diff --git a/.gitmodules b/.gitmodules
index 14670a363..585da846a 100644
--- a/.gitmodules
+++ b/.gitmodules
@@ -16,6 +16,3 @@
 [submodule "examples/ManualModel"]
 	path = examples/ManualModel
 	url = https://github.com/Open-Systems-Pharmacology/Example_ManualModel.git
-[submodule "simmodel.schema"]
-	path = simmodel.schema
-	url = https://github.com/Open-Systems-Pharmacology/OSPSuite.SimModel.Schema.git
diff --git a/SolutionInfo.cs b/SolutionInfo.cs
index 7ec89c8ed..fe8f7bc44 100644
--- a/SolutionInfo.cs
+++ b/SolutionInfo.cs
@@ -6,9 +6,6 @@
 [assembly: AssemblyProduct("MoBi")]
 [assembly: AssemblyCopyright("Copyright © 2002-2019 - Open Systems Pharmacology Community")]
 [assembly: ComVisible(false)]
-[assembly: AssemblyVersion("8.0.0")]
-[assembly: AssemblyFileVersion("8.0.0")]
-[assembly: AssemblyInformationalVersion("8.0.0")]
 
 [assembly: InternalsVisibleTo("MoBi.Tests")]
 [assembly: InternalsVisibleTo("MoBi.UI.Tests")]
diff --git a/appveyor-coverage.yml b/appveyor-coverage.yml
index 0af9529c1..be60d478b 100644
--- a/appveyor-coverage.yml
+++ b/appveyor-coverage.yml
@@ -1,9 +1,10 @@
 configuration: Debug
-image: Visual Studio 2017
+image: Visual Studio 2019
 
 environment:
+  app_version: '9.0'
   MIK_TEX_INSTALL_DIR: 'C:\MikTex\'
-  app_version: '8.0'
+  APPVEYOR_BLOCK_DOTNETCORE_TESTS_AUTORUN: true
 
 version: '$(app_version).{build}'
 
@@ -15,17 +16,14 @@ assembly_info:
 
 clone_depth: 1
 
-cache:
-  packages -> **\packages.config 
-
 install:
-- set PATH=C:\Ruby22\bin;C:\\Python34;C:\\Python34\\Scripts;%PATH%"
-- pip install codecov
-- git submodule update --init --recursive
-- ps: >-
-    (new-object net.webclient).DownloadFile('https://github.com/Open-Systems-Pharmacology/MiKTeX/releases/download/v2.9.3/MikTex.2.9.3.msi', 'C:\\MikTex.msi')
+  - set PATH=C:\Ruby22\bin;C:\\Python34;C:\\Python34\\Scripts;%PATH%"
+  - pip install codecov
+  - git submodule update --init --recursive
+  - ps: >-
+     (new-object net.webclient).DownloadFile('https://github.com/Open-Systems-Pharmacology/MiKTeX/releases/download/v2.9.3/MikTex.2.9.3.msi', 'C:\\MikTex.msi')
 
-    Start-Process msiexec.exe -ArgumentList /i, C:\MikTex.msi, /quiet, /qn, /norestart, INSTALLDIR=$env:MIK_TEX_INSTALL_DIR -Wait
+     Start-Process msiexec.exe -ArgumentList /i, C:\MikTex.msi, /quiet, /qn, /norestart, INSTALLDIR=$env:MIK_TEX_INSTALL_DIR -Wait
 
 before_build:
   - nuget sources add -name bddhelper -source https://ci.appveyor.com/nuget/ospsuite-bddhelper 
@@ -38,6 +36,7 @@ before_build:
   - nuget sources add -name simmodel -source https://ci.appveyor.com/nuget/ospsuite-simmodel
   - nuget sources add -name cvodes -source https://ci.appveyor.com/nuget/ospsuite-simmodel-solver-cvodes
   - nuget sources add -name core -source https://ci.appveyor.com/nuget/ospsuite-core
+  - nuget install opencover -OutputDirectory packages
   - nuget restore
 
 build:
diff --git a/appveyor-nightly.yml b/appveyor-nightly.yml
index d4bda3381..322eae5f3 100644
--- a/appveyor-nightly.yml
+++ b/appveyor-nightly.yml
@@ -1,23 +1,26 @@
 configuration: Debug
-image: Visual Studio 2017
+image: Visual Studio 2019
+
+# hack until donet patching works with PR
+init:
+  - cmd: if DEFINED APPVEYOR_PULL_REQUEST_NUMBER (Set build_number=1) ELSE (Set build_number=%APPVEYOR_BUILD_NUMBER%)
 
 environment:
-  app_version: '8.0'
+  app_version: '9.0'
+  APPVEYOR_BLOCK_DOTNETCORE_TESTS_AUTORUN: true
   MIK_TEX_INSTALL_DIR: 'C:\MikTex\'
 
 version: '$(app_version).{build}'
 
-assembly_info:
+dotnet_csproj:
   patch: true
-  file: SolutionInfo.*
-  assembly_version: "{version}"
-  assembly_file_version: "{version}"
-  assembly_informational_version: "{version}"
+  file: '**\*.csproj'
+  assembly_version: "$(app_version).$(build_number)"
+  file_version: "$(app_version).$(build_number)"
+  informational_version: "$(app_version).$(build_number)"
 
-clone_depth: 1
 
-cache:
-  packages -> **\packages.config 
+clone_depth: 1
 
 install:
 - set PATH=C:\Ruby25\bin;%PATH%
diff --git a/appveyor.yml b/appveyor.yml
index 048d96bea..aeb08f988 100644
--- a/appveyor.yml
+++ b/appveyor.yml
@@ -1,8 +1,13 @@
 configuration: Debug
-image: Visual Studio 2017
+image: Visual Studio 2019
+
+# hack until donet patching works with PR
+init:
+  - cmd: if DEFINED APPVEYOR_PULL_REQUEST_NUMBER (Set build_number=1) ELSE (Set build_number=%APPVEYOR_BUILD_NUMBER%)
 
 environment:
-  app_version: '8.0'
+  app_version: '9.0'
+  APPVEYOR_BLOCK_DOTNETCORE_TESTS_AUTORUN: true
 
 version: '$(app_version).{build}'
 
@@ -11,14 +16,12 @@ clone_depth: 1
 install:
   - git submodule update --init --recursive
 
-assembly_info:
+dotnet_csproj:
   patch: true
-  file: SolutionInfo.*	
-  assembly_version: "{version}"
-  assembly_file_version: "{version}"	
-
-cache:
-  packages -> **\packages.config  # preserve "packages" directory in the root of build folder but will reset it if packages.config is modified
+  file: '**\*.csproj'
+  assembly_version: "$(app_version).$(build_number)"
+  file_version: "$(app_version).$(build_number)"
+  informational_version: "$(app_version).$(build_number)"
 
 before_build:
   - nuget sources add -name bddhelper -source https://ci.appveyor.com/nuget/ospsuite-bddhelper 
diff --git a/dimensions b/dimensions
index da34d25c9..067cccc17 160000
--- a/dimensions
+++ b/dimensions
@@ -1 +1 @@
-Subproject commit da34d25c9fd0df82fd5353cd12c8d9852a65e847
+Subproject commit 067cccc17df5677782f3c292d0fa0ae4e4295ef1
diff --git a/pkparameters b/pkparameters
index 647082d99..18940312f 160000
--- a/pkparameters
+++ b/pkparameters
@@ -1 +1 @@
-Subproject commit 647082d99ba28f76eac84ce8b91330de6e39d401
+Subproject commit 18940312f97b3b2a3b690d3f83b88db7393d0260
diff --git a/rakefile.rb b/rakefile.rb
index 3e92f497c..ac1a1cc8f 100644
--- a/rakefile.rb
+++ b/rakefile.rb
@@ -9,23 +9,29 @@
 	filter << "+[MoBi.Assets]*"
 	filter << "+[MoBi.Presentation]*"
 
-	Coverage.cover(filter , "MoBi.Tests.csproj")
+	 targetProjects = [
+		"MoBi.Tests.csproj",
+		"MoBi.UI.Tests.csproj",
+	];
+
+	Coverage.cover(filter , targetProjects)
 end
 
 task :create_setup, [:product_version, :configuration, :smart_xls_package, :smart_xls_version] do |t, args|
 	update_smart_xls args
 
+	src_dir = src_dir_for(args.configuration)
+	relative_src_dir = relative_src_dir_for(args.configuration)
+
 	#Ignore files from automatic harvesting that will be installed specifically
 	harvest_ignored_files = [
-		'MoBi.exe',
-		'Standard Molecule.pkml'
+    'MoBi.exe'
 	]
 
 	#Files required for setup creation only
 	setup_files	 = [
-		'packages/**/OSPSuite.Core/**/*.xml',
-		'packages/**/OSPSuite.Presentation/**/*.{wxs,xml}',
-		'packages/**/OSPSuite.TeXReporting/**/*.*',
+		"#{relative_src_dir}/ChartLayouts/**/*.{wxs,xml}",
+		"#{relative_src_dir}/TeXTemplates/**/*.*",
 		'examples/**/*.{wxs,pkml,mbp3}',
 		'src/Data/**/*.*',
 		'src/MoBi.Assets/Resources/*.ico',
@@ -39,7 +45,7 @@
 
 	Rake::Task['setup:create'].execute(OpenStruct.new(
 		solution_dir: solution_dir,
-		src_dir: src_dir_for(args.configuration),  
+		src_dir: src_dir,  
 		setup_dir: setup_dir,  
 		product_name: product_name, 
 		product_version: args.product_version,
@@ -51,25 +57,28 @@
 end
 
 task :create_portable_setup, [:product_version, :configuration, :package_name] do |t, args|
+	src_dir = src_dir_for(args.configuration)
+	relative_src_dir = relative_src_dir_for(args.configuration)
+
+	copy_templates_files src_dir
+
 	#Files required for setup creation only and that will not be harvested automatically
 	setup_files	 = [
 		'Open Systems Pharmacology Suite License.pdf',
 		'documentation/*.pdf',
 		'dimensions/*.xml',
 		'pkparameters/*.xml',
-		'src/Data/*.xml',
+		'src/Data/**/*.*',
 		'setup/**/*.{rtf}',
 	]
 
 	setup_folders = [
+		"#{setup_temp_dir}/**/*.*",
 		'examples/**/*.{pkml,mbp3}',
-		'packages/**/OSPSuite.Presentation/**/*.{xml}',
-		'packages/**/OSPSuite.TeXReporting/**/*.{json,sty,tex}',
 	]
-
 	Rake::Task['setup:create_portable'].execute(OpenStruct.new(
 		solution_dir: solution_dir,
-		src_dir: src_dir_for(args.configuration), 
+		src_dir: src_dir, 
 		setup_dir: setup_dir,  
 		product_name: product_name, 
 		product_version: args.product_version,
@@ -85,8 +94,18 @@
 	Utils.update_go_diagram_license args.file_path, args.license
 end	
 
+def copy_templates_files(source_dir)
+	FileUtils.mkdir_p setup_temp_dir
+	FileUtils.copy_entry File.join(source_dir, 'TeXTemplates'), File.join(setup_temp_dir, 'TeXTemplates')
+	FileUtils.copy_entry File.join(source_dir, 'ChartLayouts'), File.join(setup_temp_dir, 'ChartLayouts')
+end
+
+def relative_src_dir_for(configuration)
+	File.join('src', 'MoBi', 'bin', configuration, 'net472')
+end
+
 def src_dir_for(configuration)
-	File.join(solution_dir, 'src', 'MoBi', 'bin', configuration)
+	File.join(solution_dir, relative_src_dir_for(configuration))
 end
 
 def update_smart_xls(args) 
@@ -101,27 +120,27 @@ def update_smart_xls(args)
 end
 
 task :postclean do |t, args| 
-	packages_dir =  File.join(solution_dir, 'packages')
+	packages_dir =  src_dir_for("Debug")
 
 	all_users_dir = ENV['ALLUSERSPROFILE']
-	all_users_application_dir = File.join(all_users_dir, manufacturer, product_name, '8.0')
+	all_users_application_dir = File.join(all_users_dir, manufacturer, product_name, '9.0')
 
-	copy_depdencies solution_dir,  all_users_application_dir do
+	copy_dependencies solution_dir,  all_users_application_dir do
 		copy_files 'Data', ['xml', 'mbdt']
 		copy_file 'src/Data/AllCalculationMethods.pkml'
 		copy_dimensions_xml
 		copy_pkparameters_xml
 	end
 
-	copy_depdencies solution_dir,  File.join(all_users_application_dir, 'Templates') do
+	copy_dependencies solution_dir,  File.join(all_users_application_dir, 'Templates') do
 		copy_templates_pkml
 	end
 
-	copy_depdencies packages_dir,   File.join(all_users_application_dir, 'ChartLayouts') do
-		copy_files 'OSPSuite.Presentation', 'xml'
+	copy_dependencies packages_dir,   File.join(all_users_application_dir, 'ChartLayouts') do
+		copy_files 'ChartLayouts', 'xml'
 	end
 
-	copy_depdencies packages_dir,   File.join(all_users_application_dir, 'TeXTemplates', 'StandardTemplate') do
+	copy_dependencies packages_dir,   File.join(all_users_application_dir, 'TeXTemplates', 'StandardTemplate') do
 		copy_files 'StandardTemplate', '*'
 	end
 end
@@ -146,4 +165,8 @@ def suite_name
 
 def setup_dir
 	File.join(solution_dir, 'setup')
+end
+
+def setup_temp_dir
+	File.join(setup_dir, 'temp')
 end
\ No newline at end of file
diff --git a/scripts b/scripts
index 1533da91c..8a4929193 160000
--- a/scripts
+++ b/scripts
@@ -1 +1 @@
-Subproject commit 1533da91c69e9d4fe53c49479f57f11bf458a438
+Subproject commit 8a49291933a14f17f25a6112507ce466bb2805da
diff --git a/simmodel.schema b/simmodel.schema
deleted file mode 160000
index ba10b251d..000000000
--- a/simmodel.schema
+++ /dev/null
@@ -1 +0,0 @@
-Subproject commit ba10b251d111d6370d04904da2b261acdc7279dd
diff --git a/src/Data/AllCalculationMethods.pkml b/src/Data/AllCalculationMethods.pkml
index 53689f292..894f6dcb6 100644
--- a/src/Data/AllCalculationMethods.pkml
+++ b/src/Data/AllCalculationMethods.pkml
@@ -1,8 +1,8 @@
 <?xml version="1.0" encoding="utf-8"?>
-<CoreCalculationMethodRepository version="13">
+<CoreCalculationMethodRepository version="14">
   <All>
     <CoreCalculationMethod name="Cellular partition coefficient method - Berezhkovskiy" icon="CoreCalculationMethod" bbVersion="0" category="DistributionCellular">
-      <Creation createdAt="5248306844190215328" createdBy="EZZJY" creationMode="New" origin="Other" />
+      <Creation createdAt="5248852327097877907" createdBy="Michael" creationMode="New" origin="Other" />
       <OutputFormulas>
         <KeyValue>
           <Formula id="Cellular partition coefficient method - Berezhkovskiy.PARAM_K_rbc" name="PARAM_K_rbc" formula="(f_water_rbc + f_lipids_rbc * 10^LogMA + f_proteins_rbc * KProt)*fu">
@@ -72,7 +72,7 @@
       </OutputFormulas>
       <HelpParameters>
         <KeyValue>
-          <Parameter id="7lzPetCHo0q8y_eC0H-qYA" name="logP (oil/water,pKa)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Berezhkovskiy.PARAM_LogP_ow_pKa" isDefault="1">
+          <Parameter id="cynxnEOnm0mvmzcdhEqelw" name="logP (oil/water,pKa)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Berezhkovskiy.PARAM_LogP_ow_pKa" isDefault="1">
             <Info flag="58" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -82,7 +82,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="3zjRHtQHr0-c_qNGpf56vA" name="logP (veg.oil/water)" icon="Parameter" persistable="0" isFixedValue="0" dim="Log Units" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Berezhkovskiy.PARAM_LogP_ow" isDefault="1" displayUnit="Log Units">
+          <Parameter id="kbT4EHCboUWrlGECjcW9xw" name="logP (veg.oil/water)" icon="Parameter" persistable="0" isFixedValue="0" dim="Log Units" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Berezhkovskiy.PARAM_LogP_ow" isDefault="1" displayUnit="Log Units">
             <Info flag="58" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -92,7 +92,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="nmeNbLPWy0qTyUkxrysgHA" name="LogPow_pKa_DiproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Berezhkovskiy.PARAM_LogPow_pKa_DiproticAcid" isDefault="1">
+          <Parameter id="z5C7-jRqRkW6X45mfB-Cxw" name="LogPow_pKa_DiproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Berezhkovskiy.PARAM_LogPow_pKa_DiproticAcid" isDefault="1">
             <Info flag="52" seq="1" ref="0" bb="2" group="16" />
           </Parameter>
           <DescriptorCriteria>
@@ -102,7 +102,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="OAY2d_f2JkCttFHAm5PZmQ" name="LogPow_pKa_DiproticBase" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Berezhkovskiy.PARAM_LogPow_pKa_DiproticBase" isDefault="1">
+          <Parameter id="FY8JKH5CQ0ez4ktHzXGOTg" name="LogPow_pKa_DiproticBase" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Berezhkovskiy.PARAM_LogPow_pKa_DiproticBase" isDefault="1">
             <Info flag="52" seq="1" ref="0" bb="2" group="16" />
           </Parameter>
           <DescriptorCriteria>
@@ -112,7 +112,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="P65kkHa580GVZf52RQWntw" name="LogPow_pKa_DiproticBaseMonoproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Berezhkovskiy.PARAM_LogPow_pKa_DiproticBaseMonoproticAcid" isDefault="1">
+          <Parameter id="tZZ1cHMFxEix0zqDQCHPsw" name="LogPow_pKa_DiproticBaseMonoproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Berezhkovskiy.PARAM_LogPow_pKa_DiproticBaseMonoproticAcid" isDefault="1">
             <Info flag="52" seq="1" ref="0" bb="2" group="16" />
           </Parameter>
           <DescriptorCriteria>
@@ -122,7 +122,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="m_7Xc6t3S0Wo27GUy81moA" name="LogPow_pKa_MonoproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Berezhkovskiy.PARAM_LogPow_pKa_MonoproticAcid" isDefault="1">
+          <Parameter id="s0rtVsRSQk2SkG2qJhhqPg" name="LogPow_pKa_MonoproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Berezhkovskiy.PARAM_LogPow_pKa_MonoproticAcid" isDefault="1">
             <Info flag="52" seq="1" ref="0" bb="2" group="16" />
           </Parameter>
           <DescriptorCriteria>
@@ -132,7 +132,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="xzKdJetRmkmm1BGanjwNaQ" name="LogPow_pKa_MonoproticBase" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Berezhkovskiy.PARAM_LogPow_pKa_MonoproticBase" isDefault="1">
+          <Parameter id="ZlSRelHp6EmCaw9DFDX_lg" name="LogPow_pKa_MonoproticBase" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Berezhkovskiy.PARAM_LogPow_pKa_MonoproticBase" isDefault="1">
             <Info flag="52" seq="1" ref="0" bb="2" group="16" />
           </Parameter>
           <DescriptorCriteria>
@@ -142,7 +142,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="3qO6r9632U-XX77zGbelnA" name="LogPow_pKa_MonoproticBaseDiproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Berezhkovskiy.PARAM_LogPow_pKa_MonoproticBaseDiproticAcid" isDefault="1">
+          <Parameter id="U9OUHd2ZE06UVUshZ2KlnQ" name="LogPow_pKa_MonoproticBaseDiproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Berezhkovskiy.PARAM_LogPow_pKa_MonoproticBaseDiproticAcid" isDefault="1">
             <Info flag="52" seq="1" ref="0" bb="2" group="16" />
           </Parameter>
           <DescriptorCriteria>
@@ -152,7 +152,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="4cZ0ZwC41UGP9jtXS-z8tw" name="LogPow_pKa_MonoproticBaseMonoproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Berezhkovskiy.PARAM_LogPow_pKa_MonoproticBaseMonoproticAcid" isDefault="1">
+          <Parameter id="Lx2vu-sTeUSICd5HKtEZTA" name="LogPow_pKa_MonoproticBaseMonoproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Berezhkovskiy.PARAM_LogPow_pKa_MonoproticBaseMonoproticAcid" isDefault="1">
             <Info flag="52" seq="1" ref="0" bb="2" group="16" />
           </Parameter>
           <DescriptorCriteria>
@@ -162,7 +162,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="rCWjgnrs2kqe5mvcb7rVeg" name="LogPow_pKa_Neutral" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0">
+          <Parameter id="Ri7dL5crHkOFNGgjoxLt1g" name="LogPow_pKa_Neutral" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0">
             <Info flag="52" seq="1" ref="0" bb="2" group="16" />
           </Parameter>
           <DescriptorCriteria>
@@ -172,7 +172,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="UUCndzR7IEaKCXRofRQJZQ" name="LogPow_pKa_TriproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Berezhkovskiy.PARAM_LogPow_pKa_TriproticAcid" isDefault="1">
+          <Parameter id="AVit9xBkOEOua6tdBT9YTg" name="LogPow_pKa_TriproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Berezhkovskiy.PARAM_LogPow_pKa_TriproticAcid" isDefault="1">
             <Info flag="52" seq="1" ref="0" bb="2" group="16" />
           </Parameter>
           <DescriptorCriteria>
@@ -182,7 +182,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="hW_s3BjT60iziUcIHw__NA" name="LogPow_pKa_TriproticBase" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Berezhkovskiy.PARAM_LogPow_pKa_TriproticBase" isDefault="1">
+          <Parameter id="9iy6OzN1WkOEST4gkOowoQ" name="LogPow_pKa_TriproticBase" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Berezhkovskiy.PARAM_LogPow_pKa_TriproticBase" isDefault="1">
             <Info flag="52" seq="1" ref="0" bb="2" group="16" />
           </Parameter>
           <DescriptorCriteria>
@@ -192,7 +192,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="YXUk7TW16kmENygPkMq-Xg" name="Fraction unbound (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Berezhkovskiy.PARAM_fu_tissue_Berezhkovskiy" isDefault="1">
+          <Parameter id="StVGYumwZUGEcuXulbCJRA" name="Fraction unbound (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Berezhkovskiy.PARAM_fu_tissue_Berezhkovskiy" isDefault="1">
             <Info flag="58" seq="1" ref="0" bb="2" group="22" />
           </Parameter>
           <DescriptorCriteria>
@@ -397,7 +397,7 @@
       </FormulaCache>
     </CoreCalculationMethod>
     <CoreCalculationMethod name="Cellular partition coefficient method - PK-Sim Standard" icon="CoreCalculationMethod" bbVersion="0" category="DistributionCellular">
-      <Creation createdAt="5248306844190365337" createdBy="EZZJY" creationMode="New" origin="Other" />
+      <Creation createdAt="5248852327097997401" createdBy="Michael" creationMode="New" origin="Other" />
       <OutputFormulas>
         <KeyValue>
           <Formula id="Cellular partition coefficient method - PK-Sim Standard.PARAM_K_rbc" name="PARAM_K_rbc" formula="(f_water_rbc + f_lipids_rbc * 10^LogMA + f_proteins_rbc * KProt)*fu">
@@ -465,7 +465,7 @@
       </FormulaCache>
     </CoreCalculationMethod>
     <CoreCalculationMethod name="Cellular partition coefficient method - Poulin and Theil" icon="CoreCalculationMethod" bbVersion="0" category="DistributionCellular">
-      <Creation createdAt="5248306844190365337" createdBy="EZZJY" creationMode="New" origin="Other" />
+      <Creation createdAt="5248852327097997401" createdBy="Michael" creationMode="New" origin="Other" />
       <OutputFormulas>
         <KeyValue>
           <Formula id="Cellular partition coefficient method - Poulin and Theil.PARAM_K_rbc" name="PARAM_K_rbc" formula="(f_water_rbc + f_lipids_rbc * 10^LogMA + f_proteins_rbc * KProt)*fu">
@@ -535,7 +535,7 @@
       </OutputFormulas>
       <HelpParameters>
         <KeyValue>
-          <Parameter id="hf_yE96tmEWDK-Egb-N8og" name="logP (oil/water,pKa)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Poulin and Theil.PARAM_LogP_ow_pKa" isDefault="1">
+          <Parameter id="EjFfj4esKESPvFAb9KLnbg" name="logP (oil/water,pKa)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Poulin and Theil.PARAM_LogP_ow_pKa" isDefault="1">
             <Info flag="58" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -545,7 +545,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="JsM1H_Rz40KUDywvaF_Cug" name="logP (veg.oil/water)" icon="Parameter" persistable="0" isFixedValue="0" dim="Log Units" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Poulin and Theil.PARAM_LogP_ow" isDefault="1" displayUnit="Log Units">
+          <Parameter id="xZX51aK6YEWUVpaeBMGyEQ" name="logP (veg.oil/water)" icon="Parameter" persistable="0" isFixedValue="0" dim="Log Units" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Poulin and Theil.PARAM_LogP_ow" isDefault="1" displayUnit="Log Units">
             <Info flag="58" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -555,7 +555,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="He-PFsQSUEmM4wq44R2IvA" name="LogPow_pKa_DiproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Poulin and Theil.PARAM_LogPow_pKa_DiproticAcid" isDefault="1">
+          <Parameter id="zMcf3zhU6EOkHzAfbNGyjA" name="LogPow_pKa_DiproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Poulin and Theil.PARAM_LogPow_pKa_DiproticAcid" isDefault="1">
             <Info flag="52" seq="1" ref="0" bb="2" group="16" />
           </Parameter>
           <DescriptorCriteria>
@@ -565,7 +565,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="Pvb_RAdXhUORQ511qMsMsg" name="LogPow_pKa_DiproticBase" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Poulin and Theil.PARAM_LogPow_pKa_DiproticBase" isDefault="1">
+          <Parameter id="HH5GCz4XLEShtLl7fbhpfg" name="LogPow_pKa_DiproticBase" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Poulin and Theil.PARAM_LogPow_pKa_DiproticBase" isDefault="1">
             <Info flag="52" seq="1" ref="0" bb="2" group="16" />
           </Parameter>
           <DescriptorCriteria>
@@ -575,7 +575,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="REMli4Mz9EKIzHRDoIuz7A" name="LogPow_pKa_DiproticBaseMonoproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Poulin and Theil.PARAM_LogPow_pKa_DiproticBaseMonoproticAcid" isDefault="1">
+          <Parameter id="uygB250hKkyhLMBFvB9nYw" name="LogPow_pKa_DiproticBaseMonoproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Poulin and Theil.PARAM_LogPow_pKa_DiproticBaseMonoproticAcid" isDefault="1">
             <Info flag="52" seq="1" ref="0" bb="2" group="16" />
           </Parameter>
           <DescriptorCriteria>
@@ -585,7 +585,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="w9U4uZmcW0CkC8Lyxw5JNQ" name="LogPow_pKa_MonoproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Poulin and Theil.PARAM_LogPow_pKa_MonoproticAcid" isDefault="1">
+          <Parameter id="MyDTLPbEnkySQAJp92RaRg" name="LogPow_pKa_MonoproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Poulin and Theil.PARAM_LogPow_pKa_MonoproticAcid" isDefault="1">
             <Info flag="52" seq="1" ref="0" bb="2" group="16" />
           </Parameter>
           <DescriptorCriteria>
@@ -595,7 +595,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="1eOrE6bsEE-VNBRmAHSCbQ" name="LogPow_pKa_MonoproticBase" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Poulin and Theil.PARAM_LogPow_pKa_MonoproticBase" isDefault="1">
+          <Parameter id="9WOiEpdvM066z4MDBj-RGA" name="LogPow_pKa_MonoproticBase" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Poulin and Theil.PARAM_LogPow_pKa_MonoproticBase" isDefault="1">
             <Info flag="52" seq="1" ref="0" bb="2" group="16" />
           </Parameter>
           <DescriptorCriteria>
@@ -605,7 +605,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="jF5fnkv-fkacK8T3H5Y0Ig" name="LogPow_pKa_MonoproticBaseDiproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Poulin and Theil.PARAM_LogPow_pKa_MonoproticBaseDiproticAcid" isDefault="1">
+          <Parameter id="GGSqpS8sf0mS3HtE6EO5TQ" name="LogPow_pKa_MonoproticBaseDiproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Poulin and Theil.PARAM_LogPow_pKa_MonoproticBaseDiproticAcid" isDefault="1">
             <Info flag="52" seq="1" ref="0" bb="2" group="16" />
           </Parameter>
           <DescriptorCriteria>
@@ -615,7 +615,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="XTJncIzQ4Emif1uIYOEAzQ" name="LogPow_pKa_MonoproticBaseMonoproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Poulin and Theil.PARAM_LogPow_pKa_MonoproticBaseMonoproticAcid" isDefault="1">
+          <Parameter id="bYgOLblvqEGuV1brwISwcw" name="LogPow_pKa_MonoproticBaseMonoproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Poulin and Theil.PARAM_LogPow_pKa_MonoproticBaseMonoproticAcid" isDefault="1">
             <Info flag="52" seq="1" ref="0" bb="2" group="16" />
           </Parameter>
           <DescriptorCriteria>
@@ -625,7 +625,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="o4giDKxNckeau0eKkoLSlA" name="LogPow_pKa_Neutral" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0">
+          <Parameter id="rw9WvgWrlkyJHvBIQ0ScQQ" name="LogPow_pKa_Neutral" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0">
             <Info flag="52" seq="1" ref="0" bb="2" group="16" />
           </Parameter>
           <DescriptorCriteria>
@@ -635,7 +635,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="G_wyAFtX9ECDGGEtYUs5jg" name="LogPow_pKa_TriproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Poulin and Theil.PARAM_LogPow_pKa_TriproticAcid" isDefault="1">
+          <Parameter id="DQvJxN_YMkWmDWHioSeSkw" name="LogPow_pKa_TriproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Poulin and Theil.PARAM_LogPow_pKa_TriproticAcid" isDefault="1">
             <Info flag="52" seq="1" ref="0" bb="2" group="16" />
           </Parameter>
           <DescriptorCriteria>
@@ -645,7 +645,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="cS2_4EiclEuzUtVE1ED1oA" name="LogPow_pKa_TriproticBase" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Poulin and Theil.PARAM_LogPow_pKa_TriproticBase" isDefault="1">
+          <Parameter id="XaWFCt2o8E68Vt-_oXSlxw" name="LogPow_pKa_TriproticBase" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Poulin and Theil.PARAM_LogPow_pKa_TriproticBase" isDefault="1">
             <Info flag="52" seq="1" ref="0" bb="2" group="16" />
           </Parameter>
           <DescriptorCriteria>
@@ -655,7 +655,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="OwBk-f7XZ06-rWFhZEpNNw" name="Fraction unbound (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Poulin and Theil.PARAM_fu_tissue_Poulin_and_Theil" isDefault="1">
+          <Parameter id="BS32xGx_NE--bMhsGFmDBQ" name="Fraction unbound (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Poulin and Theil.PARAM_fu_tissue_Poulin_and_Theil" isDefault="1">
             <Info flag="58" seq="1" ref="0" bb="2" group="22" />
           </Parameter>
           <DescriptorCriteria>
@@ -860,7 +860,7 @@
       </FormulaCache>
     </CoreCalculationMethod>
     <CoreCalculationMethod name="Cellular partition coefficient method - Rodgers and Rowland" icon="CoreCalculationMethod" bbVersion="0" category="DistributionCellular">
-      <Creation createdAt="5248306844190415340" createdBy="EZZJY" creationMode="New" origin="Other" />
+      <Creation createdAt="5248852327098007344" createdBy="Michael" creationMode="New" origin="Other" />
       <OutputFormulas>
         <KeyValue>
           <Formula id="Cellular partition coefficient method - Rodgers and Rowland.PARAM_K_rbc" name="PARAM_K_rbc" formula="K_pu_bc*fu">
@@ -914,9 +914,9 @@
               <Path path="7" as="8" />
               <Path path="9" as="10" />
               <Path path="11" as="12" />
-              <Path path="34" as="35" dim="15" />
               <Path path="16" as="17" />
               <Path path="18" as="19" />
+              <Path path="34" as="35" dim="15" />
               <Path path="20" as="21" />
               <Path path="22" as="23" />
               <Path path="24" as="25" />
@@ -938,7 +938,7 @@
       </OutputFormulas>
       <HelpParameters>
         <KeyValue>
-          <Parameter id="NKYtgfvVJUqyObu4lzBp6w" name="Ka (acidic phospholipids)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Rodgers and Rowland.PARAM_Ka_AP" isDefault="1">
+          <Parameter id="aWplepBpyESIn9jr4nZW_w" name="Ka (acidic phospholipids)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Rodgers and Rowland.PARAM_Ka_AP" isDefault="1">
             <Info flag="58" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -948,7 +948,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="9aGj3NoLR0S29Ov6yqCdyw" name="Ka (proteins)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Rodgers and Rowland.PARAM_Ka_PR" isDefault="1">
+          <Parameter id="5-4y6ws-nUWtTFl-fHzEBg" name="Ka (proteins)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Rodgers and Rowland.PARAM_Ka_PR" isDefault="1">
             <Info flag="58" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -958,7 +958,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="WQmcQlpuXkeaH1hmbrz8Iw" name="logP (veg.oil/water)" icon="Parameter" persistable="0" isFixedValue="0" dim="Log Units" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Rodgers and Rowland.PARAM_LogP_ow" isDefault="1" displayUnit="Log Units">
+          <Parameter id="JLJvEt0NAEOEhEHyLsnn9w" name="logP (veg.oil/water)" icon="Parameter" persistable="0" isFixedValue="0" dim="Log Units" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Rodgers and Rowland.PARAM_LogP_ow" isDefault="1" displayUnit="Log Units">
             <Info flag="58" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -968,7 +968,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="XQhFUXHvSkqOuzUM3s80tA" name="Partition coefficient (blood cells/plasma unbound)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Rodgers and Rowland.PARAM_Kpu_bc" isDefault="1">
+          <Parameter id="5LTaA-HEJkWhg6VR64libQ" name="Partition coefficient (blood cells/plasma unbound)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Rodgers and Rowland.PARAM_Kpu_bc" isDefault="1">
             <Info flag="58" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -978,7 +978,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="U0G8DPlk-UqfY_AJB14gMA" name="X" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Rodgers and Rowland.PARAM_X" isDefault="1">
+          <Parameter id="TOfxN42AAEamLR9HpoYwUw" name="X" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Rodgers and Rowland.PARAM_X" isDefault="1">
             <Info flag="52" seq="1" ref="0" bb="2" group="16" />
           </Parameter>
           <DescriptorCriteria>
@@ -988,7 +988,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="dZMKtbHzCkSRbxG3goKRNQ" name="X_DiproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Rodgers and Rowland.PARAM_X_DiproticAcid" isDefault="1">
+          <Parameter id="jtkRGiar-0uTKds7SHO7hw" name="X_DiproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Rodgers and Rowland.PARAM_X_DiproticAcid" isDefault="1">
             <Info flag="52" seq="1" ref="0" bb="2" group="16" />
           </Parameter>
           <DescriptorCriteria>
@@ -998,7 +998,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="MNa3uznDJ02VVyZCdMj_BQ" name="X_DiproticBase" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Rodgers and Rowland.PARAM_X_DiproticBase" isDefault="1">
+          <Parameter id="c3GxyY8siEmkh0nX5NIruQ" name="X_DiproticBase" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Rodgers and Rowland.PARAM_X_DiproticBase" isDefault="1">
             <Info flag="52" seq="1" ref="0" bb="2" group="16" />
           </Parameter>
           <DescriptorCriteria>
@@ -1008,7 +1008,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="T4wkVAtos0GCNWLSkVVKmw" name="X_DiproticBaseMonoproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Rodgers and Rowland.PARAM_X_DiproticBaseMonoproticAcid" isDefault="1">
+          <Parameter id="oLGpl_gpM0-lKScDrnkzwg" name="X_DiproticBaseMonoproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Rodgers and Rowland.PARAM_X_DiproticBaseMonoproticAcid" isDefault="1">
             <Info flag="52" seq="1" ref="0" bb="2" group="16" />
           </Parameter>
           <DescriptorCriteria>
@@ -1018,7 +1018,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="ViifdHvO1EqtUXRfVE31KQ" name="X_MonoproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Rodgers and Rowland.PARAM_X_MonoproticAcid" isDefault="1">
+          <Parameter id="wybx-rPmUU-JviQQwv8Dng" name="X_MonoproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Rodgers and Rowland.PARAM_X_MonoproticAcid" isDefault="1">
             <Info flag="52" seq="1" ref="0" bb="2" group="16" />
           </Parameter>
           <DescriptorCriteria>
@@ -1028,7 +1028,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="madf5acRs0qv5DXmlwQeEw" name="X_MonoproticBase" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Rodgers and Rowland.PARAM_X_MonoproticBase" isDefault="1">
+          <Parameter id="-lScqAmyfkqk3IQCr6vukg" name="X_MonoproticBase" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Rodgers and Rowland.PARAM_X_MonoproticBase" isDefault="1">
             <Info flag="52" seq="1" ref="0" bb="2" group="16" />
           </Parameter>
           <DescriptorCriteria>
@@ -1038,7 +1038,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="rwRU2PAHtEWIx-ImCkRqJQ" name="X_MonoproticBaseDiproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Rodgers and Rowland.PARAM_X_MonoproticBaseDiproticAcid" isDefault="1">
+          <Parameter id="DWTY9MIWx0i0lSj81w03Wg" name="X_MonoproticBaseDiproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Rodgers and Rowland.PARAM_X_MonoproticBaseDiproticAcid" isDefault="1">
             <Info flag="52" seq="1" ref="0" bb="2" group="16" />
           </Parameter>
           <DescriptorCriteria>
@@ -1048,7 +1048,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="c6Mly8nyXEu2mA7502qpcw" name="X_MonoproticBaseMonoproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Rodgers and Rowland.PARAM_X_MonoproticBaseMonoproticAcid" isDefault="1">
+          <Parameter id="IYGLnJHi_kGX-yvvk14fKg" name="X_MonoproticBaseMonoproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Rodgers and Rowland.PARAM_X_MonoproticBaseMonoproticAcid" isDefault="1">
             <Info flag="52" seq="1" ref="0" bb="2" group="16" />
           </Parameter>
           <DescriptorCriteria>
@@ -1058,7 +1058,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="MjVQXfxhfEWa7aw8-JByow" name="X_Neutral" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0">
+          <Parameter id="PSGnMGpImUqFl1BEdX8UUA" name="X_Neutral" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0">
             <Info flag="52" seq="1" ref="0" bb="2" group="16" />
           </Parameter>
           <DescriptorCriteria>
@@ -1068,7 +1068,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="H2hVnaDAWUi35j75nh2TGw" name="X_TriproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Rodgers and Rowland.PARAM_X_TriproticAcid" isDefault="1">
+          <Parameter id="S1F_UbJpRU2YIAv4DxDPLA" name="X_TriproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Rodgers and Rowland.PARAM_X_TriproticAcid" isDefault="1">
             <Info flag="52" seq="1" ref="0" bb="2" group="16" />
           </Parameter>
           <DescriptorCriteria>
@@ -1078,7 +1078,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="p1GCkKWSckOKBczAPzXu1g" name="X_TriproticBase" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Rodgers and Rowland.PARAM_X_TriproticBase" isDefault="1">
+          <Parameter id="NmsNoINEP0qOwOJu4kCYOA" name="X_TriproticBase" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Rodgers and Rowland.PARAM_X_TriproticBase" isDefault="1">
             <Info flag="52" seq="1" ref="0" bb="2" group="16" />
           </Parameter>
           <DescriptorCriteria>
@@ -1088,7 +1088,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="Yx1P2sPkg0Kx2QyTzBBnGQ" name="Y" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Rodgers and Rowland.PARAM_Y" isDefault="1">
+          <Parameter id="szvi1TqoQUqF7FWEcGxisg" name="Y" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Rodgers and Rowland.PARAM_Y" isDefault="1">
             <Info flag="52" seq="1" ref="0" bb="2" group="16" />
           </Parameter>
           <DescriptorCriteria>
@@ -1098,7 +1098,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="otvEaev_G0SuZpQ0KuXNLw" name="Y_DiproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Rodgers and Rowland.PARAM_Y_DiproticAcid" isDefault="1">
+          <Parameter id="fQPWzILH2UOK97qCqNb2Gg" name="Y_DiproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Rodgers and Rowland.PARAM_Y_DiproticAcid" isDefault="1">
             <Info flag="52" seq="1" ref="0" bb="2" group="16" />
           </Parameter>
           <DescriptorCriteria>
@@ -1108,7 +1108,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="9oYUPXGHwU6W4TTnURHYLw" name="Y_DiproticBase" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Rodgers and Rowland.PARAM_Y_DiproticBase" isDefault="1">
+          <Parameter id="YqaC1UlrUkmiALY9pUvJZw" name="Y_DiproticBase" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Rodgers and Rowland.PARAM_Y_DiproticBase" isDefault="1">
             <Info flag="52" seq="1" ref="0" bb="2" group="16" />
           </Parameter>
           <DescriptorCriteria>
@@ -1118,7 +1118,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="ghyx_bdpMkWA0yxTwc0x0w" name="Y_DiproticBaseMonoproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Rodgers and Rowland.PARAM_Y_DiproticBaseMonoproticAcid" isDefault="1">
+          <Parameter id="EkUnpd6TRUSE6lmwur0emQ" name="Y_DiproticBaseMonoproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Rodgers and Rowland.PARAM_Y_DiproticBaseMonoproticAcid" isDefault="1">
             <Info flag="52" seq="1" ref="0" bb="2" group="16" />
           </Parameter>
           <DescriptorCriteria>
@@ -1128,7 +1128,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="t9GGvvPeukS68m0jfYFj3Q" name="Y_MonoproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Rodgers and Rowland.PARAM_Y_MonoproticAcid" isDefault="1">
+          <Parameter id="3hLi-EkaKEKfw9T59bRkjg" name="Y_MonoproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Rodgers and Rowland.PARAM_Y_MonoproticAcid" isDefault="1">
             <Info flag="52" seq="1" ref="0" bb="2" group="16" />
           </Parameter>
           <DescriptorCriteria>
@@ -1138,7 +1138,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="av85ab_MFUqnUoUa2rpanQ" name="Y_MonoproticBase" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Rodgers and Rowland.PARAM_Y_MonoproticBase" isDefault="1">
+          <Parameter id="rGt8RAOql0isjClQsiNfww" name="Y_MonoproticBase" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Rodgers and Rowland.PARAM_Y_MonoproticBase" isDefault="1">
             <Info flag="52" seq="1" ref="0" bb="2" group="16" />
           </Parameter>
           <DescriptorCriteria>
@@ -1148,7 +1148,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="eJWDtDpf_U2g6Prxgr9Y-g" name="Y_MonoproticBaseDiproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Rodgers and Rowland.PARAM_Y_MonoproticBaseDiproticAcid" isDefault="1">
+          <Parameter id="8-g3sAh5MUaUfMkoz0CpWw" name="Y_MonoproticBaseDiproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Rodgers and Rowland.PARAM_Y_MonoproticBaseDiproticAcid" isDefault="1">
             <Info flag="52" seq="1" ref="0" bb="2" group="16" />
           </Parameter>
           <DescriptorCriteria>
@@ -1158,7 +1158,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="l_sCkUcOs0KbZwON7lHQiA" name="Y_MonoproticBaseMonoproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Rodgers and Rowland.PARAM_Y_MonoproticBaseMonoproticAcid" isDefault="1">
+          <Parameter id="jnQx88TsbUaOhIR-Ve7tpw" name="Y_MonoproticBaseMonoproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Rodgers and Rowland.PARAM_Y_MonoproticBaseMonoproticAcid" isDefault="1">
             <Info flag="52" seq="1" ref="0" bb="2" group="16" />
           </Parameter>
           <DescriptorCriteria>
@@ -1168,7 +1168,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="0eS616UWI0a10b1-TuQS8w" name="Y_Neutral" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0">
+          <Parameter id="4xRYTl1d6kOLqXQeRLY9zw" name="Y_Neutral" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0">
             <Info flag="52" seq="1" ref="0" bb="2" group="16" />
           </Parameter>
           <DescriptorCriteria>
@@ -1178,7 +1178,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="nomDlNrT9E62ntgDmI-epQ" name="Y_TriproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Rodgers and Rowland.PARAM_Y_TriproticAcid" isDefault="1">
+          <Parameter id="fINjJ-YFXEuugzRFCUBTWQ" name="Y_TriproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Rodgers and Rowland.PARAM_Y_TriproticAcid" isDefault="1">
             <Info flag="52" seq="1" ref="0" bb="2" group="16" />
           </Parameter>
           <DescriptorCriteria>
@@ -1188,7 +1188,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="CP5StPXxFk2rhgqsiiaIWg" name="Y_TriproticBase" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Rodgers and Rowland.PARAM_Y_TriproticBase" isDefault="1">
+          <Parameter id="ZmAZYv7oIkW0zktk2LxW9w" name="Y_TriproticBase" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Rodgers and Rowland.PARAM_Y_TriproticBase" isDefault="1">
             <Info flag="52" seq="1" ref="0" bb="2" group="16" />
           </Parameter>
           <DescriptorCriteria>
@@ -1198,7 +1198,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="LrFX5Pyvm0ufn1H4vvH4YA" name="Z" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Rodgers and Rowland.PARAM_Z" isDefault="1">
+          <Parameter id="r_eOzTY-mkChd70yvhTL6Q" name="Z" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Rodgers and Rowland.PARAM_Z" isDefault="1">
             <Info flag="52" seq="1" ref="0" bb="2" group="16" />
           </Parameter>
           <DescriptorCriteria>
@@ -1208,7 +1208,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="S2MROkFqu0iKSfCzTJU5wQ" name="Z_DiproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Rodgers and Rowland.PARAM_Z_DiproticAcid" isDefault="1">
+          <Parameter id="Utyn_ijjhEeCDcYxXj2Rzw" name="Z_DiproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Rodgers and Rowland.PARAM_Z_DiproticAcid" isDefault="1">
             <Info flag="52" seq="1" ref="0" bb="2" group="16" />
           </Parameter>
           <DescriptorCriteria>
@@ -1218,7 +1218,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="6bdxEk0uF0ia8P2TOJGWJw" name="Z_DiproticBase" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Rodgers and Rowland.PARAM_Z_DiproticBase" isDefault="1">
+          <Parameter id="cM9vQgqjHkOQH0LDMKVhfA" name="Z_DiproticBase" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Rodgers and Rowland.PARAM_Z_DiproticBase" isDefault="1">
             <Info flag="52" seq="1" ref="0" bb="2" group="16" />
           </Parameter>
           <DescriptorCriteria>
@@ -1228,7 +1228,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="e42_rIl9F0-2270RQ__mgw" name="Z_DiproticBaseMonoproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Rodgers and Rowland.PARAM_Z_DiproticBaseMonoproticAcid" isDefault="1">
+          <Parameter id="LVL8qkqC4EuLBhdYxtioSg" name="Z_DiproticBaseMonoproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Rodgers and Rowland.PARAM_Z_DiproticBaseMonoproticAcid" isDefault="1">
             <Info flag="52" seq="1" ref="0" bb="2" group="16" />
           </Parameter>
           <DescriptorCriteria>
@@ -1238,7 +1238,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="UXBupmPz1kWw421Q4Iv65w" name="Z_MonoproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Rodgers and Rowland.PARAM_Z_MonoproticAcid" isDefault="1">
+          <Parameter id="f0EwTTcZn0irWztvLT3GOQ" name="Z_MonoproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Rodgers and Rowland.PARAM_Z_MonoproticAcid" isDefault="1">
             <Info flag="52" seq="1" ref="0" bb="2" group="16" />
           </Parameter>
           <DescriptorCriteria>
@@ -1248,7 +1248,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="N7SWUTQnAkSzk7NLf4AiGw" name="Z_MonoproticBase" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Rodgers and Rowland.PARAM_Z_MonoproticBase" isDefault="1">
+          <Parameter id="u79wDpOFkEyA2pr1zoM6FQ" name="Z_MonoproticBase" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Rodgers and Rowland.PARAM_Z_MonoproticBase" isDefault="1">
             <Info flag="52" seq="1" ref="0" bb="2" group="16" />
           </Parameter>
           <DescriptorCriteria>
@@ -1258,7 +1258,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="L89IaqUAKk-wafY-52LKHw" name="Z_MonoproticBaseDiproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Rodgers and Rowland.PARAM_Z_MonoproticBaseDiproticAcid" isDefault="1">
+          <Parameter id="DpDXO7beO0yy6tY5RiDP2g" name="Z_MonoproticBaseDiproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Rodgers and Rowland.PARAM_Z_MonoproticBaseDiproticAcid" isDefault="1">
             <Info flag="52" seq="1" ref="0" bb="2" group="16" />
           </Parameter>
           <DescriptorCriteria>
@@ -1268,7 +1268,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="7-4YyNHJh0KhjZqMdzIM7Q" name="Z_MonoproticBaseMonoproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Rodgers and Rowland.PARAM_Z_MonoproticBaseMonoproticAcid" isDefault="1">
+          <Parameter id="YXbqE3pIVE-axkb-YjAl5g" name="Z_MonoproticBaseMonoproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Rodgers and Rowland.PARAM_Z_MonoproticBaseMonoproticAcid" isDefault="1">
             <Info flag="52" seq="1" ref="0" bb="2" group="16" />
           </Parameter>
           <DescriptorCriteria>
@@ -1278,7 +1278,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="sBto2zWl50qphGKdIE_VLg" name="Z_Neutral" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Rodgers and Rowland.PARAM_Z_Neutral" isDefault="1">
+          <Parameter id="OmsyGvCpqUywKseSNSz4Sw" name="Z_Neutral" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Rodgers and Rowland.PARAM_Z_Neutral" isDefault="1">
             <Info flag="52" seq="1" ref="0" bb="2" group="16" />
           </Parameter>
           <DescriptorCriteria>
@@ -1288,7 +1288,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="uTy6Vp4gm0iwjkkiqkoEkA" name="Z_TriproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Rodgers and Rowland.PARAM_Z_TriproticAcid" isDefault="1">
+          <Parameter id="ld-ddBurzkGKrga8ikV6QA" name="Z_TriproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Rodgers and Rowland.PARAM_Z_TriproticAcid" isDefault="1">
             <Info flag="52" seq="1" ref="0" bb="2" group="16" />
           </Parameter>
           <DescriptorCriteria>
@@ -1298,7 +1298,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="mvbEgN14NEmLOwawT643jA" name="Z_TriproticBase" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Rodgers and Rowland.PARAM_Z_TriproticBase" isDefault="1">
+          <Parameter id="ZBcfs-guSUuJIhLrQRB0Dg" name="Z_TriproticBase" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Rodgers and Rowland.PARAM_Z_TriproticBase" isDefault="1">
             <Info flag="52" seq="1" ref="0" bb="2" group="16" />
           </Parameter>
           <DescriptorCriteria>
@@ -1763,7 +1763,7 @@
       </FormulaCache>
     </CoreCalculationMethod>
     <CoreCalculationMethod name="Cellular partition coefficient method - Schmitt" icon="CoreCalculationMethod" bbVersion="0" category="DistributionCellular">
-      <Creation createdAt="5248306844190445341" createdBy="EZZJY" creationMode="New" origin="Other" />
+      <Creation createdAt="5248852327098017345" createdBy="Michael" creationMode="New" origin="Other" />
       <OutputFormulas>
         <KeyValue>
           <Formula id="Cellular partition coefficient method - Schmitt.PARAM_K_rbc" name="PARAM_K_rbc" formula="(f_w + K_n_L * f_nl + K_n_PL * f_np + K_a_PL * AP_BC + KProt * f_proteins) * fu">
@@ -1817,7 +1817,7 @@
       </OutputFormulas>
       <HelpParameters>
         <KeyValue>
-          <Parameter id="IbW2cpR9o0yNX-YsAlFjGw" name="K_a_PL_pH_Factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Schmitt.PARAM_K_a_PL_pH_Factor_BC" isDefault="1">
+          <Parameter id="q_553qudQk-VprnStBdKGw" name="K_a_PL_pH_Factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Schmitt.PARAM_K_a_PL_pH_Factor_BC" isDefault="1">
             <Info flag="52" seq="1" ref="0" bb="2" group="68" />
           </Parameter>
           <DescriptorCriteria>
@@ -1827,7 +1827,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="R0n9RrMEtUq3wzDiKe2M6Q" name="logD at pH (blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Log Units" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Schmitt.PARAM_LogD_rbc" isDefault="1" displayUnit="Log Units">
+          <Parameter id="ibrjtnZcV0uV07THx1cbFw" name="logD at pH (blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Log Units" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Schmitt.PARAM_LogD_rbc" isDefault="1" displayUnit="Log Units">
             <Info flag="58" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -1837,7 +1837,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="-nGgZzcZk06SonMaZiUTrg" name="logD factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Schmitt.PARAM_logD_Factor_RBC" isDefault="1">
+          <Parameter id="2H_8SIv5X0mAVX81ZmAmPg" name="logD factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Schmitt.PARAM_logD_Factor_RBC" isDefault="1">
             <Info flag="58" seq="1" ref="0" bb="2" group="73" />
           </Parameter>
           <DescriptorCriteria>
@@ -1847,7 +1847,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="xSB25miwhU6BtaMZdLk6Og" name="Partition coefficient (acidic phospholipids/blood cells water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Schmitt.PARAM_K_a_PL_rbc" isDefault="1">
+          <Parameter id="90Sm7bt1MUKqsB2A-AbpFQ" name="Partition coefficient (acidic phospholipids/blood cells water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Schmitt.PARAM_K_a_PL_rbc" isDefault="1">
             <Info flag="58" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -1857,7 +1857,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="lJXfIvEDs0a_UebENCcqxQ" name="Partition coefficient (neutral lipids/blood cells water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Schmitt.PARAM_K_n_L_rbc" isDefault="1">
+          <Parameter id="l1qi0pX0bkmtvKzqzDpt1g" name="Partition coefficient (neutral lipids/blood cells water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Schmitt.PARAM_K_n_L_rbc" isDefault="1">
             <Info flag="58" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -1867,7 +1867,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="qjYutjv4GUiDniEGO6B09g" name="Partition coefficient (neutral phospholipids/blood cells water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Schmitt.PARAM_K_n_PL_rbc" isDefault="1">
+          <Parameter id="MmNvh1-KuU2BxMt3MhNwlg" name="Partition coefficient (neutral phospholipids/blood cells water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Schmitt.PARAM_K_n_PL_rbc" isDefault="1">
             <Info flag="58" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -1877,7 +1877,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="Ifxm598oLkKs_NpsvUxw_Q" name="pKa_pH_WS_bc_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Schmitt.PARAM_pKa_pH_WS_bc_F1" isDefault="1">
+          <Parameter id="oQEameYVx0-ak3zte4RImw" name="pKa_pH_WS_bc_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Schmitt.PARAM_pKa_pH_WS_bc_F1" isDefault="1">
             <Info flag="52" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -1887,7 +1887,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="6XnzjzDbvU2yIUmll4AVUg" name="pKa_pH_WS_bc_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Schmitt.PARAM_pKa_pH_WS_bc_F2" isDefault="1">
+          <Parameter id="Q78oc70UCkeBmcGZyvYbaQ" name="pKa_pH_WS_bc_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Schmitt.PARAM_pKa_pH_WS_bc_F2" isDefault="1">
             <Info flag="52" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -1897,7 +1897,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="tXIRGt_Zl0KyAI4EkoS69w" name="pKa_pH_WS_bc_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Schmitt.PARAM_pKa_pH_WS_bc_F3" isDefault="1">
+          <Parameter id="mh49AtvnuUG93u2YY_MbYw" name="pKa_pH_WS_bc_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Schmitt.PARAM_pKa_pH_WS_bc_F3" isDefault="1">
             <Info flag="52" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -1907,7 +1907,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="Qu0M5aFr2EmLYVA8hYIK-w" name="pKa_pH_WS_bc_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Schmitt.PARAM_pKa_pH_WS_bc_K1" isDefault="1">
+          <Parameter id="vKxU6eBNSkCHmvRlpUDh1g" name="pKa_pH_WS_bc_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Schmitt.PARAM_pKa_pH_WS_bc_K1" isDefault="1">
             <Info flag="52" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -1917,7 +1917,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="Zhv1KTjASUSF7rtfamETFA" name="pKa_pH_WS_bc_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Schmitt.PARAM_pKa_pH_WS_bc_K2" isDefault="1">
+          <Parameter id="-UHPnXTHb0uXLsjJ3J7WcQ" name="pKa_pH_WS_bc_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Schmitt.PARAM_pKa_pH_WS_bc_K2" isDefault="1">
             <Info flag="52" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -1927,7 +1927,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="geQikUrMKEqeSozP7vS6aA" name="pKa_pH_WS_bc_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Schmitt.PARAM_pKa_pH_WS_bc_K3" isDefault="1">
+          <Parameter id="wOVrM79PIkCAeIRVLDCeAw" name="pKa_pH_WS_bc_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Schmitt.PARAM_pKa_pH_WS_bc_K3" isDefault="1">
             <Info flag="52" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -1937,7 +1937,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="QVhPeMhdxEuH5T69anvbxA" name="pKa_pH_WS_bc_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Schmitt.PARAM_pKa_pH_WS_bc_K4" isDefault="1">
+          <Parameter id="0qRCxRlmTEuoUU6DQE2UdQ" name="pKa_pH_WS_bc_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Schmitt.PARAM_pKa_pH_WS_bc_K4" isDefault="1">
             <Info flag="52" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -1947,7 +1947,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="QA8Ziy2vRkad9Nq49NmTUA" name="pKa_pH_WS_bc_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Schmitt.PARAM_pKa_pH_WS_bc_K5" isDefault="1">
+          <Parameter id="NjhJgjhA8keIX0Lu_TjRnw" name="pKa_pH_WS_bc_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Schmitt.PARAM_pKa_pH_WS_bc_K5" isDefault="1">
             <Info flag="52" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -1957,7 +1957,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="_A_kmAXlEUeHHO1cpB0XHg" name="pKa_pH_WS_bc_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Schmitt.PARAM_pKa_pH_WS_bc_K6" isDefault="1">
+          <Parameter id="t76w3QWPlk--RQOYrGYckg" name="pKa_pH_WS_bc_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Schmitt.PARAM_pKa_pH_WS_bc_K6" isDefault="1">
             <Info flag="52" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -1967,7 +1967,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="INUmoyt4Z0qs_fa6HTyxWQ" name="pKa_pH_WS_bc_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Schmitt.PARAM_pKa_pH_WS_bc_K7" isDefault="1">
+          <Parameter id="BtAcZ_1Il0iTm5YUEFXI6Q" name="pKa_pH_WS_bc_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Schmitt.PARAM_pKa_pH_WS_bc_K7" isDefault="1">
             <Info flag="52" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -1977,7 +1977,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="BRK1tuV6p0i4T2VaYPgueA" name="pKa_pH_WS_bc_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Schmitt.PARAM_pKa_pH_WS_bc_K8" isDefault="1">
+          <Parameter id="C0GersqDWk-DUtHUcRQGpQ" name="pKa_pH_WS_bc_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Schmitt.PARAM_pKa_pH_WS_bc_K8" isDefault="1">
             <Info flag="52" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -1987,7 +1987,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="Y5rXb1wcuEylmDGAMjaVpw" name="K_a_PL_pH_Factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Schmitt.PARAM_K_a_PL_pH_Factor" isDefault="1">
+          <Parameter id="HZ0RAXbvnkiheIlKNXH-lQ" name="K_a_PL_pH_Factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Schmitt.PARAM_K_a_PL_pH_Factor" isDefault="1">
             <Info flag="52" seq="1" ref="0" bb="2" group="68" />
           </Parameter>
           <DescriptorCriteria>
@@ -1997,7 +1997,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="dAP0iCfbS0uvpBhI9Rrbng" name="logD at pH (intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Log Units" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Schmitt.PARAM_LogD" isDefault="1" displayUnit="Log Units">
+          <Parameter id="7sN_vjqcIkeoTYg-mTLOeQ" name="logD at pH (intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Log Units" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Schmitt.PARAM_LogD" isDefault="1" displayUnit="Log Units">
             <Info flag="58" seq="1" ref="0" bb="2" group="73" />
           </Parameter>
           <DescriptorCriteria>
@@ -2007,7 +2007,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="jTKxcSlShUW1X9OuKqqw0Q" name="logD factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Schmitt.PARAM_logD_Factor" isDefault="1">
+          <Parameter id="oZQXACUdxUOZp0-iG0wb0g" name="logD factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Schmitt.PARAM_logD_Factor" isDefault="1">
             <Info flag="58" seq="1" ref="0" bb="2" group="73" />
           </Parameter>
           <DescriptorCriteria>
@@ -2017,7 +2017,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="GRdCQm7-3Uu5Vx6rch5yJQ" name="Partition coefficient (acidic phospholipids/intracellular water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Schmitt.PARAM_K_a_PL" isDefault="1">
+          <Parameter id="JqUFy19DhEiYXqUgNctYpQ" name="Partition coefficient (acidic phospholipids/intracellular water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Schmitt.PARAM_K_a_PL" isDefault="1">
             <Info flag="58" seq="1" ref="0" bb="2" group="68" />
           </Parameter>
           <DescriptorCriteria>
@@ -2027,7 +2027,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="LFrp6kSopEan7sNH2O06YA" name="Partition coefficient (neutral lipids/intracellular water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Schmitt.PARAM_K_n_L" isDefault="1">
+          <Parameter id="3Z6sPqyVZk-FL40vE4Aybw" name="Partition coefficient (neutral lipids/intracellular water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Schmitt.PARAM_K_n_L" isDefault="1">
             <Info flag="58" seq="1" ref="0" bb="2" group="71" />
           </Parameter>
           <DescriptorCriteria>
@@ -2037,7 +2037,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="39mh9N7tSUSxYi1jspoFYg" name="Partition coefficient (neutral phospholipids/intracellular water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Schmitt.PARAM_K_n_PL" isDefault="1">
+          <Parameter id="M1Uk0j6ZrkiRapSVv-Zx2w" name="Partition coefficient (neutral phospholipids/intracellular water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Schmitt.PARAM_K_n_PL" isDefault="1">
             <Info flag="58" seq="1" ref="0" bb="2" group="72" />
           </Parameter>
           <DescriptorCriteria>
@@ -2047,7 +2047,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="6v_8DtsdiEKwb9OYrkAUpw" name="pKa_pH_WS_cell_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Schmitt.PARAM_pKa_pH_WS_cell_F1" isDefault="1">
+          <Parameter id="IWhoJ5vR8EGj8nex7GGAFA" name="pKa_pH_WS_cell_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Schmitt.PARAM_pKa_pH_WS_cell_F1" isDefault="1">
             <Info flag="52" seq="1" ref="0" bb="2" group="75" />
           </Parameter>
           <DescriptorCriteria>
@@ -2057,7 +2057,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="SKZWsT8hPkCmEMUPmB2Gzw" name="pKa_pH_WS_cell_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Schmitt.PARAM_pKa_pH_WS_cell_F2" isDefault="1">
+          <Parameter id="-mOaoAOr9k-0fS3d4qsRWQ" name="pKa_pH_WS_cell_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Schmitt.PARAM_pKa_pH_WS_cell_F2" isDefault="1">
             <Info flag="52" seq="1" ref="0" bb="2" group="75" />
           </Parameter>
           <DescriptorCriteria>
@@ -2067,7 +2067,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="SxsCGiln6E6mAyZEDQgYGA" name="pKa_pH_WS_cell_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Schmitt.PARAM_pKa_pH_WS_cell_F3" isDefault="1">
+          <Parameter id="Hb3dM4vEd0aa10bpvVB_fA" name="pKa_pH_WS_cell_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Schmitt.PARAM_pKa_pH_WS_cell_F3" isDefault="1">
             <Info flag="52" seq="1" ref="0" bb="2" group="75" />
           </Parameter>
           <DescriptorCriteria>
@@ -2077,7 +2077,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="_LWRvKVW2UuCrxKf8Bu7sw" name="pKa_pH_WS_cell_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Schmitt.PARAM_pKa_pH_WS_cell_K1" isDefault="1">
+          <Parameter id="3oV3rMQJ3U2Z_tmqzXjI5A" name="pKa_pH_WS_cell_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Schmitt.PARAM_pKa_pH_WS_cell_K1" isDefault="1">
             <Info flag="52" seq="1" ref="0" bb="2" group="75" />
           </Parameter>
           <DescriptorCriteria>
@@ -2087,7 +2087,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="nP3kqk0lP0WaS8ZyNIbMtA" name="pKa_pH_WS_cell_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Schmitt.PARAM_pKa_pH_WS_cell_K2" isDefault="1">
+          <Parameter id="Kak5kNo2BkWJGvEy0IAoIw" name="pKa_pH_WS_cell_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Schmitt.PARAM_pKa_pH_WS_cell_K2" isDefault="1">
             <Info flag="52" seq="1" ref="0" bb="2" group="75" />
           </Parameter>
           <DescriptorCriteria>
@@ -2097,7 +2097,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="maw0h-BNy0uX6XfvfLrGiw" name="pKa_pH_WS_cell_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Schmitt.PARAM_pKa_pH_WS_cell_K3" isDefault="1">
+          <Parameter id="Z5G9B9s0FUKuvspAIp7Osg" name="pKa_pH_WS_cell_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Schmitt.PARAM_pKa_pH_WS_cell_K3" isDefault="1">
             <Info flag="52" seq="1" ref="0" bb="2" group="75" />
           </Parameter>
           <DescriptorCriteria>
@@ -2107,7 +2107,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="l0Qgsrd4s0u0K8XJNM4yJA" name="pKa_pH_WS_cell_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Schmitt.PARAM_pKa_pH_WS_cell_K4" isDefault="1">
+          <Parameter id="0jfDuj9MrEGAvjZEMgA1bw" name="pKa_pH_WS_cell_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Schmitt.PARAM_pKa_pH_WS_cell_K4" isDefault="1">
             <Info flag="52" seq="1" ref="0" bb="2" group="75" />
           </Parameter>
           <DescriptorCriteria>
@@ -2117,7 +2117,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="074vGybn_UKGX9Xk_cvATw" name="pKa_pH_WS_cell_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Schmitt.PARAM_pKa_pH_WS_cell_K5" isDefault="1">
+          <Parameter id="LjF0FFGBLEqvB3m7MBgOww" name="pKa_pH_WS_cell_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Schmitt.PARAM_pKa_pH_WS_cell_K5" isDefault="1">
             <Info flag="52" seq="1" ref="0" bb="2" group="75" />
           </Parameter>
           <DescriptorCriteria>
@@ -2127,7 +2127,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="n0CCxbP7PkGIFShAPbjOlg" name="pKa_pH_WS_cell_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Schmitt.PARAM_pKa_pH_WS_cell_K6" isDefault="1">
+          <Parameter id="mixZ-EXxlkmytIw3fvop2Q" name="pKa_pH_WS_cell_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Schmitt.PARAM_pKa_pH_WS_cell_K6" isDefault="1">
             <Info flag="52" seq="1" ref="0" bb="2" group="75" />
           </Parameter>
           <DescriptorCriteria>
@@ -2137,7 +2137,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="mqSNZjGPSkCKk1goWxnpTQ" name="pKa_pH_WS_cell_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Schmitt.PARAM_pKa_pH_WS_cell_K7" isDefault="1">
+          <Parameter id="1uV_0exqkUaCmu0hZJNDUA" name="pKa_pH_WS_cell_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Schmitt.PARAM_pKa_pH_WS_cell_K7" isDefault="1">
             <Info flag="52" seq="1" ref="0" bb="2" group="75" />
           </Parameter>
           <DescriptorCriteria>
@@ -2147,7 +2147,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="KHTUDBoJKkyuZwkf95JglA" name="pKa_pH_WS_cell_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Schmitt.PARAM_pKa_pH_WS_cell_K8" isDefault="1">
+          <Parameter id="zF_j4EM9m0iMfr9RLf3WoQ" name="pKa_pH_WS_cell_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular partition coefficient method - Schmitt.PARAM_pKa_pH_WS_cell_K8" isDefault="1">
             <Info flag="52" seq="1" ref="0" bb="2" group="75" />
           </Parameter>
           <DescriptorCriteria>
@@ -2187,10 +2187,10 @@
           </Formula>
           <Formula id="Cellular partition coefficient method - Schmitt.PARAM_logD_Factor_RBC" name="PARAM_logD_Factor_RBC" formula="K1+ (K2 +K3 +K4)* base ^ 1 + K5* base ^ max(CT0+CT1;-CT0-CT1) +K6* base ^ max(CT0+CT2;-CT0-CT2) +K7* base ^ max(CT2+CT1;-CT2-CT1) +K8* base ^ max(CT0+CT1+CT2;-CT0-CT1-CT2)">
             <Paths>
-              <Path path="72" as="38" />
+              <Path path="37" as="38" />
               <Path path="39" as="40" />
               <Path path="41" as="42" />
-              <Path path="43" as="44" />
+              <Path path="72" as="44" />
               <Path path="45" as="46" />
               <Path path="47" as="48" />
               <Path path="49" as="50" />
@@ -2223,24 +2223,24 @@
           </Formula>
           <Formula id="Cellular partition coefficient method - Schmitt.PARAM_pKa_pH_WS_bc_F1" name="PARAM_pKa_pH_WS_bc_F1" formula="CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1">
             <Paths>
-              <Path path="39" as="40" />
               <Path path="77" as="78" />
+              <Path path="37" as="38" />
               <Path path="79" as="65" />
               <Path path="70" as="80" />
             </Paths>
           </Formula>
           <Formula id="Cellular partition coefficient method - Schmitt.PARAM_pKa_pH_WS_bc_F2" name="PARAM_pKa_pH_WS_bc_F2" formula="CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1">
             <Paths>
-              <Path path="41" as="42" />
               <Path path="77" as="78" />
+              <Path path="39" as="40" />
               <Path path="81" as="67" />
               <Path path="70" as="80" />
             </Paths>
           </Formula>
           <Formula id="Cellular partition coefficient method - Schmitt.PARAM_pKa_pH_WS_bc_F3" name="PARAM_pKa_pH_WS_bc_F3" formula="CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1">
             <Paths>
-              <Path path="43" as="44" />
               <Path path="77" as="78" />
+              <Path path="41" as="42" />
               <Path path="82" as="69" />
               <Path path="70" as="80" />
             </Paths>
@@ -2337,10 +2337,10 @@
               <Path path="94" as="56" />
               <Path path="95" as="58" />
               <Path path="96" as="60" />
-              <Path path="103" as="38" />
+              <Path path="97" as="38" />
               <Path path="98" as="40" />
               <Path path="99" as="42" />
-              <Path path="100" as="44" />
+              <Path path="103" as="44" />
             </Paths>
           </Formula>
           <Formula id="Cellular partition coefficient method - Schmitt.PARAM_K_a_PL" name="PARAM_K_a_PL" formula="K_n_PL*K_a_PL_pH_Factor">
@@ -2366,24 +2366,24 @@
           <Formula id="Cellular partition coefficient method - Schmitt.PARAM_pKa_pH_WS_cell_F1" name="PARAM_pKa_pH_WS_cell_F1" formula="CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1">
             <Paths>
               <Path path="105" as="80" />
-              <Path path="98" as="40" />
               <Path path="106" as="78" />
+              <Path path="97" as="38" />
               <Path path="64" as="65" />
             </Paths>
           </Formula>
           <Formula id="Cellular partition coefficient method - Schmitt.PARAM_pKa_pH_WS_cell_F2" name="PARAM_pKa_pH_WS_cell_F2" formula="CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1">
             <Paths>
               <Path path="105" as="80" />
-              <Path path="99" as="42" />
               <Path path="106" as="78" />
+              <Path path="98" as="40" />
               <Path path="66" as="67" />
             </Paths>
           </Formula>
           <Formula id="Cellular partition coefficient method - Schmitt.PARAM_pKa_pH_WS_cell_F3" name="PARAM_pKa_pH_WS_cell_F3" formula="CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1">
             <Paths>
               <Path path="105" as="80" />
-              <Path path="100" as="44" />
               <Path path="106" as="78" />
+              <Path path="99" as="42" />
               <Path path="68" as="69" />
             </Paths>
           </Formula>
@@ -2482,14 +2482,14 @@
           <Map s="FIRST_NEIGHBOR|..|Vf (neutral phospholipid, plasma)-WS" id="34" />
           <Map s="FIRST_NEIGHBOR|..|Vf (protein)-WS" id="35" />
           <Map s="FIRST_NEIGHBOR|..|Vf (water)-WS" id="36" />
-          <Map s="..|base_For_KaPL_Factor" id="37" />
-          <Map s="base" id="38" />
-          <Map s="..|Compound type 0" id="39" />
-          <Map s="CT0" id="40" />
-          <Map s="..|Compound type 1" id="41" />
-          <Map s="CT1" id="42" />
-          <Map s="..|Compound type 2" id="43" />
-          <Map s="CT2" id="44" />
+          <Map s="..|Compound type 0" id="37" />
+          <Map s="CT0" id="38" />
+          <Map s="..|Compound type 1" id="39" />
+          <Map s="CT1" id="40" />
+          <Map s="..|Compound type 2" id="41" />
+          <Map s="CT2" id="42" />
+          <Map s="..|base_For_KaPL_Factor" id="43" />
+          <Map s="base" id="44" />
           <Map s="..|pKa_pH_WS_bc_K1" id="45" />
           <Map s="K1" id="46" />
           <Map s="..|pKa_pH_WS_bc_K2" id="47" />
@@ -2542,10 +2542,10 @@
           <Map s="..|pKa_pH_WS_cell_K6" id="94" />
           <Map s="..|pKa_pH_WS_cell_K7" id="95" />
           <Map s="..|pKa_pH_WS_cell_K8" id="96" />
-          <Map s="MOLECULE|base_For_KaPL_Factor" id="97" />
-          <Map s="MOLECULE|Compound type 0" id="98" />
-          <Map s="MOLECULE|Compound type 1" id="99" />
-          <Map s="MOLECULE|Compound type 2" id="100" />
+          <Map s="MOLECULE|Compound type 0" id="97" />
+          <Map s="MOLECULE|Compound type 1" id="98" />
+          <Map s="MOLECULE|Compound type 2" id="99" />
+          <Map s="MOLECULE|base_For_KaPL_Factor" id="100" />
           <Map s="SECOND_NEIGHBOR|pH" id="101" />
           <Map s="pH_cell" id="102" />
           <Map s="MOLECULE|base_For_logD_Factor" id="103" />
@@ -2559,10 +2559,10 @@
       </FormulaCache>
     </CoreCalculationMethod>
     <CoreCalculationMethod name="Cellular permeability - PK-Sim Standard" icon="CoreCalculationMethod" bbVersion="0" category="DiffusionIntCell">
-      <Creation createdAt="5248306844190455342" createdBy="EZZJY" creationMode="New" origin="Other" />
+      <Creation createdAt="5248852327098037310" createdBy="Michael" creationMode="New" origin="Other" />
       <OutputFormulas>
         <KeyValue>
-          <ConstantFormula id="fsSRXZUHBkiMhrQhmByTsA" value="1" />
+          <ConstantFormula id="LNmKGPGT8E6kTbeXhAYBmQ" value="1" />
           <ParameterDescriptor parameterName="P_bc_pls_factor">
             <ContainerCriteria>
               <DescriptorConditions>
@@ -2572,7 +2572,7 @@
           </ParameterDescriptor>
         </KeyValue>
         <KeyValue>
-          <ConstantFormula id="G__hidW1YUC9TaOMoTn6Yg" value="1" />
+          <ConstantFormula id="KaBmNLTY10i_zxNAWfti8g" value="1" />
           <ParameterDescriptor parameterName="P_pls_bc_factor">
             <ContainerCriteria>
               <DescriptorConditions>
@@ -2582,7 +2582,7 @@
           </ParameterDescriptor>
         </KeyValue>
         <KeyValue>
-          <ConstantFormula id="Fhjtclb9A0mNinYJjGDm1A" value="1" />
+          <ConstantFormula id="ZvUpMOZDwk6-h5zQoRUF1Q" value="1" />
           <ParameterDescriptor parameterName="P_cell_int_factor">
             <ContainerCriteria>
               <DescriptorConditions>
@@ -2592,7 +2592,7 @@
           </ParameterDescriptor>
         </KeyValue>
         <KeyValue>
-          <ConstantFormula id="zlPyoVC8QEqN8O1HTaFoQg" value="1" />
+          <ConstantFormula id="1OlVjDRo7EeEPfoXXJUkSw" value="1" />
           <ParameterDescriptor parameterName="P_int_cell_factor">
             <ContainerCriteria>
               <DescriptorConditions>
@@ -2605,7 +2605,7 @@
       <HelpParameters />
     </CoreCalculationMethod>
     <CoreCalculationMethod name="Cellular permeability - Charge dependent Schmitt" icon="CoreCalculationMethod" bbVersion="0" category="DiffusionIntCell">
-      <Creation createdAt="5248306844190465343" createdBy="EZZJY" creationMode="New" origin="Other" />
+      <Creation createdAt="5248852327098037310" createdBy="Michael" creationMode="New" origin="Other" />
       <OutputFormulas>
         <KeyValue>
           <Formula id="Cellular permeability - Charge dependent Schmitt.PARAM_P_rbc_pls_factor_WS" name="PARAM_P_rbc_pls_factor_WS" formula="K1+ (K2 +K3 +K4)* base ^ 1 + K5* base ^ max(CT0+CT1;-CT0-CT1) +K6* base ^ max(CT0+CT2;-CT0-CT2) +K7* base ^ max(CT2+CT1;-CT2-CT1) +K8* base ^ max(CT0+CT1+CT2;-CT0-CT1-CT2)">
@@ -2710,7 +2710,7 @@
       </OutputFormulas>
       <HelpParameters>
         <KeyValue>
-          <Parameter id="QtjtOze73EaKl9z7BryFDg" name="pKa_pH_WS_bc_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_bc_F1" isDefault="1">
+          <Parameter id="Ugm-woKBME2PYO91ufrJeA" name="pKa_pH_WS_bc_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_bc_F1" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -2720,7 +2720,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="1sZ4gxuEE0afBAWUaoTSRw" name="pKa_pH_WS_bc_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_bc_F2" isDefault="1">
+          <Parameter id="XLqJFvU-VECO85ovJs55Bw" name="pKa_pH_WS_bc_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_bc_F2" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -2730,7 +2730,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="Nb4LyFAr5UqZBCIHPl5Z5w" name="pKa_pH_WS_bc_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_bc_F3" isDefault="1">
+          <Parameter id="3-5NOn5omE-7iqXz6fnGdQ" name="pKa_pH_WS_bc_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_bc_F3" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -2740,7 +2740,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="4SjIgJhFxUWdCin3TKYrUg" name="pKa_pH_WS_bc_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_bc_K1" isDefault="1">
+          <Parameter id="NKWDY-Rt1UOrI-15QLuAfw" name="pKa_pH_WS_bc_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_bc_K1" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -2750,7 +2750,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="tjAGoBYKTkCLl7HO64d9pQ" name="pKa_pH_WS_bc_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_bc_K2" isDefault="1">
+          <Parameter id="XibsVxNrjEazeTPDBcx4eA" name="pKa_pH_WS_bc_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_bc_K2" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -2760,7 +2760,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="C1nj7q7Sf0u9OOEoZ4VB5A" name="pKa_pH_WS_bc_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_bc_K3" isDefault="1">
+          <Parameter id="TIjWjlSYrkuhewxGelh-jQ" name="pKa_pH_WS_bc_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_bc_K3" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -2770,7 +2770,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="kunQ_QpLxkiEcKjnVQbh8Q" name="pKa_pH_WS_bc_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_bc_K4" isDefault="1">
+          <Parameter id="gVazn870vEC1dKy4xpwFgw" name="pKa_pH_WS_bc_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_bc_K4" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -2780,7 +2780,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="NUjFD9FuX0ic9KjE8UNgPg" name="pKa_pH_WS_bc_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_bc_K5" isDefault="1">
+          <Parameter id="N3IRwWIu6ESg7MtB19PDug" name="pKa_pH_WS_bc_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_bc_K5" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -2790,7 +2790,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="ge3O-ce8YkmuHzz48v3pZw" name="pKa_pH_WS_bc_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_bc_K6" isDefault="1">
+          <Parameter id="H1T7OBteCkaFALTYD1Y7Pw" name="pKa_pH_WS_bc_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_bc_K6" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -2800,7 +2800,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="QUiQpXwESUa4KJVf35JsKg" name="pKa_pH_WS_bc_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_bc_K7" isDefault="1">
+          <Parameter id="ir9gfhg9rEuyme7DbEjbtw" name="pKa_pH_WS_bc_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_bc_K7" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -2810,7 +2810,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="RYhtXNLrokOaixZy9y5C5g" name="pKa_pH_WS_bc_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_bc_K8" isDefault="1">
+          <Parameter id="VJ_BrlDKCkK1F-I3vbO7ww" name="pKa_pH_WS_bc_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_bc_K8" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -2820,7 +2820,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="vaO3gVf7hke_Q7bWAjMQPA" name="pKa_pH_WS_pls_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_pls_F1" isDefault="1">
+          <Parameter id="zN_7jxyzmkeZghijOUFrgw" name="pKa_pH_WS_pls_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_pls_F1" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -2830,7 +2830,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="eKVn1eU470SflYHZECBanQ" name="pKa_pH_WS_pls_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_pls_F2" isDefault="1">
+          <Parameter id="9PDRmuzj90KlAu9RpBDM-w" name="pKa_pH_WS_pls_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_pls_F2" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -2840,7 +2840,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="iH_lauqIyEyN4obPDH52uw" name="pKa_pH_WS_pls_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_pls_F3" isDefault="1">
+          <Parameter id="EHuXAPzpE0GqXZlARsAYRg" name="pKa_pH_WS_pls_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_pls_F3" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -2850,7 +2850,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="cZOKEnajZ0aHI9jkZE6lAQ" name="pKa_pH_WS_pls_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_pls_K1" isDefault="1">
+          <Parameter id="s85iaR3ssEK0YWdZEyFNhg" name="pKa_pH_WS_pls_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_pls_K1" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -2860,7 +2860,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="B-cKuGqlD0SmOK9z3d7U0Q" name="pKa_pH_WS_pls_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_pls_K2" isDefault="1">
+          <Parameter id="kKut_RViW0Cf2EhHbrio4g" name="pKa_pH_WS_pls_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_pls_K2" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -2870,7 +2870,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="u4RzuLomKk-TlLOCbH9TyA" name="pKa_pH_WS_pls_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_pls_K3" isDefault="1">
+          <Parameter id="7Sn785Z3nUGPTiQPZmAOqA" name="pKa_pH_WS_pls_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_pls_K3" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -2880,7 +2880,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="3FO1cpJFck6HL57iM3WGEA" name="pKa_pH_WS_pls_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_pls_K4" isDefault="1">
+          <Parameter id="mJWTRsleAU-vlu6AyNzu0Q" name="pKa_pH_WS_pls_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_pls_K4" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -2890,7 +2890,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="MRK_4pp5sUaE_GD1fdGj8A" name="pKa_pH_WS_pls_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_pls_K5" isDefault="1">
+          <Parameter id="fb0FCdcx2kKuO0cQ40VO4Q" name="pKa_pH_WS_pls_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_pls_K5" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -2900,7 +2900,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="kP2VkgMA90m6O8BZmy0pFg" name="pKa_pH_WS_pls_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_pls_K6" isDefault="1">
+          <Parameter id="LvappNzPL0KWpf96Z4EFkw" name="pKa_pH_WS_pls_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_pls_K6" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -2910,7 +2910,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="VWn6kcG3O06bdz2NpryO_g" name="pKa_pH_WS_pls_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_pls_K7" isDefault="1">
+          <Parameter id="YP0nAlevtEiowoH3IA3HTQ" name="pKa_pH_WS_pls_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_pls_K7" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -2920,7 +2920,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="NzkI8CEbNkunoyuVbAbCAg" name="pKa_pH_WS_pls_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_pls_K8" isDefault="1">
+          <Parameter id="EnMo3vrpOEmV5jPZScIEiQ" name="pKa_pH_WS_pls_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_pls_K8" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -2930,7 +2930,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="7ff4gqch2UGE7ZTYjPxu0Q" name="pKa_pH_WS_cell_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_cell_F1" isDefault="1">
+          <Parameter id="mVbelr14H0KoG4Xp90cPQA" name="pKa_pH_WS_cell_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_cell_F1" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
           </Parameter>
           <DescriptorCriteria>
@@ -2940,7 +2940,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="pOx5RmR-r0K71ndy0WelFA" name="pKa_pH_WS_cell_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_cell_F2" isDefault="1">
+          <Parameter id="TlgAXSCCFUGWK4lJZo-MEQ" name="pKa_pH_WS_cell_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_cell_F2" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
           </Parameter>
           <DescriptorCriteria>
@@ -2950,7 +2950,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="8utxESCcnEWd5fWch99m2w" name="pKa_pH_WS_cell_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_cell_F3" isDefault="1">
+          <Parameter id="MhczW6GXL06KVVkBACEsRw" name="pKa_pH_WS_cell_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_cell_F3" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
           </Parameter>
           <DescriptorCriteria>
@@ -2960,7 +2960,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="uDb9eR_d50a95HPtRohdMQ" name="pKa_pH_WS_cell_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_cell_K1" isDefault="1">
+          <Parameter id="TW_7tXrPfkerMMEyycdbPw" name="pKa_pH_WS_cell_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_cell_K1" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
           </Parameter>
           <DescriptorCriteria>
@@ -2970,7 +2970,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="_2o9HV69FEaPL6uTukePUw" name="pKa_pH_WS_cell_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_cell_K2" isDefault="1">
+          <Parameter id="eQpUzIjQhEeffsz5BMFtOg" name="pKa_pH_WS_cell_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_cell_K2" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
           </Parameter>
           <DescriptorCriteria>
@@ -2980,7 +2980,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="dvApqAD7j0eD7SZZw7Tfnw" name="pKa_pH_WS_cell_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_cell_K3" isDefault="1">
+          <Parameter id="sjMvEjqCjEmHVl9MQrH6-w" name="pKa_pH_WS_cell_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_cell_K3" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
           </Parameter>
           <DescriptorCriteria>
@@ -2990,7 +2990,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="zD0bBBFHOE--ZryTzwVQPQ" name="pKa_pH_WS_cell_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_cell_K4" isDefault="1">
+          <Parameter id="DoVE9a2ljk60HVTEn8nWdg" name="pKa_pH_WS_cell_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_cell_K4" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
           </Parameter>
           <DescriptorCriteria>
@@ -3000,7 +3000,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="Q70OfEPKgEyqDvQANBVo4w" name="pKa_pH_WS_cell_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_cell_K5" isDefault="1">
+          <Parameter id="JxYiHKOaV0ei3OA0tgxV2g" name="pKa_pH_WS_cell_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_cell_K5" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
           </Parameter>
           <DescriptorCriteria>
@@ -3010,7 +3010,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="Srit64jnFEGONf8QiNCPcg" name="pKa_pH_WS_cell_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_cell_K6" isDefault="1">
+          <Parameter id="EFMIOpvQskWoJoFiJUQO9Q" name="pKa_pH_WS_cell_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_cell_K6" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
           </Parameter>
           <DescriptorCriteria>
@@ -3020,7 +3020,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="JoSZ0LpOE0OqOBg_Sp3obA" name="pKa_pH_WS_cell_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_cell_K7" isDefault="1">
+          <Parameter id="XW3YSvBu40mf8QnPcClcMg" name="pKa_pH_WS_cell_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_cell_K7" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
           </Parameter>
           <DescriptorCriteria>
@@ -3030,7 +3030,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="lMrom1zl2UG5i-J0cixX1w" name="pKa_pH_WS_cell_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_cell_K8" isDefault="1">
+          <Parameter id="ZOjb4AL-qkGYzX0elFjspg" name="pKa_pH_WS_cell_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_cell_K8" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
           </Parameter>
           <DescriptorCriteria>
@@ -3040,7 +3040,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="b1wM4eZgtUW6JOx_smprZg" name="pKa_pH_WS_int_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_int_F1" isDefault="1">
+          <Parameter id="x9PA2WdktEuyw8L0u4X26g" name="pKa_pH_WS_int_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_int_F1" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -3050,7 +3050,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="R2oDD5Xs-EOyhmePvPnBIw" name="pKa_pH_WS_int_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_int_F2" isDefault="1">
+          <Parameter id="Rh-v3aHMY0Ol3DzrXoVrBA" name="pKa_pH_WS_int_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_int_F2" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -3060,7 +3060,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="DIZP3p9dZE22f0PJQ2w_CA" name="pKa_pH_WS_int_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_int_F3" isDefault="1">
+          <Parameter id="2sLcDYjWvUqG0uQnX-e1Tg" name="pKa_pH_WS_int_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_int_F3" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -3070,7 +3070,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="3cFpqOOF2Ue92Vzujp09Xg" name="pKa_pH_WS_int_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_int_K1" isDefault="1">
+          <Parameter id="h4BHxhG23Ee4trlOXxRujg" name="pKa_pH_WS_int_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_int_K1" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -3080,7 +3080,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="wUp2qJkbB0yhFNfit-BApA" name="pKa_pH_WS_int_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_int_K2" isDefault="1">
+          <Parameter id="0pd3V_uhtUSvTitD0-vOLw" name="pKa_pH_WS_int_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_int_K2" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -3090,7 +3090,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="8NgFzUzx9UOQVEBIjEf68A" name="pKa_pH_WS_int_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_int_K3" isDefault="1">
+          <Parameter id="eQ8vRrOYnUCNIDjkLk8gUQ" name="pKa_pH_WS_int_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_int_K3" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -3100,7 +3100,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="vG6jQycwZ02-xH6PLkC4tQ" name="pKa_pH_WS_int_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_int_K4" isDefault="1">
+          <Parameter id="fuLDq_jLfES4vTaC12KeIQ" name="pKa_pH_WS_int_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_int_K4" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -3110,7 +3110,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="VO-alFPSxkKpGxJwqqCG_g" name="pKa_pH_WS_int_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_int_K5" isDefault="1">
+          <Parameter id="25E-kkBnuEK-CpM4clFLsQ" name="pKa_pH_WS_int_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_int_K5" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -3120,7 +3120,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="wL7H2wzzskWrsh2gYG-_9g" name="pKa_pH_WS_int_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_int_K6" isDefault="1">
+          <Parameter id="fSQ4gY4G-kumFV4-DMeBrg" name="pKa_pH_WS_int_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_int_K6" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -3130,7 +3130,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="XGuQzlvji0WB1vhn5psH_w" name="pKa_pH_WS_int_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_int_K7" isDefault="1">
+          <Parameter id="6UDfbbUZGEeVpK0BgIyiqQ" name="pKa_pH_WS_int_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_int_K7" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -3140,7 +3140,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="Y_c7MBPibEGdMIvnUJDTWQ" name="pKa_pH_WS_int_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_int_K8" isDefault="1">
+          <Parameter id="sciu7VVtzUG6u0K70t-xEg" name="pKa_pH_WS_int_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_int_K8" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -3154,24 +3154,24 @@
         <Formulas>
           <Formula id="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_bc_F1" name="PARAM_pKa_pH_WS_bc_F1" formula="CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1">
             <Paths>
-              <Path path="2" as="3" />
               <Path path="52" as="53" />
+              <Path path="0" as="1" />
               <Path path="54" as="55" />
               <Path path="56" as="57" />
             </Paths>
           </Formula>
           <Formula id="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_bc_F2" name="PARAM_pKa_pH_WS_bc_F2" formula="CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1">
             <Paths>
-              <Path path="4" as="5" />
               <Path path="52" as="53" />
+              <Path path="2" as="3" />
               <Path path="58" as="59" />
               <Path path="56" as="57" />
             </Paths>
           </Formula>
           <Formula id="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_bc_F3" name="PARAM_pKa_pH_WS_bc_F3" formula="CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1">
             <Paths>
-              <Path path="6" as="7" />
               <Path path="52" as="53" />
+              <Path path="4" as="5" />
               <Path path="60" as="61" />
               <Path path="56" as="57" />
             </Paths>
@@ -3234,24 +3234,24 @@
           </Formula>
           <Formula id="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_pls_F1" name="PARAM_pKa_pH_WS_pls_F1" formula="CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1">
             <Paths>
-              <Path path="2" as="3" />
               <Path path="52" as="53" />
+              <Path path="0" as="1" />
               <Path path="54" as="55" />
               <Path path="68" as="57" />
             </Paths>
           </Formula>
           <Formula id="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_pls_F2" name="PARAM_pKa_pH_WS_pls_F2" formula="CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1">
             <Paths>
-              <Path path="4" as="5" />
               <Path path="52" as="53" />
+              <Path path="2" as="3" />
               <Path path="58" as="59" />
               <Path path="68" as="57" />
             </Paths>
           </Formula>
           <Formula id="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_pls_F3" name="PARAM_pKa_pH_WS_pls_F3" formula="CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1">
             <Paths>
-              <Path path="6" as="7" />
               <Path path="52" as="53" />
+              <Path path="4" as="5" />
               <Path path="60" as="61" />
               <Path path="68" as="57" />
             </Paths>
@@ -3315,24 +3315,24 @@
           <Formula id="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_cell_F1" name="PARAM_pKa_pH_WS_cell_F1" formula="CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1">
             <Paths>
               <Path path="72" as="57" />
-              <Path path="41" as="3" />
               <Path path="73" as="53" />
+              <Path path="40" as="1" />
               <Path path="74" as="55" />
             </Paths>
           </Formula>
           <Formula id="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_cell_F2" name="PARAM_pKa_pH_WS_cell_F2" formula="CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1">
             <Paths>
               <Path path="72" as="57" />
-              <Path path="42" as="5" />
               <Path path="73" as="53" />
+              <Path path="41" as="3" />
               <Path path="75" as="59" />
             </Paths>
           </Formula>
           <Formula id="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_cell_F3" name="PARAM_pKa_pH_WS_cell_F3" formula="CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1">
             <Paths>
               <Path path="72" as="57" />
-              <Path path="43" as="7" />
               <Path path="73" as="53" />
+              <Path path="42" as="5" />
               <Path path="76" as="61" />
             </Paths>
           </Formula>
@@ -3395,24 +3395,24 @@
           <Formula id="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_int_F1" name="PARAM_pKa_pH_WS_int_F1" formula="CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1">
             <Paths>
               <Path path="80" as="57" />
-              <Path path="41" as="3" />
               <Path path="73" as="53" />
+              <Path path="40" as="1" />
               <Path path="74" as="55" />
             </Paths>
           </Formula>
           <Formula id="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_int_F2" name="PARAM_pKa_pH_WS_int_F2" formula="CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1">
             <Paths>
               <Path path="80" as="57" />
-              <Path path="42" as="5" />
               <Path path="73" as="53" />
+              <Path path="41" as="3" />
               <Path path="75" as="59" />
             </Paths>
           </Formula>
           <Formula id="Cellular permeability - Charge dependent Schmitt.PARAM_pKa_pH_WS_int_F3" name="PARAM_pKa_pH_WS_int_F3" formula="CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1">
             <Paths>
               <Path path="80" as="57" />
-              <Path path="43" as="7" />
               <Path path="73" as="53" />
+              <Path path="42" as="5" />
               <Path path="76" as="61" />
             </Paths>
           </Formula>
@@ -3474,14 +3474,14 @@
           </Formula>
         </Formulas>
         <StringMap>
-          <Map s="..|base_For_P_cell_Factor" id="0" />
-          <Map s="base" id="1" />
-          <Map s="..|Compound type 0" id="2" />
-          <Map s="CT0" id="3" />
-          <Map s="..|Compound type 1" id="4" />
-          <Map s="CT1" id="5" />
-          <Map s="..|Compound type 2" id="6" />
-          <Map s="CT2" id="7" />
+          <Map s="..|Compound type 0" id="0" />
+          <Map s="CT0" id="1" />
+          <Map s="..|Compound type 1" id="2" />
+          <Map s="CT1" id="3" />
+          <Map s="..|Compound type 2" id="4" />
+          <Map s="CT2" id="5" />
+          <Map s="..|base_For_P_cell_Factor" id="6" />
+          <Map s="base" id="7" />
           <Map s="..|pKa_pH_WS_bc_K1" id="8" />
           <Map s="K1" id="9" />
           <Map s="..|pKa_pH_WS_bc_K2" id="10" />
@@ -3514,10 +3514,10 @@
           <Map s="..|pKa_pH_WS_cell_K6" id="37" />
           <Map s="..|pKa_pH_WS_cell_K7" id="38" />
           <Map s="..|pKa_pH_WS_cell_K8" id="39" />
-          <Map s="MOLECULE|base_For_P_cell_Factor" id="40" />
-          <Map s="MOLECULE|Compound type 0" id="41" />
-          <Map s="MOLECULE|Compound type 1" id="42" />
-          <Map s="MOLECULE|Compound type 2" id="43" />
+          <Map s="MOLECULE|Compound type 0" id="40" />
+          <Map s="MOLECULE|Compound type 1" id="41" />
+          <Map s="MOLECULE|Compound type 2" id="42" />
+          <Map s="MOLECULE|base_For_P_cell_Factor" id="43" />
           <Map s="..|pKa_pH_WS_int_K1" id="44" />
           <Map s="..|pKa_pH_WS_int_K2" id="45" />
           <Map s="..|pKa_pH_WS_int_K3" id="46" />
@@ -3562,7 +3562,7 @@
       </FormulaCache>
     </CoreCalculationMethod>
     <CoreCalculationMethod name="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim" icon="CoreCalculationMethod" bbVersion="0" category="DiffusionIntCell">
-      <Creation createdAt="5248306844190485344" createdBy="EZZJY" creationMode="New" origin="Other" />
+      <Creation createdAt="5248852327098057259" createdBy="Michael" creationMode="New" origin="Other" />
       <OutputFormulas>
         <KeyValue>
           <Formula id="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_P_rbc_pls_factor_WS" name="PARAM_P_rbc_pls_factor_WS" formula="K1+ (K2 +K3 +K4)* base ^ 1 + K5* base ^ max(CT0+CT1;-CT0-CT1) +K6* base ^ max(CT0+CT2;-CT0-CT2) +K7* base ^ max(CT2+CT1;-CT2-CT1) +K8* base ^ max(CT0+CT1+CT2;-CT0-CT1-CT2)">
@@ -3667,7 +3667,7 @@
       </OutputFormulas>
       <HelpParameters>
         <KeyValue>
-          <Parameter id="Z2vx7vv7S0GEzN_Zaut4qg" name="pKa_pH_WS_bc_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_bc_F1" isDefault="1">
+          <Parameter id="QGXt4pWmK0OZMby8mo4FCw" name="pKa_pH_WS_bc_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_bc_F1" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -3677,7 +3677,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="xVN3WwkPfkitsSunSjG7Ug" name="pKa_pH_WS_bc_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_bc_F2" isDefault="1">
+          <Parameter id="UJj4fKtQ0kivNhYPCNK94g" name="pKa_pH_WS_bc_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_bc_F2" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -3687,7 +3687,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="JORd7Lh9DkSJMMIje6LBBg" name="pKa_pH_WS_bc_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_bc_F3" isDefault="1">
+          <Parameter id="GdIHWTZZ5EWFPrWLKRxsDA" name="pKa_pH_WS_bc_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_bc_F3" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -3697,7 +3697,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="lx3iZy80302j52fTASpIvA" name="pKa_pH_WS_bc_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_bc_K1" isDefault="1">
+          <Parameter id="Z6cuscwFbUihDK71SNPw5w" name="pKa_pH_WS_bc_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_bc_K1" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -3707,7 +3707,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="lVQa0mOuZU2bSOpMJN8B8w" name="pKa_pH_WS_bc_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_bc_K2" isDefault="1">
+          <Parameter id="wtu7u4eVTkGdaBCEGxyxTg" name="pKa_pH_WS_bc_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_bc_K2" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -3717,7 +3717,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="6IFnNqwm0kOOoSMrWBEjqA" name="pKa_pH_WS_bc_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_bc_K3" isDefault="1">
+          <Parameter id="OAfST6S57EG76YqGkdi0-g" name="pKa_pH_WS_bc_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_bc_K3" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -3727,7 +3727,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="dGBCFa7g5Em7Iy5fPn_3fQ" name="pKa_pH_WS_bc_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_bc_K4" isDefault="1">
+          <Parameter id="_LhLQCCpm0WQyWsEG5P0Vw" name="pKa_pH_WS_bc_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_bc_K4" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -3737,7 +3737,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="lwhwGYQdsUS4BR9XzNCekA" name="pKa_pH_WS_bc_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_bc_K5" isDefault="1">
+          <Parameter id="WXY_kAPoI0mDtsCDhezSEw" name="pKa_pH_WS_bc_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_bc_K5" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -3747,7 +3747,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="mjMYq22Lp0C9njLEr0H0-Q" name="pKa_pH_WS_bc_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_bc_K6" isDefault="1">
+          <Parameter id="5zz_H4TJ-0qnLe35ClOBfg" name="pKa_pH_WS_bc_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_bc_K6" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -3757,7 +3757,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="ni0SrT12hUGO1D-sbO25lg" name="pKa_pH_WS_bc_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_bc_K7" isDefault="1">
+          <Parameter id="f8UuT-XTvE-JW_DvH20-KA" name="pKa_pH_WS_bc_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_bc_K7" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -3767,7 +3767,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="lRKJ4ZWVrESkif8-zyEjPA" name="pKa_pH_WS_bc_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_bc_K8" isDefault="1">
+          <Parameter id="BkYkLsbQPEW-gtqpmmXK4Q" name="pKa_pH_WS_bc_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_bc_K8" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -3777,7 +3777,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="c7v-kRcgX0WIhtlRVSQKLw" name="pKa_pH_WS_pls_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_pls_F1" isDefault="1">
+          <Parameter id="p7x0QCXw2Uex10wFaxL7Ng" name="pKa_pH_WS_pls_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_pls_F1" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -3787,7 +3787,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="YrhJUt971UWVzbQfJw7G7w" name="pKa_pH_WS_pls_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_pls_F2" isDefault="1">
+          <Parameter id="rAZy2oJSPEODlZe6UfA3UQ" name="pKa_pH_WS_pls_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_pls_F2" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -3797,7 +3797,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="_kzdWk-E7kaAVuaMda1GYw" name="pKa_pH_WS_pls_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_pls_F3" isDefault="1">
+          <Parameter id="Z0tQxM1wrkOokBIMWa8wQQ" name="pKa_pH_WS_pls_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_pls_F3" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -3807,7 +3807,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="0GcdfsT3pEuJWhYTgN48fQ" name="pKa_pH_WS_pls_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_pls_K1" isDefault="1">
+          <Parameter id="Et-Im5btFku4yLycKtjaoA" name="pKa_pH_WS_pls_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_pls_K1" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -3817,7 +3817,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="fO2R0HlZ50S6HytcC1PJbg" name="pKa_pH_WS_pls_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_pls_K2" isDefault="1">
+          <Parameter id="LE4zdjU_sUmlcfsEARAh-w" name="pKa_pH_WS_pls_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_pls_K2" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -3827,7 +3827,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="DS-W7OIIrkWHHmD3dmoXgQ" name="pKa_pH_WS_pls_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_pls_K3" isDefault="1">
+          <Parameter id="UgMwp2kExki00D-T4mz8zA" name="pKa_pH_WS_pls_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_pls_K3" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -3837,7 +3837,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="_-tFHHw2GkiR094mRJNd7w" name="pKa_pH_WS_pls_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_pls_K4" isDefault="1">
+          <Parameter id="HEinNSiV5kKFPhl88fsKMw" name="pKa_pH_WS_pls_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_pls_K4" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -3847,7 +3847,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="tzaaG-R_k0eJ3od63z9Gbw" name="pKa_pH_WS_pls_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_pls_K5" isDefault="1">
+          <Parameter id="cpCfT-QD7kCFZi9teV1IOQ" name="pKa_pH_WS_pls_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_pls_K5" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -3857,7 +3857,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="oUHnKnhgbkS5y83-IA7uhA" name="pKa_pH_WS_pls_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_pls_K6" isDefault="1">
+          <Parameter id="N1NY5Y3UDkem2CrP6kzAmg" name="pKa_pH_WS_pls_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_pls_K6" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -3867,7 +3867,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="uQ-V6Ffk9kyjrh0RlB6dwA" name="pKa_pH_WS_pls_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_pls_K7" isDefault="1">
+          <Parameter id="KMCLaMMLLkqak3LZLJWVZQ" name="pKa_pH_WS_pls_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_pls_K7" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -3877,7 +3877,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="2VTFXD-lkEGssqsghOT7tg" name="pKa_pH_WS_pls_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_pls_K8" isDefault="1">
+          <Parameter id="BywlqxB1kkK7fGbiOSIj9w" name="pKa_pH_WS_pls_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_pls_K8" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -3887,7 +3887,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="Rb3WriCeAE-gHzjfaybhGQ" name="pKa_pH_WS_cell_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_cell_F1" isDefault="1">
+          <Parameter id="6ePD7EwjE0y_KI1Z4twsMg" name="pKa_pH_WS_cell_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_cell_F1" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
           </Parameter>
           <DescriptorCriteria>
@@ -3897,7 +3897,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="JLjM-AOmoEWNjtL7b7A6kg" name="pKa_pH_WS_cell_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_cell_F2" isDefault="1">
+          <Parameter id="YHR-E__gHkC_EgANq_4xNg" name="pKa_pH_WS_cell_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_cell_F2" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
           </Parameter>
           <DescriptorCriteria>
@@ -3907,7 +3907,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="azSa-fQtPEGPl7XGu380CQ" name="pKa_pH_WS_cell_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_cell_F3" isDefault="1">
+          <Parameter id="QplBy3AyEkaI98GONCbSWg" name="pKa_pH_WS_cell_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_cell_F3" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
           </Parameter>
           <DescriptorCriteria>
@@ -3917,7 +3917,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="6O_NI1VtKE6NYLPdR9pqGQ" name="pKa_pH_WS_cell_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_cell_K1" isDefault="1">
+          <Parameter id="RF-UBz7U106GfwtzOwL5uw" name="pKa_pH_WS_cell_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_cell_K1" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
           </Parameter>
           <DescriptorCriteria>
@@ -3927,7 +3927,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="Wp0ONp_R1kG31b_vS0RmOQ" name="pKa_pH_WS_cell_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_cell_K2" isDefault="1">
+          <Parameter id="SWi6VE5Vi06CUYngP2LuWA" name="pKa_pH_WS_cell_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_cell_K2" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
           </Parameter>
           <DescriptorCriteria>
@@ -3937,7 +3937,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="6hqXLy1Mb0-IwiyTG6eKHA" name="pKa_pH_WS_cell_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_cell_K3" isDefault="1">
+          <Parameter id="f2Wd-jCZhEaEtfucCDUwCQ" name="pKa_pH_WS_cell_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_cell_K3" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
           </Parameter>
           <DescriptorCriteria>
@@ -3947,7 +3947,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="Nlpl7FsKv0-o3Ha8Y5C3aA" name="pKa_pH_WS_cell_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_cell_K4" isDefault="1">
+          <Parameter id="DwTnyoDyQ0qRy4T12ky6iA" name="pKa_pH_WS_cell_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_cell_K4" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
           </Parameter>
           <DescriptorCriteria>
@@ -3957,7 +3957,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="Gy_KFkO4nUS30lGSZujeEg" name="pKa_pH_WS_cell_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_cell_K5" isDefault="1">
+          <Parameter id="OFs810cNo0qPEuQbSiLOpA" name="pKa_pH_WS_cell_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_cell_K5" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
           </Parameter>
           <DescriptorCriteria>
@@ -3967,7 +3967,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="bQL5NX7gt0uI6xm9XwyykQ" name="pKa_pH_WS_cell_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_cell_K6" isDefault="1">
+          <Parameter id="NnR9Ms_HAkKSlW25cMY9HQ" name="pKa_pH_WS_cell_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_cell_K6" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
           </Parameter>
           <DescriptorCriteria>
@@ -3977,7 +3977,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="G7E8Da4TKUejy4ymVBjtxA" name="pKa_pH_WS_cell_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_cell_K7" isDefault="1">
+          <Parameter id="VHoWcRKH80CG4vGC8Jy8BQ" name="pKa_pH_WS_cell_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_cell_K7" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
           </Parameter>
           <DescriptorCriteria>
@@ -3987,7 +3987,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="HopJ4A9gmkuzvwidJzNLEQ" name="pKa_pH_WS_cell_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_cell_K8" isDefault="1">
+          <Parameter id="HOLw_PFsVEmqFIideLSC-g" name="pKa_pH_WS_cell_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_cell_K8" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
           </Parameter>
           <DescriptorCriteria>
@@ -3997,7 +3997,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="4AX3bvODT0ytDAZa1o02yw" name="pKa_pH_WS_int_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_int_F1" isDefault="1">
+          <Parameter id="3o7wrYQ8uUi8lGw3ts6RzA" name="pKa_pH_WS_int_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_int_F1" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -4007,7 +4007,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="dgBbiuneuEmf0-XJkwJ9tg" name="pKa_pH_WS_int_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_int_F2" isDefault="1">
+          <Parameter id="csusTUT-ckSbeeV_vp1F0Q" name="pKa_pH_WS_int_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_int_F2" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -4017,7 +4017,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="hucujrw5-0KrfZIiUuhsTQ" name="pKa_pH_WS_int_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_int_F3" isDefault="1">
+          <Parameter id="eE-gpI4gtUOx_ls-577IWA" name="pKa_pH_WS_int_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_int_F3" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -4027,7 +4027,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="zwEO3lv3v062z5KUrEU5MQ" name="pKa_pH_WS_int_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_int_K1" isDefault="1">
+          <Parameter id="5No0O7KKwUu0EBqkWig-SQ" name="pKa_pH_WS_int_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_int_K1" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -4037,7 +4037,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="GUyElybfQ0ucbXWtHSrIng" name="pKa_pH_WS_int_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_int_K2" isDefault="1">
+          <Parameter id="aVoef_Ud4UqEn_FuGFtPIw" name="pKa_pH_WS_int_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_int_K2" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -4047,7 +4047,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="phCMtdSlEkyZVXs_KFtQ5A" name="pKa_pH_WS_int_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_int_K3" isDefault="1">
+          <Parameter id="1Cm4cgUeTEmX9DvG0mpMMw" name="pKa_pH_WS_int_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_int_K3" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -4057,7 +4057,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="XVbL7yckNkOjjya5GitOxg" name="pKa_pH_WS_int_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_int_K4" isDefault="1">
+          <Parameter id="hgvKNsA-wEeCrjehWx_CTQ" name="pKa_pH_WS_int_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_int_K4" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -4067,7 +4067,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="pHT2eMMz6EKBJ4BnLOGttw" name="pKa_pH_WS_int_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_int_K5" isDefault="1">
+          <Parameter id="RfOiGc4xREafvmszRykaQg" name="pKa_pH_WS_int_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_int_K5" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -4077,7 +4077,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="AhdNQUFBFkqVqk6us_EtRg" name="pKa_pH_WS_int_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_int_K6" isDefault="1">
+          <Parameter id="mS7DmuyXfk-JlsPcRkqU3A" name="pKa_pH_WS_int_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_int_K6" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -4087,7 +4087,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="sqjCMNGRJkO6hsdiX-0B1A" name="pKa_pH_WS_int_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_int_K7" isDefault="1">
+          <Parameter id="x7PT3A0zaUC3Q3J4T666Iw" name="pKa_pH_WS_int_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_int_K7" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -4097,7 +4097,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="kg7T5zvg3kehi-DX1A6FcA" name="pKa_pH_WS_int_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_int_K8" isDefault="1">
+          <Parameter id="xkJqKktr70-TCObOjTNTfQ" name="pKa_pH_WS_int_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_int_K8" isDefault="1">
             <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="67" />
           </Parameter>
           <DescriptorCriteria>
@@ -4111,24 +4111,24 @@
         <Formulas>
           <Formula id="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_bc_F1" name="PARAM_pKa_pH_WS_bc_F1" formula="CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1">
             <Paths>
-              <Path path="2" as="3" />
               <Path path="52" as="53" />
+              <Path path="0" as="1" />
               <Path path="54" as="55" />
               <Path path="56" as="57" />
             </Paths>
           </Formula>
           <Formula id="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_bc_F2" name="PARAM_pKa_pH_WS_bc_F2" formula="CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1">
             <Paths>
-              <Path path="4" as="5" />
               <Path path="52" as="53" />
+              <Path path="2" as="3" />
               <Path path="58" as="59" />
               <Path path="56" as="57" />
             </Paths>
           </Formula>
           <Formula id="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_bc_F3" name="PARAM_pKa_pH_WS_bc_F3" formula="CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1">
             <Paths>
-              <Path path="6" as="7" />
               <Path path="52" as="53" />
+              <Path path="4" as="5" />
               <Path path="60" as="61" />
               <Path path="56" as="57" />
             </Paths>
@@ -4191,24 +4191,24 @@
           </Formula>
           <Formula id="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_pls_F1" name="PARAM_pKa_pH_WS_pls_F1" formula="CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1">
             <Paths>
-              <Path path="2" as="3" />
               <Path path="52" as="53" />
+              <Path path="0" as="1" />
               <Path path="54" as="55" />
               <Path path="68" as="57" />
             </Paths>
           </Formula>
           <Formula id="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_pls_F2" name="PARAM_pKa_pH_WS_pls_F2" formula="CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1">
             <Paths>
-              <Path path="4" as="5" />
               <Path path="52" as="53" />
+              <Path path="2" as="3" />
               <Path path="58" as="59" />
               <Path path="68" as="57" />
             </Paths>
           </Formula>
           <Formula id="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_pls_F3" name="PARAM_pKa_pH_WS_pls_F3" formula="CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1">
             <Paths>
-              <Path path="6" as="7" />
               <Path path="52" as="53" />
+              <Path path="4" as="5" />
               <Path path="60" as="61" />
               <Path path="68" as="57" />
             </Paths>
@@ -4272,24 +4272,24 @@
           <Formula id="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_cell_F1" name="PARAM_pKa_pH_WS_cell_F1" formula="CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1">
             <Paths>
               <Path path="72" as="57" />
-              <Path path="41" as="3" />
               <Path path="73" as="53" />
+              <Path path="40" as="1" />
               <Path path="74" as="55" />
             </Paths>
           </Formula>
           <Formula id="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_cell_F2" name="PARAM_pKa_pH_WS_cell_F2" formula="CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1">
             <Paths>
               <Path path="72" as="57" />
-              <Path path="42" as="5" />
               <Path path="73" as="53" />
+              <Path path="41" as="3" />
               <Path path="75" as="59" />
             </Paths>
           </Formula>
           <Formula id="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_cell_F3" name="PARAM_pKa_pH_WS_cell_F3" formula="CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1">
             <Paths>
               <Path path="72" as="57" />
-              <Path path="43" as="7" />
               <Path path="73" as="53" />
+              <Path path="42" as="5" />
               <Path path="76" as="61" />
             </Paths>
           </Formula>
@@ -4352,24 +4352,24 @@
           <Formula id="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_int_F1" name="PARAM_pKa_pH_WS_int_F1" formula="CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1">
             <Paths>
               <Path path="80" as="57" />
-              <Path path="41" as="3" />
               <Path path="73" as="53" />
+              <Path path="40" as="1" />
               <Path path="74" as="55" />
             </Paths>
           </Formula>
           <Formula id="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_int_F2" name="PARAM_pKa_pH_WS_int_F2" formula="CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1">
             <Paths>
               <Path path="80" as="57" />
-              <Path path="42" as="5" />
               <Path path="73" as="53" />
+              <Path path="41" as="3" />
               <Path path="75" as="59" />
             </Paths>
           </Formula>
           <Formula id="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim.PARAM_pKa_pH_WS_int_F3" name="PARAM_pKa_pH_WS_int_F3" formula="CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1">
             <Paths>
               <Path path="80" as="57" />
-              <Path path="43" as="7" />
               <Path path="73" as="53" />
+              <Path path="42" as="5" />
               <Path path="76" as="61" />
             </Paths>
           </Formula>
@@ -4431,14 +4431,14 @@
           </Formula>
         </Formulas>
         <StringMap>
-          <Map s="..|base_For_P_cell_Factor" id="0" />
-          <Map s="base" id="1" />
-          <Map s="..|Compound type 0" id="2" />
-          <Map s="CT0" id="3" />
-          <Map s="..|Compound type 1" id="4" />
-          <Map s="CT1" id="5" />
-          <Map s="..|Compound type 2" id="6" />
-          <Map s="CT2" id="7" />
+          <Map s="..|Compound type 0" id="0" />
+          <Map s="CT0" id="1" />
+          <Map s="..|Compound type 1" id="2" />
+          <Map s="CT1" id="3" />
+          <Map s="..|Compound type 2" id="4" />
+          <Map s="CT2" id="5" />
+          <Map s="..|base_For_P_cell_Factor" id="6" />
+          <Map s="base" id="7" />
           <Map s="..|pKa_pH_WS_bc_K1" id="8" />
           <Map s="K1" id="9" />
           <Map s="..|pKa_pH_WS_bc_K2" id="10" />
@@ -4471,10 +4471,10 @@
           <Map s="..|pKa_pH_WS_cell_K6" id="37" />
           <Map s="..|pKa_pH_WS_cell_K7" id="38" />
           <Map s="..|pKa_pH_WS_cell_K8" id="39" />
-          <Map s="MOLECULE|base_For_P_cell_Factor" id="40" />
-          <Map s="MOLECULE|Compound type 0" id="41" />
-          <Map s="MOLECULE|Compound type 1" id="42" />
-          <Map s="MOLECULE|Compound type 2" id="43" />
+          <Map s="MOLECULE|Compound type 0" id="40" />
+          <Map s="MOLECULE|Compound type 1" id="41" />
+          <Map s="MOLECULE|Compound type 2" id="42" />
+          <Map s="MOLECULE|base_For_P_cell_Factor" id="43" />
           <Map s="..|pKa_pH_WS_int_K1" id="44" />
           <Map s="..|pKa_pH_WS_int_K2" id="45" />
           <Map s="..|pKa_pH_WS_int_K3" id="46" />
@@ -4519,7 +4519,7 @@
       </FormulaCache>
     </CoreCalculationMethod>
     <CoreCalculationMethod name="Interstitial partition coefficient method - Schmitt" icon="CoreCalculationMethod" bbVersion="0" category="DistributionInterstitial">
-      <Creation createdAt="5248306844190495344" createdBy="EZZJY" creationMode="New" origin="Other" />
+      <Creation createdAt="5248852327098077190" createdBy="Michael" creationMode="New" origin="Other" />
       <OutputFormulas>
         <KeyValue>
           <Formula id="Interstitial partition coefficient method - Schmitt.PARAM_K_int_pls" name="PARAM_K_int_pls" formula="(f_water_int + f_proteins_int_to_pls * (1/fu - f_water_pls)) * fu">
@@ -4541,7 +4541,7 @@
       </OutputFormulas>
       <HelpParameters>
         <KeyValue>
-          <Parameter id="Jf8i5unkpECU4pSTVTaV6A" name="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Interstitial partition coefficient method - Schmitt.PARAM_K_water_int_bon_Schmitt" isDefault="1">
+          <Parameter id="PjucdyVcLUSeVwuSScXV_A" name="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Interstitial partition coefficient method - Schmitt.PARAM_K_water_int_bon_Schmitt" isDefault="1">
             <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
           </Parameter>
           <DescriptorCriteria>
@@ -4551,7 +4551,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="zWEYCspoTk2eWyIWAS8ZVQ" name="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Interstitial partition coefficient method - Schmitt.PARAM_K_water_int_brn_Schmitt" isDefault="1">
+          <Parameter id="IOwM95KDPkierkJVCuIe8A" name="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Interstitial partition coefficient method - Schmitt.PARAM_K_water_int_brn_Schmitt" isDefault="1">
             <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
           </Parameter>
           <DescriptorCriteria>
@@ -4561,7 +4561,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="YtsjP_IqSEOFcQDLaVLimQ" name="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Interstitial partition coefficient method - Schmitt.PARAM_K_water_int_fat_Schmitt" isDefault="1">
+          <Parameter id="2nImZRW9CkWYga6OlRDrVA" name="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Interstitial partition coefficient method - Schmitt.PARAM_K_water_int_fat_Schmitt" isDefault="1">
             <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
           </Parameter>
           <DescriptorCriteria>
@@ -4571,7 +4571,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="qWUSe9pXc0mw98a6-E81aw" name="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Interstitial partition coefficient method - Schmitt.PARAM_K_water_int_hrt_Schmitt" isDefault="1">
+          <Parameter id="n7jz5BlDn0C6uPuFxzdQ8w" name="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Interstitial partition coefficient method - Schmitt.PARAM_K_water_int_hrt_Schmitt" isDefault="1">
             <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
           </Parameter>
           <DescriptorCriteria>
@@ -4581,7 +4581,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="cNCi1-3gc0iJP226F6SHhQ" name="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Interstitial partition coefficient method - Schmitt.PARAM_K_water_int_kid_Schmitt" isDefault="1">
+          <Parameter id="4K0tX-h7h0SXBVpSHPZXgg" name="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Interstitial partition coefficient method - Schmitt.PARAM_K_water_int_kid_Schmitt" isDefault="1">
             <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
           </Parameter>
           <DescriptorCriteria>
@@ -4591,7 +4591,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="lz4pMsMBUkOA-t-DZ0tp8A" name="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Interstitial partition coefficient method - Schmitt.PARAM_K_water_int_lin_Schmitt" isDefault="1">
+          <Parameter id="nEMcvxvwjUezCI_88bJ0Dg" name="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Interstitial partition coefficient method - Schmitt.PARAM_K_water_int_lin_Schmitt" isDefault="1">
             <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
           </Parameter>
           <DescriptorCriteria>
@@ -4602,7 +4602,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="sbbKENwP4Ues22urGeZcWw" name="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Interstitial partition coefficient method - Schmitt.PARAM_K_water_int_liv_Schmitt" isDefault="1">
+          <Parameter id="dhdL4LgGgEOWBqoBXn8DHg" name="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Interstitial partition coefficient method - Schmitt.PARAM_K_water_int_liv_Schmitt" isDefault="1">
             <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
           </Parameter>
           <DescriptorCriteria>
@@ -4612,7 +4612,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="3dEfylvMXEaRJeyl0mcPOw" name="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Interstitial partition coefficient method - Schmitt.PARAM_K_water_int_lng_Schmitt" isDefault="1">
+          <Parameter id="aXAxQiJxyUqLnTrcQ_Xi8w" name="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Interstitial partition coefficient method - Schmitt.PARAM_K_water_int_lng_Schmitt" isDefault="1">
             <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
           </Parameter>
           <DescriptorCriteria>
@@ -4622,7 +4622,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="2Fkm0TySvUijJ5yiLxwhNw" name="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Interstitial partition coefficient method - Schmitt.PARAM_K_water_int_mus_Schmitt" isDefault="1">
+          <Parameter id="UPsw6ZMnxE6MRP9t5Ek5DQ" name="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Interstitial partition coefficient method - Schmitt.PARAM_K_water_int_mus_Schmitt" isDefault="1">
             <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
           </Parameter>
           <DescriptorCriteria>
@@ -4632,7 +4632,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="leQ92_O5R02xl8ucAoqbeA" name="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Interstitial partition coefficient method - Schmitt.PARAM_K_water_int_pan_Schmitt" isDefault="1">
+          <Parameter id="tMG3dw3yzkKZq85-icFjIw" name="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Interstitial partition coefficient method - Schmitt.PARAM_K_water_int_pan_Schmitt" isDefault="1">
             <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
           </Parameter>
           <DescriptorCriteria>
@@ -4642,7 +4642,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="X6tVuzPPmke_qWOyes5t8Q" name="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Interstitial partition coefficient method - Schmitt.PARAM_K_water_int_sin_Schmitt" isDefault="1">
+          <Parameter id="Pade1FKgLk261GJqkXH8MQ" name="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Interstitial partition coefficient method - Schmitt.PARAM_K_water_int_sin_Schmitt" isDefault="1">
             <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
           </Parameter>
           <DescriptorCriteria>
@@ -4653,7 +4653,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="Qfpv3TK9aEmL9SYGPVJIxg" name="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Interstitial partition coefficient method - Schmitt.PARAM_K_water_int_skn_Schmitt" isDefault="1">
+          <Parameter id="cQTeWSBMsUmOBzPQus2kPQ" name="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Interstitial partition coefficient method - Schmitt.PARAM_K_water_int_skn_Schmitt" isDefault="1">
             <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
           </Parameter>
           <DescriptorCriteria>
@@ -4663,7 +4663,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="KczuwGKSA0uOYBIN-6vXyQ" name="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Interstitial partition coefficient method - Schmitt.PARAM_K_water_int_spl_Schmitt" isDefault="1">
+          <Parameter id="Hl72BONhEU-JhM9LXoX3ZQ" name="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Interstitial partition coefficient method - Schmitt.PARAM_K_water_int_spl_Schmitt" isDefault="1">
             <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
           </Parameter>
           <DescriptorCriteria>
@@ -4673,7 +4673,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="1gvP0vWoPk-kRO3eENYaKQ" name="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Interstitial partition coefficient method - Schmitt.PARAM_K_water_int_sto_Schmitt" isDefault="1">
+          <Parameter id="Bqv9ksKOa0u4mgMNVaN91w" name="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Interstitial partition coefficient method - Schmitt.PARAM_K_water_int_sto_Schmitt" isDefault="1">
             <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
           </Parameter>
           <DescriptorCriteria>
@@ -4683,7 +4683,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="RCuEf7ICkE28T4nw5yLHiQ" name="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Interstitial partition coefficient method - Schmitt.PARAM_K_water_int_tes_Schmitt" isDefault="1">
+          <Parameter id="qQumAJY8_0OU2C006ETGBA" name="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Interstitial partition coefficient method - Schmitt.PARAM_K_water_int_tes_Schmitt" isDefault="1">
             <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
           </Parameter>
           <DescriptorCriteria>
@@ -4693,7 +4693,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="PObilNCA7kKpffY1UUbWKg" name="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Interstitial partition coefficient method - Schmitt.PARAM_K_water_prp_Schmitt" isDefault="1">
+          <Parameter id="7PblyRW5ukWA_YpqquDn6A" name="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Interstitial partition coefficient method - Schmitt.PARAM_K_water_prp_Schmitt" isDefault="1">
             <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
           </Parameter>
           <DescriptorCriteria>
@@ -4703,7 +4703,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="3R0Tczt0MU-VgJzInVyi2Q" name="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Interstitial partition coefficient method - Schmitt.PARAM_K_water_prc_Schmitt" isDefault="1">
+          <Parameter id="l81Q81jc7kKgFw70ED8qCw" name="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Interstitial partition coefficient method - Schmitt.PARAM_K_water_prc_Schmitt" isDefault="1">
             <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
           </Parameter>
           <DescriptorCriteria>
@@ -4850,11 +4850,11 @@
       </FormulaCache>
     </CoreCalculationMethod>
     <CoreCalculationMethod name="IntestinalPermeability_PKSim" icon="CoreCalculationMethod" bbVersion="0" category="IntestinalPermeability">
-      <Creation createdAt="5248306844190505345" createdBy="EZZJY" creationMode="New" origin="Other" />
+      <Creation createdAt="5248852327098077190" createdBy="Michael" creationMode="New" origin="Other" />
       <OutputFormulas />
       <HelpParameters>
         <KeyValue>
-          <Parameter id="c0FzOCueVEW7Ky5uiAMB6Q" name="Parameter m for correlation of intestinal permeability (transcellular)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+          <Parameter id="NMGzGVyHVUq2WKErc1joMw" name="Parameter m for correlation of intestinal permeability (transcellular)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
             <Info flag="54" seq="1" ref="0" bb="2" group="75" />
           </Parameter>
           <DescriptorCriteria>
@@ -4864,7 +4864,7 @@
           </DescriptorCriteria>
         </KeyValue>
         <KeyValue>
-          <Parameter id="p06gAiFAFEqH8uYrPiCtOg" name="Parameter b for correlation of intestinal permeability (transcellular)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0">
+          <Parameter id="1WEMIbLA_k6GDvBTBbMGdA" name="Parameter b for correlation of intestinal permeability (transcellular)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0">
             <Info flag="54" seq="1" ref="0" bb="2" group="75" />
           </Parameter>
           <DescriptorCriteria>
diff --git a/src/Data/Templates/2 Pores Passive Transports.pkml b/src/Data/Templates/2 Pores Passive Transports.pkml
index c20b3a2d2..1b6039a82 100644
--- a/src/Data/Templates/2 Pores Passive Transports.pkml	
+++ b/src/Data/Templates/2 Pores Passive Transports.pkml	
@@ -1,8 +1,8 @@
 <?xml version="1.0" encoding="utf-8"?>
-<PassiveTransportBuildingBlock id="FXTRkKlvHkeuT90uhY_FwQ" name="2 Pores Passive Transports" icon="PassiveTransport" bbVersion="0" version="13">
-  <Creation createdAt="5248308555548773716" createdBy="EZZJY" creationMode="New" origin="PKSim" version="7.3.0" internalVersion="74" />
+<PassiveTransportBuildingBlock id="Eft_XOY3hkSyQKCW7uTllA" name="2 Pores Passive Transports" icon="PassiveTransport" bbVersion="0" version="14">
+  <Creation createdAt="5248852327688987798" createdBy="Michael" creationMode="New" origin="PKSim" version="9.0" internalVersion="77" />
   <Builders>
-    <TransportBuilder id="4lr7_fTTSE6HPVzCMn_rJw" name="DrugAbsorption_para" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="1" processRateParameterPersistable="0" formula="WwdRZq6w902F75axG8uU4A" transportType="0">
+    <TransportBuilder id="WeFv8kIqAUCJS3bKbgifJw" name="DrugAbsorption_para" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="1" processRateParameterPersistable="0" formula="2HjX8E_44UuEXLuRYyDu1w" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="Lumen" />
@@ -17,7 +17,7 @@
       </TargetCriteria>
       <MoleculeList forAll="1" />
     </TransportBuilder>
-    <TransportBuilder id="emXDrvpH50GMzFbQ9cmp3Q" name="DrugAbsorption_trans" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="1" processRateParameterPersistable="0" formula="7E3ec7qGikWTLL1xOh9hgA" transportType="0">
+    <TransportBuilder id="EqIEp0qX1EKySkMUKgVHRg" name="DrugAbsorption_trans" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="1" processRateParameterPersistable="0" formula="_PDom0M_i0qyeBa0VRrt0g" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <NotMatchTagCondition tag="Feces" />
@@ -32,7 +32,7 @@
       </TargetCriteria>
       <MoleculeList forAll="1" />
     </TransportBuilder>
-    <TransportBuilder id="p45fJca6eEmUv1p5Pw8sTw" name="EndosomalSpecificClearance_FirstOrder" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="MtiyMMt8B0KXRzgRuNUVxw" transportType="0">
+    <TransportBuilder id="1aO5wvGSUku6IhB5DQQS3A" name="EndosomalSpecificClearance_FirstOrder" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="ThB_M9PPNkaKcjVEU5kWmw" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="Endosome" />
@@ -49,7 +49,7 @@
         </MoleculeNamesToExclude>
       </MoleculeList>
     </TransportBuilder>
-    <TransportBuilder id="yGGtzktg9E6ccTwLjsT9uA" name="IgG_SrcToPlasma" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="FeyK6sEzm0uz3R0s8AGHrQ" transportType="0">
+    <TransportBuilder id="5MdwoeUwN0qZ9QSW34A4Ng" name="IgG_SrcToPlasma" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="YoidPcdo-kKyaLsNsCIPyw" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="Endogenous_IgG" />
@@ -68,7 +68,7 @@
         </MoleculeNames>
       </MoleculeList>
     </TransportBuilder>
-    <TransportBuilder id="GMkX47Ct40a0XSD7P97nxw" name="LumenDrugTransport_cae" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="03o5Ev-iyk67jugfEIHo2g" transportType="0">
+    <TransportBuilder id="N3O6sKssnkmGU4mhD9du6A" name="LumenDrugTransport_cae" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="KyrUY-CfqEu-GzfHCiM0Kw" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="LowerIleum" />
@@ -83,7 +83,7 @@
       </TargetCriteria>
       <MoleculeList forAll="1" />
     </TransportBuilder>
-    <TransportBuilder id="6RSQnHmIFEe8HTSn4wen8g" name="LumenDrugTransport_colasc" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="03o5Ev-iyk67jugfEIHo2g" transportType="0">
+    <TransportBuilder id="rdWt33Kah0SpY5dU3-djXQ" name="LumenDrugTransport_colasc" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="KyrUY-CfqEu-GzfHCiM0Kw" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="Caecum" />
@@ -98,7 +98,7 @@
       </TargetCriteria>
       <MoleculeList forAll="1" />
     </TransportBuilder>
-    <TransportBuilder id="NoXCatSLckWx2jnuvodqPw" name="LumenDrugTransport_coldesc" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="03o5Ev-iyk67jugfEIHo2g" transportType="0">
+    <TransportBuilder id="uaJGAuhahUiB1iLvfS0Eaw" name="LumenDrugTransport_coldesc" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="KyrUY-CfqEu-GzfHCiM0Kw" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="ColonTransversum" />
@@ -113,7 +113,7 @@
       </TargetCriteria>
       <MoleculeList forAll="1" />
     </TransportBuilder>
-    <TransportBuilder id="d8EJoAW2DUWFr2bMmxz7Lg" name="LumenDrugTransport_colsigm" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="03o5Ev-iyk67jugfEIHo2g" transportType="0">
+    <TransportBuilder id="87sQH0gAIUychjQ1bdxeVQ" name="LumenDrugTransport_colsigm" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="KyrUY-CfqEu-GzfHCiM0Kw" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="ColonDescendens" />
@@ -128,7 +128,7 @@
       </TargetCriteria>
       <MoleculeList forAll="1" />
     </TransportBuilder>
-    <TransportBuilder id="_lm2fNwBUkaD2BI7WgjS_g" name="LumenDrugTransport_coltrans" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="03o5Ev-iyk67jugfEIHo2g" transportType="0">
+    <TransportBuilder id="o6n4aYzlvkqHVPi0BvdQVQ" name="LumenDrugTransport_coltrans" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="KyrUY-CfqEu-GzfHCiM0Kw" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="ColonAscendens" />
@@ -143,7 +143,7 @@
       </TargetCriteria>
       <MoleculeList forAll="1" />
     </TransportBuilder>
-    <TransportBuilder id="2Q7A0gN2XUOR68smxd7_hQ" name="LumenDrugTransport_duo" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="03o5Ev-iyk67jugfEIHo2g" transportType="0">
+    <TransportBuilder id="e4JjMyFvxEWoHj8UOFu8qA" name="LumenDrugTransport_duo" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="KyrUY-CfqEu-GzfHCiM0Kw" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="Lumen" />
@@ -158,7 +158,7 @@
       </TargetCriteria>
       <MoleculeList forAll="1" />
     </TransportBuilder>
-    <TransportBuilder id="sUGH4QOiy0Gw2P5TzWCTOw" name="LumenDrugTransport_fec" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="O-XOtCWjDUqvxYfgLFiREA" transportType="0">
+    <TransportBuilder id="PybI4MRkwkO3J5riEZ2Epg" name="LumenDrugTransport_fec" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="VBUqRHaIK0mA2RayZl2a1g" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="Lumen" />
@@ -173,7 +173,7 @@
       </TargetCriteria>
       <MoleculeList forAll="1" />
     </TransportBuilder>
-    <TransportBuilder id="0YeVrqcAWUCsFPx28iibVA" name="LumenDrugTransport_lil" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="03o5Ev-iyk67jugfEIHo2g" transportType="0">
+    <TransportBuilder id="hqd3VO3hFUCEbxqe0XLU5Q" name="LumenDrugTransport_lil" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="KyrUY-CfqEu-GzfHCiM0Kw" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="Lumen" />
@@ -188,7 +188,7 @@
       </TargetCriteria>
       <MoleculeList forAll="1" />
     </TransportBuilder>
-    <TransportBuilder id="2gihLLphRkSVs22KlxG8Aw" name="LumenDrugTransport_lje" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="03o5Ev-iyk67jugfEIHo2g" transportType="0">
+    <TransportBuilder id="7RMB2vcjpkyI3QGeOommfw" name="LumenDrugTransport_lje" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="KyrUY-CfqEu-GzfHCiM0Kw" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="Lumen" />
@@ -203,7 +203,7 @@
       </TargetCriteria>
       <MoleculeList forAll="1" />
     </TransportBuilder>
-    <TransportBuilder id="5hLFiEKZUkqeOtc9kPmAsQ" name="LumenDrugTransport_rect" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="03o5Ev-iyk67jugfEIHo2g" transportType="0">
+    <TransportBuilder id="NBhz7wqAMky3HuHfodjcCQ" name="LumenDrugTransport_rect" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="KyrUY-CfqEu-GzfHCiM0Kw" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="ColonSigmoid" />
@@ -218,7 +218,7 @@
       </TargetCriteria>
       <MoleculeList forAll="1" />
     </TransportBuilder>
-    <TransportBuilder id="MGvy-lXK1kSfLj9pbdaeuA" name="LumenDrugTransport_uil" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="03o5Ev-iyk67jugfEIHo2g" transportType="0">
+    <TransportBuilder id="9gVTY__3SkuCzJSpVoQnEQ" name="LumenDrugTransport_uil" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="KyrUY-CfqEu-GzfHCiM0Kw" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="LowerJejunum" />
@@ -233,7 +233,7 @@
       </TargetCriteria>
       <MoleculeList forAll="1" />
     </TransportBuilder>
-    <TransportBuilder id="OJqxZYouGUuP1Kk7Bn2pnA" name="LumenDrugTransport_uje" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="03o5Ev-iyk67jugfEIHo2g" transportType="0">
+    <TransportBuilder id="hWZbI7F6N0ijFVpPwzKE5w" name="LumenDrugTransport_uje" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="KyrUY-CfqEu-GzfHCiM0Kw" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="Duodenum" />
@@ -248,45 +248,7 @@
       </TargetCriteria>
       <MoleculeList forAll="1" />
     </TransportBuilder>
-    <TransportBuilder id="noTpGnZ14kKO_0IzlQfssA" name="MassTransfer_PeriportalToPericentral_BC" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="saJayb8zB0WIphXLEuqKjQ" transportType="0">
-      <SourceCriteria>
-        <DescriptorConditions>
-          <MatchTagCondition tag="BloodCells" />
-          <MatchTagCondition tag="Liver" />
-          <MatchTagCondition tag="Periportal" />
-        </DescriptorConditions>
-      </SourceCriteria>
-      <TargetCriteria>
-        <DescriptorConditions>
-          <MatchTagCondition tag="BloodCells" />
-          <MatchTagCondition tag="Liver" />
-          <MatchTagCondition tag="Pericentral" />
-        </DescriptorConditions>
-      </TargetCriteria>
-      <MoleculeList forAll="1" />
-    </TransportBuilder>
-    <TransportBuilder id="Dpl3mpiKGUaxkWgl9SiAug" name="MassTransfer_PeriportalToPericentral_Plasma" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="QzRP0wR9w0eUNETMXu3mLw" transportType="0">
-      <SourceCriteria>
-        <DescriptorConditions>
-          <MatchTagCondition tag="Liver" />
-          <MatchTagCondition tag="Periportal" />
-          <MatchTagCondition tag="Plasma" />
-        </DescriptorConditions>
-      </SourceCriteria>
-      <TargetCriteria>
-        <DescriptorConditions>
-          <MatchTagCondition tag="Liver" />
-          <MatchTagCondition tag="Pericentral" />
-          <MatchTagCondition tag="Plasma" />
-        </DescriptorConditions>
-      </TargetCriteria>
-      <MoleculeList forAll="1">
-        <MoleculeNamesToExclude>
-          <MoleculeNamesToExcludeChild>Standard Molecule-FcRn_Complex</MoleculeNamesToExcludeChild>
-        </MoleculeNamesToExclude>
-      </MoleculeList>
-    </TransportBuilder>
-    <TransportBuilder id="ju-VWI48zkysualbEE3rag" name="MassTransferBloodPool2OrgPl" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="Fn19bQWsC0ObAlKkG6Di9A" transportType="0">
+    <TransportBuilder id="smOfkmfzxkS4mA2BcYveVA" name="MassTransferBloodPool2OrgPl" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="SNRt0xRFQkOjO9Ny2jerrw" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="ArterialBlood" />
@@ -307,7 +269,7 @@
         </MoleculeNamesToExclude>
       </MoleculeList>
     </TransportBuilder>
-    <TransportBuilder id="E9XofMVpEEits6wuS8YdLA" name="MassTransferBloodPool2OrgPl_liv" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="OgsQo0qPk029j-vWkZrHfw" transportType="0">
+    <TransportBuilder id="KLRSbP5Gr0iFYpzCyhUUaQ" name="MassTransferBloodPool2OrgPl_liv" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="n2PhyCG5hEeGTKIxJGfRVQ" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="Plasma" />
@@ -327,7 +289,7 @@
         </MoleculeNamesToExclude>
       </MoleculeList>
     </TransportBuilder>
-    <TransportBuilder id="T7vD7xrELUSuWo4W-Fs_YQ" name="MassTransferBloodPool2OrgPl_lng" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="zK2emxmtvkqd1fQza5sheg" transportType="0">
+    <TransportBuilder id="Bfy9pqNRcU6hI3CeoRREfA" name="MassTransferBloodPool2OrgPl_lng" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="pz771YlPHE-5cy6AkC5Ftw" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="Plasma" />
@@ -347,7 +309,7 @@
         </MoleculeNamesToExclude>
       </MoleculeList>
     </TransportBuilder>
-    <TransportBuilder id="-W-2g668g0Wvp94mC-wgPA" name="MassTransferBloodPool2OrgRBC" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="LTp5pG_9aE2SIHRaC0zD-w" transportType="0">
+    <TransportBuilder id="fCi14yAm50SXSnoPHyLp0Q" name="MassTransferBloodPool2OrgRBC" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="tZZznZRLO0-Bu2agAY_sIQ" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="ArterialBlood" />
@@ -363,7 +325,7 @@
       </TargetCriteria>
       <MoleculeList forAll="1" />
     </TransportBuilder>
-    <TransportBuilder id="duRZVrhCsUeE5fsJ9CxVfQ" name="MassTransferBloodPool2OrgRBC_liv" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="v9k1GzQnzk-Bvh9AK1CGFA" transportType="0">
+    <TransportBuilder id="_uFuObcxLEKEhzqtMa8F0A" name="MassTransferBloodPool2OrgRBC_liv" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="j07kiLCuKUyqwwIrC3RAFw" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="BloodCells" />
@@ -378,7 +340,7 @@
       </TargetCriteria>
       <MoleculeList forAll="1" />
     </TransportBuilder>
-    <TransportBuilder id="SjnmF3TPxUm22n6c7wBiiA" name="MassTransferBloodPool2OrgRBC_lng" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="HhL74y7j1USEXoqZwuo3Vg" transportType="0">
+    <TransportBuilder id="kWVirwJ9YkiWV4V2XJ2fMg" name="MassTransferBloodPool2OrgRBC_lng" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="Twwz5ko4BEq-_G6SvaoLFg" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="BloodCells" />
@@ -393,28 +355,7 @@
       </TargetCriteria>
       <MoleculeList forAll="1" />
     </TransportBuilder>
-    <TransportBuilder id="F9_8qtlisEqhnKyEPFWjzg" name="MassTransferLinPlasma2BloodPool_Pve" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="NTB0Uict_E6K8T-6LGM8CA" transportType="0">
-      <SourceCriteria>
-        <DescriptorConditions>
-          <MatchTagCondition tag="LargeIntestine" />
-          <NotMatchTagCondition tag="Mucosa" />
-          <MatchTagCondition tag="Plasma" />
-        </DescriptorConditions>
-      </SourceCriteria>
-      <TargetCriteria>
-        <DescriptorConditions>
-          <MatchTagCondition tag="Plasma" />
-          <MatchTagCondition tag="PortalVein" />
-        </DescriptorConditions>
-      </TargetCriteria>
-      <MoleculeList forAll="1">
-        <MoleculeNamesToExclude>
-          <MoleculeNamesToExcludeChild>FcRn</MoleculeNamesToExcludeChild>
-          <MoleculeNamesToExcludeChild>Standard Molecule-FcRn_Complex</MoleculeNamesToExcludeChild>
-        </MoleculeNamesToExclude>
-      </MoleculeList>
-    </TransportBuilder>
-    <TransportBuilder id="VSJ_NU7JZ02gXOVJacuLjg" name="MassTransferLinRBC2BloodPool_Pve" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="tG9OFSS2pEaG9b3ko7-JTA" transportType="0">
+    <TransportBuilder id="EuQRoD-hWEWQrV4SyS7Y-Q" name="MassTransferLINToMucosaBC" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="k9NkXowGSUW1P_NnDV_yqg" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="BloodCells" />
@@ -425,28 +366,33 @@
       <TargetCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="BloodCells" />
-          <MatchTagCondition tag="PortalVein" />
+          <MatchTagCondition tag="Mucosa" />
         </DescriptorConditions>
       </TargetCriteria>
       <MoleculeList forAll="1" />
     </TransportBuilder>
-    <TransportBuilder id="8ABYlAJOCUq2yL7fE1khww" name="MassTransferLINToMucosaBC" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="6pRxgMapMECPhZOOxTPCPA" transportType="0">
+    <TransportBuilder id="hl7eArsx4UKeR0_HRLgoVQ" name="MassTransferLINToMucosaPlasma" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="4Ed6agH5V0aiL8yts1HnUw" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
-          <MatchTagCondition tag="BloodCells" />
           <MatchTagCondition tag="LargeIntestine" />
           <NotMatchTagCondition tag="Mucosa" />
+          <MatchTagCondition tag="Plasma" />
         </DescriptorConditions>
       </SourceCriteria>
       <TargetCriteria>
         <DescriptorConditions>
-          <MatchTagCondition tag="BloodCells" />
           <MatchTagCondition tag="Mucosa" />
+          <MatchTagCondition tag="Plasma" />
         </DescriptorConditions>
       </TargetCriteria>
-      <MoleculeList forAll="1" />
+      <MoleculeList forAll="1">
+        <MoleculeNamesToExclude>
+          <MoleculeNamesToExcludeChild>FcRn</MoleculeNamesToExcludeChild>
+          <MoleculeNamesToExcludeChild>Standard Molecule-FcRn_Complex</MoleculeNamesToExcludeChild>
+        </MoleculeNamesToExclude>
+      </MoleculeList>
     </TransportBuilder>
-    <TransportBuilder id="YVKeUZSlTE68jxHWtiG_Sg" name="MassTransferLINToMucosaPlasma" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="k1nwLwxSTUSkbq6OfiKbLw" transportType="0">
+    <TransportBuilder id="HT8_omWEIkO8MJCYNOLHSw" name="MassTransferLinPlasma2BloodPool_Pve" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="2qMTsap4R0O2_tB6I4YDGQ" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="LargeIntestine" />
@@ -456,8 +402,8 @@
       </SourceCriteria>
       <TargetCriteria>
         <DescriptorConditions>
-          <MatchTagCondition tag="Mucosa" />
           <MatchTagCondition tag="Plasma" />
+          <MatchTagCondition tag="PortalVein" />
         </DescriptorConditions>
       </TargetCriteria>
       <MoleculeList forAll="1">
@@ -467,7 +413,23 @@
         </MoleculeNamesToExclude>
       </MoleculeList>
     </TransportBuilder>
-    <TransportBuilder id="N1G8LIiXV0iCrf8W-t9-fA" name="MassTransferLymphOrgInt2BloodPool" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="8dYc4IocV0aeuMCY_1vyCw" transportType="0">
+    <TransportBuilder id="v3JHHSVR80Og4s_yN63mRQ" name="MassTransferLinRBC2BloodPool_Pve" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="d73F4zouXU-DaNGWG4QIWA" transportType="0">
+      <SourceCriteria>
+        <DescriptorConditions>
+          <MatchTagCondition tag="BloodCells" />
+          <MatchTagCondition tag="LargeIntestine" />
+          <NotMatchTagCondition tag="Mucosa" />
+        </DescriptorConditions>
+      </SourceCriteria>
+      <TargetCriteria>
+        <DescriptorConditions>
+          <MatchTagCondition tag="BloodCells" />
+          <MatchTagCondition tag="PortalVein" />
+        </DescriptorConditions>
+      </TargetCriteria>
+      <MoleculeList forAll="1" />
+    </TransportBuilder>
+    <TransportBuilder id="s0NW8SNbskyT-MW5yEyBXA" name="MassTransferLymphOrgInt2BloodPool" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="kYHYIQpLNkK9NgD2n6Dt_Q" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="Interstitial" />
@@ -486,7 +448,7 @@
         </MoleculeNamesToExclude>
       </MoleculeList>
     </TransportBuilder>
-    <TransportBuilder id="yOEWU0zOPU-BYeq-e2pCxA" name="MassTransferLymphOrgInt2BloodPool_igg" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="woRgIJH_UE-hw_e-2Czv6A" transportType="0">
+    <TransportBuilder id="tH7Y0df5DEy306EA2AoKkw" name="MassTransferLymphOrgInt2BloodPool_igg" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="MTRt_DRAkE2vZWZcDDXVUw" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="Endogenous_IgG" />
@@ -505,7 +467,7 @@
         </MoleculeNames>
       </MoleculeList>
     </TransportBuilder>
-    <TransportBuilder id="tSSACm6BSEG_YhrEA7WmDg" name="MassTransferMucosaToPveBC" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="CsrbyjF920a4jxFZ55UpBQ" transportType="0">
+    <TransportBuilder id="OQmyNF0Q30SFHcILntXXmQ" name="MassTransferMucosaToPveBC" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="DGE4FQGm_kCRqieBPqttsg" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="BloodCells" />
@@ -520,7 +482,7 @@
       </TargetCriteria>
       <MoleculeList forAll="1" />
     </TransportBuilder>
-    <TransportBuilder id="jkErjfAytEuKe0cPUgECPA" name="MassTransferMucosaToPvePlasma" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="kywlYSCpNkOl9QaYn7elgA" transportType="0">
+    <TransportBuilder id="CKcBeFJWtkqOsAf8z-yILQ" name="MassTransferMucosaToPvePlasma" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="0IDMEOaycUqbQy3q5MHeCw" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="Mucosa" />
@@ -540,7 +502,7 @@
         </MoleculeNamesToExclude>
       </MoleculeList>
     </TransportBuilder>
-    <TransportBuilder id="x2_e3-ZPUkWzfzSOdonwSA" name="MassTransferOrgPl2BloodPool" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="j7QbkXCo4E68SQ6zsr3AJA" transportType="0">
+    <TransportBuilder id="ST2uoTPxwEOpKdkD6gjIAg" name="MassTransferOrgPl2BloodPool" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="sFj2JVB7Lk6y87uO7IZorw" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <NotMatchTagCondition tag="Liver" />
@@ -562,7 +524,7 @@
         </MoleculeNamesToExclude>
       </MoleculeList>
     </TransportBuilder>
-    <TransportBuilder id="ouAokZaqOUCnSlu_FxZg7w" name="MassTransferOrgPl2BloodPool_Liv" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="j8DC7MbzaEi-phJZAl5d3Q" transportType="0">
+    <TransportBuilder id="FTIBj5-0cUigGZ2e1K5BRw" name="MassTransferOrgPl2BloodPool_Liv" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="CMfY_pWUX0eHZ0kg75f8OA" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="Liver" />
@@ -583,7 +545,7 @@
         </MoleculeNamesToExclude>
       </MoleculeList>
     </TransportBuilder>
-    <TransportBuilder id="0y4ZYKybRkKvFvD35tzIWw" name="MassTransferOrgPl2BloodPool_Liv_Pericentral" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="EwnGijvhtUOtfc64kf_2jg" transportType="0">
+    <TransportBuilder id="6VaADS-4yEmB-9PUt4ZRNQ" name="MassTransferOrgPl2BloodPool_Liv_Pericentral" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="ZXKMZe-cEE2nxsFiABKcXA" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="Liver" />
@@ -604,7 +566,7 @@
         </MoleculeNamesToExclude>
       </MoleculeList>
     </TransportBuilder>
-    <TransportBuilder id="lMpPtHbG_0ir7ypnvP6AyA" name="MassTransferOrgPl2BloodPool_Lng" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="sEPA1I3BvUakwIXJhher8A" transportType="0">
+    <TransportBuilder id="MQn30TcqL0amEYFKBNsXAg" name="MassTransferOrgPl2BloodPool_Lng" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="Sbh_FBEMiEWp8ChOYi3zZw" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="Lung" />
@@ -624,7 +586,7 @@
         </MoleculeNamesToExclude>
       </MoleculeList>
     </TransportBuilder>
-    <TransportBuilder id="2VX1JevUC0mc71XKkXVRHQ" name="MassTransferOrgPl2BloodPool_pve" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="hP-7epnSF0qS2UdLDymVqA" transportType="0">
+    <TransportBuilder id="fxotAgpiwkmGR4-jqVzr-g" name="MassTransferOrgPl2BloodPool_pve" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="g2ZCJsw30U-EHZLZP-DQkA" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <NotMatchTagCondition tag="LargeIntestine" />
@@ -647,7 +609,7 @@
         </MoleculeNamesToExclude>
       </MoleculeList>
     </TransportBuilder>
-    <TransportBuilder id="KTh6re3_z0iBtSichuv_Sw" name="MassTransferOrgRBC2BloodPool" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="oM0yaU7dY0uJ6xPkcKFpAg" transportType="0">
+    <TransportBuilder id="6KrM6_ZcUk2YBqyJpSfhFg" name="MassTransferOrgRBC2BloodPool" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="Ik66PRusIk6SpgeBmZy64A" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="BloodCells" />
@@ -664,7 +626,7 @@
       </TargetCriteria>
       <MoleculeList forAll="1" />
     </TransportBuilder>
-    <TransportBuilder id="qkvvsOBYcEOoxbBXmUvy6Q" name="MassTransferOrgRBC2BloodPool_Liv" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="yb7dmIuFQUm1tCMi-6r00g" transportType="0">
+    <TransportBuilder id="Xf8UHCffyEGJL_KGFo6wXw" name="MassTransferOrgRBC2BloodPool_Liv" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="iHLNgjLTP06CeHgJYxr54w" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="BloodCells" />
@@ -680,7 +642,7 @@
       </TargetCriteria>
       <MoleculeList forAll="1" />
     </TransportBuilder>
-    <TransportBuilder id="v6-nnr7Ke0KWH4SYjrEyiw" name="MassTransferOrgRBC2BloodPool_Liv_Pericentral" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="t9shxL8b20ah7YzO-C9UWg" transportType="0">
+    <TransportBuilder id="02dZe0O2oUuvq1hzUfwyTg" name="MassTransferOrgRBC2BloodPool_Liv_Pericentral" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="Gn8c9i5H5kGLeCcuI_Z8AA" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="BloodCells" />
@@ -696,7 +658,7 @@
       </TargetCriteria>
       <MoleculeList forAll="1" />
     </TransportBuilder>
-    <TransportBuilder id="v6v8tkUe-U66h1Luls3ERA" name="MassTransferOrgRBC2BloodPool_Lng" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="kZ1y1zscvkSuC9etZ3HoGg" transportType="0">
+    <TransportBuilder id="OFZMqDgCZUOhYn3jIXQ91w" name="MassTransferOrgRBC2BloodPool_Lng" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="f5TT10gFYEKs02S5O9FhhQ" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="BloodCells" />
@@ -711,7 +673,7 @@
       </TargetCriteria>
       <MoleculeList forAll="1" />
     </TransportBuilder>
-    <TransportBuilder id="our0VAT_-E6z4y2Th7I_ww" name="MassTransferOrgRBC2BloodPool_Pve" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="IoxGtWM200SfrIZzXRFYZA" transportType="0">
+    <TransportBuilder id="0txbrLbGH0m4-X5WzEAZjw" name="MassTransferOrgRBC2BloodPool_Pve" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="7hCZ2-rCK0KQs0QqiVmQRA" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="BloodCells" />
@@ -730,7 +692,44 @@
       </TargetCriteria>
       <MoleculeList forAll="1" />
     </TransportBuilder>
-    <TransportBuilder id="BKK3Abpgi0Oc1BeaW-PyXg" name="MassTransferSinPlasma2BloodPool_Pve" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="NTB0Uict_E6K8T-6LGM8CA" transportType="0">
+    <TransportBuilder id="MMQqWIvLqE6quKZ4lVCDog" name="MassTransferSINToMucosaBC" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="k9NkXowGSUW1P_NnDV_yqg" transportType="0">
+      <SourceCriteria>
+        <DescriptorConditions>
+          <MatchTagCondition tag="BloodCells" />
+          <NotMatchTagCondition tag="Mucosa" />
+          <MatchTagCondition tag="SmallIntestine" />
+        </DescriptorConditions>
+      </SourceCriteria>
+      <TargetCriteria>
+        <DescriptorConditions>
+          <MatchTagCondition tag="BloodCells" />
+          <MatchTagCondition tag="Mucosa" />
+        </DescriptorConditions>
+      </TargetCriteria>
+      <MoleculeList forAll="1" />
+    </TransportBuilder>
+    <TransportBuilder id="CdCLPiu8kE-U8iaJkKpXwA" name="MassTransferSINToMucosaPlasma" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="4Ed6agH5V0aiL8yts1HnUw" transportType="0">
+      <SourceCriteria>
+        <DescriptorConditions>
+          <NotMatchTagCondition tag="Mucosa" />
+          <MatchTagCondition tag="Plasma" />
+          <MatchTagCondition tag="SmallIntestine" />
+        </DescriptorConditions>
+      </SourceCriteria>
+      <TargetCriteria>
+        <DescriptorConditions>
+          <MatchTagCondition tag="Mucosa" />
+          <MatchTagCondition tag="Plasma" />
+        </DescriptorConditions>
+      </TargetCriteria>
+      <MoleculeList forAll="1">
+        <MoleculeNamesToExclude>
+          <MoleculeNamesToExcludeChild>FcRn</MoleculeNamesToExcludeChild>
+          <MoleculeNamesToExcludeChild>Standard Molecule-FcRn_Complex</MoleculeNamesToExcludeChild>
+        </MoleculeNamesToExclude>
+      </MoleculeList>
+    </TransportBuilder>
+    <TransportBuilder id="F6cSkN3Tx0GjZz9QYDjVbw" name="MassTransferSinPlasma2BloodPool_Pve" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="2qMTsap4R0O2_tB6I4YDGQ" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <NotMatchTagCondition tag="Mucosa" />
@@ -751,7 +750,7 @@
         </MoleculeNamesToExclude>
       </MoleculeList>
     </TransportBuilder>
-    <TransportBuilder id="0-SyF6c6KE6UJSZ946Wz4Q" name="MassTransferSinRBC2BloodPool_Pve" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="tG9OFSS2pEaG9b3ko7-JTA" transportType="0">
+    <TransportBuilder id="jYchIfnmFUKRDtI7yDfFVw" name="MassTransferSinRBC2BloodPool_Pve" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="d73F4zouXU-DaNGWG4QIWA" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="BloodCells" />
@@ -767,44 +766,45 @@
       </TargetCriteria>
       <MoleculeList forAll="1" />
     </TransportBuilder>
-    <TransportBuilder id="xduxvrm9KUi5qAj2z_n_Iw" name="MassTransferSINToMucosaBC" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="6pRxgMapMECPhZOOxTPCPA" transportType="0">
+    <TransportBuilder id="I9siZ9Ttwku9ZuoEAyDyQg" name="MassTransfer_PeriportalToPericentral_BC" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="kaWZ68yLyEmmEupureer3Q" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="BloodCells" />
-          <NotMatchTagCondition tag="Mucosa" />
-          <MatchTagCondition tag="SmallIntestine" />
+          <MatchTagCondition tag="Liver" />
+          <MatchTagCondition tag="Periportal" />
         </DescriptorConditions>
       </SourceCriteria>
       <TargetCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="BloodCells" />
-          <MatchTagCondition tag="Mucosa" />
+          <MatchTagCondition tag="Liver" />
+          <MatchTagCondition tag="Pericentral" />
         </DescriptorConditions>
       </TargetCriteria>
       <MoleculeList forAll="1" />
     </TransportBuilder>
-    <TransportBuilder id="bGxguwJiFECmAqaAF_W1Nw" name="MassTransferSINToMucosaPlasma" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="k1nwLwxSTUSkbq6OfiKbLw" transportType="0">
+    <TransportBuilder id="Kilpa4v6DEe8tRKoQicUoA" name="MassTransfer_PeriportalToPericentral_Plasma" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="StAVFVrYgE6fLQGS2Mr9hw" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
-          <NotMatchTagCondition tag="Mucosa" />
+          <MatchTagCondition tag="Liver" />
+          <MatchTagCondition tag="Periportal" />
           <MatchTagCondition tag="Plasma" />
-          <MatchTagCondition tag="SmallIntestine" />
         </DescriptorConditions>
       </SourceCriteria>
       <TargetCriteria>
         <DescriptorConditions>
-          <MatchTagCondition tag="Mucosa" />
+          <MatchTagCondition tag="Liver" />
+          <MatchTagCondition tag="Pericentral" />
           <MatchTagCondition tag="Plasma" />
         </DescriptorConditions>
       </TargetCriteria>
       <MoleculeList forAll="1">
         <MoleculeNamesToExclude>
-          <MoleculeNamesToExcludeChild>FcRn</MoleculeNamesToExcludeChild>
           <MoleculeNamesToExcludeChild>Standard Molecule-FcRn_Complex</MoleculeNamesToExcludeChild>
         </MoleculeNamesToExclude>
       </MoleculeList>
     </TransportBuilder>
-    <TransportBuilder id="3dafdRYFM0298vOAImcvKA" name="NetMassTransfer_EndosomalToInterstitial_FcRn_Complex" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="EHNWFBo-AUa0fuaQhro8Mg" transportType="0">
+    <TransportBuilder id="eRZ4_OVLQk6VtwVjrkl4Bg" name="NetMassTransfer_EndosomalToInterstitial_FcRn_Complex" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="H30Otgu3Kk6TZFbJSu0qJA" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="Endosome" />
@@ -822,7 +822,7 @@
         </MoleculeNames>
       </MoleculeList>
     </TransportBuilder>
-    <TransportBuilder id="f7wmi7gVm0-Te3FLtIxi1Q" name="NetMassTransfer_EndosomalToPlasma_FcRn_Complex" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="iGfN-2HZFUiUAnE3FQjL7Q" transportType="0">
+    <TransportBuilder id="dOsiz6Z2cE2vtcifb9irKg" name="NetMassTransfer_EndosomalToPlasma_FcRn_Complex" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="k_2EHMU2L0CHR9icDxbgmg" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="Endosome" />
@@ -840,7 +840,7 @@
         </MoleculeNames>
       </MoleculeList>
     </TransportBuilder>
-    <TransportBuilder id="a2A1MLiz4US6F4dixRaf3Q" name="NetMassTransfer_InterstitialToEndosomal" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="dKsGGleux0e_RwDOFnhM0w" transportType="0">
+    <TransportBuilder id="jlOobVTpf0KQUU6LpF1cBQ" name="NetMassTransfer_InterstitialToEndosomal" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="tOHxG7eX9E6L8ihNtrvcpA" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <NotMatchTagCondition tag="EndogenousIgG" />
@@ -861,7 +861,7 @@
         </MoleculeNamesToExclude>
       </MoleculeList>
     </TransportBuilder>
-    <TransportBuilder id="ZXrSVm96qUS2UDZ9Vz-gnA" name="NetMassTransfer_InterstitialToEndosomal_FcRn" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="2thqorGNn0alJ-QfrsQ8dA" transportType="0">
+    <TransportBuilder id="ePHzh6Jnp0uT3I8S7VqGQg" name="NetMassTransfer_InterstitialToEndosomal_FcRn" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="9AgfFZ95rU-N9_p_c9kB4A" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="Endogenous_IgG" />
@@ -880,7 +880,7 @@
         </MoleculeNames>
       </MoleculeList>
     </TransportBuilder>
-    <TransportBuilder id="ISnbe0dwt0KpJZDK65hvrA" name="NetMassTransfer_InterstitialToEndosomal_LigandEndo" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="AwtHpmg61k23OqJxYqcr4g" transportType="0">
+    <TransportBuilder id="_Wqbnw0P6EWvbBbnzrQSXA" name="NetMassTransfer_InterstitialToEndosomal_LigandEndo" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="-knrI4Lq5UKSGx8DZPm0RA" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="Endogenous_IgG" />
@@ -899,7 +899,7 @@
         </MoleculeNames>
       </MoleculeList>
     </TransportBuilder>
-    <TransportBuilder id="1SH__uDjokitSVNFcFMilg" name="NetMassTransfer_PlasmaToEndosomal" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="HJnRovduM0Gx3ZFKRkripA" transportType="0">
+    <TransportBuilder id="HaRjwtf_AkqXgSs1DlyGgA" name="NetMassTransfer_PlasmaToEndosomal" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="7fdT_3PPM0GWQXuRWNpE-A" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <NotMatchTagCondition tag="EndogenousIgG" />
@@ -920,7 +920,7 @@
         </MoleculeNamesToExclude>
       </MoleculeList>
     </TransportBuilder>
-    <TransportBuilder id="gqp5Ekf8jkal15nq6IEyzA" name="NetMassTransfer_PlasmaToEndosomal_FcRn" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="pRDqVCPgkEKwX3dCKb1Zng" transportType="0">
+    <TransportBuilder id="rsK8Mve9_US3iQr955WXmQ" name="NetMassTransfer_PlasmaToEndosomal_FcRn" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="bC1tPzgJ90GHF8Kr89aGbw" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="Endogenous_IgG" />
@@ -939,7 +939,7 @@
         </MoleculeNames>
       </MoleculeList>
     </TransportBuilder>
-    <TransportBuilder id="xbjHL9fAgEegAu0IiBuwhg" name="NetMassTransfer_PlasmaToEndosomal_LigandEndo" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="2I1wunPZN0ur-e5CaC4GJw" transportType="0">
+    <TransportBuilder id="BEpPHrkVKEui_e8lqgo10A" name="NetMassTransfer_PlasmaToEndosomal_LigandEndo" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="UUmz55RSFEe_BDOt-l0mvA" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="Endogenous_IgG" />
@@ -958,7 +958,7 @@
         </MoleculeNames>
       </MoleculeList>
     </TransportBuilder>
-    <TransportBuilder id="08wB-X8-YkW9pZdvZFcABw" name="PassiveDiffusionInt2Cell" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="N1PcG8LEakSXa229OrHLwg" transportType="0">
+    <TransportBuilder id="qxSyv6JfK0yR45mqprC_RQ" name="PassiveDiffusionInt2Cell" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="6et2C619oECa6yQvCD6UlQ" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="Interstitial" />
@@ -976,7 +976,7 @@
         </MoleculeNamesToExclude>
       </MoleculeList>
     </TransportBuilder>
-    <TransportBuilder id="jXFt6uL3HU-9uz_HSWnZgw" name="PassiveDiffusionPl2Int" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="gaeuJWqVJESJGx0-czs_VQ" transportType="0">
+    <TransportBuilder id="LSGn5thdp0edYk3GhnR6kw" name="PassiveDiffusionPl2Int" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="CuwFkiPRBU-iTCDknL1L5g" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <NotMatchTagCondition tag="ArterialBlood" />
@@ -1000,7 +1000,7 @@
         </MoleculeNamesToExclude>
       </MoleculeList>
     </TransportBuilder>
-    <TransportBuilder id="RB2p3u0soUOyFt72H9WHpw" name="PassiveDiffusionPl2RBC" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="hUoty0fZUEmbNXblsAJCEA" transportType="0">
+    <TransportBuilder id="mwESfB9Gjk6O11S3isg8BA" name="PassiveDiffusionPl2RBC" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="o07RWWggjEyk0-rCdyS1Hw" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="Plasma" />
@@ -1018,7 +1018,7 @@
         </MoleculeNamesToExclude>
       </MoleculeList>
     </TransportBuilder>
-    <TransportBuilder id="v2gWwPKrQkGQY5blm8I4lA" name="PassiveDiffusionPlsToSaliva" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="a2zuIDMdHU6WuGwi-4LG1A" transportType="0">
+    <TransportBuilder id="MRfTvmZ_8kKgmvloPMEQxA" name="PassiveDiffusionPlsToSaliva" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="TwFF8l2dIUehLOHlLMW2tA" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="Saliva" />
@@ -1033,7 +1033,7 @@
       </TargetCriteria>
       <MoleculeList forAll="1" />
     </TransportBuilder>
-    <TransportBuilder id="pqq45kHw20SksYTXRUJgYw" name="TwoPoresTransportLink" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="dvoepzPjOUatNp_hrvsH2A" transportType="0">
+    <TransportBuilder id="WfCseH4T7Uuw6NCHnsB4Gg" name="TwoPoresTransportLink" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="Nvii8q8x40-8UjiYe-MSxg" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <NotMatchTagCondition tag="ArterialBlood" />
@@ -1057,7 +1057,7 @@
         </MoleculeNamesToExclude>
       </MoleculeList>
     </TransportBuilder>
-    <TransportBuilder id="FpBD2lXjeUCGl7QUmYJ5Wg" name="TwoPoresTransportLink_igg" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="FXpV8OYX6Uu7anrG9f8kkA" transportType="0">
+    <TransportBuilder id="sdlLSKfuZka39h1TDs-spQ" name="TwoPoresTransportLink_igg" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="AKfeCsyEZkWByVzs37q-Rg" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="Endogenous_IgG" />
@@ -1077,7 +1077,7 @@
         </MoleculeNamesToExclude>
       </MoleculeList>
     </TransportBuilder>
-    <TransportBuilder id="TcEgIX4YdEi7Y6fOtQr89A" name="GallbladderEmptying" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="8L9SRwGqxkO0Cfj-1vHCzA" transportType="0">
+    <TransportBuilder id="Pu-ibSDESEmf_U0dC1kL_w" name="GallbladderEmptying" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="QcAxpJ5rGUiiG1Px0HWEbw" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="Gallbladder" />
@@ -1094,29 +1094,29 @@
   </Builders>
   <FormulaCache>
     <Formulas>
-      <Formula id="WwdRZq6w902F75axG8uU4A" name="DrugAbsorption_para" dim="Amount per time" formula="DrugAbsorptionLumenToMucosaRate">
+      <Formula id="2HjX8E_44UuEXLuRYyDu1w" name="DrugAbsorption_para" dim="Amount per time" formula="DrugAbsorptionLumenToMucosaRate">
         <Paths>
           <Path path="0" as="1" dim="2" />
         </Paths>
       </Formula>
-      <Formula id="7E3ec7qGikWTLL1xOh9hgA" name="DrugAbsorption_trans" dim="Amount per time" formula="DrugAbsorptionLumenToMucosaRate">
+      <Formula id="_PDom0M_i0qyeBa0VRrt0g" name="DrugAbsorption_trans" dim="Amount per time" formula="DrugAbsorptionLumenToMucosaRate">
         <Paths>
           <Path path="0" as="1" dim="2" />
         </Paths>
       </Formula>
-      <Formula id="MtiyMMt8B0KXRzgRuNUVxw" name="EndosomaleSpecificClearance" dim="Amount per time" formula="CLspec*C_end*V_end">
+      <Formula id="ThB_M9PPNkaKcjVEU5kWmw" name="EndosomaleSpecificClearance" dim="Amount per time" formula="CLspec*C_end*V_end">
         <Paths>
           <Path path="3" as="4" dim="5" />
           <Path path="6" as="7" dim="8" />
           <Path path="9" as="10" dim="11" />
         </Paths>
       </Formula>
-      <Formula id="FeyK6sEzm0uz3R0s8AGHrQ" name="IgG_SrcToPlasma" dim="Amount per time" formula="IgG_kin">
+      <Formula id="YoidPcdo-kKyaLsNsCIPyw" name="IgG_SrcToPlasma" dim="Amount per time" formula="IgG_kin">
         <Paths>
           <Path path="12" as="13" dim="2" />
         </Paths>
       </Formula>
-      <Formula id="03o5Ev-iyk67jugfEIHo2g" name="LumenDrugTransport" dim="Amount per time" formula="(OralApplicationsEnabled AND IsFloatingInLumen) ? w*Drug*FillLevelFlagNext : 0">
+      <Formula id="KyrUY-CfqEu-GzfHCiM0Kw" name="LumenDrugTransport" dim="Amount per time" formula="(OralApplicationsEnabled AND IsFloatingInLumen) ? w*Drug*FillLevelFlagNext : 0">
         <Paths>
           <Path path="14" as="15" />
           <Path path="16" as="17" dim="18" />
@@ -1125,212 +1125,212 @@
           <Path path="23" as="24" />
         </Paths>
       </Formula>
-      <Formula id="O-XOtCWjDUqvxYfgLFiREA" name="LumenDrugTransport_Feces" dim="Amount per time" formula="OralApplicationsEnabled ? w*Drug : 0">
+      <Formula id="VBUqRHaIK0mA2RayZl2a1g" name="LumenDrugTransport_Feces" dim="Amount per time" formula="OralApplicationsEnabled ? w*Drug : 0">
         <Paths>
           <Path path="14" as="15" />
           <Path path="16" as="17" dim="18" />
           <Path path="21" as="22" dim="11" />
         </Paths>
       </Formula>
-      <Formula id="saJayb8zB0WIphXLEuqKjQ" name="MassTransferPeriportal2PericentralBC_liv" dim="Amount per time" formula="IsLiverZonated ? (Q_liv +Q_pve)*HCT*C_bc : 0">
+      <Formula id="SNRt0xRFQkOjO9Ny2jerrw" name="MassTransferBloodPool2OrgPl" dim="Amount per time" formula="Q*(1-HCT)*C_pls">
         <Paths>
           <Path path="25" as="26" dim="27" />
           <Path path="3" as="28" dim="5" />
-          <Path path="29" as="30" dim="27" />
-          <Path path="31" as="32" />
-          <Path path="33" as="34" />
+          <Path path="29" as="30" />
         </Paths>
       </Formula>
-      <Formula id="QzRP0wR9w0eUNETMXu3mLw" name="MassTransferPeriportal2PericentralPl_liv" dim="Amount per time" formula="IsLiverZonated ? ((Q_liv +Q_pve)*(1-HCT)-Q_lymph_periportal-Q_lymph_pve)*C_pls : 0">
+      <Formula id="n2PhyCG5hEeGTKIxJGfRVQ" name="MassTransferBloodPool2OrgPl_liv" dim="Amount per time" formula="(Q*(1-HCT)-Q_lymph)*C_pls">
         <Paths>
-          <Path path="25" as="26" dim="27" />
-          <Path path="3" as="35" dim="5" />
-          <Path path="29" as="30" dim="27" />
-          <Path path="31" as="32" />
-          <Path path="33" as="34" />
-          <Path path="36" as="37" dim="27" />
-          <Path path="38" as="39" dim="27" />
+          <Path path="31" as="26" dim="27" />
+          <Path path="32" as="33" dim="27" />
+          <Path path="3" as="28" dim="5" />
+          <Path path="29" as="30" />
         </Paths>
       </Formula>
-      <Formula id="Fn19bQWsC0ObAlKkG6Di9A" name="MassTransferBloodPool2OrgPl" dim="Amount per time" formula="Q*(1-HCT)*C_pls">
+      <Formula id="pz771YlPHE-5cy6AkC5Ftw" name="MassTransferBloodPool2OrgPl_lng" dim="Amount per time" formula="(Q*(1-HCT)+Q_lymph)*C_pls">
         <Paths>
-          <Path path="40" as="41" dim="27" />
-          <Path path="3" as="35" dim="5" />
-          <Path path="31" as="32" />
+          <Path path="25" as="26" dim="27" />
+          <Path path="34" as="33" dim="27" />
+          <Path path="3" as="28" dim="5" />
+          <Path path="29" as="30" />
         </Paths>
       </Formula>
-      <Formula id="OgsQo0qPk029j-vWkZrHfw" name="MassTransferBloodPool2OrgPl_liv" dim="Amount per time" formula="(Q*(1-HCT)-Q_lymph)*C_pls">
+      <Formula id="tZZznZRLO0-Bu2agAY_sIQ" name="MassTransferBloodPool2OrgRBC" dim="Amount per time" formula="Q*HCT*C_bc">
         <Paths>
-          <Path path="25" as="41" dim="27" />
-          <Path path="42" as="43" dim="27" />
+          <Path path="25" as="26" dim="27" />
           <Path path="3" as="35" dim="5" />
-          <Path path="31" as="32" />
+          <Path path="29" as="30" />
         </Paths>
       </Formula>
-      <Formula id="zK2emxmtvkqd1fQza5sheg" name="MassTransferBloodPool2OrgPl_lng" dim="Amount per time" formula="(Q*(1-HCT)+Q_lymph)*C_pls">
+      <Formula id="j07kiLCuKUyqwwIrC3RAFw" name="MassTransferBloodPool2OrgRBC_liv" dim="Amount per time" formula="Q*HCT*C_bc">
         <Paths>
-          <Path path="40" as="41" dim="27" />
-          <Path path="44" as="43" dim="27" />
+          <Path path="31" as="26" dim="27" />
           <Path path="3" as="35" dim="5" />
-          <Path path="31" as="32" />
+          <Path path="29" as="30" />
         </Paths>
       </Formula>
-      <Formula id="LTp5pG_9aE2SIHRaC0zD-w" name="MassTransferBloodPool2OrgRBC" dim="Amount per time" formula="Q*HCT*C_bc">
+      <Formula id="Twwz5ko4BEq-_G6SvaoLFg" name="MassTransferBloodPool2OrgRBC_lng" dim="Amount per time" formula="Q*HCT*C_bc">
         <Paths>
-          <Path path="40" as="41" dim="27" />
-          <Path path="3" as="28" dim="5" />
-          <Path path="31" as="32" />
+          <Path path="25" as="26" dim="27" />
+          <Path path="3" as="35" dim="5" />
+          <Path path="29" as="30" />
         </Paths>
       </Formula>
-      <Formula id="v9k1GzQnzk-Bvh9AK1CGFA" name="MassTransferBloodPool2OrgRBC_liv" dim="Amount per time" formula="Q*HCT*C_bc">
+      <Formula id="k9NkXowGSUW1P_NnDV_yqg" name="MassTransferIntestineToMucosaBC" dim="Amount per time" formula="MassTransferIntestineToMucosaBCRate">
         <Paths>
-          <Path path="25" as="41" dim="27" />
-          <Path path="3" as="28" dim="5" />
-          <Path path="31" as="32" />
+          <Path path="36" as="37" dim="2" />
         </Paths>
       </Formula>
-      <Formula id="HhL74y7j1USEXoqZwuo3Vg" name="MassTransferBloodPool2OrgRBC_lng" dim="Amount per time" formula="Q*HCT*C_bc">
+      <Formula id="4Ed6agH5V0aiL8yts1HnUw" name="MassTransferIntestineToMucosaPlasma" dim="Amount per time" formula="MassTransferIntestineToMucosaPlasmaRate">
         <Paths>
-          <Path path="40" as="41" dim="27" />
-          <Path path="3" as="28" dim="5" />
-          <Path path="31" as="32" />
+          <Path path="38" as="39" dim="2" />
         </Paths>
       </Formula>
-      <Formula id="NTB0Uict_E6K8T-6LGM8CA" name="MassTransferSinLinPlasma2BloodPool_Pve" dim="Amount per time" formula="((1-fractQ)*Q*(1-HCT)-Q_lymph)*C">
+      <Formula id="2qMTsap4R0O2_tB6I4YDGQ" name="MassTransferSinLinPlasma2BloodPool_Pve" dim="Amount per time" formula="((1-fractQ)*Q*(1-HCT)-Q_lymph)*C">
         <Paths>
-          <Path path="25" as="41" dim="27" />
-          <Path path="42" as="43" dim="27" />
-          <Path path="45" as="46" />
-          <Path path="3" as="47" dim="5" />
-          <Path path="31" as="32" />
+          <Path path="31" as="26" dim="27" />
+          <Path path="32" as="33" dim="27" />
+          <Path path="40" as="41" />
+          <Path path="3" as="42" dim="5" />
+          <Path path="29" as="30" />
         </Paths>
       </Formula>
-      <Formula id="tG9OFSS2pEaG9b3ko7-JTA" name="MassTransferSinLinRBC2BloodPool_Pve" dim="Amount per time" formula="(1-fractQ)*Q*HCT*C">
+      <Formula id="d73F4zouXU-DaNGWG4QIWA" name="MassTransferSinLinRBC2BloodPool_Pve" dim="Amount per time" formula="(1-fractQ)*Q*HCT*C">
         <Paths>
-          <Path path="25" as="41" dim="27" />
-          <Path path="45" as="46" />
-          <Path path="3" as="47" dim="5" />
-          <Path path="31" as="32" />
+          <Path path="31" as="26" dim="27" />
+          <Path path="40" as="41" />
+          <Path path="3" as="42" dim="5" />
+          <Path path="29" as="30" />
         </Paths>
       </Formula>
-      <Formula id="6pRxgMapMECPhZOOxTPCPA" name="MassTransferIntestineToMucosaBC" dim="Amount per time" formula="MassTransferIntestineToMucosaBCRate">
+      <Formula id="kYHYIQpLNkK9NgD2n6Dt_Q" name="MassTransferLymphOrgInt2BloodPool" dim="Amount per time" formula="Q_lymph*C_int">
         <Paths>
-          <Path path="48" as="49" dim="2" />
+          <Path path="32" as="33" dim="27" />
+          <Path path="3" as="43" dim="5" />
         </Paths>
       </Formula>
-      <Formula id="k1nwLwxSTUSkbq6OfiKbLw" name="MassTransferIntestineToMucosaPlasma" dim="Amount per time" formula="MassTransferIntestineToMucosaPlasmaRate">
+      <Formula id="MTRt_DRAkE2vZWZcDDXVUw" name="MassTransferLymphOrgInt2BloodPool_igg" dim="Amount per time" formula="Q_lymph*C_int">
         <Paths>
-          <Path path="50" as="51" dim="2" />
+          <Path path="32" as="33" dim="27" />
+          <Path path="3" as="43" dim="5" />
         </Paths>
       </Formula>
-      <Formula id="8dYc4IocV0aeuMCY_1vyCw" name="MassTransferLymphOrgInt2BloodPool" dim="Amount per time" formula="Q_lymph*C_int">
+      <Formula id="DGE4FQGm_kCRqieBPqttsg" name="MassTransferMucosaToPveBC" dim="Amount per time" formula="MassTransferMucosaToPveBCRate">
         <Paths>
-          <Path path="42" as="43" dim="27" />
-          <Path path="3" as="52" dim="5" />
+          <Path path="44" as="45" dim="2" />
         </Paths>
       </Formula>
-      <Formula id="woRgIJH_UE-hw_e-2Czv6A" name="MassTransferLymphOrgInt2BloodPool_igg" dim="Amount per time" formula="Q_lymph*C_int">
+      <Formula id="0IDMEOaycUqbQy3q5MHeCw" name="MassTransferMucosaToPvePlasma" dim="Amount per time" formula="MassTransferMucosaToPvePlasmaRate">
         <Paths>
-          <Path path="42" as="43" dim="27" />
-          <Path path="3" as="52" dim="5" />
+          <Path path="46" as="47" dim="2" />
         </Paths>
       </Formula>
-      <Formula id="CsrbyjF920a4jxFZ55UpBQ" name="MassTransferMucosaToPveBC" dim="Amount per time" formula="MassTransferMucosaToPveBCRate">
+      <Formula id="sFj2JVB7Lk6y87uO7IZorw" name="MassTransferOrgPl2BloodPool" dim="Amount per time" formula="(Q*(1-HCT)-Q_lymph)*C_pls">
         <Paths>
-          <Path path="53" as="54" dim="2" />
+          <Path path="31" as="26" dim="27" />
+          <Path path="32" as="33" dim="27" />
+          <Path path="3" as="28" dim="5" />
+          <Path path="29" as="30" />
         </Paths>
       </Formula>
-      <Formula id="kywlYSCpNkOl9QaYn7elgA" name="MassTransferMucosaToPvePlasma" dim="Amount per time" formula="MassTransferMucosaToPvePlasmaRate">
+      <Formula id="CMfY_pWUX0eHZ0kg75f8OA" name="MassTransferOrgPl2BloodPool_Liv" dim="Amount per time" formula="IsLiverZonated ? 0 : ((Q_liv+Q_pve)*(1-HCT)-Q_lymph_periportal-Q_lymph_pve)*C_pls">
         <Paths>
-          <Path path="55" as="56" dim="2" />
+          <Path path="31" as="48" dim="27" />
+          <Path path="3" as="28" dim="5" />
+          <Path path="29" as="30" />
+          <Path path="49" as="50" />
+          <Path path="51" as="52" dim="27" />
+          <Path path="53" as="54" dim="27" />
+          <Path path="55" as="56" dim="27" />
         </Paths>
       </Formula>
-      <Formula id="j7QbkXCo4E68SQ6zsr3AJA" name="MassTransferOrgPl2BloodPool" dim="Amount per time" formula="(Q*(1-HCT)-Q_lymph)*C_pls">
+      <Formula id="ZXKMZe-cEE2nxsFiABKcXA" name="MassTransferOrgPl2BloodPool_Liv_Pericentral" dim="Amount per time" formula="IsLiverZonated ? ((Q_liv+Q_pve)*(1-HCT)-Q_lymph_periportal-Q_lymph_pericentral-Q_lymph_pve)*C_pls : 0">
         <Paths>
-          <Path path="25" as="41" dim="27" />
-          <Path path="42" as="43" dim="27" />
-          <Path path="3" as="35" dim="5" />
-          <Path path="31" as="32" />
+          <Path path="31" as="48" dim="27" />
+          <Path path="3" as="28" dim="5" />
+          <Path path="29" as="30" />
+          <Path path="49" as="50" />
+          <Path path="51" as="52" dim="27" />
+          <Path path="53" as="54" dim="27" />
+          <Path path="55" as="56" dim="27" />
+          <Path path="57" as="58" dim="27" />
         </Paths>
       </Formula>
-      <Formula id="j8DC7MbzaEi-phJZAl5d3Q" name="MassTransferOrgPl2BloodPool_Liv" dim="Amount per time" formula="IsLiverZonated ? 0 : ((Q_liv+Q_pve)*(1-HCT)-Q_lymph_periportal-Q_lymph_pve)*C_pls">
+      <Formula id="Sbh_FBEMiEWp8ChOYi3zZw" name="MassTransferOrgPl2BloodPool_Lng" dim="Amount per time" formula="Q*(1-HCT)*C_pls">
         <Paths>
-          <Path path="25" as="26" dim="27" />
-          <Path path="3" as="35" dim="5" />
-          <Path path="31" as="32" />
-          <Path path="33" as="34" />
-          <Path path="29" as="30" dim="27" />
-          <Path path="36" as="37" dim="27" />
-          <Path path="38" as="39" dim="27" />
+          <Path path="31" as="26" dim="27" />
+          <Path path="3" as="28" dim="5" />
+          <Path path="29" as="30" />
         </Paths>
       </Formula>
-      <Formula id="EwnGijvhtUOtfc64kf_2jg" name="MassTransferOrgPl2BloodPool_Liv_Pericentral" dim="Amount per time" formula="IsLiverZonated ? ((Q_liv+Q_pve)*(1-HCT)-Q_lymph_periportal-Q_lymph_pericentral-Q_lymph_pve)*C_pls : 0">
+      <Formula id="g2ZCJsw30U-EHZLZP-DQkA" name="MassTransferOrgPl2BloodPool_pve" dim="Amount per time" formula="(Q*(1-HCT)-Q_lymph)*C_pls">
         <Paths>
-          <Path path="25" as="26" dim="27" />
-          <Path path="3" as="35" dim="5" />
-          <Path path="31" as="32" />
-          <Path path="33" as="34" />
-          <Path path="29" as="30" dim="27" />
-          <Path path="36" as="37" dim="27" />
-          <Path path="38" as="39" dim="27" />
-          <Path path="57" as="58" dim="27" />
+          <Path path="31" as="26" dim="27" />
+          <Path path="32" as="33" dim="27" />
+          <Path path="3" as="28" dim="5" />
+          <Path path="29" as="30" />
         </Paths>
       </Formula>
-      <Formula id="sEPA1I3BvUakwIXJhher8A" name="MassTransferOrgPl2BloodPool_Lng" dim="Amount per time" formula="Q*(1-HCT)*C_pls">
+      <Formula id="Ik66PRusIk6SpgeBmZy64A" name="MassTransferOrgRBC2BloodPool" dim="Amount per time" formula="Q*HCT*C_bc">
         <Paths>
-          <Path path="25" as="41" dim="27" />
+          <Path path="31" as="26" dim="27" />
           <Path path="3" as="35" dim="5" />
-          <Path path="31" as="32" />
+          <Path path="29" as="30" />
         </Paths>
       </Formula>
-      <Formula id="hP-7epnSF0qS2UdLDymVqA" name="MassTransferOrgPl2BloodPool_pve" dim="Amount per time" formula="(Q*(1-HCT)-Q_lymph)*C_pls">
+      <Formula id="iHLNgjLTP06CeHgJYxr54w" name="MassTransferOrgRBC2BloodPool_Liv" dim="Amount per time" formula="IsLiverZonated ? 0 : (Q_liv +Q_pve)*HCT*C_bc">
         <Paths>
-          <Path path="25" as="41" dim="27" />
-          <Path path="42" as="43" dim="27" />
+          <Path path="31" as="48" dim="27" />
           <Path path="3" as="35" dim="5" />
-          <Path path="31" as="32" />
+          <Path path="29" as="30" />
+          <Path path="49" as="50" />
+          <Path path="51" as="52" dim="27" />
         </Paths>
       </Formula>
-      <Formula id="oM0yaU7dY0uJ6xPkcKFpAg" name="MassTransferOrgRBC2BloodPool" dim="Amount per time" formula="Q*HCT*C_bc">
+      <Formula id="Gn8c9i5H5kGLeCcuI_Z8AA" name="MassTransferOrgRBC2BloodPool_Liv_Pericentral" dim="Amount per time" formula="IsLiverZonated ? (Q_liv +Q_pve)*HCT*C_bc : 0">
         <Paths>
-          <Path path="25" as="41" dim="27" />
-          <Path path="3" as="28" dim="5" />
-          <Path path="31" as="32" />
+          <Path path="31" as="48" dim="27" />
+          <Path path="3" as="35" dim="5" />
+          <Path path="29" as="30" />
+          <Path path="49" as="50" />
+          <Path path="51" as="52" dim="27" />
         </Paths>
       </Formula>
-      <Formula id="yb7dmIuFQUm1tCMi-6r00g" name="MassTransferOrgRBC2BloodPool_Liv" dim="Amount per time" formula="IsLiverZonated ? 0 : (Q_liv +Q_pve)*HCT*C_bc">
+      <Formula id="f5TT10gFYEKs02S5O9FhhQ" name="MassTransferOrgRBC2BloodPool_Lng" dim="Amount per time" formula="Q*HCT*C_bc">
         <Paths>
-          <Path path="25" as="26" dim="27" />
-          <Path path="3" as="28" dim="5" />
-          <Path path="31" as="32" />
-          <Path path="33" as="34" />
-          <Path path="29" as="30" dim="27" />
+          <Path path="31" as="26" dim="27" />
+          <Path path="3" as="35" dim="5" />
+          <Path path="29" as="30" />
         </Paths>
       </Formula>
-      <Formula id="t9shxL8b20ah7YzO-C9UWg" name="MassTransferOrgRBC2BloodPool_Liv_Pericentral" dim="Amount per time" formula="IsLiverZonated ? (Q_liv +Q_pve)*HCT*C_bc : 0">
+      <Formula id="7hCZ2-rCK0KQs0QqiVmQRA" name="MassTransferOrgRBC2BloodPool_Pve" dim="Amount per time" formula="Q*HCT*C_bc">
         <Paths>
-          <Path path="25" as="26" dim="27" />
-          <Path path="3" as="28" dim="5" />
-          <Path path="31" as="32" />
-          <Path path="33" as="34" />
-          <Path path="29" as="30" dim="27" />
+          <Path path="31" as="26" dim="27" />
+          <Path path="3" as="35" dim="5" />
+          <Path path="29" as="30" />
         </Paths>
       </Formula>
-      <Formula id="kZ1y1zscvkSuC9etZ3HoGg" name="MassTransferOrgRBC2BloodPool_Lng" dim="Amount per time" formula="Q*HCT*C_bc">
+      <Formula id="kaWZ68yLyEmmEupureer3Q" name="MassTransferPeriportal2PericentralBC_liv" dim="Amount per time" formula="IsLiverZonated ? (Q_liv +Q_pve)*HCT*C_bc : 0">
         <Paths>
-          <Path path="25" as="41" dim="27" />
-          <Path path="3" as="28" dim="5" />
-          <Path path="31" as="32" />
+          <Path path="31" as="48" dim="27" />
+          <Path path="3" as="35" dim="5" />
+          <Path path="51" as="52" dim="27" />
+          <Path path="29" as="30" />
+          <Path path="49" as="50" />
         </Paths>
       </Formula>
-      <Formula id="IoxGtWM200SfrIZzXRFYZA" name="MassTransferOrgRBC2BloodPool_Pve" dim="Amount per time" formula="Q*HCT*C_bc">
+      <Formula id="StAVFVrYgE6fLQGS2Mr9hw" name="MassTransferPeriportal2PericentralPl_liv" dim="Amount per time" formula="IsLiverZonated ? ((Q_liv +Q_pve)*(1-HCT)-Q_lymph_periportal-Q_lymph_pve)*C_pls : 0">
         <Paths>
-          <Path path="25" as="41" dim="27" />
+          <Path path="31" as="48" dim="27" />
           <Path path="3" as="28" dim="5" />
-          <Path path="31" as="32" />
+          <Path path="51" as="52" dim="27" />
+          <Path path="29" as="30" />
+          <Path path="49" as="50" />
+          <Path path="53" as="54" dim="27" />
+          <Path path="55" as="56" dim="27" />
         </Paths>
       </Formula>
-      <Formula id="EHNWFBo-AUa0fuaQhro8Mg" name="NetMassTransfer_EndosomalToInterstitial_FcRn_Complex" dim="Amount per time" formula="(1-f_rec_vas)*K_rec*C_IgG_FcRn*V_end">
+      <Formula id="H30Otgu3Kk6TZFbJSu0qJA" name="NetMassTransfer_EndosomalToInterstitial_FcRn_Complex" dim="Amount per time" formula="(1-f_rec_vas)*K_rec*C_IgG_FcRn*V_end">
         <Paths>
           <Path path="59" as="60" dim="61" />
           <Path path="62" as="63" dim="11" />
@@ -1338,7 +1338,7 @@
           <Path path="6" as="7" dim="8" />
         </Paths>
       </Formula>
-      <Formula id="iGfN-2HZFUiUAnE3FQjL7Q" name="NetMassTransfer_EndosomalToPlasma_FcRn_Complex" dim="Amount per time" formula="f_rec_vas * K_rec * C_IgG_FcRn * V_end">
+      <Formula id="k_2EHMU2L0CHR9icDxbgmg" name="NetMassTransfer_EndosomalToPlasma_FcRn_Complex" dim="Amount per time" formula="f_rec_vas * K_rec * C_IgG_FcRn * V_end">
         <Paths>
           <Path path="59" as="60" dim="61" />
           <Path path="62" as="63" dim="11" />
@@ -1346,82 +1346,82 @@
           <Path path="6" as="7" dim="8" />
         </Paths>
       </Formula>
-      <Formula id="dKsGGleux0e_RwDOFnhM0w" name="NetMassTransfer_InterstitialToEndosomal" dim="Amount per time" formula="(1-f_uptake_vas)*(IsSmallMolecule ? 0 : K_uptake)*V_end*C_int">
+      <Formula id="tOHxG7eX9E6L8ihNtrvcpA" name="NetMassTransfer_InterstitialToEndosomal" dim="Amount per time" formula="(1-f_uptake_vas)*(IsSmallMolecule ? 0 : K_uptake)*V_end*C_int">
         <Paths>
           <Path path="65" as="66" dim="61" />
           <Path path="67" as="68" dim="11" />
-          <Path path="3" as="52" dim="5" />
+          <Path path="3" as="43" dim="5" />
           <Path path="69" as="70" />
           <Path path="71" as="7" dim="8" />
         </Paths>
       </Formula>
-      <Formula id="2thqorGNn0alJ-QfrsQ8dA" name="NetMassTransfer_InterstitialToEndosomal_FcRn" dim="Amount per time" formula="f_mem_int * (1-f_uptake_vas) * K_uptake * C_int * V_end">
+      <Formula id="9AgfFZ95rU-N9_p_c9kB4A" name="NetMassTransfer_InterstitialToEndosomal_FcRn" dim="Amount per time" formula="f_mem_int * (1-f_uptake_vas) * K_uptake * C_int * V_end">
         <Paths>
-          <Path path="72" as="73" />
           <Path path="65" as="66" dim="61" />
           <Path path="67" as="68" dim="11" />
-          <Path path="3" as="52" dim="5" />
+          <Path path="72" as="73" />
+          <Path path="3" as="43" dim="5" />
           <Path path="71" as="7" dim="8" />
         </Paths>
       </Formula>
-      <Formula id="AwtHpmg61k23OqJxYqcr4g" name="NetMassTransfer_InterstitialToEndosomal_LigandEndo" dim="Amount per time" formula="(1-f_uptake_vas) * K_uptake * V_end * C_int">
+      <Formula id="-knrI4Lq5UKSGx8DZPm0RA" name="NetMassTransfer_InterstitialToEndosomal_LigandEndo" dim="Amount per time" formula="(1-f_uptake_vas) * K_uptake * V_end * C_int">
         <Paths>
           <Path path="65" as="66" dim="61" />
           <Path path="67" as="68" dim="11" />
-          <Path path="3" as="52" dim="5" />
+          <Path path="3" as="43" dim="5" />
           <Path path="71" as="7" dim="8" />
         </Paths>
       </Formula>
-      <Formula id="HJnRovduM0Gx3ZFKRkripA" name="NetMassTransfer_PlasmaToEndosomal" dim="Amount per time" formula="f_uptake_vas*(IsSmallMolecule ? 0 : K_uptake)*V_end*C_pls">
+      <Formula id="7fdT_3PPM0GWQXuRWNpE-A" name="NetMassTransfer_PlasmaToEndosomal" dim="Amount per time" formula="f_uptake_vas*(IsSmallMolecule ? 0 : K_uptake)*V_end*C_pls">
         <Paths>
           <Path path="65" as="66" dim="61" />
           <Path path="67" as="68" dim="11" />
-          <Path path="3" as="35" dim="5" />
+          <Path path="3" as="28" dim="5" />
           <Path path="69" as="70" />
           <Path path="71" as="7" dim="8" />
         </Paths>
       </Formula>
-      <Formula id="pRDqVCPgkEKwX3dCKb1Zng" name="NetMassTransfer_PlasmaToEndosomal_FcRn" dim="Amount per time" formula="f_mem_pls * f_uptake_vas * K_uptake * C_pls * V_end">
+      <Formula id="bC1tPzgJ90GHF8Kr89aGbw" name="NetMassTransfer_PlasmaToEndosomal_FcRn" dim="Amount per time" formula="f_mem_pls * f_uptake_vas * K_uptake * C_pls * V_end">
         <Paths>
-          <Path path="74" as="75" />
           <Path path="65" as="66" dim="61" />
           <Path path="67" as="68" dim="11" />
-          <Path path="3" as="35" dim="5" />
+          <Path path="74" as="75" />
+          <Path path="3" as="28" dim="5" />
           <Path path="71" as="7" dim="8" />
         </Paths>
       </Formula>
-      <Formula id="2I1wunPZN0ur-e5CaC4GJw" name="NetMassTransfer_PlasmaToEndosomal_LigandEndo" dim="Amount per time" formula="f_uptake_vas * K_uptake * V_end * C_pls">
+      <Formula id="UUmz55RSFEe_BDOt-l0mvA" name="NetMassTransfer_PlasmaToEndosomal_LigandEndo" dim="Amount per time" formula="f_uptake_vas * K_uptake * V_end * C_pls">
         <Paths>
           <Path path="65" as="66" dim="61" />
           <Path path="67" as="68" dim="11" />
-          <Path path="3" as="35" dim="5" />
+          <Path path="3" as="28" dim="5" />
           <Path path="71" as="7" dim="8" />
         </Paths>
       </Formula>
-      <Formula id="N1PcG8LEakSXa229OrHLwg" name="PassiveDiffusionInt2Cell" dim="Amount per time" formula="K_water_int * PA_int_cell * C_int - K_water_cell * PA_cell_int * C_cell">
+      <Formula id="6et2C619oECa6yQvCD6UlQ" name="PassiveDiffusionInt2Cell" dim="Amount per time" formula="K_water_int * PA_int_cell * C_int - K_water_cell * PA_cell_int * C_cell">
         <Paths>
           <Path path="76" as="77" dim="5" />
-          <Path path="3" as="52" dim="5" />
+          <Path path="3" as="43" dim="5" />
           <Path path="78" as="79" dim="27" />
           <Path path="80" as="81" dim="27" />
           <Path path="82" as="83" />
           <Path path="84" as="85" />
         </Paths>
       </Formula>
-      <Formula id="gaeuJWqVJESJGx0-czs_VQ" name="PassiveDiffusionPl2Int" dim="Amount per time" formula="fu * P_endothelial * SA * (C_pls - C_int / K_int_pls)">
+      <Formula id="CuwFkiPRBU-iTCDknL1L5g" name="PassiveDiffusionPl2Int" dim="Amount per time" formula="fu * P_endothelial * SA * (C_pls - C_int / K_int_pls)">
         <Paths>
-          <Path path="76" as="52" dim="5" />
-          <Path path="3" as="35" dim="5" />
+          <Path path="76" as="43" dim="5" />
+          <Path path="3" as="28" dim="5" />
           <Path path="86" as="87" dim="61" />
           <Path path="88" as="89" dim="90" />
           <Path path="91" as="92" />
           <Path path="93" as="94" dim="95" />
         </Paths>
       </Formula>
-      <Formula id="hUoty0fZUEmbNXblsAJCEA" name="PassiveDiffusionPl2RBC" dim="Amount per time" formula="SA_bc * fu * (P_pls_rbc * C_pls - P_rbc_pls * C_bc  /K_rbc)">
+      <Formula id="o07RWWggjEyk0-rCdyS1Hw" name="PassiveDiffusionPl2RBC" dim="Amount per time" formula="SA_bc * fu * (P_pls_rbc * C_pls - P_rbc_pls * C_bc  /K_rbc)">
         <Paths>
-          <Path path="76" as="28" dim="5" />
-          <Path path="3" as="35" dim="5" />
+          <Path path="76" as="35" dim="5" />
+          <Path path="3" as="28" dim="5" />
           <Path path="86" as="87" dim="61" />
           <Path path="96" as="97" dim="90" />
           <Path path="98" as="99" dim="90" />
@@ -1429,7 +1429,7 @@
           <Path path="102" as="103" dim="95" />
         </Paths>
       </Formula>
-      <Formula id="a2zuIDMdHU6WuGwi-4LG1A" name="PassiveDiffusionPlsToSaliva" dim="Amount per time" formula="fu * (C_pls_art - C_slv / K_slv_pls) * Q_slv">
+      <Formula id="TwFF8l2dIUehLOHlLMW2tA" name="PassiveDiffusionPlsToSaliva" dim="Amount per time" formula="fu * (C_pls_art - C_slv / K_slv_pls) * Q_slv">
         <Paths>
           <Path path="104" as="105" dim="27" />
           <Path path="106" as="107" dim="5" />
@@ -1438,12 +1438,12 @@
           <Path path="109" as="110" />
         </Paths>
       </Formula>
-      <Formula id="dvoepzPjOUatNp_hrvsH2A" name="TwoPoresTransportLink" dim="Amount per time" formula="fu * ((J_iso+alpha_l*Q_lymph)*(1-sigma_l)*C_pl+(P_endothelial_l*SA_pls_int)*(C_pl-C_int/K_int_pls)*Pe_l/(exp(Pe_l)-1) + (-J_iso+(1-alpha_l)*Q_lymph)*(1-sigma_s)*C_pl+(P_endothelial_s*SA_pls_int)*(C_pl-C_int/K_int_pls)*Pe_s/(exp(Pe_s)-1))">
+      <Formula id="Nvii8q8x40-8UjiYe-MSxg" name="TwoPoresTransportLink" dim="Amount per time" formula="fu * ((J_iso+alpha_l*Q_lymph)*(1-sigma_l)*C_pl+(P_endothelial_l*SA_pls_int)*(C_pl-C_int/K_int_pls)*Pe_l/(exp(Pe_l)-1) + (-J_iso+(1-alpha_l)*Q_lymph)*(1-sigma_s)*C_pl+(P_endothelial_s*SA_pls_int)*(C_pl-C_int/K_int_pls)*Pe_s/(exp(Pe_s)-1))">
         <Paths>
           <Path path="111" as="112" />
           <Path path="113" as="114" dim="27" />
-          <Path path="42" as="43" dim="27" />
-          <Path path="76" as="52" dim="5" />
+          <Path path="32" as="33" dim="27" />
+          <Path path="76" as="43" dim="5" />
           <Path path="3" as="115" dim="5" />
           <Path path="86" as="87" dim="61" />
           <Path path="116" as="117" dim="90" />
@@ -1456,23 +1456,23 @@
           <Path path="93" as="128" dim="95" />
         </Paths>
       </Formula>
-      <Formula id="FXpV8OYX6Uu7anrG9f8kkA" name="TwoPoresTransportLink_igg" dim="Amount per time" formula="(J_iso+alpha_l*Q_lymph)*(1-sigma_l)*C_pl+(P_endothelial_l*SA_pls_int)*(C_pl-C_int)*Pe_l/(exp(Pe_l)-1) + (-J_iso+(1-alpha_l)*Q_lymph)*(1-sigma_s)*C_pl+(P_endothelial_s*SA_pls_int)*(C_pl-C_int)*Pe_s/(exp(Pe_s)-1)">
+      <Formula id="AKfeCsyEZkWByVzs37q-Rg" name="TwoPoresTransportLink_igg" dim="Amount per time" formula="(J_iso+alpha_l*Q_lymph)*(1-sigma_l)*C_pl+(P_endothelial_l*SA_pls_int)*(C_pl-C_int)*Pe_l/(exp(Pe_l)-1) + (-J_iso+(1-alpha_l)*Q_lymph)*(1-sigma_s)*C_pl+(P_endothelial_s*SA_pls_int)*(C_pl-C_int)*Pe_s/(exp(Pe_s)-1)">
         <Paths>
           <Path path="111" as="112" />
           <Path path="113" as="114" dim="27" />
-          <Path path="42" as="43" dim="27" />
+          <Path path="32" as="33" dim="27" />
           <Path path="129" as="117" dim="90" />
           <Path path="130" as="119" dim="90" />
           <Path path="131" as="121" />
           <Path path="132" as="123" />
           <Path path="133" as="125" />
           <Path path="134" as="127" />
-          <Path path="76" as="52" dim="5" />
+          <Path path="76" as="43" dim="5" />
           <Path path="3" as="115" dim="5" />
           <Path path="93" as="128" dim="95" />
         </Paths>
       </Formula>
-      <Formula id="8L9SRwGqxkO0Cfj-1vHCzA" name="GallbladderEmptyingRate" dim="Amount per time" formula="EHC_Active ? ln(2) / EHC_Halftime * M * EHC_EjectionFraction : 0">
+      <Formula id="QcAxpJ5rGUiiG1Px0HWEbw" name="GallbladderEmptyingRate" dim="Amount per time" formula="EHC_Active ? ln(2) / EHC_Halftime * M * EHC_EjectionFraction : 0">
         <Paths>
           <Path path="135" as="136" dim="18" />
           <Path path="137" as="138" dim="61" />
@@ -1507,38 +1507,38 @@
       <Map s="w" id="22" />
       <Map s="TARGET|FillLevelFlag" id="23" />
       <Map s="FillLevelFlagNext" id="24" />
-      <Map s="SOURCE|..|Blood flow rate" id="25" />
-      <Map s="Q_liv" id="26" />
+      <Map s="TARGET|..|Blood flow rate" id="25" />
+      <Map s="Q" id="26" />
       <Map s="Flow" id="27" />
-      <Map s="C_bc" id="28" />
-      <Map s="Organism|PortalVein|Blood flow rate" id="29" />
-      <Map s="Q_pve" id="30" />
-      <Map s="Organism|Hematocrit" id="31" />
-      <Map s="HCT" id="32" />
-      <Map s="Organism|Liver|Is liver zonated" id="33" />
-      <Map s="IsLiverZonated" id="34" />
-      <Map s="C_pls" id="35" />
-      <Map s="Organism|PortalVein|Lymph flow rate" id="36" />
-      <Map s="Q_lymph_pve" id="37" />
-      <Map s="Organism|Liver|Periportal|Lymph flow rate" id="38" />
-      <Map s="Q_lymph_periportal" id="39" />
-      <Map s="TARGET|..|Blood flow rate" id="40" />
-      <Map s="Q" id="41" />
-      <Map s="SOURCE|..|Lymph flow rate" id="42" />
-      <Map s="Q_lymph" id="43" />
-      <Map s="TARGET|..|Lymph flow rate" id="44" />
-      <Map s="SOURCE|..|Mucosa blood flow fraction" id="45" />
-      <Map s="fractQ" id="46" />
-      <Map s="C" id="47" />
-      <Map s="NEIGHBORHOOD|MOLECULE|Mass transfer rate (intestine to mucosa blood cells)" id="48" />
-      <Map s="MassTransferIntestineToMucosaBCRate" id="49" />
-      <Map s="NEIGHBORHOOD|MOLECULE|Mass transfer rate (intestine to mucosa plasma)" id="50" />
-      <Map s="MassTransferIntestineToMucosaPlasmaRate" id="51" />
-      <Map s="C_int" id="52" />
-      <Map s="NEIGHBORHOOD|MOLECULE|Mass transfer rate (mucosa to portal vein blood cells)" id="53" />
-      <Map s="MassTransferMucosaToPveBCRate" id="54" />
-      <Map s="NEIGHBORHOOD|MOLECULE|Mass transfer rate (mucosa to portal vein plasma)" id="55" />
-      <Map s="MassTransferMucosaToPvePlasmaRate" id="56" />
+      <Map s="C_pls" id="28" />
+      <Map s="Organism|Hematocrit" id="29" />
+      <Map s="HCT" id="30" />
+      <Map s="SOURCE|..|Blood flow rate" id="31" />
+      <Map s="SOURCE|..|Lymph flow rate" id="32" />
+      <Map s="Q_lymph" id="33" />
+      <Map s="TARGET|..|Lymph flow rate" id="34" />
+      <Map s="C_bc" id="35" />
+      <Map s="NEIGHBORHOOD|MOLECULE|Mass transfer rate (intestine to mucosa blood cells)" id="36" />
+      <Map s="MassTransferIntestineToMucosaBCRate" id="37" />
+      <Map s="NEIGHBORHOOD|MOLECULE|Mass transfer rate (intestine to mucosa plasma)" id="38" />
+      <Map s="MassTransferIntestineToMucosaPlasmaRate" id="39" />
+      <Map s="SOURCE|..|Mucosa blood flow fraction" id="40" />
+      <Map s="fractQ" id="41" />
+      <Map s="C" id="42" />
+      <Map s="C_int" id="43" />
+      <Map s="NEIGHBORHOOD|MOLECULE|Mass transfer rate (mucosa to portal vein blood cells)" id="44" />
+      <Map s="MassTransferMucosaToPveBCRate" id="45" />
+      <Map s="NEIGHBORHOOD|MOLECULE|Mass transfer rate (mucosa to portal vein plasma)" id="46" />
+      <Map s="MassTransferMucosaToPvePlasmaRate" id="47" />
+      <Map s="Q_liv" id="48" />
+      <Map s="Organism|Liver|Is liver zonated" id="49" />
+      <Map s="IsLiverZonated" id="50" />
+      <Map s="Organism|PortalVein|Blood flow rate" id="51" />
+      <Map s="Q_pve" id="52" />
+      <Map s="Organism|PortalVein|Lymph flow rate" id="53" />
+      <Map s="Q_lymph_pve" id="54" />
+      <Map s="Organism|Liver|Periportal|Lymph flow rate" id="55" />
+      <Map s="Q_lymph_periportal" id="56" />
       <Map s="Organism|Liver|Pericentral|Lymph flow rate" id="57" />
       <Map s="Q_lymph_pericentral" id="58" />
       <Map s="SOURCE|..|Fraction recycled to plasma" id="59" />
diff --git a/src/Data/Templates/Human 2 Pores.pkml b/src/Data/Templates/Human 2 Pores.pkml
index aaee7dfd9..c745e7241 100644
--- a/src/Data/Templates/Human 2 Pores.pkml	
+++ b/src/Data/Templates/Human 2 Pores.pkml	
@@ -1,364 +1,367 @@
 <?xml version="1.0" encoding="utf-8"?>
-<SpatialStructure id="fa6-tsK3UEKw0I1uCVxKZA" name="Human 2 Pores" icon="SpatialStructure" bbVersion="0" version="13">
-  <Creation createdAt="5248308555546863607" createdBy="EZZJY" creationMode="New" origin="PKSim" version="7.3.0" internalVersion="74" />
-  <GlobalMoleculeDependentProperties id="IyR6wl2MVEyClEYNndfWqA" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+<SpatialStructure id="lIAqFHTqSUS6_bmjLd5mgA" name="Human 2 Pores" icon="SpatialStructure" bbVersion="0" version="14">
+  <Creation createdAt="5248852327686374929" createdBy="Michael" creationMode="New" origin="PKSim" version="9.0" internalVersion="77" />
+  <GlobalMoleculeDependentProperties id="XSISjLdq5U6FRC9QPdeGtg" name="MoleculeProperties" mode="Logical" containerType="Molecule">
     <Children>
-      <Parameter id="xkOx6d_2mEGwZQ4ggiVZUg" name="Mucosa permeability scale factor (transcellular)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_MucosaPermeabilityScaleFactor_trans" buildMode="Global" isDefault="1">
+      <Parameter id="b9TPnZ3AnkW8ZSOst2ua1g" name="Default Intestinal permeability (transcellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_default" buildMode="Global" isDefault="1" displayUnit="cm/min">
         <Info min="0" flag="52" seq="1" ref="0" bb="2" group="75" />
       </Parameter>
-      <Parameter id="8P1sdnHdn0m-S7vSxcnv_w" name="Partition coefficient (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" buildMode="Global" isDefault="1">
-        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="67" />
+      <Parameter id="_UrRvhmfXUGqpuZ29UBlXQ" name="Intestinal permeability (paracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Global" isDefault="1" value="0" displayUnit="cm/min">
+        <ValueOrigin id="47" source="Publication" description="Kuepfer, L., Niederalt, C., Wendl, T., Schlender, J.-F., Willmann, S., Lippert, J., Block, M., Eissing, T. and Teutonico, D. (2016), Applied Concepts in PBPK Modeling: How to Build a PBPK/PD Model. CPT Pharmacometrics Syst. Pharmacol., 5: 516–531. doi:10." />
+        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="75" />
       </Parameter>
-      <Parameter id="JAD0xjpt-0W7Px3B53HsJw" name="P_pls_bc_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" buildMode="Global" isDefault="1">
-        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+      <Parameter id="ReHPUuaJLU6UktIlrMDjlw" name="Intestinal permeability (transcellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int" buildMode="Global" isDefault="1" displayUnit="cm/min">
+        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="75" />
       </Parameter>
-      <Parameter id="UpjfUMyxAEyAP255nEa9Bw" name="P_bc_pls_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" buildMode="Global" isDefault="1">
-        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+      <Parameter id="w9-nj1eqbUK-l3UWQm8Xfw" name="Mucosa permeability scale factor (transcellular)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_MucosaPermeabilityScaleFactor_trans" buildMode="Global" isDefault="1">
+        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="75" />
       </Parameter>
-      <Parameter id="Ouc7kNrjK0upFqDVG5rzaA" name="P (blood cells-&gt;plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_rbc_pls" buildMode="Global" isDefault="1" displayUnit="cm/min">
+      <Parameter id="JG3h038rYEyO-xfpBT3aLA" name="P (blood cells-&gt;plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_rbc_pls" buildMode="Global" isDefault="1" displayUnit="cm/min">
         <Info min="0" flag="122" seq="1" ref="0" bb="2" group="75" />
       </Parameter>
-      <Parameter id="C9FEi4B1KUyKP2wGzamvHg" name="Intestinal permeability (transcellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int" buildMode="Global" isDefault="1" displayUnit="cm/min">
+      <Parameter id="L3vN-yhntEW_SB9UgjZ5wQ" name="P (plasma-&gt;blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_pls_rbc" buildMode="Global" isDefault="1" displayUnit="cm/min">
         <Info min="0" flag="122" seq="1" ref="0" bb="2" group="75" />
       </Parameter>
-      <Parameter id="74FxZJzp-E2CBe-fD85ymQ" name="Intestinal permeability (paracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Global" isDefault="1" value="0" displayUnit="cm/min">
-        <ValueOrigin id="47" source="Publication" description="Kuepfer, L., Niederalt, C., Wendl, T., Schlender, J.-F., Willmann, S., Lippert, J., Block, M., Eissing, T. and Teutonico, D. (2016), Applied Concepts in PBPK Modeling: How to Build a PBPK/PD Model. CPT Pharmacometrics Syst. Pharmacol., 5: 516–531. doi:10." />
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+        <DistributedParameter id="nd4L2UCxYE2CifTJdy0c0w" name="MeanHeight" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="ONHodN7MZ06diK4pNpODsQ" mode="Logical" isDefault="1" displayUnit="cm">
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+            <Parameter id="dZj78yKv80awP__xG74UPA" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="17.6" displayUnit="cm">
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+            <Parameter id="VTtb5vvJkUiJG-ZpnrYRFQ" name="Deviation" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.88" displayUnit="cm">
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-        <Container id="_fMZGncsxEOHRcaEk9WdrQ" name="VenousBlood" mode="Logical" containerType="Organ">
+        <Container id="KcYhRxK6AkahhNAPm8sRdg" name="PeripheralVenousBlood" mode="Logical" containerType="Organ" />
+        <Container id="HKBfKEMfdEa5WzD_fGXUEw" name="VenousBlood" mode="Logical" containerType="Organ">
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+            <Parameter id="gxW_wFzdfUOyem107GufGA" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
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+            <Parameter id="xr9UNXwHuEi2_wpSqVuVgA" name="Density (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
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+            <Parameter id="AGKYksX880axGW-BzMpqoA" name="Allometric scale factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.75">
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+            <Parameter id="FV8A-XWe9kaGdchXv4jG-Q" name="Fraction vascular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
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+            <DistributedParameter id="Go-4dPDOp06X6B1olLt5vg" name="Volume" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="B7Fm5qjspkymnN6txfso4w" mode="Logical" isDefault="1" displayUnit="l">
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-                <Parameter id="YTEHYCGk-kOnCgIsmCfqpQ" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.500946524244908" displayUnit="l">
+                <Parameter id="foPY79BV1E6Off88YlnYjw" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.501368391208651" displayUnit="l">
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+                <Parameter id="Ay6xwvTrpEClRHltQSpGxw" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.963884723" displayUnit="l">
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                 </Parameter>
-                <Parameter id="ZU50WhIcK0ukl_sMS1JQzA" name="Deviation" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.038826594" displayUnit="l">
+                <Parameter id="2_xJ3tjurkGf9wz8KXFKLA" name="Deviation" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.048194236" displayUnit="l">
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                 </Parameter>
               </Children>
               <Tags>
                 <Tag value="BloodOrgan" />
               </Tags>
+              <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
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             </DistributedParameter>
-            <Container id="lg3JPjAHSUaKoE7vwc_rTw" name="Plasma" mode="Physical" containerType="Compartment">
+            <Container id="JxP9aCWtgUGhXH_R7w1Z2Q" name="Plasma" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="BloodOrgan" />
                 <Tag value="VenousBlood" />
               </Tags>
               <Children>
-                <Parameter id="PyP4Zc0rlUquHqF4rhSRkg" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                <Parameter id="s2GY8dH19EWevJp_3SY8tQ" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
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                 </Parameter>
-                <Parameter id="DTYsw1B6G0aSuQo70EJNfA" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_pls_BloodOrgan_2Pores" isDefault="1" displayUnit="l">
+                <Parameter id="N9sKRXtsCU2gusN9BdEwnA" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_pls_BloodOrgan_2Pores" isDefault="1" displayUnit="l">
                   <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                   <Info min="0" flag="62" seq="3" ref="0" bb="2" group="126" />
                 </Parameter>
-                <Container id="vwZSSvWpGk-MfAxJ4wQHaA" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="phgPUw82SkKWghMjbP_SZQ" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                   <Children>
-                    <Parameter id="OB_UKNZQIUqiyzn7e7W2Cw" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Plasma_and_Interstitial" isDefault="1" displayUnit="µmol/l">
+                    <Parameter id="iggAYfxyL0avGg2qOL9otA" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Plasma_and_Interstitial" isDefault="1" displayUnit="µmol/l">
                       <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
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                     </Parameter>
-                    <Parameter id="c75aleqpMkqiFHbHedxSnA" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                    <Parameter id="yP8YA89a7UOAtGsvaoTcBw" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                     </Parameter>
-                    <Parameter id="gM6ZbXHucEOmWk8Jp0-KKQ" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" isDefault="1">
+                    <Parameter id="uGBV-Ncu9Equh33w5kfAmA" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                     </Parameter>
-                    <Parameter id="JawUBxUrEUK1yvnV9TqfYw" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
+                    <Parameter id="z5Yh_PPtVkatAfsViomCHQ" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
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                 </Container>
               </Children>
             </Container>
-            <Container id="BvN_npw9ekupr6uHYGaj_g" name="BloodCells" mode="Physical" containerType="Compartment">
+            <Container id="s69zFizy-UefsPiLLFllaw" name="BloodCells" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="BloodOrgan" />
                 <Tag value="VenousBlood" />
               </Tags>
               <Children>
-                <Parameter id="d2CtykAS40Km9RZtbf5ZzQ" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                <Parameter id="2fHuBdj0P0e4pAIJKkjSgA" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
                   <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                 </Parameter>
-                <Parameter id="qk16t8TWwE6mS2K7KQ9U3w" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_bc_blood_organ_2Pores" isDefault="1" displayUnit="l">
+                <Parameter id="tP47pYQvuEGxN--VLUdntw" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_bc_blood_organ_2Pores" isDefault="1" displayUnit="l">
                   <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                   <Info min="0" flag="62" seq="3" ref="0" bb="2" group="121" />
                 </Parameter>
-                <Container id="wrxDyZPjp02KzKGWIxnO0Q" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="B4h5-9Y-4kWTEqHuopkwwA" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                   <Children>
-                    <Parameter id="caGnj8obpEysi95iVB4Bdg" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                    <Parameter id="6sQKs67H00KF5ZiefnGtPQ" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                     </Parameter>
-                    <Parameter id="EZKWLBmMskyNglZtZIZvTQ" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" isDefault="1">
+                    <Parameter id="1cS7fb7aFUGWFp4j5RobLQ" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                     </Parameter>
-                    <Parameter id="G8EAgvgUNEq9GpeHcUy8sA" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
+                    <Parameter id="GW0YvoaTP0qK0tVI52-kMA" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
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@@ -367,113 +370,114 @@
             </Container>
           </Children>
         </Container>
-        <Container id="F3_B_EzFwky_KXJDJ06kFA" name="ArterialBlood" mode="Logical" containerType="Organ">
+        <Container id="2V2_jFN6k0uMkOaIORT1zg" name="ArterialBlood" mode="Logical" containerType="Organ">
           <Tags>
             <Tag value="BloodOrgan" />
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+            <Parameter id="UkFFpwT2M0GDnq_ALCkNzg" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
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                 <Tag value="BloodOrgan" />
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               <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
             </Parameter>
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+            <Parameter id="nCUV67Bh30W8NF-34JfV9g" name="Density (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
               <Tags>
                 <Tag value="BloodOrgan" />
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               <Info min="0" flag="38" seq="1" ref="0" bb="32" group="21" />
             </Parameter>
-            <Parameter id="eBZ3a6vp902CuFN673qQWg" name="Peripheral blood flow fraction" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0">
+            <Parameter id="e2I1Kyc8e0qloZSLCwDCaQ" name="Peripheral blood flow fraction" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0">
               <Tags>
                 <Tag value="BloodOrgan" />
               </Tags>
               <ValueOrigin id="46" source="Publication" description="Thiel C, Schneckener S, Krauss M, Ghallab A, Hofmann U, et al. A systematic evaluation of the use of physiologically based pharmacokinetic modeling for cross-species extrapolation. J Pharm Sci. 2015 Jan;104(1):191-206 https://doi.org/10.1002/jps.24214" />
               <Info min="0" max="1" flag="122" seq="1" ref="0" bb="32" group="74" />
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+            <Parameter id="xKdgjSqp0kS5LCFBw8Ny3g" name="Allometric scale factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.75">
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                 <Tag value="BloodOrgan" />
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               <Info min="0.75" max="0.75" flag="52" seq="1" ref="0" bb="32" group="2" />
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+            <Parameter id="b3rssy5_xE-kKIZB_iR6ew" name="Fraction vascular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
               <Tags>
                 <Tag value="BloodOrgan" />
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               <Info min="0" max="1" flag="62" seq="12" ref="0" bb="32" group="64" />
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+            <DistributedParameter id="A7vRQWTYGUq3bMBPv2Yqow" name="Volume" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="seYAGvMrtUyrs35sto2_5w" mode="Logical" isDefault="1" displayUnit="l">
               <Children>
-                <Parameter id="CM5HvjHPYkC5c8IE2AYGqQ" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.500256823513264" displayUnit="l">
+                <Parameter id="Wdi_dL-Ybk2rHU0zPp2BmQ" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.50020155879836" displayUnit="l">
                   <Info min="0" flag="18" seq="1" ref="0" bb="32" group="65" />
                 </Parameter>
-                <Parameter id="6sDdURHzpEm0FiXPnL-vqA" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.337622553" displayUnit="l">
+                <Parameter id="cautbOTjXUq3NHOYaAbY8w" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.419080314" displayUnit="l">
                   <Info min="0" flag="34" seq="1" ref="0" bb="32" group="65" />
                 </Parameter>
-                <Parameter id="qHdeNG9eMk2a4p9P4I-Edw" name="Deviation" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.016881128" displayUnit="l">
+                <Parameter id="cJMA5HD1_EeJjhaf6umqXw" name="Deviation" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.020954016" displayUnit="l">
                   <Info min="0" flag="18" seq="1" ref="0" bb="32" group="65" />
                 </Parameter>
               </Children>
               <Tags>
                 <Tag value="BloodOrgan" />
               </Tags>
+              <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
               <Info min="0" flag="106" seq="1" ref="0" bb="32" group="65" />
             </DistributedParameter>
-            <Container id="4825D6NCvEaDod9eLrQ1OQ" name="Plasma" mode="Physical" containerType="Compartment">
+            <Container id="8w_HEBIvlUCHJDlw_MvzWw" name="Plasma" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="ArterialBlood" />
                 <Tag value="BloodOrgan" />
               </Tags>
               <Children>
-                <Parameter id="jptYZNqWDUW0Cg27kME3Dw" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                <Parameter id="9DqdLlWe702kiZ-RFrABEA" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
                   <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                 </Parameter>
-                <Parameter id="Zu5xjUQL7Eyr4FY-EXeBVg" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_pls_BloodOrgan_2Pores" isDefault="1" displayUnit="l">
+                <Parameter id="uZ829juphUaTs1L70viEHA" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_pls_BloodOrgan_2Pores" isDefault="1" displayUnit="l">
                   <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                   <Info min="0" flag="62" seq="4" ref="0" bb="2" group="126" />
                 </Parameter>
-                <Container id="k4PYjMc43EG81ULJPLS78g" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="i3uSbbwCkEWTWLxPa2qSoQ" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                   <Children>
-                    <Parameter id="aU9_UhEeVEqoLQZJuk44_Q" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
-                      <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
-                    </Parameter>
-                    <Parameter id="fQA-P-kyIUSvRt10gpON1g" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Plasma_and_Interstitial" isDefault="1" displayUnit="µmol/l">
+                    <Parameter id="FnjULY1d1k6MJ1p7Adkofw" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Plasma_and_Interstitial" isDefault="1" displayUnit="µmol/l">
                       <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                       <Info flag="52" seq="1" ref="0" bb="2" group="25" />
                     </Parameter>
-                    <Parameter id="iykO31dfeEWMu9XReFnb5g" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" isDefault="1">
+                    <Parameter id="EuMrertSUES3HoEsdcd_fg" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                    </Parameter>
+                    <Parameter id="ztDTQvFqkkqpJLLtE9kq9w" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                     </Parameter>
-                    <Parameter id="QsvXaTdj_02tovnHs6A_qA" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
-                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                    <Parameter id="zCd8i7cTt0yP054HZX-Ucw" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
+                      <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                     </Parameter>
                   </Children>
                 </Container>
               </Children>
             </Container>
-            <Container id="b_JwGFelbkeRco3dQKg62Q" name="BloodCells" mode="Physical" containerType="Compartment">
+            <Container id="IhEBMJxutUm85iXU4_r5iQ" name="BloodCells" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="ArterialBlood" />
                 <Tag value="BloodOrgan" />
               </Tags>
               <Children>
-                <Parameter id="dMXK3oGBCUW4EXSZaNEsTQ" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                <Parameter id="mAtvcmc16EuF8sMjr0MLZw" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
                   <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                 </Parameter>
-                <Parameter id="eilO8Ym2N0y2DsdqwqVgmA" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_bc_blood_organ_2Pores" isDefault="1" displayUnit="l">
+                <Parameter id="39fwQeSAVkKx_HuuV9B-8g" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_bc_blood_organ_2Pores" isDefault="1" displayUnit="l">
                   <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                   <Info min="0" flag="62" seq="4" ref="0" bb="2" group="121" />
                 </Parameter>
-                <Container id="4XrKPJvbqUKj0-EdrjX7bA" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="5_xgeEa8yUCz6eGK2UpxRQ" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                   <Children>
-                    <Parameter id="qAb41rNIu0mNgQtCzZMcIg" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                    <Parameter id="VXbw36aNa0O1-8BhQu0-Dg" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                     </Parameter>
-                    <Parameter id="rJ1EjmYq6kq59Ly_Bog2YQ" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" isDefault="1">
+                    <Parameter id="xmuxnyPLVEq9tKKfvZeToQ" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                     </Parameter>
-                    <Parameter id="tXqeGgyytkCPUieIFqHI2A" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
+                    <Parameter id="A_hNqCFxa0KbOp1nO6nH0A" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
                       <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                     </Parameter>
                   </Children>
@@ -482,481 +486,483 @@
             </Container>
           </Children>
         </Container>
-        <Container id="wYCBobP02kWiYG0IF2cGrQ" name="Bone" mode="Logical" containerType="Organ">
+        <Container id="3fiyperf702fENc82WBivg" name="Bone" mode="Logical" containerType="Organ">
           <Tags>
             <Tag value="TissueOrgan" />
           </Tags>
           <Children>
-            <Parameter id="fo09buBiaUOYVJOa3SAZmA" name="Fraction of endosomal uptake from plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_uptake_vas" isDefault="1">
+            <Parameter id="8g3GimMVBUCc4rHKNnRzvA" name="Fraction of endosomal uptake from plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_uptake_vas" isDefault="1">
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
               <Info min="0" flag="54" seq="0" ref="0" bb="2" group="25" />
             </Parameter>
-            <Parameter id="MnHxe3CpnEGnWCOf1zwHsg" name="Fraction endosomal" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_endo" isDefault="1">
+            <Parameter id="GU0uDswFQEaEcOAVWqEayQ" name="Fraction endosomal" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_endo" isDefault="1">
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
               <Info min="0" max="1" flag="54" seq="1" ref="0" bb="2" group="29" />
             </Parameter>
-            <Parameter id="BKzIe_10HkW4Sg9KD_5OkQ" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
-              <Tags>
-                <Tag value="TissueOrgan" />
-              </Tags>
-              <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
-            </Parameter>
-            <Parameter id="Qt9RqUYhJUyadKosZbdtUw" name="Rate constant for recycling from endosomal space" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_K_rec" isDefault="1" displayUnit="1/min">
+            <Parameter id="8eqssxDuRkG6cQp5kt8siw" name="Fraction recycled to plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_rec_vas" isDefault="1">
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
               <Info min="0" flag="54" seq="1" ref="0" bb="2" group="25" />
             </Parameter>
-            <Parameter id="2tS23wtmyEOmu0SuQjaglw" name="Rate constant for endosomal uptake" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_K_uptake" isDefault="1" displayUnit="1/min">
+            <Parameter id="KedWAnK3N0yir1CN9HlVlQ" name="Rate constant for endosomal uptake" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_K_uptake" isDefault="1" displayUnit="1/min">
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
               <Info min="0" flag="54" seq="1" ref="0" bb="2" group="25" />
             </Parameter>
-            <Parameter id="UWc4-mNzy0-jB9wwr54haw" name="Fraction recycled to plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_rec_vas" isDefault="1">
+            <Parameter id="tjf5iQwY_UuwgXX0ZHBn7g" name="Rate constant for recycling from endosomal space" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_K_rec" isDefault="1" displayUnit="1/min">
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
               <Info min="0" flag="54" seq="1" ref="0" bb="2" group="25" />
             </Parameter>
-            <Parameter id="rnaPq1S4pkS48TdkLEgM-w" name="Blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_from_Qspec" isDefault="1" displayUnit="l/min">
+            <Parameter id="2UbFKrBzCkeBhmUxuCRuiA" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
+              <Tags>
+                <Tag value="TissueOrgan" />
+              </Tags>
+              <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
+            </Parameter>
+            <Parameter id="bGW2idgJ-E225T-60dWZqQ" name="Blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_from_Qspec" isDefault="1" displayUnit="l/min">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
-              <ValueOrigin id="48" description="TODO: Absolute from specific calculation" />
+              <ValueOrigin id="48" source="Other" description="Absolute value = specific value (i.e. value normalized to the volume of the organ) multiplied by the organ volume" />
               <Info min="0" flag="62" seq="2" ref="0" bb="32" group="5" />
             </Parameter>
-            <Parameter id="jwufNnODo0OVuGJNdE6ong" name="Fluid recirculation flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate" isDefault="1" displayUnit="l/min">
+            <Parameter id="9OhmEG0j0E2HMwcGe-iQiw" name="Fluid recirculation flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate" isDefault="1" displayUnit="l/min">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
               <Info min="0" flag="122" seq="5" ref="0" bb="32" group="27" />
             </Parameter>
-            <Parameter id="O8cTQjNeQ0yvOQRu_lWxWA" name="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Lymph_flow_rate" isDefault="1" displayUnit="l/min">
+            <Parameter id="4Chi_eiPjEmPzpAGDqjgMQ" name="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Lymph_flow_rate" isDefault="1" displayUnit="l/min">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
               <Info min="0" flag="122" seq="5" ref="0" bb="32" group="58" />
             </Parameter>
-            <Parameter id="C7yAZKLs3kGaq71OtR95bg" name="Volume (endothelium)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="VascularEndoVolume.VOLUME_VascularEndo_bon" isDefault="1" displayUnit="l">
+            <Parameter id="UB_XbmeBBU67hGMCczGf5Q" name="Volume (endothelium)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="VascularEndoVolume.VOLUME_VascularEndo_bon" isDefault="1" displayUnit="l">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" flag="62" seq="5" ref="0" bb="32" group="127" />
             </Parameter>
-            <Parameter id="-gz05518U06NRDaYJjh0jw" name="Fraction intracellular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_f_cell" isDefault="1">
+            <Parameter id="SPPj5Nqta02r9ux10G1F-Q" name="Fraction intracellular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_f_cell" isDefault="1">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" max="1" flag="62" seq="16" ref="0" bb="32" group="64" />
             </Parameter>
-            <Parameter id="S3Kk3JtnEEmB2etYRlStmA" name="Organ volume mouse" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.00158" displayUnit="l">
+            <Parameter id="SSdw_WGUUkut7Ds0SziYNQ" name="Density (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
-              <Info min="0" flag="54" seq="1" ref="0" bb="32" group="65" />
+              <Info min="0" flag="38" seq="1" ref="0" bb="32" group="21" />
             </Parameter>
-            <Parameter id="1lADDaObqk6g_j3JRyveDw" name="Density (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
+            <Parameter id="gZ8WguEuVUWqdH-l2Tjfpw" name="Fluid recirculation flow proportionality factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.96">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
-              <Info min="0" flag="38" seq="1" ref="0" bb="32" group="21" />
+              <Info min="0" flag="54" seq="1" ref="0" bb="32" group="27" />
             </Parameter>
-            <Parameter id="21tLT0CPIE-VKCuVjoQEOw" name="Lymph flow proportionality factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.000662">
+            <Parameter id="FV0nSrM5zE2uqeASf2tn3g" name="Lymph flow proportionality factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.000662">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" flag="54" seq="1" ref="0" bb="32" group="58" />
             </Parameter>
-            <Parameter id="xYgq01hKwEmwTxZE54EBlA" name="Peripheral blood flow fraction" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0">
+            <Parameter id="_eOzTzsMaEWoJYLW30iglA" name="Organ volume mouse" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.00158" displayUnit="l">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
-              <ValueOrigin id="46" source="Publication" description="Thiel C, Schneckener S, Krauss M, Ghallab A, Hofmann U, et al. A systematic evaluation of the use of physiologically based pharmacokinetic modeling for cross-species extrapolation. J Pharm Sci. 2015 Jan;104(1):191-206 https://doi.org/10.1002/jps.24214" />
-              <Info min="0" max="1" flag="122" seq="1" ref="0" bb="32" group="74" />
+              <Info min="0" flag="54" seq="1" ref="0" bb="32" group="65" />
             </Parameter>
-            <Parameter id="sZYcbFi9DUaS3bSzx-aJ6w" name="Fluid recirculation flow proportionality factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.96">
+            <Parameter id="s-WDuRNO6E-hJ9FjQanHIw" name="Peripheral blood flow fraction" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0">
               <Tags>
                 <Tag value="TissueOrgan" />
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                 </Parameter>
-                <Parameter id="_rqPyTtDL0KSQJcjbMM9zg" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_cell_2Pores" isDefault="1" displayUnit="l">
+                <Parameter id="WoVlkGIh8ka6NVFCVQBNvg" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_cell_2Pores" isDefault="1" displayUnit="l">
                   <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                   <Info min="0" flag="62" seq="5" ref="0" bb="2" group="125" />
                 </Parameter>
-                <Parameter id="YfpNdSTIvEmzRW63ZuT5tw" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7">
+                <Parameter id="aoQyUo7XE0-7WiJ5F9NX_Q" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7">
                   <Tags>
                     <Tag value="Bone" />
                   </Tags>
                   <ValueOrigin id="34" source="Publication" description="Toxicol In Vitro. 2008 Mar;22(2):457-67 https://doi.org/10.1016/j.tiv.2007.09.010" />
                   <Info min="0" max="14" flag="122" seq="17" ref="0" bb="32" group="83" />
                 </Parameter>
-                <Container id="riLwYNKkgk6N4nP54-xawg" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="AK00Z9VclkCxbg6I0YRnxw" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                   <Children>
-                    <Parameter id="5Qm-ntGF10aPuSxlS8xmag" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                    <Parameter id="IbTg7Zov6E2dfZMX4H5xbg" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                     </Parameter>
-                    <Parameter id="RAK5Zzo2h02sWii7xl7BuQ" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_bon" isDefault="1">
+                    <Parameter id="3UNliN_cjkWHIGENTGmOjA" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_bon" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                     </Parameter>
-                    <Parameter id="xVMq1K4SKk6FEmOFTJGEEA" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
+                    <Parameter id="tBNbfrzmPEitLmFxm174Rw" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
                       <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                     </Parameter>
                   </Children>
                 </Container>
               </Children>
             </Container>
-            <Container id="aJAbJim65USIdVbYSsUytw" name="Endosome" mode="Physical" containerType="Compartment">
+            <Container id="M_opIWAYvke3PQqeQDkFjA" name="Endosome" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="Bone" />
               </Tags>
               <Children>
-                <Parameter id="q7AvQklYkkCXOPpWbHf6-g" name="FcRn concentration in container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.FcRn_in_Container_Endosomal" isDefault="1" displayUnit="µmol/l">
+                <Parameter id="JuL8TUarjEm9GNzbKm5qpw" name="FcRn concentration in container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.FcRn_in_Container_Endosomal" isDefault="1" displayUnit="µmol/l">
                   <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                   <Info flag="52" seq="1" ref="0" bb="2" group="25" />
                 </Parameter>
-                <Parameter id="C2k1QydHQk2RMEUHgf4SQg" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                <Parameter id="XMYKGTs0dEqPP2io7gntPg" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
                   <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                 </Parameter>
-                <Parameter id="ETUWqtbCcEuTL99AzdTF8w" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_end_bon" isDefault="1" displayUnit="l">
+                <Parameter id="tulAwhxkH06CHMLIACQ37A" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_end_bon" isDefault="1" displayUnit="l">
                   <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                   <Info min="0" flag="122" seq="5" ref="0" bb="2" group="123" />
                 </Parameter>
-                <Container id="yx1-KjbQu0i7-3F1WZ5Pnw" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="bjTpLnRvZEyemOMxAB3NHQ" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                   <Children>
-                    <Parameter id="xLvM0-STW0mgp8rjigVEhg" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Endosomal" isDefault="1" displayUnit="µmol/l">
+                    <Parameter id="TX54rWOTV0y-EUlwiyuQwQ" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Endosomal" isDefault="1" displayUnit="µmol/l">
                       <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                       <Info flag="52" seq="1" ref="0" bb="2" group="25" />
                     </Parameter>
-                    <Parameter id="WjtEj6y-0EyG518QWkwOtA" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                    <Parameter id="ZEzuvC8VAEmlmOQJaWHoKA" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                     </Parameter>
-                    <Parameter id="-ahteD_-Vk-R2CPv5xr07Q" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                    <Parameter id="A0TheFvWR0ywYXQTYPeS4g" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
                       <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                     </Parameter>
-                    <Parameter id="Ggc2LlXfW0iqbjNvSacS_A" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
+                    <Parameter id="KHpzKA2g_k6kh81drlbrYA" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
                       <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                     </Parameter>
                   </Children>
@@ -965,503 +971,505 @@
             </Container>
           </Children>
         </Container>
-        <Container id="Yh8dNoILSE--3hDtmrZ9eQ" name="Gallbladder" mode="Physical" containerType="Organ">
+        <Container id="K-j3_tP-00WpCilFci4tTw" name="Gallbladder" mode="Physical" containerType="Organ">
           <Tags>
             <Tag value="Liver" />
           </Tags>
           <Children>
-            <Parameter id="EKlJXItLDUWfVWycLrwvKQ" name="Time to complete gallbladder refilling" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_GallbladderRefillTime" isDefault="1" displayUnit="min">
+            <Parameter id="n9e7XsMqOkS4I229ePlC6Q" name="Time to complete gallbladder refilling" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_GallbladderRefillTime" isDefault="1" displayUnit="min">
               <Info min="0" flag="122" seq="3" ref="0" bb="2" group="128" />
             </Parameter>
-            <Parameter id="VijJD5FMeUGbd3FRW9PI6A" name="Gallbladder emptying active" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0">
+            <Parameter id="ZOW68Ve6Tk2HNqGBzIXoWA" name="Gallbladder emptying active" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0">
               <Info min="0" max="1" flag="52" seq="4" ref="0" bb="2" group="128" />
             </Parameter>
-            <Parameter id="heYi4ra4vEi1liHgQhgKKA" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="l">
+            <Parameter id="XyroHDYB2UikuAnBUZYSfw" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="l">
               <Info min="0" flag="38" seq="666" ref="0" bb="2" group="65" />
             </Parameter>
-            <Parameter id="W-6PjIX4CEGYgJUMvyf_2A" name="Gallbladder ejection half-time" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="19.7" displayUnit="min">
+            <Parameter id="agCPHqnQA0CxYSAfrSdzzA" name="Gallbladder ejection half-time" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="19.7" displayUnit="min">
               <Tags>
                 <Tag value="Liver" />
               </Tags>
               <Info min="0" flag="122" seq="1" ref="0" bb="32" group="128" />
             </Parameter>
-            <Parameter id="d0ca3oqSr0WGCnHWSgE4bw" name="Gallbladder ejection fraction" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.65">
+            <Parameter id="X5XDGu6_fEaCbt8e68I40Q" name="Gallbladder ejection fraction" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.65">
               <Tags>
                 <Tag value="Liver" />
               </Tags>
               <Info min="0" max="1" flag="122" seq="2" ref="0" bb="32" group="128" />
             </Parameter>
-            <Container id="uPr4MHjKhUybdkDgr9Zv1g" name="MoleculeProperties" mode="Logical" containerType="Molecule" />
+            <Container id="5lxlgArjFUyWm0fxTMmbFw" name="MoleculeProperties" mode="Logical" containerType="Molecule" />
           </Children>
         </Container>
-        <Container id="e6smQjUAhE2HP-fHDgAiVg" name="Brain" mode="Logical" containerType="Organ">
+        <Container id="9LbFRaXU_0W9NfqRCp4eBQ" name="Brain" mode="Logical" containerType="Organ">
           <Tags>
             <Tag value="TissueOrgan" />
           </Tags>
           <Children>
-            <Parameter id="n4gMsYWy60mUvKLMobkmBQ" name="Fraction of endosomal uptake from plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_uptake_vas" isDefault="1">
+            <Parameter id="HF6oy2p1KUyLjbGBuTMD2w" name="Fraction of endosomal uptake from plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_uptake_vas" isDefault="1">
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
               <Info min="0" flag="54" seq="0" ref="0" bb="2" group="25" />
             </Parameter>
-            <Parameter id="_RCQRL5o1Ey7MRTWMCShJg" name="Fraction endosomal" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_endo" isDefault="1">
+            <Parameter id="gbbOAU8Ffky_hRWLsm_Y3g" name="Fraction endosomal" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_endo" isDefault="1">
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
               <Info min="0" max="1" flag="54" seq="1" ref="0" bb="2" group="29" />
             </Parameter>
-            <Parameter id="YIIYDxErwUu2nfNWqy1WMg" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
-              <Tags>
-                <Tag value="TissueOrgan" />
-              </Tags>
-              <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
-            </Parameter>
-            <Parameter id="RfpundVWDEqLUL82t0X6WA" name="Rate constant for recycling from endosomal space" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_K_rec" isDefault="1" displayUnit="1/min">
+            <Parameter id="K9E-wN1e_0C_xyUDTvU32g" name="Fraction recycled to plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_rec_vas" isDefault="1">
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
               <Info min="0" flag="54" seq="1" ref="0" bb="2" group="25" />
             </Parameter>
-            <Parameter id="9rxAEu6rhUuUqcfldaaFog" name="Rate constant for endosomal uptake" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_K_uptake" isDefault="1" displayUnit="1/min">
+            <Parameter id="wxPi33YA_kG13HXcioyqKQ" name="Rate constant for endosomal uptake" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_K_uptake" isDefault="1" displayUnit="1/min">
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
               <Info min="0" flag="54" seq="1" ref="0" bb="2" group="25" />
             </Parameter>
-            <Parameter id="SuFePahZWEuTO5GbSUNNFw" name="Fraction recycled to plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_rec_vas" isDefault="1">
+            <Parameter id="Wp-0jTpbCkC4wCh-d_d7xA" name="Rate constant for recycling from endosomal space" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_K_rec" isDefault="1" displayUnit="1/min">
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
               <Info min="0" flag="54" seq="1" ref="0" bb="2" group="25" />
             </Parameter>
-            <Parameter id="rdc8Z4s2F0K5AYNtRPXUfA" name="Volume (endothelium)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="VascularEndoVolume.VOLUME_VascularEndo_brn" isDefault="1" displayUnit="l">
+            <Parameter id="rKWZ-xDsjkCe-1L8nBh9nA" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
-              <Info min="0" flag="62" seq="6" ref="0" bb="32" group="127" />
+              <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
             </Parameter>
-            <Parameter id="DGTyYaNagUKzNXBv9EZ_2Q" name="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Lymph_flow_rate" isDefault="1" displayUnit="l/min">
+            <Parameter id="RoeOuNqZJ0yFj2goGx6O2A" name="Fluid recirculation flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate" isDefault="1" displayUnit="l/min">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-              <Info min="0" flag="122" seq="6" ref="0" bb="32" group="58" />
+              <Info min="0" flag="122" seq="6" ref="0" bb="32" group="27" />
             </Parameter>
-            <Parameter id="89YLdYlmP0C9La6-TPk1BQ" name="Fluid recirculation flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate" isDefault="1" displayUnit="l/min">
+            <Parameter id="sqT_tRjcU0aj6CPtY7ZtLw" name="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Lymph_flow_rate" isDefault="1" displayUnit="l/min">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-              <Info min="0" flag="122" seq="6" ref="0" bb="32" group="27" />
+              <Info min="0" flag="122" seq="6" ref="0" bb="32" group="58" />
+            </Parameter>
+            <Parameter id="5EAdJvs-nUmbBYl3zWzSQg" name="Volume (endothelium)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="VascularEndoVolume.VOLUME_VascularEndo_brn" isDefault="1" displayUnit="l">
+              <Tags>
+                <Tag value="TissueOrgan" />
+              </Tags>
+              <Info min="0" flag="62" seq="6" ref="0" bb="32" group="127" />
             </Parameter>
-            <Parameter id="ZC3szVXdbk6bG0oiJfytuw" name="Fraction intracellular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_f_cell" isDefault="1">
+            <Parameter id="9N29TkOeVUG3nybg-bZtxQ" name="Fraction intracellular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_f_cell" isDefault="1">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" max="1" flag="62" seq="19" ref="0" bb="32" group="64" />
             </Parameter>
-            <Parameter id="s8vcVp5qlE2WoPAn45Tz8A" name="Blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_from_Qspec" isDefault="1" displayUnit="l/min">
+            <Parameter id="hSbetgLANkeKRFzEfqQPzQ" name="Blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_from_Qspec" isDefault="1" displayUnit="l/min">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
-              <ValueOrigin id="48" description="TODO: Absolute from specific calculation" />
+              <ValueOrigin id="48" source="Other" description="Absolute value = specific value (i.e. value normalized to the volume of the organ) multiplied by the organ volume" />
               <Info min="0" flag="62" seq="22" ref="0" bb="32" group="5" />
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-                    <Parameter id="N29mDDpNPkKhVSa1A4P2lQ" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
-                      <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                    <Parameter id="APIxZ8Qhwk-NEidSa6Vkuw" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_brn" isDefault="1">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                     </Parameter>
-                    <Parameter id="Wqq-xTHf5kO_U8Yv1iBgYg" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Plasma_and_Interstitial" isDefault="1" displayUnit="µmol/l">
-                      <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-                      <Info flag="52" seq="1" ref="0" bb="2" group="25" />
+                    <Parameter id="OubHKHcIE0etXn68S5WUIQ" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
+                      <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                     </Parameter>
                   </Children>
                 </Container>
               </Children>
             </Container>
-            <Container id="qoPlFrfmhEaQ7ran3xzriQ" name="Intracellular" mode="Physical" containerType="Compartment">
+            <Container id="-SetkLXoakGgu8wV-vcpXg" name="Intracellular" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="Brain" />
               </Tags>
               <Children>
-                <Parameter id="KE-QfKAbFkmnH-x_1pbQXg" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" isDefault="1" displayUnit="l">
+                <Parameter id="icwtFnikrUWiEdxaiEf_0Q" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" isDefault="1" displayUnit="l">
                   <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                 </Parameter>
-                <Parameter id="mMO2_nJnrkuXvTUWk0j8VQ" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_cell_2Pores" isDefault="1" displayUnit="l">
+                <Parameter id="VN0TfvjKlkerhmnL040URA" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_cell_2Pores" isDefault="1" displayUnit="l">
                   <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                   <Info min="0" flag="62" seq="6" ref="0" bb="2" group="125" />
                 </Parameter>
-                <Parameter id="dZb4fr9wsEacvuzJ4aqn5Q" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.1">
+                <Parameter id="A_2Xe84GuEaCvHJTJy8lEQ" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.1">
                   <Tags>
                     <Tag value="Brain" />
                   </Tags>
                   <ValueOrigin id="34" source="Publication" description="Toxicol In Vitro. 2008 Mar;22(2):457-67 https://doi.org/10.1016/j.tiv.2007.09.010" />
                   <Info min="0" max="14" flag="122" seq="20" ref="0" bb="32" group="83" />
                 </Parameter>
-                <Container id="Ux-GZHbQMEeGmhTxpBUhPg" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="1gA9dyxIhUikgk6arA8XIw" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                   <Children>
-                    <Parameter id="Y4rqUGbAZEGHUF9OvrNM3A" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                    <Parameter id="Rfbp5evMa0yI9f4AgraufA" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                     </Parameter>
-                    <Parameter id="stKLNzQ72Ei2Ceijoc4PdA" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_brn" isDefault="1">
+                    <Parameter id="316_0hvAhUeBVSr6iwEEGA" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_brn" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                     </Parameter>
-                    <Parameter id="eRIUeEZEmkmWvceNOB2qqw" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
+                    <Parameter id="dtWHoPGY8EGv3Hqh_aBdZg" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
                       <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                     </Parameter>
                   </Children>
                 </Container>
               </Children>
             </Container>
-            <Container id="CC-B3cUCDk6CNAJ95txMFQ" name="Endosome" mode="Physical" containerType="Compartment">
+            <Container id="RUbr4e4oDUWZTVZF-N710A" name="Endosome" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="Brain" />
               </Tags>
               <Children>
-                <Parameter id="Wqqc0GIWTkCEr00LvNyHjg" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
-                  <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
-                </Parameter>
-                <Parameter id="kkxuih5BeE-sx2DVy543fQ" name="FcRn concentration in container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.FcRn_in_Container_Endosomal" isDefault="1" displayUnit="µmol/l">
+                <Parameter id="SkK0mCLQekGJqxcNrXSxKQ" name="FcRn concentration in container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.FcRn_in_Container_Endosomal" isDefault="1" displayUnit="µmol/l">
                   <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                   <Info flag="52" seq="1" ref="0" bb="2" group="25" />
                 </Parameter>
-                <Parameter id="0EwhG933k0SgfZRzZ0lPqQ" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_end_brn" isDefault="1" displayUnit="l">
+                <Parameter id="H0SGpkfZe0W63PuMOcwsaA" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                  <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                </Parameter>
+                <Parameter id="1wzvTcKwZEaF6wP7ZP5p1w" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_end_brn" isDefault="1" displayUnit="l">
                   <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                   <Info min="0" flag="122" seq="6" ref="0" bb="2" group="123" />
                 </Parameter>
-                <Container id="LdNYd7z1ykipJLWEDVb3OA" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="SKe2iUVDbk2qZXzuyOew5A" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                   <Children>
-                    <Parameter id="2IeSqz_AE0y2ir3UC7Uv-Q" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Endosomal" isDefault="1" displayUnit="µmol/l">
+                    <Parameter id="R4aHp19AMEWb4bNFJyTB0A" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Endosomal" isDefault="1" displayUnit="µmol/l">
                       <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                       <Info flag="52" seq="1" ref="0" bb="2" group="25" />
                     </Parameter>
-                    <Parameter id="zr5mQgq4jEO1xhtOVHbtuQ" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                    <Parameter id="ROff-8WVrE2gjtsiFlMJew" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                     </Parameter>
-                    <Parameter id="6S6iKEgQCUS5QTpTqP--iA" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                    <Parameter id="SoDBSY6KoUK-nY0CGYSJRA" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
                       <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                     </Parameter>
-                    <Parameter id="tvMfR6xLwk6lbIx0m11NBA" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
+                    <Parameter id="r2lLDvDZ_ka89K-_-apTdQ" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
                       <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                     </Parameter>
                   </Children>
@@ -1470,247 +1478,248 @@
             </Container>
           </Children>
         </Container>
-        <Container id="lYjUUXbLKUuUmljEME9kiQ" name="Fat" mode="Logical" containerType="Organ">
+        <Container id="o6CkEyd2y06ERLZEfZ_pMg" name="Fat" mode="Logical" containerType="Organ">
           <Tags>
             <Tag value="TissueOrgan" />
           </Tags>
           <Children>
-            <Parameter id="Ea9Bw1d-Gk-_zZNEXMz5Cg" name="Fraction of endosomal uptake from plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_uptake_vas" isDefault="1">
+            <Parameter id="XSw0Srlk50eOPwF1cVyHKg" name="Fraction of endosomal uptake from plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_uptake_vas" isDefault="1">
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
               <Info min="0" flag="54" seq="0" ref="0" bb="2" group="25" />
             </Parameter>
-            <Parameter id="hIrJlrJf-0Ox1YFVHch5_Q" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
-              <Tags>
-                <Tag value="TissueOrgan" />
-              </Tags>
-              <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
-            </Parameter>
-            <Parameter id="8VWgu2ZPQEKSMOJysf6ZDQ" name="Rate constant for recycling from endosomal space" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_K_rec" isDefault="1" displayUnit="1/min">
+            <Parameter id="k5TCYTjac0uJG0G5QJvTxQ" name="Fraction endosomal" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_endo" isDefault="1">
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-              <Info min="0" flag="54" seq="1" ref="0" bb="2" group="25" />
+              <Info min="0" max="1" flag="54" seq="1" ref="0" bb="2" group="29" />
             </Parameter>
-            <Parameter id="brh6LnFL7EeNck073SAxUA" name="Fraction recycled to plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_rec_vas" isDefault="1">
+            <Parameter id="TAH4nT_yh0i-nAqyIr0qbw" name="Fraction recycled to plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_rec_vas" isDefault="1">
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
               <Info min="0" flag="54" seq="1" ref="0" bb="2" group="25" />
             </Parameter>
-            <Parameter id="3igOj0p2q06_2XkshHl9Gg" name="Fraction endosomal" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_endo" isDefault="1">
+            <Parameter id="OQ-oMdKEAkufFc-uflqlNQ" name="Rate constant for endosomal uptake" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_K_uptake" isDefault="1" displayUnit="1/min">
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-              <Info min="0" max="1" flag="54" seq="1" ref="0" bb="2" group="29" />
+              <Info min="0" flag="54" seq="1" ref="0" bb="2" group="25" />
             </Parameter>
-            <Parameter id="pOz7w_xto0WG5Y_9vv5xow" name="Rate constant for endosomal uptake" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_K_uptake" isDefault="1" displayUnit="1/min">
+            <Parameter id="iDkcXlO1kka_30YJanuTow" name="Rate constant for recycling from endosomal space" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_K_rec" isDefault="1" displayUnit="1/min">
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
               <Info min="0" flag="54" seq="1" ref="0" bb="2" group="25" />
             </Parameter>
-            <Parameter id="XM6VMZa_8UmCToqva0nJLg" name="Volume (endothelium)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="VascularEndoVolume.VOLUME_VascularEndo_fat" isDefault="1" displayUnit="l">
+            <Parameter id="iPyKP_mJl0mdlF0XSPxi9A" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
-              <Info min="0" flag="62" seq="7" ref="0" bb="32" group="127" />
+              <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
             </Parameter>
-            <Parameter id="rCBMYrIdu0qCNwSJCYVcbw" name="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Lymph_flow_rate" isDefault="1" displayUnit="l/min">
+            <Parameter id="ljWRE1PhLUC2Wiu83RCYfA" name="Fluid recirculation flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate" isDefault="1" displayUnit="l/min">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-              <Info min="0" flag="122" seq="7" ref="0" bb="32" group="58" />
+              <Info min="0" flag="122" seq="7" ref="0" bb="32" group="27" />
             </Parameter>
-            <Parameter id="FxEcfCa290GQPUQgSCer3w" name="Fluid recirculation flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate" isDefault="1" displayUnit="l/min">
+            <Parameter id="fMY252sqfU2dwByo-ka0FA" name="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Lymph_flow_rate" isDefault="1" displayUnit="l/min">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-              <Info min="0" flag="122" seq="7" ref="0" bb="32" group="27" />
+              <Info min="0" flag="122" seq="7" ref="0" bb="32" group="58" />
+            </Parameter>
+            <Parameter id="_5hKSVlPD0-bmJ_RX2OS7A" name="Volume (endothelium)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="VascularEndoVolume.VOLUME_VascularEndo_fat" isDefault="1" displayUnit="l">
+              <Tags>
+                <Tag value="TissueOrgan" />
+              </Tags>
+              <Info min="0" flag="62" seq="7" ref="0" bb="32" group="127" />
             </Parameter>
-            <Parameter id="qGVVeq7YH0q9bpFGw42_gg" name="Fraction intracellular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_f_cell" isDefault="1">
+            <Parameter id="MC8aXnv-FUuUITvm17Jx5w" name="Fraction intracellular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_f_cell" isDefault="1">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" max="1" flag="62" seq="22" ref="0" bb="32" group="64" />
             </Parameter>
-            <Parameter id="HRgTi6TA8km24paPmG774w" name="Blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_from_Qspec" isDefault="1" displayUnit="l/min">
+            <Parameter id="0ue_x-bXZUusO1HHtZwRRQ" name="Blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_from_Qspec" isDefault="1" displayUnit="l/min">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
-              <ValueOrigin id="48" description="TODO: Absolute from specific calculation" />
+              <ValueOrigin id="48" source="Other" description="Absolute value = specific value (i.e. value normalized to the volume of the organ) multiplied by the organ volume" />
               <Info min="0" flag="62" seq="42" ref="0" bb="32" group="5" />
             </Parameter>
-            <Parameter id="z1sL_TiDeUu91susSFAYUA" name="Organ volume mouse" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.001" displayUnit="l">
+            <Parameter id="jjHDmfpN4kOJ8LdrzSM8vw" name="Density (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
-              <Info min="0" flag="54" seq="1" ref="0" bb="32" group="65" />
+              <Info min="0" flag="38" seq="1" ref="0" bb="32" group="21" />
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-                <Parameter id="8KTYe0CrGkeV6DXU8qr_Iw" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.002">
+                <Parameter id="7n3nt8g9q0GtNAo1pmtU1g" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.002">
                   <Info min="0" max="1" flag="50" seq="1" ref="0" bb="32" group="86" />
                 </Parameter>
               </Children>
@@ -1719,26 +1728,27 @@
               </Tags>
               <Info min="0" max="1" flag="122" seq="22" ref="0" bb="32" group="86" />
             </DistributedParameter>
-            <DistributedParameter id="61atO89KDkOuQvBW07a8vQ" name="Fraction interstitial" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Qh8aNf9t-U-g49-hQS2Aow" mode="Logical" isDefault="1">
+            <DistributedParameter id="2JUboQ5vA0u3rUjfi91TVw" name="Fraction interstitial" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="hPUpKBXTFE-M3jjQsRLakg" mode="Logical" isDefault="1">
               <Children>
-                <Parameter id="5fEbJnvEtUqZWLka0bweIQ" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                <Parameter id="NPTorskjyEu_tRJwy2d10A" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
                   <Info min="0" flag="18" seq="1" ref="0" bb="32" group="64" />
                 </Parameter>
-                <Parameter id="d3ia86UVh0mi2u4i9uaCVg" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.16">
+                <Parameter id="zRiSrHENiE69tC5WaysVRg" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.16">
                   <Info min="0" max="1" flag="50" seq="1" ref="0" bb="32" group="64" />
                 </Parameter>
               </Children>
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
+              <ValueOrigin id="40" source="Publication" description="Edginton, A.N., Schmitt, W. &amp; Willmann, S. Clin Pharmacokinet (2006) 45: 1013. https://doi.org/10.2165/00003088-200645100-00005" />
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             </DistributedParameter>
-            <DistributedParameter id="H3TxFGNqjEiRKNjTshslhw" name="Vf (water)" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ZgCzIwyyxk6lJKS-qHPohA" mode="Logical" isDefault="1">
+            <DistributedParameter id="BGeyTpFr40OF_E9IW8msSw" name="Vf (water)" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="i80_ymzRe063T1ry4QGADQ" mode="Logical" isDefault="1">
               <Children>
-                <Parameter id="L00IO7hWM0iFMf2PkLrUNw" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                <Parameter id="vRR0kFs1jEG1JwXIVUQ2rw" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
                   <Info min="0" flag="18" seq="1" ref="0" bb="32" group="85" />
                 </Parameter>
-                <Parameter id="2hhlQ-K_eEW1pbF_JhNRww" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.15">
+                <Parameter id="pRyCSYrCtUW1oVgfGdcf6w" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.15">
                   <Info min="0" max="1" flag="50" seq="1" ref="0" bb="32" group="85" />
                 </Parameter>
               </Children>
@@ -1748,12 +1758,12 @@
               <ValueOrigin id="40" source="Publication" description="Edginton, A.N., Schmitt, W. &amp; Willmann, S. Clin Pharmacokinet (2006) 45: 1013. https://doi.org/10.2165/00003088-200645100-00005" />
               <Info min="0" max="1" flag="122" seq="23" ref="0" bb="32" group="85" />
             </DistributedParameter>
-            <DistributedParameter id="w7XyEwmIuE-ms95jlJW5TQ" name="Vf (water)-PT" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="neeV119lKEiyjXt9GbNk2A" mode="Logical" isDefault="1">
+            <DistributedParameter id="Z_vENtzln0O8rE2Tg1n80A" name="Vf (water)-PT" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="vf1lKQQsWkiZvmMS2VuNYA" mode="Logical" isDefault="1">
               <Children>
-                <Parameter id="bOieTRXxwUOkqRrmWwrFag" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                <Parameter id="ZCnNr2jT1E6Y16Eb1Rwv9A" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
                   <Info min="0" flag="18" seq="1" ref="0" bb="32" group="86" />
                 </Parameter>
-                <Parameter id="EtveyfnKeEqeLGIdoijVtQ" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.18">
+                <Parameter id="AsOmt9Xs8Uyv9UFEWqMMoQ" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.18">
                   <Info min="0" max="1" flag="50" seq="1" ref="0" bb="32" group="86" />
                 </Parameter>
               </Children>
@@ -1762,12 +1772,12 @@
               </Tags>
               <Info min="0" max="1" flag="122" seq="23" ref="0" bb="32" group="86" />
             </DistributedParameter>
-            <DistributedParameter id="9LQ5JvPn5UyKh7YAP9g-mg" name="Vf (neutral lipid)-RR" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BhYy8LF3Uk-y8HX46E4l1A" mode="Logical" isDefault="1">
+            <DistributedParameter id="yf1HaOINIkiQ7FV-5igPZQ" name="Vf (neutral lipid)-RR" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="nkn0V2M9eUadS5whRRdnzQ" mode="Logical" isDefault="1">
               <Children>
-                <Parameter id="56gDO28kok-feEXMQKcoVQ" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                <Parameter id="wFp2UjMYMEKpkBQmq-hgBA" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
                   <Info min="0" flag="18" seq="1" ref="0" bb="32" group="92" />
                 </Parameter>
-                <Parameter id="-bmYbOYs8keP0qVXxQNWCg" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.853">
+                <Parameter id="GJ_RaDOuEEOqLzrZzD4dBA" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.853">
                   <Info min="0" max="1" flag="50" seq="1" ref="0" bb="32" group="92" />
                 </Parameter>
               </Children>
@@ -1776,12 +1786,12 @@
               </Tags>
               <Info min="0" max="1" flag="122" seq="35" ref="0" bb="32" group="92" />
             </DistributedParameter>
-            <DistributedParameter id="HcwvSDsxUEWHveWJnd10Qg" name="Vf (neutral lipid)-WS" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="X1yeRyZrN0O4AKAlrlreyg" mode="Logical" isDefault="1">
+            <DistributedParameter id="rWP-GPF9N0ybCftcGPAKlw" name="Vf (neutral lipid)-WS" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="s1qSj7NSwUi4S0gRmK3cjQ" mode="Logical" isDefault="1">
               <Children>
-                <Parameter id="zndza1cTXkuk543R-CkuBw" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                <Parameter id="p5vfn7oyMk6U8m1EaPTw5A" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
                   <Info min="0" flag="18" seq="1" ref="0" bb="32" group="95" />
                 </Parameter>
-                <Parameter id="gP1DwOA4SUKhWyRqwx2NMw" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.92">
+                <Parameter id="Bi13_GBpH0-27cp3gFfwcQ" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.92">
                   <Info min="0" max="1" flag="50" seq="1" ref="0" bb="32" group="95" />
                 </Parameter>
               </Children>
@@ -1790,12 +1800,12 @@
               </Tags>
               <Info min="0" max="1" flag="122" seq="35" ref="0" bb="32" group="95" />
             </DistributedParameter>
-            <DistributedParameter id="sKxtEWLukkCXrMU5--hO6A" name="Vf (neutral phospholipid)-RR" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="dN_TditVFESTMjSrfMS7xQ" mode="Logical" isDefault="1">
+            <DistributedParameter id="YmBZJ_V__E6pdm-5MqNBag" name="Vf (neutral phospholipid)-RR" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="rRfYgqFbbUCLUH3x1VAiCg" mode="Logical" isDefault="1">
               <Children>
-                <Parameter id="--CKbmtbVkamDWDLvovFqA" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                <Parameter id="Z-UFxMvgI0qxjQH3BobYBw" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
                   <Info min="0" flag="18" seq="1" ref="0" bb="32" group="92" />
                 </Parameter>
-                <Parameter id="k3JPj5_rLkueqon_7iJ9Ig" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0016">
+                <Parameter id="N2pA8M8JBE-5EFZgiDbqsg" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0016">
                   <Info min="0" max="1" flag="50" seq="1" ref="0" bb="32" group="92" />
                 </Parameter>
               </Children>
@@ -1804,12 +1814,12 @@
               </Tags>
               <Info min="0" max="1" flag="122" seq="36" ref="0" bb="32" group="92" />
             </DistributedParameter>
-            <DistributedParameter id="4WmFDSEzGUuvQq7Jfinscg" name="Vf (neutral phospholipid, plasma)-WS" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Rz7xv73jcUy5JGVPwGXlIw" mode="Logical" isDefault="1">
+            <DistributedParameter id="qmeGvtSnA0uwSUtTqsZp6Q" name="Vf (neutral phospholipid, plasma)-WS" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="FuWkZPIMRkS6TGZdT-8uxA" mode="Logical" isDefault="1">
               <Children>
-                <Parameter id="k1O2X2wD1kyT-fIiTKbWYg" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                <Parameter id="zks05Eoy5EenTHk4XZCvnw" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
                   <Info min="0" flag="18" seq="1" ref="0" bb="32" group="95" />
                 </Parameter>
-                <Parameter id="zvYMAOhOPUurinPJTcSQzA" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.002024">
+                <Parameter id="hCGmrnMB_0OmLgiIB1jNEg" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.002024">
                   <Info min="0" max="1" flag="50" seq="1" ref="0" bb="32" group="95" />
                 </Parameter>
               </Children>
@@ -1818,12 +1828,12 @@
               </Tags>
               <Info min="0" max="1" flag="122" seq="36" ref="0" bb="32" group="95" />
             </DistributedParameter>
-            <DistributedParameter id="JStmXP6jsE-K6fRhxhP7Rw" name="Vf (extracellular water)-RR" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="fxEUPmt3DkyoLMDkY4YGhA" mode="Logical" isDefault="1">
+            <DistributedParameter id="cfZ0V0M0hkSAa8-FwRycow" name="Vf (extracellular water)-RR" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="uZ6O-T2Hg0yKSXVAuv1wJQ" mode="Logical" isDefault="1">
               <Children>
-                <Parameter id="Wz7Fe3rmf0SwaBWstfKnRQ" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                <Parameter id="3Tz7h6GAcUmoY0K9n37vmw" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
                   <Info min="0" flag="18" seq="1" ref="0" bb="32" group="92" />
                 </Parameter>
-                <Parameter id="yapkIlq6UE6Xtk6eM0zLJw" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.135">
+                <Parameter id="Lo9hMuNvQk-Smjxs5vLyJw" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.135">
                   <Info min="0" max="1" flag="50" seq="1" ref="0" bb="32" group="92" />
                 </Parameter>
               </Children>
@@ -1832,12 +1842,12 @@
               </Tags>
               <Info min="0" max="1" flag="122" seq="37" ref="0" bb="32" group="92" />
             </DistributedParameter>
-            <DistributedParameter id="X2uO7ZgN60itO0NxCIvJZg" name="Vf (intracellular water)-RR" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="yB3F3wURqEKV_n2oi481kA" mode="Logical" isDefault="1">
+            <DistributedParameter id="a6kw4v4EhkmSdzdme1bYAA" name="Vf (intracellular water)-RR" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="8Qu75lh550ufW8bY-O8fgg" mode="Logical" isDefault="1">
               <Children>
-                <Parameter id="GS41s4srJUCi4Jll0j_Wpg" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                <Parameter id="A2Xu-O1Tnkq9FVoyFU4KpQ" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
                   <Info min="0" flag="18" seq="1" ref="0" bb="32" group="92" />
                 </Parameter>
-                <Parameter id="sOaYU_1_g0OHBBEUy9XRKg" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.00899999999999998">
+                <Parameter id="bkzbhCJeJkylMtGFYaerow" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.00899999999999998">
                   <Info min="0" max="1" flag="50" seq="1" ref="0" bb="32" group="92" />
                 </Parameter>
               </Children>
@@ -1846,12 +1856,12 @@
               </Tags>
               <Info min="0" max="1" flag="122" seq="38" ref="0" bb="32" group="92" />
             </DistributedParameter>
-            <DistributedParameter id="-n6pwljqoUGqkQTJAoE5Fw" name="Vf (water)-WS" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="EsBXTfiUk0-p6uyUJ_PQ2w" mode="Logical" isDefault="1">
+            <DistributedParameter id="oiE-eNARHUOtRL5imo3uqw" name="Vf (water)-WS" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="0x8c3avJv0iM0Se29gdD-A" mode="Logical" isDefault="1">
               <Children>
-                <Parameter id="8sfpwlpTqkuUzbTyMK9NQQ" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                <Parameter id="ai9pxj9BSUKIJkQ7B-Jycg" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
                   <Info min="0" flag="18" seq="1" ref="0" bb="32" group="95" />
                 </Parameter>
-                <Parameter id="kae_jL1zGUa9IP8gZRLhAA" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.03">
+                <Parameter id="JPXnmY7qgkiC4joIQvgGoA" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.03">
                   <Info min="0" max="1" flag="50" seq="1" ref="0" bb="32" group="95" />
                 </Parameter>
               </Children>
@@ -1860,190 +1870,191 @@
               </Tags>
               <Info min="0" max="1" flag="122" seq="38" ref="0" bb="32" group="95" />
             </DistributedParameter>
-            <DistributedParameter id="0kmIkQSZ0EGzhVVzqc8mmg" name="Specific blood flow rate" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" formula="tsPZS3WX0026qLmLXJSy4A" mode="Logical" isDefault="1" displayUnit="ml/min/100g organ">
+            <DistributedParameter id="MdDMG2lRRU-iAFyQb2e3EQ" name="Specific blood flow rate" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" formula="I2FWLu_G30e8eD0S-BRWJQ" mode="Logical" isDefault="1" displayUnit="ml/min/100g organ">
               <Children>
-                <Parameter id="0hU7wnuCREmYvnsrT8ggOQ" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5" displayUnit="ml/min/100g organ">
+                <Parameter id="mwkoSJQ3kUO1H7KPWv_Wug" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5" displayUnit="ml/min/100g organ">
                   <Info min="0" flag="18" seq="1" ref="0" bb="32" group="5" />
                 </Parameter>
-                <Parameter id="oorw3FrnFUSRVe3BKifLcg" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.02184" displayUnit="ml/min/100g organ">
+                <Parameter id="quHmzb8DG0q6MXLw-ChjRQ" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.02184" displayUnit="ml/min/100g organ">
                   <Info min="0" flag="50" seq="1" ref="0" bb="32" group="5" />
                 </Parameter>
-                <Parameter id="rHBg53yJ1kiYfN2Sq85Ngw" name="Deviation" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.001092" displayUnit="ml/min/100g organ">
+                <Parameter id="U4M7-SpJ7USZAE7CN5gwIw" name="Deviation" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.001092" displayUnit="ml/min/100g organ">
                   <Info min="0" flag="18" seq="1" ref="0" bb="32" group="5" />
                 </Parameter>
               </Children>
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
+              <ValueOrigin id="40" source="Publication" description="Edginton, A.N., Schmitt, W. &amp; Willmann, S. Clin Pharmacokinet (2006) 45: 1013. https://doi.org/10.2165/00003088-200645100-00005" />
               <Info min="0" flag="122" seq="41" ref="0" bb="32" group="5" />
             </DistributedParameter>
-            <Container id="kr-PEFddzEibScWFXl8A1Q" name="Plasma" mode="Physical" containerType="Compartment">
+            <Container id="C5HmC00ryECjS1x2r0r1xw" name="Plasma" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="Fat" />
               </Tags>
               <Children>
-                <Parameter id="yaZWWqfhxEWf-4RKdMHL-w" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
-                  <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
-                </Parameter>
-                <Parameter id="vhrsglYTak6v_gcsm-GaLg" name="FcRn concentration in container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.FcRn_in_Container_Plasma" isDefault="1" displayUnit="µmol/l">
+                <Parameter id="hwTwneBY2kaAWUprh4KZBw" name="FcRn concentration in container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.FcRn_in_Container_Plasma" isDefault="1" displayUnit="µmol/l">
                   <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                   <Info flag="52" seq="1" ref="0" bb="2" group="25" />
                 </Parameter>
-                <Parameter id="WrhDJUOsPEiBTlGDHewhqQ" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_pls_2Pores" isDefault="1" displayUnit="l">
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-                    <Parameter id="2yKI7dd5xkOkAfROWS41aQ" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                    <Parameter id="6sopJdM1IEeikL3B0-hXmw" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                     </Parameter>
-                    <Parameter id="81MTcZjy6EauDpSvNb3CAQ" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                    <Parameter id="x6v_-llX30-1ZYngXRI8UQ" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
                       <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                     </Parameter>
-                    <Parameter id="X7zOn8HP4ESQ_2-7iBNERg" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
+                    <Parameter id="gccPDZ6NMU-s4mtJXUDfmA" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
                       <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                     </Parameter>
                   </Children>
@@ -2052,470 +2063,472 @@
             </Container>
           </Children>
         </Container>
-        <Container id="YWFDfwqGIEq8U668XGWUqQ" name="Gonads" mode="Logical" containerType="Organ">
+        <Container id="NxCKAvMxVkWdgpL8NACOUQ" name="Gonads" mode="Logical" containerType="Organ">
           <Tags>
             <Tag value="TissueOrgan" />
           </Tags>
           <Children>
-            <Parameter id="4cpT-udrJk-qIjr38pVHtw" name="Fraction of endosomal uptake from plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_uptake_vas" isDefault="1">
+            <Parameter id="PmysTfuV2UeLlWL4xizjzw" name="Fraction of endosomal uptake from plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_uptake_vas" isDefault="1">
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
               <Info min="0" flag="54" seq="0" ref="0" bb="2" group="25" />
             </Parameter>
-            <Parameter id="8aUohH2el0qpCYm3mVMHHA" name="Fraction endosomal" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_endo" isDefault="1">
+            <Parameter id="ObCvDXoukkO2tW3P7w2Teg" name="Fraction endosomal" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_endo" isDefault="1">
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
               <Info min="0" max="1" flag="54" seq="1" ref="0" bb="2" group="29" />
             </Parameter>
-            <Parameter id="1-DpwWv3FEa7SXXHqVNmpQ" name="Rate constant for endosomal uptake" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_K_uptake" isDefault="1" displayUnit="1/min">
+            <Parameter id="PlaaGxn2DkmGHV38pPvzyw" name="Fraction recycled to plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_rec_vas" isDefault="1">
+              <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+              <Info min="0" flag="54" seq="1" ref="0" bb="2" group="25" />
+            </Parameter>
+            <Parameter id="LZuVFopDjkKQhab9r4Ye2Q" name="Rate constant for endosomal uptake" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_K_uptake" isDefault="1" displayUnit="1/min">
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
               <Info min="0" flag="54" seq="1" ref="0" bb="2" group="25" />
             </Parameter>
-            <Parameter id="X5X-cte6mEeqjCI6d0o6aw" name="Fraction recycled to plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_rec_vas" isDefault="1">
+            <Parameter id="zEosqvV5Ek2beFErv7lwIQ" name="Rate constant for recycling from endosomal space" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_K_rec" isDefault="1" displayUnit="1/min">
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
               <Info min="0" flag="54" seq="1" ref="0" bb="2" group="25" />
             </Parameter>
-            <Parameter id="Ifc_6zJOUkCA-906aNba2A" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
+            <Parameter id="kHZg0mwv10Wi1SpNg12GXA" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
             </Parameter>
-            <Parameter id="dMbJJk1W9Uu5EnqF0VEmlA" name="Rate constant for recycling from endosomal space" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_K_rec" isDefault="1" displayUnit="1/min">
-              <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-              <Info min="0" flag="54" seq="1" ref="0" bb="2" group="25" />
-            </Parameter>
-            <Parameter id="e1plA89lwke4FD3IWeRTGw" name="Volume (endothelium)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="VascularEndoVolume.VOLUME_VascularEndo_tes" isDefault="1" displayUnit="l">
+            <Parameter id="h4t1UJcLLkGAt_zyUxcl9g" name="Fluid recirculation flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate" isDefault="1" displayUnit="l/min">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
-              <Info min="0" flag="62" seq="10" ref="0" bb="32" group="127" />
+              <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+              <Info min="0" flag="122" seq="10" ref="0" bb="32" group="27" />
             </Parameter>
-            <Parameter id="rm_6Xl2J_Em9ct_N9aqMJg" name="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Lymph_flow_rate" isDefault="1" displayUnit="l/min">
+            <Parameter id="ukf_4CFWNEqCGHoF8UrV-Q" name="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Lymph_flow_rate" isDefault="1" displayUnit="l/min">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
               <Info min="0" flag="122" seq="10" ref="0" bb="32" group="58" />
             </Parameter>
-            <Parameter id="B_v4aFeRtEStLtt5jYp0GA" name="Fluid recirculation flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate" isDefault="1" displayUnit="l/min">
+            <Parameter id="LkyA-HNhHEuSnpEFO7DJ2w" name="Volume (endothelium)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="VascularEndoVolume.VOLUME_VascularEndo_tes" isDefault="1" displayUnit="l">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
-              <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-              <Info min="0" flag="122" seq="10" ref="0" bb="32" group="27" />
+              <Info min="0" flag="62" seq="10" ref="0" bb="32" group="127" />
             </Parameter>
-            <Parameter id="KrTY1YFZ5UaGdywD9omUeQ" name="Fraction intracellular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_f_cell" isDefault="1">
+            <Parameter id="lVJ6PINz-UOPjm6xBatDDA" name="Fraction intracellular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_f_cell" isDefault="1">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" max="1" flag="62" seq="31" ref="0" bb="32" group="64" />
             </Parameter>
-            <Parameter id="BlCEEkGEKE6EMlXYHS-7qA" name="Blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_from_Qspec" isDefault="1" displayUnit="l/min">
+            <Parameter id="3qKM8dqTLEq_QSXC9bUJAQ" name="Blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_from_Qspec" isDefault="1" displayUnit="l/min">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
-              <ValueOrigin id="48" description="TODO: Absolute from specific calculation" />
+              <ValueOrigin id="48" source="Other" description="Absolute value = specific value (i.e. value normalized to the volume of the organ) multiplied by the organ volume" />
               <Info min="0" flag="62" seq="62" ref="0" bb="32" group="5" />
             </Parameter>
-            <Parameter id="iHvJzzuQckmNG4bxB6-cdg" name="Density (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
+            <Parameter id="SX1dBNEKjkaSJ0M98UqjDQ" name="Density (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" flag="38" seq="1" ref="0" bb="32" group="21" />
             </Parameter>
-            <Parameter id="qBxQYK4f5UyInUz3QSH9Hg" name="Fluid recirculation flow proportionality factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.96">
+            <Parameter id="7WWMClEvLEO_t1wWh6Rkmg" name="Fluid recirculation flow proportionality factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.96">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" flag="54" seq="1" ref="0" bb="32" group="27" />
             </Parameter>
-            <Parameter id="bMO0xKsQXEiLwMzcv9MSDw" name="Lymph flow proportionality factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0111">
+            <Parameter id="tFpn3svPh0GyLvF050EgDg" name="Lymph flow proportionality factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0111">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" flag="54" seq="1" ref="0" bb="32" group="58" />
             </Parameter>
-            <Parameter id="JIqBsP6iq0C5lnDgbLCX8A" name="Organ volume mouse" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.00025" displayUnit="l">
+            <Parameter id="6GfLg3WNVU67cH4kkLzSjw" name="Organ volume mouse" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.00025" displayUnit="l">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" flag="54" seq="1" ref="0" bb="32" group="65" />
             </Parameter>
-            <Parameter id="6ZBP281ZCUuavZaRpEp9MA" name="Allometric scale factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.75">
+            <Parameter id="dHXaS1T9ukS3Bb71PbfWaQ" name="Allometric scale factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.75">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0.75" max="0.75" flag="54" seq="1" ref="0" bb="32" group="2" />
             </Parameter>
-            <Parameter id="5ABCJMGh2U6pOHnPMrszEQ" name="Fraction of blood for sampling" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+            <Parameter id="84IDwlkp6k6Flb08tKgtAg" name="Fraction of blood for sampling" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" max="1" flag="54" seq="1" ref="0" bb="32" group="94" />
             </Parameter>
-            <Parameter id="qNxuiaUSYUOupk0woLCF9A" name="Radius (large pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.5E-07" displayUnit="µm">
+            <Parameter id="Ekjbfz4qjkCTz_lHk-mZ_Q" name="Flow fraction via large pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.05">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-              <Info min="0" flag="122" seq="10" ref="0" bb="32" group="55" />
+              <Info min="0" max="1" flag="122" seq="10" ref="0" bb="32" group="114" />
             </Parameter>
-            <Parameter id="Qs7mo9spxkmDBnsO3A8JsQ" name="Hydraulic conductivity" icon="Parameter" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="9E-12" displayUnit="ml/min/N">
+            <Parameter id="K8fB7pliekmc1eABNM-Z0Q" name="Hydraulic conductivity" icon="Parameter" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="9E-12" displayUnit="ml/min/N">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
               <Info min="0" flag="122" seq="10" ref="0" bb="32" group="115" />
             </Parameter>
-            <Parameter id="wK59HYvieUipYYI_JQP-OA" name="Flow fraction via large pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.05">
+            <Parameter id="IgQ-RHSm4UWbyIhctw0jWQ" name="Radius (large pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.5E-07" displayUnit="µm">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-              <Info min="0" max="1" flag="122" seq="10" ref="0" bb="32" group="114" />
+              <Info min="0" flag="122" seq="10" ref="0" bb="32" group="55" />
             </Parameter>
-            <Parameter id="XmJX5Xv5CUeD8d0IpFUIHA" name="Radius (small pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="4.5E-08" displayUnit="µm">
+            <Parameter id="FIRAefnyTkag4Zfl2JF55Q" name="Radius (small pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="4.5E-08" displayUnit="µm">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
               <Info min="0" flag="122" seq="10" ref="0" bb="32" group="99" />
             </Parameter>
-            <Parameter id="kcS1o2Nq30OsEt_8m2dXFw" name="Vf (neutral lipid)-PT" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0048">
+            <Parameter id="N4DcrzipO0-gQS1E2YUTfw" name="Fraction vascular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.055">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
-              <Info min="0" max="1" flag="122" seq="30" ref="0" bb="32" group="86" />
+              <ValueOrigin id="40" source="Publication" description="Edginton, A.N., Schmitt, W. &amp; Willmann, S. Clin Pharmacokinet (2006) 45: 1013. https://doi.org/10.2165/00003088-200645100-00005" />
+              <Info min="0" max="1" flag="62" seq="30" ref="0" bb="32" group="64" />
             </Parameter>
-            <Parameter id="wB6BoprI4kC_lRzdMHAojQ" name="Vf (lipid)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.031">
+            <Parameter id="NBza9Lfqi06kZL5-uKxd0A" name="Vf (lipid)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.031">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
               <Info min="0" max="1" flag="122" seq="30" ref="0" bb="32" group="85" />
             </Parameter>
-            <Parameter id="jJUPX8N4nkOhmT4ATNWnJw" name="Fraction vascular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.055">
+            <Parameter id="4su8UrsEzEWZVupcSzM2fw" name="Vf (neutral lipid)-PT" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0048">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
-              <ValueOrigin id="40" source="Publication" description="Edginton, A.N., Schmitt, W. &amp; Willmann, S. Clin Pharmacokinet (2006) 45: 1013. https://doi.org/10.2165/00003088-200645100-00005" />
-              <Info min="0" max="1" flag="62" seq="30" ref="0" bb="32" group="64" />
+              <Info min="0" max="1" flag="122" seq="30" ref="0" bb="32" group="86" />
             </Parameter>
-            <Parameter id="pbnN3cFCI0-jsbsRLyPsgg" name="Vf (phospholipid)-PT" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.01405">
+            <Parameter id="8wTIo9ACjESZ8ITKVrBT3A" name="Vf (phospholipid)-PT" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.01405">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" max="1" flag="122" seq="31" ref="0" bb="32" group="86" />
             </Parameter>
-            <Parameter id="tAdzCv3eE06IBzcE8801aw" name="Vf (protein)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.12">
+            <Parameter id="GeOL3OuKqUajAi6Gs279fA" name="Vf (protein)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.12">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
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+                <Parameter id="8pp3jQWDmUuSl_mRtyJxBQ" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
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+                <Container id="cGaqvjUFnEGohY5166-5zw" name="MoleculeProperties" mode="Logical" containerType="Molecule">
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+                    <Parameter id="BEEUkq30Uk2izyOU_4_r4A" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
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+                    <Parameter id="k3s91J10REGvCCx5tYClZA" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" isDefault="1">
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                 <Tag value="Gonads" />
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+                <Parameter id="etCcQYvtj0G2OmMMuHs0nA" name="FcRn concentration in container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.FcRn_in_Container_Interstitial" isDefault="1" displayUnit="µmol/l">
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+                <Parameter id="aWtW3PBI7Eqy0W5o3r0-iw" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                  <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                </Parameter>
+                <Parameter id="A_Ar-I5zlUqspDEOonxlfw" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_int_2Pores" isDefault="1" displayUnit="l">
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+                <Parameter id="tAv2t-zQMUqcpKlVrNK6bg" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_pH_INT" isDefault="1">
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                 </Parameter>
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+                <Container id="b7upkQhEvkOqsX9zfzM87A" name="MoleculeProperties" mode="Logical" containerType="Molecule">
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+                    <Parameter id="l13vlm-CI0CV3dYM9J5J1w" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Plasma_and_Interstitial" isDefault="1" displayUnit="µmol/l">
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                     </Parameter>
-                    <Parameter id="aRyH3bJu1kuWNdNM41k15w" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                    <Parameter id="DBh39zEVXk2PSAObbxy_7Q" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
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+                    <Parameter id="IS4CCXsiIkSEMVZm0pkN2A" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_tes" isDefault="1">
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+                    <Parameter id="cjXTScVMnE-jtRnTAbm21Q" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
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               <Tags>
                 <Tag value="Gonads" />
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+                <Parameter id="U5klYiYxWUOB0BODnCXdOw" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" isDefault="1" displayUnit="l">
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+                <Parameter id="TGM-YlBlZkm_wZH0EaRNgA" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_cell_2Pores" isDefault="1" displayUnit="l">
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+                <Parameter id="X6KNBZ1JEk-quTOax5rpLw" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7">
                   <Tags>
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                 </Parameter>
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+                    <Parameter id="Ia9VtgXmjEm6ObBVuJ7bww" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
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+                    <Parameter id="8U23HVIiB0SO8c02Di95bg" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_tes" isDefault="1">
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+                    <Parameter id="eCEm76-j-UigqpYsIxREEA" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
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-            <Container id="vqDhcGRzm0axJ3Ldu4Wumw" name="Endosome" mode="Physical" containerType="Compartment">
+            <Container id="K_SjA27ZdEWrB5JOzLWlHg" name="Endosome" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="Gonads" />
               </Tags>
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-                </Parameter>
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+                <Parameter id="BYAT22hrvU2qMaouxddyAg" name="FcRn concentration in container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.FcRn_in_Container_Endosomal" isDefault="1" displayUnit="µmol/l">
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+                <Parameter id="FXw5kU_eqkmuYeVkG9UK4Q" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                  <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                </Parameter>
+                <Parameter id="JyrcuWGfNkuzKxNm2QnelA" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_end_tes" isDefault="1" displayUnit="l">
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                 </Parameter>
-                <Container id="m7l8DS3akEi1n_eLjyyY6Q" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="Y_KXFKyETUiu-u9gZyBGFg" name="MoleculeProperties" mode="Logical" containerType="Molecule">
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+                    <Parameter id="_YXVJhyhJUWzrf78vEaf8g" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Endosomal" isDefault="1" displayUnit="µmol/l">
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+                    <Parameter id="w9TLrUvH006ehSb2-eR_pg" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
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+                    <Parameter id="MpLZxbllnkS0ImzVMqrF0w" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
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                     </Parameter>
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+                    <Parameter id="JuPVqRAfQ0qWVSPbjg5qCQ" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
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@@ -2524,475 +2537,477 @@
             </Container>
           </Children>
         </Container>
-        <Container id="pqfHt-IxbESPppt27dVmsQ" name="Heart" mode="Logical" containerType="Organ">
+        <Container id="a9vc1vfAb0CM8AP-DLKkNg" name="Heart" mode="Logical" containerType="Organ">
           <Tags>
             <Tag value="TissueOrgan" />
           </Tags>
           <Children>
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+            <Parameter id="1aDGtW0P1Ee0GvfclMlLyQ" name="Fraction of endosomal uptake from plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_uptake_vas" isDefault="1">
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               <Info min="0" flag="54" seq="0" ref="0" bb="2" group="25" />
             </Parameter>
-            <Parameter id="Y9sk3XKKQ0uZwf5mcVJMLQ" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
-              <Tags>
-                <Tag value="TissueOrgan" />
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+              <Tags>
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+              </Tags>
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-            <Parameter id="x4iGF2viM0KxWlfc4LXjeA" name="Fluid recirculation flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate" isDefault="1" displayUnit="l/min">
+            <Parameter id="Vyn-qldXpkeN7ctHW4U5fA" name="Fluid recirculation flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate" isDefault="1" displayUnit="l/min">
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+            <Parameter id="nKNOIHZQhk-r7otcGA2wNg" name="Volume (endothelium)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="VascularEndoVolume.VOLUME_VascularEndo_hrt" isDefault="1" displayUnit="l">
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+            <Parameter id="Xoh_LOZ_D0KdcANM2Zdfrg" name="Fraction intracellular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_f_cell" isDefault="1">
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                 <Tag value="TissueOrgan" />
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+            <Parameter id="D54Ua92liESJx0EL6TUoeQ" name="Blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_from_Qspec" isDefault="1" displayUnit="l/min">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
-              <ValueOrigin id="48" description="TODO: Absolute from specific calculation" />
+              <ValueOrigin id="48" source="Other" description="Absolute value = specific value (i.e. value normalized to the volume of the organ) multiplied by the organ volume" />
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+            <Parameter id="5c_itYZRQ0uagnkKrafjAg" name="Fluid recirculation flow proportionality factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.96">
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+            <Parameter id="nox5JdBzcEG67iEbdj6OSQ" name="Lymph flow proportionality factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.00147">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
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+            <Parameter id="k3ra5F5p7kCH-9_DdUUJUQ" name="Organ volume mouse" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="9.5E-05" displayUnit="l">
               <Tags>
                 <Tag value="TissueOrgan" />
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-              <Info min="0" flag="122" seq="11" ref="0" bb="32" group="115" />
+              <Info min="0" flag="122" seq="11" ref="0" bb="32" group="99" />
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-            <Parameter id="XPTTMB-f0EGDuEotxG_-2Q" name="Vf (neutral lipid)-PT" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0115">
+            <Parameter id="btzmNP7yJE6jaQwkA84ZCQ" name="Fraction vascular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.14">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
-              <Info min="0" max="1" flag="122" seq="33" ref="0" bb="32" group="86" />
+              <ValueOrigin id="40" source="Publication" description="Edginton, A.N., Schmitt, W. &amp; Willmann, S. Clin Pharmacokinet (2006) 45: 1013. https://doi.org/10.2165/00003088-200645100-00005" />
+              <Info min="0" max="1" flag="62" seq="33" ref="0" bb="32" group="64" />
             </Parameter>
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+            <Parameter id="zWXAlM9QfkO-37e22axM7Q" name="Vf (lipid)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.1">
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               <Info min="0" max="1" flag="122" seq="33" ref="0" bb="32" group="85" />
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+            <Parameter id="HQAPvKNjPkW0EH1EOMi_eQ" name="Vf (neutral lipid)-PT" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0115">
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-              <Info min="0" max="1" flag="62" seq="33" ref="0" bb="32" group="64" />
+              <Info min="0" max="1" flag="122" seq="33" ref="0" bb="32" group="86" />
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-            <Parameter id="0vSgXO8juUue4KgK-XiFtA" name="Vf (phospholipid)-PT" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0166">
+            <Parameter id="iHoi1bZOIU6jzRLts8VF3w" name="Vf (phospholipid)-PT" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0166">
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               <Info min="0" max="1" flag="122" seq="34" ref="0" bb="32" group="86" />
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+            <Parameter id="uOj3TEj2m0WyEnbNNESFJQ" name="Vf (protein)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.168">
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               <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
               <Info min="0" max="1" flag="122" seq="34" ref="0" bb="32" group="85" />
             </Parameter>
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+            <Parameter id="34ZaXpOesUulvjsGyJJayA" name="Fraction interstitial" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.1">
+              <Tags>
+                <Tag value="TissueOrgan" />
+              </Tags>
+              <ValueOrigin id="19" source="Publication" description="Kawai R, Lemaire M, Steimer JL, Bruelisauer A, Niederberger W, Rowland M. Physiologically based pharmacokinetic study on a cyclosporin derivative, SDZ IMM 125. J Pharmacokinet Biopharm. 1994 Oct;22(5):327-65." />
+              <Info min="0" max="1" flag="62" seq="35" ref="0" bb="32" group="64" />
+            </Parameter>
+            <Parameter id="SUS8i4y5JUmStYtU0qqj8A" name="Albumin ratio (tissue/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.157">
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               <ValueOrigin id="22" source="Publication" description="Rodgers T, Rowland M. Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J Pharm Sci. 2006 Jun;95(6):1238-57 https://doi.org/10.1002/jps.20502" />
               <Info min="0" max="1" flag="122" seq="35" ref="0" bb="32" group="111" />
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+            <Parameter id="z6lmKQCU0020oYYcvDfvTQ" name="Albumin ratio (tissue/plasma)-PT" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
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+            <Parameter id="675IOxZIckyvw6V1ey6yww" name="Lipoprotein ratio (tissue/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.16">
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+                    <Parameter id="Bp0NzdCkCUSIqSGPXBP_6A" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
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+                    <Parameter id="FU2g1vK2H0OzZe2V0M2NEQ" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
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+                <Parameter id="qa_y_Cl2u0ueA_ISST82Ng" name="FcRn concentration in container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.FcRn_in_Container_Interstitial" isDefault="1" displayUnit="µmol/l">
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+                <Parameter id="C6NjzWHw-USidM-ijc-Nww" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                  <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                </Parameter>
+                <Parameter id="dTeAQKFH8EuaRnA3x_10tg" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_int_2Pores" isDefault="1" displayUnit="l">
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+                <Parameter id="RDh4Q7uXtU6C9SIA0ek1RQ" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_pH_INT" isDefault="1">
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+                    <Parameter id="cmU-TfMDZkSGQlS6qCGKTQ" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Plasma_and_Interstitial" isDefault="1" displayUnit="µmol/l">
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+                    <Parameter id="dQTa58gOF0WM6OxDbTXrnw" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
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+                    <Parameter id="kHfJJnWWdEOK8sqiOsIcYA" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_hrt" isDefault="1">
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+                    <Parameter id="8ldPj82DaE24FKcjdwnjmA" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
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               <Tags>
                 <Tag value="Heart" />
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+                <Parameter id="FcZBYL57YUinOLnUXSTOKg" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" isDefault="1" displayUnit="l">
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+                <Parameter id="RhDtGHdo3k6ZQzMMOy2vJw" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_cell_2Pores" isDefault="1" displayUnit="l">
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+                <Parameter id="VopPvHWNjEqyvwAM5tGC1g" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.1">
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                 </Parameter>
-                <Container id="ZWxv-moKN0uMYQdw-mG7XA" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="kJuN2JSbCk-vwmT7XGyvbw" name="MoleculeProperties" mode="Logical" containerType="Molecule">
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+                    <Parameter id="gckOASx7VUOAwCdZqJ7kig" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
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+                    <Parameter id="u8B6esiTgkqSh5XDYMYsKw" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_hrt" isDefault="1">
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+                    <Parameter id="ZdPIuPdS2U-9w8xz9dpTTA" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
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               </Children>
             </Container>
-            <Container id="I3jADwRC9Emy2AlRkskKwA" name="Endosome" mode="Physical" containerType="Compartment">
+            <Container id="P6pUnAGbakyDWoKiBVGz-w" name="Endosome" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="Heart" />
               </Tags>
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+                <Parameter id="N5EhbpknI06XW0Fg9V9ibw" name="FcRn concentration in container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.FcRn_in_Container_Endosomal" isDefault="1" displayUnit="µmol/l">
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                 </Parameter>
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+                <Parameter id="M0pDzLSFqEKfLuHG6xKrFg" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
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-                <Parameter id="1F3vwHz2nEapVASE7miY-w" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_end_hrt" isDefault="1" displayUnit="l">
+                <Parameter id="kioB01gjW0ybJG501gLaUg" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_end_hrt" isDefault="1" displayUnit="l">
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                 </Parameter>
-                <Container id="IpSz9VxQmUaHmLuGWQrygA" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="jPPSfXnrw0yMXfrnNEWMMQ" name="MoleculeProperties" mode="Logical" containerType="Molecule">
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-                    </Parameter>
-                    <Parameter id="Zyff5sGP7EWgsuYDhjhjFQ" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Endosomal" isDefault="1" displayUnit="µmol/l">
+                    <Parameter id="5UN5EiPAykaKkOUcop0CWA" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Endosomal" isDefault="1" displayUnit="µmol/l">
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                       <Info flag="52" seq="1" ref="0" bb="2" group="25" />
                     </Parameter>
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+                    <Parameter id="XoMzjMX5wEGMan2z-HU4Sg" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                    </Parameter>
+                    <Parameter id="s43XLhWyF0qQMOJUAP6PuQ" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
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                     </Parameter>
-                    <Parameter id="nsMzflUB6EqXCkafJaPJBg" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
-                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                    <Parameter id="p8IjI3rZbUSh6Rdc9jzRVw" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
+                      <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
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@@ -3000,397 +3015,395 @@
             </Container>
           </Children>
         </Container>
-        <Container id="A17w_Ug06Eeq2z9fkM_xuw" name="Kidney" mode="Logical" containerType="Organ">
+        <Container id="0E1CGPsx9EqVWl6cUDjyZQ" name="Kidney" mode="Logical" containerType="Organ">
           <Tags>
             <Tag value="TissueOrgan" />
           </Tags>
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-            <Parameter id="kycrUcbiQkqlVTiahRHXfw" name="Fraction of endosomal uptake from plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_uptake_vas" isDefault="1">
+            <Parameter id="xvWUsrowTES-4UNFhlC81Q" name="Fraction of endosomal uptake from plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_uptake_vas" isDefault="1">
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-            <Parameter id="VM5Y37qGhESfhFucpDprww" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
-              <Tags>
-                <Tag value="TissueOrgan" />
-              </Tags>
-              <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
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-            <Parameter id="h5EyFGw2okqOllg6Wzo42g" name="Rate constant for recycling from endosomal space" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_K_rec" isDefault="1" displayUnit="1/min">
+            <Parameter id="LnEF0KuS30qrdSOXPC6HAA" name="Fraction endosomal" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_endo" isDefault="1">
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-              <Info min="0" flag="54" seq="1" ref="0" bb="2" group="25" />
+              <Info min="0" max="1" flag="54" seq="1" ref="0" bb="2" group="29" />
             </Parameter>
-            <Parameter id="pww5pS1Hc0Ki9LlfRg4gvQ" name="Rate constant for endosomal uptake" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_K_uptake" isDefault="1" displayUnit="1/min">
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                 </Parameter>
-                <Parameter id="zfEZnu-AFkC8-mTkfj_6bA" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                <Parameter id="MXyxxk3wNUquukwAgMtVTQ" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
                   <Info min="0" flag="34" seq="1" ref="0" bb="32" group="144" />
                 </Parameter>
-                <Parameter id="U3bBm21c00G1OLYwhQ8MSg" name="GeometricDeviation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.6">
+                <Parameter id="Yy8X13wfSEuHRKoZ5VRgMg" name="GeometricDeviation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.6">
                   <Info min="1" flag="18" seq="1" ref="0" bb="32" group="144" />
                 </Parameter>
               </Children>
               <Info min="0" flag="106" seq="1" ref="0" bb="32" group="144" />
             </DistributedParameter>
-            <Container id="B0bd84_dikGJke9sgqiyyg" name="Stomach" mode="Physical" containerType="Compartment">
+            <Container id="dtzfXSPsqUGUqYC_ZVUnsg" name="Stomach" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="Lumen" />
                 <Tag value="LumenSegment" />
               </Tags>
               <Children>
-                <Parameter id="3HVBTvlcyEKsb3-8bpmIBQ" name="Absorption of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0" displayUnit="1/min">
+                <Parameter id="LzBkpVU__0G3J06NjFMdGQ" name="Absorption of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0" displayUnit="1/min">
                   <Info flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="AMAcHs6zUEiJa83zSfVQUg" name="FillLevelFlag" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevelFlagFlag" isDefault="1">
+                <Parameter id="tixofihWzEmuZ6yL4eDbZw" name="FillLevelFlag" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevelFlagFlag" isDefault="1">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="R_f1uMgTVUa3EG4LMTlR2Q" name="Fraction of geometric volume filled with liquid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevel" isDefault="1">
+                <Parameter id="LaXnB4JFQU2nMByMjVKGlw" name="Fraction of geometric volume filled with liquid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevel" isDefault="1">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="vTZYV4oj-UWaFMi2B-JqmA" name="Geometric surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Area" isDefault="1" displayUnit="cm²">
+                <Parameter id="sAR4ZlpA80KU__-V79lH3A" name="Geometric surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Area" isDefault="1" displayUnit="cm²">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info min="0" flag="62" seq="1" ref="0" bb="32" group="33" />
                 </Parameter>
-                <Parameter id="oNuWTJdCnUqtvmGMvBfpYA" name="GET of non-disintegrated moiety" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="60" displayUnit="min">
+                <Parameter id="YfMWwtl5hkeOQDJ18lbxLg" name="GET of non-disintegrated moiety" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="60" displayUnit="min">
                   <Info min="0" flag="122" seq="1" ref="0" bb="2" group="39" />
                 </Parameter>
-                <Parameter id="H8MUTe7dDUCaKmz0fA8uYA" name="Intestinal transit rate (absolute)" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_InverseGastricEmptyingTime" isDefault="1" displayUnit="1/min">
+                <Parameter id="m91fwmdYd0CLV3Hvl5oS4g" name="Intestinal transit rate (absolute)" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_InverseGastricEmptyingTime" isDefault="1" displayUnit="1/min">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="DRRE_ZRn4U-3hP0eduq45w" name="Liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Liquid_StartValue" isDefault="1" rHSFormula="Lumen_PKSim.LiquidRHS_sto" displayUnit="l">
+                <Parameter id="wEH0aA0YB0KsWTsfkBKtSQ" name="Liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Liquid_StartValue" isDefault="1" rHSFormula="Lumen_PKSim.LiquidRHS_sto" displayUnit="l">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="XlcI0rRXmki42g6YoPAw1A" name="Liquid transfer rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_LiquidTransferRate_sto" isDefault="1" displayUnit="l/min">
+                <Parameter id="chGYRc1gTEKvEonDFRfRNg" name="Liquid transfer rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_LiquidTransferRate_sto" isDefault="1" displayUnit="l/min">
                   <Info flag="52" seq="1" ref="0" bb="2" group="39" />
                 </Parameter>
-                <Parameter id="b6mRsWUY9Ea9q3JXEEr6CQ" name="Secretion of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Inflow_Stomach" isDefault="1" displayUnit="l/min">
+                <Parameter id="zHbvyB4dZUKz1QYGGVb7UQ" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_pH_from_pH_fasted" isDefault="1">
+                  <Tags>
+                    <Tag value="Lumen" />
+                    <Tag value="LumenSegment" />
+                  </Tags>
+                  <Info min="0" max="14" flag="52" seq="1" ref="0" bb="32" group="41" />
+                </Parameter>
+                <Parameter id="o-7nkXYlGU-xA5t7ty6KDw" name="Secretion of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Inflow_Stomach" isDefault="1" displayUnit="l/min">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="gB9qWjxo_Eic2sd22ztWQw" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_LumenSegment" isDefault="1" displayUnit="l">
+                <Parameter id="7qJ1aqzn8kywF_uxfiD-gg" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_LumenSegment" isDefault="1" displayUnit="l">
                   <Info min="0" flag="62" seq="1" ref="0" bb="2" group="56" />
                 </Parameter>
-                <Parameter id="nfZfcDC6Hkqn3m6tiNooWw" name="Volume (gut wall)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="MucosaVolume.PARAM_VolumeGutWall" isDefault="1" displayUnit="l">
+                <Parameter id="uFaoIVlUUUGJMi8qxXsJTQ" name="Volume (gut wall)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="MucosaVolume.PARAM_VolumeGutWall" isDefault="1" displayUnit="l">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info min="0" flag="62" seq="1" ref="0" bb="32" group="44" />
                 </Parameter>
-                <Parameter id="HI7YTSCLJUClZW8pgHp4DQ" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                <Parameter id="olsP6QDhA0SAwSvjWr3xGQ" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
                   <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                 </Parameter>
-                <Parameter id="oMSLKXwEMkSl7i5aae-Z5A" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_pH_from_pH_fasted" isDefault="1">
+                <Parameter id="Sj4yUa72nEWoVRKsxlpt2Q" name="Fractional steady state fill level" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.030169">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" max="14" flag="52" seq="1" ref="0" bb="32" group="41" />
+                  <Info min="0" flag="58" seq="1" ref="0" bb="32" group="43" />
                 </Parameter>
-                <Parameter id="uagkUdI9OEacatH_N6UZlw" name="Thickness of gut wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.022668" displayUnit="cm">
+                <Parameter id="27os0XBqC0-xI5Rjm5qFpg" name="pH in fed state" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="5.5">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="54" seq="1" ref="0" bb="32" group="45" />
+                  <Info min="0" max="14" flag="52" seq="1" ref="0" bb="32" group="41" />
                 </Parameter>
-                <Parameter id="tSRILRHcNk-xoqR8W7Azew" name="Fractional steady state fill level" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.030169">
+                <Parameter id="chza85vWAUue0lhE9gwCfA" name="Thickness of gut wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.022668" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="58" seq="1" ref="0" bb="32" group="43" />
+                  <Info min="0" flag="54" seq="1" ref="0" bb="32" group="45" />
                 </Parameter>
-                <Parameter id="wuMX7FLQLEey_nBqCMCPUw" name="pH in fed state" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="5.5">
+                <Parameter id="hI3dqk8e0UuEEPZLwBICkw" name="Inverse rate of inflow of liquid into stomach" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="15" displayUnit="min">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" max="14" flag="52" seq="1" ref="0" bb="32" group="41" />
+                  <Info min="1" max="10000" flag="54" seq="1" ref="0" bb="32" group="46" />
                 </Parameter>
-                <Parameter id="nPie3RSNZkqW79KVglpxpA" name="pH in fasted state" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2">
+                <Parameter id="WyuqfdhEMUi8Wgn15nnuNA" name="pH in fasted state" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
@@ -3744,19 +3768,12 @@
                   <ValueOrigin id="25" source="Publication" description="Stefan Willmann, Walter Schmitt,Jörg Keldenich, Jörg Lippert, and Jennifer B. Dressman: A Physiological Model for the Estimation of the Fraction Dose Absorbed in Humans. J. Med. Chem. 2004, 47, 4022-4031" />
                   <Info min="0" max="14" flag="122" seq="1" ref="0" bb="32" group="41" />
                 </Parameter>
-                <Parameter id="_wD-4TkA3EeQgySRsVWdzw" name="Inverse rate of inflow of liquid into stomach" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="15" displayUnit="min">
-                  <Tags>
-                    <Tag value="Lumen" />
-                    <Tag value="LumenSegment" />
-                  </Tags>
-                  <Info min="1" max="10000" flag="54" seq="1" ref="0" bb="32" group="46" />
-                </Parameter>
-                <DistributedParameter id="CGuQmogAwEaVo0-naIjXng" name="Distal radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="z_gAqjdlNUuHiXlma_FfLQ" mode="Logical" isDefault="1" displayUnit="cm">
+                <DistributedParameter id="kXduDogJ-UuzpTTdtI1JPQ" name="Distal radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="-b1K0ph5x0KxX8DiiZmjtw" mode="Logical" isDefault="1" displayUnit="cm">
                   <Children>
-                    <Parameter id="kSiROs56zk6ZeYC1gVxy9g" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5" displayUnit="cm">
+                    <Parameter id="c6OTVqNr6kiAGyYLZpY_Dw" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5" displayUnit="cm">
                       <Info min="0" flag="18" seq="1" ref="0" bb="32" group="35" />
                     </Parameter>
-                    <Parameter id="zQCijcT5P02u3bUA-R-Ppw" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5" displayUnit="cm">
+                    <Parameter id="qHpKW5MIkEONpENxVO8aEg" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5" displayUnit="cm">
                       <Info min="0" flag="50" seq="1" ref="0" bb="32" group="35" />
                     </Parameter>
                   </Children>
@@ -3766,30 +3783,33 @@
                   </Tags>
                   <Info min="0" flag="122" seq="1" ref="0" bb="32" group="35" />
                 </DistributedParameter>
-                <DistributedParameter id="cwWrVjayd0S2QAXRn_6JJA" name="Length" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="_UQGoNXuJEG0QjOcMdBRJQ" mode="Logical" isDefault="1" displayUnit="cm">
+                <DistributedParameter id="0y7lzs46EUaiof2uhazIGQ" name="Gastric emptying time" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="BBmUsKDUXkmBVnTDYvpvyA" mode="Logical" isDefault="1" displayUnit="min">
                   <Children>
-                    <Parameter id="ISFiIPpPv0-WkA9JES1rPQ" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5" displayUnit="cm">
-                      <Info min="0" flag="18" seq="1" ref="0" bb="32" group="34" />
+                    <Parameter id="8BHhEeCVa0W0fFsN0jsIFQ" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5" displayUnit="min">
+                      <Info min="0" flag="18" seq="1" ref="0" bb="32" group="46" />
                     </Parameter>
-                    <Parameter id="UAIyEuJRl0CWNX_EQcOpYw" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2" displayUnit="cm">
-                      <Info min="0" flag="50" seq="1" ref="0" bb="32" group="34" />
+                    <Parameter id="GKVhfrFSikqWWHhYEcXj8w" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="15" displayUnit="min">
+                      <Info min="1" max="10000" flag="50" seq="1" ref="0" bb="32" group="46" />
+                    </Parameter>
+                    <Parameter id="YhgIz8lXukOpW67Nib8Edg" name="GeometricDeviation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.6">
+                      <Info min="1" flag="18" seq="1" ref="0" bb="32" group="46" />
                     </Parameter>
                   </Children>
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="122" seq="1" ref="0" bb="32" group="34" />
+                  <Info min="1" max="10000" flag="122" seq="1" ref="0" bb="32" group="46" />
                 </DistributedParameter>
-                <DistributedParameter id="DYX1U7ReWESNYR3vYF5p8A" name="GET_beta (Weibull function) variability factor" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="pM9YKMqGw0-hEA9Eod94mg" mode="Logical" isDefault="1">
+                <DistributedParameter id="C_5nBIljik6KPU9fNG45Ag" name="GET_alpha (Weibull function) variability factor" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_WgKbKQzXkSWA0aCJdmKTQ" mode="Logical" isDefault="1">
                   <Children>
-                    <Parameter id="wUgRuCDfo0-fx8-EvsKY_g" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                    <Parameter id="36rW4mUh_UKnGxRq1YAqsg" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
                       <Info min="0" flag="18" seq="1" ref="0" bb="32" group="46" />
                     </Parameter>
-                    <Parameter id="80nX89YKskCdJvEF10dXfw" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                    <Parameter id="ZsXk8TR4ck-c0Kdm7Uw1KQ" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
                       <Info min="0" flag="34" seq="1" ref="0" bb="32" group="46" />
                     </Parameter>
-                    <Parameter id="0kliCJ-T-keZ2BJKuAn5Mw" name="GeometricDeviation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.32">
+                    <Parameter id="Vx9q3eiy4k2TY9SiGMTwVw" name="GeometricDeviation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.74">
                       <Info min="1" flag="18" seq="1" ref="0" bb="32" group="46" />
                     </Parameter>
                   </Children>
@@ -3799,15 +3819,15 @@
                   </Tags>
                   <Info min="0" flag="38" seq="1" ref="0" bb="32" group="46" />
                 </DistributedParameter>
-                <DistributedParameter id="py37M2egW0SoptP53jAtRA" name="Gastric emptying time" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="QBSJqaa3E0ScAhFwpuj93A" mode="Logical" isDefault="1" displayUnit="min">
+                <DistributedParameter id="7nRynBgvyEOteyB-viIyJg" name="GET_beta (Weibull function) variability factor" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="eVVbAMUi4kqE7x9fxmKY6g" mode="Logical" isDefault="1">
                   <Children>
-                    <Parameter id="jqNjwYc4f0-dVqf2lVIG9w" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5" displayUnit="min">
+                    <Parameter id="ix4AP338WUaUe0BHr9y0Eg" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
                       <Info min="0" flag="18" seq="1" ref="0" bb="32" group="46" />
                     </Parameter>
-                    <Parameter id="b_u_rvpHeU-GkEy-vZYluA" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="15" displayUnit="min">
-                      <Info min="1" max="10000" flag="50" seq="1" ref="0" bb="32" group="46" />
+                    <Parameter id="52CP4cCATECRgIBmhd4qWQ" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                      <Info min="0" flag="34" seq="1" ref="0" bb="32" group="46" />
                     </Parameter>
-                    <Parameter id="uxtnwbP6G024NlJSk-vB9g" name="GeometricDeviation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.6">
+                    <Parameter id="cQO4P7p26EqWTXMTKXoZOA" name="GeometricDeviation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.32">
                       <Info min="1" flag="18" seq="1" ref="0" bb="32" group="46" />
                     </Parameter>
                   </Children>
@@ -3815,32 +3835,29 @@
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="1" max="10000" flag="122" seq="1" ref="0" bb="32" group="46" />
+                  <Info min="0" flag="38" seq="1" ref="0" bb="32" group="46" />
                 </DistributedParameter>
-                <DistributedParameter id="GE36f-sUMUyu8OqZPcK_Ig" name="GET_alpha (Weibull function) variability factor" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="haQhuRn2GkKWf9eVe9YsLA" mode="Logical" isDefault="1">
+                <DistributedParameter id="dsEga5E2t0yB0oz_usJFHA" name="Length" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="2U3Raw0GlEOil75D_HTRXg" mode="Logical" isDefault="1" displayUnit="cm">
                   <Children>
-                    <Parameter id="hUWEgL3nI0erqk8kb-EMCA" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
-                      <Info min="0" flag="18" seq="1" ref="0" bb="32" group="46" />
-                    </Parameter>
-                    <Parameter id="CY5qLbf66kyBdzfeNvtK6w" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
-                      <Info min="0" flag="34" seq="1" ref="0" bb="32" group="46" />
+                    <Parameter id="AAv4NbIkiUmKZsb8M0aY9Q" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5" displayUnit="cm">
+                      <Info min="0" flag="18" seq="1" ref="0" bb="32" group="34" />
                     </Parameter>
-                    <Parameter id="IfI1-zolpEKoh4rhRs7LoQ" name="GeometricDeviation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.74">
-                      <Info min="1" flag="18" seq="1" ref="0" bb="32" group="46" />
+                    <Parameter id="5fPmIWT67EGHKolFKSNP0A" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2" displayUnit="cm">
+                      <Info min="0" flag="50" seq="1" ref="0" bb="32" group="34" />
                     </Parameter>
                   </Children>
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="38" seq="1" ref="0" bb="32" group="46" />
+                  <Info min="0" flag="122" seq="1" ref="0" bb="32" group="34" />
                 </DistributedParameter>
-                <DistributedParameter id="gXs9bg2vgECXrfR235OFXg" name="Proximal radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="2kkplPZs6kGb3nFYDdukYQ" mode="Logical" isDefault="1" displayUnit="cm">
+                <DistributedParameter id="fXPhZEHuqkuG5R-dlADoyA" name="Proximal radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="itym0iSEF0mnCk-OLVVhtQ" mode="Logical" isDefault="1" displayUnit="cm">
                   <Children>
-                    <Parameter id="g9V7cVru9EyMfE-GiZyTew" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5" displayUnit="cm">
+                    <Parameter id="LeOS2oigeEuk7g0OvVdfkg" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5" displayUnit="cm">
                       <Info min="0" flag="18" seq="1" ref="0" bb="32" group="35" />
                     </Parameter>
-                    <Parameter id="L4OUsynjFkOhH8YwqSKCTg" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5" displayUnit="cm">
+                    <Parameter id="P8RliFZ3VEaO3eekstGnQQ" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5" displayUnit="cm">
                       <Info min="0" flag="50" seq="1" ref="0" bb="32" group="35" />
                     </Parameter>
                   </Children>
@@ -3850,231 +3867,234 @@
                   </Tags>
                   <Info min="0" flag="122" seq="1" ref="0" bb="32" group="35" />
                 </DistributedParameter>
-                <Container id="4Ais3r_6wEWW7AIRwaiUvg" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="RsUOftsec0Ov5QlGynIDPw" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                   <Children>
-                    <Parameter id="il_T98IQwEGtehCYG581-g" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" isDefault="1">
-                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
-                    </Parameter>
-                    <Parameter id="VEpjaX6UcUOJ-RPBBip34w" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal_GI" isDefault="1">
+                    <Parameter id="6L0dSUkNtk-UD2IZ-Q-q-w" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal_GI" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                     </Parameter>
-                    <Parameter id="qXWWiWT8b0a32cpbd1r71A" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" isDefault="1">
+                    <Parameter id="Yc2FMTk8o0G43BjeYTHxRQ" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                    </Parameter>
+                    <Parameter id="KTkRZcHYwUSvpCQL4Kelow" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                    </Parameter>
+                    <Parameter id="SEeKufU0OEKUc8K__cf70w" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="faxnu8gjGk6sjfp_vLzYPA" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" isDefault="1">
+                    <Parameter id="3_fTHxoBQEWXXV1j4nh3zg" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="ZwiDgD409ECF2aFHQmPf5g" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" isDefault="1">
+                    <Parameter id="4cihNlJ0LUe-1SkL4UNBFg" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="cZj0nATObk-2ii4G-Q-2kg" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" isDefault="1">
+                    <Parameter id="MKQg5F-Sg0ea3pkCcCgCbg" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="8GL3Cfke60qoDVC_Bn1VQg" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" isDefault="1">
+                    <Parameter id="G8aXACjglkKP1MSWHflt6w" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="ssI36-UzXEKaEe_dRZaXmg" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" isDefault="1">
+                    <Parameter id="DpOzuFx--kKVFiuumFQDTg" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="snUdlX0c60erk4wGnUDVSg" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" isDefault="1">
+                    <Parameter id="s2swJXh52UCPzWb-HyHX-A" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="PHrAanQCn0SMnqybH_ut7w" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" isDefault="1">
+                    <Parameter id="MJcF0Shb3EGAyVQQRYESsw" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="8bhcVeJtk0iHQuq7qR_p9g" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" isDefault="1">
+                    <Parameter id="6ns_ER3ba0KZC6KFKAdnHw" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="ygxWHAaGgkenNKo6vV3OUw" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" isDefault="1">
+                    <Parameter id="fHkLX9y-8Ea3P_IEHEc7Tg" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="R30knve3_kax5pMs2RNjXw" name="Solubility" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_IntestinalSolubility" isDefault="1" displayUnit="mg/l">
+                    <Parameter id="opOsE__g3UeQLonmiO6BSg" name="Solubility" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_IntestinalSolubility" isDefault="1" displayUnit="mg/l">
                       <Info min="0" flag="122" seq="1" ref="0" bb="2" group="42" />
                     </Parameter>
-                    <Parameter id="JlwFm8JPc0GYCH1w-5WJaQ" name="Solubility table" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.TableFormulaWithXArgument_SolubilityTable" isDefault="1" displayUnit="mg/l">
+                    <Parameter id="FotZb-i6V0mh7war56hHQg" name="Solubility table" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.TableFormulaWithXArgument_SolubilityTable" isDefault="1" displayUnit="mg/l">
                       <Info min="0" flag="50" seq="1" ref="0" bb="2" group="42" />
                     </Parameter>
-                    <Parameter id="1Bk3HsK1XkKtzlVmhgcv-g" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
-                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
-                    </Parameter>
-                    <Parameter id="pStCiU5jTkWfv7r2NP6YTg" name="Solubility_pKa_pH_Factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" isDefault="1">
+                    <Parameter id="1T4j76zaY0aZM19YypR_0A" name="Solubility_pKa_pH_Factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="jWHLmmE0Yk-quPwXXyTXXA" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                    <Parameter id="Nqfv9Fm390inCQb4Po3YCA" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
                       <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                     </Parameter>
+                    <Parameter id="Ol7Lh-z3P0CGuWnDQAkRFw" name="Effective concentration in lumen" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_EffectiveLumenConcentration" isDefault="1" displayUnit="µmol/l">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="42" />
+                    </Parameter>
                   </Children>
                 </Container>
               </Children>
             </Container>
-            <Container id="Soy8bWRBA0aKD_xjTO8QdQ" name="Duodenum" mode="Physical" containerType="Compartment">
+            <Container id="Q2OaqR8Xk0-oRedeXkkAcA" name="Duodenum" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="Lumen" />
                 <Tag value="LumenSegment" />
               </Tags>
               <Children>
-                <Parameter id="OXPYeXfAJU-GhcX462bfVw" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_LumenSegment" isDefault="1" displayUnit="l">
-                  <Info min="0" flag="62" seq="1" ref="0" bb="2" group="56" />
+                <Parameter id="tU1fdXSARkO0gBRYFOe8SQ" name="Absorption of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Outflow_Duodenum" isDefault="1" displayUnit="1/min">
+                  <Info flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="L5etXuiynUCHrcZ0nXMK9w" name="Intestinal transit rate (absolute)" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_InverseSITT_Factor_Duodenum" isDefault="1" displayUnit="1/min">
-                  <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                <Parameter id="Y8E1d7yLlE-2SGNnSRQcZw" name="Distal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R2" isDefault="1" displayUnit="cm">
+                  <Tags>
+                    <Tag value="Lumen" />
+                    <Tag value="LumenSegment" />
+                  </Tags>
+                  <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="rrRGCBxyxkCcvXDX6rhLBw" name="Length" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Length" isDefault="1" displayUnit="cm">
+                <Parameter id="Qn6-JurZJUKOBOnTG-bYng" name="Effective surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_EffectiveSurfaceArea" isDefault="1" displayUnit="cm²">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="106" seq="1" ref="0" bb="32" group="34" />
+                  <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
+                  <Info min="0" flag="52" seq="1" ref="0" bb="32" group="33" />
                 </Parameter>
-                <Parameter id="MlvQrtHdG0e5DB_KMwXSBw" name="Liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Liquid_StartValue" isDefault="1" rHSFormula="Lumen_PKSim.LiquidRHS_duo" displayUnit="l">
+                <Parameter id="NLPLWc9oPUqF5Q_PBZVNdQ" name="FillLevelFlag" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevelFlagFlag" isDefault="1">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="iaGb5UDiqUGGSpiOZQTt7g" name="Liquid transfer rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_LiquidTransferRate_duo" isDefault="1" displayUnit="l/min">
-                  <Info flag="52" seq="1" ref="0" bb="2" group="39" />
+                <Parameter id="0tttpPqQSEC-FkMX_55ADA" name="Fraction of geometric volume filled with liquid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevel" isDefault="1">
+                  <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="GOrmm4dsyUWK9cA2JWPbww" name="Proximal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R1" isDefault="1" displayUnit="cm">
+                <Parameter id="bSvRxT0G6keaYAGItBnEBw" name="Geometric surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Area" isDefault="1" displayUnit="cm²">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
+                  <Info min="0" flag="62" seq="1" ref="0" bb="32" group="33" />
                 </Parameter>
-                <Parameter id="R3aRi0InKUCQ1mwH8XH-Fg" name="Secretion of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Inflow_Duodenum" isDefault="1" displayUnit="l/min">
+                <Parameter id="6-vgJ1AET02rZmhrAvvV3w" name="Intestinal transit rate (absolute)" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_InverseSITT_Factor_Duodenum" isDefault="1" displayUnit="1/min">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="WavnZyMugEOVkW5qFaqI4g" name="Thickness of gut wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Thickness" isDefault="1" displayUnit="cm">
+                <Parameter id="7BZVgakRRkalCYV4k537rA" name="Length" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Length" isDefault="1" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="38" seq="1" ref="0" bb="32" group="45" />
+                  <Info min="0" flag="106" seq="1" ref="0" bb="32" group="34" />
                 </Parameter>
-                <Parameter id="zzE65EaCaker9lKErYnRQQ" name="FillLevelFlag" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevelFlagFlag" isDefault="1">
+                <Parameter id="fSmi9UYbX0yE7X5WBPuZLA" name="Liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Liquid_StartValue" isDefault="1" rHSFormula="Lumen_PKSim.LiquidRHS_duo" displayUnit="l">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="UpmxDZDe_UCnswOchm2O5g" name="Volume (gut wall)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="MucosaVolume_Human.PARAM_VolumeGutWall_Duodenum" isDefault="1" displayUnit="l">
+                <Parameter id="ZDDWG1MbgE2wUJRfX4x27g" name="Liquid transfer rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_LiquidTransferRate_duo" isDefault="1" displayUnit="l/min">
+                  <Info flag="52" seq="1" ref="0" bb="2" group="39" />
+                </Parameter>
+                <Parameter id="-JJY7sp8jEuhiDwPf1qC8g" name="Proximal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R1" isDefault="1" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="62" seq="1" ref="0" bb="32" group="44" />
+                  <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="Nf9OKTXn9EipzOHkr0KwzA" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
-                  <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                <Parameter id="lBKVOUOWp06AIdWT7xJB-Q" name="Secretion of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Inflow_Duodenum" isDefault="1" displayUnit="l/min">
+                  <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="w9TpZZkTO0uPSQ1DoHZTwA" name="Geometric surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Area" isDefault="1" displayUnit="cm²">
+                <Parameter id="osV_ZaVOsUe7ZEnIVPBtlQ" name="Thickness of gut wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Thickness" isDefault="1" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="62" seq="1" ref="0" bb="32" group="33" />
-                </Parameter>
-                <Parameter id="gQLqik9XSEibR1XX25mQ_w" name="Fraction of geometric volume filled with liquid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevel" isDefault="1">
-                  <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                  <Info min="0" flag="38" seq="1" ref="0" bb="32" group="45" />
                 </Parameter>
-                <Parameter id="Pn81bGykekGGn48orgB6ng" name="Absorption of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Outflow_Duodenum" isDefault="1" displayUnit="1/min">
-                  <Info flag="54" seq="1" ref="0" bb="2" group="63" />
+                <Parameter id="dBfh8Uy5d0iwLDA3Sufhlg" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_LumenSegment" isDefault="1" displayUnit="l">
+                  <Info min="0" flag="62" seq="1" ref="0" bb="2" group="56" />
                 </Parameter>
-                <Parameter id="KTSGfdx-XEq09mpXeYdFLA" name="Distal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R2" isDefault="1" displayUnit="cm">
+                <Parameter id="jqpzTck1p0iClXa4UV_lOQ" name="Volume (gut wall)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="MucosaVolume_Human.PARAM_VolumeGutWall_Duodenum" isDefault="1" displayUnit="l">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
+                  <Info min="0" flag="62" seq="1" ref="0" bb="32" group="44" />
+                </Parameter>
+                <Parameter id="T2_HqYM3aE6cg0txU_CV7Q" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                  <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                 </Parameter>
-                <Parameter id="RZ-8rhHRWk6OmkTNk1TN0A" name="Effective surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_EffectiveSurfaceArea" isDefault="1" displayUnit="cm²">
+                <Parameter id="KaVwpEsb9kK724YJ8PZQBQ" name="Fractional steady state fill level" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.06">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
-                  <Info min="0" flag="52" seq="1" ref="0" bb="32" group="33" />
+                  <Info min="0" flag="58" seq="1" ref="0" bb="32" group="43" />
                 </Parameter>
-                <Parameter id="4L5fDJXQ4EK2bLmtyH9TyQ" name="Microvilli factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="25">
+                <Parameter id="lS0cLjzwyUqKlwqxH1YRcQ" name="Intestinal transit rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="116" displayUnit="1/min">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="38" seq="1" ref="0" bb="32" group="33" />
+                  <Info min="0" flag="54" seq="1" ref="0" bb="32" group="46" />
                 </Parameter>
-                <Parameter id="nWSH74lXEEGm-QwUl4yNeg" name="L_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0289872252" displayUnit="cm">
+                <Parameter id="6tm65ldJ7E6gG4MSs8nK1A" name="L_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0289872252" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info flag="54" seq="1" ref="0" bb="32" group="34" />
                 </Parameter>
-                <Parameter id="KaYL8pOZYk-mRW2wG-gn5w" name="Intestinal transit rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="116" displayUnit="1/min">
+                <Parameter id="4U6FZROD00m5NiyVmZ3M5w" name="L_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.129622362">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="54" seq="1" ref="0" bb="32" group="46" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="34" />
                 </Parameter>
-                <Parameter id="6DPrTf67l0iXn07xnCwTRA" name="Fractional steady state fill level" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.06">
+                <Parameter id="7i5mBYavzEe-ir2THvXa_g" name="Microvilli factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="25">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="58" seq="1" ref="0" bb="32" group="43" />
+                  <Info min="0" flag="38" seq="1" ref="0" bb="32" group="33" />
                 </Parameter>
-                <Parameter id="ACVMzPMQSECd9cUR9Vui3Q" name="r1_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.002264627" displayUnit="cm">
+                <Parameter id="ZGCXpysr2EqsUmmWOIfhLQ" name="r1_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.002264627" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="Is57GBNiuUy9aunn5AzoOg" name="L_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.129622362">
+                <Parameter id="aqR3G7WK7U-5SuU3_nKVAA" name="r1_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.010126747">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="34" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="AVljuFfPtUqN8LSTfGHaEg" name="Thickness_p3" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.30705627" displayUnit="1/cm">
+                <Parameter id="T9HLPLJ8F0WtYUFn0QJ9WQ" name="r2_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0020705161" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="E23GWPtgFUihXHQKJq3NRA" name="Thickness_p2" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0441002752" displayUnit="cm">
+                <Parameter id="hCBmoeJt-kum9Rgfd9SLEQ" name="r2_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.00925874">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="yd_IbES2gUi0mqAm5iEmog" name="Thickness_p1" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0186500479" displayUnit="cm">
+                <Parameter id="umdejyYj1EyA7bwVrSWHiw" name="Thickness_p1" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0186500479" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info flag="54" seq="1" ref="0" bb="32" group="45" />
                 </Parameter>
-                <Parameter id="7F7VBxlyjU-4DkQ7pcPSeg" name="r2_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.00925874">
+                <Parameter id="kJBUaqMiq02A8wZPzeFUpQ" name="Thickness_p2" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0441002752" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
-                </Parameter>
-                <Parameter id="xiHSYuBl3EyjxQLyYt11Cw" name="r2_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0020705161" displayUnit="cm">
-                  <Tags>
-                    <Tag value="Lumen" />
-                    <Tag value="LumenSegment" />
-                  </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
                 </Parameter>
-                <Parameter id="ZaGkFG5bLUqivJFsQaw4-A" name="r1_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.010126747">
+                <Parameter id="F0uJyQwUvU2IaMAsVxTwWQ" name="Thickness_p3" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.30705627" displayUnit="1/cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
                 </Parameter>
-                <Parameter id="LuYD9WRZ7km4pl3E1nWM0g" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="6">
+                <Parameter id="3VyoQYQc_EWbgHK6-Vg7EQ" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="6">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
@@ -4082,12 +4102,12 @@
                   <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
                   <Info min="0" max="14" flag="122" seq="1" ref="0" bb="32" group="41" />
                 </Parameter>
-                <DistributedParameter id="vGfdqxpHQE-h-6jU7VR4PQ" name="Effective surface area enhancement factor" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="gY3JaRFlu0ag7ed3Slm43g" mode="Logical" isDefault="1">
+                <DistributedParameter id="ekEuatUh2k24KzXyTr_JVQ" name="Effective surface area enhancement factor" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="dxKm928XHEOymzP2Je7jLA" mode="Logical" isDefault="1">
                   <Children>
-                    <Parameter id="5JTFkj2QX0q1QYt65iO9nw" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                    <Parameter id="Et2zdU8InkuFP_YzwWQenA" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
                       <Info min="0" flag="18" seq="1" ref="0" bb="32" group="32" />
                     </Parameter>
-                    <Parameter id="jElH1B-RyU6aKGzGxVbSAA" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="292.6883">
+                    <Parameter id="iH7ELC-UOkGAaHLrRoG6sQ" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="292.6883">
                       <Info min="0" flag="50" seq="1" ref="0" bb="32" group="32" />
                     </Parameter>
                   </Children>
@@ -4097,234 +4117,237 @@
                   </Tags>
                   <Info min="0" flag="122" seq="1" ref="0" bb="32" group="32" />
                 </DistributedParameter>
-                <Container id="sC5ccgwvnkO50kw52soexA" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="dE-2scFtdUOuDGZqYAUJrw" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                   <Children>
-                    <Parameter id="BoEAaW7BeEaB_8BWd_KnAQ" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" isDefault="1">
-                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
-                    </Parameter>
-                    <Parameter id="JjyBiAho40qTHuAGXf4O2g" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal_GI" isDefault="1">
+                    <Parameter id="Hy7joRCB1kWHuu6e_WQLVw" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal_GI" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                     </Parameter>
-                    <Parameter id="G-Bf-4zxaEqQjfEiJ626oA" name="Oral mass absorbed segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" rHSFormula="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_duo" value="0" displayUnit="µmol">
+                    <Parameter id="WPk564jYqEq43lcaWeUC9g" name="Oral mass absorbed segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" rHSFormula="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_duo" value="0" displayUnit="µmol">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                     </Parameter>
-                    <Parameter id="42tWz3F-vk2ITO0797fGdA" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" isDefault="1">
+                    <Parameter id="4FgVj1gSi0qrK3FIF-r-UQ" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                    </Parameter>
+                    <Parameter id="w_i8oQNAskiPlD4G7QZonQ" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                    </Parameter>
+                    <Parameter id="y-jBs80e60C3-hNxWWP85A" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="2L9WeYB_skOYAZwHYLqp4Q" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" isDefault="1">
+                    <Parameter id="cOp0aJHUFEuSp3Xs-7jMkg" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="Fbit4uGhQ0uoa_JwZGgrJg" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" isDefault="1">
+                    <Parameter id="fUkqWQdKOUS1bklGA6iN-A" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="CZ5V8HVfmU6piZiPpjq0rg" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" isDefault="1">
+                    <Parameter id="7TWW4mbE_k6b_AxUp_i-2A" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="Vb_pn71cTUWso_ilZP_ECQ" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" isDefault="1">
+                    <Parameter id="OXm0xmMw1UGwQzljFfYmVQ" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="0UEwWM0fdkCvR5FqS1tGXg" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" isDefault="1">
+                    <Parameter id="dXvB0VmkSE-CunM_YsdU0Q" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="sM2YvABU2EycSrQzWbR0Eg" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" isDefault="1">
+                    <Parameter id="ITtoES7GiECaoCC0KPzRcA" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="C1jf2UilCU6KXXAmZtG6yw" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" isDefault="1">
+                    <Parameter id="vt0R1x691kGgO494UoN9Dg" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="3BlSYuN80E2C2wsDGh_cjg" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" isDefault="1">
+                    <Parameter id="aK2w_TTIC0GEYZ1p2Sjw-g" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="WZ399vLX-ECxj-kyERjUBA" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" isDefault="1">
+                    <Parameter id="oYJyHCd6RkS2wPn6M4PqaQ" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="abt_NelbIUqqRlXEAFJKoQ" name="Solubility" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_IntestinalSolubility" isDefault="1" displayUnit="mg/l">
+                    <Parameter id="IbAvLv2XJEW5CRm8fkxPDQ" name="Solubility" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_IntestinalSolubility" isDefault="1" displayUnit="mg/l">
                       <Info min="0" flag="122" seq="1" ref="0" bb="2" group="42" />
                     </Parameter>
-                    <Parameter id="_e9WrK46OEWJDXuDBptmqg" name="Solubility table" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.TableFormulaWithXArgument_SolubilityTable" isDefault="1" displayUnit="mg/l">
+                    <Parameter id="IurH1cdVsE6tsODDbCOLhQ" name="Solubility table" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.TableFormulaWithXArgument_SolubilityTable" isDefault="1" displayUnit="mg/l">
                       <Info min="0" flag="50" seq="1" ref="0" bb="2" group="42" />
                     </Parameter>
-                    <Parameter id="C7q0K6d-pUG5rKmPAhbQ1g" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
-                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
-                    </Parameter>
-                    <Parameter id="CNoLo2anoEaSnSzQgAn0ug" name="Solubility_pKa_pH_Factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" isDefault="1">
+                    <Parameter id="OC0z1V2nPESRhiULdAIVdQ" name="Solubility_pKa_pH_Factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="HssvYAWwLES4QcPjD2INsA" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                    <Parameter id="OSN84fEq-0m2UDHGKW31Sw" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
                       <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                     </Parameter>
+                    <Parameter id="EYTwUL3kxk6AzY1HMU6mXw" name="Effective concentration in lumen" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_EffectiveLumenConcentration" isDefault="1" displayUnit="µmol/l">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="42" />
+                    </Parameter>
                   </Children>
                 </Container>
               </Children>
             </Container>
-            <Container id="z54PqeD3mkafETZ2sl_c1A" name="UpperJejunum" mode="Physical" containerType="Compartment">
+            <Container id="LPz6GLczUEWKm6sHP_khAQ" name="UpperJejunum" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="Lumen" />
                 <Tag value="LumenSegment" />
               </Tags>
               <Children>
-                <Parameter id="MIIZA7lhz0GxZbSow6smMA" name="Intestinal transit rate (absolute)" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_InverseSITT_Factor_UpperJejunum" isDefault="1" displayUnit="1/min">
-                  <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                <Parameter id="kCSJwMQVQUqRhMD5cv2SJg" name="Absorption of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Outflow_UpperJejunum" isDefault="1" displayUnit="1/min">
+                  <Info flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="BMq4OVjg3UqpPVUxGJEhaw" name="Volume (gut wall)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="MucosaVolume_Human.PARAM_VolumeGutWall_UpperJejunum" isDefault="1" displayUnit="l">
+                <Parameter id="Bl_PqQS5O0y9u3KlQfBjCg" name="Distal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R2" isDefault="1" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="62" seq="1" ref="0" bb="32" group="44" />
+                  <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="_M2ifergIUGtr1dJ97v8SQ" name="Liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Liquid_StartValue" isDefault="1" rHSFormula="Lumen_PKSim.LiquidRHS_uje" displayUnit="l">
-                  <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
-                </Parameter>
-                <Parameter id="q9sIjmsj0k2vSapBQeIsFA" name="Liquid transfer rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_LiquidTransferRate_uje" isDefault="1" displayUnit="l/min">
-                  <Info flag="52" seq="1" ref="0" bb="2" group="39" />
-                </Parameter>
-                <Parameter id="IBJK6stGHUWhbaLjU8CaEQ" name="Proximal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R1" isDefault="1" displayUnit="cm">
+                <Parameter id="bzHXVnO-YUKnXlII7fF_Rg" name="Effective surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_EffectiveSurfaceArea" isDefault="1" displayUnit="cm²">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
+                  <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
+                  <Info min="0" flag="52" seq="1" ref="0" bb="32" group="33" />
+                </Parameter>
+                <Parameter id="9YgpaDNweEa60EHjca8njg" name="FillLevelFlag" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevelFlagFlag" isDefault="1">
+                  <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="y0LR2QxbX02x0aYAe9kcNw" name="Secretion of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Inflow_UpperJejunum" isDefault="1" displayUnit="l/min">
+                <Parameter id="9lq4dlMOx0KX9eEkV6NwZw" name="Fraction of geometric volume filled with liquid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevel" isDefault="1">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="_DbJ9qGSZU6EgxhesPT6Cg" name="Thickness of gut wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Thickness" isDefault="1" displayUnit="cm">
+                <Parameter id="HMktT7vs00-Q-nNKTioF_w" name="Geometric surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Area" isDefault="1" displayUnit="cm²">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="38" seq="1" ref="0" bb="32" group="45" />
-                </Parameter>
-                <Parameter id="CEln4t7IokqWwUQUbxRlmw" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
-                  <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                  <Info min="0" flag="62" seq="1" ref="0" bb="32" group="33" />
                 </Parameter>
-                <Parameter id="M7Yv99-3_Ei5KchTjQaW4g" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_LumenSegment" isDefault="1" displayUnit="l">
-                  <Info min="0" flag="62" seq="1" ref="0" bb="2" group="56" />
+                <Parameter id="DjGNDmxL9EixDDN5B5-rXQ" name="Intestinal transit rate (absolute)" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_InverseSITT_Factor_UpperJejunum" isDefault="1" displayUnit="1/min">
+                  <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="hwwNYyITDEWEsoaVj2jsiw" name="Geometric surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Area" isDefault="1" displayUnit="cm²">
+                <Parameter id="5iN3se-LjUaf8_WF6Tyqgw" name="Length" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Length" isDefault="1" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="62" seq="1" ref="0" bb="32" group="33" />
+                  <Info min="0" flag="106" seq="1" ref="0" bb="32" group="34" />
                 </Parameter>
-                <Parameter id="egMADVYKj0e5OzY3rbS0rQ" name="Length" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Length" isDefault="1" displayUnit="cm">
+                <Parameter id="eFxzP_IzKE2ihKto5yFw-g" name="Liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Liquid_StartValue" isDefault="1" rHSFormula="Lumen_PKSim.LiquidRHS_uje" displayUnit="l">
+                  <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                </Parameter>
+                <Parameter id="VeJ5SXdD-Um_3ZZqk3tQuA" name="Liquid transfer rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_LiquidTransferRate_uje" isDefault="1" displayUnit="l/min">
+                  <Info flag="52" seq="1" ref="0" bb="2" group="39" />
+                </Parameter>
+                <Parameter id="zGxf255XOUah0-74yOgUSw" name="Proximal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R1" isDefault="1" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="106" seq="1" ref="0" bb="32" group="34" />
+                  <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="GXq68BwqZEa368Oart1B-g" name="Absorption of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Outflow_UpperJejunum" isDefault="1" displayUnit="1/min">
-                  <Info flag="54" seq="1" ref="0" bb="2" group="63" />
+                <Parameter id="7yAqlZLoKkm4qtzAKBxXyw" name="Secretion of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Inflow_UpperJejunum" isDefault="1" displayUnit="l/min">
+                  <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="oYmSPSxJQkiX6AeAmiWowg" name="Distal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R2" isDefault="1" displayUnit="cm">
+                <Parameter id="ruQWWxhhBEWcLAkt7fwTRA" name="Thickness of gut wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Thickness" isDefault="1" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
+                  <Info min="0" flag="38" seq="1" ref="0" bb="32" group="45" />
+                </Parameter>
+                <Parameter id="NIvl3G2EW06RuESgEjIBtg" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_LumenSegment" isDefault="1" displayUnit="l">
+                  <Info min="0" flag="62" seq="1" ref="0" bb="2" group="56" />
                 </Parameter>
-                <Parameter id="cCZ4p-GUVEOoGDj-1nzoRw" name="Effective surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_EffectiveSurfaceArea" isDefault="1" displayUnit="cm²">
+                <Parameter id="UYYD2_WZjECHEFYktXoBgw" name="Volume (gut wall)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="MucosaVolume_Human.PARAM_VolumeGutWall_UpperJejunum" isDefault="1" displayUnit="l">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
-                  <Info min="0" flag="52" seq="1" ref="0" bb="32" group="33" />
-                </Parameter>
-                <Parameter id="jVScLEUFTkOc3Xh1Kx67-w" name="FillLevelFlag" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevelFlagFlag" isDefault="1">
-                  <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                  <Info min="0" flag="62" seq="1" ref="0" bb="32" group="44" />
                 </Parameter>
-                <Parameter id="01b7Yqp8x0-HVHlTk4K6dQ" name="Fraction of geometric volume filled with liquid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevel" isDefault="1">
-                  <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                <Parameter id="BolqJf0LYE-yF5VxK5DLbQ" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                  <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                 </Parameter>
-                <Parameter id="-DjSoVjKTU2mm-PoM5eS7A" name="r1_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.00925874">
+                <Parameter id="YwK8fWVtBkaUmGxl8YAHCA" name="Fractional steady state fill level" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.064841">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                  <Info min="0" flag="58" seq="1" ref="0" bb="32" group="43" />
                 </Parameter>
-                <Parameter id="yGAxo3F0S0Sqh2pHz7LaIA" name="r1_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0020705161" displayUnit="cm">
+                <Parameter id="PcWnrwZwoUOG0X9fg6GFWw" name="Intestinal transit rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="5.0162" displayUnit="1/min">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                  <Info min="0" flag="54" seq="1" ref="0" bb="32" group="46" />
                 </Parameter>
-                <Parameter id="REDmf8UdzUyq3ICLaOh5hw" name="Microvilli factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="25">
+                <Parameter id="JgMw7_xS9U2h3iLkaaeFaA" name="L_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0670329582" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="38" seq="1" ref="0" bb="32" group="33" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="34" />
                 </Parameter>
-                <Parameter id="0x8crOFtW0-7G6HFFNdVHQ" name="L_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.299751712">
+                <Parameter id="KgUQEQCJoEeXQTUxaStvAg" name="L_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.299751712">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info flag="54" seq="1" ref="0" bb="32" group="34" />
                 </Parameter>
-                <Parameter id="kLJdxLXQ2UeY94l79scEAA" name="L_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0670329582" displayUnit="cm">
+                <Parameter id="5FtPV8gLD0ChNOOvtOG9kQ" name="Microvilli factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="25">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="34" />
+                  <Info min="0" flag="38" seq="1" ref="0" bb="32" group="33" />
                 </Parameter>
-                <Parameter id="ew16e_2nqUuV6avnA58k6w" name="r2_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.008680069">
+                <Parameter id="3DTvtaI7O0OjwVXCZCePCw" name="r1_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0020705161" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="m7esEWQS2U2Tat0jXqbxVw" name="Fractional steady state fill level" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.064841">
+                <Parameter id="-SRY8gBLz0mAX8n8LkvR1w" name="r1_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.00925874">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="58" seq="1" ref="0" bb="32" group="43" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="QaEP2yZ4pEeq_pIhfO7g5A" name="Thickness_p1" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.024936327" displayUnit="cm">
+                <Parameter id="FzJ_8yEotESSkK3HBkvohQ" name="r2_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0019411088" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="nvBucvIT3Uuv539VOJg3vw" name="Intestinal transit rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="5.0162" displayUnit="1/min">
+                <Parameter id="5GQD8UOPTkCOjwnJQQjmLA" name="r2_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.008680069">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="54" seq="1" ref="0" bb="32" group="46" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="smVeBImz_U-aGhXadYl6WQ" name="r2_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0019411088" displayUnit="cm">
+                <Parameter id="scXHpkEsKE2Ss0Ml_aN_jA" name="Thickness_p1" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.024936327" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
                 </Parameter>
-                <Parameter id="VE405an6tECHXZmyLM8wRA" name="Thickness_p3" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.30703115" displayUnit="1/cm">
+                <Parameter id="n4SI0Hga6EyfamO9e4gHMQ" name="Thickness_p2" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0589752766" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info flag="54" seq="1" ref="0" bb="32" group="45" />
                 </Parameter>
-                <Parameter id="6tu-A2tjXkyu0hGhO5bJ7g" name="Thickness_p2" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0589752766" displayUnit="cm">
+                <Parameter id="FhhITF-1pEWY-sX9zYexHg" name="Thickness_p3" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.30703115" displayUnit="1/cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info flag="54" seq="1" ref="0" bb="32" group="45" />
                 </Parameter>
-                <Parameter id="asD6YveW4ECDzXIqej8WGg" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="6.25">
+                <Parameter id="rojaXjwVcUyl3RCXP2-fBw" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="6.25">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
@@ -4332,12 +4355,12 @@
                   <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
                   <Info min="0" max="14" flag="122" seq="1" ref="0" bb="32" group="41" />
                 </Parameter>
-                <DistributedParameter id="lf1Rp-lRlkawDUwpraGRzQ" name="Effective surface area enhancement factor" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="JfKBMBXxB0KGHUSs2Oxiog" mode="Logical" isDefault="1">
+                <DistributedParameter id="52JkjidC_kCOBGDnqbrvhQ" name="Effective surface area enhancement factor" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="dCfBhmckrEOaqd73ECRP8A" mode="Logical" isDefault="1">
                   <Children>
-                    <Parameter id="9UAxro6UckaMUOz_Cws1FQ" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                    <Parameter id="qUuQpWKCI0SJn-UmMTmW5w" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
                       <Info min="0" flag="18" seq="1" ref="0" bb="32" group="32" />
                     </Parameter>
-                    <Parameter id="pbkWdHA4DUG5VBoKCqWO8g" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="447.9877">
+                    <Parameter id="Fez6VYvnaEmNBsSATKqdsQ" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="447.9877">
                       <Info min="0" flag="50" seq="1" ref="0" bb="32" group="32" />
                     </Parameter>
                   </Children>
@@ -4347,234 +4370,237 @@
                   </Tags>
                   <Info min="0" flag="122" seq="1" ref="0" bb="32" group="32" />
                 </DistributedParameter>
-                <Container id="XaKdia9ZLUmN3lux6LBcmw" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="-u_-PSXQ1EuZeUH_znp5wQ" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                   <Children>
-                    <Parameter id="d9RayWbzfke_coKEm-Zk3A" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" isDefault="1">
-                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                    <Parameter id="QBNP79SSd0S_OHz73cBv2A" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal_GI" isDefault="1">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                     </Parameter>
-                    <Parameter id="Zuf3K9mTIUihGDJvLPhQtw" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" isDefault="1">
-                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                    <Parameter id="PxySGUte9UmXvziEqlLjMA" name="Oral mass absorbed segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" rHSFormula="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_uje" value="0" displayUnit="µmol">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                     </Parameter>
-                    <Parameter id="jbOmUy9OJEKGiAAbigQ0og" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" isDefault="1">
-                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                    <Parameter id="NyLxljzF9kOBarosioOhrQ" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                     </Parameter>
-                    <Parameter id="RsBBEqI2YEadgQhCOR2VcA" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" isDefault="1">
+                    <Parameter id="PvQ6bEYX_0Ch7E8_vLq4cQ" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="dipEL4GfNEijtKQHXMZyfQ" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" isDefault="1">
+                    <Parameter id="-vba9UMNTkWnqKeX5M2Gzg" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="aK1VuLKqN0WjZvUzz3VClw" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" isDefault="1">
+                    <Parameter id="8_B4bW6L5UCmRKR-IqWCqA" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="OtGhP9rS-EWpMJci-r7QKQ" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" isDefault="1">
+                    <Parameter id="KBRdAh2kck6bW-oflDRrJw" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="qxWS_YSaM0qLTx1WjneOBw" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" isDefault="1">
+                    <Parameter id="5iuZKGv6_U23tUvbDMMytQ" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="d_05VRbOiES_KmaIadjo5g" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
-                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                    <Parameter id="MXDUDye3KEG9LdVtE4UQ8w" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="wPOJ7ACqi0GOnZi4YnqNUQ" name="Oral mass absorbed segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" rHSFormula="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_uje" value="0" displayUnit="µmol">
-                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                    <Parameter id="_W1vXxYMoEaUVqJYxbMEdg" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="zbZG70R8FEmLN9Hx-MJjzA" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" isDefault="1">
+                    <Parameter id="qw8wBBDYWEiGXxr8jBy7Hw" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="8yZfklSmV0i50oPcZAaeHA" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" isDefault="1">
+                    <Parameter id="23iEPEpJ4EmHzbR2dLZ1QQ" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="9PZN_iGWFkqg_Ln_YCRvVQ" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal_GI" isDefault="1">
-                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                    <Parameter id="tLmuKKQvSky-u-xvKUQ1qQ" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="UxTKsJx9tECSeJ0iJFdb-w" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" isDefault="1">
+                    <Parameter id="Fv7ChTr0ikSmJf2Z2Csnnw" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="T-9BEazMZE2y8x3i77olbg" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
-                      <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                    <Parameter id="W8fSWX2VpUeEKVL5m7Kajg" name="Solubility" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_IntestinalSolubility" isDefault="1" displayUnit="mg/l">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="42" />
+                    </Parameter>
+                    <Parameter id="huGmW8LjyEy7DP1ihfUJDg" name="Solubility table" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.TableFormulaWithXArgument_SolubilityTable" isDefault="1" displayUnit="mg/l">
+                      <Info min="0" flag="50" seq="1" ref="0" bb="2" group="42" />
                     </Parameter>
-                    <Parameter id="eJjxj-rE_kC4wp_7vVZPbg" name="Solubility_pKa_pH_Factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" isDefault="1">
+                    <Parameter id="2yJ9dkDROE2A-w_hI0kn5Q" name="Solubility_pKa_pH_Factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="qQdkvefdyE-WiUmXafLSeA" name="Solubility table" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.TableFormulaWithXArgument_SolubilityTable" isDefault="1" displayUnit="mg/l">
-                      <Info min="0" flag="50" seq="1" ref="0" bb="2" group="42" />
+                    <Parameter id="EQVSCkWegE-AUiULmQ0PPw" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                      <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                     </Parameter>
-                    <Parameter id="Ach0zJPmy0Co-ar72hE9FQ" name="Solubility" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_IntestinalSolubility" isDefault="1" displayUnit="mg/l">
-                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="42" />
+                    <Parameter id="NsJd0-_7cEeZ-37i5HXBgQ" name="Effective concentration in lumen" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_EffectiveLumenConcentration" isDefault="1" displayUnit="µmol/l">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="42" />
                     </Parameter>
                   </Children>
                 </Container>
               </Children>
             </Container>
-            <Container id="harsFHy1eEiQ-1kDQvZx5g" name="LowerJejunum" mode="Physical" containerType="Compartment">
+            <Container id="Ngf59qCHkEOYMMJTcfumlw" name="LowerJejunum" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="Lumen" />
                 <Tag value="LumenSegment" />
               </Tags>
               <Children>
-                <Parameter id="1xkJIxu4H06wLf42BgZ2oA" name="Proximal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R1" isDefault="1" displayUnit="cm">
+                <Parameter id="9SHoCtNtX0ehiw426up9xA" name="Absorption of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Outflow_LowerJejunum" isDefault="1" displayUnit="1/min">
+                  <Info flag="54" seq="1" ref="0" bb="2" group="63" />
+                </Parameter>
+                <Parameter id="8mmgF5M4902xj0VaAbEerA" name="Distal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R2" isDefault="1" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="uB9yz4usikKhXD7C6VIEYg" name="Secretion of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Inflow_LowerJejunum" isDefault="1" displayUnit="l/min">
-                  <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
-                </Parameter>
-                <Parameter id="15GSfQGKs06FlrkwcsP0Fg" name="Thickness of gut wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Thickness" isDefault="1" displayUnit="cm">
+                <Parameter id="jwmhx2KpiECdy6wjAnjwUg" name="Effective surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_EffectiveSurfaceArea" isDefault="1" displayUnit="cm²">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="38" seq="1" ref="0" bb="32" group="45" />
+                  <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
+                  <Info min="0" flag="52" seq="1" ref="0" bb="32" group="33" />
                 </Parameter>
-                <Parameter id="Q4ndCax-wkOrzL0Yv4jH5g" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_LumenSegment" isDefault="1" displayUnit="l">
-                  <Info min="0" flag="62" seq="1" ref="0" bb="2" group="56" />
+                <Parameter id="FhnkHfmBKUCo6W72id25ag" name="FillLevelFlag" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevelFlagFlag" isDefault="1">
+                  <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                </Parameter>
+                <Parameter id="rGFDv_pSeUeH3tsyNaDpqQ" name="Fraction of geometric volume filled with liquid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevel" isDefault="1">
+                  <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="UD6MTUUKak-qBnDqPgd1jA" name="Volume (gut wall)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="MucosaVolume_Human.PARAM_VolumeGutWall_LowerJejunum" isDefault="1" displayUnit="l">
+                <Parameter id="cyO7xlRr80WPb6crJ0BFiQ" name="Geometric surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Area" isDefault="1" displayUnit="cm²">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="62" seq="1" ref="0" bb="32" group="44" />
+                  <Info min="0" flag="62" seq="1" ref="0" bb="32" group="33" />
+                </Parameter>
+                <Parameter id="_srpO30ZAUazWDgcEgFezQ" name="Intestinal transit rate (absolute)" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_InverseSITT_Factor_LowerJejunum" isDefault="1" displayUnit="1/min">
+                  <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="iZKnbSp2nUC5uZmaI8BBIw" name="Length" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Length" isDefault="1" displayUnit="cm">
+                <Parameter id="ZMAPQA4nck28d7CrsKYOVA" name="Length" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Length" isDefault="1" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info min="0" flag="106" seq="1" ref="0" bb="32" group="34" />
                 </Parameter>
-                <Parameter id="gnIIDHz35kagsfEZLzMvkg" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
-                  <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
-                </Parameter>
-                <Parameter id="snp2GtwnnEGgi3_HKNFTIA" name="Liquid transfer rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_LiquidTransferRate_lje" isDefault="1" displayUnit="l/min">
-                  <Info flag="52" seq="1" ref="0" bb="2" group="39" />
-                </Parameter>
-                <Parameter id="d74W8Be5yEaQRlsQ7aeFIA" name="Liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Liquid_StartValue" isDefault="1" rHSFormula="Lumen_PKSim.LiquidRHS_lje" displayUnit="l">
+                <Parameter id="9dI-pgdJDE2kxL1ywU5PEA" name="Liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Liquid_StartValue" isDefault="1" rHSFormula="Lumen_PKSim.LiquidRHS_lje" displayUnit="l">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="e-MUlEaobUqqdGSB18-E0w" name="Absorption of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Outflow_LowerJejunum" isDefault="1" displayUnit="1/min">
-                  <Info flag="54" seq="1" ref="0" bb="2" group="63" />
+                <Parameter id="XTH2DuQr-0a-uL0c7S1XXw" name="Liquid transfer rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_LiquidTransferRate_lje" isDefault="1" displayUnit="l/min">
+                  <Info flag="52" seq="1" ref="0" bb="2" group="39" />
                 </Parameter>
-                <Parameter id="43oA5axYZEugKNrKDt-yAw" name="Distal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R2" isDefault="1" displayUnit="cm">
+                <Parameter id="pLeTKHTDKESXJs7xDmPrPQ" name="Proximal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R1" isDefault="1" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="YFdTRt62NU2HpuGsOh6KwA" name="Effective surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_EffectiveSurfaceArea" isDefault="1" displayUnit="cm²">
+                <Parameter id="6hJI3RZvRUSaf37YqRDflA" name="Secretion of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Inflow_LowerJejunum" isDefault="1" displayUnit="l/min">
+                  <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                </Parameter>
+                <Parameter id="esiXEHIYsUqe01zFzliNdw" name="Thickness of gut wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Thickness" isDefault="1" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
-                  <Info min="0" flag="52" seq="1" ref="0" bb="32" group="33" />
-                </Parameter>
-                <Parameter id="0CgRVox4pUuPteLahY0UkA" name="FillLevelFlag" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevelFlagFlag" isDefault="1">
-                  <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                  <Info min="0" flag="38" seq="1" ref="0" bb="32" group="45" />
                 </Parameter>
-                <Parameter id="X-P5bat30UeU9tOlf0KpiA" name="Fraction of geometric volume filled with liquid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevel" isDefault="1">
-                  <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                <Parameter id="tbbSD2f9gk24vvoIMdsIlw" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_LumenSegment" isDefault="1" displayUnit="l">
+                  <Info min="0" flag="62" seq="1" ref="0" bb="2" group="56" />
                 </Parameter>
-                <Parameter id="zwFgo1-ea0C_tEZpFOCqHQ" name="Geometric surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Area" isDefault="1" displayUnit="cm²">
+                <Parameter id="ATVyQt3BNEmITSJCEg-4uw" name="Volume (gut wall)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="MucosaVolume_Human.PARAM_VolumeGutWall_LowerJejunum" isDefault="1" displayUnit="l">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="62" seq="1" ref="0" bb="32" group="33" />
+                  <Info min="0" flag="62" seq="1" ref="0" bb="32" group="44" />
                 </Parameter>
-                <Parameter id="9nDchB8a6Ea7kQG5xBlQbA" name="Intestinal transit rate (absolute)" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_InverseSITT_Factor_LowerJejunum" isDefault="1" displayUnit="1/min">
-                  <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                <Parameter id="zNUh3ROq50OJODr0cgc6ug" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                  <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                 </Parameter>
-                <Parameter id="QrgbVSqy90CN-EBy5yumZQ" name="Thickness_p3" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.30703115" displayUnit="1/cm">
+                <Parameter id="GyKXVgErx0eDgsNNN7lNRg" name="Fractional steady state fill level" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.064841">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                  <Info min="0" flag="58" seq="1" ref="0" bb="32" group="43" />
                 </Parameter>
-                <Parameter id="7KIGk2MCv0y8-1Y6f280Bg" name="L_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.299751712">
+                <Parameter id="TV-GBvPhoU-_KRCEcewQew" name="Intestinal transit rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="5.0162" displayUnit="1/min">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="34" />
+                  <Info min="0" flag="54" seq="1" ref="0" bb="32" group="46" />
                 </Parameter>
-                <Parameter id="5ya3IbHuKU21LGojTwT6Bg" name="Thickness_p2" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0465856499" displayUnit="cm">
+                <Parameter id="aR23VGAAB0Sy56BSxPDkzg" name="L_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0670329582" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="34" />
                 </Parameter>
-                <Parameter id="qvDDrepQEEGtcUdbcYZVfg" name="Thickness_p1" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0196976609" displayUnit="cm">
+                <Parameter id="Gtb1KZVQ2UKMCQSLuM8i_w" name="L_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.299751712">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="34" />
                 </Parameter>
-                <Parameter id="cq8rwh95IE2lnHtMjXd0jw" name="r2_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.008101398">
+                <Parameter id="fhQLGbnnu06WR4PlKXsvoQ" name="Microvilli factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="25">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                  <Info min="0" flag="38" seq="1" ref="0" bb="32" group="33" />
                 </Parameter>
-                <Parameter id="22v4rHoKxEWoWQP3wcdpHQ" name="r2_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0018117016" displayUnit="cm">
+                <Parameter id="GJLNWHycSUeKTyDqZWLYzQ" name="r1_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0019411088" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="BqMlqe-7b02TtpR_q_X2OA" name="r1_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.008680069">
+                <Parameter id="vudlYt6IXUyDdgW3Q6Ol7Q" name="r1_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.008680069">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="nYfJ4T_RF0ulqn9TtgQbsw" name="Microvilli factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="25">
+                <Parameter id="Sym85CJqo02nmf_zeyRtXg" name="r2_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0018117016" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="38" seq="1" ref="0" bb="32" group="33" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="EsLqf0wLUUaHrFQPez5_MQ" name="L_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0670329582" displayUnit="cm">
+                <Parameter id="3gFf33ZrC06TEGGZ2yObpA" name="r2_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.008101398">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="34" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="kVfB_BmXz0izVuDyzpdYSw" name="Intestinal transit rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="5.0162" displayUnit="1/min">
+                <Parameter id="Kr6cKSCouEig0cHbTih_RQ" name="Thickness_p1" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0196976609" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="54" seq="1" ref="0" bb="32" group="46" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
                 </Parameter>
-                <Parameter id="m3F5RWHOS02GuXwkkUhsew" name="Fractional steady state fill level" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.064841">
+                <Parameter id="6uDasIFooUqsHbMZsRgUyg" name="Thickness_p2" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0465856499" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="58" seq="1" ref="0" bb="32" group="43" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
                 </Parameter>
-                <Parameter id="VS2usYqZAEmD116-eDeiVw" name="r1_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0019411088" displayUnit="cm">
+                <Parameter id="72zLud8RmUGCO8L48fFwTw" name="Thickness_p3" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.30703115" displayUnit="1/cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
                 </Parameter>
-                <Parameter id="Z8yFa01RbEeV97JzDYiLkQ" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="6.9167">
+                <Parameter id="1OlSailPNECE8CY2so_b8Q" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="6.9167">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
@@ -4582,12 +4608,12 @@
                   <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
                   <Info min="0" max="14" flag="122" seq="1" ref="0" bb="32" group="41" />
                 </Parameter>
-                <DistributedParameter id="kqy37Os_40m1g-8VSMz8Sg" name="Effective surface area enhancement factor" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="icJJansS5UCaY6D-jZ1Exw" mode="Logical" isDefault="1">
+                <DistributedParameter id="jVbefod87kKK9SdAv5U5-w" name="Effective surface area enhancement factor" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="bmUpPkHFXEmZ0j8FgsU_gA" mode="Logical" isDefault="1">
                   <Children>
-                    <Parameter id="DQxE-8w36UGgYTO6BG1a0Q" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                    <Parameter id="gh-thGfPMkOG1GcVtIf8BA" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
                       <Info min="0" flag="18" seq="1" ref="0" bb="32" group="32" />
                     </Parameter>
-                    <Parameter id="g6pFRsHcMUaWi5aV_igH9w" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="372.9358">
+                    <Parameter id="mvIWi66ZTUu4Yz8TppzmZQ" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="372.9358">
                       <Info min="0" flag="50" seq="1" ref="0" bb="32" group="32" />
                     </Parameter>
                   </Children>
@@ -4597,90 +4623,86 @@
                   </Tags>
                   <Info min="0" flag="122" seq="1" ref="0" bb="32" group="32" />
                 </DistributedParameter>
-                <Container id="9psesTf8aU2BwL9kgDC4pw" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="L44b4tamfkiBKz8DmepNKg" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                   <Children>
-                    <Parameter id="K9RGYxDuPUCiXE-dZh7PqA" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" isDefault="1">
-                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
-                    </Parameter>
-                    <Parameter id="_oojIDL_XU2DKaZg0gnWfg" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal_GI" isDefault="1">
+                    <Parameter id="Edc5bpzJ3U2chO2FgwGQCQ" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal_GI" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                     </Parameter>
-                    <Parameter id="x0ArED3xJ0a1ThoZKbGj4w" name="Oral mass absorbed segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" rHSFormula="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_lje" value="0" displayUnit="µmol">
+                    <Parameter id="Aa3cVznQPkGa7hxjiCPElA" name="Oral mass absorbed segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" rHSFormula="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_lje" value="0" displayUnit="µmol">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                     </Parameter>
-                    <Parameter id="6NM9xd5fS06Cvvg0JJEQ4A" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                    <Parameter id="wBoEvp0XH0y_Bt2hOGnndA" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                     </Parameter>
-                    <Parameter id="OdEnfL0ZdUqkhRZD02ShoQ" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" isDefault="1">
+                    <Parameter id="rqbiok9s-EmAGezpcj6Gng" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                    </Parameter>
+                    <Parameter id="JAgw0qHO-kSMjOfo5XPL4A" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="dEcigBjBZE-XUKPpmuXzJw" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" isDefault="1">
+                    <Parameter id="SND2ms63bEWOZfXkx1I49g" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="xBkGBfduGkaTV6nZMIsG7w" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" isDefault="1">
+                    <Parameter id="wg_Iet_cjUC0uBsVZs6fQQ" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="MNzdRAWevkO06pi9IB0ghg" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" isDefault="1">
+                    <Parameter id="Gv-949i5R0maHRLqDDg6AA" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="zZ1rIE6Bq0mzVIhnrWfx1g" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" isDefault="1">
+                    <Parameter id="jEuAL7tAaUOueXNDfyLZRA" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="O4OvAy3qrE2OrehClK8SGA" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" isDefault="1">
+                    <Parameter id="pw31SLe7U0KkR-tZZdA5Lw" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="Pb9k6vNn0k6xEcb60mjRRA" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" isDefault="1">
+                    <Parameter id="7ITwiRx4Q06nKEvdAOdd2A" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="MFg3ejJRqkCRodkj1vU2hQ" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" isDefault="1">
+                    <Parameter id="agQeweguLUWrXJT_Oa8R_Q" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="KwjXASYtXEa1thsjuKF8OA" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" isDefault="1">
+                    <Parameter id="9t_KZykpk0Cg49UAcMu7vA" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="PKt-Hx-X-0mOwsaXLLAgMQ" name="Solubility" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_IntestinalSolubility" isDefault="1" displayUnit="mg/l">
+                    <Parameter id="IXTw55Cjo02kCQCNIcwACw" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                    </Parameter>
+                    <Parameter id="GYkxQ_YAykONf9Dtd0w3pQ" name="Solubility" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_IntestinalSolubility" isDefault="1" displayUnit="mg/l">
                       <Info min="0" flag="122" seq="1" ref="0" bb="2" group="42" />
                     </Parameter>
-                    <Parameter id="XqRJ8mycXUieP7uj0pdBVQ" name="Solubility table" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.TableFormulaWithXArgument_SolubilityTable" isDefault="1" displayUnit="mg/l">
+                    <Parameter id="z9EreqK3p0yH0igmjfWFzw" name="Solubility table" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.TableFormulaWithXArgument_SolubilityTable" isDefault="1" displayUnit="mg/l">
                       <Info min="0" flag="50" seq="1" ref="0" bb="2" group="42" />
                     </Parameter>
-                    <Parameter id="-lT0qcvaOkyKyveBXEzaoQ" name="Solubility_pKa_pH_Factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" isDefault="1">
+                    <Parameter id="R7x_JjvpF0Ohpy4k3XAJTQ" name="Solubility_pKa_pH_Factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="G3UkCuNrcU29fEGqgwG7sA" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                    <Parameter id="tdrWhNFKR0OGNKBg9RqJmg" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
                       <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                     </Parameter>
-                    <Parameter id="cSU0q888ykOtzG1y8kzW0A" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" isDefault="1">
-                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                    <Parameter id="opAgolZcrkuQi47hqrdYhw" name="Effective concentration in lumen" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_EffectiveLumenConcentration" isDefault="1" displayUnit="µmol/l">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="42" />
                     </Parameter>
                   </Children>
                 </Container>
               </Children>
             </Container>
-            <Container id="Ihg_wnyKDky6HlnEBLVT1A" name="UpperIleum" mode="Physical" containerType="Compartment">
+            <Container id="YontS4KffU69B65vcA06_A" name="UpperIleum" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="Lumen" />
                 <Tag value="LumenSegment" />
               </Tags>
               <Children>
-                <Parameter id="c_UKx8BBgEONin50Sj7tww" name="Distal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R2" isDefault="1" displayUnit="cm">
-                  <Tags>
-                    <Tag value="Lumen" />
-                    <Tag value="LumenSegment" />
-                  </Tags>
-                  <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
+                <Parameter id="FM5vNIosS0uwXG6eg2eLdw" name="Absorption of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Outflow_UpperIleum" isDefault="1" displayUnit="1/min">
+                  <Info flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="hMSrBRLDTEyOhzNdfgZelA" name="Proximal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R1" isDefault="1" displayUnit="cm">
+                <Parameter id="dxgTnpjBWUq0Sk2zSthVzQ" name="Distal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R2" isDefault="1" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="IK3WE9ieDk6YkprERr7R6w" name="Absorption of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Outflow_UpperIleum" isDefault="1" displayUnit="1/min">
-                  <Info flag="54" seq="1" ref="0" bb="2" group="63" />
-                </Parameter>
-                <Parameter id="I-DA0VQRW065Eo1PtHhU3A" name="Effective surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_EffectiveSurfaceArea" isDefault="1" displayUnit="cm²">
+                <Parameter id="6NzGsUeHs0StcOACbljgJA" name="Effective surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_EffectiveSurfaceArea" isDefault="1" displayUnit="cm²">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
@@ -4688,143 +4710,150 @@
                   <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
                   <Info min="0" flag="52" seq="1" ref="0" bb="32" group="33" />
                 </Parameter>
-                <Parameter id="DyacAF-1JEqtIYz-U-r5dw" name="FillLevelFlag" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevelFlagFlag" isDefault="1">
+                <Parameter id="RN5FaVctv0e8buVkB7nUxQ" name="FillLevelFlag" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevelFlagFlag" isDefault="1">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="b-na8qxq40KKEm__2NGm1Q" name="Fraction of geometric volume filled with liquid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevel" isDefault="1">
+                <Parameter id="soQRuh2560adAPcj2M-FSQ" name="Fraction of geometric volume filled with liquid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevel" isDefault="1">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="WyOnnuhWNUmM_Fq1kd5nyw" name="Geometric surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Area" isDefault="1" displayUnit="cm²">
+                <Parameter id="6l5hyh7rD0KRpZGPl38Bog" name="Geometric surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Area" isDefault="1" displayUnit="cm²">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info min="0" flag="62" seq="1" ref="0" bb="32" group="33" />
                 </Parameter>
-                <Parameter id="S-5h4aMsVEGpDOrvNFuhEA" name="Intestinal transit rate (absolute)" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_InverseSITT_Factor_UpperIleum" isDefault="1" displayUnit="1/min">
+                <Parameter id="yxP6EGSn3ka2oUf34FZyMA" name="Intestinal transit rate (absolute)" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_InverseSITT_Factor_UpperIleum" isDefault="1" displayUnit="1/min">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="dnkyQPfTm0WrL_X1tFT90Q" name="Length" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Length" isDefault="1" displayUnit="cm">
+                <Parameter id="8UqKBVZuNkuOXFnKZa1P0g" name="Length" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Length" isDefault="1" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info min="0" flag="106" seq="1" ref="0" bb="32" group="34" />
                 </Parameter>
-                <Parameter id="prZxgh54_k6wM4arP3MdHQ" name="Liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Liquid_StartValue" isDefault="1" rHSFormula="Lumen_PKSim.LiquidRHS_uil" displayUnit="l">
-                  <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
-                </Parameter>
-                <Parameter id="Z6llU-SRvkiXc1LFn4T13g" name="Secretion of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Inflow_UpperIleum" isDefault="1" displayUnit="l/min">
+                <Parameter id="6AWyl6G_ZEWdeqAwi06ubQ" name="Liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Liquid_StartValue" isDefault="1" rHSFormula="Lumen_PKSim.LiquidRHS_uil" displayUnit="l">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="YgcLCr6jmEeIjtxWCEaouw" name="Liquid transfer rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_LiquidTransferRate_uil" isDefault="1" displayUnit="l/min">
+                <Parameter id="iPkstbtWi0KjIM6BgaftHg" name="Liquid transfer rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_LiquidTransferRate_uil" isDefault="1" displayUnit="l/min">
                   <Info flag="52" seq="1" ref="0" bb="2" group="39" />
                 </Parameter>
-                <Parameter id="-kScjc_tA02haCR7DyLOtw" name="Thickness of gut wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Thickness" isDefault="1" displayUnit="cm">
+                <Parameter id="F1aAZkIibUKyvnLb1WfHHw" name="Proximal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R1" isDefault="1" displayUnit="cm">
+                  <Tags>
+                    <Tag value="Lumen" />
+                    <Tag value="LumenSegment" />
+                  </Tags>
+                  <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
+                </Parameter>
+                <Parameter id="d3YIBDFSP0-Uzhd0rHIyWg" name="Secretion of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Inflow_UpperIleum" isDefault="1" displayUnit="l/min">
+                  <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                </Parameter>
+                <Parameter id="BP5dgrA_uUORbyZttK8Udw" name="Thickness of gut wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Thickness" isDefault="1" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info min="0" flag="38" seq="1" ref="0" bb="32" group="45" />
                 </Parameter>
-                <Parameter id="9idM3Gt4mkGGmBtolSc0BQ" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_LumenSegment" isDefault="1" displayUnit="l">
+                <Parameter id="ObJLovwUgkSQNlk5zdAwaw" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_LumenSegment" isDefault="1" displayUnit="l">
                   <Info min="0" flag="62" seq="1" ref="0" bb="2" group="56" />
                 </Parameter>
-                <Parameter id="61p60wwt4U-153UnKQAqwA" name="Volume (gut wall)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="MucosaVolume_Human.PARAM_VolumeGutWall_UpperIleum" isDefault="1" displayUnit="l">
+                <Parameter id="EeN8fwcAOkOHIdEngooFoA" name="Volume (gut wall)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="MucosaVolume_Human.PARAM_VolumeGutWall_UpperIleum" isDefault="1" displayUnit="l">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info min="0" flag="62" seq="1" ref="0" bb="32" group="44" />
                 </Parameter>
-                <Parameter id="pBQt3uRpD0Kl7pCBCCRKFg" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                <Parameter id="0_nMTY_4P067r3uuqRrt-Q" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
                   <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                 </Parameter>
-                <Parameter id="MJJR1EHs7U2PxEqEe7izBw" name="r2_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0015528871" displayUnit="cm">
+                <Parameter id="HGtWxHpWXka3h4a8S0uJag" name="Fractional steady state fill level" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.064841">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                  <Info min="0" flag="58" seq="1" ref="0" bb="32" group="43" />
                 </Parameter>
-                <Parameter id="3q-Jp6PcwkudCrs7zgjCaQ" name="Thickness_p3" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.30703115" displayUnit="1/cm">
+                <Parameter id="jm5MWxnfvkO5u2NYgE36KA" name="Intestinal transit rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="3.3745" displayUnit="1/min">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                  <Info min="0" flag="54" seq="1" ref="0" bb="32" group="46" />
                 </Parameter>
-                <Parameter id="_g1C1q-AU0qzxJ9lWzW4IQ" name="Thickness_p2" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.061552122" displayUnit="cm">
+                <Parameter id="9trfX4_dZ0GMgt4j274NPg" name="L_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0996435866" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="34" />
                 </Parameter>
-                <Parameter id="iW2nfEfaGE-NL7ploNEXoQ" name="r2_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.006944055">
+                <Parameter id="p-195L1C1ESIbUabXoX1bw" name="L_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.445576869">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="34" />
                 </Parameter>
-                <Parameter id="1yZwpi_7VU6LzuKTqrOLEw" name="r1_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.008101398">
+                <Parameter id="DZtow83qGEGGAnkp7UFIvw" name="Microvilli factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="25">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                  <Info min="0" flag="38" seq="1" ref="0" bb="32" group="33" />
                 </Parameter>
-                <Parameter id="3Q4Elh1w_02k0cNqX-pa6A" name="r1_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0018117016" displayUnit="cm">
+                <Parameter id="IEFdcyYfCk2Dfo-upadXlQ" name="r1_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0018117016" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="aN8NPoeFBEOAlMkiV3-VaA" name="Microvilli factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="25">
+                <Parameter id="_ibQyUQw00SK5W41s8JowQ" name="r1_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.008101398">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="38" seq="1" ref="0" bb="32" group="33" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="sSEFJ5u8Lk2Ibw1hHxzT8g" name="L_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.445576869">
+                <Parameter id="MFDzEz3Oo0yq3OBh1m6DYQ" name="r2_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0015528871" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="34" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="XbiDhbAlukaogLqdcF0A2w" name="L_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0996435866" displayUnit="cm">
+                <Parameter id="uo3VxQ9RCUOyIlmkQ9JBFg" name="r2_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.006944055">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="34" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="c0Em3qAkr0OpJ657jTeLOw" name="Intestinal transit rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="3.3745" displayUnit="1/min">
+                <Parameter id="rPaSNPl9mUOJEwU900WyOA" name="Thickness_p1" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0260258863" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="54" seq="1" ref="0" bb="32" group="46" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
                 </Parameter>
-                <Parameter id="6RKWkBDQhEiUoBe8gVhLhg" name="Thickness_p1" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0260258863" displayUnit="cm">
+                <Parameter id="z1d4wnQl_kaVul5Oy5VkDw" name="Thickness_p2" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.061552122" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info flag="54" seq="1" ref="0" bb="32" group="45" />
                 </Parameter>
-                <Parameter id="ilE4fySP20WqTohOR3ulqw" name="Fractional steady state fill level" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.064841">
+                <Parameter id="-9O6nLwXNU-FNqG4am-Nzw" name="Thickness_p3" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.30703115" displayUnit="1/cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="58" seq="1" ref="0" bb="32" group="43" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
                 </Parameter>
-                <Parameter id="eE0uGNDASU-3XsxokoHODg" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.2083">
+                <Parameter id="RoOmMiMTJ0ef3l13NgK5mg" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.2083">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
@@ -4832,12 +4861,12 @@
                   <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
                   <Info min="0" max="14" flag="122" seq="1" ref="0" bb="32" group="41" />
                 </Parameter>
-                <DistributedParameter id="z8mhcv6J8ESp-96Q0STUng" name="Effective surface area enhancement factor" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="kCW7DHSXwEaTNkf9TPpAkg" mode="Logical" isDefault="1">
+                <DistributedParameter id="6EoH3vAU0UOdjD32Qb_ntQ" name="Effective surface area enhancement factor" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="YH842VUX3kaECpoyXhsQWA" mode="Logical" isDefault="1">
                   <Children>
-                    <Parameter id="cWv3jOyTEEGmJyZI_mqGfA" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                    <Parameter id="YEJx96b15keFe8RgYg3ndA" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
                       <Info min="0" flag="18" seq="1" ref="0" bb="32" group="32" />
                     </Parameter>
-                    <Parameter id="RbFiy8Mm2kia4-1WN9PWog" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="260.7527">
+                    <Parameter id="pHOslL0Wo0WWRnbKAVn1fw" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="260.7527">
                       <Info min="0" flag="50" seq="1" ref="0" bb="32" group="32" />
                     </Parameter>
                   </Children>
@@ -4847,99 +4876,86 @@
                   </Tags>
                   <Info min="0" flag="122" seq="1" ref="0" bb="32" group="32" />
                 </DistributedParameter>
-                <Container id="pmJUKPlcf0KPOkBu1zh4Rg" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="k8VXUfmlpEOdJ-Xo0qfAQA" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                   <Children>
-                    <Parameter id="4Bd-lIQBfk6x2SsurKpjZQ" name="Solubility_pKa_pH_Factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" isDefault="1">
-                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="18" />
+                    <Parameter id="g5vSQLtubUS30KZpMYCyVw" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal_GI" isDefault="1">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                     </Parameter>
-                    <Parameter id="O8rZkbvV1UiPXTJRzZFUfg" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
-                      <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                    <Parameter id="TMbmB_cpNUCq5u8uyRgfvg" name="Oral mass absorbed segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" rHSFormula="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_uil" value="0" displayUnit="µmol">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                     </Parameter>
-                    <Parameter id="D3ee1EWI_Ee7RqGrXGEMpA" name="Solubility table" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.TableFormulaWithXArgument_SolubilityTable" isDefault="1" displayUnit="mg/l">
-                      <Info min="0" flag="50" seq="1" ref="0" bb="2" group="42" />
+                    <Parameter id="nyGitlOnsEiwFuO_WMiNlw" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                     </Parameter>
-                    <Parameter id="IZd2CsN2IUuhzSU98mjG9w" name="Solubility" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_IntestinalSolubility" isDefault="1" displayUnit="mg/l">
-                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="42" />
+                    <Parameter id="f12NZCiMnEOMB8kYBAKt8Q" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="QKH_KAKn6EGNXd7K246-uw" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" isDefault="1">
+                    <Parameter id="OhpQghsfWU2Grq3jslx_zA" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="Sy3gs5w4r0muBmI_8HXgNQ" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" isDefault="1">
+                    <Parameter id="35nUXjNhckOgnaBHK6YGSw" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="8lWbwwrkbkyYrDzcLTX45A" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" isDefault="1">
+                    <Parameter id="O2fV08N91UW0kzqkf4zvfQ" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="FXuqGHKzukWocVEB55EVsA" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" isDefault="1">
+                    <Parameter id="pq5DROzAA0eyrKeL9l4UOg" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="rdsRBq7AbUiGBBskMfYmvQ" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" isDefault="1">
+                    <Parameter id="TCwUdcZT_0CIAzwt5ngCLw" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="r7yDMPjNSE-L4G8VfupHeg" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" isDefault="1">
+                    <Parameter id="FrbPONl8bk-us-7KPdx9DQ" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="Fh0kR1kwYUOtMMzVmVv9qQ" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" isDefault="1">
+                    <Parameter id="YobRDsqwlU-jFN7Ec3F0pQ" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="-6sTq_eCv0Sz1XzVy2ov8Q" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" isDefault="1">
+                    <Parameter id="YKYkkdl6yUSqXlRiRNI6vg" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="YorIAD00R06oz_jdQp08lQ" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" isDefault="1">
+                    <Parameter id="3nRzZzvowEyQ51k_foO7rQ" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="S5uvwF0x9kGJFkTEA1Ly2Q" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal_GI" isDefault="1">
-                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                    <Parameter id="XuxOIn77bkOnIkryHzPeeQ" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="KAvAS4cmD0K-wdGF7JEUnw" name="Oral mass absorbed segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" rHSFormula="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_uil" value="0" displayUnit="µmol">
-                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                    <Parameter id="DDMJNmE1w0y6v6y8U1TcZQ" name="Solubility" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_IntestinalSolubility" isDefault="1" displayUnit="mg/l">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="42" />
                     </Parameter>
-                    <Parameter id="Pta_t4pntUOhAzw-HEzMXw" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
-                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                    <Parameter id="00BehkUg8UyxMaknDKMBZw" name="Solubility table" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.TableFormulaWithXArgument_SolubilityTable" isDefault="1" displayUnit="mg/l">
+                      <Info min="0" flag="50" seq="1" ref="0" bb="2" group="42" />
                     </Parameter>
-                    <Parameter id="26ei8xGPYEi23wnDK6xkDQ" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" isDefault="1">
-                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                    <Parameter id="YzcCeOzWAEuFgaPt3Dqb9Q" name="Solubility_pKa_pH_Factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" isDefault="1">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="Xp59mwaTnkqU2KmpYXTOsg" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" isDefault="1">
-                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                    <Parameter id="fIU5sZSmU06FmFVGR9q3xA" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                      <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                    </Parameter>
+                    <Parameter id="hoBeM3Bb402iw9hxw0aZOA" name="Effective concentration in lumen" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_EffectiveLumenConcentration" isDefault="1" displayUnit="µmol/l">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="42" />
                     </Parameter>
                   </Children>
                 </Container>
               </Children>
             </Container>
-            <Container id="eM1zn7TZCkyCHMf6OsbM0Q" name="LowerIleum" mode="Physical" containerType="Compartment">
+            <Container id="C_Q1ZtRcwUSAmwuymmvd1A" name="LowerIleum" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="Lumen" />
                 <Tag value="LumenSegment" />
               </Tags>
               <Children>
-                <Parameter id="QfNf9b9s5Ei_t9CbHA4f1w" name="Volume (gut wall)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="MucosaVolume_Human.PARAM_VolumeGutWall_LowerIleum" isDefault="1" displayUnit="l">
-                  <Tags>
-                    <Tag value="Lumen" />
-                    <Tag value="LumenSegment" />
-                  </Tags>
-                  <Info min="0" flag="62" seq="1" ref="0" bb="32" group="44" />
-                </Parameter>
-                <Parameter id="VKbtUUQPZUSyoQao9jSyAw" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
-                  <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                <Parameter id="sdXqpg_jb0-0WOcLZ5oecw" name="Absorption of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Outflow_LowerIleum" isDefault="1" displayUnit="1/min">
+                  <Info flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="DwwOJSNtnUSUlaY3zQ9ENA" name="Thickness of gut wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Thickness" isDefault="1" displayUnit="cm">
+                <Parameter id="OocJzuCyw0G3vWNZ4z7iFA" name="Distal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R2" isDefault="1" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="38" seq="1" ref="0" bb="32" group="45" />
-                </Parameter>
-                <Parameter id="2roMHhULyUKDIsxLpd5Jag" name="FillLevelFlag" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevelFlagFlag" isDefault="1">
-                  <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
-                </Parameter>
-                <Parameter id="yrxypklRjEmYbxAb3uufag" name="Absorption of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Outflow_LowerIleum" isDefault="1" displayUnit="1/min">
-                  <Info flag="54" seq="1" ref="0" bb="2" group="63" />
-                </Parameter>
-                <Parameter id="XHngFBFaikuOvz5xfocODw" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_LumenSegment" isDefault="1" displayUnit="l">
-                  <Info min="0" flag="62" seq="1" ref="0" bb="2" group="56" />
+                  <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="3qnHWAiUdk6M6tkmjpp5Hg" name="Effective surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_EffectiveSurfaceArea" isDefault="1" displayUnit="cm²">
+                <Parameter id="vBruSswD7EOsPyCYcDXJHA" name="Effective surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_EffectiveSurfaceArea" isDefault="1" displayUnit="cm²">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
@@ -4947,147 +4963,163 @@
                   <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
                   <Info min="0" flag="52" seq="1" ref="0" bb="32" group="33" />
                 </Parameter>
-                <Parameter id="O21K7u3YYUKVb0BVxWsmmQ" name="Fraction of geometric volume filled with liquid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevel" isDefault="1">
+                <Parameter id="PIZ-96JF0UCTKpemK7Px4Q" name="FillLevelFlag" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevelFlagFlag" isDefault="1">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="1wO-cp_7oUuPg8C-ABr-Ww" name="Geometric surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Area" isDefault="1" displayUnit="cm²">
+                <Parameter id="lSZS3UUPCE6OeIgwxcKdgw" name="Fraction of geometric volume filled with liquid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevel" isDefault="1">
+                  <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                </Parameter>
+                <Parameter id="gq-sLp13FUWa6bjqmlTUrg" name="Geometric surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Area" isDefault="1" displayUnit="cm²">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info min="0" flag="62" seq="1" ref="0" bb="32" group="33" />
                 </Parameter>
-                <Parameter id="gxkZk_IyCU6kiXgknnkwvA" name="Intestinal transit rate (absolute)" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_InverseSITT_Factor_LowerIleum" isDefault="1" displayUnit="1/min">
+                <Parameter id="UblTdOSrO0iz6rBCrHHfhg" name="Intestinal transit rate (absolute)" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_InverseSITT_Factor_LowerIleum" isDefault="1" displayUnit="1/min">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="7KDcYCi8-Eevs4Wb3vOMiQ" name="Length" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Length" isDefault="1" displayUnit="cm">
+                <Parameter id="ZtzD5dfVvkunOyNYfQSsqA" name="Length" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Length" isDefault="1" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info min="0" flag="106" seq="1" ref="0" bb="32" group="34" />
                 </Parameter>
-                <Parameter id="SOWgqwC_GkC59iBXc1cphQ" name="Liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Liquid_StartValue" isDefault="1" rHSFormula="Lumen_PKSim.LiquidRHS_lil" displayUnit="l">
+                <Parameter id="AxL8QVAALkK29utBR8wWSQ" name="Liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Liquid_StartValue" isDefault="1" rHSFormula="Lumen_PKSim.LiquidRHS_lil" displayUnit="l">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="E0VvSYnAGUi9HfrM3qhPXw" name="Liquid transfer rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_LiquidTransferRate_lil" isDefault="1" displayUnit="l/min">
+                <Parameter id="3aDEgr1hYEGEbgJ2exCTmQ" name="Liquid transfer rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_LiquidTransferRate_lil" isDefault="1" displayUnit="l/min">
                   <Info flag="52" seq="1" ref="0" bb="2" group="39" />
                 </Parameter>
-                <Parameter id="Y2FfIriQrE6T-2JNSjeZGA" name="Proximal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R1" isDefault="1" displayUnit="cm">
+                <Parameter id="Ki9d8pyxYkKXjdGypdAnZQ" name="Proximal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R1" isDefault="1" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="tKhhPBc6502YoCfi_YcjUw" name="Secretion of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Inflow_LowerIleum" isDefault="1" displayUnit="l/min">
+                <Parameter id="oNpKLTccuEK8X4J76kSkSg" name="Secretion of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Inflow_LowerIleum" isDefault="1" displayUnit="l/min">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="zeplrry5HEOZ40btHQqcZw" name="Distal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R2" isDefault="1" displayUnit="cm">
+                <Parameter id="vyPik9CJE0arVFvIL_pb2w" name="Thickness of gut wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Thickness" isDefault="1" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
+                  <Info min="0" flag="38" seq="1" ref="0" bb="32" group="45" />
                 </Parameter>
-                <Parameter id="Ws8IShyzrk6VjCINDTzJaw" name="Intestinal transit rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="3.3745" displayUnit="1/min">
+                <Parameter id="CW3H_CLtm0eG23vX9SQtIw" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_LumenSegment" isDefault="1" displayUnit="l">
+                  <Info min="0" flag="62" seq="1" ref="0" bb="2" group="56" />
+                </Parameter>
+                <Parameter id="VqjvmJrHWUCEn-NUpMfg3g" name="Volume (gut wall)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="MucosaVolume_Human.PARAM_VolumeGutWall_LowerIleum" isDefault="1" displayUnit="l">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="54" seq="1" ref="0" bb="32" group="46" />
+                  <Info min="0" flag="62" seq="1" ref="0" bb="32" group="44" />
                 </Parameter>
-                <Parameter id="XShVO60WuUS9ymCMlFT9YA" name="Fractional steady state fill level" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.064841">
+                <Parameter id="R4mD1shVF0aAIBuqGs2S_A" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                  <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                </Parameter>
+                <Parameter id="hBQVxni79U2sW2oNuml_YQ" name="Fractional steady state fill level" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.064841">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info min="0" flag="58" seq="1" ref="0" bb="32" group="43" />
                 </Parameter>
-                <Parameter id="WT1VuirCEEmUgCbjO-Mbkw" name="Microvilli factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="25">
+                <Parameter id="f3qV6gO3PE-_GnhJChHZLQ" name="Intestinal transit rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="3.3745" displayUnit="1/min">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="38" seq="1" ref="0" bb="32" group="33" />
+                  <Info min="0" flag="54" seq="1" ref="0" bb="32" group="46" />
                 </Parameter>
-                <Parameter id="SPMZnNGh00Sc396v58fW5w" name="Thickness_p1" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0148137399" displayUnit="cm">
+                <Parameter id="KXO0cEsyH0qt3EKhM3n6uA" name="L_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0996435866" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="34" />
                 </Parameter>
-                <Parameter id="7yC8K90ctEySBnwyVfq4YQ" name="L_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0996435866" displayUnit="cm">
+                <Parameter id="IUkcAVkikUSw85luCUjBvg" name="L_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.445576869">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info flag="54" seq="1" ref="0" bb="32" group="34" />
                 </Parameter>
-                <Parameter id="ZebgALHXeUS4jykKSdpPIw" name="Thickness_p2" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0350288649" displayUnit="cm">
+                <Parameter id="d_Fw32PZVEKheIy-HVoplA" name="Microvilli factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="25">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                  <Info min="0" flag="38" seq="1" ref="0" bb="32" group="33" />
                 </Parameter>
-                <Parameter id="ql0WQmo5MU6EHgdLpwpnBg" name="L_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.445576869">
+                <Parameter id="UrjsSM6pjk-f9QeEHglIZQ" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.4583">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="34" />
+                  <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
+                  <Info min="0" max="14" flag="122" seq="1" ref="0" bb="32" group="41" />
                 </Parameter>
-                <Parameter id="dASDr94LW0qv2mcqi7_4qQ" name="r2_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.005786713">
+                <Parameter id="y_N7n5HzIke0M8sgNkY8Qg" name="r1_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0015528871" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="wmd9_WnLk0OERARWnRuolg" name="r2_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0012940725" displayUnit="cm">
+                <Parameter id="NnHDDDL_Y0iHifv50rqgiQ" name="r1_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.006944055">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="JxaoyMjDDUKcOIvhjuAraA" name="r1_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.006944055">
+                <Parameter id="whAA2h4jn0O9BTApS5eGwg" name="r2_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0012940725" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="t6Q1s1SsokC75aPq1R64fA" name="r1_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0015528871" displayUnit="cm">
+                <Parameter id="BdA-DcY3mEOTzh4CyoIwCQ" name="r2_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.005786713">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="MsMPIU_Wu0OV8gh5L8mkwQ" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.4583">
+                <Parameter id="VJDICfuklkGei-Y4Gqj0RA" name="Thickness_p1" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0148137399" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
-                  <Info min="0" max="14" flag="122" seq="1" ref="0" bb="32" group="41" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                </Parameter>
+                <Parameter id="rB61KoJdQ02ImWyHOhuEfA" name="Thickness_p2" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0350288649" displayUnit="cm">
+                  <Tags>
+                    <Tag value="Lumen" />
+                    <Tag value="LumenSegment" />
+                  </Tags>
+                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
                 </Parameter>
-                <Parameter id="a3Gp0yBJpUGRu4Pu8I8H4Q" name="Thickness_p3" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.30705627" displayUnit="1/cm">
+                <Parameter id="doj97Old7EqSdlpvriTcXQ" name="Thickness_p3" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.30705627" displayUnit="1/cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info flag="54" seq="1" ref="0" bb="32" group="45" />
                 </Parameter>
-                <DistributedParameter id="pYDJ5DP6zUuMq_05gy3zMQ" name="Effective surface area enhancement factor" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="u6g9stHZW0qKVw34740SVQ" mode="Logical" isDefault="1">
+                <DistributedParameter id="9k_t6aXxFECXe1n2gOH-GA" name="Effective surface area enhancement factor" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="OsyX4TuIf0Gm8C-5nxs-Sg" mode="Logical" isDefault="1">
                   <Children>
-                    <Parameter id="uxV72Z5g30ac4cQ18-NtmA" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                    <Parameter id="CXWpQ7B_b0yGnxHY5qY90A" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
                       <Info min="0" flag="18" seq="1" ref="0" bb="32" group="32" />
                     </Parameter>
-                    <Parameter id="oHrfv_fkOkuUGDbOJUfdoA" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="146.565">
+                    <Parameter id="gxc6_S9G4U6TpN8Uj9bosg" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="146.565">
                       <Info min="0" flag="50" seq="1" ref="0" bb="32" group="32" />
                     </Parameter>
                   </Children>
@@ -5097,99 +5129,86 @@
                   </Tags>
                   <Info min="0" flag="122" seq="1" ref="0" bb="32" group="32" />
                 </DistributedParameter>
-                <Container id="kiXg9D2RzEmOyluw7KJ0Ug" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="blWHhotAoUCpYO5pjPr1pQ" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                   <Children>
-                    <Parameter id="S9ZiPmK-TkWpzGFR5L7qww" name="Solubility table" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.TableFormulaWithXArgument_SolubilityTable" isDefault="1" displayUnit="mg/l">
-                      <Info min="0" flag="50" seq="1" ref="0" bb="2" group="42" />
-                    </Parameter>
-                    <Parameter id="tF0ctFe-NkqbLCCmNlpZtA" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" isDefault="1">
-                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
-                    </Parameter>
-                    <Parameter id="YpsTQr_AAEe44u46-N_TRw" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal_GI" isDefault="1">
+                    <Parameter id="PyhUMh-eyEyxbqbzvs6QuQ" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal_GI" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                     </Parameter>
-                    <Parameter id="OKtCsw8DLUmmH8kU511NQQ" name="Oral mass absorbed segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" rHSFormula="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_lil" value="0" displayUnit="µmol">
+                    <Parameter id="IUnaBUswKUW9tQwnk0IX8w" name="Oral mass absorbed segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" rHSFormula="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_lil" value="0" displayUnit="µmol">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                     </Parameter>
-                    <Parameter id="DaKbs35POEW9RIdA29yaYQ" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
-                      <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                    <Parameter id="ns3IFtlZAE-Xdq1FJ_Q9vw" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                     </Parameter>
-                    <Parameter id="IXCmI968r0m79v7f7krqtA" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" isDefault="1">
+                    <Parameter id="-KqlGAcdnEm-cOcDucNmWw" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="OEXJG8LSdkWRLgPCv1frQQ" name="Solubility_pKa_pH_Factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" isDefault="1">
-                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="18" />
+                    <Parameter id="YuGJ4r4AT0-Z1i5-gvVIrQ" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="46BCHVnbD0mKo8j8ScSVog" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" isDefault="1">
+                    <Parameter id="u8puBcpHQ0qDN7LK5PAPIA" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="B9jAq-WkUEafJ4AElzNt3g" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" isDefault="1">
+                    <Parameter id="Ap-O35F6hkazHgYj_SIBUA" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="Hq_cP6FCoEOOgFbtmh7WkQ" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" isDefault="1">
+                    <Parameter id="_k54OniWQ0Wz4c2qzgzXBg" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="LzBKkLe9WUOzGotDiNVIuA" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" isDefault="1">
+                    <Parameter id="8c-byLBQw0GAS8DBCoAtwQ" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="ohW-P2WMREyIn6xoEc-8kQ" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" isDefault="1">
+                    <Parameter id="v5DgWqYvwEKVFG6RMbvwCg" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="LyB6cVjUW0uWk5NV50HP5g" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" isDefault="1">
+                    <Parameter id="caswH9QhhUa-Ip5dTlsqEw" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="o3rzY0zElUWwvrILIQ60cg" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" isDefault="1">
+                    <Parameter id="USN89ovbeke1rzpUZe7PMA" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="9OWhTezikUOwpdy5XYcf4w" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" isDefault="1">
+                    <Parameter id="OMGYWuYIAU6VpG9uz75yNA" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="59_F3Kp4WU6EOx7TVtWmyg" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" isDefault="1">
+                    <Parameter id="_P3NwJeFU02kjgC6ANqdlw" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="fU5z4xH82U6eM88UkuZCfw" name="Solubility" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_IntestinalSolubility" isDefault="1" displayUnit="mg/l">
+                    <Parameter id="O8LiKIWPfEyrhzU4aUJP5A" name="Solubility" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_IntestinalSolubility" isDefault="1" displayUnit="mg/l">
                       <Info min="0" flag="122" seq="1" ref="0" bb="2" group="42" />
                     </Parameter>
-                    <Parameter id="RL8MQxxmwU6CFQsvVId9gA" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
-                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                    <Parameter id="qvJpcf5c5U2noePfFdgERw" name="Solubility table" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.TableFormulaWithXArgument_SolubilityTable" isDefault="1" displayUnit="mg/l">
+                      <Info min="0" flag="50" seq="1" ref="0" bb="2" group="42" />
+                    </Parameter>
+                    <Parameter id="KEHLUzAYS0Spx5lTv4egCw" name="Solubility_pKa_pH_Factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" isDefault="1">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="18" />
+                    </Parameter>
+                    <Parameter id="hVAWpQsc8UKDbHKX3NWF7A" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                      <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                    </Parameter>
+                    <Parameter id="UtrPlEAjZUykHHmURHCdqA" name="Effective concentration in lumen" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_EffectiveLumenConcentration" isDefault="1" displayUnit="µmol/l">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="42" />
                     </Parameter>
                   </Children>
                 </Container>
               </Children>
             </Container>
-            <Container id="g73FHixAbke8T8DjmH5heQ" name="Caecum" mode="Physical" containerType="Compartment">
+            <Container id="YtQbk7tJX0SRGBH7l7Mvow" name="Caecum" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="Lumen" />
                 <Tag value="LumenSegment" />
               </Tags>
               <Children>
-                <Parameter id="tg4mRTQifEaxoz8-YWl_Sw" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
-                  <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
-                </Parameter>
-                <Parameter id="Yt9zJwhbKUWD_cSdCBSCEQ" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_LumenSegment" isDefault="1" displayUnit="l">
-                  <Info min="0" flag="62" seq="1" ref="0" bb="2" group="56" />
+                <Parameter id="psLpJcODV0yIcK0zjfM0aw" name="Absorption of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Outflow_Caecum" isDefault="1" displayUnit="1/min">
+                  <Info flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="DQLYfTRqhkiimQ8zzgyo3Q" name="Volume (gut wall)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="MucosaVolume_Human.PARAM_VolumeGutWall_Caecum" isDefault="1" displayUnit="l">
+                <Parameter id="AJIeaHM8KEulmDvq3j0WLg" name="Distal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R2" isDefault="1" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="62" seq="1" ref="0" bb="32" group="44" />
-                </Parameter>
-                <Parameter id="GdPKfUPa6EWBOXCCoRmTZA" name="Intestinal transit rate (absolute)" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_InverseLITT_Factor_Caecum" isDefault="1" displayUnit="1/min">
-                  <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                  <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="Sy5P1li-jkC-WfWa2eeWjg" name="Absorption of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Outflow_Caecum" isDefault="1" displayUnit="1/min">
-                  <Info flag="54" seq="1" ref="0" bb="2" group="63" />
-                </Parameter>
-                <Parameter id="TVtoHHp3pEWA8_sZsQOvPQ" name="Distal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R2" isDefault="1" displayUnit="cm">
-                  <Tags>
-                    <Tag value="Lumen" />
-                    <Tag value="LumenSegment" />
-                  </Tags>
-                  <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
-                </Parameter>
-                <Parameter id="LGnDPzomgEKGGNUJHXh_QQ" name="Effective surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_EffectiveSurfaceArea" isDefault="1" displayUnit="cm²">
+                <Parameter id="q1TojEE-G0KrqpLHDjABJQ" name="Effective surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_EffectiveSurfaceArea" isDefault="1" displayUnit="cm²">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
@@ -5197,134 +5216,150 @@
                   <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
                   <Info min="0" flag="52" seq="1" ref="0" bb="32" group="33" />
                 </Parameter>
-                <Parameter id="WHBMhDRyW0icKPccs7XwCw" name="FillLevelFlag" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevelFlagFlag" isDefault="1">
+                <Parameter id="HnngX514MEeD1u4jzmhOrw" name="FillLevelFlag" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevelFlagFlag" isDefault="1">
+                  <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                </Parameter>
+                <Parameter id="7LDybeiho0Otuht3jc6S4w" name="Fraction of geometric volume filled with liquid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevel" isDefault="1">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="nt6rVoCduEm_dSj4Svqypg" name="Geometric surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Area" isDefault="1" displayUnit="cm²">
+                <Parameter id="HNfoN4TJxEqhe4BkFzk-6g" name="Geometric surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Area" isDefault="1" displayUnit="cm²">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info min="0" flag="62" seq="1" ref="0" bb="32" group="33" />
                 </Parameter>
-                <Parameter id="9eM__ipfMkaM_dYWlxpGDQ" name="Length" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Length" isDefault="1" displayUnit="cm">
+                <Parameter id="v_HWesFIvEeB-bDz1DctaA" name="Intestinal transit rate (absolute)" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_InverseLITT_Factor_Caecum" isDefault="1" displayUnit="1/min">
+                  <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                </Parameter>
+                <Parameter id="Gv3FFeTMlE6922g-l4NjOg" name="Length" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Length" isDefault="1" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info min="0" flag="106" seq="1" ref="0" bb="32" group="34" />
                 </Parameter>
-                <Parameter id="9vdVMdi8iEiw4lTj1fyBNw" name="Liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Liquid_StartValue" isDefault="1" rHSFormula="Lumen_PKSim.LiquidRHS_cae" displayUnit="l">
+                <Parameter id="hk4TfFeLSkSEnh_bsykNKQ" name="Liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Liquid_StartValue" isDefault="1" rHSFormula="Lumen_PKSim.LiquidRHS_cae" displayUnit="l">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="l5lqp8qnb0Woah9J6EfDVw" name="Liquid transfer rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_LiquidTransferRate_cae" isDefault="1" displayUnit="l/min">
+                <Parameter id="vWBS9KGCkEqIkCDCv5Ssew" name="Liquid transfer rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_LiquidTransferRate_cae" isDefault="1" displayUnit="l/min">
                   <Info flag="52" seq="1" ref="0" bb="2" group="39" />
                 </Parameter>
-                <Parameter id="voveQFfMQEihi0QG_tRmzA" name="Proximal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R1" isDefault="1" displayUnit="cm">
+                <Parameter id="qwnCAAMD5EqQQiXbim9uyg" name="Proximal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R1" isDefault="1" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="kz__QbMUUE6LuTSdUXzVwA" name="Secretion of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Inflow_Caecum" isDefault="1" displayUnit="l/min">
+                <Parameter id="4XggsUeX006okXK2C_8Y5g" name="Secretion of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Inflow_Caecum" isDefault="1" displayUnit="l/min">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="n51565WUKEmL0QL9Af2lGg" name="Thickness of gut wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Thickness" isDefault="1" displayUnit="cm">
+                <Parameter id="XXb4X31uXUWcinDBLnnPVQ" name="Thickness of gut wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Thickness" isDefault="1" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info min="0" flag="38" seq="1" ref="0" bb="32" group="45" />
                 </Parameter>
-                <Parameter id="ENGefbpaV0i28AwX1HZl3Q" name="Fraction of geometric volume filled with liquid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevel" isDefault="1">
-                  <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                <Parameter id="xInyulMcPEOpnKcRZC0WfA" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_LumenSegment" isDefault="1" displayUnit="l">
+                  <Info min="0" flag="62" seq="1" ref="0" bb="2" group="56" />
                 </Parameter>
-                <Parameter id="WfAEZ7tpdUGQDc7qL_HtJQ" name="r1_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.015672726">
+                <Parameter id="eofwqTrYN0SgKBcqIdFVqw" name="Volume (gut wall)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="MucosaVolume_Human.PARAM_VolumeGutWall_Caecum" isDefault="1" displayUnit="l">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                  <Info min="0" flag="62" seq="1" ref="0" bb="32" group="44" />
+                </Parameter>
+                <Parameter id="wBZpta13pkWRHZh0E1oAng" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                  <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                 </Parameter>
-                <Parameter id="X7X5DOap90qHbRW-aaf-8g" name="Thickness_p3" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0897885" displayUnit="1/cm">
+                <Parameter id="98zeA58UhUuXPNgZaD4S6A" name="Fractional steady state fill level" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0060009">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                  <Info min="0" flag="58" seq="1" ref="0" bb="32" group="43" />
                 </Parameter>
-                <Parameter id="kMpUR-PYKEGlPcNTIt6lYA" name="Thickness_p2" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0446435379" displayUnit="cm">
+                <Parameter id="TPVJk4C5w02gI-Nd7xvkpA" name="Intestinal transit rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="18.3333" displayUnit="1/min">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                  <Info min="0" flag="54" seq="1" ref="0" bb="32" group="46" />
                 </Parameter>
-                <Parameter id="6krjBL9nqkKGEMPEKLknYQ" name="Thickness_p1" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.00877" displayUnit="cm">
+                <Parameter id="in-3ofQJ70WcKM6w4U02rQ" name="L_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.1152851235" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="34" />
                 </Parameter>
-                <Parameter id="ROJkv7-lOU2dUwgmSGkxnw" name="r2_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.015672726">
+                <Parameter id="EokduGiS1EGXa-AOBgQLYg" name="L_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.026864843">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="34" />
+                </Parameter>
+                <Parameter id="pskefDJ5VEaYkrvBdaQD3Q" name="Microvilli factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                  <Tags>
+                    <Tag value="Lumen" />
+                    <Tag value="LumenSegment" />
+                  </Tags>
+                  <Info min="0" flag="38" seq="1" ref="0" bb="32" group="33" />
                 </Parameter>
-                <Parameter id="SBPt0QUSxk6rut9BqUFtAA" name="r1_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.067256381" displayUnit="cm">
+                <Parameter id="1ev-dv-D_ki0z0Rcyg-dIA" name="r1_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.067256381" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="XZYpUuDfuUuH9SIYF1Z9xA" name="r2_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.067256381" displayUnit="cm">
+                <Parameter id="628GxooIxEOKRUFSGalrrw" name="r1_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.015672726">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="5FDHSqTSk06qwGbVIPYtOQ" name="Microvilli factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                <Parameter id="mesaHDo6dUuAQ4TW3_NRQw" name="r2_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.067256381" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="38" seq="1" ref="0" bb="32" group="33" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="j1T1R0QH7ECWG2tq5M4-sw" name="L_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.026864843">
+                <Parameter id="2ol9BvKW_0qxjJ-o9v3gLg" name="r2_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.015672726">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="34" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="k8IIlsnZ5UOltPstE0J19A" name="L_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.1152851235" displayUnit="cm">
+                <Parameter id="Xuezn-U7f0ynbbZsriBm8g" name="Thickness_p1" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.00877" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="34" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
                 </Parameter>
-                <Parameter id="7EVEE_kXVk62mV-IvbRakQ" name="Intestinal transit rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="18.3333" displayUnit="1/min">
+                <Parameter id="oo1_Mrzh_kSkzdPOoNW1Lw" name="Thickness_p2" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0446435379" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="54" seq="1" ref="0" bb="32" group="46" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
                 </Parameter>
-                <Parameter id="hPM63cmOckGFHYKNz_2d3g" name="Fractional steady state fill level" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0060009">
+                <Parameter id="cuPQo0LCNk6RQDPIpn8lug" name="Thickness_p3" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0897885" displayUnit="1/cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="58" seq="1" ref="0" bb="32" group="43" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
                 </Parameter>
-                <Parameter id="y8Us76PemUuujXRI_MLUNw" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="5.7">
+                <Parameter id="StRVkoq2dUq3cidrR7bQTw" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="5.7">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
@@ -5332,12 +5367,12 @@
                   <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
                   <Info min="0" max="14" flag="122" seq="1" ref="0" bb="32" group="41" />
                 </Parameter>
-                <DistributedParameter id="mxlnTTVokk-jGCg-cWydSQ" name="Effective surface area enhancement factor" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="l1pN37mH00GJD3ne3YJscg" mode="Logical" isDefault="1">
+                <DistributedParameter id="M6AlsxYzQ024Y7XFsv-oxA" name="Effective surface area enhancement factor" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="j4P3e2FcIEqEZrgkqcPrww" mode="Logical" isDefault="1">
                   <Children>
-                    <Parameter id="GmsLz0o_lUyPF9ePgUH0CQ" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                    <Parameter id="Y3rVnINUiU-MCHnKvG-FGA" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
                       <Info min="0" flag="18" seq="1" ref="0" bb="32" group="32" />
                     </Parameter>
-                    <Parameter id="5oLyxRptlkCcO1AzmqUEzQ" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.8">
+                    <Parameter id="MPxTy-lnEE26IEOcwOIx-Q" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.8">
                       <Info min="0" flag="50" seq="1" ref="0" bb="32" group="32" />
                     </Parameter>
                   </Children>
@@ -5347,96 +5382,86 @@
                   </Tags>
                   <Info min="0" flag="122" seq="1" ref="0" bb="32" group="32" />
                 </DistributedParameter>
-                <Container id="XmF4qolDxE-8qw9hIDwo1A" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="-TEYbufWhUGzgldFmDE1Hw" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                   <Children>
-                    <Parameter id="yMCQLZNAS0SAXa76pFZlDg" name="Oral mass absorbed segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" rHSFormula="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_cae" value="0" displayUnit="µmol">
-                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                    <Parameter id="MkNfNahlU0SV5HUPKYcOkA" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal_GI" isDefault="1">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                     </Parameter>
-                    <Parameter id="lq3ga4K9tkO8q9xHH_0wWw" name="Solubility" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_IntestinalSolubility" isDefault="1" displayUnit="mg/l">
-                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="42" />
+                    <Parameter id="rEXV3nuTakSVe0QaZbx2wA" name="Oral mass absorbed segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" rHSFormula="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_cae" value="0" displayUnit="µmol">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                     </Parameter>
-                    <Parameter id="gzxUgVaHPU62hQ62iKPxKQ" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                    <Parameter id="HBQX2Qho4E2aiaDNOQBBZQ" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                     </Parameter>
-                    <Parameter id="LjQZYo0uJ0Ga3-YTvgH3ag" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" isDefault="1">
+                    <Parameter id="-5L2nJ9OZ0C4xfsVh5hiOw" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="8zdi5R8AHEmC0rJZGx1rrw" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" isDefault="1">
+                    <Parameter id="XUPMQRNkZk2EuW1m0zJxCQ" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="WWSylO9y2EW9gY8Q-iMbEw" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" isDefault="1">
+                    <Parameter id="fve7PORPO0WFEbw86-BKvg" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="FxqERyA_z0W0vjWlvBksfw" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" isDefault="1">
+                    <Parameter id="vUVbRJZRUkK8fqdDMqCMDg" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="zVm2KmBsEEuqzlgZV3RXlA" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" isDefault="1">
+                    <Parameter id="VSIl7TQud06yWfjEJJRTcw" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="sv6IlTlLnUilNYMGUFv5Og" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" isDefault="1">
+                    <Parameter id="1DW9BVakqkqoJNozzRreQw" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="ZS6SO9kJ0kWaF-aNCmnynA" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" isDefault="1">
+                    <Parameter id="O5k2O5Los0-VYRpMupxI2A" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="NyrYq9DocUCdj09XxTkJsA" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" isDefault="1">
+                    <Parameter id="yBkgR6QA-EqcWFTKGAG2QQ" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="u0YMEj_Zw0CjtEWfrF9KiA" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" isDefault="1">
+                    <Parameter id="SFpYRm_hykqHND-mtPDtZA" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="ty3nwIr-UkOSpnS69xBL_w" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" isDefault="1">
+                    <Parameter id="vntUaifviUeeCpt_ba90iw" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="RjZhUaYgU0uIof8odkZyKQ" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal_GI" isDefault="1">
-                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                    <Parameter id="8_BuVXe8U0ijBH2banGZdg" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                    </Parameter>
+                    <Parameter id="saXuRd2_aUKR-jmuLBYVYA" name="Solubility" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_IntestinalSolubility" isDefault="1" displayUnit="mg/l">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="42" />
                     </Parameter>
-                    <Parameter id="LOV9y3zpWkWFUEXL8ADf4Q" name="Solubility table" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.TableFormulaWithXArgument_SolubilityTable" isDefault="1" displayUnit="mg/l">
+                    <Parameter id="0_GDBHuLqU2Ke64SM3HcvQ" name="Solubility table" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.TableFormulaWithXArgument_SolubilityTable" isDefault="1" displayUnit="mg/l">
                       <Info min="0" flag="50" seq="1" ref="0" bb="2" group="42" />
                     </Parameter>
-                    <Parameter id="HyQ_zadvhkC6m7Glw8Y2Rw" name="Solubility_pKa_pH_Factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" isDefault="1">
+                    <Parameter id="KlCL4I9e0UaQfANbsQc2EA" name="Solubility_pKa_pH_Factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="mtJM9qpHHkOLhz_mEgezGA" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                    <Parameter id="zmnEreVsrUO5hS9nnfAQcQ" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
                       <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                     </Parameter>
-                    <Parameter id="bGJA-9-KJEeg9dmRQJ1RVw" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" isDefault="1">
-                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                    <Parameter id="BWb4SygGUEmqL4j1Sctq0w" name="Effective concentration in lumen" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_EffectiveLumenConcentration" isDefault="1" displayUnit="µmol/l">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="42" />
                     </Parameter>
                   </Children>
                 </Container>
               </Children>
             </Container>
-            <Container id="alASnwRuBk-kXDoH0sPohw" name="ColonAscendens" mode="Physical" containerType="Compartment">
+            <Container id="IIG08bkIP0mqw9u39eWCjA" name="ColonAscendens" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="Lumen" />
                 <Tag value="LumenSegment" />
               </Tags>
               <Children>
-                <Parameter id="2Baq7JZsfU-QXMuMH1s6Iw" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
-                  <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
-                </Parameter>
-                <Parameter id="SSKPcOjuCUGUatFtgmzYgA" name="Volume (gut wall)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="MucosaVolume_Human.PARAM_VolumeGutWall_ColonAscendens" isDefault="1" displayUnit="l">
-                  <Tags>
-                    <Tag value="Lumen" />
-                    <Tag value="LumenSegment" />
-                  </Tags>
-                  <Info min="0" flag="62" seq="1" ref="0" bb="32" group="44" />
-                </Parameter>
-                <Parameter id="efW4l0BDykWblB2TlIQZzg" name="Liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Liquid_StartValue" isDefault="1" rHSFormula="Lumen_PKSim.LiquidRHS_colasc" displayUnit="l">
-                  <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
-                </Parameter>
-                <Parameter id="eTbdVa9xmkeH8Xl5akZarg" name="Absorption of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Outflow_ColonAscendens" isDefault="1" displayUnit="1/min">
+                <Parameter id="qfMmsUwdJkqn6lOXhlFDsQ" name="Absorption of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Outflow_ColonAscendens" isDefault="1" displayUnit="1/min">
                   <Info flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="XHDHpz4rjkW80PIXlJp5uQ" name="Distal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R2" isDefault="1" displayUnit="cm">
+                <Parameter id="yDBtkXTou0GIE8XshK9nPA" name="Distal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R2" isDefault="1" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="BrniTM32PUmdYpVRzPSE_w" name="Effective surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_EffectiveSurfaceArea" isDefault="1" displayUnit="cm²">
+                <Parameter id="Fm8krVj6Wk6rshwXYxjN7w" name="Effective surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_EffectiveSurfaceArea" isDefault="1" displayUnit="cm²">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
@@ -5444,150 +5469,163 @@
                   <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
                   <Info min="0" flag="52" seq="1" ref="0" bb="32" group="33" />
                 </Parameter>
-                <Parameter id="OFUmwfL5mEyn7O3vEDZ31w" name="FillLevelFlag" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevelFlagFlag" isDefault="1">
+                <Parameter id="n6VnKj_y1EK8wjzrHHiJ5A" name="FillLevelFlag" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevelFlagFlag" isDefault="1">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="c91q0vbcnkSCv-eJmrl9rA" name="Fraction of geometric volume filled with liquid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevel" isDefault="1">
+                <Parameter id="2oYxZTOu5kOzCqIoKTfSCA" name="Fraction of geometric volume filled with liquid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevel" isDefault="1">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="0KSFAkrEn0q4jLQJFVULqw" name="Geometric surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Area" isDefault="1" displayUnit="cm²">
+                <Parameter id="n8-i8EHk-0KiGC3MwB-agg" name="Geometric surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Area" isDefault="1" displayUnit="cm²">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info min="0" flag="62" seq="1" ref="0" bb="32" group="33" />
                 </Parameter>
-                <Parameter id="CPNP-9uAR0ilvYd7ULw69A" name="Length" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Length" isDefault="1" displayUnit="cm">
+                <Parameter id="uNg3BMnduUOQiurptfJgAA" name="Intestinal transit rate (absolute)" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_InverseLITT_Factor_ColonAscendens" isDefault="1" displayUnit="1/min">
+                  <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                </Parameter>
+                <Parameter id="vYBXMo_cckyf9M520YJobw" name="Length" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Length" isDefault="1" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info min="0" flag="106" seq="1" ref="0" bb="32" group="34" />
                 </Parameter>
-                <Parameter id="2dlKYJ0ZPkePGdPEf7ebCg" name="Liquid transfer rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_LiquidTransferRate_colasc" isDefault="1" displayUnit="l/min">
+                <Parameter id="oIjoBe-7YkCJB06IPcJ8kA" name="Liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Liquid_StartValue" isDefault="1" rHSFormula="Lumen_PKSim.LiquidRHS_colasc" displayUnit="l">
+                  <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                </Parameter>
+                <Parameter id="tliYlj_TMUGSwTGPBArrUA" name="Liquid transfer rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_LiquidTransferRate_colasc" isDefault="1" displayUnit="l/min">
                   <Info flag="52" seq="1" ref="0" bb="2" group="39" />
                 </Parameter>
-                <Parameter id="2D3oq7UDU0mYFkIiWfEtMQ" name="Proximal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R1" isDefault="1" displayUnit="cm">
+                <Parameter id="r835zvIJEEKsez-3DoNUGA" name="Proximal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R1" isDefault="1" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="lBwnVM5VHkOgjJ3o0Xuvuw" name="Secretion of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Inflow_ColonAscendens" isDefault="1" displayUnit="l/min">
+                <Parameter id="QFNA1TbOLUGnfm06jIB7VA" name="Secretion of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Inflow_ColonAscendens" isDefault="1" displayUnit="l/min">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="VEOA5VVf70ChP1hAxFo7dA" name="Thickness of gut wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Thickness" isDefault="1" displayUnit="cm">
+                <Parameter id="sDGyw_blx0CHtFkv5u2hAA" name="Thickness of gut wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Thickness" isDefault="1" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info min="0" flag="38" seq="1" ref="0" bb="32" group="45" />
                 </Parameter>
-                <Parameter id="4Xb4o2n6LUOROxAX2Xv39Q" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_LumenSegment" isDefault="1" displayUnit="l">
+                <Parameter id="JtZgYo_XmkenWHW2kF5ZIA" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_LumenSegment" isDefault="1" displayUnit="l">
                   <Info min="0" flag="62" seq="1" ref="0" bb="2" group="56" />
                 </Parameter>
-                <Parameter id="MDC-I6n4o0aOpM3bIOhYKg" name="Intestinal transit rate (absolute)" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_InverseLITT_Factor_ColonAscendens" isDefault="1" displayUnit="1/min">
-                  <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                <Parameter id="8aySVHsVEUyPKiMpXXONpQ" name="Volume (gut wall)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="MucosaVolume_Human.PARAM_VolumeGutWall_ColonAscendens" isDefault="1" displayUnit="l">
+                  <Tags>
+                    <Tag value="Lumen" />
+                    <Tag value="LumenSegment" />
+                  </Tags>
+                  <Info min="0" flag="62" seq="1" ref="0" bb="32" group="44" />
+                </Parameter>
+                <Parameter id="AdHINlJ6IEes42mxi5iACQ" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                  <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                 </Parameter>
-                <Parameter id="epQGQqqOkkCxdc6wcw7L1Q" name="Fractional steady state fill level" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0060009">
+                <Parameter id="MYtjG-6MM0i0PgnwxS0jiA" name="Fractional steady state fill level" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0060009">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info min="0" flag="58" seq="1" ref="0" bb="32" group="43" />
                 </Parameter>
-                <Parameter id="s5FKxfL6fk2dLQtNdw3iOQ" name="r1_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.015672726">
+                <Parameter id="K1-2IkXVuEioUvBKW8fbVw" name="Intestinal transit rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="1/min">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                  <Info min="0" flag="54" seq="1" ref="0" bb="32" group="46" />
                 </Parameter>
-                <Parameter id="lRlEnRlpcEy0-J3P_IEjgg" name="r1_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.067256381" displayUnit="cm">
+                <Parameter id="eAIKm7dl2UKjhiMQ_mDiIw" name="L_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.3117189273" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="34" />
                 </Parameter>
-                <Parameter id="5TJqOfNRo0-_TFytIIX5aA" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="5.6">
+                <Parameter id="MD0koibqcEmxnk0RXE7c-Q" name="L_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.075727844">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
-                  <Info min="0" max="14" flag="122" seq="1" ref="0" bb="32" group="41" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="34" />
                 </Parameter>
-                <Parameter id="i9-caIp8zkmxw-BP1Uey8Q" name="Microvilli factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                <Parameter id="MIWwCgzwo0mjO4z7P3qfSw" name="Microvilli factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info min="0" flag="38" seq="1" ref="0" bb="32" group="33" />
                 </Parameter>
-                <Parameter id="S542FcCVikyFJcmWZpUfDQ" name="L_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.075727844">
+                <Parameter id="Rn0SzzHsKUK6fjeHOgXWyg" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="5.6">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="34" />
+                  <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
+                  <Info min="0" max="14" flag="122" seq="1" ref="0" bb="32" group="41" />
                 </Parameter>
-                <Parameter id="y859UV9-ZkOrrGW9JIR00A" name="r2_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.015672726">
+                <Parameter id="KP1wkb04sUurxUJarBQShA" name="r1_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.067256381" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="sloIR4WpFEinJNN8WTLeig" name="Intestinal transit rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="1/min">
+                <Parameter id="NIizCvV4EU-uyEbINjun0g" name="r1_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.015672726">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="54" seq="1" ref="0" bb="32" group="46" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="Mbh5tCXdPES7RFXKEprm0A" name="Thickness_p1" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.00554" displayUnit="cm">
+                <Parameter id="qEMBCmuJ60-5dc0hLMpQvA" name="r2_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.067256381" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="B9FYc5jh0UOrlwupx5QKng" name="L_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.3117189273" displayUnit="cm">
+                <Parameter id="drf9xzvo7ka315FdhOx1ng" name="r2_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.015672726">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="34" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="7e49sXd8r0qExINMuFjSuQ" name="r2_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.067256381" displayUnit="cm">
+                <Parameter id="EhpWJOMu0EuXVfrkL5q2RA" name="Thickness_p1" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.00554" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
                 </Parameter>
-                <Parameter id="vO6sdCmFWUCMjZNyB9iFLQ" name="Thickness_p3" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.09106073" displayUnit="1/cm">
+                <Parameter id="VjzUIPs8JUqet-MHZf2pHA" name="Thickness_p2" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0280138174" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info flag="54" seq="1" ref="0" bb="32" group="45" />
                 </Parameter>
-                <Parameter id="sOKycQa12k2EXpH7zaDUVQ" name="Thickness_p2" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0280138174" displayUnit="cm">
+                <Parameter id="VqsGS8C-3ESGpzzkbL0OPw" name="Thickness_p3" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.09106073" displayUnit="1/cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info flag="54" seq="1" ref="0" bb="32" group="45" />
                 </Parameter>
-                <DistributedParameter id="-xGFutT41UyaDykXVZlipQ" name="Effective surface area enhancement factor" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="59eMMBfo_kmmR-jwAJXeMg" mode="Logical" isDefault="1">
+                <DistributedParameter id="yuJ_RnqFfkGUMve9SO4wTQ" name="Effective surface area enhancement factor" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="AC5U7FD4fU-yu4bGSPdpdg" mode="Logical" isDefault="1">
                   <Children>
-                    <Parameter id="FjhclqPVykiL3Nw7THzplQ" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                    <Parameter id="QRI6NcfaBEuQqVKsGV9yGQ" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
                       <Info min="0" flag="18" seq="1" ref="0" bb="32" group="32" />
                     </Parameter>
-                    <Parameter id="F969GZIsT0eZaMSrDcLxrA" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.5">
+                    <Parameter id="sDQVE8ckPkqijWHnP5kxKw" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.5">
                       <Info min="0" flag="50" seq="1" ref="0" bb="32" group="32" />
                     </Parameter>
                   </Children>
@@ -5597,87 +5635,86 @@
                   </Tags>
                   <Info min="0" flag="122" seq="1" ref="0" bb="32" group="32" />
                 </DistributedParameter>
-                <Container id="iIQRwkKhk0CKdGMHFLL77Q" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="B2fNC3R-Xk-Z-yiaKm5N_Q" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                   <Children>
-                    <Parameter id="IB46cI_MEUG0QumC4ZKYLg" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" isDefault="1">
-                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
-                    </Parameter>
-                    <Parameter id="ZsmKjZ4n2U6MvZy16M0oyg" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" isDefault="1">
-                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
-                    </Parameter>
-                    <Parameter id="VlQjMhWKf0mBs-oclztKDQ" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" isDefault="1">
-                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
-                    </Parameter>
-                    <Parameter id="CUVCEsGyG0CNTnabdunGGg" name="Solubility" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_IntestinalSolubility" isDefault="1" displayUnit="mg/l">
-                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="42" />
-                    </Parameter>
-                    <Parameter id="WMZezitirUuLahX0jnZGLQ" name="Solubility table" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.TableFormulaWithXArgument_SolubilityTable" isDefault="1" displayUnit="mg/l">
-                      <Info min="0" flag="50" seq="1" ref="0" bb="2" group="42" />
+                    <Parameter id="Fd5M7Au2dEKApoj4_0Ut7Q" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal_GI" isDefault="1">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                     </Parameter>
-                    <Parameter id="MMBGf5vn8EKAvhQxBKX2aQ" name="Solubility_pKa_pH_Factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" isDefault="1">
-                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="18" />
+                    <Parameter id="0nUjNv2060mS69RectWYnA" name="Oral mass absorbed segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" rHSFormula="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_colasc" value="0" displayUnit="µmol">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                     </Parameter>
-                    <Parameter id="DTkBefMc5kOV-v6I81YOUQ" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
-                      <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                    <Parameter id="KRE9bRIHP0GqnQs8z27Wlw" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                     </Parameter>
-                    <Parameter id="WuZ3Wwuj1k2aaG49o7ceRg" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" isDefault="1">
+                    <Parameter id="hGySef1RMkqIh8xH-gXXug" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="Oo3TgMdzr0Gih28f6OtP9g" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" isDefault="1">
+                    <Parameter id="kICkwGKMO0-jM_dWLgvoew" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="7JGkApgzjESLrGVCM8zHkg" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" isDefault="1">
+                    <Parameter id="cP9OUZkGYE-Zp7FJaTLiqw" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="PF8KphzTLUutECso99TR2g" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal_GI" isDefault="1">
-                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                    <Parameter id="TRn_SA3gQUGoOu4dH6BYag" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="QFn-arrh4kqqPzRDs6UFiA" name="Oral mass absorbed segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" rHSFormula="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_colasc" value="0" displayUnit="µmol">
-                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                    <Parameter id="w_xIqgu9MUWYPkRntgDn1Q" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="fGLm-fTKC02OVOsrSWk7Bw" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
-                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                    <Parameter id="DqSacPIDSkS053SCngiFbg" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="l48OU_U-mkqu3NOhq4LRzw" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" isDefault="1">
+                    <Parameter id="xJyemQpHl0epL_igtul1pA" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="thYlaB0M20C0ChvlelJ_Ag" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" isDefault="1">
+                    <Parameter id="RXZTen5KykOSnEixXg5bdA" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="_-_sDjWM70S1CXLWqDdsWg" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" isDefault="1">
+                    <Parameter id="a6e-rzHzskml2YmA9NfqWA" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="EGYyJCT0tESENndzNXMA4A" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" isDefault="1">
+                    <Parameter id="B-HEDY722UaC0Oft7-xegQ" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="FiOZWlootkiA_EXG91193g" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" isDefault="1">
+                    <Parameter id="vZmYoWGk7U2y2PF-002NHw" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
+                    <Parameter id="7fCCo4TP4UinFKo9-v371w" name="Solubility" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_IntestinalSolubility" isDefault="1" displayUnit="mg/l">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="42" />
+                    </Parameter>
+                    <Parameter id="vfYhj8sgqk2TT2039DqyDQ" name="Solubility table" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.TableFormulaWithXArgument_SolubilityTable" isDefault="1" displayUnit="mg/l">
+                      <Info min="0" flag="50" seq="1" ref="0" bb="2" group="42" />
+                    </Parameter>
+                    <Parameter id="TDFcaOncgECDr8lT8W6hHQ" name="Solubility_pKa_pH_Factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" isDefault="1">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="18" />
+                    </Parameter>
+                    <Parameter id="UB8P4UHv0k-LVVl9p7-Etg" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                      <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                    </Parameter>
+                    <Parameter id="Cm6eKL_F8EeVMFBpqJ4uzQ" name="Effective concentration in lumen" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_EffectiveLumenConcentration" isDefault="1" displayUnit="µmol/l">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="42" />
+                    </Parameter>
                   </Children>
                 </Container>
               </Children>
             </Container>
-            <Container id="ie3h9CgxCU284p0wLjL9fw" name="ColonTransversum" mode="Physical" containerType="Compartment">
+            <Container id="gOwWT2AqWk2pbTe4eeu9iw" name="ColonTransversum" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="Lumen" />
                 <Tag value="LumenSegment" />
               </Tags>
               <Children>
-                <Parameter id="5N92gONLpkSj8Ujoiy5YYg" name="Proximal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R1" isDefault="1" displayUnit="cm">
-                  <Tags>
-                    <Tag value="Lumen" />
-                    <Tag value="LumenSegment" />
-                  </Tags>
-                  <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
+                <Parameter id="YqYW732GRUGZrUc5jJasEA" name="Absorption of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Outflow_ColonTransversum" isDefault="1" displayUnit="1/min">
+                  <Info flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="uJ9rRWY0vkmc-LQ6nekQkw" name="Distal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R2" isDefault="1" displayUnit="cm">
+                <Parameter id="01EG2-VieUuNeWjQ3tstag" name="Distal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R2" isDefault="1" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="9A2kPN3dS0CZi1Pm98fh8Q" name="Effective surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_EffectiveSurfaceArea" isDefault="1" displayUnit="cm²">
+                <Parameter id="90i5DXuEskysS6YlO_Kbvw" name="Effective surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_EffectiveSurfaceArea" isDefault="1" displayUnit="cm²">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
@@ -5685,159 +5722,163 @@
                   <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
                   <Info min="0" flag="52" seq="1" ref="0" bb="32" group="33" />
                 </Parameter>
-                <Parameter id="svyQEYWEhkCU-C8n8R8vNA" name="FillLevelFlag" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevelFlagFlag" isDefault="1">
+                <Parameter id="fM2DAgLI10i808XL9ShXiQ" name="FillLevelFlag" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevelFlagFlag" isDefault="1">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="mcvagqzGA0mNRwC04VqInA" name="Fraction of geometric volume filled with liquid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevel" isDefault="1">
+                <Parameter id="gVzZqEFRD0qEtOQWFY9w9w" name="Fraction of geometric volume filled with liquid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevel" isDefault="1">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="qAB499JHx0KO7bRetXCRgw" name="Geometric surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Area" isDefault="1" displayUnit="cm²">
+                <Parameter id="hzUGjAh3XEKZZNu4hKL3NQ" name="Geometric surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Area" isDefault="1" displayUnit="cm²">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info min="0" flag="62" seq="1" ref="0" bb="32" group="33" />
                 </Parameter>
-                <Parameter id="bJhkwOPK6E-m_6ZfXDDv4g" name="Intestinal transit rate (absolute)" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_InverseLITT_Factor_ColonTransversum" isDefault="1" displayUnit="1/min">
+                <Parameter id="flMgiUp2HEumsAVXR_UJEQ" name="Intestinal transit rate (absolute)" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_InverseLITT_Factor_ColonTransversum" isDefault="1" displayUnit="1/min">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="y8DcIhXldU-FvtcB8bHJoQ" name="Length" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Length" isDefault="1" displayUnit="cm">
+                <Parameter id="_RgsgtqWZkyKYDWu9wx9Sg" name="Length" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Length" isDefault="1" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info min="0" flag="106" seq="1" ref="0" bb="32" group="34" />
                 </Parameter>
-                <Parameter id="26sg2EEll0yttOWCKrOm0g" name="Liquid transfer rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_LiquidTransferRate_coltrans" isDefault="1" displayUnit="l/min">
+                <Parameter id="XcY5E78EFEikagJLq6c5Bg" name="Liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Liquid_StartValue" isDefault="1" rHSFormula="Lumen_PKSim.LiquidRHS_coltrans" displayUnit="l">
+                  <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                </Parameter>
+                <Parameter id="x4RenH3F20uONTUr8NeuOQ" name="Liquid transfer rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_LiquidTransferRate_coltrans" isDefault="1" displayUnit="l/min">
                   <Info flag="52" seq="1" ref="0" bb="2" group="39" />
                 </Parameter>
-                <Parameter id="bEEjjyHxOUi1Mh6o0ZW0nQ" name="Secretion of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Inflow_ColonTransversum" isDefault="1" displayUnit="l/min">
+                <Parameter id="3WQcd1536kGYMZfUDUvWwA" name="Proximal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R1" isDefault="1" displayUnit="cm">
+                  <Tags>
+                    <Tag value="Lumen" />
+                    <Tag value="LumenSegment" />
+                  </Tags>
+                  <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
+                </Parameter>
+                <Parameter id="9NtSSlfJB0KqPcX19zfe0g" name="Secretion of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Inflow_ColonTransversum" isDefault="1" displayUnit="l/min">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="Rc_ibfzhkku-YUDVn78M9w" name="Thickness of gut wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Thickness" isDefault="1" displayUnit="cm">
+                <Parameter id="Gbf-PVwaqUq1Wb6bR2SuXA" name="Thickness of gut wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Thickness" isDefault="1" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info min="0" flag="38" seq="1" ref="0" bb="32" group="45" />
                 </Parameter>
-                <Parameter id="oSet0CorDkqeAhRg50MUyw" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_LumenSegment" isDefault="1" displayUnit="l">
+                <Parameter id="RjTWHlr-80yv733iyst9fA" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_LumenSegment" isDefault="1" displayUnit="l">
                   <Info min="0" flag="62" seq="1" ref="0" bb="2" group="56" />
                 </Parameter>
-                <Parameter id="YCicGV7I-E-ZKR-Hx3_rtA" name="Volume (gut wall)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="MucosaVolume_Human.PARAM_VolumeGutWall_ColonTransversum" isDefault="1" displayUnit="l">
+                <Parameter id="vS1h1WvRIEyN5N7RWJvmKQ" name="Volume (gut wall)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="MucosaVolume_Human.PARAM_VolumeGutWall_ColonTransversum" isDefault="1" displayUnit="l">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info min="0" flag="62" seq="1" ref="0" bb="32" group="44" />
                 </Parameter>
-                <Parameter id="91uyQrDjVEW5adSXGS0sIQ" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                <Parameter id="2VuDiGvM00qtQLZNtUpS7A" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
                   <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                 </Parameter>
-                <Parameter id="KlCYSRFjbESy_aX-NuwrDg" name="Liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Liquid_StartValue" isDefault="1" rHSFormula="Lumen_PKSim.LiquidRHS_coltrans" displayUnit="l">
-                  <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
-                </Parameter>
-                <Parameter id="niqbdjh1EUaNt5pu33itow" name="Absorption of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Outflow_ColonTransversum" isDefault="1" displayUnit="1/min">
-                  <Info flag="54" seq="1" ref="0" bb="2" group="63" />
-                </Parameter>
-                <Parameter id="KVZed6CKNEyH-f7XPli5Wg" name="Thickness_p2" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0394956146" displayUnit="cm">
+                <Parameter id="q5nFsKPxjEmFa_jhAU5zmw" name="Fractional steady state fill level" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0060009">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                  <Info min="0" flag="58" seq="1" ref="0" bb="32" group="43" />
                 </Parameter>
-                <Parameter id="5ZG-wKVkJ0GqYMrNyhkHEw" name="L_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.144607745">
+                <Parameter id="WgdG4hKqHkS5viLVy3o89A" name="Intestinal transit rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="3.3333" displayUnit="1/min">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="34" />
+                  <Info min="0" flag="54" seq="1" ref="0" bb="32" group="46" />
                 </Parameter>
-                <Parameter id="16Pf7dMR2UOkw9moa1KirA" name="Thickness_p1" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0076" displayUnit="cm">
+                <Parameter id="5Sv5nyXojUCV3elo4Z2M_g" name="L_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.6886041141" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="34" />
                 </Parameter>
-                <Parameter id="jhO3djFKFEq7Tmt4lDi3zA" name="r2_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.008955843">
+                <Parameter id="uopdEJUFjkWUhFY5IWYP8w" name="L_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.144607745">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="34" />
                 </Parameter>
-                <Parameter id="uShG8DtwakePRM1FClmjJg" name="r2_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0384322177" displayUnit="cm">
+                <Parameter id="GJa7qzcgC0GuIPqbv7EzZQ" name="Microvilli factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                  <Info min="0" flag="38" seq="1" ref="0" bb="32" group="33" />
                 </Parameter>
-                <Parameter id="ifeKgw8auUi97ACLNjn_oQ" name="r1_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.015672726">
+                <Parameter id="Dbeeois050ifCUaZRuNFbg" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="5.7">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                  <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
+                  <Info min="0" max="14" flag="122" seq="1" ref="0" bb="32" group="41" />
                 </Parameter>
-                <Parameter id="PZ32FXlwMkSKg3Z16-ndOg" name="r1_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.067256381" displayUnit="cm">
+                <Parameter id="nBQEOGCzrUuWwAeqQ7dO3A" name="r1_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.067256381" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="IYTJP6491UuPv_DknldDxA" name="Microvilli factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                <Parameter id="nWdvSJUMgk-pv5dDASD8hw" name="r1_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.015672726">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="38" seq="1" ref="0" bb="32" group="33" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="j1qPeCMD1kC_VnT7QNJeSQ" name="Thickness_p3" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.08637087" displayUnit="1/cm">
+                <Parameter id="qFuG7JyjCk-b4p1CY75rtg" name="r2_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0384322177" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="Yg0iQ81c606PTJVQZLzthw" name="L_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.6886041141" displayUnit="cm">
+                <Parameter id="4WnaEIW0tEGenmqhyMM9hw" name="r2_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.008955843">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="34" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="LeQkAvXlO0SYSkQc-mW6hw" name="Intestinal transit rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="3.3333" displayUnit="1/min">
+                <Parameter id="HxX4RWSio0WQvPM1iARxzw" name="Thickness_p1" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0076" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="54" seq="1" ref="0" bb="32" group="46" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
                 </Parameter>
-                <Parameter id="-T0GCUt-tEC9gDjz0LYmGg" name="Fractional steady state fill level" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0060009">
+                <Parameter id="5Qh5LTtM50yo9Y72wYxcRA" name="Thickness_p2" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0394956146" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="58" seq="1" ref="0" bb="32" group="43" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
                 </Parameter>
-                <Parameter id="aJz3HuNdLEGy4o5wp6Gsnw" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="5.7">
+                <Parameter id="YKt_9JbmXUuD__cJBDzuzw" name="Thickness_p3" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.08637087" displayUnit="1/cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
-                  <Info min="0" max="14" flag="122" seq="1" ref="0" bb="32" group="41" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
                 </Parameter>
-                <DistributedParameter id="B_2yklUSQkSSK_6L9M2GJA" name="Effective surface area enhancement factor" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="9bc82IODM0KG1SJZkL-Otw" mode="Logical" isDefault="1">
+                <DistributedParameter id="Sh6n2O2qgEWf0krvtOIJxw" name="Effective surface area enhancement factor" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ywD3jng2_06oxj4vvogPMQ" mode="Logical" isDefault="1">
                   <Children>
-                    <Parameter id="rcZpjCrjMEW9EwjIZiJnDA" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                    <Parameter id="XQ7hCg5-JkKB4bVgWSD-bg" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
                       <Info min="0" flag="18" seq="1" ref="0" bb="32" group="32" />
                     </Parameter>
-                    <Parameter id="IaqO60szLUadnQcCexQAqA" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.5">
+                    <Parameter id="BiqSSz64OE2nD1SKiTWCrw" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.5">
                       <Info min="0" flag="50" seq="1" ref="0" bb="32" group="32" />
                     </Parameter>
                   </Children>
@@ -5847,247 +5888,250 @@
                   </Tags>
                   <Info min="0" flag="122" seq="1" ref="0" bb="32" group="32" />
                 </DistributedParameter>
-                <Container id="-ae_wYI_SkKDucYfLGKCgA" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="PUwqlxUJQka--F0BygEIoQ" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                   <Children>
-                    <Parameter id="_EB4PwzcEkqVFr7ggoMLJA" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" isDefault="1">
-                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                    <Parameter id="b2TE_-C5PEaoU-rZKXbjOQ" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal_GI" isDefault="1">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                     </Parameter>
-                    <Parameter id="MEnANAD1XEe4bcKxAF5jzQ" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" isDefault="1">
-                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                    <Parameter id="0lQVV-ss-U-dGzFqKRde5A" name="Oral mass absorbed segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" rHSFormula="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_coltrans" value="0" displayUnit="µmol">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                    </Parameter>
+                    <Parameter id="EZWszQ91wkKxmFYVtBAwLg" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                     </Parameter>
-                    <Parameter id="ovm3WQsEGkaexOZbLY2D6g" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" isDefault="1">
+                    <Parameter id="_HdMcOBREUumSSDOOpyuSA" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="KzFoOfbwdkinifbhVfLInA" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" isDefault="1">
+                    <Parameter id="Rzto_4f0QkGsF_blNkOwnw" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="ajdEmojIyUu7EmrQXYTgyA" name="Solubility" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_IntestinalSolubility" isDefault="1" displayUnit="mg/l">
-                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="42" />
+                    <Parameter id="Ddoxw34m6kK1j72RkMM16g" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="NvEvhIZJNkqfH_CM1vakLg" name="Solubility table" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.TableFormulaWithXArgument_SolubilityTable" isDefault="1" displayUnit="mg/l">
-                      <Info min="0" flag="50" seq="1" ref="0" bb="2" group="42" />
+                    <Parameter id="UigD8WKva0uYtMk4-0htcg" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="EmtNPrNEyEWF4yzvr-OH8Q" name="Solubility_pKa_pH_Factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" isDefault="1">
-                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="18" />
+                    <Parameter id="B56lCRYbDkmAuR6D0qnlww" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="xzVZdPr_s0ypXg30vyrhZw" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
-                      <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                    <Parameter id="Td73XB3DKkG_v1-BTbBMew" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="hx02awwQhECrxFhZOpTrVw" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" isDefault="1">
+                    <Parameter id="npixeipE10GAOM5VcRS1Cg" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="qJf8jSutrUm64vYzBYiXCg" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" isDefault="1">
+                    <Parameter id="J5Vhseua7U-SmxAoHwIQxQ" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="j7aGfjYnH0CfzPA1IrvP0Q" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" isDefault="1">
+                    <Parameter id="4_UTZEdgbUuVZyeVvf-QSg" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="i2vLc1hFeEW8Yu5cgfNs0w" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal_GI" isDefault="1">
-                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                    <Parameter id="PFhYsKfKkkWAwOQCvgkHhw" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="iG1ZqeudEU6U8h0UzaBmNQ" name="Oral mass absorbed segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" rHSFormula="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_coltrans" value="0" displayUnit="µmol">
-                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                    <Parameter id="a7Ae5AyN5kCUxphD4NwMgQ" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="YpwKTz-4TEayjWtAv-PP-A" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
-                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                    <Parameter id="dTTH2yH86UqURBk9cgKVgQ" name="Solubility" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_IntestinalSolubility" isDefault="1" displayUnit="mg/l">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="42" />
                     </Parameter>
-                    <Parameter id="JUx8XqJgj0-7JVTQWJm_6A" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" isDefault="1">
-                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                    <Parameter id="l_OU-_XrekuHpLi8CGWTQA" name="Solubility table" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.TableFormulaWithXArgument_SolubilityTable" isDefault="1" displayUnit="mg/l">
+                      <Info min="0" flag="50" seq="1" ref="0" bb="2" group="42" />
                     </Parameter>
-                    <Parameter id="ixOIlFHiCk2G8-kv9wPRkA" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" isDefault="1">
-                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                    <Parameter id="Cabw7R9c80q29wlNb3Y8Mg" name="Solubility_pKa_pH_Factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" isDefault="1">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="tm3YjpVATEyYMNG6ck9Z8g" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" isDefault="1">
-                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                    <Parameter id="O35kqnT6LESdqqY3RE3Psw" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                      <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                     </Parameter>
-                    <Parameter id="WDWOaY70fkW3nLwaro27Vw" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" isDefault="1">
-                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                    <Parameter id="sr5TfD6B4Ei7SIu3O9yPwQ" name="Effective concentration in lumen" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_EffectiveLumenConcentration" isDefault="1" displayUnit="µmol/l">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="42" />
                     </Parameter>
                   </Children>
                 </Container>
               </Children>
             </Container>
-            <Container id="YZUlLOUbckymPftQV_qzhg" name="ColonDescendens" mode="Physical" containerType="Compartment">
+            <Container id="swnURfirP0a_IppunMKLQA" name="ColonDescendens" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="Lumen" />
                 <Tag value="LumenSegment" />
               </Tags>
               <Children>
-                <Parameter id="rIqYPW1pxkukB3HZ3bRbiA" name="Effective surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_EffectiveSurfaceArea" isDefault="1" displayUnit="cm²">
+                <Parameter id="A5_JSYfhwkuanft4ZosMvQ" name="Absorption of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Outflow_ColonDescendens" isDefault="1" displayUnit="1/min">
+                  <Info flag="54" seq="1" ref="0" bb="2" group="63" />
+                </Parameter>
+                <Parameter id="kFJe8-egVkqbb_WJRif2IQ" name="Distal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R2" isDefault="1" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
-                  <Info min="0" flag="52" seq="1" ref="0" bb="32" group="33" />
-                </Parameter>
-                <Parameter id="pqZh2-vHekGa_4At5XGRyA" name="Absorption of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Outflow_ColonDescendens" isDefault="1" displayUnit="1/min">
-                  <Info flag="54" seq="1" ref="0" bb="2" group="63" />
+                  <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="8ygrL0UeNUyjxkAgaD47SA" name="Thickness of gut wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Thickness" isDefault="1" displayUnit="cm">
+                <Parameter id="LJlXzoinLEWmX_fz0M-pjQ" name="Effective surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_EffectiveSurfaceArea" isDefault="1" displayUnit="cm²">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="38" seq="1" ref="0" bb="32" group="45" />
+                  <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
+                  <Info min="0" flag="52" seq="1" ref="0" bb="32" group="33" />
                 </Parameter>
-                <Parameter id="pjIHAeRkb0Kkd7VyDL2d6g" name="FillLevelFlag" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevelFlagFlag" isDefault="1">
+                <Parameter id="EsPtMiObwUCKaHgpS_yUtg" name="FillLevelFlag" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevelFlagFlag" isDefault="1">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="gp8A1H5fhkKO7pF0XWJkPQ" name="Fraction of geometric volume filled with liquid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevel" isDefault="1">
+                <Parameter id="wuOPvsfqeUCeG88PqPu0_Q" name="Fraction of geometric volume filled with liquid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevel" isDefault="1">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="v7vUQH7WIUy0yGOgqJI-qQ" name="Geometric surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Area" isDefault="1" displayUnit="cm²">
+                <Parameter id="zuMna-YybUSGoCbHV643ZA" name="Geometric surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Area" isDefault="1" displayUnit="cm²">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info min="0" flag="62" seq="1" ref="0" bb="32" group="33" />
                 </Parameter>
-                <Parameter id="YUbmew0nZE2J6gXeNNPPMg" name="Intestinal transit rate (absolute)" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_InverseLITT_Factor_ColonDescendens" isDefault="1" displayUnit="1/min">
+                <Parameter id="ByPX53LxokivK70qm9Q3PQ" name="Intestinal transit rate (absolute)" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_InverseLITT_Factor_ColonDescendens" isDefault="1" displayUnit="1/min">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="zHr_6GM8Z06NTARfN91jJg" name="Length" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Length" isDefault="1" displayUnit="cm">
+                <Parameter id="b9e_OG1c9kqfyS37QRJe8w" name="Length" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Length" isDefault="1" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info min="0" flag="106" seq="1" ref="0" bb="32" group="34" />
                 </Parameter>
-                <Parameter id="q2GcS_9OjEOVmSYVftSK8g" name="Liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Liquid_StartValue" isDefault="1" rHSFormula="Lumen_PKSim.LiquidRHS_coldesc" displayUnit="l">
+                <Parameter id="jdFj88QsdkaiyILEPucfjA" name="Liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Liquid_StartValue" isDefault="1" rHSFormula="Lumen_PKSim.LiquidRHS_coldesc" displayUnit="l">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="j-c7Wgegw0mnqIqBbJ26qg" name="Liquid transfer rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_LiquidTransferRate_coldesc" isDefault="1" displayUnit="l/min">
+                <Parameter id="hdVXokQFVUyAP8nkv5zlWw" name="Liquid transfer rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_LiquidTransferRate_coldesc" isDefault="1" displayUnit="l/min">
                   <Info flag="52" seq="1" ref="0" bb="2" group="39" />
                 </Parameter>
-                <Parameter id="HrnpaGM220qAQIzwMFgxRg" name="Secretion of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Inflow_ColonDescendens" isDefault="1" displayUnit="l/min">
-                  <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
-                </Parameter>
-                <Parameter id="u3-4cmKftkW2qq5eD0m4wA" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_LumenSegment" isDefault="1" displayUnit="l">
-                  <Info min="0" flag="62" seq="1" ref="0" bb="2" group="56" />
-                </Parameter>
-                <Parameter id="_zN419-_qEi67E_Mz380kQ" name="Volume (gut wall)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="MucosaVolume_Human.PARAM_VolumeGutWall_ColonDescendens" isDefault="1" displayUnit="l">
+                <Parameter id="_9o1gjFqAkCMECDGyxZf6g" name="Proximal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R1" isDefault="1" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="62" seq="1" ref="0" bb="32" group="44" />
+                  <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="7u2XslOGm0uNBL7j0OjGKg" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
-                  <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                <Parameter id="cAUsRMJSsEe_i1nO5qMtqA" name="Secretion of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Inflow_ColonDescendens" isDefault="1" displayUnit="l/min">
+                  <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="QHEP5TnDf0yVizFuFA1KHA" name="Distal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R2" isDefault="1" displayUnit="cm">
+                <Parameter id="-QTJelE5CU6FEzmcPU1FMg" name="Thickness of gut wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Thickness" isDefault="1" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
+                  <Info min="0" flag="38" seq="1" ref="0" bb="32" group="45" />
+                </Parameter>
+                <Parameter id="OKvmYEHB4EunIigT7lg1Yw" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_LumenSegment" isDefault="1" displayUnit="l">
+                  <Info min="0" flag="62" seq="1" ref="0" bb="2" group="56" />
                 </Parameter>
-                <Parameter id="gNmZY_5FtUyMjnInHJ8tcA" name="Proximal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R1" isDefault="1" displayUnit="cm">
+                <Parameter id="cNk_RMgQy0ahsdzcgF4JdA" name="Volume (gut wall)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="MucosaVolume_Human.PARAM_VolumeGutWall_ColonDescendens" isDefault="1" displayUnit="l">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
+                  <Info min="0" flag="62" seq="1" ref="0" bb="32" group="44" />
+                </Parameter>
+                <Parameter id="zQEXV_AmgUOw-rcAjMtv9A" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                  <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                 </Parameter>
-                <Parameter id="EV2T923esEmIBdOadSRzdA" name="r1_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0384322177" displayUnit="cm">
+                <Parameter id="AEi8ohqJfE6sZ3RvkZXukQ" name="Fractional steady state fill level" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0060009">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                  <Info min="0" flag="58" seq="1" ref="0" bb="32" group="43" />
                 </Parameter>
-                <Parameter id="x7o5Ou7ptk6-N5WjNsFvRw" name="Thickness_p3" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.08977747" displayUnit="1/cm">
+                <Parameter id="UyKUaCbmJkGDKtiBso2m2A" name="Intestinal transit rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="5" displayUnit="1/min">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                  <Info min="0" flag="54" seq="1" ref="0" bb="32" group="46" />
                 </Parameter>
-                <Parameter id="XGC9fIt56UuXTqKj9DebMQ" name="Thickness_p2" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0601543776" displayUnit="cm">
+                <Parameter id="rKca0JHukUygXKnGVbgBPQ" name="L_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.4227543951" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="34" />
                 </Parameter>
-                <Parameter id="alEqwNy4J06CHQHZQHbAQg" name="Thickness_p1" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0118" displayUnit="cm">
+                <Parameter id="4HobE2WHvk-GrrTNx8yFQQ" name="L_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.098514277">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="34" />
                 </Parameter>
-                <Parameter id="kqbljkYDqEO1eWSZC3T_7w" name="r2_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.008955843">
+                <Parameter id="xVyw41-phEm1Wa7k-NZnUA" name="Microvilli factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                  <Info min="0" flag="38" seq="1" ref="0" bb="32" group="33" />
                 </Parameter>
-                <Parameter id="2_OH1XLxh0CTDLJ81ksJqg" name="r1_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.008955843">
+                <Parameter id="j26g_CYZakKnJwEtVnf4sg" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="6.6">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                  <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
+                  <Info min="0" max="14" flag="122" seq="1" ref="0" bb="32" group="41" />
                 </Parameter>
-                <Parameter id="UWB2-op3-E-oi_grufxafg" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="6.6">
+                <Parameter id="RFdNUgBXdEyB2bbKeLRLpQ" name="r1_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0384322177" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
-                  <Info min="0" max="14" flag="122" seq="1" ref="0" bb="32" group="41" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="3whWE7-q80qcAeBWaUT4ag" name="Microvilli factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                <Parameter id="4ZVH12e_iEihaN1g2SgJ9g" name="r1_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.008955843">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="38" seq="1" ref="0" bb="32" group="33" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="UXwZ6XldRUmkZanfUC_gPg" name="L_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.098514277">
+                <Parameter id="qz7r1NLtV0a4T6yLpiwa0A" name="r2_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0384322177" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="34" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="fgglxb7nb0SCrWx-RMzExg" name="L_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.4227543951" displayUnit="cm">
+                <Parameter id="nb7qKfQsD0OJIULbNqiE-w" name="r2_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.008955843">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="34" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="WSu0WKDcxUqPIf7BHMO6Pw" name="Intestinal transit rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="5" displayUnit="1/min">
+                <Parameter id="X_T00ILotUCIunwxzTzwAw" name="Thickness_p1" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0118" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="54" seq="1" ref="0" bb="32" group="46" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
                 </Parameter>
-                <Parameter id="zAx6i7OSi0WczKs0kAjIKA" name="Fractional steady state fill level" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0060009">
+                <Parameter id="ZufDXN2IG0aJAto_97u2gQ" name="Thickness_p2" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0601543776" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="58" seq="1" ref="0" bb="32" group="43" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
                 </Parameter>
-                <Parameter id="BVA7N59BdkmaJfO8pquX2Q" name="r2_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0384322177" displayUnit="cm">
+                <Parameter id="wOZTwy4leEel10d1uP6lVQ" name="Thickness_p3" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.08977747" displayUnit="1/cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
                 </Parameter>
-                <DistributedParameter id="LtMPIKpi-0-dJ1JHqbR-uQ" name="Effective surface area enhancement factor" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="uPcXW8WmXUK9UOVyWQNgCA" mode="Logical" isDefault="1">
+                <DistributedParameter id="a5Bw4QeHz0erdGM-NRuM2w" name="Effective surface area enhancement factor" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="k_FdoVQ7H0u2tYwvwU4Pag" mode="Logical" isDefault="1">
                   <Children>
-                    <Parameter id="-oFwfQQg60uQeNqfFWTW8Q" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                    <Parameter id="XEDDlomJAESA1ukdFDvJkg" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
                       <Info min="0" flag="18" seq="1" ref="0" bb="32" group="32" />
                     </Parameter>
-                    <Parameter id="Z6oL78Q0Ckytdg1ADqdCJw" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.5">
+                    <Parameter id="wIF7vySHe0SESraDpEZLxA" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.5">
                       <Info min="0" flag="50" seq="1" ref="0" bb="32" group="32" />
                     </Parameter>
                   </Children>
@@ -6097,247 +6141,250 @@
                   </Tags>
                   <Info min="0" flag="122" seq="1" ref="0" bb="32" group="32" />
                 </DistributedParameter>
-                <Container id="OlT7_nCjskqODtfg3HMuFw" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="PrS9VIxQD0OBVrkn8q88yQ" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                   <Children>
-                    <Parameter id="JrzryZ5_xkq9ynXD439TRw" name="Solubility_pKa_pH_Factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" isDefault="1">
-                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="18" />
-                    </Parameter>
-                    <Parameter id="UeFp1wwv9Emia0uSaF-LcA" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" isDefault="1">
-                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
-                    </Parameter>
-                    <Parameter id="uFUEnNWs1EytHIO2jSAaJQ" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal_GI" isDefault="1">
+                    <Parameter id="4tf4wqjnYEmIaAnkJ96rMQ" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal_GI" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                     </Parameter>
-                    <Parameter id="keRUYjWJqEKEtzl92Pe56w" name="Oral mass absorbed segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" rHSFormula="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_coldesc" value="0" displayUnit="µmol">
+                    <Parameter id="2q5efzGalkeOxkV5PcpQxQ" name="Oral mass absorbed segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" rHSFormula="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_coldesc" value="0" displayUnit="µmol">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                     </Parameter>
-                    <Parameter id="aO2FAF92oU-gyo4qjHU0Hg" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                    <Parameter id="CZKvOuYlSUaEFvvghybnjQ" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                     </Parameter>
-                    <Parameter id="mL-2NvTCe0uYMBOjAQxa-g" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" isDefault="1">
+                    <Parameter id="EPW84-z69UytaBlF3nj62w" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="bKN7-3iV60mxoY4SDfH-KA" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" isDefault="1">
+                    <Parameter id="1nYIJLl7t0eBMYVWVaC_Pg" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="RL0mjkeuwUy2hOzp-1b9gg" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" isDefault="1">
+                    <Parameter id="SdUupb34OE64S4Umlj-5lA" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="lukKiNpyHkaLAhu4fKV51A" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" isDefault="1">
+                    <Parameter id="OnZU6L0hb0uTX5TZm5lrng" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="e56EVrVPdkqQu3Edl9t4NQ" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" isDefault="1">
+                    <Parameter id="FQprtj60qU6DyDh1syso8A" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="k1552_RphEermoOqhaJcUA" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" isDefault="1">
+                    <Parameter id="NmcxHPwjf0Wm7E1TrwG5DQ" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="SrdALgbo_0KaTHEZuAA-ew" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" isDefault="1">
+                    <Parameter id="rjHQ_Nmz-0Wuiv0I0XU1sg" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="S3h8xu9Ac0qGxdLjyxl4fg" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" isDefault="1">
+                    <Parameter id="vh4sjJaY30uIwdxByppTYQ" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="kEQSmSZpMkuH402zD6krlg" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" isDefault="1">
+                    <Parameter id="ScosAlP3Q0uZgatgEPWpRQ" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="NUH_zAM9kUOvIneuhIa-Jg" name="Solubility" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_IntestinalSolubility" isDefault="1" displayUnit="mg/l">
+                    <Parameter id="Pe_DPWPL2EifgGJLg2B98A" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                    </Parameter>
+                    <Parameter id="R8mh1t4UnkyDQtagmIiHqQ" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                    </Parameter>
+                    <Parameter id="w3bJKpF7tU2n1TZuOra2Ww" name="Solubility" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_IntestinalSolubility" isDefault="1" displayUnit="mg/l">
                       <Info min="0" flag="122" seq="1" ref="0" bb="2" group="42" />
                     </Parameter>
-                    <Parameter id="7zW6OZBzV02G-Kvd_ZnxpQ" name="Solubility table" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.TableFormulaWithXArgument_SolubilityTable" isDefault="1" displayUnit="mg/l">
+                    <Parameter id="0dLFpGCyhEeCu3pT-lupRA" name="Solubility table" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.TableFormulaWithXArgument_SolubilityTable" isDefault="1" displayUnit="mg/l">
                       <Info min="0" flag="50" seq="1" ref="0" bb="2" group="42" />
                     </Parameter>
-                    <Parameter id="ogUcTm4Z40ygNGEA_0LavA" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" isDefault="1">
-                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                    <Parameter id="kiR-S-sj2EmylkT-Tk5vjg" name="Solubility_pKa_pH_Factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" isDefault="1">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="0I2_30P93EeG6pNSzg6dDQ" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                    <Parameter id="9s65mBILdkub4Ht0j-RKWA" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
                       <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                     </Parameter>
+                    <Parameter id="q_kY1mhaxUeYsd2Mt21SCA" name="Effective concentration in lumen" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_EffectiveLumenConcentration" isDefault="1" displayUnit="µmol/l">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="42" />
+                    </Parameter>
                   </Children>
                 </Container>
               </Children>
             </Container>
-            <Container id="B12kRDWtqUGL5miHA0Saxg" name="ColonSigmoid" mode="Physical" containerType="Compartment">
+            <Container id="8EVK1diXzEKNlC-Y6QOZJg" name="ColonSigmoid" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="Lumen" />
                 <Tag value="LumenSegment" />
               </Tags>
               <Children>
-                <Parameter id="48h6fpYwpEGJQsTGNbW-PQ" name="Geometric surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Area" isDefault="1" displayUnit="cm²">
-                  <Tags>
+                <Parameter id="vpFXSfwl_0qmJPRQwPpNnw" name="Absorption of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Outflow_ColonSigmoid" isDefault="1" displayUnit="1/min">
+                  <Info flag="54" seq="1" ref="0" bb="2" group="63" />
+                </Parameter>
+                <Parameter id="q7ZsXjTBPEqxP9051RVL7g" name="Distal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R2" isDefault="1" displayUnit="cm">
+                  <Tags>
+                    <Tag value="Lumen" />
+                    <Tag value="LumenSegment" />
+                  </Tags>
+                  <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
+                </Parameter>
+                <Parameter id="SEY11_0l2EyjayO6gnmKHA" name="Effective surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_EffectiveSurfaceArea" isDefault="1" displayUnit="cm²">
+                  <Tags>
+                    <Tag value="Lumen" />
+                    <Tag value="LumenSegment" />
+                  </Tags>
+                  <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
+                  <Info min="0" flag="52" seq="1" ref="0" bb="32" group="33" />
+                </Parameter>
+                <Parameter id="oJmum1OND0mIIiWHuIep2A" name="FillLevelFlag" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevelFlagFlag" isDefault="1">
+                  <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                </Parameter>
+                <Parameter id="8Ea6GvasxE-sJo6amvEdOg" name="Fraction of geometric volume filled with liquid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevel" isDefault="1">
+                  <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                </Parameter>
+                <Parameter id="4gp5SkaRCEWv6S6mtvkiCw" name="Geometric surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Area" isDefault="1" displayUnit="cm²">
+                  <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info min="0" flag="62" seq="1" ref="0" bb="32" group="33" />
                 </Parameter>
-                <Parameter id="445sW-3eTEmPYXE81iyZxg" name="Intestinal transit rate (absolute)" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_InverseLITT_Factor_ColonSigmoid" isDefault="1" displayUnit="1/min">
+                <Parameter id="dNEflzqwh0yeErLIBPRK5A" name="Intestinal transit rate (absolute)" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_InverseLITT_Factor_ColonSigmoid" isDefault="1" displayUnit="1/min">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="W8yNvAsUCU-tTMilwAG2Ew" name="Length" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Length" isDefault="1" displayUnit="cm">
+                <Parameter id="eH-Xs8dUM0KxEVM5gbbGuQ" name="Length" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Length" isDefault="1" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info min="0" flag="106" seq="1" ref="0" bb="32" group="34" />
                 </Parameter>
-                <Parameter id="KGn1D6MTS061wp_9J2VDbQ" name="Liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Liquid_StartValue" isDefault="1" rHSFormula="Lumen_PKSim.LiquidRHS_colsigm" displayUnit="l">
+                <Parameter id="TNSt6apVnE2RNNr-3UUVkA" name="Liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Liquid_StartValue" isDefault="1" rHSFormula="Lumen_PKSim.LiquidRHS_colsigm" displayUnit="l">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="MiQkqmy4sEewiUABBhgkVA" name="Liquid transfer rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_LiquidTransferRate_colsigm" isDefault="1" displayUnit="l/min">
+                <Parameter id="dvAI4weGTEuXev8orbtu4w" name="Liquid transfer rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_LiquidTransferRate_colsigm" isDefault="1" displayUnit="l/min">
                   <Info flag="52" seq="1" ref="0" bb="2" group="39" />
                 </Parameter>
-                <Parameter id="OR32jtnr-UmOeZhs-YrvXA" name="Proximal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R1" isDefault="1" displayUnit="cm">
+                <Parameter id="4NfaGiePZkGLgf9AtVo4ig" name="Proximal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R1" isDefault="1" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="rAQFgOoVKUSQ42ShnRO8VA" name="Secretion of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Inflow_ColonSigmoid" isDefault="1" displayUnit="l/min">
+                <Parameter id="mAmAxy4pKUCzinSMGpkjag" name="Secretion of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Inflow_ColonSigmoid" isDefault="1" displayUnit="l/min">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="lAV9U5_wmUmIQwoh9Ad3hg" name="Thickness of gut wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Thickness" isDefault="1" displayUnit="cm">
+                <Parameter id="M1TEVA2_UUSLAUHSOt2KZQ" name="Thickness of gut wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Thickness" isDefault="1" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info min="0" flag="38" seq="1" ref="0" bb="32" group="45" />
                 </Parameter>
-                <Parameter id="rFKEqIysG0eZI2HL4zsYmQ" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_LumenSegment" isDefault="1" displayUnit="l">
+                <Parameter id="8Jodrg2QcU-iEqObkAk3uw" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_LumenSegment" isDefault="1" displayUnit="l">
                   <Info min="0" flag="62" seq="1" ref="0" bb="2" group="56" />
                 </Parameter>
-                <Parameter id="ZIddFJ5D0EyFbC6B7ldQZA" name="Effective surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_EffectiveSurfaceArea" isDefault="1" displayUnit="cm²">
-                  <Tags>
-                    <Tag value="Lumen" />
-                    <Tag value="LumenSegment" />
-                  </Tags>
-                  <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
-                  <Info min="0" flag="52" seq="1" ref="0" bb="32" group="33" />
-                </Parameter>
-                <Parameter id="Ekfd8kypLEee5Wy2zGVLKw" name="Volume (gut wall)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="MucosaVolume_Human.PARAM_VolumeGutWall_ColonSigmoid" isDefault="1" displayUnit="l">
+                <Parameter id="eQ3gv3tMs0iaG3Mzptzwnw" name="Volume (gut wall)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="MucosaVolume_Human.PARAM_VolumeGutWall_ColonSigmoid" isDefault="1" displayUnit="l">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info min="0" flag="62" seq="1" ref="0" bb="32" group="44" />
                 </Parameter>
-                <Parameter id="1ifE_v8dwE2u6YCC6GE-Tw" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                <Parameter id="rjD-LBc0vUCmzvhO9-N7yw" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
                   <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                 </Parameter>
-                <Parameter id="8twFS51yxE2WTMTfEl_Fmg" name="Fraction of geometric volume filled with liquid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevel" isDefault="1">
-                  <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
-                </Parameter>
-                <Parameter id="Ve1gnCs-bEiRkM6pRImiIg" name="FillLevelFlag" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevelFlagFlag" isDefault="1">
-                  <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
-                </Parameter>
-                <Parameter id="A5hhVxm9_kSoF4o4xq8afg" name="Absorption of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Outflow_ColonSigmoid" isDefault="1" displayUnit="1/min">
-                  <Info flag="54" seq="1" ref="0" bb="2" group="63" />
-                </Parameter>
-                <Parameter id="CifWUwhoSkmcnhL_JHxbwQ" name="Distal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R2" isDefault="1" displayUnit="cm">
+                <Parameter id="PDg56PfFFUiuksKtZ7rhPA" name="Fractional steady state fill level" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0060009">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
+                  <Info min="0" flag="58" seq="1" ref="0" bb="32" group="43" />
                 </Parameter>
-                <Parameter id="1lvLIUX2yU-9fcswGOgcYA" name="L_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5337898629" displayUnit="cm">
+                <Parameter id="mqi4P3vbnkuPKayvmtRmyA" name="Intestinal transit rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="4.0741" displayUnit="1/min">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="34" />
+                  <Info min="0" flag="54" seq="1" ref="0" bb="32" group="46" />
                 </Parameter>
-                <Parameter id="7U0GsEdzKEadbEjXhfwrAA" name="r2_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0384322177" displayUnit="cm">
+                <Parameter id="syEGYyv0WUW4VucpSyu61Q" name="L_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5337898629" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="34" />
                 </Parameter>
-                <Parameter id="E1-JSMzNUk6gP9nNv3bzrA" name="Thickness_p3" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0889014" displayUnit="1/cm">
+                <Parameter id="gAR6NCxG_UaCK1wIRp-YWg" name="L_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.121300709">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="34" />
                 </Parameter>
-                <Parameter id="DENEfsPxy0u57SS5yOvaQw" name="Thickness_p2" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0274432593" displayUnit="cm">
+                <Parameter id="T2G7xBUd602_PvmFOP32ow" name="Microvilli factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                  <Info min="0" flag="38" seq="1" ref="0" bb="32" group="33" />
                 </Parameter>
-                <Parameter id="xwturkxydkuSQgx8ODtMcQ" name="Fractional steady state fill level" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0060009">
+                <Parameter id="3Q75_p8ZG0u499uK3dWZfA" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="6.6">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="58" seq="1" ref="0" bb="32" group="43" />
+                  <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
+                  <Info min="0" max="14" flag="122" seq="1" ref="0" bb="32" group="41" />
                 </Parameter>
-                <Parameter id="0_mMPIclHEW2EwOX2TkJZg" name="r2_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.008955843">
+                <Parameter id="mHUj6GdgQEi3-J_ExWQCXQ" name="r1_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0384322177" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="w04aRoVfc02bODVHTY1aNA" name="Intestinal transit rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="4.0741" displayUnit="1/min">
-                  <Tags>
-                    <Tag value="Lumen" />
-                    <Tag value="LumenSegment" />
-                  </Tags>
-                  <Info min="0" flag="54" seq="1" ref="0" bb="32" group="46" />
-                </Parameter>
-                <Parameter id="3QGPTc1kRUaYr5WSHGYqTQ" name="r1_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.008955843">
+                <Parameter id="d8KcpBBdP0CM9jdpwvSAaQ" name="r1_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.008955843">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="576hrFIC3kCzS3LCA20iGw" name="r1_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0384322177" displayUnit="cm">
+                <Parameter id="uFt3Kd0PRkygWGxO3loMzg" name="r2_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0384322177" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="T6iSt62S3kup56tCWOn5Ug" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="6.6">
+                <Parameter id="mu8zHUtzX0yzn9Ruatze9w" name="r2_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.008955843">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
-                  <Info min="0" max="14" flag="122" seq="1" ref="0" bb="32" group="41" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="mrdFyXoXrEiLUt3Xh6kRIA" name="Microvilli factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                <Parameter id="Aku2z7Mkw0S9Q-L0YTu0bA" name="Thickness_p1" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.00536" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="38" seq="1" ref="0" bb="32" group="33" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
                 </Parameter>
-                <Parameter id="C0tCsdgKU02tIjicEG9rLQ" name="L_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.121300709">
+                <Parameter id="fygEtGQkVEKxKXNUar0_OQ" name="Thickness_p2" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0274432593" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="34" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
                 </Parameter>
-                <Parameter id="hDqSMJghJUq8-NyJPDMk7Q" name="Thickness_p1" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.00536" displayUnit="cm">
+                <Parameter id="jjvd47z5KEKrEVVfDhvP3g" name="Thickness_p3" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0889014" displayUnit="1/cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info flag="54" seq="1" ref="0" bb="32" group="45" />
                 </Parameter>
-                <DistributedParameter id="GkDH8DkFr02hY4Vw-Pt3xw" name="Effective surface area enhancement factor" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="tXRy1zHZDkm8uAQTV4tFNw" mode="Logical" isDefault="1">
+                <DistributedParameter id="2ZEC45--8Ue7KI8nOhnbLw" name="Effective surface area enhancement factor" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="YrrL57f_N0i1SkBLxSGPCA" mode="Logical" isDefault="1">
                   <Children>
-                    <Parameter id="6xTVsV91Z0abz0o3AAjxAw" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                    <Parameter id="la9D99sWokK7DHHdl48HLQ" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
                       <Info min="0" flag="18" seq="1" ref="0" bb="32" group="32" />
                     </Parameter>
-                    <Parameter id="nireKoyO4UuJscNNmE-iDQ" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.5">
+                    <Parameter id="fKfijzqVJkuB7IYS23ciCA" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.5">
                       <Info min="0" flag="50" seq="1" ref="0" bb="32" group="32" />
                     </Parameter>
                   </Children>
@@ -6347,83 +6394,86 @@
                   </Tags>
                   <Info min="0" flag="122" seq="1" ref="0" bb="32" group="32" />
                 </DistributedParameter>
-                <Container id="1CzGKe5jjE-i5J8jU3k7Ww" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="ZwOUJ-e9Z0-gjkftHj6SFA" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                   <Children>
-                    <Parameter id="aNeEiREx6kyxFmWRrXI1gA" name="Solubility" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_IntestinalSolubility" isDefault="1" displayUnit="mg/l">
-                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="42" />
+                    <Parameter id="VuHMZRnTTkekhn81fzZF4Q" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal_GI" isDefault="1">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                     </Parameter>
-                    <Parameter id="gGu-6xhIOE2oUEdbdy-3hA" name="Oral mass absorbed segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" rHSFormula="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_colsigm" value="0" displayUnit="µmol">
+                    <Parameter id="-e_SdCBCYEGTFguUkyxvDQ" name="Oral mass absorbed segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" rHSFormula="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_colsigm" value="0" displayUnit="µmol">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                     </Parameter>
-                    <Parameter id="K-sBM4eIMEOA-6cRxVANBQ" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                    <Parameter id="CtirQDqJi06sKwam0eW2ug" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                     </Parameter>
-                    <Parameter id="knQnAm_eTkO6u0BB7FMzXg" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" isDefault="1">
+                    <Parameter id="Xa5S-b-UCUePfB-5LpvzLQ" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                    </Parameter>
+                    <Parameter id="3ZnS-DrfJEiDiYF8NmspEA" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="PdTkR1CA20eNDHfL3iHc5Q" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" isDefault="1">
+                    <Parameter id="PE2o3BL6LkWPqCeiRTLBVw" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="LwvNc-yei0W46Bx6SKo8TQ" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" isDefault="1">
+                    <Parameter id="2in-riWQ1U6WUue7HPbyDQ" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="-g1Hrk3aRky0jlIwSPf8dQ" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" isDefault="1">
+                    <Parameter id="s64_ANFcmUy9Is9SouGaCQ" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="bumaX6mD_EycY-8m8V1zwQ" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" isDefault="1">
+                    <Parameter id="hYE1UUQxIEWV8xhnrOK-4A" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="fSpZbf3BnUqLQ1G9pt4X3w" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" isDefault="1">
+                    <Parameter id="TaDLeE4MUEmRu5ZUcFOwrQ" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="OM9nLEzcm0yc8xVa6gD4Rw" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" isDefault="1">
+                    <Parameter id="zMTzkuUEHkmDuCptq7R20A" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="FmG3n53Cmk6BLlHCOTxNaA" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" isDefault="1">
+                    <Parameter id="EC13YnyK3UyOOCZAVueDIw" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="npCpjK-PG0qS_alJkIeVUQ" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" isDefault="1">
+                    <Parameter id="d-1807H1uka72dALdJGlQg" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="x8MG93d3AUil3fSRGgI_2g" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" isDefault="1">
+                    <Parameter id="Uw7HncXQtky9hOiT2cOaxQ" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="Fh0uKc85P0yWTviGY_odgw" name="Solubility table" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.TableFormulaWithXArgument_SolubilityTable" isDefault="1" displayUnit="mg/l">
+                    <Parameter id="oAU37kgl50y2Ei8SMWcJtg" name="Solubility" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_IntestinalSolubility" isDefault="1" displayUnit="mg/l">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="42" />
+                    </Parameter>
+                    <Parameter id="Y43SD8t30ESgtPCaJ9WvSA" name="Solubility table" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.TableFormulaWithXArgument_SolubilityTable" isDefault="1" displayUnit="mg/l">
                       <Info min="0" flag="50" seq="1" ref="0" bb="2" group="42" />
                     </Parameter>
-                    <Parameter id="EZU-zpLp3EWt4j7H9s-vpw" name="Solubility_pKa_pH_Factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" isDefault="1">
+                    <Parameter id="WbzwnAgx-0asuFp36tfIzg" name="Solubility_pKa_pH_Factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="-vo1CaoFlESlW50CHYDi9w" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                    <Parameter id="kXy7S9LXdEacZ9digF_KvA" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
                       <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                     </Parameter>
-                    <Parameter id="gWc5XjUJdk-j2QdLYmRpfQ" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" isDefault="1">
-                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
-                    </Parameter>
-                    <Parameter id="MBqz8VwMUk2lCCeReHK_VQ" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal_GI" isDefault="1">
-                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                    <Parameter id="NZlYi44IJESAF0PyGF_aLw" name="Effective concentration in lumen" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_EffectiveLumenConcentration" isDefault="1" displayUnit="µmol/l">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="42" />
                     </Parameter>
                   </Children>
                 </Container>
               </Children>
             </Container>
-            <Container id="N4-kBR_40ku5rWhp0VEzqA" name="Rectum" mode="Physical" containerType="Compartment">
+            <Container id="94Sc5RUGNUaXs_bDJ2T7lQ" name="Rectum" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="Lumen" />
                 <Tag value="LumenSegment" />
               </Tags>
               <Children>
-                <Parameter id="1O0k_6GV90CU9eh2BJUqzw" name="Absorption of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Outflow_Rectum" isDefault="1" displayUnit="1/min">
+                <Parameter id="GmyjwmBmeUOsCr13V9AxIw" name="Absorption of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Outflow_Rectum" isDefault="1" displayUnit="1/min">
                   <Info flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="aunTGTGcZ0K4PALP8MX5Rg" name="Distal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R2" isDefault="1" displayUnit="cm">
+                <Parameter id="nKeqWfAQmEqsd5CtJILDYw" name="Distal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R2" isDefault="1" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="vk38SNQTwU-CVhqbzsSb2Q" name="Effective surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_EffectiveSurfaceArea" isDefault="1" displayUnit="cm²">
+                <Parameter id="kq2tiDeH6kixaJEeNrCDwA" name="Effective surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_EffectiveSurfaceArea" isDefault="1" displayUnit="cm²">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
@@ -6431,163 +6481,163 @@
                   <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
                   <Info min="0" flag="52" seq="1" ref="0" bb="32" group="33" />
                 </Parameter>
-                <Parameter id="5nL-zzwDkEaTpcSvIKhtZA" name="FillLevelFlag" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevelFlagFlag" isDefault="1">
+                <Parameter id="E_47lqYiwEaLkCVIuv2aIw" name="FillLevelFlag" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevelFlagFlag" isDefault="1">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="QhEhNlrl7UKTQaTaSsJOMg" name="Fraction of geometric volume filled with liquid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevel" isDefault="1">
+                <Parameter id="OMTOO_4G5EyXve_HtWr4CQ" name="Fraction of geometric volume filled with liquid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevel" isDefault="1">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="PJa6K_DWjU-XM03DtQ72gw" name="Length" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Length" isDefault="1" displayUnit="cm">
-                  <Tags>
-                    <Tag value="Lumen" />
-                    <Tag value="LumenSegment" />
-                  </Tags>
-                  <Info min="0" flag="106" seq="1" ref="0" bb="32" group="34" />
-                </Parameter>
-                <Parameter id="O1PeL-R8JUmGR4GaB0xEAw" name="Geometric surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Area" isDefault="1" displayUnit="cm²">
+                <Parameter id="9dVbIGqUkk-fmWT7cl22Dw" name="Geometric surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Area" isDefault="1" displayUnit="cm²">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info min="0" flag="62" seq="1" ref="0" bb="32" group="33" />
                 </Parameter>
-                <Parameter id="CPT8lrrF3k-LxJndcWHlCQ" name="Volume (gut wall)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="MucosaVolume_Human.PARAM_VolumeGutWall_Rectum" isDefault="1" displayUnit="l">
+                <Parameter id="Mh0omzpoGEy9py1xiX9i4g" name="Intestinal transit rate (absolute)" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_InverseLITT_Factor_Rectum" isDefault="1" displayUnit="1/min">
+                  <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                </Parameter>
+                <Parameter id="ZibFVANP5ka71ccAIrGBxg" name="Length" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Length" isDefault="1" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="62" seq="1" ref="0" bb="32" group="44" />
+                  <Info min="0" flag="106" seq="1" ref="0" bb="32" group="34" />
                 </Parameter>
-                <Parameter id="OONIac3Mfkmg6S1a9YNG_g" name="Liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Liquid_StartValue" isDefault="1" rHSFormula="Lumen_PKSim.LiquidRHS_rect" displayUnit="l">
+                <Parameter id="PltZeCB5bE2-icHNndLTTw" name="Liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Liquid_StartValue" isDefault="1" rHSFormula="Lumen_PKSim.LiquidRHS_rect" displayUnit="l">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="b09LF8pmYEmnuz_xCMgOZA" name="Liquid transfer rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_LiquidTransferRate_rect" isDefault="1" displayUnit="l/min">
+                <Parameter id="y9G2xa8wN0iw93q3iZbKuQ" name="Liquid transfer rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_LiquidTransferRate_rect" isDefault="1" displayUnit="l/min">
                   <Info flag="52" seq="1" ref="0" bb="2" group="39" />
                 </Parameter>
-                <Parameter id="0IfQsemjg0KpGx11Xm4-pw" name="Proximal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R1" isDefault="1" displayUnit="cm">
+                <Parameter id="_cXAToAXbkCRJN1-6z-AYw" name="Proximal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R1" isDefault="1" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="IVv6-zHI4EewI-UyF6I-1A" name="Secretion of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Inflow_Rectum" isDefault="1" displayUnit="l/min">
+                <Parameter id="8XOtPb6n_k2qrQPi7ss06w" name="Secretion of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Inflow_Rectum" isDefault="1" displayUnit="l/min">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="BtC8gCchhUyDmpm9OMPARA" name="Thickness of gut wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Thickness" isDefault="1" displayUnit="cm">
+                <Parameter id="8UeMJhauk0647iYcA75eKw" name="Thickness of gut wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Thickness" isDefault="1" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info min="0" flag="38" seq="1" ref="0" bb="32" group="45" />
                 </Parameter>
-                <Parameter id="ebFt414HEU-wF6a2DuKeag" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
-                  <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
-                </Parameter>
-                <Parameter id="EEsd07-d1ES-Uue-zHhkpA" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_LumenSegment" isDefault="1" displayUnit="l">
+                <Parameter id="G_rVi8yHk0ucta577APB0Q" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_LumenSegment" isDefault="1" displayUnit="l">
                   <Info min="0" flag="62" seq="1" ref="0" bb="2" group="56" />
                 </Parameter>
-                <Parameter id="J9BqL2VNKEWu3dfmR-kjYw" name="Intestinal transit rate (absolute)" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_InverseLITT_Factor_Rectum" isDefault="1" displayUnit="1/min">
-                  <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
-                </Parameter>
-                <Parameter id="xqRNT781YkC440uIu_knWQ" name="L_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.052420808">
+                <Parameter id="yoUeURHyHke2R2sgEq0gtA" name="Volume (gut wall)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="MucosaVolume_Human.PARAM_VolumeGutWall_Rectum" isDefault="1" displayUnit="l">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="34" />
+                  <Info min="0" flag="62" seq="1" ref="0" bb="32" group="44" />
                 </Parameter>
-                <Parameter id="u0AV7ysCiEusTVTojhcriw" name="Intestinal transit rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="315.618" displayUnit="1/min">
+                <Parameter id="waJDYxMyJ0aZEYyYKCgNKw" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                  <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                </Parameter>
+                <Parameter id="-GLQGCVri0OOtho2qWYKKg" name="Fractional steady state fill level" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0060009">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="54" seq="1" ref="0" bb="32" group="46" />
+                  <Info min="0" flag="58" seq="1" ref="0" bb="32" group="43" />
                 </Parameter>
-                <Parameter id="jb1Z1lRdLUW2Caqkj4DVlQ" name="Fractional steady state fill level" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0060009">
+                <Parameter id="BfXXgOG6CUGyG-2BRwYvpg" name="Intestinal transit rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="315.618" displayUnit="1/min">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="58" seq="1" ref="0" bb="32" group="43" />
+                  <Info min="0" flag="54" seq="1" ref="0" bb="32" group="46" />
                 </Parameter>
-                <Parameter id="kOVa0neoaE6aOs1C8zWFcw" name="Microvilli factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                <Parameter id="riHHL4TPhEKQ8eHd_QaXaQ" name="L_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.1569046761" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="38" seq="1" ref="0" bb="32" group="33" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="34" />
                 </Parameter>
-                <Parameter id="6R3q6L1VIkC8QLedMup92A" name="L_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.1569046761" displayUnit="cm">
+                <Parameter id="f0U6xfpKzkCYoe54THhqtQ" name="L_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.052420808">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info flag="54" seq="1" ref="0" bb="32" group="34" />
                 </Parameter>
-                <Parameter id="zkU3SrXTokKl_45pD4nHng" name="Thickness_p2" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0324721331" displayUnit="cm">
+                <Parameter id="LPuQ3p1j_EuBEtHV-8EF0A" name="Microvilli factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                  <Info min="0" flag="38" seq="1" ref="0" bb="32" group="33" />
                 </Parameter>
-                <Parameter id="27xFnwY7DEy90FF9V0DExA" name="Thickness_p3" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.10014267" displayUnit="1/cm">
+                <Parameter id="KZAi_A3P9k-iQLgfitQDUA" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="6.6">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                  <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
+                  <Info min="0" max="14" flag="122" seq="1" ref="0" bb="32" group="41" />
                 </Parameter>
-                <Parameter id="dy7IAnoA70-LxQoJkj4hjg" name="Thickness_p1" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.00665" displayUnit="cm">
+                <Parameter id="7igTptbqQEK9NgykHK7u2Q" name="r1_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0384322177" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="nJLa348wqkW9dkJSE9an9g" name="r2_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.005597402">
+                <Parameter id="pC0SPhcU8UqDK5ec4tlDfQ" name="r1_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.008955843">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="9CQtu3kxZk6mg_Wvtk4TIw" name="r2_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0240201361" displayUnit="cm">
+                <Parameter id="iNLhCW5XdEaQ5f02Ys8WYg" name="r2_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0240201361" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="E6Dm9E8YzUiI1II6gVQvoA" name="r1_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.008955843">
+                <Parameter id="RKiQM5rcHEORCkPfKnutDw" name="r2_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.005597402">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="N5DBK9mpcUiqJAVFoQBwNA" name="r1_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0384322177" displayUnit="cm">
+                <Parameter id="R9AGvK87kE6wN_eox032mQ" name="Thickness_p1" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.00665" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
                 </Parameter>
-                <Parameter id="hiOmxQH5Jkqv8Ph0b2-JjA" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="6.6">
+                <Parameter id="xG_BYCHYlkWbcoeQLuIcJg" name="Thickness_p2" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0324721331" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
-                  <Info min="0" max="14" flag="122" seq="1" ref="0" bb="32" group="41" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
                 </Parameter>
-                <DistributedParameter id="cydLfQpzdUKJrQIfOUoksQ" name="Effective surface area enhancement factor" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="VhQDV40WKEiwwQo4YyUR1A" mode="Logical" isDefault="1">
+                <Parameter id="Ilx-jWtZ5U61WXmt0qLDvA" name="Thickness_p3" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.10014267" displayUnit="1/cm">
+                  <Tags>
+                    <Tag value="Lumen" />
+                    <Tag value="LumenSegment" />
+                  </Tags>
+                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                </Parameter>
+                <DistributedParameter id="NlItqhxXDEmLEltEkKM_dg" name="Effective surface area enhancement factor" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="PGcnySdO0U-1REbD-FzA1A" mode="Logical" isDefault="1">
                   <Children>
-                    <Parameter id="h7-gqsz2SEGaJagTrqX6Sg" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                    <Parameter id="sbmL9oFnYk6qZWM2t2PH7A" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
                       <Info min="0" flag="18" seq="1" ref="0" bb="32" group="32" />
                     </Parameter>
-                    <Parameter id="yXnCxCk14EmQBRHjHHhkuQ" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="3.56">
+                    <Parameter id="4Fpay4tTe0K_6Avy1gnDwQ" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="3.56">
                       <Info min="0" flag="50" seq="1" ref="0" bb="32" group="32" />
                     </Parameter>
                   </Children>
@@ -6597,123 +6647,127 @@
                   </Tags>
                   <Info min="0" flag="122" seq="1" ref="0" bb="32" group="32" />
                 </DistributedParameter>
-                <Container id="RV4JT79Ng0er9COZS9ugHw" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="H5u8BossPUiD7xM5Nx-5_A" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                   <Children>
-                    <Parameter id="EYqe67AilUyKF3iTzDFBCw" name="Solubility table" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.TableFormulaWithXArgument_SolubilityTable" isDefault="1" displayUnit="mg/l">
-                      <Info min="0" flag="50" seq="1" ref="0" bb="2" group="42" />
-                    </Parameter>
-                    <Parameter id="XWRIfVZrkk2b1IaulYdN6w" name="Solubility_pKa_pH_Factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" isDefault="1">
-                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="18" />
-                    </Parameter>
-                    <Parameter id="GucU9md1J060M4kiz9TBgg" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
-                      <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
-                    </Parameter>
-                    <Parameter id="ESLNNtz7c0mUccnn7EDOOA" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" isDefault="1">
-                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
-                    </Parameter>
-                    <Parameter id="1xyjXEsd0k-03zfol_71Vw" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" isDefault="1">
-                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
-                    </Parameter>
-                    <Parameter id="79Wx9A8SnE6-9e6Kx5SuOQ" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal_GI" isDefault="1">
+                    <Parameter id="LDzFNe1_OEuHg7f5ghxapQ" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal_GI" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                     </Parameter>
-                    <Parameter id="r_BPQv1acEC4b3i2k7ZEug" name="Oral mass absorbed segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" rHSFormula="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_rect" value="0" displayUnit="µmol">
+                    <Parameter id="YOdsD1tdNkWysmlKXxIMfw" name="Oral mass absorbed segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" rHSFormula="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_rect" value="0" displayUnit="µmol">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                     </Parameter>
-                    <Parameter id="nH08ooCpQ0KDqwNasQ5gNQ" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                    <Parameter id="_XCWciJUBEKnwp192VqphA" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                     </Parameter>
-                    <Parameter id="90cX6wg4nU2ujdCT0y0HzA" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" isDefault="1">
+                    <Parameter id="XwjO5gdcKEy_KAHTB6zarw" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="OHdKgYXlvE-zIeG-jvCFVA" name="Solubility" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_IntestinalSolubility" isDefault="1" displayUnit="mg/l">
-                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="42" />
+                    <Parameter id="Ez3mt4V1pEWkbx8QZCoQ4g" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                    </Parameter>
+                    <Parameter id="dt-VQfvQlESFrfSBamzw5g" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="3Oa4_IIXsUCrFidzKTih5w" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" isDefault="1">
+                    <Parameter id="YBofUY-1YkmXyDKnCb7E-w" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="D7sFlXCpd0qp9ILuuSG3yQ" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" isDefault="1">
+                    <Parameter id="sI-SjYnZeUmNaBq5cQyU1g" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="e2PSH0H6g0iiwOnSw6964A" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" isDefault="1">
+                    <Parameter id="xxk0dkrIVEusyLeJ87DmeQ" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="yUE-_e_7iUybLTOY3n4TwA" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" isDefault="1">
+                    <Parameter id="kMNmGssu40CmQDOAk28akw" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="FxiltVo24U6GImX0_k-dlg" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" isDefault="1">
+                    <Parameter id="hbIy_L0ikUm6WlA8l2hCIg" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="mY74xLoDe0aCjbMAxmkDEg" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" isDefault="1">
+                    <Parameter id="xf4hfjaHkUeRUsju75NMwQ" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="l5dWn5a7102nTzPr32UorQ" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" isDefault="1">
+                    <Parameter id="_XxQn-rVSkmcWQbUmSEltA" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="jUSQ-opjYUOhis9BNTmMjg" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" isDefault="1">
+                    <Parameter id="J-ixQhw3JU6HKuHKKzEasg" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
+                    <Parameter id="bcUpzX0PLEStrGSv4H6a7A" name="Solubility" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_IntestinalSolubility" isDefault="1" displayUnit="mg/l">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="42" />
+                    </Parameter>
+                    <Parameter id="oHSlujTnVEOcSp1h9ke9-w" name="Solubility table" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.TableFormulaWithXArgument_SolubilityTable" isDefault="1" displayUnit="mg/l">
+                      <Info min="0" flag="50" seq="1" ref="0" bb="2" group="42" />
+                    </Parameter>
+                    <Parameter id="bblZ4cYvaUi4HDUtDqeovQ" name="Solubility_pKa_pH_Factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" isDefault="1">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="18" />
+                    </Parameter>
+                    <Parameter id="mk16ImSMykyJzqjiOqYv4w" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                      <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                    </Parameter>
+                    <Parameter id="iCExWQOS-UaoBz3xS3CWUg" name="Effective concentration in lumen" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_EffectiveLumenConcentration" isDefault="1" displayUnit="µmol/l">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="42" />
+                    </Parameter>
                   </Children>
                 </Container>
               </Children>
             </Container>
-            <Container id="9lTL_VWE0Ui8vKfdUBrZDQ" name="Feces" mode="Physical" containerType="Compartment">
+            <Container id="ffDERjBcLEWuvmggak6aTQ" name="Feces" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="Lumen" />
                 <Tag value="LumenSegment" />
               </Tags>
               <Children>
-                <Parameter id="SJiOdPJ2bE2NnK4PDGoHSQ" name="Liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" rHSFormula="Lumen_PKSim.LiquidRHS_fec" value="0" displayUnit="l">
+                <Parameter id="KMR8MjrLXESvZJEfNTN_Sg" name="Liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" rHSFormula="Lumen_PKSim.LiquidRHS_fec" value="0" displayUnit="l">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="dfTlmFQ8Ck2rCBwgkhRX8Q" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="l">
+                <Parameter id="0C8-tqmiEUOY3P5kAZSUzw" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="l">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="56" />
                 </Parameter>
               </Children>
             </Container>
           </Children>
         </Container>
-        <Container id="fd2OZzHAv0qtEpiXwXgr5w" name="Stomach" mode="Logical" containerType="Organ">
+        <Container id="srIGE52d5kS7-In2gTAoRA" name="Stomach" mode="Logical" containerType="Organ">
           <Tags>
             <Tag value="Portal Vein Supplying Organ" />
             <Tag value="TissueOrgan" />
           </Tags>
           <Children>
-            <Parameter id="glw1s4J5tUmgK3zQHoIw-A" name="Fraction of endosomal uptake from plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_uptake_vas" isDefault="1">
+            <Parameter id="n8XEjeKelEOFFtz4_YhaFg" name="Fraction of endosomal uptake from plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_uptake_vas" isDefault="1">
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
               <Info min="0" flag="54" seq="0" ref="0" bb="2" group="25" />
             </Parameter>
-            <Parameter id="cBA8YC8ZAEuKxdgWs58UYw" name="Fraction endosomal" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_endo" isDefault="1">
+            <Parameter id="SShcUUc5-EaTOgKTbhizTw" name="Fraction endosomal" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_endo" isDefault="1">
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
               <Info min="0" max="1" flag="54" seq="1" ref="0" bb="2" group="29" />
             </Parameter>
-            <Parameter id="J5mr0cqwb0SZnlLPExFH4A" name="Rate constant for recycling from endosomal space" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_K_rec" isDefault="1" displayUnit="1/min">
+            <Parameter id="-Ifa7BNLbUmQpofyH-gpeg" name="Fraction recycled to plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_rec_vas" isDefault="1">
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
               <Info min="0" flag="54" seq="1" ref="0" bb="2" group="25" />
             </Parameter>
-            <Parameter id="96_TVzBfTkyKKvpwW5Xjag" name="Rate constant for endosomal uptake" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_K_uptake" isDefault="1" displayUnit="1/min">
+            <Parameter id="m3Y4OeMyQEmHJogPvr9NrQ" name="Rate constant for endosomal uptake" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_K_uptake" isDefault="1" displayUnit="1/min">
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
               <Info min="0" flag="54" seq="1" ref="0" bb="2" group="25" />
             </Parameter>
-            <Parameter id="vNDoGhfpr0uinRl_KxI0sw" name="Fraction recycled to plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_rec_vas" isDefault="1">
+            <Parameter id="zPs0oCbZUkGL-9_2BzverA" name="Rate constant for recycling from endosomal space" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_K_rec" isDefault="1" displayUnit="1/min">
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
               <Info min="0" flag="54" seq="1" ref="0" bb="2" group="25" />
             </Parameter>
-            <Parameter id="PvZyKyQiE0OJ5ChfoQpGRw" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
+            <Parameter id="IPpenV6mh02OFbRzP_nPAw" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
             </Parameter>
-            <Parameter id="0QdC4PGRxkiz2vVC6lMXZQ" name="Volume (endothelium)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="VascularEndoVolume.VOLUME_VascularEndo_sto" isDefault="1" displayUnit="l">
+            <Parameter id="eWhHTPaXyka3Akzr90q2fw" name="Fluid recirculation flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate" isDefault="1" displayUnit="l/min">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
-              <Info min="0" flag="62" seq="14" ref="0" bb="32" group="127" />
+              <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+              <Info min="0" flag="122" seq="14" ref="0" bb="32" group="27" />
             </Parameter>
-            <Parameter id="d4RyqM942USCziP3UrjvDA" name="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Lymph_flow_rate" isDefault="1" displayUnit="l/min">
+            <Parameter id="0svWOwkpvkCxwH4sBZbqRg" name="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Lymph_flow_rate" isDefault="1" displayUnit="l/min">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
@@ -6721,111 +6775,111 @@
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
               <Info min="0" flag="122" seq="14" ref="0" bb="32" group="58" />
             </Parameter>
-            <Parameter id="rGB6OF4UhEat2F_7jMHpmg" name="Fluid recirculation flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate" isDefault="1" displayUnit="l/min">
+            <Parameter id="74aHSXYrGk6q5h8Il1SnOQ" name="Volume (endothelium)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="VascularEndoVolume.VOLUME_VascularEndo_sto" isDefault="1" displayUnit="l">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
-              <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-              <Info min="0" flag="122" seq="14" ref="0" bb="32" group="27" />
+              <Info min="0" flag="62" seq="14" ref="0" bb="32" group="127" />
             </Parameter>
-            <Parameter id="c02WL59Gt0i5FJA13jyoBA" name="Fraction intracellular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_f_cell" isDefault="1">
+            <Parameter id="2ZM11h2alEK2EUWHiDkNuw" name="Fraction intracellular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_f_cell" isDefault="1">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" max="1" flag="62" seq="43" ref="0" bb="32" group="64" />
             </Parameter>
-            <Parameter id="rwYTK3K9U0qfS6TxxQZGkw" name="Blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_from_Qspec" isDefault="1" displayUnit="l/min">
+            <Parameter id="S6c1dV4_lUi3E0CSdtgUCg" name="Blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_from_Qspec" isDefault="1" displayUnit="l/min">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
-              <ValueOrigin id="48" description="TODO: Absolute from specific calculation" />
+              <ValueOrigin id="48" source="Other" description="Absolute value = specific value (i.e. value normalized to the volume of the organ) multiplied by the organ volume" />
               <Info min="0" flag="62" seq="262" ref="0" bb="32" group="5" />
             </Parameter>
-            <Parameter id="BtN-_HEQc0mRWD_veiJJLQ" name="Density (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
+            <Parameter id="9Li4o3UMK0qWCnM-3maTwA" name="Density (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" flag="38" seq="1" ref="0" bb="32" group="21" />
             </Parameter>
-            <Parameter id="poYbXJcfHUGG9tdpF8Gxlg" name="Fluid recirculation flow proportionality factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.96">
+            <Parameter id="hfvyX7fx-ECS_UyfuxewLA" name="Fluid recirculation flow proportionality factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.96">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" flag="54" seq="1" ref="0" bb="32" group="27" />
             </Parameter>
-            <Parameter id="BpQKDi_DXE-FRg25jRdRgg" name="Lymph flow proportionality factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.00204">
+            <Parameter id="htqhe4rSzEOxtiU54OmFxw" name="Lymph flow proportionality factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.00204">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" flag="54" seq="1" ref="0" bb="32" group="58" />
             </Parameter>
-            <Parameter id="-8zLqN6yc0mzVhGksc44qA" name="Organ volume mouse" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.00011" displayUnit="l">
+            <Parameter id="0f_E94tKzke981lfxeQ2yw" name="Organ volume mouse" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.00011" displayUnit="l">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" flag="54" seq="1" ref="0" bb="32" group="65" />
             </Parameter>
-            <Parameter id="QiaIwh413UeKpgKOYGfMFQ" name="Allometric scale factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.75">
+            <Parameter id="KNe3N1ObykukGuUbsy0-Og" name="Allometric scale factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.75">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0.75" max="0.75" flag="54" seq="1" ref="0" bb="32" group="2" />
             </Parameter>
-            <Parameter id="keMcmFtgZkCfabcsCYOoDA" name="Fraction of blood for sampling" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+            <Parameter id="Dl2MU5wv4E2i3quSnKZoWw" name="Fraction of blood for sampling" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" max="1" flag="54" seq="1" ref="0" bb="32" group="94" />
             </Parameter>
-            <Parameter id="q4SQkkupZkGJFiyZO5w4FQ" name="Hydraulic conductivity" icon="Parameter" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="3.97222222222222E-11" displayUnit="ml/min/N">
+            <Parameter id="asER-NtgaE2j1fAtrDqbAg" name="Flow fraction via large pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.05">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-              <Info min="0" flag="122" seq="14" ref="0" bb="32" group="115" />
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             </Parameter>
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+                <Parameter id="I1YS1ujAD0OYrZ1aWxYOIQ" name="Deviation" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.025271500392" displayUnit="l">
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@@ -6994,17 +7047,18 @@
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
+              <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
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+            <DistributedParameter id="vPoJO504o0mZ1LiOGQl0GA" name="Specific blood flow rate" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" formula="zlgzPdkjFkin7emU3wBlxw" mode="Logical" isDefault="1" displayUnit="ml/min/100g organ">
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+                <Parameter id="jiOQWR7Qgk6_5Ze5hr_yDw" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5" displayUnit="ml/min/100g organ">
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                 </Parameter>
-                <Parameter id="7ejyOSbjZ0yx7bchGZOVnA" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.3861" displayUnit="ml/min/100g organ">
+                <Parameter id="MzfG_XWQPU-Rn4BM42YXtA" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.3861" displayUnit="ml/min/100g organ">
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                 </Parameter>
-                <Parameter id="lMofMH1YAEWJz_AduG3nbg" name="Deviation" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.019305" displayUnit="ml/min/100g organ">
+                <Parameter id="Z4b_-VRnMkWzTdGWqQOAWA" name="Deviation" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.019305" displayUnit="ml/min/100g organ">
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                 </Parameter>
               </Children>
@@ -7012,181 +7066,182 @@
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
+              <ValueOrigin id="40" source="Publication" description="Edginton, A.N., Schmitt, W. &amp; Willmann, S. Clin Pharmacokinet (2006) 45: 1013. https://doi.org/10.2165/00003088-200645100-00005" />
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             </DistributedParameter>
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+            <Container id="1Y1b2vLN9kKD2bFVFJvlPA" name="Plasma" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="Stomach" />
               </Tags>
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+                <Parameter id="VA-rRopZ5ESHugBx64-cLg" name="FcRn concentration in container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.FcRn_in_Container_Plasma" isDefault="1" displayUnit="µmol/l">
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                 </Parameter>
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+                <Parameter id="2pMEA3JwvE2dHZ95uY08pA" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                  <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                </Parameter>
+                <Parameter id="rsIOOnI3NEeqhbEL-W5GrA" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_pls_2Pores" isDefault="1" displayUnit="l">
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                 </Parameter>
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+                <Container id="vv_YtsAZwkm-3MjIVFnh8w" name="MoleculeProperties" mode="Logical" containerType="Molecule">
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-                    <Parameter id="V2IpwMT7V06SNjuF1nTwXg" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Plasma_and_Interstitial" isDefault="1" displayUnit="µmol/l">
+                    <Parameter id="Sc3HF-0m_EatyRUBhfFySg" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Plasma_and_Interstitial" isDefault="1" displayUnit="µmol/l">
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+                    <Parameter id="9Ud2G3a21U2iEI5N4WNpAA" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
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+                    <Parameter id="19hySHyFwE6fu79kzeq_Zg" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" isDefault="1">
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                     </Parameter>
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+                    <Parameter id="4ezuYPW4GUGEeeemzPOQXQ" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
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             </Container>
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               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
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+                <Parameter id="is5RUdd7FEeoSmIZLI4vyw" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
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+                <Parameter id="LveKgtYbfUqFDRmAFE-8jg" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_bc_2Pores" isDefault="1" displayUnit="l">
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                 </Parameter>
-                <Container id="pffaMqF2TUOe4qspFGvM0A" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="OnyekPh9qkm1ylMEdjMoZA" name="MoleculeProperties" mode="Logical" containerType="Molecule">
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+                    <Parameter id="zGFV25kja0mzIQPbLAjUvQ" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
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+                    <Parameter id="w8tt_OKM8ka6KcSu01I6eA" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" isDefault="1">
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                     </Parameter>
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+                    <Parameter id="WStWNd0Ys06sHiur8mrvxg" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
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+            <Container id="idjRJQZ_5EiU4vye5ioKFQ" name="Interstitial" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="Stomach" />
               </Tags>
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+                <Parameter id="dltbc314i0OIa6lFdD9UeA" name="FcRn concentration in container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.FcRn_in_Container_Interstitial" isDefault="1" displayUnit="µmol/l">
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                 </Parameter>
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+                <Parameter id="m71KlHNeI02AeLJuCXNNEw" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
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                 </Parameter>
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+                <Parameter id="hhB9f0Ru7EiNexwIyvbM-w" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_int_2Pores" isDefault="1" displayUnit="l">
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-                <Parameter id="1yvnPhNE0EWG4N0QxC6ZZA" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_pH_INT" isDefault="1">
+                <Parameter id="2y2RbsojxEiSEx75-sWf3A" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_pH_INT" isDefault="1">
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                 </Parameter>
-                <Container id="q9NhLfAURkO9jPgNTjKWXA" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="Kv4qYHI0yUyavKzZboWOqA" name="MoleculeProperties" mode="Logical" containerType="Molecule">
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+                    <Parameter id="IEz8bpzu-0eGFvSyyUC3sw" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Plasma_and_Interstitial" isDefault="1" displayUnit="µmol/l">
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+                    <Parameter id="Fyxc0eJ7vkCNmM1ieMcV_Q" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
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+                    <Parameter id="ZhKVeIUcikeMEBY8wpYlZw" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_sto" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                     </Parameter>
+                    <Parameter id="bUiPbFXzMUi4yxyTDFiiGQ" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
+                      <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                    </Parameter>
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+            <Container id="DvjhtxZc7k-0GXmDzJwKBQ" name="Intracellular" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
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               </Tags>
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+                <Parameter id="v7dOe1vm0Ui06Y9z0tzxMw" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" isDefault="1" displayUnit="l">
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+                <Parameter id="UDsK3j0fs0CS4Hhlja6bLg" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_cell_2Pores" isDefault="1" displayUnit="l">
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                 </Parameter>
-                <Parameter id="DOvvhXswkUG1BLpEr2XIdg" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.4">
+                <Parameter id="9f_KBaD5okS_X9O80hROnA" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.4">
                   <Tags>
                     <Tag value="Portal Vein Supplying Organ" />
                     <Tag value="Stomach" />
                   </Tags>
                   <Info min="0" max="14" flag="122" seq="44" ref="0" bb="32" group="83" />
                 </Parameter>
-                <Container id="Vzkw8N2m2ku8GNoI9Rj2Wg" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="lLAkfRqOsEGWOOgvJSpqfg" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                   <Children>
-                    <Parameter id="cjGGscf1ak-SUwPXZWKzfA" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                    <Parameter id="JjjxzV_5xEG7rnoBlyBKUQ" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                     </Parameter>
-                    <Parameter id="kYq5MdjYhk-F-QGRzHaPVQ" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_sto" isDefault="1">
+                    <Parameter id="ewfC9EhS_0-TZGy79asn6w" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_sto" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                     </Parameter>
-                    <Parameter id="lWzrFfb-tU-gnvI0P50IoA" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
+                    <Parameter id="h4VHGM5bzEGorsTTJeZqTw" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
                       <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                     </Parameter>
                   </Children>
                 </Container>
               </Children>
             </Container>
-            <Container id="ISBNb6AmZkqpaut8DG_4Aw" name="Endosome" mode="Physical" containerType="Compartment">
+            <Container id="NSFAoupKckm-s-PO7GFRdg" name="Endosome" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="Stomach" />
               </Tags>
               <Children>
-                <Parameter id="9faV4-x-10m9tDvAeujR5w" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
-                  <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
-                </Parameter>
-                <Parameter id="tgKd3MX7Y0GTOePbhoPctg" name="FcRn concentration in container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.FcRn_in_Container_Endosomal" isDefault="1" displayUnit="µmol/l">
+                <Parameter id="m3OrMZItPkCxHsWy5Y7asA" name="FcRn concentration in container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.FcRn_in_Container_Endosomal" isDefault="1" displayUnit="µmol/l">
                   <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                   <Info flag="52" seq="1" ref="0" bb="2" group="25" />
                 </Parameter>
-                <Parameter id="59YSuHsGoUub34s9vQ2Nuw" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_end_sto" isDefault="1" displayUnit="l">
+                <Parameter id="1IhuLbuYikqcmjjg5C1xYQ" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                  <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                </Parameter>
+                <Parameter id="tGbp9eupZEqgL9TQy6X5cA" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_end_sto" isDefault="1" displayUnit="l">
                   <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                   <Info min="0" flag="122" seq="14" ref="0" bb="2" group="123" />
                 </Parameter>
-                <Container id="LBRXnrBkdUebVAov-Ru5zQ" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="ZSQdIliZU0Wh4zIMn-I1bw" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                   <Children>
-                    <Parameter id="5gOFhg-MTUekfKdSrE1FyQ" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Endosomal" isDefault="1" displayUnit="µmol/l">
+                    <Parameter id="zrsMV-dEm0-1rBfIInyx-A" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Endosomal" isDefault="1" displayUnit="µmol/l">
                       <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                       <Info flag="52" seq="1" ref="0" bb="2" group="25" />
                     </Parameter>
-                    <Parameter id="xhuomYG4fUSG0ogeCjssmw" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                    <Parameter id="yZ0vcRxiakCCg2nK5n9_IQ" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                     </Parameter>
-                    <Parameter id="_GQydmu1akq0hr6LBcbMNQ" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                    <Parameter id="oImGfGAF20KFepqTnAiBNw" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
                       <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                     </Parameter>
-                    <Parameter id="NS5Xp2OrqUCynzT_GN3rTQ" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
+                    <Parameter id="5nDClzytYkaStJynE-MgtQ" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
                       <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                     </Parameter>
                   </Children>
@@ -7195,47 +7250,47 @@
             </Container>
           </Children>
         </Container>
-        <Container id="d6HPIth_Y0S3VXBdF1jmHg" name="SmallIntestine" mode="Logical" containerType="Organ">
+        <Container id="JZ4gN3rfKU-Lera0Hxzz_w" name="SmallIntestine" mode="Logical" containerType="Organ">
           <Tags>
             <Tag value="Portal Vein Supplying Organ" />
             <Tag value="TissueOrgan" />
           </Tags>
           <Children>
-            <Parameter id="Vnt3gLs23kSbty_SLKOGug" name="Fraction of endosomal uptake from plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_uptake_vas" isDefault="1">
+            <Parameter id="aYykD4MmE02Grf0IgmnWSg" name="Fraction of endosomal uptake from plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_uptake_vas" isDefault="1">
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
               <Info min="0" flag="54" seq="0" ref="0" bb="2" group="25" />
             </Parameter>
-            <Parameter id="2U6aIxPrp0eUXamguMmO9w" name="Rate constant for endosomal uptake" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_K_uptake" isDefault="1" displayUnit="1/min">
+            <Parameter id="9HB-2Ro3hUqTiL-7q66rbg" name="Fraction endosomal" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_endo" isDefault="1">
+              <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+              <Info min="0" max="1" flag="54" seq="1" ref="0" bb="2" group="29" />
+            </Parameter>
+            <Parameter id="af5y9jR65Eykad0EYdPb0w" name="Fraction recycled to plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_rec_vas" isDefault="1">
+              <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+              <Info min="0" flag="54" seq="1" ref="0" bb="2" group="25" />
+            </Parameter>
+            <Parameter id="XXiIs9vFnESNE2GOBHFT3w" name="Rate constant for endosomal uptake" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_K_uptake" isDefault="1" displayUnit="1/min">
+              <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+              <Info min="0" flag="54" seq="1" ref="0" bb="2" group="25" />
+            </Parameter>
+            <Parameter id="OZbcpU0C6kaGMNHjiQiXCw" name="Rate constant for recycling from endosomal space" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_K_rec" isDefault="1" displayUnit="1/min">
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
               <Info min="0" flag="54" seq="1" ref="0" bb="2" group="25" />
             </Parameter>
-            <Parameter id="tRgrx0eRVUWtLF-bS5eoIw" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
+            <Parameter id="mQLewbLJukOquUbP6OsXVw" name="Small intestinal transit time factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_SITT_Factor" isDefault="1">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
-              <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
+              <Info min="0" flag="38" seq="1" ref="0" bb="32" group="46" />
             </Parameter>
-            <Parameter id="m_Ju_wsN6E6ahyFWRIQ-sg" name="Small intestinal transit time factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_SITT_Factor" isDefault="1">
+            <Parameter id="mbc-Qt3dfEKbLpiaPabqqQ" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
-              <Info min="0" flag="38" seq="1" ref="0" bb="32" group="46" />
-            </Parameter>
-            <Parameter id="IGyG8x-t2EK8VMEd8_hkrA" name="Rate constant for recycling from endosomal space" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_K_rec" isDefault="1" displayUnit="1/min">
-              <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-              <Info min="0" flag="54" seq="1" ref="0" bb="2" group="25" />
-            </Parameter>
-            <Parameter id="Gls2c_zD3kKNlIIx7qdf3w" name="Fraction recycled to plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_rec_vas" isDefault="1">
-              <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-              <Info min="0" flag="54" seq="1" ref="0" bb="2" group="25" />
-            </Parameter>
-            <Parameter id="yAVMW3ti_0CY4M-d7sj5Uw" name="Fraction endosomal" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_endo" isDefault="1">
-              <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-              <Info min="0" max="1" flag="54" seq="1" ref="0" bb="2" group="29" />
+              <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
             </Parameter>
-            <Parameter id="SekR62ahXkONwOG0DZSB4w" name="Fluid recirculation flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_FluidRecirculationRate_sin" isDefault="1" displayUnit="l/min">
+            <Parameter id="gbL76I0nqUayTEH7ZbvEfw" name="Fluid recirculation flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_FluidRecirculationRate_sin" isDefault="1" displayUnit="l/min">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
@@ -7243,123 +7298,123 @@
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
               <Info min="0" flag="62" seq="15" ref="0" bb="32" group="27" />
             </Parameter>
-            <Parameter id="bTqwArnEG067Adjoa_xybw" name="Volume (endothelium)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="VascularEndoVolume.VOLUME_VascularEndo_sin" isDefault="1" displayUnit="l">
+            <Parameter id="OOtGiJlq802SCszO2DcC4g" name="Fluid recirculation flow rate (incl. mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate" isDefault="1" displayUnit="l/min">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
-              <Info min="0" flag="62" seq="15" ref="0" bb="32" group="127" />
+              <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+              <Info min="0" flag="122" seq="15" ref="0" bb="32" group="27" />
             </Parameter>
-            <Parameter id="g6jktfVQ2kqpMuLs4l3jdA" name="Fluid recirculation flow rate (incl. mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate" isDefault="1" displayUnit="l/min">
+            <Parameter id="b_WOpEZlW0mU7efeGzCdIg" name="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_Lymph_sin" isDefault="1" displayUnit="l/min">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-              <Info min="0" flag="122" seq="15" ref="0" bb="32" group="27" />
+              <Info min="0" flag="62" seq="15" ref="0" bb="32" group="58" />
             </Parameter>
-            <Parameter id="Byi6kc21vEiNh8_YENRcsg" name="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_Lymph_sin" isDefault="1" displayUnit="l/min">
+            <Parameter id="00G4YTSB_E6EOUJ65UkcsA" name="Lymph flow rate (incl. mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Lymph_flow_rate" isDefault="1" displayUnit="l/min">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-              <Info min="0" flag="62" seq="15" ref="0" bb="32" group="58" />
+              <Info min="0" flag="122" seq="15" ref="0" bb="32" group="58" />
             </Parameter>
-            <Parameter id="IYvWCZs4pUCCtyxV9XRVnQ" name="Lymph flow rate (incl. mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Lymph_flow_rate" isDefault="1" displayUnit="l/min">
+            <Parameter id="bwK6575SbEypk_0-uYmjfw" name="Volume (endothelium)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="VascularEndoVolume.VOLUME_VascularEndo_sin" isDefault="1" displayUnit="l">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
-              <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-              <Info min="0" flag="122" seq="15" ref="0" bb="32" group="58" />
+              <Info min="0" flag="62" seq="15" ref="0" bb="32" group="127" />
             </Parameter>
-            <Parameter id="KRYiA38HD0aZYfl2QEh2gg" name="Fraction intracellular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_f_cell" isDefault="1">
+            <Parameter id="ysQ1ZfXz10qJdkuGWbHGQw" name="Fraction intracellular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_f_cell" isDefault="1">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" max="1" flag="62" seq="46" ref="0" bb="32" group="64" />
             </Parameter>
-            <Parameter id="thych1fiQ0SRTYg18NUYFg" name="Blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_from_Qspec" isDefault="1" displayUnit="l/min">
+            <Parameter id="EoFhkZVKWE6n9cjIkiyjVg" name="Blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_from_Qspec" isDefault="1" displayUnit="l/min">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
-              <ValueOrigin id="48" description="TODO: Absolute from specific calculation" />
+              <ValueOrigin id="48" source="Other" description="Absolute value = specific value (i.e. value normalized to the volume of the organ) multiplied by the organ volume" />
               <Info min="0" flag="62" seq="222" ref="0" bb="32" group="5" />
             </Parameter>
-            <Parameter id="drY1KeeUskagdP551DWnoQ" name="Volume (mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="MucosaVolume.VOLUME_SmallIntestineMucosa" isDefault="1" displayUnit="l">
+            <Parameter id="pD8AD2Act02PEC4_6Uxq0w" name="Volume (mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="MucosaVolume.VOLUME_SmallIntestineMucosa" isDefault="1" displayUnit="l">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
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                 <Tag value="TissueOrgan" />
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                 <Tag value="TissueOrgan" />
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                 <Tag value="TissueOrgan" />
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                 <Tag value="TissueOrgan" />
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@@ -7367,23 +7422,23 @@
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+            <Parameter id="nab_IF8rJ0OrRzNerBX57g" name="Hydraulic conductivity" icon="Parameter" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.53888888888889E-10" displayUnit="ml/min/N">
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+              <Info min="0" flag="122" seq="15" ref="0" bb="32" group="115" />
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+            <Parameter id="pgJh8La3gE-AMkoBBoyUOw" name="Radius (large pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.5E-07" displayUnit="µm">
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+            <Parameter id="karUSShqcEubUK1dwNkE4Q" name="Radius (small pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="4.5E-08" displayUnit="µm">
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+            <Parameter id="Q90TVIaGF0OSFz77FHGRGw" name="Fraction vascular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.024">
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@@ -7429,54 +7484,54 @@
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+            <Parameter id="RiWotn64lESxMSQ0_DV1eg" name="Albumin ratio (tissue/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.158">
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@@ -7484,14 +7539,14 @@
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+            <Parameter id="l_8MPTVk6kKYjO8bkSWnbQ" name="Vf (neutral phospholipid)-RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0124">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
@@ -7499,29 +7554,29 @@
               <ValueOrigin id="22" source="Publication" description="Rodgers T, Rowland M. Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J Pharm Sci. 2006 Jun;95(6):1238-57 https://doi.org/10.1002/jps.20502" />
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+            <Parameter id="I5_bK89M30mholia1blNZA" name="Vf (neutral phospholipid, plasma)-WS" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0182">
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+            <Parameter id="8tfWm8nboEegKJoMsw__EA" name="Vf (extracellular water)-RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.282">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
-              <Info min="0" max="1" flag="122" seq="77" ref="0" bb="32" group="95" />
+              <ValueOrigin id="21" source="Publication" description="Rodgers T, Leahy D, Rowland M. Physiologically based pharmacokinetic modeling 1: predicting the tissue distribution of moderate-to-strong bases. J Pharm Sci. 2005 Jun;94(6):1259-76. https://doi.org/10.1002/jps.20322" />
+              <Info min="0" max="1" flag="122" seq="77" ref="0" bb="32" group="92" />
             </Parameter>
-            <Parameter id="fy2tvZIvx0GuyrsxxQ1ytQ" name="Vf (extracellular water)-RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.282">
+            <Parameter id="YVFEwt0nokykRxRdbx2fXg" name="Vf (protein)-WS" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.15">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
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-              <Info min="0" max="1" flag="122" seq="77" ref="0" bb="32" group="92" />
+              <Info min="0" max="1" flag="122" seq="77" ref="0" bb="32" group="95" />
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-            <Parameter id="Q-Kk4xXehECfhqC7QVEbWw" name="Vf (intracellular water)-RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.456">
+            <Parameter id="cCVzBzTVY0C4ewRlDHmCQg" name="Vf (intracellular water)-RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.456">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
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@@ -7529,14 +7584,14 @@
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+            <Parameter id="P1Q02IVXK06bKI1B34k12A" name="Vf (water)-WS" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.78">
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                 <Tag value="TissueOrgan" />
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-            <Parameter id="ccLZ41AL2EqgZ0U8FM6saA" name="Acidic phospholipids [mg/g] - RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.41">
+            <Parameter id="R1QuCNGCtkOKqV-Pz7MFLw" name="Acidic phospholipids [mg/g] - RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.41">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
@@ -7544,22 +7599,22 @@
               <ValueOrigin id="21" source="Publication" description="Rodgers T, Leahy D, Rowland M. Physiologically based pharmacokinetic modeling 1: predicting the tissue distribution of moderate-to-strong bases. J Pharm Sci. 2005 Jun;94(6):1259-76. https://doi.org/10.1002/jps.20322" />
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+            <Parameter id="vrdT9TPAzEiYplAzCori3w" name="Vf (acidic phospholipids)-WS" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0035">
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                 <Tag value="TissueOrgan" />
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               <Info min="0" max="1" flag="122" seq="79" ref="0" bb="32" group="95" />
             </Parameter>
-            <DistributedParameter id="RYjrwy5tpkuGlOnDYNR3jA" name="Small intestinal transit time" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="WedGylfYV0i5LZJTt8-7Gw" mode="Logical" isDefault="1" displayUnit="h">
+            <DistributedParameter id="ZFQ6olJPgUKS0JzyFfLXjg" name="Small intestinal transit time" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="lxvWSnnD8kG6kh6s9tmERQ" mode="Logical" isDefault="1" displayUnit="h">
               <Children>
-                <Parameter id="0cML_DBR-UWODR1WJG6dmQ" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5" displayUnit="h">
+                <Parameter id="nPowwW6n6kKdCYMhIjQhBw" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5" displayUnit="h">
                   <Info min="0" flag="18" seq="1" ref="0" bb="32" group="46" />
                 </Parameter>
-                <Parameter id="Mu_S8QDm7k25u3kV7YVIRg" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="126" displayUnit="h">
+                <Parameter id="MQWd2oEnzUuZktkVjEBZSw" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="126" displayUnit="h">
                   <Info min="27.2" max="1200" flag="50" seq="1" ref="0" bb="32" group="46" />
                 </Parameter>
-                <Parameter id="gWq950lXoEO02uq2tSxxLA" name="GeometricDeviation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.6">
+                <Parameter id="SoDE6884BEO5Muhq66pP5g" name="GeometricDeviation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.6">
                   <Info min="1" flag="18" seq="1" ref="0" bb="32" group="46" />
                 </Parameter>
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@@ -7569,15 +7624,15 @@
               </Tags>
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             </DistributedParameter>
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+            <DistributedParameter id="Nk_qL1ubX0aUp--R7f5yMA" name="Volume" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="IH3JKEPC-EGfkRseBrBhEQ" mode="Logical" isDefault="1" displayUnit="l">
               <Children>
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+                <Parameter id="oea69_6nH0uWJkDsKf_ABQ" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.502575498213435" displayUnit="l">
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                 </Parameter>
-                <Parameter id="THMVWRwWiEqXgnYpQ_h9Ww" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.58335271881664" displayUnit="l">
+                <Parameter id="VCLfaqQL9E6fqjFORmjk9w" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.7240974816" displayUnit="l">
                   <Info min="0" flag="34" seq="1" ref="0" bb="32" group="65" />
                 </Parameter>
-                <Parameter id="atmH-Z0A40O5SG9Phza-Hw" name="Deviation" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0682572317087829" displayUnit="l">
+                <Parameter id="v2zpYqZpn0yrLPkY8oAz3Q" name="Deviation" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.084725566517592" displayUnit="l">
                   <Info min="0" flag="18" seq="1" ref="0" bb="32" group="65" />
                 </Parameter>
               </Children>
@@ -7585,17 +7640,18 @@
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
+              <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
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             </DistributedParameter>
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+            <DistributedParameter id="EAF2FbE6aEGbd_oKr26lSQ" name="Specific blood flow rate" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" formula="Y2qbPLrH_kWAVlkJmLYbgQ" mode="Logical" isDefault="1" displayUnit="ml/min/100g organ">
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-                <Parameter id="O4Tymki050WHfjeE9eNh1Q" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5" displayUnit="ml/min/100g organ">
+                <Parameter id="6zEBVgixfUuh310ezdxTDQ" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5" displayUnit="ml/min/100g organ">
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                 </Parameter>
-                <Parameter id="QIoYHJipDkWuHK3mctkbnA" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.89765" displayUnit="ml/min/100g organ">
+                <Parameter id="xMfiXpyGRki9DdTB2xB3mw" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.89765" displayUnit="ml/min/100g organ">
                   <Info min="0" flag="50" seq="1" ref="0" bb="32" group="5" />
                 </Parameter>
-                <Parameter id="TPgk7cKASkKVTOnoLRdLPg" name="Deviation" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0448825" displayUnit="ml/min/100g organ">
+                <Parameter id="PSjVDvnCkEGDJwfXUy2CJw" name="Deviation" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0448825" displayUnit="ml/min/100g organ">
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                 </Parameter>
               </Children>
@@ -7603,423 +7659,424 @@
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
+              <ValueOrigin id="40" source="Publication" description="Edginton, A.N., Schmitt, W. &amp; Willmann, S. Clin Pharmacokinet (2006) 45: 1013. https://doi.org/10.2165/00003088-200645100-00005" />
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             </DistributedParameter>
-            <Container id="7_ch4FUOPEyotM_fc9eLow" name="Plasma" mode="Physical" containerType="Compartment">
+            <Container id="Bswuw2JsQ0muIVZwkoC_bA" name="Plasma" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="SmallIntestine" />
               </Tags>
               <Children>
-                <Parameter id="OdS8otNRx0SN-6pJ73DPZw" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
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-                </Parameter>
-                <Parameter id="LpKFta1Ds0GKmfViSLANpQ" name="FcRn concentration in container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.FcRn_in_Container_Plasma" isDefault="1" displayUnit="µmol/l">
+                <Parameter id="UMxlg6KZF0i47kycKOTTQw" name="FcRn concentration in container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.FcRn_in_Container_Plasma" isDefault="1" displayUnit="µmol/l">
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                 </Parameter>
-                <Parameter id="qKdW3dWCBEOPEBRyYxVwpg" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_pls_SinLin" isDefault="1" displayUnit="l">
+                <Parameter id="G0mGdOpfx0WhTO3AxTT58w" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                  <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                </Parameter>
+                <Parameter id="TP3y_l8hZ0WKic6EGU4tHw" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_pls_SinLin" isDefault="1" displayUnit="l">
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                   <Info min="0" flag="62" seq="15" ref="0" bb="2" group="126" />
                 </Parameter>
-                <Container id="x_NI2KoBkEWTJEZOvACEDg" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="RCAug9n6u0aHbTrhC5hU0w" name="MoleculeProperties" mode="Logical" containerType="Molecule">
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-                    <Parameter id="22jRCp6wtU2K2QELH0ZGrQ" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Plasma_and_Interstitial" isDefault="1" displayUnit="µmol/l">
+                    <Parameter id="z-gwLsoMv0SXoxYqdn57mQ" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Plasma_and_Interstitial" isDefault="1" displayUnit="µmol/l">
                       <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                       <Info flag="52" seq="1" ref="0" bb="2" group="25" />
                     </Parameter>
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+                    <Parameter id="fP4KR4_63UmD29wO-lSwbA" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                     </Parameter>
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+                    <Parameter id="ywiUa-5B6kKWsJNoQSL2zA" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                     </Parameter>
-                    <Parameter id="KlhXA6T9OUa7yvtIHJQ2AQ" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
+                    <Parameter id="uFThvCZhIku_9hRoMGNU4w" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
                       <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                     </Parameter>
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                 </Container>
               </Children>
             </Container>
-            <Container id="WBDJlNn9AEuNkbx1JbCoXQ" name="BloodCells" mode="Physical" containerType="Compartment">
+            <Container id="vXL46mJIE0uG18PXFjzX5g" name="BloodCells" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="SmallIntestine" />
               </Tags>
               <Children>
-                <Parameter id="9ENHqoMOH0S5oSFpQMAUfg" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                <Parameter id="KDzC8nq_fEiPff36kpjFiw" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
                   <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                 </Parameter>
-                <Parameter id="0fZRFoMgE0Kcp_z2lCAAkw" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_bc_SinLin" isDefault="1" displayUnit="l">
+                <Parameter id="nGpUePhXTEmfMLx2nO4eXQ" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_bc_SinLin" isDefault="1" displayUnit="l">
                   <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
                   <Info min="0" flag="62" seq="15" ref="0" bb="2" group="121" />
                 </Parameter>
-                <Container id="Wcbd7QD8MEaWbcRlKf0fwg" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="Otnw24BtgUK7XhbFxhYFeA" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                   <Children>
-                    <Parameter id="O3NwhPdcUEOsvrgyitlTZw" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                    <Parameter id="1Vw_LwneG02KwJySEWyM8Q" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
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                       <Info min="0" max="1" flag="122" seq="557" ref="0" bb="32" group="92" />
                     </Parameter>
-                    <Parameter id="9Q3JLzVyGU-PW2a9_79kxA" name="Vf (intracellular water)-RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.456">
+                    <Parameter id="k22wVgZIq0CdkX5ZR8IFMA" name="Vf (protein)-WS" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.15">
+                      <Info min="0" max="1" flag="122" seq="557" ref="0" bb="32" group="95" />
+                    </Parameter>
+                    <Parameter id="XTxgrEMitEelHNtHJbkRsQ" name="Vf (intracellular water)-RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.456">
                       <ValueOrigin id="22" source="Publication" description="Rodgers T, Rowland M. Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J Pharm Sci. 2006 Jun;95(6):1238-57 https://doi.org/10.1002/jps.20502" />
                       <Info min="0" max="1" flag="122" seq="558" ref="0" bb="32" group="92" />
                     </Parameter>
-                    <Parameter id="KAmsmDg0qkOX5iRPkvNBmA" name="Vf (water)-WS" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.78">
+                    <Parameter id="DAgxRpPyMkS7EvLqUYUYbQ" name="Vf (water)-WS" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.78">
                       <Info min="0" max="1" flag="122" seq="558" ref="0" bb="32" group="95" />
                     </Parameter>
-                    <Parameter id="4lorz7Es8UihqeBG70Rbaw" name="Vf (acidic phospholipids)-WS" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0035">
-                      <Info min="0" max="1" flag="122" seq="559" ref="0" bb="32" group="95" />
-                    </Parameter>
-                    <Parameter id="7A4Ked98bkGRJT4LzQlGog" name="Acidic phospholipids [mg/g] - RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.41">
+                    <Parameter id="gMaHUed7gUGjphQTIaVvZQ" name="Acidic phospholipids [mg/g] - RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.41">
                       <ValueOrigin id="21" source="Publication" description="Rodgers T, Leahy D, Rowland M. Physiologically based pharmacokinetic modeling 1: predicting the tissue distribution of moderate-to-strong bases. J Pharm Sci. 2005 Jun;94(6):1259-76. https://doi.org/10.1002/jps.20322" />
                       <Info min="0" max="1000" flag="122" seq="559" ref="0" bb="32" group="92" />
                     </Parameter>
-                    <Container id="OKXf1Dl7Jk-2HzmG8_06yw" name="Plasma" mode="Physical" containerType="Compartment">
+                    <Parameter id="MPvqDKS7u02T_5yhRMOTbw" name="Vf (acidic phospholipids)-WS" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0035">
+                      <Info min="0" max="1" flag="122" seq="559" ref="0" bb="32" group="95" />
+                    </Parameter>
+                    <Container id="0kFKBI9cUEeUTIqKlJNFrg" name="Plasma" mode="Physical" containerType="Compartment">
                       <Tags>
                         <Tag value="Duodenum" />
                         <Tag value="Mucosa" />
                         <Tag value="SmallIntestineSegment" />
                       </Tags>
                       <Children>
-                        <Parameter id="WHtX7Ya3yUSObMeIIBKRRQ" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
-                          <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
-                        </Parameter>
-                        <Parameter id="dY2Xcf9AEkeRZMrWv6Zt9Q" name="FcRn concentration in container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.FcRn_in_Container_Plasma" isDefault="1" displayUnit="µmol/l">
+                        <Parameter id="pdL9rP40h0SmVFqQmip2UQ" name="FcRn concentration in container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.FcRn_in_Container_Plasma" isDefault="1" displayUnit="µmol/l">
                           <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                           <Info flag="52" seq="1" ref="0" bb="2" group="25" />
                         </Parameter>
-                        <Parameter id="NzNQODwoEEWrKpwvZphPrg" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_pls_2Pores" isDefault="1" displayUnit="l">
+                        <Parameter id="ImkhYlZZuE6WJv2bpzLVJQ" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                          <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                        </Parameter>
+                        <Parameter id="bfwZj83ivkaWWsOUWKILWg" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_pls_2Pores" isDefault="1" displayUnit="l">
                           <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                           <Info min="0" flag="62" seq="111" ref="0" bb="2" group="126" />
                         </Parameter>
-                        <Container id="JvJyY8BJNkWvfQvrLmXAYw" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                        <Container id="-toYReMHR06_752QcTdhew" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                           <Children>
-                            <Parameter id="sVQSYRfD9E-j7nZhdvYi8g" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Plasma_and_Interstitial" isDefault="1" displayUnit="µmol/l">
+                            <Parameter id="hJ3lBMoxVE-YJdDP89a1wA" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Plasma_and_Interstitial" isDefault="1" displayUnit="µmol/l">
                               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                               <Info flag="52" seq="1" ref="0" bb="2" group="25" />
                             </Parameter>
-                            <Parameter id="qAEbtGUT0E6dCBaz1a6gKA" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                            <Parameter id="YD5PZNHNx0ytrjcVP46adQ" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                             </Parameter>
-                            <Parameter id="ho7Dgj59tkS4ok-GBi2IXg" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" isDefault="1">
+                            <Parameter id="GHGU2GYsskCAGuAdtl-a8g" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                             </Parameter>
-                            <Parameter id="8Pd84QSV7kKuTBiEMv8IsQ" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                            <Parameter id="sKEavxwVE0a2VbIeN81ebQ" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
                               <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                             </Parameter>
                           </Children>
                         </Container>
                       </Children>
                     </Container>
-                    <Container id="saXE0Q67yUSDrhlQv5I4-A" name="BloodCells" mode="Physical" containerType="Compartment">
+                    <Container id="2WfG5NZzVUWJFhsQUD4L5w" name="BloodCells" mode="Physical" containerType="Compartment">
                       <Tags>
                         <Tag value="Duodenum" />
                         <Tag value="Mucosa" />
                         <Tag value="SmallIntestineSegment" />
                       </Tags>
                       <Children>
-                        <Parameter id="DrY41krjtkGWYxahYjMidg" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                        <Parameter id="IDLcXvHelk2lNv5ZNiqWNQ" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
                           <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                         </Parameter>
-                        <Parameter id="Njtia3exAUa5gRYpPeCVXg" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_bc_2Pores" isDefault="1" displayUnit="l">
+                        <Parameter id="L2AZKLfp60qF1VyIVzKqTw" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_bc_2Pores" isDefault="1" displayUnit="l">
                           <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                           <Info min="0" flag="62" seq="111" ref="0" bb="2" group="121" />
                         </Parameter>
-                        <Container id="eZ-H4450q0GXQrcuQsNJqQ" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                        <Container id="_Q-OySQbd0WmZdbb8xJ1Cw" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                           <Children>
-                            <Parameter id="Ctd5NItk-ka_ItnXxwwf3A" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
-                              <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
-                            </Parameter>
-                            <Parameter id="5IO7glRlqUafkqJhBrGgyg" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                            <Parameter id="JYIj2qWr3E-YPuUlwMVAOQ" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                             </Parameter>
-                            <Parameter id="YO4x--bLs0-UccexA0AR3Q" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" isDefault="1">
+                            <Parameter id="cq_fCj2KTkaajtqNa6fs5Q" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                             </Parameter>
+                            <Parameter id="SaglksBlykGpiEqlu3zfrQ" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                              <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                            </Parameter>
                           </Children>
                         </Container>
                       </Children>
                     </Container>
-                    <Container id="PmvtstzTK0a-1-Q0VCujAw" name="Interstitial" mode="Physical" containerType="Compartment">
+                    <Container id="9R0Unr1G1UOVIkd4QMmImA" name="Interstitial" mode="Physical" containerType="Compartment">
                       <Tags>
                         <Tag value="Duodenum" />
                         <Tag value="Mucosa" />
                         <Tag value="SmallIntestineSegment" />
                       </Tags>
                       <Children>
-                        <Parameter id="pU4XRl3RV0Sk8Os2mAliog" name="FcRn concentration in container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.FcRn_in_Container_Interstitial" isDefault="1" displayUnit="µmol/l">
+                        <Parameter id="V-H-avRpvUS4uZNVzG2EYw" name="FcRn concentration in container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.FcRn_in_Container_Interstitial" isDefault="1" displayUnit="µmol/l">
                           <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                           <Info flag="52" seq="1" ref="0" bb="2" group="25" />
                         </Parameter>
-                        <Parameter id="_vAXF_nNo0WtMTQwhziQ-Q" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                        <Parameter id="FKZwlOum50m60IpIYUSkAg" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
                           <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                         </Parameter>
-                        <Parameter id="_5T65EUcSEuzZqG69bI9aA" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_int_2Pores" isDefault="1" displayUnit="l">
+                        <Parameter id="QHLucr6fe06xGII4EURI8Q" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_int_2Pores" isDefault="1" displayUnit="l">
                           <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                           <Info min="0" flag="62" seq="111" ref="0" bb="2" group="124" />
                         </Parameter>
-                        <Parameter id="OKV7Un3P7E2ZUKgci0HF3Q" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_pH_INT" isDefault="1">
+                        <Parameter id="sEDfihsHmEG7fc8nYTAPVA" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_pH_INT" isDefault="1">
                           <Tags>
                             <Tag value="Duodenum" />
                             <Tag value="Mucosa" />
@@ -8027,26 +8084,26 @@
                           </Tags>
                           <Info min="0" max="14" flag="122" seq="335" ref="0" bb="32" group="84" />
                         </Parameter>
-                        <Container id="NVuMjE6MCkmJrdxoMm38mw" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                        <Container id="aWZVF-lPQkW4L_NWErtY6w" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                           <Children>
-                            <Parameter id="px07rd2PPkOmoXNekQu0Dg" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Plasma_and_Interstitial" isDefault="1" displayUnit="µmol/l">
+                            <Parameter id="xPPsV_xp_Euh5l39uKh0Bg" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Plasma_and_Interstitial" isDefault="1" displayUnit="µmol/l">
                               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                               <Info flag="52" seq="1" ref="0" bb="2" group="25" />
                             </Parameter>
-                            <Parameter id="SzGvzOXZS0-Xe1La16lZbQ" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                            <Parameter id="wU52u1jsWUSqCtYs-hJm1g" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                             </Parameter>
-                            <Parameter id="NeO0L717P0ylVfF5JvEPPg" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_duo" isDefault="1">
+                            <Parameter id="eoyKeqejq0-krC0wJT3iFg" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_duo" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                             </Parameter>
-                            <Parameter id="pm65cxj5rUSzdyjlk761XA" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                            <Parameter id="Nw5L6uUZ00yObW7RasLRBA" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
                               <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                             </Parameter>
                           </Children>
                         </Container>
                       </Children>
                     </Container>
-                    <Container id="n53695myoESMtqbFy_q0Ww" name="Intracellular" mode="Physical" containerType="Compartment">
+                    <Container id="gWunQQ0CDk63u-YyP8U4Tw" name="Intracellular" mode="Physical" containerType="Compartment">
                       <Tags>
                         <Tag value="Duodenum" />
                         <Tag value="IntestinalSecretionSource" />
@@ -8054,14 +8111,14 @@
                         <Tag value="SmallIntestineSegment" />
                       </Tags>
                       <Children>
-                        <Parameter id="RI8HYNsp9E61Alipo53Ykg" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" isDefault="1" displayUnit="l">
+                        <Parameter id="cS5fZRXo_UC4CgT5aIxbsA" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" isDefault="1" displayUnit="l">
                           <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                         </Parameter>
-                        <Parameter id="HDc4bhVJKU6rXSOgeAUS4w" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_cell_2Pores" isDefault="1" displayUnit="l">
+                        <Parameter id="j4Y9OhUwiUmaF4GmzuTUJQ" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_cell_2Pores" isDefault="1" displayUnit="l">
                           <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                           <Info min="0" flag="62" seq="111" ref="0" bb="2" group="125" />
                         </Parameter>
-                        <Parameter id="gzks93PfjkOLULEOPxQ5XA" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.3">
+                        <Parameter id="jlVToBX9z0CEXeYVTBwvMQ" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.3">
                           <Tags>
                             <Tag value="Duodenum" />
                             <Tag value="IntestinalSecretionSource" />
@@ -8071,296 +8128,296 @@
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+                        <Container id="xboi4g7nr0mP1Fg5xmdB8w" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                           <Children>
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+                            <Parameter id="Dg6T_VxW-UOqXC-s333p-A" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                              <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                            </Parameter>
+                            <Parameter id="uqxiNB1u-EypqkBiHSSkzw" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_duo" isDefault="1">
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+                            <Parameter id="YOnkDRZcR06eG4ndDs_KXQ" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
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                         </Container>
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-                    <Container id="tojqVwAWfEuycwJB_JsrGQ" name="Endosome" mode="Physical" containerType="Compartment">
+                    <Container id="1hJKls6_H02uJRPrES2dVA" name="Endosome" mode="Physical" containerType="Compartment">
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                         <Tag value="Duodenum" />
                         <Tag value="Mucosa" />
                         <Tag value="SmallIntestineSegment" />
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+                        <Parameter id="uVTkSpmhz0KKdGuKJj8qDg" name="FcRn concentration in container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.FcRn_in_Container_Endosomal" isDefault="1" displayUnit="µmol/l">
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+                        <Parameter id="4dynnBw6PUqq_3Swfo7_xg" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
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+                        <Parameter id="N5S5ZfVxAk6KA3CvVOMMjw" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_end_duo" isDefault="1" displayUnit="l">
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                         </Parameter>
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+                        <Container id="HkjfXM84WUK7cY_XqIU03w" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                           <Children>
-                            <Parameter id="4WPubfA4ek6-v1ZpYDzhlA" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Endosomal" isDefault="1" displayUnit="µmol/l">
+                            <Parameter id="VNeCr9EefU-0PUfeHhs62Q" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Endosomal" isDefault="1" displayUnit="µmol/l">
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+                            <Parameter id="vf5pa2U4a0aBkSS-FNwSKA" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
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+                            <Parameter id="AndrukamqU25mRpQiN8ixA" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
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+                    <Parameter id="GujSX7khCkmLK9X7HWvoNg" name="Volume (endothelium)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="VascularEndoVolume.VOLUME_VascularEndo_uje" isDefault="1" displayUnit="l">
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+                        <Parameter id="JV9sxtXm8Ea4Pkd0b51Igw" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
                           <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                         </Parameter>
-                        <Parameter id="L5rNXfmJD0GsG90_d6MC1w" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_bc_2Pores" isDefault="1" displayUnit="l">
+                        <Parameter id="tyjeCBSjG0u3ixx6mwXuxg" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_bc_2Pores" isDefault="1" displayUnit="l">
                           <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                           <Info min="0" flag="62" seq="112" ref="0" bb="2" group="121" />
                         </Parameter>
-                        <Container id="tIEETF0v9UyBD1jo97WhbA" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                        <Container id="jztLIwJGREifnCcm9WeaPQ" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                           <Children>
-                            <Parameter id="3hAAmxa3E0C_qoeAUs4N8w" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                            <Parameter id="P3Q-0o6B7EmNSv1x0jxsWQ" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                             </Parameter>
-                            <Parameter id="_6aUlcQJqU-U5WK_7rxvBA" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" isDefault="1">
+                            <Parameter id="Fov-rYYWokKu0MYk2qoE9w" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                             </Parameter>
-                            <Parameter id="WZ0zHraqPk-LA87twDXriA" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                            <Parameter id="lZM28MOsPEGTBlZ6-pFpzQ" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
                               <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                             </Parameter>
                           </Children>
                         </Container>
                       </Children>
                     </Container>
-                    <Container id="m9r4GvDTzUuI9_2hwpc2GA" name="Interstitial" mode="Physical" containerType="Compartment">
+                    <Container id="YxtZTHDCL06WvjrJPu6N3g" name="Interstitial" mode="Physical" containerType="Compartment">
                       <Tags>
                         <Tag value="Mucosa" />
                         <Tag value="SmallIntestineSegment" />
                         <Tag value="UpperJejunum" />
                       </Tags>
                       <Children>
-                        <Parameter id="oyBc8yYwokOyHOkx84T0CQ" name="FcRn concentration in container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.FcRn_in_Container_Interstitial" isDefault="1" displayUnit="µmol/l">
+                        <Parameter id="fMFmmc8jQUWLUdo8PdlzAw" name="FcRn concentration in container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.FcRn_in_Container_Interstitial" isDefault="1" displayUnit="µmol/l">
                           <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                           <Info flag="52" seq="1" ref="0" bb="2" group="25" />
                         </Parameter>
-                        <Parameter id="i3H9mKcMXEySRYyfwFFfhg" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                        <Parameter id="87V_BqIHAUqDGuaIrWS9rw" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
                           <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                         </Parameter>
-                        <Parameter id="dPMm2CZqFUyJlUTM1vHXZQ" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_int_2Pores" isDefault="1" displayUnit="l">
+                        <Parameter id="79YgevhgqUSO2_GS4QT8YQ" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_int_2Pores" isDefault="1" displayUnit="l">
                           <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                           <Info min="0" flag="62" seq="112" ref="0" bb="2" group="124" />
                         </Parameter>
-                        <Parameter id="J9AMZO-MjkqBZXMXRRwaOg" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_pH_INT" isDefault="1">
+                        <Parameter id="JzfgfiVUdEihX9Qr4V4Gyg" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_pH_INT" isDefault="1">
                           <Tags>
                             <Tag value="Mucosa" />
                             <Tag value="SmallIntestineSegment" />
@@ -8368,26 +8425,26 @@
                           </Tags>
                           <Info min="0" max="14" flag="122" seq="338" ref="0" bb="32" group="84" />
                         </Parameter>
-                        <Container id="ADzKk-whv0iiCuy59-s-RQ" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                        <Container id="XCBNA9Frk0K8V2KQxIbC0w" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                           <Children>
-                            <Parameter id="SSmit3cS6kOaYJ3RLhNVXg" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Plasma_and_Interstitial" isDefault="1" displayUnit="µmol/l">
+                            <Parameter id="igfQQ3V2Wk-8u4Is96pFjQ" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Plasma_and_Interstitial" isDefault="1" displayUnit="µmol/l">
                               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                               <Info flag="52" seq="1" ref="0" bb="2" group="25" />
                             </Parameter>
-                            <Parameter id="mVRkQlrbsUSdritxucx3Jw" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                            <Parameter id="k5IrdZAc1k-uCU0fF-wB5A" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                             </Parameter>
-                            <Parameter id="nrNRg-4fKk6Rzo0cQG8fjQ" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_uje" isDefault="1">
+                            <Parameter id="HJv5ICU9ZEGdQDgl1_DEBw" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_uje" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                             </Parameter>
-                            <Parameter id="m03Q_LR78Uu5lSKaxeBP1g" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                            <Parameter id="CarYZgAZFkKWP1-OYJmAYg" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
                               <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                             </Parameter>
                           </Children>
                         </Container>
                       </Children>
                     </Container>
-                    <Container id="Gl4u9SB4D0S0tsiS1WYoSw" name="Intracellular" mode="Physical" containerType="Compartment">
+                    <Container id="f9JNWIahuU-I4czMeCoORQ" name="Intracellular" mode="Physical" containerType="Compartment">
                       <Tags>
                         <Tag value="IntestinalSecretionSource" />
                         <Tag value="Mucosa" />
@@ -8395,14 +8452,14 @@
                         <Tag value="UpperJejunum" />
                       </Tags>
                       <Children>
-                        <Parameter id="HtGttS82X0OdJBE-R1suGw" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" isDefault="1" displayUnit="l">
+                        <Parameter id="fYoWI9Cs3kyrLVtd5s880Q" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" isDefault="1" displayUnit="l">
                           <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                         </Parameter>
-                        <Parameter id="ByYaGaIicU-7ECnHSqPzyg" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_cell_2Pores" isDefault="1" displayUnit="l">
+                        <Parameter id="8QM_bUBJSEemNLaAFAnIFA" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_cell_2Pores" isDefault="1" displayUnit="l">
                           <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                           <Info min="0" flag="62" seq="112" ref="0" bb="2" group="125" />
                         </Parameter>
-                        <Parameter id="yJeaCun5OUerpxVr82WHig" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.3">
+                        <Parameter id="43l5P9pvwUOsW0LSnvEOKw" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.3">
                           <Tags>
                             <Tag value="IntestinalSecretionSource" />
                             <Tag value="Mucosa" />
@@ -8412,296 +8469,296 @@
                           <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
                           <Info min="0" max="14" flag="122" seq="338" ref="0" bb="32" group="83" />
                         </Parameter>
-                        <Container id="6q7Sf7GWQEeakxbWkYoWMQ" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                        <Container id="ATm2ejhbjEuEGmAEo3y0kw" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                           <Children>
-                            <Parameter id="IOEnflXQo0CaylC_cNMOnA" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                            <Parameter id="WsgIdppZgUq4DZHq7QuhLg" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                             </Parameter>
-                            <Parameter id="GXM993Q-VkiYoNkwEIXczQ" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_uje" isDefault="1">
+                            <Parameter id="eCc6-bGEiUy7u-haJsqf7w" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_uje" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                             </Parameter>
-                            <Parameter id="TsrasjdPXEqshhQ10r0qXg" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                            <Parameter id="e4Pbe1hgY0S8VJeyfBZHIQ" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
                               <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                             </Parameter>
                           </Children>
                         </Container>
                       </Children>
                     </Container>
-                    <Container id="6baqNVJRp0-ySQVJaozYtA" name="Endosome" mode="Physical" containerType="Compartment">
+                    <Container id="qBzxt-UQmUmrfuDgbrmGVA" name="Endosome" mode="Physical" containerType="Compartment">
                       <Tags>
                         <Tag value="Mucosa" />
                         <Tag value="SmallIntestineSegment" />
                         <Tag value="UpperJejunum" />
                       </Tags>
                       <Children>
-                        <Parameter id="-l3ci1ObfUudRWdAvdyPyA" name="FcRn concentration in container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.FcRn_in_Container_Endosomal" isDefault="1" displayUnit="µmol/l">
+                        <Parameter id="4OuHVVmR-UChUU68M-VnCQ" name="FcRn concentration in container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.FcRn_in_Container_Endosomal" isDefault="1" displayUnit="µmol/l">
                           <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                           <Info flag="52" seq="1" ref="0" bb="2" group="25" />
                         </Parameter>
-                        <Parameter id="r-oGs1xoXEmfHLEyR7rm4g" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                        <Parameter id="MSJN6JkqxEmBIFTXhgh5Wg" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
                           <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                         </Parameter>
-                        <Parameter id="diuIdTY2GU2QAisEp5O3aw" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_end_uje" isDefault="1" displayUnit="l">
+                        <Parameter id="rBUshnMc3Uu1Pbelefxk9w" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_end_uje" isDefault="1" displayUnit="l">
                           <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                           <Info min="0" flag="122" seq="112" ref="0" bb="2" group="123" />
                         </Parameter>
-                        <Container id="jfTzqR5dtEm8nPUWDN4lIA" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                        <Container id="CK-uG-ImhUGaYVTRnocSjQ" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                           <Children>
-                            <Parameter id="BR-KZRvXAkKrVGfc4P3RVw" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                            <Parameter id="47eQj9JNqUGA3t-3R7e0sg" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Endosomal" isDefault="1" displayUnit="µmol/l">
                               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-                              <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                              <Info flag="52" seq="1" ref="0" bb="2" group="25" />
                             </Parameter>
-                            <Parameter id="gRLj9hCJLUis9EcgUEZGlA" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                            <Parameter id="0svDA2jYI0OwDrZ7LgNhLA" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                             </Parameter>
-                            <Parameter id="wvxEvD4yYESPQt-7cehz2w" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
-                              <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
-                            </Parameter>
-                            <Parameter id="YVTCELC84EapKHU3uLrQFw" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Endosomal" isDefault="1" displayUnit="µmol/l">
+                            <Parameter id="MFC-ybQiQEil3Nn2PoK7iw" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
                               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-                              <Info flag="52" seq="1" ref="0" bb="2" group="25" />
+                              <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                            </Parameter>
+                            <Parameter id="LKD384Ve10C0DzovOyQCGA" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                              <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                             </Parameter>
                           </Children>
                         </Container>
                       </Children>
                     </Container>
-                    <Container id="-ujrz16yrk298N9BLW1hTw" name="MoleculeProperties" mode="Logical" containerType="Molecule" />
+                    <Container id="JWU_eDYN60uYzTb7DkQDhw" name="MoleculeProperties" mode="Logical" containerType="Molecule" />
                   </Children>
                 </Container>
-                <Container id="GRaUhBnk6UOOrQkH5O60xg" name="LowerJejunum" mode="Logical" containerType="Compartment">
+                <Container id="rVWJvClULEqXhWswKe4yuQ" name="LowerJejunum" mode="Logical" containerType="Compartment">
                   <Children>
-                    <Parameter id="MDim7alkDE62nK3vqMEU2A" name="Fraction of endosomal uptake from plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_uptake_vas" isDefault="1">
+                    <Parameter id="KfREvdyimUCT-ixcWpFBeg" name="Fraction of endosomal uptake from plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_uptake_vas" isDefault="1">
                       <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                       <Info min="0" flag="54" seq="0" ref="0" bb="2" group="25" />
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+                    <Parameter id="c4ieawp8ckWwIGzJxoRjQA" name="Vf (water)-WS" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.78">
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+                    <Parameter id="hTJQm3kdq0iqWGfSS5dfmQ" name="Acidic phospholipids [mg/g] - RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.41">
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+                    <Parameter id="vq8nXl5CKUSBExXngVDjFQ" name="Vf (acidic phospholipids)-WS" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0035">
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                     </Parameter>
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                         <Tag value="LowerJejunum" />
                         <Tag value="Mucosa" />
                         <Tag value="SmallIntestineSegment" />
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+                        <Parameter id="WmRm27lsGE-9AOvuCfJY1w" name="FcRn concentration in container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.FcRn_in_Container_Plasma" isDefault="1" displayUnit="µmol/l">
                           <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                           <Info flag="52" seq="1" ref="0" bb="2" group="25" />
                         </Parameter>
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+                        <Parameter id="Ra2BTX2AdEmeithkWpF3vw" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
                           <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                         </Parameter>
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+                        <Parameter id="zX3vGQpkqUSIv3QZL5udFA" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_pls_2Pores" isDefault="1" displayUnit="l">
                           <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                           <Info min="0" flag="62" seq="113" ref="0" bb="2" group="126" />
                         </Parameter>
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+                        <Container id="rrg88BVg6ku4jabVvQjB6g" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                           <Children>
-                            <Parameter id="J7FDpWatOEGUx4YQl8t5Gw" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Plasma_and_Interstitial" isDefault="1" displayUnit="µmol/l">
+                            <Parameter id="SSogoSNhiUWtMawrbh7AaA" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Plasma_and_Interstitial" isDefault="1" displayUnit="µmol/l">
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                               <Info flag="52" seq="1" ref="0" bb="2" group="25" />
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+                            <Parameter id="E1LKuOeGnki0zjLU4-IQsg" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                             </Parameter>
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+                            <Parameter id="mL4a0lIPiEGVlEoCEF7IPQ" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                             </Parameter>
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+                            <Parameter id="pZKMgttz7EuTsrJrtO2q1g" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
                               <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
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                       <Tags>
                         <Tag value="LowerJejunum" />
                         <Tag value="Mucosa" />
                         <Tag value="SmallIntestineSegment" />
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                           <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
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+                        <Parameter id="bIQOlMFhfUebR2Gg9Qj7aQ" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_bc_2Pores" isDefault="1" displayUnit="l">
                           <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                           <Info min="0" flag="62" seq="113" ref="0" bb="2" group="121" />
                         </Parameter>
-                        <Container id="HFMzqMiBf0OJmHO2EQi7ow" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                        <Container id="8ni91PGNRUObi3RsHYwe_Q" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                           <Children>
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+                            <Parameter id="MSNXvzeGo0Wt3QakjGUVsg" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
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+                            <Parameter id="C3W7_9lTIU2UZnDEG7hNMg" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                             </Parameter>
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+                            <Parameter id="5oj5mqckvUmG-zKf2AdKWw" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
                               <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
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-                    <Container id="hWIJNL39KEqDcHwJ2WVNAQ" name="Interstitial" mode="Physical" containerType="Compartment">
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                       <Tags>
                         <Tag value="LowerJejunum" />
                         <Tag value="Mucosa" />
                         <Tag value="SmallIntestineSegment" />
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+                        <Parameter id="50jpWBcZy0CpzDaUjLkelw" name="FcRn concentration in container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.FcRn_in_Container_Interstitial" isDefault="1" displayUnit="µmol/l">
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                           <Info flag="52" seq="1" ref="0" bb="2" group="25" />
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+                        <Parameter id="0TxtyTACW0-x2sISUbQrUQ" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                          <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                        </Parameter>
+                        <Parameter id="bwcMwlMT5UqvOykjjsY_1Q" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_int_2Pores" isDefault="1" displayUnit="l">
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                           <Info min="0" flag="62" seq="113" ref="0" bb="2" group="124" />
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-                        <Parameter id="K-F67xQEPkqAX896dHtifg" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_pH_INT" isDefault="1">
+                        <Parameter id="1iEI1RNjDkS1qnRWSrhM4A" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_pH_INT" isDefault="1">
                           <Tags>
                             <Tag value="LowerJejunum" />
                             <Tag value="Mucosa" />
@@ -8709,26 +8766,26 @@
                           </Tags>
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                         </Parameter>
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+                            <Parameter id="9CKd5oWqYEa0f3rMpPt0DQ" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Plasma_and_Interstitial" isDefault="1" displayUnit="µmol/l">
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                               <Info flag="52" seq="1" ref="0" bb="2" group="25" />
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+                            <Parameter id="YZh-03A80EiSfYXaGAz-ng" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
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+                            <Parameter id="4U0Wvt5AF0OutF9areVDXQ" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_lje" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                             </Parameter>
-                            <Parameter id="O0m7zGm4OEWIDrJLWNtnrA" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                            <Parameter id="fTT2cUIwvka9uq4Ma7RABA" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
                               <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                             </Parameter>
                           </Children>
                         </Container>
                       </Children>
                     </Container>
-                    <Container id="BC5XIDg8L0Kh6isr8xLJnw" name="Intracellular" mode="Physical" containerType="Compartment">
+                    <Container id="vbzZRD1fTUGB9xYY7QdQcA" name="Intracellular" mode="Physical" containerType="Compartment">
                       <Tags>
                         <Tag value="IntestinalSecretionSource" />
                         <Tag value="LowerJejunum" />
@@ -8736,14 +8793,14 @@
                         <Tag value="SmallIntestineSegment" />
                       </Tags>
                       <Children>
-                        <Parameter id="GhJLW5U9rECnbLtEmFqB5g" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" isDefault="1" displayUnit="l">
+                        <Parameter id="wMbG3qkDckOvNthOTVFOBw" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" isDefault="1" displayUnit="l">
                           <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                         </Parameter>
-                        <Parameter id="HBlt99fZr0uGIbTfJZx2QA" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_cell_2Pores" isDefault="1" displayUnit="l">
+                        <Parameter id="3wb0aP13WUSuLZmiSEW8Kw" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_cell_2Pores" isDefault="1" displayUnit="l">
                           <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                           <Info min="0" flag="62" seq="113" ref="0" bb="2" group="125" />
                         </Parameter>
-                        <Parameter id="6-1mFvge1U2jUhs9xOHYaA" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.3">
+                        <Parameter id="AF4aX1etXk2AUDG_vJ4Lew" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.3">
                           <Tags>
                             <Tag value="IntestinalSecretionSource" />
                             <Tag value="LowerJejunum" />
@@ -8753,296 +8810,296 @@
                           <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
                           <Info min="0" max="14" flag="122" seq="341" ref="0" bb="32" group="83" />
                         </Parameter>
-                        <Container id="A1iNitA_tUGHt2FrT3iIuA" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                        <Container id="dyq_SMRoy0KY3n6ZLnbtog" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                           <Children>
-                            <Parameter id="5gTKtMRXXkSfleVwzu0eQQ" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                            <Parameter id="UpApbGbhiE2XV1V4JZUAEw" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                             </Parameter>
-                            <Parameter id="IcI_Df6tj0e8SX526NEGJA" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_lje" isDefault="1">
+                            <Parameter id="KJWwc1-ftEKKF1YcwctTXw" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_lje" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                             </Parameter>
-                            <Parameter id="jxT50_fi5ka85vke2VOu-A" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                            <Parameter id="9kDjy0qEPEqh4_kuOhx5Zg" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
                               <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                             </Parameter>
                           </Children>
                         </Container>
                       </Children>
                     </Container>
-                    <Container id="rIaw61dxMkWQYOa1GJJmKA" name="Endosome" mode="Physical" containerType="Compartment">
+                    <Container id="nGmORWNShk6c7ck4uoKR9g" name="Endosome" mode="Physical" containerType="Compartment">
                       <Tags>
                         <Tag value="LowerJejunum" />
                         <Tag value="Mucosa" />
                         <Tag value="SmallIntestineSegment" />
                       </Tags>
                       <Children>
-                        <Parameter id="PVx4cPjfnk-ntZhqQfjovw" name="FcRn concentration in container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.FcRn_in_Container_Endosomal" isDefault="1" displayUnit="µmol/l">
+                        <Parameter id="OPD-a35C00OzVpuwkgma7g" name="FcRn concentration in container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.FcRn_in_Container_Endosomal" isDefault="1" displayUnit="µmol/l">
                           <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                           <Info flag="52" seq="1" ref="0" bb="2" group="25" />
                         </Parameter>
-                        <Parameter id="Eov3TNWSQkS9FqzRwrrjkQ" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                        <Parameter id="LM9iuFyv302vHBQCVoyQnw" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
                           <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                         </Parameter>
-                        <Parameter id="N4aDCIBrZ0qkZ_HOpF8Rpw" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_end_lje" isDefault="1" displayUnit="l">
+                        <Parameter id="B2RK5-UbZ0aar2bLJNaD_g" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_end_lje" isDefault="1" displayUnit="l">
                           <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                           <Info min="0" flag="122" seq="113" ref="0" bb="2" group="123" />
                         </Parameter>
-                        <Container id="zhp3iFfRVkefgD2kLuSZRg" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                        <Container id="jbQx1sB4ckeg0pQziZm7Gw" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                           <Children>
-                            <Parameter id="E8mN_bcgKU6LzGIlvqioFw" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Endosomal" isDefault="1" displayUnit="µmol/l">
+                            <Parameter id="s1kENwA9C0yzog9O0NyZnA" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Endosomal" isDefault="1" displayUnit="µmol/l">
                               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                               <Info flag="52" seq="1" ref="0" bb="2" group="25" />
                             </Parameter>
-                            <Parameter id="Kwy1vQ0fKk2-hnNnAjL7tg" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                            <Parameter id="dEFBvAhCWkSEdosgaqpkcg" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                             </Parameter>
-                            <Parameter id="dmMKA6nWbEGprbM15tkhBg" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                            <Parameter id="INr-luRO3kucAosOcunxsw" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
                               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                             </Parameter>
-                            <Parameter id="FycF2G_zh0u4FF5ia3i1cA" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                            <Parameter id="hvfL8pzSFkWAggyLESTeZQ" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
                               <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                             </Parameter>
                           </Children>
                         </Container>
                       </Children>
                     </Container>
-                    <Container id="9L1aHIfeu0uq1OvcbrTTZA" name="MoleculeProperties" mode="Logical" containerType="Molecule" />
+                    <Container id="NL7_V78zZk2y8LgObuzUNg" name="MoleculeProperties" mode="Logical" containerType="Molecule" />
                   </Children>
                 </Container>
-                <Container id="vhgiXjg6xkOniu0vP0xCxw" name="UpperIleum" mode="Logical" containerType="Compartment">
+                <Container id="xzl5keK3zEWD9eH-CbKpAA" name="UpperIleum" mode="Logical" containerType="Compartment">
                   <Children>
-                    <Parameter id="znWU-cAArki9hUz5hYjHLQ" name="Fraction of endosomal uptake from plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_uptake_vas" isDefault="1">
+                    <Parameter id="gNodeswyQkWTWZfhYqTh1w" name="Fraction of endosomal uptake from plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_uptake_vas" isDefault="1">
                       <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                       <Info min="0" flag="54" seq="0" ref="0" bb="2" group="25" />
                     </Parameter>
-                    <Parameter id="T98KlnQ7EEWtnLAhji9Hyg" name="Fraction recycled to plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_rec_vas" isDefault="1">
+                    <Parameter id="N9XFFqWQHkClJ0IDNP_fFA" name="Fraction endosomal" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_endo" isDefault="1">
+                      <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                      <Info min="0" max="1" flag="54" seq="1" ref="0" bb="2" group="29" />
+                    </Parameter>
+                    <Parameter id="500uEwnJGUWjB6q1976MDA" name="Fraction recycled to plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_rec_vas" isDefault="1">
                       <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                       <Info min="0" flag="54" seq="1" ref="0" bb="2" group="25" />
                     </Parameter>
-                    <Parameter id="iMjAcIrVlEyikUiq_6NUDA" name="Rate constant for endosomal uptake" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_K_uptake" isDefault="1" displayUnit="1/min">
+                    <Parameter id="iToWtFL4E0SURAVuvQEmJQ" name="Rate constant for endosomal uptake" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_K_uptake" isDefault="1" displayUnit="1/min">
                       <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                       <Info min="0" flag="54" seq="1" ref="0" bb="2" group="25" />
                     </Parameter>
-                    <Parameter id="CpvTn_GsrkGTk3P1iUodWA" name="Rate constant for recycling from endosomal space" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_K_rec" isDefault="1" displayUnit="1/min">
+                    <Parameter id="77QLS-7qI0WWQOPBWZhQ2A" name="Rate constant for recycling from endosomal space" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_K_rec" isDefault="1" displayUnit="1/min">
                       <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                       <Info min="0" flag="54" seq="1" ref="0" bb="2" group="25" />
                     </Parameter>
-                    <Parameter id="zx0mvsHFuUaVKeOBnOACFw" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
+                    <Parameter id="sKIc2aHNHUG2EAWEejbtnw" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
                       <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
                     </Parameter>
-                    <Parameter id="TbqLfnPpN0imHlYnTRi17Q" name="Fraction endosomal" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_endo" isDefault="1">
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-                      <Info min="0" max="1" flag="54" seq="1" ref="0" bb="2" group="29" />
-                    </Parameter>
-                    <Parameter id="IbPBkQrKIUK02RS9XvuIIA" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="MucosaVolume.VOLUME_MucosaUpperIleum" isDefault="1" displayUnit="l">
+                    <Parameter id="UlQHx15RJkC2TpTz5qEHBw" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="MucosaVolume.VOLUME_MucosaUpperIleum" isDefault="1" displayUnit="l">
                       <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
                       <Info min="0" flag="122" seq="23" ref="0" bb="32" group="65" />
                     </Parameter>
-                    <Parameter id="cG4U4mVFIUmjZaS5K7Fy0A" name="Volume (endothelium)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="VascularEndoVolume.VOLUME_VascularEndo_uil" isDefault="1" displayUnit="l">
-                      <Info min="0" flag="62" seq="114" ref="0" bb="32" group="127" />
-                    </Parameter>
-                    <Parameter id="8rYd6OEJzU-igxr1rVVQBQ" name="Fluid recirculation flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_J_iso_Mucosa" isDefault="1" displayUnit="l/min">
+                    <Parameter id="3F_QR6qDi0ylXRchbYkNAA" name="Fluid recirculation flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_J_iso_Mucosa" isDefault="1" displayUnit="l/min">
                       <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                       <Info min="0" flag="122" seq="114" ref="0" bb="32" group="27" />
                     </Parameter>
-                    <Parameter id="pj88p5ABikK70AgInIOv6w" name="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_lymph_mucosa" isDefault="1" displayUnit="l/min">
+                    <Parameter id="oeawo_b0vk-tT-pMIAT4PQ" name="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_lymph_mucosa" isDefault="1" displayUnit="l/min">
                       <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                       <Info min="0" flag="122" seq="114" ref="0" bb="32" group="58" />
                     </Parameter>
-                    <Parameter id="t5N4clhtL02r7dWo_NzNeQ" name="Blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_mucosa" isDefault="1" displayUnit="l/min">
+                    <Parameter id="L_FIJ9kJZ0i-jraJ89pKxQ" name="Volume (endothelium)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="VascularEndoVolume.VOLUME_VascularEndo_uil" isDefault="1" displayUnit="l">
+                      <Info min="0" flag="62" seq="114" ref="0" bb="32" group="127" />
+                    </Parameter>
+                    <Parameter id="uWGIYgCDnU27GT38ncatzw" name="Blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_mucosa" isDefault="1" displayUnit="l/min">
                       <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
                       <Info min="0" flag="122" seq="303" ref="0" bb="32" group="5" />
                     </Parameter>
-                    <Parameter id="ZhvNRZBLnk6em15uSXpaWg" name="Fraction intracellular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_f_cell" isDefault="1">
+                    <Parameter id="bug-DAKft0qjJ4laaxrZyQ" name="Fraction intracellular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_f_cell" isDefault="1">
                       <Info min="0" max="1" flag="62" seq="343" ref="0" bb="32" group="64" />
                     </Parameter>
-                    <Parameter id="kt84_fRrxUuaKVd9_sQcHw" name="Density (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
+                    <Parameter id="T20aamWgXk2_6WuR-1pWaQ" name="Density (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
                       <Info min="0" flag="38" seq="1" ref="0" bb="32" group="21" />
                     </Parameter>
-                    <Parameter id="1KrXquC9o0CdmUbyLFLpDg" name="Fraction mucosa" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.13">
-                      <Info min="0" max="1" flag="58" seq="1" ref="0" bb="32" group="40" />
+                    <Parameter id="KnOaOuvuZUKMjp9O2uGrdQ" name="Fraction mucosa" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.13">
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+                            <Parameter id="qdD6OKiV_EaGOxOl4th4rg" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Plasma_and_Interstitial" isDefault="1" displayUnit="µmol/l">
                               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                               <Info flag="52" seq="1" ref="0" bb="2" group="25" />
                             </Parameter>
-                            <Parameter id="MZgvg0f7AkG_HFzFpwKP0w" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                            <Parameter id="dBeD-nO85k6Fv22Og3n4CQ" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                             </Parameter>
-                            <Parameter id="ng6PlQbfHEOcbxWqX-4m3w" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" isDefault="1">
+                            <Parameter id="IJCM4l3ujkSVnXrv2sBCVg" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                             </Parameter>
-                            <Parameter id="N0NvMGLiaky3g0Pg_EAeDw" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                            <Parameter id="AY1sko2qAUq7sQ4cjwjz2g" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
                               <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                             </Parameter>
                           </Children>
                         </Container>
                       </Children>
                     </Container>
-                    <Container id="CC0ua551hUe7JcUHHqnPAA" name="BloodCells" mode="Physical" containerType="Compartment">
+                    <Container id="IziOa_FtaUqUAIU572OpQA" name="BloodCells" mode="Physical" containerType="Compartment">
                       <Tags>
                         <Tag value="Mucosa" />
                         <Tag value="SmallIntestineSegment" />
                         <Tag value="UpperIleum" />
                       </Tags>
                       <Children>
-                        <Parameter id="ZQwB2gRuOEqHeReP7fr7UA" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                        <Parameter id="Q_xzf0Fs1kCudRIzUSzqDQ" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
                           <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                         </Parameter>
-                        <Parameter id="wunndxz2TU-6Cbn8p6ogow" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_bc_2Pores" isDefault="1" displayUnit="l">
+                        <Parameter id="pF373NGQ8E2I-DZGCRbsJw" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_bc_2Pores" isDefault="1" displayUnit="l">
                           <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                           <Info min="0" flag="62" seq="114" ref="0" bb="2" group="121" />
                         </Parameter>
-                        <Container id="ifp1CRgQvEGSpjh9VcO3Wg" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                        <Container id="2HUdrGd5_Um2z7Xa9wqcfw" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                           <Children>
-                            <Parameter id="EcT51dTKyU6E-wDncGusLQ" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                            <Parameter id="19Eu7uAYK0-bESetGIAfeA" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                             </Parameter>
-                            <Parameter id="J4WOrl2oIE-kfkteViqsTg" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" isDefault="1">
+                            <Parameter id="j0SnX9UFk0CiFPZ-sRv-tw" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                             </Parameter>
-                            <Parameter id="xB-pCyJrrUSaD7wlbsu4rQ" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                            <Parameter id="p1ucWdCMGEu57Kxjak760A" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
                               <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                             </Parameter>
                           </Children>
                         </Container>
                       </Children>
                     </Container>
-                    <Container id="e7ovU8l5RUCMTI7XZC6cJA" name="Interstitial" mode="Physical" containerType="Compartment">
+                    <Container id="TgQCETCCSEWkzmP_6RVIrA" name="Interstitial" mode="Physical" containerType="Compartment">
                       <Tags>
                         <Tag value="Mucosa" />
                         <Tag value="SmallIntestineSegment" />
                         <Tag value="UpperIleum" />
                       </Tags>
                       <Children>
-                        <Parameter id="cR9lfM-sXUKV1E1SLq6ghA" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
-                          <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
-                        </Parameter>
-                        <Parameter id="5-kdaTHtCEScngHSFDJsiA" name="FcRn concentration in container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.FcRn_in_Container_Interstitial" isDefault="1" displayUnit="µmol/l">
+                        <Parameter id="1-Z4gGJJDEOvmTFQ70vX2g" name="FcRn concentration in container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.FcRn_in_Container_Interstitial" isDefault="1" displayUnit="µmol/l">
                           <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                           <Info flag="52" seq="1" ref="0" bb="2" group="25" />
                         </Parameter>
-                        <Parameter id="SumceyFo9kOPiO2w9sN-AA" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_int_2Pores" isDefault="1" displayUnit="l">
+                        <Parameter id="hg564kxl7UaMYVYjmjWPKA" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                          <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                        </Parameter>
+                        <Parameter id="Cm5E5lZi40a0N2K2rtNPdw" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_int_2Pores" isDefault="1" displayUnit="l">
                           <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                           <Info min="0" flag="62" seq="114" ref="0" bb="2" group="124" />
                         </Parameter>
-                        <Parameter id="iLnBbAgFIUOZ1htOrijKUg" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_pH_INT" isDefault="1">
+                        <Parameter id="vSxdW0hhy0Kg6SHcM-Gw2Q" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_pH_INT" isDefault="1">
                           <Tags>
                             <Tag value="Mucosa" />
                             <Tag value="SmallIntestineSegment" />
@@ -9050,26 +9107,26 @@
                           </Tags>
                           <Info min="0" max="14" flag="122" seq="344" ref="0" bb="32" group="84" />
                         </Parameter>
-                        <Container id="Xa6Fb6sfi0mF9ahBcx-F0A" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                        <Container id="0nofutVvQkqnos8dK4F46A" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                           <Children>
-                            <Parameter id="-j2Vm7pZ2EaGziKH60gaAg" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Plasma_and_Interstitial" isDefault="1" displayUnit="µmol/l">
+                            <Parameter id="IPCcbjDKf0S9Qia76WjPwA" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Plasma_and_Interstitial" isDefault="1" displayUnit="µmol/l">
                               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                               <Info flag="52" seq="1" ref="0" bb="2" group="25" />
                             </Parameter>
-                            <Parameter id="yvd4d08XIkWkdvNaojGkbg" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                            <Parameter id="p7I1F4OHbEiA09cWEc5eSw" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                             </Parameter>
-                            <Parameter id="igqFGYL9i0WPlHDAj_wmTA" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_uil" isDefault="1">
+                            <Parameter id="o__cWakHS0m29Sz389YxEQ" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_uil" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                             </Parameter>
-                            <Parameter id="_XHT3y0D6kmT92aP1Hu9dQ" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                            <Parameter id="NgNGw6tikkWfTHWJDyf2xQ" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
                               <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                             </Parameter>
                           </Children>
                         </Container>
                       </Children>
                     </Container>
-                    <Container id="HuwaRp7cAkOPSAeW5XiPPQ" name="Intracellular" mode="Physical" containerType="Compartment">
+                    <Container id="EYZAa4Yzr0StY62D_vb3Aw" name="Intracellular" mode="Physical" containerType="Compartment">
                       <Tags>
                         <Tag value="IntestinalSecretionSource" />
                         <Tag value="Mucosa" />
@@ -9077,14 +9134,14 @@
                         <Tag value="UpperIleum" />
                       </Tags>
                       <Children>
-                        <Parameter id="ClglJ2K1XE6tVQA-XknjxQ" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" isDefault="1" displayUnit="l">
+                        <Parameter id="7LSAORd-nkC8SQhDMydbYQ" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" isDefault="1" displayUnit="l">
                           <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                         </Parameter>
-                        <Parameter id="CWKNRBp7AEazxgY-LfBy0w" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_cell_2Pores" isDefault="1" displayUnit="l">
+                        <Parameter id="hulKt2PAykOlQK4J7Le4Ag" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_cell_2Pores" isDefault="1" displayUnit="l">
                           <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                           <Info min="0" flag="62" seq="114" ref="0" bb="2" group="125" />
                         </Parameter>
-                        <Parameter id="94wlvAnGqkODLNX-GdTbAQ" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.3">
+                        <Parameter id="gEFBpZ0eKE6hfJZtCapw4g" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.3">
                           <Tags>
                             <Tag value="IntestinalSecretionSource" />
                             <Tag value="Mucosa" />
@@ -9094,296 +9151,296 @@
                           <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
                           <Info min="0" max="14" flag="122" seq="344" ref="0" bb="32" group="83" />
                         </Parameter>
-                        <Container id="Yx-V1x3Np0-lNOpNSHoFWA" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                        <Container id="Lg8OGvncPE2rqPk6jx6Gmg" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                           <Children>
-                            <Parameter id="6SvIqFnnyU-IXd0Cy-6W-w" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_uil" isDefault="1">
-                              <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
-                            </Parameter>
-                            <Parameter id="RWj2f7J-d064q98VbBmQrg" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                            <Parameter id="_JMkZyD4UU2rkk6Q3Y3xTQ" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                             </Parameter>
-                            <Parameter id="00dJ1Jbf30-9vjgukR2oww" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                            <Parameter id="rafGMK2VwUOqxh7hTm_eug" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_uil" isDefault="1">
+                              <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                            </Parameter>
+                            <Parameter id="bQ9dVcf-0EGWUG2jVMeeMg" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
                               <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                             </Parameter>
                           </Children>
                         </Container>
                       </Children>
                     </Container>
-                    <Container id="E6Z_d5Ekf0-1Qt-q6haIgQ" name="Endosome" mode="Physical" containerType="Compartment">
+                    <Container id="oprSVXgs6UiqUo97LBVdeg" name="Endosome" mode="Physical" containerType="Compartment">
                       <Tags>
                         <Tag value="Mucosa" />
                         <Tag value="SmallIntestineSegment" />
                         <Tag value="UpperIleum" />
                       </Tags>
                       <Children>
-                        <Parameter id="9vwZHHCvtEaQjVXvgTLQlg" name="FcRn concentration in container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.FcRn_in_Container_Endosomal" isDefault="1" displayUnit="µmol/l">
+                        <Parameter id="oGEOTbNgZk-KlGM4W0tB4Q" name="FcRn concentration in container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.FcRn_in_Container_Endosomal" isDefault="1" displayUnit="µmol/l">
                           <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                           <Info flag="52" seq="1" ref="0" bb="2" group="25" />
                         </Parameter>
-                        <Parameter id="cJabmo_dVUuiA9oHZILrIQ" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                        <Parameter id="KvoCvKKZEUezvL9_SHLWXw" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
                           <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                         </Parameter>
-                        <Parameter id="cQrY7xMRAEi9wycLQHqqTQ" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_end_uil" isDefault="1" displayUnit="l">
+                        <Parameter id="eEgcq4fdikOrm80XeMDY-A" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_end_uil" isDefault="1" displayUnit="l">
                           <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                           <Info min="0" flag="122" seq="114" ref="0" bb="2" group="123" />
                         </Parameter>
-                        <Container id="JtkOBW8VbUCKUHuvQP4Dlg" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                        <Container id="JzVBMkwDe0C1davzppg_SQ" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                           <Children>
-                            <Parameter id="tO6VMvrPAkm1qhLldizZaw" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Endosomal" isDefault="1" displayUnit="µmol/l">
+                            <Parameter id="10iqp7zWT06f6CXKpuGKRA" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Endosomal" isDefault="1" displayUnit="µmol/l">
                               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                               <Info flag="52" seq="1" ref="0" bb="2" group="25" />
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-                        <Parameter id="HeYlhmT5gEqDv50bEEzqfg" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_pH_INT" isDefault="1">
+                        <Parameter id="xU9N3jaCGEWXMpQKpVAQCQ" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_pH_INT" isDefault="1">
                           <Tags>
                             <Tag value="LowerIleum" />
                             <Tag value="Mucosa" />
@@ -9391,26 +9448,26 @@
                           </Tags>
                           <Info min="0" max="14" flag="122" seq="347" ref="0" bb="32" group="84" />
                         </Parameter>
-                        <Container id="4uE-dxVWpkad4bPhxx8j2w" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                        <Container id="AeKB8Z_kvkagc-nsoyfELA" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                           <Children>
-                            <Parameter id="37F2MEs0w0Sw6noRBOsOEQ" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Plasma_and_Interstitial" isDefault="1" displayUnit="µmol/l">
+                            <Parameter id="t-9sjlpRi0OiGm8jnVDmMg" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Plasma_and_Interstitial" isDefault="1" displayUnit="µmol/l">
                               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                               <Info flag="52" seq="1" ref="0" bb="2" group="25" />
                             </Parameter>
-                            <Parameter id="5D11LyEIAEWqb_92JRgb7g" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                            <Parameter id="e1g3-z7CuEmVOfWobPp6sQ" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                             </Parameter>
-                            <Parameter id="6XrOhnA74EuKrQyJm-Hxbg" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_lil" isDefault="1">
+                            <Parameter id="CPu1pgQRg0qAdm5PSAg9Hw" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_lil" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                             </Parameter>
-                            <Parameter id="DTeIftxM0keu4xTiCwjmuw" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                            <Parameter id="dIg6M3e96UWW07CfXBmhpA" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
                               <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                             </Parameter>
                           </Children>
                         </Container>
                       </Children>
                     </Container>
-                    <Container id="YQIFE44fnUK9EweUet_HyA" name="Intracellular" mode="Physical" containerType="Compartment">
+                    <Container id="hlUQz3rRx0mOPW0NjWkgEA" name="Intracellular" mode="Physical" containerType="Compartment">
                       <Tags>
                         <Tag value="IntestinalSecretionSource" />
                         <Tag value="LowerIleum" />
@@ -9418,14 +9475,14 @@
                         <Tag value="SmallIntestineSegment" />
                       </Tags>
                       <Children>
-                        <Parameter id="0LverfnTBUqzgZWei5Jkew" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" isDefault="1" displayUnit="l">
+                        <Parameter id="k-OD8cm-uEiCoMWwkguaPQ" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" isDefault="1" displayUnit="l">
                           <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                         </Parameter>
-                        <Parameter id="n9BKosfsFk6-VBskM_I5MQ" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_cell_2Pores" isDefault="1" displayUnit="l">
+                        <Parameter id="ju-ivc3Y5U29k2x54KOLfQ" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_cell_2Pores" isDefault="1" displayUnit="l">
                           <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                           <Info min="0" flag="62" seq="115" ref="0" bb="2" group="125" />
                         </Parameter>
-                        <Parameter id="b9UND97_Bk-WFYMz89IoQg" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.3">
+                        <Parameter id="Z7sdawRMuUa-QUFKH_YdUQ" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.3">
                           <Tags>
                             <Tag value="IntestinalSecretionSource" />
                             <Tag value="LowerIleum" />
@@ -9435,129 +9492,130 @@
                           <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
                           <Info min="0" max="14" flag="122" seq="347" ref="0" bb="32" group="83" />
                         </Parameter>
-                        <Container id="3SEUf2HsX0GWz00eDVOsqg" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                        <Container id="4D9kh9_oFU-ptDYnuFVc6A" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                           <Children>
-                            <Parameter id="k2g3gsdE1UyYwyQmUJFXDQ" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                            <Parameter id="ylfv3AsOyEeAEKx9Ga2Ygw" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                             </Parameter>
-                            <Parameter id="PiQ3Ibleq06bdL6-3L1zSQ" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_lil" isDefault="1">
+                            <Parameter id="jpNFxqaAAk2vMkWOORvDlg" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_lil" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                             </Parameter>
-                            <Parameter id="p3HxlbSx5Eu8k2OcPKu11g" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                            <Parameter id="jt_NtnqSykSHtZSyGlq7Vw" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
                               <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                             </Parameter>
                           </Children>
                         </Container>
                       </Children>
                     </Container>
-                    <Container id="shrK2TdNH02S6E0s1Zz1uQ" name="Endosome" mode="Physical" containerType="Compartment">
+                    <Container id="7kchle5bt0yvnRYwDCp1VQ" name="Endosome" mode="Physical" containerType="Compartment">
                       <Tags>
                         <Tag value="LowerIleum" />
                         <Tag value="Mucosa" />
                         <Tag value="SmallIntestineSegment" />
                       </Tags>
                       <Children>
-                        <Parameter id="RHXOLLLY7U6rj-hByOxPnw" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
-                          <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
-                        </Parameter>
-                        <Parameter id="x6tpTtVMWUesHZoV8Bdhhg" name="FcRn concentration in container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.FcRn_in_Container_Endosomal" isDefault="1" displayUnit="µmol/l">
+                        <Parameter id="vTT4Cohz8USvFxthuZAgkw" name="FcRn concentration in container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.FcRn_in_Container_Endosomal" isDefault="1" displayUnit="µmol/l">
                           <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                           <Info flag="52" seq="1" ref="0" bb="2" group="25" />
                         </Parameter>
-                        <Parameter id="VBIB10vWtUqToMR3o2u0Bg" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_end_lil" isDefault="1" displayUnit="l">
+                        <Parameter id="lvAqRPaI2USNrT6eoMMj3g" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                          <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                        </Parameter>
+                        <Parameter id="8jEOJ9QSi0ubbZXJkVNzSg" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_end_lil" isDefault="1" displayUnit="l">
                           <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                           <Info min="0" flag="122" seq="115" ref="0" bb="2" group="123" />
                         </Parameter>
-                        <Container id="Oj86sq7ZkkSbIYHUvkrrxA" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                        <Container id="BAfWsHgxXUioZtDoSDiU-Q" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                           <Children>
-                            <Parameter id="DTxZ8SDGL0KmEGFVv0ytEw" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Endosomal" isDefault="1" displayUnit="µmol/l">
+                            <Parameter id="K2RQjUNqUEul9iL7H26oyw" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Endosomal" isDefault="1" displayUnit="µmol/l">
                               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                               <Info flag="52" seq="1" ref="0" bb="2" group="25" />
                             </Parameter>
-                            <Parameter id="xxnQZmAzY02IYGXYfdAYxw" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                            <Parameter id="idpLR95XhUyt0eohVl5fHA" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                             </Parameter>
-                            <Parameter id="iIq4PMKFSEGjtZAWujxHrg" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
-                              <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
-                            </Parameter>
-                            <Parameter id="hH8T8aQHr0yYe6q9d7AYdg" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                            <Parameter id="F6ja0n1ugkKZ91eGVOV33w" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
                               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                             </Parameter>
+                            <Parameter id="06QTrvJUB0-Gs46Q-W0Q6g" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                              <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                            </Parameter>
                           </Children>
                         </Container>
                       </Children>
                     </Container>
-                    <Container id="Z7kxdnit00CLG_3pWZVB2g" name="MoleculeProperties" mode="Logical" containerType="Molecule" />
+                    <Container id="EKCSgMF1oEy0xiicG8ZkTA" name="MoleculeProperties" mode="Logical" containerType="Molecule" />
                   </Children>
                 </Container>
               </Children>
             </Container>
           </Children>
         </Container>
-        <Container id="ouhz5RgBHEKs58v45jEiWw" name="LargeIntestine" mode="Logical" containerType="Organ">
+        <Container id="KDsQJJSIgkyrdRfATojDlQ" name="LargeIntestine" mode="Logical" containerType="Organ">
           <Tags>
             <Tag value="Portal Vein Supplying Organ" />
             <Tag value="TissueOrgan" />
           </Tags>
           <Children>
-            <Parameter id="Ij2BTuZprki_FFTasenoKw" name="Fraction of endosomal uptake from plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_uptake_vas" isDefault="1">
+            <Parameter id="3jGKDNwNLUSuxFAl-mlpkg" name="Fraction of endosomal uptake from plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_uptake_vas" isDefault="1">
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
               <Info min="0" flag="54" seq="0" ref="0" bb="2" group="25" />
             </Parameter>
-            <Parameter id="TRUFshDQ70q3YGdZh-zstQ" name="Fraction endosomal" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_endo" isDefault="1">
+            <Parameter id="duYtylJKd0a7aVi2U0TaEw" name="Fraction endosomal" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_endo" isDefault="1">
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
               <Info min="0" max="1" flag="54" seq="1" ref="0" bb="2" group="29" />
             </Parameter>
-            <Parameter id="Pvy8bYSLQUGvP-gHCZelEQ" name="Fraction recycled to plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_rec_vas" isDefault="1">
+            <Parameter id="VmLGf9pcdEC9LgHL6I2eOw" name="Fraction recycled to plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_rec_vas" isDefault="1">
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
               <Info min="0" flag="54" seq="1" ref="0" bb="2" group="25" />
             </Parameter>
-            <Parameter id="_mEMG2J4wEG4GnYsupLjoQ" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
-              <Tags>
-                <Tag value="Portal Vein Supplying Organ" />
-                <Tag value="TissueOrgan" />
-              </Tags>
-              <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
-            </Parameter>
-            <Parameter id="zycSbgnFnk-uhl31yau2fA" name="Volume (mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="MucosaVolume.VOLUME_LargeIntestineMucosa" isDefault="1" displayUnit="l">
+            <Parameter id="0FUJ0HwYXUWjAAfX_sN4VQ" name="Large intestinal transit time factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_LITT_Factor" isDefault="1">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
-              <Info min="0" flag="62" seq="1" ref="0" bb="32" group="129" />
+              <Info min="0" flag="38" seq="1" ref="0" bb="32" group="46" />
             </Parameter>
-            <Parameter id="X0TjVZyvs0m6Hv9AeLqjTQ" name="Rate constant for recycling from endosomal space" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_K_rec" isDefault="1" displayUnit="1/min">
+            <Parameter id="JNds9aKUWUCWf03QooEuKg" name="Rate constant for endosomal uptake" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_K_uptake" isDefault="1" displayUnit="1/min">
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
               <Info min="0" flag="54" seq="1" ref="0" bb="2" group="25" />
             </Parameter>
-            <Parameter id="ROz67hT8dkicrhnQ4plwsw" name="Rate constant for endosomal uptake" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_K_uptake" isDefault="1" displayUnit="1/min">
+            <Parameter id="vka-IIbBj0GT71_LqXxSpg" name="Rate constant for recycling from endosomal space" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_K_rec" isDefault="1" displayUnit="1/min">
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
               <Info min="0" flag="54" seq="1" ref="0" bb="2" group="25" />
             </Parameter>
-            <Parameter id="p9sPyDrSmkuF6EDI2Ea5fg" name="Large intestinal transit time factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_LITT_Factor" isDefault="1">
+            <Parameter id="RbRxy-B1lUKnXg7lu_rF0w" name="Volume (mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="MucosaVolume.VOLUME_LargeIntestineMucosa" isDefault="1" displayUnit="l">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
-              <Info min="0" flag="38" seq="1" ref="0" bb="32" group="46" />
+              <Info min="0" flag="62" seq="1" ref="0" bb="32" group="129" />
+            </Parameter>
+            <Parameter id="zti40NWCP0eRJrao90R70g" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
+              <Tags>
+                <Tag value="Portal Vein Supplying Organ" />
+                <Tag value="TissueOrgan" />
+              </Tags>
+              <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
             </Parameter>
-            <Parameter id="klrG2ySWlkak6A3_bDqAkA" name="Fluid recirculation flow rate (incl. mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate" isDefault="1" displayUnit="l/min">
+            <Parameter id="tKWALLvJEUuY2UkoD9uqVA" name="Fluid recirculation flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_FluidRecirculationRate_lin" isDefault="1" displayUnit="l/min">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-              <Info min="0" flag="122" seq="16" ref="0" bb="32" group="27" />
+              <Info min="0" flag="62" seq="16" ref="0" bb="32" group="27" />
             </Parameter>
-            <Parameter id="MJVST-MgG0eaBDwpmNlx8g" name="Volume (endothelium)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="VascularEndoVolume.VOLUME_VascularEndo_lin" isDefault="1" displayUnit="l">
+            <Parameter id="lzPoDslHy0OU_9d1MFvDXg" name="Fluid recirculation flow rate (incl. mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate" isDefault="1" displayUnit="l/min">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
-              <Info min="0" flag="62" seq="16" ref="0" bb="32" group="127" />
+              <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+              <Info min="0" flag="122" seq="16" ref="0" bb="32" group="27" />
             </Parameter>
-            <Parameter id="YZ9646mfZEWHcyZaHcyBIg" name="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_Lymph_lin" isDefault="1" displayUnit="l/min">
+            <Parameter id="nv97fa_yc0y3MH6Av6IVmg" name="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_Lymph_lin" isDefault="1" displayUnit="l/min">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
@@ -9565,7 +9623,7 @@
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
               <Info min="0" flag="62" seq="16" ref="0" bb="32" group="58" />
             </Parameter>
-            <Parameter id="aNsdzZDyIkuXsshQlfB7QA" name="Lymph flow rate (incl. mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Lymph_flow_rate" isDefault="1" displayUnit="l/min">
+            <Parameter id="06D4Vfex0U6b1K72_1fJQw" name="Lymph flow rate (incl. mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Lymph_flow_rate" isDefault="1" displayUnit="l/min">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
@@ -9573,155 +9631,154 @@
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
               <Info min="0" flag="122" seq="16" ref="0" bb="32" group="58" />
             </Parameter>
-            <Parameter id="fl-gsaeNgkCFQ8Yd4RX5Ww" name="Fluid recirculation flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_FluidRecirculationRate_lin" isDefault="1" displayUnit="l/min">
+            <Parameter id="52B4MVYOYkKcoSXEWpEyWA" name="Volume (endothelium)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="VascularEndoVolume.VOLUME_VascularEndo_lin" isDefault="1" displayUnit="l">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
-              <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-              <Info min="0" flag="62" seq="16" ref="0" bb="32" group="27" />
+              <Info min="0" flag="62" seq="16" ref="0" bb="32" group="127" />
             </Parameter>
-            <Parameter id="Mj7mpoB73k615mgCvxRgsw" name="Fraction intracellular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_f_cell" isDefault="1">
+            <Parameter id="115t7xWm3ECggqqQgf_Z1g" name="Fraction intracellular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_f_cell" isDefault="1">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" max="1" flag="62" seq="49" ref="0" bb="32" group="64" />
             </Parameter>
-            <Parameter id="8wgncldMz0m38AAyrX7X_Q" name="Blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_from_Qspec" isDefault="1" displayUnit="l/min">
+            <Parameter id="6bvzdqWWAkS9gnjgDjs1iw" name="Blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_from_Qspec" isDefault="1" displayUnit="l/min">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
-              <ValueOrigin id="48" description="TODO: Absolute from specific calculation" />
+              <ValueOrigin id="48" source="Other" description="Absolute value = specific value (i.e. value normalized to the volume of the organ) multiplied by the organ volume" />
               <Info min="0" flag="62" seq="122" ref="0" bb="32" group="5" />
             </Parameter>
-            <Parameter id="1XF_naHp9E-7IpRkaSlKKQ" name="Organ volume mouse" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.000627" displayUnit="l">
+            <Parameter id="VM7HRZ8JaUiuLXKG4Gqgrg" name="Density (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
-              <Info min="0" flag="54" seq="1" ref="0" bb="32" group="65" />
+              <Info min="0" flag="38" seq="1" ref="0" bb="32" group="21" />
             </Parameter>
-            <Parameter id="rNq1IGQd1kih_f7FJqXlkQ" name="Density (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
+            <Parameter id="rkYALn1AdEiPe_733K2ytQ" name="Fluid recirculation flow proportionality factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.179">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
-              <Info min="0" flag="38" seq="1" ref="0" bb="32" group="21" />
+              <Info min="0" flag="54" seq="1" ref="0" bb="32" group="27" />
             </Parameter>
-            <Parameter id="S-NOUW_ZMUCwlYPDGun_rQ" name="Fluid recirculation flow proportionality factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.179">
+            <Parameter id="bFNWuidRZkK4BqC_XbalwA" name="Lymph flow proportionality factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0144">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
-              <Info min="0" flag="54" seq="1" ref="0" bb="32" group="27" />
+              <Info min="0" flag="54" seq="1" ref="0" bb="32" group="58" />
             </Parameter>
-            <Parameter id="AIqdm64tuEWllcDgw-Tkrw" name="Lymph flow proportionality factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0144">
+            <Parameter id="YGwAYwn04EuIWB3EiF6g9w" name="Organ volume mouse" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.000627" displayUnit="l">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
-              <Info min="0" flag="54" seq="1" ref="0" bb="32" group="58" />
+              <Info min="0" flag="54" seq="1" ref="0" bb="32" group="65" />
             </Parameter>
-            <Parameter id="uiJQKDQ4BU2rNRitoq_k6Q" name="Allometric scale factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.75">
+            <Parameter id="VSpyBlKPR0eiDXMa6SjFVA" name="Allometric scale factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.75">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0.75" max="0.75" flag="54" seq="1" ref="0" bb="32" group="2" />
             </Parameter>
-            <Parameter id="ktvYr549Vkiu8RYFtAK2rA" name="Mucosa blood flow fraction" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.75">
+            <Parameter id="FbrOgj66mkqMF81P2332fg" name="Large intestinal transit time factor intercept" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="47.6">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
-              <Info min="0" flag="54" seq="1" ref="0" bb="32" group="39" />
+              <Info flag="52" seq="1" ref="0" bb="32" group="46" />
             </Parameter>
-            <Parameter id="z9-iF6yZ-0i5PhrbeyLmbg" name="Large intestinal transit time factor slope" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.938" displayUnit="1/min">
+            <Parameter id="nPVbRvlNlE2uPSZL1c7OWQ" name="Large intestinal transit time factor slope" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.938" displayUnit="1/min">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info flag="52" seq="1" ref="0" bb="32" group="46" />
             </Parameter>
-            <Parameter id="3oD0yladtkCoAE-sx9EmVQ" name="Large intestinal transit time factor intercept" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="47.6">
+            <Parameter id="1VMPJjkwUEGbD4D39Fh4ow" name="Mucosa blood flow fraction" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.75">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
-              <Info flag="52" seq="1" ref="0" bb="32" group="46" />
+              <Info min="0" flag="54" seq="1" ref="0" bb="32" group="39" />
             </Parameter>
-            <Parameter id="DDuKA9qMoEKt2FAooM4sXA" name="Fraction of blood for sampling" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+            <Parameter id="MBJmIke_FUWA-2F0jbiO-A" name="Fraction of blood for sampling" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" max="1" flag="54" seq="1" ref="0" bb="32" group="94" />
             </Parameter>
-            <Parameter id="BXiIRH6Um0OyZ_kHmDX1Ig" name="Radius (large pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.5E-07" displayUnit="µm">
+            <Parameter id="O9JSdn02PEejnJlrBfg2cA" name="Flow fraction via large pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.05">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-              <Info min="0" flag="122" seq="16" ref="0" bb="32" group="55" />
+              <Info min="0" max="1" flag="122" seq="16" ref="0" bb="32" group="114" />
             </Parameter>
-            <Parameter id="EgCKi8pQNUyVE6BVPWrTaQ" name="Flow fraction via large pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.05">
+            <Parameter id="4giBiKBAnkaC_YnaWtZ38Q" name="Hydraulic conductivity" icon="Parameter" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.86944444444444E-10" displayUnit="ml/min/N">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-              <Info min="0" max="1" flag="122" seq="16" ref="0" bb="32" group="114" />
+              <Info min="0" flag="122" seq="16" ref="0" bb="32" group="115" />
             </Parameter>
-            <Parameter id="8OIEGfOO0UmCzb4HYkZUMg" name="Radius (small pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="4.5E-08" displayUnit="µm">
+            <Parameter id="Udjuo8VQB069Rm6udw5oYQ" name="Radius (large pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.5E-07" displayUnit="µm">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-              <Info min="0" flag="122" seq="16" ref="0" bb="32" group="99" />
+              <Info min="0" flag="122" seq="16" ref="0" bb="32" group="55" />
             </Parameter>
-            <Parameter id="nhW2sqjYekOYH0tVlRshww" name="Hydraulic conductivity" icon="Parameter" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.86944444444444E-10" displayUnit="ml/min/N">
+            <Parameter id="oXOc1AASGUymhG1LSm65Hg" name="Radius (small pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="4.5E-08" displayUnit="µm">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-              <Info min="0" flag="122" seq="16" ref="0" bb="32" group="115" />
+              <Info min="0" flag="122" seq="16" ref="0" bb="32" group="99" />
             </Parameter>
-            <Parameter id="cOfyljMGW0SIGuEgcb4fCQ" name="Vf (lipid)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.062">
+            <Parameter id="EBmBub4rHkuomNSYakzu_w" name="Fraction vascular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.024">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
-              <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
-              <Info min="0" max="1" flag="122" seq="48" ref="0" bb="32" group="85" />
+              <ValueOrigin id="19" source="Publication" description="Kawai R, Lemaire M, Steimer JL, Bruelisauer A, Niederberger W, Rowland M. Physiologically based pharmacokinetic study on a cyclosporin derivative, SDZ IMM 125. J Pharmacokinet Biopharm. 1994 Oct;22(5):327-65." />
+              <Info min="0" max="1" flag="62" seq="48" ref="0" bb="32" group="64" />
             </Parameter>
-            <Parameter id="FuQd1H8f6EKS04PPeZObTQ" name="Vf (neutral lipid)-PT" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0487">
+            <Parameter id="F9bWGKT_akeAhPaeVY__EA" name="Vf (lipid)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.062">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
-              <Info min="0" max="1" flag="122" seq="48" ref="0" bb="32" group="86" />
+              <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
+              <Info min="0" max="1" flag="122" seq="48" ref="0" bb="32" group="85" />
             </Parameter>
-            <Parameter id="X5qRm-F3nk6dBrhbL2r6HQ" name="Fraction vascular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.024">
+            <Parameter id="Ld3FQF-pZkyCxloxElaIsQ" name="Vf (neutral lipid)-PT" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0487">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
-              <ValueOrigin id="19" source="Publication" description="Kawai R, Lemaire M, Steimer JL, Bruelisauer A, Niederberger W, Rowland M. Physiologically based pharmacokinetic study on a cyclosporin derivative, SDZ IMM 125. J Pharmacokinet Biopharm. 1994 Oct;22(5):327-65." />
-              <Info min="0" max="1" flag="62" seq="48" ref="0" bb="32" group="64" />
+              <Info min="0" max="1" flag="122" seq="48" ref="0" bb="32" group="86" />
             </Parameter>
-            <Parameter id="_LtUnD6HmEypsUPqw5XW7g" name="Vf (phospholipid)-PT" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0163">
+            <Parameter id="WMLyNHX2rE2z14u2oMQOXw" name="Vf (phospholipid)-PT" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0163">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" max="1" flag="122" seq="49" ref="0" bb="32" group="86" />
             </Parameter>
-            <Parameter id="CcqEacjpIkaDaiFX2Ea4Lg" name="Vf (protein)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.133">
+            <Parameter id="N1D4MAV-SUOksagD25FB1w" name="Vf (protein)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.133">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
@@ -9729,7 +9786,15 @@
               <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
               <Info min="0" max="1" flag="122" seq="49" ref="0" bb="32" group="85" />
             </Parameter>
-            <Parameter id="UIe5EthHjEeitCPVRUEMMA" name="Albumin ratio (tissue/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.158">
+            <Parameter id="ybNx0197ikeD3AZNmm2lrA" name="Fraction interstitial" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.094">
+              <Tags>
+                <Tag value="Portal Vein Supplying Organ" />
+                <Tag value="TissueOrgan" />
+              </Tags>
+              <ValueOrigin id="19" source="Publication" description="Kawai R, Lemaire M, Steimer JL, Bruelisauer A, Niederberger W, Rowland M. Physiologically based pharmacokinetic study on a cyclosporin derivative, SDZ IMM 125. J Pharmacokinet Biopharm. 1994 Oct;22(5):327-65." />
+              <Info min="0" max="1" flag="62" seq="50" ref="0" bb="32" group="64" />
+            </Parameter>
+            <Parameter id="qM_CCo6euk-vYncBi17Q4w" name="Albumin ratio (tissue/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.158">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
@@ -9737,7 +9802,7 @@
               <ValueOrigin id="22" source="Publication" description="Rodgers T, Rowland M. Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J Pharm Sci. 2006 Jun;95(6):1238-57 https://doi.org/10.1002/jps.20502" />
               <Info min="0" max="1" flag="122" seq="50" ref="0" bb="32" group="111" />
             </Parameter>
-            <Parameter id="NJ2vM14240C9O2uXcrvoMw" name="Albumin ratio (tissue/plasma)-PT" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+            <Parameter id="_1NUhkgi4EmgbTyatnk9yg" name="Albumin ratio (tissue/plasma)-PT" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
@@ -9745,7 +9810,7 @@
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+            <Parameter id="xbNWZGVa60a4i5UnyWn1mw" name="Lipoprotein ratio (tissue/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.141">
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@@ -9753,7 +9818,7 @@
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+            <Parameter id="-whjXPcuHk6bR6Ns4NwCcw" name="Vf (water)-PT" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.718">
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+            <Parameter id="WpoUrE3WuUewl5Rx389MRg" name="Vf (neutral lipid)-WS" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0483">
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@@ -9806,14 +9856,14 @@
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+            <Parameter id="HlhvuB0ea0OIg2IzBwnHRg" name="Vf (neutral phospholipid, plasma)-WS" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0182">
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                 <Tag value="TissueOrgan" />
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-              <Info min="0" max="1" flag="122" seq="82" ref="0" bb="32" group="95" />
+              <Info min="0" max="1" flag="122" seq="81" ref="0" bb="32" group="95" />
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+            <Parameter id="4fydNxYI-0C8gcOQYaYMzg" name="Vf (extracellular water)-RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.282">
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@@ -9821,14 +9871,14 @@
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+            <Parameter id="SLX-53q4LUqcHQwLAkCRwg" name="Vf (protein)-WS" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.15">
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                 <Tag value="TissueOrgan" />
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-              <Info min="0" max="1" flag="122" seq="83" ref="0" bb="32" group="95" />
+              <Info min="0" max="1" flag="122" seq="82" ref="0" bb="32" group="95" />
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+            <Parameter id="Em1rYZg6ekGNMLBTZEz0TA" name="Vf (intracellular water)-RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.456">
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@@ -9836,14 +9886,14 @@
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+            <Parameter id="n85bt0y0nUiIgkFd_25uJw" name="Vf (water)-WS" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.78">
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                 <Tag value="TissueOrgan" />
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-              <Info min="0" max="1" flag="122" seq="84" ref="0" bb="32" group="95" />
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+            <Parameter id="obykPpk1PEq2N3Lb3LS7ww" name="Acidic phospholipids [mg/g] - RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.41">
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+            <Parameter id="ZFLPxZ3B7k-Zj3r-4rW5vQ" name="Vf (acidic phospholipids)-WS" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0035">
+              <Tags>
+                <Tag value="Portal Vein Supplying Organ" />
+                <Tag value="TissueOrgan" />
+              </Tags>
+              <Info min="0" max="1" flag="122" seq="84" ref="0" bb="32" group="95" />
+            </Parameter>
+            <DistributedParameter id="WcUCl_WxBEi-Q09yTdSJRA" name="Large intestinal transit time" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="9UHDbVYrbUGAdGHw4p5gaQ" mode="Logical" isDefault="1" displayUnit="h">
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+                <Parameter id="SDijuQXyC02uXkhnecrM8A" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5" displayUnit="h">
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+                <Parameter id="DcSaSdC1ikKfjCSyZsz7fg" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2652" displayUnit="h">
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@@ -9866,15 +9923,15 @@
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+            <DistributedParameter id="xrYtIz0aBUOARSqrZ0ejVw" name="Volume" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="A85YZyJHsU2UM8Wc2MSxtA" mode="Logical" isDefault="1" displayUnit="l">
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+                <Parameter id="GrNG6g2AWUO6kJmqWeviWw" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.501964262652174" displayUnit="l">
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+                <Parameter id="gpD7fZRFL0O5nMDAXHOB6A" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.41217159744" displayUnit="l">
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+                <Parameter id="cRg2QbnJA0ug2gSpLd_-bg" name="Deviation" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.080576347522488" displayUnit="l">
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@@ -9882,17 +9939,18 @@
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
+              <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
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+            <DistributedParameter id="UrXuxMQnjE6hVNDUt3mkPg" name="Specific blood flow rate" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" formula="NDx1vfhMA0SDSOVmzzLf1A" mode="Logical" isDefault="1" displayUnit="ml/min/100g organ">
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+                <Parameter id="GdHfP-7a6kiQsGwMoeP5ug" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5" displayUnit="ml/min/100g organ">
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+                <Parameter id="B6JvfvN6wk-SmDaK8_aEHg" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.6305" displayUnit="ml/min/100g organ">
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+                <Parameter id="2IFe9Yoh90iaGpH9ZyfLig" name="Deviation" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.031525" displayUnit="ml/min/100g organ">
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                 </Parameter>
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@@ -9900,423 +9958,424 @@
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
+              <ValueOrigin id="40" source="Publication" description="Edginton, A.N., Schmitt, W. &amp; Willmann, S. Clin Pharmacokinet (2006) 45: 1013. https://doi.org/10.2165/00003088-200645100-00005" />
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             </DistributedParameter>
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+            <Container id="RNkPLFnn1Eepynm3sVKH1g" name="Plasma" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="LargeIntestine" />
                 <Tag value="Portal Vein Supplying Organ" />
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               <Children>
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+                <Parameter id="ZRlRQWbMHUG_Tg0kus8U2w" name="FcRn concentration in container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.FcRn_in_Container_Plasma" isDefault="1" displayUnit="µmol/l">
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+                <Parameter id="GwHrwG289kCwZjm9Yq6tOg" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
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+                <Parameter id="2uq7Xc1WYk2_RkXl7MbGMA" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_pls_SinLin" isDefault="1" displayUnit="l">
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                 </Parameter>
-                <Container id="-7LlxAxEF0uGcq2BorQ1Bw" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="lTTAQcb-90O0poxXRJC-IQ" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                   <Children>
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+                        <Parameter id="i9ykmKTAxUK7Qwf35wOpEg" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_pH_INT" isDefault="1">
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+                            <Parameter id="5lR_avW42kae5FdKSqXysQ" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Plasma_and_Interstitial" isDefault="1" displayUnit="µmol/l">
                               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                               <Info flag="52" seq="1" ref="0" bb="2" group="25" />
                             </Parameter>
-                            <Parameter id="51ZUESzn4EKyN7F_g7-yiw" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                            <Parameter id="CqfKpDRMYEeOrjXX4-BfVw" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                             </Parameter>
-                            <Parameter id="WHwM93u2BEqkxZj06_UNVw" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_cae" isDefault="1">
+                            <Parameter id="R37mTBIrX0CK8ZkcT7nXiA" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_cae" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                             </Parameter>
-                            <Parameter id="rrv23SbIH0ew3iE17_VmRA" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                            <Parameter id="82pq3-_BZkKmCv5msMd3xw" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
                               <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                             </Parameter>
                           </Children>
                         </Container>
                       </Children>
                     </Container>
-                    <Container id="1YH-god92USKlp7JoWKh7g" name="Intracellular" mode="Physical" containerType="Compartment">
+                    <Container id="AxF00LW0V0eNOPUgpupvmQ" name="Intracellular" mode="Physical" containerType="Compartment">
                       <Tags>
                         <Tag value="Caecum" />
                         <Tag value="IntestinalSecretionSource" />
@@ -10351,14 +10410,14 @@
                         <Tag value="Mucosa" />
                       </Tags>
                       <Children>
-                        <Parameter id="Y-upW0MwLk2i7mFF62dtGw" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" isDefault="1" displayUnit="l">
+                        <Parameter id="241xyMwIukWIJPZDjWmT9Q" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" isDefault="1" displayUnit="l">
                           <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                         </Parameter>
-                        <Parameter id="T4u-_9BzR0eYtxZJezl_pw" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_cell_2Pores" isDefault="1" displayUnit="l">
+                        <Parameter id="Gcsoc3JbQkSk6mBe3BvgEA" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_cell_2Pores" isDefault="1" displayUnit="l">
                           <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                           <Info min="0" flag="62" seq="116" ref="0" bb="2" group="125" />
                         </Parameter>
-                        <Parameter id="yIBm-2P-tkiZ8xqyXBEVbQ" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.3">
+                        <Parameter id="WUO6DIIJyEy-Bdu6ou2T6w" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.3">
                           <Tags>
                             <Tag value="Caecum" />
                             <Tag value="IntestinalSecretionSource" />
@@ -10368,296 +10427,296 @@
                           <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
                           <Info min="0" max="14" flag="122" seq="350" ref="0" bb="32" group="83" />
                         </Parameter>
-                        <Container id="PNds1vdAu0ST5zdjYzTMKQ" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                        <Container id="KSrWBCk9GECUxLW9G0Nlzw" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                           <Children>
-                            <Parameter id="9jkh5gdIW0GA0jCN1mceNQ" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                            <Parameter id="XmhX7hgbZEiW0xk68cvbWg" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                             </Parameter>
-                            <Parameter id="D1BB1igl-E2QpGNVG1Ds0Q" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_cae" isDefault="1">
+                            <Parameter id="dly9uysyNUm5hQGF8G4XLg" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_cae" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                             </Parameter>
-                            <Parameter id="IN3_lfMj0Eedo5joE8XSrg" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                            <Parameter id="GwF7fevZukWhXQDfeOCjdA" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
                               <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                             </Parameter>
                           </Children>
                         </Container>
                       </Children>
                     </Container>
-                    <Container id="7jrMdPP5LU-OWvDwCJxoLg" name="Endosome" mode="Physical" containerType="Compartment">
+                    <Container id="VkZeqlnX2k2zVyoiwzUaag" name="Endosome" mode="Physical" containerType="Compartment">
                       <Tags>
                         <Tag value="Caecum" />
                         <Tag value="LargeIntestineSegment" />
                         <Tag value="Mucosa" />
                       </Tags>
                       <Children>
-                        <Parameter id="qSvzsSan90uSQRFm2wKRxQ" name="FcRn concentration in container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.FcRn_in_Container_Endosomal" isDefault="1" displayUnit="µmol/l">
+                        <Parameter id="kXi2TQ6I2Uyh71nxCc4prg" name="FcRn concentration in container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.FcRn_in_Container_Endosomal" isDefault="1" displayUnit="µmol/l">
                           <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                           <Info flag="52" seq="1" ref="0" bb="2" group="25" />
                         </Parameter>
-                        <Parameter id="NA_zLVGDF0iN3YZ0g4WtQQ" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                        <Parameter id="xkLp5J2WFUm7w8r4uE7Gxw" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
                           <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                         </Parameter>
-                        <Parameter id="pyrAN-VOvk-nOlrukaw9TQ" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_end_cae" isDefault="1" displayUnit="l">
+                        <Parameter id="fz0YHuCxuUaCtJXTy8JFxA" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_end_cae" isDefault="1" displayUnit="l">
                           <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                           <Info min="0" flag="122" seq="116" ref="0" bb="2" group="123" />
                         </Parameter>
-                        <Container id="2kspJ-e3bUWJv35H_Xt2Tg" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                        <Container id="j6I1eEALJkud4S5jXaZ93w" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                           <Children>
-                            <Parameter id="ja-ELEDRm0SkuxxMlyUeqw" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
-                              <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
-                            </Parameter>
-                            <Parameter id="H33Z73YewEWxjbBwDAlqzg" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Endosomal" isDefault="1" displayUnit="µmol/l">
+                            <Parameter id="Nt2EEp0oIEyVKtdme2evxA" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Endosomal" isDefault="1" displayUnit="µmol/l">
                               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                               <Info flag="52" seq="1" ref="0" bb="2" group="25" />
                             </Parameter>
-                            <Parameter id="aCRem6zPV0eQVMElN5UDmA" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                            <Parameter id="EOOLRPUio0ecl6Bw4EmkJQ" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                             </Parameter>
-                            <Parameter id="DWvYuIEmkUKkXbyyD-5pCw" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                            <Parameter id="SYRH-4lzwUmGWM5PnCbv2Q" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
                               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                             </Parameter>
+                            <Parameter id="WsclpUG6m0GFNm3sYZtaPg" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                              <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                            </Parameter>
                           </Children>
                         </Container>
                       </Children>
                     </Container>
-                    <Container id="N_xh-hjqB0uFWxcIHBUr0w" name="MoleculeProperties" mode="Logical" containerType="Molecule" />
+                    <Container id="3tJh-OnEakmKTDr8qNhp4w" name="MoleculeProperties" mode="Logical" containerType="Molecule" />
                   </Children>
                 </Container>
-                <Container id="AOjheQ5-f0mVobmXXWrWig" name="ColonAscendens" mode="Logical" containerType="Compartment">
+                <Container id="yOVMbR_ypkSxePujQo52Bg" name="ColonAscendens" mode="Logical" containerType="Compartment">
                   <Children>
-                    <Parameter id="FaXzl4UQqkeCHViC4l4GaQ" name="Fraction of endosomal uptake from plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_uptake_vas" isDefault="1">
+                    <Parameter id="pMz6niGimEqCHc4FoHVWKg" name="Fraction of endosomal uptake from plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_uptake_vas" isDefault="1">
                       <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                       <Info min="0" flag="54" seq="0" ref="0" bb="2" group="25" />
                     </Parameter>
-                    <Parameter id="D7Itu7EBxkKxBE_yv0o8zA" name="Fraction endosomal" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_endo" isDefault="1">
+                    <Parameter id="_vOenbhihUiaIP29Ht9y-w" name="Fraction endosomal" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_endo" isDefault="1">
                       <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                       <Info min="0" max="1" flag="54" seq="1" ref="0" bb="2" group="29" />
                     </Parameter>
-                    <Parameter id="C028yXoBdkOIpHF35k0ayQ" name="Fraction recycled to plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_rec_vas" isDefault="1">
+                    <Parameter id="T1QaUi64zEiXs9c60ZIEcw" name="Fraction recycled to plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_rec_vas" isDefault="1">
                       <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                       <Info min="0" flag="54" seq="1" ref="0" bb="2" group="25" />
                     </Parameter>
-                    <Parameter id="biL7gP34CU6apcWPY2qcYg" name="Rate constant for endosomal uptake" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_K_uptake" isDefault="1" displayUnit="1/min">
+                    <Parameter id="3lxdICle-UGICmCi3UbR3A" name="Rate constant for endosomal uptake" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_K_uptake" isDefault="1" displayUnit="1/min">
                       <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                       <Info min="0" flag="54" seq="1" ref="0" bb="2" group="25" />
                     </Parameter>
-                    <Parameter id="YQLthEtwXUqulO1CMB-p6Q" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
-                      <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
-                    </Parameter>
-                    <Parameter id="AbPw85MlcUmaRXlsf91VdA" name="Rate constant for recycling from endosomal space" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_K_rec" isDefault="1" displayUnit="1/min">
+                    <Parameter id="7BsBtJBW2Uyz0Nahc40cGA" name="Rate constant for recycling from endosomal space" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_K_rec" isDefault="1" displayUnit="1/min">
                       <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                       <Info min="0" flag="54" seq="1" ref="0" bb="2" group="25" />
                     </Parameter>
-                    <Parameter id="RLUrWkgJ_06cGGoHFzz6-w" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="MucosaVolume.VOLUME_MucosaColonAscendens" isDefault="1" displayUnit="l">
+                    <Parameter id="XCq01DCZ40W43FyQfKnfaw" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
+                    </Parameter>
+                    <Parameter id="b07_xj3VK02D_Xh2khfM2w" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="MucosaVolume.VOLUME_MucosaColonAscendens" isDefault="1" displayUnit="l">
                       <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
                       <Info min="0" flag="122" seq="26" ref="0" bb="32" group="65" />
                     </Parameter>
-                    <Parameter id="4rsFWRcQrkGCv_qYOFIDkw" name="Volume (endothelium)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="VascularEndoVolume.VOLUME_VascularEndo_colasc" isDefault="1" displayUnit="l">
-                      <Info min="0" flag="62" seq="117" ref="0" bb="32" group="127" />
+                    <Parameter id="E4_kbv0BpUSBW6JDr7Uvww" name="Fluid recirculation flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_J_iso_Mucosa" isDefault="1" displayUnit="l/min">
+                      <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                      <Info min="0" flag="122" seq="117" ref="0" bb="32" group="27" />
                     </Parameter>
-                    <Parameter id="51u6isGCtk2X5pt8B6m8Jg" name="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_lymph_mucosa" isDefault="1" displayUnit="l/min">
+                    <Parameter id="qzAHhKqc0ESlRFRZyN97uQ" name="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_lymph_mucosa" isDefault="1" displayUnit="l/min">
                       <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                       <Info min="0" flag="122" seq="117" ref="0" bb="32" group="58" />
                     </Parameter>
-                    <Parameter id="mvHKKLBytU6nRPfohSUw-g" name="Fluid recirculation flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_J_iso_Mucosa" isDefault="1" displayUnit="l/min">
-                      <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-                      <Info min="0" flag="122" seq="117" ref="0" bb="32" group="27" />
+                    <Parameter id="lai-fK4wi0W6ufVzWdzBoQ" name="Volume (endothelium)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="VascularEndoVolume.VOLUME_VascularEndo_colasc" isDefault="1" displayUnit="l">
+                      <Info min="0" flag="62" seq="117" ref="0" bb="32" group="127" />
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                           <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                           <Info flag="52" seq="1" ref="0" bb="2" group="25" />
                         </Parameter>
-                        <Parameter id="-06UDnnnmkmcZbCB1xteGw" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                        <Parameter id="Z52zTSGqpESR8nEtqPIRcg" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
                           <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                         </Parameter>
-                        <Parameter id="07mZB9ApikGXt8TtmIMKww" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_pls_2Pores" isDefault="1" displayUnit="l">
+                        <Parameter id="XDAQGe0XzkGQ0Oyu-aeEIg" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_pls_2Pores" isDefault="1" displayUnit="l">
                           <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                           <Info min="0" flag="62" seq="117" ref="0" bb="2" group="126" />
                         </Parameter>
-                        <Container id="9D6bsKK6aky0fjltg2Fwbg" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                        <Container id="8BxiHfnUdECaN78R9bRncQ" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                           <Children>
-                            <Parameter id="rhn8J7M0zU-TGVLhwBooeA" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Plasma_and_Interstitial" isDefault="1" displayUnit="µmol/l">
+                            <Parameter id="cjlwpCVcAECwc7yv_4xTWQ" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Plasma_and_Interstitial" isDefault="1" displayUnit="µmol/l">
                               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                               <Info flag="52" seq="1" ref="0" bb="2" group="25" />
                             </Parameter>
-                            <Parameter id="u3fEMv-vRkenHqAvIXYeRg" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                            <Parameter id="fMj2npcFkU26g5V1V8lerA" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                             </Parameter>
-                            <Parameter id="Gzuh1cicL0a79znEcqC0LQ" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" isDefault="1">
+                            <Parameter id="yXAS53SyEEW0r8B7h1UADQ" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                             </Parameter>
-                            <Parameter id="RdRdR4k0Jk6VW71IlZtNuQ" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                            <Parameter id="wDQ8IalKXUuF8VLMb6Uc9w" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
                               <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                             </Parameter>
                           </Children>
                         </Container>
                       </Children>
                     </Container>
-                    <Container id="qmb47oXwu06rIgurXdkdAg" name="BloodCells" mode="Physical" containerType="Compartment">
+                    <Container id="Zh1OO87Y9kW0nA9-toCWqg" name="BloodCells" mode="Physical" containerType="Compartment">
                       <Tags>
                         <Tag value="ColonAscendens" />
                         <Tag value="LargeIntestineSegment" />
                         <Tag value="Mucosa" />
                       </Tags>
                       <Children>
-                        <Parameter id="fRtDBJr_TkedQUsfNqQOlA" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                        <Parameter id="CTOQmxf3f0uz9-DycJp7vA" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
                           <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                         </Parameter>
-                        <Parameter id="BSBcUsyxR0a2i7qJ6R3AVA" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_bc_2Pores" isDefault="1" displayUnit="l">
+                        <Parameter id="W73hLxLjk0ytVYmajdw15w" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_bc_2Pores" isDefault="1" displayUnit="l">
                           <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                           <Info min="0" flag="62" seq="117" ref="0" bb="2" group="121" />
                         </Parameter>
-                        <Container id="yVcMcB8_z0arJ61Zl9Lhjg" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                        <Container id="8uSyLdTev0Wcr9v0bGuDdQ" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                           <Children>
-                            <Parameter id="ZOvP1XTaJkiflZCCfyOuFQ" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                            <Parameter id="IGa2booIgUCgbkwNafo7QA" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                             </Parameter>
-                            <Parameter id="PC2Idivr7EuvjdudzDLuKg" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" isDefault="1">
+                            <Parameter id="gtFZzCrJ5U2lxt8orwEZzA" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                             </Parameter>
-                            <Parameter id="GhTdND1GfEejpJW-QCIK3A" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                            <Parameter id="tC5_wYNGUEiULZdKMTYF9A" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
                               <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                             </Parameter>
                           </Children>
                         </Container>
                       </Children>
                     </Container>
-                    <Container id="wCHFevfEAUa4gfNBCIYr1A" name="Interstitial" mode="Physical" containerType="Compartment">
+                    <Container id="qJFpi2VrMUevujlAbgi63Q" name="Interstitial" mode="Physical" containerType="Compartment">
                       <Tags>
                         <Tag value="ColonAscendens" />
                         <Tag value="LargeIntestineSegment" />
                         <Tag value="Mucosa" />
                       </Tags>
                       <Children>
-                        <Parameter id="k0TA69nsyEqbPEOtKkUhKw" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
-                          <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
-                        </Parameter>
-                        <Parameter id="W1nKAvZqZESv4bCOjkrPQw" name="FcRn concentration in container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.FcRn_in_Container_Interstitial" isDefault="1" displayUnit="µmol/l">
+                        <Parameter id="1czyOK1WFECz7WYKIAsJKw" name="FcRn concentration in container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.FcRn_in_Container_Interstitial" isDefault="1" displayUnit="µmol/l">
                           <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                           <Info flag="52" seq="1" ref="0" bb="2" group="25" />
                         </Parameter>
-                        <Parameter id="V1c7A9KlXUGcRoMv-OYgxg" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_int_2Pores" isDefault="1" displayUnit="l">
+                        <Parameter id="kvIhiN-UPUOLZopjcSe-1g" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                          <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                        </Parameter>
+                        <Parameter id="_iqTDDbroU6N1UH5X0E-Xw" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_int_2Pores" isDefault="1" displayUnit="l">
                           <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                           <Info min="0" flag="62" seq="117" ref="0" bb="2" group="124" />
                         </Parameter>
-                        <Parameter id="pfgU7kaagEeAH1WcHms6tg" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_pH_INT" isDefault="1">
+                        <Parameter id="NByAqKI2m0O3OybLsy9JCg" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_pH_INT" isDefault="1">
                           <Tags>
                             <Tag value="ColonAscendens" />
                             <Tag value="LargeIntestineSegment" />
@@ -10665,26 +10724,26 @@
                           </Tags>
                           <Info min="0" max="14" flag="122" seq="353" ref="0" bb="32" group="84" />
                         </Parameter>
-                        <Container id="MmIjokyLpEqYZcLKH0xXwQ" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                        <Container id="ufy0joPpxkePE2gA5xMgYQ" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                           <Children>
-                            <Parameter id="6dKP-5OKlEa-9et5__DNkg" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Plasma_and_Interstitial" isDefault="1" displayUnit="µmol/l">
+                            <Parameter id="FkZ9iA02okC3ax0PJMjpBw" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Plasma_and_Interstitial" isDefault="1" displayUnit="µmol/l">
                               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                               <Info flag="52" seq="1" ref="0" bb="2" group="25" />
                             </Parameter>
-                            <Parameter id="piOKu1AnOUGQ3RUbP2TC-Q" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                            <Parameter id="sZGit1RKRUarcMk_GhYTKw" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                             </Parameter>
-                            <Parameter id="gPuGcj1YiUqKXdUUcTFm_A" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_colasc" isDefault="1">
+                            <Parameter id="_IJaj5fYH0iVeBm--oPXkQ" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_colasc" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                             </Parameter>
-                            <Parameter id="M0FenRMYO023o7fnrzky1A" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                            <Parameter id="9CP3b5jUI0iIu0rxr7q__g" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
                               <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                             </Parameter>
                           </Children>
                         </Container>
                       </Children>
                     </Container>
-                    <Container id="EQk07EvEgUeogHnziDRsgg" name="Intracellular" mode="Physical" containerType="Compartment">
+                    <Container id="S-Rw4kxIuk2Mzq3AJUGeAg" name="Intracellular" mode="Physical" containerType="Compartment">
                       <Tags>
                         <Tag value="ColonAscendens" />
                         <Tag value="IntestinalSecretionSource" />
@@ -10692,14 +10751,14 @@
                         <Tag value="Mucosa" />
                       </Tags>
                       <Children>
-                        <Parameter id="iQJmQhIYo0e2Q8NqXO-YCg" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" isDefault="1" displayUnit="l">
+                        <Parameter id="xE5ruetyw0OTlgfAOWT8Rg" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" isDefault="1" displayUnit="l">
                           <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                         </Parameter>
-                        <Parameter id="VK83I9NSJEmJhXDNta3wjQ" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_cell_2Pores" isDefault="1" displayUnit="l">
+                        <Parameter id="YSrC4qm37kiwj0xbtP-UdQ" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_cell_2Pores" isDefault="1" displayUnit="l">
                           <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                           <Info min="0" flag="62" seq="117" ref="0" bb="2" group="125" />
                         </Parameter>
-                        <Parameter id="TWEIKZvIJkOEDUndJoj1Dg" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.3">
+                        <Parameter id="a7qdgooj_UOa2qRYpIjMIA" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.3">
                           <Tags>
                             <Tag value="ColonAscendens" />
                             <Tag value="IntestinalSecretionSource" />
@@ -10709,296 +10768,296 @@
                           <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
                           <Info min="0" max="14" flag="122" seq="353" ref="0" bb="32" group="83" />
                         </Parameter>
-                        <Container id="aHtjCplwz0qqxTLbThEdeg" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                        <Container id="WJlu38FMkUiLonqWQqDUVQ" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                           <Children>
-                            <Parameter id="HwJQd_M5A0Szy0ip9IvCow" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                            <Parameter id="BygUFEo1nEuqnr01YWQfjQ" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                             </Parameter>
-                            <Parameter id="V3Apz8vYTEa74lvxc2C1ew" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_colasc" isDefault="1">
+                            <Parameter id="QRtTCE1dBE6geuomco1_NQ" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_colasc" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                             </Parameter>
-                            <Parameter id="89fof4ZE7Ua0AzwVUVDjYA" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                            <Parameter id="lC3i7tsbv0S5iuk1MlsxYQ" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
                               <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                             </Parameter>
                           </Children>
                         </Container>
                       </Children>
                     </Container>
-                    <Container id="n8plCFVxRUyMCVvFBce5zg" name="Endosome" mode="Physical" containerType="Compartment">
+                    <Container id="m3uhNYhC00O1U6ih730LVQ" name="Endosome" mode="Physical" containerType="Compartment">
                       <Tags>
                         <Tag value="ColonAscendens" />
                         <Tag value="LargeIntestineSegment" />
                         <Tag value="Mucosa" />
                       </Tags>
                       <Children>
-                        <Parameter id="kJRRzT6XY0WiO2B4y17LnA" name="FcRn concentration in container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.FcRn_in_Container_Endosomal" isDefault="1" displayUnit="µmol/l">
+                        <Parameter id="QWAaKToKEUq_RGu9p9fqJQ" name="FcRn concentration in container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.FcRn_in_Container_Endosomal" isDefault="1" displayUnit="µmol/l">
                           <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                           <Info flag="52" seq="1" ref="0" bb="2" group="25" />
                         </Parameter>
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+                        <Parameter id="otDAnZ43nku6nh5-dg9Xsg" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
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                       <Children>
-                        <Parameter id="blirgynX7EyZPyceoiiWzA" name="FcRn concentration in container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.FcRn_in_Container_Interstitial" isDefault="1" displayUnit="µmol/l">
+                        <Parameter id="PkXRwfpje0akeNF-jYz4kw" name="FcRn concentration in container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.FcRn_in_Container_Interstitial" isDefault="1" displayUnit="µmol/l">
                           <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                           <Info flag="52" seq="1" ref="0" bb="2" group="25" />
                         </Parameter>
-                        <Parameter id="Km8FRtuQUUOz42dndGmFzg" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                        <Parameter id="fIaESdtsSkakrMkyNq9fsg" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
                           <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                         </Parameter>
-                        <Parameter id="o4qoUhlCJUyR5ndU-aR3tw" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_int_2Pores" isDefault="1" displayUnit="l">
+                        <Parameter id="aRa3iac7Ikm2iig4YN9tQg" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_int_2Pores" isDefault="1" displayUnit="l">
                           <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                           <Info min="0" flag="62" seq="118" ref="0" bb="2" group="124" />
                         </Parameter>
-                        <Parameter id="rKWiSCrjs02w7iQW5cahXA" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_pH_INT" isDefault="1">
+                        <Parameter id="6CR7SIw2ME-3Fpg10K3Baw" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_pH_INT" isDefault="1">
                           <Tags>
                             <Tag value="ColonTransversum" />
                             <Tag value="LargeIntestineSegment" />
@@ -11006,26 +11065,26 @@
                           </Tags>
                           <Info min="0" max="14" flag="122" seq="356" ref="0" bb="32" group="84" />
                         </Parameter>
-                        <Container id="LPw4yGH350qR4eSrcbUZRg" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                        <Container id="IbzmScifXEWqdNrCEwz7YQ" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                           <Children>
-                            <Parameter id="IexVBxZG9kmcMlowNQOaJg" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
-                              <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
-                            </Parameter>
-                            <Parameter id="o8VvjR3Azki6Oy_YxP7VfA" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Plasma_and_Interstitial" isDefault="1" displayUnit="µmol/l">
+                            <Parameter id="kL75RH-iGEmFJ9SCoH0R7A" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Plasma_and_Interstitial" isDefault="1" displayUnit="µmol/l">
                               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                               <Info flag="52" seq="1" ref="0" bb="2" group="25" />
                             </Parameter>
-                            <Parameter id="S7qLAGWu0UujZipCxw-O8g" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                            <Parameter id="G2skxGNu1UC0-7MlLeh8WQ" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                             </Parameter>
-                            <Parameter id="18Yqqh3UhkKig-ksnNRxgQ" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_coltrans" isDefault="1">
+                            <Parameter id="7Bcb3N7S20u_P1fdROdLLw" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_coltrans" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                             </Parameter>
+                            <Parameter id="8VvSbizDl0u5yCnUUDBADQ" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                              <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                            </Parameter>
                           </Children>
                         </Container>
                       </Children>
                     </Container>
-                    <Container id="_8WPOqeesEqTiq7LFrBEqQ" name="Intracellular" mode="Physical" containerType="Compartment">
+                    <Container id="9Lccn4BuWUWFz52tXH9heA" name="Intracellular" mode="Physical" containerType="Compartment">
                       <Tags>
                         <Tag value="ColonTransversum" />
                         <Tag value="IntestinalSecretionSource" />
@@ -11033,14 +11092,14 @@
                         <Tag value="Mucosa" />
                       </Tags>
                       <Children>
-                        <Parameter id="Qxbqoo4DZEOnrQnkKfbzSQ" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" isDefault="1" displayUnit="l">
+                        <Parameter id="yY0GmgcRzEmUSh-NQpI5mg" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" isDefault="1" displayUnit="l">
                           <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                         </Parameter>
-                        <Parameter id="NC9eUFwkQESDre-rmrkDnA" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_cell_2Pores" isDefault="1" displayUnit="l">
+                        <Parameter id="5mdzF_JE50m2g_cqeI9tVw" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_cell_2Pores" isDefault="1" displayUnit="l">
                           <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                           <Info min="0" flag="62" seq="118" ref="0" bb="2" group="125" />
                         </Parameter>
-                        <Parameter id="dli2u33N2UCl_HCqY_nHhQ" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.3">
+                        <Parameter id="y0e1nXXBJkOgMwetKRJIOw" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.3">
                           <Tags>
                             <Tag value="ColonTransversum" />
                             <Tag value="IntestinalSecretionSource" />
@@ -11050,296 +11109,296 @@
                           <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
                           <Info min="0" max="14" flag="122" seq="356" ref="0" bb="32" group="83" />
                         </Parameter>
-                        <Container id="dk1Hiz2nTUmU0sT1dIVc2A" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                        <Container id="FFxb3VpbkEqLBSvA4xJhrA" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                           <Children>
-                            <Parameter id="GGziEbXHsU-siJhzC5GTog" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_coltrans" isDefault="1">
+                            <Parameter id="iMayU1zqP02ugdyFF1-9UA" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                              <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                            </Parameter>
+                            <Parameter id="cLdnNpsXfUmQ7Yn0kYLJjg" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_coltrans" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                             </Parameter>
-                            <Parameter id="x9PzEBFy70GDX5LLJ5ALdg" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                            <Parameter id="gz0_wcFI0kSbHyMFhI92Xw" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
                               <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                             </Parameter>
-                            <Parameter id="dKbXNip0PkK1jOdXbAOhxw" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
-                              <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
-                            </Parameter>
                           </Children>
                         </Container>
                       </Children>
                     </Container>
-                    <Container id="CUxvDoRgnU2bpbsrSbe4FQ" name="Endosome" mode="Physical" containerType="Compartment">
+                    <Container id="8HOX-hTtFEWc10EOdFIELg" name="Endosome" mode="Physical" containerType="Compartment">
                       <Tags>
                         <Tag value="ColonTransversum" />
                         <Tag value="LargeIntestineSegment" />
                         <Tag value="Mucosa" />
                       </Tags>
                       <Children>
-                        <Parameter id="XB4sG3XRh0eSIYp6fmv8eA" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
-                          <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
-                        </Parameter>
-                        <Parameter id="bplO6w3HQkScJJPOo3Hx9g" name="FcRn concentration in container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.FcRn_in_Container_Endosomal" isDefault="1" displayUnit="µmol/l">
+                        <Parameter id="h73BdWAV8UmRbpbpax0G_A" name="FcRn concentration in container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.FcRn_in_Container_Endosomal" isDefault="1" displayUnit="µmol/l">
                           <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                           <Info flag="52" seq="1" ref="0" bb="2" group="25" />
                         </Parameter>
-                        <Parameter id="--_dfO6O6USmG4SccZsRKA" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_end_coltrans" isDefault="1" displayUnit="l">
+                        <Parameter id="gVPimj-IxUG3Z50Cb5pnNA" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                          <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                        </Parameter>
+                        <Parameter id="g0c9DGI5zUKUkU5TTkNtFA" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_end_coltrans" isDefault="1" displayUnit="l">
                           <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                           <Info min="0" flag="122" seq="118" ref="0" bb="2" group="123" />
                         </Parameter>
-                        <Container id="mex39EqaJ0WeUVAGJIzN-Q" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                        <Container id="dL_Iv-1y50mTcq2rzAqu8w" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                           <Children>
-                            <Parameter id="HNDQaA7VqECeNbd1c4OEqw" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Endosomal" isDefault="1" displayUnit="µmol/l">
+                            <Parameter id="t2n-83IyQkaKfTayz0EyKQ" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Endosomal" isDefault="1" displayUnit="µmol/l">
                               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                               <Info flag="52" seq="1" ref="0" bb="2" group="25" />
                             </Parameter>
-                            <Parameter id="QZR6Qb2xOEqSG3FkPoTPWQ" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                            <Parameter id="ZDOpM340E0ys926Vu2Ar8Q" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                             </Parameter>
-                            <Parameter id="UFPUp9sA6kGxiEzpWgKj4w" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                            <Parameter id="oORAgr8zYUa6he_uiktnVA" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
                               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                             </Parameter>
-                            <Parameter id="HJdKNEL_kEax-0wFKeFrig" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                            <Parameter id="Cdz8MyEmUkmDqRmbwHeC9A" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
                               <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                             </Parameter>
                           </Children>
                         </Container>
                       </Children>
                     </Container>
-                    <Container id="K8pXbM4JkUyAxKhFlFoG1Q" name="MoleculeProperties" mode="Logical" containerType="Molecule" />
+                    <Container id="jMlxhiIXx0-I8bLHdq6TfQ" name="MoleculeProperties" mode="Logical" containerType="Molecule" />
                   </Children>
                 </Container>
-                <Container id="06uBkCExxkiXOGJN3sf5jw" name="ColonDescendens" mode="Logical" containerType="Compartment">
+                <Container id="Cocu_tlcy02AeOLDi84T1A" name="ColonDescendens" mode="Logical" containerType="Compartment">
                   <Children>
-                    <Parameter id="8QZYiO8Pl0qupNAF3cWohA" name="Fraction of endosomal uptake from plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_uptake_vas" isDefault="1">
+                    <Parameter id="UMPZDp40o0uSOx7cxUxtvA" name="Fraction of endosomal uptake from plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_uptake_vas" isDefault="1">
                       <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                       <Info min="0" flag="54" seq="0" ref="0" bb="2" group="25" />
                     </Parameter>
-                    <Parameter id="EnnoTgAq_UmUd3SeCmWo0g" name="Rate constant for endosomal uptake" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_K_uptake" isDefault="1" displayUnit="1/min">
+                    <Parameter id="8I9p4WtFtkK-7Geo5RnUtg" name="Fraction endosomal" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_endo" isDefault="1">
                       <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="25" />
+                      <Info min="0" max="1" flag="54" seq="1" ref="0" bb="2" group="29" />
                     </Parameter>
-                    <Parameter id="LNJD5z9R6EqyfOEa7rdsxA" name="Rate constant for recycling from endosomal space" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_K_rec" isDefault="1" displayUnit="1/min">
+                    <Parameter id="UKbWmwva0UKAKo8YZRFJYg" name="Fraction recycled to plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_rec_vas" isDefault="1">
                       <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                       <Info min="0" flag="54" seq="1" ref="0" bb="2" group="25" />
                     </Parameter>
-                    <Parameter id="AuoUdYORTECIDD2vRxZJnA" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
-                      <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
-                    </Parameter>
-                    <Parameter id="BtmGmeCstE6UajMJeyfIaw" name="Fraction recycled to plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_rec_vas" isDefault="1">
+                    <Parameter id="XsGwbgUof0aBlHL6tncmcg" name="Rate constant for endosomal uptake" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_K_uptake" isDefault="1" displayUnit="1/min">
                       <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                       <Info min="0" flag="54" seq="1" ref="0" bb="2" group="25" />
                     </Parameter>
-                    <Parameter id="zhLEWsinZEWfshOh61KxvQ" name="Fraction endosomal" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_endo" isDefault="1">
+                    <Parameter id="jlN2M3m10EavBGgFaRlhJg" name="Rate constant for recycling from endosomal space" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_K_rec" isDefault="1" displayUnit="1/min">
                       <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-                      <Info min="0" max="1" flag="54" seq="1" ref="0" bb="2" group="29" />
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="25" />
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+                    <Parameter id="gSGOuxyEAUq4Obq08MUzvw" name="Vf (intracellular water)-RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.456">
                       <ValueOrigin id="22" source="Publication" description="Rodgers T, Rowland M. Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J Pharm Sci. 2006 Jun;95(6):1238-57 https://doi.org/10.1002/jps.20502" />
                       <Info min="0" max="1" flag="122" seq="598" ref="0" bb="32" group="92" />
                     </Parameter>
-                    <Parameter id="SKWxRsET-U6NB-H8EjwRMA" name="Acidic phospholipids [mg/g] - RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.41">
+                    <Parameter id="8630PElW0Eaj6Nm9_pe7wA" name="Vf (water)-WS" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.78">
+                      <Info min="0" max="1" flag="122" seq="598" ref="0" bb="32" group="95" />
+                    </Parameter>
+                    <Parameter id="KUkD-7379UC6xctapLfEIQ" name="Acidic phospholipids [mg/g] - RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.41">
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+                    <Parameter id="-qSlNH3KxEaHF86Woo1-LA" name="Vf (acidic phospholipids)-WS" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0035">
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                     </Parameter>
-                    <Container id="vL02efQGCU-ZjeiGD2sJSg" name="Plasma" mode="Physical" containerType="Compartment">
+                    <Container id="jZAZ-gTMf0KikSh_Nm6c8Q" name="Plasma" mode="Physical" containerType="Compartment">
                       <Tags>
                         <Tag value="ColonDescendens" />
                         <Tag value="LargeIntestineSegment" />
                         <Tag value="Mucosa" />
                       </Tags>
                       <Children>
-                        <Parameter id="Ak9aNoqXE0y-hcOjbUXsEQ" name="FcRn concentration in container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.FcRn_in_Container_Plasma" isDefault="1" displayUnit="µmol/l">
+                        <Parameter id="iVxsXUxzxUivpLd48kmdcQ" name="FcRn concentration in container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.FcRn_in_Container_Plasma" isDefault="1" displayUnit="µmol/l">
                           <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                           <Info flag="52" seq="1" ref="0" bb="2" group="25" />
                         </Parameter>
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+                        <Parameter id="G_4CePeasEeyYjjuk8hutA" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
                           <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                         </Parameter>
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+                        <Parameter id="U2BlktgfRkuvv99SkjKjNA" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_pls_2Pores" isDefault="1" displayUnit="l">
                           <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                           <Info min="0" flag="62" seq="119" ref="0" bb="2" group="126" />
                         </Parameter>
-                        <Container id="OW_vZ89c10qJ5ac368w5iw" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                        <Container id="sfQO_Ch5QUy2ozFSafyE-g" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                           <Children>
-                            <Parameter id="CSO84P_5HUqIeBEXfs10Vw" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Plasma_and_Interstitial" isDefault="1" displayUnit="µmol/l">
+                            <Parameter id="L6fJmwxAjk2Kh8qzqakGFQ" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Plasma_and_Interstitial" isDefault="1" displayUnit="µmol/l">
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                               <Info flag="52" seq="1" ref="0" bb="2" group="25" />
                             </Parameter>
-                            <Parameter id="u-bw7qYSAEWxwlEvlS4Bgg" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                            <Parameter id="FT3iyBlJu0KSWzkHjDHVEQ" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                             </Parameter>
-                            <Parameter id="nrdEl5COe02JjOionZim4g" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" isDefault="1">
+                            <Parameter id="hCP24vzGv0y2ZnQAvcH4Pw" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                             </Parameter>
-                            <Parameter id="K5uGon6eG0WnFVognM9B9w" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                            <Parameter id="hAI-krfYiU65C9jzl98XYg" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
                               <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                             </Parameter>
                           </Children>
                         </Container>
                       </Children>
                     </Container>
-                    <Container id="dwf9qubqqEi4D7C9ydVugg" name="BloodCells" mode="Physical" containerType="Compartment">
+                    <Container id="-WuEPhTZIUycjwSP04xTJw" name="BloodCells" mode="Physical" containerType="Compartment">
                       <Tags>
                         <Tag value="ColonDescendens" />
                         <Tag value="LargeIntestineSegment" />
                         <Tag value="Mucosa" />
                       </Tags>
                       <Children>
-                        <Parameter id="Qcvq5wDcsk-vb1LPdS8Gbg" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                        <Parameter id="ebPGLYCIG0aTgg-c5Jq0EQ" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
                           <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                         </Parameter>
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+                        <Parameter id="pDIO7cOh_kSc0lrmqQW9eQ" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_bc_2Pores" isDefault="1" displayUnit="l">
                           <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                           <Info min="0" flag="62" seq="119" ref="0" bb="2" group="121" />
                         </Parameter>
-                        <Container id="rxdsmM8opUuO36SVKzlxAQ" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                        <Container id="NcOKJf_i3U-A03BlkFSi8g" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                           <Children>
-                            <Parameter id="yjLLYSj6OEiDPMcRSeRZcw" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" isDefault="1">
-                              <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
-                            </Parameter>
-                            <Parameter id="tu_SioEim0OG9L7AmbLaSQ" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                            <Parameter id="603aIXXxAE6eYvuZDK9RlA" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                             </Parameter>
-                            <Parameter id="xPKzDAB03EqdPoh-W7ssCg" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                            <Parameter id="5vhUuuqdFEetoWEkb1e6cQ" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" isDefault="1">
+                              <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                            </Parameter>
+                            <Parameter id="eHaRc2647U6Pxc-MvEimPw" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
                               <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                             </Parameter>
                           </Children>
                         </Container>
                       </Children>
                     </Container>
-                    <Container id="3jiqFzHR_kGZUMfsY5YGdg" name="Interstitial" mode="Physical" containerType="Compartment">
+                    <Container id="zrgwuEAKdEmyWNT7C0WyVw" name="Interstitial" mode="Physical" containerType="Compartment">
                       <Tags>
                         <Tag value="ColonDescendens" />
                         <Tag value="LargeIntestineSegment" />
                         <Tag value="Mucosa" />
                       </Tags>
                       <Children>
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+                        <Parameter id="g2GJ2iW2nEG5wfVPRzqvuQ" name="FcRn concentration in container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.FcRn_in_Container_Interstitial" isDefault="1" displayUnit="µmol/l">
                           <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                           <Info flag="52" seq="1" ref="0" bb="2" group="25" />
                         </Parameter>
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+                        <Parameter id="xRnzg8AzdUaaTVH7rty9xQ" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
                           <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                         </Parameter>
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+                        <Parameter id="zoMvI1umNkiwK9BYRNMTlA" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_int_2Pores" isDefault="1" displayUnit="l">
                           <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                           <Info min="0" flag="62" seq="119" ref="0" bb="2" group="124" />
                         </Parameter>
-                        <Parameter id="q1ZSGtGxP0SQtijCYcSAzA" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_pH_INT" isDefault="1">
+                        <Parameter id="Z4uVlmnw5ECksUM2DRwZ6Q" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_pH_INT" isDefault="1">
                           <Tags>
                             <Tag value="ColonDescendens" />
                             <Tag value="LargeIntestineSegment" />
@@ -11347,26 +11406,26 @@
                           </Tags>
                           <Info min="0" max="14" flag="122" seq="359" ref="0" bb="32" group="84" />
                         </Parameter>
-                        <Container id="jfqJ_ECVY02puLoX27k9Og" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                        <Container id="QKJBeGBqpUa-CaXnUFR2BQ" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                           <Children>
-                            <Parameter id="TrfFXIfQCkOv5BMfSf73FQ" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_coldesc" isDefault="1">
-                              <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
-                            </Parameter>
-                            <Parameter id="QfyasGUDk0yZR7AeYvI1Ew" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
-                              <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                            <Parameter id="AqSrb0JhW0GaPKUwY_VA-Q" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Plasma_and_Interstitial" isDefault="1" displayUnit="µmol/l">
+                              <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                              <Info flag="52" seq="1" ref="0" bb="2" group="25" />
                             </Parameter>
-                            <Parameter id="XGALHvLD9EO6QEZ5cguVCA" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                            <Parameter id="3Qcj6gQj10WVpDFyLZidjQ" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                             </Parameter>
-                            <Parameter id="VKkl3BJWkk2-qNCtrQp3Vg" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Plasma_and_Interstitial" isDefault="1" displayUnit="µmol/l">
-                              <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-                              <Info flag="52" seq="1" ref="0" bb="2" group="25" />
+                            <Parameter id="gdyX_tnC902ShENuKSUIkg" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_coldesc" isDefault="1">
+                              <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                            </Parameter>
+                            <Parameter id="XGHtBrFq302N6nCVG-nD6Q" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                              <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                             </Parameter>
                           </Children>
                         </Container>
                       </Children>
                     </Container>
-                    <Container id="mKycGZxaxU-wbBAV1rukfw" name="Intracellular" mode="Physical" containerType="Compartment">
+                    <Container id="WRzvpRIMeE6obqJjnbY-sQ" name="Intracellular" mode="Physical" containerType="Compartment">
                       <Tags>
                         <Tag value="ColonDescendens" />
                         <Tag value="IntestinalSecretionSource" />
@@ -11374,14 +11433,14 @@
                         <Tag value="Mucosa" />
                       </Tags>
                       <Children>
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+                        <Parameter id="2CybInsTNkGx6tHiWDyiVQ" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" isDefault="1" displayUnit="l">
                           <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                         </Parameter>
-                        <Parameter id="wWk2NUNssU-AfR3w-34oRA" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_cell_2Pores" isDefault="1" displayUnit="l">
+                        <Parameter id="j250tj0WOUKPIcv8ai-swg" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_cell_2Pores" isDefault="1" displayUnit="l">
                           <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                           <Info min="0" flag="62" seq="119" ref="0" bb="2" group="125" />
                         </Parameter>
-                        <Parameter id="1-WcJaaDCkaxDaAZf93Jtw" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.3">
+                        <Parameter id="vNvbTqGpgESp5KevzaYTuw" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.3">
                           <Tags>
                             <Tag value="ColonDescendens" />
                             <Tag value="IntestinalSecretionSource" />
@@ -11391,296 +11450,296 @@
                           <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
                           <Info min="0" max="14" flag="122" seq="359" ref="0" bb="32" group="83" />
                         </Parameter>
-                        <Container id="sjr7HMuCkEG_b6FrwIEewQ" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                        <Container id="T-wybSHcnUKttrIzlDK2jQ" name="MoleculeProperties" mode="Logical" containerType="Molecule">
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+                            <Parameter id="BgEJQYraXUud3inh-5FroA" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_coldesc" isDefault="1">
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                         <Tag value="ColonDescendens" />
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+                        <Parameter id="qJWn7J3uWUuy8INIsl2WMQ" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
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                         </Parameter>
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+                            <Parameter id="Mdn5Wnr3OkGVk47o4WjK4A" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
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                           <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                           <Info min="0" flag="62" seq="120" ref="0" bb="2" group="121" />
                         </Parameter>
-                        <Container id="orCAHwCmv0KHVUlCxxpQFg" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                        <Container id="Nd8NMNmFx0yTYY3lfBDqKw" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                           <Children>
-                            <Parameter id="_5yPO0NPbE2bIIpF-wCm3g" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                            <Parameter id="Kv_9bcic2kWTGx0v8fenSw" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                             </Parameter>
-                            <Parameter id="8YKfGyxnt0Kl0OyrPrbgdQ" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" isDefault="1">
+                            <Parameter id="orrlZIk3CEqXj6h0xygf2A" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                             </Parameter>
-                            <Parameter id="9t4aIC_NJ0WN1hc8WxkTMA" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                            <Parameter id="s-b4YBx0wUyeA_Yd1dY9Cg" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
                               <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                             </Parameter>
                           </Children>
                         </Container>
                       </Children>
                     </Container>
-                    <Container id="d0rNGHjBGkStSpuA3K_WCw" name="Interstitial" mode="Physical" containerType="Compartment">
+                    <Container id="ezmOoZjgZ0G730YeQlQEHA" name="Interstitial" mode="Physical" containerType="Compartment">
                       <Tags>
                         <Tag value="ColonSigmoid" />
                         <Tag value="LargeIntestineSegment" />
                         <Tag value="Mucosa" />
                       </Tags>
                       <Children>
-                        <Parameter id="Q0_1_5FxgEetZVB2WAUJ6A" name="FcRn concentration in container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.FcRn_in_Container_Interstitial" isDefault="1" displayUnit="µmol/l">
+                        <Parameter id="c_Y3P0M9A0OiqGcpyz6dhw" name="FcRn concentration in container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.FcRn_in_Container_Interstitial" isDefault="1" displayUnit="µmol/l">
                           <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                           <Info flag="52" seq="1" ref="0" bb="2" group="25" />
                         </Parameter>
-                        <Parameter id="aXZ6Gvode027fegleeAIkg" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                        <Parameter id="BUFcykvpF02fgmHa_AIJBg" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
                           <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                         </Parameter>
-                        <Parameter id="HL6eng4iZUiPXxfkJg65hw" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_int_2Pores" isDefault="1" displayUnit="l">
+                        <Parameter id="xaoDYHeFw0iC8uNfk77wQw" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_int_2Pores" isDefault="1" displayUnit="l">
                           <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                           <Info min="0" flag="62" seq="120" ref="0" bb="2" group="124" />
                         </Parameter>
-                        <Parameter id="_wmiE4WgpkOPul7HKdqjLw" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_pH_INT" isDefault="1">
+                        <Parameter id="z7iDnfzuaEi0HAj6lr-JhA" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_pH_INT" isDefault="1">
                           <Tags>
                             <Tag value="ColonSigmoid" />
                             <Tag value="LargeIntestineSegment" />
@@ -11688,26 +11747,26 @@
                           </Tags>
                           <Info min="0" max="14" flag="122" seq="362" ref="0" bb="32" group="84" />
                         </Parameter>
-                        <Container id="Woh_n8TswEOsdPw6aus-9g" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                        <Container id="z3t_A1jquEGF644K0zTByA" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                           <Children>
-                            <Parameter id="okQGltazVEGUD4E1oZdohQ" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Plasma_and_Interstitial" isDefault="1" displayUnit="µmol/l">
+                            <Parameter id="TnpAvInf1kGSOGYEgRI4ig" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Plasma_and_Interstitial" isDefault="1" displayUnit="µmol/l">
                               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                               <Info flag="52" seq="1" ref="0" bb="2" group="25" />
                             </Parameter>
-                            <Parameter id="XwmcaMLf1E6YnCZcQpycMg" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                            <Parameter id="MEAUHuImrUme0W4xoylehA" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                             </Parameter>
-                            <Parameter id="jj3VD5Ow6UqtMBLOHKD0-g" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_colsigm" isDefault="1">
+                            <Parameter id="YFsm1CJXLU-yAlmJ4FdY5A" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_colsigm" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                             </Parameter>
-                            <Parameter id="37zXmiwdPk-Ln0nBaj_9_A" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                            <Parameter id="LXWWvSya10qGyAFVSxLfbg" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
                               <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                             </Parameter>
                           </Children>
                         </Container>
                       </Children>
                     </Container>
-                    <Container id="ECAR3iZfl0CtlZHp7S_zaQ" name="Intracellular" mode="Physical" containerType="Compartment">
+                    <Container id="XqUZ4UhE-EyE99zEOxxkNg" name="Intracellular" mode="Physical" containerType="Compartment">
                       <Tags>
                         <Tag value="ColonSigmoid" />
                         <Tag value="IntestinalSecretionSource" />
@@ -11715,14 +11774,14 @@
                         <Tag value="Mucosa" />
                       </Tags>
                       <Children>
-                        <Parameter id="RBUwXN1efESxP3pDPs6ZzA" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" isDefault="1" displayUnit="l">
+                        <Parameter id="z6UJIEf6gEisOZpP23daMQ" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" isDefault="1" displayUnit="l">
                           <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                         </Parameter>
-                        <Parameter id="T0ni-JcxAUCaW40KKvw6Zw" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_cell_2Pores" isDefault="1" displayUnit="l">
+                        <Parameter id="YshS_8pRK0qm3DRFZQC2fA" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_cell_2Pores" isDefault="1" displayUnit="l">
                           <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                           <Info min="0" flag="62" seq="120" ref="0" bb="2" group="125" />
                         </Parameter>
-                        <Parameter id="JYCF1g17oE-zb0VkJIFUYw" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.3">
+                        <Parameter id="VcndPVuAqkSnDFobCtEHOw" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.3">
                           <Tags>
                             <Tag value="ColonSigmoid" />
                             <Tag value="IntestinalSecretionSource" />
@@ -11732,296 +11791,296 @@
                           <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
                           <Info min="0" max="14" flag="122" seq="362" ref="0" bb="32" group="83" />
                         </Parameter>
-                        <Container id="KH84QSjH7EmV8SoMwXOt_g" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                        <Container id="Fg-0hWVyiEezs8zD9ehqIA" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                           <Children>
-                            <Parameter id="0B1hKn6iwU6e3PjG62RzEA" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                            <Parameter id="1AhM_fK76ECMIFtz0zoIfg" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                             </Parameter>
-                            <Parameter id="AWwlSon2UEGIqxIuFhkSqg" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_colsigm" isDefault="1">
+                            <Parameter id="YjSDiDzPek-9JhP0l42gPA" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_colsigm" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                             </Parameter>
-                            <Parameter id="dXa9CPSvP02bk5jwI9N-cg" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                            <Parameter id="4zTLzOF9i0yX9DuV7ZG1SA" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
                               <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                             </Parameter>
                           </Children>
                         </Container>
                       </Children>
                     </Container>
-                    <Container id="Z4c7wB5sl0K7_nqp7uDKWg" name="Endosome" mode="Physical" containerType="Compartment">
+                    <Container id="QAloCcgN-0iaMfqrp--wEQ" name="Endosome" mode="Physical" containerType="Compartment">
                       <Tags>
                         <Tag value="ColonSigmoid" />
                         <Tag value="LargeIntestineSegment" />
                         <Tag value="Mucosa" />
                       </Tags>
                       <Children>
-                        <Parameter id="Y8_QOyw76k6CLg-To4Y7lA" name="FcRn concentration in container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.FcRn_in_Container_Endosomal" isDefault="1" displayUnit="µmol/l">
+                        <Parameter id="i6zWeEBYjEyD0fmD7_SaMA" name="FcRn concentration in container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.FcRn_in_Container_Endosomal" isDefault="1" displayUnit="µmol/l">
                           <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                           <Info flag="52" seq="1" ref="0" bb="2" group="25" />
                         </Parameter>
-                        <Parameter id="RSVpMLiVcUC3KkzTItp7QA" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                        <Parameter id="LU4w9gh5hU2r6L6ZkRfO3Q" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
                           <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                         </Parameter>
-                        <Parameter id="iT9eF_Iz3USEXaeO2V9dPQ" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_end_colsigm" isDefault="1" displayUnit="l">
+                        <Parameter id="sqozpV1OGkKDPXUEQRM-WA" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_end_colsigm" isDefault="1" displayUnit="l">
                           <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                           <Info min="0" flag="122" seq="120" ref="0" bb="2" group="123" />
                         </Parameter>
-                        <Container id="zJwAeugrCkum8bbS2-arNw" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                        <Container id="jfSODxPVDEWl110Gld_LtQ" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                           <Children>
-                            <Parameter id="KPsG9L4sd0ecvl5TCKCIkQ" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                            <Parameter id="8G8xEFBWyUOukgMDsgRR3w" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Endosomal" isDefault="1" displayUnit="µmol/l">
                               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-                              <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
-                            </Parameter>
-                            <Parameter id="IakZJi-g-Uiv4VyNNUX9zQ" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
-                              <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                              <Info flag="52" seq="1" ref="0" bb="2" group="25" />
                             </Parameter>
-                            <Parameter id="YmsCP021zEm6ISScUd63BA" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                            <Parameter id="KyMNmvE2M0ei0FJOJho6Rg" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                             </Parameter>
-                            <Parameter id="NKZ2_Oo_jkirQs32pYuAbQ" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Endosomal" isDefault="1" displayUnit="µmol/l">
+                            <Parameter id="uuY3TSmi9UaqVa3fPONdbA" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
                               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-                              <Info flag="52" seq="1" ref="0" bb="2" group="25" />
+                              <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                            </Parameter>
+                            <Parameter id="TZn54coJcUefohVAY_2VoA" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                              <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                             </Parameter>
                           </Children>
                         </Container>
                       </Children>
                     </Container>
-                    <Container id="uoPPFi8Gj0-vu2OOlM3JnQ" name="MoleculeProperties" mode="Logical" containerType="Molecule" />
+                    <Container id="w03D-463_0GO9vJm7RFF4Q" name="MoleculeProperties" mode="Logical" containerType="Molecule" />
                   </Children>
                 </Container>
-                <Container id="fCUVLTKmHEmlx2cDYWxdvQ" name="Rectum" mode="Logical" containerType="Compartment">
+                <Container id="gGk3sUUL2EqQt0g-of14zA" name="Rectum" mode="Logical" containerType="Compartment">
                   <Children>
-                    <Parameter id="RqYjDKG4G0uKkYMH4ku0og" name="Fraction of endosomal uptake from plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_uptake_vas" isDefault="1">
+                    <Parameter id="sWGRGxDzJEuCcqTN0XFxXQ" name="Fraction of endosomal uptake from plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_uptake_vas" isDefault="1">
                       <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                       <Info min="0" flag="54" seq="0" ref="0" bb="2" group="25" />
                     </Parameter>
-                    <Parameter id="kLISJ19RWUiIxtj_Em4ucw" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
-                      <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
-                    </Parameter>
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+                    <Parameter id="1_W_TIgBg0aG8yLV01tmCw" name="Vf (water)-WS" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.78">
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+                    <Parameter id="WzAxPk8Hb0eAC-XGg4_7WQ" name="Acidic phospholipids [mg/g] - RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.41">
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+                    </Parameter>
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                         <Tag value="LargeIntestineSegment" />
                         <Tag value="Mucosa" />
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+                        <Parameter id="RV66nHdGEkSmgQPe3SslCw" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
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                           <Info min="0" flag="62" seq="121" ref="0" bb="2" group="126" />
                         </Parameter>
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+                        <Container id="70XIfWtrbUqiUfoScKbgTQ" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                           <Children>
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+                            <Parameter id="1q_VGbOX0UegzBTECbPqxw" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Plasma_and_Interstitial" isDefault="1" displayUnit="µmol/l">
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+                            <Parameter id="Q8XCf-t1KE2kWqajIrqi6A" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                             </Parameter>
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+                            <Parameter id="3eFwpx3VoEuMyuHvJnpihA" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                             </Parameter>
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+                            <Parameter id="BT2md0DsYUKyIKdr2mCMCQ" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
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-                    <Container id="p0bnHVbUckaxiZF-DyaNeg" name="BloodCells" mode="Physical" containerType="Compartment">
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                         <Tag value="LargeIntestineSegment" />
                         <Tag value="Mucosa" />
                         <Tag value="Rectum" />
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                           <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
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+                        <Parameter id="4Xy8C3hcc0KO0-2kKIbl5A" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_bc_2Pores" isDefault="1" displayUnit="l">
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                           <Info min="0" flag="62" seq="121" ref="0" bb="2" group="121" />
                         </Parameter>
-                        <Container id="f8x6wc7GgEKnLdutpoI0kg" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                        <Container id="yYJx5hQQ-kiGQMf2uDGhQQ" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                           <Children>
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-                              <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
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                             </Parameter>
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+                            <Parameter id="6rSVF4-C4EujvKsg-a8cAA" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                             </Parameter>
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-                              <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                            <Parameter id="hvS_O-YxHEetygzf4jaMdw" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                              <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
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-                    <Container id="jL0phy_0okq1f1ayx6hWMw" name="Interstitial" mode="Physical" containerType="Compartment">
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                         <Tag value="LargeIntestineSegment" />
                         <Tag value="Mucosa" />
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+                        <Parameter id="Tjibu10rq06mSxh7U81YqQ" name="FcRn concentration in container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.FcRn_in_Container_Interstitial" isDefault="1" displayUnit="µmol/l">
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                           <Info flag="52" seq="1" ref="0" bb="2" group="25" />
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+                        <Parameter id="jYNU9cPMcESfYl18r1TzsA" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
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+                        <Parameter id="cm6imjcLeUOSVZPy2yn7cA" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_int_2Pores" isDefault="1" displayUnit="l">
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                           <Info min="0" flag="62" seq="121" ref="0" bb="2" group="124" />
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-                        <Parameter id="mvhjilacO06Ex4vIbAB73g" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_pH_INT" isDefault="1">
+                        <Parameter id="3R_9WUsBDkeoIPTBcTkv7w" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_pH_INT" isDefault="1">
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@@ -12029,26 +12088,26 @@
                           </Tags>
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                         </Parameter>
-                        <Container id="eruFROc1RUq98sVP8CZJhA" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                        <Container id="sPG8Mz3SvUeN7sjnV4AuLA" name="MoleculeProperties" mode="Logical" containerType="Molecule">
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-                              <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                            <Parameter id="S14i8PeHx0O46L15LCXoXw" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Plasma_and_Interstitial" isDefault="1" displayUnit="µmol/l">
+                              <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
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                             </Parameter>
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+                            <Parameter id="HLoVnCaf4kuRC0UJTBuZMA" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                             </Parameter>
-                            <Parameter id="8s2gF3ChQUmkkCqj2iejvg" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
-                              <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                            <Parameter id="YktD-FnyGUigMmByyoxJnA" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_rect" isDefault="1">
+                              <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                             </Parameter>
-                            <Parameter id="njb7pPzZd0CLZl6iHlQ0sA" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Plasma_and_Interstitial" isDefault="1" displayUnit="µmol/l">
-                              <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-                              <Info flag="52" seq="1" ref="0" bb="2" group="25" />
+                            <Parameter id="DeXqkuDqsEiPZ72Y5hp6rQ" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                              <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                             </Parameter>
                           </Children>
                         </Container>
                       </Children>
                     </Container>
-                    <Container id="TOYzThEJtkuhn2I6SIg6tA" name="Intracellular" mode="Physical" containerType="Compartment">
+                    <Container id="KYsx3k5GgUu-J_d7og6DPQ" name="Intracellular" mode="Physical" containerType="Compartment">
                       <Tags>
                         <Tag value="IntestinalSecretionSource" />
                         <Tag value="LargeIntestineSegment" />
@@ -12056,14 +12115,14 @@
                         <Tag value="Rectum" />
                       </Tags>
                       <Children>
-                        <Parameter id="XcN-PnfAeUa2OaGoBFl8fw" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" isDefault="1" displayUnit="l">
+                        <Parameter id="qy3zNnfmc02QVTWPduPNjQ" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" isDefault="1" displayUnit="l">
                           <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                         </Parameter>
-                        <Parameter id="3JWO294__kmZXuXXcqxuRg" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_cell_2Pores" isDefault="1" displayUnit="l">
+                        <Parameter id="pan0CUu0cUuvvErz1iMWRg" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_cell_2Pores" isDefault="1" displayUnit="l">
                           <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                           <Info min="0" flag="62" seq="121" ref="0" bb="2" group="125" />
                         </Parameter>
-                        <Parameter id="Ct6C1zMf70-b9OvDD-hsfA" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.3">
+                        <Parameter id="xxUSxg1_4E-rbbVJiiarYA" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.3">
                           <Tags>
                             <Tag value="IntestinalSecretionSource" />
                             <Tag value="LargeIntestineSegment" />
@@ -12073,1116 +12132,1118 @@
                           <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
                           <Info min="0" max="14" flag="122" seq="365" ref="0" bb="32" group="83" />
                         </Parameter>
-                        <Container id="a0sbPYVPFEqKCU0fv09tzQ" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                        <Container id="BdUaeUrkF0qnTOFi3nygRw" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                           <Children>
-                            <Parameter id="misEmI6fPEu4MQ1nxsoTew" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                            <Parameter id="g-ihbg34JUiaGDsi9fuj9g" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                             </Parameter>
-                            <Parameter id="nOHfDZ9saESGNvDQrxROzw" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_rect" isDefault="1">
+                            <Parameter id="ebUG0r6xMUONhPk0_aua5Q" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_rect" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                             </Parameter>
-                            <Parameter id="b7guK1cfmU2oX2ouaB8Crg" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                            <Parameter id="esZfbpHGskSqA4Xrysdeqw" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
                               <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                             </Parameter>
                           </Children>
                         </Container>
                       </Children>
                     </Container>
-                    <Container id="sDh-svYJyEKCjXiZQWry0A" name="Endosome" mode="Physical" containerType="Compartment">
+                    <Container id="dgS26q3Pd0iorPNFEOfBEg" name="Endosome" mode="Physical" containerType="Compartment">
                       <Tags>
                         <Tag value="LargeIntestineSegment" />
                         <Tag value="Mucosa" />
                         <Tag value="Rectum" />
                       </Tags>
                       <Children>
-                        <Parameter id="u3KpueAfSk-8vbGoiu51VA" name="FcRn concentration in container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.FcRn_in_Container_Endosomal" isDefault="1" displayUnit="µmol/l">
+                        <Parameter id="4uTmsjapUUmp98_pCfVcUw" name="FcRn concentration in container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.FcRn_in_Container_Endosomal" isDefault="1" displayUnit="µmol/l">
                           <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                           <Info flag="52" seq="1" ref="0" bb="2" group="25" />
                         </Parameter>
-                        <Parameter id="-Id9NtzKH0CM6G7cD9O_Kg" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                        <Parameter id="vQJjzBZOykCL2vroJLTcqQ" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
                           <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                         </Parameter>
-                        <Parameter id="9jgQP5dmwU-KGsrNWtYSYg" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_end_rect" isDefault="1" displayUnit="l">
+                        <Parameter id="nCiyEZfqpE2LXbnrVL0ZEg" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_end_rect" isDefault="1" displayUnit="l">
                           <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                           <Info min="0" flag="122" seq="121" ref="0" bb="2" group="123" />
                         </Parameter>
-                        <Container id="z_ExiUroUUGzELafFY3qBQ" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                        <Container id="aGoOM6vE20apcg_cH1zy8A" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                           <Children>
-                            <Parameter id="SECPkPkzk0qL2J10ycS0tg" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Endosomal" isDefault="1" displayUnit="µmol/l">
+                            <Parameter id="G9H1wFldzUWv7Ict1Q92tA" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Endosomal" isDefault="1" displayUnit="µmol/l">
                               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                               <Info flag="52" seq="1" ref="0" bb="2" group="25" />
                             </Parameter>
-                            <Parameter id="16HvRXNjYEiIW2lkFIEYrA" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                            <Parameter id="tnnrtH5zuUON3_dytICG4w" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                             </Parameter>
-                            <Parameter id="HokHHoNar066p21Ca1ymdQ" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
-                              <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
-                            </Parameter>
-                            <Parameter id="VBd-WTUIHUGXfIuRl1af1Q" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                            <Parameter id="gxRml9IFL0qlryqgF-cYMw" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
                               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                             </Parameter>
+                            <Parameter id="SVNEz-c6N0igB2tL-0C44w" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                              <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                            </Parameter>
                           </Children>
                         </Container>
                       </Children>
                     </Container>
-                    <Container id="VDF2X9pqiUmV81Q_goWu8Q" name="MoleculeProperties" mode="Logical" containerType="Molecule" />
+                    <Container id="wYIzsuwIEku7nwVK5Kyt2A" name="MoleculeProperties" mode="Logical" containerType="Molecule" />
                   </Children>
                 </Container>
               </Children>
             </Container>
           </Children>
         </Container>
-        <Container id="xS-ckNxAukGINIgsZ5ixgg" name="Liver" mode="Logical" containerType="Organ">
+        <Container id="N2M5V6c5YEKCPcIBs6KKxg" name="Liver" mode="Logical" containerType="Organ">
           <Children>
-            <Parameter id="uLbxrQ0aSkafgd0aVkTH2A" name="Fraction of endosomal uptake from plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_uptake_vas" isDefault="1">
+            <Parameter id="Kyu8hoKQZkaRwI4qbndc9g" name="Fraction of endosomal uptake from plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_uptake_vas" isDefault="1">
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
               <Info min="0" flag="54" seq="0" ref="0" bb="2" group="25" />
             </Parameter>
-            <Parameter id="G4_i3Al0bkezR9K8z_zj9w" name="Fraction endosomal" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_endo" isDefault="1">
+            <Parameter id="cdoe0sEOAUuMdIb3ngKaJw" name="Fraction endosomal" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_endo" isDefault="1">
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
               <Info min="0" max="1" flag="54" seq="1" ref="0" bb="2" group="29" />
             </Parameter>
-            <Parameter id="w-omNjqBVUW-_c8jXQ4DTQ" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
-              <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
-            </Parameter>
-            <Parameter id="v0ziqFvzMUC1xNPESKmPIA" name="Rate constant for recycling from endosomal space" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_K_rec" isDefault="1" displayUnit="1/min">
+            <Parameter id="AqHMdcG3FU6_VbMDresYaA" name="Fraction recycled to plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_rec_vas" isDefault="1">
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
               <Info min="0" flag="54" seq="1" ref="0" bb="2" group="25" />
             </Parameter>
-            <Parameter id="CrESOea_00ylETmzwuPGbQ" name="Rate constant for endosomal uptake" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_K_uptake" isDefault="1" displayUnit="1/min">
+            <Parameter id="AlFQxNAhn0S-I3zwreF2ow" name="Rate constant for endosomal uptake" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_K_uptake" isDefault="1" displayUnit="1/min">
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
               <Info min="0" flag="54" seq="1" ref="0" bb="2" group="25" />
             </Parameter>
-            <Parameter id="CnmW5h0eEkmUgSgs8qo-TQ" name="Fraction recycled to plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_rec_vas" isDefault="1">
+            <Parameter id="Rfl9qDp4m0CrsOKqOzgcUA" name="Rate constant for recycling from endosomal space" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_K_rec" isDefault="1" displayUnit="1/min">
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
               <Info min="0" flag="54" seq="1" ref="0" bb="2" group="25" />
             </Parameter>
-            <Parameter id="JIEL8qvn2kaueOA6LbLePg" name="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Lymph_flow_rate" isDefault="1" displayUnit="l/min">
+            <Parameter id="ok9lMt00oUa9tNGmIkwa-g" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
+              <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
+            </Parameter>
+            <Parameter id="i2tVN1OFF0WU2vWYZtWimg" name="Fluid recirculation flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate" isDefault="1" displayUnit="l/min">
+              <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+              <Info min="0" flag="122" seq="17" ref="0" bb="32" group="27" />
+            </Parameter>
+            <Parameter id="c1XGF-v_D0uNQ_rppE-ukA" name="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Lymph_flow_rate" isDefault="1" displayUnit="l/min">
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
               <Info min="0" flag="122" seq="17" ref="0" bb="32" group="58" />
             </Parameter>
-            <Parameter id="muMmUHfeakuk9m3V4_VCMA" name="Volume (endothelium)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="VascularEndoVolume.VOLUME_VascularEndo_liv" isDefault="1" displayUnit="l">
+            <Parameter id="-_E3uhefF0G8De2kAdgTbw" name="Volume (endothelium)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="VascularEndoVolume.VOLUME_VascularEndo_liv" isDefault="1" displayUnit="l">
               <Info min="0" flag="62" seq="17" ref="0" bb="32" group="127" />
             </Parameter>
-            <Parameter id="JaXcg409iE6X4VQ-MV0-yA" name="Fluid recirculation flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate" isDefault="1" displayUnit="l/min">
-              <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-              <Info min="0" flag="122" seq="17" ref="0" bb="32" group="27" />
+            <Parameter id="t5D-lGTMeEGgDjz_yViL6Q" name="Fraction intracellular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_f_cell" isDefault="1">
+              <Info min="0" max="1" flag="62" seq="54" ref="0" bb="32" group="64" />
             </Parameter>
-            <Parameter id="0A3_TtseG0Om7WpvitRiQA" name="Is liver zonated" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0">
+            <Parameter id="i4jWCR10VEyUfFxMcckvoA" name="Is liver zonated" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0">
               <Info min="0" max="1" flag="58" seq="54" ref="0" bb="32" group="149" />
             </Parameter>
-            <Parameter id="JI7j1hDkFkeV1IXEuaRgZA" name="Fraction intracellular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_f_cell" isDefault="1">
-              <Info min="0" max="1" flag="62" seq="54" ref="0" bb="32" group="64" />
-            </Parameter>
-            <Parameter id="SM6k4oD4q0Gxxv8jbpdZtA" name="Fraction of periportal zone" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5" displayUnit="%">
+            <Parameter id="ZETqt9WqOUKwzqdayS8ggw" name="Fraction of periportal zone" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5" displayUnit="%">
               <Info min="0" max="1" flag="74" seq="55" ref="0" bb="32" group="149" />
             </Parameter>
-            <Parameter id="9TNRpJbuik2DGuVWOorGDg" name="Blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_from_Qspec" isDefault="1" displayUnit="l/min">
-              <ValueOrigin id="48" description="TODO: Absolute from specific calculation" />
+            <Parameter id="OyBrmOX4hU21QvlggVWCsQ" name="Blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_from_Qspec" isDefault="1" displayUnit="l/min">
+              <ValueOrigin id="48" source="Other" description="Absolute value = specific value (i.e. value normalized to the volume of the organ) multiplied by the organ volume" />
               <Info min="0" flag="62" seq="142" ref="0" bb="32" group="5" />
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+                <Parameter id="O5StJVEn7EurYBoxECCECw" name="Allometric scale factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Allometric scale factor_LiverZone" isDefault="1">
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+                <Parameter id="CxSKOfOnd0Wx5gSdXLLMHQ" name="Flow fraction via large pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Flow fraction via large pores_LiverZone" isDefault="1">
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+                <Parameter id="cAea0p_WWUmO4OSEHg10Ew" name="Fluid recirculation flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate_Liver_Periportal" isDefault="1" displayUnit="l/min">
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+                <Parameter id="gzsaTTCryE-tQMaqJ9QMIQ" name="Hydraulic conductivity" icon="Parameter" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Hydraulic conductivity_LiverZone" isDefault="1" displayUnit="ml/min/N">
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+                <Parameter id="FShtDYCY_UCeu52x8nFvyg" name="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Lymph_flow_rate_Liver_Periportal" isDefault="1" displayUnit="l/min">
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+                <Parameter id="OqfbTA_w5061LUH0E0qAjw" name="Volume (endothelium)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="VascularEndoVolume.VOLUME_VascularEndo_liv_periportal" isDefault="1" displayUnit="l">
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                 </Parameter>
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+                <Parameter id="1xb80P0sK0qYF9FhwfmTfA" name="Albumin ratio (tissue/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Albumin ratio (tissue/plasma)_LiverZone" isDefault="1">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
                   <Info min="0" max="1" flag="54" seq="53" ref="0" bb="32" group="111" />
                 </Parameter>
-                <Parameter id="941dkKZJq0OqbolkBpBAOg" name="Lipoprotein ratio (tissue/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Lipoprotein ratio (tissue/plasma)_LiverZone" isDefault="1">
+                <Parameter id="34AZLIMBs0-BSG-nIOk6Wg" name="Albumin ratio (tissue/plasma)-PT" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Albumin ratio (tissue/plasma)-PT_LiverZone" isDefault="1">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
-                  <Info min="0" max="1" flag="54" seq="53" ref="0" bb="32" group="113" />
+                  <Info min="0" max="1" flag="54" seq="53" ref="0" bb="32" group="112" />
                 </Parameter>
-                <Parameter id="h9C317cgzEKnD-_fxBmDog" name="Vf (water)-PT" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (water)-PT_LiverZone" isDefault="1">
+                <Parameter id="0yReDIA3jUOvMysC8bGrag" name="Fraction vascular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Fraction vascular_LiverZone" isDefault="1">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
-                  <Info min="0" max="1" flag="54" seq="53" ref="0" bb="32" group="86" />
+                  <Info min="0" max="1" flag="54" seq="53" ref="0" bb="32" group="64" />
                 </Parameter>
-                <Parameter id="xOdCONyZsUqyPcwKMR9n8Q" name="Number of cells/g tissue" icon="Parameter" persistable="0" isFixedValue="0" dim="Count per mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Number of cells/g tissue_LiverZone" isDefault="1" displayUnit="x10^6/g">
+                <Parameter id="bXhax8K-6UGayujEYoIAOA" name="Lipoprotein ratio (tissue/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Lipoprotein ratio (tissue/plasma)_LiverZone" isDefault="1">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
-                  <Info min="0" max="1000000" flag="54" seq="53" ref="0" bb="32" group="61" />
+                  <Info min="0" max="1" flag="54" seq="53" ref="0" bb="32" group="113" />
                 </Parameter>
-                <Parameter id="jQZxP2nUbkOf8u3CuK9Bcg" name="Microsomal protein mass/g tissue" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass per tissue" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Microsomal protein mass/g tissue_LiverZone" isDefault="1" displayUnit="mg/g">
+                <Parameter id="EguAZPB6XUaiS1geA2p8Ig" name="Microsomal protein mass/g tissue" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass per tissue" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Microsomal protein mass/g tissue_LiverZone" isDefault="1" displayUnit="mg/g">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
                   <Info min="0" max="1" flag="54" seq="53" ref="0" bb="32" group="59" />
                 </Parameter>
-                <Parameter id="L_urE0Fb70i0AebeabeVdg" name="Albumin ratio (tissue/plasma)-PT" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Albumin ratio (tissue/plasma)-PT_LiverZone" isDefault="1">
+                <Parameter id="X-AXEotgxEqfBQvnz_J-mA" name="Number of cells/g tissue" icon="Parameter" persistable="0" isFixedValue="0" dim="Count per mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Number of cells/g tissue_LiverZone" isDefault="1" displayUnit="x10^6/g">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
-                  <Info min="0" max="1" flag="54" seq="53" ref="0" bb="32" group="112" />
+                  <Info min="0" max="1000000" flag="54" seq="53" ref="0" bb="32" group="61" />
                 </Parameter>
-                <Parameter id="r6xmRhyNsE-569eHQOoCyQ" name="Fraction vascular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Fraction vascular_LiverZone" isDefault="1">
+                <Parameter id="6VTEqjKx5Eq0aZOoY1DAEQ" name="Vf (water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (water)_LiverZone" isDefault="1">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
-                  <Info min="0" max="1" flag="54" seq="53" ref="0" bb="32" group="64" />
+                  <Info min="0" max="1" flag="54" seq="53" ref="0" bb="32" group="85" />
                 </Parameter>
-                <Parameter id="yVRm1Cibrkq2ZxfBQc-x_w" name="Vf (water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (water)_LiverZone" isDefault="1">
+                <Parameter id="yghoCMD45EKQdJh_S4ucyA" name="Vf (water)-PT" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (water)-PT_LiverZone" isDefault="1">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
-                  <Info min="0" max="1" flag="54" seq="53" ref="0" bb="32" group="85" />
+                  <Info min="0" max="1" flag="54" seq="53" ref="0" bb="32" group="86" />
                 </Parameter>
-                <Parameter id="g0XC5MepS06wZXLx0GJfdA" name="Fraction intracellular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_f_cell_LiverZone" isDefault="1">
+                <Parameter id="VqRE3oAu5kaOKXfV4j-alQ" name="Fraction intracellular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_f_cell_LiverZone" isDefault="1">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
                   <Info min="0" max="1" flag="54" seq="56" ref="0" bb="32" group="64" />
                 </Parameter>
-                <Parameter id="5oUu6KghQ0yB52t31sZHSw" name="Fraction interstitial" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Fraction interstitial_LiverZone" isDefault="1">
+                <Parameter id="Rt60uFdFTUOE0bDEAwvvgg" name="Fraction interstitial" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Fraction interstitial_LiverZone" isDefault="1">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
                   <Info min="0" max="1" flag="54" seq="59" ref="0" bb="32" group="64" />
                 </Parameter>
-                <Parameter id="qKZVgpPPH0KSmfPV0buJoA" name="Vf (neutral lipid)-RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (neutral lipid)-RR_LiverZone" isDefault="1">
+                <Parameter id="KJF3Sga3WUeyuMjCYfkpwQ" name="Vf (neutral lipid)-RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (neutral lipid)-RR_LiverZone" isDefault="1">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
                   <Info min="0" max="1" flag="54" seq="85" ref="0" bb="32" group="92" />
                 </Parameter>
-                <Parameter id="mj7P3adEN0ievaBnOqZtdQ" name="Vf (neutral lipid)-WS" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (neutral lipid)-WS_LiverZone" isDefault="1">
+                <Parameter id="K-JVSU5Ko0O2SCoV0Wg2Fg" name="Vf (neutral lipid)-WS" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (neutral lipid)-WS_LiverZone" isDefault="1">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
                   <Info min="0" max="1" flag="54" seq="85" ref="0" bb="32" group="95" />
                 </Parameter>
-                <Parameter id="AIuaoqIUtUK4dx8mKvkPfQ" name="Vf (neutral phospholipid)-RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (neutral phospholipid)-RR_LiverZone" isDefault="1">
+                <Parameter id="aytFQRS8NECWxI2npPlTyg" name="Vf (neutral phospholipid)-RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (neutral phospholipid)-RR_LiverZone" isDefault="1">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
                   <Info min="0" max="1" flag="54" seq="86" ref="0" bb="32" group="92" />
                 </Parameter>
-                <Parameter id="_IfWB9WBTECMn75ZvUdFxQ" name="Vf (neutral phospholipid, plasma)-WS" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (neutral phospholipid, plasma)-WS_LiverZone" isDefault="1">
+                <Parameter id="nYio5Z2odEu1kUYqM7Xazg" name="Vf (neutral phospholipid, plasma)-WS" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (neutral phospholipid, plasma)-WS_LiverZone" isDefault="1">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
                   <Info min="0" max="1" flag="54" seq="86" ref="0" bb="32" group="95" />
                 </Parameter>
-                <Parameter id="GjsYTnE_t0ia4hP1VoSsCA" name="Vf (protein)-WS" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (protein)-WS_LiverZone" isDefault="1">
+                <Parameter id="1L-Z-3gFhki0BiCGx_pJxg" name="Vf (extracellular water)-RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (extracellular water)-RR_LiverZone" isDefault="1">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
-                  <Info min="0" max="1" flag="54" seq="87" ref="0" bb="32" group="95" />
+                  <Info min="0" max="1" flag="54" seq="87" ref="0" bb="32" group="92" />
                 </Parameter>
-                <Parameter id="PW_IaoCEIUCuaUrgVLuasw" name="Vf (extracellular water)-RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (extracellular water)-RR_LiverZone" isDefault="1">
+                <Parameter id="_ZyQjcJjnEWiqi4P8B3pCQ" name="Vf (protein)-WS" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (protein)-WS_LiverZone" isDefault="1">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
-                  <Info min="0" max="1" flag="54" seq="87" ref="0" bb="32" group="92" />
+                  <Info min="0" max="1" flag="54" seq="87" ref="0" bb="32" group="95" />
                 </Parameter>
-                <Parameter id="QF11vwhzUkW7eVwsp6EdpQ" name="Vf (water)-WS" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (water)-WS_LiverZone" isDefault="1">
+                <Parameter id="sa2lYG8QKEaCZvpkSfz3gA" name="Vf (intracellular water)-RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (intracellular water)-RR_LiverZone" isDefault="1">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
-                  <Info min="0" max="1" flag="54" seq="88" ref="0" bb="32" group="95" />
+                  <Info min="0" max="1" flag="54" seq="88" ref="0" bb="32" group="92" />
                 </Parameter>
-                <Parameter id="LG3tfTQlE0qjMn7iHE7P4Q" name="Vf (intracellular water)-RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (intracellular water)-RR_LiverZone" isDefault="1">
+                <Parameter id="0GPvjdtWH0uwm83bSUr2Ww" name="Vf (water)-WS" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (water)-WS_LiverZone" isDefault="1">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
-                  <Info min="0" max="1" flag="54" seq="88" ref="0" bb="32" group="92" />
+                  <Info min="0" max="1" flag="54" seq="88" ref="0" bb="32" group="95" />
                 </Parameter>
-                <Parameter id="Wua7UPxh70G4dDyKEOAQ5Q" name="Acidic phospholipids [mg/g] - RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Acidic phospholipids [mg/g] - RR_LiverZone" isDefault="1">
+                <Parameter id="sgGZUajAuEKw-WRkyqC-8Q" name="Acidic phospholipids [mg/g] - RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Acidic phospholipids [mg/g] - RR_LiverZone" isDefault="1">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
                   <Info min="0" max="1000" flag="54" seq="89" ref="0" bb="32" group="92" />
                 </Parameter>
-                <Parameter id="zZU-VnViIE6a2RJffgA15A" name="Vf (acidic phospholipids)-WS" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (acidic phospholipids)-WS_LiverZone" isDefault="1">
+                <Parameter id="2rkKxbCxAUmW-qc5dX19Xw" name="Vf (acidic phospholipids)-WS" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (acidic phospholipids)-WS_LiverZone" isDefault="1">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
                   <Info min="0" max="1" flag="54" seq="89" ref="0" bb="32" group="95" />
                 </Parameter>
-                <Parameter id="YiNp-SX5vU-TYAoAVZX3Vw" name="Specific blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Specific blood flow rate_LiverZone" isDefault="1" displayUnit="ml/min/100g organ">
+                <Parameter id="6i9ykzWs20eZ52oywAMz4A" name="Specific blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Specific blood flow rate_LiverZone" isDefault="1" displayUnit="ml/min/100g organ">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
                   <Info min="0" flag="54" seq="141" ref="0" bb="32" group="5" />
                 </Parameter>
-                <Parameter id="mKBkrrgmmk-k8egbu9c-vg" name="Blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_from_Qspec_LiverZone" isDefault="1" displayUnit="l/min">
+                <Parameter id="ybKOd7v7V0uangGvnrOz_A" name="Blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_from_Qspec_LiverZone" isDefault="1" displayUnit="l/min">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
                   <Info min="0" flag="54" seq="142" ref="0" bb="32" group="5" />
                 </Parameter>
-                <Container id="8DZXItaWrkqNKYuUKQ9tjQ" name="Plasma" mode="Physical" containerType="Compartment">
+                <Container id="TOpTLsUGc0ma-rRDNQkZfw" name="Plasma" mode="Physical" containerType="Compartment">
                   <Tags>
                     <Tag value="Liver" />
                     <Tag value="Periportal" />
                   </Tags>
                   <Children>
-                    <Parameter id="pwJs5FO-SU6NUTccrRyRzg" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
-                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
-                    </Parameter>
-                    <Parameter id="pDFqKlnc9EqA7ItLejMpdw" name="FcRn concentration in container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.FcRn_in_Container_Plasma" isDefault="1" displayUnit="µmol/l">
+                    <Parameter id="ZIwEpooMuESFyTpsVsVkiA" name="FcRn concentration in container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.FcRn_in_Container_Plasma" isDefault="1" displayUnit="µmol/l">
                       <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                       <Info flag="52" seq="1" ref="0" bb="2" group="25" />
                     </Parameter>
-                    <Parameter id="7WmYoSeTdEa6449YZXr3vQ" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_pls_2Pores" isDefault="1" displayUnit="l">
+                    <Parameter id="q5lCtXBAHka4uUJBy-MGAA" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                    </Parameter>
+                    <Parameter id="O_uoh7-HG0KNaO6Ix3m5uw" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_pls_2Pores" isDefault="1" displayUnit="l">
                       <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                       <Info min="0" flag="62" seq="17" ref="0" bb="2" group="126" />
                     </Parameter>
-                    <Container id="9-f7L-C6oUWON0E0ZqTqgg" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                    <Container id="HYSe_xieakGte65PO3OFFg" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                       <Children>
-                        <Parameter id="EdpdqpGwJ0CJZ2cbXbTD-w" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Plasma_and_Interstitial" isDefault="1" displayUnit="µmol/l">
+                        <Parameter id="GQhOUJ1qqk-XXYhzLDgXyw" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Plasma_and_Interstitial" isDefault="1" displayUnit="µmol/l">
                           <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                           <Info flag="52" seq="1" ref="0" bb="2" group="25" />
                         </Parameter>
-                        <Parameter id="wq6roZFaPEapjp68awm6ig" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                        <Parameter id="_nX682EpYUy0o3VG2Z3Zig" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                           <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                         </Parameter>
-                        <Parameter id="CVj02YEcDUyGnzqlbLXPMA" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" isDefault="1">
+                        <Parameter id="XryoHWjynE-91E5xX9raDA" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" isDefault="1">
                           <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                         </Parameter>
-                        <Parameter id="bIwxH5z15E-om5fWyfCw_A" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
+                        <Parameter id="2cCaPLmPVkStB_nmGGl4ew" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
                           <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                         </Parameter>
                       </Children>
                     </Container>
                   </Children>
                 </Container>
-                <Container id="c0pnnkb11EiaOMW4lLDk1A" name="BloodCells" mode="Physical" containerType="Compartment">
+                <Container id="psUhzcaPd0urxU07IkelGQ" name="BloodCells" mode="Physical" containerType="Compartment">
                   <Tags>
                     <Tag value="Liver" />
                     <Tag value="Periportal" />
                   </Tags>
                   <Children>
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+                    <Parameter id="gheQw6kBjEWwxPru4ijNPA" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
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+                <Parameter id="dFyNVFV1rE67v8qYB246Eg" name="Allometric scale factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Allometric scale factor_LiverZone" isDefault="1">
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                 </Parameter>
-                <Parameter id="_ehASwEEg0OvN2c1KgX83g" name="Density (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Density (tissue)_LiverZone" isDefault="1" displayUnit="g/cm³">
+                <Parameter id="Z5Y7vFWiu0KGU5LxpHyKLw" name="Density (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Density (tissue)_LiverZone" isDefault="1" displayUnit="g/cm³">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
                   <Info min="0" flag="38" seq="1" ref="0" bb="32" group="21" />
                 </Parameter>
-                <Parameter id="tmwZhYzHdUq_cd5K4glg2g" name="Fraction endosomal" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_endo_LiverZone" isDefault="1">
+                <Parameter id="TS70D9ZRc0usWT5jBZ2r4Q" name="Fraction endosomal" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_endo_LiverZone" isDefault="1">
                   <Info min="0" max="1" flag="54" seq="1" ref="0" bb="2" group="29" />
                 </Parameter>
-                <Parameter id="tmcSPjCzcE2-em1S0o3Knw" name="Fraction of blood for sampling" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Fraction of blood for sampling_LiverZone" isDefault="1">
+                <Parameter id="RiftcQZqFUKbrv9WDjDYSQ" name="Fraction of blood for sampling" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Fraction of blood for sampling_LiverZone" isDefault="1">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
                   <Info min="0" max="1" flag="54" seq="1" ref="0" bb="32" group="94" />
                 </Parameter>
-                <Parameter id="qR47FxGs_kyJQnShL4Jwiw" name="Fraction recycled to plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_rec_vas_LiverZone" isDefault="1">
+                <Parameter id="o91kR1SR5Uig3jgWOZTbTw" name="Fraction recycled to plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_rec_vas_LiverZone" isDefault="1">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="25" />
                 </Parameter>
-                <Parameter id="V72QE5u92EehqhF17W7dEQ" name="Rate constant for endosomal uptake" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_K_uptake_LiverZone" isDefault="1" displayUnit="1/min">
+                <Parameter id="brwfQPIP60O-Owb1HD8q9g" name="Rate constant for endosomal uptake" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_K_uptake_LiverZone" isDefault="1" displayUnit="1/min">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="25" />
                 </Parameter>
-                <Parameter id="VZNbaxK1AkuOOQd2JohccA" name="Rate constant for recycling from endosomal space" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_K_rec_LiverZone" isDefault="1" displayUnit="1/min">
+                <Parameter id="ta3mEF8STEqYnW-PLftLEg" name="Rate constant for recycling from endosomal space" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_K_rec_LiverZone" isDefault="1" displayUnit="1/min">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="25" />
                 </Parameter>
-                <Parameter id="BpciD6T0q0Gdg00oW2Ar5A" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
+                <Parameter id="ZvKO_AsQjU6lP2ey3md2mA" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
                   <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
                 </Parameter>
-                <Parameter id="c2hLjJfDb0-uSKwtW3NDHg" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Volume_Pericentral" isDefault="1" displayUnit="l">
+                <Parameter id="KOS3OCLYKEi4CYsLQZ6xcw" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Volume_Pericentral" isDefault="1" displayUnit="l">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
                   <Info min="0" flag="62" seq="10" ref="0" bb="32" group="65" />
                 </Parameter>
-                <Parameter id="D2Qfg9A2HEuV5Eq0Fvjh2A" name="Radius (small pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Radius (small pores)_LiverZone" isDefault="1" displayUnit="µm">
+                <Parameter id="fbC1kgMcyUuwD46c0yDQ5Q" name="Flow fraction via large pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Flow fraction via large pores_LiverZone" isDefault="1">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
-                  <Info min="0" flag="54" seq="17" ref="0" bb="32" group="99" />
+                  <Info min="0" max="1" flag="54" seq="17" ref="0" bb="32" group="114" />
                 </Parameter>
-                <Parameter id="mmwwNSiCMUmySX-icwiotw" name="Flow fraction via large pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Flow fraction via large pores_LiverZone" isDefault="1">
+                <Parameter id="WrQh1tlvrkWHyJ97qukfXA" name="Hydraulic conductivity" icon="Parameter" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Hydraulic conductivity_LiverZone" isDefault="1" displayUnit="ml/min/N">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
-                  <Info min="0" max="1" flag="54" seq="17" ref="0" bb="32" group="114" />
+                  <Info min="0" flag="54" seq="17" ref="0" bb="32" group="115" />
                 </Parameter>
-                <Parameter id="EEbZX1wLAkecjgiWvw-FqA" name="Hydraulic conductivity" icon="Parameter" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Hydraulic conductivity_LiverZone" isDefault="1" displayUnit="ml/min/N">
+                <Parameter id="ZUMyTKwbnUOV3202-eIvoA" name="Radius (large pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Radius (large pores)_LiverZone" isDefault="1" displayUnit="µm">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
-                  <Info min="0" flag="54" seq="17" ref="0" bb="32" group="115" />
+                  <Info min="0" flag="54" seq="17" ref="0" bb="32" group="55" />
                 </Parameter>
-                <Parameter id="jbLr6LAunUSPl36oaxc8tg" name="Radius (large pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Radius (large pores)_LiverZone" isDefault="1" displayUnit="µm">
+                <Parameter id="54fbU9r-eUeiAoyx1zKF9Q" name="Radius (small pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Radius (small pores)_LiverZone" isDefault="1" displayUnit="µm">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
-                  <Info min="0" flag="54" seq="17" ref="0" bb="32" group="55" />
+                  <Info min="0" flag="54" seq="17" ref="0" bb="32" group="99" />
                 </Parameter>
-                <Parameter id="40Ev9yDjdkGBp6mwypO9Yg" name="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Lymph_flow_rate_Liver_Pericentral" isDefault="1" displayUnit="l/min">
+                <Parameter id="snG81WA4r026qTfF4PZINw" name="Fluid recirculation flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate_Liver_Pericentral" isDefault="1" displayUnit="l/min">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
                   <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-                  <Info min="0" flag="62" seq="18" ref="0" bb="32" group="58" />
+                  <Info min="0" flag="62" seq="18" ref="0" bb="32" group="27" />
                 </Parameter>
-                <Parameter id="I7hdglOR5UKEtK0c4E2nYA" name="Fluid recirculation flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate_Liver_Pericentral" isDefault="1" displayUnit="l/min">
+                <Parameter id="ekZhTkRPT0iXGV3NCSjNkw" name="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Lymph_flow_rate_Liver_Pericentral" isDefault="1" displayUnit="l/min">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
                   <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-                  <Info min="0" flag="62" seq="18" ref="0" bb="32" group="27" />
+                  <Info min="0" flag="62" seq="18" ref="0" bb="32" group="58" />
                 </Parameter>
-                <Parameter id="iQVRAEvH3E2KeLwUlpd4Ng" name="Volume (endothelium)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="VascularEndoVolume.VOLUME_VascularEndo_liv_pericentral" isDefault="1" displayUnit="l">
+                <Parameter id="isJOdbq4U0uuuUPPIskHQg" name="Volume (endothelium)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="VascularEndoVolume.VOLUME_VascularEndo_liv_pericentral" isDefault="1" displayUnit="l">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
                   <Info min="0" flag="62" seq="18" ref="0" bb="32" group="127" />
                 </Parameter>
-                <Parameter id="gXPjRJhQhEKKi6RU4xx86Q" name="Vf (lipid)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (lipid)_LiverZone" isDefault="1">
+                <Parameter id="LBFPVLdIdEKpuli163UAlA" name="Vf (lipid)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (lipid)_LiverZone" isDefault="1">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
                   <Info min="0" max="1" flag="54" seq="51" ref="0" bb="32" group="85" />
                 </Parameter>
-                <Parameter id="Sa7_fNShr0yHF97XyKKRwA" name="Vf (neutral lipid)-PT" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (neutral lipid)-PT_LiverZone" isDefault="1">
+                <Parameter id="PVYPGU0GI02oB1oENmE7gg" name="Vf (neutral lipid)-PT" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (neutral lipid)-PT_LiverZone" isDefault="1">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
                   <Info min="0" max="1" flag="54" seq="51" ref="0" bb="32" group="86" />
                 </Parameter>
-                <Parameter id="yLm-14LWeUCtcaWHbW9b0g" name="Vf (phospholipid)-PT" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (phospholipid)-PT_LiverZone" isDefault="1">
+                <Parameter id="4vPPsjoSWkmc4jnGyVcEeA" name="Fraction vascular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Fraction vascular_LiverZone" isDefault="1">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
-                  <Info min="0" max="1" flag="54" seq="52" ref="0" bb="32" group="86" />
+                  <Info min="0" max="1" flag="54" seq="52" ref="0" bb="32" group="64" />
                 </Parameter>
-                <Parameter id="4xZnpdlYekKF4BiR3JsLEg" name="Vf (protein)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (protein)_LiverZone" isDefault="1">
+                <Parameter id="tyavwcgB9EWtoBzJPtbZKg" name="Vf (phospholipid)-PT" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (phospholipid)-PT_LiverZone" isDefault="1">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
-                  <Info min="0" max="1" flag="54" seq="52" ref="0" bb="32" group="85" />
+                  <Info min="0" max="1" flag="54" seq="52" ref="0" bb="32" group="86" />
                 </Parameter>
-                <Parameter id="2uGtQBVGZkWuMsM3jJo4kA" name="Fraction vascular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Fraction vascular_LiverZone" isDefault="1">
+                <Parameter id="cBwCiBJFyU29TT-rYwqHIw" name="Vf (protein)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (protein)_LiverZone" isDefault="1">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
-                  <Info min="0" max="1" flag="54" seq="52" ref="0" bb="32" group="64" />
+                  <Info min="0" max="1" flag="54" seq="52" ref="0" bb="32" group="85" />
                 </Parameter>
-                <Parameter id="2oxzpW48tUuFZ_Av76UX0Q" name="Lipoprotein ratio (tissue/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Lipoprotein ratio (tissue/plasma)_LiverZone" isDefault="1">
+                <Parameter id="IsnCKNzIAE2NiAokFq6SYg" name="Albumin ratio (tissue/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Albumin ratio (tissue/plasma)_LiverZone" isDefault="1">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
-                  <Info min="0" max="1" flag="54" seq="53" ref="0" bb="32" group="113" />
+                  <Info min="0" max="1" flag="54" seq="53" ref="0" bb="32" group="111" />
                 </Parameter>
-                <Parameter id="S3s4c3Lyo0GQQJ0tdE9W3A" name="Vf (water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (water)_LiverZone" isDefault="1">
+                <Parameter id="AFMJQ65yyUilwFKRhzIGbg" name="Albumin ratio (tissue/plasma)-PT" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Albumin ratio (tissue/plasma)-PT_LiverZone" isDefault="1">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
-                  <Info min="0" max="1" flag="54" seq="53" ref="0" bb="32" group="85" />
+                  <Info min="0" max="1" flag="54" seq="53" ref="0" bb="32" group="112" />
                 </Parameter>
-                <Parameter id="ucNYrbrH40Wif170sZjL5w" name="Vf (water)-PT" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (water)-PT_LiverZone" isDefault="1">
+                <Parameter id="6cKlTjpesEKw5vcy_lwaVg" name="Lipoprotein ratio (tissue/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Lipoprotein ratio (tissue/plasma)_LiverZone" isDefault="1">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
-                  <Info min="0" max="1" flag="54" seq="53" ref="0" bb="32" group="86" />
+                  <Info min="0" max="1" flag="54" seq="53" ref="0" bb="32" group="113" />
                 </Parameter>
-                <Parameter id="YnR5QYftUUKigHyPuQ51PQ" name="Number of cells/g tissue" icon="Parameter" persistable="0" isFixedValue="0" dim="Count per mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Number of cells/g tissue_LiverZone" isDefault="1" displayUnit="x10^6/g">
+                <Parameter id="0W65lNKTWkybzZtsSCqyag" name="Microsomal protein mass/g tissue" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass per tissue" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Microsomal protein mass/g tissue_LiverZone" isDefault="1" displayUnit="mg/g">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
-                  <Info min="0" max="1000000" flag="54" seq="53" ref="0" bb="32" group="61" />
+                  <Info min="0" max="1" flag="54" seq="53" ref="0" bb="32" group="59" />
                 </Parameter>
-                <Parameter id="aS1J-w4fV0GtyyakUqsE9Q" name="Microsomal protein mass/g tissue" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass per tissue" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Microsomal protein mass/g tissue_LiverZone" isDefault="1" displayUnit="mg/g">
+                <Parameter id="xTGS9cVqeE67r1tU0ZQkNw" name="Number of cells/g tissue" icon="Parameter" persistable="0" isFixedValue="0" dim="Count per mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Number of cells/g tissue_LiverZone" isDefault="1" displayUnit="x10^6/g">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
-                  <Info min="0" max="1" flag="54" seq="53" ref="0" bb="32" group="59" />
+                  <Info min="0" max="1000000" flag="54" seq="53" ref="0" bb="32" group="61" />
                 </Parameter>
-                <Parameter id="SADDIIPCqUq8vDrWOZK71Q" name="Albumin ratio (tissue/plasma)-PT" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Albumin ratio (tissue/plasma)-PT_LiverZone" isDefault="1">
+                <Parameter id="K4D12ScBu0icgePdJstLlg" name="Vf (water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (water)_LiverZone" isDefault="1">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
-                  <Info min="0" max="1" flag="54" seq="53" ref="0" bb="32" group="112" />
+                  <Info min="0" max="1" flag="54" seq="53" ref="0" bb="32" group="85" />
                 </Parameter>
-                <Parameter id="DnNyZSdWZkKQiVhAwTjyyw" name="Albumin ratio (tissue/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Albumin ratio (tissue/plasma)_LiverZone" isDefault="1">
+                <Parameter id="ZhqDPztk_EqtrI6A1H-0fg" name="Vf (water)-PT" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (water)-PT_LiverZone" isDefault="1">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
-                  <Info min="0" max="1" flag="54" seq="53" ref="0" bb="32" group="111" />
+                  <Info min="0" max="1" flag="54" seq="53" ref="0" bb="32" group="86" />
                 </Parameter>
-                <Parameter id="wA9jVhGPlE23xhueeIqS-g" name="Fraction intracellular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_f_cell_LiverZone" isDefault="1">
+                <Parameter id="ITZXkvr2MUSSxT6DMFcTAQ" name="Fraction intracellular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_f_cell_LiverZone" isDefault="1">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
                   <Info min="0" max="1" flag="54" seq="55" ref="0" bb="32" group="64" />
                 </Parameter>
-                <Parameter id="CHPLRHhqyEamdqHASUIdGg" name="Fraction interstitial" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Fraction interstitial_LiverZone" isDefault="1">
+                <Parameter id="JHnw1q1ORkqmMd5bBAf_Sg" name="Fraction interstitial" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Fraction interstitial_LiverZone" isDefault="1">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
                   <Info min="0" max="1" flag="54" seq="58" ref="0" bb="32" group="64" />
                 </Parameter>
-                <Parameter id="3bnxwFcrGUaIuGpwju9aQw" name="Vf (neutral lipid)-RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (neutral lipid)-RR_LiverZone" isDefault="1">
+                <Parameter id="DlsO9tSYV0S3d090rv8mHg" name="Vf (neutral lipid)-RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (neutral lipid)-RR_LiverZone" isDefault="1">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
                   <Info min="0" max="1" flag="54" seq="85" ref="0" bb="32" group="92" />
                 </Parameter>
-                <Parameter id="KEMU3Wmz8k6PUa99xYTNYQ" name="Vf (neutral lipid)-WS" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (neutral lipid)-WS_LiverZone" isDefault="1">
+                <Parameter id="pe0DfYWtskSFl5oq8Al36A" name="Vf (neutral lipid)-WS" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (neutral lipid)-WS_LiverZone" isDefault="1">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
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+                <Parameter id="2NcXbq1600eDbwHr7ghyVQ" name="Specific blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Specific blood flow rate_LiverZone" isDefault="1" displayUnit="ml/min/100g organ">
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+                    <Parameter id="eV7MYK58kkSMQlyZ4Hys3Q" name="FcRn concentration in container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.FcRn_in_Container_Interstitial" isDefault="1" displayUnit="µmol/l">
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+                    <Parameter id="weh3b1l5TEOHwars6ciKuA" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_pH_INT" isDefault="1">
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-                        <Parameter id="yLTW99bzBE2vqHjuznU-kg" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_liv" isDefault="1">
+                        <Parameter id="c2z4_iXO9kyU9KHY3QfcRQ" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_liv" isDefault="1">
                           <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                         </Parameter>
+                        <Parameter id="-7uf3GnobEacZErHpzn7fw" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
+                          <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                        </Parameter>
                       </Children>
                     </Container>
                   </Children>
                 </Container>
-                <Container id="ADGxe55YKkSo-_woISm5ag" name="Intracellular" mode="Physical" containerType="Compartment">
+                <Container id="ds63kU5tRUKYhDEg557hxw" name="Intracellular" mode="Physical" containerType="Compartment">
                   <Tags>
                     <Tag value="Liver" />
                     <Tag value="Pericentral" />
                   </Tags>
                   <Children>
-                    <Parameter id="qa9T0qVMlU2Bz0f7b1rEVw" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" isDefault="1" displayUnit="l">
+                    <Parameter id="E4AB87lcv0mjGZvWi8HODQ" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" isDefault="1" displayUnit="l">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                     </Parameter>
-                    <Parameter id="x1GNOES1Z0qlSbxyXRpjPw" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_cell_2Pores" isDefault="1" displayUnit="l">
+                    <Parameter id="iMSjGou_vE-hVv5cl0XlPA" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_cell_2Pores" isDefault="1" displayUnit="l">
                       <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                       <Info min="0" flag="62" seq="17" ref="0" bb="2" group="125" />
                     </Parameter>
-                    <Parameter id="QKwNwBmZg0qQDtHcAqAZNA" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_PH_Cell_LiverZone" isDefault="1">
+                    <Parameter id="GClg50NM7km0F1B43qQA0w" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_PH_Cell_LiverZone" isDefault="1">
                       <Tags>
                         <Tag value="Liver" />
                         <Tag value="Pericentral" />
                       </Tags>
                       <Info min="0" max="14" flag="122" seq="56" ref="0" bb="32" group="83" />
                     </Parameter>
-                    <Container id="Iz_wUQXiI02vyJIv5I2P5Q" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                    <Container id="WMVWLd-8wUGLHMv4UBy7dw" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                       <Children>
-                        <Parameter id="5_66RlIsWUuNzTZMB3Oq2A" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_liv" isDefault="1">
+                        <Parameter id="ZtnDcfoklk-Ov8prFlkkzg" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                          <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                        </Parameter>
+                        <Parameter id="DI1W5aTkHEumxUIP51qGCw" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_liv" isDefault="1">
                           <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                         </Parameter>
-                        <Parameter id="LLobiklrZ0ulDOn_EgkZGw" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
+                        <Parameter id="ir8jBuPxdkmeTR5v1rmsBw" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
                           <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                         </Parameter>
-                        <Parameter id="1GnoqEvHM0GDE2J87XRCqg" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
-                          <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
-                        </Parameter>
                       </Children>
                     </Container>
                   </Children>
                 </Container>
-                <Container id="s6gle91W0UCjvKebGt-RWw" name="Endosome" mode="Physical" containerType="Compartment">
+                <Container id="A2G_T_PlKkihTSIW4WrDDA" name="Endosome" mode="Physical" containerType="Compartment">
                   <Tags>
                     <Tag value="Liver" />
                     <Tag value="Pericentral" />
                   </Tags>
                   <Children>
-                    <Parameter id="qWPJxJy1s0iyZRmkV5HmWQ" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
-                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
-                    </Parameter>
-                    <Parameter id="C5FSr6tM70OkhHE_Gi-_7w" name="FcRn concentration in container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.FcRn_in_Container_Endosomal" isDefault="1" displayUnit="µmol/l">
+                    <Parameter id="NXTXGIgSrEm-FRzFbFR1fg" name="FcRn concentration in container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.FcRn_in_Container_Endosomal" isDefault="1" displayUnit="µmol/l">
                       <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                       <Info flag="52" seq="1" ref="0" bb="2" group="25" />
                     </Parameter>
-                    <Parameter id="UJ8OUnN0XkWAdbO23O7XoQ" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_end_liv_pericentral" isDefault="1" displayUnit="l">
+                    <Parameter id="1kp-tYjvNkyARzY_TyI5BA" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                    </Parameter>
+                    <Parameter id="9OJ4E_zb8EWAo5l--p2lVA" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_end_liv_pericentral" isDefault="1" displayUnit="l">
                       <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                       <Info min="0" flag="122" seq="17" ref="0" bb="2" group="123" />
                     </Parameter>
-                    <Container id="fFH5xvfBNEyKe-rAvYn8fA" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                    <Container id="9zWI4UIr6kqcodPf2rtnLQ" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                       <Children>
-                        <Parameter id="JBmGoDDLy0WpHxDEz-yp9A" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Endosomal" isDefault="1" displayUnit="µmol/l">
+                        <Parameter id="-DruoxjpmUmWrDx-_AHACg" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Endosomal" isDefault="1" displayUnit="µmol/l">
                           <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                           <Info flag="52" seq="1" ref="0" bb="2" group="25" />
                         </Parameter>
-                        <Parameter id="XrKiqGUYY0KGzXblLXAsDw" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                        <Parameter id="Tk9BLVBt-kiF1pefceGZPQ" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                           <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                         </Parameter>
-                        <Parameter id="BrCWpuzVO0qnaMaIsAa2_w" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                        <Parameter id="zSgSS1800kyAtfJyGzpgeA" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
                           <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                           <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                         </Parameter>
-                        <Parameter id="Nm-S3b0mgk-3_1791Xt3Ow" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
+                        <Parameter id="QuqNR2RozUakqnvOakZC9w" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
                           <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                         </Parameter>
                       </Children>
@@ -13191,38 +13252,38 @@
                 </Container>
               </Children>
             </Container>
-            <Container id="n-Mf71iFs0a8ZdJwFks7Sw" name="Plasma" mode="Logical" containerType="Compartment">
+            <Container id="7SkxMTOrW0C-Wyspn31xrg" name="Plasma" mode="Logical" containerType="Compartment">
               <Tags>
                 <Tag value="Liver" />
               </Tags>
               <Children>
-                <Parameter id="MF_X_mOnZ0i8zV7gQck_Kw" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_pls_2Pores" isDefault="1" displayUnit="l">
+                <Parameter id="VK5DnYrQFkiZRXv7AVOqyQ" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_pls_2Pores" isDefault="1" displayUnit="l">
                   <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                   <Info min="0" flag="62" seq="17" ref="0" bb="2" group="126" />
                 </Parameter>
               </Children>
             </Container>
-            <Container id="ArBoBqehqUKVujYhz1E5xA" name="BloodCells" mode="Logical" containerType="Compartment">
+            <Container id="Nbo1DDe8rEC9JhYXUX1XIg" name="BloodCells" mode="Logical" containerType="Compartment">
               <Tags>
                 <Tag value="Liver" />
               </Tags>
               <Children>
-                <Parameter id="QA3XOvVePkWNWmiHQWcajw" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_bc_2Pores" isDefault="1" displayUnit="l">
+                <Parameter id="EzPNDoYAdEuZaEI2h8yxHQ" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_bc_2Pores" isDefault="1" displayUnit="l">
                   <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                   <Info min="0" flag="62" seq="17" ref="0" bb="2" group="121" />
                 </Parameter>
               </Children>
             </Container>
-            <Container id="o_Lcem1z20etqh8Xprm8iw" name="Interstitial" mode="Logical" containerType="Compartment">
+            <Container id="0QN8TWrhDE62xqF0I9sQlQ" name="Interstitial" mode="Logical" containerType="Compartment">
               <Tags>
                 <Tag value="Liver" />
               </Tags>
               <Children>
-                <Parameter id="JzJZ9nWig0iYvE386oeR-Q" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_int_2Pores" isDefault="1" displayUnit="l">
+                <Parameter id="LQtwfsKK00a_ciIS5hwz-w" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_int_2Pores" isDefault="1" displayUnit="l">
                   <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                   <Info min="0" flag="62" seq="17" ref="0" bb="2" group="124" />
                 </Parameter>
-                <Parameter id="HMFNVXU8OEiOVZBJA_ufZA" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_pH_INT" isDefault="1">
+                <Parameter id="BjOrGBfB2063URbPSnlb-w" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_pH_INT" isDefault="1">
                   <Tags>
                     <Tag value="Liver" />
                   </Tags>
@@ -13230,16 +13291,16 @@
                 </Parameter>
               </Children>
             </Container>
-            <Container id="R3ZqTlHFT0aa34rtqKRofA" name="Intracellular" mode="Logical" containerType="Compartment">
+            <Container id="cRXaTM3A4k27PbgqMR_z7g" name="Intracellular" mode="Logical" containerType="Compartment">
               <Tags>
                 <Tag value="Liver" />
               </Tags>
               <Children>
-                <Parameter id="Cl-bv_TmI0ui9lTLzezVoA" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_cell_2Pores" isDefault="1" displayUnit="l">
+                <Parameter id="z_bXtUNAgk-AeZb0BkOSfw" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_cell_2Pores" isDefault="1" displayUnit="l">
                   <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                   <Info min="0" flag="62" seq="17" ref="0" bb="2" group="125" />
                 </Parameter>
-                <Parameter id="-KsEwSdowUC0A_-l0tPDCQ" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.23">
+                <Parameter id="QiCqmLt0Lki5EO_Wm6xCKw" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.23">
                   <Tags>
                     <Tag value="Liver" />
                   </Tags>
@@ -13248,12 +13309,12 @@
                 </Parameter>
               </Children>
             </Container>
-            <Container id="zfM0AeAi4E-FLsNL4mYfPQ" name="Endosome" mode="Logical" containerType="Compartment">
+            <Container id="EP6smH6tEUmeDKVpO9sk_g" name="Endosome" mode="Logical" containerType="Compartment">
               <Tags>
                 <Tag value="Liver" />
               </Tags>
               <Children>
-                <Parameter id="Z3w8JsXa2ECYQFS2KDA1og" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_end_liv" isDefault="1" displayUnit="l">
+                <Parameter id="8unJDsdWWEyVmdKqyv-o9g" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_end_liv" isDefault="1" displayUnit="l">
                   <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                   <Info min="0" flag="122" seq="17" ref="0" bb="2" group="123" />
                 </Parameter>
@@ -13261,463 +13322,465 @@
             </Container>
           </Children>
         </Container>
-        <Container id="TvZw1hUTc0alJhGcUEowfA" name="Lung" mode="Logical" containerType="Organ">
+        <Container id="y4oMH4Y2PEWEyrp8US3CLA" name="Lung" mode="Logical" containerType="Organ">
           <Tags>
             <Tag value="TissueOrgan" />
           </Tags>
           <Children>
-            <Parameter id="VQkCB2OjmkiwgBuMYAyYYg" name="Fraction of endosomal uptake from plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_uptake_vas" isDefault="1">
+            <Parameter id="pSek-x7SdkChHJGVWPAFsQ" name="Fraction of endosomal uptake from plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_uptake_vas" isDefault="1">
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
               <Info min="0" flag="54" seq="0" ref="0" bb="2" group="25" />
             </Parameter>
-            <Parameter id="iez0KZLjhkKGlTirnPqPNg" name="Rate constant for endosomal uptake" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_K_uptake" isDefault="1" displayUnit="1/min">
+            <Parameter id="GaHgQ6zjv02H9sfRGSKz4w" name="Fraction endosomal" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_endo" isDefault="1">
+              <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+              <Info min="0" max="1" flag="54" seq="1" ref="0" bb="2" group="29" />
+            </Parameter>
+            <Parameter id="DmviU3fCdEK70VIHNh5aFA" name="Fraction recycled to plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_rec_vas" isDefault="1">
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
               <Info min="0" flag="54" seq="1" ref="0" bb="2" group="25" />
             </Parameter>
-            <Parameter id="q7hAatxBo0uJst_X-TtMSw" name="Fraction recycled to plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_rec_vas" isDefault="1">
+            <Parameter id="kFKaHQlVWU2f7nMExGg1Hg" name="Rate constant for endosomal uptake" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_K_uptake" isDefault="1" displayUnit="1/min">
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
               <Info min="0" flag="54" seq="1" ref="0" bb="2" group="25" />
             </Parameter>
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+                <Parameter id="WyH8vLOj-UGF21qG0LZT6g" name="FcRn concentration in container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.FcRn_in_Container_Interstitial" isDefault="1" displayUnit="µmol/l">
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                 </Parameter>
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+                <Parameter id="Fk1IhSlJAkKN0OnX6oBYbA" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                  <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                </Parameter>
+                <Parameter id="HtZ3Sk4kvUiSsUYDvIH0fQ" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_int_2Pores" isDefault="1" displayUnit="l">
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+                <Parameter id="k5YIbH9Uv0OeaqvcAoResg" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_pH_INT" isDefault="1">
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                 </Parameter>
-                <Container id="UyVTE-TxO021Lh3tIogr_w" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="jvJ2Bc8A6kSxxZs7ywWAZQ" name="MoleculeProperties" mode="Logical" containerType="Molecule">
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-                    <Parameter id="NYg2ZwyHDUWkl4_tw79mXQ" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Plasma_and_Interstitial" isDefault="1" displayUnit="µmol/l">
+                    <Parameter id="0LZ4T2_Vj0uT665Bn_yhEQ" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Plasma_and_Interstitial" isDefault="1" displayUnit="µmol/l">
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                     </Parameter>
-                    <Parameter id="ByGV2ejPDEGaa5rsvLjgeQ" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                    <Parameter id="miRA5-1aH0WacyMWQr_zLQ" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                     </Parameter>
-                    <Parameter id="-Zb_eieaZUid5wn3Rec3BA" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_lng" isDefault="1">
+                    <Parameter id="y40VD_UPN0WtcLuJsYBfoQ" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_lng" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                     </Parameter>
-                    <Parameter id="e_WDV3UFxkezLM2xNSsOMA" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
+                    <Parameter id="LX3BQxXJL0CskT2HMlmI1g" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
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                 </Container>
               </Children>
             </Container>
-            <Container id="B1I11L5ugUiDjzdr9Xcdjw" name="Intracellular" mode="Physical" containerType="Compartment">
+            <Container id="voNmUWz5pUmSLpJ6_qjfBA" name="Intracellular" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="Lung" />
               </Tags>
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-                <Parameter id="oYfGFKglqkCmrFQVy71QRg" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" isDefault="1" displayUnit="l">
+                <Parameter id="KgIy5j_exEiS0hZW66nn6A" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" isDefault="1" displayUnit="l">
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                 </Parameter>
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+                <Parameter id="7jhCPPQ3bkiMWoe9bxzhGw" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_cell_2Pores" isDefault="1" displayUnit="l">
                   <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                   <Info min="0" flag="62" seq="18" ref="0" bb="2" group="125" />
                 </Parameter>
-                <Parameter id="eAEyK3VrmkeC1jDW_SliZQ" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="6.6">
+                <Parameter id="9Lyp996_40SYhdtwtU5Rmw" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="6.6">
                   <Tags>
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                 </Parameter>
-                <Container id="CKJl0j9pYk6TQc-XdO07Ow" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="8iqOB5pHVEiF3RNwlm2kTg" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                   <Children>
-                    <Parameter id="coFoGmeEKEW1thDxxjPFbw" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                    <Parameter id="v-n6lubmQkyecE6N9DJWuQ" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
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                     </Parameter>
-                    <Parameter id="wpN64JTTdEiW8S-Bp9oqjw" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_lng" isDefault="1">
+                    <Parameter id="ZwWWiREbTkG30StavakOsw" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_lng" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                     </Parameter>
-                    <Parameter id="oJSseAyCOkytFGWhIF1csQ" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
+                    <Parameter id="COI3uQ8vEESpqAc3Nd12aw" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
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                     </Parameter>
                   </Children>
                 </Container>
               </Children>
             </Container>
-            <Container id="m5ypZNiFHU6dqZ_Z8BsG6w" name="Endosome" mode="Physical" containerType="Compartment">
+            <Container id="6sArPO4cRU2NlXDyLFMl7w" name="Endosome" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="Lung" />
               </Tags>
               <Children>
-                <Parameter id="zAIKz3H2-EGUF23zAeXKvQ" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
-                  <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
-                </Parameter>
-                <Parameter id="W0PkeHJqK0mKfeaK62NKJg" name="FcRn concentration in container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.FcRn_in_Container_Endosomal" isDefault="1" displayUnit="µmol/l">
+                <Parameter id="v9bbmp1C6E6blNyPEEoXxw" name="FcRn concentration in container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.FcRn_in_Container_Endosomal" isDefault="1" displayUnit="µmol/l">
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                 </Parameter>
-                <Parameter id="PHUxnlw7ckOfX0wL6eFPpg" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_end_lng" isDefault="1" displayUnit="l">
+                <Parameter id="wX18uRIOOUCyN3M-VQIO5A" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                  <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                </Parameter>
+                <Parameter id="gI4TCRD9akmTi31-05bEzg" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_end_lng" isDefault="1" displayUnit="l">
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                 </Parameter>
-                <Container id="Ah6Ws5mZY0etW0duc1WTXA" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="MQjxPujxBkS02Rl-sNEg4A" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                   <Children>
-                    <Parameter id="QtZOfB046UqtoTsFd-cxWQ" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
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-                    </Parameter>
-                    <Parameter id="muCC5VbABEu_e8kH2u7Q9w" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Endosomal" isDefault="1" displayUnit="µmol/l">
+                    <Parameter id="BC6euKA7qUKMcQMgIeLqKQ" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Endosomal" isDefault="1" displayUnit="µmol/l">
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                       <Info flag="52" seq="1" ref="0" bb="2" group="25" />
                     </Parameter>
-                    <Parameter id="yZmhz6YVVU6ajONk6nk_xw" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                    <Parameter id="L3UCMWhY2Ue2AaaguHTMYg" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                    </Parameter>
+                    <Parameter id="_6Eg65dxH0O9icR-pnhCag" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
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                     </Parameter>
-                    <Parameter id="g3i9iWl8h0GQaiANNQ0Sww" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
+                    <Parameter id="43U7TQMZEEqMlvCxYpXcqA" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
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@@ -13726,234 +13789,235 @@
             </Container>
           </Children>
         </Container>
-        <Container id="CdLZzljYJUSoESGU3n_hfA" name="Muscle" mode="Logical" containerType="Organ">
+        <Container id="rJZEdCNU_UaNmlCVXm3iqw" name="Muscle" mode="Logical" containerType="Organ">
           <Tags>
             <Tag value="TissueOrgan" />
           </Tags>
           <Children>
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+            <Parameter id="mitO1eZAokCXdGnE4Xw19g" name="Fraction of endosomal uptake from plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_uptake_vas" isDefault="1">
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+            <Parameter id="8yxaCDQxeki-NpYcZ-qQdw" name="Fraction endosomal" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_endo" isDefault="1">
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-              <Info min="0" flag="54" seq="1" ref="0" bb="2" group="25" />
-            </Parameter>
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-              <Tags>
-                <Tag value="TissueOrgan" />
-              </Tags>
-              <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
+              <Info min="0" max="1" flag="54" seq="1" ref="0" bb="2" group="29" />
             </Parameter>
-            <Parameter id="Q7XXGVo9ckKjmsapL0xQhQ" name="Rate constant for endosomal uptake" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_K_uptake" isDefault="1" displayUnit="1/min">
+            <Parameter id="bKfvTzb5aESeXEufAGQgdw" name="Fraction recycled to plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_rec_vas" isDefault="1">
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             </Parameter>
-            <Parameter id="B7IDAbMY50-1Z9JBPrTnWw" name="Fraction recycled to plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_rec_vas" isDefault="1">
+            <Parameter id="IodsnEUAd0eGWoXql-sYKQ" name="Rate constant for endosomal uptake" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_K_uptake" isDefault="1" displayUnit="1/min">
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-            <Parameter id="mWanVj6nz0Oc2pt0by6ElA" name="Fraction endosomal" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_endo" isDefault="1">
+            <Parameter id="ZiOF7xp5i0CnuNy4QVayXg" name="Rate constant for recycling from endosomal space" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_K_rec" isDefault="1" displayUnit="1/min">
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-              <Info min="0" max="1" flag="54" seq="1" ref="0" bb="2" group="29" />
+              <Info min="0" flag="54" seq="1" ref="0" bb="2" group="25" />
             </Parameter>
-            <Parameter id="XAzlWXjzfU-gVVPrYvY5Vw" name="Fluid recirculation flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate" isDefault="1" displayUnit="l/min">
+            <Parameter id="uRnehqRL4EOUNXUQOGY5lg" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
-              <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-              <Info min="0" flag="122" seq="19" ref="0" bb="32" group="27" />
+              <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
             </Parameter>
-            <Parameter id="ErhaWUbIZUGwgJg5JpI72g" name="Volume (endothelium)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="VascularEndoVolume.VOLUME_VascularEndo_mus" isDefault="1" displayUnit="l">
+            <Parameter id="pYhUQwKu6EuP_cOsn_lAZw" name="Fluid recirculation flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate" isDefault="1" displayUnit="l/min">
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                 <Tag value="TissueOrgan" />
               </Tags>
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+                <Tag value="TissueOrgan" />
+              </Tags>
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                 <Tag value="TissueOrgan" />
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                 <Tag value="TissueOrgan" />
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+                <Parameter id="MmTv_peHMESVFLJREN1zCw" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
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+            <DistributedParameter id="sC5u6AoCpUmD0Uf8v3sBMg" name="Vf (phospholipid)-PT" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="qg0LmdxfZEmgj01_czPFRQ" mode="Logical" isDefault="1">
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+                <Parameter id="2e0HjGAjF0iuFe76AZk6aA" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
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+                <Parameter id="kv9mVLxXH0at4aJOtMiJrw" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0072">
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+            <DistributedParameter id="UgHRCurOLk-ijjB3AOQmgw" name="Vf (protein)" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="SY1LeJTeVEO9fM4zEDxgtg" mode="Logical" isDefault="1">
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+                <Parameter id="PHdICM_V5E6lyqEqTPwpUQ" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
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+                <Parameter id="k83D0hZXAEuaUdBN3gsEZw" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.177">
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@@ -13977,12 +14041,12 @@
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+            <DistributedParameter id="1kSsrR53fUqJkdrs1_hkzw" name="Vf (water)" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="bkszbsya60S9o00-B4ItOw" mode="Logical" isDefault="1">
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+                <Parameter id="vHFo6xMKuU6NofDl0en89g" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
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+                <Parameter id="DDHB8aMJgk6AmH91fxV5-A" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.811">
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@@ -13992,12 +14056,12 @@
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+            <DistributedParameter id="dVuW9RV_P0-kpAALcP5v6g" name="Vf (water)-PT" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="x3eYpSbeQEiec-1rKeNuWQ" mode="Logical" isDefault="1">
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+                <Parameter id="Z2wvJJaOLkK8-6b6mbjCKw" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
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+                <Parameter id="WgnjrsiLA06BqmjlnQ9Z5A" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.76">
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@@ -14006,40 +14070,27 @@
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+            <DistributedParameter id="AQnTwYydskulnIvSmRywKQ" name="Fraction interstitial" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="dDlNIcKTn0GHf5x3YwByYA" mode="Logical" isDefault="1">
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+                <Parameter id="hknFhNLQZESdY0_L5LykIg" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
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+                <Parameter id="qAHGEn0e60eaKKvYb_Irlw" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.16">
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                 </Parameter>
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               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
+              <ValueOrigin id="40" source="Publication" description="Edginton, A.N., Schmitt, W. &amp; Willmann, S. Clin Pharmacokinet (2006) 45: 1013. https://doi.org/10.2165/00003088-200645100-00005" />
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+                <Parameter id="AG0IbJwXSEC7p1t9vl4i7Q" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
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+                <Parameter id="n8_9lumq2ki79i2aRg_4Bw" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.022">
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@@ -14049,26 +14100,26 @@
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+            <DistributedParameter id="x7Iy17u3Gk-mI_qI8Lj6Zw" name="Vf (neutral lipid)-WS" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="FenFLhIL-0SzRITUylmSig" mode="Logical" isDefault="1">
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+                <Parameter id="2e-YDfzQnUeKa1wDKJCQ8g" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
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+                <Parameter id="FAgTwEXw9UGjZmyPSx5yOw" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0049">
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                 <Tag value="TissueOrgan" />
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+              <Info min="0" max="1" flag="122" seq="95" ref="0" bb="32" group="95" />
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+            <DistributedParameter id="qNd6yxraSUeRzoWUE2BBDQ" name="Vf (neutral phospholipid)-RR" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="hyTLymw57063plmzTvD0gw" mode="Logical" isDefault="1">
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+                <Parameter id="KNu8TrKT6E2pBBn7v2hgPw" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
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+                <Parameter id="hzhbJbUqxkGty5A_rkwdAg" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0078">
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@@ -14078,12 +14129,26 @@
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+            <DistributedParameter id="OO5K0_rSIkaDx8gafiWA6w" name="Vf (neutral phospholipid, plasma)-WS" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="AHN0481RAU6RMcjBSZijhA" mode="Logical" isDefault="1">
+              <Children>
+                <Parameter id="PmdlnY6Z3UW88mpLqApOyw" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                  <Info min="0" flag="18" seq="1" ref="0" bb="32" group="95" />
+                </Parameter>
+                <Parameter id="H4XIfNTjCUK6DUazfQxtFA" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0042">
+                  <Info min="0" max="1" flag="50" seq="1" ref="0" bb="32" group="95" />
+                </Parameter>
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+                <Tag value="TissueOrgan" />
+              </Tags>
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+                <Parameter id="mW8u_ZLleUacrffFIvFGFA" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
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+                <Parameter id="aye5AILOAUWQZ9rEloKeeA" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.079">
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@@ -14092,12 +14157,12 @@
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+            <DistributedParameter id="8WQZY34eaka1w-kXUXzmYw" name="Vf (protein)-WS" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="8MhCJS7o6E2nVTACa3CHaw" mode="Logical" isDefault="1">
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+                <Parameter id="rH-iV3N9skmV2xxHH7tX_g" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
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+                <Parameter id="gUzhrlzjyEeaF4ALSvhXMw" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.19">
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@@ -14106,12 +14171,12 @@
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+            <DistributedParameter id="55YfLOlD3U2j59re1C-2Sw" name="Vf (intracellular water)-RR" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="c3Ij6K7qLkGz6XVXE3CV2A" mode="Logical" isDefault="1">
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+                <Parameter id="h31uMp6RM02MBB0la8DDUg" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
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                 </Parameter>
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+                <Parameter id="lbeHhMyniUiwHOysPGIVcg" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.666">
                   <Info min="0" max="1" flag="50" seq="1" ref="0" bb="32" group="92" />
                 </Parameter>
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@@ -14120,12 +14185,12 @@
               </Tags>
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             </DistributedParameter>
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+            <DistributedParameter id="OpeqznfB3UGzkhzVJMI_Tg" name="Vf (water)-WS" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="3PhfOgkoEk6tDVBNejszZg" mode="Logical" isDefault="1">
               <Children>
-                <Parameter id="BFsBiQYx5067bzaJrD4mig" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                <Parameter id="0QvKGY2bdUmZP_bjxOlqWQ" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
                   <Info min="0" flag="18" seq="1" ref="0" bb="32" group="95" />
                 </Parameter>
-                <Parameter id="zlq0JuEmi0CecOw1fg7UUQ" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.76">
+                <Parameter id="S7PLTVqi8kq9j36YgJ-Njg" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.76">
                   <Info min="0" max="1" flag="50" seq="1" ref="0" bb="32" group="95" />
                 </Parameter>
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@@ -14134,190 +14199,191 @@
               </Tags>
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             </DistributedParameter>
-            <DistributedParameter id="DN4QNcJknk6UPs5p1lpdeQ" name="Specific blood flow rate" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" formula="fR1xpwc0_UG1nkGkKDynBQ" mode="Logical" isDefault="1" displayUnit="ml/min/100g organ">
+            <DistributedParameter id="vpyWVdN86ECrQPF5MfZKzw" name="Specific blood flow rate" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" formula="mE30cQQou0ehTsr3qIYNpg" mode="Logical" isDefault="1" displayUnit="ml/min/100g organ">
               <Children>
-                <Parameter id="mbG0trjtBUyz9ym-hxr3WQ" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5" displayUnit="ml/min/100g organ">
+                <Parameter id="Zoq4_PUuvkyQ9-0dr9MMNA" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5" displayUnit="ml/min/100g organ">
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                 </Parameter>
-                <Parameter id="35WbyfWqT06BEey1Ocuy9w" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.03419" displayUnit="ml/min/100g organ">
+                <Parameter id="JDXz4C3MFEOUA-_7dlGLTw" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.03419" displayUnit="ml/min/100g organ">
                   <Info min="0" flag="50" seq="1" ref="0" bb="32" group="5" />
                 </Parameter>
-                <Parameter id="xYaY5Zg8J0GO22SwIu8N2Q" name="Deviation" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0017095" displayUnit="ml/min/100g organ">
+                <Parameter id="3X9wO3ql8Ea37gNylUqGmg" name="Deviation" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0017095" displayUnit="ml/min/100g organ">
                   <Info min="0" flag="18" seq="1" ref="0" bb="32" group="5" />
                 </Parameter>
               </Children>
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
+              <ValueOrigin id="40" source="Publication" description="Edginton, A.N., Schmitt, W. &amp; Willmann, S. Clin Pharmacokinet (2006) 45: 1013. https://doi.org/10.2165/00003088-200645100-00005" />
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             </DistributedParameter>
-            <Container id="l51KslyykkOxfiw6tYx29Q" name="Plasma" mode="Physical" containerType="Compartment">
+            <Container id="J6TvTdzQc0qHhjOUV7HN2A" name="Plasma" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="Muscle" />
               </Tags>
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-                <Parameter id="1vehVY8vuUS-YdMphW4-RQ" name="FcRn concentration in container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.FcRn_in_Container_Plasma" isDefault="1" displayUnit="µmol/l">
+                <Parameter id="pi6_9QEQK0C1RJ23GNUWiA" name="FcRn concentration in container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.FcRn_in_Container_Plasma" isDefault="1" displayUnit="µmol/l">
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                 </Parameter>
-                <Parameter id="ry_CJ3aH3UqddpFV6Ge_QQ" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                <Parameter id="GEjRx_De9U6kdbsVRssMBA" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
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                 </Parameter>
-                <Parameter id="qRouoXJUVE6dFJL5nu44bw" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_pls_2Pores" isDefault="1" displayUnit="l">
+                <Parameter id="j2iV0-HFjUGlYuBr0TpjEg" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_pls_2Pores" isDefault="1" displayUnit="l">
                   <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
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                 </Parameter>
-                <Container id="pRluNgF2aESz-76t-kpwuQ" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="RS0vTEX5UkqMfujNhhHW-w" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                   <Children>
-                    <Parameter id="dq28NuWSG0Cs-bOzJniB2w" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Plasma_and_Interstitial" isDefault="1" displayUnit="µmol/l">
+                    <Parameter id="IeeWyZWUa0Cpq5Z69L2z2w" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Plasma_and_Interstitial" isDefault="1" displayUnit="µmol/l">
                       <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
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                     </Parameter>
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+                    <Parameter id="wUJ3JvDJFUyTecxv2YaSQw" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
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                     </Parameter>
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-                    </Parameter>
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+                    <Parameter id="vTS2-nqqDkabXW9Txon4Sw" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                     </Parameter>
+                    <Parameter id="g-3mzFwsgEGAibbdybc0VA" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
+                      <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                    </Parameter>
                   </Children>
                 </Container>
               </Children>
             </Container>
-            <Container id="wB4puu63wEqnvWTKpCUHMQ" name="BloodCells" mode="Physical" containerType="Compartment">
+            <Container id="kD3oluKAvkyAZrqeM4x7lg" name="BloodCells" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="Muscle" />
               </Tags>
               <Children>
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+                <Parameter id="oaA3-KaLr0qyxNfm-Yz0UA" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
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                 </Parameter>
-                <Parameter id="9yW3C98qOUy58I_TILQ79w" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_bc_2Pores" isDefault="1" displayUnit="l">
+                <Parameter id="BgGSmAxaR0SJUcF6xbJa7w" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_bc_2Pores" isDefault="1" displayUnit="l">
                   <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
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                 </Parameter>
-                <Container id="52r5c-hInEyuVFaQ3qM-Vw" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="ERzBrI8M0kqhZEzw-KDzrA" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                   <Children>
-                    <Parameter id="tTnfwHaf_Eek8-svS1n0Nw" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                    <Parameter id="neZpJdiwb0ifj9SzmXRjRQ" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
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                     </Parameter>
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-                    </Parameter>
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+                    <Parameter id="9HF_UWv2TUKOeHERRGPA_w" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                     </Parameter>
+                    <Parameter id="C7hrQFAAk0iftKmpMqge9A" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
+                      <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                    </Parameter>
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                 </Container>
               </Children>
             </Container>
-            <Container id="L6YXDgHPcEOPmoASSlot2w" name="Interstitial" mode="Physical" containerType="Compartment">
+            <Container id="NoL4umyvkU67TnTPwQxaQg" name="Interstitial" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="Muscle" />
               </Tags>
               <Children>
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-                </Parameter>
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+                <Parameter id="Pe0-PT7pv0WtTvlsGC2NUw" name="FcRn concentration in container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.FcRn_in_Container_Interstitial" isDefault="1" displayUnit="µmol/l">
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                 </Parameter>
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+                <Parameter id="3ziU95XyukqSwwGiQMOzuw" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                  <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                </Parameter>
+                <Parameter id="wA_lU4QRUE6DJKsWAo-tfA" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_int_2Pores" isDefault="1" displayUnit="l">
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                 </Parameter>
-                <Parameter id="6mkNFeMgnketqaLb2inOeQ" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_pH_INT" isDefault="1">
+                <Parameter id="_tgWkoIga0Gzw84UP9x0OA" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_pH_INT" isDefault="1">
                   <Tags>
                     <Tag value="Muscle" />
                   </Tags>
                   <Info min="0" max="14" flag="122" seq="59" ref="0" bb="32" group="84" />
                 </Parameter>
-                <Container id="0qzu8R0X20uE4KJGeM_NnA" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="ol1u1ufYREaEDQUyveYQYA" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                   <Children>
-                    <Parameter id="Pw0EtIMMAECFZbptEQbhuA" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Plasma_and_Interstitial" isDefault="1" displayUnit="µmol/l">
+                    <Parameter id="ny8hDAA6E0uAVp_dvuNMEQ" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Plasma_and_Interstitial" isDefault="1" displayUnit="µmol/l">
                       <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                       <Info flag="52" seq="1" ref="0" bb="2" group="25" />
                     </Parameter>
-                    <Parameter id="4fAsZ3Q9kkWKGYC6-Mxp_A" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                    <Parameter id="iDz5BbrOck6Yr7e9ZqKAAg" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
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                     </Parameter>
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+                    <Parameter id="w-I_FhQxSUiQg09rrqgifw" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_mus" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                     </Parameter>
-                    <Parameter id="HDyLRCr3sU2blqd532oBFg" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
+                    <Parameter id="AHnv7cUyC0-JRCxNZBw8og" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
                       <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                     </Parameter>
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                 </Container>
               </Children>
             </Container>
-            <Container id="kHsjTwCHjU-nHlu3y7DDGg" name="Intracellular" mode="Physical" containerType="Compartment">
+            <Container id="YzO-mRTvjkKoEVlD4EVseA" name="Intracellular" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="Muscle" />
               </Tags>
               <Children>
-                <Parameter id="LAvo6qMHW0mgiU3vCC8Kig" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" isDefault="1" displayUnit="l">
+                <Parameter id="pkc5xXE-FU-8-9dL4FTqjQ" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" isDefault="1" displayUnit="l">
                   <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                 </Parameter>
-                <Parameter id="_xhEfwX43kiC5aOE7QaKtw" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_cell_2Pores" isDefault="1" displayUnit="l">
+                <Parameter id="h3uBMLVdiUiXdw-QX7x0OQ" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_cell_2Pores" isDefault="1" displayUnit="l">
                   <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                   <Info min="0" flag="62" seq="19" ref="0" bb="2" group="125" />
                 </Parameter>
-                <Parameter id="bvXVMq87qE6gqmX4mvBqiw" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="6.81">
+                <Parameter id="ptw0j4VfskKVvPHHc2OicA" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="6.81">
                   <Tags>
                     <Tag value="Muscle" />
                   </Tags>
                   <ValueOrigin id="34" source="Publication" description="Toxicol In Vitro. 2008 Mar;22(2):457-67 https://doi.org/10.1016/j.tiv.2007.09.010" />
                   <Info min="0" max="14" flag="122" seq="59" ref="0" bb="32" group="83" />
                 </Parameter>
-                <Container id="RG_lZgWNUUuxZ1KDC7T4jg" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="hM7aEi-NN0-VYGrrOqSj4g" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                   <Children>
-                    <Parameter id="xT-bRVzubkuDCcFP2F9PrQ" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                    <Parameter id="MMjuULDdeUub947WkzeYTw" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                     </Parameter>
-                    <Parameter id="CfSyqiipUEegL9yzupWmqA" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_mus" isDefault="1">
+                    <Parameter id="--1RT4sPa0ictrTNzC0qZw" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_mus" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                     </Parameter>
-                    <Parameter id="oJnkGBikgUOMUgCG7NMo_w" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
+                    <Parameter id="-j2jleG0NkKyWqd4TnT38w" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
                       <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                     </Parameter>
                   </Children>
                 </Container>
               </Children>
             </Container>
-            <Container id="2goE3ZwQykGya60S-lRRDA" name="Endosome" mode="Physical" containerType="Compartment">
+            <Container id="nSI2zw8jAUmcoznj3LyflA" name="Endosome" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="Muscle" />
               </Tags>
               <Children>
-                <Parameter id="KEpC0OYSxUiNLJuVbJB6aQ" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
-                  <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
-                </Parameter>
-                <Parameter id="hPGXdH33bU6qMmlg9xNvfg" name="FcRn concentration in container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.FcRn_in_Container_Endosomal" isDefault="1" displayUnit="µmol/l">
+                <Parameter id="G8065RzEJka9Qz6y2KPjrg" name="FcRn concentration in container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.FcRn_in_Container_Endosomal" isDefault="1" displayUnit="µmol/l">
                   <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                   <Info flag="52" seq="1" ref="0" bb="2" group="25" />
                 </Parameter>
-                <Parameter id="OaNFCYrQJkaAkUUg1VK7EA" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_end_mus" isDefault="1" displayUnit="l">
+                <Parameter id="QyCECm6FV0iiFMwRi7kQUg" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                  <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                </Parameter>
+                <Parameter id="GxtBVK-Zl0OsBAJz0-3uPQ" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_end_mus" isDefault="1" displayUnit="l">
                   <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                   <Info min="0" flag="122" seq="19" ref="0" bb="2" group="123" />
                 </Parameter>
-                <Container id="7L5RXiFPp0GP_1TUvVb2xg" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="GSdolr-BVk65MtdZfhewoA" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                   <Children>
-                    <Parameter id="oT6XwfX40UmpNEm9aY1FQw" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Endosomal" isDefault="1" displayUnit="µmol/l">
+                    <Parameter id="7JctJiaO-UaRkjRZBulFxA" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Endosomal" isDefault="1" displayUnit="µmol/l">
                       <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                       <Info flag="52" seq="1" ref="0" bb="2" group="25" />
                     </Parameter>
-                    <Parameter id="fq-pH40LZkCJzPGGlT_lYQ" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                    <Parameter id="xDFfcit9LkS5wdKezGEdLg" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                     </Parameter>
-                    <Parameter id="kq00W3IBuU2QNIVtVZXVug" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                    <Parameter id="C-DsPGbPGk6cNHszgJvs5w" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
                       <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                     </Parameter>
-                    <Parameter id="to8kSgGQekaACq5nXTs-tg" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
+                    <Parameter id="9jx5broD-UGw1QykEM25Fw" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
                       <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                     </Parameter>
                   </Children>
@@ -14326,47 +14392,40 @@
             </Container>
           </Children>
         </Container>
-        <Container id="Z2-_Ipgb_ki4XNLqbLJxRQ" name="Pancreas" mode="Logical" containerType="Organ">
+        <Container id="8vQid7hUmUmKqzLvIxi8ww" name="Pancreas" mode="Logical" containerType="Organ">
           <Tags>
             <Tag value="Portal Vein Supplying Organ" />
             <Tag value="TissueOrgan" />
           </Tags>
           <Children>
-            <Parameter id="_Sxq__GubE-SS2r-unLtIA" name="Fraction of endosomal uptake from plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_uptake_vas" isDefault="1">
+            <Parameter id="wTDMUk5AmEqg-kKaP6cHOQ" name="Fraction of endosomal uptake from plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_uptake_vas" isDefault="1">
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
               <Info min="0" flag="54" seq="0" ref="0" bb="2" group="25" />
             </Parameter>
-            <Parameter id="-H2zO8oTrkCeESr_Kpj3gg" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
-              <Tags>
-                <Tag value="Portal Vein Supplying Organ" />
-                <Tag value="TissueOrgan" />
-              </Tags>
-              <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
-            </Parameter>
-            <Parameter id="bqizdqT_bESVCEWNLb5j_A" name="Rate constant for recycling from endosomal space" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_K_rec" isDefault="1" displayUnit="1/min">
+            <Parameter id="2KVFkm0qkEu3l5clDk9Pcw" name="Fraction endosomal" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_endo" isDefault="1">
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-              <Info min="0" flag="54" seq="1" ref="0" bb="2" group="25" />
+              <Info min="0" max="1" flag="54" seq="1" ref="0" bb="2" group="29" />
             </Parameter>
-            <Parameter id="hD0qMt0lREG38fSCT-WMdg" name="Rate constant for endosomal uptake" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_K_uptake" isDefault="1" displayUnit="1/min">
+            <Parameter id="OngVVc4Q7UqlG4GNvV6eQg" name="Fraction recycled to plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_rec_vas" isDefault="1">
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
               <Info min="0" flag="54" seq="1" ref="0" bb="2" group="25" />
             </Parameter>
-            <Parameter id="3fcd-PER00ipvjgIu-1FVQ" name="Fraction recycled to plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_rec_vas" isDefault="1">
+            <Parameter id="2pkkTNW430q1adjrhMRlUA" name="Rate constant for endosomal uptake" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_K_uptake" isDefault="1" displayUnit="1/min">
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
               <Info min="0" flag="54" seq="1" ref="0" bb="2" group="25" />
             </Parameter>
-            <Parameter id="XdiIW7p7C0SmAG0a89ODHA" name="Fraction endosomal" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_endo" isDefault="1">
+            <Parameter id="GA9pjPi5eUWRH63CTmzVWQ" name="Rate constant for recycling from endosomal space" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_K_rec" isDefault="1" displayUnit="1/min">
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-              <Info min="0" max="1" flag="54" seq="1" ref="0" bb="2" group="29" />
+              <Info min="0" flag="54" seq="1" ref="0" bb="2" group="25" />
             </Parameter>
-            <Parameter id="RAzxcC0XFEiYajycA7jLig" name="Volume (endothelium)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="VascularEndoVolume.VOLUME_VascularEndo_pan" isDefault="1" displayUnit="l">
+            <Parameter id="L0I-RNJ7ZUqWFwhDt3CHRA" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
-              <Info min="0" flag="62" seq="20" ref="0" bb="32" group="127" />
+              <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
             </Parameter>
-            <Parameter id="7ADmqzQ5AkWtBnsPPec8lA" name="Fluid recirculation flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate" isDefault="1" displayUnit="l/min">
+            <Parameter id="MPls0j5mBUuM2lwzFJCb3A" name="Fluid recirculation flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate" isDefault="1" displayUnit="l/min">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
@@ -14374,7 +14433,7 @@
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
               <Info min="0" flag="122" seq="20" ref="0" bb="32" group="27" />
             </Parameter>
-            <Parameter id="jjQFKEZXwUO4UFgACDLydQ" name="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Lymph_flow_rate" isDefault="1" displayUnit="l/min">
+            <Parameter id="cmKF5rcV8kWmqSVg4bZ0Tg" name="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Lymph_flow_rate" isDefault="1" displayUnit="l/min">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
@@ -14382,64 +14441,71 @@
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
               <Info min="0" flag="122" seq="20" ref="0" bb="32" group="58" />
             </Parameter>
-            <Parameter id="StRE-Hog5USs5kBgnqZggQ" name="Fraction intracellular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_f_cell" isDefault="1">
+            <Parameter id="2JHHAZCnEEWqQ8mB4SH5Qg" name="Volume (endothelium)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="VascularEndoVolume.VOLUME_VascularEndo_pan" isDefault="1" displayUnit="l">
+              <Tags>
+                <Tag value="Portal Vein Supplying Organ" />
+                <Tag value="TissueOrgan" />
+              </Tags>
+              <Info min="0" flag="62" seq="20" ref="0" bb="32" group="127" />
+            </Parameter>
+            <Parameter id="TuLQWcxb60W6t8qs5fIStA" name="Fraction intracellular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_f_cell" isDefault="1">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" max="1" flag="62" seq="67" ref="0" bb="32" group="64" />
             </Parameter>
-            <Parameter id="EzZ020k6VU2lJE7cQmS6FQ" name="Blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_from_Qspec" isDefault="1" displayUnit="l/min">
+            <Parameter id="Q-GiGYYBoEWlYwOWIve8uw" name="Blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_from_Qspec" isDefault="1" displayUnit="l/min">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
-              <ValueOrigin id="48" description="TODO: Absolute from specific calculation" />
+              <ValueOrigin id="48" source="Other" description="Absolute value = specific value (i.e. value normalized to the volume of the organ) multiplied by the organ volume" />
               <Info min="0" flag="62" seq="182" ref="0" bb="32" group="5" />
             </Parameter>
-            <Parameter id="zE10j9HsJUuf9yQc4jze4Q" name="Density (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
+            <Parameter id="Ly2IDD6ph0SvL1I4YS1saQ" name="Density (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" flag="38" seq="1" ref="0" bb="32" group="21" />
             </Parameter>
-            <Parameter id="2u9LP2RvU0aoIXJW0CYNpw" name="Fluid recirculation flow proportionality factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.01">
+            <Parameter id="5fSUh4U1-EGRDYuNhZ6EtQ" name="Fluid recirculation flow proportionality factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.01">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" flag="54" seq="1" ref="0" bb="32" group="27" />
             </Parameter>
-            <Parameter id="OsDWx05kc0yfBLFm2xhapA" name="Lymph flow proportionality factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0303">
+            <Parameter id="z-HTJDK7lUyd60uxXNLViA" name="Lymph flow proportionality factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0303">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" flag="54" seq="1" ref="0" bb="32" group="58" />
             </Parameter>
-            <Parameter id="LZ3iZXMLLEqpImNNq9WEyg" name="Organ volume mouse" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.00013" displayUnit="l">
+            <Parameter id="GQ4IUaN7OEutm-M-DWb5ew" name="Organ volume mouse" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.00013" displayUnit="l">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" flag="54" seq="1" ref="0" bb="32" group="65" />
             </Parameter>
-            <Parameter id="M4Pg7CfhZ0CGSKnW4EOdVw" name="Allometric scale factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.75">
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@@ -14624,22 +14690,22 @@
               <ValueOrigin id="21" source="Publication" description="Rodgers T, Leahy D, Rowland M. Physiologically based pharmacokinetic modeling 1: predicting the tissue distribution of moderate-to-strong bases. J Pharm Sci. 2005 Jun;94(6):1259-76. https://doi.org/10.1002/jps.20322" />
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+            <Parameter id="IlVZdw_5k0C1FufuRoBxFQ" name="Vf (acidic phospholipids)-WS" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.00167">
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+            <DistributedParameter id="uKF79Xs2Ckqxu2gCeKjC1A" name="Volume" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="ZhmUN9YmvEOt-HyHNfdPmw" mode="Logical" isDefault="1" displayUnit="l">
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+                <Parameter id="ISVMLHo5WU2vExBOL5nEZA" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.501624146657963" displayUnit="l">
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+                <Parameter id="sOZv2--POkKmBmQQraA9xQ" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.19026527664" displayUnit="l">
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+                <Parameter id="hVpnRsP33UyuSBSVZl520g" name="Deviation" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.051153121992552" displayUnit="l">
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                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
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+            <DistributedParameter id="CMmjBuIxAUqq7_vFi7I2kw" name="Specific blood flow rate" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" formula="125vTF3QxEaEaR-QZBT0Ug" mode="Logical" isDefault="1" displayUnit="ml/min/100g organ">
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+                <Parameter id="oEy6Sk2e4UeYJdh6jlirIQ" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5" displayUnit="ml/min/100g organ">
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+                <Parameter id="UJeOeAZ-mEOs_fdQKHVi-A" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.3419" displayUnit="ml/min/100g organ">
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+                <Parameter id="ThsI6Hm-4kabhUhkBv89iA" name="Deviation" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.017095" displayUnit="ml/min/100g organ">
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@@ -14665,181 +14732,182 @@
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
+              <ValueOrigin id="40" source="Publication" description="Edginton, A.N., Schmitt, W. &amp; Willmann, S. Clin Pharmacokinet (2006) 45: 1013. https://doi.org/10.2165/00003088-200645100-00005" />
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                 <Tag value="Pancreas" />
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+                <Parameter id="lrmG89eVKkazBOuNq6KuJg" name="FcRn concentration in container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.FcRn_in_Container_Plasma" isDefault="1" displayUnit="µmol/l">
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+                <Parameter id="h_3BXY_ZQUWNXg2xNXoDsA" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
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+                </Parameter>
+                <Parameter id="lVN2GefOskWVFE4XUr5-Ew" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_pls_2Pores" isDefault="1" displayUnit="l">
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                 </Parameter>
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+                    <Parameter id="nQfK7GPQrEWL0D9m9qV2YA" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Plasma_and_Interstitial" isDefault="1" displayUnit="µmol/l">
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+                    <Parameter id="2pvXqhHEaUerzTsJTl-khA" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
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+                    <Parameter id="0z5rKnX_FkGU-TkCzc-baQ" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" isDefault="1">
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+                    <Parameter id="gVrEXAcsPkm6ndqCl5OITw" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
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                 <Tag value="Pancreas" />
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+                <Parameter id="_AJux9jj8kaEdLL09Wam5g" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
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+                <Parameter id="aWg9gbvQ3k-HIjUjST3Fhw" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_bc_2Pores" isDefault="1" displayUnit="l">
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                 </Parameter>
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+                    <Parameter id="0ZSgukNR8k67OfUXllmw3g" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
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+                    <Parameter id="VLOtZF7-mUefX6Rqj76F4Q" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" isDefault="1">
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+                    <Parameter id="RSWhMO2Us0GQqBZBpUXfyw" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
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               <Tags>
                 <Tag value="Pancreas" />
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+                <Parameter id="KSUJuKLMB0yGJhgmc5BOWg" name="FcRn concentration in container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.FcRn_in_Container_Interstitial" isDefault="1" displayUnit="µmol/l">
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+                <Parameter id="G9ZOufl2ZE2d6ke_ejnLsw" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
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+                <Parameter id="4o4UV-G3r0S2TnsM9Lw1Hw" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_int_2Pores" isDefault="1" displayUnit="l">
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+                <Parameter id="_fNvH8hzl0mZp7olRtcPBA" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_pH_INT" isDefault="1">
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                 </Parameter>
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+                    <Parameter id="MQQDH781W0GiIKD3tzWLWw" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
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+                    <Parameter id="RXVi_nLFsk2X7MOuvbv-gg" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_pan" isDefault="1">
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+            <Container id="98Vq8ACApEes9oIbIioZTw" name="Intracellular" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="Pancreas" />
                 <Tag value="Portal Vein Supplying Organ" />
               </Tags>
               <Children>
-                <Parameter id="ZN1zht1V9kCvtfaQ_v0_cg" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" isDefault="1" displayUnit="l">
+                <Parameter id="rua43C3cv0-IRkQxngE3yw" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" isDefault="1" displayUnit="l">
                   <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                 </Parameter>
-                <Parameter id="tJD--E0bLEajV66Rn_dTUA" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_cell_2Pores" isDefault="1" displayUnit="l">
+                <Parameter id="xechDo3_YkucMoIlVq6Vow" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_cell_2Pores" isDefault="1" displayUnit="l">
                   <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                   <Info min="0" flag="62" seq="20" ref="0" bb="2" group="125" />
                 </Parameter>
-                <Parameter id="8erVW8Aog0CI67ZPiPJc0w" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.4">
+                <Parameter id="JSz0cTAHtk2KLPhIA7NBuw" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.4">
                   <Tags>
                     <Tag value="Pancreas" />
                     <Tag value="Portal Vein Supplying Organ" />
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                   <Info min="0" max="14" flag="122" seq="62" ref="0" bb="32" group="83" />
                 </Parameter>
-                <Container id="1FP2l4BuPkWKxTasnFRmaA" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="K-OAv-efl0621wEhGDYmRA" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                   <Children>
-                    <Parameter id="WJef5MN10EStSiD2J7apUA" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                    <Parameter id="5mNoqySU2Uu8RXLG2jJQ-g" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                     </Parameter>
-                    <Parameter id="GTsKp4wn3UeKK-HaA8JtvQ" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_pan" isDefault="1">
+                    <Parameter id="9NzVtpgkJUKYQPfmmqcKTA" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_pan" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                     </Parameter>
-                    <Parameter id="Hrgg4_XqOkCTkNTTj_mYeQ" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
+                    <Parameter id="JxmZ78P5jkKC9k5BTWFj8g" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
                       <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                     </Parameter>
                   </Children>
                 </Container>
               </Children>
             </Container>
-            <Container id="NDXdmAE2kkWaPl7eZMsm4A" name="Endosome" mode="Physical" containerType="Compartment">
+            <Container id="zkGaR8tf5EOO3o_7zyiOzA" name="Endosome" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="Pancreas" />
                 <Tag value="Portal Vein Supplying Organ" />
               </Tags>
               <Children>
-                <Parameter id="zjvujQ2jgUalSryD4NDUvg" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
-                  <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
-                </Parameter>
-                <Parameter id="NNIpVIhxJUGfOw90tHuwfw" name="FcRn concentration in container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.FcRn_in_Container_Endosomal" isDefault="1" displayUnit="µmol/l">
+                <Parameter id="peyUnve_pUuHcx7C97lc6w" name="FcRn concentration in container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.FcRn_in_Container_Endosomal" isDefault="1" displayUnit="µmol/l">
                   <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                   <Info flag="52" seq="1" ref="0" bb="2" group="25" />
                 </Parameter>
-                <Parameter id="FhKtx1RVAEWteZjgM3rHPQ" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_end_pan" isDefault="1" displayUnit="l">
+                <Parameter id="JipZbHQMkUGVoSh6erXrtA" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                  <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                </Parameter>
+                <Parameter id="8A_QJI5W1USuTaPElnIc7A" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_end_pan" isDefault="1" displayUnit="l">
                   <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
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                 </Parameter>
-                <Container id="1TXFlmC6ukWG5-cEjnKMCQ" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="4tdUTOQHpE2TCdJYxL-BQA" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                   <Children>
-                    <Parameter id="X6YmPGQ-OkSm9GyJDlfi3w" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Endosomal" isDefault="1" displayUnit="µmol/l">
+                    <Parameter id="0atFKIZDi0uLEEGOpQoTWQ" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Endosomal" isDefault="1" displayUnit="µmol/l">
                       <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                       <Info flag="52" seq="1" ref="0" bb="2" group="25" />
                     </Parameter>
-                    <Parameter id="txebv91q3EehOcRr17k4Hg" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                    <Parameter id="DcWV2swVF0aov5pyrabAgw" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                     </Parameter>
-                    <Parameter id="jXBiFPBN4Um7apAb6pmDRw" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                    <Parameter id="pyCRZe9f4UWCIt9MyiExNA" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
                       <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                     </Parameter>
-                    <Parameter id="NswCViR2E0Obhq0DONoaPg" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
+                    <Parameter id="sj6CweQddkyvK7KebriM2Q" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
                       <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                     </Parameter>
                   </Children>
@@ -14848,119 +14916,120 @@
             </Container>
           </Children>
         </Container>
-        <Container id="Pjy3qHFeYE-qyhmpfbFuFA" name="PortalVein" mode="Logical" containerType="Organ">
+        <Container id="6pYd0YHqCUqQzd6azY64BA" name="PortalVein" mode="Logical" containerType="Organ">
           <Tags>
             <Tag value="BloodOrgan" />
           </Tags>
           <Children>
-            <Parameter id="PNy7YI0yV02eZh1LO4JIBg" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
+            <Parameter id="kBICplD48UC0ABVSkbx_eQ" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
               <Tags>
                 <Tag value="BloodOrgan" />
               </Tags>
               <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
             </Parameter>
-            <Parameter id="cVOyaNpUQEmKEUdU_dQtjw" name="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_Lymph_pve" isDefault="1" displayUnit="l/min">
+            <Parameter id="johDOWUTOkmWBk5M3wEK8Q" name="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_Lymph_pve" isDefault="1" displayUnit="l/min">
               <Tags>
                 <Tag value="BloodOrgan" />
               </Tags>
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
               <Info min="0" flag="62" seq="22" ref="0" bb="32" group="58" />
             </Parameter>
-            <Parameter id="a5D2GvywzkC_KPVtID22vQ" name="Blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_pve" isDefault="1" displayUnit="l/min">
+            <Parameter id="_CJcGO2XlUOi08OR4M-UQg" name="Blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_pve" isDefault="1" displayUnit="l/min">
               <Tags>
                 <Tag value="BloodOrgan" />
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               <Info min="0" flag="62" seq="190" ref="0" bb="32" group="5" />
             </Parameter>
-            <Parameter id="k795wud4MEOJsOHyohpTyw" name="Density (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
+            <Parameter id="RI0UvNTsf0SSz9R7cr-kBg" name="Density (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
               <Tags>
                 <Tag value="BloodOrgan" />
               </Tags>
               <Info min="0" flag="38" seq="1" ref="0" bb="32" group="21" />
             </Parameter>
-            <Parameter id="h6gctQbmEkunWoHgm7E7Cw" name="Allometric scale factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.75">
+            <Parameter id="-5hoLIoscEmubKvbwTOHVw" name="Allometric scale factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.75">
               <Tags>
                 <Tag value="BloodOrgan" />
               </Tags>
               <Info min="0.75" max="0.75" flag="52" seq="1" ref="0" bb="32" group="2" />
             </Parameter>
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+            <Parameter id="N1bz8G1EaEiCppJnktOlOQ" name="Fraction vascular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
               <Tags>
                 <Tag value="BloodOrgan" />
               </Tags>
               <Info min="0" max="1" flag="62" seq="69" ref="0" bb="32" group="64" />
             </Parameter>
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+            <DistributedParameter id="_PmIaMWWw0e6DQ8fxBVS4A" name="Volume" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="xPDrHgZyKEiRGR3jgamBqg" mode="Logical" isDefault="1" displayUnit="l">
               <Children>
-                <Parameter id="Dnc-cfIBA0qA0WZwxLT_cw" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.501204365708457" displayUnit="l">
+                <Parameter id="wkVoS0Iu-027HZ8dtALupA" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.501243764883788" displayUnit="l">
                   <Info min="0" flag="18" seq="1" ref="0" bb="32" group="65" />
                 </Parameter>
-                <Parameter id="5RVS-IhVYkS0nYvhqSVP-Q" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.83561581977504" displayUnit="l">
+                <Parameter id="9kpbqynxB0iJkHnEbD228g" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.0372237776" displayUnit="l">
                   <Info min="0" flag="34" seq="1" ref="0" bb="32" group="65" />
                 </Parameter>
-                <Parameter id="nibBecEEukWu1b_b2qPEEQ" name="Deviation" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.041780790988752" displayUnit="l">
+                <Parameter id="sqtbrVW7WUClsezjaayfbg" name="Deviation" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.05186118888" displayUnit="l">
                   <Info min="0" flag="18" seq="1" ref="0" bb="32" group="65" />
                 </Parameter>
               </Children>
               <Tags>
                 <Tag value="BloodOrgan" />
               </Tags>
+              <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
               <Info min="0" flag="106" seq="13" ref="0" bb="32" group="65" />
             </DistributedParameter>
-            <Container id="5TpyW0Sd9USQGXc2frzUgA" name="Plasma" mode="Physical" containerType="Compartment">
+            <Container id="d626iVqs-ESin5Db2bAqWg" name="Plasma" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="BloodOrgan" />
                 <Tag value="PortalVein" />
               </Tags>
               <Children>
-                <Parameter id="lpLVQeBrxUGziH5PQXtwjQ" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                <Parameter id="M1cMxLsoh0mt7w__nI2Y2A" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
                   <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                 </Parameter>
-                <Parameter id="_7Iv2X2N90qP-ljE4ePDbQ" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_pls_BloodOrgan_2Pores" isDefault="1" displayUnit="l">
+                <Parameter id="fXyZMOaAoU6pC-dsQ3ax5A" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_pls_BloodOrgan_2Pores" isDefault="1" displayUnit="l">
                   <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                   <Info min="0" flag="62" seq="22" ref="0" bb="2" group="126" />
                 </Parameter>
-                <Container id="lVZ-JKKlOUK88E3sERcvYg" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="j01-RVMcP0mdjsbICfKJ5A" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                   <Children>
-                    <Parameter id="xwAHK6MCC0SgQ9iP4Z4pzQ" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Plasma_and_Interstitial" isDefault="1" displayUnit="µmol/l">
+                    <Parameter id="cQTYs3fw20q7gI6md0RC5g" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Plasma_and_Interstitial" isDefault="1" displayUnit="µmol/l">
                       <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                       <Info flag="52" seq="1" ref="0" bb="2" group="25" />
                     </Parameter>
-                    <Parameter id="2kGLfKGp_kmpCjTLJvuI3g" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                    <Parameter id="GSiB84JdpUmpYJDEJq1uWw" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                     </Parameter>
-                    <Parameter id="mXryiAdJiU6vwlr-xrVM5w" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" isDefault="1">
+                    <Parameter id="JnP_TP0owEezzEk5HP6HPQ" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                     </Parameter>
-                    <Parameter id="ff5Vwt-oeEar_qU3v1YgGw" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
+                    <Parameter id="moOiViLKS0uSRfcmUh8V5g" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
                       <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                     </Parameter>
                   </Children>
                 </Container>
               </Children>
             </Container>
-            <Container id="oz2_zRPfzk-ZhQqUyIQ6kg" name="BloodCells" mode="Physical" containerType="Compartment">
+            <Container id="J7qhrNHWA0i3ePh_JHm2LQ" name="BloodCells" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="BloodOrgan" />
                 <Tag value="PortalVein" />
               </Tags>
               <Children>
-                <Parameter id="iX1yqhAN0kaglQ77eMzxeA" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                <Parameter id="pNMYj9D-uEO6bKP5IkDK8A" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
                   <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                 </Parameter>
-                <Parameter id="9lKdY4Ys5kCWJ7tn4zEv6A" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_bc_blood_organ_2Pores" isDefault="1" displayUnit="l">
+                <Parameter id="mPWPnvlY5EyAGsIKZe4OUQ" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_bc_blood_organ_2Pores" isDefault="1" displayUnit="l">
                   <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                   <Info min="0" flag="62" seq="22" ref="0" bb="2" group="121" />
                 </Parameter>
-                <Container id="XipGw050ikGU7SNf4PG4sQ" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="bYynuM6GpEC3U0xJ-CoBdw" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                   <Children>
-                    <Parameter id="hgW1i0wSqkaFtC-5sggDnQ" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                    <Parameter id="G9vVK4-2OU6MQX3qjFivsQ" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                     </Parameter>
-                    <Parameter id="u37TtUOR70GtgEYhKpLGDw" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" isDefault="1">
+                    <Parameter id="Q-oj5aiCVUupCPsNHT84dQ" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                     </Parameter>
-                    <Parameter id="KR0BhF6iD0W2C2oTE3-nag" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
+                    <Parameter id="kuHQwxmLf0CX5U5me89AQg" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
                       <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                     </Parameter>
                   </Children>
@@ -14969,482 +15038,484 @@
             </Container>
           </Children>
         </Container>
-        <Container id="8Mx8BOVvBkGTxHCY5FtniA" name="Skin" mode="Logical" containerType="Organ">
+        <Container id="V0Jn7mzZlUmzc28SrAm52A" name="Skin" mode="Logical" containerType="Organ">
           <Tags>
             <Tag value="TissueOrgan" />
           </Tags>
           <Children>
-            <Parameter id="8dJEymv-ZUSSZuzSIeJHxw" name="Fraction of endosomal uptake from plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_uptake_vas" isDefault="1">
+            <Parameter id="TawPBvvciUurNbhgtPoXVw" name="Fraction of endosomal uptake from plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_uptake_vas" isDefault="1">
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
               <Info min="0" flag="54" seq="0" ref="0" bb="2" group="25" />
             </Parameter>
-            <Parameter id="_Y7DKKY2ikivLNW0NIAU0g" name="Fraction recycled to plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_rec_vas" isDefault="1">
-              <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-              <Info min="0" flag="54" seq="1" ref="0" bb="2" group="25" />
-            </Parameter>
-            <Parameter id="nQEfu1uyhkKVIT_RIVSo0w" name="Fraction endosomal" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_endo" isDefault="1">
+            <Parameter id="hdwR6uNzMkSeiV6tyEgKHg" name="Fraction endosomal" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_endo" isDefault="1">
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
               <Info min="0" max="1" flag="54" seq="1" ref="0" bb="2" group="29" />
             </Parameter>
-            <Parameter id="7B4P5fhGMkmLUO_6Bv_6QA" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
-              <Tags>
-                <Tag value="TissueOrgan" />
-              </Tags>
-              <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
+            <Parameter id="3ZuqeeMo_EqRVvNNXaXMWA" name="Fraction recycled to plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_rec_vas" isDefault="1">
+              <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+              <Info min="0" flag="54" seq="1" ref="0" bb="2" group="25" />
             </Parameter>
-            <Parameter id="I3lFlJKpuEeaXErzZ_DmmA" name="Rate constant for recycling from endosomal space" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_K_rec" isDefault="1" displayUnit="1/min">
+            <Parameter id="OhX_4nxwuUquoATC4VyXwQ" name="Rate constant for endosomal uptake" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_K_uptake" isDefault="1" displayUnit="1/min">
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
               <Info min="0" flag="54" seq="1" ref="0" bb="2" group="25" />
             </Parameter>
-            <Parameter id="vrrI26IKqk--GKC9Id32Lw" name="Rate constant for endosomal uptake" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_K_uptake" isDefault="1" displayUnit="1/min">
+            <Parameter id="corITZ6BO0-h-ExCXtRFyw" name="Rate constant for recycling from endosomal space" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_K_rec" isDefault="1" displayUnit="1/min">
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
               <Info min="0" flag="54" seq="1" ref="0" bb="2" group="25" />
             </Parameter>
-            <Parameter id="NXSBvK8QIkuQQcuBQ4Tamw" name="Fluid recirculation flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate" isDefault="1" displayUnit="l/min">
+            <Parameter id="VrB7Z4fUZUm54gPDsTSQ2Q" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
-              <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-              <Info min="0" flag="122" seq="23" ref="0" bb="32" group="27" />
+              <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
             </Parameter>
-            <Parameter id="PJwezfJmykeEmudQgYmcsw" name="Volume (endothelium)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="VascularEndoVolume.VOLUME_VascularEndo_skn" isDefault="1" displayUnit="l">
+            <Parameter id="_NX9xg4SDkSHqPOUdLQd0A" name="Fluid recirculation flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate" isDefault="1" displayUnit="l/min">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
-              <Info min="0" flag="62" seq="23" ref="0" bb="32" group="127" />
+              <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+              <Info min="0" flag="122" seq="23" ref="0" bb="32" group="27" />
             </Parameter>
-            <Parameter id="sTJmGck9yUm9yrrl196Xug" name="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Lymph_flow_rate" isDefault="1" displayUnit="l/min">
+            <Parameter id="a0T0vXr0x0WDqGvjWMAINA" name="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Lymph_flow_rate" isDefault="1" displayUnit="l/min">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
               <Info min="0" flag="122" seq="23" ref="0" bb="32" group="58" />
             </Parameter>
-            <Parameter id="ee2JkrZ7vEeDT7jx7Irm1Q" name="Fraction intracellular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_f_cell" isDefault="1">
+            <Parameter id="SNR85k4UEUiYsRwzM0uU3A" name="Volume (endothelium)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="VascularEndoVolume.VOLUME_VascularEndo_skn" isDefault="1" displayUnit="l">
+              <Tags>
+                <Tag value="TissueOrgan" />
+              </Tags>
+              <Info min="0" flag="62" seq="23" ref="0" bb="32" group="127" />
+            </Parameter>
+            <Parameter id="Ge5OxHOoxUmrWIWDqPHJYA" name="Fraction intracellular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_f_cell" isDefault="1">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" max="1" flag="62" seq="71" ref="0" bb="32" group="64" />
             </Parameter>
-            <Parameter id="bXhhBufJbUqrEgQwQnnI5w" name="Blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_from_Qspec" isDefault="1" displayUnit="l/min">
+            <Parameter id="_YgXmPy70UmQJaYuqsLFAQ" name="Blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_from_Qspec" isDefault="1" displayUnit="l/min">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
-              <ValueOrigin id="48" description="TODO: Absolute from specific calculation" />
+              <ValueOrigin id="48" source="Other" description="Absolute value = specific value (i.e. value normalized to the volume of the organ) multiplied by the organ volume" />
               <Info min="0" flag="62" seq="202" ref="0" bb="32" group="5" />
             </Parameter>
-            <Parameter id="egIfXB8jVU2dj2NwKsVuQA" name="Density (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
+            <Parameter id="G6yzDlBvgkSz-vMDjG4U1A" name="Density (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" flag="38" seq="1" ref="0" bb="32" group="21" />
             </Parameter>
-            <Parameter id="fyXB7P-L1kW5tSH4Qv00rg" name="Fluid recirculation flow proportionality factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.617">
+            <Parameter id="rHeItaG_LUmq3nHMdGsK-w" name="Fluid recirculation flow proportionality factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.617">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" flag="54" seq="1" ref="0" bb="32" group="27" />
             </Parameter>
-            <Parameter id="a6P_3RoxaUCp9m7PLumJHg" name="Lymph flow proportionality factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.00352">
+            <Parameter id="PI1258UEp0yaDtPhXaGrVw" name="Lymph flow proportionality factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.00352">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" flag="54" seq="1" ref="0" bb="32" group="58" />
             </Parameter>
-            <Parameter id="i7RTWbiklkulQcJA-YbTfQ" name="Organ volume mouse" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0029" displayUnit="l">
+            <Parameter id="hulDONbu3Ue0R1F634iVsg" name="Organ volume mouse" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0029" displayUnit="l">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" flag="54" seq="1" ref="0" bb="32" group="65" />
             </Parameter>
-            <Parameter id="uHRB4YZ42kedOH_pPBiVkA" name="Peripheral blood flow fraction" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.713">
+            <Parameter id="jHNsQONJVk-4_Nk33PjY5A" name="Peripheral blood flow fraction" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.713">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <ValueOrigin id="46" source="Publication" description="Thiel C, Schneckener S, Krauss M, Ghallab A, Hofmann U, et al. A systematic evaluation of the use of physiologically based pharmacokinetic modeling for cross-species extrapolation. J Pharm Sci. 2015 Jan;104(1):191-206 https://doi.org/10.1002/jps.24214" />
               <Info min="0" max="1" flag="122" seq="1" ref="0" bb="32" group="74" />
             </Parameter>
-            <Parameter id="dQb2G2N2qkewUiVh6U_qxA" name="Allometric scale factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.6">
+            <Parameter id="NetIMqF2T0althE7yYuMqw" name="Allometric scale factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.6">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="1.6" max="1.6" flag="54" seq="1" ref="0" bb="32" group="2" />
             </Parameter>
-            <Parameter id="qociECb7mE-LQtddc9gaeA" name="Fraction of blood for sampling" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+            <Parameter id="Pxq9zVYhI0i8q9LEmrCqYA" name="Fraction of blood for sampling" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" max="1" flag="54" seq="1" ref="0" bb="32" group="94" />
             </Parameter>
-            <Parameter id="cq9qnZgj5U2KarqIomVQpg" name="Fraction vascular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.046">
+            <Parameter id="fAe3cjEJR0GSnDtlYclp8Q" name="Fraction vascular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.046">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <ValueOrigin id="40" source="Publication" description="Edginton, A.N., Schmitt, W. &amp; Willmann, S. Clin Pharmacokinet (2006) 45: 1013. https://doi.org/10.2165/00003088-200645100-00005" />
               <Info min="0" max="1" flag="62" seq="10" ref="0" bb="32" group="64" />
             </Parameter>
-            <Parameter id="JoiYN7R_6EamT0bpMvy-iQ" name="Flow fraction via large pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.05">
+            <Parameter id="0wrfkq0xu0aX9sA6gDpALw" name="Flow fraction via large pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.05">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
               <Info min="0" max="1" flag="122" seq="23" ref="0" bb="32" group="114" />
             </Parameter>
-            <Parameter id="glt30ohCl0OlGyROicVV8g" name="Hydraulic conductivity" icon="Parameter" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.94722E-11" displayUnit="ml/min/N">
+            <Parameter id="a4Z-YYxigkyAQ01AeIN7bw" name="Hydraulic conductivity" icon="Parameter" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.94722E-11" displayUnit="ml/min/N">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
               <Info min="0" flag="122" seq="23" ref="0" bb="32" group="115" />
             </Parameter>
-            <Parameter id="YSKbnpwPU0egiZijFmgGSg" name="Radius (small pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="4.5E-08" displayUnit="µm">
+            <Parameter id="j17uk_zNZku4xLQ7taM9Lw" name="Radius (large pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.5E-07" displayUnit="µm">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-              <Info min="0" flag="122" seq="23" ref="0" bb="32" group="99" />
+              <Info min="0" flag="122" seq="23" ref="0" bb="32" group="55" />
             </Parameter>
-            <Parameter id="CDWEjimV3Uu3GnuBlDBHlw" name="Radius (large pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.5E-07" displayUnit="µm">
+            <Parameter id="jDNrFDAB5EC_jDSsh5LIiw" name="Radius (small pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="4.5E-08" displayUnit="µm">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-              <Info min="0" flag="122" seq="23" ref="0" bb="32" group="55" />
+              <Info min="0" flag="122" seq="23" ref="0" bb="32" group="99" />
             </Parameter>
-            <Parameter id="4gx7Kciie0yoyrBCQVF50w" name="Vf (lipid)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.1">
+            <Parameter id="pzTKsDRWckK-hR0TMomy-A" name="Vf (lipid)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.1">
               <Tags>
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-                    <Parameter id="YXJEkBrTCUa7vJToh3dP4A" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
-                      <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
-                    </Parameter>
-                    <Parameter id="upGkLvloT0aP4ak5CfKTSg" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Endosomal" isDefault="1" displayUnit="µmol/l">
+                    <Parameter id="PvfYC_Ovh0-FMTpdCB0lKw" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Endosomal" isDefault="1" displayUnit="µmol/l">
                       <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                       <Info flag="52" seq="1" ref="0" bb="2" group="25" />
                     </Parameter>
-                    <Parameter id="fNbeHkCTDUGlnH7Jc_dYRg" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                    <Parameter id="tnatcR7aAU6I8mRsDOaadQ" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                    </Parameter>
+                    <Parameter id="TbjixsSh1kiCxGcqdlU7aw" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
                       <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                     </Parameter>
-                    <Parameter id="JbP88AObW0ievP3Csmf2Ug" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
-                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                    <Parameter id="2dViYucjg0mSTg6Wb-uorQ" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
+                      <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                     </Parameter>
                   </Children>
                 </Container>
@@ -15452,40 +15523,40 @@
             </Container>
           </Children>
         </Container>
-        <Container id="fVbFovXmgEKdEFFB60lIcA" name="Spleen" mode="Logical" containerType="Organ">
+        <Container id="0G4aMRLfqUeW2970PzjZ_g" name="Spleen" mode="Logical" containerType="Organ">
           <Tags>
             <Tag value="Portal Vein Supplying Organ" />
             <Tag value="TissueOrgan" />
           </Tags>
           <Children>
-            <Parameter id="7pvhEWdUGU2vATfa3qBVTw" name="Fraction of endosomal uptake from plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_uptake_vas" isDefault="1">
+            <Parameter id="swH0HxovU0SY9GctJIiLgA" name="Fraction of endosomal uptake from plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_uptake_vas" isDefault="1">
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
               <Info min="0" flag="54" seq="0" ref="0" bb="2" group="25" />
             </Parameter>
-            <Parameter id="EoW-gChIEkSwPD52Hml2Dg" name="Rate constant for endosomal uptake" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_K_uptake" isDefault="1" displayUnit="1/min">
+            <Parameter id="BvpzA-dgpUaiNqlpeJhB_g" name="Fraction endosomal" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_endo" isDefault="1">
+              <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+              <Info min="0" max="1" flag="54" seq="1" ref="0" bb="2" group="29" />
+            </Parameter>
+            <Parameter id="7R82bDGoH0aJnQNPh15fKA" name="Fraction recycled to plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_rec_vas" isDefault="1">
+              <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+              <Info min="0" flag="54" seq="1" ref="0" bb="2" group="25" />
+            </Parameter>
+            <Parameter id="wFM9FxjRoEamoQhTSFHH3Q" name="Rate constant for endosomal uptake" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_K_uptake" isDefault="1" displayUnit="1/min">
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
               <Info min="0" flag="54" seq="1" ref="0" bb="2" group="25" />
             </Parameter>
-            <Parameter id="aoCqDRoNn0Sxe50xAXF-Gg" name="Fraction recycled to plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_rec_vas" isDefault="1">
+            <Parameter id="numfje2tZ0-tSk31d9aDSQ" name="Rate constant for recycling from endosomal space" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_K_rec" isDefault="1" displayUnit="1/min">
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
               <Info min="0" flag="54" seq="1" ref="0" bb="2" group="25" />
             </Parameter>
-            <Parameter id="q9Touz6ZfkOxr_9T6O-QIg" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
+            <Parameter id="7XJF2n-_qEWYsYTKMjy2UA" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
             </Parameter>
-            <Parameter id="MorK542BYkys9Y1_4Lzjqg" name="Rate constant for recycling from endosomal space" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_K_rec" isDefault="1" displayUnit="1/min">
-              <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-              <Info min="0" flag="54" seq="1" ref="0" bb="2" group="25" />
-            </Parameter>
-            <Parameter id="jZuEWM8kVEaBu2SGa1rDUQ" name="Fraction endosomal" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_endo" isDefault="1">
-              <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-              <Info min="0" max="1" flag="54" seq="1" ref="0" bb="2" group="29" />
-            </Parameter>
-            <Parameter id="ZwBlXu61o0eZ8ggMKM6s9w" name="Fluid recirculation flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate" isDefault="1" displayUnit="l/min">
+            <Parameter id="EIj7kDv-CkKbBL6Pkwt2Bw" name="Fluid recirculation flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate" isDefault="1" displayUnit="l/min">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
@@ -15493,7 +15564,7 @@
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
               <Info min="0" flag="122" seq="24" ref="0" bb="32" group="27" />
             </Parameter>
-            <Parameter id="_M0PMiQ5JEGav8RBPQMzpQ" name="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Lymph_flow_rate" isDefault="1" displayUnit="l/min">
+            <Parameter id="4R228x-xzU6S9AfIp6XvXQ" name="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Lymph_flow_rate" isDefault="1" displayUnit="l/min">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
@@ -15501,103 +15572,103 @@
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
               <Info min="0" flag="122" seq="24" ref="0" bb="32" group="58" />
             </Parameter>
-            <Parameter id="2ZNqLGF1YEaNrpS8Bz1zzA" name="Volume (endothelium)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="VascularEndoVolume.VOLUME_VascularEndo_spl" isDefault="1" displayUnit="l">
+            <Parameter id="_1j6LLEkb0eeVUi2wPa6-g" name="Volume (endothelium)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="VascularEndoVolume.VOLUME_VascularEndo_spl" isDefault="1" displayUnit="l">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" flag="62" seq="24" ref="0" bb="32" group="127" />
             </Parameter>
-            <Parameter id="LBMoCnfIhkGD4q49LERjOg" name="Fraction intracellular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_f_cell" isDefault="1">
+            <Parameter id="DBmB7RuFzEuVumS-0-B2QA" name="Fraction intracellular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_f_cell" isDefault="1">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" max="1" flag="62" seq="74" ref="0" bb="32" group="64" />
             </Parameter>
-            <Parameter id="VgAiuB1IOkO_PB_MkCmAMw" name="Blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_from_Qspec" isDefault="1" displayUnit="l/min">
+            <Parameter id="gS89Xyymgka7YsZ5dBsE1g" name="Blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_from_Qspec" isDefault="1" displayUnit="l/min">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
-              <ValueOrigin id="48" description="TODO: Absolute from specific calculation" />
+              <ValueOrigin id="48" source="Other" description="Absolute value = specific value (i.e. value normalized to the volume of the organ) multiplied by the organ volume" />
               <Info min="0" flag="62" seq="242" ref="0" bb="32" group="5" />
             </Parameter>
-            <Parameter id="hk7iZPZgakOgs6UblwnSuA" name="Density (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
+            <Parameter id="2gwqYzwGFEqloWCgtcq1iA" name="Density (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" flag="38" seq="1" ref="0" bb="32" group="21" />
             </Parameter>
-            <Parameter id="b0mV1iX0xEmM3PT4qqnhYg" name="Fluid recirculation flow proportionality factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.01">
+            <Parameter id="y3S3pzleqU--NurcZ0FVIA" name="Fluid recirculation flow proportionality factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.01">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" flag="54" seq="1" ref="0" bb="32" group="27" />
             </Parameter>
-            <Parameter id="PcVvSagDHkiWCCveaX2zVg" name="Lymph flow proportionality factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0199">
+            <Parameter id="vm5AvCdyJUCkEcmybsFkBg" name="Lymph flow proportionality factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0199">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" flag="54" seq="1" ref="0" bb="32" group="58" />
             </Parameter>
-            <Parameter id="Vne7M9jQX061QDuZ9bYDVg" name="Organ volume mouse" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0001" displayUnit="l">
+            <Parameter id="PIAGZ4BZiUO-ns5fRV3Iqw" name="Organ volume mouse" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0001" displayUnit="l">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" flag="54" seq="1" ref="0" bb="32" group="65" />
             </Parameter>
-            <Parameter id="VIejTKSgMEaUpMBAetJMxw" name="Allometric scale factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.75">
+            <Parameter id="NpUY6tq6wk6K8Mrdb4XuQg" name="Allometric scale factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.75">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0.75" max="0.75" flag="54" seq="1" ref="0" bb="32" group="2" />
             </Parameter>
-            <Parameter id="EPR3gHh5VESDk8absvdKLA" name="Fraction of blood for sampling" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+            <Parameter id="F1yRp-AwKkWL1oTnAbQTrw" name="Fraction of blood for sampling" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" max="1" flag="54" seq="1" ref="0" bb="32" group="94" />
             </Parameter>
-            <Parameter id="WM89vclB3U6ps3dt2urNbg" name="Hydraulic conductivity" icon="Parameter" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="3.88888888888889E-11" displayUnit="ml/min/N">
+            <Parameter id="tpqASw5yxUel8LESWrxzAQ" name="Flow fraction via large pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.8">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-              <Info min="0" flag="122" seq="24" ref="0" bb="32" group="115" />
+              <Info min="0" max="1" flag="122" seq="24" ref="0" bb="32" group="114" />
             </Parameter>
-            <Parameter id="5TTsQMPBrEGjHE7Me8hp1Q" name="Radius (small pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="9E-08" displayUnit="µm">
+            <Parameter id="yQmmfEIy5UCzFOUFsgqnrw" name="Hydraulic conductivity" icon="Parameter" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="3.88888888888889E-11" displayUnit="ml/min/N">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-              <Info min="0" flag="122" seq="24" ref="0" bb="32" group="99" />
+              <Info min="0" flag="122" seq="24" ref="0" bb="32" group="115" />
             </Parameter>
-            <Parameter id="sZzpFTrfrUO8iG-9uZJ04A" name="Flow fraction via large pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.8">
+            <Parameter id="jYQR32wK6Um1sXmw1AJbLw" name="Radius (large pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="3.3E-07" displayUnit="µm">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-              <Info min="0" max="1" flag="122" seq="24" ref="0" bb="32" group="114" />
+              <Info min="0" flag="122" seq="24" ref="0" bb="32" group="55" />
             </Parameter>
-            <Parameter id="d_ZdT3DsvUCWHYvOlUjaHw" name="Radius (large pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="3.3E-07" displayUnit="µm">
+            <Parameter id="d9Vg2mzm506FUtEpJnCKzA" name="Radius (small pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="9E-08" displayUnit="µm">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-              <Info min="0" flag="122" seq="24" ref="0" bb="32" group="55" />
+              <Info min="0" flag="122" seq="24" ref="0" bb="32" group="99" />
             </Parameter>
-            <Parameter id="8lThBYY1vUCklF4FSzvLug" name="Vf (lipid)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.016">
+            <Parameter id="3pSzA7qwAk66I-UHiop4qA" name="Vf (lipid)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.016">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
@@ -15605,45 +15676,45 @@
               <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
               <Info min="0" max="1" flag="122" seq="72" ref="0" bb="32" group="85" />
             </Parameter>
-            <Parameter id="UOFc6BI34Ui-tzf3T1MfYA" name="Vf (neutral lipid)-PT" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0201">
+            <Parameter id="DGEUt2XjdkC0-dl50UL_Kw" name="Vf (neutral lipid)-PT" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0201">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" max="1" flag="122" seq="72" ref="0" bb="32" group="86" />
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+                <Parameter id="ntAMXap-T02m7UCw-detMA" name="Deviation" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.04005625" displayUnit="ml/min/100g organ">
                   <Info min="0" flag="18" seq="1" ref="0" bb="32" group="5" />
                 </Parameter>
               </Children>
@@ -15791,129 +15863,130 @@
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
+              <ValueOrigin id="40" source="Publication" description="Edginton, A.N., Schmitt, W. &amp; Willmann, S. Clin Pharmacokinet (2006) 45: 1013. https://doi.org/10.2165/00003088-200645100-00005" />
               <Info min="0" flag="122" seq="241" ref="0" bb="32" group="5" />
             </DistributedParameter>
-            <Container id="9Fe1IZB_tEKPcqvJAmybMA" name="Plasma" mode="Physical" containerType="Compartment">
+            <Container id="jkTc5JbBPkGr-ZHYsEDFfg" name="Plasma" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="Spleen" />
               </Tags>
               <Children>
-                <Parameter id="ThafaijM1UC7bsZn1Rfl0Q" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
-                  <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
-                </Parameter>
-                <Parameter id="pmS2SNcAhUqjNF5QJ1PcEA" name="FcRn concentration in container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.FcRn_in_Container_Plasma" isDefault="1" displayUnit="µmol/l">
+                <Parameter id="6i8af7IOak2ooRAcGwu3Vg" name="FcRn concentration in container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.FcRn_in_Container_Plasma" isDefault="1" displayUnit="µmol/l">
                   <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                   <Info flag="52" seq="1" ref="0" bb="2" group="25" />
                 </Parameter>
-                <Parameter id="KIjjLl_Bv0CMOhhZj55NGg" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_pls_2Pores" isDefault="1" displayUnit="l">
+                <Parameter id="mRNBu7hm0kC0e3coVY2mfw" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                  <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                </Parameter>
+                <Parameter id="jj_1y87OMU21JstW3OfUtg" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_pls_2Pores" isDefault="1" displayUnit="l">
                   <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                   <Info min="0" flag="62" seq="24" ref="0" bb="2" group="126" />
                 </Parameter>
-                <Container id="sOfO0Oyi7USqPQW5_f9JBA" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="X00t3nV5gkSk0UD6KU6G9Q" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                   <Children>
-                    <Parameter id="9a9jrKSRn0OnfZBHN3MGYw" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Plasma_and_Interstitial" isDefault="1" displayUnit="µmol/l">
+                    <Parameter id="DiVb--oRyUSQHCyv0Dx8LQ" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Plasma_and_Interstitial" isDefault="1" displayUnit="µmol/l">
                       <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                       <Info flag="52" seq="1" ref="0" bb="2" group="25" />
                     </Parameter>
-                    <Parameter id="6v7a5wnus0KNDYG_hOLh2Q" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                    <Parameter id="ZyYbLBrxBEqF351l5P-qHQ" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                     </Parameter>
-                    <Parameter id="rF48eYHac0Oe3eBEH1GKrg" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" isDefault="1">
+                    <Parameter id="Z75rZq98yUWtZWY4vV0JHg" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                     </Parameter>
-                    <Parameter id="SJBv2wmcUkKqVrPKP0Dddg" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
+                    <Parameter id="aqhokbPk10a6kzxR8DbAvA" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
                       <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                     </Parameter>
                   </Children>
                 </Container>
               </Children>
             </Container>
-            <Container id="09bGeC4CvkWoBzLgbyrP4g" name="BloodCells" mode="Physical" containerType="Compartment">
+            <Container id="L_KVwSudLEGk42Q8mLUZ1Q" name="BloodCells" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="Spleen" />
               </Tags>
               <Children>
-                <Parameter id="88vMEqKWBEeC8lLZxJ1SZQ" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                <Parameter id="-ge6MvgCH0KTej9GfJVM-Q" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
                   <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                 </Parameter>
-                <Parameter id="_fivsWmYnECGzCIefaApaA" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_bc_2Pores" isDefault="1" displayUnit="l">
+                <Parameter id="S-DQKhI10k2j_FLSz0ZEyQ" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_bc_2Pores" isDefault="1" displayUnit="l">
                   <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                   <Info min="0" flag="62" seq="24" ref="0" bb="2" group="121" />
                 </Parameter>
-                <Container id="M0_1mUbjxkS2FwQcKXCByw" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="97ivPaNYD0aWOjEH-ZSkiA" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                   <Children>
-                    <Parameter id="N31lyv0ChUS6QFJIAw6zhg" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                    <Parameter id="WeXVJm9ae0mnJKOF4uR4ew" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                     </Parameter>
-                    <Parameter id="J4-nrKLa30uaP8qPGIDQlw" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" isDefault="1">
+                    <Parameter id="iLuY6vQLM0m6zZqd2ipqMw" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                     </Parameter>
-                    <Parameter id="AExzDXvIc0Gv6mlgEgki_w" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
+                    <Parameter id="cnnPxV7sKkW4uUUBmjMyVw" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
                       <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                     </Parameter>
                   </Children>
                 </Container>
               </Children>
             </Container>
-            <Container id="dUGq5smYp02DPmodznUV4A" name="Interstitial" mode="Physical" containerType="Compartment">
+            <Container id="5WIKRUNL402_dIB3czf98g" name="Interstitial" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="Spleen" />
               </Tags>
               <Children>
-                <Parameter id="GQ-YRkdzEES3DEinD6r7Ig" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
-                  <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
-                </Parameter>
-                <Parameter id="hLT4btrgU02O6fFvuT9LxA" name="FcRn concentration in container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.FcRn_in_Container_Interstitial" isDefault="1" displayUnit="µmol/l">
+                <Parameter id="IoDlDyNHxk6Oj9b4arRPJA" name="FcRn concentration in container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.FcRn_in_Container_Interstitial" isDefault="1" displayUnit="µmol/l">
                   <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                   <Info flag="52" seq="1" ref="0" bb="2" group="25" />
                 </Parameter>
-                <Parameter id="MCrFh1tuYESu71k4B_Vdsg" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_int_2Pores" isDefault="1" displayUnit="l">
+                <Parameter id="G9YVXb61ekunXUW8oW-mmA" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                  <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                </Parameter>
+                <Parameter id="BYsKIsJhrk6t44czhWo7Zg" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_int_2Pores" isDefault="1" displayUnit="l">
                   <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                   <Info min="0" flag="62" seq="24" ref="0" bb="2" group="124" />
                 </Parameter>
-                <Parameter id="B4L5JuVeY0SJmezUDf7XPA" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_pH_INT" isDefault="1">
+                <Parameter id="AbATSAiAOEi7dWx2vGfCsg" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_pH_INT" isDefault="1">
                   <Tags>
                     <Tag value="Portal Vein Supplying Organ" />
                     <Tag value="Spleen" />
                   </Tags>
                   <Info min="0" max="14" flag="122" seq="74" ref="0" bb="32" group="84" />
                 </Parameter>
-                <Container id="bolkR2uuXEOpBti7yCfQRA" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="TPVdUgZ9W0SXPhDIWiJlRg" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                   <Children>
-                    <Parameter id="la2iseLy_UOQp8GfXvoTog" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Plasma_and_Interstitial" isDefault="1" displayUnit="µmol/l">
+                    <Parameter id="MwjB2mMZsUCdtgXjrbjf8g" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Plasma_and_Interstitial" isDefault="1" displayUnit="µmol/l">
                       <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                       <Info flag="52" seq="1" ref="0" bb="2" group="25" />
                     </Parameter>
-                    <Parameter id="Af4Us5aahUiBxpjlkl2yMA" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                    <Parameter id="JOEsu52plUGUo2cfRyjwrQ" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                     </Parameter>
-                    <Parameter id="32G9TZsT-0yohD_aRj1i7g" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_spl" isDefault="1">
+                    <Parameter id="69qfLU4T0EK1U-N4bOV_bA" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_spl" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                     </Parameter>
-                    <Parameter id="9kggC6g9gk6c-6wN9OgReQ" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
+                    <Parameter id="jkp7kct3y0O7_Lzccx-hRg" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
                       <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                     </Parameter>
                   </Children>
                 </Container>
               </Children>
             </Container>
-            <Container id="hcROPsJqIE-fUXIu9z8Iqw" name="Intracellular" mode="Physical" containerType="Compartment">
+            <Container id="wuBnciIuSUGPD6xYPo--vA" name="Intracellular" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="Spleen" />
               </Tags>
               <Children>
-                <Parameter id="RGSxEbb5nkSD7CEww8HlAg" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" isDefault="1" displayUnit="l">
+                <Parameter id="7JNymjbhjUGPdyrkM8L-og" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" isDefault="1" displayUnit="l">
                   <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                 </Parameter>
-                <Parameter id="pMPFl-h1QU2yzDx7y9Z48A" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_cell_2Pores" isDefault="1" displayUnit="l">
+                <Parameter id="pDbI8VYCt0enjj_x_83qGQ" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_cell_2Pores" isDefault="1" displayUnit="l">
                   <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                   <Info min="0" flag="62" seq="24" ref="0" bb="2" group="125" />
                 </Parameter>
-                <Parameter id="nG1yLZXwoEu_zVqYL84x2w" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7">
+                <Parameter id="0L8twL2fr0ePbn6eScr3RQ" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7">
                   <Tags>
                     <Tag value="Portal Vein Supplying Organ" />
                     <Tag value="Spleen" />
@@ -15921,52 +15994,52 @@
                   <ValueOrigin id="34" source="Publication" description="Toxicol In Vitro. 2008 Mar;22(2):457-67 https://doi.org/10.1016/j.tiv.2007.09.010" />
                   <Info min="0" max="14" flag="122" seq="74" ref="0" bb="32" group="83" />
                 </Parameter>
-                <Container id="ksLMO3iYD0CG-_5Ap8WuyA" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="5mXAzzSU0EOPjjRBkVx3Dg" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                   <Children>
-                    <Parameter id="KxH0fepw8USIfGj-N7FN9w" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                    <Parameter id="Ulr81dae0Eu8bIxarzhurg" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                     </Parameter>
-                    <Parameter id="eVWdeUhRPUyAZrQcbO6KIA" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_spl" isDefault="1">
+                    <Parameter id="EyD962t8XkaLfK_t6iP1-Q" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_spl" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                     </Parameter>
-                    <Parameter id="c_WOZ6bd-E-gZVk3XOChYg" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
+                    <Parameter id="PxKEM5jG4Eay76wJ_SrIuw" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
                       <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                     </Parameter>
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                 </Container>
               </Children>
             </Container>
-            <Container id="ztar9rDAak-m6S6ACVkMkQ" name="Endosome" mode="Physical" containerType="Compartment">
+            <Container id="rIsOdJNcdUG9BZnPvWtnbA" name="Endosome" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="Spleen" />
               </Tags>
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-                <Parameter id="adKbGYCKbUyr29VuG7YQyA" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
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+                <Parameter id="gvMaZg1jT02nbM6HqWaxWw" name="FcRn concentration in container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.FcRn_in_Container_Endosomal" isDefault="1" displayUnit="µmol/l">
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+                <Parameter id="-I2kyNdRGEGOpRBxWc05yw" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
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+                </Parameter>
+                <Parameter id="iApYJF6MnkOtJ8gQlY729w" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_end_spl" isDefault="1" displayUnit="l">
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-                <Container id="y7EbTO3rHky8UAcql8dXlA" name="MoleculeProperties" mode="Logical" containerType="Molecule">
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+                    <Parameter id="hg8SfzJiJkujq0rDTEO8Eg" name="Kd (FcRn) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_in_Container_Endosomal" isDefault="1" displayUnit="µmol/l">
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+                    <Parameter id="xaxIEGqeHkSxkTkbxxb9qw" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
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+                    <Parameter id="q34-3JUDFEWkw1xKqSpWcA" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
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+                    <Parameter id="Mb4FEpT74EGPOGoXm-QwBg" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
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@@ -15975,258 +16048,258 @@
             </Container>
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-        <Container id="roKu4GHkbUGXrDjFFDytQA" name="EndogenousIgG" mode="Logical" containerType="Organ">
+        <Container id="OhvJ2LOtfUW1P8UZ-OFbxQ" name="EndogenousIgG" mode="Logical" containerType="Organ">
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+            <Parameter id="NYrjbb7Pnk6KH4TENzT9Sg" name="f_membrane_int" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_F_Mem_INT" isDefault="1">
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+            <Parameter id="91f1zHfc2kGcDOr1b-iTeg" name="f_membrane_pls" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_F_Mem_PLS" isDefault="1">
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+            <Parameter id="Ot-W3BOUpEicOqXboVYuqA" name="Fraction of endosomal uptake from plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_uptake_vas" isDefault="1">
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+            <Parameter id="iU91HDEmc0Oyq8SNz3FhBg" name="krint" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_krint" isDefault="1" displayUnit="l/min">
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+            <Parameter id="TMT_c8p5IEaT7E2PERjHnQ" name="Fraction recycled to plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.PARAM_f_rec_vas" isDefault="1">
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-            <Container id="7y0uknsa4E-rfc1F2Z5tQA" name="Endosome" mode="Physical" containerType="Compartment">
+            <Container id="agzD72z7DEqnZcYFQ79ngg" name="Endosome" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="Endogenous_IgG" />
               </Tags>
               <Children>
-                <Parameter id="2bm5zbXI4Uu29GfHyp2Pbg" name="Kd (FcRn, endogenous IgG) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_LigandEndo_in_Container_Endosomal" isDefault="1" displayUnit="µmol/l">
+                <Parameter id="Cvv7uPMZHU2JrzW92ie-jA" name="Kd (FcRn, endogenous IgG) in endosomal space of container" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="EndosomalSpaceBindingFormulas.KdFcRn_LigandEndo_in_Container_Endosomal" isDefault="1" displayUnit="µmol/l">
                   <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                   <Info flag="52" seq="1" ref="0" bb="2" group="25" />
                 </Parameter>
-                <Parameter id="1k1BgUIZyEqS7xeCjwn0eg" name="Specific endosomal clearance" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="SpecificClearance_PKSim.PARAM_CLSpec_endosomal" isDefault="1" displayUnit="1/min">
+                <Parameter id="Rp8pL8-SG06ddVMohwCKKw" name="Specific endosomal clearance" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="SpecificClearance_PKSim.PARAM_CLSpec_endosomal" isDefault="1" displayUnit="1/min">
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                 </Parameter>
-                <Parameter id="cI_dRP6XxEioOhKqXzsHTQ" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_end_ecl" isDefault="1" displayUnit="l">
+                <Parameter id="Feq35fkbCkuQXjybgk9m8A" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_end_ecl" isDefault="1" displayUnit="l">
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                   <Info min="0" flag="62" seq="25" ref="0" bb="2" group="123" />
                 </Parameter>
-                <Parameter id="7T52zQY_Sky9NI-eM28vig" name="Start concentration of free FcRn (endosome)" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="80.8" displayUnit="µmol/l">
+                <Parameter id="kL598G6-G02RB-R1wTcSqg" name="Start concentration of free FcRn (endosome)" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="80.8" displayUnit="µmol/l">
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                     <Tag value="Endogenous_IgG" />
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                 </Parameter>
-                <Container id="qnfw4jVPtkSrGTcQw_IStQ" name="MoleculeProperties" mode="Logical" containerType="Molecule" />
+                <Container id="MUhkWP50y0m_3DVr_e3x7A" name="MoleculeProperties" mode="Logical" containerType="Molecule" />
               </Children>
             </Container>
-            <Container id="2kLO2rZsFU6ORv3GlfLi-w" name="IgG_Source" mode="Physical" containerType="Compartment">
+            <Container id="QhXFNRAUBUGAOtpHhUG9Qg" name="IgG_Source" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="Endogenous_IgG" />
               </Tags>
               <Children>
-                <Parameter id="dfWbksaXGU6MsfiLI_-qHg" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="l">
+                <Parameter id="0GUagOrqok-APbt4EWILYw" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="l">
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                 </Parameter>
-                <Container id="vU6gtiT0o0uWfaQKQwQx_Q" name="MoleculeProperties" mode="Logical" containerType="Molecule" />
+                <Container id="FCpJ9_VYFkqtbHVfo5sxBQ" name="MoleculeProperties" mode="Logical" containerType="Molecule" />
               </Children>
             </Container>
-            <Container id="PVsE91ttqUaGpEkv6S3jdg" name="EndosomalClearance" mode="Physical" containerType="Compartment">
+            <Container id="g2-FoiUD-EWvaNY_ICtKKA" name="EndosomalClearance" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="Endogenous_IgG" />
               </Tags>
               <Children>
-                <Parameter id="Cf6Psr_ml0--n-7pb0o_Lw" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="l">
+                <Parameter id="ypmkn-aGgk-xPQP_P2PO5g" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="l">
                   <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="122" />
                 </Parameter>
@@ -16234,56 +16307,56 @@
             </Container>
           </Children>
         </Container>
-        <Container id="7ZegLC31E0-osRRvfPWeRg" name="Saliva" mode="Logical" containerType="Organ">
+        <Container id="jRgNYrzTgUay8lA8ZizVxA" name="Saliva" mode="Logical" containerType="Organ">
           <Children>
-            <Parameter id="B_evhYpzWEKHrceet03DTw" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
+            <Parameter id="dfJz4qoWk0G_K_DLpyQuLQ" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
               <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
             </Parameter>
-            <Parameter id="W7w4N8DkMUOY6oo7A9TOiQ" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.VOLUME_Saliva_Organ" isDefault="1" displayUnit="l">
+            <Parameter id="AwoPKkHiqEO8Zq_7JL3XlQ" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.VOLUME_Saliva_Organ" isDefault="1" displayUnit="l">
               <ValueOrigin id="43" source="Internet" description="Willi Cawello. Pharmacokinetics and bioavailability derived from various body fluids. http://www.agah.eu/fileadmin/_migrated/content_uploads/W._Cawello__2__25.05.07.pdf" />
               <Info min="0" flag="122" seq="14" ref="0" bb="32" group="65" />
             </Parameter>
-            <Parameter id="CTB1c3FxjkqC7V5KXG-30w" name="Saliva flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.001" displayUnit="l/min">
+            <Parameter id="CivJ-awvkU-lLbdcdOG5Ng" name="Density (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
+              <Info min="0" flag="38" seq="1" ref="0" bb="32" group="21" />
+            </Parameter>
+            <Parameter id="cpLs0mjClUuOpHPGTKbIwA" name="Saliva flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.001" displayUnit="l/min">
               <ValueOrigin id="43" source="Internet" description="Willi Cawello. Pharmacokinetics and bioavailability derived from various body fluids. http://www.agah.eu/fileadmin/_migrated/content_uploads/W._Cawello__2__25.05.07.pdf" />
               <Info min="0.0001" max="0.01" flag="122" seq="1" ref="0" bb="32" group="93" />
             </Parameter>
-            <Parameter id="9TXMEXOGXUKZ5eYjtv7cqQ" name="Density (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
-              <Info min="0" flag="38" seq="1" ref="0" bb="32" group="21" />
-            </Parameter>
-            <Container id="vPFJuXlB4kCa_JiNyQJJEA" name="Saliva" mode="Physical" containerType="Compartment">
+            <Container id="_9S60KhEy0yRP_yGh25V1g" name="Saliva" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="Saliva" />
               </Tags>
               <Children>
-                <Parameter id="tTndYGUkF0Wk8ohxaPyWkA" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_slv_slv" isDefault="1" displayUnit="l">
+                <Parameter id="-j8GnbeWUkm5--2sEsAbmg" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_slv_slv" isDefault="1" displayUnit="l">
                   <Info min="0" flag="54" seq="666" ref="0" bb="2" group="65" />
                 </Parameter>
-                <Parameter id="g8-AFGSY10iL6K-XG6OAGw" name="pH (saliva)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.4">
+                <Parameter id="VEv3ouvgDUaBJHC06SYv5w" name="pH (saliva)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.4">
                   <Tags>
                     <Tag value="Saliva" />
                   </Tags>
                   <ValueOrigin id="43" source="Internet" description="Willi Cawello. Pharmacokinetics and bioavailability derived from various body fluids. http://www.agah.eu/fileadmin/_migrated/content_uploads/W._Cawello__2__25.05.07.pdf" />
                   <Info min="0" max="14" flag="122" seq="1" ref="0" bb="32" group="82" />
                 </Parameter>
-                <Container id="Nr-an76-VU-bHvJw5zhDTA" name="MoleculeProperties" mode="Logical" containerType="Molecule" />
+                <Container id="MrznXOWCjkOZNX05IZ8wAg" name="MoleculeProperties" mode="Logical" containerType="Molecule" />
               </Children>
             </Container>
-            <Container id="kVddIOjBn0CZ1HvUQU3eag" name="SalivaGland" mode="Physical" containerType="Compartment">
+            <Container id="E0C1FOep8k2IcmAYnuEQ6w" name="SalivaGland" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="Saliva" />
               </Tags>
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+                <Parameter id="lr1yV73VaEaQEMHWHBM-ig" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_2Poren.VOLUME_slv_slv" isDefault="1" displayUnit="l">
                   <Info min="0" flag="54" seq="666" ref="0" bb="2" group="65" />
                 </Parameter>
-                <Container id="CiVucDBPI0O4qcTVUpb29A" name="MoleculeProperties" mode="Logical" containerType="Molecule" />
+                <Container id="xCEHG26qaU-LNg-LiS_BOQ" name="MoleculeProperties" mode="Logical" containerType="Molecule" />
               </Children>
             </Container>
           </Children>
         </Container>
-        <Container id="eDJJFajIZ0qqc5SSL9V05w" name="EndosomalClearance" mode="Physical" containerType="Compartment">
+        <Container id="0MjJnhA0s063jmqn9J-j4Q" name="EndosomalClearance" mode="Physical" containerType="Compartment">
           <Children>
-            <Parameter id="h2KxNzwbu02x2twQZhFA4g" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="l">
+            <Parameter id="hUtoGpS3w0CQhYcS26F7Cg" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="l">
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               <Info min="0" flag="54" seq="1" ref="0" bb="2" group="122" />
             </Parameter>
@@ -16291,25 +16364,33 @@
         </Container>
       </Children>
     </Container>
-    <Container id="Fe-4MCOqN068rLD--5FBmA" name="Events" mode="Logical" containerType="Other" />
+    <Container id="_NPSUpGpe0Wj4fiOHoyG9Q" name="Events" mode="Logical" containerType="Other" />
   </TopContainers>
-  <NeighborhoodsContainer id="Fu8yxbsgU0OjSKJsiyqPmQ" name="Neighborhoods" mode="Logical" containerType="Other">
+  <NeighborhoodsContainer id="iCbNTicuCUWQ1sTVeCwaHg" name="Neighborhoods" mode="Logical" containerType="Other">
     <Children>
-      <NeighborhoodBuilder id="Z1LGcc2Vs0-5aHCiUV7NLA" name="VenousBlood_bc_Lung_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="BvN_npw9ekupr6uHYGaj_g" secondNeighbor="zsldzYW4pk-M1HRwOQZvjA">
+      <NeighborhoodBuilder id="Ri698wPTzEyfBb4HJTTucQ" name="VenousBlood_bc_Lung_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="s69zFizy-UefsPiLLFllaw" secondNeighbor="nHn8QNvAq0SNQaYeoYdZgA">
         <Tags>
           <Tag value="Neighborhood: BloodCells / BloodCells" />
         </Tags>
         <Children>
-          <Container id="QJ6G3p_Xt0adjMPBA9G1_A" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="RjvE_QbnBE2QrgBF5OBLsA" name="MoleculeProperties" mode="Logical" containerType="Other" />
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="JB70eT4BcUmlLl4_swAcow" name="VenousBlood_pls_Lung_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="JxP9aCWtgUGhXH_R7w1Z2Q" secondNeighbor="t6OBxd-hCkCODe51LaKiww">
+        <Tags>
+          <Tag value="Neighborhood: Plasma / Plasma" />
+        </Tags>
+        <Children>
+          <Container id="ZpNTpYZKEUCuwxdkE-E4uA" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="cScIePhzqEGGWwP_D71TjA" name="VenousBlood_pls_VenousBlood_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="lg3JPjAHSUaKoE7vwc_rTw" secondNeighbor="BvN_npw9ekupr6uHYGaj_g">
+      <NeighborhoodBuilder id="5LAX1GK9NE2g2a1jdlmpig" name="VenousBlood_pls_VenousBlood_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="JxP9aCWtgUGhXH_R7w1Z2Q" secondNeighbor="s69zFizy-UefsPiLLFllaw">
         <Tags>
           <Tag value="Neighborhood: Plasma / BloodCells" />
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-          <Container id="KD2cIApIcUCoO-6KPXHzYg" name="MoleculeProperties" mode="Logical" containerType="Other" />
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+          <Container id="MLbf4MS-H0mOFhhuKpZ3bg" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Parameter id="P2bc_v-U00W2hSWUim5MNA" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls_Blood_Organ" isDefault="1" displayUnit="cm²">
             <Tags>
               <Tag value="Neighborhood: Plasma / BloodCells" />
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@@ -16317,21 +16398,13 @@
           </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="2a24ny-qZ0Sst-MBZNHjGQ" name="VenousBlood_pls_Lung_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="lg3JPjAHSUaKoE7vwc_rTw" secondNeighbor="4kCl377ujkOzqrUFkOXeCg">
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+      <NeighborhoodBuilder id="FbLGpRczmUKjtv_A9lha4g" name="ArterialBlood_pls_ArterialBlood_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="8w_HEBIvlUCHJDlw_MvzWw" secondNeighbor="IhEBMJxutUm85iXU4_r5iQ">
         <Tags>
           <Tag value="Neighborhood: Plasma / BloodCells" />
         </Tags>
         <Children>
-          <Container id="qiXTvk5jOUCOd6qPaPUNTw" name="MoleculeProperties" mode="Logical" containerType="Other" />
-          <Parameter id="0U2gJ4z50UWolkMIFJDh5Q" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls_Blood_Organ" isDefault="1" displayUnit="cm²">
+          <Container id="QzYhuT_W_0GUMxXybrf-Kw" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Parameter id="7SqK5bIieU-uZCoFOGVPvw" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls_Blood_Organ" isDefault="1" displayUnit="cm²">
             <Tags>
               <Tag value="Neighborhood: Plasma / BloodCells" />
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@@ -16339,85 +16412,150 @@
           </Parameter>
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       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="Cq9CiQJlvEi5zXJGeEooUQ" name="Bone_pls_Bone_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="J_R45u2jY0aQ6OB94raJMw" secondNeighbor="0ZeiM2zSzUGGXNWRJFkmdg">
+      <NeighborhoodBuilder id="LonZ6dv0Ok6IQs-bePbffg" name="Bone_bc_VenousBlood_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="tJw6KPhGIEaErEmBaHPOEQ" secondNeighbor="s69zFizy-UefsPiLLFllaw">
         <Tags>
-          <Tag value="Neighborhood: Plasma / BloodCells" />
+          <Tag value="Neighborhood: BloodCells / BloodCells" />
+        </Tags>
+        <Children>
+          <Container id="WVKW9JN0ykCDw-3FNLp2lg" name="MoleculeProperties" mode="Logical" containerType="Other" />
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="Jov0LIXgmEWBKz2LFAddIA" name="Bone_end_Bone_ecl" mode="Logical" containerType="Neighborhood" firstNeighbor="M_opIWAYvke3PQqeQDkFjA" secondNeighbor="0MjJnhA0s063jmqn9J-j4Q">
+        <Tags>
+          <Tag value="Neighborhood: Endosome / EndosomalClearance" />
+        </Tags>
+        <Children>
+          <Container id="NnC6ZPMjAkSWSUMFcshFSg" name="MoleculeProperties" mode="Logical" containerType="Other" />
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="AjBwlSEO-kCGWUZINtP9uw" name="Bone_end_Bone_int" mode="Logical" containerType="Neighborhood" firstNeighbor="M_opIWAYvke3PQqeQDkFjA" secondNeighbor="QA9FHIK55U2W76f1KdtDtg">
+        <Tags>
+          <Tag value="Neighborhood: Endosome / Interstitial" />
+        </Tags>
+        <Children>
+          <Container id="G1kKrBiniE-vrGoaTdgjOA" name="MoleculeProperties" mode="Logical" containerType="Other" />
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="7zC1jfdrAkC0j0W3Cu7I0w" name="Bone_int_Bone_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="QA9FHIK55U2W76f1KdtDtg" secondNeighbor="6VIi3P6bpU6zGQUGR8cXuQ">
+        <Tags>
+          <Tag value="Neighborhood: Interstitial / Intracellular" />
         </Tags>
         <Children>
-          <Container id="ZqszN2idNkqjN_TtOaBbcQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
-          <Parameter id="_R-2pbVO_EmQWeB_8xcFEQ" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" isDefault="1" displayUnit="cm²">
+          <Container id="tmj21kVYTk2rqX5LYW4mRA" name="MoleculeProperties" mode="Logical" containerType="Other">
+            <Children>
+              <Parameter id="xaRxJaB6sUu8C9TEV_Qp6g" name="P (interstitial-&gt;intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" isDefault="1" displayUnit="cm/min">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="78" />
+              </Parameter>
+              <Parameter id="WW4JnUR97EqkDW3zYVw5NA" name="P (intracellular-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" isDefault="1" displayUnit="cm/min">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="76" />
+              </Parameter>
+              <Parameter id="9s8TtBuCtEuIYm4_lFdsNQ" name="P*SA interstitial -&gt; intracellular" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" isDefault="1" displayUnit="l/min">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="w73y1U3cYEO8ht8pF8aJOA" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="PRRfz8Dq70OkF3OFcpdG4Q" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="UE1q3-gZkEKfUeJuSynyvA" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="6nWZDqu_b0iMl5ZzNXkihw" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="69" />
+              </Parameter>
+              <Parameter id="FQMtXUZaWUm4bhJKHl2LfQ" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+              </Parameter>
+            </Children>
+          </Container>
+          <Parameter id="dMub-AP6LkuxmeSmrgRB2Q" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_bon" isDefault="1" displayUnit="cm²">
             <Tags>
-              <Tag value="Neighborhood: Plasma / BloodCells" />
+              <Tag value="Neighborhood: Interstitial / Intracellular" />
             </Tags>
-            <Info min="0" flag="122" seq="3" ref="0" bb="32" group="104" />
+            <Info min="0" flag="122" seq="1" ref="0" bb="32" group="105" />
           </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="HxKqCafW8EG-rDyFrLmLzw" name="Bone_bc_VenousBlood_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="0ZeiM2zSzUGGXNWRJFkmdg" secondNeighbor="BvN_npw9ekupr6uHYGaj_g">
+      <NeighborhoodBuilder id="LVU4FsEbX0G-Rh4izDz5TQ" name="Bone_int_VenousBlood_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="QA9FHIK55U2W76f1KdtDtg" secondNeighbor="JxP9aCWtgUGhXH_R7w1Z2Q">
         <Tags>
-          <Tag value="Neighborhood: BloodCells / BloodCells" />
+          <Tag value="Neighborhood: Interstitial / Plasma" />
         </Tags>
         <Children>
-          <Container id="ToTQchn_eUa64VsulKDoXg" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="9HEk991KJUyZdiVldUCXkQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="XEQEAUvJ-EyRjqS1MDpsiQ" name="Bone_end_Bone_int" mode="Logical" containerType="Neighborhood" firstNeighbor="aJAbJim65USIdVbYSsUytw" secondNeighbor="hhWYeEpr4EaarG7RaRsw4g">
+      <NeighborhoodBuilder id="HF7sdWaAjUitrY_H1uPX4Q" name="Bone_pls_Bone_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="fusuTlSi4kCVIX7JKRrMwg" secondNeighbor="tJw6KPhGIEaErEmBaHPOEQ">
         <Tags>
-          <Tag value="Neighborhood: Endosome / Interstitial" />
+          <Tag value="Neighborhood: Plasma / BloodCells" />
+        </Tags>
+        <Children>
+          <Container id="2jdir-M_Lk-DldssMnc19w" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Parameter id="v7mKXQrAdEScGO5KZLvgKg" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" isDefault="1" displayUnit="cm²">
+            <Tags>
+              <Tag value="Neighborhood: Plasma / BloodCells" />
+            </Tags>
+            <Info min="0" flag="122" seq="3" ref="0" bb="32" group="104" />
+          </Parameter>
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="y0vYslMriUiX6fILHFiCGA" name="Bone_pls_Bone_end" mode="Logical" containerType="Neighborhood" firstNeighbor="fusuTlSi4kCVIX7JKRrMwg" secondNeighbor="M_opIWAYvke3PQqeQDkFjA">
+        <Tags>
+          <Tag value="Neighborhood: Plasma / Endosome" />
         </Tags>
         <Children>
-          <Container id="sHvJpWyZMUOPmtIRmoP3vg" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="3A-OEjaQ2kmbdlT7wR7unQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="tc7tcML_YEykuEKHZgZs_Q" name="Bone_pls_Bone_int" mode="Logical" containerType="Neighborhood" firstNeighbor="J_R45u2jY0aQ6OB94raJMw" secondNeighbor="hhWYeEpr4EaarG7RaRsw4g">
+      <NeighborhoodBuilder id="OUP_xBmvOUW-O36X5_afYQ" name="Bone_pls_Bone_int" mode="Logical" containerType="Neighborhood" firstNeighbor="fusuTlSi4kCVIX7JKRrMwg" secondNeighbor="QA9FHIK55U2W76f1KdtDtg">
         <Tags>
           <Tag value="Neighborhood: Plasma / Interstitial" />
         </Tags>
         <Children>
-          <Container id="IL3bWpzDQkCQTD6wqrcggA" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="XDt6ybKVMEyMTGQr4J1XNA" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="yUGzA8T4KEGflMgXwpsM9A" name="P (small endothelial pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial_s" isDefault="1" displayUnit="cm/min">
+              <Parameter id="eZAJ94x02kOch8evm-RFBA" name="P (large endothelial pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial_l" isDefault="1" displayUnit="cm/min">
                 <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="80" />
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="79" />
               </Parameter>
-              <Parameter id="X_3EQ8wScU--vsZUo3fNFA" name="P (plasma&lt;-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial" isDefault="1" displayUnit="cm/min">
+              <Parameter id="TAXB93nM_0alqYKc92-p8g" name="P (plasma&lt;-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial" isDefault="1" displayUnit="cm/min">
                 <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="77" />
               </Parameter>
-              <Parameter id="DrV4E4-QU0SXUjTHyZ6Uew" name="P (large endothelial pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial_l" isDefault="1" displayUnit="cm/min">
+              <Parameter id="fagvpA1oR06rk31_2ysV8Q" name="P (small endothelial pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial_s" isDefault="1" displayUnit="cm/min">
                 <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="79" />
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="80" />
+              </Parameter>
+              <Parameter id="SFJxJKlwWkeyTYQrvQKqIg" name="Partition coefficient (interstitial/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" isDefault="1">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="70" />
               </Parameter>
-              <Parameter id="QDU8pfllS0OwTAecWe2pFQ" name="Peclet number (large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CalcPecletNumber.PecletNumber_l" isDefault="1">
+              <Parameter id="5TM2QgNxBE-CjJTF8k0i2g" name="Peclet number (large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CalcPecletNumber.PecletNumber_l" isDefault="1">
                 <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="116" />
               </Parameter>
-              <Parameter id="7PLobofxI0aLKA1-pg5IMQ" name="Peclet number (small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CalcPecletNumber.PecletNumber_s" isDefault="1">
+              <Parameter id="SoDNn_a50E67_ms73TiqAw" name="Peclet number (small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CalcPecletNumber.PecletNumber_s" isDefault="1">
                 <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="116" />
               </Parameter>
-              <Parameter id="dvGZVBS24EiT8dsBqdSjDg" name="Partition coefficient (interstitial/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" isDefault="1">
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="70" />
-              </Parameter>
-              <Parameter id="Jn_XjP6EskO8Fl6e9DllVg" name="Reflection coefficient (small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_sigma_s" isDefault="1">
+              <Parameter id="oE0DGL0_ekmYFRBT4priYw" name="Radius ratio (solute/large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_gamma_l" isDefault="1">
                 <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-                <Info min="0" flag="58" seq="1" ref="0" bb="2" group="90" />
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="116" />
               </Parameter>
-              <Parameter id="-dP2Wv1pjEC0CWljvBTO8g" name="Reflection coefficient (large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_sigma_l" isDefault="1">
+              <Parameter id="tyUrh0wMEkiCbYhNUzpcpQ" name="Radius ratio (solute/small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_gamma_s" isDefault="1">
                 <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-                <Info min="0" flag="58" seq="1" ref="0" bb="2" group="89" />
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="116" />
               </Parameter>
-              <Parameter id="sThPuOzrfU2e_HuJuIfZyA" name="Radius ratio (solute/small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_gamma_s" isDefault="1">
+              <Parameter id="AWjN8A7j1EqUKuebf_XnVw" name="Reflection coefficient (large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_sigma_l" isDefault="1">
                 <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="116" />
+                <Info min="0" flag="58" seq="1" ref="0" bb="2" group="89" />
               </Parameter>
-              <Parameter id="9P-es63OOE20vPQU4mQcnw" name="Radius ratio (solute/large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_gamma_l" isDefault="1">
+              <Parameter id="khBj6kQwT0eTC8UHRguBiA" name="Reflection coefficient (small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_sigma_s" isDefault="1">
                 <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="116" />
+                <Info min="0" flag="58" seq="1" ref="0" bb="2" group="90" />
               </Parameter>
             </Children>
           </Container>
-          <Parameter id="aT-s4XTRh0--JGu2IyczSg" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" isDefault="1" displayUnit="cm²">
+          <Parameter id="LQeUaPwUNkKcI66GYeGA7A" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" isDefault="1" displayUnit="cm²">
             <Tags>
               <Tag value="Neighborhood: Plasma / Interstitial" />
             </Tags>
@@ -16426,136 +16564,158 @@
           </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="mrMrWwHTckuD2NtP1UNLrA" name="Bone_int_VenousBlood_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="hhWYeEpr4EaarG7RaRsw4g" secondNeighbor="lg3JPjAHSUaKoE7vwc_rTw">
+      <NeighborhoodBuilder id="alCopkQhZ02kXvHbI2CehQ" name="Bone_pls_VenousBlood_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="fusuTlSi4kCVIX7JKRrMwg" secondNeighbor="JxP9aCWtgUGhXH_R7w1Z2Q">
         <Tags>
-          <Tag value="Neighborhood: Interstitial / Plasma" />
+          <Tag value="Neighborhood: Plasma / Plasma" />
         </Tags>
         <Children>
-          <Container id="SdYyD8ihY0ORBvsfSEgo-Q" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="QdBUEtyDSkehd48p5ZZ4Zw" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="QZXhBtuS-ECkMone-wLBWg" name="Bone_pls_Bone_end" mode="Logical" containerType="Neighborhood" firstNeighbor="J_R45u2jY0aQ6OB94raJMw" secondNeighbor="aJAbJim65USIdVbYSsUytw">
+      <NeighborhoodBuilder id="HKUnVD0RF0GYzKZ9epa5cA" name="Brain_bc_VenousBlood_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="FzwVGKYCd0-Uc9UyHkA0hQ" secondNeighbor="s69zFizy-UefsPiLLFllaw">
         <Tags>
-          <Tag value="Neighborhood: Plasma / Endosome" />
+          <Tag value="Neighborhood: BloodCells / BloodCells" />
+        </Tags>
+        <Children>
+          <Container id="QWweSt8WlUGaUmlBmyrtsg" name="MoleculeProperties" mode="Logical" containerType="Other" />
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="irklh8JmvUi2yXXFoRLyXA" name="Brain_end_Brain_ecl" mode="Logical" containerType="Neighborhood" firstNeighbor="RUbr4e4oDUWZTVZF-N710A" secondNeighbor="0MjJnhA0s063jmqn9J-j4Q">
+        <Tags>
+          <Tag value="Neighborhood: Endosome / EndosomalClearance" />
+        </Tags>
+        <Children>
+          <Container id="aQD0uViOa06rcPGco3FfeA" name="MoleculeProperties" mode="Logical" containerType="Other" />
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="uOzHp287GEC60tojKuQUbA" name="Brain_end_Brain_int" mode="Logical" containerType="Neighborhood" firstNeighbor="RUbr4e4oDUWZTVZF-N710A" secondNeighbor="VSZVl9fsKESrU01XtBOW5A">
+        <Tags>
+          <Tag value="Neighborhood: Endosome / Interstitial" />
         </Tags>
         <Children>
-          <Container id="QABw0P6KTkOfccZwwVhz3A" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="b7YDQcIZVkCi1Q-bVPMkiA" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="3VZKVqG3FEaIW8IpZap7Yg" name="Bone_int_Bone_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="hhWYeEpr4EaarG7RaRsw4g" secondNeighbor="vdXJTDdPLUWQgZa5_EHvfQ">
+      <NeighborhoodBuilder id="32VC5qGEFkKickFmY90tVA" name="Brain_int_Brain_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="VSZVl9fsKESrU01XtBOW5A" secondNeighbor="-SetkLXoakGgu8wV-vcpXg">
         <Tags>
           <Tag value="Neighborhood: Interstitial / Intracellular" />
         </Tags>
         <Children>
-          <Container id="6Jq-R_AxmUCAnm8kqGCEYw" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="NKC1UaVvfEe1kdSA2aYSng" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="07Nm9QS41kCZK2XJyVbcsQ" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+              <Parameter id="JpVFV14jLkuv1-wFcw7pHg" name="P (interstitial-&gt;intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" isDefault="1" displayUnit="cm/min">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="78" />
               </Parameter>
-              <Parameter id="F_a_r63NFk6yycnRvKM1pw" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+              <Parameter id="Eeu9uicDoUaC45-C_DSZFg" name="P (intracellular-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" isDefault="1" displayUnit="cm/min">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="76" />
               </Parameter>
-              <Parameter id="XRcZNioP3UapnM7nlT5jJw" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="69" />
+              <Parameter id="eYFs1NjZjEaX_l-DpZgJ2Q" name="P*SA interstitial -&gt; intracellular" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" isDefault="1" displayUnit="l/min">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="5GHiKYi6xEiWi5fZWbQprw" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
+              <Parameter id="38DSCjdmPUq8DsNSs1n6HA" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="Qz_55eMcy0uiwS8WWUxDlA" name="P*SA interstitial -&gt; intracellular" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" isDefault="1" displayUnit="l/min">
+              <Parameter id="8C3_tScw6k29MrCeWX6WOQ" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="nOBe1eSqmEGr1uH_Ap8Igg" name="P (intracellular-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" isDefault="1" displayUnit="cm/min">
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="76" />
+              <Parameter id="J5kOQyvF9USDSdy_MmGGtw" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="tV9nwtHqPE2jf3lo6sN51g" name="P (interstitial-&gt;intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" isDefault="1" displayUnit="cm/min">
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="78" />
+              <Parameter id="PLQNeP5sZUy3O7aynxo1hQ" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="69" />
               </Parameter>
-              <Parameter id="cppS3A4G0kmwfmyp6o-c9Q" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+              <Parameter id="eJQ2MH9a2U2U0v_MRf9Lmw" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
               </Parameter>
             </Children>
           </Container>
-          <Parameter id="QaMFXItgIk6yPZlxhx7Wgg" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_bon" isDefault="1" displayUnit="cm²">
+          <Parameter id="AunbPm5tyUaa0084qlQTQg" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_brn" isDefault="1" displayUnit="cm²">
             <Tags>
               <Tag value="Neighborhood: Interstitial / Intracellular" />
             </Tags>
-            <Info min="0" flag="122" seq="1" ref="0" bb="32" group="105" />
+            <Info min="0" flag="122" seq="2" ref="0" bb="32" group="105" />
           </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="t-GmyQlkg0i_nwNeEzt35g" name="Bone_end_Bone_ecl" mode="Logical" containerType="Neighborhood" firstNeighbor="aJAbJim65USIdVbYSsUytw" secondNeighbor="eDJJFajIZ0qqc5SSL9V05w">
+      <NeighborhoodBuilder id="BjXq1cJV3ESYgnjNi7lmOg" name="Brain_int_VenousBlood_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="VSZVl9fsKESrU01XtBOW5A" secondNeighbor="JxP9aCWtgUGhXH_R7w1Z2Q">
         <Tags>
-          <Tag value="Neighborhood: Endosome / EndosomalClearance" />
+          <Tag value="Neighborhood: Interstitial / Plasma" />
         </Tags>
         <Children>
-          <Container id="HtyB16SfDU607h8M6uS5Jw" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="ia5OzmRgqE-E6t06EhA4ug" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="jcjR1KXesUOZfpWrH_3yXA" name="Bone_pls_VenousBlood_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="J_R45u2jY0aQ6OB94raJMw" secondNeighbor="lg3JPjAHSUaKoE7vwc_rTw">
+      <NeighborhoodBuilder id="gaZ7IFLuwkWbiFbn6TSqWQ" name="Brain_pls_Brain_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="B3ppcgqIdE6xO8qFxNT7fw" secondNeighbor="FzwVGKYCd0-Uc9UyHkA0hQ">
         <Tags>
-          <Tag value="Neighborhood: Plasma / Plasma" />
+          <Tag value="Neighborhood: Plasma / BloodCells" />
         </Tags>
         <Children>
-          <Container id="1WibNJcCyEyjbKKmk492kQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="tF0nQdbgDEa5d2Wg1dPyJQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Parameter id="UJCUovz4pEuThHpLyRfK4g" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" isDefault="1" displayUnit="cm²">
+            <Tags>
+              <Tag value="Neighborhood: Plasma / BloodCells" />
+            </Tags>
+            <Info min="0" flag="122" seq="4" ref="0" bb="32" group="104" />
+          </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="VUgglqoDy0C51CTu03Mlyg" name="Brain_int_VenousBlood_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="shzol-gVH0yGf823UQaYvg" secondNeighbor="lg3JPjAHSUaKoE7vwc_rTw">
+      <NeighborhoodBuilder id="3J0zaH-ZsUCZfLojYJQCjg" name="Brain_pls_Brain_end" mode="Logical" containerType="Neighborhood" firstNeighbor="B3ppcgqIdE6xO8qFxNT7fw" secondNeighbor="RUbr4e4oDUWZTVZF-N710A">
         <Tags>
-          <Tag value="Neighborhood: Interstitial / Plasma" />
+          <Tag value="Neighborhood: Plasma / Endosome" />
         </Tags>
         <Children>
-          <Container id="hizxBlAG906aU--Xepi9uw" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="uzjkamoBl0euXVd5FkQp-A" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="UKfnhGCaO02dNevYi0iemg" name="Brain_pls_Brain_int" mode="Logical" containerType="Neighborhood" firstNeighbor="nHn-DlMwp0-NSpksuD5rxQ" secondNeighbor="shzol-gVH0yGf823UQaYvg">
+      <NeighborhoodBuilder id="TKkTAssQfkGdUjEddqCFkA" name="Brain_pls_Brain_int" mode="Logical" containerType="Neighborhood" firstNeighbor="B3ppcgqIdE6xO8qFxNT7fw" secondNeighbor="VSZVl9fsKESrU01XtBOW5A">
         <Tags>
           <Tag value="Neighborhood: Plasma / Interstitial" />
         </Tags>
         <Children>
-          <Container id="fJknMIBsOUit9UnyFxxfNw" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="nKOmW6segEWU1IGVBI19xg" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="CHI0ac8A1E-2GqR3CgwNIw" name="Radius ratio (solute/small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_gamma_s" isDefault="1">
+              <Parameter id="vM5f6ZLrsUWBbhq87x-7DQ" name="P (large endothelial pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial_l" isDefault="1" displayUnit="cm/min">
                 <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="116" />
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="79" />
               </Parameter>
-              <Parameter id="yhtdJQ33q0SC-UkllRtA5g" name="Reflection coefficient (small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_sigma_s" isDefault="1">
+              <Parameter id="1iW-6fyrgUSzy-b_z5Zr1Q" name="P (plasma&lt;-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial" isDefault="1" displayUnit="cm/min">
                 <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-                <Info min="0" flag="58" seq="1" ref="0" bb="2" group="90" />
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="77" />
               </Parameter>
-              <Parameter id="wvkOB4XlmUSeD1pc63g4zw" name="Radius ratio (solute/large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_gamma_l" isDefault="1">
+              <Parameter id="qTZI3_SsI0OMtJieEXA6dg" name="P (small endothelial pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial_s" isDefault="1" displayUnit="cm/min">
                 <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="116" />
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="80" />
               </Parameter>
-              <Parameter id="MUsk6zkunkyh8qZ6-lQotg" name="Reflection coefficient (large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_sigma_l" isDefault="1">
-                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-                <Info min="0" flag="58" seq="1" ref="0" bb="2" group="89" />
+              <Parameter id="jrokeXKSck6m-OqnD3wRzg" name="Partition coefficient (interstitial/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" isDefault="1">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="70" />
               </Parameter>
-              <Parameter id="QiEvenktbEKQea1u744B9Q" name="Peclet number (small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CalcPecletNumber.PecletNumber_s" isDefault="1">
+              <Parameter id="ZUWQkZNts0q5--utGAgPKg" name="Peclet number (large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CalcPecletNumber.PecletNumber_l" isDefault="1">
                 <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="116" />
               </Parameter>
-              <Parameter id="bZ0ZUETupkmxmUBAhWhfsw" name="Peclet number (large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CalcPecletNumber.PecletNumber_l" isDefault="1">
+              <Parameter id="3ttu834F-EOnvm5jT-ncqg" name="Peclet number (small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CalcPecletNumber.PecletNumber_s" isDefault="1">
                 <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="116" />
               </Parameter>
-              <Parameter id="Iwi4WFahy0mibneoedk4gQ" name="Partition coefficient (interstitial/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" isDefault="1">
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="70" />
+              <Parameter id="sitbBrR3dUm-ZeFnFgADCw" name="Radius ratio (solute/large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_gamma_l" isDefault="1">
+                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="116" />
               </Parameter>
-              <Parameter id="r_VIOH61_0KOcgkWtiMihQ" name="P (small endothelial pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial_s" isDefault="1" displayUnit="cm/min">
+              <Parameter id="5kPbefPoFEqTztCHOAqcqg" name="Radius ratio (solute/small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_gamma_s" isDefault="1">
                 <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="80" />
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="116" />
               </Parameter>
-              <Parameter id="SutjngGjMUqwI6o4hVlbiQ" name="P (plasma&lt;-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial" isDefault="1" displayUnit="cm/min">
+              <Parameter id="4gCZpDMt_U6hDjoKSYMMvQ" name="Reflection coefficient (large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_sigma_l" isDefault="1">
                 <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="77" />
+                <Info min="0" flag="58" seq="1" ref="0" bb="2" group="89" />
               </Parameter>
-              <Parameter id="GhMxqgUE7kSd6S5onj5QVQ" name="P (large endothelial pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial_l" isDefault="1" displayUnit="cm/min">
+              <Parameter id="7pwWHs9S0EeF-n0W3syicA" name="Reflection coefficient (small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_sigma_s" isDefault="1">
                 <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="79" />
+                <Info min="0" flag="58" seq="1" ref="0" bb="2" group="90" />
               </Parameter>
             </Children>
           </Container>
-          <Parameter id="Qhe2vq1E40iwGMEZJwZicg" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" isDefault="1" displayUnit="cm²">
+          <Parameter id="vt3alu0KjEa_iwRot9LaVQ" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" isDefault="1" displayUnit="cm²">
             <Tags>
               <Tag value="Neighborhood: Plasma / Interstitial" />
             </Tags>
@@ -16564,318 +16724,318 @@
           </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="p1BqkyuFqkSd0Dd9FaNO2Q" name="Brain_pls_Brain_end" mode="Logical" containerType="Neighborhood" firstNeighbor="nHn-DlMwp0-NSpksuD5rxQ" secondNeighbor="CC-B3cUCDk6CNAJ95txMFQ">
+      <NeighborhoodBuilder id="W9CdZMnMnkqhH_steqEDyQ" name="Brain_pls_VenousBlood_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="B3ppcgqIdE6xO8qFxNT7fw" secondNeighbor="JxP9aCWtgUGhXH_R7w1Z2Q">
         <Tags>
-          <Tag value="Neighborhood: Plasma / Endosome" />
+          <Tag value="Neighborhood: Plasma / Plasma" />
         </Tags>
         <Children>
-          <Container id="xNe864_mAEWmWALYEtG18Q" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="gf9d7I99Dkm6m5T7oz09ng" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="DmqlKnoO9UmxP1DXokx9aw" name="Brain_pls_Brain_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="nHn-DlMwp0-NSpksuD5rxQ" secondNeighbor="dv3uqCi9AUOvhi8Uvd3bjA">
+      <NeighborhoodBuilder id="XCnGJ7HClkmOtxaAYxNdVA" name="Fat_bc_VenousBlood_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="YYBXz19EnU6njErj_BuzIw" secondNeighbor="s69zFizy-UefsPiLLFllaw">
         <Tags>
-          <Tag value="Neighborhood: Plasma / BloodCells" />
+          <Tag value="Neighborhood: BloodCells / BloodCells" />
         </Tags>
         <Children>
-          <Container id="I5qJFzu-V0CnO40-xIwZnQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
-          <Parameter id="aL5kwEzYhUKupTPMyCIhKQ" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" isDefault="1" displayUnit="cm²">
-            <Tags>
-              <Tag value="Neighborhood: Plasma / BloodCells" />
-            </Tags>
-            <Info min="0" flag="122" seq="4" ref="0" bb="32" group="104" />
-          </Parameter>
+          <Container id="KcWzG2duX0a5OShUTz8wmw" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="rBjQPqMHOUC5nCX1wb84aQ" name="Brain_end_Brain_ecl" mode="Logical" containerType="Neighborhood" firstNeighbor="CC-B3cUCDk6CNAJ95txMFQ" secondNeighbor="eDJJFajIZ0qqc5SSL9V05w">
+      <NeighborhoodBuilder id="PjJMkJeDDEuHP1grM3MwCw" name="Fat_end_Fat_ecl" mode="Logical" containerType="Neighborhood" firstNeighbor="Lun94IwcFUWsH-RFL5jZNg" secondNeighbor="0MjJnhA0s063jmqn9J-j4Q">
         <Tags>
           <Tag value="Neighborhood: Endosome / EndosomalClearance" />
         </Tags>
         <Children>
-          <Container id="wNpFRRQKY0CTt8UJXYPn9Q" name="MoleculeProperties" mode="Logical" containerType="Other" />
-        </Children>
-      </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="x1RBapnA5k2ZrJyKvTAPpg" name="Brain_bc_VenousBlood_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="dv3uqCi9AUOvhi8Uvd3bjA" secondNeighbor="BvN_npw9ekupr6uHYGaj_g">
-        <Tags>
-          <Tag value="Neighborhood: BloodCells / BloodCells" />
-        </Tags>
-        <Children>
-          <Container id="XxntzNi1_06xgVBrVrUZxw" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="8Ekz3KdyS0OtV_C0MV_wfA" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="_5hYBl0r4UOIjFXIoTTGKw" name="Brain_pls_VenousBlood_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="nHn-DlMwp0-NSpksuD5rxQ" secondNeighbor="lg3JPjAHSUaKoE7vwc_rTw">
+      <NeighborhoodBuilder id="r8EvATlWG0C-omneHi87MQ" name="Fat_end_Fat_int" mode="Logical" containerType="Neighborhood" firstNeighbor="Lun94IwcFUWsH-RFL5jZNg" secondNeighbor="QLel30G7_0uDT_kJcNz-HA">
         <Tags>
-          <Tag value="Neighborhood: Plasma / Plasma" />
+          <Tag value="Neighborhood: Endosome / Interstitial" />
         </Tags>
         <Children>
-          <Container id="4_WHPD3LOEKjuzpYwhcfFg" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="WUd2xwyJokGn2arljM6mDw" name="MoleculeProperties" mode="Logical" containerType="Other" />
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+              <Parameter id="Xk3YPBrsmUSNc2xblgjMkg" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
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+              <Parameter id="q5aRK22FqEyAWnWKepk9RA" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
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+          <Parameter id="7cJph4-pq0ar3tZMzJTu0w" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_fat" isDefault="1" displayUnit="cm²">
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               <Tag value="Neighborhood: Interstitial / Intracellular" />
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+              <Tag value="Neighborhood: Plasma / BloodCells" />
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+      <NeighborhoodBuilder id="IOHKmEIdSkKcPHwBP1uJRg" name="Fat_pls_Fat_end" mode="Logical" containerType="Neighborhood" firstNeighbor="C5HmC00ryECjS1x2r0r1xw" secondNeighbor="Lun94IwcFUWsH-RFL5jZNg">
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+      <NeighborhoodBuilder id="58NaerpgIkubC9A09BdWxQ" name="Fat_pls_Fat_int" mode="Logical" containerType="Neighborhood" firstNeighbor="C5HmC00ryECjS1x2r0r1xw" secondNeighbor="QLel30G7_0uDT_kJcNz-HA">
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-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="69" />
+              <Parameter id="lXfzj4NQ1EmjRJSz_pUSPA" name="P (large endothelial pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial_l" isDefault="1" displayUnit="cm/min">
+                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
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+              <Parameter id="mf19fCXiCkWfcbDXuZGH8w" name="P (plasma&lt;-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial" isDefault="1" displayUnit="cm/min">
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-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+              <Parameter id="q7Au3hEdn0qsIQKW4_bYiw" name="P (small endothelial pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial_s" isDefault="1" displayUnit="cm/min">
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-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
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-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+              <Parameter id="zO8DbIlMyESp1Vgt7_8Rpg" name="Peclet number (large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CalcPecletNumber.PecletNumber_l" isDefault="1">
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-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
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-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="76" />
+              <Parameter id="4zAig_fdYEmCK7dxlBY1Vg" name="Radius ratio (solute/large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_gamma_l" isDefault="1">
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-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="78" />
+              <Parameter id="zWizFxAcgUOgAom0CydY1Q" name="Radius ratio (solute/small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_gamma_s" isDefault="1">
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+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="116" />
+              </Parameter>
+              <Parameter id="b12mCuo-3US2NYbBPwPSvQ" name="Reflection coefficient (large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_sigma_l" isDefault="1">
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+                <Info min="0" flag="58" seq="1" ref="0" bb="2" group="89" />
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+          <Parameter id="GY9YW8r8tkaspkmWEE_0BA" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" isDefault="1" displayUnit="cm²">
             <Tags>
-              <Tag value="Neighborhood: Interstitial / Intracellular" />
+              <Tag value="Neighborhood: Plasma / Interstitial" />
             </Tags>
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+      <NeighborhoodBuilder id="Aq-tsJylF0iH_R9AKcVI8g" name="Fat_pls_VenousBlood_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="C5HmC00ryECjS1x2r0r1xw" secondNeighbor="JxP9aCWtgUGhXH_R7w1Z2Q">
         <Tags>
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         </Tags>
         <Children>
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+          <Container id="7RikE2HV20qIWm-EqE1zdg" name="MoleculeProperties" mode="Logical" containerType="Other" />
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-              <Parameter id="GJINU1m-Cku34FSnlfUGAw" name="Partition coefficient (interstitial/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" isDefault="1">
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="70" />
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="116" />
               </Parameter>
-              <Parameter id="rok8untpUUyyQ7G3BQd5YQ" name="P (small endothelial pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial_s" isDefault="1" displayUnit="cm/min">
+              <Parameter id="PZfAOdZllU6Mw_PqROLnkA" name="Reflection coefficient (large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_sigma_l" isDefault="1">
                 <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="80" />
+                <Info min="0" flag="58" seq="1" ref="0" bb="2" group="89" />
               </Parameter>
-              <Parameter id="OWeLtwV340S4cwuuwfV8yg" name="Radius ratio (solute/large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_gamma_l" isDefault="1">
+              <Parameter id="2XhlALb8RkqUTgYZOkFHFw" name="Reflection coefficient (small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_sigma_s" isDefault="1">
                 <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="116" />
+                <Info min="0" flag="58" seq="1" ref="0" bb="2" group="90" />
               </Parameter>
             </Children>
           </Container>
-          <Parameter id="E1SX8t8IK0qxm1KIyjyMeg" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" isDefault="1" displayUnit="cm²">
+          <Parameter id="wGSXy7kfXEaZbMujrjOcsA" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" isDefault="1" displayUnit="cm²">
             <Tags>
               <Tag value="Neighborhood: Plasma / Interstitial" />
             </Tags>
@@ -16884,158 +17044,158 @@
           </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="GH_Z1GBsLUCxKqQjxZ0IjQ" name="Gonads_pls_Gonads_end" mode="Logical" containerType="Neighborhood" firstNeighbor="fp9hd7IFYU2_YcZqajTbVw" secondNeighbor="vqDhcGRzm0axJ3Ldu4Wumw">
+      <NeighborhoodBuilder id="m2716Dp5ME6k-NuSrP_xYg" name="Gonads_pls_VenousBlood_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="df0Tdp64lk2CyQa_SXJyIA" secondNeighbor="JxP9aCWtgUGhXH_R7w1Z2Q">
         <Tags>
-          <Tag value="Neighborhood: Plasma / Endosome" />
+          <Tag value="Neighborhood: Plasma / Plasma" />
         </Tags>
         <Children>
-          <Container id="pKvVGT9NY0OEhC6VHNqnIw" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="kyQYi5vBmE2gZKhjZXhzcA" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="vC77h50STE--EDTyrqix0Q" name="Gonads_pls_Gonads_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="fp9hd7IFYU2_YcZqajTbVw" secondNeighbor="yt-WJvndLE2axNwVZo-GoA">
+      <NeighborhoodBuilder id="VKC_2S6gHEKEanTwTf5pIg" name="Heart_bc_VenousBlood_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="5ipnQqMXH02UkoNY4MBfnQ" secondNeighbor="s69zFizy-UefsPiLLFllaw">
         <Tags>
-          <Tag value="Neighborhood: Plasma / BloodCells" />
+          <Tag value="Neighborhood: BloodCells / BloodCells" />
         </Tags>
         <Children>
-          <Container id="u22mRBq3Ak-vMp05vbgrYg" name="MoleculeProperties" mode="Logical" containerType="Other" />
-          <Parameter id="jO8krAS9U0yvuurm43BY2A" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" isDefault="1" displayUnit="cm²">
-            <Tags>
-              <Tag value="Neighborhood: Plasma / BloodCells" />
-            </Tags>
-            <Info min="0" flag="122" seq="6" ref="0" bb="32" group="104" />
-          </Parameter>
+          <Container id="BVS621rTSEi5jceAso441g" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="p-F_DL2IOUeyjMhkt3Nskg" name="Gonads_int_VenousBlood_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="Y730tvKo50Gb04_T3e9b9w" secondNeighbor="lg3JPjAHSUaKoE7vwc_rTw">
+      <NeighborhoodBuilder id="KgIJpvAm9EyWo_rIegsfSQ" name="Heart_end_Heart_ecl" mode="Logical" containerType="Neighborhood" firstNeighbor="P6pUnAGbakyDWoKiBVGz-w" secondNeighbor="0MjJnhA0s063jmqn9J-j4Q">
         <Tags>
-          <Tag value="Neighborhood: Interstitial / Plasma" />
+          <Tag value="Neighborhood: Endosome / EndosomalClearance" />
+        </Tags>
+        <Children>
+          <Container id="lPNaVMRSR0mVZar08CnYVQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="6IpRTmoUkUiK-de2nsq9lw" name="Heart_end_Heart_int" mode="Logical" containerType="Neighborhood" firstNeighbor="P6pUnAGbakyDWoKiBVGz-w" secondNeighbor="Kt7urTNg70iGdMh3YnkiFg">
+        <Tags>
+          <Tag value="Neighborhood: Endosome / Interstitial" />
         </Tags>
         <Children>
-          <Container id="W0qrNy9sQECt-Lrbtz0UzA" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="PPT2P65OqUWWPLolQnP3Qg" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="rvhS_XC7M0Sw_EY-NNn6vA" name="Gonads_int_Gonads_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="Y730tvKo50Gb04_T3e9b9w" secondNeighbor="gk1op0udfEeTZR-unExG_Q">
+      <NeighborhoodBuilder id="HnhuZSXC40KYKCWM3fCTRg" name="Heart_int_Heart_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="Kt7urTNg70iGdMh3YnkiFg" secondNeighbor="VPQ2UyYE3EyNuUMijR98yA">
         <Tags>
           <Tag value="Neighborhood: Interstitial / Intracellular" />
         </Tags>
         <Children>
-          <Container id="Z6IJRVNd10-cD-50oNCZxw" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="w1A6EQOcW0uQK2FpKcselQ" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="BOaudr5SF0WKoWfZTcUB0w" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+              <Parameter id="_WJiedgZzEe1Sjym6TLPDg" name="P (interstitial-&gt;intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" isDefault="1" displayUnit="cm/min">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="78" />
               </Parameter>
-              <Parameter id="5rY5skbbiE6PxTq6dYdehg" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="69" />
+              <Parameter id="VdxIH7mx4ku7Fj8IHA4uYA" name="P (intracellular-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" isDefault="1" displayUnit="cm/min">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="76" />
               </Parameter>
-              <Parameter id="qslV3bKhqU-fV2QwmbYKww" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
+              <Parameter id="uVzrhx1jh0yj3NMw9RNnSg" name="P*SA interstitial -&gt; intracellular" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" isDefault="1" displayUnit="l/min">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="uWiMDqwnpEma-IkET7nJKQ" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
+              <Parameter id="gsnztVUQ7ECcUlKsV2K55A" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="aHNIXvs_EUSUG5ZOR-qOag" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
+              <Parameter id="z6VNurqNSECPMzojHfjxfQ" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="8D_lkDESYki7ldj21a4-jg" name="P*SA interstitial -&gt; intracellular" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" isDefault="1" displayUnit="l/min">
+              <Parameter id="oyGF-0lCLESR_-bQSdFg4A" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="0C6CKUdfE0aWbbn56hyrBg" name="P (intracellular-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" isDefault="1" displayUnit="cm/min">
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="76" />
+              <Parameter id="m2i3OLgSPkKOQ_nhNXo1Pw" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="69" />
               </Parameter>
-              <Parameter id="OOCIvf--NUGfr7_Y0jx7_g" name="P (interstitial-&gt;intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" isDefault="1" displayUnit="cm/min">
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="78" />
+              <Parameter id="hNq-gpYKMkaQN_yxsfbvWQ" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
               </Parameter>
             </Children>
           </Container>
-          <Parameter id="3s7I0KUDjkGLqiow-2uRlw" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_tes" isDefault="1" displayUnit="cm²">
+          <Parameter id="XXFcugl29k2j9XBKbn_S6g" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_hrt" isDefault="1" displayUnit="cm²">
             <Tags>
               <Tag value="Neighborhood: Interstitial / Intracellular" />
             </Tags>
-            <Info min="0" flag="122" seq="4" ref="0" bb="32" group="105" />
+            <Info min="0" flag="122" seq="5" ref="0" bb="32" group="105" />
           </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="DwAafVJEok2xOGjAdCfzcQ" name="Gonads_end_Gonads_int" mode="Logical" containerType="Neighborhood" firstNeighbor="vqDhcGRzm0axJ3Ldu4Wumw" secondNeighbor="Y730tvKo50Gb04_T3e9b9w">
-        <Tags>
-          <Tag value="Neighborhood: Endosome / Interstitial" />
-        </Tags>
-        <Children>
-          <Container id="hg37GJY_yEWYlhEU31K-6w" name="MoleculeProperties" mode="Logical" containerType="Other" />
-        </Children>
-      </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="b3FMgNnmU06BzW34L4WQhw" name="Gonads_end_Gonads_ecl" mode="Logical" containerType="Neighborhood" firstNeighbor="vqDhcGRzm0axJ3Ldu4Wumw" secondNeighbor="eDJJFajIZ0qqc5SSL9V05w">
+      <NeighborhoodBuilder id="IBSCtYurxkOsUOhVnivSXA" name="Heart_int_VenousBlood_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="Kt7urTNg70iGdMh3YnkiFg" secondNeighbor="JxP9aCWtgUGhXH_R7w1Z2Q">
         <Tags>
-          <Tag value="Neighborhood: Endosome / EndosomalClearance" />
+          <Tag value="Neighborhood: Interstitial / Plasma" />
         </Tags>
         <Children>
-          <Container id="boFt0nA8lEWISJX1Gzr02g" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="whxXb9oEaU6o6glUW8gbLQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="lE0pahnD40ObcWuPvdRYqA" name="Gonads_bc_VenousBlood_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="yt-WJvndLE2axNwVZo-GoA" secondNeighbor="BvN_npw9ekupr6uHYGaj_g">
+      <NeighborhoodBuilder id="B_LW7aVXVUCfqHyvzhF08Q" name="Heart_pls_Heart_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="BPlJ6mgA6EK5m9A3L5pXww" secondNeighbor="5ipnQqMXH02UkoNY4MBfnQ">
         <Tags>
-          <Tag value="Neighborhood: BloodCells / BloodCells" />
+          <Tag value="Neighborhood: Plasma / BloodCells" />
         </Tags>
         <Children>
-          <Container id="80oxC4SMDU-tqR6u6BCC7g" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="nBmxux-cfUyTdpHL97o-Ig" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Parameter id="ipFFr5qwOEymRO21ADQIcA" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" isDefault="1" displayUnit="cm²">
+            <Tags>
+              <Tag value="Neighborhood: Plasma / BloodCells" />
+            </Tags>
+            <Info min="0" flag="122" seq="7" ref="0" bb="32" group="104" />
+          </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="uOI4kRXdfkeAyYizYutg6g" name="Heart_pls_VenousBlood_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="8_Mn7V4mf0aieii5LhKrpQ" secondNeighbor="lg3JPjAHSUaKoE7vwc_rTw">
+      <NeighborhoodBuilder id="I5vxkb-Kq0CFLCuOXqhAsw" name="Heart_pls_Heart_end" mode="Logical" containerType="Neighborhood" firstNeighbor="BPlJ6mgA6EK5m9A3L5pXww" secondNeighbor="P6pUnAGbakyDWoKiBVGz-w">
         <Tags>
-          <Tag value="Neighborhood: Plasma / Plasma" />
+          <Tag value="Neighborhood: Plasma / Endosome" />
         </Tags>
         <Children>
-          <Container id="SdzeYCnVr0SrUf3ilvjWEw" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="C-EF0lmZaE2kluKQkgmNIw" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="Hqp8VKR860adt2wJFtDYcg" name="Heart_pls_Heart_int" mode="Logical" containerType="Neighborhood" firstNeighbor="8_Mn7V4mf0aieii5LhKrpQ" secondNeighbor="OoxKpv391E2lXjcNBBrNYQ">
+      <NeighborhoodBuilder id="jaep758d4EatlDw0rTklog" name="Heart_pls_Heart_int" mode="Logical" containerType="Neighborhood" firstNeighbor="BPlJ6mgA6EK5m9A3L5pXww" secondNeighbor="Kt7urTNg70iGdMh3YnkiFg">
         <Tags>
           <Tag value="Neighborhood: Plasma / Interstitial" />
         </Tags>
         <Children>
-          <Container id="JqS3bIloOU2Aea5Jlj_M-g" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="v2_2lA2cAki_Ij8fW74TpQ" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="-wJv7XYK6UmVNzNVNUcEZw" name="Peclet number (large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CalcPecletNumber.PecletNumber_l" isDefault="1">
-                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="116" />
-              </Parameter>
-              <Parameter id="Kg10O02gzkGSU8w55vSFMQ" name="P (large endothelial pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial_l" isDefault="1" displayUnit="cm/min">
+              <Parameter id="wC4dN5_yl0qjcrK5tIV1kg" name="P (large endothelial pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial_l" isDefault="1" displayUnit="cm/min">
                 <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="79" />
               </Parameter>
-              <Parameter id="pHpVMUeDAkaibW8czy0A9g" name="P (plasma&lt;-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial" isDefault="1" displayUnit="cm/min">
+              <Parameter id="kvb_Dcfr-k-ksDw812x8-w" name="P (plasma&lt;-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial" isDefault="1" displayUnit="cm/min">
                 <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="77" />
               </Parameter>
-              <Parameter id="hMHLmvseGUOaZynXaxaGJQ" name="Partition coefficient (interstitial/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" isDefault="1">
+              <Parameter id="1U2pnw79qk6CZoUYyV5_bw" name="P (small endothelial pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial_s" isDefault="1" displayUnit="cm/min">
+                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="80" />
+              </Parameter>
+              <Parameter id="92O8iL7HSUaoWQLaOlbbPw" name="Partition coefficient (interstitial/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" isDefault="1">
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="70" />
               </Parameter>
-              <Parameter id="wbwxEMlWeEuwjSjOu7iCvA" name="Peclet number (small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CalcPecletNumber.PecletNumber_s" isDefault="1">
+              <Parameter id="ICgSmpBWPUutBI_SMPe66w" name="Peclet number (large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CalcPecletNumber.PecletNumber_l" isDefault="1">
                 <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="116" />
               </Parameter>
-              <Parameter id="yf2bY7N6D0SvpvFQv0hfZw" name="Radius ratio (solute/large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_gamma_l" isDefault="1">
+              <Parameter id="fhBsSUH7dkS03zkZZ903fw" name="Peclet number (small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CalcPecletNumber.PecletNumber_s" isDefault="1">
+                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="116" />
+              </Parameter>
+              <Parameter id="auS9zoxi7UOPVY1pMP0rGA" name="Radius ratio (solute/large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_gamma_l" isDefault="1">
                 <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                 <Info min="0" flag="52" seq="1" ref="0" bb="2" group="116" />
               </Parameter>
-              <Parameter id="FwmyNsqD8UCetr9ynIeTuQ" name="Radius ratio (solute/small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_gamma_s" isDefault="1">
+              <Parameter id="zMZTx83M7Um1GoCjRNxghg" name="Radius ratio (solute/small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_gamma_s" isDefault="1">
                 <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                 <Info min="0" flag="52" seq="1" ref="0" bb="2" group="116" />
               </Parameter>
-              <Parameter id="cT0ChzcsJk-MvuyhvFg61A" name="Reflection coefficient (large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_sigma_l" isDefault="1">
+              <Parameter id="mwAV2aIlUkaDNSJbeYx7yg" name="Reflection coefficient (large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_sigma_l" isDefault="1">
                 <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                 <Info min="0" flag="58" seq="1" ref="0" bb="2" group="89" />
               </Parameter>
-              <Parameter id="mxVVtzOZTUGAyoPrmEilzQ" name="Reflection coefficient (small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_sigma_s" isDefault="1">
+              <Parameter id="UFlIaJRUaEOJW2cNxqpYJg" name="Reflection coefficient (small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_sigma_s" isDefault="1">
                 <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                 <Info min="0" flag="58" seq="1" ref="0" bb="2" group="90" />
               </Parameter>
-              <Parameter id="n1hfX47TNkObiq8Rgk7epw" name="P (small endothelial pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial_s" isDefault="1" displayUnit="cm/min">
-                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="80" />
-              </Parameter>
             </Children>
           </Container>
-          <Parameter id="CnA_hbidhUOcjaf-vWPfiQ" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" isDefault="1" displayUnit="cm²">
+          <Parameter id="jKjLUHhRiEyGTOAGewBa-w" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" isDefault="1" displayUnit="cm²">
             <Tags>
               <Tag value="Neighborhood: Plasma / Interstitial" />
             </Tags>
@@ -17044,715 +17204,652 @@
           </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="h8q1kZAzEkGP-peKVHxWGA" name="Heart_bc_VenousBlood_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="RYYFApvGe0abhj2vYXsp6A" secondNeighbor="BvN_npw9ekupr6uHYGaj_g">
+      <NeighborhoodBuilder id="c9NkAH2uwUipBGj-Xnb2oQ" name="Heart_pls_VenousBlood_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="BPlJ6mgA6EK5m9A3L5pXww" secondNeighbor="JxP9aCWtgUGhXH_R7w1Z2Q">
         <Tags>
-          <Tag value="Neighborhood: BloodCells / BloodCells" />
+          <Tag value="Neighborhood: Plasma / Plasma" />
         </Tags>
         <Children>
-          <Container id="OIU5So_r1U6gHe6o95sEdw" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="FeNRtkBLSU--qq_hG8gtAQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="jL8OzuYcoEW0mKa7Tp13Dg" name="Heart_end_Heart_ecl" mode="Logical" containerType="Neighborhood" firstNeighbor="I3jADwRC9Emy2AlRkskKwA" secondNeighbor="eDJJFajIZ0qqc5SSL9V05w">
+      <NeighborhoodBuilder id="qFHWne4P0US8luIOHuKnnQ" name="Kidney_bc_VenousBlood_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="U7McxF7HlEmM8C7PIYjgWQ" secondNeighbor="s69zFizy-UefsPiLLFllaw">
         <Tags>
-          <Tag value="Neighborhood: Endosome / EndosomalClearance" />
+          <Tag value="Neighborhood: BloodCells / BloodCells" />
         </Tags>
         <Children>
-          <Container id="W92HXlV1L0GaCFtwkHLu0g" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="AB2zjtKLTEiUX8rN4h265g" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="ZgBbhu13kUKrjZd9h3jfxg" name="Heart_end_Heart_int" mode="Logical" containerType="Neighborhood" firstNeighbor="I3jADwRC9Emy2AlRkskKwA" secondNeighbor="OoxKpv391E2lXjcNBBrNYQ">
+      <NeighborhoodBuilder id="FR_9NvxnxkGGEUbQhN0HRg" name="Kidney_end_Kidney_ecl" mode="Logical" containerType="Neighborhood" firstNeighbor="8SQBGfUVrUmCoTI4sUk5wg" secondNeighbor="0MjJnhA0s063jmqn9J-j4Q">
         <Tags>
-          <Tag value="Neighborhood: Endosome / Interstitial" />
+          <Tag value="Neighborhood: Endosome / EndosomalClearance" />
         </Tags>
         <Children>
-          <Container id="fp3XYrQIHEK8JQnNms2bGQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="v7ZEhRlvvEyCDIG9Ar-dxw" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="4wVlAx8yJU-fkKgOZRlNdQ" name="Heart_pls_Heart_end" mode="Logical" containerType="Neighborhood" firstNeighbor="8_Mn7V4mf0aieii5LhKrpQ" secondNeighbor="I3jADwRC9Emy2AlRkskKwA">
+      <NeighborhoodBuilder id="oyMRkmIiWE6r8PC4NNE8TA" name="Kidney_end_Kidney_int" mode="Logical" containerType="Neighborhood" firstNeighbor="8SQBGfUVrUmCoTI4sUk5wg" secondNeighbor="9ncaV9nIy06ezsXRF6i9vA">
         <Tags>
-          <Tag value="Neighborhood: Plasma / Endosome" />
+          <Tag value="Neighborhood: Endosome / Interstitial" />
         </Tags>
         <Children>
-          <Container id="NsXzT2aYrUK5PzVBbMpB9g" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="EB6XDSI_REOENWD7APtweQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="Hn4YJh9irkSnam20CxICww" name="Heart_int_Heart_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="OoxKpv391E2lXjcNBBrNYQ" secondNeighbor="pekjg5mryUqPj4L64tjtgA">
+      <NeighborhoodBuilder id="R0QWHzY8xk2i4avPFAGEQw" name="Kidney_int_Kidney_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="9ncaV9nIy06ezsXRF6i9vA" secondNeighbor="_hb5yhppqky4cFZVOIOvuQ">
         <Tags>
           <Tag value="Neighborhood: Interstitial / Intracellular" />
         </Tags>
         <Children>
-          <Container id="Jz6wqAYzXk6ApV3DNQrkgg" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="bLnq0ibrNU-GMrMuArFRyw" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="5JHiWLU9JkSCAU3_FMcwjA" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
+              <Parameter id="xP75itCJ50qOBseH8S63Tw" name="P (interstitial-&gt;intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" isDefault="1" displayUnit="cm/min">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="78" />
+              </Parameter>
+              <Parameter id="Xmsr6sx4HkKGuPbhBG5GJA" name="P (intracellular-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" isDefault="1" displayUnit="cm/min">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="76" />
+              </Parameter>
+              <Parameter id="svyj5hNws0mqIcAmB6gEqw" name="P*SA interstitial -&gt; intracellular" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" isDefault="1" displayUnit="l/min">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="KQtobNIZT02FVbhCwDBwiQ" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="KbBXIBEOHUKkyFqGg09I1w" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
+              <Parameter id="pTYrpZJGPEy5BSCrRZs8yg" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="lruCznvQikK04XHtdP-GqQ" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
+              <Parameter id="llQLWzlMRUGLI4_Tl4PSXQ" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="QyJcf2zUTkiwxfRNUqGLQg" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
+              <Parameter id="20lXwVRtX0aR82I8p_P4Vg" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="69" />
               </Parameter>
-              <Parameter id="VCHQZzACBE--crjycPJElQ" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
+              <Parameter id="DADur_4prE-AClNs0rpuiQ" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
               </Parameter>
-              <Parameter id="pnZIlbFDVUyM3DGpFO-fuA" name="P (interstitial-&gt;intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" isDefault="1" displayUnit="cm/min">
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="78" />
-              </Parameter>
-              <Parameter id="zGoFKnBUG0uFS5pfgafdQg" name="P (intracellular-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" isDefault="1" displayUnit="cm/min">
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="76" />
-              </Parameter>
-              <Parameter id="C3mqQ7fPm0OBXbUzflpDYQ" name="P*SA interstitial -&gt; intracellular" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" isDefault="1" displayUnit="l/min">
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
-              </Parameter>
             </Children>
           </Container>
-          <Parameter id="bwr_BInpvEWGEulWSqK1EQ" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_hrt" isDefault="1" displayUnit="cm²">
+          <Parameter id="8K59hmaVAEWTdIRNbWDZow" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_kid" isDefault="1" displayUnit="cm²">
             <Tags>
               <Tag value="Neighborhood: Interstitial / Intracellular" />
             </Tags>
-            <Info min="0" flag="122" seq="5" ref="0" bb="32" group="105" />
+            <Info min="0" flag="122" seq="6" ref="0" bb="32" group="105" />
           </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="bg4s3RBaJkOfK_TcM3ih6w" name="Heart_pls_Heart_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="8_Mn7V4mf0aieii5LhKrpQ" secondNeighbor="RYYFApvGe0abhj2vYXsp6A">
+      <NeighborhoodBuilder id="3rTLjPdk9Ui-IC3wZ4QJLg" name="Kidney_int_VenousBlood_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="9ncaV9nIy06ezsXRF6i9vA" secondNeighbor="JxP9aCWtgUGhXH_R7w1Z2Q">
         <Tags>
-          <Tag value="Neighborhood: Plasma / BloodCells" />
+          <Tag value="Neighborhood: Interstitial / Plasma" />
         </Tags>
         <Children>
-          <Container id="ZYQC1H5lX0yrLl0Gg_i-cQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
-          <Parameter id="38odqdL8Dkqpr_NTwt0yyg" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" isDefault="1" displayUnit="cm²">
-            <Tags>
-              <Tag value="Neighborhood: Plasma / BloodCells" />
-            </Tags>
-            <Info min="0" flag="122" seq="7" ref="0" bb="32" group="104" />
-          </Parameter>
+          <Container id="jdfDkHxuTEilpPpzeCWb4g" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="0e5JBKBrkUCXQnm580fsvw" name="Heart_int_VenousBlood_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="OoxKpv391E2lXjcNBBrNYQ" secondNeighbor="lg3JPjAHSUaKoE7vwc_rTw">
+      <NeighborhoodBuilder id="gNQxX_PDO0Gf-WOFRW0SsA" name="Kidney_cell_Kidney_ur" mode="Logical" containerType="Neighborhood" firstNeighbor="_hb5yhppqky4cFZVOIOvuQ" secondNeighbor="2DuthfP6lEGKgEghG9cNbg">
         <Tags>
-          <Tag value="Neighborhood: Interstitial / Plasma" />
+          <Tag value="Neighborhood: Intracellular / Urine" />
         </Tags>
         <Children>
-          <Container id="LIa01X8UAEyAMuOjVlGNMQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="mAovpGe6hEKNW0cC2ddEkg" name="MoleculeProperties" mode="Logical" containerType="Other">
+            <Children>
+              <Parameter id="ujeh4AAlDE-ZC-5YbcXbPw" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_water_cell_Kidney" isDefault="1">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+              </Parameter>
+            </Children>
+          </Container>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="IStfC3JHOUihV7FlAYo_VQ" name="Kidney_bc_VenousBlood_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="rqTamjfWr0Otkg8ihwHbnA" secondNeighbor="BvN_npw9ekupr6uHYGaj_g">
+      <NeighborhoodBuilder id="1CbM1gVU-ESTWZ9QgFoS2Q" name="Kidney_pls_Kidney_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="AErFqOgHOE2YxQBOP5vPBA" secondNeighbor="U7McxF7HlEmM8C7PIYjgWQ">
         <Tags>
-          <Tag value="Neighborhood: BloodCells / BloodCells" />
+          <Tag value="Neighborhood: Plasma / BloodCells" />
         </Tags>
         <Children>
-          <Container id="vusM7ouxtkCuYV_tJihbtw" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="AnjZxnWTaEC8sRrETR_ZtQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Parameter id="GDu4RMJLO0yLsG4p_nU9LQ" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" isDefault="1" displayUnit="cm²">
+            <Tags>
+              <Tag value="Neighborhood: Plasma / BloodCells" />
+            </Tags>
+            <Info min="0" flag="122" seq="8" ref="0" bb="32" group="104" />
+          </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="0YIByxg_wkePGnfR5Z1gXw" name="Kidney_end_Kidney_ecl" mode="Logical" containerType="Neighborhood" firstNeighbor="GiTWw6Wj0E6m5Pz8xqfYrw" secondNeighbor="eDJJFajIZ0qqc5SSL9V05w">
+      <NeighborhoodBuilder id="Hd1-TrMuB06tdezPQS-K0A" name="Kidney_pls_Kidney_end" mode="Logical" containerType="Neighborhood" firstNeighbor="AErFqOgHOE2YxQBOP5vPBA" secondNeighbor="8SQBGfUVrUmCoTI4sUk5wg">
         <Tags>
-          <Tag value="Neighborhood: Endosome / EndosomalClearance" />
+          <Tag value="Neighborhood: Plasma / Endosome" />
         </Tags>
         <Children>
-          <Container id="lV-nzCJpUk2D-4MVp-e2Aw" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="BvtREUYREU-4KsxwEpD3jg" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="DjiRW76AkUC3Ah_QnhgnAg" name="UpperJejunum_pls_PortalVein_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="zYEnYXJwDk-OaWIn0YDDnA" secondNeighbor="5TpyW0Sd9USQGXc2frzUgA">
+      <NeighborhoodBuilder id="rzevZj5SmECzl8U2yHWhkA" name="Kidney_pls_Kidney_int" mode="Logical" containerType="Neighborhood" firstNeighbor="AErFqOgHOE2YxQBOP5vPBA" secondNeighbor="9ncaV9nIy06ezsXRF6i9vA">
         <Tags>
-          <Tag value="Neighborhood: Plasma / Plasma" />
+          <Tag value="Neighborhood: Plasma / Interstitial" />
         </Tags>
         <Children>
-          <Container id="_s4eZg_KJk26GnPo56DG6A" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="ma1J8b94hkaTrFdtRoiO6A" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="SjgIJc05q0e4VqdIu6BiZg" name="Mass transfer rate (mucosa to portal vein plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_forTwoPores.PARAM_MassTransferMucosaToPvePlasma" isDefault="1" displayUnit="µmol/min">
+              <Parameter id="4jQ7j6i_j0KXUFL7yl8v6g" name="P (large endothelial pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial_l" isDefault="1" displayUnit="cm/min">
                 <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="79" />
               </Parameter>
-            </Children>
-          </Container>
-        </Children>
-      </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="cxnbcBSIq0KR3mEqJY0N-g" name="Lumen_uje_UpperJejunum_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="z54PqeD3mkafETZ2sl_c1A" secondNeighbor="Gl4u9SB4D0S0tsiS1WYoSw">
-        <Tags>
-          <Tag value="Neighborhood: UpperJejunum / Intracellular" />
+              <Parameter id="IKCwhELtv0mvfU-nMSlgSw" name="P (plasma&lt;-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial" isDefault="1" displayUnit="cm/min">
+                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="77" />
+              </Parameter>
+              <Parameter id="Mo_BwvyHUE2zbHOI0CqDdA" name="P (small endothelial pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial_s" isDefault="1" displayUnit="cm/min">
+                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="80" />
+              </Parameter>
+              <Parameter id="HCO3SKFUc0qm-vrClJk0JA" name="Partition coefficient (interstitial/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" isDefault="1">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="70" />
+              </Parameter>
+              <Parameter id="6rOI_rTSCEqGhJHycPbVsQ" name="Peclet number (large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CalcPecletNumber.PecletNumber_l" isDefault="1">
+                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="116" />
+              </Parameter>
+              <Parameter id="2Olh6MVhY0ygmHyUf8A6kA" name="Peclet number (small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CalcPecletNumber.PecletNumber_s" isDefault="1">
+                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="116" />
+              </Parameter>
+              <Parameter id="crKJ74Mui0e8QtCuQx2DGw" name="Radius ratio (solute/large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_gamma_l" isDefault="1">
+                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="116" />
+              </Parameter>
+              <Parameter id="KPB_6cHts0u0LEphK2CxpQ" name="Radius ratio (solute/small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_gamma_s" isDefault="1">
+                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="116" />
+              </Parameter>
+              <Parameter id="s6Jqkmj1UEqq5sijk9OmEQ" name="Reflection coefficient (large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_sigma_l" isDefault="1">
+                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                <Info min="0" flag="58" seq="1" ref="0" bb="2" group="89" />
+              </Parameter>
+              <Parameter id="e_dfL6nrI0uR6_oVxFzykQ" name="Reflection coefficient (small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_sigma_s" isDefault="1">
+                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                <Info min="0" flag="58" seq="1" ref="0" bb="2" group="90" />
+              </Parameter>
+            </Children>
+          </Container>
+          <Parameter id="jEaK4EKFuEewLDZ26GpU0g" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" isDefault="1" displayUnit="cm²">
+            <Tags>
+              <Tag value="Neighborhood: Plasma / Interstitial" />
+            </Tags>
+            <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+            <Info min="0" flag="122" seq="6" ref="0" bb="32" group="106" />
+          </Parameter>
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="qN6IQUkseUyJ5BSfl0q7Mw" name="Kidney_pls_Kidney_ur" mode="Logical" containerType="Neighborhood" firstNeighbor="AErFqOgHOE2YxQBOP5vPBA" secondNeighbor="2DuthfP6lEGKgEghG9cNbg">
+        <Tags>
+          <Tag value="Neighborhood: Plasma / Urine" />
+        </Tags>
+        <Children>
+          <Container id="rxDsWBhZtEeoRXS3WUvPrA" name="MoleculeProperties" mode="Logical" containerType="Other" />
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="esSjS2e-BE6qPLCfbvteVQ" name="Kidney_pls_VenousBlood_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="AErFqOgHOE2YxQBOP5vPBA" secondNeighbor="JxP9aCWtgUGhXH_R7w1Z2Q">
+        <Tags>
+          <Tag value="Neighborhood: Plasma / Plasma" />
+        </Tags>
+        <Children>
+          <Container id="q2_iR09-mkOLryFemzhuoA" name="MoleculeProperties" mode="Logical" containerType="Other" />
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="cL_Wm31Ay02lYKclLO3GJQ" name="Lumen_uje_UpperJejunum_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="LPz6GLczUEWKm6sHP_khAQ" secondNeighbor="HD4pskxza0qRnIR9Xit2aA">
+        <Tags>
+          <Tag value="Neighborhood: UpperJejunum / Plasma" />
         </Tags>
         <Children>
-          <Container id="vAi0G3jgpUeo7bdcDzHT9g" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="hR9WC1pGs028HyJ5ecE3vQ" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="NtbtZQbFhECRy1bRyDFbAA" name="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" isDefault="1" displayUnit="µmol/min">
-                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+              <Parameter id="qNCisGIXQ0itOa9jVuR3Yw" name="Drug absorption rate (lumen to mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_DrugAbsorption_para" isDefault="1" displayUnit="µmol/min">
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
               </Parameter>
-              <Parameter id="S4kJArvwwE2kHpNKxIZynA" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K8" isDefault="1">
-                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              <Parameter id="F3TyenEKTUub44aNxdCMjA" name="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" isDefault="1" displayUnit="µmol/min">
+                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
               </Parameter>
-              <Parameter id="XKMObiHQtkmhXFRaMJfG8w" name="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" isDefault="1" displayUnit="µmol/min">
+              <Parameter id="rFbOsO0nqkyhmvE1EvMwPQ" name="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" isDefault="1" displayUnit="µmol/min">
                 <Info flag="52" seq="1" ref="0" bb="2" group="117" />
               </Parameter>
-              <Parameter id="4ndgf0Pz2UOkXb4mGRphYw" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F2" isDefault="1">
-                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+            </Children>
+          </Container>
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="64u1XEqTqEOQy4x3hV7U8g" name="Lumen_uje_UpperJejunum_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="LPz6GLczUEWKm6sHP_khAQ" secondNeighbor="f9JNWIahuU-I4czMeCoORQ">
+        <Tags>
+          <Tag value="Neighborhood: UpperJejunum / Intracellular" />
+        </Tags>
+        <Children>
+          <Container id="GYh5RpwXc0e6uosvTONlLA" name="MoleculeProperties" mode="Logical" containerType="Other">
+            <Children>
+              <Parameter id="AX7kPtMHE0ulOCABuYKmRQ" name="Drug absorption rate (lumen to mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_DrugAbsorption_trans" isDefault="1" displayUnit="µmol/min">
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
               </Parameter>
-              <Parameter id="zfWrtZemyUO-lqtIpsu3rA" name="pKa_pH_WS_cell_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F3" isDefault="1">
+              <Parameter id="4-ZBj4xe40CTGebQTbqzhA" name="P_int_trans_cell_lum_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_cell_lum_factor" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="NHMlbwHhg0OrRDmOiGlsbA" name="pKa_pH_WS_cell_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K1" isDefault="1">
+              <Parameter id="Jpdy5nchUUW3CN-0FHJTBw" name="P_int_trans_lum_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_lum_cell_factor" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="KZ9XTOK-1kyfPJ39e2Mq4w" name="pKa_pH_WS_cell_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K2" isDefault="1">
-                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              <Parameter id="1trZPYVOZU-zfD1GUQIdxA" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_K_cell_pls_UpperJejunum" isDefault="1">
+                <Info min="0" flag="36" seq="1" ref="0" bb="2" group="67" />
               </Parameter>
-              <Parameter id="b7rLHcCWH0CSjV_yr1WAuA" name="pKa_pH_WS_cell_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K3" isDefault="1">
-                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              <Parameter id="MhIld5ricUKDxR6FAlpnJQ" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_UpperJejunum" isDefault="1">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
               </Parameter>
-              <Parameter id="hbGMV4RiQU6Mongfz2nqMw" name="pKa_pH_WS_cell_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K4" isDefault="1">
+              <Parameter id="-gpctGMsLEmvx4UgPSnb5w" name="pKa_pH_WS_cell_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F1" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="P3Dgv9hBD0yq2wVLr5ydZQ" name="pKa_pH_WS_cell_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K5" isDefault="1">
+              <Parameter id="YRgQKKrk606Oc6fQHXAGrA" name="pKa_pH_WS_cell_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F2" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="WamueEas4EW6jWjV0PxVFA" name="pKa_pH_WS_cell_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K6" isDefault="1">
+              <Parameter id="pmNGJGR0ZkGHnbBvC3gT0A" name="pKa_pH_WS_cell_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F3" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
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+              <Parameter id="mwEHSqmKY0KjVfT6ipfZxg" name="pKa_pH_WS_cell_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K1" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
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+              <Parameter id="cAD_f9IQ5kmDyGDQ413NWg" name="pKa_pH_WS_cell_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K2" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="cal3fzXzNk22jZSd6Stl4g" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_UpperJejunum" isDefault="1">
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+              <Parameter id="V9ux9QyllE6lIUisagRRZg" name="pKa_pH_WS_cell_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K3" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="IbQJg1bJZ02pAjrBRgu76g" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F3" isDefault="1">
+              <Parameter id="gjtnJy5WkkiQYCQ4ERqg4w" name="pKa_pH_WS_cell_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K4" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
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+              <Parameter id="MyyyPpU_dE6U0t4J7MHdDA" name="pKa_pH_WS_cell_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K5" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
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+              <Parameter id="Oc0AKvof-0-qLEAgcCdsfA" name="pKa_pH_WS_cell_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K6" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
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+              <Parameter id="pYu3ghlqS02lytQtPCBnWQ" name="pKa_pH_WS_cell_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K7" isDefault="1">
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               </Parameter>
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+              <Parameter id="fhzVnH1ZYkCVgrWsoZcGHA" name="pKa_pH_WS_cell_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K8" isDefault="1">
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+              <Parameter id="O7yIKH-QbUm5_gGyF3WNyg" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K3" isDefault="1">
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+              <Parameter id="CVR4O6KlDE2cVsNaW1G2Zw" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K4" isDefault="1">
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+              <Parameter id="6O1nVNAU-Eil1oWs-NVKyA" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K6" isDefault="1">
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-                <Info min="0" flag="36" seq="1" ref="0" bb="2" group="67" />
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-                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+              <Parameter id="--0Sa1kWskqoqQ0vIylPXw" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K8" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
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+              <Parameter id="SsPxt2i8mUGTOsaqHGC1ow" name="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" isDefault="1" displayUnit="µmol/min">
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+              <Parameter id="FMWpLnQz60eBPOUBDGyOew" name="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" isDefault="1" displayUnit="µmol/min">
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-      <NeighborhoodBuilder id="kOnVTk4EcEiH6-PN6GSsPw" name="UpperJejunum_bc_PortalVein_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="61L89GjSDka6dFRsLf5z4Q" secondNeighbor="oz2_zRPfzk-ZhQqUyIQ6kg">
+      <NeighborhoodBuilder id="EFVJQcHLVkW7m20oMdKlPw" name="UpperJejunum_pls_PortalVein_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="HD4pskxza0qRnIR9Xit2aA" secondNeighbor="d626iVqs-ESin5Db2bAqWg">
         <Tags>
-          <Tag value="Neighborhood: BloodCells / BloodCells" />
+          <Tag value="Neighborhood: Plasma / Plasma" />
         </Tags>
         <Children>
-          <Container id="u5uQTMeMt0uRDgWmdn5rnQ" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="2fOol0NeR0a_Xhg-5rLy3A" name="MoleculeProperties" mode="Logical" containerType="Other">
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-              <Parameter id="lc7B7ul5ykSacNHkiCXm0A" name="Mass transfer rate (mucosa to portal vein blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_forTwoPores.PARAM_MassTransferMucosaToPveBloodCells" isDefault="1" displayUnit="µmol/min">
-                <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+              <Parameter id="bFmFbgRomUOmlyW6fxirMw" name="Mass transfer rate (mucosa to portal vein plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_forTwoPores.PARAM_MassTransferMucosaToPvePlasma" isDefault="1" displayUnit="µmol/min">
+                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
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+      <NeighborhoodBuilder id="P5kz3F95b02o7GYPh843rg" name="UpperJejunum_bc_PortalVein_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="43ryQ7QICUyzCzsGc7Evpg" secondNeighbor="J7qhrNHWA0i3ePh_JHm2LQ">
         <Tags>
-          <Tag value="Neighborhood: Intracellular / Urine" />
+          <Tag value="Neighborhood: BloodCells / BloodCells" />
         </Tags>
         <Children>
-          <Container id="0gVRmLLCDUyGxwFPS-ySug" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="wAOA253FtkOgFZHsumF01w" name="MoleculeProperties" mode="Logical" containerType="Other">
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-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+              <Parameter id="av3xGlAeC0SqI8n9SditjA" name="Mass transfer rate (mucosa to portal vein blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_forTwoPores.PARAM_MassTransferMucosaToPveBloodCells" isDefault="1" displayUnit="µmol/min">
+                <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
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-      <NeighborhoodBuilder id="FJh9MQOROkuy0yNI9l6s_Q" name="Kidney_pls_Kidney_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="uvY_1LLgFkmC19hgQgPOrA" secondNeighbor="rqTamjfWr0Otkg8ihwHbnA">
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-          <Parameter id="LBrlnWuLA0u381YecPJEmw" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" isDefault="1" displayUnit="cm²">
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-              <Tag value="Neighborhood: Plasma / BloodCells" />
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+      <NeighborhoodBuilder id="vUyznSr1RkK8JOVaATcxfg" name="Lumen_lje_LowerJejunum_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="Ngf59qCHkEOYMMJTcfumlw" secondNeighbor="9M_w50lqQkq4lTBvJwwuig">
         <Tags>
-          <Tag value="Neighborhood: Plasma / Interstitial" />
+          <Tag value="Neighborhood: LowerJejunum / Plasma" />
         </Tags>
         <Children>
-          <Container id="GqHDZ-PwAE-YxIL_z8_ejQ" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="_YFTU8qSd0CTxiZpJXDpFA" name="MoleculeProperties" mode="Logical" containerType="Other">
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-                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="116" />
-              </Parameter>
-              <Parameter id="tW5XDsIwxEWmYtCBe-e0LQ" name="P (large endothelial pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial_l" isDefault="1" displayUnit="cm/min">
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-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="79" />
-              </Parameter>
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-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="77" />
-              </Parameter>
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-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="80" />
-              </Parameter>
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-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="70" />
-              </Parameter>
-              <Parameter id="NMwfZA9Ph0ea15lOMq1Icg" name="Peclet number (small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CalcPecletNumber.PecletNumber_s" isDefault="1">
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-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="116" />
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-                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="116" />
-              </Parameter>
-              <Parameter id="iacq5sPryk6PQhi1aZeoZA" name="Reflection coefficient (large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_sigma_l" isDefault="1">
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-                <Info min="0" flag="58" seq="1" ref="0" bb="2" group="89" />
+              <Parameter id="etKwsNLJj0mmjXWMjXyhpg" name="Drug absorption rate (lumen to mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_DrugAbsorption_para" isDefault="1" displayUnit="µmol/min">
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
               </Parameter>
-              <Parameter id="VKY8VuGzTEG1ANK1DX1DMA" name="Reflection coefficient (small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_sigma_s" isDefault="1">
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-                <Info min="0" flag="58" seq="1" ref="0" bb="2" group="90" />
+              <Parameter id="lzk1EH2ObU6N8LYGRtCn-Q" name="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" isDefault="1" displayUnit="µmol/min">
+                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
               </Parameter>
-              <Parameter id="zzdu5mqS1UK-85kreGjWoQ" name="Peclet number (large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CalcPecletNumber.PecletNumber_l" isDefault="1">
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-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="116" />
+              <Parameter id="fNildlKCzUenC094aaQQkA" name="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" isDefault="1" displayUnit="µmol/min">
+                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
               </Parameter>
             </Children>
           </Container>
-          <Parameter id="Jghz6TUZLUuYSzUPTksz-A" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" isDefault="1" displayUnit="cm²">
-            <Tags>
-              <Tag value="Neighborhood: Plasma / Interstitial" />
-            </Tags>
-            <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-            <Info min="0" flag="122" seq="6" ref="0" bb="32" group="106" />
-          </Parameter>
-        </Children>
-      </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="yhWMi1apL0CpY1wQLSJ6nA" name="Kidney_pls_Kidney_ur" mode="Logical" containerType="Neighborhood" firstNeighbor="uvY_1LLgFkmC19hgQgPOrA" secondNeighbor="GvcFxEd_h0ygDCq9R9_NvQ">
-        <Tags>
-          <Tag value="Neighborhood: Plasma / Urine" />
-        </Tags>
-        <Children>
-          <Container id="S-FwQ7gHAEyg8qb71gIQXA" name="MoleculeProperties" mode="Logical" containerType="Other" />
-        </Children>
-      </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="bRmxKKTXxUKtWHDsXKL-3g" name="Kidney_pls_VenousBlood_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="uvY_1LLgFkmC19hgQgPOrA" secondNeighbor="lg3JPjAHSUaKoE7vwc_rTw">
-        <Tags>
-          <Tag value="Neighborhood: Plasma / Plasma" />
-        </Tags>
-        <Children>
-          <Container id="ZXybhluP2kSy2IRc-HpYMw" name="MoleculeProperties" mode="Logical" containerType="Other" />
-        </Children>
-      </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="E5celmpWPUmnmh5IiwZaBg" name="Kidney_pls_Kidney_end" mode="Logical" containerType="Neighborhood" firstNeighbor="uvY_1LLgFkmC19hgQgPOrA" secondNeighbor="GiTWw6Wj0E6m5Pz8xqfYrw">
-        <Tags>
-          <Tag value="Neighborhood: Plasma / Endosome" />
-        </Tags>
-        <Children>
-          <Container id="3ilQGm3R-U2BAMpXEZ-U5Q" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="HyjhlXxbOkWjxON9JZ4GcA" name="Kidney_int_VenousBlood_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="jJSesz8pl0OxjUISy7W-Sw" secondNeighbor="lg3JPjAHSUaKoE7vwc_rTw">
+      <NeighborhoodBuilder id="AKMzUxxNSEq8xv-b8AVpgw" name="Lumen_lje_LowerJejunum_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="Ngf59qCHkEOYMMJTcfumlw" secondNeighbor="vbzZRD1fTUGB9xYY7QdQcA">
         <Tags>
-          <Tag value="Neighborhood: Interstitial / Plasma" />
-        </Tags>
-        <Children>
-          <Container id="dfU0vGOaukCadStK01KorQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
-        </Children>
-      </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="HS5RDUaEpUukd1Lp4cE5RQ" name="Kidney_int_Kidney_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="jJSesz8pl0OxjUISy7W-Sw" secondNeighbor="y78VCOpnfEmYcNRW5tU4GQ">
-        <Tags>
-          <Tag value="Neighborhood: Interstitial / Intracellular" />
+          <Tag value="Neighborhood: LowerJejunum / Intracellular" />
         </Tags>
         <Children>
-          <Container id="w61X-wDaeEOHew6dfZIlpA" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="CTJQSfJhvkWK3qh0GLysOQ" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="1gNCh28NPkqef6sM50d6LQ" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
-              </Parameter>
-              <Parameter id="Qyp0eEOhdkK_WuGCsKm4Ug" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
-              </Parameter>
-              <Parameter id="bshvCNqzG0itdGQBffJ0Cg" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
-              </Parameter>
-              <Parameter id="v5Ehjk8Vwk-t3XCkfUkjbw" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="69" />
-              </Parameter>
-              <Parameter id="IaunPj1vUUSEJIw1dHraZw" name="P (interstitial-&gt;intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" isDefault="1" displayUnit="cm/min">
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="78" />
+              <Parameter id="XfUGOyj3e0eXIilIAF6-Bg" name="Drug absorption rate (lumen to mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_DrugAbsorption_trans" isDefault="1" displayUnit="µmol/min">
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
               </Parameter>
-              <Parameter id="YgHxV0PE4EqS0d-cYt6ACQ" name="P (intracellular-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" isDefault="1" displayUnit="cm/min">
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="76" />
+              <Parameter id="Tol_dDRjt0Wbqv4J0jaGbw" name="P_int_trans_cell_lum_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_cell_lum_factor" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="RUXI113rgU-4sbwWIyfrfg" name="P*SA interstitial -&gt; intracellular" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" isDefault="1" displayUnit="l/min">
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+              <Parameter id="NPFgGG159UOfPv3gqVoZoQ" name="P_int_trans_lum_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_lum_cell_factor" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="fEaq2q0WikKszT0DcCiVsw" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+              <Parameter id="zN852d_Slku2TzKgRZrBQw" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_K_cell_pls_LowerJejunum" isDefault="1">
+                <Info min="0" flag="36" seq="1" ref="0" bb="2" group="67" />
               </Parameter>
-            </Children>
-          </Container>
-          <Parameter id="yzPe7SR-WUmbKQ7C-py24A" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_kid" isDefault="1" displayUnit="cm²">
-            <Tags>
-              <Tag value="Neighborhood: Interstitial / Intracellular" />
-            </Tags>
-            <Info min="0" flag="122" seq="6" ref="0" bb="32" group="105" />
-          </Parameter>
-        </Children>
-      </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="ouQaPQjc-EOkwvwOQKFdoA" name="Lumen_lje_LowerJejunum_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="harsFHy1eEiQ-1kDQvZx5g" secondNeighbor="BC5XIDg8L0Kh6isr8xLJnw">
-        <Tags>
-          <Tag value="Neighborhood: LowerJejunum / Intracellular" />
-        </Tags>
-        <Children>
-          <Container id="sfqtjAHJtES4ANY5sqz--A" name="MoleculeProperties" mode="Logical" containerType="Other">
-            <Children>
-              <Parameter id="GaGeu_jiqE-3kpVqCSUzzQ" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K2" isDefault="1">
-                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              <Parameter id="xm6oqM88vESjJAZijBzR9w" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_LowerJejunum" isDefault="1">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
               </Parameter>
-              <Parameter id="97NDRRHuw0utHrJ0ua2jRQ" name="pKa_pH_WS_cell_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K3" isDefault="1">
+              <Parameter id="f5Yz_vuM5kK0BcwYs-Gwqw" name="pKa_pH_WS_cell_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F1" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="mwxPzysXzE2DSt7by6nQ0w" name="pKa_pH_WS_cell_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K4" isDefault="1">
+              <Parameter id="FlxKFPez6EWnV0acZkUZ5A" name="pKa_pH_WS_cell_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F2" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="j5mYWA5wB0KeQ030oKGpQQ" name="pKa_pH_WS_cell_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K5" isDefault="1">
+              <Parameter id="KL4sIrCij0SPtRTOIJFhzg" name="pKa_pH_WS_cell_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F3" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="M_7w_uNXdk2ehFdHMmIqzQ" name="pKa_pH_WS_cell_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K6" isDefault="1">
+              <Parameter id="eHehMsPuMU6JQSvmalEAAQ" name="pKa_pH_WS_cell_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K1" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="faPKAqR3gU261m3PuCFrqw" name="pKa_pH_WS_cell_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K7" isDefault="1">
+              <Parameter id="tzHnOGDTf0yTa8yuEq6xPQ" name="pKa_pH_WS_cell_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K2" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="eXys250n4UW-8tF_HG67Aw" name="pKa_pH_WS_cell_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K8" isDefault="1">
+              <Parameter id="Dl_xi317v06E768EAx9fYQ" name="pKa_pH_WS_cell_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K3" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="FKZfCMWgZEKW1LBR8nwT0g" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F1" isDefault="1">
+              <Parameter id="QvO5-CsWOkOO7ueR_pTYQw" name="pKa_pH_WS_cell_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K4" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="ZIedP70vw0uqUAI2DsFnHQ" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F2" isDefault="1">
+              <Parameter id="2yElfp_J3ky4-dsN7Q66-g" name="pKa_pH_WS_cell_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K5" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="SGNHSrPqo0CnnXDC8zggAQ" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K1" isDefault="1">
+              <Parameter id="LszJgk9yuECPWPvXB7O5Jg" name="pKa_pH_WS_cell_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K6" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="gpVvJvuaZE6tISJZ36hObQ" name="pKa_pH_WS_cell_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F3" isDefault="1">
+              <Parameter id="AE16iNlOWUO426MIL1rJbA" name="pKa_pH_WS_cell_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K7" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="3l5Y4LeXaU2FlmHuZ12wFA" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K3" isDefault="1">
+              <Parameter id="Xpt2RSbroUuk7XraJn9-jg" name="pKa_pH_WS_cell_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K8" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="wR99u5pPhkezxUfQh8DP3g" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K4" isDefault="1">
+              <Parameter id="QKykmhjx6kiYvgzG_yYnyw" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F1" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="NgUMRb3-b0qJ2a-bMNFYWA" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K5" isDefault="1">
+              <Parameter id="44rpHo5-YUK-VwOd6j8vrw" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F2" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="rW6uxscEoUanutIIyPEUww" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K6" isDefault="1">
+              <Parameter id="gpT7-K5iT0q8cnViXWdceQ" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F3" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="9sVScX6aSkO8bczbi_8MVw" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K7" isDefault="1">
+              <Parameter id="fxv_P_5zskWSDJa4da5yQQ" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K1" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="jvhGjzUVXkaS0b8SNo8TDA" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K8" isDefault="1">
+              <Parameter id="EyvTtwPffEWLhFpHJ1TcJg" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K2" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="gLZlkAb5sEaVnd4czhAeQw" name="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" isDefault="1" displayUnit="µmol/min">
-                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
-              </Parameter>
-              <Parameter id="g_e99SOH9kCF9BlZBzmWnw" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F3" isDefault="1">
+              <Parameter id="gcLnei65WE6a5v6pwVuq7Q" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K3" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="TUu0O8wLLkaJBH66bry5tg" name="pKa_pH_WS_cell_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K2" isDefault="1">
+              <Parameter id="6AZfKOIjEEq3xGGOGWbunA" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K4" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="lK2FSYfV1USE1FmJczquiA" name="pKa_pH_WS_cell_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K1" isDefault="1">
+              <Parameter id="WLT3Yzpr-UW8q2HZV60r0Q" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K5" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="-0dj1VZnDkiFE1vWk5IeOA" name="Drug absorption rate (lumen to mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_DrugAbsorption_trans" isDefault="1" displayUnit="µmol/min">
-                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
-              </Parameter>
-              <Parameter id="uhV6l5Th_k2mo0PxoZxwcw" name="P_int_trans_cell_lum_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_cell_lum_factor" isDefault="1">
+              <Parameter id="y2FKhChwwkidJ0VTbqUNhw" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K6" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="q-0itaXjHkWsioiS3ENFfQ" name="P_int_trans_lum_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_lum_cell_factor" isDefault="1">
+              <Parameter id="MDngTlk6C0e6METtCUdnrw" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K7" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="JEHnq19AUUObuhOlflz7Ww" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_K_cell_pls_LowerJejunum" isDefault="1">
-                <Info min="0" flag="36" seq="1" ref="0" bb="2" group="67" />
-              </Parameter>
-              <Parameter id="zbrRVDZQW0GhSMCQYASY7w" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_LowerJejunum" isDefault="1">
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
-              </Parameter>
-              <Parameter id="bAvw6fldfUabAwxO5M5iBQ" name="pKa_pH_WS_cell_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F1" isDefault="1">
+              <Parameter id="8IRlagv4qESilXqpAmfEtg" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K8" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="sdW3oSZhbkuA6avEbYg_mA" name="pKa_pH_WS_cell_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F2" isDefault="1">
-                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              <Parameter id="EMpbe5HGHEi-dSNcTIFcug" name="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" isDefault="1" displayUnit="µmol/min">
+                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
               </Parameter>
-              <Parameter id="g1fcC_7WEEGVnFv6UKCjLQ" name="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" isDefault="1" displayUnit="µmol/min">
+              <Parameter id="yzjm6Sij40Ge0Vg4RRevMw" name="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" isDefault="1" displayUnit="µmol/min">
                 <Info flag="52" seq="1" ref="0" bb="2" group="117" />
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-      <NeighborhoodBuilder id="R6arOMTPqUGBQ2qxl9AkhA" name="Lumen_lje_LowerJejunum_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="harsFHy1eEiQ-1kDQvZx5g" secondNeighbor="-tHCOtnB1U2z7aMrUzfzJQ">
+      <NeighborhoodBuilder id="lPhJKnVZ3UWl5w9cp1Wbgw" name="LowerJejunum_pls_PortalVein_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="9M_w50lqQkq4lTBvJwwuig" secondNeighbor="d626iVqs-ESin5Db2bAqWg">
         <Tags>
-          <Tag value="Neighborhood: LowerJejunum / Plasma" />
+          <Tag value="Neighborhood: Plasma / Plasma" />
         </Tags>
         <Children>
-          <Container id="e5rejyTjtU2QY3lTFGm4Mw" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="FYU60ov8V0mlPpH8Zj52Og" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="bDK2rnOkoEyAzMbi6zVWNg" name="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" isDefault="1" displayUnit="µmol/min">
-                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
-              </Parameter>
-              <Parameter id="qDMFMDtPNEOTGnBnExXrAA" name="Drug absorption rate (lumen to mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_DrugAbsorption_para" isDefault="1" displayUnit="µmol/min">
+              <Parameter id="NzX6ZfRAj0qFgrZElUCadA" name="Mass transfer rate (mucosa to portal vein plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_forTwoPores.PARAM_MassTransferMucosaToPvePlasma" isDefault="1" displayUnit="µmol/min">
+                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                 <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
               </Parameter>
-              <Parameter id="346VZc0wHEyqTXgSK7I5fQ" name="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" isDefault="1" displayUnit="µmol/min">
-                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
-              </Parameter>
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         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="Qw8FSWR3902WAYNEBkL36Q" name="Lumen_duo_Lumen_uje" mode="Logical" containerType="Neighborhood" firstNeighbor="Soy8bWRBA0aKD_xjTO8QdQ" secondNeighbor="z54PqeD3mkafETZ2sl_c1A">
+      <NeighborhoodBuilder id="wxcMzlB_pUuojGycqrxpnQ" name="LowerJejunum_bc_PortalVein_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="agnOGTrLQES0KmSTwvqI5w" secondNeighbor="J7qhrNHWA0i3ePh_JHm2LQ">
         <Tags>
-          <Tag value="Neighborhood: Duodenum / UpperJejunum" />
+          <Tag value="Neighborhood: BloodCells / BloodCells" />
         </Tags>
         <Children>
-          <Container id="_uFqZPdREUWb5qeO5Y1KYg" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="ZFwv6evgTU6oAompvuyWhA" name="MoleculeProperties" mode="Logical" containerType="Other">
+            <Children>
+              <Parameter id="7sgvcZZP9E-DaQkEeGIMGw" name="Mass transfer rate (mucosa to portal vein blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_forTwoPores.PARAM_MassTransferMucosaToPveBloodCells" isDefault="1" displayUnit="µmol/min">
+                <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+              </Parameter>
+            </Children>
+          </Container>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="QFmjM_FI3U2At-n6K9pENg" name="Lumen_sto_Lumen_duo" mode="Logical" containerType="Neighborhood" firstNeighbor="B0bd84_dikGJke9sgqiyyg" secondNeighbor="Soy8bWRBA0aKD_xjTO8QdQ">
+      <NeighborhoodBuilder id="MIMFqr5KTUm8l4eY25CHjw" name="Lumen_sto_Lumen_duo" mode="Logical" containerType="Neighborhood" firstNeighbor="dtzfXSPsqUGUqYC_ZVUnsg" secondNeighbor="Q2OaqR8Xk0-oRedeXkkAcA">
         <Tags>
           <Tag value="Neighborhood: Stomach / Duodenum" />
         </Tags>
         <Children>
-          <Container id="DxKikiGnxUOAIuBFqdqlFw" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="TYZ9rvZPtku4DnUjc3rvZg" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="iIrafpKTYkCH4bdx-D8yEA" name="Oral mass absorbed" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_OralMassAbsorbed" isDefault="1" displayUnit="µmol">
+              <Parameter id="WRZjsNdMGk2dwMVT1Trs5A" name="Oral mass absorbed" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_OralMassAbsorbed" isDefault="1" displayUnit="µmol">
                 <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
               </Parameter>
             </Children>
           </Container>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="L-sF9HPGAUOdVXVPfTEmAw" name="Lumen_uje_Lumen_lje" mode="Logical" containerType="Neighborhood" firstNeighbor="z54PqeD3mkafETZ2sl_c1A" secondNeighbor="harsFHy1eEiQ-1kDQvZx5g">
+      <NeighborhoodBuilder id="h9WTo_HEsk22uHmxtJYiGg" name="Lumen_duo_Lumen_uje" mode="Logical" containerType="Neighborhood" firstNeighbor="Q2OaqR8Xk0-oRedeXkkAcA" secondNeighbor="LPz6GLczUEWKm6sHP_khAQ">
         <Tags>
-          <Tag value="Neighborhood: UpperJejunum / LowerJejunum" />
+          <Tag value="Neighborhood: Duodenum / UpperJejunum" />
         </Tags>
         <Children>
-          <Container id="ZGgIE50Xs0SGzckRx8dQoQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="H7ZmdsL7ZUe4EVn4dPB6kQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="o3IJzW4yWk-1-2RzPy_6ew" name="Lumen_lje_Lumen_uil" mode="Logical" containerType="Neighborhood" firstNeighbor="harsFHy1eEiQ-1kDQvZx5g" secondNeighbor="Ihg_wnyKDky6HlnEBLVT1A">
+      <NeighborhoodBuilder id="a-hV7T6g60iqOWH6mlM_Tw" name="Lumen_uje_Lumen_lje" mode="Logical" containerType="Neighborhood" firstNeighbor="LPz6GLczUEWKm6sHP_khAQ" secondNeighbor="Ngf59qCHkEOYMMJTcfumlw">
         <Tags>
-          <Tag value="Neighborhood: LowerJejunum / UpperIleum" />
+          <Tag value="Neighborhood: UpperJejunum / LowerJejunum" />
         </Tags>
         <Children>
-          <Container id="fjoeZ4IU3UyMIGr04DrQHA" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="mWHq7rfzFkWxLFIv5GDDEQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="h2NWSYyZHEeuHzhVLm4nKw" name="LowerJejunum_pls_PortalVein_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="-tHCOtnB1U2z7aMrUzfzJQ" secondNeighbor="5TpyW0Sd9USQGXc2frzUgA">
+      <NeighborhoodBuilder id="hjKceImDKUOYaEl-O1iI4A" name="Lumen_lje_Lumen_uil" mode="Logical" containerType="Neighborhood" firstNeighbor="Ngf59qCHkEOYMMJTcfumlw" secondNeighbor="YontS4KffU69B65vcA06_A">
         <Tags>
-          <Tag value="Neighborhood: Plasma / Plasma" />
+          <Tag value="Neighborhood: LowerJejunum / UpperIleum" />
         </Tags>
         <Children>
-          <Container id="6yYeCa0gN0m9qIzYPatM-A" name="MoleculeProperties" mode="Logical" containerType="Other">
-            <Children>
-              <Parameter id="IC6ixsYZRkOEy0NU_1G-1Q" name="Mass transfer rate (mucosa to portal vein plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_forTwoPores.PARAM_MassTransferMucosaToPvePlasma" isDefault="1" displayUnit="µmol/min">
-                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
-              </Parameter>
-            </Children>
-          </Container>
+          <Container id="BY9c8MN06US_2qlZ82ykZA" name="MoleculeProperties" mode="Logical" containerType="Other" />
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       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="sr6gFkfAokCsmTwm1smc4w" name="LowerJejunum_bc_PortalVein_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="Fzo84SjMx0Ck9ipgh_6h1w" secondNeighbor="oz2_zRPfzk-ZhQqUyIQ6kg">
+      <NeighborhoodBuilder id="s84fEa5nb0G837dQck1KbA" name="Lumen_uil_Lumen_lil" mode="Logical" containerType="Neighborhood" firstNeighbor="YontS4KffU69B65vcA06_A" secondNeighbor="C_Q1ZtRcwUSAmwuymmvd1A">
         <Tags>
-          <Tag value="Neighborhood: BloodCells / BloodCells" />
+          <Tag value="Neighborhood: UpperIleum / LowerIleum" />
         </Tags>
         <Children>
-          <Container id="XRXAH9tzskiZVv-PR8df4Q" name="MoleculeProperties" mode="Logical" containerType="Other">
-            <Children>
-              <Parameter id="3PwEWwKLC0SBPegNwr45LQ" name="Mass transfer rate (mucosa to portal vein blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_forTwoPores.PARAM_MassTransferMucosaToPveBloodCells" isDefault="1" displayUnit="µmol/min">
-                <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
-                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
-              </Parameter>
-            </Children>
-          </Container>
+          <Container id="g226komy2kewVyFAjXXh6A" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="yxy8Ae1bdE6cMMvwALm7bA" name="Lumen_uil_Lumen_lil" mode="Logical" containerType="Neighborhood" firstNeighbor="Ihg_wnyKDky6HlnEBLVT1A" secondNeighbor="eM1zn7TZCkyCHMf6OsbM0Q">
+      <NeighborhoodBuilder id="zY54hLuYWUuohhBjqmLtFA" name="Lumen_lil_Lumen_cae" mode="Logical" containerType="Neighborhood" firstNeighbor="C_Q1ZtRcwUSAmwuymmvd1A" secondNeighbor="YtQbk7tJX0SRGBH7l7Mvow">
         <Tags>
-          <Tag value="Neighborhood: UpperIleum / LowerIleum" />
+          <Tag value="Neighborhood: LowerIleum / Caecum" />
         </Tags>
         <Children>
-          <Container id="a5JCGUCHiEetLqdThqg0Yw" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="fsFRiFKrx0qGxemmgd3UIQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="5YBDdJZhyku1FQ_y8rAtbQ" name="Lumen_lil_Lumen_cae" mode="Logical" containerType="Neighborhood" firstNeighbor="eM1zn7TZCkyCHMf6OsbM0Q" secondNeighbor="g73FHixAbke8T8DjmH5heQ">
-        <Tags>
-          <Tag value="Neighborhood: LowerIleum / Caecum" />
-        </Tags>
-        <Children>
-          <Container id="xyRBSmloaE6Lof-Bgr-aVA" name="MoleculeProperties" mode="Logical" containerType="Other" />
-        </Children>
-      </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="-H1nsCbmQU6NBGoI5tpYMw" name="Lumen_cae_Lumen_colasc" mode="Logical" containerType="Neighborhood" firstNeighbor="g73FHixAbke8T8DjmH5heQ" secondNeighbor="alASnwRuBk-kXDoH0sPohw">
+      <NeighborhoodBuilder id="QmnhVkz3hUi587JlBlZ8uA" name="Lumen_cae_Lumen_colasc" mode="Logical" containerType="Neighborhood" firstNeighbor="YtQbk7tJX0SRGBH7l7Mvow" secondNeighbor="IIG08bkIP0mqw9u39eWCjA">
         <Tags>
           <Tag value="Neighborhood: Caecum / ColonAscendens" />
         </Tags>
         <Children>
-          <Container id="uU0QkZT7XEq0R7Av9-Fc_Q" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="yLm0Oeo000C3M3nzX2krmQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="BNCCncupGUCp0T6cjFEedA" name="Lumen_colasc_Lumen_coltrans" mode="Logical" containerType="Neighborhood" firstNeighbor="alASnwRuBk-kXDoH0sPohw" secondNeighbor="ie3h9CgxCU284p0wLjL9fw">
+      <NeighborhoodBuilder id="DWGCQgsL2kuIJJ4cmI3E8w" name="Lumen_colasc_Lumen_coltrans" mode="Logical" containerType="Neighborhood" firstNeighbor="IIG08bkIP0mqw9u39eWCjA" secondNeighbor="gOwWT2AqWk2pbTe4eeu9iw">
         <Tags>
           <Tag value="Neighborhood: ColonAscendens / ColonTransversum" />
         </Tags>
         <Children>
-          <Container id="TtWiwVJzmkauKH5Jlwc4RA" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="1Zz0PsOxkEa3pcW0bYArAA" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="eVLwQRDMg0eTnbCQQEl0cg" name="Lumen_coltrans_Lumen_coldesc" mode="Logical" containerType="Neighborhood" firstNeighbor="ie3h9CgxCU284p0wLjL9fw" secondNeighbor="YZUlLOUbckymPftQV_qzhg">
+      <NeighborhoodBuilder id="Fs3lKJ9F-kiWm8cLRIUl6w" name="Lumen_coltrans_Lumen_coldesc" mode="Logical" containerType="Neighborhood" firstNeighbor="gOwWT2AqWk2pbTe4eeu9iw" secondNeighbor="swnURfirP0a_IppunMKLQA">
         <Tags>
           <Tag value="Neighborhood: ColonTransversum / ColonDescendens" />
         </Tags>
         <Children>
-          <Container id="FzVkQk9vXkCBfuxtHSnSRw" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="IfDZ1WsPAkadzpczZAmRWw" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="hSZe8MZW9kang4vTFkbcsg" name="Lumen_coldesc_Lumen_colsigm" mode="Logical" containerType="Neighborhood" firstNeighbor="YZUlLOUbckymPftQV_qzhg" secondNeighbor="B12kRDWtqUGL5miHA0Saxg">
+      <NeighborhoodBuilder id="JeDrq17-P0-4wnO06rLl6g" name="Lumen_coldesc_Lumen_colsigm" mode="Logical" containerType="Neighborhood" firstNeighbor="swnURfirP0a_IppunMKLQA" secondNeighbor="8EVK1diXzEKNlC-Y6QOZJg">
         <Tags>
           <Tag value="Neighborhood: ColonDescendens / ColonSigmoid" />
         </Tags>
         <Children>
-          <Container id="yV5Hi_y2rkSjT9Yseh9Y2w" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="9MzZCBJxKEWYcCWrlXuh6w" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="IkvWa6ePoESwoTtk-dTV9g" name="Lumen_colsigm_Lumen_rect" mode="Logical" containerType="Neighborhood" firstNeighbor="B12kRDWtqUGL5miHA0Saxg" secondNeighbor="N4-kBR_40ku5rWhp0VEzqA">
+      <NeighborhoodBuilder id="vHNqt4yeskK_SvD5HEfJhQ" name="Lumen_colsigm_Lumen_rect" mode="Logical" containerType="Neighborhood" firstNeighbor="8EVK1diXzEKNlC-Y6QOZJg" secondNeighbor="94Sc5RUGNUaXs_bDJ2T7lQ">
         <Tags>
           <Tag value="Neighborhood: ColonSigmoid / Rectum" />
         </Tags>
         <Children>
-          <Container id="Txeqn28WXEWedH8jsMB5ww" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="7x4M3Vkr40u31AXnX0PDvg" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="O4hn-PjEH02r1XK1QgZHNw" name="Lumen_rect_Lumen_fec" mode="Logical" containerType="Neighborhood" firstNeighbor="N4-kBR_40ku5rWhp0VEzqA" secondNeighbor="9lTL_VWE0Ui8vKfdUBrZDQ">
+      <NeighborhoodBuilder id="4hMNJXbM8UWMmyhmNQWHrQ" name="Lumen_rect_Lumen_fec" mode="Logical" containerType="Neighborhood" firstNeighbor="94Sc5RUGNUaXs_bDJ2T7lQ" secondNeighbor="ffDERjBcLEWuvmggak6aTQ">
         <Tags>
           <Tag value="Neighborhood: Rectum / Feces" />
         </Tags>
         <Children>
-          <Container id="LMEvPmu7sUyVHAdBSox-_A" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="Ov2ChBpvMUepNNUXNJA10g" name="MoleculeProperties" mode="Logical" containerType="Other" />
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="cnl_QaaSS0e-Azy54UIZKg" name="Stomach_bc_PortalVein_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="r-N8X-cLkE-cKfvE0t6EKQ" secondNeighbor="J7qhrNHWA0i3ePh_JHm2LQ">
+        <Tags>
+          <Tag value="Neighborhood: BloodCells / BloodCells" />
+        </Tags>
+        <Children>
+          <Container id="BpOChCn7nUCD6YNOhqAVnw" name="MoleculeProperties" mode="Logical" containerType="Other" />
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="xttc1uJkYES_oF5ZbcXMDQ" name="Stomach_end_Stomach_ecl" mode="Logical" containerType="Neighborhood" firstNeighbor="NSFAoupKckm-s-PO7GFRdg" secondNeighbor="0MjJnhA0s063jmqn9J-j4Q">
+        <Tags>
+          <Tag value="Neighborhood: Endosome / EndosomalClearance" />
+        </Tags>
+        <Children>
+          <Container id="YcRDWpxT00-8I4RRPeCBww" name="MoleculeProperties" mode="Logical" containerType="Other" />
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="FYpk8Rvg9UGz322dePPFRA" name="Stomach_end_Stomach_int" mode="Logical" containerType="Neighborhood" firstNeighbor="NSFAoupKckm-s-PO7GFRdg" secondNeighbor="idjRJQZ_5EiU4vye5ioKFQ">
+        <Tags>
+          <Tag value="Neighborhood: Endosome / Interstitial" />
+        </Tags>
+        <Children>
+          <Container id="epNbNAJxLUSx_eIK5Mq_ow" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="K2c4-YGQeUO0UQ9qAJe19g" name="Stomach_int_Stomach_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="QsTD2RCqr0Ksj0JSvzHRSQ" secondNeighbor="1RoONqsRC0e5g1N6_B_eSw">
+      <NeighborhoodBuilder id="Fg_0uz1dpUubFyhmY3EyOg" name="Stomach_int_Stomach_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="idjRJQZ_5EiU4vye5ioKFQ" secondNeighbor="DvjhtxZc7k-0GXmDzJwKBQ">
         <Tags>
           <Tag value="Neighborhood: Interstitial / Intracellular" />
         </Tags>
         <Children>
-          <Container id="JNoSYQ-d9kyvQA8XpSVPRA" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="N4CscyRjcEiZigdDhK8FVg" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="y3S_AGBZjEi0Rm3fCLhzzg" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
-              </Parameter>
-              <Parameter id="SNd2Ie0g2USYjI5FyKJP3g" name="P (interstitial-&gt;intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" isDefault="1" displayUnit="cm/min">
+              <Parameter id="60vlmREbPEWcbvxF3vMrNQ" name="P (interstitial-&gt;intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" isDefault="1" displayUnit="cm/min">
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="78" />
               </Parameter>
-              <Parameter id="AGpvEfUW5k26AtqKlp11iw" name="P (intracellular-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" isDefault="1" displayUnit="cm/min">
+              <Parameter id="HQ4-zKal00GFlZc0hxee2g" name="P (intracellular-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" isDefault="1" displayUnit="cm/min">
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="76" />
               </Parameter>
-              <Parameter id="3Y-toc-STEuRA74xigQixw" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
+              <Parameter id="crxUQqVL0Ey9QvBOPgkyhg" name="P*SA interstitial -&gt; intracellular" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" isDefault="1" displayUnit="l/min">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="nFdfUB2JXESj5jSNu8o5wg" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="JmCoUaYE70yb4Z4QDPsagQ" name="P*SA interstitial -&gt; intracellular" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" isDefault="1" displayUnit="l/min">
+              <Parameter id="a1ozECkWwk2aupOLjgWvhA" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="vy6gvFSlp0SHufcc0WHpbA" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
+              <Parameter id="CWEcgErEfU22d3jsD5AzKw" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="QXgPb3KoGU6jEdc2eHbMhg" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
+              <Parameter id="_OOBWi_Ny0aZ6tNtUXp9AQ" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="69" />
               </Parameter>
-              <Parameter id="umSjPk6XPU2wjgnNdwC1UA" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
+              <Parameter id="bPeroGpFi0G2LX9Inu9I3w" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
               </Parameter>
             </Children>
           </Container>
-          <Parameter id="a26I9TPWbECmVfjqNc-dBQ" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_sto" isDefault="1" displayUnit="cm²">
+          <Parameter id="VVdKYGCRAkSawiSryPM-sg" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_sto" isDefault="1" displayUnit="cm²">
             <Tags>
               <Tag value="Neighborhood: Interstitial / Intracellular" />
             </Tags>
@@ -17760,193 +17857,93 @@
           </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="302eOrvipk-wdL7B3zfl5A" name="Stomach_end_Stomach_int" mode="Logical" containerType="Neighborhood" firstNeighbor="ISBNb6AmZkqpaut8DG_4Aw" secondNeighbor="QsTD2RCqr0Ksj0JSvzHRSQ">
-        <Tags>
-          <Tag value="Neighborhood: Endosome / Interstitial" />
-        </Tags>
-        <Children>
-          <Container id="eQ3z1NHExEi7O4CGKaWWaQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
-        </Children>
-      </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="viYr-EPiKkKUPG2Ml__SLA" name="Stomach_end_Stomach_ecl" mode="Logical" containerType="Neighborhood" firstNeighbor="ISBNb6AmZkqpaut8DG_4Aw" secondNeighbor="eDJJFajIZ0qqc5SSL9V05w">
-        <Tags>
-          <Tag value="Neighborhood: Endosome / EndosomalClearance" />
-        </Tags>
-        <Children>
-          <Container id="zQLDUksSjEiXmJKa23AT1w" name="MoleculeProperties" mode="Logical" containerType="Other" />
-        </Children>
-      </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="Km5Bhx9cT0uvJ9m5ggP7rA" name="Stomach_bc_PortalVein_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="QHLwcgIuSUOTxRH2jLvoJw" secondNeighbor="oz2_zRPfzk-ZhQqUyIQ6kg">
+      <NeighborhoodBuilder id="E0LPJtH0sU6dccEAsulqMw" name="Stomach_int_VenousBlood_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="idjRJQZ_5EiU4vye5ioKFQ" secondNeighbor="JxP9aCWtgUGhXH_R7w1Z2Q">
         <Tags>
-          <Tag value="Neighborhood: BloodCells / BloodCells" />
+          <Tag value="Neighborhood: Interstitial / Plasma" />
         </Tags>
         <Children>
-          <Container id="X7Xchi3iSk6xMaMflxWrtQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="3c4X-dUdGkG9vJSGS7TeiA" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="ogKQYb_NIUGzHItbw-iJuA" name="Lumen_uil_UpperIleum_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="Ihg_wnyKDky6HlnEBLVT1A" secondNeighbor="HuwaRp7cAkOPSAeW5XiPPQ">
+      <NeighborhoodBuilder id="d8LvIH7cO0mCJw2tQXE6_w" name="Stomach_pls_PortalVein_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="1Y1b2vLN9kKD2bFVFJvlPA" secondNeighbor="d626iVqs-ESin5Db2bAqWg">
         <Tags>
-          <Tag value="Neighborhood: UpperIleum / Intracellular" />
+          <Tag value="Neighborhood: Plasma / Plasma" />
         </Tags>
         <Children>
-          <Container id="b34W--1v80iiGAgmrljx0A" name="MoleculeProperties" mode="Logical" containerType="Other">
-            <Children>
-              <Parameter id="Ty5ZSu4wCkqzauix-N5LZg" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K5" isDefault="1">
-                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
-              </Parameter>
-              <Parameter id="JkKHqaPplkun0vvs52j8Ow" name="pKa_pH_WS_cell_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K6" isDefault="1">
-                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
-              </Parameter>
-              <Parameter id="8bQOLnQKBE--zv_F0hPU7Q" name="pKa_pH_WS_cell_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K7" isDefault="1">
-                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
-              </Parameter>
-              <Parameter id="CUBAKZzUAku7fioDZ-4GYg" name="pKa_pH_WS_cell_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K8" isDefault="1">
-                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
-              </Parameter>
-              <Parameter id="tB9abvhKlEuUvOTfCR8-0w" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F1" isDefault="1">
-                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
-              </Parameter>
-              <Parameter id="dK1tFwZTxkSNRwWvUP_awg" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F2" isDefault="1">
-                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
-              </Parameter>
-              <Parameter id="koT1Ov8ZOUum8Y_cQGWDsw" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F3" isDefault="1">
-                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
-              </Parameter>
-              <Parameter id="9y8anE1CRU2Jjl9xJKi35Q" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K1" isDefault="1">
-                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
-              </Parameter>
-              <Parameter id="l97aa2-Zrkuff6VbE1f5dA" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K2" isDefault="1">
-                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
-              </Parameter>
-              <Parameter id="Uy7Sv97Um0W8MPLCKPL2SA" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K4" isDefault="1">
-                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
-              </Parameter>
-              <Parameter id="KZbPgU0LPUeLAt9SzeeAFw" name="pKa_pH_WS_cell_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K3" isDefault="1">
-                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
-              </Parameter>
-              <Parameter id="SuI-beAkqEKG38CWiWFe4g" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K6" isDefault="1">
-                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
-              </Parameter>
-              <Parameter id="Wt2JLnrprk-HmwYA4pRwLA" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K7" isDefault="1">
-                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
-              </Parameter>
-              <Parameter id="6X-puSo3UUK0oXZDpG5ZVg" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K8" isDefault="1">
-                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
-              </Parameter>
-              <Parameter id="ygGneSlvM06-33EZVewIpQ" name="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" isDefault="1" displayUnit="µmol/min">
-                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
-              </Parameter>
-              <Parameter id="lPXQ4nL4QEqQvsffyMlagA" name="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" isDefault="1" displayUnit="µmol/min">
-                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
-              </Parameter>
-              <Parameter id="JJ5GK1rVqUGTqVGdZQkDxA" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K3" isDefault="1">
-                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
-              </Parameter>
-              <Parameter id="226PWiki4EKm22SxO67biQ" name="P_int_trans_cell_lum_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_cell_lum_factor" isDefault="1">
-                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
-              </Parameter>
-              <Parameter id="7b16aLA7YUWslfCiSUUk8w" name="pKa_pH_WS_cell_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K5" isDefault="1">
-                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
-              </Parameter>
-              <Parameter id="4j_g8jmCyUuHJiV1XoU8Rg" name="Drug absorption rate (lumen to mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_DrugAbsorption_trans" isDefault="1" displayUnit="µmol/min">
-                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
-              </Parameter>
-              <Parameter id="auPjgY3hfUOLj5fO1w7Ogg" name="pKa_pH_WS_cell_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K4" isDefault="1">
-                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
-              </Parameter>
-              <Parameter id="qtHGJGV0m0ae-pTJ51HMTA" name="P_int_trans_lum_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_lum_cell_factor" isDefault="1">
-                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
-              </Parameter>
-              <Parameter id="dacn6nYPRk-9ye1jDCmdpg" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_K_cell_pls_UpperIleum" isDefault="1">
-                <Info min="0" flag="36" seq="1" ref="0" bb="2" group="67" />
-              </Parameter>
-              <Parameter id="qFj0VMOPu0WCapU9z7pDKQ" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_UpperIleum" isDefault="1">
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
-              </Parameter>
-              <Parameter id="iIwsfhNSkUylhI9KaulopA" name="pKa_pH_WS_cell_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F1" isDefault="1">
-                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
-              </Parameter>
-              <Parameter id="fdUSXew9_Uah_74B2bq6tQ" name="pKa_pH_WS_cell_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F2" isDefault="1">
-                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
-              </Parameter>
-              <Parameter id="_Ud-F7IiAEKcFaA5J98eRQ" name="pKa_pH_WS_cell_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F3" isDefault="1">
-                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
-              </Parameter>
-              <Parameter id="6TVBIeMfUEyfcRIueSEnCw" name="pKa_pH_WS_cell_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K1" isDefault="1">
-                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
-              </Parameter>
-              <Parameter id="vuVnv5nP2Emo3QKqfSFk-g" name="pKa_pH_WS_cell_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K2" isDefault="1">
-                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
-              </Parameter>
-            </Children>
-          </Container>
+          <Container id="FPT-w8Y-cEiYLmCeQ04Rrw" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="D4mgfO1QYU-TVEzP8o6qrw" name="Stomach_pls_PortalVein_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="T-c_8D2_o0S5jdeWnl0JhA" secondNeighbor="5TpyW0Sd9USQGXc2frzUgA">
+      <NeighborhoodBuilder id="rQ3UnpJPaUycTeNUb_qSBg" name="Stomach_pls_Stomach_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="1Y1b2vLN9kKD2bFVFJvlPA" secondNeighbor="r-N8X-cLkE-cKfvE0t6EKQ">
         <Tags>
-          <Tag value="Neighborhood: Plasma / Plasma" />
+          <Tag value="Neighborhood: Plasma / BloodCells" />
         </Tags>
         <Children>
-          <Container id="U2pInT1SV0WB42rFb6sviw" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="Xux7SJVE_Eegi40a00eaBg" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Parameter id="6dr0bmmsx0OYZG0X5OXsTg" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" isDefault="1" displayUnit="cm²">
+            <Tags>
+              <Tag value="Neighborhood: Plasma / BloodCells" />
+            </Tags>
+            <Info min="0" flag="122" seq="20" ref="0" bb="32" group="104" />
+          </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="o2-5UAAMrEKK4RttyPjpkQ" name="Stomach_int_VenousBlood_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="QsTD2RCqr0Ksj0JSvzHRSQ" secondNeighbor="lg3JPjAHSUaKoE7vwc_rTw">
+      <NeighborhoodBuilder id="TW8kt2OI9U-Wy4ARQnu62Q" name="Stomach_pls_Stomach_end" mode="Logical" containerType="Neighborhood" firstNeighbor="1Y1b2vLN9kKD2bFVFJvlPA" secondNeighbor="NSFAoupKckm-s-PO7GFRdg">
         <Tags>
-          <Tag value="Neighborhood: Interstitial / Plasma" />
+          <Tag value="Neighborhood: Plasma / Endosome" />
         </Tags>
         <Children>
-          <Container id="IhAKvICHBkurEjZusqAzkg" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="IJ842H7pOEOjCHheC8ltOg" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="1Rn2DJJbfECn8PUOaZPZ9Q" name="Stomach_pls_Stomach_int" mode="Logical" containerType="Neighborhood" firstNeighbor="T-c_8D2_o0S5jdeWnl0JhA" secondNeighbor="QsTD2RCqr0Ksj0JSvzHRSQ">
+      <NeighborhoodBuilder id="7LRyIhPKYEOMNpKwreXM4A" name="Stomach_pls_Stomach_int" mode="Logical" containerType="Neighborhood" firstNeighbor="1Y1b2vLN9kKD2bFVFJvlPA" secondNeighbor="idjRJQZ_5EiU4vye5ioKFQ">
         <Tags>
           <Tag value="Neighborhood: Plasma / Interstitial" />
         </Tags>
         <Children>
-          <Container id="08atBxmD0USfWqqqvP_1yw" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="p_0N18iKZkGLsd5lTE3lUQ" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="lXfMbC1GJkWOgg3BtemlVg" name="Radius ratio (solute/large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_gamma_l" isDefault="1">
-                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="116" />
-              </Parameter>
-              <Parameter id="Ztnnvfma-kCci2RlVeFwUw" name="P (large endothelial pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial_l" isDefault="1" displayUnit="cm/min">
+              <Parameter id="senS-NWJfUOdpvYXXCk21w" name="P (large endothelial pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial_l" isDefault="1" displayUnit="cm/min">
                 <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="79" />
               </Parameter>
-              <Parameter id="kQSvtFDFfEeoeNDNJ-DuVA" name="P (plasma&lt;-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial" isDefault="1" displayUnit="cm/min">
+              <Parameter id="bnCi9nsu70O04eYrb0PoVw" name="P (plasma&lt;-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial" isDefault="1" displayUnit="cm/min">
                 <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="77" />
               </Parameter>
-              <Parameter id="wrb3FhsykkOdgh5tp_wvXQ" name="P (small endothelial pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial_s" isDefault="1" displayUnit="cm/min">
+              <Parameter id="U9oZLvDMqE2PZHxYxbg8aA" name="P (small endothelial pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial_s" isDefault="1" displayUnit="cm/min">
                 <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="80" />
               </Parameter>
-              <Parameter id="fMr-tejbqU6DHOgx9W9_1w" name="Partition coefficient (interstitial/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" isDefault="1">
+              <Parameter id="sRpuL-mhRkSWTX-iHtAaWw" name="Partition coefficient (interstitial/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" isDefault="1">
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="70" />
               </Parameter>
-              <Parameter id="Nn3iil74pUOF79w9YGl7Ng" name="Peclet number (small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CalcPecletNumber.PecletNumber_s" isDefault="1">
+              <Parameter id="rVTYwbCFrEKMxjm7cLmg7Q" name="Peclet number (large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CalcPecletNumber.PecletNumber_l" isDefault="1">
                 <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="116" />
               </Parameter>
-              <Parameter id="sra-9PFS2U-Aq7YZEadEUA" name="Radius ratio (solute/small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_gamma_s" isDefault="1">
+              <Parameter id="qgzBps5XK0WJsjiCtgttOA" name="Peclet number (small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CalcPecletNumber.PecletNumber_s" isDefault="1">
+                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="116" />
+              </Parameter>
+              <Parameter id="p310H9Bd7kmqEIdCx6q81g" name="Radius ratio (solute/large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_gamma_l" isDefault="1">
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                 <Info min="0" flag="52" seq="1" ref="0" bb="2" group="116" />
               </Parameter>
-              <Parameter id="MKGiGvwq8UW8JHCVoX__xA" name="Reflection coefficient (large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_sigma_l" isDefault="1">
+              <Parameter id="5jpIwrPK8Uu_ik5TerGMVA" name="Radius ratio (solute/small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_gamma_s" isDefault="1">
                 <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-                <Info min="0" flag="58" seq="1" ref="0" bb="2" group="89" />
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="116" />
               </Parameter>
-              <Parameter id="3Jrfh4LnXE-zYSMFgbuFAw" name="Reflection coefficient (small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_sigma_s" isDefault="1">
+              <Parameter id="gCZwF5MZc027TmhRn2LC1A" name="Reflection coefficient (large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_sigma_l" isDefault="1">
                 <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-                <Info min="0" flag="58" seq="1" ref="0" bb="2" group="90" />
+                <Info min="0" flag="58" seq="1" ref="0" bb="2" group="89" />
               </Parameter>
-              <Parameter id="ztekDDj74kqYHtvI3SapgA" name="Peclet number (large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CalcPecletNumber.PecletNumber_l" isDefault="1">
+              <Parameter id="7CYV2-i1JkGlEA6vDwPvMA" name="Reflection coefficient (small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_sigma_s" isDefault="1">
                 <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="116" />
+                <Info min="0" flag="58" seq="1" ref="0" bb="2" group="90" />
               </Parameter>
             </Children>
           </Container>
-          <Parameter id="CVv0DO7INkyCq5xY3JwhJA" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" isDefault="1" displayUnit="cm²">
+          <Parameter id="HzozEt240UyUzgJhEEC4Wg" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" isDefault="1" displayUnit="cm²">
             <Tags>
               <Tag value="Neighborhood: Plasma / Interstitial" />
             </Tags>
@@ -17955,234 +17952,147 @@
           </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="WVZZSLByqUadWlLBo-F1aw" name="Stomach_pls_Stomach_end" mode="Logical" containerType="Neighborhood" firstNeighbor="T-c_8D2_o0S5jdeWnl0JhA" secondNeighbor="ISBNb6AmZkqpaut8DG_4Aw">
-        <Tags>
-          <Tag value="Neighborhood: Plasma / Endosome" />
-        </Tags>
-        <Children>
-          <Container id="3gEJsznHLEO5rrVMrEkqdQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
-        </Children>
-      </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="x8xcJMrFHkSU9gEzUaJ44w" name="Stomach_pls_Stomach_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="T-c_8D2_o0S5jdeWnl0JhA" secondNeighbor="QHLwcgIuSUOTxRH2jLvoJw">
-        <Tags>
-          <Tag value="Neighborhood: Plasma / BloodCells" />
-        </Tags>
-        <Children>
-          <Container id="COqojOXaUkikJyJU8AmlGA" name="MoleculeProperties" mode="Logical" containerType="Other" />
-          <Parameter id="JRGcTt9OHUmXO4EUaHJLdg" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" isDefault="1" displayUnit="cm²">
-            <Tags>
-              <Tag value="Neighborhood: Plasma / BloodCells" />
-            </Tags>
-            <Info min="0" flag="122" seq="20" ref="0" bb="32" group="104" />
-          </Parameter>
-        </Children>
-      </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="22D1JNidnEmu921j7FhJ-A" name="UpperIleum_bc_PortalVein_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="CC0ua551hUe7JcUHHqnPAA" secondNeighbor="oz2_zRPfzk-ZhQqUyIQ6kg">
-        <Tags>
-          <Tag value="Neighborhood: BloodCells / BloodCells" />
-        </Tags>
-        <Children>
-          <Container id="72WmTuydlkenoBeztWt3bA" name="MoleculeProperties" mode="Logical" containerType="Other">
-            <Children>
-              <Parameter id="1oxtAfE2AkCm_Ji-fjfHXA" name="Mass transfer rate (mucosa to portal vein blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_forTwoPores.PARAM_MassTransferMucosaToPveBloodCells" isDefault="1" displayUnit="µmol/min">
-                <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
-                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
-              </Parameter>
-            </Children>
-          </Container>
-        </Children>
-      </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="sDikfcWs2EW1ep3iW-8plw" name="UpperIleum_pls_PortalVein_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="G9IH032whkWAD4-xQKxQ9g" secondNeighbor="5TpyW0Sd9USQGXc2frzUgA">
-        <Tags>
-          <Tag value="Neighborhood: Plasma / Plasma" />
-        </Tags>
-        <Children>
-          <Container id="xVY5S0K33ESacduEzmCb6A" name="MoleculeProperties" mode="Logical" containerType="Other">
-            <Children>
-              <Parameter id="HfX72iuxbkit-JVqq4UiHA" name="Mass transfer rate (mucosa to portal vein plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_forTwoPores.PARAM_MassTransferMucosaToPvePlasma" isDefault="1" displayUnit="µmol/min">
-                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
-              </Parameter>
-            </Children>
-          </Container>
-        </Children>
-      </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="A6r_xu1vKk2OpqlXxAsGpg" name="Lumen_uil_UpperIleum_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="Ihg_wnyKDky6HlnEBLVT1A" secondNeighbor="G9IH032whkWAD4-xQKxQ9g">
+      <NeighborhoodBuilder id="D77Ru6U8EUqxTGd0xVF94w" name="Lumen_uil_UpperIleum_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="YontS4KffU69B65vcA06_A" secondNeighbor="Y68ExXOJX0aelj-tehK5jQ">
         <Tags>
           <Tag value="Neighborhood: UpperIleum / Plasma" />
         </Tags>
         <Children>
-          <Container id="qO7vRx8hA0iX23_c9IiDvQ" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="EyBC6GX9LkiuJ488gihkTw" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="aR31X95QNEW3iK07SxUX4Q" name="Drug absorption rate (lumen to mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_DrugAbsorption_para" isDefault="1" displayUnit="µmol/min">
+              <Parameter id="bqOwAX_lIkuCsT_nWKgPzg" name="Drug absorption rate (lumen to mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_DrugAbsorption_para" isDefault="1" displayUnit="µmol/min">
                 <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
               </Parameter>
-              <Parameter id="8pYKektqlECVNlF9Mqkvyg" name="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" isDefault="1" displayUnit="µmol/min">
+              <Parameter id="HmKNT0gB4EK36IAZNwLl1Q" name="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" isDefault="1" displayUnit="µmol/min">
                 <Info flag="52" seq="1" ref="0" bb="2" group="117" />
               </Parameter>
-              <Parameter id="tUl1nQdUUkexLH2ZW68agQ" name="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" isDefault="1" displayUnit="µmol/min">
+              <Parameter id="xoNzRBBQCk2GPRQSeCk3iQ" name="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" isDefault="1" displayUnit="µmol/min">
                 <Info flag="52" seq="1" ref="0" bb="2" group="117" />
               </Parameter>
             </Children>
           </Container>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="4JxqPoN4jkuUE-w5-jjKjg" name="SmallIntestine_pls_LowerIleum_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="7_ch4FUOPEyotM_fc9eLow" secondNeighbor="5l_5v3Xw3UqMT05WcYN9dg">
+      <NeighborhoodBuilder id="tTUifzE_3k2WsXA9Ec7Q7Q" name="Lumen_uil_UpperIleum_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="YontS4KffU69B65vcA06_A" secondNeighbor="EYZAa4Yzr0StY62D_vb3Aw">
         <Tags>
-          <Tag value="Neighborhood: Plasma / Plasma" />
+          <Tag value="Neighborhood: UpperIleum / Intracellular" />
         </Tags>
         <Children>
-          <Container id="wAgFoS5a2U20tqjgFKX0vw" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="JVErxLL9GUaf7m6Evtvacw" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="6pyqqKsglka-YPu2CDGfJQ" name="Mass transfer rate (intestine to mucosa plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_forTwoPores.PARAM_MassTransferIntestineToMucosaPlasma" isDefault="1" displayUnit="µmol/min">
-                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+              <Parameter id="YCVlUXlo6Ei9tTy9taDtHg" name="Drug absorption rate (lumen to mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_DrugAbsorption_trans" isDefault="1" displayUnit="µmol/min">
                 <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
               </Parameter>
-            </Children>
-          </Container>
-        </Children>
-      </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="cPbpMGNsC0uGRN309PkdLw" name="Lumen_lil_LowerIleum_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="eM1zn7TZCkyCHMf6OsbM0Q" secondNeighbor="5l_5v3Xw3UqMT05WcYN9dg">
-        <Tags>
-          <Tag value="Neighborhood: LowerIleum / Plasma" />
-        </Tags>
-        <Children>
-          <Container id="RUEsAc3QlUm9FQ5IGV16_g" name="MoleculeProperties" mode="Logical" containerType="Other">
-            <Children>
-              <Parameter id="4DwenHnxj0mHgmMW5KvV1Q" name="Drug absorption rate (lumen to mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_DrugAbsorption_para" isDefault="1" displayUnit="µmol/min">
-                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+              <Parameter id="fYT5eioKmU2keAlw1BLMEg" name="P_int_trans_cell_lum_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_cell_lum_factor" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="H7JXSiWmeUS28Vdzx5sQjA" name="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" isDefault="1" displayUnit="µmol/min">
-                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+              <Parameter id="ZbUVTJJyVE-7Eo8YOlf-KA" name="P_int_trans_lum_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_lum_cell_factor" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="bjcSN8VutEizJNeb7EmrZg" name="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" isDefault="1" displayUnit="µmol/min">
-                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+              <Parameter id="mR4i0cm0CUmpziFTj5pOZA" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_K_cell_pls_UpperIleum" isDefault="1">
+                <Info min="0" flag="36" seq="1" ref="0" bb="2" group="67" />
               </Parameter>
-            </Children>
-          </Container>
-        </Children>
-      </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="i8tvHnBudUi459q0NCvd_g" name="Lumen_lil_LowerIleum_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="eM1zn7TZCkyCHMf6OsbM0Q" secondNeighbor="YQIFE44fnUK9EweUet_HyA">
-        <Tags>
-          <Tag value="Neighborhood: LowerIleum / Intracellular" />
-        </Tags>
-        <Children>
-          <Container id="GBS-qP_-a0mK0UFA80nRiw" name="MoleculeProperties" mode="Logical" containerType="Other">
-            <Children>
-              <Parameter id="8iJRL5YKTEqs1eK0ovASOw" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K3" isDefault="1">
-                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              <Parameter id="H7RkNciuVkWLTwznB0zyPg" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_UpperIleum" isDefault="1">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
               </Parameter>
-              <Parameter id="QGu-Ag_jKEiq2KYca61rjw" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K4" isDefault="1">
+              <Parameter id="1YBpcx4z1kaNoqwnAiuqhg" name="pKa_pH_WS_cell_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F1" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="0vsahuv9GUCiFWdNIyWpng" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K5" isDefault="1">
+              <Parameter id="gYWI9lQn2kWM53eHxzDR2Q" name="pKa_pH_WS_cell_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F2" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="s1AeM9doH0a61MqXBKVF3g" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K6" isDefault="1">
+              <Parameter id="14BhIFPh70ixWhH_KZdFUQ" name="pKa_pH_WS_cell_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F3" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="li-m_eC41kqWWEJUEYj24w" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K7" isDefault="1">
+              <Parameter id="cXeyCNdJcEOUUSJOPSlGvw" name="pKa_pH_WS_cell_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K1" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="_701z9UixkCspNqyV_9T9g" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K8" isDefault="1">
+              <Parameter id="I2_EPknFZ0yASVCXhvQ0-Q" name="pKa_pH_WS_cell_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K2" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="wL7FQVnR-0S1gvkNNRpaJg" name="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" isDefault="1" displayUnit="µmol/min">
-                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
-              </Parameter>
-              <Parameter id="UZ6o3h8WYEODVXeNyg6m2A" name="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" isDefault="1" displayUnit="µmol/min">
-                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
-              </Parameter>
-              <Parameter id="uM7YHodF_USoHpIbTvaWGg" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F3" isDefault="1">
+              <Parameter id="Q0XzrsMakEiuTLNVXm9ZKg" name="pKa_pH_WS_cell_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K3" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="Be-7igIDekqZCHBJh2HDeQ" name="pKa_pH_WS_cell_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F3" isDefault="1">
+              <Parameter id="0ZYqoe20UU6zuOuvMFoOCA" name="pKa_pH_WS_cell_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K4" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="7US1TvDxzkOZqMinQknpiQ" name="Drug absorption rate (lumen to mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_DrugAbsorption_trans" isDefault="1" displayUnit="µmol/min">
-                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
-              </Parameter>
-              <Parameter id="UYNqwCJlgU-AE1JDB8nDQw" name="P_int_trans_cell_lum_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_cell_lum_factor" isDefault="1">
+              <Parameter id="1pMUzz-SWUOGhRlXLwueEg" name="pKa_pH_WS_cell_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K5" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="KwFg6EPyy0OiMH7my5xPnw" name="P_int_trans_lum_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_lum_cell_factor" isDefault="1">
+              <Parameter id="7gZhzPmIV0aqZh9GRygKgQ" name="pKa_pH_WS_cell_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K6" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="XnZpYQlwl02ZkKBcycPRaA" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_K_cell_pls_LowerIleum" isDefault="1">
-                <Info min="0" flag="36" seq="1" ref="0" bb="2" group="67" />
-              </Parameter>
-              <Parameter id="PxV2VJIRc0eJtwM9B_izjg" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_LowerIleum" isDefault="1">
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
-              </Parameter>
-              <Parameter id="ofEWlmXyjUiJdmPsT2GQrQ" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K2" isDefault="1">
+              <Parameter id="SX5dye7U8kuEob7IBdpXgQ" name="pKa_pH_WS_cell_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K7" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="o4N_0MXxckKI9YeO-k-syw" name="pKa_pH_WS_cell_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F2" isDefault="1">
+              <Parameter id="gmzOBOGc-0aGaAllIHlvew" name="pKa_pH_WS_cell_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K8" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="QdnQFnD-S0aiQllwOWD6BA" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K1" isDefault="1">
+              <Parameter id="FDL0_Ai5TkKGhl4tFLlCxg" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F1" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="H3rosjEHqU-_ppiRnwxKgg" name="pKa_pH_WS_cell_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K1" isDefault="1">
+              <Parameter id="twnwIDkZFEevuUjJaAkI4Q" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F2" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="3X5slgSao02leqj5_5Z5MA" name="pKa_pH_WS_cell_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K2" isDefault="1">
+              <Parameter id="3nAoclvepEml6jIiozKAQg" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F3" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="HrBm3p6mTE-eNZM20ocCkQ" name="pKa_pH_WS_cell_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K3" isDefault="1">
+              <Parameter id="FOW2GWxJtUmlWTwhRl43UA" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K1" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="Mkjhxhy1e0WRehrLTZEV4w" name="pKa_pH_WS_cell_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K4" isDefault="1">
+              <Parameter id="yrTca71l0EuHgdDmz-I12A" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K2" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="KJME7X_MdUSJEJqwVuC6pQ" name="pKa_pH_WS_cell_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K5" isDefault="1">
+              <Parameter id="xxn5QA3LyUC-hIAmgZQd0w" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K3" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="mIfKJkCszEWY_dgeyY3xig" name="pKa_pH_WS_cell_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K6" isDefault="1">
+              <Parameter id="n45VTJQtRUupa9gQCQMclA" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K4" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="DLo3Pq4kGUuffthrHsNcjg" name="pKa_pH_WS_cell_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K7" isDefault="1">
+              <Parameter id="4BM_rjHLa0imCenGstcjeQ" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K5" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="jsWZtwjEJkWyY53mXd94iA" name="pKa_pH_WS_cell_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K8" isDefault="1">
+              <Parameter id="Me7obliUZ0mcDXuwj_2c_g" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K6" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="olG0aFgQ7U-U2Kq574xqUg" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F1" isDefault="1">
+              <Parameter id="HdkhPG2dXkGFouu3yLXgIA" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K7" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="4X6YtP0hcE2yyR7cMrVLSg" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F2" isDefault="1">
+              <Parameter id="pEnezIePMUS3JQ821f0izw" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K8" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="fgZJS8v-vEG2XPQn8BWWDw" name="pKa_pH_WS_cell_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F1" isDefault="1">
-                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              <Parameter id="vR-DzOMtCUuKcaJEYR3BTQ" name="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" isDefault="1" displayUnit="µmol/min">
+                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
+              <Parameter id="D_2M1vTy0EmvhVvtAEvzVw" name="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" isDefault="1" displayUnit="µmol/min">
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-              <Parameter id="6Ic-HmUMCkuLvM5e2Luv1Q" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
+              <Parameter id="2vB5H8NypE6-EGUhqk22Ag" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="YWWkYxEcaU-UOk_GGILHDw" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
+              <Parameter id="nlsUFFJcbEaTvWnJSMgDbw" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="jwrc9ykmp069s1hkMAt4JQ" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
+              <Parameter id="N92620LLT0e5M9z46hzzaQ" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="GrYawuqPkE6SWcsgLo7bqg" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
+              <Parameter id="oir1Z_AsDkyusvHKzcn8Bg" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="69" />
               </Parameter>
-              <Parameter id="Z4fb4_6B6kKv-UgkLUIbhw" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
+              <Parameter id="8V_D6gelfkubQd4m_2-zUA" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
               </Parameter>
             </Children>
           </Container>
-          <Parameter id="er3RO2dau0Cnlgl4ClWmag" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_sin" isDefault="1" displayUnit="cm²">
+          <Parameter id="q_cCyRM4TEy-yzujBxwc7A" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_sin" isDefault="1" displayUnit="cm²">
             <Tags>
               <Tag value="Neighborhood: Interstitial / Intracellular" />
               <Tag value="Small intestine  neighborhood" />
@@ -18403,319 +18169,159 @@
           </Parameter>
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-      <NeighborhoodBuilder id="txUeX_YSXEqg2A2HZCbCJA" name="SmallIntestine_int_VenousBlood_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="op4R16OuJkqzj5QFf3_G7g" secondNeighbor="lg3JPjAHSUaKoE7vwc_rTw">
+      <NeighborhoodBuilder id="qUyyKXWqfkqGJofbQbCIIQ" name="SmallIntestine_int_VenousBlood_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="8OTpnZ2vf0-zkAYr4QjraA" secondNeighbor="JxP9aCWtgUGhXH_R7w1Z2Q">
         <Tags>
           <Tag value="Neighborhood: Interstitial / Plasma" />
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-      <NeighborhoodBuilder id="C_ETkKaZo0yVKk8cYLozwA" name="SmallIntestine_pls_SmallIntestine_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="7_ch4FUOPEyotM_fc9eLow" secondNeighbor="WBDJlNn9AEuNkbx1JbCoXQ">
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-          <Tag value="Small intestine  neighborhood" />
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-          <Container id="3WkBHdIJQk2g91i5_kK4uQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
-          <Parameter id="w2lNGLP7HUGUrLDyB8nWgQ" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls_sinlin" isDefault="1" displayUnit="cm²">
-            <Tags>
-              <Tag value="Neighborhood: Plasma / BloodCells" />
-              <Tag value="Small intestine  neighborhood" />
-            </Tags>
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-          </Parameter>
-        </Children>
-      </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="NmVLmBMa2k6CInJ5yW6-kQ" name="SmallIntestine_pls_SmallIntestine_int" mode="Logical" containerType="Neighborhood" firstNeighbor="7_ch4FUOPEyotM_fc9eLow" secondNeighbor="op4R16OuJkqzj5QFf3_G7g">
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-          <Tag value="Small intestine  neighborhood" />
-        </Tags>
-        <Children>
-          <Container id="6NXLxKWBEUOHWRQs3u1kAA" name="MoleculeProperties" mode="Logical" containerType="Other">
-            <Children>
-              <Parameter id="pbQ8xvNSN0yLeaG_kWWQ2w" name="P (plasma&lt;-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial" isDefault="1" displayUnit="cm/min">
-                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="77" />
-              </Parameter>
-              <Parameter id="44U4a0ExTUq5Qq3584x2gA" name="P (large endothelial pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial_l" isDefault="1" displayUnit="cm/min">
-                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="79" />
-              </Parameter>
-              <Parameter id="9xQa_ZmuMEWTP-sRtwIOTA" name="P (small endothelial pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial_s" isDefault="1" displayUnit="cm/min">
-                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="80" />
-              </Parameter>
-              <Parameter id="8M1TbJPaTkK2GiL5B4CZ0A" name="Partition coefficient (interstitial/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" isDefault="1">
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="70" />
-              </Parameter>
-              <Parameter id="JZS4w79BG0uWKJLo4v3hhQ" name="Peclet number (large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CalcPecletNumber.PecletNumber_l" isDefault="1">
-                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="116" />
-              </Parameter>
-              <Parameter id="A1p_Z3q6UEqaSYHRluITTA" name="Peclet number (small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CalcPecletNumber.PecletNumber_s" isDefault="1">
-                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="116" />
-              </Parameter>
-              <Parameter id="FqFNU-FdbECu-ODgE11cdg" name="Radius ratio (solute/large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_gamma_l" isDefault="1">
-                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="116" />
-              </Parameter>
-              <Parameter id="xqSJ14PcREWBNOdlA2t1WA" name="Radius ratio (solute/small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_gamma_s" isDefault="1">
-                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
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-              </Parameter>
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-                <Info min="0" flag="58" seq="1" ref="0" bb="2" group="89" />
-              </Parameter>
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-                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
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-              <Tag value="Small intestine  neighborhood" />
-            </Tags>
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-            <Info min="0" flag="122" seq="15" ref="0" bb="32" group="106" />
-          </Parameter>
+          <Container id="hJ7YDuW5k02EWMsSeXfbOA" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="2k_t8JGdP0qyWlZ4PEAv-g" name="SmallIntestine_pls_PortalVein_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="7_ch4FUOPEyotM_fc9eLow" secondNeighbor="5TpyW0Sd9USQGXc2frzUgA">
+      <NeighborhoodBuilder id="Q6vmrKoHLUqeZ1QpZ_3tvA" name="SmallIntestine_pls_PortalVein_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="Bswuw2JsQ0muIVZwkoC_bA" secondNeighbor="d626iVqs-ESin5Db2bAqWg">
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-              </Parameter>
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-              </Parameter>
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-              </Parameter>
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-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
-              </Parameter>
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-              </Parameter>
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-              <Tag value="Large intestine  neighborhood" />
-              <Tag value="Neighborhood: Interstitial / Intracellular" />
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-        </Tags>
-        <Children>
-          <Container id="vOjBuvcxgUKOVY7H9MeEkQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="RUWBcunouEq2_2wn8Z2VUQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
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+      <NeighborhoodBuilder id="nhFAD52MKEyFVLq4hBUADg" name="SmallIntestine_pls_SmallIntestine_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="Bswuw2JsQ0muIVZwkoC_bA" secondNeighbor="vXL46mJIE0uG18PXFjzX5g">
         <Tags>
-          <Tag value="Large intestine  neighborhood" />
           <Tag value="Neighborhood: Plasma / BloodCells" />
+          <Tag value="Small intestine  neighborhood" />
         </Tags>
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-          <Container id="hUgoDYzT6kyUkq_pZieCDA" name="MoleculeProperties" mode="Logical" containerType="Other" />
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+          <Container id="N3208elKf0m98EjSiWdDlQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Parameter id="DYydZ42m3k-OnFlqp-O2kQ" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls_sinlin" isDefault="1" displayUnit="cm²">
             <Tags>
-              <Tag value="Large intestine  neighborhood" />
               <Tag value="Neighborhood: Plasma / BloodCells" />
+              <Tag value="Small intestine  neighborhood" />
             </Tags>
-            <Info min="0" flag="122" seq="9" ref="0" bb="32" group="104" />
+            <Info min="0" flag="122" seq="18" ref="0" bb="32" group="104" />
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+      <NeighborhoodBuilder id="saI_5iJrVkOyzFZCMyGoYg" name="SmallIntestine_pls_SmallIntestine_end" mode="Logical" containerType="Neighborhood" firstNeighbor="Bswuw2JsQ0muIVZwkoC_bA" secondNeighbor="HCab3CYrIESMryRtkcRaXw">
         <Tags>
-          <Tag value="Large intestine  neighborhood" />
           <Tag value="Neighborhood: Plasma / Endosome" />
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-              <Parameter id="JrznwfWXWkmDNDdlBCMq5w" name="Mass transfer rate (intestine to mucosa blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_forTwoPores.PARAM_MassTransferIntestineToMucosaBloodCells" isDefault="1" displayUnit="µmol/min">
+              <Parameter id="YmOvzm6H50eHMwRMaCIF-A" name="Mass transfer rate (intestine to mucosa blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_forTwoPores.PARAM_MassTransferIntestineToMucosaBloodCells" isDefault="1" displayUnit="µmol/min">
                 <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                 <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
               </Parameter>
@@ -18753,14 +18359,14 @@
           </Container>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="X9UORr3oBkWmq8eciNM4EA" name="LargeIntestine_pls_ColonDescendens_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="G9LknYNSJ0CqRovE2-2YJg" secondNeighbor="vL02efQGCU-ZjeiGD2sJSg">
+      <NeighborhoodBuilder id="IzcV1typ6Eij61Iq3pLP6w" name="SmallIntestine_pls_UpperIleum_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="Bswuw2JsQ0muIVZwkoC_bA" secondNeighbor="Y68ExXOJX0aelj-tehK5jQ">
         <Tags>
           <Tag value="Neighborhood: Plasma / Plasma" />
         </Tags>
         <Children>
-          <Container id="R761--0nYUuxzuvzetR8tA" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="FztkR36KuUmMNfXUEKmFnQ" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="mO1Xkt1Tc0eGMWu9ZWw8yw" name="Mass transfer rate (intestine to mucosa plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_forTwoPores.PARAM_MassTransferIntestineToMucosaPlasma" isDefault="1" displayUnit="µmol/min">
+              <Parameter id="o9mGNdFTOEGX6VXR9TGIZg" name="Mass transfer rate (intestine to mucosa plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_forTwoPores.PARAM_MassTransferIntestineToMucosaPlasma" isDefault="1" displayUnit="µmol/min">
                 <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                 <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
               </Parameter>
@@ -18768,14 +18374,14 @@
           </Container>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="ieDURvTq20a9Vh9mNs-0GQ" name="LargeIntestine_bc_ColonTransversum_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="xofy4H6l4UCl3lNTFfLakA" secondNeighbor="4px34OREBESTH634hwSRsQ">
+      <NeighborhoodBuilder id="U6eVpC_r1kyuLQTUTb5AYw" name="SmallIntestine_bc_UpperIleum_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="vXL46mJIE0uG18PXFjzX5g" secondNeighbor="IziOa_FtaUqUAIU572OpQA">
         <Tags>
           <Tag value="Neighborhood: BloodCells / BloodCells" />
         </Tags>
         <Children>
-          <Container id="gcXu3Wwf_k20RAWflRLdtg" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="tbh6ug9_n0OVWakVCfd9Dg" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="aaUcvcaAY0qMmDNo-SJQ2g" name="Mass transfer rate (intestine to mucosa blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_forTwoPores.PARAM_MassTransferIntestineToMucosaBloodCells" isDefault="1" displayUnit="µmol/min">
+              <Parameter id="hupnmBFKmkSj7FSOGGtsfw" name="Mass transfer rate (intestine to mucosa blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_forTwoPores.PARAM_MassTransferIntestineToMucosaBloodCells" isDefault="1" displayUnit="µmol/min">
                 <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                 <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
               </Parameter>
@@ -18783,44 +18389,132 @@
           </Container>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="PkY7-JHzAESqHY4mSOagHw" name="LargeIntestine_pls_ColonTransversum_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="G9LknYNSJ0CqRovE2-2YJg" secondNeighbor="1FuSD0o0hEa4L3rGx4i7HA">
+      <NeighborhoodBuilder id="bmAu26ytPkiMemSDBMIj-A" name="Lumen_lil_LowerIleum_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="C_Q1ZtRcwUSAmwuymmvd1A" secondNeighbor="ZxmY6nNSm0GN9qpb4qkq_w">
         <Tags>
-          <Tag value="Neighborhood: Plasma / Plasma" />
+          <Tag value="Neighborhood: LowerIleum / Plasma" />
         </Tags>
         <Children>
-          <Container id="y3IOE4FC6Ui9XKp2BJU73w" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="3jahdOzhmEWuHrw1yimFGw" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="nLvMPyk010Gm86TTDPp2BQ" name="Mass transfer rate (intestine to mucosa plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_forTwoPores.PARAM_MassTransferIntestineToMucosaPlasma" isDefault="1" displayUnit="µmol/min">
-                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+              <Parameter id="pvMB_h3UI0uGujjri9VqWA" name="Drug absorption rate (lumen to mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_DrugAbsorption_para" isDefault="1" displayUnit="µmol/min">
                 <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
               </Parameter>
+              <Parameter id="ZuhgasPT1k-AdIceTQiZDQ" name="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" isDefault="1" displayUnit="µmol/min">
+                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
+              <Parameter id="TJzLHcJI8EifXb-Jd8_32Q" name="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" isDefault="1" displayUnit="µmol/min">
+                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
             </Children>
           </Container>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="gslUcvTWRkuXYzzDDOD1Yw" name="LargeIntestine_pls_ColonAscendens_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="G9LknYNSJ0CqRovE2-2YJg" secondNeighbor="m5wMdFXfeU2GNaT-cMXNww">
+      <NeighborhoodBuilder id="YH11GndFkkSy1DRJOq1ztQ" name="Lumen_lil_LowerIleum_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="C_Q1ZtRcwUSAmwuymmvd1A" secondNeighbor="hlUQz3rRx0mOPW0NjWkgEA">
         <Tags>
-          <Tag value="Neighborhood: Plasma / Plasma" />
+          <Tag value="Neighborhood: LowerIleum / Intracellular" />
         </Tags>
         <Children>
-          <Container id="2YZJUo_CGEexMHbDi6SLgw" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="M4C5PVMyJ0ireQ2zJi7F4A" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="KoVoUUzFyEO2bzNceOE47g" name="Mass transfer rate (intestine to mucosa plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_forTwoPores.PARAM_MassTransferIntestineToMucosaPlasma" isDefault="1" displayUnit="µmol/min">
-                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+              <Parameter id="IQgoCz8EAUWXxHfkzsBY7g" name="Drug absorption rate (lumen to mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_DrugAbsorption_trans" isDefault="1" displayUnit="µmol/min">
                 <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
               </Parameter>
-            </Children>
-          </Container>
-        </Children>
-      </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="_Ybq5qvInUKjrZl_q6rrLg" name="LargeIntestine_pls_Caecum_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="G9LknYNSJ0CqRovE2-2YJg" secondNeighbor="PdIK1tifAUOH4joR3xeI0A">
-        <Tags>
+              <Parameter id="cMGWF5wrjE-31XrkAyEXnQ" name="P_int_trans_cell_lum_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_cell_lum_factor" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="UxodTC90U0yWnyZNz79zcg" name="P_int_trans_lum_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_lum_cell_factor" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="_G8Cp2EtqEmuRlnqFKoNOQ" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_K_cell_pls_LowerIleum" isDefault="1">
+                <Info min="0" flag="36" seq="1" ref="0" bb="2" group="67" />
+              </Parameter>
+              <Parameter id="6E0E8ezO5k68zUHFnLhXsg" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_LowerIleum" isDefault="1">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+              </Parameter>
+              <Parameter id="Y7cPSbTbLUm7SyP3ytkq3w" name="pKa_pH_WS_cell_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F1" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="oyHqiJlmGUCPfkqna-r0dQ" name="pKa_pH_WS_cell_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F2" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="63Lgw-UsjEe1vS0HuWLBTA" name="pKa_pH_WS_cell_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F3" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="rLQcQvSVf0K2218LePxf0A" name="pKa_pH_WS_cell_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K1" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="vRhRrrjMmkyJePcAoCUZBw" name="pKa_pH_WS_cell_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K2" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="-6nUUhJBl0ihzOFW2dVQeg" name="pKa_pH_WS_cell_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K3" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="y-_1m_vq-0-kxAwHe3SjqA" name="pKa_pH_WS_cell_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K4" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="nml-Bqeg1EK-y4B3QEhVjA" name="pKa_pH_WS_cell_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K5" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="PpxejvJMrESzfEirvIqaqg" name="pKa_pH_WS_cell_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K6" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="ANq8Suf6REeAmPL6EZvKwQ" name="pKa_pH_WS_cell_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K7" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="xfM9sUv21kOior4mOYeOXQ" name="pKa_pH_WS_cell_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K8" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="xsfyrXqe3E2wXCrgk0wVtQ" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F1" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="Vk0KH9-CA0-Owf8UuvXE1Q" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F2" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="xQtIv5Lp3kWiFLNNIQ-D7g" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F3" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="0h6daChuQkuv5dJ-Ce9wCg" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K1" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="-6q9KUrSxUOKmLYOSX9qjw" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K2" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="CSDLrZSFJkqMaBLb9Uq1sw" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K3" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="Bm4RSMk5k0yVG3c2wGidfw" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K4" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="86iGEP8uTky2sJAu3f1v8g" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K5" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="O52hlzd9306tE3yl3ZPwRw" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K6" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="D7TfxM12JUKlwXDzDNunNA" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K7" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="xW8rFa3Yh0urEiSIjPr6jg" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K8" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="_4LEQ08Vpk6GUKRGwbunCw" name="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" isDefault="1" displayUnit="µmol/min">
+                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
+              <Parameter id="82IAujF53U6P6MNaqZJnaQ" name="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" isDefault="1" displayUnit="µmol/min">
+                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
+            </Children>
+          </Container>
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="Q07iRjjLEEq5_t0UBCUBLg" name="SmallIntestine_pls_LowerIleum_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="Bswuw2JsQ0muIVZwkoC_bA" secondNeighbor="ZxmY6nNSm0GN9qpb4qkq_w">
+        <Tags>
           <Tag value="Neighborhood: Plasma / Plasma" />
         </Tags>
         <Children>
-          <Container id="Qe39KW1V7Uya5C5CNw1stw" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="Y06UlcT8d0KbbG1mUOvz_A" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="y-ZlkpCuhU2EoaDCt207-g" name="Mass transfer rate (intestine to mucosa plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_forTwoPores.PARAM_MassTransferIntestineToMucosaPlasma" isDefault="1" displayUnit="µmol/min">
+              <Parameter id="driEmTIUfkiGA7SHv5JwxQ" name="Mass transfer rate (intestine to mucosa plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_forTwoPores.PARAM_MassTransferIntestineToMucosaPlasma" isDefault="1" displayUnit="µmol/min">
                 <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                 <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
               </Parameter>
@@ -18828,14 +18522,14 @@
           </Container>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="HBGoAIcWcUaVGXkw-501dw" name="LargeIntestine_bc_Caecum_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="xofy4H6l4UCl3lNTFfLakA" secondNeighbor="fCaKlcvkm0ixv3OVTSvUEA">
+      <NeighborhoodBuilder id="cNCzlbdYDEqbUGDuN65_oQ" name="SmallIntestine_bc_LowerIleum_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="vXL46mJIE0uG18PXFjzX5g" secondNeighbor="qqf54SjWUE2QJPKX23ms4g">
         <Tags>
           <Tag value="Neighborhood: BloodCells / BloodCells" />
         </Tags>
         <Children>
-          <Container id="A5XQLv2f7kml5njg96EIKg" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="cxdQIsCOpU-IQJrnakbfuQ" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="OCBKnKHzp0iAHTJDhuiGkw" name="Mass transfer rate (intestine to mucosa blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_forTwoPores.PARAM_MassTransferIntestineToMucosaBloodCells" isDefault="1" displayUnit="µmol/min">
+              <Parameter id="lZLSz3WBuE64aNlCJX47zQ" name="Mass transfer rate (intestine to mucosa blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_forTwoPores.PARAM_MassTransferIntestineToMucosaBloodCells" isDefault="1" displayUnit="µmol/min">
                 <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                 <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
               </Parameter>
@@ -18843,448 +18537,764 @@
           </Container>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="c92dqCrxz0uO5XMLWc_OJg" name="Gallbladder_Lumen_duo" mode="Logical" containerType="Neighborhood" firstNeighbor="Yh8dNoILSE--3hDtmrZ9eQ" secondNeighbor="Soy8bWRBA0aKD_xjTO8QdQ">
-        <Tags>
-          <Tag value="Neighborhood: Gallbladder / Duodenum" />
-        </Tags>
-        <Children>
-          <Container id="08LJjvOfE0OxYCzdmtlLtw" name="MoleculeProperties" mode="Logical" containerType="Other" />
-        </Children>
-      </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="KpLMya9IuEOC9aSKj3rPSQ" name="Liver_pls_Liver_end" mode="Logical" containerType="Neighborhood" firstNeighbor="n-Mf71iFs0a8ZdJwFks7Sw" secondNeighbor="zfM0AeAi4E-FLsNL4mYfPQ">
-        <Tags>
-          <Tag value="Neighborhood: Plasma / Endosome" />
-        </Tags>
-        <Children>
-          <Container id="ch_A4ytu8kqvFCaUTp6GKA" name="MoleculeProperties" mode="Logical" containerType="Other" />
-        </Children>
-      </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="7qhl_IW5nk-3Nge0dv5xkg" name="Liver_end_Liver_int" mode="Logical" containerType="Neighborhood" firstNeighbor="zfM0AeAi4E-FLsNL4mYfPQ" secondNeighbor="o_Lcem1z20etqh8Xprm8iw">
+      <NeighborhoodBuilder id="GOO5YabHxk2t0zGkiznmsA" name="LowerIleum_pls_PortalVein_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="ZxmY6nNSm0GN9qpb4qkq_w" secondNeighbor="d626iVqs-ESin5Db2bAqWg">
         <Tags>
-          <Tag value="Neighborhood: Endosome / Interstitial" />
+          <Tag value="Neighborhood: Plasma / Plasma" />
         </Tags>
         <Children>
-          <Container id="DWloeSq600Ky000pRlQJuw" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="hqyR2az0OEikkFrwoS80CQ" name="MoleculeProperties" mode="Logical" containerType="Other">
+            <Children>
+              <Parameter id="WAe3Em9T9kmkOEVWmUb1rw" name="Mass transfer rate (mucosa to portal vein plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_forTwoPores.PARAM_MassTransferMucosaToPvePlasma" isDefault="1" displayUnit="µmol/min">
+                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+              </Parameter>
+            </Children>
+          </Container>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="jHpAbGcMJUqmnDLg-0v3hw" name="Liver_pls_Liver_int" mode="Logical" containerType="Neighborhood" firstNeighbor="n-Mf71iFs0a8ZdJwFks7Sw" secondNeighbor="o_Lcem1z20etqh8Xprm8iw">
+      <NeighborhoodBuilder id="HHqP18hilEWhpF1peZQ9iQ" name="LowerIleum_bc_PortalVein_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="qqf54SjWUE2QJPKX23ms4g" secondNeighbor="J7qhrNHWA0i3ePh_JHm2LQ">
         <Tags>
-          <Tag value="Neighborhood: Plasma / Interstitial" />
+          <Tag value="Neighborhood: BloodCells / BloodCells" />
         </Tags>
         <Children>
-          <Container id="uFNNIRChc0auu5fiPaHwCg" name="MoleculeProperties" mode="Logical" containerType="Other" />
-          <Parameter id="1eXOQteQO0ukd8GcB-_QwQ" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" isDefault="1" displayUnit="cm²">
-            <Tags>
-              <Tag value="Neighborhood: Plasma / Interstitial" />
-            </Tags>
-            <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-            <Info min="0" flag="122" seq="8" ref="0" bb="32" group="106" />
-          </Parameter>
+          <Container id="vNKOCy7E_EqmQ3VCevtPqg" name="MoleculeProperties" mode="Logical" containerType="Other">
+            <Children>
+              <Parameter id="dvyQ_ehhCkmxTtpjnRGoWw" name="Mass transfer rate (mucosa to portal vein blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_forTwoPores.PARAM_MassTransferMucosaToPveBloodCells" isDefault="1" displayUnit="µmol/min">
+                <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+              </Parameter>
+            </Children>
+          </Container>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="SVqiPjoi-kGIglqb9GgGcw" name="Liver_pls_Liver_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="n-Mf71iFs0a8ZdJwFks7Sw" secondNeighbor="ArBoBqehqUKVujYhz1E5xA">
+      <NeighborhoodBuilder id="3I7OaXbqNUe1zZ6K95VsHQ" name="LargeIntestine_bc_PortalVein_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="ndxtR_Omb0-tlAGFCBQMeg" secondNeighbor="J7qhrNHWA0i3ePh_JHm2LQ">
         <Tags>
-          <Tag value="Neighborhood: Plasma / BloodCells" />
+          <Tag value="Neighborhood: BloodCells / BloodCells" />
         </Tags>
         <Children>
-          <Container id="U2TH_ns1X0ODetoiVC3T6g" name="MoleculeProperties" mode="Logical" containerType="Other" />
-          <Parameter id="U9I1z7YVNkO1mIlzqUkYiQ" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" isDefault="1" displayUnit="cm²">
-            <Tags>
-              <Tag value="Neighborhood: Plasma / BloodCells" />
-            </Tags>
-            <Info min="0" flag="122" seq="10" ref="0" bb="32" group="104" />
-          </Parameter>
+          <Container id="rAEalmO-8EmyduLz0vAytw" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="zweibDQek0u1j8Sn6_wnoA" name="Liver_int_Liver_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="o_Lcem1z20etqh8Xprm8iw" secondNeighbor="R3ZqTlHFT0aa34rtqKRofA">
+      <NeighborhoodBuilder id="0pZUD0DjqUWiRZrDu7LpzA" name="LargeIntestine_end_LargeIntestine_ecl" mode="Logical" containerType="Neighborhood" firstNeighbor="DFKvpifRQUGqQ9iXjr-W9Q" secondNeighbor="0MjJnhA0s063jmqn9J-j4Q">
         <Tags>
-          <Tag value="Neighborhood: Interstitial / Intracellular" />
+          <Tag value="Large intestine  neighborhood" />
+          <Tag value="Neighborhood: Endosome / EndosomalClearance" />
         </Tags>
         <Children>
-          <Container id="utZiA9uLWkyHgNEnoEGYlw" name="MoleculeProperties" mode="Logical" containerType="Other" />
-          <Parameter id="lt9jIMAI8028Cc1YGAd75g" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_liv" isDefault="1" displayUnit="cm²">
-            <Tags>
-              <Tag value="Neighborhood: Interstitial / Intracellular" />
-            </Tags>
-            <Info min="0" flag="122" seq="8" ref="0" bb="32" group="105" />
-          </Parameter>
+          <Container id="9CCR--BWhEytXG_ccBKy7w" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="4dXaDHvbp0yRzoew4CfZdg" name="Periportal_end_Periportal_int" mode="Logical" containerType="Neighborhood" firstNeighbor="2bh0nZ_Y6UOntag5Sp5jGQ" secondNeighbor="HwPP9PlFDUq73CZ_tp_ycQ">
+      <NeighborhoodBuilder id="yEHg2vafg0-fuWMW-qY5sQ" name="LargeIntestine_end_LargeIntestine_int" mode="Logical" containerType="Neighborhood" firstNeighbor="DFKvpifRQUGqQ9iXjr-W9Q" secondNeighbor="xUWR1AMz502IxVmpUhFqYw">
         <Tags>
+          <Tag value="Large intestine  neighborhood" />
           <Tag value="Neighborhood: Endosome / Interstitial" />
         </Tags>
         <Children>
-          <Container id="XboK0ZgFUEaEm8973jkdJg" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="l4zQnG7CQ0-XTQ-csipJbw" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="2qfAKY_vPk-nvQnForRgsw" name="Periportal_int_Periportal_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="HwPP9PlFDUq73CZ_tp_ycQ" secondNeighbor="q9Zn8MoV4k-G3DNkmUKaPw">
+      <NeighborhoodBuilder id="XUEbK7P1DU2KXGdMiJhNMA" name="LargeIntestine_int_LargeIntestine_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="xUWR1AMz502IxVmpUhFqYw" secondNeighbor="jvPCQwh_-UahkbeugzzqCA">
         <Tags>
+          <Tag value="Large intestine  neighborhood" />
           <Tag value="Neighborhood: Interstitial / Intracellular" />
         </Tags>
         <Children>
-          <Container id="-x1BrJiYyUmU3kWtlu6GYg" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="rXMSPuEvNUCQvxzzSUcJbQ" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="b_dtZMay50OgSEXL43TeWg" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+              <Parameter id="lWzU_71hXkSOumk2Dy0qFQ" name="P (interstitial-&gt;intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" isDefault="1" displayUnit="cm/min">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="78" />
               </Parameter>
-              <Parameter id="3KLmtfqOKECOaZvA1lQPEg" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="69" />
+              <Parameter id="zOKHHb5XgUq8_RTUgyfnUg" name="P (intracellular-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" isDefault="1" displayUnit="cm/min">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="76" />
               </Parameter>
-              <Parameter id="k07i4Nac-UWtRIkJam91vA" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
+              <Parameter id="nPJJPR7N4k6aZSAnP809FA" name="P*SA interstitial -&gt; intracellular" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" isDefault="1" displayUnit="l/min">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="1zRqEQXXd0uL1f0BlgbBhA" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
+              <Parameter id="x0Ol_3FNt0OAUShQQ_8fWA" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="xPXetaS1UkCWqMCQ8TUy_A" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
+              <Parameter id="hptkjESjbk-QSfzlJPvgOg" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="-lbm0ttFnkCXRFOm7qZ4fg" name="P*SA interstitial -&gt; intracellular" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" isDefault="1" displayUnit="l/min">
+              <Parameter id="HaFgJKQZjEKcxzW5zTnG7Q" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="JTt986IY_kKlLd5V23yDcg" name="P (intracellular-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" isDefault="1" displayUnit="cm/min">
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="76" />
+              <Parameter id="75Xizq0_Mk67eB15kaGc5w" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="69" />
               </Parameter>
-              <Parameter id="blFOFTQnzEiP-8xu8opb8g" name="P (interstitial-&gt;intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" isDefault="1" displayUnit="cm/min">
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="78" />
+              <Parameter id="OKa6jGkv0kOpvRpd3LGoyw" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
               </Parameter>
             </Children>
           </Container>
-          <Parameter id="2N-uqAoUmEe_se-Sx_i5Bw" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_periportal" isDefault="1" displayUnit="cm²">
+          <Parameter id="b0emeagN0Uu0-OPvBPeFWQ" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_lin" isDefault="1" displayUnit="cm²">
             <Tags>
+              <Tag value="Large intestine  neighborhood" />
               <Tag value="Neighborhood: Interstitial / Intracellular" />
             </Tags>
-            <Info min="0" flag="62" seq="9" ref="0" bb="32" group="105" />
+            <Info min="0" flag="122" seq="7" ref="0" bb="32" group="105" />
           </Parameter>
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       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="jBSjFMhDw0uSMfvR4NeaSw" name="Periportal_pls_Periportal_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="8DZXItaWrkqNKYuUKQ9tjQ" secondNeighbor="c0pnnkb11EiaOMW4lLDk1A">
+      <NeighborhoodBuilder id="XzaCgQQ-tUWsEWPKXOq15g" name="LargeIntestine_int_VenousBlood_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="xUWR1AMz502IxVmpUhFqYw" secondNeighbor="JxP9aCWtgUGhXH_R7w1Z2Q">
+        <Tags>
+          <Tag value="Neighborhood: Interstitial / Plasma" />
+        </Tags>
+        <Children>
+          <Container id="_rS6RIDAhkqJUnhksbkPGA" name="MoleculeProperties" mode="Logical" containerType="Other" />
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="UfmY2wNftU6LELKWRuzSgA" name="LargeIntestine_pls_LargeIntestine_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="RNkPLFnn1Eepynm3sVKH1g" secondNeighbor="ndxtR_Omb0-tlAGFCBQMeg">
         <Tags>
+          <Tag value="Large intestine  neighborhood" />
           <Tag value="Neighborhood: Plasma / BloodCells" />
         </Tags>
         <Children>
-          <Container id="U4Uq4XZk00y_nbA3a8mCFw" name="MoleculeProperties" mode="Logical" containerType="Other" />
-          <Parameter id="fJn-EbiBdEWd2yPPPM66Xw" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_pls_bc_periportal" isDefault="1" displayUnit="cm²">
+          <Container id="yA3PSRu79EyLhU4EsKDCbA" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Parameter id="gQOpg3hXokuoSSATqijkwA" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls_sinlin" isDefault="1" displayUnit="cm²">
             <Tags>
+              <Tag value="Large intestine  neighborhood" />
               <Tag value="Neighborhood: Plasma / BloodCells" />
             </Tags>
-            <Info min="0" flag="62" seq="11" ref="0" bb="32" group="104" />
+            <Info min="0" flag="122" seq="9" ref="0" bb="32" group="104" />
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       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="gHZ3oZosWk2nFxwCfLcoUQ" name="Periportal_pls_Periportal_end" mode="Logical" containerType="Neighborhood" firstNeighbor="8DZXItaWrkqNKYuUKQ9tjQ" secondNeighbor="2bh0nZ_Y6UOntag5Sp5jGQ">
+      <NeighborhoodBuilder id="LdJ_8roX3ESeXW0I6mn_CQ" name="LargeIntestine_pls_LargeIntestine_end" mode="Logical" containerType="Neighborhood" firstNeighbor="RNkPLFnn1Eepynm3sVKH1g" secondNeighbor="DFKvpifRQUGqQ9iXjr-W9Q">
         <Tags>
+          <Tag value="Large intestine  neighborhood" />
           <Tag value="Neighborhood: Plasma / Endosome" />
         </Tags>
         <Children>
-          <Container id="RQAQCoRIlE-JKrGkgKlEQA" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="rphLD8R_RkiFnSYmOLyh4g" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="szK25JDLHUGUSuU_tscy2g" name="Periportal_pls_Periportal_int" mode="Logical" containerType="Neighborhood" firstNeighbor="8DZXItaWrkqNKYuUKQ9tjQ" secondNeighbor="HwPP9PlFDUq73CZ_tp_ycQ">
+      <NeighborhoodBuilder id="JWqOaUEJzkS74LmMS53E9g" name="LargeIntestine_pls_LargeIntestine_int" mode="Logical" containerType="Neighborhood" firstNeighbor="RNkPLFnn1Eepynm3sVKH1g" secondNeighbor="xUWR1AMz502IxVmpUhFqYw">
         <Tags>
+          <Tag value="Large intestine  neighborhood" />
           <Tag value="Neighborhood: Plasma / Interstitial" />
         </Tags>
         <Children>
-          <Container id="UGO7r0m_-06TOqipuDIwUA" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="ypIm3rSnb0WuI1JMVqE3YQ" name="MoleculeProperties" mode="Logical" containerType="Other">
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+      <NeighborhoodBuilder id="rYh232cpkkaYV5Hw6xqi1Q" name="Lung_bc_ArterialBlood_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="nHn8QNvAq0SNQaYeoYdZgA" secondNeighbor="IhEBMJxutUm85iXU4_r5iQ">
         <Tags>
-          <Tag value="Neighborhood: Plasma / BloodCells" />
+          <Tag value="Neighborhood: BloodCells / BloodCells" />
         </Tags>
         <Children>
-          <Container id="qSEH3Y_j10eOWRZzHJARFg" name="MoleculeProperties" mode="Logical" containerType="Other" />
-          <Parameter id="c_BAWuEQvU-JS8f81doWIg" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" isDefault="1" displayUnit="cm²">
-            <Tags>
-              <Tag value="Neighborhood: Plasma / BloodCells" />
-            </Tags>
-            <Info min="0" flag="122" seq="13" ref="0" bb="32" group="104" />
-          </Parameter>
+          <Container id="74aLulJ7w0iEpbSOXKwu0Q" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="RYFIqhFkVEGCnggK9WFAew" name="Lung_int_VenousBlood_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="lQsRSgBhSkaAZAbYMuy3aw" secondNeighbor="lg3JPjAHSUaKoE7vwc_rTw">
+      <NeighborhoodBuilder id="6S8ZKCWbVU-1C1bNEdbrDg" name="Lung_end_Lung_ecl" mode="Logical" containerType="Neighborhood" firstNeighbor="6sArPO4cRU2NlXDyLFMl7w" secondNeighbor="0MjJnhA0s063jmqn9J-j4Q">
         <Tags>
-          <Tag value="Neighborhood: Interstitial / Plasma" />
+          <Tag value="Neighborhood: Endosome / EndosomalClearance" />
+        </Tags>
+        <Children>
+          <Container id="vAvAHEJkA0eypXykYL25Rg" name="MoleculeProperties" mode="Logical" containerType="Other" />
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="pJAX6orOykG7UjflI_Uitg" name="Lung_end_Lung_int" mode="Logical" containerType="Neighborhood" firstNeighbor="6sArPO4cRU2NlXDyLFMl7w" secondNeighbor="Zkd7GZ4iMky8hXd7vc04GQ">
+        <Tags>
+          <Tag value="Neighborhood: Endosome / Interstitial" />
         </Tags>
         <Children>
-          <Container id="OELXbEv7rEqy716qKS3RUg" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="LD0cuMdbzESDtt-rKBAUFg" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="83EuL90Ogkaqk27GDlUNrQ" name="Lung_int_Lung_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="lQsRSgBhSkaAZAbYMuy3aw" secondNeighbor="B1I11L5ugUiDjzdr9Xcdjw">
+      <NeighborhoodBuilder id="8W_SHw7qfEeglqNuUDBauQ" name="Lung_int_Lung_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="Zkd7GZ4iMky8hXd7vc04GQ" secondNeighbor="voNmUWz5pUmSLpJ6_qjfBA">
         <Tags>
           <Tag value="Neighborhood: Interstitial / Intracellular" />
         </Tags>
         <Children>
-          <Container id="r6g8u31bgEuQWU0n6wSDEg" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="_jc1X0UTKUuTEPtnltfwSQ" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="6To70vHop0q_Ij-ryp7Etg" name="P (interstitial-&gt;intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" isDefault="1" displayUnit="cm/min">
+              <Parameter id="k3L5socYp0GlFJjKTJyo_Q" name="P (interstitial-&gt;intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" isDefault="1" displayUnit="cm/min">
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="78" />
               </Parameter>
-              <Parameter id="3LrhjCQK_Uu6VY-KTfch_Q" name="P (intracellular-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" isDefault="1" displayUnit="cm/min">
+              <Parameter id="c82xFAzL30ivfsUapT-MMQ" name="P (intracellular-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" isDefault="1" displayUnit="cm/min">
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="76" />
               </Parameter>
-              <Parameter id="0898X6DULkmsGGPG9ZiX2A" name="P*SA interstitial -&gt; intracellular" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" isDefault="1" displayUnit="l/min">
+              <Parameter id="u3_aaWglukOYHqXt0GEXSA" name="P*SA interstitial -&gt; intracellular" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" isDefault="1" displayUnit="l/min">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="oymTc8rqjkizL8QEdsXPHg" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
+              <Parameter id="xUUFVD2P6EO7NMvwMI_amw" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="Ocgiq8J5AUCSFU_zoxLETw" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
+              <Parameter id="sIaHLq2O6kOFBIrBN4TqVQ" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="z_GtTkMmOECVyrDX2DY4Xg" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
+              <Parameter id="CPMrsTXc10qwislNpLTXhw" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="ja0Z6G2r3kqAueHufS0mtw" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
+              <Parameter id="KTxkpLv_1EmUEy3XbbgTtg" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="69" />
               </Parameter>
-              <Parameter id="EivPuIGBeESRbunZHtEW7w" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
+              <Parameter id="oUrRF6qCEkWXdpUVfWlw4g" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
               </Parameter>
             </Children>
           </Container>
-          <Parameter id="YbpwCwlbJUCYUwVD99mDWA" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_lng" isDefault="1" displayUnit="cm²">
+          <Parameter id="yrK3m0W7s02lVMEzjieVFw" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_lng" isDefault="1" displayUnit="cm²">
             <Tags>
               <Tag value="Neighborhood: Interstitial / Intracellular" />
             </Tags>
@@ -19292,134 +19302,159 @@
           </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="fS5Qf472e0yobcfNhI6qUA" name="Lung_end_Lung_int" mode="Logical" containerType="Neighborhood" firstNeighbor="m5ypZNiFHU6dqZ_Z8BsG6w" secondNeighbor="lQsRSgBhSkaAZAbYMuy3aw">
+      <NeighborhoodBuilder id="KvnjxLR3yUOLF9Y_JI3XGQ" name="Lung_int_VenousBlood_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="Zkd7GZ4iMky8hXd7vc04GQ" secondNeighbor="JxP9aCWtgUGhXH_R7w1Z2Q">
         <Tags>
-          <Tag value="Neighborhood: Endosome / Interstitial" />
+          <Tag value="Neighborhood: Interstitial / Plasma" />
         </Tags>
         <Children>
-          <Container id="fW_NlamlHkiLEbsXPzZeLQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="633-354U70GF7aKtzSR2eQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="pFSmjoK4N0CBV0VFI4KzYg" name="Lung_end_Lung_ecl" mode="Logical" containerType="Neighborhood" firstNeighbor="m5ypZNiFHU6dqZ_Z8BsG6w" secondNeighbor="eDJJFajIZ0qqc5SSL9V05w">
+      <NeighborhoodBuilder id="mttT9_lPRUOgLyVvsB_D0g" name="Lung_pls_ArterialBlood_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="t6OBxd-hCkCODe51LaKiww" secondNeighbor="8w_HEBIvlUCHJDlw_MvzWw">
         <Tags>
-          <Tag value="Neighborhood: Endosome / EndosomalClearance" />
+          <Tag value="Neighborhood: Plasma / Plasma" />
         </Tags>
         <Children>
-          <Container id="hRwLltDSH0if6iyZpy4m-Q" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="n1gkCfN0ZkWhzuUNV_AwSA" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="bQZdCnRCpE-EA_T5AUBQZg" name="Lung_bc_ArterialBlood_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="zsldzYW4pk-M1HRwOQZvjA" secondNeighbor="b_JwGFelbkeRco3dQKg62Q">
+      <NeighborhoodBuilder id="pwE6tVmPFkSnwRYdSQQrnw" name="Lung_pls_Lung_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="t6OBxd-hCkCODe51LaKiww" secondNeighbor="nHn8QNvAq0SNQaYeoYdZgA">
         <Tags>
-          <Tag value="Neighborhood: BloodCells / BloodCells" />
+          <Tag value="Neighborhood: Plasma / BloodCells" />
         </Tags>
         <Children>
-          <Container id="Uih9xn6NKUa-e_Yu6eNrYw" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="cQ4DHWS3oUGUJ7e16sQSKA" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Parameter id="oj3LojCbwE6XaZZ1_8vrjg" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" isDefault="1" displayUnit="cm²">
+            <Tags>
+              <Tag value="Neighborhood: Plasma / BloodCells" />
+            </Tags>
+            <Info min="0" flag="122" seq="13" ref="0" bb="32" group="104" />
+          </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="o4QTl1ZKPE-WmGIy2ACw9w" name="Lung_pls_Lung_end" mode="Logical" containerType="Neighborhood" firstNeighbor="4kCl377ujkOzqrUFkOXeCg" secondNeighbor="m5ypZNiFHU6dqZ_Z8BsG6w">
+      <NeighborhoodBuilder id="QA5Av1MqgU-HLKBBU8RHIQ" name="Lung_pls_Lung_end" mode="Logical" containerType="Neighborhood" firstNeighbor="t6OBxd-hCkCODe51LaKiww" secondNeighbor="6sArPO4cRU2NlXDyLFMl7w">
         <Tags>
           <Tag value="Neighborhood: Plasma / Endosome" />
         </Tags>
         <Children>
-          <Container id="XzCGTYTtaUiP6-OdEdjGVA" name="MoleculeProperties" mode="Logical" containerType="Other" />
-        </Children>
-      </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="qmQPceo2ZEC0t6kDLlfihA" name="Muscle_pls_VenousBlood_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="l51KslyykkOxfiw6tYx29Q" secondNeighbor="lg3JPjAHSUaKoE7vwc_rTw">
-        <Tags>
-          <Tag value="Neighborhood: Plasma / Plasma" />
-        </Tags>
-        <Children>
-          <Container id="KWPVfRrhU0SSW5xQtNE8Tw" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="ozHBiO_Grk2dWPYWEq6mHg" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="xiNJYbzb2UeLJkwU4BSwOQ" name="Muscle_int_VenousBlood_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="L6YXDgHPcEOPmoASSlot2w" secondNeighbor="lg3JPjAHSUaKoE7vwc_rTw">
+      <NeighborhoodBuilder id="4-gVrS9zFECZgng8LBl0Xw" name="Lung_pls_Lung_int" mode="Logical" containerType="Neighborhood" firstNeighbor="t6OBxd-hCkCODe51LaKiww" secondNeighbor="Zkd7GZ4iMky8hXd7vc04GQ">
         <Tags>
-          <Tag value="Neighborhood: Interstitial / Plasma" />
+          <Tag value="Neighborhood: Plasma / Interstitial" />
         </Tags>
         <Children>
-          <Container id="LTJQqusHf0ioCtash5NUIg" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="reBfIzSZzk2qdb7dzcl-Vg" name="MoleculeProperties" mode="Logical" containerType="Other">
+            <Children>
+              <Parameter id="z7l4nSDSxUWQUdQvXz5IYA" name="P (large endothelial pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial_l" isDefault="1" displayUnit="cm/min">
+                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="79" />
+              </Parameter>
+              <Parameter id="XXw_DacyH0yDaU-TQ_vA0w" name="P (plasma&lt;-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial" isDefault="1" displayUnit="cm/min">
+                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="77" />
+              </Parameter>
+              <Parameter id="a3sZPD0Nxkqm3ahrwxShEg" name="P (small endothelial pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial_s" isDefault="1" displayUnit="cm/min">
+                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="80" />
+              </Parameter>
+              <Parameter id="I00JOl3ul0ubKm5MA3Y47A" name="Partition coefficient (interstitial/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" isDefault="1">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="70" />
+              </Parameter>
+              <Parameter id="PGXEXorv9EaMfxDStL274A" name="Peclet number (large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CalcPecletNumber.PecletNumber_l" isDefault="1">
+                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="116" />
+              </Parameter>
+              <Parameter id="8_pZ76gyvEmJ2RguX9rXxg" name="Peclet number (small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CalcPecletNumber.PecletNumber_s" isDefault="1">
+                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="116" />
+              </Parameter>
+              <Parameter id="M-bCUHXI7EOZP6nBJwH1Mg" name="Radius ratio (solute/large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_gamma_l" isDefault="1">
+                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="116" />
+              </Parameter>
+              <Parameter id="PbYIYBbey0alA0sxGB4D1w" name="Radius ratio (solute/small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_gamma_s" isDefault="1">
+                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="116" />
+              </Parameter>
+              <Parameter id="uUqodeevfkyWW9BzlMpW2A" name="Reflection coefficient (large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_sigma_l" isDefault="1">
+                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                <Info min="0" flag="58" seq="1" ref="0" bb="2" group="89" />
+              </Parameter>
+              <Parameter id="RsokRqnLv0mQvbwxGQQDAQ" name="Reflection coefficient (small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_sigma_s" isDefault="1">
+                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                <Info min="0" flag="58" seq="1" ref="0" bb="2" group="90" />
+              </Parameter>
+            </Children>
+          </Container>
+          <Parameter id="O4vg1tR9U0eWot8WoHzd9A" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" isDefault="1" displayUnit="cm²">
+            <Tags>
+              <Tag value="Neighborhood: Plasma / Interstitial" />
+            </Tags>
+            <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+            <Info min="0" flag="122" seq="11" ref="0" bb="32" group="106" />
+          </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="vRL9djgK7UWNKSAcUXRvuA" name="Muscle_end_Muscle_int" mode="Logical" containerType="Neighborhood" firstNeighbor="2goE3ZwQykGya60S-lRRDA" secondNeighbor="L6YXDgHPcEOPmoASSlot2w">
+      <NeighborhoodBuilder id="c3ljAwCD0Ey-tducLN9W1w" name="Muscle_bc_VenousBlood_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="kD3oluKAvkyAZrqeM4x7lg" secondNeighbor="s69zFizy-UefsPiLLFllaw">
         <Tags>
-          <Tag value="Neighborhood: Endosome / Interstitial" />
+          <Tag value="Neighborhood: BloodCells / BloodCells" />
         </Tags>
         <Children>
-          <Container id="wa5Yv6WmF0at9NoEMIRMaw" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="5hc8eX_4VkyZIMaORDlqFA" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="tt7FgBUGXkC0qZDfUh65VA" name="Muscle_end_Muscle_ecl" mode="Logical" containerType="Neighborhood" firstNeighbor="2goE3ZwQykGya60S-lRRDA" secondNeighbor="eDJJFajIZ0qqc5SSL9V05w">
+      <NeighborhoodBuilder id="rgZv4ipZ8U6_nM6wJbF1vA" name="Muscle_end_Muscle_ecl" mode="Logical" containerType="Neighborhood" firstNeighbor="nSI2zw8jAUmcoznj3LyflA" secondNeighbor="0MjJnhA0s063jmqn9J-j4Q">
         <Tags>
           <Tag value="Neighborhood: Endosome / EndosomalClearance" />
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-        <Tags>
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-        </Tags>
-        <Children>
-          <Container id="PoOtl2v5YUSpQDgZOPX1ZQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
-          <Parameter id="N6W6eEhuVkiHXP7fQGUyfQ" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" isDefault="1" displayUnit="cm²">
-            <Tags>
-              <Tag value="Neighborhood: Plasma / BloodCells" />
-            </Tags>
-            <Info min="0" flag="122" seq="14" ref="0" bb="32" group="104" />
-          </Parameter>
+          <Container id="rLROp6y3lEiqiD7ZT0paQA" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="4DsbpUv59kuJ3kgz34ns-g" name="Muscle_bc_VenousBlood_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="wB4puu63wEqnvWTKpCUHMQ" secondNeighbor="BvN_npw9ekupr6uHYGaj_g">
+      <NeighborhoodBuilder id="Wiz0VXG3e0aZ15KOL_RujA" name="Muscle_end_Muscle_int" mode="Logical" containerType="Neighborhood" firstNeighbor="nSI2zw8jAUmcoznj3LyflA" secondNeighbor="NoL4umyvkU67TnTPwQxaQg">
         <Tags>
-          <Tag value="Neighborhood: BloodCells / BloodCells" />
+          <Tag value="Neighborhood: Endosome / Interstitial" />
         </Tags>
         <Children>
-          <Container id="W6OLHO2O-U6JoQr5-nNnnw" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="j_CmWCOcj0G7n-QSm8McQQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
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-      <NeighborhoodBuilder id="zM4NkADiXk-k0OkrH89htA" name="Muscle_int_Muscle_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="L6YXDgHPcEOPmoASSlot2w" secondNeighbor="kHsjTwCHjU-nHlu3y7DDGg">
+      <NeighborhoodBuilder id="7gF84IrxKEK2K6nFGxnuaw" name="Muscle_int_Muscle_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="NoL4umyvkU67TnTPwQxaQg" secondNeighbor="YzO-mRTvjkKoEVlD4EVseA">
         <Tags>
           <Tag value="Neighborhood: Interstitial / Intracellular" />
         </Tags>
         <Children>
-          <Container id="KphoII9FYkathN_9l86LYA" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="Gb5PgpFa80igRmQztTIioA" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="tdjvSMGrl0mVoDRf-P4Fkw" name="P*SA interstitial -&gt; intracellular" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" isDefault="1" displayUnit="l/min">
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+              <Parameter id="RZZQEYpnokGxHC3mTTsfCw" name="P (interstitial-&gt;intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" isDefault="1" displayUnit="cm/min">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="78" />
               </Parameter>
-              <Parameter id="wLB4fsfTe0iwOFxgVDuhHg" name="P (intracellular-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" isDefault="1" displayUnit="cm/min">
+              <Parameter id="Y2yCFIIJgkaNiXRSHKEzNw" name="P (intracellular-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" isDefault="1" displayUnit="cm/min">
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="76" />
               </Parameter>
-              <Parameter id="2OFM7WRUb0SjVvW6F8wuVg" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
+              <Parameter id="_okpDt1uHEOQhNxhb-9Dyw" name="P*SA interstitial -&gt; intracellular" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" isDefault="1" displayUnit="l/min">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="e08CeHsCZkODbaNvLI0AZw" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="2zYuShMCuUSWZ6U5tZPv5w" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
+              <Parameter id="-KIwBPvkdE6ARMyRLEluBQ" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="bbYsyfhRSEWZbIWJ3m2yyQ" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
+              <Parameter id="n7eq1p6J40mPO35qLd2aGg" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="QIgGoW4BFEG03Z2O8q8HiQ" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
+              <Parameter id="qsfcHlUUfUyqEdtdG_qWMg" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="69" />
               </Parameter>
-              <Parameter id="xSxkZh-_g0edHMBTpe8LCw" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
+              <Parameter id="qTLdpbGvEUCZK8FQ36SjMA" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
               </Parameter>
-              <Parameter id="3f5eGzbX6kKVA757J4MRgg" name="P (interstitial-&gt;intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" isDefault="1" displayUnit="cm/min">
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="78" />
-              </Parameter>
             </Children>
           </Container>
-          <Parameter id="pMLtFxZm3kKvujRmtCq3zg" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mus" isDefault="1" displayUnit="cm²">
+          <Parameter id="3rNK7wdSfkebEY4QfnLa2Q" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mus" isDefault="1" displayUnit="cm²">
             <Tags>
               <Tag value="Neighborhood: Interstitial / Intracellular" />
             </Tags>
@@ -19427,200 +19462,159 @@
           </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="LzEIb499tUSFQBPAmNGlZw" name="Muscle_pls_Muscle_int" mode="Logical" containerType="Neighborhood" firstNeighbor="l51KslyykkOxfiw6tYx29Q" secondNeighbor="L6YXDgHPcEOPmoASSlot2w">
+      <NeighborhoodBuilder id="X0WlJt7LsESuaAnxf2tO-A" name="Muscle_int_VenousBlood_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="NoL4umyvkU67TnTPwQxaQg" secondNeighbor="JxP9aCWtgUGhXH_R7w1Z2Q">
         <Tags>
-          <Tag value="Neighborhood: Plasma / Interstitial" />
+          <Tag value="Neighborhood: Interstitial / Plasma" />
         </Tags>
         <Children>
-          <Container id="Oz1T5Gr0SUKoXoL8ou-UaA" name="MoleculeProperties" mode="Logical" containerType="Other">
-            <Children>
-              <Parameter id="XVUcLJEY70K2sWcJYWQk9A" name="Peclet number (large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CalcPecletNumber.PecletNumber_l" isDefault="1">
-                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
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-              </Parameter>
-              <Parameter id="xTyQsfLn-0CSO8GVJsSmKQ" name="Radius ratio (solute/large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_gamma_l" isDefault="1">
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-                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="116" />
-              </Parameter>
-              <Parameter id="7bjvCs31b0eE40U8gX-O1Q" name="Radius ratio (solute/small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_gamma_s" isDefault="1">
-                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="116" />
-              </Parameter>
-              <Parameter id="m_gNrlOLQkmJtLkUT_L5sg" name="Reflection coefficient (large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_sigma_l" isDefault="1">
-                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-                <Info min="0" flag="58" seq="1" ref="0" bb="2" group="89" />
-              </Parameter>
-              <Parameter id="O9aUW2IGwkKS_4EQ3ubAbA" name="Reflection coefficient (small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_sigma_s" isDefault="1">
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-                <Info min="0" flag="58" seq="1" ref="0" bb="2" group="90" />
-              </Parameter>
-              <Parameter id="OV2L1mRN6kW0Uslr283dhg" name="Partition coefficient (interstitial/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" isDefault="1">
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="70" />
-              </Parameter>
-              <Parameter id="4OwxR-fX0kadKRamlpbNlg" name="Peclet number (small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CalcPecletNumber.PecletNumber_s" isDefault="1">
-                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="116" />
-              </Parameter>
-              <Parameter id="fFGX2ugTVk22wAkA_cQIwg" name="P (large endothelial pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial_l" isDefault="1" displayUnit="cm/min">
-                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="79" />
-              </Parameter>
-              <Parameter id="LFzd0_4Z-0uVGu4sGC2Jjg" name="P (plasma&lt;-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial" isDefault="1" displayUnit="cm/min">
-                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
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-              </Parameter>
-              <Parameter id="TOLcJo1gDUG331t7IiR0cQ" name="P (small endothelial pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial_s" isDefault="1" displayUnit="cm/min">
-                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="80" />
-              </Parameter>
-            </Children>
-          </Container>
-          <Parameter id="QKAHc2kGUk6mPBgR0xjjDg" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" isDefault="1" displayUnit="cm²">
+          <Container id="4N5eUY0D_EK360gWm6YYrA" name="MoleculeProperties" mode="Logical" containerType="Other" />
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="Y5TPT0T-NUSXiLfrkI97Hg" name="Muscle_pls_Muscle_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="J6TvTdzQc0qHhjOUV7HN2A" secondNeighbor="kD3oluKAvkyAZrqeM4x7lg">
+        <Tags>
+          <Tag value="Neighborhood: Plasma / BloodCells" />
+        </Tags>
+        <Children>
+          <Container id="Kayim60yhECshTE7ldn7pw" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Parameter id="UCZkcDGF2EKYG3sF4em7VQ" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" isDefault="1" displayUnit="cm²">
             <Tags>
-              <Tag value="Neighborhood: Plasma / Interstitial" />
+              <Tag value="Neighborhood: Plasma / BloodCells" />
             </Tags>
-            <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-            <Info min="0" flag="122" seq="12" ref="0" bb="32" group="106" />
+            <Info min="0" flag="122" seq="14" ref="0" bb="32" group="104" />
           </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="C94yRVNHUkq2F1qtuc9dWg" name="Pancreas_pls_Pancreas_int" mode="Logical" containerType="Neighborhood" firstNeighbor="EWh-xn7PUUmE9uA8-XEpMw" secondNeighbor="kdNRou-4zEuSIs3n1DWAjw">
+      <NeighborhoodBuilder id="oIZ7G1cPUEGvAo4VgmrZPA" name="Muscle_pls_Muscle_end" mode="Logical" containerType="Neighborhood" firstNeighbor="J6TvTdzQc0qHhjOUV7HN2A" secondNeighbor="nSI2zw8jAUmcoznj3LyflA">
+        <Tags>
+          <Tag value="Neighborhood: Plasma / Endosome" />
+        </Tags>
+        <Children>
+          <Container id="klX_ghUdAU2FyyMotDf0Fg" name="MoleculeProperties" mode="Logical" containerType="Other" />
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="CrX2PEzL20qI-ZPYGUZs-g" name="Muscle_pls_Muscle_int" mode="Logical" containerType="Neighborhood" firstNeighbor="J6TvTdzQc0qHhjOUV7HN2A" secondNeighbor="NoL4umyvkU67TnTPwQxaQg">
         <Tags>
           <Tag value="Neighborhood: Plasma / Interstitial" />
         </Tags>
         <Children>
-          <Container id="K0Yt3g8q5EWSq3sc7SFayw" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="ll2IBkGfn0SKtKp29BBd8Q" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="teAEU448XE-EsbhFIYLRvg" name="Reflection coefficient (small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_sigma_s" isDefault="1">
+              <Parameter id="Q3yHRUocaUusFIOfY01o4Q" name="P (large endothelial pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial_l" isDefault="1" displayUnit="cm/min">
                 <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-                <Info min="0" flag="58" seq="1" ref="0" bb="2" group="90" />
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="79" />
               </Parameter>
-              <Parameter id="_keELJC_P0aTDGV-X5yjgg" name="Radius ratio (solute/small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_gamma_s" isDefault="1">
+              <Parameter id="Pq-z8Eal_kCMMDQSu8QMqw" name="P (plasma&lt;-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial" isDefault="1" displayUnit="cm/min">
                 <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="116" />
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="77" />
               </Parameter>
-              <Parameter id="pBNY-mJiSEyIf8sdVvMNsQ" name="Radius ratio (solute/large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_gamma_l" isDefault="1">
+              <Parameter id="l7NjfnQejU--fehrvPEO7g" name="P (small endothelial pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial_s" isDefault="1" displayUnit="cm/min">
                 <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="116" />
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="80" />
               </Parameter>
-              <Parameter id="9Vqxo5V8w0SEpycgOPVjwA" name="Reflection coefficient (large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_sigma_l" isDefault="1">
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-                <Info min="0" flag="58" seq="1" ref="0" bb="2" group="89" />
+              <Parameter id="2zClitUZUkCYB3M71t819Q" name="Partition coefficient (interstitial/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" isDefault="1">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="70" />
               </Parameter>
-              <Parameter id="GR8y_GqAdkaDD0_WkQ9Y1Q" name="P (large endothelial pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial_l" isDefault="1" displayUnit="cm/min">
+              <Parameter id="2WE9erOohEq_U8YPjs0Whw" name="Peclet number (large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CalcPecletNumber.PecletNumber_l" isDefault="1">
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-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="79" />
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="116" />
               </Parameter>
-              <Parameter id="fHHXBMZ0TU-hQlzZnD8BpQ" name="P (plasma&lt;-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial" isDefault="1" displayUnit="cm/min">
+              <Parameter id="ZGUWjvUKrEew8HfxCdFoKg" name="Peclet number (small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CalcPecletNumber.PecletNumber_s" isDefault="1">
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-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="77" />
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="116" />
               </Parameter>
-              <Parameter id="XBUOijcZGEqjRUSE6DOr2Q" name="P (small endothelial pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial_s" isDefault="1" displayUnit="cm/min">
+              <Parameter id="gKmBHQzF6kCclkp6uLx0Fw" name="Radius ratio (solute/large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_gamma_l" isDefault="1">
                 <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="80" />
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="116" />
               </Parameter>
-              <Parameter id="A3nGZAdTy02tNZ2KA1bN3A" name="Partition coefficient (interstitial/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" isDefault="1">
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="70" />
+              <Parameter id="OaNSne252UqDPbl9GAouLg" name="Radius ratio (solute/small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_gamma_s" isDefault="1">
+                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="116" />
               </Parameter>
-              <Parameter id="4pN3wwFv3EOzHHTt__Tq3w" name="Peclet number (large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CalcPecletNumber.PecletNumber_l" isDefault="1">
+              <Parameter id="z-XQXdmZ2kiO8m1vl8Qvsw" name="Reflection coefficient (large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_sigma_l" isDefault="1">
                 <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="116" />
+                <Info min="0" flag="58" seq="1" ref="0" bb="2" group="89" />
               </Parameter>
-              <Parameter id="szwJwQ34s0WV7beGm08epQ" name="Peclet number (small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CalcPecletNumber.PecletNumber_s" isDefault="1">
+              <Parameter id="sldiETFZJkqJRuV22QikcQ" name="Reflection coefficient (small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_sigma_s" isDefault="1">
                 <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="116" />
+                <Info min="0" flag="58" seq="1" ref="0" bb="2" group="90" />
               </Parameter>
             </Children>
           </Container>
-          <Parameter id="dzyBmKh32kOxyzMCsTVJdQ" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" isDefault="1" displayUnit="cm²">
+          <Parameter id="OeIbXjujBUWu6TT8s7Ma8w" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" isDefault="1" displayUnit="cm²">
             <Tags>
               <Tag value="Neighborhood: Plasma / Interstitial" />
             </Tags>
             <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-            <Info min="0" flag="122" seq="13" ref="0" bb="32" group="106" />
+            <Info min="0" flag="122" seq="12" ref="0" bb="32" group="106" />
           </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="N6Sml9u7FUe3C5BTloNNSQ" name="Pancreas_pls_PortalVein_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="EWh-xn7PUUmE9uA8-XEpMw" secondNeighbor="5TpyW0Sd9USQGXc2frzUgA">
+      <NeighborhoodBuilder id="oaLTrq-t-0eZHiMCxUNrLw" name="Muscle_pls_VenousBlood_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="J6TvTdzQc0qHhjOUV7HN2A" secondNeighbor="JxP9aCWtgUGhXH_R7w1Z2Q">
         <Tags>
           <Tag value="Neighborhood: Plasma / Plasma" />
         </Tags>
         <Children>
-          <Container id="ySyp6apKLkWQTmKaMZWu-g" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="V2ttgEERcky7azPj9avbxw" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="_M5DM7eqO0GbxBp7ZrZ7NA" name="Pancreas_pls_Pancreas_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="EWh-xn7PUUmE9uA8-XEpMw" secondNeighbor="SwaAMmojDE-s6kxDPyIUdw">
+      <NeighborhoodBuilder id="w03frPqyp02-GbrDkTJuOQ" name="Pancreas_bc_PortalVein_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="l1XrGlW2T0imgmV2b6Ugyw" secondNeighbor="J7qhrNHWA0i3ePh_JHm2LQ">
         <Tags>
-          <Tag value="Neighborhood: Plasma / BloodCells" />
-        </Tags>
-        <Children>
-          <Container id="5xsMJZAWKU6Q-cAomDRkWA" name="MoleculeProperties" mode="Logical" containerType="Other" />
-          <Parameter id="h7s1gJgdOEG3CtI5dkNNYQ" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" isDefault="1" displayUnit="cm²">
-            <Tags>
-              <Tag value="Neighborhood: Plasma / BloodCells" />
-            </Tags>
-            <Info min="0" flag="122" seq="15" ref="0" bb="32" group="104" />
-          </Parameter>
-        </Children>
-      </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="odnUQGuWokmfWakTeNN5IA" name="Pancreas_int_VenousBlood_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="kdNRou-4zEuSIs3n1DWAjw" secondNeighbor="lg3JPjAHSUaKoE7vwc_rTw">
-        <Tags>
-          <Tag value="Neighborhood: Interstitial / Plasma" />
+          <Tag value="Neighborhood: BloodCells / BloodCells" />
         </Tags>
         <Children>
-          <Container id="7d9R2oxkoUy63XAViaacqQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="l0dxgtbKQE27URyci0qjSQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="ykSoxKhcLUuMlPBR-Shuig" name="Pancreas_pls_Pancreas_end" mode="Logical" containerType="Neighborhood" firstNeighbor="EWh-xn7PUUmE9uA8-XEpMw" secondNeighbor="NDXdmAE2kkWaPl7eZMsm4A">
+      <NeighborhoodBuilder id="ynHoauxElESXW0cQ8KboBA" name="Pancreas_end_Pancreas_ecl" mode="Logical" containerType="Neighborhood" firstNeighbor="zkGaR8tf5EOO3o_7zyiOzA" secondNeighbor="0MjJnhA0s063jmqn9J-j4Q">
         <Tags>
-          <Tag value="Neighborhood: Plasma / Endosome" />
+          <Tag value="Neighborhood: Endosome / EndosomalClearance" />
         </Tags>
         <Children>
-          <Container id="MpOHml8pEEuPnDRFT3P8zA" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="qW-9nhSbR0-iMXynex611A" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="QLAvELk67EyFWFOgZ6w6mQ" name="Pancreas_end_Pancreas_int" mode="Logical" containerType="Neighborhood" firstNeighbor="NDXdmAE2kkWaPl7eZMsm4A" secondNeighbor="kdNRou-4zEuSIs3n1DWAjw">
+      <NeighborhoodBuilder id="ZYMtyTcTxEeiMh-m6X1hPA" name="Pancreas_end_Pancreas_int" mode="Logical" containerType="Neighborhood" firstNeighbor="zkGaR8tf5EOO3o_7zyiOzA" secondNeighbor="c7Wcz-kb-U6n7s92Ib_57g">
         <Tags>
           <Tag value="Neighborhood: Endosome / Interstitial" />
         </Tags>
         <Children>
-          <Container id="ZmZFHDx8jUeiIlHuzH362g" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="RljctQLvbUqWAOcnXH58hA" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="Nvr8iQGWRE-AkZLMbPmywQ" name="Pancreas_int_Pancreas_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="kdNRou-4zEuSIs3n1DWAjw" secondNeighbor="GxOX79iHqkqnNNKmHgBnGQ">
+      <NeighborhoodBuilder id="3UvgXP842kCvfH_4eIgdrw" name="Pancreas_int_Pancreas_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="c7Wcz-kb-U6n7s92Ib_57g" secondNeighbor="98Vq8ACApEes9oIbIioZTw">
         <Tags>
           <Tag value="Neighborhood: Interstitial / Intracellular" />
         </Tags>
         <Children>
-          <Container id="ZJd-C-NOqk2q1AARVaBQNQ" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="vMycxehJHUusLN3kti6V0w" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="Tj-xoj-rB0WA9ps9yPwxtQ" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
-              </Parameter>
-              <Parameter id="vSdXwb7ZuE6nhtHivTDsZg" name="P (interstitial-&gt;intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" isDefault="1" displayUnit="cm/min">
+              <Parameter id="OdVoB-rcgUqDVO8QbPBnEg" name="P (interstitial-&gt;intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" isDefault="1" displayUnit="cm/min">
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="78" />
               </Parameter>
-              <Parameter id="jE-ghY7nTEqq1a9huY9_Xg" name="P (intracellular-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" isDefault="1" displayUnit="cm/min">
+              <Parameter id="ZsSlhHfq8Uma1t-crVUS_w" name="P (intracellular-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" isDefault="1" displayUnit="cm/min">
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="76" />
               </Parameter>
-              <Parameter id="85vr_CKCXUeRNgckarxMBg" name="P*SA interstitial -&gt; intracellular" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" isDefault="1" displayUnit="l/min">
+              <Parameter id="ZZ82Ydr8MEmjcMP_F-vvxA" name="P*SA interstitial -&gt; intracellular" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" isDefault="1" displayUnit="l/min">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="orfL3P89dEGoMIQ8YDBJmA" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="h8kC5CHBqU2FIzVmDX5GTA" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="JRmK1PEgakGmWcg338Vuww" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
+              <Parameter id="uLIoOFa8E0WjnVz3tA-5_Q" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="5ffkhGnLOkq-bTm88D1Ynw" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
+              <Parameter id="_Yxg2DiYekGeuaSuCHJ6fQ" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="69" />
               </Parameter>
-              <Parameter id="pF1kS6ABt0CyIEsYmqEvLA" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
+              <Parameter id="HzSxxs69QUKF0walUBvRIg" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
               </Parameter>
-              <Parameter id="bhAYhh67JkON_uvAzvbBhw" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
-              </Parameter>
             </Children>
           </Container>
-          <Parameter id="35A8dhVFb0GzUxLejRW7WA" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_pan" isDefault="1" displayUnit="cm²">
+          <Parameter id="Xx4vqe_X-kyXWR8ICFJY2g" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_pan" isDefault="1" displayUnit="cm²">
             <Tags>
               <Tag value="Neighborhood: Interstitial / Intracellular" />
             </Tags>
@@ -19628,177 +19622,256 @@
           </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="4MPFGxfB30K3i7yAXiOmHQ" name="Pancreas_bc_PortalVein_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="SwaAMmojDE-s6kxDPyIUdw" secondNeighbor="oz2_zRPfzk-ZhQqUyIQ6kg">
+      <NeighborhoodBuilder id="NoFynscSOEqnb6byM30Aqg" name="Pancreas_int_VenousBlood_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="c7Wcz-kb-U6n7s92Ib_57g" secondNeighbor="JxP9aCWtgUGhXH_R7w1Z2Q">
         <Tags>
-          <Tag value="Neighborhood: BloodCells / BloodCells" />
+          <Tag value="Neighborhood: Interstitial / Plasma" />
         </Tags>
         <Children>
-          <Container id="YjwYU7Y1F0OZDuDsPOYJJw" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="4UPy5PJdzUeA2cFY1tgJhw" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="3KuFDWdXh0qWg2YeKsf13g" name="Pancreas_end_Pancreas_ecl" mode="Logical" containerType="Neighborhood" firstNeighbor="NDXdmAE2kkWaPl7eZMsm4A" secondNeighbor="eDJJFajIZ0qqc5SSL9V05w">
+      <NeighborhoodBuilder id="SC3KQ5f83EuQz8PEIDwVAQ" name="Pancreas_pls_Pancreas_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="YsbwAOG-BEmsvMbXYCnGFA" secondNeighbor="l1XrGlW2T0imgmV2b6Ugyw">
         <Tags>
-          <Tag value="Neighborhood: Endosome / EndosomalClearance" />
+          <Tag value="Neighborhood: Plasma / BloodCells" />
+        </Tags>
+        <Children>
+          <Container id="oXMu7CCLA028LoLIx1a2dw" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Parameter id="yTLJ2oH1R06hT4b2FYQcXA" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" isDefault="1" displayUnit="cm²">
+            <Tags>
+              <Tag value="Neighborhood: Plasma / BloodCells" />
+            </Tags>
+            <Info min="0" flag="122" seq="15" ref="0" bb="32" group="104" />
+          </Parameter>
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="aQCaaKSLB0uQxMphdrDeFA" name="Pancreas_pls_Pancreas_end" mode="Logical" containerType="Neighborhood" firstNeighbor="YsbwAOG-BEmsvMbXYCnGFA" secondNeighbor="zkGaR8tf5EOO3o_7zyiOzA">
+        <Tags>
+          <Tag value="Neighborhood: Plasma / Endosome" />
         </Tags>
         <Children>
-          <Container id="UfVZMuBuv0Ct6hQs1FcIEA" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="itwtMJCufkC3VfUS-SFU-w" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="KzbENh0IkUm0cP5n0lULTw" name="Rectum_pls_PortalVein_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="Yd0rccV71UKsC54RMkELFQ" secondNeighbor="5TpyW0Sd9USQGXc2frzUgA">
+      <NeighborhoodBuilder id="-S0nP1mkuUezbhaf7jGOtg" name="Pancreas_pls_Pancreas_int" mode="Logical" containerType="Neighborhood" firstNeighbor="YsbwAOG-BEmsvMbXYCnGFA" secondNeighbor="c7Wcz-kb-U6n7s92Ib_57g">
         <Tags>
-          <Tag value="Neighborhood: Plasma / Plasma" />
+          <Tag value="Neighborhood: Plasma / Interstitial" />
         </Tags>
         <Children>
-          <Container id="3cEQHUzJikeSZLUr3MkbrA" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="m6J3eXyQnUGwWa84XKZo1w" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="TOiZ4HWPUUm3e-UfQ80yxw" name="Mass transfer rate (mucosa to portal vein plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_forTwoPores.PARAM_MassTransferMucosaToPvePlasma" isDefault="1" displayUnit="µmol/min">
+              <Parameter id="0fE-DhTrtUaUAnZAjx12SQ" name="P (large endothelial pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial_l" isDefault="1" displayUnit="cm/min">
                 <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="79" />
+              </Parameter>
+              <Parameter id="ymMUaJbqTU6h7MMgubdcEA" name="P (plasma&lt;-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial" isDefault="1" displayUnit="cm/min">
+                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="77" />
+              </Parameter>
+              <Parameter id="mIwYGxlwIk6GbjhHJY2l8A" name="P (small endothelial pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial_s" isDefault="1" displayUnit="cm/min">
+                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="80" />
+              </Parameter>
+              <Parameter id="PTC1BzZhF0q8lfaSzUfVSQ" name="Partition coefficient (interstitial/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" isDefault="1">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="70" />
+              </Parameter>
+              <Parameter id="wqHlBiJCe0iXZtraSNz-dw" name="Peclet number (large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CalcPecletNumber.PecletNumber_l" isDefault="1">
+                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="116" />
+              </Parameter>
+              <Parameter id="ZlVrcIx3pk6l2vHDCmCavA" name="Peclet number (small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CalcPecletNumber.PecletNumber_s" isDefault="1">
+                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="116" />
+              </Parameter>
+              <Parameter id="jQO-hx963ECOMzsWjXFehg" name="Radius ratio (solute/large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_gamma_l" isDefault="1">
+                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="116" />
+              </Parameter>
+              <Parameter id="DBxiwMds4E65xh2ZEkdvhQ" name="Radius ratio (solute/small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_gamma_s" isDefault="1">
+                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="116" />
+              </Parameter>
+              <Parameter id="aR36UP7URkS8LwKAOrWBmQ" name="Reflection coefficient (large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_sigma_l" isDefault="1">
+                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                <Info min="0" flag="58" seq="1" ref="0" bb="2" group="89" />
+              </Parameter>
+              <Parameter id="UyGnhnGWS0C1JTy6TN_Vbw" name="Reflection coefficient (small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_sigma_s" isDefault="1">
+                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                <Info min="0" flag="58" seq="1" ref="0" bb="2" group="90" />
               </Parameter>
             </Children>
           </Container>
+          <Parameter id="sOD373hzlU25a7AE_zzPBw" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" isDefault="1" displayUnit="cm²">
+            <Tags>
+              <Tag value="Neighborhood: Plasma / Interstitial" />
+            </Tags>
+            <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+            <Info min="0" flag="122" seq="13" ref="0" bb="32" group="106" />
+          </Parameter>
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="eBP93pHG_0GuVNM6MzQEWA" name="Pancreas_pls_PortalVein_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="YsbwAOG-BEmsvMbXYCnGFA" secondNeighbor="d626iVqs-ESin5Db2bAqWg">
+        <Tags>
+          <Tag value="Neighborhood: Plasma / Plasma" />
+        </Tags>
+        <Children>
+          <Container id="mcp8gN_4U0ubKG7W6MA__g" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="13rP7r_VKEOmYa71l97KaQ" name="Rectum_bc_PortalVein_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="p0bnHVbUckaxiZF-DyaNeg" secondNeighbor="oz2_zRPfzk-ZhQqUyIQ6kg">
+      <NeighborhoodBuilder id="dZxzux9D1ki0_l15FXSUkQ" name="Lumen_rect_Rectum_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="94Sc5RUGNUaXs_bDJ2T7lQ" secondNeighbor="8f8l-2PnRkC7BevNFjoHJw">
         <Tags>
-          <Tag value="Neighborhood: BloodCells / BloodCells" />
+          <Tag value="Neighborhood: Rectum / Plasma" />
         </Tags>
         <Children>
-          <Container id="cW9kObdwG0KB8LBPXWArNA" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="mD8rIbcgKUumREGE1C_qPw" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="6P6XQVF2Ak6hC9Ub0KMhlg" name="Mass transfer rate (mucosa to portal vein blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_forTwoPores.PARAM_MassTransferMucosaToPveBloodCells" isDefault="1" displayUnit="µmol/min">
-                <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+              <Parameter id="Y9f07RbdpEe-HkByT6PlhA" name="Drug absorption rate (lumen to mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_DrugAbsorption_para" isDefault="1" displayUnit="µmol/min">
                 <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
               </Parameter>
+              <Parameter id="TiRZt_rXA02F7GR5Cw3ctg" name="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" isDefault="1" displayUnit="µmol/min">
+                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
+              <Parameter id="dGlqWvCelkuypys_kEe_Cg" name="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" isDefault="1" displayUnit="µmol/min">
+                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
             </Children>
           </Container>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="3kmxBkEAKUK8awGbymME4w" name="Lumen_rect_Rectum_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="N4-kBR_40ku5rWhp0VEzqA" secondNeighbor="TOYzThEJtkuhn2I6SIg6tA">
+      <NeighborhoodBuilder id="sE6pxSjUekyAN90q8D3eIg" name="Lumen_rect_Rectum_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="94Sc5RUGNUaXs_bDJ2T7lQ" secondNeighbor="KYsx3k5GgUu-J_d7og6DPQ">
         <Tags>
           <Tag value="Neighborhood: Rectum / Intracellular" />
         </Tags>
         <Children>
-          <Container id="_ipoq1KWREyWkURyC0u46A" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="sl75SriCqkiwQCye2KXb2w" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
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-              </Parameter>
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+              <Parameter id="zOV2RO8dCUKqmC31TBo6zg" name="Drug absorption rate (lumen to mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_DrugAbsorption_trans" isDefault="1" displayUnit="µmol/min">
                 <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
               </Parameter>
-              <Parameter id="7vRnccrkNUCkuPX7Utdq9Q" name="P_int_trans_cell_lum_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_cell_lum_factor" isDefault="1">
+              <Parameter id="ihxByGLUMUOdCAjmoymTUg" name="P_int_trans_cell_lum_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_cell_lum_factor" isDefault="1">
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               </Parameter>
-              <Parameter id="ZdggH5rBi0KyL53zLqdjhw" name="P_int_trans_lum_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_lum_cell_factor" isDefault="1">
+              <Parameter id="CPnN5c1HZ0GT6EO_7PaZNg" name="P_int_trans_lum_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_lum_cell_factor" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
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+              <Parameter id="ojq9Py4_q0WYrV4z4C81ww" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_K_cell_pls_Rectum" isDefault="1">
                 <Info min="0" flag="36" seq="1" ref="0" bb="2" group="67" />
               </Parameter>
-              <Parameter id="86mpRCraRk2aJI-WOAsO1g" name="pKa_pH_WS_cell_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F1" isDefault="1">
+              <Parameter id="ePZZfbfk0keKarFElpaLyg" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_Rectum" isDefault="1">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+              </Parameter>
+              <Parameter id="IneeS9Uv70Kbfu_7zkFqlg" name="pKa_pH_WS_cell_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F1" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="5rfZFTeZ8kOqvf4AhSbTQA" name="pKa_pH_WS_cell_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F3" isDefault="1">
+              <Parameter id="uQyexJiOUE2iOgSdocHGYg" name="pKa_pH_WS_cell_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F2" isDefault="1">
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               </Parameter>
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+              <Parameter id="7CXeWP4guk6K7YmFJuwB8Q" name="pKa_pH_WS_cell_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F3" isDefault="1">
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               </Parameter>
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+              <Parameter id="lf16Gk0SIEG6KfNnsjnH8Q" name="pKa_pH_WS_cell_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K1" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
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+              <Parameter id="pVzStNOAx0qddhpPMuX8qg" name="pKa_pH_WS_cell_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K2" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
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+              <Parameter id="sNhdrZ4GzESJesH0pd6wkg" name="pKa_pH_WS_cell_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K3" isDefault="1">
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               </Parameter>
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+              <Parameter id="0m-VpGVQDEu1Qbmh49y8gw" name="pKa_pH_WS_cell_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K4" isDefault="1">
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               </Parameter>
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+              <Parameter id="Mo2CiqA0QUqbEeyQxrzHpg" name="pKa_pH_WS_cell_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K5" isDefault="1">
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               </Parameter>
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+              <Parameter id="knReB75iu0uUFmPqs13QLA" name="pKa_pH_WS_cell_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K6" isDefault="1">
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+              <Parameter id="Y9mub9KQsEiPRfG0i_2UCA" name="pKa_pH_WS_cell_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K7" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
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+              <Parameter id="eNY8PpTw6UyYLwyMCktbaQ" name="pKa_pH_WS_cell_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K8" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
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+              <Parameter id="jX8xMB3Qo0q9fNldzMOlrw" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F1" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
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-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+              <Parameter id="jgTcEDaL1kW1O1wW-tnyTw" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F2" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="crB_DrSQTUunhad95Iu_rg" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K2" isDefault="1">
+              <Parameter id="EIA67JHHoUKFh5m-zoCi6Q" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F3" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="9ym0t0M5ikm22lOmyznjGA" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F3" isDefault="1">
+              <Parameter id="Vf4DWHJpY0OPi8jWXU18jA" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K1" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="gOLaRHyjl0ySUoPHTzTV5w" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K3" isDefault="1">
+              <Parameter id="kr5orm-74Eyobpj-y_kPjQ" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K2" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="vlnWr6Mq3ki0CJa-MCa7hg" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K4" isDefault="1">
+              <Parameter id="rpm4_xjJAESZcurjm3mGPQ" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K3" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="nrfHS-Mi-EePlzFjthprjA" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K5" isDefault="1">
+              <Parameter id="6ABfmvKDx0C0TCQ2RCMFeA" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K4" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="-OsjFxKvHUOkTfwRge3UlQ" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K6" isDefault="1">
+              <Parameter id="Hrpd2CbOpEKkVxD8vER9oQ" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K5" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="MNXlRLXG4Eef5DWiXnkm7g" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K7" isDefault="1">
+              <Parameter id="pxELMt1z-UOTZGDCOQDB7g" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K6" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="9BXLFb6tpkGxYP3bh-YDZQ" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K8" isDefault="1">
+              <Parameter id="Qr-mp3M-WEenTrEreFCjrA" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K7" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="Lh1RkgmRy02uCYOmsp5s7g" name="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" isDefault="1" displayUnit="µmol/min">
-                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+              <Parameter id="HJxgh7tWDES82svRno5MNg" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K8" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="U6B0mKku6UW4DURm1JIYPQ" name="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" isDefault="1" displayUnit="µmol/min">
+              <Parameter id="miN5FJnOpEeui-iY18X1XQ" name="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" isDefault="1" displayUnit="µmol/min">
                 <Info flag="52" seq="1" ref="0" bb="2" group="117" />
               </Parameter>
-              <Parameter id="XWpa50S9bECjpbPXskyNIw" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K1" isDefault="1">
-                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              <Parameter id="f5rZgkPXJUCAk7uMsufvbg" name="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" isDefault="1" displayUnit="µmol/min">
+                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
               </Parameter>
             </Children>
           </Container>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="c-mWmU7GwUGapCikgQ2pHg" name="Lumen_rect_Rectum_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="N4-kBR_40ku5rWhp0VEzqA" secondNeighbor="Yd0rccV71UKsC54RMkELFQ">
+      <NeighborhoodBuilder id="RhlD_Rmgt0Gnl67WZXWwpQ" name="Rectum_pls_PortalVein_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="8f8l-2PnRkC7BevNFjoHJw" secondNeighbor="d626iVqs-ESin5Db2bAqWg">
         <Tags>
-          <Tag value="Neighborhood: Rectum / Plasma" />
+          <Tag value="Neighborhood: Plasma / Plasma" />
         </Tags>
         <Children>
-          <Container id="bZDtRLB-Tk6p2s5UZk_TfA" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="GmFGYtD99k-NkvdKXgwAYA" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="58RXevM4BEGsCO1rNYkzpA" name="Drug absorption rate (lumen to mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_DrugAbsorption_para" isDefault="1" displayUnit="µmol/min">
+              <Parameter id="B_pTVPWdA0K-mSi-j1-Wrg" name="Mass transfer rate (mucosa to portal vein plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_forTwoPores.PARAM_MassTransferMucosaToPvePlasma" isDefault="1" displayUnit="µmol/min">
+                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                 <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
               </Parameter>
-              <Parameter id="YFQIqOWw7EuTbSgb_bz-Kw" name="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" isDefault="1" displayUnit="µmol/min">
-                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
-              </Parameter>
-              <Parameter id="KM9Qscsp1EOjazvOnV0ocg" name="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" isDefault="1" displayUnit="µmol/min">
-                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+            </Children>
+          </Container>
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="IsgEF_TlMUOA-cnGqa3bmw" name="Rectum_bc_PortalVein_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="Y-P-HpyhwkCHswnsdTF2gg" secondNeighbor="J7qhrNHWA0i3ePh_JHm2LQ">
+        <Tags>
+          <Tag value="Neighborhood: BloodCells / BloodCells" />
+        </Tags>
+        <Children>
+          <Container id="__594rEOWUqthdIlKvdAGg" name="MoleculeProperties" mode="Logical" containerType="Other">
+            <Children>
+              <Parameter id="XBkKIk1yyEertP4gYMtScg" name="Mass transfer rate (mucosa to portal vein blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_forTwoPores.PARAM_MassTransferMucosaToPveBloodCells" isDefault="1" displayUnit="µmol/min">
+                <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
               </Parameter>
             </Children>
           </Container>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="SmC05qzS7E2-aJmhgWMOyA" name="PortalVein_pls_PortalVein_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="5TpyW0Sd9USQGXc2frzUgA" secondNeighbor="oz2_zRPfzk-ZhQqUyIQ6kg">
+      <NeighborhoodBuilder id="NXe8lSRHWU6G6aVqeC0Apw" name="PortalVein_pls_PortalVein_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="d626iVqs-ESin5Db2bAqWg" secondNeighbor="J7qhrNHWA0i3ePh_JHm2LQ">
         <Tags>
           <Tag value="Neighborhood: Plasma / BloodCells" />
         </Tags>
         <Children>
-          <Container id="qWzl3fUeukyXg2To2OHL7A" name="MoleculeProperties" mode="Logical" containerType="Other" />
-          <Parameter id="xghlhnoY5UelPOejH8-SAw" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls_Blood_Organ" isDefault="1" displayUnit="cm²">
+          <Container id="RotaiH0j-UeqUYnEjxwSxQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Parameter id="QISI-Ghdl0Gmcr0eqt7ZfQ" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls_Blood_Organ" isDefault="1" displayUnit="cm²">
             <Tags>
               <Tag value="Neighborhood: Plasma / BloodCells" />
             </Tags>
@@ -19806,48 +19879,64 @@
           </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="Kzu06dQNG0SVxy399JceEg" name="Skin_bc_VenousBlood_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="ETS9QOw3Sk2oQeM3yJxElw" secondNeighbor="BvN_npw9ekupr6uHYGaj_g">
+      <NeighborhoodBuilder id="0FXIIYe_i0mFZwBdWNNkbg" name="Skin_bc_VenousBlood_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="8ItszmLwQEa_HitvX4V2Uw" secondNeighbor="s69zFizy-UefsPiLLFllaw">
         <Tags>
           <Tag value="Neighborhood: BloodCells / BloodCells" />
         </Tags>
         <Children>
-          <Container id="5Xy9RRg510ionJ__C15Dtw" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="YTZ6xdW7ekWYCz6ZxjZ13A" name="MoleculeProperties" mode="Logical" containerType="Other" />
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="BjzGye3g3EqGV20WbE1yUQ" name="Skin_end_Skin_ecl" mode="Logical" containerType="Neighborhood" firstNeighbor="najPJ3KIqEqTOT8-gEWAZA" secondNeighbor="0MjJnhA0s063jmqn9J-j4Q">
+        <Tags>
+          <Tag value="Neighborhood: Endosome / EndosomalClearance" />
+        </Tags>
+        <Children>
+          <Container id="tnmkaIaiHUOWidn1hU4xYg" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="YhxaU7Tn2kKCTO9SNC-nqA" name="Skin_int_Skin_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="373I9UgD8UmsrzVNFrHxEg" secondNeighbor="pp8uYV6iI0KvfWayj1DdIA">
+      <NeighborhoodBuilder id="YhH2HRUuMkGed0UrHJf8jw" name="Skin_end_Skin_int" mode="Logical" containerType="Neighborhood" firstNeighbor="najPJ3KIqEqTOT8-gEWAZA" secondNeighbor="Cc6tKfnFuUS4c_VddhBd9Q">
+        <Tags>
+          <Tag value="Neighborhood: Endosome / Interstitial" />
+        </Tags>
+        <Children>
+          <Container id="SZi6__nwv0uUj9Q7ZrT4Fw" name="MoleculeProperties" mode="Logical" containerType="Other" />
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="GTsFJ2CUNEW3d5ZCIyCUig" name="Skin_int_Skin_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="Cc6tKfnFuUS4c_VddhBd9Q" secondNeighbor="2zGInN6_00WmEn7Im5FCoA">
         <Tags>
           <Tag value="Neighborhood: Interstitial / Intracellular" />
         </Tags>
         <Children>
-          <Container id="asnbeapaZ0q6sFPzVi_d5w" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="EwU6E4fAp0-o271k9PaLBA" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="wK8yGe2NpUuS9Zt1x7i8Cw" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="69" />
-              </Parameter>
-              <Parameter id="Zpl-j8ddO02-pu-TTCIrmQ" name="P (interstitial-&gt;intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" isDefault="1" displayUnit="cm/min">
+              <Parameter id="UNviLXLUc0qHnwPVJjMWVA" name="P (interstitial-&gt;intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" isDefault="1" displayUnit="cm/min">
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="78" />
               </Parameter>
-              <Parameter id="J1fP3cqkb0i8o7FyIqQibw" name="P (intracellular-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" isDefault="1" displayUnit="cm/min">
+              <Parameter id="tpReGpsd2U6znN7yAALUbA" name="P (intracellular-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" isDefault="1" displayUnit="cm/min">
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="76" />
               </Parameter>
-              <Parameter id="_zqMMX2kP0aiOkya6OvUKg" name="P*SA interstitial -&gt; intracellular" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" isDefault="1" displayUnit="l/min">
+              <Parameter id="fN7TTiz5LkKLwl6uMr95hw" name="P*SA interstitial -&gt; intracellular" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" isDefault="1" displayUnit="l/min">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="oshaq8HWfUqgBVww8X4jAQ" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
+              <Parameter id="Vmij9q3gwUmwIVoTrRqsEw" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="wGtZc9kEjkuDL_BMFHJtZA" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
+              <Parameter id="SUuY7tbweUaz9CKv0UZ5VA" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="ta1lsX_DzkS7MIDtUGvwDg" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
-              </Parameter>
-              <Parameter id="80KtEKgbT0CHFSM-GzjY3w" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
+              <Parameter id="ht7_ft9ZYUiqRmmCBxOfgQ" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
+              <Parameter id="Vsr_GO6NnEGSuWphKysIGw" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="69" />
+              </Parameter>
+              <Parameter id="0tEgeAFlj0uuZtxsMpH7Dw" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+              </Parameter>
             </Children>
           </Container>
-          <Parameter id="mqmcYALC8EenGH8J5FX2yQ" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_skn" isDefault="1" displayUnit="cm²">
+          <Parameter id="s6C-tmReD0y33Y0EGQ9kiA" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_skn" isDefault="1" displayUnit="cm²">
             <Tags>
               <Tag value="Neighborhood: Interstitial / Intracellular" />
             </Tags>
@@ -19855,63 +19944,85 @@
           </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="1NTyK3i4g0iO4iaXKxVZsw" name="Skin_end_Skin_ecl" mode="Logical" containerType="Neighborhood" firstNeighbor="kZhE-uX3kk2qHIxpXjHeCA" secondNeighbor="eDJJFajIZ0qqc5SSL9V05w">
+      <NeighborhoodBuilder id="uumk1xmFh0ixd3jbESEGag" name="Skin_int_VenousBlood_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="Cc6tKfnFuUS4c_VddhBd9Q" secondNeighbor="JxP9aCWtgUGhXH_R7w1Z2Q">
         <Tags>
-          <Tag value="Neighborhood: Endosome / EndosomalClearance" />
+          <Tag value="Neighborhood: Interstitial / Plasma" />
+        </Tags>
+        <Children>
+          <Container id="PfJhSass6EGOt2pw2alndw" name="MoleculeProperties" mode="Logical" containerType="Other" />
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="MsILG_VhNUu4b04pet52LA" name="Skin_pls_Skin_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="1O7Xx6qzDEKO8BkNiCdrgQ" secondNeighbor="8ItszmLwQEa_HitvX4V2Uw">
+        <Tags>
+          <Tag value="Neighborhood: Plasma / BloodCells" />
+        </Tags>
+        <Children>
+          <Container id="so9ReBOAUEutTdcL7xCJZQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Parameter id="ajimvpg0BUGpygDYZ0UJfA" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" isDefault="1" displayUnit="cm²">
+            <Tags>
+              <Tag value="Neighborhood: Plasma / BloodCells" />
+            </Tags>
+            <Info min="0" flag="122" seq="17" ref="0" bb="32" group="104" />
+          </Parameter>
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="82tePbbbo0mtZucAirl99A" name="Skin_pls_Skin_end" mode="Logical" containerType="Neighborhood" firstNeighbor="1O7Xx6qzDEKO8BkNiCdrgQ" secondNeighbor="najPJ3KIqEqTOT8-gEWAZA">
+        <Tags>
+          <Tag value="Neighborhood: Plasma / Endosome" />
         </Tags>
         <Children>
-          <Container id="wIv7ahZLrEOrvzrNJE5qMQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="VMUrtDGEhkCL0EWxa1nuaQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="llQHNI7Yakm6kx4xQlX3rQ" name="Skin_pls_Skin_int" mode="Logical" containerType="Neighborhood" firstNeighbor="XqtoJLmkfUuYtaf2I2jTlg" secondNeighbor="373I9UgD8UmsrzVNFrHxEg">
+      <NeighborhoodBuilder id="Ezo4TNO_7kWwMTiX-ptT3g" name="Skin_pls_Skin_int" mode="Logical" containerType="Neighborhood" firstNeighbor="1O7Xx6qzDEKO8BkNiCdrgQ" secondNeighbor="Cc6tKfnFuUS4c_VddhBd9Q">
         <Tags>
           <Tag value="Neighborhood: Plasma / Interstitial" />
         </Tags>
         <Children>
-          <Container id="bUNUq5IzN0alZT62vZcQtQ" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="NHen9HPhSk6zk3AjNBtkqQ" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="6F0y_htT7UyG8ltgIeLOnA" name="Radius ratio (solute/small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_gamma_s" isDefault="1">
-                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="116" />
-              </Parameter>
-              <Parameter id="LqBfdMnIFESG6hnur9RFlw" name="P (large endothelial pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial_l" isDefault="1" displayUnit="cm/min">
+              <Parameter id="JndLoddGS0COTlySIYSNsw" name="P (large endothelial pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial_l" isDefault="1" displayUnit="cm/min">
                 <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="79" />
               </Parameter>
-              <Parameter id="_JMNDgc0IESEtKVeVU5pkQ" name="P (plasma&lt;-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial" isDefault="1" displayUnit="cm/min">
+              <Parameter id="34yzlepkXUihiTeMPK8iRg" name="P (plasma&lt;-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial" isDefault="1" displayUnit="cm/min">
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                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="77" />
               </Parameter>
-              <Parameter id="ZeIF9aK330u9WqNlZStb8w" name="P (small endothelial pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial_s" isDefault="1" displayUnit="cm/min">
+              <Parameter id="ho2fgcsRskC7Afs8LhQd2Q" name="P (small endothelial pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial_s" isDefault="1" displayUnit="cm/min">
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                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="80" />
               </Parameter>
-              <Parameter id="Wlv6O_tvy0aYK9Os5DMdsg" name="Partition coefficient (interstitial/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" isDefault="1">
+              <Parameter id="0MrL6uGdAEGqFOsIucfbHA" name="Partition coefficient (interstitial/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" isDefault="1">
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="70" />
               </Parameter>
-              <Parameter id="a4CmBYhuu0i7i6detkCGpw" name="Peclet number (large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CalcPecletNumber.PecletNumber_l" isDefault="1">
+              <Parameter id="ZQghWcAJ00ay6tbVGc72Fg" name="Peclet number (large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CalcPecletNumber.PecletNumber_l" isDefault="1">
                 <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="116" />
               </Parameter>
-              <Parameter id="ynp8qy84EEeDXJdsDbvqxg" name="Peclet number (small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CalcPecletNumber.PecletNumber_s" isDefault="1">
+              <Parameter id="q2GRyOrKWkeE2pJowFqh0g" name="Peclet number (small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CalcPecletNumber.PecletNumber_s" isDefault="1">
                 <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="116" />
               </Parameter>
-              <Parameter id="kUJPKnOmPEu_YAj326nriw" name="Reflection coefficient (large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_sigma_l" isDefault="1">
+              <Parameter id="f3NfDpN-P0CyglZNwTtvQg" name="Radius ratio (solute/large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_gamma_l" isDefault="1">
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-                <Info min="0" flag="58" seq="1" ref="0" bb="2" group="89" />
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="116" />
               </Parameter>
-              <Parameter id="S9jIytkqnkmK6nxBBq67NQ" name="Radius ratio (solute/large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_gamma_l" isDefault="1">
+              <Parameter id="Qw_tDg-L-0-Fq7V_qC7jPQ" name="Radius ratio (solute/small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_gamma_s" isDefault="1">
                 <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                 <Info min="0" flag="52" seq="1" ref="0" bb="2" group="116" />
               </Parameter>
-              <Parameter id="f9AmJ9A2AEykHz4gh_hypg" name="Reflection coefficient (small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_sigma_s" isDefault="1">
+              <Parameter id="XorIbMwhPkyvsiYhFdEXZA" name="Reflection coefficient (large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_sigma_l" isDefault="1">
+                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                <Info min="0" flag="58" seq="1" ref="0" bb="2" group="89" />
+              </Parameter>
+              <Parameter id="VxhR5Kk7-EW77oUOAGdwaw" name="Reflection coefficient (small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_sigma_s" isDefault="1">
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               </Parameter>
             </Children>
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-          <Parameter id="GkXoeAj7Nku0Ph4fyuyKBg" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" isDefault="1" displayUnit="cm²">
+          <Parameter id="TZtWTRQc4EG_tUzuKZRNag" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" isDefault="1" displayUnit="cm²">
             <Tags>
               <Tag value="Neighborhood: Plasma / Interstitial" />
             </Tags>
@@ -19920,110 +20031,72 @@
           </Parameter>
         </Children>
       </NeighborhoodBuilder>
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-        </Tags>
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-          <Container id="noCL846KTkqXInkvIMrdfA" name="MoleculeProperties" mode="Logical" containerType="Other" />
-          <Parameter id="FIWelGwrGEamwMnZhWOO0w" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" isDefault="1" displayUnit="cm²">
-            <Tags>
-              <Tag value="Neighborhood: Plasma / BloodCells" />
-            </Tags>
-            <Info min="0" flag="122" seq="17" ref="0" bb="32" group="104" />
-          </Parameter>
-        </Children>
-      </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="akwzjZIMTkWNfpJ_CwHYuA" name="Skin_pls_VenousBlood_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="XqtoJLmkfUuYtaf2I2jTlg" secondNeighbor="lg3JPjAHSUaKoE7vwc_rTw">
+      <NeighborhoodBuilder id="43EB2995UUOXI4YU1mbRGw" name="Skin_pls_VenousBlood_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="1O7Xx6qzDEKO8BkNiCdrgQ" secondNeighbor="JxP9aCWtgUGhXH_R7w1Z2Q">
         <Tags>
           <Tag value="Neighborhood: Plasma / Plasma" />
         </Tags>
         <Children>
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-        </Children>
-      </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="8-KsWNhHVUyCIANMfowwMQ" name="Skin_int_VenousBlood_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="373I9UgD8UmsrzVNFrHxEg" secondNeighbor="lg3JPjAHSUaKoE7vwc_rTw">
-        <Tags>
-          <Tag value="Neighborhood: Interstitial / Plasma" />
-        </Tags>
-        <Children>
-          <Container id="N_imQSuoEEK-rusipBnfBw" name="MoleculeProperties" mode="Logical" containerType="Other" />
-        </Children>
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-      <NeighborhoodBuilder id="zLncNTxFhUGaa_ZmXkfOyg" name="Skin_end_Skin_int" mode="Logical" containerType="Neighborhood" firstNeighbor="kZhE-uX3kk2qHIxpXjHeCA" secondNeighbor="373I9UgD8UmsrzVNFrHxEg">
-        <Tags>
-          <Tag value="Neighborhood: Endosome / Interstitial" />
-        </Tags>
-        <Children>
-          <Container id="A7uqnFrreESmK0TW0D45qA" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="46lJyp7lQkyCVtgvgS6jHA" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="Az4LdU2VlkC-xIm8TX1a1Q" name="Skin_pls_Skin_end" mode="Logical" containerType="Neighborhood" firstNeighbor="XqtoJLmkfUuYtaf2I2jTlg" secondNeighbor="kZhE-uX3kk2qHIxpXjHeCA">
-        <Tags>
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-        </Tags>
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-          <Container id="xgADZQbiFUaRCPoD-2WbLw" name="MoleculeProperties" mode="Logical" containerType="Other" />
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-      <NeighborhoodBuilder id="nEjdgSZ6xk21q0Qbu9pXPA" name="Spleen_bc_PortalVein_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="09bGeC4CvkWoBzLgbyrP4g" secondNeighbor="oz2_zRPfzk-ZhQqUyIQ6kg">
+      <NeighborhoodBuilder id="bLJEM7JlEEiQgkZ-yghetQ" name="Spleen_bc_PortalVein_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="L_KVwSudLEGk42Q8mLUZ1Q" secondNeighbor="J7qhrNHWA0i3ePh_JHm2LQ">
         <Tags>
           <Tag value="Neighborhood: BloodCells / BloodCells" />
         </Tags>
         <Children>
-          <Container id="DZ80lm2HR0KTDa_shDDBYg" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="CzrGtdJfYEy3sygh9eeP2A" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="SKnmlA7Sr0SiRPaKKya1IA" name="Spleen_end_Spleen_ecl" mode="Logical" containerType="Neighborhood" firstNeighbor="ztar9rDAak-m6S6ACVkMkQ" secondNeighbor="eDJJFajIZ0qqc5SSL9V05w">
+      <NeighborhoodBuilder id="BG698cyiRkSbJpzs-LViVQ" name="Spleen_end_Spleen_ecl" mode="Logical" containerType="Neighborhood" firstNeighbor="rIsOdJNcdUG9BZnPvWtnbA" secondNeighbor="0MjJnhA0s063jmqn9J-j4Q">
         <Tags>
           <Tag value="Neighborhood: Endosome / EndosomalClearance" />
         </Tags>
         <Children>
-          <Container id="zNmMllEsEUuvP4HSJ9PJ_Q" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="-wMJNQ0bpkae5SiZr-BePg" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="Y6BEOHa2N0euJsWOt7eQvg" name="Spleen_end_Spleen_int" mode="Logical" containerType="Neighborhood" firstNeighbor="ztar9rDAak-m6S6ACVkMkQ" secondNeighbor="dUGq5smYp02DPmodznUV4A">
+      <NeighborhoodBuilder id="j4AHmYYKNEO1XkRr8-b1Pw" name="Spleen_end_Spleen_int" mode="Logical" containerType="Neighborhood" firstNeighbor="rIsOdJNcdUG9BZnPvWtnbA" secondNeighbor="5WIKRUNL402_dIB3czf98g">
         <Tags>
           <Tag value="Neighborhood: Endosome / Interstitial" />
         </Tags>
         <Children>
-          <Container id="v1MW5qORrEyUjMa-LvyuLQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="s3_b1vfHPECN4t5Dll_RVQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="HATF4to4bk2Ivb3tjTlTag" name="Spleen_int_Spleen_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="dUGq5smYp02DPmodznUV4A" secondNeighbor="hcROPsJqIE-fUXIu9z8Iqw">
+      <NeighborhoodBuilder id="appObPBWpUGAh76y975SnA" name="Spleen_int_Spleen_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="5WIKRUNL402_dIB3czf98g" secondNeighbor="wuBnciIuSUGPD6xYPo--vA">
         <Tags>
           <Tag value="Neighborhood: Interstitial / Intracellular" />
         </Tags>
         <Children>
-          <Container id="lXbkpPHo3kWl4_Q5J0NhVg" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="23VUOqsUrUqAfhGUdfmLCg" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="y7ThFKLdcEmG2PmuprXR8Q" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
+              <Parameter id="9jntz21wcEuGkGIHSOjGpQ" name="P (interstitial-&gt;intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" isDefault="1" displayUnit="cm/min">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="78" />
+              </Parameter>
+              <Parameter id="QYYfG-EWAEWkpOL60BMXmQ" name="P (intracellular-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" isDefault="1" displayUnit="cm/min">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="76" />
+              </Parameter>
+              <Parameter id="iikLjcmU20K6-BTZiT-QeQ" name="P*SA interstitial -&gt; intracellular" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" isDefault="1" displayUnit="l/min">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="UzvXQhB--0-HzyAvIHVo6Q" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="_yO0ufksrE2NsyoDlhTV3Q" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
+              <Parameter id="ZHmy1W6pF0iQ4FJNhPibYQ" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="IbW_VWo3Eki_FN4fLr1OYg" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
+              <Parameter id="YxFz2dmu1UeUiR3M18-uHA" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="B5fh3UHIDESPTUQ2Gj1Yqg" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
+              <Parameter id="0SHdcaNTv0esUP6u54bspw" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="69" />
               </Parameter>
-              <Parameter id="uYJKjvhOJEyhNMtc-aV2ew" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
+              <Parameter id="GQ29Ejgoq0umElUCqQjLYQ" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
               </Parameter>
-              <Parameter id="-OtIwEZy-0-VbVu_DsP_5g" name="P (intracellular-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" isDefault="1" displayUnit="cm/min">
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="76" />
-              </Parameter>
-              <Parameter id="7JIEyASHtUuM86F-d4PkOg" name="P (interstitial-&gt;intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" isDefault="1" displayUnit="cm/min">
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="78" />
-              </Parameter>
-              <Parameter id="xx3-82i9y0mJIgHVmcVqfw" name="P*SA interstitial -&gt; intracellular" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" isDefault="1" displayUnit="l/min">
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
-              </Parameter>
             </Children>
           </Container>
-          <Parameter id="cAk1Sh7GeUCBGWk0ommwBg" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_spl" isDefault="1" displayUnit="cm²">
+          <Parameter id="4tFs84K6CUG1n-eKSZqt1Q" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_spl" isDefault="1" displayUnit="cm²">
             <Tags>
               <Tag value="Neighborhood: Interstitial / Intracellular" />
             </Tags>
@@ -20031,21 +20104,29 @@
           </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="UAysCY9dDkmaMtTwD1bRlg" name="Spleen_pls_PortalVein_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="9Fe1IZB_tEKPcqvJAmybMA" secondNeighbor="5TpyW0Sd9USQGXc2frzUgA">
+      <NeighborhoodBuilder id="VHdA2DIAkkelUYHt8SsUUA" name="Spleen_int_VenousBlood_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="5WIKRUNL402_dIB3czf98g" secondNeighbor="JxP9aCWtgUGhXH_R7w1Z2Q">
+        <Tags>
+          <Tag value="Neighborhood: Interstitial / Plasma" />
+        </Tags>
+        <Children>
+          <Container id="9XmlSxJUyEKbi_QjThX9JA" name="MoleculeProperties" mode="Logical" containerType="Other" />
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="ig-bzG5oCkqFqTyW5A_Sqw" name="Spleen_pls_PortalVein_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="jkTc5JbBPkGr-ZHYsEDFfg" secondNeighbor="d626iVqs-ESin5Db2bAqWg">
         <Tags>
           <Tag value="Neighborhood: Plasma / Plasma" />
         </Tags>
         <Children>
-          <Container id="jQcr3rl9FkKlpYLBptqkVQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="DELqrLREb0yqlYrsqWAYtw" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="VjVKUb8gckGPdRfkCvvNZQ" name="Spleen_pls_Spleen_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="9Fe1IZB_tEKPcqvJAmybMA" secondNeighbor="09bGeC4CvkWoBzLgbyrP4g">
+      <NeighborhoodBuilder id="3kTqXaTyOUSYfvhvc2yAdA" name="Spleen_pls_Spleen_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="jkTc5JbBPkGr-ZHYsEDFfg" secondNeighbor="L_KVwSudLEGk42Q8mLUZ1Q">
         <Tags>
           <Tag value="Neighborhood: Plasma / BloodCells" />
         </Tags>
         <Children>
-          <Container id="B75cHhvlgEm4DoBlI9D3PA" name="MoleculeProperties" mode="Logical" containerType="Other" />
-          <Parameter id="Ho4sY9al-UGhlMRDDGuJXg" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" isDefault="1" displayUnit="cm²">
+          <Container id="zeB9SvBCHUSSgSRZ7qZ36Q" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Parameter id="Uh50LrfTM0GTspwihi_7Vg" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" isDefault="1" displayUnit="cm²">
             <Tags>
               <Tag value="Neighborhood: Plasma / BloodCells" />
             </Tags>
@@ -20053,63 +20134,63 @@
           </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="UOkAHwNfxk63WmAiYw-H5g" name="Spleen_int_VenousBlood_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="dUGq5smYp02DPmodznUV4A" secondNeighbor="lg3JPjAHSUaKoE7vwc_rTw">
+      <NeighborhoodBuilder id="NidcCdIr0kaWaIrLh4MH3Q" name="Spleen_pls_Spleen_end" mode="Logical" containerType="Neighborhood" firstNeighbor="jkTc5JbBPkGr-ZHYsEDFfg" secondNeighbor="rIsOdJNcdUG9BZnPvWtnbA">
         <Tags>
-          <Tag value="Neighborhood: Interstitial / Plasma" />
+          <Tag value="Neighborhood: Plasma / Endosome" />
         </Tags>
         <Children>
-          <Container id="NWI0qDtyhkSeY4fBrtrpWw" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="nhkxANMFAk2MnOYt-0pnlg" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="Ha-BCG1xbEq7Tzdq__alqw" name="Spleen_pls_Spleen_int" mode="Logical" containerType="Neighborhood" firstNeighbor="9Fe1IZB_tEKPcqvJAmybMA" secondNeighbor="dUGq5smYp02DPmodznUV4A">
+      <NeighborhoodBuilder id="6SHtncD560-P6dcODcFh_Q" name="Spleen_pls_Spleen_int" mode="Logical" containerType="Neighborhood" firstNeighbor="jkTc5JbBPkGr-ZHYsEDFfg" secondNeighbor="5WIKRUNL402_dIB3czf98g">
         <Tags>
           <Tag value="Neighborhood: Plasma / Interstitial" />
         </Tags>
         <Children>
-          <Container id="zBblDTKoHk659bTt8UEGgQ" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="rii7bx5PZUGxBHpzRisn_w" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="Q9lQS4hevEW3kxtT7mjJOg" name="Partition coefficient (interstitial/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" isDefault="1">
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="70" />
-              </Parameter>
-              <Parameter id="hEvmt0fIxkCYTQP_YXNEog" name="P (large endothelial pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial_l" isDefault="1" displayUnit="cm/min">
+              <Parameter id="YyUwRj7NSEKqpfUNyVM0aA" name="P (large endothelial pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial_l" isDefault="1" displayUnit="cm/min">
                 <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="79" />
               </Parameter>
-              <Parameter id="7LGEX1Mk-0G09mbBxJdmIg" name="P (small endothelial pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial_s" isDefault="1" displayUnit="cm/min">
+              <Parameter id="zAtLbmyCqE2_M3YKdjsneQ" name="P (plasma&lt;-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial" isDefault="1" displayUnit="cm/min">
+                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="77" />
+              </Parameter>
+              <Parameter id="gegG2aatYU6nzw4Kpwr1kQ" name="P (small endothelial pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial_s" isDefault="1" displayUnit="cm/min">
                 <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="80" />
               </Parameter>
-              <Parameter id="xLfMzhOhG0aSl5ojI_Fulw" name="Peclet number (large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CalcPecletNumber.PecletNumber_l" isDefault="1">
+              <Parameter id="7JiHK-juwE-ECbncXtmSmg" name="Partition coefficient (interstitial/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" isDefault="1">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="70" />
+              </Parameter>
+              <Parameter id="p7_3lCupzEKFRrAy_Si1Yg" name="Peclet number (large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CalcPecletNumber.PecletNumber_l" isDefault="1">
                 <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="116" />
               </Parameter>
-              <Parameter id="FGJStZDXSUOTmIfs7ZOrLg" name="Peclet number (small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CalcPecletNumber.PecletNumber_s" isDefault="1">
+              <Parameter id="qVuSliZjWkGBdsjsLfj_4g" name="Peclet number (small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CalcPecletNumber.PecletNumber_s" isDefault="1">
                 <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="116" />
               </Parameter>
-              <Parameter id="TImwYC1jf0ikIOpMg5juig" name="Radius ratio (solute/large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_gamma_l" isDefault="1">
+              <Parameter id="LTz0o27RukK9hdqVcfxrng" name="Radius ratio (solute/large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_gamma_l" isDefault="1">
                 <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                 <Info min="0" flag="52" seq="1" ref="0" bb="2" group="116" />
               </Parameter>
-              <Parameter id="TD3X8RRSpkeFX5lCPZQqLw" name="Radius ratio (solute/small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_gamma_s" isDefault="1">
+              <Parameter id="-_qqs4iiT0q6AeWVSRXVIw" name="Radius ratio (solute/small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_gamma_s" isDefault="1">
                 <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                 <Info min="0" flag="52" seq="1" ref="0" bb="2" group="116" />
               </Parameter>
-              <Parameter id="7-mA9blnf06vkhTCe6abaA" name="Reflection coefficient (large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_sigma_l" isDefault="1">
+              <Parameter id="Lxvry1L3DUeZANuHHNCDvQ" name="Reflection coefficient (large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_sigma_l" isDefault="1">
                 <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                 <Info min="0" flag="58" seq="1" ref="0" bb="2" group="89" />
               </Parameter>
-              <Parameter id="NhWbkGV2lECzS533yaqfCQ" name="Reflection coefficient (small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_sigma_s" isDefault="1">
+              <Parameter id="6oK8Gqu6Z0yiIcOXWqor8Q" name="Reflection coefficient (small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_sigma_s" isDefault="1">
                 <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                 <Info min="0" flag="58" seq="1" ref="0" bb="2" group="90" />
               </Parameter>
-              <Parameter id="45m8rQZPX0CP8pWyipR0gA" name="P (plasma&lt;-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial" isDefault="1" displayUnit="cm/min">
-                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="77" />
-              </Parameter>
             </Children>
           </Container>
-          <Parameter id="wfVOK9aJKk2YCjCyGwXSmQ" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" isDefault="1" displayUnit="cm²">
+          <Parameter id="FfDH8qBun0aIzeA6b31n5A" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" isDefault="1" displayUnit="cm²">
             <Tags>
               <Tag value="Neighborhood: Plasma / Interstitial" />
             </Tags>
@@ -20118,198 +20199,124 @@
           </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="sATB4Pj9xEyvqzDmv-uALg" name="Spleen_pls_Spleen_end" mode="Logical" containerType="Neighborhood" firstNeighbor="9Fe1IZB_tEKPcqvJAmybMA" secondNeighbor="ztar9rDAak-m6S6ACVkMkQ">
-        <Tags>
-          <Tag value="Neighborhood: Plasma / Endosome" />
-        </Tags>
-        <Children>
-          <Container id="5DEE4pQU5kS9WHlgLgF-Zg" name="MoleculeProperties" mode="Logical" containerType="Other" />
-        </Children>
-      </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="n2QfmIxp2E-gTx_o6OS_lA" name="EndogenousIgG_int_EndogenousIgG_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="folugTTTwUipwB8ko_vFIQ" secondNeighbor="dbuTODyT70KcEkric73Orw">
+      <NeighborhoodBuilder id="Mm_mqsDVL0eINVGbwMWvoQ" name="EndogenousIgG_iggend_EndogenousIgG_ecl" mode="Logical" containerType="Neighborhood" firstNeighbor="agzD72z7DEqnZcYFQ79ngg" secondNeighbor="g2-FoiUD-EWvaNY_ICtKKA">
         <Tags>
-          <Tag value="Neighborhood: Interstitial / Plasma" />
+          <Tag value="Neighborhood: IgG_Endosome / EndosomalClearance" />
         </Tags>
         <Children>
-          <Container id="W8wm0RLnTUiPVHumJYdKFg" name="MoleculeProperties" mode="Logical" containerType="Other" />
-          <Parameter id="ygqBLSfgxkS9dcAXVVdMJw" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int_igg" isDefault="1" displayUnit="cm²">
-            <Tags>
-              <Tag value="Neighborhood: Interstitial / Plasma" />
-            </Tags>
-            <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-            <Info min="0" flag="54" seq="1" ref="0" bb="32" group="106" />
-          </Parameter>
+          <Container id="_h8pq41mqEi5fL6Z-ixLeA" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="yr9chRWQ1kmCRjKb7LZ4mw" name="EndogenousIgG_iggend_EndogenousIgG_int" mode="Logical" containerType="Neighborhood" firstNeighbor="7y0uknsa4E-rfc1F2Z5tQA" secondNeighbor="folugTTTwUipwB8ko_vFIQ">
+      <NeighborhoodBuilder id="xQjYbZT5t0-ZukJKrCy2PA" name="EndogenousIgG_iggend_EndogenousIgG_int" mode="Logical" containerType="Neighborhood" firstNeighbor="agzD72z7DEqnZcYFQ79ngg" secondNeighbor="xjHFXTZquEWkfWzBcXjgPA">
         <Tags>
           <Tag value="Neighborhood: IgG_Endosome / Interstitial" />
         </Tags>
         <Children>
-          <Container id="IGq4T6tw8ECsMNYCDfp3bA" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="C6Owe0FFNU6B6ZzK0sJA6Q" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="CHdW7AuPl0GoECAzjLAiSQ" name="EndogenousIgG_iggend_EndogenousIgG_ecl" mode="Logical" containerType="Neighborhood" firstNeighbor="7y0uknsa4E-rfc1F2Z5tQA" secondNeighbor="PVsE91ttqUaGpEkv6S3jdg">
+      <NeighborhoodBuilder id="50het89WfUGGyumsit7uDQ" name="EndogenousIgG_iggsrc_EndogenousIgG_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="QhXFNRAUBUGAOtpHhUG9Qg" secondNeighbor="Vexf6JzgdkuDQwd2-5r0xw">
         <Tags>
-          <Tag value="Neighborhood: IgG_Endosome / EndosomalClearance" />
+          <Tag value="Neighborhood: IgG_Source / Plasma" />
         </Tags>
         <Children>
-          <Container id="yjbxTqHNyUqBrSpPnQ7GQA" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="3lLA18UI8EqVxetfhDBUHg" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="BRAq5a8Zgka93_vodFSXgA" name="EndogenousIgG_iggsrc_EndogenousIgG_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="2kLO2rZsFU6ORv3GlfLi-w" secondNeighbor="dbuTODyT70KcEkric73Orw">
+      <NeighborhoodBuilder id="K1nh9EcoTkylLTUxWL1jLQ" name="EndogenousIgG_int_EndogenousIgG_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="xjHFXTZquEWkfWzBcXjgPA" secondNeighbor="Vexf6JzgdkuDQwd2-5r0xw">
         <Tags>
-          <Tag value="Neighborhood: IgG_Source / Plasma" />
+          <Tag value="Neighborhood: Interstitial / Plasma" />
         </Tags>
         <Children>
-          <Container id="OVOzZ1wflUmCkEHotWH08g" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="NsNwMauQf0Kfy_4wsge8zg" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Parameter id="cpZ4zZazZkWciYi5QhCWZw" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int_igg" isDefault="1" displayUnit="cm²">
+            <Tags>
+              <Tag value="Neighborhood: Interstitial / Plasma" />
+            </Tags>
+            <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+            <Info min="0" flag="54" seq="1" ref="0" bb="32" group="106" />
+          </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="m3ZBvAQeqEq3jcfVHmiOdw" name="EndogenousIgG_pls_EndogenousIgG_iggend" mode="Logical" containerType="Neighborhood" firstNeighbor="dbuTODyT70KcEkric73Orw" secondNeighbor="7y0uknsa4E-rfc1F2Z5tQA">
+      <NeighborhoodBuilder id="eBQb8IiL_kCBNfmONiDfMQ" name="EndogenousIgG_pls_EndogenousIgG_iggend" mode="Logical" containerType="Neighborhood" firstNeighbor="Vexf6JzgdkuDQwd2-5r0xw" secondNeighbor="agzD72z7DEqnZcYFQ79ngg">
         <Tags>
           <Tag value="Neighborhood: Plasma / IgG_Endosome" />
         </Tags>
         <Children>
-          <Container id="XPFJMkVsy0mAWHlwI1A0Mg" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="oZ5VMMaQqkSAqsPKTx2iGQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
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-      <NeighborhoodBuilder id="P_aGO6567Euxgy4KAaLkFg" name="Saliva_slv_Saliva_slv" mode="Logical" containerType="Neighborhood" firstNeighbor="kVddIOjBn0CZ1HvUQU3eag" secondNeighbor="vPFJuXlB4kCa_JiNyQJJEA">
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+              <Parameter id="KVaif0OaAE6_UE9IDJuvXg" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionSaliva_PKSim.PARAM_K_cell_pls_slv" isDefault="1">
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+              <Parameter id="g5LWc44mMEG1RuCrlfJSAw" name="SalivaPlasmaRatio" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionSaliva_PKSim.PARAM_SalivaPlasmaRatio" isDefault="1">
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+      <NeighborhoodBuilder id="UC4bIsaZsUqGKVLHpbvNhw" name="Duodenum_end_Duodenum_ecl" mode="Logical" containerType="Neighborhood" firstNeighbor="1hJKls6_H02uJRPrES2dVA" secondNeighbor="0MjJnhA0s063jmqn9J-j4Q">
         <Tags>
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         <Children>
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         <Tags>
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+              <Parameter id="5RYWDwZZxkKYgHkT7_urpw" name="P (interstitial-&gt;intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_int_cell_Mucosa" isDefault="1" displayUnit="cm/min">
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+              <Parameter id="pRzrW2-S00Cw8X1UnT8-HA" name="P (intracellular-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_cell_int_Mucosa" isDefault="1" displayUnit="cm/min">
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+              <Parameter id="MMM2xi65i0OhZm_P0S-SVg" name="P*SA interstitial -&gt; intracellular" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" isDefault="1" displayUnit="l/min">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
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+              <Parameter id="EXafXy3d_kOLjnsju5DloA" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
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+              <Parameter id="dL4u8e3hs0ee_BsurHo-Bg" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
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+              <Parameter id="MMV92W5cGkO_84MGoGc2xw" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
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+              <Parameter id="mMCP6TfbtU24g7r0VbDEcw" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
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-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
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+          <Parameter id="5UuBpQnfk0GQOFJh254dgg" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mucosa_duo" isDefault="1" displayUnit="cm²">
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               <Tag value="Small intestine  neighborhood" />
@@ -20318,134 +20325,143 @@
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+          <Container id="UWvXK-i0B0W7UcJ4egIc3Q" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Parameter id="83-obP96Nka8QbHe4YMFOA" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" isDefault="1" displayUnit="cm²">
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               <Tag value="Small intestine  neighborhood" />
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-            <Info min="0" flag="122" seq="22" ref="0" bb="32" group="104" />
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+      <NeighborhoodBuilder id="Qac1ySJWj0u6fVVa1LjJPA" name="Duodenum_pls_Duodenum_end" mode="Logical" containerType="Neighborhood" firstNeighbor="0kFKBI9cUEeUTIqKlJNFrg" secondNeighbor="1hJKls6_H02uJRPrES2dVA">
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+          <Tag value="Neighborhood: Plasma / Endosome" />
+          <Tag value="Small intestine  neighborhood" />
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+          <Container id="Hu7NPZiVfEuxkMRYxEsi-A" name="MoleculeProperties" mode="Logical" containerType="Other" />
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+              <Parameter id="1lfNIh8jAUiXCzpYmIAltQ" name="P (plasma&lt;-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial" isDefault="1" displayUnit="cm/min">
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+              <Parameter id="qUOlCJOzbEyErGWVrV5ZeA" name="P (small endothelial pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial_s" isDefault="1" displayUnit="cm/min">
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+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="148" />
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+              <Parameter id="CnP3UjPxAka9UKeOV_NCNg" name="Peclet number (large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CalcPecletNumber.PecletNumber_l" isDefault="1">
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+              <Parameter id="gmr7R3eqIUuvldXh5WYnAw" name="Peclet number (small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CalcPecletNumber.PecletNumber_s" isDefault="1">
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+              <Parameter id="ZF0F0Vbhk0mm_wxhiFKuUg" name="Radius ratio (solute/large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_gamma_l" isDefault="1">
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+              <Parameter id="GEQJTfbl_kmdAvCFRfOXyA" name="Radius ratio (solute/small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_gamma_s" isDefault="1">
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+              <Parameter id="adIPF0TQaEC6rXssXrmzFQ" name="Reflection coefficient (large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_sigma_l" isDefault="1">
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+              <Parameter id="deEHpbccBEON-C-Rq-1_AA" name="Reflection coefficient (small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_sigma_s" isDefault="1">
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+          <Parameter id="LfpcVpHzvESzLf80gjUXcw" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" isDefault="1" displayUnit="cm²">
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+          <Tag value="Small intestine  neighborhood" />
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+              <Parameter id="E6xt8OS140usnGKXhB6ORg" name="P*SA interstitial -&gt; intracellular" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" isDefault="1" displayUnit="l/min">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="msf4WfAe_0esOll8VMXKtg" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="qWJtUFxcdUOsyfhOtSKQjw" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
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+              <Parameter id="_DYY69cG9kSPFsLadB2hTA" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
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+              <Parameter id="WpY_58x6OUyGPvEJ3Y4rrQ" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
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+              <Parameter id="_sA0LBnJRECB-SP1aHdqYw" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
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+          <Parameter id="KNfj_cgoaEWL_dCLiCEv7A" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mucosa_uje" isDefault="1" displayUnit="cm²">
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@@ -20454,152 +20470,143 @@
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+      <NeighborhoodBuilder id="_3z5SLoN_0af2xDNgYNQrA" name="UpperJejunum_pls_UpperJejunum_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="HD4pskxza0qRnIR9Xit2aA" secondNeighbor="43ryQ7QICUyzCzsGc7Evpg">
         <Tags>
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           <Tag value="Small intestine  neighborhood" />
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-          <Container id="VsbOaYm6k0Caa58CRX8cJQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="UPyPq4JPo0iy5sxYy0xOKw" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Parameter id="SmhyFvUNlk6AT1-rAHR2DQ" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" isDefault="1" displayUnit="cm²">
+            <Tags>
+              <Tag value="Neighborhood: Plasma / BloodCells" />
+              <Tag value="Small intestine  neighborhood" />
+            </Tags>
+            <Info min="0" flag="122" seq="22" ref="0" bb="32" group="104" />
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+      <NeighborhoodBuilder id="D4phlpDTSUGK-3kJb_eLTQ" name="UpperJejunum_pls_UpperJejunum_end" mode="Logical" containerType="Neighborhood" firstNeighbor="HD4pskxza0qRnIR9Xit2aA" secondNeighbor="qBzxt-UQmUmrfuDgbrmGVA">
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-          <Container id="CwNjIFiSV0Cryag1SVxGYw" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="ra7tiroOtUSLKOl-Et_Pfw" name="MoleculeProperties" mode="Logical" containerType="Other" />
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+      <NeighborhoodBuilder id="5KRuk5zpu0a9pAD1gqB_rw" name="UpperJejunum_pls_UpperJejunum_int" mode="Logical" containerType="Neighborhood" firstNeighbor="HD4pskxza0qRnIR9Xit2aA" secondNeighbor="YxtZTHDCL06WvjrJPu6N3g">
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+          <Container id="sBS4S63kNUWRmVMxFaewXQ" name="MoleculeProperties" mode="Logical" containerType="Other">
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+              <Parameter id="qSvPItmjS0m8hfJDhix4rA" name="P (large endothelial pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial_l" isDefault="1" displayUnit="cm/min">
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+              <Parameter id="OyUaHqCP5U6GdkGUBASZsw" name="P (plasma&lt;-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial" isDefault="1" displayUnit="cm/min">
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+              <Parameter id="9op7q01apkK7O6iXawKttg" name="P (small endothelial pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial_s" isDefault="1" displayUnit="cm/min">
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+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="80" />
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-              <Parameter id="qho3Ispse0WaWjkOQPkkQA" name="Partition coefficient (interstitial/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" isDefault="1">
+              <Parameter id="MKQ0LJ_KVkGf3yhLYHhMLA" name="Partition coefficient (interstitial/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" isDefault="1">
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-              <Parameter id="8pjLBp-XgUGsKBCHuZTREQ" name="Peclet number (small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CalcPecletNumber.PecletNumber_s" isDefault="1">
+              <Parameter id="8Ba-SaxSe0eDbGlmbzgcow" name="Peclet number (large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CalcPecletNumber.PecletNumber_l" isDefault="1">
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-              <Parameter id="-Ie0vM9LDU2UpHb--Zvw8w" name="Peclet number (large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CalcPecletNumber.PecletNumber_l" isDefault="1">
+              <Parameter id="ZJHlcEArhUm2SDYArQEYhw" name="Peclet number (small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CalcPecletNumber.PecletNumber_s" isDefault="1">
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-              <Parameter id="U-j3uTqM80iAYz_1DURSFw" name="P (large endothelial pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial_l" isDefault="1" displayUnit="cm/min">
+              <Parameter id="lTn1QowSh0CKT12SFaipMg" name="Radius ratio (solute/large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_gamma_l" isDefault="1">
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+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="116" />
               </Parameter>
-              <Parameter id="yLDLx4zl10y6W1IfcV_j4A" name="P (plasma&lt;-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial" isDefault="1" displayUnit="cm/min">
+              <Parameter id="fft5j1oR_02Uz9vH4Vuaxw" name="Radius ratio (solute/small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_gamma_s" isDefault="1">
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-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="134" />
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="116" />
               </Parameter>
-              <Parameter id="p0qAbzTiXUmKw1fN9nvB7A" name="P (small endothelial pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial_s" isDefault="1" displayUnit="cm/min">
+              <Parameter id="hT-cxUBvMECUaJdDv3dY1A" name="Reflection coefficient (large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_sigma_l" isDefault="1">
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-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="80" />
+                <Info min="0" flag="58" seq="1" ref="0" bb="2" group="89" />
+              </Parameter>
+              <Parameter id="RLKiklbaUEuf4ZKdZicLaw" name="Reflection coefficient (small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_sigma_s" isDefault="1">
+                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                <Info min="0" flag="58" seq="1" ref="0" bb="2" group="90" />
               </Parameter>
             </Children>
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-          <Parameter id="BrIAESr-YUm5AIivFXscmA" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" isDefault="1" displayUnit="cm²">
+          <Parameter id="xRfIc8e8bUu_v9SV-PxqHg" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" isDefault="1" displayUnit="cm²">
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               <Tag value="Neighborhood: Plasma / Interstitial" />
               <Tag value="Small intestine  neighborhood" />
             </Tags>
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-            <Info min="0" flag="122" seq="20" ref="0" bb="32" group="106" />
+            <Info min="0" flag="122" seq="19" ref="0" bb="32" group="106" />
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       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="7-t3tVPzMUisUtOZ_LLdiA" name="LowerJejunum_pls_LowerJejunum_end" mode="Logical" containerType="Neighborhood" firstNeighbor="-tHCOtnB1U2z7aMrUzfzJQ" secondNeighbor="rIaw61dxMkWQYOa1GJJmKA">
+      <NeighborhoodBuilder id="rI9p_-HOk02C42mi4uO8KQ" name="LowerJejunum_end_LowerJejunum_ecl" mode="Logical" containerType="Neighborhood" firstNeighbor="nGmORWNShk6c7ck4uoKR9g" secondNeighbor="0MjJnhA0s063jmqn9J-j4Q">
         <Tags>
-          <Tag value="Neighborhood: Plasma / Endosome" />
+          <Tag value="Neighborhood: Endosome / EndosomalClearance" />
           <Tag value="Small intestine  neighborhood" />
         </Tags>
         <Children>
-          <Container id="2_k6_Ez46U62fwcPl2fH2g" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="KgIbC8TOlUKZ6NUxIwmExw" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="tcY8OeWLHEyHFyQdG-VVsQ" name="LowerJejunum_pls_LowerJejunum_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="-tHCOtnB1U2z7aMrUzfzJQ" secondNeighbor="Fzo84SjMx0Ck9ipgh_6h1w">
+      <NeighborhoodBuilder id="ci-7HrC88kusX24697CiGg" name="LowerJejunum_end_LowerJejunum_int" mode="Logical" containerType="Neighborhood" firstNeighbor="nGmORWNShk6c7ck4uoKR9g" secondNeighbor="P2t6gquZ3EKgJEnSeI3X3g">
         <Tags>
-          <Tag value="Neighborhood: Plasma / BloodCells" />
+          <Tag value="Neighborhood: Endosome / Interstitial" />
           <Tag value="Small intestine  neighborhood" />
         </Tags>
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-          <Container id="qtGT9v2VLEuor5zKbpHuDg" name="MoleculeProperties" mode="Logical" containerType="Other" />
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-              <Tag value="Small intestine  neighborhood" />
-            </Tags>
-            <Info min="0" flag="122" seq="23" ref="0" bb="32" group="104" />
-          </Parameter>
+          <Container id="BvWZ3zE0cE6ZDbSwQ7DaFw" name="MoleculeProperties" mode="Logical" containerType="Other" />
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-      <NeighborhoodBuilder id="rdsbCH4mXEmA3qt0APnWQw" name="LowerJejunum_int_LowerJejunum_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="hWIJNL39KEqDcHwJ2WVNAQ" secondNeighbor="BC5XIDg8L0Kh6isr8xLJnw">
+      <NeighborhoodBuilder id="eH8C9ypZLk6rt37juyvKIg" name="LowerJejunum_int_LowerJejunum_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="P2t6gquZ3EKgJEnSeI3X3g" secondNeighbor="vbzZRD1fTUGB9xYY7QdQcA">
         <Tags>
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           <Tag value="Small intestine  neighborhood" />
         </Tags>
         <Children>
-          <Container id="pHLKUcHRMU2VvBBTR5HmiQ" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="6NoEKT2rG0qzBVacqXyVAQ" name="MoleculeProperties" mode="Logical" containerType="Other">
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+              <Parameter id="_9JvE1ugKUmdg_MJCPPOQg" name="P (interstitial-&gt;intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_int_cell_Mucosa" isDefault="1" displayUnit="cm/min">
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+              <Parameter id="CE-DPkI8dUuxeTrRSFqRrA" name="P (intracellular-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_cell_int_Mucosa" isDefault="1" displayUnit="cm/min">
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="133" />
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+              <Parameter id="Ct55iG_640WuZyKQcGCNIQ" name="P*SA interstitial -&gt; intracellular" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" isDefault="1" displayUnit="l/min">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="hjGG77Rrj0Ge_CF_daiRpQ" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
+              <Parameter id="M-Hi6Xl9OEKPNYZsIEyDhA" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
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-              <Parameter id="O-a3gpmNckGT5bzZgjAbTQ" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
+              <Parameter id="ytKedR0gI0qkOJO3N2C3gA" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
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               </Parameter>
-              <Parameter id="6tcH0xkLuUOUc4eD9rQdvw" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
+              <Parameter id="zVocvHyAMEqhnLBwyXKJ4A" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
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-              <Parameter id="g7vMTTyuBES0388l4UDPCA" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
+              <Parameter id="wMv1zy3eeE2bTOuHYzEJQA" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="147" />
               </Parameter>
+              <Parameter id="Aoijk2iN4kWkHK3Ze7flFg" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+              </Parameter>
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-          <Parameter id="MonKEYo6ZUO2wwIU3cjSjw" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mucosa_lje" isDefault="1" displayUnit="cm²">
+          <Parameter id="PCrreBy4rEy42ourj3isaw" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mucosa_lje" isDefault="1" displayUnit="cm²">
             <Tags>
               <Tag value="Neighborhood: Interstitial / Intracellular" />
               <Tag value="Small intestine  neighborhood" />
@@ -20608,723 +20615,723 @@
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+      <NeighborhoodBuilder id="HcaCTHlEt0KXpQsSopP2NQ" name="LowerJejunum_pls_LowerJejunum_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="9M_w50lqQkq4lTBvJwwuig" secondNeighbor="agnOGTrLQES0KmSTwvqI5w">
         <Tags>
-          <Tag value="Neighborhood: Interstitial / Intracellular" />
+          <Tag value="Neighborhood: Plasma / BloodCells" />
           <Tag value="Small intestine  neighborhood" />
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-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
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-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
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-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
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+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="147" />
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+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
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+      <NeighborhoodBuilder id="nNqK07QfcU6Adfjoen3M8w" name="LowerIleum_pls_LowerIleum_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="ZxmY6nNSm0GN9qpb4qkq_w" secondNeighbor="qqf54SjWUE2QJPKX23ms4g">
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+              <Parameter id="tMZ99V8QYU-KBYCB5efNhg" name="P (large endothelial pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial_l" isDefault="1" displayUnit="cm/min">
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+              <Parameter id="KWaEpFfftkWqohANtvSR5w" name="P (plasma&lt;-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial" isDefault="1" displayUnit="cm/min">
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+              <Parameter id="VL87WuqYNEikpgF5PVsmyA" name="P (small endothelial pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial_s" isDefault="1" displayUnit="cm/min">
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+              <Parameter id="PAv7nWAI60CWPuVyVHnJEQ" name="Partition coefficient (interstitial/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" isDefault="1">
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+              <Parameter id="PVNkzk_5VkaVbIjBRxYqzw" name="Reflection coefficient (large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_sigma_l" isDefault="1">
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+          <Parameter id="8EN3GHW9PUe2rohLqChu_g" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" isDefault="1" displayUnit="cm²">
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+        <Tags>
+          <Tag value="Large intestine  neighborhood" />
+          <Tag value="Neighborhood: Endosome / EndosomalClearance" />
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+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="133" />
+              </Parameter>
+              <Parameter id="EnS2hYbkfEiGxGi8O0pnaw" name="P*SA interstitial -&gt; intracellular" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" isDefault="1" displayUnit="l/min">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="BBACvsaMi0qoPYOcq_NTRQ" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
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+              <Parameter id="MIQ5uE6V00uD2ajXXuu1Pg" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
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+              <Parameter id="I8U-gnyUjkCYWba8mQnFUg" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
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+              <Parameter id="LXSAesiUd0O5PxLO29XmGA" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
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+              <Parameter id="hBcFC6HRS0ezTeLV_geYnA" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
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+          <Parameter id="3TVIRKC5VkOSy4n6E1uCIQ" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mucosa_cae" isDefault="1" displayUnit="cm²">
             <Tags>
               <Tag value="Large intestine  neighborhood" />
               <Tag value="Neighborhood: Interstitial / Intracellular" />
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+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="b9eHLPWSJki0bpwwJMo_Yg" name="Caecum_pls_Caecum_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="6rbF-W8rIUq5hZ8odtvzrQ" secondNeighbor="a9ee82hQMEOJZglG6y718g">
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+          <Tag value="Large intestine  neighborhood" />
+          <Tag value="Neighborhood: Plasma / BloodCells" />
+        </Tags>
+        <Children>
+          <Container id="NZ_UGkevA06YAZqryoOnUQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
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+            <Tags>
+              <Tag value="Large intestine  neighborhood" />
+              <Tag value="Neighborhood: Plasma / BloodCells" />
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-      <NeighborhoodBuilder id="MrKTcYr0LUSutG_dUSqv_A" name="ColonAscendens_pls_ColonAscendens_int" mode="Logical" containerType="Neighborhood" firstNeighbor="m5wMdFXfeU2GNaT-cMXNww" secondNeighbor="wCHFevfEAUa4gfNBCIYr1A">
+      <NeighborhoodBuilder id="Toln13cSyEKyJmSCTE-uFw" name="Caecum_pls_Caecum_end" mode="Logical" containerType="Neighborhood" firstNeighbor="6rbF-W8rIUq5hZ8odtvzrQ" secondNeighbor="VkZeqlnX2k2zVyoiwzUaag">
+        <Tags>
+          <Tag value="Large intestine  neighborhood" />
+          <Tag value="Neighborhood: Plasma / Endosome" />
+        </Tags>
+        <Children>
+          <Container id="HyYeRG9eVkC-d1Mnc9F3PA" name="MoleculeProperties" mode="Logical" containerType="Other" />
+        </Children>
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+      <NeighborhoodBuilder id="85ekixzIBEOzLCt6USL3Eg" name="Caecum_pls_Caecum_int" mode="Logical" containerType="Neighborhood" firstNeighbor="6rbF-W8rIUq5hZ8odtvzrQ" secondNeighbor="RKmMizWZwUixJ0AvRAZJEw">
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+          <Container id="2E4X4H9lhkiiJfun_GMv9w" name="MoleculeProperties" mode="Logical" containerType="Other">
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+              <Parameter id="9YBoatyaJkGdk-sCtRYF9A" name="P (large endothelial pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial_l" isDefault="1" displayUnit="cm/min">
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+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="134" />
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+              <Parameter id="ilw4VC-jEkSbgHMZT4s3cg" name="Partition coefficient (interstitial/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" isDefault="1">
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+              <Parameter id="m7i68-5m90mwyMatfJVHIA" name="Peclet number (large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CalcPecletNumber.PecletNumber_l" isDefault="1">
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+              <Parameter id="vO-lq8EiHk23E2ANh-rLyQ" name="Peclet number (small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CalcPecletNumber.PecletNumber_s" isDefault="1">
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+              <Parameter id="oE5Qpp6-s0uqFk0BMQifcg" name="Radius ratio (solute/large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_gamma_l" isDefault="1">
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+              <Parameter id="cs4On3-D40-lwVePJkLd9A" name="Radius ratio (solute/small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_gamma_s" isDefault="1">
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+              <Parameter id="9VTIlhlzwkK0gFOYeVvs-w" name="Reflection coefficient (large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_sigma_l" isDefault="1">
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+          <Parameter id="8VrmWwNkyUKHAjKi5cGtjA" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" isDefault="1" displayUnit="cm²">
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         <Tags>
           <Tag value="Large intestine  neighborhood" />
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+      <NeighborhoodBuilder id="D4eEfK-qu0WEA_0qkIHxVg" name="ColonAscendens_int_ColonAscendens_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="qJFpi2VrMUevujlAbgi63Q" secondNeighbor="S-Rw4kxIuk2Mzq3AJUGeAg">
         <Tags>
           <Tag value="Large intestine  neighborhood" />
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         <Children>
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+          <Container id="hy9DryKhQEyuOHHXKitvrg" name="MoleculeProperties" mode="Logical" containerType="Other">
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+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="135" />
+              </Parameter>
+              <Parameter id="5emI-AVUUUmY_KWYndc5Hw" name="P (intracellular-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_cell_int_Mucosa" isDefault="1" displayUnit="cm/min">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="133" />
+              </Parameter>
+              <Parameter id="OyZyz6R4LEyebHPdNyte6Q" name="P*SA interstitial -&gt; intracellular" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" isDefault="1" displayUnit="l/min">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="p2PafUcy3UKvH4nQhxA66g" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="U7gWuXczM0m1qOdBh7svNQ" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="_-ToZzUQOk684NWdTsVKkg" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="ilBxf5SF40eDUzAGSQzvww" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="147" />
+              </Parameter>
+              <Parameter id="hNzcmYD4YECnPCdnt2b4IQ" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
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+            <Tags>
+              <Tag value="Large intestine  neighborhood" />
+              <Tag value="Neighborhood: Interstitial / Intracellular" />
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+          <Container id="wHkoEuja00-PsVx2Gb5EiQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
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               <Tag value="Neighborhood: Plasma / BloodCells" />
             </Tags>
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+      <NeighborhoodBuilder id="9dOBqUi9dEmdoCgbCFwpJQ" name="ColonAscendens_pls_ColonAscendens_end" mode="Logical" containerType="Neighborhood" firstNeighbor="NXXWdgTHKkOgaKy-_Ihsfg" secondNeighbor="m3uhNYhC00O1U6ih730LVQ">
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+      <NeighborhoodBuilder id="NrVYAduvnUCrRyGnhu0-eg" name="ColonAscendens_pls_ColonAscendens_int" mode="Logical" containerType="Neighborhood" firstNeighbor="NXXWdgTHKkOgaKy-_Ihsfg" secondNeighbor="qJFpi2VrMUevujlAbgi63Q">
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+          <Container id="EbA86dhUT0Ggz6M1t6kzuQ" name="MoleculeProperties" mode="Logical" containerType="Other">
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+              <Parameter id="zxe9agySM0u9BBsjA-q1AA" name="P (large endothelial pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial_l" isDefault="1" displayUnit="cm/min">
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+              <Parameter id="Ovyinb0kI0yQ1rrE2pDkEg" name="P (plasma&lt;-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial" isDefault="1" displayUnit="cm/min">
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+              <Parameter id="wRtDDhbepEeG1zRV8SbLvw" name="P (small endothelial pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial_s" isDefault="1" displayUnit="cm/min">
+                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="80" />
+              </Parameter>
+              <Parameter id="vbsLZimcc0eEeV4KHgqzUg" name="Partition coefficient (interstitial/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" isDefault="1">
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+              <Parameter id="WL8IEjleY0udoTzH-ZGgVw" name="Peclet number (large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CalcPecletNumber.PecletNumber_l" isDefault="1">
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+              <Parameter id="Hy4wn5neqEikJVCLxNRsvA" name="Peclet number (small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CalcPecletNumber.PecletNumber_s" isDefault="1">
+                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="116" />
+              </Parameter>
+              <Parameter id="MLLkLXNhSEO3GQvQ2u_CaA" name="Radius ratio (solute/large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_gamma_l" isDefault="1">
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                 <Info min="0" flag="52" seq="1" ref="0" bb="2" group="116" />
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+              <Parameter id="HwIxz5vkLUGEWuXYKu3Zmg" name="Radius ratio (solute/small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_gamma_s" isDefault="1">
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                 <Info min="0" flag="52" seq="1" ref="0" bb="2" group="116" />
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+              <Parameter id="Io_mEkAokUyRk8atJkd-Tg" name="Reflection coefficient (large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_sigma_l" isDefault="1">
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                 <Info min="0" flag="58" seq="1" ref="0" bb="2" group="89" />
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+              <Parameter id="E507r4upskKlPts81KiO0w" name="Reflection coefficient (small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_sigma_s" isDefault="1">
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-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="80" />
-              </Parameter>
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+          <Parameter id="r9DwO-NnL0mE9n2oaKTPGQ" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" isDefault="1" displayUnit="cm²">
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               <Tag value="Neighborhood: Plasma / Interstitial" />
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+      <NeighborhoodBuilder id="TgdckQATqkyRX9gYZKEGUA" name="ColonTransversum_end_ColonTransversum_ecl" mode="Logical" containerType="Neighborhood" firstNeighbor="8HOX-hTtFEWc10EOdFIELg" secondNeighbor="0MjJnhA0s063jmqn9J-j4Q">
+        <Tags>
+          <Tag value="Large intestine  neighborhood" />
+          <Tag value="Neighborhood: Endosome / EndosomalClearance" />
+        </Tags>
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+          <Container id="8SMaAFxCUE2q7WMAtq6jeA" name="MoleculeProperties" mode="Logical" containerType="Other" />
+        </Children>
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+      <NeighborhoodBuilder id="n3p7C_C-I0uVSaXAz7WNQg" name="ColonTransversum_end_ColonTransversum_int" mode="Logical" containerType="Neighborhood" firstNeighbor="8HOX-hTtFEWc10EOdFIELg" secondNeighbor="bcrybuR9D06zpXiHiW4y8w">
+        <Tags>
+          <Tag value="Large intestine  neighborhood" />
+          <Tag value="Neighborhood: Endosome / Interstitial" />
+        </Tags>
+        <Children>
+          <Container id="IylEcTp7LEee9y_5qd-cCA" name="MoleculeProperties" mode="Logical" containerType="Other" />
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+          <Container id="3gCxWm3YWUKkEGy1SH3adA" name="MoleculeProperties" mode="Logical" containerType="Other">
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+              <Parameter id="UlPUgk8ddEuQ0exTzmNL1A" name="P (interstitial-&gt;intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_int_cell_Mucosa" isDefault="1" displayUnit="cm/min">
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+              <Parameter id="Olh5On5Dn0ywbktJl0pDGQ" name="P (intracellular-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_cell_int_Mucosa" isDefault="1" displayUnit="cm/min">
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+              <Parameter id="ShDL0C2VlEOnip-nQN_CHA" name="P*SA interstitial -&gt; intracellular" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" isDefault="1" displayUnit="l/min">
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+              <Parameter id="2qeNXswul02quOOPvut5WA" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
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-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="147" />
+              <Parameter id="dfNQvQBRPUObz0DJf3Qqjw" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="g0mXL97aj0a3RSIALBa3lA" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
+              <Parameter id="wja2SQgSGkKEifrftCixgg" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
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-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+              <Parameter id="i9iap_cCOkWkTHzh3I775Q" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="147" />
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-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+              <Parameter id="E4z45GSFikWkLzCpgbj-fw" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
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-          <Parameter id="MXjUdhM3vUWVgNwKRkzdYg" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mucosa_coltrans" isDefault="1" displayUnit="cm²">
+          <Parameter id="ztjtJsfVQE-Y0F78WNDdvA" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mucosa_coltrans" isDefault="1" displayUnit="cm²">
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               <Tag value="Large intestine  neighborhood" />
               <Tag value="Neighborhood: Interstitial / Intracellular" />
@@ -21333,152 +21340,143 @@
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+      <NeighborhoodBuilder id="PuRgx5KrekubQGbP4iY7hg" name="ColonTransversum_pls_ColonTransversum_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="dKKkV4FxmUC1PUPd2DghIQ" secondNeighbor="k7RtszIIWEWmNkArkmiZyw">
         <Tags>
           <Tag value="Large intestine  neighborhood" />
-          <Tag value="Neighborhood: Endosome / EndosomalClearance" />
+          <Tag value="Neighborhood: Plasma / BloodCells" />
         </Tags>
         <Children>
-          <Container id="dEK9kftNdE6oCZOHQtMHog" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="8MakonGmgE-toV_aOvU-Fg" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Parameter id="CeaG88XKSkGg28e_wc1tfg" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" isDefault="1" displayUnit="cm²">
+            <Tags>
+              <Tag value="Large intestine  neighborhood" />
+              <Tag value="Neighborhood: Plasma / BloodCells" />
+            </Tags>
+            <Info min="0" flag="122" seq="28" ref="0" bb="32" group="104" />
+          </Parameter>
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-      <NeighborhoodBuilder id="nKQ_9R_cQ0yGKN1z7ipKvg" name="ColonDescendens_end_ColonDescendens_ecl" mode="Logical" containerType="Neighborhood" firstNeighbor="g71YN1ccBEqBXIzaKQrckg" secondNeighbor="eDJJFajIZ0qqc5SSL9V05w">
+      <NeighborhoodBuilder id="2sHR9-QWzUOtyO8GFZfT5w" name="ColonTransversum_pls_ColonTransversum_end" mode="Logical" containerType="Neighborhood" firstNeighbor="dKKkV4FxmUC1PUPd2DghIQ" secondNeighbor="8HOX-hTtFEWc10EOdFIELg">
         <Tags>
           <Tag value="Large intestine  neighborhood" />
-          <Tag value="Neighborhood: Endosome / EndosomalClearance" />
+          <Tag value="Neighborhood: Plasma / Endosome" />
         </Tags>
         <Children>
-          <Container id="NKo4tIzPHEiwg-WFr4IlLA" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="2Y8irTQrhUSuXoAx_83fcg" name="MoleculeProperties" mode="Logical" containerType="Other" />
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+      <NeighborhoodBuilder id="p11D04Aug0afLfJWmSHWzQ" name="ColonTransversum_pls_ColonTransversum_int" mode="Logical" containerType="Neighborhood" firstNeighbor="dKKkV4FxmUC1PUPd2DghIQ" secondNeighbor="bcrybuR9D06zpXiHiW4y8w">
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+              <Parameter id="SOY5jW42Zke-0q6S2u5zzA" name="Peclet number (large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CalcPecletNumber.PecletNumber_l" isDefault="1">
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+              <Parameter id="gCvGtP61ZkSbMDF1LCWnDg" name="Peclet number (small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CalcPecletNumber.PecletNumber_s" isDefault="1">
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+              <Parameter id="L7ryF5PHy0qTXWWlwjiYyg" name="Radius ratio (solute/small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_gamma_s" isDefault="1">
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+              <Parameter id="C4M4Cz4MYkmLXCCw5AHTUQ" name="Reflection coefficient (small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_sigma_s" isDefault="1">
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+          <Parameter id="XL9Pcg9f8U2b_QsV9Mh27Q" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" isDefault="1" displayUnit="cm²">
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+      <NeighborhoodBuilder id="9tDjtxhOXEyohES2MxrMSA" name="ColonDescendens_end_ColonDescendens_ecl" mode="Logical" containerType="Neighborhood" firstNeighbor="8ldLU8DX4U6abUvycFtUEg" secondNeighbor="0MjJnhA0s063jmqn9J-j4Q">
         <Tags>
           <Tag value="Large intestine  neighborhood" />
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+          <Tag value="Neighborhood: Endosome / EndosomalClearance" />
         </Tags>
         <Children>
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         <Tags>
           <Tag value="Large intestine  neighborhood" />
-          <Tag value="Neighborhood: Plasma / BloodCells" />
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-              <Tag value="Neighborhood: Plasma / BloodCells" />
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+      <NeighborhoodBuilder id="MWR2DH4WIUSwaHMRba4Dxw" name="ColonDescendens_int_ColonDescendens_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="zrgwuEAKdEmyWNT7C0WyVw" secondNeighbor="WRzvpRIMeE6obqJjnbY-sQ">
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+          <Container id="7Q2BrkvkykWq0t9irDq25A" name="MoleculeProperties" mode="Logical" containerType="Other">
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+              <Parameter id="8w6U7ovLZkyHdqgARfvqsQ" name="P (interstitial-&gt;intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_int_cell_Mucosa" isDefault="1" displayUnit="cm/min">
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+              <Parameter id="5TON3mGjF0e9CUNv_jtznA" name="P (intracellular-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_cell_int_Mucosa" isDefault="1" displayUnit="cm/min">
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+              <Parameter id="iJPorsdW70uKByultpPVCA" name="P*SA interstitial -&gt; intracellular" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" isDefault="1" displayUnit="l/min">
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-              <Parameter id="Q1MMS7R3GUGzvojKT0BtQA" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
+              <Parameter id="h5Q6yYn3YUeIBVbDUElI2g" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
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+              <Parameter id="cKG2hMEEL0uSrmRsK_5lfg" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
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+              <Parameter id="hg01ZwAJIESYyzYzq3IhUg" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
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+              <Parameter id="ggn-MVMzOkayiJvT5w-yig" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
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+              <Parameter id="-6vWFxONI0Sy3jTsyJQn7A" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
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-          <Parameter id="aE36-i3GoUibxcrvfq-x0g" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mucosa_coldesc" isDefault="1" displayUnit="cm²">
+          <Parameter id="eEpuVu_F9EqzNrE90qHApQ" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mucosa_coldesc" isDefault="1" displayUnit="cm²">
             <Tags>
               <Tag value="Large intestine  neighborhood" />
               <Tag value="Neighborhood: Interstitial / Intracellular" />
@@ -21487,68 +21485,143 @@
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+      <NeighborhoodBuilder id="xo4CnCU9-E2q5lBE08J-8w" name="ColonDescendens_pls_ColonDescendens_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="jZAZ-gTMf0KikSh_Nm6c8Q" secondNeighbor="-WuEPhTZIUycjwSP04xTJw">
         <Tags>
           <Tag value="Large intestine  neighborhood" />
-          <Tag value="Neighborhood: Endosome / Interstitial" />
+          <Tag value="Neighborhood: Plasma / BloodCells" />
+        </Tags>
+        <Children>
+          <Container id="9QSOYoOvT0mwRXONdUmtWA" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Parameter id="V5V06HzHmU-G0UQTImw9-Q" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" isDefault="1" displayUnit="cm²">
+            <Tags>
+              <Tag value="Large intestine  neighborhood" />
+              <Tag value="Neighborhood: Plasma / BloodCells" />
+            </Tags>
+            <Info min="0" flag="122" seq="29" ref="0" bb="32" group="104" />
+          </Parameter>
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="kAMJO0Y3SUSzNOPu2BmLOA" name="ColonDescendens_pls_ColonDescendens_end" mode="Logical" containerType="Neighborhood" firstNeighbor="jZAZ-gTMf0KikSh_Nm6c8Q" secondNeighbor="8ldLU8DX4U6abUvycFtUEg">
+        <Tags>
+          <Tag value="Large intestine  neighborhood" />
+          <Tag value="Neighborhood: Plasma / Endosome" />
+        </Tags>
+        <Children>
+          <Container id="qQSjGx-IVkOEZWyV9QKV4Q" name="MoleculeProperties" mode="Logical" containerType="Other" />
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="tp0R7AEAW0i3hjcTxHBOgQ" name="ColonDescendens_pls_ColonDescendens_int" mode="Logical" containerType="Neighborhood" firstNeighbor="jZAZ-gTMf0KikSh_Nm6c8Q" secondNeighbor="zrgwuEAKdEmyWNT7C0WyVw">
+        <Tags>
+          <Tag value="Large intestine  neighborhood" />
+          <Tag value="Neighborhood: Plasma / Interstitial" />
         </Tags>
         <Children>
-          <Container id="eQO5TPQT6kSGFgeH1ihJcQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="c-eYEZRe6kKHGoPnYkMIXQ" name="MoleculeProperties" mode="Logical" containerType="Other">
+            <Children>
+              <Parameter id="y5qEy95E1EKr9s-GbVkqJw" name="P (large endothelial pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial_l" isDefault="1" displayUnit="cm/min">
+                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="79" />
+              </Parameter>
+              <Parameter id="eTrKTUEDTkWc6-OCRbd0fA" name="P (plasma&lt;-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial" isDefault="1" displayUnit="cm/min">
+                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="134" />
+              </Parameter>
+              <Parameter id="eX0MiJDmCEylitY3Dl2ghw" name="P (small endothelial pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial_s" isDefault="1" displayUnit="cm/min">
+                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="80" />
+              </Parameter>
+              <Parameter id="8l3DWWOWXkWo7EofxjA78g" name="Partition coefficient (interstitial/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" isDefault="1">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="148" />
+              </Parameter>
+              <Parameter id="xULzTpcokEKV-Dcz3Cqbpw" name="Peclet number (large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CalcPecletNumber.PecletNumber_l" isDefault="1">
+                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="116" />
+              </Parameter>
+              <Parameter id="j78QOGpbe06PP6hHwSaAdw" name="Peclet number (small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CalcPecletNumber.PecletNumber_s" isDefault="1">
+                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="116" />
+              </Parameter>
+              <Parameter id="2w9G9jHw-kWiHL0eTnywtQ" name="Radius ratio (solute/large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_gamma_l" isDefault="1">
+                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="116" />
+              </Parameter>
+              <Parameter id="h_44Uofs7EyrajpRtrQG3Q" name="Radius ratio (solute/small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_gamma_s" isDefault="1">
+                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="116" />
+              </Parameter>
+              <Parameter id="yqS83BTzSUas0Kq4bzyTOA" name="Reflection coefficient (large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_sigma_l" isDefault="1">
+                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                <Info min="0" flag="58" seq="1" ref="0" bb="2" group="89" />
+              </Parameter>
+              <Parameter id="5GVPJW8VHUio-wOeGLgqaA" name="Reflection coefficient (small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_sigma_s" isDefault="1">
+                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                <Info min="0" flag="58" seq="1" ref="0" bb="2" group="90" />
+              </Parameter>
+            </Children>
+          </Container>
+          <Parameter id="QudWR7xvm0yR_EKBkqYhBw" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" isDefault="1" displayUnit="cm²">
+            <Tags>
+              <Tag value="Large intestine  neighborhood" />
+              <Tag value="Neighborhood: Plasma / Interstitial" />
+            </Tags>
+            <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+            <Info min="0" flag="122" seq="26" ref="0" bb="32" group="106" />
+          </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="cQmoNpc6i0a973_DNigz1g" name="ColonSigmoid_end_ColonSigmoid_ecl" mode="Logical" containerType="Neighborhood" firstNeighbor="Z4c7wB5sl0K7_nqp7uDKWg" secondNeighbor="eDJJFajIZ0qqc5SSL9V05w">
+      <NeighborhoodBuilder id="c90MCCz7f0q52qDW-3kg3A" name="ColonSigmoid_end_ColonSigmoid_ecl" mode="Logical" containerType="Neighborhood" firstNeighbor="QAloCcgN-0iaMfqrp--wEQ" secondNeighbor="0MjJnhA0s063jmqn9J-j4Q">
         <Tags>
           <Tag value="Large intestine  neighborhood" />
           <Tag value="Neighborhood: Endosome / EndosomalClearance" />
         </Tags>
         <Children>
-          <Container id="aXTI7OsHQEydeGCNLk2zgA" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="jHX-cEw9B0m9fOGgmDXzyQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="n1AQUEMzDEa0KG2H9w43ww" name="ColonSigmoid_end_ColonSigmoid_int" mode="Logical" containerType="Neighborhood" firstNeighbor="Z4c7wB5sl0K7_nqp7uDKWg" secondNeighbor="d0rNGHjBGkStSpuA3K_WCw">
+      <NeighborhoodBuilder id="_SXRuGpA3EaqM0_0iE-OVg" name="ColonSigmoid_end_ColonSigmoid_int" mode="Logical" containerType="Neighborhood" firstNeighbor="QAloCcgN-0iaMfqrp--wEQ" secondNeighbor="ezmOoZjgZ0G730YeQlQEHA">
         <Tags>
           <Tag value="Large intestine  neighborhood" />
           <Tag value="Neighborhood: Endosome / Interstitial" />
         </Tags>
         <Children>
-          <Container id="1n40FsqIEEmowUU30bavyA" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="zUYm3jTV30aQ8Tf91V3UHQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="Ot9-2PfyRUiDFZUgznPPNA" name="ColonSigmoid_int_ColonSigmoid_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="d0rNGHjBGkStSpuA3K_WCw" secondNeighbor="ECAR3iZfl0CtlZHp7S_zaQ">
+      <NeighborhoodBuilder id="xd5vcN_Pq0WQmPg0Nb0D7w" name="ColonSigmoid_int_ColonSigmoid_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="ezmOoZjgZ0G730YeQlQEHA" secondNeighbor="XqUZ4UhE-EyE99zEOxxkNg">
         <Tags>
           <Tag value="Large intestine  neighborhood" />
           <Tag value="Neighborhood: Interstitial / Intracellular" />
         </Tags>
         <Children>
-          <Container id="3-07RqZUFUiRuQktl1tE3w" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="NwNIHMjL1UOqc9DGSupL0w" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="CdcVwlLxIUmRGcJw__R8FA" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+              <Parameter id="kkuCvZTnNUql0VmXLATWOQ" name="P (interstitial-&gt;intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_int_cell_Mucosa" isDefault="1" displayUnit="cm/min">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="135" />
               </Parameter>
-              <Parameter id="7L3Yp5aT3k6s0YV4_QTlWQ" name="P (intracellular-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_cell_int_Mucosa" isDefault="1" displayUnit="cm/min">
+              <Parameter id="mYgxNXtMv0KjpIo2L3diKg" name="P (intracellular-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_cell_int_Mucosa" isDefault="1" displayUnit="cm/min">
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="133" />
               </Parameter>
-              <Parameter id="9EDS_KwB1UC7HRnAU7SVJQ" name="P*SA interstitial -&gt; intracellular" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" isDefault="1" displayUnit="l/min">
+              <Parameter id="MkRvvGw2VkigmYy7QyHDwg" name="P*SA interstitial -&gt; intracellular" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" isDefault="1" displayUnit="l/min">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="YHZdCSb8-Uux-3voPe2xYQ" name="P (interstitial-&gt;intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_int_cell_Mucosa" isDefault="1" displayUnit="cm/min">
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="135" />
+              <Parameter id="uRSJ1_PJfkeLmjEEzLDuvQ" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="VYusjMtRu0WbIR_tayBMaQ" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
+              <Parameter id="kS4lNdUlNUW-wrO8YiWfVg" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="xJEos48ylESibKdH9yP5Dg" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
+              <Parameter id="CX9GW6Gn8kehuEpLgfbsfA" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="AmuKxAvuDEWcPZtfZCpqCQ" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
+              <Parameter id="l1DNS3KGGEWypPIVvbiYXQ" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="147" />
               </Parameter>
-              <Parameter id="FXLDwpi9TUKyyT_3KyndpQ" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
+              <Parameter id="yITtmMpJnkKY8rNzLiMQYg" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
               </Parameter>
             </Children>
           </Container>
-          <Parameter id="IZeNHTvKfUOX_rKUiHBpzQ" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mucosa_colsigm" isDefault="1" displayUnit="cm²">
+          <Parameter id="aCDIBZGomkCSWCAnKbsgKg" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mucosa_colsigm" isDefault="1" displayUnit="cm²">
             <Tags>
               <Tag value="Large intestine  neighborhood" />
               <Tag value="Neighborhood: Interstitial / Intracellular" />
@@ -21557,202 +21630,143 @@
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+      <NeighborhoodBuilder id="MXxUT2bckkOV8_nOzoc0CQ" name="ColonSigmoid_pls_ColonSigmoid_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="WV8-rtxb-kqkvGTxuUS_Vg" secondNeighbor="bjnkSvC4UkCPwACz1ooOVQ">
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           <Tag value="Neighborhood: Plasma / BloodCells" />
         </Tags>
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-          <Parameter id="6qutGcz8x0OsA8xipSCKjw" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" isDefault="1" displayUnit="cm²">
+          <Container id="sCTiaVQoI0esEkCj6ttGEw" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Parameter id="6JR3_BOVUUyaXeReLZUiQw" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" isDefault="1" displayUnit="cm²">
             <Tags>
               <Tag value="Large intestine  neighborhood" />
               <Tag value="Neighborhood: Plasma / BloodCells" />
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-              </Parameter>
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-              </Parameter>
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-              </Parameter>
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-              <Tag value="Large intestine  neighborhood" />
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-      <NeighborhoodBuilder id="vV_-2tipQUCMNx_C5i93jg" name="ColonSigmoid_pls_ColonSigmoid_end" mode="Logical" containerType="Neighborhood" firstNeighbor="wK5jXxrXl0-zE0K0MBqJ2g" secondNeighbor="Z4c7wB5sl0K7_nqp7uDKWg">
+      <NeighborhoodBuilder id="6dz7lVCdtEiPOrANWTSm3g" name="ColonSigmoid_pls_ColonSigmoid_end" mode="Logical" containerType="Neighborhood" firstNeighbor="WV8-rtxb-kqkvGTxuUS_Vg" secondNeighbor="QAloCcgN-0iaMfqrp--wEQ">
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           <Tag value="Large intestine  neighborhood" />
           <Tag value="Neighborhood: Plasma / Endosome" />
         </Tags>
         <Children>
-          <Container id="jcAS6NnMK0SfEEww65mvBg" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="ZQF8s70kr0KcNpvWDYcdVw" name="MoleculeProperties" mode="Logical" containerType="Other" />
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-      <NeighborhoodBuilder id="0vtl3cjckUO7vRa4ySTTpw" name="Rectum_pls_Rectum_int" mode="Logical" containerType="Neighborhood" firstNeighbor="Yd0rccV71UKsC54RMkELFQ" secondNeighbor="jL0phy_0okq1f1ayx6hWMw">
+      <NeighborhoodBuilder id="lNW7e9-Vik-lWKFgTEL4iQ" name="ColonSigmoid_pls_ColonSigmoid_int" mode="Logical" containerType="Neighborhood" firstNeighbor="WV8-rtxb-kqkvGTxuUS_Vg" secondNeighbor="ezmOoZjgZ0G730YeQlQEHA">
         <Tags>
           <Tag value="Large intestine  neighborhood" />
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         </Tags>
         <Children>
-          <Container id="F0gYuX3Xy0GhISjxOCsPBg" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="_pRO8fIJLka7OfHXvbuDaA" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="3Txz-2xWWEaIqByBfiVJqQ" name="P (small endothelial pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial_s" isDefault="1" displayUnit="cm/min">
+              <Parameter id="1ZTaJq199kW05QhvZGJtLg" name="P (large endothelial pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial_l" isDefault="1" displayUnit="cm/min">
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-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="80" />
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="79" />
               </Parameter>
-              <Parameter id="Zl3kKirutEqe8VHF7kQ-7w" name="P (large endothelial pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial_l" isDefault="1" displayUnit="cm/min">
+              <Parameter id="hmRHPVkVBEOZ5tOM7mob-A" name="P (plasma&lt;-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial" isDefault="1" displayUnit="cm/min">
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-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="79" />
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="134" />
+              </Parameter>
+              <Parameter id="gJ9EL_5i4kK4FeiMb3VsFQ" name="P (small endothelial pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial_s" isDefault="1" displayUnit="cm/min">
+                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="80" />
               </Parameter>
-              <Parameter id="YAbJAtGMW0CO-Aj_6WTAWA" name="Partition coefficient (interstitial/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" isDefault="1">
+              <Parameter id="VREHJNZKPUWlBIdnzxuPxg" name="Partition coefficient (interstitial/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" isDefault="1">
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="148" />
               </Parameter>
-              <Parameter id="eZCnPcm1U0mjCHnVm1qHeA" name="Peclet number (large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CalcPecletNumber.PecletNumber_l" isDefault="1">
+              <Parameter id="n3G3FYjyXkGBRNybcQ8Drg" name="Peclet number (large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CalcPecletNumber.PecletNumber_l" isDefault="1">
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                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="116" />
               </Parameter>
-              <Parameter id="w0oTcnratEK7ZvWDK14OPg" name="Peclet number (small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CalcPecletNumber.PecletNumber_s" isDefault="1">
+              <Parameter id="ImnPO7NzkkKxbUYc7cnSWQ" name="Peclet number (small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CalcPecletNumber.PecletNumber_s" isDefault="1">
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                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="116" />
               </Parameter>
-              <Parameter id="N_kdV3rQyEmjYE_Jy9iWGg" name="Radius ratio (solute/large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_gamma_l" isDefault="1">
+              <Parameter id="Cxgm5nEVaUCpLtd5JMyWAw" name="Radius ratio (solute/large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_gamma_l" isDefault="1">
                 <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                 <Info min="0" flag="52" seq="1" ref="0" bb="2" group="116" />
               </Parameter>
-              <Parameter id="o6rdaefvsUqi40dJqANXCg" name="Radius ratio (solute/small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_gamma_s" isDefault="1">
+              <Parameter id="l4lDl-9qJUyhvUI49MxS-Q" name="Radius ratio (solute/small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_gamma_s" isDefault="1">
                 <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                 <Info min="0" flag="52" seq="1" ref="0" bb="2" group="116" />
               </Parameter>
-              <Parameter id="kwq8182UfECLtDP73JMNgQ" name="Reflection coefficient (large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_sigma_l" isDefault="1">
+              <Parameter id="CWM5sWcwoEKGBoyKzwOulw" name="Reflection coefficient (large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_sigma_l" isDefault="1">
                 <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                 <Info min="0" flag="58" seq="1" ref="0" bb="2" group="89" />
               </Parameter>
-              <Parameter id="fJmt_xPab0GTQyOPV_ReVg" name="Reflection coefficient (small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_sigma_s" isDefault="1">
+              <Parameter id="ox45xSd6ZEO4GoRCndl5KQ" name="Reflection coefficient (small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_sigma_s" isDefault="1">
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               </Parameter>
-              <Parameter id="mZ5Rop3a3E6ZsRJ1pnYhPQ" name="P (plasma&lt;-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial" isDefault="1" displayUnit="cm/min">
-                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="134" />
-              </Parameter>
             </Children>
           </Container>
-          <Parameter id="zQZxJh7sz0ObZg9OgnUT4g" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" isDefault="1" displayUnit="cm²">
+          <Parameter id="T9zRaZW_u0WMZi40arnyKg" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" isDefault="1" displayUnit="cm²">
             <Tags>
               <Tag value="Large intestine  neighborhood" />
               <Tag value="Neighborhood: Plasma / Interstitial" />
             </Tags>
             <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-            <Info min="0" flag="122" seq="28" ref="0" bb="32" group="106" />
+            <Info min="0" flag="122" seq="27" ref="0" bb="32" group="106" />
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       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="BiW_-qTBH0K_8FaDmmEY8g" name="Rectum_end_Rectum_ecl" mode="Logical" containerType="Neighborhood" firstNeighbor="sDh-svYJyEKCjXiZQWry0A" secondNeighbor="eDJJFajIZ0qqc5SSL9V05w">
+      <NeighborhoodBuilder id="FRaIWK4B3UyK93EY8woutg" name="Rectum_end_Rectum_ecl" mode="Logical" containerType="Neighborhood" firstNeighbor="dgS26q3Pd0iorPNFEOfBEg" secondNeighbor="0MjJnhA0s063jmqn9J-j4Q">
         <Tags>
           <Tag value="Large intestine  neighborhood" />
           <Tag value="Neighborhood: Endosome / EndosomalClearance" />
         </Tags>
         <Children>
-          <Container id="uio-rkGA6k-5DJyb57xT_g" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="cAvHLzs40EujMhMF0NWaNw" name="MoleculeProperties" mode="Logical" containerType="Other" />
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-      <NeighborhoodBuilder id="zK8Wp7R0VE2vmo6wB1kXWA" name="Rectum_end_Rectum_int" mode="Logical" containerType="Neighborhood" firstNeighbor="sDh-svYJyEKCjXiZQWry0A" secondNeighbor="jL0phy_0okq1f1ayx6hWMw">
+      <NeighborhoodBuilder id="0zqRSB77AEqJAJ-AKzmsEw" name="Rectum_end_Rectum_int" mode="Logical" containerType="Neighborhood" firstNeighbor="dgS26q3Pd0iorPNFEOfBEg" secondNeighbor="AuX8xqMG3UKUIJbe1_KPMg">
         <Tags>
           <Tag value="Large intestine  neighborhood" />
           <Tag value="Neighborhood: Endosome / Interstitial" />
         </Tags>
         <Children>
-          <Container id="ykChFEcuOUmDm99wu-5BDQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="FxTRgzBZ9UWFjW-h9DrDMg" name="MoleculeProperties" mode="Logical" containerType="Other" />
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-      <NeighborhoodBuilder id="1oGht_AaIkO4cg5z7unICw" name="Rectum_int_Rectum_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="jL0phy_0okq1f1ayx6hWMw" secondNeighbor="TOYzThEJtkuhn2I6SIg6tA">
+      <NeighborhoodBuilder id="_oRbievHOECI-pEyzxNTqA" name="Rectum_int_Rectum_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="AuX8xqMG3UKUIJbe1_KPMg" secondNeighbor="KYsx3k5GgUu-J_d7og6DPQ">
         <Tags>
           <Tag value="Large intestine  neighborhood" />
           <Tag value="Neighborhood: Interstitial / Intracellular" />
         </Tags>
         <Children>
-          <Container id="sQvlvNtBukiL1D-vwwjQ1w" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="xkUjT1_K_0GNJ5Yc9q9ZWQ" name="MoleculeProperties" mode="Logical" containerType="Other">
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-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+              <Parameter id="KNgeBPvEFE2rtjdL523i_w" name="P (interstitial-&gt;intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_int_cell_Mucosa" isDefault="1" displayUnit="cm/min">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="135" />
               </Parameter>
-              <Parameter id="devN0iOglEGboAeI5DeL_g" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+              <Parameter id="jmsI_1UR8ESu_6PflmRWBw" name="P (intracellular-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_cell_int_Mucosa" isDefault="1" displayUnit="cm/min">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="133" />
               </Parameter>
-              <Parameter id="0w8OHS_Qs0GmH2ehAqmWyQ" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
+              <Parameter id="ld6mun-H6Eiyen3Y7cQSAg" name="P*SA interstitial -&gt; intracellular" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" isDefault="1" displayUnit="l/min">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="k74q40_bkUuODrLQZ-bf6Q" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="147" />
-              </Parameter>
-              <Parameter id="TLY_ogODwUaK55dZWF2Oww" name="P (interstitial-&gt;intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_int_cell_Mucosa" isDefault="1" displayUnit="cm/min">
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="135" />
-              </Parameter>
-              <Parameter id="bxfucFy-ukugi-NuDmJjIw" name="P (intracellular-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_cell_int_Mucosa" isDefault="1" displayUnit="cm/min">
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="133" />
+              <Parameter id="Co3agLril0e0XtPPmU8ixg" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="FUgTyP42YE6vMomwIfC9kw" name="P*SA interstitial -&gt; intracellular" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" isDefault="1" displayUnit="l/min">
+              <Parameter id="jd-wxD-I60q1WNUJjh_oAg" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="JVoruNm39E6W42QLmYN-5g" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
+              <Parameter id="nkxxWVmLK0GpKiiawrLnww" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
+              <Parameter id="DfwBmDJET0aQRhlNnd-jfw" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="147" />
+              </Parameter>
+              <Parameter id="KbJwIawPYEWslnHthVDL5A" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+              </Parameter>
             </Children>
           </Container>
-          <Parameter id="O4VKcNuoR0S-iArCEMfqUA" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mucosa_rect" isDefault="1" displayUnit="cm²">
+          <Parameter id="KK164GznWE6QjXE1-NtIrg" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mucosa_rect" isDefault="1" displayUnit="cm²">
             <Tags>
               <Tag value="Large intestine  neighborhood" />
               <Tag value="Neighborhood: Interstitial / Intracellular" />
@@ -21761,14 +21775,14 @@
           </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="vQmvyvPD10qid_4ZDmJKGA" name="Rectum_pls_Rectum_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="Yd0rccV71UKsC54RMkELFQ" secondNeighbor="p0bnHVbUckaxiZF-DyaNeg">
+      <NeighborhoodBuilder id="kdqoYlxZJ0mboh5HxS7tsw" name="Rectum_pls_Rectum_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="8f8l-2PnRkC7BevNFjoHJw" secondNeighbor="Y-P-HpyhwkCHswnsdTF2gg">
         <Tags>
           <Tag value="Large intestine  neighborhood" />
           <Tag value="Neighborhood: Plasma / BloodCells" />
         </Tags>
         <Children>
-          <Container id="yxwZje_x5EuXJuUHov54yA" name="MoleculeProperties" mode="Logical" containerType="Other" />
-          <Parameter id="oBU1HEfCK0ixQkbdVo0P2w" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" isDefault="1" displayUnit="cm²">
+          <Container id="mmN1lWzHJEWpvADRsxaB-g" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Parameter id="8D8chvuU6kOwQNYgbwTSlg" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" isDefault="1" displayUnit="cm²">
             <Tags>
               <Tag value="Large intestine  neighborhood" />
               <Tag value="Neighborhood: Plasma / BloodCells" />
@@ -21777,432 +21791,556 @@
           </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="9KYpNhHXXU-njLIRyjyf8Q" name="Rectum_pls_Rectum_end" mode="Logical" containerType="Neighborhood" firstNeighbor="Yd0rccV71UKsC54RMkELFQ" secondNeighbor="sDh-svYJyEKCjXiZQWry0A">
+      <NeighborhoodBuilder id="5OhYOhhWF06LKYmkeIL3yg" name="Rectum_pls_Rectum_end" mode="Logical" containerType="Neighborhood" firstNeighbor="8f8l-2PnRkC7BevNFjoHJw" secondNeighbor="dgS26q3Pd0iorPNFEOfBEg">
         <Tags>
           <Tag value="Large intestine  neighborhood" />
           <Tag value="Neighborhood: Plasma / Endosome" />
         </Tags>
         <Children>
-          <Container id="w4XktUkcLUSOtu77dbPdEA" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="dC1qeWY2qU2SvQFmJaO24Q" name="MoleculeProperties" mode="Logical" containerType="Other" />
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="QibIob3Xm0qKMdkece3WAA" name="Rectum_pls_Rectum_int" mode="Logical" containerType="Neighborhood" firstNeighbor="8f8l-2PnRkC7BevNFjoHJw" secondNeighbor="AuX8xqMG3UKUIJbe1_KPMg">
+        <Tags>
+          <Tag value="Large intestine  neighborhood" />
+          <Tag value="Neighborhood: Plasma / Interstitial" />
+        </Tags>
+        <Children>
+          <Container id="qq0kZdsWPUeghR64eoOBdQ" name="MoleculeProperties" mode="Logical" containerType="Other">
+            <Children>
+              <Parameter id="WKuy1eLBQEiAQNKsjE0seA" name="P (large endothelial pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial_l" isDefault="1" displayUnit="cm/min">
+                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="79" />
+              </Parameter>
+              <Parameter id="-Kz9WSE_aEy1Yqh-3Ai_Aw" name="P (plasma&lt;-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial" isDefault="1" displayUnit="cm/min">
+                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="134" />
+              </Parameter>
+              <Parameter id="bGTSSmqncECnudHJ8RNgiA" name="P (small endothelial pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_2Poren.PARAM_P_endothelial_s" isDefault="1" displayUnit="cm/min">
+                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="80" />
+              </Parameter>
+              <Parameter id="CbdoYMAYbUWHio1o8Vq3cg" name="Partition coefficient (interstitial/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" isDefault="1">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="148" />
+              </Parameter>
+              <Parameter id="gPTSI1VFpEKo4C6dZ_oTJw" name="Peclet number (large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CalcPecletNumber.PecletNumber_l" isDefault="1">
+                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="116" />
+              </Parameter>
+              <Parameter id="DKNnri5MTEKMQV1X86lKQA" name="Peclet number (small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CalcPecletNumber.PecletNumber_s" isDefault="1">
+                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="116" />
+              </Parameter>
+              <Parameter id="scPPVLs0wEm52oMl4UH4Gw" name="Radius ratio (solute/large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_gamma_l" isDefault="1">
+                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="116" />
+              </Parameter>
+              <Parameter id="wqiMEtsNL0ad2LvYDrvRMQ" name="Radius ratio (solute/small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_gamma_s" isDefault="1">
+                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="116" />
+              </Parameter>
+              <Parameter id="UZZ19Axz_kyvwVXtNiMNdw" name="Reflection coefficient (large pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_sigma_l" isDefault="1">
+                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                <Info min="0" flag="58" seq="1" ref="0" bb="2" group="89" />
+              </Parameter>
+              <Parameter id="LTzAne1Xo0eMrm1Z5bygsw" name="Reflection coefficient (small pores)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TwoPoresGammaSigma.PARAM_sigma_s" isDefault="1">
+                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                <Info min="0" flag="58" seq="1" ref="0" bb="2" group="90" />
+              </Parameter>
+            </Children>
+          </Container>
+          <Parameter id="SlloEFS0d0u4NB9R_d83jg" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" isDefault="1" displayUnit="cm²">
+            <Tags>
+              <Tag value="Large intestine  neighborhood" />
+              <Tag value="Neighborhood: Plasma / Interstitial" />
+            </Tags>
+            <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+            <Info min="0" flag="122" seq="28" ref="0" bb="32" group="106" />
+          </Parameter>
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="MS4SxmiQS0yKRnD3IP067Q" name="ArterialBlood_bc_Bone_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="IhEBMJxutUm85iXU4_r5iQ" secondNeighbor="tJw6KPhGIEaErEmBaHPOEQ">
+        <Tags>
+          <Tag value="Neighborhood: BloodCells / BloodCells" />
+        </Tags>
+        <Children>
+          <Container id="A3gb5xmpSEazMsqaiTt7Yg" name="MoleculeProperties" mode="Logical" containerType="Other" />
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="7ofrk_9O6UixohcrfHHP7g" name="ArterialBlood_bc_Brain_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="IhEBMJxutUm85iXU4_r5iQ" secondNeighbor="FzwVGKYCd0-Uc9UyHkA0hQ">
+        <Tags>
+          <Tag value="Neighborhood: BloodCells / BloodCells" />
+        </Tags>
+        <Children>
+          <Container id="Pp0qmDfLT0qrSGw0g2Zrag" name="MoleculeProperties" mode="Logical" containerType="Other" />
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="6Pp1U4i77EetoUY_v47s_A" name="ArterialBlood_bc_Fat_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="IhEBMJxutUm85iXU4_r5iQ" secondNeighbor="YYBXz19EnU6njErj_BuzIw">
+        <Tags>
+          <Tag value="Neighborhood: BloodCells / BloodCells" />
+        </Tags>
+        <Children>
+          <Container id="UjK1J1X430SV5X4RbPARWg" name="MoleculeProperties" mode="Logical" containerType="Other" />
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="zWjhE7e8SU2UE3k_HCge_g" name="ArterialBlood_bc_Gonads_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="IhEBMJxutUm85iXU4_r5iQ" secondNeighbor="OrkfbCRtxUuetJtuFM-A0Q">
+        <Tags>
+          <Tag value="Neighborhood: BloodCells / BloodCells" />
+        </Tags>
+        <Children>
+          <Container id="VAB23r5z2EK_M4Lwh2HEcg" name="MoleculeProperties" mode="Logical" containerType="Other" />
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="T1CMqnzTdEmfqCqUDRPEVg" name="ArterialBlood_bc_Heart_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="IhEBMJxutUm85iXU4_r5iQ" secondNeighbor="5ipnQqMXH02UkoNY4MBfnQ">
+        <Tags>
+          <Tag value="Neighborhood: BloodCells / BloodCells" />
+        </Tags>
+        <Children>
+          <Container id="iY6RItJjIUOKVPGOMlsG8A" name="MoleculeProperties" mode="Logical" containerType="Other" />
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="naRLYN8PXkuakcOPRDgy-g" name="ArterialBlood_bc_Kidney_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="IhEBMJxutUm85iXU4_r5iQ" secondNeighbor="U7McxF7HlEmM8C7PIYjgWQ">
+        <Tags>
+          <Tag value="Neighborhood: BloodCells / BloodCells" />
+        </Tags>
+        <Children>
+          <Container id="tx8xaRDwLUKbXnrqQxUdtQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="wR3CB6MOc0qKO6GMz_q7wA" name="ArterialBlood_bc_LargeIntestine_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="IhEBMJxutUm85iXU4_r5iQ" secondNeighbor="ndxtR_Omb0-tlAGFCBQMeg">
+        <Tags>
+          <Tag value="Neighborhood: BloodCells / BloodCells" />
+        </Tags>
+        <Children>
+          <Container id="jLE2_G3m90yadjTnVTWvBg" name="MoleculeProperties" mode="Logical" containerType="Other" />
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="wXTbc3I6wkK7c7MydbdWSQ" name="ArterialBlood_bc_Muscle_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="IhEBMJxutUm85iXU4_r5iQ" secondNeighbor="kD3oluKAvkyAZrqeM4x7lg">
+        <Tags>
+          <Tag value="Neighborhood: BloodCells / BloodCells" />
+        </Tags>
+        <Children>
+          <Container id="hzurZocd1ECNgGcUgDFfvg" name="MoleculeProperties" mode="Logical" containerType="Other" />
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="eo3zudN6aEKtMetiWsjcVQ" name="ArterialBlood_bc_Pancreas_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="IhEBMJxutUm85iXU4_r5iQ" secondNeighbor="l1XrGlW2T0imgmV2b6Ugyw">
+        <Tags>
+          <Tag value="Neighborhood: BloodCells / BloodCells" />
+        </Tags>
+        <Children>
+          <Container id="Aj4EHK76EUu76Nv6O6De-Q" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="tA2AvtEAykyUuJeF_o1Onw" name="ArterialBlood_pls_SmallIntestine_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="4825D6NCvEaDod9eLrQ1OQ" secondNeighbor="7_ch4FUOPEyotM_fc9eLow">
+      <NeighborhoodBuilder id="PdSwg4t-qkmJr2sRksvQRQ" name="ArterialBlood_bc_Skin_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="IhEBMJxutUm85iXU4_r5iQ" secondNeighbor="8ItszmLwQEa_HitvX4V2Uw">
+        <Tags>
+          <Tag value="Neighborhood: BloodCells / BloodCells" />
+        </Tags>
+        <Children>
+          <Container id="1DuE1rmCa0afpRLJbQKCmw" name="MoleculeProperties" mode="Logical" containerType="Other" />
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="PVkRxxn1YUSDxOnzCfw9TQ" name="ArterialBlood_bc_SmallIntestine_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="IhEBMJxutUm85iXU4_r5iQ" secondNeighbor="vXL46mJIE0uG18PXFjzX5g">
+        <Tags>
+          <Tag value="Neighborhood: BloodCells / BloodCells" />
+        </Tags>
+        <Children>
+          <Container id="edVFOMG6dEacsuTNef5taQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="v5TrW4SqgkmqoMbJqHcVpw" name="ArterialBlood_bc_Spleen_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="IhEBMJxutUm85iXU4_r5iQ" secondNeighbor="L_KVwSudLEGk42Q8mLUZ1Q">
+        <Tags>
+          <Tag value="Neighborhood: BloodCells / BloodCells" />
+        </Tags>
+        <Children>
+          <Container id="zp5kOiQOn0y1VARzk2Aysg" name="MoleculeProperties" mode="Logical" containerType="Other" />
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="r405KBzPf0CU-ZELCbuVwg" name="ArterialBlood_bc_Stomach_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="IhEBMJxutUm85iXU4_r5iQ" secondNeighbor="r-N8X-cLkE-cKfvE0t6EKQ">
+        <Tags>
+          <Tag value="Neighborhood: BloodCells / BloodCells" />
+        </Tags>
+        <Children>
+          <Container id="Tiw7OzTYYk685UPNmGK2Hw" name="MoleculeProperties" mode="Logical" containerType="Other" />
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="lCyr12CbxUWPAh33eTQwVg" name="ArterialBlood_pls_Bone_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="8w_HEBIvlUCHJDlw_MvzWw" secondNeighbor="fusuTlSi4kCVIX7JKRrMwg">
         <Tags>
           <Tag value="Neighborhood: Plasma / Plasma" />
         </Tags>
         <Children>
-          <Container id="KlGMI7Dfh0KbIaMJXznK-w" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="JvaMW474QUOfudxdzAH4kg" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="MFDx-Du7g0aa62MdQ4h6rA" name="ArterialBlood_pls_Spleen_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="4825D6NCvEaDod9eLrQ1OQ" secondNeighbor="9Fe1IZB_tEKPcqvJAmybMA">
+      <NeighborhoodBuilder id="PnN7E_bHDEOiGZA4AY_rHg" name="ArterialBlood_pls_Brain_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="8w_HEBIvlUCHJDlw_MvzWw" secondNeighbor="B3ppcgqIdE6xO8qFxNT7fw">
         <Tags>
           <Tag value="Neighborhood: Plasma / Plasma" />
         </Tags>
         <Children>
-          <Container id="iYNbv9r9iEKMgb_TyvJIFA" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="p0DqSP_9F0-MHuXjYlQIAw" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="w2OuFoLi_U6KSOECk3iVXQ" name="ArterialBlood_pls_Stomach_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="4825D6NCvEaDod9eLrQ1OQ" secondNeighbor="T-c_8D2_o0S5jdeWnl0JhA">
+      <NeighborhoodBuilder id="UK1C8w5DjkGHvx0vpb7PSg" name="ArterialBlood_pls_Fat_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="8w_HEBIvlUCHJDlw_MvzWw" secondNeighbor="C5HmC00ryECjS1x2r0r1xw">
         <Tags>
           <Tag value="Neighborhood: Plasma / Plasma" />
         </Tags>
         <Children>
-          <Container id="FrBtUTJae0qlSwWT4tDacw" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="UWpJ6KzFq0qvzuCMn2mzvg" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="2LhlqnFj4EiGfeExlGPtSg" name="Lumen_duo_Duodenum_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="Soy8bWRBA0aKD_xjTO8QdQ" secondNeighbor="n53695myoESMtqbFy_q0Ww">
+      <NeighborhoodBuilder id="niIebNGEtku4xJL30fHYYg" name="ArterialBlood_pls_Gonads_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="8w_HEBIvlUCHJDlw_MvzWw" secondNeighbor="df0Tdp64lk2CyQa_SXJyIA">
         <Tags>
-          <Tag value="Neighborhood: Duodenum / Intracellular" />
+          <Tag value="Neighborhood: Plasma / Plasma" />
         </Tags>
         <Children>
-          <Container id="9tDlahTLZUGcxiIFrulnyw" name="MoleculeProperties" mode="Logical" containerType="Other">
-            <Children>
-              <Parameter id="FvPmn5V88kabQMJoz6yGZw" name="pKa_pH_WS_cell_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K7" isDefault="1">
-                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
-              </Parameter>
-              <Parameter id="w3eFptgKm0iQvHu_cO4hDQ" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_Duodenum" isDefault="1">
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
-              </Parameter>
-              <Parameter id="KdjKrtFoekmJqd1toAgj9g" name="pKa_pH_WS_cell_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F1" isDefault="1">
-                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
-              </Parameter>
-              <Parameter id="ZSPyTK6HNUi5AfBZs2MSXA" name="pKa_pH_WS_cell_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F2" isDefault="1">
-                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
-              </Parameter>
-              <Parameter id="-Y9nGKfeRkK52wVC7F5bZQ" name="pKa_pH_WS_cell_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F3" isDefault="1">
-                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
-              </Parameter>
-              <Parameter id="x3KVXfozPEuj0VLv8_wzsw" name="pKa_pH_WS_cell_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K1" isDefault="1">
-                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
-              </Parameter>
-              <Parameter id="Q3FqPLAHFkursQyPYWNM3A" name="pKa_pH_WS_cell_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K2" isDefault="1">
-                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
-              </Parameter>
-              <Parameter id="HC4wfhHUokS3kXlY4TFUiQ" name="pKa_pH_WS_cell_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K3" isDefault="1">
-                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
-              </Parameter>
-              <Parameter id="Vv5_0JzhGEqSbe3Abt-6Gg" name="pKa_pH_WS_cell_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K4" isDefault="1">
-                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
-              </Parameter>
-              <Parameter id="2vioAQ8DEk-xIJPp71-1Pw" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K5" isDefault="1">
-                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
-              </Parameter>
-              <Parameter id="1r0WtOY5yUKNWL8X31E8Cg" name="pKa_pH_WS_cell_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K6" isDefault="1">
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-              </Parameter>
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-              </Parameter>
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-                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
-              </Parameter>
-            </Children>
-          </Container>
+          <Container id="6KDZWXLf00qrR2qTwPEW9Q" name="MoleculeProperties" mode="Logical" containerType="Other" />
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-      <NeighborhoodBuilder id="FfszVLOzHkuyKCASBwJTMQ" name="ArterialBlood_pls_Kidney_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="4825D6NCvEaDod9eLrQ1OQ" secondNeighbor="uvY_1LLgFkmC19hgQgPOrA">
+      <NeighborhoodBuilder id="RuUHKz3Zy0uDAX1ZXfK4eg" name="ArterialBlood_pls_Heart_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="8w_HEBIvlUCHJDlw_MvzWw" secondNeighbor="BPlJ6mgA6EK5m9A3L5pXww">
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           <Tag value="Neighborhood: Plasma / Plasma" />
         </Tags>
         <Children>
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+          <Container id="GQrAr1fzQUa_cswI6XIP9g" name="MoleculeProperties" mode="Logical" containerType="Other" />
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+      <NeighborhoodBuilder id="CUBIt-N1AEuMIC9izUrmsA" name="ArterialBlood_pls_Kidney_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="8w_HEBIvlUCHJDlw_MvzWw" secondNeighbor="AErFqOgHOE2YxQBOP5vPBA">
         <Tags>
-          <Tag value="Neighborhood: Duodenum / Plasma" />
+          <Tag value="Neighborhood: Plasma / Plasma" />
         </Tags>
         <Children>
-          <Container id="6dv746oUW0-W60rAVLhnnw" name="MoleculeProperties" mode="Logical" containerType="Other">
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-                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
-              </Parameter>
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-                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
-              </Parameter>
-            </Children>
-          </Container>
+          <Container id="pLJ_rV8_bke1wdYuebGkvg" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="Gxkt-kNmZUWbcl-mZAsyXA" name="ArterialBlood_pls_Fat_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="4825D6NCvEaDod9eLrQ1OQ" secondNeighbor="kr-PEFddzEibScWFXl8A1Q">
+      <NeighborhoodBuilder id="PVHEmsCvZE2c-ouJ4Up9vQ" name="ArterialBlood_pls_LargeIntestine_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="8w_HEBIvlUCHJDlw_MvzWw" secondNeighbor="RNkPLFnn1Eepynm3sVKH1g">
         <Tags>
           <Tag value="Neighborhood: Plasma / Plasma" />
         </Tags>
         <Children>
-          <Container id="DFEXkkypWECc3IR-U0554w" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="JXNgUQwCVUyfyi_yWgW1aw" name="MoleculeProperties" mode="Logical" containerType="Other" />
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       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="iG88H_MCikSsPF0PwOfpJQ" name="ArterialBlood_pls_Gonads_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="4825D6NCvEaDod9eLrQ1OQ" secondNeighbor="fp9hd7IFYU2_YcZqajTbVw">
+      <NeighborhoodBuilder id="SimKw8JjckCqt05DVI006g" name="ArterialBlood_pls_Muscle_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="8w_HEBIvlUCHJDlw_MvzWw" secondNeighbor="J6TvTdzQc0qHhjOUV7HN2A">
         <Tags>
           <Tag value="Neighborhood: Plasma / Plasma" />
         </Tags>
         <Children>
-          <Container id="4qi4DEqLQUmzSjtcGhMAKg" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="xVDN-f3LfUmCU_Vt_3AzpA" name="MoleculeProperties" mode="Logical" containerType="Other" />
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       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="qrPnA883R0qYsz67Bfkgow" name="ArterialBlood_pls_Heart_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="4825D6NCvEaDod9eLrQ1OQ" secondNeighbor="8_Mn7V4mf0aieii5LhKrpQ">
+      <NeighborhoodBuilder id="XQyimxndkEC6JyouU9KHVQ" name="ArterialBlood_pls_Pancreas_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="8w_HEBIvlUCHJDlw_MvzWw" secondNeighbor="YsbwAOG-BEmsvMbXYCnGFA">
         <Tags>
           <Tag value="Neighborhood: Plasma / Plasma" />
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         <Children>
-          <Container id="5-st6aq_00KhgdC0xiTn2g" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="Lnv7PonGWU6GZC65sEl1lg" name="MoleculeProperties" mode="Logical" containerType="Other" />
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       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="Bb_FCrg-QE6j041FfnqVmw" name="ArterialBlood_pls_Muscle_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="4825D6NCvEaDod9eLrQ1OQ" secondNeighbor="l51KslyykkOxfiw6tYx29Q">
+      <NeighborhoodBuilder id="IiprK6d-kEWLNJyYlddSeg" name="ArterialBlood_pls_Skin_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="8w_HEBIvlUCHJDlw_MvzWw" secondNeighbor="1O7Xx6qzDEKO8BkNiCdrgQ">
         <Tags>
           <Tag value="Neighborhood: Plasma / Plasma" />
         </Tags>
         <Children>
-          <Container id="_hQuQCLon0muIOHrP1T0-Q" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="4roUXrqQ0EGntlZKUggBEg" name="MoleculeProperties" mode="Logical" containerType="Other" />
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       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="Cy7CBgFRzkeCgOL6WuQYPA" name="ArterialBlood_pls_Skin_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="4825D6NCvEaDod9eLrQ1OQ" secondNeighbor="XqtoJLmkfUuYtaf2I2jTlg">
+      <NeighborhoodBuilder id="WHXwg_ETeUm4CJPAzDu-Cg" name="ArterialBlood_pls_SmallIntestine_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="8w_HEBIvlUCHJDlw_MvzWw" secondNeighbor="Bswuw2JsQ0muIVZwkoC_bA">
         <Tags>
           <Tag value="Neighborhood: Plasma / Plasma" />
         </Tags>
         <Children>
-          <Container id="PNqowNjHu0mmRvnNwYLoPQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="PU_8iZWB1k6g7B7zZ-Cs9Q" name="MoleculeProperties" mode="Logical" containerType="Other" />
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       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="ixMeTlDFLEWxk55F2YF6bg" name="ArterialBlood_pls_LargeIntestine_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="4825D6NCvEaDod9eLrQ1OQ" secondNeighbor="G9LknYNSJ0CqRovE2-2YJg">
+      <NeighborhoodBuilder id="rim0SHdyg0Sw_idFvNw5Fg" name="ArterialBlood_pls_Spleen_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="8w_HEBIvlUCHJDlw_MvzWw" secondNeighbor="jkTc5JbBPkGr-ZHYsEDFfg">
         <Tags>
           <Tag value="Neighborhood: Plasma / Plasma" />
         </Tags>
         <Children>
-          <Container id="NIOOFM0VtkiGu_itwIlT6A" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="FkIiERu9u0K-Gr_neKUc9Q" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="C9h7ybdXlUWGwBzG43_IMw" name="ArterialBlood_pls_Pancreas_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="4825D6NCvEaDod9eLrQ1OQ" secondNeighbor="EWh-xn7PUUmE9uA8-XEpMw">
+      <NeighborhoodBuilder id="RsLRF3Wxb06eHkbVuxjibA" name="ArterialBlood_pls_Stomach_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="8w_HEBIvlUCHJDlw_MvzWw" secondNeighbor="1Y1b2vLN9kKD2bFVFJvlPA">
         <Tags>
           <Tag value="Neighborhood: Plasma / Plasma" />
         </Tags>
         <Children>
-          <Container id="I5PbqxutXUmj2jPrgB_RtA" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="QKYhzZpNmk-toZDsqSt7ag" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="q-Ql74RESUm1_NQCV3IrCA" name="ColonSigmoid_bc_PortalVein_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="YAV9FvgIukGma6WLTJdmAQ" secondNeighbor="oz2_zRPfzk-ZhQqUyIQ6kg">
+      <NeighborhoodBuilder id="ji5WkAsiY0KZuOWZbDSDHQ" name="Lumen_duo_Duodenum_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="Q2OaqR8Xk0-oRedeXkkAcA" secondNeighbor="0kFKBI9cUEeUTIqKlJNFrg">
         <Tags>
-          <Tag value="Neighborhood: BloodCells / BloodCells" />
+          <Tag value="Neighborhood: Duodenum / Plasma" />
         </Tags>
         <Children>
-          <Container id="uiCXkJ6Q_EmUEh_zQ7cdRA" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="qSIK1B_7LUOQ8t6Ur8-VjA" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="13CIGixNA0S01gj8ityOTQ" name="Mass transfer rate (mucosa to portal vein blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_forTwoPores.PARAM_MassTransferMucosaToPveBloodCells" isDefault="1" displayUnit="µmol/min">
-                <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+              <Parameter id="Jpl8V5NjH0W1WJlpjdIexg" name="Drug absorption rate (lumen to mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_DrugAbsorption_para" isDefault="1" displayUnit="µmol/min">
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+              </Parameter>
+              <Parameter id="nJJ6x8mRA02FYIqhsjVBgA" name="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" isDefault="1" displayUnit="µmol/min">
+                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
+              <Parameter id="dTEHmkwzkUG_lSwT5poVGw" name="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" isDefault="1" displayUnit="µmol/min">
+                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
+            </Children>
+          </Container>
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="kQK6F7xeQky_-oePfKe9QA" name="Lumen_duo_Duodenum_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="Q2OaqR8Xk0-oRedeXkkAcA" secondNeighbor="gWunQQ0CDk63u-YyP8U4Tw">
+        <Tags>
+          <Tag value="Neighborhood: Duodenum / Intracellular" />
+        </Tags>
+        <Children>
+          <Container id="kDOUle_Udk2fGVS-oK8NGQ" name="MoleculeProperties" mode="Logical" containerType="Other">
+            <Children>
+              <Parameter id="dEJ70GEeN0-EB1AATdVChA" name="Drug absorption rate (lumen to mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_DrugAbsorption_trans" isDefault="1" displayUnit="µmol/min">
                 <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
               </Parameter>
+              <Parameter id="nKNYe4stKUuhcCMEygapVg" name="P_int_trans_cell_lum_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_cell_lum_factor" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="pGHL5VvJN0qdeJGET83nDQ" name="P_int_trans_lum_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_lum_cell_factor" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="hA4atKWMrUCJ_og518jEPA" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_K_cell_pls_Duodenum" isDefault="1">
+                <Info min="0" flag="36" seq="1" ref="0" bb="2" group="67" />
+              </Parameter>
+              <Parameter id="vAf53ygVwkm7kt6BqUFxpw" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_Duodenum" isDefault="1">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+              </Parameter>
+              <Parameter id="5MeXVGSbsk-RwVRwJ572Dg" name="pKa_pH_WS_cell_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F1" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="0-Jc9SpkPEq7AZq0yBMmmA" name="pKa_pH_WS_cell_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F2" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="vYZ4YYwNJ0-gaSBAA245xQ" name="pKa_pH_WS_cell_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F3" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="_kD7YaOvp0Kb3dnYHu4zpg" name="pKa_pH_WS_cell_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K1" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="MltBGoN1dkKckaQNbfZknQ" name="pKa_pH_WS_cell_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K2" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="tLhXp1toyEuJXyLujYKAvw" name="pKa_pH_WS_cell_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K3" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="UPJEwcOPlEm67FFBDHVxoQ" name="pKa_pH_WS_cell_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K4" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="R1KWXnCouUuymu91GvCB3w" name="pKa_pH_WS_cell_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K5" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="P_KpsX1iAkOHYKwkfGfxew" name="pKa_pH_WS_cell_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K6" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="fbZAgYA9Jki7ChQwri1r_Q" name="pKa_pH_WS_cell_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K7" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="ISL4C6yQTUiUXtgUhHp8Gg" name="pKa_pH_WS_cell_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K8" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="ikdLPScGNE2GlU3Lalf8tw" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F1" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="WVUoNyGmyka0fuQAamxpvQ" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F2" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="8ZLGBUASXk2FSnHOtevXcA" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F3" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="YNf1nVbOKU-Dwz7cTRkHmg" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K1" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="ZiDB7GEzhkSS6Km9H8_Ykw" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K2" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="A1aPma5u1ka7f7SgJZoJMA" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K3" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="XKRuuqQYQUq2lr3Arg6aBg" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K4" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="VYz36fnq90G3joVxymcU3A" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K5" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="R0g_t9OMBE2Gv3EEpUZu1Q" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K6" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="EUGI17_rXUOg_UYwEjbxWg" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K7" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="2OkY0RIeOEGSpbJWrv03Ew" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K8" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="oOMsIrmzTU2hMEs6gxHJWQ" name="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" isDefault="1" displayUnit="µmol/min">
+                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
+              <Parameter id="-dpDynStjESgfy3sdxnpaw" name="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" isDefault="1" displayUnit="µmol/min">
+                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
             </Children>
           </Container>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="Qo-K2GvPwkSJS9ITAEa0Tg" name="Lumen_colsigm_ColonSigmoid_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="B12kRDWtqUGL5miHA0Saxg" secondNeighbor="wK5jXxrXl0-zE0K0MBqJ2g">
+      <NeighborhoodBuilder id="P7tCDmYtNEK_dqwiG8nLig" name="Duodenum_pls_PortalVein_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="0kFKBI9cUEeUTIqKlJNFrg" secondNeighbor="d626iVqs-ESin5Db2bAqWg">
         <Tags>
-          <Tag value="Neighborhood: ColonSigmoid / Plasma" />
+          <Tag value="Neighborhood: Plasma / Plasma" />
         </Tags>
         <Children>
-          <Container id="U-xskQWdQ0SHDC2IW0rIQw" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="xuadVZo0zkCSJ2MEGicOhQ" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="WOTA_6TK-ECds2nyDDU1QQ" name="Drug absorption rate (lumen to mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_DrugAbsorption_para" isDefault="1" displayUnit="µmol/min">
+              <Parameter id="50JIDv6CuEGFfxSOZg7jFw" name="Mass transfer rate (mucosa to portal vein plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_forTwoPores.PARAM_MassTransferMucosaToPvePlasma" isDefault="1" displayUnit="µmol/min">
+                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                 <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
               </Parameter>
-              <Parameter id="fCntdRezvE-GZvYx5gpcHQ" name="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" isDefault="1" displayUnit="µmol/min">
-                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
-              </Parameter>
-              <Parameter id="ea2hzXwbbk2-9ofoZ5A_ow" name="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" isDefault="1" displayUnit="µmol/min">
-                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
-              </Parameter>
             </Children>
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         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="v684PUVuXk6cW63QfD94ww" name="ColonSigmoid_pls_PortalVein_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="wK5jXxrXl0-zE0K0MBqJ2g" secondNeighbor="5TpyW0Sd9USQGXc2frzUgA">
+      <NeighborhoodBuilder id="rKqxhoCDh0ittcsbc1b1Gg" name="Duodenum_bc_PortalVein_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="2WfG5NZzVUWJFhsQUD4L5w" secondNeighbor="J7qhrNHWA0i3ePh_JHm2LQ">
         <Tags>
-          <Tag value="Neighborhood: Plasma / Plasma" />
+          <Tag value="Neighborhood: BloodCells / BloodCells" />
         </Tags>
         <Children>
-          <Container id="4pdvj11i10O-OXN2PfeOUw" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="YOaTINszh0eCGso_Hp9-sA" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="L5gODYPgQ0S8Ynb-9fxlMQ" name="Mass transfer rate (mucosa to portal vein plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_forTwoPores.PARAM_MassTransferMucosaToPvePlasma" isDefault="1" displayUnit="µmol/min">
-                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+              <Parameter id="Bqu4Q76eIEefBhtIUbH4Aw" name="Mass transfer rate (mucosa to portal vein blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_forTwoPores.PARAM_MassTransferMucosaToPveBloodCells" isDefault="1" displayUnit="µmol/min">
+                <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                 <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
               </Parameter>
             </Children>
           </Container>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="HyZRI-xWtk2-2awMwCk4tA" name="Lumen_cae_Caecum_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="g73FHixAbke8T8DjmH5heQ" secondNeighbor="PdIK1tifAUOH4joR3xeI0A">
+      <NeighborhoodBuilder id="yeB03iFoMkWJLmXp3jzenA" name="Lumen_cae_Caecum_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="YtQbk7tJX0SRGBH7l7Mvow" secondNeighbor="6rbF-W8rIUq5hZ8odtvzrQ">
         <Tags>
           <Tag value="Neighborhood: Caecum / Plasma" />
         </Tags>
         <Children>
-          <Container id="IL0gEEug1kSPNr6xn5xlVA" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="8birQT5prUS03VA_QHlmtg" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="BLMc__IrAkOMVrIHVFlkNA" name="Drug absorption rate (lumen to mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_DrugAbsorption_para" isDefault="1" displayUnit="µmol/min">
+              <Parameter id="O7p_jtoq9kaCCUgOeFTwDw" name="Drug absorption rate (lumen to mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_DrugAbsorption_para" isDefault="1" displayUnit="µmol/min">
                 <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
               </Parameter>
-              <Parameter id="qpii2AsmD02JC_n3a9rAlw" name="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" isDefault="1" displayUnit="µmol/min">
+              <Parameter id="tb78DeONiEizW2j4BaG5CA" name="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" isDefault="1" displayUnit="µmol/min">
                 <Info flag="52" seq="1" ref="0" bb="2" group="117" />
               </Parameter>
-              <Parameter id="YpKOeHlHC0apKdU9YuVNUw" name="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" isDefault="1" displayUnit="µmol/min">
+              <Parameter id="E-hNM-BMPE-RclOxQKcffw" name="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" isDefault="1" displayUnit="µmol/min">
                 <Info flag="52" seq="1" ref="0" bb="2" group="117" />
               </Parameter>
             </Children>
           </Container>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="JnH3ZaDHAUC3b4lWlImSdw" name="Lumen_cae_Caecum_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="g73FHixAbke8T8DjmH5heQ" secondNeighbor="1YH-god92USKlp7JoWKh7g">
+      <NeighborhoodBuilder id="mIJo1Nxg5EKEHZppTohTfg" name="Lumen_cae_Caecum_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="YtQbk7tJX0SRGBH7l7Mvow" secondNeighbor="AxF00LW0V0eNOPUgpupvmQ">
         <Tags>
           <Tag value="Neighborhood: Caecum / Intracellular" />
         </Tags>
         <Children>
-          <Container id="I5AXcLVSIEung57mqTXfAQ" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="bR1eBu7MxEGSzLjCaAcSaQ" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="lqwoosPAZke5F25PZ67HCw" name="Drug absorption rate (lumen to mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_DrugAbsorption_trans" isDefault="1" displayUnit="µmol/min">
+              <Parameter id="4Kl8wRtxjUSMIQxif0Z7tA" name="Drug absorption rate (lumen to mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_DrugAbsorption_trans" isDefault="1" displayUnit="µmol/min">
                 <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
               </Parameter>
-              <Parameter id="sv5V8xqqL0SXnYgywkZjrg" name="P_int_trans_cell_lum_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_cell_lum_factor" isDefault="1">
+              <Parameter id="xg8RTbeJ1kqfLIWxYsfeAA" name="P_int_trans_cell_lum_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_cell_lum_factor" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="_dMNVYs06UW2G1CjnlISsQ" name="P_int_trans_lum_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_lum_cell_factor" isDefault="1">
+              <Parameter id="Zsx28yByYEO0xjiGIDgUuA" name="P_int_trans_lum_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_lum_cell_factor" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="hetKQ0L4IUimXUgE3WjClw" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_K_cell_pls_Caecum" isDefault="1">
+              <Parameter id="eLalulRN6kSXoN06IM93aw" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_K_cell_pls_Caecum" isDefault="1">
                 <Info min="0" flag="36" seq="1" ref="0" bb="2" group="67" />
               </Parameter>
-              <Parameter id="PF42ENew306US5quCUEGIg" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_Caecum" isDefault="1">
+              <Parameter id="ir7kUc4gRkKJvd_1Ds6qxQ" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_Caecum" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
               </Parameter>
-              <Parameter id="sQ40pNdnvEuiupLvfl1glg" name="pKa_pH_WS_cell_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F3" isDefault="1">
+              <Parameter id="WV2nBOzt6ECTB7wTy5NPwg" name="pKa_pH_WS_cell_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F1" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="mmS6yNB75Ei6-XKBJEYN0A" name="pKa_pH_WS_cell_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F1" isDefault="1">
+              <Parameter id="LqgQCrQoEUu4zD8fgyR5tA" name="pKa_pH_WS_cell_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F2" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="-pj5xUQuQEyKHrOWQuZmwQ" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K2" isDefault="1">
+              <Parameter id="O4AqLJ6TBkKvQRTRqRpFdw" name="pKa_pH_WS_cell_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F3" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
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+              <Parameter id="ueKb6585zUutXb2rfX_E_g" name="pKa_pH_WS_cell_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K1" isDefault="1">
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               </Parameter>
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+              <Parameter id="OqYdWW_Ru06pyb_YTnTFXg" name="pKa_pH_WS_cell_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K2" isDefault="1">
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               </Parameter>
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+              <Parameter id="aFSLhqx5wUWwqYfUgCCRtg" name="pKa_pH_WS_cell_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K3" isDefault="1">
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               </Parameter>
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+              <Parameter id="FiXRtQ7tNk2FgGxFZbKEYg" name="pKa_pH_WS_cell_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K4" isDefault="1">
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               </Parameter>
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+              <Parameter id="6bDkJJoLKUOXg4JUH6wc8g" name="pKa_pH_WS_cell_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K5" isDefault="1">
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               </Parameter>
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+              <Parameter id="2HSrI_flbkmxeKL7e71TEQ" name="pKa_pH_WS_cell_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K6" isDefault="1">
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               </Parameter>
-              <Parameter id="pvWOgzQt1Uy4I9AmM5sHZQ" name="pKa_pH_WS_cell_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K7" isDefault="1">
+              <Parameter id="dWS9KgfEWk2m3Uoch3TuXQ" name="pKa_pH_WS_cell_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K7" isDefault="1">
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               </Parameter>
-              <Parameter id="9TmKX-n45EmdVN01Y6dwuA" name="pKa_pH_WS_cell_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K8" isDefault="1">
+              <Parameter id="tTuDsJKbi0yyBStwjb_eNQ" name="pKa_pH_WS_cell_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K8" isDefault="1">
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               </Parameter>
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+              <Parameter id="TmL3qobe7EK3rucaVdWnUQ" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F1" isDefault="1">
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               </Parameter>
-              <Parameter id="pEYprV4hjU--muZMtwqspA" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F2" isDefault="1">
+              <Parameter id="MlmBEAgYAUib45P0VvFK7w" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F2" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="KiNSO6Zf0USdSt_wE-SmuA" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K1" isDefault="1">
+              <Parameter id="lmicVQnn8UWbDOPHe-jPIw" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F3" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="H4TDDKqaFEOBI6IqDd3dPQ" name="pKa_pH_WS_cell_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F2" isDefault="1">
+              <Parameter id="RYtO5yGvXE26JRek8rXFeA" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K1" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="yi2VdP8ksUG-u4-Eehcu5g" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K3" isDefault="1">
+              <Parameter id="5-x2F2mh8EqZrqhXIqCnbg" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K2" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="tHz1uo20tEW9afpYWBRDDA" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K4" isDefault="1">
+              <Parameter id="Pl4gwbJ4wUyqGOApnnjMog" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K3" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="_cq3_WBofkuTFH0SEnzZiA" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K5" isDefault="1">
+              <Parameter id="4vj3j8at3UiqAak8Ja2aaw" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K4" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="NYryH-1zuEW8zoF6iiO2vA" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K6" isDefault="1">
+              <Parameter id="DTFMDC0VoUKj8-3IO2eOUw" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K5" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="Zvv6J3dGBkiGntYGgpBIug" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K7" isDefault="1">
+              <Parameter id="LFdGfb77okCfmWm3A54SPQ" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K6" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="JskjDiPi-E-old3W5RA3lg" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K8" isDefault="1">
+              <Parameter id="-Jum4-Hmj0GRA8R7T4q8Xg" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K7" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="4v5Jc4-LkE-OPXF8FwEo7A" name="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" isDefault="1" displayUnit="µmol/min">
-                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
-              </Parameter>
-              <Parameter id="2C39FrHYlUiQfyVkUVTKig" name="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" isDefault="1" displayUnit="µmol/min">
-                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
-              </Parameter>
-              <Parameter id="BRuBs-m6CU6XKLWUudREBQ" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F3" isDefault="1">
+              <Parameter id="bdUTl8N9y0iODQX1ZeVUzQ" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K8" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
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-          </Container>
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-      </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="0PmT_G_bd0eU6KUDvaXCEw" name="Duodenum_bc_PortalVein_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="saXE0Q67yUSDrhlQv5I4-A" secondNeighbor="oz2_zRPfzk-ZhQqUyIQ6kg">
-        <Tags>
-          <Tag value="Neighborhood: BloodCells / BloodCells" />
-        </Tags>
-        <Children>
-          <Container id="jvvd6oty4kmhffo0wOLJzA" name="MoleculeProperties" mode="Logical" containerType="Other">
-            <Children>
-              <Parameter id="VOlQEdODOkem-AqxEqbzlA" name="Mass transfer rate (mucosa to portal vein blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_forTwoPores.PARAM_MassTransferMucosaToPveBloodCells" isDefault="1" displayUnit="µmol/min">
-                <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
-                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
-              </Parameter>
-            </Children>
-          </Container>
-        </Children>
-      </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="7BT0bPsuREaQ3HNAo8-QSA" name="Lumen_coltrans_ColonTransversum_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="ie3h9CgxCU284p0wLjL9fw" secondNeighbor="1FuSD0o0hEa4L3rGx4i7HA">
-        <Tags>
-          <Tag value="Neighborhood: ColonTransversum / Plasma" />
-        </Tags>
-        <Children>
-          <Container id="RP27DIosokq0EUrHp6itfg" name="MoleculeProperties" mode="Logical" containerType="Other">
-            <Children>
-              <Parameter id="Zp0kgeS-aUyy65UDXgk6uA" name="Drug absorption rate (lumen to mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_DrugAbsorption_para" isDefault="1" displayUnit="µmol/min">
-                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
-              </Parameter>
-              <Parameter id="-gHeJsNbVkyb7R_LlEzYoQ" name="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" isDefault="1" displayUnit="µmol/min">
+              <Parameter id="imTOLvU-vkSttZUQmn3m_g" name="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" isDefault="1" displayUnit="µmol/min">
                 <Info flag="52" seq="1" ref="0" bb="2" group="117" />
               </Parameter>
-              <Parameter id="4CS0VFXFXUyuMk___nSIHw" name="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" isDefault="1" displayUnit="µmol/min">
+              <Parameter id="QzEktTOVMUmLhVDFnzBiZQ" name="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" isDefault="1" displayUnit="µmol/min">
                 <Info flag="52" seq="1" ref="0" bb="2" group="117" />
               </Parameter>
             </Children>
           </Container>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="KK40WSlih0ehm8uQK_7UIg" name="Duodenum_pls_PortalVein_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="OKXf1Dl7Jk-2HzmG8_06yw" secondNeighbor="5TpyW0Sd9USQGXc2frzUgA">
+      <NeighborhoodBuilder id="EEbTn9yUnkiVM4B7i8b4xA" name="Caecum_pls_PortalVein_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="6rbF-W8rIUq5hZ8odtvzrQ" secondNeighbor="d626iVqs-ESin5Db2bAqWg">
         <Tags>
           <Tag value="Neighborhood: Plasma / Plasma" />
         </Tags>
         <Children>
-          <Container id="kCd3P4q0Mki49SzwS7PKqA" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="XI4HAoeMuU6dc3LLHA7E9A" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="BNdHRBef3UKXm-e_8lYmBg" name="Mass transfer rate (mucosa to portal vein plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_forTwoPores.PARAM_MassTransferMucosaToPvePlasma" isDefault="1" displayUnit="µmol/min">
+              <Parameter id="9UXnU0ylQ0Gsju751clXfA" name="Mass transfer rate (mucosa to portal vein plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_forTwoPores.PARAM_MassTransferMucosaToPvePlasma" isDefault="1" displayUnit="µmol/min">
                 <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                 <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
               </Parameter>
@@ -22210,14 +22348,14 @@
           </Container>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="MmQyyiw660uwtD9rmf2wWg" name="ColonDescendens_bc_PortalVein_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="dwf9qubqqEi4D7C9ydVugg" secondNeighbor="oz2_zRPfzk-ZhQqUyIQ6kg">
+      <NeighborhoodBuilder id="pA8bL7Yqx0mUvvH_aJytYw" name="Caecum_bc_PortalVein_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="a9ee82hQMEOJZglG6y718g" secondNeighbor="J7qhrNHWA0i3ePh_JHm2LQ">
         <Tags>
           <Tag value="Neighborhood: BloodCells / BloodCells" />
         </Tags>
         <Children>
-          <Container id="31QkhmWpg0OpyEV2j9pohQ" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="d-vmMiRXrUCMJaSTQBJoAQ" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="VjSXeOpnBUynTaoEVyyG1Q" name="Mass transfer rate (mucosa to portal vein blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_forTwoPores.PARAM_MassTransferMucosaToPveBloodCells" isDefault="1" displayUnit="µmol/min">
+              <Parameter id="zEqOyMrv_EWanVFnm6wnWg" name="Mass transfer rate (mucosa to portal vein blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_forTwoPores.PARAM_MassTransferMucosaToPveBloodCells" isDefault="1" displayUnit="µmol/min">
                 <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                 <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
               </Parameter>
@@ -22225,147 +22363,147 @@
           </Container>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="xLdm_7tc_0iu6CiaseRgpQ" name="ColonDescendens_pls_PortalVein_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="vL02efQGCU-ZjeiGD2sJSg" secondNeighbor="5TpyW0Sd9USQGXc2frzUgA">
+      <NeighborhoodBuilder id="Hl9hZdeH80-xsAmPnz2ZBA" name="Lumen_colasc_ColonAscendens_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="IIG08bkIP0mqw9u39eWCjA" secondNeighbor="NXXWdgTHKkOgaKy-_Ihsfg">
         <Tags>
-          <Tag value="Neighborhood: Plasma / Plasma" />
+          <Tag value="Neighborhood: ColonAscendens / Plasma" />
         </Tags>
         <Children>
-          <Container id="q3Fy98FWL0qqH4NXdKczAw" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="Dvyem1lgXUmMx1tbHE7bXQ" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="IIrUDgF2DEOHlIORPAaXyg" name="Mass transfer rate (mucosa to portal vein plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_forTwoPores.PARAM_MassTransferMucosaToPvePlasma" isDefault="1" displayUnit="µmol/min">
-                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+              <Parameter id="CsyUkmPWLEynl-rTtsW-9Q" name="Drug absorption rate (lumen to mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_DrugAbsorption_para" isDefault="1" displayUnit="µmol/min">
                 <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
               </Parameter>
+              <Parameter id="1YvJF4v2JUGdArejJpcJdg" name="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" isDefault="1" displayUnit="µmol/min">
+                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
+              <Parameter id="-ZWRiQPOREOdiiiAJSUX4w" name="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" isDefault="1" displayUnit="µmol/min">
+                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
             </Children>
           </Container>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="xH06iEVcekaFh7yYgYDyeg" name="Lumen_coldesc_ColonDescendens_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="YZUlLOUbckymPftQV_qzhg" secondNeighbor="mKycGZxaxU-wbBAV1rukfw">
+      <NeighborhoodBuilder id="JJ0dlHfR40umMO-hQopvhw" name="Lumen_colasc_ColonAscendens_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="IIG08bkIP0mqw9u39eWCjA" secondNeighbor="S-Rw4kxIuk2Mzq3AJUGeAg">
         <Tags>
-          <Tag value="Neighborhood: ColonDescendens / Intracellular" />
+          <Tag value="Neighborhood: ColonAscendens / Intracellular" />
         </Tags>
         <Children>
-          <Container id="5I3C1IiwA0mDj9j7YgCf3g" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="QK4J7MMTLkGFUvtSMgUvJA" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="_igkAa54ek6hPqDQGHsKlg" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K3" isDefault="1">
-                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              <Parameter id="AmI-8RGePkWYpUlO8I2aFA" name="Drug absorption rate (lumen to mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_DrugAbsorption_trans" isDefault="1" displayUnit="µmol/min">
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
               </Parameter>
-              <Parameter id="s0_FAbbc6EKxTOxDvi2iYQ" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K4" isDefault="1">
+              <Parameter id="C9K-FLk4-Uye1vgTya1Z4A" name="P_int_trans_cell_lum_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_cell_lum_factor" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="ekJCsijVkEOt7zCcKqXk4w" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K5" isDefault="1">
+              <Parameter id="p5_xcGUkKUavpV63NeMZvA" name="P_int_trans_lum_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_lum_cell_factor" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="O7EFhC2aGEeGh7lUfhVydg" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K6" isDefault="1">
-                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              <Parameter id="VsYrOX6UqkiP-y8ftI-u2g" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_K_cell_pls_ColonAscendens" isDefault="1">
+                <Info min="0" flag="36" seq="1" ref="0" bb="2" group="67" />
               </Parameter>
-              <Parameter id="O8t8Hl7HXEKv35-jkKLWCg" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K7" isDefault="1">
-                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              <Parameter id="V8e_eI-0NkuDixaaGFn7tA" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_ColonAscendens" isDefault="1">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
               </Parameter>
-              <Parameter id="wE509qecTkGX4abmDWia5g" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K8" isDefault="1">
+              <Parameter id="QyNSQqU4XUOmKTFB2wHp7w" name="pKa_pH_WS_cell_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F1" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="zgdFgQFYJ0ac8zghGYfvYA" name="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" isDefault="1" displayUnit="µmol/min">
-                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
-              </Parameter>
-              <Parameter id="RbyGJzV3LE6iJ6A3EF7ASQ" name="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" isDefault="1" displayUnit="µmol/min">
-                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
-              </Parameter>
-              <Parameter id="ByR1bVs4PkCxdPoQp4uNxQ" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F3" isDefault="1">
+              <Parameter id="uFeUsVIF6E-j2PmcdKWhHA" name="pKa_pH_WS_cell_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F2" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="t3uHoAgNU0WWbl1HiNFWGQ" name="pKa_pH_WS_cell_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F3" isDefault="1">
+              <Parameter id="mk8uCG5NX0CzGa6kE1AEPA" name="pKa_pH_WS_cell_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F3" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="sxAqY-AA4Ue9FNiYtoCjHA" name="Drug absorption rate (lumen to mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_DrugAbsorption_trans" isDefault="1" displayUnit="µmol/min">
-                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+              <Parameter id="vYABE3KeY0WK_oEnrvmb2A" name="pKa_pH_WS_cell_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K1" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="VXMSOoLiz02UwJhiM0z1xw" name="P_int_trans_cell_lum_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_cell_lum_factor" isDefault="1">
+              <Parameter id="xfO0luAMCkqtBa3Nv_n4mQ" name="pKa_pH_WS_cell_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K2" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="QMGr5bAgrUyYAV7pnSYsYg" name="P_int_trans_lum_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_lum_cell_factor" isDefault="1">
+              <Parameter id="XxaXCov_Bk6SOXIUZcP8kA" name="pKa_pH_WS_cell_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K3" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="6xe8HT9NOEGbAlqeWMavvw" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_K_cell_pls_ColonDescendens" isDefault="1">
-                <Info min="0" flag="36" seq="1" ref="0" bb="2" group="67" />
+              <Parameter id="VaWuw-GfAE2qyGT9wonRjg" name="pKa_pH_WS_cell_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K4" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="nYRnFP0HLUmql1zLokd-Vw" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_ColonDescendens" isDefault="1">
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+              <Parameter id="Nnmx1soW1kGxLWhBGwsfIw" name="pKa_pH_WS_cell_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K5" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="IHIP_D0oWE64VPTn3kvSsg" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K2" isDefault="1">
+              <Parameter id="wsH1MEqKG0aGMWqC0v5meA" name="pKa_pH_WS_cell_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K6" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="V7jdwFrl8UGTTnsv5Hq0zg" name="pKa_pH_WS_cell_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F2" isDefault="1">
+              <Parameter id="kN4sdfjHUUmfnkYVXbHMtw" name="pKa_pH_WS_cell_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K7" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="CAobaVajwEyEsbUp7RH8xQ" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K1" isDefault="1">
+              <Parameter id="diji6zW0ukCRJspdSpYwnA" name="pKa_pH_WS_cell_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K8" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
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+              <Parameter id="xpVYJmOvPkqtfo6tXegFhQ" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F1" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
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+              <Parameter id="q2A30TbaZ0WeQsdfRCg7nA" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F2" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
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+              <Parameter id="5-Un6-hLpEiMQuzN82ciFw" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F3" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="8B7jhhE4kEm0E90IXW1Azg" name="pKa_pH_WS_cell_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K4" isDefault="1">
+              <Parameter id="5h1FmW1F1Uadw91X8CIK3w" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K1" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
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+              <Parameter id="CASAobWspEy5GW7TUaEwUw" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K2" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="zNIjJOlAOUeBF6O9281xZA" name="pKa_pH_WS_cell_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K6" isDefault="1">
+              <Parameter id="v8oVmAxT00uCEkaCXBJgeA" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K3" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
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+              <Parameter id="SwNiQYH_rkubaqOMC7R84g" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K4" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="8NOf0ogj30yY3vmWXroZqg" name="pKa_pH_WS_cell_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K8" isDefault="1">
+              <Parameter id="fXSnGQgtqE2yPDBhuZbJrQ" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K5" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="ibA1jESM1EuUM8bLO3fPCQ" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F1" isDefault="1">
+              <Parameter id="re-IZY4QekO8SuE72NlhYA" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K6" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="eDy2NsGL206p8-18YY_-Kg" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F2" isDefault="1">
+              <Parameter id="MWByhnSQh0WTeeASkeGHbQ" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K7" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="jq7m1lq3G0qEd4YtjV6qlg" name="pKa_pH_WS_cell_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F1" isDefault="1">
+              <Parameter id="MReiQ0pDRkeKboIPJa9wFw" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K8" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
+              <Parameter id="V0gvq6zKgkKy66VFncnz2A" name="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" isDefault="1" displayUnit="µmol/min">
+                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
+              <Parameter id="N-dcNdvilEirghnQo7EsVA" name="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" isDefault="1" displayUnit="µmol/min">
+                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
             </Children>
           </Container>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="4cmHMtCPTUmrK4EgmJmzPw" name="Lumen_coldesc_ColonDescendens_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="YZUlLOUbckymPftQV_qzhg" secondNeighbor="vL02efQGCU-ZjeiGD2sJSg">
+      <NeighborhoodBuilder id="ILJBW2FVGk6VzOoLEzDGzA" name="ColonAscendens_pls_PortalVein_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="NXXWdgTHKkOgaKy-_Ihsfg" secondNeighbor="d626iVqs-ESin5Db2bAqWg">
         <Tags>
-          <Tag value="Neighborhood: ColonDescendens / Plasma" />
+          <Tag value="Neighborhood: Plasma / Plasma" />
         </Tags>
         <Children>
-          <Container id="MAbBMsjDPkuRDp73y5_pFQ" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="fc-nHbVyuUWH5FA23rOHcg" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="l2y8yeRrQkWjwx-9Bbi9Sw" name="Drug absorption rate (lumen to mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_DrugAbsorption_para" isDefault="1" displayUnit="µmol/min">
+              <Parameter id="pieC3g8tHE6XtnLLXa8YFA" name="Mass transfer rate (mucosa to portal vein plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_forTwoPores.PARAM_MassTransferMucosaToPvePlasma" isDefault="1" displayUnit="µmol/min">
+                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                 <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
               </Parameter>
-              <Parameter id="Gc8qinSXb0GIzRWW0Nxplg" name="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" isDefault="1" displayUnit="µmol/min">
-                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
-              </Parameter>
-              <Parameter id="EW6h2nTcEUKlMIiYXQjsCQ" name="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" isDefault="1" displayUnit="µmol/min">
-                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
-              </Parameter>
             </Children>
           </Container>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="_QE7kRWbnUeXFfLE1NJCBA" name="ColonTransversum_bc_PortalVein_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="4px34OREBESTH634hwSRsQ" secondNeighbor="oz2_zRPfzk-ZhQqUyIQ6kg">
+      <NeighborhoodBuilder id="1f0B_HOBrkiUrNdl_2rgIQ" name="ColonAscendens_bc_PortalVein_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="Zh1OO87Y9kW0nA9-toCWqg" secondNeighbor="J7qhrNHWA0i3ePh_JHm2LQ">
         <Tags>
           <Tag value="Neighborhood: BloodCells / BloodCells" />
         </Tags>
         <Children>
-          <Container id="ZLOv4xN7KUyVsy1_Sukdrg" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="ldqTplZgSU6SnXinS9X-OA" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="KCm8HAO7NU2AelcPeLjzeA" name="Mass transfer rate (mucosa to portal vein blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_forTwoPores.PARAM_MassTransferMucosaToPveBloodCells" isDefault="1" displayUnit="µmol/min">
+              <Parameter id="kAwW8uVEnUOJ9S8nRng0pQ" name="Mass transfer rate (mucosa to portal vein blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_forTwoPores.PARAM_MassTransferMucosaToPveBloodCells" isDefault="1" displayUnit="µmol/min">
                 <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                 <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
               </Parameter>
@@ -22373,210 +22511,295 @@
           </Container>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="-JGWomg1KUe5EiN-OzaQJw" name="Lumen_coltrans_ColonTransversum_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="ie3h9CgxCU284p0wLjL9fw" secondNeighbor="_8WPOqeesEqTiq7LFrBEqQ">
+      <NeighborhoodBuilder id="ltexfZKGLkSjLD03Go9ccg" name="Lumen_coltrans_ColonTransversum_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="gOwWT2AqWk2pbTe4eeu9iw" secondNeighbor="dKKkV4FxmUC1PUPd2DghIQ">
+        <Tags>
+          <Tag value="Neighborhood: ColonTransversum / Plasma" />
+        </Tags>
+        <Children>
+          <Container id="emH-k63yJkqVaWMAB3xO4g" name="MoleculeProperties" mode="Logical" containerType="Other">
+            <Children>
+              <Parameter id="T6qAZ3Azs06o9tXSEHp_8Q" name="Drug absorption rate (lumen to mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_DrugAbsorption_para" isDefault="1" displayUnit="µmol/min">
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+              </Parameter>
+              <Parameter id="uJLuFous_E-DlP3jlj20XA" name="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" isDefault="1" displayUnit="µmol/min">
+                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
+              <Parameter id="6zlEInLYtU-b17lGdQ-uDA" name="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" isDefault="1" displayUnit="µmol/min">
+                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
+            </Children>
+          </Container>
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="fbjFdFkp6ki_-kEZyp5D9Q" name="Lumen_coltrans_ColonTransversum_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="gOwWT2AqWk2pbTe4eeu9iw" secondNeighbor="9Lccn4BuWUWFz52tXH9heA">
         <Tags>
           <Tag value="Neighborhood: ColonTransversum / Intracellular" />
         </Tags>
         <Children>
-          <Container id="GbRC7rr6nkKM7LioIjCxwA" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="r6aoyK91BEaFQoBDg5y1tQ" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="bl9RDwL-ZkSXfjVKQV6Hzw" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K2" isDefault="1">
+              <Parameter id="J4IYww6L9kWhcv4ENRvvfQ" name="Drug absorption rate (lumen to mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_DrugAbsorption_trans" isDefault="1" displayUnit="µmol/min">
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+              </Parameter>
+              <Parameter id="5Gwpuatb8EG72jp_DLFUUw" name="P_int_trans_cell_lum_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_cell_lum_factor" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="jdWNVehWf0CuqETl_BsqdA" name="pKa_pH_WS_cell_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K1" isDefault="1">
+              <Parameter id="Gbown1th4EC47tBAfvWpxw" name="P_int_trans_lum_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_lum_cell_factor" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="uJ6442fmoEGfpHneasvXlg" name="pKa_pH_WS_cell_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K2" isDefault="1">
+              <Parameter id="rMW2-1Q0r0iVBq8zJCFiaQ" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_K_cell_pls_ColonTransversum" isDefault="1">
+                <Info min="0" flag="36" seq="1" ref="0" bb="2" group="67" />
+              </Parameter>
+              <Parameter id="sd-dxPBGo0yhZWQSblQcPA" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_ColonTransversum" isDefault="1">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+              </Parameter>
+              <Parameter id="uASa1rwN_UOQdGuiASJ_Wg" name="pKa_pH_WS_cell_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F1" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="HOar4lVo6k-BJ98HewAwoQ" name="pKa_pH_WS_cell_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K3" isDefault="1">
+              <Parameter id="ex-Z1VjZ1EeLMLPouqbmOw" name="pKa_pH_WS_cell_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F2" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="r05xMB7JcEGUzAUf7YpsWQ" name="pKa_pH_WS_cell_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K4" isDefault="1">
+              <Parameter id="YBIi5OMXG0iXrn7MeLCd8w" name="pKa_pH_WS_cell_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F3" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="0W8V2RPcpU-2LUqazso3lQ" name="pKa_pH_WS_cell_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K5" isDefault="1">
+              <Parameter id="JZNozv0dR02RTIeCzcYavg" name="pKa_pH_WS_cell_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K1" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="6WbkuRZ6aUe5iqxu8gOr7w" name="pKa_pH_WS_cell_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K6" isDefault="1">
+              <Parameter id="4giV9yTAe0Obn5bIuz8CEw" name="pKa_pH_WS_cell_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K2" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="J-bHhCGaB0KeLjWkPRbC-w" name="pKa_pH_WS_cell_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K7" isDefault="1">
+              <Parameter id="hpGQ-jormE2H1Rk8FP4zsw" name="pKa_pH_WS_cell_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K3" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="aIUUgA9wKUyWAhUMpF7ULw" name="pKa_pH_WS_cell_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K8" isDefault="1">
+              <Parameter id="Dcz2B-3VJ0S7i7w03yUa4Q" name="pKa_pH_WS_cell_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K4" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="wZHByJIa8kikYub5j2-VwQ" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F1" isDefault="1">
+              <Parameter id="FSXVbqoquUyGoy92xzYLzQ" name="pKa_pH_WS_cell_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K5" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="wO60jOHPQUmr7E9extJ7ug" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F2" isDefault="1">
+              <Parameter id="VwVzE6ff_EOcVmvvyS6aZg" name="pKa_pH_WS_cell_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K6" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="tL9jogh5OkKDBB1Nj2l5OQ" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K1" isDefault="1">
+              <Parameter id="AOc5e__qFUGxlP1Ph21Bkw" name="pKa_pH_WS_cell_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K7" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="fm5-b04IS062RmqfkxvR6w" name="pKa_pH_WS_cell_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F1" isDefault="1">
+              <Parameter id="tzJOG-dSIk2OHfYPiwQ-WA" name="pKa_pH_WS_cell_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K8" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="uPbp6FqKrEqMWktydpDwYA" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K3" isDefault="1">
+              <Parameter id="rjsIN1OPxEm1y1aEaJo-bA" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F1" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="ldFVOpZ-wUWPN-V8-7Spqg" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K4" isDefault="1">
+              <Parameter id="f5MrzZbXW0e0QuquObiwCg" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F2" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="xS3U5reroU6F8gr4utoNFw" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K5" isDefault="1">
+              <Parameter id="Uy-kymnsVEicOKfzUZkouQ" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F3" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="bOFAx5srBU-YR9V9C6jI4w" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K6" isDefault="1">
+              <Parameter id="iYZdlpoMokesES8CXFlrOQ" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K1" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="U-qiWRvz7EmIpjFoMYUHOQ" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K7" isDefault="1">
+              <Parameter id="ncEK-hb_6Eef0NDh0QzoLg" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K2" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="3RsJddpsdkWA8SxMsARmzA" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K8" isDefault="1">
+              <Parameter id="EYTuL_3t8UOF3ChW05b6KQ" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K3" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="uxLHM0j2vUS6_d0f4T1NNA" name="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" isDefault="1" displayUnit="µmol/min">
-                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+              <Parameter id="n-wSeGLZdka85LfEk1rpUg" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K4" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="Rvbv5w_WxEi6ty8rx7o_wg" name="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" isDefault="1" displayUnit="µmol/min">
-                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+              <Parameter id="qPDCpVW_bUCy3jfFP2U3aw" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K5" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="GVlMPAuMtkOKbnzr33-ymA" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F3" isDefault="1">
+              <Parameter id="1VYERNEfNUac0hfzpLfQTg" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K6" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="QmvWWt6_5k-2h6h6ufcU5w" name="pKa_pH_WS_cell_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F3" isDefault="1">
+              <Parameter id="X_ZBTaZVu0yro1iBFr-cJw" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K7" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="Dqxql2OulEiGZ8YutFtLLQ" name="pKa_pH_WS_cell_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F2" isDefault="1">
+              <Parameter id="eMkC5fLr3EOHTreaSoa8RQ" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K8" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="bWhV5EPWQkKO8mdSpvRTdA" name="Drug absorption rate (lumen to mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_DrugAbsorption_trans" isDefault="1" displayUnit="µmol/min">
+              <Parameter id="FOk1tJCX6UyKhANLs3kZ5g" name="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" isDefault="1" displayUnit="µmol/min">
+                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
+              <Parameter id="UUrkfwhMRkuNBtpsk7FAlg" name="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" isDefault="1" displayUnit="µmol/min">
+                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
+            </Children>
+          </Container>
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="uSKUj6Rrskiv2oXgE4NAGQ" name="ColonTransversum_pls_PortalVein_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="dKKkV4FxmUC1PUPd2DghIQ" secondNeighbor="d626iVqs-ESin5Db2bAqWg">
+        <Tags>
+          <Tag value="Neighborhood: Plasma / Plasma" />
+        </Tags>
+        <Children>
+          <Container id="J9EDTtRIzEWnpHxJREL4CQ" name="MoleculeProperties" mode="Logical" containerType="Other">
+            <Children>
+              <Parameter id="lS4jdnzVcEW0PzvYaxLWQA" name="Mass transfer rate (mucosa to portal vein plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_forTwoPores.PARAM_MassTransferMucosaToPvePlasma" isDefault="1" displayUnit="µmol/min">
+                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                 <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
               </Parameter>
-              <Parameter id="8grA4v0_n0KTtkngpD_gvA" name="P_int_trans_cell_lum_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_cell_lum_factor" isDefault="1">
-                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+            </Children>
+          </Container>
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="u1Sy6TSvRUKTKpPTksWFEA" name="ColonTransversum_bc_PortalVein_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="k7RtszIIWEWmNkArkmiZyw" secondNeighbor="J7qhrNHWA0i3ePh_JHm2LQ">
+        <Tags>
+          <Tag value="Neighborhood: BloodCells / BloodCells" />
+        </Tags>
+        <Children>
+          <Container id="s3qa_UJUakSLXP84RX0yoA" name="MoleculeProperties" mode="Logical" containerType="Other">
+            <Children>
+              <Parameter id="-bAKnSWppk-co9mu-dnF9A" name="Mass transfer rate (mucosa to portal vein blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_forTwoPores.PARAM_MassTransferMucosaToPveBloodCells" isDefault="1" displayUnit="µmol/min">
+                <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
               </Parameter>
-              <Parameter id="_nFmK74PxE-igu4-9gFatA" name="P_int_trans_lum_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_lum_cell_factor" isDefault="1">
-                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+            </Children>
+          </Container>
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="GaE-KoOsdkaNYi-rP4cmoQ" name="Lumen_coldesc_ColonDescendens_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="swnURfirP0a_IppunMKLQA" secondNeighbor="jZAZ-gTMf0KikSh_Nm6c8Q">
+        <Tags>
+          <Tag value="Neighborhood: ColonDescendens / Plasma" />
+        </Tags>
+        <Children>
+          <Container id="URzHdpICHkWEMVmvwRPkUg" name="MoleculeProperties" mode="Logical" containerType="Other">
+            <Children>
+              <Parameter id="lKzYlQrtfkKGbMzOJZ409g" name="Drug absorption rate (lumen to mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_DrugAbsorption_para" isDefault="1" displayUnit="µmol/min">
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
               </Parameter>
-              <Parameter id="1b0n6jiIL0yn7S3QqCEv9Q" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_K_cell_pls_ColonTransversum" isDefault="1">
-                <Info min="0" flag="36" seq="1" ref="0" bb="2" group="67" />
+              <Parameter id="__W0Chdpp02xnLcCxF7dLQ" name="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" isDefault="1" displayUnit="µmol/min">
+                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
               </Parameter>
-              <Parameter id="eSvkME6ui0OK0YjoqxWFcw" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_ColonTransversum" isDefault="1">
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+              <Parameter id="Ko8lRIHdIEGosAEGcUu7LQ" name="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" isDefault="1" displayUnit="µmol/min">
+                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
               </Parameter>
             </Children>
           </Container>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="G8buBMd84Ue2Fb3OywlSNQ" name="Lumen_colsigm_ColonSigmoid_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="B12kRDWtqUGL5miHA0Saxg" secondNeighbor="ECAR3iZfl0CtlZHp7S_zaQ">
+      <NeighborhoodBuilder id="etOPz7AoAUSWOgf-9JlSZA" name="Lumen_coldesc_ColonDescendens_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="swnURfirP0a_IppunMKLQA" secondNeighbor="WRzvpRIMeE6obqJjnbY-sQ">
         <Tags>
-          <Tag value="Neighborhood: ColonSigmoid / Intracellular" />
+          <Tag value="Neighborhood: ColonDescendens / Intracellular" />
         </Tags>
         <Children>
-          <Container id="JbVc2iS-iUGQU5e3kiG5IA" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="BQWMd4atH0yLyi31R9WfZg" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="kjEnn1BCH0m93z_9FRDx-w" name="Drug absorption rate (lumen to mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_DrugAbsorption_trans" isDefault="1" displayUnit="µmol/min">
+              <Parameter id="wnIQOBF0vUqH7LS5pdbeOw" name="Drug absorption rate (lumen to mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_DrugAbsorption_trans" isDefault="1" displayUnit="µmol/min">
                 <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
               </Parameter>
-              <Parameter id="wpa5HrqhYUyTirvlGq9-lQ" name="P_int_trans_cell_lum_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_cell_lum_factor" isDefault="1">
+              <Parameter id="FD81-gGqjEO-C0RsgxKE8w" name="P_int_trans_cell_lum_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_cell_lum_factor" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="leFJ98joG0qUSSZPr_WGeA" name="P_int_trans_lum_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_lum_cell_factor" isDefault="1">
+              <Parameter id="v9zQi8ddmkG-MiSBdQmdKw" name="P_int_trans_lum_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_lum_cell_factor" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="WkN2rCwNbE6dbZhEnsW8yw" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_K_cell_pls_ColonSigmoid" isDefault="1">
+              <Parameter id="uZ2NSbq76UiPv5JXViG1mQ" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_K_cell_pls_ColonDescendens" isDefault="1">
                 <Info min="0" flag="36" seq="1" ref="0" bb="2" group="67" />
               </Parameter>
-              <Parameter id="Sj3-ZeQgPEyliaFty9hYNA" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_ColonSigmoid" isDefault="1">
+              <Parameter id="clejQNEAwUCN_nCy3Nb5dA" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_ColonDescendens" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
               </Parameter>
-              <Parameter id="5B5U1Dhiy0-I0N7Utt2zIg" name="pKa_pH_WS_cell_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F3" isDefault="1">
+              <Parameter id="y6slLu_WMk-mT1EKwijFNw" name="pKa_pH_WS_cell_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F1" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="AYcXpDvd9U2HED2WfRT_Lw" name="pKa_pH_WS_cell_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F1" isDefault="1">
+              <Parameter id="n0_6pOlvtEm7rkGnEI_3lQ" name="pKa_pH_WS_cell_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F2" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="gfk0cllICEaEp5ObK_qKVA" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K2" isDefault="1">
+              <Parameter id="NlINHAWVmUyHSy7NodyOOQ" name="pKa_pH_WS_cell_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F3" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="kAe3A66ugU2Q5Dg3qoX5-Q" name="pKa_pH_WS_cell_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K1" isDefault="1">
+              <Parameter id="xcp1U1LRwUqDLt_Kf8F3XQ" name="pKa_pH_WS_cell_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K1" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="RTTWQlh0oUqDRzlYqdKC5w" name="pKa_pH_WS_cell_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K2" isDefault="1">
+              <Parameter id="2Z4_8XRxxkK5nVB0s_rqcw" name="pKa_pH_WS_cell_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K2" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="eVMLNbRwFUmuKO3958OWnQ" name="pKa_pH_WS_cell_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K3" isDefault="1">
+              <Parameter id="L-XwhOl0A0WUm2bmGcoeUw" name="pKa_pH_WS_cell_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K3" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="bcX5_dwk8k6VaO91Uf7QdQ" name="pKa_pH_WS_cell_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K4" isDefault="1">
+              <Parameter id="ilCo6oYAy0mnnbsfi6fCYw" name="pKa_pH_WS_cell_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K4" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="yPMM6WwnP0mKQstJszgyEg" name="pKa_pH_WS_cell_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K5" isDefault="1">
+              <Parameter id="OvePULYYO0imwssV37SP-Q" name="pKa_pH_WS_cell_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K5" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="2iAZ-NU4B0CGjxgtmfKJlQ" name="pKa_pH_WS_cell_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K6" isDefault="1">
+              <Parameter id="sjK4ueDvdUKKq9dOswWxNw" name="pKa_pH_WS_cell_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K6" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="Jc5_Ho5L8USCRkScxBLnxA" name="pKa_pH_WS_cell_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K7" isDefault="1">
+              <Parameter id="Cpf76v7cNkeCGbx5txJKNQ" name="pKa_pH_WS_cell_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K7" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="84bJozxwgkaGXL1d84FjbA" name="pKa_pH_WS_cell_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K8" isDefault="1">
+              <Parameter id="9vZkjltz1kuOEaQE4ujH1w" name="pKa_pH_WS_cell_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K8" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="gPb8_Ksutki2nEpPMFoTag" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F1" isDefault="1">
+              <Parameter id="iY71d1rvC0K0spOMvHIXLw" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F1" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="tBpIJlVdpk2aogr4g1iimg" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F2" isDefault="1">
+              <Parameter id="rlsOblv7VkGQRGDqJgH1OA" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F2" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="2do2_muBWkeEpJBb3kSBSw" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K1" isDefault="1">
+              <Parameter id="UImVm0Ot_keUtSaTux3LVw" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F3" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="vgx3JCq60U6D5PnRP2oZeQ" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K3" isDefault="1">
+              <Parameter id="x-XZqR9rw0OptFgMN9KbAw" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K1" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="yF8HfwxzRkqa499etO5-gg" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K4" isDefault="1">
+              <Parameter id="_IRFeIBz9kmutD94DGj1Bg" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K2" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="K7zIbwzjqUmqZdhxDongZg" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K5" isDefault="1">
+              <Parameter id="a_oNH5uHV0i1ueZzqJ7oUg" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K3" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="wa8_Arxci0a3Govtrw1ZsA" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K6" isDefault="1">
+              <Parameter id="S3ksVdfLIkKdO_Q4YGmTEA" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K4" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="-hkR7GuFzkuVb1nAQHJY1A" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K7" isDefault="1">
+              <Parameter id="QYk59YRg-0uCabS3iIgA0g" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K5" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="F4yRjET36kiSWk5AG8DEyA" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K8" isDefault="1">
+              <Parameter id="HXohWoek_kq3r6wB67Y5ew" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K6" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="6sIK_42ER02js56XzDHLEA" name="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" isDefault="1" displayUnit="µmol/min">
-                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+              <Parameter id="CjJQ8gH0EEOETAikH89eyA" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K7" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="eaA1zvC6r065mJnxT1dj7g" name="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" isDefault="1" displayUnit="µmol/min">
+              <Parameter id="aV613RU0SEunit2v9rEqVQ" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K8" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="nRnryJ4Ii0SWo1e-EF7AJw" name="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" isDefault="1" displayUnit="µmol/min">
                 <Info flag="52" seq="1" ref="0" bb="2" group="117" />
               </Parameter>
-              <Parameter id="l_DZxYBhRUS4MH11g-mP_g" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F3" isDefault="1">
-                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              <Parameter id="r-G44kCzH0uVZ47N2bdTNQ" name="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" isDefault="1" displayUnit="µmol/min">
+                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
               </Parameter>
-              <Parameter id="d1me7Wif2E6DL1gvaEpjPg" name="pKa_pH_WS_cell_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F2" isDefault="1">
-                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+            </Children>
+          </Container>
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="e1Rhof5eHEupnMRx98uwOw" name="ColonDescendens_pls_PortalVein_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="jZAZ-gTMf0KikSh_Nm6c8Q" secondNeighbor="d626iVqs-ESin5Db2bAqWg">
+        <Tags>
+          <Tag value="Neighborhood: Plasma / Plasma" />
+        </Tags>
+        <Children>
+          <Container id="ivPzuTDJ50eOyTI11xRqxw" name="MoleculeProperties" mode="Logical" containerType="Other">
+            <Children>
+              <Parameter id="6wnb1vzmLEy5hUem_GXypA" name="Mass transfer rate (mucosa to portal vein plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_forTwoPores.PARAM_MassTransferMucosaToPvePlasma" isDefault="1" displayUnit="µmol/min">
+                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
               </Parameter>
             </Children>
           </Container>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="cidaG24kXEmEOtXok3jlyA" name="ColonAscendens_bc_PortalVein_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="qmb47oXwu06rIgurXdkdAg" secondNeighbor="oz2_zRPfzk-ZhQqUyIQ6kg">
+      <NeighborhoodBuilder id="JNhbM86XiEeyeXlf6OCZ5g" name="ColonDescendens_bc_PortalVein_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="-WuEPhTZIUycjwSP04xTJw" secondNeighbor="J7qhrNHWA0i3ePh_JHm2LQ">
         <Tags>
           <Tag value="Neighborhood: BloodCells / BloodCells" />
         </Tags>
         <Children>
-          <Container id="CT9Ozov9vkSIr49VEYtl2Q" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="g2P4_JDOTUqR28cYHVEyXg" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="gN-7Pxz17US47Ol3Cvd3Rg" name="Mass transfer rate (mucosa to portal vein blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_forTwoPores.PARAM_MassTransferMucosaToPveBloodCells" isDefault="1" displayUnit="µmol/min">
+              <Parameter id="A9n7d_zLUkO_xOqq0vYzyQ" name="Mass transfer rate (mucosa to portal vein blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_forTwoPores.PARAM_MassTransferMucosaToPveBloodCells" isDefault="1" displayUnit="µmol/min">
                 <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                 <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
               </Parameter>
@@ -22584,162 +22807,132 @@
           </Container>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="RZAWJ0GBQ0aE0u4PSooeqg" name="ColonAscendens_pls_PortalVein_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="m5wMdFXfeU2GNaT-cMXNww" secondNeighbor="5TpyW0Sd9USQGXc2frzUgA">
+      <NeighborhoodBuilder id="Dd3W302c3Ei9ozurwYJvTQ" name="Lumen_colsigm_ColonSigmoid_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="8EVK1diXzEKNlC-Y6QOZJg" secondNeighbor="WV8-rtxb-kqkvGTxuUS_Vg">
         <Tags>
-          <Tag value="Neighborhood: Plasma / Plasma" />
+          <Tag value="Neighborhood: ColonSigmoid / Plasma" />
         </Tags>
         <Children>
-          <Container id="v0M2hcukIEeYZqHnfr5n1w" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="JWq1m9ITs0Co2XY7rcTtew" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="SVzgAl_d-0GDdDw4rEpANA" name="Mass transfer rate (mucosa to portal vein plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_forTwoPores.PARAM_MassTransferMucosaToPvePlasma" isDefault="1" displayUnit="µmol/min">
-                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+              <Parameter id="qpCDGAbCgUCmxGmS_pVzhA" name="Drug absorption rate (lumen to mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_DrugAbsorption_para" isDefault="1" displayUnit="µmol/min">
                 <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
               </Parameter>
+              <Parameter id="c-QiXL38GkO8BRl7eTnytA" name="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" isDefault="1" displayUnit="µmol/min">
+                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
+              <Parameter id="SLm7p4RaPUeiE-0dex4weA" name="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" isDefault="1" displayUnit="µmol/min">
+                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
             </Children>
           </Container>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="L3C06Gn3SkWojOomL9crGw" name="Lumen_colasc_ColonAscendens_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="alASnwRuBk-kXDoH0sPohw" secondNeighbor="EQk07EvEgUeogHnziDRsgg">
+      <NeighborhoodBuilder id="SMOb9qmlBEGhjkY2e8OHvw" name="Lumen_colsigm_ColonSigmoid_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="8EVK1diXzEKNlC-Y6QOZJg" secondNeighbor="XqUZ4UhE-EyE99zEOxxkNg">
         <Tags>
-          <Tag value="Neighborhood: ColonAscendens / Intracellular" />
+          <Tag value="Neighborhood: ColonSigmoid / Intracellular" />
         </Tags>
         <Children>
-          <Container id="bSUTq12Ugkig97Oi6EkExQ" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="etiB9vDFjE69fMOkVVN26g" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="rtcKhHsSYkCgCQ12kr80gA" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K3" isDefault="1">
-                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              <Parameter id="BevDSvH-gEuk2Nnrd6PofQ" name="Drug absorption rate (lumen to mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_DrugAbsorption_trans" isDefault="1" displayUnit="µmol/min">
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
               </Parameter>
-              <Parameter id="q1TWVj575EuphOQoHJMrqQ" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K4" isDefault="1">
+              <Parameter id="C-l8gEmteECcImyr4Up1OA" name="P_int_trans_cell_lum_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_cell_lum_factor" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="Yv-bwiCXyU6wp1c7KSjLvw" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K5" isDefault="1">
+              <Parameter id="iQehxHu4n0GIGwlRj-YoVw" name="P_int_trans_lum_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_lum_cell_factor" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="4_cUAhwp_UOKcmHOtG0zuQ" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K6" isDefault="1">
-                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              <Parameter id="257s8TOyY0-c8JEnAopNhw" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_K_cell_pls_ColonSigmoid" isDefault="1">
+                <Info min="0" flag="36" seq="1" ref="0" bb="2" group="67" />
               </Parameter>
-              <Parameter id="cDAq-XYhwEiTDQZlQ6XPbA" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K7" isDefault="1">
-                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              <Parameter id="jX7Mrx0d40Cfy9eMZunyuw" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_ColonSigmoid" isDefault="1">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
               </Parameter>
-              <Parameter id="Mlr0DEoucUq1nrNYvF3LCg" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K8" isDefault="1">
+              <Parameter id="K0lpxBNcIUG5TZ_ZUY0m2A" name="pKa_pH_WS_cell_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F1" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="WfhKlyaj4UCbPWKTOMpBCg" name="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" isDefault="1" displayUnit="µmol/min">
-                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
-              </Parameter>
-              <Parameter id="QbxM86S65U6R0QZCuw1ZWQ" name="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" isDefault="1" displayUnit="µmol/min">
-                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
-              </Parameter>
-              <Parameter id="yuVjMS-7lUeiAjpgswsVdQ" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F3" isDefault="1">
+              <Parameter id="7vN74wpIH06TeAU38B-tiQ" name="pKa_pH_WS_cell_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F2" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="98_w2jLdYk-pFNRsPR_KLg" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K2" isDefault="1">
+              <Parameter id="qyY7Mc7m4UO4IgToZyX0sA" name="pKa_pH_WS_cell_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F3" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="YzpirojlPkSFl3w1H_AnUw" name="pKa_pH_WS_cell_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F3" isDefault="1">
+              <Parameter id="XHJcAl2a_EeOSlt3Xgxbsw" name="pKa_pH_WS_cell_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K1" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="Q95t32UiM0iOSKIFZaAwcw" name="Drug absorption rate (lumen to mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_DrugAbsorption_trans" isDefault="1" displayUnit="µmol/min">
-                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
-              </Parameter>
-              <Parameter id="IwOvil2Rrkqiy2Tjk06ViA" name="P_int_trans_cell_lum_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_cell_lum_factor" isDefault="1">
+              <Parameter id="GhP9PIS9cEGXLBT1_q6HjQ" name="pKa_pH_WS_cell_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K2" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="SCGzByZwRUGyF6yMmntfjg" name="P_int_trans_lum_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_lum_cell_factor" isDefault="1">
+              <Parameter id="lQ1dV1bIRUuHrh_LiAEzYA" name="pKa_pH_WS_cell_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K3" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="FshvQa35_EWQy5-yhF6oFg" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_K_cell_pls_ColonAscendens" isDefault="1">
-                <Info min="0" flag="36" seq="1" ref="0" bb="2" group="67" />
-              </Parameter>
-              <Parameter id="pvumrR_NhE2BzwCyQzMUcQ" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_ColonAscendens" isDefault="1">
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
-              </Parameter>
-              <Parameter id="wJ-xRq5VoEGE23E5Q3H2vw" name="pKa_pH_WS_cell_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F2" isDefault="1">
+              <Parameter id="ty5ahAIFSkeMfonzeP7L9Q" name="pKa_pH_WS_cell_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K4" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="Ap7NBiM8CkS98KelygdWKw" name="pKa_pH_WS_cell_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K1" isDefault="1">
+              <Parameter id="CZsVhNFOhEGa3WhMSkguwQ" name="pKa_pH_WS_cell_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K5" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="JduOBuZyIUGs6Ywcqnt6Kw" name="pKa_pH_WS_cell_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K2" isDefault="1">
+              <Parameter id="WkjJocQsf0eBxqnFxu4mJg" name="pKa_pH_WS_cell_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K6" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="F_By9BLURESKfRzi2uG8JA" name="pKa_pH_WS_cell_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K3" isDefault="1">
+              <Parameter id="VzlWJ3EblE2uLo4ixxhj-w" name="pKa_pH_WS_cell_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K7" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="Jc81qhQTJEWAiSSVQeM2dA" name="pKa_pH_WS_cell_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K4" isDefault="1">
+              <Parameter id="ojFNN_k760mIWweIPBwQOA" name="pKa_pH_WS_cell_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K8" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="H0EfZXUkn0muqb-lTbo50g" name="pKa_pH_WS_cell_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K5" isDefault="1">
+              <Parameter id="3BrUZTRWRUCu1efeD6Jt9g" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F1" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="7J5oY3FZ50Wb3p7CAfzl6Q" name="pKa_pH_WS_cell_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K6" isDefault="1">
+              <Parameter id="JMWSaZj3j0m8N5TATESNqg" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F2" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="kkOulkR140a6_9SLoklW2A" name="pKa_pH_WS_cell_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K7" isDefault="1">
+              <Parameter id="toMv3CZf-EOlGEP-gG8Tgw" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F3" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="phrwTdZ-206ba0GVvpX6SQ" name="pKa_pH_WS_cell_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K8" isDefault="1">
+              <Parameter id="YNiF1qLNGkeESsxERDIexg" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K1" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="3Tez_UyBb02lXsEDjAC9vw" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F1" isDefault="1">
+              <Parameter id="BAh6VMdrOUea-pjNfZe7mA" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K2" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="BKa31OPW40u_8N90Jp-Crg" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F2" isDefault="1">
+              <Parameter id="aQllur6bS0ez4IcpIgKfiw" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K3" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="gAwA97QX0UefnZA4lUe6Pw" name="pKa_pH_WS_cell_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F1" isDefault="1">
+              <Parameter id="Qze0KJkQ2k2MIxK1yIgsAA" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K4" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="MCNLL7rl00q84sKlAG91nw" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K1" isDefault="1">
+              <Parameter id="4kpP29xQhUm2bvj4rERyLg" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K5" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
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-        <Tags>
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-        </Tags>
-        <Children>
-          <Container id="9wqYCpNYQUycHq4DFjLpEQ" name="MoleculeProperties" mode="Logical" containerType="Other">
-            <Children>
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-              </Parameter>
-              <Parameter id="73t99BcqnEK0UaJiJ_VReA" name="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" isDefault="1" displayUnit="µmol/min">
-                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
-              </Parameter>
-              <Parameter id="DTzWUsRhz0aPpPuNX0wFBA" name="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" isDefault="1" displayUnit="µmol/min">
-                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+              <Parameter id="BEBu3pg13EW8m8kdQ6ibrw" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K6" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-            </Children>
-          </Container>
-        </Children>
-      </NeighborhoodBuilder>
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-        <Tags>
-          <Tag value="Neighborhood: BloodCells / BloodCells" />
-        </Tags>
-        <Children>
-          <Container id="FIPL-blZ4UOYCXDxcHqAWQ" name="MoleculeProperties" mode="Logical" containerType="Other">
-            <Children>
-              <Parameter id="nCxG9jdyQUyXQ8C5sMsjHw" name="Mass transfer rate (mucosa to portal vein blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_forTwoPores.PARAM_MassTransferMucosaToPveBloodCells" isDefault="1" displayUnit="µmol/min">
-                <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
-                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+              <Parameter id="RZtlTzbrLUeGudkPJMUQjg" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K7" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="oXCqRA_Hrka8Nb91acNwMw" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K8" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="Ugq7RNiRK0KDtGNyymbF_Q" name="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" isDefault="1" displayUnit="µmol/min">
+                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
+              <Parameter id="MX_ekb-_OkmCEGWsYMIIHQ" name="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" isDefault="1" displayUnit="µmol/min">
+                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
               </Parameter>
             </Children>
           </Container>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="QA-uQ4wJzU2Y6pil3Mv9_Q" name="Caecum_pls_PortalVein_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="PdIK1tifAUOH4joR3xeI0A" secondNeighbor="5TpyW0Sd9USQGXc2frzUgA">
+      <NeighborhoodBuilder id="4JAVD0O4t0O9hgJC5Mft5w" name="ColonSigmoid_pls_PortalVein_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="WV8-rtxb-kqkvGTxuUS_Vg" secondNeighbor="d626iVqs-ESin5Db2bAqWg">
         <Tags>
           <Tag value="Neighborhood: Plasma / Plasma" />
         </Tags>
         <Children>
-          <Container id="nUPkShbxK0abJeUGZR0aYQ" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="0Tp8O7OM3Uuh1U3zOS1ZMA" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="2FpQnFzlzUmZzIKb7CJ_4g" name="Mass transfer rate (mucosa to portal vein plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_forTwoPores.PARAM_MassTransferMucosaToPvePlasma" isDefault="1" displayUnit="µmol/min">
+              <Parameter id="3rlW7waT2kaeJNlIxjGSxg" name="Mass transfer rate (mucosa to portal vein plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_forTwoPores.PARAM_MassTransferMucosaToPvePlasma" isDefault="1" displayUnit="µmol/min">
                 <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                 <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
               </Parameter>
@@ -22747,399 +22940,279 @@
           </Container>
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+      <NeighborhoodBuilder id="VsOCj5FiLkOfCJne9BZ5DQ" name="ColonSigmoid_bc_PortalVein_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="bjnkSvC4UkCPwACz1ooOVQ" secondNeighbor="J7qhrNHWA0i3ePh_JHm2LQ">
         <Tags>
-          <Tag value="Neighborhood: Plasma / Plasma" />
+          <Tag value="Neighborhood: BloodCells / BloodCells" />
         </Tags>
         <Children>
-          <Container id="1P8oBzQtGEqGUsXeHasZtg" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="BFlDgumlsUygotwAyXNYzg" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="-TIFMbpF4Ey5XNJaWajqsA" name="Mass transfer rate (mucosa to portal vein plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_forTwoPores.PARAM_MassTransferMucosaToPvePlasma" isDefault="1" displayUnit="µmol/min">
-                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+              <Parameter id="y-hOpymM6ECOfLuB8uXy4w" name="Mass transfer rate (mucosa to portal vein blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_forTwoPores.PARAM_MassTransferMucosaToPveBloodCells" isDefault="1" displayUnit="µmol/min">
+                <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                 <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
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-      <NeighborhoodBuilder id="ajgx8TiIz0StDaXAt-z97g" name="ArterialBlood_bc_Fat_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="b_JwGFelbkeRco3dQKg62Q" secondNeighbor="pr2NEKX92EmUFNEyQWWy0Q">
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-          <Tag value="Neighborhood: BloodCells / BloodCells" />
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+      <NeighborhoodBuilder id="bnTx8bS7JEyi5zp_P1dNcA" name="Pericentral_int_VenousBlood_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="u1i1IAG6dUqxptmmFsMCpQ" secondNeighbor="JxP9aCWtgUGhXH_R7w1Z2Q">
         <Tags>
           <Tag value="Neighborhood: Interstitial / Plasma" />
         </Tags>
         <Children>
-          <Container id="D4catG57QEuxO-dxu7o7eQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="FuGY5RylokqnVp1e206XuQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="eod_tUmYLEOXe3Lfzst-oQ" name="Pericentral_int_VenousBlood_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="7Ba1a4OrwUGcAPeb1mAAzA" secondNeighbor="lg3JPjAHSUaKoE7vwc_rTw">
+      <NeighborhoodBuilder id="tNppbE_ZM0Csh7kP-ZUavQ" name="Periportal_int_VenousBlood_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="uLSnyQvQF0eSRV_PkQEGNg" secondNeighbor="JxP9aCWtgUGhXH_R7w1Z2Q">
         <Tags>
           <Tag value="Neighborhood: Interstitial / Plasma" />
         </Tags>
         <Children>
-          <Container id="THC9bo87CUClhG70Amq1nQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="cGIsyRz3rUu-PAHEElGvnQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="w7uCT79c_EmcT1T5yBuwdA" name="Periportal_cell_Lumen_duo" mode="Logical" containerType="Neighborhood" firstNeighbor="q9Zn8MoV4k-G3DNkmUKaPw" secondNeighbor="Soy8bWRBA0aKD_xjTO8QdQ">
-        <Tags>
-          <Tag value="Neighborhood: Intracellular / Duodenum" />
-        </Tags>
+      <NeighborhoodBuilder id="X7oyYqifAkqybx2j__2ZKQ" name="Pericentral_cell_Gallbladder" mode="Logical" containerType="Neighborhood" firstNeighbor="ds63kU5tRUKYhDEg557hxw" secondNeighbor="K-j3_tP-00WpCilFci4tTw">
         <Children>
-          <Container id="iYGXt3kbp0S8xzF_AnUHhQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="R_g58AeuI0aAQIxOb7JDzA" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="KdWyTZtpnEC54PQpMPE4dA" name="Periportal_end_Organism_ecl" mode="Logical" containerType="Neighborhood" firstNeighbor="2bh0nZ_Y6UOntag5Sp5jGQ" secondNeighbor="eDJJFajIZ0qqc5SSL9V05w">
-        <Tags>
-          <Tag value="Neighborhood: Endosome / EndosomalClearance" />
-        </Tags>
+      <NeighborhoodBuilder id="vCQPggLtLEqVB8eNarXYdA" name="Periportal_cell_Gallbladder" mode="Logical" containerType="Neighborhood" firstNeighbor="m3iM2eCzCE-IODPwxB9WGQ" secondNeighbor="K-j3_tP-00WpCilFci4tTw">
         <Children>
-          <Container id="uIy1ylH1Hk-QyQZEDiuLXA" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="aDfaANr6fkCzKgdoyNjuTQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="Z5Pp_5kFoU-XxnVB34jHnQ" name="Pericentral_end_Organism_ecl" mode="Logical" containerType="Neighborhood" firstNeighbor="s6gle91W0UCjvKebGt-RWw" secondNeighbor="eDJJFajIZ0qqc5SSL9V05w">
+      <NeighborhoodBuilder id="23Jfi-e630GV5MfjKcAtXg" name="Pericentral_pls_VenousBlood_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="RlOyNe34MUaG9Wu53q6mHg" secondNeighbor="JxP9aCWtgUGhXH_R7w1Z2Q">
         <Tags>
-          <Tag value="Neighborhood: Endosome / EndosomalClearance" />
+          <Tag value="Neighborhood: Plasma / Plasma" />
         </Tags>
         <Children>
-          <Container id="gfqDtuSrUkaQQqwkW7asTw" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="3MgMTVWklkulIxCS0xDuoA" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="W1Jhm-Y27Ey-u7ntPXxg2A" name="PortalVein_bc_Periportal_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="oz2_zRPfzk-ZhQqUyIQ6kg" secondNeighbor="c0pnnkb11EiaOMW4lLDk1A">
+      <NeighborhoodBuilder id="wmJuRoUf00aKfSgeROaJEA" name="Periportal_pls_VenousBlood_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="TOpTLsUGc0ma-rRDNQkZfw" secondNeighbor="JxP9aCWtgUGhXH_R7w1Z2Q">
         <Tags>
-          <Tag value="Neighborhood: BloodCells / BloodCells" />
+          <Tag value="Neighborhood: Plasma / Plasma" />
         </Tags>
         <Children>
-          <Container id="RFXUytJr0kevuObPKkSYJg" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="lZNodpRbmESGWtpPuYvPYA" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="kk2IbpxCD0OmxyjMhBSzRw" name="ArterialBlood_pls_Periportal_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="4825D6NCvEaDod9eLrQ1OQ" secondNeighbor="8DZXItaWrkqNKYuUKQ9tjQ">
+      <NeighborhoodBuilder id="Gn53UIXJL0uVNk5BNyTWqA" name="Pericentral_cell_Lumen_duo" mode="Logical" containerType="Neighborhood" firstNeighbor="ds63kU5tRUKYhDEg557hxw" secondNeighbor="Q2OaqR8Xk0-oRedeXkkAcA">
         <Tags>
-          <Tag value="Neighborhood: Plasma / Plasma" />
+          <Tag value="Neighborhood: Intracellular / Duodenum" />
         </Tags>
         <Children>
-          <Container id="jiTU8UnI80Ked3g1erXRMw" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="xvj8Scr9A0-2VTktw89RqQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="mAfUYZGb_EuDmoTtAiKKGQ" name="Periportal_bc_Pericentral_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="c0pnnkb11EiaOMW4lLDk1A" secondNeighbor="2TFwQut18EW9kWzFwrTU8w">
-        <Children>
-          <Container id="iw9C8uWKH0mqdi1S1_ml9Q" name="MoleculeProperties" mode="Logical" containerType="Other" />
-        </Children>
-      </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="RJPC5Fdybk-Wy0fnHWtYvw" name="Periportal_pls_Pericentral_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="8DZXItaWrkqNKYuUKQ9tjQ" secondNeighbor="HxgZ7x9ayUa9QQjSKC8a0g">
-        <Children>
-          <Container id="VtwGAsguQ0Sz3qFf3IDkfw" name="MoleculeProperties" mode="Logical" containerType="Other" />
-        </Children>
-      </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="hl1TGbsqJEaJXTuU3CA1QA" name="ArterialBlood_bc_Periportal_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="b_JwGFelbkeRco3dQKg62Q" secondNeighbor="c0pnnkb11EiaOMW4lLDk1A">
+      <NeighborhoodBuilder id="FNjnzNdPlkiFQ3pqVtHKYg" name="Periportal_cell_Lumen_duo" mode="Logical" containerType="Neighborhood" firstNeighbor="m3iM2eCzCE-IODPwxB9WGQ" secondNeighbor="Q2OaqR8Xk0-oRedeXkkAcA">
         <Tags>
-          <Tag value="Neighborhood: BloodCells / BloodCells" />
+          <Tag value="Neighborhood: Intracellular / Duodenum" />
         </Tags>
         <Children>
-          <Container id="7bO2kztiL0mLz3iIslB_Ew" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="W3NnO18nX06X203kubgRMA" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
     </Children>
   </NeighborhoodsContainer>
   <FormulaCache>
     <Formulas>
-      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_MucosaPermeabilityScaleFactor_trans" name="PARAM_MucosaPermeabilityScaleFactor_trans" formula="P_int_trans_default &gt;0 ? P_int_trans / P_int_trans_default : 0">
+      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_default" name="PARAM_P_int_default" dim="Velocity" formula="10 ^ (m * log10 (P_int_InVitro) + b)">
         <Paths>
           <Path path="0" as="1" dim="2" />
-          <Path path="3" as="4" dim="2" />
+          <Path path="3" as="4" />
+          <Path path="5" as="6" />
         </Paths>
       </Formula>
-      <BlackBoxFormula id="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" name="PARTITION COEFFICIENT FORMULA" />
-      <BlackBoxFormula id="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" name="CELLULAR PERMEABILITY FACTOR RATE" />
-      <Formula id="DiffusionCommon_PKSim.PARAM_P_rbc_pls" name="PARAM_P_rbc_pls" dim="Velocity" formula="P * P_rbc_pls_factor">
+      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_P_int" name="PARAM_P_int" dim="Velocity" formula="10 ^ (m * log10 (P_int_InVitro) + b)">
         <Paths>
+          <Path path="3" as="4" />
           <Path path="5" as="6" />
-          <Path path="7" as="8" dim="2" />
+          <Path path="7" as="1" dim="2" />
         </Paths>
       </Formula>
-      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_P_int" name="PARAM_P_int" dim="Velocity" formula="10 ^ (m * log10 (P_int_InVitro) + b)">
+      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_MucosaPermeabilityScaleFactor_trans" name="PARAM_MucosaPermeabilityScaleFactor_trans" formula="P_int_trans_default &gt;0 ? P_int_trans / P_int_trans_default : 0">
         <Paths>
-          <Path path="9" as="10" />
-          <Path path="11" as="12" />
-          <Path path="13" as="14" dim="2" />
+          <Path path="8" as="9" dim="2" />
+          <Path path="10" as="11" dim="2" />
         </Paths>
       </Formula>
-      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_default" name="PARAM_P_int_default" dim="Velocity" formula="10 ^ (m * log10 (P_int_InVitro) + b)">
+      <Formula id="DiffusionCommon_PKSim.PARAM_P_rbc_pls" name="PARAM_P_rbc_pls" dim="Velocity" formula="P * P_rbc_pls_factor">
         <Paths>
-          <Path path="15" as="14" dim="2" />
-          <Path path="9" as="10" />
-          <Path path="11" as="12" />
+          <Path path="12" as="13" />
+          <Path path="14" as="15" dim="2" />
         </Paths>
       </Formula>
       <Formula id="DiffusionCommon_PKSim.PARAM_P_pls_rbc" name="PARAM_P_pls_rbc" dim="Velocity" formula="P * P_pls_rbc_factor">
         <Paths>
           <Path path="16" as="17" />
-          <Path path="7" as="8" dim="2" />
+          <Path path="14" as="15" dim="2" />
         </Paths>
       </Formula>
+      <BlackBoxFormula id="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" name="CELLULAR PERMEABILITY FACTOR RATE" />
+      <BlackBoxFormula id="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" name="PARTITION COEFFICIENT FORMULA" />
       <Formula id="DistributionInVitro_PKSim.PARAM_fu" name="PARAM_fu" dim="Fraction" formula="1 / (1 + (BindingPartner = Albumin ? AlbuminOntgenyFactor : (BindingPartner = Agp ? AgpOntogenyFactor : 1) ) * (1 - fu_ref) / fu_ref) * PlasmaProteinScaleFactor">
         <Paths>
           <Path path="18" as="19" />
@@ -23162,54 +23235,46 @@
           <Path path="46" as="47" />
         </Paths>
       </Formula>
-      <Formula id="Individual_PKSim.PARAM_VolumePlasma" name="PARAM_VolumePlasma" dim="Volume" formula="V_pls_art+V_pls_bon+V_pls_brn+V_pls_cae+V_pls_colasc+V_pls_coldesc+V_pls_colsigm+V_pls_coltrans+V_pls_duo+V_pls_fat+V_pls_tes+V_pls_hrt+V_pls_kid+V_pls_lin+V_pls_lil+V_pls_lje+V_pls_lng+V_pls_mus+V_pls_pan+V_pls_prc+V_pls_prp+V_pls_pve+V_pls_rect+V_pls_skn+V_pls_sin+V_pls_spl+V_pls_sto+V_pls_uil+V_pls_uje+V_pls_ven">
+      <Formula id="Individual_PKSim.PARAM_CLSpec_endosomal_global" name="PARAM_CLSpec_endosomal_global" dim="Inversed time" formula="K_uptake-K_rec&gt;=0 ? K_uptake-K_rec : 0">
         <Paths>
           <Path path="48" as="49" dim="50" />
           <Path path="51" as="52" dim="50" />
-          <Path path="53" as="54" dim="50" />
-          <Path path="55" as="56" dim="50" />
-          <Path path="57" as="58" dim="50" />
-          <Path path="59" as="60" dim="50" />
-          <Path path="61" as="62" dim="50" />
-          <Path path="63" as="64" dim="50" />
-          <Path path="65" as="66" dim="50" />
-          <Path path="67" as="68" dim="50" />
-          <Path path="69" as="70" dim="50" />
-          <Path path="71" as="72" dim="50" />
-          <Path path="73" as="74" dim="50" />
-          <Path path="75" as="76" dim="50" />
-          <Path path="77" as="78" dim="50" />
-          <Path path="79" as="80" dim="50" />
-          <Path path="81" as="82" dim="50" />
-          <Path path="83" as="84" dim="50" />
-          <Path path="85" as="86" dim="50" />
-          <Path path="87" as="88" dim="50" />
-          <Path path="89" as="90" dim="50" />
-          <Path path="91" as="92" dim="50" />
-          <Path path="93" as="94" dim="50" />
-          <Path path="95" as="96" dim="50" />
-          <Path path="97" as="98" dim="50" />
-          <Path path="99" as="100" dim="50" />
-          <Path path="101" as="102" dim="50" />
-          <Path path="103" as="104" dim="50" />
-          <Path path="105" as="106" dim="50" />
-          <Path path="107" as="108" dim="50" />
         </Paths>
       </Formula>
-      <Formula id="Individual_PKSim.PARAM_CLSpec_endosomal_global" name="PARAM_CLSpec_endosomal_global" dim="Inversed time" formula="K_uptake-K_rec&gt;=0 ? K_uptake-K_rec : 0">
+      <Formula id="Individual_PKSim.PARAM_VolumePlasma" name="PARAM_VolumePlasma" dim="Volume" formula="V_pls_art+V_pls_bon+V_pls_brn+V_pls_cae+V_pls_colasc+V_pls_coldesc+V_pls_colsigm+V_pls_coltrans+V_pls_duo+V_pls_fat+V_pls_tes+V_pls_hrt+V_pls_kid+V_pls_lin+V_pls_lil+V_pls_lje+V_pls_lng+V_pls_mus+V_pls_pan+V_pls_prc+V_pls_prp+V_pls_pve+V_pls_rect+V_pls_skn+V_pls_sin+V_pls_spl+V_pls_sto+V_pls_uil+V_pls_uje+V_pls_ven">
         <Paths>
-          <Path path="109" as="110" dim="111" />
-          <Path path="112" as="113" dim="111" />
+          <Path path="53" as="54" dim="55" />
+          <Path path="56" as="57" dim="55" />
+          <Path path="58" as="59" dim="55" />
+          <Path path="60" as="61" dim="55" />
+          <Path path="62" as="63" dim="55" />
+          <Path path="64" as="65" dim="55" />
+          <Path path="66" as="67" dim="55" />
+          <Path path="68" as="69" dim="55" />
+          <Path path="70" as="71" dim="55" />
+          <Path path="72" as="73" dim="55" />
+          <Path path="74" as="75" dim="55" />
+          <Path path="76" as="77" dim="55" />
+          <Path path="78" as="79" dim="55" />
+          <Path path="80" as="81" dim="55" />
+          <Path path="82" as="83" dim="55" />
+          <Path path="84" as="85" dim="55" />
+          <Path path="86" as="87" dim="55" />
+          <Path path="88" as="89" dim="55" />
+          <Path path="90" as="91" dim="55" />
+          <Path path="92" as="93" dim="55" />
+          <Path path="94" as="95" dim="55" />
+          <Path path="96" as="97" dim="55" />
+          <Path path="98" as="99" dim="55" />
+          <Path path="100" as="101" dim="55" />
+          <Path path="102" as="103" dim="55" />
+          <Path path="104" as="105" dim="55" />
+          <Path path="106" as="107" dim="55" />
+          <Path path="108" as="109" dim="55" />
+          <Path path="110" as="111" dim="55" />
+          <Path path="112" as="113" dim="55" />
         </Paths>
       </Formula>
-      <SumFormula id="DynamicSumFormulas.PARAM_Tissue_Organs_Weight" name="PARAM_Tissue_Organs_Weight" dim="Mass" variable="P" formulaString="P_#i">
-        <Criteria>
-          <DescriptorConditions>
-            <MatchTagCondition tag="TissueOrgan" />
-            <MatchTagCondition tag="Weight (tissue)" />
-          </DescriptorConditions>
-        </Criteria>
-      </SumFormula>
       <Formula id="Individual_PKSim.PARAM_BW" name="PARAM_BW" dim="Mass" formula="Weight_blood + Weight_tissue">
         <Paths>
           <Path path="114" as="115" dim="116" />
@@ -23224,6 +23289,14 @@
           </DescriptorConditions>
         </Criteria>
       </SumFormula>
+      <SumFormula id="DynamicSumFormulas.PARAM_Tissue_Organs_Weight" name="PARAM_Tissue_Organs_Weight" dim="Mass" variable="P" formulaString="P_#i">
+        <Criteria>
+          <DescriptorConditions>
+            <MatchTagCondition tag="TissueOrgan" />
+            <MatchTagCondition tag="Weight (tissue)" />
+          </DescriptorConditions>
+        </Criteria>
+      </SumFormula>
       <Formula id="GFR_Calculation.PARAM_PostMenstrualAge" name="PARAM_PostMenstrualAge" dim="Age in weeks" formula="Age* 365.25/7 + GA">
         <Paths>
           <Path path="119" as="120" dim="121" />
@@ -23245,18 +23318,18 @@
       <Formula id="Individual_PKSim.PARAM_Tissue_Weight" name="PARAM_Tissue_Weight" dim="Mass" formula="Volume * Density">
         <Paths>
           <Path path="132" as="133" dim="133" />
-          <Path path="134" as="50" dim="50" />
+          <Path path="134" as="55" dim="55" />
         </Paths>
       </Formula>
       <Formula id="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" name="PARAM_ProteinContainerVolume_Compartment" dim="Volume" formula="Volume">
         <Paths>
-          <Path path="134" as="50" dim="50" />
+          <Path path="134" as="55" dim="55" />
         </Paths>
       </Formula>
       <Formula id="CompartmentsVolume_2Poren.VOLUME_pls_BloodOrgan_2Pores" name="VOLUME_pls_BloodOrgan_2Pores" dim="Volume" formula="(1-HCT)*V">
         <Paths>
           <Path path="135" as="136" />
-          <Path path="137" as="138" dim="50" />
+          <Path path="137" as="138" dim="55" />
           <Path path="40" as="41" />
         </Paths>
       </Formula>
@@ -23282,7 +23355,7 @@
       </Formula>
       <Formula id="CompartmentsVolume_2Poren.VOLUME_bc_blood_organ_2Pores" name="VOLUME_bc_blood_organ_2Pores" dim="Volume" formula="HCT*V">
         <Paths>
-          <Path path="137" as="138" dim="50" />
+          <Path path="137" as="138" dim="55" />
           <Path path="40" as="41" />
         </Paths>
       </Formula>
@@ -23302,19 +23375,19 @@
           <Path path="151" as="152" dim="24" />
         </Paths>
       </Formula>
-      <Formula id="EndosomalSpaceBindingFormulas.PARAM_K_rec" name="PARAM_K_rec" dim="Inversed time" formula="Rrec_global">
+      <Formula id="EndosomalSpaceBindingFormulas.PARAM_f_rec_vas" name="PARAM_f_rec_vas" dim="Fraction" formula="f_rec_vas_global">
         <Paths>
-          <Path path="112" as="153" dim="111" />
+          <Path path="153" as="154" dim="24" />
         </Paths>
       </Formula>
       <Formula id="EndosomalSpaceBindingFormulas.PARAM_K_uptake" name="PARAM_K_uptake" dim="Inversed time" formula="Rendo_v_global">
         <Paths>
-          <Path path="109" as="154" dim="111" />
+          <Path path="48" as="155" dim="50" />
         </Paths>
       </Formula>
-      <Formula id="EndosomalSpaceBindingFormulas.PARAM_f_rec_vas" name="PARAM_f_rec_vas" dim="Fraction" formula="f_rec_vas_global">
+      <Formula id="EndosomalSpaceBindingFormulas.PARAM_K_rec" name="PARAM_K_rec" dim="Inversed time" formula="Rrec_global">
         <Paths>
-          <Path path="155" as="156" dim="24" />
+          <Path path="51" as="156" dim="50" />
         </Paths>
       </Formula>
       <Formula id="Individual_PKSim.PARAM_Q_from_Qspec" name="PARAM_Q_from_Qspec" dim="Flow" formula="Qspec * Weight">
@@ -23328,8 +23401,8 @@
           <Path path="162" as="163" />
           <Path path="164" as="165" />
           <Path path="166" as="167" dim="168" />
-          <Path path="169" as="170" dim="50" />
-          <Path path="134" as="138" dim="50" />
+          <Path path="169" as="170" dim="55" />
+          <Path path="134" as="138" dim="55" />
           <Path path="171" as="172" />
         </Paths>
       </Formula>
@@ -23360,14 +23433,14 @@
       <Formula id="CompartmentsVolume_2Poren.VOLUME_pls_2Pores" name="VOLUME_pls_2Pores" dim="Volume" formula="f_vas*(1-HCT)*V_org">
         <Paths>
           <Path path="135" as="136" />
-          <Path path="137" as="187" dim="50" />
+          <Path path="137" as="187" dim="55" />
           <Path path="40" as="41" />
         </Paths>
       </Formula>
       <Formula id="CompartmentsVolume_2Poren.VOLUME_bc_2Pores" name="VOLUME_bc_2Pores" dim="Volume" formula="f_vas*HCT*V">
         <Paths>
           <Path path="135" as="136" />
-          <Path path="137" as="138" dim="50" />
+          <Path path="137" as="138" dim="55" />
           <Path path="40" as="41" />
         </Paths>
       </Formula>
@@ -23379,7 +23452,7 @@
       <Formula id="CompartmentsVolume_2Poren.VOLUME_int_2Pores" name="VOLUME_int_2Pores" dim="Volume" formula="f_int*V">
         <Paths>
           <Path path="189" as="183" />
-          <Path path="137" as="138" dim="50" />
+          <Path path="137" as="138" dim="55" />
         </Paths>
       </Formula>
       <Formula id="Individual_PKSim.PARAM_pH_INT" name="PARAM_pH_INT" formula="pH_int">
@@ -23394,13 +23467,13 @@
       </Formula>
       <Formula id="CompoundCommon.PARAM_ProteinContainerVolume_Organ" name="PARAM_ProteinContainerVolume_Organ" dim="Volume" formula="Volume">
         <Paths>
-          <Path path="137" as="50" dim="50" />
+          <Path path="137" as="55" dim="55" />
         </Paths>
       </Formula>
       <Formula id="CompartmentsVolume_2Poren.VOLUME_cell_2Pores" name="VOLUME_cell_2Pores" dim="Volume" formula="f_cell*V">
         <Paths>
           <Path path="194" as="195" />
-          <Path path="137" as="138" dim="50" />
+          <Path path="137" as="138" dim="55" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_bon" name="PARAM_K_Water_CELL_bon" formula="K_water_cell">
@@ -23529,30 +23602,30 @@
           <Path path="216" as="180" dim="181" />
         </Paths>
       </Formula>
-      <Formula id="Renal_Aging_Human.Renal aging factor" name="Renal aging factor" formula="Age &lt;= Age_onset ? 1 : 1 - Decrease_Factor*(Age-Age_onset)^Hill/(TA50^Hill+(Age-Age_onset)^Hill)">
+      <Formula id="GFR_Calculation.PARAM_GFR" name="PARAM_GFR" dim="Flow" formula="GFRspec * Weight_Kidney">
         <Paths>
-          <Path path="217" as="120" dim="121" />
-          <Path path="218" as="219" dim="121" />
-          <Path path="220" as="221" dim="121" />
-          <Path path="222" as="223" />
-          <Path path="224" as="225" />
+          <Path path="217" as="218" dim="159" />
+          <Path path="219" as="220" dim="116" />
         </Paths>
       </Formula>
-      <Formula id="GFR_Calculation.PARAM_GFR" name="PARAM_GFR" dim="Flow" formula="GFRspec * Weight_Kidney">
+      <Formula id="GFR_Calculation.PARAM_GFR_Spec" name="PARAM_GFR_Spec" dim="Flow per weight organ" formula="(PMA^Hill/(TM50^Hill+PMA^Hill)*(1-GFR_premat)+GFR_premat) * GFR_mat / V_kid_std * Renal_aging_scaling_factor">
         <Paths>
-          <Path path="226" as="227" dim="159" />
-          <Path path="228" as="229" dim="116" />
+          <Path path="221" as="222" dim="124" />
+          <Path path="223" as="224" dim="168" />
+          <Path path="225" as="226" />
+          <Path path="227" as="228" />
+          <Path path="229" as="230" dim="124" />
+          <Path path="231" as="232" dim="55" />
+          <Path path="233" as="234" />
         </Paths>
       </Formula>
-      <Formula id="GFR_Calculation.PARAM_GFR_Spec" name="PARAM_GFR_Spec" dim="Flow per weight organ" formula="(PMA^Hill/(TM50^Hill+PMA^Hill)*(1-GFR_premat)+GFR_premat) * GFR_mat / V_kid_std * Renal_aging_scaling_factor">
+      <Formula id="Renal_Aging_Human.Renal aging factor" name="Renal aging factor" formula="Age &lt;= Age_onset ? 1 : 1 - Decrease_Factor*(Age-Age_onset)^Hill/(TA50^Hill+(Age-Age_onset)^Hill)">
         <Paths>
-          <Path path="230" as="231" dim="124" />
-          <Path path="232" as="233" />
-          <Path path="234" as="235" dim="168" />
-          <Path path="236" as="223" />
-          <Path path="237" as="238" />
-          <Path path="239" as="240" dim="124" />
-          <Path path="241" as="242" dim="50" />
+          <Path path="235" as="120" dim="121" />
+          <Path path="236" as="237" dim="121" />
+          <Path path="238" as="239" dim="121" />
+          <Path path="240" as="226" />
+          <Path path="241" as="242" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_kid" name="PARAM_K_Water_INT_kid" formula="K_water_int">
@@ -23579,8 +23652,8 @@
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_FillLevel" name="PARAM_FillLevel" formula="Liquid/V">
         <Paths>
-          <Path path="247" as="248" dim="50" />
-          <Path path="134" as="138" dim="50" />
+          <Path path="247" as="248" dim="55" />
+          <Path path="134" as="138" dim="55" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_Area" name="PARAM_Area" dim="Area" formula="PI*(r1+r2)*L">
@@ -23598,7 +23671,7 @@
       <Formula id="Lumen_PKSim.PARAM_Liquid_StartValue" name="PARAM_Liquid_StartValue" dim="Volume" formula="V*SteadyStateFillLevel">
         <Paths>
           <Path path="257" as="258" dim="24" />
-          <Path path="134" as="138" dim="50" />
+          <Path path="134" as="138" dim="55" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.LiquidRHS_sto" name="LiquidRHS_sto" dim="Flow" formula="OralApplicationsEnabled ? -LT_sto + Inflow*FillLevelFlag : 0">
@@ -23611,16 +23684,21 @@
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_LiquidTransferRate_sto" name="PARAM_LiquidTransferRate_sto" dim="Flow" formula="w*Liquid*FillLevelFlagNext">
         <Paths>
-          <Path path="267" as="268" dim="111" />
-          <Path path="247" as="248" dim="50" />
+          <Path path="267" as="268" dim="50" />
+          <Path path="247" as="248" dim="55" />
           <Path path="269" as="270" />
         </Paths>
       </Formula>
+      <Formula id="Lumen_PKSim.PARAM_pH_from_pH_fasted" name="PARAM_pH_from_pH_fasted" formula="pH_fasted">
+        <Paths>
+          <Path path="271" as="272" />
+        </Paths>
+      </Formula>
       <Formula id="Lumen_PKSim.PARAM_Inflow_Stomach" name="PARAM_Inflow_Stomach" dim="Flow" formula="SteadyStateFillLevel*V/StomachInflowTime">
         <Paths>
           <Path path="257" as="258" dim="24" />
-          <Path path="271" as="272" dim="146" />
-          <Path path="134" as="138" dim="50" />
+          <Path path="273" as="274" dim="146" />
+          <Path path="134" as="138" dim="55" />
           <TimePath />
         </Paths>
       </Formula>
@@ -23633,98 +23711,93 @@
       </Formula>
       <Formula id="MucosaVolume.PARAM_VolumeGutWall" name="PARAM_VolumeGutWall" dim="Volume" formula="Area*d">
         <Paths>
-          <Path path="273" as="181" dim="181" />
-          <Path path="274" as="275" dim="127" />
-        </Paths>
-      </Formula>
-      <Formula id="Lumen_PKSim.PARAM_pH_from_pH_fasted" name="PARAM_pH_from_pH_fasted" formula="pH_fasted">
-        <Paths>
-          <Path path="276" as="277" />
-        </Paths>
-      </Formula>
-      <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" name="PARAM_pKa_pH_WS_lum_ForSol_K1" formula="F1*F2*F3">
-        <Paths>
-          <Path path="278" as="279" />
-          <Path path="280" as="281" />
-          <Path path="282" as="283" />
+          <Path path="275" as="181" dim="181" />
+          <Path path="276" as="277" dim="127" />
         </Paths>
       </Formula>
       <Formula id="CompoundCommon.PARAM_OntogenyFactor_FromGlobal_GI" name="PARAM_OntogenyFactor_FromGlobal_GI" formula="f_onto">
         <Paths>
-          <Path path="284" as="143" />
+          <Path path="278" as="143" />
         </Paths>
       </Formula>
       <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" name="PARAM_pKa_pH_WS_lum_ForSol_F1" formula="CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1">
         <Paths>
+          <Path path="279" as="280" />
+          <Path path="281" as="282" />
+          <Path path="283" as="284" />
           <Path path="285" as="286" />
-          <Path path="287" as="288" />
-          <Path path="289" as="290" />
-          <Path path="291" as="292" />
         </Paths>
       </Formula>
       <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" name="PARAM_pKa_pH_WS_lum_ForSol_F2" formula="CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1">
         <Paths>
-          <Path path="293" as="294" />
+          <Path path="279" as="280" />
           <Path path="287" as="288" />
-          <Path path="295" as="296" />
-          <Path path="291" as="292" />
+          <Path path="289" as="290" />
+          <Path path="285" as="286" />
         </Paths>
       </Formula>
       <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" name="PARAM_pKa_pH_WS_lum_ForSol_F3" formula="CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1">
         <Paths>
+          <Path path="279" as="280" />
+          <Path path="291" as="292" />
+          <Path path="293" as="294" />
+          <Path path="285" as="286" />
+        </Paths>
+      </Formula>
+      <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" name="PARAM_pKa_pH_WS_lum_ForSol_K1" formula="F1*F2*F3">
+        <Paths>
+          <Path path="295" as="296" />
           <Path path="297" as="298" />
-          <Path path="287" as="288" />
           <Path path="299" as="300" />
-          <Path path="291" as="292" />
         </Paths>
       </Formula>
       <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" name="PARAM_pKa_pH_WS_lum_ForSol_K2" formula="(1-F1)*F2*F3">
         <Paths>
-          <Path path="278" as="279" />
-          <Path path="280" as="281" />
-          <Path path="282" as="283" />
+          <Path path="295" as="296" />
+          <Path path="297" as="298" />
+          <Path path="299" as="300" />
         </Paths>
       </Formula>
       <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" name="PARAM_pKa_pH_WS_lum_ForSol_K3" formula="F1*(1-F2)*F3">
         <Paths>
-          <Path path="278" as="279" />
-          <Path path="280" as="281" />
-          <Path path="282" as="283" />
+          <Path path="295" as="296" />
+          <Path path="297" as="298" />
+          <Path path="299" as="300" />
         </Paths>
       </Formula>
       <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" name="PARAM_pKa_pH_WS_lum_ForSol_K4" formula="F1*F2*(1-F3)">
         <Paths>
-          <Path path="278" as="279" />
-          <Path path="280" as="281" />
-          <Path path="282" as="283" />
+          <Path path="295" as="296" />
+          <Path path="297" as="298" />
+          <Path path="299" as="300" />
         </Paths>
       </Formula>
       <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" name="PARAM_pKa_pH_WS_lum_ForSol_K5" formula="(1-F1)*(1-F2)*F3">
         <Paths>
-          <Path path="278" as="279" />
-          <Path path="280" as="281" />
-          <Path path="282" as="283" />
+          <Path path="295" as="296" />
+          <Path path="297" as="298" />
+          <Path path="299" as="300" />
         </Paths>
       </Formula>
       <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" name="PARAM_pKa_pH_WS_lum_ForSol_K6" formula="(1-F1)*F2*(1-F3)">
         <Paths>
-          <Path path="278" as="279" />
-          <Path path="280" as="281" />
-          <Path path="282" as="283" />
+          <Path path="295" as="296" />
+          <Path path="297" as="298" />
+          <Path path="299" as="300" />
         </Paths>
       </Formula>
       <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" name="PARAM_pKa_pH_WS_lum_ForSol_K7" formula="F1*(1-F2)*(1-F3)">
         <Paths>
-          <Path path="278" as="279" />
-          <Path path="280" as="281" />
-          <Path path="282" as="283" />
+          <Path path="295" as="296" />
+          <Path path="297" as="298" />
+          <Path path="299" as="300" />
         </Paths>
       </Formula>
       <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" name="PARAM_pKa_pH_WS_lum_ForSol_K8" formula="(1-F1)*(1-F2)*(1-F3)">
         <Paths>
-          <Path path="278" as="279" />
-          <Path path="280" as="281" />
-          <Path path="282" as="283" />
+          <Path path="295" as="296" />
+          <Path path="297" as="298" />
+          <Path path="299" as="300" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_IntestinalSolubility" name="PARAM_IntestinalSolubility" dim="Concentration (mass)" formula="Solubility * Solubility_pKa_REFpH_Factor / Solubility_pKa_pH_Factor + SolubilityTable">
@@ -23738,7 +23811,7 @@
       <TableFormulaWithXArgument id="Lumen_PKSim.TableFormulaWithXArgument_SolubilityTable" name="TableFormulaWithXArgument_SolubilityTable" dim="Concentration (mass)" tableObjectAlias="Table" xArgumentAlias="XArg">
         <Paths>
           <Path path="310" as="311" dim="303" />
-          <Path path="291" as="312" />
+          <Path path="285" as="312" />
         </Paths>
       </TableFormulaWithXArgument>
       <Formula id="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" name="PARAM_Solubility_pKa_pH_Factor" formula="K1+K2/base^(CT0^2)+K3/base^(CT1^2)+K4/base^(CT2^2)+K5/base^max(CT0+CT1;-CT0-CT1)+K6/base^max(CT0+CT2;-CT0-CT2)+K7/base^max(CT1+CT2;-CT1-CT2)+K8/base^max(CT0+CT1+CT2;-CT0-CT1-CT2)">
@@ -23751,9 +23824,9 @@
           <Path path="323" as="324" />
           <Path path="325" as="326" />
           <Path path="327" as="328" />
-          <Path path="285" as="286" />
-          <Path path="293" as="294" />
-          <Path path="297" as="298" />
+          <Path path="281" as="282" />
+          <Path path="287" as="288" />
+          <Path path="291" as="292" />
           <Path path="329" as="330" />
         </Paths>
       </Formula>
@@ -23762,1760 +23835,1760 @@
           <Path path="331" as="145" dim="146" />
         </Paths>
       </Formula>
+      <Formula id="Lumen_PKSim.PARAM_EffectiveLumenConcentration" name="PARAM_EffectiveLumenConcentration" dim="Concentration (molar)" formula="EnableSupersaturarion ? M/Liquid : min(Solubility/MW ; M/Liquid)">
+        <Paths>
+          <Path path="332" as="333" dim="334" />
+          <Path path="335" as="307" dim="303" />
+          <Path path="336" as="337" />
+          <Path path="338" as="339" dim="340" />
+          <Path path="341" as="248" dim="55" />
+        </Paths>
+      </Formula>
+      <Formula id="Lumen_PKSim.PARAM_Outflow_Duodenum" name="PARAM_Outflow_Duodenum" dim="Inversed time" formula="(k_p*alpha_p*V_p+inflow-k*alpha*V)/(alpha*V)">
+        <Paths>
+          <Path path="257" as="342" dim="24" />
+          <Path path="267" as="343" dim="50" />
+          <Path path="263" as="344" dim="168" />
+          <Path path="134" as="138" dim="55" />
+          <Path path="345" as="346" dim="24" />
+          <Path path="347" as="348" dim="50" />
+          <Path path="349" as="350" dim="55" />
+        </Paths>
+      </Formula>
+      <Formula id="Lumen_Geometry.PARAM_Lumen_Geometry_R2" name="PARAM_Lumen_Geometry_R2" dim="Length" formula="r2_p0 + Height*r2_p1">
+        <Paths>
+          <Path path="351" as="126" dim="127" />
+          <Path path="352" as="353" dim="127" />
+          <Path path="354" as="355" />
+        </Paths>
+      </Formula>
+      <Formula id="Lumen_PKSim.PARAM_EffectiveSurfaceArea" name="PARAM_EffectiveSurfaceArea" dim="Area" formula="Ageom*AeffFactor*AeffVariabilityFactor">
+        <Paths>
+          <Path path="356" as="357" />
+          <Path path="275" as="358" dim="181" />
+          <Path path="359" as="360" />
+        </Paths>
+      </Formula>
       <Formula id="Lumen_PKSim.PARAM_InverseSITT_Factor_Duodenum" name="PARAM_InverseSITT_Factor_Duodenum" dim="Inversed time" formula="LuminalVelocity/SITT_fact">
         <Paths>
-          <Path path="332" as="333" dim="111" />
-          <Path path="334" as="335" />
+          <Path path="361" as="362" dim="50" />
+          <Path path="363" as="364" />
         </Paths>
       </Formula>
       <Formula id="Lumen_Geometry.PARAM_Lumen_Geometry_Length" name="PARAM_Lumen_Geometry_Length" dim="Length" formula="L_p0 + Height*L_p1">
         <Paths>
-          <Path path="336" as="126" dim="127" />
-          <Path path="337" as="338" dim="127" />
-          <Path path="339" as="340" />
+          <Path path="351" as="126" dim="127" />
+          <Path path="365" as="366" dim="127" />
+          <Path path="367" as="368" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.LiquidRHS_duo" name="LiquidRHS_duo" dim="Flow" formula="OralApplicationsEnabled ? LT_sto - LT_duo + Inflow*FillLevelFlag - Outflow*Liquid : 0">
         <Paths>
-          <Path path="341" as="342" dim="111" />
+          <Path path="369" as="370" dim="50" />
           <Path path="259" as="260" />
-          <Path path="247" as="248" dim="50" />
-          <Path path="261" as="343" dim="168" />
+          <Path path="247" as="248" dim="55" />
+          <Path path="261" as="371" dim="168" />
           <Path path="263" as="264" dim="168" />
           <Path path="265" as="266" />
-          <Path path="344" as="262" dim="168" />
+          <Path path="372" as="262" dim="168" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_LiquidTransferRate_duo" name="PARAM_LiquidTransferRate_duo" dim="Flow" formula="w*Liquid*FillLevelFlagNext">
         <Paths>
-          <Path path="267" as="268" dim="111" />
-          <Path path="247" as="248" dim="50" />
-          <Path path="345" as="270" />
+          <Path path="267" as="268" dim="50" />
+          <Path path="247" as="248" dim="55" />
+          <Path path="373" as="270" />
         </Paths>
       </Formula>
       <Formula id="Lumen_Geometry.PARAM_Lumen_Geometry_R1" name="PARAM_Lumen_Geometry_R1" dim="Length" formula="r1_p0 + Height*r1_p1">
         <Paths>
-          <Path path="336" as="126" dim="127" />
-          <Path path="346" as="347" dim="127" />
-          <Path path="348" as="349" />
+          <Path path="351" as="126" dim="127" />
+          <Path path="374" as="375" dim="127" />
+          <Path path="376" as="377" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_Inflow_Duodenum" name="PARAM_Inflow_Duodenum" dim="Flow" formula="0.02894*V">
         <Paths>
-          <Path path="134" as="138" dim="50" />
+          <Path path="134" as="138" dim="55" />
         </Paths>
       </Formula>
       <Formula id="Lumen_Geometry.PARAM_Lumen_Geometry_Thickness" name="PARAM_Lumen_Geometry_Thickness" dim="Length" formula="Thickness_p1 + Thickness_p2*(1-exp(Thickness_p3*Height))">
         <Paths>
-          <Path path="336" as="126" dim="127" />
-          <Path path="350" as="351" dim="127" />
-          <Path path="352" as="353" dim="127" />
-          <Path path="354" as="355" dim="356" />
+          <Path path="351" as="126" dim="127" />
+          <Path path="378" as="379" dim="127" />
+          <Path path="380" as="381" dim="127" />
+          <Path path="382" as="383" dim="384" />
         </Paths>
       </Formula>
       <Formula id="MucosaVolume_Human.PARAM_VolumeGutWall_Duodenum" name="PARAM_VolumeGutWall_Duodenum" dim="Volume" formula="V_Intestine * 0.087">
         <Paths>
-          <Path path="357" as="358" dim="50" />
-        </Paths>
-      </Formula>
-      <Formula id="Lumen_PKSim.PARAM_Outflow_Duodenum" name="PARAM_Outflow_Duodenum" dim="Inversed time" formula="(k_p*alpha_p*V_p+inflow-k*alpha*V)/(alpha*V)">
-        <Paths>
-          <Path path="257" as="359" dim="24" />
-          <Path path="267" as="360" dim="111" />
-          <Path path="263" as="361" dim="168" />
-          <Path path="134" as="138" dim="50" />
-          <Path path="362" as="363" dim="24" />
-          <Path path="364" as="365" dim="111" />
-          <Path path="366" as="367" dim="50" />
-        </Paths>
-      </Formula>
-      <Formula id="Lumen_Geometry.PARAM_Lumen_Geometry_R2" name="PARAM_Lumen_Geometry_R2" dim="Length" formula="r2_p0 + Height*r2_p1">
-        <Paths>
-          <Path path="336" as="126" dim="127" />
-          <Path path="368" as="369" dim="127" />
-          <Path path="370" as="371" />
-        </Paths>
-      </Formula>
-      <Formula id="Lumen_PKSim.PARAM_EffectiveSurfaceArea" name="PARAM_EffectiveSurfaceArea" dim="Area" formula="Ageom*AeffFactor*AeffVariabilityFactor">
-        <Paths>
-          <Path path="372" as="373" />
-          <Path path="273" as="374" dim="181" />
-          <Path path="375" as="376" />
+          <Path path="385" as="386" dim="55" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_duo" name="PARAM_OralMassAbsorbed_RHS_duo" dim="Amount per time" formula="PassiveRates_para+PassiveRates_trans-(ActiveRates_para+ActiveRates_trans)">
         <Paths>
-          <Path path="377" as="378" dim="379" />
-          <Path path="380" as="381" dim="379" />
-          <Path path="382" as="383" dim="379" />
-          <Path path="384" as="385" dim="379" />
+          <Path path="387" as="388" dim="389" />
+          <Path path="390" as="391" dim="389" />
+          <Path path="392" as="393" dim="389" />
+          <Path path="394" as="395" dim="389" />
         </Paths>
       </Formula>
-      <Formula id="Lumen_PKSim.PARAM_InverseSITT_Factor_UpperJejunum" name="PARAM_InverseSITT_Factor_UpperJejunum" dim="Inversed time" formula="LuminalVelocity/SITT_fact">
+      <Formula id="Lumen_PKSim.PARAM_Outflow_UpperJejunum" name="PARAM_Outflow_UpperJejunum" dim="Inversed time" formula="(k_p*alpha_p*V_p+inflow-k*alpha*V)/(alpha*V)">
         <Paths>
-          <Path path="332" as="333" dim="111" />
-          <Path path="334" as="335" />
+          <Path path="257" as="342" dim="24" />
+          <Path path="267" as="343" dim="50" />
+          <Path path="263" as="344" dim="168" />
+          <Path path="134" as="138" dim="55" />
+          <Path path="396" as="346" dim="24" />
+          <Path path="397" as="348" dim="50" />
+          <Path path="398" as="350" dim="55" />
         </Paths>
       </Formula>
-      <Formula id="MucosaVolume_Human.PARAM_VolumeGutWall_UpperJejunum" name="PARAM_VolumeGutWall_UpperJejunum" dim="Volume" formula="V_Intestine * 0.249">
+      <Formula id="Lumen_PKSim.PARAM_InverseSITT_Factor_UpperJejunum" name="PARAM_InverseSITT_Factor_UpperJejunum" dim="Inversed time" formula="LuminalVelocity/SITT_fact">
         <Paths>
-          <Path path="357" as="358" dim="50" />
+          <Path path="361" as="362" dim="50" />
+          <Path path="363" as="364" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.LiquidRHS_uje" name="LiquidRHS_uje" dim="Flow" formula="OralApplicationsEnabled ? LT_duo - LT_uje + Inflow*FillLevelFlag - Outflow*Liquid : 0">
         <Paths>
-          <Path path="341" as="342" dim="111" />
+          <Path path="369" as="370" dim="50" />
           <Path path="259" as="260" />
-          <Path path="247" as="248" dim="50" />
-          <Path path="261" as="386" dim="168" />
+          <Path path="247" as="248" dim="55" />
+          <Path path="261" as="399" dim="168" />
           <Path path="263" as="264" dim="168" />
-          <Path path="387" as="343" dim="168" />
+          <Path path="400" as="371" dim="168" />
           <Path path="265" as="266" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_LiquidTransferRate_uje" name="PARAM_LiquidTransferRate_uje" dim="Flow" formula="w*Liquid*FillLevelFlagNext">
         <Paths>
-          <Path path="267" as="268" dim="111" />
-          <Path path="247" as="248" dim="50" />
-          <Path path="388" as="270" />
+          <Path path="267" as="268" dim="50" />
+          <Path path="247" as="248" dim="55" />
+          <Path path="401" as="270" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_Inflow_UpperJejunum" name="PARAM_Inflow_UpperJejunum" dim="Flow" formula="0.0031572*V">
         <Paths>
-          <Path path="134" as="138" dim="50" />
+          <Path path="134" as="138" dim="55" />
         </Paths>
       </Formula>
-      <Formula id="Lumen_PKSim.PARAM_Outflow_UpperJejunum" name="PARAM_Outflow_UpperJejunum" dim="Inversed time" formula="(k_p*alpha_p*V_p+inflow-k*alpha*V)/(alpha*V)">
+      <Formula id="MucosaVolume_Human.PARAM_VolumeGutWall_UpperJejunum" name="PARAM_VolumeGutWall_UpperJejunum" dim="Volume" formula="V_Intestine * 0.249">
         <Paths>
-          <Path path="257" as="359" dim="24" />
-          <Path path="267" as="360" dim="111" />
-          <Path path="263" as="361" dim="168" />
-          <Path path="134" as="138" dim="50" />
-          <Path path="389" as="363" dim="24" />
-          <Path path="390" as="365" dim="111" />
-          <Path path="391" as="367" dim="50" />
+          <Path path="385" as="386" dim="55" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_uje" name="PARAM_OralMassAbsorbed_RHS_uje" dim="Amount per time" formula="PassiveRates_para+PassiveRates_trans-(ActiveRates_para+ActiveRates_trans)">
         <Paths>
-          <Path path="392" as="378" dim="379" />
-          <Path path="393" as="381" dim="379" />
-          <Path path="394" as="383" dim="379" />
-          <Path path="395" as="385" dim="379" />
-        </Paths>
-      </Formula>
-      <Formula id="Lumen_PKSim.PARAM_Inflow_LowerJejunum" name="PARAM_Inflow_LowerJejunum" dim="Flow" formula="0.0025102*V">
-        <Paths>
-          <Path path="134" as="138" dim="50" />
+          <Path path="402" as="388" dim="389" />
+          <Path path="403" as="391" dim="389" />
+          <Path path="404" as="393" dim="389" />
+          <Path path="405" as="395" dim="389" />
         </Paths>
       </Formula>
-      <Formula id="MucosaVolume_Human.PARAM_VolumeGutWall_LowerJejunum" name="PARAM_VolumeGutWall_LowerJejunum" dim="Volume" formula="V_Intestine * 0.184">
+      <Formula id="Lumen_PKSim.PARAM_Outflow_LowerJejunum" name="PARAM_Outflow_LowerJejunum" dim="Inversed time" formula="(k_p*alpha_p*V_p+inflow-k*alpha*V)/(alpha*V)">
         <Paths>
-          <Path path="357" as="358" dim="50" />
+          <Path path="257" as="342" dim="24" />
+          <Path path="267" as="343" dim="50" />
+          <Path path="263" as="344" dim="168" />
+          <Path path="134" as="138" dim="55" />
+          <Path path="406" as="346" dim="24" />
+          <Path path="407" as="348" dim="50" />
+          <Path path="408" as="350" dim="55" />
         </Paths>
       </Formula>
-      <Formula id="Lumen_PKSim.PARAM_LiquidTransferRate_lje" name="PARAM_LiquidTransferRate_lje" dim="Flow" formula="w*Liquid*FillLevelFlagNext">
+      <Formula id="Lumen_PKSim.PARAM_InverseSITT_Factor_LowerJejunum" name="PARAM_InverseSITT_Factor_LowerJejunum" dim="Inversed time" formula="LuminalVelocity/SITT_fact">
         <Paths>
-          <Path path="267" as="268" dim="111" />
-          <Path path="247" as="248" dim="50" />
-          <Path path="396" as="270" />
+          <Path path="361" as="362" dim="50" />
+          <Path path="363" as="364" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.LiquidRHS_lje" name="LiquidRHS_lje" dim="Flow" formula="OralApplicationsEnabled ? LT_uje - LT_lje + Inflow*FillLevelFlag - Outflow*Liquid : 0">
         <Paths>
-          <Path path="341" as="342" dim="111" />
+          <Path path="369" as="370" dim="50" />
           <Path path="259" as="260" />
-          <Path path="247" as="248" dim="50" />
-          <Path path="261" as="397" dim="168" />
+          <Path path="247" as="248" dim="55" />
+          <Path path="261" as="409" dim="168" />
           <Path path="263" as="264" dim="168" />
-          <Path path="398" as="386" dim="168" />
+          <Path path="410" as="399" dim="168" />
           <Path path="265" as="266" />
         </Paths>
       </Formula>
-      <Formula id="Lumen_PKSim.PARAM_Outflow_LowerJejunum" name="PARAM_Outflow_LowerJejunum" dim="Inversed time" formula="(k_p*alpha_p*V_p+inflow-k*alpha*V)/(alpha*V)">
+      <Formula id="Lumen_PKSim.PARAM_LiquidTransferRate_lje" name="PARAM_LiquidTransferRate_lje" dim="Flow" formula="w*Liquid*FillLevelFlagNext">
         <Paths>
-          <Path path="257" as="359" dim="24" />
-          <Path path="267" as="360" dim="111" />
-          <Path path="263" as="361" dim="168" />
-          <Path path="134" as="138" dim="50" />
-          <Path path="399" as="363" dim="24" />
-          <Path path="400" as="365" dim="111" />
-          <Path path="401" as="367" dim="50" />
+          <Path path="267" as="268" dim="50" />
+          <Path path="247" as="248" dim="55" />
+          <Path path="411" as="270" />
         </Paths>
       </Formula>
-      <Formula id="Lumen_PKSim.PARAM_InverseSITT_Factor_LowerJejunum" name="PARAM_InverseSITT_Factor_LowerJejunum" dim="Inversed time" formula="LuminalVelocity/SITT_fact">
+      <Formula id="Lumen_PKSim.PARAM_Inflow_LowerJejunum" name="PARAM_Inflow_LowerJejunum" dim="Flow" formula="0.0025102*V">
+        <Paths>
+          <Path path="134" as="138" dim="55" />
+        </Paths>
+      </Formula>
+      <Formula id="MucosaVolume_Human.PARAM_VolumeGutWall_LowerJejunum" name="PARAM_VolumeGutWall_LowerJejunum" dim="Volume" formula="V_Intestine * 0.184">
         <Paths>
-          <Path path="332" as="333" dim="111" />
-          <Path path="334" as="335" />
+          <Path path="385" as="386" dim="55" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_lje" name="PARAM_OralMassAbsorbed_RHS_lje" dim="Amount per time" formula="PassiveRates_para+PassiveRates_trans-(ActiveRates_para+ActiveRates_trans)">
         <Paths>
-          <Path path="402" as="378" dim="379" />
-          <Path path="403" as="381" dim="379" />
-          <Path path="404" as="383" dim="379" />
-          <Path path="405" as="385" dim="379" />
+          <Path path="412" as="388" dim="389" />
+          <Path path="413" as="391" dim="389" />
+          <Path path="414" as="393" dim="389" />
+          <Path path="415" as="395" dim="389" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_Outflow_UpperIleum" name="PARAM_Outflow_UpperIleum" dim="Inversed time" formula="(k_p*alpha_p*V_p+inflow-k*alpha*V)/(alpha*V)">
         <Paths>
-          <Path path="257" as="359" dim="24" />
-          <Path path="267" as="360" dim="111" />
-          <Path path="263" as="361" dim="168" />
-          <Path path="134" as="138" dim="50" />
-          <Path path="406" as="363" dim="24" />
-          <Path path="407" as="365" dim="111" />
-          <Path path="408" as="367" dim="50" />
+          <Path path="257" as="342" dim="24" />
+          <Path path="267" as="343" dim="50" />
+          <Path path="263" as="344" dim="168" />
+          <Path path="134" as="138" dim="55" />
+          <Path path="416" as="346" dim="24" />
+          <Path path="417" as="348" dim="50" />
+          <Path path="418" as="350" dim="55" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_InverseSITT_Factor_UpperIleum" name="PARAM_InverseSITT_Factor_UpperIleum" dim="Inversed time" formula="LuminalVelocity/SITT_fact">
         <Paths>
-          <Path path="332" as="333" dim="111" />
-          <Path path="334" as="335" />
+          <Path path="361" as="362" dim="50" />
+          <Path path="363" as="364" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.LiquidRHS_uil" name="LiquidRHS_uil" dim="Flow" formula="OralApplicationsEnabled ? LT_lje - LT_uil + Inflow*FillLevelFlag - Outflow*Liquid : 0">
         <Paths>
-          <Path path="341" as="342" dim="111" />
+          <Path path="369" as="370" dim="50" />
           <Path path="259" as="260" />
-          <Path path="247" as="248" dim="50" />
-          <Path path="261" as="409" dim="168" />
+          <Path path="247" as="248" dim="55" />
+          <Path path="261" as="419" dim="168" />
           <Path path="263" as="264" dim="168" />
-          <Path path="410" as="397" dim="168" />
+          <Path path="420" as="409" dim="168" />
           <Path path="265" as="266" />
         </Paths>
       </Formula>
-      <Formula id="Lumen_PKSim.PARAM_Inflow_UpperIleum" name="PARAM_Inflow_UpperIleum" dim="Flow" formula="0.0029585*V">
+      <Formula id="Lumen_PKSim.PARAM_LiquidTransferRate_uil" name="PARAM_LiquidTransferRate_uil" dim="Flow" formula="w*Liquid*FillLevelFlagNext">
         <Paths>
-          <Path path="134" as="138" dim="50" />
+          <Path path="267" as="268" dim="50" />
+          <Path path="247" as="248" dim="55" />
+          <Path path="421" as="270" />
         </Paths>
       </Formula>
-      <Formula id="Lumen_PKSim.PARAM_LiquidTransferRate_uil" name="PARAM_LiquidTransferRate_uil" dim="Flow" formula="w*Liquid*FillLevelFlagNext">
+      <Formula id="Lumen_PKSim.PARAM_Inflow_UpperIleum" name="PARAM_Inflow_UpperIleum" dim="Flow" formula="0.0029585*V">
         <Paths>
-          <Path path="267" as="268" dim="111" />
-          <Path path="247" as="248" dim="50" />
-          <Path path="411" as="270" />
+          <Path path="134" as="138" dim="55" />
         </Paths>
       </Formula>
       <Formula id="MucosaVolume_Human.PARAM_VolumeGutWall_UpperIleum" name="PARAM_VolumeGutWall_UpperIleum" dim="Volume" formula="V_Intestine * 0.324">
         <Paths>
-          <Path path="357" as="358" dim="50" />
+          <Path path="385" as="386" dim="55" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_uil" name="PARAM_OralMassAbsorbed_RHS_uil" dim="Amount per time" formula="PassiveRates_para+PassiveRates_trans-(ActiveRates_para+ActiveRates_trans)">
         <Paths>
-          <Path path="412" as="378" dim="379" />
-          <Path path="413" as="381" dim="379" />
-          <Path path="414" as="383" dim="379" />
-          <Path path="415" as="385" dim="379" />
-        </Paths>
-      </Formula>
-      <Formula id="MucosaVolume_Human.PARAM_VolumeGutWall_LowerIleum" name="PARAM_VolumeGutWall_LowerIleum" dim="Volume" formula="V_Intestine * 0.156">
-        <Paths>
-          <Path path="357" as="358" dim="50" />
+          <Path path="422" as="388" dim="389" />
+          <Path path="423" as="391" dim="389" />
+          <Path path="424" as="393" dim="389" />
+          <Path path="425" as="395" dim="389" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_Outflow_LowerIleum" name="PARAM_Outflow_LowerIleum" dim="Inversed time" formula="(k_p*alpha_p*V_p+inflow-k*alpha*V)/(alpha*V)">
         <Paths>
-          <Path path="257" as="359" dim="24" />
-          <Path path="267" as="360" dim="111" />
-          <Path path="263" as="361" dim="168" />
-          <Path path="134" as="138" dim="50" />
-          <Path path="416" as="363" dim="24" />
-          <Path path="417" as="365" dim="111" />
-          <Path path="418" as="367" dim="50" />
+          <Path path="257" as="342" dim="24" />
+          <Path path="267" as="343" dim="50" />
+          <Path path="263" as="344" dim="168" />
+          <Path path="134" as="138" dim="55" />
+          <Path path="426" as="346" dim="24" />
+          <Path path="427" as="348" dim="50" />
+          <Path path="428" as="350" dim="55" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_InverseSITT_Factor_LowerIleum" name="PARAM_InverseSITT_Factor_LowerIleum" dim="Inversed time" formula="LuminalVelocity/SITT_fact">
         <Paths>
-          <Path path="332" as="333" dim="111" />
-          <Path path="334" as="335" />
+          <Path path="361" as="362" dim="50" />
+          <Path path="363" as="364" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.LiquidRHS_lil" name="LiquidRHS_lil" dim="Flow" formula="OralApplicationsEnabled ? LT_uil - LT_lil + Inflow*FillLevelFlag - Outflow*Liquid : 0">
         <Paths>
-          <Path path="341" as="342" dim="111" />
+          <Path path="369" as="370" dim="50" />
           <Path path="259" as="260" />
-          <Path path="247" as="248" dim="50" />
-          <Path path="261" as="419" dim="168" />
+          <Path path="247" as="248" dim="55" />
+          <Path path="261" as="429" dim="168" />
           <Path path="263" as="264" dim="168" />
-          <Path path="420" as="409" dim="168" />
+          <Path path="430" as="419" dim="168" />
           <Path path="265" as="266" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_LiquidTransferRate_lil" name="PARAM_LiquidTransferRate_lil" dim="Flow" formula="w*Liquid*FillLevelFlagNext">
         <Paths>
-          <Path path="267" as="268" dim="111" />
-          <Path path="247" as="248" dim="50" />
-          <Path path="421" as="270" />
+          <Path path="267" as="268" dim="50" />
+          <Path path="247" as="248" dim="55" />
+          <Path path="431" as="270" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_Inflow_LowerIleum" name="PARAM_Inflow_LowerIleum" dim="Flow" formula="0.0017657*V">
         <Paths>
-          <Path path="134" as="138" dim="50" />
+          <Path path="134" as="138" dim="55" />
         </Paths>
       </Formula>
-      <Formula id="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_lil" name="PARAM_OralMassAbsorbed_RHS_lil" dim="Amount per time" formula="PassiveRates_para+PassiveRates_trans-(ActiveRates_para+ActiveRates_trans)">
+      <Formula id="MucosaVolume_Human.PARAM_VolumeGutWall_LowerIleum" name="PARAM_VolumeGutWall_LowerIleum" dim="Volume" formula="V_Intestine * 0.156">
         <Paths>
-          <Path path="422" as="378" dim="379" />
-          <Path path="423" as="381" dim="379" />
-          <Path path="424" as="383" dim="379" />
-          <Path path="425" as="385" dim="379" />
+          <Path path="385" as="386" dim="55" />
         </Paths>
       </Formula>
-      <Formula id="MucosaVolume_Human.PARAM_VolumeGutWall_Caecum" name="PARAM_VolumeGutWall_Caecum" dim="Volume" formula="V_Intestine * 0.08470588">
+      <Formula id="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_lil" name="PARAM_OralMassAbsorbed_RHS_lil" dim="Amount per time" formula="PassiveRates_para+PassiveRates_trans-(ActiveRates_para+ActiveRates_trans)">
         <Paths>
-          <Path path="426" as="358" dim="50" />
+          <Path path="432" as="388" dim="389" />
+          <Path path="433" as="391" dim="389" />
+          <Path path="434" as="393" dim="389" />
+          <Path path="435" as="395" dim="389" />
         </Paths>
       </Formula>
-      <Formula id="Lumen_PKSim.PARAM_InverseLITT_Factor_Caecum" name="PARAM_InverseLITT_Factor_Caecum" dim="Inversed time" formula="LuminalVelocity/LITT_fact">
+      <Formula id="Lumen_PKSim.PARAM_Outflow_Caecum" name="PARAM_Outflow_Caecum" dim="Inversed time" formula="(k_p*alpha_p*V_p+inflow-k*alpha*V)/(alpha*V)">
         <Paths>
-          <Path path="332" as="333" dim="111" />
-          <Path path="427" as="428" />
+          <Path path="257" as="342" dim="24" />
+          <Path path="267" as="343" dim="50" />
+          <Path path="263" as="344" dim="168" />
+          <Path path="134" as="138" dim="55" />
+          <Path path="436" as="346" dim="24" />
+          <Path path="437" as="348" dim="50" />
+          <Path path="438" as="350" dim="55" />
         </Paths>
       </Formula>
-      <Formula id="Lumen_PKSim.PARAM_Outflow_Caecum" name="PARAM_Outflow_Caecum" dim="Inversed time" formula="(k_p*alpha_p*V_p+inflow-k*alpha*V)/(alpha*V)">
+      <Formula id="Lumen_PKSim.PARAM_InverseLITT_Factor_Caecum" name="PARAM_InverseLITT_Factor_Caecum" dim="Inversed time" formula="LuminalVelocity/LITT_fact">
         <Paths>
-          <Path path="257" as="359" dim="24" />
-          <Path path="267" as="360" dim="111" />
-          <Path path="263" as="361" dim="168" />
-          <Path path="134" as="138" dim="50" />
-          <Path path="429" as="363" dim="24" />
-          <Path path="430" as="365" dim="111" />
-          <Path path="431" as="367" dim="50" />
+          <Path path="361" as="362" dim="50" />
+          <Path path="439" as="440" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.LiquidRHS_cae" name="LiquidRHS_cae" dim="Flow" formula="OralApplicationsEnabled ? LT_lil - LT_cae + Inflow*FillLevelFlag - Outflow*Liquid : 0">
         <Paths>
-          <Path path="341" as="342" dim="111" />
+          <Path path="369" as="370" dim="50" />
           <Path path="259" as="260" />
-          <Path path="247" as="248" dim="50" />
-          <Path path="261" as="432" dim="168" />
+          <Path path="247" as="248" dim="55" />
+          <Path path="261" as="441" dim="168" />
           <Path path="263" as="264" dim="168" />
-          <Path path="433" as="419" dim="168" />
+          <Path path="442" as="429" dim="168" />
           <Path path="265" as="266" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_LiquidTransferRate_cae" name="PARAM_LiquidTransferRate_cae" dim="Flow" formula="w*Liquid*FillLevelFlagNext">
         <Paths>
-          <Path path="267" as="268" dim="111" />
-          <Path path="247" as="248" dim="50" />
-          <Path path="434" as="270" />
+          <Path path="267" as="268" dim="50" />
+          <Path path="247" as="248" dim="55" />
+          <Path path="443" as="270" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_Inflow_Caecum" name="PARAM_Inflow_Caecum" dim="Flow" formula="0*V">
         <Paths>
-          <Path path="134" as="138" dim="50" />
+          <Path path="134" as="138" dim="55" />
+        </Paths>
+      </Formula>
+      <Formula id="MucosaVolume_Human.PARAM_VolumeGutWall_Caecum" name="PARAM_VolumeGutWall_Caecum" dim="Volume" formula="V_Intestine * 0.08470588">
+        <Paths>
+          <Path path="444" as="386" dim="55" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_cae" name="PARAM_OralMassAbsorbed_RHS_cae" dim="Amount per time" formula="PassiveRates_para+PassiveRates_trans-(ActiveRates_para+ActiveRates_trans)">
         <Paths>
-          <Path path="435" as="378" dim="379" />
-          <Path path="436" as="381" dim="379" />
-          <Path path="437" as="383" dim="379" />
-          <Path path="438" as="385" dim="379" />
+          <Path path="445" as="388" dim="389" />
+          <Path path="446" as="391" dim="389" />
+          <Path path="447" as="393" dim="389" />
+          <Path path="448" as="395" dim="389" />
         </Paths>
       </Formula>
-      <Formula id="MucosaVolume_Human.PARAM_VolumeGutWall_ColonAscendens" name="PARAM_VolumeGutWall_ColonAscendens" dim="Volume" formula="V_Intestine * 0.15529412">
+      <Formula id="Lumen_PKSim.PARAM_Outflow_ColonAscendens" name="PARAM_Outflow_ColonAscendens" dim="Inversed time" formula="(k_p*alpha_p*V_p+inflow-k*alpha*V)/(alpha*V)">
+        <Paths>
+          <Path path="257" as="342" dim="24" />
+          <Path path="267" as="343" dim="50" />
+          <Path path="263" as="344" dim="168" />
+          <Path path="134" as="138" dim="55" />
+          <Path path="449" as="346" dim="24" />
+          <Path path="450" as="348" dim="50" />
+          <Path path="451" as="350" dim="55" />
+        </Paths>
+      </Formula>
+      <Formula id="Lumen_PKSim.PARAM_InverseLITT_Factor_ColonAscendens" name="PARAM_InverseLITT_Factor_ColonAscendens" dim="Inversed time" formula="LuminalVelocity/LITT_fact">
         <Paths>
-          <Path path="426" as="358" dim="50" />
+          <Path path="361" as="362" dim="50" />
+          <Path path="439" as="440" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.LiquidRHS_colasc" name="LiquidRHS_colasc" dim="Flow" formula="OralApplicationsEnabled ? LT_cae - LT_colasc + Inflow*FillLevelFlag - Outflow*Liquid : 0">
         <Paths>
-          <Path path="341" as="342" dim="111" />
+          <Path path="369" as="370" dim="50" />
           <Path path="259" as="260" />
-          <Path path="247" as="248" dim="50" />
-          <Path path="261" as="439" dim="168" />
+          <Path path="247" as="248" dim="55" />
+          <Path path="261" as="452" dim="168" />
           <Path path="263" as="264" dim="168" />
-          <Path path="440" as="432" dim="168" />
+          <Path path="453" as="441" dim="168" />
           <Path path="265" as="266" />
         </Paths>
       </Formula>
-      <Formula id="Lumen_PKSim.PARAM_Outflow_ColonAscendens" name="PARAM_Outflow_ColonAscendens" dim="Inversed time" formula="(k_p*alpha_p*V_p+inflow-k*alpha*V)/(alpha*V)">
-        <Paths>
-          <Path path="257" as="359" dim="24" />
-          <Path path="267" as="360" dim="111" />
-          <Path path="263" as="361" dim="168" />
-          <Path path="134" as="138" dim="50" />
-          <Path path="441" as="363" dim="24" />
-          <Path path="442" as="365" dim="111" />
-          <Path path="443" as="367" dim="50" />
-        </Paths>
-      </Formula>
       <Formula id="Lumen_PKSim.PARAM_LiquidTransferRate_colasc" name="PARAM_LiquidTransferRate_colasc" dim="Flow" formula="w*Liquid*FillLevelFlagNext">
         <Paths>
-          <Path path="267" as="268" dim="111" />
-          <Path path="247" as="248" dim="50" />
-          <Path path="444" as="270" />
+          <Path path="267" as="268" dim="50" />
+          <Path path="247" as="248" dim="55" />
+          <Path path="454" as="270" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_Inflow_ColonAscendens" name="PARAM_Inflow_ColonAscendens" dim="Flow" formula="0.00098426*V">
         <Paths>
-          <Path path="134" as="138" dim="50" />
+          <Path path="134" as="138" dim="55" />
         </Paths>
       </Formula>
-      <Formula id="Lumen_PKSim.PARAM_InverseLITT_Factor_ColonAscendens" name="PARAM_InverseLITT_Factor_ColonAscendens" dim="Inversed time" formula="LuminalVelocity/LITT_fact">
+      <Formula id="MucosaVolume_Human.PARAM_VolumeGutWall_ColonAscendens" name="PARAM_VolumeGutWall_ColonAscendens" dim="Volume" formula="V_Intestine * 0.15529412">
         <Paths>
-          <Path path="332" as="333" dim="111" />
-          <Path path="427" as="428" />
+          <Path path="444" as="386" dim="55" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_colasc" name="PARAM_OralMassAbsorbed_RHS_colasc" dim="Amount per time" formula="PassiveRates_para+PassiveRates_trans-(ActiveRates_para+ActiveRates_trans)">
         <Paths>
-          <Path path="445" as="378" dim="379" />
-          <Path path="446" as="381" dim="379" />
-          <Path path="447" as="383" dim="379" />
-          <Path path="448" as="385" dim="379" />
+          <Path path="455" as="388" dim="389" />
+          <Path path="456" as="391" dim="389" />
+          <Path path="457" as="393" dim="389" />
+          <Path path="458" as="395" dim="389" />
         </Paths>
       </Formula>
-      <Formula id="Lumen_PKSim.PARAM_InverseLITT_Factor_ColonTransversum" name="PARAM_InverseLITT_Factor_ColonTransversum" dim="Inversed time" formula="LuminalVelocity/LITT_fact">
+      <Formula id="Lumen_PKSim.PARAM_Outflow_ColonTransversum" name="PARAM_Outflow_ColonTransversum" dim="Inversed time" formula="(k_p*alpha_p*V_p+inflow-k*alpha*V)/(alpha*V)">
         <Paths>
-          <Path path="332" as="333" dim="111" />
-          <Path path="427" as="428" />
+          <Path path="257" as="342" dim="24" />
+          <Path path="267" as="343" dim="50" />
+          <Path path="263" as="344" dim="168" />
+          <Path path="134" as="138" dim="55" />
+          <Path path="459" as="346" dim="24" />
+          <Path path="460" as="348" dim="50" />
+          <Path path="461" as="350" dim="55" />
         </Paths>
       </Formula>
-      <Formula id="Lumen_PKSim.PARAM_LiquidTransferRate_coltrans" name="PARAM_LiquidTransferRate_coltrans" dim="Flow" formula="w*Liquid*FillLevelFlagNext">
+      <Formula id="Lumen_PKSim.PARAM_InverseLITT_Factor_ColonTransversum" name="PARAM_InverseLITT_Factor_ColonTransversum" dim="Inversed time" formula="LuminalVelocity/LITT_fact">
         <Paths>
-          <Path path="267" as="268" dim="111" />
-          <Path path="247" as="248" dim="50" />
-          <Path path="449" as="270" />
+          <Path path="361" as="362" dim="50" />
+          <Path path="439" as="440" />
         </Paths>
       </Formula>
-      <Formula id="Lumen_PKSim.PARAM_Inflow_ColonTransversum" name="PARAM_Inflow_ColonTransversum" dim="Flow" formula="0.00020285*V">
+      <Formula id="Lumen_PKSim.LiquidRHS_coltrans" name="LiquidRHS_coltrans" dim="Flow" formula="OralApplicationsEnabled ? LT_colasc - LT_coltrans + Inflow*FillLevelFlag - Outflow*Liquid : 0">
         <Paths>
-          <Path path="134" as="138" dim="50" />
+          <Path path="369" as="370" dim="50" />
+          <Path path="259" as="260" />
+          <Path path="247" as="248" dim="55" />
+          <Path path="261" as="462" dim="168" />
+          <Path path="263" as="264" dim="168" />
+          <Path path="463" as="452" dim="168" />
+          <Path path="265" as="266" />
         </Paths>
       </Formula>
-      <Formula id="MucosaVolume_Human.PARAM_VolumeGutWall_ColonTransversum" name="PARAM_VolumeGutWall_ColonTransversum" dim="Volume" formula="V_Intestine * 0.32">
+      <Formula id="Lumen_PKSim.PARAM_LiquidTransferRate_coltrans" name="PARAM_LiquidTransferRate_coltrans" dim="Flow" formula="w*Liquid*FillLevelFlagNext">
         <Paths>
-          <Path path="426" as="358" dim="50" />
+          <Path path="267" as="268" dim="50" />
+          <Path path="247" as="248" dim="55" />
+          <Path path="464" as="270" />
         </Paths>
       </Formula>
-      <Formula id="Lumen_PKSim.LiquidRHS_coltrans" name="LiquidRHS_coltrans" dim="Flow" formula="OralApplicationsEnabled ? LT_colasc - LT_coltrans + Inflow*FillLevelFlag - Outflow*Liquid : 0">
+      <Formula id="Lumen_PKSim.PARAM_Inflow_ColonTransversum" name="PARAM_Inflow_ColonTransversum" dim="Flow" formula="0.00020285*V">
         <Paths>
-          <Path path="341" as="342" dim="111" />
-          <Path path="259" as="260" />
-          <Path path="247" as="248" dim="50" />
-          <Path path="261" as="450" dim="168" />
-          <Path path="263" as="264" dim="168" />
-          <Path path="451" as="439" dim="168" />
-          <Path path="265" as="266" />
+          <Path path="134" as="138" dim="55" />
         </Paths>
       </Formula>
-      <Formula id="Lumen_PKSim.PARAM_Outflow_ColonTransversum" name="PARAM_Outflow_ColonTransversum" dim="Inversed time" formula="(k_p*alpha_p*V_p+inflow-k*alpha*V)/(alpha*V)">
+      <Formula id="MucosaVolume_Human.PARAM_VolumeGutWall_ColonTransversum" name="PARAM_VolumeGutWall_ColonTransversum" dim="Volume" formula="V_Intestine * 0.32">
         <Paths>
-          <Path path="257" as="359" dim="24" />
-          <Path path="267" as="360" dim="111" />
-          <Path path="263" as="361" dim="168" />
-          <Path path="134" as="138" dim="50" />
-          <Path path="452" as="363" dim="24" />
-          <Path path="453" as="365" dim="111" />
-          <Path path="454" as="367" dim="50" />
+          <Path path="444" as="386" dim="55" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_coltrans" name="PARAM_OralMassAbsorbed_RHS_coltrans" dim="Amount per time" formula="PassiveRates_para+PassiveRates_trans-(ActiveRates_para+ActiveRates_trans)">
         <Paths>
-          <Path path="455" as="378" dim="379" />
-          <Path path="456" as="381" dim="379" />
-          <Path path="457" as="383" dim="379" />
-          <Path path="458" as="385" dim="379" />
+          <Path path="465" as="388" dim="389" />
+          <Path path="466" as="391" dim="389" />
+          <Path path="467" as="393" dim="389" />
+          <Path path="468" as="395" dim="389" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_Outflow_ColonDescendens" name="PARAM_Outflow_ColonDescendens" dim="Inversed time" formula="(k_p*alpha_p*V_p+inflow-k*alpha*V)/(alpha*V)">
         <Paths>
-          <Path path="257" as="359" dim="24" />
-          <Path path="267" as="360" dim="111" />
-          <Path path="263" as="361" dim="168" />
-          <Path path="134" as="138" dim="50" />
-          <Path path="459" as="363" dim="24" />
-          <Path path="460" as="365" dim="111" />
-          <Path path="461" as="367" dim="50" />
+          <Path path="257" as="342" dim="24" />
+          <Path path="267" as="343" dim="50" />
+          <Path path="263" as="344" dim="168" />
+          <Path path="134" as="138" dim="55" />
+          <Path path="469" as="346" dim="24" />
+          <Path path="470" as="348" dim="50" />
+          <Path path="471" as="350" dim="55" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_InverseLITT_Factor_ColonDescendens" name="PARAM_InverseLITT_Factor_ColonDescendens" dim="Inversed time" formula="LuminalVelocity/LITT_fact">
         <Paths>
-          <Path path="332" as="333" dim="111" />
-          <Path path="427" as="428" />
+          <Path path="361" as="362" dim="50" />
+          <Path path="439" as="440" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.LiquidRHS_coldesc" name="LiquidRHS_coldesc" dim="Flow" formula="OralApplicationsEnabled ? LT_coltrans - LT_coldesc + Inflow*FillLevelFlag - Outflow*Liquid : 0">
         <Paths>
-          <Path path="341" as="342" dim="111" />
+          <Path path="369" as="370" dim="50" />
           <Path path="259" as="260" />
-          <Path path="247" as="248" dim="50" />
-          <Path path="261" as="462" dim="168" />
+          <Path path="247" as="248" dim="55" />
+          <Path path="261" as="472" dim="168" />
           <Path path="263" as="264" dim="168" />
-          <Path path="463" as="450" dim="168" />
+          <Path path="473" as="462" dim="168" />
           <Path path="265" as="266" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_LiquidTransferRate_coldesc" name="PARAM_LiquidTransferRate_coldesc" dim="Flow" formula="w*Liquid*FillLevelFlagNext">
         <Paths>
-          <Path path="267" as="268" dim="111" />
-          <Path path="247" as="248" dim="50" />
-          <Path path="464" as="270" />
+          <Path path="267" as="268" dim="50" />
+          <Path path="247" as="248" dim="55" />
+          <Path path="474" as="270" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_Inflow_ColonDescendens" name="PARAM_Inflow_ColonDescendens" dim="Flow" formula="0.00023004*V">
         <Paths>
-          <Path path="134" as="138" dim="50" />
+          <Path path="134" as="138" dim="55" />
         </Paths>
       </Formula>
       <Formula id="MucosaVolume_Human.PARAM_VolumeGutWall_ColonDescendens" name="PARAM_VolumeGutWall_ColonDescendens" dim="Volume" formula="V_Intestine * 0.24">
         <Paths>
-          <Path path="426" as="358" dim="50" />
+          <Path path="444" as="386" dim="55" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_coldesc" name="PARAM_OralMassAbsorbed_RHS_coldesc" dim="Amount per time" formula="PassiveRates_para+PassiveRates_trans-(ActiveRates_para+ActiveRates_trans)">
         <Paths>
-          <Path path="465" as="378" dim="379" />
-          <Path path="466" as="381" dim="379" />
-          <Path path="467" as="383" dim="379" />
-          <Path path="468" as="385" dim="379" />
+          <Path path="475" as="388" dim="389" />
+          <Path path="476" as="391" dim="389" />
+          <Path path="477" as="393" dim="389" />
+          <Path path="478" as="395" dim="389" />
+        </Paths>
+      </Formula>
+      <Formula id="Lumen_PKSim.PARAM_Outflow_ColonSigmoid" name="PARAM_Outflow_ColonSigmoid" dim="Inversed time" formula="(k_p*alpha_p*V_p+inflow-k*alpha*V)/(alpha*V)">
+        <Paths>
+          <Path path="257" as="342" dim="24" />
+          <Path path="267" as="343" dim="50" />
+          <Path path="263" as="344" dim="168" />
+          <Path path="134" as="138" dim="55" />
+          <Path path="479" as="346" dim="24" />
+          <Path path="480" as="348" dim="50" />
+          <Path path="481" as="350" dim="55" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_InverseLITT_Factor_ColonSigmoid" name="PARAM_InverseLITT_Factor_ColonSigmoid" dim="Inversed time" formula="LuminalVelocity/LITT_fact">
         <Paths>
-          <Path path="332" as="333" dim="111" />
-          <Path path="427" as="428" />
+          <Path path="361" as="362" dim="50" />
+          <Path path="439" as="440" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.LiquidRHS_colsigm" name="LiquidRHS_colsigm" dim="Flow" formula="OralApplicationsEnabled ? LT_coldesc - LT_colsigm + Inflow*FillLevelFlag - Outflow*Liquid : 0">
         <Paths>
-          <Path path="341" as="342" dim="111" />
+          <Path path="369" as="370" dim="50" />
           <Path path="259" as="260" />
-          <Path path="247" as="248" dim="50" />
-          <Path path="261" as="469" dim="168" />
+          <Path path="247" as="248" dim="55" />
+          <Path path="261" as="482" dim="168" />
           <Path path="263" as="264" dim="168" />
-          <Path path="470" as="462" dim="168" />
+          <Path path="483" as="472" dim="168" />
           <Path path="265" as="266" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_LiquidTransferRate_colsigm" name="PARAM_LiquidTransferRate_colsigm" dim="Flow" formula="w*Liquid*FillLevelFlagNext">
         <Paths>
-          <Path path="267" as="268" dim="111" />
-          <Path path="247" as="248" dim="50" />
-          <Path path="471" as="270" />
+          <Path path="267" as="268" dim="50" />
+          <Path path="247" as="248" dim="55" />
+          <Path path="484" as="270" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_Inflow_ColonSigmoid" name="PARAM_Inflow_ColonSigmoid" dim="Flow" formula="0.00013099*V">
         <Paths>
-          <Path path="134" as="138" dim="50" />
+          <Path path="134" as="138" dim="55" />
         </Paths>
       </Formula>
       <Formula id="MucosaVolume_Human.PARAM_VolumeGutWall_ColonSigmoid" name="PARAM_VolumeGutWall_ColonSigmoid" dim="Volume" formula="V_Intestine * 0.135">
         <Paths>
-          <Path path="426" as="358" dim="50" />
-        </Paths>
-      </Formula>
-      <Formula id="Lumen_PKSim.PARAM_Outflow_ColonSigmoid" name="PARAM_Outflow_ColonSigmoid" dim="Inversed time" formula="(k_p*alpha_p*V_p+inflow-k*alpha*V)/(alpha*V)">
-        <Paths>
-          <Path path="257" as="359" dim="24" />
-          <Path path="267" as="360" dim="111" />
-          <Path path="263" as="361" dim="168" />
-          <Path path="134" as="138" dim="50" />
-          <Path path="472" as="363" dim="24" />
-          <Path path="473" as="365" dim="111" />
-          <Path path="474" as="367" dim="50" />
+          <Path path="444" as="386" dim="55" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_colsigm" name="PARAM_OralMassAbsorbed_RHS_colsigm" dim="Amount per time" formula="PassiveRates_para+PassiveRates_trans-(ActiveRates_para+ActiveRates_trans)">
         <Paths>
-          <Path path="475" as="378" dim="379" />
-          <Path path="476" as="381" dim="379" />
-          <Path path="477" as="383" dim="379" />
-          <Path path="478" as="385" dim="379" />
+          <Path path="485" as="388" dim="389" />
+          <Path path="486" as="391" dim="389" />
+          <Path path="487" as="393" dim="389" />
+          <Path path="488" as="395" dim="389" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_Outflow_Rectum" name="PARAM_Outflow_Rectum" dim="Inversed time" formula="(k_p*alpha_p*V_p+inflow-k*alpha*V)/(alpha*V)">
         <Paths>
-          <Path path="257" as="359" dim="24" />
-          <Path path="267" as="360" dim="111" />
-          <Path path="263" as="361" dim="168" />
-          <Path path="134" as="138" dim="50" />
-          <Path path="479" as="363" dim="24" />
-          <Path path="480" as="365" dim="111" />
-          <Path path="481" as="367" dim="50" />
+          <Path path="257" as="342" dim="24" />
+          <Path path="267" as="343" dim="50" />
+          <Path path="263" as="344" dim="168" />
+          <Path path="134" as="138" dim="55" />
+          <Path path="489" as="346" dim="24" />
+          <Path path="490" as="348" dim="50" />
+          <Path path="491" as="350" dim="55" />
         </Paths>
       </Formula>
-      <Formula id="MucosaVolume_Human.PARAM_VolumeGutWall_Rectum" name="PARAM_VolumeGutWall_Rectum" dim="Volume" formula="V_Intestine * 0.055">
+      <Formula id="Lumen_PKSim.PARAM_InverseLITT_Factor_Rectum" name="PARAM_InverseLITT_Factor_Rectum" dim="Inversed time" formula="LuminalVelocity/LITT_fact">
         <Paths>
-          <Path path="426" as="358" dim="50" />
+          <Path path="361" as="362" dim="50" />
+          <Path path="439" as="440" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.LiquidRHS_rect" name="LiquidRHS_rect" dim="Flow" formula="OralApplicationsEnabled ? LT_colsigm - LT_rect + Inflow*FillLevelFlag : 0">
         <Paths>
           <Path path="259" as="260" />
-          <Path path="261" as="482" dim="168" />
+          <Path path="261" as="492" dim="168" />
           <Path path="263" as="264" dim="168" />
-          <Path path="483" as="469" dim="168" />
+          <Path path="493" as="482" dim="168" />
           <Path path="265" as="266" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_LiquidTransferRate_rect" name="PARAM_LiquidTransferRate_rect" dim="Flow" formula="w*Liquid">
         <Paths>
-          <Path path="267" as="268" dim="111" />
-          <Path path="247" as="248" dim="50" />
+          <Path path="267" as="268" dim="50" />
+          <Path path="247" as="248" dim="55" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_Inflow_Rectum" name="PARAM_Inflow_Rectum" dim="Flow" formula="0.00071247*V">
         <Paths>
-          <Path path="134" as="138" dim="50" />
+          <Path path="134" as="138" dim="55" />
         </Paths>
       </Formula>
-      <Formula id="Lumen_PKSim.PARAM_InverseLITT_Factor_Rectum" name="PARAM_InverseLITT_Factor_Rectum" dim="Inversed time" formula="LuminalVelocity/LITT_fact">
+      <Formula id="MucosaVolume_Human.PARAM_VolumeGutWall_Rectum" name="PARAM_VolumeGutWall_Rectum" dim="Volume" formula="V_Intestine * 0.055">
         <Paths>
-          <Path path="332" as="333" dim="111" />
-          <Path path="427" as="428" />
+          <Path path="444" as="386" dim="55" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_rect" name="PARAM_OralMassAbsorbed_RHS_rect" dim="Amount per time" formula="PassiveRates_para+PassiveRates_trans-(ActiveRates_para+ActiveRates_trans)">
         <Paths>
-          <Path path="484" as="378" dim="379" />
-          <Path path="485" as="381" dim="379" />
-          <Path path="486" as="383" dim="379" />
-          <Path path="487" as="385" dim="379" />
+          <Path path="494" as="388" dim="389" />
+          <Path path="495" as="391" dim="389" />
+          <Path path="496" as="393" dim="389" />
+          <Path path="497" as="395" dim="389" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.LiquidRHS_fec" name="LiquidRHS_fec" dim="Flow" formula="OralApplicationsEnabled ? LT_rec : 0">
         <Paths>
-          <Path path="488" as="489" dim="168" />
+          <Path path="498" as="499" dim="168" />
           <Path path="265" as="266" />
         </Paths>
       </Formula>
       <Formula id="VascularEndoVolume.VOLUME_VascularEndo_sto" name="VOLUME_VascularEndo_sto" dim="Volume" formula="SA_pls_int*d_endo">
         <Paths>
           <Path path="177" as="178" dim="127" />
-          <Path path="490" as="180" dim="181" />
+          <Path path="500" as="180" dim="181" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_sto" name="PARAM_K_Water_INT_sto" formula="K_water_int">
         <Paths>
-          <Path path="491" as="193" />
+          <Path path="501" as="193" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_sto" name="PARAM_K_Water_CELL_sto" formula="K_water_cell">
         <Paths>
-          <Path path="492" as="197" />
+          <Path path="502" as="197" />
         </Paths>
       </Formula>
       <Formula id="CompartmentsVolume_2Poren.VOLUME_end_sto" name="VOLUME_end_sto" dim="Volume" formula="f_endo*SA_pls_int*d_endo">
         <Paths>
           <Path path="199" as="200" dim="24" />
           <Path path="177" as="178" dim="127" />
-          <Path path="490" as="180" dim="181" />
+          <Path path="500" as="180" dim="181" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_SITT_Factor" name="PARAM_SITT_Factor" formula="P1*SITT+P2">
         <Paths>
-          <Path path="493" as="494" dim="146" />
-          <Path path="495" as="496" />
-          <Path path="497" as="498" dim="111" />
+          <Path path="503" as="504" dim="146" />
+          <Path path="505" as="506" />
+          <Path path="507" as="508" dim="50" />
         </Paths>
       </Formula>
       <Formula id="Individual_PKSim.PARAM_FluidRecirculationRate_sin" name="PARAM_FluidRecirculationRate_sin" dim="Flow" formula="J_iso_incl_Mucosa-J_iso_duo-J_iso_uje-J_iso_lje-J_iso_uil-J_iso_lil">
         <Paths>
-          <Path path="499" as="500" dim="168" />
-          <Path path="501" as="502" dim="168" />
-          <Path path="503" as="504" dim="168" />
-          <Path path="505" as="506" dim="168" />
-          <Path path="507" as="508" dim="168" />
           <Path path="509" as="510" dim="168" />
+          <Path path="511" as="512" dim="168" />
+          <Path path="513" as="514" dim="168" />
+          <Path path="515" as="516" dim="168" />
+          <Path path="517" as="518" dim="168" />
+          <Path path="519" as="520" dim="168" />
         </Paths>
       </Formula>
-      <Formula id="VascularEndoVolume.VOLUME_VascularEndo_sin" name="VOLUME_VascularEndo_sin" dim="Volume" formula="SA_pls_int*d_endo">
+      <Formula id="Individual_PKSim.PARAM_Q_Lymph_sin" name="PARAM_Q_Lymph_sin" dim="Flow" formula="Q_lymph_incl_Mucosa-Q_lymph_duo-Q_lymph_uje-Q_lymph_lje-Q_lymph_uil-Q_lymph_lil">
         <Paths>
-          <Path path="177" as="178" dim="127" />
-          <Path path="511" as="180" dim="181" />
+          <Path path="521" as="522" dim="168" />
+          <Path path="523" as="524" dim="168" />
+          <Path path="525" as="526" dim="168" />
+          <Path path="527" as="528" dim="168" />
+          <Path path="529" as="530" dim="168" />
+          <Path path="531" as="532" dim="168" />
         </Paths>
       </Formula>
-      <Formula id="Individual_PKSim.PARAM_Q_Lymph_sin" name="PARAM_Q_Lymph_sin" dim="Flow" formula="Q_lymph_incl_Mucosa-Q_lymph_duo-Q_lymph_uje-Q_lymph_lje-Q_lymph_uil-Q_lymph_lil">
+      <Formula id="VascularEndoVolume.VOLUME_VascularEndo_sin" name="VOLUME_VascularEndo_sin" dim="Volume" formula="SA_pls_int*d_endo">
         <Paths>
-          <Path path="512" as="513" dim="168" />
-          <Path path="514" as="515" dim="168" />
-          <Path path="516" as="517" dim="168" />
-          <Path path="518" as="519" dim="168" />
-          <Path path="520" as="521" dim="168" />
-          <Path path="522" as="523" dim="168" />
+          <Path path="177" as="178" dim="127" />
+          <Path path="533" as="180" dim="181" />
         </Paths>
       </Formula>
       <Formula id="MucosaVolume.VOLUME_SmallIntestineMucosa" name="VOLUME_SmallIntestineMucosa" dim="Volume" formula="V_duo+V_uje+V_lje+V_uil+V_lil">
         <Paths>
-          <Path path="524" as="525" dim="50" />
-          <Path path="526" as="527" dim="50" />
-          <Path path="528" as="529" dim="50" />
-          <Path path="530" as="531" dim="50" />
-          <Path path="532" as="533" dim="50" />
+          <Path path="534" as="535" dim="55" />
+          <Path path="536" as="537" dim="55" />
+          <Path path="538" as="539" dim="55" />
+          <Path path="540" as="541" dim="55" />
+          <Path path="542" as="543" dim="55" />
         </Paths>
       </Formula>
       <Formula id="CompartmentsVolume_2Poren.VOLUME_pls_SinLin" name="VOLUME_pls_SinLin" dim="Volume" formula="f_vas*(1-HCT)*(V-V_Mucosa)">
         <Paths>
           <Path path="135" as="136" />
-          <Path path="137" as="138" dim="50" />
-          <Path path="534" as="535" dim="50" />
+          <Path path="137" as="138" dim="55" />
+          <Path path="544" as="545" dim="55" />
           <Path path="40" as="41" />
         </Paths>
       </Formula>
       <Formula id="CompartmentsVolume_2Poren.VOLUME_bc_SinLin" name="VOLUME_bc_SinLin" dim="Volume" formula="f_vas*HCT*(V-V_Mucosa)">
         <Paths>
           <Path path="135" as="136" />
-          <Path path="137" as="138" dim="50" />
-          <Path path="534" as="535" dim="50" />
+          <Path path="137" as="138" dim="55" />
+          <Path path="544" as="545" dim="55" />
           <Path path="40" as="41" />
         </Paths>
       </Formula>
       <Formula id="CompartmentsVolume_2Poren.VOLUME_int_SinLin" name="VOLUME_int_SinLin" dim="Volume" formula="f_int*(V-V_Mucosa)">
         <Paths>
           <Path path="189" as="183" />
-          <Path path="137" as="138" dim="50" />
-          <Path path="534" as="535" dim="50" />
+          <Path path="137" as="138" dim="55" />
+          <Path path="544" as="545" dim="55" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_sin" name="PARAM_K_Water_INT_sin" formula="K_water_int">
         <Paths>
-          <Path path="536" as="193" />
+          <Path path="546" as="193" />
         </Paths>
       </Formula>
       <Formula id="CompoundCommon.PARAM_ProteinContainerVolume_Organ_SinLin" name="PARAM_ProteinContainerVolume_Organ_SinLin" dim="Volume" formula="Volume-V_Mucosa">
         <Paths>
-          <Path path="137" as="50" dim="50" />
-          <Path path="534" as="535" dim="50" />
+          <Path path="137" as="55" dim="55" />
+          <Path path="544" as="545" dim="55" />
         </Paths>
       </Formula>
       <Formula id="CompartmentsVolume_2Poren.VOLUME_cell_SinLin" name="VOLUME_cell_SinLin" dim="Volume" formula="f_cell*(V-V_Mucosa)">
         <Paths>
           <Path path="194" as="195" />
-          <Path path="137" as="138" dim="50" />
-          <Path path="534" as="535" dim="50" />
+          <Path path="137" as="138" dim="55" />
+          <Path path="544" as="545" dim="55" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_sin" name="PARAM_K_Water_CELL_sin" formula="K_water_cell">
         <Paths>
-          <Path path="537" as="197" />
+          <Path path="547" as="197" />
         </Paths>
       </Formula>
       <Formula id="CompartmentsVolume_2Poren.VOLUME_end_sin" name="VOLUME_end_sin" dim="Volume" formula="f_endo*SA_pls_int*d_endo">
         <Paths>
           <Path path="199" as="200" dim="24" />
           <Path path="177" as="178" dim="127" />
-          <Path path="511" as="180" dim="181" />
+          <Path path="533" as="180" dim="181" />
         </Paths>
       </Formula>
       <Formula id="MucosaVolume.VOLUME_MucosaDuodenum" name="VOLUME_MucosaDuodenum" dim="Volume" formula="V_GutWall*fractionMucosa">
         <Paths>
-          <Path path="538" as="539" />
-          <Path path="540" as="541" dim="50" />
+          <Path path="548" as="549" />
+          <Path path="550" as="551" dim="55" />
         </Paths>
       </Formula>
-      <Formula id="Individual_PKSim.PARAM_Q_lymph_mucosa" name="PARAM_Q_lymph_mucosa" dim="Flow" formula="Q_lymph_intestine * V_seg / V_intestine">
+      <Formula id="Individual_PKSim.PARAM_J_iso_Mucosa" name="PARAM_J_iso_Mucosa" dim="Flow" formula="J_iso_intestine * V_seg / V_intestine">
         <Paths>
-          <Path path="542" as="543" dim="168" />
-          <Path path="544" as="545" dim="50" />
-          <Path path="134" as="546" dim="50" />
+          <Path path="552" as="553" dim="168" />
+          <Path path="554" as="555" dim="55" />
+          <Path path="134" as="556" dim="55" />
         </Paths>
       </Formula>
-      <Formula id="VascularEndoVolume.VOLUME_VascularEndo_duo" name="VOLUME_VascularEndo_duo" dim="Volume" formula="SA_pls_int*d_endo">
+      <Formula id="Individual_PKSim.PARAM_Q_lymph_mucosa" name="PARAM_Q_lymph_mucosa" dim="Flow" formula="Q_lymph_intestine * V_seg / V_intestine">
         <Paths>
-          <Path path="177" as="178" dim="127" />
-          <Path path="547" as="180" dim="181" />
+          <Path path="557" as="558" dim="168" />
+          <Path path="554" as="555" dim="55" />
+          <Path path="134" as="556" dim="55" />
         </Paths>
       </Formula>
-      <Formula id="Individual_PKSim.PARAM_J_iso_Mucosa" name="PARAM_J_iso_Mucosa" dim="Flow" formula="J_iso_intestine * V_seg / V_intestine">
+      <Formula id="VascularEndoVolume.VOLUME_VascularEndo_duo" name="VOLUME_VascularEndo_duo" dim="Volume" formula="SA_pls_int*d_endo">
         <Paths>
-          <Path path="548" as="549" dim="168" />
-          <Path path="544" as="545" dim="50" />
-          <Path path="134" as="546" dim="50" />
+          <Path path="177" as="178" dim="127" />
+          <Path path="559" as="180" dim="181" />
         </Paths>
       </Formula>
       <Formula id="Individual_PKSim.PARAM_Q_mucosa" name="PARAM_Q_mucosa" dim="Flow" formula="Q * fractQ * regionalFractQ">
         <Paths>
-          <Path path="550" as="174" dim="168" />
-          <Path path="551" as="552" />
-          <Path path="553" as="554" />
+          <Path path="560" as="174" dim="168" />
+          <Path path="561" as="562" />
+          <Path path="563" as="564" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_duo" name="PARAM_K_Water_INT_duo" formula="K_water_int">
         <Paths>
-          <Path path="555" as="193" />
+          <Path path="565" as="193" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_duo" name="PARAM_K_Water_CELL_duo" formula="K_water_cell">
         <Paths>
-          <Path path="556" as="197" />
+          <Path path="566" as="197" />
         </Paths>
       </Formula>
       <Formula id="CompartmentsVolume_2Poren.VOLUME_end_duo" name="VOLUME_end_duo" dim="Volume" formula="f_endo*SA_pls_int*d_endo">
         <Paths>
           <Path path="199" as="200" dim="24" />
           <Path path="177" as="178" dim="127" />
-          <Path path="547" as="180" dim="181" />
+          <Path path="559" as="180" dim="181" />
         </Paths>
       </Formula>
       <Formula id="MucosaVolume.VOLUME_MucosaUpperJejunum" name="VOLUME_MucosaUpperJejunum" dim="Volume" formula="V_GutWall*fractionMucosa">
         <Paths>
-          <Path path="538" as="539" />
-          <Path path="557" as="541" dim="50" />
+          <Path path="548" as="549" />
+          <Path path="567" as="551" dim="55" />
         </Paths>
       </Formula>
       <Formula id="VascularEndoVolume.VOLUME_VascularEndo_uje" name="VOLUME_VascularEndo_uje" dim="Volume" formula="SA_pls_int*d_endo">
         <Paths>
           <Path path="177" as="178" dim="127" />
-          <Path path="558" as="180" dim="181" />
+          <Path path="568" as="180" dim="181" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_uje" name="PARAM_K_Water_INT_uje" formula="K_water_int">
         <Paths>
-          <Path path="559" as="193" />
+          <Path path="569" as="193" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_uje" name="PARAM_K_Water_CELL_uje" formula="K_water_cell">
         <Paths>
-          <Path path="560" as="197" />
+          <Path path="570" as="197" />
         </Paths>
       </Formula>
       <Formula id="CompartmentsVolume_2Poren.VOLUME_end_uje" name="VOLUME_end_uje" dim="Volume" formula="f_endo*SA_pls_int*d_endo">
         <Paths>
           <Path path="199" as="200" dim="24" />
           <Path path="177" as="178" dim="127" />
-          <Path path="558" as="180" dim="181" />
+          <Path path="568" as="180" dim="181" />
         </Paths>
       </Formula>
       <Formula id="MucosaVolume.VOLUME_MucosaLowerJejunum" name="VOLUME_MucosaLowerJejunum" dim="Volume" formula="V_GutWall*fractionMucosa">
         <Paths>
-          <Path path="538" as="539" />
-          <Path path="561" as="541" dim="50" />
+          <Path path="548" as="549" />
+          <Path path="571" as="551" dim="55" />
         </Paths>
       </Formula>
       <Formula id="VascularEndoVolume.VOLUME_VascularEndo_lje" name="VOLUME_VascularEndo_lje" dim="Volume" formula="SA_pls_int*d_endo">
         <Paths>
           <Path path="177" as="178" dim="127" />
-          <Path path="562" as="180" dim="181" />
+          <Path path="572" as="180" dim="181" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_lje" name="PARAM_K_Water_INT_lje" formula="K_water_int">
         <Paths>
-          <Path path="563" as="193" />
+          <Path path="573" as="193" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_lje" name="PARAM_K_Water_CELL_lje" formula="K_water_cell">
         <Paths>
-          <Path path="564" as="197" />
+          <Path path="574" as="197" />
         </Paths>
       </Formula>
       <Formula id="CompartmentsVolume_2Poren.VOLUME_end_lje" name="VOLUME_end_lje" dim="Volume" formula="f_endo*SA_pls_int*d_endo">
         <Paths>
           <Path path="199" as="200" dim="24" />
           <Path path="177" as="178" dim="127" />
-          <Path path="562" as="180" dim="181" />
+          <Path path="572" as="180" dim="181" />
         </Paths>
       </Formula>
       <Formula id="MucosaVolume.VOLUME_MucosaUpperIleum" name="VOLUME_MucosaUpperIleum" dim="Volume" formula="V_GutWall*fractionMucosa">
         <Paths>
-          <Path path="538" as="539" />
-          <Path path="565" as="541" dim="50" />
+          <Path path="548" as="549" />
+          <Path path="575" as="551" dim="55" />
         </Paths>
       </Formula>
       <Formula id="VascularEndoVolume.VOLUME_VascularEndo_uil" name="VOLUME_VascularEndo_uil" dim="Volume" formula="SA_pls_int*d_endo">
         <Paths>
           <Path path="177" as="178" dim="127" />
-          <Path path="566" as="180" dim="181" />
+          <Path path="576" as="180" dim="181" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_uil" name="PARAM_K_Water_INT_uil" formula="K_water_int">
         <Paths>
-          <Path path="567" as="193" />
+          <Path path="577" as="193" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_uil" name="PARAM_K_Water_CELL_uil" formula="K_water_cell">
         <Paths>
-          <Path path="568" as="197" />
+          <Path path="578" as="197" />
         </Paths>
       </Formula>
       <Formula id="CompartmentsVolume_2Poren.VOLUME_end_uil" name="VOLUME_end_uil" dim="Volume" formula="f_endo*SA_pls_int*d_endo">
         <Paths>
           <Path path="199" as="200" dim="24" />
           <Path path="177" as="178" dim="127" />
-          <Path path="566" as="180" dim="181" />
+          <Path path="576" as="180" dim="181" />
         </Paths>
       </Formula>
       <Formula id="MucosaVolume.VOLUME_MucosaLowerIleum" name="VOLUME_MucosaLowerIleum" dim="Volume" formula="V_GutWall*fractionMucosa">
         <Paths>
-          <Path path="538" as="539" />
-          <Path path="569" as="541" dim="50" />
+          <Path path="548" as="549" />
+          <Path path="579" as="551" dim="55" />
         </Paths>
       </Formula>
       <Formula id="VascularEndoVolume.VOLUME_VascularEndo_lil" name="VOLUME_VascularEndo_lil" dim="Volume" formula="SA_pls_int*d_endo">
         <Paths>
           <Path path="177" as="178" dim="127" />
-          <Path path="570" as="180" dim="181" />
+          <Path path="580" as="180" dim="181" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_lil" name="PARAM_K_Water_INT_lil" formula="K_water_int">
         <Paths>
-          <Path path="571" as="193" />
+          <Path path="581" as="193" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_lil" name="PARAM_K_Water_CELL_lil" formula="K_water_cell">
         <Paths>
-          <Path path="572" as="197" />
+          <Path path="582" as="197" />
         </Paths>
       </Formula>
       <Formula id="CompartmentsVolume_2Poren.VOLUME_end_lil" name="VOLUME_end_lil" dim="Volume" formula="f_endo*SA_pls_int*d_endo">
         <Paths>
           <Path path="199" as="200" dim="24" />
           <Path path="177" as="178" dim="127" />
-          <Path path="570" as="180" dim="181" />
+          <Path path="580" as="180" dim="181" />
         </Paths>
       </Formula>
-      <Formula id="MucosaVolume.VOLUME_LargeIntestineMucosa" name="VOLUME_LargeIntestineMucosa" dim="Volume" formula="V_cae+V_ca+V_ct+V_cd+V_cs+V_rec">
+      <Formula id="Lumen_PKSim.PARAM_LITT_Factor" name="PARAM_LITT_Factor" formula="P1*LITT+P2">
         <Paths>
-          <Path path="573" as="574" dim="50" />
-          <Path path="575" as="576" dim="50" />
-          <Path path="577" as="578" dim="50" />
-          <Path path="579" as="580" dim="50" />
-          <Path path="581" as="582" dim="50" />
-          <Path path="583" as="584" dim="50" />
+          <Path path="583" as="584" dim="146" />
+          <Path path="585" as="506" />
+          <Path path="586" as="508" dim="50" />
         </Paths>
       </Formula>
-      <Formula id="Lumen_PKSim.PARAM_LITT_Factor" name="PARAM_LITT_Factor" formula="P1*LITT+P2">
+      <Formula id="MucosaVolume.VOLUME_LargeIntestineMucosa" name="VOLUME_LargeIntestineMucosa" dim="Volume" formula="V_cae+V_ca+V_ct+V_cd+V_cs+V_rec">
         <Paths>
-          <Path path="585" as="586" dim="146" />
-          <Path path="587" as="496" />
-          <Path path="588" as="498" dim="111" />
+          <Path path="587" as="588" dim="55" />
+          <Path path="589" as="590" dim="55" />
+          <Path path="591" as="592" dim="55" />
+          <Path path="593" as="594" dim="55" />
+          <Path path="595" as="596" dim="55" />
+          <Path path="597" as="598" dim="55" />
         </Paths>
       </Formula>
-      <Formula id="VascularEndoVolume.VOLUME_VascularEndo_lin" name="VOLUME_VascularEndo_lin" dim="Volume" formula="SA_pls_int*d_endo">
+      <Formula id="Individual_PKSim.PARAM_FluidRecirculationRate_lin" name="PARAM_FluidRecirculationRate_lin" dim="Flow" formula="J_iso_incl_Mucosa-J_iso_cae-J_iso_colasc-J_iso_coltrans-J_iso_coldesc-J_iso_colsigm-J_iso_rect">
         <Paths>
-          <Path path="177" as="178" dim="127" />
-          <Path path="589" as="180" dim="181" />
+          <Path path="509" as="510" dim="168" />
+          <Path path="599" as="600" dim="168" />
+          <Path path="601" as="602" dim="168" />
+          <Path path="603" as="604" dim="168" />
+          <Path path="605" as="606" dim="168" />
+          <Path path="607" as="608" dim="168" />
+          <Path path="609" as="610" dim="168" />
         </Paths>
       </Formula>
       <Formula id="Individual_PKSim.PARAM_Q_Lymph_lin" name="PARAM_Q_Lymph_lin" dim="Flow" formula="Q_lymph_incl_Mucosa-Q_lymph_cae-Q_lymph_colasc-Q_lymph_coltrans-Q_lymph_coldesc-Q_lymph_colsigm-Q_lymph_rect">
         <Paths>
-          <Path path="512" as="513" dim="168" />
-          <Path path="590" as="591" dim="168" />
-          <Path path="592" as="593" dim="168" />
-          <Path path="594" as="595" dim="168" />
-          <Path path="596" as="597" dim="168" />
-          <Path path="598" as="599" dim="168" />
-          <Path path="600" as="601" dim="168" />
+          <Path path="521" as="522" dim="168" />
+          <Path path="611" as="612" dim="168" />
+          <Path path="613" as="614" dim="168" />
+          <Path path="615" as="616" dim="168" />
+          <Path path="617" as="618" dim="168" />
+          <Path path="619" as="620" dim="168" />
+          <Path path="621" as="622" dim="168" />
         </Paths>
       </Formula>
-      <Formula id="Individual_PKSim.PARAM_FluidRecirculationRate_lin" name="PARAM_FluidRecirculationRate_lin" dim="Flow" formula="J_iso_incl_Mucosa-J_iso_cae-J_iso_colasc-J_iso_coltrans-J_iso_coldesc-J_iso_colsigm-J_iso_rect">
+      <Formula id="VascularEndoVolume.VOLUME_VascularEndo_lin" name="VOLUME_VascularEndo_lin" dim="Volume" formula="SA_pls_int*d_endo">
         <Paths>
-          <Path path="499" as="500" dim="168" />
-          <Path path="602" as="603" dim="168" />
-          <Path path="604" as="605" dim="168" />
-          <Path path="606" as="607" dim="168" />
-          <Path path="608" as="609" dim="168" />
-          <Path path="610" as="611" dim="168" />
-          <Path path="612" as="613" dim="168" />
+          <Path path="177" as="178" dim="127" />
+          <Path path="623" as="180" dim="181" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_lin" name="PARAM_K_Water_INT_lin" formula="K_water_int">
         <Paths>
-          <Path path="614" as="193" />
+          <Path path="624" as="193" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_lin" name="PARAM_K_Water_CELL_lin" formula="K_water_cell">
         <Paths>
-          <Path path="615" as="197" />
+          <Path path="625" as="197" />
         </Paths>
       </Formula>
       <Formula id="CompartmentsVolume_2Poren.VOLUME_end_lin" name="VOLUME_end_lin" dim="Volume" formula="f_endo*SA_pls_int*d_endo">
         <Paths>
           <Path path="199" as="200" dim="24" />
           <Path path="177" as="178" dim="127" />
-          <Path path="589" as="180" dim="181" />
+          <Path path="623" as="180" dim="181" />
         </Paths>
       </Formula>
       <Formula id="MucosaVolume.VOLUME_MucosaCaecum" name="VOLUME_MucosaCaecum" dim="Volume" formula="V_GutWall*fractionMucosa">
         <Paths>
-          <Path path="538" as="539" />
-          <Path path="616" as="541" dim="50" />
+          <Path path="548" as="549" />
+          <Path path="626" as="551" dim="55" />
         </Paths>
       </Formula>
       <Formula id="VascularEndoVolume.VOLUME_VascularEndo_cae" name="VOLUME_VascularEndo_cae" dim="Volume" formula="SA_pls_int*d_endo">
         <Paths>
           <Path path="177" as="178" dim="127" />
-          <Path path="617" as="180" dim="181" />
+          <Path path="627" as="180" dim="181" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_cae" name="PARAM_K_Water_INT_cae" formula="K_water_int">
         <Paths>
-          <Path path="618" as="193" />
+          <Path path="628" as="193" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_cae" name="PARAM_K_Water_CELL_cae" formula="K_water_cell">
         <Paths>
-          <Path path="619" as="197" />
+          <Path path="629" as="197" />
         </Paths>
       </Formula>
       <Formula id="CompartmentsVolume_2Poren.VOLUME_end_cae" name="VOLUME_end_cae" dim="Volume" formula="f_endo*SA_pls_int*d_endo">
         <Paths>
           <Path path="199" as="200" dim="24" />
           <Path path="177" as="178" dim="127" />
-          <Path path="617" as="180" dim="181" />
+          <Path path="627" as="180" dim="181" />
         </Paths>
       </Formula>
       <Formula id="MucosaVolume.VOLUME_MucosaColonAscendens" name="VOLUME_MucosaColonAscendens" dim="Volume" formula="V_GutWall*fractionMucosa">
         <Paths>
-          <Path path="538" as="539" />
-          <Path path="620" as="541" dim="50" />
+          <Path path="548" as="549" />
+          <Path path="630" as="551" dim="55" />
         </Paths>
       </Formula>
       <Formula id="VascularEndoVolume.VOLUME_VascularEndo_colasc" name="VOLUME_VascularEndo_colasc" dim="Volume" formula="SA_pls_int*d_endo">
         <Paths>
           <Path path="177" as="178" dim="127" />
-          <Path path="621" as="180" dim="181" />
+          <Path path="631" as="180" dim="181" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_colasc" name="PARAM_K_Water_INT_colasc" formula="K_water_int">
         <Paths>
-          <Path path="622" as="193" />
+          <Path path="632" as="193" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_colasc" name="PARAM_K_Water_CELL_colasc" formula="K_water_cell">
         <Paths>
-          <Path path="623" as="197" />
+          <Path path="633" as="197" />
         </Paths>
       </Formula>
       <Formula id="CompartmentsVolume_2Poren.VOLUME_end_colasc" name="VOLUME_end_colasc" dim="Volume" formula="f_endo*SA_pls_int*d_endo">
         <Paths>
           <Path path="199" as="200" dim="24" />
           <Path path="177" as="178" dim="127" />
-          <Path path="621" as="180" dim="181" />
+          <Path path="631" as="180" dim="181" />
         </Paths>
       </Formula>
       <Formula id="MucosaVolume.VOLUME_MucosaColonTransversum" name="VOLUME_MucosaColonTransversum" dim="Volume" formula="V_GutWall*fractionMucosa">
         <Paths>
-          <Path path="538" as="539" />
-          <Path path="624" as="541" dim="50" />
+          <Path path="548" as="549" />
+          <Path path="634" as="551" dim="55" />
         </Paths>
       </Formula>
       <Formula id="VascularEndoVolume.VOLUME_VascularEndo_coltrans" name="VOLUME_VascularEndo_coltrans" dim="Volume" formula="SA_pls_int*d_endo">
         <Paths>
           <Path path="177" as="178" dim="127" />
-          <Path path="625" as="180" dim="181" />
+          <Path path="635" as="180" dim="181" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_coltrans" name="PARAM_K_Water_INT_coltrans" formula="K_water_int">
         <Paths>
-          <Path path="626" as="193" />
+          <Path path="636" as="193" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_coltrans" name="PARAM_K_Water_CELL_coltrans" formula="K_water_cell">
         <Paths>
-          <Path path="627" as="197" />
+          <Path path="637" as="197" />
         </Paths>
       </Formula>
       <Formula id="CompartmentsVolume_2Poren.VOLUME_end_coltrans" name="VOLUME_end_coltrans" dim="Volume" formula="f_endo*SA_pls_int*d_endo">
         <Paths>
           <Path path="199" as="200" dim="24" />
           <Path path="177" as="178" dim="127" />
-          <Path path="625" as="180" dim="181" />
+          <Path path="635" as="180" dim="181" />
         </Paths>
       </Formula>
       <Formula id="MucosaVolume.VOLUME_MucosaColonDescendens" name="VOLUME_MucosaColonDescendens" dim="Volume" formula="V_GutWall*fractionMucosa">
         <Paths>
-          <Path path="538" as="539" />
-          <Path path="628" as="541" dim="50" />
+          <Path path="548" as="549" />
+          <Path path="638" as="551" dim="55" />
         </Paths>
       </Formula>
       <Formula id="VascularEndoVolume.VOLUME_VascularEndo_coldesc" name="VOLUME_VascularEndo_coldesc" dim="Volume" formula="SA_pls_int*d_endo">
         <Paths>
           <Path path="177" as="178" dim="127" />
-          <Path path="629" as="180" dim="181" />
+          <Path path="639" as="180" dim="181" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_coldesc" name="PARAM_K_Water_INT_coldesc" formula="K_water_int">
         <Paths>
-          <Path path="630" as="193" />
+          <Path path="640" as="193" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_coldesc" name="PARAM_K_Water_CELL_coldesc" formula="K_water_cell">
         <Paths>
-          <Path path="631" as="197" />
+          <Path path="641" as="197" />
         </Paths>
       </Formula>
       <Formula id="CompartmentsVolume_2Poren.VOLUME_end_coldesc" name="VOLUME_end_coldesc" dim="Volume" formula="f_endo*SA_pls_int*d_endo">
         <Paths>
           <Path path="199" as="200" dim="24" />
           <Path path="177" as="178" dim="127" />
-          <Path path="629" as="180" dim="181" />
+          <Path path="639" as="180" dim="181" />
         </Paths>
       </Formula>
       <Formula id="MucosaVolume.VOLUME_MucosaColonSigmoid" name="VOLUME_MucosaColonSigmoid" dim="Volume" formula="V_GutWall*fractionMucosa">
         <Paths>
-          <Path path="538" as="539" />
-          <Path path="632" as="541" dim="50" />
+          <Path path="548" as="549" />
+          <Path path="642" as="551" dim="55" />
         </Paths>
       </Formula>
       <Formula id="VascularEndoVolume.VOLUME_VascularEndo_colsigm" name="VOLUME_VascularEndo_colsigm" dim="Volume" formula="SA_pls_int*d_endo">
         <Paths>
           <Path path="177" as="178" dim="127" />
-          <Path path="633" as="180" dim="181" />
+          <Path path="643" as="180" dim="181" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_colsigm" name="PARAM_K_Water_INT_colsigm" formula="K_water_int">
         <Paths>
-          <Path path="634" as="193" />
+          <Path path="644" as="193" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_colsigm" name="PARAM_K_Water_CELL_colsigm" formula="K_water_cell">
         <Paths>
-          <Path path="635" as="197" />
+          <Path path="645" as="197" />
         </Paths>
       </Formula>
       <Formula id="CompartmentsVolume_2Poren.VOLUME_end_colsigm" name="VOLUME_end_colsigm" dim="Volume" formula="f_endo*SA_pls_int*d_endo">
         <Paths>
           <Path path="199" as="200" dim="24" />
           <Path path="177" as="178" dim="127" />
-          <Path path="633" as="180" dim="181" />
+          <Path path="643" as="180" dim="181" />
         </Paths>
       </Formula>
       <Formula id="MucosaVolume.VOLUME_MucosaRectum" name="VOLUME_MucosaRectum" dim="Volume" formula="V_GutWall*fractionMucosa">
         <Paths>
-          <Path path="538" as="539" />
-          <Path path="636" as="541" dim="50" />
+          <Path path="548" as="549" />
+          <Path path="646" as="551" dim="55" />
         </Paths>
       </Formula>
       <Formula id="VascularEndoVolume.VOLUME_VascularEndo_rect" name="VOLUME_VascularEndo_rect" dim="Volume" formula="SA_pls_int*d_endo">
         <Paths>
           <Path path="177" as="178" dim="127" />
-          <Path path="637" as="180" dim="181" />
+          <Path path="647" as="180" dim="181" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_rect" name="PARAM_K_Water_INT_rect" formula="K_water_int">
         <Paths>
-          <Path path="638" as="193" />
+          <Path path="648" as="193" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_rect" name="PARAM_K_Water_CELL_rect" formula="K_water_cell">
         <Paths>
-          <Path path="639" as="197" />
+          <Path path="649" as="197" />
         </Paths>
       </Formula>
       <Formula id="CompartmentsVolume_2Poren.VOLUME_end_rect" name="VOLUME_end_rect" dim="Volume" formula="f_endo*SA_pls_int*d_endo">
         <Paths>
           <Path path="199" as="200" dim="24" />
           <Path path="177" as="178" dim="127" />
-          <Path path="637" as="180" dim="181" />
+          <Path path="647" as="180" dim="181" />
         </Paths>
       </Formula>
       <Formula id="VascularEndoVolume.VOLUME_VascularEndo_liv" name="VOLUME_VascularEndo_liv" dim="Volume" formula="SA_pls_int*d_endo">
         <Paths>
           <Path path="177" as="178" dim="127" />
-          <Path path="640" as="180" dim="181" />
+          <Path path="650" as="180" dim="181" />
         </Paths>
       </Formula>
       <Formula id="EndosomalSpaceBindingFormulas.PARAM_f_uptake_vas_LiverZone" name="PARAM_f_uptake_vas_LiverZone" dim="Fraction" formula="Liver_Parameter">
         <Paths>
-          <Path path="641" as="642" dim="24" />
+          <Path path="651" as="652" dim="24" />
         </Paths>
       </Formula>
-      <Formula id="EndosomalSpaceBindingFormulas.PARAM_K_rec_LiverZone" name="PARAM_K_rec_LiverZone" dim="Inversed time" formula="Liver_Parameter">
+      <Formula id="Individual_PKSim.PARAM_Allometric scale factor_LiverZone" name="PARAM_Allometric scale factor_LiverZone" formula="Liver_Parameter">
         <Paths>
-          <Path path="643" as="642" dim="111" />
+          <Path path="653" as="652" />
         </Paths>
       </Formula>
-      <Formula id="EndosomalSpaceBindingFormulas.PARAM_K_uptake_LiverZone" name="PARAM_K_uptake_LiverZone" dim="Inversed time" formula="Liver_Parameter">
+      <Formula id="Individual_PKSim.PARAM_Density (tissue)_LiverZone" name="PARAM_Density (tissue)_LiverZone" dim="Density" formula="Liver_Parameter">
         <Paths>
-          <Path path="644" as="642" dim="111" />
+          <Path path="654" as="652" dim="133" />
         </Paths>
       </Formula>
-      <Formula id="EndosomalSpaceBindingFormulas.PARAM_f_rec_vas_LiverZone" name="PARAM_f_rec_vas_LiverZone" dim="Fraction" formula="Liver_Parameter">
+      <Formula id="EndosomalSpaceBindingFormulas.PARAM_f_endo_LiverZone" name="PARAM_f_endo_LiverZone" dim="Fraction" formula="Liver_Parameter">
         <Paths>
-          <Path path="645" as="642" dim="24" />
+          <Path path="199" as="652" dim="24" />
         </Paths>
       </Formula>
       <Formula id="Individual_PKSim.PARAM_Fraction of blood for sampling_LiverZone" name="PARAM_Fraction of blood for sampling_LiverZone" formula="Liver_Parameter">
         <Paths>
-          <Path path="646" as="642" />
+          <Path path="655" as="652" />
         </Paths>
       </Formula>
-      <Formula id="EndosomalSpaceBindingFormulas.PARAM_f_endo_LiverZone" name="PARAM_f_endo_LiverZone" dim="Fraction" formula="Liver_Parameter">
+      <Formula id="EndosomalSpaceBindingFormulas.PARAM_f_rec_vas_LiverZone" name="PARAM_f_rec_vas_LiverZone" dim="Fraction" formula="Liver_Parameter">
         <Paths>
-          <Path path="199" as="642" dim="24" />
+          <Path path="656" as="652" dim="24" />
         </Paths>
       </Formula>
-      <Formula id="Individual_PKSim.PARAM_Density (tissue)_LiverZone" name="PARAM_Density (tissue)_LiverZone" dim="Density" formula="Liver_Parameter">
+      <Formula id="EndosomalSpaceBindingFormulas.PARAM_K_uptake_LiverZone" name="PARAM_K_uptake_LiverZone" dim="Inversed time" formula="Liver_Parameter">
         <Paths>
-          <Path path="647" as="642" dim="133" />
+          <Path path="657" as="652" dim="50" />
         </Paths>
       </Formula>
-      <Formula id="Individual_PKSim.PARAM_Allometric scale factor_LiverZone" name="PARAM_Allometric scale factor_LiverZone" formula="Liver_Parameter">
+      <Formula id="EndosomalSpaceBindingFormulas.PARAM_K_rec_LiverZone" name="PARAM_K_rec_LiverZone" dim="Inversed time" formula="Liver_Parameter">
         <Paths>
-          <Path path="648" as="642" />
+          <Path path="658" as="652" dim="50" />
         </Paths>
       </Formula>
       <Formula id="Individual_PKSim.PARAM_Volume_Periportal" name="PARAM_Volume_Periportal" dim="Volume" formula="V_liv * (IsLiverZonated ? f_periportal : 1)">
         <Paths>
-          <Path path="649" as="650" dim="24" />
-          <Path path="651" as="652" />
-          <Path path="653" as="654" dim="50" />
+          <Path path="659" as="660" dim="24" />
+          <Path path="661" as="662" />
+          <Path path="663" as="664" dim="55" />
         </Paths>
       </Formula>
-      <Formula id="Individual_PKSim.PARAM_Radius (small pores)_LiverZone" name="PARAM_Radius (small pores)_LiverZone" dim="Length" formula="Liver_Parameter">
+      <Formula id="Individual_PKSim.PARAM_Flow fraction via large pores_LiverZone" name="PARAM_Flow fraction via large pores_LiverZone" formula="Liver_Parameter">
         <Paths>
-          <Path path="655" as="642" dim="127" />
+          <Path path="665" as="652" />
         </Paths>
       </Formula>
-      <Formula id="Individual_PKSim.PARAM_Radius (large pores)_LiverZone" name="PARAM_Radius (large pores)_LiverZone" dim="Length" formula="Liver_Parameter">
+      <Formula id="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate_Liver_Periportal" name="PARAM_Fluid_recirculation_flow_rate_Liver_Periportal" dim="Flow" formula="J_iso * (IsLiverZonated?  f_periportal : 1)">
         <Paths>
-          <Path path="656" as="642" dim="127" />
+          <Path path="666" as="667" dim="168" />
+          <Path path="659" as="660" dim="24" />
+          <Path path="661" as="662" />
         </Paths>
       </Formula>
-      <Formula id="VascularEndoVolume.VOLUME_VascularEndo_liv_periportal" name="VOLUME_VascularEndo_liv_periportal" dim="Volume" formula="SA_pls_int*d_endo">
+      <Formula id="Individual_PKSim.PARAM_Hydraulic conductivity_LiverZone" name="PARAM_Hydraulic conductivity_LiverZone" dim="Hydraulic conductivity" formula="Liver_Parameter">
         <Paths>
-          <Path path="177" as="178" dim="127" />
-          <Path path="657" as="180" dim="181" />
+          <Path path="668" as="652" dim="669" />
         </Paths>
       </Formula>
       <Formula id="Individual_PKSim.PARAM_Lymph_flow_rate_Liver_Periportal" name="PARAM_Lymph_flow_rate_Liver_Periportal" dim="Flow" formula="Q_lymph * (IsLiverZonated?  f_periportal : 1)">
         <Paths>
-          <Path path="658" as="167" dim="168" />
-          <Path path="649" as="650" dim="24" />
-          <Path path="651" as="652" />
+          <Path path="670" as="167" dim="168" />
+          <Path path="659" as="660" dim="24" />
+          <Path path="661" as="662" />
         </Paths>
       </Formula>
-      <Formula id="Individual_PKSim.PARAM_Hydraulic conductivity_LiverZone" name="PARAM_Hydraulic conductivity_LiverZone" dim="Hydraulic conductivity" formula="Liver_Parameter">
+      <Formula id="Individual_PKSim.PARAM_Radius (large pores)_LiverZone" name="PARAM_Radius (large pores)_LiverZone" dim="Length" formula="Liver_Parameter">
         <Paths>
-          <Path path="659" as="642" dim="660" />
+          <Path path="671" as="652" dim="127" />
         </Paths>
       </Formula>
-      <Formula id="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate_Liver_Periportal" name="PARAM_Fluid_recirculation_flow_rate_Liver_Periportal" dim="Flow" formula="J_iso * (IsLiverZonated?  f_periportal : 1)">
+      <Formula id="Individual_PKSim.PARAM_Radius (small pores)_LiverZone" name="PARAM_Radius (small pores)_LiverZone" dim="Length" formula="Liver_Parameter">
         <Paths>
-          <Path path="661" as="662" dim="168" />
-          <Path path="649" as="650" dim="24" />
-          <Path path="651" as="652" />
+          <Path path="672" as="652" dim="127" />
         </Paths>
       </Formula>
-      <Formula id="Individual_PKSim.PARAM_Flow fraction via large pores_LiverZone" name="PARAM_Flow fraction via large pores_LiverZone" formula="Liver_Parameter">
+      <Formula id="VascularEndoVolume.VOLUME_VascularEndo_liv_periportal" name="VOLUME_VascularEndo_liv_periportal" dim="Volume" formula="SA_pls_int*d_endo">
         <Paths>
-          <Path path="663" as="642" />
+          <Path path="177" as="178" dim="127" />
+          <Path path="673" as="180" dim="181" />
         </Paths>
       </Formula>
-      <Formula id="Individual_PKSim.PARAM_Vf (neutral lipid)-PT_LiverZone" name="PARAM_Vf (neutral lipid)-PT_LiverZone" formula="Liver_Parameter">
+      <Formula id="Individual_PKSim.PARAM_Vf (lipid)_LiverZone" name="PARAM_Vf (lipid)_LiverZone" formula="Liver_Parameter">
         <Paths>
-          <Path path="664" as="642" />
+          <Path path="674" as="652" />
         </Paths>
       </Formula>
-      <Formula id="Individual_PKSim.PARAM_Vf (lipid)_LiverZone" name="PARAM_Vf (lipid)_LiverZone" formula="Liver_Parameter">
+      <Formula id="Individual_PKSim.PARAM_Vf (neutral lipid)-PT_LiverZone" name="PARAM_Vf (neutral lipid)-PT_LiverZone" formula="Liver_Parameter">
         <Paths>
-          <Path path="665" as="642" />
+          <Path path="675" as="652" />
         </Paths>
       </Formula>
       <Formula id="Individual_PKSim.PARAM_Vf (phospholipid)-PT_LiverZone" name="PARAM_Vf (phospholipid)-PT_LiverZone" formula="Liver_Parameter">
         <Paths>
-          <Path path="666" as="642" />
+          <Path path="676" as="652" />
         </Paths>
       </Formula>
       <Formula id="Individual_PKSim.PARAM_Vf (protein)_LiverZone" name="PARAM_Vf (protein)_LiverZone" formula="Liver_Parameter">
         <Paths>
-          <Path path="667" as="642" />
+          <Path path="677" as="652" />
         </Paths>
       </Formula>
       <Formula id="Individual_PKSim.PARAM_Albumin ratio (tissue/plasma)_LiverZone" name="PARAM_Albumin ratio (tissue/plasma)_LiverZone" formula="Liver_Parameter">
         <Paths>
-          <Path path="668" as="642" />
+          <Path path="678" as="652" />
         </Paths>
       </Formula>
-      <Formula id="Individual_PKSim.PARAM_Lipoprotein ratio (tissue/plasma)_LiverZone" name="PARAM_Lipoprotein ratio (tissue/plasma)_LiverZone" formula="Liver_Parameter">
+      <Formula id="Individual_PKSim.PARAM_Albumin ratio (tissue/plasma)-PT_LiverZone" name="PARAM_Albumin ratio (tissue/plasma)-PT_LiverZone" formula="Liver_Parameter">
         <Paths>
-          <Path path="669" as="642" />
+          <Path path="679" as="652" />
         </Paths>
       </Formula>
-      <Formula id="Individual_PKSim.PARAM_Vf (water)-PT_LiverZone" name="PARAM_Vf (water)-PT_LiverZone" formula="Liver_Parameter">
+      <Formula id="Individual_PKSim.PARAM_Fraction vascular_LiverZone" name="PARAM_Fraction vascular_LiverZone" formula="Liver_Parameter">
         <Paths>
-          <Path path="670" as="642" />
+          <Path path="135" as="652" />
         </Paths>
       </Formula>
-      <Formula id="Individual_PKSim.PARAM_Number of cells/g tissue_LiverZone" name="PARAM_Number of cells/g tissue_LiverZone" dim="Count per mass" formula="Liver_Parameter">
+      <Formula id="Individual_PKSim.PARAM_Lipoprotein ratio (tissue/plasma)_LiverZone" name="PARAM_Lipoprotein ratio (tissue/plasma)_LiverZone" formula="Liver_Parameter">
         <Paths>
-          <Path path="671" as="642" dim="672" />
+          <Path path="680" as="652" />
         </Paths>
       </Formula>
       <Formula id="Individual_PKSim.PARAM_Microsomal protein mass/g tissue_LiverZone" name="PARAM_Microsomal protein mass/g tissue_LiverZone" dim="Mass per tissue" formula="Liver_Parameter">
         <Paths>
-          <Path path="673" as="642" dim="674" />
+          <Path path="681" as="652" dim="682" />
         </Paths>
       </Formula>
-      <Formula id="Individual_PKSim.PARAM_Albumin ratio (tissue/plasma)-PT_LiverZone" name="PARAM_Albumin ratio (tissue/plasma)-PT_LiverZone" formula="Liver_Parameter">
+      <Formula id="Individual_PKSim.PARAM_Number of cells/g tissue_LiverZone" name="PARAM_Number of cells/g tissue_LiverZone" dim="Count per mass" formula="Liver_Parameter">
         <Paths>
-          <Path path="675" as="642" />
+          <Path path="683" as="652" dim="684" />
         </Paths>
       </Formula>
-      <Formula id="Individual_PKSim.PARAM_Fraction vascular_LiverZone" name="PARAM_Fraction vascular_LiverZone" formula="Liver_Parameter">
+      <Formula id="Individual_PKSim.PARAM_Vf (water)_LiverZone" name="PARAM_Vf (water)_LiverZone" formula="Liver_Parameter">
         <Paths>
-          <Path path="135" as="642" />
+          <Path path="685" as="652" />
         </Paths>
       </Formula>
-      <Formula id="Individual_PKSim.PARAM_Vf (water)_LiverZone" name="PARAM_Vf (water)_LiverZone" formula="Liver_Parameter">
+      <Formula id="Individual_PKSim.PARAM_Vf (water)-PT_LiverZone" name="PARAM_Vf (water)-PT_LiverZone" formula="Liver_Parameter">
         <Paths>
-          <Path path="676" as="642" />
+          <Path path="686" as="652" />
         </Paths>
       </Formula>
       <Formula id="Individual_PKSim.PARAM_f_cell_LiverZone" name="PARAM_f_cell_LiverZone" formula="Liver_Parameter">
         <Paths>
-          <Path path="194" as="642" />
+          <Path path="194" as="652" />
         </Paths>
       </Formula>
       <Formula id="Individual_PKSim.PARAM_Fraction interstitial_LiverZone" name="PARAM_Fraction interstitial_LiverZone" formula="Liver_Parameter">
         <Paths>
-          <Path path="189" as="642" />
+          <Path path="189" as="652" />
         </Paths>
       </Formula>
       <Formula id="Individual_PKSim.PARAM_Vf (neutral lipid)-RR_LiverZone" name="PARAM_Vf (neutral lipid)-RR_LiverZone" formula="Liver_Parameter">
         <Paths>
-          <Path path="677" as="642" />
+          <Path path="687" as="652" />
         </Paths>
       </Formula>
       <Formula id="Individual_PKSim.PARAM_Vf (neutral lipid)-WS_LiverZone" name="PARAM_Vf (neutral lipid)-WS_LiverZone" formula="Liver_Parameter">
         <Paths>
-          <Path path="678" as="642" />
+          <Path path="688" as="652" />
         </Paths>
       </Formula>
       <Formula id="Individual_PKSim.PARAM_Vf (neutral phospholipid)-RR_LiverZone" name="PARAM_Vf (neutral phospholipid)-RR_LiverZone" formula="Liver_Parameter">
         <Paths>
-          <Path path="679" as="642" />
+          <Path path="689" as="652" />
         </Paths>
       </Formula>
       <Formula id="Individual_PKSim.PARAM_Vf (neutral phospholipid, plasma)-WS_LiverZone" name="PARAM_Vf (neutral phospholipid, plasma)-WS_LiverZone" formula="Liver_Parameter">
         <Paths>
-          <Path path="680" as="642" />
+          <Path path="690" as="652" />
         </Paths>
       </Formula>
-      <Formula id="Individual_PKSim.PARAM_Vf (protein)-WS_LiverZone" name="PARAM_Vf (protein)-WS_LiverZone" formula="Liver_Parameter">
+      <Formula id="Individual_PKSim.PARAM_Vf (extracellular water)-RR_LiverZone" name="PARAM_Vf (extracellular water)-RR_LiverZone" formula="Liver_Parameter">
         <Paths>
-          <Path path="681" as="642" />
+          <Path path="691" as="652" />
         </Paths>
       </Formula>
-      <Formula id="Individual_PKSim.PARAM_Vf (extracellular water)-RR_LiverZone" name="PARAM_Vf (extracellular water)-RR_LiverZone" formula="Liver_Parameter">
+      <Formula id="Individual_PKSim.PARAM_Vf (protein)-WS_LiverZone" name="PARAM_Vf (protein)-WS_LiverZone" formula="Liver_Parameter">
         <Paths>
-          <Path path="682" as="642" />
+          <Path path="692" as="652" />
         </Paths>
       </Formula>
-      <Formula id="Individual_PKSim.PARAM_Vf (water)-WS_LiverZone" name="PARAM_Vf (water)-WS_LiverZone" formula="Liver_Parameter">
+      <Formula id="Individual_PKSim.PARAM_Vf (intracellular water)-RR_LiverZone" name="PARAM_Vf (intracellular water)-RR_LiverZone" formula="Liver_Parameter">
         <Paths>
-          <Path path="683" as="642" />
+          <Path path="693" as="652" />
         </Paths>
       </Formula>
-      <Formula id="Individual_PKSim.PARAM_Vf (intracellular water)-RR_LiverZone" name="PARAM_Vf (intracellular water)-RR_LiverZone" formula="Liver_Parameter">
+      <Formula id="Individual_PKSim.PARAM_Vf (water)-WS_LiverZone" name="PARAM_Vf (water)-WS_LiverZone" formula="Liver_Parameter">
         <Paths>
-          <Path path="684" as="642" />
+          <Path path="694" as="652" />
         </Paths>
       </Formula>
       <Formula id="Individual_PKSim.PARAM_Acidic phospholipids [mg/g] - RR_LiverZone" name="PARAM_Acidic phospholipids [mg/g] - RR_LiverZone" formula="Liver_Parameter">
         <Paths>
-          <Path path="685" as="642" />
+          <Path path="695" as="652" />
         </Paths>
       </Formula>
       <Formula id="Individual_PKSim.PARAM_Vf (acidic phospholipids)-WS_LiverZone" name="PARAM_Vf (acidic phospholipids)-WS_LiverZone" formula="Liver_Parameter">
         <Paths>
-          <Path path="686" as="642" />
+          <Path path="696" as="652" />
         </Paths>
       </Formula>
       <Formula id="Individual_PKSim.PARAM_Specific blood flow rate_LiverZone" name="PARAM_Specific blood flow rate_LiverZone" dim="Flow per weight organ" formula="Liver_Parameter">
         <Paths>
-          <Path path="687" as="642" dim="159" />
+          <Path path="697" as="652" dim="159" />
         </Paths>
       </Formula>
       <Formula id="Individual_PKSim.PARAM_Q_from_Qspec_LiverZone" name="PARAM_Q_from_Qspec_LiverZone" dim="Flow" formula="Liver_Parameter">
         <Paths>
-          <Path path="688" as="642" dim="168" />
+          <Path path="698" as="652" dim="168" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_liv" name="PARAM_K_Water_INT_liv" formula="K_water_int">
         <Paths>
-          <Path path="689" as="193" />
+          <Path path="699" as="193" />
         </Paths>
       </Formula>
       <Formula id="Individual_PKSim.PARAM_PH_Cell_LiverZone" name="PARAM_PH_Cell_LiverZone" formula="pH_cell_Liver">
         <Paths>
-          <Path path="690" as="691" />
+          <Path path="700" as="701" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_liv" name="PARAM_K_Water_CELL_liv" formula="K_water_cell">
         <Paths>
-          <Path path="692" as="197" />
+          <Path path="702" as="197" />
         </Paths>
       </Formula>
       <Formula id="CompartmentsVolume_2Poren.VOLUME_end_liv_periportal" name="VOLUME_end_liv_periportal" dim="Volume" formula="f_endo*SA_pls_int*d_endo">
         <Paths>
           <Path path="199" as="200" dim="24" />
           <Path path="177" as="178" dim="127" />
-          <Path path="657" as="180" dim="181" />
+          <Path path="673" as="180" dim="181" />
         </Paths>
       </Formula>
       <Formula id="Individual_PKSim.PARAM_Volume_Pericentral" name="PARAM_Volume_Pericentral" dim="Volume" formula="V_liv * (IsLiverZonated ? 1 - f_periportal : 0)">
         <Paths>
-          <Path path="649" as="650" dim="24" />
-          <Path path="651" as="652" />
-          <Path path="653" as="654" dim="50" />
+          <Path path="659" as="660" dim="24" />
+          <Path path="661" as="662" />
+          <Path path="663" as="664" dim="55" />
         </Paths>
       </Formula>
-      <Formula id="Individual_PKSim.PARAM_Lymph_flow_rate_Liver_Pericentral" name="PARAM_Lymph_flow_rate_Liver_Pericentral" dim="Flow" formula="Q_lymph * (IsLiverZonated?  1-f_periportal : 0)">
+      <Formula id="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate_Liver_Pericentral" name="PARAM_Fluid_recirculation_flow_rate_Liver_Pericentral" dim="Flow" formula="J_iso * (IsLiverZonated?  1-f_periportal : 0)">
         <Paths>
-          <Path path="658" as="167" dim="168" />
-          <Path path="649" as="650" dim="24" />
-          <Path path="651" as="652" />
+          <Path path="666" as="667" dim="168" />
+          <Path path="659" as="660" dim="24" />
+          <Path path="661" as="662" />
         </Paths>
       </Formula>
-      <Formula id="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate_Liver_Pericentral" name="PARAM_Fluid_recirculation_flow_rate_Liver_Pericentral" dim="Flow" formula="J_iso * (IsLiverZonated?  1-f_periportal : 0)">
+      <Formula id="Individual_PKSim.PARAM_Lymph_flow_rate_Liver_Pericentral" name="PARAM_Lymph_flow_rate_Liver_Pericentral" dim="Flow" formula="Q_lymph * (IsLiverZonated?  1-f_periportal : 0)">
         <Paths>
-          <Path path="661" as="662" dim="168" />
-          <Path path="649" as="650" dim="24" />
-          <Path path="651" as="652" />
+          <Path path="670" as="167" dim="168" />
+          <Path path="659" as="660" dim="24" />
+          <Path path="661" as="662" />
         </Paths>
       </Formula>
       <Formula id="VascularEndoVolume.VOLUME_VascularEndo_liv_pericentral" name="VOLUME_VascularEndo_liv_pericentral" dim="Volume" formula="SA_pls_int*d_endo">
         <Paths>
           <Path path="177" as="178" dim="127" />
-          <Path path="693" as="180" dim="181" />
+          <Path path="703" as="180" dim="181" />
         </Paths>
       </Formula>
       <Formula id="CompartmentsVolume_2Poren.VOLUME_end_liv_pericentral" name="VOLUME_end_liv_pericentral" dim="Volume" formula="f_endo*SA_pls_int*d_endo">
         <Paths>
           <Path path="199" as="200" dim="24" />
           <Path path="177" as="178" dim="127" />
-          <Path path="693" as="180" dim="181" />
+          <Path path="703" as="180" dim="181" />
         </Paths>
       </Formula>
       <Formula id="CompartmentsVolume_2Poren.VOLUME_end_liv" name="VOLUME_end_liv" dim="Volume" formula="f_endo*SA_pls_int*d_endo">
         <Paths>
           <Path path="199" as="200" dim="24" />
           <Path path="177" as="178" dim="127" />
-          <Path path="640" as="180" dim="181" />
+          <Path path="650" as="180" dim="181" />
         </Paths>
       </Formula>
       <Formula id="VascularEndoVolume.VOLUME_VascularEndo_lng" name="VOLUME_VascularEndo_lng" dim="Volume" formula="SA_pls_int*d_endo">
         <Paths>
           <Path path="177" as="178" dim="127" />
-          <Path path="694" as="180" dim="181" />
-        </Paths>
-      </Formula>
-      <Formula id="Individual_PKSim.PARAM_Q_lng" name="PARAM_Q_lng" dim="Flow" formula="Q_sto + Q_sin + Q_lin + Q_pan + Q_spl + Q_liv + Q_mus + Q_fat + Q_skn + Q_kid + Q_brn + Q_hrt + Q_bon + Q_tes">
-        <Paths>
-          <Path path="695" as="696" dim="168" />
-          <Path path="697" as="698" dim="168" />
-          <Path path="699" as="700" dim="168" />
-          <Path path="701" as="702" dim="168" />
-          <Path path="703" as="704" dim="168" />
-          <Path path="705" as="706" dim="168" />
-          <Path path="707" as="708" dim="168" />
-          <Path path="709" as="710" dim="168" />
-          <Path path="711" as="712" dim="168" />
-          <Path path="713" as="714" dim="168" />
-          <Path path="715" as="716" dim="168" />
-          <Path path="717" as="718" dim="168" />
-          <Path path="719" as="720" dim="168" />
-          <Path path="721" as="722" dim="168" />
+          <Path path="704" as="180" dim="181" />
         </Paths>
       </Formula>
+      <SumFormula id="DynamicSumFormulas.PARAM_Q_lng" name="PARAM_Q_lng" dim="Flow" variable="Q" formulaString="Q_#i">
+        <Criteria>
+          <DescriptorConditions>
+            <InContainerCondition tag="TissueOrgan" />
+            <NotInContainerCondition tag="Lung" />
+            <NotInContainerCondition tag="Pericentral" />
+            <MatchTagCondition tag="Blood flow rate" />
+            <NotInContainerCondition tag="Mucosa" />
+          </DescriptorConditions>
+        </Criteria>
+      </SumFormula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_lng" name="PARAM_K_Water_INT_lng" formula="K_water_int">
         <Paths>
-          <Path path="723" as="193" />
+          <Path path="705" as="193" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_lng" name="PARAM_K_Water_CELL_lng" formula="K_water_cell">
         <Paths>
-          <Path path="724" as="197" />
+          <Path path="706" as="197" />
         </Paths>
       </Formula>
       <Formula id="CompartmentsVolume_2Poren.VOLUME_end_lng" name="VOLUME_end_lng" dim="Volume" formula="f_endo*SA_pls_int*d_endo">
         <Paths>
           <Path path="199" as="200" dim="24" />
           <Path path="177" as="178" dim="127" />
-          <Path path="694" as="180" dim="181" />
+          <Path path="704" as="180" dim="181" />
         </Paths>
       </Formula>
       <Formula id="VascularEndoVolume.VOLUME_VascularEndo_mus" name="VOLUME_VascularEndo_mus" dim="Volume" formula="SA_pls_int*d_endo">
         <Paths>
           <Path path="177" as="178" dim="127" />
-          <Path path="725" as="180" dim="181" />
+          <Path path="707" as="180" dim="181" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_mus" name="PARAM_K_Water_INT_mus" formula="K_water_int">
         <Paths>
-          <Path path="726" as="193" />
+          <Path path="708" as="193" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_mus" name="PARAM_K_Water_CELL_mus" formula="K_water_cell">
         <Paths>
-          <Path path="727" as="197" />
+          <Path path="709" as="197" />
         </Paths>
       </Formula>
       <Formula id="CompartmentsVolume_2Poren.VOLUME_end_mus" name="VOLUME_end_mus" dim="Volume" formula="f_endo*SA_pls_int*d_endo">
         <Paths>
           <Path path="199" as="200" dim="24" />
           <Path path="177" as="178" dim="127" />
-          <Path path="725" as="180" dim="181" />
+          <Path path="707" as="180" dim="181" />
         </Paths>
       </Formula>
       <Formula id="VascularEndoVolume.VOLUME_VascularEndo_pan" name="VOLUME_VascularEndo_pan" dim="Volume" formula="SA_pls_int*d_endo">
         <Paths>
           <Path path="177" as="178" dim="127" />
-          <Path path="728" as="180" dim="181" />
+          <Path path="710" as="180" dim="181" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_pan" name="PARAM_K_Water_INT_pan" formula="K_water_int">
         <Paths>
-          <Path path="729" as="193" />
+          <Path path="711" as="193" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_pan" name="PARAM_K_Water_CELL_pan" formula="K_water_cell">
         <Paths>
-          <Path path="730" as="197" />
+          <Path path="712" as="197" />
         </Paths>
       </Formula>
       <Formula id="CompartmentsVolume_2Poren.VOLUME_end_pan" name="VOLUME_end_pan" dim="Volume" formula="f_endo*SA_pls_int*d_endo">
         <Paths>
           <Path path="199" as="200" dim="24" />
           <Path path="177" as="178" dim="127" />
-          <Path path="728" as="180" dim="181" />
+          <Path path="710" as="180" dim="181" />
         </Paths>
       </Formula>
       <Formula id="Individual_PKSim.PARAM_Q_Lymph_pve" name="PARAM_Q_Lymph_pve" dim="Flow" formula="Q_Lymph_sto + Q_Lymph_sin_incl_Mucosa + Q_Lymph_lin_incl_Mucosa + Q_Lymph_pan + Q_Lymph_spl">
         <Paths>
-          <Path path="731" as="732" dim="168" />
-          <Path path="733" as="734" dim="168" />
-          <Path path="735" as="736" dim="168" />
-          <Path path="737" as="738" dim="168" />
-          <Path path="739" as="740" dim="168" />
-        </Paths>
-      </Formula>
-      <Formula id="Individual_PKSim.PARAM_Q_pve" name="PARAM_Q_pve" dim="Flow" formula="Q_sto + Q_sin + Q_lin + Q_pan + Q_spl">
-        <Paths>
-          <Path path="707" as="708" dim="168" />
           <Path path="713" as="714" dim="168" />
+          <Path path="715" as="716" dim="168" />
           <Path path="717" as="718" dim="168" />
           <Path path="719" as="720" dim="168" />
           <Path path="721" as="722" dim="168" />
         </Paths>
       </Formula>
+      <Formula id="Individual_PKSim.PARAM_Q_pve" name="PARAM_Q_pve" dim="Flow" formula="Q_sto + Q_sin + Q_lin + Q_pan + Q_spl">
+        <Paths>
+          <Path path="723" as="724" dim="168" />
+          <Path path="725" as="726" dim="168" />
+          <Path path="727" as="728" dim="168" />
+          <Path path="729" as="730" dim="168" />
+          <Path path="731" as="732" dim="168" />
+        </Paths>
+      </Formula>
       <Formula id="VascularEndoVolume.VOLUME_VascularEndo_skn" name="VOLUME_VascularEndo_skn" dim="Volume" formula="SA_pls_int*d_endo">
         <Paths>
           <Path path="177" as="178" dim="127" />
-          <Path path="741" as="180" dim="181" />
+          <Path path="733" as="180" dim="181" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_skn" name="PARAM_K_Water_INT_skn" formula="K_water_int">
         <Paths>
-          <Path path="742" as="193" />
+          <Path path="734" as="193" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_skn" name="PARAM_K_Water_CELL_skn" formula="K_water_cell">
         <Paths>
-          <Path path="743" as="197" />
+          <Path path="735" as="197" />
         </Paths>
       </Formula>
       <Formula id="CompartmentsVolume_2Poren.VOLUME_end_skn" name="VOLUME_end_skn" dim="Volume" formula="f_endo*SA_pls_int*d_endo">
         <Paths>
           <Path path="199" as="200" dim="24" />
           <Path path="177" as="178" dim="127" />
-          <Path path="741" as="180" dim="181" />
+          <Path path="733" as="180" dim="181" />
         </Paths>
       </Formula>
       <Formula id="VascularEndoVolume.VOLUME_VascularEndo_spl" name="VOLUME_VascularEndo_spl" dim="Volume" formula="SA_pls_int*d_endo">
         <Paths>
           <Path path="177" as="178" dim="127" />
-          <Path path="744" as="180" dim="181" />
+          <Path path="736" as="180" dim="181" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_spl" name="PARAM_K_Water_INT_spl" formula="K_water_int">
         <Paths>
-          <Path path="745" as="193" />
+          <Path path="737" as="193" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_spl" name="PARAM_K_Water_CELL_spl" formula="K_water_cell">
         <Paths>
-          <Path path="746" as="197" />
+          <Path path="738" as="197" />
         </Paths>
       </Formula>
       <Formula id="CompartmentsVolume_2Poren.VOLUME_end_spl" name="VOLUME_end_spl" dim="Volume" formula="f_endo*SA_pls_int*d_endo">
         <Paths>
           <Path path="199" as="200" dim="24" />
           <Path path="177" as="178" dim="127" />
-          <Path path="744" as="180" dim="181" />
+          <Path path="736" as="180" dim="181" />
         </Paths>
       </Formula>
-      <Formula id="EndosomalSpaceBindingFormulas.PARAM_krpls" name="PARAM_krpls" dim="Flow" formula="f_mem_pls* f_uptake_vas * K_uptake * V_end">
+      <Formula id="EndosomalSpaceBindingFormulas.PARAM_F_Mem_INT" name="PARAM_F_Mem_INT" formula="Volume_EndogenIgG_int / Volume_EndogenIgG_endosom">
         <Paths>
-          <Path path="747" as="748" />
-          <Path path="749" as="750" dim="24" />
-          <Path path="751" as="110" dim="111" />
-          <Path path="752" as="753" dim="50" />
+          <Path path="739" as="740" dim="55" />
+          <Path path="741" as="742" dim="55" />
         </Paths>
       </Formula>
-      <Formula id="EndosomalSpaceBindingFormulas.PARAM_krint" name="PARAM_krint" dim="Flow" formula="f_mem_int* (1- f_uptake_vas)* K_uptake * V_end">
+      <Formula id="EndosomalSpaceBindingFormulas.PARAM_F_Mem_PLS" name="PARAM_F_Mem_PLS" formula="Volume_EndogenIgG_pls / Volume_EndogenIgG_endosom">
         <Paths>
-          <Path path="754" as="755" />
-          <Path path="749" as="750" dim="24" />
-          <Path path="751" as="110" dim="111" />
-          <Path path="752" as="753" dim="50" />
+          <Path path="739" as="740" dim="55" />
+          <Path path="743" as="744" dim="55" />
         </Paths>
       </Formula>
-      <Formula id="EndosomalSpaceBindingFormulas.PARAM_F_Mem_PLS" name="PARAM_F_Mem_PLS" formula="Volume_EndogenIgG_pls / Volume_EndogenIgG_endosom">
+      <Formula id="EndosomalSpaceBindingFormulas.PARAM_krint" name="PARAM_krint" dim="Flow" formula="f_mem_int* (1- f_uptake_vas)* K_uptake * V_end">
         <Paths>
-          <Path path="752" as="756" dim="50" />
-          <Path path="757" as="758" dim="50" />
+          <Path path="745" as="746" dim="24" />
+          <Path path="747" as="49" dim="50" />
+          <Path path="748" as="749" />
+          <Path path="739" as="750" dim="55" />
         </Paths>
       </Formula>
-      <Formula id="EndosomalSpaceBindingFormulas.PARAM_F_Mem_INT" name="PARAM_F_Mem_INT" formula="Volume_EndogenIgG_int / Volume_EndogenIgG_endosom">
+      <Formula id="EndosomalSpaceBindingFormulas.PARAM_krpls" name="PARAM_krpls" dim="Flow" formula="f_mem_pls* f_uptake_vas * K_uptake * V_end">
         <Paths>
-          <Path path="752" as="756" dim="50" />
-          <Path path="759" as="760" dim="50" />
+          <Path path="745" as="746" dim="24" />
+          <Path path="747" as="49" dim="50" />
+          <Path path="751" as="752" />
+          <Path path="739" as="750" dim="55" />
         </Paths>
       </Formula>
-      <Formula id="TwoPoresGammaSigma.PARAM_sigma_s_Endogenous_Igg" name="PARAM_sigma_s_Endogenous_Igg" formula="gamma&lt;1 ? 1-(1-gamma)^2*(2-(1-gamma)^2)*(1-gamma/3)/(1-gamma/3+2/3*gamma^2) : 0.999">
+      <Formula id="EndosomalSpaceBindingFormulas.PARAM_igg_k_conv" name="PARAM_igg_k_conv" dim="Flow" formula="(J_iso + alpha_l*Q_lymph)*(1-sigma_l) + (-J_iso+(1-alpha_l)*Q_lymph)*(1-sigma_s)">
         <Paths>
-          <Path path="761" as="762" />
+          <Path path="162" as="163" />
+          <Path path="753" as="667" dim="168" />
+          <Path path="166" as="167" dim="168" />
+          <Path path="754" as="755" />
+          <Path path="756" as="757" />
         </Paths>
       </Formula>
-      <Formula id="TwoPoresGammaSigma.PARAM_sigma_l_Endogenous_Igg" name="PARAM_sigma_l_Endogenous_Igg" formula="gamma&lt;1 ? 1-(1-gamma)^2*(2-(1-gamma)^2)*(1-gamma/3)/(1-gamma/3+2/3*gamma^2) : 0.999">
+      <Formula id="EndosomalSpaceBindingFormulas.PARAM_igg_k_diff_int" name="PARAM_igg_k_diff_int" dim="Flow" formula="k_diff_pls">
         <Paths>
-          <Path path="763" as="762" />
+          <Path path="758" as="759" dim="168" />
         </Paths>
       </Formula>
-      <Formula id="TwoPoresGammaSigma.PARAM_gamma_s_Endogenous_Igg" name="PARAM_gamma_s_Endogenous_Igg" formula="a_e_endog / r_s">
+      <Formula id="EndosomalSpaceBindingFormulas.PARAM_igg_k_diff_pls" name="PARAM_igg_k_diff_pls" dim="Flow" formula="P_endothelial_l*SA_pls_int*Pe_l/(exp(Pe_l)-1) + P_endothelial_s*SA_pls_int*Pe_s/(exp(Pe_s)-1)">
         <Paths>
-          <Path path="764" as="765" dim="127" />
-          <Path path="766" as="767" dim="127" />
+          <Path path="760" as="761" dim="2" />
+          <Path path="762" as="763" dim="2" />
+          <Path path="764" as="765" />
+          <Path path="766" as="767" />
+          <Path path="768" as="180" dim="181" />
         </Paths>
       </Formula>
-      <Formula id="DiffusionPlasma_2Poren.PARAM_P_endothelial_l_Endogenous_Igg" name="PARAM_P_endothelial_l_Endogenous_Igg" dim="Velocity" formula="gamma&lt;1 ? (1-gamma)^4.5/(1-0.3956*gamma+1.0616*gamma^2)* alpha_l*8*Lp/(r)^2 * RT/(6*Pi*Na*a_e_endog) : 1e-22">
+      <Formula id="EndosomalSpaceBindingFormulas.PARAM_igg_kdeg" name="PARAM_igg_kdeg" dim="Flow" formula="CLspec*V_end">
         <Paths>
-          <Path path="162" as="163" />
-          <Path path="768" as="769" dim="660" />
-          <Path path="770" as="771" dim="127" />
-          <Path path="763" as="762" />
-          <Path path="772" as="773" dim="774" />
-          <Path path="775" as="776" dim="776" />
-          <Path path="766" as="767" dim="127" />
+          <Path path="769" as="770" dim="50" />
+          <Path path="739" as="750" dim="55" />
         </Paths>
       </Formula>
-      <Formula id="EndosomalSpaceBindingFormulas.PARAM_igg_kpe" name="PARAM_igg_kpe" dim="Flow" formula="f_uptake_vas*K_uptake*V_end">
+      <Formula id="EndosomalSpaceBindingFormulas.PARAM_igg_kei" name="PARAM_igg_kei" dim="Flow" formula="(1-f_rec_vas)*K_rec*V_end">
         <Paths>
-          <Path path="749" as="750" dim="24" />
-          <Path path="751" as="110" dim="111" />
-          <Path path="752" as="753" dim="50" />
+          <Path path="771" as="772" dim="24" />
+          <Path path="773" as="52" dim="50" />
+          <Path path="739" as="750" dim="55" />
         </Paths>
       </Formula>
-      <Formula id="EndosomalSpaceBindingFormulas.PARAM_igg_k_diff_int" name="PARAM_igg_k_diff_int" dim="Flow" formula="k_diff_pls">
+      <Formula id="EndosomalSpaceBindingFormulas.PARAM_igg_kep" name="PARAM_igg_kep" dim="Flow" formula="f_rec_vas*K_rec*V_end">
         <Paths>
-          <Path path="777" as="778" dim="168" />
+          <Path path="771" as="772" dim="24" />
+          <Path path="773" as="52" dim="50" />
+          <Path path="739" as="750" dim="55" />
         </Paths>
       </Formula>
       <Formula id="EndosomalSpaceBindingFormulas.PARAM_igg_kie" name="PARAM_igg_kie" dim="Flow" formula="(1-f_uptake_vas)*K_uptake*V_end">
         <Paths>
-          <Path path="749" as="750" dim="24" />
-          <Path path="751" as="110" dim="111" />
-          <Path path="752" as="753" dim="50" />
+          <Path path="745" as="746" dim="24" />
+          <Path path="747" as="49" dim="50" />
+          <Path path="739" as="750" dim="55" />
         </Paths>
       </Formula>
-      <Formula id="EndosomalSpaceBindingFormulas.PARAM_igg_kep" name="PARAM_igg_kep" dim="Flow" formula="f_rec_vas*K_rec*V_end">
+      <Formula id="EndosomalSpaceBindingFormulas.PARAM_igg_kin" name="PARAM_igg_kin" dim="Amount per time" formula="Cpl*kdeg*(k_diff_pls*kei*kie+k_diff_pls*Kd*ka*Ve*kie+k_diff_pls*kep*kie+k_conv*kei*kie+k_conv*Kd*ka*Ve*kie+k_conv*kep*kie+kpe*kep*kie+kpe*kep*k_diff_int+kpe*kep*Ql+kpe*Kd*ka*Ve*Ql+kpe*kei*k_diff_int+kpe*kei*Ql+kpe*Kd*ka*Ve*kie+kpe*Kd*ka*Ve*k_diff_int+kpe*kei*kie)/(kdeg*kep*Ql+kdeg*kep*kie+kdeg*kep*k_diff_int+ka*FcRnEnd*Ve*kei*Ql+ka*FcRnEnd*Ve*kei*k_diff_int+ka*FcRnEnd*Ve*kep*Ql+ka*FcRnEnd*Ve*kep*kie+ka*FcRnEnd*Ve*kep*k_diff_int+kdeg*Kd*ka*Ve*Ql+kdeg*Kd*ka*Ve*kie+kdeg*Kd*ka*Ve*k_diff_int+kdeg*kei*Ql+kdeg*kei*kie+kdeg*kei*k_diff_int)">
         <Paths>
-          <Path path="779" as="780" dim="24" />
-          <Path path="781" as="113" dim="111" />
-          <Path path="752" as="753" dim="50" />
+          <Path path="774" as="775" dim="168" />
+          <Path path="776" as="777" dim="168" />
+          <Path path="778" as="779" dim="168" />
+          <Path path="780" as="781" dim="168" />
+          <Path path="782" as="783" dim="168" />
+          <Path path="784" as="785" dim="141" />
+          <Path path="166" as="786" dim="168" />
+          <Path path="787" as="788" dim="168" />
+          <Path path="789" as="790" dim="168" />
+          <Path path="758" as="759" dim="168" />
+          <Path path="791" as="792" dim="793" />
+          <Path path="794" as="795" dim="55" />
+          <Path path="796" as="797" dim="141" />
+          <Path path="798" as="799" dim="141" />
         </Paths>
       </Formula>
-      <Formula id="EndosomalSpaceBindingFormulas.PARAM_igg_kei" name="PARAM_igg_kei" dim="Flow" formula="(1-f_rec_vas)*K_rec*V_end">
+      <Formula id="EndosomalSpaceBindingFormulas.PARAM_igg_kpe" name="PARAM_igg_kpe" dim="Flow" formula="f_uptake_vas*K_uptake*V_end">
         <Paths>
-          <Path path="779" as="780" dim="24" />
-          <Path path="781" as="113" dim="111" />
-          <Path path="752" as="753" dim="50" />
+          <Path path="745" as="746" dim="24" />
+          <Path path="747" as="49" dim="50" />
+          <Path path="739" as="750" dim="55" />
         </Paths>
       </Formula>
-      <Formula id="EndosomalSpaceBindingFormulas.PARAM_igg_kdeg" name="PARAM_igg_kdeg" dim="Flow" formula="CLspec*V_end">
+      <Formula id="DiffusionPlasma_2Poren.PARAM_P_endothelial_l_Endogenous_Igg" name="PARAM_P_endothelial_l_Endogenous_Igg" dim="Velocity" formula="gamma&lt;1 ? (1-gamma)^4.5/(1-0.3956*gamma+1.0616*gamma^2)* alpha_l*8*Lp/(r)^2 * RT/(6*Pi*Na*a_e_endog) : 1e-22">
         <Paths>
-          <Path path="782" as="783" dim="111" />
-          <Path path="752" as="753" dim="50" />
+          <Path path="162" as="163" />
+          <Path path="800" as="801" dim="669" />
+          <Path path="802" as="803" dim="127" />
+          <Path path="804" as="805" />
+          <Path path="806" as="807" dim="808" />
+          <Path path="809" as="810" dim="810" />
+          <Path path="811" as="812" dim="127" />
         </Paths>
       </Formula>
-      <Formula id="EndosomalSpaceBindingFormulas.PARAM_igg_kin" name="PARAM_igg_kin" dim="Amount per time" formula="Cpl*kdeg*(k_diff_pls*kei*kie+k_diff_pls*Kd*ka*Ve*kie+k_diff_pls*kep*kie+k_conv*kei*kie+k_conv*Kd*ka*Ve*kie+k_conv*kep*kie+kpe*kep*kie+kpe*kep*k_diff_int+kpe*kep*Ql+kpe*Kd*ka*Ve*Ql+kpe*kei*k_diff_int+kpe*kei*Ql+kpe*Kd*ka*Ve*kie+kpe*Kd*ka*Ve*k_diff_int+kpe*kei*kie)/(kdeg*kep*Ql+kdeg*kep*kie+kdeg*kep*k_diff_int+ka*FcRnEnd*Ve*kei*Ql+ka*FcRnEnd*Ve*kei*k_diff_int+ka*FcRnEnd*Ve*kep*Ql+ka*FcRnEnd*Ve*kep*kie+ka*FcRnEnd*Ve*kep*k_diff_int+kdeg*Kd*ka*Ve*Ql+kdeg*Kd*ka*Ve*kie+kdeg*Kd*ka*Ve*k_diff_int+kdeg*kei*Ql+kdeg*kei*kie+kdeg*kei*k_diff_int)">
+      <Formula id="DiffusionPlasma_2Poren.PARAM_P_endothelial_s_Endogenous_Igg" name="PARAM_P_endothelial_s_Endogenous_Igg" dim="Velocity" formula="gamma&lt;1 ? (1-gamma)^4.5/(1-0.3956*gamma+1.0616*gamma^2)* (1-alpha_l)*8*Lp/(r)^2 * RT/(6*Pi*Na*a_e_endog) : 1e-22">
         <Paths>
-          <Path path="784" as="785" dim="168" />
-          <Path path="786" as="787" dim="168" />
-          <Path path="777" as="778" dim="168" />
-          <Path path="788" as="789" dim="168" />
-          <Path path="790" as="791" dim="168" />
-          <Path path="792" as="793" dim="168" />
-          <Path path="794" as="795" dim="168" />
-          <Path path="796" as="797" dim="168" />
-          <Path path="798" as="799" dim="800" />
-          <Path path="801" as="802" dim="141" />
-          <Path path="166" as="803" dim="168" />
-          <Path path="804" as="805" dim="50" />
-          <Path path="806" as="807" dim="141" />
-          <Path path="808" as="809" dim="141" />
+          <Path path="162" as="163" />
+          <Path path="800" as="801" dim="669" />
+          <Path path="813" as="803" dim="127" />
+          <Path path="814" as="805" />
+          <Path path="806" as="807" dim="808" />
+          <Path path="809" as="810" dim="810" />
+          <Path path="811" as="812" dim="127" />
         </Paths>
       </Formula>
-      <Formula id="CalcPecletNumber.PecletNumber_s_Endogenous_Igg" name="PecletNumber_s_Endogenous_Igg" formula="(-J_iso+(1-alpha_l)*Q_lymph)*(1-sigma_s)/(P_endothelial_s*SA_pls_int)">
+      <Formula id="CalcPecletNumber.PecletNumber_l_Endogenous_Igg" name="PecletNumber_l_Endogenous_Igg" formula="(J_iso+alpha_l*Q_lymph)*(1-sigma_l)/(P_endothelial_l*SA_pls_int)">
         <Paths>
           <Path path="162" as="163" />
-          <Path path="810" as="662" dim="168" />
+          <Path path="753" as="667" dim="168" />
           <Path path="166" as="167" dim="168" />
-          <Path path="811" as="812" dim="2" />
-          <Path path="813" as="814" />
-          <Path path="815" as="180" dim="181" />
-        </Paths>
-      </Formula>
-      <Formula id="TwoPoresGammaSigma.PARAM_gamma_l_Endogenous_Igg" name="PARAM_gamma_l_Endogenous_Igg" formula="a_e_endog / r_l">
-        <Paths>
-          <Path path="770" as="816" dim="127" />
-          <Path path="766" as="767" dim="127" />
+          <Path path="760" as="761" dim="2" />
+          <Path path="754" as="755" />
+          <Path path="768" as="180" dim="181" />
         </Paths>
       </Formula>
-      <Formula id="CalcPecletNumber.PecletNumber_l_Endogenous_Igg" name="PecletNumber_l_Endogenous_Igg" formula="(J_iso+alpha_l*Q_lymph)*(1-sigma_l)/(P_endothelial_l*SA_pls_int)">
+      <Formula id="CalcPecletNumber.PecletNumber_s_Endogenous_Igg" name="PecletNumber_s_Endogenous_Igg" formula="(-J_iso+(1-alpha_l)*Q_lymph)*(1-sigma_s)/(P_endothelial_s*SA_pls_int)">
         <Paths>
           <Path path="162" as="163" />
-          <Path path="810" as="662" dim="168" />
+          <Path path="753" as="667" dim="168" />
           <Path path="166" as="167" dim="168" />
-          <Path path="817" as="818" dim="2" />
-          <Path path="819" as="820" />
-          <Path path="815" as="180" dim="181" />
+          <Path path="762" as="763" dim="2" />
+          <Path path="756" as="757" />
+          <Path path="768" as="180" dim="181" />
         </Paths>
       </Formula>
-      <Formula id="DiffusionPlasma_2Poren.PARAM_P_endothelial_s_Endogenous_Igg" name="PARAM_P_endothelial_s_Endogenous_Igg" dim="Velocity" formula="gamma&lt;1 ? (1-gamma)^4.5/(1-0.3956*gamma+1.0616*gamma^2)* (1-alpha_l)*8*Lp/(r)^2 * RT/(6*Pi*Na*a_e_endog) : 1e-22">
+      <Formula id="TwoPoresGammaSigma.PARAM_gamma_l_Endogenous_Igg" name="PARAM_gamma_l_Endogenous_Igg" formula="a_e_endog / r_l">
         <Paths>
-          <Path path="162" as="163" />
-          <Path path="768" as="769" dim="660" />
-          <Path path="764" as="771" dim="127" />
-          <Path path="761" as="762" />
-          <Path path="772" as="773" dim="774" />
-          <Path path="775" as="776" dim="776" />
-          <Path path="766" as="767" dim="127" />
+          <Path path="802" as="815" dim="127" />
+          <Path path="811" as="812" dim="127" />
         </Paths>
       </Formula>
-      <Formula id="EndosomalSpaceBindingFormulas.PARAM_igg_k_diff_pls" name="PARAM_igg_k_diff_pls" dim="Flow" formula="P_endothelial_l*SA_pls_int*Pe_l/(exp(Pe_l)-1) + P_endothelial_s*SA_pls_int*Pe_s/(exp(Pe_s)-1)">
+      <Formula id="TwoPoresGammaSigma.PARAM_gamma_s_Endogenous_Igg" name="PARAM_gamma_s_Endogenous_Igg" formula="a_e_endog / r_s">
         <Paths>
-          <Path path="817" as="818" dim="2" />
-          <Path path="811" as="812" dim="2" />
-          <Path path="821" as="822" />
-          <Path path="823" as="824" />
-          <Path path="815" as="180" dim="181" />
+          <Path path="813" as="816" dim="127" />
+          <Path path="811" as="812" dim="127" />
         </Paths>
       </Formula>
-      <Formula id="EndosomalSpaceBindingFormulas.PARAM_igg_k_conv" name="PARAM_igg_k_conv" dim="Flow" formula="(J_iso + alpha_l*Q_lymph)*(1-sigma_l) + (-J_iso+(1-alpha_l)*Q_lymph)*(1-sigma_s)">
+      <Formula id="TwoPoresGammaSigma.PARAM_sigma_l_Endogenous_Igg" name="PARAM_sigma_l_Endogenous_Igg" formula="gamma&lt;1 ? 1-(1-gamma)^2*(2-(1-gamma)^2)*(1-gamma/3)/(1-gamma/3+2/3*gamma^2) : 0.999">
         <Paths>
-          <Path path="162" as="163" />
-          <Path path="810" as="662" dim="168" />
-          <Path path="166" as="167" dim="168" />
-          <Path path="819" as="820" />
-          <Path path="813" as="814" />
+          <Path path="804" as="805" />
         </Paths>
       </Formula>
-      <Formula id="VascularEndoVolume.VOLUME_VascularEndo_igg" name="VOLUME_VascularEndo_igg" dim="Volume" formula="SA_pls_int*d_endo">
+      <Formula id="TwoPoresGammaSigma.PARAM_sigma_s_Endogenous_Igg" name="PARAM_sigma_s_Endogenous_Igg" formula="gamma&lt;1 ? 1-(1-gamma)^2*(2-(1-gamma)^2)*(1-gamma/3)/(1-gamma/3+2/3*gamma^2) : 0.999">
         <Paths>
-          <Path path="177" as="178" dim="127" />
-          <Path path="815" as="180" dim="181" />
+          <Path path="814" as="805" />
         </Paths>
       </Formula>
       <Formula id="Individual_PKSim.PARAM_igg_J_iso" name="PARAM_igg_J_iso" dim="Flow" formula="J_iso_bon+J_iso_brn+J_iso_fat+J_iso_tes+J_iso_hrt+J_iso_kid+J_iso_lin+J_iso_liv+J_iso_lng+J_iso_mus+J_iso_pan+J_iso_skn+J_iso_sin+J_iso_spl+J_iso_sto">
         <Paths>
+          <Path path="817" as="818" dim="168" />
+          <Path path="819" as="820" dim="168" />
+          <Path path="821" as="822" dim="168" />
+          <Path path="823" as="824" dim="168" />
           <Path path="825" as="826" dim="168" />
           <Path path="827" as="828" dim="168" />
           <Path path="829" as="830" dim="168" />
@@ -25527,134 +25600,136 @@
           <Path path="841" as="842" dim="168" />
           <Path path="843" as="844" dim="168" />
           <Path path="845" as="846" dim="168" />
+        </Paths>
+      </Formula>
+      <Formula id="Individual_PKSim.PARAM_Q_lymph_igg" name="PARAM_Q_lymph_igg" dim="Flow" formula="Q_lymph_bon+Q_lymph_brn+Q_lymph_fat+Q_lymph_tes+Q_lymph_hrt+Q_lymph_kid+Q_lymph_lin+Q_lymph_liv+Q_lymph_lng+Q_lymph_mus+Q_lymph_pan+Q_lymph_skn+Q_lymph_sin+Q_lymph_spl+Q_lymph_sto">
+        <Paths>
           <Path path="847" as="848" dim="168" />
           <Path path="849" as="850" dim="168" />
           <Path path="851" as="852" dim="168" />
           <Path path="853" as="854" dim="168" />
+          <Path path="855" as="856" dim="168" />
+          <Path path="857" as="858" dim="168" />
+          <Path path="713" as="859" dim="168" />
+          <Path path="860" as="861" dim="168" />
+          <Path path="862" as="863" dim="168" />
+          <Path path="864" as="865" dim="168" />
+          <Path path="715" as="866" dim="168" />
+          <Path path="867" as="868" dim="168" />
+          <Path path="717" as="869" dim="168" />
+          <Path path="719" as="870" dim="168" />
+          <Path path="721" as="871" dim="168" />
         </Paths>
       </Formula>
-      <Formula id="Individual_PKSim.PARAM_Q_lymph_igg" name="PARAM_Q_lymph_igg" dim="Flow" formula="Q_lymph_bon+Q_lymph_brn+Q_lymph_fat+Q_lymph_tes+Q_lymph_hrt+Q_lymph_kid+Q_lymph_lin+Q_lymph_liv+Q_lymph_lng+Q_lymph_mus+Q_lymph_pan+Q_lymph_skn+Q_lymph_sin+Q_lymph_spl+Q_lymph_sto">
+      <Formula id="VascularEndoVolume.VOLUME_VascularEndo_igg" name="VOLUME_VascularEndo_igg" dim="Volume" formula="SA_pls_int*d_endo">
         <Paths>
-          <Path path="855" as="856" dim="168" />
-          <Path path="857" as="858" dim="168" />
-          <Path path="859" as="860" dim="168" />
-          <Path path="861" as="862" dim="168" />
-          <Path path="863" as="864" dim="168" />
-          <Path path="865" as="866" dim="168" />
-          <Path path="731" as="867" dim="168" />
-          <Path path="868" as="869" dim="168" />
-          <Path path="870" as="871" dim="168" />
-          <Path path="872" as="873" dim="168" />
-          <Path path="733" as="874" dim="168" />
-          <Path path="875" as="876" dim="168" />
-          <Path path="735" as="877" dim="168" />
-          <Path path="737" as="878" dim="168" />
-          <Path path="739" as="879" dim="168" />
+          <Path path="177" as="178" dim="127" />
+          <Path path="768" as="180" dim="181" />
         </Paths>
       </Formula>
       <Formula id="EndosomalSpaceBindingFormulas.KdFcRn_LigandEndo_in_Container_Plasma_and_Interstitial" name="KdFcRn_LigandEndo_in_Container_Plasma_and_Interstitial" dim="Concentration (molar)" formula="Kd_FcRn_LigandEndo">
         <Paths>
-          <Path path="880" as="881" dim="141" />
+          <Path path="872" as="873" dim="141" />
         </Paths>
       </Formula>
       <Formula id="CompartmentsVolume_2Poren.VOLUME_pls_ecl" name="VOLUME_pls_ecl" dim="Volume" formula="V_bon+V_brn+V_fat+V_tes+V_hrt+V_kid+V_lin+V_liv+V_lng+V_mus+V_pan+V_skn+V_sin+V_spl+V_sto+V_duo+V_uje+V_lje+V_uil+V_lil+V_cae+V_colasc+V_coltrans+V_coldesc+V_colsigm+V_rect">
         <Paths>
-          <Path path="93" as="574" dim="50" />
-          <Path path="95" as="882" dim="50" />
-          <Path path="99" as="883" dim="50" />
-          <Path path="101" as="884" dim="50" />
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-          <Path path="73" as="898" dim="50" />
-          <Path path="75" as="899" dim="50" />
-          <Path path="77" as="900" dim="50" />
-          <Path path="79" as="901" dim="50" />
+          <Path path="98" as="588" dim="55" />
+          <Path path="100" as="874" dim="55" />
+          <Path path="104" as="875" dim="55" />
+          <Path path="106" as="876" dim="55" />
+          <Path path="102" as="877" dim="55" />
+          <Path path="88" as="535" dim="55" />
+          <Path path="96" as="537" dim="55" />
+          <Path path="92" as="539" dim="55" />
+          <Path path="108" as="878" dim="55" />
+          <Path path="94" as="541" dim="55" />
+          <Path path="90" as="543" dim="55" />
+          <Path path="56" as="879" dim="55" />
+          <Path path="58" as="880" dim="55" />
+          <Path path="60" as="881" dim="55" />
+          <Path path="62" as="882" dim="55" />
+          <Path path="64" as="883" dim="55" />
+          <Path path="66" as="884" dim="55" />
+          <Path path="68" as="885" dim="55" />
+          <Path path="886" as="664" dim="55" />
+          <Path path="70" as="887" dim="55" />
+          <Path path="72" as="888" dim="55" />
+          <Path path="74" as="889" dim="55" />
+          <Path path="78" as="890" dim="55" />
+          <Path path="80" as="891" dim="55" />
+          <Path path="82" as="892" dim="55" />
+          <Path path="84" as="893" dim="55" />
         </Paths>
       </Formula>
       <Formula id="CompartmentsVolume_2Poren.VOLUME_int_ecl" name="VOLUME_int_ecl" dim="Volume" formula="V_bon+V_brn+V_fat+V_tes+V_hrt+V_kid+V_lin+V_liv+V_lng+V_mus+V_pan+V_skn+V_sin+V_spl+V_sto+V_duo+V_uje+V_lje+V_uil+V_lil+V_cae+V_colasc+V_coltrans+V_coldesc+V_colsigm+V_rect">
         <Paths>
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-          <Path path="903" as="882" dim="50" />
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-          <Path path="906" as="885" dim="50" />
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-          <Path path="924" as="898" dim="50" />
-          <Path path="925" as="899" dim="50" />
-          <Path path="926" as="900" dim="50" />
-          <Path path="927" as="901" dim="50" />
+          <Path path="894" as="588" dim="55" />
+          <Path path="895" as="874" dim="55" />
+          <Path path="896" as="875" dim="55" />
+          <Path path="897" as="876" dim="55" />
+          <Path path="898" as="877" dim="55" />
+          <Path path="899" as="535" dim="55" />
+          <Path path="900" as="537" dim="55" />
+          <Path path="901" as="539" dim="55" />
+          <Path path="902" as="878" dim="55" />
+          <Path path="903" as="541" dim="55" />
+          <Path path="904" as="543" dim="55" />
+          <Path path="905" as="879" dim="55" />
+          <Path path="906" as="880" dim="55" />
+          <Path path="907" as="881" dim="55" />
+          <Path path="908" as="882" dim="55" />
+          <Path path="909" as="883" dim="55" />
+          <Path path="910" as="884" dim="55" />
+          <Path path="911" as="885" dim="55" />
+          <Path path="912" as="664" dim="55" />
+          <Path path="913" as="887" dim="55" />
+          <Path path="914" as="888" dim="55" />
+          <Path path="915" as="889" dim="55" />
+          <Path path="916" as="890" dim="55" />
+          <Path path="917" as="891" dim="55" />
+          <Path path="918" as="892" dim="55" />
+          <Path path="919" as="893" dim="55" />
         </Paths>
       </Formula>
       <Formula id="EndosomalSpaceBindingFormulas.KdFcRn_LigandEndo_in_Container_Endosomal" name="KdFcRn_LigandEndo_in_Container_Endosomal" dim="Concentration (molar)" formula="Kd_FcRn_LigandEndo">
         <Paths>
-          <Path path="928" as="881" dim="141" />
+          <Path path="920" as="873" dim="141" />
         </Paths>
       </Formula>
       <Formula id="SpecificClearance_PKSim.PARAM_CLSpec_endosomal" name="PARAM_CLSpec_endosomal" dim="Inversed time" formula="CLspec_endosomal_global">
         <Paths>
-          <Path path="929" as="930" dim="111" />
+          <Path path="921" as="922" dim="50" />
         </Paths>
       </Formula>
       <Formula id="CompartmentsVolume_2Poren.VOLUME_end_ecl" name="VOLUME_end_ecl" dim="Volume" formula="V_bon+V_brn+V_fat+V_tes+V_hrt+V_kid+V_lin+V_liv+V_lng+V_mus+V_pan+V_skn+V_sin+V_spl+V_sto+V_duo+V_uje+V_lje+V_uil+V_lil+V_cae+V_colasc+V_coltrans+V_coldesc+V_colsigm+V_rect">
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-          <Path path="932" as="882" dim="50" />
-          <Path path="933" as="883" dim="50" />
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-          <Path path="953" as="898" dim="50" />
-          <Path path="954" as="899" dim="50" />
-          <Path path="955" as="900" dim="50" />
-          <Path path="956" as="901" dim="50" />
+          <Path path="923" as="588" dim="55" />
+          <Path path="924" as="874" dim="55" />
+          <Path path="925" as="875" dim="55" />
+          <Path path="926" as="876" dim="55" />
+          <Path path="927" as="877" dim="55" />
+          <Path path="928" as="535" dim="55" />
+          <Path path="929" as="537" dim="55" />
+          <Path path="930" as="539" dim="55" />
+          <Path path="931" as="878" dim="55" />
+          <Path path="932" as="541" dim="55" />
+          <Path path="933" as="543" dim="55" />
+          <Path path="934" as="879" dim="55" />
+          <Path path="935" as="880" dim="55" />
+          <Path path="936" as="881" dim="55" />
+          <Path path="937" as="882" dim="55" />
+          <Path path="938" as="883" dim="55" />
+          <Path path="939" as="884" dim="55" />
+          <Path path="940" as="885" dim="55" />
+          <Path path="941" as="664" dim="55" />
+          <Path path="942" as="887" dim="55" />
+          <Path path="943" as="888" dim="55" />
+          <Path path="944" as="889" dim="55" />
+          <Path path="945" as="890" dim="55" />
+          <Path path="946" as="891" dim="55" />
+          <Path path="947" as="892" dim="55" />
+          <Path path="948" as="893" dim="55" />
         </Paths>
       </Formula>
       <Formula id="Individual_PKSim.VOLUME_Saliva_Organ" name="VOLUME_Saliva_Organ" dim="Volume" formula="0.006 * BW / 73">
@@ -25664,162 +25739,175 @@
       </Formula>
       <Formula id="CompartmentsVolume_2Poren.VOLUME_slv_slv" name="VOLUME_slv_slv" dim="Volume" formula="V_slv">
         <Paths>
-          <Path path="957" as="958" dim="50" />
+          <Path path="949" as="950" dim="55" />
         </Paths>
       </Formula>
       <Formula id="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls_Blood_Organ" name="PARAM_SA_rbc_pls_Blood_Organ" dim="Area" formula="HCT * A_to_V_bc * 0.6 * V">
         <Paths>
-          <Path path="959" as="138" dim="50" />
+          <Path path="951" as="138" dim="55" />
           <Path path="40" as="41" />
-          <Path path="960" as="961" dim="356" />
+          <Path path="952" as="953" dim="384" />
         </Paths>
       </Formula>
-      <Formula id="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" name="PARAM_SA_rbc_pls" dim="Area" formula="HCT * A_to_V_bc * 0.6 * V * f_vas">
+      <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_bon" name="PARAM_SA_int_cell_bon" dim="Area" formula="(V_bon * 1000 / 28.2)^0.75 * 10 * 1E2">
         <Paths>
-          <Path path="962" as="136" />
-          <Path path="959" as="138" dim="50" />
-          <Path path="40" as="41" />
-          <Path path="960" as="961" dim="356" />
+          <Path path="951" as="879" dim="55" />
         </Paths>
       </Formula>
-      <Formula id="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" name="PARAM_SA_pls_int" dim="Area" formula="k * f_vas_org * V_org">
+      <Formula id="DiffusionCommon_PKSim.PARAM_P_int_cell" name="PARAM_P_int_cell" dim="Velocity" formula="P * P_int_cell_factor">
         <Paths>
-          <Path path="962" as="963" />
-          <Path path="959" as="187" dim="50" />
-          <Path path="964" as="360" dim="356" />
+          <Path path="954" as="955" />
+          <Path path="14" as="15" dim="2" />
         </Paths>
       </Formula>
-      <Formula id="DiffusionPlasma_2Poren.PARAM_P_endothelial_s" name="PARAM_P_endothelial_s" dim="Velocity" formula="gamma&lt;1 ? (1-gamma)^4.5/(1-0.3956*gamma+1.0616*gamma^2)* (1-alpha_l)*8*Lp/(r)^2 * RT/(6*Pi*Na*a_e) : 1e-22">
+      <Formula id="DiffusionCommon_PKSim.PARAM_P_cell_int" name="PARAM_P_cell_int" dim="Velocity" formula="P * P_cell_int_factor">
         <Paths>
-          <Path path="761" as="762" />
-          <Path path="965" as="966" dim="127" />
-          <Path path="967" as="163" />
-          <Path path="968" as="769" dim="660" />
-          <Path path="969" as="771" dim="127" />
-          <Path path="772" as="773" dim="774" />
-          <Path path="775" as="776" dim="776" />
+          <Path path="956" as="957" />
+          <Path path="14" as="15" dim="2" />
         </Paths>
       </Formula>
-      <Formula id="DiffusionPlasma_2Poren.PARAM_P_endothelial" name="PARAM_P_endothelial" dim="Velocity" formula="P/2">
+      <Formula id="DiffusionCommon_PKSim.PARAM_PA_int_cell" name="PARAM_PA_int_cell" dim="Flow" formula="P_int_cell * SA">
         <Paths>
-          <Path path="7" as="8" dim="2" />
+          <Path path="958" as="959" dim="2" />
+          <Path path="960" as="961" dim="181" />
         </Paths>
       </Formula>
-      <Formula id="DiffusionPlasma_2Poren.PARAM_P_endothelial_l" name="PARAM_P_endothelial_l" dim="Velocity" formula="gamma&lt;1 ? (1-gamma)^4.5/(1-0.3956*gamma+1.0616*gamma^2)* alpha_l*8*Lp/(r)^2 * RT/(6*Pi*Na*a_e) : 1e-22">
+      <Formula id="DiffusionCommon_PKSim.PARAM_PA_cell_int" name="PARAM_PA_cell_int" dim="Flow" formula="P_cell_int * SA">
         <Paths>
-          <Path path="763" as="762" />
-          <Path path="965" as="966" dim="127" />
-          <Path path="967" as="163" />
-          <Path path="968" as="769" dim="660" />
-          <Path path="970" as="771" dim="127" />
-          <Path path="772" as="773" dim="774" />
-          <Path path="775" as="776" dim="776" />
+          <Path path="962" as="963" dim="2" />
+          <Path path="960" as="961" dim="181" />
         </Paths>
       </Formula>
-      <Formula id="CalcPecletNumber.PecletNumber_l" name="PecletNumber_l" formula="(J_iso+alpha_l*Q_lymph)*(1-sigma_l)/(P_endothelial_l*SA_pls_int)">
+      <Formula id="DistributionCommon_PKSim.PARAM_K_wat_cell" name="PARAM_K_wat_cell" formula="fu/K_cell_pls">
         <Paths>
-          <Path path="817" as="818" dim="2" />
-          <Path path="819" as="820" />
-          <Path path="967" as="163" />
-          <Path path="971" as="662" dim="168" />
-          <Path path="972" as="167" dim="168" />
-          <Path path="973" as="180" dim="181" />
+          <Path path="964" as="965" />
+          <Path path="33" as="34" dim="24" />
         </Paths>
       </Formula>
-      <Formula id="CalcPecletNumber.PecletNumber_s" name="PecletNumber_s" formula="(-J_iso+(1-alpha_l)*Q_lymph)*(1-sigma_s)/(P_endothelial_s*SA_pls_int)">
+      <Formula id="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" name="PARAM_SA_rbc_pls" dim="Area" formula="HCT * A_to_V_bc * 0.6 * V * f_vas">
         <Paths>
-          <Path path="811" as="812" dim="2" />
-          <Path path="813" as="814" />
-          <Path path="967" as="163" />
-          <Path path="971" as="662" dim="168" />
-          <Path path="972" as="167" dim="168" />
-          <Path path="973" as="180" dim="181" />
+          <Path path="966" as="136" />
+          <Path path="951" as="138" dim="55" />
+          <Path path="40" as="41" />
+          <Path path="952" as="953" dim="384" />
         </Paths>
       </Formula>
-      <BlackBoxFormula id="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" name="INTERSTITIAL PARTITION COEFFICIENT FORMULA" />
-      <Formula id="TwoPoresGammaSigma.PARAM_sigma_s" name="PARAM_sigma_s" formula="gamma&lt;1 ? 1-(1-gamma)^2*(2-(1-gamma)^2)*(1-gamma/3)/(1-gamma/3+2/3*gamma^2) : 0.999">
+      <Formula id="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" name="PARAM_SA_pls_int" dim="Area" formula="k * f_vas_org * V_org">
         <Paths>
-          <Path path="761" as="762" />
+          <Path path="966" as="967" />
+          <Path path="951" as="187" dim="55" />
+          <Path path="968" as="343" dim="384" />
         </Paths>
       </Formula>
-      <Formula id="TwoPoresGammaSigma.PARAM_sigma_l" name="PARAM_sigma_l" formula="gamma&lt;1 ? 1-(1-gamma)^2*(2-(1-gamma)^2)*(1-gamma/3)/(1-gamma/3+2/3*gamma^2) : 0.999">
+      <Formula id="DiffusionPlasma_2Poren.PARAM_P_endothelial_l" name="PARAM_P_endothelial_l" dim="Velocity" formula="gamma&lt;1 ? (1-gamma)^4.5/(1-0.3956*gamma+1.0616*gamma^2)* alpha_l*8*Lp/(r)^2 * RT/(6*Pi*Na*a_e) : 1e-22">
         <Paths>
-          <Path path="763" as="762" />
+          <Path path="804" as="805" />
+          <Path path="969" as="970" dim="127" />
+          <Path path="971" as="163" />
+          <Path path="972" as="801" dim="669" />
+          <Path path="973" as="803" dim="127" />
+          <Path path="806" as="807" dim="808" />
+          <Path path="809" as="810" dim="810" />
         </Paths>
       </Formula>
-      <Formula id="TwoPoresGammaSigma.PARAM_gamma_s" name="PARAM_gamma_s" formula="a_e / r_s">
+      <Formula id="DiffusionPlasma_2Poren.PARAM_P_endothelial" name="PARAM_P_endothelial" dim="Velocity" formula="P/2">
         <Paths>
-          <Path path="965" as="966" dim="127" />
-          <Path path="969" as="765" dim="127" />
+          <Path path="14" as="15" dim="2" />
         </Paths>
       </Formula>
-      <Formula id="TwoPoresGammaSigma.PARAM_gamma_l" name="PARAM_gamma_l" formula="a_e / r_l">
+      <Formula id="DiffusionPlasma_2Poren.PARAM_P_endothelial_s" name="PARAM_P_endothelial_s" dim="Velocity" formula="gamma&lt;1 ? (1-gamma)^4.5/(1-0.3956*gamma+1.0616*gamma^2)* (1-alpha_l)*8*Lp/(r)^2 * RT/(6*Pi*Na*a_e) : 1e-22">
         <Paths>
-          <Path path="965" as="966" dim="127" />
-          <Path path="970" as="816" dim="127" />
+          <Path path="814" as="805" />
+          <Path path="969" as="970" dim="127" />
+          <Path path="971" as="163" />
+          <Path path="972" as="801" dim="669" />
+          <Path path="974" as="803" dim="127" />
+          <Path path="806" as="807" dim="808" />
+          <Path path="809" as="810" dim="810" />
         </Paths>
       </Formula>
-      <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_bon" name="PARAM_SA_int_cell_bon" dim="Area" formula="(V_bon * 1000 / 28.2)^0.75 * 10 * 1E2">
+      <BlackBoxFormula id="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" name="INTERSTITIAL PARTITION COEFFICIENT FORMULA" />
+      <Formula id="CalcPecletNumber.PecletNumber_l" name="PecletNumber_l" formula="(J_iso+alpha_l*Q_lymph)*(1-sigma_l)/(P_endothelial_l*SA_pls_int)">
         <Paths>
-          <Path path="959" as="887" dim="50" />
+          <Path path="760" as="761" dim="2" />
+          <Path path="754" as="755" />
+          <Path path="971" as="163" />
+          <Path path="975" as="667" dim="168" />
+          <Path path="976" as="167" dim="168" />
+          <Path path="977" as="180" dim="181" />
         </Paths>
       </Formula>
-      <Formula id="DiffusionCommon_PKSim.PARAM_PA_cell_int" name="PARAM_PA_cell_int" dim="Flow" formula="P_cell_int * SA">
+      <Formula id="CalcPecletNumber.PecletNumber_s" name="PecletNumber_s" formula="(-J_iso+(1-alpha_l)*Q_lymph)*(1-sigma_s)/(P_endothelial_s*SA_pls_int)">
         <Paths>
-          <Path path="974" as="975" dim="2" />
-          <Path path="976" as="977" dim="181" />
+          <Path path="762" as="763" dim="2" />
+          <Path path="756" as="757" />
+          <Path path="971" as="163" />
+          <Path path="975" as="667" dim="168" />
+          <Path path="976" as="167" dim="168" />
+          <Path path="977" as="180" dim="181" />
         </Paths>
       </Formula>
-      <Formula id="DistributionCommon_PKSim.PARAM_K_wat_cell" name="PARAM_K_wat_cell" formula="fu/K_cell_pls">
+      <Formula id="TwoPoresGammaSigma.PARAM_gamma_l" name="PARAM_gamma_l" formula="a_e / r_l">
         <Paths>
-          <Path path="978" as="979" />
-          <Path path="33" as="34" dim="24" />
+          <Path path="969" as="970" dim="127" />
+          <Path path="973" as="815" dim="127" />
         </Paths>
       </Formula>
-      <Formula id="DiffusionCommon_PKSim.PARAM_PA_int_cell" name="PARAM_PA_int_cell" dim="Flow" formula="P_int_cell * SA">
+      <Formula id="TwoPoresGammaSigma.PARAM_gamma_s" name="PARAM_gamma_s" formula="a_e / r_s">
         <Paths>
-          <Path path="980" as="981" dim="2" />
-          <Path path="976" as="977" dim="181" />
+          <Path path="969" as="970" dim="127" />
+          <Path path="974" as="816" dim="127" />
         </Paths>
       </Formula>
-      <Formula id="DiffusionCommon_PKSim.PARAM_P_cell_int" name="PARAM_P_cell_int" dim="Velocity" formula="P * P_cell_int_factor">
+      <Formula id="TwoPoresGammaSigma.PARAM_sigma_l" name="PARAM_sigma_l" formula="gamma&lt;1 ? 1-(1-gamma)^2*(2-(1-gamma)^2)*(1-gamma/3)/(1-gamma/3+2/3*gamma^2) : 0.999">
         <Paths>
-          <Path path="982" as="983" />
-          <Path path="7" as="8" dim="2" />
+          <Path path="804" as="805" />
         </Paths>
       </Formula>
-      <Formula id="DiffusionCommon_PKSim.PARAM_P_int_cell" name="PARAM_P_int_cell" dim="Velocity" formula="P * P_int_cell_factor">
+      <Formula id="TwoPoresGammaSigma.PARAM_sigma_s" name="PARAM_sigma_s" formula="gamma&lt;1 ? 1-(1-gamma)^2*(2-(1-gamma)^2)*(1-gamma/3)/(1-gamma/3+2/3*gamma^2) : 0.999">
         <Paths>
-          <Path path="984" as="985" />
-          <Path path="7" as="8" dim="2" />
+          <Path path="814" as="805" />
         </Paths>
       </Formula>
       <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_brn" name="PARAM_SA_int_cell_brn" dim="Area" formula="(V_brn  * 1000 / 1.671)^0.75 * 0.0006 * 1E2">
         <Paths>
-          <Path path="959" as="888" dim="50" />
+          <Path path="951" as="880" dim="55" />
         </Paths>
       </Formula>
       <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_fat" name="PARAM_SA_int_cell_fat" dim="Area" formula="(V_fat * 1000 / 14.2)^0.75 * 5 * 1E2">
         <Paths>
-          <Path path="959" as="889" dim="50" />
+          <Path path="951" as="881" dim="55" />
         </Paths>
       </Formula>
       <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_tes" name="PARAM_SA_int_cell_tes" dim="Area" formula="(V_tes * 1000 / 2.5)^0.75 * 2 * 1E2">
         <Paths>
-          <Path path="959" as="890" dim="50" />
+          <Path path="951" as="882" dim="55" />
         </Paths>
       </Formula>
       <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_hrt" name="PARAM_SA_int_cell_hrt" dim="Area" formula="(V_hrt * 1000 / 1.2)^0.75 * 7.54 * 1E2">
         <Paths>
-          <Path path="959" as="891" dim="50" />
+          <Path path="951" as="883" dim="55" />
         </Paths>
       </Formula>
-      <Formula id="MassTransferLink_forTwoPores.PARAM_MassTransferMucosaToPvePlasma" name="PARAM_MassTransferMucosaToPvePlasma" dim="Amount per time" formula="(Q*(1-HCT)-Q_lymph)*C_pls">
+      <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_kid" name="PARAM_SA_int_cell_kid" dim="Area" formula="(V_kid * 1000 / 7)^0.75 * 1000 * 1E2">
         <Paths>
-          <Path path="986" as="987" dim="141" />
-          <Path path="988" as="174" dim="168" />
-          <Path path="972" as="167" dim="168" />
-          <Path path="40" as="41" />
+          <Path path="951" as="884" dim="55" />
+        </Paths>
+      </Formula>
+      <Formula id="DistributionCommon_PKSim.PARAM_K_water_cell_Kidney" name="PARAM_K_water_cell_Kidney" formula="K_water_cell">
+        <Paths>
+          <Path path="244" as="197" />
+        </Paths>
+      </Formula>
+      <Formula id="Lumen_PKSim.PARAM_DrugAbsorption_para" name="PARAM_DrugAbsorption_para" dim="Amount per time" formula="OralApplicationsEnabled ? P_int_para*Aeff*(EffectiveLumenConcentration-(NOT SinkCondition_para ? fu*DrugMucosa : 0)) : 0">
+        <Paths>
+          <Path path="978" as="979" dim="181" />
+          <Path path="980" as="981" dim="141" />
+          <Path path="982" as="983" dim="141" />
+          <Path path="33" as="34" dim="24" />
+          <Path path="984" as="985" dim="2" />
+          <Path path="986" as="266" />
+          <Path path="987" as="988" />
         </Paths>
       </Formula>
       <SumFormula id="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" name="PARAM_SumOfActiveProcessRates" dim="Amount per time" variable="P" formulaString="P_#i">
@@ -25832,13 +25920,6 @@
           </DescriptorConditions>
         </Criteria>
       </SumFormula>
-      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K8" name="PARAM_pKa_pH_WS_lum_K8" formula="(1-F1)*(1-F2)*(1-F3)">
-        <Paths>
-          <Path path="278" as="279" />
-          <Path path="280" as="281" />
-          <Path path="282" as="283" />
-        </Paths>
-      </Formula>
       <SumFormula id="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" name="PARAM_SumOfPassiveProcessRates" dim="Amount per time" variable="P" formulaString="P_#i">
         <Criteria>
           <DescriptorConditions>
@@ -25849,1116 +25930,1104 @@
           </DescriptorConditions>
         </Criteria>
       </SumFormula>
-      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F2" name="PARAM_pKa_pH_WS_lum_F2" formula="CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1">
+      <Formula id="Lumen_PKSim.PARAM_DrugAbsorption_trans" name="PARAM_DrugAbsorption_trans" dim="Amount per time" formula="OralApplicationsEnabled ? P_int_trans*Aeff*(P_int_trans_lum_cell_factor*EffectiveLumenConcentration-(NOT SinkCondition_trans ? P_int_trans_cell_lum_factor*fu/K_cell_pls*DrugMucosa : 0)) : 0">
         <Paths>
-          <Path path="989" as="292" />
-          <Path path="293" as="294" />
-          <Path path="287" as="288" />
-          <Path path="295" as="296" />
+          <Path path="964" as="965" />
+          <Path path="978" as="979" dim="181" />
+          <Path path="980" as="981" dim="141" />
+          <Path path="982" as="983" dim="141" />
+          <Path path="33" as="34" dim="24" />
+          <Path path="989" as="11" dim="2" />
+          <Path path="990" as="991" />
+          <Path path="992" as="993" />
+          <Path path="986" as="266" />
+          <Path path="994" as="995" />
         </Paths>
       </Formula>
-      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F3" name="PARAM_pKa_pH_WS_mucosacell_F3" formula="CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1">
+      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_cell_lum_factor" name="PARAM_P_int_trans_cell_lum_factor" formula="UsePenaltyFactor ? K1+ (K2 +K3 +K4)* base ^ 1 + K5* base ^ max(CT0+CT1;-CT0-CT1) +K6* base ^ max(CT0+CT2;-CT0-CT2) +K7* base ^ max(CT2+CT1;-CT2-CT1) +K8* base ^ max(CT0+CT1+CT2;-CT0-CT1-CT2) : 1">
         <Paths>
-          <Path path="297" as="298" />
+          <Path path="996" as="314" />
+          <Path path="997" as="316" />
+          <Path path="998" as="318" />
+          <Path path="999" as="320" />
+          <Path path="1000" as="322" />
+          <Path path="1001" as="324" />
+          <Path path="1002" as="326" />
+          <Path path="1003" as="328" />
+          <Path path="281" as="282" />
           <Path path="287" as="288" />
-          <Path path="299" as="300" />
-          <Path path="990" as="292" />
+          <Path path="291" as="292" />
+          <Path path="1004" as="1005" />
+          <Path path="1006" as="330" />
         </Paths>
       </Formula>
-      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K1" name="PARAM_pKa_pH_WS_mucosacell_K1" formula="F1*F2*F3">
+      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_lum_cell_factor" name="PARAM_P_int_trans_lum_cell_factor" formula="UsePenaltyFactor ? K1+ (K2 +K3 +K4)* base ^ 1 + K5* base ^ max(CT0+CT1;-CT0-CT1) +K6* base ^ max(CT0+CT2;-CT0-CT2) +K7* base ^ max(CT2+CT1;-CT2-CT1) +K8* base ^ max(CT0+CT1+CT2;-CT0-CT1-CT2) : 1">
         <Paths>
-          <Path path="991" as="279" />
-          <Path path="992" as="281" />
-          <Path path="993" as="283" />
+          <Path path="313" as="314" />
+          <Path path="315" as="316" />
+          <Path path="317" as="318" />
+          <Path path="319" as="320" />
+          <Path path="321" as="322" />
+          <Path path="323" as="324" />
+          <Path path="325" as="326" />
+          <Path path="327" as="328" />
+          <Path path="281" as="282" />
+          <Path path="287" as="288" />
+          <Path path="291" as="292" />
+          <Path path="1004" as="1005" />
+          <Path path="1006" as="330" />
         </Paths>
       </Formula>
-      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K2" name="PARAM_pKa_pH_WS_mucosacell_K2" formula="(1-F1)*F2*F3">
+      <Formula id="Lumen_PKSim.PARAM_K_cell_pls_UpperJejunum" name="PARAM_K_cell_pls_UpperJejunum" formula="K_cell_pls">
         <Paths>
-          <Path path="991" as="279" />
-          <Path path="992" as="281" />
-          <Path path="993" as="283" />
+          <Path path="1007" as="965" />
         </Paths>
       </Formula>
-      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K3" name="PARAM_pKa_pH_WS_mucosacell_K3" formula="F1*(1-F2)*F3">
+      <Formula id="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_UpperJejunum" name="PARAM_K_wat_cell_Lumen_UpperJejunum" formula="K_water_cell">
         <Paths>
-          <Path path="991" as="279" />
-          <Path path="992" as="281" />
-          <Path path="993" as="283" />
+          <Path path="570" as="197" />
         </Paths>
       </Formula>
-      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K4" name="PARAM_pKa_pH_WS_mucosacell_K4" formula="F1*F2*(1-F3)">
+      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F1" name="PARAM_pKa_pH_WS_mucosacell_F1" formula="CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1">
         <Paths>
-          <Path path="991" as="279" />
-          <Path path="992" as="281" />
-          <Path path="993" as="283" />
+          <Path path="279" as="280" />
+          <Path path="281" as="282" />
+          <Path path="283" as="284" />
+          <Path path="1008" as="286" />
         </Paths>
       </Formula>
-      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K5" name="PARAM_pKa_pH_WS_mucosacell_K5" formula="(1-F1)*(1-F2)*F3">
+      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F2" name="PARAM_pKa_pH_WS_mucosacell_F2" formula="CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1">
         <Paths>
-          <Path path="991" as="279" />
-          <Path path="992" as="281" />
-          <Path path="993" as="283" />
+          <Path path="279" as="280" />
+          <Path path="287" as="288" />
+          <Path path="289" as="290" />
+          <Path path="1008" as="286" />
         </Paths>
       </Formula>
-      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K6" name="PARAM_pKa_pH_WS_mucosacell_K6" formula="(1-F1)*F2*(1-F3)">
+      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F3" name="PARAM_pKa_pH_WS_mucosacell_F3" formula="CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1">
         <Paths>
-          <Path path="991" as="279" />
-          <Path path="992" as="281" />
-          <Path path="993" as="283" />
+          <Path path="279" as="280" />
+          <Path path="291" as="292" />
+          <Path path="293" as="294" />
+          <Path path="1008" as="286" />
         </Paths>
       </Formula>
-      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K7" name="PARAM_pKa_pH_WS_mucosacell_K7" formula="F1*(1-F2)*(1-F3)">
+      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K1" name="PARAM_pKa_pH_WS_mucosacell_K1" formula="F1*F2*F3">
         <Paths>
-          <Path path="991" as="279" />
-          <Path path="992" as="281" />
-          <Path path="993" as="283" />
+          <Path path="1009" as="296" />
+          <Path path="1010" as="298" />
+          <Path path="1011" as="300" />
         </Paths>
       </Formula>
-      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F1" name="PARAM_pKa_pH_WS_lum_F1" formula="CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1">
+      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K2" name="PARAM_pKa_pH_WS_mucosacell_K2" formula="(1-F1)*F2*F3">
         <Paths>
-          <Path path="989" as="292" />
-          <Path path="285" as="286" />
-          <Path path="287" as="288" />
-          <Path path="289" as="290" />
+          <Path path="1009" as="296" />
+          <Path path="1010" as="298" />
+          <Path path="1011" as="300" />
         </Paths>
       </Formula>
-      <Formula id="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_UpperJejunum" name="PARAM_K_wat_cell_Lumen_UpperJejunum" formula="K_water_cell">
+      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K3" name="PARAM_pKa_pH_WS_mucosacell_K3" formula="F1*(1-F2)*F3">
         <Paths>
-          <Path path="560" as="197" />
+          <Path path="1009" as="296" />
+          <Path path="1010" as="298" />
+          <Path path="1011" as="300" />
         </Paths>
       </Formula>
-      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F3" name="PARAM_pKa_pH_WS_lum_F3" formula="CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1">
+      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K4" name="PARAM_pKa_pH_WS_mucosacell_K4" formula="F1*F2*(1-F3)">
         <Paths>
-          <Path path="989" as="292" />
-          <Path path="297" as="298" />
-          <Path path="287" as="288" />
-          <Path path="299" as="300" />
+          <Path path="1009" as="296" />
+          <Path path="1010" as="298" />
+          <Path path="1011" as="300" />
         </Paths>
       </Formula>
-      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K1" name="PARAM_pKa_pH_WS_lum_K1" formula="F1*F2*F3">
+      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K5" name="PARAM_pKa_pH_WS_mucosacell_K5" formula="(1-F1)*(1-F2)*F3">
         <Paths>
-          <Path path="278" as="279" />
-          <Path path="280" as="281" />
-          <Path path="282" as="283" />
+          <Path path="1009" as="296" />
+          <Path path="1010" as="298" />
+          <Path path="1011" as="300" />
         </Paths>
       </Formula>
-      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K2" name="PARAM_pKa_pH_WS_lum_K2" formula="(1-F1)*F2*F3">
+      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K6" name="PARAM_pKa_pH_WS_mucosacell_K6" formula="(1-F1)*F2*(1-F3)">
         <Paths>
-          <Path path="278" as="279" />
-          <Path path="280" as="281" />
-          <Path path="282" as="283" />
+          <Path path="1009" as="296" />
+          <Path path="1010" as="298" />
+          <Path path="1011" as="300" />
         </Paths>
       </Formula>
-      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K3" name="PARAM_pKa_pH_WS_lum_K3" formula="F1*(1-F2)*F3">
+      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K7" name="PARAM_pKa_pH_WS_mucosacell_K7" formula="F1*(1-F2)*(1-F3)">
         <Paths>
-          <Path path="278" as="279" />
-          <Path path="280" as="281" />
-          <Path path="282" as="283" />
+          <Path path="1009" as="296" />
+          <Path path="1010" as="298" />
+          <Path path="1011" as="300" />
         </Paths>
       </Formula>
-      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K4" name="PARAM_pKa_pH_WS_lum_K4" formula="F1*F2*(1-F3)">
+      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K8" name="PARAM_pKa_pH_WS_mucosacell_K8" formula="(1-F1)*(1-F2)*(1-F3)">
         <Paths>
-          <Path path="278" as="279" />
-          <Path path="280" as="281" />
-          <Path path="282" as="283" />
+          <Path path="1009" as="296" />
+          <Path path="1010" as="298" />
+          <Path path="1011" as="300" />
         </Paths>
       </Formula>
-      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K5" name="PARAM_pKa_pH_WS_lum_K5" formula="(1-F1)*(1-F2)*F3">
+      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F1" name="PARAM_pKa_pH_WS_lum_F1" formula="CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1">
         <Paths>
-          <Path path="278" as="279" />
-          <Path path="280" as="281" />
-          <Path path="282" as="283" />
+          <Path path="1012" as="286" />
+          <Path path="279" as="280" />
+          <Path path="281" as="282" />
+          <Path path="283" as="284" />
         </Paths>
       </Formula>
-      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K6" name="PARAM_pKa_pH_WS_lum_K6" formula="(1-F1)*F2*(1-F3)">
+      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F2" name="PARAM_pKa_pH_WS_lum_F2" formula="CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1">
         <Paths>
-          <Path path="278" as="279" />
-          <Path path="280" as="281" />
-          <Path path="282" as="283" />
+          <Path path="1012" as="286" />
+          <Path path="279" as="280" />
+          <Path path="287" as="288" />
+          <Path path="289" as="290" />
         </Paths>
       </Formula>
-      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K7" name="PARAM_pKa_pH_WS_lum_K7" formula="F1*(1-F2)*(1-F3)">
+      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F3" name="PARAM_pKa_pH_WS_lum_F3" formula="CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1">
         <Paths>
-          <Path path="278" as="279" />
-          <Path path="280" as="281" />
-          <Path path="282" as="283" />
+          <Path path="1012" as="286" />
+          <Path path="279" as="280" />
+          <Path path="291" as="292" />
+          <Path path="293" as="294" />
         </Paths>
       </Formula>
-      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K8" name="PARAM_pKa_pH_WS_mucosacell_K8" formula="(1-F1)*(1-F2)*(1-F3)">
+      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K1" name="PARAM_pKa_pH_WS_lum_K1" formula="F1*F2*F3">
         <Paths>
-          <Path path="991" as="279" />
-          <Path path="992" as="281" />
-          <Path path="993" as="283" />
+          <Path path="295" as="296" />
+          <Path path="297" as="298" />
+          <Path path="299" as="300" />
         </Paths>
       </Formula>
-      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F2" name="PARAM_pKa_pH_WS_mucosacell_F2" formula="CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1">
+      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K2" name="PARAM_pKa_pH_WS_lum_K2" formula="(1-F1)*F2*F3">
         <Paths>
-          <Path path="293" as="294" />
-          <Path path="287" as="288" />
           <Path path="295" as="296" />
-          <Path path="990" as="292" />
+          <Path path="297" as="298" />
+          <Path path="299" as="300" />
         </Paths>
       </Formula>
-      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F1" name="PARAM_pKa_pH_WS_mucosacell_F1" formula="CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1">
+      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K3" name="PARAM_pKa_pH_WS_lum_K3" formula="F1*(1-F2)*F3">
         <Paths>
-          <Path path="285" as="286" />
-          <Path path="287" as="288" />
-          <Path path="289" as="290" />
-          <Path path="990" as="292" />
+          <Path path="295" as="296" />
+          <Path path="297" as="298" />
+          <Path path="299" as="300" />
         </Paths>
       </Formula>
-      <Formula id="Lumen_PKSim.PARAM_DrugAbsorption_trans" name="PARAM_DrugAbsorption_trans" dim="Amount per time" formula="OralApplicationsEnabled ? P_int_trans*Aeff*(P_int_trans_lum_cell_factor*min(Solubility/ MW ;DrugLiquid/(Liquid))-(NOT SinkCondition_trans ? P_int_trans_cell_lum_factor*fu/K_cell_pls*DrugMucosa : 0)) : 0">
+      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K4" name="PARAM_pKa_pH_WS_lum_K4" formula="F1*F2*(1-F3)">
         <Paths>
-          <Path path="978" as="979" />
-          <Path path="994" as="995" dim="181" />
-          <Path path="996" as="248" dim="50" />
-          <Path path="997" as="998" dim="999" />
-          <Path path="1000" as="1001" dim="141" />
-          <Path path="33" as="34" dim="24" />
-          <Path path="1002" as="4" dim="2" />
-          <Path path="1003" as="1004" dim="1005" />
-          <Path path="1006" as="1007" />
-          <Path path="1008" as="1009" />
-          <Path path="1010" as="307" dim="303" />
-          <Path path="1011" as="266" />
-          <Path path="1012" as="1013" />
+          <Path path="295" as="296" />
+          <Path path="297" as="298" />
+          <Path path="299" as="300" />
         </Paths>
       </Formula>
-      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_cell_lum_factor" name="PARAM_P_int_trans_cell_lum_factor" formula="UsePenaltyFactor ? K1+ (K2 +K3 +K4)* base ^ 1 + K5* base ^ max(CT0+CT1;-CT0-CT1) +K6* base ^ max(CT0+CT2;-CT0-CT2) +K7* base ^ max(CT2+CT1;-CT2-CT1) +K8* base ^ max(CT0+CT1+CT2;-CT0-CT1-CT2) : 1">
+      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K5" name="PARAM_pKa_pH_WS_lum_K5" formula="(1-F1)*(1-F2)*F3">
         <Paths>
-          <Path path="1014" as="314" />
-          <Path path="1015" as="316" />
-          <Path path="1016" as="318" />
-          <Path path="1017" as="320" />
-          <Path path="1018" as="322" />
-          <Path path="1019" as="324" />
-          <Path path="1020" as="326" />
-          <Path path="1021" as="328" />
-          <Path path="1022" as="330" />
-          <Path path="285" as="286" />
-          <Path path="293" as="294" />
+          <Path path="295" as="296" />
           <Path path="297" as="298" />
-          <Path path="1023" as="1024" />
+          <Path path="299" as="300" />
         </Paths>
       </Formula>
-      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_lum_cell_factor" name="PARAM_P_int_trans_lum_cell_factor" formula="UsePenaltyFactor ? K1+ (K2 +K3 +K4)* base ^ 1 + K5* base ^ max(CT0+CT1;-CT0-CT1) +K6* base ^ max(CT0+CT2;-CT0-CT2) +K7* base ^ max(CT2+CT1;-CT2-CT1) +K8* base ^ max(CT0+CT1+CT2;-CT0-CT1-CT2) : 1">
+      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K6" name="PARAM_pKa_pH_WS_lum_K6" formula="(1-F1)*F2*(1-F3)">
         <Paths>
-          <Path path="313" as="314" />
-          <Path path="315" as="316" />
-          <Path path="317" as="318" />
-          <Path path="319" as="320" />
-          <Path path="321" as="322" />
-          <Path path="323" as="324" />
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-          <Path path="327" as="328" />
-          <Path path="1022" as="330" />
-          <Path path="285" as="286" />
-          <Path path="293" as="294" />
+          <Path path="295" as="296" />
           <Path path="297" as="298" />
-          <Path path="1023" as="1024" />
+          <Path path="299" as="300" />
         </Paths>
       </Formula>
-      <Formula id="Lumen_PKSim.PARAM_K_cell_pls_UpperJejunum" name="PARAM_K_cell_pls_UpperJejunum" formula="K_cell_pls">
+      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K7" name="PARAM_pKa_pH_WS_lum_K7" formula="F1*(1-F2)*(1-F3)">
         <Paths>
-          <Path path="1025" as="979" />
+          <Path path="295" as="296" />
+          <Path path="297" as="298" />
+          <Path path="299" as="300" />
         </Paths>
       </Formula>
-      <Formula id="Lumen_PKSim.PARAM_DrugAbsorption_para" name="PARAM_DrugAbsorption_para" dim="Amount per time" formula="OralApplicationsEnabled ? P_int_para*Aeff*(min(Solubility/ MW ;DrugLiquid/(Liquid))-(NOT SinkCondition_para ? fu*DrugMucosa : 0)) : 0">
+      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K8" name="PARAM_pKa_pH_WS_lum_K8" formula="(1-F1)*(1-F2)*(1-F3)">
         <Paths>
-          <Path path="994" as="995" dim="181" />
-          <Path path="996" as="248" dim="50" />
-          <Path path="997" as="998" dim="999" />
-          <Path path="1000" as="1001" dim="141" />
-          <Path path="33" as="34" dim="24" />
-          <Path path="1026" as="1027" dim="2" />
-          <Path path="1003" as="1004" dim="1005" />
-          <Path path="1010" as="307" dim="303" />
-          <Path path="1011" as="266" />
-          <Path path="1028" as="1029" />
+          <Path path="295" as="296" />
+          <Path path="297" as="298" />
+          <Path path="299" as="300" />
         </Paths>
       </Formula>
-      <Formula id="MassTransferLink_forTwoPores.PARAM_MassTransferMucosaToPveBloodCells" name="PARAM_MassTransferMucosaToPveBloodCells" dim="Amount per time" formula="Q*HCT*C_bc">
+      <Formula id="MassTransferLink_forTwoPores.PARAM_MassTransferMucosaToPvePlasma" name="PARAM_MassTransferMucosaToPvePlasma" dim="Amount per time" formula="(Q*(1-HCT)-Q_lymph)*C_pls">
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-          <Path path="986" as="1030" dim="141" />
-          <Path path="988" as="174" dim="168" />
+          <Path path="1013" as="1014" dim="141" />
+          <Path path="1015" as="174" dim="168" />
+          <Path path="976" as="167" dim="168" />
           <Path path="40" as="41" />
         </Paths>
       </Formula>
-      <Formula id="DistributionCommon_PKSim.PARAM_K_water_cell_Kidney" name="PARAM_K_water_cell_Kidney" formula="K_water_cell">
-        <Paths>
-          <Path path="244" as="197" />
-        </Paths>
-      </Formula>
-      <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_kid" name="PARAM_SA_int_cell_kid" dim="Area" formula="(V_kid * 1000 / 7)^0.75 * 1000 * 1E2">
+      <Formula id="MassTransferLink_forTwoPores.PARAM_MassTransferMucosaToPveBloodCells" name="PARAM_MassTransferMucosaToPveBloodCells" dim="Amount per time" formula="Q*HCT*C_bc">
         <Paths>
-          <Path path="959" as="892" dim="50" />
+          <Path path="1013" as="1016" dim="141" />
+          <Path path="1015" as="174" dim="168" />
+          <Path path="40" as="41" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_K_cell_pls_LowerJejunum" name="PARAM_K_cell_pls_LowerJejunum" formula="K_cell_pls">
         <Paths>
-          <Path path="1031" as="979" />
+          <Path path="1017" as="965" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_LowerJejunum" name="PARAM_K_wat_cell_Lumen_LowerJejunum" formula="K_water_cell">
         <Paths>
-          <Path path="564" as="197" />
+          <Path path="574" as="197" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_OralMassAbsorbed" name="PARAM_OralMassAbsorbed" dim="Amount" formula="MAbs_duo + MAbs_uje + MAbs_lje + MAbs_uil + MAbs_lil + MAbs_cae + MAbs_colasc + MAbs_coltrans + MAbs_coldesc + MAbs_colsigm + MAbs_rect">
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-          <Path path="1034" as="1035" dim="999" />
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-          <Path path="1048" as="1049" dim="999" />
-          <Path path="1050" as="1051" dim="999" />
-          <Path path="1052" as="1053" dim="999" />
+          <Path path="1018" as="1019" dim="334" />
+          <Path path="1020" as="1021" dim="334" />
+          <Path path="1022" as="1023" dim="334" />
+          <Path path="1024" as="1025" dim="334" />
+          <Path path="1026" as="1027" dim="334" />
+          <Path path="1028" as="1029" dim="334" />
+          <Path path="1030" as="1031" dim="334" />
+          <Path path="1032" as="1033" dim="334" />
+          <Path path="1034" as="1035" dim="334" />
+          <Path path="1036" as="1037" dim="334" />
+          <Path path="1038" as="1039" dim="334" />
         </Paths>
       </Formula>
       <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_sto" name="PARAM_SA_int_cell_sto" dim="Area" formula="(V_sto * 1000 / 1.1)^0.75 * 1000 * 1E2">
         <Paths>
-          <Path path="959" as="901" dim="50" />
+          <Path path="951" as="893" dim="55" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_K_cell_pls_UpperIleum" name="PARAM_K_cell_pls_UpperIleum" formula="K_cell_pls">
         <Paths>
-          <Path path="1054" as="979" />
+          <Path path="1040" as="965" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_UpperIleum" name="PARAM_K_wat_cell_Lumen_UpperIleum" formula="K_water_cell">
         <Paths>
-          <Path path="568" as="197" />
+          <Path path="578" as="197" />
         </Paths>
       </Formula>
-      <Formula id="MassTransferLink_forTwoPores.PARAM_MassTransferIntestineToMucosaPlasma" name="PARAM_MassTransferIntestineToMucosaPlasma" dim="Amount per time" formula="(Q*(1-HCT)-Q_lymph)*C_pls">
+      <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_sin" name="PARAM_SA_int_cell_sin" dim="Area" formula="((V_sin-V_Mucosa) * 1000 / 11.1)^0.75 * 1000 * 1E2">
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-          <Path path="1056" as="167" dim="168" />
-          <Path path="986" as="987" dim="141" />
-          <Path path="40" as="41" />
+          <Path path="951" as="891" dim="55" />
+          <Path path="1041" as="545" dim="55" />
         </Paths>
       </Formula>
-      <Formula id="Lumen_PKSim.PARAM_K_cell_pls_LowerIleum" name="PARAM_K_cell_pls_LowerIleum" formula="K_cell_pls">
+      <Formula id="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls_sinlin" name="PARAM_SA_rbc_pls_sinlin" dim="Area" formula="HCT * A_to_V_bc * 0.6 * (V-V_Mucosa) * f_vas">
         <Paths>
-          <Path path="1057" as="979" />
+          <Path path="966" as="136" />
+          <Path path="951" as="138" dim="55" />
+          <Path path="1042" as="545" dim="55" />
+          <Path path="40" as="41" />
+          <Path path="952" as="953" dim="384" />
         </Paths>
       </Formula>
-      <Formula id="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_LowerIleum" name="PARAM_K_wat_cell_Lumen_LowerIleum" formula="K_water_cell">
+      <Formula id="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int_sinlin" name="PARAM_SA_pls_int_sinlin" dim="Area" formula="k * f_vas_org * (V_org-V_Mucosa)">
         <Paths>
-          <Path path="572" as="197" />
+          <Path path="966" as="967" />
+          <Path path="951" as="187" dim="55" />
+          <Path path="1042" as="545" dim="55" />
+          <Path path="968" as="343" dim="384" />
         </Paths>
       </Formula>
-      <Formula id="MassTransferLink_forTwoPores.PARAM_MassTransferIntestineToMucosaBloodCells" name="PARAM_MassTransferIntestineToMucosaBloodCells" dim="Amount per time" formula="Q*HCT*C_bc">
+      <Formula id="MassTransferLink_forTwoPores.PARAM_MassTransferIntestineToMucosaPlasma" name="PARAM_MassTransferIntestineToMucosaPlasma" dim="Amount per time" formula="(Q*(1-HCT)-Q_lymph)*C_pls">
         <Paths>
-          <Path path="1055" as="174" dim="168" />
-          <Path path="986" as="1030" dim="141" />
+          <Path path="1043" as="174" dim="168" />
+          <Path path="1044" as="167" dim="168" />
+          <Path path="1013" as="1014" dim="141" />
           <Path path="40" as="41" />
         </Paths>
       </Formula>
-      <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_sin" name="PARAM_SA_int_cell_sin" dim="Area" formula="((V_sin-V_Mucosa) * 1000 / 11.1)^0.75 * 1000 * 1E2">
+      <Formula id="MassTransferLink_forTwoPores.PARAM_MassTransferIntestineToMucosaBloodCells" name="PARAM_MassTransferIntestineToMucosaBloodCells" dim="Amount per time" formula="Q*HCT*C_bc">
         <Paths>
-          <Path path="959" as="899" dim="50" />
-          <Path path="1058" as="535" dim="50" />
+          <Path path="1043" as="174" dim="168" />
+          <Path path="1013" as="1016" dim="141" />
+          <Path path="40" as="41" />
         </Paths>
       </Formula>
-      <Formula id="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls_sinlin" name="PARAM_SA_rbc_pls_sinlin" dim="Area" formula="HCT * A_to_V_bc * 0.6 * (V-V_Mucosa) * f_vas">
+      <Formula id="Lumen_PKSim.PARAM_K_cell_pls_LowerIleum" name="PARAM_K_cell_pls_LowerIleum" formula="K_cell_pls">
         <Paths>
-          <Path path="962" as="136" />
-          <Path path="959" as="138" dim="50" />
-          <Path path="1059" as="535" dim="50" />
-          <Path path="40" as="41" />
-          <Path path="960" as="961" dim="356" />
+          <Path path="1045" as="965" />
         </Paths>
       </Formula>
-      <Formula id="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int_sinlin" name="PARAM_SA_pls_int_sinlin" dim="Area" formula="k * f_vas_org * (V_org-V_Mucosa)">
+      <Formula id="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_LowerIleum" name="PARAM_K_wat_cell_Lumen_LowerIleum" formula="K_water_cell">
         <Paths>
-          <Path path="962" as="963" />
-          <Path path="959" as="187" dim="50" />
-          <Path path="1059" as="535" dim="50" />
-          <Path path="964" as="360" dim="356" />
+          <Path path="582" as="197" />
         </Paths>
       </Formula>
       <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_lin" name="PARAM_SA_int_cell_lin" dim="Area" formula="((V_lin-V_Mucosa) * 1000 / 11.1)^0.75 * 1000 * 1E2">
         <Paths>
-          <Path path="959" as="893" dim="50" />
-          <Path path="1060" as="535" dim="50" />
+          <Path path="951" as="885" dim="55" />
+          <Path path="1046" as="545" dim="55" />
         </Paths>
       </Formula>
       <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_liv" name="PARAM_SA_int_cell_liv" dim="Area" formula="(V_liv * 1000 / 10)^0.75 * 82 * 1E2">
         <Paths>
-          <Path path="959" as="654" dim="50" />
+          <Path path="951" as="664" dim="55" />
         </Paths>
       </Formula>
       <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_periportal" name="PARAM_SA_int_cell_periportal" dim="Area" formula="SA_int_cell * (IsLiverZonated?  f_periportal : 1)">
         <Paths>
-          <Path path="649" as="650" dim="24" />
-          <Path path="651" as="652" />
-          <Path path="1061" as="1062" dim="181" />
+          <Path path="659" as="660" dim="24" />
+          <Path path="661" as="662" />
+          <Path path="1047" as="1048" dim="181" />
         </Paths>
       </Formula>
       <Formula id="SurfaceAreaRbcPls_PKSim.PARAM_SA_pls_bc_periportal" name="PARAM_SA_pls_bc_periportal" dim="Area" formula="SA_pls_bc * (IsLiverZonated?  f_periportal : 1)">
         <Paths>
-          <Path path="649" as="650" dim="24" />
-          <Path path="651" as="652" />
-          <Path path="1063" as="1064" dim="181" />
+          <Path path="659" as="660" dim="24" />
+          <Path path="661" as="662" />
+          <Path path="1049" as="1050" dim="181" />
         </Paths>
       </Formula>
       <Formula id="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int_periportal" name="PARAM_SA_pls_int_periportal" dim="Area" formula="SA_pls_int * (IsLiverZonated?  f_periportal : 1)">
         <Paths>
-          <Path path="649" as="650" dim="24" />
-          <Path path="651" as="652" />
-          <Path path="640" as="180" dim="181" />
+          <Path path="659" as="660" dim="24" />
+          <Path path="661" as="662" />
+          <Path path="650" as="180" dim="181" />
         </Paths>
       </Formula>
-      <Formula id="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int_pericentral" name="PARAM_SA_pls_int_pericentral" dim="Area" formula="SA_pls_int * (IsLiverZonated?  1-f_periportal : 0)">
+      <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_pericentral" name="PARAM_SA_int_cell_pericentral" dim="Area" formula="SA_int_cell * (IsLiverZonated?  1-f_periportal : 0)">
         <Paths>
-          <Path path="649" as="650" dim="24" />
-          <Path path="651" as="652" />
-          <Path path="640" as="180" dim="181" />
+          <Path path="659" as="660" dim="24" />
+          <Path path="661" as="662" />
+          <Path path="1047" as="1048" dim="181" />
         </Paths>
       </Formula>
       <Formula id="SurfaceAreaRbcPls_PKSim.PARAM_SA_pls_bc_pericentral" name="PARAM_SA_pls_bc_pericentral" dim="Area" formula="SA_pls_bc * (IsLiverZonated?  1-f_periportal : 0)">
         <Paths>
-          <Path path="649" as="650" dim="24" />
-          <Path path="651" as="652" />
-          <Path path="1063" as="1064" dim="181" />
+          <Path path="659" as="660" dim="24" />
+          <Path path="661" as="662" />
+          <Path path="1049" as="1050" dim="181" />
         </Paths>
       </Formula>
-      <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_pericentral" name="PARAM_SA_int_cell_pericentral" dim="Area" formula="SA_int_cell * (IsLiverZonated?  1-f_periportal : 0)">
+      <Formula id="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int_pericentral" name="PARAM_SA_pls_int_pericentral" dim="Area" formula="SA_pls_int * (IsLiverZonated?  1-f_periportal : 0)">
         <Paths>
-          <Path path="649" as="650" dim="24" />
-          <Path path="651" as="652" />
-          <Path path="1061" as="1062" dim="181" />
+          <Path path="659" as="660" dim="24" />
+          <Path path="661" as="662" />
+          <Path path="650" as="180" dim="181" />
         </Paths>
       </Formula>
       <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_lng" name="PARAM_SA_int_cell_lng" dim="Area" formula="(V_lng * 1000  / 2.2)^0.75 * 0.096 * 1E2">
         <Paths>
-          <Path path="959" as="895" dim="50" />
+          <Path path="951" as="887" dim="55" />
         </Paths>
       </Formula>
       <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mus" name="PARAM_SA_int_cell_mus" dim="Area" formula="(V_mus * 1000 / 110.1)^0.75 * 7.54 * 1E2">
         <Paths>
-          <Path path="959" as="896" dim="50" />
+          <Path path="951" as="888" dim="55" />
         </Paths>
       </Formula>
       <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_pan" name="PARAM_SA_int_cell_pan" dim="Area" formula="(V_pan * 1000 / 1.3)^0.75 * 1000 * 1E2">
         <Paths>
-          <Path path="959" as="897" dim="50" />
+          <Path path="951" as="889" dim="55" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_K_cell_pls_Rectum" name="PARAM_K_cell_pls_Rectum" formula="K_cell_pls">
         <Paths>
-          <Path path="1065" as="979" />
+          <Path path="1051" as="965" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_Rectum" name="PARAM_K_wat_cell_Lumen_Rectum" formula="K_water_cell">
         <Paths>
-          <Path path="639" as="197" />
+          <Path path="649" as="197" />
         </Paths>
       </Formula>
       <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_skn" name="PARAM_SA_int_cell_skn" dim="Area" formula="(V_skn * 1000 / 43.4)^0.75 * 0.12 * 1E2">
         <Paths>
-          <Path path="959" as="898" dim="50" />
+          <Path path="951" as="890" dim="55" />
         </Paths>
       </Formula>
       <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_spl" name="PARAM_SA_int_cell_spl" dim="Area" formula="(V_spl * 1000 / 1.3)^0.75 * 1000 * 1E2">
         <Paths>
-          <Path path="959" as="900" dim="50" />
+          <Path path="951" as="892" dim="55" />
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       </Formula>
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+      <Formula id="Lumen_PKSim.PARAM_K_cell_pls_Duodenum" name="PARAM_K_cell_pls_Duodenum" formula="K_cell_pls">
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-      <Formula id="Lumen_PKSim.PARAM_K_cell_pls_Duodenum" name="PARAM_K_cell_pls_Duodenum" formula="K_cell_pls">
+      <Formula id="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_Duodenum" name="PARAM_K_wat_cell_Lumen_Duodenum" formula="K_water_cell">
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       <Formula id="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_Caecum" name="PARAM_K_wat_cell_Lumen_Caecum" formula="K_water_cell">
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+      <Formula id="Lumen_PKSim.PARAM_K_cell_pls_ColonAscendens" name="PARAM_K_cell_pls_ColonAscendens" formula="K_cell_pls">
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+      <Formula id="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_ColonAscendens" name="PARAM_K_wat_cell_Lumen_ColonAscendens" formula="K_water_cell">
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+      <Formula id="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_ColonSigmoid" name="PARAM_K_wat_cell_Lumen_ColonSigmoid" formula="K_water_cell">
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+          <Path path="1104" as="1104" />
         </Paths>
       </DiscreteDistributionFormula>
-      <DiscreteDistributionFormula id="-ZC7xa8YO0-LrM2hIQWTfg">
+      <DiscreteDistributionFormula id="3PhfOgkoEk6tDVBNejszZg">
         <Paths>
-          <Path path="1118" as="1118" />
+          <Path path="1104" as="1104" />
         </Paths>
       </DiscreteDistributionFormula>
-      <NormalDistributionFormula id="fR1xpwc0_UG1nkGkKDynBQ" dim="Flow per weight organ">
+      <NormalDistributionFormula id="mE30cQQou0ehTsr3qIYNpg" dim="Flow per weight organ">
         <Paths>
-          <Path path="1118" as="1118" dim="159" />
-          <Path path="1119" as="1119" dim="159" />
+          <Path path="1104" as="1104" dim="159" />
+          <Path path="1105" as="1105" dim="159" />
         </Paths>
       </NormalDistributionFormula>
-      <NormalDistributionFormula id="Sj_SXL2x2kSPuh6sgGcRmQ" dim="Volume">
+      <NormalDistributionFormula id="ZhmUN9YmvEOt-HyHNfdPmw" dim="Volume">
         <Paths>
-          <Path path="1118" as="1118" dim="50" />
-          <Path path="1119" as="1119" dim="50" />
+          <Path path="1104" as="1104" dim="55" />
+          <Path path="1105" as="1105" dim="55" />
         </Paths>
       </NormalDistributionFormula>
-      <NormalDistributionFormula id="L3cPeTOAik6dlVn2AR1RuQ" dim="Flow per weight organ">
+      <NormalDistributionFormula id="125vTF3QxEaEaR-QZBT0Ug" dim="Flow per weight organ">
         <Paths>
-          <Path path="1118" as="1118" dim="159" />
-          <Path path="1119" as="1119" dim="159" />
+          <Path path="1104" as="1104" dim="159" />
+          <Path path="1105" as="1105" dim="159" />
         </Paths>
       </NormalDistributionFormula>
-      <NormalDistributionFormula id="yTUxSICrMUuYAzxdgpQQiw" dim="Volume">
+      <NormalDistributionFormula id="xPDrHgZyKEiRGR3jgamBqg" dim="Volume">
         <Paths>
-          <Path path="1118" as="1118" dim="50" />
-          <Path path="1119" as="1119" dim="50" />
+          <Path path="1104" as="1104" dim="55" />
+          <Path path="1105" as="1105" dim="55" />
         </Paths>
       </NormalDistributionFormula>
-      <NormalDistributionFormula id="ycX4GYvCPUGxkFfKNBGQkQ" dim="Volume">
+      <NormalDistributionFormula id="QeJ389wss0Kv4MNLc4Cnpw" dim="Volume">
         <Paths>
-          <Path path="1118" as="1118" dim="50" />
-          <Path path="1119" as="1119" dim="50" />
+          <Path path="1104" as="1104" dim="55" />
+          <Path path="1105" as="1105" dim="55" />
         </Paths>
       </NormalDistributionFormula>
-      <NormalDistributionFormula id="-QQoMLcJCkqsdSeTCYaAeQ" dim="Flow per weight organ">
+      <NormalDistributionFormula id="o9aYUNkx8EqIMiFXbVaSHA" dim="Flow per weight organ">
         <Paths>
-          <Path path="1118" as="1118" dim="159" />
-          <Path path="1119" as="1119" dim="159" />
+          <Path path="1104" as="1104" dim="159" />
+          <Path path="1105" as="1105" dim="159" />
         </Paths>
       </NormalDistributionFormula>
-      <LogNormalDistributionFormula id="gXr5JhMyeUGXpYZ0A_CgNA" dim="Volume">
+      <LogNormalDistributionFormula id="7vww41HCZUyxpdpfAa22kw" dim="Volume">
         <Paths>
-          <Path path="1118" as="1118" dim="50" />
-          <Path path="1120" as="1120" />
+          <Path path="1104" as="1104" dim="55" />
+          <Path path="1106" as="1106" />
         </Paths>
       </LogNormalDistributionFormula>
-      <NormalDistributionFormula id="S0a-n_zh2Uycl0P-y7j6Ug" dim="Flow per weight organ">
+      <NormalDistributionFormula id="uRTt_YKFwUSZB5BpJ7XGXw" dim="Flow per weight organ">
         <Paths>
-          <Path path="1118" as="1118" dim="159" />
-          <Path path="1119" as="1119" dim="159" />
+          <Path path="1104" as="1104" dim="159" />
+          <Path path="1105" as="1105" dim="159" />
         </Paths>
       </NormalDistributionFormula>
     </Formulas>
     <StringMap>
-      <Map s="..|Default Intestinal permeability (transcellular)" id="0" />
-      <Map s="P_int_trans_default" id="1" />
+      <Map s="MOLECULE|Calculated specific intestinal permeability (transcellular)" id="0" />
+      <Map s="P_int_InVitro" id="1" />
       <Map s="Velocity" id="2" />
-      <Map s="..|Intestinal permeability (transcellular)" id="3" />
-      <Map s="P_int_trans" id="4" />
-      <Map s="MOLECULE|P_bc_pls_factor" id="5" />
-      <Map s="P_rbc_pls_factor" id="6" />
-      <Map s="MOLECULE|Permeability" id="7" />
-      <Map s="P" id="8" />
-      <Map s="MOLECULE|Parameter b for correlation of intestinal permeability (transcellular)" id="9" />
-      <Map s="b" id="10" />
-      <Map s="MOLECULE|Parameter m for correlation of intestinal permeability (transcellular)" id="11" />
-      <Map s="m" id="12" />
-      <Map s="MOLECULE|Specific intestinal permeability (transcellular)" id="13" />
-      <Map s="P_int_InVitro" id="14" />
-      <Map s="MOLECULE|Calculated specific intestinal permeability (transcellular)" id="15" />
+      <Map s="MOLECULE|Parameter b for correlation of intestinal permeability (transcellular)" id="3" />
+      <Map s="b" id="4" />
+      <Map s="MOLECULE|Parameter m for correlation of intestinal permeability (transcellular)" id="5" />
+      <Map s="m" id="6" />
+      <Map s="MOLECULE|Specific intestinal permeability (transcellular)" id="7" />
+      <Map s="..|Default Intestinal permeability (transcellular)" id="8" />
+      <Map s="P_int_trans_default" id="9" />
+      <Map s="..|Intestinal permeability (transcellular)" id="10" />
+      <Map s="P_int_trans" id="11" />
+      <Map s="MOLECULE|P_bc_pls_factor" id="12" />
+      <Map s="P_rbc_pls_factor" id="13" />
+      <Map s="MOLECULE|Permeability" id="14" />
+      <Map s="P" id="15" />
       <Map s="MOLECULE|P_pls_bc_factor" id="16" />
       <Map s="P_pls_rbc_factor" id="17" />
       <Map s="..|BP_AGP" id="18" />
@@ -26991,72 +27060,72 @@
       <Map s="f_proteins_rbc" id="45" />
       <Map s="Organism|Vf (water,blood cells)" id="46" />
       <Map s="f_water_rbc" id="47" />
-      <Map s="Organism|ArterialBlood|Plasma|Volume" id="48" />
-      <Map s="V_pls_art" id="49" />
-      <Map s="Volume" id="50" />
-      <Map s="Organism|Bone|Plasma|Volume" id="51" />
-      <Map s="V_pls_bon" id="52" />
-      <Map s="Organism|Brain|Plasma|Volume" id="53" />
-      <Map s="V_pls_brn" id="54" />
-      <Map s="Organism|Fat|Plasma|Volume" id="55" />
-      <Map s="V_pls_fat" id="56" />
-      <Map s="Organism|Gonads|Plasma|Volume" id="57" />
-      <Map s="V_pls_tes" id="58" />
-      <Map s="Organism|Heart|Plasma|Volume" id="59" />
-      <Map s="V_pls_hrt" id="60" />
-      <Map s="Organism|Kidney|Plasma|Volume" id="61" />
-      <Map s="V_pls_kid" id="62" />
-      <Map s="Organism|LargeIntestine|Plasma|Volume" id="63" />
-      <Map s="V_pls_lin" id="64" />
-      <Map s="Organism|Lung|Plasma|Volume" id="65" />
-      <Map s="V_pls_lng" id="66" />
-      <Map s="Organism|Muscle|Plasma|Volume" id="67" />
-      <Map s="V_pls_mus" id="68" />
-      <Map s="Organism|Pancreas|Plasma|Volume" id="69" />
-      <Map s="V_pls_pan" id="70" />
-      <Map s="Organism|PortalVein|Plasma|Volume" id="71" />
-      <Map s="V_pls_pve" id="72" />
-      <Map s="Organism|Skin|Plasma|Volume" id="73" />
-      <Map s="V_pls_skn" id="74" />
-      <Map s="Organism|SmallIntestine|Plasma|Volume" id="75" />
-      <Map s="V_pls_sin" id="76" />
-      <Map s="Organism|Spleen|Plasma|Volume" id="77" />
-      <Map s="V_pls_spl" id="78" />
-      <Map s="Organism|Stomach|Plasma|Volume" id="79" />
-      <Map s="V_pls_sto" id="80" />
-      <Map s="Organism|VenousBlood|Plasma|Volume" id="81" />
-      <Map s="V_pls_ven" id="82" />
-      <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Plasma|Volume" id="83" />
-      <Map s="V_pls_duo" id="84" />
-      <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Plasma|Volume" id="85" />
-      <Map s="V_pls_uje" id="86" />
-      <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Plasma|Volume" id="87" />
-      <Map s="V_pls_lje" id="88" />
-      <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Plasma|Volume" id="89" />
-      <Map s="V_pls_uil" id="90" />
-      <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Plasma|Volume" id="91" />
-      <Map s="V_pls_lil" id="92" />
-      <Map s="Organism|LargeIntestine|Mucosa|Caecum|Plasma|Volume" id="93" />
-      <Map s="V_pls_cae" id="94" />
-      <Map s="Organism|LargeIntestine|Mucosa|ColonAscendens|Plasma|Volume" id="95" />
-      <Map s="V_pls_colasc" id="96" />
-      <Map s="Organism|LargeIntestine|Mucosa|ColonTransversum|Plasma|Volume" id="97" />
-      <Map s="V_pls_coltrans" id="98" />
-      <Map s="Organism|LargeIntestine|Mucosa|ColonDescendens|Plasma|Volume" id="99" />
-      <Map s="V_pls_coldesc" id="100" />
-      <Map s="Organism|LargeIntestine|Mucosa|ColonSigmoid|Plasma|Volume" id="101" />
-      <Map s="V_pls_colsigm" id="102" />
-      <Map s="Organism|LargeIntestine|Mucosa|Rectum|Plasma|Volume" id="103" />
-      <Map s="V_pls_rect" id="104" />
-      <Map s="Organism|Liver|Periportal|Plasma|Volume" id="105" />
-      <Map s="V_pls_prp" id="106" />
-      <Map s="Organism|Liver|Pericentral|Plasma|Volume" id="107" />
-      <Map s="V_pls_prc" id="108" />
-      <Map s="Organism|Rate constant for endosomal uptake (global)" id="109" />
-      <Map s="K_uptake" id="110" />
-      <Map s="Inversed time" id="111" />
-      <Map s="Organism|Rate constant for recycling from endosomal space (global)" id="112" />
-      <Map s="K_rec" id="113" />
+      <Map s="Organism|Rate constant for endosomal uptake (global)" id="48" />
+      <Map s="K_uptake" id="49" />
+      <Map s="Inversed time" id="50" />
+      <Map s="Organism|Rate constant for recycling from endosomal space (global)" id="51" />
+      <Map s="K_rec" id="52" />
+      <Map s="Organism|ArterialBlood|Plasma|Volume" id="53" />
+      <Map s="V_pls_art" id="54" />
+      <Map s="Volume" id="55" />
+      <Map s="Organism|Bone|Plasma|Volume" id="56" />
+      <Map s="V_pls_bon" id="57" />
+      <Map s="Organism|Brain|Plasma|Volume" id="58" />
+      <Map s="V_pls_brn" id="59" />
+      <Map s="Organism|Fat|Plasma|Volume" id="60" />
+      <Map s="V_pls_fat" id="61" />
+      <Map s="Organism|Gonads|Plasma|Volume" id="62" />
+      <Map s="V_pls_tes" id="63" />
+      <Map s="Organism|Heart|Plasma|Volume" id="64" />
+      <Map s="V_pls_hrt" id="65" />
+      <Map s="Organism|Kidney|Plasma|Volume" id="66" />
+      <Map s="V_pls_kid" id="67" />
+      <Map s="Organism|LargeIntestine|Plasma|Volume" id="68" />
+      <Map s="V_pls_lin" id="69" />
+      <Map s="Organism|Lung|Plasma|Volume" id="70" />
+      <Map s="V_pls_lng" id="71" />
+      <Map s="Organism|Muscle|Plasma|Volume" id="72" />
+      <Map s="V_pls_mus" id="73" />
+      <Map s="Organism|Pancreas|Plasma|Volume" id="74" />
+      <Map s="V_pls_pan" id="75" />
+      <Map s="Organism|PortalVein|Plasma|Volume" id="76" />
+      <Map s="V_pls_pve" id="77" />
+      <Map s="Organism|Skin|Plasma|Volume" id="78" />
+      <Map s="V_pls_skn" id="79" />
+      <Map s="Organism|SmallIntestine|Plasma|Volume" id="80" />
+      <Map s="V_pls_sin" id="81" />
+      <Map s="Organism|Spleen|Plasma|Volume" id="82" />
+      <Map s="V_pls_spl" id="83" />
+      <Map s="Organism|Stomach|Plasma|Volume" id="84" />
+      <Map s="V_pls_sto" id="85" />
+      <Map s="Organism|VenousBlood|Plasma|Volume" id="86" />
+      <Map s="V_pls_ven" id="87" />
+      <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Plasma|Volume" id="88" />
+      <Map s="V_pls_duo" id="89" />
+      <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Plasma|Volume" id="90" />
+      <Map s="V_pls_uje" id="91" />
+      <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Plasma|Volume" id="92" />
+      <Map s="V_pls_lje" id="93" />
+      <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Plasma|Volume" id="94" />
+      <Map s="V_pls_uil" id="95" />
+      <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Plasma|Volume" id="96" />
+      <Map s="V_pls_lil" id="97" />
+      <Map s="Organism|LargeIntestine|Mucosa|Caecum|Plasma|Volume" id="98" />
+      <Map s="V_pls_cae" id="99" />
+      <Map s="Organism|LargeIntestine|Mucosa|ColonAscendens|Plasma|Volume" id="100" />
+      <Map s="V_pls_colasc" id="101" />
+      <Map s="Organism|LargeIntestine|Mucosa|ColonTransversum|Plasma|Volume" id="102" />
+      <Map s="V_pls_coltrans" id="103" />
+      <Map s="Organism|LargeIntestine|Mucosa|ColonDescendens|Plasma|Volume" id="104" />
+      <Map s="V_pls_coldesc" id="105" />
+      <Map s="Organism|LargeIntestine|Mucosa|ColonSigmoid|Plasma|Volume" id="106" />
+      <Map s="V_pls_colsigm" id="107" />
+      <Map s="Organism|LargeIntestine|Mucosa|Rectum|Plasma|Volume" id="108" />
+      <Map s="V_pls_rect" id="109" />
+      <Map s="Organism|Liver|Periportal|Plasma|Volume" id="110" />
+      <Map s="V_pls_prp" id="111" />
+      <Map s="Organism|Liver|Pericentral|Plasma|Volume" id="112" />
+      <Map s="V_pls_prc" id="113" />
       <Map s="Organism|Weight of blood organs" id="114" />
       <Map s="Weight_blood" id="115" />
       <Map s="Mass" id="116" />
@@ -27096,10 +27165,10 @@
       <Map s="f_uptake_vas_global" id="150" />
       <Map s="Organism|Fraction endosomal (global)" id="151" />
       <Map s="f_endo_global" id="152" />
-      <Map s="Rrec_global" id="153" />
-      <Map s="Rendo_v_global" id="154" />
-      <Map s="Organism|Fraction recycled to plasma (global)" id="155" />
-      <Map s="f_rec_vas_global" id="156" />
+      <Map s="Organism|Fraction recycled to plasma (global)" id="153" />
+      <Map s="f_rec_vas_global" id="154" />
+      <Map s="Rendo_v_global" id="155" />
+      <Map s="Rrec_global" id="156" />
       <Map s="..|Specific blood flow rate" id="157" />
       <Map s="Qspec" id="158" />
       <Map s="Flow per weight organ" id="159" />
@@ -27160,32 +27229,32 @@
       <Map s="Neighborhoods|Heart_int_Heart_cell|MOLECULE|Partition coefficient (interstitial/water)" id="214" />
       <Map s="Neighborhoods|Heart_int_Heart_cell|MOLECULE|Partition coefficient (intracellular/water)" id="215" />
       <Map s="Neighborhoods|Kidney_pls_Kidney_int|Surface area (plasma/interstitial)" id="216" />
-      <Map s="Organism|Age" id="217" />
-      <Map s="Organism|Kidney|Age of aging onset" id="218" />
-      <Map s="Age_onset" id="219" />
-      <Map s="Organism|Kidney|Aging half-time" id="220" />
-      <Map s="TA50" id="221" />
-      <Map s="Organism|Kidney|Hill coefficient for aging GFR" id="222" />
-      <Map s="Hill" id="223" />
-      <Map s="Organism|Kidney|Maximal decreasing rate factor" id="224" />
-      <Map s="Decrease_Factor" id="225" />
-      <Map s="Organism|Kidney|GFR (specific)" id="226" />
-      <Map s="GFRspec" id="227" />
-      <Map s="Organism|Kidney|Weight (tissue)" id="228" />
-      <Map s="Weight_Kidney" id="229" />
-      <Map s="Organism|Estimated gestational age" id="230" />
-      <Map s="PMA" id="231" />
-      <Map s="Organism|Kidney|fGFRpremat" id="232" />
-      <Map s="GFR_premat" id="233" />
-      <Map s="Organism|Kidney|GFRmat" id="234" />
-      <Map s="GFR_mat" id="235" />
-      <Map s="Organism|Kidney|Hill coefficient for GFR" id="236" />
-      <Map s="Organism|Kidney|Renal aging scaling factor" id="237" />
-      <Map s="Renal_aging_scaling_factor" id="238" />
-      <Map s="Organism|Kidney|TM50 for GFR" id="239" />
-      <Map s="TM50" id="240" />
-      <Map s="Organism|Kidney|Volume (standard kidney)" id="241" />
-      <Map s="V_kid_std" id="242" />
+      <Map s="Organism|Kidney|GFR (specific)" id="217" />
+      <Map s="GFRspec" id="218" />
+      <Map s="Organism|Kidney|Weight (tissue)" id="219" />
+      <Map s="Weight_Kidney" id="220" />
+      <Map s="Organism|Estimated gestational age" id="221" />
+      <Map s="PMA" id="222" />
+      <Map s="Organism|Kidney|GFRmat" id="223" />
+      <Map s="GFR_mat" id="224" />
+      <Map s="Organism|Kidney|Hill coefficient for GFR" id="225" />
+      <Map s="Hill" id="226" />
+      <Map s="Organism|Kidney|Renal aging scaling factor" id="227" />
+      <Map s="Renal_aging_scaling_factor" id="228" />
+      <Map s="Organism|Kidney|TM50 for GFR" id="229" />
+      <Map s="TM50" id="230" />
+      <Map s="Organism|Kidney|Volume (standard kidney)" id="231" />
+      <Map s="V_kid_std" id="232" />
+      <Map s="Organism|Kidney|fGFRpremat" id="233" />
+      <Map s="GFR_premat" id="234" />
+      <Map s="Organism|Age" id="235" />
+      <Map s="Organism|Kidney|Age of aging onset" id="236" />
+      <Map s="Age_onset" id="237" />
+      <Map s="Organism|Kidney|Aging half-time" id="238" />
+      <Map s="TA50" id="239" />
+      <Map s="Organism|Kidney|Hill coefficient for aging GFR" id="240" />
+      <Map s="Organism|Kidney|Maximal decreasing rate factor" id="241" />
+      <Map s="Decrease_Factor" id="242" />
       <Map s="Neighborhoods|Kidney_int_Kidney_cell|MOLECULE|Partition coefficient (interstitial/water)" id="243" />
       <Map s="Neighborhoods|Kidney_int_Kidney_cell|MOLECULE|Partition coefficient (intracellular/water)" id="244" />
       <Map s="..|Fraction of geometric volume filled with liquid" id="245" />
@@ -27214,36 +27283,36 @@
       <Map s="w" id="268" />
       <Map s="..|..|Duodenum|FillLevelFlag" id="269" />
       <Map s="FillLevelFlagNext" id="270" />
-      <Map s="..|Inverse rate of inflow of liquid into stomach" id="271" />
-      <Map s="StomachInflowTime" id="272" />
-      <Map s="..|Geometric surface area" id="273" />
-      <Map s="..|Thickness of gut wall" id="274" />
-      <Map s="d" id="275" />
-      <Map s="..|pH in fasted state" id="276" />
-      <Map s="pH_fasted" id="277" />
-      <Map s="..|pKa_pH_WS_lum_F1" id="278" />
-      <Map s="F1" id="279" />
-      <Map s="..|pKa_pH_WS_lum_F2" id="280" />
-      <Map s="F2" id="281" />
-      <Map s="..|pKa_pH_WS_lum_F3" id="282" />
-      <Map s="F3" id="283" />
-      <Map s="MOLECULE|Ontogeny factor GI" id="284" />
-      <Map s="MOLECULE|Compound type 0" id="285" />
-      <Map s="CT0" id="286" />
-      <Map s="MOLECULE|CT_NEUTRAL" id="287" />
-      <Map s="CT_NEUTRAL" id="288" />
-      <Map s="MOLECULE|pKa value 0" id="289" />
-      <Map s="pKa_0" id="290" />
-      <Map s="..|..|pH" id="291" />
-      <Map s="pH" id="292" />
-      <Map s="MOLECULE|Compound type 1" id="293" />
-      <Map s="CT1" id="294" />
-      <Map s="MOLECULE|pKa value 1" id="295" />
-      <Map s="pKa_1" id="296" />
-      <Map s="MOLECULE|Compound type 2" id="297" />
-      <Map s="CT2" id="298" />
-      <Map s="MOLECULE|pKa value 2" id="299" />
-      <Map s="pKa_2" id="300" />
+      <Map s="..|pH in fasted state" id="271" />
+      <Map s="pH_fasted" id="272" />
+      <Map s="..|Inverse rate of inflow of liquid into stomach" id="273" />
+      <Map s="StomachInflowTime" id="274" />
+      <Map s="..|Geometric surface area" id="275" />
+      <Map s="..|Thickness of gut wall" id="276" />
+      <Map s="d" id="277" />
+      <Map s="MOLECULE|Ontogeny factor GI" id="278" />
+      <Map s="MOLECULE|CT_NEUTRAL" id="279" />
+      <Map s="CT_NEUTRAL" id="280" />
+      <Map s="MOLECULE|Compound type 0" id="281" />
+      <Map s="CT0" id="282" />
+      <Map s="MOLECULE|pKa value 0" id="283" />
+      <Map s="pKa_0" id="284" />
+      <Map s="..|..|pH" id="285" />
+      <Map s="pH" id="286" />
+      <Map s="MOLECULE|Compound type 1" id="287" />
+      <Map s="CT1" id="288" />
+      <Map s="MOLECULE|pKa value 1" id="289" />
+      <Map s="pKa_1" id="290" />
+      <Map s="MOLECULE|Compound type 2" id="291" />
+      <Map s="CT2" id="292" />
+      <Map s="MOLECULE|pKa value 2" id="293" />
+      <Map s="pKa_2" id="294" />
+      <Map s="..|pKa_pH_WS_lum_F1" id="295" />
+      <Map s="F1" id="296" />
+      <Map s="..|pKa_pH_WS_lum_F2" id="297" />
+      <Map s="F2" id="298" />
+      <Map s="..|pKa_pH_WS_lum_F3" id="299" />
+      <Map s="F3" id="300" />
       <Map s="..|Solubility table" id="301" />
       <Map s="SolubilityTable" id="302" />
       <Map s="Concentration (mass)" id="303" />
@@ -27275,795 +27344,781 @@
       <Map s="MOLECULE|Solubility gain per charge" id="329" />
       <Map s="base" id="330" />
       <Map s="MOLECULE|t1/2 (intestine)" id="331" />
-      <Map s="..|Intestinal transit rate" id="332" />
-      <Map s="LuminalVelocity" id="333" />
-      <Map s="Organism|SmallIntestine|Small intestinal transit time factor" id="334" />
-      <Map s="SITT_fact" id="335" />
-      <Map s="..|..|..|Height" id="336" />
-      <Map s="..|L_p0" id="337" />
-      <Map s="L_p0" id="338" />
-      <Map s="..|L_p1" id="339" />
-      <Map s="L_p1" id="340" />
-      <Map s="..|Absorption of liquid" id="341" />
-      <Map s="Outflow" id="342" />
-      <Map s="LT_duo" id="343" />
-      <Map s="..|..|Stomach|Liquid transfer rate" id="344" />
-      <Map s="..|..|UpperJejunum|FillLevelFlag" id="345" />
-      <Map s="..|r1_p0" id="346" />
-      <Map s="r1_p0" id="347" />
-      <Map s="..|r1_p1" id="348" />
-      <Map s="r1_p1" id="349" />
-      <Map s="..|Thickness_p1" id="350" />
-      <Map s="Thickness_p1" id="351" />
-      <Map s="..|Thickness_p2" id="352" />
-      <Map s="Thickness_p2" id="353" />
-      <Map s="..|Thickness_p3" id="354" />
-      <Map s="Thickness_p3" id="355" />
-      <Map s="Inversed length" id="356" />
-      <Map s="Organism|SmallIntestine|Volume" id="357" />
-      <Map s="V_Intestine" id="358" />
-      <Map s="alpha" id="359" />
-      <Map s="k" id="360" />
-      <Map s="inflow" id="361" />
-      <Map s="..|..|Stomach|Fractional steady state fill level" id="362" />
-      <Map s="alpha_p" id="363" />
-      <Map s="..|..|Stomach|Intestinal transit rate (absolute)" id="364" />
-      <Map s="k_p" id="365" />
-      <Map s="..|..|Stomach|Volume" id="366" />
-      <Map s="V_p" id="367" />
-      <Map s="..|r2_p0" id="368" />
-      <Map s="r2_p0" id="369" />
-      <Map s="..|r2_p1" id="370" />
-      <Map s="r2_p1" id="371" />
-      <Map s="..|Effective surface area enhancement factor" id="372" />
-      <Map s="AeffFactor" id="373" />
-      <Map s="Ageom" id="374" />
-      <Map s="Organism|Lumen|Effective surface area variability factor" id="375" />
-      <Map s="AeffVariabilityFactor" id="376" />
-      <Map s="Neighborhoods|Lumen_duo_Duodenum_pls|MOLECULE|Sum of active process rates" id="377" />
-      <Map s="ActiveRates_para" id="378" />
-      <Map s="Amount per time" id="379" />
-      <Map s="Neighborhoods|Lumen_duo_Duodenum_cell|MOLECULE|Sum of active process rates" id="380" />
-      <Map s="ActiveRates_trans" id="381" />
-      <Map s="Neighborhoods|Lumen_duo_Duodenum_pls|MOLECULE|Sum of passive process rates" id="382" />
-      <Map s="PassiveRates_para" id="383" />
-      <Map s="Neighborhoods|Lumen_duo_Duodenum_cell|MOLECULE|Sum of passive process rates" id="384" />
-      <Map s="PassiveRates_trans" id="385" />
-      <Map s="LT_uje" id="386" />
-      <Map s="..|..|Duodenum|Liquid transfer rate" id="387" />
-      <Map s="..|..|LowerJejunum|FillLevelFlag" id="388" />
-      <Map s="..|..|Duodenum|Fractional steady state fill level" id="389" />
-      <Map s="..|..|Duodenum|Intestinal transit rate (absolute)" id="390" />
-      <Map s="..|..|Duodenum|Volume" id="391" />
-      <Map s="Neighborhoods|Lumen_uje_UpperJejunum_pls|MOLECULE|Sum of active process rates" id="392" />
-      <Map s="Neighborhoods|Lumen_uje_UpperJejunum_cell|MOLECULE|Sum of active process rates" id="393" />
-      <Map s="Neighborhoods|Lumen_uje_UpperJejunum_pls|MOLECULE|Sum of passive process rates" id="394" />
-      <Map s="Neighborhoods|Lumen_uje_UpperJejunum_cell|MOLECULE|Sum of passive process rates" id="395" />
-      <Map s="..|..|UpperIleum|FillLevelFlag" id="396" />
-      <Map s="LT_lje" id="397" />
-      <Map s="..|..|UpperJejunum|Liquid transfer rate" id="398" />
-      <Map s="..|..|UpperJejunum|Fractional steady state fill level" id="399" />
-      <Map s="..|..|UpperJejunum|Intestinal transit rate (absolute)" id="400" />
-      <Map s="..|..|UpperJejunum|Volume" id="401" />
-      <Map s="Neighborhoods|Lumen_lje_LowerJejunum_pls|MOLECULE|Sum of active process rates" id="402" />
-      <Map s="Neighborhoods|Lumen_lje_LowerJejunum_cell|MOLECULE|Sum of active process rates" id="403" />
-      <Map s="Neighborhoods|Lumen_lje_LowerJejunum_pls|MOLECULE|Sum of passive process rates" id="404" />
-      <Map s="Neighborhoods|Lumen_lje_LowerJejunum_cell|MOLECULE|Sum of passive process rates" id="405" />
-      <Map s="..|..|LowerJejunum|Fractional steady state fill level" id="406" />
-      <Map s="..|..|LowerJejunum|Intestinal transit rate (absolute)" id="407" />
-      <Map s="..|..|LowerJejunum|Volume" id="408" />
-      <Map s="LT_uil" id="409" />
-      <Map s="..|..|LowerJejunum|Liquid transfer rate" id="410" />
-      <Map s="..|..|LowerIleum|FillLevelFlag" id="411" />
-      <Map s="Neighborhoods|Lumen_uil_UpperIleum_pls|MOLECULE|Sum of active process rates" id="412" />
-      <Map s="Neighborhoods|Lumen_uil_UpperIleum_cell|MOLECULE|Sum of active process rates" id="413" />
-      <Map s="Neighborhoods|Lumen_uil_UpperIleum_pls|MOLECULE|Sum of passive process rates" id="414" />
-      <Map s="Neighborhoods|Lumen_uil_UpperIleum_cell|MOLECULE|Sum of passive process rates" id="415" />
-      <Map s="..|..|UpperIleum|Fractional steady state fill level" id="416" />
-      <Map s="..|..|UpperIleum|Intestinal transit rate (absolute)" id="417" />
-      <Map s="..|..|UpperIleum|Volume" id="418" />
-      <Map s="LT_lil" id="419" />
-      <Map s="..|..|UpperIleum|Liquid transfer rate" id="420" />
-      <Map s="..|..|Caecum|FillLevelFlag" id="421" />
-      <Map s="Neighborhoods|Lumen_lil_LowerIleum_pls|MOLECULE|Sum of active process rates" id="422" />
-      <Map s="Neighborhoods|Lumen_lil_LowerIleum_cell|MOLECULE|Sum of active process rates" id="423" />
-      <Map s="Neighborhoods|Lumen_lil_LowerIleum_pls|MOLECULE|Sum of passive process rates" id="424" />
-      <Map s="Neighborhoods|Lumen_lil_LowerIleum_cell|MOLECULE|Sum of passive process rates" id="425" />
-      <Map s="Organism|LargeIntestine|Volume" id="426" />
-      <Map s="Organism|LargeIntestine|Large intestinal transit time factor" id="427" />
-      <Map s="LITT_fact" id="428" />
-      <Map s="..|..|LowerIleum|Fractional steady state fill level" id="429" />
-      <Map s="..|..|LowerIleum|Intestinal transit rate (absolute)" id="430" />
-      <Map s="..|..|LowerIleum|Volume" id="431" />
-      <Map s="LT_cae" id="432" />
-      <Map s="..|..|LowerIleum|Liquid transfer rate" id="433" />
-      <Map s="..|..|ColonAscendens|FillLevelFlag" id="434" />
-      <Map s="Neighborhoods|Lumen_cae_Caecum_pls|MOLECULE|Sum of active process rates" id="435" />
-      <Map s="Neighborhoods|Lumen_cae_Caecum_cell|MOLECULE|Sum of active process rates" id="436" />
-      <Map s="Neighborhoods|Lumen_cae_Caecum_pls|MOLECULE|Sum of passive process rates" id="437" />
-      <Map s="Neighborhoods|Lumen_cae_Caecum_cell|MOLECULE|Sum of passive process rates" id="438" />
-      <Map s="LT_colasc" id="439" />
-      <Map s="..|..|Caecum|Liquid transfer rate" id="440" />
-      <Map s="..|..|Caecum|Fractional steady state fill level" id="441" />
-      <Map s="..|..|Caecum|Intestinal transit rate (absolute)" id="442" />
-      <Map s="..|..|Caecum|Volume" id="443" />
-      <Map s="..|..|ColonTransversum|FillLevelFlag" id="444" />
-      <Map s="Neighborhoods|Lumen_colasc_ColonAscendens_pls|MOLECULE|Sum of active process rates" id="445" />
-      <Map s="Neighborhoods|Lumen_colasc_ColonAscendens_cell|MOLECULE|Sum of active process rates" id="446" />
-      <Map s="Neighborhoods|Lumen_colasc_ColonAscendens_pls|MOLECULE|Sum of passive process rates" id="447" />
-      <Map s="Neighborhoods|Lumen_colasc_ColonAscendens_cell|MOLECULE|Sum of passive process rates" id="448" />
-      <Map s="..|..|ColonDescendens|FillLevelFlag" id="449" />
-      <Map s="LT_coltrans" id="450" />
-      <Map s="..|..|ColonAscendens|Liquid transfer rate" id="451" />
-      <Map s="..|..|ColonAscendens|Fractional steady state fill level" id="452" />
-      <Map s="..|..|ColonAscendens|Intestinal transit rate (absolute)" id="453" />
-      <Map s="..|..|ColonAscendens|Volume" id="454" />
-      <Map s="Neighborhoods|Lumen_coltrans_ColonTransversum_pls|MOLECULE|Sum of active process rates" id="455" />
-      <Map s="Neighborhoods|Lumen_coltrans_ColonTransversum_cell|MOLECULE|Sum of active process rates" id="456" />
-      <Map s="Neighborhoods|Lumen_coltrans_ColonTransversum_pls|MOLECULE|Sum of passive process rates" id="457" />
-      <Map s="Neighborhoods|Lumen_coltrans_ColonTransversum_cell|MOLECULE|Sum of passive process rates" id="458" />
-      <Map s="..|..|ColonTransversum|Fractional steady state fill level" id="459" />
-      <Map s="..|..|ColonTransversum|Intestinal transit rate (absolute)" id="460" />
-      <Map s="..|..|ColonTransversum|Volume" id="461" />
-      <Map s="LT_coldesc" id="462" />
-      <Map s="..|..|ColonTransversum|Liquid transfer rate" id="463" />
-      <Map s="..|..|ColonSigmoid|FillLevelFlag" id="464" />
-      <Map s="Neighborhoods|Lumen_coldesc_ColonDescendens_pls|MOLECULE|Sum of active process rates" id="465" />
-      <Map s="Neighborhoods|Lumen_coldesc_ColonDescendens_cell|MOLECULE|Sum of active process rates" id="466" />
-      <Map s="Neighborhoods|Lumen_coldesc_ColonDescendens_pls|MOLECULE|Sum of passive process rates" id="467" />
-      <Map s="Neighborhoods|Lumen_coldesc_ColonDescendens_cell|MOLECULE|Sum of passive process rates" id="468" />
-      <Map s="LT_colsigm" id="469" />
-      <Map s="..|..|ColonDescendens|Liquid transfer rate" id="470" />
-      <Map s="..|..|Rectum|FillLevelFlag" id="471" />
-      <Map s="..|..|ColonDescendens|Fractional steady state fill level" id="472" />
-      <Map s="..|..|ColonDescendens|Intestinal transit rate (absolute)" id="473" />
-      <Map s="..|..|ColonDescendens|Volume" id="474" />
-      <Map s="Neighborhoods|Lumen_colsigm_ColonSigmoid_pls|MOLECULE|Sum of active process rates" id="475" />
-      <Map s="Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|MOLECULE|Sum of active process rates" id="476" />
-      <Map s="Neighborhoods|Lumen_colsigm_ColonSigmoid_pls|MOLECULE|Sum of passive process rates" id="477" />
-      <Map s="Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|MOLECULE|Sum of passive process rates" id="478" />
-      <Map s="..|..|ColonSigmoid|Fractional steady state fill level" id="479" />
-      <Map s="..|..|ColonSigmoid|Intestinal transit rate (absolute)" id="480" />
-      <Map s="..|..|ColonSigmoid|Volume" id="481" />
-      <Map s="LT_rect" id="482" />
-      <Map s="..|..|ColonSigmoid|Liquid transfer rate" id="483" />
-      <Map s="Neighborhoods|Lumen_rect_Rectum_pls|MOLECULE|Sum of active process rates" id="484" />
-      <Map s="Neighborhoods|Lumen_rect_Rectum_cell|MOLECULE|Sum of active process rates" id="485" />
-      <Map s="Neighborhoods|Lumen_rect_Rectum_pls|MOLECULE|Sum of passive process rates" id="486" />
-      <Map s="Neighborhoods|Lumen_rect_Rectum_cell|MOLECULE|Sum of passive process rates" id="487" />
-      <Map s="..|..|Rectum|Liquid transfer rate" id="488" />
-      <Map s="LT_rec" id="489" />
-      <Map s="Neighborhoods|Stomach_pls_Stomach_int|Surface area (plasma/interstitial)" id="490" />
-      <Map s="Neighborhoods|Stomach_int_Stomach_cell|MOLECULE|Partition coefficient (interstitial/water)" id="491" />
-      <Map s="Neighborhoods|Stomach_int_Stomach_cell|MOLECULE|Partition coefficient (intracellular/water)" id="492" />
-      <Map s="..|Small intestinal transit time" id="493" />
-      <Map s="SITT" id="494" />
-      <Map s="..|Small intestinal transit time factor intercept" id="495" />
-      <Map s="P2" id="496" />
-      <Map s="..|Small intestinal transit time factor slope" id="497" />
-      <Map s="P1" id="498" />
-      <Map s="..|Fluid recirculation flow rate (incl. mucosa)" id="499" />
-      <Map s="J_iso_incl_Mucosa" id="500" />
-      <Map s="..|Mucosa|Duodenum|Fluid recirculation flow rate" id="501" />
-      <Map s="J_iso_duo" id="502" />
-      <Map s="..|Mucosa|LowerIleum|Fluid recirculation flow rate" id="503" />
-      <Map s="J_iso_lil" id="504" />
-      <Map s="..|Mucosa|LowerJejunum|Fluid recirculation flow rate" id="505" />
-      <Map s="J_iso_lje" id="506" />
-      <Map s="..|Mucosa|UpperIleum|Fluid recirculation flow rate" id="507" />
-      <Map s="J_iso_uil" id="508" />
-      <Map s="..|Mucosa|UpperJejunum|Fluid recirculation flow rate" id="509" />
-      <Map s="J_iso_uje" id="510" />
-      <Map s="Neighborhoods|SmallIntestine_pls_SmallIntestine_int|Surface area (plasma/interstitial)" id="511" />
-      <Map s="..|Lymph flow rate (incl. mucosa)" id="512" />
-      <Map s="Q_lymph_incl_Mucosa" id="513" />
-      <Map s="..|Mucosa|Duodenum|Lymph flow rate" id="514" />
-      <Map s="Q_lymph_duo" id="515" />
-      <Map s="..|Mucosa|LowerIleum|Lymph flow rate" id="516" />
-      <Map s="Q_lymph_lil" id="517" />
-      <Map s="..|Mucosa|LowerJejunum|Lymph flow rate" id="518" />
-      <Map s="Q_lymph_lje" id="519" />
-      <Map s="..|Mucosa|UpperIleum|Lymph flow rate" id="520" />
-      <Map s="Q_lymph_uil" id="521" />
-      <Map s="..|Mucosa|UpperJejunum|Lymph flow rate" id="522" />
-      <Map s="Q_lymph_uje" id="523" />
-      <Map s="..|Mucosa|Duodenum|Volume" id="524" />
-      <Map s="V_duo" id="525" />
-      <Map s="..|Mucosa|LowerIleum|Volume" id="526" />
-      <Map s="V_lil" id="527" />
-      <Map s="..|Mucosa|LowerJejunum|Volume" id="528" />
-      <Map s="V_lje" id="529" />
-      <Map s="..|Mucosa|UpperIleum|Volume" id="530" />
-      <Map s="V_uil" id="531" />
-      <Map s="..|Mucosa|UpperJejunum|Volume" id="532" />
-      <Map s="V_uje" id="533" />
-      <Map s="..|..|Volume (mucosa)" id="534" />
-      <Map s="V_Mucosa" id="535" />
-      <Map s="Neighborhoods|SmallIntestine_int_SmallIntestine_cell|MOLECULE|Partition coefficient (interstitial/water)" id="536" />
-      <Map s="Neighborhoods|SmallIntestine_int_SmallIntestine_cell|MOLECULE|Partition coefficient (intracellular/water)" id="537" />
-      <Map s="..|Fraction mucosa" id="538" />
-      <Map s="fractionMucosa" id="539" />
-      <Map s="..|..|..|..|Lumen|Duodenum|Volume (gut wall)" id="540" />
-      <Map s="V_GutWall" id="541" />
-      <Map s="..|..|..|Lymph flow rate (incl. mucosa)" id="542" />
-      <Map s="Q_lymph_intestine" id="543" />
-      <Map s="..|..|..|Volume" id="544" />
-      <Map s="V_intestine" id="545" />
-      <Map s="V_seg" id="546" />
-      <Map s="Neighborhoods|Duodenum_pls_Duodenum_int|Surface area (plasma/interstitial)" id="547" />
-      <Map s="..|..|..|Fluid recirculation flow rate (incl. mucosa)" id="548" />
-      <Map s="J_iso_intestine" id="549" />
-      <Map s="..|..|..|Blood flow rate" id="550" />
-      <Map s="..|Fraction of regional blood flow rate" id="551" />
-      <Map s="regionalFractQ" id="552" />
-      <Map s="..|..|..|Mucosa blood flow fraction" id="553" />
-      <Map s="fractQ" id="554" />
-      <Map s="Neighborhoods|Duodenum_int_Duodenum_cell|MOLECULE|Partition coefficient (interstitial/water)" id="555" />
-      <Map s="Neighborhoods|Duodenum_int_Duodenum_cell|MOLECULE|Partition coefficient (intracellular/water)" id="556" />
-      <Map s="..|..|..|..|Lumen|UpperJejunum|Volume (gut wall)" id="557" />
-      <Map s="Neighborhoods|UpperJejunum_pls_UpperJejunum_int|Surface area (plasma/interstitial)" id="558" />
-      <Map s="Neighborhoods|UpperJejunum_int_UpperJejunum_cell|MOLECULE|Partition coefficient (interstitial/water)" id="559" />
-      <Map s="Neighborhoods|UpperJejunum_int_UpperJejunum_cell|MOLECULE|Partition coefficient (intracellular/water)" id="560" />
-      <Map s="..|..|..|..|Lumen|LowerJejunum|Volume (gut wall)" id="561" />
-      <Map s="Neighborhoods|LowerJejunum_pls_LowerJejunum_int|Surface area (plasma/interstitial)" id="562" />
-      <Map s="Neighborhoods|LowerJejunum_int_LowerJejunum_cell|MOLECULE|Partition coefficient (interstitial/water)" id="563" />
-      <Map s="Neighborhoods|LowerJejunum_int_LowerJejunum_cell|MOLECULE|Partition coefficient (intracellular/water)" id="564" />
-      <Map s="..|..|..|..|Lumen|UpperIleum|Volume (gut wall)" id="565" />
-      <Map s="Neighborhoods|UpperIleum_pls_UpperIleum_int|Surface area (plasma/interstitial)" id="566" />
-      <Map s="Neighborhoods|UpperIleum_int_UpperIleum_cell|MOLECULE|Partition coefficient (interstitial/water)" id="567" />
-      <Map s="Neighborhoods|UpperIleum_int_UpperIleum_cell|MOLECULE|Partition coefficient (intracellular/water)" id="568" />
-      <Map s="..|..|..|..|Lumen|LowerIleum|Volume (gut wall)" id="569" />
-      <Map s="Neighborhoods|LowerIleum_pls_LowerIleum_int|Surface area (plasma/interstitial)" id="570" />
-      <Map s="Neighborhoods|LowerIleum_int_LowerIleum_cell|MOLECULE|Partition coefficient (interstitial/water)" id="571" />
-      <Map s="Neighborhoods|LowerIleum_int_LowerIleum_cell|MOLECULE|Partition coefficient (intracellular/water)" id="572" />
-      <Map s="..|Mucosa|Caecum|Volume" id="573" />
-      <Map s="V_cae" id="574" />
-      <Map s="..|Mucosa|ColonAscendens|Volume" id="575" />
-      <Map s="V_ca" id="576" />
-      <Map s="..|Mucosa|ColonDescendens|Volume" id="577" />
-      <Map s="V_cd" id="578" />
-      <Map s="..|Mucosa|ColonSigmoid|Volume" id="579" />
-      <Map s="V_cs" id="580" />
-      <Map s="..|Mucosa|ColonTransversum|Volume" id="581" />
-      <Map s="V_ct" id="582" />
-      <Map s="..|Mucosa|Rectum|Volume" id="583" />
-      <Map s="V_rec" id="584" />
-      <Map s="..|Large intestinal transit time" id="585" />
-      <Map s="LITT" id="586" />
-      <Map s="..|Large intestinal transit time factor intercept" id="587" />
-      <Map s="..|Large intestinal transit time factor slope" id="588" />
-      <Map s="Neighborhoods|LargeIntestine_pls_LargeIntestine_int|Surface area (plasma/interstitial)" id="589" />
-      <Map s="..|Mucosa|Caecum|Lymph flow rate" id="590" />
-      <Map s="Q_lymph_cae" id="591" />
-      <Map s="..|Mucosa|ColonAscendens|Lymph flow rate" id="592" />
-      <Map s="Q_lymph_colasc" id="593" />
-      <Map s="..|Mucosa|ColonDescendens|Lymph flow rate" id="594" />
-      <Map s="Q_lymph_coldesc" id="595" />
-      <Map s="..|Mucosa|ColonSigmoid|Lymph flow rate" id="596" />
-      <Map s="Q_lymph_colsigm" id="597" />
-      <Map s="..|Mucosa|ColonTransversum|Lymph flow rate" id="598" />
-      <Map s="Q_lymph_coltrans" id="599" />
-      <Map s="..|Mucosa|Rectum|Lymph flow rate" id="600" />
-      <Map s="Q_lymph_rect" id="601" />
-      <Map s="..|Mucosa|Caecum|Fluid recirculation flow rate" id="602" />
-      <Map s="J_iso_cae" id="603" />
-      <Map s="..|Mucosa|ColonAscendens|Fluid recirculation flow rate" id="604" />
-      <Map s="J_iso_colasc" id="605" />
-      <Map s="..|Mucosa|ColonDescendens|Fluid recirculation flow rate" id="606" />
-      <Map s="J_iso_coldesc" id="607" />
-      <Map s="..|Mucosa|ColonSigmoid|Fluid recirculation flow rate" id="608" />
-      <Map s="J_iso_colsigm" id="609" />
-      <Map s="..|Mucosa|ColonTransversum|Fluid recirculation flow rate" id="610" />
-      <Map s="J_iso_coltrans" id="611" />
-      <Map s="..|Mucosa|Rectum|Fluid recirculation flow rate" id="612" />
-      <Map s="J_iso_rect" id="613" />
-      <Map s="Neighborhoods|LargeIntestine_int_LargeIntestine_cell|MOLECULE|Partition coefficient (interstitial/water)" id="614" />
-      <Map s="Neighborhoods|LargeIntestine_int_LargeIntestine_cell|MOLECULE|Partition coefficient (intracellular/water)" id="615" />
-      <Map s="..|..|..|..|Lumen|Caecum|Volume (gut wall)" id="616" />
-      <Map s="Neighborhoods|Caecum_pls_Caecum_int|Surface area (plasma/interstitial)" id="617" />
-      <Map s="Neighborhoods|Caecum_int_Caecum_cell|MOLECULE|Partition coefficient (interstitial/water)" id="618" />
-      <Map s="Neighborhoods|Caecum_int_Caecum_cell|MOLECULE|Partition coefficient (intracellular/water)" id="619" />
-      <Map s="..|..|..|..|Lumen|ColonAscendens|Volume (gut wall)" id="620" />
-      <Map s="Neighborhoods|ColonAscendens_pls_ColonAscendens_int|Surface area (plasma/interstitial)" id="621" />
-      <Map s="Neighborhoods|ColonAscendens_int_ColonAscendens_cell|MOLECULE|Partition coefficient (interstitial/water)" id="622" />
-      <Map s="Neighborhoods|ColonAscendens_int_ColonAscendens_cell|MOLECULE|Partition coefficient (intracellular/water)" id="623" />
-      <Map s="..|..|..|..|Lumen|ColonTransversum|Volume (gut wall)" id="624" />
-      <Map s="Neighborhoods|ColonTransversum_pls_ColonTransversum_int|Surface area (plasma/interstitial)" id="625" />
-      <Map s="Neighborhoods|ColonTransversum_int_ColonTransversum_cell|MOLECULE|Partition coefficient (interstitial/water)" id="626" />
-      <Map s="Neighborhoods|ColonTransversum_int_ColonTransversum_cell|MOLECULE|Partition coefficient (intracellular/water)" id="627" />
-      <Map s="..|..|..|..|Lumen|ColonDescendens|Volume (gut wall)" id="628" />
-      <Map s="Neighborhoods|ColonDescendens_pls_ColonDescendens_int|Surface area (plasma/interstitial)" id="629" />
-      <Map s="Neighborhoods|ColonDescendens_int_ColonDescendens_cell|MOLECULE|Partition coefficient (interstitial/water)" id="630" />
-      <Map s="Neighborhoods|ColonDescendens_int_ColonDescendens_cell|MOLECULE|Partition coefficient (intracellular/water)" id="631" />
-      <Map s="..|..|..|..|Lumen|ColonSigmoid|Volume (gut wall)" id="632" />
-      <Map s="Neighborhoods|ColonSigmoid_pls_ColonSigmoid_int|Surface area (plasma/interstitial)" id="633" />
-      <Map s="Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|MOLECULE|Partition coefficient (interstitial/water)" id="634" />
-      <Map s="Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|MOLECULE|Partition coefficient (intracellular/water)" id="635" />
-      <Map s="..|..|..|..|Lumen|Rectum|Volume (gut wall)" id="636" />
-      <Map s="Neighborhoods|Rectum_pls_Rectum_int|Surface area (plasma/interstitial)" id="637" />
-      <Map s="Neighborhoods|Rectum_int_Rectum_cell|MOLECULE|Partition coefficient (interstitial/water)" id="638" />
-      <Map s="Neighborhoods|Rectum_int_Rectum_cell|MOLECULE|Partition coefficient (intracellular/water)" id="639" />
-      <Map s="Neighborhoods|Liver_pls_Liver_int|Surface area (plasma/interstitial)" id="640" />
-      <Map s="..|..|Fraction of endosomal uptake from plasma" id="641" />
-      <Map s="Liver_Parameter" id="642" />
-      <Map s="..|..|Rate constant for recycling from endosomal space" id="643" />
-      <Map s="..|..|Rate constant for endosomal uptake" id="644" />
-      <Map s="..|..|Fraction recycled to plasma" id="645" />
-      <Map s="..|..|Fraction of blood for sampling" id="646" />
-      <Map s="..|..|Density (tissue)" id="647" />
-      <Map s="..|..|Allometric scale factor" id="648" />
-      <Map s="Organism|Liver|Fraction of periportal zone" id="649" />
-      <Map s="f_periportal" id="650" />
-      <Map s="Organism|Liver|Is liver zonated" id="651" />
-      <Map s="IsLiverZonated" id="652" />
-      <Map s="Organism|Liver|Volume" id="653" />
-      <Map s="V_liv" id="654" />
-      <Map s="..|..|Radius (small pores)" id="655" />
-      <Map s="..|..|Radius (large pores)" id="656" />
-      <Map s="Neighborhoods|Periportal_pls_Periportal_int|Surface area (plasma/interstitial)" id="657" />
-      <Map s="..|..|Lymph flow rate" id="658" />
-      <Map s="..|..|Hydraulic conductivity" id="659" />
-      <Map s="Hydraulic conductivity" id="660" />
-      <Map s="..|..|Fluid recirculation flow rate" id="661" />
-      <Map s="J_iso" id="662" />
-      <Map s="..|..|Flow fraction via large pores" id="663" />
-      <Map s="..|..|Vf (neutral lipid)-PT" id="664" />
-      <Map s="..|..|Vf (lipid)" id="665" />
-      <Map s="..|..|Vf (phospholipid)-PT" id="666" />
-      <Map s="..|..|Vf (protein)" id="667" />
-      <Map s="..|..|Albumin ratio (tissue/plasma)" id="668" />
-      <Map s="..|..|Lipoprotein ratio (tissue/plasma)" id="669" />
-      <Map s="..|..|Vf (water)-PT" id="670" />
-      <Map s="..|..|Number of cells/g tissue" id="671" />
-      <Map s="Count per mass" id="672" />
-      <Map s="..|..|Microsomal protein mass/g tissue" id="673" />
-      <Map s="Mass per tissue" id="674" />
-      <Map s="..|..|Albumin ratio (tissue/plasma)-PT" id="675" />
-      <Map s="..|..|Vf (water)" id="676" />
-      <Map s="..|..|Vf (neutral lipid)-RR" id="677" />
-      <Map s="..|..|Vf (neutral lipid)-WS" id="678" />
-      <Map s="..|..|Vf (neutral phospholipid)-RR" id="679" />
-      <Map s="..|..|Vf (neutral phospholipid, plasma)-WS" id="680" />
-      <Map s="..|..|Vf (protein)-WS" id="681" />
-      <Map s="..|..|Vf (extracellular water)-RR" id="682" />
-      <Map s="..|..|Vf (water)-WS" id="683" />
-      <Map s="..|..|Vf (intracellular water)-RR" id="684" />
-      <Map s="..|..|Acidic phospholipids [mg/g] - RR" id="685" />
-      <Map s="..|..|Vf (acidic phospholipids)-WS" id="686" />
-      <Map s="..|..|Specific blood flow rate" id="687" />
-      <Map s="..|..|Blood flow rate" id="688" />
-      <Map s="Neighborhoods|Periportal_int_Periportal_cell|MOLECULE|Partition coefficient (interstitial/water)" id="689" />
-      <Map s="Organism|Liver|Intracellular|pH" id="690" />
-      <Map s="pH_cell_Liver" id="691" />
-      <Map s="Neighborhoods|Periportal_int_Periportal_cell|MOLECULE|Partition coefficient (intracellular/water)" id="692" />
-      <Map s="Neighborhoods|Pericentral_pls_Pericentral_int|Surface area (plasma/interstitial)" id="693" />
-      <Map s="Neighborhoods|Lung_pls_Lung_int|Surface area (plasma/interstitial)" id="694" />
-      <Map s="Organism|Bone|Blood flow rate" id="695" />
-      <Map s="Q_bon" id="696" />
-      <Map s="Organism|Brain|Blood flow rate" id="697" />
-      <Map s="Q_brn" id="698" />
-      <Map s="Organism|Fat|Blood flow rate" id="699" />
-      <Map s="Q_fat" id="700" />
-      <Map s="Organism|Gonads|Blood flow rate" id="701" />
-      <Map s="Q_tes" id="702" />
-      <Map s="Organism|Heart|Blood flow rate" id="703" />
-      <Map s="Q_hrt" id="704" />
-      <Map s="Organism|Kidney|Blood flow rate" id="705" />
-      <Map s="Q_kid" id="706" />
-      <Map s="Organism|LargeIntestine|Blood flow rate" id="707" />
-      <Map s="Q_lin" id="708" />
-      <Map s="Organism|Liver|Blood flow rate" id="709" />
-      <Map s="Q_liv" id="710" />
-      <Map s="Organism|Muscle|Blood flow rate" id="711" />
-      <Map s="Q_mus" id="712" />
-      <Map s="Organism|Pancreas|Blood flow rate" id="713" />
-      <Map s="Q_pan" id="714" />
-      <Map s="Organism|Skin|Blood flow rate" id="715" />
-      <Map s="Q_skn" id="716" />
-      <Map s="Organism|SmallIntestine|Blood flow rate" id="717" />
-      <Map s="Q_sin" id="718" />
-      <Map s="Organism|Spleen|Blood flow rate" id="719" />
-      <Map s="Q_spl" id="720" />
-      <Map s="Organism|Stomach|Blood flow rate" id="721" />
-      <Map s="Q_sto" id="722" />
-      <Map s="Neighborhoods|Lung_int_Lung_cell|MOLECULE|Partition coefficient (interstitial/water)" id="723" />
-      <Map s="Neighborhoods|Lung_int_Lung_cell|MOLECULE|Partition coefficient (intracellular/water)" id="724" />
-      <Map s="Neighborhoods|Muscle_pls_Muscle_int|Surface area (plasma/interstitial)" id="725" />
-      <Map s="Neighborhoods|Muscle_int_Muscle_cell|MOLECULE|Partition coefficient (interstitial/water)" id="726" />
-      <Map s="Neighborhoods|Muscle_int_Muscle_cell|MOLECULE|Partition coefficient (intracellular/water)" id="727" />
-      <Map s="Neighborhoods|Pancreas_pls_Pancreas_int|Surface area (plasma/interstitial)" id="728" />
-      <Map s="Neighborhoods|Pancreas_int_Pancreas_cell|MOLECULE|Partition coefficient (interstitial/water)" id="729" />
-      <Map s="Neighborhoods|Pancreas_int_Pancreas_cell|MOLECULE|Partition coefficient (intracellular/water)" id="730" />
-      <Map s="Organism|LargeIntestine|Lymph flow rate (incl. mucosa)" id="731" />
-      <Map s="Q_Lymph_lin_incl_Mucosa" id="732" />
-      <Map s="Organism|Pancreas|Lymph flow rate" id="733" />
-      <Map s="Q_Lymph_pan" id="734" />
-      <Map s="Organism|SmallIntestine|Lymph flow rate (incl. mucosa)" id="735" />
-      <Map s="Q_Lymph_sin_incl_Mucosa" id="736" />
-      <Map s="Organism|Spleen|Lymph flow rate" id="737" />
-      <Map s="Q_Lymph_spl" id="738" />
-      <Map s="Organism|Stomach|Lymph flow rate" id="739" />
-      <Map s="Q_Lymph_sto" id="740" />
-      <Map s="Neighborhoods|Skin_pls_Skin_int|Surface area (plasma/interstitial)" id="741" />
-      <Map s="Neighborhoods|Skin_int_Skin_cell|MOLECULE|Partition coefficient (interstitial/water)" id="742" />
-      <Map s="Neighborhoods|Skin_int_Skin_cell|MOLECULE|Partition coefficient (intracellular/water)" id="743" />
-      <Map s="Neighborhoods|Spleen_pls_Spleen_int|Surface area (plasma/interstitial)" id="744" />
-      <Map s="Neighborhoods|Spleen_int_Spleen_cell|MOLECULE|Partition coefficient (interstitial/water)" id="745" />
-      <Map s="Neighborhoods|Spleen_int_Spleen_cell|MOLECULE|Partition coefficient (intracellular/water)" id="746" />
-      <Map s="Organism|EndogenousIgG|f_membrane_pls" id="747" />
-      <Map s="f_mem_pls" id="748" />
-      <Map s="Organism|EndogenousIgG|Fraction of endosomal uptake from plasma" id="749" />
-      <Map s="f_uptake_vas" id="750" />
-      <Map s="Organism|EndogenousIgG|Rate constant for endosomal uptake" id="751" />
-      <Map s="Organism|EndogenousIgG|Endosome|Volume" id="752" />
-      <Map s="V_end" id="753" />
-      <Map s="Organism|EndogenousIgG|f_membrane_int" id="754" />
-      <Map s="f_mem_int" id="755" />
-      <Map s="Volume_EndogenIgG_endosom" id="756" />
-      <Map s="Organism|EndogenousIgG|Plasma|Volume" id="757" />
-      <Map s="Volume_EndogenIgG_pls" id="758" />
-      <Map s="Organism|EndogenousIgG|Interstitial|Volume" id="759" />
-      <Map s="Volume_EndogenIgG_int" id="760" />
-      <Map s="..|Radius ratio (solute/small pores)" id="761" />
-      <Map s="gamma" id="762" />
-      <Map s="..|Radius ratio (solute/large pores)" id="763" />
-      <Map s="..|Radius (small pores)" id="764" />
-      <Map s="r_s" id="765" />
-      <Map s="Organism|EndogenousIgG|Radius (endogeneous IgG)" id="766" />
-      <Map s="a_e_endog" id="767" />
-      <Map s="..|Hydraulic conductivity" id="768" />
-      <Map s="Lp" id="769" />
-      <Map s="..|Radius (large pores)" id="770" />
-      <Map s="r" id="771" />
-      <Map s="Organism|Na" id="772" />
-      <Map s="Na" id="773" />
-      <Map s="Inversed mol" id="774" />
-      <Map s="Organism|R*T" id="775" />
-      <Map s="RT" id="776" />
-      <Map s="..|igg_k_diff_pls" id="777" />
-      <Map s="k_diff_pls" id="778" />
-      <Map s="Organism|EndogenousIgG|Fraction recycled to plasma" id="779" />
-      <Map s="f_rec_vas" id="780" />
-      <Map s="Organism|EndogenousIgG|Rate constant for recycling from endosomal space" id="781" />
-      <Map s="Organism|EndogenousIgG|Endosome|Specific endosomal clearance" id="782" />
-      <Map s="CLspec" id="783" />
-      <Map s="..|igg_k_conv" id="784" />
-      <Map s="k_conv" id="785" />
-      <Map s="..|igg_k_diff_int" id="786" />
-      <Map s="k_diff_int" id="787" />
-      <Map s="..|IgG_kdeg" id="788" />
-      <Map s="kdeg" id="789" />
-      <Map s="..|IgG_kei" id="790" />
-      <Map s="kei" id="791" />
-      <Map s="..|IgG_kep" id="792" />
-      <Map s="kep" id="793" />
-      <Map s="..|IgG_kie" id="794" />
-      <Map s="kie" id="795" />
-      <Map s="..|IgG_kpe" id="796" />
-      <Map s="kpe" id="797" />
-      <Map s="..|kass (FcRn, endogenous IgG)" id="798" />
-      <Map s="ka" id="799" />
-      <Map s="Second order rate constant" id="800" />
-      <Map s="..|Kd (FcRn, endogenous IgG) in endosomal space" id="801" />
-      <Map s="Kd" id="802" />
-      <Map s="Ql" id="803" />
-      <Map s="..|Endosome|Volume" id="804" />
-      <Map s="Ve" id="805" />
-      <Map s="Organism|EndogenousIgG|Endosome|Start concentration of free FcRn (endosome)" id="806" />
-      <Map s="FcRnEnd" id="807" />
-      <Map s="Organism|EndogenousIgG|Plasma|Start concentration of free endogenous IgG (plasma)" id="808" />
-      <Map s="Cpl" id="809" />
-      <Map s="..|Fluid recirculation flow rate" id="810" />
-      <Map s="..|P (small endothelial pores)" id="811" />
-      <Map s="P_endothelial_s" id="812" />
-      <Map s="..|Reflection coefficient (small pores)" id="813" />
-      <Map s="sigma_s" id="814" />
-      <Map s="Neighborhoods|EndogenousIgG_int_EndogenousIgG_pls|Surface area (plasma/interstitial)" id="815" />
-      <Map s="r_l" id="816" />
-      <Map s="..|P (large endothelial pores)" id="817" />
-      <Map s="P_endothelial_l" id="818" />
-      <Map s="..|Reflection coefficient (large pores)" id="819" />
-      <Map s="sigma_l" id="820" />
-      <Map s="..|Peclet number (large pores)" id="821" />
-      <Map s="Pe_l" id="822" />
-      <Map s="..|Peclet number (small pores)" id="823" />
-      <Map s="Pe_s" id="824" />
-      <Map s="Organism|Bone|Fluid recirculation flow rate" id="825" />
-      <Map s="J_iso_bon" id="826" />
-      <Map s="Organism|Brain|Fluid recirculation flow rate" id="827" />
-      <Map s="J_iso_brn" id="828" />
-      <Map s="Organism|Fat|Fluid recirculation flow rate" id="829" />
-      <Map s="J_iso_fat" id="830" />
-      <Map s="Organism|Gonads|Fluid recirculation flow rate" id="831" />
-      <Map s="J_iso_tes" id="832" />
-      <Map s="Organism|Heart|Fluid recirculation flow rate" id="833" />
-      <Map s="J_iso_hrt" id="834" />
-      <Map s="Organism|Kidney|Fluid recirculation flow rate" id="835" />
-      <Map s="J_iso_kid" id="836" />
-      <Map s="Organism|LargeIntestine|Fluid recirculation flow rate (incl. mucosa)" id="837" />
-      <Map s="J_iso_lin" id="838" />
-      <Map s="Organism|Liver|Fluid recirculation flow rate" id="839" />
-      <Map s="J_iso_liv" id="840" />
-      <Map s="Organism|Lung|Fluid recirculation flow rate" id="841" />
-      <Map s="J_iso_lng" id="842" />
-      <Map s="Organism|Muscle|Fluid recirculation flow rate" id="843" />
-      <Map s="J_iso_mus" id="844" />
-      <Map s="Organism|Pancreas|Fluid recirculation flow rate" id="845" />
-      <Map s="J_iso_pan" id="846" />
-      <Map s="Organism|Skin|Fluid recirculation flow rate" id="847" />
-      <Map s="J_iso_skn" id="848" />
-      <Map s="Organism|SmallIntestine|Fluid recirculation flow rate (incl. mucosa)" id="849" />
-      <Map s="J_iso_sin" id="850" />
-      <Map s="Organism|Spleen|Fluid recirculation flow rate" id="851" />
-      <Map s="J_iso_spl" id="852" />
-      <Map s="Organism|Stomach|Fluid recirculation flow rate" id="853" />
-      <Map s="J_iso_sto" id="854" />
-      <Map s="Organism|Bone|Lymph flow rate" id="855" />
-      <Map s="Q_lymph_bon" id="856" />
-      <Map s="Organism|Brain|Lymph flow rate" id="857" />
-      <Map s="Q_lymph_brn" id="858" />
-      <Map s="Organism|Fat|Lymph flow rate" id="859" />
-      <Map s="Q_lymph_fat" id="860" />
-      <Map s="Organism|Gonads|Lymph flow rate" id="861" />
-      <Map s="Q_lymph_tes" id="862" />
-      <Map s="Organism|Heart|Lymph flow rate" id="863" />
-      <Map s="Q_lymph_hrt" id="864" />
-      <Map s="Organism|Kidney|Lymph flow rate" id="865" />
-      <Map s="Q_lymph_kid" id="866" />
-      <Map s="Q_lymph_lin" id="867" />
-      <Map s="Organism|Liver|Lymph flow rate" id="868" />
-      <Map s="Q_lymph_liv" id="869" />
-      <Map s="Organism|Lung|Lymph flow rate" id="870" />
-      <Map s="Q_lymph_lng" id="871" />
-      <Map s="Organism|Muscle|Lymph flow rate" id="872" />
-      <Map s="Q_lymph_mus" id="873" />
-      <Map s="Q_lymph_pan" id="874" />
-      <Map s="Organism|Skin|Lymph flow rate" id="875" />
-      <Map s="Q_lymph_skn" id="876" />
-      <Map s="Q_lymph_sin" id="877" />
-      <Map s="Q_lymph_spl" id="878" />
-      <Map s="Q_lymph_sto" id="879" />
-      <Map s="Organism|EndogenousIgG|Kd (FcRn, endogenous IgG) in plasma/interstitial" id="880" />
-      <Map s="Kd_FcRn_LigandEndo" id="881" />
-      <Map s="V_colasc" id="882" />
-      <Map s="V_coldesc" id="883" />
-      <Map s="V_colsigm" id="884" />
-      <Map s="V_coltrans" id="885" />
-      <Map s="V_rect" id="886" />
-      <Map s="V_bon" id="887" />
-      <Map s="V_brn" id="888" />
-      <Map s="V_fat" id="889" />
-      <Map s="V_tes" id="890" />
-      <Map s="V_hrt" id="891" />
-      <Map s="V_kid" id="892" />
-      <Map s="V_lin" id="893" />
-      <Map s="Organism|Liver|Plasma|Volume" id="894" />
-      <Map s="V_lng" id="895" />
-      <Map s="V_mus" id="896" />
-      <Map s="V_pan" id="897" />
-      <Map s="V_skn" id="898" />
-      <Map s="V_sin" id="899" />
-      <Map s="V_spl" id="900" />
-      <Map s="V_sto" id="901" />
-      <Map s="Organism|LargeIntestine|Mucosa|Caecum|Interstitial|Volume" id="902" />
-      <Map s="Organism|LargeIntestine|Mucosa|ColonAscendens|Interstitial|Volume" id="903" />
-      <Map s="Organism|LargeIntestine|Mucosa|ColonDescendens|Interstitial|Volume" id="904" />
-      <Map s="Organism|LargeIntestine|Mucosa|ColonSigmoid|Interstitial|Volume" id="905" />
-      <Map s="Organism|LargeIntestine|Mucosa|ColonTransversum|Interstitial|Volume" id="906" />
-      <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Interstitial|Volume" id="907" />
-      <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Interstitial|Volume" id="908" />
-      <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Interstitial|Volume" id="909" />
-      <Map s="Organism|LargeIntestine|Mucosa|Rectum|Interstitial|Volume" id="910" />
-      <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Interstitial|Volume" id="911" />
-      <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Interstitial|Volume" id="912" />
-      <Map s="Organism|Bone|Interstitial|Volume" id="913" />
-      <Map s="Organism|Brain|Interstitial|Volume" id="914" />
-      <Map s="Organism|Fat|Interstitial|Volume" id="915" />
-      <Map s="Organism|Gonads|Interstitial|Volume" id="916" />
-      <Map s="Organism|Heart|Interstitial|Volume" id="917" />
-      <Map s="Organism|Kidney|Interstitial|Volume" id="918" />
-      <Map s="Organism|LargeIntestine|Interstitial|Volume" id="919" />
-      <Map s="Organism|Liver|Interstitial|Volume" id="920" />
-      <Map s="Organism|Lung|Interstitial|Volume" id="921" />
-      <Map s="Organism|Muscle|Interstitial|Volume" id="922" />
-      <Map s="Organism|Pancreas|Interstitial|Volume" id="923" />
-      <Map s="Organism|Skin|Interstitial|Volume" id="924" />
-      <Map s="Organism|SmallIntestine|Interstitial|Volume" id="925" />
-      <Map s="Organism|Spleen|Interstitial|Volume" id="926" />
-      <Map s="Organism|Stomach|Interstitial|Volume" id="927" />
-      <Map s="Organism|EndogenousIgG|Kd (FcRn, endogenous IgG) in endosomal space" id="928" />
-      <Map s="Organism|Specific clearance (endosome)" id="929" />
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-      <Map s="Organism|LargeIntestine|Mucosa|Caecum|Endosome|Volume" id="931" />
-      <Map s="Organism|LargeIntestine|Mucosa|ColonAscendens|Endosome|Volume" id="932" />
-      <Map s="Organism|LargeIntestine|Mucosa|ColonDescendens|Endosome|Volume" id="933" />
-      <Map s="Organism|LargeIntestine|Mucosa|ColonSigmoid|Endosome|Volume" id="934" />
-      <Map s="Organism|LargeIntestine|Mucosa|ColonTransversum|Endosome|Volume" id="935" />
-      <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Endosome|Volume" id="936" />
-      <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Endosome|Volume" id="937" />
-      <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Endosome|Volume" id="938" />
-      <Map s="Organism|LargeIntestine|Mucosa|Rectum|Endosome|Volume" id="939" />
-      <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Endosome|Volume" id="940" />
-      <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Endosome|Volume" id="941" />
-      <Map s="Organism|Bone|Endosome|Volume" id="942" />
-      <Map s="Organism|Brain|Endosome|Volume" id="943" />
-      <Map s="Organism|Fat|Endosome|Volume" id="944" />
-      <Map s="Organism|Gonads|Endosome|Volume" id="945" />
-      <Map s="Organism|Heart|Endosome|Volume" id="946" />
-      <Map s="Organism|Kidney|Endosome|Volume" id="947" />
-      <Map s="Organism|LargeIntestine|Endosome|Volume" id="948" />
-      <Map s="Organism|Liver|Endosome|Volume" id="949" />
-      <Map s="Organism|Lung|Endosome|Volume" id="950" />
-      <Map s="Organism|Muscle|Endosome|Volume" id="951" />
-      <Map s="Organism|Pancreas|Endosome|Volume" id="952" />
-      <Map s="Organism|Skin|Endosome|Volume" id="953" />
-      <Map s="Organism|SmallIntestine|Endosome|Volume" id="954" />
-      <Map s="Organism|Spleen|Endosome|Volume" id="955" />
-      <Map s="Organism|Stomach|Endosome|Volume" id="956" />
-      <Map s="Organism|Saliva|Volume" id="957" />
-      <Map s="V_slv" id="958" />
-      <Map s="FIRST_NEIGHBOR|..|Volume" id="959" />
-      <Map s="Organism|Surface/Volume ratio (blood cells)" id="960" />
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-      <Map s="FIRST_NEIGHBOR|..|Fraction vascular" id="962" />
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-      <Map s="FIRST_NEIGHBOR|..|Flow fraction via large pores" id="967" />
-      <Map s="FIRST_NEIGHBOR|..|Hydraulic conductivity" id="968" />
-      <Map s="FIRST_NEIGHBOR|..|Radius (small pores)" id="969" />
-      <Map s="FIRST_NEIGHBOR|..|Radius (large pores)" id="970" />
-      <Map s="FIRST_NEIGHBOR|..|Fluid recirculation flow rate" id="971" />
-      <Map s="FIRST_NEIGHBOR|..|Lymph flow rate" id="972" />
-      <Map s="..|..|Surface area (plasma/interstitial)" id="973" />
-      <Map s="..|P (intracellular-&gt;interstitial)" id="974" />
-      <Map s="P_cell_int" id="975" />
-      <Map s="..|..|Surface area (interstitial/intracellular)" id="976" />
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-      <Map s="..|Partition coefficient (intracellular/plasma)" id="978" />
-      <Map s="K_cell_pls" id="979" />
-      <Map s="..|P (interstitial-&gt;intracellular)" id="980" />
-      <Map s="P_int_cell" id="981" />
-      <Map s="..|P_cell_int_factor" id="982" />
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-      <Map s="..|P_int_cell_factor" id="984" />
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-      <Map s="FIRST_NEIGHBOR|MOLECULE|Concentration" id="986" />
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-      <Map s="FIRST_NEIGHBOR|..|Blood flow rate" id="988" />
-      <Map s="FIRST_NEIGHBOR|pH" id="989" />
-      <Map s="SECOND_NEIGHBOR|pH" id="990" />
-      <Map s="..|pKa_pH_WS_cell_F1" id="991" />
-      <Map s="..|pKa_pH_WS_cell_F2" id="992" />
-      <Map s="..|pKa_pH_WS_cell_F3" id="993" />
-      <Map s="FIRST_NEIGHBOR|Effective surface area" id="994" />
-      <Map s="Aeff" id="995" />
-      <Map s="FIRST_NEIGHBOR|Liquid" id="996" />
-      <Map s="FIRST_NEIGHBOR|MOLECULE" id="997" />
-      <Map s="DrugLiquid" id="998" />
-      <Map s="Amount" id="999" />
-      <Map s="SECOND_NEIGHBOR|MOLECULE|Concentration" id="1000" />
-      <Map s="DrugMucosa" id="1001" />
-      <Map s="MOLECULE|Intestinal permeability (transcellular)" id="1002" />
-      <Map s="MOLECULE|Molecular weight" id="1003" />
-      <Map s="MW" id="1004" />
-      <Map s="Molecular weight" id="1005" />
-      <Map s="NEIGHBORHOOD|MOLECULE|P_int_trans_cell_lum_factor" id="1006" />
-      <Map s="P_int_trans_cell_lum_factor" id="1007" />
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-      <Map s="FIRST_NEIGHBOR|..|OralApplicationsEnabled" id="1011" />
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-      <Map s="..|pKa_pH_WS_cell_K2" id="1015" />
-      <Map s="..|pKa_pH_WS_cell_K3" id="1016" />
-      <Map s="..|pKa_pH_WS_cell_K4" id="1017" />
-      <Map s="..|pKa_pH_WS_cell_K5" id="1018" />
-      <Map s="..|pKa_pH_WS_cell_K6" id="1019" />
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-      <Map s="..|pKa_pH_WS_cell_K8" id="1021" />
-      <Map s="MOLECULE|base_For_Pint_Factor" id="1022" />
-      <Map s="MOLECULE|Use pH- and pKa-dependent penalty factor for charged molecule fraction" id="1023" />
-      <Map s="UsePenaltyFactor" id="1024" />
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-      <Map s="MOLECULE|Intestinal permeability (paracellular)" id="1026" />
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-      <Map s="Organism|Lumen|Caecum|MOLECULE|Oral mass absorbed segment" id="1032" />
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-      <Map s="Organism|Lumen|Duodenum|MOLECULE|Oral mass absorbed segment" id="1042" />
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-      <Map s="MAbs_rect" id="1049" />
-      <Map s="Organism|Lumen|UpperIleum|MOLECULE|Oral mass absorbed segment" id="1050" />
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-      <Map s="Organism|Lumen|UpperJejunum|MOLECULE|Oral mass absorbed segment" id="1052" />
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-      <Map s="SECOND_NEIGHBOR|..|Blood flow rate" id="1055" />
-      <Map s="SECOND_NEIGHBOR|..|Lymph flow rate" id="1056" />
-      <Map s="Neighborhoods|LowerIleum_int_LowerIleum_cell|MOLECULE|Partition coefficient (intracellular/plasma)" id="1057" />
-      <Map s="Organism|SmallIntestine|Volume (mucosa)" id="1058" />
-      <Map s="FIRST_NEIGHBOR|..|Volume (mucosa)" id="1059" />
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-      <Map s="Neighborhoods|Liver_int_Liver_cell|Surface area (interstitial/intracellular)" id="1061" />
-      <Map s="SA_int_cell" id="1062" />
-      <Map s="Neighborhoods|Liver_pls_Liver_bc|Surface area (blood cells/plasma)" id="1063" />
-      <Map s="SA_pls_bc" id="1064" />
-      <Map s="Neighborhoods|Rectum_int_Rectum_cell|MOLECULE|Partition coefficient (intracellular/plasma)" id="1065" />
-      <Map s="SA_pls_int_bon" id="1066" />
-      <Map s="SA_pls_int_brn" id="1067" />
-      <Map s="SA_pls_int_fat" id="1068" />
-      <Map s="SA_pls_int_tes" id="1069" />
-      <Map s="SA_pls_int_hrt" id="1070" />
-      <Map s="SA_pls_int_kid" id="1071" />
-      <Map s="SA_pls_int_lin" id="1072" />
-      <Map s="SA_pls_int_liv" id="1073" />
-      <Map s="SA_pls_int_lng" id="1074" />
-      <Map s="SA_pls_int_mus" id="1075" />
-      <Map s="SA_pls_int_pan" id="1076" />
-      <Map s="SA_pls_int_skn" id="1077" />
-      <Map s="SA_pls_int_sin" id="1078" />
-      <Map s="SA_pls_int_spl" id="1079" />
-      <Map s="SA_pls_int_sto" id="1080" />
-      <Map s="..|SalivaPlasmaRatio" id="1081" />
-      <Map s="R" id="1082" />
-      <Map s="SECOND_NEIGHBOR|pH (saliva)" id="1083" />
-      <Map s="pH_slv" id="1084" />
-      <Map s="Organism|pH (plasma)" id="1085" />
-      <Map s="pH_PLS" id="1086" />
-      <Map s="Organism|Lumen|Duodenum|Effective surface area" id="1087" />
-      <Map s="Organism|Lumen|Duodenum|Microvilli factor" id="1088" />
-      <Map s="MicrovilliFactor" id="1089" />
-      <Map s="MOLECULE|Mucosa permeability scale factor (transcellular)" id="1090" />
-      <Map s="P_int_scalefactor" id="1091" />
-      <Map s="Organism|Lumen|UpperJejunum|Effective surface area" id="1092" />
-      <Map s="Organism|Lumen|UpperJejunum|Microvilli factor" id="1093" />
-      <Map s="Organism|Lumen|LowerJejunum|Effective surface area" id="1094" />
-      <Map s="Organism|Lumen|LowerJejunum|Microvilli factor" id="1095" />
-      <Map s="Organism|Lumen|UpperIleum|Effective surface area" id="1096" />
-      <Map s="Organism|Lumen|UpperIleum|Microvilli factor" id="1097" />
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-      <Map s="Organism|Lumen|LowerIleum|Microvilli factor" id="1099" />
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-      <Map s="Organism|Lumen|Caecum|Microvilli factor" id="1101" />
-      <Map s="Organism|Lumen|ColonAscendens|Effective surface area" id="1102" />
-      <Map s="Organism|Lumen|ColonAscendens|Microvilli factor" id="1103" />
-      <Map s="Organism|Lumen|ColonTransversum|Effective surface area" id="1104" />
-      <Map s="Organism|Lumen|ColonTransversum|Microvilli factor" id="1105" />
-      <Map s="Organism|Lumen|ColonDescendens|Effective surface area" id="1106" />
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-      <Map s="Organism|Lumen|ColonSigmoid|Effective surface area" id="1108" />
-      <Map s="Organism|Lumen|ColonSigmoid|Microvilli factor" id="1109" />
-      <Map s="Organism|Lumen|Rectum|Effective surface area" id="1110" />
-      <Map s="Organism|Lumen|Rectum|Microvilli factor" id="1111" />
-      <Map s="Neighborhoods|Duodenum_int_Duodenum_cell|MOLECULE|Partition coefficient (intracellular/plasma)" id="1112" />
-      <Map s="Neighborhoods|Caecum_int_Caecum_cell|MOLECULE|Partition coefficient (intracellular/plasma)" id="1113" />
-      <Map s="Neighborhoods|ColonDescendens_int_ColonDescendens_cell|MOLECULE|Partition coefficient (intracellular/plasma)" id="1114" />
-      <Map s="Neighborhoods|ColonTransversum_int_ColonTransversum_cell|MOLECULE|Partition coefficient (intracellular/plasma)" id="1115" />
-      <Map s="Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|MOLECULE|Partition coefficient (intracellular/plasma)" id="1116" />
-      <Map s="Neighborhoods|ColonAscendens_int_ColonAscendens_cell|MOLECULE|Partition coefficient (intracellular/plasma)" id="1117" />
-      <Map s="Mean" id="1118" />
-      <Map s="Deviation" id="1119" />
-      <Map s="GeometricDeviation" id="1120" />
+      <Map s=".." id="332" />
+      <Map s="M" id="333" />
+      <Map s="Amount" id="334" />
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+      <Map s="MOLECULE|Enable supersaturation" id="336" />
+      <Map s="EnableSupersaturarion" id="337" />
+      <Map s="MOLECULE|Molecular weight" id="338" />
+      <Map s="MW" id="339" />
+      <Map s="Molecular weight" id="340" />
+      <Map s="..|..|Liquid" id="341" />
+      <Map s="alpha" id="342" />
+      <Map s="k" id="343" />
+      <Map s="inflow" id="344" />
+      <Map s="..|..|Stomach|Fractional steady state fill level" id="345" />
+      <Map s="alpha_p" id="346" />
+      <Map s="..|..|Stomach|Intestinal transit rate (absolute)" id="347" />
+      <Map s="k_p" id="348" />
+      <Map s="..|..|Stomach|Volume" id="349" />
+      <Map s="V_p" id="350" />
+      <Map s="..|..|..|Height" id="351" />
+      <Map s="..|r2_p0" id="352" />
+      <Map s="r2_p0" id="353" />
+      <Map s="..|r2_p1" id="354" />
+      <Map s="r2_p1" id="355" />
+      <Map s="..|Effective surface area enhancement factor" id="356" />
+      <Map s="AeffFactor" id="357" />
+      <Map s="Ageom" id="358" />
+      <Map s="Organism|Lumen|Effective surface area variability factor" id="359" />
+      <Map s="AeffVariabilityFactor" id="360" />
+      <Map s="..|Intestinal transit rate" id="361" />
+      <Map s="LuminalVelocity" id="362" />
+      <Map s="Organism|SmallIntestine|Small intestinal transit time factor" id="363" />
+      <Map s="SITT_fact" id="364" />
+      <Map s="..|L_p0" id="365" />
+      <Map s="L_p0" id="366" />
+      <Map s="..|L_p1" id="367" />
+      <Map s="L_p1" id="368" />
+      <Map s="..|Absorption of liquid" id="369" />
+      <Map s="Outflow" id="370" />
+      <Map s="LT_duo" id="371" />
+      <Map s="..|..|Stomach|Liquid transfer rate" id="372" />
+      <Map s="..|..|UpperJejunum|FillLevelFlag" id="373" />
+      <Map s="..|r1_p0" id="374" />
+      <Map s="r1_p0" id="375" />
+      <Map s="..|r1_p1" id="376" />
+      <Map s="r1_p1" id="377" />
+      <Map s="..|Thickness_p1" id="378" />
+      <Map s="Thickness_p1" id="379" />
+      <Map s="..|Thickness_p2" id="380" />
+      <Map s="Thickness_p2" id="381" />
+      <Map s="..|Thickness_p3" id="382" />
+      <Map s="Thickness_p3" id="383" />
+      <Map s="Inversed length" id="384" />
+      <Map s="Organism|SmallIntestine|Volume" id="385" />
+      <Map s="V_Intestine" id="386" />
+      <Map s="Neighborhoods|Lumen_duo_Duodenum_pls|MOLECULE|Sum of active process rates" id="387" />
+      <Map s="ActiveRates_para" id="388" />
+      <Map s="Amount per time" id="389" />
+      <Map s="Neighborhoods|Lumen_duo_Duodenum_cell|MOLECULE|Sum of active process rates" id="390" />
+      <Map s="ActiveRates_trans" id="391" />
+      <Map s="Neighborhoods|Lumen_duo_Duodenum_pls|MOLECULE|Sum of passive process rates" id="392" />
+      <Map s="PassiveRates_para" id="393" />
+      <Map s="Neighborhoods|Lumen_duo_Duodenum_cell|MOLECULE|Sum of passive process rates" id="394" />
+      <Map s="PassiveRates_trans" id="395" />
+      <Map s="..|..|Duodenum|Fractional steady state fill level" id="396" />
+      <Map s="..|..|Duodenum|Intestinal transit rate (absolute)" id="397" />
+      <Map s="..|..|Duodenum|Volume" id="398" />
+      <Map s="LT_uje" id="399" />
+      <Map s="..|..|Duodenum|Liquid transfer rate" id="400" />
+      <Map s="..|..|LowerJejunum|FillLevelFlag" id="401" />
+      <Map s="Neighborhoods|Lumen_uje_UpperJejunum_pls|MOLECULE|Sum of active process rates" id="402" />
+      <Map s="Neighborhoods|Lumen_uje_UpperJejunum_cell|MOLECULE|Sum of active process rates" id="403" />
+      <Map s="Neighborhoods|Lumen_uje_UpperJejunum_pls|MOLECULE|Sum of passive process rates" id="404" />
+      <Map s="Neighborhoods|Lumen_uje_UpperJejunum_cell|MOLECULE|Sum of passive process rates" id="405" />
+      <Map s="..|..|UpperJejunum|Fractional steady state fill level" id="406" />
+      <Map s="..|..|UpperJejunum|Intestinal transit rate (absolute)" id="407" />
+      <Map s="..|..|UpperJejunum|Volume" id="408" />
+      <Map s="LT_lje" id="409" />
+      <Map s="..|..|UpperJejunum|Liquid transfer rate" id="410" />
+      <Map s="..|..|UpperIleum|FillLevelFlag" id="411" />
+      <Map s="Neighborhoods|Lumen_lje_LowerJejunum_pls|MOLECULE|Sum of active process rates" id="412" />
+      <Map s="Neighborhoods|Lumen_lje_LowerJejunum_cell|MOLECULE|Sum of active process rates" id="413" />
+      <Map s="Neighborhoods|Lumen_lje_LowerJejunum_pls|MOLECULE|Sum of passive process rates" id="414" />
+      <Map s="Neighborhoods|Lumen_lje_LowerJejunum_cell|MOLECULE|Sum of passive process rates" id="415" />
+      <Map s="..|..|LowerJejunum|Fractional steady state fill level" id="416" />
+      <Map s="..|..|LowerJejunum|Intestinal transit rate (absolute)" id="417" />
+      <Map s="..|..|LowerJejunum|Volume" id="418" />
+      <Map s="LT_uil" id="419" />
+      <Map s="..|..|LowerJejunum|Liquid transfer rate" id="420" />
+      <Map s="..|..|LowerIleum|FillLevelFlag" id="421" />
+      <Map s="Neighborhoods|Lumen_uil_UpperIleum_pls|MOLECULE|Sum of active process rates" id="422" />
+      <Map s="Neighborhoods|Lumen_uil_UpperIleum_cell|MOLECULE|Sum of active process rates" id="423" />
+      <Map s="Neighborhoods|Lumen_uil_UpperIleum_pls|MOLECULE|Sum of passive process rates" id="424" />
+      <Map s="Neighborhoods|Lumen_uil_UpperIleum_cell|MOLECULE|Sum of passive process rates" id="425" />
+      <Map s="..|..|UpperIleum|Fractional steady state fill level" id="426" />
+      <Map s="..|..|UpperIleum|Intestinal transit rate (absolute)" id="427" />
+      <Map s="..|..|UpperIleum|Volume" id="428" />
+      <Map s="LT_lil" id="429" />
+      <Map s="..|..|UpperIleum|Liquid transfer rate" id="430" />
+      <Map s="..|..|Caecum|FillLevelFlag" id="431" />
+      <Map s="Neighborhoods|Lumen_lil_LowerIleum_pls|MOLECULE|Sum of active process rates" id="432" />
+      <Map s="Neighborhoods|Lumen_lil_LowerIleum_cell|MOLECULE|Sum of active process rates" id="433" />
+      <Map s="Neighborhoods|Lumen_lil_LowerIleum_pls|MOLECULE|Sum of passive process rates" id="434" />
+      <Map s="Neighborhoods|Lumen_lil_LowerIleum_cell|MOLECULE|Sum of passive process rates" id="435" />
+      <Map s="..|..|LowerIleum|Fractional steady state fill level" id="436" />
+      <Map s="..|..|LowerIleum|Intestinal transit rate (absolute)" id="437" />
+      <Map s="..|..|LowerIleum|Volume" id="438" />
+      <Map s="Organism|LargeIntestine|Large intestinal transit time factor" id="439" />
+      <Map s="LITT_fact" id="440" />
+      <Map s="LT_cae" id="441" />
+      <Map s="..|..|LowerIleum|Liquid transfer rate" id="442" />
+      <Map s="..|..|ColonAscendens|FillLevelFlag" id="443" />
+      <Map s="Organism|LargeIntestine|Volume" id="444" />
+      <Map s="Neighborhoods|Lumen_cae_Caecum_pls|MOLECULE|Sum of active process rates" id="445" />
+      <Map s="Neighborhoods|Lumen_cae_Caecum_cell|MOLECULE|Sum of active process rates" id="446" />
+      <Map s="Neighborhoods|Lumen_cae_Caecum_pls|MOLECULE|Sum of passive process rates" id="447" />
+      <Map s="Neighborhoods|Lumen_cae_Caecum_cell|MOLECULE|Sum of passive process rates" id="448" />
+      <Map s="..|..|Caecum|Fractional steady state fill level" id="449" />
+      <Map s="..|..|Caecum|Intestinal transit rate (absolute)" id="450" />
+      <Map s="..|..|Caecum|Volume" id="451" />
+      <Map s="LT_colasc" id="452" />
+      <Map s="..|..|Caecum|Liquid transfer rate" id="453" />
+      <Map s="..|..|ColonTransversum|FillLevelFlag" id="454" />
+      <Map s="Neighborhoods|Lumen_colasc_ColonAscendens_pls|MOLECULE|Sum of active process rates" id="455" />
+      <Map s="Neighborhoods|Lumen_colasc_ColonAscendens_cell|MOLECULE|Sum of active process rates" id="456" />
+      <Map s="Neighborhoods|Lumen_colasc_ColonAscendens_pls|MOLECULE|Sum of passive process rates" id="457" />
+      <Map s="Neighborhoods|Lumen_colasc_ColonAscendens_cell|MOLECULE|Sum of passive process rates" id="458" />
+      <Map s="..|..|ColonAscendens|Fractional steady state fill level" id="459" />
+      <Map s="..|..|ColonAscendens|Intestinal transit rate (absolute)" id="460" />
+      <Map s="..|..|ColonAscendens|Volume" id="461" />
+      <Map s="LT_coltrans" id="462" />
+      <Map s="..|..|ColonAscendens|Liquid transfer rate" id="463" />
+      <Map s="..|..|ColonDescendens|FillLevelFlag" id="464" />
+      <Map s="Neighborhoods|Lumen_coltrans_ColonTransversum_pls|MOLECULE|Sum of active process rates" id="465" />
+      <Map s="Neighborhoods|Lumen_coltrans_ColonTransversum_cell|MOLECULE|Sum of active process rates" id="466" />
+      <Map s="Neighborhoods|Lumen_coltrans_ColonTransversum_pls|MOLECULE|Sum of passive process rates" id="467" />
+      <Map s="Neighborhoods|Lumen_coltrans_ColonTransversum_cell|MOLECULE|Sum of passive process rates" id="468" />
+      <Map s="..|..|ColonTransversum|Fractional steady state fill level" id="469" />
+      <Map s="..|..|ColonTransversum|Intestinal transit rate (absolute)" id="470" />
+      <Map s="..|..|ColonTransversum|Volume" id="471" />
+      <Map s="LT_coldesc" id="472" />
+      <Map s="..|..|ColonTransversum|Liquid transfer rate" id="473" />
+      <Map s="..|..|ColonSigmoid|FillLevelFlag" id="474" />
+      <Map s="Neighborhoods|Lumen_coldesc_ColonDescendens_pls|MOLECULE|Sum of active process rates" id="475" />
+      <Map s="Neighborhoods|Lumen_coldesc_ColonDescendens_cell|MOLECULE|Sum of active process rates" id="476" />
+      <Map s="Neighborhoods|Lumen_coldesc_ColonDescendens_pls|MOLECULE|Sum of passive process rates" id="477" />
+      <Map s="Neighborhoods|Lumen_coldesc_ColonDescendens_cell|MOLECULE|Sum of passive process rates" id="478" />
+      <Map s="..|..|ColonDescendens|Fractional steady state fill level" id="479" />
+      <Map s="..|..|ColonDescendens|Intestinal transit rate (absolute)" id="480" />
+      <Map s="..|..|ColonDescendens|Volume" id="481" />
+      <Map s="LT_colsigm" id="482" />
+      <Map s="..|..|ColonDescendens|Liquid transfer rate" id="483" />
+      <Map s="..|..|Rectum|FillLevelFlag" id="484" />
+      <Map s="Neighborhoods|Lumen_colsigm_ColonSigmoid_pls|MOLECULE|Sum of active process rates" id="485" />
+      <Map s="Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|MOLECULE|Sum of active process rates" id="486" />
+      <Map s="Neighborhoods|Lumen_colsigm_ColonSigmoid_pls|MOLECULE|Sum of passive process rates" id="487" />
+      <Map s="Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|MOLECULE|Sum of passive process rates" id="488" />
+      <Map s="..|..|ColonSigmoid|Fractional steady state fill level" id="489" />
+      <Map s="..|..|ColonSigmoid|Intestinal transit rate (absolute)" id="490" />
+      <Map s="..|..|ColonSigmoid|Volume" id="491" />
+      <Map s="LT_rect" id="492" />
+      <Map s="..|..|ColonSigmoid|Liquid transfer rate" id="493" />
+      <Map s="Neighborhoods|Lumen_rect_Rectum_pls|MOLECULE|Sum of active process rates" id="494" />
+      <Map s="Neighborhoods|Lumen_rect_Rectum_cell|MOLECULE|Sum of active process rates" id="495" />
+      <Map s="Neighborhoods|Lumen_rect_Rectum_pls|MOLECULE|Sum of passive process rates" id="496" />
+      <Map s="Neighborhoods|Lumen_rect_Rectum_cell|MOLECULE|Sum of passive process rates" id="497" />
+      <Map s="..|..|Rectum|Liquid transfer rate" id="498" />
+      <Map s="LT_rec" id="499" />
+      <Map s="Neighborhoods|Stomach_pls_Stomach_int|Surface area (plasma/interstitial)" id="500" />
+      <Map s="Neighborhoods|Stomach_int_Stomach_cell|MOLECULE|Partition coefficient (interstitial/water)" id="501" />
+      <Map s="Neighborhoods|Stomach_int_Stomach_cell|MOLECULE|Partition coefficient (intracellular/water)" id="502" />
+      <Map s="..|Small intestinal transit time" id="503" />
+      <Map s="SITT" id="504" />
+      <Map s="..|Small intestinal transit time factor intercept" id="505" />
+      <Map s="P2" id="506" />
+      <Map s="..|Small intestinal transit time factor slope" id="507" />
+      <Map s="P1" id="508" />
+      <Map s="..|Fluid recirculation flow rate (incl. mucosa)" id="509" />
+      <Map s="J_iso_incl_Mucosa" id="510" />
+      <Map s="..|Mucosa|Duodenum|Fluid recirculation flow rate" id="511" />
+      <Map s="J_iso_duo" id="512" />
+      <Map s="..|Mucosa|LowerIleum|Fluid recirculation flow rate" id="513" />
+      <Map s="J_iso_lil" id="514" />
+      <Map s="..|Mucosa|LowerJejunum|Fluid recirculation flow rate" id="515" />
+      <Map s="J_iso_lje" id="516" />
+      <Map s="..|Mucosa|UpperIleum|Fluid recirculation flow rate" id="517" />
+      <Map s="J_iso_uil" id="518" />
+      <Map s="..|Mucosa|UpperJejunum|Fluid recirculation flow rate" id="519" />
+      <Map s="J_iso_uje" id="520" />
+      <Map s="..|Lymph flow rate (incl. mucosa)" id="521" />
+      <Map s="Q_lymph_incl_Mucosa" id="522" />
+      <Map s="..|Mucosa|Duodenum|Lymph flow rate" id="523" />
+      <Map s="Q_lymph_duo" id="524" />
+      <Map s="..|Mucosa|LowerIleum|Lymph flow rate" id="525" />
+      <Map s="Q_lymph_lil" id="526" />
+      <Map s="..|Mucosa|LowerJejunum|Lymph flow rate" id="527" />
+      <Map s="Q_lymph_lje" id="528" />
+      <Map s="..|Mucosa|UpperIleum|Lymph flow rate" id="529" />
+      <Map s="Q_lymph_uil" id="530" />
+      <Map s="..|Mucosa|UpperJejunum|Lymph flow rate" id="531" />
+      <Map s="Q_lymph_uje" id="532" />
+      <Map s="Neighborhoods|SmallIntestine_pls_SmallIntestine_int|Surface area (plasma/interstitial)" id="533" />
+      <Map s="..|Mucosa|Duodenum|Volume" id="534" />
+      <Map s="V_duo" id="535" />
+      <Map s="..|Mucosa|LowerIleum|Volume" id="536" />
+      <Map s="V_lil" id="537" />
+      <Map s="..|Mucosa|LowerJejunum|Volume" id="538" />
+      <Map s="V_lje" id="539" />
+      <Map s="..|Mucosa|UpperIleum|Volume" id="540" />
+      <Map s="V_uil" id="541" />
+      <Map s="..|Mucosa|UpperJejunum|Volume" id="542" />
+      <Map s="V_uje" id="543" />
+      <Map s="..|..|Volume (mucosa)" id="544" />
+      <Map s="V_Mucosa" id="545" />
+      <Map s="Neighborhoods|SmallIntestine_int_SmallIntestine_cell|MOLECULE|Partition coefficient (interstitial/water)" id="546" />
+      <Map s="Neighborhoods|SmallIntestine_int_SmallIntestine_cell|MOLECULE|Partition coefficient (intracellular/water)" id="547" />
+      <Map s="..|Fraction mucosa" id="548" />
+      <Map s="fractionMucosa" id="549" />
+      <Map s="..|..|..|..|Lumen|Duodenum|Volume (gut wall)" id="550" />
+      <Map s="V_GutWall" id="551" />
+      <Map s="..|..|..|Fluid recirculation flow rate (incl. mucosa)" id="552" />
+      <Map s="J_iso_intestine" id="553" />
+      <Map s="..|..|..|Volume" id="554" />
+      <Map s="V_intestine" id="555" />
+      <Map s="V_seg" id="556" />
+      <Map s="..|..|..|Lymph flow rate (incl. mucosa)" id="557" />
+      <Map s="Q_lymph_intestine" id="558" />
+      <Map s="Neighborhoods|Duodenum_pls_Duodenum_int|Surface area (plasma/interstitial)" id="559" />
+      <Map s="..|..|..|Blood flow rate" id="560" />
+      <Map s="..|Fraction of regional blood flow rate" id="561" />
+      <Map s="regionalFractQ" id="562" />
+      <Map s="..|..|..|Mucosa blood flow fraction" id="563" />
+      <Map s="fractQ" id="564" />
+      <Map s="Neighborhoods|Duodenum_int_Duodenum_cell|MOLECULE|Partition coefficient (interstitial/water)" id="565" />
+      <Map s="Neighborhoods|Duodenum_int_Duodenum_cell|MOLECULE|Partition coefficient (intracellular/water)" id="566" />
+      <Map s="..|..|..|..|Lumen|UpperJejunum|Volume (gut wall)" id="567" />
+      <Map s="Neighborhoods|UpperJejunum_pls_UpperJejunum_int|Surface area (plasma/interstitial)" id="568" />
+      <Map s="Neighborhoods|UpperJejunum_int_UpperJejunum_cell|MOLECULE|Partition coefficient (interstitial/water)" id="569" />
+      <Map s="Neighborhoods|UpperJejunum_int_UpperJejunum_cell|MOLECULE|Partition coefficient (intracellular/water)" id="570" />
+      <Map s="..|..|..|..|Lumen|LowerJejunum|Volume (gut wall)" id="571" />
+      <Map s="Neighborhoods|LowerJejunum_pls_LowerJejunum_int|Surface area (plasma/interstitial)" id="572" />
+      <Map s="Neighborhoods|LowerJejunum_int_LowerJejunum_cell|MOLECULE|Partition coefficient (interstitial/water)" id="573" />
+      <Map s="Neighborhoods|LowerJejunum_int_LowerJejunum_cell|MOLECULE|Partition coefficient (intracellular/water)" id="574" />
+      <Map s="..|..|..|..|Lumen|UpperIleum|Volume (gut wall)" id="575" />
+      <Map s="Neighborhoods|UpperIleum_pls_UpperIleum_int|Surface area (plasma/interstitial)" id="576" />
+      <Map s="Neighborhoods|UpperIleum_int_UpperIleum_cell|MOLECULE|Partition coefficient (interstitial/water)" id="577" />
+      <Map s="Neighborhoods|UpperIleum_int_UpperIleum_cell|MOLECULE|Partition coefficient (intracellular/water)" id="578" />
+      <Map s="..|..|..|..|Lumen|LowerIleum|Volume (gut wall)" id="579" />
+      <Map s="Neighborhoods|LowerIleum_pls_LowerIleum_int|Surface area (plasma/interstitial)" id="580" />
+      <Map s="Neighborhoods|LowerIleum_int_LowerIleum_cell|MOLECULE|Partition coefficient (interstitial/water)" id="581" />
+      <Map s="Neighborhoods|LowerIleum_int_LowerIleum_cell|MOLECULE|Partition coefficient (intracellular/water)" id="582" />
+      <Map s="..|Large intestinal transit time" id="583" />
+      <Map s="LITT" id="584" />
+      <Map s="..|Large intestinal transit time factor intercept" id="585" />
+      <Map s="..|Large intestinal transit time factor slope" id="586" />
+      <Map s="..|Mucosa|Caecum|Volume" id="587" />
+      <Map s="V_cae" id="588" />
+      <Map s="..|Mucosa|ColonAscendens|Volume" id="589" />
+      <Map s="V_ca" id="590" />
+      <Map s="..|Mucosa|ColonDescendens|Volume" id="591" />
+      <Map s="V_cd" id="592" />
+      <Map s="..|Mucosa|ColonSigmoid|Volume" id="593" />
+      <Map s="V_cs" id="594" />
+      <Map s="..|Mucosa|ColonTransversum|Volume" id="595" />
+      <Map s="V_ct" id="596" />
+      <Map s="..|Mucosa|Rectum|Volume" id="597" />
+      <Map s="V_rec" id="598" />
+      <Map s="..|Mucosa|Caecum|Fluid recirculation flow rate" id="599" />
+      <Map s="J_iso_cae" id="600" />
+      <Map s="..|Mucosa|ColonAscendens|Fluid recirculation flow rate" id="601" />
+      <Map s="J_iso_colasc" id="602" />
+      <Map s="..|Mucosa|ColonDescendens|Fluid recirculation flow rate" id="603" />
+      <Map s="J_iso_coldesc" id="604" />
+      <Map s="..|Mucosa|ColonSigmoid|Fluid recirculation flow rate" id="605" />
+      <Map s="J_iso_colsigm" id="606" />
+      <Map s="..|Mucosa|ColonTransversum|Fluid recirculation flow rate" id="607" />
+      <Map s="J_iso_coltrans" id="608" />
+      <Map s="..|Mucosa|Rectum|Fluid recirculation flow rate" id="609" />
+      <Map s="J_iso_rect" id="610" />
+      <Map s="..|Mucosa|Caecum|Lymph flow rate" id="611" />
+      <Map s="Q_lymph_cae" id="612" />
+      <Map s="..|Mucosa|ColonAscendens|Lymph flow rate" id="613" />
+      <Map s="Q_lymph_colasc" id="614" />
+      <Map s="..|Mucosa|ColonDescendens|Lymph flow rate" id="615" />
+      <Map s="Q_lymph_coldesc" id="616" />
+      <Map s="..|Mucosa|ColonSigmoid|Lymph flow rate" id="617" />
+      <Map s="Q_lymph_colsigm" id="618" />
+      <Map s="..|Mucosa|ColonTransversum|Lymph flow rate" id="619" />
+      <Map s="Q_lymph_coltrans" id="620" />
+      <Map s="..|Mucosa|Rectum|Lymph flow rate" id="621" />
+      <Map s="Q_lymph_rect" id="622" />
+      <Map s="Neighborhoods|LargeIntestine_pls_LargeIntestine_int|Surface area (plasma/interstitial)" id="623" />
+      <Map s="Neighborhoods|LargeIntestine_int_LargeIntestine_cell|MOLECULE|Partition coefficient (interstitial/water)" id="624" />
+      <Map s="Neighborhoods|LargeIntestine_int_LargeIntestine_cell|MOLECULE|Partition coefficient (intracellular/water)" id="625" />
+      <Map s="..|..|..|..|Lumen|Caecum|Volume (gut wall)" id="626" />
+      <Map s="Neighborhoods|Caecum_pls_Caecum_int|Surface area (plasma/interstitial)" id="627" />
+      <Map s="Neighborhoods|Caecum_int_Caecum_cell|MOLECULE|Partition coefficient (interstitial/water)" id="628" />
+      <Map s="Neighborhoods|Caecum_int_Caecum_cell|MOLECULE|Partition coefficient (intracellular/water)" id="629" />
+      <Map s="..|..|..|..|Lumen|ColonAscendens|Volume (gut wall)" id="630" />
+      <Map s="Neighborhoods|ColonAscendens_pls_ColonAscendens_int|Surface area (plasma/interstitial)" id="631" />
+      <Map s="Neighborhoods|ColonAscendens_int_ColonAscendens_cell|MOLECULE|Partition coefficient (interstitial/water)" id="632" />
+      <Map s="Neighborhoods|ColonAscendens_int_ColonAscendens_cell|MOLECULE|Partition coefficient (intracellular/water)" id="633" />
+      <Map s="..|..|..|..|Lumen|ColonTransversum|Volume (gut wall)" id="634" />
+      <Map s="Neighborhoods|ColonTransversum_pls_ColonTransversum_int|Surface area (plasma/interstitial)" id="635" />
+      <Map s="Neighborhoods|ColonTransversum_int_ColonTransversum_cell|MOLECULE|Partition coefficient (interstitial/water)" id="636" />
+      <Map s="Neighborhoods|ColonTransversum_int_ColonTransversum_cell|MOLECULE|Partition coefficient (intracellular/water)" id="637" />
+      <Map s="..|..|..|..|Lumen|ColonDescendens|Volume (gut wall)" id="638" />
+      <Map s="Neighborhoods|ColonDescendens_pls_ColonDescendens_int|Surface area (plasma/interstitial)" id="639" />
+      <Map s="Neighborhoods|ColonDescendens_int_ColonDescendens_cell|MOLECULE|Partition coefficient (interstitial/water)" id="640" />
+      <Map s="Neighborhoods|ColonDescendens_int_ColonDescendens_cell|MOLECULE|Partition coefficient (intracellular/water)" id="641" />
+      <Map s="..|..|..|..|Lumen|ColonSigmoid|Volume (gut wall)" id="642" />
+      <Map s="Neighborhoods|ColonSigmoid_pls_ColonSigmoid_int|Surface area (plasma/interstitial)" id="643" />
+      <Map s="Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|MOLECULE|Partition coefficient (interstitial/water)" id="644" />
+      <Map s="Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|MOLECULE|Partition coefficient (intracellular/water)" id="645" />
+      <Map s="..|..|..|..|Lumen|Rectum|Volume (gut wall)" id="646" />
+      <Map s="Neighborhoods|Rectum_pls_Rectum_int|Surface area (plasma/interstitial)" id="647" />
+      <Map s="Neighborhoods|Rectum_int_Rectum_cell|MOLECULE|Partition coefficient (interstitial/water)" id="648" />
+      <Map s="Neighborhoods|Rectum_int_Rectum_cell|MOLECULE|Partition coefficient (intracellular/water)" id="649" />
+      <Map s="Neighborhoods|Liver_pls_Liver_int|Surface area (plasma/interstitial)" id="650" />
+      <Map s="..|..|Fraction of endosomal uptake from plasma" id="651" />
+      <Map s="Liver_Parameter" id="652" />
+      <Map s="..|..|Allometric scale factor" id="653" />
+      <Map s="..|..|Density (tissue)" id="654" />
+      <Map s="..|..|Fraction of blood for sampling" id="655" />
+      <Map s="..|..|Fraction recycled to plasma" id="656" />
+      <Map s="..|..|Rate constant for endosomal uptake" id="657" />
+      <Map s="..|..|Rate constant for recycling from endosomal space" id="658" />
+      <Map s="Organism|Liver|Fraction of periportal zone" id="659" />
+      <Map s="f_periportal" id="660" />
+      <Map s="Organism|Liver|Is liver zonated" id="661" />
+      <Map s="IsLiverZonated" id="662" />
+      <Map s="Organism|Liver|Volume" id="663" />
+      <Map s="V_liv" id="664" />
+      <Map s="..|..|Flow fraction via large pores" id="665" />
+      <Map s="..|..|Fluid recirculation flow rate" id="666" />
+      <Map s="J_iso" id="667" />
+      <Map s="..|..|Hydraulic conductivity" id="668" />
+      <Map s="Hydraulic conductivity" id="669" />
+      <Map s="..|..|Lymph flow rate" id="670" />
+      <Map s="..|..|Radius (large pores)" id="671" />
+      <Map s="..|..|Radius (small pores)" id="672" />
+      <Map s="Neighborhoods|Periportal_pls_Periportal_int|Surface area (plasma/interstitial)" id="673" />
+      <Map s="..|..|Vf (lipid)" id="674" />
+      <Map s="..|..|Vf (neutral lipid)-PT" id="675" />
+      <Map s="..|..|Vf (phospholipid)-PT" id="676" />
+      <Map s="..|..|Vf (protein)" id="677" />
+      <Map s="..|..|Albumin ratio (tissue/plasma)" id="678" />
+      <Map s="..|..|Albumin ratio (tissue/plasma)-PT" id="679" />
+      <Map s="..|..|Lipoprotein ratio (tissue/plasma)" id="680" />
+      <Map s="..|..|Microsomal protein mass/g tissue" id="681" />
+      <Map s="Mass per tissue" id="682" />
+      <Map s="..|..|Number of cells/g tissue" id="683" />
+      <Map s="Count per mass" id="684" />
+      <Map s="..|..|Vf (water)" id="685" />
+      <Map s="..|..|Vf (water)-PT" id="686" />
+      <Map s="..|..|Vf (neutral lipid)-RR" id="687" />
+      <Map s="..|..|Vf (neutral lipid)-WS" id="688" />
+      <Map s="..|..|Vf (neutral phospholipid)-RR" id="689" />
+      <Map s="..|..|Vf (neutral phospholipid, plasma)-WS" id="690" />
+      <Map s="..|..|Vf (extracellular water)-RR" id="691" />
+      <Map s="..|..|Vf (protein)-WS" id="692" />
+      <Map s="..|..|Vf (intracellular water)-RR" id="693" />
+      <Map s="..|..|Vf (water)-WS" id="694" />
+      <Map s="..|..|Acidic phospholipids [mg/g] - RR" id="695" />
+      <Map s="..|..|Vf (acidic phospholipids)-WS" id="696" />
+      <Map s="..|..|Specific blood flow rate" id="697" />
+      <Map s="..|..|Blood flow rate" id="698" />
+      <Map s="Neighborhoods|Periportal_int_Periportal_cell|MOLECULE|Partition coefficient (interstitial/water)" id="699" />
+      <Map s="Organism|Liver|Intracellular|pH" id="700" />
+      <Map s="pH_cell_Liver" id="701" />
+      <Map s="Neighborhoods|Periportal_int_Periportal_cell|MOLECULE|Partition coefficient (intracellular/water)" id="702" />
+      <Map s="Neighborhoods|Pericentral_pls_Pericentral_int|Surface area (plasma/interstitial)" id="703" />
+      <Map s="Neighborhoods|Lung_pls_Lung_int|Surface area (plasma/interstitial)" id="704" />
+      <Map s="Neighborhoods|Lung_int_Lung_cell|MOLECULE|Partition coefficient (interstitial/water)" id="705" />
+      <Map s="Neighborhoods|Lung_int_Lung_cell|MOLECULE|Partition coefficient (intracellular/water)" id="706" />
+      <Map s="Neighborhoods|Muscle_pls_Muscle_int|Surface area (plasma/interstitial)" id="707" />
+      <Map s="Neighborhoods|Muscle_int_Muscle_cell|MOLECULE|Partition coefficient (interstitial/water)" id="708" />
+      <Map s="Neighborhoods|Muscle_int_Muscle_cell|MOLECULE|Partition coefficient (intracellular/water)" id="709" />
+      <Map s="Neighborhoods|Pancreas_pls_Pancreas_int|Surface area (plasma/interstitial)" id="710" />
+      <Map s="Neighborhoods|Pancreas_int_Pancreas_cell|MOLECULE|Partition coefficient (interstitial/water)" id="711" />
+      <Map s="Neighborhoods|Pancreas_int_Pancreas_cell|MOLECULE|Partition coefficient (intracellular/water)" id="712" />
+      <Map s="Organism|LargeIntestine|Lymph flow rate (incl. mucosa)" id="713" />
+      <Map s="Q_Lymph_lin_incl_Mucosa" id="714" />
+      <Map s="Organism|Pancreas|Lymph flow rate" id="715" />
+      <Map s="Q_Lymph_pan" id="716" />
+      <Map s="Organism|SmallIntestine|Lymph flow rate (incl. mucosa)" id="717" />
+      <Map s="Q_Lymph_sin_incl_Mucosa" id="718" />
+      <Map s="Organism|Spleen|Lymph flow rate" id="719" />
+      <Map s="Q_Lymph_spl" id="720" />
+      <Map s="Organism|Stomach|Lymph flow rate" id="721" />
+      <Map s="Q_Lymph_sto" id="722" />
+      <Map s="Organism|LargeIntestine|Blood flow rate" id="723" />
+      <Map s="Q_lin" id="724" />
+      <Map s="Organism|Pancreas|Blood flow rate" id="725" />
+      <Map s="Q_pan" id="726" />
+      <Map s="Organism|SmallIntestine|Blood flow rate" id="727" />
+      <Map s="Q_sin" id="728" />
+      <Map s="Organism|Spleen|Blood flow rate" id="729" />
+      <Map s="Q_spl" id="730" />
+      <Map s="Organism|Stomach|Blood flow rate" id="731" />
+      <Map s="Q_sto" id="732" />
+      <Map s="Neighborhoods|Skin_pls_Skin_int|Surface area (plasma/interstitial)" id="733" />
+      <Map s="Neighborhoods|Skin_int_Skin_cell|MOLECULE|Partition coefficient (interstitial/water)" id="734" />
+      <Map s="Neighborhoods|Skin_int_Skin_cell|MOLECULE|Partition coefficient (intracellular/water)" id="735" />
+      <Map s="Neighborhoods|Spleen_pls_Spleen_int|Surface area (plasma/interstitial)" id="736" />
+      <Map s="Neighborhoods|Spleen_int_Spleen_cell|MOLECULE|Partition coefficient (interstitial/water)" id="737" />
+      <Map s="Neighborhoods|Spleen_int_Spleen_cell|MOLECULE|Partition coefficient (intracellular/water)" id="738" />
+      <Map s="Organism|EndogenousIgG|Endosome|Volume" id="739" />
+      <Map s="Volume_EndogenIgG_endosom" id="740" />
+      <Map s="Organism|EndogenousIgG|Interstitial|Volume" id="741" />
+      <Map s="Volume_EndogenIgG_int" id="742" />
+      <Map s="Organism|EndogenousIgG|Plasma|Volume" id="743" />
+      <Map s="Volume_EndogenIgG_pls" id="744" />
+      <Map s="Organism|EndogenousIgG|Fraction of endosomal uptake from plasma" id="745" />
+      <Map s="f_uptake_vas" id="746" />
+      <Map s="Organism|EndogenousIgG|Rate constant for endosomal uptake" id="747" />
+      <Map s="Organism|EndogenousIgG|f_membrane_int" id="748" />
+      <Map s="f_mem_int" id="749" />
+      <Map s="V_end" id="750" />
+      <Map s="Organism|EndogenousIgG|f_membrane_pls" id="751" />
+      <Map s="f_mem_pls" id="752" />
+      <Map s="..|Fluid recirculation flow rate" id="753" />
+      <Map s="..|Reflection coefficient (large pores)" id="754" />
+      <Map s="sigma_l" id="755" />
+      <Map s="..|Reflection coefficient (small pores)" id="756" />
+      <Map s="sigma_s" id="757" />
+      <Map s="..|igg_k_diff_pls" id="758" />
+      <Map s="k_diff_pls" id="759" />
+      <Map s="..|P (large endothelial pores)" id="760" />
+      <Map s="P_endothelial_l" id="761" />
+      <Map s="..|P (small endothelial pores)" id="762" />
+      <Map s="P_endothelial_s" id="763" />
+      <Map s="..|Peclet number (large pores)" id="764" />
+      <Map s="Pe_l" id="765" />
+      <Map s="..|Peclet number (small pores)" id="766" />
+      <Map s="Pe_s" id="767" />
+      <Map s="Neighborhoods|EndogenousIgG_int_EndogenousIgG_pls|Surface area (plasma/interstitial)" id="768" />
+      <Map s="Organism|EndogenousIgG|Endosome|Specific endosomal clearance" id="769" />
+      <Map s="CLspec" id="770" />
+      <Map s="Organism|EndogenousIgG|Fraction recycled to plasma" id="771" />
+      <Map s="f_rec_vas" id="772" />
+      <Map s="Organism|EndogenousIgG|Rate constant for recycling from endosomal space" id="773" />
+      <Map s="..|IgG_kdeg" id="774" />
+      <Map s="kdeg" id="775" />
+      <Map s="..|IgG_kei" id="776" />
+      <Map s="kei" id="777" />
+      <Map s="..|IgG_kep" id="778" />
+      <Map s="kep" id="779" />
+      <Map s="..|IgG_kie" id="780" />
+      <Map s="kie" id="781" />
+      <Map s="..|IgG_kpe" id="782" />
+      <Map s="kpe" id="783" />
+      <Map s="..|Kd (FcRn, endogenous IgG) in endosomal space" id="784" />
+      <Map s="Kd" id="785" />
+      <Map s="Ql" id="786" />
+      <Map s="..|igg_k_conv" id="787" />
+      <Map s="k_conv" id="788" />
+      <Map s="..|igg_k_diff_int" id="789" />
+      <Map s="k_diff_int" id="790" />
+      <Map s="..|kass (FcRn, endogenous IgG)" id="791" />
+      <Map s="ka" id="792" />
+      <Map s="Second order rate constant" id="793" />
+      <Map s="..|Endosome|Volume" id="794" />
+      <Map s="Ve" id="795" />
+      <Map s="Organism|EndogenousIgG|Endosome|Start concentration of free FcRn (endosome)" id="796" />
+      <Map s="FcRnEnd" id="797" />
+      <Map s="Organism|EndogenousIgG|Plasma|Start concentration of free endogenous IgG (plasma)" id="798" />
+      <Map s="Cpl" id="799" />
+      <Map s="..|Hydraulic conductivity" id="800" />
+      <Map s="Lp" id="801" />
+      <Map s="..|Radius (large pores)" id="802" />
+      <Map s="r" id="803" />
+      <Map s="..|Radius ratio (solute/large pores)" id="804" />
+      <Map s="gamma" id="805" />
+      <Map s="Organism|Na" id="806" />
+      <Map s="Na" id="807" />
+      <Map s="Inversed mol" id="808" />
+      <Map s="Organism|R*T" id="809" />
+      <Map s="RT" id="810" />
+      <Map s="Organism|EndogenousIgG|Radius (endogeneous IgG)" id="811" />
+      <Map s="a_e_endog" id="812" />
+      <Map s="..|Radius (small pores)" id="813" />
+      <Map s="..|Radius ratio (solute/small pores)" id="814" />
+      <Map s="r_l" id="815" />
+      <Map s="r_s" id="816" />
+      <Map s="Organism|Bone|Fluid recirculation flow rate" id="817" />
+      <Map s="J_iso_bon" id="818" />
+      <Map s="Organism|Brain|Fluid recirculation flow rate" id="819" />
+      <Map s="J_iso_brn" id="820" />
+      <Map s="Organism|Fat|Fluid recirculation flow rate" id="821" />
+      <Map s="J_iso_fat" id="822" />
+      <Map s="Organism|Gonads|Fluid recirculation flow rate" id="823" />
+      <Map s="J_iso_tes" id="824" />
+      <Map s="Organism|Heart|Fluid recirculation flow rate" id="825" />
+      <Map s="J_iso_hrt" id="826" />
+      <Map s="Organism|Kidney|Fluid recirculation flow rate" id="827" />
+      <Map s="J_iso_kid" id="828" />
+      <Map s="Organism|LargeIntestine|Fluid recirculation flow rate (incl. mucosa)" id="829" />
+      <Map s="J_iso_lin" id="830" />
+      <Map s="Organism|Liver|Fluid recirculation flow rate" id="831" />
+      <Map s="J_iso_liv" id="832" />
+      <Map s="Organism|Lung|Fluid recirculation flow rate" id="833" />
+      <Map s="J_iso_lng" id="834" />
+      <Map s="Organism|Muscle|Fluid recirculation flow rate" id="835" />
+      <Map s="J_iso_mus" id="836" />
+      <Map s="Organism|Pancreas|Fluid recirculation flow rate" id="837" />
+      <Map s="J_iso_pan" id="838" />
+      <Map s="Organism|Skin|Fluid recirculation flow rate" id="839" />
+      <Map s="J_iso_skn" id="840" />
+      <Map s="Organism|SmallIntestine|Fluid recirculation flow rate (incl. mucosa)" id="841" />
+      <Map s="J_iso_sin" id="842" />
+      <Map s="Organism|Spleen|Fluid recirculation flow rate" id="843" />
+      <Map s="J_iso_spl" id="844" />
+      <Map s="Organism|Stomach|Fluid recirculation flow rate" id="845" />
+      <Map s="J_iso_sto" id="846" />
+      <Map s="Organism|Bone|Lymph flow rate" id="847" />
+      <Map s="Q_lymph_bon" id="848" />
+      <Map s="Organism|Brain|Lymph flow rate" id="849" />
+      <Map s="Q_lymph_brn" id="850" />
+      <Map s="Organism|Fat|Lymph flow rate" id="851" />
+      <Map s="Q_lymph_fat" id="852" />
+      <Map s="Organism|Gonads|Lymph flow rate" id="853" />
+      <Map s="Q_lymph_tes" id="854" />
+      <Map s="Organism|Heart|Lymph flow rate" id="855" />
+      <Map s="Q_lymph_hrt" id="856" />
+      <Map s="Organism|Kidney|Lymph flow rate" id="857" />
+      <Map s="Q_lymph_kid" id="858" />
+      <Map s="Q_lymph_lin" id="859" />
+      <Map s="Organism|Liver|Lymph flow rate" id="860" />
+      <Map s="Q_lymph_liv" id="861" />
+      <Map s="Organism|Lung|Lymph flow rate" id="862" />
+      <Map s="Q_lymph_lng" id="863" />
+      <Map s="Organism|Muscle|Lymph flow rate" id="864" />
+      <Map s="Q_lymph_mus" id="865" />
+      <Map s="Q_lymph_pan" id="866" />
+      <Map s="Organism|Skin|Lymph flow rate" id="867" />
+      <Map s="Q_lymph_skn" id="868" />
+      <Map s="Q_lymph_sin" id="869" />
+      <Map s="Q_lymph_spl" id="870" />
+      <Map s="Q_lymph_sto" id="871" />
+      <Map s="Organism|EndogenousIgG|Kd (FcRn, endogenous IgG) in plasma/interstitial" id="872" />
+      <Map s="Kd_FcRn_LigandEndo" id="873" />
+      <Map s="V_colasc" id="874" />
+      <Map s="V_coldesc" id="875" />
+      <Map s="V_colsigm" id="876" />
+      <Map s="V_coltrans" id="877" />
+      <Map s="V_rect" id="878" />
+      <Map s="V_bon" id="879" />
+      <Map s="V_brn" id="880" />
+      <Map s="V_fat" id="881" />
+      <Map s="V_tes" id="882" />
+      <Map s="V_hrt" id="883" />
+      <Map s="V_kid" id="884" />
+      <Map s="V_lin" id="885" />
+      <Map s="Organism|Liver|Plasma|Volume" id="886" />
+      <Map s="V_lng" id="887" />
+      <Map s="V_mus" id="888" />
+      <Map s="V_pan" id="889" />
+      <Map s="V_skn" id="890" />
+      <Map s="V_sin" id="891" />
+      <Map s="V_spl" id="892" />
+      <Map s="V_sto" id="893" />
+      <Map s="Organism|LargeIntestine|Mucosa|Caecum|Interstitial|Volume" id="894" />
+      <Map s="Organism|LargeIntestine|Mucosa|ColonAscendens|Interstitial|Volume" id="895" />
+      <Map s="Organism|LargeIntestine|Mucosa|ColonDescendens|Interstitial|Volume" id="896" />
+      <Map s="Organism|LargeIntestine|Mucosa|ColonSigmoid|Interstitial|Volume" id="897" />
+      <Map s="Organism|LargeIntestine|Mucosa|ColonTransversum|Interstitial|Volume" id="898" />
+      <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Interstitial|Volume" id="899" />
+      <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Interstitial|Volume" id="900" />
+      <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Interstitial|Volume" id="901" />
+      <Map s="Organism|LargeIntestine|Mucosa|Rectum|Interstitial|Volume" id="902" />
+      <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Interstitial|Volume" id="903" />
+      <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Interstitial|Volume" id="904" />
+      <Map s="Organism|Bone|Interstitial|Volume" id="905" />
+      <Map s="Organism|Brain|Interstitial|Volume" id="906" />
+      <Map s="Organism|Fat|Interstitial|Volume" id="907" />
+      <Map s="Organism|Gonads|Interstitial|Volume" id="908" />
+      <Map s="Organism|Heart|Interstitial|Volume" id="909" />
+      <Map s="Organism|Kidney|Interstitial|Volume" id="910" />
+      <Map s="Organism|LargeIntestine|Interstitial|Volume" id="911" />
+      <Map s="Organism|Liver|Interstitial|Volume" id="912" />
+      <Map s="Organism|Lung|Interstitial|Volume" id="913" />
+      <Map s="Organism|Muscle|Interstitial|Volume" id="914" />
+      <Map s="Organism|Pancreas|Interstitial|Volume" id="915" />
+      <Map s="Organism|Skin|Interstitial|Volume" id="916" />
+      <Map s="Organism|SmallIntestine|Interstitial|Volume" id="917" />
+      <Map s="Organism|Spleen|Interstitial|Volume" id="918" />
+      <Map s="Organism|Stomach|Interstitial|Volume" id="919" />
+      <Map s="Organism|EndogenousIgG|Kd (FcRn, endogenous IgG) in endosomal space" id="920" />
+      <Map s="Organism|Specific clearance (endosome)" id="921" />
+      <Map s="CLspec_endosomal_global" id="922" />
+      <Map s="Organism|LargeIntestine|Mucosa|Caecum|Endosome|Volume" id="923" />
+      <Map s="Organism|LargeIntestine|Mucosa|ColonAscendens|Endosome|Volume" id="924" />
+      <Map s="Organism|LargeIntestine|Mucosa|ColonDescendens|Endosome|Volume" id="925" />
+      <Map s="Organism|LargeIntestine|Mucosa|ColonSigmoid|Endosome|Volume" id="926" />
+      <Map s="Organism|LargeIntestine|Mucosa|ColonTransversum|Endosome|Volume" id="927" />
+      <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Endosome|Volume" id="928" />
+      <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Endosome|Volume" id="929" />
+      <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Endosome|Volume" id="930" />
+      <Map s="Organism|LargeIntestine|Mucosa|Rectum|Endosome|Volume" id="931" />
+      <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Endosome|Volume" id="932" />
+      <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Endosome|Volume" id="933" />
+      <Map s="Organism|Bone|Endosome|Volume" id="934" />
+      <Map s="Organism|Brain|Endosome|Volume" id="935" />
+      <Map s="Organism|Fat|Endosome|Volume" id="936" />
+      <Map s="Organism|Gonads|Endosome|Volume" id="937" />
+      <Map s="Organism|Heart|Endosome|Volume" id="938" />
+      <Map s="Organism|Kidney|Endosome|Volume" id="939" />
+      <Map s="Organism|LargeIntestine|Endosome|Volume" id="940" />
+      <Map s="Organism|Liver|Endosome|Volume" id="941" />
+      <Map s="Organism|Lung|Endosome|Volume" id="942" />
+      <Map s="Organism|Muscle|Endosome|Volume" id="943" />
+      <Map s="Organism|Pancreas|Endosome|Volume" id="944" />
+      <Map s="Organism|Skin|Endosome|Volume" id="945" />
+      <Map s="Organism|SmallIntestine|Endosome|Volume" id="946" />
+      <Map s="Organism|Spleen|Endosome|Volume" id="947" />
+      <Map s="Organism|Stomach|Endosome|Volume" id="948" />
+      <Map s="Organism|Saliva|Volume" id="949" />
+      <Map s="V_slv" id="950" />
+      <Map s="FIRST_NEIGHBOR|..|Volume" id="951" />
+      <Map s="Organism|Surface/Volume ratio (blood cells)" id="952" />
+      <Map s="A_to_V_bc" id="953" />
+      <Map s="..|P_int_cell_factor" id="954" />
+      <Map s="P_int_cell_factor" id="955" />
+      <Map s="..|P_cell_int_factor" id="956" />
+      <Map s="P_cell_int_factor" id="957" />
+      <Map s="..|P (interstitial-&gt;intracellular)" id="958" />
+      <Map s="P_int_cell" id="959" />
+      <Map s="..|..|Surface area (interstitial/intracellular)" id="960" />
+      <Map s="SA" id="961" />
+      <Map s="..|P (intracellular-&gt;interstitial)" id="962" />
+      <Map s="P_cell_int" id="963" />
+      <Map s="..|Partition coefficient (intracellular/plasma)" id="964" />
+      <Map s="K_cell_pls" id="965" />
+      <Map s="FIRST_NEIGHBOR|..|Fraction vascular" id="966" />
+      <Map s="f_vas_org" id="967" />
+      <Map s="Organism|SA proportionality factor" id="968" />
+      <Map s="MOLECULE|Radius (solute)" id="969" />
+      <Map s="a_e" id="970" />
+      <Map s="FIRST_NEIGHBOR|..|Flow fraction via large pores" id="971" />
+      <Map s="FIRST_NEIGHBOR|..|Hydraulic conductivity" id="972" />
+      <Map s="FIRST_NEIGHBOR|..|Radius (large pores)" id="973" />
+      <Map s="FIRST_NEIGHBOR|..|Radius (small pores)" id="974" />
+      <Map s="FIRST_NEIGHBOR|..|Fluid recirculation flow rate" id="975" />
+      <Map s="FIRST_NEIGHBOR|..|Lymph flow rate" id="976" />
+      <Map s="..|..|Surface area (plasma/interstitial)" id="977" />
+      <Map s="FIRST_NEIGHBOR|Effective surface area" id="978" />
+      <Map s="Aeff" id="979" />
+      <Map s="SECOND_NEIGHBOR|MOLECULE|Concentration" id="980" />
+      <Map s="DrugMucosa" id="981" />
+      <Map s="FIRST_NEIGHBOR|MOLECULE|Effective concentration in lumen" id="982" />
+      <Map s="EffectiveLumenConcentration" id="983" />
+      <Map s="MOLECULE|Intestinal permeability (paracellular)" id="984" />
+      <Map s="P_int_para" id="985" />
+      <Map s="FIRST_NEIGHBOR|..|OralApplicationsEnabled" id="986" />
+      <Map s="FIRST_NEIGHBOR|..|Paracellular absorption sink condition" id="987" />
+      <Map s="SinkCondition_para" id="988" />
+      <Map s="MOLECULE|Intestinal permeability (transcellular)" id="989" />
+      <Map s="NEIGHBORHOOD|MOLECULE|P_int_trans_cell_lum_factor" id="990" />
+      <Map s="P_int_trans_cell_lum_factor" id="991" />
+      <Map s="NEIGHBORHOOD|MOLECULE|P_int_trans_lum_cell_factor" id="992" />
+      <Map s="P_int_trans_lum_cell_factor" id="993" />
+      <Map s="FIRST_NEIGHBOR|..|Transcellular absorption sink condition" id="994" />
+      <Map s="SinkCondition_trans" id="995" />
+      <Map s="..|pKa_pH_WS_cell_K1" id="996" />
+      <Map s="..|pKa_pH_WS_cell_K2" id="997" />
+      <Map s="..|pKa_pH_WS_cell_K3" id="998" />
+      <Map s="..|pKa_pH_WS_cell_K4" id="999" />
+      <Map s="..|pKa_pH_WS_cell_K5" id="1000" />
+      <Map s="..|pKa_pH_WS_cell_K6" id="1001" />
+      <Map s="..|pKa_pH_WS_cell_K7" id="1002" />
+      <Map s="..|pKa_pH_WS_cell_K8" id="1003" />
+      <Map s="MOLECULE|Use pH- and pKa-dependent penalty factor for charged molecule fraction" id="1004" />
+      <Map s="UsePenaltyFactor" id="1005" />
+      <Map s="MOLECULE|base_For_Pint_Factor" id="1006" />
+      <Map s="Neighborhoods|UpperJejunum_int_UpperJejunum_cell|MOLECULE|Partition coefficient (intracellular/plasma)" id="1007" />
+      <Map s="SECOND_NEIGHBOR|pH" id="1008" />
+      <Map s="..|pKa_pH_WS_cell_F1" id="1009" />
+      <Map s="..|pKa_pH_WS_cell_F2" id="1010" />
+      <Map s="..|pKa_pH_WS_cell_F3" id="1011" />
+      <Map s="FIRST_NEIGHBOR|pH" id="1012" />
+      <Map s="FIRST_NEIGHBOR|MOLECULE|Concentration" id="1013" />
+      <Map s="C_pls" id="1014" />
+      <Map s="FIRST_NEIGHBOR|..|Blood flow rate" id="1015" />
+      <Map s="C_bc" id="1016" />
+      <Map s="Neighborhoods|LowerJejunum_int_LowerJejunum_cell|MOLECULE|Partition coefficient (intracellular/plasma)" id="1017" />
+      <Map s="Organism|Lumen|Caecum|MOLECULE|Oral mass absorbed segment" id="1018" />
+      <Map s="MAbs_cae" id="1019" />
+      <Map s="Organism|Lumen|ColonAscendens|MOLECULE|Oral mass absorbed segment" id="1020" />
+      <Map s="MAbs_colasc" id="1021" />
+      <Map s="Organism|Lumen|ColonDescendens|MOLECULE|Oral mass absorbed segment" id="1022" />
+      <Map s="MAbs_coldesc" id="1023" />
+      <Map s="Organism|Lumen|ColonSigmoid|MOLECULE|Oral mass absorbed segment" id="1024" />
+      <Map s="MAbs_colsigm" id="1025" />
+      <Map s="Organism|Lumen|ColonTransversum|MOLECULE|Oral mass absorbed segment" id="1026" />
+      <Map s="MAbs_coltrans" id="1027" />
+      <Map s="Organism|Lumen|Duodenum|MOLECULE|Oral mass absorbed segment" id="1028" />
+      <Map s="MAbs_duo" id="1029" />
+      <Map s="Organism|Lumen|LowerIleum|MOLECULE|Oral mass absorbed segment" id="1030" />
+      <Map s="MAbs_lil" id="1031" />
+      <Map s="Organism|Lumen|LowerJejunum|MOLECULE|Oral mass absorbed segment" id="1032" />
+      <Map s="MAbs_lje" id="1033" />
+      <Map s="Organism|Lumen|Rectum|MOLECULE|Oral mass absorbed segment" id="1034" />
+      <Map s="MAbs_rect" id="1035" />
+      <Map s="Organism|Lumen|UpperIleum|MOLECULE|Oral mass absorbed segment" id="1036" />
+      <Map s="MAbs_uil" id="1037" />
+      <Map s="Organism|Lumen|UpperJejunum|MOLECULE|Oral mass absorbed segment" id="1038" />
+      <Map s="MAbs_uje" id="1039" />
+      <Map s="Neighborhoods|UpperIleum_int_UpperIleum_cell|MOLECULE|Partition coefficient (intracellular/plasma)" id="1040" />
+      <Map s="Organism|SmallIntestine|Volume (mucosa)" id="1041" />
+      <Map s="FIRST_NEIGHBOR|..|Volume (mucosa)" id="1042" />
+      <Map s="SECOND_NEIGHBOR|..|Blood flow rate" id="1043" />
+      <Map s="SECOND_NEIGHBOR|..|Lymph flow rate" id="1044" />
+      <Map s="Neighborhoods|LowerIleum_int_LowerIleum_cell|MOLECULE|Partition coefficient (intracellular/plasma)" id="1045" />
+      <Map s="Organism|LargeIntestine|Volume (mucosa)" id="1046" />
+      <Map s="Neighborhoods|Liver_int_Liver_cell|Surface area (interstitial/intracellular)" id="1047" />
+      <Map s="SA_int_cell" id="1048" />
+      <Map s="Neighborhoods|Liver_pls_Liver_bc|Surface area (blood cells/plasma)" id="1049" />
+      <Map s="SA_pls_bc" id="1050" />
+      <Map s="Neighborhoods|Rectum_int_Rectum_cell|MOLECULE|Partition coefficient (intracellular/plasma)" id="1051" />
+      <Map s="SA_pls_int_bon" id="1052" />
+      <Map s="SA_pls_int_brn" id="1053" />
+      <Map s="SA_pls_int_fat" id="1054" />
+      <Map s="SA_pls_int_tes" id="1055" />
+      <Map s="SA_pls_int_hrt" id="1056" />
+      <Map s="SA_pls_int_kid" id="1057" />
+      <Map s="SA_pls_int_lin" id="1058" />
+      <Map s="SA_pls_int_liv" id="1059" />
+      <Map s="SA_pls_int_lng" id="1060" />
+      <Map s="SA_pls_int_mus" id="1061" />
+      <Map s="SA_pls_int_pan" id="1062" />
+      <Map s="SA_pls_int_skn" id="1063" />
+      <Map s="SA_pls_int_sin" id="1064" />
+      <Map s="SA_pls_int_spl" id="1065" />
+      <Map s="SA_pls_int_sto" id="1066" />
+      <Map s="..|SalivaPlasmaRatio" id="1067" />
+      <Map s="R" id="1068" />
+      <Map s="SECOND_NEIGHBOR|pH (saliva)" id="1069" />
+      <Map s="pH_slv" id="1070" />
+      <Map s="Organism|pH (plasma)" id="1071" />
+      <Map s="pH_PLS" id="1072" />
+      <Map s="Organism|Lumen|Duodenum|Effective surface area" id="1073" />
+      <Map s="Organism|Lumen|Duodenum|Microvilli factor" id="1074" />
+      <Map s="MicrovilliFactor" id="1075" />
+      <Map s="MOLECULE|Mucosa permeability scale factor (transcellular)" id="1076" />
+      <Map s="P_int_scalefactor" id="1077" />
+      <Map s="Organism|Lumen|UpperJejunum|Effective surface area" id="1078" />
+      <Map s="Organism|Lumen|UpperJejunum|Microvilli factor" id="1079" />
+      <Map s="Organism|Lumen|LowerJejunum|Effective surface area" id="1080" />
+      <Map s="Organism|Lumen|LowerJejunum|Microvilli factor" id="1081" />
+      <Map s="Organism|Lumen|UpperIleum|Effective surface area" id="1082" />
+      <Map s="Organism|Lumen|UpperIleum|Microvilli factor" id="1083" />
+      <Map s="Organism|Lumen|LowerIleum|Effective surface area" id="1084" />
+      <Map s="Organism|Lumen|LowerIleum|Microvilli factor" id="1085" />
+      <Map s="Organism|Lumen|Caecum|Effective surface area" id="1086" />
+      <Map s="Organism|Lumen|Caecum|Microvilli factor" id="1087" />
+      <Map s="Organism|Lumen|ColonAscendens|Effective surface area" id="1088" />
+      <Map s="Organism|Lumen|ColonAscendens|Microvilli factor" id="1089" />
+      <Map s="Organism|Lumen|ColonTransversum|Effective surface area" id="1090" />
+      <Map s="Organism|Lumen|ColonTransversum|Microvilli factor" id="1091" />
+      <Map s="Organism|Lumen|ColonDescendens|Effective surface area" id="1092" />
+      <Map s="Organism|Lumen|ColonDescendens|Microvilli factor" id="1093" />
+      <Map s="Organism|Lumen|ColonSigmoid|Effective surface area" id="1094" />
+      <Map s="Organism|Lumen|ColonSigmoid|Microvilli factor" id="1095" />
+      <Map s="Organism|Lumen|Rectum|Effective surface area" id="1096" />
+      <Map s="Organism|Lumen|Rectum|Microvilli factor" id="1097" />
+      <Map s="Neighborhoods|Duodenum_int_Duodenum_cell|MOLECULE|Partition coefficient (intracellular/plasma)" id="1098" />
+      <Map s="Neighborhoods|Caecum_int_Caecum_cell|MOLECULE|Partition coefficient (intracellular/plasma)" id="1099" />
+      <Map s="Neighborhoods|ColonAscendens_int_ColonAscendens_cell|MOLECULE|Partition coefficient (intracellular/plasma)" id="1100" />
+      <Map s="Neighborhoods|ColonTransversum_int_ColonTransversum_cell|MOLECULE|Partition coefficient (intracellular/plasma)" id="1101" />
+      <Map s="Neighborhoods|ColonDescendens_int_ColonDescendens_cell|MOLECULE|Partition coefficient (intracellular/plasma)" id="1102" />
+      <Map s="Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|MOLECULE|Partition coefficient (intracellular/plasma)" id="1103" />
+      <Map s="Mean" id="1104" />
+      <Map s="Deviation" id="1105" />
+      <Map s="GeometricDeviation" id="1106" />
     </StringMap>
   </FormulaCache>
 </SpatialStructure>
\ No newline at end of file
diff --git a/src/Data/Templates/Human Standard.pkml b/src/Data/Templates/Human Standard.pkml
index ec35a5436..68d7e6e8f 100644
--- a/src/Data/Templates/Human Standard.pkml	
+++ b/src/Data/Templates/Human Standard.pkml	
@@ -1,360 +1,363 @@
 <?xml version="1.0" encoding="utf-8"?>
-<SpatialStructure id="gemRyp6GPke2jMedStCAWw" name="Human Standard" icon="SpatialStructure" bbVersion="0" version="13">
-  <Creation createdAt="5248308555517281915" createdBy="EZZJY" creationMode="New" origin="PKSim" version="7.3.0" internalVersion="74" />
-  <GlobalMoleculeDependentProperties id="pO2308RpLUO_TsRFwl_sZQ" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+<SpatialStructure id="aK5ynJ3auk21UVdMLMLkQg" name="Human Standard" icon="SpatialStructure" bbVersion="0" version="14">
+  <Creation createdAt="5248852327622551362" createdBy="Michael" creationMode="New" origin="PKSim" version="9.0" internalVersion="77" />
+  <GlobalMoleculeDependentProperties id="YNBzQJJEikK3rr4qICxjPw" name="MoleculeProperties" mode="Logical" containerType="Molecule">
     <Children>
-      <Parameter id="jLrCcIZd-U6PBBJi2tyjVg" name="Mucosa permeability scale factor (transcellular)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_MucosaPermeabilityScaleFactor_trans" buildMode="Global" isDefault="1">
+      <Parameter id="gB3_s2edXEKz185osHKUzA" name="Default Intestinal permeability (transcellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_default" buildMode="Global" isDefault="1" displayUnit="cm/min">
         <Info min="0" flag="52" seq="1" ref="0" bb="2" group="75" />
       </Parameter>
-      <Parameter id="s9hVCbf1l0Gk_6GEX73_QQ" name="Partition coefficient (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" buildMode="Global" isDefault="1">
-        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="67" />
+      <Parameter id="oS9EyYtFJUyYXOXfRy3h9w" name="Intestinal permeability (paracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Global" isDefault="1" value="0" displayUnit="cm/min">
+        <ValueOrigin id="47" source="Publication" description="Kuepfer, L., Niederalt, C., Wendl, T., Schlender, J.-F., Willmann, S., Lippert, J., Block, M., Eissing, T. and Teutonico, D. (2016), Applied Concepts in PBPK Modeling: How to Build a PBPK/PD Model. CPT Pharmacometrics Syst. Pharmacol., 5: 516–531. doi:10." />
+        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="75" />
       </Parameter>
-      <Parameter id="ARbc22EU0Eyh2wB5G6pQZQ" name="P_pls_bc_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" buildMode="Global" isDefault="1">
-        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+      <Parameter id="weFMxQThv0CKbWBkOP2I3A" name="Intestinal permeability (transcellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int" buildMode="Global" isDefault="1" displayUnit="cm/min">
+        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="75" />
       </Parameter>
-      <Parameter id="jOJ0ClalBEW9SViVAfIY8w" name="P_bc_pls_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" buildMode="Global" isDefault="1">
-        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+      <Parameter id="O5FVaI0jdEyGI1cEsUWWCA" name="Mucosa permeability scale factor (transcellular)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_MucosaPermeabilityScaleFactor_trans" buildMode="Global" isDefault="1">
+        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="75" />
       </Parameter>
-      <Parameter id="kpC_mGKyCkufQHgO0-8KwA" name="P (blood cells-&gt;plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_rbc_pls" buildMode="Global" isDefault="1" displayUnit="cm/min">
+      <Parameter id="gDTHTYfP8U-nB9U8WYWmKA" name="P (blood cells-&gt;plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_rbc_pls" buildMode="Global" isDefault="1" displayUnit="cm/min">
         <Info min="0" flag="122" seq="1" ref="0" bb="2" group="75" />
       </Parameter>
-      <Parameter id="HmRwYto_F0y4bmG3knrwPg" name="Intestinal permeability (transcellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int" buildMode="Global" isDefault="1" displayUnit="cm/min">
+      <Parameter id="lFi7GyKZVUOU39m9DbecQQ" name="P (plasma-&gt;blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_pls_rbc" buildMode="Global" isDefault="1" displayUnit="cm/min">
         <Info min="0" flag="122" seq="1" ref="0" bb="2" group="75" />
       </Parameter>
-      <Parameter id="reOf4_u7NUu8F-QQ1n2XoA" name="Intestinal permeability (paracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Global" isDefault="1" value="0" displayUnit="cm/min">
-        <ValueOrigin id="47" source="Publication" description="Kuepfer, L., Niederalt, C., Wendl, T., Schlender, J.-F., Willmann, S., Lippert, J., Block, M., Eissing, T. and Teutonico, D. (2016), Applied Concepts in PBPK Modeling: How to Build a PBPK/PD Model. CPT Pharmacometrics Syst. Pharmacol., 5: 516–531. doi:10." />
-        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="75" />
+      <Parameter id="2mUUQi_MxUC_JShWtitOCQ" name="P_bc_pls_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" buildMode="Global" isDefault="1">
+        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
       </Parameter>
-      <Parameter id="HiiriRRMWUCoK1IYUL6qfQ" name="Default Intestinal permeability (transcellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_default" buildMode="Global" isDefault="1" displayUnit="cm/min">
-        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="75" />
+      <Parameter id="wMLHMub_EkqtlV9jQ7S5yA" name="P_pls_bc_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" buildMode="Global" isDefault="1">
+        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
       </Parameter>
-      <Parameter id="ikcQ6bIVkE2RJLBTvouvYw" name="P (plasma-&gt;blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_pls_rbc" buildMode="Global" isDefault="1" displayUnit="cm/min">
-        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="75" />
+      <Parameter id="Y44LMzCQj0CkcrG9LqMpag" name="Partition coefficient (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" buildMode="Global" isDefault="1">
+        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="67" />
       </Parameter>
-      <Parameter id="4YdINXNykE-xa40oVt_O1w" name="Fraction unbound (plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionInVitro_PKSim.PARAM_fu" buildMode="Global" isDefault="1">
+      <Parameter id="xKrdQC31c0SnwfAYjdJmyg" name="Fraction unbound (plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionInVitro_PKSim.PARAM_fu" buildMode="Global" isDefault="1">
         <Info min="0" max="1" flag="62" seq="3" ref="0" bb="2" group="146" />
       </Parameter>
-      <Parameter id="gPYw2pqJ5kypqszgYpbvYQ" name="Blood/Plasma concentration ratio" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionInVitro_PKSim.PARAM_Blood2Plasma" buildMode="Global" isDefault="1">
+      <Parameter id="015bACkXFk-5G1G0uZwDGQ" name="Blood/Plasma concentration ratio" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionInVitro_PKSim.PARAM_Blood2Plasma" buildMode="Global" isDefault="1">
         <Info min="0" flag="122" seq="10" ref="0" bb="2" group="67" />
       </Parameter>
     </Children>
   </GlobalMoleculeDependentProperties>
   <TopContainers>
-    <Container id="ru23f4hjDk-aprK18rjd9g" name="Organism" mode="Logical" containerType="Organism">
+    <Container id="AUX60rXhpUaz-mnl6CP9wQ" name="Organism" mode="Logical" containerType="Organism">
       <Children>
-        <Parameter id="TyaXLeCWr0ebYuiEoQ3Lcw" name="SA proportionality factor" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="9500" displayUnit="1/cm">
+        <Parameter id="qJuST0P2BEuC77T0spODzQ" name="SA proportionality factor" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="9500" displayUnit="1/cm">
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         </Parameter>
-        <Parameter id="wAYxBwDlWkqkMWz8Zt94Jg" name="Volume (plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_VolumePlasma" isDefault="1" displayUnit="l">
-          <Info min="0" flag="60" seq="1" ref="0" bb="2" group="126" />
+        <Parameter id="2xtgadcw1UuHS3ngzzOMbA" name="Specific clearance (endosome)" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_CLSpec_endosomal_global" isDefault="1" displayUnit="1/min">
+          <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+          <Info min="0" flag="58" seq="1" ref="0" bb="32" group="25" />
         </Parameter>
-        <Parameter id="xfJCOAXRykmaulC41spBKA" name="Surface area scaling exponent" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+        <Parameter id="5wDJH9R1XE2z6hgB2VxVqA" name="Surface area scaling exponent" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
           <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
           <Info flag="54" seq="1" ref="0" bb="32" group="118" />
         </Parameter>
-        <Parameter id="6x3Amk8hAEGJfHJHRLofGw" name="Specific clearance (endosome)" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_CLSpec_endosomal_global" isDefault="1" displayUnit="1/min">
-          <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-          <Info min="0" flag="58" seq="1" ref="0" bb="32" group="25" />
+        <Parameter id="2e7wwwbg40SF5U79vSn5KA" name="Volume (plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_VolumePlasma" isDefault="1" displayUnit="l">
+          <Info min="0" flag="60" seq="1" ref="0" bb="2" group="126" />
         </Parameter>
-        <Parameter id="46_HKBCnBk2N1vMIPVoOog" name="Weight of tissue organs" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_Tissue_Organs_Weight" isDefault="1" displayUnit="kg">
+        <Parameter id="jtZH7FD-jkGinGmdSbdI6g" name="Weight" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_BW" isDefault="1" displayUnit="kg">
           <Info min="0" flag="60" seq="2" ref="0" bb="32" group="6" />
         </Parameter>
-        <Parameter id="Hwd7cUm0lUqOGnLD9eEzTQ" name="Weight" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_BW" isDefault="1" displayUnit="kg">
+        <Parameter id="OmYjyicVxE2BPVC3K7NutA" name="Weight of blood organs" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_Blood_Organs_Weight" isDefault="1" displayUnit="kg">
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         </Parameter>
-        <Parameter id="lsp0VIvuEUiHnUMIT7eZbw" name="Weight of blood organs" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_Blood_Organs_Weight" isDefault="1" displayUnit="kg">
+        <Parameter id="JNSCyrpKqECutBFeygUZNA" name="Weight of tissue organs" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_Tissue_Organs_Weight" isDefault="1" displayUnit="kg">
           <Info min="0" flag="60" seq="2" ref="0" bb="32" group="6" />
         </Parameter>
-        <Parameter id="JvWg_TadQE-AixElB9NQEg" name="Estimated gestational age" icon="Parameter" persistable="0" isFixedValue="0" dim="Age in weeks" quantityType="Parameter" negativeValuesAllowed="1" formula="GFR_Calculation.PARAM_PostMenstrualAge" isDefault="1" displayUnit="week(s)">
+        <Parameter id="TDsbMhxKtkK1BxTDzSQeGA" name="Estimated gestational age" icon="Parameter" persistable="0" isFixedValue="0" dim="Age in weeks" quantityType="Parameter" negativeValuesAllowed="1" formula="GFR_Calculation.PARAM_PostMenstrualAge" isDefault="1" displayUnit="week(s)">
           <Info min="0" flag="54" seq="4" ref="0" bb="32" group="6" />
         </Parameter>
-        <Parameter id="uAU1vEOd7UysA-mE_HUA2g" name="BMI" icon="Parameter" persistable="0" isFixedValue="0" dim="BMI" quantityType="Parameter" negativeValuesAllowed="1" formula="BMI.PARAM_BMI" isDefault="1" displayUnit="kg/m²">
-          <ValueOrigin id="51" description="Standard definition" />
+        <Parameter id="2kXfcHS-R0Wbhuj_SOR5Nw" name="BMI" icon="Parameter" persistable="0" isFixedValue="0" dim="BMI" quantityType="Parameter" negativeValuesAllowed="1" formula="BMI.PARAM_BMI" isDefault="1" displayUnit="kg/m²">
+          <ValueOrigin id="51" source="Other" description="Standard definition" />
           <Info min="0.04" max="1.5" flag="60" seq="5" ref="0" bb="32" group="6" />
         </Parameter>
-        <Parameter id="LcznH4YTEEiNwrpxmcBjtw" name="BSA" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Body surface area - Mosteller.PARAM_BSA" isDefault="1" displayUnit="m²">
+        <Parameter id="JXj7P782G0KOfw5XFsAPkg" name="BSA" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Body surface area - Mosteller.PARAM_BSA" isDefault="1" displayUnit="m²">
           <Info flag="58" seq="6" ref="0" bb="32" group="6" />
         </Parameter>
-        <Parameter id="URMB_8Scn0u9-szk_Q3l_A" name="Protein ratio (interstial/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.37">
+        <Parameter id="WsnRGAA_ikClECjGxMVPzA" name="pH (blood cells)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.22">
+          <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
+          <Info min="0" max="14" flag="122" seq="1" ref="0" bb="32" group="82" />
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                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                     </Parameter>
-                    <Parameter id="-8BcC-NehECKWSfdc80dEQ" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
+                    <Parameter id="eX8y6R_sTUmU3bVl4wTcNg" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
                       <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                     </Parameter>
                   </Children>
                 </Container>
               </Children>
             </Container>
-            <Container id="H3YIKhsT9kW_XjjpUkxqNg" name="BloodCells" mode="Physical" containerType="Compartment">
+            <Container id="bHtbzf2QTkS9BPP8ck7mNg" name="BloodCells" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="BloodOrgan" />
                 <Tag value="VenousBlood" />
               </Tags>
               <Children>
-                <Parameter id="V-RQsSNGfU-7RfJjz6lb5g" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                <Parameter id="VMM7O20fek-zAYN4LXY_UA" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
                   <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                 </Parameter>
-                <Parameter id="erLci12ifk2mGaIw_7OrOw" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_bc_blood_organ_4comp" isDefault="1" displayUnit="l">
+                <Parameter id="yEkZR3g4WE21mt9dlWaKDw" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_bc_blood_organ_4comp" isDefault="1" displayUnit="l">
                   <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                   <Info min="0" flag="62" seq="3" ref="0" bb="2" group="121" />
                 </Parameter>
-                <Container id="KiSCGMjZzkW74-7tCYvwjw" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="owIXRe1PZkyspaqQWHixUQ" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                   <Children>
-                    <Parameter id="7iMYBOzch0KjG_HsX-uX1Q" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                    <Parameter id="YYp6nFEXnEm5i8-cTQfsDQ" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                     </Parameter>
-                    <Parameter id="OIoYCkB2O0KpjQwZLm7-Tw" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" isDefault="1">
+                    <Parameter id="24AcKvuWmUGWO4xqafqi6g" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                     </Parameter>
-                    <Parameter id="zMj6IOtfSkGTsO4paW0Lqw" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
+                    <Parameter id="hW8s0exs-0q7xT8jhQ4xLA" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
                       <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                     </Parameter>
                   </Children>
@@ -363,109 +366,110 @@
             </Container>
           </Children>
         </Container>
-        <Container id="Z_kyXxqhu0yVswLRiX32qw" name="ArterialBlood" mode="Logical" containerType="Organ">
+        <Container id="eOyXWJT7VkOchwHtKGZ1Xw" name="ArterialBlood" mode="Logical" containerType="Organ">
           <Tags>
             <Tag value="BloodOrgan" />
           </Tags>
           <Children>
-            <Parameter id="c8cFj372h0mXH2KVxzT90g" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
+            <Parameter id="4LcXtiU_tUOlvEW6AQkGkQ" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
               <Tags>
                 <Tag value="BloodOrgan" />
               </Tags>
               <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
             </Parameter>
-            <Parameter id="hRFo8IiMAkqUBwI76Q_N7A" name="Density (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
+            <Parameter id="52O8SBINzkyWeR3_Nr2Cag" name="Density (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
               <Tags>
                 <Tag value="BloodOrgan" />
               </Tags>
               <Info min="0" flag="38" seq="1" ref="0" bb="32" group="21" />
             </Parameter>
-            <Parameter id="P3SsNmzu_UGl2cXOD201oA" name="Peripheral blood flow fraction" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0">
+            <Parameter id="NAx6SSV-BkmnqF7PY7n-0w" name="Peripheral blood flow fraction" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0">
               <Tags>
                 <Tag value="BloodOrgan" />
               </Tags>
               <ValueOrigin id="46" source="Publication" description="Thiel C, Schneckener S, Krauss M, Ghallab A, Hofmann U, et al. A systematic evaluation of the use of physiologically based pharmacokinetic modeling for cross-species extrapolation. J Pharm Sci. 2015 Jan;104(1):191-206 https://doi.org/10.1002/jps.24214" />
               <Info min="0" max="1" flag="122" seq="1" ref="0" bb="32" group="74" />
             </Parameter>
-            <Parameter id="pTdE6b92dEm_GxnelrProw" name="Allometric scale factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.75">
+            <Parameter id="II8worH3HUS-cIx0go5eRg" name="Allometric scale factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.75">
               <Tags>
                 <Tag value="BloodOrgan" />
               </Tags>
               <Info min="0.75" max="0.75" flag="52" seq="1" ref="0" bb="32" group="2" />
             </Parameter>
-            <Parameter id="jROouJbe70i4WM0szGqKHQ" name="Fraction vascular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+            <Parameter id="t_12Xn_SuEWWJdnEkZSPrQ" name="Fraction vascular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
               <Tags>
                 <Tag value="BloodOrgan" />
               </Tags>
               <Info min="0" max="1" flag="62" seq="12" ref="0" bb="32" group="64" />
             </Parameter>
-            <DistributedParameter id="IiNhVzyA7Ei_fOSbYN0EHA" name="Volume" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="uDu0fHA4o02ddM2lg7WlYw" mode="Logical" isDefault="1" displayUnit="l">
+            <DistributedParameter id="Y_3Q04agAUGnAztsPkRxLw" name="Volume" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="cjWO9IXVoUObVBaaZ6fBUg" mode="Logical" isDefault="1" displayUnit="l">
               <Children>
-                <Parameter id="oykNnFwicUmVwuS4zhZ8dg" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.500256823513264" displayUnit="l">
+                <Parameter id="5VNltPMgkkiI36jGBJKXCg" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.50020155879836" displayUnit="l">
                   <Info min="0" flag="18" seq="1" ref="0" bb="32" group="65" />
                 </Parameter>
-                <Parameter id="ah7azhuQSkSjLuH2KHR4Nw" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.337622553" displayUnit="l">
+                <Parameter id="NrJ-8CVr30Sb9mJZPoFRXw" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.419080314" displayUnit="l">
                   <Info min="0" flag="34" seq="1" ref="0" bb="32" group="65" />
                 </Parameter>
-                <Parameter id="4w9JZVAcgECxYML-rriRew" name="Deviation" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.016881128" displayUnit="l">
+                <Parameter id="mSRFnEoCV06mynSVGcbYLg" name="Deviation" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.020954016" displayUnit="l">
                   <Info min="0" flag="18" seq="1" ref="0" bb="32" group="65" />
                 </Parameter>
               </Children>
               <Tags>
                 <Tag value="BloodOrgan" />
               </Tags>
+              <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
               <Info min="0" flag="106" seq="1" ref="0" bb="32" group="65" />
             </DistributedParameter>
-            <Container id="bS-sGM903k-X6Tuo2p8Ujw" name="Plasma" mode="Physical" containerType="Compartment">
+            <Container id="gQ0ACyX0OkaArtZvQ5x4bA" name="Plasma" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="ArterialBlood" />
                 <Tag value="BloodOrgan" />
               </Tags>
               <Children>
-                <Parameter id="bqGttUFyB0K7Kj_Ehqtwbw" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                <Parameter id="v665F8AdA0OjV-7izAlm9A" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
                   <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                 </Parameter>
-                <Parameter id="F4Q1hTBVMkuAjQaKDhooqg" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_pls_BloodOrgan_4Comp" isDefault="1" displayUnit="l">
+                <Parameter id="gb0Uru8I9ECMiRgep4uinQ" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_pls_BloodOrgan_4Comp" isDefault="1" displayUnit="l">
                   <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                   <Info min="0" flag="62" seq="4" ref="0" bb="2" group="126" />
                 </Parameter>
-                <Container id="q1QRS4zD_EGVVbqHTOWjeQ" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="r57X4I6Ve0mU25Cqb_XIkg" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                   <Children>
-                    <Parameter id="bCKGrdYs5Eytm85ve9Uy0A" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
-                      <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                    <Parameter id="4-uHLFNvHUux8UWfKf-P0Q" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                     </Parameter>
-                    <Parameter id="cHmsM06iq0CId4qa25QZ_Q" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" isDefault="1">
+                    <Parameter id="Hn5NDfOxdE2p0PXNi-FHbA" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                     </Parameter>
-                    <Parameter id="RLOVtwKbK0qnV2JEu2pNDw" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
-                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                    <Parameter id="8tIF7uqnYEShXq3paFH-KA" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
+                      <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                     </Parameter>
                   </Children>
                 </Container>
               </Children>
             </Container>
-            <Container id="qoa86WWLDUurU06K0cENRA" name="BloodCells" mode="Physical" containerType="Compartment">
+            <Container id="zmZFE8nEqEm0ej9vgvDMqA" name="BloodCells" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="ArterialBlood" />
                 <Tag value="BloodOrgan" />
               </Tags>
               <Children>
-                <Parameter id="MB27FOXVJE2h2sHUhwD4tg" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                <Parameter id="HH4x9dCMfkK2DoOgds4svw" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
                   <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                 </Parameter>
-                <Parameter id="vmToXNWxd06ncfXP3wgf2w" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_bc_blood_organ_4comp" isDefault="1" displayUnit="l">
+                <Parameter id="WX9ijrW48EGziYAEyD7czw" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_bc_blood_organ_4comp" isDefault="1" displayUnit="l">
                   <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                   <Info min="0" flag="62" seq="4" ref="0" bb="2" group="121" />
                 </Parameter>
-                <Container id="7TEyemIxNUe4ulRp3gq3VQ" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="Y7iMLjJI4EaZ86GnN-Fbbw" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                   <Children>
-                    <Parameter id="Mh7FElNy7kC-ZYPNKpIC7A" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                    <Parameter id="x_xG8yQtCEGABLYtSDwHJA" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                     </Parameter>
-                    <Parameter id="2dzf73GiqEeSdhg4Ds9-og" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" isDefault="1">
+                    <Parameter id="vYG6p3vKak-FbnsAZAYHqQ" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                     </Parameter>
-                    <Parameter id="xGEX66u07E6ig9chddHUvw" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
+                    <Parameter id="VzyU8h3MEEOw2ll9BtYmZQ" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
                       <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                     </Parameter>
                   </Children>
@@ -474,438 +478,411 @@
             </Container>
           </Children>
         </Container>
-        <Container id="016IibKr-0yy9e0KyKrkrQ" name="Gallbladder" mode="Physical" containerType="Organ">
-          <Tags>
-            <Tag value="Liver" />
-          </Tags>
-          <Children>
-            <Parameter id="yuYGmgmCxE-LCheo5S8Z9Q" name="Time to complete gallbladder refilling" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_GallbladderRefillTime" isDefault="1" displayUnit="min">
-              <Info min="0" flag="122" seq="3" ref="0" bb="2" group="128" />
-            </Parameter>
-            <Parameter id="O36w-U8yEEmqrJ5RtRnfKw" name="Gallbladder emptying active" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0">
-              <Info min="0" max="1" flag="52" seq="4" ref="0" bb="2" group="128" />
-            </Parameter>
-            <Parameter id="qjVW7D7XZk2c0VvRi8YaTg" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="l">
-              <Info min="0" flag="38" seq="666" ref="0" bb="2" group="65" />
-            </Parameter>
-            <Parameter id="KgD2worJAUCiCvdaGDTFgg" name="Gallbladder ejection half-time" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="19.7" displayUnit="min">
-              <Tags>
-                <Tag value="Liver" />
-              </Tags>
-              <Info min="0" flag="122" seq="1" ref="0" bb="32" group="128" />
-            </Parameter>
-            <Parameter id="T-xduoehj0-Fm_kqylDYng" name="Gallbladder ejection fraction" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.65">
-              <Tags>
-                <Tag value="Liver" />
-              </Tags>
-              <Info min="0" max="1" flag="122" seq="2" ref="0" bb="32" group="128" />
-            </Parameter>
-            <Container id="ZjvKkkabDE-8ETOQITxmYA" name="MoleculeProperties" mode="Logical" containerType="Molecule" />
-          </Children>
-        </Container>
-        <Container id="seG5ABcBLkaSYgzblmYmrw" name="Bone" mode="Logical" containerType="Organ">
+        <Container id="O5mx1DfGakGs1eyerXHh-A" name="Bone" mode="Logical" containerType="Organ">
           <Tags>
             <Tag value="TissueOrgan" />
           </Tags>
           <Children>
-            <Parameter id="RSLLeebVb0aNyjksHDvOKg" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
+            <Parameter id="Tvy5l1YkBEu8QHDOHQRoVw" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
             </Parameter>
-            <Parameter id="jxznm7YPA06UbXc0UZbZ_w" name="Blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_from_Qspec" isDefault="1" displayUnit="l/min">
+            <Parameter id="9F3RZimeREG39pPDhInIGw" name="Blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_from_Qspec" isDefault="1" displayUnit="l/min">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
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+            <Parameter id="LF5stt5z9ke9-5Re4LlsvQ" name="Fluid recirculation flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate" isDefault="1" displayUnit="l/min">
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+            <Parameter id="mQioWrCvYkmYOCrKgL3luA" name="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Lymph_flow_rate" isDefault="1" displayUnit="l/min">
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+            <Parameter id="foc5PhoY_0WturXBTERKwg" name="Volume (endothelium)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="VascularEndoVolume.VOLUME_VascularEndo_bon" isDefault="1" displayUnit="l">
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+            <Parameter id="8RRdNnNtZUulrtiuIwGXkw" name="Fraction intracellular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_f_cell" isDefault="1">
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+            <Parameter id="FznOZF8nAUe_aXWIRRsRgQ" name="Density (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
               <Tags>
                 <Tag value="TissueOrgan" />
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-              <Info min="0" flag="54" seq="1" ref="0" bb="32" group="65" />
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             </Parameter>
-            <Parameter id="QkGKWA_mvEaUS8PcW_fXsA" name="Density (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
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                 <Tag value="TissueOrgan" />
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+            <Parameter id="9W7p5z6Nb0uhoawFmo3U-Q" name="Organ volume mouse" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.00158" displayUnit="l">
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+            <Parameter id="vxPjSlqQBUKiUVPINrTsTA" name="Radius (large pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.5E-07" displayUnit="µm">
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+            <Parameter id="_5gdyn3NjEe8tZ38Hj9dBw" name="Radius (small pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="4.5E-08" displayUnit="µm">
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-              <Info min="0" max="1" flag="122" seq="16" ref="0" bb="32" group="85" />
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-              <Info min="0" max="1" flag="122" seq="17" ref="0" bb="32" group="85" />
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             </Parameter>
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+              <Info min="0" max="1" flag="122" seq="17" ref="0" bb="32" group="85" />
+            </Parameter>
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                   <Info min="0" max="14" flag="122" seq="17" ref="0" bb="32" group="84" />
                 </Parameter>
-                <Container id="Li_ri1io30GvsFoFDYBNow" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="706OHUA1DUSCwupIMEN6Mw" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                   <Children>
-                    <Parameter id="9kLs91IVKUmHEN3y7Vjf8A" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                    <Parameter id="l0Uj6Ak8F0KTAXyQV3qpFA" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                     </Parameter>
-                    <Parameter id="4CwGfr2AwkS-LcvK413iOw" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_bon" isDefault="1">
+                    <Parameter id="s8VDDMHQh0GdZfIaF3mBKg" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_bon" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                     </Parameter>
-                    <Parameter id="kWGNSC2htECeQs7c-HIs2Q" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
+                    <Parameter id="FGLgwulyckGOn-81sIpUaw" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
                       <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                     </Parameter>
                   </Children>
                 </Container>
               </Children>
             </Container>
-            <Container id="OZwyijncuUCfTAtyFAv4pQ" name="Intracellular" mode="Physical" containerType="Compartment">
+            <Container id="oqcD8Ok_Rkqcn4uurotLfg" name="Intracellular" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="Bone" />
               </Tags>
               <Children>
-                <Parameter id="4i14MgPDgU-m4Q6-pGeijQ" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" isDefault="1" displayUnit="l">
+                <Parameter id="WUdJSW8Gn021kRWE7xInAw" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" isDefault="1" displayUnit="l">
                   <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                 </Parameter>
-                <Parameter id="Fq3dIU4rU0q_6n2byA9rhg" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" isDefault="1" displayUnit="l">
+                <Parameter id="RDFg9nJwnEWtOVFrRXzZQg" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" isDefault="1" displayUnit="l">
                   <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                   <Info min="0" flag="62" seq="5" ref="0" bb="2" group="125" />
                 </Parameter>
-                <Parameter id="bPjX8ZuUWkeqeBqCU_AohQ" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7">
+                <Parameter id="SpjqRhd5YUa8B57zT2YdFQ" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7">
                   <Tags>
                     <Tag value="Bone" />
                   </Tags>
                   <ValueOrigin id="34" source="Publication" description="Toxicol In Vitro. 2008 Mar;22(2):457-67 https://doi.org/10.1016/j.tiv.2007.09.010" />
                   <Info min="0" max="14" flag="122" seq="17" ref="0" bb="32" group="83" />
                 </Parameter>
-                <Container id="n9gtOvY1TkyuuDifvRkFXQ" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="UmFUaCF8OUuUvL_lRgHUkQ" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                   <Children>
-                    <Parameter id="Bqns_x1y4kWVN7td_QdNuA" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                    <Parameter id="l3uJFXgvoU-zaD05Fx78nQ" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                     </Parameter>
-                    <Parameter id="JyfMJCiBEUC8FzwbR3bIIQ" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_bon" isDefault="1">
+                    <Parameter id="4_JswxHiPU2zpAvrbDLdtg" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_bon" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                     </Parameter>
-                    <Parameter id="GOqTOqgYnUansMqxvQNhUQ" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
+                    <Parameter id="9wRGxOIK1Eqma07aFuQeqA" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
                       <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                     </Parameter>
                   </Children>
@@ -914,402 +891,433 @@
             </Container>
           </Children>
         </Container>
-        <Container id="Pff62b_fHEyhjPVfujl01w" name="Brain" mode="Logical" containerType="Organ">
+        <Container id="wmf2zTyOt0m6vj1K0wTYqQ" name="Gallbladder" mode="Physical" containerType="Organ">
+          <Tags>
+            <Tag value="Liver" />
+          </Tags>
+          <Children>
+            <Parameter id="jNp-ipUL30mXkRUF-JrI7g" name="Time to complete gallbladder refilling" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_GallbladderRefillTime" isDefault="1" displayUnit="min">
+              <Info min="0" flag="122" seq="3" ref="0" bb="2" group="128" />
+            </Parameter>
+            <Parameter id="2b-2yRIt2UKlvy62RNUDJw" name="Gallbladder emptying active" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0">
+              <Info min="0" max="1" flag="52" seq="4" ref="0" bb="2" group="128" />
+            </Parameter>
+            <Parameter id="4NHMtVSNqUWVey6YhAukRg" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="l">
+              <Info min="0" flag="38" seq="666" ref="0" bb="2" group="65" />
+            </Parameter>
+            <Parameter id="jGgKuemxg0iBUHHrHeLwhg" name="Gallbladder ejection half-time" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="19.7" displayUnit="min">
+              <Tags>
+                <Tag value="Liver" />
+              </Tags>
+              <Info min="0" flag="122" seq="1" ref="0" bb="32" group="128" />
+            </Parameter>
+            <Parameter id="jXhbzm2JK0mp_7wSzpnurw" name="Gallbladder ejection fraction" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.65">
+              <Tags>
+                <Tag value="Liver" />
+              </Tags>
+              <Info min="0" max="1" flag="122" seq="2" ref="0" bb="32" group="128" />
+            </Parameter>
+            <Container id="lsZyX0ttIEyuKX2cAjv8BQ" name="MoleculeProperties" mode="Logical" containerType="Molecule" />
+          </Children>
+        </Container>
+        <Container id="IsoD58V0Gk-I4QtgeJ935Q" name="Brain" mode="Logical" containerType="Organ">
           <Tags>
             <Tag value="TissueOrgan" />
           </Tags>
           <Children>
-            <Parameter id="Q1qn8mptXE6i4cq15O-Klg" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
+            <Parameter id="c7FduDI2LUmORyv_vxqxsw" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
             </Parameter>
-            <Parameter id="4OClEazNiEacNBHz6qgeVw" name="Volume (endothelium)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="VascularEndoVolume.VOLUME_VascularEndo_brn" isDefault="1" displayUnit="l">
+            <Parameter id="Lc6J9f1ns0S5BndBS0P4Gw" name="Fluid recirculation flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate" isDefault="1" displayUnit="l/min">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
-              <Info min="0" flag="62" seq="6" ref="0" bb="32" group="127" />
+              <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+              <Info min="0" flag="122" seq="6" ref="0" bb="32" group="27" />
             </Parameter>
-            <Parameter id="_RxbqCW7akuhJ6gIEvkzlg" name="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Lymph_flow_rate" isDefault="1" displayUnit="l/min">
+            <Parameter id="KvoUHoxG3USjHgPBg8rm-w" name="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Lymph_flow_rate" isDefault="1" displayUnit="l/min">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
               <Info min="0" flag="122" seq="6" ref="0" bb="32" group="58" />
             </Parameter>
-            <Parameter id="hpCsCQmybEW3yxsS5vP7Dw" name="Fluid recirculation flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate" isDefault="1" displayUnit="l/min">
+            <Parameter id="PSfWzJZDB0SjNkx1iP5pqA" name="Volume (endothelium)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="VascularEndoVolume.VOLUME_VascularEndo_brn" isDefault="1" displayUnit="l">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
-              <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-              <Info min="0" flag="122" seq="6" ref="0" bb="32" group="27" />
+              <Info min="0" flag="62" seq="6" ref="0" bb="32" group="127" />
             </Parameter>
-            <Parameter id="lDDkgGBBX0WBe_9eVbsnBw" name="Fraction intracellular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_f_cell" isDefault="1">
+            <Parameter id="2gW31SMOAkuBECG3WVXzhA" name="Fraction intracellular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_f_cell" isDefault="1">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" max="1" flag="62" seq="19" ref="0" bb="32" group="64" />
             </Parameter>
-            <Parameter id="_1jaw4JPcUeQWiDhiZzOzQ" name="Blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_from_Qspec" isDefault="1" displayUnit="l/min">
+            <Parameter id="Z_JK72sLvU6i9d3cul2Y0g" name="Blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_from_Qspec" isDefault="1" displayUnit="l/min">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
-              <ValueOrigin id="48" description="TODO: Absolute from specific calculation" />
+              <ValueOrigin id="48" source="Other" description="Absolute value = specific value (i.e. value normalized to the volume of the organ) multiplied by the organ volume" />
               <Info min="0" flag="62" seq="22" ref="0" bb="32" group="5" />
             </Parameter>
-            <Parameter id="tL4K2lExvUyDyquQTL9U0Q" name="Density (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
+            <Parameter id="iELY3sf5ykGu00tKSKUryA" name="Density (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" flag="38" seq="1" ref="0" bb="32" group="21" />
             </Parameter>
-            <Parameter id="_ArEKPvmkU6lmMPdu1sKYg" name="Fluid recirculation flow proportionality factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.404">
+            <Parameter id="dCT0IVa-AkezD5yWWxNWpw" name="Fluid recirculation flow proportionality factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.404">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" flag="54" seq="1" ref="0" bb="32" group="27" />
             </Parameter>
-            <Parameter id="fSQELYE3t0mI0RaiK54bJQ" name="Lymph flow proportionality factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.27E-05">
+            <Parameter id="egQ7BPRJGkepWnfUPd18Sg" name="Lymph flow proportionality factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.27E-05">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" flag="54" seq="1" ref="0" bb="32" group="58" />
             </Parameter>
-            <Parameter id="7lDOMnj27EqLO5m2N3tk5Q" name="Organ volume mouse" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.00017" displayUnit="l">
+            <Parameter id="uqBSYBs5a0Wk6j40i9LNIQ" name="Organ volume mouse" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.00017" displayUnit="l">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" flag="54" seq="1" ref="0" bb="32" group="65" />
             </Parameter>
-            <Parameter id="tBDN6qQBWkGnfTCYGNiSCA" name="Allometric scale factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0">
+            <Parameter id="riolueuyQE6EQRnFdchJ7g" name="Allometric scale factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" max="0" flag="54" seq="1" ref="0" bb="32" group="2" />
             </Parameter>
-            <Parameter id="Ha2qRWYWuUObbIp5gU7h8Q" name="Fraction of blood for sampling" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+            <Parameter id="7ul9jovvA0asb-A1-aNimQ" name="Fraction of blood for sampling" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" max="1" flag="54" seq="1" ref="0" bb="32" group="94" />
             </Parameter>
-            <Parameter id="ewZIZYnly0iUW1k9PZyO6A" name="Radius (small pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="4.5E-08" displayUnit="µm">
+            <Parameter id="vLrCqYU87Eedh4bK2W0aBg" name="Flow fraction via large pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.05">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-              <Info min="0" flag="122" seq="6" ref="0" bb="32" group="99" />
+              <Info min="0" max="1" flag="122" seq="6" ref="0" bb="32" group="114" />
             </Parameter>
-            <Parameter id="AxP6Kur4MUKPSxnpXF3DTA" name="Hydraulic conductivity" icon="Parameter" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="5E-14" displayUnit="ml/min/N">
+            <Parameter id="z53irlKn50m_i7YgU1E4EA" name="Hydraulic conductivity" icon="Parameter" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="5E-14" displayUnit="ml/min/N">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
               <Info min="0" flag="122" seq="6" ref="0" bb="32" group="115" />
             </Parameter>
-            <Parameter id="qBDqyrSooEuDiI_dukU3Ig" name="Flow fraction via large pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.05">
+            <Parameter id="cbJ4lZM-2U6l_kLKjkHk-g" name="Radius (large pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.5E-07" displayUnit="µm">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-              <Info min="0" max="1" flag="122" seq="6" ref="0" bb="32" group="114" />
+              <Info min="0" flag="122" seq="6" ref="0" bb="32" group="55" />
             </Parameter>
-            <Parameter id="9KfV4tt8s0-454baxIQvjQ" name="Radius (large pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.5E-07" displayUnit="µm">
+            <Parameter id="e2rq3kTBk0-wXkEWBUFtVw" name="Radius (small pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="4.5E-08" displayUnit="µm">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-              <Info min="0" flag="122" seq="6" ref="0" bb="32" group="55" />
+              <Info min="0" flag="122" seq="6" ref="0" bb="32" group="99" />
             </Parameter>
-            <Parameter id="6t8jDclRhU-EQO_2hz5DvA" name="Vf (neutral lipid)-PT" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.051">
+            <Parameter id="EwmBMlkF9USSuL8DCqmg3Q" name="Fraction vascular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.039">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
-              <Info min="0" max="1" flag="122" seq="18" ref="0" bb="32" group="86" />
+              <ValueOrigin id="40" source="Publication" description="Edginton, A.N., Schmitt, W. &amp; Willmann, S. Clin Pharmacokinet (2006) 45: 1013. https://doi.org/10.2165/00003088-200645100-00005" />
+              <Info min="0" max="1" flag="62" seq="18" ref="0" bb="32" group="64" />
             </Parameter>
-            <Parameter id="S7T8y4pyEUCSVOripx0jIw" name="Vf (lipid)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.11">
+            <Parameter id="zwfITQf1lEig-8r5mehKNA" name="Vf (lipid)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.11">
               <Tags>
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                   <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                 </Parameter>
-                <Parameter id="Hal9pJixikSMYi1SF1WepQ" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" isDefault="1" displayUnit="l">
+                <Parameter id="ps7muVcOUU-yxGK-1Zyhtw" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" isDefault="1" displayUnit="l">
                   <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                   <Info min="0" flag="62" seq="6" ref="0" bb="2" group="126" />
                 </Parameter>
-                <Container id="OdwnoJZyikSiaRxoZZaWcw" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="RTYUEKKNLUS4dCYmeyggQg" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                   <Children>
-                    <Parameter id="vmTq8FnPVkKP-8b4p3MyGA" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
-                      <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
-                    </Parameter>
-                    <Parameter id="PegRIJUO806iSv6lCCU5lA" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                    <Parameter id="-I7F3yLxT0KcFnp6i6frGA" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                     </Parameter>
-                    <Parameter id="-zfzh3nLhEiida_thtrdqw" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" isDefault="1">
+                    <Parameter id="98dc9BnyFE2KlS479maxqg" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                     </Parameter>
+                    <Parameter id="8VoLJhdCl0KVwsXs9ncn2w" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
+                      <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                    </Parameter>
                   </Children>
                 </Container>
               </Children>
             </Container>
-            <Container id="FcxxDdjBhUKABUVCEaoBQw" name="BloodCells" mode="Physical" containerType="Compartment">
+            <Container id="_kM6rV4F-UGU7WOAUGLsGw" name="BloodCells" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="Brain" />
               </Tags>
               <Children>
-                <Parameter id="CKM-g-nKwkqD9at2tcQfrg" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                <Parameter id="wnnfZgWqh0GfcUtK18tkXQ" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
                   <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                 </Parameter>
-                <Parameter id="2WH8y1KYV0GFrW9agPyNyQ" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" isDefault="1" displayUnit="l">
+                <Parameter id="qRChHTLMDUC3DJhOvzRgow" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" isDefault="1" displayUnit="l">
                   <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                   <Info min="0" flag="62" seq="6" ref="0" bb="2" group="121" />
                 </Parameter>
-                <Container id="h7-quRpZ1U-UxfhPe0yqfg" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="RRQzXHOcLE6YBTHflBQidw" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                   <Children>
-                    <Parameter id="X1tj9dl8hU-G6fAAgdlWdw" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                    <Parameter id="zxIXiMJ9BEiTXvAMF1bkFQ" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                     </Parameter>
-                    <Parameter id="-ycIBl-4rECNKmb1549BRg" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
-                      <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
-                    </Parameter>
-                    <Parameter id="ReBEJ6g-Z0K1s-n2h2EiCw" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" isDefault="1">
+                    <Parameter id="ZHhEsnrRrUyu-9pn2XFkdQ" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                     </Parameter>
+                    <Parameter id="ncf0c_AqjE2wwwFrHDiRtA" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
+                      <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                    </Parameter>
                   </Children>
                 </Container>
               </Children>
             </Container>
-            <Container id="E3frYmlADUCgUSLuYPaIig" name="Interstitial" mode="Physical" containerType="Compartment">
+            <Container id="ADDQZ02oqE2UpCNzxzZbDA" name="Interstitial" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="Brain" />
               </Tags>
               <Children>
-                <Parameter id="Yf4gs_xfIUGtYxCkjWer6w" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                <Parameter id="Gbqw79T-jk2_uoHDUlCmcA" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
                   <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                 </Parameter>
-                <Parameter id="IEON090b-kuVUto8KmykkA" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" isDefault="1" displayUnit="l">
+                <Parameter id="THsbSQ7eJki4DAOnQd9rwQ" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" isDefault="1" displayUnit="l">
                   <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                   <Info min="0" flag="62" seq="6" ref="0" bb="2" group="124" />
                 </Parameter>
-                <Parameter id="D9NtWSQvVkKi7qCgcq5g1w" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_pH_INT" isDefault="1">
+                <Parameter id="mkCPBMmoMU2q01zWDwQH5g" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_pH_INT" isDefault="1">
                   <Tags>
                     <Tag value="Brain" />
                   </Tags>
                   <Info min="0" max="14" flag="122" seq="20" ref="0" bb="32" group="84" />
                 </Parameter>
-                <Container id="aRw-LNZTsUW21Wx4D0zeuw" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="swssYh-iYU-OF_SalpJkcg" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                   <Children>
-                    <Parameter id="DJMMYohQXk2HazcIH8ICzQ" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_brn" isDefault="1">
-                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
-                    </Parameter>
-                    <Parameter id="sgFQFno8n0GNkVspHmC8AQ" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                    <Parameter id="xc4Q40IsuEGU9QtS4R-Rvw" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                     </Parameter>
-                    <Parameter id="HNBeFrPTlkG9w4a7NPWe5Q" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
+                    <Parameter id="Y6qM62mUCEavVqSaXg8-Sw" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_brn" isDefault="1">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                    </Parameter>
+                    <Parameter id="WLE1eK_vbEuN56aGBAoq3A" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
                       <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                     </Parameter>
                   </Children>
                 </Container>
               </Children>
             </Container>
-            <Container id="PRoBTwV1tkOTdFsrXpIbvQ" name="Intracellular" mode="Physical" containerType="Compartment">
+            <Container id="W9Tmg9hHNkOrO3OgeRFoHg" name="Intracellular" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="Brain" />
               </Tags>
               <Children>
-                <Parameter id="4BDocwF7rEOyKEwOTF301A" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" isDefault="1" displayUnit="l">
+                <Parameter id="DNrpqHPw-U-lGes-ZLrUig" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" isDefault="1" displayUnit="l">
                   <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                 </Parameter>
-                <Parameter id="dJMATbJKjUSo1-Y4UlUxgg" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" isDefault="1" displayUnit="l">
+                <Parameter id="cuLLv9BCm0GhRougFF6E4A" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" isDefault="1" displayUnit="l">
                   <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                   <Info min="0" flag="62" seq="6" ref="0" bb="2" group="125" />
                 </Parameter>
-                <Parameter id="ez563YSeUkmqS3Z982yW9Q" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.1">
+                <Parameter id="TWhDFtWUzUCTw8v49dzNRQ" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.1">
                   <Tags>
                     <Tag value="Brain" />
                   </Tags>
                   <ValueOrigin id="34" source="Publication" description="Toxicol In Vitro. 2008 Mar;22(2):457-67 https://doi.org/10.1016/j.tiv.2007.09.010" />
                   <Info min="0" max="14" flag="122" seq="20" ref="0" bb="32" group="83" />
                 </Parameter>
-                <Container id="yPAmOAdbYUufMYLmS8LK1A" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="GLDXCrE8q0eVna88VV7USg" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                   <Children>
-                    <Parameter id="iDnRFZGr1U2w4Ua4Vi28QQ" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                    <Parameter id="UljcRswJOk2q4oMKgcQVYA" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                     </Parameter>
-                    <Parameter id="8nFlX9MnZkyoCMwDEty4tw" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_brn" isDefault="1">
+                    <Parameter id="J8jzk2vUFkKL9YdPsuq4Ig" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_brn" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                     </Parameter>
-                    <Parameter id="_O9A3Jg3fEu6eIcdS9Nl8w" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
+                    <Parameter id="yRdwUZFT7EOQ6JYrR-i-PA" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
                       <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                     </Parameter>
                   </Children>
@@ -1318,227 +1326,228 @@
             </Container>
           </Children>
         </Container>
-        <Container id="guH6q5n2-0uXJQEXa7TCdA" name="Fat" mode="Logical" containerType="Organ">
+        <Container id="Q1EOdO5TmE-9gYMtHz-EXQ" name="Fat" mode="Logical" containerType="Organ">
           <Tags>
             <Tag value="TissueOrgan" />
           </Tags>
           <Children>
-            <Parameter id="1oeOIASQnUie2tYcNYgs1Q" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
+            <Parameter id="S2iZkbuf4UuTTgMeRNzmXw" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
             </Parameter>
-            <Parameter id="e5K2vNW2xUmqXoBnR6rkYA" name="Volume (endothelium)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="VascularEndoVolume.VOLUME_VascularEndo_fat" isDefault="1" displayUnit="l">
+            <Parameter id="T2TIk_dX90CJscTg58bxjw" name="Fluid recirculation flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate" isDefault="1" displayUnit="l/min">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
-              <Info min="0" flag="62" seq="7" ref="0" bb="32" group="127" />
+              <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+              <Info min="0" flag="122" seq="7" ref="0" bb="32" group="27" />
             </Parameter>
-            <Parameter id="IJhieNEl2kKKs9bkjtO9zQ" name="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Lymph_flow_rate" isDefault="1" displayUnit="l/min">
+            <Parameter id="xnFm55v9jEK4loHc7wYsFw" name="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Lymph_flow_rate" isDefault="1" displayUnit="l/min">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
               <Info min="0" flag="122" seq="7" ref="0" bb="32" group="58" />
             </Parameter>
-            <Parameter id="ov-HrwkzCUaL5dI5JIHZ4w" name="Fluid recirculation flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate" isDefault="1" displayUnit="l/min">
+            <Parameter id="ynQovXYIykegX18wCJJKDQ" name="Volume (endothelium)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="VascularEndoVolume.VOLUME_VascularEndo_fat" isDefault="1" displayUnit="l">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
-              <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-              <Info min="0" flag="122" seq="7" ref="0" bb="32" group="27" />
+              <Info min="0" flag="62" seq="7" ref="0" bb="32" group="127" />
             </Parameter>
-            <Parameter id="E1LF2m8or0GKRQ-2_MOB3g" name="Fraction intracellular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_f_cell" isDefault="1">
+            <Parameter id="OCfUUL1pz0mnALkR8ZWF0g" name="Fraction intracellular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_f_cell" isDefault="1">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" max="1" flag="62" seq="22" ref="0" bb="32" group="64" />
             </Parameter>
-            <Parameter id="yBdKSAr4bESc73UUt4AyHA" name="Blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_from_Qspec" isDefault="1" displayUnit="l/min">
+            <Parameter id="5Tw4V-3D6UuMjkiowYgEqw" name="Blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_from_Qspec" isDefault="1" displayUnit="l/min">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
-              <ValueOrigin id="48" description="TODO: Absolute from specific calculation" />
+              <ValueOrigin id="48" source="Other" description="Absolute value = specific value (i.e. value normalized to the volume of the organ) multiplied by the organ volume" />
               <Info min="0" flag="62" seq="42" ref="0" bb="32" group="5" />
             </Parameter>
-            <Parameter id="lzhId7D4Bk26LbUKpeO0HQ" name="Organ volume mouse" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.001" displayUnit="l">
+            <Parameter id="FhLuur8adU2zWw_CQrTVpA" name="Density (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
-              <Info min="0" flag="54" seq="1" ref="0" bb="32" group="65" />
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-                <Parameter id="mdhwWHzBbE2KzYWxSxhZ3w" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.002">
+                <Parameter id="_gvKKRjuaUy7slDMF9WE-Q" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.002">
                   <Info min="0" max="1" flag="50" seq="1" ref="0" bb="32" group="86" />
                 </Parameter>
               </Children>
@@ -1547,26 +1556,27 @@
               </Tags>
               <Info min="0" max="1" flag="122" seq="22" ref="0" bb="32" group="86" />
             </DistributedParameter>
-            <DistributedParameter id="NFryAj7tA0-1GKRKJicDaw" name="Fraction interstitial" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="4AqJIxOg2km0rEHU06gQiA" mode="Logical" isDefault="1">
+            <DistributedParameter id="Q23HWjaHKEa1xwAtANK0AA" name="Fraction interstitial" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="daZQb5VIJEyK5hJRlIK-YQ" mode="Logical" isDefault="1">
               <Children>
-                <Parameter id="rv-u9FKP8kydTvCGdyo9Cw" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                <Parameter id="rZMlf4XVskWdQ7eWInGu2Q" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
                   <Info min="0" flag="18" seq="1" ref="0" bb="32" group="64" />
                 </Parameter>
-                <Parameter id="RiMhtEbujkmrt7dVs266_w" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.16">
+                <Parameter id="MYmUIAO1j0K-uZNQnuG4vw" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.16">
                   <Info min="0" max="1" flag="50" seq="1" ref="0" bb="32" group="64" />
                 </Parameter>
               </Children>
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
+              <ValueOrigin id="40" source="Publication" description="Edginton, A.N., Schmitt, W. &amp; Willmann, S. Clin Pharmacokinet (2006) 45: 1013. https://doi.org/10.2165/00003088-200645100-00005" />
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             </DistributedParameter>
-            <DistributedParameter id="XaSHU4K92USBv1lj-j0MDg" name="Vf (water)" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="n5m8rL3oT0yL0JEW1uk6MQ" mode="Logical" isDefault="1">
+            <DistributedParameter id="Su-96JiSXk-p8LQdYC6O8w" name="Vf (water)" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ZFbuup721Eq-oTCReXfTaA" mode="Logical" isDefault="1">
               <Children>
-                <Parameter id="Hk20CYR6jka_bK7Lv8grmA" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                <Parameter id="npMw-wLX60GlzC_368k28Q" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
                   <Info min="0" flag="18" seq="1" ref="0" bb="32" group="85" />
                 </Parameter>
-                <Parameter id="7INiSc37d0uToM7Y-plqnQ" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.15">
+                <Parameter id="gZNqeqLrxUSa9XxcVqQeew" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.15">
                   <Info min="0" max="1" flag="50" seq="1" ref="0" bb="32" group="85" />
                 </Parameter>
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@@ -1576,12 +1586,12 @@
               <ValueOrigin id="40" source="Publication" description="Edginton, A.N., Schmitt, W. &amp; Willmann, S. Clin Pharmacokinet (2006) 45: 1013. https://doi.org/10.2165/00003088-200645100-00005" />
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             </DistributedParameter>
-            <DistributedParameter id="_IjU5ufk10WoPdKOoVHfKA" name="Vf (water)-PT" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="s4Ifcj1-ikSDLVNhUQRXCg" mode="Logical" isDefault="1">
+            <DistributedParameter id="HqP_nLwhgkyO_rQkzZaGdw" name="Vf (water)-PT" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="oIOnZTZPa0G3190L26TIXA" mode="Logical" isDefault="1">
               <Children>
-                <Parameter id="hLLs1cPN80eo6rrH3nMELQ" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                <Parameter id="4mXhbht1DU2htcuYI9uSEg" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
                   <Info min="0" flag="18" seq="1" ref="0" bb="32" group="86" />
                 </Parameter>
-                <Parameter id="Wk3qk2kyqEyER-alGnXfdA" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.18">
+                <Parameter id="f7KCswRPCUmgOPqAHtUDlQ" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.18">
                   <Info min="0" max="1" flag="50" seq="1" ref="0" bb="32" group="86" />
                 </Parameter>
               </Children>
@@ -1590,12 +1600,12 @@
               </Tags>
               <Info min="0" max="1" flag="122" seq="23" ref="0" bb="32" group="86" />
             </DistributedParameter>
-            <DistributedParameter id="MrQ7yvpsQUyHwb6Se0QOjg" name="Vf (neutral lipid)-RR" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="121I7D37P0edlArOk9ZA3Q" mode="Logical" isDefault="1">
+            <DistributedParameter id="hE6ccYYw1EOYHyRdJW0N-w" name="Vf (neutral lipid)-RR" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="vbqkT0050EmFJtcJxNOg8Q" mode="Logical" isDefault="1">
               <Children>
-                <Parameter id="cmWJp3-gLEubbtVzbV6ajA" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                <Parameter id="RDmgRBsKvEyP1EOOb41RGw" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
                   <Info min="0" flag="18" seq="1" ref="0" bb="32" group="92" />
                 </Parameter>
-                <Parameter id="cn9lBnwY3U-fQZJZ6XpP5w" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.853">
+                <Parameter id="9F4Am-B0t0ux1TtuABtOiA" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.853">
                   <Info min="0" max="1" flag="50" seq="1" ref="0" bb="32" group="92" />
                 </Parameter>
               </Children>
@@ -1604,12 +1614,12 @@
               </Tags>
               <Info min="0" max="1" flag="122" seq="35" ref="0" bb="32" group="92" />
             </DistributedParameter>
-            <DistributedParameter id="j_7Bx1K5fkKN7a6e3mTx6w" name="Vf (neutral lipid)-WS" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="MkN4-_ex6EmGh9DCsSZZEA" mode="Logical" isDefault="1">
+            <DistributedParameter id="XU6n99InCUGj3RGsbetlrQ" name="Vf (neutral lipid)-WS" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="krmCKCUE6E2WgRfkHGepbg" mode="Logical" isDefault="1">
               <Children>
-                <Parameter id="_jki-fnY1E2VDkORd3B9WA" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                <Parameter id="dKn7l9yuik2xvPesEluErA" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
                   <Info min="0" flag="18" seq="1" ref="0" bb="32" group="95" />
                 </Parameter>
-                <Parameter id="mCcdnehBGkKUHnPZcxXjzQ" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.92">
+                <Parameter id="7_etvhsbvkKi-g2H8Qo0mQ" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.92">
                   <Info min="0" max="1" flag="50" seq="1" ref="0" bb="32" group="95" />
                 </Parameter>
               </Children>
@@ -1618,12 +1628,12 @@
               </Tags>
               <Info min="0" max="1" flag="122" seq="35" ref="0" bb="32" group="95" />
             </DistributedParameter>
-            <DistributedParameter id="yyLh6Hl9tEePa3TJFVExcQ" name="Vf (neutral phospholipid)-RR" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="YzWFqJK0Hkm2U9b7me27ug" mode="Logical" isDefault="1">
+            <DistributedParameter id="LiA-AoeFOk2QKzty1cnsSw" name="Vf (neutral phospholipid)-RR" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Wk2yr-sni0y7wVScaztNQg" mode="Logical" isDefault="1">
               <Children>
-                <Parameter id="LJSeGhIakU-O9qixEYSE4w" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                <Parameter id="F8KuvGbL3Uy-q9kQRIRAhQ" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
                   <Info min="0" flag="18" seq="1" ref="0" bb="32" group="92" />
                 </Parameter>
-                <Parameter id="Jom0mic2TUm_pfZFxmc5ig" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0016">
+                <Parameter id="hbGjGYx_80utbkvSk-1ZVw" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0016">
                   <Info min="0" max="1" flag="50" seq="1" ref="0" bb="32" group="92" />
                 </Parameter>
               </Children>
@@ -1632,12 +1642,12 @@
               </Tags>
               <Info min="0" max="1" flag="122" seq="36" ref="0" bb="32" group="92" />
             </DistributedParameter>
-            <DistributedParameter id="jQbRjPr07EqEhE-sANDufQ" name="Vf (neutral phospholipid, plasma)-WS" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="P5X-6X_GyEOz5P4plJ_F-Q" mode="Logical" isDefault="1">
+            <DistributedParameter id="mxZPKQ5cSkuGgqbQYvTElA" name="Vf (neutral phospholipid, plasma)-WS" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="fAqG5zefrk2LWzS4MRzHCQ" mode="Logical" isDefault="1">
               <Children>
-                <Parameter id="GPqpCxBmPE6Ty6WRSpIdIA" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                <Parameter id="tDj7Vu4IGE-T2OA4VIBYeg" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
                   <Info min="0" flag="18" seq="1" ref="0" bb="32" group="95" />
                 </Parameter>
-                <Parameter id="H8CE0UtQoUOVpG6xlaUi_g" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.002024">
+                <Parameter id="L_AQRL91d0eOLuANkbWBaw" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.002024">
                   <Info min="0" max="1" flag="50" seq="1" ref="0" bb="32" group="95" />
                 </Parameter>
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@@ -1646,12 +1656,12 @@
               </Tags>
               <Info min="0" max="1" flag="122" seq="36" ref="0" bb="32" group="95" />
             </DistributedParameter>
-            <DistributedParameter id="jaKdjPGsJk-xS5G-0sFNqQ" name="Vf (extracellular water)-RR" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="mmgJa3fozUGsPqLWhFjfkw" mode="Logical" isDefault="1">
+            <DistributedParameter id="s3271FgZtkyUvrPV-m-4xQ" name="Vf (extracellular water)-RR" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="cr1SF6dksUynWJGCADf6lQ" mode="Logical" isDefault="1">
               <Children>
-                <Parameter id="I82uX9B2S0WZtFiaK6g1sA" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                <Parameter id="QOW8ICB-XEGK7nWHUbe9Gg" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
                   <Info min="0" flag="18" seq="1" ref="0" bb="32" group="92" />
                 </Parameter>
-                <Parameter id="Fw3mF1owGEex0jFEjNDcNQ" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.135">
+                <Parameter id="BrSLMvMaTEC7_k7Mboh_tg" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.135">
                   <Info min="0" max="1" flag="50" seq="1" ref="0" bb="32" group="92" />
                 </Parameter>
               </Children>
@@ -1660,12 +1670,12 @@
               </Tags>
               <Info min="0" max="1" flag="122" seq="37" ref="0" bb="32" group="92" />
             </DistributedParameter>
-            <DistributedParameter id="1oBpOSzMdEqRy5zzoFfPEg" name="Vf (intracellular water)-RR" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="4lAoxj27TkaC97x0rWmuzQ" mode="Logical" isDefault="1">
+            <DistributedParameter id="uEBWDt7Ly0mWgNLvjsbWBQ" name="Vf (intracellular water)-RR" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="4FT-Bl7wckic17BkH21A4w" mode="Logical" isDefault="1">
               <Children>
-                <Parameter id="bBepISyLp0qwuyUi0LkbRg" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                <Parameter id="Bwr25M4Dv0aTMQapjvJZyg" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
                   <Info min="0" flag="18" seq="1" ref="0" bb="32" group="92" />
                 </Parameter>
-                <Parameter id="HkUUmAQcf0iDYtopSHjtGw" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.00899999999999998">
+                <Parameter id="5XFsBbuOS0eKBZ4NapyDjQ" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.00899999999999998">
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                 </Parameter>
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@@ -1674,12 +1684,12 @@
               </Tags>
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             </DistributedParameter>
-            <DistributedParameter id="lcTN9ZBWQ0Kkmlkhyfq-RA" name="Vf (water)-WS" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="RCfWLLT6GkyEFirACAEgzw" mode="Logical" isDefault="1">
+            <DistributedParameter id="0rI5jqUoMUO31kd-1CAWjg" name="Vf (water)-WS" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ofPaCDRuTkyzMKC1RXYMhg" mode="Logical" isDefault="1">
               <Children>
-                <Parameter id="-16-Z8ZCSUKbvmvUN-JRqw" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                <Parameter id="xt84uhoRm0G9wIWdF8nMBQ" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
                   <Info min="0" flag="18" seq="1" ref="0" bb="32" group="95" />
                 </Parameter>
-                <Parameter id="C3hYDtvYoUmuMYoQ4H9uFA" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.03">
+                <Parameter id="tnz9V393RUCUDXltcv7IIw" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.03">
                   <Info min="0" max="1" flag="50" seq="1" ref="0" bb="32" group="95" />
                 </Parameter>
               </Children>
@@ -1688,138 +1698,139 @@
               </Tags>
               <Info min="0" max="1" flag="122" seq="38" ref="0" bb="32" group="95" />
             </DistributedParameter>
-            <DistributedParameter id="EcCFW9OBqEGjzge5Ixy0mQ" name="Specific blood flow rate" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" formula="fSAEJJCoUUKU4bXAIwsl3Q" mode="Logical" isDefault="1" displayUnit="ml/min/100g organ">
+            <DistributedParameter id="j5XpX96B90yPDLX78MfS2A" name="Specific blood flow rate" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" formula="-pUbyH623kuGtdr88f7jAA" mode="Logical" isDefault="1" displayUnit="ml/min/100g organ">
               <Children>
-                <Parameter id="eOnWlEbSFkCfyyrP3QrTNw" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5" displayUnit="ml/min/100g organ">
+                <Parameter id="jR9PHYrMakuFKsBNpwtlwA" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5" displayUnit="ml/min/100g organ">
                   <Info min="0" flag="18" seq="1" ref="0" bb="32" group="5" />
                 </Parameter>
-                <Parameter id="icmCwzj0_kiVPZzgP1O8xA" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.02184" displayUnit="ml/min/100g organ">
+                <Parameter id="xuCss7tTp0-FWEqKjwaU5A" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.02184" displayUnit="ml/min/100g organ">
                   <Info min="0" flag="50" seq="1" ref="0" bb="32" group="5" />
                 </Parameter>
-                <Parameter id="jMBgzCdcyUeREUvyWLVkog" name="Deviation" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.001092" displayUnit="ml/min/100g organ">
+                <Parameter id="XKGjX4IZw0aimg-sQdz2zA" name="Deviation" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.001092" displayUnit="ml/min/100g organ">
                   <Info min="0" flag="18" seq="1" ref="0" bb="32" group="5" />
                 </Parameter>
               </Children>
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
+              <ValueOrigin id="40" source="Publication" description="Edginton, A.N., Schmitt, W. &amp; Willmann, S. Clin Pharmacokinet (2006) 45: 1013. https://doi.org/10.2165/00003088-200645100-00005" />
               <Info min="0" flag="122" seq="41" ref="0" bb="32" group="5" />
             </DistributedParameter>
-            <Container id="kDtt8apkd0ilEw0l7X3Efw" name="Plasma" mode="Physical" containerType="Compartment">
+            <Container id="eEFhJbl1wESGjgKaGVF2Tw" name="Plasma" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="Fat" />
               </Tags>
               <Children>
-                <Parameter id="Y2RJuikCIEGhqgeSDNFPlA" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                <Parameter id="68Bu-NsjlUmFxrH5U6diqw" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
                   <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                 </Parameter>
-                <Parameter id="lmf9fQWCNUmLuNs32PE1ug" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" isDefault="1" displayUnit="l">
+                <Parameter id="s-wzlN2yF0ulOnmY0XRaIg" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" isDefault="1" displayUnit="l">
                   <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                   <Info min="0" flag="62" seq="7" ref="0" bb="2" group="126" />
                 </Parameter>
-                <Container id="-1_pfFrt00uhls8cDDb5YQ" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="j6gGSS2MQEacWz0Bghf2qA" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                   <Children>
-                    <Parameter id="Oj9hZuXwc0ehqeJ02iESFA" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                    <Parameter id="gTvmixCtCUmchJBeuEa8Gw" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                     </Parameter>
-                    <Parameter id="A8EiLKo_DU2CTmGBLBcAqg" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" isDefault="1">
+                    <Parameter id="s0SJ40AUP0-if8QdQ7V51g" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                     </Parameter>
-                    <Parameter id="tbnE8Rn5E0iAlcHKEeSnug" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
+                    <Parameter id="XIyfhJ_0z06RUazHPN00jA" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
                       <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                     </Parameter>
                   </Children>
                 </Container>
               </Children>
             </Container>
-            <Container id="8gJ8K-5eO0uYBeg7VL1woA" name="BloodCells" mode="Physical" containerType="Compartment">
+            <Container id="aPjmRFIx1UCuIZcC05FS-Q" name="BloodCells" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="Fat" />
               </Tags>
               <Children>
-                <Parameter id="lRp1-3eYiEaqNPsJdrJLzQ" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                <Parameter id="Vlhou46C6kidpLvnzqVBGA" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
                   <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                 </Parameter>
-                <Parameter id="oCeRqyxUk0qIA2lurQ00Wg" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" isDefault="1" displayUnit="l">
+                <Parameter id="jnQHtLoI7k2nDV67z2SMzQ" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" isDefault="1" displayUnit="l">
                   <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                   <Info min="0" flag="62" seq="7" ref="0" bb="2" group="121" />
                 </Parameter>
-                <Container id="hLDRmCjowUyAhMiF4VMnLg" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="MXmX57jTqkquMKUP9y4b1w" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                   <Children>
-                    <Parameter id="rHXKQQhZ8UCSQDf3gkbqxA" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" isDefault="1">
-                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
-                    </Parameter>
-                    <Parameter id="9gBAu60zrkuuVVO0F6Mf_w" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                    <Parameter id="PJKlZYO1Hk-TxPXlLPqJFA" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                     </Parameter>
-                    <Parameter id="dLDXF1pI5EORqlkEPbMyzA" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
+                    <Parameter id="HqPvTARJYE6jlihl5eVCPg" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" isDefault="1">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                    </Parameter>
+                    <Parameter id="R2WgGupiFkSMi5tNNBK6nA" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
                       <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                     </Parameter>
                   </Children>
                 </Container>
               </Children>
             </Container>
-            <Container id="yYLFKBbJQke22TvdmtJWlw" name="Interstitial" mode="Physical" containerType="Compartment">
+            <Container id="SLhuNup-AUWvsW6IFgBIdg" name="Interstitial" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="Fat" />
               </Tags>
               <Children>
-                <Parameter id="dnrxSZL27UGA68UpCELIYA" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                <Parameter id="_0p5g_Pnz0KnRfSJHX9qSQ" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
                   <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                 </Parameter>
-                <Parameter id="XpLHT5sWwEeLrmEDPplgsA" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" isDefault="1" displayUnit="l">
+                <Parameter id="JH2Altr31Uqnis9dJZzvFw" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" isDefault="1" displayUnit="l">
                   <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                   <Info min="0" flag="62" seq="7" ref="0" bb="2" group="124" />
                 </Parameter>
-                <Parameter id="bavYBlR_skOBgSGpzbOkNA" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_pH_INT" isDefault="1">
+                <Parameter id="-1cItHw4CUO23hcRmIZkgQ" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_pH_INT" isDefault="1">
                   <Tags>
                     <Tag value="Fat" />
                   </Tags>
                   <Info min="0" max="14" flag="122" seq="23" ref="0" bb="32" group="84" />
                 </Parameter>
-                <Container id="rxNNTtWJl0O9iL_jYxwBUA" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="17sD1FQ0nUSke5OKpTVmog" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                   <Children>
-                    <Parameter id="aZL0p7ewC0-ZR3-u0Q_U5g" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                    <Parameter id="WzIapGI510qmmL5TarBSdA" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                     </Parameter>
-                    <Parameter id="Oustad1MNkONH5O9w9GvZQ" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_fat" isDefault="1">
+                    <Parameter id="lqnqxnPHuESekJk5Lc7Tuw" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_fat" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                     </Parameter>
-                    <Parameter id="MDd7UN3IZUyKHf4WxsYChg" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
+                    <Parameter id="rUhkqaMgLkmSao-YR8xLaw" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
                       <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                     </Parameter>
                   </Children>
                 </Container>
               </Children>
             </Container>
-            <Container id="P34sCyhx_EC3cvyRjF0o2A" name="Intracellular" mode="Physical" containerType="Compartment">
+            <Container id="5xqprJ-ANESP7f87XxNBsA" name="Intracellular" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="Fat" />
               </Tags>
               <Children>
-                <Parameter id="LTzC5dxjJEKfAEvPJoeQqQ" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" isDefault="1" displayUnit="l">
+                <Parameter id="aIs0eqgpDkWYEqtHt-a3BA" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" isDefault="1" displayUnit="l">
                   <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                 </Parameter>
-                <Parameter id="NmMo0mvH3EqYzhtfdzz2bQ" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" isDefault="1" displayUnit="l">
+                <Parameter id="zsqELReFBk6P346YhcVRNQ" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" isDefault="1" displayUnit="l">
                   <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                   <Info min="0" flag="62" seq="7" ref="0" bb="2" group="125" />
                 </Parameter>
-                <Parameter id="0Fy4liHI4UCQHHb6g8dlOA" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.1">
+                <Parameter id="r_ptmN3w0UehgQ5WMLjj-g" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.1">
                   <Tags>
                     <Tag value="Fat" />
                   </Tags>
                   <ValueOrigin id="34" source="Publication" description="Toxicol In Vitro. 2008 Mar;22(2):457-67 https://doi.org/10.1016/j.tiv.2007.09.010" />
                   <Info min="0" max="14" flag="122" seq="23" ref="0" bb="32" group="83" />
                 </Parameter>
-                <Container id="W57JSLAiT0eNSjo9rIucLw" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="3XTc4Tu9HUaOrqyUKKAE4A" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                   <Children>
-                    <Parameter id="bQgkYN-UAEqPCKhmUHl4pg" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                    <Parameter id="xEo86H_8PEKV-MVWh5A26g" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                     </Parameter>
-                    <Parameter id="bfUrFH23zk64Ye7VdIVaaA" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_fat" isDefault="1">
+                    <Parameter id="1vpwUbG0DUCctOeFCb9o_g" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_fat" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                     </Parameter>
-                    <Parameter id="4q3etEjKv0Ob0gGuBd7QWQ" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
+                    <Parameter id="rxz6rXrruU6EQqz2TVbcLQ" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
                       <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                     </Parameter>
                   </Children>
@@ -1828,398 +1839,400 @@
             </Container>
           </Children>
         </Container>
-        <Container id="Ehcw65bjsE-x186s5Qodug" name="Gonads" mode="Logical" containerType="Organ">
+        <Container id="8ARoSdVniECgeYXSUxEHsA" name="Gonads" mode="Logical" containerType="Organ">
           <Tags>
             <Tag value="TissueOrgan" />
           </Tags>
           <Children>
-            <Parameter id="_AIJ1rM86UmoZpVm2sIoSQ" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
+            <Parameter id="ShpgsmjDbkKOnbw6ropR0Q" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
             </Parameter>
-            <Parameter id="w4LZAK-740SiUt0GK8RDOw" name="Volume (endothelium)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="VascularEndoVolume.VOLUME_VascularEndo_tes" isDefault="1" displayUnit="l">
+            <Parameter id="vzd3ZgTkvkeDOjg7Z6X2NQ" name="Fluid recirculation flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate" isDefault="1" displayUnit="l/min">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
-              <Info min="0" flag="62" seq="10" ref="0" bb="32" group="127" />
+              <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+              <Info min="0" flag="122" seq="10" ref="0" bb="32" group="27" />
             </Parameter>
-            <Parameter id="h5MB8VvhhUW5xnH_9O7wUg" name="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Lymph_flow_rate" isDefault="1" displayUnit="l/min">
+            <Parameter id="G7JsoLZr9kicL1iQA4nd5A" name="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Lymph_flow_rate" isDefault="1" displayUnit="l/min">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
               <Info min="0" flag="122" seq="10" ref="0" bb="32" group="58" />
             </Parameter>
-            <Parameter id="kTD_DLg7oESdCwVYkpVZVg" name="Fluid recirculation flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate" isDefault="1" displayUnit="l/min">
+            <Parameter id="KjZc2-PwjEOC1EfXxLq6ZA" name="Volume (endothelium)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="VascularEndoVolume.VOLUME_VascularEndo_tes" isDefault="1" displayUnit="l">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
-              <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-              <Info min="0" flag="122" seq="10" ref="0" bb="32" group="27" />
+              <Info min="0" flag="62" seq="10" ref="0" bb="32" group="127" />
             </Parameter>
-            <Parameter id="7zZdxjvggEGvKmt4TdEG7g" name="Fraction intracellular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_f_cell" isDefault="1">
+            <Parameter id="FkEAIkaNgUWFhV-JkqNNFg" name="Fraction intracellular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_f_cell" isDefault="1">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" max="1" flag="62" seq="31" ref="0" bb="32" group="64" />
             </Parameter>
-            <Parameter id="TheCMkshy0aMr_j-bzgQ7g" name="Blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_from_Qspec" isDefault="1" displayUnit="l/min">
+            <Parameter id="i_FqH4Fc1kmXUFMS5TaNBA" name="Blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_from_Qspec" isDefault="1" displayUnit="l/min">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
-              <ValueOrigin id="48" description="TODO: Absolute from specific calculation" />
+              <ValueOrigin id="48" source="Other" description="Absolute value = specific value (i.e. value normalized to the volume of the organ) multiplied by the organ volume" />
               <Info min="0" flag="62" seq="62" ref="0" bb="32" group="5" />
             </Parameter>
-            <Parameter id="qN56UZPgrEiMseXknRf3yw" name="Density (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
+            <Parameter id="j6UPdQWWD0atEtVFHVleFg" name="Density (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" flag="38" seq="1" ref="0" bb="32" group="21" />
             </Parameter>
-            <Parameter id="DtQd7cyep0S8hIBJZMMvjQ" name="Fluid recirculation flow proportionality factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.96">
+            <Parameter id="ma9no3XET06qjO5vIeVzDg" name="Fluid recirculation flow proportionality factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.96">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" flag="54" seq="1" ref="0" bb="32" group="27" />
             </Parameter>
-            <Parameter id="vp50imHJHEa9dmMa7VU70w" name="Lymph flow proportionality factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0111">
+            <Parameter id="L_hynZcI20KxYbuDOsiNng" name="Lymph flow proportionality factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0111">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" flag="54" seq="1" ref="0" bb="32" group="58" />
             </Parameter>
-            <Parameter id="ZXldxTYGU0SoZbPCo-iGcA" name="Organ volume mouse" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.00025" displayUnit="l">
+            <Parameter id="8XsSewX6_E649kjJx4lOCA" name="Organ volume mouse" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.00025" displayUnit="l">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
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+                    <Parameter id="2vQOuobkLEKtVNREWYR00A" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
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+                    <Parameter id="K9vicclkYE-Pr9UoWiU8Gw" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" isDefault="1">
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+                    <Parameter id="v-4tAf6XEUmBAKnCTVA5cw" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
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+                <Parameter id="sNMMxUteikO4YgG1zLuefA" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
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+                <Parameter id="mK9GNJMRiUCUckVi_GzHig" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" isDefault="1" displayUnit="l">
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+                    <Parameter id="crcRnnpyGkugFd_Cpf3k5w" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
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+                    <Parameter id="MK4ka1QSc0ODIwC_J29HBg" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" isDefault="1">
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+                    <Parameter id="XokKSYgBvE6H3VQt6h5A6w" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
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-            <Container id="kD2zuevSS0mRrrijXqriPQ" name="Interstitial" mode="Physical" containerType="Compartment">
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               <Tags>
                 <Tag value="Gonads" />
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+                <Parameter id="lwvd4RWWdk62zbM1d6_JQg" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
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+                <Parameter id="U-kvKnlxkECr2lR4XSh3mA" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" isDefault="1" displayUnit="l">
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+                <Parameter id="WTZlRbv7AUCkTdj-chIQTg" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_pH_INT" isDefault="1">
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+                <Container id="uDjYhbPQdku0iTFDRN3hmw" name="MoleculeProperties" mode="Logical" containerType="Molecule">
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+                    <Parameter id="kPJjRxuW5kybbxUpmg3EKA" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
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+                    <Parameter id="7Ikw6XKHkUSkEuiG8PGaIw" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_tes" isDefault="1">
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+                    <Parameter id="CD0aaFLvTkmVoSIMbwdT5Q" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
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-            <Container id="0b9PfDC8l0O6nirtF8OPnA" name="Intracellular" mode="Physical" containerType="Compartment">
+            <Container id="rkoI-pNzb0mlJoIUsPyNPw" name="Intracellular" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="Gonads" />
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+                <Parameter id="XSJX12N5xU-UaGZkpiYZZg" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" isDefault="1" displayUnit="l">
                   <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
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+                <Parameter id="Hv0RFk-N2kOXiIn2baRTWg" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" isDefault="1" displayUnit="l">
                   <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
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-                <Parameter id="bK6aZa3KAEy5cd0x8z1RxQ" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7">
+                <Parameter id="EnPmxSQ8jUmhKQsHQSU0fQ" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7">
                   <Tags>
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                 </Parameter>
-                <Container id="8d6XoYVW9k-shBZx5J_71A" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="YARcc3U20kaaCLPgK7MEWA" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                   <Children>
-                    <Parameter id="EnK16U5nGUS2BHCXfZL6YQ" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                    <Parameter id="wYX35P67b0SUnbalOhKfTQ" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                     </Parameter>
-                    <Parameter id="32A19HVIxE6HMbgYxR1enA" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_tes" isDefault="1">
+                    <Parameter id="JZKrxOltNk68sA-KMaKnVw" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_tes" isDefault="1">
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+                    <Parameter id="Fatks83r7U6CQSFuaHr0vg" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
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@@ -2228,402 +2241,404 @@
             </Container>
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-        <Container id="jplQy8FzsUuFKpv7H2U4pQ" name="Heart" mode="Logical" containerType="Organ">
+        <Container id="DfEuyxdIFESY4aZW-YhKdw" name="Heart" mode="Logical" containerType="Organ">
           <Tags>
             <Tag value="TissueOrgan" />
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+            <Parameter id="9xlk7ZKocEma9XO-uht-IA" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
               <Tags>
                 <Tag value="TissueOrgan" />
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               <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
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-            <Parameter id="dZmIBQFKCUigAVslHmDecw" name="Fluid recirculation flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate" isDefault="1" displayUnit="l/min">
+            <Parameter id="csYpEeblIUSXf-bw5xpJ4g" name="Fluid recirculation flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate" isDefault="1" displayUnit="l/min">
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+            <Parameter id="pBt7TEpfcUekCbtLVss_fw" name="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Lymph_flow_rate" isDefault="1" displayUnit="l/min">
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             </Parameter>
-            <Parameter id="HfndTe9bKkKOqeM6Ah7V7Q" name="Volume (endothelium)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="VascularEndoVolume.VOLUME_VascularEndo_hrt" isDefault="1" displayUnit="l">
+            <Parameter id="yc7FyITjHUe4AbC5ZpES-g" name="Volume (endothelium)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="VascularEndoVolume.VOLUME_VascularEndo_hrt" isDefault="1" displayUnit="l">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" flag="62" seq="11" ref="0" bb="32" group="127" />
             </Parameter>
-            <Parameter id="Nxg_Hd8kNUSwu_5D8Vlhjw" name="Fraction intracellular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_f_cell" isDefault="1">
+            <Parameter id="Roo8HeVvAUGMpTf9_mUPmg" name="Fraction intracellular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_f_cell" isDefault="1">
               <Tags>
                 <Tag value="TissueOrgan" />
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               <Info min="0" max="1" flag="62" seq="34" ref="0" bb="32" group="64" />
             </Parameter>
-            <Parameter id="jNoYc0YEYUKgLaV7ZleKaA" name="Blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_from_Qspec" isDefault="1" displayUnit="l/min">
+            <Parameter id="jGODHr72F06yY9L9oGj2Dg" name="Blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_from_Qspec" isDefault="1" displayUnit="l/min">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
-              <ValueOrigin id="48" description="TODO: Absolute from specific calculation" />
+              <ValueOrigin id="48" source="Other" description="Absolute value = specific value (i.e. value normalized to the volume of the organ) multiplied by the organ volume" />
               <Info min="0" flag="62" seq="82" ref="0" bb="32" group="5" />
             </Parameter>
-            <Parameter id="Mrnt66upfkutmwCNVRAxMA" name="Density (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
+            <Parameter id="5UbhRtT7GkK46ey-_ihftw" name="Density (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
               <Tags>
                 <Tag value="TissueOrgan" />
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               <Info min="0" flag="38" seq="1" ref="0" bb="32" group="21" />
             </Parameter>
-            <Parameter id="tI1N1RmRt0GHQ4VGmL-XrA" name="Fluid recirculation flow proportionality factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.96">
+            <Parameter id="XdfUh-HmW06jcY_2Cn167w" name="Fluid recirculation flow proportionality factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.96">
               <Tags>
                 <Tag value="TissueOrgan" />
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               <Info min="0" flag="54" seq="1" ref="0" bb="32" group="27" />
             </Parameter>
-            <Parameter id="SXHvY_D8a06jpnVqZwdpPg" name="Organ volume mouse" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="9.5E-05" displayUnit="l">
+            <Parameter id="_gbFxowjKkWXVgEickZc3g" name="Lymph flow proportionality factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.00147">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
-              <Info min="0" flag="54" seq="1" ref="0" bb="32" group="65" />
+              <Info min="0" flag="54" seq="1" ref="0" bb="32" group="58" />
             </Parameter>
-            <Parameter id="yjiuWltvoUan_JFPU-2fFQ" name="Lymph flow proportionality factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.00147">
+            <Parameter id="U-EfPGYkOkGc2DvPB_D1KQ" name="Organ volume mouse" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="9.5E-05" displayUnit="l">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
-              <Info min="0" flag="54" seq="1" ref="0" bb="32" group="58" />
+              <Info min="0" flag="54" seq="1" ref="0" bb="32" group="65" />
             </Parameter>
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+            <Parameter id="o56JmGN8Y0awXw9AmqmvFw" name="Allometric scale factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.75">
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               <Info min="0.75" max="0.75" flag="54" seq="1" ref="0" bb="32" group="2" />
             </Parameter>
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+            <Parameter id="6wrA1UeomkGBXV2d4i_qrQ" name="Fraction of blood for sampling" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
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                 <Tag value="TissueOrgan" />
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               <Info min="0" max="1" flag="54" seq="1" ref="0" bb="32" group="94" />
             </Parameter>
-            <Parameter id="hh56lryKa023JTDBoic9Ag" name="Radius (small pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="4.5E-08" displayUnit="µm">
+            <Parameter id="t8S44diLGUWO24AXaKtNTQ" name="Flow fraction via large pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.05">
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-              <Info min="0" flag="122" seq="11" ref="0" bb="32" group="99" />
+              <Info min="0" max="1" flag="122" seq="11" ref="0" bb="32" group="114" />
             </Parameter>
-            <Parameter id="D8fykA600kCHVgSkduQZcw" name="Radius (large pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.5E-07" displayUnit="µm">
+            <Parameter id="-zlZ83hkFUCoM_8aR8ztXg" name="Hydraulic conductivity" icon="Parameter" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.43333333333333E-11" displayUnit="ml/min/N">
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-              <Info min="0" flag="122" seq="11" ref="0" bb="32" group="55" />
+              <Info min="0" flag="122" seq="11" ref="0" bb="32" group="115" />
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+            <Parameter id="xrBdwIVIWECdWHk0CyNIuQ" name="Radius (large pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.5E-07" displayUnit="µm">
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-              <Info min="0" max="1" flag="122" seq="11" ref="0" bb="32" group="114" />
+              <Info min="0" flag="122" seq="11" ref="0" bb="32" group="55" />
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-            <Parameter id="bx-IY01Ia0mRUakG-49bkg" name="Hydraulic conductivity" icon="Parameter" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.43333333333333E-11" displayUnit="ml/min/N">
+            <Parameter id="cGA1KNGLLUOQOn5BXI1KPQ" name="Radius (small pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="4.5E-08" displayUnit="µm">
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-              <Info min="0" flag="122" seq="11" ref="0" bb="32" group="115" />
+              <Info min="0" flag="122" seq="11" ref="0" bb="32" group="99" />
             </Parameter>
-            <Parameter id="IaVnTPUTtkSiGHrtv4as3w" name="Vf (neutral lipid)-PT" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0115">
+            <Parameter id="H3j9c95GkE2ok0z7bJdyyA" name="Fraction vascular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.14">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
-              <Info min="0" max="1" flag="122" seq="33" ref="0" bb="32" group="86" />
+              <ValueOrigin id="40" source="Publication" description="Edginton, A.N., Schmitt, W. &amp; Willmann, S. Clin Pharmacokinet (2006) 45: 1013. https://doi.org/10.2165/00003088-200645100-00005" />
+              <Info min="0" max="1" flag="62" seq="33" ref="0" bb="32" group="64" />
             </Parameter>
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+            <Parameter id="PUocYb2jxUuD44JUa2dXdg" name="Vf (lipid)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.1">
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               <Info min="0" max="1" flag="122" seq="33" ref="0" bb="32" group="85" />
             </Parameter>
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+            <Parameter id="JepXD2Xta0SDYmk-S3A2cg" name="Vf (neutral lipid)-PT" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0115">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
-              <ValueOrigin id="40" source="Publication" description="Edginton, A.N., Schmitt, W. &amp; Willmann, S. Clin Pharmacokinet (2006) 45: 1013. https://doi.org/10.2165/00003088-200645100-00005" />
-              <Info min="0" max="1" flag="62" seq="33" ref="0" bb="32" group="64" />
+              <Info min="0" max="1" flag="122" seq="33" ref="0" bb="32" group="86" />
             </Parameter>
-            <Parameter id="kIaNr--NJkKHh79uiWCcIg" name="Vf (phospholipid)-PT" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0166">
+            <Parameter id="KFCiqbGLi0O3QVSU1S9-Mg" name="Vf (phospholipid)-PT" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0166">
               <Tags>
                 <Tag value="TissueOrgan" />
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               <Info min="0" max="1" flag="122" seq="34" ref="0" bb="32" group="86" />
             </Parameter>
-            <Parameter id="10sx7n7nIEGERNvySFuFSw" name="Vf (protein)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.168">
+            <Parameter id="oCiFmdy3s0GU5vuT4WaFAA" name="Vf (protein)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.168">
               <Tags>
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               </Tags>
               <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
               <Info min="0" max="1" flag="122" seq="34" ref="0" bb="32" group="85" />
             </Parameter>
-            <Parameter id="uDyopB_To0-qVx-MWt7G6A" name="Albumin ratio (tissue/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.157">
+            <Parameter id="hZgXnS6tM0uRt2azp9MSOQ" name="Fraction interstitial" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.1">
+              <Tags>
+                <Tag value="TissueOrgan" />
+              </Tags>
+              <ValueOrigin id="19" source="Publication" description="Kawai R, Lemaire M, Steimer JL, Bruelisauer A, Niederberger W, Rowland M. Physiologically based pharmacokinetic study on a cyclosporin derivative, SDZ IMM 125. J Pharmacokinet Biopharm. 1994 Oct;22(5):327-65." />
+              <Info min="0" max="1" flag="62" seq="35" ref="0" bb="32" group="64" />
+            </Parameter>
+            <Parameter id="T9T_0fkffEyIMqcGdwHhNg" name="Albumin ratio (tissue/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.157">
               <Tags>
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               </Tags>
               <ValueOrigin id="22" source="Publication" description="Rodgers T, Rowland M. Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J Pharm Sci. 2006 Jun;95(6):1238-57 https://doi.org/10.1002/jps.20502" />
               <Info min="0" max="1" flag="122" seq="35" ref="0" bb="32" group="111" />
             </Parameter>
-            <Parameter id="4MHL1uaV10aDGUNz9U1Lig" name="Albumin ratio (tissue/plasma)-PT" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+            <Parameter id="4-nZkOwACkqP-VgIRUNowg" name="Albumin ratio (tissue/plasma)-PT" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
               <Tags>
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               <ValueOrigin id="24" source="Publication" description="POULIN P, THEIL F. Prediction of Pharmacokinetics Prior to In Vivo Studies. 1. Mechanism-Based Prediction of Volume of Distribution. JOURNAL OF PHARMACEUTICAL SCIENCES, VOL. 91, NO. 1, JANUARY 2002" />
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             </Parameter>
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+            <Parameter id="VMCvmrX0KEKu5dr6-OzgMA" name="Lipoprotein ratio (tissue/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.16">
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+            <Parameter id="GTsn8rcPoUqJ2MoG6Wsijw" name="Vf (water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.731">
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-              <Info min="0" max="1" flag="62" seq="35" ref="0" bb="32" group="64" />
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+              <Info min="0" max="1" flag="122" seq="55" ref="0" bb="32" group="92" />
             </Parameter>
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+            <Parameter id="QJjoxQHTOEenU2wx8kzZtg" name="Vf (neutral phospholipid, plasma)-WS" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0473">
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+            <Parameter id="RQs3KF4ZCUycw4v-RwUujQ" name="Vf (extracellular water)-RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.32">
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-                <Parameter id="apMeVFxzhUufz0DBTZ2AWQ" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" isDefault="1" displayUnit="l">
+                <Parameter id="jT_nPGY_jUOrs_W25L29mw" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" isDefault="1" displayUnit="l">
                   <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                   <Info min="0" flag="62" seq="11" ref="0" bb="2" group="125" />
                 </Parameter>
-                <Parameter id="tkfYf4nUxEuFPZs4MRC3YA" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.1">
+                <Parameter id="4N0z-AUfS0yrQkH54AJk7Q" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.1">
                   <Tags>
                     <Tag value="Heart" />
                   </Tags>
                   <ValueOrigin id="34" source="Publication" description="Toxicol In Vitro. 2008 Mar;22(2):457-67 https://doi.org/10.1016/j.tiv.2007.09.010" />
                   <Info min="0" max="14" flag="122" seq="35" ref="0" bb="32" group="83" />
                 </Parameter>
-                <Container id="rZZzgYpWB0mb3M50TrwjDQ" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="-Oy9IXr9l0CJiZXPSdnlxQ" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                   <Children>
-                    <Parameter id="GYZ2FUkFzk-GmJKHSrm05A" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                    <Parameter id="vIbaLFSE2kGKN24aIyiheA" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                     </Parameter>
-                    <Parameter id="lhiZsA9RzEmyotyec8izyw" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_hrt" isDefault="1">
+                    <Parameter id="XL3gItluIEWR7Z1SfC1CDQ" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_hrt" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                     </Parameter>
-                    <Parameter id="X6efiqpPK06n7vcX6oVEdA" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
+                    <Parameter id="Ulp8NXtI9katntBSZA39bA" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
                       <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                     </Parameter>
                   </Children>
@@ -2632,377 +2647,375 @@
             </Container>
           </Children>
         </Container>
-        <Container id="riiFRyJwzkyYJZwO5iWmsQ" name="Kidney" mode="Logical" containerType="Organ">
+        <Container id="-hucya2pAEOvW0INj7YQdw" name="Kidney" mode="Logical" containerType="Organ">
           <Tags>
             <Tag value="TissueOrgan" />
           </Tags>
           <Children>
-            <Parameter id="3pk47CZS6kS6itSvPjPSLQ" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
+            <Parameter id="Nett48Yta0CzY2QKrbYZeA" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
             </Parameter>
-            <Parameter id="ScTZFmXHqk-3WD5g8xSy9g" name="Volume (endothelium)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="VascularEndoVolume.VOLUME_VascularEndo_kid" isDefault="1" displayUnit="l">
+            <Parameter id="7t0xUL5E8U-jFc3YJ2OXEw" name="Fluid recirculation flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate" isDefault="1" displayUnit="l/min">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
-              <Info min="0" flag="62" seq="12" ref="0" bb="32" group="127" />
+              <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+              <Info min="0" flag="122" seq="12" ref="0" bb="32" group="27" />
             </Parameter>
-            <Parameter id="r2G9gRDgiUOnCtx0wVefqQ" name="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Lymph_flow_rate" isDefault="1" displayUnit="l/min">
+            <Parameter id="HF2NrXWOb0OVKRm2KV6zgA" name="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Lymph_flow_rate" isDefault="1" displayUnit="l/min">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
               <Info min="0" flag="122" seq="12" ref="0" bb="32" group="58" />
             </Parameter>
-            <Parameter id="GcBVBpIv6kSKBXFFR9zxXQ" name="Fluid recirculation flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate" isDefault="1" displayUnit="l/min">
+            <Parameter id="rJ2vLZb5zUCCD3eoiWwh4g" name="Volume (endothelium)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="VascularEndoVolume.VOLUME_VascularEndo_kid" isDefault="1" displayUnit="l">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
-              <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-              <Info min="0" flag="122" seq="12" ref="0" bb="32" group="27" />
+              <Info min="0" flag="62" seq="12" ref="0" bb="32" group="127" />
             </Parameter>
-            <Parameter id="R5Vm9cPZR0uBnqx3DQzLKw" name="Fraction intracellular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_f_cell" isDefault="1">
+            <Parameter id="zTT0DuXD-kyLsRbkIoetgg" name="Fraction intracellular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_f_cell" isDefault="1">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" max="1" flag="62" seq="37" ref="0" bb="32" group="64" />
             </Parameter>
-            <Parameter id="6ymlb76mmk6PndnS8_IE3A" name="Renal aging scaling factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Renal_Aging_Human.Renal aging factor" isDefault="1">
+            <Parameter id="8YNp7etVKkKggiR7ppE5mQ" name="GFR" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="GFR_Calculation.PARAM_GFR" isDefault="1" displayUnit="ml/min">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
-              <Info min="0" max="1" flag="52" seq="99" ref="0" bb="32" group="30" />
+              <Info min="0" flag="60" seq="99" ref="0" bb="32" group="30" />
             </Parameter>
-            <Parameter id="a2T-WDFBEE-rvWOua0rk1g" name="GFR" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="GFR_Calculation.PARAM_GFR" isDefault="1" displayUnit="ml/min">
+            <Parameter id="Blq4Muic5EaAoP0jsjeW0w" name="GFR (specific)" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" formula="GFR_Calculation.PARAM_GFR_Spec" isDefault="1" displayUnit="ml/min/100g organ">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
-              <Info min="0" flag="60" seq="99" ref="0" bb="32" group="30" />
+              <ValueOrigin id="15" source="Publication" description="Schlender J-F, Meyer M, et al. Development of a Whole-Body Physiologically Based Pharmacokinetic Approach to Assess the Pharmacokinetics of Drugs in Elderly Individuals. Clinical Pharmacokinetics. 2016;55(12):1573-1589. doi:10.1007/s40262-016-0422-3" />
+              <Info min="0" flag="122" seq="99" ref="0" bb="32" group="30" />
             </Parameter>
-            <Parameter id="TaXY1oIaAECjyly10PQIHg" name="GFR (specific)" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" formula="GFR_Calculation.PARAM_GFR_Spec" isDefault="1" displayUnit="ml/min/100g organ">
+            <Parameter id="pEUces3RhEqwqkXYFHxEXw" name="Renal aging scaling factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Renal_Aging_Human.Renal aging factor" isDefault="1">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
-              <ValueOrigin id="15" source="Publication" description="Schlender J-F, Meyer M, et al. Development of a Whole-Body Physiologically Based Pharmacokinetic Approach to Assess the Pharmacokinetics of Drugs in Elderly Individuals. Clinical Pharmacokinetics. 2016;55(12):1573-1589. doi:10.1007/s40262-016-0422-3" />
-              <Info min="0" flag="122" seq="99" ref="0" bb="32" group="30" />
+              <Info min="0" max="1" flag="52" seq="99" ref="0" bb="32" group="30" />
             </Parameter>
-            <Parameter id="tA53JCXjO0aJtEunN3viFQ" name="Blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_from_Qspec" isDefault="1" displayUnit="l/min">
+            <Parameter id="h2mB6looe0KeLmpB6NEDFA" name="Blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_from_Qspec" isDefault="1" displayUnit="l/min">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
-              <ValueOrigin id="48" description="TODO: Absolute from specific calculation" />
+              <ValueOrigin id="48" source="Other" description="Absolute value = specific value (i.e. value normalized to the volume of the organ) multiplied by the organ volume" />
               <Info min="0" flag="62" seq="102" ref="0" bb="32" group="5" />
             </Parameter>
-            <Parameter id="IfkPei4w_0ujn3DVvOWDAQ" name="Density (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
+            <Parameter id="fu6c-g43bUy59oEX9r3Xdg" name="Density (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" flag="38" seq="1" ref="0" bb="32" group="21" />
             </Parameter>
-            <Parameter id="RHlBuvCtt0KYz99REVeuxQ" name="Fluid recirculation flow proportionality factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.761">
+            <Parameter id="MtaoSDkZmEaG8i4TuyWleQ" name="Fluid recirculation flow proportionality factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.761">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" flag="54" seq="1" ref="0" bb="32" group="27" />
             </Parameter>
-            <Parameter id="9_kCHcbDG0WY9NX69jfmTg" name="Lymph flow proportionality factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.000709">
+            <Parameter id="1GWePxT0LEqXSrDpi-BqDg" name="Lymph flow proportionality factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.000709">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" flag="54" seq="1" ref="0" bb="32" group="58" />
             </Parameter>
-            <Parameter id="tjrb4HcY30-gyZkxRmQBZw" name="Organ volume mouse" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.00034" displayUnit="l">
+            <Parameter id="HDEmKEQ-5UGFJ0im404u_Q" name="Organ volume mouse" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.00034" displayUnit="l">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" flag="54" seq="1" ref="0" bb="32" group="65" />
             </Parameter>
-            <Parameter id="15cu-fyh90687g7kslYSAw" name="Allometric scale factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.75">
+            <Parameter id="LD07yXSS1UKeTEw4vIIxIA" name="Allometric scale factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.75">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0.75" max="0.75" flag="54" seq="1" ref="0" bb="32" group="2" />
             </Parameter>
-            <Parameter id="OyLh46dKP0SO_uL4agbplw" name="Volume (standard kidney)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.44" displayUnit="l">
+            <Parameter id="stAQeveroUezd4t56QvD1Q" name="Volume (standard kidney)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.44" displayUnit="l">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" flag="52" seq="1" ref="0" bb="32" group="6" />
             </Parameter>
-            <Parameter id="pux_VRqA3EuTaTkgzrjWCA" name="Fraction of blood for sampling" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+            <Parameter id="lNrN_uF_MUixGGUhbFbmgg" name="Fraction of blood for sampling" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" max="1" flag="54" seq="1" ref="0" bb="32" group="94" />
             </Parameter>
-            <Parameter id="h9QpmkWzFkSPJwVcpvifwQ" name="Radius (small pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="4.5E-08" displayUnit="µm">
+            <Parameter id="J_cuMP7nVEa-Ca8ufmwMKA" name="Flow fraction via large pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.05">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-              <Info min="0" flag="122" seq="12" ref="0" bb="32" group="99" />
+              <Info min="0" max="1" flag="122" seq="12" ref="0" bb="32" group="114" />
             </Parameter>
-            <Parameter id="z2_WBXN3_kG71qx7g4t3IQ" name="Radius (large pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.5E-07" displayUnit="µm">
+            <Parameter id="UF6FkWVtAUyfWEWjxpx3uQ" name="Hydraulic conductivity" icon="Parameter" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.25E-10" displayUnit="ml/min/N">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-              <Info min="0" flag="122" seq="12" ref="0" bb="32" group="55" />
+              <Info min="0" flag="122" seq="12" ref="0" bb="32" group="115" />
             </Parameter>
-            <Parameter id="hpEi86wQt0uXCi23mmaBRQ" name="Hydraulic conductivity" icon="Parameter" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.25E-10" displayUnit="ml/min/N">
+            <Parameter id="lmxFvpdrXUykdC5zBhpq4g" name="Radius (large pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.5E-07" displayUnit="µm">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-              <Info min="0" flag="122" seq="12" ref="0" bb="32" group="115" />
+              <Info min="0" flag="122" seq="12" ref="0" bb="32" group="55" />
             </Parameter>
-            <Parameter id="J2bAw4A_cEGG1H8LUMLkJw" name="Flow fraction via large pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.05">
+            <Parameter id="g4oYbkS-BUq5vpuQ9pqoqA" name="Radius (small pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="4.5E-08" displayUnit="µm">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-              <Info min="0" max="1" flag="122" seq="12" ref="0" bb="32" group="114" />
+              <Info min="0" flag="122" seq="12" ref="0" bb="32" group="99" />
+            </Parameter>
+            <Parameter id="YD-ykdv8U06SQRu178wjzA" name="Fraction vascular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.23">
+              <Tags>
+                <Tag value="TissueOrgan" />
+              </Tags>
+              <ValueOrigin id="40" source="Publication" description="Edginton, A.N., Schmitt, W. &amp; Willmann, S. Clin Pharmacokinet (2006) 45: 1013. https://doi.org/10.2165/00003088-200645100-00005" />
+              <Info min="0" max="1" flag="62" seq="36" ref="0" bb="32" group="64" />
             </Parameter>
-            <Parameter id="voq0GqaWL0CzqR7Dz8BhIg" name="Vf (lipid)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.052">
+            <Parameter id="rg3B6qIEaEyXUcsGZ9cvhQ" name="Vf (lipid)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.052">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
               <Info min="0" max="1" flag="122" seq="36" ref="0" bb="32" group="85" />
             </Parameter>
-            <Parameter id="El0WchGgyEyHqovuPXAHKQ" name="Vf (neutral lipid)-PT" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0207">
+            <Parameter id="2YdluDIDp06C5uV40KdD2g" name="Vf (neutral lipid)-PT" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0207">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" max="1" flag="122" seq="36" ref="0" bb="32" group="86" />
             </Parameter>
-            <Parameter id="13eIPtOksUucwyVoIrU2HQ" name="Fraction vascular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.23">
+            <Parameter id="KCaY-xWphkOOt_w_XLAi7w" name="Vf (phospholipid)-PT" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0162">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
-              <ValueOrigin id="40" source="Publication" description="Edginton, A.N., Schmitt, W. &amp; Willmann, S. Clin Pharmacokinet (2006) 45: 1013. https://doi.org/10.2165/00003088-200645100-00005" />
-              <Info min="0" max="1" flag="62" seq="36" ref="0" bb="32" group="64" />
+              <Info min="0" max="1" flag="122" seq="37" ref="0" bb="32" group="86" />
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+                    <Parameter id="EYvRihu2XEa2XCyhsiT-kQ" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
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                     </Parameter>
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+                    <Parameter id="GBckYEXXDUeuPCk2Y8IBmw" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" isDefault="1">
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                     </Parameter>
-                    <Parameter id="H7ii4fdTB0GqgfIKRitE2w" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
+                    <Parameter id="FR93QbKHaUSxNngNeLvqTw" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
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                   </Children>
                 </Container>
               </Children>
             </Container>
-            <Container id="-lLRMLxBgUaEHr61uidqtQ" name="Interstitial" mode="Physical" containerType="Compartment">
+            <Container id="MPgIXNyqo0qosyQtvRmg_Q" name="Interstitial" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="Kidney" />
               </Tags>
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-                <Parameter id="iAPxd1UUU0Suqoj7enkf8w" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                <Parameter id="hEYq95hSL0qpZBx3yYKhqg" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
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                 </Parameter>
-                <Parameter id="Ugl9jcWi5EGxP_sKCM3UZA" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" isDefault="1" displayUnit="l">
+                <Parameter id="yod6xuEsa0CiIi_t3mYFHQ" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" isDefault="1" displayUnit="l">
                   <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                   <Info min="0" flag="62" seq="12" ref="0" bb="2" group="124" />
                 </Parameter>
-                <Parameter id="GHVLpXMGdEan-sG8CYUWgw" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_pH_INT" isDefault="1">
+                <Parameter id="suvdGSkt1U6_NxD2dGYlsg" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_pH_INT" isDefault="1">
                   <Tags>
                     <Tag value="Kidney" />
                   </Tags>
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                 </Parameter>
-                <Container id="1_31phz040mxEgI7TRITQw" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="hA6P1FJtwUqpDlWVTh29Ew" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                   <Children>
-                    <Parameter id="DwTu2tPL7kq3HuLScdKq4w" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
-                      <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
-                    </Parameter>
-                    <Parameter id="fXZQnt-siUm_BkmtXgFd9g" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                    <Parameter id="CXY3GLCFxUuklk5O7gZxcA" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                     </Parameter>
-                    <Parameter id="WIh6UQ9w50CdB6KonBESTQ" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_kid" isDefault="1">
+                    <Parameter id="KLbzjV_IwEGvRj6cf-C77Q" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_kid" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                     </Parameter>
+                    <Parameter id="UHyRi8WNzE6z0hLVDK2cNw" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
+                      <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                    </Parameter>
                   </Children>
                 </Container>
               </Children>
             </Container>
-            <Container id="e29IxhujBkyWy3T1E7lgZw" name="Intracellular" mode="Physical" containerType="Compartment">
+            <Container id="8Y6EVjFoqEmjiDi4BEwtgQ" name="Intracellular" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="Kidney" />
               </Tags>
               <Children>
-                <Parameter id="DFlOPON9H0St5QEK0cXUaA" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" isDefault="1" displayUnit="l">
+                <Parameter id="GeLGwoWkFEeesy9wzYrIzA" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" isDefault="1" displayUnit="l">
                   <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                 </Parameter>
-                <Parameter id="9Qd3IHDRf0KzkByNVAUUFQ" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" isDefault="1" displayUnit="l">
+                <Parameter id="ysAGR-zrDk6wvKY68PO0zw" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" isDefault="1" displayUnit="l">
                   <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                   <Info min="0" flag="62" seq="12" ref="0" bb="2" group="125" />
                 </Parameter>
-                <Parameter id="QjkxoUCL20uEgyQtPov8cg" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.22">
+                <Parameter id="DNSZquL8IUyJpGuv89ln1g" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.22">
                   <Tags>
                     <Tag value="Kidney" />
                   </Tags>
                   <ValueOrigin id="34" source="Publication" description="Toxicol In Vitro. 2008 Mar;22(2):457-67 https://doi.org/10.1016/j.tiv.2007.09.010" />
                   <Info min="0" max="14" flag="122" seq="38" ref="0" bb="32" group="83" />
                 </Parameter>
-                <Container id="H7uSqkGeR0K8D_bokb1B0g" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="EyIzmlz9ZUCLLerh1sxGQA" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                   <Children>
-                    <Parameter id="biya8r0qeEq6uaOqAq1b4A" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_kid" isDefault="1">
-                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
-                    </Parameter>
-                    <Parameter id="_liUg59EQUOmPjb9KXFAPA" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                    <Parameter id="8ZP_dxv_gkeR8LcnRAuTkg" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                     </Parameter>
-                    <Parameter id="e6nAvKk-xkugH_e5mssJ2A" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
+                    <Parameter id="slGSM6epykmlnpauOqDBYQ" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_kid" isDefault="1">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                    </Parameter>
+                    <Parameter id="IohCT7eobkG67W2iFPLPfw" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
                       <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                     </Parameter>
                   </Children>
                 </Container>
               </Children>
             </Container>
-            <Container id="7ijrxaKvTE-h8IMoZRddOA" name="Urine" mode="Physical" containerType="Compartment">
+            <Container id="3F0-FJLEU0-S4f5_pji2aw" name="Urine" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="Kidney" />
               </Tags>
               <Children>
-                <Parameter id="M3l2N3MvF0WlM6CPkSRGIQ" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="l">
+                <Parameter id="LVRtdtTcwUuCBVTiByCGxg" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="l">
                   <Info min="0" flag="54" seq="666" ref="0" bb="2" group="65" />
                 </Parameter>
-                <Container id="YbD1E6mr4k63HIXg3WwazQ" name="MoleculeProperties" mode="Logical" containerType="Molecule" />
+                <Container id="oRVvFZDtPUufuzT2DBroLA" name="MoleculeProperties" mode="Logical" containerType="Molecule" />
               </Children>
             </Container>
           </Children>
         </Container>
-        <Container id="cyXXIGRoMkGj6vla9-Y1Vw" name="Lumen" mode="Logical" containerType="Organ">
+        <Container id="EsbRRCVsgkGTthH86TPgdA" name="Lumen" mode="Logical" containerType="Organ">
           <Children>
-            <Parameter id="n6ATay3WmUiOocFjtqLrLg" name="OralApplicationsEnabled" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+            <Parameter id="gsw9mTHF5k6WV8RLivlGfw" name="OralApplicationsEnabled" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
               <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="63" />
             </Parameter>
-            <Parameter id="U9LLFTijrkWIHoYkt8OLhQ" name="Paracellular absorption sink condition" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+            <Parameter id="GtmFZdORWEKUY1RMiMBMCw" name="Paracellular absorption sink condition" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
               <Info min="0" max="1" flag="58" seq="1" ref="0" bb="2" group="39" />
             </Parameter>
-            <Parameter id="1wCyZyhpm0qykmwq3txwAQ" name="Transcellular absorption sink condition" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+            <Parameter id="Y2LChNKqs0i9iDRKx6o4GQ" name="Transcellular absorption sink condition" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
               <Info min="0" max="1" flag="58" seq="1" ref="0" bb="2" group="39" />
             </Parameter>
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+            <DistributedParameter id="tDXx-EffckOkCcLg_Jf55w" name="Effective surface area variability factor" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="5s_W5CP-rEWpKB7LnCr1eQ" mode="Logical" isDefault="1">
               <Children>
-                <Parameter id="1OjKoFDDC0Ky9R0Pdg4Y0Q" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                <Parameter id="vQB93Xx2pkCYGYHGJMO5bA" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
                   <Info min="0" flag="18" seq="1" ref="0" bb="32" group="144" />
                 </Parameter>
-                <Parameter id="FpiThqEgbEy6l-6V0JMLDQ" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                <Parameter id="xlW83FfBNUi9cPdHnRJ-6g" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
                   <Info min="0" flag="34" seq="1" ref="0" bb="32" group="144" />
                 </Parameter>
-                <Parameter id="_scCI5vOnUuUcXNezIHU6Q" name="GeometricDeviation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.6">
+                <Parameter id="bZuwrWRPck-EByIQtnLeIA" name="GeometricDeviation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.6">
                   <Info min="1" flag="18" seq="1" ref="0" bb="32" group="144" />
                 </Parameter>
               </Children>
               <Info min="0" flag="106" seq="1" ref="0" bb="32" group="144" />
             </DistributedParameter>
-            <Container id="2UkNT1GrSEGPAlaFowDKXA" name="Stomach" mode="Physical" containerType="Compartment">
+            <Container id="RsslivV9F0iNMAFK3ZSVfw" name="Stomach" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="Lumen" />
                 <Tag value="LumenSegment" />
               </Tags>
               <Children>
-                <Parameter id="l5-gIhrniE6ubACXF26zHw" name="Absorption of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0" displayUnit="1/min">
+                <Parameter id="phz47wQ5w02i-BERh6duFA" name="Absorption of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0" displayUnit="1/min">
                   <Info flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="D8pnW7mI40SdezCpLVJ-wg" name="FillLevelFlag" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevelFlagFlag" isDefault="1">
+                <Parameter id="Hd4LCcTmnku7NjtLSGTYtA" name="FillLevelFlag" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevelFlagFlag" isDefault="1">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="lX1lqfFVlUWO8hLCgm7l9w" name="Fraction of geometric volume filled with liquid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevel" isDefault="1">
+                <Parameter id="Rf6A5AaMNUa6AmW5UKp96Q" name="Fraction of geometric volume filled with liquid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevel" isDefault="1">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="zvcr8XKW00C77UfL4T1CBA" name="Geometric surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Area" isDefault="1" displayUnit="cm²">
+                <Parameter id="__ZCLtTbGEq-Q7yk5n0SNg" name="Geometric surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Area" isDefault="1" displayUnit="cm²">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info min="0" flag="62" seq="1" ref="0" bb="32" group="33" />
                 </Parameter>
-                <Parameter id="xeGwGW6k90uWeX79WcIQnQ" name="GET of non-disintegrated moiety" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="60" displayUnit="min">
+                <Parameter id="KpqYY33O10aw2KDhR5bIVQ" name="GET of non-disintegrated moiety" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="60" displayUnit="min">
                   <Info min="0" flag="122" seq="1" ref="0" bb="2" group="39" />
                 </Parameter>
-                <Parameter id="6_7-8qGCPU2pZifm89nSag" name="Intestinal transit rate (absolute)" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_InverseGastricEmptyingTime" isDefault="1" displayUnit="1/min">
+                <Parameter id="QhyfouBSCUKiWFWmO0yo3A" name="Intestinal transit rate (absolute)" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_InverseGastricEmptyingTime" isDefault="1" displayUnit="1/min">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="tik3J1329EieJJ4DurGxDg" name="Liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Liquid_StartValue" isDefault="1" rHSFormula="Lumen_PKSim.LiquidRHS_sto" displayUnit="l">
+                <Parameter id="96_1zdOe-UCsqaM7vUHSjw" name="Liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Liquid_StartValue" isDefault="1" rHSFormula="Lumen_PKSim.LiquidRHS_sto" displayUnit="l">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="f1yLt-1eAUu_DrCjcz4BOw" name="Liquid transfer rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_LiquidTransferRate_sto" isDefault="1" displayUnit="l/min">
+                <Parameter id="iXco_Or70k-sSCPJzMYaxQ" name="Liquid transfer rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_LiquidTransferRate_sto" isDefault="1" displayUnit="l/min">
                   <Info flag="52" seq="1" ref="0" bb="2" group="39" />
                 </Parameter>
-                <Parameter id="e671TvpsAUW29IbLwqHPPw" name="Secretion of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Inflow_Stomach" isDefault="1" displayUnit="l/min">
+                <Parameter id="ZDdAIALFR0S1vqs4_TqJ_w" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_pH_from_pH_fasted" isDefault="1">
+                  <Tags>
+                    <Tag value="Lumen" />
+                    <Tag value="LumenSegment" />
+                  </Tags>
+                  <Info min="0" max="14" flag="52" seq="1" ref="0" bb="32" group="41" />
+                </Parameter>
+                <Parameter id="_zOT8_PjU0yN9zvF7ubsAw" name="Secretion of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Inflow_Stomach" isDefault="1" displayUnit="l/min">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="EKa9UYQvnkS9qyv5OIDDHw" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_LumenSegment" isDefault="1" displayUnit="l">
+                <Parameter id="zvH2gUXL-0O453D-1BdPxA" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_LumenSegment" isDefault="1" displayUnit="l">
                   <Info min="0" flag="62" seq="1" ref="0" bb="2" group="56" />
                 </Parameter>
-                <Parameter id="PeelIFae_0qabaDW-LucLw" name="Volume (gut wall)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="MucosaVolume.PARAM_VolumeGutWall" isDefault="1" displayUnit="l">
+                <Parameter id="sdfhtZTUd0STBBQ_VZmPmw" name="Volume (gut wall)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="MucosaVolume.PARAM_VolumeGutWall" isDefault="1" displayUnit="l">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info min="0" flag="62" seq="1" ref="0" bb="32" group="44" />
                 </Parameter>
-                <Parameter id="3y8mNuYH6UKVSmf4vlpjlA" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                <Parameter id="PZRV-r5HREi14mVWw0fWQg" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
                   <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                 </Parameter>
-                <Parameter id="FcUPeC7FiEWjgTmePliavw" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_pH_from_pH_fasted" isDefault="1">
+                <Parameter id="ldl2CRjrNE2nqvANJRq04Q" name="Fractional steady state fill level" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.030169">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" max="14" flag="52" seq="1" ref="0" bb="32" group="41" />
+                  <Info min="0" flag="58" seq="1" ref="0" bb="32" group="43" />
                 </Parameter>
-                <Parameter id="ruhKzE4bAEeOsxZ_yx82AQ" name="Thickness of gut wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.022668" displayUnit="cm">
+                <Parameter id="gcsUslDKp06ciT27Iq9M6Q" name="pH in fed state" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="5.5">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="54" seq="1" ref="0" bb="32" group="45" />
+                  <Info min="0" max="14" flag="52" seq="1" ref="0" bb="32" group="41" />
                 </Parameter>
-                <Parameter id="yeLREw97xEucJ6VAzZ6i3Q" name="Fractional steady state fill level" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.030169">
+                <Parameter id="vo-H12RvMESfjRwhFnvaEg" name="Thickness of gut wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.022668" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="58" seq="1" ref="0" bb="32" group="43" />
+                  <Info min="0" flag="54" seq="1" ref="0" bb="32" group="45" />
                 </Parameter>
-                <Parameter id="_eAYLX6Fu0mPUWpZ3DIpMQ" name="pH in fed state" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="5.5">
+                <Parameter id="ronXVlMm40el-6yTe9RpnA" name="Inverse rate of inflow of liquid into stomach" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="15" displayUnit="min">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" max="14" flag="52" seq="1" ref="0" bb="32" group="41" />
+                  <Info min="1" max="10000" flag="54" seq="1" ref="0" bb="32" group="46" />
                 </Parameter>
-                <Parameter id="r4xm874UZk-kT3WrzmF5Lw" name="pH in fasted state" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2">
+                <Parameter id="nidpeeL4-EyD_dgi55xCeQ" name="pH in fasted state" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
@@ -3304,19 +3328,12 @@
                   <ValueOrigin id="25" source="Publication" description="Stefan Willmann, Walter Schmitt,Jörg Keldenich, Jörg Lippert, and Jennifer B. Dressman: A Physiological Model for the Estimation of the Fraction Dose Absorbed in Humans. J. Med. Chem. 2004, 47, 4022-4031" />
                   <Info min="0" max="14" flag="122" seq="1" ref="0" bb="32" group="41" />
                 </Parameter>
-                <Parameter id="4vBQoYaRP0mytmaN6jGP7w" name="Inverse rate of inflow of liquid into stomach" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="15" displayUnit="min">
-                  <Tags>
-                    <Tag value="Lumen" />
-                    <Tag value="LumenSegment" />
-                  </Tags>
-                  <Info min="1" max="10000" flag="54" seq="1" ref="0" bb="32" group="46" />
-                </Parameter>
-                <DistributedParameter id="uANqYBEeak6L6qImKHMDkQ" name="Distal radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="G9eK5tk5NEihgAUZdEuoFA" mode="Logical" isDefault="1" displayUnit="cm">
+                <DistributedParameter id="X_fQFWH4rUOzH2la6jAPrg" name="Distal radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="UKfL-5mpA0eI7p6w_Y2wQg" mode="Logical" isDefault="1" displayUnit="cm">
                   <Children>
-                    <Parameter id="IQeVO7aBJ0mFFqEdMtroGg" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5" displayUnit="cm">
+                    <Parameter id="FC0NsNUEmkejNYnvVtjFKw" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5" displayUnit="cm">
                       <Info min="0" flag="18" seq="1" ref="0" bb="32" group="35" />
                     </Parameter>
-                    <Parameter id="fB26oIQMDEit0AaimLECVA" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5" displayUnit="cm">
+                    <Parameter id="2NDyKxmFWkWEqHJYVE_XZg" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5" displayUnit="cm">
                       <Info min="0" flag="50" seq="1" ref="0" bb="32" group="35" />
                     </Parameter>
                   </Children>
@@ -3326,30 +3343,33 @@
                   </Tags>
                   <Info min="0" flag="122" seq="1" ref="0" bb="32" group="35" />
                 </DistributedParameter>
-                <DistributedParameter id="9XTbdmvPTkai8pNZSUpp4A" name="Length" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="mLZ5Sl-LKkOpZsbgy4oSZw" mode="Logical" isDefault="1" displayUnit="cm">
+                <DistributedParameter id="sFn-gRIedkCNqbmmwThDsg" name="Gastric emptying time" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="AxddRk-Z9E2XZcIgm_Q9UA" mode="Logical" isDefault="1" displayUnit="min">
                   <Children>
-                    <Parameter id="i7-2y7r7skySVUzILfyB0Q" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5" displayUnit="cm">
-                      <Info min="0" flag="18" seq="1" ref="0" bb="32" group="34" />
+                    <Parameter id="IF-I0OiruEy5hHS6k0EM0g" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5" displayUnit="min">
+                      <Info min="0" flag="18" seq="1" ref="0" bb="32" group="46" />
                     </Parameter>
-                    <Parameter id="UOqx-lEj8EqEu4dER5auRQ" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2" displayUnit="cm">
-                      <Info min="0" flag="50" seq="1" ref="0" bb="32" group="34" />
+                    <Parameter id="arUXVfg3HkCgSDwMr4-aFA" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="15" displayUnit="min">
+                      <Info min="1" max="10000" flag="50" seq="1" ref="0" bb="32" group="46" />
+                    </Parameter>
+                    <Parameter id="qm9WND9xJUq19mPP6_rK8A" name="GeometricDeviation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.6">
+                      <Info min="1" flag="18" seq="1" ref="0" bb="32" group="46" />
                     </Parameter>
                   </Children>
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="122" seq="1" ref="0" bb="32" group="34" />
+                  <Info min="1" max="10000" flag="122" seq="1" ref="0" bb="32" group="46" />
                 </DistributedParameter>
-                <DistributedParameter id="X5jbg-dpK0CD5debsWQU9g" name="GET_beta (Weibull function) variability factor" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="leok9Enjr0yl15glqzco_Q" mode="Logical" isDefault="1">
+                <DistributedParameter id="x4zB71ujTEWmqINVeZTPtw" name="GET_alpha (Weibull function) variability factor" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="c6Pz0rwVeUaM69_yHxI9JQ" mode="Logical" isDefault="1">
                   <Children>
-                    <Parameter id="uieVZQN-tUaRHJm7GhlpLg" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                    <Parameter id="rtBOsdmYGkeKyjDhUZsjcw" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
                       <Info min="0" flag="18" seq="1" ref="0" bb="32" group="46" />
                     </Parameter>
-                    <Parameter id="MYpTrF-buUi0LZ2ClUPbSg" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                    <Parameter id="d7Wd5RJtVUq09I73LEPXPg" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
                       <Info min="0" flag="34" seq="1" ref="0" bb="32" group="46" />
                     </Parameter>
-                    <Parameter id="OAloaRaLTkeCPeLDnQ7jFg" name="GeometricDeviation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.32">
+                    <Parameter id="9usgGXiq2UGyvOga1vybAw" name="GeometricDeviation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.74">
                       <Info min="1" flag="18" seq="1" ref="0" bb="32" group="46" />
                     </Parameter>
                   </Children>
@@ -3359,15 +3379,15 @@
                   </Tags>
                   <Info min="0" flag="38" seq="1" ref="0" bb="32" group="46" />
                 </DistributedParameter>
-                <DistributedParameter id="U2P-JGOOxUG8lVxlmIKCXg" name="Gastric emptying time" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="xbQemODQekaI8OlYRyXUKw" mode="Logical" isDefault="1" displayUnit="min">
+                <DistributedParameter id="LHE69HSb3EaoVI2mFvyy8Q" name="GET_beta (Weibull function) variability factor" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IY75dyKQtkufwKnOr1QulA" mode="Logical" isDefault="1">
                   <Children>
-                    <Parameter id="4KkIz42vjU2NZXLGgII3RQ" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5" displayUnit="min">
+                    <Parameter id="jT8yANIJI0e1TgCWEClCOQ" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
                       <Info min="0" flag="18" seq="1" ref="0" bb="32" group="46" />
                     </Parameter>
-                    <Parameter id="RuMhV6SCh0aECkbm6AHPlA" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="15" displayUnit="min">
-                      <Info min="1" max="10000" flag="50" seq="1" ref="0" bb="32" group="46" />
+                    <Parameter id="6DxfHXR4p0K0ysugy3czuw" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                      <Info min="0" flag="34" seq="1" ref="0" bb="32" group="46" />
                     </Parameter>
-                    <Parameter id="8x-70ooVV0uoPNLD1dXizw" name="GeometricDeviation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.6">
+                    <Parameter id="QPngBPXLX06VkVSVzF7GCw" name="GeometricDeviation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.32">
                       <Info min="1" flag="18" seq="1" ref="0" bb="32" group="46" />
                     </Parameter>
                   </Children>
@@ -3375,32 +3395,29 @@
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="1" max="10000" flag="122" seq="1" ref="0" bb="32" group="46" />
+                  <Info min="0" flag="38" seq="1" ref="0" bb="32" group="46" />
                 </DistributedParameter>
-                <DistributedParameter id="Y1jGErd_gECZdJDjQE1L7Q" name="GET_alpha (Weibull function) variability factor" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="GYxKH74tmkCqkdtYjKUZMA" mode="Logical" isDefault="1">
+                <DistributedParameter id="KuxY61dmdUiMaF1LJMTxoQ" name="Length" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="vIrkfgsjRUyv9e3NcTPl8w" mode="Logical" isDefault="1" displayUnit="cm">
                   <Children>
-                    <Parameter id="JA32XzFbJUqkPiIXi9EC7w" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
-                      <Info min="0" flag="18" seq="1" ref="0" bb="32" group="46" />
-                    </Parameter>
-                    <Parameter id="rOK1m-aKpUO16ovkt76PFg" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
-                      <Info min="0" flag="34" seq="1" ref="0" bb="32" group="46" />
+                    <Parameter id="VM75mcJNV0aICp4eq70DmQ" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5" displayUnit="cm">
+                      <Info min="0" flag="18" seq="1" ref="0" bb="32" group="34" />
                     </Parameter>
-                    <Parameter id="4o3fRWCR4kCylBOQe4ao9w" name="GeometricDeviation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.74">
-                      <Info min="1" flag="18" seq="1" ref="0" bb="32" group="46" />
+                    <Parameter id="5uxcHfQky0W1IMiiwDw6Tg" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2" displayUnit="cm">
+                      <Info min="0" flag="50" seq="1" ref="0" bb="32" group="34" />
                     </Parameter>
                   </Children>
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="38" seq="1" ref="0" bb="32" group="46" />
+                  <Info min="0" flag="122" seq="1" ref="0" bb="32" group="34" />
                 </DistributedParameter>
-                <DistributedParameter id="KcNilccOIkGe0eoeo0i52w" name="Proximal radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="1GKeCEgEbUW2wWI0vVV4yw" mode="Logical" isDefault="1" displayUnit="cm">
+                <DistributedParameter id="7X4fe9XRB0GJ7sV9rmbROA" name="Proximal radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="RiWtibycR0eANq0enNQMug" mode="Logical" isDefault="1" displayUnit="cm">
                   <Children>
-                    <Parameter id="SHQalOtdjUOga2vpzEWZkQ" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5" displayUnit="cm">
+                    <Parameter id="LFOl3TZZGE6IUzZj_rnwEg" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5" displayUnit="cm">
                       <Info min="0" flag="18" seq="1" ref="0" bb="32" group="35" />
                     </Parameter>
-                    <Parameter id="8CBgwpvENkSBir6SCqVaNw" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5" displayUnit="cm">
+                    <Parameter id="IfRz2GXY5EuMn5lCN45hGg" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5" displayUnit="cm">
                       <Info min="0" flag="50" seq="1" ref="0" bb="32" group="35" />
                     </Parameter>
                   </Children>
@@ -3410,231 +3427,234 @@
                   </Tags>
                   <Info min="0" flag="122" seq="1" ref="0" bb="32" group="35" />
                 </DistributedParameter>
-                <Container id="i1WFjGZO-EGr_Z54FDg2Hw" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="C-f2TANun0GniELl_dRFiw" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                   <Children>
-                    <Parameter id="9tvb3bNjakePv_pzQfpWyQ" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" isDefault="1">
-                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
-                    </Parameter>
-                    <Parameter id="Kme6s0rsPk-NwtuvwL4KwA" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal_GI" isDefault="1">
+                    <Parameter id="EAAMkxZwp02QJYQ0TVUNPA" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal_GI" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                     </Parameter>
-                    <Parameter id="sNo9QqA2i02tksAwNTfXEw" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" isDefault="1">
+                    <Parameter id="BPChJxl1MUKRyE4TyzJiIw" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                    </Parameter>
+                    <Parameter id="Y7Tcb1Aj9UKYu51o7Cet5g" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                    </Parameter>
+                    <Parameter id="_UxAp_fRyUm4bp_QDyqJeg" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="my1vA6QLbEKxd96ayoqBaA" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" isDefault="1">
+                    <Parameter id="Wy2DzqS-gUew_5pB3n3y-w" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="oK2mwJcV9EWrAbf81nwtmQ" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" isDefault="1">
+                    <Parameter id="bmeRTlBE3UeJyotgF6a9xw" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="upocYg5mEUOWD_fXZFM_mQ" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" isDefault="1">
+                    <Parameter id="91e66T79M0unTPB7PkVTJg" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="TRJ-U7zSHEK4JzvHpaGWrg" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" isDefault="1">
+                    <Parameter id="njMr2hNfGk2YkWyCEKLKlQ" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="IsRnhos6N0yclvCDc9GfJw" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" isDefault="1">
+                    <Parameter id="5fX881ngoE-JquqPN0sKwQ" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="zpTi4v6oy0-r8xO-OqaiOA" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" isDefault="1">
+                    <Parameter id="oKCA24aiNEysH18dVvQo9Q" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="g160h6eeYUaGY3oVybQxuA" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" isDefault="1">
+                    <Parameter id="0Qwp_w5j2EebnMJE3TVRVg" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="hRkJtkirz06iMcL-y2ZAVQ" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" isDefault="1">
+                    <Parameter id="4blfFAXsyEyoQWstnvuWNw" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="7ZtwsaXzU0eY4uuJs8KwcQ" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" isDefault="1">
+                    <Parameter id="JoTR1pq-b0-1wZroCjqpHA" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="7CwCBriJY0q8AvTXVHB8kw" name="Solubility" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_IntestinalSolubility" isDefault="1" displayUnit="mg/l">
+                    <Parameter id="OINao1eF8kaO4FqoJ58YHA" name="Solubility" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_IntestinalSolubility" isDefault="1" displayUnit="mg/l">
                       <Info min="0" flag="122" seq="1" ref="0" bb="2" group="42" />
                     </Parameter>
-                    <Parameter id="SzAihtr6FUG-Ppt0alMDMQ" name="Solubility table" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.TableFormulaWithXArgument_SolubilityTable" isDefault="1" displayUnit="mg/l">
+                    <Parameter id="lldR6UL3kUKh-x2tIDrX6g" name="Solubility table" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.TableFormulaWithXArgument_SolubilityTable" isDefault="1" displayUnit="mg/l">
                       <Info min="0" flag="50" seq="1" ref="0" bb="2" group="42" />
                     </Parameter>
-                    <Parameter id="NmVqMCSoPEOO0fwYRMPgpQ" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
-                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
-                    </Parameter>
-                    <Parameter id="C-ctT2j3lUa4dPpOYH5GkQ" name="Solubility_pKa_pH_Factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" isDefault="1">
+                    <Parameter id="COUeMdzmzky_bPjQV-KJJg" name="Solubility_pKa_pH_Factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="eE3EyQ011ECj-6mI--BwNA" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                    <Parameter id="dRLuuXsNvk-m-0FxhWd8ag" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
                       <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                     </Parameter>
+                    <Parameter id="DbfCVGze5U2AvYTnpPV1gg" name="Effective concentration in lumen" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_EffectiveLumenConcentration" isDefault="1" displayUnit="µmol/l">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="42" />
+                    </Parameter>
                   </Children>
                 </Container>
               </Children>
             </Container>
-            <Container id="R6oHTJqg9kGzj5KJS4zGGg" name="Duodenum" mode="Physical" containerType="Compartment">
+            <Container id="1WeVhpyE0E2FsX9S1BNctw" name="Duodenum" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="Lumen" />
                 <Tag value="LumenSegment" />
               </Tags>
               <Children>
-                <Parameter id="jHp3TbOW3kipfkgRBKJ1Vg" name="Intestinal transit rate (absolute)" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_InverseSITT_Factor_Duodenum" isDefault="1" displayUnit="1/min">
-                  <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                <Parameter id="N6KLHpzVK0-UGdFim0iXXA" name="Absorption of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Outflow_Duodenum" isDefault="1" displayUnit="1/min">
+                  <Info flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="lH9w7r2dukqDgsG7YJkMHw" name="Length" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Length" isDefault="1" displayUnit="cm">
+                <Parameter id="ygdmoex5tEm--V7jOXv6Zw" name="Distal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R2" isDefault="1" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="106" seq="1" ref="0" bb="32" group="34" />
-                </Parameter>
-                <Parameter id="zQl8NrPXgECg03i4y8UNXg" name="Liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Liquid_StartValue" isDefault="1" rHSFormula="Lumen_PKSim.LiquidRHS_duo" displayUnit="l">
-                  <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
-                </Parameter>
-                <Parameter id="EeyhOrStlESc5LqAQ1twiQ" name="Liquid transfer rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_LiquidTransferRate_duo" isDefault="1" displayUnit="l/min">
-                  <Info flag="52" seq="1" ref="0" bb="2" group="39" />
+                  <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="zhujuTNEo0KRrPsDG06yEA" name="Proximal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R1" isDefault="1" displayUnit="cm">
+                <Parameter id="5_A1iGKrEEO5fc3_7KH8gQ" name="Effective surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_EffectiveSurfaceArea" isDefault="1" displayUnit="cm²">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
+                  <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
+                  <Info min="0" flag="52" seq="1" ref="0" bb="32" group="33" />
+                </Parameter>
+                <Parameter id="bvVwxo9sXUGZyr_KXaIzZA" name="FillLevelFlag" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevelFlagFlag" isDefault="1">
+                  <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="Hei_0GueIkCPH4BmUwoqrQ" name="Secretion of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Inflow_Duodenum" isDefault="1" displayUnit="l/min">
+                <Parameter id="WVgKCejlvUigFRwfRbfK9w" name="Fraction of geometric volume filled with liquid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevel" isDefault="1">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="lDXbX7Q-u06Y33A4Iqn6fQ" name="Thickness of gut wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Thickness" isDefault="1" displayUnit="cm">
+                <Parameter id="IOCE-GXiDkWhFYSJe7RyWA" name="Geometric surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Area" isDefault="1" displayUnit="cm²">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="38" seq="1" ref="0" bb="32" group="45" />
-                </Parameter>
-                <Parameter id="l-c4saAGnUeiZZeu9tUdtg" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_LumenSegment" isDefault="1" displayUnit="l">
-                  <Info min="0" flag="62" seq="1" ref="0" bb="2" group="56" />
+                  <Info min="0" flag="62" seq="1" ref="0" bb="32" group="33" />
                 </Parameter>
-                <Parameter id="DjoWzjYxykSdm9dBdqUrBA" name="FillLevelFlag" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevelFlagFlag" isDefault="1">
+                <Parameter id="ykuYp1vcU0CqYcbx47S_QQ" name="Intestinal transit rate (absolute)" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_InverseSITT_Factor_Duodenum" isDefault="1" displayUnit="1/min">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="yQGKMcem8k6xRrCnZuaupA" name="Volume (gut wall)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="MucosaVolume_Human.PARAM_VolumeGutWall_Duodenum" isDefault="1" displayUnit="l">
+                <Parameter id="q1Wmnil2S02FCjVM996scg" name="Length" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Length" isDefault="1" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="62" seq="1" ref="0" bb="32" group="44" />
+                  <Info min="0" flag="106" seq="1" ref="0" bb="32" group="34" />
                 </Parameter>
-                <Parameter id="NF9a_gXs00qzV8SQvgXwlA" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
-                  <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                <Parameter id="xqOwAsOApkG7fmtwu4wcxA" name="Liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Liquid_StartValue" isDefault="1" rHSFormula="Lumen_PKSim.LiquidRHS_duo" displayUnit="l">
+                  <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                </Parameter>
+                <Parameter id="R5Y-fin2TEObXduehawLWg" name="Liquid transfer rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_LiquidTransferRate_duo" isDefault="1" displayUnit="l/min">
+                  <Info flag="52" seq="1" ref="0" bb="2" group="39" />
                 </Parameter>
-                <Parameter id="XZ4qN9pOoUC8Q_3plni09g" name="Geometric surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Area" isDefault="1" displayUnit="cm²">
+                <Parameter id="FL8bapGKzUeQa67d2mvKxA" name="Proximal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R1" isDefault="1" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="62" seq="1" ref="0" bb="32" group="33" />
+                  <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="IQugN-6iq0KXch1tXCJY3w" name="Fraction of geometric volume filled with liquid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevel" isDefault="1">
+                <Parameter id="hOd4pzn7_0WEI9XDanyiCg" name="Secretion of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Inflow_Duodenum" isDefault="1" displayUnit="l/min">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="VBudElXU606ASqcURHOxuA" name="Absorption of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Outflow_Duodenum" isDefault="1" displayUnit="1/min">
-                  <Info flag="54" seq="1" ref="0" bb="2" group="63" />
-                </Parameter>
-                <Parameter id="CivTDxG9KE2swXc_3eMQ9g" name="Distal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R2" isDefault="1" displayUnit="cm">
+                <Parameter id="rOTc5tNIDEmpQWQ9vvy-Uw" name="Thickness of gut wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Thickness" isDefault="1" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
+                  <Info min="0" flag="38" seq="1" ref="0" bb="32" group="45" />
+                </Parameter>
+                <Parameter id="uuOhbc2PyUCSGJGosNJ-1A" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_LumenSegment" isDefault="1" displayUnit="l">
+                  <Info min="0" flag="62" seq="1" ref="0" bb="2" group="56" />
                 </Parameter>
-                <Parameter id="ycA0anZhjke2yUT_ks_4tQ" name="Effective surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_EffectiveSurfaceArea" isDefault="1" displayUnit="cm²">
+                <Parameter id="Lqu7A6Mlp0SPJOfwuV9H_A" name="Volume (gut wall)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="MucosaVolume_Human.PARAM_VolumeGutWall_Duodenum" isDefault="1" displayUnit="l">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
-                  <Info min="0" flag="52" seq="1" ref="0" bb="32" group="33" />
+                  <Info min="0" flag="62" seq="1" ref="0" bb="32" group="44" />
+                </Parameter>
+                <Parameter id="UTzqYJSuQU2a79IRRr2XPg" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                  <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                 </Parameter>
-                <Parameter id="5vaZrP7WYECMPjbsL0VtCg" name="Microvilli factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="25">
+                <Parameter id="DMXfxPehH0uIm18cZ5eInw" name="Fractional steady state fill level" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.06">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="38" seq="1" ref="0" bb="32" group="33" />
+                  <Info min="0" flag="58" seq="1" ref="0" bb="32" group="43" />
                 </Parameter>
-                <Parameter id="8XZ7sJktw0uxeH86FdnY7A" name="L_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0289872252" displayUnit="cm">
+                <Parameter id="pAVbBRi0KUGz6uZ01DA0RQ" name="Intestinal transit rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="116" displayUnit="1/min">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="34" />
+                  <Info min="0" flag="54" seq="1" ref="0" bb="32" group="46" />
                 </Parameter>
-                <Parameter id="-qwvJOpdVUeuNOB1TF5BGA" name="Intestinal transit rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="116" displayUnit="1/min">
+                <Parameter id="01jT58ESbEGRByJCvRuGkw" name="L_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0289872252" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="54" seq="1" ref="0" bb="32" group="46" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="34" />
                 </Parameter>
-                <Parameter id="bRSAwpnjt0WrD8n00kKc4g" name="Fractional steady state fill level" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.06">
+                <Parameter id="DoQtve0cfkyMxQyLIQsRYg" name="L_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.129622362">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="58" seq="1" ref="0" bb="32" group="43" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="34" />
                 </Parameter>
-                <Parameter id="THTgAtnc5Eq6MVXXBpGSUg" name="r1_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.002264627" displayUnit="cm">
+                <Parameter id="tgZ-zJ4uBU2K03W87zHa1A" name="Microvilli factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="25">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                  <Info min="0" flag="38" seq="1" ref="0" bb="32" group="33" />
                 </Parameter>
-                <Parameter id="DWzlB0lmkk2N-L1oHd-QOw" name="L_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.129622362">
+                <Parameter id="YiBUIVqxV0KAMK6WNu1zxQ" name="r1_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.002264627" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="34" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="1aodwN74DUuxDSZkBXi7QQ" name="Thickness_p3" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.30705627" displayUnit="1/cm">
+                <Parameter id="G56UAEVrbkyhWb_vwSZLuA" name="r1_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.010126747">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="dTcTlxFGM0SqhZ6oOpb4aw" name="Thickness_p2" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0441002752" displayUnit="cm">
+                <Parameter id="oW3QMpQB9EWtcz3q_rzoYw" name="r2_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0020705161" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="MqLKbdnVTUSZYf-LpUIngg" name="Thickness_p1" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0186500479" displayUnit="cm">
+                <Parameter id="mcOOWmZcHUq636BL_14EYA" name="r2_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.00925874">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="1kHv6u81EEKIbvuTRL3u3g" name="r2_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.00925874">
+                <Parameter id="tRUuHYwD9Eas5-LBupTryA" name="Thickness_p1" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0186500479" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
                 </Parameter>
-                <Parameter id="JWxaWg-7IUuSnlM2f8P9ow" name="r2_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0020705161" displayUnit="cm">
+                <Parameter id="F4epK0ZQvEa1V3RcfEx2qQ" name="Thickness_p2" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0441002752" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
                 </Parameter>
-                <Parameter id="79nGeOKJoE64b29FWt_ZGw" name="r1_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.010126747">
+                <Parameter id="uPCLaw2_9UCByDAl66lXPw" name="Thickness_p3" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.30705627" displayUnit="1/cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
                 </Parameter>
-                <Parameter id="Fgw92iMEe0S89l2NLfe9xw" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="6">
+                <Parameter id="RorUS8yYgUqFH9EKzD6H1Q" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="6">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
@@ -3642,12 +3662,12 @@
                   <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
                   <Info min="0" max="14" flag="122" seq="1" ref="0" bb="32" group="41" />
                 </Parameter>
-                <DistributedParameter id="p_sqhHZ8rkK3BlNUxFrB2w" name="Effective surface area enhancement factor" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="cuK2Ask29U-i86sI6Qd0-g" mode="Logical" isDefault="1">
+                <DistributedParameter id="_NddACiQREeNhTuerzaQ7Q" name="Effective surface area enhancement factor" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="7HdqW1Kvfku7xXN5TyOVwg" mode="Logical" isDefault="1">
                   <Children>
-                    <Parameter id="j-4FETLXP0-mjx0QRXo_Qw" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                    <Parameter id="PD9kEt7AFkmjaPmzYokOKw" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
                       <Info min="0" flag="18" seq="1" ref="0" bb="32" group="32" />
                     </Parameter>
-                    <Parameter id="qU-Tf3aaKk2F0u7eBN7clg" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="292.6883">
+                    <Parameter id="sFyJMfereU6jeHx6ktQMRg" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="292.6883">
                       <Info min="0" flag="50" seq="1" ref="0" bb="32" group="32" />
                     </Parameter>
                   </Children>
@@ -3657,234 +3677,237 @@
                   </Tags>
                   <Info min="0" flag="122" seq="1" ref="0" bb="32" group="32" />
                 </DistributedParameter>
-                <Container id="tkA5HaCOCUy1CbWQxfA9Lg" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="LuJ8KTbDIU-nLE-KSKFFkA" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                   <Children>
-                    <Parameter id="5fvurgNcJ0S2vbxzLhNZJw" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" isDefault="1">
-                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
-                    </Parameter>
-                    <Parameter id="MtoH5diRHkGjqrFg1fEy8A" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal_GI" isDefault="1">
+                    <Parameter id="yn2nocNk8kSzCn13Y8Qb1g" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal_GI" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                     </Parameter>
-                    <Parameter id="kEMtGzummkyrNa8CteIfCQ" name="Oral mass absorbed segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" rHSFormula="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_duo" value="0" displayUnit="µmol">
+                    <Parameter id="ZEdc8okmD06ZTN5bMwr-NQ" name="Oral mass absorbed segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" rHSFormula="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_duo" value="0" displayUnit="µmol">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                     </Parameter>
-                    <Parameter id="Kqv4nHNM1ku94Vo5lCUhtA" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" isDefault="1">
+                    <Parameter id="PSD1Gdeln0G-njvCLSueuQ" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                    </Parameter>
+                    <Parameter id="nzfhhlgkDkSNFRfgEGTWGQ" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="edA5Xk3Cx02jVQo4FXIJug" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" isDefault="1">
+                    <Parameter id="i3C0bJU7Z0WMgRnedzNgwA" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="FOKepoAsU0-2naHikSLoKA" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" isDefault="1">
+                    <Parameter id="oBurpQzjAEiFNPuLUjOBeA" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="-m2hbDpaFUy2kQF-h5rLCw" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" isDefault="1">
+                    <Parameter id="t9qYZECwBEuSB2Q4kKjDYg" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="YtIrp6dl6ECq7h81n7_A1Q" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" isDefault="1">
+                    <Parameter id="hVKnKmdMZkW-VXPSo7XafA" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="CFkEvRJF_kiOrmgPY1djKA" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" isDefault="1">
+                    <Parameter id="RTRP20HAOUmxrA852XY9fw" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="wEyvAo1AH0yP6HvuZq1D_A" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" isDefault="1">
+                    <Parameter id="XpHatZot-k2-QKIziyWOIQ" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="fsNpjpiiaUSCyvegK4FEbg" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" isDefault="1">
+                    <Parameter id="M52qsWBlsUGQsYCcrYTH3A" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="CxY2iLeqJkO1jkIV20IeLQ" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" isDefault="1">
+                    <Parameter id="JCv4MCIhDE6ryxzi4cBCBw" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="FksXslJrdUu6q5mVrsjL6w" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" isDefault="1">
+                    <Parameter id="piEW5qiig0ur_VxU_0tJ-Q" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="98nfEp2yzEaS2SSoTh6TbA" name="Solubility" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_IntestinalSolubility" isDefault="1" displayUnit="mg/l">
+                    <Parameter id="KY9Tdw-dBUGX4EQXfgWFEA" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                    </Parameter>
+                    <Parameter id="ZsOuhwksSUu5_FahTWbpQg" name="Solubility" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_IntestinalSolubility" isDefault="1" displayUnit="mg/l">
                       <Info min="0" flag="122" seq="1" ref="0" bb="2" group="42" />
                     </Parameter>
-                    <Parameter id="kWB3UnLf7EWRpqxTho1YBQ" name="Solubility table" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.TableFormulaWithXArgument_SolubilityTable" isDefault="1" displayUnit="mg/l">
+                    <Parameter id="0VLYCVLVd0-3xfCyDD8low" name="Solubility table" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.TableFormulaWithXArgument_SolubilityTable" isDefault="1" displayUnit="mg/l">
                       <Info min="0" flag="50" seq="1" ref="0" bb="2" group="42" />
                     </Parameter>
-                    <Parameter id="Wtvf778PcEy2_65HUj3pRw" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
-                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
-                    </Parameter>
-                    <Parameter id="yrI8rC_VIE62pe79L9WOrA" name="Solubility_pKa_pH_Factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" isDefault="1">
+                    <Parameter id="xg8JJLRoCU-gOj6VriWF9w" name="Solubility_pKa_pH_Factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="d5W6-kEQSUiw9HnT-XGwVg" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                    <Parameter id="6HhlmTZqakevB7jarOE0uw" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
                       <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                     </Parameter>
+                    <Parameter id="qKb9sxyCwkeSEUzpOSyBfg" name="Effective concentration in lumen" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_EffectiveLumenConcentration" isDefault="1" displayUnit="µmol/l">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="42" />
+                    </Parameter>
                   </Children>
                 </Container>
               </Children>
             </Container>
-            <Container id="_WvzIfMtH0mN7r4XQbGfAg" name="UpperJejunum" mode="Physical" containerType="Compartment">
+            <Container id="nG2AxthZukKU2Jjz7hjFcQ" name="UpperJejunum" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="Lumen" />
                 <Tag value="LumenSegment" />
               </Tags>
               <Children>
-                <Parameter id="CIMio4cj8EaDrlMbg4mUuQ" name="Intestinal transit rate (absolute)" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_InverseSITT_Factor_UpperJejunum" isDefault="1" displayUnit="1/min">
-                  <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                <Parameter id="RI4g7jnOxUyI_vctOh4x2A" name="Absorption of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Outflow_UpperJejunum" isDefault="1" displayUnit="1/min">
+                  <Info flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="MlgbNMZro0aBvfkhugdz6A" name="Volume (gut wall)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="MucosaVolume_Human.PARAM_VolumeGutWall_UpperJejunum" isDefault="1" displayUnit="l">
+                <Parameter id="-QW1WL8vYEGsikQN97SKHA" name="Distal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R2" isDefault="1" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="62" seq="1" ref="0" bb="32" group="44" />
-                </Parameter>
-                <Parameter id="9G3ejZGBt0CMwBvR6aT22g" name="Liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Liquid_StartValue" isDefault="1" rHSFormula="Lumen_PKSim.LiquidRHS_uje" displayUnit="l">
-                  <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
-                </Parameter>
-                <Parameter id="fbpS_0XKMUitiksGLnCr4g" name="Liquid transfer rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_LiquidTransferRate_uje" isDefault="1" displayUnit="l/min">
-                  <Info flag="52" seq="1" ref="0" bb="2" group="39" />
+                  <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="WpiAwobaG0izMlhU_62G0Q" name="Proximal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R1" isDefault="1" displayUnit="cm">
+                <Parameter id="Nuv49G9vnkWkabpohG1tQw" name="Effective surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_EffectiveSurfaceArea" isDefault="1" displayUnit="cm²">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
+                  <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
+                  <Info min="0" flag="52" seq="1" ref="0" bb="32" group="33" />
                 </Parameter>
-                <Parameter id="OlpNG6Arr0mlOFV73Q4Ipw" name="Secretion of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Inflow_UpperJejunum" isDefault="1" displayUnit="l/min">
+                <Parameter id="KTe-NkJQ7kmRLXN54qrXWw" name="FillLevelFlag" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevelFlagFlag" isDefault="1">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="76GXi1Huk0SrfRydtlYsiw" name="Thickness of gut wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Thickness" isDefault="1" displayUnit="cm">
+                <Parameter id="JXj8vnWx1U2E6BjWaqU5YA" name="Fraction of geometric volume filled with liquid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevel" isDefault="1">
+                  <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                </Parameter>
+                <Parameter id="ru0RNNzP5Um2yvMpDqU7bg" name="Geometric surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Area" isDefault="1" displayUnit="cm²">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="38" seq="1" ref="0" bb="32" group="45" />
-                </Parameter>
-                <Parameter id="kX5YDynUGUGS0KZ91UYCzQ" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_LumenSegment" isDefault="1" displayUnit="l">
-                  <Info min="0" flag="62" seq="1" ref="0" bb="2" group="56" />
+                  <Info min="0" flag="62" seq="1" ref="0" bb="32" group="33" />
                 </Parameter>
-                <Parameter id="f1otVuKjf0eNRTdXpudf4w" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
-                  <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                <Parameter id="EskjGumkQU6QbwAGZZ4nDA" name="Intestinal transit rate (absolute)" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_InverseSITT_Factor_UpperJejunum" isDefault="1" displayUnit="1/min">
+                  <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="XeVI-Ju2akuC8mNP0Y_qKQ" name="Geometric surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Area" isDefault="1" displayUnit="cm²">
+                <Parameter id="AGiOsaRjO0G9SMwJZKab2w" name="Length" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Length" isDefault="1" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="62" seq="1" ref="0" bb="32" group="33" />
+                  <Info min="0" flag="106" seq="1" ref="0" bb="32" group="34" />
+                </Parameter>
+                <Parameter id="aSlWXywrokaDY-QYzvqrrA" name="Liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Liquid_StartValue" isDefault="1" rHSFormula="Lumen_PKSim.LiquidRHS_uje" displayUnit="l">
+                  <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="7nAR8t-0aEK3kT0Cm4Y4pQ" name="Length" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Length" isDefault="1" displayUnit="cm">
+                <Parameter id="gY_BiP2Dhk-edXBZWk-ydA" name="Liquid transfer rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_LiquidTransferRate_uje" isDefault="1" displayUnit="l/min">
+                  <Info flag="52" seq="1" ref="0" bb="2" group="39" />
+                </Parameter>
+                <Parameter id="xPGFlBb_wE67t4C6Yq6Vxg" name="Proximal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R1" isDefault="1" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="106" seq="1" ref="0" bb="32" group="34" />
+                  <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="BPKi6bYYvkGVK-BZLV1eJA" name="Absorption of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Outflow_UpperJejunum" isDefault="1" displayUnit="1/min">
-                  <Info flag="54" seq="1" ref="0" bb="2" group="63" />
+                <Parameter id="qtv8KwbsG0GndzP6rseZaA" name="Secretion of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Inflow_UpperJejunum" isDefault="1" displayUnit="l/min">
+                  <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="LVXhD6aSE0m-kPU7hrw9Vw" name="Distal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R2" isDefault="1" displayUnit="cm">
+                <Parameter id="8LzcJNg-a0WCJsURuk1YVA" name="Thickness of gut wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Thickness" isDefault="1" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
+                  <Info min="0" flag="38" seq="1" ref="0" bb="32" group="45" />
                 </Parameter>
-                <Parameter id="Qcd4tNm5tE2MUt3WBIF6og" name="Effective surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_EffectiveSurfaceArea" isDefault="1" displayUnit="cm²">
+                <Parameter id="p-AsQCaIbkKGWrH2_G8mSQ" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_LumenSegment" isDefault="1" displayUnit="l">
+                  <Info min="0" flag="62" seq="1" ref="0" bb="2" group="56" />
+                </Parameter>
+                <Parameter id="wi6_8Dg9zEmxGLlyn3ggBw" name="Volume (gut wall)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="MucosaVolume_Human.PARAM_VolumeGutWall_UpperJejunum" isDefault="1" displayUnit="l">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
-                  <Info min="0" flag="52" seq="1" ref="0" bb="32" group="33" />
-                </Parameter>
-                <Parameter id="IcwTXraMlkG5Q6S2L48_xQ" name="FillLevelFlag" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevelFlagFlag" isDefault="1">
-                  <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                  <Info min="0" flag="62" seq="1" ref="0" bb="32" group="44" />
                 </Parameter>
-                <Parameter id="ocbev904KUaoxZ-MlC2HJg" name="Fraction of geometric volume filled with liquid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevel" isDefault="1">
-                  <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                <Parameter id="QCRx-dQRkEyHVOlYPNZU6g" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                  <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                 </Parameter>
-                <Parameter id="gRW16iqgKU238R-Q7i6JKg" name="r1_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.00925874">
+                <Parameter id="7CUOFA6h_E-aQ6YYAfgvOw" name="Fractional steady state fill level" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.064841">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                  <Info min="0" flag="58" seq="1" ref="0" bb="32" group="43" />
                 </Parameter>
-                <Parameter id="AdzA4ONVM0SO7dMaM5VD-A" name="r1_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0020705161" displayUnit="cm">
+                <Parameter id="qTjL2auFs0yCNgmxjQMocA" name="Intestinal transit rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="5.0162" displayUnit="1/min">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                  <Info min="0" flag="54" seq="1" ref="0" bb="32" group="46" />
                 </Parameter>
-                <Parameter id="-59W7b0eVUiX3ro37aOVtg" name="Microvilli factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="25">
+                <Parameter id="HtKczBEKxU6zBjnnMYWRMw" name="L_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0670329582" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="38" seq="1" ref="0" bb="32" group="33" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="34" />
                 </Parameter>
-                <Parameter id="fxE1lZ1T6UGNMhsoGSRI5A" name="L_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.299751712">
+                <Parameter id="i0e7gd7g_U68OwcCZ5QgCA" name="L_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.299751712">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info flag="54" seq="1" ref="0" bb="32" group="34" />
                 </Parameter>
-                <Parameter id="2TrshzJd0UKrvQgCNUk4kQ" name="L_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0670329582" displayUnit="cm">
+                <Parameter id="UpoRt83ot0W2xs7wEaPxKQ" name="Microvilli factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="25">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="34" />
+                  <Info min="0" flag="38" seq="1" ref="0" bb="32" group="33" />
                 </Parameter>
-                <Parameter id="Oveqt17-Xkax_XPABIY2Ww" name="r2_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.008680069">
+                <Parameter id="moQ_xMNWa0-PLHsH6ePgCQ" name="r1_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0020705161" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="3cP7Px_3k0q27gZOV-qyjA" name="Fractional steady state fill level" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.064841">
+                <Parameter id="hZl3cCNMq0qd-lSq9Rwp5g" name="r1_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.00925874">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="58" seq="1" ref="0" bb="32" group="43" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="i3QmJXBpjkCAm3Sqlcw-Tw" name="Thickness_p1" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.024936327" displayUnit="cm">
+                <Parameter id="HiDiMZNixUax9rQjL51NqQ" name="r2_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0019411088" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="kBXeCl88GE2KpSkG6Lq8Og" name="Intestinal transit rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="5.0162" displayUnit="1/min">
+                <Parameter id="cSA5nHJO20CyriPhVj9kuA" name="r2_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.008680069">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="54" seq="1" ref="0" bb="32" group="46" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="ajvq2qFUGkC_3eHl9ZRROw" name="r2_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0019411088" displayUnit="cm">
+                <Parameter id="H83f02rWDUGoZVgBi1pilw" name="Thickness_p1" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.024936327" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
                 </Parameter>
-                <Parameter id="cFloQwkH_0uBbBFal9Mtlg" name="Thickness_p3" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.30703115" displayUnit="1/cm">
+                <Parameter id="SRnk_CTWMkux2qWook2pmw" name="Thickness_p2" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0589752766" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info flag="54" seq="1" ref="0" bb="32" group="45" />
                 </Parameter>
-                <Parameter id="ZiQb4pf_XkmN6BQjBlJIqQ" name="Thickness_p2" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0589752766" displayUnit="cm">
+                <Parameter id="r1s7_k8KM0erm22Cj73rIg" name="Thickness_p3" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.30703115" displayUnit="1/cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info flag="54" seq="1" ref="0" bb="32" group="45" />
                 </Parameter>
-                <Parameter id="ctX6R3mxjECBDCb-G4XW4Q" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="6.25">
+                <Parameter id="9OP5XUS_MUG05e_p_zHt3w" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="6.25">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
@@ -3892,12 +3915,12 @@
                   <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
                   <Info min="0" max="14" flag="122" seq="1" ref="0" bb="32" group="41" />
                 </Parameter>
-                <DistributedParameter id="1FR2PlOmTkWnfZrNq-EwJA" name="Effective surface area enhancement factor" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="tTgF-IIKuUuaGCiIUPL1JQ" mode="Logical" isDefault="1">
+                <DistributedParameter id="HZ2VQOsA_UmEpx85Hr_mbw" name="Effective surface area enhancement factor" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="d61NXRcdAkW7ajpb2dLLDA" mode="Logical" isDefault="1">
                   <Children>
-                    <Parameter id="aifSGc01bkGxwwtlTVmj-w" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                    <Parameter id="oVGsjWv0-0a7VhLy3e5WdQ" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
                       <Info min="0" flag="18" seq="1" ref="0" bb="32" group="32" />
                     </Parameter>
-                    <Parameter id="ITwof4XeyEqNipLrQzKqyQ" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="447.9877">
+                    <Parameter id="jAwd0g79ok-mNNu2nxpujQ" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="447.9877">
                       <Info min="0" flag="50" seq="1" ref="0" bb="32" group="32" />
                     </Parameter>
                   </Children>
@@ -3907,234 +3930,237 @@
                   </Tags>
                   <Info min="0" flag="122" seq="1" ref="0" bb="32" group="32" />
                 </DistributedParameter>
-                <Container id="BoFYukRphUWtHABgHauLuw" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="tUnb2Q-vDUCIXIEYX1ByUg" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                   <Children>
-                    <Parameter id="I6ufSWrG2USjFLKuYX_Xfg" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" isDefault="1">
-                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                    <Parameter id="ZWkXDC8VI0y4XeRYKYHdAw" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal_GI" isDefault="1">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                     </Parameter>
-                    <Parameter id="CQ9KcBcnZ0SWdJEX2ZXj-A" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" isDefault="1">
-                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                    <Parameter id="xHR2UR7QpE-AiE05rDZOEA" name="Oral mass absorbed segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" rHSFormula="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_uje" value="0" displayUnit="µmol">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                     </Parameter>
-                    <Parameter id="iqC2zwcukE62p3H-MHT3gQ" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" isDefault="1">
-                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                    <Parameter id="EFLPqsS6N0mpjyhJutc0lg" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                     </Parameter>
-                    <Parameter id="Den6Y1WjSkSUOZaPRZK_KA" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" isDefault="1">
+                    <Parameter id="jNUGVWmUf06ou1BOdytCFg" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="5TrRR6JBv06ihI8BY3pSRw" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" isDefault="1">
+                    <Parameter id="m1lR9JmAaEenM_bEpGypTg" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="IMQ74naN50yN59N2Qv8FDQ" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" isDefault="1">
+                    <Parameter id="pdjY90hoXUCXtyIqPRDuhQ" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="4vxRlzTLDkOjMOEVXQB3lw" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" isDefault="1">
+                    <Parameter id="I1csQitlWEKOeu6W-bS-sg" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="cjdgws-wP0GOdWmQJgvKTg" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" isDefault="1">
+                    <Parameter id="IUlL3dzJyUezAO2cvNFd7g" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="8hR92uec7UOrboHFc7Z7rw" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
-                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                    <Parameter id="dk4Zjsa7FEmn2V7kjNY6Hw" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="pnUG_Tg9ekSNDdbzOAmt2Q" name="Oral mass absorbed segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" rHSFormula="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_uje" value="0" displayUnit="µmol">
-                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                    <Parameter id="GSkzf3rjr0qJmbJvlBl1fg" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="4cTqkn60zkuYzuG6rGu-yQ" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" isDefault="1">
+                    <Parameter id="R6Flk85n1USodQFGn8Y_VQ" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="lC66abfcsE27og57brGIqw" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" isDefault="1">
+                    <Parameter id="cbQh1gB0TECBOa0nk-yixg" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="pZs8Usb2IkOYp7dy80Oayw" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal_GI" isDefault="1">
-                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                    <Parameter id="KWlrR0objE2l0_AA32s0Cw" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="yD80WGYh2EqQQw9smHKzzQ" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" isDefault="1">
+                    <Parameter id="x6xEPj3tiUSVqbBSK5eFbg" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="AnMjwEeqdE2u4SE9YgQt-Q" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
-                      <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                    <Parameter id="oCiMaol5dEaXJAreaEPGJw" name="Solubility" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_IntestinalSolubility" isDefault="1" displayUnit="mg/l">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="42" />
+                    </Parameter>
+                    <Parameter id="uUMHjf8UO0qIx00e2fm84A" name="Solubility table" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.TableFormulaWithXArgument_SolubilityTable" isDefault="1" displayUnit="mg/l">
+                      <Info min="0" flag="50" seq="1" ref="0" bb="2" group="42" />
                     </Parameter>
-                    <Parameter id="lqkKWheRokehhTQXko9DSg" name="Solubility_pKa_pH_Factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" isDefault="1">
+                    <Parameter id="2nIpDD36CEO2i9xZ98PEnQ" name="Solubility_pKa_pH_Factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="NVenFYeOsk2EJSRRndB_qg" name="Solubility table" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.TableFormulaWithXArgument_SolubilityTable" isDefault="1" displayUnit="mg/l">
-                      <Info min="0" flag="50" seq="1" ref="0" bb="2" group="42" />
+                    <Parameter id="aJQlLsxs2U2Fr1n4QXAjgA" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                      <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                     </Parameter>
-                    <Parameter id="gKP8_CGzykGmz7bzzxX3xg" name="Solubility" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_IntestinalSolubility" isDefault="1" displayUnit="mg/l">
-                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="42" />
+                    <Parameter id="AJIq0pnjr0GO11O9o5rJyQ" name="Effective concentration in lumen" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_EffectiveLumenConcentration" isDefault="1" displayUnit="µmol/l">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="42" />
                     </Parameter>
                   </Children>
                 </Container>
               </Children>
             </Container>
-            <Container id="kkxzQN9__kSp5W5wsE_IgA" name="LowerJejunum" mode="Physical" containerType="Compartment">
+            <Container id="Cc6q_6QFp0iNzXJMnzp5vQ" name="LowerJejunum" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="Lumen" />
                 <Tag value="LumenSegment" />
               </Tags>
               <Children>
-                <Parameter id="CnsTmj_uakqf90k3mZJsLQ" name="Proximal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R1" isDefault="1" displayUnit="cm">
+                <Parameter id="hKxD_tRDYkapRL_EA0-kGQ" name="Absorption of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Outflow_LowerJejunum" isDefault="1" displayUnit="1/min">
+                  <Info flag="54" seq="1" ref="0" bb="2" group="63" />
+                </Parameter>
+                <Parameter id="lxNrR0PVuUmuaDMRiJyHZg" name="Distal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R2" isDefault="1" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="BbkgDelG60mo1yzWQXWJQw" name="Secretion of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Inflow_LowerJejunum" isDefault="1" displayUnit="l/min">
-                  <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
-                </Parameter>
-                <Parameter id="5uYBMM13kk2e1PUi4-Knyw" name="Thickness of gut wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Thickness" isDefault="1" displayUnit="cm">
+                <Parameter id="1zRpqh-V6U2iaV576lWXRg" name="Effective surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_EffectiveSurfaceArea" isDefault="1" displayUnit="cm²">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="38" seq="1" ref="0" bb="32" group="45" />
+                  <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
+                  <Info min="0" flag="52" seq="1" ref="0" bb="32" group="33" />
                 </Parameter>
-                <Parameter id="7oW6B3jLwE-9lxXfVdg88w" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_LumenSegment" isDefault="1" displayUnit="l">
-                  <Info min="0" flag="62" seq="1" ref="0" bb="2" group="56" />
+                <Parameter id="u5tAu9Sb_k267jZOF14OKQ" name="FillLevelFlag" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevelFlagFlag" isDefault="1">
+                  <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                </Parameter>
+                <Parameter id="m7so7ZfE4ECrhOSNkf4R_g" name="Fraction of geometric volume filled with liquid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevel" isDefault="1">
+                  <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="l7j94PI5yEWJwAoCV7B5XA" name="Volume (gut wall)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="MucosaVolume_Human.PARAM_VolumeGutWall_LowerJejunum" isDefault="1" displayUnit="l">
+                <Parameter id="3caD2adnX0-ctdW41Mms3Q" name="Geometric surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Area" isDefault="1" displayUnit="cm²">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="62" seq="1" ref="0" bb="32" group="44" />
+                  <Info min="0" flag="62" seq="1" ref="0" bb="32" group="33" />
+                </Parameter>
+                <Parameter id="xI7Th1nHTUKIFFYcq15MSg" name="Intestinal transit rate (absolute)" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_InverseSITT_Factor_LowerJejunum" isDefault="1" displayUnit="1/min">
+                  <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="6wPlsb7zqESwDpsRbzV7HA" name="Length" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Length" isDefault="1" displayUnit="cm">
+                <Parameter id="dRziknfsMkiFSH2M1ZiiQg" name="Length" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Length" isDefault="1" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info min="0" flag="106" seq="1" ref="0" bb="32" group="34" />
                 </Parameter>
-                <Parameter id="VwyCTlzWuEOczqFaNracJQ" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
-                  <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
-                </Parameter>
-                <Parameter id="xfHJTIFIgUeZdI2Q47i9qw" name="Liquid transfer rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_LiquidTransferRate_lje" isDefault="1" displayUnit="l/min">
-                  <Info flag="52" seq="1" ref="0" bb="2" group="39" />
-                </Parameter>
-                <Parameter id="5RntynEVu0630sjIbmXWcg" name="Liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Liquid_StartValue" isDefault="1" rHSFormula="Lumen_PKSim.LiquidRHS_lje" displayUnit="l">
+                <Parameter id="M6MXeYVL40uC4IglHBNDsg" name="Liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Liquid_StartValue" isDefault="1" rHSFormula="Lumen_PKSim.LiquidRHS_lje" displayUnit="l">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="gQcqWEmiLU6qDbvaV5R4Og" name="Absorption of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Outflow_LowerJejunum" isDefault="1" displayUnit="1/min">
-                  <Info flag="54" seq="1" ref="0" bb="2" group="63" />
+                <Parameter id="VF64SppetUS3Izs5L96EWw" name="Liquid transfer rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_LiquidTransferRate_lje" isDefault="1" displayUnit="l/min">
+                  <Info flag="52" seq="1" ref="0" bb="2" group="39" />
                 </Parameter>
-                <Parameter id="GAdJ85JjY0i0kDwKrNK6vA" name="Distal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R2" isDefault="1" displayUnit="cm">
+                <Parameter id="_V8lX99AY0iSSQg2A5Diyg" name="Proximal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R1" isDefault="1" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="ejByWFEAoUO0Rpn5SbTHhg" name="Effective surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_EffectiveSurfaceArea" isDefault="1" displayUnit="cm²">
+                <Parameter id="WHVNmwam00G7VG-PxgdPkQ" name="Secretion of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Inflow_LowerJejunum" isDefault="1" displayUnit="l/min">
+                  <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                </Parameter>
+                <Parameter id="hfhPrXzOykq05AVjT1DdoQ" name="Thickness of gut wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Thickness" isDefault="1" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
-                  <Info min="0" flag="52" seq="1" ref="0" bb="32" group="33" />
-                </Parameter>
-                <Parameter id="_hTI8Z4RyE6f3nQRgJRpiA" name="FillLevelFlag" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevelFlagFlag" isDefault="1">
-                  <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                  <Info min="0" flag="38" seq="1" ref="0" bb="32" group="45" />
                 </Parameter>
-                <Parameter id="XQE9x1n-QkGBWOguxlXK5g" name="Fraction of geometric volume filled with liquid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevel" isDefault="1">
-                  <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                <Parameter id="4Wcu0Y_uzEuzP1q8xasALw" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_LumenSegment" isDefault="1" displayUnit="l">
+                  <Info min="0" flag="62" seq="1" ref="0" bb="2" group="56" />
                 </Parameter>
-                <Parameter id="FTU9GsBPMka4rYQ3PeKNWQ" name="Geometric surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Area" isDefault="1" displayUnit="cm²">
+                <Parameter id="7bgCAlyKL0mwjBKNJtupxg" name="Volume (gut wall)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="MucosaVolume_Human.PARAM_VolumeGutWall_LowerJejunum" isDefault="1" displayUnit="l">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="62" seq="1" ref="0" bb="32" group="33" />
+                  <Info min="0" flag="62" seq="1" ref="0" bb="32" group="44" />
                 </Parameter>
-                <Parameter id="ECgV6amSEEG2fGQLxBGNuA" name="Intestinal transit rate (absolute)" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_InverseSITT_Factor_LowerJejunum" isDefault="1" displayUnit="1/min">
-                  <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                <Parameter id="uUNzeYFcsEKSn6figISErA" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                  <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                 </Parameter>
-                <Parameter id="-lK-Pjlj1EWUUylyp1X_ow" name="Thickness_p3" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.30703115" displayUnit="1/cm">
+                <Parameter id="VhUKQJRCnEO9OGPJS7et-g" name="Fractional steady state fill level" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.064841">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                  <Info min="0" flag="58" seq="1" ref="0" bb="32" group="43" />
                 </Parameter>
-                <Parameter id="BX77oyA91kOEk4W0O_DE5g" name="L_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.299751712">
+                <Parameter id="2BWc8ZTbBEq0bIXPUPXDAw" name="Intestinal transit rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="5.0162" displayUnit="1/min">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="34" />
+                  <Info min="0" flag="54" seq="1" ref="0" bb="32" group="46" />
                 </Parameter>
-                <Parameter id="W2wvC1O8W0STKYxi-EojaQ" name="Thickness_p2" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0465856499" displayUnit="cm">
+                <Parameter id="tHjQbd7maEWY3Pyhneildw" name="L_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0670329582" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="34" />
                 </Parameter>
-                <Parameter id="IEjiKK-VZUS4a_WuQae0Qw" name="Thickness_p1" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0196976609" displayUnit="cm">
+                <Parameter id="R2gvox9-l0acy_DxZ4iMhw" name="L_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.299751712">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="34" />
                 </Parameter>
-                <Parameter id="FwlJMiUza0aVBafS0ueyag" name="r2_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.008101398">
+                <Parameter id="FLU5oZT4uUubSWIOAUihPA" name="Microvilli factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="25">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                  <Info min="0" flag="38" seq="1" ref="0" bb="32" group="33" />
                 </Parameter>
-                <Parameter id="Xo3bHQEvQ0GaSrf2AmpEzA" name="r2_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0018117016" displayUnit="cm">
+                <Parameter id="hruOZUpl90iKFUT_59hMAA" name="r1_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0019411088" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="UJWS04usjUWYekAOFSd_6Q" name="r1_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.008680069">
+                <Parameter id="JxYZW04FgEKuN9A8V0AK-g" name="r1_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.008680069">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="60EXKQCQyEi_WQHDXS5mhA" name="Microvilli factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="25">
+                <Parameter id="Nc0NhOCmgUCobd9pKRWJnQ" name="r2_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0018117016" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="38" seq="1" ref="0" bb="32" group="33" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="3KBSZVM6TUakXJdg86n_YQ" name="L_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0670329582" displayUnit="cm">
+                <Parameter id="-ZgLf0XegU6Fjxh3C8g-Ew" name="r2_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.008101398">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="34" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="-dQ8Oe3jf0CuorX_1PZtLA" name="Intestinal transit rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="5.0162" displayUnit="1/min">
+                <Parameter id="OFuegx2VSUWDRFHsMj7WqQ" name="Thickness_p1" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0196976609" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="54" seq="1" ref="0" bb="32" group="46" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
                 </Parameter>
-                <Parameter id="hFcESlLSTEK6csSnckiFZg" name="Fractional steady state fill level" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.064841">
+                <Parameter id="55CAk1D0JkSmLB_OekfUjQ" name="Thickness_p2" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0465856499" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="58" seq="1" ref="0" bb="32" group="43" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
                 </Parameter>
-                <Parameter id="C53STXeCjU-xCF36LZ8jKA" name="r1_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0019411088" displayUnit="cm">
+                <Parameter id="LIB7eAMMs0-N2CiayCAs3g" name="Thickness_p3" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.30703115" displayUnit="1/cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
                 </Parameter>
-                <Parameter id="WdWuYUOafkCOaq7MqDAUbg" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="6.9167">
+                <Parameter id="BcbdMoZw1Uimvi-TSNNlWg" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="6.9167">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
@@ -4142,12 +4168,12 @@
                   <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
                   <Info min="0" max="14" flag="122" seq="1" ref="0" bb="32" group="41" />
                 </Parameter>
-                <DistributedParameter id="wtAvp6AR_kKJIW-_o6iUqQ" name="Effective surface area enhancement factor" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Shb76B5HY0aX3iBbMgYq1A" mode="Logical" isDefault="1">
+                <DistributedParameter id="wie0fs2CbUumJ4gvAqmKDA" name="Effective surface area enhancement factor" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="EVTYqrRIKUGiF14RsKdnTA" mode="Logical" isDefault="1">
                   <Children>
-                    <Parameter id="-7to3N_M_Ua4Z_81pO2hwA" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                    <Parameter id="M8SmFy-Hc0mJHZrLLCwhKg" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
                       <Info min="0" flag="18" seq="1" ref="0" bb="32" group="32" />
                     </Parameter>
-                    <Parameter id="rJqYb_-bp0y_g6jcUdvpyQ" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="372.9358">
+                    <Parameter id="1KNZROo3L0WP9XWwnZCZaw" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="372.9358">
                       <Info min="0" flag="50" seq="1" ref="0" bb="32" group="32" />
                     </Parameter>
                   </Children>
@@ -4157,90 +4183,86 @@
                   </Tags>
                   <Info min="0" flag="122" seq="1" ref="0" bb="32" group="32" />
                 </DistributedParameter>
-                <Container id="ctieOtceckKSRTlp1GKW2A" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="s-N98VMWOEC2aRZ-C8jcSQ" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                   <Children>
-                    <Parameter id="ANlww9cWO0S_cVvvPBPCkA" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" isDefault="1">
-                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
-                    </Parameter>
-                    <Parameter id="PGIvtxA-3Um1SgsNOPonIg" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal_GI" isDefault="1">
+                    <Parameter id="M3euZnjU2EuvYKGVmBW66w" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal_GI" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                     </Parameter>
-                    <Parameter id="HsQz04BbpkGdBHFUJm67cg" name="Oral mass absorbed segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" rHSFormula="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_lje" value="0" displayUnit="µmol">
+                    <Parameter id="iV9S3a8CSE2sev-pCRBQZQ" name="Oral mass absorbed segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" rHSFormula="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_lje" value="0" displayUnit="µmol">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                     </Parameter>
-                    <Parameter id="lI8o4ZSSHUeTZZphUrktIw" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                    <Parameter id="lUS5QW_p7kWzdhIopiQWqQ" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                     </Parameter>
-                    <Parameter id="qKZoYh97ZkeQjlU6szs6vw" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" isDefault="1">
+                    <Parameter id="7syr-SiIEUGlcA1UA8BVvg" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="hy6_4GLW0E-2-km6FsYU1Q" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" isDefault="1">
+                    <Parameter id="dHPuBKOvAE2i6YGtNFWLEQ" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="WF_SO_tpFUm-viNZRED6aQ" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" isDefault="1">
+                    <Parameter id="pKuhu53fsEW9vtYRwqDTow" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="MzAeIHfidUGRllyQqi683A" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" isDefault="1">
+                    <Parameter id="jKBsha2jk0qjQlfCF39I5A" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="e6ouO43QjUun7Ova2rq4AA" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" isDefault="1">
+                    <Parameter id="JS46l2UlKkScEnEVFCqQBA" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="l87PjRR02kS9vhagFtuo6A" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" isDefault="1">
+                    <Parameter id="xref8Xi60k2Ydg7pkAA1Lw" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="Yb494cdhjka4hSU0gnHYSw" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" isDefault="1">
+                    <Parameter id="n-YFebRuB06EuuCE6IM2pA" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="-EJgooyE-0OTULhv5pfYtg" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" isDefault="1">
+                    <Parameter id="u-gPmpeajEyOShRCKp8g7A" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="dB5pax7KIUieU7je-0KvNA" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" isDefault="1">
+                    <Parameter id="0n8UjTO8G0GQoU0pGo9eJg" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="iW_tgS9ukkKIQNT7SblLRA" name="Solubility" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_IntestinalSolubility" isDefault="1" displayUnit="mg/l">
+                    <Parameter id="enwlVvOeukavPt9LqPWvlQ" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                    </Parameter>
+                    <Parameter id="Wjkgsfr5-E-geh5aNZBEtw" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                    </Parameter>
+                    <Parameter id="MGP7h7wCpkKu9xiOkUEFYQ" name="Solubility" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_IntestinalSolubility" isDefault="1" displayUnit="mg/l">
                       <Info min="0" flag="122" seq="1" ref="0" bb="2" group="42" />
                     </Parameter>
-                    <Parameter id="hpUiL0x_RUKJ0e22EQUySw" name="Solubility table" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.TableFormulaWithXArgument_SolubilityTable" isDefault="1" displayUnit="mg/l">
+                    <Parameter id="hx7coYNxukqRdThcKlzH6A" name="Solubility table" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.TableFormulaWithXArgument_SolubilityTable" isDefault="1" displayUnit="mg/l">
                       <Info min="0" flag="50" seq="1" ref="0" bb="2" group="42" />
                     </Parameter>
-                    <Parameter id="7QM3fVgfH0Kxg5uJA_DpLg" name="Solubility_pKa_pH_Factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" isDefault="1">
+                    <Parameter id="8uWvTCB-WEmVh_6ws-QR4w" name="Solubility_pKa_pH_Factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="6HkR_AsteEyd0h8d_kRw5g" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                    <Parameter id="YLUswbmYmE-xKWyxgT1rlQ" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
                       <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                     </Parameter>
-                    <Parameter id="O3FBID9YYkSebYtjlrYB3A" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" isDefault="1">
-                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                    <Parameter id="7Df-NO0emkqk5_cr4_yxOw" name="Effective concentration in lumen" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_EffectiveLumenConcentration" isDefault="1" displayUnit="µmol/l">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="42" />
                     </Parameter>
                   </Children>
                 </Container>
               </Children>
             </Container>
-            <Container id="ESTEWsLHx0OLfQr-M3hs1A" name="UpperIleum" mode="Physical" containerType="Compartment">
+            <Container id="sCpNhHJQCEWV2oakLgPUew" name="UpperIleum" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="Lumen" />
                 <Tag value="LumenSegment" />
               </Tags>
               <Children>
-                <Parameter id="odF_ZmWFPkKW-slg7b4BaQ" name="Distal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R2" isDefault="1" displayUnit="cm">
-                  <Tags>
-                    <Tag value="Lumen" />
-                    <Tag value="LumenSegment" />
-                  </Tags>
-                  <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
+                <Parameter id="7kp_rnlW10SHEiSAPm3gYw" name="Absorption of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Outflow_UpperIleum" isDefault="1" displayUnit="1/min">
+                  <Info flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="ahIN2UODH0uEiKMvt-ozMQ" name="Proximal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R1" isDefault="1" displayUnit="cm">
+                <Parameter id="AKVZaH7PqE-9tfhKdrg-Zw" name="Distal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R2" isDefault="1" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="Mldfs_66X0qRDALi6DRb4g" name="Absorption of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Outflow_UpperIleum" isDefault="1" displayUnit="1/min">
-                  <Info flag="54" seq="1" ref="0" bb="2" group="63" />
-                </Parameter>
-                <Parameter id="RU8eSEFhDEa68jEjZ6WS-w" name="Effective surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_EffectiveSurfaceArea" isDefault="1" displayUnit="cm²">
+                <Parameter id="jdjuirSa3kC236FV-Qz3tw" name="Effective surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_EffectiveSurfaceArea" isDefault="1" displayUnit="cm²">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
@@ -4248,143 +4270,150 @@
                   <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
                   <Info min="0" flag="52" seq="1" ref="0" bb="32" group="33" />
                 </Parameter>
-                <Parameter id="Pg6YB9jeyUS5ZldL1jj2AQ" name="FillLevelFlag" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevelFlagFlag" isDefault="1">
+                <Parameter id="OyJk5I6f3EiGTkS3sJpKnQ" name="FillLevelFlag" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevelFlagFlag" isDefault="1">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="lkxym2E480emmWTUAEPpjA" name="Fraction of geometric volume filled with liquid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevel" isDefault="1">
+                <Parameter id="YiUdqepAmE2fVWTwlmJwCw" name="Fraction of geometric volume filled with liquid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevel" isDefault="1">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="cFARyaDCEkqgpNiJtI1jAg" name="Geometric surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Area" isDefault="1" displayUnit="cm²">
+                <Parameter id="K2mgrL313kGN9B5tWMVDVA" name="Geometric surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Area" isDefault="1" displayUnit="cm²">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info min="0" flag="62" seq="1" ref="0" bb="32" group="33" />
                 </Parameter>
-                <Parameter id="kLkOR1P690KYiMepq3S_JA" name="Intestinal transit rate (absolute)" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_InverseSITT_Factor_UpperIleum" isDefault="1" displayUnit="1/min">
+                <Parameter id="6aXwchl8tkyfM7eGBjmStA" name="Intestinal transit rate (absolute)" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_InverseSITT_Factor_UpperIleum" isDefault="1" displayUnit="1/min">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="orRiuQZJUkeD0hNn2IFdqw" name="Length" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Length" isDefault="1" displayUnit="cm">
+                <Parameter id="KirqxVIlBE6K9zLSyTQUig" name="Length" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Length" isDefault="1" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info min="0" flag="106" seq="1" ref="0" bb="32" group="34" />
                 </Parameter>
-                <Parameter id="6OZ_7RPbYkqq11FyxDE5tQ" name="Liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Liquid_StartValue" isDefault="1" rHSFormula="Lumen_PKSim.LiquidRHS_uil" displayUnit="l">
-                  <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
-                </Parameter>
-                <Parameter id="S8J0-xV7tEiNtZHiJ938VQ" name="Secretion of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Inflow_UpperIleum" isDefault="1" displayUnit="l/min">
+                <Parameter id="xcVsWO0v5kqbSYYRj0sWXA" name="Liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Liquid_StartValue" isDefault="1" rHSFormula="Lumen_PKSim.LiquidRHS_uil" displayUnit="l">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="kmMuerzp0EK7-RCgNnsohw" name="Liquid transfer rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_LiquidTransferRate_uil" isDefault="1" displayUnit="l/min">
+                <Parameter id="YZ24989ZdUODDLou-UuEhA" name="Liquid transfer rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_LiquidTransferRate_uil" isDefault="1" displayUnit="l/min">
                   <Info flag="52" seq="1" ref="0" bb="2" group="39" />
                 </Parameter>
-                <Parameter id="T6r0xEzFBUWlzHpZYslkCA" name="Thickness of gut wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Thickness" isDefault="1" displayUnit="cm">
+                <Parameter id="5ua2bD9V9EyvYqNpFoFdqA" name="Proximal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R1" isDefault="1" displayUnit="cm">
+                  <Tags>
+                    <Tag value="Lumen" />
+                    <Tag value="LumenSegment" />
+                  </Tags>
+                  <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
+                </Parameter>
+                <Parameter id="vUVhEBsCsUaIhyvy-M42hw" name="Secretion of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Inflow_UpperIleum" isDefault="1" displayUnit="l/min">
+                  <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                </Parameter>
+                <Parameter id="MtySm83fjEuYIbeAiHg9uA" name="Thickness of gut wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Thickness" isDefault="1" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info min="0" flag="38" seq="1" ref="0" bb="32" group="45" />
                 </Parameter>
-                <Parameter id="B2BpJr8bbU--IVQw5xzbsA" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_LumenSegment" isDefault="1" displayUnit="l">
+                <Parameter id="Eum5pzzrcUO2IBsGfWjOZA" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_LumenSegment" isDefault="1" displayUnit="l">
                   <Info min="0" flag="62" seq="1" ref="0" bb="2" group="56" />
                 </Parameter>
-                <Parameter id="y478ACxzVkqBl-db7YXjQw" name="Volume (gut wall)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="MucosaVolume_Human.PARAM_VolumeGutWall_UpperIleum" isDefault="1" displayUnit="l">
+                <Parameter id="G24p81XPwUWaMpQ7oSI9pA" name="Volume (gut wall)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="MucosaVolume_Human.PARAM_VolumeGutWall_UpperIleum" isDefault="1" displayUnit="l">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info min="0" flag="62" seq="1" ref="0" bb="32" group="44" />
                 </Parameter>
-                <Parameter id="Aqcr7SjTOkylli8KqsPgQw" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                <Parameter id="z2gDJr57IES1hcspL6L4Qw" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
                   <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                 </Parameter>
-                <Parameter id="BHN9wRi5_UGNN_NLyt0U0A" name="r2_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0015528871" displayUnit="cm">
+                <Parameter id="6udicvQRjESfCeB5xBz0AQ" name="Fractional steady state fill level" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.064841">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                  <Info min="0" flag="58" seq="1" ref="0" bb="32" group="43" />
                 </Parameter>
-                <Parameter id="Gz_-8n8OL0e7ucCED72g5Q" name="Thickness_p3" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.30703115" displayUnit="1/cm">
+                <Parameter id="C-yNq9Stg021Sj9b07WIpA" name="Intestinal transit rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="3.3745" displayUnit="1/min">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                  <Info min="0" flag="54" seq="1" ref="0" bb="32" group="46" />
                 </Parameter>
-                <Parameter id="Ypnv1c8eskW2PGkOXHPVRg" name="Thickness_p2" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.061552122" displayUnit="cm">
+                <Parameter id="54NsO_1ZA0-42L4-A24e6w" name="L_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0996435866" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="34" />
                 </Parameter>
-                <Parameter id="QRxtzUh_ckC4JQcJN5B-Kw" name="r2_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.006944055">
+                <Parameter id="KzB7N1kQwkyxSCAKdZaGgQ" name="L_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.445576869">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="34" />
                 </Parameter>
-                <Parameter id="Jn1aDS1Mt0ShiPYS4480bQ" name="r1_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.008101398">
+                <Parameter id="nrx2mWvMuESAmLWFHoe9jg" name="Microvilli factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="25">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                  <Info min="0" flag="38" seq="1" ref="0" bb="32" group="33" />
                 </Parameter>
-                <Parameter id="c-_JSGz-70igleEBjmgqsA" name="r1_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0018117016" displayUnit="cm">
+                <Parameter id="nPMV1SPxUEuOKzlXmUmkwQ" name="r1_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0018117016" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="v9AkTqQWrUW308V1rNgz_A" name="Microvilli factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="25">
+                <Parameter id="5pyLJhPVLECV8847PfE7UQ" name="r1_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.008101398">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="38" seq="1" ref="0" bb="32" group="33" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="CUP5NbdKGUmmNLDXQhIbVw" name="L_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.445576869">
+                <Parameter id="-3xyGFvdLUOeqhvROw1Gcw" name="r2_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0015528871" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="34" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="TkmbnIE1pkubQzGJeQrZ0A" name="L_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0996435866" displayUnit="cm">
+                <Parameter id="0kK-8efcW0GL-SuZvWF5Uw" name="r2_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.006944055">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="34" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="tbkKdnG3YUm-elMYqTeggQ" name="Intestinal transit rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="3.3745" displayUnit="1/min">
+                <Parameter id="oJsk0Bo4FUqVHhS6UT2UFg" name="Thickness_p1" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0260258863" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="54" seq="1" ref="0" bb="32" group="46" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
                 </Parameter>
-                <Parameter id="obogI-qfXkeAfMXzQ_AMcQ" name="Thickness_p1" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0260258863" displayUnit="cm">
+                <Parameter id="89Nv45LN3kW7Hfu43V1aiw" name="Thickness_p2" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.061552122" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info flag="54" seq="1" ref="0" bb="32" group="45" />
                 </Parameter>
-                <Parameter id="qU7Y5HpsDEmmfXxrRqgwBg" name="Fractional steady state fill level" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.064841">
+                <Parameter id="_WXDSbEYIkGUPu4Ci5gcAg" name="Thickness_p3" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.30703115" displayUnit="1/cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="58" seq="1" ref="0" bb="32" group="43" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
                 </Parameter>
-                <Parameter id="bbIdxmbCfE6eoexs_RDl-w" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.2083">
+                <Parameter id="ceuzIxhgtkO4KteJCdFA9A" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.2083">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
@@ -4392,12 +4421,12 @@
                   <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
                   <Info min="0" max="14" flag="122" seq="1" ref="0" bb="32" group="41" />
                 </Parameter>
-                <DistributedParameter id="RmbgJ-cWkESBDd1a6-ZZIw" name="Effective surface area enhancement factor" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="1iHGfck3IEmcfb4HGD-eYQ" mode="Logical" isDefault="1">
+                <DistributedParameter id="YdgQAK55XkCaW3LJTFpLaw" name="Effective surface area enhancement factor" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="otMOlwHwOEmuDWB20OpafQ" mode="Logical" isDefault="1">
                   <Children>
-                    <Parameter id="jBFcAPVgvEGuvQFBu5cBhw" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                    <Parameter id="rivsIvIylEaNp3FBLuPKdg" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
                       <Info min="0" flag="18" seq="1" ref="0" bb="32" group="32" />
                     </Parameter>
-                    <Parameter id="f3ue6LTepkSieurjMb4_Bg" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="260.7527">
+                    <Parameter id="P-BD-ZbgOke0Zrq2TNwDaA" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="260.7527">
                       <Info min="0" flag="50" seq="1" ref="0" bb="32" group="32" />
                     </Parameter>
                   </Children>
@@ -4407,99 +4436,86 @@
                   </Tags>
                   <Info min="0" flag="122" seq="1" ref="0" bb="32" group="32" />
                 </DistributedParameter>
-                <Container id="2mOdsBAzZk-gymCRIJSing" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="mrWYlikwiU6soGL9tbQFyA" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                   <Children>
-                    <Parameter id="w7bNuZrbBE-7QHVG4FV9aw" name="Solubility_pKa_pH_Factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" isDefault="1">
-                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="18" />
+                    <Parameter id="pbrTheVABUeWEIf46JsZuQ" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal_GI" isDefault="1">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                     </Parameter>
-                    <Parameter id="3TheOJmpv0-4OnHZp5rKSw" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
-                      <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                    <Parameter id="ZHUBqZ6XkkG94yr--11XBA" name="Oral mass absorbed segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" rHSFormula="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_uil" value="0" displayUnit="µmol">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                     </Parameter>
-                    <Parameter id="xUjsQeEPCkKdkr-mNGPIFw" name="Solubility table" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.TableFormulaWithXArgument_SolubilityTable" isDefault="1" displayUnit="mg/l">
-                      <Info min="0" flag="50" seq="1" ref="0" bb="2" group="42" />
+                    <Parameter id="JPkkonEftUW6WpjTjshtPw" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                     </Parameter>
-                    <Parameter id="uh100z3uI0GzlNaQ6JAEOA" name="Solubility" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_IntestinalSolubility" isDefault="1" displayUnit="mg/l">
-                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="42" />
+                    <Parameter id="Rd3j6IjIe0Of6kl3B49wvw" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="T9B4TjUuPkGNWAlIKd7k3g" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" isDefault="1">
+                    <Parameter id="jJXhcdYybUid8a6VEh-Mew" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="L6CH_N-HFEWHuxJWYd3qqg" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" isDefault="1">
+                    <Parameter id="nXDZiLBpHUS4Ou5eetSndQ" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="QOV_0L6D40qSo4iojVbURA" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" isDefault="1">
+                    <Parameter id="fX1gF1R7okmgcgLGp9gGIA" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="aCMmH27uNkW5zeO1b47sLw" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" isDefault="1">
+                    <Parameter id="Lr3JRzapGEW_v3kl8M103g" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="hF8-FjTbD0y0z18F28o2hg" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" isDefault="1">
+                    <Parameter id="FvwTIy4CwEmYr-jTAHG6UA" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="TJdz6MzYv0-qH9RiY2jVKQ" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" isDefault="1">
+                    <Parameter id="7jQNICVWfUqPlqrSWEqRNQ" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="vBgup2ccmUyI1u1Mmndy2g" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" isDefault="1">
+                    <Parameter id="usiUcQCM10WLqcB4ZYOyag" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="oJQ76n1fwkmQpaOPkkA6Vg" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" isDefault="1">
+                    <Parameter id="-5XlsrITqUyBiE6KoobU8Q" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="f9fWauvArEGGkGFGqIK5jw" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" isDefault="1">
+                    <Parameter id="2yxUheGAAkWXzFXG_xuF7A" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="PJUkQNTi002U3z3V9SgW4Q" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal_GI" isDefault="1">
-                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                    <Parameter id="iwY4h3ut-kKI7wYGV-lEzw" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="R45WrWUuo0KumduH2kJAdA" name="Oral mass absorbed segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" rHSFormula="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_uil" value="0" displayUnit="µmol">
-                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                    <Parameter id="JLaWmDT_q0q9tNGGdGLYqA" name="Solubility" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_IntestinalSolubility" isDefault="1" displayUnit="mg/l">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="42" />
                     </Parameter>
-                    <Parameter id="kM3KR0oW-U-yi30vUMwwhw" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
-                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                    <Parameter id="wUr_PD7DCU-HHB2ipwKj9g" name="Solubility table" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.TableFormulaWithXArgument_SolubilityTable" isDefault="1" displayUnit="mg/l">
+                      <Info min="0" flag="50" seq="1" ref="0" bb="2" group="42" />
                     </Parameter>
-                    <Parameter id="nxJGd7JFDkqvSraQuwIMTQ" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" isDefault="1">
-                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                    <Parameter id="tKj_MuuxF0-LQ9uF_Cd6VA" name="Solubility_pKa_pH_Factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" isDefault="1">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="ohiu0GOvo0-KvRW7z9o_pQ" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" isDefault="1">
-                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                    <Parameter id="2nr5nw9u30yIVEsMCfrMVA" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                      <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                    </Parameter>
+                    <Parameter id="Ya7kyjG2KEG7fzpaWMdA_g" name="Effective concentration in lumen" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_EffectiveLumenConcentration" isDefault="1" displayUnit="µmol/l">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="42" />
                     </Parameter>
                   </Children>
                 </Container>
               </Children>
             </Container>
-            <Container id="Lb1SPQ-6FkGtMC4KAGRoSA" name="LowerIleum" mode="Physical" containerType="Compartment">
+            <Container id="WhhY_lqxWkWM0OtpLodvWw" name="LowerIleum" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="Lumen" />
                 <Tag value="LumenSegment" />
               </Tags>
               <Children>
-                <Parameter id="jhYqjaLSrUWy92rJzFYGjw" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_LumenSegment" isDefault="1" displayUnit="l">
-                  <Info min="0" flag="62" seq="1" ref="0" bb="2" group="56" />
-                </Parameter>
-                <Parameter id="iV3Wu2l5uUee2XfJTFGbeA" name="Volume (gut wall)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="MucosaVolume_Human.PARAM_VolumeGutWall_LowerIleum" isDefault="1" displayUnit="l">
-                  <Tags>
-                    <Tag value="Lumen" />
-                    <Tag value="LumenSegment" />
-                  </Tags>
-                  <Info min="0" flag="62" seq="1" ref="0" bb="32" group="44" />
-                </Parameter>
-                <Parameter id="Sh7aPlGirUOuIAyVWPJlFw" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
-                  <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                <Parameter id="I33svR7Qg0W09EtKvkAhAQ" name="Absorption of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Outflow_LowerIleum" isDefault="1" displayUnit="1/min">
+                  <Info flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="cfzbnvJYwkO_oxA_dxi0Nw" name="Thickness of gut wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Thickness" isDefault="1" displayUnit="cm">
+                <Parameter id="fJtWDTEJp0mCx2agSMoQqw" name="Distal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R2" isDefault="1" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="38" seq="1" ref="0" bb="32" group="45" />
-                </Parameter>
-                <Parameter id="gt82y5U1Hka-99Pb2b5Gmg" name="FillLevelFlag" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevelFlagFlag" isDefault="1">
-                  <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
-                </Parameter>
-                <Parameter id="dXww7Xt5E0iZTo6V4MUVXw" name="Absorption of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Outflow_LowerIleum" isDefault="1" displayUnit="1/min">
-                  <Info flag="54" seq="1" ref="0" bb="2" group="63" />
+                  <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="njQkKJf0fEiXnk1SQqkQ8w" name="Effective surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_EffectiveSurfaceArea" isDefault="1" displayUnit="cm²">
+                <Parameter id="PHhOyDQCn0SlvKxH8yizOw" name="Effective surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_EffectiveSurfaceArea" isDefault="1" displayUnit="cm²">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
@@ -4507,147 +4523,163 @@
                   <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
                   <Info min="0" flag="52" seq="1" ref="0" bb="32" group="33" />
                 </Parameter>
-                <Parameter id="-IBmQstCqUazGo_R_U34ug" name="Fraction of geometric volume filled with liquid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevel" isDefault="1">
+                <Parameter id="kclo2ukl9UumX2v80MjRvQ" name="FillLevelFlag" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevelFlagFlag" isDefault="1">
+                  <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                </Parameter>
+                <Parameter id="eZ5V4_db00O726pKwnL66g" name="Fraction of geometric volume filled with liquid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevel" isDefault="1">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="OMkZ0-TFDUyqAsG7QQvxRQ" name="Geometric surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Area" isDefault="1" displayUnit="cm²">
+                <Parameter id="xbXKZVlip06X-VBQDRV4GA" name="Geometric surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Area" isDefault="1" displayUnit="cm²">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info min="0" flag="62" seq="1" ref="0" bb="32" group="33" />
                 </Parameter>
-                <Parameter id="NqodOPheN02XhRRlZOkc0w" name="Intestinal transit rate (absolute)" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_InverseSITT_Factor_LowerIleum" isDefault="1" displayUnit="1/min">
+                <Parameter id="RdQP7xqEmUKQCtUAt8ibCA" name="Intestinal transit rate (absolute)" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_InverseSITT_Factor_LowerIleum" isDefault="1" displayUnit="1/min">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="m0Sxctb5i069YOIPzDdAuw" name="Length" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Length" isDefault="1" displayUnit="cm">
+                <Parameter id="Zx5uxlbBxUugMCgMWoBBPA" name="Length" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Length" isDefault="1" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info min="0" flag="106" seq="1" ref="0" bb="32" group="34" />
                 </Parameter>
-                <Parameter id="VWZ-GCZHDk2ShQYMhzsyYA" name="Liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Liquid_StartValue" isDefault="1" rHSFormula="Lumen_PKSim.LiquidRHS_lil" displayUnit="l">
+                <Parameter id="a1A2mbxr2U-hbPQ7oCgecg" name="Liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Liquid_StartValue" isDefault="1" rHSFormula="Lumen_PKSim.LiquidRHS_lil" displayUnit="l">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="u-O8HN1YS0q-ao1RrSOsMg" name="Liquid transfer rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_LiquidTransferRate_lil" isDefault="1" displayUnit="l/min">
+                <Parameter id="FTD3WOuxNUewEYdgPDHbMw" name="Liquid transfer rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_LiquidTransferRate_lil" isDefault="1" displayUnit="l/min">
                   <Info flag="52" seq="1" ref="0" bb="2" group="39" />
                 </Parameter>
-                <Parameter id="zu6fIBZQxESZmLmaz3gKtA" name="Proximal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R1" isDefault="1" displayUnit="cm">
+                <Parameter id="l7RC-AjiwEa5bRr4sPN7EQ" name="Proximal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R1" isDefault="1" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="yzr7K3O0RE2VKzbNW4FDMg" name="Secretion of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Inflow_LowerIleum" isDefault="1" displayUnit="l/min">
+                <Parameter id="_TtXMUmhi0WPc2MRiKQGVg" name="Secretion of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Inflow_LowerIleum" isDefault="1" displayUnit="l/min">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="jQaUaNZ7wEuy0LDrgRaiTw" name="Distal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R2" isDefault="1" displayUnit="cm">
+                <Parameter id="4yfQTShSqkih3YQIOwRI0A" name="Thickness of gut wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Thickness" isDefault="1" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
+                  <Info min="0" flag="38" seq="1" ref="0" bb="32" group="45" />
+                </Parameter>
+                <Parameter id="EWWBK7VQ10eulDZFhoHc8A" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_LumenSegment" isDefault="1" displayUnit="l">
+                  <Info min="0" flag="62" seq="1" ref="0" bb="2" group="56" />
                 </Parameter>
-                <Parameter id="wWSsppjOOkynfNyAqxsTOw" name="Intestinal transit rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="3.3745" displayUnit="1/min">
+                <Parameter id="suZad3O27EyuUkKKs8zXYg" name="Volume (gut wall)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="MucosaVolume_Human.PARAM_VolumeGutWall_LowerIleum" isDefault="1" displayUnit="l">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="54" seq="1" ref="0" bb="32" group="46" />
+                  <Info min="0" flag="62" seq="1" ref="0" bb="32" group="44" />
+                </Parameter>
+                <Parameter id="LaCbvxox6E2FT-0pp4Wglw" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                  <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                 </Parameter>
-                <Parameter id="DyhNlMRzBUeomvlvwDrBjg" name="Fractional steady state fill level" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.064841">
+                <Parameter id="MZao6qi8nE-mtdVpoMGHYA" name="Fractional steady state fill level" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.064841">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info min="0" flag="58" seq="1" ref="0" bb="32" group="43" />
                 </Parameter>
-                <Parameter id="vso36W7ha0au247Hf489fA" name="Microvilli factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="25">
+                <Parameter id="h2gZetADykeXVEExcRKL6A" name="Intestinal transit rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="3.3745" displayUnit="1/min">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="38" seq="1" ref="0" bb="32" group="33" />
+                  <Info min="0" flag="54" seq="1" ref="0" bb="32" group="46" />
                 </Parameter>
-                <Parameter id="zFPQ28Uw7kWkiyo8zKfn-w" name="Thickness_p1" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0148137399" displayUnit="cm">
+                <Parameter id="V6bkjJtk6UOtI7bvUCzpVA" name="L_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0996435866" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="34" />
                 </Parameter>
-                <Parameter id="ZbUEqamvD0GW7sAKGIOcqQ" name="L_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0996435866" displayUnit="cm">
+                <Parameter id="_8vZcGEOvUmEclPHs1RfdA" name="L_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.445576869">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info flag="54" seq="1" ref="0" bb="32" group="34" />
                 </Parameter>
-                <Parameter id="lUsq_7QZH0eeuBjAYionrA" name="Thickness_p2" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0350288649" displayUnit="cm">
+                <Parameter id="DG6m5OIWiU2jdBN_YrdnaQ" name="Microvilli factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="25">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                  <Info min="0" flag="38" seq="1" ref="0" bb="32" group="33" />
                 </Parameter>
-                <Parameter id="9aHwjK7k20G-p9zRy7m-Gg" name="L_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.445576869">
+                <Parameter id="jL5tbUU0xk6-_qBpK21k2w" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.4583">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="34" />
+                  <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
+                  <Info min="0" max="14" flag="122" seq="1" ref="0" bb="32" group="41" />
                 </Parameter>
-                <Parameter id="axN5u87bt0C4ipOoOyIxmQ" name="r2_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.005786713">
+                <Parameter id="7OJRS0-wwUm4OvcI27-fDA" name="r1_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0015528871" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="w6ZZpLSgZkuA4pVzd42d_w" name="r2_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0012940725" displayUnit="cm">
+                <Parameter id="8NGzZuosy0CY6vfqa2SldQ" name="r1_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.006944055">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="Si0UvNi5pEaza4mlQYa6og" name="r1_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.006944055">
+                <Parameter id="tANs5EwetkmFApuk7R1bgA" name="r2_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0012940725" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="QVFNCl_ET0O-Re8IaR1srg" name="r1_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0015528871" displayUnit="cm">
+                <Parameter id="EdKMW39q8EuoR7fms_wm4Q" name="r2_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.005786713">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="890gF6rIHUukGA3HYlNPpQ" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.4583">
+                <Parameter id="KZUu8CmqgkOZSdZPs2pwmA" name="Thickness_p1" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0148137399" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
-                  <Info min="0" max="14" flag="122" seq="1" ref="0" bb="32" group="41" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                </Parameter>
+                <Parameter id="AUmRaRZBZUaxdwPm5huPqQ" name="Thickness_p2" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0350288649" displayUnit="cm">
+                  <Tags>
+                    <Tag value="Lumen" />
+                    <Tag value="LumenSegment" />
+                  </Tags>
+                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
                 </Parameter>
-                <Parameter id="eGw-PCopeUad9iKgms4ZEg" name="Thickness_p3" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.30705627" displayUnit="1/cm">
+                <Parameter id="-KdjWEzMukq8m9KBthBNaA" name="Thickness_p3" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.30705627" displayUnit="1/cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info flag="54" seq="1" ref="0" bb="32" group="45" />
                 </Parameter>
-                <DistributedParameter id="WgzFobwRoEGrC94zyn2qWg" name="Effective surface area enhancement factor" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ZdGVIsGbaEyfeYkkWJpEqw" mode="Logical" isDefault="1">
+                <DistributedParameter id="Ip--uvokokCbV9YVwuiBdg" name="Effective surface area enhancement factor" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="j3QSx-InBkmt7GZQkch_tQ" mode="Logical" isDefault="1">
                   <Children>
-                    <Parameter id="ETzk7H2XTEmkjAWijfv_lA" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                    <Parameter id="IP_2T-yfj0qXQkLDnbK06g" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
                       <Info min="0" flag="18" seq="1" ref="0" bb="32" group="32" />
                     </Parameter>
-                    <Parameter id="JrCo0klUsEWg-Xxc7tpORA" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="146.565">
+                    <Parameter id="xnGLdkAYQ0-fVf52OLqmEg" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="146.565">
                       <Info min="0" flag="50" seq="1" ref="0" bb="32" group="32" />
                     </Parameter>
                   </Children>
@@ -4657,96 +4689,86 @@
                   </Tags>
                   <Info min="0" flag="122" seq="1" ref="0" bb="32" group="32" />
                 </DistributedParameter>
-                <Container id="OTSDVQunWU2svo5bfonj2A" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="ntE0pJGubkaa-lgkztRRLQ" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                   <Children>
-                    <Parameter id="qWefrv9ENU6hMGbD9096PQ" name="Solubility table" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.TableFormulaWithXArgument_SolubilityTable" isDefault="1" displayUnit="mg/l">
-                      <Info min="0" flag="50" seq="1" ref="0" bb="2" group="42" />
-                    </Parameter>
-                    <Parameter id="_bAKP9dEpEa_NONnRujF1Q" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" isDefault="1">
-                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
-                    </Parameter>
-                    <Parameter id="G-FQ5nDei06V763Zr9T5uQ" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal_GI" isDefault="1">
+                    <Parameter id="8Yy_W3zSW0a96hwyW72jwg" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal_GI" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                     </Parameter>
-                    <Parameter id="E-dLO9kD6kuETY5Qtu1Ckw" name="Oral mass absorbed segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" rHSFormula="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_lil" value="0" displayUnit="µmol">
+                    <Parameter id="KFPQMoaDlkuH4IXjunVUhA" name="Oral mass absorbed segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" rHSFormula="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_lil" value="0" displayUnit="µmol">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                     </Parameter>
-                    <Parameter id="JNtTxUELCEO0frdo5f5Ykg" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
-                      <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                    <Parameter id="0bqHutvZsUePSgp4aJZoiA" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                     </Parameter>
-                    <Parameter id="QIxBLF8sMUyXbwpEJEZxPg" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" isDefault="1">
+                    <Parameter id="St25Hm9wskekfeJHDMnOfA" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="i8YRjlC3Wku4I7t-wJ4Z8w" name="Solubility_pKa_pH_Factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" isDefault="1">
-                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="18" />
+                    <Parameter id="lCQBFNzgL0iiM7-ZiAkxxA" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="SrLZuJMyUUmblQffzPIWPQ" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" isDefault="1">
+                    <Parameter id="5EFgpcGctE-9TNdiCUDjlA" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="IeVs7oOMiU2uXm0T1lz8vw" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" isDefault="1">
+                    <Parameter id="KTFilXfEak22cQ3ZpVdIIg" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="e-31_GOp9UuEdtlNgCLEPA" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" isDefault="1">
+                    <Parameter id="0VxFMfZVG0mgC6PrtPHRmA" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="WAc33Pvi9Eq_UKIowOUeLg" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" isDefault="1">
+                    <Parameter id="PI9h4m5wuUuvAFmhOwsXpw" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="hSPvOhd-EkeljuusXhRvQw" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" isDefault="1">
+                    <Parameter id="DeRXmHavWUeuPu7pYSJTXQ" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="mvIXk-ohE0S4WNweKhFw9w" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" isDefault="1">
+                    <Parameter id="kiEu4b__50GDZUl_pQnvyw" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="b5s-o0giakuK1MVgoM_ugg" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" isDefault="1">
+                    <Parameter id="Xr5SWvWrX0qySkffFniLFQ" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="nVexjv18I0eQ6wuo_SwYLg" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" isDefault="1">
+                    <Parameter id="BtsMp-C4GEOltg3-U7b17Q" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="P_IaybgQw0a7G7Jj4mt8Ow" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" isDefault="1">
+                    <Parameter id="dao-JlfkV0OpRoZGhMHPJQ" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="fophAZT8pU-nbsi64MfQCw" name="Solubility" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_IntestinalSolubility" isDefault="1" displayUnit="mg/l">
+                    <Parameter id="ZcGmORIh_kaR5CNW2nbh0A" name="Solubility" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_IntestinalSolubility" isDefault="1" displayUnit="mg/l">
                       <Info min="0" flag="122" seq="1" ref="0" bb="2" group="42" />
                     </Parameter>
-                    <Parameter id="Ui1LZS7DQEmsmtQ927jR8Q" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
-                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                    <Parameter id="9lRl5BvBc0uPgJg6yUdLng" name="Solubility table" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.TableFormulaWithXArgument_SolubilityTable" isDefault="1" displayUnit="mg/l">
+                      <Info min="0" flag="50" seq="1" ref="0" bb="2" group="42" />
+                    </Parameter>
+                    <Parameter id="SK6sRGthgUqVzS7AwSMRGg" name="Solubility_pKa_pH_Factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" isDefault="1">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="18" />
+                    </Parameter>
+                    <Parameter id="QpQGthQhe0uyHUo7juyylg" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                      <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                    </Parameter>
+                    <Parameter id="_Ikod_Uxbkegk56EyBBl8g" name="Effective concentration in lumen" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_EffectiveLumenConcentration" isDefault="1" displayUnit="µmol/l">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="42" />
                     </Parameter>
                   </Children>
                 </Container>
               </Children>
             </Container>
-            <Container id="1Yph3j4_2EWXIUkeJgtkTg" name="Caecum" mode="Physical" containerType="Compartment">
+            <Container id="kGnbkD3u90iwTRcuuGciQQ" name="Caecum" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="Lumen" />
                 <Tag value="LumenSegment" />
               </Tags>
               <Children>
-                <Parameter id="m5jFO1CSW0ayrfTBkF1Wsg" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
-                  <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
-                </Parameter>
-                <Parameter id="K5K19eXH_kGuzkIkdKgGYA" name="Volume (gut wall)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="MucosaVolume_Human.PARAM_VolumeGutWall_Caecum" isDefault="1" displayUnit="l">
-                  <Tags>
-                    <Tag value="Lumen" />
-                    <Tag value="LumenSegment" />
-                  </Tags>
-                  <Info min="0" flag="62" seq="1" ref="0" bb="32" group="44" />
-                </Parameter>
-                <Parameter id="WiYxlm1YwEO0XQAGpKNf1w" name="Intestinal transit rate (absolute)" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_InverseLITT_Factor_Caecum" isDefault="1" displayUnit="1/min">
-                  <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
-                </Parameter>
-                <Parameter id="7ZQmtmfh3EOypVshbEopTQ" name="Absorption of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Outflow_Caecum" isDefault="1" displayUnit="1/min">
+                <Parameter id="1uBWrv4XCkWjrMjaEOup4Q" name="Absorption of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Outflow_Caecum" isDefault="1" displayUnit="1/min">
                   <Info flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="aShle-Q4d0WvomPU_iw-ZA" name="Distal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R2" isDefault="1" displayUnit="cm">
+                <Parameter id="SPgfHlCm9UOMjBzFUTJMgQ" name="Distal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R2" isDefault="1" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="X-GrekPJiUO4xV5qluDS0A" name="Effective surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_EffectiveSurfaceArea" isDefault="1" displayUnit="cm²">
+                <Parameter id="H01m3SIS4ES1n7mCDWUFIw" name="Effective surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_EffectiveSurfaceArea" isDefault="1" displayUnit="cm²">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
@@ -4754,137 +4776,150 @@
                   <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
                   <Info min="0" flag="52" seq="1" ref="0" bb="32" group="33" />
                 </Parameter>
-                <Parameter id="JY1v7xVv6EeYFDw0EMRGjw" name="FillLevelFlag" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevelFlagFlag" isDefault="1">
+                <Parameter id="J2wniej1TU22uSjYghfYzg" name="FillLevelFlag" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevelFlagFlag" isDefault="1">
+                  <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                </Parameter>
+                <Parameter id="kKXz2DInkUG6RSoG4S9i6A" name="Fraction of geometric volume filled with liquid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevel" isDefault="1">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="Bfps-3P-8ki8eyzt4wH_hQ" name="Geometric surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Area" isDefault="1" displayUnit="cm²">
+                <Parameter id="QqGXS-m6_UeWnjzruyxlPg" name="Geometric surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Area" isDefault="1" displayUnit="cm²">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info min="0" flag="62" seq="1" ref="0" bb="32" group="33" />
                 </Parameter>
-                <Parameter id="wGgOSw-I1Ui5G4IxSUmCsQ" name="Length" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Length" isDefault="1" displayUnit="cm">
+                <Parameter id="NIFlwNuhykW1kyZC_Cd0Sw" name="Intestinal transit rate (absolute)" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_InverseLITT_Factor_Caecum" isDefault="1" displayUnit="1/min">
+                  <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                </Parameter>
+                <Parameter id="DNpvmymw9UqINaHw0ISnRg" name="Length" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Length" isDefault="1" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info min="0" flag="106" seq="1" ref="0" bb="32" group="34" />
                 </Parameter>
-                <Parameter id="vv2aHYdCBkq5sF-q8byqnw" name="Liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Liquid_StartValue" isDefault="1" rHSFormula="Lumen_PKSim.LiquidRHS_cae" displayUnit="l">
+                <Parameter id="bd9uQ6e6Z0-Ox2HAuEBEcw" name="Liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Liquid_StartValue" isDefault="1" rHSFormula="Lumen_PKSim.LiquidRHS_cae" displayUnit="l">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="a5LUc7wrmkCnhHHYEeIVSA" name="Liquid transfer rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_LiquidTransferRate_cae" isDefault="1" displayUnit="l/min">
+                <Parameter id="D9mKbqJXFk2M9lDtltc-AA" name="Liquid transfer rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_LiquidTransferRate_cae" isDefault="1" displayUnit="l/min">
                   <Info flag="52" seq="1" ref="0" bb="2" group="39" />
                 </Parameter>
-                <Parameter id="mZCPT0qq30Ss1Og-Dlcxmg" name="Proximal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R1" isDefault="1" displayUnit="cm">
+                <Parameter id="5SJVi7ArwE67b7QdqswfUw" name="Proximal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R1" isDefault="1" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="ErbFhXLNXUWAY0LGJlbkbg" name="Secretion of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Inflow_Caecum" isDefault="1" displayUnit="l/min">
+                <Parameter id="_E8nwXklzEaZ3wI-9QnzyA" name="Secretion of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Inflow_Caecum" isDefault="1" displayUnit="l/min">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="rF_wPA2IlU6K9EmD1rEJ3A" name="Thickness of gut wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Thickness" isDefault="1" displayUnit="cm">
+                <Parameter id="WBsyUwkA6EC_dypEglCO4Q" name="Thickness of gut wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Thickness" isDefault="1" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info min="0" flag="38" seq="1" ref="0" bb="32" group="45" />
                 </Parameter>
-                <Parameter id="LenYnmW7okewHWAQsE3vTw" name="Fraction of geometric volume filled with liquid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevel" isDefault="1">
-                  <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
-                </Parameter>
-                <Parameter id="jN_0h5OTZEGl5Z54jL1PDg" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_LumenSegment" isDefault="1" displayUnit="l">
+                <Parameter id="4j40rJRIPUm8dwqbbAzmIA" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_LumenSegment" isDefault="1" displayUnit="l">
                   <Info min="0" flag="62" seq="1" ref="0" bb="2" group="56" />
                 </Parameter>
-                <Parameter id="PA6o8Tr64E2G18ynvfRtCg" name="r1_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.015672726">
+                <Parameter id="_hQJ1P4eR0yQtg6Udphleg" name="Volume (gut wall)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="MucosaVolume_Human.PARAM_VolumeGutWall_Caecum" isDefault="1" displayUnit="l">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                  <Info min="0" flag="62" seq="1" ref="0" bb="32" group="44" />
+                </Parameter>
+                <Parameter id="H2oA0B4uKk-TIcOT468_lg" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                  <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                 </Parameter>
-                <Parameter id="kL2h6hYjTUWOWtTQ7tBC7w" name="Thickness_p3" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0897885" displayUnit="1/cm">
+                <Parameter id="lSQ-JcT4kUi3eVurcn8KVQ" name="Fractional steady state fill level" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0060009">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                  <Info min="0" flag="58" seq="1" ref="0" bb="32" group="43" />
                 </Parameter>
-                <Parameter id="ustytvQpLkuLZrR2sSxfqw" name="Thickness_p2" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0446435379" displayUnit="cm">
+                <Parameter id="12-U1vxg2UaSX7Fp_iYzTw" name="Intestinal transit rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="18.3333" displayUnit="1/min">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                  <Info min="0" flag="54" seq="1" ref="0" bb="32" group="46" />
                 </Parameter>
-                <Parameter id="SSLilgmW9kibDt-JhnHaHA" name="Thickness_p1" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.00877" displayUnit="cm">
+                <Parameter id="8uSG16I94kKOJYRNxDM0Dw" name="L_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.1152851235" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="34" />
                 </Parameter>
-                <Parameter id="dNgbSTqnskS5YUfFGxqeBA" name="r2_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.015672726">
+                <Parameter id="VtOy-WtLHkWteBmsWc7ejQ" name="L_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.026864843">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="34" />
+                </Parameter>
+                <Parameter id="3zUFQa0L7k-OVhCZu9xDfA" name="Microvilli factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                  <Tags>
+                    <Tag value="Lumen" />
+                    <Tag value="LumenSegment" />
+                  </Tags>
+                  <Info min="0" flag="38" seq="1" ref="0" bb="32" group="33" />
                 </Parameter>
-                <Parameter id="54woVcP-LkCcWahgU1jSPA" name="r1_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.067256381" displayUnit="cm">
+                <Parameter id="7pHaHczxAUa6QhU2Iz6xxw" name="r1_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.067256381" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="J-QvFOY0TUOJSlPKRUk3ZA" name="r2_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.067256381" displayUnit="cm">
+                <Parameter id="BpuleUEvpkyxG5rQS-80vA" name="r1_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.015672726">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="oy0jWqLH9EukJ_fa8dv8Iw" name="Microvilli factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                <Parameter id="JsjQNCOm4UqcBIGGDUaXng" name="r2_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.067256381" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="38" seq="1" ref="0" bb="32" group="33" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="cnbWv39XkUOO-GSVB9S81w" name="L_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.026864843">
+                <Parameter id="wc2565ibTEOtvF9TJf04SA" name="r2_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.015672726">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="34" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="fDk8nzQxy0-ZKeqGIiNn6Q" name="L_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.1152851235" displayUnit="cm">
+                <Parameter id="8vOMBKn3mEOdfehS5aadBQ" name="Thickness_p1" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.00877" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="34" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
                 </Parameter>
-                <Parameter id="Ttf8CaR8S0ix4TAkZp0_zQ" name="Intestinal transit rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="18.3333" displayUnit="1/min">
+                <Parameter id="GPSUgAibU0mI3mnbQRMi9g" name="Thickness_p2" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0446435379" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="54" seq="1" ref="0" bb="32" group="46" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
                 </Parameter>
-                <Parameter id="7tKN96KBGUO_rjWWCvqs6g" name="Fractional steady state fill level" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0060009">
+                <Parameter id="M3dBzyarO0Os09nvQ4tGkQ" name="Thickness_p3" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0897885" displayUnit="1/cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="58" seq="1" ref="0" bb="32" group="43" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
                 </Parameter>
-                <Parameter id="h85nupwth0G6F3usU7UEvg" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="5.7">
+                <Parameter id="Cuig-MEn706ZmCB4_-lpaQ" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="5.7">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
@@ -4892,12 +4927,12 @@
                   <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
                   <Info min="0" max="14" flag="122" seq="1" ref="0" bb="32" group="41" />
                 </Parameter>
-                <DistributedParameter id="Flg-25fzy0GkPjD7Gb2tFg" name="Effective surface area enhancement factor" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="9MaLxqWDYE6-nkPzxnpfXA" mode="Logical" isDefault="1">
+                <DistributedParameter id="gJwfdLEsfE-1vZwyM7wYdQ" name="Effective surface area enhancement factor" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="NxvRSvOjLkGZdCbVs0IR5w" mode="Logical" isDefault="1">
                   <Children>
-                    <Parameter id="m0UDz5gM2ESVRYIy0EqD7A" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                    <Parameter id="ffUcAXDwPEeyqFp-HEWLCw" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
                       <Info min="0" flag="18" seq="1" ref="0" bb="32" group="32" />
                     </Parameter>
-                    <Parameter id="eBPvpMYk9k6cZdGCcjxZNA" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.8">
+                    <Parameter id="w5i0hq5GY0SxPwIvj_uKqA" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.8">
                       <Info min="0" flag="50" seq="1" ref="0" bb="32" group="32" />
                     </Parameter>
                   </Children>
@@ -4907,96 +4942,86 @@
                   </Tags>
                   <Info min="0" flag="122" seq="1" ref="0" bb="32" group="32" />
                 </DistributedParameter>
-                <Container id="zumV-8wdMUi2VTU8q-Hj8g" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="dAN7_5SWi0KWqBYx-oA7Pw" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                   <Children>
-                    <Parameter id="2Z9_KHwlYEqhTc8AfQgcRQ" name="Oral mass absorbed segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" rHSFormula="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_cae" value="0" displayUnit="µmol">
-                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                    <Parameter id="AAIWkF57J0aNpTSXvTdVNw" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal_GI" isDefault="1">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                     </Parameter>
-                    <Parameter id="Q_fyfWDVhkCgfkZe9u8Tug" name="Solubility" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_IntestinalSolubility" isDefault="1" displayUnit="mg/l">
-                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="42" />
+                    <Parameter id="9klPOXLVDEyBQg3jGh-bPQ" name="Oral mass absorbed segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" rHSFormula="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_cae" value="0" displayUnit="µmol">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                     </Parameter>
-                    <Parameter id="rprs1PO4akm-pcqpgnyRiw" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                    <Parameter id="4IjZ-WpMwU23q9erONlL8g" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                     </Parameter>
-                    <Parameter id="GedrnHNXzkqDogbMCJ70lA" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" isDefault="1">
+                    <Parameter id="jshcocMfcEuzePBtMQzGWA" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="h_u8EE9xA0SDO6jBLSZwWg" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" isDefault="1">
+                    <Parameter id="Lw2pEliLCk-N667d_gvU5Q" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="OTEegKRFqUSpJDdoE_SKsw" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" isDefault="1">
+                    <Parameter id="9jdG1w9QrUuNzoaD2JqxdA" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="OXf08tUGBUyCI4jWwqWIHA" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" isDefault="1">
+                    <Parameter id="BLTcjHF5JEGqoq6XiqmDGw" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="YKh6UE8UX0yeaibByMt5bg" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" isDefault="1">
+                    <Parameter id="OcIkOYIB_kCZMIFNybKGqg" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="DPEsaEGbAUaPhH0YAxT7Ow" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" isDefault="1">
+                    <Parameter id="gG4UJQPPVEayImESSJX_7g" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="WWQf3eeU60u8EZKOayAeGg" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" isDefault="1">
+                    <Parameter id="IvWslde7pkyrzmDulNDV1Q" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="xk6tYVJYukqC2r-D4KpD1w" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" isDefault="1">
+                    <Parameter id="Da7RqvJUZkq91fLd2JZRqw" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="circP_7Rdku6fmeObhgjlQ" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" isDefault="1">
+                    <Parameter id="Ns6Xu7k6U0i_HyYksVHcAw" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="coshPeMseEyaeRd8IgtTIA" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" isDefault="1">
+                    <Parameter id="oGOBWzHkpkGCFb8fuE_2sw" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="-Zuz_XzdWUqvDFYsrRg_ew" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal_GI" isDefault="1">
-                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                    <Parameter id="eCsAy0zhZEyfMm7tMa8maw" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                    </Parameter>
+                    <Parameter id="QTgvErcuWU-RkyKJxeERhw" name="Solubility" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_IntestinalSolubility" isDefault="1" displayUnit="mg/l">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="42" />
                     </Parameter>
-                    <Parameter id="ZQ5Lf5PnFEKzUdo32h2Yzg" name="Solubility table" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.TableFormulaWithXArgument_SolubilityTable" isDefault="1" displayUnit="mg/l">
+                    <Parameter id="JM8iD4j3eUuhRnLHwtgzxg" name="Solubility table" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.TableFormulaWithXArgument_SolubilityTable" isDefault="1" displayUnit="mg/l">
                       <Info min="0" flag="50" seq="1" ref="0" bb="2" group="42" />
                     </Parameter>
-                    <Parameter id="rogf2SN4OU2BmFykdXSJiA" name="Solubility_pKa_pH_Factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" isDefault="1">
+                    <Parameter id="xNFAXEH0_EOLcZvskiQf3A" name="Solubility_pKa_pH_Factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="KjUp5eMeMkihINPqp4Oedg" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                    <Parameter id="dyhR06sHREiDXvFpzdfZfQ" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
                       <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                     </Parameter>
-                    <Parameter id="ZVTjLWrR5Uabc9gLNvHXCA" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" isDefault="1">
-                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                    <Parameter id="yb8mhzN3JUqzh7D__M5JiA" name="Effective concentration in lumen" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_EffectiveLumenConcentration" isDefault="1" displayUnit="µmol/l">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="42" />
                     </Parameter>
                   </Children>
                 </Container>
               </Children>
             </Container>
-            <Container id="ATNjWx7V7keoPmoUq2XmTQ" name="ColonAscendens" mode="Physical" containerType="Compartment">
+            <Container id="B6U75mASo02V01eMygYROA" name="ColonAscendens" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="Lumen" />
                 <Tag value="LumenSegment" />
               </Tags>
               <Children>
-                <Parameter id="Pv9ZQdK9wU-xSfHR8xplJg" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
-                  <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
-                </Parameter>
-                <Parameter id="lqUekdxs2kGKlPG1dBEttw" name="Volume (gut wall)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="MucosaVolume_Human.PARAM_VolumeGutWall_ColonAscendens" isDefault="1" displayUnit="l">
-                  <Tags>
-                    <Tag value="Lumen" />
-                    <Tag value="LumenSegment" />
-                  </Tags>
-                  <Info min="0" flag="62" seq="1" ref="0" bb="32" group="44" />
-                </Parameter>
-                <Parameter id="EVXPB6Qg9Eye3LrZiAXrCA" name="Liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Liquid_StartValue" isDefault="1" rHSFormula="Lumen_PKSim.LiquidRHS_colasc" displayUnit="l">
-                  <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
-                </Parameter>
-                <Parameter id="CSb-GeLLeUa6a4S9RSmlyw" name="Absorption of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Outflow_ColonAscendens" isDefault="1" displayUnit="1/min">
+                <Parameter id="Fj9N-9OqZUirLkOYcOjW4w" name="Absorption of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Outflow_ColonAscendens" isDefault="1" displayUnit="1/min">
                   <Info flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="WnkhUNhqNU2qxbeEi3lRHA" name="Distal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R2" isDefault="1" displayUnit="cm">
+                <Parameter id="JTLznwgDPkmPtJEuBuxFHA" name="Distal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R2" isDefault="1" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="IUWb7jdLgUyCmEDBbvOmig" name="Effective surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_EffectiveSurfaceArea" isDefault="1" displayUnit="cm²">
+                <Parameter id="NnjMLsHaZ0urVtFOxTeL2Q" name="Effective surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_EffectiveSurfaceArea" isDefault="1" displayUnit="cm²">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
@@ -5004,150 +5029,163 @@
                   <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
                   <Info min="0" flag="52" seq="1" ref="0" bb="32" group="33" />
                 </Parameter>
-                <Parameter id="DHD-7kmNS0iup-_inhTGHA" name="FillLevelFlag" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevelFlagFlag" isDefault="1">
+                <Parameter id="R9YHUK8rVEW4qICSVB0vXA" name="FillLevelFlag" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevelFlagFlag" isDefault="1">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="YJgyftLhDEetll1m0svdnQ" name="Fraction of geometric volume filled with liquid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevel" isDefault="1">
+                <Parameter id="Jf2ZY5QtM0eoGMlsy0sKNw" name="Fraction of geometric volume filled with liquid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevel" isDefault="1">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="a2viiyMH40iN-BnZr5xvnw" name="Geometric surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Area" isDefault="1" displayUnit="cm²">
+                <Parameter id="jON1VrWHLE2Im5Dke-VhTQ" name="Geometric surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Area" isDefault="1" displayUnit="cm²">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info min="0" flag="62" seq="1" ref="0" bb="32" group="33" />
                 </Parameter>
-                <Parameter id="MtnWOBSokUqS7BCkwQUmJA" name="Length" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Length" isDefault="1" displayUnit="cm">
+                <Parameter id="aqpSScu0i0GXfIF6on_oHA" name="Intestinal transit rate (absolute)" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_InverseLITT_Factor_ColonAscendens" isDefault="1" displayUnit="1/min">
+                  <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                </Parameter>
+                <Parameter id="X_xSVDBN_0meFTEfB40v1w" name="Length" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Length" isDefault="1" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info min="0" flag="106" seq="1" ref="0" bb="32" group="34" />
                 </Parameter>
-                <Parameter id="ngyB39MUDEyWPWV0A9ANKw" name="Liquid transfer rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_LiquidTransferRate_colasc" isDefault="1" displayUnit="l/min">
+                <Parameter id="ANPAHsHenUankFwh5DMfAg" name="Liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Liquid_StartValue" isDefault="1" rHSFormula="Lumen_PKSim.LiquidRHS_colasc" displayUnit="l">
+                  <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                </Parameter>
+                <Parameter id="Jmzl8kobsky6ZxUrBJBlpw" name="Liquid transfer rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_LiquidTransferRate_colasc" isDefault="1" displayUnit="l/min">
                   <Info flag="52" seq="1" ref="0" bb="2" group="39" />
                 </Parameter>
-                <Parameter id="EkNGv2BMQ0eS4BDCylonQA" name="Proximal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R1" isDefault="1" displayUnit="cm">
+                <Parameter id="OTyPzMslgEyrUOC0AtJJWw" name="Proximal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R1" isDefault="1" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="PQtgzeKyykOU_zPVXUZD_A" name="Secretion of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Inflow_ColonAscendens" isDefault="1" displayUnit="l/min">
+                <Parameter id="-g-ZtRitB0uz1Im4wYYPtQ" name="Secretion of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Inflow_ColonAscendens" isDefault="1" displayUnit="l/min">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="mo-xDhVBEUqLcqJ5KkcPZQ" name="Thickness of gut wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Thickness" isDefault="1" displayUnit="cm">
+                <Parameter id="Ml63R9PiukWW_2VuV1n_BQ" name="Thickness of gut wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Thickness" isDefault="1" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info min="0" flag="38" seq="1" ref="0" bb="32" group="45" />
                 </Parameter>
-                <Parameter id="hvfXBUYUyk6jEnNq_JPNFw" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_LumenSegment" isDefault="1" displayUnit="l">
+                <Parameter id="b3dkRiLc4keotDyQpMVbSg" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_LumenSegment" isDefault="1" displayUnit="l">
                   <Info min="0" flag="62" seq="1" ref="0" bb="2" group="56" />
                 </Parameter>
-                <Parameter id="A13mdWSRsUuk4lA0mAFOuQ" name="Intestinal transit rate (absolute)" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_InverseLITT_Factor_ColonAscendens" isDefault="1" displayUnit="1/min">
-                  <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                <Parameter id="Uho_gd33eUGheQ-qDvGFug" name="Volume (gut wall)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="MucosaVolume_Human.PARAM_VolumeGutWall_ColonAscendens" isDefault="1" displayUnit="l">
+                  <Tags>
+                    <Tag value="Lumen" />
+                    <Tag value="LumenSegment" />
+                  </Tags>
+                  <Info min="0" flag="62" seq="1" ref="0" bb="32" group="44" />
+                </Parameter>
+                <Parameter id="8dhtxUXzpEOEVsz7YQgCWA" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                  <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                 </Parameter>
-                <Parameter id="UDOIiCyQS0-zLLZ7e3l-SQ" name="Fractional steady state fill level" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0060009">
+                <Parameter id="15yQE_o2s0ifsMov-aTmtw" name="Fractional steady state fill level" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0060009">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info min="0" flag="58" seq="1" ref="0" bb="32" group="43" />
                 </Parameter>
-                <Parameter id="xySlnb84NEmzBkkAK5X0eg" name="r1_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.015672726">
+                <Parameter id="IuaXOaMoZkqKfGawNYJ4hg" name="Intestinal transit rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="1/min">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                  <Info min="0" flag="54" seq="1" ref="0" bb="32" group="46" />
                 </Parameter>
-                <Parameter id="oJXj8_DVHUe-ZmojlCvB4w" name="r1_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.067256381" displayUnit="cm">
+                <Parameter id="gLqbADwZUU24g2o76n4r8w" name="L_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.3117189273" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="34" />
                 </Parameter>
-                <Parameter id="poAZBJJ5006ntoei2AYEgg" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="5.6">
+                <Parameter id="-S2Tpdd11kqKpc_zgfn0_g" name="L_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.075727844">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
-                  <Info min="0" max="14" flag="122" seq="1" ref="0" bb="32" group="41" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="34" />
                 </Parameter>
-                <Parameter id="G1IGLklNa0WRz75-OSbp2A" name="Microvilli factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                <Parameter id="-W0Q2zLct0i71fDJLduF1A" name="Microvilli factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info min="0" flag="38" seq="1" ref="0" bb="32" group="33" />
                 </Parameter>
-                <Parameter id="KA_2Y0JR6UioNkbPC8PNWA" name="L_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.075727844">
+                <Parameter id="JTU8ySdzW0alWrpXQIn9zw" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="5.6">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="34" />
+                  <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
+                  <Info min="0" max="14" flag="122" seq="1" ref="0" bb="32" group="41" />
                 </Parameter>
-                <Parameter id="Qg7zhxjx6UywaPfiHD6vKw" name="r2_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.015672726">
+                <Parameter id="exammPQEXUmC9milO1dTag" name="r1_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.067256381" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="mrONPoGr30GebfsZjOuhtA" name="Intestinal transit rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="1/min">
+                <Parameter id="AZp-m4mbikuf0WowZSUsVA" name="r1_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.015672726">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="54" seq="1" ref="0" bb="32" group="46" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="NtDVIR8knE2pVLOa0lrHcw" name="Thickness_p1" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.00554" displayUnit="cm">
+                <Parameter id="GBjtBr7EhkapDFiRFnYQOg" name="r2_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.067256381" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="5h1-pjIlP0WqQMfhvOjKlg" name="L_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.3117189273" displayUnit="cm">
+                <Parameter id="JdDBkwpCv0KbLc6HzaimRw" name="r2_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.015672726">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="34" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="4ghmzT2vAEK81k-OL5lDng" name="r2_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.067256381" displayUnit="cm">
+                <Parameter id="SlKsccJk8kaL5_N3gnx4Dg" name="Thickness_p1" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.00554" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
                 </Parameter>
-                <Parameter id="P_MoBMD-A0aLxBMT4Z1qww" name="Thickness_p3" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.09106073" displayUnit="1/cm">
+                <Parameter id="TeXXljrgl0aMRobuWzCeQw" name="Thickness_p2" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0280138174" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info flag="54" seq="1" ref="0" bb="32" group="45" />
                 </Parameter>
-                <Parameter id="7SunJyk7G0OX2KXObYl3Bw" name="Thickness_p2" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0280138174" displayUnit="cm">
+                <Parameter id="-u5_jUaN9UKfmmTrqHR2kw" name="Thickness_p3" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.09106073" displayUnit="1/cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info flag="54" seq="1" ref="0" bb="32" group="45" />
                 </Parameter>
-                <DistributedParameter id="zjhc7gKuRkWqAtUMmvWomw" name="Effective surface area enhancement factor" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CKZJjJgDk0-mNVwVMQmD0g" mode="Logical" isDefault="1">
+                <DistributedParameter id="x6HNEgEBREyh0BOzdVZJ3Q" name="Effective surface area enhancement factor" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="nyFtcjmGZ0qdmHF8bQV8nA" mode="Logical" isDefault="1">
                   <Children>
-                    <Parameter id="mRq4PntBQE2GVfqKv5iTEA" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                    <Parameter id="99bX8dZ3hEOFdGeDSbyw8Q" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
                       <Info min="0" flag="18" seq="1" ref="0" bb="32" group="32" />
                     </Parameter>
-                    <Parameter id="aNp1q0s1qE2RQGfU9U-aQA" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.5">
+                    <Parameter id="F0TrGVR58EWRbqQqP5LPFg" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.5">
                       <Info min="0" flag="50" seq="1" ref="0" bb="32" group="32" />
                     </Parameter>
                   </Children>
@@ -5157,87 +5195,86 @@
                   </Tags>
                   <Info min="0" flag="122" seq="1" ref="0" bb="32" group="32" />
                 </DistributedParameter>
-                <Container id="SBK1e6bdQEyIVWWo_nWCgQ" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="2CRjg6lz4Eae-6ejLP8JAA" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                   <Children>
-                    <Parameter id="Mah9dA56m06cTAUNoMGERw" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" isDefault="1">
-                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                    <Parameter id="B7d32wW7vUSE4XHlIw-KCg" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal_GI" isDefault="1">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                     </Parameter>
-                    <Parameter id="pToM1Uwm5ECMa8L2gWCMxg" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" isDefault="1">
-                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
-                    </Parameter>
-                    <Parameter id="x9Y8kRfH0UCg_N6cGFyESA" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" isDefault="1">
-                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
-                    </Parameter>
-                    <Parameter id="FNvtXaJiAkOQRlU1QXzNUQ" name="Solubility" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_IntestinalSolubility" isDefault="1" displayUnit="mg/l">
-                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="42" />
-                    </Parameter>
-                    <Parameter id="frF0AKiLVEe0YRFrbwD3EA" name="Solubility table" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.TableFormulaWithXArgument_SolubilityTable" isDefault="1" displayUnit="mg/l">
-                      <Info min="0" flag="50" seq="1" ref="0" bb="2" group="42" />
-                    </Parameter>
-                    <Parameter id="qb_7175IjEi10yeBEcu-KA" name="Solubility_pKa_pH_Factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" isDefault="1">
-                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="18" />
+                    <Parameter id="tgyo2EQGdkKd1_W-HpeWVQ" name="Oral mass absorbed segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" rHSFormula="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_colasc" value="0" displayUnit="µmol">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                     </Parameter>
-                    <Parameter id="1pKbrUMb_kCt9wvWXGR-aQ" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
-                      <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                    <Parameter id="kB79xK0Sckq91vBoPGQUZA" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                     </Parameter>
-                    <Parameter id="0UFnWe_8-kChdD2SwT8i7w" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" isDefault="1">
+                    <Parameter id="-rIJbQkggkGpUY4yg5eTww" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="ffGB3yvGgEStf6ys52ye0Q" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" isDefault="1">
+                    <Parameter id="V0_1RwNotEKtKGc-ERT39g" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="0Te8qpydjU-vJ0pG7EVdHA" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" isDefault="1">
+                    <Parameter id="NsmucozdEUWLwnlBrbHStQ" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="cjc2S7gerUKGRgqKTHOS8w" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal_GI" isDefault="1">
-                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                    <Parameter id="6A2m_2FQc0-X0arK8hz9wA" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="Y6OiQqNeHUCLi5NGB8IKUg" name="Oral mass absorbed segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" rHSFormula="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_colasc" value="0" displayUnit="µmol">
-                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                    <Parameter id="HnCMGn1uHU23aAjTF2JPvQ" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="6CQ_6M2h7k2tduj9JzemtA" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
-                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                    <Parameter id="kx06K8IDvE-wj1FzqyMe3w" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="3qUHBFMdPUyKivmCWIyaww" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" isDefault="1">
+                    <Parameter id="RnU6_ud2K0-lAJyJKllOLQ" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="VhAsSCyZqkClOwuOVm95Lg" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" isDefault="1">
+                    <Parameter id="5ljbULukpUSz0HE3pVIvRw" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="0QH2c7zdcU-qSY2_VP796w" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" isDefault="1">
+                    <Parameter id="JCpbNwBTmE6XufnLox4wFA" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="SthHmwe52km-2MnmrcV4Hw" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" isDefault="1">
+                    <Parameter id="wrKbcNdY7EGXD26LDQY03A" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="TLddyaRsmUmfiqpN7Zl0bA" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" isDefault="1">
+                    <Parameter id="xkOvyCXkSESwuWSwu1nADw" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
+                    <Parameter id="mhKq-2vO00OGPRpOpy3QyA" name="Solubility" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_IntestinalSolubility" isDefault="1" displayUnit="mg/l">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="42" />
+                    </Parameter>
+                    <Parameter id="dXDN054kFUqcYAayz3H9vg" name="Solubility table" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.TableFormulaWithXArgument_SolubilityTable" isDefault="1" displayUnit="mg/l">
+                      <Info min="0" flag="50" seq="1" ref="0" bb="2" group="42" />
+                    </Parameter>
+                    <Parameter id="8VBCHpNoZE-q7qLlpe21vA" name="Solubility_pKa_pH_Factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" isDefault="1">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="18" />
+                    </Parameter>
+                    <Parameter id="MIdTy6jkbEG3MjjyQK_xcg" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                      <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                    </Parameter>
+                    <Parameter id="7LHGI3JbVE2ObdCrCUdj0w" name="Effective concentration in lumen" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_EffectiveLumenConcentration" isDefault="1" displayUnit="µmol/l">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="42" />
+                    </Parameter>
                   </Children>
                 </Container>
               </Children>
             </Container>
-            <Container id="ulKpUIAAi06wltlr56erzQ" name="ColonTransversum" mode="Physical" containerType="Compartment">
+            <Container id="azrzt6ezxUOsH5qwRQFgow" name="ColonTransversum" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="Lumen" />
                 <Tag value="LumenSegment" />
               </Tags>
               <Children>
-                <Parameter id="Z8fDtzXy7UqfUQTum30hkw" name="Proximal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R1" isDefault="1" displayUnit="cm">
-                  <Tags>
-                    <Tag value="Lumen" />
-                    <Tag value="LumenSegment" />
-                  </Tags>
-                  <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
+                <Parameter id="OLi33m6kF0KK27RpMlkiFQ" name="Absorption of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Outflow_ColonTransversum" isDefault="1" displayUnit="1/min">
+                  <Info flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="yQYoPD1FOUagH_Jtbh4RGw" name="Distal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R2" isDefault="1" displayUnit="cm">
+                <Parameter id="ivDx_GLhZUGKxitwU2GjbQ" name="Distal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R2" isDefault="1" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="PbixDA6h1UOgi58El83fcg" name="Effective surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_EffectiveSurfaceArea" isDefault="1" displayUnit="cm²">
+                <Parameter id="d2KxpSS_RECAhHVIz-UGgA" name="Effective surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_EffectiveSurfaceArea" isDefault="1" displayUnit="cm²">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
@@ -5245,159 +5282,163 @@
                   <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
                   <Info min="0" flag="52" seq="1" ref="0" bb="32" group="33" />
                 </Parameter>
-                <Parameter id="ncnejcBudkqOo8TkFQ5lNg" name="FillLevelFlag" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevelFlagFlag" isDefault="1">
+                <Parameter id="bWDwKaMIVkmFOLs3hFdyTg" name="FillLevelFlag" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevelFlagFlag" isDefault="1">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="Mbe-589VDkeLuUaZVGXkGw" name="Fraction of geometric volume filled with liquid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevel" isDefault="1">
+                <Parameter id="Ft5JnClWpEOEP6gKbwlwuA" name="Fraction of geometric volume filled with liquid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevel" isDefault="1">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="bxtctqO4AUi2qB5x9PXdaw" name="Geometric surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Area" isDefault="1" displayUnit="cm²">
+                <Parameter id="wfbFzDn43k62aAVXs74t9Q" name="Geometric surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Area" isDefault="1" displayUnit="cm²">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info min="0" flag="62" seq="1" ref="0" bb="32" group="33" />
                 </Parameter>
-                <Parameter id="WRqZI42120q3hYlPq2c9og" name="Intestinal transit rate (absolute)" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_InverseLITT_Factor_ColonTransversum" isDefault="1" displayUnit="1/min">
+                <Parameter id="YKLexjuaZkamuhcajbEGSg" name="Intestinal transit rate (absolute)" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_InverseLITT_Factor_ColonTransversum" isDefault="1" displayUnit="1/min">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="p05yXCJX-0qE4VSH5Q93Fg" name="Length" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Length" isDefault="1" displayUnit="cm">
+                <Parameter id="yKOBfraEFEaCvDrWAbgPZg" name="Length" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Length" isDefault="1" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info min="0" flag="106" seq="1" ref="0" bb="32" group="34" />
                 </Parameter>
-                <Parameter id="SbrIJHKFYk-xH-CqfDbaoA" name="Liquid transfer rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_LiquidTransferRate_coltrans" isDefault="1" displayUnit="l/min">
+                <Parameter id="GvXWW5RlhkyWUDbLr_wCUQ" name="Liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Liquid_StartValue" isDefault="1" rHSFormula="Lumen_PKSim.LiquidRHS_coltrans" displayUnit="l">
+                  <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                </Parameter>
+                <Parameter id="G6hfr8kZmk-ZuVvP8EKaiA" name="Liquid transfer rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_LiquidTransferRate_coltrans" isDefault="1" displayUnit="l/min">
                   <Info flag="52" seq="1" ref="0" bb="2" group="39" />
                 </Parameter>
-                <Parameter id="6cG3-1F6iU-t1pGEIDUpGQ" name="Secretion of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Inflow_ColonTransversum" isDefault="1" displayUnit="l/min">
+                <Parameter id="dygviq8P2EmEZwAT1g4IBw" name="Proximal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R1" isDefault="1" displayUnit="cm">
+                  <Tags>
+                    <Tag value="Lumen" />
+                    <Tag value="LumenSegment" />
+                  </Tags>
+                  <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
+                </Parameter>
+                <Parameter id="GQaoZwZNyEKm9Wp1hbooLQ" name="Secretion of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Inflow_ColonTransversum" isDefault="1" displayUnit="l/min">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="-l7ttuK5dUiJpiJTJdLRug" name="Thickness of gut wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Thickness" isDefault="1" displayUnit="cm">
+                <Parameter id="6P__CHyeWUK74uZOt6U0xQ" name="Thickness of gut wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Thickness" isDefault="1" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info min="0" flag="38" seq="1" ref="0" bb="32" group="45" />
                 </Parameter>
-                <Parameter id="T4vFzhYjwUeGxv7ZfyT4FA" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_LumenSegment" isDefault="1" displayUnit="l">
+                <Parameter id="SoN1GbHmTU6ZMYeRSk0Kgw" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_LumenSegment" isDefault="1" displayUnit="l">
                   <Info min="0" flag="62" seq="1" ref="0" bb="2" group="56" />
                 </Parameter>
-                <Parameter id="FKlMKzXYo06qEggy-CGJSg" name="Volume (gut wall)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="MucosaVolume_Human.PARAM_VolumeGutWall_ColonTransversum" isDefault="1" displayUnit="l">
+                <Parameter id="4ze6YHGBDEWbB4fx0801dQ" name="Volume (gut wall)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="MucosaVolume_Human.PARAM_VolumeGutWall_ColonTransversum" isDefault="1" displayUnit="l">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info min="0" flag="62" seq="1" ref="0" bb="32" group="44" />
                 </Parameter>
-                <Parameter id="eCw4hiTaqUOKSdldl9rptw" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                <Parameter id="-YKOyD3CwU6PUIDFgPopDw" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
                   <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                 </Parameter>
-                <Parameter id="S4SngO2dxEmWuTMQ8Z_ZEw" name="Liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Liquid_StartValue" isDefault="1" rHSFormula="Lumen_PKSim.LiquidRHS_coltrans" displayUnit="l">
-                  <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
-                </Parameter>
-                <Parameter id="tjNVaWv9YkWbTiw95tLcLw" name="Absorption of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Outflow_ColonTransversum" isDefault="1" displayUnit="1/min">
-                  <Info flag="54" seq="1" ref="0" bb="2" group="63" />
-                </Parameter>
-                <Parameter id="A4GjWMvmtkiX5yn1hPwHRw" name="Thickness_p2" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0394956146" displayUnit="cm">
+                <Parameter id="1Fhs1rRsyUm3hyBuoBeTAg" name="Fractional steady state fill level" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0060009">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                  <Info min="0" flag="58" seq="1" ref="0" bb="32" group="43" />
                 </Parameter>
-                <Parameter id="JZdjogbiK0qQ-ydhgDwuNQ" name="L_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.144607745">
+                <Parameter id="onrFxiK_oE-FOccZm4CMAA" name="Intestinal transit rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="3.3333" displayUnit="1/min">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="34" />
+                  <Info min="0" flag="54" seq="1" ref="0" bb="32" group="46" />
                 </Parameter>
-                <Parameter id="RztvGmTxtUqOx1hoHtZdCQ" name="Thickness_p1" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0076" displayUnit="cm">
+                <Parameter id="E11Kl_rrAkGZ0Z4dc1N85g" name="L_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.6886041141" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="34" />
                 </Parameter>
-                <Parameter id="kHCjOpji0k-FllNDvNuGJQ" name="r2_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.008955843">
+                <Parameter id="wgZn0u01dkSAkgmQY5lAZA" name="L_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.144607745">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="34" />
                 </Parameter>
-                <Parameter id="RzjijraRDkKRow2iyUJhXg" name="r2_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0384322177" displayUnit="cm">
+                <Parameter id="AWJM2HSnNkGP_8_dhmnDUw" name="Microvilli factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                  <Info min="0" flag="38" seq="1" ref="0" bb="32" group="33" />
                 </Parameter>
-                <Parameter id="BU0V9yvEHk2PO9DcKOu9Lw" name="r1_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.015672726">
+                <Parameter id="nBx2oSLXvUCWHMqyVd5MDA" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="5.7">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                  <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
+                  <Info min="0" max="14" flag="122" seq="1" ref="0" bb="32" group="41" />
                 </Parameter>
-                <Parameter id="OvlvK4g5MUqAIY-aRlAqew" name="r1_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.067256381" displayUnit="cm">
+                <Parameter id="GFZpebERLk2ZII--wLmMYw" name="r1_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.067256381" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="mWCL5T1zlkCyxWl7h44hpw" name="Microvilli factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                <Parameter id="xDH5URwYKk2jTRmerwmigA" name="r1_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.015672726">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="38" seq="1" ref="0" bb="32" group="33" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="Mabenhy3C0eontq1XGgkTg" name="Thickness_p3" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.08637087" displayUnit="1/cm">
+                <Parameter id="WYDB4E2VpUezlNl1Ib96Fw" name="r2_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0384322177" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="3EhRwYdHS0qltw_NTSnWNA" name="L_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.6886041141" displayUnit="cm">
+                <Parameter id="y6qaw-ZNZk6fyPxAQ_0AfA" name="r2_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.008955843">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="34" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="bUbaCirkxkCdcEjtZb5t9g" name="Intestinal transit rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="3.3333" displayUnit="1/min">
+                <Parameter id="L7bgKi6lLEqkdrDz3rvSGQ" name="Thickness_p1" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0076" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="54" seq="1" ref="0" bb="32" group="46" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
                 </Parameter>
-                <Parameter id="XKi2G-NvfUW032pXMhxzpg" name="Fractional steady state fill level" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0060009">
+                <Parameter id="-Zfz_S1GMEC-x-qDV-rZuA" name="Thickness_p2" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0394956146" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="58" seq="1" ref="0" bb="32" group="43" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
                 </Parameter>
-                <Parameter id="Ryr0wjrMyEC0lFxBBFT7yQ" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="5.7">
+                <Parameter id="ybhS71caUUuAT-1lx2esnQ" name="Thickness_p3" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.08637087" displayUnit="1/cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
-                  <Info min="0" max="14" flag="122" seq="1" ref="0" bb="32" group="41" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
                 </Parameter>
-                <DistributedParameter id="aBFojYBfe0eAXEYhXwBUWA" name="Effective surface area enhancement factor" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="t6Pn0e7a4kePCxAc3A5t9Q" mode="Logical" isDefault="1">
+                <DistributedParameter id="qF2gBd-8uUuLhJD9jT7BbQ" name="Effective surface area enhancement factor" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="SB2_y_7EFUuralHkfU8gOQ" mode="Logical" isDefault="1">
                   <Children>
-                    <Parameter id="OkIXxHQhH0KXub0Ny41IYw" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                    <Parameter id="g5DzoxDz70eYONcbAdarYw" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
                       <Info min="0" flag="18" seq="1" ref="0" bb="32" group="32" />
                     </Parameter>
-                    <Parameter id="Vzht0hAizUG9uoLMKh-_6A" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.5">
+                    <Parameter id="u_Oy5cSEDU6izzm1ptROPQ" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.5">
                       <Info min="0" flag="50" seq="1" ref="0" bb="32" group="32" />
                     </Parameter>
                   </Children>
@@ -5407,247 +5448,250 @@
                   </Tags>
                   <Info min="0" flag="122" seq="1" ref="0" bb="32" group="32" />
                 </DistributedParameter>
-                <Container id="p6VUoFXYfEGz03mSYFznJw" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="upzDU-jdTkioYhguliH-IA" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                   <Children>
-                    <Parameter id="-V1SCRLvfkWzNb30gMnMKA" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" isDefault="1">
-                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                    <Parameter id="NxJfMgEdckSJvfb0tm1zCw" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal_GI" isDefault="1">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                     </Parameter>
-                    <Parameter id="GZpG0q7GekutQFJC_6juig" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" isDefault="1">
-                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                    <Parameter id="-hIXxNbdUEO6F6YbxGN9Eg" name="Oral mass absorbed segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" rHSFormula="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_coltrans" value="0" displayUnit="µmol">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                    </Parameter>
+                    <Parameter id="S6iQppghc06zynRRsfS4jg" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                     </Parameter>
-                    <Parameter id="AjRsuvOgl06kNKVFkvwgSQ" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" isDefault="1">
+                    <Parameter id="ufZTGfMBNkufm7L1au4MDQ" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="j9WKkABOy0ecQnXz9I80zw" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" isDefault="1">
+                    <Parameter id="9eSjldQlLEGT8vp5Y1Mmmw" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="jXu0AHBfFESqCbMUpbGkmA" name="Solubility" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_IntestinalSolubility" isDefault="1" displayUnit="mg/l">
-                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="42" />
+                    <Parameter id="xCAamQI4K0iSD5dGV5ygwQ" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="vDOHUi4fW0Kjq1pG-75nlQ" name="Solubility table" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.TableFormulaWithXArgument_SolubilityTable" isDefault="1" displayUnit="mg/l">
-                      <Info min="0" flag="50" seq="1" ref="0" bb="2" group="42" />
+                    <Parameter id="2EMgF5VpK0S84_Vf5diWEg" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="t0Dq18cprkuhV3vRPk_mQg" name="Solubility_pKa_pH_Factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" isDefault="1">
-                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="18" />
+                    <Parameter id="LILrseXmcEGFuDq2cdsohA" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="qvo3Mw_9C022sWUajYnGWg" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
-                      <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                    <Parameter id="auBGkW5sF0-hNQv8x7vuMA" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="7eug3Fw50UOervlEaNhTFA" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" isDefault="1">
+                    <Parameter id="lvfFgtjQEE6GMshkF5lAXw" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="xBvUjzVmbkekzf6hS1ynog" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" isDefault="1">
+                    <Parameter id="0z0-x2IPRECN3dipGvpTtA" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="Hfrv1YQXokW8uAW6pluIyA" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" isDefault="1">
+                    <Parameter id="RBZ3hF_EIEuVBZQk8I0w4g" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="ENOHK9mBQkW-3lxqpiseMg" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal_GI" isDefault="1">
-                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                    <Parameter id="wkV4zF-b0Eac-FryEBT-kA" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="ELp6gwOemkqZFNlVRVB_8A" name="Oral mass absorbed segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" rHSFormula="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_coltrans" value="0" displayUnit="µmol">
-                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                    <Parameter id="dSG5mXELYkuwcblYUzfigw" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="DmHmci7nvk6OzjhDL8hXzw" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
-                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                    <Parameter id="-ixY8ZdYjku3yY66o94g-w" name="Solubility" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_IntestinalSolubility" isDefault="1" displayUnit="mg/l">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="42" />
                     </Parameter>
-                    <Parameter id="VwxFt1iFSUONVHbApEXpBw" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" isDefault="1">
-                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                    <Parameter id="aKKo9GYOlUycwDCyUkEthw" name="Solubility table" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.TableFormulaWithXArgument_SolubilityTable" isDefault="1" displayUnit="mg/l">
+                      <Info min="0" flag="50" seq="1" ref="0" bb="2" group="42" />
                     </Parameter>
-                    <Parameter id="oNKONiuogUuVqSqvmXHmTg" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" isDefault="1">
-                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                    <Parameter id="5RWcUTI1nEmrwYgc4FX9Kg" name="Solubility_pKa_pH_Factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" isDefault="1">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="y1VAcIiB1keftDOhliH5sA" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" isDefault="1">
-                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                    <Parameter id="Fkw1lLb_z0qIIWqbXkq1lg" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                      <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                     </Parameter>
-                    <Parameter id="W4tTbYuDl0CEc2HVy4wu0g" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" isDefault="1">
-                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                    <Parameter id="wYKZ-Ot7OUCytbAGoqrdYQ" name="Effective concentration in lumen" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_EffectiveLumenConcentration" isDefault="1" displayUnit="µmol/l">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="42" />
                     </Parameter>
                   </Children>
                 </Container>
               </Children>
             </Container>
-            <Container id="JbHmfXgfJ0agDpPA7oV89g" name="ColonDescendens" mode="Physical" containerType="Compartment">
+            <Container id="PIYPudRTc0ObXI5ZSrWFNg" name="ColonDescendens" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="Lumen" />
                 <Tag value="LumenSegment" />
               </Tags>
               <Children>
-                <Parameter id="408i3adWlUC9OqUCG1rrPg" name="Effective surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_EffectiveSurfaceArea" isDefault="1" displayUnit="cm²">
+                <Parameter id="Jrofnq75BkaX_qx-lcM0YA" name="Absorption of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Outflow_ColonDescendens" isDefault="1" displayUnit="1/min">
+                  <Info flag="54" seq="1" ref="0" bb="2" group="63" />
+                </Parameter>
+                <Parameter id="kZl6SZA31E6r4Zo7sp-8Wg" name="Distal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R2" isDefault="1" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
-                  <Info min="0" flag="52" seq="1" ref="0" bb="32" group="33" />
-                </Parameter>
-                <Parameter id="G9StaHUkRECKWSrS0DVVOQ" name="Absorption of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Outflow_ColonDescendens" isDefault="1" displayUnit="1/min">
-                  <Info flag="54" seq="1" ref="0" bb="2" group="63" />
+                  <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="5WkXjqJb6Eys81fNdfJPFQ" name="Thickness of gut wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Thickness" isDefault="1" displayUnit="cm">
+                <Parameter id="c20craTn0Ui2zv7rE5GvJg" name="Effective surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_EffectiveSurfaceArea" isDefault="1" displayUnit="cm²">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="38" seq="1" ref="0" bb="32" group="45" />
+                  <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
+                  <Info min="0" flag="52" seq="1" ref="0" bb="32" group="33" />
                 </Parameter>
-                <Parameter id="-4lA1fcnx0G4A4SjmV0Tpg" name="FillLevelFlag" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevelFlagFlag" isDefault="1">
+                <Parameter id="4vp4rM7U7kmtsy9yrFGnaw" name="FillLevelFlag" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevelFlagFlag" isDefault="1">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="2xgX6oZxm0uo3j_jCEk8fQ" name="Fraction of geometric volume filled with liquid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevel" isDefault="1">
+                <Parameter id="WIlJaqqup0mHVz9W6rp_Cw" name="Fraction of geometric volume filled with liquid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevel" isDefault="1">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="7RM1L_HFkEOwJ2qspH3JBA" name="Geometric surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Area" isDefault="1" displayUnit="cm²">
+                <Parameter id="ZWDyHudIEkuhdQFpOJVG4g" name="Geometric surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Area" isDefault="1" displayUnit="cm²">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info min="0" flag="62" seq="1" ref="0" bb="32" group="33" />
                 </Parameter>
-                <Parameter id="kI8enN-zq0y75MoDTQCPsw" name="Intestinal transit rate (absolute)" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_InverseLITT_Factor_ColonDescendens" isDefault="1" displayUnit="1/min">
+                <Parameter id="zxqZxhdAf0ORS_JFTqY-Ug" name="Intestinal transit rate (absolute)" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_InverseLITT_Factor_ColonDescendens" isDefault="1" displayUnit="1/min">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="hiuikgID5UCgLnGap0wdDQ" name="Length" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Length" isDefault="1" displayUnit="cm">
+                <Parameter id="jdhxwFshzU27krJ_EXPyoA" name="Length" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Length" isDefault="1" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info min="0" flag="106" seq="1" ref="0" bb="32" group="34" />
                 </Parameter>
-                <Parameter id="hAhuWXwJ-0GITr84Dgi29Q" name="Liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Liquid_StartValue" isDefault="1" rHSFormula="Lumen_PKSim.LiquidRHS_coldesc" displayUnit="l">
+                <Parameter id="Rg0tiW4v70eW8By8rb5fwA" name="Liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Liquid_StartValue" isDefault="1" rHSFormula="Lumen_PKSim.LiquidRHS_coldesc" displayUnit="l">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="Osbi9kMXtU-GQBSnNh7ekg" name="Liquid transfer rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_LiquidTransferRate_coldesc" isDefault="1" displayUnit="l/min">
+                <Parameter id="uttoRDwxRE2lDNluZeaKug" name="Liquid transfer rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_LiquidTransferRate_coldesc" isDefault="1" displayUnit="l/min">
                   <Info flag="52" seq="1" ref="0" bb="2" group="39" />
                 </Parameter>
-                <Parameter id="7vMq1ZtZLUStQP84rDd2Ow" name="Secretion of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Inflow_ColonDescendens" isDefault="1" displayUnit="l/min">
-                  <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
-                </Parameter>
-                <Parameter id="lK_Y-Pf3sE-LCKoDJucHlg" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_LumenSegment" isDefault="1" displayUnit="l">
-                  <Info min="0" flag="62" seq="1" ref="0" bb="2" group="56" />
-                </Parameter>
-                <Parameter id="WPkCNj_RwUaRkfpm341b8Q" name="Volume (gut wall)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="MucosaVolume_Human.PARAM_VolumeGutWall_ColonDescendens" isDefault="1" displayUnit="l">
+                <Parameter id="4mmLz7co7ESjLOcP2L_EFQ" name="Proximal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R1" isDefault="1" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="62" seq="1" ref="0" bb="32" group="44" />
+                  <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="PZ_vVDShkkmgiAGpIq477g" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
-                  <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                <Parameter id="0AvUNhvGqUKpHgFF81RtUg" name="Secretion of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Inflow_ColonDescendens" isDefault="1" displayUnit="l/min">
+                  <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="qo7IZkswBkSO1zHdcwOwcg" name="Distal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R2" isDefault="1" displayUnit="cm">
+                <Parameter id="xp28LKS5AU2dvRxqhvlq9A" name="Thickness of gut wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Thickness" isDefault="1" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
+                  <Info min="0" flag="38" seq="1" ref="0" bb="32" group="45" />
+                </Parameter>
+                <Parameter id="KQ3nUYwopUS7cInaAiKpJQ" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_LumenSegment" isDefault="1" displayUnit="l">
+                  <Info min="0" flag="62" seq="1" ref="0" bb="2" group="56" />
                 </Parameter>
-                <Parameter id="1t0yaZ6nH0-t_6Y6aEP43g" name="Proximal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R1" isDefault="1" displayUnit="cm">
+                <Parameter id="A3yBL10rW0mFrMqq9U5l1w" name="Volume (gut wall)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="MucosaVolume_Human.PARAM_VolumeGutWall_ColonDescendens" isDefault="1" displayUnit="l">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
+                  <Info min="0" flag="62" seq="1" ref="0" bb="32" group="44" />
+                </Parameter>
+                <Parameter id="Is-JNU1q8kCPiCtSS6M2eg" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                  <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                 </Parameter>
-                <Parameter id="1O8x_BdnEE2y_upQ2ViuhA" name="r1_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0384322177" displayUnit="cm">
+                <Parameter id="kt3D-iZetEGl63fIzNFRLA" name="Fractional steady state fill level" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0060009">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                  <Info min="0" flag="58" seq="1" ref="0" bb="32" group="43" />
                 </Parameter>
-                <Parameter id="TRu--Pqm3UWIBIkbjj2x3A" name="Thickness_p3" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.08977747" displayUnit="1/cm">
+                <Parameter id="-HJQd80el0eaQlDoLisl_Q" name="Intestinal transit rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="5" displayUnit="1/min">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                  <Info min="0" flag="54" seq="1" ref="0" bb="32" group="46" />
                 </Parameter>
-                <Parameter id="XUUvmzUsekabGXl-HJHKcQ" name="Thickness_p2" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0601543776" displayUnit="cm">
+                <Parameter id="WkwCRkIvdUmp3TJAsTynkA" name="L_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.4227543951" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="34" />
                 </Parameter>
-                <Parameter id="GO15q9CqgkWUTW_aXZflOQ" name="Thickness_p1" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0118" displayUnit="cm">
+                <Parameter id="MM6i8nQTXk-L22vzALJQNQ" name="L_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.098514277">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="34" />
                 </Parameter>
-                <Parameter id="3PUAkvcbc0OCcj-7iiaq8w" name="r2_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.008955843">
+                <Parameter id="W0MnjphDwU2fK_ff7nqd3A" name="Microvilli factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                  <Info min="0" flag="38" seq="1" ref="0" bb="32" group="33" />
                 </Parameter>
-                <Parameter id="1ATD3hJVOU6bfdXubNsOsA" name="r1_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.008955843">
+                <Parameter id="wOtiFW3OiEqvS4gqmi2r5Q" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="6.6">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                  <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
+                  <Info min="0" max="14" flag="122" seq="1" ref="0" bb="32" group="41" />
                 </Parameter>
-                <Parameter id="MgEETrJd-0OoLyFkKyWx8Q" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="6.6">
+                <Parameter id="wiwTbNTRB0iXjoIxGnvipQ" name="r1_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0384322177" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
-                  <Info min="0" max="14" flag="122" seq="1" ref="0" bb="32" group="41" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="eY8yZC9iw06ZWjZxikQ5Nw" name="Microvilli factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                <Parameter id="rnSdFURZikWArmCJHV3TFg" name="r1_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.008955843">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="38" seq="1" ref="0" bb="32" group="33" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="ummC5DnzdEOYVPAdbewjxA" name="L_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.098514277">
+                <Parameter id="3dbDBgCl00yuQzxTlovkPQ" name="r2_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0384322177" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="34" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="eaLv2ZfySEqZgwPAZwrYnQ" name="L_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.4227543951" displayUnit="cm">
+                <Parameter id="a01H0QMJj0q2QeEg62QaUg" name="r2_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.008955843">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="34" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="fxC93NyfikeaYjIgePlJ7g" name="Intestinal transit rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="5" displayUnit="1/min">
+                <Parameter id="FQ_yKotty0GcGpvvSQDuLg" name="Thickness_p1" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0118" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="54" seq="1" ref="0" bb="32" group="46" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
                 </Parameter>
-                <Parameter id="U2asTOsKzEyvEoUg-hCwgA" name="Fractional steady state fill level" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0060009">
+                <Parameter id="_d6TQiyK80WvRaigEeJ2RA" name="Thickness_p2" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0601543776" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="58" seq="1" ref="0" bb="32" group="43" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
                 </Parameter>
-                <Parameter id="0_rv8y6_w0a9ihu9JZ8txg" name="r2_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0384322177" displayUnit="cm">
+                <Parameter id="_kaRRjMm602ilyBIN_aaOw" name="Thickness_p3" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.08977747" displayUnit="1/cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
                 </Parameter>
-                <DistributedParameter id="i3e1xPwum0S2inm4_5o6QA" name="Effective surface area enhancement factor" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="xhRkjLvmw0m6zwRmBMpkYg" mode="Logical" isDefault="1">
+                <DistributedParameter id="33k4UJpzfUS_aWkrOUuxwg" name="Effective surface area enhancement factor" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="wvPILkXjaka3EybjM1RzKA" mode="Logical" isDefault="1">
                   <Children>
-                    <Parameter id="LypdjxdFmkKZ9j_0a9-rAQ" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                    <Parameter id="1XOqC43SqUq-CsQWLH9jvg" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
                       <Info min="0" flag="18" seq="1" ref="0" bb="32" group="32" />
                     </Parameter>
-                    <Parameter id="gva1mez92063DBVx_evK9Q" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.5">
+                    <Parameter id="usZCOd0RpE-JltsEAPpwoA" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.5">
                       <Info min="0" flag="50" seq="1" ref="0" bb="32" group="32" />
                     </Parameter>
                   </Children>
@@ -5657,247 +5701,250 @@
                   </Tags>
                   <Info min="0" flag="122" seq="1" ref="0" bb="32" group="32" />
                 </DistributedParameter>
-                <Container id="M2Uihuy-DE2FrVv7ABJGpQ" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="V3VocWhnC0WW1uCXnPYzLg" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                   <Children>
-                    <Parameter id="kzxrH73xHkOtbuiak0J8ug" name="Solubility_pKa_pH_Factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" isDefault="1">
-                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="18" />
-                    </Parameter>
-                    <Parameter id="2pjzpzlNBkClM_WSuOJS5Q" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" isDefault="1">
-                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
-                    </Parameter>
-                    <Parameter id="R6lM_9hbwEaA1L6WYKZpzw" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal_GI" isDefault="1">
+                    <Parameter id="90b7ckvZb06jfMP-XbA9IQ" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal_GI" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                     </Parameter>
-                    <Parameter id="qt4-K-iXtEuIMPu7evvwIg" name="Oral mass absorbed segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" rHSFormula="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_coldesc" value="0" displayUnit="µmol">
+                    <Parameter id="jg-dt27INEqUWKFrlBKlQQ" name="Oral mass absorbed segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" rHSFormula="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_coldesc" value="0" displayUnit="µmol">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                     </Parameter>
-                    <Parameter id="s3E7H_BN7Ua1-DXUmJIGnQ" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                    <Parameter id="P2nmvdzXMEWNeoGNqb1d5w" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                     </Parameter>
-                    <Parameter id="NTzRehR9r0iqHnqqa13mww" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" isDefault="1">
+                    <Parameter id="u2eiSwnSeU2WWLwRqo01Tw" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                    </Parameter>
+                    <Parameter id="Y3r5szKGb0Wya6BSuCEVKQ" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                    </Parameter>
+                    <Parameter id="7aZ18byNWkuI8mi8E0EwGg" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="7KJ-tUGZfECvVDORi9j3Cw" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" isDefault="1">
+                    <Parameter id="C8Jk87XC106XnklVGA0N3g" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="1Y1TGr___EyM6Jrfm5HseA" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" isDefault="1">
+                    <Parameter id="1URWOUAAt02XGxcE5QoFew" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="GOkgzGFeM02d8NhvVIxBxQ" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" isDefault="1">
+                    <Parameter id="fnrqzwo440K_ooCu0hKs1Q" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="E0qOP1ZUoUyAtIQG6BfsmQ" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" isDefault="1">
+                    <Parameter id="3NjDG7Bsx026kgT1ftHo9A" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="ILxe7x3AdkqkU7N7t1TTTQ" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" isDefault="1">
+                    <Parameter id="hFyEXY2NKE6cgQMZkYy84Q" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="9TUuumrcqkulY02rlH8hGA" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" isDefault="1">
+                    <Parameter id="eHxDCC1GuUCV7fLMnrZTHA" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="ZPpP2bGHn0a-ep9fXER7tQ" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" isDefault="1">
+                    <Parameter id="nW7mTYvhXky99yvu-mGFVQ" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="BAMVtKyJBEWlhUG_-Mpu0g" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" isDefault="1">
+                    <Parameter id="KMcivIP_P0Ok5me1PhHSvw" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="pq5SnH8c8UGQfD8Rvj1LWQ" name="Solubility" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_IntestinalSolubility" isDefault="1" displayUnit="mg/l">
+                    <Parameter id="HtMrtV3cW0q2TJEZJ_oW5w" name="Solubility" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_IntestinalSolubility" isDefault="1" displayUnit="mg/l">
                       <Info min="0" flag="122" seq="1" ref="0" bb="2" group="42" />
                     </Parameter>
-                    <Parameter id="cHb-dZt8oECYSKA9DF_EMQ" name="Solubility table" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.TableFormulaWithXArgument_SolubilityTable" isDefault="1" displayUnit="mg/l">
+                    <Parameter id="LJzuX3HiyUyy5y-NW12nmQ" name="Solubility table" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.TableFormulaWithXArgument_SolubilityTable" isDefault="1" displayUnit="mg/l">
                       <Info min="0" flag="50" seq="1" ref="0" bb="2" group="42" />
                     </Parameter>
-                    <Parameter id="_U7lT3moWkKjxuYIxLQOzw" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" isDefault="1">
-                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                    <Parameter id="ObLXWBm-nU2Q2brRjcoQjw" name="Solubility_pKa_pH_Factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" isDefault="1">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="DuXXmnbOgEygmJwrgHwf5Q" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                    <Parameter id="wJYpFTLn8UyAbLmu0uxAvQ" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
                       <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                     </Parameter>
+                    <Parameter id="ZTJKWu1RLkWc8bo43RjtcA" name="Effective concentration in lumen" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_EffectiveLumenConcentration" isDefault="1" displayUnit="µmol/l">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="42" />
+                    </Parameter>
                   </Children>
                 </Container>
               </Children>
             </Container>
-            <Container id="IUIlF5c6mEeLyH0-jGRL5g" name="ColonSigmoid" mode="Physical" containerType="Compartment">
+            <Container id="WT1bl4RAt0mxWQ1qvDeWTQ" name="ColonSigmoid" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="Lumen" />
                 <Tag value="LumenSegment" />
               </Tags>
               <Children>
-                <Parameter id="wEAN0F2mp0izXlU5fcfaSg" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_LumenSegment" isDefault="1" displayUnit="l">
-                  <Info min="0" flag="62" seq="1" ref="0" bb="2" group="56" />
+                <Parameter id="OTZ6BTBDgU-diq9HJsxiQw" name="Absorption of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Outflow_ColonSigmoid" isDefault="1" displayUnit="1/min">
+                  <Info flag="54" seq="1" ref="0" bb="2" group="63" />
+                </Parameter>
+                <Parameter id="eOzCH5MET0yZUBE8RD306w" name="Distal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R2" isDefault="1" displayUnit="cm">
+                  <Tags>
+                    <Tag value="Lumen" />
+                    <Tag value="LumenSegment" />
+                  </Tags>
+                  <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
+                </Parameter>
+                <Parameter id="A6dqFtK1YE61zX7OsKY0TA" name="Effective surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_EffectiveSurfaceArea" isDefault="1" displayUnit="cm²">
+                  <Tags>
+                    <Tag value="Lumen" />
+                    <Tag value="LumenSegment" />
+                  </Tags>
+                  <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
+                  <Info min="0" flag="52" seq="1" ref="0" bb="32" group="33" />
+                </Parameter>
+                <Parameter id="e-nB__uqgEe_gM4A6iXKqg" name="FillLevelFlag" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevelFlagFlag" isDefault="1">
+                  <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="14-txyCD9U2D-xqnitMf5g" name="Geometric surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Area" isDefault="1" displayUnit="cm²">
+                <Parameter id="17YAbyVERUuSC9-ud5wvMg" name="Fraction of geometric volume filled with liquid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevel" isDefault="1">
+                  <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                </Parameter>
+                <Parameter id="L1iYUEa7Tk6iqxZAfikYeA" name="Geometric surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Area" isDefault="1" displayUnit="cm²">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info min="0" flag="62" seq="1" ref="0" bb="32" group="33" />
                 </Parameter>
-                <Parameter id="TUo6m90jtEWeFSF72ZLB7Q" name="Intestinal transit rate (absolute)" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_InverseLITT_Factor_ColonSigmoid" isDefault="1" displayUnit="1/min">
+                <Parameter id="zpUx0L3y_Eq4aZjl_LLvGQ" name="Intestinal transit rate (absolute)" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_InverseLITT_Factor_ColonSigmoid" isDefault="1" displayUnit="1/min">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="xveF_sDnkk2IQgoRh_Eklg" name="Length" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Length" isDefault="1" displayUnit="cm">
+                <Parameter id="8_K7paY8XkqhtvjSG1QAvg" name="Length" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Length" isDefault="1" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info min="0" flag="106" seq="1" ref="0" bb="32" group="34" />
                 </Parameter>
-                <Parameter id="WSDMqflAjEaTYQskb2uvwA" name="Liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Liquid_StartValue" isDefault="1" rHSFormula="Lumen_PKSim.LiquidRHS_colsigm" displayUnit="l">
+                <Parameter id="Jm6ISXRnR0ykzcz6JUkOxg" name="Liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Liquid_StartValue" isDefault="1" rHSFormula="Lumen_PKSim.LiquidRHS_colsigm" displayUnit="l">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="ERK3d6hN3kOX9TvkrfsR6Q" name="Liquid transfer rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_LiquidTransferRate_colsigm" isDefault="1" displayUnit="l/min">
+                <Parameter id="spCkf-qEUkumeP4OdcaXpw" name="Liquid transfer rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_LiquidTransferRate_colsigm" isDefault="1" displayUnit="l/min">
                   <Info flag="52" seq="1" ref="0" bb="2" group="39" />
                 </Parameter>
-                <Parameter id="ZHwIEshq5k6PMtX-g9twGg" name="Proximal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R1" isDefault="1" displayUnit="cm">
+                <Parameter id="Afre6rNi8U6zRe3HvcKiuQ" name="Proximal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R1" isDefault="1" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="pUu1cC4bEUiYjGKmHwHlOQ" name="Secretion of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Inflow_ColonSigmoid" isDefault="1" displayUnit="l/min">
+                <Parameter id="cfZ6e3D40kG444x0Lrsn5Q" name="Secretion of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Inflow_ColonSigmoid" isDefault="1" displayUnit="l/min">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="qakeGk16pEWAkkBxy7AANg" name="Thickness of gut wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Thickness" isDefault="1" displayUnit="cm">
+                <Parameter id="-g8aHNrCgEW2B03-MoIUsg" name="Thickness of gut wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Thickness" isDefault="1" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info min="0" flag="38" seq="1" ref="0" bb="32" group="45" />
                 </Parameter>
-                <Parameter id="DRmsAwS4okCM0CW9KOzcfg" name="Effective surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_EffectiveSurfaceArea" isDefault="1" displayUnit="cm²">
-                  <Tags>
-                    <Tag value="Lumen" />
-                    <Tag value="LumenSegment" />
-                  </Tags>
-                  <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
-                  <Info min="0" flag="52" seq="1" ref="0" bb="32" group="33" />
+                <Parameter id="NEwHn2fWFESuaRWhlCg_KQ" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_LumenSegment" isDefault="1" displayUnit="l">
+                  <Info min="0" flag="62" seq="1" ref="0" bb="2" group="56" />
                 </Parameter>
-                <Parameter id="e_CNGg_dOEGBrvh1J5rKfA" name="Volume (gut wall)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="MucosaVolume_Human.PARAM_VolumeGutWall_ColonSigmoid" isDefault="1" displayUnit="l">
+                <Parameter id="IIKwY-bZi0-QLLpOHGSkUQ" name="Volume (gut wall)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="MucosaVolume_Human.PARAM_VolumeGutWall_ColonSigmoid" isDefault="1" displayUnit="l">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info min="0" flag="62" seq="1" ref="0" bb="32" group="44" />
                 </Parameter>
-                <Parameter id="86-kT9HN9kelzhTN5gEUGQ" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                <Parameter id="dSBOWuQjGUaPxdeXtzCusw" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
                   <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                 </Parameter>
-                <Parameter id="N3GWcZJt-EKaH3-TyGmkQQ" name="Fraction of geometric volume filled with liquid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevel" isDefault="1">
-                  <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
-                </Parameter>
-                <Parameter id="6pPn_UrX60C2OMv3Ds5TmA" name="FillLevelFlag" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevelFlagFlag" isDefault="1">
-                  <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
-                </Parameter>
-                <Parameter id="YBBRnRvAfEG8CvClfS-Sxg" name="Absorption of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Outflow_ColonSigmoid" isDefault="1" displayUnit="1/min">
-                  <Info flag="54" seq="1" ref="0" bb="2" group="63" />
-                </Parameter>
-                <Parameter id="FmQU5Ix1gUuJBs5VTn77qA" name="Distal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R2" isDefault="1" displayUnit="cm">
+                <Parameter id="MOOY1B835U--ekFcF1bJog" name="Fractional steady state fill level" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0060009">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
+                  <Info min="0" flag="58" seq="1" ref="0" bb="32" group="43" />
                 </Parameter>
-                <Parameter id="jfZevH_QMk6dMP_45yRGLw" name="L_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5337898629" displayUnit="cm">
+                <Parameter id="aWgTxoLuo02_Vc6JqQwZEg" name="Intestinal transit rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="4.0741" displayUnit="1/min">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="34" />
+                  <Info min="0" flag="54" seq="1" ref="0" bb="32" group="46" />
                 </Parameter>
-                <Parameter id="FLm9ZVpa0ka3sE78FTF9Ng" name="r2_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0384322177" displayUnit="cm">
+                <Parameter id="1lGGry8JmUevV2doD6xKaA" name="L_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5337898629" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="34" />
                 </Parameter>
-                <Parameter id="RuQagmwh0US6M0PcyR_Dyw" name="Thickness_p3" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0889014" displayUnit="1/cm">
+                <Parameter id="snbmUjcNPUGk13HMmJQXJA" name="L_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.121300709">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="34" />
                 </Parameter>
-                <Parameter id="M2t_R79J0kCn0AROdN57yQ" name="Thickness_p2" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0274432593" displayUnit="cm">
+                <Parameter id="IVz1MVOW8E-8ua_NTe9ZtA" name="Microvilli factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                  <Info min="0" flag="38" seq="1" ref="0" bb="32" group="33" />
                 </Parameter>
-                <Parameter id="r8hoez7ct0uikahy2Y1oxA" name="Fractional steady state fill level" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0060009">
+                <Parameter id="YcUkdJRUj0ST4IBGIzqTYQ" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="6.6">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="58" seq="1" ref="0" bb="32" group="43" />
+                  <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
+                  <Info min="0" max="14" flag="122" seq="1" ref="0" bb="32" group="41" />
                 </Parameter>
-                <Parameter id="mDf7-pRFl0qJ1H78Qpqz6w" name="r2_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.008955843">
+                <Parameter id="a_CkJvNoc0iUJpUPtlcNIA" name="r1_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0384322177" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="GJ8VjFv57kyEPIk7ms4m3Q" name="Intestinal transit rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="4.0741" displayUnit="1/min">
-                  <Tags>
-                    <Tag value="Lumen" />
-                    <Tag value="LumenSegment" />
-                  </Tags>
-                  <Info min="0" flag="54" seq="1" ref="0" bb="32" group="46" />
-                </Parameter>
-                <Parameter id="LOee3iLTCEaBtShkHozaKQ" name="r1_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.008955843">
+                <Parameter id="822T5SCPqUyO7dISwpGdTw" name="r1_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.008955843">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="MEEew-ZQ1k-rbNJSkbJrog" name="r1_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0384322177" displayUnit="cm">
+                <Parameter id="w3MZlFQgKU66GZ2EOey6Ug" name="r2_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0384322177" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="oKFLUq-ZWU2nmliXCOk_6A" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="6.6">
+                <Parameter id="dI7JruSvL0CHQesESzpPyQ" name="r2_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.008955843">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
-                  <Info min="0" max="14" flag="122" seq="1" ref="0" bb="32" group="41" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="4WZnkJBEcU-F1-F6-6a1Yg" name="Microvilli factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                <Parameter id="q88koRxFCUObBWy3DKVlOw" name="Thickness_p1" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.00536" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="38" seq="1" ref="0" bb="32" group="33" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
                 </Parameter>
-                <Parameter id="ADTp-c10r0i9BQopzxsq1w" name="L_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.121300709">
+                <Parameter id="F7VnNSPCgUeElIgnRpO9Ug" name="Thickness_p2" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0274432593" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="34" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
                 </Parameter>
-                <Parameter id="nKABCGvCFEayGHFBSg9Xxw" name="Thickness_p1" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.00536" displayUnit="cm">
+                <Parameter id="G9LN4bhorEiYmrr__aak3g" name="Thickness_p3" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0889014" displayUnit="1/cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info flag="54" seq="1" ref="0" bb="32" group="45" />
                 </Parameter>
-                <DistributedParameter id="bv6W116tIk-VMLhiLejlOg" name="Effective surface area enhancement factor" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="FUq2AWm1c0ylYEw80c2Auw" mode="Logical" isDefault="1">
+                <DistributedParameter id="kXba_logjUuej5eqIfafPA" name="Effective surface area enhancement factor" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="H2v0tRqvr0OGHfVzXb-Kwg" mode="Logical" isDefault="1">
                   <Children>
-                    <Parameter id="DLhujBSV_UKI6VMwTK4N_g" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                    <Parameter id="laFFm2EVGE-lK5OVOggMPA" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
                       <Info min="0" flag="18" seq="1" ref="0" bb="32" group="32" />
                     </Parameter>
-                    <Parameter id="9idZXSwISUGgqU2X7irc3A" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.5">
+                    <Parameter id="dZZfefRSVU2HTozVNaBO_w" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.5">
                       <Info min="0" flag="50" seq="1" ref="0" bb="32" group="32" />
                     </Parameter>
                   </Children>
@@ -5907,83 +5954,86 @@
                   </Tags>
                   <Info min="0" flag="122" seq="1" ref="0" bb="32" group="32" />
                 </DistributedParameter>
-                <Container id="fn5A_Gfh8k2heIOF27kWfQ" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="SKL3gkqtg0KW1LB1Urhxfw" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                   <Children>
-                    <Parameter id="lo7UseNN9k6YGStpf7-OOQ" name="Solubility" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_IntestinalSolubility" isDefault="1" displayUnit="mg/l">
-                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="42" />
+                    <Parameter id="MiQwhGeFOk2iUWDRNhcn1g" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal_GI" isDefault="1">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                     </Parameter>
-                    <Parameter id="k6Seze-Sl0O1ukOeJMoRtA" name="Oral mass absorbed segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" rHSFormula="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_colsigm" value="0" displayUnit="µmol">
+                    <Parameter id="J_PP1NYzj0eUKXSW8guZ1w" name="Oral mass absorbed segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" rHSFormula="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_colsigm" value="0" displayUnit="µmol">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                     </Parameter>
-                    <Parameter id="QSYNC-DTLk-ZYRIs-sySPw" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                    <Parameter id="CzkrsiHrxEWW4Mwm3EMKyg" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                     </Parameter>
-                    <Parameter id="jYggbqmwsEqDGXQJmp6R7g" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" isDefault="1">
+                    <Parameter id="Rp9pNME5gkenVBg_g57anA" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                    </Parameter>
+                    <Parameter id="E0X4pPoiy0Wu1LbPoHBXZw" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="et2gCd7OWUi5RL25cj6wVA" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" isDefault="1">
+                    <Parameter id="Me0lcs7bFE-PxV9bu4UOCQ" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="0XCX6N-hNEWI8ZDhaajlJA" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" isDefault="1">
+                    <Parameter id="rPCq3JCGfU6t5LB60qF0bg" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="EEozHktGp0SN-LXV5cuIUA" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" isDefault="1">
+                    <Parameter id="49glN-t9F0SV83CzjR1Fxw" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="1yUaJybZh0mR-W4jwIFy6Q" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" isDefault="1">
+                    <Parameter id="uzjkvYdQi0KsxiobB3gFBg" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="YMCmrWKMoUmdkqoFhtKV-A" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" isDefault="1">
+                    <Parameter id="b8t0Ddh6Ik-p4OemkIpKkw" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="oNlpQWTWMUufQsBzzAQNkw" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" isDefault="1">
+                    <Parameter id="fNaqlyk2102su5zWzHYizw" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="R2_atwkj3k2-TFr2l4kFjA" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" isDefault="1">
+                    <Parameter id="5jPO8IRPpUqoQqrK6ukdCA" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="ZT5B2h7tNEWO_NMomldr6A" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" isDefault="1">
+                    <Parameter id="9Pogft1CIUqWVbEYFCPhBA" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="C1MNzNqKZkyQ8imQTeh6dA" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" isDefault="1">
+                    <Parameter id="HHNXv0WGzUGY3jOAJO59ow" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="_jjeJMLJNkSUJUUmb5mejg" name="Solubility table" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.TableFormulaWithXArgument_SolubilityTable" isDefault="1" displayUnit="mg/l">
+                    <Parameter id="AueofGHdzkyh7iGrnQA3Mw" name="Solubility" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_IntestinalSolubility" isDefault="1" displayUnit="mg/l">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="42" />
+                    </Parameter>
+                    <Parameter id="fFEl3xTU20SrkK4rxmSEAg" name="Solubility table" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.TableFormulaWithXArgument_SolubilityTable" isDefault="1" displayUnit="mg/l">
                       <Info min="0" flag="50" seq="1" ref="0" bb="2" group="42" />
                     </Parameter>
-                    <Parameter id="gV5ZZCrnB0eYrv7q-pg94A" name="Solubility_pKa_pH_Factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" isDefault="1">
+                    <Parameter id="WdiL4goB1Ey-P-lZZcRnQg" name="Solubility_pKa_pH_Factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="cgSvde7P80GPSbPoeEu6Fg" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                    <Parameter id="uvcXyMg0e0-1YZlTljmfBQ" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
                       <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                     </Parameter>
-                    <Parameter id="2Vi1zGXU_EiPfU-QqR2Kfw" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" isDefault="1">
-                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
-                    </Parameter>
-                    <Parameter id="0Xzg7UR5uEOx9Q_rO_JZAA" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal_GI" isDefault="1">
-                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                    <Parameter id="ISQkHz4Sn0GNcGmCHRboww" name="Effective concentration in lumen" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_EffectiveLumenConcentration" isDefault="1" displayUnit="µmol/l">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="42" />
                     </Parameter>
                   </Children>
                 </Container>
               </Children>
             </Container>
-            <Container id="6fn_3RiggkS4UkuFhro8Dw" name="Rectum" mode="Physical" containerType="Compartment">
+            <Container id="UpSKgnWYPEiXklQNAqrFdg" name="Rectum" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="Lumen" />
                 <Tag value="LumenSegment" />
               </Tags>
               <Children>
-                <Parameter id="1Or6MVymikCm8r8UGU2sTw" name="Absorption of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Outflow_Rectum" isDefault="1" displayUnit="1/min">
+                <Parameter id="6rdVsDEIsEWlnA6ykzVTQw" name="Absorption of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Outflow_Rectum" isDefault="1" displayUnit="1/min">
                   <Info flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="KI1hi9dpPUmGi5F3nDZaDg" name="Distal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R2" isDefault="1" displayUnit="cm">
+                <Parameter id="PtR1C3WNGEWROxsF2LquDQ" name="Distal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R2" isDefault="1" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="oTrLouJLs06cliNYednu6w" name="Effective surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_EffectiveSurfaceArea" isDefault="1" displayUnit="cm²">
+                <Parameter id="dpv35RkqEEmIWtSslFYaTA" name="Effective surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_EffectiveSurfaceArea" isDefault="1" displayUnit="cm²">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
@@ -5991,163 +6041,163 @@
                   <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
                   <Info min="0" flag="52" seq="1" ref="0" bb="32" group="33" />
                 </Parameter>
-                <Parameter id="EhTYQp3cZUa7qFIcgqI6qA" name="FillLevelFlag" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevelFlagFlag" isDefault="1">
+                <Parameter id="nIrq7wCid0uP1dKx41zulA" name="FillLevelFlag" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevelFlagFlag" isDefault="1">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="jKYl6xjPU02RZCq9lEdZVg" name="Fraction of geometric volume filled with liquid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevel" isDefault="1">
+                <Parameter id="xPqWdK-27Eu5V4NC3Xd0_g" name="Fraction of geometric volume filled with liquid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_FillLevel" isDefault="1">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="zcecVMDnEU2I9-f2E8OB7Q" name="Length" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Length" isDefault="1" displayUnit="cm">
-                  <Tags>
-                    <Tag value="Lumen" />
-                    <Tag value="LumenSegment" />
-                  </Tags>
-                  <Info min="0" flag="106" seq="1" ref="0" bb="32" group="34" />
-                </Parameter>
-                <Parameter id="KZK2pe0sb0qpbbFz9fTSRw" name="Geometric surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Area" isDefault="1" displayUnit="cm²">
+                <Parameter id="tKBx7FhwkEGae0fq9YuD-g" name="Geometric surface area" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Area" isDefault="1" displayUnit="cm²">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info min="0" flag="62" seq="1" ref="0" bb="32" group="33" />
                 </Parameter>
-                <Parameter id="PgimrS1_LUGUPcNop0K7wQ" name="Volume (gut wall)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="MucosaVolume_Human.PARAM_VolumeGutWall_Rectum" isDefault="1" displayUnit="l">
+                <Parameter id="ZC9oC_pmTkS_cW8EGa1p-g" name="Intestinal transit rate (absolute)" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_InverseLITT_Factor_Rectum" isDefault="1" displayUnit="1/min">
+                  <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                </Parameter>
+                <Parameter id="HbPyVmXDbkOknOV6wUrH0A" name="Length" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Length" isDefault="1" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="62" seq="1" ref="0" bb="32" group="44" />
+                  <Info min="0" flag="106" seq="1" ref="0" bb="32" group="34" />
                 </Parameter>
-                <Parameter id="ZX0hv0diAkSR_rUYLy3TdQ" name="Liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Liquid_StartValue" isDefault="1" rHSFormula="Lumen_PKSim.LiquidRHS_rect" displayUnit="l">
+                <Parameter id="jJPSxEU9Vkedyq_NmarluQ" name="Liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Liquid_StartValue" isDefault="1" rHSFormula="Lumen_PKSim.LiquidRHS_rect" displayUnit="l">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="3bpJ4SeYjkG2pkziVDnrJA" name="Liquid transfer rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_LiquidTransferRate_rect" isDefault="1" displayUnit="l/min">
+                <Parameter id="OqGy02I070KtVU_4evJvFA" name="Liquid transfer rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_LiquidTransferRate_rect" isDefault="1" displayUnit="l/min">
                   <Info flag="52" seq="1" ref="0" bb="2" group="39" />
                 </Parameter>
-                <Parameter id="C7-FjtycgEmFbjZedub6Mw" name="Proximal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R1" isDefault="1" displayUnit="cm">
+                <Parameter id="SZ9fD2fb9EeSa-I2FPpWjw" name="Proximal radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R1" isDefault="1" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="Su4TeZOYnUSA9ikcxBSzbw" name="Secretion of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Inflow_Rectum" isDefault="1" displayUnit="l/min">
+                <Parameter id="edMi_0kKs0C6G2RGr0U1sA" name="Secretion of liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_Inflow_Rectum" isDefault="1" displayUnit="l/min">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="K0MMaIdq8kmTFZQxtkCypA" name="Thickness of gut wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Thickness" isDefault="1" displayUnit="cm">
+                <Parameter id="BpSmNiszxEW01KFwNSAPLA" name="Thickness of gut wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Thickness" isDefault="1" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info min="0" flag="38" seq="1" ref="0" bb="32" group="45" />
                 </Parameter>
-                <Parameter id="nIP3wcrgSkmNRjoPjqZRcw" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_LumenSegment" isDefault="1" displayUnit="l">
+                <Parameter id="lUwsfjnrckS_GGTHbrR19A" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_LumenSegment" isDefault="1" displayUnit="l">
                   <Info min="0" flag="62" seq="1" ref="0" bb="2" group="56" />
                 </Parameter>
-                <Parameter id="it5lDFQF7E-t3TSYvsLj_A" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
-                  <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
-                </Parameter>
-                <Parameter id="AMh8qhDb70KCAn9t-WwCkg" name="Intestinal transit rate (absolute)" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_InverseLITT_Factor_Rectum" isDefault="1" displayUnit="1/min">
-                  <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
-                </Parameter>
-                <Parameter id="IqZatP9_uUGmZLxbD0mbKQ" name="L_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.052420808">
+                <Parameter id="OhkjCSHhbUWVlOvHh-7tyw" name="Volume (gut wall)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="MucosaVolume_Human.PARAM_VolumeGutWall_Rectum" isDefault="1" displayUnit="l">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="34" />
+                  <Info min="0" flag="62" seq="1" ref="0" bb="32" group="44" />
+                </Parameter>
+                <Parameter id="QAwOd8tmOkusYRdTUnr8Xg" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                  <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                 </Parameter>
-                <Parameter id="rldYToyq_0mKEn-LC3fjGA" name="Intestinal transit rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="315.618" displayUnit="1/min">
+                <Parameter id="9jK8HZRJwkagMwTW6H1XSg" name="Fractional steady state fill level" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0060009">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="54" seq="1" ref="0" bb="32" group="46" />
+                  <Info min="0" flag="58" seq="1" ref="0" bb="32" group="43" />
                 </Parameter>
-                <Parameter id="OGO0oCs85Ui-6YYWJMrXyg" name="Fractional steady state fill level" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0060009">
+                <Parameter id="3pN_KKiNTk-So20DVEKUng" name="Intestinal transit rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="315.618" displayUnit="1/min">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="58" seq="1" ref="0" bb="32" group="43" />
+                  <Info min="0" flag="54" seq="1" ref="0" bb="32" group="46" />
                 </Parameter>
-                <Parameter id="9k3aUU1A-kOyXCZk3kTS6A" name="Microvilli factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                <Parameter id="bd2ztOKBJE6y8H7ghgfSTQ" name="L_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.1569046761" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info min="0" flag="38" seq="1" ref="0" bb="32" group="33" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="34" />
                 </Parameter>
-                <Parameter id="5qQARR3WsEiVOkqYmgFDoA" name="L_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.1569046761" displayUnit="cm">
+                <Parameter id="uVagcnTyqkm6q7-j2i4pIg" name="L_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.052420808">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info flag="54" seq="1" ref="0" bb="32" group="34" />
                 </Parameter>
-                <Parameter id="Je2gEuLMREelScstarKBmw" name="Thickness_p2" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0324721331" displayUnit="cm">
+                <Parameter id="JTWuj1lY50Gf1jiUGdsynw" name="Microvilli factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                  <Info min="0" flag="38" seq="1" ref="0" bb="32" group="33" />
                 </Parameter>
-                <Parameter id="VP4FBnxsukKWvFUpazcptA" name="Thickness_p3" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.10014267" displayUnit="1/cm">
+                <Parameter id="c7NRGjIeyEK4IVz_4qUMZA" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="6.6">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                  <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
+                  <Info min="0" max="14" flag="122" seq="1" ref="0" bb="32" group="41" />
                 </Parameter>
-                <Parameter id="xK4XQpaBdU6msRHQT0nA6g" name="Thickness_p1" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.00665" displayUnit="cm">
+                <Parameter id="3tpjaoyRAEyhKRL7wM6tVA" name="r1_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0384322177" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="-x0vKVV1L0uZ_bVohiwpGw" name="r2_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.005597402">
+                <Parameter id="zezCckK7CUaGkMml7JuVBA" name="r1_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.008955843">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="e4MzjrnubE2vh8b3kBbkeQ" name="r2_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0240201361" displayUnit="cm">
+                <Parameter id="lSIZcDDYWUKXOhbbGmra0w" name="r2_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0240201361" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="9CxBV0B-nUunta9gV_foSw" name="r1_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.008955843">
+                <Parameter id="PBWBiOdRakyjK4wS5QrRsw" name="r2_p1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.005597402">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
                   <Info flag="54" seq="1" ref="0" bb="32" group="35" />
                 </Parameter>
-                <Parameter id="B3qgN-lVSE612qoYxnseLw" name="r1_p0" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0384322177" displayUnit="cm">
+                <Parameter id="kaJAfAnFZky3kytdT0jKDg" name="Thickness_p1" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.00665" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
                 </Parameter>
-                <Parameter id="iuRMic_3M0OMAkKE1CgqRQ" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="6.6">
+                <Parameter id="abU4ZOsUn0O-p2WKGq2pyA" name="Thickness_p2" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0324721331" displayUnit="cm">
                   <Tags>
                     <Tag value="Lumen" />
                     <Tag value="LumenSegment" />
                   </Tags>
-                  <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
-                  <Info min="0" max="14" flag="122" seq="1" ref="0" bb="32" group="41" />
+                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                </Parameter>
+                <Parameter id="77T0CmRhaEShor0sDnyFRg" name="Thickness_p3" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.10014267" displayUnit="1/cm">
+                  <Tags>
+                    <Tag value="Lumen" />
+                    <Tag value="LumenSegment" />
+                  </Tags>
+                  <Info flag="54" seq="1" ref="0" bb="32" group="45" />
                 </Parameter>
-                <DistributedParameter id="M_eHVWLIH0Kp4UrxUZ52Hw" name="Effective surface area enhancement factor" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TRbL3mYFE0Ohjjm7yC5-TA" mode="Logical" isDefault="1">
+                <DistributedParameter id="Hp0kC0b6j0K4D-SbWAHspw" name="Effective surface area enhancement factor" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="9YrGekFCNUCQCqTI4wvgVw" mode="Logical" isDefault="1">
                   <Children>
-                    <Parameter id="I1oZGDe8mUioPweZJ4Lbzg" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                    <Parameter id="IkVdAd3BfUKK4COZfhvW7Q" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
                       <Info min="0" flag="18" seq="1" ref="0" bb="32" group="32" />
                     </Parameter>
-                    <Parameter id="B-MlQsa0yk-ZjD09yznLRA" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="3.56">
+                    <Parameter id="5eiCv1p0r0qww2WHK8LUVA" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="3.56">
                       <Info min="0" flag="50" seq="1" ref="0" bb="32" group="32" />
                     </Parameter>
                   </Children>
@@ -6157,103 +6207,107 @@
                   </Tags>
                   <Info min="0" flag="122" seq="1" ref="0" bb="32" group="32" />
                 </DistributedParameter>
-                <Container id="REBrg4cvz0ut7d12A7fVeg" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="VY9CD-dryEajgz-5ViCZWA" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                   <Children>
-                    <Parameter id="JI6uGhU5M0uJnNkYdKRI1g" name="Solubility table" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.TableFormulaWithXArgument_SolubilityTable" isDefault="1" displayUnit="mg/l">
-                      <Info min="0" flag="50" seq="1" ref="0" bb="2" group="42" />
-                    </Parameter>
-                    <Parameter id="ey7__8wdNE2hMzyXyoBvpw" name="Solubility_pKa_pH_Factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" isDefault="1">
-                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="18" />
-                    </Parameter>
-                    <Parameter id="T0_HbFg-T0Clp6NJ_5S7Ig" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
-                      <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
-                    </Parameter>
-                    <Parameter id="_hwj-88vAU-RCU6VaDrUlw" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" isDefault="1">
-                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
-                    </Parameter>
-                    <Parameter id="BhzPQEgSgkmg07qCNUIUdg" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" isDefault="1">
-                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
-                    </Parameter>
-                    <Parameter id="GnYoctEQ_UawQtifMlBq1w" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal_GI" isDefault="1">
+                    <Parameter id="B39u0vIthkuQ6uLxCnIX0w" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal_GI" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                     </Parameter>
-                    <Parameter id="oflkDc9Ot0ulKNuy9NBNNw" name="Oral mass absorbed segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" rHSFormula="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_rect" value="0" displayUnit="µmol">
+                    <Parameter id="9XTuCTY9_UyNEz96ml9_3w" name="Oral mass absorbed segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" rHSFormula="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_rect" value="0" displayUnit="µmol">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                     </Parameter>
-                    <Parameter id="JVvht_0hbUKugZpkib2SHA" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                    <Parameter id="sMUteTrOWU-kpDFxEYKEZQ" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                     </Parameter>
-                    <Parameter id="4NtdAkSuz0uwqIYWNRFTKQ" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" isDefault="1">
+                    <Parameter id="SjxiCPjZ-E270ULkuhZCcQ" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="RVDV8f3YXUuwpaRijSlzxw" name="Solubility" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_IntestinalSolubility" isDefault="1" displayUnit="mg/l">
-                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="42" />
+                    <Parameter id="DUgUCdhkfUGCqkjhapkIJg" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="7rsobJQS00iifISUXgEVxg" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" isDefault="1">
+                    <Parameter id="TzQyep-NfkaxVTM2_e2IEg" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="UiniU5l7b0SUtSDCAy2abg" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" isDefault="1">
+                    <Parameter id="HytmX6zFZU6pNxmDfusl8w" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="SI2-_tuKDk2j8EGjILX-4w" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" isDefault="1">
+                    <Parameter id="FZfHX067DkaAc5SU2-wrkw" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="2DnRCVYGrEKWH6fQqT1odw" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" isDefault="1">
+                    <Parameter id="t1V9KRdygECxihHnD-wJBw" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="SQU_BfUQJkS8507SmW3HgQ" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" isDefault="1">
+                    <Parameter id="Ni304-IRwkOj7QA5QVdTsw" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="mdjRsuJdEEWA_tDmR3bIjg" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" isDefault="1">
+                    <Parameter id="hMaZ3Qwz20eU2tazTPcD0A" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="97IzNGXrLUCgCyYxfKGEww" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" isDefault="1">
+                    <Parameter id="EtTjGWvQPkK26lghj5CpSg" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
-                    <Parameter id="QEK9Y5aGuUqyPjOF8dpIyg" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" isDefault="1">
+                    <Parameter id="1oWpHhKwTEyMUibbXavj5Q" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" isDefault="1">
                       <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
                     </Parameter>
+                    <Parameter id="3XyRt8CBb0K_nDww4bCv0g" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                    </Parameter>
+                    <Parameter id="d6t9Lab82Uyt5VUmcfcHQw" name="Solubility" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_IntestinalSolubility" isDefault="1" displayUnit="mg/l">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="42" />
+                    </Parameter>
+                    <Parameter id="qhb8FIpan0uEe2-a6IiDzg" name="Solubility table" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.TableFormulaWithXArgument_SolubilityTable" isDefault="1" displayUnit="mg/l">
+                      <Info min="0" flag="50" seq="1" ref="0" bb="2" group="42" />
+                    </Parameter>
+                    <Parameter id="ZjG3SiEWyE2JG9TINVgUSg" name="Solubility_pKa_pH_Factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" isDefault="1">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="18" />
+                    </Parameter>
+                    <Parameter id="iwtcy1ahwUq-QQ3EXBodNw" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                      <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                    </Parameter>
+                    <Parameter id="rBcTmTsEMEOJ95FaNbViXw" name="Effective concentration in lumen" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_EffectiveLumenConcentration" isDefault="1" displayUnit="µmol/l">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="42" />
+                    </Parameter>
                   </Children>
                 </Container>
               </Children>
             </Container>
-            <Container id="fC_ON9xUFUeYD0_p8R-LbQ" name="Feces" mode="Physical" containerType="Compartment">
+            <Container id="hjYz-UFsdU-eQOKivi16tA" name="Feces" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="Lumen" />
                 <Tag value="LumenSegment" />
               </Tags>
               <Children>
-                <Parameter id="VIV1c-vpQ0iCpkM1qayCgA" name="Liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" rHSFormula="Lumen_PKSim.LiquidRHS_fec" value="0" displayUnit="l">
+                <Parameter id="xcwDgVNCCUqGJpGSRbcDZw" name="Liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" rHSFormula="Lumen_PKSim.LiquidRHS_fec" value="0" displayUnit="l">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
                 </Parameter>
-                <Parameter id="V9QZ_A_lO0W8UHivvkbX6w" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="l">
+                <Parameter id="zGN7VglU6ESwyCiCQHvBsg" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="l">
                   <Info min="0" flag="54" seq="1" ref="0" bb="2" group="56" />
                 </Parameter>
               </Children>
             </Container>
           </Children>
         </Container>
-        <Container id="5NIF0GUMbES8PSzvuJBIyQ" name="Stomach" mode="Logical" containerType="Organ">
+        <Container id="k46ZlWvw6EqsUOh_pKsAlw" name="Stomach" mode="Logical" containerType="Organ">
           <Tags>
             <Tag value="Portal Vein Supplying Organ" />
             <Tag value="TissueOrgan" />
           </Tags>
           <Children>
-            <Parameter id="finBy0ZRiU-wVzAN2iR9Lw" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
+            <Parameter id="bp48p8Uzk0SumQdJgHLXJA" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
             </Parameter>
-            <Parameter id="PkdPd0wJoU6fffkzwJkzoA" name="Volume (endothelium)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="VascularEndoVolume.VOLUME_VascularEndo_sto" isDefault="1" displayUnit="l">
+            <Parameter id="8Ac-hA0LjUaWH5oZmgMwNA" name="Fluid recirculation flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate" isDefault="1" displayUnit="l/min">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
-              <Info min="0" flag="62" seq="14" ref="0" bb="32" group="127" />
+              <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+              <Info min="0" flag="122" seq="14" ref="0" bb="32" group="27" />
             </Parameter>
-            <Parameter id="T9erAQd1d0yIa2uWPRWGaQ" name="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Lymph_flow_rate" isDefault="1" displayUnit="l/min">
+            <Parameter id="AGfvivuI-EqK7pZAwP-JHw" name="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Lymph_flow_rate" isDefault="1" displayUnit="l/min">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
@@ -6261,111 +6315,111 @@
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
               <Info min="0" flag="122" seq="14" ref="0" bb="32" group="58" />
             </Parameter>
-            <Parameter id="Y9fwqwW_i0er6FzgxX0fJw" name="Fluid recirculation flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate" isDefault="1" displayUnit="l/min">
+            <Parameter id="y9oDJGSlRE-_dqJ0tj0M9A" name="Volume (endothelium)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="VascularEndoVolume.VOLUME_VascularEndo_sto" isDefault="1" displayUnit="l">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
-              <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-              <Info min="0" flag="122" seq="14" ref="0" bb="32" group="27" />
+              <Info min="0" flag="62" seq="14" ref="0" bb="32" group="127" />
             </Parameter>
-            <Parameter id="3hThF_BV20mY7uEFW3KHww" name="Fraction intracellular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_f_cell" isDefault="1">
+            <Parameter id="AFKV7mx6vU-F6mkgtAIDWQ" name="Fraction intracellular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_f_cell" isDefault="1">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" max="1" flag="62" seq="43" ref="0" bb="32" group="64" />
             </Parameter>
-            <Parameter id="p01cFCmMCkWY8kzv4V1McQ" name="Blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_from_Qspec" isDefault="1" displayUnit="l/min">
+            <Parameter id="OtgxWesmuUuIYOIqJzyAlg" name="Blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_from_Qspec" isDefault="1" displayUnit="l/min">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
-              <ValueOrigin id="48" description="TODO: Absolute from specific calculation" />
+              <ValueOrigin id="48" source="Other" description="Absolute value = specific value (i.e. value normalized to the volume of the organ) multiplied by the organ volume" />
               <Info min="0" flag="62" seq="262" ref="0" bb="32" group="5" />
             </Parameter>
-            <Parameter id="jqaXF5e3VUGoLk7quse3eg" name="Density (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
+            <Parameter id="RYOMJor4jU-VzUjW9NKMFA" name="Density (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" flag="38" seq="1" ref="0" bb="32" group="21" />
             </Parameter>
-            <Parameter id="iXBbKY2HvUKoQCBh1JYffg" name="Fluid recirculation flow proportionality factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.96">
+            <Parameter id="3hEMRzF4xUOvImenOZKs4g" name="Fluid recirculation flow proportionality factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.96">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" flag="54" seq="1" ref="0" bb="32" group="27" />
             </Parameter>
-            <Parameter id="vJs6wadNB0Csp1fW6MFTLQ" name="Lymph flow proportionality factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.00204">
+            <Parameter id="JfH2_u2mok-tHK5gtXDMTg" name="Lymph flow proportionality factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.00204">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" flag="54" seq="1" ref="0" bb="32" group="58" />
             </Parameter>
-            <Parameter id="-_B6asXfPEiqvGI2-jBzWw" name="Organ volume mouse" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.00011" displayUnit="l">
+            <Parameter id="sZzAB51mc0aNejmhwwllBg" name="Organ volume mouse" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.00011" displayUnit="l">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" flag="54" seq="1" ref="0" bb="32" group="65" />
             </Parameter>
-            <Parameter id="N13wZtNeG0GL2PG9RaHz1Q" name="Allometric scale factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.75">
+            <Parameter id="cy95NaaxAkOhas-SajP52A" name="Allometric scale factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.75">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0.75" max="0.75" flag="54" seq="1" ref="0" bb="32" group="2" />
             </Parameter>
-            <Parameter id="EcJxdbb1XEyl2_MDpIyyGA" name="Fraction of blood for sampling" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+            <Parameter id="SkCw_TvAxkmVn8tfNw1okA" name="Fraction of blood for sampling" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" max="1" flag="54" seq="1" ref="0" bb="32" group="94" />
             </Parameter>
-            <Parameter id="PH7v4W_VrUOsfd3LPqglDg" name="Hydraulic conductivity" icon="Parameter" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="3.97222222222222E-11" displayUnit="ml/min/N">
+            <Parameter id="VAZt37jIPkOp7p6JlQTBbg" name="Flow fraction via large pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.05">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-              <Info min="0" flag="122" seq="14" ref="0" bb="32" group="115" />
+              <Info min="0" max="1" flag="122" seq="14" ref="0" bb="32" group="114" />
             </Parameter>
-            <Parameter id="LEBVtFKXuUu1XRvx4052Yw" name="Flow fraction via large pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.05">
+            <Parameter id="6R-ZF6zlC0SMA-JZOVRgWQ" name="Hydraulic conductivity" icon="Parameter" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="3.97222222222222E-11" displayUnit="ml/min/N">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-              <Info min="0" max="1" flag="122" seq="14" ref="0" bb="32" group="114" />
+              <Info min="0" flag="122" seq="14" ref="0" bb="32" group="115" />
             </Parameter>
-            <Parameter id="_fbkQQTL8Eu5XghQzlKZhA" name="Radius (small pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="4.5E-08" displayUnit="µm">
+            <Parameter id="Wg_ifFBjrEuZxexjSL5uPA" name="Radius (large pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.5E-07" displayUnit="µm">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-              <Info min="0" flag="122" seq="14" ref="0" bb="32" group="99" />
+              <Info min="0" flag="122" seq="14" ref="0" bb="32" group="55" />
             </Parameter>
-            <Parameter id="Kj8mKG_jl0K8Fb8YzxYccA" name="Radius (large pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.5E-07" displayUnit="µm">
+            <Parameter id="3osoE1hjSUKmRcVU2AgQXA" name="Radius (small pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="4.5E-08" displayUnit="µm">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-              <Info min="0" flag="122" seq="14" ref="0" bb="32" group="55" />
+              <Info min="0" flag="122" seq="14" ref="0" bb="32" group="99" />
             </Parameter>
-            <Parameter id="dn0dXpiFT02TYZDs7EiJTg" name="Vf (neutral lipid)-PT" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0487">
+            <Parameter id="xRVjMmDPY0yWngGvB3pGOw" name="Fraction vascular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.032">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
-              <Info min="0" max="1" flag="122" seq="42" ref="0" bb="32" group="86" />
+              <ValueOrigin id="19" source="Publication" description="Kawai R, Lemaire M, Steimer JL, Bruelisauer A, Niederberger W, Rowland M. Physiologically based pharmacokinetic study on a cyclosporin derivative, SDZ IMM 125. J Pharmacokinet Biopharm. 1994 Oct;22(5):327-65." />
+              <Info min="0" max="1" flag="62" seq="42" ref="0" bb="32" group="64" />
             </Parameter>
-            <Parameter id="gGzobbFDwkWsE5R13SZDEg" name="Vf (lipid)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.062">
+            <Parameter id="xsKms5ezQEe2HCn2pHDIcg" name="Vf (lipid)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.062">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
@@ -6373,37 +6427,37 @@
               <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
               <Info min="0" max="1" flag="122" seq="42" ref="0" bb="32" group="85" />
             </Parameter>
-            <Parameter id="kOJENhVyyk-_8NKNLdE55Q" name="Fraction vascular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.032">
+            <Parameter id="2-P00it130a_TdQKtNl41Q" name="Vf (neutral lipid)-PT" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0487">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
-              <ValueOrigin id="19" source="Publication" description="Kawai R, Lemaire M, Steimer JL, Bruelisauer A, Niederberger W, Rowland M. Physiologically based pharmacokinetic study on a cyclosporin derivative, SDZ IMM 125. J Pharmacokinet Biopharm. 1994 Oct;22(5):327-65." />
-              <Info min="0" max="1" flag="62" seq="42" ref="0" bb="32" group="64" />
+              <Info min="0" max="1" flag="122" seq="42" ref="0" bb="32" group="86" />
             </Parameter>
-            <Parameter id="WFeG8IwG20Oe_fOwi7bfhw" name="Vf (protein)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.133">
+            <Parameter id="PKwd5IxaAECggkA1WatEYA" name="Vf (phospholipid)-PT" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0163">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
-              <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
-              <Info min="0" max="1" flag="122" seq="43" ref="0" bb="32" group="85" />
+              <Info min="0" max="1" flag="122" seq="43" ref="0" bb="32" group="86" />
             </Parameter>
-            <Parameter id="GdYEDLYFe0CyzAU5FKHr_w" name="Vf (phospholipid)-PT" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0163">
+            <Parameter id="YjYRZdLHGkei-a2ks4C7MA" name="Vf (protein)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.133">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
-              <Info min="0" max="1" flag="122" seq="43" ref="0" bb="32" group="86" />
+              <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
+              <Info min="0" max="1" flag="122" seq="43" ref="0" bb="32" group="85" />
             </Parameter>
-            <Parameter id="41_xFiDIsUCSfm0rsmfuSQ" name="Vf (water)-PT" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.718">
+            <Parameter id="5BJlV2E13Eupb_PpWIihSA" name="Fraction interstitial" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.1">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
-              <Info min="0" max="1" flag="122" seq="44" ref="0" bb="32" group="86" />
+              <ValueOrigin id="19" source="Publication" description="Kawai R, Lemaire M, Steimer JL, Bruelisauer A, Niederberger W, Rowland M. Physiologically based pharmacokinetic study on a cyclosporin derivative, SDZ IMM 125. J Pharmacokinet Biopharm. 1994 Oct;22(5):327-65." />
+              <Info min="0" max="1" flag="62" seq="44" ref="0" bb="32" group="64" />
             </Parameter>
-            <Parameter id="nhLxuUQZg0eGIsdqRbtspA" name="Albumin ratio (tissue/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.158">
+            <Parameter id="NUC6chywJ0m9r5HymiFfhw" name="Albumin ratio (tissue/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.158">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
@@ -6411,7 +6465,7 @@
               <ValueOrigin id="22" source="Publication" description="Rodgers T, Rowland M. Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J Pharm Sci. 2006 Jun;95(6):1238-57 https://doi.org/10.1002/jps.20502" />
               <Info min="0" max="1" flag="122" seq="44" ref="0" bb="32" group="111" />
             </Parameter>
-            <Parameter id="Kpu5yWSwrEWFplytWSY_sg" name="Albumin ratio (tissue/plasma)-PT" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+            <Parameter id="57LcSfGIUEi4NnJtWzdAKA" name="Albumin ratio (tissue/plasma)-PT" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
@@ -6419,7 +6473,7 @@
               <ValueOrigin id="24" source="Publication" description="POULIN P, THEIL F. Prediction of Pharmacokinetics Prior to In Vivo Studies. 1. Mechanism-Based Prediction of Volume of Distribution. JOURNAL OF PHARMACEUTICAL SCIENCES, VOL. 91, NO. 1, JANUARY 2002" />
               <Info min="0" max="1" flag="122" seq="44" ref="0" bb="32" group="112" />
             </Parameter>
-            <Parameter id="-astFVNIj0S_6vVtMjWDHw" name="Lipoprotein ratio (tissue/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.141">
+            <Parameter id="iFBms3g7T0GGwyi05fLEmQ" name="Lipoprotein ratio (tissue/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.141">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
@@ -6427,7 +6481,7 @@
               <ValueOrigin id="22" source="Publication" description="Rodgers T, Rowland M. Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J Pharm Sci. 2006 Jun;95(6):1238-57 https://doi.org/10.1002/jps.20502" />
               <Info min="0" max="1" flag="122" seq="44" ref="0" bb="32" group="113" />
             </Parameter>
-            <Parameter id="ppi-_vQOgEuhWLvNQ05SVQ" name="Vf (water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.792">
+            <Parameter id="Jrl3AH5btUeyBCbI1-5jEg" name="Vf (water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.792">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
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+            <Parameter id="LbtygTsfaki4aKmjR7i4VQ" name="Vf (extracellular water)-RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.282">
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+            <Parameter id="nSujQnRlSkWDbUagYlWVlg" name="Acidic phospholipids [mg/g] - RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.41">
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                 <Tag value="TissueOrgan" />
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+                <Parameter id="WUwje6jjxU-DNUpSQ6jCqg" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.500579954845" displayUnit="l">
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+                <Parameter id="JXAv2TVPoUKL6Ojau2Jvrg" name="Deviation" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.025271500392" displayUnit="l">
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@@ -6534,17 +6587,18 @@
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                 <Tag value="TissueOrgan" />
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+            <DistributedParameter id="WoKrWxFpAE-97zS-IkTqBg" name="Specific blood flow rate" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" formula="eg3rlcfH-Eywh_HZ2JKh7A" mode="Logical" isDefault="1" displayUnit="ml/min/100g organ">
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+                <Parameter id="4ZHl-uZrMEehpmOLBOJR0Q" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5" displayUnit="ml/min/100g organ">
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+                <Parameter id="BoLp2PvQtkmZaY5th88C2w" name="Deviation" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.019305" displayUnit="ml/min/100g organ">
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@@ -6552,128 +6606,129 @@
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
+              <ValueOrigin id="40" source="Publication" description="Edginton, A.N., Schmitt, W. &amp; Willmann, S. Clin Pharmacokinet (2006) 45: 1013. https://doi.org/10.2165/00003088-200645100-00005" />
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             </DistributedParameter>
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                 <Tag value="Portal Vein Supplying Organ" />
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+                <Parameter id="Sqd2ZOzxREOaCWJGvAo4Zg" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
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+                <Parameter id="e8BAESFHUUG-pWiM9ixnHw" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" isDefault="1" displayUnit="l">
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                 </Parameter>
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+                    <Parameter id="5n6Pz1XOf0efU5w5njqY5w" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" isDefault="1">
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+                    <Parameter id="hDsd-ezcD0at4w8C2qHASA" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
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+            <Container id="AVrkjZHVYE2BekZ0hnC4Wg" name="BloodCells" mode="Physical" containerType="Compartment">
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                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="Stomach" />
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+                <Parameter id="qOCPYD2cs02cj__c3uxZaw" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" isDefault="1" displayUnit="l">
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                 </Parameter>
-                <Container id="56AcYwy--Ey2Jvzf4BvEqw" name="MoleculeProperties" mode="Logical" containerType="Molecule">
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+                    <Parameter id="_gJEvD_WcUCptY8oZzV06w" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
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+                    <Parameter id="3MoVZzsKEUC_L8ligzuo-g" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" isDefault="1">
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+                    <Parameter id="4X9URNmslkmM2V8N7qCNnA" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
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               </Children>
             </Container>
-            <Container id="QmDulSYPKUeL8N3K5vwsYQ" name="Interstitial" mode="Physical" containerType="Compartment">
+            <Container id="_GvqcoaP4k2UJRR2NiaDGg" name="Interstitial" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="Stomach" />
               </Tags>
               <Children>
-                <Parameter id="JO5k6Ge3m0CjxKthPxD_OA" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                <Parameter id="wuYE1Ih3KEuxzMRnWH8K9w" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
                   <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                 </Parameter>
-                <Parameter id="5PYxghwlJESABzElb1q4rQ" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" isDefault="1" displayUnit="l">
+                <Parameter id="nN40miRqi0Shfol6apXmXw" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" isDefault="1" displayUnit="l">
                   <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                   <Info min="0" flag="62" seq="14" ref="0" bb="2" group="124" />
                 </Parameter>
-                <Parameter id="vwYSGCrwjEWkoi83CEwlGg" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_pH_INT" isDefault="1">
+                <Parameter id="10uYEm0-rUKIeEwtMKtSxQ" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_pH_INT" isDefault="1">
                   <Tags>
                     <Tag value="Portal Vein Supplying Organ" />
                     <Tag value="Stomach" />
                   </Tags>
                   <Info min="0" max="14" flag="122" seq="44" ref="0" bb="32" group="84" />
                 </Parameter>
-                <Container id="6pPv67miOEisATvGpJ1W0g" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="TTM-sf7ROkSz-RF9fC5WnA" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                   <Children>
-                    <Parameter id="GJd1VDKyMkOyjN69xtzeCg" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                    <Parameter id="FH0GO2GcY0aGMmkhGBy16w" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                     </Parameter>
-                    <Parameter id="26JFkYf4TU-EIxEjwTS4YQ" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
-                      <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
-                    </Parameter>
-                    <Parameter id="W86lvcK3jUSo7wLqaW2tUw" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_sto" isDefault="1">
+                    <Parameter id="ssOwzJwvfEKndxTFJpEiJA" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_sto" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                     </Parameter>
+                    <Parameter id="vI-UyrGi1UepGAselJIqvw" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
+                      <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                    </Parameter>
                   </Children>
                 </Container>
               </Children>
             </Container>
-            <Container id="iTYIG51yM0ihvhyZ_3uPyQ" name="Intracellular" mode="Physical" containerType="Compartment">
+            <Container id="cE5Vh4PDM0yzMt6k1l_McQ" name="Intracellular" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="Stomach" />
               </Tags>
               <Children>
-                <Parameter id="X6wxznaTvE2C0U_zX8-NBQ" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" isDefault="1" displayUnit="l">
+                <Parameter id="TB2qRX0wf0q1i9DJervDDg" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" isDefault="1" displayUnit="l">
                   <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                 </Parameter>
-                <Parameter id="5qXUcQrI-kGDoYoqghovgg" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" isDefault="1" displayUnit="l">
+                <Parameter id="KEuEx87xV0yQKXXcNIdrcw" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" isDefault="1" displayUnit="l">
                   <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                   <Info min="0" flag="62" seq="14" ref="0" bb="2" group="125" />
                 </Parameter>
-                <Parameter id="C4_sA-k2O02v2iUy3btQYg" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.4">
+                <Parameter id="uDsQEDtVp0uEZu7s3iSq4g" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.4">
                   <Tags>
                     <Tag value="Portal Vein Supplying Organ" />
                     <Tag value="Stomach" />
                   </Tags>
                   <Info min="0" max="14" flag="122" seq="44" ref="0" bb="32" group="83" />
                 </Parameter>
-                <Container id="XXTo7JXEXU2Iyic5qT4FPA" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="ZkHOTBpXtU-MZTmCmeDdPQ" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                   <Children>
-                    <Parameter id="mNgPLjYXLUar1wTA4mBxhQ" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                    <Parameter id="dLBTZ4CiaUGgQ9l19drMAg" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                     </Parameter>
-                    <Parameter id="ZoasE7d6VESSqeSaAvh5fQ" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_sto" isDefault="1">
+                    <Parameter id="OZXAni0PIEKGiyVsvYo6Kg" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_sto" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                     </Parameter>
-                    <Parameter id="nXU9SkNdbEWjLwSnfQCLJg" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
+                    <Parameter id="LZMauBXfEEK0P_FeOB6FyQ" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
                       <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                     </Parameter>
                   </Children>
@@ -6682,27 +6737,27 @@
             </Container>
           </Children>
         </Container>
-        <Container id="sy_28Js9VkueROEQScrvcA" name="SmallIntestine" mode="Logical" containerType="Organ">
+        <Container id="KqDCWQdAgEeMBAmJnvyVqw" name="SmallIntestine" mode="Logical" containerType="Organ">
           <Tags>
             <Tag value="Portal Vein Supplying Organ" />
             <Tag value="TissueOrgan" />
           </Tags>
           <Children>
-            <Parameter id="3EUXUIP1LU61jfwIuq7Qdw" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
+            <Parameter id="eMEProwSs02KbrENgKJhww" name="Small intestinal transit time factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_SITT_Factor" isDefault="1">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
-              <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
+              <Info min="0" flag="38" seq="1" ref="0" bb="32" group="46" />
             </Parameter>
-            <Parameter id="FjdWxdOGWk6oc3cDKkPyYA" name="Small intestinal transit time factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_SITT_Factor" isDefault="1">
+            <Parameter id="zSQz9OlX80Sp0T-QpOsGAw" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
-              <Info min="0" flag="38" seq="1" ref="0" bb="32" group="46" />
+              <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
             </Parameter>
-            <Parameter id="3vynfgkGMEKwONSWNZeavg" name="Fluid recirculation flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_FluidRecirculationRate_sin" isDefault="1" displayUnit="l/min">
+            <Parameter id="xJVTxGTCOk2RrBjd-c1g6w" name="Fluid recirculation flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_FluidRecirculationRate_sin" isDefault="1" displayUnit="l/min">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
@@ -6710,123 +6765,123 @@
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
               <Info min="0" flag="62" seq="15" ref="0" bb="32" group="27" />
             </Parameter>
-            <Parameter id="XWyLtKzY8UC_w14_SAItCQ" name="Volume (endothelium)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="VascularEndoVolume.VOLUME_VascularEndo_sin" isDefault="1" displayUnit="l">
+            <Parameter id="TP-J57w51UGz8UudG-P70g" name="Fluid recirculation flow rate (incl. mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate" isDefault="1" displayUnit="l/min">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
-              <Info min="0" flag="62" seq="15" ref="0" bb="32" group="127" />
+              <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+              <Info min="0" flag="122" seq="15" ref="0" bb="32" group="27" />
             </Parameter>
-            <Parameter id="RGqWv7-awEWh5HcH37fPyw" name="Fluid recirculation flow rate (incl. mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate" isDefault="1" displayUnit="l/min">
+            <Parameter id="j9OxCNGZEEmatKvkXdojgQ" name="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_Lymph_sin" isDefault="1" displayUnit="l/min">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-              <Info min="0" flag="122" seq="15" ref="0" bb="32" group="27" />
+              <Info min="0" flag="62" seq="15" ref="0" bb="32" group="58" />
             </Parameter>
-            <Parameter id="b_5o7LlrTEi-zrYqwFLxDw" name="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_Lymph_sin" isDefault="1" displayUnit="l/min">
+            <Parameter id="UdpZ7uw1RE-00m1WjeKQwA" name="Lymph flow rate (incl. mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Lymph_flow_rate" isDefault="1" displayUnit="l/min">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-              <Info min="0" flag="62" seq="15" ref="0" bb="32" group="58" />
+              <Info min="0" flag="122" seq="15" ref="0" bb="32" group="58" />
             </Parameter>
-            <Parameter id="1ilGb4nEY0OsgflHoF3P5w" name="Lymph flow rate (incl. mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Lymph_flow_rate" isDefault="1" displayUnit="l/min">
+            <Parameter id="4TB3XaZuvUSgixhloL6hIg" name="Volume (endothelium)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="VascularEndoVolume.VOLUME_VascularEndo_sin" isDefault="1" displayUnit="l">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
-              <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-              <Info min="0" flag="122" seq="15" ref="0" bb="32" group="58" />
+              <Info min="0" flag="62" seq="15" ref="0" bb="32" group="127" />
             </Parameter>
-            <Parameter id="xkVlMueZLUOfjtAq8qfPCQ" name="Fraction intracellular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_f_cell" isDefault="1">
+            <Parameter id="Zou5_YpDFk2zyPRIreTt4A" name="Fraction intracellular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_f_cell" isDefault="1">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" max="1" flag="62" seq="46" ref="0" bb="32" group="64" />
             </Parameter>
-            <Parameter id="b1eC7HLyLEWfOH5hdKd8Lw" name="Blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_from_Qspec" isDefault="1" displayUnit="l/min">
+            <Parameter id="1Tvs9OZvm0O53WhSY5LLJA" name="Blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_from_Qspec" isDefault="1" displayUnit="l/min">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
-              <ValueOrigin id="48" description="TODO: Absolute from specific calculation" />
+              <ValueOrigin id="48" source="Other" description="Absolute value = specific value (i.e. value normalized to the volume of the organ) multiplied by the organ volume" />
               <Info min="0" flag="62" seq="222" ref="0" bb="32" group="5" />
             </Parameter>
-            <Parameter id="buGe-Rw-pE6WDBZxeWj5cA" name="Volume (mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="MucosaVolume.VOLUME_SmallIntestineMucosa" isDefault="1" displayUnit="l">
+            <Parameter id="9vLB6djQ706rljJ6u0wYXQ" name="Volume (mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="MucosaVolume.VOLUME_SmallIntestineMucosa" isDefault="1" displayUnit="l">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" flag="62" seq="666" ref="0" bb="32" group="129" />
             </Parameter>
-            <Parameter id="Ri8aun9ljUaDwGN_IkCzjw" name="Organ volume mouse" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.001406" displayUnit="l">
+            <Parameter id="QTCdRafg4E-EMCpb4bNMow" name="Density (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
-              <Info min="0" flag="54" seq="1" ref="0" bb="32" group="65" />
+              <Info min="0" flag="38" seq="1" ref="0" bb="32" group="21" />
             </Parameter>
-            <Parameter id="iskahn1kyEaHukjmSfxalw" name="Density (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
+            <Parameter id="udcSoSlr7EeWnN99iVdthg" name="Fluid recirculation flow proportionality factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.179">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
-              <Info min="0" flag="38" seq="1" ref="0" bb="32" group="21" />
+              <Info min="0" flag="54" seq="1" ref="0" bb="32" group="27" />
             </Parameter>
-            <Parameter id="fYyJBRCS20iGUYpMXk4GbA" name="Lymph flow proportionality factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.00195">
+            <Parameter id="25ARM3zzhUKyBSLfzCOXqQ" name="Lymph flow proportionality factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.00195">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" flag="54" seq="1" ref="0" bb="32" group="58" />
             </Parameter>
-            <Parameter id="gQ9Pf4yNwUG4m1G1KQEbIQ" name="Fluid recirculation flow proportionality factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.179">
+            <Parameter id="HhgA6sxRY0mI79MpZJekhg" name="Organ volume mouse" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.001406" displayUnit="l">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
-              <Info min="0" flag="54" seq="1" ref="0" bb="32" group="27" />
+              <Info min="0" flag="54" seq="1" ref="0" bb="32" group="65" />
             </Parameter>
-            <Parameter id="DWAElsCjWk6gEegSS-4X0A" name="Allometric scale factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.75">
+            <Parameter id="Gc_rCcTgYU-isy0xVcAmMQ" name="Allometric scale factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.75">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0.75" max="0.75" flag="54" seq="1" ref="0" bb="32" group="2" />
             </Parameter>
-            <Parameter id="guroZpUxPUmSwxTJm61VTQ" name="Small intestinal transit time factor slope" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.602" displayUnit="1/min">
+            <Parameter id="-i_E6BZnSEuhgszvzIB6Rw" name="Mucosa blood flow fraction" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.75">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
-              <Info flag="52" seq="1" ref="0" bb="32" group="46" />
+              <Info min="0" flag="54" seq="1" ref="0" bb="32" group="39" />
             </Parameter>
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-            <Parameter id="X5gOZHxnQUS_6qLe-rV0Kw" name="Vf (water)-WS" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.78">
+            <Parameter id="Awz9vJA9f0qXxnDddsCttQ" name="Vf (water)-WS" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.78">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" max="1" flag="122" seq="78" ref="0" bb="32" group="95" />
             </Parameter>
-            <Parameter id="k-fav71ttE2oI8tLEvCtaA" name="Acidic phospholipids [mg/g] - RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.41">
+            <Parameter id="Mp7lbWnXCE6IDE5XOs5Ywg" name="Acidic phospholipids [mg/g] - RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.41">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
@@ -7011,22 +7066,22 @@
               <ValueOrigin id="21" source="Publication" description="Rodgers T, Leahy D, Rowland M. Physiologically based pharmacokinetic modeling 1: predicting the tissue distribution of moderate-to-strong bases. J Pharm Sci. 2005 Jun;94(6):1259-76. https://doi.org/10.1002/jps.20322" />
               <Info min="0" max="1000" flag="122" seq="79" ref="0" bb="32" group="92" />
             </Parameter>
-            <Parameter id="eqg-lcsvtk2rSxNkNlDgoA" name="Vf (acidic phospholipids)-WS" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0035">
+            <Parameter id="6pS8W20FdEyr4Ws9vXI5Hg" name="Vf (acidic phospholipids)-WS" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0035">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" max="1" flag="122" seq="79" ref="0" bb="32" group="95" />
             </Parameter>
-            <DistributedParameter id="i8SwOn5vMUODO-6568_W8g" name="Small intestinal transit time" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="PRnKaq-TqkqXAmhTzsS1_w" mode="Logical" isDefault="1" displayUnit="h">
+            <DistributedParameter id="iU1mnhpzsU-WqHEV8fHpIw" name="Small intestinal transit time" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="Ntf3OfXk5UKsh42ogIeArw" mode="Logical" isDefault="1" displayUnit="h">
               <Children>
-                <Parameter id="0ZG6IaANVk6uNeYbI4-YeQ" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5" displayUnit="h">
+                <Parameter id="agMY4QGgRUinnJwQwFK65Q" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5" displayUnit="h">
                   <Info min="0" flag="18" seq="1" ref="0" bb="32" group="46" />
                 </Parameter>
-                <Parameter id="lzjht5VwT0ibhuyHRgPjcw" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="126" displayUnit="h">
+                <Parameter id="dPxazS8eNES0ZdA36stdBg" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="126" displayUnit="h">
                   <Info min="27.2" max="1200" flag="50" seq="1" ref="0" bb="32" group="46" />
                 </Parameter>
-                <Parameter id="mgBOyIAld0K1HRowlGSnRA" name="GeometricDeviation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.6">
+                <Parameter id="dzqJ04WBOUGPvAzYwjvh4Q" name="GeometricDeviation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.6">
                   <Info min="1" flag="18" seq="1" ref="0" bb="32" group="46" />
                 </Parameter>
               </Children>
@@ -7036,15 +7091,15 @@
               </Tags>
               <Info min="27.2" max="1200" flag="122" seq="1" ref="0" bb="32" group="46" />
             </DistributedParameter>
-            <DistributedParameter id="qMXuqhar30qcsjPpJNMC_Q" name="Volume" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="WqNJssMjMkid-DRMeJvbAA" mode="Logical" isDefault="1" displayUnit="l">
+            <DistributedParameter id="4XJ_qexvkE2D6F9Q4TkllQ" name="Volume" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="M3wOzq6yIkiDNg1txpsC9g" mode="Logical" isDefault="1" displayUnit="l">
               <Children>
-                <Parameter id="Uv6ES5dRO0u87K9uYqeolQ" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.501982847112672" displayUnit="l">
+                <Parameter id="Sg14QaqTX02EDxiSZIh7Ig" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.502575498213435" displayUnit="l">
                   <Info min="0" flag="18" seq="1" ref="0" bb="32" group="65" />
                 </Parameter>
-                <Parameter id="taDhE5LSfEO1jUSYqd4iqQ" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.58335271881664" displayUnit="l">
+                <Parameter id="Nt32KvpomU2-FYQFW4jxgw" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.7240974816" displayUnit="l">
                   <Info min="0" flag="34" seq="1" ref="0" bb="32" group="65" />
                 </Parameter>
-                <Parameter id="0kQTckkbUEOsrxG0VhIkSw" name="Deviation" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0682572317087829" displayUnit="l">
+                <Parameter id="a51_UXog6kKuxqqjrtNgpA" name="Deviation" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.084725566517592" displayUnit="l">
                   <Info min="0" flag="18" seq="1" ref="0" bb="32" group="65" />
                 </Parameter>
               </Children>
@@ -7052,17 +7107,18 @@
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
+              <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
               <Info min="0" flag="106" seq="16" ref="0" bb="32" group="65" />
             </DistributedParameter>
-            <DistributedParameter id="BxXcBoukHkaMxlSTTMOx9A" name="Specific blood flow rate" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" formula="r-D0xmhNEkuhtuwCUNCnnw" mode="Logical" isDefault="1" displayUnit="ml/min/100g organ">
+            <DistributedParameter id="UWA3ri24VE2mebjOPVrJwg" name="Specific blood flow rate" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" formula="CAwhsa2ZvEqxbEHO9r-kyw" mode="Logical" isDefault="1" displayUnit="ml/min/100g organ">
               <Children>
-                <Parameter id="PwqavKQbsEeDUz3UpJJYXA" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5" displayUnit="ml/min/100g organ">
+                <Parameter id="AjuIVfTkJ0KOSXIl4JV5wQ" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5" displayUnit="ml/min/100g organ">
                   <Info min="0" flag="18" seq="1" ref="0" bb="32" group="5" />
                 </Parameter>
-                <Parameter id="QBG8BP6ksEuD4ltikg-SuQ" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.89765" displayUnit="ml/min/100g organ">
+                <Parameter id="YcfCe_UCREeMr9DekMR66A" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.89765" displayUnit="ml/min/100g organ">
                   <Info min="0" flag="50" seq="1" ref="0" bb="32" group="5" />
                 </Parameter>
-                <Parameter id="6GCpSJZ1wU2adc8nEZkxkg" name="Deviation" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0448825" displayUnit="ml/min/100g organ">
+                <Parameter id="gRbJb9xqukeCoW_c-WEhHA" name="Deviation" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0448825" displayUnit="ml/min/100g organ">
                   <Info min="0" flag="18" seq="1" ref="0" bb="32" group="5" />
                 </Parameter>
               </Children>
@@ -7070,338 +7126,339 @@
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
+              <ValueOrigin id="40" source="Publication" description="Edginton, A.N., Schmitt, W. &amp; Willmann, S. Clin Pharmacokinet (2006) 45: 1013. https://doi.org/10.2165/00003088-200645100-00005" />
               <Info min="0" flag="122" seq="221" ref="0" bb="32" group="5" />
             </DistributedParameter>
-            <Container id="YZG2svoXwkCXDQCWhthiGQ" name="Plasma" mode="Physical" containerType="Compartment">
+            <Container id="Vxis-jG0SEele2dNhDDVJg" name="Plasma" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="SmallIntestine" />
               </Tags>
               <Children>
-                <Parameter id="YMwmQHtKaUK5c68GmBhgRQ" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                <Parameter id="KugSsDEeCEalzuZgtYlbzA" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
                   <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                 </Parameter>
-                <Parameter id="lOyA86_aSUywULOqh0LVFQ" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_pls_SinLin" isDefault="1" displayUnit="l">
+                <Parameter id="ij0CqL40vUu_S4aJi_xOqA" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_pls_SinLin" isDefault="1" displayUnit="l">
                   <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
                   <Info min="0" flag="62" seq="15" ref="0" bb="2" group="126" />
                 </Parameter>
-                <Container id="U6C1xMw1tUKVct5UUMZHIA" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="phwTAzZR702FI91kWtJf9w" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                   <Children>
-                    <Parameter id="MO51ts23Mku9CsUJDgJrSA" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                    <Parameter id="GDB4IJXIBE2xtVwPn4Rxpg" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                     </Parameter>
-                    <Parameter id="XFSbzKt7eEqROtMyB5mpwA" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" isDefault="1">
+                    <Parameter id="JZ79UmOkakaXs_GhPPQcaw" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                     </Parameter>
-                    <Parameter id="-G_6vX5jAEK61D3agnkk-w" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
+                    <Parameter id="SSb8r4qdxE6CHI2SlvIwaQ" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
                       <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                     </Parameter>
                   </Children>
                 </Container>
               </Children>
             </Container>
-            <Container id="vQgDb52aoEiJZGHfzZ8xhA" name="BloodCells" mode="Physical" containerType="Compartment">
+            <Container id="dh_9PrSgd0KpJxAtQiKHRw" name="BloodCells" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="SmallIntestine" />
               </Tags>
               <Children>
-                <Parameter id="jFYOBH0TE0iKr19rZWtrVg" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                <Parameter id="mY_SpPEkJEGoNnp-iYXZSQ" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
                   <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                 </Parameter>
-                <Parameter id="eqbCk2eVg0OA8QPHNMP0KQ" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_bc_SinLin" isDefault="1" displayUnit="l">
+                <Parameter id="uCa7AdCoFUKEs5vjo17M6g" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_bc_SinLin" isDefault="1" displayUnit="l">
                   <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
                   <Info min="0" flag="62" seq="15" ref="0" bb="2" group="121" />
                 </Parameter>
-                <Container id="MzHMUSP8iUu9UrUC6h7KJQ" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="ATyJhoVX20GxdNkf0wSzZQ" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                   <Children>
-                    <Parameter id="HZBqk_GGbkyozc7uIObI1A" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                    <Parameter id="JBUwNmGDOEi7neh3slYosw" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                     </Parameter>
-                    <Parameter id="cMKERhgdoEqZeqMATns7MA" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" isDefault="1">
+                    <Parameter id="I556skgn2U2rH7glNP3j4Q" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                     </Parameter>
-                    <Parameter id="mS8DjOIbx0ary1fxcAQxog" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
+                    <Parameter id="4-YQyj0h20CKXb1Y7kxqyg" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
                       <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                     </Parameter>
                   </Children>
                 </Container>
               </Children>
             </Container>
-            <Container id="mwMZ0jijgU2vkDqBsz5f8A" name="Interstitial" mode="Physical" containerType="Compartment">
+            <Container id="0jJslYrVHUKN8OMs3US0yQ" name="Interstitial" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="SmallIntestine" />
               </Tags>
               <Children>
-                <Parameter id="tQc2c_o05ESRf31rhqKMpw" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                <Parameter id="FfPa1_aauUmTPTW8WjxRGQ" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
                   <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                 </Parameter>
-                <Parameter id="9y-vBFAUsUCaZFXdgBVTQw" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_int_SinLin" isDefault="1" displayUnit="l">
+                <Parameter id="n9Heavw4TU-Udb9MkylG7Q" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_int_SinLin" isDefault="1" displayUnit="l">
                   <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
                   <Info min="0" flag="62" seq="15" ref="0" bb="2" group="124" />
                 </Parameter>
-                <Parameter id="2CotdfSIs0Oxic6GbhNCZg" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_pH_INT" isDefault="1">
+                <Parameter id="jp5HSYEj5kGXt-tR4Xq1wA" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_pH_INT" isDefault="1">
                   <Tags>
                     <Tag value="Portal Vein Supplying Organ" />
                     <Tag value="SmallIntestine" />
                   </Tags>
                   <Info min="0" max="14" flag="122" seq="47" ref="0" bb="32" group="84" />
                 </Parameter>
-                <Container id="6IB29fY1VkyFD8vQv8xd6g" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="6yU7ovN-UUSM2NATgwbe6Q" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                   <Children>
-                    <Parameter id="rK9Z7DTKvEeRWedj7MFMyA" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
-                      <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
-                    </Parameter>
-                    <Parameter id="fyceF6v7kEakqfkRH8PZVg" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                    <Parameter id="A2E5keDz0Ee5gMW8FySOCA" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                     </Parameter>
-                    <Parameter id="qPL4OqZYGEmREV3wisWKKw" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_sin" isDefault="1">
+                    <Parameter id="nXiBD0l5hUubIiRhBeb5-A" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_sin" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                     </Parameter>
+                    <Parameter id="URfTkMSyfUOsPuwdsyzWFw" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
+                      <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                    </Parameter>
                   </Children>
                 </Container>
               </Children>
             </Container>
-            <Container id="li-IdicLPU-eIN6uyUmUww" name="Intracellular" mode="Physical" containerType="Compartment">
+            <Container id="1pSz8VtjLEut64GUYnknDg" name="Intracellular" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="SmallIntestine" />
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-                    </Parameter>
-                    <Parameter id="G2N86iYamkyzCcAJejnLIg" name="Vf (neutral lipid)-RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0375">
+                    <Parameter id="9QtSlZlmfkKNEw8E6Z8lFw" name="Vf (neutral lipid)-RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0375">
                       <ValueOrigin id="22" source="Publication" description="Rodgers T, Rowland M. Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J Pharm Sci. 2006 Jun;95(6):1238-57 https://doi.org/10.1002/jps.20502" />
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                     </Parameter>
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+                    <Parameter id="3Df37hsBCkKmLXZZsyDHuA" name="Vf (neutral lipid)-WS" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0483">
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+                    </Parameter>
+                    <Parameter id="KRroHDtSMkayY1rjFToalw" name="Vf (neutral phospholipid)-RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0124">
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                       <Info min="0" max="1" flag="122" seq="556" ref="0" bb="32" group="92" />
                     </Parameter>
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+                    <Parameter id="dme-caQqVUWNTE2UjakYbg" name="Vf (neutral phospholipid, plasma)-WS" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0182">
                       <Info min="0" max="1" flag="122" seq="556" ref="0" bb="32" group="95" />
                     </Parameter>
-                    <Parameter id="K1uGuz2FHESUmW1xIY2z2Q" name="Vf (protein)-WS" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.15">
-                      <Info min="0" max="1" flag="122" seq="557" ref="0" bb="32" group="95" />
-                    </Parameter>
-                    <Parameter id="YGcTMvEJaUKltxvBhqKIFw" name="Vf (extracellular water)-RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.282">
+                    <Parameter id="Jy9vQxKQSEOdzlpoYrJclg" name="Vf (extracellular water)-RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.282">
                       <ValueOrigin id="21" source="Publication" description="Rodgers T, Leahy D, Rowland M. Physiologically based pharmacokinetic modeling 1: predicting the tissue distribution of moderate-to-strong bases. J Pharm Sci. 2005 Jun;94(6):1259-76. https://doi.org/10.1002/jps.20322" />
                       <Info min="0" max="1" flag="122" seq="557" ref="0" bb="32" group="92" />
                     </Parameter>
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+                    <Parameter id="I2LMUpozU0W4uHeV-T80zw" name="Vf (protein)-WS" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.15">
+                      <Info min="0" max="1" flag="122" seq="557" ref="0" bb="32" group="95" />
+                    </Parameter>
+                    <Parameter id="RYBgjrQ1p0KouN2uUExoEA" name="Vf (intracellular water)-RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.456">
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                       <Info min="0" max="1" flag="122" seq="558" ref="0" bb="32" group="92" />
                     </Parameter>
-                    <Parameter id="7zf2Kna8EEy--AF_NbyxcA" name="Vf (water)-WS" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.78">
+                    <Parameter id="F9PzlIGSA0WrBxtFLotIuA" name="Vf (water)-WS" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.78">
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                     </Parameter>
-                    <Parameter id="p-KHhE1bbUSGjRTnYW2nKA" name="Vf (acidic phospholipids)-WS" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0035">
-                      <Info min="0" max="1" flag="122" seq="559" ref="0" bb="32" group="95" />
-                    </Parameter>
-                    <Parameter id="Xf4j3BOkrEGgcFhF80-dlQ" name="Acidic phospholipids [mg/g] - RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.41">
+                    <Parameter id="dN_BcLrE50mCC9R58lKywg" name="Acidic phospholipids [mg/g] - RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.41">
                       <ValueOrigin id="21" source="Publication" description="Rodgers T, Leahy D, Rowland M. Physiologically based pharmacokinetic modeling 1: predicting the tissue distribution of moderate-to-strong bases. J Pharm Sci. 2005 Jun;94(6):1259-76. https://doi.org/10.1002/jps.20322" />
                       <Info min="0" max="1000" flag="122" seq="559" ref="0" bb="32" group="92" />
                     </Parameter>
-                    <Container id="3_a1oSiNnkisFIFOu3c1zw" name="Plasma" mode="Physical" containerType="Compartment">
+                    <Parameter id="eA1Z4OkLw0-FHcaszFTQHw" name="Vf (acidic phospholipids)-WS" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0035">
+                      <Info min="0" max="1" flag="122" seq="559" ref="0" bb="32" group="95" />
+                    </Parameter>
+                    <Container id="C-d2PMLTSE2CX0a7o185GA" name="Plasma" mode="Physical" containerType="Compartment">
                       <Tags>
                         <Tag value="Duodenum" />
                         <Tag value="Mucosa" />
                         <Tag value="SmallIntestineSegment" />
                       </Tags>
                       <Children>
-                        <Parameter id="phJMTFmJ9U6GlfHfpSDVdQ" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                        <Parameter id="jyHDoWrn90qO5PyGQnmRxQ" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
                           <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                         </Parameter>
-                        <Parameter id="1Ylavaz97EW8kLa-Mc8Q6Q" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" isDefault="1" displayUnit="l">
+                        <Parameter id="1a0tq6VSREyJmSZeowWrDA" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" isDefault="1" displayUnit="l">
                           <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                           <Info min="0" flag="62" seq="111" ref="0" bb="2" group="126" />
                         </Parameter>
-                        <Container id="j8Rz_GWUcUqUuWa0A989Qw" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                        <Container id="nRvmkUYueUuCgqIE2GONaQ" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                           <Children>
-                            <Parameter id="tQ59dbV6l0qpf3gQQgLpZQ" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                            <Parameter id="SGVtvqLp7UeQja3hR3OUyw" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                             </Parameter>
-                            <Parameter id="1vITqvTAA0iYmavmd2lZCg" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" isDefault="1">
+                            <Parameter id="894S4-KpEUaSRdRne-zClA" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                             </Parameter>
-                            <Parameter id="2im8SWhnsUamGm-yBzTGiQ" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                            <Parameter id="DQiKlMcFqEmPb2kJbJBIWA" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
                               <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                             </Parameter>
                           </Children>
                         </Container>
                       </Children>
                     </Container>
-                    <Container id="H5K_385D-UCbaUAkVzKFPA" name="BloodCells" mode="Physical" containerType="Compartment">
+                    <Container id="nwFYd1vNG0uI8cY3lrK-Zw" name="BloodCells" mode="Physical" containerType="Compartment">
                       <Tags>
                         <Tag value="Duodenum" />
                         <Tag value="Mucosa" />
                         <Tag value="SmallIntestineSegment" />
                       </Tags>
                       <Children>
-                        <Parameter id="Ri2a2yOeaE2oB-GYV0aDeA" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                        <Parameter id="UlSuUuQoLkSden3n9BGqHg" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
                           <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                         </Parameter>
-                        <Parameter id="-jF1Xy0Otk2Sm35T1KBvcw" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" isDefault="1" displayUnit="l">
+                        <Parameter id="SyT7rG6bDUa3zTVk-VPKyQ" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" isDefault="1" displayUnit="l">
                           <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                           <Info min="0" flag="62" seq="111" ref="0" bb="2" group="121" />
                         </Parameter>
-                        <Container id="N-wwculdVkGmhQ8kz6XmjQ" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                        <Container id="YNGtBTfAb0-2AzxpLc5WdA" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                           <Children>
-                            <Parameter id="xl9-6KC0skqjUJcGpA-vNg" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
-                              <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
-                            </Parameter>
-                            <Parameter id="-NmmbxbcqU2sf0cBMOC1MQ" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                            <Parameter id="7R-ift05DEah0gm95TfgPw" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                             </Parameter>
-                            <Parameter id="OOKlj_Q4Ek2KzgJnPvARYg" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" isDefault="1">
+                            <Parameter id="-yCPrlr7EkagQ9gAqcP1sA" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                             </Parameter>
+                            <Parameter id="oQYTbZxQc0aFB2zcxj2x2g" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                              <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                            </Parameter>
                           </Children>
                         </Container>
                       </Children>
                     </Container>
-                    <Container id="J3QDFPH38kedxiBgEqHhwg" name="Interstitial" mode="Physical" containerType="Compartment">
+                    <Container id="u56c8ZXo-EiW0xWduMkC5g" name="Interstitial" mode="Physical" containerType="Compartment">
                       <Tags>
                         <Tag value="Duodenum" />
                         <Tag value="Mucosa" />
                         <Tag value="SmallIntestineSegment" />
                       </Tags>
                       <Children>
-                        <Parameter id="Z22Qs2-J_0mDqRGEnBht6A" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                        <Parameter id="--0UAJQdRkCNX9I9_9ybcg" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
                           <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                         </Parameter>
-                        <Parameter id="90eYd-kQzU6nAeMup2wVAQ" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" isDefault="1" displayUnit="l">
+                        <Parameter id="4erp4NkEhUuRzOzQPKuOoQ" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" isDefault="1" displayUnit="l">
                           <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                           <Info min="0" flag="62" seq="111" ref="0" bb="2" group="124" />
                         </Parameter>
-                        <Parameter id="6ga781HVFUicf7SWxyygeQ" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_pH_INT" isDefault="1">
+                        <Parameter id="BOkwGU9IlESwwmfsV9m6hQ" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_pH_INT" isDefault="1">
                           <Tags>
                             <Tag value="Duodenum" />
                             <Tag value="Mucosa" />
@@ -7409,22 +7466,22 @@
                           </Tags>
                           <Info min="0" max="14" flag="122" seq="335" ref="0" bb="32" group="84" />
                         </Parameter>
-                        <Container id="_JMoh9cqlEKJMRzHTPHJ2w" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                        <Container id="gGVggoTaWUOwTCN_K0MvBg" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                           <Children>
-                            <Parameter id="NB95H6G3fUmPAiowpasf8g" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                            <Parameter id="sC47S75IsUmzhB-6YlGrqg" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                             </Parameter>
-                            <Parameter id="FCRoLzqfzkaz0tR4hSfM-g" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_duo" isDefault="1">
+                            <Parameter id="rZzGTno5kEmy28OGy-vHsA" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_duo" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                             </Parameter>
-                            <Parameter id="r-_O_4vJjkSR5Nzy4Lds0A" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                            <Parameter id="krCgiOjePkWaI16ntCMpkA" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
                               <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                             </Parameter>
                           </Children>
                         </Container>
                       </Children>
                     </Container>
-                    <Container id="PdhUdIESUEalieeUeCgevg" name="Intracellular" mode="Physical" containerType="Compartment">
+                    <Container id="zbImQfwyxkWPq_gPbXufRw" name="Intracellular" mode="Physical" containerType="Compartment">
                       <Tags>
                         <Tag value="Duodenum" />
                         <Tag value="IntestinalSecretionSource" />
@@ -7432,14 +7489,14 @@
                         <Tag value="SmallIntestineSegment" />
                       </Tags>
                       <Children>
-                        <Parameter id="bMGzXgSrYEKWJY_EN1v20A" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" isDefault="1" displayUnit="l">
+                        <Parameter id="aylXA1AIdU2_euDWovXVCQ" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" isDefault="1" displayUnit="l">
                           <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                         </Parameter>
-                        <Parameter id="JH28x0JbLkm_4BhkwoIIKg" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" isDefault="1" displayUnit="l">
+                        <Parameter id="JxZy-YuUyk6R2Py7CutZiA" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" isDefault="1" displayUnit="l">
                           <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                           <Info min="0" flag="62" seq="111" ref="0" bb="2" group="125" />
                         </Parameter>
-                        <Parameter id="IsClVZuyMEGMf-ca30jiGQ" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.3">
+                        <Parameter id="cp-tyMctIUyQU8GDiySi1Q" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.3">
                           <Tags>
                             <Tag value="Duodenum" />
                             <Tag value="IntestinalSecretionSource" />
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+                    <Parameter id="Ypt_53BySU-99TEaa12GbA" name="Vf (neutral lipid)-WS" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0483">
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+                    <Parameter id="-P239TUyk0-UpN10BQBy6A" name="Vf (neutral phospholipid)-RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0124">
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+                    <Parameter id="k_lQkD5SBU-H19sEOJBcSQ" name="Vf (neutral phospholipid, plasma)-WS" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0182">
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                     </Parameter>
-                    <Parameter id="mbnQpjGS8EuuFMG2KxsfSw" name="Vf (extracellular water)-RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.282">
+                    <Parameter id="roscGgi7gUyYGpZEMMcrSA" name="Vf (extracellular water)-RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.282">
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-                      <Info min="0" max="1" flag="122" seq="563" ref="0" bb="32" group="95" />
+                    <Parameter id="G2rMqgI7TESr6SQVSYxxvg" name="Vf (protein)-WS" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.15">
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+                    <Parameter id="dPxRns6L8k2b_HGTd3cqWw" name="Vf (intracellular water)-RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.456">
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                     </Parameter>
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+                    <Parameter id="wBmV83Ga_UiGJM2TzkzbrQ" name="Vf (water)-WS" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.78">
+                      <Info min="0" max="1" flag="122" seq="563" ref="0" bb="32" group="95" />
+                    </Parameter>
+                    <Parameter id="fsWirAANUUeva4lWNeVBWg" name="Acidic phospholipids [mg/g] - RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.41">
                       <ValueOrigin id="21" source="Publication" description="Rodgers T, Leahy D, Rowland M. Physiologically based pharmacokinetic modeling 1: predicting the tissue distribution of moderate-to-strong bases. J Pharm Sci. 2005 Jun;94(6):1259-76. https://doi.org/10.1002/jps.20322" />
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                     </Parameter>
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+                    <Parameter id="OoS284Vh9Ua-m-ihjpaB9w" name="Vf (acidic phospholipids)-WS" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0035">
                       <Info min="0" max="1" flag="122" seq="564" ref="0" bb="32" group="95" />
                     </Parameter>
-                    <Container id="zSjCQfE2ukibuVnEq9IN8w" name="Plasma" mode="Physical" containerType="Compartment">
+                    <Container id="4CbOfy3paECKcKT3NoWL2w" name="Plasma" mode="Physical" containerType="Compartment">
                       <Tags>
                         <Tag value="Mucosa" />
                         <Tag value="SmallIntestineSegment" />
                         <Tag value="UpperJejunum" />
                       </Tags>
                       <Children>
-                        <Parameter id="6sO-YUZr6ESy_3M7veftjw" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                        <Parameter id="qi6BW_-CYEqQ8fmXeuK-HA" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
                           <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                         </Parameter>
-                        <Parameter id="kTT9LHvvC0-JgxTKv40jrQ" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" isDefault="1" displayUnit="l">
+                        <Parameter id="NcYQDHNZdEu0hv-a2THQRA" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" isDefault="1" displayUnit="l">
                           <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                           <Info min="0" flag="62" seq="112" ref="0" bb="2" group="126" />
                         </Parameter>
-                        <Container id="_ZH8vvMJVEurmqTGtjYZ1Q" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                        <Container id="A1BHUlIIKkiKsKLswZtjHQ" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                           <Children>
-                            <Parameter id="TiCy8k9LbkSBk5BEZG7xlA" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                            <Parameter id="kqDhsZrTxEWfl2JXFbbLjw" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                             </Parameter>
-                            <Parameter id="mGA5vRwM2ka0BPa8c3vkuQ" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" isDefault="1">
+                            <Parameter id="Zoc6DWB1KkuSfEROqv18LA" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                             </Parameter>
-                            <Parameter id="lS5BcnVT_EGha2d2dPuyKg" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                            <Parameter id="99kY24xJG0-ihqn7A4xJtA" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
                               <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                             </Parameter>
                           </Children>
                         </Container>
                       </Children>
                     </Container>
-                    <Container id="r_MPzXq0uk2PEXKKnd-O8w" name="BloodCells" mode="Physical" containerType="Compartment">
+                    <Container id="2tcy-Ya4DkapvK5NMu6LXQ" name="BloodCells" mode="Physical" containerType="Compartment">
                       <Tags>
                         <Tag value="Mucosa" />
                         <Tag value="SmallIntestineSegment" />
                         <Tag value="UpperJejunum" />
                       </Tags>
                       <Children>
-                        <Parameter id="qTxbvonfuE6j1p7Wj4LG9w" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                        <Parameter id="mLVfA8wAy02Zs0aWaEL5AA" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
                           <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                         </Parameter>
-                        <Parameter id="13-TbiszRUm2va7iAzwakg" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" isDefault="1" displayUnit="l">
+                        <Parameter id="RQx2xqQrkUaXRKROdtZDoA" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" isDefault="1" displayUnit="l">
                           <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                           <Info min="0" flag="62" seq="112" ref="0" bb="2" group="121" />
                         </Parameter>
-                        <Container id="FAM9Xwq2wk-9JlzMlG7cYQ" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                        <Container id="7-kS5mtSxEmI_9jmzqWX1A" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                           <Children>
-                            <Parameter id="U5gnPQ85E0CQT1iojIsYWg" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                            <Parameter id="MQBhS7QwAkakq5HDlDxTjA" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                             </Parameter>
-                            <Parameter id="oTsK1FmOc0yE8XiWNzEL1A" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" isDefault="1">
+                            <Parameter id="vOVkfT3hY0Skeus-NcTlLQ" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                             </Parameter>
-                            <Parameter id="FuMXe8QUKEulCEXgQWzV9w" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                            <Parameter id="_cJS0nAFnUGvYMPVb7EStg" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
                               <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                             </Parameter>
                           </Children>
                         </Container>
                       </Children>
                     </Container>
-                    <Container id="E9EWxPgQP02hXkkQIXV8uw" name="Interstitial" mode="Physical" containerType="Compartment">
+                    <Container id="LWvKqL4dm0yxsghkJ8nxdw" name="Interstitial" mode="Physical" containerType="Compartment">
                       <Tags>
                         <Tag value="Mucosa" />
                         <Tag value="SmallIntestineSegment" />
                         <Tag value="UpperJejunum" />
                       </Tags>
                       <Children>
-                        <Parameter id="pQS_EWLKb020IvtFgAHECw" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                        <Parameter id="zujJP-swmEOuAFwvp4hTrQ" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
                           <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                         </Parameter>
-                        <Parameter id="g4-BWsbvEEqHrZwuj9j9eQ" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" isDefault="1" displayUnit="l">
+                        <Parameter id="CXyweogYIUKV2bDjAGjH1w" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" isDefault="1" displayUnit="l">
                           <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                           <Info min="0" flag="62" seq="112" ref="0" bb="2" group="124" />
                         </Parameter>
-                        <Parameter id="iYZY-8zY3keNB6lY5zzkqw" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_pH_INT" isDefault="1">
+                        <Parameter id="RC7lqb8K-EaoZXuxpoXB1g" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_pH_INT" isDefault="1">
                           <Tags>
                             <Tag value="Mucosa" />
                             <Tag value="SmallIntestineSegment" />
@@ -7676,22 +7733,22 @@
                           </Tags>
                           <Info min="0" max="14" flag="122" seq="338" ref="0" bb="32" group="84" />
                         </Parameter>
-                        <Container id="HAW6ozpgxke4ZXT-HVcawA" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                        <Container id="0V2ItGhcskufi6uOloIYUg" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                           <Children>
-                            <Parameter id="HKzPuBtsVE-XZ6WcWw1ygQ" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                            <Parameter id="faN07QYMIkWo2cFfohm8VQ" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                             </Parameter>
-                            <Parameter id="6hg67kQXQ02Kr82vyA9Zsg" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_uje" isDefault="1">
+                            <Parameter id="vWIqwM7EWkeepr7WmljXxA" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_uje" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                             </Parameter>
-                            <Parameter id="fvuVFTjqvUGlPGkxOdiw8Q" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                            <Parameter id="hyhJixo8S0WHzFbIO1wD0w" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
                               <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                             </Parameter>
                           </Children>
                         </Container>
                       </Children>
                     </Container>
-                    <Container id="CcO7OCe_ME-7FudeoxVNtA" name="Intracellular" mode="Physical" containerType="Compartment">
+                    <Container id="sydFGAeVT0OsnWNbGigz6A" name="Intracellular" mode="Physical" containerType="Compartment">
                       <Tags>
                         <Tag value="IntestinalSecretionSource" />
                         <Tag value="Mucosa" />
@@ -7699,14 +7756,14 @@
                         <Tag value="UpperJejunum" />
                       </Tags>
                       <Children>
-                        <Parameter id="7FIjfoOJ00OW45JYQmpdpQ" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" isDefault="1" displayUnit="l">
+                        <Parameter id="A5_3TzSAIEKfHdlLbfp6Mw" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" isDefault="1" displayUnit="l">
                           <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                         </Parameter>
-                        <Parameter id="k_DE7cZkuEmp4dIJLiVkHA" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" isDefault="1" displayUnit="l">
+                        <Parameter id="QIw3f1zMSk2L1NXSb_FK6w" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" isDefault="1" displayUnit="l">
                           <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                           <Info min="0" flag="62" seq="112" ref="0" bb="2" group="125" />
                         </Parameter>
-                        <Parameter id="DPW-YcW0n0SGikCif27_lg" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.3">
+                        <Parameter id="3o3TzIxg-UiHgkaqiCoeEg" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.3">
                           <Tags>
                             <Tag value="IntestinalSecretionSource" />
                             <Tag value="Mucosa" />
@@ -7716,226 +7773,226 @@
                           <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
                           <Info min="0" max="14" flag="122" seq="338" ref="0" bb="32" group="83" />
                         </Parameter>
-                        <Container id="QkfYbA0P7EeCS1wlhCDNmw" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                        <Container id="JGO3LqUG70eJGojkp1ryIQ" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                           <Children>
-                            <Parameter id="mYVHNUvJsUiWTu1DW_9RKw" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                            <Parameter id="3PC9vPPOF0aq6zP0YRBH_w" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
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+                    <Parameter id="Z5nAkyCQNEaVRSRpXV69XQ" name="Vf (neutral phospholipid)-RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0124">
                       <ValueOrigin id="22" source="Publication" description="Rodgers T, Rowland M. Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J Pharm Sci. 2006 Jun;95(6):1238-57 https://doi.org/10.1002/jps.20502" />
                       <Info min="0" max="1" flag="122" seq="566" ref="0" bb="32" group="92" />
                     </Parameter>
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-                      <Info min="0" max="1" flag="122" seq="567" ref="0" bb="32" group="95" />
+                    <Parameter id="a67iI6hXeEyAavQ94VlIjw" name="Vf (neutral phospholipid, plasma)-WS" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0182">
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                     </Parameter>
-                    <Parameter id="1Aq154aRI0WnRj86NpgopQ" name="Vf (extracellular water)-RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.282">
+                    <Parameter id="4TgPXm-HHEiZ2JmnSiC3yA" name="Vf (extracellular water)-RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.282">
                       <ValueOrigin id="21" source="Publication" description="Rodgers T, Leahy D, Rowland M. Physiologically based pharmacokinetic modeling 1: predicting the tissue distribution of moderate-to-strong bases. J Pharm Sci. 2005 Jun;94(6):1259-76. https://doi.org/10.1002/jps.20322" />
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+                    <Parameter id="2vbTuw09aEepKLCN70L92g" name="Vf (protein)-WS" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.15">
+                      <Info min="0" max="1" flag="122" seq="567" ref="0" bb="32" group="95" />
+                    </Parameter>
+                    <Parameter id="ZfcsoBqPvUeLuBmB6q8LGA" name="Vf (intracellular water)-RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.456">
                       <ValueOrigin id="22" source="Publication" description="Rodgers T, Rowland M. Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J Pharm Sci. 2006 Jun;95(6):1238-57 https://doi.org/10.1002/jps.20502" />
                       <Info min="0" max="1" flag="122" seq="568" ref="0" bb="32" group="92" />
                     </Parameter>
-                    <Parameter id="JiYSc3llc0WzoAADhwfabw" name="Vf (water)-WS" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.78">
+                    <Parameter id="UHAlhdZCmU2OAmMW_aj4LA" name="Vf (water)-WS" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.78">
                       <Info min="0" max="1" flag="122" seq="568" ref="0" bb="32" group="95" />
                     </Parameter>
-                    <Parameter id="IzTrA6ZPGEmT2y3dkQ03sA" name="Acidic phospholipids [mg/g] - RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.41">
+                    <Parameter id="2kSe7dIRTESKpEOEznRL8w" name="Acidic phospholipids [mg/g] - RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.41">
                       <ValueOrigin id="21" source="Publication" description="Rodgers T, Leahy D, Rowland M. Physiologically based pharmacokinetic modeling 1: predicting the tissue distribution of moderate-to-strong bases. J Pharm Sci. 2005 Jun;94(6):1259-76. https://doi.org/10.1002/jps.20322" />
                       <Info min="0" max="1000" flag="122" seq="569" ref="0" bb="32" group="92" />
                     </Parameter>
-                    <Parameter id="G6q-05Pbpk-xUSPd2rpd3w" name="Vf (acidic phospholipids)-WS" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0035">
+                    <Parameter id="R2mWDyc84k-nQOFn7TvVSQ" name="Vf (acidic phospholipids)-WS" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0035">
                       <Info min="0" max="1" flag="122" seq="569" ref="0" bb="32" group="95" />
                     </Parameter>
-                    <Container id="zrKtW28pvEStr3uQ0NWXgQ" name="Plasma" mode="Physical" containerType="Compartment">
+                    <Container id="_vxo4wcBG0Spf1REJOKECA" name="Plasma" mode="Physical" containerType="Compartment">
                       <Tags>
                         <Tag value="LowerJejunum" />
                         <Tag value="Mucosa" />
                         <Tag value="SmallIntestineSegment" />
                       </Tags>
                       <Children>
-                        <Parameter id="Caw5zLvyNEOmoTBI93fYwg" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                        <Parameter id="nF8bDOY1_Eyq9tEc0VyvIQ" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
                           <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                         </Parameter>
-                        <Parameter id="OaP9KwKIEkK5rKFnAQG8Bg" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" isDefault="1" displayUnit="l">
+                        <Parameter id="utiEsKMUaUWsXnEi0RISpg" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" isDefault="1" displayUnit="l">
                           <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                           <Info min="0" flag="62" seq="113" ref="0" bb="2" group="126" />
                         </Parameter>
-                        <Container id="0Xc6EBNsl0mRgPqBdLWMJA" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                        <Container id="0riDL5Qo6UO8HXgD5jkz7A" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                           <Children>
-                            <Parameter id="BgGqC_1AC02IyMXPnT2LbQ" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                            <Parameter id="voBs4ikKlUGKOyEMh8f0Xw" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                             </Parameter>
-                            <Parameter id="l_BbsfkZsEefgiz4wDIUJQ" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" isDefault="1">
+                            <Parameter id="b8Eww1xuXkqy_5pik3w0Dw" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                             </Parameter>
-                            <Parameter id="4s4_VMUs4E-VXbnofaJFTg" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                            <Parameter id="p2KczbBu0kextv8mcrT8uA" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
                               <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                             </Parameter>
                           </Children>
                         </Container>
                       </Children>
                     </Container>
-                    <Container id="Wda4ndmPT0GokpTDOLelAw" name="BloodCells" mode="Physical" containerType="Compartment">
+                    <Container id="K659GHjLpkKqC6Y--ONvog" name="BloodCells" mode="Physical" containerType="Compartment">
                       <Tags>
                         <Tag value="LowerJejunum" />
                         <Tag value="Mucosa" />
                         <Tag value="SmallIntestineSegment" />
                       </Tags>
                       <Children>
-                        <Parameter id="27MstyzftUmtXSEFp6Z_mA" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                        <Parameter id="nnH_CAmiMUitPveLMMdZyg" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
                           <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                         </Parameter>
-                        <Parameter id="i6f3hI-rskOo9C1N20xG1w" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" isDefault="1" displayUnit="l">
+                        <Parameter id="6fkmoitjREGuQpkf_tEMNg" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" isDefault="1" displayUnit="l">
                           <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                           <Info min="0" flag="62" seq="113" ref="0" bb="2" group="121" />
                         </Parameter>
-                        <Container id="IxD6Gnkfik6URyq58F3xwA" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                        <Container id="61ZDV0l6fEmym4UnZytJ5g" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                           <Children>
-                            <Parameter id="aFnnhtMzVkCR9thNGlnGRw" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                            <Parameter id="3vETXBaaEUqPOlrBhqveMg" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                             </Parameter>
-                            <Parameter id="IUrSJieZ9UOA9p7FvvJDXA" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" isDefault="1">
+                            <Parameter id="SVTVBrAEHEyyJFnRBzcFIA" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                             </Parameter>
-                            <Parameter id="03VxR2eXvkuMHeF53acrQQ" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                            <Parameter id="_3XJfmM6tU68s8U_i9Vn9g" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
                               <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                             </Parameter>
                           </Children>
                         </Container>
                       </Children>
                     </Container>
-                    <Container id="5nN5NiM1M0K5ZU2nRPNl_Q" name="Interstitial" mode="Physical" containerType="Compartment">
+                    <Container id="UQ_qU6QMZUaTyT5su0zOcw" name="Interstitial" mode="Physical" containerType="Compartment">
                       <Tags>
                         <Tag value="LowerJejunum" />
                         <Tag value="Mucosa" />
                         <Tag value="SmallIntestineSegment" />
                       </Tags>
                       <Children>
-                        <Parameter id="vxH60F8hZ06LpxYLT6K8jQ" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                        <Parameter id="CY7rOqA7Q0mtcae4PLeIqg" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
                           <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                         </Parameter>
-                        <Parameter id="v8tazHEbnkKSAMjRzcQvVw" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" isDefault="1" displayUnit="l">
+                        <Parameter id="WLR2EldS5UWHHMfSKlLcJA" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" isDefault="1" displayUnit="l">
                           <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                           <Info min="0" flag="62" seq="113" ref="0" bb="2" group="124" />
                         </Parameter>
-                        <Parameter id="pWZs-qvK6UatMyX4OeU9KA" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_pH_INT" isDefault="1">
+                        <Parameter id="PgRi8eu1IkeYtE63JMyL-A" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_pH_INT" isDefault="1">
                           <Tags>
                             <Tag value="LowerJejunum" />
                             <Tag value="Mucosa" />
@@ -7943,22 +8000,22 @@
                           </Tags>
                           <Info min="0" max="14" flag="122" seq="341" ref="0" bb="32" group="84" />
                         </Parameter>
-                        <Container id="dm3arTDYg06mE_jJgIevnQ" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                        <Container id="AwKi9Rt-QkmqhBYVo-cl-g" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                           <Children>
-                            <Parameter id="VehPO1xejEWyEbPPmzbl5Q" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                            <Parameter id="UUFHKGF9rUCggZF46y68mA" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                             </Parameter>
-                            <Parameter id="W24T2Trl10W45vS6tq2aDQ" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_lje" isDefault="1">
+                            <Parameter id="P-1B5rzJo0yXAOe5hi_QeA" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_lje" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                             </Parameter>
-                            <Parameter id="6kQ8_zEui0GA-y-Uh7uxoA" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                            <Parameter id="kVMqpFkJR0CXJbbJ61pVFw" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
                               <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                             </Parameter>
                           </Children>
                         </Container>
                       </Children>
                     </Container>
-                    <Container id="7dlPgIDV3kmO0AMYM-CWrQ" name="Intracellular" mode="Physical" containerType="Compartment">
+                    <Container id="ZVzsDd2s6USCvF5KFRacyQ" name="Intracellular" mode="Physical" containerType="Compartment">
                       <Tags>
                         <Tag value="IntestinalSecretionSource" />
                         <Tag value="LowerJejunum" />
@@ -7966,14 +8023,14 @@
                         <Tag value="SmallIntestineSegment" />
                       </Tags>
                       <Children>
-                        <Parameter id="ajw3CIvfGkytNsixOrVHbw" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" isDefault="1" displayUnit="l">
+                        <Parameter id="IB_UgFYKFUmV9ZLzbqS8Ag" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" isDefault="1" displayUnit="l">
                           <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                         </Parameter>
-                        <Parameter id="ong7FgNj1kG4O0NPQtIQ4w" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" isDefault="1" displayUnit="l">
+                        <Parameter id="eTsMTbYSv0CyY8CJlu5AAA" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" isDefault="1" displayUnit="l">
                           <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                           <Info min="0" flag="62" seq="113" ref="0" bb="2" group="125" />
                         </Parameter>
-                        <Parameter id="ZS6ZCkorFUOflFRFDvC6vA" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.3">
+                        <Parameter id="noTiVzNaYU6u3gD_oXqkog" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.3">
                           <Tags>
                             <Tag value="IntestinalSecretionSource" />
                             <Tag value="LowerJejunum" />
@@ -7983,226 +8040,226 @@
                           <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
                           <Info min="0" max="14" flag="122" seq="341" ref="0" bb="32" group="83" />
                         </Parameter>
-                        <Container id="t3iC34-WN0eeWh8GyjIoCQ" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                        <Container id="KDuNJy2sJUqovZBqvPuJBw" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                           <Children>
-                            <Parameter id="8uPgqM3BSkGrt2WYT0IAMQ" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                            <Parameter id="RPe36IEFpESrmUt3sCuaWw" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                             </Parameter>
-                            <Parameter id="GDodrQXGn0y2aVBx90oKJQ" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_lje" isDefault="1">
+                            <Parameter id="oD3ex4r8AUenvlmw7_A3CQ" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_lje" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                             </Parameter>
-                            <Parameter id="uu434HQoOk6dOqTVnF_CdQ" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                            <Parameter id="jbVq8XnJHkiYfCAFaLKdzQ" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
                               <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                             </Parameter>
                           </Children>
                         </Container>
                       </Children>
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                       <ValueOrigin id="21" source="Publication" description="Rodgers T, Leahy D, Rowland M. Physiologically based pharmacokinetic modeling 1: predicting the tissue distribution of moderate-to-strong bases. J Pharm Sci. 2005 Jun;94(6):1259-76. https://doi.org/10.1002/jps.20322" />
                       <Info min="0" max="1" flag="122" seq="572" ref="0" bb="32" group="92" />
                     </Parameter>
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+                    <Parameter id="OQczWDGHt0KnQbeJ7v6jEA" name="Vf (protein)-WS" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.15">
                       <Info min="0" max="1" flag="122" seq="572" ref="0" bb="32" group="95" />
                     </Parameter>
-                    <Parameter id="gss3fbfiHkeKzWzXwpdbXg" name="Vf (intracellular water)-RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.456">
+                    <Parameter id="fA0GXR2Uv02fUE7b5eg5qA" name="Vf (intracellular water)-RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.456">
                       <ValueOrigin id="22" source="Publication" description="Rodgers T, Rowland M. Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J Pharm Sci. 2006 Jun;95(6):1238-57 https://doi.org/10.1002/jps.20502" />
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                     </Parameter>
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+                    <Parameter id="kCq5x3EIxk2zWUer-d8R4w" name="Vf (water)-WS" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.78">
                       <Info min="0" max="1" flag="122" seq="573" ref="0" bb="32" group="95" />
                     </Parameter>
-                    <Parameter id="OfXvjw5oTUy4eFNy9IoqsQ" name="Vf (acidic phospholipids)-WS" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0035">
-                      <Info min="0" max="1" flag="122" seq="574" ref="0" bb="32" group="95" />
-                    </Parameter>
-                    <Parameter id="7N_Zekb9PE-Fpm1MCbYUMw" name="Acidic phospholipids [mg/g] - RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.41">
+                    <Parameter id="Jy3hiGcJI06xoxmoKKFh9g" name="Acidic phospholipids [mg/g] - RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.41">
                       <ValueOrigin id="21" source="Publication" description="Rodgers T, Leahy D, Rowland M. Physiologically based pharmacokinetic modeling 1: predicting the tissue distribution of moderate-to-strong bases. J Pharm Sci. 2005 Jun;94(6):1259-76. https://doi.org/10.1002/jps.20322" />
                       <Info min="0" max="1000" flag="122" seq="574" ref="0" bb="32" group="92" />
                     </Parameter>
-                    <Container id="8Ac8jM2ASUOjvqHKHA7z0Q" name="Plasma" mode="Physical" containerType="Compartment">
+                    <Parameter id="CnuNE0gggU-OFbuyrTovtw" name="Vf (acidic phospholipids)-WS" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0035">
+                      <Info min="0" max="1" flag="122" seq="574" ref="0" bb="32" group="95" />
+                    </Parameter>
+                    <Container id="ZzglrFxN2USNK0EBKHAKHw" name="Plasma" mode="Physical" containerType="Compartment">
                       <Tags>
                         <Tag value="Mucosa" />
                         <Tag value="SmallIntestineSegment" />
                         <Tag value="UpperIleum" />
                       </Tags>
                       <Children>
-                        <Parameter id="0VymyEENKU24mDnjQwj56A" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                        <Parameter id="YouBnORwakuG9VocWgpYcQ" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
                           <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                         </Parameter>
-                        <Parameter id="xEGkJvy9nkSJsVRjJMzvyA" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" isDefault="1" displayUnit="l">
+                        <Parameter id="m05Ub0LnukGavULVIzkU4w" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" isDefault="1" displayUnit="l">
                           <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                           <Info min="0" flag="62" seq="114" ref="0" bb="2" group="126" />
                         </Parameter>
-                        <Container id="oD7yUnH6t0qteY4LcWcwpQ" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                        <Container id="7_bxUQN6iEyx4vW4BI0NCw" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                           <Children>
-                            <Parameter id="9xAGxAsjJECkFqQfsqZjMw" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                            <Parameter id="Yq8Ubj2w40WkiUGLoO-HVA" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                             </Parameter>
-                            <Parameter id="4Nsr7OO-mUah8tr98eoAxA" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" isDefault="1">
+                            <Parameter id="QeN4AMa6okOBM_KmP6kZjQ" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                             </Parameter>
-                            <Parameter id="KQZN17MWYU6GzjMELqQEfg" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                            <Parameter id="6oOGB2Gg4k2uwPsK2tDvOg" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
                               <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                             </Parameter>
                           </Children>
                         </Container>
                       </Children>
                     </Container>
-                    <Container id="WMcsnhxGN0-dMioJaAzdBw" name="BloodCells" mode="Physical" containerType="Compartment">
+                    <Container id="A-W-9HQaxU2NdeD01TJ9vw" name="BloodCells" mode="Physical" containerType="Compartment">
                       <Tags>
                         <Tag value="Mucosa" />
                         <Tag value="SmallIntestineSegment" />
                         <Tag value="UpperIleum" />
                       </Tags>
                       <Children>
-                        <Parameter id="fOEVArqPk0eIzCrmtubuPw" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                        <Parameter id="AhXwh4_YMEOj-7NRoPDlrw" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
                           <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                         </Parameter>
-                        <Parameter id="6HSoTYL8OUSH9yiYQgdbQQ" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" isDefault="1" displayUnit="l">
+                        <Parameter id="KFfpXn7rO02O9z3WotrnWQ" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" isDefault="1" displayUnit="l">
                           <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                           <Info min="0" flag="62" seq="114" ref="0" bb="2" group="121" />
                         </Parameter>
-                        <Container id="-nzHgomQ20q2Ba1vnpCCvg" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                        <Container id="9E3BkXaWg0WYbaQQZmYmLQ" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                           <Children>
-                            <Parameter id="inGapzjIPUG8-T5ujh-ozw" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                            <Parameter id="VNGlfAFEC0OWz05cbNulkQ" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                             </Parameter>
-                            <Parameter id="TqiND05xCkSPFN7eStA_Lw" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" isDefault="1">
+                            <Parameter id="ohK071wemUeN7nKf9SdDzg" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                             </Parameter>
-                            <Parameter id="cz2DuRIYWUK3B1MvaVMFEg" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                            <Parameter id="OcFUgpmOrUu0VLanrRxjSA" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
                               <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                             </Parameter>
                           </Children>
                         </Container>
                       </Children>
                     </Container>
-                    <Container id="nq1wRgZMikC94IeNXWIr0A" name="Interstitial" mode="Physical" containerType="Compartment">
+                    <Container id="3bFJZwHpsEmLwakaWGA6bA" name="Interstitial" mode="Physical" containerType="Compartment">
                       <Tags>
                         <Tag value="Mucosa" />
                         <Tag value="SmallIntestineSegment" />
                         <Tag value="UpperIleum" />
                       </Tags>
                       <Children>
-                        <Parameter id="IcqhQb2Xdke8esyW9rx51g" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                        <Parameter id="N0ZuPPvku0yJ5yeHKCaykw" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
                           <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                         </Parameter>
-                        <Parameter id="_JTKVeofI0meb_cJWjqL-w" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" isDefault="1" displayUnit="l">
+                        <Parameter id="wmYApBSx9E6b1Ax966VLTQ" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" isDefault="1" displayUnit="l">
                           <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                           <Info min="0" flag="62" seq="114" ref="0" bb="2" group="124" />
                         </Parameter>
-                        <Parameter id="RaIgA0KYdUCK3PKRHCxTtQ" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_pH_INT" isDefault="1">
+                        <Parameter id="-jULydGuyE-trZzsmo23ug" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_pH_INT" isDefault="1">
                           <Tags>
                             <Tag value="Mucosa" />
                             <Tag value="SmallIntestineSegment" />
@@ -8210,22 +8267,22 @@
                           </Tags>
                           <Info min="0" max="14" flag="122" seq="344" ref="0" bb="32" group="84" />
                         </Parameter>
-                        <Container id="oidjJ6mxhUuFmGBptms_WQ" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                        <Container id="Nm7aUG77jE25hAAIEd88pg" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                           <Children>
-                            <Parameter id="6y_wXu7kTUGX3tW4WQw9rg" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                            <Parameter id="gGWG9P8pwUG-Uvd2cJGnAQ" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                             </Parameter>
-                            <Parameter id="7MQ8ySX_N0Cr9Mbxp0LVGA" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_uil" isDefault="1">
+                            <Parameter id="hM-NPDhs8UuGgaUg6nUx5g" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_uil" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                             </Parameter>
-                            <Parameter id="Tg_7_hIq-0eM29EWNT2Pyw" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                            <Parameter id="EgUfOOi0zU6obuFCz-y8Zw" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
                               <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                             </Parameter>
                           </Children>
                         </Container>
                       </Children>
                     </Container>
-                    <Container id="nQCFgAfCi0WyyeCINOyruw" name="Intracellular" mode="Physical" containerType="Compartment">
+                    <Container id="shLM7VZLMEWIWyy3ZU-Wlw" name="Intracellular" mode="Physical" containerType="Compartment">
                       <Tags>
                         <Tag value="IntestinalSecretionSource" />
                         <Tag value="Mucosa" />
@@ -8233,14 +8290,14 @@
                         <Tag value="UpperIleum" />
                       </Tags>
                       <Children>
-                        <Parameter id="cuELQV6eGE-FI77W9cm3-Q" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" isDefault="1" displayUnit="l">
+                        <Parameter id="flQLimvWWEexODizA5MlKQ" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" isDefault="1" displayUnit="l">
                           <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                         </Parameter>
-                        <Parameter id="GO2btIKlWEGWv1SyDOZGew" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" isDefault="1" displayUnit="l">
+                        <Parameter id="V7WcSKN1sUWy-GybaOMyEA" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" isDefault="1" displayUnit="l">
                           <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                           <Info min="0" flag="62" seq="114" ref="0" bb="2" group="125" />
                         </Parameter>
-                        <Parameter id="Us9FNWdpfE-DhfoxaLHigg" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.3">
+                        <Parameter id="rcOzxPD_60WxoDibwCLr5w" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.3">
                           <Tags>
                             <Tag value="IntestinalSecretionSource" />
                             <Tag value="Mucosa" />
@@ -8250,226 +8307,226 @@
                           <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
                           <Info min="0" max="14" flag="122" seq="344" ref="0" bb="32" group="83" />
                         </Parameter>
-                        <Container id="9zmq6ipK702tI3Yh8TiVHA" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                        <Container id="2dqp5gAZnUm67caZZpihPQ" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                           <Children>
-                            <Parameter id="6uWvHLOyrU2xQGm8EIGUSA" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_uil" isDefault="1">
-                              <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
-                            </Parameter>
-                            <Parameter id="2VorN8IeGUGvuUgE6RO3PA" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                            <Parameter id="r-IZLgCls0aLaNVa4t3aHg" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                             </Parameter>
-                            <Parameter id="PGmLpzs25EaixgQLPjU6qg" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                            <Parameter id="F9SXg0nZek-1-cddfubQPw" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_uil" isDefault="1">
+                              <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                            </Parameter>
+                            <Parameter id="bdGE8nePwkywWLLajh0uRQ" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
                               <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                             </Parameter>
                           </Children>
                         </Container>
                       </Children>
                     </Container>
-                    <Container id="gkARh_so2kGwzsrpkl4yyA" name="MoleculeProperties" mode="Logical" containerType="Molecule" />
+                    <Container id="57aSrCdksEusfots49fpLQ" name="MoleculeProperties" mode="Logical" containerType="Molecule" />
                   </Children>
                 </Container>
-                <Container id="I8qkBXWCGEeSZ1KR1AZYSg" name="LowerIleum" mode="Logical" containerType="Compartment">
+                <Container id="yIdcoNApM0yMxnBE-TSzDw" name="LowerIleum" mode="Logical" containerType="Compartment">
                   <Children>
-                    <Parameter id="zoNREmbCQ0mYpgy6Qofylg" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
+                    <Parameter id="jX-DIi0xeEeaZZl8VujVrg" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
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-                    <Parameter id="gEG6x3Uh70G8011xVi0iAg" name="Vf (intracellular water)-RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.456">
+                    <Parameter id="FUjVGSPMEUGAIqJL2rkkzw" name="Vf (intracellular water)-RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.456">
                       <ValueOrigin id="22" source="Publication" description="Rodgers T, Rowland M. Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J Pharm Sci. 2006 Jun;95(6):1238-57 https://doi.org/10.1002/jps.20502" />
                       <Info min="0" max="1" flag="122" seq="578" ref="0" bb="32" group="92" />
                     </Parameter>
-                    <Parameter id="7QSVxqEza0Wnnmhrwkz83g" name="Vf (water)-WS" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.78">
+                    <Parameter id="1AOMePnZr021avtD5k1v1w" name="Vf (water)-WS" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.78">
                       <Info min="0" max="1" flag="122" seq="578" ref="0" bb="32" group="95" />
                     </Parameter>
-                    <Parameter id="baLAyfzGlUaB9lQG5sLxgQ" name="Acidic phospholipids [mg/g] - RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.41">
+                    <Parameter id="VCJ7VZ7Cg0mg-7d27gy31Q" name="Acidic phospholipids [mg/g] - RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.41">
                       <ValueOrigin id="21" source="Publication" description="Rodgers T, Leahy D, Rowland M. Physiologically based pharmacokinetic modeling 1: predicting the tissue distribution of moderate-to-strong bases. J Pharm Sci. 2005 Jun;94(6):1259-76. https://doi.org/10.1002/jps.20322" />
                       <Info min="0" max="1000" flag="122" seq="579" ref="0" bb="32" group="92" />
                     </Parameter>
-                    <Parameter id="zeIColo2ika3z-Q9h6C82g" name="Vf (acidic phospholipids)-WS" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0035">
+                    <Parameter id="i4UzJeeXBkuK-fIbR9KOgg" name="Vf (acidic phospholipids)-WS" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0035">
                       <Info min="0" max="1" flag="122" seq="579" ref="0" bb="32" group="95" />
                     </Parameter>
-                    <Container id="E7GcOFYu-UOF39Lu9dz1iw" name="Plasma" mode="Physical" containerType="Compartment">
+                    <Container id="zc7BjQ5jIkCNKX-V89xf8w" name="Plasma" mode="Physical" containerType="Compartment">
                       <Tags>
                         <Tag value="LowerIleum" />
                         <Tag value="Mucosa" />
                         <Tag value="SmallIntestineSegment" />
                       </Tags>
                       <Children>
-                        <Parameter id="E351bPgjzUKuILykNugrUA" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                        <Parameter id="-9R7WVe1I0OoeNPLINKGsw" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
                           <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                         </Parameter>
-                        <Parameter id="9vlrqjAXaUm5EtzkZSX_Lg" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" isDefault="1" displayUnit="l">
+                        <Parameter id="00s83fqf30mSuea1Qrozkg" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" isDefault="1" displayUnit="l">
                           <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                           <Info min="0" flag="62" seq="115" ref="0" bb="2" group="126" />
                         </Parameter>
-                        <Container id="qvgx_cSyBUW2MHexKJjVjw" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                        <Container id="GJn463hwlUaqkT4M4yw5IQ" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                           <Children>
-                            <Parameter id="bZs5z9_UnEOTxZxidDDxTg" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
-                              <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                            <Parameter id="hOD3i-6cdUCI2M6URh9GnQ" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                              <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                             </Parameter>
-                            <Parameter id="S131m9p-EEiNTCdGamE8UA" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" isDefault="1">
+                            <Parameter id="nEvgYOZbikexAVXpMMbgBg" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                             </Parameter>
-                            <Parameter id="o_aiD1DXNEGGdj0OvIMvPw" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
-                              <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                            <Parameter id="tlMZ7KVoeU2CsTUQz7263Q" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                              <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                             </Parameter>
                           </Children>
                         </Container>
                       </Children>
                     </Container>
-                    <Container id="f9sONmhHJ065miNP8o2zyw" name="BloodCells" mode="Physical" containerType="Compartment">
+                    <Container id="f_JTFfr9tEWHRt0TeebnGw" name="BloodCells" mode="Physical" containerType="Compartment">
                       <Tags>
                         <Tag value="LowerIleum" />
                         <Tag value="Mucosa" />
                         <Tag value="SmallIntestineSegment" />
                       </Tags>
                       <Children>
-                        <Parameter id="e4pnxbNJMk-YFftxgyVWIA" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                        <Parameter id="o0KrSTPFJ0O9xaE1moGs2Q" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
                           <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                         </Parameter>
-                        <Parameter id="nHLU8H9Fo0edftc8uBFbuQ" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" isDefault="1" displayUnit="l">
+                        <Parameter id="uJnvF9fWPUOVt8GvYTYrpQ" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" isDefault="1" displayUnit="l">
                           <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                           <Info min="0" flag="62" seq="115" ref="0" bb="2" group="121" />
                         </Parameter>
-                        <Container id="lKRajLiBPEOq_hbEECfZUQ" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                        <Container id="xmrD2OYZpE2CDdB11CsrFA" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                           <Children>
-                            <Parameter id="FcqrkZ_cnkep3uuSMV-2uQ" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                            <Parameter id="4_nVNu4MAUuovxb9jk1EHg" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                             </Parameter>
-                            <Parameter id="HPqHkOkF4kGyO7RfFGbnqQ" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" isDefault="1">
+                            <Parameter id="L_bazrFMPkGuqqgUBjtsMQ" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                             </Parameter>
-                            <Parameter id="wW6GhJ3HuUKvMNlGGCp17A" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                            <Parameter id="nbgsTes5sUSOEixu-dgeoQ" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
                               <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                             </Parameter>
                           </Children>
                         </Container>
                       </Children>
                     </Container>
-                    <Container id="wLhuhUiVaU6hMjW9YCcQkg" name="Interstitial" mode="Physical" containerType="Compartment">
+                    <Container id="4oq7UP86KUyjpoaRtRwk_A" name="Interstitial" mode="Physical" containerType="Compartment">
                       <Tags>
                         <Tag value="LowerIleum" />
                         <Tag value="Mucosa" />
                         <Tag value="SmallIntestineSegment" />
                       </Tags>
                       <Children>
-                        <Parameter id="IcLAMcoP80ulBZ6aY2ugqA" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                        <Parameter id="D5arz8L_ekKqdaJccIKDhw" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
                           <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                         </Parameter>
-                        <Parameter id="5_8Q2GLxVkaV8OdmRVSKRg" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" isDefault="1" displayUnit="l">
+                        <Parameter id="kAMV_58wFEKcjzsEygOBYQ" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" isDefault="1" displayUnit="l">
                           <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                           <Info min="0" flag="62" seq="115" ref="0" bb="2" group="124" />
                         </Parameter>
-                        <Parameter id="wt4bGuByGk2CDMzRg-UArA" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_pH_INT" isDefault="1">
+                        <Parameter id="rGiJCiqhXEiSb40MLkw_tg" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_pH_INT" isDefault="1">
                           <Tags>
                             <Tag value="LowerIleum" />
                             <Tag value="Mucosa" />
@@ -8477,22 +8534,22 @@
                           </Tags>
                           <Info min="0" max="14" flag="122" seq="347" ref="0" bb="32" group="84" />
                         </Parameter>
-                        <Container id="jnnkGvEJU0S8V6F9CBDhWQ" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                        <Container id="kOVj7qpb102p8YgkZ-dh8A" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                           <Children>
-                            <Parameter id="qlbFAkzjeUWxkOPrMwn4ew" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                            <Parameter id="8GIgx51XLUCrAqDZc1srGg" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                             </Parameter>
-                            <Parameter id="P0rsJyNoq0erREjFj6SUMA" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_lil" isDefault="1">
+                            <Parameter id="1ScaLdm3DkSX9xgpORuVHA" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_lil" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                             </Parameter>
-                            <Parameter id="W54l6V447EuluLooe2RuXg" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                            <Parameter id="NeaAipra9EimalF9Tya5lA" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
                               <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                             </Parameter>
                           </Children>
                         </Container>
                       </Children>
                     </Container>
-                    <Container id="4DN3tqIxrEi2lucD2dTPCg" name="Intracellular" mode="Physical" containerType="Compartment">
+                    <Container id="jIkP3QhTpkaaJF858jl37g" name="Intracellular" mode="Physical" containerType="Compartment">
                       <Tags>
                         <Tag value="IntestinalSecretionSource" />
                         <Tag value="LowerIleum" />
@@ -8500,14 +8557,14 @@
                         <Tag value="SmallIntestineSegment" />
                       </Tags>
                       <Children>
-                        <Parameter id="OuDO1Il7b0WCteVQ8jruvw" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" isDefault="1" displayUnit="l">
+                        <Parameter id="M5DwDOWUxUKyYU-i2H1SHA" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" isDefault="1" displayUnit="l">
                           <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                         </Parameter>
-                        <Parameter id="SglN1UC1kU2dvPtsCAVzpw" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" isDefault="1" displayUnit="l">
+                        <Parameter id="eSWiP7C92ECTey1RR-TL0w" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" isDefault="1" displayUnit="l">
                           <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                           <Info min="0" flag="62" seq="115" ref="0" bb="2" group="125" />
                         </Parameter>
-                        <Parameter id="s7DdNq75CkePWxEZKnCslA" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.3">
+                        <Parameter id="vT1vnQ2QMUSU91ocbsbt-A" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.3">
                           <Tags>
                             <Tag value="IntestinalSecretionSource" />
                             <Tag value="LowerIleum" />
@@ -8517,71 +8574,72 @@
                           <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
                           <Info min="0" max="14" flag="122" seq="347" ref="0" bb="32" group="83" />
                         </Parameter>
-                        <Container id="Yto8VXTbjUKmM18v1JpyJw" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                        <Container id="coyF9m8vs0GdIBpHwzfVgQ" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                           <Children>
-                            <Parameter id="gNiH7_HErEe97KJRnkCnOA" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                            <Parameter id="52H2WlttakmXl-EJURIoag" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                             </Parameter>
-                            <Parameter id="lLlOMsupSkieD6VNG0J7zQ" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_lil" isDefault="1">
+                            <Parameter id="iOAdDYlbwUCVeCEKYrkKkA" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_lil" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                             </Parameter>
-                            <Parameter id="QmQ9xTSsZEW2GMBwNbU1CQ" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                            <Parameter id="gk1L3mBefUKHD0OHOeNduw" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
                               <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                             </Parameter>
                           </Children>
                         </Container>
                       </Children>
                     </Container>
-                    <Container id="2xeWyJJpNUmq5vkQLpYIlQ" name="MoleculeProperties" mode="Logical" containerType="Molecule" />
+                    <Container id="KCeJ9XrMVkqJO-ks3latEA" name="MoleculeProperties" mode="Logical" containerType="Molecule" />
                   </Children>
                 </Container>
               </Children>
             </Container>
           </Children>
         </Container>
-        <Container id="O5M9AA2XCE63691KgBV1ew" name="LargeIntestine" mode="Logical" containerType="Organ">
+        <Container id="XBYyoOjndkyK6e14CffQew" name="LargeIntestine" mode="Logical" containerType="Organ">
           <Tags>
             <Tag value="Portal Vein Supplying Organ" />
             <Tag value="TissueOrgan" />
           </Tags>
           <Children>
-            <Parameter id="j1gJGFipqE2nS1YVgwUbjw" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
+            <Parameter id="96JgRQs3UkuzlR3dbKTnLw" name="Large intestinal transit time factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_LITT_Factor" isDefault="1">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
-              <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
+              <Info min="0" flag="38" seq="1" ref="0" bb="32" group="46" />
             </Parameter>
-            <Parameter id="NQ7OxiupekiqKxVM0sv9eg" name="Volume (mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="MucosaVolume.VOLUME_LargeIntestineMucosa" isDefault="1" displayUnit="l">
+            <Parameter id="1MDWd7W9kUyb6vTj0TTbsQ" name="Volume (mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="MucosaVolume.VOLUME_LargeIntestineMucosa" isDefault="1" displayUnit="l">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" flag="62" seq="1" ref="0" bb="32" group="129" />
             </Parameter>
-            <Parameter id="UvfEw3iHtUCwnsI2gaAjxg" name="Large intestinal transit time factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_LITT_Factor" isDefault="1">
+            <Parameter id="N8MAIoy2M06tqtuZC7HlgQ" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
-              <Info min="0" flag="38" seq="1" ref="0" bb="32" group="46" />
+              <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
             </Parameter>
-            <Parameter id="FCXi5PhqGkmxe7fo63MBbQ" name="Fluid recirculation flow rate (incl. mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate" isDefault="1" displayUnit="l/min">
+            <Parameter id="RNGU9BwlQkajy1FWy2uMmQ" name="Fluid recirculation flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_FluidRecirculationRate_lin" isDefault="1" displayUnit="l/min">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-              <Info min="0" flag="122" seq="16" ref="0" bb="32" group="27" />
+              <Info min="0" flag="62" seq="16" ref="0" bb="32" group="27" />
             </Parameter>
-            <Parameter id="pZ8Rz8LjK0GWMYKEzP6qKQ" name="Volume (endothelium)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="VascularEndoVolume.VOLUME_VascularEndo_lin" isDefault="1" displayUnit="l">
+            <Parameter id="fjRZTYgOBEa1U5M6vmwYug" name="Fluid recirculation flow rate (incl. mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate" isDefault="1" displayUnit="l/min">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
-              <Info min="0" flag="62" seq="16" ref="0" bb="32" group="127" />
+              <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+              <Info min="0" flag="122" seq="16" ref="0" bb="32" group="27" />
             </Parameter>
-            <Parameter id="OseYh8W-7UusuLoqThXBuQ" name="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_Lymph_lin" isDefault="1" displayUnit="l/min">
+            <Parameter id="y3lKc6iQc0GR87VgHDTjzQ" name="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_Lymph_lin" isDefault="1" displayUnit="l/min">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
@@ -8589,7 +8647,7 @@
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
               <Info min="0" flag="62" seq="16" ref="0" bb="32" group="58" />
             </Parameter>
-            <Parameter id="xUj_q6lRTEW4TyLjtRLuVA" name="Lymph flow rate (incl. mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Lymph_flow_rate" isDefault="1" displayUnit="l/min">
+            <Parameter id="h6PqK6GbBESRndxhTD7BSw" name="Lymph flow rate (incl. mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Lymph_flow_rate" isDefault="1" displayUnit="l/min">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
@@ -8597,155 +8655,154 @@
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
               <Info min="0" flag="122" seq="16" ref="0" bb="32" group="58" />
             </Parameter>
-            <Parameter id="NUvci_Xt3k6aDi3ZHn7mqw" name="Fluid recirculation flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_FluidRecirculationRate_lin" isDefault="1" displayUnit="l/min">
+            <Parameter id="vLjjZGVIk0iUpUOJ5ncfQw" name="Volume (endothelium)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="VascularEndoVolume.VOLUME_VascularEndo_lin" isDefault="1" displayUnit="l">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
-              <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-              <Info min="0" flag="62" seq="16" ref="0" bb="32" group="27" />
+              <Info min="0" flag="62" seq="16" ref="0" bb="32" group="127" />
             </Parameter>
-            <Parameter id="-wAxk3mU4EmR0jR__IhorQ" name="Fraction intracellular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_f_cell" isDefault="1">
+            <Parameter id="qS0Py3rfBUqN33y5xepMoQ" name="Fraction intracellular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_f_cell" isDefault="1">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" max="1" flag="62" seq="49" ref="0" bb="32" group="64" />
             </Parameter>
-            <Parameter id="Z3juEnKDHE-ysH_0TGRM8Q" name="Blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_from_Qspec" isDefault="1" displayUnit="l/min">
+            <Parameter id="PmBaKzt8OEGXMiX7Kbqlow" name="Blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_from_Qspec" isDefault="1" displayUnit="l/min">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
-              <ValueOrigin id="48" description="TODO: Absolute from specific calculation" />
+              <ValueOrigin id="48" source="Other" description="Absolute value = specific value (i.e. value normalized to the volume of the organ) multiplied by the organ volume" />
               <Info min="0" flag="62" seq="122" ref="0" bb="32" group="5" />
             </Parameter>
-            <Parameter id="C8ncF3kZi0umV-l3YfbeCw" name="Organ volume mouse" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.000627" displayUnit="l">
+            <Parameter id="OouoV5L5s0Krv_RO8W4xag" name="Density (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
-              <Info min="0" flag="54" seq="1" ref="0" bb="32" group="65" />
+              <Info min="0" flag="38" seq="1" ref="0" bb="32" group="21" />
             </Parameter>
-            <Parameter id="ZBy1kUiJQ0GEi3noJbFFsQ" name="Density (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
+            <Parameter id="aetJ0sZdWU2zQ340ijcqGA" name="Fluid recirculation flow proportionality factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.179">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
-              <Info min="0" flag="38" seq="1" ref="0" bb="32" group="21" />
+              <Info min="0" flag="54" seq="1" ref="0" bb="32" group="27" />
             </Parameter>
-            <Parameter id="jOpnrpdAz0SNe6T2fXS6Qw" name="Fluid recirculation flow proportionality factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.179">
+            <Parameter id="BpupmB-sE0-FN7ev3g_74Q" name="Lymph flow proportionality factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0144">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
-              <Info min="0" flag="54" seq="1" ref="0" bb="32" group="27" />
+              <Info min="0" flag="54" seq="1" ref="0" bb="32" group="58" />
             </Parameter>
-            <Parameter id="evm5ewGhwUS_wajyiKCwCg" name="Lymph flow proportionality factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0144">
+            <Parameter id="v3di9SaVjUSlrlT8ozT80A" name="Organ volume mouse" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.000627" displayUnit="l">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
-              <Info min="0" flag="54" seq="1" ref="0" bb="32" group="58" />
+              <Info min="0" flag="54" seq="1" ref="0" bb="32" group="65" />
             </Parameter>
-            <Parameter id="IIyP53U0eE-yZDdr3_9zmA" name="Allometric scale factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.75">
+            <Parameter id="--p6kQePeUW1Hz-1eowHGg" name="Allometric scale factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.75">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0.75" max="0.75" flag="54" seq="1" ref="0" bb="32" group="2" />
             </Parameter>
-            <Parameter id="VhpysyE6uki-bv-P6huAwQ" name="Mucosa blood flow fraction" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.75">
+            <Parameter id="KbiMGpVRnEGPc7H9CjH8EQ" name="Large intestinal transit time factor intercept" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="47.6">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
-              <Info min="0" flag="54" seq="1" ref="0" bb="32" group="39" />
+              <Info flag="52" seq="1" ref="0" bb="32" group="46" />
             </Parameter>
-            <Parameter id="91cWJxGIvEuJuwVSs9zszA" name="Large intestinal transit time factor slope" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.938" displayUnit="1/min">
+            <Parameter id="9kUBaOqJ6km32YACnX1qMA" name="Large intestinal transit time factor slope" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.938" displayUnit="1/min">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info flag="52" seq="1" ref="0" bb="32" group="46" />
             </Parameter>
-            <Parameter id="nUqcpUXmUkmJdpZrC3ZBQg" name="Large intestinal transit time factor intercept" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="47.6">
+            <Parameter id="Rzm6WfTQQEC-5tAinBteew" name="Mucosa blood flow fraction" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.75">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
-              <Info flag="52" seq="1" ref="0" bb="32" group="46" />
+              <Info min="0" flag="54" seq="1" ref="0" bb="32" group="39" />
             </Parameter>
-            <Parameter id="bRI0tXif-EmYMPiDsOaNnQ" name="Fraction of blood for sampling" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+            <Parameter id="kdZcRoiZ1E-he_BtfTzLxA" name="Fraction of blood for sampling" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" max="1" flag="54" seq="1" ref="0" bb="32" group="94" />
             </Parameter>
-            <Parameter id="LJ21qk5nVkObqDlU1McRFw" name="Radius (large pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.5E-07" displayUnit="µm">
+            <Parameter id="qHUrMjh3uUirL-5tw18Usg" name="Flow fraction via large pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.05">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-              <Info min="0" flag="122" seq="16" ref="0" bb="32" group="55" />
+              <Info min="0" max="1" flag="122" seq="16" ref="0" bb="32" group="114" />
             </Parameter>
-            <Parameter id="AuMVdJx0v0SX_5cYUzx1LQ" name="Flow fraction via large pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.05">
+            <Parameter id="mwMnMHnjSk6JKOJh9GVfdA" name="Hydraulic conductivity" icon="Parameter" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.86944444444444E-10" displayUnit="ml/min/N">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-              <Info min="0" max="1" flag="122" seq="16" ref="0" bb="32" group="114" />
+              <Info min="0" flag="122" seq="16" ref="0" bb="32" group="115" />
             </Parameter>
-            <Parameter id="C0WiAkYSuUGVaz4lWBGO9A" name="Radius (small pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="4.5E-08" displayUnit="µm">
+            <Parameter id="OPJql8hDH0mpPCCJBkZ0cQ" name="Radius (large pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.5E-07" displayUnit="µm">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-              <Info min="0" flag="122" seq="16" ref="0" bb="32" group="99" />
+              <Info min="0" flag="122" seq="16" ref="0" bb="32" group="55" />
             </Parameter>
-            <Parameter id="HDJihZBiE0uOJy9TOxmRpw" name="Hydraulic conductivity" icon="Parameter" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.86944444444444E-10" displayUnit="ml/min/N">
+            <Parameter id="y1lxAt-gokeba7VhJvG6wQ" name="Radius (small pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="4.5E-08" displayUnit="µm">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-              <Info min="0" flag="122" seq="16" ref="0" bb="32" group="115" />
+              <Info min="0" flag="122" seq="16" ref="0" bb="32" group="99" />
             </Parameter>
-            <Parameter id="2xEIUXfOEU2ZUEKC_wkTMg" name="Vf (lipid)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.062">
+            <Parameter id="ROMf7XhOIEefXAlmuLG2kw" name="Fraction vascular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.024">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
-              <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
-              <Info min="0" max="1" flag="122" seq="48" ref="0" bb="32" group="85" />
+              <ValueOrigin id="19" source="Publication" description="Kawai R, Lemaire M, Steimer JL, Bruelisauer A, Niederberger W, Rowland M. Physiologically based pharmacokinetic study on a cyclosporin derivative, SDZ IMM 125. J Pharmacokinet Biopharm. 1994 Oct;22(5):327-65." />
+              <Info min="0" max="1" flag="62" seq="48" ref="0" bb="32" group="64" />
             </Parameter>
-            <Parameter id="Sq8a5GtmfUSMwDbpTmficw" name="Vf (neutral lipid)-PT" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0487">
+            <Parameter id="hIrx_rUlxEW5eqUZUQL2og" name="Vf (lipid)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.062">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
-              <Info min="0" max="1" flag="122" seq="48" ref="0" bb="32" group="86" />
+              <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
+              <Info min="0" max="1" flag="122" seq="48" ref="0" bb="32" group="85" />
             </Parameter>
-            <Parameter id="MJw_uwow40WKdzz3kQLLBA" name="Fraction vascular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.024">
+            <Parameter id="RsAXLcKdGUyXD80Dh-FUdA" name="Vf (neutral lipid)-PT" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0487">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
-              <ValueOrigin id="19" source="Publication" description="Kawai R, Lemaire M, Steimer JL, Bruelisauer A, Niederberger W, Rowland M. Physiologically based pharmacokinetic study on a cyclosporin derivative, SDZ IMM 125. J Pharmacokinet Biopharm. 1994 Oct;22(5):327-65." />
-              <Info min="0" max="1" flag="62" seq="48" ref="0" bb="32" group="64" />
+              <Info min="0" max="1" flag="122" seq="48" ref="0" bb="32" group="86" />
             </Parameter>
-            <Parameter id="AdaCvTwEY0ij1zIovrgUtQ" name="Vf (phospholipid)-PT" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0163">
+            <Parameter id="wrEzW8hJAki_CH3uqe7i8g" name="Vf (phospholipid)-PT" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0163">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" max="1" flag="122" seq="49" ref="0" bb="32" group="86" />
             </Parameter>
-            <Parameter id="APy1J0Nzr0qZs7MqoiGWmA" name="Vf (protein)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.133">
+            <Parameter id="m-bZdunDqkSB75VtFDrk0A" name="Vf (protein)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.133">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
@@ -8753,7 +8810,15 @@
               <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
               <Info min="0" max="1" flag="122" seq="49" ref="0" bb="32" group="85" />
             </Parameter>
-            <Parameter id="5fniQZxeiE-UmUaX8HOhPQ" name="Albumin ratio (tissue/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.158">
+            <Parameter id="e78DKHQVNUmwXGsHC_l3PQ" name="Fraction interstitial" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.094">
+              <Tags>
+                <Tag value="Portal Vein Supplying Organ" />
+                <Tag value="TissueOrgan" />
+              </Tags>
+              <ValueOrigin id="19" source="Publication" description="Kawai R, Lemaire M, Steimer JL, Bruelisauer A, Niederberger W, Rowland M. Physiologically based pharmacokinetic study on a cyclosporin derivative, SDZ IMM 125. J Pharmacokinet Biopharm. 1994 Oct;22(5):327-65." />
+              <Info min="0" max="1" flag="62" seq="50" ref="0" bb="32" group="64" />
+            </Parameter>
+            <Parameter id="gVVuQ2pyxU-qJ0t85_ivnQ" name="Albumin ratio (tissue/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.158">
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+            <Parameter id="Vw16x3vksEKHm08GaenhEQ" name="Albumin ratio (tissue/plasma)-PT" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
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+            <Parameter id="nGCCX0QlekK1BUIJIMZtlQ" name="Lipoprotein ratio (tissue/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.141">
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+            <Parameter id="UlNEBtW9LEew-HGBlRm7Jg" name="Vf (neutral lipid)-WS" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0483">
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+            <Parameter id="fHekUHBqYUivuEBkWLO7ow" name="Vf (neutral phospholipid)-RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0124">
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+            <Parameter id="5UkrdiD7s0--SKg4gmOFzA" name="Vf (neutral phospholipid, plasma)-WS" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0182">
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                 <Tag value="TissueOrgan" />
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-              <Info min="0" max="1" flag="122" seq="82" ref="0" bb="32" group="95" />
+              <Info min="0" max="1" flag="122" seq="81" ref="0" bb="32" group="95" />
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-            <Parameter id="hPa41SvgRUKsyfmRi2SWYg" name="Vf (extracellular water)-RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.282">
+            <Parameter id="i709aKQrNU2nTqPBeaVNhA" name="Vf (extracellular water)-RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.282">
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                 <Tag value="TissueOrgan" />
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+            <Parameter id="r0jmoPUd8keaueKiRMXkiw" name="Vf (intracellular water)-RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.456">
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+            <Parameter id="Dbm1D64bxEKq0tQ0UpLUAA" name="Vf (water)-WS" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.78">
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                 <Tag value="TissueOrgan" />
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-              <Info min="0" max="1" flag="122" seq="84" ref="0" bb="32" group="95" />
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+            <Parameter id="pN_zrpo1_kSiwa18O2ZnIA" name="Acidic phospholipids [mg/g] - RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.41">
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+            <Parameter id="QbGhSM2aQUe0gtDXB-8PiA" name="Vf (acidic phospholipids)-WS" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0035">
+              <Tags>
+                <Tag value="Portal Vein Supplying Organ" />
+                <Tag value="TissueOrgan" />
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+              <Info min="0" max="1" flag="122" seq="84" ref="0" bb="32" group="95" />
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+                <Parameter id="frTZcnfl8EeUMSquvdvtog" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5" displayUnit="h">
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+                <Parameter id="3InhDYu8lUOCvyq3I5-eVg" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2652" displayUnit="h">
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@@ -8890,15 +8947,15 @@
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+            <DistributedParameter id="8KHCeQAozk62Sbr9FMZYFg" name="Volume" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="u9RTLKc0c0qLe0dSbG71fg" mode="Logical" isDefault="1" displayUnit="l">
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+                <Parameter id="JGVnr-CR5kWwaKGV1BQ-nQ" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.501964262652174" displayUnit="l">
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+                <Parameter id="hDhvSrv0iESt4YJaDmcuCQ" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.41217159744" displayUnit="l">
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+                <Parameter id="bggCh2HY4k-6jEoOev_SEw" name="Deviation" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.080576347522488" displayUnit="l">
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@@ -8906,17 +8963,18 @@
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
+              <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
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+            <DistributedParameter id="xB7DxIsaAk-5GkWWPElHmA" name="Specific blood flow rate" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" formula="6_3KPGtg8kehyqxrPNtwtg" mode="Logical" isDefault="1" displayUnit="ml/min/100g organ">
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+                <Parameter id="9wIC5_HBsk6Jn8Y2laswDQ" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5" displayUnit="ml/min/100g organ">
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+                <Parameter id="Mv-gAZObJEynUKRvmYWmVg" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.6305" displayUnit="ml/min/100g organ">
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+                <Parameter id="yjFf4Bg8pEiOuDkDMtwTEQ" name="Deviation" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.031525" displayUnit="ml/min/100g organ">
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@@ -8924,338 +8982,339 @@
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
+              <ValueOrigin id="40" source="Publication" description="Edginton, A.N., Schmitt, W. &amp; Willmann, S. Clin Pharmacokinet (2006) 45: 1013. https://doi.org/10.2165/00003088-200645100-00005" />
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             </DistributedParameter>
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               <Tags>
                 <Tag value="LargeIntestine" />
                 <Tag value="Portal Vein Supplying Organ" />
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+                <Parameter id="2oYMqcBuYkytof3zTnBNVw" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
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+                <Parameter id="K6j0QrK7JkmJDRsWsPpqIg" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_pls_SinLin" isDefault="1" displayUnit="l">
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                               <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                             </Parameter>
                           </Children>
                         </Container>
                       </Children>
                     </Container>
-                    <Container id="TZOfiNQfs0GwnASXrHgFkw" name="BloodCells" mode="Physical" containerType="Compartment">
+                    <Container id="NugBHVuOHEervTrkBVs4wg" name="BloodCells" mode="Physical" containerType="Compartment">
                       <Tags>
                         <Tag value="Caecum" />
                         <Tag value="LargeIntestineSegment" />
                         <Tag value="Mucosa" />
                       </Tags>
                       <Children>
-                        <Parameter id="8QZmkT-AWEOWYBiWBkr-ww" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                        <Parameter id="h9UeLTVIlk2WuYlbVnUA3A" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
                           <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                         </Parameter>
-                        <Parameter id="fUo_e4WTcUan8yc4D27CaQ" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" isDefault="1" displayUnit="l">
+                        <Parameter id="3_dBi5WqekyLvBwE_s3B7w" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" isDefault="1" displayUnit="l">
                           <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                           <Info min="0" flag="62" seq="116" ref="0" bb="2" group="121" />
                         </Parameter>
-                        <Container id="9argyHto6E-KUjEAVRIS0w" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                        <Container id="3YtNn58os0eUjFPdHrilEw" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                           <Children>
-                            <Parameter id="gzRUxtJZkEOFbhKnXE9Y-g" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                            <Parameter id="u84xPdo3eUqLjMJ_F-kwtg" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                             </Parameter>
-                            <Parameter id="d1oDDmw6ZE2KxVbjfHvWNg" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" isDefault="1">
+                            <Parameter id="PJLSdzM1ZkWTJ2Isw1Pl4A" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                             </Parameter>
-                            <Parameter id="CEjB_S-O-U6EsQtrZ0yCWA" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                            <Parameter id="UBAxjODgD0uY9gsZvUAqjA" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
                               <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                             </Parameter>
                           </Children>
                         </Container>
                       </Children>
                     </Container>
-                    <Container id="beNTDbQolEqO-97pd3G3og" name="Interstitial" mode="Physical" containerType="Compartment">
+                    <Container id="xBafoBV-d0yCjOUqux2Enw" name="Interstitial" mode="Physical" containerType="Compartment">
                       <Tags>
                         <Tag value="Caecum" />
                         <Tag value="LargeIntestineSegment" />
                         <Tag value="Mucosa" />
                       </Tags>
                       <Children>
-                        <Parameter id="tUQOe1uaLk2gaWNoO5k_pQ" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                        <Parameter id="uEkl6EQl4Eq6UZoBURgXFA" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
                           <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                         </Parameter>
-                        <Parameter id="J8ZZKB3KuE2RwHdZ66dQYg" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" isDefault="1" displayUnit="l">
+                        <Parameter id="tHUxlpVcw0ywXsq4VYWwVg" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" isDefault="1" displayUnit="l">
                           <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                           <Info min="0" flag="62" seq="116" ref="0" bb="2" group="124" />
                         </Parameter>
-                        <Parameter id="VTF7C4QmTku1Od3fKN_TWA" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_pH_INT" isDefault="1">
+                        <Parameter id="7K_AXYTp-kWl91Sid-Y6bA" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_pH_INT" isDefault="1">
                           <Tags>
                             <Tag value="Caecum" />
                             <Tag value="LargeIntestineSegment" />
@@ -9263,22 +9322,22 @@
                           </Tags>
                           <Info min="0" max="14" flag="122" seq="350" ref="0" bb="32" group="84" />
                         </Parameter>
-                        <Container id="TFOx9bTk8E-0BMcwaSGAGw" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                        <Container id="1QgdewxTcU2eRHJJ6d-Crg" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                           <Children>
-                            <Parameter id="duKK7R7s_kStxNlM6WKgHQ" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                            <Parameter id="47Wkl1A1pkuf6Jp6QwHUMg" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                             </Parameter>
-                            <Parameter id="py2pGQ2NXEuSNSVd9ZD14A" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_cae" isDefault="1">
+                            <Parameter id="B1lp7deBlEeqecvDSJhFRw" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_cae" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                             </Parameter>
-                            <Parameter id="tql-tlvOzk6KVFp58_-D6Q" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                            <Parameter id="Pv8socOCk0S6ht205mCnng" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
                               <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                             </Parameter>
                           </Children>
                         </Container>
                       </Children>
                     </Container>
-                    <Container id="Si0F6PmVv0qRnmm7cbWb5A" name="Intracellular" mode="Physical" containerType="Compartment">
+                    <Container id="9T8VbJMx3kaUZwobqt8v9w" name="Intracellular" mode="Physical" containerType="Compartment">
                       <Tags>
                         <Tag value="Caecum" />
                         <Tag value="IntestinalSecretionSource" />
@@ -9286,14 +9345,14 @@
                         <Tag value="Mucosa" />
                       </Tags>
                       <Children>
-                        <Parameter id="RTPzlvurkU-0yIlEW8C5fQ" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" isDefault="1" displayUnit="l">
+                        <Parameter id="_W32jALPi0WkcgPC_mS9xg" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" isDefault="1" displayUnit="l">
                           <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                         </Parameter>
-                        <Parameter id="hRiGgsR150mbsrYKYBrkCA" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" isDefault="1" displayUnit="l">
+                        <Parameter id="M1Q6W6gExUORZExjFaad2g" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" isDefault="1" displayUnit="l">
                           <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                           <Info min="0" flag="62" seq="116" ref="0" bb="2" group="125" />
                         </Parameter>
-                        <Parameter id="UtyA3vUFcE6uUE74vid-7g" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.3">
+                        <Parameter id="jED5k_ptMkmxTBF1bHR3Uw" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.3">
                           <Tags>
                             <Tag value="Caecum" />
                             <Tag value="IntestinalSecretionSource" />
@@ -9303,226 +9362,226 @@
                           <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
                           <Info min="0" max="14" flag="122" seq="350" ref="0" bb="32" group="83" />
                         </Parameter>
-                        <Container id="h72wbgH7okqb4io_EdDrfg" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                        <Container id="DtKMkPOM_ECqLGKZXJHpyg" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                           <Children>
-                            <Parameter id="TG64KpkLjkG0iEZsKDnYbg" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                            <Parameter id="4yClZmk7VESHIhPQ8Y1znA" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                             </Parameter>
-                            <Parameter id="pKi6I1XPD0KTkqeAxLWZvA" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_cae" isDefault="1">
+                            <Parameter id="JLMVkR98_06TOuytsHRpxA" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_cae" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                             </Parameter>
-                            <Parameter id="Maxv8oWbPkeOcxkYybUSjg" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                            <Parameter id="z09YJtEmpEOs_7YnRNfH8g" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
                               <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                             </Parameter>
                           </Children>
                         </Container>
                       </Children>
                     </Container>
-                    <Container id="yeU47xmi-U2-xRdVaZAWpw" name="MoleculeProperties" mode="Logical" containerType="Molecule" />
+                    <Container id="FZE5zyc3Iku0AZeupzf_gA" name="MoleculeProperties" mode="Logical" containerType="Molecule" />
                   </Children>
                 </Container>
-                <Container id="sY-uP0Ox4kerZr08UFiqlQ" name="ColonAscendens" mode="Logical" containerType="Compartment">
+                <Container id="Hjhm-7yENkSZEj5CXZid2g" name="ColonAscendens" mode="Logical" containerType="Compartment">
                   <Children>
-                    <Parameter id="G6pxnJzB3kKArZFP-3AVpw" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
+                    <Parameter id="2-DNM2VBUEqolNYQxnKPlg" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
                       <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
                     </Parameter>
-                    <Parameter id="zyBvNmYeBkClEvJNMc2oow" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="MucosaVolume.VOLUME_MucosaColonAscendens" isDefault="1" displayUnit="l">
+                    <Parameter id="oym5zayXwEKzqN8aedeBnA" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="MucosaVolume.VOLUME_MucosaColonAscendens" isDefault="1" displayUnit="l">
                       <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
                       <Info min="0" flag="122" seq="26" ref="0" bb="32" group="65" />
                     </Parameter>
-                    <Parameter id="fmxVNNfqjkGpAuK5-2uLMg" name="Volume (endothelium)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="VascularEndoVolume.VOLUME_VascularEndo_colasc" isDefault="1" displayUnit="l">
-                      <Info min="0" flag="62" seq="117" ref="0" bb="32" group="127" />
+                    <Parameter id="5fSoBiPfgk-Siuo_kllxGQ" name="Fluid recirculation flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_J_iso_Mucosa" isDefault="1" displayUnit="l/min">
+                      <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                      <Info min="0" flag="122" seq="117" ref="0" bb="32" group="27" />
                     </Parameter>
-                    <Parameter id="vr7Bn8aUkkSLkE35vK79dA" name="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_lymph_mucosa" isDefault="1" displayUnit="l/min">
+                    <Parameter id="ayc5mFFPfUK7l_5U2vIFow" name="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_lymph_mucosa" isDefault="1" displayUnit="l/min">
                       <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                       <Info min="0" flag="122" seq="117" ref="0" bb="32" group="58" />
                     </Parameter>
-                    <Parameter id="KZpZFHlK3k6LV5d3osK9Ug" name="Fluid recirculation flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_J_iso_Mucosa" isDefault="1" displayUnit="l/min">
-                      <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-                      <Info min="0" flag="122" seq="117" ref="0" bb="32" group="27" />
+                    <Parameter id="Wr2oLEZW5Umlmamx8UOn4g" name="Volume (endothelium)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="VascularEndoVolume.VOLUME_VascularEndo_colasc" isDefault="1" displayUnit="l">
+                      <Info min="0" flag="62" seq="117" ref="0" bb="32" group="127" />
                     </Parameter>
-                    <Parameter id="jHqC9qvwcE6XIC_ExEUTfQ" name="Blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_mucosa" isDefault="1" displayUnit="l/min">
+                    <Parameter id="uJjwL92ZUEygqZSM7_SojQ" name="Blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_mucosa" isDefault="1" displayUnit="l/min">
                       <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
                       <Info min="0" flag="122" seq="306" ref="0" bb="32" group="5" />
                     </Parameter>
-                    <Parameter id="mPe4rCkdj0iU38lm_muwEQ" name="Fraction intracellular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_f_cell" isDefault="1">
+                    <Parameter id="KZy-QKLNL0q4G90FCQGBcA" name="Fraction intracellular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_f_cell" isDefault="1">
                       <Info min="0" max="1" flag="62" seq="352" ref="0" bb="32" group="64" />
                     </Parameter>
-                    <Parameter id="n36A0NmAUkKxoNz0kd4b7w" name="Density (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
+                    <Parameter id="w0-6myP3IEuLdORVD__BRA" name="Density (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
                       <Info min="0" flag="38" seq="1" ref="0" bb="32" group="21" />
                     </Parameter>
-                    <Parameter id="sLlHN88N6U2xmtrITB4U-g" name="Fraction mucosa" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.19">
-                      <Info min="0" max="1" flag="58" seq="1" ref="0" bb="32" group="40" />
+                    <Parameter id="Rar4fExpaUa4kJa9KmcEcg" name="Fraction mucosa" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.19">
+                      <Info min="0" max="1" flag="122" seq="1" ref="0" bb="32" group="40" />
                     </Parameter>
-                    <Parameter id="TwqlqetVv0-tvVA6VXw_cQ" name="Fraction of regional blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.15529">
+                    <Parameter id="pUXxh2o9-UGR3BXIbROP2Q" name="Fraction of regional blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.15529">
                       <Info min="0" flag="54" seq="1" ref="0" bb="32" group="39" />
                     </Parameter>
-                    <Parameter id="pQjdE7FiiEaimNjdXThOYQ" name="Fraction of blood for sampling" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                    <Parameter id="i_a6UXxaOUOeTjlAtQLh2w" name="Fraction of blood for sampling" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
                       <Info min="0" max="1" flag="54" seq="1" ref="0" bb="32" group="94" />
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-                        <Parameter id="p781xkZK6keEbLQNl6PsyQ" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                        <Parameter id="Na0DMZveXUWoX6gTUbs2WA" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
                           <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                         </Parameter>
-                        <Parameter id="DCT-NnnUT0uO2cZHgT0GFQ" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" isDefault="1" displayUnit="l">
+                        <Parameter id="qewLtWH9HkCBfG0fOYSOJQ" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" isDefault="1" displayUnit="l">
                           <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                           <Info min="0" flag="62" seq="117" ref="0" bb="2" group="121" />
                         </Parameter>
-                        <Container id="41EtY4eqZE6MtA5Y1PYamQ" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                        <Container id="Z6ZizPk1ZUq6zm4XBhAO8A" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                           <Children>
-                            <Parameter id="AsKgPODhBEmNxsHhSPzJeQ" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                            <Parameter id="MPLaj7M5kE2QspLjHxjvdQ" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                             </Parameter>
-                            <Parameter id="yUa2B7HSIUaUTuTxOPKYdg" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" isDefault="1">
+                            <Parameter id="msz3Jnac3U21wa2gxHqW5g" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                             </Parameter>
-                            <Parameter id="37i0RaIsCkOgQoYx9k9nDQ" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                            <Parameter id="8cePU9WyI0iPvwnIIjzBiA" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
                               <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                             </Parameter>
                           </Children>
                         </Container>
                       </Children>
                     </Container>
-                    <Container id="_RrXg5iGA0abZtIK9opnGQ" name="Interstitial" mode="Physical" containerType="Compartment">
+                    <Container id="S9HSD1S7I0S6TZw_WfUqFg" name="Interstitial" mode="Physical" containerType="Compartment">
                       <Tags>
                         <Tag value="ColonAscendens" />
                         <Tag value="LargeIntestineSegment" />
                         <Tag value="Mucosa" />
                       </Tags>
                       <Children>
-                        <Parameter id="WnfbyqDdREyHWoxeMEjxeA" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                        <Parameter id="aA2gF1IsQEix3_QyB0ZXCQ" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
                           <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                         </Parameter>
-                        <Parameter id="SYss5SwKgkOnHc3sKDgvhA" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" isDefault="1" displayUnit="l">
+                        <Parameter id="LLwpdnYag0S6mRutyFTMMw" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" isDefault="1" displayUnit="l">
                           <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                           <Info min="0" flag="62" seq="117" ref="0" bb="2" group="124" />
                         </Parameter>
-                        <Parameter id="np8IVa_w6kqti-oP_Tz9Xw" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_pH_INT" isDefault="1">
+                        <Parameter id="_TPDfObfZ0eMhq0Xbjy_cQ" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_pH_INT" isDefault="1">
                           <Tags>
                             <Tag value="ColonAscendens" />
                             <Tag value="LargeIntestineSegment" />
@@ -9530,22 +9589,22 @@
                           </Tags>
                           <Info min="0" max="14" flag="122" seq="353" ref="0" bb="32" group="84" />
                         </Parameter>
-                        <Container id="J05k2dz-qEqaaWFbGtx3QA" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                        <Container id="7Fmu7xCUPkSriQjfj2GtbQ" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                           <Children>
-                            <Parameter id="wT71C5ioGEinwVa_Vebqvw" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                            <Parameter id="hDVFjPUda02LFfoocN1W0A" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                             </Parameter>
-                            <Parameter id="dsUSXhej_ECwgrGQhPRA-w" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_colasc" isDefault="1">
+                            <Parameter id="mCxBzWTUKUyw6TNavaQlbg" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_colasc" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                             </Parameter>
-                            <Parameter id="cB51XF9fQUeu-XSFxDOA8Q" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                            <Parameter id="rbkWRRmkP0i-Ty5EAwczbQ" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
                               <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                             </Parameter>
                           </Children>
                         </Container>
                       </Children>
                     </Container>
-                    <Container id="xgXczYdZrE692wGtlg0fgA" name="Intracellular" mode="Physical" containerType="Compartment">
+                    <Container id="WLbI5Rdu60Wk9X8eKNb3tg" name="Intracellular" mode="Physical" containerType="Compartment">
                       <Tags>
                         <Tag value="ColonAscendens" />
                         <Tag value="IntestinalSecretionSource" />
@@ -9553,14 +9612,14 @@
                         <Tag value="Mucosa" />
                       </Tags>
                       <Children>
-                        <Parameter id="U5Csx4H77k2jq-1_KymLOw" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" isDefault="1" displayUnit="l">
+                        <Parameter id="8O_qUyXosE2a0P5dPLFFnw" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" isDefault="1" displayUnit="l">
                           <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                         </Parameter>
-                        <Parameter id="Gq9wMEvjEUuTLwmwzrXujg" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" isDefault="1" displayUnit="l">
+                        <Parameter id="gu5fDJtMrky6-kTbeOcE_g" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" isDefault="1" displayUnit="l">
                           <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                           <Info min="0" flag="62" seq="117" ref="0" bb="2" group="125" />
                         </Parameter>
-                        <Parameter id="10TVeL8YEUuqRWHy_kCuSQ" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.3">
+                        <Parameter id="YFr8gDuDh06QzaPKBjp-GQ" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.3">
                           <Tags>
                             <Tag value="ColonAscendens" />
                             <Tag value="IntestinalSecretionSource" />
@@ -9570,226 +9629,226 @@
                           <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
                           <Info min="0" max="14" flag="122" seq="353" ref="0" bb="32" group="83" />
                         </Parameter>
-                        <Container id="iy1JsNkJUUmZ_lQMyAhcEQ" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                        <Container id="G8nFw9UF6kK6behog5DAmA" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                           <Children>
-                            <Parameter id="iU8S33WSJUiFT5C2c40xBA" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                            <Parameter id="C9TJSjR8IkukHE9GHe_0Mg" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                             </Parameter>
-                            <Parameter id="Ac3nSxdArE2HEZFO4kBPKA" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_colasc" isDefault="1">
+                            <Parameter id="2TtGqv7zfUy5XkBpdDlw7w" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_colasc" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                             </Parameter>
-                            <Parameter id="JtFwOd89tUKjkpdthYUMNg" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                            <Parameter id="QLgXNx-Zt02wUTGCCU61Ww" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
                               <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                             </Parameter>
                           </Children>
                         </Container>
                       </Children>
                     </Container>
-                    <Container id="j6PoQsQy_UC8GmLkCMEuXw" name="MoleculeProperties" mode="Logical" containerType="Molecule" />
+                    <Container id="GHL86uyS3k-1XdvHceRoDg" name="MoleculeProperties" mode="Logical" containerType="Molecule" />
                   </Children>
                 </Container>
-                <Container id="vP9L_UvOQE2B67hm5BixZg" name="ColonTransversum" mode="Logical" containerType="Compartment">
+                <Container id="YcJgHsmQDkCb4TuxtYWRWQ" name="ColonTransversum" mode="Logical" containerType="Compartment">
                   <Children>
-                    <Parameter id="WwXAsUAkV02oDCSvPr125w" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
+                    <Parameter id="68-cZa72UUGrDpuUVqQkAg" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
                       <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
                     </Parameter>
-                    <Parameter id="9xizNsaXT0K34Yn0yeNsQw" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="MucosaVolume.VOLUME_MucosaColonTransversum" isDefault="1" displayUnit="l">
+                    <Parameter id="aPVZp394okW7XBuEK5fdiQ" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="MucosaVolume.VOLUME_MucosaColonTransversum" isDefault="1" displayUnit="l">
                       <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
                       <Info min="0" flag="122" seq="27" ref="0" bb="32" group="65" />
                     </Parameter>
-                    <Parameter id="s1liiAET0EinaxjcMKrqGg" name="Volume (endothelium)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="VascularEndoVolume.VOLUME_VascularEndo_coltrans" isDefault="1" displayUnit="l">
-                      <Info min="0" flag="62" seq="118" ref="0" bb="32" group="127" />
+                    <Parameter id="Vuun7oTXDkOPI3lgWGwPGw" name="Fluid recirculation flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_J_iso_Mucosa" isDefault="1" displayUnit="l/min">
+                      <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                      <Info min="0" flag="122" seq="118" ref="0" bb="32" group="27" />
                     </Parameter>
-                    <Parameter id="2l2lmTgOW0C3XhEouvMHXg" name="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_lymph_mucosa" isDefault="1" displayUnit="l/min">
+                    <Parameter id="llTRAt3fgEeynbe3FXicSw" name="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_lymph_mucosa" isDefault="1" displayUnit="l/min">
                       <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                       <Info min="0" flag="122" seq="118" ref="0" bb="32" group="58" />
                     </Parameter>
-                    <Parameter id="3jeFG1ZTYEi84locCnJMvw" name="Fluid recirculation flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_J_iso_Mucosa" isDefault="1" displayUnit="l/min">
-                      <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-                      <Info min="0" flag="122" seq="118" ref="0" bb="32" group="27" />
+                    <Parameter id="ptSnxMWjEE6Eq935Qntfrw" name="Volume (endothelium)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="VascularEndoVolume.VOLUME_VascularEndo_coltrans" isDefault="1" displayUnit="l">
+                      <Info min="0" flag="62" seq="118" ref="0" bb="32" group="127" />
                     </Parameter>
-                    <Parameter id="QEA8YCZ3wkSqkDHCieJzMA" name="Blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_mucosa" isDefault="1" displayUnit="l/min">
+                    <Parameter id="VT4c4wZ1R0WHYAlaeUrTPQ" name="Blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_mucosa" isDefault="1" displayUnit="l/min">
                       <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
                       <Info min="0" flag="122" seq="307" ref="0" bb="32" group="5" />
                     </Parameter>
-                    <Parameter id="V5WfxvK8dkig2MncbAM4ow" name="Fraction intracellular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_f_cell" isDefault="1">
+                    <Parameter id="bltjDTS0LU68b-7T82YpcA" name="Fraction intracellular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_f_cell" isDefault="1">
                       <Info min="0" max="1" flag="62" seq="355" ref="0" bb="32" group="64" />
                     </Parameter>
-                    <Parameter id="CP6poC8KxEee76CvhtgNnQ" name="Density (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
+                    <Parameter id="fFTXEPUA_EOiGv_8XfX7jQ" name="Density (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
                       <Info min="0" flag="38" seq="1" ref="0" bb="32" group="21" />
                     </Parameter>
-                    <Parameter id="jFwXpEHrKU2LvdbGOCAGGw" name="Fraction of regional blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.32">
-                      <Info min="0" flag="54" seq="1" ref="0" bb="32" group="39" />
+                    <Parameter id="AaUKvI2Xt0uY5zIH8vFeAw" name="Fraction mucosa" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.21">
+                      <Info min="0" max="1" flag="122" seq="1" ref="0" bb="32" group="40" />
                     </Parameter>
-                    <Parameter id="nhl6L5KpZk2dvlAIC6E9GQ" name="Fraction mucosa" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.21">
-                      <Info min="0" max="1" flag="58" seq="1" ref="0" bb="32" group="40" />
+                    <Parameter id="2r6b-CQOJ0OPi1ckVuuchQ" name="Fraction of regional blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.32">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="32" group="39" />
                     </Parameter>
-                    <Parameter id="DVkWY1zVIUCYmdXYBhfM4Q" name="Fraction of blood for sampling" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                    <Parameter id="6_7Xgq8fUUSdqb18_FjkEA" name="Fraction of blood for sampling" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
                       <Info min="0" max="1" flag="54" seq="1" ref="0" bb="32" group="94" />
                     </Parameter>
-                    <Parameter id="lm-sSZvPvEG3dFoNr87ZwA" name="Radius (large pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.5E-07" displayUnit="µm">
+                    <Parameter id="YMpgYX2Lxk6V-hHHiWWSHA" name="Flow fraction via large pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.05">
                       <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-                      <Info min="0" flag="122" seq="118" ref="0" bb="32" group="55" />
+                      <Info min="0" max="1" flag="122" seq="118" ref="0" bb="32" group="114" />
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+                        <Parameter id="VC2FCcFsBkarjlWm_skQ6w" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" isDefault="1" displayUnit="l">
                           <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                           <Info min="0" flag="62" seq="118" ref="0" bb="2" group="121" />
                         </Parameter>
-                        <Container id="urqWEoldzkG5BSHpG3Ur0w" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                        <Container id="cjQAu5IXnU6LwOgdVeuQgw" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                           <Children>
-                            <Parameter id="ezWXFrHty02vpD3e5lk5fA" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                            <Parameter id="uU_oKchuCUav8s9i5aF_7Q" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                             </Parameter>
-                            <Parameter id="4Ckuc9L9Nkm_T3NeYStuyA" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" isDefault="1">
+                            <Parameter id="aSmPmHOXl0iL2LppuPCeyA" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                             </Parameter>
-                            <Parameter id="gskCS_MbtE226oTdlyjOMA" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                            <Parameter id="4Gv1Oa8nFUapoN1WZhp0Ng" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
                               <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                             </Parameter>
                           </Children>
                         </Container>
                       </Children>
                     </Container>
-                    <Container id="tKhAurmDF0aooV-Gkc4uiQ" name="Interstitial" mode="Physical" containerType="Compartment">
+                    <Container id="F_A4648Qg0SRyArlhhx5Cg" name="Interstitial" mode="Physical" containerType="Compartment">
                       <Tags>
                         <Tag value="ColonTransversum" />
                         <Tag value="LargeIntestineSegment" />
                         <Tag value="Mucosa" />
                       </Tags>
                       <Children>
-                        <Parameter id="6jzAzNtWf0q9mzVXNea21Q" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                        <Parameter id="U7gCyZqbZ0yR44ASkIfWOQ" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
                           <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                         </Parameter>
-                        <Parameter id="4PAd7b4vvkWh-ebci27mlg" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" isDefault="1" displayUnit="l">
+                        <Parameter id="Vu05HyNUCEaK9EEfcjYrZg" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" isDefault="1" displayUnit="l">
                           <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                           <Info min="0" flag="62" seq="118" ref="0" bb="2" group="124" />
                         </Parameter>
-                        <Parameter id="s_feAnkFdEabcOYqgSWG6w" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_pH_INT" isDefault="1">
+                        <Parameter id="kTty00t69kOddV8-5QBpyg" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_pH_INT" isDefault="1">
                           <Tags>
                             <Tag value="ColonTransversum" />
                             <Tag value="LargeIntestineSegment" />
@@ -9797,22 +9856,22 @@
                           </Tags>
                           <Info min="0" max="14" flag="122" seq="356" ref="0" bb="32" group="84" />
                         </Parameter>
-                        <Container id="UJPwU1wq106ATz54D2vt3A" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                        <Container id="AFxURiUaEk6A5ecmkZb9kg" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                           <Children>
-                            <Parameter id="YSNslErWI0yfP5LSYM-lfQ" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
-                              <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
-                            </Parameter>
-                            <Parameter id="S-oYIGmH7k2tIsfMs58hhw" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                            <Parameter id="0hmh3m2uUke6mrUgls5p7A" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                             </Parameter>
-                            <Parameter id="lKC2E48FF0Kx_7O-z8dVRA" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_coltrans" isDefault="1">
+                            <Parameter id="8Yh6MUu7cEa97TLJPKzqOg" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_coltrans" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                             </Parameter>
+                            <Parameter id="gSaqr96NF06xbd71pLsKVw" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                              <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                            </Parameter>
                           </Children>
                         </Container>
                       </Children>
                     </Container>
-                    <Container id="Wr481BzF70KwAYQOaEn_ag" name="Intracellular" mode="Physical" containerType="Compartment">
+                    <Container id="1UgZYU8R5UWKEifrALKt2w" name="Intracellular" mode="Physical" containerType="Compartment">
                       <Tags>
                         <Tag value="ColonTransversum" />
                         <Tag value="IntestinalSecretionSource" />
@@ -9820,14 +9879,14 @@
                         <Tag value="Mucosa" />
                       </Tags>
                       <Children>
-                        <Parameter id="JdDz0hbHHEiv8NDefZbJzQ" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" isDefault="1" displayUnit="l">
+                        <Parameter id="1wrBCWkUmkKBiWkgTAEN-A" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" isDefault="1" displayUnit="l">
                           <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                         </Parameter>
-                        <Parameter id="AyMorsjceEao4eS_VN2o1A" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" isDefault="1" displayUnit="l">
+                        <Parameter id="nLk8qMpnykSW31PPxPrHcQ" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" isDefault="1" displayUnit="l">
                           <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                           <Info min="0" flag="62" seq="118" ref="0" bb="2" group="125" />
                         </Parameter>
-                        <Parameter id="ztl77Y7kP0OQhYF65-xh2Q" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.3">
+                        <Parameter id="jd3w2J4d4EqwZC8Kl5vQnQ" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.3">
                           <Tags>
                             <Tag value="ColonTransversum" />
                             <Tag value="IntestinalSecretionSource" />
@@ -9837,226 +9896,226 @@
                           <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
                           <Info min="0" max="14" flag="122" seq="356" ref="0" bb="32" group="83" />
                         </Parameter>
-                        <Container id="P8KBbyWXpkukNp8QUI-0Kw" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                        <Container id="HmV--8Iq0Uu4MZqg6fTV1Q" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                           <Children>
-                            <Parameter id="cdvWGlEv20G7GueAkFJAKA" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_coltrans" isDefault="1">
+                            <Parameter id="B9lLXlNWXUaPIK5rBgZ9DQ" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                              <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                            </Parameter>
+                            <Parameter id="AP-K7XWE2kGl2LtpqaPSXQ" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_coltrans" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                             </Parameter>
-                            <Parameter id="KGysB8X6eU-h2qDC-_XwNw" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                            <Parameter id="DyzQY6fnp0m7hMawu7pnTw" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
                               <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                             </Parameter>
-                            <Parameter id="nccZRth-90qJy7WtyrcJrQ" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
-                              <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
-                            </Parameter>
                           </Children>
                         </Container>
                       </Children>
                     </Container>
-                    <Container id="t0Bl_Cvytk6JWR2UhkWS-g" name="MoleculeProperties" mode="Logical" containerType="Molecule" />
+                    <Container id="CBvl_p5CcUOojHLZQPKxCA" name="MoleculeProperties" mode="Logical" containerType="Molecule" />
                   </Children>
                 </Container>
-                <Container id="CJU5EqFNBku45nOpw5Kq-g" name="ColonDescendens" mode="Logical" containerType="Compartment">
+                <Container id="pVtz7mGBJkKRjMk7h4Zlqw" name="ColonDescendens" mode="Logical" containerType="Compartment">
                   <Children>
-                    <Parameter id="eVU7QCGN3kK8_H5rmkYTyA" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
+                    <Parameter id="sP2LH1aEs0KFiwgZWa4jxg" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
                       <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
                     </Parameter>
-                    <Parameter id="LOUJRJE9M0-MNQo1qAm7ZQ" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="MucosaVolume.VOLUME_MucosaColonDescendens" isDefault="1" displayUnit="l">
+                    <Parameter id="lukzuA1QmEOvGWPyHJR8GQ" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="MucosaVolume.VOLUME_MucosaColonDescendens" isDefault="1" displayUnit="l">
                       <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
                       <Info min="0" flag="122" seq="28" ref="0" bb="32" group="65" />
                     </Parameter>
-                    <Parameter id="i90MahEYUk2E6pc_Mf-QbQ" name="Volume (endothelium)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="VascularEndoVolume.VOLUME_VascularEndo_coldesc" isDefault="1" displayUnit="l">
-                      <Info min="0" flag="62" seq="119" ref="0" bb="32" group="127" />
-                    </Parameter>
-                    <Parameter id="aaHAv1IenUOeCN0Hi0_bbQ" name="Fluid recirculation flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_J_iso_Mucosa" isDefault="1" displayUnit="l/min">
+                    <Parameter id="TNswnEO6MkWOUeL3F51HXw" name="Fluid recirculation flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_J_iso_Mucosa" isDefault="1" displayUnit="l/min">
                       <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                       <Info min="0" flag="122" seq="119" ref="0" bb="32" group="27" />
                     </Parameter>
-                    <Parameter id="wqIoPM4HEkarSz-HV839ig" name="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_lymph_mucosa" isDefault="1" displayUnit="l/min">
+                    <Parameter id="BnuXo8rbKEuj3bBXXimRDw" name="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_lymph_mucosa" isDefault="1" displayUnit="l/min">
                       <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                       <Info min="0" flag="122" seq="119" ref="0" bb="32" group="58" />
                     </Parameter>
-                    <Parameter id="B-iQo1Z2_0uLbBVmKSAzDg" name="Blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_mucosa" isDefault="1" displayUnit="l/min">
+                    <Parameter id="4L8kXKEZAECPGEJOWLCEBQ" name="Volume (endothelium)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="VascularEndoVolume.VOLUME_VascularEndo_coldesc" isDefault="1" displayUnit="l">
+                      <Info min="0" flag="62" seq="119" ref="0" bb="32" group="127" />
+                    </Parameter>
+                    <Parameter id="AyzBbcxO2kOTcijWW4q7vw" name="Blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_mucosa" isDefault="1" displayUnit="l/min">
                       <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
                       <Info min="0" flag="122" seq="308" ref="0" bb="32" group="5" />
                     </Parameter>
-                    <Parameter id="eRHCIV67YU2pbkLBKwJTpg" name="Fraction intracellular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_f_cell" isDefault="1">
+                    <Parameter id="wTWacj6bM0m9YKHUhdYHGQ" name="Fraction intracellular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_f_cell" isDefault="1">
                       <Info min="0" max="1" flag="62" seq="358" ref="0" bb="32" group="64" />
                     </Parameter>
-                    <Parameter id="JMx_kzLA0U6OJW3ZDNSMtQ" name="Density (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
+                    <Parameter id="j02MJM7Hxk-sQYs0uM1YBw" name="Density (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
                       <Info min="0" flag="38" seq="1" ref="0" bb="32" group="21" />
                     </Parameter>
-                    <Parameter id="O-oN5uDOo0Oj65O0nsvmcw" name="Fraction of regional blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.24">
-                      <Info min="0" flag="54" seq="1" ref="0" bb="32" group="39" />
+                    <Parameter id="KoJhSnDRSEeJzbTByIqxbA" name="Fraction mucosa" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.14">
+                      <Info min="0" max="1" flag="122" seq="1" ref="0" bb="32" group="40" />
                     </Parameter>
-                    <Parameter id="wi5oNcxz4EiX9YQwUY0ZzA" name="Fraction mucosa" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.14">
-                      <Info min="0" max="1" flag="58" seq="1" ref="0" bb="32" group="40" />
+                    <Parameter id="YbyXhVH4TEa4Rq3_U_A33A" name="Fraction of regional blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.24">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="32" group="39" />
                     </Parameter>
-                    <Parameter id="ynYsrZ4VI0ayHqP7IuHrwQ" name="Fraction of blood for sampling" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                    <Parameter id="nJEy34B6KUOIBXGHMweJxQ" name="Fraction of blood for sampling" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
                       <Info min="0" max="1" flag="54" seq="1" ref="0" bb="32" group="94" />
                     </Parameter>
-                    <Parameter id="rnqp71794kqIXNd_HOt-Yw" name="Radius (small pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="4.5E-08" displayUnit="µm">
+                    <Parameter id="Rb-_IH5R9kW80iWZzBcrqA" name="Flow fraction via large pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.05">
                       <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-                      <Info min="0" flag="122" seq="119" ref="0" bb="32" group="99" />
+                      <Info min="0" max="1" flag="122" seq="119" ref="0" bb="32" group="114" />
                     </Parameter>
-                    <Parameter id="YacPdUERQk2DipsycWmlAQ" name="Radius (large pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.5E-07" displayUnit="µm">
+                    <Parameter id="1NXGhI5080WywIy0La5Q8w" name="Hydraulic conductivity" icon="Parameter" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.86944444444444E-10" displayUnit="ml/min/N">
                       <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-                      <Info min="0" flag="122" seq="119" ref="0" bb="32" group="55" />
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-                            <Parameter id="0Yrogm5UK0CNw0K_irB2Fw" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                            <Parameter id="w5bBohXGt0O6YlLYleCK2A" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                             </Parameter>
-                            <Parameter id="7kBaFIo79UioBYfhtKMeEw" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                            <Parameter id="LiNKNM2gK0OK6fhWp8l9YA" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" isDefault="1">
+                              <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                            </Parameter>
+                            <Parameter id="TAAtISicnEax7ZiedjIG6w" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
                               <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                             </Parameter>
                           </Children>
                         </Container>
                       </Children>
                     </Container>
-                    <Container id="nnvbzvW5h0yCFsMRXX-tug" name="Interstitial" mode="Physical" containerType="Compartment">
+                    <Container id="VytvFP3rgkOt4KuoYbrDmQ" name="Interstitial" mode="Physical" containerType="Compartment">
                       <Tags>
                         <Tag value="ColonDescendens" />
                         <Tag value="LargeIntestineSegment" />
                         <Tag value="Mucosa" />
                       </Tags>
                       <Children>
-                        <Parameter id="YqNkN-XyX0KcS-UNKn-ZVA" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                        <Parameter id="6bzzDJdr2kSYQWNnVbI_Pw" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
                           <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                         </Parameter>
-                        <Parameter id="a3j1S8CfzUW7Pz64q2EVvw" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" isDefault="1" displayUnit="l">
+                        <Parameter id="EPnwvUKn20iyefCgnYCNYQ" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" isDefault="1" displayUnit="l">
                           <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                           <Info min="0" flag="62" seq="119" ref="0" bb="2" group="124" />
                         </Parameter>
-                        <Parameter id="-qxCtjae_E2ZoGveTBG_tA" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_pH_INT" isDefault="1">
+                        <Parameter id="oQVAk57hjkm3WTyQQgQEhA" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_pH_INT" isDefault="1">
                           <Tags>
                             <Tag value="ColonDescendens" />
                             <Tag value="LargeIntestineSegment" />
@@ -10064,22 +10123,22 @@
                           </Tags>
                           <Info min="0" max="14" flag="122" seq="359" ref="0" bb="32" group="84" />
                         </Parameter>
-                        <Container id="w6dFHVabbEKD7DBPopY2sQ" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                        <Container id="zzO733NuU0O1nLTTbNpHtg" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                           <Children>
-                            <Parameter id="4FSGZHh8K0SajQKET86V0g" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_coldesc" isDefault="1">
+                            <Parameter id="rdYpNISDgkO8cHkvV22ADw" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                              <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                            </Parameter>
+                            <Parameter id="BWbeULvVzEqKGa0d_67i8A" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_coldesc" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                             </Parameter>
-                            <Parameter id="3TjXmYo3I0yYhOITfGoKUg" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                            <Parameter id="m-z778HyvUSeV_JuX_-l-w" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
                               <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                             </Parameter>
-                            <Parameter id="Mg1_x5WME0SAPYjhUWzrVg" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
-                              <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
-                            </Parameter>
                           </Children>
                         </Container>
                       </Children>
                     </Container>
-                    <Container id="iaAT-1dG0USXIQUM5EweVw" name="Intracellular" mode="Physical" containerType="Compartment">
+                    <Container id="lB3zaDNmVkWiBvM88nUHOw" name="Intracellular" mode="Physical" containerType="Compartment">
                       <Tags>
                         <Tag value="ColonDescendens" />
                         <Tag value="IntestinalSecretionSource" />
@@ -10087,14 +10146,14 @@
                         <Tag value="Mucosa" />
                       </Tags>
                       <Children>
-                        <Parameter id="Jbnme28NXEm85lDBBix6QQ" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" isDefault="1" displayUnit="l">
+                        <Parameter id="UrrMAknR8UKw5HprRtiwFA" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" isDefault="1" displayUnit="l">
                           <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                         </Parameter>
-                        <Parameter id="I_BBnBiJ202uhJZuNV3t2g" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" isDefault="1" displayUnit="l">
+                        <Parameter id="znzwXAk_jk6ZT5DPrfxoJg" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" isDefault="1" displayUnit="l">
                           <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                           <Info min="0" flag="62" seq="119" ref="0" bb="2" group="125" />
                         </Parameter>
-                        <Parameter id="p2HihOaxfUW7NBAMMkVhZQ" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.3">
+                        <Parameter id="vUlEDPriq0K0niGULDMg1A" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.3">
                           <Tags>
                             <Tag value="ColonDescendens" />
                             <Tag value="IntestinalSecretionSource" />
@@ -10104,226 +10163,226 @@
                           <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
                           <Info min="0" max="14" flag="122" seq="359" ref="0" bb="32" group="83" />
                         </Parameter>
-                        <Container id="GzS3B_RAx0KpajsxZfLCkA" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                        <Container id="YGpLkBVM-USJ-uUIWMZ0HQ" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                           <Children>
-                            <Parameter id="Ny16j829T02CG5OHQDa0eA" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                            <Parameter id="kLvtiQFGUU6WpJoFeRoxKA" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                             </Parameter>
-                            <Parameter id="pe7LfxEPbUq-qIPyO5HbjA" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_coldesc" isDefault="1">
+                            <Parameter id="mlJfcc5AVUKHZq_QLmuQ8Q" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_coldesc" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                             </Parameter>
-                            <Parameter id="J8EucddkvkmvR-VbET2WgQ" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                            <Parameter id="RCPV6R82ikqKmRAsbcGTZg" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
                               <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                             </Parameter>
                           </Children>
                         </Container>
                       </Children>
                     </Container>
-                    <Container id="ddLyfcNh4kCVNT-WKdp73Q" name="MoleculeProperties" mode="Logical" containerType="Molecule" />
+                    <Container id="3I6_PLSl7EuXQhH6ugwGtw" name="MoleculeProperties" mode="Logical" containerType="Molecule" />
                   </Children>
                 </Container>
-                <Container id="HlLMHT6KC0iMG_Mk0T-JNQ" name="ColonSigmoid" mode="Logical" containerType="Compartment">
+                <Container id="qcb7BkUb3kWw61raLeB0ag" name="ColonSigmoid" mode="Logical" containerType="Compartment">
                   <Children>
-                    <Parameter id="KgIxPcGdKkGwMybYXHqlqw" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
+                    <Parameter id="drE_n4tik0ypvG7K_MVssg" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
                       <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
                     </Parameter>
-                    <Parameter id="OoLUEFuJ9EuyhyY0rKnl0g" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="MucosaVolume.VOLUME_MucosaColonSigmoid" isDefault="1" displayUnit="l">
+                    <Parameter id="a1yjf7-k4kGcg0K7rpzF0g" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="MucosaVolume.VOLUME_MucosaColonSigmoid" isDefault="1" displayUnit="l">
                       <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
                       <Info min="0" flag="122" seq="29" ref="0" bb="32" group="65" />
                     </Parameter>
-                    <Parameter id="j2G027sewUeZckpnJOdonw" name="Volume (endothelium)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="VascularEndoVolume.VOLUME_VascularEndo_colsigm" isDefault="1" displayUnit="l">
-                      <Info min="0" flag="62" seq="120" ref="0" bb="32" group="127" />
+                    <Parameter id="hoERAWQodUiybP4jnyzw7g" name="Fluid recirculation flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_J_iso_Mucosa" isDefault="1" displayUnit="l/min">
+                      <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                      <Info min="0" flag="122" seq="120" ref="0" bb="32" group="27" />
                     </Parameter>
-                    <Parameter id="vir-QgR00kC9_cDIPIkwtw" name="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_lymph_mucosa" isDefault="1" displayUnit="l/min">
+                    <Parameter id="er4IC6g_VkmRa_rjKA2W-g" name="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_lymph_mucosa" isDefault="1" displayUnit="l/min">
                       <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                       <Info min="0" flag="122" seq="120" ref="0" bb="32" group="58" />
                     </Parameter>
-                    <Parameter id="wZdYx91ZR0e86vdQHmhFUw" name="Fluid recirculation flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_J_iso_Mucosa" isDefault="1" displayUnit="l/min">
-                      <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-                      <Info min="0" flag="122" seq="120" ref="0" bb="32" group="27" />
+                    <Parameter id="-S19mVGRY0GJBjmqHubzAA" name="Volume (endothelium)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="VascularEndoVolume.VOLUME_VascularEndo_colsigm" isDefault="1" displayUnit="l">
+                      <Info min="0" flag="62" seq="120" ref="0" bb="32" group="127" />
                     </Parameter>
-                    <Parameter id="cRGLy4MO1EKuJjLWHd3U8w" name="Blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_mucosa" isDefault="1" displayUnit="l/min">
+                    <Parameter id="Sb4xyF4ZYkKHnO1jl-2SNw" name="Blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_mucosa" isDefault="1" displayUnit="l/min">
                       <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
                       <Info min="0" flag="122" seq="309" ref="0" bb="32" group="5" />
                     </Parameter>
-                    <Parameter id="9O3WUv71406zYxnjY6T1Og" name="Fraction intracellular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_f_cell" isDefault="1">
+                    <Parameter id="ghHFFPy1W0G2LR73t7VBoA" name="Fraction intracellular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_f_cell" isDefault="1">
                       <Info min="0" max="1" flag="62" seq="361" ref="0" bb="32" group="64" />
                     </Parameter>
-                    <Parameter id="nn8tB2bqK0mLgudt_ZViHg" name="Density (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
+                    <Parameter id="3NIdzUGSgEu18wtL6ggtxQ" name="Density (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
                       <Info min="0" flag="38" seq="1" ref="0" bb="32" group="21" />
                     </Parameter>
-                    <Parameter id="IUJ3Q5t_eU2q4V5AJmlWAw" name="Fraction of regional blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.135">
-                      <Info min="0" flag="54" seq="1" ref="0" bb="32" group="39" />
+                    <Parameter id="OIzVvUMQekqqFv5EIyoQcg" name="Fraction mucosa" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.3">
+                      <Info min="0" max="1" flag="122" seq="1" ref="0" bb="32" group="40" />
                     </Parameter>
-                    <Parameter id="IUq35TCjoEaFNQwgIj4vxA" name="Fraction mucosa" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.3">
-                      <Info min="0" max="1" flag="58" seq="1" ref="0" bb="32" group="40" />
+                    <Parameter id="rpY0YcWM7kuCgpw02ckmFw" name="Fraction of regional blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.135">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="32" group="39" />
                     </Parameter>
-                    <Parameter id="XKPy3l8ZJUC4exKYeSI8EQ" name="Fraction of blood for sampling" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                    <Parameter id="zrd13CtbfU-GMY2f4pngug" name="Fraction of blood for sampling" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
                       <Info min="0" max="1" flag="54" seq="1" ref="0" bb="32" group="94" />
                     </Parameter>
-                    <Parameter id="CDh1biEaREyYo4dY35lVbQ" name="Radius (large pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.5E-07" displayUnit="µm">
+                    <Parameter id="6J77bd6BZ028NZ-BxTRNNg" name="Flow fraction via large pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.05">
                       <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-                      <Info min="0" flag="122" seq="120" ref="0" bb="32" group="55" />
+                      <Info min="0" max="1" flag="122" seq="120" ref="0" bb="32" group="114" />
                     </Parameter>
-                    <Parameter id="SRxu45nkt06MU6CKHIVovA" name="Hydraulic conductivity" icon="Parameter" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.86944444444444E-10" displayUnit="ml/min/N">
+                    <Parameter id="JpyBKSsp9k6kJONEGPHY5g" name="Hydraulic conductivity" icon="Parameter" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.86944444444444E-10" displayUnit="ml/min/N">
                       <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                       <Info min="0" flag="122" seq="120" ref="0" bb="32" group="115" />
                     </Parameter>
-                    <Parameter id="IPVzuwI7i0eEeMdqDrVimA" name="Radius (small pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="4.5E-08" displayUnit="µm">
+                    <Parameter id="CWMuUZjl70izS46gW75HFA" name="Radius (large pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.5E-07" displayUnit="µm">
                       <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-                      <Info min="0" flag="122" seq="120" ref="0" bb="32" group="99" />
+                      <Info min="0" flag="122" seq="120" ref="0" bb="32" group="55" />
                     </Parameter>
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+                            <Parameter id="XSseaSxYZ0atTR_q3w-aNw" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
                               <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                             </Parameter>
                           </Children>
                         </Container>
                       </Children>
                     </Container>
-                    <Container id="yv_YyAZA6kGkZtTW9kyhcw" name="Interstitial" mode="Physical" containerType="Compartment">
+                    <Container id="UQxGm737EEy5IT7mHMQoGQ" name="Interstitial" mode="Physical" containerType="Compartment">
                       <Tags>
                         <Tag value="ColonSigmoid" />
                         <Tag value="LargeIntestineSegment" />
                         <Tag value="Mucosa" />
                       </Tags>
                       <Children>
-                        <Parameter id="tcyMOTh9fk6y5kmdgp6Flw" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                        <Parameter id="Ul16Z9Wjf0mDVLGApMEbhg" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
                           <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                         </Parameter>
-                        <Parameter id="6ysKrQt2VEeMmskZle3DMg" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" isDefault="1" displayUnit="l">
+                        <Parameter id="vnQ586cgo0q2gutYHvnENw" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" isDefault="1" displayUnit="l">
                           <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                           <Info min="0" flag="62" seq="120" ref="0" bb="2" group="124" />
                         </Parameter>
-                        <Parameter id="iqxg6-xhBUKj5xuZwwRN7g" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_pH_INT" isDefault="1">
+                        <Parameter id="YmMPvsieXUWSZ66WAHHYwA" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_pH_INT" isDefault="1">
                           <Tags>
                             <Tag value="ColonSigmoid" />
                             <Tag value="LargeIntestineSegment" />
@@ -10331,22 +10390,22 @@
                           </Tags>
                           <Info min="0" max="14" flag="122" seq="362" ref="0" bb="32" group="84" />
                         </Parameter>
-                        <Container id="ZWagXoGe0USSqXihT4UiaA" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                        <Container id="WOaldIb3LUuCwV9DNo-Wzw" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                           <Children>
-                            <Parameter id="pMrHYAESt0yat88esgHfLg" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                            <Parameter id="xI3eQ9OVEU-K9UBcBpo0dA" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                             </Parameter>
-                            <Parameter id="mjHebV9MgEq3hQ-uUb5p6A" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_colsigm" isDefault="1">
+                            <Parameter id="iWEqGzx7gUCXCHGk1N1CkQ" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_colsigm" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                             </Parameter>
-                            <Parameter id="Yuril2AMsEeq-yu18meLuw" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                            <Parameter id="8MOIh4JWGE-td_sRnbuy_w" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
                               <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                             </Parameter>
                           </Children>
                         </Container>
                       </Children>
                     </Container>
-                    <Container id="-UolCvDsZkqBk6uvEQwkyg" name="Intracellular" mode="Physical" containerType="Compartment">
+                    <Container id="tN9zkiBQG0CU40pBquto3w" name="Intracellular" mode="Physical" containerType="Compartment">
                       <Tags>
                         <Tag value="ColonSigmoid" />
                         <Tag value="IntestinalSecretionSource" />
@@ -10354,14 +10413,14 @@
                         <Tag value="Mucosa" />
                       </Tags>
                       <Children>
-                        <Parameter id="Pv0KsE8Fs06tbn4eQpBP_A" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" isDefault="1" displayUnit="l">
+                        <Parameter id="NpSZoFkfEUq-VS9A9RCzfw" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" isDefault="1" displayUnit="l">
                           <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                         </Parameter>
-                        <Parameter id="CABHs1qAvEi-wiqP9SC40Q" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" isDefault="1" displayUnit="l">
+                        <Parameter id="xWYlRIRWik6stXIvQ_9QpQ" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" isDefault="1" displayUnit="l">
                           <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                           <Info min="0" flag="62" seq="120" ref="0" bb="2" group="125" />
                         </Parameter>
-                        <Parameter id="xJTROEOKUEGdCHre2womKQ" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.3">
+                        <Parameter id="a2suIlj3BEm3SMnVuDHNmw" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.3">
                           <Tags>
                             <Tag value="ColonSigmoid" />
                             <Tag value="IntestinalSecretionSource" />
@@ -10371,226 +10430,226 @@
                           <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
                           <Info min="0" max="14" flag="122" seq="362" ref="0" bb="32" group="83" />
                         </Parameter>
-                        <Container id="L39xd3RwAkGr3_ubaGCU9A" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                        <Container id="x3N6PFpHiU6NcmkSNNXFXw" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                           <Children>
-                            <Parameter id="X7qwsdgpNUWRiXS1SiXHGQ" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                            <Parameter id="_o_fNU4XykWi9RFG2OHXWw" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                             </Parameter>
-                            <Parameter id="0pdgLhXY_UeQE5bFlXP3qw" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_colsigm" isDefault="1">
+                            <Parameter id="Wfc7FB_le0e5kNUn2lCixA" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_colsigm" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                             </Parameter>
-                            <Parameter id="JPL3myMsE0yO16qV-KioQA" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                            <Parameter id="5a4W-7xdjEixSkRzB1dGvA" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
                               <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                             </Parameter>
                           </Children>
                         </Container>
                       </Children>
                     </Container>
-                    <Container id="VEF8rm-skEKzhBZlA31QXw" name="MoleculeProperties" mode="Logical" containerType="Molecule" />
+                    <Container id="8YnSW2W5UEGHvN2-Osm-tw" name="MoleculeProperties" mode="Logical" containerType="Molecule" />
                   </Children>
                 </Container>
-                <Container id="Cr7_NMuOjkSH0YoxdLkJQQ" name="Rectum" mode="Logical" containerType="Compartment">
+                <Container id="bw16q3PDEkODoYU9jRtOzg" name="Rectum" mode="Logical" containerType="Compartment">
                   <Children>
-                    <Parameter id="E9yyrcUO6kSMseuCoIr5Lw" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
+                    <Parameter id="eYcT1m5110KGwyKYlHLUEA" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
                       <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
                     </Parameter>
-                    <Parameter id="hkJXbfjuGUKjvD-nF4qooA" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="MucosaVolume.VOLUME_MucosaRectum" isDefault="1" displayUnit="l">
+                    <Parameter id="8hlMX_bI7E-HusECvBRY7Q" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="MucosaVolume.VOLUME_MucosaRectum" isDefault="1" displayUnit="l">
                       <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
                       <Info min="0" flag="122" seq="30" ref="0" bb="32" group="65" />
                     </Parameter>
-                    <Parameter id="fckbUcvSpUeNIviPDeH3qA" name="Volume (endothelium)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="VascularEndoVolume.VOLUME_VascularEndo_rect" isDefault="1" displayUnit="l">
-                      <Info min="0" flag="62" seq="121" ref="0" bb="32" group="127" />
+                    <Parameter id="Q0lfpcjPsEK4QwvcGhD8fw" name="Fluid recirculation flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_J_iso_Mucosa" isDefault="1" displayUnit="l/min">
+                      <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                      <Info min="0" flag="122" seq="121" ref="0" bb="32" group="27" />
                     </Parameter>
-                    <Parameter id="v_THer-o1k66wNf6NFYcHw" name="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_lymph_mucosa" isDefault="1" displayUnit="l/min">
+                    <Parameter id="s6J6LwI5rUmFffk_8nXPYA" name="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_lymph_mucosa" isDefault="1" displayUnit="l/min">
                       <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                       <Info min="0" flag="122" seq="121" ref="0" bb="32" group="58" />
                     </Parameter>
-                    <Parameter id="2JHafw-X5EGfvL_un5nsQA" name="Fluid recirculation flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_J_iso_Mucosa" isDefault="1" displayUnit="l/min">
-                      <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-                      <Info min="0" flag="122" seq="121" ref="0" bb="32" group="27" />
+                    <Parameter id="U9FPqgALd0ieu8Sq6EMcxA" name="Volume (endothelium)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="VascularEndoVolume.VOLUME_VascularEndo_rect" isDefault="1" displayUnit="l">
+                      <Info min="0" flag="62" seq="121" ref="0" bb="32" group="127" />
                     </Parameter>
-                    <Parameter id="Gs-CvEF2NUuAIIouEgkQnw" name="Blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_mucosa" isDefault="1" displayUnit="l/min">
+                    <Parameter id="FzXhy_8hukOPQlEXnU_CDg" name="Blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_mucosa" isDefault="1" displayUnit="l/min">
                       <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
                       <Info min="0" flag="122" seq="310" ref="0" bb="32" group="5" />
                     </Parameter>
-                    <Parameter id="MeJGN8cU1Uy2TTYVCR_GnA" name="Fraction intracellular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_f_cell" isDefault="1">
+                    <Parameter id="wLk4UpjGsUqvwQQl0BuFJA" name="Fraction intracellular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_f_cell" isDefault="1">
                       <Info min="0" max="1" flag="46" seq="364" ref="0" bb="32" group="64" />
                     </Parameter>
-                    <Parameter id="0fYHNhwD2E-XryRtru9pFg" name="Density (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
+                    <Parameter id="g5bxBYw3v06oHX5xZUihnw" name="Density (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
                       <Info min="0" flag="38" seq="1" ref="0" bb="32" group="21" />
                     </Parameter>
-                    <Parameter id="RC8zLtkzmUO-No_xZ5NzGA" name="Fraction of regional blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.055">
-                      <Info min="0" flag="54" seq="1" ref="0" bb="32" group="39" />
+                    <Parameter id="t76IXru2BkOkkHAska3JHA" name="Fraction mucosa" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.3">
+                      <Info min="0" max="1" flag="122" seq="1" ref="0" bb="32" group="40" />
                     </Parameter>
-                    <Parameter id="3C5XvZAAnEGxTb8LR-iEzA" name="Fraction mucosa" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.3">
-                      <Info min="0" max="1" flag="58" seq="1" ref="0" bb="32" group="40" />
+                    <Parameter id="QCEMI__Dc0WCM9MPdUKJcA" name="Fraction of regional blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.055">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="32" group="39" />
                     </Parameter>
-                    <Parameter id="qHS_0EwzBU2Dj7YgaENt_Q" name="Fraction of blood for sampling" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                    <Parameter id="9ldRTVd1XUqhvs3-Fm24nA" name="Fraction of blood for sampling" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
                       <Info min="0" max="1" flag="54" seq="1" ref="0" bb="32" group="94" />
                     </Parameter>
-                    <Parameter id="1j_q4FLOmE-Y9ws33DlvVg" name="Radius (small pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="4.5E-08" displayUnit="µm">
+                    <Parameter id="niLDAB9lVkOmKw5rOz3gSw" name="Flow fraction via large pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.05">
                       <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
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+                      <Info min="0" max="1" flag="122" seq="121" ref="0" bb="32" group="114" />
                     </Parameter>
-                    <Parameter id="JVlBwSX-x0CliIJeGS6k2A" name="Radius (large pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.5E-07" displayUnit="µm">
+                    <Parameter id="JIUd_pH-DkuN7Wlvayjhaw" name="Hydraulic conductivity" icon="Parameter" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.86944444444444E-10" displayUnit="ml/min/N">
                       <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-                      <Info min="0" flag="122" seq="121" ref="0" bb="32" group="55" />
+                      <Info min="0" flag="122" seq="121" ref="0" bb="32" group="115" />
                     </Parameter>
-                    <Parameter id="jiPvBd_CJUyL1d35qLEXWA" name="Hydraulic conductivity" icon="Parameter" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.86944444444444E-10" displayUnit="ml/min/N">
+                    <Parameter id="8Inay07RWkOFlf6Zrws0_Q" name="Radius (large pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.5E-07" displayUnit="µm">
                       <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-                      <Info min="0" flag="122" seq="121" ref="0" bb="32" group="115" />
+                      <Info min="0" flag="122" seq="121" ref="0" bb="32" group="55" />
                     </Parameter>
-                    <Parameter id="E4atRRl3W0K3KlV6D-8Dgw" name="Flow fraction via large pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.05">
+                    <Parameter id="pFGsFn_l9EWaaJrKx2AO0Q" name="Radius (small pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="4.5E-08" displayUnit="µm">
                       <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-                      <Info min="0" max="1" flag="122" seq="121" ref="0" bb="32" group="114" />
+                      <Info min="0" flag="122" seq="121" ref="0" bb="32" group="99" />
+                    </Parameter>
+                    <Parameter id="Ts6q6w7s3UGCEQ5Snu8j4Q" name="Fraction vascular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.08">
+                      <Info min="0" max="1" flag="62" seq="363" ref="0" bb="32" group="64" />
                     </Parameter>
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-                    <Container id="K1OeylTfR0SqocJXnLob3g" name="Interstitial" mode="Physical" containerType="Compartment">
+                    <Container id="Yx0Z8ur6JU6CM5_rwqvx4g" name="Interstitial" mode="Physical" containerType="Compartment">
                       <Tags>
                         <Tag value="LargeIntestineSegment" />
                         <Tag value="Mucosa" />
                         <Tag value="Rectum" />
                       </Tags>
                       <Children>
-                        <Parameter id="8D3l_E_wK0eH5Z3TujT-9w" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                        <Parameter id="TTzW7eGjSk2S3fGKaynT6Q" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
                           <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                         </Parameter>
-                        <Parameter id="BrqVH33M80yglbxqkyXlnQ" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" isDefault="1" displayUnit="l">
+                        <Parameter id="5PkGYfrnW0-xftBYd1DFMA" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" isDefault="1" displayUnit="l">
                           <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                           <Info min="0" flag="62" seq="121" ref="0" bb="2" group="124" />
                         </Parameter>
-                        <Parameter id="VwTMIJFCXUONrFE1zOc0dg" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_pH_INT" isDefault="1">
+                        <Parameter id="m50BJ6F5b0SmmHNXuM3L6g" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_pH_INT" isDefault="1">
                           <Tags>
                             <Tag value="LargeIntestineSegment" />
                             <Tag value="Mucosa" />
@@ -10598,22 +10657,22 @@
                           </Tags>
                           <Info min="0" max="14" flag="122" seq="365" ref="0" bb="32" group="84" />
                         </Parameter>
-                        <Container id="19_XUuXQFUa-yG4MbIPGAw" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                        <Container id="28Nj-__KY0SlOGrbdn63_w" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                           <Children>
-                            <Parameter id="ghw_xvonn0yi0sFabAGG9w" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_rect" isDefault="1">
-                              <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
-                            </Parameter>
-                            <Parameter id="Oq1Y5oXqd0CbRkmXROuJPg" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                            <Parameter id="4jTvsyjE0U-7IriMB1Otsg" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                             </Parameter>
-                            <Parameter id="QH3LrajB2kqhyvKgHcfncA" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                            <Parameter id="CQtJ5hYLO0WsTwQrMhLRyg" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_rect" isDefault="1">
+                              <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                            </Parameter>
+                            <Parameter id="bLfNoyvHGUyScxwjsS4Dlw" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
                               <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                             </Parameter>
                           </Children>
                         </Container>
                       </Children>
                     </Container>
-                    <Container id="oTMjp1TYnUWpLJraDSSQMA" name="Intracellular" mode="Physical" containerType="Compartment">
+                    <Container id="iIAVNSjiW0S2nzttLSTPAw" name="Intracellular" mode="Physical" containerType="Compartment">
                       <Tags>
                         <Tag value="IntestinalSecretionSource" />
                         <Tag value="LargeIntestineSegment" />
@@ -10621,14 +10680,14 @@
                         <Tag value="Rectum" />
                       </Tags>
                       <Children>
-                        <Parameter id="BQ9yQj40q0aOyDfUPy5EYQ" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" isDefault="1" displayUnit="l">
+                        <Parameter id="OPC1ry6_EEygzRjahaHslQ" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" isDefault="1" displayUnit="l">
                           <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                         </Parameter>
-                        <Parameter id="jiHNZ0OGmkC0UGOrZwBVmw" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" isDefault="1" displayUnit="l">
+                        <Parameter id="S22oKklkqEONQBhxMQLBLQ" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" isDefault="1" displayUnit="l">
                           <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                           <Info min="0" flag="62" seq="121" ref="0" bb="2" group="125" />
                         </Parameter>
-                        <Parameter id="_sHPtkibWE2dEFtVB9C13w" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.3">
+                        <Parameter id="KemIisjL40WzU4JqKa1FYQ" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.3">
                           <Tags>
                             <Tag value="IntestinalSecretionSource" />
                             <Tag value="LargeIntestineSegment" />
@@ -10638,559 +10697,561 @@
                           <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
                           <Info min="0" max="14" flag="122" seq="365" ref="0" bb="32" group="83" />
                         </Parameter>
-                        <Container id="LLhL3aiHiEeaDallRsWWCA" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                        <Container id="zoqVkespWkWkTYKyPorohw" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                           <Children>
-                            <Parameter id="WeWbmOq6UkiIVbPuhLLn6A" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                            <Parameter id="J3imNEutdEydcqhSm1qS9w" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                             </Parameter>
-                            <Parameter id="Q_4A5vT4gUeqa5X9UOdKpw" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_rect" isDefault="1">
+                            <Parameter id="OZGuXsKzo0eP-blG-ME29A" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_rect" isDefault="1">
                               <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                             </Parameter>
-                            <Parameter id="vjy5elj1lUGWOMAYr0SYVg" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
+                            <Parameter id="YkqXUV9siEa75qnBh-wiyg" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Intestine" isDefault="1" displayUnit="min">
                               <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                             </Parameter>
                           </Children>
                         </Container>
                       </Children>
                     </Container>
-                    <Container id="XEQ-GcoBn0SIF00hRmKl-Q" name="MoleculeProperties" mode="Logical" containerType="Molecule" />
+                    <Container id="kHLfoxX6b0OFowGLXm2A8A" name="MoleculeProperties" mode="Logical" containerType="Molecule" />
                   </Children>
                 </Container>
               </Children>
             </Container>
           </Children>
         </Container>
-        <Container id="BiPTZMlzSUS20eFDsyqyzw" name="Liver" mode="Logical" containerType="Organ">
+        <Container id="0GN2Z6VOaUak_OuQAcv-oA" name="Liver" mode="Logical" containerType="Organ">
           <Children>
-            <Parameter id="uYo55Z_85kWHUAp6MFXPeg" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
+            <Parameter id="W5C1P9awQ063M7a483xjMA" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
               <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
             </Parameter>
-            <Parameter id="NrM9nxvxuUqGLFHrTbgU0g" name="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Lymph_flow_rate" isDefault="1" displayUnit="l/min">
+            <Parameter id="pPPZThQdEEm8AZfVK6cDOg" name="Fluid recirculation flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate" isDefault="1" displayUnit="l/min">
+              <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+              <Info min="0" flag="122" seq="17" ref="0" bb="32" group="27" />
+            </Parameter>
+            <Parameter id="lgr8zHXXAkmyL-xsqXTU5w" name="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Lymph_flow_rate" isDefault="1" displayUnit="l/min">
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
               <Info min="0" flag="122" seq="17" ref="0" bb="32" group="58" />
             </Parameter>
-            <Parameter id="5hDsqSTFT06eeCtPXkk-9A" name="Volume (endothelium)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="VascularEndoVolume.VOLUME_VascularEndo_liv" isDefault="1" displayUnit="l">
+            <Parameter id="m3cej9fK0EyVeadFbtjaDg" name="Volume (endothelium)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="VascularEndoVolume.VOLUME_VascularEndo_liv" isDefault="1" displayUnit="l">
               <Info min="0" flag="62" seq="17" ref="0" bb="32" group="127" />
             </Parameter>
-            <Parameter id="AuE92OdLTU6eHwswitNgYA" name="Fluid recirculation flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate" isDefault="1" displayUnit="l/min">
-              <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-              <Info min="0" flag="122" seq="17" ref="0" bb="32" group="27" />
+            <Parameter id="JJR_QVikQ0iGnkVxfaNvfg" name="Fraction intracellular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_f_cell" isDefault="1">
+              <Info min="0" max="1" flag="62" seq="54" ref="0" bb="32" group="64" />
             </Parameter>
-            <Parameter id="NPV8Lg1qNkqXTVqpeoph2A" name="Is liver zonated" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0">
+            <Parameter id="Pkjkie9SZ06FlLaEySZFUQ" name="Is liver zonated" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0">
               <Info min="0" max="1" flag="58" seq="54" ref="0" bb="32" group="149" />
             </Parameter>
-            <Parameter id="ny2Kd3eX60eTeNBiKII7Og" name="Fraction intracellular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_f_cell" isDefault="1">
-              <Info min="0" max="1" flag="62" seq="54" ref="0" bb="32" group="64" />
-            </Parameter>
-            <Parameter id="w6SUvHgvUUeKmBXzD6GEcQ" name="Fraction of periportal zone" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5" displayUnit="%">
+            <Parameter id="j2416eaVm0KJxXRHKYTsxw" name="Fraction of periportal zone" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5" displayUnit="%">
               <Info min="0" max="1" flag="74" seq="55" ref="0" bb="32" group="149" />
             </Parameter>
-            <Parameter id="vcHlV5tQnkSPZFQvr4Omrw" name="Blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_from_Qspec" isDefault="1" displayUnit="l/min">
-              <ValueOrigin id="48" description="TODO: Absolute from specific calculation" />
+            <Parameter id="b0hUbjCreEi79HREMYE6Eg" name="Blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_from_Qspec" isDefault="1" displayUnit="l/min">
+              <ValueOrigin id="48" source="Other" description="Absolute value = specific value (i.e. value normalized to the volume of the organ) multiplied by the organ volume" />
               <Info min="0" flag="62" seq="142" ref="0" bb="32" group="5" />
             </Parameter>
-            <Parameter id="I5wlGMcTikWL9UUuCefs9Q" name="Fluid recirculation flow proportionality factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.96">
+            <Parameter id="oJPTwb00k0uuo-pdC8JObg" name="Density (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
+              <Info min="0" flag="38" seq="1" ref="0" bb="32" group="21" />
+            </Parameter>
+            <Parameter id="z-g0UQwsGkynlI_Bmbj1bQ" name="EHC continuous fraction" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0">
+              <Info min="0" max="1" flag="122" seq="1" ref="0" bb="32" group="128" />
+            </Parameter>
+            <Parameter id="yCwkjGVMu02JDIYqK-wGmQ" name="Fluid recirculation flow proportionality factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.96">
               <Info min="0" flag="54" seq="1" ref="0" bb="32" group="27" />
             </Parameter>
-            <Parameter id="amn_zkX3vUacoc7kp_vMcQ" name="Lymph flow proportionality factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0199">
+            <Parameter id="U4JFe92e50WcOkLbbQNsEg" name="Lymph flow proportionality factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0199">
               <Info min="0" flag="54" seq="1" ref="0" bb="32" group="58" />
             </Parameter>
-            <Parameter id="qw5lybAbF0qlUF8ZTtuTwg" name="Organ volume mouse" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0013" displayUnit="l">
+            <Parameter id="tXZOmI9LmEeWSTo0WfIZSw" name="Organ volume mouse" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0013" displayUnit="l">
               <Info min="0" flag="54" seq="1" ref="0" bb="32" group="65" />
             </Parameter>
-            <Parameter id="s7XKL6jgeUKPPxLo0fX9xA" name="EHC continuous fraction" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0">
-              <Info min="0" max="1" flag="122" seq="1" ref="0" bb="32" group="128" />
-            </Parameter>
-            <Parameter id="lb63-hAU90uN_JTp8QvLwA" name="Density (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
-              <Info min="0" flag="38" seq="1" ref="0" bb="32" group="21" />
-            </Parameter>
-            <Parameter id="yrUFc-vjM0euTtfrf-z_dw" name="Allometric scale factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.75">
+            <Parameter id="R4K8EDCVDUCTksxoiwwhGg" name="Allometric scale factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.75">
               <Info min="0.75" max="0.75" flag="54" seq="1" ref="0" bb="32" group="2" />
             </Parameter>
-            <Parameter id="B0t6AobMUEexdmZ8avG44A" name="Fraction of blood for sampling" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+            <Parameter id="baCovFPmLEOyrhcT2cy8Jg" name="Fraction of blood for sampling" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
               <Info min="0" max="1" flag="54" seq="1" ref="0" bb="32" group="94" />
             </Parameter>
-            <Parameter id="ST9ntXcifk-FqRxFJDhppQ" name="Radius (small pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="9E-08" displayUnit="µm">
+            <Parameter id="kBLAToLHv0mBtLuIH6cbKg" name="Flow fraction via large pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.8">
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-              <Info min="0" flag="122" seq="17" ref="0" bb="32" group="99" />
+              <Info min="0" max="1" flag="122" seq="17" ref="0" bb="32" group="114" />
             </Parameter>
-            <Parameter id="U_Lg6AhzXke5nvqbmcs19w" name="Hydraulic conductivity" icon="Parameter" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="3.88888888888889E-11" displayUnit="ml/min/N">
+            <Parameter id="LFCB6au9f0CiwfERY_1BTA" name="Hydraulic conductivity" icon="Parameter" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="3.88888888888889E-11" displayUnit="ml/min/N">
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
               <Info min="0" flag="122" seq="17" ref="0" bb="32" group="115" />
             </Parameter>
-            <Parameter id="jt7rohAucUi15AZfgIjVbg" name="Flow fraction via large pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.8">
+            <Parameter id="eQReszvX3EOxCNufhhKFUQ" name="Radius (large pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="3.3E-07" displayUnit="µm">
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-              <Info min="0" max="1" flag="122" seq="17" ref="0" bb="32" group="114" />
+              <Info min="0" flag="122" seq="17" ref="0" bb="32" group="55" />
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                     <Tag value="TissueOrgan" />
                   </Tags>
-                  <Info min="0" max="1" flag="54" seq="1" ref="0" bb="32" group="94" />
+                  <Info min="0.75" max="0.75" flag="54" seq="1" ref="0" bb="32" group="2" />
                 </Parameter>
-                <Parameter id="qSQyoejgjkKbnEnshKpkoA" name="Density (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Density (tissue)_LiverZone" isDefault="1" displayUnit="g/cm³">
+                <Parameter id="z_A1wSkTPkO1LgisKuw1UQ" name="Density (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Density (tissue)_LiverZone" isDefault="1" displayUnit="g/cm³">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
                   <Info min="0" flag="38" seq="1" ref="0" bb="32" group="21" />
                 </Parameter>
-                <Parameter id="ipXaPjPCVE24-tB7CDJxlA" name="Allometric scale factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Allometric scale factor_LiverZone" isDefault="1">
+                <Parameter id="bvrZ4N3R10qAHpOSySWH4A" name="Fraction of blood for sampling" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Fraction of blood for sampling_LiverZone" isDefault="1">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
-                  <Info min="0.75" max="0.75" flag="54" seq="1" ref="0" bb="32" group="2" />
+                  <Info min="0" max="1" flag="54" seq="1" ref="0" bb="32" group="94" />
                 </Parameter>
-                <Parameter id="IAL7Ib9VKUOQGy8MJvpNQA" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
+                <Parameter id="laEbMFNPXEqOblCTQCi_lQ" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
                   <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
                 </Parameter>
-                <Parameter id="NxIQX8ZMNES2ByAU-6pKHg" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Volume_Periportal" isDefault="1" displayUnit="l">
+                <Parameter id="-98Va3v7WUWqzONKaPyDmg" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Volume_Periportal" isDefault="1" displayUnit="l">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
                   <Info min="0" flag="62" seq="9" ref="0" bb="32" group="65" />
                 </Parameter>
-                <Parameter id="xVs-DJXPMU6ZefQuGnZrrA" name="Radius (small pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Radius (small pores)_LiverZone" isDefault="1" displayUnit="µm">
+                <Parameter id="CXZ-wrp_6UmKyN_VkSLazg" name="Flow fraction via large pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Flow fraction via large pores_LiverZone" isDefault="1">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
-                  <Info min="0" flag="54" seq="17" ref="0" bb="32" group="99" />
+                  <Info min="0" max="1" flag="54" seq="17" ref="0" bb="32" group="114" />
                 </Parameter>
-                <Parameter id="dbIfP_nbWUWJ3MChyAKdoQ" name="Radius (large pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Radius (large pores)_LiverZone" isDefault="1" displayUnit="µm">
+                <Parameter id="Yw_Dvb1j-EiBikeyqMoVmg" name="Fluid recirculation flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate_Liver_Periportal" isDefault="1" displayUnit="l/min">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
-                  <Info min="0" flag="54" seq="17" ref="0" bb="32" group="55" />
+                  <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                  <Info min="0" flag="62" seq="17" ref="0" bb="32" group="27" />
                 </Parameter>
-                <Parameter id="nOPUNFUmMkaLHP6I_dMgKg" name="Volume (endothelium)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="VascularEndoVolume.VOLUME_VascularEndo_liv_periportal" isDefault="1" displayUnit="l">
+                <Parameter id="yUrfBuaSJEOVGFQQ8ZsJxg" name="Hydraulic conductivity" icon="Parameter" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Hydraulic conductivity_LiverZone" isDefault="1" displayUnit="ml/min/N">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
-                  <Info min="0" flag="62" seq="17" ref="0" bb="32" group="127" />
+                  <Info min="0" flag="54" seq="17" ref="0" bb="32" group="115" />
                 </Parameter>
-                <Parameter id="3w7Ikk1Ae0yWwoqv_nL7Ig" name="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Lymph_flow_rate_Liver_Periportal" isDefault="1" displayUnit="l/min">
+                <Parameter id="fM9fL6Oh-0qtQCiOHxKZNQ" name="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Lymph_flow_rate_Liver_Periportal" isDefault="1" displayUnit="l/min">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
                   <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
                   <Info min="0" flag="62" seq="17" ref="0" bb="32" group="58" />
                 </Parameter>
-                <Parameter id="IRAOh4HBi0uQAS_PjRNSWQ" name="Hydraulic conductivity" icon="Parameter" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Hydraulic conductivity_LiverZone" isDefault="1" displayUnit="ml/min/N">
+                <Parameter id="EoKcV0f0Qk6xb4phsQmhng" name="Radius (large pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Radius (large pores)_LiverZone" isDefault="1" displayUnit="µm">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
-                  <Info min="0" flag="54" seq="17" ref="0" bb="32" group="115" />
+                  <Info min="0" flag="54" seq="17" ref="0" bb="32" group="55" />
                 </Parameter>
-                <Parameter id="Rr0LymxzcEaIPjBTx-Fihg" name="Fluid recirculation flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate_Liver_Periportal" isDefault="1" displayUnit="l/min">
+                <Parameter id="QddCx5kOVUSmiEAVW26iqQ" name="Radius (small pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Radius (small pores)_LiverZone" isDefault="1" displayUnit="µm">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
-                  <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-                  <Info min="0" flag="62" seq="17" ref="0" bb="32" group="27" />
+                  <Info min="0" flag="54" seq="17" ref="0" bb="32" group="99" />
                 </Parameter>
-                <Parameter id="QDsVh4lzUUOVW36LQ0Wf7w" name="Flow fraction via large pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Flow fraction via large pores_LiverZone" isDefault="1">
+                <Parameter id="oAmLSSK2F0miMJFkS1rFbA" name="Volume (endothelium)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="VascularEndoVolume.VOLUME_VascularEndo_liv_periportal" isDefault="1" displayUnit="l">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
-                  <Info min="0" max="1" flag="54" seq="17" ref="0" bb="32" group="114" />
+                  <Info min="0" flag="62" seq="17" ref="0" bb="32" group="127" />
                 </Parameter>
-                <Parameter id="z7bqqH7ZWEqw61334vMX9w" name="Vf (neutral lipid)-PT" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (neutral lipid)-PT_LiverZone" isDefault="1">
+                <Parameter id="MKqS-sxkKUya94l6m6xGDw" name="Vf (lipid)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (lipid)_LiverZone" isDefault="1">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
-                  <Info min="0" max="1" flag="54" seq="51" ref="0" bb="32" group="86" />
+                  <Info min="0" max="1" flag="54" seq="51" ref="0" bb="32" group="85" />
                 </Parameter>
-                <Parameter id="_O0Kz9yTOU2Gmmg4I8tRIg" name="Vf (lipid)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (lipid)_LiverZone" isDefault="1">
+                <Parameter id="gvknPvFQrEe63vjGwl_LMA" name="Vf (neutral lipid)-PT" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (neutral lipid)-PT_LiverZone" isDefault="1">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
-                  <Info min="0" max="1" flag="54" seq="51" ref="0" bb="32" group="85" />
+                  <Info min="0" max="1" flag="54" seq="51" ref="0" bb="32" group="86" />
                 </Parameter>
-                <Parameter id="b9AvT89r-kigUo6jn-Cssw" name="Vf (phospholipid)-PT" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (phospholipid)-PT_LiverZone" isDefault="1">
+                <Parameter id="5E-xAqfVVkWZUpZs6dmm-A" name="Vf (phospholipid)-PT" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (phospholipid)-PT_LiverZone" isDefault="1">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
                   <Info min="0" max="1" flag="54" seq="52" ref="0" bb="32" group="86" />
                 </Parameter>
-                <Parameter id="zEF7cGiVDUiI6a_tiA21PQ" name="Vf (protein)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (protein)_LiverZone" isDefault="1">
+                <Parameter id="VuACh40Wk0CMdDpalS-pIQ" name="Vf (protein)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (protein)_LiverZone" isDefault="1">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
                   <Info min="0" max="1" flag="54" seq="52" ref="0" bb="32" group="85" />
                 </Parameter>
-                <Parameter id="Jzr9DuBVZkGwn6wyuUgysA" name="Albumin ratio (tissue/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Albumin ratio (tissue/plasma)_LiverZone" isDefault="1">
+                <Parameter id="H0hZ_l_GFE69Umkw4dlyRA" name="Albumin ratio (tissue/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Albumin ratio (tissue/plasma)_LiverZone" isDefault="1">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
                   <Info min="0" max="1" flag="54" seq="53" ref="0" bb="32" group="111" />
                 </Parameter>
-                <Parameter id="Ve-8jJ8AQEKwtmf1VMFbRA" name="Lipoprotein ratio (tissue/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Lipoprotein ratio (tissue/plasma)_LiverZone" isDefault="1">
+                <Parameter id="agIBCu9wNEuIBYoHHrduyw" name="Albumin ratio (tissue/plasma)-PT" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Albumin ratio (tissue/plasma)-PT_LiverZone" isDefault="1">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
-                  <Info min="0" max="1" flag="54" seq="53" ref="0" bb="32" group="113" />
+                  <Info min="0" max="1" flag="54" seq="53" ref="0" bb="32" group="112" />
                 </Parameter>
-                <Parameter id="aiL2PSc7z02tJcN_h65N4g" name="Vf (water)-PT" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (water)-PT_LiverZone" isDefault="1">
+                <Parameter id="x9epkY7IvEG0krMgsB2exw" name="Fraction vascular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Fraction vascular_LiverZone" isDefault="1">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
-                  <Info min="0" max="1" flag="54" seq="53" ref="0" bb="32" group="86" />
+                  <Info min="0" max="1" flag="54" seq="53" ref="0" bb="32" group="64" />
                 </Parameter>
-                <Parameter id="ekqLM-6kt0ewONkETj8Grw" name="Number of cells/g tissue" icon="Parameter" persistable="0" isFixedValue="0" dim="Count per mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Number of cells/g tissue_LiverZone" isDefault="1" displayUnit="x10^6/g">
+                <Parameter id="97ZW1Wt1kEaPR17fisRTcA" name="Lipoprotein ratio (tissue/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Lipoprotein ratio (tissue/plasma)_LiverZone" isDefault="1">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
-                  <Info min="0" max="1000000" flag="54" seq="53" ref="0" bb="32" group="61" />
+                  <Info min="0" max="1" flag="54" seq="53" ref="0" bb="32" group="113" />
                 </Parameter>
-                <Parameter id="HA26UT4xok-a6zJV3zTKGg" name="Microsomal protein mass/g tissue" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass per tissue" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Microsomal protein mass/g tissue_LiverZone" isDefault="1" displayUnit="mg/g">
+                <Parameter id="IrLWR5IHNkW9GZcVg2UaBA" name="Microsomal protein mass/g tissue" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass per tissue" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Microsomal protein mass/g tissue_LiverZone" isDefault="1" displayUnit="mg/g">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
                   <Info min="0" max="1" flag="54" seq="53" ref="0" bb="32" group="59" />
                 </Parameter>
-                <Parameter id="rBqZItR7NUKvaQHoHWH1ig" name="Albumin ratio (tissue/plasma)-PT" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Albumin ratio (tissue/plasma)-PT_LiverZone" isDefault="1">
+                <Parameter id="FJl9kMSSh0qgXs5GHGqbrw" name="Number of cells/g tissue" icon="Parameter" persistable="0" isFixedValue="0" dim="Count per mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Number of cells/g tissue_LiverZone" isDefault="1" displayUnit="x10^6/g">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
-                  <Info min="0" max="1" flag="54" seq="53" ref="0" bb="32" group="112" />
+                  <Info min="0" max="1000000" flag="54" seq="53" ref="0" bb="32" group="61" />
                 </Parameter>
-                <Parameter id="OF0kjKLNpk-mXFMe00-CNQ" name="Fraction vascular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Fraction vascular_LiverZone" isDefault="1">
+                <Parameter id="vurdPkkDR0Oj0zG9oJ3PbQ" name="Vf (water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (water)_LiverZone" isDefault="1">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
-                  <Info min="0" max="1" flag="54" seq="53" ref="0" bb="32" group="64" />
+                  <Info min="0" max="1" flag="54" seq="53" ref="0" bb="32" group="85" />
                 </Parameter>
-                <Parameter id="gg8y1I0vOUej9r7Jzf08eg" name="Vf (water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (water)_LiverZone" isDefault="1">
+                <Parameter id="4JFughLyskq-NshVxc4SOA" name="Vf (water)-PT" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (water)-PT_LiverZone" isDefault="1">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
-                  <Info min="0" max="1" flag="54" seq="53" ref="0" bb="32" group="85" />
+                  <Info min="0" max="1" flag="54" seq="53" ref="0" bb="32" group="86" />
                 </Parameter>
-                <Parameter id="v-lR7U8LtEa_WEQ5HOEeUw" name="Fraction intracellular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_f_cell_LiverZone" isDefault="1">
+                <Parameter id="8n8IATuIPkK6_EKGvmUXjA" name="Fraction intracellular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_f_cell_LiverZone" isDefault="1">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
                   <Info min="0" max="1" flag="54" seq="56" ref="0" bb="32" group="64" />
                 </Parameter>
-                <Parameter id="or5qT3VdvkmhCZHMFQm4iw" name="Fraction interstitial" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Fraction interstitial_LiverZone" isDefault="1">
+                <Parameter id="aizrOknIcUS4gHsx_rJmgg" name="Fraction interstitial" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Fraction interstitial_LiverZone" isDefault="1">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
                   <Info min="0" max="1" flag="54" seq="59" ref="0" bb="32" group="64" />
                 </Parameter>
-                <Parameter id="uDxyIkv6OE676vW23obEvw" name="Vf (neutral lipid)-RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (neutral lipid)-RR_LiverZone" isDefault="1">
+                <Parameter id="_3LKw46f2kWZ9718V53piw" name="Vf (neutral lipid)-RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (neutral lipid)-RR_LiverZone" isDefault="1">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
                   <Info min="0" max="1" flag="54" seq="85" ref="0" bb="32" group="92" />
                 </Parameter>
-                <Parameter id="5Pca1IfP6E-XhTZri7pPdw" name="Vf (neutral lipid)-WS" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (neutral lipid)-WS_LiverZone" isDefault="1">
+                <Parameter id="DVt3D87V6kCk1swM51qrDA" name="Vf (neutral lipid)-WS" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (neutral lipid)-WS_LiverZone" isDefault="1">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
                   <Info min="0" max="1" flag="54" seq="85" ref="0" bb="32" group="95" />
                 </Parameter>
-                <Parameter id="Q3ibGC1zBUSO5w06BU2Tqg" name="Vf (neutral phospholipid)-RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (neutral phospholipid)-RR_LiverZone" isDefault="1">
+                <Parameter id="NBLyNEnylUaM-UoE87jPRg" name="Vf (neutral phospholipid)-RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (neutral phospholipid)-RR_LiverZone" isDefault="1">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
                   <Info min="0" max="1" flag="54" seq="86" ref="0" bb="32" group="92" />
                 </Parameter>
-                <Parameter id="sac2jXZuwk-Z7U6AoqbBxQ" name="Vf (neutral phospholipid, plasma)-WS" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (neutral phospholipid, plasma)-WS_LiverZone" isDefault="1">
+                <Parameter id="vOAXpdf_e0Gmun6hGVW1ng" name="Vf (neutral phospholipid, plasma)-WS" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (neutral phospholipid, plasma)-WS_LiverZone" isDefault="1">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
                   <Info min="0" max="1" flag="54" seq="86" ref="0" bb="32" group="95" />
                 </Parameter>
-                <Parameter id="ZjEtbjWFNUCSrLV_1AOQag" name="Vf (protein)-WS" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (protein)-WS_LiverZone" isDefault="1">
+                <Parameter id="XqN4oRfvfUGnsqNMvF2_8g" name="Vf (extracellular water)-RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (extracellular water)-RR_LiverZone" isDefault="1">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
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                 </Parameter>
-                <Parameter id="Lcu29MD7pESBxFoUWNLq8A" name="Vf (extracellular water)-RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (extracellular water)-RR_LiverZone" isDefault="1">
+                <Parameter id="K_Wgl0H2I0C1GAjByS20gw" name="Vf (protein)-WS" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (protein)-WS_LiverZone" isDefault="1">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
-                  <Info min="0" max="1" flag="54" seq="87" ref="0" bb="32" group="92" />
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                 </Parameter>
-                <Parameter id="ggnRpzCg4UOXB7UMXd2SRQ" name="Vf (water)-WS" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (water)-WS_LiverZone" isDefault="1">
+                <Parameter id="jucfhA-s2UqNoBLm4n1Wjw" name="Vf (intracellular water)-RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (intracellular water)-RR_LiverZone" isDefault="1">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
-                  <Info min="0" max="1" flag="54" seq="88" ref="0" bb="32" group="95" />
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                 </Parameter>
-                <Parameter id="CgfoDCWgMEqTnOxqZUWniw" name="Vf (intracellular water)-RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (intracellular water)-RR_LiverZone" isDefault="1">
+                <Parameter id="vnOzW-ruvECvmShlAq97RQ" name="Vf (water)-WS" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (water)-WS_LiverZone" isDefault="1">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
-                  <Info min="0" max="1" flag="54" seq="88" ref="0" bb="32" group="92" />
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                 </Parameter>
-                <Parameter id="2ds4WaLeB0yFuGvFQ1NutA" name="Acidic phospholipids [mg/g] - RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Acidic phospholipids [mg/g] - RR_LiverZone" isDefault="1">
+                <Parameter id="s9h4yETi_E-_U6nwfBklJw" name="Acidic phospholipids [mg/g] - RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Acidic phospholipids [mg/g] - RR_LiverZone" isDefault="1">
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+                <Parameter id="1ChP11dmk0yEst1qcoXong" name="Vf (acidic phospholipids)-WS" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (acidic phospholipids)-WS_LiverZone" isDefault="1">
                   <Tags>
                     <Tag value="TissueOrgan" />
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+                <Parameter id="smvsPH97oEyHRh1PO4fgcQ" name="Specific blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Specific blood flow rate_LiverZone" isDefault="1" displayUnit="ml/min/100g organ">
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                     <Tag value="TissueOrgan" />
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+                <Parameter id="Vn8Gv8sJi0qqjF8Zmd3xIQ" name="Blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_from_Qspec_LiverZone" isDefault="1" displayUnit="l/min">
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                 </Parameter>
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+                <Container id="bo4cNXLni0i__twz_kf3zw" name="Plasma" mode="Physical" containerType="Compartment">
                   <Tags>
                     <Tag value="Liver" />
                     <Tag value="Periportal" />
                   </Tags>
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+                    <Parameter id="199T2jyOjEmwTHNsJmGYAg" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
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                     </Parameter>
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+                    <Parameter id="-BThUEcYK0yTvDASpjCEOw" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" isDefault="1" displayUnit="l">
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+                    <Container id="ZrYccE8ZGUic4cSW5KgF7A" name="MoleculeProperties" mode="Logical" containerType="Molecule">
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-                        <Parameter id="LADTrQeQ30mLcxlb7i5ryA" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                        <Parameter id="KscmlRJAaECEugtSDsb-kQ" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                           <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                         </Parameter>
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+                        <Parameter id="_OYCUR9rqkqc9sEo9rcZ7g" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" isDefault="1">
                           <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                         </Parameter>
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+                        <Parameter id="EQO9KOcLmECqGlzRiXF85g" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
                           <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
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                   </Children>
                 </Container>
-                <Container id="OOKAJBi8FU6IijIFPRHPcQ" name="BloodCells" mode="Physical" containerType="Compartment">
+                <Container id="T23Nmml0lkOrwg34wc2z-g" name="BloodCells" mode="Physical" containerType="Compartment">
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                     <Tag value="Liver" />
                     <Tag value="Periportal" />
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+                    <Parameter id="flb2yVsRB0uK6tEnFvC7qQ" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
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+                    <Parameter id="XrmUKkaywUm8LwZ5Oqr6Yg" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" isDefault="1" displayUnit="l">
                       <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
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                     </Parameter>
-                    <Container id="CYvNZ9YuWECYQyG61ESZ7A" name="MoleculeProperties" mode="Logical" containerType="Molecule">
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+                        <Parameter id="oaOhOsKSjUi3ZGAAS8yzjA" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                          <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                        </Parameter>
+                        <Parameter id="OJMoGgnuDkuc7b32SDNEfw" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" isDefault="1">
                           <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
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+                        <Parameter id="DGgpiUjCqE-wFU1_2QyteQ" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
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+                <Container id="lY67q6iJEESxJEDVtYq9Cw" name="Interstitial" mode="Physical" containerType="Compartment">
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+                    <Parameter id="ncQq3hQRlEqufAXY3GkgdA" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" isDefault="1" displayUnit="l">
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+                    <Parameter id="cKdQNc6y90aQOQRCYzWipA" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_pH_INT" isDefault="1">
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+                        <Parameter id="EBCzWsc1_UOqViBb_EGnJQ" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_liv" isDefault="1">
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+                        <Parameter id="nSIV0CgX6UmGS_mYJBM9Tg" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
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+                    <Parameter id="8RQ_0b8xD0uTkwYuhF_CYQ" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" isDefault="1" displayUnit="l">
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+                    <Parameter id="j2GN5DMRO0KVhh8qM7PRaQ" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" isDefault="1" displayUnit="l">
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+                    <Parameter id="-__79Ngvz0yFez3cDfSsXw" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_PH_Cell_LiverZone" isDefault="1">
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                         <Tag value="Periportal" />
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                     </Parameter>
-                    <Container id="bNrP1jnSbUGAyIqRh4EM-g" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                    <Container id="zmjRX7ahHESGhrFs33eJRw" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                       <Children>
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+                        <Parameter id="0N0CH5XKK0WkYjfNbsHnJA" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                           <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
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+                        <Parameter id="hq2slLPZBUyMDjHCSUKNdQ" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_liv" isDefault="1">
                           <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                         </Parameter>
-                        <Parameter id="CdfXm3mdR0KuIdva_jQFFA" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
+                        <Parameter id="WNSYk3DukEuN3E4ALMZXig" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
                           <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                         </Parameter>
                       </Children>
@@ -11199,401 +11260,401 @@
                 </Container>
               </Children>
             </Container>
-            <Container id="11QEt3af-0qlyQmFD00NKA" name="Pericentral" mode="Logical" containerType="Compartment">
+            <Container id="sONd_bbmt0ayE-X1dNj7Kg" name="Pericentral" mode="Logical" containerType="Compartment">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <Children>
-                <Parameter id="GsQl53IZyUWkknZEavkp2A" name="Allometric scale factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Allometric scale factor_LiverZone" isDefault="1">
+                <Parameter id="-eOXuRrikku-JO8HPq6-Iw" name="Allometric scale factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Allometric scale factor_LiverZone" isDefault="1">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
                   <Info min="0.75" max="0.75" flag="54" seq="1" ref="0" bb="32" group="2" />
                 </Parameter>
-                <Parameter id="-OFxaZ5qaUeESSq0izPSag" name="Density (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Density (tissue)_LiverZone" isDefault="1" displayUnit="g/cm³">
+                <Parameter id="YuxF9QkyTUGRiI-kyIwUIg" name="Density (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Density (tissue)_LiverZone" isDefault="1" displayUnit="g/cm³">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
                   <Info min="0" flag="38" seq="1" ref="0" bb="32" group="21" />
                 </Parameter>
-                <Parameter id="gWkk_rmi5ku-QKSyeThyTg" name="Fraction of blood for sampling" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Fraction of blood for sampling_LiverZone" isDefault="1">
+                <Parameter id="KoXygnP0fUq5_7bcFTJCgA" name="Fraction of blood for sampling" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Fraction of blood for sampling_LiverZone" isDefault="1">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
                   <Info min="0" max="1" flag="54" seq="1" ref="0" bb="32" group="94" />
                 </Parameter>
-                <Parameter id="8DHdHNRLOEqZPQKOPXkbDA" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
+                <Parameter id="95GopRw2fEK9Hq2sijDFxg" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
                   <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
                 </Parameter>
-                <Parameter id="7IKrseTWokSauE30stubXA" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Volume_Pericentral" isDefault="1" displayUnit="l">
+                <Parameter id="tke4yKV-OEiQxqqu72KpIg" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Volume_Pericentral" isDefault="1" displayUnit="l">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
                   <Info min="0" flag="62" seq="10" ref="0" bb="32" group="65" />
                 </Parameter>
-                <Parameter id="n8gcMTsNVkivzkfU_OJ8yQ" name="Radius (small pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Radius (small pores)_LiverZone" isDefault="1" displayUnit="µm">
+                <Parameter id="3RQ56xgA-U-buwkTv2m0-Q" name="Flow fraction via large pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Flow fraction via large pores_LiverZone" isDefault="1">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
-                  <Info min="0" flag="54" seq="17" ref="0" bb="32" group="99" />
+                  <Info min="0" max="1" flag="54" seq="17" ref="0" bb="32" group="114" />
                 </Parameter>
-                <Parameter id="ddTsU6Y-I0eaktxB-VmUSg" name="Flow fraction via large pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Flow fraction via large pores_LiverZone" isDefault="1">
+                <Parameter id="xzXJz3nU1EW6GmqKJQTrBA" name="Hydraulic conductivity" icon="Parameter" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Hydraulic conductivity_LiverZone" isDefault="1" displayUnit="ml/min/N">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
-                  <Info min="0" max="1" flag="54" seq="17" ref="0" bb="32" group="114" />
+                  <Info min="0" flag="54" seq="17" ref="0" bb="32" group="115" />
                 </Parameter>
-                <Parameter id="FHTNd3pSK06JO4EML-SRTw" name="Hydraulic conductivity" icon="Parameter" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Hydraulic conductivity_LiverZone" isDefault="1" displayUnit="ml/min/N">
+                <Parameter id="dVWZjXem6Eexfq1q4Q-Jbw" name="Radius (large pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Radius (large pores)_LiverZone" isDefault="1" displayUnit="µm">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
-                  <Info min="0" flag="54" seq="17" ref="0" bb="32" group="115" />
+                  <Info min="0" flag="54" seq="17" ref="0" bb="32" group="55" />
                 </Parameter>
-                <Parameter id="Ke3iaAXzmUqEBoxK1intiA" name="Radius (large pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Radius (large pores)_LiverZone" isDefault="1" displayUnit="µm">
+                <Parameter id="6So3GxIJT0GgDv9auoFuug" name="Radius (small pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Radius (small pores)_LiverZone" isDefault="1" displayUnit="µm">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
-                  <Info min="0" flag="54" seq="17" ref="0" bb="32" group="55" />
+                  <Info min="0" flag="54" seq="17" ref="0" bb="32" group="99" />
                 </Parameter>
-                <Parameter id="7v4kFvUOG0-JK0jZq9a4OQ" name="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Lymph_flow_rate_Liver_Pericentral" isDefault="1" displayUnit="l/min">
+                <Parameter id="8cN985iwwESteAIWT5IiOQ" name="Fluid recirculation flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate_Liver_Pericentral" isDefault="1" displayUnit="l/min">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
                   <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-                  <Info min="0" flag="62" seq="18" ref="0" bb="32" group="58" />
+                  <Info min="0" flag="62" seq="18" ref="0" bb="32" group="27" />
                 </Parameter>
-                <Parameter id="KYKGtIGrp024HrizHB_i7w" name="Fluid recirculation flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate_Liver_Pericentral" isDefault="1" displayUnit="l/min">
+                <Parameter id="kzbE2cNP1kCJqURv3-_XDQ" name="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Lymph_flow_rate_Liver_Pericentral" isDefault="1" displayUnit="l/min">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
                   <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-                  <Info min="0" flag="62" seq="18" ref="0" bb="32" group="27" />
+                  <Info min="0" flag="62" seq="18" ref="0" bb="32" group="58" />
                 </Parameter>
-                <Parameter id="TRX9Tc7mO0-Mr1bnqLjiQg" name="Volume (endothelium)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="VascularEndoVolume.VOLUME_VascularEndo_liv_pericentral" isDefault="1" displayUnit="l">
+                <Parameter id="njn8gu-ep0GgCPN-ibXKUg" name="Volume (endothelium)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="VascularEndoVolume.VOLUME_VascularEndo_liv_pericentral" isDefault="1" displayUnit="l">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
                   <Info min="0" flag="62" seq="18" ref="0" bb="32" group="127" />
                 </Parameter>
-                <Parameter id="MkhXSXd2o0ebYra-s7C4TA" name="Vf (lipid)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (lipid)_LiverZone" isDefault="1">
+                <Parameter id="zMrDo4zrPEmiVBBzqCSRrg" name="Vf (lipid)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (lipid)_LiverZone" isDefault="1">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
                   <Info min="0" max="1" flag="54" seq="51" ref="0" bb="32" group="85" />
                 </Parameter>
-                <Parameter id="2CalWfaXg0mypnbgfa7_vQ" name="Vf (neutral lipid)-PT" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (neutral lipid)-PT_LiverZone" isDefault="1">
+                <Parameter id="kI_IkgltjUy6agLDbbioag" name="Vf (neutral lipid)-PT" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (neutral lipid)-PT_LiverZone" isDefault="1">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
                   <Info min="0" max="1" flag="54" seq="51" ref="0" bb="32" group="86" />
                 </Parameter>
-                <Parameter id="xJUfQtwxw0CeJGzwNPd2MQ" name="Vf (phospholipid)-PT" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (phospholipid)-PT_LiverZone" isDefault="1">
+                <Parameter id="NqYKwobbI02ANs3m2yzsJA" name="Fraction vascular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Fraction vascular_LiverZone" isDefault="1">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
-                  <Info min="0" max="1" flag="54" seq="52" ref="0" bb="32" group="86" />
+                  <Info min="0" max="1" flag="54" seq="52" ref="0" bb="32" group="64" />
                 </Parameter>
-                <Parameter id="gzBJjVkvtE-H2ESdFxOZIQ" name="Vf (protein)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (protein)_LiverZone" isDefault="1">
+                <Parameter id="EKo6AHRj7EKKYNi2eyMxDg" name="Vf (phospholipid)-PT" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (phospholipid)-PT_LiverZone" isDefault="1">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
-                  <Info min="0" max="1" flag="54" seq="52" ref="0" bb="32" group="85" />
+                  <Info min="0" max="1" flag="54" seq="52" ref="0" bb="32" group="86" />
                 </Parameter>
-                <Parameter id="kBdIESoMdkqaPl1hmE-DMw" name="Fraction vascular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Fraction vascular_LiverZone" isDefault="1">
+                <Parameter id="IJyyItJ1i0uABfkk0Nz0iQ" name="Vf (protein)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (protein)_LiverZone" isDefault="1">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
-                  <Info min="0" max="1" flag="54" seq="52" ref="0" bb="32" group="64" />
+                  <Info min="0" max="1" flag="54" seq="52" ref="0" bb="32" group="85" />
                 </Parameter>
-                <Parameter id="bLUrOBfx20qNSufYv_J-gw" name="Lipoprotein ratio (tissue/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Lipoprotein ratio (tissue/plasma)_LiverZone" isDefault="1">
+                <Parameter id="ubvd8rJKGkqi95Fgm5i7lg" name="Albumin ratio (tissue/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Albumin ratio (tissue/plasma)_LiverZone" isDefault="1">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
-                  <Info min="0" max="1" flag="54" seq="53" ref="0" bb="32" group="113" />
+                  <Info min="0" max="1" flag="54" seq="53" ref="0" bb="32" group="111" />
                 </Parameter>
-                <Parameter id="XEikODlg-E66eGGGv4ZyZw" name="Vf (water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (water)_LiverZone" isDefault="1">
+                <Parameter id="imy0BnM2XE6fGERBqhu4Hg" name="Albumin ratio (tissue/plasma)-PT" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Albumin ratio (tissue/plasma)-PT_LiverZone" isDefault="1">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
-                  <Info min="0" max="1" flag="54" seq="53" ref="0" bb="32" group="85" />
+                  <Info min="0" max="1" flag="54" seq="53" ref="0" bb="32" group="112" />
                 </Parameter>
-                <Parameter id="fG8yz9kJgEqiwBTVBlAl-w" name="Vf (water)-PT" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (water)-PT_LiverZone" isDefault="1">
+                <Parameter id="Z1cHlrBADUGLhSA2fKOUyw" name="Lipoprotein ratio (tissue/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Lipoprotein ratio (tissue/plasma)_LiverZone" isDefault="1">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
-                  <Info min="0" max="1" flag="54" seq="53" ref="0" bb="32" group="86" />
+                  <Info min="0" max="1" flag="54" seq="53" ref="0" bb="32" group="113" />
                 </Parameter>
-                <Parameter id="3KqK7cc-1U6SMlUjRBnqzg" name="Number of cells/g tissue" icon="Parameter" persistable="0" isFixedValue="0" dim="Count per mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Number of cells/g tissue_LiverZone" isDefault="1" displayUnit="x10^6/g">
+                <Parameter id="rZIxpXfPNEegCy4HFYkPcw" name="Microsomal protein mass/g tissue" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass per tissue" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Microsomal protein mass/g tissue_LiverZone" isDefault="1" displayUnit="mg/g">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
-                  <Info min="0" max="1000000" flag="54" seq="53" ref="0" bb="32" group="61" />
+                  <Info min="0" max="1" flag="54" seq="53" ref="0" bb="32" group="59" />
                 </Parameter>
-                <Parameter id="r-bkEHJetEa21n_Y7iym1Q" name="Microsomal protein mass/g tissue" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass per tissue" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Microsomal protein mass/g tissue_LiverZone" isDefault="1" displayUnit="mg/g">
+                <Parameter id="MScAQi_5yUmZI5kUTWTb-A" name="Number of cells/g tissue" icon="Parameter" persistable="0" isFixedValue="0" dim="Count per mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Number of cells/g tissue_LiverZone" isDefault="1" displayUnit="x10^6/g">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
-                  <Info min="0" max="1" flag="54" seq="53" ref="0" bb="32" group="59" />
+                  <Info min="0" max="1000000" flag="54" seq="53" ref="0" bb="32" group="61" />
                 </Parameter>
-                <Parameter id="2jEma9wgAUqz7YqQ45AsiQ" name="Albumin ratio (tissue/plasma)-PT" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Albumin ratio (tissue/plasma)-PT_LiverZone" isDefault="1">
+                <Parameter id="YfK68OQc6UKfA1E0ofp4tg" name="Vf (water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (water)_LiverZone" isDefault="1">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
-                  <Info min="0" max="1" flag="54" seq="53" ref="0" bb="32" group="112" />
+                  <Info min="0" max="1" flag="54" seq="53" ref="0" bb="32" group="85" />
                 </Parameter>
-                <Parameter id="6R15cGXyc0WZ-9dnVkS13w" name="Albumin ratio (tissue/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Albumin ratio (tissue/plasma)_LiverZone" isDefault="1">
+                <Parameter id="M28bhwMTMkiLkFjT6XBnIw" name="Vf (water)-PT" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (water)-PT_LiverZone" isDefault="1">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
-                  <Info min="0" max="1" flag="54" seq="53" ref="0" bb="32" group="111" />
+                  <Info min="0" max="1" flag="54" seq="53" ref="0" bb="32" group="86" />
                 </Parameter>
-                <Parameter id="Fxf_lkUne0icOCvuh1YXJw" name="Fraction intracellular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_f_cell_LiverZone" isDefault="1">
+                <Parameter id="PHQwJm65XU2Dc8ZhSJzh9A" name="Fraction intracellular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_f_cell_LiverZone" isDefault="1">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
                   <Info min="0" max="1" flag="54" seq="55" ref="0" bb="32" group="64" />
                 </Parameter>
-                <Parameter id="qsdFKKPt9UakbjwBeIooww" name="Fraction interstitial" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Fraction interstitial_LiverZone" isDefault="1">
+                <Parameter id="ge2KmNu4YE6D6Y8cPYoEug" name="Fraction interstitial" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Fraction interstitial_LiverZone" isDefault="1">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
                   <Info min="0" max="1" flag="54" seq="58" ref="0" bb="32" group="64" />
                 </Parameter>
-                <Parameter id="14Y41NqDqEmxenNDD4x_Jg" name="Vf (neutral lipid)-RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (neutral lipid)-RR_LiverZone" isDefault="1">
+                <Parameter id="T5Nv42ygt06aZB1pLeVgPg" name="Vf (neutral lipid)-RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (neutral lipid)-RR_LiverZone" isDefault="1">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
                   <Info min="0" max="1" flag="54" seq="85" ref="0" bb="32" group="92" />
                 </Parameter>
-                <Parameter id="-c1pVBAY8E2jg5vEXmJdsA" name="Vf (neutral lipid)-WS" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (neutral lipid)-WS_LiverZone" isDefault="1">
+                <Parameter id="7_fYeo_tWUSXfTvfsXy-fg" name="Vf (neutral lipid)-WS" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (neutral lipid)-WS_LiverZone" isDefault="1">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
                   <Info min="0" max="1" flag="54" seq="85" ref="0" bb="32" group="95" />
                 </Parameter>
-                <Parameter id="qtTDRciyv0WliMg4lwS4zQ" name="Vf (neutral phospholipid)-RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (neutral phospholipid)-RR_LiverZone" isDefault="1">
+                <Parameter id="utK57HsdVkuB-PZgCzJ5_w" name="Vf (neutral phospholipid)-RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (neutral phospholipid)-RR_LiverZone" isDefault="1">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
                   <Info min="0" max="1" flag="54" seq="86" ref="0" bb="32" group="92" />
                 </Parameter>
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+                <Parameter id="uFm71qbMNEmQve-suBCfMA" name="Vf (neutral phospholipid, plasma)-WS" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (neutral phospholipid, plasma)-WS_LiverZone" isDefault="1">
                   <Tags>
                     <Tag value="TissueOrgan" />
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                 </Parameter>
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+                <Parameter id="iyn68c1vWUi0YhpSY0uTEg" name="Vf (extracellular water)-RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (extracellular water)-RR_LiverZone" isDefault="1">
                   <Tags>
                     <Tag value="TissueOrgan" />
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                 </Parameter>
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+                <Parameter id="Fdnei6DYOUWNLYFhzFhBBw" name="Vf (protein)-WS" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (protein)-WS_LiverZone" isDefault="1">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
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                 </Parameter>
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+                <Parameter id="GObrAm-m70CgBv2O9adjgw" name="Vf (intracellular water)-RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (intracellular water)-RR_LiverZone" isDefault="1">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
                   <Info min="0" max="1" flag="54" seq="88" ref="0" bb="32" group="92" />
                 </Parameter>
-                <Parameter id="wfj3DMqe4EuOWrwTTGyqgA" name="Vf (water)-WS" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (water)-WS_LiverZone" isDefault="1">
+                <Parameter id="5syIhcc5MUuhXJMXF5n4Qg" name="Vf (water)-WS" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (water)-WS_LiverZone" isDefault="1">
                   <Tags>
                     <Tag value="TissueOrgan" />
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                   <Info min="0" max="1" flag="54" seq="88" ref="0" bb="32" group="95" />
                 </Parameter>
-                <Parameter id="TBbJmJc5sky1Mh6Bk9A6cw" name="Acidic phospholipids [mg/g] - RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Acidic phospholipids [mg/g] - RR_LiverZone" isDefault="1">
+                <Parameter id="CLnHTPfNQEGojDK1pN6yqw" name="Acidic phospholipids [mg/g] - RR" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Acidic phospholipids [mg/g] - RR_LiverZone" isDefault="1">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
                   <Info min="0" max="1000" flag="54" seq="89" ref="0" bb="32" group="92" />
                 </Parameter>
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+                <Parameter id="b_rxwSS38EC4DBL1e4d_Tg" name="Vf (acidic phospholipids)-WS" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Vf (acidic phospholipids)-WS_LiverZone" isDefault="1">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
                   <Info min="0" max="1" flag="54" seq="89" ref="0" bb="32" group="95" />
                 </Parameter>
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+                <Parameter id="mjq_LHzezk6X83f67_wsxQ" name="Specific blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Specific blood flow rate_LiverZone" isDefault="1" displayUnit="ml/min/100g organ">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
                   <Info min="0" flag="54" seq="141" ref="0" bb="32" group="5" />
                 </Parameter>
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+                <Parameter id="vE-TJRWLLkeNHC5XfaOJmQ" name="Blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_from_Qspec_LiverZone" isDefault="1" displayUnit="l/min">
                   <Tags>
                     <Tag value="TissueOrgan" />
                   </Tags>
                   <Info min="0" flag="54" seq="142" ref="0" bb="32" group="5" />
                 </Parameter>
-                <Container id="XVqARQRMDECaH3XJRZV4Sg" name="Plasma" mode="Physical" containerType="Compartment">
+                <Container id="_pV4Se-Z9UWuyrB2KgwaBg" name="Plasma" mode="Physical" containerType="Compartment">
                   <Tags>
                     <Tag value="Liver" />
                     <Tag value="Pericentral" />
                   </Tags>
                   <Children>
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+                    <Parameter id="Rqfe12Tua0ewqMIIyMmPhA" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                     </Parameter>
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+                    <Parameter id="Dcog-CDCLkCtzuqxCjsMVw" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" isDefault="1" displayUnit="l">
                       <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
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                     </Parameter>
-                    <Container id="dbPwuuF1Qk-0EwPd3Z6Exg" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                    <Container id="XvRnEm0pXEKMMPG80m4IuQ" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                       <Children>
-                        <Parameter id="kL-aUdSayEisFdsZWVUKGw" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
-                          <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
-                        </Parameter>
-                        <Parameter id="IPQjkoZcGkyDtlWn7VGTRw" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                        <Parameter id="l8KESXRJzUSK2ZjLh-uRjQ" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                           <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                         </Parameter>
-                        <Parameter id="EtQLBS1HvEqooEngDgR-_A" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" isDefault="1">
+                        <Parameter id="dlj8TGDw5UKbftplg71iTw" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" isDefault="1">
                           <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                         </Parameter>
+                        <Parameter id="toj6km9a60G9ejwVilMd7A" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
+                          <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                        </Parameter>
                       </Children>
                     </Container>
                   </Children>
                 </Container>
-                <Container id="sE94UOAqcEKpa4myEChUXQ" name="BloodCells" mode="Physical" containerType="Compartment">
+                <Container id="7e5U6PFOBUiXJLUy75uuuA" name="BloodCells" mode="Physical" containerType="Compartment">
                   <Tags>
                     <Tag value="Liver" />
                     <Tag value="Pericentral" />
                   </Tags>
                   <Children>
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+                    <Parameter id="JLQzHDbO0EyX7kZ4xTWFSg" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                     </Parameter>
-                    <Parameter id="F6_0guOW1EqusMkNPpYkUA" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" isDefault="1" displayUnit="l">
+                    <Parameter id="eWapj6fJgEm4ZBazeBuGXQ" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" isDefault="1" displayUnit="l">
                       <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                       <Info min="0" flag="62" seq="17" ref="0" bb="2" group="121" />
                     </Parameter>
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+                    <Container id="-0fRg4int0OR4zU0_yyB2w" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                       <Children>
-                        <Parameter id="IcSNKj4sekCiwCZ55Mw6OQ" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
-                          <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                        <Parameter id="0pzv4SD8hE6qafw4ExOMRA" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                          <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                         </Parameter>
-                        <Parameter id="ZrMlRNroaUK-SH-gSJS2_Q" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" isDefault="1">
+                        <Parameter id="BRT77mkMNE6c-Ywyaiz2VQ" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" isDefault="1">
                           <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                         </Parameter>
-                        <Parameter id="HL_ywxx8iUezoOEZEPCu-Q" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
-                          <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                        <Parameter id="a0WnHsgtn0ajxtmn4gEPIA" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
+                          <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                         </Parameter>
                       </Children>
                     </Container>
                   </Children>
                 </Container>
-                <Container id="liEs12AWh06kmbhjBeR7lg" name="Interstitial" mode="Physical" containerType="Compartment">
+                <Container id="K1IcAQchgkipK5dg5KDWXg" name="Interstitial" mode="Physical" containerType="Compartment">
                   <Tags>
                     <Tag value="Liver" />
                     <Tag value="Pericentral" />
                   </Tags>
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+                    <Parameter id="0G-AEqjaUUynoBqOFSO8Eg" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                     </Parameter>
-                    <Parameter id="VR3UoIal50eDcBQIYX2b-w" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" isDefault="1" displayUnit="l">
+                    <Parameter id="iw2Juui5k0-cFpD4lxvuIA" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" isDefault="1" displayUnit="l">
                       <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                       <Info min="0" flag="62" seq="17" ref="0" bb="2" group="124" />
                     </Parameter>
-                    <Parameter id="IQqVtrykGUui7PEGXJOJCw" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_pH_INT" isDefault="1">
+                    <Parameter id="p2ZmWWvGDEGBLn8p6SXqUA" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_pH_INT" isDefault="1">
                       <Tags>
                         <Tag value="Liver" />
                         <Tag value="Pericentral" />
                       </Tags>
                       <Info min="0" max="14" flag="122" seq="55" ref="0" bb="32" group="84" />
                     </Parameter>
-                    <Container id="eHxs3pxmNUCLJnmAWJDinQ" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                    <Container id="zYIul6PF4UKT0LXqmxC-NA" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                       <Children>
-                        <Parameter id="kz26TLclj0yS0Jv6cR6pDA" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                        <Parameter id="E2MBIe06DE2PutRNXpJDvA" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                           <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                         </Parameter>
-                        <Parameter id="WO-t-uIVLEqn6H0GFqNcsg" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
-                          <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
-                        </Parameter>
-                        <Parameter id="CysbKSxpJE6KYBxVsmm24Q" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_liv" isDefault="1">
+                        <Parameter id="awb8IlFzCk-1q-mRbk2Y4Q" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_liv" isDefault="1">
                           <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                         </Parameter>
+                        <Parameter id="FqruPpA-XU61oW5Tuwyyqw" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
+                          <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                        </Parameter>
                       </Children>
                     </Container>
                   </Children>
                 </Container>
-                <Container id="bJp2QRIu_kmSB4k_-yDzPQ" name="Intracellular" mode="Physical" containerType="Compartment">
+                <Container id="mnTadGjxaEG5njWMX7v14A" name="Intracellular" mode="Physical" containerType="Compartment">
                   <Tags>
                     <Tag value="Liver" />
                     <Tag value="Pericentral" />
                   </Tags>
                   <Children>
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+                    <Parameter id="rvEJWJT9aEiyfV3mHO8f7A" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" isDefault="1" displayUnit="l">
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                     </Parameter>
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+                    <Parameter id="vWlBEi16sE6RfnnzJxF9qA" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" isDefault="1" displayUnit="l">
                       <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                       <Info min="0" flag="62" seq="17" ref="0" bb="2" group="125" />
                     </Parameter>
-                    <Parameter id="bhplXjdbz0CQZzjLUTkP1w" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_PH_Cell_LiverZone" isDefault="1">
+                    <Parameter id="JPLUTOE3yUKd1hpL41JpPw" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_PH_Cell_LiverZone" isDefault="1">
                       <Tags>
                         <Tag value="Liver" />
                         <Tag value="Pericentral" />
                       </Tags>
                       <Info min="0" max="14" flag="122" seq="56" ref="0" bb="32" group="83" />
                     </Parameter>
-                    <Container id="x7bQL-zDqES7uI_cfVVZBA" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                    <Container id="MuR1QDSbvUesR_CH2fM6nw" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                       <Children>
-                        <Parameter id="5WDZCOjCpUygj4xA-H2kWw" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_liv" isDefault="1">
+                        <Parameter id="iVz-iKjWLkyk0b3RUnDxFw" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                          <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                        </Parameter>
+                        <Parameter id="GqxfB-nbQ0KTM_665iX_pw" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_liv" isDefault="1">
                           <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                         </Parameter>
-                        <Parameter id="DEZUezDG8k2y498-OuqX_A" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
+                        <Parameter id="M50ymvNCPUS7IXmUWLpD7A" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
                           <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                         </Parameter>
-                        <Parameter id="jY-X7EOmLEiS2m-NANZBTA" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
-                          <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
-                        </Parameter>
                       </Children>
                     </Container>
                   </Children>
                 </Container>
               </Children>
             </Container>
-            <Container id="wXRbBre0Ekm80r57lNH1XQ" name="Plasma" mode="Logical" containerType="Compartment">
+            <Container id="8m0ms6ShSkWmK-nKMx_RYw" name="Plasma" mode="Logical" containerType="Compartment">
               <Tags>
                 <Tag value="Liver" />
               </Tags>
               <Children>
-                <Parameter id="yeWAhE6-z0KoSHhAgkD6bg" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" isDefault="1" displayUnit="l">
+                <Parameter id="Ui88eo-pqUS9QE0xLurgwQ" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" isDefault="1" displayUnit="l">
                   <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                   <Info min="0" flag="62" seq="17" ref="0" bb="2" group="126" />
                 </Parameter>
               </Children>
             </Container>
-            <Container id="70sGTidy8kOYGjb8Li5tYA" name="BloodCells" mode="Logical" containerType="Compartment">
+            <Container id="5yAzrQR86kmgnsZR5rQrBA" name="BloodCells" mode="Logical" containerType="Compartment">
               <Tags>
                 <Tag value="Liver" />
               </Tags>
               <Children>
-                <Parameter id="AD1nKf-ZwkWAWXcVC_1snA" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" isDefault="1" displayUnit="l">
+                <Parameter id="mTjnUUdTukWgYIkxOZO7aQ" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" isDefault="1" displayUnit="l">
                   <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                   <Info min="0" flag="62" seq="17" ref="0" bb="2" group="121" />
                 </Parameter>
               </Children>
             </Container>
-            <Container id="A9p5qmrMe0u5GiXk1fU5Og" name="Interstitial" mode="Logical" containerType="Compartment">
+            <Container id="0-Er_XIHeUWRpTXdtYu1kQ" name="Interstitial" mode="Logical" containerType="Compartment">
               <Tags>
                 <Tag value="Liver" />
               </Tags>
               <Children>
-                <Parameter id="Y9J4FQMvC0CyhNrMRhbRHg" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" isDefault="1" displayUnit="l">
+                <Parameter id="wswbr94t3UmBGFF7W0CnaA" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" isDefault="1" displayUnit="l">
                   <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                   <Info min="0" flag="62" seq="17" ref="0" bb="2" group="124" />
                 </Parameter>
-                <Parameter id="IEy5VW0NFUWWN-bnsvtqSw" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_pH_INT" isDefault="1">
+                <Parameter id="AYVwrIAJC06yt2b5YZAVpA" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_pH_INT" isDefault="1">
                   <Tags>
                     <Tag value="Liver" />
                   </Tags>
@@ -11601,16 +11662,16 @@
                 </Parameter>
               </Children>
             </Container>
-            <Container id="CIzbkeRnC0yHQ3CVJbt3NA" name="Intracellular" mode="Logical" containerType="Compartment">
+            <Container id="tvL5Jry1NE-pskHY1VrAnA" name="Intracellular" mode="Logical" containerType="Compartment">
               <Tags>
                 <Tag value="Liver" />
               </Tags>
               <Children>
-                <Parameter id="Ptv3YNV29kaiDl7d00l_0w" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" isDefault="1" displayUnit="l">
+                <Parameter id="bgyGC8l9fECrk-ICFRF7cg" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" isDefault="1" displayUnit="l">
                   <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                   <Info min="0" flag="62" seq="17" ref="0" bb="2" group="125" />
                 </Parameter>
-                <Parameter id="18P5et2NcEWAVKV4jnl97w" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.23">
+                <Parameter id="VpBa_lBLiESl0j37HhHBsA" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.23">
                   <Tags>
                     <Tag value="Liver" />
                   </Tags>
@@ -11621,391 +11682,393 @@
             </Container>
           </Children>
         </Container>
-        <Container id="iOCDcy7r3EKUYmKbudHb9A" name="Lung" mode="Logical" containerType="Organ">
+        <Container id="KRuv-1FZAECgQeT-CaOVqw" name="Lung" mode="Logical" containerType="Organ">
           <Tags>
             <Tag value="TissueOrgan" />
           </Tags>
           <Children>
-            <Parameter id="gA33axPDkUiwqzI4EBwxzg" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
+            <Parameter id="Xibs1KsKeUG39lkza5LWew" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
             </Parameter>
-            <Parameter id="CzgGCoqpakGel9qkfwUx6A" name="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Lymph_flow_rate" isDefault="1" displayUnit="l/min">
+            <Parameter id="IolUa165aUGgqD7wh8dFXQ" name="Fluid recirculation flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate" isDefault="1" displayUnit="l/min">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-              <Info min="0" flag="122" seq="18" ref="0" bb="32" group="58" />
+              <Info min="0" flag="122" seq="18" ref="0" bb="32" group="27" />
             </Parameter>
-            <Parameter id="M8kJkqoGekmOahsYILGLpQ" name="Fluid recirculation flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate" isDefault="1" displayUnit="l/min">
+            <Parameter id="epD3xjNzLkWmZxl5qntXjA" name="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Lymph_flow_rate" isDefault="1" displayUnit="l/min">
               <Tags>
                 <Tag value="TissueOrgan" />
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               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-              <Info min="0" flag="122" seq="18" ref="0" bb="32" group="27" />
+              <Info min="0" flag="122" seq="18" ref="0" bb="32" group="58" />
             </Parameter>
-            <Parameter id="guYcJbkRxEGLX99b1evJ0w" name="Volume (endothelium)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="VascularEndoVolume.VOLUME_VascularEndo_lng" isDefault="1" displayUnit="l">
+            <Parameter id="Iax5mtY9GUSq4XFZ6DxR7w" name="Volume (endothelium)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="VascularEndoVolume.VOLUME_VascularEndo_lng" isDefault="1" displayUnit="l">
               <Tags>
                 <Tag value="TissueOrgan" />
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               <Info min="0" flag="62" seq="18" ref="0" bb="32" group="127" />
             </Parameter>
-            <Parameter id="JFKeZIn-lEipNDVrqUqB6Q" name="Fraction intracellular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_f_cell" isDefault="1">
+            <Parameter id="WY_WlTu5Y0K50OP2vi60gA" name="Fraction intracellular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_f_cell" isDefault="1">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" max="1" flag="62" seq="61" ref="0" bb="32" group="64" />
             </Parameter>
-            <Parameter id="lS3-ZsRkFUOUZKdxG0IQzw" name="Blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_lng" isDefault="1" displayUnit="l/min">
+            <Parameter id="BLhm1tZ8AkapKAlJ1XzHSw" name="Blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_Q_lng" isDefault="1" displayUnit="l/min">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" flag="62" seq="150" ref="0" bb="32" group="5" />
             </Parameter>
-            <Parameter id="SLZ31fsNckKS370UpGut6w" name="Density (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
+            <Parameter id="iyfBHrkhqUW8N6wDEzqoOg" name="Density (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" flag="38" seq="1" ref="0" bb="32" group="21" />
             </Parameter>
-            <Parameter id="Hh2PomLbCUi_A6N2iHs3eQ" name="Fluid recirculation flow proportionality factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.01">
+            <Parameter id="MWXOBf9h0kK-CEBbxKCcpA" name="Fluid recirculation flow proportionality factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.01">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" flag="54" seq="1" ref="0" bb="32" group="27" />
             </Parameter>
-            <Parameter id="2JlamDC7xkSKZ-iiNNI7sw" name="Lymph flow proportionality factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="3.56E-05">
+            <Parameter id="IQRWPxINYEq6iYHWFo35-w" name="Lymph flow proportionality factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="3.56E-05">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" flag="54" seq="1" ref="0" bb="32" group="58" />
             </Parameter>
-            <Parameter id="pKMiltwG_E6AGY6vClD5_Q" name="Organ volume mouse" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0001" displayUnit="l">
+            <Parameter id="ejUZcRhOvkOALxcgH5C4uw" name="Organ volume mouse" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0001" displayUnit="l">
               <Tags>
                 <Tag value="TissueOrgan" />
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               <Info min="0" flag="54" seq="1" ref="0" bb="32" group="65" />
             </Parameter>
-            <Parameter id="_WYsILEJ_UCJTpFwuHxHvA" name="Allometric scale factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.75">
+            <Parameter id="oGDO_qUs9E-d-S75OLWjvQ" name="Allometric scale factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.75">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0.75" max="0.75" flag="54" seq="1" ref="0" bb="32" group="2" />
             </Parameter>
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+            <Parameter id="DxSLGAkzpkyAB5NfKZTtxg" name="Fraction of blood for sampling" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" max="1" flag="54" seq="1" ref="0" bb="32" group="94" />
             </Parameter>
-            <Parameter id="so37hXxReEKh6lWTEMI6ug" name="Hydraulic conductivity" icon="Parameter" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="5.66666666666667E-12" displayUnit="ml/min/N">
+            <Parameter id="og3oZkjFlE6l-JlhsCatyg" name="Flow fraction via large pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.05">
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+              <Info min="0" max="1" flag="122" seq="18" ref="0" bb="32" group="114" />
             </Parameter>
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+            <Parameter id="PVO3fYjrWUKmXGpQ2FG8qA" name="Hydraulic conductivity" icon="Parameter" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="5.66666666666667E-12" displayUnit="ml/min/N">
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+              <Info min="0" flag="122" seq="18" ref="0" bb="32" group="115" />
             </Parameter>
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+            <Parameter id="VPFhvOAX7UaOodb-gr0gxQ" name="Radius (large pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.5E-07" displayUnit="µm">
               <Tags>
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+              <Info min="0" flag="122" seq="18" ref="0" bb="32" group="55" />
             </Parameter>
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+            <Parameter id="PKTPC4LHWEWX5lnBhyL1pQ" name="Radius (small pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="4.5E-08" displayUnit="µm">
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+              <Info min="0" flag="122" seq="18" ref="0" bb="32" group="99" />
             </Parameter>
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+            <Parameter id="W1VM6c_IZ0aXzk0ooeIc9g" name="Vf (lipid)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.01">
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+            <Parameter id="RGDhleCDVESxvGcMV1GfPQ" name="Vf (neutral lipid)-PT" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.003">
               <Tags>
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-              </Tags>
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-            </Parameter>
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+            <Parameter id="RoSjCTSYT0iuthGbovP9Zg" name="Vf (phospholipid)-PT" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.009">
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+            <Parameter id="HbdiHSfugkuWUaPa4I1mEw" name="Vf (protein)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.183">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
-              <Info min="0" max="1" flag="122" seq="56" ref="0" bb="32" group="86" />
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-                <Parameter id="E5fVS21s_k-OgXE6eplLdg" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" isDefault="1" displayUnit="l">
+                <Parameter id="UNdJxFmaxE28WhOoPdsD7Q" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" isDefault="1" displayUnit="l">
                   <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                   <Info min="0" flag="62" seq="18" ref="0" bb="2" group="121" />
                 </Parameter>
-                <Container id="LxBDrQdi9kyhJfOjxqDOjA" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="q4beDt3IukqQl_fED0IESw" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                   <Children>
-                    <Parameter id="0rw17KWB0kuOsyDE4Naeyw" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                    <Parameter id="ebOjhLlpXU-BjCaIKnCDkg" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                     </Parameter>
-                    <Parameter id="18cRU3jHbkuGiuAKdI6boA" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" isDefault="1">
+                    <Parameter id="14DW9chKjEGlqFr02SUS3g" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                     </Parameter>
-                    <Parameter id="CsVqkDdKFUizxLpTNhY0lA" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
+                    <Parameter id="4shlQxP7U0Cs-mLDHJgNjw" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
                       <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                     </Parameter>
                   </Children>
                 </Container>
               </Children>
             </Container>
-            <Container id="T8kS11TneUyMD8yKa4Wggg" name="Interstitial" mode="Physical" containerType="Compartment">
+            <Container id="ETTLvMWN20SCaw0SGm1bKg" name="Interstitial" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="Lung" />
               </Tags>
               <Children>
-                <Parameter id="baNZvJbypEya1NTebiUgkg" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                <Parameter id="AS-WPG4crU2YfdApJcBrAQ" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
                   <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                 </Parameter>
-                <Parameter id="x10xfv1H9EeOaBZC6mOE6A" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" isDefault="1" displayUnit="l">
+                <Parameter id="6r4G8CH1HkaeMmPDbviU-w" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" isDefault="1" displayUnit="l">
                   <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                   <Info min="0" flag="62" seq="18" ref="0" bb="2" group="124" />
                 </Parameter>
-                <Parameter id="WZrZk9w4yUWA3hY7JBxSJQ" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_pH_INT" isDefault="1">
+                <Parameter id="vQaMsPZWz0GDVMEFW7AQXw" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_pH_INT" isDefault="1">
                   <Tags>
                     <Tag value="Lung" />
                   </Tags>
                   <Info min="0" max="14" flag="122" seq="56" ref="0" bb="32" group="84" />
                 </Parameter>
-                <Container id="AoXAhnq1t06iXSyKaigd3Q" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="LRQvXFxSu069cuYt_p3nfQ" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                   <Children>
-                    <Parameter id="93tZqJaOk0iLpt0sLEU03A" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                    <Parameter id="DWaaCty_5E-lBpUUJ99aPw" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                     </Parameter>
-                    <Parameter id="5xUK03dGbk2TXFMRQXtpTQ" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_lng" isDefault="1">
+                    <Parameter id="rY_hoZ-Ix0Sswgeus4eMfw" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_lng" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                     </Parameter>
-                    <Parameter id="yonf-QRPG06j6iKY_YI4Hw" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
+                    <Parameter id="u5lpPXJw606mp4VOAAj85w" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
                       <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                     </Parameter>
                   </Children>
                 </Container>
               </Children>
             </Container>
-            <Container id="6tQ3Gid3d0K9sD5HFOTSCQ" name="Intracellular" mode="Physical" containerType="Compartment">
+            <Container id="PLDYPc-pA0CXf1lrZtBM0A" name="Intracellular" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="Lung" />
               </Tags>
               <Children>
-                <Parameter id="sxQmk23hKEC6uEhpt8jpFA" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" isDefault="1" displayUnit="l">
+                <Parameter id="qLx6i7daV0SlHcV_sf5enA" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" isDefault="1" displayUnit="l">
                   <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                 </Parameter>
-                <Parameter id="rIedv-mqmkaJqJ_YxC_ovw" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" isDefault="1" displayUnit="l">
+                <Parameter id="ai5mB5k4kUWWFUxlYTg7-A" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" isDefault="1" displayUnit="l">
                   <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                   <Info min="0" flag="62" seq="18" ref="0" bb="2" group="125" />
                 </Parameter>
-                <Parameter id="6V-mEZR_iUeVtEI4Gwh_NQ" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="6.6">
+                <Parameter id="DqAsqOE_c0KM9JnFEIQL1A" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="6.6">
                   <Tags>
                     <Tag value="Lung" />
                   </Tags>
                   <ValueOrigin id="34" source="Publication" description="Toxicol In Vitro. 2008 Mar;22(2):457-67 https://doi.org/10.1016/j.tiv.2007.09.010" />
                   <Info min="0" max="14" flag="122" seq="57" ref="0" bb="32" group="83" />
                 </Parameter>
-                <Container id="-6Uq5ZsjckuPRmZ562Vokg" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="McxP3N4S-ku1eaTFBT2s8g" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                   <Children>
-                    <Parameter id="-tj17Jk_F0yQo07b6_CSnA" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                    <Parameter id="gi6CAXPPxkiyKdhMIMEulg" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                     </Parameter>
-                    <Parameter id="i79TZRneo0K12hlmEWahsw" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_lng" isDefault="1">
+                    <Parameter id="KdeuqJrJRUOufAu41UILVA" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_lng" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                     </Parameter>
-                    <Parameter id="5qmpw4zaWU-TuRdcY0e0Uw" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
+                    <Parameter id="g0n5nk3DoEKve4GzIdRQTQ" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
                       <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                     </Parameter>
                   </Children>
@@ -12014,214 +12077,215 @@
             </Container>
           </Children>
         </Container>
-        <Container id="2VcQ9uPhjEev6oXFuNrqHg" name="Muscle" mode="Logical" containerType="Organ">
+        <Container id="j4RRGFuI-kKJkSQ2d50B5Q" name="Muscle" mode="Logical" containerType="Organ">
           <Tags>
             <Tag value="TissueOrgan" />
           </Tags>
           <Children>
-            <Parameter id="TKS6KR_N00WHbu62Ab-Rkg" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
+            <Parameter id="Zn6_rYIpVEePsK8cfdeCoQ" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
             </Parameter>
-            <Parameter id="ca0pkOb6mkSLQ57W5W4KuA" name="Fluid recirculation flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate" isDefault="1" displayUnit="l/min">
+            <Parameter id="RYAcslV_H0aZwDmrl-ZDvg" name="Fluid recirculation flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate" isDefault="1" displayUnit="l/min">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
               <Info min="0" flag="122" seq="19" ref="0" bb="32" group="27" />
             </Parameter>
-            <Parameter id="vdHNOckIakKnA9zgnZbH5Q" name="Volume (endothelium)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="VascularEndoVolume.VOLUME_VascularEndo_mus" isDefault="1" displayUnit="l">
+            <Parameter id="zZR-Vqn4o0mfzip_CsLP0A" name="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Lymph_flow_rate" isDefault="1" displayUnit="l/min">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
-              <Info min="0" flag="62" seq="19" ref="0" bb="32" group="127" />
+              <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+              <Info min="0" flag="122" seq="19" ref="0" bb="32" group="58" />
             </Parameter>
-            <Parameter id="JtJ15Apl6UKZGCyNlxnc1Q" name="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Lymph_flow_rate" isDefault="1" displayUnit="l/min">
+            <Parameter id="MJ6JU_wtuUW-EDHg5H8bkg" name="Volume (endothelium)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="VascularEndoVolume.VOLUME_VascularEndo_mus" isDefault="1" displayUnit="l">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
-              <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-              <Info min="0" flag="122" seq="19" ref="0" bb="32" group="58" />
+              <Info min="0" flag="62" seq="19" ref="0" bb="32" group="127" />
             </Parameter>
-            <Parameter id="Qa9XL2ti-UWiLJ5ZTqeJ_A" name="Fraction intracellular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_f_cell" isDefault="1">
+            <Parameter id="IPgr5X9P9kCZL6UnGlBwYw" name="Fraction intracellular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_f_cell" isDefault="1">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" max="1" flag="62" seq="64" ref="0" bb="32" group="64" />
             </Parameter>
-            <Parameter id="i5r44MzvMECKv8e3A-etiQ" name="Blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_from_Qspec" isDefault="1" displayUnit="l/min">
+            <Parameter id="XtyjjmjydkmE7x6lE-Bxxw" name="Blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_from_Qspec" isDefault="1" displayUnit="l/min">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
-              <ValueOrigin id="48" description="TODO: Absolute from specific calculation" />
+              <ValueOrigin id="48" source="Other" description="Absolute value = specific value (i.e. value normalized to the volume of the organ) multiplied by the organ volume" />
               <Info min="0" flag="62" seq="162" ref="0" bb="32" group="5" />
             </Parameter>
-            <Parameter id="mSHjz53VKkSoht-lcLhLng" name="Lymph flow proportionality factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.00201">
+            <Parameter id="bcUxXwcnS0O3E80pXXmBsw" name="Density (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
-              <Info min="0" flag="54" seq="1" ref="0" bb="32" group="58" />
+              <Info min="0" flag="38" seq="1" ref="0" bb="32" group="21" />
             </Parameter>
-            <Parameter id="z8MqGMd4AEK_PU37Q6nROg" name="Fluid recirculation flow proportionality factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.292">
+            <Parameter id="wKZY69P7EUe3OqtkNBSBNg" name="Fluid recirculation flow proportionality factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.292">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" flag="54" seq="1" ref="0" bb="32" group="27" />
             </Parameter>
-            <Parameter id="kuq8g587MkSjsHtUBLY_tw" name="Organ volume mouse" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.01" displayUnit="l">
+            <Parameter id="fB3DcRR2hkq6ePhhN0vLmQ" name="Lymph flow proportionality factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.00201">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
-              <Info min="0" flag="54" seq="1" ref="0" bb="32" group="65" />
+              <Info min="0" flag="54" seq="1" ref="0" bb="32" group="58" />
             </Parameter>
-            <Parameter id="2Xnlkr6i4UigBzqvqcrcNw" name="Peripheral blood flow fraction" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.287">
+            <Parameter id="FvkqTYdRlUiNU57hgWaMfQ" name="Organ volume mouse" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.01" displayUnit="l">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
-              <ValueOrigin id="46" source="Publication" description="Thiel C, Schneckener S, Krauss M, Ghallab A, Hofmann U, et al. A systematic evaluation of the use of physiologically based pharmacokinetic modeling for cross-species extrapolation. J Pharm Sci. 2015 Jan;104(1):191-206 https://doi.org/10.1002/jps.24214" />
-              <Info min="0" max="1" flag="122" seq="1" ref="0" bb="32" group="74" />
+              <Info min="0" flag="54" seq="1" ref="0" bb="32" group="65" />
             </Parameter>
-            <Parameter id="E6SvH2qOqkO7jtRIFhQ2Jw" name="Density (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
+            <Parameter id="XLfEIKbUREGe7Uobj10JiA" name="Peripheral blood flow fraction" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.287">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
-              <Info min="0" flag="38" seq="1" ref="0" bb="32" group="21" />
+              <ValueOrigin id="46" source="Publication" description="Thiel C, Schneckener S, Krauss M, Ghallab A, Hofmann U, et al. A systematic evaluation of the use of physiologically based pharmacokinetic modeling for cross-species extrapolation. J Pharm Sci. 2015 Jan;104(1):191-206 https://doi.org/10.1002/jps.24214" />
+              <Info min="0" max="1" flag="122" seq="1" ref="0" bb="32" group="74" />
             </Parameter>
-            <Parameter id="FLSpDmSXqUOZSkaj23u5dA" name="Allometric scale factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2">
+            <Parameter id="4rxiDHrTAEubL1CVlb-QOg" name="Allometric scale factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="2" max="2" flag="54" seq="1" ref="0" bb="32" group="2" />
             </Parameter>
-            <Parameter id="L0iUSmFNLkG_OQxcn985OA" name="Fraction of blood for sampling" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+            <Parameter id="jEXFqEhob0So5wCtGXTCKg" name="Fraction of blood for sampling" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" max="1" flag="54" seq="1" ref="0" bb="32" group="94" />
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+                <Parameter id="b77sbt4Bw0i3jAi1HKMP2g" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.76">
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@@ -12274,40 +12338,27 @@
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+            <DistributedParameter id="KfSWrl2DVUOXu8sSceMsSQ" name="Fraction interstitial" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="I_BD7kmqH0qbqIwEscx2bw" mode="Logical" isDefault="1">
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+                <Parameter id="yCUV91S-xE6Qz5U9z8He5A" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
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+                <Parameter id="_lqtp9V7AE-0kGP6AVF3Nw" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.16">
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                 </Parameter>
               </Children>
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
+              <ValueOrigin id="40" source="Publication" description="Edginton, A.N., Schmitt, W. &amp; Willmann, S. Clin Pharmacokinet (2006) 45: 1013. https://doi.org/10.2165/00003088-200645100-00005" />
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-              <Children>
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-                <Parameter id="_hTfVSrrikmd3C1rrCvDNQ" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0049">
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-                <Tag value="TissueOrgan" />
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+            <DistributedParameter id="XJhvHqfE-UOhIiVt1qMv2Q" name="Vf (neutral lipid)-RR" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="KB3ts-bY502GcHEq6udWOw" mode="Logical" isDefault="1">
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-                <Parameter id="Sf5qHwOjTkqYhHgLFQterA" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                <Parameter id="X0JeDVdd50qibpvORnf4WA" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
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                 </Parameter>
-                <Parameter id="YQz79xT7gUWnVWKl2VIBnw" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.022">
+                <Parameter id="ZtVvrY02iUeOzSiXHjyL2A" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.022">
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@@ -12317,26 +12368,26 @@
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+            <DistributedParameter id="2Me19dXmfE2DBOxLh8-JRw" name="Vf (neutral lipid)-WS" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="l62Czzbhe0C6dhP87GYjDA" mode="Logical" isDefault="1">
               <Children>
-                <Parameter id="X-ZycyH2zE2x2c8J3Dtepg" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                <Parameter id="uStWNkmBTUOaAjPkwUXUag" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
                   <Info min="0" flag="18" seq="1" ref="0" bb="32" group="95" />
                 </Parameter>
-                <Parameter id="HYQMauzv0ky87AVZJJ5EPA" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0042">
+                <Parameter id="8S7QiJTLoUi1ZTcRUGmkvg" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0049">
                   <Info min="0" max="1" flag="50" seq="1" ref="0" bb="32" group="95" />
                 </Parameter>
               </Children>
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
-              <Info min="0" max="1" flag="122" seq="96" ref="0" bb="32" group="95" />
+              <Info min="0" max="1" flag="122" seq="95" ref="0" bb="32" group="95" />
             </DistributedParameter>
-            <DistributedParameter id="E25a-vFGFECkCEO6PTrMRQ" name="Vf (neutral phospholipid)-RR" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="WlnmrPJl3Ui28djABbWbUQ" mode="Logical" isDefault="1">
+            <DistributedParameter id="kj9miuoBZEm3-klc-zz_ug" name="Vf (neutral phospholipid)-RR" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="WB-DDI46M0O15EwDZ8f9bA" mode="Logical" isDefault="1">
               <Children>
-                <Parameter id="Z5qzxsWKUkmDlXfeODUkjQ" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                <Parameter id="Ed7THIuEDk6H6VjbXaUL6A" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
                   <Info min="0" flag="18" seq="1" ref="0" bb="32" group="92" />
                 </Parameter>
-                <Parameter id="lERpjFODXUeg2GRnYdsn0A" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0078">
+                <Parameter id="O1Kw87yKAEGHF-OmTZhudg" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0078">
                   <Info min="0" max="1" flag="50" seq="1" ref="0" bb="32" group="92" />
                 </Parameter>
               </Children>
@@ -12346,12 +12397,26 @@
               <ValueOrigin id="23" source="Publication" description="Rodgers T, Rowland M. Mechanistic approaches to volume of distribution predictions: understanding the processes. Pharm Res. 2007 May;24(5):918-33. https://doi.org/10.1007/s11095-006-9210-3" />
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             </DistributedParameter>
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+            <DistributedParameter id="We_YcWe5806jbMhYW1TwFg" name="Vf (neutral phospholipid, plasma)-WS" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="PeQKH_0f6EKv6J09aMp0Zw" mode="Logical" isDefault="1">
+              <Children>
+                <Parameter id="NvYdk6_96kK3ErA-OjZrSw" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                  <Info min="0" flag="18" seq="1" ref="0" bb="32" group="95" />
+                </Parameter>
+                <Parameter id="bJwJKAOl7UeyjEzx2fIHxw" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0042">
+                  <Info min="0" max="1" flag="50" seq="1" ref="0" bb="32" group="95" />
+                </Parameter>
+              </Children>
+              <Tags>
+                <Tag value="TissueOrgan" />
+              </Tags>
+              <Info min="0" max="1" flag="122" seq="96" ref="0" bb="32" group="95" />
+            </DistributedParameter>
+            <DistributedParameter id="7ak0vEKkxEOfmkHNDHY4Sg" name="Vf (extracellular water)-RR" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="s5w560cHfkmRoT7AGMDJdQ" mode="Logical" isDefault="1">
               <Children>
-                <Parameter id="qDlwp7QP5k62x7jCKPr6NA" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                <Parameter id="KH48FNdDjUG534HdwSC2rw" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
                   <Info min="0" flag="18" seq="1" ref="0" bb="32" group="92" />
                 </Parameter>
-                <Parameter id="CquIZbYVpUy5s7nf-uVvoQ" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.079">
+                <Parameter id="VpAJC83yckOwm1i4zMQoCg" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.079">
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                 </Parameter>
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@@ -12360,12 +12425,12 @@
               </Tags>
               <Info min="0" max="1" flag="122" seq="97" ref="0" bb="32" group="92" />
             </DistributedParameter>
-            <DistributedParameter id="pvoPbcz9bUKR5yOuACTgvg" name="Vf (protein)-WS" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="akVu42vKm0awvbCfCpn3fQ" mode="Logical" isDefault="1">
+            <DistributedParameter id="9__zhDbkVEeL0cxD7ELw8A" name="Vf (protein)-WS" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IUgxzfHOjEOw8GNnrBP3Rw" mode="Logical" isDefault="1">
               <Children>
-                <Parameter id="r3FVjr59rUyeWGh_FGIVLg" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                <Parameter id="J1a-BEM400SEPeZTIsB1GA" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
                   <Info min="0" flag="18" seq="1" ref="0" bb="32" group="95" />
                 </Parameter>
-                <Parameter id="aAT1a3DLYU69esR2rjAvMQ" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.19">
+                <Parameter id="ScSYpOCUhUGKeBFDEm27-A" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.19">
                   <Info min="0" max="1" flag="50" seq="1" ref="0" bb="32" group="95" />
                 </Parameter>
               </Children>
@@ -12374,12 +12439,12 @@
               </Tags>
               <Info min="0" max="1" flag="122" seq="97" ref="0" bb="32" group="95" />
             </DistributedParameter>
-            <DistributedParameter id="O7tcv0vA00y9qJQlrNAmMg" name="Vf (intracellular water)-RR" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="LoL6giL1EkCjdtXVzH9t7A" mode="Logical" isDefault="1">
+            <DistributedParameter id="APe7um6t8k-PfC8nQgVzTg" name="Vf (intracellular water)-RR" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="iWgAUAgHJkC498xsnun5Ig" mode="Logical" isDefault="1">
               <Children>
-                <Parameter id="kBm591SE80mGe196Ld9tTA" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                <Parameter id="syvN5aNi1k6tYw1RpoiZVA" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
                   <Info min="0" flag="18" seq="1" ref="0" bb="32" group="92" />
                 </Parameter>
-                <Parameter id="7tryDIHC4UKjIb6utAuxLQ" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.666">
+                <Parameter id="blTFaycZSkWUm0clQk4_hQ" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.666">
                   <Info min="0" max="1" flag="50" seq="1" ref="0" bb="32" group="92" />
                 </Parameter>
               </Children>
@@ -12388,12 +12453,12 @@
               </Tags>
               <Info min="0" max="1" flag="122" seq="98" ref="0" bb="32" group="92" />
             </DistributedParameter>
-            <DistributedParameter id="kkEMVPz7ak-61nMm6hZLgg" name="Vf (water)-WS" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BhagTspB5UeNHoPhqKL5xw" mode="Logical" isDefault="1">
+            <DistributedParameter id="3AyJXbz_-0-ChjXXnI0STQ" name="Vf (water)-WS" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="4TullDmhF0WHAMuhKvpcxQ" mode="Logical" isDefault="1">
               <Children>
-                <Parameter id="UdwrE_C_r0u2xveTDozNXQ" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                <Parameter id="5WKv97aS9UGlEsN78jMhxA" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
                   <Info min="0" flag="18" seq="1" ref="0" bb="32" group="95" />
                 </Parameter>
-                <Parameter id="P0zyrnDp-U2qng1SEToUpA" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.76">
+                <Parameter id="g-Wexy1E00W7EuGl62xwiA" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.76">
                   <Info min="0" max="1" flag="50" seq="1" ref="0" bb="32" group="95" />
                 </Parameter>
               </Children>
@@ -12402,138 +12467,139 @@
               </Tags>
               <Info min="0" max="1" flag="122" seq="98" ref="0" bb="32" group="95" />
             </DistributedParameter>
-            <DistributedParameter id="3wPrtscAAUW8OoiRcvxiog" name="Specific blood flow rate" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" formula="CYGWBv-_hkCFr-ClxUWLbw" mode="Logical" isDefault="1" displayUnit="ml/min/100g organ">
+            <DistributedParameter id="QE6RXW7P-k6ulBmQoQwHTA" name="Specific blood flow rate" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" formula="nHGYQ7rijkO9QxPzBakO1A" mode="Logical" isDefault="1" displayUnit="ml/min/100g organ">
               <Children>
-                <Parameter id="1v0WiOKAK0K935gMEZ35-Q" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5" displayUnit="ml/min/100g organ">
+                <Parameter id="zlGwx5pM10e0VRvIYMRH8Q" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5" displayUnit="ml/min/100g organ">
                   <Info min="0" flag="18" seq="1" ref="0" bb="32" group="5" />
                 </Parameter>
-                <Parameter id="yY8yIQ12rEO3rE4JuNEiQw" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.03419" displayUnit="ml/min/100g organ">
+                <Parameter id="KIIj7GC7EUubZ90y9V5HzQ" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.03419" displayUnit="ml/min/100g organ">
                   <Info min="0" flag="50" seq="1" ref="0" bb="32" group="5" />
                 </Parameter>
-                <Parameter id="EM4RNW64jUm0N0Pz20FFOQ" name="Deviation" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0017095" displayUnit="ml/min/100g organ">
+                <Parameter id="Zz5wB29keUu1AXsS7eUY3Q" name="Deviation" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0017095" displayUnit="ml/min/100g organ">
                   <Info min="0" flag="18" seq="1" ref="0" bb="32" group="5" />
                 </Parameter>
               </Children>
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
+              <ValueOrigin id="40" source="Publication" description="Edginton, A.N., Schmitt, W. &amp; Willmann, S. Clin Pharmacokinet (2006) 45: 1013. https://doi.org/10.2165/00003088-200645100-00005" />
               <Info min="0" flag="122" seq="161" ref="0" bb="32" group="5" />
             </DistributedParameter>
-            <Container id="2LI7MHC5ZUe9U4VNvxVI9w" name="Plasma" mode="Physical" containerType="Compartment">
+            <Container id="__53rbP1vUqN8-pa2a0EGQ" name="Plasma" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="Muscle" />
               </Tags>
               <Children>
-                <Parameter id="CqUL8bQWZE6da00yk_3uBA" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                <Parameter id="Cg5lVl7DoE62DlE5rme5fg" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
                   <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                 </Parameter>
-                <Parameter id="3OUk5lkiIEyQQoMn79Iqfw" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" isDefault="1" displayUnit="l">
+                <Parameter id="tRcht_WJSkKjB8bNX8o--Q" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" isDefault="1" displayUnit="l">
                   <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                   <Info min="0" flag="62" seq="19" ref="0" bb="2" group="126" />
                 </Parameter>
-                <Container id="p2-lt2Ph8kKluuDEUiFTZQ" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="G13zKWdOX0C-MVtli9gUww" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                   <Children>
-                    <Parameter id="ZNUwl1yz-026Vb4ovuxJXg" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                    <Parameter id="mUBbrwcSukOwdlbMK3dBUQ" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
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                     </Parameter>
-                    <Parameter id="vQ4SCP8pXkeXQfIbhvghEA" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
-                      <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
-                    </Parameter>
-                    <Parameter id="GCze-DZxZ0OzfnlSBUGH4w" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" isDefault="1">
+                    <Parameter id="MZ3JvKsFYkyH47DP80IaOA" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                     </Parameter>
+                    <Parameter id="kyeVgGh0QEip9OuJrwcl6A" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
+                      <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                    </Parameter>
                   </Children>
                 </Container>
               </Children>
             </Container>
-            <Container id="kSEHk8YXX0q_Bvhjs5u3wQ" name="BloodCells" mode="Physical" containerType="Compartment">
+            <Container id="1sOBPguOQU2A81RiIwHu2A" name="BloodCells" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="Muscle" />
               </Tags>
               <Children>
-                <Parameter id="vm6dStlGhEuzoomaLSzx8w" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                <Parameter id="Ux1KewhGZUmoSReAs6X_pQ" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
                   <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                 </Parameter>
-                <Parameter id="po7W9xOby0CaDbwDZfqAHQ" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" isDefault="1" displayUnit="l">
+                <Parameter id="tZV58Qf_AUWmSo-aif1dQQ" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" isDefault="1" displayUnit="l">
                   <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                   <Info min="0" flag="62" seq="19" ref="0" bb="2" group="121" />
                 </Parameter>
-                <Container id="-XcQ8GSQxEulx7YJF2NdKg" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="ADJGzn_c_ke06-knQ0QPKg" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                   <Children>
-                    <Parameter id="hIs6mqKkgUaPzZeREFeScw" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                    <Parameter id="xsVbAWzVZkiaZ6JuGO_O5w" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                     </Parameter>
-                    <Parameter id="bAYo8orOKEKWyZWLm6t7ZQ" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
-                      <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
-                    </Parameter>
-                    <Parameter id="foweA0aeVUiguuiTVbHNHg" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" isDefault="1">
+                    <Parameter id="AE9fSnDBt0aIvmQfgWsuZA" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                     </Parameter>
+                    <Parameter id="Xuy5XBpsPkq2a7RGhlKHxQ" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
+                      <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                    </Parameter>
                   </Children>
                 </Container>
               </Children>
             </Container>
-            <Container id="qy-phnBIJUCvFa4JVcEMnA" name="Interstitial" mode="Physical" containerType="Compartment">
+            <Container id="nxDcbYYHQEaAHwpJ5JI_wQ" name="Interstitial" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="Muscle" />
               </Tags>
               <Children>
-                <Parameter id="RXkURGE8NE25LnrlMPXMGA" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                <Parameter id="HSKO7o_dbUucukPu_rXPfw" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
                   <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                 </Parameter>
-                <Parameter id="eB6H16d6lUmpT8JDDDEZBA" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" isDefault="1" displayUnit="l">
+                <Parameter id="ce6FM0-NXE2ntGMDRp1cFw" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" isDefault="1" displayUnit="l">
                   <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                   <Info min="0" flag="62" seq="19" ref="0" bb="2" group="124" />
                 </Parameter>
-                <Parameter id="cKBM51fAK0SrSU3Zbo3bFQ" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_pH_INT" isDefault="1">
+                <Parameter id="B8eL-QgKBkaEO31llD4iGw" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_pH_INT" isDefault="1">
                   <Tags>
                     <Tag value="Muscle" />
                   </Tags>
                   <Info min="0" max="14" flag="122" seq="59" ref="0" bb="32" group="84" />
                 </Parameter>
-                <Container id="x2PvbLPF9kmDbf7GAJV35g" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="s29XXu2vEECbG7ZX-o0Rtg" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                   <Children>
-                    <Parameter id="fPusBB3wc0mwwu312KepPg" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                    <Parameter id="8d1hAqRYjEOGEEK43YKbgg" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                     </Parameter>
-                    <Parameter id="VK0cqOzjP0yj5tut4skxrQ" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_mus" isDefault="1">
+                    <Parameter id="dj0K4wDgDkGVlEtRWPv2Bg" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_mus" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                     </Parameter>
-                    <Parameter id="CJP9TLYdUUieeaHLZcnQ0Q" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
+                    <Parameter id="iQ1PfcJVDEGC-TO2LGrpKg" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
                       <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                     </Parameter>
                   </Children>
                 </Container>
               </Children>
             </Container>
-            <Container id="PA-KMkaV8EaZFpDX1F5o3A" name="Intracellular" mode="Physical" containerType="Compartment">
+            <Container id="MqthY_h2P0mzAS45ZQj5Ww" name="Intracellular" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="Muscle" />
               </Tags>
               <Children>
-                <Parameter id="PGdFgO4X506M2vaFiguPpA" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" isDefault="1" displayUnit="l">
+                <Parameter id="nCfS3gBJHEuIdJ0LkQHbeg" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" isDefault="1" displayUnit="l">
                   <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                 </Parameter>
-                <Parameter id="rSGBNSyGmUOp02skM4ljWg" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" isDefault="1" displayUnit="l">
+                <Parameter id="6nCjmJLrl0eGvKZaEj7GAw" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" isDefault="1" displayUnit="l">
                   <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                   <Info min="0" flag="62" seq="19" ref="0" bb="2" group="125" />
                 </Parameter>
-                <Parameter id="1qaiC-Ite0GLUnb_IapATw" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="6.81">
+                <Parameter id="Lc1AN01ydUm2wPF4CcS1Jw" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="6.81">
                   <Tags>
                     <Tag value="Muscle" />
                   </Tags>
                   <ValueOrigin id="34" source="Publication" description="Toxicol In Vitro. 2008 Mar;22(2):457-67 https://doi.org/10.1016/j.tiv.2007.09.010" />
                   <Info min="0" max="14" flag="122" seq="59" ref="0" bb="32" group="83" />
                 </Parameter>
-                <Container id="-FyUDTT_80SZ2I4ypMLXSA" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="aRxULDMn4EWK12GaRfZVfg" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                   <Children>
-                    <Parameter id="aOOSREFNhEy1-zRkpVm2mw" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                    <Parameter id="8r5ycluhJkWlYw8STxFYiA" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                     </Parameter>
-                    <Parameter id="HG0yD2IznUKSCxiobze2oQ" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_mus" isDefault="1">
+                    <Parameter id="IUU7uVKTj0mi1P2ZlZnksQ" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_mus" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                     </Parameter>
-                    <Parameter id="I0Z-nzal00KSInL4x0ISsA" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
+                    <Parameter id="C9vRfu-_F06vLxVnp_BO5A" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
                       <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                     </Parameter>
                   </Children>
@@ -12542,100 +12608,100 @@
             </Container>
           </Children>
         </Container>
-        <Container id="YlSy_8eFJ0yH0dZvgZ9nUA" name="Pancreas" mode="Logical" containerType="Organ">
+        <Container id="HCj9qLdWCEOA8US6gCY1Zw" name="Pancreas" mode="Logical" containerType="Organ">
           <Tags>
             <Tag value="Portal Vein Supplying Organ" />
             <Tag value="TissueOrgan" />
           </Tags>
           <Children>
-            <Parameter id="JGESBVeVQ0CNNE5nuZbfPg" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
+            <Parameter id="ys_kPAqmQEa60lLJ61miSg" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
             </Parameter>
-            <Parameter id="vf6gzWNYH06R2KOteOYGeg" name="Volume (endothelium)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="VascularEndoVolume.VOLUME_VascularEndo_pan" isDefault="1" displayUnit="l">
+            <Parameter id="NuqoWZ4HnEmjiQIYm6jmuQ" name="Fluid recirculation flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate" isDefault="1" displayUnit="l/min">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
-              <Info min="0" flag="62" seq="20" ref="0" bb="32" group="127" />
+              <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+              <Info min="0" flag="122" seq="20" ref="0" bb="32" group="27" />
             </Parameter>
-            <Parameter id="RLP_gMzmtUW8qEWu40O-kw" name="Fluid recirculation flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate" isDefault="1" displayUnit="l/min">
+            <Parameter id="zhkvsTlLHUGpu_S3oK_O_w" name="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Lymph_flow_rate" isDefault="1" displayUnit="l/min">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-              <Info min="0" flag="122" seq="20" ref="0" bb="32" group="27" />
+              <Info min="0" flag="122" seq="20" ref="0" bb="32" group="58" />
             </Parameter>
-            <Parameter id="Qstj0dXiaUul_P2y4Do4Lw" name="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Lymph_flow_rate" isDefault="1" displayUnit="l/min">
+            <Parameter id="EHB5RCY1uUKnGORZmeogvA" name="Volume (endothelium)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="VascularEndoVolume.VOLUME_VascularEndo_pan" isDefault="1" displayUnit="l">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
-              <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-              <Info min="0" flag="122" seq="20" ref="0" bb="32" group="58" />
+              <Info min="0" flag="62" seq="20" ref="0" bb="32" group="127" />
             </Parameter>
-            <Parameter id="BkUrKYcb0EqGvD0s1QpiMQ" name="Fraction intracellular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_f_cell" isDefault="1">
+            <Parameter id="e42IZs5r7UOFj9UEKQvW4Q" name="Fraction intracellular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_f_cell" isDefault="1">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" max="1" flag="62" seq="67" ref="0" bb="32" group="64" />
             </Parameter>
-            <Parameter id="Sye06klpKEqK00id5K9W7w" name="Blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_from_Qspec" isDefault="1" displayUnit="l/min">
+            <Parameter id="DCWAeczWhEiLqDpUacHV6Q" name="Blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_from_Qspec" isDefault="1" displayUnit="l/min">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
-              <ValueOrigin id="48" description="TODO: Absolute from specific calculation" />
+              <ValueOrigin id="48" source="Other" description="Absolute value = specific value (i.e. value normalized to the volume of the organ) multiplied by the organ volume" />
               <Info min="0" flag="62" seq="182" ref="0" bb="32" group="5" />
             </Parameter>
-            <Parameter id="tpmtUTSJYkivmHYL8IVnXg" name="Density (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
+            <Parameter id="VGgIuUSU10KAY0QNYLKVaw" name="Density (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" flag="38" seq="1" ref="0" bb="32" group="21" />
             </Parameter>
-            <Parameter id="m7DttoF1yEOTZfnNpyuf6A" name="Fluid recirculation flow proportionality factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.01">
+            <Parameter id="HVXICLcnkUa115wDS_FxOA" name="Fluid recirculation flow proportionality factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.01">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" flag="54" seq="1" ref="0" bb="32" group="27" />
             </Parameter>
-            <Parameter id="cxnPrk_4NUSDqiFgGpy-hg" name="Lymph flow proportionality factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0303">
+            <Parameter id="KpF-eUTD_kGSER0vv3LFNQ" name="Lymph flow proportionality factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0303">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" flag="54" seq="1" ref="0" bb="32" group="58" />
             </Parameter>
-            <Parameter id="J7_Kd885yES__M0APmVoIA" name="Organ volume mouse" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.00013" displayUnit="l">
+            <Parameter id="BqL_yDfeG0KCn2GUU8yKwQ" name="Organ volume mouse" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.00013" displayUnit="l">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" flag="54" seq="1" ref="0" bb="32" group="65" />
             </Parameter>
-            <Parameter id="hishcYYFRk2tNksuFYFINw" name="Allometric scale factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.75">
+            <Parameter id="yUy6ste34U-8l2vpcPkQ0w" name="Allometric scale factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.75">
               <Tags>
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                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
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                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                     </Parameter>
-                    <Parameter id="UGpH4DKcWEGkknv8MxBcrg" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
+                    <Parameter id="DuW-_gRfxkqmJ9L_lWCSDQ" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
                       <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                     </Parameter>
                   </Children>
@@ -12991,115 +13059,116 @@
             </Container>
           </Children>
         </Container>
-        <Container id="vB5m2SY0dki-anBMj8IP6g" name="PortalVein" mode="Logical" containerType="Organ">
+        <Container id="-9Tm8XQvXUmBqWQhWBSJ-A" name="PortalVein" mode="Logical" containerType="Organ">
           <Tags>
             <Tag value="BloodOrgan" />
           </Tags>
           <Children>
-            <Parameter id="DHTGcFF8B0-z0uroR9gQTQ" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
+            <Parameter id="dzjkQ6d48UCCXzLzMzjN4Q" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
               <Tags>
                 <Tag value="BloodOrgan" />
               </Tags>
               <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
             </Parameter>
-            <Parameter id="wuKVTG5wf0KVc8vyTe7CDQ" name="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_Lymph_pve" isDefault="1" displayUnit="l/min">
+            <Parameter id="lZ56WWY8K0eSkMRwkeh-yw" name="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_Lymph_pve" isDefault="1" displayUnit="l/min">
               <Tags>
                 <Tag value="BloodOrgan" />
               </Tags>
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
               <Info min="0" flag="62" seq="22" ref="0" bb="32" group="58" />
             </Parameter>
-            <Parameter id="vtuxzJjzw0e-EEWTNTwguQ" name="Blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_pve" isDefault="1" displayUnit="l/min">
+            <Parameter id="rxiABHv_eEW8eUbFzKRR5A" name="Blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_pve" isDefault="1" displayUnit="l/min">
               <Tags>
                 <Tag value="BloodOrgan" />
               </Tags>
               <Info min="0" flag="62" seq="190" ref="0" bb="32" group="5" />
             </Parameter>
-            <Parameter id="f2UshLz9X0CR_FMi6KizcA" name="Density (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
+            <Parameter id="e5-ReA-kj02mn0GqtKG88w" name="Density (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
               <Tags>
                 <Tag value="BloodOrgan" />
               </Tags>
               <Info min="0" flag="38" seq="1" ref="0" bb="32" group="21" />
             </Parameter>
-            <Parameter id="aazWfHCuQkKEaSFFY_6OmQ" name="Allometric scale factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.75">
+            <Parameter id="9NusILydtU2gmsFeMNDIgg" name="Allometric scale factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.75">
               <Tags>
                 <Tag value="BloodOrgan" />
               </Tags>
               <Info min="0.75" max="0.75" flag="52" seq="1" ref="0" bb="32" group="2" />
             </Parameter>
-            <Parameter id="Am_WPlye6kKpdR5TLlfE7A" name="Fraction vascular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+            <Parameter id="iS5oNX0vB0ml-1v5nGzafQ" name="Fraction vascular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
               <Tags>
                 <Tag value="BloodOrgan" />
               </Tags>
               <Info min="0" max="1" flag="62" seq="69" ref="0" bb="32" group="64" />
             </Parameter>
-            <DistributedParameter id="TeTAxENW1EevaFY818w2gA" name="Volume" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="U2Rue_V_pE-3LNsSAORIzg" mode="Logical" isDefault="1" displayUnit="l">
+            <DistributedParameter id="kwc92RLPCkWnVhzFE2GozQ" name="Volume" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="zwnI8wyQcki3_651Q0hVug" mode="Logical" isDefault="1" displayUnit="l">
               <Children>
-                <Parameter id="_2x5mDcIQUSYizWbPa-PXg" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.501204365708457" displayUnit="l">
+                <Parameter id="1KpuyGHGPE61bwdk0yBpDA" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.501243764883788" displayUnit="l">
                   <Info min="0" flag="18" seq="1" ref="0" bb="32" group="65" />
                 </Parameter>
-                <Parameter id="Esf6PAR71U2lZ3u1PQNtEg" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.83561581977504" displayUnit="l">
+                <Parameter id="5se-Rhqdk0iTsUba8njsVg" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.0372237776" displayUnit="l">
                   <Info min="0" flag="34" seq="1" ref="0" bb="32" group="65" />
                 </Parameter>
-                <Parameter id="xjpTYGnLxEiGrMIdC-ixPA" name="Deviation" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.041780790988752" displayUnit="l">
+                <Parameter id="f_O2ajOf3UiK9vNUwjeqMg" name="Deviation" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.05186118888" displayUnit="l">
                   <Info min="0" flag="18" seq="1" ref="0" bb="32" group="65" />
                 </Parameter>
               </Children>
               <Tags>
                 <Tag value="BloodOrgan" />
               </Tags>
+              <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
               <Info min="0" flag="106" seq="13" ref="0" bb="32" group="65" />
             </DistributedParameter>
-            <Container id="meWL4gPZR0uFouhVl8UsOw" name="Plasma" mode="Physical" containerType="Compartment">
+            <Container id="vihskj6fJkaqqVik0r1DIg" name="Plasma" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="BloodOrgan" />
                 <Tag value="PortalVein" />
               </Tags>
               <Children>
-                <Parameter id="ls6_cS2b6k6nWRLijwyitA" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                <Parameter id="nsLtsf5fJkGQ-AYsEWJL_Q" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
                   <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                 </Parameter>
-                <Parameter id="fhg9jw3G00yH7qOF8iXx9A" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_pls_BloodOrgan_4Comp" isDefault="1" displayUnit="l">
+                <Parameter id="H9zZp-7Qgkea9xEVFadydA" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_pls_BloodOrgan_4Comp" isDefault="1" displayUnit="l">
                   <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                   <Info min="0" flag="62" seq="22" ref="0" bb="2" group="126" />
                 </Parameter>
-                <Container id="4H2XttD5FEG7Rq96M46TQA" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="6zE4jTTvpkeIYBvDKW1H1w" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                   <Children>
-                    <Parameter id="ifpFZZ009kOBIMmWE03q1w" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                    <Parameter id="EorCz8E39U6dQf7Ut_O4qg" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                     </Parameter>
-                    <Parameter id="kjDVylSb-UasPYgheXNqGA" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" isDefault="1">
+                    <Parameter id="_wIw-pmf20aKEUk5_T7Ndw" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                     </Parameter>
-                    <Parameter id="iofyWkFK_kKafODVwFPBnw" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
+                    <Parameter id="EKKoZdC65UioYHATKtv_pw" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
                       <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                     </Parameter>
                   </Children>
                 </Container>
               </Children>
             </Container>
-            <Container id="-ce4W1W9u0-sDuce1ufJ_A" name="BloodCells" mode="Physical" containerType="Compartment">
+            <Container id="eN7tQLMOREG3-_sYJSczng" name="BloodCells" mode="Physical" containerType="Compartment">
               <Tags>
                 <Tag value="BloodOrgan" />
                 <Tag value="PortalVein" />
               </Tags>
               <Children>
-                <Parameter id="3s32Ly8RTku43xyNx73j7A" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
+                <Parameter id="edKBA6quzU66QHxcVqEasw" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
                   <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
                 </Parameter>
-                <Parameter id="QXci0er5tUCimMTYVQ9MPg" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_bc_blood_organ_4comp" isDefault="1" displayUnit="l">
+                <Parameter id="d3LpQsMAxE6chIfrzXxARg" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_bc_blood_organ_4comp" isDefault="1" displayUnit="l">
                   <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                   <Info min="0" flag="62" seq="22" ref="0" bb="2" group="121" />
                 </Parameter>
-                <Container id="Lq-URULQgkamTDDHJDoMZQ" name="MoleculeProperties" mode="Logical" containerType="Molecule">
+                <Container id="fzROVrW2kEy3RmWKqG0J6w" name="MoleculeProperties" mode="Logical" containerType="Molecule">
                   <Children>
-                    <Parameter id="Cewe5aROP0ej8UooiUcsjQ" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
+                    <Parameter id="eczYSTl7l0WIdM1bNtPEXA" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
                     </Parameter>
-                    <Parameter id="Ej2dAmH46kmAM2FEiKdqTQ" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" isDefault="1">
+                    <Parameter id="nysVMfrdU0-p6hVAMGN7tw" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" isDefault="1">
                       <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
                     </Parameter>
-                    <Parameter id="uvLVBBVTQk6G7Q6pdcpzyw" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
+                    <Parameter id="bWUVMeH9QU2UbaaJd1aslw" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
                       <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                     </Parameter>
                   </Children>
@@ -13108,409 +13177,411 @@
             </Container>
           </Children>
         </Container>
-        <Container id="lqGPeK79n0qAp-FyWSJdew" name="Skin" mode="Logical" containerType="Organ">
+        <Container id="nFelsd_AdU66eS3JbKfNYw" name="Skin" mode="Logical" containerType="Organ">
           <Tags>
             <Tag value="TissueOrgan" />
           </Tags>
           <Children>
-            <Parameter id="d4WCeasPzk-ckw9ynuSQKQ" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
+            <Parameter id="dcgoYVla2UOLaYhyQyinzA" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
             </Parameter>
-            <Parameter id="JIa-0CjD9EOB6_PhwO1ROw" name="Fluid recirculation flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate" isDefault="1" displayUnit="l/min">
+            <Parameter id="LvFi5ShIb0u0HOuUkrKcTA" name="Fluid recirculation flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate" isDefault="1" displayUnit="l/min">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
               <Info min="0" flag="122" seq="23" ref="0" bb="32" group="27" />
             </Parameter>
-            <Parameter id="F-b0UlAWTEWDwxFOuPE90w" name="Volume (endothelium)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="VascularEndoVolume.VOLUME_VascularEndo_skn" isDefault="1" displayUnit="l">
+            <Parameter id="SODhWlSuFU-TUyeJNTP5FQ" name="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Lymph_flow_rate" isDefault="1" displayUnit="l/min">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
-              <Info min="0" flag="62" seq="23" ref="0" bb="32" group="127" />
+              <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+              <Info min="0" flag="122" seq="23" ref="0" bb="32" group="58" />
             </Parameter>
-            <Parameter id="xJJlUOikKkC3WExnu9drSA" name="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Lymph_flow_rate" isDefault="1" displayUnit="l/min">
+            <Parameter id="7RFdYZMp00WTWTMH2F8wyQ" name="Volume (endothelium)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="VascularEndoVolume.VOLUME_VascularEndo_skn" isDefault="1" displayUnit="l">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
-              <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-              <Info min="0" flag="122" seq="23" ref="0" bb="32" group="58" />
+              <Info min="0" flag="62" seq="23" ref="0" bb="32" group="127" />
             </Parameter>
-            <Parameter id="tCGtY_NbGkCFBnkO797s0Q" name="Fraction intracellular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_f_cell" isDefault="1">
+            <Parameter id="rPZtBf6WhEmUptZKmNf3sA" name="Fraction intracellular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_f_cell" isDefault="1">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" max="1" flag="62" seq="71" ref="0" bb="32" group="64" />
             </Parameter>
-            <Parameter id="PL8RgaDhWU6r1-VG6O4W5Q" name="Blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_from_Qspec" isDefault="1" displayUnit="l/min">
+            <Parameter id="QC4Ak1rvrkqOYArJCrfm1w" name="Blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_from_Qspec" isDefault="1" displayUnit="l/min">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
-              <ValueOrigin id="48" description="TODO: Absolute from specific calculation" />
+              <ValueOrigin id="48" source="Other" description="Absolute value = specific value (i.e. value normalized to the volume of the organ) multiplied by the organ volume" />
               <Info min="0" flag="62" seq="202" ref="0" bb="32" group="5" />
             </Parameter>
-            <Parameter id="ZijSWmPREUOaNmTv726spw" name="Density (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
+            <Parameter id="HtDvQxDnSUugoQeI91ciug" name="Density (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" flag="38" seq="1" ref="0" bb="32" group="21" />
             </Parameter>
-            <Parameter id="JQdKm0NP8EWzxhLzoUaYug" name="Fluid recirculation flow proportionality factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.617">
+            <Parameter id="P_2P535Dw02bXV_OE3ZXYQ" name="Fluid recirculation flow proportionality factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.617">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" flag="54" seq="1" ref="0" bb="32" group="27" />
             </Parameter>
-            <Parameter id="cTUa4Yl22UesWvIrHlmU8Q" name="Lymph flow proportionality factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.00352">
+            <Parameter id="Sqe-d7vQhEa1ITD3KmFokQ" name="Lymph flow proportionality factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.00352">
               <Tags>
                 <Tag value="TissueOrgan" />
               </Tags>
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+                    <Parameter id="xdq0n5D36EmEVdp6KYGjow" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
                       <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
                     </Parameter>
                   </Children>
@@ -13519,20 +13590,20 @@
             </Container>
           </Children>
         </Container>
-        <Container id="gYV0Ng3cOUa0___fInkNGg" name="Spleen" mode="Logical" containerType="Organ">
+        <Container id="uWtIRX1aSEOztctNnmciuA" name="Spleen" mode="Logical" containerType="Organ">
           <Tags>
             <Tag value="Portal Vein Supplying Organ" />
             <Tag value="TissueOrgan" />
           </Tags>
           <Children>
-            <Parameter id="6tNBd3p8IkmXKn8GwhtpNA" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
+            <Parameter id="EtKxULFjpEOGt4JzmpCdLw" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
             </Parameter>
-            <Parameter id="UtLCFcmCPEuL5evU0aC4Cg" name="Fluid recirculation flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate" isDefault="1" displayUnit="l/min">
+            <Parameter id="CNp-HYqwoEuZ4BInmYesGw" name="Fluid recirculation flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate" isDefault="1" displayUnit="l/min">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
@@ -13540,7 +13611,7 @@
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
               <Info min="0" flag="122" seq="24" ref="0" bb="32" group="27" />
             </Parameter>
-            <Parameter id="tWiQE2hbukKtrFhjAaiMQQ" name="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Lymph_flow_rate" isDefault="1" displayUnit="l/min">
+            <Parameter id="f2pozJ4TAkCZt7RvVm-LfA" name="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Lymph_flow_rate" isDefault="1" displayUnit="l/min">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
@@ -13548,103 +13619,103 @@
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
               <Info min="0" flag="122" seq="24" ref="0" bb="32" group="58" />
             </Parameter>
-            <Parameter id="SRPg0s842k-o6fdGpKPVCQ" name="Volume (endothelium)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="VascularEndoVolume.VOLUME_VascularEndo_spl" isDefault="1" displayUnit="l">
+            <Parameter id="1D1JM7jaLkuYi5pLg3An8Q" name="Volume (endothelium)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="VascularEndoVolume.VOLUME_VascularEndo_spl" isDefault="1" displayUnit="l">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" flag="62" seq="24" ref="0" bb="32" group="127" />
             </Parameter>
-            <Parameter id="JUkDDXHu_EGD0ZRiw_15LA" name="Fraction intracellular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_f_cell" isDefault="1">
+            <Parameter id="K8OoX0YvpE-XUr-vKSWijA" name="Fraction intracellular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_f_cell" isDefault="1">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" max="1" flag="62" seq="74" ref="0" bb="32" group="64" />
             </Parameter>
-            <Parameter id="JGrmH-pgyE6lbCjvePx8lw" name="Blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_from_Qspec" isDefault="1" displayUnit="l/min">
+            <Parameter id="oLj4LwvY90WiztuLTx2fJw" name="Blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Q_from_Qspec" isDefault="1" displayUnit="l/min">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
-              <ValueOrigin id="48" description="TODO: Absolute from specific calculation" />
+              <ValueOrigin id="48" source="Other" description="Absolute value = specific value (i.e. value normalized to the volume of the organ) multiplied by the organ volume" />
               <Info min="0" flag="62" seq="242" ref="0" bb="32" group="5" />
             </Parameter>
-            <Parameter id="9TUYn95vt02RZBxlVbdMvA" name="Density (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
+            <Parameter id="QmO2xSvDh0q6OOoD9_UeKQ" name="Density (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" flag="38" seq="1" ref="0" bb="32" group="21" />
             </Parameter>
-            <Parameter id="a-zXXFwwt0K74kbYjdWjpg" name="Fluid recirculation flow proportionality factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.01">
+            <Parameter id="5LnrUciu9UOE5DH4lukh9w" name="Fluid recirculation flow proportionality factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.01">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" flag="54" seq="1" ref="0" bb="32" group="27" />
             </Parameter>
-            <Parameter id="zW7RYfTCck2kTczSQ4oU9A" name="Lymph flow proportionality factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0199">
+            <Parameter id="mMI3N0-Z50aOAWDU9Q6XLA" name="Lymph flow proportionality factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0199">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" flag="54" seq="1" ref="0" bb="32" group="58" />
             </Parameter>
-            <Parameter id="TEM5cd6h60WulU9aRUF40Q" name="Organ volume mouse" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0001" displayUnit="l">
+            <Parameter id="yxVL1vjhBEO6cIhVU8Zefw" name="Organ volume mouse" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0001" displayUnit="l">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" flag="54" seq="1" ref="0" bb="32" group="65" />
             </Parameter>
-            <Parameter id="AoBPTqLc20KLy2k_41IDgA" name="Allometric scale factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.75">
+            <Parameter id="HTfh0c3eI0agxCJIgBqV1g" name="Allometric scale factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.75">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0.75" max="0.75" flag="54" seq="1" ref="0" bb="32" group="2" />
             </Parameter>
-            <Parameter id="_pf6md4O4EGaVTZ0I55hyg" name="Fraction of blood for sampling" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+            <Parameter id="BEvYDeeM4UWk0GdWkYlnqA" name="Fraction of blood for sampling" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" max="1" flag="54" seq="1" ref="0" bb="32" group="94" />
             </Parameter>
-            <Parameter id="QdW31ivB6kGGfPtgkcxq3w" name="Hydraulic conductivity" icon="Parameter" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="3.88888888888889E-11" displayUnit="ml/min/N">
+            <Parameter id="PRbClTa0eUmTcfkYn3H-zw" name="Flow fraction via large pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.8">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-              <Info min="0" flag="122" seq="24" ref="0" bb="32" group="115" />
+              <Info min="0" max="1" flag="122" seq="24" ref="0" bb="32" group="114" />
             </Parameter>
-            <Parameter id="NUdTeWWq1EyNO_DAgFdo8g" name="Radius (small pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="9E-08" displayUnit="µm">
+            <Parameter id="Sk_T3iv5B0GlFDUWVpRv3w" name="Hydraulic conductivity" icon="Parameter" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="3.88888888888889E-11" displayUnit="ml/min/N">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-              <Info min="0" flag="122" seq="24" ref="0" bb="32" group="99" />
+              <Info min="0" flag="122" seq="24" ref="0" bb="32" group="115" />
             </Parameter>
-            <Parameter id="Cpzatsbe-0qwMymGXqQHlg" name="Flow fraction via large pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.8">
+            <Parameter id="ZXxKxzXWz0yGP2sbJCPdwA" name="Radius (large pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="3.3E-07" displayUnit="µm">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-              <Info min="0" max="1" flag="122" seq="24" ref="0" bb="32" group="114" />
+              <Info min="0" flag="122" seq="24" ref="0" bb="32" group="55" />
             </Parameter>
-            <Parameter id="-5Bh--i4n0-T_wCKpYENoQ" name="Radius (large pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="3.3E-07" displayUnit="µm">
+            <Parameter id="d-LHc5RCo0mV-NTFNR27gw" name="Radius (small pores)" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="9E-08" displayUnit="µm">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-              <Info min="0" flag="122" seq="24" ref="0" bb="32" group="55" />
+              <Info min="0" flag="122" seq="24" ref="0" bb="32" group="99" />
             </Parameter>
-            <Parameter id="4Yn7HGFOQUSyxQJO1xYRmQ" name="Vf (lipid)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.016">
+            <Parameter id="xYZoYlYtgkugmVo4BZiANA" name="Vf (lipid)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.016">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
@@ -13652,45 +13723,45 @@
               <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
               <Info min="0" max="1" flag="122" seq="72" ref="0" bb="32" group="85" />
             </Parameter>
-            <Parameter id="F00JQ7_VskSO5-6wDwG9Dw" name="Vf (neutral lipid)-PT" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0201">
+            <Parameter id="VIv1jIcwHkqNBzwiZXzc3Q" name="Vf (neutral lipid)-PT" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0201">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
               <Info min="0" max="1" flag="122" seq="72" ref="0" bb="32" group="86" />
             </Parameter>
-            <Parameter id="tXgDg8dLb0eqGsF4Zes20g" name="Vf (phospholipid)-PT" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0198">
+            <Parameter id="1SWs1TT60Eyv2SwMcJ-iqg" name="Fraction vascular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.33">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
-              <Info min="0" max="1" flag="122" seq="73" ref="0" bb="32" group="86" />
+              <ValueOrigin id="40" source="Publication" description="Edginton, A.N., Schmitt, W. &amp; Willmann, S. Clin Pharmacokinet (2006) 45: 1013. https://doi.org/10.2165/00003088-200645100-00005" />
+              <Info min="0" max="1" flag="62" seq="73" ref="0" bb="32" group="64" />
             </Parameter>
-            <Parameter id="XIRi02lg40GPvqhvESl0Bg" name="Vf (protein)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.194">
+            <Parameter id="nengNceuG0y4IlTLKwha1g" name="Vf (phospholipid)-PT" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0198">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
-              <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
-              <Info min="0" max="1" flag="122" seq="73" ref="0" bb="32" group="85" />
+              <Info min="0" max="1" flag="122" seq="73" ref="0" bb="32" group="86" />
             </Parameter>
-            <Parameter id="tK7_YzRho02nTf7zjg9sKw" name="Fraction vascular" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.33">
+            <Parameter id="7SFe6mt400GlJ5Iv4Riv0w" name="Vf (protein)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.194">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
-              <ValueOrigin id="40" source="Publication" description="Edginton, A.N., Schmitt, W. &amp; Willmann, S. Clin Pharmacokinet (2006) 45: 1013. https://doi.org/10.2165/00003088-200645100-00005" />
-              <Info min="0" max="1" flag="62" seq="73" ref="0" bb="32" group="64" />
+              <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
+              <Info min="0" max="1" flag="122" seq="73" ref="0" bb="32" group="85" />
             </Parameter>
-            <Parameter id="GbVRhVPxPky6T7OGxHc-Dw" name="Vf (water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.778">
+            <Parameter id="dx0vblPc9EWytavXxfoALw" name="Albumin ratio (tissue/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.097">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
-              <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
-              <Info min="0" max="1" flag="122" seq="74" ref="0" bb="32" group="85" />
+              <ValueOrigin id="22" source="Publication" description="Rodgers T, Rowland M. Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J Pharm Sci. 2006 Jun;95(6):1238-57 https://doi.org/10.1002/jps.20502" />
+              <Info min="0" max="1" flag="122" seq="74" ref="0" bb="32" group="111" />
             </Parameter>
-            <Parameter id="55UT-JzsNkq-gd4GUIlK0Q" name="Albumin ratio (tissue/plasma)-PT" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+            <Parameter id="2sPxD4p-LEKsZMe0s5RBsA" name="Albumin ratio (tissue/plasma)-PT" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
@@ -13698,30 +13769,30 @@
               <ValueOrigin id="24" source="Publication" description="POULIN P, THEIL F. Prediction of Pharmacokinetics Prior to In Vivo Studies. 1. Mechanism-Based Prediction of Volume of Distribution. JOURNAL OF PHARMACEUTICAL SCIENCES, VOL. 91, NO. 1, JANUARY 2002" />
               <Info min="0" max="1" flag="122" seq="74" ref="0" bb="32" group="112" />
             </Parameter>
-            <Parameter id="n4jCQHCyNUGLHvC0HU0s_w" name="Vf (water)-PT" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.788">
+            <Parameter id="d7XTl-tT2kqOvzZVSs2Ryg" name="Lipoprotein ratio (tissue/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.207">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
-              <Info min="0" max="1" flag="122" seq="74" ref="0" bb="32" group="86" />
+              <ValueOrigin id="22" source="Publication" description="Rodgers T, Rowland M. Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J Pharm Sci. 2006 Jun;95(6):1238-57 https://doi.org/10.1002/jps.20502" />
+              <Info min="0" max="1" flag="122" seq="74" ref="0" bb="32" group="113" />
             </Parameter>
-            <Parameter id="y5jhP--9MkGR5LYGZikeUQ" name="Albumin ratio (tissue/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.097">
+            <Parameter id="aVSDMHmcg0iv91efw9Jtcg" name="Vf (water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.778">
               <Tags>
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
-              <ValueOrigin id="22" source="Publication" description="Rodgers T, Rowland M. Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J Pharm Sci. 2006 Jun;95(6):1238-57 https://doi.org/10.1002/jps.20502" />
-              <Info min="0" max="1" flag="122" seq="74" ref="0" bb="32" group="111" />
+              <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
+              <Info min="0" max="1" flag="122" seq="74" ref="0" bb="32" group="85" />
             </Parameter>
-            <Parameter id="oWQdSkDO8EKwXu8ZRnDp3A" name="Lipoprotein ratio (tissue/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.207">
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+            <Parameter id="kdTcvOogrUygIjsZqH4eVA" name="Fraction interstitial" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.15">
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                 <Tag value="TissueOrgan" />
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+                <Parameter id="apAsxJQHMk-476grie9XFQ" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.344224880569082" displayUnit="l">
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+                <Parameter id="72-GwLIJR0aNxjUo8sDW0g" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.24341181216" displayUnit="l">
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+                <Parameter id="3lxjLDBZXk-Zb0qjYxorjg" name="GeometricDeviation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.5">
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@@ -13820,17 +13891,18 @@
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
+              <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
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+            <DistributedParameter id="o8u0-BzAJ0SDe-dZTPg0FQ" name="Specific blood flow rate" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" formula="IY6JtcbS3UKE27X9r4NEUw" mode="Logical" isDefault="1" displayUnit="ml/min/100g organ">
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+                <Parameter id="TdtMHocnq0m0_1Q9QkHpBA" name="Deviation" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.04005625" displayUnit="ml/min/100g organ">
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@@ -13838,113 +13910,114 @@
                 <Tag value="Portal Vein Supplying Organ" />
                 <Tag value="TissueOrgan" />
               </Tags>
+              <ValueOrigin id="40" source="Publication" description="Edginton, A.N., Schmitt, W. &amp; Willmann, S. Clin Pharmacokinet (2006) 45: 1013. https://doi.org/10.2165/00003088-200645100-00005" />
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             </DistributedParameter>
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                 <Tag value="Portal Vein Supplying Organ" />
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+                <Parameter id="Ose3OPsqAk2aPsZXrbVtHw" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
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+                <Parameter id="diCOpTVgAECbto_ZHHyzbg" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" isDefault="1" displayUnit="l">
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                 </Parameter>
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+                    <Parameter id="9GpGo1vqPkKxM9iSEAdvBA" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" isDefault="1">
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+                    <Parameter id="_3jqW7BpYEq5RMwm_CB7Fw" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" isDefault="1">
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                 <Tag value="Portal Vein Supplying Organ" />
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+                <Parameter id="T4hKVA8sg0OjbqQxOHm9Yg" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" isDefault="1" displayUnit="l">
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+                <Parameter id="wIiWD_12REyjGs7PkaNw2w" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" isDefault="1" displayUnit="l">
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+                <Parameter id="N6g9ED4Ty0iiU0XlkUZmdA" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_pH_INT" isDefault="1">
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+                    <Parameter id="OiWpGbzKy065bBi8ZctJ9g" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
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+                    <Parameter id="T6nPpjYJp0G9RyV8MO8iRw" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_spl" isDefault="1">
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+                    <Parameter id="VC6Qpi4cx0GoFYIRZkoX8A" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
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                 <Tag value="Portal Vein Supplying Organ" />
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+                <Parameter id="M0-brBbfm0S7ZjXKphWMiQ" name="Volume of protein container" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" isDefault="1" displayUnit="l">
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+                <Parameter id="pYCCCrOI0U2wgYY7qJXw8g" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" isDefault="1" displayUnit="l">
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-                <Parameter id="yqk-dj1wYEuXA5NtB68_Vg" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7">
+                <Parameter id="csoQi3ClL0STlJ1FZP6iiw" name="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7">
                   <Tags>
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@@ -13952,15 +14025,15 @@
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                 </Parameter>
-                <Container id="_23n83LFMU6gAhSNnw0Xjw" name="MoleculeProperties" mode="Logical" containerType="Molecule">
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+                    <Parameter id="NImsgQ3Ts02K7ncP00_8tg" name="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" isDefault="1">
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+                    <Parameter id="ynmZLae0SECR4L79yDVAVg" name="Partition coefficient (water/container)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_spl" isDefault="1">
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+                    <Parameter id="KCJJGiEgZEGxS5nqvrkcrw" name="t1/2" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_ProteinHalfLife_FromGlobal_Liver" isDefault="1" displayUnit="min">
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@@ -13969,184 +14042,145 @@
             </Container>
           </Children>
         </Container>
-        <Container id="GvrHWhGlT0WQHVtEwacT4A" name="Saliva" mode="Logical" containerType="Organ">
+        <Container id="ltubkaH9Hkirz0N5VgiYVw" name="Saliva" mode="Logical" containerType="Organ">
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+            <Parameter id="TvyQw4hvHkKOuMlDuAYIlA" name="Weight (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.PARAM_Tissue_Weight" isDefault="1" displayUnit="kg">
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+            <Parameter id="NJoiPW65gEGGl3ooeC6-Cw" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="Individual_PKSim.VOLUME_Saliva_Organ" isDefault="1" displayUnit="l">
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+            <Parameter id="yZeBabBHEUyeXYNxGvG4XQ" name="Density (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
+              <Info min="0" flag="38" seq="1" ref="0" bb="32" group="21" />
+            </Parameter>
+            <Parameter id="8aldQreU_kyroqbqit-3XA" name="Saliva flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.001" displayUnit="l/min">
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+                <Parameter id="yE7brQPHXk6-Ctd_HEbqTA" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_slv_slv" isDefault="1" displayUnit="l">
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+                <Parameter id="2izDMG2wYE-wD96xRfNriw" name="pH (saliva)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.4">
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+                <Parameter id="5oisS8fpokWkoRYaZhIx5A" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="CompartmentsVolume_4Comp.VOLUME_slv_slv" isDefault="1" displayUnit="l">
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-          <Parameter id="Rj3r5gbxukOoQIezVqrRYA" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" isDefault="1" displayUnit="cm²">
+          <Container id="vY3-gL8RJ0-wS30a9pinAw" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Parameter id="6DNPhpD9qki0q_iq6qNWnA" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls_Blood_Organ" isDefault="1" displayUnit="cm²">
             <Tags>
               <Tag value="Neighborhood: Plasma / BloodCells" />
             </Tags>
-            <Info min="0" flag="122" seq="3" ref="0" bb="32" group="104" />
+            <Info min="0" flag="122" seq="2" ref="0" bb="32" group="104" />
           </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="NgVnolBMB0SljrpnXs60DQ" name="Bone_bc_VenousBlood_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="DbQyEVwBkkGasudwqonNkQ" secondNeighbor="H3YIKhsT9kW_XjjpUkxqNg">
+      <NeighborhoodBuilder id="-kIAluRFRUiAAH3e6iNmMQ" name="Bone_bc_VenousBlood_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="-7WVSSWNzkKawuJR1P1WQw" secondNeighbor="bHtbzf2QTkS9BPP8ck7mNg">
         <Tags>
           <Tag value="Neighborhood: BloodCells / BloodCells" />
         </Tags>
         <Children>
-          <Container id="LhlJB0MIrUqsOr6glwOJ5g" name="MoleculeProperties" mode="Logical" containerType="Other" />
-        </Children>
-      </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="4a7KmitrAUqdFHFR627h_Q" name="Bone_pls_Bone_int" mode="Logical" containerType="Neighborhood" firstNeighbor="UAIpUXIFkky5Ko3nFNVA2w" secondNeighbor="s-JCTEHhZEWJ6sWxl9SyjA">
-        <Tags>
-          <Tag value="Neighborhood: Plasma / Interstitial" />
-        </Tags>
-        <Children>
-          <Container id="7EFneUoJMkKaFmWlsR4l4g" name="MoleculeProperties" mode="Logical" containerType="Other">
-            <Children>
-              <Parameter id="_ux6F3MKjk-432lf9VyxkQ" name="P (plasma&lt;-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
-                <ValueOrigin id="49" method="Assumption" description="TODO: Default: very fast exchange" />
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="77" />
-              </Parameter>
-              <Parameter id="PZmX0dzXl0aWQKxkDolMag" name="Partition coefficient (interstitial/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" isDefault="1">
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="70" />
-              </Parameter>
-            </Children>
-          </Container>
-          <Parameter id="clD9GuPa3kqT2w92HQLLAw" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" isDefault="1" displayUnit="cm²">
-            <Tags>
-              <Tag value="Neighborhood: Plasma / Interstitial" />
-            </Tags>
-            <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-            <Info min="0" flag="122" seq="1" ref="0" bb="32" group="106" />
-          </Parameter>
+          <Container id="cGg95_bxzk2nkYZa_N91UA" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="p7zE7MfeGkGeotuffg6j6Q" name="Bone_int_Bone_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="s-JCTEHhZEWJ6sWxl9SyjA" secondNeighbor="OZwyijncuUCfTAtyFAv4pQ">
+      <NeighborhoodBuilder id="eNYFlwxeOEuzUnvrJ86SZA" name="Bone_int_Bone_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="teesWRePUku7eNKHrwsimg" secondNeighbor="oqcD8Ok_Rkqcn4uurotLfg">
         <Tags>
           <Tag value="Neighborhood: Interstitial / Intracellular" />
         </Tags>
         <Children>
-          <Container id="uiKHJUEtRUKQVU2XWyDrvg" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="7AZQBYFjk0qgvzUo9PrMRQ" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="VsBKOUtcP0CUxnDOwUkurw" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+              <Parameter id="yEdjIfKDQkyim5xAVphQlg" name="P (interstitial-&gt;intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" isDefault="1" displayUnit="cm/min">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="78" />
               </Parameter>
-              <Parameter id="GH3zNW6Bf0yCoyAPqhlKEA" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+              <Parameter id="VIqiFeOgsE-MAFRSOhzvgw" name="P (intracellular-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" isDefault="1" displayUnit="cm/min">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="76" />
               </Parameter>
-              <Parameter id="mvqCxTXLC0eR8VXjIR8jdg" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="69" />
+              <Parameter id="T4d2J1cy-06YWpB11iGkfQ" name="P*SA interstitial -&gt; intracellular" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" isDefault="1" displayUnit="l/min">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="57kRtjyfwkmvnlFmptXPJQ" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
+              <Parameter id="FYD7JBpeLUSzeP7mY2VxXQ" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="l2lwLWyFJkWrfvn22kKYSQ" name="P*SA interstitial -&gt; intracellular" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" isDefault="1" displayUnit="l/min">
+              <Parameter id="ud84_oXPJU2SIywdWXkLwg" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="zxClXY7rZkeN0qJL6XAxjg" name="P (intracellular-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" isDefault="1" displayUnit="cm/min">
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="76" />
+              <Parameter id="fRt22q2f_0WQY7l2IA_zOw" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="Xzhc2lpdUk-CRDt5J2wySw" name="P (interstitial-&gt;intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" isDefault="1" displayUnit="cm/min">
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="78" />
+              <Parameter id="TYPR-DWakkyQQkKSd_yC7Q" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="69" />
               </Parameter>
-              <Parameter id="hErQSOW5L0KoS0b5RZrzzg" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+              <Parameter id="km6FVhtk-UycUivq6Hpscw" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
               </Parameter>
             </Children>
           </Container>
-          <Parameter id="HuSh77hp-0aM__npTiVMRw" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_bon" isDefault="1" displayUnit="cm²">
+          <Parameter id="-xOP3zTMbkyXGt6V04WL3A" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_bon" isDefault="1" displayUnit="cm²">
             <Tags>
               <Tag value="Neighborhood: Interstitial / Intracellular" />
             </Tags>
@@ -14154,102 +14188,95 @@
           </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="2YxkTQO08EiGFNUZv7Snxw" name="Bone_pls_VenousBlood_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="UAIpUXIFkky5Ko3nFNVA2w" secondNeighbor="dt7fUpCxbUGcr9pNef8UCA">
+      <NeighborhoodBuilder id="NA8srS2lf0ekMgoGtIZK6Q" name="Bone_pls_Bone_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="FMXrCszwd0aA9SPmflV1pA" secondNeighbor="-7WVSSWNzkKawuJR1P1WQw">
         <Tags>
-          <Tag value="Neighborhood: Plasma / Plasma" />
+          <Tag value="Neighborhood: Plasma / BloodCells" />
         </Tags>
         <Children>
-          <Container id="KoxBX7-D1UaDOvBfhFDCgg" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="O7BHeTvyykaGeB5j1RdIjQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Parameter id="UqnOuL7BOk2UE-dAMKAJTw" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" isDefault="1" displayUnit="cm²">
+            <Tags>
+              <Tag value="Neighborhood: Plasma / BloodCells" />
+            </Tags>
+            <Info min="0" flag="122" seq="3" ref="0" bb="32" group="104" />
+          </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="6o0KcL9I_0upHHvhVtmBcA" name="Brain_pls_Brain_int" mode="Logical" containerType="Neighborhood" firstNeighbor="Tee3u8NeokOhMw6f8dSh0A" secondNeighbor="E3frYmlADUCgUSLuYPaIig">
+      <NeighborhoodBuilder id="DjX5YV5AhEaBy8GCXgAlBw" name="Bone_pls_Bone_int" mode="Logical" containerType="Neighborhood" firstNeighbor="FMXrCszwd0aA9SPmflV1pA" secondNeighbor="teesWRePUku7eNKHrwsimg">
         <Tags>
           <Tag value="Neighborhood: Plasma / Interstitial" />
         </Tags>
         <Children>
-          <Container id="dfZb-Apqr0SdbsIPD1oOlg" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="oDWEMEwES0GXOQZA1w4AFA" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="rp2ibF_KFUCPLogo5HdxaQ" name="Partition coefficient (interstitial/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" isDefault="1">
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="70" />
-              </Parameter>
-              <Parameter id="ZJWBri_6L0i3K3-u2nVdsw" name="P (plasma&lt;-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_PKSim.PARAM_P_endothelial_Brain" isDefault="1" displayUnit="cm/min">
+              <Parameter id="bLxX9L_p-UOezs8O21NK5w" name="P (plasma&lt;-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
+                <ValueOrigin id="49" source="Other" method="Assumption" description="Assumption: very fast exchange" />
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="77" />
               </Parameter>
+              <Parameter id="zXjh1Fl06U-q_Xx37-Ukwg" name="Partition coefficient (interstitial/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" isDefault="1">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="70" />
+              </Parameter>
             </Children>
           </Container>
-          <Parameter id="S9-8decuIEWXDTZhUNJgZA" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" isDefault="1" displayUnit="cm²">
+          <Parameter id="6xBiuUKbK0O3rphErGtqXA" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" isDefault="1" displayUnit="cm²">
             <Tags>
               <Tag value="Neighborhood: Plasma / Interstitial" />
             </Tags>
             <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-            <Info min="0" flag="122" seq="2" ref="0" bb="32" group="106" />
+            <Info min="0" flag="122" seq="1" ref="0" bb="32" group="106" />
           </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="XviAWfH1Z0uA_BjtxPgWHQ" name="Brain_pls_Brain_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="Tee3u8NeokOhMw6f8dSh0A" secondNeighbor="FcxxDdjBhUKABUVCEaoBQw">
+      <NeighborhoodBuilder id="2FqGM9t_90e9Qo0LZNMEsA" name="Bone_pls_VenousBlood_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="FMXrCszwd0aA9SPmflV1pA" secondNeighbor="Ans5EKfuF0W1dnzkXjqTlg">
         <Tags>
-          <Tag value="Neighborhood: Plasma / BloodCells" />
+          <Tag value="Neighborhood: Plasma / Plasma" />
         </Tags>
         <Children>
-          <Container id="yHHvCc-cVUSDN4KQFVYP9A" name="MoleculeProperties" mode="Logical" containerType="Other" />
-          <Parameter id="rAUAvs3nIEqCDT8pzW_p3A" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" isDefault="1" displayUnit="cm²">
-            <Tags>
-              <Tag value="Neighborhood: Plasma / BloodCells" />
-            </Tags>
-            <Info min="0" flag="122" seq="4" ref="0" bb="32" group="104" />
-          </Parameter>
+          <Container id="23NZ1pscZ0CoWOxKIf8prg" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="gyZxPCpHake6hvAPoSCznA" name="Brain_bc_VenousBlood_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="FcxxDdjBhUKABUVCEaoBQw" secondNeighbor="H3YIKhsT9kW_XjjpUkxqNg">
+      <NeighborhoodBuilder id="-DMlRt1HvkiiRHuUdYIorA" name="Brain_bc_VenousBlood_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="_kM6rV4F-UGU7WOAUGLsGw" secondNeighbor="bHtbzf2QTkS9BPP8ck7mNg">
         <Tags>
           <Tag value="Neighborhood: BloodCells / BloodCells" />
         </Tags>
         <Children>
-          <Container id="bqoIhNK7mEC7r-mfiBGkkQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
-        </Children>
-      </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="XNVYU68OKUO59Y4U-hq22w" name="Brain_pls_VenousBlood_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="Tee3u8NeokOhMw6f8dSh0A" secondNeighbor="dt7fUpCxbUGcr9pNef8UCA">
-        <Tags>
-          <Tag value="Neighborhood: Plasma / Plasma" />
-        </Tags>
-        <Children>
-          <Container id="oYQ8W8gVOEicPIyzWrlK7g" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="Bjq9YxnaZ0-so5WoiFgDFg" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="TxNGBrsmDEy0r8xpxkv0gg" name="Brain_int_Brain_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="E3frYmlADUCgUSLuYPaIig" secondNeighbor="PRoBTwV1tkOTdFsrXpIbvQ">
+      <NeighborhoodBuilder id="0D-QtJprLkiyg6QoeffWXQ" name="Brain_int_Brain_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="ADDQZ02oqE2UpCNzxzZbDA" secondNeighbor="W9Tmg9hHNkOrO3OgeRFoHg">
         <Tags>
           <Tag value="Neighborhood: Interstitial / Intracellular" />
         </Tags>
         <Children>
-          <Container id="q5O7o9RDRUSQBeo1qoHKwQ" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="o9616Z2w20qZ0tY1E7XvKg" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="ZFw_fJZfhkW1xr7q0rnyPQ" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+              <Parameter id="VkrxsdMjzkKv8AlhhS_abA" name="P (interstitial-&gt;intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" isDefault="1" displayUnit="cm/min">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="78" />
               </Parameter>
-              <Parameter id="KMItNxhYEUmj2k7KiRRNMA" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="69" />
+              <Parameter id="b0gX1aba3UaOmorHJbOG2g" name="P (intracellular-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" isDefault="1" displayUnit="cm/min">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="76" />
               </Parameter>
-              <Parameter id="UasyOJHPqkm3YzJlWljqeQ" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
+              <Parameter id="ORAIQkhjXUWYSyclWHl9BA" name="P*SA interstitial -&gt; intracellular" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" isDefault="1" displayUnit="l/min">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="23iWH9I3uU6lxrf2NGvsqA" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
+              <Parameter id="amZFJv8Ey0KgOaVzrDADnQ" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="8EwSiAZc00qrrSzs5dibCg" name="P*SA interstitial -&gt; intracellular" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" isDefault="1" displayUnit="l/min">
+              <Parameter id="Fn5JnDq-bkKkmDDijwVvzg" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="tbKU-j5XhkOkkDiJgkL6dg" name="P (intracellular-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" isDefault="1" displayUnit="cm/min">
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="76" />
+              <Parameter id="_LZ7ZR_6SEyot1waXctY9A" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="rfdKJD26jkKwHAuWnHMq4g" name="P (interstitial-&gt;intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" isDefault="1" displayUnit="cm/min">
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="78" />
+              <Parameter id="LfOP7JAQX0G5l4Cb1pIvEg" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="69" />
               </Parameter>
-              <Parameter id="qz8FMOvn1U6QxtcZNhQE5g" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
+              <Parameter id="O4LglsSIxEikCkZnNJzgpw" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
               </Parameter>
             </Children>
           </Container>
-          <Parameter id="oHIP9X-0jUqdhKvVR_Ct8Q" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_brn" isDefault="1" displayUnit="cm²">
+          <Parameter id="RtQL2ZlAQUK_C20hb10nYA" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_brn" isDefault="1" displayUnit="cm²">
             <Tags>
               <Tag value="Neighborhood: Interstitial / Intracellular" />
             </Tags>
@@ -14257,48 +14284,94 @@
           </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="PjXwnL25k0-OUOt8cKL8zg" name="Fat_pls_VenousBlood_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="kDtt8apkd0ilEw0l7X3Efw" secondNeighbor="dt7fUpCxbUGcr9pNef8UCA">
+      <NeighborhoodBuilder id="d2lCAPSyn021tSnoe-Lbxg" name="Brain_pls_Brain_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="b_tNtdP4bkKB5t081UctTA" secondNeighbor="_kM6rV4F-UGU7WOAUGLsGw">
+        <Tags>
+          <Tag value="Neighborhood: Plasma / BloodCells" />
+        </Tags>
+        <Children>
+          <Container id="mfuoJ4yEFEWtIUIhQWakYQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Parameter id="MV61aTMGm0yF9hRNVG2aJg" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" isDefault="1" displayUnit="cm²">
+            <Tags>
+              <Tag value="Neighborhood: Plasma / BloodCells" />
+            </Tags>
+            <Info min="0" flag="122" seq="4" ref="0" bb="32" group="104" />
+          </Parameter>
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="vc5ouZ5_JU2SIlhxv_tsZg" name="Brain_pls_Brain_int" mode="Logical" containerType="Neighborhood" firstNeighbor="b_tNtdP4bkKB5t081UctTA" secondNeighbor="ADDQZ02oqE2UpCNzxzZbDA">
+        <Tags>
+          <Tag value="Neighborhood: Plasma / Interstitial" />
+        </Tags>
+        <Children>
+          <Container id="p-N_mAMlcUmpAkcVI5DoqQ" name="MoleculeProperties" mode="Logical" containerType="Other">
+            <Children>
+              <Parameter id="vwFijrF1pE-INAmz249Bew" name="P (plasma&lt;-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionPlasma_PKSim.PARAM_P_endothelial_Brain" isDefault="1" displayUnit="cm/min">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="77" />
+              </Parameter>
+              <Parameter id="QTzPMnLTa02Gh6EFGNHDGQ" name="Partition coefficient (interstitial/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" isDefault="1">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="70" />
+              </Parameter>
+            </Children>
+          </Container>
+          <Parameter id="IZw_M49Vd0CkOPdh1rTjuA" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" isDefault="1" displayUnit="cm²">
+            <Tags>
+              <Tag value="Neighborhood: Plasma / Interstitial" />
+            </Tags>
+            <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+            <Info min="0" flag="122" seq="2" ref="0" bb="32" group="106" />
+          </Parameter>
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="GU1i7XcCnUC8Ten-ysHAUQ" name="Brain_pls_VenousBlood_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="b_tNtdP4bkKB5t081UctTA" secondNeighbor="Ans5EKfuF0W1dnzkXjqTlg">
         <Tags>
           <Tag value="Neighborhood: Plasma / Plasma" />
         </Tags>
         <Children>
-          <Container id="rNMmhIaj_0ScTpjkoNHG5A" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="RhixeG_yc0-U14qcEF2n9A" name="MoleculeProperties" mode="Logical" containerType="Other" />
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="_rReMuM5pkC6z6dHBFdFeg" name="Fat_bc_VenousBlood_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="aPjmRFIx1UCuIZcC05FS-Q" secondNeighbor="bHtbzf2QTkS9BPP8ck7mNg">
+        <Tags>
+          <Tag value="Neighborhood: BloodCells / BloodCells" />
+        </Tags>
+        <Children>
+          <Container id="KvNKmaUNP0-EVfpN0MG29g" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="YAzgW87EM0-JnOIzM2CRTQ" name="Fat_int_Fat_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="yYLFKBbJQke22TvdmtJWlw" secondNeighbor="P34sCyhx_EC3cvyRjF0o2A">
+      <NeighborhoodBuilder id="BrHCvHi1ukuzM3GaM5hnOA" name="Fat_int_Fat_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="SLhuNup-AUWvsW6IFgBIdg" secondNeighbor="5xqprJ-ANESP7f87XxNBsA">
         <Tags>
           <Tag value="Neighborhood: Interstitial / Intracellular" />
         </Tags>
         <Children>
-          <Container id="TpN0cvZBOkmv_Y7VQwj63Q" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="HgPO9OXJukKqfKNvF4dZBA" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="KupQ9UcsTEONhufGlFZQpA" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="69" />
+              <Parameter id="FYYQdTFMVEiWpF3NDDpvLg" name="P (interstitial-&gt;intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" isDefault="1" displayUnit="cm/min">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="78" />
               </Parameter>
-              <Parameter id="u67mvxd0rEuTN68mm_Tubw" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+              <Parameter id="pSuOPRJHFUiI7uWq94eZvw" name="P (intracellular-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" isDefault="1" displayUnit="cm/min">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="76" />
               </Parameter>
-              <Parameter id="abOjBhHOkkOOQLMmMlshgw" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
+              <Parameter id="CFmzpHPplUGhrr-DM4uWIQ" name="P*SA interstitial -&gt; intracellular" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" isDefault="1" displayUnit="l/min">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="N5iWIlQd6Uiq7iVUzm-EBg" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
+              <Parameter id="rKtCbIf-IEWlBDGcb1XjNw" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="EppyvysNqkC2YkZzy24VEQ" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
+              <Parameter id="k65Me-i3_021VCdoQvfsLQ" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="vOECXRk5jE2t_G5YSNTAKQ" name="P*SA interstitial -&gt; intracellular" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" isDefault="1" displayUnit="l/min">
+              <Parameter id="2sIK__fPPEufuXGKWPaxHw" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="rK6K4Jh1xEusH_1OGsD31Q" name="P (intracellular-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" isDefault="1" displayUnit="cm/min">
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="76" />
+              <Parameter id="FgIQmezniE24CLbugraEwA" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="69" />
               </Parameter>
-              <Parameter id="WNR5Va-E30SFkegDA_8eKw" name="P (interstitial-&gt;intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" isDefault="1" displayUnit="cm/min">
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="78" />
+              <Parameter id="FVh5QvamU0CrRa6mDG3Kag" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
               </Parameter>
             </Children>
           </Container>
-          <Parameter id="sGTOldG78EWoeKqfWU8T_g" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_fat" isDefault="1" displayUnit="cm²">
+          <Parameter id="35PvqU96ZkScGPQug12RPA" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_fat" isDefault="1" displayUnit="cm²">
             <Tags>
               <Tag value="Neighborhood: Interstitial / Intracellular" />
             </Tags>
@@ -14306,23 +14379,37 @@
           </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="KeErZm4uRUW9fKyaGTulqQ" name="Fat_pls_Fat_int" mode="Logical" containerType="Neighborhood" firstNeighbor="kDtt8apkd0ilEw0l7X3Efw" secondNeighbor="yYLFKBbJQke22TvdmtJWlw">
+      <NeighborhoodBuilder id="EF-hrHflnU-jHEyUMMOmsg" name="Fat_pls_Fat_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="eEFhJbl1wESGjgKaGVF2Tw" secondNeighbor="aPjmRFIx1UCuIZcC05FS-Q">
+        <Tags>
+          <Tag value="Neighborhood: Plasma / BloodCells" />
+        </Tags>
+        <Children>
+          <Container id="U3OLTXPhIkWciuPrEMGR8g" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Parameter id="YyYZu4pvtUK8qPl9SGkoMA" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" isDefault="1" displayUnit="cm²">
+            <Tags>
+              <Tag value="Neighborhood: Plasma / BloodCells" />
+            </Tags>
+            <Info min="0" flag="122" seq="5" ref="0" bb="32" group="104" />
+          </Parameter>
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="1ytXqR3GPE6V44LX0B68yQ" name="Fat_pls_Fat_int" mode="Logical" containerType="Neighborhood" firstNeighbor="eEFhJbl1wESGjgKaGVF2Tw" secondNeighbor="SLhuNup-AUWvsW6IFgBIdg">
         <Tags>
           <Tag value="Neighborhood: Plasma / Interstitial" />
         </Tags>
         <Children>
-          <Container id="4PdKZcM8bEWsJGs2yPsIaw" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="Tl90NTgcIUm9h5gtNBdkvA" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="pMNBByE-lU-yppgK_0mTyA" name="Partition coefficient (interstitial/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" isDefault="1">
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="70" />
-              </Parameter>
-              <Parameter id="RpDVecdXs0mxyEJX6kL6IQ" name="P (plasma&lt;-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
-                <ValueOrigin id="49" method="Assumption" description="TODO: Default: very fast exchange" />
+              <Parameter id="zDtQJzIvMUGg4JIcvUeRPA" name="P (plasma&lt;-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
+                <ValueOrigin id="49" source="Other" method="Assumption" description="Assumption: very fast exchange" />
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="77" />
               </Parameter>
+              <Parameter id="YozKDTzEjUycSO9e17H0nQ" name="Partition coefficient (interstitial/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" isDefault="1">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="70" />
+              </Parameter>
             </Children>
           </Container>
-          <Parameter id="NjhpIKoqMk-lsAybyXHlEA" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" isDefault="1" displayUnit="cm²">
+          <Parameter id="HIR6hvoUikWMHZpejyVzvw" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" isDefault="1" displayUnit="cm²">
             <Tags>
               <Tag value="Neighborhood: Plasma / Interstitial" />
             </Tags>
@@ -14331,53 +14418,94 @@
           </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="4QNVth-dYE6AQKaiSw8uAQ" name="Fat_pls_Fat_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="kDtt8apkd0ilEw0l7X3Efw" secondNeighbor="8gJ8K-5eO0uYBeg7VL1woA">
+      <NeighborhoodBuilder id="g-VtbGi1yUqIkJlIvHmgdw" name="Fat_pls_VenousBlood_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="eEFhJbl1wESGjgKaGVF2Tw" secondNeighbor="Ans5EKfuF0W1dnzkXjqTlg">
         <Tags>
-          <Tag value="Neighborhood: Plasma / BloodCells" />
+          <Tag value="Neighborhood: Plasma / Plasma" />
         </Tags>
         <Children>
-          <Container id="Mte1m2GHoE-AzAfPTFXVcw" name="MoleculeProperties" mode="Logical" containerType="Other" />
-          <Parameter id="1_jYp7_egk6ZNHz7SsP4Sw" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" isDefault="1" displayUnit="cm²">
-            <Tags>
-              <Tag value="Neighborhood: Plasma / BloodCells" />
-            </Tags>
-            <Info min="0" flag="122" seq="5" ref="0" bb="32" group="104" />
-          </Parameter>
+          <Container id="XqoAGa2qvkqd4O-XfpEVpg" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="iVv2ilZEYUOfDrLH-fvcAA" name="Fat_bc_VenousBlood_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="8gJ8K-5eO0uYBeg7VL1woA" secondNeighbor="H3YIKhsT9kW_XjjpUkxqNg">
+      <NeighborhoodBuilder id="mG27965pUE-YLgCYpFQy3Q" name="Gonads_bc_VenousBlood_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="v8soZXA6DU6TH8algfr0uQ" secondNeighbor="bHtbzf2QTkS9BPP8ck7mNg">
         <Tags>
           <Tag value="Neighborhood: BloodCells / BloodCells" />
         </Tags>
         <Children>
-          <Container id="HzCKkduuF0iyb0YNPNWIxA" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="WP4y1L8AwUCFM4ofJKWeyg" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="pc0AE-wqLEGCDmI044UP1Q" name="Gonads_pls_VenousBlood_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="dQYkOM8WRUWsb3Hw5kGAzQ" secondNeighbor="dt7fUpCxbUGcr9pNef8UCA">
+      <NeighborhoodBuilder id="B9eJPlN46E-lZGGSXa8I3Q" name="Gonads_int_Gonads_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="JS3wrCRC6E-z3utpoHI5Gg" secondNeighbor="rkoI-pNzb0mlJoIUsPyNPw">
         <Tags>
-          <Tag value="Neighborhood: Plasma / Plasma" />
+          <Tag value="Neighborhood: Interstitial / Intracellular" />
         </Tags>
         <Children>
-          <Container id="a9JcKZQICkSAXwZ2ffrTyg" name="MoleculeProperties" mode="Logical" containerType="Other" />
-        </Children>
+          <Container id="phx6lbWWikiySKaKNQxBKA" name="MoleculeProperties" mode="Logical" containerType="Other">
+            <Children>
+              <Parameter id="MLgssBpSbkGyCeJYqClkOA" name="P (interstitial-&gt;intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" isDefault="1" displayUnit="cm/min">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="78" />
+              </Parameter>
+              <Parameter id="DUos8SwhMUiDPfsw4Lxabw" name="P (intracellular-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" isDefault="1" displayUnit="cm/min">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="76" />
+              </Parameter>
+              <Parameter id="v97vZlWg3UKluigyD2T5ww" name="P*SA interstitial -&gt; intracellular" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" isDefault="1" displayUnit="l/min">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="4e-xHO7NWk-GbbJ3uZuZ1g" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="xfCiCPaXj0WjfkBYpD7rqg" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="M7EpBAyOpUmLnJ0A4PLY2w" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="y1kKINnD0EqcdoCLyNtBmg" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="69" />
+              </Parameter>
+              <Parameter id="OdeYYRplpUWO7F45A7CO_A" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+              </Parameter>
+            </Children>
+          </Container>
+          <Parameter id="Td1_V5-2bEKpcHQ1nhdwqw" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_tes" isDefault="1" displayUnit="cm²">
+            <Tags>
+              <Tag value="Neighborhood: Interstitial / Intracellular" />
+            </Tags>
+            <Info min="0" flag="122" seq="4" ref="0" bb="32" group="105" />
+          </Parameter>
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="mryJL1EZ00uFcgDT_yUbcg" name="Gonads_pls_Gonads_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="9ICTIHrDeES9J29X9SvpgQ" secondNeighbor="v8soZXA6DU6TH8algfr0uQ">
+        <Tags>
+          <Tag value="Neighborhood: Plasma / BloodCells" />
+        </Tags>
+        <Children>
+          <Container id="4ZZeyDecD0-HGTKO1-HhXQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Parameter id="0N5THCrq3k23q_InjC3E1g" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" isDefault="1" displayUnit="cm²">
+            <Tags>
+              <Tag value="Neighborhood: Plasma / BloodCells" />
+            </Tags>
+            <Info min="0" flag="122" seq="6" ref="0" bb="32" group="104" />
+          </Parameter>
+        </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="_h0i91BC10GArfkFFNyIQg" name="Gonads_pls_Gonads_int" mode="Logical" containerType="Neighborhood" firstNeighbor="dQYkOM8WRUWsb3Hw5kGAzQ" secondNeighbor="kD2zuevSS0mRrrijXqriPQ">
+      <NeighborhoodBuilder id="FL5O6F-gN0GugxOX6sLaoQ" name="Gonads_pls_Gonads_int" mode="Logical" containerType="Neighborhood" firstNeighbor="9ICTIHrDeES9J29X9SvpgQ" secondNeighbor="JS3wrCRC6E-z3utpoHI5Gg">
         <Tags>
           <Tag value="Neighborhood: Plasma / Interstitial" />
         </Tags>
         <Children>
-          <Container id="6K0EUkBSFEWCbC775VkzFA" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="ULUq9wJbX0WBjC6WM-O3hA" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="sZHVkQp0YEmLChJ5ed-jUg" name="P (plasma&lt;-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
-                <ValueOrigin id="49" method="Assumption" description="TODO: Default: very fast exchange" />
+              <Parameter id="FiLgBTreDEaSRbOzwnVnhw" name="P (plasma&lt;-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
+                <ValueOrigin id="49" source="Other" method="Assumption" description="Assumption: very fast exchange" />
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="77" />
               </Parameter>
-              <Parameter id="CfDdokcfUkqER9qSLJfEBw" name="Partition coefficient (interstitial/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" isDefault="1">
+              <Parameter id="6DEWw2L9TEuhmhvhZNVTSg" name="Partition coefficient (interstitial/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" isDefault="1">
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="70" />
               </Parameter>
             </Children>
           </Container>
-          <Parameter id="nMyluviIZUWCNjS35g3_3A" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" isDefault="1" displayUnit="cm²">
+          <Parameter id="rfXOFGRFFk2a9tM66gQdjw" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" isDefault="1" displayUnit="cm²">
             <Tags>
               <Tag value="Neighborhood: Plasma / Interstitial" />
             </Tags>
@@ -14386,94 +14514,94 @@
           </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="Hro5ZqOkEkCjxJmeCC0RJA" name="Gonads_pls_Gonads_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="dQYkOM8WRUWsb3Hw5kGAzQ" secondNeighbor="4ljY8xwxP0K1LdmospwNkg">
+      <NeighborhoodBuilder id="FfwiXesP9UGakprPe8mOEg" name="Gonads_pls_VenousBlood_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="9ICTIHrDeES9J29X9SvpgQ" secondNeighbor="Ans5EKfuF0W1dnzkXjqTlg">
         <Tags>
-          <Tag value="Neighborhood: Plasma / BloodCells" />
+          <Tag value="Neighborhood: Plasma / Plasma" />
         </Tags>
         <Children>
-          <Container id="VuZBR0pduUqH4IGbOrKjLw" name="MoleculeProperties" mode="Logical" containerType="Other" />
-          <Parameter id="OQLE9gMI-kiRZcxT6QVr3A" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" isDefault="1" displayUnit="cm²">
-            <Tags>
-              <Tag value="Neighborhood: Plasma / BloodCells" />
-            </Tags>
-            <Info min="0" flag="122" seq="6" ref="0" bb="32" group="104" />
-          </Parameter>
+          <Container id="oF_c6A2R9kyZJc4sbQj5TA" name="MoleculeProperties" mode="Logical" containerType="Other" />
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="1zky064GSU2Ss58AeDuXdg" name="Heart_bc_VenousBlood_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="lyEOfc6nTEC9WU3_HrdsZw" secondNeighbor="bHtbzf2QTkS9BPP8ck7mNg">
+        <Tags>
+          <Tag value="Neighborhood: BloodCells / BloodCells" />
+        </Tags>
+        <Children>
+          <Container id="zk1ZGUt04EaGvRUeX2rhMw" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="Nw40VxGXx0-pVtPiq_yJOw" name="Gonads_int_Gonads_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="kD2zuevSS0mRrrijXqriPQ" secondNeighbor="0b9PfDC8l0O6nirtF8OPnA">
+      <NeighborhoodBuilder id="7XxAKsEWZUyD_hgjcX5Jtg" name="Heart_int_Heart_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="2tAQOA4XtkG3JwwJMnB6ww" secondNeighbor="xnK8Y03YI0WKbuegsClSDQ">
         <Tags>
           <Tag value="Neighborhood: Interstitial / Intracellular" />
         </Tags>
         <Children>
-          <Container id="Hk9aEPqZwUauqCiTUpDfDg" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="ERQrl44VwkCprcs2XsiT2w" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="oZpmvZO8n06DXPpydyxXOQ" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+              <Parameter id="VHXw3xoFrUOWlUI-hRh6dA" name="P (interstitial-&gt;intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" isDefault="1" displayUnit="cm/min">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="78" />
               </Parameter>
-              <Parameter id="_HrkM_HbgUu9B-TeT4tTyQ" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="69" />
+              <Parameter id="XrdHac4JuEqq6eMfu9sryQ" name="P (intracellular-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" isDefault="1" displayUnit="cm/min">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="76" />
               </Parameter>
-              <Parameter id="lJ26e7xPDU2CV5yPyJo53A" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
+              <Parameter id="SW3A8YkMgEO_iCw-dXXiLw" name="P*SA interstitial -&gt; intracellular" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" isDefault="1" displayUnit="l/min">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="ZJJ1lAwItESmZhMaBALqYg" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
+              <Parameter id="N4HewRScw0uPkEwNIufuMA" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="6xNcUTpe6kG5afefHrl72g" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
+              <Parameter id="agMkoqSfy0-JMsBvX6Smnw" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="WDY0oShwtUC3d80ziFG-KA" name="P*SA interstitial -&gt; intracellular" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" isDefault="1" displayUnit="l/min">
+              <Parameter id="GCxUI1XdCEW7XPa4QkVFgw" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="GNOLNOYmHkiIxZFQ2HODhg" name="P (intracellular-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" isDefault="1" displayUnit="cm/min">
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="76" />
+              <Parameter id="5HKmcHbAJESFvaK2RS43DQ" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="69" />
               </Parameter>
-              <Parameter id="gL98Ql7hkUaYXhbACEuVXQ" name="P (interstitial-&gt;intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" isDefault="1" displayUnit="cm/min">
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="78" />
+              <Parameter id="4u6eD0hhpESUSRItTs8Jjg" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
               </Parameter>
             </Children>
           </Container>
-          <Parameter id="vAqAaoClJkCs4Z0BwCvX_Q" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_tes" isDefault="1" displayUnit="cm²">
+          <Parameter id="vrIWqsMbUU2dUfi0NKBAGQ" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_hrt" isDefault="1" displayUnit="cm²">
             <Tags>
               <Tag value="Neighborhood: Interstitial / Intracellular" />
             </Tags>
-            <Info min="0" flag="122" seq="4" ref="0" bb="32" group="105" />
+            <Info min="0" flag="122" seq="5" ref="0" bb="32" group="105" />
           </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="h1-Ms5l9r0mK10ga7SMKIw" name="Gonads_bc_VenousBlood_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="4ljY8xwxP0K1LdmospwNkg" secondNeighbor="H3YIKhsT9kW_XjjpUkxqNg">
-        <Tags>
-          <Tag value="Neighborhood: BloodCells / BloodCells" />
-        </Tags>
-        <Children>
-          <Container id="3nP9HzyOA0SgnpMX4EmWVQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
-        </Children>
-      </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="y7AIe-ubgkGSzQZextcd9Q" name="Heart_pls_VenousBlood_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="H8M1nNf2m0a9F4rb9_ggMg" secondNeighbor="dt7fUpCxbUGcr9pNef8UCA">
+      <NeighborhoodBuilder id="IH8EFlq8n0Os8DtpBZB93A" name="Heart_pls_Heart_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="rFnDWJlNa0G4wgk2Zt7Iew" secondNeighbor="lyEOfc6nTEC9WU3_HrdsZw">
         <Tags>
-          <Tag value="Neighborhood: Plasma / Plasma" />
+          <Tag value="Neighborhood: Plasma / BloodCells" />
         </Tags>
         <Children>
-          <Container id="mH4bE8kCV0uzhC3gGF4sQw" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="l36szESkb0abPK_qZ7eONw" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Parameter id="9_b_qczh8Ua0azlBwSEMJA" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" isDefault="1" displayUnit="cm²">
+            <Tags>
+              <Tag value="Neighborhood: Plasma / BloodCells" />
+            </Tags>
+            <Info min="0" flag="122" seq="7" ref="0" bb="32" group="104" />
+          </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="1PtnJ5oU5EGENm1u5Zc27w" name="Heart_pls_Heart_int" mode="Logical" containerType="Neighborhood" firstNeighbor="H8M1nNf2m0a9F4rb9_ggMg" secondNeighbor="twepZykjskmnRGWO-2aUlQ">
+      <NeighborhoodBuilder id="bKsActqs50KGDTEJIl9YaA" name="Heart_pls_Heart_int" mode="Logical" containerType="Neighborhood" firstNeighbor="rFnDWJlNa0G4wgk2Zt7Iew" secondNeighbor="2tAQOA4XtkG3JwwJMnB6ww">
         <Tags>
           <Tag value="Neighborhood: Plasma / Interstitial" />
         </Tags>
         <Children>
-          <Container id="MWCJCetWR0qcvC-OG-5mdg" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="FcZJqdd5-EqCwj7AFS48Tw" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="OCLD66guMEq3W254qbZ44w" name="P (plasma&lt;-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
-                <ValueOrigin id="49" method="Assumption" description="TODO: Default: very fast exchange" />
+              <Parameter id="B-o2lAJzok6enEBr7oPpXg" name="P (plasma&lt;-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
+                <ValueOrigin id="49" source="Other" method="Assumption" description="Assumption: very fast exchange" />
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="77" />
               </Parameter>
-              <Parameter id="Tejxn4CSw0q_uBkliPTsag" name="Partition coefficient (interstitial/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" isDefault="1">
+              <Parameter id="pEgrhuXKKkyuQ8GAMx4sZw" name="Partition coefficient (interstitial/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" isDefault="1">
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="70" />
               </Parameter>
             </Children>
           </Container>
-          <Parameter id="Al0eErEGTECB2IxKci9pAA" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" isDefault="1" displayUnit="cm²">
+          <Parameter id="1PYGs28dw02zm-NGlhTFKQ" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" isDefault="1" displayUnit="cm²">
             <Tags>
               <Tag value="Neighborhood: Plasma / Interstitial" />
             </Tags>
@@ -14482,218 +14610,258 @@
           </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="x909ReruT0efjfpM7iZC9g" name="Heart_bc_VenousBlood_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="5AJyK0UHXEO94cjTdHGfDg" secondNeighbor="H3YIKhsT9kW_XjjpUkxqNg">
+      <NeighborhoodBuilder id="pbrzqXeIOE-_DgeL0W50vQ" name="Heart_pls_VenousBlood_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="rFnDWJlNa0G4wgk2Zt7Iew" secondNeighbor="Ans5EKfuF0W1dnzkXjqTlg">
+        <Tags>
+          <Tag value="Neighborhood: Plasma / Plasma" />
+        </Tags>
+        <Children>
+          <Container id="WCo8gvlrJkSseNLCuGcmWQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="pl8S0Yzu606y3KBpqrKX3A" name="Kidney_bc_VenousBlood_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="BrFx5lvTtUGAhE-smnAxbA" secondNeighbor="bHtbzf2QTkS9BPP8ck7mNg">
         <Tags>
           <Tag value="Neighborhood: BloodCells / BloodCells" />
         </Tags>
         <Children>
-          <Container id="Mh-tFe_QVkKCyOxHhuozxQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="mrgCnuOW0UGOOWdxBGD6iQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="n2cLvrmEiEmZJOf7DjJCBA" name="Heart_int_Heart_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="twepZykjskmnRGWO-2aUlQ" secondNeighbor="MT5-katxiUS30H6cHWz16A">
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+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="78" />
+              </Parameter>
+              <Parameter id="B8VRBfQm_US9fgTSKWo_bA" name="P (intracellular-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" isDefault="1" displayUnit="cm/min">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="76" />
+              </Parameter>
+              <Parameter id="zOaYswFfmUmb3KkDrPgDfg" name="P*SA interstitial -&gt; intracellular" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" isDefault="1" displayUnit="l/min">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="fI5TXIxTqEaYzRUWrn9pog" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
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+              <Parameter id="MMhKZ5f-XUa7UTNLCD9PzQ" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
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+              <Parameter id="BKG3P3d_m0mI7urm-ES-Sg" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
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+              <Parameter id="lFMpZtzv-kiIVoZVUsALkg" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="69" />
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+              <Parameter id="0ONhFoik4E62si8aec-tXg" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
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+          <Parameter id="F-4HrcBZRE6KfAFw3x7tgg" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_kid" isDefault="1" displayUnit="cm²">
             <Tags>
               <Tag value="Neighborhood: Interstitial / Intracellular" />
             </Tags>
-            <Info min="0" flag="122" seq="5" ref="0" bb="32" group="105" />
+            <Info min="0" flag="122" seq="6" ref="0" bb="32" group="105" />
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-      <NeighborhoodBuilder id="TxPY32FsGECY_7xjg7Uczw" name="Heart_pls_Heart_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="H8M1nNf2m0a9F4rb9_ggMg" secondNeighbor="5AJyK0UHXEO94cjTdHGfDg">
+      <NeighborhoodBuilder id="cPQ7TYGQ9k-H__fCS-K4jw" name="Kidney_cell_Kidney_ur" mode="Logical" containerType="Neighborhood" firstNeighbor="8Y6EVjFoqEmjiDi4BEwtgQ" secondNeighbor="3F0-FJLEU0-S4f5_pji2aw">
+        <Tags>
+          <Tag value="Neighborhood: Intracellular / Urine" />
+        </Tags>
+        <Children>
+          <Container id="D3E15s-7F0iRbjyFAizpfw" name="MoleculeProperties" mode="Logical" containerType="Other">
+            <Children>
+              <Parameter id="wehFtQDu50qsaqDQi61S4Q" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_water_cell_Kidney" isDefault="1">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+              </Parameter>
+            </Children>
+          </Container>
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="Gyq9SNb61U68uqaTuCQiNQ" name="Kidney_pls_Kidney_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="IbVvFDyOgESWto1vT-yhTA" secondNeighbor="BrFx5lvTtUGAhE-smnAxbA">
         <Tags>
           <Tag value="Neighborhood: Plasma / BloodCells" />
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+          <Container id="j2_Zx0jsfEKhciNk7f4tqg" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Parameter id="I39S4Erzu02MpEhyDXAI7A" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" isDefault="1" displayUnit="cm²">
             <Tags>
               <Tag value="Neighborhood: Plasma / BloodCells" />
             </Tags>
-            <Info min="0" flag="122" seq="7" ref="0" bb="32" group="104" />
+            <Info min="0" flag="122" seq="8" ref="0" bb="32" group="104" />
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-      <NeighborhoodBuilder id="_nWjnegthUGKQ45a-DqRyw" name="Kidney_bc_VenousBlood_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="1x_51LttQkWUODbCgb2mkA" secondNeighbor="H3YIKhsT9kW_XjjpUkxqNg">
+      <NeighborhoodBuilder id="VWIkJ9o760K2EvCc3bExAA" name="Kidney_pls_Kidney_int" mode="Logical" containerType="Neighborhood" firstNeighbor="IbVvFDyOgESWto1vT-yhTA" secondNeighbor="MPgIXNyqo0qosyQtvRmg_Q">
         <Tags>
-          <Tag value="Neighborhood: BloodCells / BloodCells" />
+          <Tag value="Neighborhood: Plasma / Interstitial" />
+        </Tags>
+        <Children>
+          <Container id="YgOsM3nLBkyTLEvVg5-vpQ" name="MoleculeProperties" mode="Logical" containerType="Other">
+            <Children>
+              <Parameter id="T5ID2E70mkmknoTqejtvgQ" name="P (plasma&lt;-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
+                <ValueOrigin id="49" source="Other" method="Assumption" description="Assumption: very fast exchange" />
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="77" />
+              </Parameter>
+              <Parameter id="dt5FoE7SOUSxWn2GTwBjdw" name="Partition coefficient (interstitial/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" isDefault="1">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="70" />
+              </Parameter>
+            </Children>
+          </Container>
+          <Parameter id="bTSV-Z5lEEKFZEyFvvpcxA" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" isDefault="1" displayUnit="cm²">
+            <Tags>
+              <Tag value="Neighborhood: Plasma / Interstitial" />
+            </Tags>
+            <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+            <Info min="0" flag="122" seq="6" ref="0" bb="32" group="106" />
+          </Parameter>
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="0cM43dsnN0mCUac2FSfK8A" name="Kidney_pls_Kidney_ur" mode="Logical" containerType="Neighborhood" firstNeighbor="IbVvFDyOgESWto1vT-yhTA" secondNeighbor="3F0-FJLEU0-S4f5_pji2aw">
+        <Tags>
+          <Tag value="Neighborhood: Plasma / Urine" />
         </Tags>
         <Children>
-          <Container id="S2_DfZenfEq6ytC8Pij21w" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="bkyCj7GswESY5k4pZuIR_Q" name="MoleculeProperties" mode="Logical" containerType="Other" />
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-      <NeighborhoodBuilder id="wReC_oxP7UKwhwQ_7II11w" name="UpperJejunum_pls_PortalVein_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="zSjCQfE2ukibuVnEq9IN8w" secondNeighbor="meWL4gPZR0uFouhVl8UsOw">
+      <NeighborhoodBuilder id="1UehtimYl0ynLNEZSZdOMA" name="Kidney_pls_VenousBlood_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="IbVvFDyOgESWto1vT-yhTA" secondNeighbor="Ans5EKfuF0W1dnzkXjqTlg">
         <Tags>
           <Tag value="Neighborhood: Plasma / Plasma" />
         </Tags>
         <Children>
-          <Container id="3iwFqs89NUeDynxa2ccOYA" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="4ep6wX9EGUWIGshTvGi56g" name="MoleculeProperties" mode="Logical" containerType="Other" />
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="fhCBcli-6kWvDfKROVt_Yg" name="Lumen_uje_UpperJejunum_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="nG2AxthZukKU2Jjz7hjFcQ" secondNeighbor="4CbOfy3paECKcKT3NoWL2w">
+        <Tags>
+          <Tag value="Neighborhood: UpperJejunum / Plasma" />
+        </Tags>
+        <Children>
+          <Container id="-fpjWYSQlkWKpfnGysiNvw" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="DYjgTAFfnESN8GMx1gWgbw" name="Mass transfer rate (mucosa to portal vein plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPvePlasma" isDefault="1" displayUnit="µmol/min">
-                <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+              <Parameter id="888HqbE53ka3ltf0d6nKRA" name="Drug absorption rate (lumen to mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_DrugAbsorption_para" isDefault="1" displayUnit="µmol/min">
                 <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
               </Parameter>
+              <Parameter id="G06hcd5KWEWDkZfFiBGDmw" name="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" isDefault="1" displayUnit="µmol/min">
+                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
+              <Parameter id="qY61EObbJ0m3ITlXJ4dDMA" name="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" isDefault="1" displayUnit="µmol/min">
+                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
             </Children>
           </Container>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="pt6oCzDY9EG4PmiMrvnXfA" name="Lumen_uje_UpperJejunum_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="_WvzIfMtH0mN7r4XQbGfAg" secondNeighbor="CcO7OCe_ME-7FudeoxVNtA">
+      <NeighborhoodBuilder id="ZiILhRI5qUu5271BFf6Bog" name="Lumen_uje_UpperJejunum_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="nG2AxthZukKU2Jjz7hjFcQ" secondNeighbor="sydFGAeVT0OsnWNbGigz6A">
         <Tags>
           <Tag value="Neighborhood: UpperJejunum / Intracellular" />
         </Tags>
         <Children>
-          <Container id="nYIkNUVkKEW53EiJaPolAg" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="7b8wr5QDbkys7JFpBQ2bKA" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="rYc_Y27MJEWvTd8lQOsAig" name="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" isDefault="1" displayUnit="µmol/min">
-                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+              <Parameter id="NAnRgGM-40GeKj8aPseiRA" name="Drug absorption rate (lumen to mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_DrugAbsorption_trans" isDefault="1" displayUnit="µmol/min">
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
               </Parameter>
-              <Parameter id="5TIcRdOPjEq_h8H3o1F7Mw" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K8" isDefault="1">
+              <Parameter id="GejUmykeLUa2qUjCN-x-SA" name="P_int_trans_cell_lum_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_cell_lum_factor" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
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-                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
-              </Parameter>
-              <Parameter id="ugh4jDenz0SF28Sk40r8CQ" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F2" isDefault="1">
+              <Parameter id="6ZRhfXSmrkKjSUy6EgehAw" name="P_int_trans_lum_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_lum_cell_factor" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="5LWIYeFX8Ei0jjvftSzAQw" name="pKa_pH_WS_cell_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F3" isDefault="1">
-                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              <Parameter id="MMg6gUzejkKvkPlFpcO3DA" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_K_cell_pls_UpperJejunum" isDefault="1">
+                <Info min="0" flag="36" seq="1" ref="0" bb="2" group="67" />
               </Parameter>
-              <Parameter id="Aubp0PA9D0aShYqxuiETpA" name="pKa_pH_WS_cell_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K1" isDefault="1">
-                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              <Parameter id="vuDZfAf88kuB-UAngHQcrg" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_UpperJejunum" isDefault="1">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
               </Parameter>
-              <Parameter id="J7hojVIEak6gt6Ek_Mz-OQ" name="pKa_pH_WS_cell_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K2" isDefault="1">
+              <Parameter id="UGjWCYnnE0-g6ll-5UVMbg" name="pKa_pH_WS_cell_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F1" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="fV_iRmkeiUSHszdtNvP6cw" name="pKa_pH_WS_cell_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K3" isDefault="1">
+              <Parameter id="vS4HE1zlkESetyvMT7q0yA" name="pKa_pH_WS_cell_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F2" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="eYhq1RfLwUqZKunbHzoxOQ" name="pKa_pH_WS_cell_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K4" isDefault="1">
+              <Parameter id="y3wWZOp-XUeqAgDieYu8Rg" name="pKa_pH_WS_cell_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F3" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="Ok7AWZ4mPkSACATvd3AJSg" name="pKa_pH_WS_cell_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K5" isDefault="1">
+              <Parameter id="vHJMNX0TeEOFckgIBgNJbg" name="pKa_pH_WS_cell_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K1" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="i1bB2XCZCUyrk9Ggtsf7Ig" name="pKa_pH_WS_cell_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K6" isDefault="1">
+              <Parameter id="cH5r81K8P02WzIHUvk4FKQ" name="pKa_pH_WS_cell_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K2" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="MsGH2vZVHUGTDAXGFLclHg" name="pKa_pH_WS_cell_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K7" isDefault="1">
+              <Parameter id="aUUdeg6pJ0yf7oWiomkxCg" name="pKa_pH_WS_cell_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K3" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="YDcvrpmVoE-rcGEUCaQd3w" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F1" isDefault="1">
+              <Parameter id="0Gfi23j6M0-5nop1dMYr6A" name="pKa_pH_WS_cell_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K4" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="3dc482Uy7kydVkQ3tuP0zg" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_UpperJejunum" isDefault="1">
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
-              </Parameter>
-              <Parameter id="eojc9Zep_kqIIr5SZCT0fg" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F3" isDefault="1">
+              <Parameter id="7-ujXjMc2USZwPFPr5PhqA" name="pKa_pH_WS_cell_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K5" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="P1pnuFrWj02K7unBK-Q9Ng" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K1" isDefault="1">
+              <Parameter id="e-WgM8vt7UOKIy505Y3SUQ" name="pKa_pH_WS_cell_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K6" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="sXj348UB1k-DbqMqasZwdw" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K2" isDefault="1">
+              <Parameter id="YQRmpxYrJkKiRj0zoWRbnw" name="pKa_pH_WS_cell_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K7" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="LMGKDlDEwkinuMBBeCcBQw" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K3" isDefault="1">
+              <Parameter id="12HpairtzEabcv5jHNADdg" name="pKa_pH_WS_cell_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K8" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="hSC0dYFUc06PaQfTydyPKQ" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K4" isDefault="1">
+              <Parameter id="er_ggon7SUiuy-qz97Stqw" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F1" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="PH-eUxUrl0K8iyOyKOe4BQ" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K5" isDefault="1">
+              <Parameter id="U-2LMZJq6kGcWgXCND6Law" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F2" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="rBHL1zgubU2P3albXFuSbA" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K6" isDefault="1">
+              <Parameter id="FxbN2D0p9UKWYGt81aPQYA" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F3" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="LRAyeWHJCkC59_u8zBtNIA" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K7" isDefault="1">
+              <Parameter id="sq6_bX3ukE60PkOzRuZFrg" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K1" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="nVbdGvFWTUG7un1CelGyBA" name="pKa_pH_WS_cell_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K8" isDefault="1">
+              <Parameter id="2z4azN0iQU2dMn5RurPpuw" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K2" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="BI4uoKP_Y0ytK6bpBaEkSQ" name="pKa_pH_WS_cell_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F2" isDefault="1">
+              <Parameter id="2-_VMa96E0uioyO1-V9hJA" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K3" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="AWLmP2iSZEy3fT02HUhl7g" name="pKa_pH_WS_cell_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F1" isDefault="1">
+              <Parameter id="X0-c3JRlcEeIKZOeupJqBw" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K4" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="grofyr_YPUm5EqqYFoOqmQ" name="Drug absorption rate (lumen to mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_DrugAbsorption_trans" isDefault="1" displayUnit="µmol/min">
-                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
-              </Parameter>
-              <Parameter id="46lNCcCZfk2MQDBwOY7yQw" name="P_int_trans_cell_lum_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_cell_lum_factor" isDefault="1">
+              <Parameter id="DchdxlXLp0KSxPp5vD41og" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K5" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="NOTTCqP2B0qGSfGYMn18RA" name="P_int_trans_lum_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_lum_cell_factor" isDefault="1">
+              <Parameter id="wPE71zL9N0WD99D5g9hyNQ" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K6" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="p6huzu3w7UORipk_y4XXVQ" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_K_cell_pls_UpperJejunum" isDefault="1">
-                <Info min="0" flag="36" seq="1" ref="0" bb="2" group="67" />
+              <Parameter id="wSIXDgCsgEW8fxFN_PgUOw" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K7" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-            </Children>
-          </Container>
-        </Children>
-      </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="0ZtUiTL_8Eew3c97HULgrw" name="Lumen_uje_UpperJejunum_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="_WvzIfMtH0mN7r4XQbGfAg" secondNeighbor="zSjCQfE2ukibuVnEq9IN8w">
-        <Tags>
-          <Tag value="Neighborhood: UpperJejunum / Plasma" />
-        </Tags>
-        <Children>
-          <Container id="GzdtXn2qpUK9Y_Df5jIo2A" name="MoleculeProperties" mode="Logical" containerType="Other">
-            <Children>
-              <Parameter id="ZYT2Oq7YN0-I5i5qtA9mxA" name="Drug absorption rate (lumen to mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_DrugAbsorption_para" isDefault="1" displayUnit="µmol/min">
-                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+              <Parameter id="J56qi3UolkumRc8qhzp5rw" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K8" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="oCWzplejsUmp-LxFUj4c4g" name="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" isDefault="1" displayUnit="µmol/min">
+              <Parameter id="PlNTFtR2mUK4UEca5V3xNQ" name="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" isDefault="1" displayUnit="µmol/min">
                 <Info flag="52" seq="1" ref="0" bb="2" group="117" />
               </Parameter>
-              <Parameter id="Xls1GHkkiE-O2q7JYiSjPg" name="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" isDefault="1" displayUnit="µmol/min">
+              <Parameter id="CcKxFLg1qEyq5vIcPy3IoQ" name="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" isDefault="1" displayUnit="µmol/min">
                 <Info flag="52" seq="1" ref="0" bb="2" group="117" />
               </Parameter>
             </Children>
           </Container>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="7A-tTvB_vUiJzQiZiNQTaw" name="UpperJejunum_bc_PortalVein_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="r_MPzXq0uk2PEXKKnd-O8w" secondNeighbor="-ce4W1W9u0-sDuce1ufJ_A">
+      <NeighborhoodBuilder id="sGWsyel1mU-_xmVQbNL9eg" name="UpperJejunum_pls_PortalVein_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="4CbOfy3paECKcKT3NoWL2w" secondNeighbor="vihskj6fJkaqqVik0r1DIg">
         <Tags>
-          <Tag value="Neighborhood: BloodCells / BloodCells" />
+          <Tag value="Neighborhood: Plasma / Plasma" />
         </Tags>
         <Children>
-          <Container id="THGJJlG2k02pkaEZNYRocg" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="E8On3ET57Eigi0OPKHCu4A" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="LeKlJX5SBUeJja-AZ9rx6g" name="Mass transfer rate (mucosa to portal vein blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPveBloodCells" isDefault="1" displayUnit="µmol/min">
+              <Parameter id="49xFVesE1Ue2PtnP1_USVg" name="Mass transfer rate (mucosa to portal vein plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPvePlasma" isDefault="1" displayUnit="µmol/min">
                 <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                 <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
               </Parameter>
@@ -14701,400 +14869,313 @@
           </Container>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="fk3KtKOdokKtZL1hXbS_fw" name="Kidney_cell_Kidney_ur" mode="Logical" containerType="Neighborhood" firstNeighbor="e29IxhujBkyWy3T1E7lgZw" secondNeighbor="7ijrxaKvTE-h8IMoZRddOA">
-        <Tags>
-          <Tag value="Neighborhood: Intracellular / Urine" />
-        </Tags>
-        <Children>
-          <Container id="y803UJXVUkaTle78ILRsfA" name="MoleculeProperties" mode="Logical" containerType="Other">
-            <Children>
-              <Parameter id="IKgkt244vk6lYC4JN9OHgg" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_water_cell_Kidney" isDefault="1">
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
-              </Parameter>
-            </Children>
-          </Container>
-        </Children>
-      </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="o3sVARN79EO2uev9Ckvs2Q" name="Kidney_pls_Kidney_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="YunXrm_uA0GVV6ozN-56Xw" secondNeighbor="1x_51LttQkWUODbCgb2mkA">
-        <Tags>
-          <Tag value="Neighborhood: Plasma / BloodCells" />
-        </Tags>
-        <Children>
-          <Container id="MBxBpWKq-EGwzZaU496AoA" name="MoleculeProperties" mode="Logical" containerType="Other" />
-          <Parameter id="pYcGTCwLikaDOf5UXRc9tA" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" isDefault="1" displayUnit="cm²">
-            <Tags>
-              <Tag value="Neighborhood: Plasma / BloodCells" />
-            </Tags>
-            <Info min="0" flag="122" seq="8" ref="0" bb="32" group="104" />
-          </Parameter>
-        </Children>
-      </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="y_3tLQEsh0euccj-I64_Rw" name="Kidney_pls_Kidney_int" mode="Logical" containerType="Neighborhood" firstNeighbor="YunXrm_uA0GVV6ozN-56Xw" secondNeighbor="-lLRMLxBgUaEHr61uidqtQ">
+      <NeighborhoodBuilder id="-O5pPUiV1USTJLdMLCavug" name="UpperJejunum_bc_PortalVein_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="2tcy-Ya4DkapvK5NMu6LXQ" secondNeighbor="eN7tQLMOREG3-_sYJSczng">
         <Tags>
-          <Tag value="Neighborhood: Plasma / Interstitial" />
+          <Tag value="Neighborhood: BloodCells / BloodCells" />
         </Tags>
         <Children>
-          <Container id="ex4rBQEDbUWc2_VFY3oogw" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="ZfVeuOdSokSHsdXZik84ww" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="96L0zrcnm0qPhL_sDkJzzg" name="P (plasma&lt;-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
-                <ValueOrigin id="49" method="Assumption" description="TODO: Default: very fast exchange" />
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="77" />
-              </Parameter>
-              <Parameter id="tJs7xV8rq0-LvSg4X1hIvg" name="Partition coefficient (interstitial/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" isDefault="1">
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="70" />
+              <Parameter id="cRvo4-cdYUuB_-Q2A5WZpA" name="Mass transfer rate (mucosa to portal vein blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPveBloodCells" isDefault="1" displayUnit="µmol/min">
+                <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
               </Parameter>
             </Children>
           </Container>
-          <Parameter id="9hxRAp-w7Eq81dcoDEOdaA" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" isDefault="1" displayUnit="cm²">
-            <Tags>
-              <Tag value="Neighborhood: Plasma / Interstitial" />
-            </Tags>
-            <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-            <Info min="0" flag="122" seq="6" ref="0" bb="32" group="106" />
-          </Parameter>
-        </Children>
-      </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="lmwBapjYM0-_QDDABLhCig" name="Kidney_pls_Kidney_ur" mode="Logical" containerType="Neighborhood" firstNeighbor="YunXrm_uA0GVV6ozN-56Xw" secondNeighbor="7ijrxaKvTE-h8IMoZRddOA">
-        <Tags>
-          <Tag value="Neighborhood: Plasma / Urine" />
-        </Tags>
-        <Children>
-          <Container id="F9gSrqlnBU26RAoaGEnAaQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
-        </Children>
-      </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="Aov6KD3F70-hLPHiTLGxqQ" name="Kidney_pls_VenousBlood_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="YunXrm_uA0GVV6ozN-56Xw" secondNeighbor="dt7fUpCxbUGcr9pNef8UCA">
-        <Tags>
-          <Tag value="Neighborhood: Plasma / Plasma" />
-        </Tags>
-        <Children>
-          <Container id="PV_v-YCFJUCaaYvHofqbMA" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="3aBKhmgQukuo5L-adpTSqg" name="Kidney_int_Kidney_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="-lLRMLxBgUaEHr61uidqtQ" secondNeighbor="e29IxhujBkyWy3T1E7lgZw">
+      <NeighborhoodBuilder id="rPHdeeSvtk6lZJjpqDGJ3w" name="Lumen_lje_LowerJejunum_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="Cc6q_6QFp0iNzXJMnzp5vQ" secondNeighbor="_vxo4wcBG0Spf1REJOKECA">
         <Tags>
-          <Tag value="Neighborhood: Interstitial / Intracellular" />
+          <Tag value="Neighborhood: LowerJejunum / Plasma" />
         </Tags>
         <Children>
-          <Container id="AD-MPQQ3LkOiy-FhNmUmjA" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="X1lKGhOztk-FiCcf1nLbBQ" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="Wvnc3iivxUO43y7KN4Ku2Q" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
-              </Parameter>
-              <Parameter id="UE3d37dX80-pDHGRoMx1Jw" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
-              </Parameter>
-              <Parameter id="pmByWGH4t0uyq7zrx234ZQ" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
-              </Parameter>
-              <Parameter id="E8VI6OpkVUaHWDD__hR5mg" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="69" />
-              </Parameter>
-              <Parameter id="25WqX0Z5nEyTXoQpCWwUMw" name="P (interstitial-&gt;intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" isDefault="1" displayUnit="cm/min">
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="78" />
-              </Parameter>
-              <Parameter id="8J3yqxf0ZEi54EjRyjJB8w" name="P (intracellular-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" isDefault="1" displayUnit="cm/min">
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="76" />
+              <Parameter id="i9dRtJbToUq9jpemLL_43A" name="Drug absorption rate (lumen to mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_DrugAbsorption_para" isDefault="1" displayUnit="µmol/min">
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
               </Parameter>
-              <Parameter id="Jhf374WD102AnORxiHXPSA" name="P*SA interstitial -&gt; intracellular" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" isDefault="1" displayUnit="l/min">
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+              <Parameter id="vukSeZP5R0GNu5Y1Ec2Idg" name="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" isDefault="1" displayUnit="µmol/min">
+                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
               </Parameter>
-              <Parameter id="xidQ1xpjTEmfI9SpAoH0Vw" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+              <Parameter id="GlbRh7zJC0Slh7U9SHDGow" name="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" isDefault="1" displayUnit="µmol/min">
+                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
               </Parameter>
             </Children>
           </Container>
-          <Parameter id="Polk9wASa0GQZrTQgUISRw" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_kid" isDefault="1" displayUnit="cm²">
-            <Tags>
-              <Tag value="Neighborhood: Interstitial / Intracellular" />
-            </Tags>
-            <Info min="0" flag="122" seq="6" ref="0" bb="32" group="105" />
-          </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="8HKb8690SUC3LJov-mPtSA" name="Lumen_lje_LowerJejunum_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="kkxzQN9__kSp5W5wsE_IgA" secondNeighbor="7dlPgIDV3kmO0AMYM-CWrQ">
+      <NeighborhoodBuilder id="poH9rq55tkS-nLqupS75OQ" name="Lumen_lje_LowerJejunum_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="Cc6q_6QFp0iNzXJMnzp5vQ" secondNeighbor="ZVzsDd2s6USCvF5KFRacyQ">
         <Tags>
           <Tag value="Neighborhood: LowerJejunum / Intracellular" />
         </Tags>
         <Children>
-          <Container id="hGqk4SI74kmeU4tcsCkj6g" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="QpcuiiS4y0aAIOzThaiEqg" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="kQQT8YmedkOnO1G7VR57wQ" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K2" isDefault="1">
-                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              <Parameter id="vkHBpN7_pEy6Z_3whZLm9w" name="Drug absorption rate (lumen to mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_DrugAbsorption_trans" isDefault="1" displayUnit="µmol/min">
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
               </Parameter>
-              <Parameter id="V6P5X90b2k2JnfsHgxY1gQ" name="pKa_pH_WS_cell_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K3" isDefault="1">
+              <Parameter id="ADcIX9qGREufbaJjXCLRtw" name="P_int_trans_cell_lum_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_cell_lum_factor" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="TbrdPBrYhU2DfTq4Fb7HAg" name="pKa_pH_WS_cell_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K4" isDefault="1">
+              <Parameter id="TkWDSK3qvkm8SZwxERI8tg" name="P_int_trans_lum_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_lum_cell_factor" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="7IW3j6UgAUOuOumPN9YiwA" name="pKa_pH_WS_cell_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K5" isDefault="1">
-                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              <Parameter id="czyUyXPqdE2ZkXEu4cu_sg" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_K_cell_pls_LowerJejunum" isDefault="1">
+                <Info min="0" flag="36" seq="1" ref="0" bb="2" group="67" />
               </Parameter>
-              <Parameter id="r0AZmo6ZcEuC62PhV_wSoQ" name="pKa_pH_WS_cell_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K6" isDefault="1">
-                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              <Parameter id="KglmsCiVJ0mSZ8z-vCQH_A" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_LowerJejunum" isDefault="1">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
               </Parameter>
-              <Parameter id="80axzjgajEmTaJhDUKPrAA" name="pKa_pH_WS_cell_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K7" isDefault="1">
+              <Parameter id="kKkV4auq2kOT6Ihfege-6A" name="pKa_pH_WS_cell_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F1" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="QLQESVdvhESJITyy8aXZZA" name="pKa_pH_WS_cell_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K8" isDefault="1">
+              <Parameter id="Rr5TDXSXukCk0yoZxEL5cw" name="pKa_pH_WS_cell_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F2" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="isgvfhISkkON71fULxjg2Q" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F1" isDefault="1">
+              <Parameter id="bRketR0uhkWmmsyIJkJu-g" name="pKa_pH_WS_cell_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F3" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="7NK_3qyjxkGvcXF8gZqv_Q" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F2" isDefault="1">
+              <Parameter id="fDj98vNGD0q3vSb7GA9miA" name="pKa_pH_WS_cell_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K1" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="ltda_ecIlEykAxvZeBBK8A" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K1" isDefault="1">
+              <Parameter id="ppxMnofmxUytbXvGaaLI6g" name="pKa_pH_WS_cell_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K2" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="Nw0BsV7pM0u4v8VmBY6fDg" name="pKa_pH_WS_cell_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F3" isDefault="1">
+              <Parameter id="u3a0I_CVY0yOpym7bAxQ9w" name="pKa_pH_WS_cell_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K3" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="qDn1UX4BpUa70o1vmsorYg" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K3" isDefault="1">
+              <Parameter id="7fxRrwTolUOxZ5gYGxSU0g" name="pKa_pH_WS_cell_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K4" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="bgA68ZGw0kG2f5Xz6bZu5g" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K4" isDefault="1">
+              <Parameter id="xMWWCDB0YEe64nz1O-AGIw" name="pKa_pH_WS_cell_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K5" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="6ikQkBbqi0aulWK1o5Pwmg" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K5" isDefault="1">
+              <Parameter id="eEDvDQP-EkeqHX7UVPXDCg" name="pKa_pH_WS_cell_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K6" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="Jp56MI66s0GygF8VGwtWaA" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K6" isDefault="1">
+              <Parameter id="mAnUr7ILC0iYz3X8VzigOw" name="pKa_pH_WS_cell_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K7" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="78SK5_Va3UyucMrtjI3nYA" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K7" isDefault="1">
+              <Parameter id="qT0rMjWVqkWs6y1xyMZuow" name="pKa_pH_WS_cell_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K8" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="L0WM5XuWQEiRVbt3AhJU1g" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K8" isDefault="1">
+              <Parameter id="ur4GszpzIkOF6sjc8kipIw" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F1" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="leP3hj1YDEe05ljALxb6Xw" name="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" isDefault="1" displayUnit="µmol/min">
-                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
-              </Parameter>
-              <Parameter id="VHB43SSPUEi93it--W4Icw" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F3" isDefault="1">
+              <Parameter id="HaZF8kKYE0y6cRE9ZBtPMw" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F2" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="iSRRILdNxU6XkOTEmbFO1Q" name="pKa_pH_WS_cell_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K2" isDefault="1">
+              <Parameter id="AB6PmbtAU0mX798Rv0VOOw" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F3" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="ntizW6pGGkua0LqpD8rb0g" name="pKa_pH_WS_cell_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K1" isDefault="1">
+              <Parameter id="EAkYtLqX_kiYv1CJ0foA0w" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K1" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="qv-i3jTEp0yfwLKUe20xDQ" name="Drug absorption rate (lumen to mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_DrugAbsorption_trans" isDefault="1" displayUnit="µmol/min">
-                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+              <Parameter id="Ot5AkGm7AUSJbkwDsj-6yA" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K2" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="Eb7f-U1Vokax8ebCIJFCzg" name="P_int_trans_cell_lum_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_cell_lum_factor" isDefault="1">
+              <Parameter id="J88GfY6mKkO8yw1H-h0z2A" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K3" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="HFif7wMnA0OPbfq8JZWYVA" name="P_int_trans_lum_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_lum_cell_factor" isDefault="1">
+              <Parameter id="A8wznNkmcUWWQxPXk-bwPg" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K4" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="S7Dc28R4ZEO8si6EOncOjg" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_K_cell_pls_LowerJejunum" isDefault="1">
-                <Info min="0" flag="36" seq="1" ref="0" bb="2" group="67" />
+              <Parameter id="Jkj0WSdb1keq-NggVuWkzA" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K5" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="1bY7EJsrE0SMA3ooUujwnA" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_LowerJejunum" isDefault="1">
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+              <Parameter id="IUO9Fu-Mb0Oe-j3XVVPNXw" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K6" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="bmI9j65zyUeLokEU_B1UqA" name="pKa_pH_WS_cell_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F1" isDefault="1">
+              <Parameter id="QJ8DPtap6ESHLUeFzuO3gg" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K7" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="If-AivzWCUuivfvJQ-2eyw" name="pKa_pH_WS_cell_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F2" isDefault="1">
+              <Parameter id="kiumXJ4zIEiJlm8oybL5tA" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K8" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="Md3xcCkpQUuClH55DW7SUQ" name="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" isDefault="1" displayUnit="µmol/min">
+              <Parameter id="NqoZUJ1Wdku7RgkiQbjR8Q" name="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" isDefault="1" displayUnit="µmol/min">
+                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
+              <Parameter id="h6pg6rXv2E6d7L_nDOoRMQ" name="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" isDefault="1" displayUnit="µmol/min">
                 <Info flag="52" seq="1" ref="0" bb="2" group="117" />
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-      <NeighborhoodBuilder id="q6bylsa2bkmDuG56RmOYUg" name="Lumen_lje_LowerJejunum_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="kkxzQN9__kSp5W5wsE_IgA" secondNeighbor="zrKtW28pvEStr3uQ0NWXgQ">
+      <NeighborhoodBuilder id="Cg8mr5b5p0SiU2rG_131vQ" name="LowerJejunum_pls_PortalVein_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="_vxo4wcBG0Spf1REJOKECA" secondNeighbor="vihskj6fJkaqqVik0r1DIg">
         <Tags>
-          <Tag value="Neighborhood: LowerJejunum / Plasma" />
+          <Tag value="Neighborhood: Plasma / Plasma" />
         </Tags>
         <Children>
-          <Container id="bZ7DtA7S6kaiO7yfKRWCEw" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="Gvmbaz8Vl0SjUQyjoKsvmw" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="reMKMr1gykGMAzNfmC_uLg" name="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" isDefault="1" displayUnit="µmol/min">
-                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
-              </Parameter>
-              <Parameter id="bE_cdktWY0STjTHSHM2Cgw" name="Drug absorption rate (lumen to mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_DrugAbsorption_para" isDefault="1" displayUnit="µmol/min">
+              <Parameter id="IAvE8ckAb0KYa-jwmxYYdQ" name="Mass transfer rate (mucosa to portal vein plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPvePlasma" isDefault="1" displayUnit="µmol/min">
+                <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                 <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
               </Parameter>
-              <Parameter id="T4l1a_ilr0-_W_STg1MnDg" name="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" isDefault="1" displayUnit="µmol/min">
-                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
-              </Parameter>
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       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="O8SYeragxEuECZ6QTmn2ZA" name="Lumen_duo_Lumen_uje" mode="Logical" containerType="Neighborhood" firstNeighbor="R6oHTJqg9kGzj5KJS4zGGg" secondNeighbor="_WvzIfMtH0mN7r4XQbGfAg">
+      <NeighborhoodBuilder id="U-vxXtHuyE663n4zhAkuOw" name="LowerJejunum_bc_PortalVein_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="K659GHjLpkKqC6Y--ONvog" secondNeighbor="eN7tQLMOREG3-_sYJSczng">
         <Tags>
-          <Tag value="Neighborhood: Duodenum / UpperJejunum" />
+          <Tag value="Neighborhood: BloodCells / BloodCells" />
         </Tags>
         <Children>
-          <Container id="x5QN0hsew069whlMYrY06g" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="hoQYMA8SPk6TwhPRWk33BQ" name="MoleculeProperties" mode="Logical" containerType="Other">
+            <Children>
+              <Parameter id="CrzNI9IBAkmjt42KXNd7cQ" name="Mass transfer rate (mucosa to portal vein blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPveBloodCells" isDefault="1" displayUnit="µmol/min">
+                <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+              </Parameter>
+            </Children>
+          </Container>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="Wwi--qjiBEaWs1tYWRtjeQ" name="Lumen_sto_Lumen_duo" mode="Logical" containerType="Neighborhood" firstNeighbor="2UkNT1GrSEGPAlaFowDKXA" secondNeighbor="R6oHTJqg9kGzj5KJS4zGGg">
+      <NeighborhoodBuilder id="0Z6nWE_lO0yI-ZkZvHejog" name="Lumen_sto_Lumen_duo" mode="Logical" containerType="Neighborhood" firstNeighbor="RsslivV9F0iNMAFK3ZSVfw" secondNeighbor="1WeVhpyE0E2FsX9S1BNctw">
         <Tags>
           <Tag value="Neighborhood: Stomach / Duodenum" />
         </Tags>
         <Children>
-          <Container id="5AppfmlG_UukcFCl7xG37w" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="baMn53MRX0ayV2RfFuw1Xg" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="vRtdP5BYJ0yB7rULQJb0UQ" name="Oral mass absorbed" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_OralMassAbsorbed" isDefault="1" displayUnit="µmol">
+              <Parameter id="ITEXnZF54E2z97mv8hAvCQ" name="Oral mass absorbed" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_OralMassAbsorbed" isDefault="1" displayUnit="µmol">
                 <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
               </Parameter>
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       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="B3iIqb4ll0abC6HdMqgfyQ" name="Lumen_uje_Lumen_lje" mode="Logical" containerType="Neighborhood" firstNeighbor="_WvzIfMtH0mN7r4XQbGfAg" secondNeighbor="kkxzQN9__kSp5W5wsE_IgA">
-        <Tags>
-          <Tag value="Neighborhood: UpperJejunum / LowerJejunum" />
-        </Tags>
-        <Children>
-          <Container id="j6hUnlWmyU61K2tY2uhezQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
-        </Children>
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-      <NeighborhoodBuilder id="1E3KBzXNGEyGuAaVNNSCLA" name="Lumen_lje_Lumen_uil" mode="Logical" containerType="Neighborhood" firstNeighbor="kkxzQN9__kSp5W5wsE_IgA" secondNeighbor="ESTEWsLHx0OLfQr-M3hs1A">
+      <NeighborhoodBuilder id="tnicMMrpfUKUQ5OY9LV7tQ" name="Lumen_duo_Lumen_uje" mode="Logical" containerType="Neighborhood" firstNeighbor="1WeVhpyE0E2FsX9S1BNctw" secondNeighbor="nG2AxthZukKU2Jjz7hjFcQ">
         <Tags>
-          <Tag value="Neighborhood: LowerJejunum / UpperIleum" />
+          <Tag value="Neighborhood: Duodenum / UpperJejunum" />
         </Tags>
         <Children>
-          <Container id="ZGA-CIdp9U-9-Li0dL15Ew" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="o4YZUsnKgUqnyiNaSi2TQA" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="puXGTRjKtk-eJ2P5bHsciA" name="LowerJejunum_pls_PortalVein_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="zrKtW28pvEStr3uQ0NWXgQ" secondNeighbor="meWL4gPZR0uFouhVl8UsOw">
+      <NeighborhoodBuilder id="dMS5EKYvgkaydVEtpSIaIw" name="Lumen_uje_Lumen_lje" mode="Logical" containerType="Neighborhood" firstNeighbor="nG2AxthZukKU2Jjz7hjFcQ" secondNeighbor="Cc6q_6QFp0iNzXJMnzp5vQ">
         <Tags>
-          <Tag value="Neighborhood: Plasma / Plasma" />
+          <Tag value="Neighborhood: UpperJejunum / LowerJejunum" />
         </Tags>
         <Children>
-          <Container id="zv4077B2OEKMsa95QR7bzQ" name="MoleculeProperties" mode="Logical" containerType="Other">
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-              <Parameter id="Ywl0ugrILUqDMbzg6bOSRg" name="Mass transfer rate (mucosa to portal vein plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPvePlasma" isDefault="1" displayUnit="µmol/min">
-                <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
-                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
-              </Parameter>
-            </Children>
-          </Container>
+          <Container id="tUJovQD820aHr0cMy2lwNg" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="giAZOcr3dEul5SOFKAKIhw" name="LowerJejunum_bc_PortalVein_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="Wda4ndmPT0GokpTDOLelAw" secondNeighbor="-ce4W1W9u0-sDuce1ufJ_A">
+      <NeighborhoodBuilder id="lcbnSdqdbEW2dPCmNQLRAg" name="Lumen_lje_Lumen_uil" mode="Logical" containerType="Neighborhood" firstNeighbor="Cc6q_6QFp0iNzXJMnzp5vQ" secondNeighbor="sCpNhHJQCEWV2oakLgPUew">
         <Tags>
-          <Tag value="Neighborhood: BloodCells / BloodCells" />
+          <Tag value="Neighborhood: LowerJejunum / UpperIleum" />
         </Tags>
         <Children>
-          <Container id="JJTtn9gXc0iP5OdirGRnlg" name="MoleculeProperties" mode="Logical" containerType="Other">
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-                <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
-                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
-              </Parameter>
-            </Children>
-          </Container>
+          <Container id="o0rK70dARUaGmtR_UP1LyQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="tdpnaYcIzk21U6k8AOQFdA" name="Lumen_uil_Lumen_lil" mode="Logical" containerType="Neighborhood" firstNeighbor="ESTEWsLHx0OLfQr-M3hs1A" secondNeighbor="Lb1SPQ-6FkGtMC4KAGRoSA">
+      <NeighborhoodBuilder id="2TxREB6c6kmukmRh-CAnWQ" name="Lumen_uil_Lumen_lil" mode="Logical" containerType="Neighborhood" firstNeighbor="sCpNhHJQCEWV2oakLgPUew" secondNeighbor="WhhY_lqxWkWM0OtpLodvWw">
         <Tags>
           <Tag value="Neighborhood: UpperIleum / LowerIleum" />
         </Tags>
         <Children>
-          <Container id="PcVLPbp5PEG-MkQ44V8pEA" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="6t7GVX-sAE2FtqiOTw2rlg" name="MoleculeProperties" mode="Logical" containerType="Other" />
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       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="QG57of89PUSDmwjfhA6-gg" name="Lumen_lil_Lumen_cae" mode="Logical" containerType="Neighborhood" firstNeighbor="Lb1SPQ-6FkGtMC4KAGRoSA" secondNeighbor="1Yph3j4_2EWXIUkeJgtkTg">
+      <NeighborhoodBuilder id="HrMBmTPZoE6dVsP7CkG0Vw" name="Lumen_lil_Lumen_cae" mode="Logical" containerType="Neighborhood" firstNeighbor="WhhY_lqxWkWM0OtpLodvWw" secondNeighbor="kGnbkD3u90iwTRcuuGciQQ">
         <Tags>
           <Tag value="Neighborhood: LowerIleum / Caecum" />
         </Tags>
         <Children>
-          <Container id="Mt59UmF-jEyNYcKoa9VrFQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="FJKzx7s1EU-MyhlL4Cudgw" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="64nvDe2MIEugvwEZR7z6ug" name="Lumen_cae_Lumen_colasc" mode="Logical" containerType="Neighborhood" firstNeighbor="1Yph3j4_2EWXIUkeJgtkTg" secondNeighbor="ATNjWx7V7keoPmoUq2XmTQ">
+      <NeighborhoodBuilder id="KxfSut4NfECugLUPb9ovPA" name="Lumen_cae_Lumen_colasc" mode="Logical" containerType="Neighborhood" firstNeighbor="kGnbkD3u90iwTRcuuGciQQ" secondNeighbor="B6U75mASo02V01eMygYROA">
         <Tags>
           <Tag value="Neighborhood: Caecum / ColonAscendens" />
         </Tags>
         <Children>
-          <Container id="VTfLEx8wa0efCY6nTT5UFg" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="HuQDukBobkCWvHteqkpmrA" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="4e1zmjQeukqWCnV5G7nSnQ" name="Lumen_colasc_Lumen_coltrans" mode="Logical" containerType="Neighborhood" firstNeighbor="ATNjWx7V7keoPmoUq2XmTQ" secondNeighbor="ulKpUIAAi06wltlr56erzQ">
+      <NeighborhoodBuilder id="uoQ6RSk3CEiB1wZMsEWAlA" name="Lumen_colasc_Lumen_coltrans" mode="Logical" containerType="Neighborhood" firstNeighbor="B6U75mASo02V01eMygYROA" secondNeighbor="azrzt6ezxUOsH5qwRQFgow">
         <Tags>
           <Tag value="Neighborhood: ColonAscendens / ColonTransversum" />
         </Tags>
         <Children>
-          <Container id="yJb1YV6qXEWDR2pQCnOe3Q" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="YbQb8dAKMEK5x5DZSET2Zw" name="MoleculeProperties" mode="Logical" containerType="Other" />
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       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="jqkX15sJ30KwHDKNCvTvdQ" name="Lumen_coltrans_Lumen_coldesc" mode="Logical" containerType="Neighborhood" firstNeighbor="ulKpUIAAi06wltlr56erzQ" secondNeighbor="JbHmfXgfJ0agDpPA7oV89g">
+      <NeighborhoodBuilder id="IAxn0_Wp9U6TKjygvvrZzQ" name="Lumen_coltrans_Lumen_coldesc" mode="Logical" containerType="Neighborhood" firstNeighbor="azrzt6ezxUOsH5qwRQFgow" secondNeighbor="PIYPudRTc0ObXI5ZSrWFNg">
         <Tags>
           <Tag value="Neighborhood: ColonTransversum / ColonDescendens" />
         </Tags>
         <Children>
-          <Container id="2mKQL8eXekWC4qiaDUGpcA" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="uUnXEKFNvkepNU5Ysrbifw" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="kgxdoHISeUSn2rtEiQtLyg" name="Lumen_coldesc_Lumen_colsigm" mode="Logical" containerType="Neighborhood" firstNeighbor="JbHmfXgfJ0agDpPA7oV89g" secondNeighbor="IUIlF5c6mEeLyH0-jGRL5g">
+      <NeighborhoodBuilder id="8wqTt48oI06zBmu1_EDVCw" name="Lumen_coldesc_Lumen_colsigm" mode="Logical" containerType="Neighborhood" firstNeighbor="PIYPudRTc0ObXI5ZSrWFNg" secondNeighbor="WT1bl4RAt0mxWQ1qvDeWTQ">
         <Tags>
           <Tag value="Neighborhood: ColonDescendens / ColonSigmoid" />
         </Tags>
         <Children>
-          <Container id="tQXIGIvhTUqvyWyTTXeIOQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="BKBqOzKVh0Styuk_AwwDPQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="1ZHSpqGh_0uWlt4XdrYRhg" name="Lumen_colsigm_Lumen_rect" mode="Logical" containerType="Neighborhood" firstNeighbor="IUIlF5c6mEeLyH0-jGRL5g" secondNeighbor="6fn_3RiggkS4UkuFhro8Dw">
+      <NeighborhoodBuilder id="jXyfIoTOtE-E795HOMVjYg" name="Lumen_colsigm_Lumen_rect" mode="Logical" containerType="Neighborhood" firstNeighbor="WT1bl4RAt0mxWQ1qvDeWTQ" secondNeighbor="UpSKgnWYPEiXklQNAqrFdg">
         <Tags>
           <Tag value="Neighborhood: ColonSigmoid / Rectum" />
         </Tags>
         <Children>
-          <Container id="Yuy2PiI67EifiUZGzcfT9w" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="yiicApgGeEqmwg6-0zUWAg" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="wHbbpz6r8km0dtKXdJd40w" name="Lumen_rect_Lumen_fec" mode="Logical" containerType="Neighborhood" firstNeighbor="6fn_3RiggkS4UkuFhro8Dw" secondNeighbor="fC_ON9xUFUeYD0_p8R-LbQ">
+      <NeighborhoodBuilder id="w7h9UqAjt0qj7Hyf_hdDwA" name="Lumen_rect_Lumen_fec" mode="Logical" containerType="Neighborhood" firstNeighbor="UpSKgnWYPEiXklQNAqrFdg" secondNeighbor="hjYz-UFsdU-eQOKivi16tA">
         <Tags>
           <Tag value="Neighborhood: Rectum / Feces" />
         </Tags>
         <Children>
-          <Container id="LQTHtR5O3EmgI6f8sNMTUQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="Z2jviXhujUu_mgP2RgSNzA" name="MoleculeProperties" mode="Logical" containerType="Other" />
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="um-6-HaqoEagTKfnFxtLPA" name="Stomach_bc_PortalVein_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="AVrkjZHVYE2BekZ0hnC4Wg" secondNeighbor="eN7tQLMOREG3-_sYJSczng">
+        <Tags>
+          <Tag value="Neighborhood: BloodCells / BloodCells" />
+        </Tags>
+        <Children>
+          <Container id="A37iw36TSUOnKWTaXPSAZA" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="0G_jx9_8RkeCrQhucT1F2Q" name="Stomach_int_Stomach_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="QmDulSYPKUeL8N3K5vwsYQ" secondNeighbor="iTYIG51yM0ihvhyZ_3uPyQ">
+      <NeighborhoodBuilder id="EMOL5gdCgEKOktYsIhnzdQ" name="Stomach_int_Stomach_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="_GvqcoaP4k2UJRR2NiaDGg" secondNeighbor="cE5Vh4PDM0yzMt6k1l_McQ">
         <Tags>
           <Tag value="Neighborhood: Interstitial / Intracellular" />
         </Tags>
         <Children>
-          <Container id="4onK6g-OyUOdIK6Wy8gPJw" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="XbyDO_JPok6IfevC8MlgAw" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="a0ELZv-m1kS8mfMb_EjSPg" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
-              </Parameter>
-              <Parameter id="O-Ix7zA-jk2OvQUrBj2Lpg" name="P (interstitial-&gt;intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" isDefault="1" displayUnit="cm/min">
+              <Parameter id="c5dwPtFs70mbr9xpBMauoQ" name="P (interstitial-&gt;intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" isDefault="1" displayUnit="cm/min">
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="78" />
               </Parameter>
-              <Parameter id="GN-DCZrYME6v9JYbwqK6ig" name="P (intracellular-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" isDefault="1" displayUnit="cm/min">
+              <Parameter id="VkU55G0urkWT1YDMQDJWcg" name="P (intracellular-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" isDefault="1" displayUnit="cm/min">
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="76" />
               </Parameter>
-              <Parameter id="xMLF2zVRuk-OqQKHJwGeBQ" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
+              <Parameter id="mW1EHRW97kCp_-ZV3H5zhw" name="P*SA interstitial -&gt; intracellular" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" isDefault="1" displayUnit="l/min">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="QQSDkmFmcUuioyEv-L0eUA" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="LwFwZC9yzEK_wX8YGGLbbw" name="P*SA interstitial -&gt; intracellular" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" isDefault="1" displayUnit="l/min">
+              <Parameter id="WAcPBhaz00CJdSrPtm-i7w" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="04zHEV9Whku1NIAE0mt3ag" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
+              <Parameter id="h1dVzX_72UK56gIzat2-zw" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="wlWKymOzwkmfZQutWdJybg" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
+              <Parameter id="NnZWEjpC80SDZM6wl-eNBw" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="69" />
               </Parameter>
-              <Parameter id="qgyZIK6EcEeuIocdom4F7A" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
+              <Parameter id="7c2ex0owe0ma67AKo8S0VA" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
               </Parameter>
             </Children>
           </Container>
-          <Parameter id="l0TQJYj9HUygjGKGSPo75w" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_sto" isDefault="1" displayUnit="cm²">
+          <Parameter id="8BxZHw4XQEqBAtB5vdYRMg" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_sto" isDefault="1" displayUnit="cm²">
             <Tags>
               <Tag value="Neighborhood: Interstitial / Intracellular" />
             </Tags>
@@ -15102,167 +15183,326 @@
           </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="jkAjYhd51kGSoJHviwWyTQ" name="Stomach_bc_PortalVein_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="bVcnFvYznkamCQ0CvBK-xw" secondNeighbor="-ce4W1W9u0-sDuce1ufJ_A">
+      <NeighborhoodBuilder id="LobG2L3i5keNeHk37MbNhg" name="Stomach_pls_PortalVein_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="zuvUyT7oak2Zhtu8j2cZMg" secondNeighbor="vihskj6fJkaqqVik0r1DIg">
         <Tags>
-          <Tag value="Neighborhood: BloodCells / BloodCells" />
+          <Tag value="Neighborhood: Plasma / Plasma" />
+        </Tags>
+        <Children>
+          <Container id="I8lj0CZt2UyxsZBmhj0OIw" name="MoleculeProperties" mode="Logical" containerType="Other" />
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="5sOR_XQbd0qjrUjmASsagA" name="Stomach_pls_Stomach_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="zuvUyT7oak2Zhtu8j2cZMg" secondNeighbor="AVrkjZHVYE2BekZ0hnC4Wg">
+        <Tags>
+          <Tag value="Neighborhood: Plasma / BloodCells" />
+        </Tags>
+        <Children>
+          <Container id="Tu7IP-faLE-_55HRGp4GLg" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Parameter id="iBWQxc1gH062M0h-67kJEQ" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" isDefault="1" displayUnit="cm²">
+            <Tags>
+              <Tag value="Neighborhood: Plasma / BloodCells" />
+            </Tags>
+            <Info min="0" flag="122" seq="20" ref="0" bb="32" group="104" />
+          </Parameter>
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="vdN485dgQ0yd_Yqu-IHizQ" name="Stomach_pls_Stomach_int" mode="Logical" containerType="Neighborhood" firstNeighbor="zuvUyT7oak2Zhtu8j2cZMg" secondNeighbor="_GvqcoaP4k2UJRR2NiaDGg">
+        <Tags>
+          <Tag value="Neighborhood: Plasma / Interstitial" />
+        </Tags>
+        <Children>
+          <Container id="h-tf2nNxvUuhv1M8QUQlDA" name="MoleculeProperties" mode="Logical" containerType="Other">
+            <Children>
+              <Parameter id="4I1UahJyvU-JyfkpsTQslA" name="P (plasma&lt;-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
+                <ValueOrigin id="49" source="Other" method="Assumption" description="Assumption: very fast exchange" />
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="77" />
+              </Parameter>
+              <Parameter id="C91HxpLkuESYm5-BaOHX2w" name="Partition coefficient (interstitial/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" isDefault="1">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="70" />
+              </Parameter>
+            </Children>
+          </Container>
+          <Parameter id="P_L_XmJkfkSmtYk-BmQAMw" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" isDefault="1" displayUnit="cm²">
+            <Tags>
+              <Tag value="Neighborhood: Plasma / Interstitial" />
+            </Tags>
+            <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+            <Info min="0" flag="122" seq="17" ref="0" bb="32" group="106" />
+          </Parameter>
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="Q7nHOOLvvEy3lfQhxg9wGQ" name="Lumen_uil_UpperIleum_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="sCpNhHJQCEWV2oakLgPUew" secondNeighbor="ZzglrFxN2USNK0EBKHAKHw">
+        <Tags>
+          <Tag value="Neighborhood: UpperIleum / Plasma" />
         </Tags>
         <Children>
-          <Container id="vz_W5G1HiUK7Ti8pEZ_txg" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="MliyIxd420OImgNwdENhiA" name="MoleculeProperties" mode="Logical" containerType="Other">
+            <Children>
+              <Parameter id="pIv9zEXI4kyRTnKNLF5BZQ" name="Drug absorption rate (lumen to mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_DrugAbsorption_para" isDefault="1" displayUnit="µmol/min">
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+              </Parameter>
+              <Parameter id="1nzejDY74UOo42YTDhNuqQ" name="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" isDefault="1" displayUnit="µmol/min">
+                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
+              <Parameter id="32Yx3WSrCEG6griqyEPhag" name="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" isDefault="1" displayUnit="µmol/min">
+                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
+            </Children>
+          </Container>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="Db8Zr96a20aqOi29fN2eFA" name="Lumen_uil_UpperIleum_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="ESTEWsLHx0OLfQr-M3hs1A" secondNeighbor="nQCFgAfCi0WyyeCINOyruw">
+      <NeighborhoodBuilder id="zi2_hVIyY0WUtCSSpNqFWQ" name="Lumen_uil_UpperIleum_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="sCpNhHJQCEWV2oakLgPUew" secondNeighbor="shLM7VZLMEWIWyy3ZU-Wlw">
         <Tags>
           <Tag value="Neighborhood: UpperIleum / Intracellular" />
         </Tags>
         <Children>
-          <Container id="ckZ_47W_006zVY7G4-v05w" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="oUdrO4T92ke1XFahbEvzmQ" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="jNOlh203ekueXBH7uDhjXw" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K5" isDefault="1">
-                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              <Parameter id="ilbCl5jDN0OEUVFyWmUAKA" name="Drug absorption rate (lumen to mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_DrugAbsorption_trans" isDefault="1" displayUnit="µmol/min">
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
               </Parameter>
-              <Parameter id="6VMqzrhpGEWn-2LaQDKJJQ" name="pKa_pH_WS_cell_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K6" isDefault="1">
+              <Parameter id="YdsaJ-4Cm0OPo8jVnob-kQ" name="P_int_trans_cell_lum_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_cell_lum_factor" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="CGTYfNw_uEKm5qDQ4tSSlQ" name="pKa_pH_WS_cell_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K7" isDefault="1">
+              <Parameter id="F4ySi7SxAU2nHnPVmVypug" name="P_int_trans_lum_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_lum_cell_factor" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="I6DbPRgCLU6rdOEGDnAPYQ" name="pKa_pH_WS_cell_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K8" isDefault="1">
-                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              <Parameter id="ShN9Uw8mGkqHObkhXpOgig" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_K_cell_pls_UpperIleum" isDefault="1">
+                <Info min="0" flag="36" seq="1" ref="0" bb="2" group="67" />
               </Parameter>
-              <Parameter id="QaRakfpuPEuJkMbbDU9WVQ" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F1" isDefault="1">
-                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              <Parameter id="zLEX-RvShkeBT-1cuo9QGA" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_UpperIleum" isDefault="1">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
               </Parameter>
-              <Parameter id="NfbYvD2_A0S4qpijUlJjgw" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F2" isDefault="1">
+              <Parameter id="aHYhDw_iSEaQvgc1xX3xbQ" name="pKa_pH_WS_cell_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F1" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="D07xMuppHUacjJ0kNbMQaw" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F3" isDefault="1">
+              <Parameter id="UeX5O2gVXU6AuckcWJjX9Q" name="pKa_pH_WS_cell_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F2" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="NdsthuBKEEirmGzKyR3tdg" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K1" isDefault="1">
+              <Parameter id="lX41omXBOEe0HoSqFYo3Rw" name="pKa_pH_WS_cell_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F3" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="dno2NrM1BU-Jj-J5jwvxug" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K2" isDefault="1">
+              <Parameter id="ozLrE60qn0CE165kB4WeGw" name="pKa_pH_WS_cell_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K1" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="q-owl44VxU-GZfV7Z7Qldw" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K4" isDefault="1">
+              <Parameter id="arpLnSzM0U2TMClMwPEOJA" name="pKa_pH_WS_cell_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K2" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="N29T57usHEKm7PbS09HVCA" name="pKa_pH_WS_cell_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K3" isDefault="1">
+              <Parameter id="IxCI3_AKM0mcgR_bOPpNGQ" name="pKa_pH_WS_cell_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K3" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="tp9z871q-kOD_PzUylfj-A" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K6" isDefault="1">
+              <Parameter id="ikTbaUHQIEKR2cyLz8BiJg" name="pKa_pH_WS_cell_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K4" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="wz31geYHO0Cf5RMBlOSRAQ" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K7" isDefault="1">
+              <Parameter id="av1M1g8iykenbIbYCK8sgQ" name="pKa_pH_WS_cell_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K5" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="NYLegS3UdkaMuZp6vn9GUw" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K8" isDefault="1">
+              <Parameter id="aHHVD_NiGUGgl858OSeN7A" name="pKa_pH_WS_cell_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K6" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="FpAW3ZHGfkqM700rhq81MQ" name="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" isDefault="1" displayUnit="µmol/min">
-                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
-              </Parameter>
-              <Parameter id="MjI8d35ezkePSs5u_vjbsQ" name="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" isDefault="1" displayUnit="µmol/min">
-                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
-              </Parameter>
-              <Parameter id="wb3R1slqh0qbI9ClNrSvtg" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K3" isDefault="1">
+              <Parameter id="aSxniWLzdESG6tWQ8Gc8Pg" name="pKa_pH_WS_cell_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K7" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="ISxXciucsEqZHpVoDJ_ZTw" name="P_int_trans_cell_lum_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_cell_lum_factor" isDefault="1">
+              <Parameter id="PjYK8zNagk2BXYt4y_P57w" name="pKa_pH_WS_cell_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K8" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="Lr_jT_pyoESk93EHH8h3og" name="pKa_pH_WS_cell_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K5" isDefault="1">
+              <Parameter id="HzAtBKg63UCxTeB8ReebPQ" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F1" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="6hGbs7eu-keiJXNm7oZjDA" name="Drug absorption rate (lumen to mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_DrugAbsorption_trans" isDefault="1" displayUnit="µmol/min">
-                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+              <Parameter id="84nSHCLTZUKCYNvOQy0hyQ" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F2" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="BUP7Zm9FJUuHR1bs_3ZdnA" name="pKa_pH_WS_cell_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K4" isDefault="1">
+              <Parameter id="DjSGW7w8-kOTOmIGnB0VHQ" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F3" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="wx_EoFrwKUeAfv9e_DHQ_A" name="P_int_trans_lum_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_lum_cell_factor" isDefault="1">
+              <Parameter id="9J6T7OYIOUORO7QZ8UfthQ" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K1" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="Yc1yhwWwXkmoQjJAvq6heQ" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_K_cell_pls_UpperIleum" isDefault="1">
-                <Info min="0" flag="36" seq="1" ref="0" bb="2" group="67" />
+              <Parameter id="K_tRbAYkkUuLVZL35Anpdw" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K2" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="XpVxUO9ev0ShJt1qGcNZBQ" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_UpperIleum" isDefault="1">
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+              <Parameter id="fQ0IY-bM2kit1OgW-29nYA" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K3" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="KUQAS4d_F0OEFPYjG23ceQ" name="pKa_pH_WS_cell_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F1" isDefault="1">
+              <Parameter id="Ih__FDST7k6qNJhT7K5r_A" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K4" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="BcWpS53wWkmyleYAerWhEw" name="pKa_pH_WS_cell_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F2" isDefault="1">
+              <Parameter id="tFo04MOxPE6MU3IrLXly4w" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K5" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="pq9mdWeV60yAK-twxgkADA" name="pKa_pH_WS_cell_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F3" isDefault="1">
+              <Parameter id="OmWQZU04h02tWyhX0CU3-g" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K6" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="pejPStbtMU6dyIjZJ4ngrA" name="pKa_pH_WS_cell_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K1" isDefault="1">
+              <Parameter id="MLn6-ZQCiU2cdoV8PbMmSA" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K7" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="J0L-damIbE6-X2EO2gCUxw" name="pKa_pH_WS_cell_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K2" isDefault="1">
+              <Parameter id="PXxXwiaERE21TBpkAb0vgQ" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K8" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
+              <Parameter id="0d5GAXgGakGwtjA4un7X_A" name="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" isDefault="1" displayUnit="µmol/min">
+                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
+              <Parameter id="Odv7wg4KPkiKcaw14T4Aog" name="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" isDefault="1" displayUnit="µmol/min">
+                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
             </Children>
           </Container>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="oZGDVKUSjkSr7JQwSHIo7g" name="Stomach_pls_PortalVein_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="w7fjJlr-C0KeticP__wcVg" secondNeighbor="meWL4gPZR0uFouhVl8UsOw">
+      <NeighborhoodBuilder id="mOCLaowuzEOA3Vdxh8ELHw" name="UpperIleum_pls_PortalVein_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="ZzglrFxN2USNK0EBKHAKHw" secondNeighbor="vihskj6fJkaqqVik0r1DIg">
         <Tags>
           <Tag value="Neighborhood: Plasma / Plasma" />
         </Tags>
         <Children>
-          <Container id="57tmUbjmd0uFIo-afPqEwg" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="Wid6WhkwGEehC1K6XKhEwg" name="MoleculeProperties" mode="Logical" containerType="Other">
+            <Children>
+              <Parameter id="zuJjrm3IWk-xpJKdxZVLqA" name="Mass transfer rate (mucosa to portal vein plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPvePlasma" isDefault="1" displayUnit="µmol/min">
+                <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+              </Parameter>
+            </Children>
+          </Container>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="qrBdsW5jSkKFRsxzhGjqEw" name="Stomach_pls_Stomach_int" mode="Logical" containerType="Neighborhood" firstNeighbor="w7fjJlr-C0KeticP__wcVg" secondNeighbor="QmDulSYPKUeL8N3K5vwsYQ">
+      <NeighborhoodBuilder id="ZPeCfJ15H0ixknYQE5pXEQ" name="UpperIleum_bc_PortalVein_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="A-W-9HQaxU2NdeD01TJ9vw" secondNeighbor="eN7tQLMOREG3-_sYJSczng">
         <Tags>
-          <Tag value="Neighborhood: Plasma / Interstitial" />
+          <Tag value="Neighborhood: BloodCells / BloodCells" />
         </Tags>
         <Children>
-          <Container id="dlhNzERb50W3zgVgO1v1sg" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="5t-A8kVfVkuBHCEEcmPl3A" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="F2sltGuC0EePzIaVvia4_g" name="P (plasma&lt;-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
-                <ValueOrigin id="49" method="Assumption" description="TODO: Default: very fast exchange" />
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="77" />
+              <Parameter id="EET5A8QeXkevhoBNxfLKWQ" name="Mass transfer rate (mucosa to portal vein blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPveBloodCells" isDefault="1" displayUnit="µmol/min">
+                <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
               </Parameter>
-              <Parameter id="4QcXccI-PUmH4-7F20PPXA" name="Partition coefficient (interstitial/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" isDefault="1">
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="70" />
+            </Children>
+          </Container>
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="ml6TZBuNyk-7knUtzZIG6w" name="SmallIntestine_bc_PortalVein_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="dh_9PrSgd0KpJxAtQiKHRw" secondNeighbor="eN7tQLMOREG3-_sYJSczng">
+        <Tags>
+          <Tag value="Neighborhood: BloodCells / BloodCells" />
+        </Tags>
+        <Children>
+          <Container id="sRm4I-b5a0mKMz4DT9Dx_A" name="MoleculeProperties" mode="Logical" containerType="Other" />
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="t2IxpEbj70itKnoxb3gpUA" name="SmallIntestine_int_SmallIntestine_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="0jJslYrVHUKN8OMs3US0yQ" secondNeighbor="1pSz8VtjLEut64GUYnknDg">
+        <Tags>
+          <Tag value="Neighborhood: Interstitial / Intracellular" />
+          <Tag value="Small intestine  neighborhood" />
+        </Tags>
+        <Children>
+          <Container id="5zJpV0TkYUyDzLnAjDrGwA" name="MoleculeProperties" mode="Logical" containerType="Other">
+            <Children>
+              <Parameter id="Zrb1E9H2rUyXFUe-50sl4A" name="P (interstitial-&gt;intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" isDefault="1" displayUnit="cm/min">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="78" />
+              </Parameter>
+              <Parameter id="FH2iaxjfhEivQinKhPUCAg" name="P (intracellular-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" isDefault="1" displayUnit="cm/min">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="76" />
+              </Parameter>
+              <Parameter id="EkeUNyTP0Um9tmgwVGU7Yg" name="P*SA interstitial -&gt; intracellular" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" isDefault="1" displayUnit="l/min">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="0IINQ0vIa0iwViEYFwAGHg" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="3BwDBbcWSEaWAYvLl5cXmg" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="2qEnDPHUjkaIplrPnUCg4Q" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="QRE1V2XxNk2Nt6vPN_uhhg" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="69" />
+              </Parameter>
+              <Parameter id="dZyvgHI4RUyfpsd0eBAg6A" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
               </Parameter>
             </Children>
           </Container>
-          <Parameter id="0gu3Ins2M0W4erU6mgL01w" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" isDefault="1" displayUnit="cm²">
+          <Parameter id="EXnFiZwY1UK3au4Pxjl4SA" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_sin" isDefault="1" displayUnit="cm²">
             <Tags>
-              <Tag value="Neighborhood: Plasma / Interstitial" />
+              <Tag value="Neighborhood: Interstitial / Intracellular" />
+              <Tag value="Small intestine  neighborhood" />
             </Tags>
-            <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-            <Info min="0" flag="122" seq="17" ref="0" bb="32" group="106" />
+            <Info min="0" flag="122" seq="15" ref="0" bb="32" group="105" />
           </Parameter>
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       </NeighborhoodBuilder>
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+      <NeighborhoodBuilder id="MiBX7yLIJUaeFhlQ8OKRpA" name="SmallIntestine_pls_PortalVein_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="Vxis-jG0SEele2dNhDDVJg" secondNeighbor="vihskj6fJkaqqVik0r1DIg">
+        <Tags>
+          <Tag value="Neighborhood: Plasma / Plasma" />
+        </Tags>
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+          <Container id="OhkvboW_uU-Mv-8TIeeTpQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
+        </Children>
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+      <NeighborhoodBuilder id="1cOefeqAN0yjecoYWuoL0g" name="SmallIntestine_pls_SmallIntestine_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="Vxis-jG0SEele2dNhDDVJg" secondNeighbor="dh_9PrSgd0KpJxAtQiKHRw">
         <Tags>
           <Tag value="Neighborhood: Plasma / BloodCells" />
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         </Tags>
         <Children>
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+          <Container id="RtezeRLkokC4lGF6YEeB0Q" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Parameter id="XdDmsVZqDUGqlS5DrhU9qQ" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls_sinlin" isDefault="1" displayUnit="cm²">
             <Tags>
               <Tag value="Neighborhood: Plasma / BloodCells" />
+              <Tag value="Small intestine  neighborhood" />
             </Tags>
-            <Info min="0" flag="122" seq="20" ref="0" bb="32" group="104" />
+            <Info min="0" flag="122" seq="18" ref="0" bb="32" group="104" />
+          </Parameter>
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="6s_w2BVpTEysYPsyCaQ1oQ" name="SmallIntestine_pls_SmallIntestine_int" mode="Logical" containerType="Neighborhood" firstNeighbor="Vxis-jG0SEele2dNhDDVJg" secondNeighbor="0jJslYrVHUKN8OMs3US0yQ">
+        <Tags>
+          <Tag value="Neighborhood: Plasma / Interstitial" />
+          <Tag value="Small intestine  neighborhood" />
+        </Tags>
+        <Children>
+          <Container id="mv4GSmNKw0m_1oLGc6Zo3w" name="MoleculeProperties" mode="Logical" containerType="Other">
+            <Children>
+              <Parameter id="Pg6xEWTNdEC4_gfSf1XG7Q" name="P (plasma&lt;-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
+                <ValueOrigin id="49" source="Other" method="Assumption" description="Assumption: very fast exchange" />
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="77" />
+              </Parameter>
+              <Parameter id="Pf6vsJzaIE--iAR2MOD0vg" name="Partition coefficient (interstitial/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" isDefault="1">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="70" />
+              </Parameter>
+            </Children>
+          </Container>
+          <Parameter id="lzKSuRl56UC3NRXGn2zmrA" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int_sinlin" isDefault="1" displayUnit="cm²">
+            <Tags>
+              <Tag value="Neighborhood: Plasma / Interstitial" />
+              <Tag value="Small intestine  neighborhood" />
+            </Tags>
+            <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
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+      <NeighborhoodBuilder id="D95PV0TbQka5Ij1HYEXZeA" name="SmallIntestine_pls_Duodenum_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="Vxis-jG0SEele2dNhDDVJg" secondNeighbor="C-d2PMLTSE2CX0a7o185GA">
+        <Tags>
+          <Tag value="Neighborhood: Plasma / Plasma" />
+        </Tags>
+        <Children>
+          <Container id="-xAHZnIkFEiGC7XHoeQIYw" name="MoleculeProperties" mode="Logical" containerType="Other">
+            <Children>
+              <Parameter id="MrxUoYRzek-0KjT6013VOQ" name="Mass transfer rate (intestine to mucosa plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaPlasma" isDefault="1" displayUnit="µmol/min">
+                <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+              </Parameter>
+            </Children>
+          </Container>
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="4TyhccvO4EG-u3yPxAcjiQ" name="SmallIntestine_bc_Duodenum_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="dh_9PrSgd0KpJxAtQiKHRw" secondNeighbor="nwFYd1vNG0uI8cY3lrK-Zw">
         <Tags>
           <Tag value="Neighborhood: BloodCells / BloodCells" />
         </Tags>
         <Children>
-          <Container id="XFN0fzbghk-WcdotTy2AcQ" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="shQwLiI45UqMnASujAvKxg" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="5SG18ZCfYUKA1k-Fj3By0w" name="Mass transfer rate (mucosa to portal vein blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPveBloodCells" isDefault="1" displayUnit="µmol/min">
+              <Parameter id="qtBGo14aJ0W74W81tXNnXA" name="Mass transfer rate (intestine to mucosa blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaBloodCells" isDefault="1" displayUnit="µmol/min">
                 <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
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@@ -15270,14 +15510,14 @@
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+      <NeighborhoodBuilder id="2hSaO5aXcEmTCA82dks5tw" name="SmallIntestine_pls_UpperJejunum_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="Vxis-jG0SEele2dNhDDVJg" secondNeighbor="4CbOfy3paECKcKT3NoWL2w">
         <Tags>
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         </Tags>
         <Children>
-          <Container id="JDrLtj9eYEicv3Qj6o1c-A" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="9s1D-Nd3Qkyb1NRfdSXZXw" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="JjoV3fKiKUGpmV2I_XCBDA" name="Mass transfer rate (mucosa to portal vein plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPvePlasma" isDefault="1" displayUnit="µmol/min">
+              <Parameter id="dxoVsaz8kEyCC2pJMIj-6Q" name="Mass transfer rate (intestine to mucosa plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaPlasma" isDefault="1" displayUnit="µmol/min">
                 <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
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               </Parameter>
@@ -15285,34 +15525,74 @@
           </Container>
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-      <NeighborhoodBuilder id="Uwqz4ZPnBUuGFTz94M3_ng" name="Lumen_uil_UpperIleum_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="ESTEWsLHx0OLfQr-M3hs1A" secondNeighbor="8Ac8jM2ASUOjvqHKHA7z0Q">
+      <NeighborhoodBuilder id="SDKjUOg7ZkaQ6JRbMIQb0Q" name="SmallIntestine_bc_UpperJejunum_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="dh_9PrSgd0KpJxAtQiKHRw" secondNeighbor="2tcy-Ya4DkapvK5NMu6LXQ">
         <Tags>
-          <Tag value="Neighborhood: UpperIleum / Plasma" />
+          <Tag value="Neighborhood: BloodCells / BloodCells" />
         </Tags>
         <Children>
-          <Container id="5WuszlBEg02DkkieeZMaJw" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="3Yfy0Qx7S0S2IyDHU0uEaQ" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="_kl2IACTfEOijPQjunRBmQ" name="Drug absorption rate (lumen to mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_DrugAbsorption_para" isDefault="1" displayUnit="µmol/min">
+              <Parameter id="kW8_EvBWkUSJVQ5LHLWNig" name="Mass transfer rate (intestine to mucosa blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaBloodCells" isDefault="1" displayUnit="µmol/min">
+                <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                 <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
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-                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+            </Children>
+          </Container>
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="knVwyQ6gNkumo1VvSwEc_Q" name="SmallIntestine_pls_LowerJejunum_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="Vxis-jG0SEele2dNhDDVJg" secondNeighbor="_vxo4wcBG0Spf1REJOKECA">
+        <Tags>
+          <Tag value="Neighborhood: Plasma / Plasma" />
+        </Tags>
+        <Children>
+          <Container id="uxsrfK03e0uibiqUhbsldw" name="MoleculeProperties" mode="Logical" containerType="Other">
+            <Children>
+              <Parameter id="G7S1rQoPQE-LtZLw9_6UFw" name="Mass transfer rate (intestine to mucosa plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaPlasma" isDefault="1" displayUnit="µmol/min">
+                <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
               </Parameter>
-              <Parameter id="LIdZogEXE0e17OBsWvfafQ" name="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" isDefault="1" displayUnit="µmol/min">
-                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+            </Children>
+          </Container>
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="yO2sKsoY90iyh2AZhiBJ3A" name="SmallIntestine_bc_LowerJejunum_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="dh_9PrSgd0KpJxAtQiKHRw" secondNeighbor="K659GHjLpkKqC6Y--ONvog">
+        <Tags>
+          <Tag value="Neighborhood: BloodCells / BloodCells" />
+        </Tags>
+        <Children>
+          <Container id="PyBqdyVgzEe0_odAo28CMw" name="MoleculeProperties" mode="Logical" containerType="Other">
+            <Children>
+              <Parameter id="io4RK7ww0Uuk1utj91pA1A" name="Mass transfer rate (intestine to mucosa blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaBloodCells" isDefault="1" displayUnit="µmol/min">
+                <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
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-      <NeighborhoodBuilder id="Yu7BwBiWxkKifhQ8Eg7rhA" name="SmallIntestine_pls_LowerIleum_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="YZG2svoXwkCXDQCWhthiGQ" secondNeighbor="E7GcOFYu-UOF39Lu9dz1iw">
+      <NeighborhoodBuilder id="u1qIN2_0f0-DnyM_r9hWSg" name="SmallIntestine_pls_UpperIleum_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="Vxis-jG0SEele2dNhDDVJg" secondNeighbor="ZzglrFxN2USNK0EBKHAKHw">
         <Tags>
           <Tag value="Neighborhood: Plasma / Plasma" />
         </Tags>
         <Children>
-          <Container id="DW08RtHkakel4qACiDQ2tA" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="HhDTtd5e2Uq6zKdL5H8rsw" name="MoleculeProperties" mode="Logical" containerType="Other">
+            <Children>
+              <Parameter id="puuDoy27gk2T7b3cWb3yFg" name="Mass transfer rate (intestine to mucosa plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaPlasma" isDefault="1" displayUnit="µmol/min">
+                <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+              </Parameter>
+            </Children>
+          </Container>
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="L3JGoCyJAE2k9hJL_PpXQg" name="SmallIntestine_bc_UpperIleum_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="dh_9PrSgd0KpJxAtQiKHRw" secondNeighbor="A-W-9HQaxU2NdeD01TJ9vw">
+        <Tags>
+          <Tag value="Neighborhood: BloodCells / BloodCells" />
+        </Tags>
+        <Children>
+          <Container id="Xg8FAy7AMUqAH0CXQDCJ1g" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="9pDsGkwDgUuYDoBAb1vVyA" name="Mass transfer rate (intestine to mucosa plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaPlasma" isDefault="1" displayUnit="µmol/min">
+              <Parameter id="aKT2aVdY1EeeA6UsNzqqBQ" name="Mass transfer rate (intestine to mucosa blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaBloodCells" isDefault="1" displayUnit="µmol/min">
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                 <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
               </Parameter>
@@ -15320,222 +15600,132 @@
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-      <NeighborhoodBuilder id="QOtsZ21k4Uyfts97TY4AKg" name="Lumen_lil_LowerIleum_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="Lb1SPQ-6FkGtMC4KAGRoSA" secondNeighbor="E7GcOFYu-UOF39Lu9dz1iw">
+      <NeighborhoodBuilder id="3SsAXMikT02T_3lg2K96pQ" name="Lumen_lil_LowerIleum_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="WhhY_lqxWkWM0OtpLodvWw" secondNeighbor="zc7BjQ5jIkCNKX-V89xf8w">
         <Tags>
           <Tag value="Neighborhood: LowerIleum / Plasma" />
         </Tags>
         <Children>
-          <Container id="4ywJtGOT8UqTSEk8dXVbyQ" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="Gni6hEiQB0KUiNfDkGGWcA" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="YIwgJ7-AFkipDO9CY5Q1JA" name="Drug absorption rate (lumen to mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_DrugAbsorption_para" isDefault="1" displayUnit="µmol/min">
+              <Parameter id="d-qS-5l98UCu2n-x_lJyAA" name="Drug absorption rate (lumen to mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_DrugAbsorption_para" isDefault="1" displayUnit="µmol/min">
                 <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
               </Parameter>
-              <Parameter id="Dc7b7v47EkmdOEFUIxJ-5A" name="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" isDefault="1" displayUnit="µmol/min">
+              <Parameter id="PwXEbAgDzUS298PtZ34qUQ" name="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" isDefault="1" displayUnit="µmol/min">
                 <Info flag="52" seq="1" ref="0" bb="2" group="117" />
               </Parameter>
-              <Parameter id="dzNzMA2DWUi8sUyO0M4X4Q" name="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" isDefault="1" displayUnit="µmol/min">
+              <Parameter id="EXerKt-ZRkuVGcQ8Rr1Tow" name="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" isDefault="1" displayUnit="µmol/min">
                 <Info flag="52" seq="1" ref="0" bb="2" group="117" />
               </Parameter>
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-      <NeighborhoodBuilder id="3pSMBWHMsE-H2HpKWWphrg" name="Lumen_lil_LowerIleum_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="Lb1SPQ-6FkGtMC4KAGRoSA" secondNeighbor="4DN3tqIxrEi2lucD2dTPCg">
+      <NeighborhoodBuilder id="lnXBqJSHD0uwJm1gcmorpA" name="Lumen_lil_LowerIleum_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="WhhY_lqxWkWM0OtpLodvWw" secondNeighbor="jIkP3QhTpkaaJF858jl37g">
         <Tags>
           <Tag value="Neighborhood: LowerIleum / Intracellular" />
         </Tags>
         <Children>
-          <Container id="7LdS2NXMEUuSiiWN-6W1ng" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="mfRMJlc5IEKSNqr5X4Mpcw" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="jZGImxaJeUO-209_WQXjKQ" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K3" isDefault="1">
+              <Parameter id="4F-rvzJo8Um36Y6205bRAA" name="Drug absorption rate (lumen to mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_DrugAbsorption_trans" isDefault="1" displayUnit="µmol/min">
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+              </Parameter>
+              <Parameter id="B6syqkCf5ka1A0rpSfq5Lw" name="P_int_trans_cell_lum_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_cell_lum_factor" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="nAB8kXyMhU-9na2PvPVCyw" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K4" isDefault="1">
+              <Parameter id="FYbas9MIwEuZLG6Hy4sTfA" name="P_int_trans_lum_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_lum_cell_factor" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="tzSLi_CbIUuMsaVOpsGWwg" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K5" isDefault="1">
+              <Parameter id="91BxEd-ZQ0uqmtEZEBfvdg" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_K_cell_pls_LowerIleum" isDefault="1">
+                <Info min="0" flag="36" seq="1" ref="0" bb="2" group="67" />
+              </Parameter>
+              <Parameter id="7QlCpzIlHkOVxblKXRA3-w" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_LowerIleum" isDefault="1">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+              </Parameter>
+              <Parameter id="2H6Ca6MIBkaPVTROZOdmrA" name="pKa_pH_WS_cell_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F1" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="OQe3ylrgAEaMjV9nrSEKJg" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K6" isDefault="1">
+              <Parameter id="gfjGQ_RSm0SLm677AMEtgw" name="pKa_pH_WS_cell_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F2" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="mh6qOVn4UEGylo41haNVIw" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K7" isDefault="1">
+              <Parameter id="4N-teuyKy0a5VSyntHeMrQ" name="pKa_pH_WS_cell_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F3" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="jACGVUgpn0CVTseX0TozzQ" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K8" isDefault="1">
+              <Parameter id="vljl6Mr1NEmq422_evio3g" name="pKa_pH_WS_cell_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K1" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="IbwOIvZF6UCGOCyI6PrfOQ" name="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" isDefault="1" displayUnit="µmol/min">
-                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+              <Parameter id="IrnLC2B1ikm-69PvlilEAg" name="pKa_pH_WS_cell_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K2" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="ZYaVuAj_qEyHLTVwS2xkeg" name="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" isDefault="1" displayUnit="µmol/min">
-                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+              <Parameter id="bAwHmCdf5E2VMZf8cSyvNg" name="pKa_pH_WS_cell_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K3" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="4HwhK_ngVEGyAJ9Nhwhfxg" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F3" isDefault="1">
+              <Parameter id="KfC_bu0qSkqCfEYyGXXGsQ" name="pKa_pH_WS_cell_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K4" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="U4sy3F3o_0KXVtShNOYcFg" name="pKa_pH_WS_cell_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F3" isDefault="1">
+              <Parameter id="CZWkCRVvQEqBgwfeYYa-nQ" name="pKa_pH_WS_cell_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K5" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="qhew8jzq70y495TLPC5K0Q" name="Drug absorption rate (lumen to mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_DrugAbsorption_trans" isDefault="1" displayUnit="µmol/min">
-                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+              <Parameter id="-AZDVXNgH0eSg5fK3VeXCA" name="pKa_pH_WS_cell_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K6" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="GogO5wx_wE2wJCt45FUC9A" name="P_int_trans_cell_lum_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_cell_lum_factor" isDefault="1">
+              <Parameter id="vgIgu0_mBEiXDx3_20t9nA" name="pKa_pH_WS_cell_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K7" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="zfEngaWvvkinjhblShmHHQ" name="P_int_trans_lum_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_lum_cell_factor" isDefault="1">
+              <Parameter id="RA0U5Llf-UqfqS-DbuwECA" name="pKa_pH_WS_cell_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K8" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="8ooeJiZVOkq02N3QjMCVMQ" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_K_cell_pls_LowerIleum" isDefault="1">
-                <Info min="0" flag="36" seq="1" ref="0" bb="2" group="67" />
+              <Parameter id="vZNbYwHuH0qnm98TzGHwbA" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F1" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="9pVhwv137ku8KrZmWqC2Ww" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_LowerIleum" isDefault="1">
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
-              </Parameter>
-              <Parameter id="Q6AnayzGKkmriKcs4yAODg" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K2" isDefault="1">
-                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
-              </Parameter>
-              <Parameter id="0s4frhET50esiZrw6bf4Gw" name="pKa_pH_WS_cell_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F2" isDefault="1">
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-              </Parameter>
-              <Parameter id="NYTPR7Vr60yC99fUlTW6oQ" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K1" isDefault="1">
-                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
-              </Parameter>
-              <Parameter id="y4Jqw-f9RUyCMKU8hs9OLw" name="pKa_pH_WS_cell_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K1" isDefault="1">
-                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
-              </Parameter>
-              <Parameter id="cNpfn4JGkkOYwHWKAEEM7g" name="pKa_pH_WS_cell_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K2" isDefault="1">
+              <Parameter id="DdWBibNXc06SPAO-TnxKAw" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F2" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="J1EEZv6Ny0a4ojDB2HuXZg" name="pKa_pH_WS_cell_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K3" isDefault="1">
+              <Parameter id="xzJ547GsWUq8wSe6Z27LYA" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F3" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="k5FoGxXfEUaY7E5vrKmd-w" name="pKa_pH_WS_cell_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K4" isDefault="1">
+              <Parameter id="WIO5KgiRpkuzsTFCIK0a6g" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K1" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="wi1xmYY0nECKyYyXeHrDiA" name="pKa_pH_WS_cell_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K5" isDefault="1">
+              <Parameter id="ovgpiElRQkKzV4-m341x4Q" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K2" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="ft0EQ_lxQkergFkpDrFdwg" name="pKa_pH_WS_cell_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K6" isDefault="1">
+              <Parameter id="iijvkJ6WzEeQLobrdrHFfA" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K3" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="dK118YQ-RU--3LEc6quTvA" name="pKa_pH_WS_cell_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K7" isDefault="1">
+              <Parameter id="O6brpLBizEKMOTvMw63PUA" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K4" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="ft0eG3DI_kq2c1IMyIu-mA" name="pKa_pH_WS_cell_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K8" isDefault="1">
+              <Parameter id="1biUdJu2sEqV6ugICjuMHg" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K5" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="XP0NnAug5Ey9_m6OktdVxg" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F1" isDefault="1">
+              <Parameter id="6jK4AdxeLk6xmx4KTgC_8w" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K6" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="xxb--1KktkOIbOQC3SnjzA" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F2" isDefault="1">
+              <Parameter id="zhrC-M8UJ0SNXbC4ACbGmQ" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K7" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="A-fYdGmVI0-sUFjMX1518A" name="pKa_pH_WS_cell_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F1" isDefault="1">
+              <Parameter id="Hggpp532K0WZT60Woe_M5A" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K8" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-            </Children>
-          </Container>
-        </Children>
-      </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="sWELwGAwYUaNLoqWoNJiyw" name="SmallIntestine_bc_UpperIleum_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="vQgDb52aoEiJZGHfzZ8xhA" secondNeighbor="WMcsnhxGN0-dMioJaAzdBw">
-        <Tags>
-          <Tag value="Neighborhood: BloodCells / BloodCells" />
-        </Tags>
-        <Children>
-          <Container id="lsWjqYRKvEy0X3eNjejA6g" name="MoleculeProperties" mode="Logical" containerType="Other">
-            <Children>
-              <Parameter id="qh-JTBsNc0WsQwXeSX2W_Q" name="Mass transfer rate (intestine to mucosa blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaBloodCells" isDefault="1" displayUnit="µmol/min">
-                <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
-                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
-              </Parameter>
-            </Children>
-          </Container>
-        </Children>
-      </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="PHo7bsi470iXhgpaV4ooQw" name="SmallIntestine_bc_LowerIleum_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="vQgDb52aoEiJZGHfzZ8xhA" secondNeighbor="f9sONmhHJ065miNP8o2zyw">
-        <Tags>
-          <Tag value="Neighborhood: BloodCells / BloodCells" />
-        </Tags>
-        <Children>
-          <Container id="LHr32faPZUWwKYAFZ96jNA" name="MoleculeProperties" mode="Logical" containerType="Other">
-            <Children>
-              <Parameter id="ccodpRNCf0yONV9TvQnoCw" name="Mass transfer rate (intestine to mucosa blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaBloodCells" isDefault="1" displayUnit="µmol/min">
-                <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
-                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
-              </Parameter>
-            </Children>
-          </Container>
-        </Children>
-      </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="iT5W4z4KtE61KJTHBnvCtA" name="LowerIleum_pls_PortalVein_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="E7GcOFYu-UOF39Lu9dz1iw" secondNeighbor="meWL4gPZR0uFouhVl8UsOw">
-        <Tags>
-          <Tag value="Neighborhood: Plasma / Plasma" />
-        </Tags>
-        <Children>
-          <Container id="xXeDilj5vUGUjzPfssDz3A" name="MoleculeProperties" mode="Logical" containerType="Other">
-            <Children>
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-                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
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+              <Parameter id="JKxZWW6GjkmSFjpdSguy4w" name="Mass transfer rate (intestine to mucosa plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaPlasma" isDefault="1" displayUnit="µmol/min">
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@@ -15543,14 +15733,14 @@
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+              <Parameter id="xutCZnMTSUWpoh4raGfjuA" name="Mass transfer rate (intestine to mucosa blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaBloodCells" isDefault="1" displayUnit="µmol/min">
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@@ -15558,14 +15748,14 @@
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+              <Parameter id="fiht0J8N40m6-HNw-i97KA" name="Mass transfer rate (mucosa to portal vein plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPvePlasma" isDefault="1" displayUnit="µmol/min">
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@@ -15573,29 +15763,14 @@
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+              <Parameter id="98GG3rAPbUG-sh0qSGaLPQ" name="Mass transfer rate (mucosa to portal vein blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPveBloodCells" isDefault="1" displayUnit="µmol/min">
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@@ -15603,143 +15778,49 @@
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-        <Tags>
-          <Tag value="Neighborhood: Plasma / Interstitial" />
-          <Tag value="Small intestine  neighborhood" />
-        </Tags>
-        <Children>
-          <Container id="5DKGoJLYkEiUYS61LPNlXA" name="MoleculeProperties" mode="Logical" containerType="Other">
-            <Children>
-              <Parameter id="cuQBde3eKU-JVjpNeOen0w" name="P (plasma&lt;-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
-                <ValueOrigin id="49" method="Assumption" description="TODO: Default: very fast exchange" />
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="77" />
-              </Parameter>
-              <Parameter id="NRfx9J0Dpk6NbkLfudmbtw" name="Partition coefficient (interstitial/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" isDefault="1">
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="70" />
-              </Parameter>
-            </Children>
-          </Container>
-          <Parameter id="F246frbXcEmxF69Ej7Iecg" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int_sinlin" isDefault="1" displayUnit="cm²">
-            <Tags>
-              <Tag value="Neighborhood: Plasma / Interstitial" />
-              <Tag value="Small intestine  neighborhood" />
-            </Tags>
-            <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-            <Info min="0" flag="122" seq="15" ref="0" bb="32" group="106" />
-          </Parameter>
-        </Children>
-      </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="wrpf3aWzbEOHOL8HsqKM_g" name="SmallIntestine_pls_PortalVein_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="YZG2svoXwkCXDQCWhthiGQ" secondNeighbor="meWL4gPZR0uFouhVl8UsOw">
-        <Tags>
-          <Tag value="Neighborhood: Plasma / Plasma" />
-        </Tags>
-        <Children>
-          <Container id="TiSzX-_K7keNo5LnGvEC4Q" name="MoleculeProperties" mode="Logical" containerType="Other" />
-        </Children>
-      </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="ZsZqw9OKKEmqulT2q_v-0A" name="LargeIntestine_int_LargeIntestine_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="4vW_TAT-_kCletKNWBeZFA" secondNeighbor="l6UnmWjZT02jCXvDHCj5Ew">
-        <Tags>
-          <Tag value="Large intestine  neighborhood" />
-          <Tag value="Neighborhood: Interstitial / Intracellular" />
-        </Tags>
-        <Children>
-          <Container id="BHni50crXE6B6ZXHL27BOw" name="MoleculeProperties" mode="Logical" containerType="Other">
-            <Children>
-              <Parameter id="wIdWPZc4tk2e6oGpLoYg5w" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
+              <Parameter id="xLNT_Bba8EyLwgENOlGLNA" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="69" />
               </Parameter>
-              <Parameter id="LHtkgyOOiESuyGq3zmXjvQ" name="P (interstitial-&gt;intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" isDefault="1" displayUnit="cm/min">
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="78" />
-              </Parameter>
-              <Parameter id="Q_H-0ORE_UmJ7dCZbkPKkg" name="P (intracellular-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" isDefault="1" displayUnit="cm/min">
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="76" />
-              </Parameter>
-              <Parameter id="moggu2IALkqELKaFck3Slw" name="P*SA interstitial -&gt; intracellular" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" isDefault="1" displayUnit="l/min">
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
-              </Parameter>
-              <Parameter id="-a4enPR46U20x4v5Rw9XKQ" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
-              </Parameter>
-              <Parameter id="W-VNK9NjEEyIKNwOivaq0Q" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
-              </Parameter>
-              <Parameter id="18T0tpDskUWorjm351j1dA" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
+              <Parameter id="rbc3el1Uf0y8wzoRgTRbcw" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
               </Parameter>
-              <Parameter id="tMw5L-SDY06wPcgmwGDplQ" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
-              </Parameter>
             </Children>
           </Container>
-          <Parameter id="wn44jK4rJ0GHBnN86J8JQQ" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_lin" isDefault="1" displayUnit="cm²">
+          <Parameter id="fPfo0OfM3U-bDzj4gtlbIQ" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_lin" isDefault="1" displayUnit="cm²">
             <Tags>
               <Tag value="Large intestine  neighborhood" />
               <Tag value="Neighborhood: Interstitial / Intracellular" />
@@ -15748,22 +15829,14 @@
           </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="P-32OkbLa0mlu9dDxld6kA" name="LargeIntestine_bc_PortalVein_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="ZIdYD6RFG0SOGlr6-yjOwQ" secondNeighbor="-ce4W1W9u0-sDuce1ufJ_A">
-        <Tags>
-          <Tag value="Neighborhood: BloodCells / BloodCells" />
-        </Tags>
-        <Children>
-          <Container id="MVEyupe1C0eEbZtklwOfTw" name="MoleculeProperties" mode="Logical" containerType="Other" />
-        </Children>
-      </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="LdyHcFlxAEy0B45w08Lhrw" name="LargeIntestine_pls_LargeIntestine_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="S4vsJ43EMEq3UIHZ_UQ7RA" secondNeighbor="ZIdYD6RFG0SOGlr6-yjOwQ">
+      <NeighborhoodBuilder id="RVYPWP7n30q1lnQqZaGpvw" name="LargeIntestine_pls_LargeIntestine_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="7jE5JCYYHEOTeB85aoJVHw" secondNeighbor="hh_A67CorUOAhzpqTVLPOg">
         <Tags>
           <Tag value="Large intestine  neighborhood" />
           <Tag value="Neighborhood: Plasma / BloodCells" />
         </Tags>
         <Children>
-          <Container id="we9VMceR8EqgL5ONYm-g-Q" name="MoleculeProperties" mode="Logical" containerType="Other" />
-          <Parameter id="shKuR6jsyEOzGudU6Kx53Q" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls_sinlin" isDefault="1" displayUnit="cm²">
+          <Container id="kHAmKus-EE6K8olVhlxVWw" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Parameter id="oCuy4zH_e0urmuvE1kVq3g" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls_sinlin" isDefault="1" displayUnit="cm²">
             <Tags>
               <Tag value="Large intestine  neighborhood" />
               <Tag value="Neighborhood: Plasma / BloodCells" />
@@ -15772,24 +15845,24 @@
           </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="qz4Nu4xNNkmkVO2kLUEdAQ" name="LargeIntestine_pls_LargeIntestine_int" mode="Logical" containerType="Neighborhood" firstNeighbor="S4vsJ43EMEq3UIHZ_UQ7RA" secondNeighbor="4vW_TAT-_kCletKNWBeZFA">
+      <NeighborhoodBuilder id="RHTOnohsYkmqZ20VeTytBw" name="LargeIntestine_pls_LargeIntestine_int" mode="Logical" containerType="Neighborhood" firstNeighbor="7jE5JCYYHEOTeB85aoJVHw" secondNeighbor="2abQzCuJ-Emr0ewoarnnyQ">
         <Tags>
           <Tag value="Large intestine  neighborhood" />
           <Tag value="Neighborhood: Plasma / Interstitial" />
         </Tags>
         <Children>
-          <Container id="oSiPVcLXG0G5-szvS6B0Zw" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="yRsGt458Qki_985A68KnPw" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="yBa1O1nakE-1g3BTTa_kVQ" name="P (plasma&lt;-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
-                <ValueOrigin id="49" method="Assumption" description="TODO: Default: very fast exchange" />
+              <Parameter id="cRkyksWtGEO9_tDjQba2yg" name="P (plasma&lt;-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
+                <ValueOrigin id="49" source="Other" method="Assumption" description="Assumption: very fast exchange" />
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="77" />
               </Parameter>
-              <Parameter id="bpOlmxXzAEe77r2Xem2zPA" name="Partition coefficient (interstitial/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" isDefault="1">
+              <Parameter id="6cpn_rlal0K2-iU7yIyweA" name="Partition coefficient (interstitial/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" isDefault="1">
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="70" />
               </Parameter>
             </Children>
           </Container>
-          <Parameter id="l8hgiKbphUmYOb_fS7L6Ag" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int_sinlin" isDefault="1" displayUnit="cm²">
+          <Parameter id="99GKt0p4MEaUQwmuS0Gy0w" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int_sinlin" isDefault="1" displayUnit="cm²">
             <Tags>
               <Tag value="Large intestine  neighborhood" />
               <Tag value="Neighborhood: Plasma / Interstitial" />
@@ -15799,22 +15872,22 @@
           </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="jIPgv-mmh0mWsoWlqRNq_A" name="LargeIntestine_pls_PortalVein_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="S4vsJ43EMEq3UIHZ_UQ7RA" secondNeighbor="meWL4gPZR0uFouhVl8UsOw">
+      <NeighborhoodBuilder id="jb448caVvEGMAl3OwbDkFg" name="LargeIntestine_pls_PortalVein_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="7jE5JCYYHEOTeB85aoJVHw" secondNeighbor="vihskj6fJkaqqVik0r1DIg">
         <Tags>
           <Tag value="Neighborhood: Plasma / Plasma" />
         </Tags>
         <Children>
-          <Container id="9gnK_sNZxkuKdGVq7XqP3A" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="wJAMgPPqKEWw5Kf4jI52ZA" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="ykAqc2KBg0CUBDLZS3lFww" name="LargeIntestine_bc_Rectum_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="ZIdYD6RFG0SOGlr6-yjOwQ" secondNeighbor="82qs1z3BHkWv2WUqNvWppA">
+      <NeighborhoodBuilder id="aV5nGWqznE63HaklWV47sg" name="LargeIntestine_pls_Caecum_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="7jE5JCYYHEOTeB85aoJVHw" secondNeighbor="ZxVt3miuQEiGCJszptmYuQ">
         <Tags>
-          <Tag value="Neighborhood: BloodCells / BloodCells" />
+          <Tag value="Neighborhood: Plasma / Plasma" />
         </Tags>
         <Children>
-          <Container id="0Wxg7Z8S_0iiOzhktnDL2w" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="jbq5Fh0tcU2GkYV0urnZjw" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="BlCi7Oc7eESHMSnUWSPRvw" name="Mass transfer rate (intestine to mucosa blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaBloodCells" isDefault="1" displayUnit="µmol/min">
+              <Parameter id="EhkISW4Hv0e_LnA8hvy1yw" name="Mass transfer rate (intestine to mucosa plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaPlasma" isDefault="1" displayUnit="µmol/min">
                 <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                 <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
               </Parameter>
@@ -15822,14 +15895,14 @@
           </Container>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="-JHH74QKPUeacx2c3EwTKQ" name="LargeIntestine_pls_Rectum_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="S4vsJ43EMEq3UIHZ_UQ7RA" secondNeighbor="0Wkjd6C6ok-KS947nfXutA">
+      <NeighborhoodBuilder id="4vZYfmsJYkaFzYu04WHL5g" name="LargeIntestine_bc_Caecum_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="hh_A67CorUOAhzpqTVLPOg" secondNeighbor="NugBHVuOHEervTrkBVs4wg">
         <Tags>
-          <Tag value="Neighborhood: Plasma / Plasma" />
+          <Tag value="Neighborhood: BloodCells / BloodCells" />
         </Tags>
         <Children>
-          <Container id="b6HrQvV5U0CP6La58FF75A" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="uEL_OrIpJEGPWoEwcVSLkQ" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="t-Y31gsQk02OwR68F5GT5A" name="Mass transfer rate (intestine to mucosa plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaPlasma" isDefault="1" displayUnit="µmol/min">
+              <Parameter id="0n1ftnWT-0SDGlMwS74t_A" name="Mass transfer rate (intestine to mucosa blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaBloodCells" isDefault="1" displayUnit="µmol/min">
                 <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                 <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
               </Parameter>
@@ -15837,14 +15910,14 @@
           </Container>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="bMRZgjrqDEWrcM5lpHe-PA" name="LargeIntestine_bc_ColonAscendens_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="ZIdYD6RFG0SOGlr6-yjOwQ" secondNeighbor="9KAYzyIOgUm0aPJQU3yU1A">
+      <NeighborhoodBuilder id="H8iU2Z8uNU69xxpkYQcblw" name="LargeIntestine_pls_ColonAscendens_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="7jE5JCYYHEOTeB85aoJVHw" secondNeighbor="Enan29lQuku7kissDlHImQ">
         <Tags>
-          <Tag value="Neighborhood: BloodCells / BloodCells" />
+          <Tag value="Neighborhood: Plasma / Plasma" />
         </Tags>
         <Children>
-          <Container id="acB7uGcQlEyMWuXd4b83eg" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="pRVnd1U0Yki3JIqbZp-7hg" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="y0VfgtIXx0mF5fM3d5eXkw" name="Mass transfer rate (intestine to mucosa blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaBloodCells" isDefault="1" displayUnit="µmol/min">
+              <Parameter id="xwaBmzwa_Eet7sZGAfg_Yw" name="Mass transfer rate (intestine to mucosa plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaPlasma" isDefault="1" displayUnit="µmol/min">
                 <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                 <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
               </Parameter>
@@ -15852,14 +15925,14 @@
           </Container>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="VbIsLi3X2kS1Vc8tB98MRw" name="LargeIntestine_bc_ColonSigmoid_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="ZIdYD6RFG0SOGlr6-yjOwQ" secondNeighbor="saCFzb5mNkqDgp9lSJDPtQ">
+      <NeighborhoodBuilder id="EmRVLbx82kqbhwXauuNxQg" name="LargeIntestine_bc_ColonAscendens_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="hh_A67CorUOAhzpqTVLPOg" secondNeighbor="Hoo2O0GaRU2870Bnck5hxw">
         <Tags>
           <Tag value="Neighborhood: BloodCells / BloodCells" />
         </Tags>
         <Children>
-          <Container id="5iAWi2IiGkWOL5SM92MHrA" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="D0xaryp3skGrAucqhMEfDA" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="LiCo9fnu9UebPcWR2airrQ" name="Mass transfer rate (intestine to mucosa blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaBloodCells" isDefault="1" displayUnit="µmol/min">
+              <Parameter id="LcxmAFfY2Uyohz9aUqrByg" name="Mass transfer rate (intestine to mucosa blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaBloodCells" isDefault="1" displayUnit="µmol/min">
                 <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                 <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
               </Parameter>
@@ -15867,14 +15940,14 @@
           </Container>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="91FKV14PPkSZIc07Z85xEQ" name="LargeIntestine_pls_ColonSigmoid_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="S4vsJ43EMEq3UIHZ_UQ7RA" secondNeighbor="OvLTrMh7lk6jo7evtaDYJg">
+      <NeighborhoodBuilder id="2rkT0NAV4kmtGwjW-661Cg" name="LargeIntestine_pls_ColonTransversum_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="7jE5JCYYHEOTeB85aoJVHw" secondNeighbor="YYnhx2F-NU2lWPQmgq2Ulg">
         <Tags>
           <Tag value="Neighborhood: Plasma / Plasma" />
         </Tags>
         <Children>
-          <Container id="0X39bzgBcUm8WTiZ75U42A" name="MoleculeProperties" mode="Logical" containerType="Other">
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+          <Container id="wMoPl36bR0eVZxWYo4tyKQ" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="BE9T_cHQN0-dgLV1MS7ImA" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+              <Parameter id="TjP7EpTiikyrRi3sqb6lJQ" name="P (interstitial-&gt;intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" isDefault="1" displayUnit="cm/min">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="78" />
               </Parameter>
-              <Parameter id="avaCPhmwv02Q0pa36Y4ZvQ" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="69" />
+              <Parameter id="lmA_oRlzZUW7lVW4oWGeKQ" name="P (intracellular-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" isDefault="1" displayUnit="cm/min">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="76" />
               </Parameter>
-              <Parameter id="UiaW9pb5gkODqeCN_tEwKA" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
+              <Parameter id="RUkqh94EW06RyWDLtczl-w" name="P*SA interstitial -&gt; intracellular" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" isDefault="1" displayUnit="l/min">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="zQg5Sd0qR0aIq8xe1XN6pQ" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
+              <Parameter id="RRjUGegpQkOIwJe8a3rSlg" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="Jjdw5uGoNkG99oXKJm98Lg" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
+              <Parameter id="sZ1mQaUpnE-nGUgOqmg52g" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="kY6kITTa6UW1xdFmzFbJDA" name="P*SA interstitial -&gt; intracellular" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" isDefault="1" displayUnit="l/min">
+              <Parameter id="9jvg3wVOMEubF_BT_BPCxA" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="AD--JbgsGUyt2zcozHj-sw" name="P (intracellular-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" isDefault="1" displayUnit="cm/min">
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="76" />
+              <Parameter id="kLF_CebgL06X28EDtuk3aA" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="69" />
               </Parameter>
-              <Parameter id="q0ao2-WpZkqlQW4PAY9Cww" name="P (interstitial-&gt;intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" isDefault="1" displayUnit="cm/min">
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="78" />
+              <Parameter id="WPBrqGjoxUe_AaMw7tsYTA" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
               </Parameter>
             </Children>
           </Container>
-          <Parameter id="lFL8RhyDDUyyrwDw1d0-Lg" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_periportal" isDefault="1" displayUnit="cm²">
+          <Parameter id="fr9ePzmd906RoZjuP5fWZA" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_periportal" isDefault="1" displayUnit="cm²">
             <Tags>
               <Tag value="Neighborhood: Interstitial / Intracellular" />
             </Tags>
@@ -16079,13 +16152,13 @@
           </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="Gi0l4CNzV0mrk7Y_QiCw1w" name="Periportal_pls_Periportal_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="n4-XDHcnZ0yxVH6LrkIC0g" secondNeighbor="OOKAJBi8FU6IijIFPRHPcQ">
+      <NeighborhoodBuilder id="fbdhI9e2AUCqJc9Dbd9_Sw" name="Periportal_pls_Periportal_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="bo4cNXLni0i__twz_kf3zw" secondNeighbor="T23Nmml0lkOrwg34wc2z-g">
         <Tags>
           <Tag value="Neighborhood: Plasma / BloodCells" />
         </Tags>
         <Children>
-          <Container id="NFKavFPDG0KMB_Lx8micow" name="MoleculeProperties" mode="Logical" containerType="Other" />
-          <Parameter id="LIeKQtFrdUqNbnWDbxcd5Q" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_pls_bc_periportal" isDefault="1" displayUnit="cm²">
+          <Container id="9vq3FVK2s02y0_Nof2IpOA" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Parameter id="whGaGr9VxkqMLoofC2NeEQ" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_pls_bc_periportal" isDefault="1" displayUnit="cm²">
             <Tags>
               <Tag value="Neighborhood: Plasma / BloodCells" />
             </Tags>
@@ -16093,23 +16166,23 @@
           </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="TYCxTBvDfUWbtJLrCoi-bA" name="Periportal_pls_Periportal_int" mode="Logical" containerType="Neighborhood" firstNeighbor="n4-XDHcnZ0yxVH6LrkIC0g" secondNeighbor="ZgWjKjCZfEaY76X_FhYDXg">
+      <NeighborhoodBuilder id="f1LQgj_aTEahfXh3HT7c6w" name="Periportal_pls_Periportal_int" mode="Logical" containerType="Neighborhood" firstNeighbor="bo4cNXLni0i__twz_kf3zw" secondNeighbor="lY67q6iJEESxJEDVtYq9Cw">
         <Tags>
           <Tag value="Neighborhood: Plasma / Interstitial" />
         </Tags>
         <Children>
-          <Container id="qcLWAZlwWEy01EBlaEfAFA" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="-FloKjaG3kmI7DpUL9aOlg" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="oEQDDbsPSkaNHX-lWy1LJw" name="P (plasma&lt;-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
-                <ValueOrigin id="49" method="Assumption" description="TODO: Default: very fast exchange" />
+              <Parameter id="z7v-uGueUkCkShY2e3lR_A" name="P (plasma&lt;-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
+                <ValueOrigin id="49" source="Other" method="Assumption" description="Assumption: very fast exchange" />
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="77" />
               </Parameter>
-              <Parameter id="d69l0-Tql0qH1cLI4rAq9w" name="Partition coefficient (interstitial/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" isDefault="1">
+              <Parameter id="Oa0cjU_8Mka2JjKDTKrr7g" name="Partition coefficient (interstitial/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" isDefault="1">
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="70" />
               </Parameter>
             </Children>
           </Container>
-          <Parameter id="P-7WBGpvVE2ekQThw_q98g" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int_periportal" isDefault="1" displayUnit="cm²">
+          <Parameter id="gzQlS0WVF0O0EnyTyJ78GQ" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int_periportal" isDefault="1" displayUnit="cm²">
             <Tags>
               <Tag value="Neighborhood: Plasma / Interstitial" />
             </Tags>
@@ -16117,37 +16190,54 @@
           </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="U7I-z74iyEuXGAgP31odtQ" name="Pericentral_pls_Pericentral_int" mode="Logical" containerType="Neighborhood" firstNeighbor="XVqARQRMDECaH3XJRZV4Sg" secondNeighbor="liEs12AWh06kmbhjBeR7lg">
+      <NeighborhoodBuilder id="98kdbicq2kWTM-lW7IJDeA" name="Pericentral_int_Pericentral_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="K1IcAQchgkipK5dg5KDWXg" secondNeighbor="mnTadGjxaEG5njWMX7v14A">
         <Tags>
-          <Tag value="Neighborhood: Plasma / Interstitial" />
+          <Tag value="Neighborhood: Interstitial / Intracellular" />
         </Tags>
         <Children>
-          <Container id="VIo4Q4wAPkiC-FproAh-Ag" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="TQkQ2FmQQUSdOYNYy42l9Q" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="KY990AMPPkypC76lW9zdvQ" name="P (plasma&lt;-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
-                <ValueOrigin id="49" method="Assumption" description="TODO: Default: very fast exchange" />
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="77" />
+              <Parameter id="aqLrZDkHfkW2dOdJR6gYPg" name="P (interstitial-&gt;intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" isDefault="1" displayUnit="cm/min">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="78" />
               </Parameter>
-              <Parameter id="zpPfo0xVYEWny2oDw156AA" name="Partition coefficient (interstitial/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" isDefault="1">
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="70" />
+              <Parameter id="3vjt3uUeKEWbtJsIzs3rBw" name="P (intracellular-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" isDefault="1" displayUnit="cm/min">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="76" />
+              </Parameter>
+              <Parameter id="RAF067g27U63M_nu1Paz3w" name="P*SA interstitial -&gt; intracellular" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" isDefault="1" displayUnit="l/min">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="gwWF-x5TKE2EjH4XqUoEwA" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="7fH2Qzg9a0SLxCYbBiioRQ" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="-N4k0Gqx002xesmmbMqUyA" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="aJ1kSpnBQ0ii5KlxWuSY4Q" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="69" />
+              </Parameter>
+              <Parameter id="zR-Xy6xmKECJR342Z_56Og" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
               </Parameter>
             </Children>
           </Container>
-          <Parameter id="JQoWgYctUkSQGGeq2Fmepw" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int_pericentral" isDefault="1" displayUnit="cm²">
+          <Parameter id="IW5ZeECirUS-qrS1H4VuPQ" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_pericentral" isDefault="1" displayUnit="cm²">
             <Tags>
-              <Tag value="Neighborhood: Plasma / Interstitial" />
+              <Tag value="Neighborhood: Interstitial / Intracellular" />
             </Tags>
-            <Info min="0" flag="62" seq="10" ref="0" bb="32" group="106" />
+            <Info min="0" flag="62" seq="10" ref="0" bb="32" group="105" />
           </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="HXdZbykBdkC6sm7OkXCfVA" name="Pericentral_pls_Pericentral_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="XVqARQRMDECaH3XJRZV4Sg" secondNeighbor="sE94UOAqcEKpa4myEChUXQ">
+      <NeighborhoodBuilder id="KMymd9yuJUejN0_Bv0WgoQ" name="Pericentral_pls_Pericentral_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="_pV4Se-Z9UWuyrB2KgwaBg" secondNeighbor="7e5U6PFOBUiXJLUy75uuuA">
         <Tags>
           <Tag value="Neighborhood: Plasma / BloodCells" />
         </Tags>
         <Children>
-          <Container id="HWtaPioQGE2BYwYHONFTaQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
-          <Parameter id="6m0U-IJlskCHdSLxYhrEOg" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_pls_bc_pericentral" isDefault="1" displayUnit="cm²">
+          <Container id="fV41RgolR0mk1SLeSvl3Vw" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Parameter id="aMObMT8dIkCP5IoChtAcoA" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_pls_bc_pericentral" isDefault="1" displayUnit="cm²">
             <Tags>
               <Tag value="Neighborhood: Plasma / BloodCells" />
             </Tags>
@@ -16155,128 +16245,72 @@
           </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="LncFyWpuTEm15Of3m7-2Vg" name="Pericentral_int_Pericentral_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="liEs12AWh06kmbhjBeR7lg" secondNeighbor="bJp2QRIu_kmSB4k_-yDzPQ">
+      <NeighborhoodBuilder id="prCF-PGQnkC50cDUYPHizQ" name="Pericentral_pls_Pericentral_int" mode="Logical" containerType="Neighborhood" firstNeighbor="_pV4Se-Z9UWuyrB2KgwaBg" secondNeighbor="K1IcAQchgkipK5dg5KDWXg">
         <Tags>
-          <Tag value="Neighborhood: Interstitial / Intracellular" />
+          <Tag value="Neighborhood: Plasma / Interstitial" />
         </Tags>
         <Children>
-          <Container id="P_WJITrmW0ePb06NhWFm2g" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="iiTo9PSop0qCyPCU-Nxnyw" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="bTsbHj3l8kGGmAVO6Gss6Q" name="P (interstitial-&gt;intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" isDefault="1" displayUnit="cm/min">
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="78" />
-              </Parameter>
-              <Parameter id="BmuFSgqofkKOriT7-esS3Q" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
-              </Parameter>
-              <Parameter id="jeD6MpZJPU6OcYhtmpVmGQ" name="P (intracellular-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" isDefault="1" displayUnit="cm/min">
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="76" />
-              </Parameter>
-              <Parameter id="hhXEskHhP0mg7yVL-qcLfA" name="P*SA interstitial -&gt; intracellular" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" isDefault="1" displayUnit="l/min">
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
-              </Parameter>
-              <Parameter id="LQJ-SQ7rmEWMIODXlBf8WQ" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="69" />
-              </Parameter>
-              <Parameter id="jCR1tV3Pn0mA0STGhP9-5A" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
-              </Parameter>
-              <Parameter id="NeQU1cf6p0qdSS0aCW9C0w" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+              <Parameter id="xFTl5QReHka6n0Sd8SCiUw" name="P (plasma&lt;-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
+                <ValueOrigin id="49" source="Other" method="Assumption" description="Assumption: very fast exchange" />
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="77" />
               </Parameter>
-              <Parameter id="lMNO6NQUM0um6SJrXQlZVw" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+              <Parameter id="3xtKpBJcDUOzKi18MDnVGg" name="Partition coefficient (interstitial/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" isDefault="1">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="70" />
               </Parameter>
             </Children>
           </Container>
-          <Parameter id="99B9jNPSlUexsUM7t74X5A" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_pericentral" isDefault="1" displayUnit="cm²">
-            <Tags>
-              <Tag value="Neighborhood: Interstitial / Intracellular" />
-            </Tags>
-            <Info min="0" flag="62" seq="10" ref="0" bb="32" group="105" />
-          </Parameter>
-        </Children>
-      </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="Mo6sZ3tLvkaasJAuhnEWbw" name="Lung_pls_ArterialBlood_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="IpZVdtsSmUWy8BuWB4nu-g" secondNeighbor="bS-sGM903k-X6Tuo2p8Ujw">
-        <Tags>
-          <Tag value="Neighborhood: Plasma / Plasma" />
-        </Tags>
-        <Children>
-          <Container id="0nFVIoOH-E6rTlkDEJ960g" name="MoleculeProperties" mode="Logical" containerType="Other" />
-        </Children>
-      </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="dS-dUBkmtEWHsOyiPjfM1Q" name="Lung_pls_Lung_int" mode="Logical" containerType="Neighborhood" firstNeighbor="IpZVdtsSmUWy8BuWB4nu-g" secondNeighbor="T8kS11TneUyMD8yKa4Wggg">
-        <Tags>
-          <Tag value="Neighborhood: Plasma / Interstitial" />
-        </Tags>
-        <Children>
-          <Container id="B8CqiKkKy0ivzZ-oYeU4oA" name="MoleculeProperties" mode="Logical" containerType="Other">
-            <Children>
-              <Parameter id="dZhMahrxqkiVxejxqtDHbA" name="Partition coefficient (interstitial/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" isDefault="1">
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="70" />
-              </Parameter>
-              <Parameter id="o-rx9iJud0ChlyqP72Lq2w" name="P (plasma&lt;-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
-                <ValueOrigin id="49" method="Assumption" description="TODO: Default: very fast exchange" />
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="77" />
-              </Parameter>
-            </Children>
-          </Container>
-          <Parameter id="dLHmTlYyokmQe72rHwVzyQ" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" isDefault="1" displayUnit="cm²">
+          <Parameter id="UN3IGSa4SUuCY9xFIDTQdA" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int_pericentral" isDefault="1" displayUnit="cm²">
             <Tags>
               <Tag value="Neighborhood: Plasma / Interstitial" />
             </Tags>
-            <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-            <Info min="0" flag="122" seq="11" ref="0" bb="32" group="106" />
+            <Info min="0" flag="62" seq="10" ref="0" bb="32" group="106" />
           </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="A5Sd_BigAkqXG-U31fbUlg" name="Lung_pls_Lung_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="IpZVdtsSmUWy8BuWB4nu-g" secondNeighbor="Uq75Li0e9E-FWhFmlqUbWQ">
+      <NeighborhoodBuilder id="QBXTeEyjoUaUey0jqtw_rw" name="Lung_bc_ArterialBlood_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="RQY1QKppnUKDcK85r9EBbw" secondNeighbor="zmZFE8nEqEm0ej9vgvDMqA">
         <Tags>
-          <Tag value="Neighborhood: Plasma / BloodCells" />
+          <Tag value="Neighborhood: BloodCells / BloodCells" />
         </Tags>
         <Children>
-          <Container id="LavX1B_rLUqkw9Q4b1YsXg" name="MoleculeProperties" mode="Logical" containerType="Other" />
-          <Parameter id="buwDa-qurEqyBCjTbniF8Q" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" isDefault="1" displayUnit="cm²">
-            <Tags>
-              <Tag value="Neighborhood: Plasma / BloodCells" />
-            </Tags>
-            <Info min="0" flag="122" seq="13" ref="0" bb="32" group="104" />
-          </Parameter>
+          <Container id="GnpKxxqHCkOjkpVUsraZJQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="66c7V074x0mJ8wdYjzniOg" name="Lung_int_Lung_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="T8kS11TneUyMD8yKa4Wggg" secondNeighbor="6tQ3Gid3d0K9sD5HFOTSCQ">
+      <NeighborhoodBuilder id="fgJEONr7uUOlb-_t6XQe9A" name="Lung_int_Lung_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="ETTLvMWN20SCaw0SGm1bKg" secondNeighbor="PLDYPc-pA0CXf1lrZtBM0A">
         <Tags>
           <Tag value="Neighborhood: Interstitial / Intracellular" />
         </Tags>
         <Children>
-          <Container id="rh5sv-lwaEG4Ias6xqtPKg" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="3J24yhW9SkydOZ5qgdmwSA" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="RsxF99dW-UW0vddiqydxqA" name="P (interstitial-&gt;intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" isDefault="1" displayUnit="cm/min">
+              <Parameter id="g3PHkhp9VUu8TP4Lsc0P_A" name="P (interstitial-&gt;intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" isDefault="1" displayUnit="cm/min">
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="78" />
               </Parameter>
-              <Parameter id="KUZdtIfHZkCchchPHAFuAg" name="P (intracellular-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" isDefault="1" displayUnit="cm/min">
+              <Parameter id="MywZY5v71kGhBwxugnn86g" name="P (intracellular-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" isDefault="1" displayUnit="cm/min">
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="76" />
               </Parameter>
-              <Parameter id="D-SCeqW9XkyMQwKlszqn6g" name="P*SA interstitial -&gt; intracellular" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" isDefault="1" displayUnit="l/min">
+              <Parameter id="CWo_iPKftE2Z67bCie3HPg" name="P*SA interstitial -&gt; intracellular" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" isDefault="1" displayUnit="l/min">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="nt3sGuq9QE6MTqTh6A0nnQ" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
+              <Parameter id="jecCH2impUiqkVnWc6PrBQ" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="EGXpVaaiGECDiNd7H09PrQ" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
+              <Parameter id="Euxk24q3DkikQCvboGNShQ" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="In9caqqR0Ua4jYnCPRWurw" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
+              <Parameter id="EzeE4bW5bkCBNEQofB55yw" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="ce2raXtwIUOww3j1xHZmdQ" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
+              <Parameter id="LKEEEAJ_Mk-xpCP1S4Xi1g" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="69" />
               </Parameter>
-              <Parameter id="EkzcaHcWhE-ghMcr6N9-jw" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
+              <Parameter id="5Yj6EZjgEkK7Px6jdwRDvQ" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
               </Parameter>
             </Children>
           </Container>
-          <Parameter id="cqFzYkSH90aE-m_hTIvv-g" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_lng" isDefault="1" displayUnit="cm²">
+          <Parameter id="7tzbm_iSaEatcZbfWkRQig" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_lng" isDefault="1" displayUnit="cm²">
             <Tags>
               <Tag value="Neighborhood: Interstitial / Intracellular" />
             </Tags>
@@ -16284,78 +16318,95 @@
           </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="gFqdJ8ansUK-sTyNpnBCTg" name="Lung_bc_ArterialBlood_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="Uq75Li0e9E-FWhFmlqUbWQ" secondNeighbor="qoa86WWLDUurU06K0cENRA">
+      <NeighborhoodBuilder id="3Mss0bxQ2kW6JPlRGKV4rw" name="Lung_pls_ArterialBlood_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="i-uRKnlh-kKlrDY-98yxAg" secondNeighbor="gQ0ACyX0OkaArtZvQ5x4bA">
         <Tags>
-          <Tag value="Neighborhood: BloodCells / BloodCells" />
+          <Tag value="Neighborhood: Plasma / Plasma" />
         </Tags>
         <Children>
-          <Container id="kS7yDlfvv02F6qhHzdKeIA" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="NOopojAGR0S5xN0XWyjEfQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="0U89RVTjJU-CFr4Lz_cBxA" name="Muscle_pls_VenousBlood_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="2LI7MHC5ZUe9U4VNvxVI9w" secondNeighbor="dt7fUpCxbUGcr9pNef8UCA">
+      <NeighborhoodBuilder id="eyKRa24odUaKRiHgOKcG7Q" name="Lung_pls_Lung_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="i-uRKnlh-kKlrDY-98yxAg" secondNeighbor="RQY1QKppnUKDcK85r9EBbw">
         <Tags>
-          <Tag value="Neighborhood: Plasma / Plasma" />
+          <Tag value="Neighborhood: Plasma / BloodCells" />
         </Tags>
         <Children>
-          <Container id="T8wYBR31wkyfTjlgLmbqbQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="bUCUuWEpaUyO2UcMCikf0Q" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Parameter id="D5c5G9V-4kuMXeKpAmU5kw" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" isDefault="1" displayUnit="cm²">
+            <Tags>
+              <Tag value="Neighborhood: Plasma / BloodCells" />
+            </Tags>
+            <Info min="0" flag="122" seq="13" ref="0" bb="32" group="104" />
+          </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="bg_H_h60BE6YpoASbGsNEw" name="Muscle_pls_Muscle_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="2LI7MHC5ZUe9U4VNvxVI9w" secondNeighbor="kSEHk8YXX0q_Bvhjs5u3wQ">
+      <NeighborhoodBuilder id="Oj_E7_nc6EChOWj3l0Im5Q" name="Lung_pls_Lung_int" mode="Logical" containerType="Neighborhood" firstNeighbor="i-uRKnlh-kKlrDY-98yxAg" secondNeighbor="ETTLvMWN20SCaw0SGm1bKg">
         <Tags>
-          <Tag value="Neighborhood: Plasma / BloodCells" />
+          <Tag value="Neighborhood: Plasma / Interstitial" />
         </Tags>
         <Children>
-          <Container id="KzvQzjSYLU-qBpri9Ho2yA" name="MoleculeProperties" mode="Logical" containerType="Other" />
-          <Parameter id="WnMLk3Vnpkuz2fQN8dQXDQ" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" isDefault="1" displayUnit="cm²">
+          <Container id="J2pZSyynGUW9qzotLc11qA" name="MoleculeProperties" mode="Logical" containerType="Other">
+            <Children>
+              <Parameter id="N2AEo5Sd6kuOzwKoh4zdbQ" name="P (plasma&lt;-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
+                <ValueOrigin id="49" source="Other" method="Assumption" description="Assumption: very fast exchange" />
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="77" />
+              </Parameter>
+              <Parameter id="za5zXYxI9EWPjA6sP7ay5w" name="Partition coefficient (interstitial/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" isDefault="1">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="70" />
+              </Parameter>
+            </Children>
+          </Container>
+          <Parameter id="OaaZUNJoI0q-P_36UcW0hQ" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" isDefault="1" displayUnit="cm²">
             <Tags>
-              <Tag value="Neighborhood: Plasma / BloodCells" />
+              <Tag value="Neighborhood: Plasma / Interstitial" />
             </Tags>
-            <Info min="0" flag="122" seq="14" ref="0" bb="32" group="104" />
+            <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+            <Info min="0" flag="122" seq="11" ref="0" bb="32" group="106" />
           </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="R3GO6x2DPUWOdDbuosmlJw" name="Muscle_bc_VenousBlood_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="kSEHk8YXX0q_Bvhjs5u3wQ" secondNeighbor="H3YIKhsT9kW_XjjpUkxqNg">
+      <NeighborhoodBuilder id="kbvdeouO4EuDI4tjt-704A" name="Muscle_bc_VenousBlood_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="1sOBPguOQU2A81RiIwHu2A" secondNeighbor="bHtbzf2QTkS9BPP8ck7mNg">
         <Tags>
           <Tag value="Neighborhood: BloodCells / BloodCells" />
         </Tags>
         <Children>
-          <Container id="OIjSRFNGH0SHfoAYlif9Ow" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="USuYHC9mcEC9ycyQHlpcxQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="6GkLI2M3z0SfZEpUiYpX9Q" name="Muscle_int_Muscle_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="qy-phnBIJUCvFa4JVcEMnA" secondNeighbor="PA-KMkaV8EaZFpDX1F5o3A">
+      <NeighborhoodBuilder id="JH4KlULwREyQZ7yWy214vw" name="Muscle_int_Muscle_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="nxDcbYYHQEaAHwpJ5JI_wQ" secondNeighbor="MqthY_h2P0mzAS45ZQj5Ww">
         <Tags>
           <Tag value="Neighborhood: Interstitial / Intracellular" />
         </Tags>
         <Children>
-          <Container id="bI4DGmoo-UWBtXw_9S26gw" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="X_d9gS_hcUiR8u7yCQuqAw" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="VoEqyA_IP0CrKBQ1v1N4Jg" name="P*SA interstitial -&gt; intracellular" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" isDefault="1" displayUnit="l/min">
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+              <Parameter id="4rkpNWH4NEmTzO9tEaazLQ" name="P (interstitial-&gt;intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" isDefault="1" displayUnit="cm/min">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="78" />
               </Parameter>
-              <Parameter id="QhnWH3mYXEiwMXjYq12Tzw" name="P (intracellular-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" isDefault="1" displayUnit="cm/min">
+              <Parameter id="7spmGpr2nk65D8DFJqCqwA" name="P (intracellular-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" isDefault="1" displayUnit="cm/min">
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="76" />
               </Parameter>
-              <Parameter id="U1_A5Gc1FkWmruoU-5Kw1g" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
+              <Parameter id="cdlDFFn2WEGAeJWem5XBew" name="P*SA interstitial -&gt; intracellular" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" isDefault="1" displayUnit="l/min">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="Vh-6-egSmUavzrWB2VtzWA" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="14WThoMv00CGQ3b83nnGDQ" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
+              <Parameter id="3fOAJh2uN0KoYb6le94E5w" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="4w3zLSSFEk2Gvlix40NR5w" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
+              <Parameter id="L3efSHFYu0iLr0saHtpg8g" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="wl5PSlodIESPZkUtJUcWHw" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
+              <Parameter id="bBsYIWCgnU-IdUwxSBDzKw" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="69" />
               </Parameter>
-              <Parameter id="Ms2PeLvqN0y9QueKW13EQQ" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
+              <Parameter id="xnqg3QomHUu5oXGptJuhpw" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
               </Parameter>
-              <Parameter id="EsAYjplch0S5znN7UwTjig" name="P (interstitial-&gt;intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" isDefault="1" displayUnit="cm/min">
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="78" />
-              </Parameter>
             </Children>
           </Container>
-          <Parameter id="HSAuBvLEx0e-Fevb34mXhg" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mus" isDefault="1" displayUnit="cm²">
+          <Parameter id="EgVKdgzHG0mVP_6G_0dYvw" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mus" isDefault="1" displayUnit="cm²">
             <Tags>
               <Tag value="Neighborhood: Interstitial / Intracellular" />
             </Tags>
@@ -16363,112 +16414,95 @@
           </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="DSnOUqQzQECCKzmtT4QN9A" name="Muscle_pls_Muscle_int" mode="Logical" containerType="Neighborhood" firstNeighbor="2LI7MHC5ZUe9U4VNvxVI9w" secondNeighbor="qy-phnBIJUCvFa4JVcEMnA">
+      <NeighborhoodBuilder id="cNLIgM_SyUiygkJhY1CA6Q" name="Muscle_pls_Muscle_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="__53rbP1vUqN8-pa2a0EGQ" secondNeighbor="1sOBPguOQU2A81RiIwHu2A">
         <Tags>
-          <Tag value="Neighborhood: Plasma / Interstitial" />
+          <Tag value="Neighborhood: Plasma / BloodCells" />
         </Tags>
         <Children>
-          <Container id="SYNRuWSONES4HVzp0rpiIg" name="MoleculeProperties" mode="Logical" containerType="Other">
-            <Children>
-              <Parameter id="ocUJYlJsI0mUN-kYHTCvvg" name="Partition coefficient (interstitial/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" isDefault="1">
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="70" />
-              </Parameter>
-              <Parameter id="OAvgI7VZhUmcTc00ei3Cjw" name="P (plasma&lt;-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
-                <ValueOrigin id="49" method="Assumption" description="TODO: Default: very fast exchange" />
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="77" />
-              </Parameter>
-            </Children>
-          </Container>
-          <Parameter id="ath6GdXCwUa_cuhboqmJdg" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" isDefault="1" displayUnit="cm²">
+          <Container id="ffL6M7x2vkScHrcQNIG8yw" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Parameter id="-1dY0Z8k_0eYwtt1KDC5Xg" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" isDefault="1" displayUnit="cm²">
             <Tags>
-              <Tag value="Neighborhood: Plasma / Interstitial" />
+              <Tag value="Neighborhood: Plasma / BloodCells" />
             </Tags>
-            <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-            <Info min="0" flag="122" seq="12" ref="0" bb="32" group="106" />
+            <Info min="0" flag="122" seq="14" ref="0" bb="32" group="104" />
           </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="S4taRGB84kq1PbTNNlsdOg" name="Pancreas_pls_Pancreas_int" mode="Logical" containerType="Neighborhood" firstNeighbor="4f6Tr0fjFEihF5_rAmMPMw" secondNeighbor="chYfMwpRgk-pf-wI_rCZzw">
+      <NeighborhoodBuilder id="SHtHxPI_XUWkUV9wTllDww" name="Muscle_pls_Muscle_int" mode="Logical" containerType="Neighborhood" firstNeighbor="__53rbP1vUqN8-pa2a0EGQ" secondNeighbor="nxDcbYYHQEaAHwpJ5JI_wQ">
         <Tags>
           <Tag value="Neighborhood: Plasma / Interstitial" />
         </Tags>
         <Children>
-          <Container id="upquy4jyg0CUGZi4eitdog" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="cAckx0cxKEqWC1OUgWf20g" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="Jvycojx2skCjn5HVPJY-vA" name="P (plasma&lt;-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
-                <ValueOrigin id="49" method="Assumption" description="TODO: Default: very fast exchange" />
+              <Parameter id="_VK5gzvaU0ufitnBVw6N9Q" name="P (plasma&lt;-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
+                <ValueOrigin id="49" source="Other" method="Assumption" description="Assumption: very fast exchange" />
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="77" />
               </Parameter>
-              <Parameter id="eDwe0XAzEE2VlZutVlkWWA" name="Partition coefficient (interstitial/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" isDefault="1">
+              <Parameter id="gjdgLOE7uUy-3orl1OUirQ" name="Partition coefficient (interstitial/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" isDefault="1">
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="70" />
               </Parameter>
             </Children>
           </Container>
-          <Parameter id="FtPmNRn9skG8Zopi7mcXWA" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" isDefault="1" displayUnit="cm²">
+          <Parameter id="1qz7F6jVeUGyscZ-UUZymg" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" isDefault="1" displayUnit="cm²">
             <Tags>
               <Tag value="Neighborhood: Plasma / Interstitial" />
             </Tags>
             <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-            <Info min="0" flag="122" seq="13" ref="0" bb="32" group="106" />
+            <Info min="0" flag="122" seq="12" ref="0" bb="32" group="106" />
           </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="LplMLiLLKECTgTNBMA9btw" name="Pancreas_pls_PortalVein_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="4f6Tr0fjFEihF5_rAmMPMw" secondNeighbor="meWL4gPZR0uFouhVl8UsOw">
+      <NeighborhoodBuilder id="ttjGlJ6xxEGXCtmQZR8L0Q" name="Muscle_pls_VenousBlood_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="__53rbP1vUqN8-pa2a0EGQ" secondNeighbor="Ans5EKfuF0W1dnzkXjqTlg">
         <Tags>
           <Tag value="Neighborhood: Plasma / Plasma" />
         </Tags>
         <Children>
-          <Container id="kkgImaA7DEqy_htCzTDJMQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="KuvsZ8LAlkyBg0vm73swqA" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="5FHpeDSQe0iuFMmolEMh2w" name="Pancreas_pls_Pancreas_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="4f6Tr0fjFEihF5_rAmMPMw" secondNeighbor="gEGAVqLWS0a6pHVF1xUItg">
+      <NeighborhoodBuilder id="6RTcMraiRUqqdDvSHRRetg" name="Pancreas_bc_PortalVein_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="ZLa6meN3FU6VPCDK8AuAZQ" secondNeighbor="eN7tQLMOREG3-_sYJSczng">
         <Tags>
-          <Tag value="Neighborhood: Plasma / BloodCells" />
+          <Tag value="Neighborhood: BloodCells / BloodCells" />
         </Tags>
         <Children>
-          <Container id="YHaEc8Sa5kGYRW6aIJqfmw" name="MoleculeProperties" mode="Logical" containerType="Other" />
-          <Parameter id="WTMGIFvMp0uXkYzfHrHDqA" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" isDefault="1" displayUnit="cm²">
-            <Tags>
-              <Tag value="Neighborhood: Plasma / BloodCells" />
-            </Tags>
-            <Info min="0" flag="122" seq="15" ref="0" bb="32" group="104" />
-          </Parameter>
+          <Container id="8KZRv8oGekWVb3Dh4esQEw" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="M6mYpZ7nEUmZDH0EVdqoAg" name="Pancreas_int_Pancreas_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="chYfMwpRgk-pf-wI_rCZzw" secondNeighbor="t_7b7Gkk80iuLwL4YIEeTA">
+      <NeighborhoodBuilder id="Ebg8Xx1j-k6l-eRpSOhF4g" name="Pancreas_int_Pancreas_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="TvORy5iMCky7sH4I0je24w" secondNeighbor="yzltq-2pykeZxS1BI_2tEQ">
         <Tags>
           <Tag value="Neighborhood: Interstitial / Intracellular" />
         </Tags>
         <Children>
-          <Container id="hCSgvlnqzEiizWPdGcPgwA" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="5PXyJS5K8kOa7MSJ4rnlcw" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="YsAh_ek050mTUjQMxOgYng" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
-              </Parameter>
-              <Parameter id="jBTV_nXHaUqtUx069ov0fQ" name="P (interstitial-&gt;intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" isDefault="1" displayUnit="cm/min">
+              <Parameter id="UOpv5HNWCUepWTMepELtWQ" name="P (interstitial-&gt;intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" isDefault="1" displayUnit="cm/min">
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="78" />
               </Parameter>
-              <Parameter id="O5YDgqVPY0aTenPNe8DTLw" name="P (intracellular-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" isDefault="1" displayUnit="cm/min">
+              <Parameter id="dXNMmBFwa0aNeWiTLxK6zA" name="P (intracellular-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" isDefault="1" displayUnit="cm/min">
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="76" />
               </Parameter>
-              <Parameter id="3EMiRxCBH0WhSVF_h9rDPA" name="P*SA interstitial -&gt; intracellular" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" isDefault="1" displayUnit="l/min">
+              <Parameter id="OLdCScVDx0Kuyh9DzMMAjQ" name="P*SA interstitial -&gt; intracellular" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" isDefault="1" displayUnit="l/min">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="TRKtflAGtE2xJ2bANFFhbA" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="LQ23Hdo-nkimqYWHt2Zjaw" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="UtR3IWDjpUi-DcItnXkBrA" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
+              <Parameter id="kAw6MfMCjkCPwGcCjkwF_A" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="FcJ5vSABlEKPqgCc2ghz4w" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
+              <Parameter id="uA1nw6HmZUewmWHQf7iW5Q" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="69" />
               </Parameter>
-              <Parameter id="LqmPH-cNcEm2W0hGo4GioA" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
+              <Parameter id="25SzkTrF30iC8Q3dAnMUSQ" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
               </Parameter>
-              <Parameter id="qzqTAFuEek2K9NMyjbeDnQ" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
-              </Parameter>
             </Children>
           </Container>
-          <Parameter id="u7exr7wNFEi5WjFw2ehRDw" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_pan" isDefault="1" displayUnit="cm²">
+          <Parameter id="2lC2QnbDdUCb8hSYX92z5A" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_pan" isDefault="1" displayUnit="cm²">
             <Tags>
               <Tag value="Neighborhood: Interstitial / Intracellular" />
             </Tags>
@@ -16476,169 +16510,208 @@
           </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="lMJLGqBMNEyMqCjdZVlVfw" name="Pancreas_bc_PortalVein_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="gEGAVqLWS0a6pHVF1xUItg" secondNeighbor="-ce4W1W9u0-sDuce1ufJ_A">
+      <NeighborhoodBuilder id="6YZJxP2ESki0mrsAqVPHxQ" name="Pancreas_pls_Pancreas_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="-nHuc1cRH0moGvDmxl1hTw" secondNeighbor="ZLa6meN3FU6VPCDK8AuAZQ">
         <Tags>
-          <Tag value="Neighborhood: BloodCells / BloodCells" />
+          <Tag value="Neighborhood: Plasma / BloodCells" />
         </Tags>
         <Children>
-          <Container id="wvpUokrtPkGdKEEfxkXqkw" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="26uAfb0CwUCNrLoHCRFyvA" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Parameter id="zq03s8n3pk-NOy48r0dODQ" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" isDefault="1" displayUnit="cm²">
+            <Tags>
+              <Tag value="Neighborhood: Plasma / BloodCells" />
+            </Tags>
+            <Info min="0" flag="122" seq="15" ref="0" bb="32" group="104" />
+          </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="JNejdO4OYkWa_k2j8MUEcw" name="Rectum_pls_PortalVein_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="0Wkjd6C6ok-KS947nfXutA" secondNeighbor="meWL4gPZR0uFouhVl8UsOw">
+      <NeighborhoodBuilder id="TrZB-i4iX0ymTA32DziL3g" name="Pancreas_pls_Pancreas_int" mode="Logical" containerType="Neighborhood" firstNeighbor="-nHuc1cRH0moGvDmxl1hTw" secondNeighbor="TvORy5iMCky7sH4I0je24w">
         <Tags>
-          <Tag value="Neighborhood: Plasma / Plasma" />
+          <Tag value="Neighborhood: Plasma / Interstitial" />
         </Tags>
         <Children>
-          <Container id="uF2jl8qwm027qvYyl-bPkA" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="1xCEc6fy8EChuAd4RcKv_Q" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="0vrHQ8KFZka2Xw0DKD84xw" name="Mass transfer rate (mucosa to portal vein plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPvePlasma" isDefault="1" displayUnit="µmol/min">
-                <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
-                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+              <Parameter id="219oTQw9hkOki43UwRdPCQ" name="P (plasma&lt;-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
+                <ValueOrigin id="49" source="Other" method="Assumption" description="Assumption: very fast exchange" />
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="77" />
+              </Parameter>
+              <Parameter id="I0wFdYcbM0mlLCgEuCifdg" name="Partition coefficient (interstitial/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" isDefault="1">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="70" />
               </Parameter>
             </Children>
           </Container>
+          <Parameter id="vYOAeZgb3kut83aAxQA_yg" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" isDefault="1" displayUnit="cm²">
+            <Tags>
+              <Tag value="Neighborhood: Plasma / Interstitial" />
+            </Tags>
+            <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+            <Info min="0" flag="122" seq="13" ref="0" bb="32" group="106" />
+          </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="btHNBl9bXUGj6AXLATm8fg" name="Rectum_bc_PortalVein_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="82qs1z3BHkWv2WUqNvWppA" secondNeighbor="-ce4W1W9u0-sDuce1ufJ_A">
+      <NeighborhoodBuilder id="-AQHQXvZ-069Z4rIA9LLYQ" name="Pancreas_pls_PortalVein_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="-nHuc1cRH0moGvDmxl1hTw" secondNeighbor="vihskj6fJkaqqVik0r1DIg">
         <Tags>
-          <Tag value="Neighborhood: BloodCells / BloodCells" />
+          <Tag value="Neighborhood: Plasma / Plasma" />
+        </Tags>
+        <Children>
+          <Container id="D-hVjY5cXkSUJJNsVTg0fA" name="MoleculeProperties" mode="Logical" containerType="Other" />
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="Xo7n7k6-2kqafpn8RNlTkw" name="Lumen_rect_Rectum_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="UpSKgnWYPEiXklQNAqrFdg" secondNeighbor="54DFX1N5kkGUNRfAo0xMkw">
+        <Tags>
+          <Tag value="Neighborhood: Rectum / Plasma" />
         </Tags>
         <Children>
-          <Container id="EqVplybx90yQfuGSO2emJQ" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="kvQfqUXIe0SFmYvHftrWRw" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="fVRSJuAT_0-YoSY6XCUAFA" name="Mass transfer rate (mucosa to portal vein blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPveBloodCells" isDefault="1" displayUnit="µmol/min">
-                <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+              <Parameter id="aS2av5NYsUSI6fZOA4uh7w" name="Drug absorption rate (lumen to mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_DrugAbsorption_para" isDefault="1" displayUnit="µmol/min">
                 <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
               </Parameter>
+              <Parameter id="CxAJp_2Us0O8YpxkUB75XA" name="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" isDefault="1" displayUnit="µmol/min">
+                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
+              <Parameter id="eefiEbRoi0O5DHpoG7_5dQ" name="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" isDefault="1" displayUnit="µmol/min">
+                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
             </Children>
           </Container>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="apThlVv1n0qOQX7vduxO3A" name="Lumen_rect_Rectum_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="6fn_3RiggkS4UkuFhro8Dw" secondNeighbor="oTMjp1TYnUWpLJraDSSQMA">
+      <NeighborhoodBuilder id="vn7PoxyrQUuXir0KDpZbtg" name="Lumen_rect_Rectum_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="UpSKgnWYPEiXklQNAqrFdg" secondNeighbor="iIAVNSjiW0S2nzttLSTPAw">
         <Tags>
           <Tag value="Neighborhood: Rectum / Intracellular" />
         </Tags>
         <Children>
-          <Container id="geAsziRwwkq9LWswTHlznQ" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="OdL1OgEbLEygOpTsfEwfIg" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="pvnS8kCr6UGfXVrnJDi77g" name="pKa_pH_WS_cell_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F2" isDefault="1">
-                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
-              </Parameter>
-              <Parameter id="geKDsslrDUKkdXNJHUZd3A" name="Drug absorption rate (lumen to mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_DrugAbsorption_trans" isDefault="1" displayUnit="µmol/min">
+              <Parameter id="7f52ZbkKfUqomsAM5i3nTA" name="Drug absorption rate (lumen to mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_DrugAbsorption_trans" isDefault="1" displayUnit="µmol/min">
                 <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
               </Parameter>
-              <Parameter id="SI_dP443Gke9spGl9fek-A" name="P_int_trans_cell_lum_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_cell_lum_factor" isDefault="1">
+              <Parameter id="Lz0Mo-z4ZkisSpa6PVZ-0w" name="P_int_trans_cell_lum_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_cell_lum_factor" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="_ugPIMdi90aH61-_jhBUsA" name="P_int_trans_lum_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_lum_cell_factor" isDefault="1">
+              <Parameter id="M4AH2hcxtkmgSV5ZfR_ivQ" name="P_int_trans_lum_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_lum_cell_factor" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="1MTGv3kDmEWIPvie7XwOgQ" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_K_cell_pls_Rectum" isDefault="1">
+              <Parameter id="IjhHGdrOOUKew2MpYoHLmA" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_K_cell_pls_Rectum" isDefault="1">
                 <Info min="0" flag="36" seq="1" ref="0" bb="2" group="67" />
               </Parameter>
-              <Parameter id="vFXUcC75rkykS8PDVXWi6w" name="pKa_pH_WS_cell_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F1" isDefault="1">
+              <Parameter id="PzwPPvMrwUmhkSNoBSUSsg" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_Rectum" isDefault="1">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+              </Parameter>
+              <Parameter id="fldkhssZ0kGv3voofzr1Uw" name="pKa_pH_WS_cell_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F1" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="Ay3dlYvCdkuAZ8AF-Ipu3g" name="pKa_pH_WS_cell_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F3" isDefault="1">
+              <Parameter id="5gzrM-6ZKESOHw-5WYu0rQ" name="pKa_pH_WS_cell_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F2" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="gHeCJufvmk6VS4RDZRMOeA" name="pKa_pH_WS_cell_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K1" isDefault="1">
+              <Parameter id="PqGcw_g6O0WvR5ilOCxOoA" name="pKa_pH_WS_cell_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F3" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="P2dAbIIGDU6EvehJx7927Q" name="pKa_pH_WS_cell_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K2" isDefault="1">
+              <Parameter id="iXT1VmATKU6kk38MdbLsEQ" name="pKa_pH_WS_cell_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K1" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="5OTLefsW_USNQ8QLVZf7rw" name="pKa_pH_WS_cell_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K3" isDefault="1">
+              <Parameter id="heePLuIpVkediLna-xQNKg" name="pKa_pH_WS_cell_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K2" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="LrGHi1dyOUuBYQzyki8GGA" name="pKa_pH_WS_cell_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K4" isDefault="1">
+              <Parameter id="9OQ_ihzPTkOyKaI3XQfMJw" name="pKa_pH_WS_cell_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K3" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="nWkqdaPxfEu-DDt3kap2MQ" name="pKa_pH_WS_cell_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K5" isDefault="1">
+              <Parameter id="6JM107dmrkWV_O7FaKQN-A" name="pKa_pH_WS_cell_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K4" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="dT4Z3jaX0kSysjdQhnqBPQ" name="pKa_pH_WS_cell_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K6" isDefault="1">
+              <Parameter id="E7YK6RTbokqn65qeQYrmbg" name="pKa_pH_WS_cell_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K5" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="YIAkdcldOU-ZC0Q4anfNSQ" name="pKa_pH_WS_cell_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K7" isDefault="1">
+              <Parameter id="ohogpjabhkWSQVs0peuJYw" name="pKa_pH_WS_cell_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K6" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="kYiu0qz4wUm9sPJYVOTG_Q" name="pKa_pH_WS_cell_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K8" isDefault="1">
+              <Parameter id="E5FeSXEWbUSGhVdegmLncA" name="pKa_pH_WS_cell_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K7" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="6ueIh4eDCEuHp5ZOR18Kcg" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F1" isDefault="1">
+              <Parameter id="mMksH0eK3EWe6TUT93ccBA" name="pKa_pH_WS_cell_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K8" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="jFl31bhkI0GuZmGCJVvV2w" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F2" isDefault="1">
+              <Parameter id="aYcmaSzjYkuf9QozPAS8Wg" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F1" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="5xuZ96x8ikygp--P0-8fPQ" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_Rectum" isDefault="1">
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+              <Parameter id="-IIwS8D2uE6-jyaYoDTnlg" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F2" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="YEs9mii_VkSwB5pC4HW-hQ" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K2" isDefault="1">
+              <Parameter id="y7nD8t2N0kC-sK_57jk2VA" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F3" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="X3dVYsb_4UCueFOzAFzEwQ" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F3" isDefault="1">
+              <Parameter id="h-h2F4Mwwku7sJedDVCy4g" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K1" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="mMXm6fkAwkuQZqsWVbEyHQ" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K3" isDefault="1">
+              <Parameter id="cnAXWbgKuUymNJDHst_9ew" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K2" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="vGRmi3QV1kirm0A-dJlayA" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K4" isDefault="1">
+              <Parameter id="nI-I8mDWSk-vj_UOiINQvQ" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K3" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="SSgYRvL7ekq_HEr6eZXr6Q" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K5" isDefault="1">
+              <Parameter id="K5vHISukcUW74jOfpLb6jw" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K4" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="3U-4KhMk4UOF9a0u-cLIoA" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K6" isDefault="1">
+              <Parameter id="Vd92brsIZ0ifiTR4xy422Q" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K5" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="RS6ARkoFPkeEDQoFogtEDQ" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K7" isDefault="1">
+              <Parameter id="LYLEec7naUKxEzDjMgk4-Q" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K6" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="WzZSnu_XJkmcEjRPRQ9nmQ" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K8" isDefault="1">
+              <Parameter id="s1kFhn6S9k-gEjDiMtQ5xQ" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K7" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="sNoeQ2qLYEWxG1mI3fQ84Q" name="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" isDefault="1" displayUnit="µmol/min">
-                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+              <Parameter id="FW3o4F2azkOo19XUOzw1tw" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K8" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="bDZrnIZCEEi4dDDbQjUIGw" name="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" isDefault="1" displayUnit="µmol/min">
+              <Parameter id="cczDclp5sEqcSvZ4-lTpfg" name="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" isDefault="1" displayUnit="µmol/min">
                 <Info flag="52" seq="1" ref="0" bb="2" group="117" />
               </Parameter>
-              <Parameter id="7xdJmMn5E0Km8XhSRT6aSA" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K1" isDefault="1">
-                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              <Parameter id="NAzFtPyAckOGyb0tq7V-Vg" name="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" isDefault="1" displayUnit="µmol/min">
+                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
               </Parameter>
             </Children>
           </Container>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="OYsIOzN1EUO5w2pU2MKJeQ" name="Lumen_rect_Rectum_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="6fn_3RiggkS4UkuFhro8Dw" secondNeighbor="0Wkjd6C6ok-KS947nfXutA">
+      <NeighborhoodBuilder id="aYeV2l-mFUuKHi6GT00mMA" name="Rectum_pls_PortalVein_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="54DFX1N5kkGUNRfAo0xMkw" secondNeighbor="vihskj6fJkaqqVik0r1DIg">
         <Tags>
-          <Tag value="Neighborhood: Rectum / Plasma" />
+          <Tag value="Neighborhood: Plasma / Plasma" />
         </Tags>
         <Children>
-          <Container id="l6qEgUwlS0GoDXrItl4HhA" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="iVMYjiyD0kOwALfV1nI1Sw" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="vwldcjGKQkiZYMGs_1Cwgg" name="Drug absorption rate (lumen to mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_DrugAbsorption_para" isDefault="1" displayUnit="µmol/min">
+              <Parameter id="UtjjJ605oEWsfIu7RVht9A" name="Mass transfer rate (mucosa to portal vein plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPvePlasma" isDefault="1" displayUnit="µmol/min">
+                <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                 <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
               </Parameter>
-              <Parameter id="oXZ0US3hLEmQWw6MBFxFjg" name="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" isDefault="1" displayUnit="µmol/min">
-                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
-              </Parameter>
-              <Parameter id="J2FPO8u95U6-9igr4A4fqw" name="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" isDefault="1" displayUnit="µmol/min">
-                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+            </Children>
+          </Container>
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="A6LEVezIokeR8TdmagxfZA" name="Rectum_bc_PortalVein_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="ab5YKqDQeEe4od70TEbWtg" secondNeighbor="eN7tQLMOREG3-_sYJSczng">
+        <Tags>
+          <Tag value="Neighborhood: BloodCells / BloodCells" />
+        </Tags>
+        <Children>
+          <Container id="5E8PyttXBUe42Sb3v2B1tw" name="MoleculeProperties" mode="Logical" containerType="Other">
+            <Children>
+              <Parameter id="uIMr5UzogkyWfa488ShoDw" name="Mass transfer rate (mucosa to portal vein blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPveBloodCells" isDefault="1" displayUnit="µmol/min">
+                <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
               </Parameter>
             </Children>
           </Container>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="wAXXiial_U2VBE_WmpZ1ag" name="PortalVein_pls_PortalVein_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="meWL4gPZR0uFouhVl8UsOw" secondNeighbor="-ce4W1W9u0-sDuce1ufJ_A">
+      <NeighborhoodBuilder id="fkfViRNY1kGgE775K5Su9Q" name="PortalVein_pls_PortalVein_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="vihskj6fJkaqqVik0r1DIg" secondNeighbor="eN7tQLMOREG3-_sYJSczng">
         <Tags>
           <Tag value="Neighborhood: Plasma / BloodCells" />
         </Tags>
         <Children>
-          <Container id="V-jQuO5frEeT9zGF_KW_iA" name="MoleculeProperties" mode="Logical" containerType="Other" />
-          <Parameter id="okJ3si58JkGu8f0OJrCO-A" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls_Blood_Organ" isDefault="1" displayUnit="cm²">
+          <Container id="8NAp_6anvEWPsmSSAZ8MjQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Parameter id="Oxk8zEUSs0Oar0DviDOESw" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls_Blood_Organ" isDefault="1" displayUnit="cm²">
             <Tags>
               <Tag value="Neighborhood: Plasma / BloodCells" />
             </Tags>
@@ -16646,48 +16719,48 @@
           </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="XGKjptVBa0eSfbLt1-mBSA" name="Skin_bc_VenousBlood_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="JckXrn8BBEmHw5RRLETl1g" secondNeighbor="H3YIKhsT9kW_XjjpUkxqNg">
+      <NeighborhoodBuilder id="BlUKwqFOhEutDEzwJaK_kQ" name="Skin_bc_VenousBlood_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="FiOO7WH94EC7p9ETcLkZFQ" secondNeighbor="bHtbzf2QTkS9BPP8ck7mNg">
         <Tags>
           <Tag value="Neighborhood: BloodCells / BloodCells" />
         </Tags>
         <Children>
-          <Container id="r2exOsqHNkyWZQYbCll_2g" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="I-VxVVs-eEiycPLPs96r-Q" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="W9e4o6Za1EOHAr9E7QRyRA" name="Skin_int_Skin_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="vmdzgL34-kaI1ak4Lqb0rw" secondNeighbor="z8e4IZ7G70WspPLUgXgfVQ">
+      <NeighborhoodBuilder id="zcQeiOg7HEW7iRur6PJrFg" name="Skin_int_Skin_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="yhUUDIm81kiymhaQmxQkdQ" secondNeighbor="bahM5oUOqkWTknaxn5nfFg">
         <Tags>
           <Tag value="Neighborhood: Interstitial / Intracellular" />
         </Tags>
         <Children>
-          <Container id="HRI_J7y__UifkVouvQxiPQ" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="S007h3Ofh02xXC2bJVAlRQ" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="OU1H1ExLhU-SBpU0QC3EZg" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="69" />
-              </Parameter>
-              <Parameter id="kArXldYad0i39XPVGgG42w" name="P (interstitial-&gt;intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" isDefault="1" displayUnit="cm/min">
+              <Parameter id="xYWgvGc5tUehU58MmisV-g" name="P (interstitial-&gt;intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" isDefault="1" displayUnit="cm/min">
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="78" />
               </Parameter>
-              <Parameter id="fdEnp6YH4EuQkyY2gA6y4A" name="P (intracellular-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" isDefault="1" displayUnit="cm/min">
+              <Parameter id="i2Av1xnRckCfUQPtHTpe3g" name="P (intracellular-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" isDefault="1" displayUnit="cm/min">
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="76" />
               </Parameter>
-              <Parameter id="2nIga_C8yUaxYiCf83dQCA" name="P*SA interstitial -&gt; intracellular" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" isDefault="1" displayUnit="l/min">
+              <Parameter id="Df1jfvt8k0GZBtSYCzXOPw" name="P*SA interstitial -&gt; intracellular" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" isDefault="1" displayUnit="l/min">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="IPUHSv24MEeOzlohyL6VxQ" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
+              <Parameter id="gLQOGhCftkiZB0tfHdBOyw" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="Ad6c2hi-W0KiHhmollP3xA" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
+              <Parameter id="xwPfhhboCEyGKjvjGFciNQ" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="_tC3fKKI-EuOi1eyMEgQmQ" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
-              </Parameter>
-              <Parameter id="Hfs18_yNLkiaq6ysX9CLzA" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
+              <Parameter id="AbKGUBN1nUSFG5eWSJ13_Q" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
+              <Parameter id="mQN4kJW4yk2IuP9TEfCkaA" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="69" />
+              </Parameter>
+              <Parameter id="39xSw1Ukm02Kya58pZ1udA" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+              </Parameter>
             </Children>
           </Container>
-          <Parameter id="3OocuIgfHkGNt3e5bv_l0g" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_skn" isDefault="1" displayUnit="cm²">
+          <Parameter id="ba5d7VgCWEyt649iE352-w" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_skn" isDefault="1" displayUnit="cm²">
             <Tags>
               <Tag value="Neighborhood: Interstitial / Intracellular" />
             </Tags>
@@ -16695,23 +16768,37 @@
           </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="EH0KrSFG4kipXyefB3UmKA" name="Skin_pls_Skin_int" mode="Logical" containerType="Neighborhood" firstNeighbor="TBOCHId7jEytRA-_hVQFnA" secondNeighbor="vmdzgL34-kaI1ak4Lqb0rw">
+      <NeighborhoodBuilder id="eKq-nzVhyEmEMmor3XD6Xg" name="Skin_pls_Skin_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="kO0daEk3LUG7zEtqAh9fyQ" secondNeighbor="FiOO7WH94EC7p9ETcLkZFQ">
+        <Tags>
+          <Tag value="Neighborhood: Plasma / BloodCells" />
+        </Tags>
+        <Children>
+          <Container id="DTjC8WNIL0uW9TkH4qeFiA" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Parameter id="T5HdXzqk_E2_8pKBnGmuuQ" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" isDefault="1" displayUnit="cm²">
+            <Tags>
+              <Tag value="Neighborhood: Plasma / BloodCells" />
+            </Tags>
+            <Info min="0" flag="122" seq="17" ref="0" bb="32" group="104" />
+          </Parameter>
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="MonMOKJyjESrKDkfQCPcJA" name="Skin_pls_Skin_int" mode="Logical" containerType="Neighborhood" firstNeighbor="kO0daEk3LUG7zEtqAh9fyQ" secondNeighbor="yhUUDIm81kiymhaQmxQkdQ">
         <Tags>
           <Tag value="Neighborhood: Plasma / Interstitial" />
         </Tags>
         <Children>
-          <Container id="Yk0dJqDqyEyA-PVBsGnRNQ" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="Fjiwymmk9EiuGWiU-OzAyg" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="v36z-p73UUiYB17wfhGA5A" name="P (plasma&lt;-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
-                <ValueOrigin id="49" method="Assumption" description="TODO: Default: very fast exchange" />
+              <Parameter id="B-7iHyX-60ukFhtI-dYehw" name="P (plasma&lt;-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
+                <ValueOrigin id="49" source="Other" method="Assumption" description="Assumption: very fast exchange" />
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="77" />
               </Parameter>
-              <Parameter id="v_9SFGvmOEaM1FvYXy0seQ" name="Partition coefficient (interstitial/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" isDefault="1">
+              <Parameter id="yxmycMmIHEWNnTrVpjJEUg" name="Partition coefficient (interstitial/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" isDefault="1">
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="70" />
               </Parameter>
             </Children>
           </Container>
-          <Parameter id="4aKXBdviz0KQTxP6qQsCJQ" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" isDefault="1" displayUnit="cm²">
+          <Parameter id="M-1RcC9SZU23nux3FQSUdg" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" isDefault="1" displayUnit="cm²">
             <Tags>
               <Tag value="Neighborhood: Plasma / Interstitial" />
             </Tags>
@@ -16720,70 +16807,56 @@
           </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="kwFwBBG7I0K8QQfw27mM4A" name="Skin_pls_Skin_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="TBOCHId7jEytRA-_hVQFnA" secondNeighbor="JckXrn8BBEmHw5RRLETl1g">
-        <Tags>
-          <Tag value="Neighborhood: Plasma / BloodCells" />
-        </Tags>
-        <Children>
-          <Container id="dOsK1hdeN0iYTebJaDbshw" name="MoleculeProperties" mode="Logical" containerType="Other" />
-          <Parameter id="cVohlobLsUC7tbuAT12RWQ" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" isDefault="1" displayUnit="cm²">
-            <Tags>
-              <Tag value="Neighborhood: Plasma / BloodCells" />
-            </Tags>
-            <Info min="0" flag="122" seq="17" ref="0" bb="32" group="104" />
-          </Parameter>
-        </Children>
-      </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="iFwukcJ2dEaNhrxcS4STBw" name="Skin_pls_VenousBlood_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="TBOCHId7jEytRA-_hVQFnA" secondNeighbor="dt7fUpCxbUGcr9pNef8UCA">
+      <NeighborhoodBuilder id="wYEB083tQ0GfiJghpG_myA" name="Skin_pls_VenousBlood_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="kO0daEk3LUG7zEtqAh9fyQ" secondNeighbor="Ans5EKfuF0W1dnzkXjqTlg">
         <Tags>
           <Tag value="Neighborhood: Plasma / Plasma" />
         </Tags>
         <Children>
-          <Container id="vKXhDWgra0qj7MET-8aH9w" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="Wbz7P4ISdkanGo9xNz6bUA" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="YpCp0wF6sU2U7UW5wTpNPA" name="Spleen_bc_PortalVein_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="_ODIQVUzQ0K4jpX5ZvTqSQ" secondNeighbor="-ce4W1W9u0-sDuce1ufJ_A">
+      <NeighborhoodBuilder id="m36ME0pNc0y0RPFed3Chtw" name="Spleen_bc_PortalVein_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="RA_8UNeBWESbhO5VGxlmJQ" secondNeighbor="eN7tQLMOREG3-_sYJSczng">
         <Tags>
           <Tag value="Neighborhood: BloodCells / BloodCells" />
         </Tags>
         <Children>
-          <Container id="RTDG7Q-u9US6itCHqenxDw" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="RSr6MS7C30CO34_Ujqon_g" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="XK2mboweeUui19B6w-eeCw" name="Spleen_int_Spleen_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="dlChF3uuTkmSjaAd9CO4kQ" secondNeighbor="AGWNI3Ljd0WcM_03CFF0sw">
+      <NeighborhoodBuilder id="s0yQH5afIk6YYNZvP0OI_Q" name="Spleen_int_Spleen_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="zHIfOC2pM0SJwS2KKwWs3w" secondNeighbor="sKUC-8g1Rk-cxsf33UKcZg">
         <Tags>
           <Tag value="Neighborhood: Interstitial / Intracellular" />
         </Tags>
         <Children>
-          <Container id="YX1axmAelUi538DTgutjTA" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="LjlqVT_lxUSqWElUQvDaPQ" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="OIlbr3BHwUuddij3UN8uyg" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
+              <Parameter id="IA-bTqlBS0yoBMBaPfAaBw" name="P (interstitial-&gt;intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" isDefault="1" displayUnit="cm/min">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="78" />
+              </Parameter>
+              <Parameter id="L6pqu5wL-UqvP3Ai5pdtjQ" name="P (intracellular-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" isDefault="1" displayUnit="cm/min">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="76" />
+              </Parameter>
+              <Parameter id="EehB17QXgESgYtnkFfpXPQ" name="P*SA interstitial -&gt; intracellular" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" isDefault="1" displayUnit="l/min">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="l220f81K50G_-im8UyZ_sw" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="6r8nCJozSkOUwV3w2Vq6gw" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
+              <Parameter id="bgJGwL56jUWwFZgx_QVqBw" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="j_WUwLIt4EypB0GdFh5Vjw" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
+              <Parameter id="hNsV0QQVjE-QKtB7VIS7hw" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="fpuW9jVfck2eCVHRisCN5A" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
+              <Parameter id="Zj09-AT7GUy-KDRra3RdkA" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="69" />
               </Parameter>
-              <Parameter id="mbmDhe4ekEKtPSyLYPcfOQ" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
+              <Parameter id="9No069N3sUyv8Eo8b6DzMw" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
               </Parameter>
-              <Parameter id="OQuDQBBmcU-Ri19hQ0ZXSg" name="P (intracellular-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" isDefault="1" displayUnit="cm/min">
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="76" />
-              </Parameter>
-              <Parameter id="wM79LQDQQUiMr9EEVK9hPg" name="P (interstitial-&gt;intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" isDefault="1" displayUnit="cm/min">
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="78" />
-              </Parameter>
-              <Parameter id="7wpauoewyE6f5QV4rYyphw" name="P*SA interstitial -&gt; intracellular" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" isDefault="1" displayUnit="l/min">
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
-              </Parameter>
             </Children>
           </Container>
-          <Parameter id="KWyrITj3lkeizIYi7X6hJw" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_spl" isDefault="1" displayUnit="cm²">
+          <Parameter id="oZ3RzO_AR0ywZTOMOYegqQ" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_spl" isDefault="1" displayUnit="cm²">
             <Tags>
               <Tag value="Neighborhood: Interstitial / Intracellular" />
             </Tags>
@@ -16791,21 +16864,21 @@
           </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="XMvaKgPtpEuYn_0Lr3dz4A" name="Spleen_pls_PortalVein_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="ACfXTDO_GUup1aBj-xeGyg" secondNeighbor="meWL4gPZR0uFouhVl8UsOw">
+      <NeighborhoodBuilder id="n_NubEFg-kS5xpNckDYewg" name="Spleen_pls_PortalVein_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="PF2p7IEtQ0aLG7Gj7WfJcw" secondNeighbor="vihskj6fJkaqqVik0r1DIg">
         <Tags>
           <Tag value="Neighborhood: Plasma / Plasma" />
         </Tags>
         <Children>
-          <Container id="bXH8zFREWUe1YOUlnG7Dvg" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="KUerbi--CE2S9hsGHwtvbg" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="5aONN20PkEaJyV7m4eaKzA" name="Spleen_pls_Spleen_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="ACfXTDO_GUup1aBj-xeGyg" secondNeighbor="_ODIQVUzQ0K4jpX5ZvTqSQ">
+      <NeighborhoodBuilder id="1F5IL55PnUWvqPesk0GZdw" name="Spleen_pls_Spleen_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="PF2p7IEtQ0aLG7Gj7WfJcw" secondNeighbor="RA_8UNeBWESbhO5VGxlmJQ">
         <Tags>
           <Tag value="Neighborhood: Plasma / BloodCells" />
         </Tags>
         <Children>
-          <Container id="22lPo6Iiv0yUGSN2GEZa0w" name="MoleculeProperties" mode="Logical" containerType="Other" />
-          <Parameter id="KLtb6S6al0qQKqdHJu5qXg" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" isDefault="1" displayUnit="cm²">
+          <Container id="1oXYKjvoxUaYVi9bz25WIA" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Parameter id="91_OcSZGs0qW-L4GXPHQ_Q" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" isDefault="1" displayUnit="cm²">
             <Tags>
               <Tag value="Neighborhood: Plasma / BloodCells" />
             </Tags>
@@ -16813,23 +16886,23 @@
           </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="dbTtYvJlck-IThKBLPFBTw" name="Spleen_pls_Spleen_int" mode="Logical" containerType="Neighborhood" firstNeighbor="ACfXTDO_GUup1aBj-xeGyg" secondNeighbor="dlChF3uuTkmSjaAd9CO4kQ">
+      <NeighborhoodBuilder id="CSiZi_-k20y-LzHaRvxfQQ" name="Spleen_pls_Spleen_int" mode="Logical" containerType="Neighborhood" firstNeighbor="PF2p7IEtQ0aLG7Gj7WfJcw" secondNeighbor="zHIfOC2pM0SJwS2KKwWs3w">
         <Tags>
           <Tag value="Neighborhood: Plasma / Interstitial" />
         </Tags>
         <Children>
-          <Container id="clOmhkvzrkeFJWHRfKusPw" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="jPePFAXdv0aEgqPDFCV05Q" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="jH7Ny4woRkqzMeJ4Lc75Rw" name="Partition coefficient (interstitial/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" isDefault="1">
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="70" />
-              </Parameter>
-              <Parameter id="qJxA5kXNOkudCh2cmiQvIQ" name="P (plasma&lt;-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
-                <ValueOrigin id="49" method="Assumption" description="TODO: Default: very fast exchange" />
+              <Parameter id="opZKAsFJKUS6RcADedjl9g" name="P (plasma&lt;-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
+                <ValueOrigin id="49" source="Other" method="Assumption" description="Assumption: very fast exchange" />
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="77" />
               </Parameter>
+              <Parameter id="6grbHTVGXUyNmXgmguz3Qw" name="Partition coefficient (interstitial/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" isDefault="1">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="70" />
+              </Parameter>
             </Children>
           </Container>
-          <Parameter id="hRHcI5kzvkuJzel_peSKNQ" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" isDefault="1" displayUnit="cm²">
+          <Parameter id="5inGEOGpnEeQkt5jLcmNvg" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" isDefault="1" displayUnit="cm²">
             <Tags>
               <Tag value="Neighborhood: Plasma / Interstitial" />
             </Tags>
@@ -16838,59 +16911,75 @@
           </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="S2BzlUMj_k6M5eFgqWSkfA" name="Saliva_slv_Saliva_slv" mode="Logical" containerType="Neighborhood" firstNeighbor="5VuD3ziLfkmZY1N6j19UqQ" secondNeighbor="r3H-bXZqRkuVBco8BmNJew">
+      <NeighborhoodBuilder id="yTD_UaBRKUi6Y5GOxFteDw" name="Saliva_slv_Saliva_slv" mode="Logical" containerType="Neighborhood" firstNeighbor="5BYlVgrFyEuRdgI2oyIivQ" secondNeighbor="MCXQfuQSpEighJ3SjBrx_g">
         <Tags>
           <Tag value="Neighborhood: SalivaGland / Saliva" />
         </Tags>
         <Children>
-          <Container id="avOQdzflKE2wcvpF8N9uaw" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="zX8yCA2hjk2WG7VeOpBufw" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="nl2IpOGW7Uq4kXsrqkpueg" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionSaliva_PKSim.PARAM_K_cell_pls_slv" isDefault="1">
+              <Parameter id="uMV4Yu7jOEW1XWGNfRUN-w" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionSaliva_PKSim.PARAM_K_cell_pls_slv" isDefault="1">
                 <ValueOrigin id="43" source="Internet" description="Willi Cawello. Pharmacokinetics and bioavailability derived from various body fluids. http://www.agah.eu/fileadmin/_migrated/content_uploads/W._Cawello__2__25.05.07.pdf" />
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="69" />
               </Parameter>
-              <Parameter id="-uyJtYKKqUCIzNhkurFmrg" name="SalivaPlasmaRatio" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionSaliva_PKSim.PARAM_SalivaPlasmaRatio" isDefault="1">
+              <Parameter id="zwZXdnn14km50v5f9_tBLQ" name="SalivaPlasmaRatio" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionSaliva_PKSim.PARAM_SalivaPlasmaRatio" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="22" />
               </Parameter>
             </Children>
           </Container>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="gZg3zFmJHUWrK0J7eq4omA" name="Duodenum_pls_Duodenum_int" mode="Logical" containerType="Neighborhood" firstNeighbor="3_a1oSiNnkisFIFOu3c1zw" secondNeighbor="J3QDFPH38kedxiBgEqHhwg">
+      <NeighborhoodBuilder id="zitXBMT_V06dty1tMticlg" name="Duodenum_int_Duodenum_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="u56c8ZXo-EiW0xWduMkC5g" secondNeighbor="zbImQfwyxkWPq_gPbXufRw">
         <Tags>
-          <Tag value="Neighborhood: Plasma / Interstitial" />
+          <Tag value="Neighborhood: Interstitial / Intracellular" />
           <Tag value="Small intestine  neighborhood" />
         </Tags>
         <Children>
-          <Container id="N1qv6ut5k0Sn2Dg1bZz7fA" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="M2bP2WjsK0i2ZRIhEDgdhw" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="6G0wNzw7XUCa2L1JMv6LMA" name="Partition coefficient (interstitial/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" isDefault="1">
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="148" />
+              <Parameter id="yca-d_2tDEWE4_GRznf8gw" name="P (interstitial-&gt;intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_int_cell_Mucosa" isDefault="1" displayUnit="cm/min">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="135" />
               </Parameter>
-              <Parameter id="UWr1Nr7Tv0ed3ZrSj0yP-A" name="P (plasma&lt;-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
-                <ValueOrigin id="49" method="Assumption" description="TODO: Default: very fast exchange" />
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="134" />
+              <Parameter id="4MnZhkWOcEen92i5Koy46A" name="P (intracellular-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_cell_int_Mucosa" isDefault="1" displayUnit="cm/min">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="133" />
+              </Parameter>
+              <Parameter id="hSFWWec-gkGh0l46uzh2Ig" name="P*SA interstitial -&gt; intracellular" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" isDefault="1" displayUnit="l/min">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="FI390adql0mSPJejHDc7JA" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="vVyyv-Efx0muQwpONthJNw" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="51PdAetyc0aRE_o66yTgRg" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="mq4CY0kA_UeiA-BTquTQwA" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="147" />
+              </Parameter>
+              <Parameter id="CdeXpzvCakOwunDJvM3DOw" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
               </Parameter>
             </Children>
           </Container>
-          <Parameter id="ziDx66110k6koJiTSSypjQ" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" isDefault="1" displayUnit="cm²">
+          <Parameter id="_N2Kt94Q7EGK7v1Sa5KWKA" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mucosa_duo" isDefault="1" displayUnit="cm²">
             <Tags>
-              <Tag value="Neighborhood: Plasma / Interstitial" />
+              <Tag value="Neighborhood: Interstitial / Intracellular" />
               <Tag value="Small intestine  neighborhood" />
             </Tags>
-            <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-            <Info min="0" flag="122" seq="18" ref="0" bb="32" group="106" />
+            <Info min="0" flag="122" seq="18" ref="0" bb="32" group="105" />
           </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="rwql-76R4Ue_n96hg7Ew4A" name="Duodenum_pls_Duodenum_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="3_a1oSiNnkisFIFOu3c1zw" secondNeighbor="H5K_385D-UCbaUAkVzKFPA">
+      <NeighborhoodBuilder id="nB6Hns-KikOcRAHXG2_BcA" name="Duodenum_pls_Duodenum_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="C-d2PMLTSE2CX0a7o185GA" secondNeighbor="nwFYd1vNG0uI8cY3lrK-Zw">
         <Tags>
           <Tag value="Neighborhood: Plasma / BloodCells" />
           <Tag value="Small intestine  neighborhood" />
         </Tags>
         <Children>
-          <Container id="p5-xwKXGXE2AFcmqgmYeBA" name="MoleculeProperties" mode="Logical" containerType="Other" />
-          <Parameter id="FWT_04HBoUWagGSDN13gvQ" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" isDefault="1" displayUnit="cm²">
+          <Container id="jBhFRMf9N0Cg770cRn0EVw" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Parameter id="Rmwn1tjuXkO_ah1STzRX-g" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" isDefault="1" displayUnit="cm²">
             <Tags>
               <Tag value="Neighborhood: Plasma / BloodCells" />
               <Tag value="Small intestine  neighborhood" />
@@ -16899,57 +16988,84 @@
           </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="a2D_p_HP8U6LqoGbJUyV6g" name="Duodenum_int_Duodenum_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="J3QDFPH38kedxiBgEqHhwg" secondNeighbor="PdhUdIESUEalieeUeCgevg">
+      <NeighborhoodBuilder id="-qTY-DAmhk2QSYHvZgzQBQ" name="Duodenum_pls_Duodenum_int" mode="Logical" containerType="Neighborhood" firstNeighbor="C-d2PMLTSE2CX0a7o185GA" secondNeighbor="u56c8ZXo-EiW0xWduMkC5g">
         <Tags>
-          <Tag value="Neighborhood: Interstitial / Intracellular" />
+          <Tag value="Neighborhood: Plasma / Interstitial" />
           <Tag value="Small intestine  neighborhood" />
         </Tags>
         <Children>
-          <Container id="ZPYXbnh70Uyq_yVPwtQ4iw" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="vrHTB6lVU0-8wpZrbLyxtQ" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="xuTS_8IKx0G_evCZ-kQt4A" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+              <Parameter id="tuPTdWs3UEa0-GTzvtHhrw" name="P (plasma&lt;-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
+                <ValueOrigin id="49" source="Other" method="Assumption" description="Assumption: very fast exchange" />
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="134" />
+              </Parameter>
+              <Parameter id="4Ky7QwuCWkaO7MO73dSl6Q" name="Partition coefficient (interstitial/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" isDefault="1">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="148" />
               </Parameter>
-              <Parameter id="T1soYORZpkyMKjeQ3v3yqA" name="P (interstitial-&gt;intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_int_cell_Mucosa" isDefault="1" displayUnit="cm/min">
+            </Children>
+          </Container>
+          <Parameter id="dwGxOrrSV0WYyjEw1IMv3A" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" isDefault="1" displayUnit="cm²">
+            <Tags>
+              <Tag value="Neighborhood: Plasma / Interstitial" />
+              <Tag value="Small intestine  neighborhood" />
+            </Tags>
+            <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+            <Info min="0" flag="122" seq="18" ref="0" bb="32" group="106" />
+          </Parameter>
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="0b5xPMbNJE-nOs1BICARYA" name="UpperJejunum_int_UpperJejunum_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="LWvKqL4dm0yxsghkJ8nxdw" secondNeighbor="sydFGAeVT0OsnWNbGigz6A">
+        <Tags>
+          <Tag value="Neighborhood: Interstitial / Intracellular" />
+          <Tag value="Small intestine  neighborhood" />
+        </Tags>
+        <Children>
+          <Container id="OFRyyOn3vkCDs9mC-h4UgQ" name="MoleculeProperties" mode="Logical" containerType="Other">
+            <Children>
+              <Parameter id="SkcKHP1wEUqMgLjLA_H_FA" name="P (interstitial-&gt;intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_int_cell_Mucosa" isDefault="1" displayUnit="cm/min">
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="135" />
               </Parameter>
-              <Parameter id="JiO9JuhtC0aErWxsCCAj5Q" name="P (intracellular-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_cell_int_Mucosa" isDefault="1" displayUnit="cm/min">
+              <Parameter id="V_Fc8XKA8kyS05pdeEycpw" name="P (intracellular-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_cell_int_Mucosa" isDefault="1" displayUnit="cm/min">
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="133" />
               </Parameter>
-              <Parameter id="1AgDSwHs30SztHH6iIWdZw" name="P*SA interstitial -&gt; intracellular" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" isDefault="1" displayUnit="l/min">
+              <Parameter id="GFLkzVZXHUSNQ2T3nrdjIQ" name="P*SA interstitial -&gt; intracellular" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" isDefault="1" displayUnit="l/min">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="hxIRkBFPF0uiFVvKFhiDcw" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="3Nd9cxxlvUeUirGVIAhpoA" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
+              <Parameter id="UugkY2vKFki4PFubJV5NlQ" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="UOb07dHE70e3JFjHq-lSMg" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
+              <Parameter id="naJsqXMRI0WC-I4QEHK1og" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="j9GFIekZ3USEwRxT3TZ11w" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
+              <Parameter id="5qlhSU5vU0WRxXuXzSJ7HA" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="147" />
               </Parameter>
-              <Parameter id="0FGEDjrYnke4iV_WoeBvYQ" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+              <Parameter id="Tp7BPfZm4kuLAdWm9a7kMQ" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
               </Parameter>
             </Children>
           </Container>
-          <Parameter id="UUqhENBauUuSIzc8sfR-tQ" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mucosa_duo" isDefault="1" displayUnit="cm²">
+          <Parameter id="lNZG1ztLiEqeSyo-anE-aw" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mucosa_uje" isDefault="1" displayUnit="cm²">
             <Tags>
               <Tag value="Neighborhood: Interstitial / Intracellular" />
               <Tag value="Small intestine  neighborhood" />
             </Tags>
-            <Info min="0" flag="122" seq="18" ref="0" bb="32" group="105" />
+            <Info min="0" flag="122" seq="19" ref="0" bb="32" group="105" />
           </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="dhv-SU6p_UG0g3PV7sJCkA" name="UpperJejunum_pls_UpperJejunum_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="zSjCQfE2ukibuVnEq9IN8w" secondNeighbor="r_MPzXq0uk2PEXKKnd-O8w">
+      <NeighborhoodBuilder id="tRgtkszEq0q2245yetsveA" name="UpperJejunum_pls_UpperJejunum_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="4CbOfy3paECKcKT3NoWL2w" secondNeighbor="2tcy-Ya4DkapvK5NMu6LXQ">
         <Tags>
           <Tag value="Neighborhood: Plasma / BloodCells" />
           <Tag value="Small intestine  neighborhood" />
         </Tags>
         <Children>
-          <Container id="Wreaic7pdEmzeDgcQYlrNw" name="MoleculeProperties" mode="Logical" containerType="Other" />
-          <Parameter id="VGQIQhPQbE6bUZnMn94DTA" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" isDefault="1" displayUnit="cm²">
+          <Container id="9Yoqiw_6X0WUirEl0EgcRA" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Parameter id="lGGFCBtMJ0KeN_g3qOBrtg" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" isDefault="1" displayUnit="cm²">
             <Tags>
               <Tag value="Neighborhood: Plasma / BloodCells" />
               <Tag value="Small intestine  neighborhood" />
@@ -16958,24 +17074,24 @@
           </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="Xgu-txeaRkqTtGsMBpTcXw" name="UpperJejunum_pls_UpperJejunum_int" mode="Logical" containerType="Neighborhood" firstNeighbor="zSjCQfE2ukibuVnEq9IN8w" secondNeighbor="E9EWxPgQP02hXkkQIXV8uw">
+      <NeighborhoodBuilder id="zROC1gRxx0inZTKLBsOeRA" name="UpperJejunum_pls_UpperJejunum_int" mode="Logical" containerType="Neighborhood" firstNeighbor="4CbOfy3paECKcKT3NoWL2w" secondNeighbor="LWvKqL4dm0yxsghkJ8nxdw">
         <Tags>
           <Tag value="Neighborhood: Plasma / Interstitial" />
           <Tag value="Small intestine  neighborhood" />
         </Tags>
         <Children>
-          <Container id="jTjgTHeN5UOdYZnw3XVk1w" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="ZyxKfdx3T0yqSeAYaBuawA" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="ghy80BQvGkSCbQxvu2d9yg" name="Partition coefficient (interstitial/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" isDefault="1">
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="148" />
-              </Parameter>
-              <Parameter id="hhoAqnL1o0qdVZQnPohr-w" name="P (plasma&lt;-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
-                <ValueOrigin id="49" method="Assumption" description="TODO: Default: very fast exchange" />
+              <Parameter id="NylyLLJ6Pkq0_rb_zYfDEg" name="P (plasma&lt;-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
+                <ValueOrigin id="49" source="Other" method="Assumption" description="Assumption: very fast exchange" />
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="134" />
               </Parameter>
+              <Parameter id="dT3WwGw2Q0agYkX9m1_r6g" name="Partition coefficient (interstitial/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" isDefault="1">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="148" />
+              </Parameter>
             </Children>
           </Container>
-          <Parameter id="mT-2Jv1Qf0OGRl1jIZZ1Fw" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" isDefault="1" displayUnit="cm²">
+          <Parameter id="thVb9KwhQ0ytLibD0Exa0Q" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" isDefault="1" displayUnit="cm²">
             <Tags>
               <Tag value="Neighborhood: Plasma / Interstitial" />
               <Tag value="Small intestine  neighborhood" />
@@ -16985,196 +17101,169 @@
           </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="e_gtHeDQukOTmmrfVqM-iA" name="UpperJejunum_int_UpperJejunum_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="E9EWxPgQP02hXkkQIXV8uw" secondNeighbor="CcO7OCe_ME-7FudeoxVNtA">
+      <NeighborhoodBuilder id="AxuteLTiMkuUDrwdsKyrIA" name="LowerJejunum_int_LowerJejunum_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="UQ_qU6QMZUaTyT5su0zOcw" secondNeighbor="ZVzsDd2s6USCvF5KFRacyQ">
         <Tags>
           <Tag value="Neighborhood: Interstitial / Intracellular" />
           <Tag value="Small intestine  neighborhood" />
         </Tags>
         <Children>
-          <Container id="A3oo3D83yUeskPqDGARMHg" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="t8cn-wXZFkOlqPxcnina7A" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="49Eew6PioU23cy-YqJKv1g" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
-              </Parameter>
-              <Parameter id="knp1dZCThU60kPJTxJ6bKg" name="P (interstitial-&gt;intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_int_cell_Mucosa" isDefault="1" displayUnit="cm/min">
+              <Parameter id="HwK0FbrPckOFaJ_r__l3iA" name="P (interstitial-&gt;intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_int_cell_Mucosa" isDefault="1" displayUnit="cm/min">
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="135" />
               </Parameter>
-              <Parameter id="A1DzA8F8HEys-NuQ-wnT2g" name="P (intracellular-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_cell_int_Mucosa" isDefault="1" displayUnit="cm/min">
+              <Parameter id="xt2gIXNjfkSLgNbPa5rSSQ" name="P (intracellular-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_cell_int_Mucosa" isDefault="1" displayUnit="cm/min">
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="133" />
               </Parameter>
-              <Parameter id="mEOW_WJXXESxbXTpZYPYsQ" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
+              <Parameter id="0-3RHpX2dUyf0LgbOp8dmg" name="P*SA interstitial -&gt; intracellular" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" isDefault="1" displayUnit="l/min">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="igs8r-G1_0mQc4GaPZR40A" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="A7SHDtf9LkKCeKoLd0dtYA" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
+              <Parameter id="HuX0uTnnX0-C0_SVZvzdsg" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="etiDkMbU60S5uaHfVFjg3g" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
+              <Parameter id="csrvuzffpEe7WbLsZnBjUw" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="d5YF1tVQ2U2Iqp6QcsM53A" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="147" />
               </Parameter>
-              <Parameter id="mVv7DeOWZUOGXAbFjKztiQ" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
+              <Parameter id="4UMW7DZgCUmGkVEOi98QbA" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
               </Parameter>
-              <Parameter id="WRz_BWWcBEyI7xA4DnLyqA" name="P*SA interstitial -&gt; intracellular" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" isDefault="1" displayUnit="l/min">
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
-              </Parameter>
             </Children>
           </Container>
-          <Parameter id="04jRgqT5M0a54BEdulhKNg" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mucosa_uje" isDefault="1" displayUnit="cm²">
+          <Parameter id="raCDMYXDGEaqe5w1sPI0dQ" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mucosa_lje" isDefault="1" displayUnit="cm²">
             <Tags>
               <Tag value="Neighborhood: Interstitial / Intracellular" />
               <Tag value="Small intestine  neighborhood" />
             </Tags>
-            <Info min="0" flag="122" seq="19" ref="0" bb="32" group="105" />
+            <Info min="0" flag="122" seq="20" ref="0" bb="32" group="105" />
           </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="Yip8uajS-0GUAO_9P-xvzw" name="LowerJejunum_pls_LowerJejunum_int" mode="Logical" containerType="Neighborhood" firstNeighbor="zrKtW28pvEStr3uQ0NWXgQ" secondNeighbor="5nN5NiM1M0K5ZU2nRPNl_Q">
+      <NeighborhoodBuilder id="1aUWaaInCUu3egUYrIT9qg" name="LowerJejunum_pls_LowerJejunum_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="_vxo4wcBG0Spf1REJOKECA" secondNeighbor="K659GHjLpkKqC6Y--ONvog">
         <Tags>
-          <Tag value="Neighborhood: Plasma / Interstitial" />
+          <Tag value="Neighborhood: Plasma / BloodCells" />
           <Tag value="Small intestine  neighborhood" />
         </Tags>
         <Children>
-          <Container id="ckf-mITxskq_KhPyYMwbLA" name="MoleculeProperties" mode="Logical" containerType="Other">
-            <Children>
-              <Parameter id="J9lTxf907EaOLsAkW24-8g" name="Partition coefficient (interstitial/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" isDefault="1">
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="148" />
-              </Parameter>
-              <Parameter id="KADIk7FkVUytg37f62kq-A" name="P (plasma&lt;-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
-                <ValueOrigin id="49" method="Assumption" description="TODO: Default: very fast exchange" />
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="134" />
-              </Parameter>
-            </Children>
-          </Container>
-          <Parameter id="beb4d0tG_k-joM0uHFbpug" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" isDefault="1" displayUnit="cm²">
+          <Container id="t8ITooXKvE6pmvuOyEDCPA" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Parameter id="jadTwPrtlUe_kctdU_la6g" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" isDefault="1" displayUnit="cm²">
             <Tags>
-              <Tag value="Neighborhood: Plasma / Interstitial" />
+              <Tag value="Neighborhood: Plasma / BloodCells" />
               <Tag value="Small intestine  neighborhood" />
             </Tags>
-            <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-            <Info min="0" flag="122" seq="20" ref="0" bb="32" group="106" />
+            <Info min="0" flag="122" seq="23" ref="0" bb="32" group="104" />
           </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="zR0dIURwFUmyoOciIoLK3Q" name="LowerJejunum_pls_LowerJejunum_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="zrKtW28pvEStr3uQ0NWXgQ" secondNeighbor="Wda4ndmPT0GokpTDOLelAw">
+      <NeighborhoodBuilder id="Xmy4bM-REE-RLZFbvchoLw" name="LowerJejunum_pls_LowerJejunum_int" mode="Logical" containerType="Neighborhood" firstNeighbor="_vxo4wcBG0Spf1REJOKECA" secondNeighbor="UQ_qU6QMZUaTyT5su0zOcw">
         <Tags>
-          <Tag value="Neighborhood: Plasma / BloodCells" />
+          <Tag value="Neighborhood: Plasma / Interstitial" />
           <Tag value="Small intestine  neighborhood" />
         </Tags>
         <Children>
-          <Container id="e3MEaNEHgUeh4o6tTB7ypA" name="MoleculeProperties" mode="Logical" containerType="Other" />
-          <Parameter id="6UNkDkT2dUKLVMglYi6HYA" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" isDefault="1" displayUnit="cm²">
+          <Container id="SUapWrK7OEKVILRdXUyzmg" name="MoleculeProperties" mode="Logical" containerType="Other">
+            <Children>
+              <Parameter id="aY3S80nuSECn_f8Tu0Z3bw" name="P (plasma&lt;-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
+                <ValueOrigin id="49" source="Other" method="Assumption" description="Assumption: very fast exchange" />
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="134" />
+              </Parameter>
+              <Parameter id="F-bSO_souUuuDeOS5U_1Kw" name="Partition coefficient (interstitial/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" isDefault="1">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="148" />
+              </Parameter>
+            </Children>
+          </Container>
+          <Parameter id="81vc5OVID0K04ojOT3Q45g" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" isDefault="1" displayUnit="cm²">
             <Tags>
-              <Tag value="Neighborhood: Plasma / BloodCells" />
+              <Tag value="Neighborhood: Plasma / Interstitial" />
               <Tag value="Small intestine  neighborhood" />
             </Tags>
-            <Info min="0" flag="122" seq="23" ref="0" bb="32" group="104" />
+            <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+            <Info min="0" flag="122" seq="20" ref="0" bb="32" group="106" />
           </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="cYOV60Zvc0WqxijuhZVydA" name="LowerJejunum_int_LowerJejunum_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="5nN5NiM1M0K5ZU2nRPNl_Q" secondNeighbor="7dlPgIDV3kmO0AMYM-CWrQ">
+      <NeighborhoodBuilder id="qoPK7igv40ekPDbxYEsExg" name="UpperIleum_int_UpperIleum_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="3bFJZwHpsEmLwakaWGA6bA" secondNeighbor="shLM7VZLMEWIWyy3ZU-Wlw">
         <Tags>
           <Tag value="Neighborhood: Interstitial / Intracellular" />
           <Tag value="Small intestine  neighborhood" />
         </Tags>
         <Children>
-          <Container id="_Z52c1z8sEq1BMtgWKlIpg" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="sevEEsmnk0GOEyoNf26c2g" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="aunz-U9AhUizk5Zdg6TEGA" name="P (interstitial-&gt;intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_int_cell_Mucosa" isDefault="1" displayUnit="cm/min">
+              <Parameter id="hcayv8nsjkeoZdcJMzyCjg" name="P (interstitial-&gt;intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_int_cell_Mucosa" isDefault="1" displayUnit="cm/min">
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="135" />
               </Parameter>
-              <Parameter id="A_YwfEWmR0iNP_PUvDKCow" name="P (intracellular-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_cell_int_Mucosa" isDefault="1" displayUnit="cm/min">
+              <Parameter id="hxJItl4D9UekK7kVNgJpFw" name="P (intracellular-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_cell_int_Mucosa" isDefault="1" displayUnit="cm/min">
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="133" />
               </Parameter>
-              <Parameter id="ljIbpul000mczBXfASJ9bQ" name="P*SA interstitial -&gt; intracellular" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" isDefault="1" displayUnit="l/min">
+              <Parameter id="6IJXYO5U1kGQIZrpsB1hww" name="P*SA interstitial -&gt; intracellular" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" isDefault="1" displayUnit="l/min">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="8Or2HhGoV0e2tlB6TnRYTg" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
+              <Parameter id="wYwAkpfl0ECqSUeLM46efA" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="Y4W4HzThDEWQ62I3d9v4Ew" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
+              <Parameter id="ParR59kOWUW7OnY8PXnh8A" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="EDD90oGhfku51c82kigvKQ" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
+              <Parameter id="Mk305DbOq0OO8HRqKEYAvg" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="be8L8YH2ZUuyiE9j075JtA" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
-              </Parameter>
-              <Parameter id="C11vgOtoNkeU1eAZAyXLiw" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
+              <Parameter id="zioAzsTOzEi9t2OjfnJYfQ" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="147" />
               </Parameter>
+              <Parameter id="32DVDuwolk-IAOAVCDuiTA" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+              </Parameter>
             </Children>
           </Container>
-          <Parameter id="ljtMEMON50-LxmemSEscHg" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mucosa_lje" isDefault="1" displayUnit="cm²">
+          <Parameter id="4Hc1ZOIDKE-GwPLP94PDYQ" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mucosa_uil" isDefault="1" displayUnit="cm²">
             <Tags>
               <Tag value="Neighborhood: Interstitial / Intracellular" />
               <Tag value="Small intestine  neighborhood" />
             </Tags>
-            <Info min="0" flag="122" seq="20" ref="0" bb="32" group="105" />
+            <Info min="0" flag="122" seq="21" ref="0" bb="32" group="105" />
           </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="J5_GEPba50etNTlaoXe2tA" name="UpperIleum_int_UpperIleum_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="nq1wRgZMikC94IeNXWIr0A" secondNeighbor="nQCFgAfCi0WyyeCINOyruw">
+      <NeighborhoodBuilder id="7Z0kQFofgUCtiealHSjKqg" name="UpperIleum_pls_UpperIleum_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="ZzglrFxN2USNK0EBKHAKHw" secondNeighbor="A-W-9HQaxU2NdeD01TJ9vw">
         <Tags>
-          <Tag value="Neighborhood: Interstitial / Intracellular" />
+          <Tag value="Neighborhood: Plasma / BloodCells" />
           <Tag value="Small intestine  neighborhood" />
         </Tags>
         <Children>
-          <Container id="WGVJ0scob0GJAznVoy7zzw" name="MoleculeProperties" mode="Logical" containerType="Other">
-            <Children>
-              <Parameter id="znk4g-kEq0OkBdUDmIwtKQ" name="P*SA interstitial -&gt; intracellular" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" isDefault="1" displayUnit="l/min">
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
-              </Parameter>
-              <Parameter id="QjYfKJHNAU633xYmOtpfWw" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
-              </Parameter>
-              <Parameter id="fWqsTB6huke2H4UZsYum2g" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
-              </Parameter>
-              <Parameter id="j4G71CK7ckCM3F5HhtkweQ" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
-              </Parameter>
-              <Parameter id="zUjI0WPy0kqdwIKM7B3VxA" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="147" />
-              </Parameter>
-              <Parameter id="EJA_6aJGh02Rajt92ysBsQ" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
-              </Parameter>
-              <Parameter id="_pmgmWR-vEGQ8gxV9B0gbQ" name="P (interstitial-&gt;intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_int_cell_Mucosa" isDefault="1" displayUnit="cm/min">
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="135" />
-              </Parameter>
-              <Parameter id="6RyfVe4f7Uuk4LnSpk3Jmg" name="P (intracellular-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_cell_int_Mucosa" isDefault="1" displayUnit="cm/min">
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="133" />
-              </Parameter>
-            </Children>
-          </Container>
-          <Parameter id="5xqyHvZjFEWkh8Mqj3qlRA" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mucosa_uil" isDefault="1" displayUnit="cm²">
+          <Container id="_39nj963QkWNSbxo40F96Q" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Parameter id="no6XiF09BEe2fHdY4XfUvQ" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" isDefault="1" displayUnit="cm²">
             <Tags>
-              <Tag value="Neighborhood: Interstitial / Intracellular" />
+              <Tag value="Neighborhood: Plasma / BloodCells" />
               <Tag value="Small intestine  neighborhood" />
             </Tags>
-            <Info min="0" flag="122" seq="21" ref="0" bb="32" group="105" />
+            <Info min="0" flag="122" seq="24" ref="0" bb="32" group="104" />
           </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="HvMbsTC52U6wNYn2W3_Yvg" name="UpperIleum_pls_UpperIleum_int" mode="Logical" containerType="Neighborhood" firstNeighbor="8Ac8jM2ASUOjvqHKHA7z0Q" secondNeighbor="nq1wRgZMikC94IeNXWIr0A">
+      <NeighborhoodBuilder id="gjAywpleoEK4763pqHi99Q" name="UpperIleum_pls_UpperIleum_int" mode="Logical" containerType="Neighborhood" firstNeighbor="ZzglrFxN2USNK0EBKHAKHw" secondNeighbor="3bFJZwHpsEmLwakaWGA6bA">
         <Tags>
           <Tag value="Neighborhood: Plasma / Interstitial" />
           <Tag value="Small intestine  neighborhood" />
         </Tags>
         <Children>
-          <Container id="9zjO9-HtW0Wjs5l4uKSjFQ" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="uGgYwMxB4Ue87r-jfZIRbA" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="W3LElM2srE6aloJK3Ldkxg" name="P (plasma&lt;-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
-                <ValueOrigin id="49" method="Assumption" description="TODO: Default: very fast exchange" />
+              <Parameter id="MoE0fZnA6EmZngtntQbq5A" name="P (plasma&lt;-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
+                <ValueOrigin id="49" source="Other" method="Assumption" description="Assumption: very fast exchange" />
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="134" />
               </Parameter>
-              <Parameter id="eqlYGYZ39UWWA6yogq-zCQ" name="Partition coefficient (interstitial/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" isDefault="1">
+              <Parameter id="EfYuwqQb0Ui0GlsYL4uPtQ" name="Partition coefficient (interstitial/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" isDefault="1">
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="148" />
               </Parameter>
             </Children>
           </Container>
-          <Parameter id="0cwiqPoHXk2FWFSx2EBfUw" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" isDefault="1" displayUnit="cm²">
+          <Parameter id="FnUAN6cxhkiXLQwiYJB57A" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" isDefault="1" displayUnit="cm²">
             <Tags>
               <Tag value="Neighborhood: Plasma / Interstitial" />
               <Tag value="Small intestine  neighborhood" />
@@ -17184,57 +17273,41 @@
           </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="JmEqrgRxqkuuhReaFXiGnw" name="UpperIleum_pls_UpperIleum_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="8Ac8jM2ASUOjvqHKHA7z0Q" secondNeighbor="WMcsnhxGN0-dMioJaAzdBw">
-        <Tags>
-          <Tag value="Neighborhood: Plasma / BloodCells" />
-          <Tag value="Small intestine  neighborhood" />
-        </Tags>
-        <Children>
-          <Container id="5ciqRtaCX0CCW2M8-P8TUg" name="MoleculeProperties" mode="Logical" containerType="Other" />
-          <Parameter id="GOzY0gB_J0SPu1_ijFte3A" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" isDefault="1" displayUnit="cm²">
-            <Tags>
-              <Tag value="Neighborhood: Plasma / BloodCells" />
-              <Tag value="Small intestine  neighborhood" />
-            </Tags>
-            <Info min="0" flag="122" seq="24" ref="0" bb="32" group="104" />
-          </Parameter>
-        </Children>
-      </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="O09OBdHcKkC1K2JMRICeOg" name="LowerIleum_int_LowerIleum_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="wLhuhUiVaU6hMjW9YCcQkg" secondNeighbor="4DN3tqIxrEi2lucD2dTPCg">
+      <NeighborhoodBuilder id="nqHkY_nHZkCH-w7D1vNRWQ" name="LowerIleum_int_LowerIleum_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="4oq7UP86KUyjpoaRtRwk_A" secondNeighbor="jIkP3QhTpkaaJF858jl37g">
         <Tags>
           <Tag value="Neighborhood: Interstitial / Intracellular" />
           <Tag value="Small intestine  neighborhood" />
         </Tags>
         <Children>
-          <Container id="PUt7J-pnlUqnnd7p_szgdg" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="DSyfFPbkkEOIM4sojwhepg" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="exCnLm_AGk-Z9b1clJfwDg" name="P (interstitial-&gt;intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_int_cell_Mucosa" isDefault="1" displayUnit="cm/min">
+              <Parameter id="TJVTMHd3h066UTlW3c0Kfg" name="P (interstitial-&gt;intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_int_cell_Mucosa" isDefault="1" displayUnit="cm/min">
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="135" />
               </Parameter>
-              <Parameter id="FpE7rZwUk0qgseuqqqciAw" name="P (intracellular-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_cell_int_Mucosa" isDefault="1" displayUnit="cm/min">
+              <Parameter id="nS2m09VG60GW5XknAsd3BQ" name="P (intracellular-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_cell_int_Mucosa" isDefault="1" displayUnit="cm/min">
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="133" />
               </Parameter>
-              <Parameter id="8XDOPkiAGECfVTX_1-5dVw" name="P*SA interstitial -&gt; intracellular" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" isDefault="1" displayUnit="l/min">
+              <Parameter id="Q-Fq2ZR4_kKYYyaYEwh05Q" name="P*SA interstitial -&gt; intracellular" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" isDefault="1" displayUnit="l/min">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="Xv_-Zr7-2Uay6a4NaZxY_Q" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
+              <Parameter id="H6rV7LZMaU64-AAaONJtSw" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="cdUMXqWxV0C3SOrFGXchHA" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
-              </Parameter>
-              <Parameter id="TtqQdTONA0yVrw_6hOSxTg" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="147" />
-              </Parameter>
-              <Parameter id="9Kd-VGQwh0iU99UTfFMRjA" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
+              <Parameter id="5Sp3u39R0k272k_Z33Ht4Q" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="4Goir3zC9EO-Z9dHaVLg-g" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
+              <Parameter id="j8YCJL0npEe8HxLOkEEw8Q" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
+              <Parameter id="bx7uhi95wUKFiePNskcQkg" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="147" />
+              </Parameter>
+              <Parameter id="EBWAr8dWI0e7z9AkubM6TQ" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+              </Parameter>
             </Children>
           </Container>
-          <Parameter id="1rauCTmBskKT8pwFC8h86g" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mucosa_lil" isDefault="1" displayUnit="cm²">
+          <Parameter id="I2Emw2TB80a7i92IO-Dm6A" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mucosa_lil" isDefault="1" displayUnit="cm²">
             <Tags>
               <Tag value="Neighborhood: Interstitial / Intracellular" />
               <Tag value="Small intestine  neighborhood" />
@@ -17243,14 +17316,14 @@
           </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="FVJQIauBgk-Y4lHQi08dQA" name="LowerIleum_pls_LowerIleum_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="E7GcOFYu-UOF39Lu9dz1iw" secondNeighbor="f9sONmhHJ065miNP8o2zyw">
+      <NeighborhoodBuilder id="ugAJqlmh30et5culcESEtw" name="LowerIleum_pls_LowerIleum_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="zc7BjQ5jIkCNKX-V89xf8w" secondNeighbor="f_JTFfr9tEWHRt0TeebnGw">
         <Tags>
           <Tag value="Neighborhood: Plasma / BloodCells" />
           <Tag value="Small intestine  neighborhood" />
         </Tags>
         <Children>
-          <Container id="Ff3hFB2zyEm4M4JisJdJgQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
-          <Parameter id="RwNKh2H21kuLnQ6MNvhkyg" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" isDefault="1" displayUnit="cm²">
+          <Container id="y2xPxA3pl0200mYD8t3MYw" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Parameter id="cf1mPTeCwkGcE-sSBzbU-w" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" isDefault="1" displayUnit="cm²">
             <Tags>
               <Tag value="Neighborhood: Plasma / BloodCells" />
               <Tag value="Small intestine  neighborhood" />
@@ -17259,24 +17332,24 @@
           </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="KvmuBYRUG06ZntD1176i_g" name="LowerIleum_pls_LowerIleum_int" mode="Logical" containerType="Neighborhood" firstNeighbor="E7GcOFYu-UOF39Lu9dz1iw" secondNeighbor="wLhuhUiVaU6hMjW9YCcQkg">
+      <NeighborhoodBuilder id="p06LrV8YO0yri_fmZYtv5A" name="LowerIleum_pls_LowerIleum_int" mode="Logical" containerType="Neighborhood" firstNeighbor="zc7BjQ5jIkCNKX-V89xf8w" secondNeighbor="4oq7UP86KUyjpoaRtRwk_A">
         <Tags>
           <Tag value="Neighborhood: Plasma / Interstitial" />
           <Tag value="Small intestine  neighborhood" />
         </Tags>
         <Children>
-          <Container id="qQJrCz9sckmLDPEstum0wg" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="CoCXJfqTykm9T8VBliac5g" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="c-PAAq9JvECXJz3WkEw1ug" name="Partition coefficient (interstitial/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" isDefault="1">
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="148" />
-              </Parameter>
-              <Parameter id="j556nIMSDUeue2J6JImKPA" name="P (plasma&lt;-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
-                <ValueOrigin id="49" method="Assumption" description="TODO: Default: very fast exchange" />
+              <Parameter id="RvIblt2CqESSEZKVmsIbPw" name="P (plasma&lt;-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
+                <ValueOrigin id="49" source="Other" method="Assumption" description="Assumption: very fast exchange" />
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="134" />
               </Parameter>
+              <Parameter id="7s19qB8_MEqQeApEheIr5A" name="Partition coefficient (interstitial/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" isDefault="1">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="148" />
+              </Parameter>
             </Children>
           </Container>
-          <Parameter id="3rVy81ydHEi5pdg9qlD4Aw" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" isDefault="1" displayUnit="cm²">
+          <Parameter id="r8mnVHkwdUOqF2UXkOoUIw" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" isDefault="1" displayUnit="cm²">
             <Tags>
               <Tag value="Neighborhood: Plasma / Interstitial" />
               <Tag value="Small intestine  neighborhood" />
@@ -17286,41 +17359,41 @@
           </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="zFrluKqeiEizqXiMa26GLQ" name="Caecum_int_Caecum_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="beNTDbQolEqO-97pd3G3og" secondNeighbor="Si0F6PmVv0qRnmm7cbWb5A">
+      <NeighborhoodBuilder id="6Du6XL9O1kGF9w6ErwotWw" name="Caecum_int_Caecum_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="xBafoBV-d0yCjOUqux2Enw" secondNeighbor="9T8VbJMx3kaUZwobqt8v9w">
         <Tags>
           <Tag value="Large intestine  neighborhood" />
           <Tag value="Neighborhood: Interstitial / Intracellular" />
         </Tags>
         <Children>
-          <Container id="6S6BP89ecUiCkjO9V5-iZw" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="YV_jerNToEqYBsQPPxYKUw" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="KW8Db1eeGkaz0Xdayfv7aA" name="P (interstitial-&gt;intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_int_cell_Mucosa" isDefault="1" displayUnit="cm/min">
+              <Parameter id="lhEYyqQadUuMi-iFGzILqg" name="P (interstitial-&gt;intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_int_cell_Mucosa" isDefault="1" displayUnit="cm/min">
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="135" />
               </Parameter>
-              <Parameter id="vlY38gk2k0iof1csawrldw" name="P (intracellular-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_cell_int_Mucosa" isDefault="1" displayUnit="cm/min">
+              <Parameter id="Z-VjQkcNcEGCSIizcD0bKw" name="P (intracellular-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_cell_int_Mucosa" isDefault="1" displayUnit="cm/min">
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="133" />
               </Parameter>
-              <Parameter id="wPFhyRBF2Ua8MFOvqtblPQ" name="P*SA interstitial -&gt; intracellular" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" isDefault="1" displayUnit="l/min">
+              <Parameter id="8ptKhewG8EG1xsnFRQFeag" name="P*SA interstitial -&gt; intracellular" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" isDefault="1" displayUnit="l/min">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="b5EbuHk8skqsvsK8zE0D0Q" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
+              <Parameter id="urrE_2P1f0OiU9KSiZ8NNg" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="ttCNlIC1REKRQz4aoYZEvw" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
+              <Parameter id="hPGo0SDzV0eMg3vSwB-K9w" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="0X_v_j295EukgXigLb_uTA" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
+              <Parameter id="Y9hNnzEFPU6j9XXpjQrF3g" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="4FJc2SdNc0uLSA5q_agdLw" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
+              <Parameter id="7pTEVPy7Q0ikAQCOsQ3gGg" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="147" />
               </Parameter>
-              <Parameter id="TIjHXZSHjUal7TtOOD_3FA" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
+              <Parameter id="xvhSknGjn0aPXtBfZvZQaA" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
               </Parameter>
             </Children>
           </Container>
-          <Parameter id="rsq92dLkJUi_GK_S1F9WyA" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mucosa_cae" isDefault="1" displayUnit="cm²">
+          <Parameter id="mYpqi7F7C0Czx3B020M5ZQ" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mucosa_cae" isDefault="1" displayUnit="cm²">
             <Tags>
               <Tag value="Large intestine  neighborhood" />
               <Tag value="Neighborhood: Interstitial / Intracellular" />
@@ -17329,14 +17402,14 @@
           </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="qfYoG7jn4kOm-ZQePg-2wg" name="Caecum_pls_Caecum_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="LzJaekJVEUe4P9I9KnDGkQ" secondNeighbor="TZOfiNQfs0GwnASXrHgFkw">
+      <NeighborhoodBuilder id="5xSaEvjXSkOWYupHUOZ7aQ" name="Caecum_pls_Caecum_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="ZxVt3miuQEiGCJszptmYuQ" secondNeighbor="NugBHVuOHEervTrkBVs4wg">
         <Tags>
           <Tag value="Large intestine  neighborhood" />
           <Tag value="Neighborhood: Plasma / BloodCells" />
         </Tags>
         <Children>
-          <Container id="YT67_4CkpUu1CDlFQ8kuoA" name="MoleculeProperties" mode="Logical" containerType="Other" />
-          <Parameter id="tyyp2KOLE0eOjjD4e1pUUQ" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" isDefault="1" displayUnit="cm²">
+          <Container id="UvIfw8fL8UOxGvAnGuJzpQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Parameter id="JEDntHmhQkWJcgrzynQzEA" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" isDefault="1" displayUnit="cm²">
             <Tags>
               <Tag value="Large intestine  neighborhood" />
               <Tag value="Neighborhood: Plasma / BloodCells" />
@@ -17345,24 +17418,24 @@
           </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="LjOaIzjxP0mXgVBbpP952Q" name="Caecum_pls_Caecum_int" mode="Logical" containerType="Neighborhood" firstNeighbor="LzJaekJVEUe4P9I9KnDGkQ" secondNeighbor="beNTDbQolEqO-97pd3G3og">
+      <NeighborhoodBuilder id="WPXltFMk80iO1Byq2S6GDA" name="Caecum_pls_Caecum_int" mode="Logical" containerType="Neighborhood" firstNeighbor="ZxVt3miuQEiGCJszptmYuQ" secondNeighbor="xBafoBV-d0yCjOUqux2Enw">
         <Tags>
           <Tag value="Large intestine  neighborhood" />
           <Tag value="Neighborhood: Plasma / Interstitial" />
         </Tags>
         <Children>
-          <Container id="2lqQlcTyYUGNLdzFX0uO2Q" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="1azdfRrqcUGK5IvJe2fsFg" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="qs_TjyZz10a2HyFAq6iSoA" name="P (plasma&lt;-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
-                <ValueOrigin id="49" method="Assumption" description="TODO: Default: very fast exchange" />
+              <Parameter id="r7-xhXRTrEWMnm8uaMiHqg" name="P (plasma&lt;-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
+                <ValueOrigin id="49" source="Other" method="Assumption" description="Assumption: very fast exchange" />
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="134" />
               </Parameter>
-              <Parameter id="FCp2rlXeZU6TXzEi9HDi_g" name="Partition coefficient (interstitial/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" isDefault="1">
+              <Parameter id="NkGi-QLX10SgiQsyqdsC8Q" name="Partition coefficient (interstitial/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" isDefault="1">
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="148" />
               </Parameter>
             </Children>
           </Container>
-          <Parameter id="AVe7x07DAUyAa52nmh5lLw" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" isDefault="1" displayUnit="cm²">
+          <Parameter id="NKqlVwf5q0aeSpS6LktDgw" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" isDefault="1" displayUnit="cm²">
             <Tags>
               <Tag value="Large intestine  neighborhood" />
               <Tag value="Neighborhood: Plasma / Interstitial" />
@@ -17372,41 +17445,41 @@
           </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="viTzulst10mvv2uBmEzQaQ" name="ColonAscendens_int_ColonAscendens_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="_RrXg5iGA0abZtIK9opnGQ" secondNeighbor="xgXczYdZrE692wGtlg0fgA">
+      <NeighborhoodBuilder id="mHKCQCjVQ0uz4el1LaWkhQ" name="ColonAscendens_int_ColonAscendens_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="S9HSD1S7I0S6TZw_WfUqFg" secondNeighbor="WLbI5Rdu60Wk9X8eKNb3tg">
         <Tags>
           <Tag value="Large intestine  neighborhood" />
           <Tag value="Neighborhood: Interstitial / Intracellular" />
         </Tags>
         <Children>
-          <Container id="lqqtS6-R_EGRXOCHw4Wccg" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="voJxHnrZzkqE38ZsmOs6PQ" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="0ZyIdL8QSE6RyEEkdjyEKQ" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
-              </Parameter>
-              <Parameter id="-kIOGhFWzEGOVd9SVrk6AA" name="P (interstitial-&gt;intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_int_cell_Mucosa" isDefault="1" displayUnit="cm/min">
+              <Parameter id="0VLRzVkQ9UyaGHzIMvjQcQ" name="P (interstitial-&gt;intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_int_cell_Mucosa" isDefault="1" displayUnit="cm/min">
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="135" />
               </Parameter>
-              <Parameter id="qaNu4TRVLkWqSdMfCkCQKQ" name="P*SA interstitial -&gt; intracellular" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" isDefault="1" displayUnit="l/min">
+              <Parameter id="KuyxUJey30Oj05zYpV_RfQ" name="P (intracellular-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_cell_int_Mucosa" isDefault="1" displayUnit="cm/min">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="133" />
+              </Parameter>
+              <Parameter id="ckjR8rjxHUuxjwoEb86EDQ" name="P*SA interstitial -&gt; intracellular" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" isDefault="1" displayUnit="l/min">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="oWPK0LI2QUGg8SkxYqVIvg" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
+              <Parameter id="zjRiUf-C6UGMU_3_TyWJig" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="dtUsmoTt3Ui5kW7bnw65kQ" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
+              <Parameter id="kCYMWKwoAUyJdfKWe0RmKw" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="Pb1Ajk3XSk2bVtw-Taamrg" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
+              <Parameter id="-EEXyB8AX0Gy0BNUSwwTGQ" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="KBy1nRZSXE-PkS2Xt05uuw" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="147" />
               </Parameter>
-              <Parameter id="ZZBx8uFq0E-WIEnZrp9q6w" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
+              <Parameter id="vVfrxebHTEujCN50EQbmwA" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
               </Parameter>
-              <Parameter id="CXiEKTmetkWd7cL2KWBEhg" name="P (intracellular-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_cell_int_Mucosa" isDefault="1" displayUnit="cm/min">
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="133" />
-              </Parameter>
             </Children>
           </Container>
-          <Parameter id="jnMEH45SjUGfNPVzEn8_Aw" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mucosa_colasc" isDefault="1" displayUnit="cm²">
+          <Parameter id="BIPF1CgaqEyA4FRiolpbcQ" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mucosa_colasc" isDefault="1" displayUnit="cm²">
             <Tags>
               <Tag value="Large intestine  neighborhood" />
               <Tag value="Neighborhood: Interstitial / Intracellular" />
@@ -17415,24 +17488,40 @@
           </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="XIq-z0m0xkCCpOnl_jmtTw" name="ColonAscendens_pls_ColonAscendens_int" mode="Logical" containerType="Neighborhood" firstNeighbor="PlqyZ7UZA0CFE5wh4HT-4A" secondNeighbor="_RrXg5iGA0abZtIK9opnGQ">
+      <NeighborhoodBuilder id="OJP1bah8LkysTPkbWtYjpg" name="ColonAscendens_pls_ColonAscendens_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="Enan29lQuku7kissDlHImQ" secondNeighbor="Hoo2O0GaRU2870Bnck5hxw">
+        <Tags>
+          <Tag value="Large intestine  neighborhood" />
+          <Tag value="Neighborhood: Plasma / BloodCells" />
+        </Tags>
+        <Children>
+          <Container id="bNRrtXcdq0W5ETLXhVk8sg" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Parameter id="1cml7OstZ0WshGe0BWfjKw" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" isDefault="1" displayUnit="cm²">
+            <Tags>
+              <Tag value="Large intestine  neighborhood" />
+              <Tag value="Neighborhood: Plasma / BloodCells" />
+            </Tags>
+            <Info min="0" flag="122" seq="27" ref="0" bb="32" group="104" />
+          </Parameter>
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="obioLrpu2Uy-S-_aP0pIIA" name="ColonAscendens_pls_ColonAscendens_int" mode="Logical" containerType="Neighborhood" firstNeighbor="Enan29lQuku7kissDlHImQ" secondNeighbor="S9HSD1S7I0S6TZw_WfUqFg">
         <Tags>
           <Tag value="Large intestine  neighborhood" />
           <Tag value="Neighborhood: Plasma / Interstitial" />
         </Tags>
         <Children>
-          <Container id="-hbvHoFkHU2_KIWqLFU01w" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="ln0xKpOQrEqQOuW_1F_-vQ" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="fzg8DN_w40yf41iSev2D5g" name="Partition coefficient (interstitial/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" isDefault="1">
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="148" />
-              </Parameter>
-              <Parameter id="jI2Mo5KzQ0OfVJWs6s-SXg" name="P (plasma&lt;-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
-                <ValueOrigin id="49" method="Assumption" description="TODO: Default: very fast exchange" />
+              <Parameter id="1rNVN0PlFESYkRS4DIc9Bw" name="P (plasma&lt;-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
+                <ValueOrigin id="49" source="Other" method="Assumption" description="Assumption: very fast exchange" />
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="134" />
               </Parameter>
+              <Parameter id="bk5AWiY7dkyXWF7oyg_QgA" name="Partition coefficient (interstitial/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" isDefault="1">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="148" />
+              </Parameter>
             </Children>
           </Container>
-          <Parameter id="lJU7wybauEGQwavWJjSIHw" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" isDefault="1" displayUnit="cm²">
+          <Parameter id="ebyTbvV4jU-nC4MyetpP0w" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" isDefault="1" displayUnit="cm²">
             <Tags>
               <Tag value="Large intestine  neighborhood" />
               <Tag value="Neighborhood: Plasma / Interstitial" />
@@ -17442,30 +17531,57 @@
           </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="vQLdRfvKGUuQoZLrNviAyA" name="ColonAscendens_pls_ColonAscendens_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="PlqyZ7UZA0CFE5wh4HT-4A" secondNeighbor="9KAYzyIOgUm0aPJQU3yU1A">
+      <NeighborhoodBuilder id="1-Yyv4BzGE6NEYXkOEjPwA" name="ColonTransversum_int_ColonTransversum_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="F_A4648Qg0SRyArlhhx5Cg" secondNeighbor="1UgZYU8R5UWKEifrALKt2w">
         <Tags>
           <Tag value="Large intestine  neighborhood" />
-          <Tag value="Neighborhood: Plasma / BloodCells" />
+          <Tag value="Neighborhood: Interstitial / Intracellular" />
         </Tags>
         <Children>
-          <Container id="T8xkSS--RkKC8CjgC5tw4w" name="MoleculeProperties" mode="Logical" containerType="Other" />
-          <Parameter id="OJzNxBJrUkW_HEAgLhl_9g" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" isDefault="1" displayUnit="cm²">
+          <Container id="Q9WeoRTI-km_OYpqJCKj9Q" name="MoleculeProperties" mode="Logical" containerType="Other">
+            <Children>
+              <Parameter id="HTghY3lqjUKuPEYugaeDvA" name="P (interstitial-&gt;intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_int_cell_Mucosa" isDefault="1" displayUnit="cm/min">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="135" />
+              </Parameter>
+              <Parameter id="wbP8n635OU-GT6I4qMNylQ" name="P (intracellular-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_cell_int_Mucosa" isDefault="1" displayUnit="cm/min">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="133" />
+              </Parameter>
+              <Parameter id="Wbp6rjzRn0WK2uDNWiwZzA" name="P*SA interstitial -&gt; intracellular" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" isDefault="1" displayUnit="l/min">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="TkS73jZcXUeVEA8JxCA3MA" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="dTzbf3Qzj0auEFh5MvN3fA" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="wlA15eONaEervnC6bsXRFQ" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="lA2sTVfF4UmJNq6ZnoS1VQ" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="147" />
+              </Parameter>
+              <Parameter id="7Ibyp7KDjUq2A8C8L9kNKg" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+              </Parameter>
+            </Children>
+          </Container>
+          <Parameter id="er0FqeH5gU2SPut6-PAzDw" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mucosa_coltrans" isDefault="1" displayUnit="cm²">
             <Tags>
               <Tag value="Large intestine  neighborhood" />
-              <Tag value="Neighborhood: Plasma / BloodCells" />
+              <Tag value="Neighborhood: Interstitial / Intracellular" />
             </Tags>
-            <Info min="0" flag="122" seq="27" ref="0" bb="32" group="104" />
+            <Info min="0" flag="122" seq="25" ref="0" bb="32" group="105" />
           </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="wXce1Ien6Eq7DC4exEWf_Q" name="ColonTransversum_pls_ColonTransversum_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="bmNZtt8nFEaRbFLVSheTLQ" secondNeighbor="XD1QQa45SEaBqQBgPHhV4g">
+      <NeighborhoodBuilder id="8-uqP9xmH0CBNy0FfcBYkA" name="ColonTransversum_pls_ColonTransversum_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="YYnhx2F-NU2lWPQmgq2Ulg" secondNeighbor="osnPctKJG0u6adLxRN6NBg">
         <Tags>
           <Tag value="Large intestine  neighborhood" />
           <Tag value="Neighborhood: Plasma / BloodCells" />
         </Tags>
         <Children>
-          <Container id="bgkkU3fVCkK0LVuJF0_KYQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
-          <Parameter id="p14ySve9xUiXZIzHohdvJQ" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" isDefault="1" displayUnit="cm²">
+          <Container id="Ptr04O3yXkWKzYPeg1pJ2Q" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Parameter id="sN5Cm2O7p0q3vjsiQz5uFA" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" isDefault="1" displayUnit="cm²">
             <Tags>
               <Tag value="Large intestine  neighborhood" />
               <Tag value="Neighborhood: Plasma / BloodCells" />
@@ -17474,24 +17590,24 @@
           </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="Ee8KWZuZTUChRgO7uPyzvQ" name="ColonTransversum_pls_ColonTransversum_int" mode="Logical" containerType="Neighborhood" firstNeighbor="bmNZtt8nFEaRbFLVSheTLQ" secondNeighbor="tKhAurmDF0aooV-Gkc4uiQ">
+      <NeighborhoodBuilder id="xMPf1qBCt0Ctnq_T4kzVMA" name="ColonTransversum_pls_ColonTransversum_int" mode="Logical" containerType="Neighborhood" firstNeighbor="YYnhx2F-NU2lWPQmgq2Ulg" secondNeighbor="F_A4648Qg0SRyArlhhx5Cg">
         <Tags>
           <Tag value="Large intestine  neighborhood" />
           <Tag value="Neighborhood: Plasma / Interstitial" />
         </Tags>
         <Children>
-          <Container id="mkt7JbFuYkWQXKRyOGtFIA" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="zepp6zxDOUSPK-4PBh_96g" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="I6CxDdrQJEmziTDuOrb4-w" name="P (plasma&lt;-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
-                <ValueOrigin id="49" method="Assumption" description="TODO: Default: very fast exchange" />
+              <Parameter id="Im9_iv7qV0ykkFeX4eTMkw" name="P (plasma&lt;-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
+                <ValueOrigin id="49" source="Other" method="Assumption" description="Assumption: very fast exchange" />
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="134" />
               </Parameter>
-              <Parameter id="Ok3Lhk-AbkS0m4wt7-3A9w" name="Partition coefficient (interstitial/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" isDefault="1">
+              <Parameter id="lTE6JxfGEkCNIQBKm5FAYQ" name="Partition coefficient (interstitial/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" isDefault="1">
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="148" />
               </Parameter>
             </Children>
           </Container>
-          <Parameter id="UIVulxgn9U6okJh9IBjYRg" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" isDefault="1" displayUnit="cm²">
+          <Parameter id="eyyA5banfk2KKYC3GiAfyg" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" isDefault="1" displayUnit="cm²">
             <Tags>
               <Tag value="Large intestine  neighborhood" />
               <Tag value="Neighborhood: Plasma / Interstitial" />
@@ -17501,67 +17617,83 @@
           </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="7T1HKN4I2EuHJ2RSzbLo7w" name="ColonTransversum_int_ColonTransversum_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="tKhAurmDF0aooV-Gkc4uiQ" secondNeighbor="Wr481BzF70KwAYQOaEn_ag">
+      <NeighborhoodBuilder id="ln__jQMJLUekEzTccxScGA" name="ColonDescendens_int_ColonDescendens_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="VytvFP3rgkOt4KuoYbrDmQ" secondNeighbor="lB3zaDNmVkWiBvM88nUHOw">
         <Tags>
           <Tag value="Large intestine  neighborhood" />
           <Tag value="Neighborhood: Interstitial / Intracellular" />
         </Tags>
         <Children>
-          <Container id="mAlbnMA-J0aDwbuYVwPF2g" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="1G-m9ML2t0KslXmKpJro1w" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="hoO2FiIZPkitIQcD5ag0Pw" name="P (interstitial-&gt;intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_int_cell_Mucosa" isDefault="1" displayUnit="cm/min">
+              <Parameter id="BMqLr0ipiUioLcttp6dPCw" name="P (interstitial-&gt;intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_int_cell_Mucosa" isDefault="1" displayUnit="cm/min">
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="135" />
               </Parameter>
-              <Parameter id="VsOXdZsraE292cLwQHabOQ" name="P (intracellular-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_cell_int_Mucosa" isDefault="1" displayUnit="cm/min">
+              <Parameter id="xkBx2VJ4tU2wJhSBOQ-WEw" name="P (intracellular-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_cell_int_Mucosa" isDefault="1" displayUnit="cm/min">
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="133" />
               </Parameter>
-              <Parameter id="hGy8CEFepUK4OK7QPhrVhQ" name="P*SA interstitial -&gt; intracellular" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" isDefault="1" displayUnit="l/min">
+              <Parameter id="__-qOaPjxkObhIeYtNWrTQ" name="P*SA interstitial -&gt; intracellular" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" isDefault="1" displayUnit="l/min">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="zYD4Q_t2C0SQVGt8DGfqWw" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
+              <Parameter id="C-CN-RI4R0uHQorIxAWppQ" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="EFd5kQhK8U6G6fWUv6-vIw" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="147" />
+              <Parameter id="ossC0_uXR0GTgDj2F0SN2A" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="7zduHGzzIE-15HRzVSYIpA" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
+              <Parameter id="5nKGe1X3skSxIRMx8dYNEw" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="sTn08Vi4e0yH5ZPNYr2hHw" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+              <Parameter id="YXjTPcPma0WvZgtWyPDCWw" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="147" />
               </Parameter>
-              <Parameter id="36x9YfN9aECKYAQ1Et3GpA" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+              <Parameter id="IhB98jynQUOosB4Xs13q-Q" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
               </Parameter>
             </Children>
           </Container>
-          <Parameter id="qJlno3vRM0-O_voDyZ_ryA" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mucosa_coltrans" isDefault="1" displayUnit="cm²">
+          <Parameter id="1b5cYuYDjk-uAl5zJdPayQ" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mucosa_coldesc" isDefault="1" displayUnit="cm²">
             <Tags>
               <Tag value="Large intestine  neighborhood" />
               <Tag value="Neighborhood: Interstitial / Intracellular" />
             </Tags>
-            <Info min="0" flag="122" seq="25" ref="0" bb="32" group="105" />
+            <Info min="0" flag="122" seq="26" ref="0" bb="32" group="105" />
+          </Parameter>
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="dnX6IAEv2kigmPUb3lGt9w" name="ColonDescendens_pls_ColonDescendens_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="7yM-io-zfEuH_h7HbN-j3Q" secondNeighbor="Cl9Z1Ct4BEipGzx35zr3hA">
+        <Tags>
+          <Tag value="Large intestine  neighborhood" />
+          <Tag value="Neighborhood: Plasma / BloodCells" />
+        </Tags>
+        <Children>
+          <Container id="hLzd2Aqv20agls_yE-MrxQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Parameter id="YtLnXSfN2EOknY5cAftX-Q" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" isDefault="1" displayUnit="cm²">
+            <Tags>
+              <Tag value="Large intestine  neighborhood" />
+              <Tag value="Neighborhood: Plasma / BloodCells" />
+            </Tags>
+            <Info min="0" flag="122" seq="29" ref="0" bb="32" group="104" />
           </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="x8TzZnzxpkmFoeespLWVkQ" name="ColonDescendens_pls_ColonDescendens_int" mode="Logical" containerType="Neighborhood" firstNeighbor="IUx7uFw2hEyGTiqkSDgZaQ" secondNeighbor="nnvbzvW5h0yCFsMRXX-tug">
+      <NeighborhoodBuilder id="OpSx0YJEBUmcgjmrzmUfHw" name="ColonDescendens_pls_ColonDescendens_int" mode="Logical" containerType="Neighborhood" firstNeighbor="7yM-io-zfEuH_h7HbN-j3Q" secondNeighbor="VytvFP3rgkOt4KuoYbrDmQ">
         <Tags>
           <Tag value="Large intestine  neighborhood" />
           <Tag value="Neighborhood: Plasma / Interstitial" />
         </Tags>
         <Children>
-          <Container id="ESJccUlVDE2Ve8qKVGhOAQ" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="VcGvwumfoUCfH-S1-gKxcg" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="71gGfKKKuEmrrwFBR_nmQg" name="P (plasma&lt;-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
-                <ValueOrigin id="49" method="Assumption" description="TODO: Default: very fast exchange" />
+              <Parameter id="cIFkQpGyJkOVVDYzHM5pSw" name="P (plasma&lt;-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
+                <ValueOrigin id="49" source="Other" method="Assumption" description="Assumption: very fast exchange" />
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="134" />
               </Parameter>
-              <Parameter id="WqwMzyRg0kq6hbRJH6_Mgg" name="Partition coefficient (interstitial/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" isDefault="1">
+              <Parameter id="7J8XCvb3HU28A_rDi3YsCg" name="Partition coefficient (interstitial/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" isDefault="1">
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="148" />
               </Parameter>
             </Children>
           </Container>
-          <Parameter id="qxkq2-DxuEaJyUel1hebuQ" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" isDefault="1" displayUnit="cm²">
+          <Parameter id="Fh0bEZ6bU020k48tWdkQRA" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" isDefault="1" displayUnit="cm²">
             <Tags>
               <Tag value="Large intestine  neighborhood" />
               <Tag value="Neighborhood: Plasma / Interstitial" />
@@ -17571,451 +17703,512 @@
           </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="EdD8oH6MvUGxrL0q1Kr_KQ" name="ColonDescendens_pls_ColonDescendens_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="IUx7uFw2hEyGTiqkSDgZaQ" secondNeighbor="XocTM5veBEGBOOmndILFgg">
-        <Tags>
-          <Tag value="Large intestine  neighborhood" />
-          <Tag value="Neighborhood: Plasma / BloodCells" />
-        </Tags>
-        <Children>
-          <Container id="efez84UbgkKn1aHw9JZU4Q" name="MoleculeProperties" mode="Logical" containerType="Other" />
-          <Parameter id="QGYHzDvdyEu-PxNyGdTYVQ" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" isDefault="1" displayUnit="cm²">
-            <Tags>
-              <Tag value="Large intestine  neighborhood" />
-              <Tag value="Neighborhood: Plasma / BloodCells" />
-            </Tags>
-            <Info min="0" flag="122" seq="29" ref="0" bb="32" group="104" />
-          </Parameter>
-        </Children>
-      </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="V5NkXp2Em0uK9Ru5hFpVoQ" name="ColonDescendens_int_ColonDescendens_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="nnvbzvW5h0yCFsMRXX-tug" secondNeighbor="iaAT-1dG0USXIQUM5EweVw">
+      <NeighborhoodBuilder id="jL2QSJ5ImE-YSmwQ361oqw" name="ColonSigmoid_int_ColonSigmoid_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="UQxGm737EEy5IT7mHMQoGQ" secondNeighbor="tN9zkiBQG0CU40pBquto3w">
         <Tags>
           <Tag value="Large intestine  neighborhood" />
           <Tag value="Neighborhood: Interstitial / Intracellular" />
         </Tags>
         <Children>
-          <Container id="rRw0Cr-sNkOoZp6ur8fqvw" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="ySh6ziGrbEW6V_FYy3YQ9Q" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="ZcE15PC62EiLoqLIoUfB7A" name="P (interstitial-&gt;intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_int_cell_Mucosa" isDefault="1" displayUnit="cm/min">
+              <Parameter id="yDQbMwJmJEadW2ojAC1Ugw" name="P (interstitial-&gt;intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_int_cell_Mucosa" isDefault="1" displayUnit="cm/min">
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="135" />
               </Parameter>
-              <Parameter id="a5boWFi6JE-ONKSdvlxSSg" name="P (intracellular-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_cell_int_Mucosa" isDefault="1" displayUnit="cm/min">
+              <Parameter id="7wFI6rkRE0mmUjOZdiMRUQ" name="P (intracellular-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_cell_int_Mucosa" isDefault="1" displayUnit="cm/min">
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="133" />
               </Parameter>
-              <Parameter id="Zc62EKd63kW6DLmhBiyoBw" name="P*SA interstitial -&gt; intracellular" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" isDefault="1" displayUnit="l/min">
+              <Parameter id="Gkxco0her0SHHCjss0j0WQ" name="P*SA interstitial -&gt; intracellular" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" isDefault="1" displayUnit="l/min">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="q7VGPCxJskaBfaJsNtfC9A" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
+              <Parameter id="ABPGiW9yoUufOcxW-Q4eRg" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="krH9okn22USB96SX8zjbCw" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
+              <Parameter id="5HBcgj3QOUaYoaafSZyJcQ" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="ZpzcuxdsN0ehn-PgccgPPg" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
+              <Parameter id="G3H8IZ0GMEK86qO2pH2efA" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="CSHiy7fAZUG22HUptAwmlg" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
+              <Parameter id="bON6agzoJkqP4rVO2vnooA" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="147" />
               </Parameter>
-              <Parameter id="5p3WtxdUdkWsyAPx7J80PA" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
+              <Parameter id="TMKrpZbg106LCLeiIekGoQ" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
               </Parameter>
             </Children>
           </Container>
-          <Parameter id="nZA4R-gnmkebqSugEmoB0g" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mucosa_coldesc" isDefault="1" displayUnit="cm²">
+          <Parameter id="qu_UQYI_J0K8G3kNAA-Xwg" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mucosa_colsigm" isDefault="1" displayUnit="cm²">
             <Tags>
               <Tag value="Large intestine  neighborhood" />
               <Tag value="Neighborhood: Interstitial / Intracellular" />
             </Tags>
-            <Info min="0" flag="122" seq="26" ref="0" bb="32" group="105" />
+            <Info min="0" flag="122" seq="27" ref="0" bb="32" group="105" />
           </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="XWy6g8iReUGzbdbMxe2p2Q" name="ColonSigmoid_int_ColonSigmoid_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="yv_YyAZA6kGkZtTW9kyhcw" secondNeighbor="-UolCvDsZkqBk6uvEQwkyg">
+      <NeighborhoodBuilder id="jTYJNOejKU-rCr4uxEojdw" name="ColonSigmoid_pls_ColonSigmoid_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="4yj_1inZg0u37EViZ_d2aw" secondNeighbor="Dj8oXl7e4EutUb0fHRRlag">
+        <Tags>
+          <Tag value="Large intestine  neighborhood" />
+          <Tag value="Neighborhood: Plasma / BloodCells" />
+        </Tags>
+        <Children>
+          <Container id="WawQr6k7-k-wEErb3DryAw" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Parameter id="OanCRGanvUi5tFzKTRIIwQ" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" isDefault="1" displayUnit="cm²">
+            <Tags>
+              <Tag value="Large intestine  neighborhood" />
+              <Tag value="Neighborhood: Plasma / BloodCells" />
+            </Tags>
+            <Info min="0" flag="122" seq="30" ref="0" bb="32" group="104" />
+          </Parameter>
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="0qqzeTKjPUq43ZnTRUZ1JA" name="ColonSigmoid_pls_ColonSigmoid_int" mode="Logical" containerType="Neighborhood" firstNeighbor="4yj_1inZg0u37EViZ_d2aw" secondNeighbor="UQxGm737EEy5IT7mHMQoGQ">
+        <Tags>
+          <Tag value="Large intestine  neighborhood" />
+          <Tag value="Neighborhood: Plasma / Interstitial" />
+        </Tags>
+        <Children>
+          <Container id="T09jz6tPp02-zkP3CGzB1g" name="MoleculeProperties" mode="Logical" containerType="Other">
+            <Children>
+              <Parameter id="I0tfi1s-okmJDd4zQsrgkw" name="P (plasma&lt;-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
+                <ValueOrigin id="49" source="Other" method="Assumption" description="Assumption: very fast exchange" />
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="134" />
+              </Parameter>
+              <Parameter id="Jsr32M6xJEeM8n26Nfu6SQ" name="Partition coefficient (interstitial/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" isDefault="1">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="148" />
+              </Parameter>
+            </Children>
+          </Container>
+          <Parameter id="pRDIRAzkCkaB50P3vs8wqw" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" isDefault="1" displayUnit="cm²">
+            <Tags>
+              <Tag value="Large intestine  neighborhood" />
+              <Tag value="Neighborhood: Plasma / Interstitial" />
+            </Tags>
+            <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+            <Info min="0" flag="122" seq="27" ref="0" bb="32" group="106" />
+          </Parameter>
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="0euZ8Z1SIUOadvz2TwrFlA" name="Rectum_int_Rectum_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="Yx0Z8ur6JU6CM5_rwqvx4g" secondNeighbor="iIAVNSjiW0S2nzttLSTPAw">
         <Tags>
           <Tag value="Large intestine  neighborhood" />
           <Tag value="Neighborhood: Interstitial / Intracellular" />
         </Tags>
         <Children>
-          <Container id="UFyJ6V-X3kqvlohUXXo8xw" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="jBwHh2QhXEa-Sn6VPm5RmA" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="319oj08yEE--7BL6At2MuA" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+              <Parameter id="WPrS-dRJ0UmWjF8Zo5qpig" name="P (interstitial-&gt;intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_int_cell_Mucosa" isDefault="1" displayUnit="cm/min">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="135" />
               </Parameter>
-              <Parameter id="Ok4pAjg0cUWnE-bYIWIz_w" name="P (intracellular-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_cell_int_Mucosa" isDefault="1" displayUnit="cm/min">
+              <Parameter id="VtRLbafgeUS6Uqpgxp2wYw" name="P (intracellular-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_cell_int_Mucosa" isDefault="1" displayUnit="cm/min">
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="133" />
               </Parameter>
-              <Parameter id="d8B6kima00uPYoTJdeVVnA" name="P*SA interstitial -&gt; intracellular" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" isDefault="1" displayUnit="l/min">
+              <Parameter id="wRxhGJq31UyEGdVnBrDOWg" name="P*SA interstitial -&gt; intracellular" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" isDefault="1" displayUnit="l/min">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="5bnXNLAeNkqu9FYw88hGzg" name="P (interstitial-&gt;intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_int_cell_Mucosa" isDefault="1" displayUnit="cm/min">
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="135" />
+              <Parameter id="EN8-1wOp0EmatfNPPD3omA" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="uz1QS1L54UGGa4t6CB8TQg" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
+              <Parameter id="uX1RWEYtd02vUuZ4uspJJA" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
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+              <Parameter id="JEFqI4KWSk2luvnGOotd3g" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
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+              <Parameter id="FIhpqJxtmEmWMRYe6uLK1A" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
                 <Info min="0" flag="122" seq="1" ref="0" bb="2" group="147" />
               </Parameter>
-              <Parameter id="5iez3xP7KUaaMmcw08qJbQ" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
+              <Parameter id="LNlO_pFUoESHYuSARLq1pA" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
               </Parameter>
             </Children>
           </Container>
-          <Parameter id="bDedxs6FzkGy9xngkax6AQ" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mucosa_colsigm" isDefault="1" displayUnit="cm²">
+          <Parameter id="Cj-VrWayAEKuD2WdyDaXZw" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mucosa_rect" isDefault="1" displayUnit="cm²">
             <Tags>
               <Tag value="Large intestine  neighborhood" />
               <Tag value="Neighborhood: Interstitial / Intracellular" />
             </Tags>
-            <Info min="0" flag="122" seq="27" ref="0" bb="32" group="105" />
+            <Info min="0" flag="122" seq="28" ref="0" bb="32" group="105" />
           </Parameter>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="b8lGmVj9mE2KMQdWs8hfxw" name="ColonSigmoid_pls_ColonSigmoid_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="OvLTrMh7lk6jo7evtaDYJg" secondNeighbor="saCFzb5mNkqDgp9lSJDPtQ">
+      <NeighborhoodBuilder id="xJbywqnvEU2Tq30SyOzD2g" name="Rectum_pls_Rectum_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="54DFX1N5kkGUNRfAo0xMkw" secondNeighbor="ab5YKqDQeEe4od70TEbWtg">
+        <Tags>
+          <Tag value="Large intestine  neighborhood" />
+          <Tag value="Neighborhood: Plasma / BloodCells" />
+        </Tags>
+        <Children>
+          <Container id="aLbvRE41mUiJzoJRaWD4iQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Parameter id="c8y9HvErg02RS7Cho_-wVw" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" isDefault="1" displayUnit="cm²">
+            <Tags>
+              <Tag value="Large intestine  neighborhood" />
+              <Tag value="Neighborhood: Plasma / BloodCells" />
+            </Tags>
+            <Info min="0" flag="122" seq="31" ref="0" bb="32" group="104" />
+          </Parameter>
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="0jUShr5He0WsOG_9ix3Pqw" name="Rectum_pls_Rectum_int" mode="Logical" containerType="Neighborhood" firstNeighbor="54DFX1N5kkGUNRfAo0xMkw" secondNeighbor="Yx0Z8ur6JU6CM5_rwqvx4g">
+        <Tags>
+          <Tag value="Large intestine  neighborhood" />
+          <Tag value="Neighborhood: Plasma / Interstitial" />
+        </Tags>
+        <Children>
+          <Container id="VtT54JE6N0C5mMQsVARwOQ" name="MoleculeProperties" mode="Logical" containerType="Other">
+            <Children>
+              <Parameter id="n3AHGO9cs0iElcGFPEokjA" name="P (plasma&lt;-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
+                <ValueOrigin id="49" source="Other" method="Assumption" description="Assumption: very fast exchange" />
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="134" />
+              </Parameter>
+              <Parameter id="IKqTt-Y_d0G7bYIkCIgRCg" name="Partition coefficient (interstitial/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" isDefault="1">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="148" />
+              </Parameter>
+            </Children>
+          </Container>
+          <Parameter id="6uZpRVvfHEyuoXZFuSGzUw" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" isDefault="1" displayUnit="cm²">
+            <Tags>
+              <Tag value="Large intestine  neighborhood" />
+              <Tag value="Neighborhood: Plasma / Interstitial" />
+            </Tags>
+            <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+            <Info min="0" flag="122" seq="28" ref="0" bb="32" group="106" />
+          </Parameter>
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="2Jfr1ww1iUaUIBMoDsrl0g" name="ArterialBlood_bc_Bone_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="zmZFE8nEqEm0ej9vgvDMqA" secondNeighbor="-7WVSSWNzkKawuJR1P1WQw">
+        <Tags>
+          <Tag value="Neighborhood: BloodCells / BloodCells" />
+        </Tags>
+        <Children>
+          <Container id="urcqach7f0KEOiIxVl_4rQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="5QMKEz5dj0ajqXJ9DRMVLw" name="ArterialBlood_bc_Brain_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="zmZFE8nEqEm0ej9vgvDMqA" secondNeighbor="_kM6rV4F-UGU7WOAUGLsGw">
+        <Tags>
+          <Tag value="Neighborhood: BloodCells / BloodCells" />
+        </Tags>
+        <Children>
+          <Container id="3ntpzglZW0WdV-gyAD2S0w" name="MoleculeProperties" mode="Logical" containerType="Other" />
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="ElK6aZ4caUel-mmS3tngJQ" name="ArterialBlood_bc_Fat_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="zmZFE8nEqEm0ej9vgvDMqA" secondNeighbor="aPjmRFIx1UCuIZcC05FS-Q">
+        <Tags>
+          <Tag value="Neighborhood: BloodCells / BloodCells" />
+        </Tags>
+        <Children>
+          <Container id="AjrdubH-P06Y-gul9SnLnw" name="MoleculeProperties" mode="Logical" containerType="Other" />
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="bVRd7-xmo0ibPldFLZei0g" name="ArterialBlood_bc_Gonads_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="zmZFE8nEqEm0ej9vgvDMqA" secondNeighbor="v8soZXA6DU6TH8algfr0uQ">
+        <Tags>
+          <Tag value="Neighborhood: BloodCells / BloodCells" />
+        </Tags>
+        <Children>
+          <Container id="Df_NZR4-ckqIMZFaCzBT8A" name="MoleculeProperties" mode="Logical" containerType="Other" />
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="Ud-4pvEBckC3gTwLAHaVMg" name="ArterialBlood_bc_Heart_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="zmZFE8nEqEm0ej9vgvDMqA" secondNeighbor="lyEOfc6nTEC9WU3_HrdsZw">
+        <Tags>
+          <Tag value="Neighborhood: BloodCells / BloodCells" />
+        </Tags>
+        <Children>
+          <Container id="lvW4gnuw6kuHG1Y8jRkqaw" name="MoleculeProperties" mode="Logical" containerType="Other" />
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="Sv9KdNi5u0KP9bhk80Igig" name="ArterialBlood_bc_Kidney_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="zmZFE8nEqEm0ej9vgvDMqA" secondNeighbor="BrFx5lvTtUGAhE-smnAxbA">
+        <Tags>
+          <Tag value="Neighborhood: BloodCells / BloodCells" />
+        </Tags>
+        <Children>
+          <Container id="jfqFrrLdwUqhqPLCpBy7Kw" name="MoleculeProperties" mode="Logical" containerType="Other" />
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="a-c33UEm2U61ODy3kxi0ag" name="ArterialBlood_bc_LargeIntestine_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="zmZFE8nEqEm0ej9vgvDMqA" secondNeighbor="hh_A67CorUOAhzpqTVLPOg">
+        <Tags>
+          <Tag value="Neighborhood: BloodCells / BloodCells" />
+        </Tags>
+        <Children>
+          <Container id="WxePb_C_yEufbRUdsBHk5w" name="MoleculeProperties" mode="Logical" containerType="Other" />
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="3z0ATLAVRE2rZje25TAyiA" name="ArterialBlood_bc_Muscle_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="zmZFE8nEqEm0ej9vgvDMqA" secondNeighbor="1sOBPguOQU2A81RiIwHu2A">
+        <Tags>
+          <Tag value="Neighborhood: BloodCells / BloodCells" />
+        </Tags>
+        <Children>
+          <Container id="11n4zcHHuk-R3RVLLhVzYw" name="MoleculeProperties" mode="Logical" containerType="Other" />
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="OZ75kYS9ME-GUEffrma1Cg" name="ArterialBlood_bc_Pancreas_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="zmZFE8nEqEm0ej9vgvDMqA" secondNeighbor="ZLa6meN3FU6VPCDK8AuAZQ">
+        <Tags>
+          <Tag value="Neighborhood: BloodCells / BloodCells" />
+        </Tags>
+        <Children>
+          <Container id="ZGeCxxcmqUuonjIgOfpAOA" name="MoleculeProperties" mode="Logical" containerType="Other" />
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="V0cPlqy10kmSzeNyVCqCxA" name="ArterialBlood_bc_Skin_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="zmZFE8nEqEm0ej9vgvDMqA" secondNeighbor="FiOO7WH94EC7p9ETcLkZFQ">
+        <Tags>
+          <Tag value="Neighborhood: BloodCells / BloodCells" />
+        </Tags>
+        <Children>
+          <Container id="VWKrOJ2JAUqgNANOOcM1Tw" name="MoleculeProperties" mode="Logical" containerType="Other" />
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="mBSuIivoCkilsvoSFKV3Hw" name="ArterialBlood_bc_SmallIntestine_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="zmZFE8nEqEm0ej9vgvDMqA" secondNeighbor="dh_9PrSgd0KpJxAtQiKHRw">
+        <Tags>
+          <Tag value="Neighborhood: BloodCells / BloodCells" />
+        </Tags>
+        <Children>
+          <Container id="r4GXjmCSN0eeLJrh8E0xfQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="p-yvDNMj0UKxCEiCXhTxJw" name="ArterialBlood_bc_Spleen_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="zmZFE8nEqEm0ej9vgvDMqA" secondNeighbor="RA_8UNeBWESbhO5VGxlmJQ">
+        <Tags>
+          <Tag value="Neighborhood: BloodCells / BloodCells" />
+        </Tags>
+        <Children>
+          <Container id="1fUNXjbGHUmIARcjspBDgQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="h8vf4cM7XECq2xHmYRE4Gg" name="ArterialBlood_bc_Stomach_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="zmZFE8nEqEm0ej9vgvDMqA" secondNeighbor="AVrkjZHVYE2BekZ0hnC4Wg">
+        <Tags>
+          <Tag value="Neighborhood: BloodCells / BloodCells" />
+        </Tags>
+        <Children>
+          <Container id="tAHG4_am6Ee3-Eu2dQz5_g" name="MoleculeProperties" mode="Logical" containerType="Other" />
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="ScYJa70OyUuQzaOSH42YOg" name="ArterialBlood_pls_Bone_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="gQ0ACyX0OkaArtZvQ5x4bA" secondNeighbor="FMXrCszwd0aA9SPmflV1pA">
+        <Tags>
+          <Tag value="Neighborhood: Plasma / Plasma" />
+        </Tags>
+        <Children>
+          <Container id="AsoxpT9d7EGNJDMGTliV2Q" name="MoleculeProperties" mode="Logical" containerType="Other" />
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="qgtXnETpJEOEs6tXAzInog" name="ArterialBlood_pls_Brain_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="gQ0ACyX0OkaArtZvQ5x4bA" secondNeighbor="b_tNtdP4bkKB5t081UctTA">
+        <Tags>
+          <Tag value="Neighborhood: Plasma / Plasma" />
+        </Tags>
+        <Children>
+          <Container id="stJg-xm3ak2Z6YusmZqjug" name="MoleculeProperties" mode="Logical" containerType="Other" />
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="VWtE7L0maE-XgmCK17ehhA" name="ArterialBlood_pls_Fat_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="gQ0ACyX0OkaArtZvQ5x4bA" secondNeighbor="eEFhJbl1wESGjgKaGVF2Tw">
+        <Tags>
+          <Tag value="Neighborhood: Plasma / Plasma" />
+        </Tags>
+        <Children>
+          <Container id="5I7MIon_sUi-USMUdJdc6g" name="MoleculeProperties" mode="Logical" containerType="Other" />
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="4QcObe8Jbk6OYKWj6xfdDQ" name="ArterialBlood_pls_Gonads_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="gQ0ACyX0OkaArtZvQ5x4bA" secondNeighbor="9ICTIHrDeES9J29X9SvpgQ">
+        <Tags>
+          <Tag value="Neighborhood: Plasma / Plasma" />
+        </Tags>
+        <Children>
+          <Container id="usWPbfMU8EeMSqaAJuhUCA" name="MoleculeProperties" mode="Logical" containerType="Other" />
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="pn0tmAo5QUK_gJDEvUc-IA" name="ArterialBlood_pls_Heart_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="gQ0ACyX0OkaArtZvQ5x4bA" secondNeighbor="rFnDWJlNa0G4wgk2Zt7Iew">
         <Tags>
-          <Tag value="Large intestine  neighborhood" />
-          <Tag value="Neighborhood: Plasma / BloodCells" />
+          <Tag value="Neighborhood: Plasma / Plasma" />
         </Tags>
         <Children>
-          <Container id="nZQxkSC4NUKj4hj17yLefA" name="MoleculeProperties" mode="Logical" containerType="Other" />
-          <Parameter id="sEZghAScWEqAdCrHdNOAZw" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" isDefault="1" displayUnit="cm²">
-            <Tags>
-              <Tag value="Large intestine  neighborhood" />
-              <Tag value="Neighborhood: Plasma / BloodCells" />
-            </Tags>
-            <Info min="0" flag="122" seq="30" ref="0" bb="32" group="104" />
-          </Parameter>
+          <Container id="ws1xUs8cYkiQQPwYRDUUIg" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="3Y82lWfpykSsfaveS3RdGg" name="ColonSigmoid_pls_ColonSigmoid_int" mode="Logical" containerType="Neighborhood" firstNeighbor="OvLTrMh7lk6jo7evtaDYJg" secondNeighbor="yv_YyAZA6kGkZtTW9kyhcw">
+      <NeighborhoodBuilder id="OGJ_iLHr60CtGo2eZLntIg" name="ArterialBlood_pls_Kidney_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="gQ0ACyX0OkaArtZvQ5x4bA" secondNeighbor="IbVvFDyOgESWto1vT-yhTA">
         <Tags>
-          <Tag value="Large intestine  neighborhood" />
-          <Tag value="Neighborhood: Plasma / Interstitial" />
+          <Tag value="Neighborhood: Plasma / Plasma" />
         </Tags>
         <Children>
-          <Container id="CyF8CzSFqEqUtppAK9DhPg" name="MoleculeProperties" mode="Logical" containerType="Other">
-            <Children>
-              <Parameter id="1ANzfQdIO0CIXhrDYWJsyw" name="Partition coefficient (interstitial/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" isDefault="1">
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="148" />
-              </Parameter>
-              <Parameter id="_zlCGe8EO0-pRNcIIMv-kA" name="P (plasma&lt;-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
-                <ValueOrigin id="49" method="Assumption" description="TODO: Default: very fast exchange" />
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="134" />
-              </Parameter>
-            </Children>
-          </Container>
-          <Parameter id="SREiLQ0HBEeBpqXVZHBYtQ" name="Surface area (plasma/interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" isDefault="1" displayUnit="cm²">
-            <Tags>
-              <Tag value="Large intestine  neighborhood" />
-              <Tag value="Neighborhood: Plasma / Interstitial" />
-            </Tags>
-            <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-            <Info min="0" flag="122" seq="27" ref="0" bb="32" group="106" />
-          </Parameter>
+          <Container id="fHhgKw9y7kOL5eBwiSAPPg" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="CM12dfU7i0SNhKt9u4Z-AA" name="Rectum_pls_Rectum_int" mode="Logical" containerType="Neighborhood" firstNeighbor="0Wkjd6C6ok-KS947nfXutA" secondNeighbor="K1OeylTfR0SqocJXnLob3g">
+      <NeighborhoodBuilder id="hE2UV0Ju9ky4PNIMqiCXUw" name="ArterialBlood_pls_LargeIntestine_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="gQ0ACyX0OkaArtZvQ5x4bA" secondNeighbor="7jE5JCYYHEOTeB85aoJVHw">
         <Tags>
-          <Tag value="Large intestine  neighborhood" />
-          <Tag value="Neighborhood: Plasma / Interstitial" />
+          <Tag value="Neighborhood: Plasma / Plasma" />
         </Tags>
         <Children>
-          <Container id="oDs3LJCwek6nIwxHtNClfg" name="MoleculeProperties" mode="Logical" containerType="Other">
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-                <ValueOrigin id="49" method="Assumption" description="TODO: Default: very fast exchange" />
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="134" />
-              </Parameter>
-              <Parameter id="WurFDSzTakibfBtNcyeKlQ" name="Partition coefficient (interstitial/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" isDefault="1">
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="148" />
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-            <Tags>
-              <Tag value="Large intestine  neighborhood" />
-              <Tag value="Neighborhood: Plasma / Interstitial" />
-            </Tags>
-            <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
-            <Info min="0" flag="122" seq="28" ref="0" bb="32" group="106" />
-          </Parameter>
+          <Container id="M0615zIZpk6o71LXGJ2ZLA" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="pqXCUNtNt0-FJc9mAVu-bA" name="Rectum_int_Rectum_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="K1OeylTfR0SqocJXnLob3g" secondNeighbor="oTMjp1TYnUWpLJraDSSQMA">
+      <NeighborhoodBuilder id="Vk-iY3gj80Gfe3S75RRKag" name="ArterialBlood_pls_Muscle_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="gQ0ACyX0OkaArtZvQ5x4bA" secondNeighbor="__53rbP1vUqN8-pa2a0EGQ">
         <Tags>
-          <Tag value="Large intestine  neighborhood" />
-          <Tag value="Neighborhood: Interstitial / Intracellular" />
+          <Tag value="Neighborhood: Plasma / Plasma" />
         </Tags>
         <Children>
-          <Container id="se1qBGyPxEOCt1GsayNOzQ" name="MoleculeProperties" mode="Logical" containerType="Other">
-            <Children>
-              <Parameter id="8PQIWZ3zz026tcHEdHDHtw" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" isDefault="1">
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
-              </Parameter>
-              <Parameter id="Pa8ZHFiUg0WVbShbYTWbYA" name="P_int_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
-              </Parameter>
-              <Parameter id="zR6Rtnd-g06HtXVmTjyf8g" name="P_cell_int_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" isDefault="1">
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
-              </Parameter>
-              <Parameter id="phFO2aYNRkaqaZrudzJn3g" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" isDefault="1">
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="147" />
-              </Parameter>
-              <Parameter id="ID6U3dzhdUqCP90Z_yG_lw" name="P (interstitial-&gt;intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_int_cell_Mucosa" isDefault="1" displayUnit="cm/min">
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="135" />
-              </Parameter>
-              <Parameter id="EeLDGmyTiUO21jRj-Riiwg" name="P (intracellular-&gt;interstitial)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P_cell_int_Mucosa" isDefault="1" displayUnit="cm/min">
-                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="133" />
-              </Parameter>
-              <Parameter id="D6cSu9SE-E2OoCic_Lj65g" name="P*SA interstitial -&gt; intracellular" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" isDefault="1" displayUnit="l/min">
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
-              </Parameter>
-              <Parameter id="agEhG4iJS0yJC8kARdjcyw" name="P*SA intracellular -&gt; interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" isDefault="1" displayUnit="l/min">
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
-              </Parameter>
-            </Children>
-          </Container>
-          <Parameter id="6H2oYvFtHEK55PFI7gVYtw" name="Surface area (interstitial/intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mucosa_rect" isDefault="1" displayUnit="cm²">
-            <Tags>
-              <Tag value="Large intestine  neighborhood" />
-              <Tag value="Neighborhood: Interstitial / Intracellular" />
-            </Tags>
-            <Info min="0" flag="122" seq="28" ref="0" bb="32" group="105" />
-          </Parameter>
+          <Container id="UyMD5crNH024GCHkbMFK_Q" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="A9h40EMkp0i0vD7c_mjAlA" name="Rectum_pls_Rectum_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="0Wkjd6C6ok-KS947nfXutA" secondNeighbor="82qs1z3BHkWv2WUqNvWppA">
+      <NeighborhoodBuilder id="WFPPfzMyFUuEzq5MasYHQA" name="ArterialBlood_pls_Pancreas_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="gQ0ACyX0OkaArtZvQ5x4bA" secondNeighbor="-nHuc1cRH0moGvDmxl1hTw">
         <Tags>
-          <Tag value="Large intestine  neighborhood" />
-          <Tag value="Neighborhood: Plasma / BloodCells" />
+          <Tag value="Neighborhood: Plasma / Plasma" />
         </Tags>
         <Children>
-          <Container id="uIvirGTzekGZ4Ke_zZMbSQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
-          <Parameter id="TFNMzPq05EOhFRXDJ-uvYg" name="Surface area (blood cells/plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" isDefault="1" displayUnit="cm²">
-            <Tags>
-              <Tag value="Large intestine  neighborhood" />
-              <Tag value="Neighborhood: Plasma / BloodCells" />
-            </Tags>
-            <Info min="0" flag="122" seq="31" ref="0" bb="32" group="104" />
-          </Parameter>
+          <Container id="Za16uTnTDE6V248b1HcLUQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="9lrN-sOnm0mmmgJ7YSOqAQ" name="ArterialBlood_pls_SmallIntestine_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="bS-sGM903k-X6Tuo2p8Ujw" secondNeighbor="YZG2svoXwkCXDQCWhthiGQ">
+      <NeighborhoodBuilder id="LsKXZB7i_UKSriufo2Aldw" name="ArterialBlood_pls_Skin_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="gQ0ACyX0OkaArtZvQ5x4bA" secondNeighbor="kO0daEk3LUG7zEtqAh9fyQ">
         <Tags>
           <Tag value="Neighborhood: Plasma / Plasma" />
         </Tags>
         <Children>
-          <Container id="LrjtzcXFzkmcGD79XLrrLQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="FEN_YhEvuE2vKHa8D5SrlQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="JN44TOP40k6-Hfsb_uW0_Q" name="ArterialBlood_pls_Spleen_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="bS-sGM903k-X6Tuo2p8Ujw" secondNeighbor="ACfXTDO_GUup1aBj-xeGyg">
+      <NeighborhoodBuilder id="ImxDzPoJakiBdVoNVi-Cgw" name="ArterialBlood_pls_SmallIntestine_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="gQ0ACyX0OkaArtZvQ5x4bA" secondNeighbor="Vxis-jG0SEele2dNhDDVJg">
         <Tags>
           <Tag value="Neighborhood: Plasma / Plasma" />
         </Tags>
         <Children>
-          <Container id="NJiNVz_nd02UixqslI4GyA" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="ZKqP_fBTyU6hXJ9lVQWSCA" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="Q-je6AVdEESj9d_HHCD7jg" name="ArterialBlood_pls_Stomach_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="bS-sGM903k-X6Tuo2p8Ujw" secondNeighbor="w7fjJlr-C0KeticP__wcVg">
+      <NeighborhoodBuilder id="hTTm-JHXMkqH__MI8C2M4Q" name="ArterialBlood_pls_Spleen_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="gQ0ACyX0OkaArtZvQ5x4bA" secondNeighbor="PF2p7IEtQ0aLG7Gj7WfJcw">
         <Tags>
           <Tag value="Neighborhood: Plasma / Plasma" />
         </Tags>
         <Children>
-          <Container id="DD-6q4XF1U2FfPPxqSNLQw" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="qjKVgtKRUUmbhEAvebuzOQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="jBF6c0bN_kSMPh-ISrdhAg" name="Lumen_duo_Duodenum_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="R6oHTJqg9kGzj5KJS4zGGg" secondNeighbor="PdhUdIESUEalieeUeCgevg">
+      <NeighborhoodBuilder id="lcZeHjPURkq8WeOj3IJeCg" name="ArterialBlood_pls_Stomach_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="gQ0ACyX0OkaArtZvQ5x4bA" secondNeighbor="zuvUyT7oak2Zhtu8j2cZMg">
         <Tags>
-          <Tag value="Neighborhood: Duodenum / Intracellular" />
+          <Tag value="Neighborhood: Plasma / Plasma" />
+        </Tags>
+        <Children>
+          <Container id="Mx3qF24QYEO-4TqQ0ba4zg" name="MoleculeProperties" mode="Logical" containerType="Other" />
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="27o6g4syLESwLsW33fYWCQ" name="Lumen_duo_Duodenum_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="1WeVhpyE0E2FsX9S1BNctw" secondNeighbor="C-d2PMLTSE2CX0a7o185GA">
+        <Tags>
+          <Tag value="Neighborhood: Duodenum / Plasma" />
         </Tags>
         <Children>
-          <Container id="gx8WIiXlRk60Q6l7Ee-r1Q" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="YPYRw-q1TEW_i-wAIBaGgg" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="5-eZIZ1blUGrwMbJiQEbqw" name="pKa_pH_WS_cell_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K7" isDefault="1">
-                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              <Parameter id="oHLXVGfZtkm3EcBzQGZOcg" name="Drug absorption rate (lumen to mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_DrugAbsorption_para" isDefault="1" displayUnit="µmol/min">
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
               </Parameter>
-              <Parameter id="FQKMle6FXUi0pXzesSo89g" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_Duodenum" isDefault="1">
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+              <Parameter id="m2hc4eJYo02rmqZ4LytCzw" name="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" isDefault="1" displayUnit="µmol/min">
+                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
               </Parameter>
-              <Parameter id="G3hqqRFIa0uy8YYweqo05Q" name="pKa_pH_WS_cell_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F1" isDefault="1">
-                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              <Parameter id="enPArnSw90KNOgIPxfldYQ" name="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" isDefault="1" displayUnit="µmol/min">
+                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
               </Parameter>
-              <Parameter id="jGEGc9rTs0mEzENcyhkKEw" name="pKa_pH_WS_cell_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F2" isDefault="1">
-                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+            </Children>
+          </Container>
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="nzGN_zL8K0esKS1bxtknLQ" name="Lumen_duo_Duodenum_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="1WeVhpyE0E2FsX9S1BNctw" secondNeighbor="zbImQfwyxkWPq_gPbXufRw">
+        <Tags>
+          <Tag value="Neighborhood: Duodenum / Intracellular" />
+        </Tags>
+        <Children>
+          <Container id="HQLtsaxK5U-ghSx_aDB5OA" name="MoleculeProperties" mode="Logical" containerType="Other">
+            <Children>
+              <Parameter id="kqQtL1s78EqFrePv2XRGKg" name="Drug absorption rate (lumen to mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_DrugAbsorption_trans" isDefault="1" displayUnit="µmol/min">
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
               </Parameter>
-              <Parameter id="KQE3FOutI0mvFfy3o08liA" name="pKa_pH_WS_cell_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F3" isDefault="1">
+              <Parameter id="kf6JP2PC2Uy3BRm99eBAKA" name="P_int_trans_cell_lum_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_cell_lum_factor" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="-afFrZ43I06r3Fq3SciX6Q" name="pKa_pH_WS_cell_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K1" isDefault="1">
+              <Parameter id="SkCQP3IG8U-B5mhu-aEuFA" name="P_int_trans_lum_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_lum_cell_factor" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="idMjU2CKd0Cp9BqIbw_euA" name="pKa_pH_WS_cell_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K2" isDefault="1">
-                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              <Parameter id="phh2mkiK80exubK-SzQUiw" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_K_cell_pls_Duodenum" isDefault="1">
+                <Info min="0" flag="36" seq="1" ref="0" bb="2" group="67" />
               </Parameter>
-              <Parameter id="wC-jlH0DbkGFaqLBj1-d7A" name="pKa_pH_WS_cell_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K3" isDefault="1">
-                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              <Parameter id="rJy4ErbQzEOalvLGHndkWQ" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_Duodenum" isDefault="1">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
               </Parameter>
-              <Parameter id="DgoVC7eYDUqXckfLD0LBHA" name="pKa_pH_WS_cell_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K4" isDefault="1">
+              <Parameter id="jiSkwhNh0U2QVkwC_U1NzQ" name="pKa_pH_WS_cell_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F1" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="61sk8lL-mESDCrKww3BSJA" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K5" isDefault="1">
+              <Parameter id="dwpcjfTjqEKBCl_GVZhoOQ" name="pKa_pH_WS_cell_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F2" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="_FchO1ig_0GvoK5b_iAEhA" name="pKa_pH_WS_cell_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K6" isDefault="1">
+              <Parameter id="YFbFShO8LUSbDp9A4K67KQ" name="pKa_pH_WS_cell_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F3" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="3MwQtKdMR0q_a2iXHIEMrA" name="P_int_trans_cell_lum_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_cell_lum_factor" isDefault="1">
+              <Parameter id="DLve2Vg1nEua1COTSqUS7g" name="pKa_pH_WS_cell_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K1" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="0mSWZOILo0uzZcqt3oz63g" name="pKa_pH_WS_cell_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K8" isDefault="1">
+              <Parameter id="ITEjQf1yZkq7SXjiqXGsrg" name="pKa_pH_WS_cell_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K2" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="B2udpjYDqEqJyYg9QuRy9Q" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F1" isDefault="1">
+              <Parameter id="tFF0HgGQcEalIS5BPkaUNA" name="pKa_pH_WS_cell_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K3" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="XI11-HI0PkuzpbuK67ypJw" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F2" isDefault="1">
+              <Parameter id="6momn-q0dEOE-jTlUCSVbA" name="pKa_pH_WS_cell_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K4" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="2Tg7dwx4kEuM7poRXdcgXw" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F3" isDefault="1">
+              <Parameter id="d5lrnEKY9kO1mU36AXdkDQ" name="pKa_pH_WS_cell_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K5" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="DVN9B1HREEKzcZZrpg93Kg" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K1" isDefault="1">
+              <Parameter id="kK1UAKgxrk-qFF8uB6anEw" name="pKa_pH_WS_cell_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K6" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="lA8yUcl0QUCrmPEniVky7Q" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K2" isDefault="1">
+              <Parameter id="KDmPRzkK4UitEFE11N2qjg" name="pKa_pH_WS_cell_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K7" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="DFSHAu5bDUCy3bgAyTK2jQ" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K3" isDefault="1">
+              <Parameter id="ScjiDfbc0k-QZ5DfQa2_-A" name="pKa_pH_WS_cell_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K8" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="1-eephuZVk2_iSBB9_6pag" name="pKa_pH_WS_cell_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K5" isDefault="1">
+              <Parameter id="5uo2Exurk0mqBfJbe07NoQ" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F1" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="IQ4GP5F4fEiAtglOlWuJyg" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_K_cell_pls_Duodenum" isDefault="1">
-                <Info min="0" flag="36" seq="1" ref="0" bb="2" group="67" />
+              <Parameter id="HoyvR4emVUyXR11u3__PAQ" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F2" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="_eASc2KM_0C4ZzAi6_zAnQ" name="P_int_trans_lum_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_lum_cell_factor" isDefault="1">
+              <Parameter id="Kcbv4xLwZ0iNagqC397TXg" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F3" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="FYtPRTdauEyUeGLf8Yfmmw" name="Drug absorption rate (lumen to mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_DrugAbsorption_trans" isDefault="1" displayUnit="µmol/min">
-                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+              <Parameter id="9mxqYHxVdkq1snB_hXBQmQ" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K1" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="qyD1pii_OE-CECnwYSicwA" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K6" isDefault="1">
+              <Parameter id="zYD4_vW2dECOy72TMRszuA" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K2" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="6SlcWvUYNUeu_5nd4uQ35Q" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K4" isDefault="1">
+              <Parameter id="0rmKWdCCFUysJMTkQT21Vg" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K3" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="_OmI1Vm90EGOzaRUZjMdlQ" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K7" isDefault="1">
+              <Parameter id="WdfpYPRVRUigY4X7IvTqlA" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K4" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="yw1w22KakkWgxEmMBUBlUQ" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K8" isDefault="1">
+              <Parameter id="wwp8hcEqY0G339aoQ9rx6Q" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K5" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="_QNJi8ZEEkmc4hOh9rK4pg" name="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" isDefault="1" displayUnit="µmol/min">
-                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+              <Parameter id="G_UfzmIoGU609RgLbHJI8g" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K6" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="1E5f66Bnk0aXkZ49YmWGTA" name="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" isDefault="1" displayUnit="µmol/min">
-                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+              <Parameter id="u6QWkTFLFUWi93VemHJIVQ" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K7" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-            </Children>
-          </Container>
-        </Children>
-      </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="SKCQdNb37UychfjXGWPgTQ" name="ArterialBlood_pls_Kidney_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="bS-sGM903k-X6Tuo2p8Ujw" secondNeighbor="YunXrm_uA0GVV6ozN-56Xw">
-        <Tags>
-          <Tag value="Neighborhood: Plasma / Plasma" />
-        </Tags>
-        <Children>
-          <Container id="QUVbMBBFT0yKy-ON3Eyylw" name="MoleculeProperties" mode="Logical" containerType="Other" />
-        </Children>
-      </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="tSfRfjoFe0SoulhvAfXaAA" name="Lumen_duo_Duodenum_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="R6oHTJqg9kGzj5KJS4zGGg" secondNeighbor="3_a1oSiNnkisFIFOu3c1zw">
-        <Tags>
-          <Tag value="Neighborhood: Duodenum / Plasma" />
-        </Tags>
-        <Children>
-          <Container id="IPnH9HWyZEC16miMY5_mFw" name="MoleculeProperties" mode="Logical" containerType="Other">
-            <Children>
-              <Parameter id="zTvy5HqivEeaWuMaxrJHww" name="Drug absorption rate (lumen to mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_DrugAbsorption_para" isDefault="1" displayUnit="µmol/min">
-                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+              <Parameter id="0vD2gypuJU6UXigX7WkNGw" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K8" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="FvkCXgXU-kOhtJCamk4qng" name="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" isDefault="1" displayUnit="µmol/min">
+              <Parameter id="rPr9Wb4vi0S9gZdcTvK2YA" name="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" isDefault="1" displayUnit="µmol/min">
                 <Info flag="52" seq="1" ref="0" bb="2" group="117" />
               </Parameter>
-              <Parameter id="CUxD8W0cN0iAzzgXfA6h7Q" name="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" isDefault="1" displayUnit="µmol/min">
+              <Parameter id="AbTI_m0gLUKOzdZH_rlzOA" name="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" isDefault="1" displayUnit="µmol/min">
                 <Info flag="52" seq="1" ref="0" bb="2" group="117" />
               </Parameter>
             </Children>
           </Container>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="Ihs-g62uGEmJmS-lAnqtRQ" name="ArterialBlood_pls_Fat_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="bS-sGM903k-X6Tuo2p8Ujw" secondNeighbor="kDtt8apkd0ilEw0l7X3Efw">
-        <Tags>
-          <Tag value="Neighborhood: Plasma / Plasma" />
-        </Tags>
-        <Children>
-          <Container id="922jqSbu70mlZa_ulNrDGA" name="MoleculeProperties" mode="Logical" containerType="Other" />
-        </Children>
-      </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="ayXJcvYAME61uynRaOCp4Q" name="ArterialBlood_pls_Gonads_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="bS-sGM903k-X6Tuo2p8Ujw" secondNeighbor="dQYkOM8WRUWsb3Hw5kGAzQ">
-        <Tags>
-          <Tag value="Neighborhood: Plasma / Plasma" />
-        </Tags>
-        <Children>
-          <Container id="amhoYVDJD0eogN94doej4A" name="MoleculeProperties" mode="Logical" containerType="Other" />
-        </Children>
-      </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="gcldxeT43USySiaMobELKQ" name="ArterialBlood_pls_Heart_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="bS-sGM903k-X6Tuo2p8Ujw" secondNeighbor="H8M1nNf2m0a9F4rb9_ggMg">
-        <Tags>
-          <Tag value="Neighborhood: Plasma / Plasma" />
-        </Tags>
-        <Children>
-          <Container id="YF6iN2mLz0Oa0KNiEGzkEg" name="MoleculeProperties" mode="Logical" containerType="Other" />
-        </Children>
-      </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="KYfCN3Z10keLdCpdub78Dg" name="ArterialBlood_pls_Muscle_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="bS-sGM903k-X6Tuo2p8Ujw" secondNeighbor="2LI7MHC5ZUe9U4VNvxVI9w">
-        <Tags>
-          <Tag value="Neighborhood: Plasma / Plasma" />
-        </Tags>
-        <Children>
-          <Container id="1KUKMcEy80OviMIIXz5z0A" name="MoleculeProperties" mode="Logical" containerType="Other" />
-        </Children>
-      </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="2AYwlJJock-NZsjc-ECXRA" name="ArterialBlood_pls_Skin_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="bS-sGM903k-X6Tuo2p8Ujw" secondNeighbor="TBOCHId7jEytRA-_hVQFnA">
-        <Tags>
-          <Tag value="Neighborhood: Plasma / Plasma" />
-        </Tags>
-        <Children>
-          <Container id="5w4y72g4mUaCCz-OvF9zLQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
-        </Children>
-      </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="KtCxjgQkPEqmBMMhORwdqA" name="ArterialBlood_pls_LargeIntestine_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="bS-sGM903k-X6Tuo2p8Ujw" secondNeighbor="S4vsJ43EMEq3UIHZ_UQ7RA">
-        <Tags>
-          <Tag value="Neighborhood: Plasma / Plasma" />
-        </Tags>
-        <Children>
-          <Container id="2IoI08th9UqXTvOLyVhbeg" name="MoleculeProperties" mode="Logical" containerType="Other" />
-        </Children>
-      </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="VEtBlO9GGUyeMxu6X4MZzQ" name="ArterialBlood_pls_Pancreas_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="bS-sGM903k-X6Tuo2p8Ujw" secondNeighbor="4f6Tr0fjFEihF5_rAmMPMw">
+      <NeighborhoodBuilder id="U5TTY19WzkuUoG54qfeafQ" name="Duodenum_pls_PortalVein_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="C-d2PMLTSE2CX0a7o185GA" secondNeighbor="vihskj6fJkaqqVik0r1DIg">
         <Tags>
           <Tag value="Neighborhood: Plasma / Plasma" />
         </Tags>
         <Children>
-          <Container id="92_AUnQzR0y76W89-qQzZA" name="MoleculeProperties" mode="Logical" containerType="Other" />
-        </Children>
-      </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="FiMEQ-5cJEihE2Lgz3EKtQ" name="ColonSigmoid_bc_PortalVein_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="saCFzb5mNkqDgp9lSJDPtQ" secondNeighbor="-ce4W1W9u0-sDuce1ufJ_A">
-        <Tags>
-          <Tag value="Neighborhood: BloodCells / BloodCells" />
-        </Tags>
-        <Children>
-          <Container id="FmAywSfWAE2UMiT0Gozf8w" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="EG5xHDr1MkKE91rX0sb0KQ" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="a1j11-Zc1E262C-bdaiTjQ" name="Mass transfer rate (mucosa to portal vein blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPveBloodCells" isDefault="1" displayUnit="µmol/min">
+              <Parameter id="cx1oRGBCPUaj9CrWOlNatQ" name="Mass transfer rate (mucosa to portal vein plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPvePlasma" isDefault="1" displayUnit="µmol/min">
                 <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                 <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
               </Parameter>
@@ -18023,34 +18216,14 @@
           </Container>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="LDPJ7cB19UisjhY4tw66KA" name="Lumen_colsigm_ColonSigmoid_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="IUIlF5c6mEeLyH0-jGRL5g" secondNeighbor="OvLTrMh7lk6jo7evtaDYJg">
-        <Tags>
-          <Tag value="Neighborhood: ColonSigmoid / Plasma" />
-        </Tags>
-        <Children>
-          <Container id="cxXWpqLS7UCaha5hMI-s-Q" name="MoleculeProperties" mode="Logical" containerType="Other">
-            <Children>
-              <Parameter id="VwyjLc1a4ku7Z3XszwXwgg" name="Drug absorption rate (lumen to mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_DrugAbsorption_para" isDefault="1" displayUnit="µmol/min">
-                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
-              </Parameter>
-              <Parameter id="LSvRoESMkEKLOkvHXHepvw" name="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" isDefault="1" displayUnit="µmol/min">
-                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
-              </Parameter>
-              <Parameter id="OdcKC-NTtEGQH3UaYUnAjQ" name="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" isDefault="1" displayUnit="µmol/min">
-                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
-              </Parameter>
-            </Children>
-          </Container>
-        </Children>
-      </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="x5mngf90bkmlzJlnRC5Jaw" name="ColonSigmoid_pls_PortalVein_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="OvLTrMh7lk6jo7evtaDYJg" secondNeighbor="meWL4gPZR0uFouhVl8UsOw">
+      <NeighborhoodBuilder id="8CWOYNe9cEGSobn4Qd201Q" name="Duodenum_bc_PortalVein_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="nwFYd1vNG0uI8cY3lrK-Zw" secondNeighbor="eN7tQLMOREG3-_sYJSczng">
         <Tags>
-          <Tag value="Neighborhood: Plasma / Plasma" />
+          <Tag value="Neighborhood: BloodCells / BloodCells" />
         </Tags>
         <Children>
-          <Container id="T1JRy5ANCEqPKG1qhzd8mQ" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="YJlEzzixTE2ARAEDAHMYKg" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="LTaqeQRRoEiPVk5UhMTQWA" name="Mass transfer rate (mucosa to portal vein plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPvePlasma" isDefault="1" displayUnit="µmol/min">
+              <Parameter id="ArrmLQZ-H0ytyhyusY1k3Q" name="Mass transfer rate (mucosa to portal vein blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPveBloodCells" isDefault="1" displayUnit="µmol/min">
                 <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                 <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
               </Parameter>
@@ -18058,167 +18231,132 @@
           </Container>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="EH3Pqn_WnEGq0TEyzFZfsQ" name="Lumen_cae_Caecum_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="1Yph3j4_2EWXIUkeJgtkTg" secondNeighbor="LzJaekJVEUe4P9I9KnDGkQ">
+      <NeighborhoodBuilder id="LIUhaCcnDEOEZLT89BWVBg" name="Lumen_cae_Caecum_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="kGnbkD3u90iwTRcuuGciQQ" secondNeighbor="ZxVt3miuQEiGCJszptmYuQ">
         <Tags>
           <Tag value="Neighborhood: Caecum / Plasma" />
         </Tags>
         <Children>
-          <Container id="cRdV3kEJNUego7RcEH60kQ" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="qOJv7y3I5kKweFujkR6quA" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="gaA36xCFJ02_nIZfOpbL9g" name="Drug absorption rate (lumen to mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_DrugAbsorption_para" isDefault="1" displayUnit="µmol/min">
+              <Parameter id="PAL5DFfpfUmx5wge4PNd1A" name="Drug absorption rate (lumen to mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_DrugAbsorption_para" isDefault="1" displayUnit="µmol/min">
                 <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
               </Parameter>
-              <Parameter id="LRjLE6ZYvUespkC2gJyH_w" name="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" isDefault="1" displayUnit="µmol/min">
+              <Parameter id="OV7CYrxfbE-VIvaaWn5zhg" name="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" isDefault="1" displayUnit="µmol/min">
                 <Info flag="52" seq="1" ref="0" bb="2" group="117" />
               </Parameter>
-              <Parameter id="S9yV3kdMy0GxMklR_3ViQQ" name="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" isDefault="1" displayUnit="µmol/min">
+              <Parameter id="Aot2JmPjXEKFb1xLsvZbFA" name="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" isDefault="1" displayUnit="µmol/min">
                 <Info flag="52" seq="1" ref="0" bb="2" group="117" />
               </Parameter>
             </Children>
           </Container>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="vySuDEpFGUq4h4bbo96HBg" name="Lumen_cae_Caecum_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="1Yph3j4_2EWXIUkeJgtkTg" secondNeighbor="Si0F6PmVv0qRnmm7cbWb5A">
+      <NeighborhoodBuilder id="XJGgFiDNZ02CqHYp37N4zQ" name="Lumen_cae_Caecum_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="kGnbkD3u90iwTRcuuGciQQ" secondNeighbor="9T8VbJMx3kaUZwobqt8v9w">
         <Tags>
           <Tag value="Neighborhood: Caecum / Intracellular" />
         </Tags>
         <Children>
-          <Container id="nRVq9xJ1_EKcRYLbFugCQg" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="Yzd4B8qdHk-8BBSI2ueFGQ" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="ATKKRrkoWkOneuNztRm9IQ" name="Drug absorption rate (lumen to mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_DrugAbsorption_trans" isDefault="1" displayUnit="µmol/min">
+              <Parameter id="p7YtG4AfA02XsgkjvoZRCA" name="Drug absorption rate (lumen to mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_DrugAbsorption_trans" isDefault="1" displayUnit="µmol/min">
                 <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
               </Parameter>
-              <Parameter id="Q9zdyRcCvEyWqfX6kuKUog" name="P_int_trans_cell_lum_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_cell_lum_factor" isDefault="1">
+              <Parameter id="Gbix_m8MBU-tWjnK9GeRfw" name="P_int_trans_cell_lum_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_cell_lum_factor" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="IguR-EuLuEakbD2v1DvdFA" name="P_int_trans_lum_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_lum_cell_factor" isDefault="1">
+              <Parameter id="p5oxNbJQXkincVUhsbyGGw" name="P_int_trans_lum_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_lum_cell_factor" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="dxLfVCAJAEeXjX_8jtFpzQ" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_K_cell_pls_Caecum" isDefault="1">
+              <Parameter id="U243QFEAbkua-tS3rJZWNA" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_K_cell_pls_Caecum" isDefault="1">
                 <Info min="0" flag="36" seq="1" ref="0" bb="2" group="67" />
               </Parameter>
-              <Parameter id="QYrt9v0Wb0air3bTQ7DmQQ" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_Caecum" isDefault="1">
+              <Parameter id="5QCvdFIR50St-0Wzur0AGw" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_Caecum" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
               </Parameter>
-              <Parameter id="5Aa0UjXzDE-iIa4rlmiBZQ" name="pKa_pH_WS_cell_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F3" isDefault="1">
+              <Parameter id="g9V7d6zFVkKFgLWGGgIHRg" name="pKa_pH_WS_cell_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F1" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="7vlS2f9w50mpvmY1PEJLyw" name="pKa_pH_WS_cell_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F1" isDefault="1">
+              <Parameter id="Odwh2m_aKUGBi6AOOchbmw" name="pKa_pH_WS_cell_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F2" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="7aeFsmrhpkKvcJY8LqaCaw" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K2" isDefault="1">
+              <Parameter id="DF1H-xNZJkOGgWVzIV0VIw" name="pKa_pH_WS_cell_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F3" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="Xk0hINqxhkCRgj_MGdoCAw" name="pKa_pH_WS_cell_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K1" isDefault="1">
+              <Parameter id="WIlFo0_Hjk-N_SnZzc6IPg" name="pKa_pH_WS_cell_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K1" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="ZlOXM9A6vEyjGdZqfeZgUQ" name="pKa_pH_WS_cell_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K2" isDefault="1">
+              <Parameter id="vcIjX_40REOLQNziwOe7dQ" name="pKa_pH_WS_cell_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K2" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="Ja8WLHV7sUCvAjqNypk8HQ" name="pKa_pH_WS_cell_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K3" isDefault="1">
+              <Parameter id="N5MDX1cYHEOfY4Pjeub9Dw" name="pKa_pH_WS_cell_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K3" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="pC4qbezZpUuvwrIZQwhNrQ" name="pKa_pH_WS_cell_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K4" isDefault="1">
+              <Parameter id="MpUc1cdEAEWz-_8zkJsspA" name="pKa_pH_WS_cell_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K4" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="PzE6B2BRL06dP5gmebrn9Q" name="pKa_pH_WS_cell_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K5" isDefault="1">
+              <Parameter id="7pe5ts0Eg0elJGGe1E-MYQ" name="pKa_pH_WS_cell_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K5" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="HFBrlp_dT02y_ZT2qEjrBw" name="pKa_pH_WS_cell_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K6" isDefault="1">
+              <Parameter id="Q5xM89gHcUqsfGfFdqrdNA" name="pKa_pH_WS_cell_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K6" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="FzCbIj-MDEaUSiglojRaLw" name="pKa_pH_WS_cell_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K7" isDefault="1">
+              <Parameter id="xTGjl9fmgUeItb4H8Nwx-g" name="pKa_pH_WS_cell_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K7" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="g6kfxWeUW0im_GX_tyJSUw" name="pKa_pH_WS_cell_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K8" isDefault="1">
+              <Parameter id="tSoI7KzpzEyr2iJsievA5g" name="pKa_pH_WS_cell_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K8" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="byCZhRMbTUOqGl3ZpRSJtA" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F1" isDefault="1">
+              <Parameter id="ocE4jCeBT0mrRt3W718exw" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F1" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="J7QLDVnniUK2_ADnx7JkAg" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F2" isDefault="1">
+              <Parameter id="-eafBIWdL0OexF9Rw7TRDA" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F2" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="A4l0CKI9U068OYL1CEXniQ" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K1" isDefault="1">
+              <Parameter id="hdP73OCnHkuq--IcFG-Q2Q" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F3" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="VbXvTV_fLEm-tFqG956irw" name="pKa_pH_WS_cell_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F2" isDefault="1">
+              <Parameter id="lgvh9IkST0q9arJVOUSFcQ" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K1" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="rpgPZ_G3ekaKEGwYl29dHw" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K3" isDefault="1">
+              <Parameter id="bxs2tqPc7Ey8ClijEOaARQ" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K2" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="m8my7Nin4U2QjfujIjFQNA" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K4" isDefault="1">
+              <Parameter id="uUF0jL0d-kGe1SMFhrnITQ" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K3" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="VLyJ3U0wk06VL5gSl6Flqw" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K5" isDefault="1">
+              <Parameter id="yzmZxet8uE6toKIcjgkXqg" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K4" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="wb2iMLsqFUWr4nuFQChOxQ" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K6" isDefault="1">
+              <Parameter id="1ThPqmSPt0-C5sU2DLu6DA" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K5" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="UKuFEXayx0G5Y_YXCkJC9g" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K7" isDefault="1">
+              <Parameter id="ot_H1Us03ky2Jh01_Nja5A" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K6" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="ErDM2B4H70ukkYi7k4gtbA" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K8" isDefault="1">
+              <Parameter id="0i_iYPEBXUS4YlbHgI8aCA" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K7" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="uffWkhSiZECphLg8lhB0Ww" name="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" isDefault="1" displayUnit="µmol/min">
-                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
-              </Parameter>
-              <Parameter id="I3lKKBz4NUOwM2yl0fhMDA" name="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" isDefault="1" displayUnit="µmol/min">
-                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
-              </Parameter>
-              <Parameter id="TP2h45PYcUyL_3PNOL8oUg" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F3" isDefault="1">
+              <Parameter id="Vzcgj_8RVkOyL7ISoXLXsQ" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K8" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-            </Children>
-          </Container>
-        </Children>
-      </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="TP6rwfhFgUOo8rNG-yPb-g" name="Duodenum_bc_PortalVein_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="H5K_385D-UCbaUAkVzKFPA" secondNeighbor="-ce4W1W9u0-sDuce1ufJ_A">
-        <Tags>
-          <Tag value="Neighborhood: BloodCells / BloodCells" />
-        </Tags>
-        <Children>
-          <Container id="lN--vJE5a0KflX97w6DPMg" name="MoleculeProperties" mode="Logical" containerType="Other">
-            <Children>
-              <Parameter id="2VfSMRytnEG0FZvHLQ_Eng" name="Mass transfer rate (mucosa to portal vein blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPveBloodCells" isDefault="1" displayUnit="µmol/min">
-                <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
-                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
-              </Parameter>
-            </Children>
-          </Container>
-        </Children>
-      </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="AV6yT7V0f0WOJXd04_lwWw" name="Lumen_coltrans_ColonTransversum_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="ulKpUIAAi06wltlr56erzQ" secondNeighbor="bmNZtt8nFEaRbFLVSheTLQ">
-        <Tags>
-          <Tag value="Neighborhood: ColonTransversum / Plasma" />
-        </Tags>
-        <Children>
-          <Container id="XidE-04sCUOnFbXz4E5yGw" name="MoleculeProperties" mode="Logical" containerType="Other">
-            <Children>
-              <Parameter id="KNKT5deWF0SQF3D6kL5xgw" name="Drug absorption rate (lumen to mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_DrugAbsorption_para" isDefault="1" displayUnit="µmol/min">
-                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
-              </Parameter>
-              <Parameter id="aA944zVS10avZ_w99ZlYjw" name="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" isDefault="1" displayUnit="µmol/min">
+              <Parameter id="arUjImbU4U-8P_xw61-nkg" name="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" isDefault="1" displayUnit="µmol/min">
                 <Info flag="52" seq="1" ref="0" bb="2" group="117" />
               </Parameter>
-              <Parameter id="n-48aZM1HEK5V0TLGsp3cA" name="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" isDefault="1" displayUnit="µmol/min">
+              <Parameter id="7p9Q6zyPtEqOSgiCTL-e5Q" name="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" isDefault="1" displayUnit="µmol/min">
                 <Info flag="52" seq="1" ref="0" bb="2" group="117" />
               </Parameter>
             </Children>
           </Container>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="3rs5sUHvn0OjubkU4VL51w" name="Duodenum_pls_PortalVein_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="3_a1oSiNnkisFIFOu3c1zw" secondNeighbor="meWL4gPZR0uFouhVl8UsOw">
+      <NeighborhoodBuilder id="q6RdLEUI60Gd-avjk1fXJA" name="Caecum_pls_PortalVein_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="ZxVt3miuQEiGCJszptmYuQ" secondNeighbor="vihskj6fJkaqqVik0r1DIg">
         <Tags>
           <Tag value="Neighborhood: Plasma / Plasma" />
         </Tags>
         <Children>
-          <Container id="dGLZncWXWEunLnbvsmr3kw" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="mMKGMN-nJ0i9r0xV69VOug" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="ukvO51BbRE2WfOwuoBAlTQ" name="Mass transfer rate (mucosa to portal vein plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPvePlasma" isDefault="1" displayUnit="µmol/min">
+              <Parameter id="z3EbWnhKc06LlX6ZPdvcDw" name="Mass transfer rate (mucosa to portal vein plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPvePlasma" isDefault="1" displayUnit="µmol/min">
                 <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                 <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
               </Parameter>
@@ -18226,14 +18364,14 @@
           </Container>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="i9AmoB5SBEiTaZ-RhW3BEw" name="ColonDescendens_bc_PortalVein_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="XocTM5veBEGBOOmndILFgg" secondNeighbor="-ce4W1W9u0-sDuce1ufJ_A">
+      <NeighborhoodBuilder id="uYIcFymrVEu0Q_fCCva4ig" name="Caecum_bc_PortalVein_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="NugBHVuOHEervTrkBVs4wg" secondNeighbor="eN7tQLMOREG3-_sYJSczng">
         <Tags>
           <Tag value="Neighborhood: BloodCells / BloodCells" />
         </Tags>
         <Children>
-          <Container id="2YwtDdFUbkm7ThfDBlE5Mw" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="lCVIvBK2w0u_ST0WitNVkw" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="HOEAne1Bx0etAdJR0aHRvQ" name="Mass transfer rate (mucosa to portal vein blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPveBloodCells" isDefault="1" displayUnit="µmol/min">
+              <Parameter id="2pewNqQbhEyKr3XhEO1EAw" name="Mass transfer rate (mucosa to portal vein blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPveBloodCells" isDefault="1" displayUnit="µmol/min">
                 <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                 <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
               </Parameter>
@@ -18241,358 +18379,428 @@
           </Container>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="_wmML1_MekOh00xPETNE7g" name="ColonDescendens_pls_PortalVein_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="IUx7uFw2hEyGTiqkSDgZaQ" secondNeighbor="meWL4gPZR0uFouhVl8UsOw">
+      <NeighborhoodBuilder id="zvWeeuX8tEeF_Zx02HJLXw" name="Lumen_colasc_ColonAscendens_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="B6U75mASo02V01eMygYROA" secondNeighbor="Enan29lQuku7kissDlHImQ">
         <Tags>
-          <Tag value="Neighborhood: Plasma / Plasma" />
+          <Tag value="Neighborhood: ColonAscendens / Plasma" />
         </Tags>
         <Children>
-          <Container id="uNrmKHadikez44cGXyxt2A" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="loRVB5-Ia0O1tuolYzN_YA" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="W0rUfNYstUa14urvfJ7nSg" name="Mass transfer rate (mucosa to portal vein plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPvePlasma" isDefault="1" displayUnit="µmol/min">
-                <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+              <Parameter id="wjUerLmjrk2s3gUMwvrV2g" name="Drug absorption rate (lumen to mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_DrugAbsorption_para" isDefault="1" displayUnit="µmol/min">
                 <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
               </Parameter>
+              <Parameter id="2bNCH5cinU2RQpOjGExeLg" name="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" isDefault="1" displayUnit="µmol/min">
+                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
+              <Parameter id="QHZOW3J5LEyrEdNP6dQjpQ" name="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" isDefault="1" displayUnit="µmol/min">
+                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
             </Children>
           </Container>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="E7VkZwqYr0m8V3yhdccFUQ" name="Lumen_coldesc_ColonDescendens_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="JbHmfXgfJ0agDpPA7oV89g" secondNeighbor="iaAT-1dG0USXIQUM5EweVw">
+      <NeighborhoodBuilder id="9kSshIS3KEq_sXt6ll6BWA" name="Lumen_colasc_ColonAscendens_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="B6U75mASo02V01eMygYROA" secondNeighbor="WLbI5Rdu60Wk9X8eKNb3tg">
         <Tags>
-          <Tag value="Neighborhood: ColonDescendens / Intracellular" />
+          <Tag value="Neighborhood: ColonAscendens / Intracellular" />
         </Tags>
         <Children>
-          <Container id="Z-7XbRof5U2TU8OJGftSsA" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="a7Qh9BFDmEihC9Yp1tDuzQ" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="hg_ukGWvV0am7a_Z-vKZRA" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K3" isDefault="1">
-                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              <Parameter id="xX2GnOJZZU6-MYFnczS78A" name="Drug absorption rate (lumen to mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_DrugAbsorption_trans" isDefault="1" displayUnit="µmol/min">
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
               </Parameter>
-              <Parameter id="KTTUaiHamUqhLPseU2miJA" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K4" isDefault="1">
+              <Parameter id="RMjf-gtz_UK_RapRapiTDw" name="P_int_trans_cell_lum_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_cell_lum_factor" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="RbDRgNTG00-l2JSgz2JF1A" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K5" isDefault="1">
+              <Parameter id="DyP0EA2MWkuMa7H_sqjOiA" name="P_int_trans_lum_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_lum_cell_factor" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="L_1EAIAd9Eehxhv9cEzSvg" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K6" isDefault="1">
-                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              <Parameter id="uslGWqQjfkaSWq7wEJL2XA" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_K_cell_pls_ColonAscendens" isDefault="1">
+                <Info min="0" flag="36" seq="1" ref="0" bb="2" group="67" />
               </Parameter>
-              <Parameter id="5vsV3O2bjkiSnn5X2NsXDQ" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K7" isDefault="1">
-                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              <Parameter id="9M1N2IzUn0SnoU004r_rAQ" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_ColonAscendens" isDefault="1">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
               </Parameter>
-              <Parameter id="evuzL-vHUk-gfu6yPUSqSA" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K8" isDefault="1">
+              <Parameter id="5jzKxidfckCwlpsd8q4jjw" name="pKa_pH_WS_cell_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F1" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="U9_uLX2xDUudydHDPoX5ow" name="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" isDefault="1" displayUnit="µmol/min">
-                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
-              </Parameter>
-              <Parameter id="WJstLrXBMUKWSeODl1VXuA" name="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" isDefault="1" displayUnit="µmol/min">
-                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
-              </Parameter>
-              <Parameter id="Q0chEFH5F0u8ghcoZjmrpw" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F3" isDefault="1">
+              <Parameter id="xG-rgFzxiUO6DQ57C-zwNA" name="pKa_pH_WS_cell_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F2" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="ulw0b8uaekmmgt4qtvEy2Q" name="pKa_pH_WS_cell_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F3" isDefault="1">
+              <Parameter id="bw0Whe6xGEKmrPmBrqDMYg" name="pKa_pH_WS_cell_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F3" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="SySiQmLylUejvBuCcso14g" name="Drug absorption rate (lumen to mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_DrugAbsorption_trans" isDefault="1" displayUnit="µmol/min">
-                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+              <Parameter id="VHSb4XNd0EqejfNVk4H-fg" name="pKa_pH_WS_cell_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K1" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="FgXWpp5SiEuF6iaxaLkk_A" name="P_int_trans_cell_lum_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_cell_lum_factor" isDefault="1">
+              <Parameter id="k4OYXPoSeEKT0VscrKfMCA" name="pKa_pH_WS_cell_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K2" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="inu5AEy08kuAKihRvdI8zQ" name="P_int_trans_lum_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_lum_cell_factor" isDefault="1">
+              <Parameter id="QcHLoDXXCEi71qEKzU_3Bg" name="pKa_pH_WS_cell_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K3" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="82O9Ht-9jUKrn_5i3p-GuQ" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_K_cell_pls_ColonDescendens" isDefault="1">
-                <Info min="0" flag="36" seq="1" ref="0" bb="2" group="67" />
+              <Parameter id="N6XMVnYlSESKfYZ5OEFJqA" name="pKa_pH_WS_cell_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K4" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="HCNmcZOJukCfl3yMkHhwXg" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_ColonDescendens" isDefault="1">
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+              <Parameter id="F5roj1TijkSPUDY1__nXxA" name="pKa_pH_WS_cell_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K5" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="EdAG4QT0Ckmt5uzQAQSoyg" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K2" isDefault="1">
+              <Parameter id="QegmHEamq0-1IApDs0fHGA" name="pKa_pH_WS_cell_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K6" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="AKt7HUNpR0ibc-mMAPtM6g" name="pKa_pH_WS_cell_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F2" isDefault="1">
+              <Parameter id="1qY71hzw7UepyHFJW8VJFg" name="pKa_pH_WS_cell_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K7" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="NJEMeMl-sU6wQ8xFbYJMKw" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K1" isDefault="1">
+              <Parameter id="sxeWw16Pfkauh2HwrRjVVA" name="pKa_pH_WS_cell_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K8" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="mFFzft-snkO9rQ14-vgddw" name="pKa_pH_WS_cell_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K1" isDefault="1">
+              <Parameter id="9x3tw3OM6EqstFVVsw_kvw" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F1" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="bY64C7J7wk-f4y9QJjn0Nw" name="pKa_pH_WS_cell_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K2" isDefault="1">
+              <Parameter id="z7IR68qxz0uhvOtJaOqJ_A" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F2" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="7pWlR_mqEUG1waLwvMkPyg" name="pKa_pH_WS_cell_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K3" isDefault="1">
+              <Parameter id="z8J9aRGY4UW-YRY4MQHdkg" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F3" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="EniThJcn8Uq2IWBrPFFGcw" name="pKa_pH_WS_cell_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K4" isDefault="1">
+              <Parameter id="kh_NzGBGwU-oGqVptUv6pg" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K1" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="xRzRWO37D0eoVUBHhPkqGg" name="pKa_pH_WS_cell_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K5" isDefault="1">
+              <Parameter id="dsnfjMIFFU2P1KeVZkFOBA" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K2" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="kL-32En8T0uQQ5CkdVK4ng" name="pKa_pH_WS_cell_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K6" isDefault="1">
+              <Parameter id="buyUNEa5iEyLB2_lD8eXSw" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K3" isDefault="1">
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               </Parameter>
-              <Parameter id="bLr1GaNqTUSw0Qte-wKdkg" name="pKa_pH_WS_cell_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K7" isDefault="1">
+              <Parameter id="WnZfHMdLIk66u-ZNWTH03w" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K4" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="_5N7nU3-o0e69XtmGl24UA" name="pKa_pH_WS_cell_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K8" isDefault="1">
+              <Parameter id="3atlLSu2NkWvvFwIHkD3JQ" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K5" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="z7IzhIf2S0iOMKiP4Px14g" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F1" isDefault="1">
+              <Parameter id="a-fcE_2iZUC20JWTYBNFDQ" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K6" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="tSEz-B2Gy0uIanCxUKs27w" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F2" isDefault="1">
+              <Parameter id="P5wdZKOdokOVaLdXEk3T3g" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K7" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="uDXD1dxa6kiiwy7Y2fDy4w" name="pKa_pH_WS_cell_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F1" isDefault="1">
+              <Parameter id="YJcgo-tlzECt4_GAwFyMqg" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K8" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
+              <Parameter id="RKuDpaW7FkmcHb-8daPiqg" name="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" isDefault="1" displayUnit="µmol/min">
+                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
+              <Parameter id="Y56SkAVfc0-hr7iB88PL9w" name="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" isDefault="1" displayUnit="µmol/min">
+                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
+            </Children>
+          </Container>
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="cWw1AUq8EEyiaBbGv3-A7A" name="ColonAscendens_pls_PortalVein_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="Enan29lQuku7kissDlHImQ" secondNeighbor="vihskj6fJkaqqVik0r1DIg">
+        <Tags>
+          <Tag value="Neighborhood: Plasma / Plasma" />
+        </Tags>
+        <Children>
+          <Container id="DGLKKQ3fWUyR0hv6oPpwkQ" name="MoleculeProperties" mode="Logical" containerType="Other">
+            <Children>
+              <Parameter id="fpJ7gtO-Uka0HwScms9zOg" name="Mass transfer rate (mucosa to portal vein plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPvePlasma" isDefault="1" displayUnit="µmol/min">
+                <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+              </Parameter>
             </Children>
           </Container>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="7e-EHSdltU2qIWtcX8-W4Q" name="Lumen_coldesc_ColonDescendens_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="JbHmfXgfJ0agDpPA7oV89g" secondNeighbor="IUx7uFw2hEyGTiqkSDgZaQ">
+      <NeighborhoodBuilder id="2jAGisgt9kKsrWbGrhDe1g" name="ColonAscendens_bc_PortalVein_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="Hoo2O0GaRU2870Bnck5hxw" secondNeighbor="eN7tQLMOREG3-_sYJSczng">
         <Tags>
-          <Tag value="Neighborhood: ColonDescendens / Plasma" />
+          <Tag value="Neighborhood: BloodCells / BloodCells" />
         </Tags>
         <Children>
-          <Container id="gRG0AQQlEEibHhBWDGLT0g" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="nJa-cfH7AkCEqJw_4xLtnw" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="BKjwkKmO1kGg7FstX5KBpQ" name="Drug absorption rate (lumen to mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_DrugAbsorption_para" isDefault="1" displayUnit="µmol/min">
+              <Parameter id="VXMywqwxoE-IW91UqG47gQ" name="Mass transfer rate (mucosa to portal vein blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPveBloodCells" isDefault="1" displayUnit="µmol/min">
+                <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                 <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
               </Parameter>
-              <Parameter id="anaaN_d0HkOSu9ZyUW3F_w" name="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" isDefault="1" displayUnit="µmol/min">
-                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
-              </Parameter>
-              <Parameter id="6AfiK7T0SUWWhX6EQU4jiA" name="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" isDefault="1" displayUnit="µmol/min">
-                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
-              </Parameter>
             </Children>
           </Container>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="7rzIPyJMu0eUHB6FClIpqA" name="ColonTransversum_bc_PortalVein_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="XD1QQa45SEaBqQBgPHhV4g" secondNeighbor="-ce4W1W9u0-sDuce1ufJ_A">
+      <NeighborhoodBuilder id="YpCESQk_LkeEoWkAlEXVng" name="Lumen_coltrans_ColonTransversum_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="azrzt6ezxUOsH5qwRQFgow" secondNeighbor="YYnhx2F-NU2lWPQmgq2Ulg">
         <Tags>
-          <Tag value="Neighborhood: BloodCells / BloodCells" />
+          <Tag value="Neighborhood: ColonTransversum / Plasma" />
         </Tags>
         <Children>
-          <Container id="AVURgFtVg020yRpU0Kg1tg" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="omk8QXqgVU67oVAHcbMrSg" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="YihOiDM_w0SHae5aPyABWw" name="Mass transfer rate (mucosa to portal vein blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPveBloodCells" isDefault="1" displayUnit="µmol/min">
-                <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+              <Parameter id="54753wyLZ0iyW5IlpqYuJQ" name="Drug absorption rate (lumen to mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_DrugAbsorption_para" isDefault="1" displayUnit="µmol/min">
                 <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
               </Parameter>
+              <Parameter id="VBe9hNtlyE2yGtNv2EEyzA" name="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" isDefault="1" displayUnit="µmol/min">
+                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
+              <Parameter id="LIH7Xt7Pi0Sv2p1JvnvsIw" name="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" isDefault="1" displayUnit="µmol/min">
+                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
             </Children>
           </Container>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="jZs6Z-w6JE6L1cdRNKA7Dw" name="Lumen_coltrans_ColonTransversum_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="ulKpUIAAi06wltlr56erzQ" secondNeighbor="Wr481BzF70KwAYQOaEn_ag">
+      <NeighborhoodBuilder id="kKnVx3DUMECtqnalQOp0_A" name="Lumen_coltrans_ColonTransversum_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="azrzt6ezxUOsH5qwRQFgow" secondNeighbor="1UgZYU8R5UWKEifrALKt2w">
         <Tags>
           <Tag value="Neighborhood: ColonTransversum / Intracellular" />
         </Tags>
         <Children>
-          <Container id="2RnX5dlv50SD7ogTGNdJ6w" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="yD57QAB5JEGhdYE1NMSpMA" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="5IcDlaXVckajW24Lkeoe1Q" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K2" isDefault="1">
+              <Parameter id="uikWzdGUO02KN_D4grv7Sw" name="Drug absorption rate (lumen to mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_DrugAbsorption_trans" isDefault="1" displayUnit="µmol/min">
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+              </Parameter>
+              <Parameter id="0mDfE--59EaT_vgY9WfGiA" name="P_int_trans_cell_lum_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_cell_lum_factor" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="oTWqAMClP0adB_fMBsheeA" name="pKa_pH_WS_cell_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K1" isDefault="1">
+              <Parameter id="-MyaGobG40yibXy-ZzKX3Q" name="P_int_trans_lum_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_lum_cell_factor" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="WKC_4_2DtUa3vbzVLF7nVg" name="pKa_pH_WS_cell_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K2" isDefault="1">
+              <Parameter id="CP_RwmL1hkqWRuzVeAcllQ" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_K_cell_pls_ColonTransversum" isDefault="1">
+                <Info min="0" flag="36" seq="1" ref="0" bb="2" group="67" />
+              </Parameter>
+              <Parameter id="_L383iSlLUGFgbmTddjP3Q" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_ColonTransversum" isDefault="1">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+              </Parameter>
+              <Parameter id="V50FDA-SvkWy6ersiCGL_g" name="pKa_pH_WS_cell_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F1" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="mdVyfuZjYkSqjmIG_YKyOQ" name="pKa_pH_WS_cell_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K3" isDefault="1">
+              <Parameter id="KL1RFxZMuEC11VLSXtO-IQ" name="pKa_pH_WS_cell_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F2" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="C5HoySduZk2knYMrVkGvjQ" name="pKa_pH_WS_cell_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K4" isDefault="1">
+              <Parameter id="58rL2zfc006haDatU3xRAQ" name="pKa_pH_WS_cell_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F3" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="KfawbN6CJE6K94PrK6SMtw" name="pKa_pH_WS_cell_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K5" isDefault="1">
+              <Parameter id="BQ-KYXKB3kyie0jS_rb1cQ" name="pKa_pH_WS_cell_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K1" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="CAMDnWmhO0iuzaPZ2wSuAg" name="pKa_pH_WS_cell_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K6" isDefault="1">
+              <Parameter id="sXqr39f-106qD-P8K8AmJg" name="pKa_pH_WS_cell_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K2" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="fbP55y0V80C9q5m3YdgkVA" name="pKa_pH_WS_cell_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K7" isDefault="1">
+              <Parameter id="BR7P79-EGEO5U5exD6V9QQ" name="pKa_pH_WS_cell_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K3" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="FiNMSJafH0SEFkvY9RBOkQ" name="pKa_pH_WS_cell_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K8" isDefault="1">
+              <Parameter id="bbyJthzwtUqxus5MBRtDaw" name="pKa_pH_WS_cell_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K4" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="2taPNNMPlEadlvDwG9A-2Q" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F1" isDefault="1">
+              <Parameter id="MfkSq_8R40Oh4j91Kty_ww" name="pKa_pH_WS_cell_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K5" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="WrzU-aBrHkWHyMKbFmbxmQ" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F2" isDefault="1">
+              <Parameter id="wNLUjobMJkGWMtTQpvhLKg" name="pKa_pH_WS_cell_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K6" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="fbC1QgfjoE6KKsO8d7Twjw" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K1" isDefault="1">
+              <Parameter id="goZWiKKtx06XwtqOW0kwRQ" name="pKa_pH_WS_cell_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K7" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="xkbtEiSLCECEKOG2jdPpXQ" name="pKa_pH_WS_cell_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F1" isDefault="1">
+              <Parameter id="6_io4Me-T0658wuALZWySg" name="pKa_pH_WS_cell_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K8" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="eFi-aUz5NkCQxII_PGDZbQ" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K3" isDefault="1">
+              <Parameter id="X_-jnOpFrUWEMe2HwKK3pQ" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F1" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="RicIpvV2F06HAuVG2YGa9w" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K4" isDefault="1">
+              <Parameter id="ZYNflB97d0SrhLDR4AOCTg" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F2" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="L8eFH4TPMkmXBBucxJL_Vg" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K5" isDefault="1">
+              <Parameter id="JZ1kvNmdyU-DTJJUkpE9gw" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F3" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="DCmu55jjjk21QDv2JcumnA" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K6" isDefault="1">
+              <Parameter id="auDAfd2wf0yQMp0KjCt3TQ" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K1" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="QfTI1TqR_EKqtbzw8jvPTg" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K7" isDefault="1">
+              <Parameter id="PoclrYUcBkKV244e8Rmu2w" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K2" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="UkpX-SQ0Lk6RSAAOtQnMiw" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K8" isDefault="1">
+              <Parameter id="fJWpkXfKJUKAJGmsKwDNeg" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K3" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="5ACIjx7mTEmaecQNaMrM7A" name="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" isDefault="1" displayUnit="µmol/min">
-                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+              <Parameter id="oWHB7lWLRkKqoqqXt8PC7g" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K4" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="ache_PEe8U-gXBWdy999sw" name="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" isDefault="1" displayUnit="µmol/min">
-                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+              <Parameter id="abmAm9SiS0SGW4pGmonyDQ" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K5" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="lXEi68Y5N0S06jVlnMrgNA" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F3" isDefault="1">
+              <Parameter id="9qalaKzhgke0icmkrUJa9g" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K6" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="h-a4fYE2K0u5Xr5QeYTJow" name="pKa_pH_WS_cell_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F3" isDefault="1">
+              <Parameter id="k42ftF9e6kySig0HXOuflw" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K7" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="yVvNGTeufEKTshLwEDT63Q" name="pKa_pH_WS_cell_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F2" isDefault="1">
+              <Parameter id="Jdarcrqh00KikDISoUVIkg" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K8" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="tELXFGpebkCSqJutblGMOw" name="Drug absorption rate (lumen to mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_DrugAbsorption_trans" isDefault="1" displayUnit="µmol/min">
+              <Parameter id="nmD8AAu8nkmuCwe3i6tC3A" name="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" isDefault="1" displayUnit="µmol/min">
+                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
+              <Parameter id="iVJqtMMylUuPF6NxtEAmUA" name="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" isDefault="1" displayUnit="µmol/min">
+                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
+            </Children>
+          </Container>
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="WHXMDGTuPEGu76uEcIyUQQ" name="ColonTransversum_pls_PortalVein_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="YYnhx2F-NU2lWPQmgq2Ulg" secondNeighbor="vihskj6fJkaqqVik0r1DIg">
+        <Tags>
+          <Tag value="Neighborhood: Plasma / Plasma" />
+        </Tags>
+        <Children>
+          <Container id="0lyOXATvYESEeKOmLiYJ6Q" name="MoleculeProperties" mode="Logical" containerType="Other">
+            <Children>
+              <Parameter id="4ZpSE4mlY0GnNyJQt-LhsQ" name="Mass transfer rate (mucosa to portal vein plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPvePlasma" isDefault="1" displayUnit="µmol/min">
+                <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                 <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
               </Parameter>
-              <Parameter id="gD6kYEQSNEKylcnP_-hW8w" name="P_int_trans_cell_lum_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_cell_lum_factor" isDefault="1">
-                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+            </Children>
+          </Container>
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="mKxgZbWYdEWUvA3jMMfemQ" name="ColonTransversum_bc_PortalVein_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="osnPctKJG0u6adLxRN6NBg" secondNeighbor="eN7tQLMOREG3-_sYJSczng">
+        <Tags>
+          <Tag value="Neighborhood: BloodCells / BloodCells" />
+        </Tags>
+        <Children>
+          <Container id="TGIhpxp0KEqvCTeybEKwgg" name="MoleculeProperties" mode="Logical" containerType="Other">
+            <Children>
+              <Parameter id="Q9dHgbC4Y0iIMZhoFq4HLg" name="Mass transfer rate (mucosa to portal vein blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPveBloodCells" isDefault="1" displayUnit="µmol/min">
+                <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
               </Parameter>
-              <Parameter id="6lXoZtERMEWVkFjPQnqhLw" name="P_int_trans_lum_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_lum_cell_factor" isDefault="1">
-                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+            </Children>
+          </Container>
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="UNjDHXzrJUeiyVmdRmFqjQ" name="Lumen_coldesc_ColonDescendens_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="PIYPudRTc0ObXI5ZSrWFNg" secondNeighbor="7yM-io-zfEuH_h7HbN-j3Q">
+        <Tags>
+          <Tag value="Neighborhood: ColonDescendens / Plasma" />
+        </Tags>
+        <Children>
+          <Container id="Cl4xK448ak2vMllP7v4OBA" name="MoleculeProperties" mode="Logical" containerType="Other">
+            <Children>
+              <Parameter id="g9GqUs2OXUuhxLryFLPbmw" name="Drug absorption rate (lumen to mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_DrugAbsorption_para" isDefault="1" displayUnit="µmol/min">
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
               </Parameter>
-              <Parameter id="PMCehVQQ5k6xNIyUkQzY-Q" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_K_cell_pls_ColonTransversum" isDefault="1">
-                <Info min="0" flag="36" seq="1" ref="0" bb="2" group="67" />
+              <Parameter id="UIAWsAXsMEet0i7JGREVZw" name="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" isDefault="1" displayUnit="µmol/min">
+                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
               </Parameter>
-              <Parameter id="ThMJzP1NL0iyor3rulRJ9g" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_ColonTransversum" isDefault="1">
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+              <Parameter id="LJEV6Ir95kiG_V-YmIJlBA" name="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" isDefault="1" displayUnit="µmol/min">
+                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
               </Parameter>
             </Children>
           </Container>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="RkPR7tSZ7kOGyrRpElFFoQ" name="Lumen_colsigm_ColonSigmoid_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="IUIlF5c6mEeLyH0-jGRL5g" secondNeighbor="-UolCvDsZkqBk6uvEQwkyg">
+      <NeighborhoodBuilder id="_LvAOHAkI0iagnAXVyJPYg" name="Lumen_coldesc_ColonDescendens_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="PIYPudRTc0ObXI5ZSrWFNg" secondNeighbor="lB3zaDNmVkWiBvM88nUHOw">
         <Tags>
-          <Tag value="Neighborhood: ColonSigmoid / Intracellular" />
+          <Tag value="Neighborhood: ColonDescendens / Intracellular" />
         </Tags>
         <Children>
-          <Container id="DJVdvXls-UOyIFyxWltquw" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="Q1GXuiTTQ02AcyROTfEFfA" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="K5JNcKOcBka_5KA1tWUzfA" name="Drug absorption rate (lumen to mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_DrugAbsorption_trans" isDefault="1" displayUnit="µmol/min">
+              <Parameter id="0wwbwNkX9kSvCKbLdO6RFQ" name="Drug absorption rate (lumen to mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_DrugAbsorption_trans" isDefault="1" displayUnit="µmol/min">
                 <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
               </Parameter>
-              <Parameter id="LpkGLLHYrUiezhZJmyeEhA" name="P_int_trans_cell_lum_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_cell_lum_factor" isDefault="1">
+              <Parameter id="uXOehr0E7Eyz65LP2NrufQ" name="P_int_trans_cell_lum_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_cell_lum_factor" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="H-hrA2P2SE-yobWa-RskPA" name="P_int_trans_lum_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_lum_cell_factor" isDefault="1">
+              <Parameter id="rDh2EUSalke9rqZUgJwzGQ" name="P_int_trans_lum_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_lum_cell_factor" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="7FzPjpb8gEO4yNBJzmsylw" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_K_cell_pls_ColonSigmoid" isDefault="1">
+              <Parameter id="rdlatcmbmEWQcUJMquOj5g" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_K_cell_pls_ColonDescendens" isDefault="1">
                 <Info min="0" flag="36" seq="1" ref="0" bb="2" group="67" />
               </Parameter>
-              <Parameter id="bVm2HeGveU-WKfKkUkRsOA" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_ColonSigmoid" isDefault="1">
+              <Parameter id="NzQ2XSdiYUe8H2CIVz49aA" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_ColonDescendens" isDefault="1">
                 <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
               </Parameter>
-              <Parameter id="ETzLUVVO602cT2fswbgPfg" name="pKa_pH_WS_cell_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F3" isDefault="1">
+              <Parameter id="FXmg7L7tIEm0XQ0zDtyeJA" name="pKa_pH_WS_cell_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F1" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="TclVuIIbJUOjnWlsUNHNKQ" name="pKa_pH_WS_cell_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F1" isDefault="1">
+              <Parameter id="3mPmUGbwWEKrGEW4jHz1vQ" name="pKa_pH_WS_cell_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F2" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="X8PBEHEjSEOEAizyxzcYJg" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K2" isDefault="1">
+              <Parameter id="2JZBEOY7AE-Afs3IsCDY9A" name="pKa_pH_WS_cell_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F3" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="Dp90XkVLe02OQGMvfRGhvQ" name="pKa_pH_WS_cell_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K1" isDefault="1">
+              <Parameter id="Q9W1L4VTDkmx7YWsKRG7DQ" name="pKa_pH_WS_cell_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K1" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="cx2cgGDObkuTkzBCv2TqfQ" name="pKa_pH_WS_cell_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K2" isDefault="1">
+              <Parameter id="nYElyB2UwEeCj-0eG_qa6Q" name="pKa_pH_WS_cell_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K2" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="GO-MxHr5Z0ukCm3C638OYw" name="pKa_pH_WS_cell_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K3" isDefault="1">
+              <Parameter id="qaPyxP7yrUeSajWliKcVng" name="pKa_pH_WS_cell_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K3" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="vn5NvRu0tEu43A0FmubK3Q" name="pKa_pH_WS_cell_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K4" isDefault="1">
+              <Parameter id="4vlmlIN3ekGTFHagRl2N-w" name="pKa_pH_WS_cell_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K4" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="Bsrm2GM-OkK28U19rjMvhw" name="pKa_pH_WS_cell_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K5" isDefault="1">
+              <Parameter id="JOGluhTwMEKqTW2cWhI1Cg" name="pKa_pH_WS_cell_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K5" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="YY0g42XE5Ey3_u6xoMyv6g" name="pKa_pH_WS_cell_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K6" isDefault="1">
+              <Parameter id="qOTLaHQxY0yTuX--axl7jA" name="pKa_pH_WS_cell_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K6" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="xKYVDfRzDUyw8BKXIWQ6mA" name="pKa_pH_WS_cell_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K7" isDefault="1">
+              <Parameter id="Pyk9I921rUOsq8CfRfW46Q" name="pKa_pH_WS_cell_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K7" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="_2G3nJwR5kSVAGvNBTk3Tw" name="pKa_pH_WS_cell_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K8" isDefault="1">
+              <Parameter id="OXat2EUXdECD1ITVQD3caQ" name="pKa_pH_WS_cell_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K8" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="CUUJLh1sgUK0PVDhsdi8Dw" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F1" isDefault="1">
+              <Parameter id="WA_q1b23VUKpRpNh5azieA" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F1" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="LzWxLRTLXUStMa3mbferbQ" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F2" isDefault="1">
+              <Parameter id="2fW0WL9Ob0GdfViTj_K0CA" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F2" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="9TeW4SgIt0CBYVUK8zr36Q" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K1" isDefault="1">
+              <Parameter id="-5m2hT6AjUK6XvGkaIsYLg" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F3" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="QuoaR-CAAkWSl6drZPKt1w" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K3" isDefault="1">
+              <Parameter id="7cFkzwIaJE-z5eBYVPg0UA" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K1" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="x0hap-7UTEeta7EtRuvp3Q" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K4" isDefault="1">
+              <Parameter id="3NwaXwnYH06xA8Fm9lDTIg" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K2" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="TomsATEAfEq4fx6U53m2TQ" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K5" isDefault="1">
+              <Parameter id="2uP4a_0mPk6J-pqX3lK-jA" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K3" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="elS1pUkcSk2QEgCTifsUng" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K6" isDefault="1">
+              <Parameter id="QLeBcokVvU-2MN10ub-8gQ" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K4" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="yYov-gL1RkKBHIAcZZWMKA" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K7" isDefault="1">
+              <Parameter id="wZP5pdiTFkSh4UYTRol58w" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K5" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="uEnAudoVgkS1YaKuQ0KyEg" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K8" isDefault="1">
+              <Parameter id="TpoG-WglF0yIdbhg1C4y7g" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K6" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="gGPY9ExWZk6TvMGp879AYQ" name="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" isDefault="1" displayUnit="µmol/min">
-                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
-              </Parameter>
-              <Parameter id="B2uHSh76CUW-bDeAr1Y0gA" name="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" isDefault="1" displayUnit="µmol/min">
-                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
-              </Parameter>
-              <Parameter id="2cbF0bjp502U46QQovxqiQ" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F3" isDefault="1">
+              <Parameter id="t3K66k9frE-0uMk39o_7OQ" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K7" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="UKeODh-CqkOWo90Xi5raUQ" name="pKa_pH_WS_cell_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F2" isDefault="1">
+              <Parameter id="NK4QIQp-PUKece5yd2uVgw" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K8" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
+              <Parameter id="n7EMAkVv1Eyt1NfysJJt3A" name="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" isDefault="1" displayUnit="µmol/min">
+                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
+              <Parameter id="j3CDuykT20a2oR0FijDB3g" name="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" isDefault="1" displayUnit="µmol/min">
+                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
             </Children>
           </Container>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="SFfrBVW8C02FUx2YGUFnQQ" name="ColonAscendens_bc_PortalVein_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="9KAYzyIOgUm0aPJQU3yU1A" secondNeighbor="-ce4W1W9u0-sDuce1ufJ_A">
+      <NeighborhoodBuilder id="Nee9SNxkM0qWJgysJyRVLA" name="ColonDescendens_pls_PortalVein_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="7yM-io-zfEuH_h7HbN-j3Q" secondNeighbor="vihskj6fJkaqqVik0r1DIg">
         <Tags>
-          <Tag value="Neighborhood: BloodCells / BloodCells" />
+          <Tag value="Neighborhood: Plasma / Plasma" />
         </Tags>
         <Children>
-          <Container id="50MZ0tBanUOrEsspc6Q7CA" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="4-uTtrWgzkWCmFq8SJk5KQ" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="xkUMskTeHkO4C2ykR-49XQ" name="Mass transfer rate (mucosa to portal vein blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPveBloodCells" isDefault="1" displayUnit="µmol/min">
+              <Parameter id="FVp1iwv8Jk2DNB0jCY05Eg" name="Mass transfer rate (mucosa to portal vein plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPvePlasma" isDefault="1" displayUnit="µmol/min">
                 <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                 <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
               </Parameter>
@@ -18600,14 +18808,14 @@
           </Container>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="QKl-Ib-_K06z-kIsiMf-Ow" name="ColonAscendens_pls_PortalVein_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="PlqyZ7UZA0CFE5wh4HT-4A" secondNeighbor="meWL4gPZR0uFouhVl8UsOw">
+      <NeighborhoodBuilder id="SE1h7RFVtkOLOVRzSNRUww" name="ColonDescendens_bc_PortalVein_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="Cl9Z1Ct4BEipGzx35zr3hA" secondNeighbor="eN7tQLMOREG3-_sYJSczng">
         <Tags>
-          <Tag value="Neighborhood: Plasma / Plasma" />
+          <Tag value="Neighborhood: BloodCells / BloodCells" />
         </Tags>
         <Children>
-          <Container id="mx-sEwQsBECAQCTcANujPA" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="DZw3GwF0O0O0jtEgrDUA3g" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="nlObVN7gCkSfJU0oWxA61Q" name="Mass transfer rate (mucosa to portal vein plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPvePlasma" isDefault="1" displayUnit="µmol/min">
+              <Parameter id="xaVdhbtJvEKX76kJtxnpLA" name="Mass transfer rate (mucosa to portal vein blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPveBloodCells" isDefault="1" displayUnit="µmol/min">
                 <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
                 <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
               </Parameter>
@@ -18615,147 +18823,132 @@
           </Container>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="TFhXW6FRTkOUhNkW2mVmSw" name="Lumen_colasc_ColonAscendens_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="ATNjWx7V7keoPmoUq2XmTQ" secondNeighbor="xgXczYdZrE692wGtlg0fgA">
+      <NeighborhoodBuilder id="lZJBE9zf9Uu0M_yYoiOZCw" name="Lumen_colsigm_ColonSigmoid_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="WT1bl4RAt0mxWQ1qvDeWTQ" secondNeighbor="4yj_1inZg0u37EViZ_d2aw">
         <Tags>
-          <Tag value="Neighborhood: ColonAscendens / Intracellular" />
+          <Tag value="Neighborhood: ColonSigmoid / Plasma" />
         </Tags>
         <Children>
-          <Container id="z3CMczeVXEmpnmIdkOwZrg" name="MoleculeProperties" mode="Logical" containerType="Other">
+          <Container id="YqjyVHNp70uPJjJbIXcyng" name="MoleculeProperties" mode="Logical" containerType="Other">
             <Children>
-              <Parameter id="ul0TbqPmlUG5Zgc3VLGo3w" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K3" isDefault="1">
-                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              <Parameter id="C-gzjxW4jEOPMgL0uXPq_A" name="Drug absorption rate (lumen to mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_DrugAbsorption_para" isDefault="1" displayUnit="µmol/min">
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
               </Parameter>
-              <Parameter id="ZrJI2_j61kqyXFCSdk_aBw" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K4" isDefault="1">
-                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              <Parameter id="pP_D3z9etkiJGCBnZRhRVg" name="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" isDefault="1" displayUnit="µmol/min">
+                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
               </Parameter>
-              <Parameter id="hydgexCRnk-TZR8emURPXw" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K5" isDefault="1">
-                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+              <Parameter id="GgnHOXkeb0yG7sAEfK7-lA" name="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" isDefault="1" displayUnit="µmol/min">
+                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
               </Parameter>
-              <Parameter id="-fdv3ltVtEmEue4cPVZf2Q" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K6" isDefault="1">
-                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+            </Children>
+          </Container>
+        </Children>
+      </NeighborhoodBuilder>
+      <NeighborhoodBuilder id="7gPXBfEQJ0GQOCe2fhgdTA" name="Lumen_colsigm_ColonSigmoid_cell" mode="Logical" containerType="Neighborhood" firstNeighbor="WT1bl4RAt0mxWQ1qvDeWTQ" secondNeighbor="tN9zkiBQG0CU40pBquto3w">
+        <Tags>
+          <Tag value="Neighborhood: ColonSigmoid / Intracellular" />
+        </Tags>
+        <Children>
+          <Container id="9MFzudDAFUmFRSHgS2Q5uQ" name="MoleculeProperties" mode="Logical" containerType="Other">
+            <Children>
+              <Parameter id="qur_m8Yet0q44thVf_ecaw" name="Drug absorption rate (lumen to mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_DrugAbsorption_trans" isDefault="1" displayUnit="µmol/min">
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
               </Parameter>
-              <Parameter id="wqCXauJdhkeH9zoyaaw89A" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K7" isDefault="1">
+              <Parameter id="njfJZ9lYMUavNlL6u9Bo3w" name="P_int_trans_cell_lum_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_cell_lum_factor" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="z2wfzLUR9k6r4ZFJ9qKg4w" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K8" isDefault="1">
+              <Parameter id="L0nhdQF_zEqAykiCgVQk_g" name="P_int_trans_lum_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_lum_cell_factor" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="YBRb-FhDdEGhdNhIYDTtaw" name="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" isDefault="1" displayUnit="µmol/min">
-                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+              <Parameter id="N-knLgUdp0-XtjgB03-k4g" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_K_cell_pls_ColonSigmoid" isDefault="1">
+                <Info min="0" flag="36" seq="1" ref="0" bb="2" group="67" />
               </Parameter>
-              <Parameter id="VYSaGlVpkECqBiRSXa_zaQ" name="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" isDefault="1" displayUnit="µmol/min">
-                <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+              <Parameter id="mbA4fZOUuE6ofF6e5_6k5w" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_ColonSigmoid" isDefault="1">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
               </Parameter>
-              <Parameter id="un_bzD5GO0-I0zFCIzsNWA" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F3" isDefault="1">
+              <Parameter id="vyK1ZLHk2EeVLaCYwmpxHg" name="pKa_pH_WS_cell_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F1" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="JHv6b2OstUyM6gZB0D_cgQ" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K2" isDefault="1">
+              <Parameter id="SBNlxAq0p0iKCO7djTqS1w" name="pKa_pH_WS_cell_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F2" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="2xoQBxjI40uMd7qUUe5gZw" name="pKa_pH_WS_cell_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F3" isDefault="1">
+              <Parameter id="iMep-SPQa0Wj0zfavF82Tw" name="pKa_pH_WS_cell_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F3" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="ku_Y5PSgRE-KGcsKqKJVtg" name="Drug absorption rate (lumen to mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_DrugAbsorption_trans" isDefault="1" displayUnit="µmol/min">
-                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+              <Parameter id="jgal9Ws9I0mg1PQ6HOTXLA" name="pKa_pH_WS_cell_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K1" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="HTwpKVc1c0GKy1oow4NJFQ" name="P_int_trans_cell_lum_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_cell_lum_factor" isDefault="1">
+              <Parameter id="6i1jCYLEkkmnKAGBhZGF0Q" name="pKa_pH_WS_cell_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K2" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="UfHpIFldzEKhMpFiQILU6Q" name="P_int_trans_lum_cell_factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_lum_cell_factor" isDefault="1">
+              <Parameter id="ivksETNHG02q5d8VR_voeA" name="pKa_pH_WS_cell_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K3" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="qc6bfAhN1keXonz25XQSrw" name="Partition coefficient (intracellular/plasma)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_K_cell_pls_ColonAscendens" isDefault="1">
-                <Info min="0" flag="36" seq="1" ref="0" bb="2" group="67" />
+              <Parameter id="9PUUDvrfK0aESt4C61VGIQ" name="pKa_pH_WS_cell_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K4" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="AERd7eIY8UiYqPMcmaAM2w" name="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_ColonAscendens" isDefault="1">
-                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+              <Parameter id="CHZqRfKo90aJKJuYMulS5A" name="pKa_pH_WS_cell_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K5" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="iYnxK871-UCd7NyrC_FSsA" name="pKa_pH_WS_cell_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F2" isDefault="1">
+              <Parameter id="BG1ot613W0GP3szhBV1Mlw" name="pKa_pH_WS_cell_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K6" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="-O4DmzXiIUO36Plm2dNJNg" name="pKa_pH_WS_cell_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K1" isDefault="1">
+              <Parameter id="HocQwf1jxEqaT1qDAniuVQ" name="pKa_pH_WS_cell_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K7" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="XlyES8GxqUeioannXTD9-w" name="pKa_pH_WS_cell_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K2" isDefault="1">
+              <Parameter id="7eWvSqG9tkS6O4hvm3vQkA" name="pKa_pH_WS_cell_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K8" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="7QUyu9ghdU-0QPsEtqiX3A" name="pKa_pH_WS_cell_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K3" isDefault="1">
+              <Parameter id="rdIGMAnD4k2PXE-0deyVkA" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F1" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="NMzLV2VhMUKtT5jrbc9u9Q" name="pKa_pH_WS_cell_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K4" isDefault="1">
+              <Parameter id="mEhtrHVdmkOt1_49kgQMcw" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F2" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="ikD2YU98VUm1yJKNQuKQHw" name="pKa_pH_WS_cell_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K5" isDefault="1">
+              <Parameter id="g_YDnBQJnEOwnfOpM5uf1g" name="pKa_pH_WS_lum_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F3" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="MrBXkpbYgkOnauL67vNvSA" name="pKa_pH_WS_cell_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K6" isDefault="1">
+              <Parameter id="bMPmEnQkJEepxo7HBd994g" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K1" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="Ief7uLJT4UWj41eRfA0Rvw" name="pKa_pH_WS_cell_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K7" isDefault="1">
+              <Parameter id="sT44yjiwCka6vARnmG3PsQ" name="pKa_pH_WS_lum_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K2" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="iacPA8tv6k6ZbnnTv4ZA5Q" name="pKa_pH_WS_cell_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K8" isDefault="1">
+              <Parameter id="UTpML9vS20yvDpXw5Db0-g" name="pKa_pH_WS_lum_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K3" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="kRfD8Np-UESlO8d8rBSvkQ" name="pKa_pH_WS_lum_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F1" isDefault="1">
+              <Parameter id="nkwA9Tz4gUC1Ku6I4Pbl9g" name="pKa_pH_WS_lum_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K4" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="aMsox-5EX0SMGBrdYNnwXg" name="pKa_pH_WS_lum_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F2" isDefault="1">
+              <Parameter id="LdhR0VH3g0yJHoBQl7tiBQ" name="pKa_pH_WS_lum_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K5" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="SBPPy57crEulRBJG86xhdA" name="pKa_pH_WS_cell_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F1" isDefault="1">
+              <Parameter id="8CoAkJZ2C0mwNj3oT3TpUw" name="pKa_pH_WS_lum_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K6" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="Wn5yWvk6tkCbwAcvqqDZ4Q" name="pKa_pH_WS_lum_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K1" isDefault="1">
+              <Parameter id="DOb23uoBIU6bc3DWY3jXUA" name="pKa_pH_WS_lum_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K7" isDefault="1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-            </Children>
-          </Container>
-        </Children>
-      </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="JOpv6A0AjUi-ZAMG8hPkVg" name="Lumen_colasc_ColonAscendens_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="ATNjWx7V7keoPmoUq2XmTQ" secondNeighbor="PlqyZ7UZA0CFE5wh4HT-4A">
-        <Tags>
-          <Tag value="Neighborhood: ColonAscendens / Plasma" />
-        </Tags>
-        <Children>
-          <Container id="2jTV-y86MEy9taj6s8BNmQ" name="MoleculeProperties" mode="Logical" containerType="Other">
-            <Children>
-              <Parameter id="yAjVOkb5QkiaNxaCbbUV6A" name="Drug absorption rate (lumen to mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Lumen_PKSim.PARAM_DrugAbsorption_para" isDefault="1" displayUnit="µmol/min">
-                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+              <Parameter id="s-S_gB3P40aRTTRZypA4gg" name="pKa_pH_WS_lum_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K8" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
               </Parameter>
-              <Parameter id="0qbrodve_0aekQQZhtrUBA" name="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" isDefault="1" displayUnit="µmol/min">
+              <Parameter id="Ei7LN8a2uEOx2nDaOi49IA" name="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" isDefault="1" displayUnit="µmol/min">
                 <Info flag="52" seq="1" ref="0" bb="2" group="117" />
               </Parameter>
-              <Parameter id="dMbqwHgfeE6L50LSXn1cfA" name="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" isDefault="1" displayUnit="µmol/min">
+              <Parameter id="CcHouyMTR0eAJwSnraYz2w" name="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" isDefault="1" displayUnit="µmol/min">
                 <Info flag="52" seq="1" ref="0" bb="2" group="117" />
               </Parameter>
             </Children>
           </Container>
         </Children>
       </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="_2m6xBeRXEmBA5vrbAiKCw" name="Caecum_bc_PortalVein_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="TZOfiNQfs0GwnASXrHgFkw" secondNeighbor="-ce4W1W9u0-sDuce1ufJ_A">
-        <Tags>
-          <Tag value="Neighborhood: BloodCells / BloodCells" />
-        </Tags>
-        <Children>
-          <Container id="ws0Mam6NY0arOFftH2lQWw" name="MoleculeProperties" mode="Logical" containerType="Other">
-            <Children>
-              <Parameter id="McprYg7wTEmoC_XgtpRCdA" name="Mass transfer rate (mucosa to portal vein blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPveBloodCells" isDefault="1" displayUnit="µmol/min">
-                <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
-                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
-              </Parameter>
-            </Children>
-          </Container>
-        </Children>
-      </NeighborhoodBuilder>
-      <NeighborhoodBuilder id="sOkJelPtSEaEWHsIgp1Kjg" name="Caecum_pls_PortalVein_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="LzJaekJVEUe4P9I9KnDGkQ" secondNeighbor="meWL4gPZR0uFouhVl8UsOw">
+      <NeighborhoodBuilder id="ViNrXwVaLUyH3lMAXnFuSg" name="ColonSigmoid_pls_PortalVein_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="4yj_1inZg0u37EViZ_d2aw" secondNeighbor="vihskj6fJkaqqVik0r1DIg">
         <Tags>
           <Tag value="Neighborhood: Plasma / Plasma" />
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         <Children>
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+      <NeighborhoodBuilder id="H1bwRssSLkyJ92PvOtfZkg" name="PortalVein_bc_Periportal_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="eN7tQLMOREG3-_sYJSczng" secondNeighbor="T23Nmml0lkOrwg34wc2z-g">
         <Tags>
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         </Tags>
         <Children>
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+          <Container id="PBTd2AmzXEqK-n_lkjbY6Q" name="MoleculeProperties" mode="Logical" containerType="Other" />
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+      <NeighborhoodBuilder id="OtA_b6BbQUOkN56gxDFIYQ" name="PortalVein_pls_Periportal_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="vihskj6fJkaqqVik0r1DIg" secondNeighbor="bo4cNXLni0i__twz_kf3zw">
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+          <Container id="oZEC4aI9RkuCNBIJNSshsw" name="MoleculeProperties" mode="Logical" containerType="Other" />
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+      <NeighborhoodBuilder id="oAKjUBA0TEquJV6PUBLB3Q" name="Periportal_bc_VenousBlood_bc" mode="Logical" containerType="Neighborhood" firstNeighbor="T23Nmml0lkOrwg34wc2z-g" secondNeighbor="bHtbzf2QTkS9BPP8ck7mNg">
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+          <Container id="2Pd1NMeJ5kmV1wEcqYTm4g" name="MoleculeProperties" mode="Logical" containerType="Other" />
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+      <NeighborhoodBuilder id="9E4v11xdH0awZlw2KgdjmA" name="Pericentral_cell_Gallbladder" mode="Logical" containerType="Neighborhood" firstNeighbor="mnTadGjxaEG5njWMX7v14A" secondNeighbor="wmf2zTyOt0m6vj1K0wTYqQ">
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+          <Container id="ifoQVLPP10q1scHE2khEMQ" name="MoleculeProperties" mode="Logical" containerType="Other" />
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+      <NeighborhoodBuilder id="qS6L0u3Gdk2W96rbLSb_2w" name="Periportal_cell_Gallbladder" mode="Logical" containerType="Neighborhood" firstNeighbor="MZ4yXcY8AEODi6dFenKSbA" secondNeighbor="wmf2zTyOt0m6vj1K0wTYqQ">
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+          <Container id="7oUG0LavuEiVwD9GwLetog" name="MoleculeProperties" mode="Logical" containerType="Other" />
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+      <NeighborhoodBuilder id="rurJA-_nbUSd7iTus05sfw" name="Pericentral_pls_VenousBlood_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="_pV4Se-Z9UWuyrB2KgwaBg" secondNeighbor="Ans5EKfuF0W1dnzkXjqTlg">
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+          <Container id="pRj8mKB75kKersQ-5gIPYg" name="MoleculeProperties" mode="Logical" containerType="Other" />
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+      <NeighborhoodBuilder id="LXkKu8PjrUKB8oWf2Zm8Mg" name="Periportal_pls_VenousBlood_pls" mode="Logical" containerType="Neighborhood" firstNeighbor="bo4cNXLni0i__twz_kf3zw" secondNeighbor="Ans5EKfuF0W1dnzkXjqTlg">
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-          <Container id="BZoMBN355EmTVicKEFvk4w" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="OhH5IZ5pWk6kpOjbY3Cc2Q" name="MoleculeProperties" mode="Logical" containerType="Other" />
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+      <NeighborhoodBuilder id="awHWSCV30k-UpkluhYlWYA" name="Pericentral_cell_Lumen_duo" mode="Logical" containerType="Neighborhood" firstNeighbor="mnTadGjxaEG5njWMX7v14A" secondNeighbor="1WeVhpyE0E2FsX9S1BNctw">
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+          <Container id="Ss2mJbrID0uHfkU4k5L3mg" name="MoleculeProperties" mode="Logical" containerType="Other" />
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+      <NeighborhoodBuilder id="pac3NUzUr0KsroOG6WcgsQ" name="Periportal_cell_Lumen_duo" mode="Logical" containerType="Neighborhood" firstNeighbor="MZ4yXcY8AEODi6dFenKSbA" secondNeighbor="1WeVhpyE0E2FsX9S1BNctw">
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-          <Container id="Qy-j9muLV0mEPBCxIshGJw" name="MoleculeProperties" mode="Logical" containerType="Other" />
+          <Container id="-mA3KUgeW0qW4hHez2tWpg" name="MoleculeProperties" mode="Logical" containerType="Other" />
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+      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_P_int" name="PARAM_P_int" dim="Velocity" formula="10 ^ (m * log10 (P_int_InVitro) + b)">
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-      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_P_int" name="PARAM_P_int" dim="Velocity" formula="10 ^ (m * log10 (P_int_InVitro) + b)">
+      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_MucosaPermeabilityScaleFactor_trans" name="PARAM_MucosaPermeabilityScaleFactor_trans" formula="P_int_trans_default &gt;0 ? P_int_trans / P_int_trans_default : 0">
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-          <Path path="9" as="10" />
-          <Path path="11" as="12" />
+          <Path path="12" as="13" />
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       <Formula id="DiffusionCommon_PKSim.PARAM_P_pls_rbc" name="PARAM_P_pls_rbc" dim="Velocity" formula="P * P_pls_rbc_factor">
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-          <Path path="7" as="8" dim="2" />
+          <Path path="14" as="15" dim="2" />
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+      <BlackBoxFormula id="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" name="CELLULAR PERMEABILITY FACTOR RATE" />
+      <BlackBoxFormula id="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" name="PARTITION COEFFICIENT FORMULA" />
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@@ -19146,54 +19219,46 @@
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+      <Formula id="Individual_PKSim.PARAM_CLSpec_endosomal_global" name="PARAM_CLSpec_endosomal_global" dim="Inversed time" formula="K_uptake-K_rec&gt;=0 ? K_uptake-K_rec : 0">
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-      <Formula id="Individual_PKSim.PARAM_CLSpec_endosomal_global" name="PARAM_CLSpec_endosomal_global" dim="Inversed time" formula="K_uptake-K_rec&gt;=0 ? K_uptake-K_rec : 0">
+      <Formula id="Individual_PKSim.PARAM_VolumePlasma" name="PARAM_VolumePlasma" dim="Volume" formula="V_pls_art+V_pls_bon+V_pls_brn+V_pls_cae+V_pls_colasc+V_pls_coldesc+V_pls_colsigm+V_pls_coltrans+V_pls_duo+V_pls_fat+V_pls_tes+V_pls_hrt+V_pls_kid+V_pls_lin+V_pls_lil+V_pls_lje+V_pls_lng+V_pls_mus+V_pls_pan+V_pls_prc+V_pls_prp+V_pls_pve+V_pls_rect+V_pls_skn+V_pls_sin+V_pls_spl+V_pls_sto+V_pls_uil+V_pls_uje+V_pls_ven">
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-          <Path path="112" as="113" dim="111" />
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+          <Path path="66" as="67" dim="55" />
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+          <Path path="70" as="71" dim="55" />
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+          <Path path="76" as="77" dim="55" />
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+          <Path path="80" as="81" dim="55" />
+          <Path path="82" as="83" dim="55" />
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+          <Path path="86" as="87" dim="55" />
+          <Path path="88" as="89" dim="55" />
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+          <Path path="92" as="93" dim="55" />
+          <Path path="94" as="95" dim="55" />
+          <Path path="96" as="97" dim="55" />
+          <Path path="98" as="99" dim="55" />
+          <Path path="100" as="101" dim="55" />
+          <Path path="102" as="103" dim="55" />
+          <Path path="104" as="105" dim="55" />
+          <Path path="106" as="107" dim="55" />
+          <Path path="108" as="109" dim="55" />
+          <Path path="110" as="111" dim="55" />
+          <Path path="112" as="113" dim="55" />
         </Paths>
       </Formula>
-      <SumFormula id="DynamicSumFormulas.PARAM_Tissue_Organs_Weight" name="PARAM_Tissue_Organs_Weight" dim="Mass" variable="P" formulaString="P_#i">
-        <Criteria>
-          <DescriptorConditions>
-            <MatchTagCondition tag="TissueOrgan" />
-            <MatchTagCondition tag="Weight (tissue)" />
-          </DescriptorConditions>
-        </Criteria>
-      </SumFormula>
       <Formula id="Individual_PKSim.PARAM_BW" name="PARAM_BW" dim="Mass" formula="Weight_blood + Weight_tissue">
         <Paths>
           <Path path="114" as="115" dim="116" />
@@ -19208,6 +19273,14 @@
           </DescriptorConditions>
         </Criteria>
       </SumFormula>
+      <SumFormula id="DynamicSumFormulas.PARAM_Tissue_Organs_Weight" name="PARAM_Tissue_Organs_Weight" dim="Mass" variable="P" formulaString="P_#i">
+        <Criteria>
+          <DescriptorConditions>
+            <MatchTagCondition tag="TissueOrgan" />
+            <MatchTagCondition tag="Weight (tissue)" />
+          </DescriptorConditions>
+        </Criteria>
+      </SumFormula>
       <Formula id="GFR_Calculation.PARAM_PostMenstrualAge" name="PARAM_PostMenstrualAge" dim="Age in weeks" formula="Age* 365.25/7 + GA">
         <Paths>
           <Path path="119" as="120" dim="121" />
@@ -19229,18 +19302,18 @@
       <Formula id="Individual_PKSim.PARAM_Tissue_Weight" name="PARAM_Tissue_Weight" dim="Mass" formula="Volume * Density">
         <Paths>
           <Path path="132" as="133" dim="133" />
-          <Path path="134" as="50" dim="50" />
+          <Path path="134" as="55" dim="55" />
         </Paths>
       </Formula>
       <Formula id="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" name="PARAM_ProteinContainerVolume_Compartment" dim="Volume" formula="Volume">
         <Paths>
-          <Path path="134" as="50" dim="50" />
+          <Path path="134" as="55" dim="55" />
         </Paths>
       </Formula>
       <Formula id="CompartmentsVolume_4Comp.VOLUME_pls_BloodOrgan_4Comp" name="VOLUME_pls_BloodOrgan_4Comp" dim="Volume" formula="(1-HCT)*V">
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           <Path path="135" as="136" />
-          <Path path="137" as="138" dim="50" />
+          <Path path="137" as="138" dim="55" />
           <Path path="40" as="41" />
         </Paths>
       </Formula>
@@ -19261,7 +19334,7 @@
       </Formula>
       <Formula id="CompartmentsVolume_4Comp.VOLUME_bc_blood_organ_4comp" name="VOLUME_bc_blood_organ_4comp" dim="Volume" formula="HCT*V">
         <Paths>
-          <Path path="137" as="138" dim="50" />
+          <Path path="137" as="138" dim="55" />
           <Path path="40" as="41" />
         </Paths>
       </Formula>
@@ -19271,197 +19344,197 @@
           <Path path="144" as="145" />
         </Paths>
       </Formula>
-      <Formula id="Individual_PKSim.PARAM_GallbladderRefillTime" name="PARAM_GallbladderRefillTime" dim="Time" formula="6*EHC_HalfTime">
-        <Paths>
-          <Path path="146" as="147" dim="143" />
-          <TimePath />
-        </Paths>
-      </Formula>
       <Formula id="Individual_PKSim.PARAM_Q_from_Qspec" name="PARAM_Q_from_Qspec" dim="Flow" formula="Qspec * Weight">
         <Paths>
-          <Path path="148" as="149" dim="150" />
-          <Path path="151" as="152" dim="116" />
+          <Path path="146" as="147" dim="148" />
+          <Path path="149" as="150" dim="116" />
         </Paths>
       </Formula>
       <Formula id="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate" name="PARAM_Fluid_recirculation_flow_rate" dim="Flow" formula="f_Jiso * (1-alpha_l) * Q_lymph * (V/V_mouse)^(exp_Jiso_scale - 1)">
         <Paths>
+          <Path path="151" as="152" />
           <Path path="153" as="154" />
-          <Path path="155" as="156" />
-          <Path path="157" as="158" dim="159" />
-          <Path path="160" as="161" dim="50" />
-          <Path path="134" as="138" dim="50" />
-          <Path path="162" as="163" />
+          <Path path="155" as="156" dim="157" />
+          <Path path="158" as="159" dim="55" />
+          <Path path="134" as="138" dim="55" />
+          <Path path="160" as="161" />
         </Paths>
       </Formula>
       <Formula id="Individual_PKSim.PARAM_Lymph_flow_rate" name="PARAM_Lymph_flow_rate" dim="Flow" formula="f_lymph*Q*(1-HCT)">
         <Paths>
-          <Path path="164" as="165" dim="159" />
-          <Path path="166" as="167" />
+          <Path path="162" as="163" dim="157" />
+          <Path path="164" as="165" />
           <Path path="40" as="41" />
         </Paths>
       </Formula>
       <Formula id="VascularEndoVolume.VOLUME_VascularEndo_bon" name="VOLUME_VascularEndo_bon" dim="Volume" formula="SA_pls_int*d_endo">
         <Paths>
-          <Path path="168" as="169" dim="127" />
-          <Path path="170" as="171" dim="172" />
+          <Path path="166" as="167" dim="127" />
+          <Path path="168" as="169" dim="170" />
         </Paths>
       </Formula>
       <Formula id="Individual_PKSim.PARAM_f_cell" name="PARAM_f_cell" formula="1 - f_int - f_vas">
         <Paths>
-          <Path path="173" as="174" />
-          <Path path="175" as="136" />
+          <Path path="171" as="172" />
+          <Path path="173" as="136" />
         </Paths>
       </Formula>
       <Formula id="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" name="VOLUME_pls_4Comp" dim="Volume" formula="f_vas*(1-HCT)*V_org">
         <Paths>
           <Path path="135" as="136" />
-          <Path path="137" as="176" dim="50" />
+          <Path path="137" as="174" dim="55" />
           <Path path="40" as="41" />
         </Paths>
       </Formula>
       <Formula id="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" name="VOLUME_bc_4Comp" dim="Volume" formula="f_vas*HCT*V">
         <Paths>
           <Path path="135" as="136" />
-          <Path path="137" as="138" dim="50" />
+          <Path path="137" as="138" dim="55" />
           <Path path="40" as="41" />
         </Paths>
       </Formula>
       <Formula id="CompartmentsVolume_4Comp.VOLUME_int_4Comp" name="VOLUME_int_4Comp" dim="Volume" formula="f_int*V">
         <Paths>
-          <Path path="177" as="174" />
-          <Path path="137" as="138" dim="50" />
+          <Path path="175" as="172" />
+          <Path path="137" as="138" dim="55" />
         </Paths>
       </Formula>
       <Formula id="Individual_PKSim.PARAM_pH_INT" name="PARAM_pH_INT" formula="pH_int">
         <Paths>
-          <Path path="178" as="179" />
+          <Path path="176" as="177" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_bon" name="PARAM_K_Water_INT_bon" formula="K_water_int">
         <Paths>
-          <Path path="180" as="181" />
+          <Path path="178" as="179" />
         </Paths>
       </Formula>
       <Formula id="CompoundCommon.PARAM_ProteinContainerVolume_Organ" name="PARAM_ProteinContainerVolume_Organ" dim="Volume" formula="Volume">
         <Paths>
-          <Path path="137" as="50" dim="50" />
+          <Path path="137" as="55" dim="55" />
         </Paths>
       </Formula>
       <Formula id="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" name="VOLUME_cell_4Comp" dim="Volume" formula="f_cell*V">
         <Paths>
-          <Path path="182" as="183" />
-          <Path path="137" as="138" dim="50" />
+          <Path path="180" as="181" />
+          <Path path="137" as="138" dim="55" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_bon" name="PARAM_K_Water_CELL_bon" formula="K_water_cell">
         <Paths>
-          <Path path="184" as="185" />
+          <Path path="182" as="183" />
+        </Paths>
+      </Formula>
+      <Formula id="Individual_PKSim.PARAM_GallbladderRefillTime" name="PARAM_GallbladderRefillTime" dim="Time" formula="6*EHC_HalfTime">
+        <Paths>
+          <Path path="184" as="185" dim="143" />
+          <TimePath />
         </Paths>
       </Formula>
       <Formula id="VascularEndoVolume.VOLUME_VascularEndo_brn" name="VOLUME_VascularEndo_brn" dim="Volume" formula="SA_pls_int*d_endo">
         <Paths>
-          <Path path="168" as="169" dim="127" />
-          <Path path="186" as="171" dim="172" />
+          <Path path="166" as="167" dim="127" />
+          <Path path="186" as="169" dim="170" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_brn" name="PARAM_K_Water_INT_brn" formula="K_water_int">
         <Paths>
-          <Path path="187" as="181" />
+          <Path path="187" as="179" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_brn" name="PARAM_K_Water_CELL_brn" formula="K_water_cell">
         <Paths>
-          <Path path="188" as="185" />
+          <Path path="188" as="183" />
         </Paths>
       </Formula>
       <Formula id="VascularEndoVolume.VOLUME_VascularEndo_fat" name="VOLUME_VascularEndo_fat" dim="Volume" formula="SA_pls_int*d_endo">
         <Paths>
-          <Path path="168" as="169" dim="127" />
-          <Path path="189" as="171" dim="172" />
+          <Path path="166" as="167" dim="127" />
+          <Path path="189" as="169" dim="170" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_fat" name="PARAM_K_Water_INT_fat" formula="K_water_int">
         <Paths>
-          <Path path="190" as="181" />
+          <Path path="190" as="179" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_fat" name="PARAM_K_Water_CELL_fat" formula="K_water_cell">
         <Paths>
-          <Path path="191" as="185" />
+          <Path path="191" as="183" />
         </Paths>
       </Formula>
       <Formula id="VascularEndoVolume.VOLUME_VascularEndo_tes" name="VOLUME_VascularEndo_tes" dim="Volume" formula="SA_pls_int*d_endo">
         <Paths>
-          <Path path="168" as="169" dim="127" />
-          <Path path="192" as="171" dim="172" />
+          <Path path="166" as="167" dim="127" />
+          <Path path="192" as="169" dim="170" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_tes" name="PARAM_K_Water_INT_tes" formula="K_water_int">
         <Paths>
-          <Path path="193" as="181" />
+          <Path path="193" as="179" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_tes" name="PARAM_K_Water_CELL_tes" formula="K_water_cell">
         <Paths>
-          <Path path="194" as="185" />
+          <Path path="194" as="183" />
         </Paths>
       </Formula>
       <Formula id="VascularEndoVolume.VOLUME_VascularEndo_hrt" name="VOLUME_VascularEndo_hrt" dim="Volume" formula="SA_pls_int*d_endo">
         <Paths>
-          <Path path="168" as="169" dim="127" />
-          <Path path="195" as="171" dim="172" />
+          <Path path="166" as="167" dim="127" />
+          <Path path="195" as="169" dim="170" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_hrt" name="PARAM_K_Water_INT_hrt" formula="K_water_int">
         <Paths>
-          <Path path="196" as="181" />
+          <Path path="196" as="179" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_hrt" name="PARAM_K_Water_CELL_hrt" formula="K_water_cell">
         <Paths>
-          <Path path="197" as="185" />
+          <Path path="197" as="183" />
         </Paths>
       </Formula>
       <Formula id="VascularEndoVolume.VOLUME_VascularEndo_kid" name="VOLUME_VascularEndo_kid" dim="Volume" formula="SA_pls_int*d_endo">
         <Paths>
-          <Path path="168" as="169" dim="127" />
-          <Path path="198" as="171" dim="172" />
+          <Path path="166" as="167" dim="127" />
+          <Path path="198" as="169" dim="170" />
         </Paths>
       </Formula>
-      <Formula id="Renal_Aging_Human.Renal aging factor" name="Renal aging factor" formula="Age &lt;= Age_onset ? 1 : 1 - Decrease_Factor*(Age-Age_onset)^Hill/(TA50^Hill+(Age-Age_onset)^Hill)">
+      <Formula id="GFR_Calculation.PARAM_GFR" name="PARAM_GFR" dim="Flow" formula="GFRspec * Weight_Kidney">
         <Paths>
-          <Path path="199" as="120" dim="121" />
-          <Path path="200" as="201" dim="121" />
-          <Path path="202" as="203" dim="121" />
-          <Path path="204" as="205" />
-          <Path path="206" as="207" />
+          <Path path="199" as="200" dim="148" />
+          <Path path="201" as="202" dim="116" />
         </Paths>
       </Formula>
-      <Formula id="GFR_Calculation.PARAM_GFR" name="PARAM_GFR" dim="Flow" formula="GFRspec * Weight_Kidney">
+      <Formula id="GFR_Calculation.PARAM_GFR_Spec" name="PARAM_GFR_Spec" dim="Flow per weight organ" formula="(PMA^Hill/(TM50^Hill+PMA^Hill)*(1-GFR_premat)+GFR_premat) * GFR_mat / V_kid_std * Renal_aging_scaling_factor">
         <Paths>
-          <Path path="208" as="209" dim="150" />
-          <Path path="210" as="211" dim="116" />
+          <Path path="203" as="204" dim="124" />
+          <Path path="205" as="206" dim="157" />
+          <Path path="207" as="208" />
+          <Path path="209" as="210" />
+          <Path path="211" as="212" dim="124" />
+          <Path path="213" as="214" dim="55" />
+          <Path path="215" as="216" />
         </Paths>
       </Formula>
-      <Formula id="GFR_Calculation.PARAM_GFR_Spec" name="PARAM_GFR_Spec" dim="Flow per weight organ" formula="(PMA^Hill/(TM50^Hill+PMA^Hill)*(1-GFR_premat)+GFR_premat) * GFR_mat / V_kid_std * Renal_aging_scaling_factor">
+      <Formula id="Renal_Aging_Human.Renal aging factor" name="Renal aging factor" formula="Age &lt;= Age_onset ? 1 : 1 - Decrease_Factor*(Age-Age_onset)^Hill/(TA50^Hill+(Age-Age_onset)^Hill)">
         <Paths>
-          <Path path="212" as="213" dim="124" />
-          <Path path="214" as="215" />
-          <Path path="216" as="217" dim="159" />
-          <Path path="218" as="205" />
-          <Path path="219" as="220" />
-          <Path path="221" as="222" dim="124" />
-          <Path path="223" as="224" dim="50" />
+          <Path path="217" as="120" dim="121" />
+          <Path path="218" as="219" dim="121" />
+          <Path path="220" as="221" dim="121" />
+          <Path path="222" as="208" />
+          <Path path="223" as="224" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_kid" name="PARAM_K_Water_INT_kid" formula="K_water_int">
         <Paths>
-          <Path path="225" as="181" />
+          <Path path="225" as="179" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_kid" name="PARAM_K_Water_CELL_kid" formula="K_water_cell">
         <Paths>
-          <Path path="226" as="185" />
+          <Path path="226" as="183" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_FillLevelFlagFlag" name="PARAM_FillLevelFlagFlag" formula="(FillLevel&lt;0.9?1:1/(1+exp((FillLevel-1)/0.01)))">
@@ -19471,8 +19544,8 @@
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_FillLevel" name="PARAM_FillLevel" formula="Liquid/V">
         <Paths>
-          <Path path="229" as="230" dim="50" />
-          <Path path="134" as="138" dim="50" />
+          <Path path="229" as="230" dim="55" />
+          <Path path="134" as="138" dim="55" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_Area" name="PARAM_Area" dim="Area" formula="PI*(r1+r2)*L">
@@ -19490,29 +19563,34 @@
       <Formula id="Lumen_PKSim.PARAM_Liquid_StartValue" name="PARAM_Liquid_StartValue" dim="Volume" formula="V*SteadyStateFillLevel">
         <Paths>
           <Path path="239" as="240" dim="24" />
-          <Path path="134" as="138" dim="50" />
+          <Path path="134" as="138" dim="55" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.LiquidRHS_sto" name="LiquidRHS_sto" dim="Flow" formula="OralApplicationsEnabled ? -LT_sto + Inflow*FillLevelFlag : 0">
         <Paths>
           <Path path="241" as="242" />
-          <Path path="243" as="244" dim="159" />
-          <Path path="245" as="246" dim="159" />
+          <Path path="243" as="244" dim="157" />
+          <Path path="245" as="246" dim="157" />
           <Path path="247" as="248" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_LiquidTransferRate_sto" name="PARAM_LiquidTransferRate_sto" dim="Flow" formula="w*Liquid*FillLevelFlagNext">
         <Paths>
-          <Path path="249" as="250" dim="111" />
-          <Path path="229" as="230" dim="50" />
+          <Path path="249" as="250" dim="50" />
+          <Path path="229" as="230" dim="55" />
           <Path path="251" as="252" />
         </Paths>
       </Formula>
+      <Formula id="Lumen_PKSim.PARAM_pH_from_pH_fasted" name="PARAM_pH_from_pH_fasted" formula="pH_fasted">
+        <Paths>
+          <Path path="253" as="254" />
+        </Paths>
+      </Formula>
       <Formula id="Lumen_PKSim.PARAM_Inflow_Stomach" name="PARAM_Inflow_Stomach" dim="Flow" formula="SteadyStateFillLevel*V/StomachInflowTime">
         <Paths>
           <Path path="239" as="240" dim="24" />
-          <Path path="253" as="254" dim="143" />
-          <Path path="134" as="138" dim="50" />
+          <Path path="255" as="256" dim="143" />
+          <Path path="134" as="138" dim="55" />
           <TimePath />
         </Paths>
       </Formula>
@@ -19525,98 +19603,93 @@
       </Formula>
       <Formula id="MucosaVolume.PARAM_VolumeGutWall" name="PARAM_VolumeGutWall" dim="Volume" formula="Area*d">
         <Paths>
-          <Path path="255" as="172" dim="172" />
-          <Path path="256" as="257" dim="127" />
-        </Paths>
-      </Formula>
-      <Formula id="Lumen_PKSim.PARAM_pH_from_pH_fasted" name="PARAM_pH_from_pH_fasted" formula="pH_fasted">
-        <Paths>
-          <Path path="258" as="259" />
-        </Paths>
-      </Formula>
-      <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" name="PARAM_pKa_pH_WS_lum_ForSol_K1" formula="F1*F2*F3">
-        <Paths>
-          <Path path="260" as="261" />
-          <Path path="262" as="263" />
-          <Path path="264" as="265" />
+          <Path path="257" as="170" dim="170" />
+          <Path path="258" as="259" dim="127" />
         </Paths>
       </Formula>
       <Formula id="CompoundCommon.PARAM_OntogenyFactor_FromGlobal_GI" name="PARAM_OntogenyFactor_FromGlobal_GI" formula="f_onto">
         <Paths>
-          <Path path="266" as="140" />
+          <Path path="260" as="140" />
         </Paths>
       </Formula>
       <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" name="PARAM_pKa_pH_WS_lum_ForSol_F1" formula="CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1">
         <Paths>
+          <Path path="261" as="262" />
+          <Path path="263" as="264" />
+          <Path path="265" as="266" />
           <Path path="267" as="268" />
-          <Path path="269" as="270" />
-          <Path path="271" as="272" />
-          <Path path="273" as="274" />
         </Paths>
       </Formula>
       <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" name="PARAM_pKa_pH_WS_lum_ForSol_F2" formula="CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1">
         <Paths>
-          <Path path="275" as="276" />
+          <Path path="261" as="262" />
           <Path path="269" as="270" />
-          <Path path="277" as="278" />
-          <Path path="273" as="274" />
+          <Path path="271" as="272" />
+          <Path path="267" as="268" />
         </Paths>
       </Formula>
       <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" name="PARAM_pKa_pH_WS_lum_ForSol_F3" formula="CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1">
         <Paths>
+          <Path path="261" as="262" />
+          <Path path="273" as="274" />
+          <Path path="275" as="276" />
+          <Path path="267" as="268" />
+        </Paths>
+      </Formula>
+      <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" name="PARAM_pKa_pH_WS_lum_ForSol_K1" formula="F1*F2*F3">
+        <Paths>
+          <Path path="277" as="278" />
           <Path path="279" as="280" />
-          <Path path="269" as="270" />
           <Path path="281" as="282" />
-          <Path path="273" as="274" />
         </Paths>
       </Formula>
       <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" name="PARAM_pKa_pH_WS_lum_ForSol_K2" formula="(1-F1)*F2*F3">
         <Paths>
-          <Path path="260" as="261" />
-          <Path path="262" as="263" />
-          <Path path="264" as="265" />
+          <Path path="277" as="278" />
+          <Path path="279" as="280" />
+          <Path path="281" as="282" />
         </Paths>
       </Formula>
       <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" name="PARAM_pKa_pH_WS_lum_ForSol_K3" formula="F1*(1-F2)*F3">
         <Paths>
-          <Path path="260" as="261" />
-          <Path path="262" as="263" />
-          <Path path="264" as="265" />
+          <Path path="277" as="278" />
+          <Path path="279" as="280" />
+          <Path path="281" as="282" />
         </Paths>
       </Formula>
       <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" name="PARAM_pKa_pH_WS_lum_ForSol_K4" formula="F1*F2*(1-F3)">
         <Paths>
-          <Path path="260" as="261" />
-          <Path path="262" as="263" />
-          <Path path="264" as="265" />
+          <Path path="277" as="278" />
+          <Path path="279" as="280" />
+          <Path path="281" as="282" />
         </Paths>
       </Formula>
       <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" name="PARAM_pKa_pH_WS_lum_ForSol_K5" formula="(1-F1)*(1-F2)*F3">
         <Paths>
-          <Path path="260" as="261" />
-          <Path path="262" as="263" />
-          <Path path="264" as="265" />
+          <Path path="277" as="278" />
+          <Path path="279" as="280" />
+          <Path path="281" as="282" />
         </Paths>
       </Formula>
       <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" name="PARAM_pKa_pH_WS_lum_ForSol_K6" formula="(1-F1)*F2*(1-F3)">
         <Paths>
-          <Path path="260" as="261" />
-          <Path path="262" as="263" />
-          <Path path="264" as="265" />
+          <Path path="277" as="278" />
+          <Path path="279" as="280" />
+          <Path path="281" as="282" />
         </Paths>
       </Formula>
       <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" name="PARAM_pKa_pH_WS_lum_ForSol_K7" formula="F1*(1-F2)*(1-F3)">
         <Paths>
-          <Path path="260" as="261" />
-          <Path path="262" as="263" />
-          <Path path="264" as="265" />
+          <Path path="277" as="278" />
+          <Path path="279" as="280" />
+          <Path path="281" as="282" />
         </Paths>
       </Formula>
       <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" name="PARAM_pKa_pH_WS_lum_ForSol_K8" formula="(1-F1)*(1-F2)*(1-F3)">
         <Paths>
-          <Path path="260" as="261" />
-          <Path path="262" as="263" />
-          <Path path="264" as="265" />
+          <Path path="277" as="278" />
+          <Path path="279" as="280" />
+          <Path path="281" as="282" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_IntestinalSolubility" name="PARAM_IntestinalSolubility" dim="Concentration (mass)" formula="Solubility * Solubility_pKa_REFpH_Factor / Solubility_pKa_pH_Factor + SolubilityTable">
@@ -19630,7 +19703,7 @@
       <TableFormulaWithXArgument id="Lumen_PKSim.TableFormulaWithXArgument_SolubilityTable" name="TableFormulaWithXArgument_SolubilityTable" dim="Concentration (mass)" tableObjectAlias="Table" xArgumentAlias="XArg">
         <Paths>
           <Path path="292" as="293" dim="285" />
-          <Path path="273" as="294" />
+          <Path path="267" as="294" />
         </Paths>
       </TableFormulaWithXArgument>
       <Formula id="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" name="PARAM_Solubility_pKa_pH_Factor" formula="K1+K2/base^(CT0^2)+K3/base^(CT1^2)+K4/base^(CT2^2)+K5/base^max(CT0+CT1;-CT0-CT1)+K6/base^max(CT0+CT2;-CT0-CT2)+K7/base^max(CT1+CT2;-CT1-CT2)+K8/base^max(CT0+CT1+CT2;-CT0-CT1-CT2)">
@@ -19643,9 +19716,9 @@
           <Path path="305" as="306" />
           <Path path="307" as="308" />
           <Path path="309" as="310" />
-          <Path path="267" as="268" />
-          <Path path="275" as="276" />
-          <Path path="279" as="280" />
+          <Path path="263" as="264" />
+          <Path path="269" as="270" />
+          <Path path="273" as="274" />
           <Path path="311" as="312" />
         </Paths>
       </Formula>
@@ -19654,1404 +19727,1406 @@
           <Path path="313" as="142" dim="143" />
         </Paths>
       </Formula>
+      <Formula id="Lumen_PKSim.PARAM_EffectiveLumenConcentration" name="PARAM_EffectiveLumenConcentration" dim="Concentration (molar)" formula="EnableSupersaturarion ? M/Liquid : min(Solubility/MW ; M/Liquid)">
+        <Paths>
+          <Path path="314" as="315" dim="316" />
+          <Path path="317" as="289" dim="285" />
+          <Path path="318" as="319" />
+          <Path path="320" as="321" dim="322" />
+          <Path path="323" as="230" dim="55" />
+        </Paths>
+      </Formula>
+      <Formula id="Lumen_PKSim.PARAM_Outflow_Duodenum" name="PARAM_Outflow_Duodenum" dim="Inversed time" formula="(k_p*alpha_p*V_p+inflow-k*alpha*V)/(alpha*V)">
+        <Paths>
+          <Path path="239" as="324" dim="24" />
+          <Path path="249" as="325" dim="50" />
+          <Path path="245" as="326" dim="157" />
+          <Path path="134" as="138" dim="55" />
+          <Path path="327" as="328" dim="24" />
+          <Path path="329" as="330" dim="50" />
+          <Path path="331" as="332" dim="55" />
+        </Paths>
+      </Formula>
+      <Formula id="Lumen_Geometry.PARAM_Lumen_Geometry_R2" name="PARAM_Lumen_Geometry_R2" dim="Length" formula="r2_p0 + Height*r2_p1">
+        <Paths>
+          <Path path="333" as="126" dim="127" />
+          <Path path="334" as="335" dim="127" />
+          <Path path="336" as="337" />
+        </Paths>
+      </Formula>
+      <Formula id="Lumen_PKSim.PARAM_EffectiveSurfaceArea" name="PARAM_EffectiveSurfaceArea" dim="Area" formula="Ageom*AeffFactor*AeffVariabilityFactor">
+        <Paths>
+          <Path path="338" as="339" />
+          <Path path="257" as="340" dim="170" />
+          <Path path="341" as="342" />
+        </Paths>
+      </Formula>
       <Formula id="Lumen_PKSim.PARAM_InverseSITT_Factor_Duodenum" name="PARAM_InverseSITT_Factor_Duodenum" dim="Inversed time" formula="LuminalVelocity/SITT_fact">
         <Paths>
-          <Path path="314" as="315" dim="111" />
-          <Path path="316" as="317" />
+          <Path path="343" as="344" dim="50" />
+          <Path path="345" as="346" />
         </Paths>
       </Formula>
       <Formula id="Lumen_Geometry.PARAM_Lumen_Geometry_Length" name="PARAM_Lumen_Geometry_Length" dim="Length" formula="L_p0 + Height*L_p1">
         <Paths>
-          <Path path="318" as="126" dim="127" />
-          <Path path="319" as="320" dim="127" />
-          <Path path="321" as="322" />
+          <Path path="333" as="126" dim="127" />
+          <Path path="347" as="348" dim="127" />
+          <Path path="349" as="350" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.LiquidRHS_duo" name="LiquidRHS_duo" dim="Flow" formula="OralApplicationsEnabled ? LT_sto - LT_duo + Inflow*FillLevelFlag - Outflow*Liquid : 0">
         <Paths>
-          <Path path="323" as="324" dim="111" />
+          <Path path="351" as="352" dim="50" />
           <Path path="241" as="242" />
-          <Path path="229" as="230" dim="50" />
-          <Path path="243" as="325" dim="159" />
-          <Path path="245" as="246" dim="159" />
+          <Path path="229" as="230" dim="55" />
+          <Path path="243" as="353" dim="157" />
+          <Path path="245" as="246" dim="157" />
           <Path path="247" as="248" />
-          <Path path="326" as="244" dim="159" />
+          <Path path="354" as="244" dim="157" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_LiquidTransferRate_duo" name="PARAM_LiquidTransferRate_duo" dim="Flow" formula="w*Liquid*FillLevelFlagNext">
         <Paths>
-          <Path path="249" as="250" dim="111" />
-          <Path path="229" as="230" dim="50" />
-          <Path path="327" as="252" />
+          <Path path="249" as="250" dim="50" />
+          <Path path="229" as="230" dim="55" />
+          <Path path="355" as="252" />
         </Paths>
       </Formula>
       <Formula id="Lumen_Geometry.PARAM_Lumen_Geometry_R1" name="PARAM_Lumen_Geometry_R1" dim="Length" formula="r1_p0 + Height*r1_p1">
         <Paths>
-          <Path path="318" as="126" dim="127" />
-          <Path path="328" as="329" dim="127" />
-          <Path path="330" as="331" />
+          <Path path="333" as="126" dim="127" />
+          <Path path="356" as="357" dim="127" />
+          <Path path="358" as="359" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_Inflow_Duodenum" name="PARAM_Inflow_Duodenum" dim="Flow" formula="0.02894*V">
         <Paths>
-          <Path path="134" as="138" dim="50" />
+          <Path path="134" as="138" dim="55" />
         </Paths>
       </Formula>
       <Formula id="Lumen_Geometry.PARAM_Lumen_Geometry_Thickness" name="PARAM_Lumen_Geometry_Thickness" dim="Length" formula="Thickness_p1 + Thickness_p2*(1-exp(Thickness_p3*Height))">
         <Paths>
-          <Path path="318" as="126" dim="127" />
-          <Path path="332" as="333" dim="127" />
-          <Path path="334" as="335" dim="127" />
-          <Path path="336" as="337" dim="338" />
+          <Path path="333" as="126" dim="127" />
+          <Path path="360" as="361" dim="127" />
+          <Path path="362" as="363" dim="127" />
+          <Path path="364" as="365" dim="366" />
         </Paths>
       </Formula>
       <Formula id="MucosaVolume_Human.PARAM_VolumeGutWall_Duodenum" name="PARAM_VolumeGutWall_Duodenum" dim="Volume" formula="V_Intestine * 0.087">
         <Paths>
-          <Path path="339" as="340" dim="50" />
-        </Paths>
-      </Formula>
-      <Formula id="Lumen_PKSim.PARAM_Outflow_Duodenum" name="PARAM_Outflow_Duodenum" dim="Inversed time" formula="(k_p*alpha_p*V_p+inflow-k*alpha*V)/(alpha*V)">
-        <Paths>
-          <Path path="239" as="341" dim="24" />
-          <Path path="249" as="342" dim="111" />
-          <Path path="245" as="343" dim="159" />
-          <Path path="134" as="138" dim="50" />
-          <Path path="344" as="345" dim="24" />
-          <Path path="346" as="347" dim="111" />
-          <Path path="348" as="349" dim="50" />
-        </Paths>
-      </Formula>
-      <Formula id="Lumen_Geometry.PARAM_Lumen_Geometry_R2" name="PARAM_Lumen_Geometry_R2" dim="Length" formula="r2_p0 + Height*r2_p1">
-        <Paths>
-          <Path path="318" as="126" dim="127" />
-          <Path path="350" as="351" dim="127" />
-          <Path path="352" as="353" />
-        </Paths>
-      </Formula>
-      <Formula id="Lumen_PKSim.PARAM_EffectiveSurfaceArea" name="PARAM_EffectiveSurfaceArea" dim="Area" formula="Ageom*AeffFactor*AeffVariabilityFactor">
-        <Paths>
-          <Path path="354" as="355" />
-          <Path path="255" as="356" dim="172" />
-          <Path path="357" as="358" />
+          <Path path="367" as="368" dim="55" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_duo" name="PARAM_OralMassAbsorbed_RHS_duo" dim="Amount per time" formula="PassiveRates_para+PassiveRates_trans-(ActiveRates_para+ActiveRates_trans)">
         <Paths>
-          <Path path="359" as="360" dim="361" />
-          <Path path="362" as="363" dim="361" />
-          <Path path="364" as="365" dim="361" />
-          <Path path="366" as="367" dim="361" />
+          <Path path="369" as="370" dim="371" />
+          <Path path="372" as="373" dim="371" />
+          <Path path="374" as="375" dim="371" />
+          <Path path="376" as="377" dim="371" />
         </Paths>
       </Formula>
-      <Formula id="Lumen_PKSim.PARAM_InverseSITT_Factor_UpperJejunum" name="PARAM_InverseSITT_Factor_UpperJejunum" dim="Inversed time" formula="LuminalVelocity/SITT_fact">
+      <Formula id="Lumen_PKSim.PARAM_Outflow_UpperJejunum" name="PARAM_Outflow_UpperJejunum" dim="Inversed time" formula="(k_p*alpha_p*V_p+inflow-k*alpha*V)/(alpha*V)">
         <Paths>
-          <Path path="314" as="315" dim="111" />
-          <Path path="316" as="317" />
+          <Path path="239" as="324" dim="24" />
+          <Path path="249" as="325" dim="50" />
+          <Path path="245" as="326" dim="157" />
+          <Path path="134" as="138" dim="55" />
+          <Path path="378" as="328" dim="24" />
+          <Path path="379" as="330" dim="50" />
+          <Path path="380" as="332" dim="55" />
         </Paths>
       </Formula>
-      <Formula id="MucosaVolume_Human.PARAM_VolumeGutWall_UpperJejunum" name="PARAM_VolumeGutWall_UpperJejunum" dim="Volume" formula="V_Intestine * 0.249">
+      <Formula id="Lumen_PKSim.PARAM_InverseSITT_Factor_UpperJejunum" name="PARAM_InverseSITT_Factor_UpperJejunum" dim="Inversed time" formula="LuminalVelocity/SITT_fact">
         <Paths>
-          <Path path="339" as="340" dim="50" />
+          <Path path="343" as="344" dim="50" />
+          <Path path="345" as="346" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.LiquidRHS_uje" name="LiquidRHS_uje" dim="Flow" formula="OralApplicationsEnabled ? LT_duo - LT_uje + Inflow*FillLevelFlag - Outflow*Liquid : 0">
         <Paths>
-          <Path path="323" as="324" dim="111" />
+          <Path path="351" as="352" dim="50" />
           <Path path="241" as="242" />
-          <Path path="229" as="230" dim="50" />
-          <Path path="243" as="368" dim="159" />
-          <Path path="245" as="246" dim="159" />
-          <Path path="369" as="325" dim="159" />
+          <Path path="229" as="230" dim="55" />
+          <Path path="243" as="381" dim="157" />
+          <Path path="245" as="246" dim="157" />
+          <Path path="382" as="353" dim="157" />
           <Path path="247" as="248" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_LiquidTransferRate_uje" name="PARAM_LiquidTransferRate_uje" dim="Flow" formula="w*Liquid*FillLevelFlagNext">
         <Paths>
-          <Path path="249" as="250" dim="111" />
-          <Path path="229" as="230" dim="50" />
-          <Path path="370" as="252" />
+          <Path path="249" as="250" dim="50" />
+          <Path path="229" as="230" dim="55" />
+          <Path path="383" as="252" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_Inflow_UpperJejunum" name="PARAM_Inflow_UpperJejunum" dim="Flow" formula="0.0031572*V">
         <Paths>
-          <Path path="134" as="138" dim="50" />
+          <Path path="134" as="138" dim="55" />
         </Paths>
       </Formula>
-      <Formula id="Lumen_PKSim.PARAM_Outflow_UpperJejunum" name="PARAM_Outflow_UpperJejunum" dim="Inversed time" formula="(k_p*alpha_p*V_p+inflow-k*alpha*V)/(alpha*V)">
+      <Formula id="MucosaVolume_Human.PARAM_VolumeGutWall_UpperJejunum" name="PARAM_VolumeGutWall_UpperJejunum" dim="Volume" formula="V_Intestine * 0.249">
         <Paths>
-          <Path path="239" as="341" dim="24" />
-          <Path path="249" as="342" dim="111" />
-          <Path path="245" as="343" dim="159" />
-          <Path path="134" as="138" dim="50" />
-          <Path path="371" as="345" dim="24" />
-          <Path path="372" as="347" dim="111" />
-          <Path path="373" as="349" dim="50" />
+          <Path path="367" as="368" dim="55" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_uje" name="PARAM_OralMassAbsorbed_RHS_uje" dim="Amount per time" formula="PassiveRates_para+PassiveRates_trans-(ActiveRates_para+ActiveRates_trans)">
         <Paths>
-          <Path path="374" as="360" dim="361" />
-          <Path path="375" as="363" dim="361" />
-          <Path path="376" as="365" dim="361" />
-          <Path path="377" as="367" dim="361" />
-        </Paths>
-      </Formula>
-      <Formula id="Lumen_PKSim.PARAM_Inflow_LowerJejunum" name="PARAM_Inflow_LowerJejunum" dim="Flow" formula="0.0025102*V">
-        <Paths>
-          <Path path="134" as="138" dim="50" />
+          <Path path="384" as="370" dim="371" />
+          <Path path="385" as="373" dim="371" />
+          <Path path="386" as="375" dim="371" />
+          <Path path="387" as="377" dim="371" />
         </Paths>
       </Formula>
-      <Formula id="MucosaVolume_Human.PARAM_VolumeGutWall_LowerJejunum" name="PARAM_VolumeGutWall_LowerJejunum" dim="Volume" formula="V_Intestine * 0.184">
+      <Formula id="Lumen_PKSim.PARAM_Outflow_LowerJejunum" name="PARAM_Outflow_LowerJejunum" dim="Inversed time" formula="(k_p*alpha_p*V_p+inflow-k*alpha*V)/(alpha*V)">
         <Paths>
-          <Path path="339" as="340" dim="50" />
+          <Path path="239" as="324" dim="24" />
+          <Path path="249" as="325" dim="50" />
+          <Path path="245" as="326" dim="157" />
+          <Path path="134" as="138" dim="55" />
+          <Path path="388" as="328" dim="24" />
+          <Path path="389" as="330" dim="50" />
+          <Path path="390" as="332" dim="55" />
         </Paths>
       </Formula>
-      <Formula id="Lumen_PKSim.PARAM_LiquidTransferRate_lje" name="PARAM_LiquidTransferRate_lje" dim="Flow" formula="w*Liquid*FillLevelFlagNext">
+      <Formula id="Lumen_PKSim.PARAM_InverseSITT_Factor_LowerJejunum" name="PARAM_InverseSITT_Factor_LowerJejunum" dim="Inversed time" formula="LuminalVelocity/SITT_fact">
         <Paths>
-          <Path path="249" as="250" dim="111" />
-          <Path path="229" as="230" dim="50" />
-          <Path path="378" as="252" />
+          <Path path="343" as="344" dim="50" />
+          <Path path="345" as="346" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.LiquidRHS_lje" name="LiquidRHS_lje" dim="Flow" formula="OralApplicationsEnabled ? LT_uje - LT_lje + Inflow*FillLevelFlag - Outflow*Liquid : 0">
         <Paths>
-          <Path path="323" as="324" dim="111" />
+          <Path path="351" as="352" dim="50" />
           <Path path="241" as="242" />
-          <Path path="229" as="230" dim="50" />
-          <Path path="243" as="379" dim="159" />
-          <Path path="245" as="246" dim="159" />
-          <Path path="380" as="368" dim="159" />
+          <Path path="229" as="230" dim="55" />
+          <Path path="243" as="391" dim="157" />
+          <Path path="245" as="246" dim="157" />
+          <Path path="392" as="381" dim="157" />
           <Path path="247" as="248" />
         </Paths>
       </Formula>
-      <Formula id="Lumen_PKSim.PARAM_Outflow_LowerJejunum" name="PARAM_Outflow_LowerJejunum" dim="Inversed time" formula="(k_p*alpha_p*V_p+inflow-k*alpha*V)/(alpha*V)">
+      <Formula id="Lumen_PKSim.PARAM_LiquidTransferRate_lje" name="PARAM_LiquidTransferRate_lje" dim="Flow" formula="w*Liquid*FillLevelFlagNext">
         <Paths>
-          <Path path="239" as="341" dim="24" />
-          <Path path="249" as="342" dim="111" />
-          <Path path="245" as="343" dim="159" />
-          <Path path="134" as="138" dim="50" />
-          <Path path="381" as="345" dim="24" />
-          <Path path="382" as="347" dim="111" />
-          <Path path="383" as="349" dim="50" />
+          <Path path="249" as="250" dim="50" />
+          <Path path="229" as="230" dim="55" />
+          <Path path="393" as="252" />
         </Paths>
       </Formula>
-      <Formula id="Lumen_PKSim.PARAM_InverseSITT_Factor_LowerJejunum" name="PARAM_InverseSITT_Factor_LowerJejunum" dim="Inversed time" formula="LuminalVelocity/SITT_fact">
+      <Formula id="Lumen_PKSim.PARAM_Inflow_LowerJejunum" name="PARAM_Inflow_LowerJejunum" dim="Flow" formula="0.0025102*V">
+        <Paths>
+          <Path path="134" as="138" dim="55" />
+        </Paths>
+      </Formula>
+      <Formula id="MucosaVolume_Human.PARAM_VolumeGutWall_LowerJejunum" name="PARAM_VolumeGutWall_LowerJejunum" dim="Volume" formula="V_Intestine * 0.184">
         <Paths>
-          <Path path="314" as="315" dim="111" />
-          <Path path="316" as="317" />
+          <Path path="367" as="368" dim="55" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_lje" name="PARAM_OralMassAbsorbed_RHS_lje" dim="Amount per time" formula="PassiveRates_para+PassiveRates_trans-(ActiveRates_para+ActiveRates_trans)">
         <Paths>
-          <Path path="384" as="360" dim="361" />
-          <Path path="385" as="363" dim="361" />
-          <Path path="386" as="365" dim="361" />
-          <Path path="387" as="367" dim="361" />
+          <Path path="394" as="370" dim="371" />
+          <Path path="395" as="373" dim="371" />
+          <Path path="396" as="375" dim="371" />
+          <Path path="397" as="377" dim="371" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_Outflow_UpperIleum" name="PARAM_Outflow_UpperIleum" dim="Inversed time" formula="(k_p*alpha_p*V_p+inflow-k*alpha*V)/(alpha*V)">
         <Paths>
-          <Path path="239" as="341" dim="24" />
-          <Path path="249" as="342" dim="111" />
-          <Path path="245" as="343" dim="159" />
-          <Path path="134" as="138" dim="50" />
-          <Path path="388" as="345" dim="24" />
-          <Path path="389" as="347" dim="111" />
-          <Path path="390" as="349" dim="50" />
+          <Path path="239" as="324" dim="24" />
+          <Path path="249" as="325" dim="50" />
+          <Path path="245" as="326" dim="157" />
+          <Path path="134" as="138" dim="55" />
+          <Path path="398" as="328" dim="24" />
+          <Path path="399" as="330" dim="50" />
+          <Path path="400" as="332" dim="55" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_InverseSITT_Factor_UpperIleum" name="PARAM_InverseSITT_Factor_UpperIleum" dim="Inversed time" formula="LuminalVelocity/SITT_fact">
         <Paths>
-          <Path path="314" as="315" dim="111" />
-          <Path path="316" as="317" />
+          <Path path="343" as="344" dim="50" />
+          <Path path="345" as="346" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.LiquidRHS_uil" name="LiquidRHS_uil" dim="Flow" formula="OralApplicationsEnabled ? LT_lje - LT_uil + Inflow*FillLevelFlag - Outflow*Liquid : 0">
         <Paths>
-          <Path path="323" as="324" dim="111" />
+          <Path path="351" as="352" dim="50" />
           <Path path="241" as="242" />
-          <Path path="229" as="230" dim="50" />
-          <Path path="243" as="391" dim="159" />
-          <Path path="245" as="246" dim="159" />
-          <Path path="392" as="379" dim="159" />
+          <Path path="229" as="230" dim="55" />
+          <Path path="243" as="401" dim="157" />
+          <Path path="245" as="246" dim="157" />
+          <Path path="402" as="391" dim="157" />
           <Path path="247" as="248" />
         </Paths>
       </Formula>
-      <Formula id="Lumen_PKSim.PARAM_Inflow_UpperIleum" name="PARAM_Inflow_UpperIleum" dim="Flow" formula="0.0029585*V">
+      <Formula id="Lumen_PKSim.PARAM_LiquidTransferRate_uil" name="PARAM_LiquidTransferRate_uil" dim="Flow" formula="w*Liquid*FillLevelFlagNext">
         <Paths>
-          <Path path="134" as="138" dim="50" />
+          <Path path="249" as="250" dim="50" />
+          <Path path="229" as="230" dim="55" />
+          <Path path="403" as="252" />
         </Paths>
       </Formula>
-      <Formula id="Lumen_PKSim.PARAM_LiquidTransferRate_uil" name="PARAM_LiquidTransferRate_uil" dim="Flow" formula="w*Liquid*FillLevelFlagNext">
+      <Formula id="Lumen_PKSim.PARAM_Inflow_UpperIleum" name="PARAM_Inflow_UpperIleum" dim="Flow" formula="0.0029585*V">
         <Paths>
-          <Path path="249" as="250" dim="111" />
-          <Path path="229" as="230" dim="50" />
-          <Path path="393" as="252" />
+          <Path path="134" as="138" dim="55" />
         </Paths>
       </Formula>
       <Formula id="MucosaVolume_Human.PARAM_VolumeGutWall_UpperIleum" name="PARAM_VolumeGutWall_UpperIleum" dim="Volume" formula="V_Intestine * 0.324">
         <Paths>
-          <Path path="339" as="340" dim="50" />
+          <Path path="367" as="368" dim="55" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_uil" name="PARAM_OralMassAbsorbed_RHS_uil" dim="Amount per time" formula="PassiveRates_para+PassiveRates_trans-(ActiveRates_para+ActiveRates_trans)">
         <Paths>
-          <Path path="394" as="360" dim="361" />
-          <Path path="395" as="363" dim="361" />
-          <Path path="396" as="365" dim="361" />
-          <Path path="397" as="367" dim="361" />
-        </Paths>
-      </Formula>
-      <Formula id="MucosaVolume_Human.PARAM_VolumeGutWall_LowerIleum" name="PARAM_VolumeGutWall_LowerIleum" dim="Volume" formula="V_Intestine * 0.156">
-        <Paths>
-          <Path path="339" as="340" dim="50" />
+          <Path path="404" as="370" dim="371" />
+          <Path path="405" as="373" dim="371" />
+          <Path path="406" as="375" dim="371" />
+          <Path path="407" as="377" dim="371" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_Outflow_LowerIleum" name="PARAM_Outflow_LowerIleum" dim="Inversed time" formula="(k_p*alpha_p*V_p+inflow-k*alpha*V)/(alpha*V)">
         <Paths>
-          <Path path="239" as="341" dim="24" />
-          <Path path="249" as="342" dim="111" />
-          <Path path="245" as="343" dim="159" />
-          <Path path="134" as="138" dim="50" />
-          <Path path="398" as="345" dim="24" />
-          <Path path="399" as="347" dim="111" />
-          <Path path="400" as="349" dim="50" />
+          <Path path="239" as="324" dim="24" />
+          <Path path="249" as="325" dim="50" />
+          <Path path="245" as="326" dim="157" />
+          <Path path="134" as="138" dim="55" />
+          <Path path="408" as="328" dim="24" />
+          <Path path="409" as="330" dim="50" />
+          <Path path="410" as="332" dim="55" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_InverseSITT_Factor_LowerIleum" name="PARAM_InverseSITT_Factor_LowerIleum" dim="Inversed time" formula="LuminalVelocity/SITT_fact">
         <Paths>
-          <Path path="314" as="315" dim="111" />
-          <Path path="316" as="317" />
+          <Path path="343" as="344" dim="50" />
+          <Path path="345" as="346" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.LiquidRHS_lil" name="LiquidRHS_lil" dim="Flow" formula="OralApplicationsEnabled ? LT_uil - LT_lil + Inflow*FillLevelFlag - Outflow*Liquid : 0">
         <Paths>
-          <Path path="323" as="324" dim="111" />
+          <Path path="351" as="352" dim="50" />
           <Path path="241" as="242" />
-          <Path path="229" as="230" dim="50" />
-          <Path path="243" as="401" dim="159" />
-          <Path path="245" as="246" dim="159" />
-          <Path path="402" as="391" dim="159" />
+          <Path path="229" as="230" dim="55" />
+          <Path path="243" as="411" dim="157" />
+          <Path path="245" as="246" dim="157" />
+          <Path path="412" as="401" dim="157" />
           <Path path="247" as="248" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_LiquidTransferRate_lil" name="PARAM_LiquidTransferRate_lil" dim="Flow" formula="w*Liquid*FillLevelFlagNext">
         <Paths>
-          <Path path="249" as="250" dim="111" />
-          <Path path="229" as="230" dim="50" />
-          <Path path="403" as="252" />
+          <Path path="249" as="250" dim="50" />
+          <Path path="229" as="230" dim="55" />
+          <Path path="413" as="252" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_Inflow_LowerIleum" name="PARAM_Inflow_LowerIleum" dim="Flow" formula="0.0017657*V">
         <Paths>
-          <Path path="134" as="138" dim="50" />
+          <Path path="134" as="138" dim="55" />
         </Paths>
       </Formula>
-      <Formula id="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_lil" name="PARAM_OralMassAbsorbed_RHS_lil" dim="Amount per time" formula="PassiveRates_para+PassiveRates_trans-(ActiveRates_para+ActiveRates_trans)">
+      <Formula id="MucosaVolume_Human.PARAM_VolumeGutWall_LowerIleum" name="PARAM_VolumeGutWall_LowerIleum" dim="Volume" formula="V_Intestine * 0.156">
         <Paths>
-          <Path path="404" as="360" dim="361" />
-          <Path path="405" as="363" dim="361" />
-          <Path path="406" as="365" dim="361" />
-          <Path path="407" as="367" dim="361" />
+          <Path path="367" as="368" dim="55" />
         </Paths>
       </Formula>
-      <Formula id="MucosaVolume_Human.PARAM_VolumeGutWall_Caecum" name="PARAM_VolumeGutWall_Caecum" dim="Volume" formula="V_Intestine * 0.08470588">
+      <Formula id="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_lil" name="PARAM_OralMassAbsorbed_RHS_lil" dim="Amount per time" formula="PassiveRates_para+PassiveRates_trans-(ActiveRates_para+ActiveRates_trans)">
         <Paths>
-          <Path path="408" as="340" dim="50" />
+          <Path path="414" as="370" dim="371" />
+          <Path path="415" as="373" dim="371" />
+          <Path path="416" as="375" dim="371" />
+          <Path path="417" as="377" dim="371" />
         </Paths>
       </Formula>
-      <Formula id="Lumen_PKSim.PARAM_InverseLITT_Factor_Caecum" name="PARAM_InverseLITT_Factor_Caecum" dim="Inversed time" formula="LuminalVelocity/LITT_fact">
+      <Formula id="Lumen_PKSim.PARAM_Outflow_Caecum" name="PARAM_Outflow_Caecum" dim="Inversed time" formula="(k_p*alpha_p*V_p+inflow-k*alpha*V)/(alpha*V)">
         <Paths>
-          <Path path="314" as="315" dim="111" />
-          <Path path="409" as="410" />
+          <Path path="239" as="324" dim="24" />
+          <Path path="249" as="325" dim="50" />
+          <Path path="245" as="326" dim="157" />
+          <Path path="134" as="138" dim="55" />
+          <Path path="418" as="328" dim="24" />
+          <Path path="419" as="330" dim="50" />
+          <Path path="420" as="332" dim="55" />
         </Paths>
       </Formula>
-      <Formula id="Lumen_PKSim.PARAM_Outflow_Caecum" name="PARAM_Outflow_Caecum" dim="Inversed time" formula="(k_p*alpha_p*V_p+inflow-k*alpha*V)/(alpha*V)">
+      <Formula id="Lumen_PKSim.PARAM_InverseLITT_Factor_Caecum" name="PARAM_InverseLITT_Factor_Caecum" dim="Inversed time" formula="LuminalVelocity/LITT_fact">
         <Paths>
-          <Path path="239" as="341" dim="24" />
-          <Path path="249" as="342" dim="111" />
-          <Path path="245" as="343" dim="159" />
-          <Path path="134" as="138" dim="50" />
-          <Path path="411" as="345" dim="24" />
-          <Path path="412" as="347" dim="111" />
-          <Path path="413" as="349" dim="50" />
+          <Path path="343" as="344" dim="50" />
+          <Path path="421" as="422" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.LiquidRHS_cae" name="LiquidRHS_cae" dim="Flow" formula="OralApplicationsEnabled ? LT_lil - LT_cae + Inflow*FillLevelFlag - Outflow*Liquid : 0">
         <Paths>
-          <Path path="323" as="324" dim="111" />
+          <Path path="351" as="352" dim="50" />
           <Path path="241" as="242" />
-          <Path path="229" as="230" dim="50" />
-          <Path path="243" as="414" dim="159" />
-          <Path path="245" as="246" dim="159" />
-          <Path path="415" as="401" dim="159" />
+          <Path path="229" as="230" dim="55" />
+          <Path path="243" as="423" dim="157" />
+          <Path path="245" as="246" dim="157" />
+          <Path path="424" as="411" dim="157" />
           <Path path="247" as="248" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_LiquidTransferRate_cae" name="PARAM_LiquidTransferRate_cae" dim="Flow" formula="w*Liquid*FillLevelFlagNext">
         <Paths>
-          <Path path="249" as="250" dim="111" />
-          <Path path="229" as="230" dim="50" />
-          <Path path="416" as="252" />
+          <Path path="249" as="250" dim="50" />
+          <Path path="229" as="230" dim="55" />
+          <Path path="425" as="252" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_Inflow_Caecum" name="PARAM_Inflow_Caecum" dim="Flow" formula="0*V">
         <Paths>
-          <Path path="134" as="138" dim="50" />
+          <Path path="134" as="138" dim="55" />
+        </Paths>
+      </Formula>
+      <Formula id="MucosaVolume_Human.PARAM_VolumeGutWall_Caecum" name="PARAM_VolumeGutWall_Caecum" dim="Volume" formula="V_Intestine * 0.08470588">
+        <Paths>
+          <Path path="426" as="368" dim="55" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_cae" name="PARAM_OralMassAbsorbed_RHS_cae" dim="Amount per time" formula="PassiveRates_para+PassiveRates_trans-(ActiveRates_para+ActiveRates_trans)">
         <Paths>
-          <Path path="417" as="360" dim="361" />
-          <Path path="418" as="363" dim="361" />
-          <Path path="419" as="365" dim="361" />
-          <Path path="420" as="367" dim="361" />
+          <Path path="427" as="370" dim="371" />
+          <Path path="428" as="373" dim="371" />
+          <Path path="429" as="375" dim="371" />
+          <Path path="430" as="377" dim="371" />
         </Paths>
       </Formula>
-      <Formula id="MucosaVolume_Human.PARAM_VolumeGutWall_ColonAscendens" name="PARAM_VolumeGutWall_ColonAscendens" dim="Volume" formula="V_Intestine * 0.15529412">
+      <Formula id="Lumen_PKSim.PARAM_Outflow_ColonAscendens" name="PARAM_Outflow_ColonAscendens" dim="Inversed time" formula="(k_p*alpha_p*V_p+inflow-k*alpha*V)/(alpha*V)">
         <Paths>
-          <Path path="408" as="340" dim="50" />
+          <Path path="239" as="324" dim="24" />
+          <Path path="249" as="325" dim="50" />
+          <Path path="245" as="326" dim="157" />
+          <Path path="134" as="138" dim="55" />
+          <Path path="431" as="328" dim="24" />
+          <Path path="432" as="330" dim="50" />
+          <Path path="433" as="332" dim="55" />
         </Paths>
       </Formula>
-      <Formula id="Lumen_PKSim.LiquidRHS_colasc" name="LiquidRHS_colasc" dim="Flow" formula="OralApplicationsEnabled ? LT_cae - LT_colasc + Inflow*FillLevelFlag - Outflow*Liquid : 0">
+      <Formula id="Lumen_PKSim.PARAM_InverseLITT_Factor_ColonAscendens" name="PARAM_InverseLITT_Factor_ColonAscendens" dim="Inversed time" formula="LuminalVelocity/LITT_fact">
         <Paths>
-          <Path path="323" as="324" dim="111" />
-          <Path path="241" as="242" />
-          <Path path="229" as="230" dim="50" />
-          <Path path="243" as="421" dim="159" />
-          <Path path="245" as="246" dim="159" />
-          <Path path="422" as="414" dim="159" />
-          <Path path="247" as="248" />
+          <Path path="343" as="344" dim="50" />
+          <Path path="421" as="422" />
         </Paths>
       </Formula>
-      <Formula id="Lumen_PKSim.PARAM_Outflow_ColonAscendens" name="PARAM_Outflow_ColonAscendens" dim="Inversed time" formula="(k_p*alpha_p*V_p+inflow-k*alpha*V)/(alpha*V)">
+      <Formula id="Lumen_PKSim.LiquidRHS_colasc" name="LiquidRHS_colasc" dim="Flow" formula="OralApplicationsEnabled ? LT_cae - LT_colasc + Inflow*FillLevelFlag - Outflow*Liquid : 0">
         <Paths>
-          <Path path="239" as="341" dim="24" />
-          <Path path="249" as="342" dim="111" />
-          <Path path="245" as="343" dim="159" />
-          <Path path="134" as="138" dim="50" />
-          <Path path="423" as="345" dim="24" />
-          <Path path="424" as="347" dim="111" />
-          <Path path="425" as="349" dim="50" />
+          <Path path="351" as="352" dim="50" />
+          <Path path="241" as="242" />
+          <Path path="229" as="230" dim="55" />
+          <Path path="243" as="434" dim="157" />
+          <Path path="245" as="246" dim="157" />
+          <Path path="435" as="423" dim="157" />
+          <Path path="247" as="248" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_LiquidTransferRate_colasc" name="PARAM_LiquidTransferRate_colasc" dim="Flow" formula="w*Liquid*FillLevelFlagNext">
         <Paths>
-          <Path path="249" as="250" dim="111" />
-          <Path path="229" as="230" dim="50" />
-          <Path path="426" as="252" />
+          <Path path="249" as="250" dim="50" />
+          <Path path="229" as="230" dim="55" />
+          <Path path="436" as="252" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_Inflow_ColonAscendens" name="PARAM_Inflow_ColonAscendens" dim="Flow" formula="0.00098426*V">
         <Paths>
-          <Path path="134" as="138" dim="50" />
+          <Path path="134" as="138" dim="55" />
         </Paths>
       </Formula>
-      <Formula id="Lumen_PKSim.PARAM_InverseLITT_Factor_ColonAscendens" name="PARAM_InverseLITT_Factor_ColonAscendens" dim="Inversed time" formula="LuminalVelocity/LITT_fact">
+      <Formula id="MucosaVolume_Human.PARAM_VolumeGutWall_ColonAscendens" name="PARAM_VolumeGutWall_ColonAscendens" dim="Volume" formula="V_Intestine * 0.15529412">
         <Paths>
-          <Path path="314" as="315" dim="111" />
-          <Path path="409" as="410" />
+          <Path path="426" as="368" dim="55" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_colasc" name="PARAM_OralMassAbsorbed_RHS_colasc" dim="Amount per time" formula="PassiveRates_para+PassiveRates_trans-(ActiveRates_para+ActiveRates_trans)">
         <Paths>
-          <Path path="427" as="360" dim="361" />
-          <Path path="428" as="363" dim="361" />
-          <Path path="429" as="365" dim="361" />
-          <Path path="430" as="367" dim="361" />
+          <Path path="437" as="370" dim="371" />
+          <Path path="438" as="373" dim="371" />
+          <Path path="439" as="375" dim="371" />
+          <Path path="440" as="377" dim="371" />
         </Paths>
       </Formula>
-      <Formula id="Lumen_PKSim.PARAM_InverseLITT_Factor_ColonTransversum" name="PARAM_InverseLITT_Factor_ColonTransversum" dim="Inversed time" formula="LuminalVelocity/LITT_fact">
+      <Formula id="Lumen_PKSim.PARAM_Outflow_ColonTransversum" name="PARAM_Outflow_ColonTransversum" dim="Inversed time" formula="(k_p*alpha_p*V_p+inflow-k*alpha*V)/(alpha*V)">
         <Paths>
-          <Path path="314" as="315" dim="111" />
-          <Path path="409" as="410" />
+          <Path path="239" as="324" dim="24" />
+          <Path path="249" as="325" dim="50" />
+          <Path path="245" as="326" dim="157" />
+          <Path path="134" as="138" dim="55" />
+          <Path path="441" as="328" dim="24" />
+          <Path path="442" as="330" dim="50" />
+          <Path path="443" as="332" dim="55" />
         </Paths>
       </Formula>
-      <Formula id="Lumen_PKSim.PARAM_LiquidTransferRate_coltrans" name="PARAM_LiquidTransferRate_coltrans" dim="Flow" formula="w*Liquid*FillLevelFlagNext">
+      <Formula id="Lumen_PKSim.PARAM_InverseLITT_Factor_ColonTransversum" name="PARAM_InverseLITT_Factor_ColonTransversum" dim="Inversed time" formula="LuminalVelocity/LITT_fact">
         <Paths>
-          <Path path="249" as="250" dim="111" />
-          <Path path="229" as="230" dim="50" />
-          <Path path="431" as="252" />
+          <Path path="343" as="344" dim="50" />
+          <Path path="421" as="422" />
         </Paths>
       </Formula>
-      <Formula id="Lumen_PKSim.PARAM_Inflow_ColonTransversum" name="PARAM_Inflow_ColonTransversum" dim="Flow" formula="0.00020285*V">
+      <Formula id="Lumen_PKSim.LiquidRHS_coltrans" name="LiquidRHS_coltrans" dim="Flow" formula="OralApplicationsEnabled ? LT_colasc - LT_coltrans + Inflow*FillLevelFlag - Outflow*Liquid : 0">
         <Paths>
-          <Path path="134" as="138" dim="50" />
+          <Path path="351" as="352" dim="50" />
+          <Path path="241" as="242" />
+          <Path path="229" as="230" dim="55" />
+          <Path path="243" as="444" dim="157" />
+          <Path path="245" as="246" dim="157" />
+          <Path path="445" as="434" dim="157" />
+          <Path path="247" as="248" />
         </Paths>
       </Formula>
-      <Formula id="MucosaVolume_Human.PARAM_VolumeGutWall_ColonTransversum" name="PARAM_VolumeGutWall_ColonTransversum" dim="Volume" formula="V_Intestine * 0.32">
+      <Formula id="Lumen_PKSim.PARAM_LiquidTransferRate_coltrans" name="PARAM_LiquidTransferRate_coltrans" dim="Flow" formula="w*Liquid*FillLevelFlagNext">
         <Paths>
-          <Path path="408" as="340" dim="50" />
+          <Path path="249" as="250" dim="50" />
+          <Path path="229" as="230" dim="55" />
+          <Path path="446" as="252" />
         </Paths>
       </Formula>
-      <Formula id="Lumen_PKSim.LiquidRHS_coltrans" name="LiquidRHS_coltrans" dim="Flow" formula="OralApplicationsEnabled ? LT_colasc - LT_coltrans + Inflow*FillLevelFlag - Outflow*Liquid : 0">
+      <Formula id="Lumen_PKSim.PARAM_Inflow_ColonTransversum" name="PARAM_Inflow_ColonTransversum" dim="Flow" formula="0.00020285*V">
         <Paths>
-          <Path path="323" as="324" dim="111" />
-          <Path path="241" as="242" />
-          <Path path="229" as="230" dim="50" />
-          <Path path="243" as="432" dim="159" />
-          <Path path="245" as="246" dim="159" />
-          <Path path="433" as="421" dim="159" />
-          <Path path="247" as="248" />
+          <Path path="134" as="138" dim="55" />
         </Paths>
       </Formula>
-      <Formula id="Lumen_PKSim.PARAM_Outflow_ColonTransversum" name="PARAM_Outflow_ColonTransversum" dim="Inversed time" formula="(k_p*alpha_p*V_p+inflow-k*alpha*V)/(alpha*V)">
+      <Formula id="MucosaVolume_Human.PARAM_VolumeGutWall_ColonTransversum" name="PARAM_VolumeGutWall_ColonTransversum" dim="Volume" formula="V_Intestine * 0.32">
         <Paths>
-          <Path path="239" as="341" dim="24" />
-          <Path path="249" as="342" dim="111" />
-          <Path path="245" as="343" dim="159" />
-          <Path path="134" as="138" dim="50" />
-          <Path path="434" as="345" dim="24" />
-          <Path path="435" as="347" dim="111" />
-          <Path path="436" as="349" dim="50" />
+          <Path path="426" as="368" dim="55" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_coltrans" name="PARAM_OralMassAbsorbed_RHS_coltrans" dim="Amount per time" formula="PassiveRates_para+PassiveRates_trans-(ActiveRates_para+ActiveRates_trans)">
         <Paths>
-          <Path path="437" as="360" dim="361" />
-          <Path path="438" as="363" dim="361" />
-          <Path path="439" as="365" dim="361" />
-          <Path path="440" as="367" dim="361" />
+          <Path path="447" as="370" dim="371" />
+          <Path path="448" as="373" dim="371" />
+          <Path path="449" as="375" dim="371" />
+          <Path path="450" as="377" dim="371" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_Outflow_ColonDescendens" name="PARAM_Outflow_ColonDescendens" dim="Inversed time" formula="(k_p*alpha_p*V_p+inflow-k*alpha*V)/(alpha*V)">
         <Paths>
-          <Path path="239" as="341" dim="24" />
-          <Path path="249" as="342" dim="111" />
-          <Path path="245" as="343" dim="159" />
-          <Path path="134" as="138" dim="50" />
-          <Path path="441" as="345" dim="24" />
-          <Path path="442" as="347" dim="111" />
-          <Path path="443" as="349" dim="50" />
+          <Path path="239" as="324" dim="24" />
+          <Path path="249" as="325" dim="50" />
+          <Path path="245" as="326" dim="157" />
+          <Path path="134" as="138" dim="55" />
+          <Path path="451" as="328" dim="24" />
+          <Path path="452" as="330" dim="50" />
+          <Path path="453" as="332" dim="55" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_InverseLITT_Factor_ColonDescendens" name="PARAM_InverseLITT_Factor_ColonDescendens" dim="Inversed time" formula="LuminalVelocity/LITT_fact">
         <Paths>
-          <Path path="314" as="315" dim="111" />
-          <Path path="409" as="410" />
+          <Path path="343" as="344" dim="50" />
+          <Path path="421" as="422" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.LiquidRHS_coldesc" name="LiquidRHS_coldesc" dim="Flow" formula="OralApplicationsEnabled ? LT_coltrans - LT_coldesc + Inflow*FillLevelFlag - Outflow*Liquid : 0">
         <Paths>
-          <Path path="323" as="324" dim="111" />
+          <Path path="351" as="352" dim="50" />
           <Path path="241" as="242" />
-          <Path path="229" as="230" dim="50" />
-          <Path path="243" as="444" dim="159" />
-          <Path path="245" as="246" dim="159" />
-          <Path path="445" as="432" dim="159" />
+          <Path path="229" as="230" dim="55" />
+          <Path path="243" as="454" dim="157" />
+          <Path path="245" as="246" dim="157" />
+          <Path path="455" as="444" dim="157" />
           <Path path="247" as="248" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_LiquidTransferRate_coldesc" name="PARAM_LiquidTransferRate_coldesc" dim="Flow" formula="w*Liquid*FillLevelFlagNext">
         <Paths>
-          <Path path="249" as="250" dim="111" />
-          <Path path="229" as="230" dim="50" />
-          <Path path="446" as="252" />
+          <Path path="249" as="250" dim="50" />
+          <Path path="229" as="230" dim="55" />
+          <Path path="456" as="252" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_Inflow_ColonDescendens" name="PARAM_Inflow_ColonDescendens" dim="Flow" formula="0.00023004*V">
         <Paths>
-          <Path path="134" as="138" dim="50" />
+          <Path path="134" as="138" dim="55" />
         </Paths>
       </Formula>
       <Formula id="MucosaVolume_Human.PARAM_VolumeGutWall_ColonDescendens" name="PARAM_VolumeGutWall_ColonDescendens" dim="Volume" formula="V_Intestine * 0.24">
         <Paths>
-          <Path path="408" as="340" dim="50" />
+          <Path path="426" as="368" dim="55" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_coldesc" name="PARAM_OralMassAbsorbed_RHS_coldesc" dim="Amount per time" formula="PassiveRates_para+PassiveRates_trans-(ActiveRates_para+ActiveRates_trans)">
         <Paths>
-          <Path path="447" as="360" dim="361" />
-          <Path path="448" as="363" dim="361" />
-          <Path path="449" as="365" dim="361" />
-          <Path path="450" as="367" dim="361" />
+          <Path path="457" as="370" dim="371" />
+          <Path path="458" as="373" dim="371" />
+          <Path path="459" as="375" dim="371" />
+          <Path path="460" as="377" dim="371" />
+        </Paths>
+      </Formula>
+      <Formula id="Lumen_PKSim.PARAM_Outflow_ColonSigmoid" name="PARAM_Outflow_ColonSigmoid" dim="Inversed time" formula="(k_p*alpha_p*V_p+inflow-k*alpha*V)/(alpha*V)">
+        <Paths>
+          <Path path="239" as="324" dim="24" />
+          <Path path="249" as="325" dim="50" />
+          <Path path="245" as="326" dim="157" />
+          <Path path="134" as="138" dim="55" />
+          <Path path="461" as="328" dim="24" />
+          <Path path="462" as="330" dim="50" />
+          <Path path="463" as="332" dim="55" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_InverseLITT_Factor_ColonSigmoid" name="PARAM_InverseLITT_Factor_ColonSigmoid" dim="Inversed time" formula="LuminalVelocity/LITT_fact">
         <Paths>
-          <Path path="314" as="315" dim="111" />
-          <Path path="409" as="410" />
+          <Path path="343" as="344" dim="50" />
+          <Path path="421" as="422" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.LiquidRHS_colsigm" name="LiquidRHS_colsigm" dim="Flow" formula="OralApplicationsEnabled ? LT_coldesc - LT_colsigm + Inflow*FillLevelFlag - Outflow*Liquid : 0">
         <Paths>
-          <Path path="323" as="324" dim="111" />
+          <Path path="351" as="352" dim="50" />
           <Path path="241" as="242" />
-          <Path path="229" as="230" dim="50" />
-          <Path path="243" as="451" dim="159" />
-          <Path path="245" as="246" dim="159" />
-          <Path path="452" as="444" dim="159" />
+          <Path path="229" as="230" dim="55" />
+          <Path path="243" as="464" dim="157" />
+          <Path path="245" as="246" dim="157" />
+          <Path path="465" as="454" dim="157" />
           <Path path="247" as="248" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_LiquidTransferRate_colsigm" name="PARAM_LiquidTransferRate_colsigm" dim="Flow" formula="w*Liquid*FillLevelFlagNext">
         <Paths>
-          <Path path="249" as="250" dim="111" />
-          <Path path="229" as="230" dim="50" />
-          <Path path="453" as="252" />
+          <Path path="249" as="250" dim="50" />
+          <Path path="229" as="230" dim="55" />
+          <Path path="466" as="252" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_Inflow_ColonSigmoid" name="PARAM_Inflow_ColonSigmoid" dim="Flow" formula="0.00013099*V">
         <Paths>
-          <Path path="134" as="138" dim="50" />
+          <Path path="134" as="138" dim="55" />
         </Paths>
       </Formula>
       <Formula id="MucosaVolume_Human.PARAM_VolumeGutWall_ColonSigmoid" name="PARAM_VolumeGutWall_ColonSigmoid" dim="Volume" formula="V_Intestine * 0.135">
         <Paths>
-          <Path path="408" as="340" dim="50" />
-        </Paths>
-      </Formula>
-      <Formula id="Lumen_PKSim.PARAM_Outflow_ColonSigmoid" name="PARAM_Outflow_ColonSigmoid" dim="Inversed time" formula="(k_p*alpha_p*V_p+inflow-k*alpha*V)/(alpha*V)">
-        <Paths>
-          <Path path="239" as="341" dim="24" />
-          <Path path="249" as="342" dim="111" />
-          <Path path="245" as="343" dim="159" />
-          <Path path="134" as="138" dim="50" />
-          <Path path="454" as="345" dim="24" />
-          <Path path="455" as="347" dim="111" />
-          <Path path="456" as="349" dim="50" />
+          <Path path="426" as="368" dim="55" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_colsigm" name="PARAM_OralMassAbsorbed_RHS_colsigm" dim="Amount per time" formula="PassiveRates_para+PassiveRates_trans-(ActiveRates_para+ActiveRates_trans)">
         <Paths>
-          <Path path="457" as="360" dim="361" />
-          <Path path="458" as="363" dim="361" />
-          <Path path="459" as="365" dim="361" />
-          <Path path="460" as="367" dim="361" />
+          <Path path="467" as="370" dim="371" />
+          <Path path="468" as="373" dim="371" />
+          <Path path="469" as="375" dim="371" />
+          <Path path="470" as="377" dim="371" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_Outflow_Rectum" name="PARAM_Outflow_Rectum" dim="Inversed time" formula="(k_p*alpha_p*V_p+inflow-k*alpha*V)/(alpha*V)">
         <Paths>
-          <Path path="239" as="341" dim="24" />
-          <Path path="249" as="342" dim="111" />
-          <Path path="245" as="343" dim="159" />
-          <Path path="134" as="138" dim="50" />
-          <Path path="461" as="345" dim="24" />
-          <Path path="462" as="347" dim="111" />
-          <Path path="463" as="349" dim="50" />
+          <Path path="239" as="324" dim="24" />
+          <Path path="249" as="325" dim="50" />
+          <Path path="245" as="326" dim="157" />
+          <Path path="134" as="138" dim="55" />
+          <Path path="471" as="328" dim="24" />
+          <Path path="472" as="330" dim="50" />
+          <Path path="473" as="332" dim="55" />
         </Paths>
       </Formula>
-      <Formula id="MucosaVolume_Human.PARAM_VolumeGutWall_Rectum" name="PARAM_VolumeGutWall_Rectum" dim="Volume" formula="V_Intestine * 0.055">
+      <Formula id="Lumen_PKSim.PARAM_InverseLITT_Factor_Rectum" name="PARAM_InverseLITT_Factor_Rectum" dim="Inversed time" formula="LuminalVelocity/LITT_fact">
         <Paths>
-          <Path path="408" as="340" dim="50" />
+          <Path path="343" as="344" dim="50" />
+          <Path path="421" as="422" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.LiquidRHS_rect" name="LiquidRHS_rect" dim="Flow" formula="OralApplicationsEnabled ? LT_colsigm - LT_rect + Inflow*FillLevelFlag : 0">
         <Paths>
           <Path path="241" as="242" />
-          <Path path="243" as="464" dim="159" />
-          <Path path="245" as="246" dim="159" />
-          <Path path="465" as="451" dim="159" />
+          <Path path="243" as="474" dim="157" />
+          <Path path="245" as="246" dim="157" />
+          <Path path="475" as="464" dim="157" />
           <Path path="247" as="248" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_LiquidTransferRate_rect" name="PARAM_LiquidTransferRate_rect" dim="Flow" formula="w*Liquid">
         <Paths>
-          <Path path="249" as="250" dim="111" />
-          <Path path="229" as="230" dim="50" />
+          <Path path="249" as="250" dim="50" />
+          <Path path="229" as="230" dim="55" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_Inflow_Rectum" name="PARAM_Inflow_Rectum" dim="Flow" formula="0.00071247*V">
         <Paths>
-          <Path path="134" as="138" dim="50" />
+          <Path path="134" as="138" dim="55" />
         </Paths>
       </Formula>
-      <Formula id="Lumen_PKSim.PARAM_InverseLITT_Factor_Rectum" name="PARAM_InverseLITT_Factor_Rectum" dim="Inversed time" formula="LuminalVelocity/LITT_fact">
+      <Formula id="MucosaVolume_Human.PARAM_VolumeGutWall_Rectum" name="PARAM_VolumeGutWall_Rectum" dim="Volume" formula="V_Intestine * 0.055">
         <Paths>
-          <Path path="314" as="315" dim="111" />
-          <Path path="409" as="410" />
+          <Path path="426" as="368" dim="55" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_rect" name="PARAM_OralMassAbsorbed_RHS_rect" dim="Amount per time" formula="PassiveRates_para+PassiveRates_trans-(ActiveRates_para+ActiveRates_trans)">
         <Paths>
-          <Path path="466" as="360" dim="361" />
-          <Path path="467" as="363" dim="361" />
-          <Path path="468" as="365" dim="361" />
-          <Path path="469" as="367" dim="361" />
+          <Path path="476" as="370" dim="371" />
+          <Path path="477" as="373" dim="371" />
+          <Path path="478" as="375" dim="371" />
+          <Path path="479" as="377" dim="371" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.LiquidRHS_fec" name="LiquidRHS_fec" dim="Flow" formula="OralApplicationsEnabled ? LT_rec : 0">
         <Paths>
-          <Path path="470" as="471" dim="159" />
+          <Path path="480" as="481" dim="157" />
           <Path path="247" as="248" />
         </Paths>
       </Formula>
       <Formula id="VascularEndoVolume.VOLUME_VascularEndo_sto" name="VOLUME_VascularEndo_sto" dim="Volume" formula="SA_pls_int*d_endo">
         <Paths>
-          <Path path="168" as="169" dim="127" />
-          <Path path="472" as="171" dim="172" />
+          <Path path="166" as="167" dim="127" />
+          <Path path="482" as="169" dim="170" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_sto" name="PARAM_K_Water_INT_sto" formula="K_water_int">
         <Paths>
-          <Path path="473" as="181" />
+          <Path path="483" as="179" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_sto" name="PARAM_K_Water_CELL_sto" formula="K_water_cell">
         <Paths>
-          <Path path="474" as="185" />
+          <Path path="484" as="183" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_SITT_Factor" name="PARAM_SITT_Factor" formula="P1*SITT+P2">
         <Paths>
-          <Path path="475" as="476" dim="143" />
-          <Path path="477" as="478" />
-          <Path path="479" as="480" dim="111" />
+          <Path path="485" as="486" dim="143" />
+          <Path path="487" as="488" />
+          <Path path="489" as="490" dim="50" />
         </Paths>
       </Formula>
       <Formula id="Individual_PKSim.PARAM_FluidRecirculationRate_sin" name="PARAM_FluidRecirculationRate_sin" dim="Flow" formula="J_iso_incl_Mucosa-J_iso_duo-J_iso_uje-J_iso_lje-J_iso_uil-J_iso_lil">
         <Paths>
-          <Path path="481" as="482" dim="159" />
-          <Path path="483" as="484" dim="159" />
-          <Path path="485" as="486" dim="159" />
-          <Path path="487" as="488" dim="159" />
-          <Path path="489" as="490" dim="159" />
-          <Path path="491" as="492" dim="159" />
+          <Path path="491" as="492" dim="157" />
+          <Path path="493" as="494" dim="157" />
+          <Path path="495" as="496" dim="157" />
+          <Path path="497" as="498" dim="157" />
+          <Path path="499" as="500" dim="157" />
+          <Path path="501" as="502" dim="157" />
         </Paths>
       </Formula>
-      <Formula id="VascularEndoVolume.VOLUME_VascularEndo_sin" name="VOLUME_VascularEndo_sin" dim="Volume" formula="SA_pls_int*d_endo">
+      <Formula id="Individual_PKSim.PARAM_Q_Lymph_sin" name="PARAM_Q_Lymph_sin" dim="Flow" formula="Q_lymph_incl_Mucosa-Q_lymph_duo-Q_lymph_uje-Q_lymph_lje-Q_lymph_uil-Q_lymph_lil">
         <Paths>
-          <Path path="168" as="169" dim="127" />
-          <Path path="493" as="171" dim="172" />
+          <Path path="503" as="504" dim="157" />
+          <Path path="505" as="506" dim="157" />
+          <Path path="507" as="508" dim="157" />
+          <Path path="509" as="510" dim="157" />
+          <Path path="511" as="512" dim="157" />
+          <Path path="513" as="514" dim="157" />
         </Paths>
       </Formula>
-      <Formula id="Individual_PKSim.PARAM_Q_Lymph_sin" name="PARAM_Q_Lymph_sin" dim="Flow" formula="Q_lymph_incl_Mucosa-Q_lymph_duo-Q_lymph_uje-Q_lymph_lje-Q_lymph_uil-Q_lymph_lil">
+      <Formula id="VascularEndoVolume.VOLUME_VascularEndo_sin" name="VOLUME_VascularEndo_sin" dim="Volume" formula="SA_pls_int*d_endo">
         <Paths>
-          <Path path="494" as="495" dim="159" />
-          <Path path="496" as="497" dim="159" />
-          <Path path="498" as="499" dim="159" />
-          <Path path="500" as="501" dim="159" />
-          <Path path="502" as="503" dim="159" />
-          <Path path="504" as="505" dim="159" />
+          <Path path="166" as="167" dim="127" />
+          <Path path="515" as="169" dim="170" />
         </Paths>
       </Formula>
       <Formula id="MucosaVolume.VOLUME_SmallIntestineMucosa" name="VOLUME_SmallIntestineMucosa" dim="Volume" formula="V_duo+V_uje+V_lje+V_uil+V_lil">
         <Paths>
-          <Path path="506" as="507" dim="50" />
-          <Path path="508" as="509" dim="50" />
-          <Path path="510" as="511" dim="50" />
-          <Path path="512" as="513" dim="50" />
-          <Path path="514" as="515" dim="50" />
+          <Path path="516" as="517" dim="55" />
+          <Path path="518" as="519" dim="55" />
+          <Path path="520" as="521" dim="55" />
+          <Path path="522" as="523" dim="55" />
+          <Path path="524" as="525" dim="55" />
         </Paths>
       </Formula>
       <Formula id="CompartmentsVolume_4Comp.VOLUME_pls_SinLin" name="VOLUME_pls_SinLin" dim="Volume" formula="f_vas*(1-HCT)*(V-V_Mucosa)">
         <Paths>
           <Path path="135" as="136" />
-          <Path path="137" as="138" dim="50" />
-          <Path path="516" as="517" dim="50" />
+          <Path path="137" as="138" dim="55" />
+          <Path path="526" as="527" dim="55" />
           <Path path="40" as="41" />
         </Paths>
       </Formula>
       <Formula id="CompartmentsVolume_4Comp.VOLUME_bc_SinLin" name="VOLUME_bc_SinLin" dim="Volume" formula="f_vas*HCT*(V-V_Mucosa)">
         <Paths>
           <Path path="135" as="136" />
-          <Path path="137" as="138" dim="50" />
-          <Path path="516" as="517" dim="50" />
+          <Path path="137" as="138" dim="55" />
+          <Path path="526" as="527" dim="55" />
           <Path path="40" as="41" />
         </Paths>
       </Formula>
       <Formula id="CompartmentsVolume_4Comp.VOLUME_int_SinLin" name="VOLUME_int_SinLin" dim="Volume" formula="f_int*(V-V_Mucosa)">
         <Paths>
-          <Path path="177" as="174" />
-          <Path path="137" as="138" dim="50" />
-          <Path path="516" as="517" dim="50" />
+          <Path path="175" as="172" />
+          <Path path="137" as="138" dim="55" />
+          <Path path="526" as="527" dim="55" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_sin" name="PARAM_K_Water_INT_sin" formula="K_water_int">
         <Paths>
-          <Path path="518" as="181" />
+          <Path path="528" as="179" />
         </Paths>
       </Formula>
       <Formula id="CompoundCommon.PARAM_ProteinContainerVolume_Organ_SinLin" name="PARAM_ProteinContainerVolume_Organ_SinLin" dim="Volume" formula="Volume-V_Mucosa">
         <Paths>
-          <Path path="137" as="50" dim="50" />
-          <Path path="516" as="517" dim="50" />
+          <Path path="137" as="55" dim="55" />
+          <Path path="526" as="527" dim="55" />
         </Paths>
       </Formula>
       <Formula id="CompartmentsVolume_4Comp.VOLUME_cell_SinLin" name="VOLUME_cell_SinLin" dim="Volume" formula="f_cell*(V-V_Mucosa)">
         <Paths>
-          <Path path="182" as="183" />
-          <Path path="137" as="138" dim="50" />
-          <Path path="516" as="517" dim="50" />
+          <Path path="180" as="181" />
+          <Path path="137" as="138" dim="55" />
+          <Path path="526" as="527" dim="55" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_sin" name="PARAM_K_Water_CELL_sin" formula="K_water_cell">
         <Paths>
-          <Path path="519" as="185" />
+          <Path path="529" as="183" />
         </Paths>
       </Formula>
       <Formula id="MucosaVolume.VOLUME_MucosaDuodenum" name="VOLUME_MucosaDuodenum" dim="Volume" formula="V_GutWall*fractionMucosa">
         <Paths>
-          <Path path="520" as="521" />
-          <Path path="522" as="523" dim="50" />
+          <Path path="530" as="531" />
+          <Path path="532" as="533" dim="55" />
         </Paths>
       </Formula>
-      <Formula id="Individual_PKSim.PARAM_Q_lymph_mucosa" name="PARAM_Q_lymph_mucosa" dim="Flow" formula="Q_lymph_intestine * V_seg / V_intestine">
+      <Formula id="Individual_PKSim.PARAM_J_iso_Mucosa" name="PARAM_J_iso_Mucosa" dim="Flow" formula="J_iso_intestine * V_seg / V_intestine">
         <Paths>
-          <Path path="524" as="525" dim="159" />
-          <Path path="526" as="527" dim="50" />
-          <Path path="134" as="528" dim="50" />
+          <Path path="534" as="535" dim="157" />
+          <Path path="536" as="537" dim="55" />
+          <Path path="134" as="538" dim="55" />
         </Paths>
       </Formula>
-      <Formula id="VascularEndoVolume.VOLUME_VascularEndo_duo" name="VOLUME_VascularEndo_duo" dim="Volume" formula="SA_pls_int*d_endo">
+      <Formula id="Individual_PKSim.PARAM_Q_lymph_mucosa" name="PARAM_Q_lymph_mucosa" dim="Flow" formula="Q_lymph_intestine * V_seg / V_intestine">
         <Paths>
-          <Path path="168" as="169" dim="127" />
-          <Path path="529" as="171" dim="172" />
+          <Path path="539" as="540" dim="157" />
+          <Path path="536" as="537" dim="55" />
+          <Path path="134" as="538" dim="55" />
         </Paths>
       </Formula>
-      <Formula id="Individual_PKSim.PARAM_J_iso_Mucosa" name="PARAM_J_iso_Mucosa" dim="Flow" formula="J_iso_intestine * V_seg / V_intestine">
+      <Formula id="VascularEndoVolume.VOLUME_VascularEndo_duo" name="VOLUME_VascularEndo_duo" dim="Volume" formula="SA_pls_int*d_endo">
         <Paths>
-          <Path path="530" as="531" dim="159" />
-          <Path path="526" as="527" dim="50" />
-          <Path path="134" as="528" dim="50" />
+          <Path path="166" as="167" dim="127" />
+          <Path path="541" as="169" dim="170" />
         </Paths>
       </Formula>
       <Formula id="Individual_PKSim.PARAM_Q_mucosa" name="PARAM_Q_mucosa" dim="Flow" formula="Q * fractQ * regionalFractQ">
         <Paths>
-          <Path path="532" as="165" dim="159" />
-          <Path path="533" as="534" />
-          <Path path="535" as="536" />
+          <Path path="542" as="163" dim="157" />
+          <Path path="543" as="544" />
+          <Path path="545" as="546" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_duo" name="PARAM_K_Water_INT_duo" formula="K_water_int">
         <Paths>
-          <Path path="537" as="181" />
+          <Path path="547" as="179" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_duo" name="PARAM_K_Water_CELL_duo" formula="K_water_cell">
         <Paths>
-          <Path path="538" as="185" />
+          <Path path="548" as="183" />
         </Paths>
       </Formula>
       <Formula id="MucosaVolume.VOLUME_MucosaUpperJejunum" name="VOLUME_MucosaUpperJejunum" dim="Volume" formula="V_GutWall*fractionMucosa">
         <Paths>
-          <Path path="520" as="521" />
-          <Path path="539" as="523" dim="50" />
+          <Path path="530" as="531" />
+          <Path path="549" as="533" dim="55" />
         </Paths>
       </Formula>
       <Formula id="VascularEndoVolume.VOLUME_VascularEndo_uje" name="VOLUME_VascularEndo_uje" dim="Volume" formula="SA_pls_int*d_endo">
         <Paths>
-          <Path path="168" as="169" dim="127" />
-          <Path path="540" as="171" dim="172" />
+          <Path path="166" as="167" dim="127" />
+          <Path path="550" as="169" dim="170" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_uje" name="PARAM_K_Water_INT_uje" formula="K_water_int">
         <Paths>
-          <Path path="541" as="181" />
+          <Path path="551" as="179" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_uje" name="PARAM_K_Water_CELL_uje" formula="K_water_cell">
         <Paths>
-          <Path path="542" as="185" />
+          <Path path="552" as="183" />
         </Paths>
       </Formula>
       <Formula id="MucosaVolume.VOLUME_MucosaLowerJejunum" name="VOLUME_MucosaLowerJejunum" dim="Volume" formula="V_GutWall*fractionMucosa">
         <Paths>
-          <Path path="520" as="521" />
-          <Path path="543" as="523" dim="50" />
+          <Path path="530" as="531" />
+          <Path path="553" as="533" dim="55" />
         </Paths>
       </Formula>
       <Formula id="VascularEndoVolume.VOLUME_VascularEndo_lje" name="VOLUME_VascularEndo_lje" dim="Volume" formula="SA_pls_int*d_endo">
         <Paths>
-          <Path path="168" as="169" dim="127" />
-          <Path path="544" as="171" dim="172" />
+          <Path path="166" as="167" dim="127" />
+          <Path path="554" as="169" dim="170" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_lje" name="PARAM_K_Water_INT_lje" formula="K_water_int">
         <Paths>
-          <Path path="545" as="181" />
+          <Path path="555" as="179" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_lje" name="PARAM_K_Water_CELL_lje" formula="K_water_cell">
         <Paths>
-          <Path path="546" as="185" />
+          <Path path="556" as="183" />
         </Paths>
       </Formula>
       <Formula id="MucosaVolume.VOLUME_MucosaUpperIleum" name="VOLUME_MucosaUpperIleum" dim="Volume" formula="V_GutWall*fractionMucosa">
         <Paths>
-          <Path path="520" as="521" />
-          <Path path="547" as="523" dim="50" />
+          <Path path="530" as="531" />
+          <Path path="557" as="533" dim="55" />
         </Paths>
       </Formula>
       <Formula id="VascularEndoVolume.VOLUME_VascularEndo_uil" name="VOLUME_VascularEndo_uil" dim="Volume" formula="SA_pls_int*d_endo">
         <Paths>
-          <Path path="168" as="169" dim="127" />
-          <Path path="548" as="171" dim="172" />
+          <Path path="166" as="167" dim="127" />
+          <Path path="558" as="169" dim="170" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_uil" name="PARAM_K_Water_INT_uil" formula="K_water_int">
         <Paths>
-          <Path path="549" as="181" />
+          <Path path="559" as="179" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_uil" name="PARAM_K_Water_CELL_uil" formula="K_water_cell">
         <Paths>
-          <Path path="550" as="185" />
+          <Path path="560" as="183" />
         </Paths>
       </Formula>
       <Formula id="MucosaVolume.VOLUME_MucosaLowerIleum" name="VOLUME_MucosaLowerIleum" dim="Volume" formula="V_GutWall*fractionMucosa">
         <Paths>
-          <Path path="520" as="521" />
-          <Path path="551" as="523" dim="50" />
+          <Path path="530" as="531" />
+          <Path path="561" as="533" dim="55" />
         </Paths>
       </Formula>
       <Formula id="VascularEndoVolume.VOLUME_VascularEndo_lil" name="VOLUME_VascularEndo_lil" dim="Volume" formula="SA_pls_int*d_endo">
         <Paths>
-          <Path path="168" as="169" dim="127" />
-          <Path path="552" as="171" dim="172" />
+          <Path path="166" as="167" dim="127" />
+          <Path path="562" as="169" dim="170" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_lil" name="PARAM_K_Water_INT_lil" formula="K_water_int">
         <Paths>
-          <Path path="553" as="181" />
+          <Path path="563" as="179" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_lil" name="PARAM_K_Water_CELL_lil" formula="K_water_cell">
         <Paths>
-          <Path path="554" as="185" />
+          <Path path="564" as="183" />
         </Paths>
       </Formula>
-      <Formula id="MucosaVolume.VOLUME_LargeIntestineMucosa" name="VOLUME_LargeIntestineMucosa" dim="Volume" formula="V_cae+V_ca+V_ct+V_cd+V_cs+V_rec">
+      <Formula id="Lumen_PKSim.PARAM_LITT_Factor" name="PARAM_LITT_Factor" formula="P1*LITT+P2">
         <Paths>
-          <Path path="555" as="556" dim="50" />
-          <Path path="557" as="558" dim="50" />
-          <Path path="559" as="560" dim="50" />
-          <Path path="561" as="562" dim="50" />
-          <Path path="563" as="564" dim="50" />
-          <Path path="565" as="566" dim="50" />
+          <Path path="565" as="566" dim="143" />
+          <Path path="567" as="488" />
+          <Path path="568" as="490" dim="50" />
         </Paths>
       </Formula>
-      <Formula id="Lumen_PKSim.PARAM_LITT_Factor" name="PARAM_LITT_Factor" formula="P1*LITT+P2">
+      <Formula id="MucosaVolume.VOLUME_LargeIntestineMucosa" name="VOLUME_LargeIntestineMucosa" dim="Volume" formula="V_cae+V_ca+V_ct+V_cd+V_cs+V_rec">
         <Paths>
-          <Path path="567" as="568" dim="143" />
-          <Path path="569" as="478" />
-          <Path path="570" as="480" dim="111" />
+          <Path path="569" as="570" dim="55" />
+          <Path path="571" as="572" dim="55" />
+          <Path path="573" as="574" dim="55" />
+          <Path path="575" as="576" dim="55" />
+          <Path path="577" as="578" dim="55" />
+          <Path path="579" as="580" dim="55" />
         </Paths>
       </Formula>
-      <Formula id="VascularEndoVolume.VOLUME_VascularEndo_lin" name="VOLUME_VascularEndo_lin" dim="Volume" formula="SA_pls_int*d_endo">
+      <Formula id="Individual_PKSim.PARAM_FluidRecirculationRate_lin" name="PARAM_FluidRecirculationRate_lin" dim="Flow" formula="J_iso_incl_Mucosa-J_iso_cae-J_iso_colasc-J_iso_coltrans-J_iso_coldesc-J_iso_colsigm-J_iso_rect">
         <Paths>
-          <Path path="168" as="169" dim="127" />
-          <Path path="571" as="171" dim="172" />
+          <Path path="491" as="492" dim="157" />
+          <Path path="581" as="582" dim="157" />
+          <Path path="583" as="584" dim="157" />
+          <Path path="585" as="586" dim="157" />
+          <Path path="587" as="588" dim="157" />
+          <Path path="589" as="590" dim="157" />
+          <Path path="591" as="592" dim="157" />
         </Paths>
       </Formula>
       <Formula id="Individual_PKSim.PARAM_Q_Lymph_lin" name="PARAM_Q_Lymph_lin" dim="Flow" formula="Q_lymph_incl_Mucosa-Q_lymph_cae-Q_lymph_colasc-Q_lymph_coltrans-Q_lymph_coldesc-Q_lymph_colsigm-Q_lymph_rect">
         <Paths>
-          <Path path="494" as="495" dim="159" />
-          <Path path="572" as="573" dim="159" />
-          <Path path="574" as="575" dim="159" />
-          <Path path="576" as="577" dim="159" />
-          <Path path="578" as="579" dim="159" />
-          <Path path="580" as="581" dim="159" />
-          <Path path="582" as="583" dim="159" />
+          <Path path="503" as="504" dim="157" />
+          <Path path="593" as="594" dim="157" />
+          <Path path="595" as="596" dim="157" />
+          <Path path="597" as="598" dim="157" />
+          <Path path="599" as="600" dim="157" />
+          <Path path="601" as="602" dim="157" />
+          <Path path="603" as="604" dim="157" />
         </Paths>
       </Formula>
-      <Formula id="Individual_PKSim.PARAM_FluidRecirculationRate_lin" name="PARAM_FluidRecirculationRate_lin" dim="Flow" formula="J_iso_incl_Mucosa-J_iso_cae-J_iso_colasc-J_iso_coltrans-J_iso_coldesc-J_iso_colsigm-J_iso_rect">
+      <Formula id="VascularEndoVolume.VOLUME_VascularEndo_lin" name="VOLUME_VascularEndo_lin" dim="Volume" formula="SA_pls_int*d_endo">
         <Paths>
-          <Path path="481" as="482" dim="159" />
-          <Path path="584" as="585" dim="159" />
-          <Path path="586" as="587" dim="159" />
-          <Path path="588" as="589" dim="159" />
-          <Path path="590" as="591" dim="159" />
-          <Path path="592" as="593" dim="159" />
-          <Path path="594" as="595" dim="159" />
+          <Path path="166" as="167" dim="127" />
+          <Path path="605" as="169" dim="170" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_lin" name="PARAM_K_Water_INT_lin" formula="K_water_int">
         <Paths>
-          <Path path="596" as="181" />
+          <Path path="606" as="179" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_lin" name="PARAM_K_Water_CELL_lin" formula="K_water_cell">
         <Paths>
-          <Path path="597" as="185" />
+          <Path path="607" as="183" />
         </Paths>
       </Formula>
       <Formula id="MucosaVolume.VOLUME_MucosaCaecum" name="VOLUME_MucosaCaecum" dim="Volume" formula="V_GutWall*fractionMucosa">
         <Paths>
-          <Path path="520" as="521" />
-          <Path path="598" as="523" dim="50" />
+          <Path path="530" as="531" />
+          <Path path="608" as="533" dim="55" />
         </Paths>
       </Formula>
       <Formula id="VascularEndoVolume.VOLUME_VascularEndo_cae" name="VOLUME_VascularEndo_cae" dim="Volume" formula="SA_pls_int*d_endo">
         <Paths>
-          <Path path="168" as="169" dim="127" />
-          <Path path="599" as="171" dim="172" />
+          <Path path="166" as="167" dim="127" />
+          <Path path="609" as="169" dim="170" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_cae" name="PARAM_K_Water_INT_cae" formula="K_water_int">
         <Paths>
-          <Path path="600" as="181" />
+          <Path path="610" as="179" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_cae" name="PARAM_K_Water_CELL_cae" formula="K_water_cell">
         <Paths>
-          <Path path="601" as="185" />
+          <Path path="611" as="183" />
         </Paths>
       </Formula>
       <Formula id="MucosaVolume.VOLUME_MucosaColonAscendens" name="VOLUME_MucosaColonAscendens" dim="Volume" formula="V_GutWall*fractionMucosa">
         <Paths>
-          <Path path="520" as="521" />
-          <Path path="602" as="523" dim="50" />
+          <Path path="530" as="531" />
+          <Path path="612" as="533" dim="55" />
         </Paths>
       </Formula>
       <Formula id="VascularEndoVolume.VOLUME_VascularEndo_colasc" name="VOLUME_VascularEndo_colasc" dim="Volume" formula="SA_pls_int*d_endo">
         <Paths>
-          <Path path="168" as="169" dim="127" />
-          <Path path="603" as="171" dim="172" />
+          <Path path="166" as="167" dim="127" />
+          <Path path="613" as="169" dim="170" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_colasc" name="PARAM_K_Water_INT_colasc" formula="K_water_int">
         <Paths>
-          <Path path="604" as="181" />
+          <Path path="614" as="179" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_colasc" name="PARAM_K_Water_CELL_colasc" formula="K_water_cell">
         <Paths>
-          <Path path="605" as="185" />
+          <Path path="615" as="183" />
         </Paths>
       </Formula>
       <Formula id="MucosaVolume.VOLUME_MucosaColonTransversum" name="VOLUME_MucosaColonTransversum" dim="Volume" formula="V_GutWall*fractionMucosa">
         <Paths>
-          <Path path="520" as="521" />
-          <Path path="606" as="523" dim="50" />
+          <Path path="530" as="531" />
+          <Path path="616" as="533" dim="55" />
         </Paths>
       </Formula>
       <Formula id="VascularEndoVolume.VOLUME_VascularEndo_coltrans" name="VOLUME_VascularEndo_coltrans" dim="Volume" formula="SA_pls_int*d_endo">
         <Paths>
-          <Path path="168" as="169" dim="127" />
-          <Path path="607" as="171" dim="172" />
+          <Path path="166" as="167" dim="127" />
+          <Path path="617" as="169" dim="170" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_coltrans" name="PARAM_K_Water_INT_coltrans" formula="K_water_int">
         <Paths>
-          <Path path="608" as="181" />
+          <Path path="618" as="179" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_coltrans" name="PARAM_K_Water_CELL_coltrans" formula="K_water_cell">
         <Paths>
-          <Path path="609" as="185" />
+          <Path path="619" as="183" />
         </Paths>
       </Formula>
       <Formula id="MucosaVolume.VOLUME_MucosaColonDescendens" name="VOLUME_MucosaColonDescendens" dim="Volume" formula="V_GutWall*fractionMucosa">
         <Paths>
-          <Path path="520" as="521" />
-          <Path path="610" as="523" dim="50" />
+          <Path path="530" as="531" />
+          <Path path="620" as="533" dim="55" />
         </Paths>
       </Formula>
       <Formula id="VascularEndoVolume.VOLUME_VascularEndo_coldesc" name="VOLUME_VascularEndo_coldesc" dim="Volume" formula="SA_pls_int*d_endo">
         <Paths>
-          <Path path="168" as="169" dim="127" />
-          <Path path="611" as="171" dim="172" />
+          <Path path="166" as="167" dim="127" />
+          <Path path="621" as="169" dim="170" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_coldesc" name="PARAM_K_Water_INT_coldesc" formula="K_water_int">
         <Paths>
-          <Path path="612" as="181" />
+          <Path path="622" as="179" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_coldesc" name="PARAM_K_Water_CELL_coldesc" formula="K_water_cell">
         <Paths>
-          <Path path="613" as="185" />
+          <Path path="623" as="183" />
         </Paths>
       </Formula>
       <Formula id="MucosaVolume.VOLUME_MucosaColonSigmoid" name="VOLUME_MucosaColonSigmoid" dim="Volume" formula="V_GutWall*fractionMucosa">
         <Paths>
-          <Path path="520" as="521" />
-          <Path path="614" as="523" dim="50" />
+          <Path path="530" as="531" />
+          <Path path="624" as="533" dim="55" />
         </Paths>
       </Formula>
       <Formula id="VascularEndoVolume.VOLUME_VascularEndo_colsigm" name="VOLUME_VascularEndo_colsigm" dim="Volume" formula="SA_pls_int*d_endo">
         <Paths>
-          <Path path="168" as="169" dim="127" />
-          <Path path="615" as="171" dim="172" />
+          <Path path="166" as="167" dim="127" />
+          <Path path="625" as="169" dim="170" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_colsigm" name="PARAM_K_Water_INT_colsigm" formula="K_water_int">
         <Paths>
-          <Path path="616" as="181" />
+          <Path path="626" as="179" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_colsigm" name="PARAM_K_Water_CELL_colsigm" formula="K_water_cell">
         <Paths>
-          <Path path="617" as="185" />
+          <Path path="627" as="183" />
         </Paths>
       </Formula>
       <Formula id="MucosaVolume.VOLUME_MucosaRectum" name="VOLUME_MucosaRectum" dim="Volume" formula="V_GutWall*fractionMucosa">
         <Paths>
-          <Path path="520" as="521" />
-          <Path path="618" as="523" dim="50" />
+          <Path path="530" as="531" />
+          <Path path="628" as="533" dim="55" />
         </Paths>
       </Formula>
       <Formula id="VascularEndoVolume.VOLUME_VascularEndo_rect" name="VOLUME_VascularEndo_rect" dim="Volume" formula="SA_pls_int*d_endo">
         <Paths>
-          <Path path="168" as="169" dim="127" />
-          <Path path="619" as="171" dim="172" />
+          <Path path="166" as="167" dim="127" />
+          <Path path="629" as="169" dim="170" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_rect" name="PARAM_K_Water_INT_rect" formula="K_water_int">
         <Paths>
-          <Path path="620" as="181" />
+          <Path path="630" as="179" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_rect" name="PARAM_K_Water_CELL_rect" formula="K_water_cell">
         <Paths>
-          <Path path="621" as="185" />
+          <Path path="631" as="183" />
         </Paths>
       </Formula>
       <Formula id="VascularEndoVolume.VOLUME_VascularEndo_liv" name="VOLUME_VascularEndo_liv" dim="Volume" formula="SA_pls_int*d_endo">
         <Paths>
-          <Path path="168" as="169" dim="127" />
-          <Path path="622" as="171" dim="172" />
+          <Path path="166" as="167" dim="127" />
+          <Path path="632" as="169" dim="170" />
         </Paths>
       </Formula>
-      <Formula id="Individual_PKSim.PARAM_Fraction of blood for sampling_LiverZone" name="PARAM_Fraction of blood for sampling_LiverZone" formula="Liver_Parameter">
+      <Formula id="Individual_PKSim.PARAM_Allometric scale factor_LiverZone" name="PARAM_Allometric scale factor_LiverZone" formula="Liver_Parameter">
         <Paths>
-          <Path path="623" as="624" />
+          <Path path="633" as="634" />
         </Paths>
       </Formula>
       <Formula id="Individual_PKSim.PARAM_Density (tissue)_LiverZone" name="PARAM_Density (tissue)_LiverZone" dim="Density" formula="Liver_Parameter">
         <Paths>
-          <Path path="625" as="624" dim="133" />
+          <Path path="635" as="634" dim="133" />
         </Paths>
       </Formula>
-      <Formula id="Individual_PKSim.PARAM_Allometric scale factor_LiverZone" name="PARAM_Allometric scale factor_LiverZone" formula="Liver_Parameter">
+      <Formula id="Individual_PKSim.PARAM_Fraction of blood for sampling_LiverZone" name="PARAM_Fraction of blood for sampling_LiverZone" formula="Liver_Parameter">
         <Paths>
-          <Path path="626" as="624" />
+          <Path path="636" as="634" />
         </Paths>
       </Formula>
       <Formula id="Individual_PKSim.PARAM_Volume_Periportal" name="PARAM_Volume_Periportal" dim="Volume" formula="V_liv * (IsLiverZonated ? f_periportal : 1)">
         <Paths>
-          <Path path="627" as="628" dim="24" />
-          <Path path="629" as="630" />
-          <Path path="631" as="632" dim="50" />
+          <Path path="637" as="638" dim="24" />
+          <Path path="639" as="640" />
+          <Path path="641" as="642" dim="55" />
         </Paths>
       </Formula>
-      <Formula id="Individual_PKSim.PARAM_Radius (small pores)_LiverZone" name="PARAM_Radius (small pores)_LiverZone" dim="Length" formula="Liver_Parameter">
+      <Formula id="Individual_PKSim.PARAM_Flow fraction via large pores_LiverZone" name="PARAM_Flow fraction via large pores_LiverZone" formula="Liver_Parameter">
         <Paths>
-          <Path path="633" as="624" dim="127" />
+          <Path path="643" as="634" />
         </Paths>
       </Formula>
-      <Formula id="Individual_PKSim.PARAM_Radius (large pores)_LiverZone" name="PARAM_Radius (large pores)_LiverZone" dim="Length" formula="Liver_Parameter">
+      <Formula id="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate_Liver_Periportal" name="PARAM_Fluid_recirculation_flow_rate_Liver_Periportal" dim="Flow" formula="J_iso * (IsLiverZonated?  f_periportal : 1)">
         <Paths>
-          <Path path="634" as="624" dim="127" />
+          <Path path="644" as="645" dim="157" />
+          <Path path="637" as="638" dim="24" />
+          <Path path="639" as="640" />
         </Paths>
       </Formula>
-      <Formula id="VascularEndoVolume.VOLUME_VascularEndo_liv_periportal" name="VOLUME_VascularEndo_liv_periportal" dim="Volume" formula="SA_pls_int*d_endo">
+      <Formula id="Individual_PKSim.PARAM_Hydraulic conductivity_LiverZone" name="PARAM_Hydraulic conductivity_LiverZone" dim="Hydraulic conductivity" formula="Liver_Parameter">
         <Paths>
-          <Path path="168" as="169" dim="127" />
-          <Path path="635" as="171" dim="172" />
+          <Path path="646" as="634" dim="647" />
         </Paths>
       </Formula>
       <Formula id="Individual_PKSim.PARAM_Lymph_flow_rate_Liver_Periportal" name="PARAM_Lymph_flow_rate_Liver_Periportal" dim="Flow" formula="Q_lymph * (IsLiverZonated?  f_periportal : 1)">
         <Paths>
-          <Path path="636" as="158" dim="159" />
-          <Path path="627" as="628" dim="24" />
-          <Path path="629" as="630" />
+          <Path path="648" as="156" dim="157" />
+          <Path path="637" as="638" dim="24" />
+          <Path path="639" as="640" />
         </Paths>
       </Formula>
-      <Formula id="Individual_PKSim.PARAM_Hydraulic conductivity_LiverZone" name="PARAM_Hydraulic conductivity_LiverZone" dim="Hydraulic conductivity" formula="Liver_Parameter">
+      <Formula id="Individual_PKSim.PARAM_Radius (large pores)_LiverZone" name="PARAM_Radius (large pores)_LiverZone" dim="Length" formula="Liver_Parameter">
         <Paths>
-          <Path path="637" as="624" dim="638" />
+          <Path path="649" as="634" dim="127" />
         </Paths>
       </Formula>
-      <Formula id="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate_Liver_Periportal" name="PARAM_Fluid_recirculation_flow_rate_Liver_Periportal" dim="Flow" formula="J_iso * (IsLiverZonated?  f_periportal : 1)">
+      <Formula id="Individual_PKSim.PARAM_Radius (small pores)_LiverZone" name="PARAM_Radius (small pores)_LiverZone" dim="Length" formula="Liver_Parameter">
         <Paths>
-          <Path path="639" as="640" dim="159" />
-          <Path path="627" as="628" dim="24" />
-          <Path path="629" as="630" />
+          <Path path="650" as="634" dim="127" />
         </Paths>
       </Formula>
-      <Formula id="Individual_PKSim.PARAM_Flow fraction via large pores_LiverZone" name="PARAM_Flow fraction via large pores_LiverZone" formula="Liver_Parameter">
+      <Formula id="VascularEndoVolume.VOLUME_VascularEndo_liv_periportal" name="VOLUME_VascularEndo_liv_periportal" dim="Volume" formula="SA_pls_int*d_endo">
         <Paths>
-          <Path path="641" as="624" />
+          <Path path="166" as="167" dim="127" />
+          <Path path="651" as="169" dim="170" />
         </Paths>
       </Formula>
-      <Formula id="Individual_PKSim.PARAM_Vf (neutral lipid)-PT_LiverZone" name="PARAM_Vf (neutral lipid)-PT_LiverZone" formula="Liver_Parameter">
+      <Formula id="Individual_PKSim.PARAM_Vf (lipid)_LiverZone" name="PARAM_Vf (lipid)_LiverZone" formula="Liver_Parameter">
         <Paths>
-          <Path path="642" as="624" />
+          <Path path="652" as="634" />
         </Paths>
       </Formula>
-      <Formula id="Individual_PKSim.PARAM_Vf (lipid)_LiverZone" name="PARAM_Vf (lipid)_LiverZone" formula="Liver_Parameter">
+      <Formula id="Individual_PKSim.PARAM_Vf (neutral lipid)-PT_LiverZone" name="PARAM_Vf (neutral lipid)-PT_LiverZone" formula="Liver_Parameter">
         <Paths>
-          <Path path="643" as="624" />
+          <Path path="653" as="634" />
         </Paths>
       </Formula>
       <Formula id="Individual_PKSim.PARAM_Vf (phospholipid)-PT_LiverZone" name="PARAM_Vf (phospholipid)-PT_LiverZone" formula="Liver_Parameter">
         <Paths>
-          <Path path="644" as="624" />
+          <Path path="654" as="634" />
         </Paths>
       </Formula>
       <Formula id="Individual_PKSim.PARAM_Vf (protein)_LiverZone" name="PARAM_Vf (protein)_LiverZone" formula="Liver_Parameter">
         <Paths>
-          <Path path="645" as="624" />
+          <Path path="655" as="634" />
         </Paths>
       </Formula>
       <Formula id="Individual_PKSim.PARAM_Albumin ratio (tissue/plasma)_LiverZone" name="PARAM_Albumin ratio (tissue/plasma)_LiverZone" formula="Liver_Parameter">
         <Paths>
-          <Path path="646" as="624" />
+          <Path path="656" as="634" />
         </Paths>
       </Formula>
-      <Formula id="Individual_PKSim.PARAM_Lipoprotein ratio (tissue/plasma)_LiverZone" name="PARAM_Lipoprotein ratio (tissue/plasma)_LiverZone" formula="Liver_Parameter">
+      <Formula id="Individual_PKSim.PARAM_Albumin ratio (tissue/plasma)-PT_LiverZone" name="PARAM_Albumin ratio (tissue/plasma)-PT_LiverZone" formula="Liver_Parameter">
         <Paths>
-          <Path path="647" as="624" />
+          <Path path="657" as="634" />
         </Paths>
       </Formula>
-      <Formula id="Individual_PKSim.PARAM_Vf (water)-PT_LiverZone" name="PARAM_Vf (water)-PT_LiverZone" formula="Liver_Parameter">
+      <Formula id="Individual_PKSim.PARAM_Fraction vascular_LiverZone" name="PARAM_Fraction vascular_LiverZone" formula="Liver_Parameter">
         <Paths>
-          <Path path="648" as="624" />
+          <Path path="135" as="634" />
         </Paths>
       </Formula>
-      <Formula id="Individual_PKSim.PARAM_Number of cells/g tissue_LiverZone" name="PARAM_Number of cells/g tissue_LiverZone" dim="Count per mass" formula="Liver_Parameter">
+      <Formula id="Individual_PKSim.PARAM_Lipoprotein ratio (tissue/plasma)_LiverZone" name="PARAM_Lipoprotein ratio (tissue/plasma)_LiverZone" formula="Liver_Parameter">
         <Paths>
-          <Path path="649" as="624" dim="650" />
+          <Path path="658" as="634" />
         </Paths>
       </Formula>
       <Formula id="Individual_PKSim.PARAM_Microsomal protein mass/g tissue_LiverZone" name="PARAM_Microsomal protein mass/g tissue_LiverZone" dim="Mass per tissue" formula="Liver_Parameter">
         <Paths>
-          <Path path="651" as="624" dim="652" />
+          <Path path="659" as="634" dim="660" />
         </Paths>
       </Formula>
-      <Formula id="Individual_PKSim.PARAM_Albumin ratio (tissue/plasma)-PT_LiverZone" name="PARAM_Albumin ratio (tissue/plasma)-PT_LiverZone" formula="Liver_Parameter">
+      <Formula id="Individual_PKSim.PARAM_Number of cells/g tissue_LiverZone" name="PARAM_Number of cells/g tissue_LiverZone" dim="Count per mass" formula="Liver_Parameter">
         <Paths>
-          <Path path="653" as="624" />
+          <Path path="661" as="634" dim="662" />
         </Paths>
       </Formula>
-      <Formula id="Individual_PKSim.PARAM_Fraction vascular_LiverZone" name="PARAM_Fraction vascular_LiverZone" formula="Liver_Parameter">
+      <Formula id="Individual_PKSim.PARAM_Vf (water)_LiverZone" name="PARAM_Vf (water)_LiverZone" formula="Liver_Parameter">
         <Paths>
-          <Path path="135" as="624" />
+          <Path path="663" as="634" />
         </Paths>
       </Formula>
-      <Formula id="Individual_PKSim.PARAM_Vf (water)_LiverZone" name="PARAM_Vf (water)_LiverZone" formula="Liver_Parameter">
+      <Formula id="Individual_PKSim.PARAM_Vf (water)-PT_LiverZone" name="PARAM_Vf (water)-PT_LiverZone" formula="Liver_Parameter">
         <Paths>
-          <Path path="654" as="624" />
+          <Path path="664" as="634" />
         </Paths>
       </Formula>
       <Formula id="Individual_PKSim.PARAM_f_cell_LiverZone" name="PARAM_f_cell_LiverZone" formula="Liver_Parameter">
         <Paths>
-          <Path path="182" as="624" />
+          <Path path="180" as="634" />
         </Paths>
       </Formula>
       <Formula id="Individual_PKSim.PARAM_Fraction interstitial_LiverZone" name="PARAM_Fraction interstitial_LiverZone" formula="Liver_Parameter">
         <Paths>
-          <Path path="177" as="624" />
+          <Path path="175" as="634" />
         </Paths>
       </Formula>
       <Formula id="Individual_PKSim.PARAM_Vf (neutral lipid)-RR_LiverZone" name="PARAM_Vf (neutral lipid)-RR_LiverZone" formula="Liver_Parameter">
         <Paths>
-          <Path path="655" as="624" />
+          <Path path="665" as="634" />
         </Paths>
       </Formula>
       <Formula id="Individual_PKSim.PARAM_Vf (neutral lipid)-WS_LiverZone" name="PARAM_Vf (neutral lipid)-WS_LiverZone" formula="Liver_Parameter">
         <Paths>
-          <Path path="656" as="624" />
+          <Path path="666" as="634" />
         </Paths>
       </Formula>
       <Formula id="Individual_PKSim.PARAM_Vf (neutral phospholipid)-RR_LiverZone" name="PARAM_Vf (neutral phospholipid)-RR_LiverZone" formula="Liver_Parameter">
         <Paths>
-          <Path path="657" as="624" />
+          <Path path="667" as="634" />
         </Paths>
       </Formula>
       <Formula id="Individual_PKSim.PARAM_Vf (neutral phospholipid, plasma)-WS_LiverZone" name="PARAM_Vf (neutral phospholipid, plasma)-WS_LiverZone" formula="Liver_Parameter">
         <Paths>
-          <Path path="658" as="624" />
+          <Path path="668" as="634" />
         </Paths>
       </Formula>
-      <Formula id="Individual_PKSim.PARAM_Vf (protein)-WS_LiverZone" name="PARAM_Vf (protein)-WS_LiverZone" formula="Liver_Parameter">
+      <Formula id="Individual_PKSim.PARAM_Vf (extracellular water)-RR_LiverZone" name="PARAM_Vf (extracellular water)-RR_LiverZone" formula="Liver_Parameter">
         <Paths>
-          <Path path="659" as="624" />
+          <Path path="669" as="634" />
         </Paths>
       </Formula>
-      <Formula id="Individual_PKSim.PARAM_Vf (extracellular water)-RR_LiverZone" name="PARAM_Vf (extracellular water)-RR_LiverZone" formula="Liver_Parameter">
+      <Formula id="Individual_PKSim.PARAM_Vf (protein)-WS_LiverZone" name="PARAM_Vf (protein)-WS_LiverZone" formula="Liver_Parameter">
         <Paths>
-          <Path path="660" as="624" />
+          <Path path="670" as="634" />
         </Paths>
       </Formula>
-      <Formula id="Individual_PKSim.PARAM_Vf (water)-WS_LiverZone" name="PARAM_Vf (water)-WS_LiverZone" formula="Liver_Parameter">
+      <Formula id="Individual_PKSim.PARAM_Vf (intracellular water)-RR_LiverZone" name="PARAM_Vf (intracellular water)-RR_LiverZone" formula="Liver_Parameter">
         <Paths>
-          <Path path="661" as="624" />
+          <Path path="671" as="634" />
         </Paths>
       </Formula>
-      <Formula id="Individual_PKSim.PARAM_Vf (intracellular water)-RR_LiverZone" name="PARAM_Vf (intracellular water)-RR_LiverZone" formula="Liver_Parameter">
+      <Formula id="Individual_PKSim.PARAM_Vf (water)-WS_LiverZone" name="PARAM_Vf (water)-WS_LiverZone" formula="Liver_Parameter">
         <Paths>
-          <Path path="662" as="624" />
+          <Path path="672" as="634" />
         </Paths>
       </Formula>
       <Formula id="Individual_PKSim.PARAM_Acidic phospholipids [mg/g] - RR_LiverZone" name="PARAM_Acidic phospholipids [mg/g] - RR_LiverZone" formula="Liver_Parameter">
         <Paths>
-          <Path path="663" as="624" />
+          <Path path="673" as="634" />
         </Paths>
       </Formula>
       <Formula id="Individual_PKSim.PARAM_Vf (acidic phospholipids)-WS_LiverZone" name="PARAM_Vf (acidic phospholipids)-WS_LiverZone" formula="Liver_Parameter">
         <Paths>
-          <Path path="664" as="624" />
+          <Path path="674" as="634" />
         </Paths>
       </Formula>
       <Formula id="Individual_PKSim.PARAM_Specific blood flow rate_LiverZone" name="PARAM_Specific blood flow rate_LiverZone" dim="Flow per weight organ" formula="Liver_Parameter">
         <Paths>
-          <Path path="665" as="624" dim="150" />
+          <Path path="675" as="634" dim="148" />
         </Paths>
       </Formula>
       <Formula id="Individual_PKSim.PARAM_Q_from_Qspec_LiverZone" name="PARAM_Q_from_Qspec_LiverZone" dim="Flow" formula="Liver_Parameter">
         <Paths>
-          <Path path="666" as="624" dim="159" />
+          <Path path="676" as="634" dim="157" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_liv" name="PARAM_K_Water_INT_liv" formula="K_water_int">
         <Paths>
-          <Path path="667" as="181" />
+          <Path path="677" as="179" />
         </Paths>
       </Formula>
       <Formula id="Individual_PKSim.PARAM_PH_Cell_LiverZone" name="PARAM_PH_Cell_LiverZone" formula="pH_cell_Liver">
         <Paths>
-          <Path path="668" as="669" />
+          <Path path="678" as="679" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_liv" name="PARAM_K_Water_CELL_liv" formula="K_water_cell">
         <Paths>
-          <Path path="670" as="185" />
+          <Path path="680" as="183" />
         </Paths>
       </Formula>
       <Formula id="Individual_PKSim.PARAM_Volume_Pericentral" name="PARAM_Volume_Pericentral" dim="Volume" formula="V_liv * (IsLiverZonated ? 1 - f_periportal : 0)">
         <Paths>
-          <Path path="627" as="628" dim="24" />
-          <Path path="629" as="630" />
-          <Path path="631" as="632" dim="50" />
+          <Path path="637" as="638" dim="24" />
+          <Path path="639" as="640" />
+          <Path path="641" as="642" dim="55" />
         </Paths>
       </Formula>
-      <Formula id="Individual_PKSim.PARAM_Lymph_flow_rate_Liver_Pericentral" name="PARAM_Lymph_flow_rate_Liver_Pericentral" dim="Flow" formula="Q_lymph * (IsLiverZonated?  1-f_periportal : 0)">
+      <Formula id="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate_Liver_Pericentral" name="PARAM_Fluid_recirculation_flow_rate_Liver_Pericentral" dim="Flow" formula="J_iso * (IsLiverZonated?  1-f_periportal : 0)">
         <Paths>
-          <Path path="636" as="158" dim="159" />
-          <Path path="627" as="628" dim="24" />
-          <Path path="629" as="630" />
+          <Path path="644" as="645" dim="157" />
+          <Path path="637" as="638" dim="24" />
+          <Path path="639" as="640" />
         </Paths>
       </Formula>
-      <Formula id="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate_Liver_Pericentral" name="PARAM_Fluid_recirculation_flow_rate_Liver_Pericentral" dim="Flow" formula="J_iso * (IsLiverZonated?  1-f_periportal : 0)">
+      <Formula id="Individual_PKSim.PARAM_Lymph_flow_rate_Liver_Pericentral" name="PARAM_Lymph_flow_rate_Liver_Pericentral" dim="Flow" formula="Q_lymph * (IsLiverZonated?  1-f_periportal : 0)">
         <Paths>
-          <Path path="639" as="640" dim="159" />
-          <Path path="627" as="628" dim="24" />
-          <Path path="629" as="630" />
+          <Path path="648" as="156" dim="157" />
+          <Path path="637" as="638" dim="24" />
+          <Path path="639" as="640" />
         </Paths>
       </Formula>
       <Formula id="VascularEndoVolume.VOLUME_VascularEndo_liv_pericentral" name="VOLUME_VascularEndo_liv_pericentral" dim="Volume" formula="SA_pls_int*d_endo">
         <Paths>
-          <Path path="168" as="169" dim="127" />
-          <Path path="671" as="171" dim="172" />
+          <Path path="166" as="167" dim="127" />
+          <Path path="681" as="169" dim="170" />
         </Paths>
       </Formula>
       <Formula id="VascularEndoVolume.VOLUME_VascularEndo_lng" name="VOLUME_VascularEndo_lng" dim="Volume" formula="SA_pls_int*d_endo">
         <Paths>
-          <Path path="168" as="169" dim="127" />
-          <Path path="672" as="171" dim="172" />
-        </Paths>
-      </Formula>
-      <Formula id="Individual_PKSim.PARAM_Q_lng" name="PARAM_Q_lng" dim="Flow" formula="Q_sto + Q_sin + Q_lin + Q_pan + Q_spl + Q_liv + Q_mus + Q_fat + Q_skn + Q_kid + Q_brn + Q_hrt + Q_bon + Q_tes">
-        <Paths>
-          <Path path="673" as="674" dim="159" />
-          <Path path="675" as="676" dim="159" />
-          <Path path="677" as="678" dim="159" />
-          <Path path="679" as="680" dim="159" />
-          <Path path="681" as="682" dim="159" />
-          <Path path="683" as="684" dim="159" />
-          <Path path="685" as="686" dim="159" />
-          <Path path="687" as="688" dim="159" />
-          <Path path="689" as="690" dim="159" />
-          <Path path="691" as="692" dim="159" />
-          <Path path="693" as="694" dim="159" />
-          <Path path="695" as="696" dim="159" />
-          <Path path="697" as="698" dim="159" />
-          <Path path="699" as="700" dim="159" />
+          <Path path="166" as="167" dim="127" />
+          <Path path="682" as="169" dim="170" />
         </Paths>
       </Formula>
+      <SumFormula id="DynamicSumFormulas.PARAM_Q_lng" name="PARAM_Q_lng" dim="Flow" variable="Q" formulaString="Q_#i">
+        <Criteria>
+          <DescriptorConditions>
+            <InContainerCondition tag="TissueOrgan" />
+            <NotInContainerCondition tag="Lung" />
+            <NotInContainerCondition tag="Pericentral" />
+            <MatchTagCondition tag="Blood flow rate" />
+            <NotInContainerCondition tag="Mucosa" />
+          </DescriptorConditions>
+        </Criteria>
+      </SumFormula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_lng" name="PARAM_K_Water_INT_lng" formula="K_water_int">
         <Paths>
-          <Path path="701" as="181" />
+          <Path path="683" as="179" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_lng" name="PARAM_K_Water_CELL_lng" formula="K_water_cell">
         <Paths>
-          <Path path="702" as="185" />
+          <Path path="684" as="183" />
         </Paths>
       </Formula>
       <Formula id="VascularEndoVolume.VOLUME_VascularEndo_mus" name="VOLUME_VascularEndo_mus" dim="Volume" formula="SA_pls_int*d_endo">
         <Paths>
-          <Path path="168" as="169" dim="127" />
-          <Path path="703" as="171" dim="172" />
+          <Path path="166" as="167" dim="127" />
+          <Path path="685" as="169" dim="170" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_mus" name="PARAM_K_Water_INT_mus" formula="K_water_int">
         <Paths>
-          <Path path="704" as="181" />
+          <Path path="686" as="179" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_mus" name="PARAM_K_Water_CELL_mus" formula="K_water_cell">
         <Paths>
-          <Path path="705" as="185" />
+          <Path path="687" as="183" />
         </Paths>
       </Formula>
       <Formula id="VascularEndoVolume.VOLUME_VascularEndo_pan" name="VOLUME_VascularEndo_pan" dim="Volume" formula="SA_pls_int*d_endo">
         <Paths>
-          <Path path="168" as="169" dim="127" />
-          <Path path="706" as="171" dim="172" />
+          <Path path="166" as="167" dim="127" />
+          <Path path="688" as="169" dim="170" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_pan" name="PARAM_K_Water_INT_pan" formula="K_water_int">
         <Paths>
-          <Path path="707" as="181" />
+          <Path path="689" as="179" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_pan" name="PARAM_K_Water_CELL_pan" formula="K_water_cell">
         <Paths>
-          <Path path="708" as="185" />
+          <Path path="690" as="183" />
         </Paths>
       </Formula>
       <Formula id="Individual_PKSim.PARAM_Q_Lymph_pve" name="PARAM_Q_Lymph_pve" dim="Flow" formula="Q_Lymph_sto + Q_Lymph_sin_incl_Mucosa + Q_Lymph_lin_incl_Mucosa + Q_Lymph_pan + Q_Lymph_spl">
         <Paths>
-          <Path path="709" as="710" dim="159" />
-          <Path path="711" as="712" dim="159" />
-          <Path path="713" as="714" dim="159" />
-          <Path path="715" as="716" dim="159" />
-          <Path path="717" as="718" dim="159" />
+          <Path path="691" as="692" dim="157" />
+          <Path path="693" as="694" dim="157" />
+          <Path path="695" as="696" dim="157" />
+          <Path path="697" as="698" dim="157" />
+          <Path path="699" as="700" dim="157" />
         </Paths>
       </Formula>
       <Formula id="Individual_PKSim.PARAM_Q_pve" name="PARAM_Q_pve" dim="Flow" formula="Q_sto + Q_sin + Q_lin + Q_pan + Q_spl">
         <Paths>
-          <Path path="685" as="686" dim="159" />
-          <Path path="691" as="692" dim="159" />
-          <Path path="695" as="696" dim="159" />
-          <Path path="697" as="698" dim="159" />
-          <Path path="699" as="700" dim="159" />
+          <Path path="701" as="702" dim="157" />
+          <Path path="703" as="704" dim="157" />
+          <Path path="705" as="706" dim="157" />
+          <Path path="707" as="708" dim="157" />
+          <Path path="709" as="710" dim="157" />
         </Paths>
       </Formula>
       <Formula id="VascularEndoVolume.VOLUME_VascularEndo_skn" name="VOLUME_VascularEndo_skn" dim="Volume" formula="SA_pls_int*d_endo">
         <Paths>
-          <Path path="168" as="169" dim="127" />
-          <Path path="719" as="171" dim="172" />
+          <Path path="166" as="167" dim="127" />
+          <Path path="711" as="169" dim="170" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_skn" name="PARAM_K_Water_INT_skn" formula="K_water_int">
         <Paths>
-          <Path path="720" as="181" />
+          <Path path="712" as="179" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_skn" name="PARAM_K_Water_CELL_skn" formula="K_water_cell">
         <Paths>
-          <Path path="721" as="185" />
+          <Path path="713" as="183" />
         </Paths>
       </Formula>
       <Formula id="VascularEndoVolume.VOLUME_VascularEndo_spl" name="VOLUME_VascularEndo_spl" dim="Volume" formula="SA_pls_int*d_endo">
         <Paths>
-          <Path path="168" as="169" dim="127" />
-          <Path path="722" as="171" dim="172" />
+          <Path path="166" as="167" dim="127" />
+          <Path path="714" as="169" dim="170" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_spl" name="PARAM_K_Water_INT_spl" formula="K_water_int">
         <Paths>
-          <Path path="723" as="181" />
+          <Path path="715" as="179" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_spl" name="PARAM_K_Water_CELL_spl" formula="K_water_cell">
         <Paths>
-          <Path path="724" as="185" />
+          <Path path="716" as="183" />
         </Paths>
       </Formula>
       <Formula id="Individual_PKSim.VOLUME_Saliva_Organ" name="VOLUME_Saliva_Organ" dim="Volume" formula="0.006 * BW / 73">
@@ -21061,97 +21136,111 @@
       </Formula>
       <Formula id="CompartmentsVolume_4Comp.VOLUME_slv_slv" name="VOLUME_slv_slv" dim="Volume" formula="V_slv">
         <Paths>
-          <Path path="725" as="726" dim="50" />
+          <Path path="717" as="718" dim="55" />
         </Paths>
       </Formula>
       <Formula id="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls_Blood_Organ" name="PARAM_SA_rbc_pls_Blood_Organ" dim="Area" formula="HCT * A_to_V_bc * 0.6 * V">
         <Paths>
-          <Path path="727" as="138" dim="50" />
+          <Path path="719" as="138" dim="55" />
           <Path path="40" as="41" />
-          <Path path="728" as="729" dim="338" />
+          <Path path="720" as="721" dim="366" />
         </Paths>
       </Formula>
-      <Formula id="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" name="PARAM_SA_rbc_pls" dim="Area" formula="HCT * A_to_V_bc * 0.6 * V * f_vas">
+      <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_bon" name="PARAM_SA_int_cell_bon" dim="Area" formula="(V_bon * 1000 / 28.2)^0.75 * 10 * 1E2">
         <Paths>
-          <Path path="730" as="136" />
-          <Path path="727" as="138" dim="50" />
-          <Path path="40" as="41" />
-          <Path path="728" as="729" dim="338" />
+          <Path path="719" as="722" dim="55" />
         </Paths>
       </Formula>
-      <Formula id="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" name="PARAM_SA_pls_int" dim="Area" formula="k * f_vas_org * V_org">
+      <Formula id="DiffusionCommon_PKSim.PARAM_P_int_cell" name="PARAM_P_int_cell" dim="Velocity" formula="P * P_int_cell_factor">
         <Paths>
-          <Path path="730" as="731" />
-          <Path path="727" as="176" dim="50" />
-          <Path path="732" as="342" dim="338" />
+          <Path path="723" as="724" />
+          <Path path="14" as="15" dim="2" />
         </Paths>
       </Formula>
-      <BlackBoxFormula id="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" name="INTERSTITIAL PARTITION COEFFICIENT FORMULA" />
-      <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_bon" name="PARAM_SA_int_cell_bon" dim="Area" formula="(V_bon * 1000 / 28.2)^0.75 * 10 * 1E2">
+      <Formula id="DiffusionCommon_PKSim.PARAM_P_cell_int" name="PARAM_P_cell_int" dim="Velocity" formula="P * P_cell_int_factor">
+        <Paths>
+          <Path path="725" as="726" />
+          <Path path="14" as="15" dim="2" />
+        </Paths>
+      </Formula>
+      <Formula id="DiffusionCommon_PKSim.PARAM_PA_int_cell" name="PARAM_PA_int_cell" dim="Flow" formula="P_int_cell * SA">
         <Paths>
-          <Path path="727" as="733" dim="50" />
+          <Path path="727" as="728" dim="2" />
+          <Path path="729" as="730" dim="170" />
         </Paths>
       </Formula>
       <Formula id="DiffusionCommon_PKSim.PARAM_PA_cell_int" name="PARAM_PA_cell_int" dim="Flow" formula="P_cell_int * SA">
         <Paths>
-          <Path path="734" as="735" dim="2" />
-          <Path path="736" as="737" dim="172" />
+          <Path path="731" as="732" dim="2" />
+          <Path path="729" as="730" dim="170" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_wat_cell" name="PARAM_K_wat_cell" formula="fu/K_cell_pls">
         <Paths>
-          <Path path="738" as="739" />
+          <Path path="733" as="734" />
           <Path path="33" as="34" dim="24" />
         </Paths>
       </Formula>
-      <Formula id="DiffusionCommon_PKSim.PARAM_PA_int_cell" name="PARAM_PA_int_cell" dim="Flow" formula="P_int_cell * SA">
+      <Formula id="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" name="PARAM_SA_rbc_pls" dim="Area" formula="HCT * A_to_V_bc * 0.6 * V * f_vas">
         <Paths>
-          <Path path="740" as="741" dim="2" />
-          <Path path="736" as="737" dim="172" />
+          <Path path="735" as="136" />
+          <Path path="719" as="138" dim="55" />
+          <Path path="40" as="41" />
+          <Path path="720" as="721" dim="366" />
         </Paths>
       </Formula>
-      <Formula id="DiffusionCommon_PKSim.PARAM_P_cell_int" name="PARAM_P_cell_int" dim="Velocity" formula="P * P_cell_int_factor">
+      <Formula id="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" name="PARAM_SA_pls_int" dim="Area" formula="k * f_vas_org * V_org">
         <Paths>
-          <Path path="742" as="743" />
-          <Path path="7" as="8" dim="2" />
+          <Path path="735" as="736" />
+          <Path path="719" as="174" dim="55" />
+          <Path path="737" as="325" dim="366" />
         </Paths>
       </Formula>
-      <Formula id="DiffusionCommon_PKSim.PARAM_P_int_cell" name="PARAM_P_int_cell" dim="Velocity" formula="P * P_int_cell_factor">
+      <BlackBoxFormula id="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" name="INTERSTITIAL PARTITION COEFFICIENT FORMULA" />
+      <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_brn" name="PARAM_SA_int_cell_brn" dim="Area" formula="(V_brn  * 1000 / 1.671)^0.75 * 0.0006 * 1E2">
         <Paths>
-          <Path path="744" as="745" />
-          <Path path="7" as="8" dim="2" />
+          <Path path="719" as="738" dim="55" />
         </Paths>
       </Formula>
       <Formula id="DiffusionPlasma_PKSim.PARAM_P_endothelial_Brain" name="PARAM_P_endothelial_Brain" dim="Velocity" formula="P/2">
         <Paths>
-          <Path path="7" as="8" dim="2" />
-        </Paths>
-      </Formula>
-      <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_brn" name="PARAM_SA_int_cell_brn" dim="Area" formula="(V_brn  * 1000 / 1.671)^0.75 * 0.0006 * 1E2">
-        <Paths>
-          <Path path="727" as="746" dim="50" />
+          <Path path="14" as="15" dim="2" />
         </Paths>
       </Formula>
       <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_fat" name="PARAM_SA_int_cell_fat" dim="Area" formula="(V_fat * 1000 / 14.2)^0.75 * 5 * 1E2">
         <Paths>
-          <Path path="727" as="747" dim="50" />
+          <Path path="719" as="739" dim="55" />
         </Paths>
       </Formula>
       <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_tes" name="PARAM_SA_int_cell_tes" dim="Area" formula="(V_tes * 1000 / 2.5)^0.75 * 2 * 1E2">
         <Paths>
-          <Path path="727" as="748" dim="50" />
+          <Path path="719" as="740" dim="55" />
         </Paths>
       </Formula>
       <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_hrt" name="PARAM_SA_int_cell_hrt" dim="Area" formula="(V_hrt * 1000 / 1.2)^0.75 * 7.54 * 1E2">
         <Paths>
-          <Path path="727" as="749" dim="50" />
+          <Path path="719" as="741" dim="55" />
         </Paths>
       </Formula>
-      <Formula id="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPvePlasma" name="PARAM_MassTransferMucosaToPvePlasma" dim="Amount per time" formula="Q*(1-HCT)*C_pls">
+      <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_kid" name="PARAM_SA_int_cell_kid" dim="Area" formula="(V_kid * 1000 / 7)^0.75 * 1000 * 1E2">
         <Paths>
-          <Path path="750" as="751" dim="752" />
-          <Path path="753" as="165" dim="159" />
-          <Path path="40" as="41" />
+          <Path path="719" as="742" dim="55" />
+        </Paths>
+      </Formula>
+      <Formula id="DistributionCommon_PKSim.PARAM_K_water_cell_Kidney" name="PARAM_K_water_cell_Kidney" formula="K_water_cell">
+        <Paths>
+          <Path path="226" as="183" />
+        </Paths>
+      </Formula>
+      <Formula id="Lumen_PKSim.PARAM_DrugAbsorption_para" name="PARAM_DrugAbsorption_para" dim="Amount per time" formula="OralApplicationsEnabled ? P_int_para*Aeff*(EffectiveLumenConcentration-(NOT SinkCondition_para ? fu*DrugMucosa : 0)) : 0">
+        <Paths>
+          <Path path="743" as="744" dim="170" />
+          <Path path="745" as="746" dim="747" />
+          <Path path="748" as="749" dim="747" />
+          <Path path="33" as="34" dim="24" />
+          <Path path="750" as="751" dim="2" />
+          <Path path="752" as="248" />
+          <Path path="753" as="754" />
         </Paths>
       </Formula>
       <SumFormula id="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" name="PARAM_SumOfActiveProcessRates" dim="Amount per time" variable="P" formulaString="P_#i">
@@ -21164,13 +21253,6 @@
           </DescriptorConditions>
         </Criteria>
       </SumFormula>
-      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K8" name="PARAM_pKa_pH_WS_lum_K8" formula="(1-F1)*(1-F2)*(1-F3)">
-        <Paths>
-          <Path path="260" as="261" />
-          <Path path="262" as="263" />
-          <Path path="264" as="265" />
-        </Paths>
-      </Formula>
       <SumFormula id="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" name="PARAM_SumOfPassiveProcessRates" dim="Amount per time" variable="P" formulaString="P_#i">
         <Criteria>
           <DescriptorConditions>
@@ -21181,1096 +21263,1083 @@
           </DescriptorConditions>
         </Criteria>
       </SumFormula>
-      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F2" name="PARAM_pKa_pH_WS_lum_F2" formula="CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1">
+      <Formula id="Lumen_PKSim.PARAM_DrugAbsorption_trans" name="PARAM_DrugAbsorption_trans" dim="Amount per time" formula="OralApplicationsEnabled ? P_int_trans*Aeff*(P_int_trans_lum_cell_factor*EffectiveLumenConcentration-(NOT SinkCondition_trans ? P_int_trans_cell_lum_factor*fu/K_cell_pls*DrugMucosa : 0)) : 0">
         <Paths>
-          <Path path="754" as="274" />
-          <Path path="275" as="276" />
-          <Path path="269" as="270" />
-          <Path path="277" as="278" />
+          <Path path="733" as="734" />
+          <Path path="743" as="744" dim="170" />
+          <Path path="745" as="746" dim="747" />
+          <Path path="748" as="749" dim="747" />
+          <Path path="33" as="34" dim="24" />
+          <Path path="755" as="11" dim="2" />
+          <Path path="756" as="757" />
+          <Path path="758" as="759" />
+          <Path path="752" as="248" />
+          <Path path="760" as="761" />
         </Paths>
       </Formula>
-      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F3" name="PARAM_pKa_pH_WS_mucosacell_F3" formula="CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1">
+      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_cell_lum_factor" name="PARAM_P_int_trans_cell_lum_factor" formula="UsePenaltyFactor ? K1+ (K2 +K3 +K4)* base ^ 1 + K5* base ^ max(CT0+CT1;-CT0-CT1) +K6* base ^ max(CT0+CT2;-CT0-CT2) +K7* base ^ max(CT2+CT1;-CT2-CT1) +K8* base ^ max(CT0+CT1+CT2;-CT0-CT1-CT2) : 1">
         <Paths>
-          <Path path="279" as="280" />
+          <Path path="762" as="296" />
+          <Path path="763" as="298" />
+          <Path path="764" as="300" />
+          <Path path="765" as="302" />
+          <Path path="766" as="304" />
+          <Path path="767" as="306" />
+          <Path path="768" as="308" />
+          <Path path="769" as="310" />
+          <Path path="263" as="264" />
           <Path path="269" as="270" />
-          <Path path="281" as="282" />
-          <Path path="755" as="274" />
+          <Path path="273" as="274" />
+          <Path path="770" as="771" />
+          <Path path="772" as="312" />
         </Paths>
       </Formula>
-      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K1" name="PARAM_pKa_pH_WS_mucosacell_K1" formula="F1*F2*F3">
+      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_lum_cell_factor" name="PARAM_P_int_trans_lum_cell_factor" formula="UsePenaltyFactor ? K1+ (K2 +K3 +K4)* base ^ 1 + K5* base ^ max(CT0+CT1;-CT0-CT1) +K6* base ^ max(CT0+CT2;-CT0-CT2) +K7* base ^ max(CT2+CT1;-CT2-CT1) +K8* base ^ max(CT0+CT1+CT2;-CT0-CT1-CT2) : 1">
         <Paths>
-          <Path path="756" as="261" />
-          <Path path="757" as="263" />
-          <Path path="758" as="265" />
+          <Path path="295" as="296" />
+          <Path path="297" as="298" />
+          <Path path="299" as="300" />
+          <Path path="301" as="302" />
+          <Path path="303" as="304" />
+          <Path path="305" as="306" />
+          <Path path="307" as="308" />
+          <Path path="309" as="310" />
+          <Path path="263" as="264" />
+          <Path path="269" as="270" />
+          <Path path="273" as="274" />
+          <Path path="770" as="771" />
+          <Path path="772" as="312" />
         </Paths>
       </Formula>
-      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K2" name="PARAM_pKa_pH_WS_mucosacell_K2" formula="(1-F1)*F2*F3">
+      <Formula id="Lumen_PKSim.PARAM_K_cell_pls_UpperJejunum" name="PARAM_K_cell_pls_UpperJejunum" formula="K_cell_pls">
         <Paths>
-          <Path path="756" as="261" />
-          <Path path="757" as="263" />
-          <Path path="758" as="265" />
+          <Path path="773" as="734" />
         </Paths>
       </Formula>
-      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K3" name="PARAM_pKa_pH_WS_mucosacell_K3" formula="F1*(1-F2)*F3">
+      <Formula id="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_UpperJejunum" name="PARAM_K_wat_cell_Lumen_UpperJejunum" formula="K_water_cell">
         <Paths>
-          <Path path="756" as="261" />
-          <Path path="757" as="263" />
-          <Path path="758" as="265" />
+          <Path path="552" as="183" />
         </Paths>
       </Formula>
-      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K4" name="PARAM_pKa_pH_WS_mucosacell_K4" formula="F1*F2*(1-F3)">
+      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F1" name="PARAM_pKa_pH_WS_mucosacell_F1" formula="CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1">
         <Paths>
-          <Path path="756" as="261" />
-          <Path path="757" as="263" />
-          <Path path="758" as="265" />
+          <Path path="261" as="262" />
+          <Path path="263" as="264" />
+          <Path path="265" as="266" />
+          <Path path="774" as="268" />
         </Paths>
       </Formula>
-      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K5" name="PARAM_pKa_pH_WS_mucosacell_K5" formula="(1-F1)*(1-F2)*F3">
+      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F2" name="PARAM_pKa_pH_WS_mucosacell_F2" formula="CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1">
         <Paths>
-          <Path path="756" as="261" />
-          <Path path="757" as="263" />
-          <Path path="758" as="265" />
+          <Path path="261" as="262" />
+          <Path path="269" as="270" />
+          <Path path="271" as="272" />
+          <Path path="774" as="268" />
         </Paths>
       </Formula>
-      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K6" name="PARAM_pKa_pH_WS_mucosacell_K6" formula="(1-F1)*F2*(1-F3)">
+      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F3" name="PARAM_pKa_pH_WS_mucosacell_F3" formula="CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1">
         <Paths>
-          <Path path="756" as="261" />
-          <Path path="757" as="263" />
-          <Path path="758" as="265" />
+          <Path path="261" as="262" />
+          <Path path="273" as="274" />
+          <Path path="275" as="276" />
+          <Path path="774" as="268" />
         </Paths>
       </Formula>
-      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K7" name="PARAM_pKa_pH_WS_mucosacell_K7" formula="F1*(1-F2)*(1-F3)">
+      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K1" name="PARAM_pKa_pH_WS_mucosacell_K1" formula="F1*F2*F3">
         <Paths>
-          <Path path="756" as="261" />
-          <Path path="757" as="263" />
-          <Path path="758" as="265" />
+          <Path path="775" as="278" />
+          <Path path="776" as="280" />
+          <Path path="777" as="282" />
         </Paths>
       </Formula>
-      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F1" name="PARAM_pKa_pH_WS_lum_F1" formula="CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1">
+      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K2" name="PARAM_pKa_pH_WS_mucosacell_K2" formula="(1-F1)*F2*F3">
         <Paths>
-          <Path path="754" as="274" />
-          <Path path="267" as="268" />
-          <Path path="269" as="270" />
-          <Path path="271" as="272" />
+          <Path path="775" as="278" />
+          <Path path="776" as="280" />
+          <Path path="777" as="282" />
         </Paths>
       </Formula>
-      <Formula id="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_UpperJejunum" name="PARAM_K_wat_cell_Lumen_UpperJejunum" formula="K_water_cell">
+      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K3" name="PARAM_pKa_pH_WS_mucosacell_K3" formula="F1*(1-F2)*F3">
         <Paths>
-          <Path path="542" as="185" />
+          <Path path="775" as="278" />
+          <Path path="776" as="280" />
+          <Path path="777" as="282" />
         </Paths>
       </Formula>
-      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F3" name="PARAM_pKa_pH_WS_lum_F3" formula="CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1">
+      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K4" name="PARAM_pKa_pH_WS_mucosacell_K4" formula="F1*F2*(1-F3)">
         <Paths>
-          <Path path="754" as="274" />
-          <Path path="279" as="280" />
-          <Path path="269" as="270" />
-          <Path path="281" as="282" />
+          <Path path="775" as="278" />
+          <Path path="776" as="280" />
+          <Path path="777" as="282" />
         </Paths>
       </Formula>
-      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K1" name="PARAM_pKa_pH_WS_lum_K1" formula="F1*F2*F3">
+      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K5" name="PARAM_pKa_pH_WS_mucosacell_K5" formula="(1-F1)*(1-F2)*F3">
         <Paths>
-          <Path path="260" as="261" />
-          <Path path="262" as="263" />
-          <Path path="264" as="265" />
+          <Path path="775" as="278" />
+          <Path path="776" as="280" />
+          <Path path="777" as="282" />
         </Paths>
       </Formula>
-      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K2" name="PARAM_pKa_pH_WS_lum_K2" formula="(1-F1)*F2*F3">
+      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K6" name="PARAM_pKa_pH_WS_mucosacell_K6" formula="(1-F1)*F2*(1-F3)">
         <Paths>
-          <Path path="260" as="261" />
-          <Path path="262" as="263" />
-          <Path path="264" as="265" />
+          <Path path="775" as="278" />
+          <Path path="776" as="280" />
+          <Path path="777" as="282" />
         </Paths>
       </Formula>
-      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K3" name="PARAM_pKa_pH_WS_lum_K3" formula="F1*(1-F2)*F3">
+      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K7" name="PARAM_pKa_pH_WS_mucosacell_K7" formula="F1*(1-F2)*(1-F3)">
         <Paths>
-          <Path path="260" as="261" />
-          <Path path="262" as="263" />
-          <Path path="264" as="265" />
+          <Path path="775" as="278" />
+          <Path path="776" as="280" />
+          <Path path="777" as="282" />
         </Paths>
       </Formula>
-      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K4" name="PARAM_pKa_pH_WS_lum_K4" formula="F1*F2*(1-F3)">
+      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K8" name="PARAM_pKa_pH_WS_mucosacell_K8" formula="(1-F1)*(1-F2)*(1-F3)">
         <Paths>
-          <Path path="260" as="261" />
-          <Path path="262" as="263" />
-          <Path path="264" as="265" />
+          <Path path="775" as="278" />
+          <Path path="776" as="280" />
+          <Path path="777" as="282" />
         </Paths>
       </Formula>
-      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K5" name="PARAM_pKa_pH_WS_lum_K5" formula="(1-F1)*(1-F2)*F3">
+      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F1" name="PARAM_pKa_pH_WS_lum_F1" formula="CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1">
         <Paths>
-          <Path path="260" as="261" />
-          <Path path="262" as="263" />
-          <Path path="264" as="265" />
+          <Path path="778" as="268" />
+          <Path path="261" as="262" />
+          <Path path="263" as="264" />
+          <Path path="265" as="266" />
         </Paths>
       </Formula>
-      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K6" name="PARAM_pKa_pH_WS_lum_K6" formula="(1-F1)*F2*(1-F3)">
+      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F2" name="PARAM_pKa_pH_WS_lum_F2" formula="CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1">
         <Paths>
-          <Path path="260" as="261" />
-          <Path path="262" as="263" />
-          <Path path="264" as="265" />
+          <Path path="778" as="268" />
+          <Path path="261" as="262" />
+          <Path path="269" as="270" />
+          <Path path="271" as="272" />
         </Paths>
       </Formula>
-      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K7" name="PARAM_pKa_pH_WS_lum_K7" formula="F1*(1-F2)*(1-F3)">
+      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F3" name="PARAM_pKa_pH_WS_lum_F3" formula="CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1">
         <Paths>
-          <Path path="260" as="261" />
-          <Path path="262" as="263" />
-          <Path path="264" as="265" />
+          <Path path="778" as="268" />
+          <Path path="261" as="262" />
+          <Path path="273" as="274" />
+          <Path path="275" as="276" />
         </Paths>
       </Formula>
-      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K8" name="PARAM_pKa_pH_WS_mucosacell_K8" formula="(1-F1)*(1-F2)*(1-F3)">
+      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K1" name="PARAM_pKa_pH_WS_lum_K1" formula="F1*F2*F3">
         <Paths>
-          <Path path="756" as="261" />
-          <Path path="757" as="263" />
-          <Path path="758" as="265" />
+          <Path path="277" as="278" />
+          <Path path="279" as="280" />
+          <Path path="281" as="282" />
         </Paths>
       </Formula>
-      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F2" name="PARAM_pKa_pH_WS_mucosacell_F2" formula="CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1">
+      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K2" name="PARAM_pKa_pH_WS_lum_K2" formula="(1-F1)*F2*F3">
         <Paths>
-          <Path path="275" as="276" />
-          <Path path="269" as="270" />
           <Path path="277" as="278" />
-          <Path path="755" as="274" />
+          <Path path="279" as="280" />
+          <Path path="281" as="282" />
         </Paths>
       </Formula>
-      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F1" name="PARAM_pKa_pH_WS_mucosacell_F1" formula="CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1">
+      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K3" name="PARAM_pKa_pH_WS_lum_K3" formula="F1*(1-F2)*F3">
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-          <Path path="267" as="268" />
-          <Path path="269" as="270" />
-          <Path path="271" as="272" />
-          <Path path="755" as="274" />
+          <Path path="277" as="278" />
+          <Path path="279" as="280" />
+          <Path path="281" as="282" />
         </Paths>
       </Formula>
-      <Formula id="Lumen_PKSim.PARAM_DrugAbsorption_trans" name="PARAM_DrugAbsorption_trans" dim="Amount per time" formula="OralApplicationsEnabled ? P_int_trans*Aeff*(P_int_trans_lum_cell_factor*min(Solubility/ MW ;DrugLiquid/(Liquid))-(NOT SinkCondition_trans ? P_int_trans_cell_lum_factor*fu/K_cell_pls*DrugMucosa : 0)) : 0">
+      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K4" name="PARAM_pKa_pH_WS_lum_K4" formula="F1*F2*(1-F3)">
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-          <Path path="738" as="739" />
-          <Path path="759" as="760" dim="172" />
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-          <Path path="762" as="763" dim="764" />
-          <Path path="765" as="766" dim="752" />
-          <Path path="33" as="34" dim="24" />
-          <Path path="767" as="4" dim="2" />
-          <Path path="768" as="769" dim="770" />
-          <Path path="771" as="772" />
-          <Path path="773" as="774" />
-          <Path path="775" as="289" dim="285" />
-          <Path path="776" as="248" />
-          <Path path="777" as="778" />
+          <Path path="277" as="278" />
+          <Path path="279" as="280" />
+          <Path path="281" as="282" />
         </Paths>
       </Formula>
-      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_cell_lum_factor" name="PARAM_P_int_trans_cell_lum_factor" formula="UsePenaltyFactor ? K1+ (K2 +K3 +K4)* base ^ 1 + K5* base ^ max(CT0+CT1;-CT0-CT1) +K6* base ^ max(CT0+CT2;-CT0-CT2) +K7* base ^ max(CT2+CT1;-CT2-CT1) +K8* base ^ max(CT0+CT1+CT2;-CT0-CT1-CT2) : 1">
+      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K5" name="PARAM_pKa_pH_WS_lum_K5" formula="(1-F1)*(1-F2)*F3">
         <Paths>
-          <Path path="779" as="296" />
-          <Path path="780" as="298" />
-          <Path path="781" as="300" />
-          <Path path="782" as="302" />
-          <Path path="783" as="304" />
-          <Path path="784" as="306" />
-          <Path path="785" as="308" />
-          <Path path="786" as="310" />
-          <Path path="787" as="312" />
-          <Path path="267" as="268" />
-          <Path path="275" as="276" />
+          <Path path="277" as="278" />
           <Path path="279" as="280" />
-          <Path path="788" as="789" />
+          <Path path="281" as="282" />
         </Paths>
       </Formula>
-      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_lum_cell_factor" name="PARAM_P_int_trans_lum_cell_factor" formula="UsePenaltyFactor ? K1+ (K2 +K3 +K4)* base ^ 1 + K5* base ^ max(CT0+CT1;-CT0-CT1) +K6* base ^ max(CT0+CT2;-CT0-CT2) +K7* base ^ max(CT2+CT1;-CT2-CT1) +K8* base ^ max(CT0+CT1+CT2;-CT0-CT1-CT2) : 1">
+      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K6" name="PARAM_pKa_pH_WS_lum_K6" formula="(1-F1)*F2*(1-F3)">
         <Paths>
-          <Path path="295" as="296" />
-          <Path path="297" as="298" />
-          <Path path="299" as="300" />
-          <Path path="301" as="302" />
-          <Path path="303" as="304" />
-          <Path path="305" as="306" />
-          <Path path="307" as="308" />
-          <Path path="309" as="310" />
-          <Path path="787" as="312" />
-          <Path path="267" as="268" />
-          <Path path="275" as="276" />
+          <Path path="277" as="278" />
           <Path path="279" as="280" />
-          <Path path="788" as="789" />
+          <Path path="281" as="282" />
         </Paths>
       </Formula>
-      <Formula id="Lumen_PKSim.PARAM_K_cell_pls_UpperJejunum" name="PARAM_K_cell_pls_UpperJejunum" formula="K_cell_pls">
+      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K7" name="PARAM_pKa_pH_WS_lum_K7" formula="F1*(1-F2)*(1-F3)">
         <Paths>
-          <Path path="790" as="739" />
+          <Path path="277" as="278" />
+          <Path path="279" as="280" />
+          <Path path="281" as="282" />
         </Paths>
       </Formula>
-      <Formula id="Lumen_PKSim.PARAM_DrugAbsorption_para" name="PARAM_DrugAbsorption_para" dim="Amount per time" formula="OralApplicationsEnabled ? P_int_para*Aeff*(min(Solubility/ MW ;DrugLiquid/(Liquid))-(NOT SinkCondition_para ? fu*DrugMucosa : 0)) : 0">
+      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K8" name="PARAM_pKa_pH_WS_lum_K8" formula="(1-F1)*(1-F2)*(1-F3)">
         <Paths>
-          <Path path="759" as="760" dim="172" />
-          <Path path="761" as="230" dim="50" />
-          <Path path="762" as="763" dim="764" />
-          <Path path="765" as="766" dim="752" />
-          <Path path="33" as="34" dim="24" />
-          <Path path="791" as="792" dim="2" />
-          <Path path="768" as="769" dim="770" />
-          <Path path="775" as="289" dim="285" />
-          <Path path="776" as="248" />
-          <Path path="793" as="794" />
+          <Path path="277" as="278" />
+          <Path path="279" as="280" />
+          <Path path="281" as="282" />
         </Paths>
       </Formula>
-      <Formula id="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPveBloodCells" name="PARAM_MassTransferMucosaToPveBloodCells" dim="Amount per time" formula="Q*HCT*C_bc">
+      <Formula id="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPvePlasma" name="PARAM_MassTransferMucosaToPvePlasma" dim="Amount per time" formula="Q*(1-HCT)*C_pls">
         <Paths>
-          <Path path="750" as="795" dim="752" />
-          <Path path="753" as="165" dim="159" />
+          <Path path="779" as="780" dim="747" />
+          <Path path="781" as="163" dim="157" />
           <Path path="40" as="41" />
         </Paths>
       </Formula>
-      <Formula id="DistributionCommon_PKSim.PARAM_K_water_cell_Kidney" name="PARAM_K_water_cell_Kidney" formula="K_water_cell">
-        <Paths>
-          <Path path="226" as="185" />
-        </Paths>
-      </Formula>
-      <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_kid" name="PARAM_SA_int_cell_kid" dim="Area" formula="(V_kid * 1000 / 7)^0.75 * 1000 * 1E2">
+      <Formula id="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPveBloodCells" name="PARAM_MassTransferMucosaToPveBloodCells" dim="Amount per time" formula="Q*HCT*C_bc">
         <Paths>
-          <Path path="727" as="796" dim="50" />
+          <Path path="779" as="782" dim="747" />
+          <Path path="781" as="163" dim="157" />
+          <Path path="40" as="41" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_K_cell_pls_LowerJejunum" name="PARAM_K_cell_pls_LowerJejunum" formula="K_cell_pls">
         <Paths>
-          <Path path="797" as="739" />
+          <Path path="783" as="734" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_LowerJejunum" name="PARAM_K_wat_cell_Lumen_LowerJejunum" formula="K_water_cell">
         <Paths>
-          <Path path="546" as="185" />
+          <Path path="556" as="183" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_OralMassAbsorbed" name="PARAM_OralMassAbsorbed" dim="Amount" formula="MAbs_duo + MAbs_uje + MAbs_lje + MAbs_uil + MAbs_lil + MAbs_cae + MAbs_colasc + MAbs_coltrans + MAbs_coldesc + MAbs_colsigm + MAbs_rect">
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-          <Path path="798" as="799" dim="764" />
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-          <Path path="802" as="803" dim="764" />
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-          <Path path="806" as="807" dim="764" />
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-          <Path path="814" as="815" dim="764" />
-          <Path path="816" as="817" dim="764" />
-          <Path path="818" as="819" dim="764" />
+          <Path path="784" as="785" dim="316" />
+          <Path path="786" as="787" dim="316" />
+          <Path path="788" as="789" dim="316" />
+          <Path path="790" as="791" dim="316" />
+          <Path path="792" as="793" dim="316" />
+          <Path path="794" as="795" dim="316" />
+          <Path path="796" as="797" dim="316" />
+          <Path path="798" as="799" dim="316" />
+          <Path path="800" as="801" dim="316" />
+          <Path path="802" as="803" dim="316" />
+          <Path path="804" as="805" dim="316" />
         </Paths>
       </Formula>
       <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_sto" name="PARAM_SA_int_cell_sto" dim="Area" formula="(V_sto * 1000 / 1.1)^0.75 * 1000 * 1E2">
         <Paths>
-          <Path path="727" as="820" dim="50" />
+          <Path path="719" as="806" dim="55" />
         </Paths>
       </Formula>
       <Formula id="Lumen_PKSim.PARAM_K_cell_pls_UpperIleum" name="PARAM_K_cell_pls_UpperIleum" formula="K_cell_pls">
         <Paths>
-          <Path path="821" as="739" />
+          <Path path="807" as="734" />
         </Paths>
       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_UpperIleum" name="PARAM_K_wat_cell_Lumen_UpperIleum" formula="K_water_cell">
         <Paths>
-          <Path path="550" as="185" />
+          <Path path="560" as="183" />
         </Paths>
       </Formula>
-      <Formula id="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaPlasma" name="PARAM_MassTransferIntestineToMucosaPlasma" dim="Amount per time" formula="Q*(1-HCT)*C_pls">
+      <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_sin" name="PARAM_SA_int_cell_sin" dim="Area" formula="((V_sin-V_Mucosa) * 1000 / 11.1)^0.75 * 1000 * 1E2">
         <Paths>
-          <Path path="822" as="165" dim="159" />
-          <Path path="750" as="751" dim="752" />
-          <Path path="40" as="41" />
+          <Path path="719" as="808" dim="55" />
+          <Path path="809" as="527" dim="55" />
         </Paths>
       </Formula>
-      <Formula id="Lumen_PKSim.PARAM_K_cell_pls_LowerIleum" name="PARAM_K_cell_pls_LowerIleum" formula="K_cell_pls">
+      <Formula id="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls_sinlin" name="PARAM_SA_rbc_pls_sinlin" dim="Area" formula="HCT * A_to_V_bc * 0.6 * (V-V_Mucosa) * f_vas">
         <Paths>
-          <Path path="823" as="739" />
+          <Path path="735" as="136" />
+          <Path path="719" as="138" dim="55" />
+          <Path path="810" as="527" dim="55" />
+          <Path path="40" as="41" />
+          <Path path="720" as="721" dim="366" />
         </Paths>
       </Formula>
-      <Formula id="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_LowerIleum" name="PARAM_K_wat_cell_Lumen_LowerIleum" formula="K_water_cell">
+      <Formula id="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int_sinlin" name="PARAM_SA_pls_int_sinlin" dim="Area" formula="k * f_vas_org * (V_org-V_Mucosa)">
         <Paths>
-          <Path path="554" as="185" />
+          <Path path="735" as="736" />
+          <Path path="719" as="174" dim="55" />
+          <Path path="810" as="527" dim="55" />
+          <Path path="737" as="325" dim="366" />
         </Paths>
       </Formula>
-      <Formula id="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaBloodCells" name="PARAM_MassTransferIntestineToMucosaBloodCells" dim="Amount per time" formula="Q*HCT*C_bc">
+      <Formula id="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaPlasma" name="PARAM_MassTransferIntestineToMucosaPlasma" dim="Amount per time" formula="Q*(1-HCT)*C_pls">
         <Paths>
-          <Path path="822" as="165" dim="159" />
-          <Path path="750" as="795" dim="752" />
+          <Path path="811" as="163" dim="157" />
+          <Path path="779" as="780" dim="747" />
           <Path path="40" as="41" />
         </Paths>
       </Formula>
-      <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_sin" name="PARAM_SA_int_cell_sin" dim="Area" formula="((V_sin-V_Mucosa) * 1000 / 11.1)^0.75 * 1000 * 1E2">
+      <Formula id="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaBloodCells" name="PARAM_MassTransferIntestineToMucosaBloodCells" dim="Amount per time" formula="Q*HCT*C_bc">
         <Paths>
-          <Path path="727" as="824" dim="50" />
-          <Path path="825" as="517" dim="50" />
+          <Path path="811" as="163" dim="157" />
+          <Path path="779" as="782" dim="747" />
+          <Path path="40" as="41" />
         </Paths>
       </Formula>
-      <Formula id="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls_sinlin" name="PARAM_SA_rbc_pls_sinlin" dim="Area" formula="HCT * A_to_V_bc * 0.6 * (V-V_Mucosa) * f_vas">
+      <Formula id="Lumen_PKSim.PARAM_K_cell_pls_LowerIleum" name="PARAM_K_cell_pls_LowerIleum" formula="K_cell_pls">
         <Paths>
-          <Path path="730" as="136" />
-          <Path path="727" as="138" dim="50" />
-          <Path path="826" as="517" dim="50" />
-          <Path path="40" as="41" />
-          <Path path="728" as="729" dim="338" />
+          <Path path="812" as="734" />
         </Paths>
       </Formula>
-      <Formula id="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int_sinlin" name="PARAM_SA_pls_int_sinlin" dim="Area" formula="k * f_vas_org * (V_org-V_Mucosa)">
+      <Formula id="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_LowerIleum" name="PARAM_K_wat_cell_Lumen_LowerIleum" formula="K_water_cell">
         <Paths>
-          <Path path="730" as="731" />
-          <Path path="727" as="176" dim="50" />
-          <Path path="826" as="517" dim="50" />
-          <Path path="732" as="342" dim="338" />
+          <Path path="564" as="183" />
         </Paths>
       </Formula>
       <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_lin" name="PARAM_SA_int_cell_lin" dim="Area" formula="((V_lin-V_Mucosa) * 1000 / 11.1)^0.75 * 1000 * 1E2">
         <Paths>
-          <Path path="727" as="827" dim="50" />
-          <Path path="828" as="517" dim="50" />
+          <Path path="719" as="813" dim="55" />
+          <Path path="814" as="527" dim="55" />
         </Paths>
       </Formula>
       <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_liv" name="PARAM_SA_int_cell_liv" dim="Area" formula="(V_liv * 1000 / 10)^0.75 * 82 * 1E2">
         <Paths>
-          <Path path="727" as="632" dim="50" />
+          <Path path="719" as="642" dim="55" />
         </Paths>
       </Formula>
       <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_periportal" name="PARAM_SA_int_cell_periportal" dim="Area" formula="SA_int_cell * (IsLiverZonated?  f_periportal : 1)">
         <Paths>
-          <Path path="627" as="628" dim="24" />
-          <Path path="629" as="630" />
-          <Path path="829" as="830" dim="172" />
+          <Path path="637" as="638" dim="24" />
+          <Path path="639" as="640" />
+          <Path path="815" as="816" dim="170" />
         </Paths>
       </Formula>
       <Formula id="SurfaceAreaRbcPls_PKSim.PARAM_SA_pls_bc_periportal" name="PARAM_SA_pls_bc_periportal" dim="Area" formula="SA_pls_bc * (IsLiverZonated?  f_periportal : 1)">
         <Paths>
-          <Path path="627" as="628" dim="24" />
-          <Path path="629" as="630" />
-          <Path path="831" as="832" dim="172" />
+          <Path path="637" as="638" dim="24" />
+          <Path path="639" as="640" />
+          <Path path="817" as="818" dim="170" />
         </Paths>
       </Formula>
       <Formula id="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int_periportal" name="PARAM_SA_pls_int_periportal" dim="Area" formula="SA_pls_int * (IsLiverZonated?  f_periportal : 1)">
         <Paths>
-          <Path path="627" as="628" dim="24" />
-          <Path path="629" as="630" />
-          <Path path="622" as="171" dim="172" />
+          <Path path="637" as="638" dim="24" />
+          <Path path="639" as="640" />
+          <Path path="632" as="169" dim="170" />
         </Paths>
       </Formula>
-      <Formula id="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int_pericentral" name="PARAM_SA_pls_int_pericentral" dim="Area" formula="SA_pls_int * (IsLiverZonated?  1-f_periportal : 0)">
+      <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_pericentral" name="PARAM_SA_int_cell_pericentral" dim="Area" formula="SA_int_cell * (IsLiverZonated?  1-f_periportal : 0)">
         <Paths>
-          <Path path="627" as="628" dim="24" />
-          <Path path="629" as="630" />
-          <Path path="622" as="171" dim="172" />
+          <Path path="637" as="638" dim="24" />
+          <Path path="639" as="640" />
+          <Path path="815" as="816" dim="170" />
         </Paths>
       </Formula>
       <Formula id="SurfaceAreaRbcPls_PKSim.PARAM_SA_pls_bc_pericentral" name="PARAM_SA_pls_bc_pericentral" dim="Area" formula="SA_pls_bc * (IsLiverZonated?  1-f_periportal : 0)">
         <Paths>
-          <Path path="627" as="628" dim="24" />
-          <Path path="629" as="630" />
-          <Path path="831" as="832" dim="172" />
+          <Path path="637" as="638" dim="24" />
+          <Path path="639" as="640" />
+          <Path path="817" as="818" dim="170" />
         </Paths>
       </Formula>
-      <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_pericentral" name="PARAM_SA_int_cell_pericentral" dim="Area" formula="SA_int_cell * (IsLiverZonated?  1-f_periportal : 0)">
+      <Formula id="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int_pericentral" name="PARAM_SA_pls_int_pericentral" dim="Area" formula="SA_pls_int * (IsLiverZonated?  1-f_periportal : 0)">
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       <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mucosa_colasc" name="PARAM_SA_int_cell_mucosa_colasc" dim="Area" formula="Aeff / MicrovilliFactor">
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       <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mucosa_coltrans" name="PARAM_SA_int_cell_mucosa_coltrans" dim="Area" formula="Aeff / MicrovilliFactor">
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       <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mucosa_coldesc" name="PARAM_SA_int_cell_mucosa_coldesc" dim="Area" formula="Aeff / MicrovilliFactor">
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       <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mucosa_colsigm" name="PARAM_SA_int_cell_mucosa_colsigm" dim="Area" formula="Aeff / MicrovilliFactor">
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-          <Path path="866" as="760" dim="172" />
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+          <Path path="852" as="744" dim="170" />
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       <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mucosa_rect" name="PARAM_SA_int_cell_mucosa_rect" dim="Area" formula="Aeff / MicrovilliFactor">
         <Paths>
-          <Path path="868" as="760" dim="172" />
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+          <Path path="854" as="744" dim="170" />
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       </Formula>
-      <Formula id="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_Duodenum" name="PARAM_K_wat_cell_Lumen_Duodenum" formula="K_water_cell">
+      <Formula id="Lumen_PKSim.PARAM_K_cell_pls_Duodenum" name="PARAM_K_cell_pls_Duodenum" formula="K_cell_pls">
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-          <Path path="538" as="185" />
+          <Path path="856" as="734" />
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       </Formula>
-      <Formula id="Lumen_PKSim.PARAM_K_cell_pls_Duodenum" name="PARAM_K_cell_pls_Duodenum" formula="K_cell_pls">
+      <Formula id="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_Duodenum" name="PARAM_K_wat_cell_Lumen_Duodenum" formula="K_water_cell">
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-          <Path path="870" as="739" />
+          <Path path="548" as="183" />
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       <Formula id="Lumen_PKSim.PARAM_K_cell_pls_Caecum" name="PARAM_K_cell_pls_Caecum" formula="K_cell_pls">
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-          <Path path="871" as="739" />
+          <Path path="857" as="734" />
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       </Formula>
       <Formula id="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_Caecum" name="PARAM_K_wat_cell_Lumen_Caecum" formula="K_water_cell">
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-          <Path path="601" as="185" />
+          <Path path="611" as="183" />
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       </Formula>
-      <Formula id="Lumen_PKSim.PARAM_K_cell_pls_ColonDescendens" name="PARAM_K_cell_pls_ColonDescendens" formula="K_cell_pls">
+      <Formula id="Lumen_PKSim.PARAM_K_cell_pls_ColonAscendens" name="PARAM_K_cell_pls_ColonAscendens" formula="K_cell_pls">
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-          <Path path="872" as="739" />
+          <Path path="858" as="734" />
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-      <Formula id="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_ColonDescendens" name="PARAM_K_wat_cell_Lumen_ColonDescendens" formula="K_water_cell">
+      <Formula id="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_ColonAscendens" name="PARAM_K_wat_cell_Lumen_ColonAscendens" formula="K_water_cell">
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-          <Path path="613" as="185" />
+          <Path path="615" as="183" />
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       <Formula id="Lumen_PKSim.PARAM_K_cell_pls_ColonTransversum" name="PARAM_K_cell_pls_ColonTransversum" formula="K_cell_pls">
         <Paths>
-          <Path path="873" as="739" />
+          <Path path="859" as="734" />
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       <Formula id="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_ColonTransversum" name="PARAM_K_wat_cell_Lumen_ColonTransversum" formula="K_water_cell">
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-          <Path path="609" as="185" />
+          <Path path="619" as="183" />
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-      <Formula id="Lumen_PKSim.PARAM_K_cell_pls_ColonSigmoid" name="PARAM_K_cell_pls_ColonSigmoid" formula="K_cell_pls">
+      <Formula id="Lumen_PKSim.PARAM_K_cell_pls_ColonDescendens" name="PARAM_K_cell_pls_ColonDescendens" formula="K_cell_pls">
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-          <Path path="874" as="739" />
+          <Path path="860" as="734" />
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-      <Formula id="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_ColonSigmoid" name="PARAM_K_wat_cell_Lumen_ColonSigmoid" formula="K_water_cell">
+      <Formula id="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_ColonDescendens" name="PARAM_K_wat_cell_Lumen_ColonDescendens" formula="K_water_cell">
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-          <Path path="617" as="185" />
+          <Path path="623" as="183" />
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-      <Formula id="Lumen_PKSim.PARAM_K_cell_pls_ColonAscendens" name="PARAM_K_cell_pls_ColonAscendens" formula="K_cell_pls">
+      <Formula id="Lumen_PKSim.PARAM_K_cell_pls_ColonSigmoid" name="PARAM_K_cell_pls_ColonSigmoid" formula="K_cell_pls">
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-          <Path path="875" as="739" />
+          <Path path="861" as="734" />
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-      <Formula id="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_ColonAscendens" name="PARAM_K_wat_cell_Lumen_ColonAscendens" formula="K_water_cell">
+      <Formula id="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_ColonSigmoid" name="PARAM_K_wat_cell_Lumen_ColonSigmoid" formula="K_water_cell">
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+      <NormalDistributionFormula id="6PHGcrkAq0GRMhtC6-vfvA" dim="Mass">
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+      <NormalDistributionFormula id="mwtm2Qi1XEyjHG7Sa6fLyA" dim="Length">
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-      <NormalDistributionFormula id="LOUb7Nu_ZU276rqFY5Zf-A" dim="Flow per weight organ">
+      <NormalDistributionFormula id="Loi32up8uU20Pl7VB-bUAw" dim="Flow per weight organ">
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+      <NormalDistributionFormula id="eSz7_AoOhEWhZCwvten5VA" dim="Flow per weight organ">
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+      <LogNormalDistributionFormula id="JaBYEYPSaEWA8RAcvU3lgg" dim="Volume">
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+      <NormalDistributionFormula id="-pUbyH623kuGtdr88f7jAA" dim="Flow per weight organ">
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+      <NormalDistributionFormula id="XF6VqRoIkkuzd3fh-8yz_w" dim="Volume">
         <Paths>
-          <Path path="876" as="876" dim="50" />
-          <Path path="877" as="877" dim="50" />
+          <Path path="862" as="862" dim="55" />
+          <Path path="863" as="863" dim="55" />
         </Paths>
       </NormalDistributionFormula>
-      <NormalDistributionFormula id="smgcZtEOdUOGNm9f8W8gZQ" dim="Flow per weight organ">
+      <NormalDistributionFormula id="bFWLRN-OXkaL-julBEoH_A" dim="Flow per weight organ">
         <Paths>
-          <Path path="876" as="876" dim="150" />
-          <Path path="877" as="877" dim="150" />
+          <Path path="862" as="862" dim="148" />
+          <Path path="863" as="863" dim="148" />
         </Paths>
       </NormalDistributionFormula>
-      <NormalDistributionFormula id="U2Rue_V_pE-3LNsSAORIzg" dim="Volume">
+      <NormalDistributionFormula id="zwnI8wyQcki3_651Q0hVug" dim="Volume">
         <Paths>
-          <Path path="876" as="876" dim="50" />
-          <Path path="877" as="877" dim="50" />
+          <Path path="862" as="862" dim="55" />
+          <Path path="863" as="863" dim="55" />
         </Paths>
       </NormalDistributionFormula>
-      <NormalDistributionFormula id="ci526B1ATUmnybUZ4PnGBg" dim="Volume">
+      <NormalDistributionFormula id="FjypwMZc50y6Nb-umu-Anw" dim="Volume">
         <Paths>
-          <Path path="876" as="876" dim="50" />
-          <Path path="877" as="877" dim="50" />
+          <Path path="862" as="862" dim="55" />
+          <Path path="863" as="863" dim="55" />
         </Paths>
       </NormalDistributionFormula>
-      <NormalDistributionFormula id="tehHGmUYm0mMGJG39qPiXg" dim="Flow per weight organ">
+      <NormalDistributionFormula id="Jpe1tZzbBkeToxaQD6it7Q" dim="Flow per weight organ">
         <Paths>
-          <Path path="876" as="876" dim="150" />
-          <Path path="877" as="877" dim="150" />
+          <Path path="862" as="862" dim="148" />
+          <Path path="863" as="863" dim="148" />
         </Paths>
       </NormalDistributionFormula>
-      <LogNormalDistributionFormula id="zytU3pZxt0yzrY53V7RxJA" dim="Volume">
+      <LogNormalDistributionFormula id="PW8iXUMul0m-HsDTwcZiwQ" dim="Volume">
         <Paths>
-          <Path path="876" as="876" dim="50" />
-          <Path path="878" as="878" />
+          <Path path="862" as="862" dim="55" />
+          <Path path="864" as="864" />
         </Paths>
       </LogNormalDistributionFormula>
-      <NormalDistributionFormula id="WffFrC6JzE2Iu2w6lBD6SA" dim="Flow per weight organ">
+      <NormalDistributionFormula id="IY6JtcbS3UKE27X9r4NEUw" dim="Flow per weight organ">
         <Paths>
-          <Path path="876" as="876" dim="150" />
-          <Path path="877" as="877" dim="150" />
+          <Path path="862" as="862" dim="148" />
+          <Path path="863" as="863" dim="148" />
         </Paths>
       </NormalDistributionFormula>
     </Formulas>
     <StringMap>
-      <Map s="..|Default Intestinal permeability (transcellular)" id="0" />
-      <Map s="P_int_trans_default" id="1" />
+      <Map s="MOLECULE|Calculated specific intestinal permeability (transcellular)" id="0" />
+      <Map s="P_int_InVitro" id="1" />
       <Map s="Velocity" id="2" />
-      <Map s="..|Intestinal permeability (transcellular)" id="3" />
-      <Map s="P_int_trans" id="4" />
-      <Map s="MOLECULE|P_bc_pls_factor" id="5" />
-      <Map s="P_rbc_pls_factor" id="6" />
-      <Map s="MOLECULE|Permeability" id="7" />
-      <Map s="P" id="8" />
-      <Map s="MOLECULE|Parameter b for correlation of intestinal permeability (transcellular)" id="9" />
-      <Map s="b" id="10" />
-      <Map s="MOLECULE|Parameter m for correlation of intestinal permeability (transcellular)" id="11" />
-      <Map s="m" id="12" />
-      <Map s="MOLECULE|Specific intestinal permeability (transcellular)" id="13" />
-      <Map s="P_int_InVitro" id="14" />
-      <Map s="MOLECULE|Calculated specific intestinal permeability (transcellular)" id="15" />
+      <Map s="MOLECULE|Parameter b for correlation of intestinal permeability (transcellular)" id="3" />
+      <Map s="b" id="4" />
+      <Map s="MOLECULE|Parameter m for correlation of intestinal permeability (transcellular)" id="5" />
+      <Map s="m" id="6" />
+      <Map s="MOLECULE|Specific intestinal permeability (transcellular)" id="7" />
+      <Map s="..|Default Intestinal permeability (transcellular)" id="8" />
+      <Map s="P_int_trans_default" id="9" />
+      <Map s="..|Intestinal permeability (transcellular)" id="10" />
+      <Map s="P_int_trans" id="11" />
+      <Map s="MOLECULE|P_bc_pls_factor" id="12" />
+      <Map s="P_rbc_pls_factor" id="13" />
+      <Map s="MOLECULE|Permeability" id="14" />
+      <Map s="P" id="15" />
       <Map s="MOLECULE|P_pls_bc_factor" id="16" />
       <Map s="P_pls_rbc_factor" id="17" />
       <Map s="..|BP_AGP" id="18" />
@@ -22303,72 +22372,72 @@
       <Map s="f_proteins_rbc" id="45" />
       <Map s="Organism|Vf (water,blood cells)" id="46" />
       <Map s="f_water_rbc" id="47" />
-      <Map s="Organism|ArterialBlood|Plasma|Volume" id="48" />
-      <Map s="V_pls_art" id="49" />
-      <Map s="Volume" id="50" />
-      <Map s="Organism|Bone|Plasma|Volume" id="51" />
-      <Map s="V_pls_bon" id="52" />
-      <Map s="Organism|Brain|Plasma|Volume" id="53" />
-      <Map s="V_pls_brn" id="54" />
-      <Map s="Organism|Fat|Plasma|Volume" id="55" />
-      <Map s="V_pls_fat" id="56" />
-      <Map s="Organism|Gonads|Plasma|Volume" id="57" />
-      <Map s="V_pls_tes" id="58" />
-      <Map s="Organism|Heart|Plasma|Volume" id="59" />
-      <Map s="V_pls_hrt" id="60" />
-      <Map s="Organism|Kidney|Plasma|Volume" id="61" />
-      <Map s="V_pls_kid" id="62" />
-      <Map s="Organism|LargeIntestine|Plasma|Volume" id="63" />
-      <Map s="V_pls_lin" id="64" />
-      <Map s="Organism|Lung|Plasma|Volume" id="65" />
-      <Map s="V_pls_lng" id="66" />
-      <Map s="Organism|Muscle|Plasma|Volume" id="67" />
-      <Map s="V_pls_mus" id="68" />
-      <Map s="Organism|Pancreas|Plasma|Volume" id="69" />
-      <Map s="V_pls_pan" id="70" />
-      <Map s="Organism|PortalVein|Plasma|Volume" id="71" />
-      <Map s="V_pls_pve" id="72" />
-      <Map s="Organism|Skin|Plasma|Volume" id="73" />
-      <Map s="V_pls_skn" id="74" />
-      <Map s="Organism|SmallIntestine|Plasma|Volume" id="75" />
-      <Map s="V_pls_sin" id="76" />
-      <Map s="Organism|Spleen|Plasma|Volume" id="77" />
-      <Map s="V_pls_spl" id="78" />
-      <Map s="Organism|Stomach|Plasma|Volume" id="79" />
-      <Map s="V_pls_sto" id="80" />
-      <Map s="Organism|VenousBlood|Plasma|Volume" id="81" />
-      <Map s="V_pls_ven" id="82" />
-      <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Plasma|Volume" id="83" />
-      <Map s="V_pls_duo" id="84" />
-      <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Plasma|Volume" id="85" />
-      <Map s="V_pls_uje" id="86" />
-      <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Plasma|Volume" id="87" />
-      <Map s="V_pls_lje" id="88" />
-      <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Plasma|Volume" id="89" />
-      <Map s="V_pls_uil" id="90" />
-      <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Plasma|Volume" id="91" />
-      <Map s="V_pls_lil" id="92" />
-      <Map s="Organism|LargeIntestine|Mucosa|Caecum|Plasma|Volume" id="93" />
-      <Map s="V_pls_cae" id="94" />
-      <Map s="Organism|LargeIntestine|Mucosa|ColonAscendens|Plasma|Volume" id="95" />
-      <Map s="V_pls_colasc" id="96" />
-      <Map s="Organism|LargeIntestine|Mucosa|ColonTransversum|Plasma|Volume" id="97" />
-      <Map s="V_pls_coltrans" id="98" />
-      <Map s="Organism|LargeIntestine|Mucosa|ColonDescendens|Plasma|Volume" id="99" />
-      <Map s="V_pls_coldesc" id="100" />
-      <Map s="Organism|LargeIntestine|Mucosa|ColonSigmoid|Plasma|Volume" id="101" />
-      <Map s="V_pls_colsigm" id="102" />
-      <Map s="Organism|LargeIntestine|Mucosa|Rectum|Plasma|Volume" id="103" />
-      <Map s="V_pls_rect" id="104" />
-      <Map s="Organism|Liver|Periportal|Plasma|Volume" id="105" />
-      <Map s="V_pls_prp" id="106" />
-      <Map s="Organism|Liver|Pericentral|Plasma|Volume" id="107" />
-      <Map s="V_pls_prc" id="108" />
-      <Map s="Organism|Rate constant for endosomal uptake (global)" id="109" />
-      <Map s="K_uptake" id="110" />
-      <Map s="Inversed time" id="111" />
-      <Map s="Organism|Rate constant for recycling from endosomal space (global)" id="112" />
-      <Map s="K_rec" id="113" />
+      <Map s="Organism|Rate constant for endosomal uptake (global)" id="48" />
+      <Map s="K_uptake" id="49" />
+      <Map s="Inversed time" id="50" />
+      <Map s="Organism|Rate constant for recycling from endosomal space (global)" id="51" />
+      <Map s="K_rec" id="52" />
+      <Map s="Organism|ArterialBlood|Plasma|Volume" id="53" />
+      <Map s="V_pls_art" id="54" />
+      <Map s="Volume" id="55" />
+      <Map s="Organism|Bone|Plasma|Volume" id="56" />
+      <Map s="V_pls_bon" id="57" />
+      <Map s="Organism|Brain|Plasma|Volume" id="58" />
+      <Map s="V_pls_brn" id="59" />
+      <Map s="Organism|Fat|Plasma|Volume" id="60" />
+      <Map s="V_pls_fat" id="61" />
+      <Map s="Organism|Gonads|Plasma|Volume" id="62" />
+      <Map s="V_pls_tes" id="63" />
+      <Map s="Organism|Heart|Plasma|Volume" id="64" />
+      <Map s="V_pls_hrt" id="65" />
+      <Map s="Organism|Kidney|Plasma|Volume" id="66" />
+      <Map s="V_pls_kid" id="67" />
+      <Map s="Organism|LargeIntestine|Plasma|Volume" id="68" />
+      <Map s="V_pls_lin" id="69" />
+      <Map s="Organism|Lung|Plasma|Volume" id="70" />
+      <Map s="V_pls_lng" id="71" />
+      <Map s="Organism|Muscle|Plasma|Volume" id="72" />
+      <Map s="V_pls_mus" id="73" />
+      <Map s="Organism|Pancreas|Plasma|Volume" id="74" />
+      <Map s="V_pls_pan" id="75" />
+      <Map s="Organism|PortalVein|Plasma|Volume" id="76" />
+      <Map s="V_pls_pve" id="77" />
+      <Map s="Organism|Skin|Plasma|Volume" id="78" />
+      <Map s="V_pls_skn" id="79" />
+      <Map s="Organism|SmallIntestine|Plasma|Volume" id="80" />
+      <Map s="V_pls_sin" id="81" />
+      <Map s="Organism|Spleen|Plasma|Volume" id="82" />
+      <Map s="V_pls_spl" id="83" />
+      <Map s="Organism|Stomach|Plasma|Volume" id="84" />
+      <Map s="V_pls_sto" id="85" />
+      <Map s="Organism|VenousBlood|Plasma|Volume" id="86" />
+      <Map s="V_pls_ven" id="87" />
+      <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Plasma|Volume" id="88" />
+      <Map s="V_pls_duo" id="89" />
+      <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Plasma|Volume" id="90" />
+      <Map s="V_pls_uje" id="91" />
+      <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Plasma|Volume" id="92" />
+      <Map s="V_pls_lje" id="93" />
+      <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Plasma|Volume" id="94" />
+      <Map s="V_pls_uil" id="95" />
+      <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Plasma|Volume" id="96" />
+      <Map s="V_pls_lil" id="97" />
+      <Map s="Organism|LargeIntestine|Mucosa|Caecum|Plasma|Volume" id="98" />
+      <Map s="V_pls_cae" id="99" />
+      <Map s="Organism|LargeIntestine|Mucosa|ColonAscendens|Plasma|Volume" id="100" />
+      <Map s="V_pls_colasc" id="101" />
+      <Map s="Organism|LargeIntestine|Mucosa|ColonTransversum|Plasma|Volume" id="102" />
+      <Map s="V_pls_coltrans" id="103" />
+      <Map s="Organism|LargeIntestine|Mucosa|ColonDescendens|Plasma|Volume" id="104" />
+      <Map s="V_pls_coldesc" id="105" />
+      <Map s="Organism|LargeIntestine|Mucosa|ColonSigmoid|Plasma|Volume" id="106" />
+      <Map s="V_pls_colsigm" id="107" />
+      <Map s="Organism|LargeIntestine|Mucosa|Rectum|Plasma|Volume" id="108" />
+      <Map s="V_pls_rect" id="109" />
+      <Map s="Organism|Liver|Periportal|Plasma|Volume" id="110" />
+      <Map s="V_pls_prp" id="111" />
+      <Map s="Organism|Liver|Pericentral|Plasma|Volume" id="112" />
+      <Map s="V_pls_prc" id="113" />
       <Map s="Organism|Weight of blood organs" id="114" />
       <Map s="Weight_blood" id="115" />
       <Map s="Mass" id="116" />
@@ -22401,46 +22470,46 @@
       <Map s="Time" id="143" />
       <Map s="MOLECULE|Partition coefficient (blood cells/plasma)" id="144" />
       <Map s="K_rbc" id="145" />
-      <Map s="..|Gallbladder ejection half-time" id="146" />
-      <Map s="EHC_HalfTime" id="147" />
-      <Map s="..|Specific blood flow rate" id="148" />
-      <Map s="Qspec" id="149" />
-      <Map s="Flow per weight organ" id="150" />
-      <Map s="..|Weight (tissue)" id="151" />
-      <Map s="Weight" id="152" />
-      <Map s="..|Flow fraction via large pores" id="153" />
-      <Map s="alpha_l" id="154" />
-      <Map s="..|Fluid recirculation flow proportionality factor" id="155" />
-      <Map s="f_Jiso" id="156" />
-      <Map s="..|Lymph flow rate" id="157" />
-      <Map s="Q_lymph" id="158" />
-      <Map s="Flow" id="159" />
-      <Map s="..|Organ volume mouse" id="160" />
-      <Map s="V_mouse" id="161" />
-      <Map s="Organism|Scaling exponent for fluid recirculation flow rate" id="162" />
-      <Map s="exp_Jiso_scale" id="163" />
-      <Map s="..|Blood flow rate" id="164" />
-      <Map s="Q" id="165" />
-      <Map s="..|Lymph flow proportionality factor" id="166" />
-      <Map s="f_lymph" id="167" />
-      <Map s="Organism|Thickness (endothelium)" id="168" />
-      <Map s="d_endo" id="169" />
-      <Map s="Neighborhoods|Bone_pls_Bone_int|Surface area (plasma/interstitial)" id="170" />
-      <Map s="SA_pls_int" id="171" />
-      <Map s="Area" id="172" />
-      <Map s="..|Fraction interstitial" id="173" />
-      <Map s="f_int" id="174" />
-      <Map s="..|Fraction vascular" id="175" />
-      <Map s="V_org" id="176" />
-      <Map s="..|..|Fraction interstitial" id="177" />
-      <Map s="Organism|pH (interstitial)" id="178" />
-      <Map s="pH_int" id="179" />
-      <Map s="Neighborhoods|Bone_int_Bone_cell|MOLECULE|Partition coefficient (interstitial/water)" id="180" />
-      <Map s="K_water_int" id="181" />
-      <Map s="..|..|Fraction intracellular" id="182" />
-      <Map s="f_cell" id="183" />
-      <Map s="Neighborhoods|Bone_int_Bone_cell|MOLECULE|Partition coefficient (intracellular/water)" id="184" />
-      <Map s="K_water_cell" id="185" />
+      <Map s="..|Specific blood flow rate" id="146" />
+      <Map s="Qspec" id="147" />
+      <Map s="Flow per weight organ" id="148" />
+      <Map s="..|Weight (tissue)" id="149" />
+      <Map s="Weight" id="150" />
+      <Map s="..|Flow fraction via large pores" id="151" />
+      <Map s="alpha_l" id="152" />
+      <Map s="..|Fluid recirculation flow proportionality factor" id="153" />
+      <Map s="f_Jiso" id="154" />
+      <Map s="..|Lymph flow rate" id="155" />
+      <Map s="Q_lymph" id="156" />
+      <Map s="Flow" id="157" />
+      <Map s="..|Organ volume mouse" id="158" />
+      <Map s="V_mouse" id="159" />
+      <Map s="Organism|Scaling exponent for fluid recirculation flow rate" id="160" />
+      <Map s="exp_Jiso_scale" id="161" />
+      <Map s="..|Blood flow rate" id="162" />
+      <Map s="Q" id="163" />
+      <Map s="..|Lymph flow proportionality factor" id="164" />
+      <Map s="f_lymph" id="165" />
+      <Map s="Organism|Thickness (endothelium)" id="166" />
+      <Map s="d_endo" id="167" />
+      <Map s="Neighborhoods|Bone_pls_Bone_int|Surface area (plasma/interstitial)" id="168" />
+      <Map s="SA_pls_int" id="169" />
+      <Map s="Area" id="170" />
+      <Map s="..|Fraction interstitial" id="171" />
+      <Map s="f_int" id="172" />
+      <Map s="..|Fraction vascular" id="173" />
+      <Map s="V_org" id="174" />
+      <Map s="..|..|Fraction interstitial" id="175" />
+      <Map s="Organism|pH (interstitial)" id="176" />
+      <Map s="pH_int" id="177" />
+      <Map s="Neighborhoods|Bone_int_Bone_cell|MOLECULE|Partition coefficient (interstitial/water)" id="178" />
+      <Map s="K_water_int" id="179" />
+      <Map s="..|..|Fraction intracellular" id="180" />
+      <Map s="f_cell" id="181" />
+      <Map s="Neighborhoods|Bone_int_Bone_cell|MOLECULE|Partition coefficient (intracellular/water)" id="182" />
+      <Map s="K_water_cell" id="183" />
+      <Map s="..|Gallbladder ejection half-time" id="184" />
+      <Map s="EHC_HalfTime" id="185" />
       <Map s="Neighborhoods|Brain_pls_Brain_int|Surface area (plasma/interstitial)" id="186" />
       <Map s="Neighborhoods|Brain_int_Brain_cell|MOLECULE|Partition coefficient (interstitial/water)" id="187" />
       <Map s="Neighborhoods|Brain_int_Brain_cell|MOLECULE|Partition coefficient (intracellular/water)" id="188" />
@@ -22454,32 +22523,32 @@
       <Map s="Neighborhoods|Heart_int_Heart_cell|MOLECULE|Partition coefficient (interstitial/water)" id="196" />
       <Map s="Neighborhoods|Heart_int_Heart_cell|MOLECULE|Partition coefficient (intracellular/water)" id="197" />
       <Map s="Neighborhoods|Kidney_pls_Kidney_int|Surface area (plasma/interstitial)" id="198" />
-      <Map s="Organism|Age" id="199" />
-      <Map s="Organism|Kidney|Age of aging onset" id="200" />
-      <Map s="Age_onset" id="201" />
-      <Map s="Organism|Kidney|Aging half-time" id="202" />
-      <Map s="TA50" id="203" />
-      <Map s="Organism|Kidney|Hill coefficient for aging GFR" id="204" />
-      <Map s="Hill" id="205" />
-      <Map s="Organism|Kidney|Maximal decreasing rate factor" id="206" />
-      <Map s="Decrease_Factor" id="207" />
-      <Map s="Organism|Kidney|GFR (specific)" id="208" />
-      <Map s="GFRspec" id="209" />
-      <Map s="Organism|Kidney|Weight (tissue)" id="210" />
-      <Map s="Weight_Kidney" id="211" />
-      <Map s="Organism|Estimated gestational age" id="212" />
-      <Map s="PMA" id="213" />
-      <Map s="Organism|Kidney|fGFRpremat" id="214" />
-      <Map s="GFR_premat" id="215" />
-      <Map s="Organism|Kidney|GFRmat" id="216" />
-      <Map s="GFR_mat" id="217" />
-      <Map s="Organism|Kidney|Hill coefficient for GFR" id="218" />
-      <Map s="Organism|Kidney|Renal aging scaling factor" id="219" />
-      <Map s="Renal_aging_scaling_factor" id="220" />
-      <Map s="Organism|Kidney|TM50 for GFR" id="221" />
-      <Map s="TM50" id="222" />
-      <Map s="Organism|Kidney|Volume (standard kidney)" id="223" />
-      <Map s="V_kid_std" id="224" />
+      <Map s="Organism|Kidney|GFR (specific)" id="199" />
+      <Map s="GFRspec" id="200" />
+      <Map s="Organism|Kidney|Weight (tissue)" id="201" />
+      <Map s="Weight_Kidney" id="202" />
+      <Map s="Organism|Estimated gestational age" id="203" />
+      <Map s="PMA" id="204" />
+      <Map s="Organism|Kidney|GFRmat" id="205" />
+      <Map s="GFR_mat" id="206" />
+      <Map s="Organism|Kidney|Hill coefficient for GFR" id="207" />
+      <Map s="Hill" id="208" />
+      <Map s="Organism|Kidney|Renal aging scaling factor" id="209" />
+      <Map s="Renal_aging_scaling_factor" id="210" />
+      <Map s="Organism|Kidney|TM50 for GFR" id="211" />
+      <Map s="TM50" id="212" />
+      <Map s="Organism|Kidney|Volume (standard kidney)" id="213" />
+      <Map s="V_kid_std" id="214" />
+      <Map s="Organism|Kidney|fGFRpremat" id="215" />
+      <Map s="GFR_premat" id="216" />
+      <Map s="Organism|Age" id="217" />
+      <Map s="Organism|Kidney|Age of aging onset" id="218" />
+      <Map s="Age_onset" id="219" />
+      <Map s="Organism|Kidney|Aging half-time" id="220" />
+      <Map s="TA50" id="221" />
+      <Map s="Organism|Kidney|Hill coefficient for aging GFR" id="222" />
+      <Map s="Organism|Kidney|Maximal decreasing rate factor" id="223" />
+      <Map s="Decrease_Factor" id="224" />
       <Map s="Neighborhoods|Kidney_int_Kidney_cell|MOLECULE|Partition coefficient (interstitial/water)" id="225" />
       <Map s="Neighborhoods|Kidney_int_Kidney_cell|MOLECULE|Partition coefficient (intracellular/water)" id="226" />
       <Map s="..|Fraction of geometric volume filled with liquid" id="227" />
@@ -22508,36 +22577,36 @@
       <Map s="w" id="250" />
       <Map s="..|..|Duodenum|FillLevelFlag" id="251" />
       <Map s="FillLevelFlagNext" id="252" />
-      <Map s="..|Inverse rate of inflow of liquid into stomach" id="253" />
-      <Map s="StomachInflowTime" id="254" />
-      <Map s="..|Geometric surface area" id="255" />
-      <Map s="..|Thickness of gut wall" id="256" />
-      <Map s="d" id="257" />
-      <Map s="..|pH in fasted state" id="258" />
-      <Map s="pH_fasted" id="259" />
-      <Map s="..|pKa_pH_WS_lum_F1" id="260" />
-      <Map s="F1" id="261" />
-      <Map s="..|pKa_pH_WS_lum_F2" id="262" />
-      <Map s="F2" id="263" />
-      <Map s="..|pKa_pH_WS_lum_F3" id="264" />
-      <Map s="F3" id="265" />
-      <Map s="MOLECULE|Ontogeny factor GI" id="266" />
-      <Map s="MOLECULE|Compound type 0" id="267" />
-      <Map s="CT0" id="268" />
-      <Map s="MOLECULE|CT_NEUTRAL" id="269" />
-      <Map s="CT_NEUTRAL" id="270" />
-      <Map s="MOLECULE|pKa value 0" id="271" />
-      <Map s="pKa_0" id="272" />
-      <Map s="..|..|pH" id="273" />
-      <Map s="pH" id="274" />
-      <Map s="MOLECULE|Compound type 1" id="275" />
-      <Map s="CT1" id="276" />
-      <Map s="MOLECULE|pKa value 1" id="277" />
-      <Map s="pKa_1" id="278" />
-      <Map s="MOLECULE|Compound type 2" id="279" />
-      <Map s="CT2" id="280" />
-      <Map s="MOLECULE|pKa value 2" id="281" />
-      <Map s="pKa_2" id="282" />
+      <Map s="..|pH in fasted state" id="253" />
+      <Map s="pH_fasted" id="254" />
+      <Map s="..|Inverse rate of inflow of liquid into stomach" id="255" />
+      <Map s="StomachInflowTime" id="256" />
+      <Map s="..|Geometric surface area" id="257" />
+      <Map s="..|Thickness of gut wall" id="258" />
+      <Map s="d" id="259" />
+      <Map s="MOLECULE|Ontogeny factor GI" id="260" />
+      <Map s="MOLECULE|CT_NEUTRAL" id="261" />
+      <Map s="CT_NEUTRAL" id="262" />
+      <Map s="MOLECULE|Compound type 0" id="263" />
+      <Map s="CT0" id="264" />
+      <Map s="MOLECULE|pKa value 0" id="265" />
+      <Map s="pKa_0" id="266" />
+      <Map s="..|..|pH" id="267" />
+      <Map s="pH" id="268" />
+      <Map s="MOLECULE|Compound type 1" id="269" />
+      <Map s="CT1" id="270" />
+      <Map s="MOLECULE|pKa value 1" id="271" />
+      <Map s="pKa_1" id="272" />
+      <Map s="MOLECULE|Compound type 2" id="273" />
+      <Map s="CT2" id="274" />
+      <Map s="MOLECULE|pKa value 2" id="275" />
+      <Map s="pKa_2" id="276" />
+      <Map s="..|pKa_pH_WS_lum_F1" id="277" />
+      <Map s="F1" id="278" />
+      <Map s="..|pKa_pH_WS_lum_F2" id="279" />
+      <Map s="F2" id="280" />
+      <Map s="..|pKa_pH_WS_lum_F3" id="281" />
+      <Map s="F3" id="282" />
       <Map s="..|Solubility table" id="283" />
       <Map s="SolubilityTable" id="284" />
       <Map s="Concentration (mass)" id="285" />
@@ -22569,571 +22638,557 @@
       <Map s="MOLECULE|Solubility gain per charge" id="311" />
       <Map s="base" id="312" />
       <Map s="MOLECULE|t1/2 (intestine)" id="313" />
-      <Map s="..|Intestinal transit rate" id="314" />
-      <Map s="LuminalVelocity" id="315" />
-      <Map s="Organism|SmallIntestine|Small intestinal transit time factor" id="316" />
-      <Map s="SITT_fact" id="317" />
-      <Map s="..|..|..|Height" id="318" />
-      <Map s="..|L_p0" id="319" />
-      <Map s="L_p0" id="320" />
-      <Map s="..|L_p1" id="321" />
-      <Map s="L_p1" id="322" />
-      <Map s="..|Absorption of liquid" id="323" />
-      <Map s="Outflow" id="324" />
-      <Map s="LT_duo" id="325" />
-      <Map s="..|..|Stomach|Liquid transfer rate" id="326" />
-      <Map s="..|..|UpperJejunum|FillLevelFlag" id="327" />
-      <Map s="..|r1_p0" id="328" />
-      <Map s="r1_p0" id="329" />
-      <Map s="..|r1_p1" id="330" />
-      <Map s="r1_p1" id="331" />
-      <Map s="..|Thickness_p1" id="332" />
-      <Map s="Thickness_p1" id="333" />
-      <Map s="..|Thickness_p2" id="334" />
-      <Map s="Thickness_p2" id="335" />
-      <Map s="..|Thickness_p3" id="336" />
-      <Map s="Thickness_p3" id="337" />
-      <Map s="Inversed length" id="338" />
-      <Map s="Organism|SmallIntestine|Volume" id="339" />
-      <Map s="V_Intestine" id="340" />
-      <Map s="alpha" id="341" />
-      <Map s="k" id="342" />
-      <Map s="inflow" id="343" />
-      <Map s="..|..|Stomach|Fractional steady state fill level" id="344" />
-      <Map s="alpha_p" id="345" />
-      <Map s="..|..|Stomach|Intestinal transit rate (absolute)" id="346" />
-      <Map s="k_p" id="347" />
-      <Map s="..|..|Stomach|Volume" id="348" />
-      <Map s="V_p" id="349" />
-      <Map s="..|r2_p0" id="350" />
-      <Map s="r2_p0" id="351" />
-      <Map s="..|r2_p1" id="352" />
-      <Map s="r2_p1" id="353" />
-      <Map s="..|Effective surface area enhancement factor" id="354" />
-      <Map s="AeffFactor" id="355" />
-      <Map s="Ageom" id="356" />
-      <Map s="Organism|Lumen|Effective surface area variability factor" id="357" />
-      <Map s="AeffVariabilityFactor" id="358" />
-      <Map s="Neighborhoods|Lumen_duo_Duodenum_pls|MOLECULE|Sum of active process rates" id="359" />
-      <Map s="ActiveRates_para" id="360" />
-      <Map s="Amount per time" id="361" />
-      <Map s="Neighborhoods|Lumen_duo_Duodenum_cell|MOLECULE|Sum of active process rates" id="362" />
-      <Map s="ActiveRates_trans" id="363" />
-      <Map s="Neighborhoods|Lumen_duo_Duodenum_pls|MOLECULE|Sum of passive process rates" id="364" />
-      <Map s="PassiveRates_para" id="365" />
-      <Map s="Neighborhoods|Lumen_duo_Duodenum_cell|MOLECULE|Sum of passive process rates" id="366" />
-      <Map s="PassiveRates_trans" id="367" />
-      <Map s="LT_uje" id="368" />
-      <Map s="..|..|Duodenum|Liquid transfer rate" id="369" />
-      <Map s="..|..|LowerJejunum|FillLevelFlag" id="370" />
-      <Map s="..|..|Duodenum|Fractional steady state fill level" id="371" />
-      <Map s="..|..|Duodenum|Intestinal transit rate (absolute)" id="372" />
-      <Map s="..|..|Duodenum|Volume" id="373" />
-      <Map s="Neighborhoods|Lumen_uje_UpperJejunum_pls|MOLECULE|Sum of active process rates" id="374" />
-      <Map s="Neighborhoods|Lumen_uje_UpperJejunum_cell|MOLECULE|Sum of active process rates" id="375" />
-      <Map s="Neighborhoods|Lumen_uje_UpperJejunum_pls|MOLECULE|Sum of passive process rates" id="376" />
-      <Map s="Neighborhoods|Lumen_uje_UpperJejunum_cell|MOLECULE|Sum of passive process rates" id="377" />
-      <Map s="..|..|UpperIleum|FillLevelFlag" id="378" />
-      <Map s="LT_lje" id="379" />
-      <Map s="..|..|UpperJejunum|Liquid transfer rate" id="380" />
-      <Map s="..|..|UpperJejunum|Fractional steady state fill level" id="381" />
-      <Map s="..|..|UpperJejunum|Intestinal transit rate (absolute)" id="382" />
-      <Map s="..|..|UpperJejunum|Volume" id="383" />
-      <Map s="Neighborhoods|Lumen_lje_LowerJejunum_pls|MOLECULE|Sum of active process rates" id="384" />
-      <Map s="Neighborhoods|Lumen_lje_LowerJejunum_cell|MOLECULE|Sum of active process rates" id="385" />
-      <Map s="Neighborhoods|Lumen_lje_LowerJejunum_pls|MOLECULE|Sum of passive process rates" id="386" />
-      <Map s="Neighborhoods|Lumen_lje_LowerJejunum_cell|MOLECULE|Sum of passive process rates" id="387" />
-      <Map s="..|..|LowerJejunum|Fractional steady state fill level" id="388" />
-      <Map s="..|..|LowerJejunum|Intestinal transit rate (absolute)" id="389" />
-      <Map s="..|..|LowerJejunum|Volume" id="390" />
-      <Map s="LT_uil" id="391" />
-      <Map s="..|..|LowerJejunum|Liquid transfer rate" id="392" />
-      <Map s="..|..|LowerIleum|FillLevelFlag" id="393" />
-      <Map s="Neighborhoods|Lumen_uil_UpperIleum_pls|MOLECULE|Sum of active process rates" id="394" />
-      <Map s="Neighborhoods|Lumen_uil_UpperIleum_cell|MOLECULE|Sum of active process rates" id="395" />
-      <Map s="Neighborhoods|Lumen_uil_UpperIleum_pls|MOLECULE|Sum of passive process rates" id="396" />
-      <Map s="Neighborhoods|Lumen_uil_UpperIleum_cell|MOLECULE|Sum of passive process rates" id="397" />
-      <Map s="..|..|UpperIleum|Fractional steady state fill level" id="398" />
-      <Map s="..|..|UpperIleum|Intestinal transit rate (absolute)" id="399" />
-      <Map s="..|..|UpperIleum|Volume" id="400" />
-      <Map s="LT_lil" id="401" />
-      <Map s="..|..|UpperIleum|Liquid transfer rate" id="402" />
-      <Map s="..|..|Caecum|FillLevelFlag" id="403" />
-      <Map s="Neighborhoods|Lumen_lil_LowerIleum_pls|MOLECULE|Sum of active process rates" id="404" />
-      <Map s="Neighborhoods|Lumen_lil_LowerIleum_cell|MOLECULE|Sum of active process rates" id="405" />
-      <Map s="Neighborhoods|Lumen_lil_LowerIleum_pls|MOLECULE|Sum of passive process rates" id="406" />
-      <Map s="Neighborhoods|Lumen_lil_LowerIleum_cell|MOLECULE|Sum of passive process rates" id="407" />
-      <Map s="Organism|LargeIntestine|Volume" id="408" />
-      <Map s="Organism|LargeIntestine|Large intestinal transit time factor" id="409" />
-      <Map s="LITT_fact" id="410" />
-      <Map s="..|..|LowerIleum|Fractional steady state fill level" id="411" />
-      <Map s="..|..|LowerIleum|Intestinal transit rate (absolute)" id="412" />
-      <Map s="..|..|LowerIleum|Volume" id="413" />
-      <Map s="LT_cae" id="414" />
-      <Map s="..|..|LowerIleum|Liquid transfer rate" id="415" />
-      <Map s="..|..|ColonAscendens|FillLevelFlag" id="416" />
-      <Map s="Neighborhoods|Lumen_cae_Caecum_pls|MOLECULE|Sum of active process rates" id="417" />
-      <Map s="Neighborhoods|Lumen_cae_Caecum_cell|MOLECULE|Sum of active process rates" id="418" />
-      <Map s="Neighborhoods|Lumen_cae_Caecum_pls|MOLECULE|Sum of passive process rates" id="419" />
-      <Map s="Neighborhoods|Lumen_cae_Caecum_cell|MOLECULE|Sum of passive process rates" id="420" />
-      <Map s="LT_colasc" id="421" />
-      <Map s="..|..|Caecum|Liquid transfer rate" id="422" />
-      <Map s="..|..|Caecum|Fractional steady state fill level" id="423" />
-      <Map s="..|..|Caecum|Intestinal transit rate (absolute)" id="424" />
-      <Map s="..|..|Caecum|Volume" id="425" />
-      <Map s="..|..|ColonTransversum|FillLevelFlag" id="426" />
-      <Map s="Neighborhoods|Lumen_colasc_ColonAscendens_pls|MOLECULE|Sum of active process rates" id="427" />
-      <Map s="Neighborhoods|Lumen_colasc_ColonAscendens_cell|MOLECULE|Sum of active process rates" id="428" />
-      <Map s="Neighborhoods|Lumen_colasc_ColonAscendens_pls|MOLECULE|Sum of passive process rates" id="429" />
-      <Map s="Neighborhoods|Lumen_colasc_ColonAscendens_cell|MOLECULE|Sum of passive process rates" id="430" />
-      <Map s="..|..|ColonDescendens|FillLevelFlag" id="431" />
-      <Map s="LT_coltrans" id="432" />
-      <Map s="..|..|ColonAscendens|Liquid transfer rate" id="433" />
-      <Map s="..|..|ColonAscendens|Fractional steady state fill level" id="434" />
-      <Map s="..|..|ColonAscendens|Intestinal transit rate (absolute)" id="435" />
-      <Map s="..|..|ColonAscendens|Volume" id="436" />
-      <Map s="Neighborhoods|Lumen_coltrans_ColonTransversum_pls|MOLECULE|Sum of active process rates" id="437" />
-      <Map s="Neighborhoods|Lumen_coltrans_ColonTransversum_cell|MOLECULE|Sum of active process rates" id="438" />
-      <Map s="Neighborhoods|Lumen_coltrans_ColonTransversum_pls|MOLECULE|Sum of passive process rates" id="439" />
-      <Map s="Neighborhoods|Lumen_coltrans_ColonTransversum_cell|MOLECULE|Sum of passive process rates" id="440" />
-      <Map s="..|..|ColonTransversum|Fractional steady state fill level" id="441" />
-      <Map s="..|..|ColonTransversum|Intestinal transit rate (absolute)" id="442" />
-      <Map s="..|..|ColonTransversum|Volume" id="443" />
-      <Map s="LT_coldesc" id="444" />
-      <Map s="..|..|ColonTransversum|Liquid transfer rate" id="445" />
-      <Map s="..|..|ColonSigmoid|FillLevelFlag" id="446" />
-      <Map s="Neighborhoods|Lumen_coldesc_ColonDescendens_pls|MOLECULE|Sum of active process rates" id="447" />
-      <Map s="Neighborhoods|Lumen_coldesc_ColonDescendens_cell|MOLECULE|Sum of active process rates" id="448" />
-      <Map s="Neighborhoods|Lumen_coldesc_ColonDescendens_pls|MOLECULE|Sum of passive process rates" id="449" />
-      <Map s="Neighborhoods|Lumen_coldesc_ColonDescendens_cell|MOLECULE|Sum of passive process rates" id="450" />
-      <Map s="LT_colsigm" id="451" />
-      <Map s="..|..|ColonDescendens|Liquid transfer rate" id="452" />
-      <Map s="..|..|Rectum|FillLevelFlag" id="453" />
-      <Map s="..|..|ColonDescendens|Fractional steady state fill level" id="454" />
-      <Map s="..|..|ColonDescendens|Intestinal transit rate (absolute)" id="455" />
-      <Map s="..|..|ColonDescendens|Volume" id="456" />
-      <Map s="Neighborhoods|Lumen_colsigm_ColonSigmoid_pls|MOLECULE|Sum of active process rates" id="457" />
-      <Map s="Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|MOLECULE|Sum of active process rates" id="458" />
-      <Map s="Neighborhoods|Lumen_colsigm_ColonSigmoid_pls|MOLECULE|Sum of passive process rates" id="459" />
-      <Map s="Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|MOLECULE|Sum of passive process rates" id="460" />
-      <Map s="..|..|ColonSigmoid|Fractional steady state fill level" id="461" />
-      <Map s="..|..|ColonSigmoid|Intestinal transit rate (absolute)" id="462" />
-      <Map s="..|..|ColonSigmoid|Volume" id="463" />
-      <Map s="LT_rect" id="464" />
-      <Map s="..|..|ColonSigmoid|Liquid transfer rate" id="465" />
-      <Map s="Neighborhoods|Lumen_rect_Rectum_pls|MOLECULE|Sum of active process rates" id="466" />
-      <Map s="Neighborhoods|Lumen_rect_Rectum_cell|MOLECULE|Sum of active process rates" id="467" />
-      <Map s="Neighborhoods|Lumen_rect_Rectum_pls|MOLECULE|Sum of passive process rates" id="468" />
-      <Map s="Neighborhoods|Lumen_rect_Rectum_cell|MOLECULE|Sum of passive process rates" id="469" />
-      <Map s="..|..|Rectum|Liquid transfer rate" id="470" />
-      <Map s="LT_rec" id="471" />
-      <Map s="Neighborhoods|Stomach_pls_Stomach_int|Surface area (plasma/interstitial)" id="472" />
-      <Map s="Neighborhoods|Stomach_int_Stomach_cell|MOLECULE|Partition coefficient (interstitial/water)" id="473" />
-      <Map s="Neighborhoods|Stomach_int_Stomach_cell|MOLECULE|Partition coefficient (intracellular/water)" id="474" />
-      <Map s="..|Small intestinal transit time" id="475" />
-      <Map s="SITT" id="476" />
-      <Map s="..|Small intestinal transit time factor intercept" id="477" />
-      <Map s="P2" id="478" />
-      <Map s="..|Small intestinal transit time factor slope" id="479" />
-      <Map s="P1" id="480" />
-      <Map s="..|Fluid recirculation flow rate (incl. mucosa)" id="481" />
-      <Map s="J_iso_incl_Mucosa" id="482" />
-      <Map s="..|Mucosa|Duodenum|Fluid recirculation flow rate" id="483" />
-      <Map s="J_iso_duo" id="484" />
-      <Map s="..|Mucosa|LowerIleum|Fluid recirculation flow rate" id="485" />
-      <Map s="J_iso_lil" id="486" />
-      <Map s="..|Mucosa|LowerJejunum|Fluid recirculation flow rate" id="487" />
-      <Map s="J_iso_lje" id="488" />
-      <Map s="..|Mucosa|UpperIleum|Fluid recirculation flow rate" id="489" />
-      <Map s="J_iso_uil" id="490" />
-      <Map s="..|Mucosa|UpperJejunum|Fluid recirculation flow rate" id="491" />
-      <Map s="J_iso_uje" id="492" />
-      <Map s="Neighborhoods|SmallIntestine_pls_SmallIntestine_int|Surface area (plasma/interstitial)" id="493" />
-      <Map s="..|Lymph flow rate (incl. mucosa)" id="494" />
-      <Map s="Q_lymph_incl_Mucosa" id="495" />
-      <Map s="..|Mucosa|Duodenum|Lymph flow rate" id="496" />
-      <Map s="Q_lymph_duo" id="497" />
-      <Map s="..|Mucosa|LowerIleum|Lymph flow rate" id="498" />
-      <Map s="Q_lymph_lil" id="499" />
-      <Map s="..|Mucosa|LowerJejunum|Lymph flow rate" id="500" />
-      <Map s="Q_lymph_lje" id="501" />
-      <Map s="..|Mucosa|UpperIleum|Lymph flow rate" id="502" />
-      <Map s="Q_lymph_uil" id="503" />
-      <Map s="..|Mucosa|UpperJejunum|Lymph flow rate" id="504" />
-      <Map s="Q_lymph_uje" id="505" />
-      <Map s="..|Mucosa|Duodenum|Volume" id="506" />
-      <Map s="V_duo" id="507" />
-      <Map s="..|Mucosa|LowerIleum|Volume" id="508" />
-      <Map s="V_lil" id="509" />
-      <Map s="..|Mucosa|LowerJejunum|Volume" id="510" />
-      <Map s="V_lje" id="511" />
-      <Map s="..|Mucosa|UpperIleum|Volume" id="512" />
-      <Map s="V_uil" id="513" />
-      <Map s="..|Mucosa|UpperJejunum|Volume" id="514" />
-      <Map s="V_uje" id="515" />
-      <Map s="..|..|Volume (mucosa)" id="516" />
-      <Map s="V_Mucosa" id="517" />
-      <Map s="Neighborhoods|SmallIntestine_int_SmallIntestine_cell|MOLECULE|Partition coefficient (interstitial/water)" id="518" />
-      <Map s="Neighborhoods|SmallIntestine_int_SmallIntestine_cell|MOLECULE|Partition coefficient (intracellular/water)" id="519" />
-      <Map s="..|Fraction mucosa" id="520" />
-      <Map s="fractionMucosa" id="521" />
-      <Map s="..|..|..|..|Lumen|Duodenum|Volume (gut wall)" id="522" />
-      <Map s="V_GutWall" id="523" />
-      <Map s="..|..|..|Lymph flow rate (incl. mucosa)" id="524" />
-      <Map s="Q_lymph_intestine" id="525" />
-      <Map s="..|..|..|Volume" id="526" />
-      <Map s="V_intestine" id="527" />
-      <Map s="V_seg" id="528" />
-      <Map s="Neighborhoods|Duodenum_pls_Duodenum_int|Surface area (plasma/interstitial)" id="529" />
-      <Map s="..|..|..|Fluid recirculation flow rate (incl. mucosa)" id="530" />
-      <Map s="J_iso_intestine" id="531" />
-      <Map s="..|..|..|Blood flow rate" id="532" />
-      <Map s="..|Fraction of regional blood flow rate" id="533" />
-      <Map s="regionalFractQ" id="534" />
-      <Map s="..|..|..|Mucosa blood flow fraction" id="535" />
-      <Map s="fractQ" id="536" />
-      <Map s="Neighborhoods|Duodenum_int_Duodenum_cell|MOLECULE|Partition coefficient (interstitial/water)" id="537" />
-      <Map s="Neighborhoods|Duodenum_int_Duodenum_cell|MOLECULE|Partition coefficient (intracellular/water)" id="538" />
-      <Map s="..|..|..|..|Lumen|UpperJejunum|Volume (gut wall)" id="539" />
-      <Map s="Neighborhoods|UpperJejunum_pls_UpperJejunum_int|Surface area (plasma/interstitial)" id="540" />
-      <Map s="Neighborhoods|UpperJejunum_int_UpperJejunum_cell|MOLECULE|Partition coefficient (interstitial/water)" id="541" />
-      <Map s="Neighborhoods|UpperJejunum_int_UpperJejunum_cell|MOLECULE|Partition coefficient (intracellular/water)" id="542" />
-      <Map s="..|..|..|..|Lumen|LowerJejunum|Volume (gut wall)" id="543" />
-      <Map s="Neighborhoods|LowerJejunum_pls_LowerJejunum_int|Surface area (plasma/interstitial)" id="544" />
-      <Map s="Neighborhoods|LowerJejunum_int_LowerJejunum_cell|MOLECULE|Partition coefficient (interstitial/water)" id="545" />
-      <Map s="Neighborhoods|LowerJejunum_int_LowerJejunum_cell|MOLECULE|Partition coefficient (intracellular/water)" id="546" />
-      <Map s="..|..|..|..|Lumen|UpperIleum|Volume (gut wall)" id="547" />
-      <Map s="Neighborhoods|UpperIleum_pls_UpperIleum_int|Surface area (plasma/interstitial)" id="548" />
-      <Map s="Neighborhoods|UpperIleum_int_UpperIleum_cell|MOLECULE|Partition coefficient (interstitial/water)" id="549" />
-      <Map s="Neighborhoods|UpperIleum_int_UpperIleum_cell|MOLECULE|Partition coefficient (intracellular/water)" id="550" />
-      <Map s="..|..|..|..|Lumen|LowerIleum|Volume (gut wall)" id="551" />
-      <Map s="Neighborhoods|LowerIleum_pls_LowerIleum_int|Surface area (plasma/interstitial)" id="552" />
-      <Map s="Neighborhoods|LowerIleum_int_LowerIleum_cell|MOLECULE|Partition coefficient (interstitial/water)" id="553" />
-      <Map s="Neighborhoods|LowerIleum_int_LowerIleum_cell|MOLECULE|Partition coefficient (intracellular/water)" id="554" />
-      <Map s="..|Mucosa|Caecum|Volume" id="555" />
-      <Map s="V_cae" id="556" />
-      <Map s="..|Mucosa|ColonAscendens|Volume" id="557" />
-      <Map s="V_ca" id="558" />
-      <Map s="..|Mucosa|ColonDescendens|Volume" id="559" />
-      <Map s="V_cd" id="560" />
-      <Map s="..|Mucosa|ColonSigmoid|Volume" id="561" />
-      <Map s="V_cs" id="562" />
-      <Map s="..|Mucosa|ColonTransversum|Volume" id="563" />
-      <Map s="V_ct" id="564" />
-      <Map s="..|Mucosa|Rectum|Volume" id="565" />
-      <Map s="V_rec" id="566" />
-      <Map s="..|Large intestinal transit time" id="567" />
-      <Map s="LITT" id="568" />
-      <Map s="..|Large intestinal transit time factor intercept" id="569" />
-      <Map s="..|Large intestinal transit time factor slope" id="570" />
-      <Map s="Neighborhoods|LargeIntestine_pls_LargeIntestine_int|Surface area (plasma/interstitial)" id="571" />
-      <Map s="..|Mucosa|Caecum|Lymph flow rate" id="572" />
-      <Map s="Q_lymph_cae" id="573" />
-      <Map s="..|Mucosa|ColonAscendens|Lymph flow rate" id="574" />
-      <Map s="Q_lymph_colasc" id="575" />
-      <Map s="..|Mucosa|ColonDescendens|Lymph flow rate" id="576" />
-      <Map s="Q_lymph_coldesc" id="577" />
-      <Map s="..|Mucosa|ColonSigmoid|Lymph flow rate" id="578" />
-      <Map s="Q_lymph_colsigm" id="579" />
-      <Map s="..|Mucosa|ColonTransversum|Lymph flow rate" id="580" />
-      <Map s="Q_lymph_coltrans" id="581" />
-      <Map s="..|Mucosa|Rectum|Lymph flow rate" id="582" />
-      <Map s="Q_lymph_rect" id="583" />
-      <Map s="..|Mucosa|Caecum|Fluid recirculation flow rate" id="584" />
-      <Map s="J_iso_cae" id="585" />
-      <Map s="..|Mucosa|ColonAscendens|Fluid recirculation flow rate" id="586" />
-      <Map s="J_iso_colasc" id="587" />
-      <Map s="..|Mucosa|ColonDescendens|Fluid recirculation flow rate" id="588" />
-      <Map s="J_iso_coldesc" id="589" />
-      <Map s="..|Mucosa|ColonSigmoid|Fluid recirculation flow rate" id="590" />
-      <Map s="J_iso_colsigm" id="591" />
-      <Map s="..|Mucosa|ColonTransversum|Fluid recirculation flow rate" id="592" />
-      <Map s="J_iso_coltrans" id="593" />
-      <Map s="..|Mucosa|Rectum|Fluid recirculation flow rate" id="594" />
-      <Map s="J_iso_rect" id="595" />
-      <Map s="Neighborhoods|LargeIntestine_int_LargeIntestine_cell|MOLECULE|Partition coefficient (interstitial/water)" id="596" />
-      <Map s="Neighborhoods|LargeIntestine_int_LargeIntestine_cell|MOLECULE|Partition coefficient (intracellular/water)" id="597" />
-      <Map s="..|..|..|..|Lumen|Caecum|Volume (gut wall)" id="598" />
-      <Map s="Neighborhoods|Caecum_pls_Caecum_int|Surface area (plasma/interstitial)" id="599" />
-      <Map s="Neighborhoods|Caecum_int_Caecum_cell|MOLECULE|Partition coefficient (interstitial/water)" id="600" />
-      <Map s="Neighborhoods|Caecum_int_Caecum_cell|MOLECULE|Partition coefficient (intracellular/water)" id="601" />
-      <Map s="..|..|..|..|Lumen|ColonAscendens|Volume (gut wall)" id="602" />
-      <Map s="Neighborhoods|ColonAscendens_pls_ColonAscendens_int|Surface area (plasma/interstitial)" id="603" />
-      <Map s="Neighborhoods|ColonAscendens_int_ColonAscendens_cell|MOLECULE|Partition coefficient (interstitial/water)" id="604" />
-      <Map s="Neighborhoods|ColonAscendens_int_ColonAscendens_cell|MOLECULE|Partition coefficient (intracellular/water)" id="605" />
-      <Map s="..|..|..|..|Lumen|ColonTransversum|Volume (gut wall)" id="606" />
-      <Map s="Neighborhoods|ColonTransversum_pls_ColonTransversum_int|Surface area (plasma/interstitial)" id="607" />
-      <Map s="Neighborhoods|ColonTransversum_int_ColonTransversum_cell|MOLECULE|Partition coefficient (interstitial/water)" id="608" />
-      <Map s="Neighborhoods|ColonTransversum_int_ColonTransversum_cell|MOLECULE|Partition coefficient (intracellular/water)" id="609" />
-      <Map s="..|..|..|..|Lumen|ColonDescendens|Volume (gut wall)" id="610" />
-      <Map s="Neighborhoods|ColonDescendens_pls_ColonDescendens_int|Surface area (plasma/interstitial)" id="611" />
-      <Map s="Neighborhoods|ColonDescendens_int_ColonDescendens_cell|MOLECULE|Partition coefficient (interstitial/water)" id="612" />
-      <Map s="Neighborhoods|ColonDescendens_int_ColonDescendens_cell|MOLECULE|Partition coefficient (intracellular/water)" id="613" />
-      <Map s="..|..|..|..|Lumen|ColonSigmoid|Volume (gut wall)" id="614" />
-      <Map s="Neighborhoods|ColonSigmoid_pls_ColonSigmoid_int|Surface area (plasma/interstitial)" id="615" />
-      <Map s="Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|MOLECULE|Partition coefficient (interstitial/water)" id="616" />
-      <Map s="Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|MOLECULE|Partition coefficient (intracellular/water)" id="617" />
-      <Map s="..|..|..|..|Lumen|Rectum|Volume (gut wall)" id="618" />
-      <Map s="Neighborhoods|Rectum_pls_Rectum_int|Surface area (plasma/interstitial)" id="619" />
-      <Map s="Neighborhoods|Rectum_int_Rectum_cell|MOLECULE|Partition coefficient (interstitial/water)" id="620" />
-      <Map s="Neighborhoods|Rectum_int_Rectum_cell|MOLECULE|Partition coefficient (intracellular/water)" id="621" />
-      <Map s="Neighborhoods|Liver_pls_Liver_int|Surface area (plasma/interstitial)" id="622" />
-      <Map s="..|..|Fraction of blood for sampling" id="623" />
-      <Map s="Liver_Parameter" id="624" />
-      <Map s="..|..|Density (tissue)" id="625" />
-      <Map s="..|..|Allometric scale factor" id="626" />
-      <Map s="Organism|Liver|Fraction of periportal zone" id="627" />
-      <Map s="f_periportal" id="628" />
-      <Map s="Organism|Liver|Is liver zonated" id="629" />
-      <Map s="IsLiverZonated" id="630" />
-      <Map s="Organism|Liver|Volume" id="631" />
-      <Map s="V_liv" id="632" />
-      <Map s="..|..|Radius (small pores)" id="633" />
-      <Map s="..|..|Radius (large pores)" id="634" />
-      <Map s="Neighborhoods|Periportal_pls_Periportal_int|Surface area (plasma/interstitial)" id="635" />
-      <Map s="..|..|Lymph flow rate" id="636" />
-      <Map s="..|..|Hydraulic conductivity" id="637" />
-      <Map s="Hydraulic conductivity" id="638" />
-      <Map s="..|..|Fluid recirculation flow rate" id="639" />
-      <Map s="J_iso" id="640" />
-      <Map s="..|..|Flow fraction via large pores" id="641" />
-      <Map s="..|..|Vf (neutral lipid)-PT" id="642" />
-      <Map s="..|..|Vf (lipid)" id="643" />
-      <Map s="..|..|Vf (phospholipid)-PT" id="644" />
-      <Map s="..|..|Vf (protein)" id="645" />
-      <Map s="..|..|Albumin ratio (tissue/plasma)" id="646" />
-      <Map s="..|..|Lipoprotein ratio (tissue/plasma)" id="647" />
-      <Map s="..|..|Vf (water)-PT" id="648" />
-      <Map s="..|..|Number of cells/g tissue" id="649" />
-      <Map s="Count per mass" id="650" />
-      <Map s="..|..|Microsomal protein mass/g tissue" id="651" />
-      <Map s="Mass per tissue" id="652" />
-      <Map s="..|..|Albumin ratio (tissue/plasma)-PT" id="653" />
-      <Map s="..|..|Vf (water)" id="654" />
-      <Map s="..|..|Vf (neutral lipid)-RR" id="655" />
-      <Map s="..|..|Vf (neutral lipid)-WS" id="656" />
-      <Map s="..|..|Vf (neutral phospholipid)-RR" id="657" />
-      <Map s="..|..|Vf (neutral phospholipid, plasma)-WS" id="658" />
-      <Map s="..|..|Vf (protein)-WS" id="659" />
-      <Map s="..|..|Vf (extracellular water)-RR" id="660" />
-      <Map s="..|..|Vf (water)-WS" id="661" />
-      <Map s="..|..|Vf (intracellular water)-RR" id="662" />
-      <Map s="..|..|Acidic phospholipids [mg/g] - RR" id="663" />
-      <Map s="..|..|Vf (acidic phospholipids)-WS" id="664" />
-      <Map s="..|..|Specific blood flow rate" id="665" />
-      <Map s="..|..|Blood flow rate" id="666" />
-      <Map s="Neighborhoods|Periportal_int_Periportal_cell|MOLECULE|Partition coefficient (interstitial/water)" id="667" />
-      <Map s="Organism|Liver|Intracellular|pH" id="668" />
-      <Map s="pH_cell_Liver" id="669" />
-      <Map s="Neighborhoods|Periportal_int_Periportal_cell|MOLECULE|Partition coefficient (intracellular/water)" id="670" />
-      <Map s="Neighborhoods|Pericentral_pls_Pericentral_int|Surface area (plasma/interstitial)" id="671" />
-      <Map s="Neighborhoods|Lung_pls_Lung_int|Surface area (plasma/interstitial)" id="672" />
-      <Map s="Organism|Bone|Blood flow rate" id="673" />
-      <Map s="Q_bon" id="674" />
-      <Map s="Organism|Brain|Blood flow rate" id="675" />
-      <Map s="Q_brn" id="676" />
-      <Map s="Organism|Fat|Blood flow rate" id="677" />
-      <Map s="Q_fat" id="678" />
-      <Map s="Organism|Gonads|Blood flow rate" id="679" />
-      <Map s="Q_tes" id="680" />
-      <Map s="Organism|Heart|Blood flow rate" id="681" />
-      <Map s="Q_hrt" id="682" />
-      <Map s="Organism|Kidney|Blood flow rate" id="683" />
-      <Map s="Q_kid" id="684" />
-      <Map s="Organism|LargeIntestine|Blood flow rate" id="685" />
-      <Map s="Q_lin" id="686" />
-      <Map s="Organism|Liver|Blood flow rate" id="687" />
-      <Map s="Q_liv" id="688" />
-      <Map s="Organism|Muscle|Blood flow rate" id="689" />
-      <Map s="Q_mus" id="690" />
-      <Map s="Organism|Pancreas|Blood flow rate" id="691" />
-      <Map s="Q_pan" id="692" />
-      <Map s="Organism|Skin|Blood flow rate" id="693" />
-      <Map s="Q_skn" id="694" />
-      <Map s="Organism|SmallIntestine|Blood flow rate" id="695" />
-      <Map s="Q_sin" id="696" />
-      <Map s="Organism|Spleen|Blood flow rate" id="697" />
-      <Map s="Q_spl" id="698" />
-      <Map s="Organism|Stomach|Blood flow rate" id="699" />
-      <Map s="Q_sto" id="700" />
-      <Map s="Neighborhoods|Lung_int_Lung_cell|MOLECULE|Partition coefficient (interstitial/water)" id="701" />
-      <Map s="Neighborhoods|Lung_int_Lung_cell|MOLECULE|Partition coefficient (intracellular/water)" id="702" />
-      <Map s="Neighborhoods|Muscle_pls_Muscle_int|Surface area (plasma/interstitial)" id="703" />
-      <Map s="Neighborhoods|Muscle_int_Muscle_cell|MOLECULE|Partition coefficient (interstitial/water)" id="704" />
-      <Map s="Neighborhoods|Muscle_int_Muscle_cell|MOLECULE|Partition coefficient (intracellular/water)" id="705" />
-      <Map s="Neighborhoods|Pancreas_pls_Pancreas_int|Surface area (plasma/interstitial)" id="706" />
-      <Map s="Neighborhoods|Pancreas_int_Pancreas_cell|MOLECULE|Partition coefficient (interstitial/water)" id="707" />
-      <Map s="Neighborhoods|Pancreas_int_Pancreas_cell|MOLECULE|Partition coefficient (intracellular/water)" id="708" />
-      <Map s="Organism|LargeIntestine|Lymph flow rate (incl. mucosa)" id="709" />
-      <Map s="Q_Lymph_lin_incl_Mucosa" id="710" />
-      <Map s="Organism|Pancreas|Lymph flow rate" id="711" />
-      <Map s="Q_Lymph_pan" id="712" />
-      <Map s="Organism|SmallIntestine|Lymph flow rate (incl. mucosa)" id="713" />
-      <Map s="Q_Lymph_sin_incl_Mucosa" id="714" />
-      <Map s="Organism|Spleen|Lymph flow rate" id="715" />
-      <Map s="Q_Lymph_spl" id="716" />
-      <Map s="Organism|Stomach|Lymph flow rate" id="717" />
-      <Map s="Q_Lymph_sto" id="718" />
-      <Map s="Neighborhoods|Skin_pls_Skin_int|Surface area (plasma/interstitial)" id="719" />
-      <Map s="Neighborhoods|Skin_int_Skin_cell|MOLECULE|Partition coefficient (interstitial/water)" id="720" />
-      <Map s="Neighborhoods|Skin_int_Skin_cell|MOLECULE|Partition coefficient (intracellular/water)" id="721" />
-      <Map s="Neighborhoods|Spleen_pls_Spleen_int|Surface area (plasma/interstitial)" id="722" />
-      <Map s="Neighborhoods|Spleen_int_Spleen_cell|MOLECULE|Partition coefficient (interstitial/water)" id="723" />
-      <Map s="Neighborhoods|Spleen_int_Spleen_cell|MOLECULE|Partition coefficient (intracellular/water)" id="724" />
-      <Map s="Organism|Saliva|Volume" id="725" />
-      <Map s="V_slv" id="726" />
-      <Map s="FIRST_NEIGHBOR|..|Volume" id="727" />
-      <Map s="Organism|Surface/Volume ratio (blood cells)" id="728" />
-      <Map s="A_to_V_bc" id="729" />
-      <Map s="FIRST_NEIGHBOR|..|Fraction vascular" id="730" />
-      <Map s="f_vas_org" id="731" />
-      <Map s="Organism|SA proportionality factor" id="732" />
-      <Map s="V_bon" id="733" />
-      <Map s="..|P (intracellular-&gt;interstitial)" id="734" />
-      <Map s="P_cell_int" id="735" />
-      <Map s="..|..|Surface area (interstitial/intracellular)" id="736" />
-      <Map s="SA" id="737" />
-      <Map s="..|Partition coefficient (intracellular/plasma)" id="738" />
-      <Map s="K_cell_pls" id="739" />
-      <Map s="..|P (interstitial-&gt;intracellular)" id="740" />
-      <Map s="P_int_cell" id="741" />
-      <Map s="..|P_cell_int_factor" id="742" />
-      <Map s="P_cell_int_factor" id="743" />
-      <Map s="..|P_int_cell_factor" id="744" />
-      <Map s="P_int_cell_factor" id="745" />
-      <Map s="V_brn" id="746" />
-      <Map s="V_fat" id="747" />
-      <Map s="V_tes" id="748" />
-      <Map s="V_hrt" id="749" />
-      <Map s="FIRST_NEIGHBOR|MOLECULE|Concentration" id="750" />
-      <Map s="C_pls" id="751" />
-      <Map s="Concentration (molar)" id="752" />
-      <Map s="FIRST_NEIGHBOR|..|Blood flow rate" id="753" />
-      <Map s="FIRST_NEIGHBOR|pH" id="754" />
-      <Map s="SECOND_NEIGHBOR|pH" id="755" />
-      <Map s="..|pKa_pH_WS_cell_F1" id="756" />
-      <Map s="..|pKa_pH_WS_cell_F2" id="757" />
-      <Map s="..|pKa_pH_WS_cell_F3" id="758" />
-      <Map s="FIRST_NEIGHBOR|Effective surface area" id="759" />
-      <Map s="Aeff" id="760" />
-      <Map s="FIRST_NEIGHBOR|Liquid" id="761" />
-      <Map s="FIRST_NEIGHBOR|MOLECULE" id="762" />
-      <Map s="DrugLiquid" id="763" />
-      <Map s="Amount" id="764" />
-      <Map s="SECOND_NEIGHBOR|MOLECULE|Concentration" id="765" />
-      <Map s="DrugMucosa" id="766" />
-      <Map s="MOLECULE|Intestinal permeability (transcellular)" id="767" />
-      <Map s="MOLECULE|Molecular weight" id="768" />
-      <Map s="MW" id="769" />
-      <Map s="Molecular weight" id="770" />
-      <Map s="NEIGHBORHOOD|MOLECULE|P_int_trans_cell_lum_factor" id="771" />
-      <Map s="P_int_trans_cell_lum_factor" id="772" />
-      <Map s="NEIGHBORHOOD|MOLECULE|P_int_trans_lum_cell_factor" id="773" />
-      <Map s="P_int_trans_lum_cell_factor" id="774" />
-      <Map s="FIRST_NEIGHBOR|MOLECULE|Solubility" id="775" />
-      <Map s="FIRST_NEIGHBOR|..|OralApplicationsEnabled" id="776" />
-      <Map s="FIRST_NEIGHBOR|..|Transcellular absorption sink condition" id="777" />
-      <Map s="SinkCondition_trans" id="778" />
-      <Map s="..|pKa_pH_WS_cell_K1" id="779" />
-      <Map s="..|pKa_pH_WS_cell_K2" id="780" />
-      <Map s="..|pKa_pH_WS_cell_K3" id="781" />
-      <Map s="..|pKa_pH_WS_cell_K4" id="782" />
-      <Map s="..|pKa_pH_WS_cell_K5" id="783" />
-      <Map s="..|pKa_pH_WS_cell_K6" id="784" />
-      <Map s="..|pKa_pH_WS_cell_K7" id="785" />
-      <Map s="..|pKa_pH_WS_cell_K8" id="786" />
-      <Map s="MOLECULE|base_For_Pint_Factor" id="787" />
-      <Map s="MOLECULE|Use pH- and pKa-dependent penalty factor for charged molecule fraction" id="788" />
-      <Map s="UsePenaltyFactor" id="789" />
-      <Map s="Neighborhoods|UpperJejunum_int_UpperJejunum_cell|MOLECULE|Partition coefficient (intracellular/plasma)" id="790" />
-      <Map s="MOLECULE|Intestinal permeability (paracellular)" id="791" />
-      <Map s="P_int_para" id="792" />
-      <Map s="FIRST_NEIGHBOR|..|Paracellular absorption sink condition" id="793" />
-      <Map s="SinkCondition_para" id="794" />
-      <Map s="C_bc" id="795" />
-      <Map s="V_kid" id="796" />
-      <Map s="Neighborhoods|LowerJejunum_int_LowerJejunum_cell|MOLECULE|Partition coefficient (intracellular/plasma)" id="797" />
-      <Map s="Organism|Lumen|Caecum|MOLECULE|Oral mass absorbed segment" id="798" />
-      <Map s="MAbs_cae" id="799" />
-      <Map s="Organism|Lumen|ColonAscendens|MOLECULE|Oral mass absorbed segment" id="800" />
-      <Map s="MAbs_colasc" id="801" />
-      <Map s="Organism|Lumen|ColonDescendens|MOLECULE|Oral mass absorbed segment" id="802" />
-      <Map s="MAbs_coldesc" id="803" />
-      <Map s="Organism|Lumen|ColonSigmoid|MOLECULE|Oral mass absorbed segment" id="804" />
-      <Map s="MAbs_colsigm" id="805" />
-      <Map s="Organism|Lumen|ColonTransversum|MOLECULE|Oral mass absorbed segment" id="806" />
-      <Map s="MAbs_coltrans" id="807" />
-      <Map s="Organism|Lumen|Duodenum|MOLECULE|Oral mass absorbed segment" id="808" />
-      <Map s="MAbs_duo" id="809" />
-      <Map s="Organism|Lumen|LowerIleum|MOLECULE|Oral mass absorbed segment" id="810" />
-      <Map s="MAbs_lil" id="811" />
-      <Map s="Organism|Lumen|LowerJejunum|MOLECULE|Oral mass absorbed segment" id="812" />
-      <Map s="MAbs_lje" id="813" />
-      <Map s="Organism|Lumen|Rectum|MOLECULE|Oral mass absorbed segment" id="814" />
-      <Map s="MAbs_rect" id="815" />
-      <Map s="Organism|Lumen|UpperIleum|MOLECULE|Oral mass absorbed segment" id="816" />
-      <Map s="MAbs_uil" id="817" />
-      <Map s="Organism|Lumen|UpperJejunum|MOLECULE|Oral mass absorbed segment" id="818" />
-      <Map s="MAbs_uje" id="819" />
-      <Map s="V_sto" id="820" />
-      <Map s="Neighborhoods|UpperIleum_int_UpperIleum_cell|MOLECULE|Partition coefficient (intracellular/plasma)" id="821" />
-      <Map s="SECOND_NEIGHBOR|..|Blood flow rate" id="822" />
-      <Map s="Neighborhoods|LowerIleum_int_LowerIleum_cell|MOLECULE|Partition coefficient (intracellular/plasma)" id="823" />
-      <Map s="V_sin" id="824" />
-      <Map s="Organism|SmallIntestine|Volume (mucosa)" id="825" />
-      <Map s="FIRST_NEIGHBOR|..|Volume (mucosa)" id="826" />
-      <Map s="V_lin" id="827" />
-      <Map s="Organism|LargeIntestine|Volume (mucosa)" id="828" />
-      <Map s="Neighborhoods|Liver_int_Liver_cell|Surface area (interstitial/intracellular)" id="829" />
-      <Map s="SA_int_cell" id="830" />
-      <Map s="Neighborhoods|Liver_pls_Liver_bc|Surface area (blood cells/plasma)" id="831" />
-      <Map s="SA_pls_bc" id="832" />
-      <Map s="V_lng" id="833" />
-      <Map s="V_mus" id="834" />
-      <Map s="V_pan" id="835" />
-      <Map s="Neighborhoods|Rectum_int_Rectum_cell|MOLECULE|Partition coefficient (intracellular/plasma)" id="836" />
-      <Map s="V_skn" id="837" />
-      <Map s="V_spl" id="838" />
-      <Map s="..|SalivaPlasmaRatio" id="839" />
-      <Map s="R" id="840" />
-      <Map s="SECOND_NEIGHBOR|pH (saliva)" id="841" />
-      <Map s="pH_slv" id="842" />
-      <Map s="Organism|pH (plasma)" id="843" />
-      <Map s="pH_PLS" id="844" />
-      <Map s="Organism|Lumen|Duodenum|Effective surface area" id="845" />
-      <Map s="Organism|Lumen|Duodenum|Microvilli factor" id="846" />
-      <Map s="MicrovilliFactor" id="847" />
-      <Map s="MOLECULE|Mucosa permeability scale factor (transcellular)" id="848" />
-      <Map s="P_int_scalefactor" id="849" />
-      <Map s="Organism|Lumen|UpperJejunum|Effective surface area" id="850" />
-      <Map s="Organism|Lumen|UpperJejunum|Microvilli factor" id="851" />
-      <Map s="Organism|Lumen|LowerJejunum|Effective surface area" id="852" />
-      <Map s="Organism|Lumen|LowerJejunum|Microvilli factor" id="853" />
-      <Map s="Organism|Lumen|UpperIleum|Effective surface area" id="854" />
-      <Map s="Organism|Lumen|UpperIleum|Microvilli factor" id="855" />
-      <Map s="Organism|Lumen|LowerIleum|Effective surface area" id="856" />
-      <Map s="Organism|Lumen|LowerIleum|Microvilli factor" id="857" />
-      <Map s="Organism|Lumen|Caecum|Effective surface area" id="858" />
-      <Map s="Organism|Lumen|Caecum|Microvilli factor" id="859" />
-      <Map s="Organism|Lumen|ColonAscendens|Effective surface area" id="860" />
-      <Map s="Organism|Lumen|ColonAscendens|Microvilli factor" id="861" />
-      <Map s="Organism|Lumen|ColonTransversum|Effective surface area" id="862" />
-      <Map s="Organism|Lumen|ColonTransversum|Microvilli factor" id="863" />
-      <Map s="Organism|Lumen|ColonDescendens|Effective surface area" id="864" />
-      <Map s="Organism|Lumen|ColonDescendens|Microvilli factor" id="865" />
-      <Map s="Organism|Lumen|ColonSigmoid|Effective surface area" id="866" />
-      <Map s="Organism|Lumen|ColonSigmoid|Microvilli factor" id="867" />
-      <Map s="Organism|Lumen|Rectum|Effective surface area" id="868" />
-      <Map s="Organism|Lumen|Rectum|Microvilli factor" id="869" />
-      <Map s="Neighborhoods|Duodenum_int_Duodenum_cell|MOLECULE|Partition coefficient (intracellular/plasma)" id="870" />
-      <Map s="Neighborhoods|Caecum_int_Caecum_cell|MOLECULE|Partition coefficient (intracellular/plasma)" id="871" />
-      <Map s="Neighborhoods|ColonDescendens_int_ColonDescendens_cell|MOLECULE|Partition coefficient (intracellular/plasma)" id="872" />
-      <Map s="Neighborhoods|ColonTransversum_int_ColonTransversum_cell|MOLECULE|Partition coefficient (intracellular/plasma)" id="873" />
-      <Map s="Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|MOLECULE|Partition coefficient (intracellular/plasma)" id="874" />
-      <Map s="Neighborhoods|ColonAscendens_int_ColonAscendens_cell|MOLECULE|Partition coefficient (intracellular/plasma)" id="875" />
-      <Map s="Mean" id="876" />
-      <Map s="Deviation" id="877" />
-      <Map s="GeometricDeviation" id="878" />
+      <Map s=".." id="314" />
+      <Map s="M" id="315" />
+      <Map s="Amount" id="316" />
+      <Map s="..|Solubility" id="317" />
+      <Map s="MOLECULE|Enable supersaturation" id="318" />
+      <Map s="EnableSupersaturarion" id="319" />
+      <Map s="MOLECULE|Molecular weight" id="320" />
+      <Map s="MW" id="321" />
+      <Map s="Molecular weight" id="322" />
+      <Map s="..|..|Liquid" id="323" />
+      <Map s="alpha" id="324" />
+      <Map s="k" id="325" />
+      <Map s="inflow" id="326" />
+      <Map s="..|..|Stomach|Fractional steady state fill level" id="327" />
+      <Map s="alpha_p" id="328" />
+      <Map s="..|..|Stomach|Intestinal transit rate (absolute)" id="329" />
+      <Map s="k_p" id="330" />
+      <Map s="..|..|Stomach|Volume" id="331" />
+      <Map s="V_p" id="332" />
+      <Map s="..|..|..|Height" id="333" />
+      <Map s="..|r2_p0" id="334" />
+      <Map s="r2_p0" id="335" />
+      <Map s="..|r2_p1" id="336" />
+      <Map s="r2_p1" id="337" />
+      <Map s="..|Effective surface area enhancement factor" id="338" />
+      <Map s="AeffFactor" id="339" />
+      <Map s="Ageom" id="340" />
+      <Map s="Organism|Lumen|Effective surface area variability factor" id="341" />
+      <Map s="AeffVariabilityFactor" id="342" />
+      <Map s="..|Intestinal transit rate" id="343" />
+      <Map s="LuminalVelocity" id="344" />
+      <Map s="Organism|SmallIntestine|Small intestinal transit time factor" id="345" />
+      <Map s="SITT_fact" id="346" />
+      <Map s="..|L_p0" id="347" />
+      <Map s="L_p0" id="348" />
+      <Map s="..|L_p1" id="349" />
+      <Map s="L_p1" id="350" />
+      <Map s="..|Absorption of liquid" id="351" />
+      <Map s="Outflow" id="352" />
+      <Map s="LT_duo" id="353" />
+      <Map s="..|..|Stomach|Liquid transfer rate" id="354" />
+      <Map s="..|..|UpperJejunum|FillLevelFlag" id="355" />
+      <Map s="..|r1_p0" id="356" />
+      <Map s="r1_p0" id="357" />
+      <Map s="..|r1_p1" id="358" />
+      <Map s="r1_p1" id="359" />
+      <Map s="..|Thickness_p1" id="360" />
+      <Map s="Thickness_p1" id="361" />
+      <Map s="..|Thickness_p2" id="362" />
+      <Map s="Thickness_p2" id="363" />
+      <Map s="..|Thickness_p3" id="364" />
+      <Map s="Thickness_p3" id="365" />
+      <Map s="Inversed length" id="366" />
+      <Map s="Organism|SmallIntestine|Volume" id="367" />
+      <Map s="V_Intestine" id="368" />
+      <Map s="Neighborhoods|Lumen_duo_Duodenum_pls|MOLECULE|Sum of active process rates" id="369" />
+      <Map s="ActiveRates_para" id="370" />
+      <Map s="Amount per time" id="371" />
+      <Map s="Neighborhoods|Lumen_duo_Duodenum_cell|MOLECULE|Sum of active process rates" id="372" />
+      <Map s="ActiveRates_trans" id="373" />
+      <Map s="Neighborhoods|Lumen_duo_Duodenum_pls|MOLECULE|Sum of passive process rates" id="374" />
+      <Map s="PassiveRates_para" id="375" />
+      <Map s="Neighborhoods|Lumen_duo_Duodenum_cell|MOLECULE|Sum of passive process rates" id="376" />
+      <Map s="PassiveRates_trans" id="377" />
+      <Map s="..|..|Duodenum|Fractional steady state fill level" id="378" />
+      <Map s="..|..|Duodenum|Intestinal transit rate (absolute)" id="379" />
+      <Map s="..|..|Duodenum|Volume" id="380" />
+      <Map s="LT_uje" id="381" />
+      <Map s="..|..|Duodenum|Liquid transfer rate" id="382" />
+      <Map s="..|..|LowerJejunum|FillLevelFlag" id="383" />
+      <Map s="Neighborhoods|Lumen_uje_UpperJejunum_pls|MOLECULE|Sum of active process rates" id="384" />
+      <Map s="Neighborhoods|Lumen_uje_UpperJejunum_cell|MOLECULE|Sum of active process rates" id="385" />
+      <Map s="Neighborhoods|Lumen_uje_UpperJejunum_pls|MOLECULE|Sum of passive process rates" id="386" />
+      <Map s="Neighborhoods|Lumen_uje_UpperJejunum_cell|MOLECULE|Sum of passive process rates" id="387" />
+      <Map s="..|..|UpperJejunum|Fractional steady state fill level" id="388" />
+      <Map s="..|..|UpperJejunum|Intestinal transit rate (absolute)" id="389" />
+      <Map s="..|..|UpperJejunum|Volume" id="390" />
+      <Map s="LT_lje" id="391" />
+      <Map s="..|..|UpperJejunum|Liquid transfer rate" id="392" />
+      <Map s="..|..|UpperIleum|FillLevelFlag" id="393" />
+      <Map s="Neighborhoods|Lumen_lje_LowerJejunum_pls|MOLECULE|Sum of active process rates" id="394" />
+      <Map s="Neighborhoods|Lumen_lje_LowerJejunum_cell|MOLECULE|Sum of active process rates" id="395" />
+      <Map s="Neighborhoods|Lumen_lje_LowerJejunum_pls|MOLECULE|Sum of passive process rates" id="396" />
+      <Map s="Neighborhoods|Lumen_lje_LowerJejunum_cell|MOLECULE|Sum of passive process rates" id="397" />
+      <Map s="..|..|LowerJejunum|Fractional steady state fill level" id="398" />
+      <Map s="..|..|LowerJejunum|Intestinal transit rate (absolute)" id="399" />
+      <Map s="..|..|LowerJejunum|Volume" id="400" />
+      <Map s="LT_uil" id="401" />
+      <Map s="..|..|LowerJejunum|Liquid transfer rate" id="402" />
+      <Map s="..|..|LowerIleum|FillLevelFlag" id="403" />
+      <Map s="Neighborhoods|Lumen_uil_UpperIleum_pls|MOLECULE|Sum of active process rates" id="404" />
+      <Map s="Neighborhoods|Lumen_uil_UpperIleum_cell|MOLECULE|Sum of active process rates" id="405" />
+      <Map s="Neighborhoods|Lumen_uil_UpperIleum_pls|MOLECULE|Sum of passive process rates" id="406" />
+      <Map s="Neighborhoods|Lumen_uil_UpperIleum_cell|MOLECULE|Sum of passive process rates" id="407" />
+      <Map s="..|..|UpperIleum|Fractional steady state fill level" id="408" />
+      <Map s="..|..|UpperIleum|Intestinal transit rate (absolute)" id="409" />
+      <Map s="..|..|UpperIleum|Volume" id="410" />
+      <Map s="LT_lil" id="411" />
+      <Map s="..|..|UpperIleum|Liquid transfer rate" id="412" />
+      <Map s="..|..|Caecum|FillLevelFlag" id="413" />
+      <Map s="Neighborhoods|Lumen_lil_LowerIleum_pls|MOLECULE|Sum of active process rates" id="414" />
+      <Map s="Neighborhoods|Lumen_lil_LowerIleum_cell|MOLECULE|Sum of active process rates" id="415" />
+      <Map s="Neighborhoods|Lumen_lil_LowerIleum_pls|MOLECULE|Sum of passive process rates" id="416" />
+      <Map s="Neighborhoods|Lumen_lil_LowerIleum_cell|MOLECULE|Sum of passive process rates" id="417" />
+      <Map s="..|..|LowerIleum|Fractional steady state fill level" id="418" />
+      <Map s="..|..|LowerIleum|Intestinal transit rate (absolute)" id="419" />
+      <Map s="..|..|LowerIleum|Volume" id="420" />
+      <Map s="Organism|LargeIntestine|Large intestinal transit time factor" id="421" />
+      <Map s="LITT_fact" id="422" />
+      <Map s="LT_cae" id="423" />
+      <Map s="..|..|LowerIleum|Liquid transfer rate" id="424" />
+      <Map s="..|..|ColonAscendens|FillLevelFlag" id="425" />
+      <Map s="Organism|LargeIntestine|Volume" id="426" />
+      <Map s="Neighborhoods|Lumen_cae_Caecum_pls|MOLECULE|Sum of active process rates" id="427" />
+      <Map s="Neighborhoods|Lumen_cae_Caecum_cell|MOLECULE|Sum of active process rates" id="428" />
+      <Map s="Neighborhoods|Lumen_cae_Caecum_pls|MOLECULE|Sum of passive process rates" id="429" />
+      <Map s="Neighborhoods|Lumen_cae_Caecum_cell|MOLECULE|Sum of passive process rates" id="430" />
+      <Map s="..|..|Caecum|Fractional steady state fill level" id="431" />
+      <Map s="..|..|Caecum|Intestinal transit rate (absolute)" id="432" />
+      <Map s="..|..|Caecum|Volume" id="433" />
+      <Map s="LT_colasc" id="434" />
+      <Map s="..|..|Caecum|Liquid transfer rate" id="435" />
+      <Map s="..|..|ColonTransversum|FillLevelFlag" id="436" />
+      <Map s="Neighborhoods|Lumen_colasc_ColonAscendens_pls|MOLECULE|Sum of active process rates" id="437" />
+      <Map s="Neighborhoods|Lumen_colasc_ColonAscendens_cell|MOLECULE|Sum of active process rates" id="438" />
+      <Map s="Neighborhoods|Lumen_colasc_ColonAscendens_pls|MOLECULE|Sum of passive process rates" id="439" />
+      <Map s="Neighborhoods|Lumen_colasc_ColonAscendens_cell|MOLECULE|Sum of passive process rates" id="440" />
+      <Map s="..|..|ColonAscendens|Fractional steady state fill level" id="441" />
+      <Map s="..|..|ColonAscendens|Intestinal transit rate (absolute)" id="442" />
+      <Map s="..|..|ColonAscendens|Volume" id="443" />
+      <Map s="LT_coltrans" id="444" />
+      <Map s="..|..|ColonAscendens|Liquid transfer rate" id="445" />
+      <Map s="..|..|ColonDescendens|FillLevelFlag" id="446" />
+      <Map s="Neighborhoods|Lumen_coltrans_ColonTransversum_pls|MOLECULE|Sum of active process rates" id="447" />
+      <Map s="Neighborhoods|Lumen_coltrans_ColonTransversum_cell|MOLECULE|Sum of active process rates" id="448" />
+      <Map s="Neighborhoods|Lumen_coltrans_ColonTransversum_pls|MOLECULE|Sum of passive process rates" id="449" />
+      <Map s="Neighborhoods|Lumen_coltrans_ColonTransversum_cell|MOLECULE|Sum of passive process rates" id="450" />
+      <Map s="..|..|ColonTransversum|Fractional steady state fill level" id="451" />
+      <Map s="..|..|ColonTransversum|Intestinal transit rate (absolute)" id="452" />
+      <Map s="..|..|ColonTransversum|Volume" id="453" />
+      <Map s="LT_coldesc" id="454" />
+      <Map s="..|..|ColonTransversum|Liquid transfer rate" id="455" />
+      <Map s="..|..|ColonSigmoid|FillLevelFlag" id="456" />
+      <Map s="Neighborhoods|Lumen_coldesc_ColonDescendens_pls|MOLECULE|Sum of active process rates" id="457" />
+      <Map s="Neighborhoods|Lumen_coldesc_ColonDescendens_cell|MOLECULE|Sum of active process rates" id="458" />
+      <Map s="Neighborhoods|Lumen_coldesc_ColonDescendens_pls|MOLECULE|Sum of passive process rates" id="459" />
+      <Map s="Neighborhoods|Lumen_coldesc_ColonDescendens_cell|MOLECULE|Sum of passive process rates" id="460" />
+      <Map s="..|..|ColonDescendens|Fractional steady state fill level" id="461" />
+      <Map s="..|..|ColonDescendens|Intestinal transit rate (absolute)" id="462" />
+      <Map s="..|..|ColonDescendens|Volume" id="463" />
+      <Map s="LT_colsigm" id="464" />
+      <Map s="..|..|ColonDescendens|Liquid transfer rate" id="465" />
+      <Map s="..|..|Rectum|FillLevelFlag" id="466" />
+      <Map s="Neighborhoods|Lumen_colsigm_ColonSigmoid_pls|MOLECULE|Sum of active process rates" id="467" />
+      <Map s="Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|MOLECULE|Sum of active process rates" id="468" />
+      <Map s="Neighborhoods|Lumen_colsigm_ColonSigmoid_pls|MOLECULE|Sum of passive process rates" id="469" />
+      <Map s="Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|MOLECULE|Sum of passive process rates" id="470" />
+      <Map s="..|..|ColonSigmoid|Fractional steady state fill level" id="471" />
+      <Map s="..|..|ColonSigmoid|Intestinal transit rate (absolute)" id="472" />
+      <Map s="..|..|ColonSigmoid|Volume" id="473" />
+      <Map s="LT_rect" id="474" />
+      <Map s="..|..|ColonSigmoid|Liquid transfer rate" id="475" />
+      <Map s="Neighborhoods|Lumen_rect_Rectum_pls|MOLECULE|Sum of active process rates" id="476" />
+      <Map s="Neighborhoods|Lumen_rect_Rectum_cell|MOLECULE|Sum of active process rates" id="477" />
+      <Map s="Neighborhoods|Lumen_rect_Rectum_pls|MOLECULE|Sum of passive process rates" id="478" />
+      <Map s="Neighborhoods|Lumen_rect_Rectum_cell|MOLECULE|Sum of passive process rates" id="479" />
+      <Map s="..|..|Rectum|Liquid transfer rate" id="480" />
+      <Map s="LT_rec" id="481" />
+      <Map s="Neighborhoods|Stomach_pls_Stomach_int|Surface area (plasma/interstitial)" id="482" />
+      <Map s="Neighborhoods|Stomach_int_Stomach_cell|MOLECULE|Partition coefficient (interstitial/water)" id="483" />
+      <Map s="Neighborhoods|Stomach_int_Stomach_cell|MOLECULE|Partition coefficient (intracellular/water)" id="484" />
+      <Map s="..|Small intestinal transit time" id="485" />
+      <Map s="SITT" id="486" />
+      <Map s="..|Small intestinal transit time factor intercept" id="487" />
+      <Map s="P2" id="488" />
+      <Map s="..|Small intestinal transit time factor slope" id="489" />
+      <Map s="P1" id="490" />
+      <Map s="..|Fluid recirculation flow rate (incl. mucosa)" id="491" />
+      <Map s="J_iso_incl_Mucosa" id="492" />
+      <Map s="..|Mucosa|Duodenum|Fluid recirculation flow rate" id="493" />
+      <Map s="J_iso_duo" id="494" />
+      <Map s="..|Mucosa|LowerIleum|Fluid recirculation flow rate" id="495" />
+      <Map s="J_iso_lil" id="496" />
+      <Map s="..|Mucosa|LowerJejunum|Fluid recirculation flow rate" id="497" />
+      <Map s="J_iso_lje" id="498" />
+      <Map s="..|Mucosa|UpperIleum|Fluid recirculation flow rate" id="499" />
+      <Map s="J_iso_uil" id="500" />
+      <Map s="..|Mucosa|UpperJejunum|Fluid recirculation flow rate" id="501" />
+      <Map s="J_iso_uje" id="502" />
+      <Map s="..|Lymph flow rate (incl. mucosa)" id="503" />
+      <Map s="Q_lymph_incl_Mucosa" id="504" />
+      <Map s="..|Mucosa|Duodenum|Lymph flow rate" id="505" />
+      <Map s="Q_lymph_duo" id="506" />
+      <Map s="..|Mucosa|LowerIleum|Lymph flow rate" id="507" />
+      <Map s="Q_lymph_lil" id="508" />
+      <Map s="..|Mucosa|LowerJejunum|Lymph flow rate" id="509" />
+      <Map s="Q_lymph_lje" id="510" />
+      <Map s="..|Mucosa|UpperIleum|Lymph flow rate" id="511" />
+      <Map s="Q_lymph_uil" id="512" />
+      <Map s="..|Mucosa|UpperJejunum|Lymph flow rate" id="513" />
+      <Map s="Q_lymph_uje" id="514" />
+      <Map s="Neighborhoods|SmallIntestine_pls_SmallIntestine_int|Surface area (plasma/interstitial)" id="515" />
+      <Map s="..|Mucosa|Duodenum|Volume" id="516" />
+      <Map s="V_duo" id="517" />
+      <Map s="..|Mucosa|LowerIleum|Volume" id="518" />
+      <Map s="V_lil" id="519" />
+      <Map s="..|Mucosa|LowerJejunum|Volume" id="520" />
+      <Map s="V_lje" id="521" />
+      <Map s="..|Mucosa|UpperIleum|Volume" id="522" />
+      <Map s="V_uil" id="523" />
+      <Map s="..|Mucosa|UpperJejunum|Volume" id="524" />
+      <Map s="V_uje" id="525" />
+      <Map s="..|..|Volume (mucosa)" id="526" />
+      <Map s="V_Mucosa" id="527" />
+      <Map s="Neighborhoods|SmallIntestine_int_SmallIntestine_cell|MOLECULE|Partition coefficient (interstitial/water)" id="528" />
+      <Map s="Neighborhoods|SmallIntestine_int_SmallIntestine_cell|MOLECULE|Partition coefficient (intracellular/water)" id="529" />
+      <Map s="..|Fraction mucosa" id="530" />
+      <Map s="fractionMucosa" id="531" />
+      <Map s="..|..|..|..|Lumen|Duodenum|Volume (gut wall)" id="532" />
+      <Map s="V_GutWall" id="533" />
+      <Map s="..|..|..|Fluid recirculation flow rate (incl. mucosa)" id="534" />
+      <Map s="J_iso_intestine" id="535" />
+      <Map s="..|..|..|Volume" id="536" />
+      <Map s="V_intestine" id="537" />
+      <Map s="V_seg" id="538" />
+      <Map s="..|..|..|Lymph flow rate (incl. mucosa)" id="539" />
+      <Map s="Q_lymph_intestine" id="540" />
+      <Map s="Neighborhoods|Duodenum_pls_Duodenum_int|Surface area (plasma/interstitial)" id="541" />
+      <Map s="..|..|..|Blood flow rate" id="542" />
+      <Map s="..|Fraction of regional blood flow rate" id="543" />
+      <Map s="regionalFractQ" id="544" />
+      <Map s="..|..|..|Mucosa blood flow fraction" id="545" />
+      <Map s="fractQ" id="546" />
+      <Map s="Neighborhoods|Duodenum_int_Duodenum_cell|MOLECULE|Partition coefficient (interstitial/water)" id="547" />
+      <Map s="Neighborhoods|Duodenum_int_Duodenum_cell|MOLECULE|Partition coefficient (intracellular/water)" id="548" />
+      <Map s="..|..|..|..|Lumen|UpperJejunum|Volume (gut wall)" id="549" />
+      <Map s="Neighborhoods|UpperJejunum_pls_UpperJejunum_int|Surface area (plasma/interstitial)" id="550" />
+      <Map s="Neighborhoods|UpperJejunum_int_UpperJejunum_cell|MOLECULE|Partition coefficient (interstitial/water)" id="551" />
+      <Map s="Neighborhoods|UpperJejunum_int_UpperJejunum_cell|MOLECULE|Partition coefficient (intracellular/water)" id="552" />
+      <Map s="..|..|..|..|Lumen|LowerJejunum|Volume (gut wall)" id="553" />
+      <Map s="Neighborhoods|LowerJejunum_pls_LowerJejunum_int|Surface area (plasma/interstitial)" id="554" />
+      <Map s="Neighborhoods|LowerJejunum_int_LowerJejunum_cell|MOLECULE|Partition coefficient (interstitial/water)" id="555" />
+      <Map s="Neighborhoods|LowerJejunum_int_LowerJejunum_cell|MOLECULE|Partition coefficient (intracellular/water)" id="556" />
+      <Map s="..|..|..|..|Lumen|UpperIleum|Volume (gut wall)" id="557" />
+      <Map s="Neighborhoods|UpperIleum_pls_UpperIleum_int|Surface area (plasma/interstitial)" id="558" />
+      <Map s="Neighborhoods|UpperIleum_int_UpperIleum_cell|MOLECULE|Partition coefficient (interstitial/water)" id="559" />
+      <Map s="Neighborhoods|UpperIleum_int_UpperIleum_cell|MOLECULE|Partition coefficient (intracellular/water)" id="560" />
+      <Map s="..|..|..|..|Lumen|LowerIleum|Volume (gut wall)" id="561" />
+      <Map s="Neighborhoods|LowerIleum_pls_LowerIleum_int|Surface area (plasma/interstitial)" id="562" />
+      <Map s="Neighborhoods|LowerIleum_int_LowerIleum_cell|MOLECULE|Partition coefficient (interstitial/water)" id="563" />
+      <Map s="Neighborhoods|LowerIleum_int_LowerIleum_cell|MOLECULE|Partition coefficient (intracellular/water)" id="564" />
+      <Map s="..|Large intestinal transit time" id="565" />
+      <Map s="LITT" id="566" />
+      <Map s="..|Large intestinal transit time factor intercept" id="567" />
+      <Map s="..|Large intestinal transit time factor slope" id="568" />
+      <Map s="..|Mucosa|Caecum|Volume" id="569" />
+      <Map s="V_cae" id="570" />
+      <Map s="..|Mucosa|ColonAscendens|Volume" id="571" />
+      <Map s="V_ca" id="572" />
+      <Map s="..|Mucosa|ColonDescendens|Volume" id="573" />
+      <Map s="V_cd" id="574" />
+      <Map s="..|Mucosa|ColonSigmoid|Volume" id="575" />
+      <Map s="V_cs" id="576" />
+      <Map s="..|Mucosa|ColonTransversum|Volume" id="577" />
+      <Map s="V_ct" id="578" />
+      <Map s="..|Mucosa|Rectum|Volume" id="579" />
+      <Map s="V_rec" id="580" />
+      <Map s="..|Mucosa|Caecum|Fluid recirculation flow rate" id="581" />
+      <Map s="J_iso_cae" id="582" />
+      <Map s="..|Mucosa|ColonAscendens|Fluid recirculation flow rate" id="583" />
+      <Map s="J_iso_colasc" id="584" />
+      <Map s="..|Mucosa|ColonDescendens|Fluid recirculation flow rate" id="585" />
+      <Map s="J_iso_coldesc" id="586" />
+      <Map s="..|Mucosa|ColonSigmoid|Fluid recirculation flow rate" id="587" />
+      <Map s="J_iso_colsigm" id="588" />
+      <Map s="..|Mucosa|ColonTransversum|Fluid recirculation flow rate" id="589" />
+      <Map s="J_iso_coltrans" id="590" />
+      <Map s="..|Mucosa|Rectum|Fluid recirculation flow rate" id="591" />
+      <Map s="J_iso_rect" id="592" />
+      <Map s="..|Mucosa|Caecum|Lymph flow rate" id="593" />
+      <Map s="Q_lymph_cae" id="594" />
+      <Map s="..|Mucosa|ColonAscendens|Lymph flow rate" id="595" />
+      <Map s="Q_lymph_colasc" id="596" />
+      <Map s="..|Mucosa|ColonDescendens|Lymph flow rate" id="597" />
+      <Map s="Q_lymph_coldesc" id="598" />
+      <Map s="..|Mucosa|ColonSigmoid|Lymph flow rate" id="599" />
+      <Map s="Q_lymph_colsigm" id="600" />
+      <Map s="..|Mucosa|ColonTransversum|Lymph flow rate" id="601" />
+      <Map s="Q_lymph_coltrans" id="602" />
+      <Map s="..|Mucosa|Rectum|Lymph flow rate" id="603" />
+      <Map s="Q_lymph_rect" id="604" />
+      <Map s="Neighborhoods|LargeIntestine_pls_LargeIntestine_int|Surface area (plasma/interstitial)" id="605" />
+      <Map s="Neighborhoods|LargeIntestine_int_LargeIntestine_cell|MOLECULE|Partition coefficient (interstitial/water)" id="606" />
+      <Map s="Neighborhoods|LargeIntestine_int_LargeIntestine_cell|MOLECULE|Partition coefficient (intracellular/water)" id="607" />
+      <Map s="..|..|..|..|Lumen|Caecum|Volume (gut wall)" id="608" />
+      <Map s="Neighborhoods|Caecum_pls_Caecum_int|Surface area (plasma/interstitial)" id="609" />
+      <Map s="Neighborhoods|Caecum_int_Caecum_cell|MOLECULE|Partition coefficient (interstitial/water)" id="610" />
+      <Map s="Neighborhoods|Caecum_int_Caecum_cell|MOLECULE|Partition coefficient (intracellular/water)" id="611" />
+      <Map s="..|..|..|..|Lumen|ColonAscendens|Volume (gut wall)" id="612" />
+      <Map s="Neighborhoods|ColonAscendens_pls_ColonAscendens_int|Surface area (plasma/interstitial)" id="613" />
+      <Map s="Neighborhoods|ColonAscendens_int_ColonAscendens_cell|MOLECULE|Partition coefficient (interstitial/water)" id="614" />
+      <Map s="Neighborhoods|ColonAscendens_int_ColonAscendens_cell|MOLECULE|Partition coefficient (intracellular/water)" id="615" />
+      <Map s="..|..|..|..|Lumen|ColonTransversum|Volume (gut wall)" id="616" />
+      <Map s="Neighborhoods|ColonTransversum_pls_ColonTransversum_int|Surface area (plasma/interstitial)" id="617" />
+      <Map s="Neighborhoods|ColonTransversum_int_ColonTransversum_cell|MOLECULE|Partition coefficient (interstitial/water)" id="618" />
+      <Map s="Neighborhoods|ColonTransversum_int_ColonTransversum_cell|MOLECULE|Partition coefficient (intracellular/water)" id="619" />
+      <Map s="..|..|..|..|Lumen|ColonDescendens|Volume (gut wall)" id="620" />
+      <Map s="Neighborhoods|ColonDescendens_pls_ColonDescendens_int|Surface area (plasma/interstitial)" id="621" />
+      <Map s="Neighborhoods|ColonDescendens_int_ColonDescendens_cell|MOLECULE|Partition coefficient (interstitial/water)" id="622" />
+      <Map s="Neighborhoods|ColonDescendens_int_ColonDescendens_cell|MOLECULE|Partition coefficient (intracellular/water)" id="623" />
+      <Map s="..|..|..|..|Lumen|ColonSigmoid|Volume (gut wall)" id="624" />
+      <Map s="Neighborhoods|ColonSigmoid_pls_ColonSigmoid_int|Surface area (plasma/interstitial)" id="625" />
+      <Map s="Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|MOLECULE|Partition coefficient (interstitial/water)" id="626" />
+      <Map s="Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|MOLECULE|Partition coefficient (intracellular/water)" id="627" />
+      <Map s="..|..|..|..|Lumen|Rectum|Volume (gut wall)" id="628" />
+      <Map s="Neighborhoods|Rectum_pls_Rectum_int|Surface area (plasma/interstitial)" id="629" />
+      <Map s="Neighborhoods|Rectum_int_Rectum_cell|MOLECULE|Partition coefficient (interstitial/water)" id="630" />
+      <Map s="Neighborhoods|Rectum_int_Rectum_cell|MOLECULE|Partition coefficient (intracellular/water)" id="631" />
+      <Map s="Neighborhoods|Liver_pls_Liver_int|Surface area (plasma/interstitial)" id="632" />
+      <Map s="..|..|Allometric scale factor" id="633" />
+      <Map s="Liver_Parameter" id="634" />
+      <Map s="..|..|Density (tissue)" id="635" />
+      <Map s="..|..|Fraction of blood for sampling" id="636" />
+      <Map s="Organism|Liver|Fraction of periportal zone" id="637" />
+      <Map s="f_periportal" id="638" />
+      <Map s="Organism|Liver|Is liver zonated" id="639" />
+      <Map s="IsLiverZonated" id="640" />
+      <Map s="Organism|Liver|Volume" id="641" />
+      <Map s="V_liv" id="642" />
+      <Map s="..|..|Flow fraction via large pores" id="643" />
+      <Map s="..|..|Fluid recirculation flow rate" id="644" />
+      <Map s="J_iso" id="645" />
+      <Map s="..|..|Hydraulic conductivity" id="646" />
+      <Map s="Hydraulic conductivity" id="647" />
+      <Map s="..|..|Lymph flow rate" id="648" />
+      <Map s="..|..|Radius (large pores)" id="649" />
+      <Map s="..|..|Radius (small pores)" id="650" />
+      <Map s="Neighborhoods|Periportal_pls_Periportal_int|Surface area (plasma/interstitial)" id="651" />
+      <Map s="..|..|Vf (lipid)" id="652" />
+      <Map s="..|..|Vf (neutral lipid)-PT" id="653" />
+      <Map s="..|..|Vf (phospholipid)-PT" id="654" />
+      <Map s="..|..|Vf (protein)" id="655" />
+      <Map s="..|..|Albumin ratio (tissue/plasma)" id="656" />
+      <Map s="..|..|Albumin ratio (tissue/plasma)-PT" id="657" />
+      <Map s="..|..|Lipoprotein ratio (tissue/plasma)" id="658" />
+      <Map s="..|..|Microsomal protein mass/g tissue" id="659" />
+      <Map s="Mass per tissue" id="660" />
+      <Map s="..|..|Number of cells/g tissue" id="661" />
+      <Map s="Count per mass" id="662" />
+      <Map s="..|..|Vf (water)" id="663" />
+      <Map s="..|..|Vf (water)-PT" id="664" />
+      <Map s="..|..|Vf (neutral lipid)-RR" id="665" />
+      <Map s="..|..|Vf (neutral lipid)-WS" id="666" />
+      <Map s="..|..|Vf (neutral phospholipid)-RR" id="667" />
+      <Map s="..|..|Vf (neutral phospholipid, plasma)-WS" id="668" />
+      <Map s="..|..|Vf (extracellular water)-RR" id="669" />
+      <Map s="..|..|Vf (protein)-WS" id="670" />
+      <Map s="..|..|Vf (intracellular water)-RR" id="671" />
+      <Map s="..|..|Vf (water)-WS" id="672" />
+      <Map s="..|..|Acidic phospholipids [mg/g] - RR" id="673" />
+      <Map s="..|..|Vf (acidic phospholipids)-WS" id="674" />
+      <Map s="..|..|Specific blood flow rate" id="675" />
+      <Map s="..|..|Blood flow rate" id="676" />
+      <Map s="Neighborhoods|Periportal_int_Periportal_cell|MOLECULE|Partition coefficient (interstitial/water)" id="677" />
+      <Map s="Organism|Liver|Intracellular|pH" id="678" />
+      <Map s="pH_cell_Liver" id="679" />
+      <Map s="Neighborhoods|Periportal_int_Periportal_cell|MOLECULE|Partition coefficient (intracellular/water)" id="680" />
+      <Map s="Neighborhoods|Pericentral_pls_Pericentral_int|Surface area (plasma/interstitial)" id="681" />
+      <Map s="Neighborhoods|Lung_pls_Lung_int|Surface area (plasma/interstitial)" id="682" />
+      <Map s="Neighborhoods|Lung_int_Lung_cell|MOLECULE|Partition coefficient (interstitial/water)" id="683" />
+      <Map s="Neighborhoods|Lung_int_Lung_cell|MOLECULE|Partition coefficient (intracellular/water)" id="684" />
+      <Map s="Neighborhoods|Muscle_pls_Muscle_int|Surface area (plasma/interstitial)" id="685" />
+      <Map s="Neighborhoods|Muscle_int_Muscle_cell|MOLECULE|Partition coefficient (interstitial/water)" id="686" />
+      <Map s="Neighborhoods|Muscle_int_Muscle_cell|MOLECULE|Partition coefficient (intracellular/water)" id="687" />
+      <Map s="Neighborhoods|Pancreas_pls_Pancreas_int|Surface area (plasma/interstitial)" id="688" />
+      <Map s="Neighborhoods|Pancreas_int_Pancreas_cell|MOLECULE|Partition coefficient (interstitial/water)" id="689" />
+      <Map s="Neighborhoods|Pancreas_int_Pancreas_cell|MOLECULE|Partition coefficient (intracellular/water)" id="690" />
+      <Map s="Organism|LargeIntestine|Lymph flow rate (incl. mucosa)" id="691" />
+      <Map s="Q_Lymph_lin_incl_Mucosa" id="692" />
+      <Map s="Organism|Pancreas|Lymph flow rate" id="693" />
+      <Map s="Q_Lymph_pan" id="694" />
+      <Map s="Organism|SmallIntestine|Lymph flow rate (incl. mucosa)" id="695" />
+      <Map s="Q_Lymph_sin_incl_Mucosa" id="696" />
+      <Map s="Organism|Spleen|Lymph flow rate" id="697" />
+      <Map s="Q_Lymph_spl" id="698" />
+      <Map s="Organism|Stomach|Lymph flow rate" id="699" />
+      <Map s="Q_Lymph_sto" id="700" />
+      <Map s="Organism|LargeIntestine|Blood flow rate" id="701" />
+      <Map s="Q_lin" id="702" />
+      <Map s="Organism|Pancreas|Blood flow rate" id="703" />
+      <Map s="Q_pan" id="704" />
+      <Map s="Organism|SmallIntestine|Blood flow rate" id="705" />
+      <Map s="Q_sin" id="706" />
+      <Map s="Organism|Spleen|Blood flow rate" id="707" />
+      <Map s="Q_spl" id="708" />
+      <Map s="Organism|Stomach|Blood flow rate" id="709" />
+      <Map s="Q_sto" id="710" />
+      <Map s="Neighborhoods|Skin_pls_Skin_int|Surface area (plasma/interstitial)" id="711" />
+      <Map s="Neighborhoods|Skin_int_Skin_cell|MOLECULE|Partition coefficient (interstitial/water)" id="712" />
+      <Map s="Neighborhoods|Skin_int_Skin_cell|MOLECULE|Partition coefficient (intracellular/water)" id="713" />
+      <Map s="Neighborhoods|Spleen_pls_Spleen_int|Surface area (plasma/interstitial)" id="714" />
+      <Map s="Neighborhoods|Spleen_int_Spleen_cell|MOLECULE|Partition coefficient (interstitial/water)" id="715" />
+      <Map s="Neighborhoods|Spleen_int_Spleen_cell|MOLECULE|Partition coefficient (intracellular/water)" id="716" />
+      <Map s="Organism|Saliva|Volume" id="717" />
+      <Map s="V_slv" id="718" />
+      <Map s="FIRST_NEIGHBOR|..|Volume" id="719" />
+      <Map s="Organism|Surface/Volume ratio (blood cells)" id="720" />
+      <Map s="A_to_V_bc" id="721" />
+      <Map s="V_bon" id="722" />
+      <Map s="..|P_int_cell_factor" id="723" />
+      <Map s="P_int_cell_factor" id="724" />
+      <Map s="..|P_cell_int_factor" id="725" />
+      <Map s="P_cell_int_factor" id="726" />
+      <Map s="..|P (interstitial-&gt;intracellular)" id="727" />
+      <Map s="P_int_cell" id="728" />
+      <Map s="..|..|Surface area (interstitial/intracellular)" id="729" />
+      <Map s="SA" id="730" />
+      <Map s="..|P (intracellular-&gt;interstitial)" id="731" />
+      <Map s="P_cell_int" id="732" />
+      <Map s="..|Partition coefficient (intracellular/plasma)" id="733" />
+      <Map s="K_cell_pls" id="734" />
+      <Map s="FIRST_NEIGHBOR|..|Fraction vascular" id="735" />
+      <Map s="f_vas_org" id="736" />
+      <Map s="Organism|SA proportionality factor" id="737" />
+      <Map s="V_brn" id="738" />
+      <Map s="V_fat" id="739" />
+      <Map s="V_tes" id="740" />
+      <Map s="V_hrt" id="741" />
+      <Map s="V_kid" id="742" />
+      <Map s="FIRST_NEIGHBOR|Effective surface area" id="743" />
+      <Map s="Aeff" id="744" />
+      <Map s="SECOND_NEIGHBOR|MOLECULE|Concentration" id="745" />
+      <Map s="DrugMucosa" id="746" />
+      <Map s="Concentration (molar)" id="747" />
+      <Map s="FIRST_NEIGHBOR|MOLECULE|Effective concentration in lumen" id="748" />
+      <Map s="EffectiveLumenConcentration" id="749" />
+      <Map s="MOLECULE|Intestinal permeability (paracellular)" id="750" />
+      <Map s="P_int_para" id="751" />
+      <Map s="FIRST_NEIGHBOR|..|OralApplicationsEnabled" id="752" />
+      <Map s="FIRST_NEIGHBOR|..|Paracellular absorption sink condition" id="753" />
+      <Map s="SinkCondition_para" id="754" />
+      <Map s="MOLECULE|Intestinal permeability (transcellular)" id="755" />
+      <Map s="NEIGHBORHOOD|MOLECULE|P_int_trans_cell_lum_factor" id="756" />
+      <Map s="P_int_trans_cell_lum_factor" id="757" />
+      <Map s="NEIGHBORHOOD|MOLECULE|P_int_trans_lum_cell_factor" id="758" />
+      <Map s="P_int_trans_lum_cell_factor" id="759" />
+      <Map s="FIRST_NEIGHBOR|..|Transcellular absorption sink condition" id="760" />
+      <Map s="SinkCondition_trans" id="761" />
+      <Map s="..|pKa_pH_WS_cell_K1" id="762" />
+      <Map s="..|pKa_pH_WS_cell_K2" id="763" />
+      <Map s="..|pKa_pH_WS_cell_K3" id="764" />
+      <Map s="..|pKa_pH_WS_cell_K4" id="765" />
+      <Map s="..|pKa_pH_WS_cell_K5" id="766" />
+      <Map s="..|pKa_pH_WS_cell_K6" id="767" />
+      <Map s="..|pKa_pH_WS_cell_K7" id="768" />
+      <Map s="..|pKa_pH_WS_cell_K8" id="769" />
+      <Map s="MOLECULE|Use pH- and pKa-dependent penalty factor for charged molecule fraction" id="770" />
+      <Map s="UsePenaltyFactor" id="771" />
+      <Map s="MOLECULE|base_For_Pint_Factor" id="772" />
+      <Map s="Neighborhoods|UpperJejunum_int_UpperJejunum_cell|MOLECULE|Partition coefficient (intracellular/plasma)" id="773" />
+      <Map s="SECOND_NEIGHBOR|pH" id="774" />
+      <Map s="..|pKa_pH_WS_cell_F1" id="775" />
+      <Map s="..|pKa_pH_WS_cell_F2" id="776" />
+      <Map s="..|pKa_pH_WS_cell_F3" id="777" />
+      <Map s="FIRST_NEIGHBOR|pH" id="778" />
+      <Map s="FIRST_NEIGHBOR|MOLECULE|Concentration" id="779" />
+      <Map s="C_pls" id="780" />
+      <Map s="FIRST_NEIGHBOR|..|Blood flow rate" id="781" />
+      <Map s="C_bc" id="782" />
+      <Map s="Neighborhoods|LowerJejunum_int_LowerJejunum_cell|MOLECULE|Partition coefficient (intracellular/plasma)" id="783" />
+      <Map s="Organism|Lumen|Caecum|MOLECULE|Oral mass absorbed segment" id="784" />
+      <Map s="MAbs_cae" id="785" />
+      <Map s="Organism|Lumen|ColonAscendens|MOLECULE|Oral mass absorbed segment" id="786" />
+      <Map s="MAbs_colasc" id="787" />
+      <Map s="Organism|Lumen|ColonDescendens|MOLECULE|Oral mass absorbed segment" id="788" />
+      <Map s="MAbs_coldesc" id="789" />
+      <Map s="Organism|Lumen|ColonSigmoid|MOLECULE|Oral mass absorbed segment" id="790" />
+      <Map s="MAbs_colsigm" id="791" />
+      <Map s="Organism|Lumen|ColonTransversum|MOLECULE|Oral mass absorbed segment" id="792" />
+      <Map s="MAbs_coltrans" id="793" />
+      <Map s="Organism|Lumen|Duodenum|MOLECULE|Oral mass absorbed segment" id="794" />
+      <Map s="MAbs_duo" id="795" />
+      <Map s="Organism|Lumen|LowerIleum|MOLECULE|Oral mass absorbed segment" id="796" />
+      <Map s="MAbs_lil" id="797" />
+      <Map s="Organism|Lumen|LowerJejunum|MOLECULE|Oral mass absorbed segment" id="798" />
+      <Map s="MAbs_lje" id="799" />
+      <Map s="Organism|Lumen|Rectum|MOLECULE|Oral mass absorbed segment" id="800" />
+      <Map s="MAbs_rect" id="801" />
+      <Map s="Organism|Lumen|UpperIleum|MOLECULE|Oral mass absorbed segment" id="802" />
+      <Map s="MAbs_uil" id="803" />
+      <Map s="Organism|Lumen|UpperJejunum|MOLECULE|Oral mass absorbed segment" id="804" />
+      <Map s="MAbs_uje" id="805" />
+      <Map s="V_sto" id="806" />
+      <Map s="Neighborhoods|UpperIleum_int_UpperIleum_cell|MOLECULE|Partition coefficient (intracellular/plasma)" id="807" />
+      <Map s="V_sin" id="808" />
+      <Map s="Organism|SmallIntestine|Volume (mucosa)" id="809" />
+      <Map s="FIRST_NEIGHBOR|..|Volume (mucosa)" id="810" />
+      <Map s="SECOND_NEIGHBOR|..|Blood flow rate" id="811" />
+      <Map s="Neighborhoods|LowerIleum_int_LowerIleum_cell|MOLECULE|Partition coefficient (intracellular/plasma)" id="812" />
+      <Map s="V_lin" id="813" />
+      <Map s="Organism|LargeIntestine|Volume (mucosa)" id="814" />
+      <Map s="Neighborhoods|Liver_int_Liver_cell|Surface area (interstitial/intracellular)" id="815" />
+      <Map s="SA_int_cell" id="816" />
+      <Map s="Neighborhoods|Liver_pls_Liver_bc|Surface area (blood cells/plasma)" id="817" />
+      <Map s="SA_pls_bc" id="818" />
+      <Map s="V_lng" id="819" />
+      <Map s="V_mus" id="820" />
+      <Map s="V_pan" id="821" />
+      <Map s="Neighborhoods|Rectum_int_Rectum_cell|MOLECULE|Partition coefficient (intracellular/plasma)" id="822" />
+      <Map s="V_skn" id="823" />
+      <Map s="V_spl" id="824" />
+      <Map s="..|SalivaPlasmaRatio" id="825" />
+      <Map s="R" id="826" />
+      <Map s="SECOND_NEIGHBOR|pH (saliva)" id="827" />
+      <Map s="pH_slv" id="828" />
+      <Map s="Organism|pH (plasma)" id="829" />
+      <Map s="pH_PLS" id="830" />
+      <Map s="Organism|Lumen|Duodenum|Effective surface area" id="831" />
+      <Map s="Organism|Lumen|Duodenum|Microvilli factor" id="832" />
+      <Map s="MicrovilliFactor" id="833" />
+      <Map s="MOLECULE|Mucosa permeability scale factor (transcellular)" id="834" />
+      <Map s="P_int_scalefactor" id="835" />
+      <Map s="Organism|Lumen|UpperJejunum|Effective surface area" id="836" />
+      <Map s="Organism|Lumen|UpperJejunum|Microvilli factor" id="837" />
+      <Map s="Organism|Lumen|LowerJejunum|Effective surface area" id="838" />
+      <Map s="Organism|Lumen|LowerJejunum|Microvilli factor" id="839" />
+      <Map s="Organism|Lumen|UpperIleum|Effective surface area" id="840" />
+      <Map s="Organism|Lumen|UpperIleum|Microvilli factor" id="841" />
+      <Map s="Organism|Lumen|LowerIleum|Effective surface area" id="842" />
+      <Map s="Organism|Lumen|LowerIleum|Microvilli factor" id="843" />
+      <Map s="Organism|Lumen|Caecum|Effective surface area" id="844" />
+      <Map s="Organism|Lumen|Caecum|Microvilli factor" id="845" />
+      <Map s="Organism|Lumen|ColonAscendens|Effective surface area" id="846" />
+      <Map s="Organism|Lumen|ColonAscendens|Microvilli factor" id="847" />
+      <Map s="Organism|Lumen|ColonTransversum|Effective surface area" id="848" />
+      <Map s="Organism|Lumen|ColonTransversum|Microvilli factor" id="849" />
+      <Map s="Organism|Lumen|ColonDescendens|Effective surface area" id="850" />
+      <Map s="Organism|Lumen|ColonDescendens|Microvilli factor" id="851" />
+      <Map s="Organism|Lumen|ColonSigmoid|Effective surface area" id="852" />
+      <Map s="Organism|Lumen|ColonSigmoid|Microvilli factor" id="853" />
+      <Map s="Organism|Lumen|Rectum|Effective surface area" id="854" />
+      <Map s="Organism|Lumen|Rectum|Microvilli factor" id="855" />
+      <Map s="Neighborhoods|Duodenum_int_Duodenum_cell|MOLECULE|Partition coefficient (intracellular/plasma)" id="856" />
+      <Map s="Neighborhoods|Caecum_int_Caecum_cell|MOLECULE|Partition coefficient (intracellular/plasma)" id="857" />
+      <Map s="Neighborhoods|ColonAscendens_int_ColonAscendens_cell|MOLECULE|Partition coefficient (intracellular/plasma)" id="858" />
+      <Map s="Neighborhoods|ColonTransversum_int_ColonTransversum_cell|MOLECULE|Partition coefficient (intracellular/plasma)" id="859" />
+      <Map s="Neighborhoods|ColonDescendens_int_ColonDescendens_cell|MOLECULE|Partition coefficient (intracellular/plasma)" id="860" />
+      <Map s="Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|MOLECULE|Partition coefficient (intracellular/plasma)" id="861" />
+      <Map s="Mean" id="862" />
+      <Map s="Deviation" id="863" />
+      <Map s="GeometricDeviation" id="864" />
     </StringMap>
   </FormulaCache>
 </SpatialStructure>
\ No newline at end of file
diff --git a/src/Data/Templates/IV Bolus (mg).pkml b/src/Data/Templates/IV Bolus (mg).pkml
index 918fa1caa..eaf3d98c3 100644
--- a/src/Data/Templates/IV Bolus (mg).pkml	
+++ b/src/Data/Templates/IV Bolus (mg).pkml	
@@ -1,56 +1,56 @@
 <?xml version="1.0" encoding="utf-8"?>
-<EventGroupBuildingBlock id="x1G9UC7QFUujs_PmVSrRqQ" name="IV Bolus (mg)" icon="EventGroup" bbVersion="0" version="13">
-  <Creation createdAt="5248308555567384780" createdBy="EZZJY" creationMode="New" origin="PKSim" version="7.3.0" internalVersion="74" />
+<EventGroupBuildingBlock id="5wtovTXiGk-2f4gS6_p7FA" name="IV Bolus (mg)" icon="EventGroup" bbVersion="0" version="14">
+  <Creation createdAt="5248852327733452926" createdBy="Michael" creationMode="New" origin="PKSim" version="9.0" internalVersion="77" />
   <Builders>
-    <EventGroupBuilder id="jVwm4SY5f02UybiWOwVBTw" name="Applications" icon="Applications" mode="Logical" containerType="EventGroup">
+    <EventGroupBuilder id="pPfd3G1O3kmAVNWm-jHieA" name="Applications" icon="Applications" mode="Logical" containerType="EventGroup">
       <Children>
-        <EventGroupBuilder id="CCBd3tKntk2XrcGq059ezA" name="Protocol" mode="Logical" containerType="EventGroup">
+        <EventGroupBuilder id="i0h8qmQS3kKVKm3CofdL9Q" name="Protocol" mode="Logical" containerType="EventGroup">
           <Children>
-            <ApplicationBuilder id="yV_44MmkwUe3CI0_y8dTeA" name="Application_1" icon="IntravenousBolus" mode="Logical" containerType="Application" eventGroupType="IntravenousBolus" moleculeName="Standard Molecule">
+            <ApplicationBuilder id="I_hpgeguLEyWj-3x6Outaw" name="Application_1" icon="IntravenousBolus" mode="Logical" containerType="Application" eventGroupType="IntravenousBolus" moleculeName="Standard Molecule">
               <Tags>
                 <Tag value="Application" />
                 <Tag value="Application_1" />
                 <Tag value="ApplicationRoot" />
               </Tags>
               <Children>
-                <EventBuilder id="SgjOS_Pz0kuv4Pdnm7W2gg" name="Application_StartEvent" oneTime="1" formula="pZP9fpeAfUi6gNXprrocxg">
+                <EventBuilder id="35sP1uG_n0-FilazqtmHTA" name="Application_StartEvent" oneTime="1" formula="MYzQRIaANkuoby1aAKG2JQ">
                   <Tags>
                     <Tag value="Application" />
                     <Tag value="Application_1" />
                   </Tags>
                   <Assignments>
-                    <EventAssignmentBuilder id="hvI7ryjhgUu4MhrKEVKOHw" name="Assignment_1" useAsValue="1" dimension="Amount" formula="LGN4ZrlpokWXVHZ-S6YuGA">
+                    <EventAssignmentBuilder id="kdnK0KHQaEyxz_fTSplbSw" name="Assignment_1" useAsValue="1" dimension="Amount" formula="FE3rzCm6CUCQ0rxE5jgnVA">
                       <ObjectPath path="0" />
                     </EventAssignmentBuilder>
                   </Assignments>
                 </EventBuilder>
-                <Container id="7LXWKFEPDkiumcyY793L4A" name="ProtocolSchemaItem" mode="Logical" containerType="Other">
+                <Container id="EL9JL5X1TUmo3P30cT44og" name="ProtocolSchemaItem" mode="Logical" containerType="Other">
                   <Tags>
                     <Tag value="Application" />
                     <Tag value="Application_1" />
                   </Tags>
                   <Children>
-                    <Parameter id="fFkoe1lXnUq9ASVLTFE_ZA" name="Start time" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0" displayUnit="h">
+                    <Parameter id="KU6m07AetUqPb4qsw_jPRQ" name="Start time" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0" displayUnit="h">
                       <Info min="0" flag="58" seq="1" ref="0" bb="16" group="88" />
                     </Parameter>
-                    <Parameter id="hn4ABZLXekCI08gjpC3Q0g" name="DrugMass" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" formula="3mpberD2QU6IiFQUl7vKaw" isDefault="1" displayUnit="µmol">
-                      <Tags>
-                        <Tag value="MOLECULE" />
-                      </Tags>
-                      <Info min="0" flag="54" seq="2" ref="0" bb="2" group="88" />
+                    <Parameter id="xNd0uZXv8kuI0dYtc-YjMA" name="Dose" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1E-06" displayUnit="mg">
+                      <Info min="0" flag="58" seq="2" ref="0" bb="16" group="88" />
                     </Parameter>
-                    <Parameter id="muR-ultih0eMRt864JARdQ" name="DosePerBodySurfaceArea" icon="Parameter" persistable="0" isFixedValue="0" dim="Dose per body surface area" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0" displayUnit="mg/m²">
+                    <Parameter id="9gzflaarJEq7cPe1EBiNCQ" name="DosePerBodySurfaceArea" icon="Parameter" persistable="0" isFixedValue="0" dim="Dose per body surface area" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0" displayUnit="mg/m²">
                       <Info min="0" flag="50" seq="2" ref="0" bb="2" group="88" />
                     </Parameter>
-                    <Parameter id="cHpTEXReyUWujxlDNGGD2A" name="DosePerBodyWeight" icon="Parameter" persistable="0" isFixedValue="0" dim="Dose per body weight" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0" displayUnit="mg/kg">
+                    <Parameter id="h5IEtQr3SEKmy8bqtwmVVw" name="DosePerBodyWeight" icon="Parameter" persistable="0" isFixedValue="0" dim="Dose per body weight" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0" displayUnit="mg/kg">
                       <Info min="0" flag="50" seq="2" ref="0" bb="2" group="88" />
                     </Parameter>
-                    <Parameter id="Oc-siWqObUqgagRkeajirg" name="Dose" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1E-06" displayUnit="mg">
-                      <Info min="0" flag="58" seq="2" ref="0" bb="16" group="88" />
+                    <Parameter id="JdvRCivb-k-rqPUDHfm3pQ" name="DrugMass" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" formula="exTU1rxt00uhyjwc2PnIIg" isDefault="1" displayUnit="µmol">
+                      <Tags>
+                        <Tag value="MOLECULE" />
+                      </Tags>
+                      <Info min="0" flag="54" seq="2" ref="0" bb="2" group="88" />
                     </Parameter>
                   </Children>
                 </Container>
-                <ApplicationMoleculeBuilder id="m_ZD2o92bEONl2C56oX5fw" name="Application_1" formula="zicZTpTVAUSr4dRWZsFhIg">
+                <ApplicationMoleculeBuilder id="mnUmTwVmJkKEGYYpGB_b-w" name="Application_1" formula="4opeT6MLU0yYrl1Z823qQw">
                   <RelativeContainerPath path="1" />
                 </ApplicationMoleculeBuilder>
               </Children>
@@ -73,25 +73,25 @@
   </Builders>
   <FormulaCache>
     <Formulas>
-      <Formula id="LGN4ZrlpokWXVHZ-S6YuGA" name="IV_Bolus" dim="Amount" formula="M + DrugMass">
+      <Formula id="FE3rzCm6CUCQ0rxE5jgnVA" name="IV_Bolus" dim="Amount" formula="M + DrugMass">
         <Paths>
           <Path path="0" as="2" dim="3" />
           <Path path="4" as="5" dim="3" />
         </Paths>
       </Formula>
-      <Formula id="pZP9fpeAfUi6gNXprrocxg" name="AppStartEventCondition" formula="Time=StartTime">
+      <Formula id="MYzQRIaANkuoby1aAKG2JQ" name="AppStartEventCondition" formula="Time=StartTime">
         <Paths>
           <Path path="6" as="7" dim="8" />
           <TimePath />
         </Paths>
       </Formula>
-      <Formula id="3mpberD2QU6IiFQUl7vKaw" name="PARAM_Application_DrugMass" dim="Amount" formula="Dose / MW">
+      <Formula id="exTU1rxt00uhyjwc2PnIIg" name="PARAM_Application_DrugMass" dim="Amount" formula="Dose / MW">
         <Paths>
           <Path path="9" as="10" dim="11" />
           <Path path="12" as="13" dim="14" />
         </Paths>
       </Formula>
-      <Formula id="zicZTpTVAUSr4dRWZsFhIg" name="DrugMass" dim="Amount" formula="DrugMass">
+      <Formula id="4opeT6MLU0yYrl1Z823qQw" name="DrugMass" dim="Amount" formula="DrugMass">
         <Paths>
           <Path path="15" as="5" dim="3" />
         </Paths>
diff --git a/src/Data/Templates/IV Bolus.pkml b/src/Data/Templates/IV Bolus.pkml
index adaf375bc..1f19c17b5 100644
--- a/src/Data/Templates/IV Bolus.pkml	
+++ b/src/Data/Templates/IV Bolus.pkml	
@@ -1,56 +1,56 @@
 <?xml version="1.0" encoding="utf-8"?>
-<EventGroupBuildingBlock id="_rv7unp96UaC2Ivqjp4ubw" name="IV Bolus" icon="EventGroup" bbVersion="0" version="13">
-  <Creation createdAt="5248308555518992012" createdBy="EZZJY" creationMode="New" origin="PKSim" version="7.3.0" internalVersion="74" />
+<EventGroupBuildingBlock id="EmoelXI34EOJnk8gyuXDZw" name="IV Bolus" icon="EventGroup" bbVersion="0" version="14">
+  <Creation createdAt="5248852327625273807" createdBy="Michael" creationMode="New" origin="PKSim" version="9.0" internalVersion="77" />
   <Builders>
-    <EventGroupBuilder id="W28LieFD6ku58QgQhF6RQA" name="Applications" icon="Applications" mode="Logical" containerType="EventGroup">
+    <EventGroupBuilder id="BP70S6uPIUyeGeGkhu-Z5w" name="Applications" icon="Applications" mode="Logical" containerType="EventGroup">
       <Children>
-        <EventGroupBuilder id="Yoaw-fqzS0eIgOTTqi5-7g" name="Protocol" mode="Logical" containerType="EventGroup">
+        <EventGroupBuilder id="Yb8GZfA-50qjmmdcs4af4g" name="Protocol" mode="Logical" containerType="EventGroup">
           <Children>
-            <ApplicationBuilder id="sekEHlM7-EyaPqKfnVXW1Q" name="Application_1" icon="IntravenousBolus" mode="Logical" containerType="Application" eventGroupType="IntravenousBolus" moleculeName="Standard Molecule">
+            <ApplicationBuilder id="T5hnQfTldUezgUVW3FIP2A" name="Application_1" icon="IntravenousBolus" mode="Logical" containerType="Application" eventGroupType="IntravenousBolus" moleculeName="Standard Molecule">
               <Tags>
                 <Tag value="Application" />
                 <Tag value="Application_1" />
                 <Tag value="ApplicationRoot" />
               </Tags>
               <Children>
-                <EventBuilder id="JXFzd-fgH0OuQcJk9zQREA" name="Application_StartEvent" oneTime="1" formula="WGhTwkuZ0U-VdfPj_MgjCA">
+                <EventBuilder id="erj7xQjoXUiSOVrhYZr7Zw" name="Application_StartEvent" oneTime="1" formula="DyU0aw347U67czctCandYw">
                   <Tags>
                     <Tag value="Application" />
                     <Tag value="Application_1" />
                   </Tags>
                   <Assignments>
-                    <EventAssignmentBuilder id="eywcuyQ4ZECejcPKD3TsWg" name="Assignment_1" useAsValue="1" dimension="Amount" formula="c_SE05e7FUeQA4edrrRr7A">
+                    <EventAssignmentBuilder id="_IOXG5rs60S85suCdETOlg" name="Assignment_1" useAsValue="1" dimension="Amount" formula="tDTyWb89VUeZNzODEkzRYQ">
                       <ObjectPath path="0" />
                     </EventAssignmentBuilder>
                   </Assignments>
                 </EventBuilder>
-                <Container id="RddyIr8Yk0mSTpTJnVfo9Q" name="ProtocolSchemaItem" mode="Logical" containerType="Other">
+                <Container id="ecub2Busq0WwCJXlwdgAng" name="ProtocolSchemaItem" mode="Logical" containerType="Other">
                   <Tags>
                     <Tag value="Application" />
                     <Tag value="Application_1" />
                   </Tags>
                   <Children>
-                    <Parameter id="g6heNbmwbU-vzgwdP1LNdg" name="Start time" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0" displayUnit="h">
+                    <Parameter id="fpxmVRz4l0-gcUlhvgvBYQ" name="Start time" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0" displayUnit="h">
                       <Info min="0" flag="58" seq="1" ref="0" bb="16" group="88" />
                     </Parameter>
-                    <Parameter id="HJErSn1840mgOBqJeOzu3Q" name="DrugMass" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" formula="jdedcn7BhkCEpsO2IeWJDw" isDefault="1" displayUnit="µmol">
-                      <Tags>
-                        <Tag value="MOLECULE" />
-                      </Tags>
-                      <Info min="0" flag="54" seq="2" ref="0" bb="2" group="88" />
+                    <Parameter id="0sgl3sCe1EO5MlOy7Xx3XQ" name="Dose" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="ApplicationParameter.PARAM_Application_DoseFromDosePerBodyWeight" isDefault="1" displayUnit="mg">
+                      <Info min="0" flag="50" seq="2" ref="0" bb="2" group="88" />
                     </Parameter>
-                    <Parameter id="CgDPD94V_UKa9_E4LS92Xg" name="DosePerBodySurfaceArea" icon="Parameter" persistable="0" isFixedValue="0" dim="Dose per body surface area" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0" displayUnit="mg/m²">
+                    <Parameter id="PxdlzJdOq0qWNL5ktHLy1w" name="DosePerBodySurfaceArea" icon="Parameter" persistable="0" isFixedValue="0" dim="Dose per body surface area" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0" displayUnit="mg/m²">
                       <Info min="0" flag="50" seq="2" ref="0" bb="2" group="88" />
                     </Parameter>
-                    <Parameter id="7GZt3L_CQkCXVySmYFaIbA" name="DosePerBodyWeight" icon="Parameter" persistable="0" isFixedValue="0" dim="Dose per body weight" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1E-06" displayUnit="mg/kg">
+                    <Parameter id="6MNPJV-MhEWZk00DAk9IrA" name="DosePerBodyWeight" icon="Parameter" persistable="0" isFixedValue="0" dim="Dose per body weight" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1E-06" displayUnit="mg/kg">
                       <Info min="0" flag="58" seq="2" ref="0" bb="16" group="88" />
                     </Parameter>
-                    <Parameter id="uXG2qJIo-0e0pVV2WgkvJw" name="Dose" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="ApplicationParameter.PARAM_Application_DoseFromDosePerBodyWeight" isDefault="1" displayUnit="mg">
-                      <Info min="0" flag="50" seq="2" ref="0" bb="2" group="88" />
+                    <Parameter id="3n6F0gtvvEmb6nuqfEN12Q" name="DrugMass" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" formula="EdHuCTmxrEuZIHFXY9GU1A" isDefault="1" displayUnit="µmol">
+                      <Tags>
+                        <Tag value="MOLECULE" />
+                      </Tags>
+                      <Info min="0" flag="54" seq="2" ref="0" bb="2" group="88" />
                     </Parameter>
                   </Children>
                 </Container>
-                <ApplicationMoleculeBuilder id="ixwfPol3zUKsTJmHaqsCmw" name="Application_1" formula="WvqvRAJR3UmhV7Hrw1xQTg">
+                <ApplicationMoleculeBuilder id="EIM8QD-MkEee3GuJFtaXJw" name="Application_1" formula="_S0kM_0aqEW1g96APACtBA">
                   <RelativeContainerPath path="1" />
                 </ApplicationMoleculeBuilder>
               </Children>
@@ -73,19 +73,19 @@
   </Builders>
   <FormulaCache>
     <Formulas>
-      <Formula id="c_SE05e7FUeQA4edrrRr7A" name="IV_Bolus" dim="Amount" formula="M + DrugMass">
+      <Formula id="tDTyWb89VUeZNzODEkzRYQ" name="IV_Bolus" dim="Amount" formula="M + DrugMass">
         <Paths>
           <Path path="0" as="2" dim="3" />
           <Path path="4" as="5" dim="3" />
         </Paths>
       </Formula>
-      <Formula id="WGhTwkuZ0U-VdfPj_MgjCA" name="AppStartEventCondition" formula="Time=StartTime">
+      <Formula id="DyU0aw347U67czctCandYw" name="AppStartEventCondition" formula="Time=StartTime">
         <Paths>
           <Path path="6" as="7" dim="8" />
           <TimePath />
         </Paths>
       </Formula>
-      <Formula id="jdedcn7BhkCEpsO2IeWJDw" name="PARAM_Application_DrugMass" dim="Amount" formula="Dose / MW">
+      <Formula id="EdHuCTmxrEuZIHFXY9GU1A" name="PARAM_Application_DrugMass" dim="Amount" formula="Dose / MW">
         <Paths>
           <Path path="9" as="10" dim="11" />
           <Path path="12" as="13" dim="14" />
@@ -97,7 +97,7 @@
           <Path path="18" as="19" dim="11" />
         </Paths>
       </Formula>
-      <Formula id="WvqvRAJR3UmhV7Hrw1xQTg" name="DrugMass" dim="Amount" formula="DrugMass">
+      <Formula id="_S0kM_0aqEW1g96APACtBA" name="DrugMass" dim="Amount" formula="DrugMass">
         <Paths>
           <Path path="20" as="5" dim="3" />
         </Paths>
diff --git a/src/Data/Templates/Standard Molecule.pkml b/src/Data/Templates/Standard Molecule.pkml
index cadd90063..a10abadb2 100644
--- a/src/Data/Templates/Standard Molecule.pkml	
+++ b/src/Data/Templates/Standard Molecule.pkml	
@@ -1,286 +1,289 @@
 <?xml version="1.0" encoding="utf-8"?>
-<MoleculeBuildingBlock id="Fqc58kb4ZUSPv7Hj5oc_5A" name="Standard Molecule" icon="Molecule" bbVersion="0" version="13">
-  <Creation createdAt="5248308555518932009" createdBy="EZZJY" creationMode="New" origin="PKSim" version="7.3.0" internalVersion="74" />
+<MoleculeBuildingBlock id="XqIhKGR9cU6fzSgQbgAXhA" name="Standard Molecule" icon="Molecule" bbVersion="0" version="14">
+  <Creation createdAt="5248852327625174075" createdBy="Michael" creationMode="New" origin="PKSim" version="9.0" internalVersion="77" />
   <Builders>
-    <MoleculeBuilder id="DxeT_qiyS0awdthRfvAhYg" icon="DRUG" mode="Logical" containerType="Other" isFloating="1" quantityType="Drug" isXenobiotic="1" dim="Amount" defaultStartFormula="JLo_YprpNUuVcfA4Kx4Ivg" displayUnit="µmol">
+    <MoleculeBuilder id="sB22fzhI30-W-AJ4_ktxIQ" icon="DRUG" mode="Logical" containerType="Other" isFloating="1" quantityType="Drug" isXenobiotic="1" dim="Amount" defaultStartFormula="6_J3J9oQ1Ealjl77qIqeJA" displayUnit="µmol">
       <Children>
-        <Parameter id="aLx9DxfP_UqjaT7qBEbkVA" name="pKa_TwoAcids_1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_TwoAcids_1" buildMode="Property" isDefault="1">
-          <Info min="0" max="14" flag="52" seq="1" ref="0" bb="4" group="16" />
-        </Parameter>
-        <Parameter id="5xOChceEWEKo89DBn9aXAw" name="Total drug mass" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_TotalDrugMass" buildMode="Property" isDefault="1" displayUnit="µmol">
-          <Info min="0" flag="52" seq="1" ref="0" bb="2" group="9" />
+        <Parameter id="zgscS4laxkuZzTo1Yhjgeg" name="base_For_KaPL_Factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="20">
+          <ValueOrigin id="34" source="Publication" description="Toxicol In Vitro. 2008 Mar;22(2):457-67 https://doi.org/10.1016/j.tiv.2007.09.010" />
+          <Info min="0" flag="36" seq="1" ref="0" bb="4" group="16" />
         </Parameter>
-        <Parameter id="r-OBUscj7U-W80GQKXB84g" name="pKa_TwoBases_1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_TwoBases_1" buildMode="Property" isDefault="1">
-          <Info min="0" max="14" flag="52" seq="1" ref="0" bb="4" group="16" />
+        <Parameter id="UnbSvYG-NUGRsL3fIkUt9g" name="base_For_logD_Factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0.001">
+          <ValueOrigin id="34" source="Publication" description="Toxicol In Vitro. 2008 Mar;22(2):457-67 https://doi.org/10.1016/j.tiv.2007.09.010" />
+          <Info min="0" flag="36" seq="1" ref="0" bb="4" group="16" />
         </Parameter>
-        <Parameter id="Lfo7i38k2U-IfWSQxJcNvg" name="Plasma protein binding partner" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="0" value="2">
-          <Info flag="58" seq="1" ref="0" bb="4" group="9" />
+        <Parameter id="C3yQiFuW7EmIzz4BlvWnCA" name="base_For_P_cell_Factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0.001">
+          <Info min="0" flag="36" seq="1" ref="0" bb="4" group="16" />
         </Parameter>
-        <Parameter id="yGSIP95E2UaFV0IxzH7mGQ" name="Total oral drug mass" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0" displayUnit="µmol">
-          <Info min="0" flag="52" seq="1" ref="0" bb="2" group="63" />
+        <Parameter id="iCgEkNkOWkStr7qBg4dDXA" name="base_For_Pint_Factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0.1">
+          <Info min="0" flag="36" seq="1" ref="0" bb="4" group="16" />
         </Parameter>
-        <Parameter id="86e5qmLsg0iJgTSVCDqxBQ" name="Solubility_pKa_pH_Factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_RefpH_Factor" buildMode="Property" isDefault="1">
-          <Info min="0" flag="52" seq="1" ref="0" bb="4" group="18" />
+        <Parameter id="a1j63PTpXkacTX7ROA2xUg" name="BP_AGP" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0">
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         </Parameter>
-        <Parameter id="6cgR6PVrX0K7lFvGMomnMg" name="pKa_Bases_Count" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_Bases_Count" buildMode="Property" isDefault="1">
+        <Parameter id="l1PqxWrW-E2q-RNGhFnrAg" name="pKa_Base_1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_Base_1" buildMode="Property" isDefault="1">
+          <Info min="0" max="14" flag="52" seq="1" ref="0" bb="4" group="16" />
+        </Parameter>
+        <Parameter id="JgftrniTYEiwyc43CEmWxw" name="pKa_Base_2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_Base_2" buildMode="Property" isDefault="1">
+          <Info min="0" max="14" flag="52" seq="1" ref="0" bb="4" group="16" />
+        </Parameter>
+        <Parameter id="IiqhWpF130GMCLsklyuXcA" name="pKa_Bases_Count" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_Bases_Count" buildMode="Property" isDefault="1">
           <Info min="0" max="3" flag="52" seq="1" ref="0" bb="4" group="16" />
         </Parameter>
-        <Parameter id="h_EN0tDe80SJbyRHNhjJGA" name="pKa_OneAcid_0" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_OneAcid_0" buildMode="Property" isDefault="1">
+        <Parameter id="vnbkDsIqqk2U1b0XBEVApA" name="pKa_OneAcid_0" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_OneAcid_0" buildMode="Property" isDefault="1">
           <Info min="0" max="14" flag="52" seq="1" ref="0" bb="4" group="16" />
         </Parameter>
-        <Parameter id="hKMQoTvz6E6mgSx9HLG-XA" name="pKa_OneBase_0" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_OneBase_0" buildMode="Property" isDefault="1">
+        <Parameter id="Rx4dGaiNr0u16DyNjuUwMQ" name="pKa_OneBase_0" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_OneBase_0" buildMode="Property" isDefault="1">
           <Info min="0" max="14" flag="52" seq="1" ref="0" bb="4" group="16" />
         </Parameter>
-        <Parameter id="YfwZyHuSGk-ciuvIxocCIg" name="pKa_pH_WS_sol_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_F1" buildMode="Property" isDefault="1">
+        <Parameter id="4-01hYNHOUy96ADASRC8pQ" name="pKa_pH_WS_sol_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_F1" buildMode="Property" isDefault="1">
           <Info min="0" max="1" flag="52" seq="1" ref="0" bb="4" group="18" />
         </Parameter>
-        <Parameter id="Hnay04rHR0icCerILcvw7w" name="pKa_pH_WS_sol_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_F2" buildMode="Property" isDefault="1">
+        <Parameter id="WCuWRVibik2N4Zj73VH88w" name="pKa_pH_WS_sol_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_F2" buildMode="Property" isDefault="1">
           <Info min="0" max="1" flag="52" seq="1" ref="0" bb="4" group="18" />
         </Parameter>
-        <Parameter id="-Ub_F3aTHEmd55GWQZNX1A" name="pKa_pH_WS_sol_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_F3" buildMode="Property" isDefault="1">
+        <Parameter id="F3AwiVkzF0mQjl0250LfGA" name="pKa_pH_WS_sol_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_F3" buildMode="Property" isDefault="1">
           <Info min="0" max="1" flag="52" seq="1" ref="0" bb="4" group="18" />
         </Parameter>
-        <Parameter id="wn6exNZ8c0CcOWFnde46Qw" name="pKa_Base_0" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_Base_0" buildMode="Property" isDefault="1">
-          <Info min="0" max="14" flag="52" seq="1" ref="0" bb="4" group="16" />
+        <Parameter id="zidJXZKZsU2VEinlDJNeow" name="pKa_pH_WS_sol_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_K1" buildMode="Property" isDefault="1">
+          <Info min="0" max="1" flag="52" seq="1" ref="0" bb="4" group="18" />
         </Parameter>
-        <Parameter id="Sshl7ydbrUGFyAS5QDlNqA" name="pKa_pH_WS_sol_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_K2" buildMode="Property" isDefault="1">
+        <Parameter id="EKTbi1_FeEKEr0byl6NAvQ" name="pKa_pH_WS_sol_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_K2" buildMode="Property" isDefault="1">
           <Info min="0" max="1" flag="52" seq="1" ref="0" bb="4" group="18" />
         </Parameter>
-        <Parameter id="kUyfShKDR0e5UZg7NbVubQ" name="pKa_Acids_Count" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_Acids_Count" buildMode="Property" isDefault="1">
-          <Info min="0" max="3" flag="52" seq="1" ref="0" bb="4" group="16" />
+        <Parameter id="_SdwBJ37SEWsti6eb9yD9Q" name="pKa_pH_WS_sol_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_K3" buildMode="Property" isDefault="1">
+          <Info min="0" max="1" flag="52" seq="1" ref="0" bb="4" group="18" />
         </Parameter>
-        <Parameter id="xHCrFidxP0Gx-GD9O3HH-w" name="pKa_pH_WS_sol_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_K4" buildMode="Property" isDefault="1">
+        <Parameter id="_CKq5bCsYUCMD6OZ63uQlQ" name="pKa_pH_WS_sol_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_K4" buildMode="Property" isDefault="1">
           <Info min="0" max="1" flag="52" seq="1" ref="0" bb="4" group="18" />
         </Parameter>
-        <Parameter id="DRDZ2ifdc0e3wDU487Xwyw" name="pKa_pH_WS_sol_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_K5" buildMode="Property" isDefault="1">
+        <Parameter id="uqkVPiYa70qupM1GhCmELA" name="pKa_pH_WS_sol_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_K5" buildMode="Property" isDefault="1">
           <Info min="0" max="1" flag="52" seq="1" ref="0" bb="4" group="18" />
         </Parameter>
-        <Parameter id="CGil9mVZiUqNjQb93bOJoA" name="pKa_pH_WS_sol_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_K6" buildMode="Property" isDefault="1">
+        <Parameter id="eFKB0x-r7kW0Z1FdiVpxlg" name="pKa_pH_WS_sol_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_K6" buildMode="Property" isDefault="1">
           <Info min="0" max="1" flag="52" seq="1" ref="0" bb="4" group="18" />
         </Parameter>
-        <Parameter id="XHLpuwOh1EGaeuYrjO9mew" name="pKa_pH_WS_sol_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_K7" buildMode="Property" isDefault="1">
+        <Parameter id="2lFPcD2IaUWpnHqX2YHjlg" name="pKa_pH_WS_sol_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_K7" buildMode="Property" isDefault="1">
           <Info min="0" max="1" flag="52" seq="1" ref="0" bb="4" group="18" />
         </Parameter>
-        <Parameter id="hw2H8OLhikSR7zaYKK8gXQ" name="pKa_pH_WS_sol_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_K8" buildMode="Property" isDefault="1">
+        <Parameter id="PCcfj7ESTke-aW_ZNtJaRA" name="pKa_pH_WS_sol_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_K8" buildMode="Property" isDefault="1">
           <Info min="0" max="1" flag="52" seq="1" ref="0" bb="4" group="18" />
         </Parameter>
-        <Parameter id="JAN2i2vyrkqzKdGDAY_zYA" name="pKa_ThreeAcids_0" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_ThreeAcids_0" buildMode="Property" isDefault="1">
+        <Parameter id="zwTdRVXoYUKsvOebg-hxrg" name="pKa_ThreeAcids_0" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_ThreeAcids_0" buildMode="Property" isDefault="1">
           <Info min="0" max="14" flag="52" seq="1" ref="0" bb="4" group="16" />
         </Parameter>
-        <Parameter id="HY_UPmFW3E6dwsMKDLOhkg" name="pKa_ThreeAcids_1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_ThreeAcids_1" buildMode="Property" isDefault="1">
+        <Parameter id="5gt5VEM-nEuxl1CHzc2f5A" name="pKa_ThreeAcids_1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_ThreeAcids_1" buildMode="Property" isDefault="1">
           <Info min="0" max="14" flag="52" seq="1" ref="0" bb="4" group="16" />
         </Parameter>
-        <Parameter id="O2uD_Lrv50-LpyHhLCzacA" name="pKa_ThreeBases_0" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_ThreeBases_0" buildMode="Property" isDefault="1">
+        <Parameter id="SCnkOkeSeUCctu2idZrDJA" name="pKa_ThreeBases_0" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_ThreeBases_0" buildMode="Property" isDefault="1">
           <Info min="0" max="14" flag="52" seq="1" ref="0" bb="4" group="16" />
         </Parameter>
-        <Parameter id="ByZlJORkzU6eX4fniIuSog" name="pKa_ThreeBases_1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_ThreeBases_1" buildMode="Property" isDefault="1">
+        <Parameter id="34QqeAppZEKzoi8XOOn15Q" name="pKa_ThreeBases_1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_ThreeBases_1" buildMode="Property" isDefault="1">
           <Info min="0" max="14" flag="52" seq="1" ref="0" bb="4" group="16" />
         </Parameter>
-        <Parameter id="kxoSYETwkU6LehGTXnEHMg" name="pKa_pH_WS_sol_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_K1" buildMode="Property" isDefault="1">
-          <Info min="0" max="1" flag="52" seq="1" ref="0" bb="4" group="18" />
-        </Parameter>
-        <Parameter id="e-YeuBKli0G5b9hmHpOvLQ" name="Is monoprotic base diprotic acid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_IsMonoproticBaseDiproticAcid" buildMode="Property" isDefault="1">
-          <Info min="0" max="1" flag="52" seq="1" ref="0" bb="4" group="16" />
-        </Parameter>
-        <Parameter id="rWdFHDl680m2U-dkT4edSw" name="Is monoprotic base monoprotic acid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_IsMonoproticBaseMonoproticAcid" buildMode="Property" isDefault="1">
-          <Info min="0" max="1" flag="52" seq="1" ref="0" bb="4" group="16" />
-        </Parameter>
-        <Parameter id="JTn6TK2i3kGoqOdkgl3d-A" name="Is neutral" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_IsNeutral" buildMode="Property" isDefault="1">
-          <Info min="0" flag="52" seq="1" ref="0" bb="4" group="16" />
-        </Parameter>
-        <Parameter id="MR8D6NuMJEGFOipWPK7kbA" name="Is small molecule" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="0" value="1">
-          <Info min="0" max="1" flag="60" seq="1" ref="0" bb="4" group="9" />
-        </Parameter>
-        <Parameter id="ZHgtsBqIx0KS9NvW3VQVmA" name="Is strong base" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_HasStrongBase" buildMode="Property" isDefault="1">
-          <Info min="0" flag="52" seq="1" ref="0" bb="4" group="16" />
-        </Parameter>
-        <Parameter id="UCo2IstBpUWT_tUh50zhsg" name="Is triprotic acid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_IsTriproticAcid" buildMode="Property" isDefault="1">
-          <Info min="0" max="1" flag="52" seq="1" ref="0" bb="4" group="16" />
-        </Parameter>
-        <Parameter id="0iES3iuwjUGj3PGK8vnhVA" name="Is triprotic base" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_IsTriproticBase" buildMode="Property" isDefault="1">
-          <Info min="0" max="1" flag="52" seq="1" ref="0" bb="4" group="16" />
-        </Parameter>
-        <Parameter id="kYhEIdef7kecH-0euldCJg" name="pKa_Base_1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_Base_1" buildMode="Property" isDefault="1">
+        <Parameter id="elg860Uh7EifUDfyBxda8A" name="pKa_TwoAcids_0" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_TwoAcids_0" buildMode="Property" isDefault="1">
           <Info min="0" max="14" flag="52" seq="1" ref="0" bb="4" group="16" />
         </Parameter>
-        <Parameter id="3IpQ2Z8SX0akKO9L34RKyA" name="Molecular weight" icon="Parameter" persistable="0" isFixedValue="0" dim="Molecular weight" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="0" value="NaN" displayUnit="g/mol">
-          <Info min="1.5E-08" flag="56" seq="1" ref="0" bb="4" group="13" />
+        <Parameter id="dXDaiqg4MkqdFW0lbj1SlA" name="pKa_TwoAcids_1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_TwoAcids_1" buildMode="Property" isDefault="1">
+          <Info min="0" max="14" flag="52" seq="1" ref="0" bb="4" group="16" />
         </Parameter>
-        <Parameter id="nEgqwOkyi0q4B4W0t2YAZA" name="pKa value 0" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0">
-          <Info min="0" max="14" flag="58" seq="1" ref="0" bb="4" group="16" />
+        <Parameter id="4Lm1_pAVdkedIGQN0CrcMg" name="pKa_TwoBases_0" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_TwoBases_0" buildMode="Property" isDefault="1">
+          <Info min="0" max="14" flag="52" seq="1" ref="0" bb="4" group="16" />
         </Parameter>
-        <Parameter id="G1CcB3RgCk2JRloOMmo4WQ" name="pKa value 1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0">
-          <Info min="0" max="14" flag="58" seq="1" ref="0" bb="4" group="16" />
+        <Parameter id="8eCUu--Nm0eIFjp_j-Oyxw" name="pKa_TwoBases_1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_TwoBases_1" buildMode="Property" isDefault="1">
+          <Info min="0" max="14" flag="52" seq="1" ref="0" bb="4" group="16" />
         </Parameter>
-        <Parameter id="Dp7sLhcogEO7DPO4_1NK-Q" name="pKa value 2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0">
-          <Info min="0" max="14" flag="58" seq="1" ref="0" bb="4" group="16" />
+        <Parameter id="or7dHSu2pkiXuQaaSs8hxg" name="Plasma protein binding partner" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="0" value="2">
+          <Info flag="58" seq="1" ref="0" bb="4" group="9" />
         </Parameter>
-        <Parameter id="c_u9t_IlB02PVX3wZ-kjaA" name="pKa_Acid_0" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_Acid_0" buildMode="Property" isDefault="1">
-          <Info min="0" max="14" flag="52" seq="1" ref="0" bb="4" group="16" />
+        <Parameter id="hxnbXyIpZUaznqTI7JvNnQ" name="Solubility_pKa_pH_Factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_RefpH_Factor" buildMode="Property" isDefault="1">
+          <Info min="0" flag="52" seq="1" ref="0" bb="4" group="18" />
         </Parameter>
-        <Parameter id="ws2oykKbbkWXVGcM-vtiYg" name="pKa_Acid_1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_Acid_1" buildMode="Property" isDefault="1">
-          <Info min="0" max="14" flag="52" seq="1" ref="0" bb="4" group="16" />
+        <Parameter id="bfn2-53dREegQkBrMsv7WA" name="Total drug mass" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" formula="DynamicSumFormulas.PARAM_TotalDrugMass" buildMode="Property" isDefault="1" displayUnit="µmol">
+          <Info min="0" flag="52" seq="1" ref="0" bb="2" group="9" />
         </Parameter>
-        <Parameter id="xDuOPSA41k6QO9CVCeyGRg" name="pKa_Acid_2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundAcidBase_PKSim.PARAM_pKa_Acid_2" buildMode="Property" isDefault="1">
-          <Info min="0" max="14" flag="52" seq="1" ref="0" bb="4" group="16" />
+        <Parameter id="GZX9A2p1akyr-0RUWoBpAw" name="Total oral drug mass" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0" displayUnit="µmol">
+          <Info min="0" flag="52" seq="1" ref="0" bb="2" group="63" />
         </Parameter>
-        <Parameter id="6gekga_RE0-8KRqbwGJkjA" name="Lipophilicity" icon="Parameter" persistable="0" isFixedValue="0" dim="Log Units" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="0" value="NaN" displayUnit="Log Units">
+        <Parameter id="yz76RCxBEUqRbePDWT5ajg" name="Lipophilicity" icon="Parameter" persistable="0" isFixedValue="0" dim="Log Units" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="0" value="NaN" displayUnit="Log Units">
           <Info min="-10" max="10" flag="58" seq="2" ref="0" bb="4" group="12" />
         </Parameter>
-        <Parameter id="OIjl-UkitUqWQ5GUNsOJ-Q" name="Fraction unbound (plasma, reference value)" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="0" value="NaN">
+        <Parameter id="I0NLkJQC80mdJnQNGWajng" name="Fraction unbound (plasma, reference value)" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="0" value="NaN">
           <Info min="0" max="1" flag="106" seq="3" ref="0" bb="4" group="10" />
         </Parameter>
-        <Parameter id="e63HJTLONUyy8wxunSqBrQ" name="Solubility at reference pH" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="0" value="NaN" displayUnit="mg/l">
+        <Parameter id="lHTg5-Nd7EWOM5cI-8fEqg" name="Solubility at reference pH" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="0" value="NaN" displayUnit="mg/l">
           <Info min="0" flag="122" seq="4" ref="0" bb="4" group="18" />
         </Parameter>
-        <Parameter id="QGg7JqXEkkmJ3-58Wcy-Tw" name="Solubility table" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0" displayUnit="mg/l">
+        <Parameter id="bP86AtpLO06buJTcbuf47g" name="Solubility table" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0" displayUnit="mg/l">
           <Info min="0" flag="48" seq="4" ref="0" bb="4" group="18" />
         </Parameter>
-        <Parameter id="8hnSj9J0wU6XXFChCiPqgg" name="Reference pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="0" value="7">
+        <Parameter id="-rBeeuh7LkS5cHBCjFhpTA" name="Reference pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="0" value="7">
           <Info min="0" max="14" flag="58" seq="5" ref="0" bb="4" group="18" />
         </Parameter>
-        <Parameter id="FD9pw9nHJEyi1MsR3w1nSg" name="Solubility gain per charge" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="1000">
+        <Parameter id="Z8s8N-p4LkueF1W7R_6NHA" name="Solubility gain per charge" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="1000">
           <Info min="0" flag="42" seq="6" ref="0" bb="4" group="18" />
         </Parameter>
-        <Parameter id="2ISNtF9GGUaKCp1JZsaJ2g" name="Permeability" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P" buildMode="Property" isDefault="1" displayUnit="cm/min">
+        <Parameter id="OiKMYOxFfEy1IZ1-br3sJQ" name="Permeability" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="DiffusionCommon_PKSim.PARAM_P" buildMode="Property" isDefault="1" displayUnit="cm/min">
           <Info min="0" flag="62" seq="7" ref="0" bb="4" group="15" />
         </Parameter>
-        <Parameter id="GE5EWmfzhkC3PRzy4wyJOw" name="Specific intestinal permeability (transcellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_InVitro" buildMode="Property" isDefault="1" displayUnit="cm/min">
+        <Parameter id="WHe2EnUmI0a9cK7BPJMOyw" name="Specific intestinal permeability (transcellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_InVitro" buildMode="Property" isDefault="1" displayUnit="cm/min">
           <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
           <Info min="0" flag="62" seq="8" ref="0" bb="4" group="11" />
         </Parameter>
-        <Parameter id="BKIJuy4mBECsYXnnGLUn0A" name="Partition coefficient (water/protein)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionInVitro_PKSim.PARAM_KProt" buildMode="Global" isDefault="1">
-          <Info min="0" flag="58" seq="9" ref="0" bb="2" group="67" />
+        <Parameter id="qjlkdQeQsE6aScWEM5TkZQ" name="Partition coefficient (water/protein)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DistributionInVitro_PKSim.PARAM_KProt" buildMode="Global" isDefault="1">
+          <Info min="0" flag="122" seq="9" ref="0" bb="2" group="67" />
         </Parameter>
-        <Parameter id="ZZ5bbdo0v02xHrBNMhVeLQ" name="Treat precipitated drug as" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="1">
+        <Parameter id="Fvm4Bcxha0KsrjKNl0cF6g" name="Treat precipitated drug as" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="1">
           <Info min="0" max="1" flag="58" seq="30" ref="0" bb="4" group="14" />
         </Parameter>
-        <Parameter id="QUO9hXH5fUWxKkIBD0AbjQ" name="Aqueous diffusion coefficient" icon="Parameter" persistable="0" isFixedValue="0" dim="Diffusion coefficient" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_Aqueous_diffusion_coefficient" buildMode="Property" isDefault="1" displayUnit="cm²/min">
+        <Parameter id="TQmKgxiIr0SEYrTYR2I7qA" name="Aqueous diffusion coefficient" icon="Parameter" persistable="0" isFixedValue="0" dim="Diffusion coefficient" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_Aqueous_diffusion_coefficient" buildMode="Property" isDefault="1" displayUnit="cm²/min">
           <ValueOrigin id="32" source="Publication" description="Willmann S, Thelen K, Becker C, et al. Mechanism-based prediction of particle size-dependent dissolution and absorption: cilostazol pharmacokinetics in dogs. Eur J Pharm Biopharm. 2010 Sep;76(1):83-94 https://doi.org/10.1016/j.ejpb.2010.06.003" />
           <Info min="6E-13" max="0.6" flag="58" seq="31" ref="0" bb="4" group="14" />
         </Parameter>
-        <Parameter id="8L2U4qrzuESEEy5Hi2_LlQ" name="Density (drug)" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="1" displayUnit="g/cm³">
+        <Parameter id="m66qh5Q8DEOAZMz67eA1Lw" name="Density (drug)" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="1" displayUnit="g/cm³">
           <ValueOrigin id="32" source="Publication" description="Willmann S, Thelen K, Becker C, et al. Mechanism-based prediction of particle size-dependent dissolution and absorption: cilostazol pharmacokinetics in dogs. Eur J Pharm Biopharm. 2010 Sep;76(1):83-94 https://doi.org/10.1016/j.ejpb.2010.06.003" />
           <Info min="2.5E-06" flag="58" seq="32" ref="0" bb="4" group="14" />
         </Parameter>
-        <Parameter id="aaEX1jEA10WCW_Zxhlpnuw" name="Immediately dissolve particles smaller than" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="1E-07" displayUnit="µm">
+        <Parameter id="y30OSvzdDkKAW35JmsUvkA" name="Immediately dissolve particles smaller than" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="1E-07" displayUnit="µm">
           <ValueOrigin id="32" source="Publication" description="Willmann S, Thelen K, Becker C, et al. Mechanism-based prediction of particle size-dependent dissolution and absorption: cilostazol pharmacokinetics in dogs. Eur J Pharm Biopharm. 2010 Sep;76(1):83-94 https://doi.org/10.1016/j.ejpb.2010.06.003" />
           <Info min="1E-35" flag="58" seq="33" ref="0" bb="4" group="14" />
         </Parameter>
-        <Parameter id="NVL27GVuU0mdnSzUZJljIg" name="Radius (solute)" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_Ae" buildMode="Property" isDefault="1" displayUnit="µm">
+        <Parameter id="mH-4kflR4U2lwAhoi6NldA" name="Radius (solute)" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="CompoundCommon.PARAM_Ae" buildMode="Property" isDefault="1" displayUnit="µm">
           <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
           <Info min="0" flag="58" seq="40" ref="0" bb="4" group="19" />
         </Parameter>
-        <Parameter id="wr0QSSCwKk2I2vjyM5wCsw" name="Kd (FcRn) in endosomal space" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="999999" displayUnit="µmol/l">
+        <Parameter id="8Ii50FDCiUqV075vnJZ9MA" name="Kd (FcRn) in endosomal space" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="999999" displayUnit="µmol/l">
           <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
           <Info min="0" flag="58" seq="41" ref="0" bb="4" group="19" />
         </Parameter>
-        <Parameter id="VHV-Fov-40yvQwgh2Ys4zg" name="Kd (FcRn) in plasma/interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="999999" displayUnit="µmol/l">
+        <Parameter id="5MTBSsXJsEiUWM8ZPJsvZQ" name="Kd (FcRn) in plasma/interstitial" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="999999" displayUnit="µmol/l">
           <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
           <Info min="0" flag="58" seq="42" ref="0" bb="4" group="19" />
         </Parameter>
-        <Parameter id="blaT3jazsUe836qL3ylQww" name="kass (FcRn)" icon="Parameter" persistable="0" isFixedValue="0" dim="Second order rate constant" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0.87" displayUnit="l/µmol/min">
+        <Parameter id="7vR9MAYm30if_YpuZoJm2A" name="kass (FcRn)" icon="Parameter" persistable="0" isFixedValue="0" dim="Second order rate constant" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0.87" displayUnit="l/µmol/min">
           <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
           <Info min="0" flag="58" seq="43" ref="0" bb="4" group="19" />
         </Parameter>
-        <Parameter id="UHzTzJIF6EKI_KPXDN6-JQ" name="Use pH- and pKa-dependent penalty factor for charged molecule fraction" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Global" isDefault="1" value="0">
+        <Parameter id="r2IgZmhGxE2_a4QXKjuQkg" name="Use pH- and pKa-dependent penalty factor for charged molecule fraction" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Global" isDefault="1" value="0">
           <Info min="0" max="1" flag="58" seq="100" ref="0" bb="2" group="75" />
         </Parameter>
-        <Parameter id="e6sv1Tz8jkqhkkoAMGQqHw" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="ConcFormula" isDefault="1">
+        <Parameter id="on-hP71YFku7eVZPwvhfRg" name="Enable supersaturation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0">
+          <Info min="0" max="1" flag="58" seq="100" ref="0" bb="4" group="14" />
+        </Parameter>
+        <Parameter id="6WFsUI1DbUe2XYDZppkLcA" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="ConcFormula" isDefault="1" displayUnit="µmol/l">
           <Info min="0" flag="18" seq="1" ref="0" bb="2" group="117" />
         </Parameter>
       </Children>
@@ -294,385 +297,385 @@
   </Builders>
   <FormulaCache>
     <Formulas>
-      <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_TwoAcids_1" name="PARAM_pKa_TwoAcids_1" formula="pKa_Acids_Count=2 ? (CT0 != CT_ACID ? Max(pKa_1;pKa_2) : (CT1 != CT_ACID ? Max(pKa_0;pKa_2) : Max(pKa_0;pKa_1))) : 0">
+      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_InVitro" name="PARAM_P_int_InVitro" dim="Velocity" formula="IsSmallMolecule ? 266 * (MWEff * 1E9) ^ ( - 4.5) * 10^LogMA * 60 *1E-1 : 0">
+        <Paths>
+          <Path path="0" as="1" dim="2" />
+          <Path path="3" as="4" />
+          <Path path="5" as="6" dim="7" />
+        </Paths>
+      </Formula>
+      <Formula id="CompoundMW_PKSim.PARAM_MWEff" name="PARAM_MWEff" dim="Molecular weight" formula="MW - F * 0.000000017 - Cl * 0.000000022 - Br * 0.000000062 - I * 0.000000098">
         <Paths>
-          <Path path="0" as="1" />
-          <Path path="2" as="3" />
-          <Path path="4" as="5" />
-          <Path path="6" as="7" />
           <Path path="8" as="9" />
           <Path path="10" as="11" />
           <Path path="12" as="13" />
+          <Path path="14" as="15" />
+          <Path path="16" as="17" dim="2" />
         </Paths>
       </Formula>
-      <SumFormula id="DynamicSumFormulas.PARAM_TotalDrugMass" name="PARAM_TotalDrugMass" dim="Amount" variable="P" formulaString="P_#i">
-        <Criteria>
-          <DescriptorConditions>
-            <MatchTagCondition tag="DrugMass" />
-            <MatchTagCondition tag="MOLECULE" />
-          </DescriptorConditions>
-        </Criteria>
-      </SumFormula>
-      <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_TwoBases_1" name="PARAM_pKa_TwoBases_1" formula="pKa_Bases_Count=2 ? (CT0 != CT_BASE ? Max(pKa_1;pKa_2) : (CT1 != CT_BASE ? Max(pKa_0;pKa_2) : Max(pKa_0;pKa_1))) : 0">
+      <Formula id="CompoundMW_PKSim.PARAM_HasHalogens" name="PARAM_HasHalogens" formula="Br + Chlor + F + I &gt; 0">
         <Paths>
-          <Path path="0" as="1" />
-          <Path path="2" as="3" />
-          <Path path="14" as="15" />
-          <Path path="6" as="7" />
           <Path path="8" as="9" />
-          <Path path="10" as="11" />
-          <Path path="16" as="17" />
+          <Path path="10" as="18" />
+          <Path path="12" as="13" />
+          <Path path="14" as="15" />
         </Paths>
       </Formula>
-      <Formula id="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_RefpH_Factor" name="PARAM_Solubility_pKa_RefpH_Factor" formula="K1+K2/base^(CT0^2)+K3/base^(CT1^2)+K4/base^(CT2^2)+K5/base^max(CT0+CT1;-CT0-CT1)+K6/base^max(CT0+CT2;-CT0-CT2)+K7/base^max(CT1+CT2;-CT1-CT2)+K8/base^max(CT0+CT1+CT2;-CT0-CT1-CT2)">
+      <Formula id="CompoundAcidBase_PKSim.PARAM_IsDiproticAcid" name="PARAM_IsDiproticAcid" formula="pKa_Acids_Count=2 &amp; pKa_Bases_Count = 0 ? 1 : 0">
         <Paths>
-          <Path path="0" as="1" />
-          <Path path="2" as="3" />
-          <Path path="18" as="19" />
-          <Path path="20" as="21" />
-          <Path path="22" as="23" />
-          <Path path="24" as="25" />
-          <Path path="26" as="27" />
-          <Path path="28" as="29" />
-          <Path path="30" as="31" />
-          <Path path="32" as="33" />
-          <Path path="34" as="35" />
-          <Path path="36" as="37" />
+          <Path path="19" as="20" />
+          <Path path="21" as="22" />
         </Paths>
       </Formula>
-      <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_TwoAcids_0" name="PARAM_pKa_TwoAcids_0" formula="pKa_Acids_Count=2 ? (CT0 != CT_ACID ? Min(pKa_1;pKa_2) : (CT1 != CT_ACID ? Min(pKa_0;pKa_2) : Min(pKa_0;pKa_1))) : 0">
+      <Formula id="CompoundAcidBase_PKSim.PARAM_IsDiproticBase" name="PARAM_IsDiproticBase" formula="pKa_Acids_Count=0 &amp; pKa_Bases_Count = 2 ? 1 : 0">
         <Paths>
-          <Path path="0" as="1" />
-          <Path path="2" as="3" />
-          <Path path="4" as="5" />
-          <Path path="6" as="7" />
-          <Path path="8" as="9" />
-          <Path path="10" as="11" />
-          <Path path="12" as="13" />
+          <Path path="19" as="20" />
+          <Path path="21" as="22" />
         </Paths>
       </Formula>
-      <Formula id="CompoundMW_PKSim.PARAM_MWEff" name="PARAM_MWEff" dim="Molecular weight" formula="MW - F * 0.000000017 - Cl * 0.000000022 - Br * 0.000000062 - I * 0.000000098">
+      <Formula id="CompoundAcidBase_PKSim.PARAM_IsDiproticBaseMonoproticAcid" name="PARAM_IsDiproticBaseMonoproticAcid" formula="pKa_Acids_Count=1 &amp; pKa_Bases_Count = 2 ? 1 : 0">
         <Paths>
-          <Path path="38" as="39" />
-          <Path path="40" as="41" />
-          <Path path="42" as="43" />
-          <Path path="44" as="45" />
-          <Path path="46" as="47" dim="48" />
+          <Path path="19" as="20" />
+          <Path path="21" as="22" />
         </Paths>
       </Formula>
       <Formula id="CompoundAcidBase_PKSim.PARAM_IsMonoproticAcid" name="PARAM_IsMonoproticAcid" formula="pKa_Acids_Count=1 &amp; pKa_Bases_Count = 0 ? 1 : 0">
         <Paths>
-          <Path path="12" as="13" />
-          <Path path="16" as="17" />
+          <Path path="19" as="20" />
+          <Path path="21" as="22" />
         </Paths>
       </Formula>
-      <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_InVitro" name="PARAM_P_int_InVitro" dim="Velocity" formula="IsSmallMolecule ? 266 * (MWEff * 1E9) ^ ( - 4.5) * 10^LogMA * 60 *1E-1 : 0">
+      <Formula id="CompoundAcidBase_PKSim.PARAM_IsMonoproticBase" name="PARAM_IsMonoproticBase" formula="pKa_Acids_Count=0 &amp; pKa_Bases_Count = 1 ? 1 : 0">
         <Paths>
-          <Path path="49" as="50" dim="48" />
-          <Path path="51" as="52" />
-          <Path path="53" as="54" dim="55" />
+          <Path path="19" as="20" />
+          <Path path="21" as="22" />
         </Paths>
       </Formula>
-      <Formula id="CompoundMW_PKSim.PARAM_HasHalogens" name="PARAM_HasHalogens" formula="Br + Chlor + F + I &gt; 0">
+      <Formula id="CompoundAcidBase_PKSim.PARAM_IsMonoproticBaseDiproticAcid" name="PARAM_IsMonoproticBaseDiproticAcid" formula="pKa_Acids_Count=2 &amp; pKa_Bases_Count = 1 ? 1 : 0">
         <Paths>
-          <Path path="38" as="39" />
-          <Path path="40" as="56" />
-          <Path path="42" as="43" />
-          <Path path="44" as="45" />
+          <Path path="19" as="20" />
+          <Path path="21" as="22" />
         </Paths>
       </Formula>
-      <Formula id="CompoundAcidBase_PKSim.PARAM_IsDiproticAcid" name="PARAM_IsDiproticAcid" formula="pKa_Acids_Count=2 &amp; pKa_Bases_Count = 0 ? 1 : 0">
+      <Formula id="CompoundAcidBase_PKSim.PARAM_IsMonoproticBaseMonoproticAcid" name="PARAM_IsMonoproticBaseMonoproticAcid" formula="pKa_Acids_Count=1 &amp; pKa_Bases_Count = 1 ? 1 : 0">
         <Paths>
-          <Path path="12" as="13" />
-          <Path path="16" as="17" />
+          <Path path="19" as="20" />
+          <Path path="21" as="22" />
         </Paths>
       </Formula>
-      <Formula id="CompoundAcidBase_PKSim.PARAM_IsDiproticBase" name="PARAM_IsDiproticBase" formula="pKa_Acids_Count=0 &amp; pKa_Bases_Count = 2 ? 1 : 0">
+      <Formula id="CompoundAcidBase_PKSim.PARAM_IsNeutral" name="PARAM_IsNeutral" formula="CT_0 = 0 AND CT_1 = 0 AND CT_2 = 0">
         <Paths>
-          <Path path="12" as="13" />
-          <Path path="16" as="17" />
+          <Path path="23" as="24" />
+          <Path path="25" as="26" />
+          <Path path="27" as="28" />
         </Paths>
       </Formula>
-      <Formula id="CompoundAcidBase_PKSim.PARAM_IsDiproticBaseMonoproticAcid" name="PARAM_IsDiproticBaseMonoproticAcid" formula="pKa_Acids_Count=1 &amp; pKa_Bases_Count = 2 ? 1 : 0">
+      <Formula id="CompoundAcidBase_PKSim.PARAM_HasStrongBase" name="PARAM_HasStrongBase" formula="(CT_0=1 AND pKa_0&gt;=7) OR (CT_1=1 AND pKa_1&gt;=7) OR (CT_2=1 AND pKa_2&gt;=7)">
         <Paths>
-          <Path path="12" as="13" />
-          <Path path="16" as="17" />
+          <Path path="23" as="24" />
+          <Path path="25" as="26" />
+          <Path path="27" as="28" />
+          <Path path="29" as="30" />
+          <Path path="31" as="32" />
+          <Path path="33" as="34" />
         </Paths>
       </Formula>
-      <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_TwoBases_0" name="PARAM_pKa_TwoBases_0" formula="pKa_Bases_Count=2 ? (CT0 != CT_BASE ? Min(pKa_1;pKa_2) : (CT1 != CT_BASE ? Min(pKa_0;pKa_2) : Min(pKa_0;pKa_1))) : 0">
+      <Formula id="CompoundAcidBase_PKSim.PARAM_IsTriproticAcid" name="PARAM_IsTriproticAcid" formula="pKa_Acids_Count=3 &amp; pKa_Bases_Count = 0 ? 1 : 0">
         <Paths>
-          <Path path="0" as="1" />
-          <Path path="2" as="3" />
-          <Path path="14" as="15" />
-          <Path path="6" as="7" />
-          <Path path="8" as="9" />
-          <Path path="10" as="11" />
-          <Path path="16" as="17" />
+          <Path path="19" as="20" />
+          <Path path="21" as="22" />
         </Paths>
       </Formula>
-      <Formula id="CompoundAcidBase_PKSim.PARAM_IsMonoproticBase" name="PARAM_IsMonoproticBase" formula="pKa_Acids_Count=0 &amp; pKa_Bases_Count = 1 ? 1 : 0">
+      <Formula id="CompoundAcidBase_PKSim.PARAM_IsTriproticBase" name="PARAM_IsTriproticBase" formula="pKa_Acids_Count=0 &amp; pKa_Bases_Count = 3 ? 1 : 0">
         <Paths>
-          <Path path="12" as="13" />
-          <Path path="16" as="17" />
+          <Path path="19" as="20" />
+          <Path path="21" as="22" />
         </Paths>
       </Formula>
-      <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_K3" name="PARAM_pKa_pH_WS_sol_K3" formula="F1*(1-F2)*F3">
+      <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_Acid_0" name="PARAM_pKa_Acid_0" formula="pKa_OneAcid_0+pKa_TwoAcids_0+pKa_ThreeAcids_0">
         <Paths>
-          <Path path="57" as="58" />
-          <Path path="59" as="60" />
-          <Path path="61" as="62" />
+          <Path path="35" as="36" />
+          <Path path="37" as="38" />
+          <Path path="39" as="40" />
+        </Paths>
+      </Formula>
+      <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_Acid_1" name="PARAM_pKa_Acid_1" formula="pKa_TwoAcids_1+pKa_ThreeAcids_1">
+        <Paths>
+          <Path path="41" as="42" />
+          <Path path="43" as="44" />
+        </Paths>
+      </Formula>
+      <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_Acid_2" name="PARAM_pKa_Acid_2" formula="IsTriproticAcid ? Max (pKa_0; Max (pKa_1; pKa_2)) : 0">
+        <Paths>
+          <Path path="45" as="46" />
+          <Path path="29" as="30" />
+          <Path path="31" as="32" />
+          <Path path="33" as="34" />
+        </Paths>
+      </Formula>
+      <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_Acids_Count" name="PARAM_pKa_Acids_Count" formula="(CT0 = CT_ACID ? 1 : 0) + (CT1 = CT_ACID ? 1 : 0) + (CT2 = CT_ACID ? 1 : 0)">
+        <Paths>
+          <Path path="47" as="48" />
+          <Path path="23" as="49" />
+          <Path path="25" as="50" />
+          <Path path="27" as="51" />
+        </Paths>
+      </Formula>
+      <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_Base_0" name="PARAM_pKa_Base_0" formula="pKa_OneBase_0+pKa_TwoBases_0+pKa_ThreeBases_0">
+        <Paths>
+          <Path path="52" as="53" />
+          <Path path="54" as="55" />
+          <Path path="56" as="57" />
+        </Paths>
+      </Formula>
+      <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_Base_1" name="PARAM_pKa_Base_1" formula="pKa_TwoBases_1+pKa_ThreeBases_1">
+        <Paths>
+          <Path path="58" as="59" />
+          <Path path="60" as="61" />
         </Paths>
       </Formula>
       <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_Base_2" name="PARAM_pKa_Base_2" formula="IsTriproticBase ? Max (pKa_0; Max (pKa_1; pKa_2)) : 0">
         <Paths>
-          <Path path="63" as="64" />
-          <Path path="6" as="7" />
-          <Path path="8" as="9" />
-          <Path path="10" as="11" />
+          <Path path="62" as="63" />
+          <Path path="29" as="30" />
+          <Path path="31" as="32" />
+          <Path path="33" as="34" />
         </Paths>
       </Formula>
       <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_Bases_Count" name="PARAM_pKa_Bases_Count" formula="(CT0 = CT_BASE ? 1 : 0) + (CT1 = CT_BASE ? 1 : 0) + (CT2 = CT_BASE ? 1 : 0)">
         <Paths>
-          <Path path="0" as="1" />
-          <Path path="2" as="3" />
-          <Path path="18" as="19" />
-          <Path path="14" as="15" />
+          <Path path="64" as="65" />
+          <Path path="23" as="49" />
+          <Path path="25" as="50" />
+          <Path path="27" as="51" />
         </Paths>
       </Formula>
       <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_OneAcid_0" name="PARAM_pKa_OneAcid_0" formula="pKa_Acids_Count=1 ? (CT0=CT_ACID ? pKa_0 : (CT1=CT_ACID ? pKa_1 : pKa_2)) : 0">
         <Paths>
-          <Path path="0" as="1" />
-          <Path path="2" as="3" />
-          <Path path="4" as="5" />
-          <Path path="6" as="7" />
-          <Path path="8" as="9" />
-          <Path path="10" as="11" />
-          <Path path="12" as="13" />
+          <Path path="47" as="48" />
+          <Path path="23" as="49" />
+          <Path path="25" as="50" />
+          <Path path="29" as="30" />
+          <Path path="31" as="32" />
+          <Path path="33" as="34" />
+          <Path path="19" as="20" />
         </Paths>
       </Formula>
       <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_OneBase_0" name="PARAM_pKa_OneBase_0" formula="pKa_Bases_Count=1 ? (CT0=CT_BASE ? pKa_0 : (CT1=CT_BASE ? pKa_1 : pKa_2)) : 0">
         <Paths>
-          <Path path="0" as="1" />
-          <Path path="2" as="3" />
-          <Path path="14" as="15" />
-          <Path path="6" as="7" />
-          <Path path="8" as="9" />
-          <Path path="10" as="11" />
-          <Path path="16" as="17" />
+          <Path path="64" as="65" />
+          <Path path="23" as="49" />
+          <Path path="25" as="50" />
+          <Path path="29" as="30" />
+          <Path path="31" as="32" />
+          <Path path="33" as="34" />
+          <Path path="21" as="22" />
         </Paths>
       </Formula>
       <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_F1" name="PARAM_pKa_pH_WS_sol_F1" formula="CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1">
         <Paths>
-          <Path path="0" as="1" />
-          <Path path="65" as="66" />
-          <Path path="6" as="7" />
-          <Path path="67" as="68" />
+          <Path path="66" as="67" />
+          <Path path="23" as="49" />
+          <Path path="68" as="69" />
+          <Path path="29" as="30" />
         </Paths>
       </Formula>
       <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_F2" name="PARAM_pKa_pH_WS_sol_F2" formula="CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1">
         <Paths>
-          <Path path="2" as="3" />
-          <Path path="65" as="66" />
-          <Path path="8" as="9" />
-          <Path path="67" as="68" />
+          <Path path="66" as="67" />
+          <Path path="25" as="50" />
+          <Path path="68" as="69" />
+          <Path path="31" as="32" />
         </Paths>
       </Formula>
       <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_F3" name="PARAM_pKa_pH_WS_sol_F3" formula="CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1">
         <Paths>
-          <Path path="18" as="19" />
-          <Path path="65" as="66" />
-          <Path path="10" as="11" />
-          <Path path="67" as="68" />
+          <Path path="66" as="67" />
+          <Path path="27" as="51" />
+          <Path path="68" as="69" />
+          <Path path="33" as="34" />
         </Paths>
       </Formula>
-      <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_Base_0" name="PARAM_pKa_Base_0" formula="pKa_OneBase_0+pKa_TwoBases_0+pKa_ThreeBases_0">
+      <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_K1" name="PARAM_pKa_pH_WS_sol_K1" formula="F1*F2*F3">
         <Paths>
-          <Path path="69" as="70" />
-          <Path path="71" as="72" />
-          <Path path="73" as="74" />
+          <Path path="70" as="71" />
+          <Path path="72" as="73" />
+          <Path path="74" as="75" />
         </Paths>
       </Formula>
       <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_K2" name="PARAM_pKa_pH_WS_sol_K2" formula="(1-F1)*F2*F3">
         <Paths>
-          <Path path="57" as="58" />
-          <Path path="59" as="60" />
-          <Path path="61" as="62" />
+          <Path path="70" as="71" />
+          <Path path="72" as="73" />
+          <Path path="74" as="75" />
         </Paths>
       </Formula>
-      <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_Acids_Count" name="PARAM_pKa_Acids_Count" formula="(CT0 = CT_ACID ? 1 : 0) + (CT1 = CT_ACID ? 1 : 0) + (CT2 = CT_ACID ? 1 : 0)">
+      <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_K3" name="PARAM_pKa_pH_WS_sol_K3" formula="F1*(1-F2)*F3">
         <Paths>
-          <Path path="0" as="1" />
-          <Path path="2" as="3" />
-          <Path path="18" as="19" />
-          <Path path="4" as="5" />
+          <Path path="70" as="71" />
+          <Path path="72" as="73" />
+          <Path path="74" as="75" />
         </Paths>
       </Formula>
       <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_K4" name="PARAM_pKa_pH_WS_sol_K4" formula="F1*F2*(1-F3)">
         <Paths>
-          <Path path="57" as="58" />
-          <Path path="59" as="60" />
-          <Path path="61" as="62" />
+          <Path path="70" as="71" />
+          <Path path="72" as="73" />
+          <Path path="74" as="75" />
         </Paths>
       </Formula>
       <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_K5" name="PARAM_pKa_pH_WS_sol_K5" formula="(1-F1)*(1-F2)*F3">
         <Paths>
-          <Path path="57" as="58" />
-          <Path path="59" as="60" />
-          <Path path="61" as="62" />
+          <Path path="70" as="71" />
+          <Path path="72" as="73" />
+          <Path path="74" as="75" />
         </Paths>
       </Formula>
       <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_K6" name="PARAM_pKa_pH_WS_sol_K6" formula="(1-F1)*F2*(1-F3)">
         <Paths>
-          <Path path="57" as="58" />
-          <Path path="59" as="60" />
-          <Path path="61" as="62" />
+          <Path path="70" as="71" />
+          <Path path="72" as="73" />
+          <Path path="74" as="75" />
         </Paths>
       </Formula>
       <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_K7" name="PARAM_pKa_pH_WS_sol_K7" formula="F1*(1-F2)*(1-F3)">
         <Paths>
-          <Path path="57" as="58" />
-          <Path path="59" as="60" />
-          <Path path="61" as="62" />
+          <Path path="70" as="71" />
+          <Path path="72" as="73" />
+          <Path path="74" as="75" />
         </Paths>
       </Formula>
       <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_K8" name="PARAM_pKa_pH_WS_sol_K8" formula="(1-F1)*(1-F2)*(1-F3)">
         <Paths>
-          <Path path="57" as="58" />
-          <Path path="59" as="60" />
-          <Path path="61" as="62" />
+          <Path path="70" as="71" />
+          <Path path="72" as="73" />
+          <Path path="74" as="75" />
         </Paths>
       </Formula>
       <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_ThreeAcids_0" name="PARAM_pKa_ThreeAcids_0" formula="IsTriproticAcid ? Min (pKa_0; Min (pKa_1; pKa_2)) : 0">
         <Paths>
-          <Path path="75" as="76" />
-          <Path path="6" as="7" />
-          <Path path="8" as="9" />
-          <Path path="10" as="11" />
+          <Path path="45" as="46" />
+          <Path path="29" as="30" />
+          <Path path="31" as="32" />
+          <Path path="33" as="34" />
         </Paths>
       </Formula>
       <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_ThreeAcids_1" name="PARAM_pKa_ThreeAcids_1" formula="IsTriproticAcid ? (pKa_0 &lt;= pKa_Acid_0 ? min(pKa_1; pKa_2) : (pKa_0 &gt;= pKa_Acid_2 ? max(pKa_1; pKa_2) : pKa_0)) : 0">
         <Paths>
-          <Path path="75" as="76" />
-          <Path path="6" as="7" />
-          <Path path="8" as="9" />
-          <Path path="10" as="11" />
-          <Path path="77" as="78" />
-          <Path path="79" as="80" />
+          <Path path="45" as="46" />
+          <Path path="29" as="30" />
+          <Path path="31" as="32" />
+          <Path path="33" as="34" />
+          <Path path="76" as="77" />
+          <Path path="78" as="79" />
         </Paths>
       </Formula>
       <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_ThreeBases_0" name="PARAM_pKa_ThreeBases_0" formula="IsTriproticBase ? Min (pKa_0; Min (pKa_1; pKa_2)) : 0">
         <Paths>
-          <Path path="63" as="64" />
-          <Path path="6" as="7" />
-          <Path path="8" as="9" />
-          <Path path="10" as="11" />
+          <Path path="62" as="63" />
+          <Path path="29" as="30" />
+          <Path path="31" as="32" />
+          <Path path="33" as="34" />
         </Paths>
       </Formula>
       <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_ThreeBases_1" name="PARAM_pKa_ThreeBases_1" formula="IsTriproticBase ? (pKa_0 &lt;= pKa_Base_0 ? min(pKa_1; pKa_2) : (pKa_0 &gt;= pKa_Base_2 ? max(pKa_1; pKa_2) : pKa_0)) : 0">
         <Paths>
-          <Path path="63" as="64" />
-          <Path path="6" as="7" />
-          <Path path="8" as="9" />
-          <Path path="10" as="11" />
-          <Path path="81" as="82" />
-          <Path path="83" as="84" />
-        </Paths>
-      </Formula>
-      <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_K1" name="PARAM_pKa_pH_WS_sol_K1" formula="F1*F2*F3">
-        <Paths>
-          <Path path="57" as="58" />
-          <Path path="59" as="60" />
-          <Path path="61" as="62" />
+          <Path path="62" as="63" />
+          <Path path="29" as="30" />
+          <Path path="31" as="32" />
+          <Path path="33" as="34" />
+          <Path path="80" as="81" />
+          <Path path="82" as="83" />
         </Paths>
       </Formula>
-      <Formula id="CompoundAcidBase_PKSim.PARAM_IsMonoproticBaseDiproticAcid" name="PARAM_IsMonoproticBaseDiproticAcid" formula="pKa_Acids_Count=2 &amp; pKa_Bases_Count = 1 ? 1 : 0">
-        <Paths>
-          <Path path="12" as="13" />
-          <Path path="16" as="17" />
-        </Paths>
-      </Formula>
-      <Formula id="CompoundAcidBase_PKSim.PARAM_IsMonoproticBaseMonoproticAcid" name="PARAM_IsMonoproticBaseMonoproticAcid" formula="pKa_Acids_Count=1 &amp; pKa_Bases_Count = 1 ? 1 : 0">
-        <Paths>
-          <Path path="12" as="13" />
-          <Path path="16" as="17" />
-        </Paths>
-      </Formula>
-      <Formula id="CompoundAcidBase_PKSim.PARAM_IsNeutral" name="PARAM_IsNeutral" formula="CT_0 = 0 AND CT_1 = 0 AND CT_2 = 0">
+      <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_TwoAcids_0" name="PARAM_pKa_TwoAcids_0" formula="pKa_Acids_Count=2 ? (CT0 != CT_ACID ? Min(pKa_1;pKa_2) : (CT1 != CT_ACID ? Min(pKa_0;pKa_2) : Min(pKa_0;pKa_1))) : 0">
         <Paths>
-          <Path path="0" as="85" />
-          <Path path="2" as="86" />
-          <Path path="18" as="87" />
+          <Path path="47" as="48" />
+          <Path path="23" as="49" />
+          <Path path="25" as="50" />
+          <Path path="29" as="30" />
+          <Path path="31" as="32" />
+          <Path path="33" as="34" />
+          <Path path="19" as="20" />
         </Paths>
       </Formula>
-      <Formula id="CompoundAcidBase_PKSim.PARAM_HasStrongBase" name="PARAM_HasStrongBase" formula="(CT_0=1 AND pKa_0&gt;=7) OR (CT_1=1 AND pKa_1&gt;=7) OR (CT_2=1 AND pKa_2&gt;=7)">
+      <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_TwoAcids_1" name="PARAM_pKa_TwoAcids_1" formula="pKa_Acids_Count=2 ? (CT0 != CT_ACID ? Max(pKa_1;pKa_2) : (CT1 != CT_ACID ? Max(pKa_0;pKa_2) : Max(pKa_0;pKa_1))) : 0">
         <Paths>
-          <Path path="0" as="85" />
-          <Path path="2" as="86" />
-          <Path path="18" as="87" />
-          <Path path="6" as="7" />
-          <Path path="8" as="9" />
-          <Path path="10" as="11" />
+          <Path path="47" as="48" />
+          <Path path="23" as="49" />
+          <Path path="25" as="50" />
+          <Path path="29" as="30" />
+          <Path path="31" as="32" />
+          <Path path="33" as="34" />
+          <Path path="19" as="20" />
         </Paths>
       </Formula>
-      <Formula id="CompoundAcidBase_PKSim.PARAM_IsTriproticAcid" name="PARAM_IsTriproticAcid" formula="pKa_Acids_Count=3 &amp; pKa_Bases_Count = 0 ? 1 : 0">
+      <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_TwoBases_0" name="PARAM_pKa_TwoBases_0" formula="pKa_Bases_Count=2 ? (CT0 != CT_BASE ? Min(pKa_1;pKa_2) : (CT1 != CT_BASE ? Min(pKa_0;pKa_2) : Min(pKa_0;pKa_1))) : 0">
         <Paths>
-          <Path path="12" as="13" />
-          <Path path="16" as="17" />
+          <Path path="64" as="65" />
+          <Path path="23" as="49" />
+          <Path path="25" as="50" />
+          <Path path="29" as="30" />
+          <Path path="31" as="32" />
+          <Path path="33" as="34" />
+          <Path path="21" as="22" />
         </Paths>
       </Formula>
-      <Formula id="CompoundAcidBase_PKSim.PARAM_IsTriproticBase" name="PARAM_IsTriproticBase" formula="pKa_Acids_Count=0 &amp; pKa_Bases_Count = 3 ? 1 : 0">
+      <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_TwoBases_1" name="PARAM_pKa_TwoBases_1" formula="pKa_Bases_Count=2 ? (CT0 != CT_BASE ? Max(pKa_1;pKa_2) : (CT1 != CT_BASE ? Max(pKa_0;pKa_2) : Max(pKa_0;pKa_1))) : 0">
         <Paths>
-          <Path path="12" as="13" />
-          <Path path="16" as="17" />
+          <Path path="64" as="65" />
+          <Path path="23" as="49" />
+          <Path path="25" as="50" />
+          <Path path="29" as="30" />
+          <Path path="31" as="32" />
+          <Path path="33" as="34" />
+          <Path path="21" as="22" />
         </Paths>
       </Formula>
-      <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_Base_1" name="PARAM_pKa_Base_1" formula="pKa_TwoBases_1+pKa_ThreeBases_1">
+      <Formula id="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_RefpH_Factor" name="PARAM_Solubility_pKa_RefpH_Factor" formula="K1+K2/base^(CT0^2)+K3/base^(CT1^2)+K4/base^(CT2^2)+K5/base^max(CT0+CT1;-CT0-CT1)+K6/base^max(CT0+CT2;-CT0-CT2)+K7/base^max(CT1+CT2;-CT1-CT2)+K8/base^max(CT0+CT1+CT2;-CT0-CT1-CT2)">
         <Paths>
+          <Path path="23" as="49" />
+          <Path path="25" as="50" />
+          <Path path="27" as="51" />
+          <Path path="84" as="85" />
+          <Path path="86" as="87" />
           <Path path="88" as="89" />
           <Path path="90" as="91" />
-        </Paths>
-      </Formula>
-      <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_Acid_0" name="PARAM_pKa_Acid_0" formula="pKa_OneAcid_0+pKa_TwoAcids_0+pKa_ThreeAcids_0">
-        <Paths>
           <Path path="92" as="93" />
           <Path path="94" as="95" />
           <Path path="96" as="97" />
-        </Paths>
-      </Formula>
-      <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_Acid_1" name="PARAM_pKa_Acid_1" formula="pKa_TwoAcids_1+pKa_ThreeAcids_1">
-        <Paths>
           <Path path="98" as="99" />
           <Path path="100" as="101" />
         </Paths>
       </Formula>
-      <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_Acid_2" name="PARAM_pKa_Acid_2" formula="IsTriproticAcid ? Max (pKa_0; Max (pKa_1; pKa_2)) : 0">
-        <Paths>
-          <Path path="75" as="76" />
-          <Path path="6" as="7" />
-          <Path path="8" as="9" />
-          <Path path="10" as="11" />
-        </Paths>
-      </Formula>
+      <SumFormula id="DynamicSumFormulas.PARAM_TotalDrugMass" name="PARAM_TotalDrugMass" dim="Amount" variable="P" formulaString="P_#i">
+        <Criteria>
+          <DescriptorConditions>
+            <MatchTagCondition tag="DrugMass" />
+            <MatchTagCondition tag="MOLECULE" />
+          </DescriptorConditions>
+        </Criteria>
+      </SumFormula>
       <Formula id="DiffusionCommon_PKSim.PARAM_P" name="PARAM_P" dim="Velocity" formula="IsSmallMolecule ? (MWEff *1E9 / 336) ^ (-6) * 10^LogMA / 5 * 1E-4 *1E-1: 0">
         <Paths>
-          <Path path="49" as="50" dim="48" />
-          <Path path="51" as="52" />
-          <Path path="53" as="54" dim="55" />
+          <Path path="0" as="1" dim="2" />
+          <Path path="3" as="4" />
+          <Path path="5" as="6" dim="7" />
         </Paths>
       </Formula>
       <Formula id="DistributionInVitro_PKSim.PARAM_KProt" name="PARAM_KProt" formula="(0.81 + 0.11 * 10^LogMA) / 24.92 * 5.0">
         <Paths>
-          <Path path="53" as="54" dim="55" />
+          <Path path="5" as="6" dim="7" />
         </Paths>
       </Formula>
       <Formula id="CompoundCommon.PARAM_Aqueous_diffusion_coefficient" name="PARAM_Aqueous_diffusion_coefficient" dim="Diffusion coefficient" formula="60 * 10^(-4.113-0.4609*Log10(MW * 1E9)) *1E-2">
         <Paths>
-          <Path path="46" as="47" dim="48" />
+          <Path path="16" as="17" dim="2" />
         </Paths>
       </Formula>
       <Formula id="CompoundCommon.PARAM_Ae" name="PARAM_Ae" dim="Length" formula="0,0333 * (MW * 1E9) ^ 0,4226 * 1E-8">
         <Paths>
-          <Path path="46" as="47" dim="48" />
+          <Path path="16" as="17" dim="2" />
         </Paths>
       </Formula>
       <Formula id="ConcFormula" name="ConcFormula" dim="Concentration (molar)" formula="V&gt;0 ? M/V : 0">
@@ -681,111 +684,111 @@
           <Path path="105" as="106" dim="107" />
         </Paths>
       </Formula>
-      <ConstantFormula id="JLo_YprpNUuVcfA4Kx4Ivg" dim="Amount" value="0" />
+      <ConstantFormula id="6_J3J9oQ1Ealjl77qIqeJA" dim="Amount" value="0" />
     </Formulas>
     <StringMap>
-      <Map s="..|Compound type 0" id="0" />
-      <Map s="CT0" id="1" />
-      <Map s="..|Compound type 1" id="2" />
-      <Map s="CT1" id="3" />
-      <Map s="..|CT_ACID" id="4" />
-      <Map s="CT_ACID" id="5" />
-      <Map s="..|pKa value 0" id="6" />
-      <Map s="pKa_0" id="7" />
-      <Map s="..|pKa value 1" id="8" />
-      <Map s="pKa_1" id="9" />
-      <Map s="..|pKa value 2" id="10" />
-      <Map s="pKa_2" id="11" />
-      <Map s="..|pKa_Acids_Count" id="12" />
-      <Map s="pKa_Acids_Count" id="13" />
-      <Map s="..|CT_BASE" id="14" />
-      <Map s="CT_BASE" id="15" />
-      <Map s="..|pKa_Bases_Count" id="16" />
-      <Map s="pKa_Bases_Count" id="17" />
-      <Map s="..|Compound type 2" id="18" />
-      <Map s="CT2" id="19" />
-      <Map s="..|pKa_pH_WS_sol_K1" id="20" />
-      <Map s="K1" id="21" />
-      <Map s="..|pKa_pH_WS_sol_K2" id="22" />
-      <Map s="K2" id="23" />
-      <Map s="..|pKa_pH_WS_sol_K3" id="24" />
-      <Map s="K3" id="25" />
-      <Map s="..|pKa_pH_WS_sol_K4" id="26" />
-      <Map s="K4" id="27" />
-      <Map s="..|pKa_pH_WS_sol_K5" id="28" />
-      <Map s="K5" id="29" />
-      <Map s="..|pKa_pH_WS_sol_K6" id="30" />
-      <Map s="K6" id="31" />
-      <Map s="..|pKa_pH_WS_sol_K7" id="32" />
-      <Map s="K7" id="33" />
-      <Map s="..|pKa_pH_WS_sol_K8" id="34" />
-      <Map s="K8" id="35" />
-      <Map s="..|Solubility gain per charge" id="36" />
-      <Map s="base" id="37" />
-      <Map s="..|Br" id="38" />
-      <Map s="Br" id="39" />
-      <Map s="..|Cl" id="40" />
-      <Map s="Cl" id="41" />
-      <Map s="..|F" id="42" />
-      <Map s="F" id="43" />
-      <Map s="..|I" id="44" />
-      <Map s="I" id="45" />
-      <Map s="..|Molecular weight" id="46" />
-      <Map s="MW" id="47" />
-      <Map s="Molecular weight" id="48" />
-      <Map s="..|Effective molecular weight" id="49" />
-      <Map s="MWEff" id="50" />
-      <Map s="..|Is small molecule" id="51" />
-      <Map s="IsSmallMolecule" id="52" />
-      <Map s="..|Lipophilicity" id="53" />
-      <Map s="LogMA" id="54" />
-      <Map s="Log Units" id="55" />
-      <Map s="Chlor" id="56" />
-      <Map s="..|pKa_pH_WS_sol_F1" id="57" />
-      <Map s="F1" id="58" />
-      <Map s="..|pKa_pH_WS_sol_F2" id="59" />
-      <Map s="F2" id="60" />
-      <Map s="..|pKa_pH_WS_sol_F3" id="61" />
-      <Map s="F3" id="62" />
-      <Map s="..|Is triprotic base" id="63" />
-      <Map s="IsTriproticBase" id="64" />
-      <Map s="..|CT_NEUTRAL" id="65" />
-      <Map s="CT_NEUTRAL" id="66" />
-      <Map s="..|Reference pH" id="67" />
-      <Map s="pH" id="68" />
-      <Map s="..|pKa_OneBase_0" id="69" />
-      <Map s="pKa_OneBase_0" id="70" />
-      <Map s="..|pKa_ThreeBases_0" id="71" />
-      <Map s="pKa_ThreeBases_0" id="72" />
-      <Map s="..|pKa_TwoBases_0" id="73" />
-      <Map s="pKa_TwoBases_0" id="74" />
-      <Map s="..|Is triprotic acid" id="75" />
-      <Map s="IsTriproticAcid" id="76" />
-      <Map s="..|pKa_Acid_0" id="77" />
-      <Map s="pKa_Acid_0" id="78" />
-      <Map s="..|pKa_Acid_2" id="79" />
-      <Map s="pKa_Acid_2" id="80" />
-      <Map s="..|pKa_Base_0" id="81" />
-      <Map s="pKa_Base_0" id="82" />
-      <Map s="..|pKa_Base_2" id="83" />
-      <Map s="pKa_Base_2" id="84" />
-      <Map s="CT_0" id="85" />
-      <Map s="CT_1" id="86" />
-      <Map s="CT_2" id="87" />
-      <Map s="..|pKa_ThreeBases_1" id="88" />
-      <Map s="pKa_ThreeBases_1" id="89" />
-      <Map s="..|pKa_TwoBases_1" id="90" />
-      <Map s="pKa_TwoBases_1" id="91" />
-      <Map s="..|pKa_OneAcid_0" id="92" />
-      <Map s="pKa_OneAcid_0" id="93" />
-      <Map s="..|pKa_ThreeAcids_0" id="94" />
-      <Map s="pKa_ThreeAcids_0" id="95" />
-      <Map s="..|pKa_TwoAcids_0" id="96" />
-      <Map s="pKa_TwoAcids_0" id="97" />
-      <Map s="..|pKa_ThreeAcids_1" id="98" />
-      <Map s="pKa_ThreeAcids_1" id="99" />
-      <Map s="..|pKa_TwoAcids_1" id="100" />
-      <Map s="pKa_TwoAcids_1" id="101" />
+      <Map s="..|Effective molecular weight" id="0" />
+      <Map s="MWEff" id="1" />
+      <Map s="Molecular weight" id="2" />
+      <Map s="..|Is small molecule" id="3" />
+      <Map s="IsSmallMolecule" id="4" />
+      <Map s="..|Lipophilicity" id="5" />
+      <Map s="LogMA" id="6" />
+      <Map s="Log Units" id="7" />
+      <Map s="..|Br" id="8" />
+      <Map s="Br" id="9" />
+      <Map s="..|Cl" id="10" />
+      <Map s="Cl" id="11" />
+      <Map s="..|F" id="12" />
+      <Map s="F" id="13" />
+      <Map s="..|I" id="14" />
+      <Map s="I" id="15" />
+      <Map s="..|Molecular weight" id="16" />
+      <Map s="MW" id="17" />
+      <Map s="Chlor" id="18" />
+      <Map s="..|pKa_Acids_Count" id="19" />
+      <Map s="pKa_Acids_Count" id="20" />
+      <Map s="..|pKa_Bases_Count" id="21" />
+      <Map s="pKa_Bases_Count" id="22" />
+      <Map s="..|Compound type 0" id="23" />
+      <Map s="CT_0" id="24" />
+      <Map s="..|Compound type 1" id="25" />
+      <Map s="CT_1" id="26" />
+      <Map s="..|Compound type 2" id="27" />
+      <Map s="CT_2" id="28" />
+      <Map s="..|pKa value 0" id="29" />
+      <Map s="pKa_0" id="30" />
+      <Map s="..|pKa value 1" id="31" />
+      <Map s="pKa_1" id="32" />
+      <Map s="..|pKa value 2" id="33" />
+      <Map s="pKa_2" id="34" />
+      <Map s="..|pKa_OneAcid_0" id="35" />
+      <Map s="pKa_OneAcid_0" id="36" />
+      <Map s="..|pKa_ThreeAcids_0" id="37" />
+      <Map s="pKa_ThreeAcids_0" id="38" />
+      <Map s="..|pKa_TwoAcids_0" id="39" />
+      <Map s="pKa_TwoAcids_0" id="40" />
+      <Map s="..|pKa_ThreeAcids_1" id="41" />
+      <Map s="pKa_ThreeAcids_1" id="42" />
+      <Map s="..|pKa_TwoAcids_1" id="43" />
+      <Map s="pKa_TwoAcids_1" id="44" />
+      <Map s="..|Is triprotic acid" id="45" />
+      <Map s="IsTriproticAcid" id="46" />
+      <Map s="..|CT_ACID" id="47" />
+      <Map s="CT_ACID" id="48" />
+      <Map s="CT0" id="49" />
+      <Map s="CT1" id="50" />
+      <Map s="CT2" id="51" />
+      <Map s="..|pKa_OneBase_0" id="52" />
+      <Map s="pKa_OneBase_0" id="53" />
+      <Map s="..|pKa_ThreeBases_0" id="54" />
+      <Map s="pKa_ThreeBases_0" id="55" />
+      <Map s="..|pKa_TwoBases_0" id="56" />
+      <Map s="pKa_TwoBases_0" id="57" />
+      <Map s="..|pKa_ThreeBases_1" id="58" />
+      <Map s="pKa_ThreeBases_1" id="59" />
+      <Map s="..|pKa_TwoBases_1" id="60" />
+      <Map s="pKa_TwoBases_1" id="61" />
+      <Map s="..|Is triprotic base" id="62" />
+      <Map s="IsTriproticBase" id="63" />
+      <Map s="..|CT_BASE" id="64" />
+      <Map s="CT_BASE" id="65" />
+      <Map s="..|CT_NEUTRAL" id="66" />
+      <Map s="CT_NEUTRAL" id="67" />
+      <Map s="..|Reference pH" id="68" />
+      <Map s="pH" id="69" />
+      <Map s="..|pKa_pH_WS_sol_F1" id="70" />
+      <Map s="F1" id="71" />
+      <Map s="..|pKa_pH_WS_sol_F2" id="72" />
+      <Map s="F2" id="73" />
+      <Map s="..|pKa_pH_WS_sol_F3" id="74" />
+      <Map s="F3" id="75" />
+      <Map s="..|pKa_Acid_0" id="76" />
+      <Map s="pKa_Acid_0" id="77" />
+      <Map s="..|pKa_Acid_2" id="78" />
+      <Map s="pKa_Acid_2" id="79" />
+      <Map s="..|pKa_Base_0" id="80" />
+      <Map s="pKa_Base_0" id="81" />
+      <Map s="..|pKa_Base_2" id="82" />
+      <Map s="pKa_Base_2" id="83" />
+      <Map s="..|Solubility gain per charge" id="84" />
+      <Map s="base" id="85" />
+      <Map s="..|pKa_pH_WS_sol_K1" id="86" />
+      <Map s="K1" id="87" />
+      <Map s="..|pKa_pH_WS_sol_K2" id="88" />
+      <Map s="K2" id="89" />
+      <Map s="..|pKa_pH_WS_sol_K3" id="90" />
+      <Map s="K3" id="91" />
+      <Map s="..|pKa_pH_WS_sol_K4" id="92" />
+      <Map s="K4" id="93" />
+      <Map s="..|pKa_pH_WS_sol_K5" id="94" />
+      <Map s="K5" id="95" />
+      <Map s="..|pKa_pH_WS_sol_K6" id="96" />
+      <Map s="K6" id="97" />
+      <Map s="..|pKa_pH_WS_sol_K7" id="98" />
+      <Map s="K7" id="99" />
+      <Map s="..|pKa_pH_WS_sol_K8" id="100" />
+      <Map s="K8" id="101" />
       <Map s=".." id="102" />
       <Map s="M" id="103" />
       <Map s="Amount" id="104" />
diff --git a/src/Data/Templates/Standard Observer.pkml b/src/Data/Templates/Standard Observer.pkml
index f1e12ab45..c91905a29 100644
--- a/src/Data/Templates/Standard Observer.pkml	
+++ b/src/Data/Templates/Standard Observer.pkml	
@@ -1,8 +1,8 @@
 <?xml version="1.0" encoding="utf-8"?>
-<ObserverBuildingBlock id="SJYNi9KHC0i7N6yV61xCPg" name="Standard Observer" icon="Observer" bbVersion="0" version="13">
-  <Creation createdAt="5248308555519002013" createdBy="EZZJY" creationMode="New" origin="PKSim" version="7.3.0" internalVersion="74" />
+<ObserverBuildingBlock id="jjEoYH5uVkqGX1gHrBiIKw" name="Standard Observer" icon="Observer" bbVersion="0" version="14">
+  <Creation createdAt="5248852327625293752" createdBy="Michael" creationMode="New" origin="PKSim" version="9.0" internalVersion="77" />
   <Builders>
-    <ContainerObserverBuilder id="4Q1xfEUiMEKEOFKMnj5rGw" name="Blood Cells" icon="Observer" dimension="Concentration (molar)" formula="CB5by6JAaEG8bBOTG7LZCw">
+    <ContainerObserverBuilder id="E7FJo409skygdx-fDW1hoQ" name="Blood Cells" icon="Observer" dimension="Concentration (molar)" formula="-ka4TnRjVUS0EVh8rVpdoQ">
       <ContainerCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="PeripheralVenousBlood" />
@@ -14,7 +14,7 @@
         </MoleculeNames>
       </MoleculeList>
     </ContainerObserverBuilder>
-    <AmountObserverBuilder id="RiAUgAT-0Eymc-jTgRGH1w" name="Concentration in container" icon="Observer" dimension="Concentration (molar)" formula="8jK_sDqD-02dr2cZDgnQMA">
+    <AmountObserverBuilder id="2sFHk23yFUCwbDCk1ZBwhw" name="Concentration in container" icon="Observer" dimension="Concentration (molar)" formula="oGVK-BNnVUWfR00M-CZXmw">
       <ContainerCriteria>
         <DescriptorConditions>
           <NotMatchTagCondition tag="Gallbladder" />
@@ -27,7 +27,7 @@
         </MoleculeNames>
       </MoleculeList>
     </AmountObserverBuilder>
-    <ContainerObserverBuilder id="ASA-nbDr9UWLNkNbZYm5fA" name="Concentration in container (Liver, BloodCells)" icon="Observer" dimension="Concentration (molar)" formula="ayKiTvoDlEeRv4rY0ZhAtw">
+    <ContainerObserverBuilder id="aaDTxFLVykaTpC9gSat1IQ" name="Concentration in container (Liver, BloodCells)" icon="Observer" dimension="Concentration (molar)" formula="LkzSUhI0O0S_f74iHDUdjQ">
       <ContainerCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="BloodCells" />
@@ -42,7 +42,7 @@
         </MoleculeNames>
       </MoleculeList>
     </ContainerObserverBuilder>
-    <ContainerObserverBuilder id="p65hpm9OXEa3cz2u3hVYcw" name="Concentration in container (Liver, Interstitial)" icon="Observer" dimension="Concentration (molar)" formula="nQkSHkUwUkqgAJ523dTfvA">
+    <ContainerObserverBuilder id="54DHzX2VKEuvDbCfEHGoJA" name="Concentration in container (Liver, Interstitial)" icon="Observer" dimension="Concentration (molar)" formula="U3CqIaFRLEeraVp8J4_RkA">
       <ContainerCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="Interstitial" />
@@ -57,7 +57,7 @@
         </MoleculeNames>
       </MoleculeList>
     </ContainerObserverBuilder>
-    <ContainerObserverBuilder id="4zUgL2VOdkWDR_oOx6ysKA" name="Concentration in container (Liver, Intracellular)" icon="Observer" dimension="Concentration (molar)" formula="VdN7PXM5502838s9KG9Q2A">
+    <ContainerObserverBuilder id="f9jk8uDK6E-J2E62ZsQ5hQ" name="Concentration in container (Liver, Intracellular)" icon="Observer" dimension="Concentration (molar)" formula="LoAjccomM0qdLift5dH9IQ">
       <ContainerCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="Intracellular" />
@@ -72,7 +72,7 @@
         </MoleculeNames>
       </MoleculeList>
     </ContainerObserverBuilder>
-    <ContainerObserverBuilder id="A__MoZFpx0CspIwUDv6A8A" name="Concentration in container (Liver, Plasma)" icon="Observer" dimension="Concentration (molar)" formula="2OpcLIGPLEWuPwCF-nGlZQ">
+    <ContainerObserverBuilder id="388gIlTEoU60-6gUqNkkoA" name="Concentration in container (Liver, Plasma)" icon="Observer" dimension="Concentration (molar)" formula="7M0Wbgvlv0u9d7s1x2tc0A">
       <ContainerCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="Liver" />
@@ -87,7 +87,7 @@
         </MoleculeNames>
       </MoleculeList>
     </ContainerObserverBuilder>
-    <AmountObserverBuilder id="2O5uA4EA9UC-hVU9amhE5g" name="Concentration in feces" icon="Observer" dimension="Concentration (molar)" formula="8jK_sDqD-02dr2cZDgnQMA">
+    <AmountObserverBuilder id="8VoKR_Ky1E-RlYVh3E2Ldw" name="Concentration in feces" icon="Observer" dimension="Concentration (molar)" formula="oGVK-BNnVUWfR00M-CZXmw">
       <ContainerCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="Feces" />
@@ -100,7 +100,7 @@
         </MoleculeNames>
       </MoleculeList>
     </AmountObserverBuilder>
-    <AmountObserverBuilder id="H1932jDAvEa8m1SpoBKOzQ" name="Concentration in lumen" icon="Observer" dimension="Concentration (molar)" formula="BtxQrfj8PkC2y5P3_LwV8g">
+    <AmountObserverBuilder id="cZEkYgfNU0G6HdSmfTE-jw" name="Concentration in lumen" icon="Observer" dimension="Concentration (molar)" formula="F5gRTonY7EqyrCAwy_dYtQ">
       <ContainerCriteria>
         <DescriptorConditions>
           <NotMatchTagCondition tag="Feces" />
@@ -113,7 +113,7 @@
         </MoleculeNames>
       </MoleculeList>
     </AmountObserverBuilder>
-    <ContainerObserverBuilder id="Ip34gkZ0D02QjQos_wE3Cw" name="Fraction dissolved" icon="Observer" dimension="Fraction" formula="n_IqchsrvUOe-SOTkjdwYQ">
+    <ContainerObserverBuilder id="RuOoOSt0okGrmNVYFKeDjw" name="Fraction dissolved" icon="Observer" dimension="Fraction" formula="yo8iZJrhKE6qZKiukp4dFw">
       <ContainerCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="Lumen" />
@@ -126,7 +126,7 @@
         </MoleculeNames>
       </MoleculeList>
     </ContainerObserverBuilder>
-    <ContainerObserverBuilder id="fnh2azBNokaGK61LhhGacQ" name="Fraction of oral drug mass absorbed into mucosa" icon="Observer" dimension="Fraction" formula="9sBtjXNhLkGH_O43MTi13g">
+    <ContainerObserverBuilder id="fuhsn_pmdU6WMJPgcKDNEg" name="Fraction of oral drug mass absorbed into mucosa" icon="Observer" dimension="Fraction" formula="xd_oeNuS3UqjdFAXh5T4DQ">
       <ContainerCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="Lumen" />
@@ -139,7 +139,7 @@
         </MoleculeNames>
       </MoleculeList>
     </ContainerObserverBuilder>
-    <ContainerObserverBuilder id="iXI7AbSQWkCcidvgSEAV9A" name="Fraction of oral drug mass absorbed into mucosa segment" icon="Observer" dimension="Fraction" formula="nfXHkn2WZk-_7XPkasMHQw">
+    <ContainerObserverBuilder id="9UNdynaJ8063kiTgF5wt1A" name="Fraction of oral drug mass absorbed into mucosa segment" icon="Observer" dimension="Fraction" formula="IgqrKYoZiEqfAaXbcEMuBg">
       <ContainerCriteria>
         <DescriptorConditions>
           <NotMatchTagCondition tag="Feces" />
@@ -153,7 +153,7 @@
         </MoleculeNames>
       </MoleculeList>
     </ContainerObserverBuilder>
-    <ContainerObserverBuilder id="3ItaKPZeckChF_q-q3GwUw" name="Interstitial Unbound" icon="Observer" dimension="Concentration (molar)" formula="ve7qKekEok61HrAGaL_d-Q">
+    <ContainerObserverBuilder id="5TzZbQ1uN0S4wp5Xy8F3dg" name="Interstitial Unbound" icon="Observer" dimension="Concentration (molar)" formula="4nfMqbsq-kWo8L3c-2ObbA">
       <ContainerCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="TissueOrgan" />
@@ -165,7 +165,7 @@
         </MoleculeNames>
       </MoleculeList>
     </ContainerObserverBuilder>
-    <ContainerObserverBuilder id="HCBQDz_xhkyG5Cnkkpsl7w" name="Interstitial Unbound (Liver)" icon="Observer" dimension="Concentration (molar)" formula="EzwPJ6kA7EWgrdoZa51teQ">
+    <ContainerObserverBuilder id="H3EFm-zqrEq4_RJ9liFK5w" name="Interstitial Unbound (Liver)" icon="Observer" dimension="Concentration (molar)" formula="m0Z41HGNXUqpwribfF6JfA">
       <ContainerCriteria>
         <DescriptorConditions>
           <NotMatchTagCondition tag="BloodCells" />
@@ -185,7 +185,7 @@
         </MoleculeNames>
       </MoleculeList>
     </ContainerObserverBuilder>
-    <ContainerObserverBuilder id="--ogGiqn70WXInlha5GwyQ" name="Intracellular Unbound" icon="Observer" dimension="Concentration (molar)" formula="7we2FjgN20a6IipC86HSlw">
+    <ContainerObserverBuilder id="gd2aW7887EyPW-QzrX2ssQ" name="Intracellular Unbound" icon="Observer" dimension="Concentration (molar)" formula="CotDsEmgfkCu6WA0lhYqUA">
       <ContainerCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="TissueOrgan" />
@@ -197,7 +197,7 @@
         </MoleculeNames>
       </MoleculeList>
     </ContainerObserverBuilder>
-    <ContainerObserverBuilder id="7zVrsw-jNEiA35yoO9Y3JA" name="Intracellular Unbound (Liver)" icon="Observer" dimension="Concentration (molar)" formula="nMoxKmPBlEKxhhF9mD5PRg">
+    <ContainerObserverBuilder id="KSj8wE7s0UCDQJpW3N1kFA" name="Intracellular Unbound (Liver)" icon="Observer" dimension="Concentration (molar)" formula="bTwmF9p_nUit-O1wsA_4tA">
       <ContainerCriteria>
         <DescriptorConditions>
           <NotMatchTagCondition tag="BloodCells" />
@@ -217,7 +217,7 @@
         </MoleculeNames>
       </MoleculeList>
     </ContainerObserverBuilder>
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+    <ContainerObserverBuilder id="7zCSmx9fpUaCA7rjt_XrkQ" name="Plasma (Peripheral Venous Blood)" icon="Observer" dimension="Concentration (molar)" formula="MTwN8N2PzUCIbx-Y45UZqg">
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@@ -229,7 +229,7 @@
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+    <AmountObserverBuilder id="m64oROYNZEerkGmEwAylLA" name="Plasma Unbound" icon="Observer" dimension="Concentration (molar)" formula="wjiENQf_jEm-STFx5MiOIw">
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@@ -242,7 +242,7 @@
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+    <ContainerObserverBuilder id="9PwECQfiX0yBA8aVW_YDGw" name="Plasma Unbound (Peripheral Venous Blood)" icon="Observer" dimension="Concentration (molar)" formula="cyQaqOJAfESKkIexUbXMjw">
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@@ -254,7 +254,7 @@
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@@ -268,7 +268,7 @@
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+    <ContainerObserverBuilder id="WvLRxs3SMU6YFB2DRJK_IQ" name="Tissue (Liver)" icon="Observer" dimension="Concentration (molar)" formula="EXtT5bO0KE6uRR0cAzekcQ">
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@@ -290,7 +290,7 @@
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@@ -316,7 +316,7 @@
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@@ -330,7 +330,7 @@
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+    <ContainerObserverBuilder id="B48Sl0pT1k-rBb0wlfPzJA" name="Whole Blood (Peripheral Venous Blood)" icon="Observer" dimension="Concentration (molar)" formula="HKHOoh17D0elFq6F65N-0A">
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@@ -342,7 +342,7 @@
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+    <AmountObserverBuilder id="-gwcKbSGkE2h4YozubKRCw" name="Fraction excreted to urine" icon="Observer" dimension="Fraction" formula="WOGW7vOe5kWWPgensWo4Rg">
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@@ -354,7 +354,7 @@
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@@ -366,7 +366,7 @@
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@@ -381,7 +381,7 @@
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+      <Formula id="xd_oeNuS3UqjdFAXh5T4DQ" name="OBS_FractionAbsorbedToMucosa" dim="Fraction" formula="OralDrugMass&gt;0.0 ?  MassAbsorbed/OralDrugMass : 0">
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+      <Formula id="cyQaqOJAfESKkIexUbXMjw" name="OBS_PlasmaUnbound_PeripheralVenousBlood" dim="Concentration (molar)" formula="(fQ_art*C_pls_art+fQ_bon*C_pls_bon+fQ_fat*C_pls_fat+fQ_mus*C_pls_mus+fQ_skn*C_pls_skn)*fu">
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+          <Path path="109" as="110" dim="2" />
+          <Path path="111" as="112" dim="2" />
+          <Path path="113" as="114" dim="2" />
+          <Path path="115" as="116" dim="2" />
           <Path path="117" as="118" dim="2" />
-          <Path path="119" as="120" dim="2" />
-          <Path path="121" as="122" dim="2" />
-          <Path path="123" as="124" dim="2" />
-          <Path path="125" as="126" dim="2" />
-          <Path path="129" as="130" dim="13" />
+          <Path path="120" as="121" dim="13" />
           <Path path="11" as="12" dim="13" />
           <Path path="14" as="15" dim="13" />
           <Path path="16" as="17" dim="13" />
@@ -539,129 +535,129 @@
           <Path path="20" as="21" dim="13" />
         </Paths>
       </Formula>
-      <Formula id="wjMlP1uKKUSY0tvXauvy2g" name="OBS_Tissue" dim="Concentration (molar)" formula="(f_int*C_int+f_cell*C_cell)/(f_int+f_cell)">
+      <Formula id="QKCugMmD9Ui3b-zmjuZcXg" name="OBS_Tissue" dim="Concentration (molar)" formula="(f_int*C_int+f_cell*C_cell)/(f_int+f_cell)">
         <Paths>
-          <Path path="131" as="132" />
-          <Path path="133" as="134" />
-          <Path path="109" as="110" dim="2" />
+          <Path path="122" as="123" />
+          <Path path="124" as="125" />
           <Path path="101" as="102" dim="2" />
+          <Path path="93" as="94" dim="2" />
         </Paths>
       </Formula>
-      <Formula id="NFboG4tyRUOCooCzWbPAZw" name="OBS_Tissue_liv" dim="Concentration (molar)" formula="(C_int_prp * V_int_prp + C_int_prc * V_int_prc + C_cell_prp * V_cell_prp + C_cell_prc * V_cell_prc)/(V_int_prp+V_int_prc+V_cell_prp)">
+      <Formula id="EXtT5bO0KE6uRR0cAzekcQ" name="OBS_Tissue_liv" dim="Concentration (molar)" formula="(C_int_prp * V_int_prp + C_int_prc * V_int_prc + C_cell_prp * V_cell_prp + C_cell_prc * V_cell_prc)/(V_int_prp+V_int_prc+V_cell_prp)">
         <Paths>
-          <Path path="36" as="37" dim="27" />
-          <Path path="38" as="39" dim="27" />
-          <Path path="44" as="45" dim="27" />
-          <Path path="46" as="47" dim="27" />
-          <Path path="48" as="49" dim="2" />
-          <Path path="50" as="51" dim="2" />
-          <Path path="40" as="41" dim="2" />
-          <Path path="42" as="43" dim="2" />
+          <Path path="33" as="34" dim="26" />
+          <Path path="35" as="36" dim="26" />
+          <Path path="41" as="42" dim="26" />
+          <Path path="43" as="44" dim="26" />
+          <Path path="45" as="46" dim="2" />
+          <Path path="47" as="48" dim="2" />
+          <Path path="37" as="38" dim="2" />
+          <Path path="39" as="40" dim="2" />
         </Paths>
       </Formula>
-      <Formula id="DZPJ0L5KMUu3jGU_hjNnkQ" name="OBS_Tissue_LargeIntestine" dim="Concentration (molar)" formula="(M_int + M_cell + M_int_cae + M_cell_cae + M_int_colasc + M_cell_colasc + M_int_coltrans + M_cell_coltrans + M_int_coldesc + M_cell_coldesc + M_int_colsigm + M_cell_colsigm + M_int_rect + M_cell_rect)/(V_int + V_cell + V_int_cae + V_cell_cae + V_int_colasc + V_cell_colasc + V_int_coltrans + V_cell_coltrans + V_int_coldesc + V_cell_coldesc + V_int_colsigm + V_cell_colsigm + V_int_rect + V_cell_rect)">
+      <Formula id="vL2zD4UBW0GHpkOmQ9OfbA" name="OBS_Tissue_LargeIntestine" dim="Concentration (molar)" formula="(M_int + M_cell + M_int_cae + M_cell_cae + M_int_colasc + M_cell_colasc + M_int_coltrans + M_cell_coltrans + M_int_coldesc + M_cell_coldesc + M_int_colsigm + M_cell_colsigm + M_int_rect + M_cell_rect)/(V_int + V_cell + V_int_cae + V_cell_cae + V_int_colasc + V_cell_colasc + V_int_coltrans + V_cell_coltrans + V_int_coldesc + V_cell_coldesc + V_int_colsigm + V_cell_colsigm + V_int_rect + V_cell_rect)">
         <Paths>
-          <Path path="135" as="136" dim="27" />
-          <Path path="137" as="138" dim="27" />
-          <Path path="139" as="140" dim="27" />
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-          <Path path="145" as="146" dim="27" />
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-          <Path path="151" as="152" dim="27" />
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-          <Path path="155" as="156" dim="27" />
-          <Path path="157" as="158" dim="27" />
-          <Path path="159" as="160" dim="27" />
-          <Path path="161" as="162" dim="27" />
-          <Path path="163" as="164" dim="24" />
-          <Path path="165" as="166" dim="24" />
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-          <Path path="169" as="170" dim="24" />
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-          <Path path="181" as="182" dim="24" />
-          <Path path="183" as="184" dim="24" />
-          <Path path="185" as="186" dim="24" />
-          <Path path="187" as="188" dim="24" />
-          <Path path="189" as="190" dim="24" />
+          <Path path="126" as="127" dim="26" />
+          <Path path="128" as="129" dim="26" />
+          <Path path="130" as="131" dim="26" />
+          <Path path="132" as="133" dim="26" />
+          <Path path="134" as="135" dim="26" />
+          <Path path="136" as="137" dim="26" />
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+          <Path path="140" as="141" dim="26" />
+          <Path path="142" as="143" dim="26" />
+          <Path path="144" as="145" dim="26" />
+          <Path path="146" as="147" dim="26" />
+          <Path path="148" as="149" dim="26" />
+          <Path path="150" as="151" dim="26" />
+          <Path path="152" as="153" dim="26" />
+          <Path path="154" as="155" dim="61" />
+          <Path path="156" as="157" dim="61" />
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+          <Path path="160" as="161" dim="61" />
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+          <Path path="178" as="179" dim="61" />
+          <Path path="180" as="181" dim="61" />
         </Paths>
       </Formula>
-      <Formula id="vJhgmHhsOU-I_hUGUsnt1Q" name="OBS_Tissue_SmallIntestine" dim="Concentration (molar)" formula="(M_int + M_cell + M_int_duo + M_cell_duo + M_int_uje + M_cell_uje + M_int_lje + M_cell_lje + M_int_uil + M_cell_uil + M_int_lil + M_cell_lil)/(V_int + V_cell + V_int_duo + V_cell_duo + V_int_uje + V_cell_uje + V_int_lje + V_cell_lje + V_int_uil + V_cell_uil + V_int_lil + V_cell_lil)">
+      <Formula id="WvVQnHbGhEW9Q2EoJfO1sg" name="OBS_Tissue_SmallIntestine" dim="Concentration (molar)" formula="(M_int + M_cell + M_int_duo + M_cell_duo + M_int_uje + M_cell_uje + M_int_lje + M_cell_lje + M_int_uil + M_cell_uil + M_int_lil + M_cell_lil)/(V_int + V_cell + V_int_duo + V_cell_duo + V_int_uje + V_cell_uje + V_int_lje + V_cell_lje + V_int_uil + V_cell_uil + V_int_lil + V_cell_lil)">
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-          <Path path="191" as="136" dim="27" />
-          <Path path="192" as="193" dim="27" />
-          <Path path="194" as="195" dim="27" />
-          <Path path="196" as="197" dim="27" />
-          <Path path="198" as="199" dim="27" />
-          <Path path="200" as="201" dim="27" />
-          <Path path="202" as="150" dim="27" />
-          <Path path="203" as="204" dim="27" />
-          <Path path="205" as="206" dim="27" />
-          <Path path="207" as="208" dim="27" />
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-          <Path path="211" as="212" dim="27" />
-          <Path path="213" as="164" dim="24" />
-          <Path path="214" as="215" dim="24" />
-          <Path path="216" as="217" dim="24" />
-          <Path path="218" as="219" dim="24" />
-          <Path path="220" as="221" dim="24" />
-          <Path path="222" as="223" dim="24" />
-          <Path path="224" as="178" dim="24" />
-          <Path path="225" as="226" dim="24" />
-          <Path path="227" as="228" dim="24" />
-          <Path path="229" as="230" dim="24" />
-          <Path path="231" as="232" dim="24" />
-          <Path path="233" as="234" dim="24" />
+          <Path path="182" as="127" dim="26" />
+          <Path path="183" as="184" dim="26" />
+          <Path path="185" as="186" dim="26" />
+          <Path path="187" as="188" dim="26" />
+          <Path path="189" as="190" dim="26" />
+          <Path path="191" as="192" dim="26" />
+          <Path path="193" as="141" dim="26" />
+          <Path path="194" as="195" dim="26" />
+          <Path path="196" as="197" dim="26" />
+          <Path path="198" as="199" dim="26" />
+          <Path path="200" as="201" dim="26" />
+          <Path path="202" as="203" dim="26" />
+          <Path path="204" as="155" dim="61" />
+          <Path path="205" as="206" dim="61" />
+          <Path path="207" as="208" dim="61" />
+          <Path path="209" as="210" dim="61" />
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+          <Path path="215" as="169" dim="61" />
+          <Path path="216" as="217" dim="61" />
+          <Path path="218" as="219" dim="61" />
+          <Path path="220" as="221" dim="61" />
+          <Path path="222" as="223" dim="61" />
+          <Path path="224" as="225" dim="61" />
         </Paths>
       </Formula>
-      <Formula id="jX2knpiQnEKbLR8Kf5Livg" name="OBS_WholeBlood" dim="Concentration (molar)" formula="(1 - HCT) * C_pls+HCT * C_bc">
+      <Formula id="-iy4oCb6bkSFGRrru74ENg" name="OBS_WholeBlood" dim="Concentration (molar)" formula="(1 - HCT) * C_pls+HCT * C_bc">
         <Paths>
-          <Path path="235" as="236" dim="2" />
-          <Path path="237" as="128" dim="2" />
-          <Path path="238" as="239" />
+          <Path path="226" as="227" dim="2" />
+          <Path path="228" as="119" dim="2" />
+          <Path path="229" as="230" />
         </Paths>
       </Formula>
-      <Formula id="9EarmK80Z0Sv61Y1eIIl_g" name="OBS_WholeBlood_PeripheralVenousBlood" dim="Concentration (molar)" formula="(1-HCT)*(fQ_art*C_pls_art+fQ_bon*C_pls_bon+fQ_fat*C_pls_fat+fQ_mus*C_pls_mus+fQ_skn*C_pls_skn) + HCT*(fQ_art*C_bc_art+fQ_bon*C_bc_bon+fQ_fat*C_bc_fat+fQ_mus*C_bc_mus+fQ_skn*C_bc_skn)">
+      <Formula id="HKHOoh17D0elFq6F65N-0A" name="OBS_WholeBlood_PeripheralVenousBlood" dim="Concentration (molar)" formula="(1-HCT)*(fQ_art*C_pls_art+fQ_bon*C_pls_bon+fQ_fat*C_pls_fat+fQ_mus*C_pls_mus+fQ_skn*C_pls_skn) + HCT*(fQ_art*C_bc_art+fQ_bon*C_bc_bon+fQ_fat*C_bc_fat+fQ_mus*C_bc_mus+fQ_skn*C_bc_skn)">
         <Paths>
           <Path path="0" as="1" dim="2" />
           <Path path="3" as="4" dim="2" />
           <Path path="5" as="6" dim="2" />
           <Path path="7" as="8" dim="2" />
           <Path path="9" as="10" dim="2" />
+          <Path path="109" as="110" dim="2" />
+          <Path path="111" as="112" dim="2" />
+          <Path path="113" as="114" dim="2" />
+          <Path path="115" as="116" dim="2" />
           <Path path="117" as="118" dim="2" />
-          <Path path="119" as="120" dim="2" />
-          <Path path="121" as="122" dim="2" />
-          <Path path="123" as="124" dim="2" />
-          <Path path="125" as="126" dim="2" />
           <Path path="11" as="12" dim="13" />
           <Path path="14" as="15" dim="13" />
           <Path path="16" as="17" dim="13" />
           <Path path="18" as="19" dim="13" />
           <Path path="20" as="21" dim="13" />
-          <Path path="238" as="239" />
+          <Path path="229" as="230" />
         </Paths>
       </Formula>
-      <Formula id="t9lLIwX_90Kyrua3iXBMnw" name="FractionObserver" dim="Fraction" formula="TotalDrugMass&gt;0 ? M/TotalDrugMass : 0">
+      <Formula id="WOGW7vOe5kWWPgensWo4Rg" name="FractionObserver" dim="Fraction" formula="TotalDrugMass&gt;0 ? M/TotalDrugMass : 0">
         <Paths>
-          <Path path="22" as="23" dim="24" />
-          <Path path="240" as="241" dim="24" />
+          <Path path="231" as="232" dim="61" />
+          <Path path="233" as="234" dim="61" />
         </Paths>
       </Formula>
-      <Formula id="Zv-RfZJ4VUq4b3Lkx0X1ew" name="FractionObserver" dim="Fraction" formula="TotalDrugMass&gt;0 ? M/TotalDrugMass : 0">
+      <Formula id="D6B8ES9CmUqOg9aKQjdJBg" name="FractionObserver" dim="Fraction" formula="TotalDrugMass&gt;0 ? M/TotalDrugMass : 0">
         <Paths>
-          <Path path="22" as="23" dim="24" />
-          <Path path="240" as="241" dim="24" />
+          <Path path="231" as="232" dim="61" />
+          <Path path="233" as="234" dim="61" />
         </Paths>
       </Formula>
-      <Formula id="awGZ5JG8x06ONB1gSmMEBA" name="FractionObserver" dim="Fraction" formula="TotalDrugMass&gt;0 ? M/TotalDrugMass : 0">
+      <Formula id="Ts11makhb0mvGGauUZ5jvw" name="FractionObserver" dim="Fraction" formula="TotalDrugMass&gt;0 ? M/TotalDrugMass : 0">
         <Paths>
-          <Path path="22" as="23" dim="24" />
-          <Path path="240" as="241" dim="24" />
+          <Path path="231" as="232" dim="61" />
+          <Path path="233" as="234" dim="61" />
         </Paths>
       </Formula>
     </Formulas>
@@ -688,226 +684,219 @@
       <Map s="fQ_mus" id="19" />
       <Map s="Organism|Skin|Peripheral blood flow fraction" id="20" />
       <Map s="fQ_skn" id="21" />
-      <Map s=".." id="22" />
-      <Map s="M" id="23" />
-      <Map s="Amount" id="24" />
-      <Map s="..|..|Volume" id="25" />
-      <Map s="V" id="26" />
-      <Map s="Volume" id="27" />
-      <Map s="Organism|Liver|Pericentral|BloodCells|Volume" id="28" />
-      <Map s="V_bc_prc" id="29" />
-      <Map s="Organism|Liver|Periportal|BloodCells|Volume" id="30" />
-      <Map s="V_bc_prp" id="31" />
-      <Map s="Organism|Liver|Pericentral|BloodCells|MOLECULE|Concentration" id="32" />
-      <Map s="C_bc_prc" id="33" />
-      <Map s="Organism|Liver|Periportal|BloodCells|MOLECULE|Concentration" id="34" />
-      <Map s="C_bc_prp" id="35" />
-      <Map s="Organism|Liver|Pericentral|Interstitial|Volume" id="36" />
-      <Map s="V_int_prc" id="37" />
-      <Map s="Organism|Liver|Periportal|Interstitial|Volume" id="38" />
-      <Map s="V_int_prp" id="39" />
-      <Map s="Organism|Liver|Pericentral|Interstitial|MOLECULE|Concentration" id="40" />
-      <Map s="C_int_prc" id="41" />
-      <Map s="Organism|Liver|Periportal|Interstitial|MOLECULE|Concentration" id="42" />
-      <Map s="C_int_prp" id="43" />
-      <Map s="Organism|Liver|Pericentral|Intracellular|Volume" id="44" />
-      <Map s="V_cell_prc" id="45" />
-      <Map s="Organism|Liver|Periportal|Intracellular|Volume" id="46" />
-      <Map s="V_cell_prp" id="47" />
-      <Map s="Organism|Liver|Pericentral|Intracellular|MOLECULE|Concentration" id="48" />
-      <Map s="C_cell_prc" id="49" />
-      <Map s="Organism|Liver|Periportal|Intracellular|MOLECULE|Concentration" id="50" />
-      <Map s="C_cell_prp" id="51" />
-      <Map s="Organism|Liver|Pericentral|Plasma|Volume" id="52" />
-      <Map s="V_pls_prc" id="53" />
-      <Map s="Organism|Liver|Periportal|Plasma|Volume" id="54" />
-      <Map s="V_pls_prp" id="55" />
-      <Map s="Organism|Liver|Pericentral|Plasma|MOLECULE|Concentration" id="56" />
-      <Map s="C_pls_prc" id="57" />
-      <Map s="Organism|Liver|Periportal|Plasma|MOLECULE|Concentration" id="58" />
-      <Map s="C_pls_prp" id="59" />
-      <Map s="..|Solubility" id="60" />
-      <Map s="Solubility" id="61" />
-      <Map s="Concentration (mass)" id="62" />
-      <Map s="MOLECULE|Molecular weight" id="63" />
-      <Map s="MW" id="64" />
-      <Map s="Molecular weight" id="65" />
-      <Map s="..|..|Liquid" id="66" />
-      <Map s="Liquid" id="67" />
-      <Map s="Organism|Lumen|Caecum|MOLECULE" id="68" />
-      <Map s="M_cae" id="69" />
-      <Map s="Organism|Lumen|ColonAscendens|MOLECULE" id="70" />
-      <Map s="M_colasc" id="71" />
-      <Map s="Organism|Lumen|ColonDescendens|MOLECULE" id="72" />
-      <Map s="M_coldesc" id="73" />
-      <Map s="Organism|Lumen|ColonSigmoid|MOLECULE" id="74" />
-      <Map s="M_colsigm" id="75" />
-      <Map s="Organism|Lumen|ColonTransversum|MOLECULE" id="76" />
-      <Map s="M_coltrans" id="77" />
-      <Map s="Organism|Lumen|Duodenum|MOLECULE" id="78" />
-      <Map s="M_duo" id="79" />
-      <Map s="Organism|Lumen|Feces|MOLECULE" id="80" />
-      <Map s="M_fec" id="81" />
-      <Map s="Organism|Lumen|LowerIleum|MOLECULE" id="82" />
-      <Map s="M_lil" id="83" />
-      <Map s="Organism|Lumen|LowerJejunum|MOLECULE" id="84" />
-      <Map s="M_lje" id="85" />
-      <Map s="Organism|Lumen|Rectum|MOLECULE" id="86" />
-      <Map s="M_rect" id="87" />
-      <Map s="Organism|Lumen|Stomach|MOLECULE" id="88" />
-      <Map s="M_sto" id="89" />
-      <Map s="Organism|Lumen|UpperIleum|MOLECULE" id="90" />
-      <Map s="M_uil" id="91" />
-      <Map s="Organism|Lumen|UpperJejunum|MOLECULE" id="92" />
-      <Map s="M_uje" id="93" />
-      <Map s="Neighborhoods|Lumen_sto_Lumen_duo|MOLECULE|Oral mass absorbed" id="94" />
-      <Map s="Mabs_Mucosa" id="95" />
-      <Map s="MOLECULE|Total oral drug mass" id="96" />
-      <Map s="TotalOralDrugMass" id="97" />
-      <Map s="MassAbsorbed" id="98" />
-      <Map s="OralDrugMass" id="99" />
-      <Map s="..|Oral mass absorbed segment" id="100" />
-      <Map s="..|..|Interstitial|MOLECULE|Concentration" id="101" />
-      <Map s="C_int" id="102" />
-      <Map s="..|..|Interstitial|MOLECULE|Partition coefficient (water/container)" id="103" />
-      <Map s="K_water_int" id="104" />
-      <Map s="Organism|Liver|Pericentral|Interstitial|MOLECULE|Partition coefficient (water/container)" id="105" />
-      <Map s="K_water_int_prc" id="106" />
-      <Map s="Organism|Liver|Periportal|Interstitial|MOLECULE|Partition coefficient (water/container)" id="107" />
-      <Map s="K_water_int_prp" id="108" />
-      <Map s="..|..|Intracellular|MOLECULE|Concentration" id="109" />
-      <Map s="C_cell" id="110" />
-      <Map s="..|..|Intracellular|MOLECULE|Partition coefficient (water/container)" id="111" />
-      <Map s="K_water_cell" id="112" />
-      <Map s="Organism|Liver|Pericentral|Intracellular|MOLECULE|Partition coefficient (water/container)" id="113" />
-      <Map s="K_water_cell_prc" id="114" />
-      <Map s="Organism|Liver|Periportal|Intracellular|MOLECULE|Partition coefficient (water/container)" id="115" />
-      <Map s="K_water_cell_prp" id="116" />
-      <Map s="Organism|ArterialBlood|Plasma|MOLECULE|Concentration" id="117" />
-      <Map s="C_pls_art" id="118" />
-      <Map s="Organism|Bone|Plasma|MOLECULE|Concentration" id="119" />
-      <Map s="C_pls_bon" id="120" />
-      <Map s="Organism|Fat|Plasma|MOLECULE|Concentration" id="121" />
-      <Map s="C_pls_fat" id="122" />
-      <Map s="Organism|Muscle|Plasma|MOLECULE|Concentration" id="123" />
-      <Map s="C_pls_mus" id="124" />
-      <Map s="Organism|Skin|Plasma|MOLECULE|Concentration" id="125" />
-      <Map s="C_pls_skn" id="126" />
-      <Map s="..|Concentration" id="127" />
-      <Map s="C_pls" id="128" />
-      <Map s="MOLECULE|Fraction unbound (plasma)" id="129" />
-      <Map s="fu" id="130" />
-      <Map s="..|..|Fraction interstitial" id="131" />
-      <Map s="f_int" id="132" />
-      <Map s="..|..|Fraction intracellular" id="133" />
-      <Map s="f_cell" id="134" />
-      <Map s="Organism|LargeIntestine|Interstitial|Volume" id="135" />
-      <Map s="V_int" id="136" />
-      <Map s="Organism|LargeIntestine|Mucosa|Caecum|Interstitial|Volume" id="137" />
-      <Map s="V_int_cae" id="138" />
-      <Map s="Organism|LargeIntestine|Mucosa|ColonAscendens|Interstitial|Volume" id="139" />
-      <Map s="V_int_colasc" id="140" />
-      <Map s="Organism|LargeIntestine|Mucosa|ColonDescendens|Interstitial|Volume" id="141" />
-      <Map s="V_int_coldesc" id="142" />
-      <Map s="Organism|LargeIntestine|Mucosa|ColonSigmoid|Interstitial|Volume" id="143" />
-      <Map s="V_int_colsigm" id="144" />
-      <Map s="Organism|LargeIntestine|Mucosa|ColonTransversum|Interstitial|Volume" id="145" />
-      <Map s="V_int_coltrans" id="146" />
-      <Map s="Organism|LargeIntestine|Mucosa|Rectum|Interstitial|Volume" id="147" />
-      <Map s="V_int_rect" id="148" />
-      <Map s="Organism|LargeIntestine|Intracellular|Volume" id="149" />
-      <Map s="V_cell" id="150" />
-      <Map s="Organism|LargeIntestine|Mucosa|Caecum|Intracellular|Volume" id="151" />
-      <Map s="V_cell_cae" id="152" />
-      <Map s="Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|Volume" id="153" />
-      <Map s="V_cell_colasc" id="154" />
-      <Map s="Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|Volume" id="155" />
-      <Map s="V_cell_coldesc" id="156" />
-      <Map s="Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|Volume" id="157" />
-      <Map s="V_cell_colsigm" id="158" />
-      <Map s="Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|Volume" id="159" />
-      <Map s="V_cell_coltrans" id="160" />
-      <Map s="Organism|LargeIntestine|Mucosa|Rectum|Intracellular|Volume" id="161" />
-      <Map s="V_cell_rect" id="162" />
-      <Map s="Organism|LargeIntestine|Intracellular|MOLECULE" id="163" />
-      <Map s="M_cell" id="164" />
-      <Map s="Organism|LargeIntestine|Mucosa|Caecum|Intracellular|MOLECULE" id="165" />
-      <Map s="M_cell_cae" id="166" />
-      <Map s="Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|MOLECULE" id="167" />
-      <Map s="M_cell_colasc" id="168" />
-      <Map s="Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|MOLECULE" id="169" />
-      <Map s="M_cell_coldesc" id="170" />
-      <Map s="Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|MOLECULE" id="171" />
-      <Map s="M_cell_colsigm" id="172" />
-      <Map s="Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|MOLECULE" id="173" />
-      <Map s="M_cell_coltrans" id="174" />
-      <Map s="Organism|LargeIntestine|Mucosa|Rectum|Intracellular|MOLECULE" id="175" />
-      <Map s="M_cell_rect" id="176" />
-      <Map s="Organism|LargeIntestine|Interstitial|MOLECULE" id="177" />
-      <Map s="M_int" id="178" />
-      <Map s="Organism|LargeIntestine|Mucosa|Caecum|Interstitial|MOLECULE" id="179" />
-      <Map s="M_int_cae" id="180" />
-      <Map s="Organism|LargeIntestine|Mucosa|ColonAscendens|Interstitial|MOLECULE" id="181" />
-      <Map s="M_int_colasc" id="182" />
-      <Map s="Organism|LargeIntestine|Mucosa|ColonDescendens|Interstitial|MOLECULE" id="183" />
-      <Map s="M_int_coldesc" id="184" />
-      <Map s="Organism|LargeIntestine|Mucosa|ColonSigmoid|Interstitial|MOLECULE" id="185" />
-      <Map s="M_int_colsigm" id="186" />
-      <Map s="Organism|LargeIntestine|Mucosa|ColonTransversum|Interstitial|MOLECULE" id="187" />
-      <Map s="M_int_coltrans" id="188" />
-      <Map s="Organism|LargeIntestine|Mucosa|Rectum|Interstitial|MOLECULE" id="189" />
-      <Map s="M_int_rect" id="190" />
-      <Map s="Organism|SmallIntestine|Interstitial|Volume" id="191" />
-      <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Interstitial|Volume" id="192" />
-      <Map s="V_int_duo" id="193" />
-      <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Interstitial|Volume" id="194" />
-      <Map s="V_int_lil" id="195" />
-      <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Interstitial|Volume" id="196" />
-      <Map s="V_int_lje" id="197" />
-      <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Interstitial|Volume" id="198" />
-      <Map s="V_int_uil" id="199" />
-      <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Interstitial|Volume" id="200" />
-      <Map s="V_int_uje" id="201" />
-      <Map s="Organism|SmallIntestine|Intracellular|Volume" id="202" />
-      <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|Volume" id="203" />
-      <Map s="V_cell_duo" id="204" />
-      <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|Volume" id="205" />
-      <Map s="V_cell_lil" id="206" />
-      <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|Volume" id="207" />
-      <Map s="V_cell_lje" id="208" />
-      <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|Volume" id="209" />
-      <Map s="V_cell_uil" id="210" />
-      <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|Volume" id="211" />
-      <Map s="V_cell_uje" id="212" />
-      <Map s="Organism|SmallIntestine|Intracellular|MOLECULE" id="213" />
-      <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|MOLECULE" id="214" />
-      <Map s="M_cell_duo" id="215" />
-      <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|MOLECULE" id="216" />
-      <Map s="M_cell_lil" id="217" />
-      <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|MOLECULE" id="218" />
-      <Map s="M_cell_lje" id="219" />
-      <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|MOLECULE" id="220" />
-      <Map s="M_cell_uil" id="221" />
-      <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|MOLECULE" id="222" />
-      <Map s="M_cell_uje" id="223" />
-      <Map s="Organism|SmallIntestine|Interstitial|MOLECULE" id="224" />
-      <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Interstitial|MOLECULE" id="225" />
-      <Map s="M_int_duo" id="226" />
-      <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Interstitial|MOLECULE" id="227" />
-      <Map s="M_int_lil" id="228" />
-      <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Interstitial|MOLECULE" id="229" />
-      <Map s="M_int_lje" id="230" />
-      <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Interstitial|MOLECULE" id="231" />
-      <Map s="M_int_uil" id="232" />
-      <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Interstitial|MOLECULE" id="233" />
-      <Map s="M_int_uje" id="234" />
-      <Map s="..|..|BloodCells|MOLECULE|Concentration" id="235" />
-      <Map s="C_bc" id="236" />
-      <Map s="..|..|Plasma|MOLECULE|Concentration" id="237" />
-      <Map s="Organism|Hematocrit" id="238" />
-      <Map s="HCT" id="239" />
-      <Map s="MOLECULE|Total drug mass" id="240" />
-      <Map s="TotalDrugMass" id="241" />
+      <Map s="..|Concentration" id="22" />
+      <Map s="Concentration" id="23" />
+      <Map s="Organism|Liver|Pericentral|BloodCells|Volume" id="24" />
+      <Map s="V_bc_prc" id="25" />
+      <Map s="Volume" id="26" />
+      <Map s="Organism|Liver|Periportal|BloodCells|Volume" id="27" />
+      <Map s="V_bc_prp" id="28" />
+      <Map s="Organism|Liver|Pericentral|BloodCells|MOLECULE|Concentration" id="29" />
+      <Map s="C_bc_prc" id="30" />
+      <Map s="Organism|Liver|Periportal|BloodCells|MOLECULE|Concentration" id="31" />
+      <Map s="C_bc_prp" id="32" />
+      <Map s="Organism|Liver|Pericentral|Interstitial|Volume" id="33" />
+      <Map s="V_int_prc" id="34" />
+      <Map s="Organism|Liver|Periportal|Interstitial|Volume" id="35" />
+      <Map s="V_int_prp" id="36" />
+      <Map s="Organism|Liver|Pericentral|Interstitial|MOLECULE|Concentration" id="37" />
+      <Map s="C_int_prc" id="38" />
+      <Map s="Organism|Liver|Periportal|Interstitial|MOLECULE|Concentration" id="39" />
+      <Map s="C_int_prp" id="40" />
+      <Map s="Organism|Liver|Pericentral|Intracellular|Volume" id="41" />
+      <Map s="V_cell_prc" id="42" />
+      <Map s="Organism|Liver|Periportal|Intracellular|Volume" id="43" />
+      <Map s="V_cell_prp" id="44" />
+      <Map s="Organism|Liver|Pericentral|Intracellular|MOLECULE|Concentration" id="45" />
+      <Map s="C_cell_prc" id="46" />
+      <Map s="Organism|Liver|Periportal|Intracellular|MOLECULE|Concentration" id="47" />
+      <Map s="C_cell_prp" id="48" />
+      <Map s="Organism|Liver|Pericentral|Plasma|Volume" id="49" />
+      <Map s="V_pls_prc" id="50" />
+      <Map s="Organism|Liver|Periportal|Plasma|Volume" id="51" />
+      <Map s="V_pls_prp" id="52" />
+      <Map s="Organism|Liver|Pericentral|Plasma|MOLECULE|Concentration" id="53" />
+      <Map s="C_pls_prc" id="54" />
+      <Map s="Organism|Liver|Periportal|Plasma|MOLECULE|Concentration" id="55" />
+      <Map s="C_pls_prp" id="56" />
+      <Map s="..|Effective concentration in lumen" id="57" />
+      <Map s="EffectiveLumenConcentration" id="58" />
+      <Map s="Organism|Lumen|Caecum|MOLECULE" id="59" />
+      <Map s="M_cae" id="60" />
+      <Map s="Amount" id="61" />
+      <Map s="Organism|Lumen|ColonAscendens|MOLECULE" id="62" />
+      <Map s="M_colasc" id="63" />
+      <Map s="Organism|Lumen|ColonDescendens|MOLECULE" id="64" />
+      <Map s="M_coldesc" id="65" />
+      <Map s="Organism|Lumen|ColonSigmoid|MOLECULE" id="66" />
+      <Map s="M_colsigm" id="67" />
+      <Map s="Organism|Lumen|ColonTransversum|MOLECULE" id="68" />
+      <Map s="M_coltrans" id="69" />
+      <Map s="Organism|Lumen|Duodenum|MOLECULE" id="70" />
+      <Map s="M_duo" id="71" />
+      <Map s="Organism|Lumen|Feces|MOLECULE" id="72" />
+      <Map s="M_fec" id="73" />
+      <Map s="Organism|Lumen|LowerIleum|MOLECULE" id="74" />
+      <Map s="M_lil" id="75" />
+      <Map s="Organism|Lumen|LowerJejunum|MOLECULE" id="76" />
+      <Map s="M_lje" id="77" />
+      <Map s="Organism|Lumen|Rectum|MOLECULE" id="78" />
+      <Map s="M_rect" id="79" />
+      <Map s="Organism|Lumen|Stomach|MOLECULE" id="80" />
+      <Map s="M_sto" id="81" />
+      <Map s="Organism|Lumen|UpperIleum|MOLECULE" id="82" />
+      <Map s="M_uil" id="83" />
+      <Map s="Organism|Lumen|UpperJejunum|MOLECULE" id="84" />
+      <Map s="M_uje" id="85" />
+      <Map s="Neighborhoods|Lumen_sto_Lumen_duo|MOLECULE|Oral mass absorbed" id="86" />
+      <Map s="Mabs_Mucosa" id="87" />
+      <Map s="MOLECULE|Total oral drug mass" id="88" />
+      <Map s="TotalOralDrugMass" id="89" />
+      <Map s="MassAbsorbed" id="90" />
+      <Map s="OralDrugMass" id="91" />
+      <Map s="..|Oral mass absorbed segment" id="92" />
+      <Map s="..|..|Interstitial|MOLECULE|Concentration" id="93" />
+      <Map s="C_int" id="94" />
+      <Map s="..|..|Interstitial|MOLECULE|Partition coefficient (water/container)" id="95" />
+      <Map s="K_water_int" id="96" />
+      <Map s="Organism|Liver|Pericentral|Interstitial|MOLECULE|Partition coefficient (water/container)" id="97" />
+      <Map s="K_water_int_prc" id="98" />
+      <Map s="Organism|Liver|Periportal|Interstitial|MOLECULE|Partition coefficient (water/container)" id="99" />
+      <Map s="K_water_int_prp" id="100" />
+      <Map s="..|..|Intracellular|MOLECULE|Concentration" id="101" />
+      <Map s="C_cell" id="102" />
+      <Map s="..|..|Intracellular|MOLECULE|Partition coefficient (water/container)" id="103" />
+      <Map s="K_water_cell" id="104" />
+      <Map s="Organism|Liver|Pericentral|Intracellular|MOLECULE|Partition coefficient (water/container)" id="105" />
+      <Map s="K_water_cell_prc" id="106" />
+      <Map s="Organism|Liver|Periportal|Intracellular|MOLECULE|Partition coefficient (water/container)" id="107" />
+      <Map s="K_water_cell_prp" id="108" />
+      <Map s="Organism|ArterialBlood|Plasma|MOLECULE|Concentration" id="109" />
+      <Map s="C_pls_art" id="110" />
+      <Map s="Organism|Bone|Plasma|MOLECULE|Concentration" id="111" />
+      <Map s="C_pls_bon" id="112" />
+      <Map s="Organism|Fat|Plasma|MOLECULE|Concentration" id="113" />
+      <Map s="C_pls_fat" id="114" />
+      <Map s="Organism|Muscle|Plasma|MOLECULE|Concentration" id="115" />
+      <Map s="C_pls_mus" id="116" />
+      <Map s="Organism|Skin|Plasma|MOLECULE|Concentration" id="117" />
+      <Map s="C_pls_skn" id="118" />
+      <Map s="C_pls" id="119" />
+      <Map s="MOLECULE|Fraction unbound (plasma)" id="120" />
+      <Map s="fu" id="121" />
+      <Map s="..|..|Fraction interstitial" id="122" />
+      <Map s="f_int" id="123" />
+      <Map s="..|..|Fraction intracellular" id="124" />
+      <Map s="f_cell" id="125" />
+      <Map s="Organism|LargeIntestine|Interstitial|Volume" id="126" />
+      <Map s="V_int" id="127" />
+      <Map s="Organism|LargeIntestine|Mucosa|Caecum|Interstitial|Volume" id="128" />
+      <Map s="V_int_cae" id="129" />
+      <Map s="Organism|LargeIntestine|Mucosa|ColonAscendens|Interstitial|Volume" id="130" />
+      <Map s="V_int_colasc" id="131" />
+      <Map s="Organism|LargeIntestine|Mucosa|ColonDescendens|Interstitial|Volume" id="132" />
+      <Map s="V_int_coldesc" id="133" />
+      <Map s="Organism|LargeIntestine|Mucosa|ColonSigmoid|Interstitial|Volume" id="134" />
+      <Map s="V_int_colsigm" id="135" />
+      <Map s="Organism|LargeIntestine|Mucosa|ColonTransversum|Interstitial|Volume" id="136" />
+      <Map s="V_int_coltrans" id="137" />
+      <Map s="Organism|LargeIntestine|Mucosa|Rectum|Interstitial|Volume" id="138" />
+      <Map s="V_int_rect" id="139" />
+      <Map s="Organism|LargeIntestine|Intracellular|Volume" id="140" />
+      <Map s="V_cell" id="141" />
+      <Map s="Organism|LargeIntestine|Mucosa|Caecum|Intracellular|Volume" id="142" />
+      <Map s="V_cell_cae" id="143" />
+      <Map s="Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|Volume" id="144" />
+      <Map s="V_cell_colasc" id="145" />
+      <Map s="Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|Volume" id="146" />
+      <Map s="V_cell_coldesc" id="147" />
+      <Map s="Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|Volume" id="148" />
+      <Map s="V_cell_colsigm" id="149" />
+      <Map s="Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|Volume" id="150" />
+      <Map s="V_cell_coltrans" id="151" />
+      <Map s="Organism|LargeIntestine|Mucosa|Rectum|Intracellular|Volume" id="152" />
+      <Map s="V_cell_rect" id="153" />
+      <Map s="Organism|LargeIntestine|Intracellular|MOLECULE" id="154" />
+      <Map s="M_cell" id="155" />
+      <Map s="Organism|LargeIntestine|Mucosa|Caecum|Intracellular|MOLECULE" id="156" />
+      <Map s="M_cell_cae" id="157" />
+      <Map s="Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|MOLECULE" id="158" />
+      <Map s="M_cell_colasc" id="159" />
+      <Map s="Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|MOLECULE" id="160" />
+      <Map s="M_cell_coldesc" id="161" />
+      <Map s="Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|MOLECULE" id="162" />
+      <Map s="M_cell_colsigm" id="163" />
+      <Map s="Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|MOLECULE" id="164" />
+      <Map s="M_cell_coltrans" id="165" />
+      <Map s="Organism|LargeIntestine|Mucosa|Rectum|Intracellular|MOLECULE" id="166" />
+      <Map s="M_cell_rect" id="167" />
+      <Map s="Organism|LargeIntestine|Interstitial|MOLECULE" id="168" />
+      <Map s="M_int" id="169" />
+      <Map s="Organism|LargeIntestine|Mucosa|Caecum|Interstitial|MOLECULE" id="170" />
+      <Map s="M_int_cae" id="171" />
+      <Map s="Organism|LargeIntestine|Mucosa|ColonAscendens|Interstitial|MOLECULE" id="172" />
+      <Map s="M_int_colasc" id="173" />
+      <Map s="Organism|LargeIntestine|Mucosa|ColonDescendens|Interstitial|MOLECULE" id="174" />
+      <Map s="M_int_coldesc" id="175" />
+      <Map s="Organism|LargeIntestine|Mucosa|ColonSigmoid|Interstitial|MOLECULE" id="176" />
+      <Map s="M_int_colsigm" id="177" />
+      <Map s="Organism|LargeIntestine|Mucosa|ColonTransversum|Interstitial|MOLECULE" id="178" />
+      <Map s="M_int_coltrans" id="179" />
+      <Map s="Organism|LargeIntestine|Mucosa|Rectum|Interstitial|MOLECULE" id="180" />
+      <Map s="M_int_rect" id="181" />
+      <Map s="Organism|SmallIntestine|Interstitial|Volume" id="182" />
+      <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Interstitial|Volume" id="183" />
+      <Map s="V_int_duo" id="184" />
+      <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Interstitial|Volume" id="185" />
+      <Map s="V_int_lil" id="186" />
+      <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Interstitial|Volume" id="187" />
+      <Map s="V_int_lje" id="188" />
+      <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Interstitial|Volume" id="189" />
+      <Map s="V_int_uil" id="190" />
+      <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Interstitial|Volume" id="191" />
+      <Map s="V_int_uje" id="192" />
+      <Map s="Organism|SmallIntestine|Intracellular|Volume" id="193" />
+      <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|Volume" id="194" />
+      <Map s="V_cell_duo" id="195" />
+      <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|Volume" id="196" />
+      <Map s="V_cell_lil" id="197" />
+      <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|Volume" id="198" />
+      <Map s="V_cell_lje" id="199" />
+      <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|Volume" id="200" />
+      <Map s="V_cell_uil" id="201" />
+      <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|Volume" id="202" />
+      <Map s="V_cell_uje" id="203" />
+      <Map s="Organism|SmallIntestine|Intracellular|MOLECULE" id="204" />
+      <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|MOLECULE" id="205" />
+      <Map s="M_cell_duo" id="206" />
+      <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|MOLECULE" id="207" />
+      <Map s="M_cell_lil" id="208" />
+      <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|MOLECULE" id="209" />
+      <Map s="M_cell_lje" id="210" />
+      <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|MOLECULE" id="211" />
+      <Map s="M_cell_uil" id="212" />
+      <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|MOLECULE" id="213" />
+      <Map s="M_cell_uje" id="214" />
+      <Map s="Organism|SmallIntestine|Interstitial|MOLECULE" id="215" />
+      <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Interstitial|MOLECULE" id="216" />
+      <Map s="M_int_duo" id="217" />
+      <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Interstitial|MOLECULE" id="218" />
+      <Map s="M_int_lil" id="219" />
+      <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Interstitial|MOLECULE" id="220" />
+      <Map s="M_int_lje" id="221" />
+      <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Interstitial|MOLECULE" id="222" />
+      <Map s="M_int_uil" id="223" />
+      <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Interstitial|MOLECULE" id="224" />
+      <Map s="M_int_uje" id="225" />
+      <Map s="..|..|BloodCells|MOLECULE|Concentration" id="226" />
+      <Map s="C_bc" id="227" />
+      <Map s="..|..|Plasma|MOLECULE|Concentration" id="228" />
+      <Map s="Organism|Hematocrit" id="229" />
+      <Map s="HCT" id="230" />
+      <Map s=".." id="231" />
+      <Map s="M" id="232" />
+      <Map s="MOLECULE|Total drug mass" id="233" />
+      <Map s="TotalDrugMass" id="234" />
     </StringMap>
   </FormulaCache>
 </ObserverBuildingBlock>
\ No newline at end of file
diff --git a/src/Data/Templates/Standard Passive Transports.pkml b/src/Data/Templates/Standard Passive Transports.pkml
index 53486a12d..aaefe74f8 100644
--- a/src/Data/Templates/Standard Passive Transports.pkml	
+++ b/src/Data/Templates/Standard Passive Transports.pkml	
@@ -1,8 +1,8 @@
 <?xml version="1.0" encoding="utf-8"?>
-<PassiveTransportBuildingBlock id="PoBrXU4U6ES5NqjqG1XTsg" name="Standard Passive Transports" icon="PassiveTransport" bbVersion="0" version="13">
-  <Creation createdAt="5248308555518922008" createdBy="EZZJY" creationMode="New" origin="PKSim" version="7.3.0" internalVersion="74" />
+<PassiveTransportBuildingBlock id="Wpvx3QeDgE2BL8d-4y3pZA" name="Standard Passive Transports" icon="PassiveTransport" bbVersion="0" version="14">
+  <Creation createdAt="5248852327625094285" createdBy="Michael" creationMode="New" origin="PKSim" version="9.0" internalVersion="77" />
   <Builders>
-    <TransportBuilder id="4MXDjWorXEuA3o91IZuqoA" name="DrugAbsorption_para" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="1" processRateParameterPersistable="0" formula="C6sp_v55Nk-mGZbPEP46hQ" transportType="0">
+    <TransportBuilder id="jTZCAB2v0USj_5yuxS1wDQ" name="DrugAbsorption_para" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="1" processRateParameterPersistable="0" formula="YQ8oNCIeXEWJnJmCaMRtQw" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="Lumen" />
@@ -17,7 +17,7 @@
       </TargetCriteria>
       <MoleculeList forAll="1" />
     </TransportBuilder>
-    <TransportBuilder id="Lr0ySl2eBkeoZWKtUUoodw" name="DrugAbsorption_trans" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="1" processRateParameterPersistable="0" formula="nhYIDOMSPk-VNJJwQ1lBIA" transportType="0">
+    <TransportBuilder id="8QcosnUh4kiIb2e-pUD0lw" name="DrugAbsorption_trans" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="1" processRateParameterPersistable="0" formula="QFrL1YxtmkqXXtDkcCXNGQ" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <NotMatchTagCondition tag="Feces" />
@@ -32,7 +32,7 @@
       </TargetCriteria>
       <MoleculeList forAll="1" />
     </TransportBuilder>
-    <TransportBuilder id="4hRtzTkvdkOnv5njq8gA5w" name="LumenDrugTransport_cae" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="RWJ3soL2e02xotxx3DerOg" transportType="0">
+    <TransportBuilder id="FcAZxOY9KE6unwzVVFvC2Q" name="LumenDrugTransport_cae" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="OY4N94OZsEineRcrLbasww" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="LowerIleum" />
@@ -47,7 +47,7 @@
       </TargetCriteria>
       <MoleculeList forAll="1" />
     </TransportBuilder>
-    <TransportBuilder id="Hm5c5sLd9USJtNDzK5HONg" name="LumenDrugTransport_colasc" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="RWJ3soL2e02xotxx3DerOg" transportType="0">
+    <TransportBuilder id="8tiob2m79UeRtFj4mGDJ1Q" name="LumenDrugTransport_colasc" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="OY4N94OZsEineRcrLbasww" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="Caecum" />
@@ -62,7 +62,7 @@
       </TargetCriteria>
       <MoleculeList forAll="1" />
     </TransportBuilder>
-    <TransportBuilder id="Nyr88an36kqyCd8mF77CHg" name="LumenDrugTransport_coldesc" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="RWJ3soL2e02xotxx3DerOg" transportType="0">
+    <TransportBuilder id="xwgjfYPqrUSO7EaWBY_QPA" name="LumenDrugTransport_coldesc" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="OY4N94OZsEineRcrLbasww" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="ColonTransversum" />
@@ -77,7 +77,7 @@
       </TargetCriteria>
       <MoleculeList forAll="1" />
     </TransportBuilder>
-    <TransportBuilder id="vU2X1sCfiEajtQ1LqhTMuQ" name="LumenDrugTransport_colsigm" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="RWJ3soL2e02xotxx3DerOg" transportType="0">
+    <TransportBuilder id="Rw6GKSqGjEqsEYueagMNTg" name="LumenDrugTransport_colsigm" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="OY4N94OZsEineRcrLbasww" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="ColonDescendens" />
@@ -92,7 +92,7 @@
       </TargetCriteria>
       <MoleculeList forAll="1" />
     </TransportBuilder>
-    <TransportBuilder id="GcsRSrB-xkyzpqENLk4AOw" name="LumenDrugTransport_coltrans" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="RWJ3soL2e02xotxx3DerOg" transportType="0">
+    <TransportBuilder id="uE7BTHuq9UmDWdlxxeEMeg" name="LumenDrugTransport_coltrans" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="OY4N94OZsEineRcrLbasww" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="ColonAscendens" />
@@ -107,7 +107,7 @@
       </TargetCriteria>
       <MoleculeList forAll="1" />
     </TransportBuilder>
-    <TransportBuilder id="_0qfw-hrxUm282FPQW8Yrg" name="LumenDrugTransport_duo" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="RWJ3soL2e02xotxx3DerOg" transportType="0">
+    <TransportBuilder id="cVoSgCuMkUCYIsesE2bacg" name="LumenDrugTransport_duo" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="OY4N94OZsEineRcrLbasww" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="Lumen" />
@@ -122,7 +122,7 @@
       </TargetCriteria>
       <MoleculeList forAll="1" />
     </TransportBuilder>
-    <TransportBuilder id="Yr9lhKzVP02liWNU00L_gQ" name="LumenDrugTransport_fec" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="XTIz1G5HjEyJWkI-BjDc-Q" transportType="0">
+    <TransportBuilder id="VBknut6GxkuHQdSSAkRkhQ" name="LumenDrugTransport_fec" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="kmhZC3HY0kmohXKkRH03ag" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="Lumen" />
@@ -137,7 +137,7 @@
       </TargetCriteria>
       <MoleculeList forAll="1" />
     </TransportBuilder>
-    <TransportBuilder id="IZxW0L5wi0i-Fa-PjbJwCw" name="LumenDrugTransport_lil" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="RWJ3soL2e02xotxx3DerOg" transportType="0">
+    <TransportBuilder id="vxK6t0VXU0CNMy3qHhqBWA" name="LumenDrugTransport_lil" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="OY4N94OZsEineRcrLbasww" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="Lumen" />
@@ -152,7 +152,7 @@
       </TargetCriteria>
       <MoleculeList forAll="1" />
     </TransportBuilder>
-    <TransportBuilder id="ULWiOBTl2UybAlEhg1I0bA" name="LumenDrugTransport_lje" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="RWJ3soL2e02xotxx3DerOg" transportType="0">
+    <TransportBuilder id="vEyjNZJNQkG8xIDw8e3Taw" name="LumenDrugTransport_lje" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="OY4N94OZsEineRcrLbasww" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="Lumen" />
@@ -167,7 +167,7 @@
       </TargetCriteria>
       <MoleculeList forAll="1" />
     </TransportBuilder>
-    <TransportBuilder id="o4bjkV7aZkSVxKw1rJbRtg" name="LumenDrugTransport_rect" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="RWJ3soL2e02xotxx3DerOg" transportType="0">
+    <TransportBuilder id="xC9XY0Oj6UW0KKR5N2-BpQ" name="LumenDrugTransport_rect" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="OY4N94OZsEineRcrLbasww" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="ColonSigmoid" />
@@ -182,7 +182,7 @@
       </TargetCriteria>
       <MoleculeList forAll="1" />
     </TransportBuilder>
-    <TransportBuilder id="liMLv1SvqESYxYQ1WV1XCw" name="LumenDrugTransport_uil" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="RWJ3soL2e02xotxx3DerOg" transportType="0">
+    <TransportBuilder id="YGXk62xN1kWOdewqwtYaLQ" name="LumenDrugTransport_uil" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="OY4N94OZsEineRcrLbasww" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="LowerJejunum" />
@@ -197,7 +197,7 @@
       </TargetCriteria>
       <MoleculeList forAll="1" />
     </TransportBuilder>
-    <TransportBuilder id="YcPhqrP8D0OKJvlqEM16gw" name="LumenDrugTransport_uje" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="RWJ3soL2e02xotxx3DerOg" transportType="0">
+    <TransportBuilder id="WWzKQXzFF0qOhvhRQ7F57w" name="LumenDrugTransport_uje" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="OY4N94OZsEineRcrLbasww" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="Duodenum" />
@@ -212,41 +212,7 @@
       </TargetCriteria>
       <MoleculeList forAll="1" />
     </TransportBuilder>
-    <TransportBuilder id="b38NleNJ4UaBs_R8FGTz0Q" name="MassTransfer_PeriportalToPericentral_BC" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="jdIkQXUjBkW1PZEvdqkRHA" transportType="0">
-      <SourceCriteria>
-        <DescriptorConditions>
-          <MatchTagCondition tag="BloodCells" />
-          <MatchTagCondition tag="Liver" />
-          <MatchTagCondition tag="Periportal" />
-        </DescriptorConditions>
-      </SourceCriteria>
-      <TargetCriteria>
-        <DescriptorConditions>
-          <MatchTagCondition tag="BloodCells" />
-          <MatchTagCondition tag="Liver" />
-          <MatchTagCondition tag="Pericentral" />
-        </DescriptorConditions>
-      </TargetCriteria>
-      <MoleculeList forAll="1" />
-    </TransportBuilder>
-    <TransportBuilder id="OSeeYCrkTESHSPb202sChA" name="MassTransfer_PeriportalToPericentral_Plasma" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="U04MRgImN0KZG9cTpq7msQ" transportType="0">
-      <SourceCriteria>
-        <DescriptorConditions>
-          <MatchTagCondition tag="Liver" />
-          <MatchTagCondition tag="Periportal" />
-          <MatchTagCondition tag="Plasma" />
-        </DescriptorConditions>
-      </SourceCriteria>
-      <TargetCriteria>
-        <DescriptorConditions>
-          <MatchTagCondition tag="Liver" />
-          <MatchTagCondition tag="Pericentral" />
-          <MatchTagCondition tag="Plasma" />
-        </DescriptorConditions>
-      </TargetCriteria>
-      <MoleculeList forAll="1" />
-    </TransportBuilder>
-    <TransportBuilder id="D6UuCwHW9Eaa9R-v5ARu_g" name="MassTransferBloodPool2OrgPl" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="Y10Xjt4dh0ubhC1Xog2Oig" transportType="0">
+    <TransportBuilder id="H4nYrjuw5kaEVB7ER-UhSA" name="MassTransferBloodPool2OrgPl" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="yI3_kGM0VEiluXC7Fx9OVQ" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="ArterialBlood" />
@@ -262,7 +228,7 @@
       </TargetCriteria>
       <MoleculeList forAll="1" />
     </TransportBuilder>
-    <TransportBuilder id="r1hNJIZWRkq3Fxfte1HpsQ" name="MassTransferBloodPool2OrgPl_liv" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="-FxcEYfqrEa6X8xgicVhZw" transportType="0">
+    <TransportBuilder id="3Qz-NcoAnUq50ShmOgt-tA" name="MassTransferBloodPool2OrgPl_liv" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="FqqH6QMGZkySSDAVip_wQA" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="Plasma" />
@@ -277,7 +243,7 @@
       </TargetCriteria>
       <MoleculeList forAll="1" />
     </TransportBuilder>
-    <TransportBuilder id="D27iWPL_qE6p93JsB2Ejcg" name="MassTransferBloodPool2OrgPl_lng" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="TnD-d_6iYUuedWCGR8j9Og" transportType="0">
+    <TransportBuilder id="_-dUFGH4XkOK06hDuOOJKQ" name="MassTransferBloodPool2OrgPl_lng" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="ZosLRCL7m0yJ8Tdw1lnwxQ" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="Plasma" />
@@ -292,7 +258,7 @@
       </TargetCriteria>
       <MoleculeList forAll="1" />
     </TransportBuilder>
-    <TransportBuilder id="Nxvf8U704kqiV5jeQTKKqg" name="MassTransferBloodPool2OrgRBC" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="BbjH60Y1DUqibmx3K3VKXw" transportType="0">
+    <TransportBuilder id="7vq78BGEiUGRldM3ts5nPA" name="MassTransferBloodPool2OrgRBC" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="1xopEa38v0uYsfAO4rcpUg" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="ArterialBlood" />
@@ -308,7 +274,7 @@
       </TargetCriteria>
       <MoleculeList forAll="1" />
     </TransportBuilder>
-    <TransportBuilder id="Uy86-PvB7Um5pW6aQjoqrw" name="MassTransferBloodPool2OrgRBC_liv" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="XTgxVyjD6Ui11ybRKajDWg" transportType="0">
+    <TransportBuilder id="oaBSxMJyrkKxvYdf3cubKA" name="MassTransferBloodPool2OrgRBC_liv" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="r46P9x5-YUG-u6CmBBi0lg" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="BloodCells" />
@@ -323,7 +289,7 @@
       </TargetCriteria>
       <MoleculeList forAll="1" />
     </TransportBuilder>
-    <TransportBuilder id="g5zKGzqOvkK85H3FO54eoQ" name="MassTransferBloodPool2OrgRBC_lng" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="BB62HuXiQUqx3__Xap7VVw" transportType="0">
+    <TransportBuilder id="HZaKhosS_k6BCGXpkofBzA" name="MassTransferBloodPool2OrgRBC_lng" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="sLmvPrc-sUCVloSXfdw_VQ" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="BloodCells" />
@@ -338,71 +304,71 @@
       </TargetCriteria>
       <MoleculeList forAll="1" />
     </TransportBuilder>
-    <TransportBuilder id="dniltsGshUCrrKbelEz7Yw" name="MassTransferLinPlasma2BloodPool_Pve" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="v050G1l2c0GDIlqkbH2CSw" transportType="0">
+    <TransportBuilder id="D-teAVs2l0iSHFdxZ-q5GQ" name="MassTransferLINToMucosaBC" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="dtAJKYRvzkShuOKuVmykqg" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
+          <MatchTagCondition tag="BloodCells" />
           <MatchTagCondition tag="LargeIntestine" />
           <NotMatchTagCondition tag="Mucosa" />
-          <MatchTagCondition tag="Plasma" />
         </DescriptorConditions>
       </SourceCriteria>
       <TargetCriteria>
         <DescriptorConditions>
-          <MatchTagCondition tag="Plasma" />
-          <MatchTagCondition tag="PortalVein" />
+          <MatchTagCondition tag="BloodCells" />
+          <MatchTagCondition tag="Mucosa" />
         </DescriptorConditions>
       </TargetCriteria>
       <MoleculeList forAll="1" />
     </TransportBuilder>
-    <TransportBuilder id="SiORNT3owUetcDWBKF8_gQ" name="MassTransferLinRBC2BloodPool_Pve" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="-K_rpC6I6U-WhC90rThnQQ" transportType="0">
+    <TransportBuilder id="9AuELsjwZUus2zi4uc27Iw" name="MassTransferLINToMucosaPlasma" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="lq474X_Cn0SeIjd4tJrMFQ" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
-          <MatchTagCondition tag="BloodCells" />
           <MatchTagCondition tag="LargeIntestine" />
           <NotMatchTagCondition tag="Mucosa" />
+          <MatchTagCondition tag="Plasma" />
         </DescriptorConditions>
       </SourceCriteria>
       <TargetCriteria>
         <DescriptorConditions>
-          <MatchTagCondition tag="BloodCells" />
-          <MatchTagCondition tag="PortalVein" />
+          <MatchTagCondition tag="Mucosa" />
+          <MatchTagCondition tag="Plasma" />
         </DescriptorConditions>
       </TargetCriteria>
       <MoleculeList forAll="1" />
     </TransportBuilder>
-    <TransportBuilder id="9hz6OSaJWEigKheiNE0PMQ" name="MassTransferLINToMucosaBC" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="18a7-kn5n0ifl2dklhTYuA" transportType="0">
+    <TransportBuilder id="ViQ7NeivSkiSwmw8hRKPaA" name="MassTransferLinPlasma2BloodPool_Pve" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="-tpUBKGM30mnFtj-GF0dWQ" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
-          <MatchTagCondition tag="BloodCells" />
           <MatchTagCondition tag="LargeIntestine" />
           <NotMatchTagCondition tag="Mucosa" />
+          <MatchTagCondition tag="Plasma" />
         </DescriptorConditions>
       </SourceCriteria>
       <TargetCriteria>
         <DescriptorConditions>
-          <MatchTagCondition tag="BloodCells" />
-          <MatchTagCondition tag="Mucosa" />
+          <MatchTagCondition tag="Plasma" />
+          <MatchTagCondition tag="PortalVein" />
         </DescriptorConditions>
       </TargetCriteria>
       <MoleculeList forAll="1" />
     </TransportBuilder>
-    <TransportBuilder id="69bitpOfL0aYuZhtgi1XCw" name="MassTransferLINToMucosaPlasma" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="viF648G3CkeaN2b7RnERYA" transportType="0">
+    <TransportBuilder id="vGvBAySWy0ScFAfYBkfA9Q" name="MassTransferLinRBC2BloodPool_Pve" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="6yLx3bzNLEGAOBiBY2rUFg" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
+          <MatchTagCondition tag="BloodCells" />
           <MatchTagCondition tag="LargeIntestine" />
           <NotMatchTagCondition tag="Mucosa" />
-          <MatchTagCondition tag="Plasma" />
         </DescriptorConditions>
       </SourceCriteria>
       <TargetCriteria>
         <DescriptorConditions>
-          <MatchTagCondition tag="Mucosa" />
-          <MatchTagCondition tag="Plasma" />
+          <MatchTagCondition tag="BloodCells" />
+          <MatchTagCondition tag="PortalVein" />
         </DescriptorConditions>
       </TargetCriteria>
       <MoleculeList forAll="1" />
     </TransportBuilder>
-    <TransportBuilder id="asolub18bkW6uLKvkGcqnw" name="MassTransferMucosaToPveBC" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="5SxPX-ZeS0W4-yjBHq3e8Q" transportType="0">
+    <TransportBuilder id="UmmMDhactECvBFvDmuChUA" name="MassTransferMucosaToPveBC" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="1Us1R6yn90G9Rr2BF9kTEQ" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="BloodCells" />
@@ -417,7 +383,7 @@
       </TargetCriteria>
       <MoleculeList forAll="1" />
     </TransportBuilder>
-    <TransportBuilder id="vMpNS2wV0EKXiY4vpDMeWA" name="MassTransferMucosaToPvePlasma" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="s0PWlofqXUevOx0bxVnciQ" transportType="0">
+    <TransportBuilder id="CwZhtAp9zUGL7MVhTwz3vQ" name="MassTransferMucosaToPvePlasma" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="gE16Gsjv6ESrKbbdppTiKg" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="Mucosa" />
@@ -432,7 +398,7 @@
       </TargetCriteria>
       <MoleculeList forAll="1" />
     </TransportBuilder>
-    <TransportBuilder id="7Y0HdZuvcEC5s_1Tn7717Q" name="MassTransferOrgPl2BloodPool" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="69TdNTvo_U6kz3FGf4V3og" transportType="0">
+    <TransportBuilder id="qjT04yUhcE6SX9vfuJRtSA" name="MassTransferOrgPl2BloodPool" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="ky7WYH9ymEK2YdzJhHI8YA" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <NotMatchTagCondition tag="Liver" />
@@ -449,7 +415,7 @@
       </TargetCriteria>
       <MoleculeList forAll="1" />
     </TransportBuilder>
-    <TransportBuilder id="5Ms2F_LMYkOwkR6V2qodpQ" name="MassTransferOrgPl2BloodPool_Liv" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="cVjXgI7DOEa1ncXoGyJKzw" transportType="0">
+    <TransportBuilder id="5YXjyPJRrECEhgYjHuCSlQ" name="MassTransferOrgPl2BloodPool_Liv" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="Ci3yFMPZd0iktOoM8TRc_g" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="Liver" />
@@ -465,7 +431,7 @@
       </TargetCriteria>
       <MoleculeList forAll="1" />
     </TransportBuilder>
-    <TransportBuilder id="4ZtjGs6LEkKOpzI84_OZ6w" name="MassTransferOrgPl2BloodPool_Liv_Pericentral" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="JyHO4GNUFECLeACVTvKGcQ" transportType="0">
+    <TransportBuilder id="qPXVWmQZsUuaoWj6xHxzQg" name="MassTransferOrgPl2BloodPool_Liv_Pericentral" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="-i7bB9QENE2uGszRc4_SRg" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="Liver" />
@@ -481,7 +447,7 @@
       </TargetCriteria>
       <MoleculeList forAll="1" />
     </TransportBuilder>
-    <TransportBuilder id="rPzb_kTcCk6oTyzA1H82FQ" name="MassTransferOrgPl2BloodPool_Lng" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="7CZ6L6_CbE6iasiuCBxI5w" transportType="0">
+    <TransportBuilder id="wjlfB5v9FU-1Vt0TArBLyg" name="MassTransferOrgPl2BloodPool_Lng" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="4MvIF1cPgUmzDJ2zbgRUJQ" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="Lung" />
@@ -496,7 +462,7 @@
       </TargetCriteria>
       <MoleculeList forAll="1" />
     </TransportBuilder>
-    <TransportBuilder id="aEnrWXbA1kGp-WfgVqyAbg" name="MassTransferOrgPl2BloodPool_pve" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="QoKRrSK8WEmTsiLhtsZvhg" transportType="0">
+    <TransportBuilder id="l04OFkw8hkaxXpa-12a_IQ" name="MassTransferOrgPl2BloodPool_pve" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="HDpkpI7cH0uTF_yj5G54qA" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <NotMatchTagCondition tag="LargeIntestine" />
@@ -514,7 +480,7 @@
       </TargetCriteria>
       <MoleculeList forAll="1" />
     </TransportBuilder>
-    <TransportBuilder id="Zzvb-JLLdEOiTnkcAy8LSA" name="MassTransferOrgRBC2BloodPool" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="l1jWjcGD-0uIHIvLAqd5dQ" transportType="0">
+    <TransportBuilder id="G9HpcwtGikSeWe7IKDV-jA" name="MassTransferOrgRBC2BloodPool" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="VhWmLCAkG0GnN5YyF4f99w" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="BloodCells" />
@@ -531,7 +497,7 @@
       </TargetCriteria>
       <MoleculeList forAll="1" />
     </TransportBuilder>
-    <TransportBuilder id="1RL6X58VF0Ct1gLgBrFLXg" name="MassTransferOrgRBC2BloodPool_Liv" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="Lq5hdoNTpEWH75FhUTuFBg" transportType="0">
+    <TransportBuilder id="Uk-nDBv9OEGAM9-D3BOAnA" name="MassTransferOrgRBC2BloodPool_Liv" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="xN10-0Qtj0Scobsc1Ojj8g" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="BloodCells" />
@@ -547,7 +513,7 @@
       </TargetCriteria>
       <MoleculeList forAll="1" />
     </TransportBuilder>
-    <TransportBuilder id="iEfZAUQOqEGVcdZCx1HyIw" name="MassTransferOrgRBC2BloodPool_Liv_Pericentral" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="jAtqRpd3xUKqEjlB06dUxQ" transportType="0">
+    <TransportBuilder id="eGItcVZVIUKqkwwCXc3Qsw" name="MassTransferOrgRBC2BloodPool_Liv_Pericentral" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="YJFd7Pkhhk6qKwR44nSOMA" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="BloodCells" />
@@ -563,7 +529,7 @@
       </TargetCriteria>
       <MoleculeList forAll="1" />
     </TransportBuilder>
-    <TransportBuilder id="nvPlwY3x0USkF7nuf_ONmQ" name="MassTransferOrgRBC2BloodPool_Lng" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="m6rYoibFLkOvUG0_R0lw4A" transportType="0">
+    <TransportBuilder id="CJy6uVrz3EyAyxPApv2D4A" name="MassTransferOrgRBC2BloodPool_Lng" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="judWqvLS_kqXBu9pGLRI6Q" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="BloodCells" />
@@ -578,7 +544,7 @@
       </TargetCriteria>
       <MoleculeList forAll="1" />
     </TransportBuilder>
-    <TransportBuilder id="6y9E_FhmT0Cx7tWOU-omBw" name="MassTransferOrgRBC2BloodPool_Pve" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="ny0E4VjN6kGOeLjALjbh7g" transportType="0">
+    <TransportBuilder id="IExuhdPoyUaI-CfTGG-rGw" name="MassTransferOrgRBC2BloodPool_Pve" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="al1cphoWE0ydFX8487RBIA" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="BloodCells" />
@@ -597,7 +563,39 @@
       </TargetCriteria>
       <MoleculeList forAll="1" />
     </TransportBuilder>
-    <TransportBuilder id="Q-LGGB9uR0azJAvChICBTg" name="MassTransferSinPlasma2BloodPool_Pve" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="v050G1l2c0GDIlqkbH2CSw" transportType="0">
+    <TransportBuilder id="8WVgJuR0Dk-cM3Lxcly7DA" name="MassTransferSINToMucosaBC" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="dtAJKYRvzkShuOKuVmykqg" transportType="0">
+      <SourceCriteria>
+        <DescriptorConditions>
+          <MatchTagCondition tag="BloodCells" />
+          <NotMatchTagCondition tag="Mucosa" />
+          <MatchTagCondition tag="SmallIntestine" />
+        </DescriptorConditions>
+      </SourceCriteria>
+      <TargetCriteria>
+        <DescriptorConditions>
+          <MatchTagCondition tag="BloodCells" />
+          <MatchTagCondition tag="Mucosa" />
+        </DescriptorConditions>
+      </TargetCriteria>
+      <MoleculeList forAll="1" />
+    </TransportBuilder>
+    <TransportBuilder id="qn-91hZU-UKSgTszJ6tu6Q" name="MassTransferSINToMucosaPlasma" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="lq474X_Cn0SeIjd4tJrMFQ" transportType="0">
+      <SourceCriteria>
+        <DescriptorConditions>
+          <NotMatchTagCondition tag="Mucosa" />
+          <MatchTagCondition tag="Plasma" />
+          <MatchTagCondition tag="SmallIntestine" />
+        </DescriptorConditions>
+      </SourceCriteria>
+      <TargetCriteria>
+        <DescriptorConditions>
+          <MatchTagCondition tag="Mucosa" />
+          <MatchTagCondition tag="Plasma" />
+        </DescriptorConditions>
+      </TargetCriteria>
+      <MoleculeList forAll="1" />
+    </TransportBuilder>
+    <TransportBuilder id="ey_iqsWOkUWsiB6wJsfVZg" name="MassTransferSinPlasma2BloodPool_Pve" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="-tpUBKGM30mnFtj-GF0dWQ" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <NotMatchTagCondition tag="Mucosa" />
@@ -613,7 +611,7 @@
       </TargetCriteria>
       <MoleculeList forAll="1" />
     </TransportBuilder>
-    <TransportBuilder id="pdlAF4-ViUqxv5XcSBXyiQ" name="MassTransferSinRBC2BloodPool_Pve" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="-K_rpC6I6U-WhC90rThnQQ" transportType="0">
+    <TransportBuilder id="97H_q7NOuEuQsUu4fVxejw" name="MassTransferSinRBC2BloodPool_Pve" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="6yLx3bzNLEGAOBiBY2rUFg" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="BloodCells" />
@@ -629,39 +627,41 @@
       </TargetCriteria>
       <MoleculeList forAll="1" />
     </TransportBuilder>
-    <TransportBuilder id="689y4aBIYUeNQAWSKDH1cA" name="MassTransferSINToMucosaBC" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="18a7-kn5n0ifl2dklhTYuA" transportType="0">
+    <TransportBuilder id="GVufooOkUkuuOtcMtDN9uw" name="MassTransfer_PeriportalToPericentral_BC" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="9TMTIfAPVEmuoFZOWLRopQ" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="BloodCells" />
-          <NotMatchTagCondition tag="Mucosa" />
-          <MatchTagCondition tag="SmallIntestine" />
+          <MatchTagCondition tag="Liver" />
+          <MatchTagCondition tag="Periportal" />
         </DescriptorConditions>
       </SourceCriteria>
       <TargetCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="BloodCells" />
-          <MatchTagCondition tag="Mucosa" />
+          <MatchTagCondition tag="Liver" />
+          <MatchTagCondition tag="Pericentral" />
         </DescriptorConditions>
       </TargetCriteria>
       <MoleculeList forAll="1" />
     </TransportBuilder>
-    <TransportBuilder id="8iF1RUUOTEOl5uCxqMnvQQ" name="MassTransferSINToMucosaPlasma" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="viF648G3CkeaN2b7RnERYA" transportType="0">
+    <TransportBuilder id="b__ZiUWjjE-KNBy-FE1QBw" name="MassTransfer_PeriportalToPericentral_Plasma" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="IxEFR9qipkyx1VGW83Zqyg" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
-          <NotMatchTagCondition tag="Mucosa" />
+          <MatchTagCondition tag="Liver" />
+          <MatchTagCondition tag="Periportal" />
           <MatchTagCondition tag="Plasma" />
-          <MatchTagCondition tag="SmallIntestine" />
         </DescriptorConditions>
       </SourceCriteria>
       <TargetCriteria>
         <DescriptorConditions>
-          <MatchTagCondition tag="Mucosa" />
+          <MatchTagCondition tag="Liver" />
+          <MatchTagCondition tag="Pericentral" />
           <MatchTagCondition tag="Plasma" />
         </DescriptorConditions>
       </TargetCriteria>
       <MoleculeList forAll="1" />
     </TransportBuilder>
-    <TransportBuilder id="MS9toclIekemR9ZZkbQvmQ" name="PassiveDiffusionInt2Cell" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="kXYwzLTQ3EaZ1heAkBvo2w" transportType="0">
+    <TransportBuilder id="VFGi26oSAUyIuLuF6MxWUw" name="PassiveDiffusionInt2Cell" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="GC1XkdtgWEOkSPm7yVgtGw" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="Interstitial" />
@@ -674,7 +674,7 @@
       </TargetCriteria>
       <MoleculeList forAll="1" />
     </TransportBuilder>
-    <TransportBuilder id="VJPKwLgoKk-ho-UAdfCAKQ" name="PassiveDiffusionPl2Int" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="0fpOMWyaCEa5IoNVee9XXw" transportType="0">
+    <TransportBuilder id="sQh7Qj8a3U2lfOgU_gZB3Q" name="PassiveDiffusionPl2Int" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="CL-Y2y2R0kyJ-p69S4YgeQ" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <NotMatchTagCondition tag="ArterialBlood" />
@@ -691,7 +691,7 @@
       </TargetCriteria>
       <MoleculeList forAll="1" />
     </TransportBuilder>
-    <TransportBuilder id="_ahGwaSwmU6D9TLaUlaedw" name="PassiveDiffusionPl2RBC" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="WiLogmDBKUurwF7Q3klC0g" transportType="0">
+    <TransportBuilder id="2zBQ-Ocba0m0XREopHOkQg" name="PassiveDiffusionPl2RBC" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="VmjrE0ErB0WyJBIY7d-8Gg" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="Plasma" />
@@ -704,7 +704,7 @@
       </TargetCriteria>
       <MoleculeList forAll="1" />
     </TransportBuilder>
-    <TransportBuilder id="FFh669r8c0iKbVgcNYb5jw" name="PassiveDiffusionPlsToSaliva" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="KawN5BAaREC8eWVnNjRxNQ" transportType="0">
+    <TransportBuilder id="Zrd2etgkIEKLG6Mf7TBRug" name="PassiveDiffusionPlsToSaliva" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="rQHuihnMj0KUKH0eYUtPBQ" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="Saliva" />
@@ -719,7 +719,7 @@
       </TargetCriteria>
       <MoleculeList forAll="1" />
     </TransportBuilder>
-    <TransportBuilder id="oRelOFwSNEKM0cylnaxs_Q" name="GallbladderEmptying" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="XGeF5rtzlUKzL58UQwql4Q" transportType="0">
+    <TransportBuilder id="wIqvkyzKvUaSJYy6UPz3RQ" name="GallbladderEmptying" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="Iqph7dBe_U2weZVDV75hAA" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="Gallbladder" />
@@ -736,17 +736,17 @@
   </Builders>
   <FormulaCache>
     <Formulas>
-      <Formula id="C6sp_v55Nk-mGZbPEP46hQ" name="DrugAbsorption_para" dim="Amount per time" formula="DrugAbsorptionLumenToMucosaRate">
+      <Formula id="YQ8oNCIeXEWJnJmCaMRtQw" name="DrugAbsorption_para" dim="Amount per time" formula="DrugAbsorptionLumenToMucosaRate">
         <Paths>
           <Path path="0" as="1" dim="2" />
         </Paths>
       </Formula>
-      <Formula id="nhYIDOMSPk-VNJJwQ1lBIA" name="DrugAbsorption_trans" dim="Amount per time" formula="DrugAbsorptionLumenToMucosaRate">
+      <Formula id="QFrL1YxtmkqXXtDkcCXNGQ" name="DrugAbsorption_trans" dim="Amount per time" formula="DrugAbsorptionLumenToMucosaRate">
         <Paths>
           <Path path="0" as="1" dim="2" />
         </Paths>
       </Formula>
-      <Formula id="RWJ3soL2e02xotxx3DerOg" name="LumenDrugTransport" dim="Amount per time" formula="(OralApplicationsEnabled AND IsFloatingInLumen) ? w*Drug*FillLevelFlagNext : 0">
+      <Formula id="OY4N94OZsEineRcrLbasww" name="LumenDrugTransport" dim="Amount per time" formula="(OralApplicationsEnabled AND IsFloatingInLumen) ? w*Drug*FillLevelFlagNext : 0">
         <Paths>
           <Path path="3" as="4" />
           <Path path="5" as="6" dim="7" />
@@ -755,188 +755,188 @@
           <Path path="13" as="14" />
         </Paths>
       </Formula>
-      <Formula id="XTIz1G5HjEyJWkI-BjDc-Q" name="LumenDrugTransport_Feces" dim="Amount per time" formula="OralApplicationsEnabled ? w*Drug : 0">
+      <Formula id="kmhZC3HY0kmohXKkRH03ag" name="LumenDrugTransport_Feces" dim="Amount per time" formula="OralApplicationsEnabled ? w*Drug : 0">
         <Paths>
           <Path path="3" as="4" />
           <Path path="5" as="6" dim="7" />
           <Path path="10" as="11" dim="12" />
         </Paths>
       </Formula>
-      <Formula id="jdIkQXUjBkW1PZEvdqkRHA" name="MassTransferPeriportal2PericentralBC_liv" dim="Amount per time" formula="IsLiverZonated ? (Q_liv +Q_pve)*HCT*C_bc : 0">
+      <Formula id="yI3_kGM0VEiluXC7Fx9OVQ" name="MassTransferBloodPool2OrgPl" dim="Amount per time" formula="Q*(1-HCT)*C_pls">
         <Paths>
           <Path path="15" as="16" dim="17" />
           <Path path="18" as="19" dim="20" />
-          <Path path="21" as="22" dim="17" />
-          <Path path="23" as="24" />
-          <Path path="25" as="26" />
+          <Path path="21" as="22" />
         </Paths>
       </Formula>
-      <Formula id="U04MRgImN0KZG9cTpq7msQ" name="MassTransferPeriportal2PericentralPl_liv" dim="Amount per time" formula="IsLiverZonated ? (Q_liv +Q_pve)*(1-HCT)*C_pls : 0">
+      <Formula id="FqqH6QMGZkySSDAVip_wQA" name="MassTransferBloodPool2OrgPl_liv" dim="Amount per time" formula="Q*(1-HCT)*C_pls">
         <Paths>
-          <Path path="15" as="16" dim="17" />
-          <Path path="18" as="27" dim="20" />
-          <Path path="21" as="22" dim="17" />
-          <Path path="23" as="24" />
-          <Path path="25" as="26" />
+          <Path path="23" as="16" dim="17" />
+          <Path path="18" as="19" dim="20" />
+          <Path path="21" as="22" />
         </Paths>
       </Formula>
-      <Formula id="Y10Xjt4dh0ubhC1Xog2Oig" name="MassTransferBloodPool2OrgPl" dim="Amount per time" formula="Q*(1-HCT)*C_pls">
+      <Formula id="ZosLRCL7m0yJ8Tdw1lnwxQ" name="MassTransferBloodPool2OrgPl_lng" dim="Amount per time" formula="Q*(1-HCT)*C_pls">
         <Paths>
-          <Path path="28" as="29" dim="17" />
-          <Path path="18" as="27" dim="20" />
-          <Path path="23" as="24" />
+          <Path path="15" as="16" dim="17" />
+          <Path path="18" as="19" dim="20" />
+          <Path path="21" as="22" />
         </Paths>
       </Formula>
-      <Formula id="-FxcEYfqrEa6X8xgicVhZw" name="MassTransferBloodPool2OrgPl_liv" dim="Amount per time" formula="Q*(1-HCT)*C_pls">
+      <Formula id="1xopEa38v0uYsfAO4rcpUg" name="MassTransferBloodPool2OrgRBC" dim="Amount per time" formula="Q*HCT*C_bc">
         <Paths>
-          <Path path="15" as="29" dim="17" />
-          <Path path="18" as="27" dim="20" />
-          <Path path="23" as="24" />
+          <Path path="15" as="16" dim="17" />
+          <Path path="18" as="24" dim="20" />
+          <Path path="21" as="22" />
         </Paths>
       </Formula>
-      <Formula id="TnD-d_6iYUuedWCGR8j9Og" name="MassTransferBloodPool2OrgPl_lng" dim="Amount per time" formula="Q*(1-HCT)*C_pls">
+      <Formula id="r46P9x5-YUG-u6CmBBi0lg" name="MassTransferBloodPool2OrgRBC_liv" dim="Amount per time" formula="Q*HCT*C_bc">
         <Paths>
-          <Path path="28" as="29" dim="17" />
-          <Path path="18" as="27" dim="20" />
-          <Path path="23" as="24" />
+          <Path path="23" as="16" dim="17" />
+          <Path path="18" as="24" dim="20" />
+          <Path path="21" as="22" />
         </Paths>
       </Formula>
-      <Formula id="BbjH60Y1DUqibmx3K3VKXw" name="MassTransferBloodPool2OrgRBC" dim="Amount per time" formula="Q*HCT*C_bc">
+      <Formula id="sLmvPrc-sUCVloSXfdw_VQ" name="MassTransferBloodPool2OrgRBC_lng" dim="Amount per time" formula="Q*HCT*C_bc">
         <Paths>
-          <Path path="28" as="29" dim="17" />
-          <Path path="18" as="19" dim="20" />
-          <Path path="23" as="24" />
+          <Path path="15" as="16" dim="17" />
+          <Path path="18" as="24" dim="20" />
+          <Path path="21" as="22" />
         </Paths>
       </Formula>
-      <Formula id="XTgxVyjD6Ui11ybRKajDWg" name="MassTransferBloodPool2OrgRBC_liv" dim="Amount per time" formula="Q*HCT*C_bc">
+      <Formula id="dtAJKYRvzkShuOKuVmykqg" name="MassTransferIntestineToMucosaBC" dim="Amount per time" formula="MassTransferIntestineToMucosaBCRate">
         <Paths>
-          <Path path="15" as="29" dim="17" />
-          <Path path="18" as="19" dim="20" />
-          <Path path="23" as="24" />
+          <Path path="25" as="26" dim="2" />
         </Paths>
       </Formula>
-      <Formula id="BB62HuXiQUqx3__Xap7VVw" name="MassTransferBloodPool2OrgRBC_lng" dim="Amount per time" formula="Q*HCT*C_bc">
+      <Formula id="lq474X_Cn0SeIjd4tJrMFQ" name="MassTransferIntestineToMucosaPlasma" dim="Amount per time" formula="MassTransferIntestineToMucosaPlasmaRate">
         <Paths>
-          <Path path="28" as="29" dim="17" />
-          <Path path="18" as="19" dim="20" />
-          <Path path="23" as="24" />
+          <Path path="27" as="28" dim="2" />
         </Paths>
       </Formula>
-      <Formula id="v050G1l2c0GDIlqkbH2CSw" name="MassTransferSinLinPlasma2BloodPool_Pve" dim="Amount per time" formula="(1-fractQ)*Q*(1-HCT)*C">
+      <Formula id="-tpUBKGM30mnFtj-GF0dWQ" name="MassTransferSinLinPlasma2BloodPool_Pve" dim="Amount per time" formula="(1-fractQ)*Q*(1-HCT)*C">
         <Paths>
-          <Path path="15" as="29" dim="17" />
-          <Path path="30" as="31" />
-          <Path path="18" as="32" dim="20" />
-          <Path path="23" as="24" />
+          <Path path="23" as="16" dim="17" />
+          <Path path="29" as="30" />
+          <Path path="18" as="31" dim="20" />
+          <Path path="21" as="22" />
         </Paths>
       </Formula>
-      <Formula id="-K_rpC6I6U-WhC90rThnQQ" name="MassTransferSinLinRBC2BloodPool_Pve" dim="Amount per time" formula="(1-fractQ)*Q*HCT*C">
+      <Formula id="6yLx3bzNLEGAOBiBY2rUFg" name="MassTransferSinLinRBC2BloodPool_Pve" dim="Amount per time" formula="(1-fractQ)*Q*HCT*C">
         <Paths>
-          <Path path="15" as="29" dim="17" />
-          <Path path="30" as="31" />
-          <Path path="18" as="32" dim="20" />
-          <Path path="23" as="24" />
+          <Path path="23" as="16" dim="17" />
+          <Path path="29" as="30" />
+          <Path path="18" as="31" dim="20" />
+          <Path path="21" as="22" />
         </Paths>
       </Formula>
-      <Formula id="18a7-kn5n0ifl2dklhTYuA" name="MassTransferIntestineToMucosaBC" dim="Amount per time" formula="MassTransferIntestineToMucosaBCRate">
+      <Formula id="1Us1R6yn90G9Rr2BF9kTEQ" name="MassTransferMucosaToPveBC" dim="Amount per time" formula="MassTransferMucosaToPveBCRate">
         <Paths>
-          <Path path="33" as="34" dim="2" />
+          <Path path="32" as="33" dim="2" />
         </Paths>
       </Formula>
-      <Formula id="viF648G3CkeaN2b7RnERYA" name="MassTransferIntestineToMucosaPlasma" dim="Amount per time" formula="MassTransferIntestineToMucosaPlasmaRate">
+      <Formula id="gE16Gsjv6ESrKbbdppTiKg" name="MassTransferMucosaToPvePlasma" dim="Amount per time" formula="MassTransferMucosaToPvePlasmaRate">
         <Paths>
-          <Path path="35" as="36" dim="2" />
+          <Path path="34" as="35" dim="2" />
         </Paths>
       </Formula>
-      <Formula id="5SxPX-ZeS0W4-yjBHq3e8Q" name="MassTransferMucosaToPveBC" dim="Amount per time" formula="MassTransferMucosaToPveBCRate">
+      <Formula id="ky7WYH9ymEK2YdzJhHI8YA" name="MassTransferOrgPl2BloodPool" dim="Amount per time" formula="Q*(1-HCT)*C_pls">
         <Paths>
-          <Path path="37" as="38" dim="2" />
+          <Path path="23" as="16" dim="17" />
+          <Path path="18" as="19" dim="20" />
+          <Path path="21" as="22" />
         </Paths>
       </Formula>
-      <Formula id="s0PWlofqXUevOx0bxVnciQ" name="MassTransferMucosaToPvePlasma" dim="Amount per time" formula="MassTransferMucosaToPvePlasmaRate">
+      <Formula id="Ci3yFMPZd0iktOoM8TRc_g" name="MassTransferOrgPl2BloodPool_Liv" dim="Amount per time" formula="IsLiverZonated ? 0 : (Q_liv +Q_pve)*(1-HCT)*C_pls">
         <Paths>
-          <Path path="39" as="40" dim="2" />
+          <Path path="23" as="36" dim="17" />
+          <Path path="18" as="19" dim="20" />
+          <Path path="21" as="22" />
+          <Path path="37" as="38" />
+          <Path path="39" as="40" dim="17" />
         </Paths>
       </Formula>
-      <Formula id="69TdNTvo_U6kz3FGf4V3og" name="MassTransferOrgPl2BloodPool" dim="Amount per time" formula="Q*(1-HCT)*C_pls">
+      <Formula id="-i7bB9QENE2uGszRc4_SRg" name="MassTransferOrgPl2BloodPool_Liv_Pericentral" dim="Amount per time" formula="IsLiverZonated ? (Q_liv +Q_pve)*(1-HCT)*C_pls : 0">
         <Paths>
-          <Path path="15" as="29" dim="17" />
-          <Path path="18" as="27" dim="20" />
-          <Path path="23" as="24" />
+          <Path path="23" as="36" dim="17" />
+          <Path path="18" as="19" dim="20" />
+          <Path path="21" as="22" />
+          <Path path="37" as="38" />
+          <Path path="39" as="40" dim="17" />
         </Paths>
       </Formula>
-      <Formula id="cVjXgI7DOEa1ncXoGyJKzw" name="MassTransferOrgPl2BloodPool_Liv" dim="Amount per time" formula="IsLiverZonated ? 0 : (Q_liv +Q_pve)*(1-HCT)*C_pls">
+      <Formula id="4MvIF1cPgUmzDJ2zbgRUJQ" name="MassTransferOrgPl2BloodPool_Lng" dim="Amount per time" formula="Q*(1-HCT)*C_pls">
         <Paths>
-          <Path path="15" as="16" dim="17" />
-          <Path path="18" as="27" dim="20" />
-          <Path path="23" as="24" />
-          <Path path="25" as="26" />
-          <Path path="21" as="22" dim="17" />
+          <Path path="23" as="16" dim="17" />
+          <Path path="18" as="19" dim="20" />
+          <Path path="21" as="22" />
         </Paths>
       </Formula>
-      <Formula id="JyHO4GNUFECLeACVTvKGcQ" name="MassTransferOrgPl2BloodPool_Liv_Pericentral" dim="Amount per time" formula="IsLiverZonated ? (Q_liv +Q_pve)*(1-HCT)*C_pls : 0">
+      <Formula id="HDpkpI7cH0uTF_yj5G54qA" name="MassTransferOrgPl2BloodPool_pve" dim="Amount per time" formula="Q*(1-HCT)*C_pls">
         <Paths>
-          <Path path="15" as="16" dim="17" />
-          <Path path="18" as="27" dim="20" />
-          <Path path="23" as="24" />
-          <Path path="25" as="26" />
-          <Path path="21" as="22" dim="17" />
+          <Path path="23" as="16" dim="17" />
+          <Path path="18" as="19" dim="20" />
+          <Path path="21" as="22" />
         </Paths>
       </Formula>
-      <Formula id="7CZ6L6_CbE6iasiuCBxI5w" name="MassTransferOrgPl2BloodPool_Lng" dim="Amount per time" formula="Q*(1-HCT)*C_pls">
+      <Formula id="VhWmLCAkG0GnN5YyF4f99w" name="MassTransferOrgRBC2BloodPool" dim="Amount per time" formula="Q*HCT*C_bc">
         <Paths>
-          <Path path="15" as="29" dim="17" />
-          <Path path="18" as="27" dim="20" />
-          <Path path="23" as="24" />
+          <Path path="23" as="16" dim="17" />
+          <Path path="18" as="24" dim="20" />
+          <Path path="21" as="22" />
         </Paths>
       </Formula>
-      <Formula id="QoKRrSK8WEmTsiLhtsZvhg" name="MassTransferOrgPl2BloodPool_pve" dim="Amount per time" formula="Q*(1-HCT)*C_pls">
+      <Formula id="xN10-0Qtj0Scobsc1Ojj8g" name="MassTransferOrgRBC2BloodPool_Liv" dim="Amount per time" formula="IsLiverZonated ? 0 : (Q_liv +Q_pve)*HCT*C_bc">
         <Paths>
-          <Path path="15" as="29" dim="17" />
-          <Path path="18" as="27" dim="20" />
-          <Path path="23" as="24" />
+          <Path path="23" as="36" dim="17" />
+          <Path path="18" as="24" dim="20" />
+          <Path path="21" as="22" />
+          <Path path="37" as="38" />
+          <Path path="39" as="40" dim="17" />
         </Paths>
       </Formula>
-      <Formula id="l1jWjcGD-0uIHIvLAqd5dQ" name="MassTransferOrgRBC2BloodPool" dim="Amount per time" formula="Q*HCT*C_bc">
+      <Formula id="YJFd7Pkhhk6qKwR44nSOMA" name="MassTransferOrgRBC2BloodPool_Liv_Pericentral" dim="Amount per time" formula="IsLiverZonated ? (Q_liv +Q_pve)*HCT*C_bc : 0">
         <Paths>
-          <Path path="15" as="29" dim="17" />
-          <Path path="18" as="19" dim="20" />
-          <Path path="23" as="24" />
+          <Path path="23" as="36" dim="17" />
+          <Path path="18" as="24" dim="20" />
+          <Path path="21" as="22" />
+          <Path path="37" as="38" />
+          <Path path="39" as="40" dim="17" />
         </Paths>
       </Formula>
-      <Formula id="Lq5hdoNTpEWH75FhUTuFBg" name="MassTransferOrgRBC2BloodPool_Liv" dim="Amount per time" formula="IsLiverZonated ? 0 : (Q_liv +Q_pve)*HCT*C_bc">
+      <Formula id="judWqvLS_kqXBu9pGLRI6Q" name="MassTransferOrgRBC2BloodPool_Lng" dim="Amount per time" formula="Q*HCT*C_bc">
         <Paths>
-          <Path path="15" as="16" dim="17" />
-          <Path path="18" as="19" dim="20" />
-          <Path path="23" as="24" />
-          <Path path="25" as="26" />
-          <Path path="21" as="22" dim="17" />
+          <Path path="23" as="16" dim="17" />
+          <Path path="18" as="24" dim="20" />
+          <Path path="21" as="22" />
         </Paths>
       </Formula>
-      <Formula id="jAtqRpd3xUKqEjlB06dUxQ" name="MassTransferOrgRBC2BloodPool_Liv_Pericentral" dim="Amount per time" formula="IsLiverZonated ? (Q_liv +Q_pve)*HCT*C_bc : 0">
+      <Formula id="al1cphoWE0ydFX8487RBIA" name="MassTransferOrgRBC2BloodPool_Pve" dim="Amount per time" formula="Q*HCT*C_bc">
         <Paths>
-          <Path path="15" as="16" dim="17" />
-          <Path path="18" as="19" dim="20" />
-          <Path path="23" as="24" />
-          <Path path="25" as="26" />
-          <Path path="21" as="22" dim="17" />
+          <Path path="23" as="16" dim="17" />
+          <Path path="18" as="24" dim="20" />
+          <Path path="21" as="22" />
         </Paths>
       </Formula>
-      <Formula id="m6rYoibFLkOvUG0_R0lw4A" name="MassTransferOrgRBC2BloodPool_Lng" dim="Amount per time" formula="Q*HCT*C_bc">
+      <Formula id="9TMTIfAPVEmuoFZOWLRopQ" name="MassTransferPeriportal2PericentralBC_liv" dim="Amount per time" formula="IsLiverZonated ? (Q_liv +Q_pve)*HCT*C_bc : 0">
         <Paths>
-          <Path path="15" as="29" dim="17" />
-          <Path path="18" as="19" dim="20" />
-          <Path path="23" as="24" />
+          <Path path="23" as="36" dim="17" />
+          <Path path="18" as="24" dim="20" />
+          <Path path="39" as="40" dim="17" />
+          <Path path="21" as="22" />
+          <Path path="37" as="38" />
         </Paths>
       </Formula>
-      <Formula id="ny0E4VjN6kGOeLjALjbh7g" name="MassTransferOrgRBC2BloodPool_Pve" dim="Amount per time" formula="Q*HCT*C_bc">
+      <Formula id="IxEFR9qipkyx1VGW83Zqyg" name="MassTransferPeriportal2PericentralPl_liv" dim="Amount per time" formula="IsLiverZonated ? (Q_liv +Q_pve)*(1-HCT)*C_pls : 0">
         <Paths>
-          <Path path="15" as="29" dim="17" />
+          <Path path="23" as="36" dim="17" />
           <Path path="18" as="19" dim="20" />
-          <Path path="23" as="24" />
+          <Path path="39" as="40" dim="17" />
+          <Path path="21" as="22" />
+          <Path path="37" as="38" />
         </Paths>
       </Formula>
-      <Formula id="kXYwzLTQ3EaZ1heAkBvo2w" name="PassiveDiffusionInt2Cell" dim="Amount per time" formula="K_water_int * PA_int_cell * C_int - K_water_cell * PA_cell_int * C_cell">
+      <Formula id="GC1XkdtgWEOkSPm7yVgtGw" name="PassiveDiffusionInt2Cell" dim="Amount per time" formula="K_water_int * PA_int_cell * C_int - K_water_cell * PA_cell_int * C_cell">
         <Paths>
           <Path path="41" as="42" dim="20" />
           <Path path="18" as="43" dim="20" />
@@ -946,20 +946,20 @@
           <Path path="50" as="51" />
         </Paths>
       </Formula>
-      <Formula id="0fpOMWyaCEa5IoNVee9XXw" name="PassiveDiffusionPl2Int" dim="Amount per time" formula="fu * P_endothelial * SA * (C_pls - C_int / K_int_pls)">
+      <Formula id="CL-Y2y2R0kyJ-p69S4YgeQ" name="PassiveDiffusionPl2Int" dim="Amount per time" formula="fu * P_endothelial * SA * (C_pls - C_int / K_int_pls)">
         <Paths>
           <Path path="41" as="43" dim="20" />
-          <Path path="18" as="27" dim="20" />
+          <Path path="18" as="19" dim="20" />
           <Path path="52" as="53" dim="54" />
           <Path path="55" as="56" dim="57" />
           <Path path="58" as="59" />
           <Path path="60" as="61" dim="62" />
         </Paths>
       </Formula>
-      <Formula id="WiLogmDBKUurwF7Q3klC0g" name="PassiveDiffusionPl2RBC" dim="Amount per time" formula="SA_bc * fu * (P_pls_rbc * C_pls - P_rbc_pls * C_bc  /K_rbc)">
+      <Formula id="VmjrE0ErB0WyJBIY7d-8Gg" name="PassiveDiffusionPl2RBC" dim="Amount per time" formula="SA_bc * fu * (P_pls_rbc * C_pls - P_rbc_pls * C_bc  /K_rbc)">
         <Paths>
-          <Path path="41" as="19" dim="20" />
-          <Path path="18" as="27" dim="20" />
+          <Path path="41" as="24" dim="20" />
+          <Path path="18" as="19" dim="20" />
           <Path path="52" as="53" dim="54" />
           <Path path="63" as="64" dim="57" />
           <Path path="65" as="66" dim="57" />
@@ -967,7 +967,7 @@
           <Path path="69" as="70" dim="62" />
         </Paths>
       </Formula>
-      <Formula id="KawN5BAaREC8eWVnNjRxNQ" name="PassiveDiffusionPlsToSaliva" dim="Amount per time" formula="fu * (C_pls_art - C_slv / K_slv_pls) * Q_slv">
+      <Formula id="rQHuihnMj0KUKH0eYUtPBQ" name="PassiveDiffusionPlsToSaliva" dim="Amount per time" formula="fu * (C_pls_art - C_slv / K_slv_pls) * Q_slv">
         <Paths>
           <Path path="71" as="72" dim="17" />
           <Path path="73" as="74" dim="20" />
@@ -976,7 +976,7 @@
           <Path path="76" as="77" />
         </Paths>
       </Formula>
-      <Formula id="XGeF5rtzlUKzL58UQwql4Q" name="GallbladderEmptyingRate" dim="Amount per time" formula="EHC_Active ? ln(2) / EHC_Halftime * M * EHC_EjectionFraction : 0">
+      <Formula id="Iqph7dBe_U2weZVDV75hAA" name="GallbladderEmptyingRate" dim="Amount per time" formula="EHC_Active ? ln(2) / EHC_Halftime * M * EHC_EjectionFraction : 0">
         <Paths>
           <Path path="78" as="79" dim="7" />
           <Path path="80" as="81" dim="54" />
@@ -1001,32 +1001,32 @@
       <Map s="Inversed time" id="12" />
       <Map s="TARGET|FillLevelFlag" id="13" />
       <Map s="FillLevelFlagNext" id="14" />
-      <Map s="SOURCE|..|Blood flow rate" id="15" />
-      <Map s="Q_liv" id="16" />
+      <Map s="TARGET|..|Blood flow rate" id="15" />
+      <Map s="Q" id="16" />
       <Map s="Flow" id="17" />
       <Map s="SOURCE|MOLECULE|Concentration" id="18" />
-      <Map s="C_bc" id="19" />
+      <Map s="C_pls" id="19" />
       <Map s="Concentration (molar)" id="20" />
-      <Map s="Organism|PortalVein|Blood flow rate" id="21" />
-      <Map s="Q_pve" id="22" />
-      <Map s="Organism|Hematocrit" id="23" />
-      <Map s="HCT" id="24" />
-      <Map s="Organism|Liver|Is liver zonated" id="25" />
-      <Map s="IsLiverZonated" id="26" />
-      <Map s="C_pls" id="27" />
-      <Map s="TARGET|..|Blood flow rate" id="28" />
-      <Map s="Q" id="29" />
-      <Map s="SOURCE|..|Mucosa blood flow fraction" id="30" />
-      <Map s="fractQ" id="31" />
-      <Map s="C" id="32" />
-      <Map s="NEIGHBORHOOD|MOLECULE|Mass transfer rate (intestine to mucosa blood cells)" id="33" />
-      <Map s="MassTransferIntestineToMucosaBCRate" id="34" />
-      <Map s="NEIGHBORHOOD|MOLECULE|Mass transfer rate (intestine to mucosa plasma)" id="35" />
-      <Map s="MassTransferIntestineToMucosaPlasmaRate" id="36" />
-      <Map s="NEIGHBORHOOD|MOLECULE|Mass transfer rate (mucosa to portal vein blood cells)" id="37" />
-      <Map s="MassTransferMucosaToPveBCRate" id="38" />
-      <Map s="NEIGHBORHOOD|MOLECULE|Mass transfer rate (mucosa to portal vein plasma)" id="39" />
-      <Map s="MassTransferMucosaToPvePlasmaRate" id="40" />
+      <Map s="Organism|Hematocrit" id="21" />
+      <Map s="HCT" id="22" />
+      <Map s="SOURCE|..|Blood flow rate" id="23" />
+      <Map s="C_bc" id="24" />
+      <Map s="NEIGHBORHOOD|MOLECULE|Mass transfer rate (intestine to mucosa blood cells)" id="25" />
+      <Map s="MassTransferIntestineToMucosaBCRate" id="26" />
+      <Map s="NEIGHBORHOOD|MOLECULE|Mass transfer rate (intestine to mucosa plasma)" id="27" />
+      <Map s="MassTransferIntestineToMucosaPlasmaRate" id="28" />
+      <Map s="SOURCE|..|Mucosa blood flow fraction" id="29" />
+      <Map s="fractQ" id="30" />
+      <Map s="C" id="31" />
+      <Map s="NEIGHBORHOOD|MOLECULE|Mass transfer rate (mucosa to portal vein blood cells)" id="32" />
+      <Map s="MassTransferMucosaToPveBCRate" id="33" />
+      <Map s="NEIGHBORHOOD|MOLECULE|Mass transfer rate (mucosa to portal vein plasma)" id="34" />
+      <Map s="MassTransferMucosaToPvePlasmaRate" id="35" />
+      <Map s="Q_liv" id="36" />
+      <Map s="Organism|Liver|Is liver zonated" id="37" />
+      <Map s="IsLiverZonated" id="38" />
+      <Map s="Organism|PortalVein|Blood flow rate" id="39" />
+      <Map s="Q_pve" id="40" />
       <Map s="TARGET|MOLECULE|Concentration" id="41" />
       <Map s="C_cell" id="42" />
       <Map s="C_int" id="43" />
diff --git a/src/MoBi.Assets/AppConstants.cs b/src/MoBi.Assets/AppConstants.cs
index d34e6bb63..d2deb44cf 100644
--- a/src/MoBi.Assets/AppConstants.cs
+++ b/src/MoBi.Assets/AppConstants.cs
@@ -9,6 +9,7 @@
 using OSPSuite.Core.Domain.Formulas;
 using OSPSuite.Core.Domain.UnitSystem;
 using OSPSuite.Utility.Extensions;
+using static OSPSuite.Assets.MenuNames;
 
 namespace MoBi.Assets
 {
@@ -871,7 +872,7 @@ public static string AskForChangedName(string oldName, string typeName)
 
          public static string AskForNewName(string name)
          {
-            return string.Format("Please enter new name");
+            return "Please enter new name";
          }
 
          public static string AskFileOverride(string fileName)
@@ -886,7 +887,9 @@ public static string AskForNewNeighborhoodBuilderName(string container1Name, str
 
          public static readonly string ExportSimulationModelToFileTitle = "Export model structure to text file";
          public static readonly string ExportSimulationResultsToExcel = "Export simulation results to Excel®";
-         public static readonly string ExportSimulationMatlabODE = "Export simulation to Matlab® ODE";
+         public static readonly string ExportODEForMatlab = "Export simulation to Matlab® ODE";
+         public static readonly string ExportODEForR = "Export simulation to R ODE";
+         public static readonly string ExportSimulationToCppCode = "Export simulation to C++ code";
          public static readonly string LoadSBMLProject = "Load SBML Project";
 
          public static string Load(string objectType)
@@ -982,7 +985,6 @@ public static class MenuNames
          public static readonly string AbsolutePath = "Absolute Path";
          public static readonly string ExportHistory = Captions.ExportHistory;
          public static readonly string StartPopulationSimulation = "Send Simulation to PK-Sim for Population Simulation...";
-         public static readonly string ExportSimModelXml = "Export Simulation for Matlab®/R...";
          public static readonly string BuildingBlockExplorer = "Building Blocks";
          public static readonly string SimulationExplorer = "Simulations";
          public static readonly string New = "New";
@@ -1033,7 +1035,6 @@ public static class MenuNames
          public static readonly string SearchView = "Search";
          public static readonly string NotificationView = "Notifications";
          public static readonly string ComparisonView = "Comparison";
-         public static readonly string MatlabDifferentialSystemExport = "Export Simulation to Matlab® Differential Equations...";
          public static readonly string GoTo = "Go To...";
          public static readonly string DiscardResults = "Discard";
          public static readonly string KeepResults = "Keep";
@@ -1951,22 +1952,6 @@ public static string MoleculeNodeAlreadyExistsForMolecule(string moleculeName)
          }
       }
 
-      public static string RHSDefaultUnitName(IDimension dimension)
-      {
-         var numerator = string.IsNullOrEmpty(dimension.BaseUnit.Name) ? "1" : dimension.BaseUnit.Name;
-         if (string.Equals(numerator, "min"))
-            return string.Empty;
-
-         return $"{numerator}/min";
-      }
-
-      public static string RHSDimensionSuffix = " per time";
-
-      public static string RHSDimensionName(IDimension dimension)
-      {
-         return $"{dimension.Name}{RHSDimensionSuffix}";
-      }
-
       public static readonly IEnumerable<string> UnallowedNames = new List<string>
       {
          string.Empty,
@@ -2026,8 +2011,12 @@ public static string CompositeNameFor(string name1, string name2)
          return $"{name1}-{name2}";
       }
 
-      public static string ProjectVersionCannotBeLoaded(int projectVersion, int currentVersion, string downloadUrl)
+      public static string ProjectVersionCannotBeLoaded(int projectVersion, int currentVersion, bool projectIsTooOld, string downloadUrl)
       {
+         if (projectIsTooOld)
+            return $"The project is too old (compatible version {projectVersion}) and cannot be loaded with this version. (compatible version {currentVersion}).\n" +
+                   $"Visit our download page at {downloadUrl} to download an older version of the software compatible with this project.";
+
          if (projectVersion > currentVersion)
             return $"The application is too old (compatible version {currentVersion}) and cannot load a project created with a newer version (project version {projectVersion}).\nVisit our download page at {downloadUrl}";
 
diff --git a/src/MoBi.Assets/MoBi.Assets.csproj b/src/MoBi.Assets/MoBi.Assets.csproj
index 5c190d0a3..726ecb50d 100644
--- a/src/MoBi.Assets/MoBi.Assets.csproj
+++ b/src/MoBi.Assets/MoBi.Assets.csproj
@@ -1,119 +1,40 @@
-<?xml version="1.0" encoding="utf-8"?>
-<Project ToolsVersion="12.0" DefaultTargets="Build" xmlns="http://schemas.microsoft.com/developer/msbuild/2003">
+<Project Sdk="Microsoft.NET.Sdk">
+
   <PropertyGroup>
-    <Configuration Condition=" '$(Configuration)' == '' ">Debug</Configuration>
-    <Platform Condition=" '$(Platform)' == '' ">AnyCPU</Platform>
-    <ProductVersion>9.0.21022</ProductVersion>
-    <SchemaVersion>2.0</SchemaVersion>
-    <ProjectGuid>{3C65FFC2-D9EC-4951-8C35-04854AD34E52}</ProjectGuid>
-    <OutputType>Library</OutputType>
-    <AppDesignerFolder>Properties</AppDesignerFolder>
-    <RootNamespace>MoBi.Assets</RootNamespace>
-    <AssemblyName>MoBi.Assets</AssemblyName>
-    <TargetFrameworkVersion>v4.6.2</TargetFrameworkVersion>
-    <FileAlignment>512</FileAlignment>
-    <FileUpgradeFlags>
-    </FileUpgradeFlags>
-    <UpgradeBackupLocation>
-    </UpgradeBackupLocation>
-    <OldToolsVersion>3.5</OldToolsVersion>
-    <TargetFrameworkProfile />
-  </PropertyGroup>
-  <PropertyGroup Condition=" '$(Configuration)|$(Platform)' == 'Debug|AnyCPU' ">
-    <DebugSymbols>true</DebugSymbols>
-    <DebugType>full</DebugType>
-    <Optimize>false</Optimize>
-    <OutputPath>bin\Debug\</OutputPath>
-    <DefineConstants>DEBUG;TRACE</DefineConstants>
-    <ErrorReport>prompt</ErrorReport>
-    <WarningLevel>4</WarningLevel>
-    <NoWarn>1591</NoWarn>
-    <Prefer32Bit>false</Prefer32Bit>
-    <PlatformTarget>AnyCPU</PlatformTarget>
-  </PropertyGroup>
-  <PropertyGroup Condition=" '$(Configuration)|$(Platform)' == 'Release|AnyCPU' ">
-    <DebugType>pdbonly</DebugType>
-    <Optimize>true</Optimize>
-    <OutputPath>bin\Release\</OutputPath>
-    <DefineConstants>TRACE</DefineConstants>
-    <ErrorReport>prompt</ErrorReport>
-    <WarningLevel>4</WarningLevel>
-    <Prefer32Bit>false</Prefer32Bit>
+    <TargetFramework>netstandard2.0</TargetFramework>
+    <Version>9.0.0</Version>
+    <PackageVersion>9.0.0</PackageVersion>
+    <AssemblyVersion>9.0.0</AssemblyVersion>
+    <FileVersion>9.0.0</FileVersion>
+    <InformationalVersion>9.0.0</InformationalVersion>
+    <GenerateAssemblyProductAttribute>false</GenerateAssemblyProductAttribute>
+    <GenerateAssemblyCompanyAttribute>false</GenerateAssemblyCompanyAttribute>
+    <PackageTags>open-systems-pharmacology, ospsuite-components</PackageTags>
+    <Authors>Open-Systems-Pharmacology</Authors>
+    <PackageLicenseFile>LICENSE</PackageLicenseFile>
+    <OutputPath>bin\$(Configuration)</OutputPath>
+    <DocumentationFile>bin\$(Configuration)\$(TargetFramework)\$(AssemblyName).xml</DocumentationFile>
+    <NoWarn>1591, 3246</NoWarn>
   </PropertyGroup>
+
   <ItemGroup>
-    <Reference Include="MathNet.Numerics, Version=4.7.0.0, Culture=neutral, processorArchitecture=MSIL">
-      <HintPath>..\..\packages\MathNet.Numerics.4.7.0\lib\net461\MathNet.Numerics.dll</HintPath>
-    </Reference>
-    <Reference Include="Microsoft.Extensions.Logging.Abstractions, Version=2.2.0.0, Culture=neutral, PublicKeyToken=adb9793829ddae60, processorArchitecture=MSIL">
-      <HintPath>..\..\packages\Microsoft.Extensions.Logging.Abstractions.2.2.0\lib\netstandard2.0\Microsoft.Extensions.Logging.Abstractions.dll</HintPath>
-    </Reference>
-    <Reference Include="MPFitLib, Version=1.1.1.0, Culture=neutral, PublicKeyToken=be1b3c0b5819660a, processorArchitecture=MSIL">
-      <HintPath>..\..\packages\csmpfit.1.1.1\lib\net20\MPFitLib.dll</HintPath>
-    </Reference>
-    <Reference Include="OSPSuite.Assets, Version=8.0.4.0, Culture=neutral, processorArchitecture=MSIL">
-      <HintPath>..\..\packages\OSPSuite.Assets.8.0.4\lib\net462\OSPSuite.Assets.dll</HintPath>
-    </Reference>
-    <Reference Include="OSPSuite.Core, Version=8.0.4.0, Culture=neutral, processorArchitecture=MSIL">
-      <HintPath>..\..\packages\OSPSuite.Core.8.0.4\lib\net462\OSPSuite.Core.dll</HintPath>
-    </Reference>
-    <Reference Include="OSPSuite.Serializer, Version=2.0.1.4, Culture=neutral, processorArchitecture=MSIL">
-      <HintPath>..\..\packages\OSPSuite.Serializer.2.0.1.4\lib\net45\OSPSuite.Serializer.dll</HintPath>
-    </Reference>
-    <Reference Include="OSPSuite.TeXReporting, Version=2.1.1.9, Culture=neutral, processorArchitecture=MSIL">
-      <HintPath>..\..\packages\OSPSuite.TeXReporting.2.1.1.9\lib\net45\OSPSuite.TeXReporting.dll</HintPath>
-    </Reference>
-    <Reference Include="OSPSuite.Utility, Version=3.0.1.7, Culture=neutral, processorArchitecture=MSIL">
-      <HintPath>..\..\packages\OSPSuite.Utility.3.0.1.7\lib\net462\OSPSuite.Utility.dll</HintPath>
-    </Reference>
-    <Reference Include="System" />
-    <Reference Include="System.Core">
-      <RequiredTargetFramework>3.5</RequiredTargetFramework>
-    </Reference>
-    <Reference Include="System.Drawing" />
-    <Reference Include="System.Numerics" />
-    <Reference Include="System.Runtime.Serialization" />
-    <Reference Include="System.ValueTuple, Version=4.0.2.0, Culture=neutral, PublicKeyToken=cc7b13ffcd2ddd51, processorArchitecture=MSIL">
-      <HintPath>..\..\packages\System.ValueTuple.4.4.0\lib\netstandard1.0\System.ValueTuple.dll</HintPath>
-    </Reference>
-    <Reference Include="System.Windows.Forms" />
-    <Reference Include="System.Xml.Linq">
-      <RequiredTargetFramework>3.5</RequiredTargetFramework>
-    </Reference>
-    <Reference Include="System.Data.DataSetExtensions">
-      <RequiredTargetFramework>3.5</RequiredTargetFramework>
-    </Reference>
-    <Reference Include="System.Data" />
-    <Reference Include="System.Xml" />
+    <Compile Include="..\..\SolutionInfo.cs" Link="Properties\SolutionInfo.cs" />
   </ItemGroup>
+
   <ItemGroup>
-    <Compile Include="..\..\SolutionInfo.cs">
-      <Link>Properties\SolutionInfo.cs</Link>
-    </Compile>
-    <Compile Include="AppConstants.cs" />
-    <Compile Include="Properties\AssemblyInfo.cs" />
-    <Compile Include="ToolTips.cs" />
+    <Folder Include="Properties\" />
   </ItemGroup>
+
   <ItemGroup>
-    <None Include="packages.config">
-      <SubType>Designer</SubType>
-    </None>
+    <PackageReference Include="OSPSuite.Assets" Version="9.0.137" />
+    <PackageReference Include="OSPSuite.Assets.Images" Version="9.0.137" />
+    <PackageReference Include="OSPSuite.Core" Version="9.0.137" />
   </ItemGroup>
+
   <ItemGroup>
-    <Content Include="Resources\About.bmp" />
-    <Content Include="Resources\FileIcon.ico" />
-    <Content Include="Resources\Logo_MoBi.jpg" />
-    <Content Include="Resources\MoBi.ico" />
-    <Content Include="Resources\Model4Comp.TIF" />
-    <Content Include="Resources\Model4Comp2Pores.TIF" />
-    <Content Include="Resources\PKML.ico" />
-    <Content Include="Resources\PKSim.jpg" />
+    <None Include="..\..\LICENSE">
+      <Pack>True</Pack>
+      <PackagePath></PackagePath>
+    </None>
   </ItemGroup>
-  <Import Project="$(MSBuildToolsPath)\Microsoft.CSharp.targets" />
-  <!-- To modify your build process, add your task inside one of the targets below and uncomment it. 
-       Other similar extension points exist, see Microsoft.Common.targets.
-  <Target Name="BeforeBuild">
-  </Target>
-  <Target Name="AfterBuild">
-  </Target>
-  -->
-</Project>
\ No newline at end of file
+</Project>
diff --git a/src/MoBi.Assets/Properties/AssemblyInfo.cs b/src/MoBi.Assets/Properties/AssemblyInfo.cs
deleted file mode 100644
index 365eeb576..000000000
--- a/src/MoBi.Assets/Properties/AssemblyInfo.cs
+++ /dev/null
@@ -1,10 +0,0 @@
-using System.Reflection;
-using System.Runtime.CompilerServices;
-
-// General Information about an assembly is controlled through the following 
-// set of attributes. Change these attribute values to modify the information
-// associated with an assembly.
-
-[assembly: AssemblyTitle("MoBi.Assets")]
-[assembly: AssemblyDescription("")]
-[assembly: AssemblyCulture("")]
diff --git a/src/MoBi.Assets/packages.config b/src/MoBi.Assets/packages.config
deleted file mode 100644
index 4d01d30a7..000000000
--- a/src/MoBi.Assets/packages.config
+++ /dev/null
@@ -1,12 +0,0 @@
-<?xml version="1.0" encoding="utf-8"?>
-<packages>
-  <package id="csmpfit" version="1.1.1" targetFramework="net462" />
-  <package id="MathNet.Numerics" version="4.7.0" targetFramework="net462" />
-  <package id="Microsoft.Extensions.Logging.Abstractions" version="2.2.0" targetFramework="net462" />
-  <package id="OSPSuite.Assets" version="8.0.4" targetFramework="net462" />
-  <package id="OSPSuite.Core" version="8.0.4" targetFramework="net462" />
-  <package id="OSPSuite.Serializer" version="2.0.1.4" targetFramework="net462" />
-  <package id="OSPSuite.TeXReporting" version="2.1.1.9" targetFramework="net462" />
-  <package id="OSPSuite.Utility" version="3.0.1.7" targetFramework="net462" />
-  <package id="System.ValueTuple" version="4.4.0" targetFramework="net462" />
-</packages>
\ No newline at end of file
diff --git a/src/MoBi.BatchTool/App.config b/src/MoBi.BatchTool/App.config
index 08a958531..456471cb5 100644
--- a/src/MoBi.BatchTool/App.config
+++ b/src/MoBi.BatchTool/App.config
@@ -1,122 +1,14 @@
 <?xml version="1.0" encoding="utf-8"?>
 <configuration>
-    <startup> 
-        <supportedRuntime version="v4.0" sku=".NETFramework,Version=v4.6.2" />
-    </startup>
+  <startup useLegacyV2RuntimeActivationPolicy="true">
+    <supportedRuntime version="v4.0" sku=".NETFramework,Version=v4.7.2" />
+  </startup>
   <runtime>
     <assemblyBinding xmlns="urn:schemas-microsoft-com:asm.v1">
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.XtraEditors.v18.2" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.Data.v18.2" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.XtraGrid.v18.2" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.Utils.v18.2" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.XtraTreeList.v18.2" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.XtraLayout.v18.2" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.XtraBars.v18.2" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.XtraCharts.v18.2.UI" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.XtraCharts.v18.2" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.XtraPivotGrid.v18.2" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.PivotGrid.v18.2.Core" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.RichEdit.v18.2.Core" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.XtraRichEdit.v18.2" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.XtraRichEdit.v18.2.Extensions" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.Charts.v18.2.Core" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
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-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
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-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
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-        <bindingRedirect oldVersion="0.0.0.0-4.0.0.0" newVersion="4.0.0.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="MPFitLib" publicKeyToken="be1b3c0b5819660a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-1.1.0.0" newVersion="1.1.0.0" />
-      </dependentAssembly>
-      <dependentAssembly>
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-        <bindingRedirect oldVersion="0.0.0.0-0.86.0.518" newVersion="0.86.0.518" />
-      </dependentAssembly>
-      <dependentAssembly>
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-        <bindingRedirect oldVersion="0.0.0.0-1.0.110.0" newVersion="1.0.110.0" />
-      </dependentAssembly>
-      <dependentAssembly>
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-        <bindingRedirect oldVersion="0.0.0.0-5.2.0.45" newVersion="5.2.0.45" />
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-        <bindingRedirect oldVersion="0.0.0.0-5.2.0.45" newVersion="5.2.0.45" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="NHibernate" publicKeyToken="aa95f207798dfdb4" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-5.2.0.0" newVersion="5.2.0.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="Iesi.Collections" publicKeyToken="aa95f207798dfdb4" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-4.0.0.4000" newVersion="4.0.0.4000" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="Newtonsoft.Json" publicKeyToken="30ad4fe6b2a6aeed" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-10.0.0.0" newVersion="10.0.0.0" />
-      </dependentAssembly>
       <dependentAssembly>
         <assemblyIdentity name="SX" publicKeyToken="882b9c044052e7f6" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-2.7.0.9" newVersion="2.7.0.9" />
+        <bindingRedirect oldVersion="0.0.0.0-2.7.4.7" newVersion="2.7.4.7" />
       </dependentAssembly>
     </assemblyBinding>
   </runtime>
-</configuration>
+</configuration>
\ No newline at end of file
diff --git a/src/MoBi.BatchTool/MoBi.BatchTool.csproj b/src/MoBi.BatchTool/MoBi.BatchTool.csproj
index 7980f513e..b1bb49619 100644
--- a/src/MoBi.BatchTool/MoBi.BatchTool.csproj
+++ b/src/MoBi.BatchTool/MoBi.BatchTool.csproj
@@ -1,406 +1,77 @@
-<?xml version="1.0" encoding="utf-8"?>
-<Project ToolsVersion="12.0" DefaultTargets="Build" xmlns="http://schemas.microsoft.com/developer/msbuild/2003">
-  <Import Project="$(MSBuildExtensionsPath)\$(MSBuildToolsVersion)\Microsoft.Common.props" Condition="Exists('$(MSBuildExtensionsPath)\$(MSBuildToolsVersion)\Microsoft.Common.props')" />
+<Project Sdk="Microsoft.NET.Sdk">
+
   <PropertyGroup>
-    <Configuration Condition=" '$(Configuration)' == '' ">Debug</Configuration>
-    <Platform Condition=" '$(Platform)' == '' ">AnyCPU</Platform>
-    <ProjectGuid>{881D23DB-4A9F-45C8-BA67-58B790537634}</ProjectGuid>
+    <TargetFramework>net472</TargetFramework>
     <OutputType>WinExe</OutputType>
-    <AppDesignerFolder>Properties</AppDesignerFolder>
-    <RootNamespace>MoBi.BatchTool</RootNamespace>
-    <AssemblyName>MoBi.BatchTool</AssemblyName>
-    <AutoGenerateBindingRedirects>true</AutoGenerateBindingRedirects>
-    <TargetFrameworkVersion>v4.6.2</TargetFrameworkVersion>
-    <FileAlignment>512</FileAlignment>
-    <TargetFrameworkProfile />
-    <NuGetPackageImportStamp>
-    </NuGetPackageImportStamp>
+    <Version>9.0.0</Version>
+    <PackageVersion>9.0.0</PackageVersion>
+    <AssemblyVersion>9.0.0</AssemblyVersion>
+    <FileVersion>9.0.0</FileVersion>
+    <InformationalVersion>9.0.0</InformationalVersion>
+    <GenerateAssemblyProductAttribute>false</GenerateAssemblyProductAttribute>
+    <GenerateAssemblyCompanyAttribute>false</GenerateAssemblyCompanyAttribute>
+    <Authors>Open-Systems-Pharmacology</Authors>
+    <PackageLicenseFile>LICENSE</PackageLicenseFile>
+    <OutputPath>bin\$(Configuration)</OutputPath>
+    <DocumentationFile>bin\$(Configuration)\$(TargetFramework)\$(AssemblyName).xml</DocumentationFile>
+    <NoWarn>1591, 3246</NoWarn>
+    <ApplicationIcon>MoBi.ico</ApplicationIcon>
+    <Description>MoBi.BatchTool</Description>
   </PropertyGroup>
-  <PropertyGroup Condition=" '$(Configuration)|$(Platform)' == 'Debug|AnyCPU' ">
+
+  <PropertyGroup Condition="'$(Configuration)|$(Platform)'=='Debug|AnyCPU'">
     <PlatformTarget>x64</PlatformTarget>
-    <DebugSymbols>true</DebugSymbols>
-    <DebugType>full</DebugType>
-    <Optimize>false</Optimize>
-    <OutputPath>bin\Debug\</OutputPath>
-    <DefineConstants>DEBUG;TRACE</DefineConstants>
-    <ErrorReport>prompt</ErrorReport>
-    <WarningLevel>4</WarningLevel>
-  </PropertyGroup>
-  <PropertyGroup Condition=" '$(Configuration)|$(Platform)' == 'Release|AnyCPU' ">
-    <PlatformTarget>AnyCPU</PlatformTarget>
-    <DebugType>pdbonly</DebugType>
-    <Optimize>true</Optimize>
-    <OutputPath>bin\Release\</OutputPath>
-    <DefineConstants>TRACE</DefineConstants>
-    <ErrorReport>prompt</ErrorReport>
-    <WarningLevel>4</WarningLevel>
   </PropertyGroup>
+
   <ItemGroup>
-    <Reference Include="Antlr3.Runtime, Version=3.5.0.2, Culture=neutral, PublicKeyToken=eb42632606e9261f, processorArchitecture=MSIL">
-      <HintPath>..\..\packages\Antlr3.Runtime.3.5.1\lib\net40-client\Antlr3.Runtime.dll</HintPath>
-    </Reference>
-    <Reference Include="Castle.Core, Version=4.0.0.0, Culture=neutral, PublicKeyToken=407dd0808d44fbdc, processorArchitecture=MSIL">
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-    <Compile Include="Views\IFileFromFolderRunnerView.cs" />
-    <Compile Include="Views\FileFromFolderRunnerView.cs">
-      <SubType>Form</SubType>
-    </Compile>
-    <Compile Include="Views\FileFromFolderRunnerView.Designer.cs">
-      <DependentUpon>FileFromFolderRunnerView.cs</DependentUpon>
-    </Compile>
-    <EmbeddedResource Include="Properties\licenses.licx" />
-    <EmbeddedResource Include="Properties\Resources.resx">
-      <Generator>ResXFileCodeGenerator</Generator>
-      <LastGenOutput>Resources.Designer.cs</LastGenOutput>
-      <SubType>Designer</SubType>
-    </EmbeddedResource>
-    <Compile Include="Properties\Resources.Designer.cs">
-      <AutoGen>True</AutoGen>
-      <DependentUpon>Resources.resx</DependentUpon>
-      <DesignTime>True</DesignTime>
-    </Compile>
-    <EmbeddedResource Include="Views\BatchMainView.resx">
-      <DependentUpon>BatchMainView.cs</DependentUpon>
-    </EmbeddedResource>
-    <EmbeddedResource Include="Views\FileFromFolderRunnerView.resx">
-      <DependentUpon>FileFromFolderRunnerView.cs</DependentUpon>
-    </EmbeddedResource>
-    <None Include="packages.config">
-      <SubType>Designer</SubType>
-    </None>
-    <None Include="Properties\Settings.settings">
-      <Generator>SettingsSingleFileGenerator</Generator>
-      <LastGenOutput>Settings.Designer.cs</LastGenOutput>
-    </None>
-    <Compile Include="Properties\Settings.Designer.cs">
-      <AutoGen>True</AutoGen>
-      <DependentUpon>Settings.settings</DependentUpon>
-      <DesignTimeSharedInput>True</DesignTimeSharedInput>
-    </Compile>
+    <Compile Include="..\..\SolutionInfo.cs" Link="Properties\SolutionInfo.cs" />
   </ItemGroup>
+
   <ItemGroup>
-    <None Include="App.config">
-      <SubType>Designer</SubType>
+    <Content Include="..\..\dimensions\OSPSuite.Dimensions.xml" Link="OSPSuite.Dimensions.xml">
+      <CopyToOutputDirectory>PreserveNewest</CopyToOutputDirectory>
+    </Content>
+    <Content Include="..\..\pkparameters\OSPSuite.PKParameters.xml" Link="OSPSuite.PKParameters.xml">
+      <CopyToOutputDirectory>PreserveNewest</CopyToOutputDirectory>
+    </Content>
+    <Content Include="$(PkgOSPSuite_FuncParser)\OSPSuite.FuncParserNative\bin\native\x64\Release\OSPSuite.FuncParserNative.dll" Link="OSPSuite.FuncParserNative.dll">
+      <CopyToOutputDirectory>PreserveNewest</CopyToOutputDirectory>
+    </Content>
+    <Content Include="$(PkgOSPSuite_SimModel)\OSPSuite.SimModelNative\bin\native\x64\Release\OSPSuite.SimModelNative.dll" Link="OSPSuite.SimModelNative.dll">
+      <CopyToOutputDirectory>PreserveNewest</CopyToOutputDirectory>
+    </Content>
+    <Content Include="$(PkgOSPSuite_SimModelSolver_CVODES)\OSPSuite.SimModelSolver_CVODES\bin\native\x64\Release\OSPSuite.SimModelSolver_CVODES.dll" Link="OSPSuite.SimModelSolver_CVODES.dll">
+      <CopyToOutputDirectory>PreserveNewest</CopyToOutputDirectory>
+    </Content>
+    <Content Include="$(PkgSystem_Data_SQLite_Core)\build\net46\x64\SQLite.Interop.dll" Link="SQLite.Interop.dll">
+      <CopyToOutputDirectory>PreserveNewest</CopyToOutputDirectory>
+    </Content>
+  </ItemGroup>
+
+  <ItemGroup>
+    <None Include="..\..\LICENSE">
+      <Pack>True</Pack>
+      <PackagePath></PackagePath>
     </None>
   </ItemGroup>
+
   <ItemGroup>
-    <ProjectReference Include="..\MoBi.Core\MoBi.Core.csproj">
-      <Project>{2DBF50BE-A749-421C-B526-8BDA31CFE7B3}</Project>
-      <Name>MoBi.Core</Name>
-    </ProjectReference>
-    <ProjectReference Include="..\MoBi.Engine\MoBi.Engine.csproj">
-      <Project>{15ed932c-edec-407b-91d9-7bcb8e7f95f5}</Project>
-      <Name>MoBi.Engine</Name>
-    </ProjectReference>
-    <ProjectReference Include="..\MoBi.Presentation\MoBi.Presentation.csproj">
-      <Project>{B4C86DCA-8877-4400-8088-2401EE65B403}</Project>
-      <Name>MoBi.Presentation</Name>
-    </ProjectReference>
-    <ProjectReference Include="..\MoBi.Assets\MoBi.Assets.csproj">
-      <Project>{3C65FFC2-D9EC-4951-8C35-04854AD34E52}</Project>
-      <Name>MoBi.Assets</Name>
-    </ProjectReference>
-    <ProjectReference Include="..\MoBi.UI\MoBi.UI.csproj">
-      <Project>{DE743812-F444-42E2-B72D-CF298933E2BA}</Project>
-      <Name>MoBi.UI</Name>
-    </ProjectReference>
+    <PackageReference Include="OSPSuite.Core" Version="9.0.137" />
+    <PackageReference Include="OSPSuite.DevExpress" Version="19.2.4.1" />
+    <PackageReference Include="OSPSuite.FuncParser" Version="4.0.0.50" GeneratePathProperty="true" />
+    <PackageReference Include="OSPSuite.SimModel" Version="4.0.0.42" GeneratePathProperty="true" />
+    <PackageReference Include="OSPSuite.SimModelSolver_CVODES" Version="4.1.0.8" GeneratePathProperty="true" />
+    <PackageReference Include="System.Data.SQLite.Core" Version="1.0.112" GeneratePathProperty="true" />
   </ItemGroup>
+
   <ItemGroup>
-    <Content Include="..\..\packages\System.Data.SQLite.Core.1.0.110.0\build\net46\x64\SQLite.Interop.dll">
-      <Link>SQLite.Interop.dll</Link>
-      <CopyToOutputDirectory>PreserveNewest</CopyToOutputDirectory>
-    </Content>
+    <ProjectReference Include="..\MoBi.Core\MoBi.Core.csproj" />
+    <ProjectReference Include="..\MoBi.Engine\MoBi.Engine.csproj" />
+    <ProjectReference Include="..\MoBi.UI\MoBi.UI.csproj" />
   </ItemGroup>
-  <Import Project="$(MSBuildToolsPath)\Microsoft.CSharp.targets" />
-  <Import Project="..\..\packages\System.Data.SQLite.Core.1.0.110.0\build\net46\System.Data.SQLite.Core.targets" Condition="Exists('..\..\packages\System.Data.SQLite.Core.1.0.110.0\build\net46\System.Data.SQLite.Core.targets')" />
-  <Target Name="EnsureNuGetPackageBuildImports" BeforeTargets="PrepareForBuild">
-    <PropertyGroup>
-      <ErrorText>This project references NuGet package(s) that are missing on this computer. Use NuGet Package Restore to download them.  For more information, see http://go.microsoft.com/fwlink/?LinkID=322105. The missing file is {0}.</ErrorText>
-    </PropertyGroup>
-    <Error Condition="!Exists('..\..\packages\System.Data.SQLite.Core.1.0.110.0\build\net46\System.Data.SQLite.Core.targets')" Text="$([System.String]::Format('$(ErrorText)', '..\..\packages\System.Data.SQLite.Core.1.0.110.0\build\net46\System.Data.SQLite.Core.targets'))" />
-  </Target>
-  <!-- To modify your build process, add your task inside one of the targets below and uncomment it. 
-       Other similar extension points exist, see Microsoft.Common.targets.
-  <Target Name="BeforeBuild">
-  </Target>
-  <Target Name="AfterBuild">
-  </Target>
-  -->
+
 </Project>
\ No newline at end of file
diff --git a/src/MoBi.BatchTool/MoBi.ico b/src/MoBi.BatchTool/MoBi.ico
new file mode 100644
index 000000000..40e6aa14b
Binary files /dev/null and b/src/MoBi.BatchTool/MoBi.ico differ
diff --git a/src/MoBi.BatchTool/Properties/AssemblyInfo.cs b/src/MoBi.BatchTool/Properties/AssemblyInfo.cs
deleted file mode 100644
index 4af0a72c1..000000000
--- a/src/MoBi.BatchTool/Properties/AssemblyInfo.cs
+++ /dev/null
@@ -1,8 +0,0 @@
-using System.Reflection;
-
-// General Information about an assembly is controlled through the following 
-// set of attributes. Change these attribute values to modify the information
-// associated with an assembly.
-
-[assembly: AssemblyTitle("MoBi.BatchTool")]
-[assembly: AssemblyDescription("")]
\ No newline at end of file
diff --git a/src/MoBi.BatchTool/Properties/Resources.Designer.cs b/src/MoBi.BatchTool/Properties/Resources.Designer.cs
deleted file mode 100644
index a76f617f5..000000000
--- a/src/MoBi.BatchTool/Properties/Resources.Designer.cs
+++ /dev/null
@@ -1,63 +0,0 @@
-//------------------------------------------------------------------------------
-// <auto-generated>
-//     This code was generated by a tool.
-//     Runtime Version:4.0.30319.42000
-//
-//     Changes to this file may cause incorrect behavior and will be lost if
-//     the code is regenerated.
-// </auto-generated>
-//------------------------------------------------------------------------------
-
-namespace MoBi.BatchTool.Properties {
-    using System;
-    
-    
-    /// <summary>
-    ///   A strongly-typed resource class, for looking up localized strings, etc.
-    /// </summary>
-    // This class was auto-generated by the StronglyTypedResourceBuilder
-    // class via a tool like ResGen or Visual Studio.
-    // To add or remove a member, edit your .ResX file then rerun ResGen
-    // with the /str option, or rebuild your VS project.
-    [global::System.CodeDom.Compiler.GeneratedCodeAttribute("System.Resources.Tools.StronglyTypedResourceBuilder", "15.0.0.0")]
-    [global::System.Diagnostics.DebuggerNonUserCodeAttribute()]
-    [global::System.Runtime.CompilerServices.CompilerGeneratedAttribute()]
-    internal class Resources {
-        
-        private static global::System.Resources.ResourceManager resourceMan;
-        
-        private static global::System.Globalization.CultureInfo resourceCulture;
-        
-        [global::System.Diagnostics.CodeAnalysis.SuppressMessageAttribute("Microsoft.Performance", "CA1811:AvoidUncalledPrivateCode")]
-        internal Resources() {
-        }
-        
-        /// <summary>
-        ///   Returns the cached ResourceManager instance used by this class.
-        /// </summary>
-        [global::System.ComponentModel.EditorBrowsableAttribute(global::System.ComponentModel.EditorBrowsableState.Advanced)]
-        internal static global::System.Resources.ResourceManager ResourceManager {
-            get {
-                if (object.ReferenceEquals(resourceMan, null)) {
-                    global::System.Resources.ResourceManager temp = new global::System.Resources.ResourceManager("MoBi.BatchTool.Properties.Resources", typeof(Resources).Assembly);
-                    resourceMan = temp;
-                }
-                return resourceMan;
-            }
-        }
-        
-        /// <summary>
-        ///   Overrides the current thread's CurrentUICulture property for all
-        ///   resource lookups using this strongly typed resource class.
-        /// </summary>
-        [global::System.ComponentModel.EditorBrowsableAttribute(global::System.ComponentModel.EditorBrowsableState.Advanced)]
-        internal static global::System.Globalization.CultureInfo Culture {
-            get {
-                return resourceCulture;
-            }
-            set {
-                resourceCulture = value;
-            }
-        }
-    }
-}
diff --git a/src/MoBi.BatchTool/Properties/Resources.resx b/src/MoBi.BatchTool/Properties/Resources.resx
deleted file mode 100644
index af7dbebba..000000000
--- a/src/MoBi.BatchTool/Properties/Resources.resx
+++ /dev/null
@@ -1,117 +0,0 @@
-<?xml version="1.0" encoding="utf-8"?>
-<root>
-  <!-- 
-    Microsoft ResX Schema 
-    
-    Version 2.0
-    
-    The primary goals of this format is to allow a simple XML format 
-    that is mostly human readable. The generation and parsing of the 
-    various data types are done through the TypeConverter classes 
-    associated with the data types.
-    
-    Example:
-    
-    ... ado.net/XML headers & schema ...
-    <resheader name="resmimetype">text/microsoft-resx</resheader>
-    <resheader name="version">2.0</resheader>
-    <resheader name="reader">System.Resources.ResXResourceReader, System.Windows.Forms, ...</resheader>
-    <resheader name="writer">System.Resources.ResXResourceWriter, System.Windows.Forms, ...</resheader>
-    <data name="Name1"><value>this is my long string</value><comment>this is a comment</comment></data>
-    <data name="Color1" type="System.Drawing.Color, System.Drawing">Blue</data>
-    <data name="Bitmap1" mimetype="application/x-microsoft.net.object.binary.base64">
-        <value>[base64 mime encoded serialized .NET Framework object]</value>
-    </data>
-    <data name="Icon1" type="System.Drawing.Icon, System.Drawing" mimetype="application/x-microsoft.net.object.bytearray.base64">
-        <value>[base64 mime encoded string representing a byte array form of the .NET Framework object]</value>
-        <comment>This is a comment</comment>
-    </data>
-                
-    There are any number of "resheader" rows that contain simple 
-    name/value pairs.
-    
-    Each data row contains a name, and value. The row also contains a 
-    type or mimetype. Type corresponds to a .NET class that support 
-    text/value conversion through the TypeConverter architecture. 
-    Classes that don't support this are serialized and stored with the 
-    mimetype set.
-    
-    The mimetype is used for serialized objects, and tells the 
-    ResXResourceReader how to depersist the object. This is currently not 
-    extensible. For a given mimetype the value must be set accordingly:
-    
-    Note - application/x-microsoft.net.object.binary.base64 is the format 
-    that the ResXResourceWriter will generate, however the reader can 
-    read any of the formats listed below.
-    
-    mimetype: application/x-microsoft.net.object.binary.base64
-    value   : The object must be serialized with 
-            : System.Serialization.Formatters.Binary.BinaryFormatter
-            : and then encoded with base64 encoding.
-    
-    mimetype: application/x-microsoft.net.object.soap.base64
-    value   : The object must be serialized with 
-            : System.Runtime.Serialization.Formatters.Soap.SoapFormatter
-            : and then encoded with base64 encoding.
-
-    mimetype: application/x-microsoft.net.object.bytearray.base64
-    value   : The object must be serialized into a byte array 
-            : using a System.ComponentModel.TypeConverter
-            : and then encoded with base64 encoding.
-    -->
-  <xsd:schema id="root" xmlns="" xmlns:xsd="http://www.w3.org/2001/XMLSchema" xmlns:msdata="urn:schemas-microsoft-com:xml-msdata">
-    <xsd:element name="root" msdata:IsDataSet="true">
-      <xsd:complexType>
-        <xsd:choice maxOccurs="unbounded">
-          <xsd:element name="metadata">
-            <xsd:complexType>
-              <xsd:sequence>
-                <xsd:element name="value" type="xsd:string" minOccurs="0" />
-              </xsd:sequence>
-              <xsd:attribute name="name" type="xsd:string" />
-              <xsd:attribute name="type" type="xsd:string" />
-              <xsd:attribute name="mimetype" type="xsd:string" />
-            </xsd:complexType>
-          </xsd:element>
-          <xsd:element name="assembly">
-            <xsd:complexType>
-              <xsd:attribute name="alias" type="xsd:string" />
-              <xsd:attribute name="name" type="xsd:string" />
-            </xsd:complexType>
-          </xsd:element>
-          <xsd:element name="data">
-            <xsd:complexType>
-              <xsd:sequence>
-                <xsd:element name="value" type="xsd:string" minOccurs="0" msdata:Ordinal="1" />
-                <xsd:element name="comment" type="xsd:string" minOccurs="0" msdata:Ordinal="2" />
-              </xsd:sequence>
-              <xsd:attribute name="name" type="xsd:string" msdata:Ordinal="1" />
-              <xsd:attribute name="type" type="xsd:string" msdata:Ordinal="3" />
-              <xsd:attribute name="mimetype" type="xsd:string" msdata:Ordinal="4" />
-            </xsd:complexType>
-          </xsd:element>
-          <xsd:element name="resheader">
-            <xsd:complexType>
-              <xsd:sequence>
-                <xsd:element name="value" type="xsd:string" minOccurs="0" msdata:Ordinal="1" />
-              </xsd:sequence>
-              <xsd:attribute name="name" type="xsd:string" use="required" />
-            </xsd:complexType>
-          </xsd:element>
-        </xsd:choice>
-      </xsd:complexType>
-    </xsd:element>
-  </xsd:schema>
-  <resheader name="resmimetype">
-    <value>text/microsoft-resx</value>
-  </resheader>
-  <resheader name="version">
-    <value>2.0</value>
-  </resheader>
-  <resheader name="reader">
-    <value>System.Resources.ResXResourceReader, System.Windows.Forms, Version=2.0.0.0, Culture=neutral, PublicKeyToken=b77a5c561934e089</value>
-  </resheader>
-  <resheader name="writer">
-    <value>System.Resources.ResXResourceWriter, System.Windows.Forms, Version=2.0.0.0, Culture=neutral, PublicKeyToken=b77a5c561934e089</value>
-  </resheader>
-</root>
\ No newline at end of file
diff --git a/src/MoBi.BatchTool/Properties/Settings.Designer.cs b/src/MoBi.BatchTool/Properties/Settings.Designer.cs
deleted file mode 100644
index f6766ee1a..000000000
--- a/src/MoBi.BatchTool/Properties/Settings.Designer.cs
+++ /dev/null
@@ -1,26 +0,0 @@
-//------------------------------------------------------------------------------
-// <auto-generated>
-//     This code was generated by a tool.
-//     Runtime Version:4.0.30319.42000
-//
-//     Changes to this file may cause incorrect behavior and will be lost if
-//     the code is regenerated.
-// </auto-generated>
-//------------------------------------------------------------------------------
-
-namespace MoBi.BatchTool.Properties {
-    
-    
-    [global::System.Runtime.CompilerServices.CompilerGeneratedAttribute()]
-    [global::System.CodeDom.Compiler.GeneratedCodeAttribute("Microsoft.VisualStudio.Editors.SettingsDesigner.SettingsSingleFileGenerator", "15.3.0.0")]
-    internal sealed partial class Settings : global::System.Configuration.ApplicationSettingsBase {
-        
-        private static Settings defaultInstance = ((Settings)(global::System.Configuration.ApplicationSettingsBase.Synchronized(new Settings())));
-        
-        public static Settings Default {
-            get {
-                return defaultInstance;
-            }
-        }
-    }
-}
diff --git a/src/MoBi.BatchTool/Properties/Settings.settings b/src/MoBi.BatchTool/Properties/Settings.settings
deleted file mode 100644
index 39645652a..000000000
--- a/src/MoBi.BatchTool/Properties/Settings.settings
+++ /dev/null
@@ -1,7 +0,0 @@
-<?xml version='1.0' encoding='utf-8'?>
-<SettingsFile xmlns="http://schemas.microsoft.com/VisualStudio/2004/01/settings" CurrentProfile="(Default)">
-  <Profiles>
-    <Profile Name="(Default)" />
-  </Profiles>
-  <Settings />
-</SettingsFile>
diff --git a/src/MoBi.BatchTool/Properties/licenses.licx b/src/MoBi.BatchTool/Properties/licenses.licx
deleted file mode 100644
index e69de29bb..000000000
diff --git a/src/MoBi.BatchTool/Services/BatchDiagramModelToXmlMapper.cs b/src/MoBi.BatchTool/Services/BatchDiagramModelToXmlMapper.cs
index 479487d9e..5fce2a839 100644
--- a/src/MoBi.BatchTool/Services/BatchDiagramModelToXmlMapper.cs
+++ b/src/MoBi.BatchTool/Services/BatchDiagramModelToXmlMapper.cs
@@ -28,9 +28,6 @@ public void AddElementBaseNodeBindingFor<T>(T node)
 
       }
 
-      public string ElementName
-      {
-         get { return "DiagramModel"; }
-      }
+      public string ElementName => "DiagramModel";
    }
 }
\ No newline at end of file
diff --git a/src/MoBi.BatchTool/packages.config b/src/MoBi.BatchTool/packages.config
deleted file mode 100644
index 04a82229e..000000000
--- a/src/MoBi.BatchTool/packages.config
+++ /dev/null
@@ -1,49 +0,0 @@
-<?xml version="1.0" encoding="utf-8"?>
-<packages>
-  <package id="Antlr3.Runtime" version="3.5.1" targetFramework="net462" />
-  <package id="Castle.Core" version="4.3.1" targetFramework="net462" />
-  <package id="Castle.Windsor" version="4.1.1" targetFramework="net462" />
-  <package id="csmpfit" version="1.1.1" targetFramework="net462" />
-  <package id="Dapper" version="1.60.6" targetFramework="net462" />
-  <package id="FluentNHibernate" version="2.1.2" targetFramework="net462" />
-  <package id="Iesi.Collections" version="4.0.4" targetFramework="net462" />
-  <package id="MathNet.Numerics" version="4.7.0" targetFramework="net462" />
-  <package id="Microsoft.Extensions.Configuration" version="2.2.0" targetFramework="net462" />
-  <package id="Microsoft.Extensions.Configuration.Abstractions" version="2.2.0" targetFramework="net462" />
-  <package id="Microsoft.Extensions.Configuration.Binder" version="2.2.0" targetFramework="net462" />
-  <package id="Microsoft.Extensions.DependencyInjection.Abstractions" version="2.2.0" targetFramework="net462" />
-  <package id="Microsoft.Extensions.Logging" version="2.2.0" targetFramework="net462" />
-  <package id="Microsoft.Extensions.Logging.Abstractions" version="2.2.0" targetFramework="net462" />
-  <package id="Microsoft.Extensions.Options" version="2.2.0" targetFramework="net462" />
-  <package id="Microsoft.Extensions.Primitives" version="2.2.0" targetFramework="net462" />
-  <package id="Newtonsoft.Json" version="12.0.1" targetFramework="net462" />
-  <package id="NHibernate" version="5.2.5" targetFramework="net462" />
-  <package id="Northwoods.GoWin" version="5.2.0" targetFramework="net462" />
-  <package id="OSPSuite.Assets" version="8.0.4" targetFramework="net462" />
-  <package id="OSPSuite.Core" version="8.0.4" targetFramework="net462" />
-  <package id="OSPSuite.DataBinding" version="2.3.0.3" targetFramework="net462" />
-  <package id="OSPSuite.DataBinding.DevExpress" version="3.0.0.3" targetFramework="net462" />
-  <package id="OSPSuite.DevExpress" version="18.2.7" targetFramework="net462" />
-  <package id="OSPSuite.DevExpress.Presentation" version="18.2.7" targetFramework="net462" />
-  <package id="OSPSuite.FuncParser" version="3.0.1.14" targetFramework="net462" />
-  <package id="OSPSuite.Infrastructure" version="8.0.4" targetFramework="net462" />
-  <package id="OSPSuite.Presentation" version="8.0.4" targetFramework="net462" />
-  <package id="OSPSuite.Serializer" version="2.0.1.4" targetFramework="net462" />
-  <package id="OSPSuite.SimModel" version="3.0.1.27" targetFramework="net462" />
-  <package id="OSPSuite.SmartXLS" version="2.7.0.9" targetFramework="net462" />
-  <package id="OSPSuite.TeXReporting" version="2.1.1.9" targetFramework="net462" />
-  <package id="OSPSuite.UI" version="8.0.4" targetFramework="net462" />
-  <package id="OSPSuite.Utility" version="3.0.1.7" targetFramework="net462" />
-  <package id="Remotion.Linq" version="2.2.0" targetFramework="net462" />
-  <package id="Remotion.Linq.EagerFetching" version="2.2.0" targetFramework="net462" />
-  <package id="SharpZipLib" version="1.1.0" targetFramework="net462" />
-  <package id="System.Buffers" version="4.4.0" targetFramework="net462" />
-  <package id="System.ComponentModel.Annotations" version="4.5.0" targetFramework="net462" />
-  <package id="System.Data.SQLite.Core" version="1.0.110.0" targetFramework="net462" />
-  <package id="System.Memory" version="4.5.1" targetFramework="net462" />
-  <package id="System.Numerics.Vectors" version="4.4.0" targetFramework="net462" />
-  <package id="System.Runtime.CompilerServices.Unsafe" version="4.5.1" targetFramework="net462" />
-  <package id="System.ValueTuple" version="4.4.0" targetFramework="net462" />
-  <package id="WindowsAPICodePack-Core" version="1.1.2" targetFramework="net462" />
-  <package id="WindowsAPICodePack-Shell" version="1.1.1" targetFramework="net462" />
-</packages>
\ No newline at end of file
diff --git a/src/MoBi.Core/Commands/OutputIntervalInSimulationCommand.cs b/src/MoBi.Core/Commands/OutputIntervalInSimulationCommand.cs
index a1bf1b3bf..6cb788a74 100644
--- a/src/MoBi.Core/Commands/OutputIntervalInSimulationCommand.cs
+++ b/src/MoBi.Core/Commands/OutputIntervalInSimulationCommand.cs
@@ -22,7 +22,7 @@ protected OutputIntervalInSimulationCommand(OutputSchema schema, OutputInterval
       public override void RestoreExecutionData(IMoBiContext context)
       {
          base.RestoreExecutionData(context);
-         _schema = _simulation.Settings.OutputSchema;
+         _schema = _simulation.OutputSchema;
       }
 
       protected override void ClearReferences()
diff --git a/src/MoBi.Core/Commands/SetParameterDimensionInBuildingBlockCommand.cs b/src/MoBi.Core/Commands/SetParameterDimensionInBuildingBlockCommand.cs
index 59ad057da..53279a6d5 100644
--- a/src/MoBi.Core/Commands/SetParameterDimensionInBuildingBlockCommand.cs
+++ b/src/MoBi.Core/Commands/SetParameterDimensionInBuildingBlockCommand.cs
@@ -1,13 +1,14 @@
-using MoBi.Assets;
-using OSPSuite.Core.Commands.Core;
+using System;
+using MoBi.Assets;
 using MoBi.Core.Domain.Model;
 using MoBi.Core.Events;
+using OSPSuite.Assets;
+using OSPSuite.Core.Commands.Core;
 using OSPSuite.Core.Domain;
 using OSPSuite.Core.Domain.Builder;
 using OSPSuite.Core.Domain.Formulas;
 using OSPSuite.Core.Domain.UnitSystem;
 using OSPSuite.Core.Services;
-using OSPSuite.Assets;
 
 namespace MoBi.Core.Commands
 {
@@ -28,7 +29,7 @@ public SetParameterDimensionInBuildingBlockCommand(IParameter parameter, IDimens
          _oldDimension = parameter.Dimension;
          _oldDisplayUnit = _parameter.DisplayUnit;
          _newDisplayUnit = null;
-         ObjectType =ObjectTypes.Parameter;
+         ObjectType = ObjectTypes.Parameter;
          CommandType = AppConstants.Commands.EditCommand;
       }
 
@@ -39,17 +40,19 @@ protected override void ExecuteWith(IMoBiContext context)
          _parameter.Dimension = _newDimension;
          _parameter.DisplayUnit = _newDisplayUnit ?? displayUnitRetriever.PreferredUnitFor(_parameter);
 
-         updateFormulaDimension(_parameter.Formula, _newDimension, context);
-         updateFormulaDimension(_parameter.RHSFormula, context.DimensionFactory.RHSDimensionFor(_newDimension), context);
+         updateFormulaDimension(_parameter.Formula, () => _newDimension, context);
+
+         updateFormulaDimension(_parameter.RHSFormula, () => context.DimensionFactory.GetOrAddRHSDimensionFor(_newDimension), context);
 
          Description = AppConstants.Commands.SetParameterDimension(_parameter.EntityPath(), _oldDimension.Name, _newDimension.Name);
          context.PublishEvent(new QuantityChangedEvent(_parameter));
       }
 
-      private void updateFormulaDimension(IFormula formula, IDimension dimension, IMoBiContext context)
+      // Note": We use a function here to ensure that evaluation of RHSDimension is only performed if there is a RHS 
+      private void updateFormulaDimension(IFormula formula, Func<IDimension> dimensionRetriever, IMoBiContext context)
       {
          if (formula == null) return;
-         formula.Dimension = dimension;
+         formula.Dimension = dimensionRetriever();
          context.PublishEvent(new FormulaChangedEvent(_parameter.Formula));
       }
 
diff --git a/src/MoBi.Core/Commands/UpdateOutputSelectionsInSimulationCommand.cs b/src/MoBi.Core/Commands/UpdateOutputSelectionsInSimulationCommand.cs
index 13d49c7ea..fe2fa844e 100644
--- a/src/MoBi.Core/Commands/UpdateOutputSelectionsInSimulationCommand.cs
+++ b/src/MoBi.Core/Commands/UpdateOutputSelectionsInSimulationCommand.cs
@@ -32,7 +32,7 @@ protected override void ClearReferences()
       protected override void DoExecute(IMoBiContext context)
       {
          _oldOutputSelections = _simulation.OutputSelections;
-         _simulation.Settings.OutputSelections = _outputSelections;
+         _simulation.SimulationSettings.OutputSelections = _outputSelections;
          Description = AppConstants.Commands.UpdateOutputSelectionInSimulationDescription(_simulation.Name);
       }
    }
diff --git a/src/MoBi.Core/CoreRegister.cs b/src/MoBi.Core/CoreRegister.cs
index 9faf667d5..40cfb4cee 100644
--- a/src/MoBi.Core/CoreRegister.cs
+++ b/src/MoBi.Core/CoreRegister.cs
@@ -1,5 +1,4 @@
 using System.Collections.Generic;
-using MoBi.Assets;
 using MoBi.Core.Commands;
 using MoBi.Core.Domain.Comparison;
 using MoBi.Core.Domain.Model;
@@ -9,7 +8,6 @@
 using MoBi.Core.Helper;
 using MoBi.Core.Reporting;
 using MoBi.Core.Serialization.Converter;
-using MoBi.Core.Serialization.Converter.v3_5;
 using MoBi.Core.Services;
 using OSPSuite.Core;
 using OSPSuite.Core.Commands;
@@ -19,11 +17,10 @@
 using OSPSuite.Core.Domain.Services;
 using OSPSuite.Core.Domain.Services.ParameterIdentifications;
 using OSPSuite.Core.Domain.UnitSystem;
-using OSPSuite.Infrastructure.Reporting;
+using OSPSuite.FuncParser;
+using OSPSuite.Infrastructure.Export;
 using OSPSuite.Infrastructure.Serialization.ORM.History;
-using OSPSuite.Infrastructure.Services;
-using OSPSuite.Utility.Collections;
-using OSPSuite.Utility.Compression;
+using OSPSuite.Infrastructure.Reporting;
 using OSPSuite.Utility.Container;
 using IContainer = OSPSuite.Utility.Container.IContainer;
 using ReportingRegister = OSPSuite.TeXReporting.ReportingRegister;
@@ -59,21 +56,22 @@ public override void RegisterInContainer(IContainer container)
          container.Register<IMoBiDimensionFactory, IDimensionFactory, MoBiDimensionFactory>(LifeStyle.Singleton);
          container.Register<IObjectTypeResolver, ObjectTypeResolver>(LifeStyle.Singleton);
          container.Register<FormulaTypeCaptionRepository, FormulaTypeCaptionRepository>(LifeStyle.Singleton);
-         container.Register<IObjectBaseFactory, ObjectBaseFactory>(LifeStyle.Singleton);
          container.Register<IGroupRepository, GroupRepository>(LifeStyle.Singleton);
          container.Register<IClipboardManager, ClipboardManager>(LifeStyle.Singleton);
          container.Register<ICloneManager, CloneManagerForBuildingBlock>(LifeStyle.Singleton);
 
-         container.Register<ICompression, SharpLibCompression>();
-         container.Register<IStringCompression, StringCompression>();
          container.Register<IProjectRetriever, MoBiProjectRetriever>();
          container.Register<IHistoryManager, MoBiHistoryManager>();
          container.Register<IObjectIdResetter, ObjectIdResetter>();
          container.Register<ISetParameterTask, ParameterTask>();
          container.Register<ITransferOptimizedParametersToSimulationsTask, TransferOptimizedParametersToSimulationsTask<IMoBiContext>>();
 
+         //Register application specific core objects
+         container.Register<IObjectBaseFactory, ObjectBaseFactory>(LifeStyle.Singleton);
+         container.Register<IFullPathDisplayResolver, FullPathDisplayResolver>(LifeStyle.Singleton);
+
+
          //Register opened types generics
-         container.Register(typeof(IRepository<>), typeof(ImplementationRepository<>));
          container.Register(typeof(IEntitiesInBuildingBlockRetriever<>), typeof(EntitiesInBuildingBlockRetriever<>));
          container.Register<IList<IDimensionMergingInformation>, List<IDimensionMergingInformation>>(LifeStyle.Singleton);
 
@@ -81,6 +79,11 @@ public override void RegisterInContainer(IContainer container)
          container.RegisterFactory<IHistoryManagerFactory>();
          container.RegisterFactory<IDiagramManagerFactory>();
 
+
+         container.Register<DimensionParser, DimensionParser>();
+
+         registerSerializers(container);
+
          registerReporters(container);
 
          registerComparers(container);
@@ -90,16 +93,22 @@ public override void RegisterInContainer(IContainer container)
          registerConverters(container);
       }
 
+      private void registerSerializers(IContainer container)
+      {
+         container.AddRegister(x => x.FromType<OSPSuite.Infrastructure.Serialization.InfrastructureSerializationRegister>());
+      }
+
       private static void registerReporters(IContainer container)
       {
          container.AddRegister(x => x.FromType<ReportingRegister>());
-         container.AddRegister(x => x.FromType<OSPSuite.Infrastructure.Reporting.ReportingRegister>());
+         container.AddRegister(x => x.FromType<InfrastructureReportingRegister>());
+         container.AddRegister(x => x.FromType<InfrastructureExportRegister>());
 
          container.AddScanner(scan =>
          {
             scan.AssemblyContainingType<CoreRegister>();
             scan.IncludeNamespaceContainingType<ProjectReporter>();
-            scan.WithConvention<ReporterRegistrationConvention>();
+           scan.WithConvention<ReporterRegistrationConvention>();
          });
       }
 
@@ -129,8 +138,6 @@ private static void registerConverters(IContainer container)
          {
             scan.AssemblyContainingType<CoreRegister>();
             scan.IncludeNamespaceContainingType<IMoBiObjectConverter>();
-            //this one needs to be global because of required flag during conversion
-            scan.ExcludeType<Converter341To351>();
 
             scan.ExcludeType<MoBiObjectConverterFinder>();
             scan.ExcludeType<ProjectConverterLogger>();
@@ -140,7 +147,6 @@ private static void registerConverters(IContainer container)
          //Needs to be registered as singleton
          container.Register<IMoBiObjectConverterFinder, MoBiObjectConverterFinder>(LifeStyle.Singleton);
          container.Register<IProjectConverterLogger, ProjectConverterLogger>(LifeStyle.Singleton);
-         container.Register<IMoBiObjectConverter, Converter341To351>(LifeStyle.Singleton);
       }
    }
 }
\ No newline at end of file
diff --git a/src/MoBi.Core/Domain/Model/Diagram/MoBiBaseDiagramManager.cs b/src/MoBi.Core/Domain/Model/Diagram/MoBiBaseDiagramManager.cs
deleted file mode 100644
index 3f3c19728..000000000
--- a/src/MoBi.Core/Domain/Model/Diagram/MoBiBaseDiagramManager.cs
+++ /dev/null
@@ -1,15 +0,0 @@
-using SBSuite.Core.Diagram;
-using SBSuite.Core.Domain;
-using SBSuite.Presentation.Diagram;
-
-namespace MoBi.Core.Domain.Model.Diagram
-{
-
-   public interface IMoBiBaseDiagramManager : IBaseDiagramManager
-   {
-      void RenameObjectBase(IObjectBase objectBase);
-      void ApplyLayoutTemplate(IContainerBase containerBase, string diagramTemplateXmlFilePath, bool recursive);
-      void SaveContainerToXml(IContainerBase containerBase, string diagramTemplateXmlFilePath);
-      IDiagramModel LoadDiagramTemplate(string diagramTemplateXmlFilePath);
-   }
-}
\ No newline at end of file
diff --git a/src/MoBi.Core/Domain/Model/MoBiContext.cs b/src/MoBi.Core/Domain/Model/MoBiContext.cs
index 041166b11..3e54f9ed0 100644
--- a/src/MoBi.Core/Domain/Model/MoBiContext.cs
+++ b/src/MoBi.Core/Domain/Model/MoBiContext.cs
@@ -13,8 +13,7 @@
 using OSPSuite.Core.Domain.Services;
 using OSPSuite.Core.Domain.UnitSystem;
 using OSPSuite.Core.Extensions;
-using OSPSuite.Infrastructure;
-using OSPSuite.Infrastructure.Journal;
+using OSPSuite.Infrastructure.Serialization.Journal;
 using OSPSuite.Infrastructure.Serialization.ORM.History;
 using OSPSuite.Utility.Events;
 using OSPSuite.Utility.Extensions;
@@ -64,12 +63,13 @@ public class MoBiContext : Workspace<IMoBiProject>, IMoBiContext
       private readonly IObjectTypeResolver _objectTypeResolver;
       private readonly ICloneManagerForBuildingBlock _cloneManager;
       private readonly ILazyLoadTask _lazyLoadTask;
+      private readonly IJournalSession _journalSession;
 
       public IMoBiHistoryManager HistoryManager { get; set; }
       public IMoBiDimensionFactory DimensionFactory { get; }
       public IObjectBaseFactory ObjectBaseFactory { get; }
       public IObjectPathFactory ObjectPathFactory { get; }
-      public ICoreCalculationMethodRepository CalculatonMethodRepository { get; set; }
+      public ICoreCalculationMethodRepository CalculationMethodRepository { get; set; }
       public IEventPublisher EventPublisher { get; }
       public IWithIdRepository ObjectRepository { get; }
 
@@ -77,7 +77,7 @@ public MoBiContext(IObjectBaseFactory objectBaseFactory, IMoBiDimensionFactory d
          IXmlSerializationService serializationService, IObjectPathFactory objectPathFactory, IWithIdRepository objectBaseRepository,
          IHistoryManagerFactory historyManagerFactory, IRegisterTask registerTask, IUnregisterTask unregisterTask,
          IClipboardManager clipboardManager, IContainer container, IObjectTypeResolver objectTypeResolver,
-         ICloneManagerForBuildingBlock cloneManager, IJournalSession journalSession, IFileLocker fileLocker, ILazyLoadTask lazyLoadTask) : base(eventPublisher, journalSession, fileLocker)
+         ICloneManagerForBuildingBlock cloneManager, IJournalSession journalSession, IFileLocker fileLocker, ILazyLoadTask lazyLoadTask) : base(eventPublisher, fileLocker)
       {
          ObjectBaseFactory = objectBaseFactory;
          ObjectRepository = objectBaseRepository;
@@ -93,6 +93,7 @@ public MoBiContext(IObjectBaseFactory objectBaseFactory, IMoBiDimensionFactory d
          _registerTask = registerTask;
          _unregisterTask = unregisterTask;
          _clipboardManager = clipboardManager;
+         _journalSession = journalSession;
       }
 
       public IMoBiProject CurrentProject
@@ -156,10 +157,10 @@ public void NewProject()
 
       public override void Clear()
       {
-         DimensionFactory.ProjectFactory = null;
          HistoryManager = null;
          ObjectRepository.Clear();
          _clipboardManager.Clear();
+         _journalSession.Close();
          base.Clear();
       }
 
@@ -195,7 +196,6 @@ public T Resolve<T>()
 
       public void LoadFrom(IMoBiProject project)
       {
-         DimensionFactory.ProjectFactory = project.DimensionFactory;
          CurrentProject = project;
          _registerTask.Register(project);
       }
diff --git a/src/MoBi.Core/Domain/Model/MoBiProject.cs b/src/MoBi.Core/Domain/Model/MoBiProject.cs
index d677e1d2a..b673ac95d 100644
--- a/src/MoBi.Core/Domain/Model/MoBiProject.cs
+++ b/src/MoBi.Core/Domain/Model/MoBiProject.cs
@@ -14,7 +14,6 @@ namespace MoBi.Core.Domain.Model
 {
    public interface IMoBiProject : IProject
    {
-      IDimensionFactory DimensionFactory { get; set; }
       IReadOnlyList<IMoBiSimulation> Simulations { get; }
       IReadOnlyList<IMoleculeBuildingBlock> MoleculeBlockCollection { get; }
       IReadOnlyList<IMoBiReactionBuildingBlock> ReactionBlockCollection { get; }
@@ -29,7 +28,7 @@ public interface IMoBiProject : IProject
       ReactionDimensionMode ReactionDimensionMode { get; set; }
 
       void AddSimulation(IMoBiSimulation newSimulation);
-      void RemoveSimulation(IMoBiSimulation simualtionToRemove);
+      void RemoveSimulation(IMoBiSimulation simulationToRemove);
       void AddChart(CurveChart chart);
       void RemoveChart(CurveChart chartToRemove);
 
@@ -83,7 +82,6 @@ public class MoBiProject : Project, IMoBiProject
       private readonly List<IMoBiSimulation> _allSimulations;
 
       public string ChartSettings { get; set; }
-      public IDimensionFactory DimensionFactory { get; set; }
 
       public override bool HasChanged { get; set; }
 
@@ -93,7 +91,6 @@ public class MoBiProject : Project, IMoBiProject
 
       public MoBiProject()
       {
-         DimensionFactory = new MoBiMergedDimensionFactory();
          _charts = new List<CurveChart>();
          _buildingBlocks = new List<IBuildingBlock>();
          _allSimulations = new List<IMoBiSimulation>();
@@ -145,10 +142,10 @@ public void AddSimulation(IMoBiSimulation newSimulation)
          _allSimulations.Add(newSimulation);
       }
 
-      public void RemoveSimulation(IMoBiSimulation simualtionToRemove)
+      public void RemoveSimulation(IMoBiSimulation simulationToRemove)
       {
-         _allSimulations.Remove(simualtionToRemove);
-         RemoveClassifiableForWrappedObject(simualtionToRemove);
+         _allSimulations.Remove(simulationToRemove);
+         RemoveClassifiableForWrappedObject(simulationToRemove);
       }
 
       public void AddChart(CurveChart chart)
diff --git a/src/MoBi.Core/Domain/Model/MoBiSimulation.cs b/src/MoBi.Core/Domain/Model/MoBiSimulation.cs
index e1b9a3cf3..708ec36d5 100644
--- a/src/MoBi.Core/Domain/Model/MoBiSimulation.cs
+++ b/src/MoBi.Core/Domain/Model/MoBiSimulation.cs
@@ -11,8 +11,9 @@
 
 namespace MoBi.Core.Domain.Model
 {
-   public interface IMoBiSimulation : IModelCoreSimulation, IWithDiagramFor<IMoBiSimulation>, ISimulation, IWithChartTemplates
+   public interface IMoBiSimulation : IWithDiagramFor<IMoBiSimulation>, ISimulation, IWithChartTemplates
    {
+      DataRepository Results { get; set; }
       ICache<string, DataRepository> HistoricResults { get; }
       CurveChart Chart { get; set; }
       IMoBiBuildConfiguration MoBiBuildConfiguration { get; }
@@ -22,10 +23,9 @@ public interface IMoBiSimulation : IModelCoreSimulation, IWithDiagramFor<IMoBiSi
 
       SolverSettings Solver { get; }
       OutputSchema OutputSchema { get; }
-      ISimulationSettings Settings { get; }
 
       /// <summary>
-      ///    Returns true if the simulation as created using the <paramref name="templateBuildingBlock" /> otherwise fasle.
+      ///    Returns true if the simulation as created using the <paramref name="templateBuildingBlock" /> otherwise false.
       /// </summary>
       bool IsCreatedBy(IBuildingBlock templateBuildingBlock);
 
@@ -38,6 +38,7 @@ public class MoBiSimulation : ModelCoreSimulation, IMoBiSimulation
    {
       private bool _hasChanged;
       private readonly IList<ISimulationAnalysis> _allSimulationAnalyses = new List<ISimulationAnalysis>();
+      private DataRepository _results;
       public IDiagramModel DiagramModel { get; set; }
       public CurveChart Chart { get; set; }
       public string ParameterIdentificationWorkingDirectory { get; set; }
@@ -54,18 +55,16 @@ public bool HasChanged
          set => _hasChanged = value;
       }
 
-      public ISimulationSettings Settings => MoBiBuildConfiguration.SimulationSettings;
-
-      public OutputSchema OutputSchema => Settings.OutputSchema;
+      public OutputSchema OutputSchema => SimulationSettings.OutputSchema;
 
       public CurveChartTemplate ChartTemplateByName(string chartTemplate)
       {
-         return Settings.ChartTemplateByName(chartTemplate);
+         return SimulationSettings.ChartTemplateByName(chartTemplate);
       }
 
       public void RemoveAllChartTemplates()
       {
-         Settings.RemoveAllChartTemplates();
+         SimulationSettings.RemoveAllChartTemplates();
       }
 
       public bool IsCreatedBy(IBuildingBlock templateBuildingBlock)
@@ -73,7 +72,7 @@ public bool IsCreatedBy(IBuildingBlock templateBuildingBlock)
          return MoBiBuildConfiguration.BuildingInfoForTemplate(templateBuildingBlock) != null;
       }
 
-      public SolverSettings Solver => Settings.Solver;
+      public SolverSettings Solver => SimulationSettings.Solver;
 
       public bool UsesObservedData(DataRepository dataRepository)
       {
@@ -85,8 +84,6 @@ private static bool chartUsesObservedData(DataRepository dataRepository, CurveCh
          return curveChart != null && curveChart.Curves.Any(c => Equals(c.yData.Repository, dataRepository));
       }
 
-      public OutputSelections OutputSelections => Settings.OutputSelections;
-
       public override void AcceptVisitor(IVisitor visitor)
       {
          base.AcceptVisitor(visitor);
@@ -122,24 +119,12 @@ public override void UpdatePropertiesFrom(IUpdatable source, ICloneManager clone
          return null;
       }
 
-      /// <summary>
-      ///    Returns the endtime of the simulation in kernel unit
-      /// </summary>
-      public virtual double? EndTime
-      {
-         get { return OutputSchema.Intervals.Select(x => x.EndTime.Value).Max(); }
-      }
-
       public IEnumerable<CurveChart> Charts
       {
          get { yield return Chart; }
       }
 
-      public ISimulationSettings SimulationSettings => BuildConfiguration.SimulationSettings;
-
-      public IReadOnlyList<string> CompoundNames => BuildConfiguration.AllPresentMolecules().Select(x => x.Name).ToList();
-
-      public IReactionBuildingBlock Reactions
+      public new IReactionBuildingBlock Reactions
       {
          get => BuildConfiguration.Reactions;
          set => BuildConfiguration.Reactions = value;
@@ -185,22 +170,16 @@ public void MarkResultsOutOfDate()
 
       public bool HasResults => Results != null;
 
-      public override DataRepository Results
+      public DataRepository Results
       {
-         get => base.Results;
+         get => _results;
          set
          {
-            base.Results = value;
+            _results = value;
             HasUpToDateResults = true;
          }
       }
 
       public bool ComesFromPKSim => Creation.Origin == Origins.PKSim;
-
-      public IEnumerable<T> All<T>() where T : class, IEntity
-      {
-         var root = Model?.Root;
-         return root == null ? Enumerable.Empty<T>() : root.GetAllChildren<T>();
-      }
    }
 }
\ No newline at end of file
diff --git a/src/MoBi.Core/Domain/Services/DataNamingService.cs b/src/MoBi.Core/Domain/Services/DataNamingService.cs
index 3c34a0ad3..c312cad04 100644
--- a/src/MoBi.Core/Domain/Services/DataNamingService.cs
+++ b/src/MoBi.Core/Domain/Services/DataNamingService.cs
@@ -7,7 +7,7 @@
 
 namespace MoBi.Core.Domain.Services
 {
-   internal class DataNamingService : IDataNamingService
+   public class DataNamingService 
    {
       private readonly IMoBiContext _context;
 
diff --git a/src/MoBi.Core/Domain/UnitSystem/DimensionConverterFor.cs b/src/MoBi.Core/Domain/UnitSystem/DimensionConverter.cs
similarity index 91%
rename from src/MoBi.Core/Domain/UnitSystem/DimensionConverterFor.cs
rename to src/MoBi.Core/Domain/UnitSystem/DimensionConverter.cs
index efeefe6bd..a7adb2441 100644
--- a/src/MoBi.Core/Domain/UnitSystem/DimensionConverterFor.cs
+++ b/src/MoBi.Core/Domain/UnitSystem/DimensionConverter.cs
@@ -8,23 +8,23 @@
 
 namespace MoBi.Core.Domain.UnitSystem
 {
-   public interface IMoBiDimensionConverterFor : IDimensionConverterFor
+   public interface IMoBiDimensionConverter : IDimensionConverter
    {
       bool CanBeUsedFor(object refObject);
       void SetRefObject(object refObject);
    }
 
-   public interface IMoBiDimensionConverterFor<T> : IMoBiDimensionConverterFor where T : IWithDimension
+   public interface IMoBiDimensionConverter<T> : IMoBiDimensionConverter where T : IWithDimension
    {
       void SetRefObject(T refObject);
    }
 
-   public abstract class DimensionConverterFor<T> : IMoBiDimensionConverterFor<T> where T : IWithDimension
+   public abstract class DimensionConverter<T> : IMoBiDimensionConverter<T> where T : IWithDimension
    {
       private readonly IDimension _sourceDimension;
       private readonly IDimension _targetDimension;
 
-      protected DimensionConverterFor(IDimension sourceDimension, IDimension targetDimension)
+      protected DimensionConverter(IDimension sourceDimension, IDimension targetDimension)
       {
          _sourceDimension = sourceDimension;
          _targetDimension = targetDimension;
@@ -87,7 +87,7 @@ public bool CanConvertFrom(IDimension dimension)
       protected abstract double? GetFactor();
    }
 
-   public class MolWeightDimensionConverterForFormulaUsable : DimensionConverterFor<IQuantity>
+   public class MolWeightDimensionConverterForFormulaUsable : DimensionConverter<IQuantity>
    {
       private IQuantity _formulaUsable;
       private IObjectPath _useablePath;
@@ -131,7 +131,7 @@ public override void SetRefObject(IQuantity refObject)
    }
 
 
-   public abstract class MolWeightDimensionConverterForDataColumn : DimensionConverterFor<DataColumn>
+   public abstract class MolWeightDimensionConverterForDataColumn : DimensionConverter<DataColumn>
    {
       protected double? _mw;
 
diff --git a/src/MoBi.Core/Domain/UnitSystem/MoBiDimensionFactory.cs b/src/MoBi.Core/Domain/UnitSystem/MoBiDimensionFactory.cs
index 3c1b96df5..1f4c8df33 100644
--- a/src/MoBi.Core/Domain/UnitSystem/MoBiDimensionFactory.cs
+++ b/src/MoBi.Core/Domain/UnitSystem/MoBiDimensionFactory.cs
@@ -2,100 +2,18 @@
 using System.Collections.Generic;
 using System.Linq;
 using MoBi.Assets;
-using OSPSuite.Core.Domain;
 using OSPSuite.Core.Domain.UnitSystem;
 
 namespace MoBi.Core.Domain.UnitSystem
 {
    public interface IMoBiDimensionFactory : IDimensionFactory
    {
-      IDimensionFactory BaseFactory { get; }
-      IDimensionFactory ProjectFactory { get; set; }
-
-      /// <summary>
-      ///    Create the RHS Dimension for the given dimension and add it to the project factory
-      ///    if not available yet
-      /// </summary>
-      IDimension RHSDimensionFor(IDimension dimension);
-
-      /// <summary>
-      ///    Retrieve the dimension given a unit string
-      /// </summary>
-      /// <param name="unitName">The unit string that will be searched for. For example 'mg' or 's'</param>
-      /// <returns>The dimension associated with the unit name</returns>
-      IDimension DimensionForUnit(string unitName);
-
-      /// <summary>
-      ///    Returns the <see cref="IDimension" /> named <paramref name="dimensionName" /> or the default <c>NO_DIMENSION</c> if
-      ///    not found
-      /// </summary>
-      IDimension TryGetDimension(string dimensionName);
-
       IDimension TryGetDimensionCaseInsensitive(string dimensionName);
    }
 
-   public class MoBiDimensionFactory : IMoBiDimensionFactory
+   public class MoBiDimensionFactory : DimensionFactory, IMoBiDimensionFactory
    {
-      private IDimensionFactory _projectFactory;
-      public IDimensionFactory BaseFactory { get; }
-
-      public IDimensionFactory ProjectFactory
-      {
-         get => _projectFactory;
-         set => _projectFactory = value ?? new MoBiMergedDimensionFactory();
-      }
-
-      public IDimension DimensionForUnit(string unitName)
-      {
-         var matches = Dimensions.Where(dimension => dimension.Units.Any(unit => unitName.Equals(unit.Name, StringComparison.OrdinalIgnoreCase))).ToList();
-
-         if (!matches.Any())
-            return null;
-
-         return matches.Count() > 1
-            ? matches.FirstOrDefault(dimension => dimension.Units.Any(unit => unitName.Equals(unit.Name, StringComparison.Ordinal)))
-            : matches.First();
-      }
-
-      public MoBiDimensionFactory()
-      {
-         BaseFactory = new MoBiMergedDimensionFactory();
-         ProjectFactory = new MoBiMergedDimensionFactory();
-      }
-
-      public IDimension AddDimension(BaseDimensionRepresentation baseRepresentation, string dimensionName, string baseUnitName)
-      {
-         var newDim = new Dimension(baseRepresentation, dimensionName, baseUnitName);
-         AddDimension(newDim);
-         return newDim;
-      }
-
-      public void AddDimension(IDimension dimension)
-      {
-         ProjectFactory.AddDimension(dimension);
-      }
-
-      public IEnumerable<string> DimensionNames => Dimensions.Select(x => x.Name);
-
-      public IDimension Dimension(string name)
-      {
-         return
-            BaseFactory.TryGetDimension(name) ??
-            ProjectFactory.TryGetDimension(name) ??
-            rhsDimensionForName(name);
-      }
-
-      public IDimension TryGetDimension(string dimensionName)
-      {
-         try
-         {
-            return Dimension(dimensionName);
-         }
-         catch (KeyNotFoundException)
-         {
-            return NoDimension;
-         }
-      }
+      private IEnumerable<IMoBiDimensionMergingInformation> mobiDimensionMergingInformationList => AllMergingInformation.Cast<IMoBiDimensionMergingInformation>();
 
       public IDimension TryGetDimensionCaseInsensitive(string dimensionName)
       {
@@ -103,97 +21,36 @@ public IDimension TryGetDimensionCaseInsensitive(string dimensionName)
          return dimension ?? NoDimension;
       }
 
-      /// <summary>
-      ///    Try to find a dimension that could be the origin dimension for the given name
-      /// </summary>
-      /// <exception cref="KeyNotFoundException">is thrown when match could not be found</exception>
-      private IDimension rhsDimensionForName(string name)
-      {
-         if (string.IsNullOrEmpty(name))
-            throw new KeyNotFoundException();
-
-         if (!name.Contains(AppConstants.RHSDimensionSuffix))
-            throw new KeyNotFoundException(AppConstants.Exceptions.UnknownDimension(name));
-
-         var dimensionName = name.Replace(AppConstants.RHSDimensionSuffix, "");
-         var originDimension = Dimension(dimensionName);
-         return RHSDimensionFor(originDimension);
-      }
-
-      public void Clear()
-      {
-         /* nothing to do */
-      }
-
-      public void RemoveDimension(string dimensionName)
-      {
-         ProjectFactory.RemoveDimension(dimensionName);
-      }
-
-      public void RemoveDimension(IDimension dimension)
+      protected override IDimensionConverter CreateConverterFor<T>(IDimension dimension, IDimension dimensionToMerge, T hasDimension)
       {
-         RemoveDimension(dimension.Name);
-      }
-
-      public IDimension RHSDimensionFor(IDimension dimension)
-      {
-         var dimensionName = AppConstants.RHSDimensionName(dimension);
-         if (DimensionNames.Contains(dimensionName))
-            return Dimension(dimensionName);
-
-         var unitName = AppConstants.RHSDefaultUnitName(dimension);
+         var converter = (from mergeInfo in mobiDimensionMergingInformationList
+            where mergeInfo.Matches(dimension, dimensionToMerge, hasDimension)
+            select mergeInfo.Converter).SingleOrDefault();
 
-         // RHS is per Time hence -1
-         var rhsDimensionRepresentation = new BaseDimensionRepresentation(dimension.BaseRepresentation);
-         rhsDimensionRepresentation.TimeExponent = rhsDimensionRepresentation.TimeExponent - 1;
-
-         var rhsDimension = new Dimension(rhsDimensionRepresentation, dimensionName, unitName);
-         var equivalentRHSDimension = findFirstEquivalentDimension(rhsDimension, unitName);
-         if (equivalentRHSDimension != null)
-            return equivalentRHSDimension;
-
-         AddDimension(rhsDimension);
-         return rhsDimension;
-      }
-
-      private IDimension findFirstEquivalentDimension(Dimension rhsDimension, string unitName)
-      {
-         var equivalentRHSDimension = Dimensions.FirstOrDefault(x => x.IsEquivalentTo(rhsDimension));
-         if (equivalentRHSDimension != null && equivalentRHSDimension.HasUnit(unitName))
-            return equivalentRHSDimension;
-
-         return null;
-      }
+         if (converter == null)
+            return null;
 
-      public IEnumerable<IDimension> Dimensions
-      {
-         get
+         var usedConverter = Activator.CreateInstance(converter.GetType(), dimension, dimensionToMerge) as IMoBiDimensionConverter<T>;
+         if (usedConverter != null)
          {
-            var dimensions = BaseFactory.Dimensions
-               .Union(ProjectFactory.Dimensions);
-
-            return dimensions.OrderBy(dim => dim.DisplayName);
+            usedConverter.SetRefObject(hasDimension);
+            return usedConverter;
          }
-      }
 
-      public IDimension NoDimension => Dimension(Constants.Dimension.DIMENSIONLESS);
+         return converter;
+      }
 
-      public IDimension MergedDimensionFor<T>(T hasDimension) where T : IWithDimension
+      public override string MergedDimensionNameFor(IDimension sourceDimension)
       {
-         if (hasDimension.Dimension == null)
-            return null;
-
-         var dim = BaseFactory.MergedDimensionFor(hasDimension);
-
-         if (!Equals(dim, hasDimension.Dimension))
-            return dim;
+         if (isConcentration(sourceDimension))
+            return AppConstants.Captions.Concentration;
 
-         return ProjectFactory.MergedDimensionFor(hasDimension);
+         return base.MergedDimensionNameFor(sourceDimension);
       }
 
-      public void AddMergingInformation(IDimensionMergingInformation mergingInforamtion)
+      private bool isConcentration(IDimension dimension)
       {
-         ProjectFactory.AddMergingInformation(mergingInforamtion);
+         return dimension.Name.Contains(AppConstants.Captions.Concentration);
       }
    }
 }
\ No newline at end of file
diff --git a/src/MoBi.Core/Domain/UnitSystem/MoBiMergedDimensionFactory.cs b/src/MoBi.Core/Domain/UnitSystem/MoBiMergedDimensionFactory.cs
index 3113cc3b1..d533c94d0 100644
--- a/src/MoBi.Core/Domain/UnitSystem/MoBiMergedDimensionFactory.cs
+++ b/src/MoBi.Core/Domain/UnitSystem/MoBiMergedDimensionFactory.cs
@@ -1,51 +1,11 @@
-using System;
-using System.Collections.Generic;
-using System.Linq;
-using MoBi.Assets;
-using OSPSuite.Core.Domain;
+using OSPSuite.Core.Domain;
 using OSPSuite.Core.Domain.UnitSystem;
 
 namespace MoBi.Core.Domain.UnitSystem
 {
-   public class MoBiMergedDimensionFactory : DimensionFactory
-   {
-      private IEnumerable<IMoBiDimensionMergingInformation> mobiDimensionMergingInformationList => AllMergingInformation.Cast<IMoBiDimensionMergingInformation>();
-
-      protected override IDimensionConverterFor CreateConverterFor<T>(IDimension dimension, IDimension dimensionToMerge, T hasDimension)
-      {
-         var converter = (from mergeInfo in mobiDimensionMergingInformationList
-            where mergeInfo.Matches(dimension, dimensionToMerge, hasDimension)
-            select mergeInfo.Converter).SingleOrDefault();
-
-         if (converter == null)
-            return null;
-         
-         var usedConverter = Activator.CreateInstance(converter.GetType(), dimension, dimensionToMerge) as IMoBiDimensionConverterFor<T>;
-         if (usedConverter != null)
-         {
-            usedConverter.SetRefObject(hasDimension);
-            return usedConverter;
-         }
-         return converter;
-      }
-
-      public override string MergedDimensionNameFor(IDimension sourceDimension)
-      {
-         if (isConcentration(sourceDimension))
-            return AppConstants.Captions.Concentration;
-
-         return base.MergedDimensionNameFor(sourceDimension);
-      }
-
-      private bool isConcentration(IDimension dimension)
-      {
-         return dimension.Name.Contains(AppConstants.Captions.Concentration);
-      }
-   }
-
    public interface IMoBiDimensionMergingInformation : IDimensionMergingInformation
    {
-      IMoBiDimensionConverterFor Converter { get; }
+      IMoBiDimensionConverter Converter { get; }
       bool Matches(IDimension sourceDimension, IDimension targetDimension, IWithDimension withDimension);
    }
 
@@ -53,16 +13,16 @@ public class MoBiDimensionMergingInformation<T> : IMoBiDimensionMergingInformati
    {
       public IDimension SourceDimension { get; private set; }
       public IDimension TargetDimension { get; private set; }
-      public IMoBiDimensionConverterFor Converter { get; private set; }
+      public IMoBiDimensionConverter Converter { get; private set; }
+
       public bool Matches(IDimension sourceDimension, IDimension targetDimension, IWithDimension withDimension)
       {
          return SourceDimension.Equals(sourceDimension) &&
                 TargetDimension.Equals(targetDimension) &&
                 Converter.CanBeUsedFor(withDimension);
-
       }
 
-      public MoBiDimensionMergingInformation(IDimension sourceDimension, IDimension targetDimension, IMoBiDimensionConverterFor<T> converter)
+      public MoBiDimensionMergingInformation(IDimension sourceDimension, IDimension targetDimension, IMoBiDimensionConverter<T> converter)
       {
          SourceDimension = sourceDimension;
          TargetDimension = targetDimension;
diff --git a/src/MoBi.Core/Exceptions/MoBiException.cs b/src/MoBi.Core/Exceptions/MoBiException.cs
index f2bc0b3a5..429099a0f 100644
--- a/src/MoBi.Core/Exceptions/MoBiException.cs
+++ b/src/MoBi.Core/Exceptions/MoBiException.cs
@@ -34,7 +34,8 @@ public NotMatchingSerializationFileException(string searchedElement) :
          base(AppConstants.Exceptions.NoInformationFoundException(searchedElement))
       {
       }
-      public NotMatchingSerializationFileException(string fileName,string searchedElement, string foundElement) :
+
+      public NotMatchingSerializationFileException(string fileName, string searchedElement, string foundElement) :
          base(AppConstants.Exceptions.NoInformationFoundException(fileName, searchedElement, foundElement))
       {
       }
@@ -43,7 +44,7 @@ public NotMatchingSerializationFileException(string fileName,string searchedElem
    public class InvalidProjectFileException : MoBiException
    {
       public InvalidProjectFileException(int projectVersion)
-         : base(AppConstants.ProjectVersionCannotBeLoaded(projectVersion, ProjectVersions.Current,AppConstants.ProductSiteDownload))
+         : base(AppConstants.ProjectVersionCannotBeLoaded(projectVersion, ProjectVersions.Current, ProjectVersions.ProjectIsTooOld(projectVersion), AppConstants.ProductSiteDownload))
       {
       }
    }
diff --git a/src/MoBi.Core/Extensions/DimensionInfoExtensions.cs b/src/MoBi.Core/Extensions/DimensionInfoExtensions.cs
new file mode 100644
index 000000000..720ef11a6
--- /dev/null
+++ b/src/MoBi.Core/Extensions/DimensionInfoExtensions.cs
@@ -0,0 +1,18 @@
+using OSPSuite.FuncParser;
+namespace MoBi.Core.Extensions
+{
+
+   public static class DimensionInfoExtensions
+   {
+      public static bool AreEquals(this DimensionInformation left, DimensionInformation right)
+      {
+         return (left.LengthExponent == right.LengthExponent
+                 && left.MassExponent == right.MassExponent
+                 && left.TimeExponent == right.TimeExponent
+                 && left.ElectricCurrentExponent == right.ElectricCurrentExponent
+                 && left.TemperatureExponent == right.TemperatureExponent
+                 && left.AmountExponent == right.AmountExponent
+                 && left.LuminousIntensityExponent == right.LuminousIntensityExponent);
+      }
+   }
+}
\ No newline at end of file
diff --git a/src/MoBi.Core/MoBi.Core.csproj b/src/MoBi.Core/MoBi.Core.csproj
index a4d42b006..dfebf5ef8 100644
--- a/src/MoBi.Core/MoBi.Core.csproj
+++ b/src/MoBi.Core/MoBi.Core.csproj
@@ -1,678 +1,55 @@
-<?xml version="1.0" encoding="utf-8"?>
-<Project ToolsVersion="12.0" DefaultTargets="Build" xmlns="http://schemas.microsoft.com/developer/msbuild/2003">
+<Project Sdk="Microsoft.NET.Sdk">
+
   <PropertyGroup>
-    <Configuration Condition=" '$(Configuration)' == '' ">Debug</Configuration>
-    <Platform Condition=" '$(Platform)' == '' ">AnyCPU</Platform>
-    <ProductVersion>9.0.21022</ProductVersion>
-    <SchemaVersion>2.0</SchemaVersion>
-    <ProjectGuid>{2DBF50BE-A749-421C-B526-8BDA31CFE7B3}</ProjectGuid>
-    <OutputType>Library</OutputType>
-    <AppDesignerFolder>Properties</AppDesignerFolder>
-    <RootNamespace>MoBi.Core</RootNamespace>
-    <AssemblyName>MoBi.Core</AssemblyName>
-    <TargetFrameworkVersion>v4.6.2</TargetFrameworkVersion>
-    <FileAlignment>512</FileAlignment>
-    <SccProjectName>
-    </SccProjectName>
-    <SccLocalPath>
-    </SccLocalPath>
-    <SccAuxPath>
-    </SccAuxPath>
-    <SccProvider>
-    </SccProvider>
-    <FileUpgradeFlags>
-    </FileUpgradeFlags>
-    <UpgradeBackupLocation>
-    </UpgradeBackupLocation>
-    <OldToolsVersion>3.5</OldToolsVersion>
-    <TargetFrameworkProfile />
-    <NuGetPackageImportStamp>
-    </NuGetPackageImportStamp>
-  </PropertyGroup>
-  <PropertyGroup Condition=" '$(Configuration)|$(Platform)' == 'Debug|AnyCPU' ">
-    <DebugSymbols>true</DebugSymbols>
-    <DebugType>full</DebugType>
-    <Optimize>false</Optimize>
-    <OutputPath>bin\Debug\</OutputPath>
-    <DefineConstants>DEBUG;TRACE</DefineConstants>
-    <ErrorReport>prompt</ErrorReport>
-    <WarningLevel>4</WarningLevel>
-    <DocumentationFile>bin\Debug\MoBi.Core.XML</DocumentationFile>
+    <TargetFramework>net472</TargetFramework>
+    <Version>9.0.0</Version>
+    <PackageVersion>9.0.0</PackageVersion>
+    <AssemblyVersion>9.0.0</AssemblyVersion>
+    <FileVersion>9.0.0</FileVersion>
+    <InformationalVersion>9.0.0</InformationalVersion>
+    <GenerateAssemblyProductAttribute>false</GenerateAssemblyProductAttribute>
+    <GenerateAssemblyCompanyAttribute>false</GenerateAssemblyCompanyAttribute>
+    <PackageTags>open-systems-pharmacology, ospsuite-components</PackageTags>
+    <Description>Core functionalities for PK-Sim</Description>
+    <Authors>Open-Systems-Pharmacology</Authors>
+    <PackageLicenseFile>LICENSE</PackageLicenseFile>
+    <OutputPath>bin\$(Configuration)</OutputPath>
+    <DocumentationFile>bin\$(Configuration)\$(TargetFramework)\PKSim.Core.xml</DocumentationFile>
     <NoWarn>1591</NoWarn>
-    <Prefer32Bit>false</Prefer32Bit>
-    <PlatformTarget>AnyCPU</PlatformTarget>
-  </PropertyGroup>
-  <PropertyGroup Condition=" '$(Configuration)|$(Platform)' == 'Release|AnyCPU' ">
-    <DebugType>pdbonly</DebugType>
-    <Optimize>true</Optimize>
-    <OutputPath>bin\Release\</OutputPath>
-    <DefineConstants>TRACE</DefineConstants>
-    <ErrorReport>prompt</ErrorReport>
-    <WarningLevel>4</WarningLevel>
-    <Prefer32Bit>false</Prefer32Bit>
+
   </PropertyGroup>
+
   <ItemGroup>
-    <Reference Include="Antlr3.Runtime, Version=3.5.0.2, Culture=neutral, PublicKeyToken=eb42632606e9261f, processorArchitecture=MSIL">
-      <HintPath>..\..\packages\Antlr3.Runtime.3.5.1\lib\net40-client\Antlr3.Runtime.dll</HintPath>
-    </Reference>
-    <Reference Include="Castle.Core, Version=4.0.0.0, Culture=neutral, PublicKeyToken=407dd0808d44fbdc, processorArchitecture=MSIL">
-      <HintPath>..\..\packages\Castle.Core.4.3.1\lib\net45\Castle.Core.dll</HintPath>
-    </Reference>
-    <Reference Include="Castle.Windsor, Version=4.0.0.0, Culture=neutral, PublicKeyToken=407dd0808d44fbdc, processorArchitecture=MSIL">
-      <HintPath>..\..\packages\Castle.Windsor.4.1.1\lib\net45\Castle.Windsor.dll</HintPath>
-    </Reference>
-    <Reference Include="Dapper, Version=1.60.0.0, Culture=neutral, processorArchitecture=MSIL">
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+    <Compile Include="..\..\SolutionInfo.cs" Link="Properties\SolutionInfo.cs" />
   </ItemGroup>
+
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-    <Compile Include="Serialization\ORM\Mappers\ProjectMetaDataToProjectMapper.cs" />
-    <Compile Include="Serialization\ORM\Mappers\ProjectToProjectMetaDataMapper.cs" />
-    <Compile Include="Serialization\ORM\Mapping\DataRepositoryMetaDataMapping.cs" />
-    <Compile Include="Serialization\ORM\Mapping\EntityMetaDataMapping.cs" />
-    <Compile Include="Serialization\ORM\Mapping\SimulationMetaDataMapping.cs" />
-    <Compile Include="Serialization\ORM\MetaData\DataRepositoryMetaData.cs" />
-    <Compile Include="Serialization\ORM\MetaData\EntityMetaData.cs" />
-    <Compile Include="Serialization\ORM\MetaData\SimulationMetaData.cs" />
-    <Compile Include="Serialization\Converter\MoBiObjectConverterFinder.cs" />
-    <Compile Include="Serialization\Converter\IMoBiObjectConverter.cs" />
-    <Compile Include="Serialization\Converter\v3_1\Converter30To313.cs" />
-    <Compile Include="Serialization\Converter\v3_1\ModelUpdater.cs" />
-    <Compile Include="Serialization\Converter\v3_1\SpatialStructureUpdater.cs" />
-    <Compile Include="Serialization\Converter\v3_1\ParameterStartValueDimensionRetriever.cs" />
-    <Compile Include="Serialization\Converter\ProjectConverterMessage.cs" />
-    <Compile Include="Serialization\Xml\Serializer\BuildingBlockInfoXmlSerializer.cs" />
-    <Compile Include="Serialization\Xml\Serializer\ChartOptionsXmlSerializer.cs" />
-    <Compile Include="Serialization\Xml\Serializer\MergedDimensionFactorySerializer.cs" />
-    <Compile Include="Serialization\Xml\Services\CalculationMethodsRepositoryPersistor.cs" />
-    <Compile Include="Serialization\Xml\Services\IXmlContentSelector.cs" />
-    <Compile Include="Serialization\Services\SerializationContextFactory.cs" />
-    <Compile Include="Services\AdjustFormulaVisitor.cs" />
-    <Compile Include="Services\BuildingBlockRetriever.cs" />
-    <Compile Include="Services\CreateCommitChangesToBuildingBlockCommandTaskRetriever.cs" />
-    <Compile Include="Services\CreateCommitChangesToObserverBuildingBlockCommandTask.cs" />
-    <Compile Include="Services\ForbiddenNamesRetriever.cs" />
-    <Compile Include="Services\CreateCommitChangesToMoleculeStartValuesBuildingBlockCommandTask.cs" />
-    <Compile Include="Services\IDiagramModelToImageTask.cs" />
-    <Compile Include="Services\IMergeTask.cs" />
-    <Compile Include="Services\ISimulationRunner.cs" />
-    <Compile Include="Services\IOutputSelectionsRetriever.cs" />
-    <Compile Include="Services\MoleculeAmountTask.cs" />
-    <Compile Include="Properties\AssemblyInfo.cs" />
-    <Compile Include="Domain\Model\MoBiSimulation.cs" />
-    <Compile Include="Serialization\ORM\IPersitor.cs" />
-    <Compile Include="Serialization\ORM\Mapping\CommandMetaDataMapping.cs" />
-    <Compile Include="Serialization\ORM\Mapping\MetaDataContentMapping.cs" />
-    <Compile Include="Serialization\ORM\Mapping\HistoryItemMetaDataMapping.cs" />
-    <Compile Include="Serialization\ORM\MetaData\ProjectMetaData.cs" />
-    <Compile Include="Serialization\ORM\Mapping\ProjectMetaDataMapping.cs" />
-    <Compile Include="Serialization\ORM\ProjectPersistor.cs" />
-    <Compile Include="Serialization\ORM\SessionFactoryProvider.cs" />
-    <Compile Include="Serialization\PlugIns\IMoBiImExport.cs" />
-    <Compile Include="Serialization\ScampImportExport\ScampConstants.cs" />
-    <Compile Include="Serialization\Xml\Serializer\MoBiBuildConfigurationXmlSerializer.cs" />
-    <Compile Include="Serialization\Xml\Serializer\MoBiSimulationXmlSerializer.cs" />
-    <Compile Include="Serialization\Xml\Serializer\MoBiReactionBuildingBlockXmlSerializer.cs" />
-    <Compile Include="Serialization\Xml\Serializer\MoBiSpatialStructureXmlSerializer.cs" />
-    <Compile Include="Serialization\Xml\Services\XmlSerializationService.cs" />
-    <Compile Include="Serialization\Xml\XmlLinqConversionExtensions.cs" />
-    <Compile Include="Serialization\Xml\SerializationConstants.cs" />
-    <Compile Include="Serialization\Xml\Serializer\MoBiProjectXmlSerializer.cs" />
-    <Compile Include="Services\NameCorrector.cs" />
-    <Compile Include="Mappers\BuildConfigurationToMoBiBuildconfigurationMapper.cs" />
-    <Compile Include="Services\PendingChangesChecker.cs" />
-    <Compile Include="Services\ProjectFileCompressor.cs" />
-    <Compile Include="Services\QuantityTask.cs" />
-    <Compile Include="Services\SearchOptions.cs" />
-    <Compile Include="Services\SearchVisitor.cs" />
-    <Compile Include="Services\ClipboardManager.cs" />
-    <Compile Include="Services\ISearchResults.cs" />
-    <Compile Include="Services\SimulationPersistableUpdater.cs" />
-    <Compile Include="ValidationSettings.cs" />
-    <Compile Include="XmlHelper.cs" />
+    <Folder Include="Properties\" />
   </ItemGroup>
+
   <ItemGroup>
-    <ProjectReference Include="..\MoBi.Assets\MoBi.Assets.csproj">
-      <Project>{3C65FFC2-D9EC-4951-8C35-04854AD34E52}</Project>
-      <Name>MoBi.Assets</Name>
-    </ProjectReference>
+    <PackageReference Include="FluentNHibernate" Version="2.1.2" />
+    <PackageReference Include="Newtonsoft.Json" Version="12.0.3" />
+    <PackageReference Include="OSPSuite.Utility" Version="4.0.0.4" />
+    <PackageReference Include="OSPSuite.Core" Version="9.0.137" />
+    <PackageReference Include="OSPSuite.Assets" Version="9.0.137" />
+    <PackageReference Include="OSPSuite.Assets.Images" Version="9.0.137" />
+    <PackageReference Include="OSPSuite.Infrastructure.Export" Version="9.0.137" />
+    <PackageReference Include="OSPSuite.Infrastructure.Reporting" Version="9.0.137" />
+    <PackageReference Include="OSPSuite.Infrastructure.Serialization" Version="9.0.137" />
+    <PackageReference Include="OSPSuite.Infrastructure.Import" Version="9.0.137" />
+    <PackageReference Include="System.ComponentModel.Annotations" Version="4.7.0" />
   </ItemGroup>
+
   <ItemGroup>
-    <Folder Include="Serialization\Xml\Transfer\" />
+    <None Include="..\..\LICENSE">
+      <Pack>True</Pack>
+      <PackagePath></PackagePath>
+    </None>
   </ItemGroup>
+
   <ItemGroup>
-    <None Include="app.config">
-      <SubType>Designer</SubType>
-    </None>
-    <None Include="MoBi.Core.ncrunchproject" />
-    <None Include="packages.config" />
+    <ProjectReference Include="..\MoBi.Assets\MoBi.Assets.csproj" />
   </ItemGroup>
-  <Import Project="$(MSBuildToolsPath)\Microsoft.CSharp.targets" />
-  <Import Project="..\..\packages\System.Data.SQLite.Core.1.0.110.0\build\net46\System.Data.SQLite.Core.targets" Condition="Exists('..\..\packages\System.Data.SQLite.Core.1.0.110.0\build\net46\System.Data.SQLite.Core.targets')" />
-  <Target Name="EnsureNuGetPackageBuildImports" BeforeTargets="PrepareForBuild">
-    <PropertyGroup>
-      <ErrorText>This project references NuGet package(s) that are missing on this computer. Use NuGet Package Restore to download them.  For more information, see http://go.microsoft.com/fwlink/?LinkID=322105. The missing file is {0}.</ErrorText>
-    </PropertyGroup>
-    <Error Condition="!Exists('..\..\packages\System.Data.SQLite.Core.1.0.110.0\build\net46\System.Data.SQLite.Core.targets')" Text="$([System.String]::Format('$(ErrorText)', '..\..\packages\System.Data.SQLite.Core.1.0.110.0\build\net46\System.Data.SQLite.Core.targets'))" />
-  </Target>
-  <!-- To modify your build process, add your task inside one of the targets below and uncomment it. 
-       Other similar extension points exist, see Microsoft.Common.targets.
-  <Target Name="BeforeBuild">
-  </Target>
-  <Target Name="AfterBuild">
-  </Target>
-  -->
-</Project>
\ No newline at end of file
+
+</Project>
diff --git a/src/MoBi.Core/MoBiConfiguration.cs b/src/MoBi.Core/MoBiConfiguration.cs
index 3908858af..a6fc89c7a 100644
--- a/src/MoBi.Core/MoBiConfiguration.cs
+++ b/src/MoBi.Core/MoBiConfiguration.cs
@@ -4,7 +4,6 @@
 using MoBi.Assets;
 using OSPSuite.Core;
 using OSPSuite.Core.Domain;
-using OSPSuite.Infrastructure.Configuration;
 using OSPSuite.Assets;
 
 namespace MoBi.Core
@@ -26,7 +25,7 @@ public class MoBiConfiguration : OSPSuiteConfiguration, IMoBiConfiguration
       public override string ProductName { get; } = AppConstants.PRODUCT_NAME;
       public override Origin Product { get; } = Origins.MoBi;
       public override string ProductNameWithTrademark { get; } = AppConstants.PRODUCT_NAME_WITH_TRADEMARK;
-      public override ApplicationIcon Icon { get; } = ApplicationIcons.MoBi;
+      public override string IconName { get; } = ApplicationIcons.MoBi.IconName;
       protected override string[] LatestVersionWithOtherMajor { get; } = {"7.4", "6.3", "3.6" };
       public override string UserSettingsFileName { get; } = "Settings.xml";
       public override string ApplicationSettingsFileName { get; } = "ApplicationSettings.xml";
diff --git a/src/MoBi.Core/ProjectVersions.cs b/src/MoBi.Core/ProjectVersions.cs
index e1e06eb6d..ac2136101 100644
--- a/src/MoBi.Core/ProjectVersions.cs
+++ b/src/MoBi.Core/ProjectVersions.cs
@@ -8,23 +8,17 @@ public static class ProjectVersions
    {
       private static readonly Cache<int, ProjectVersion> _knownVersions = new Cache<int, ProjectVersion>(x => x.Version);
 
-      //Version 3.0.1 to 3.0.3
-      public static readonly ProjectVersion V3_0_1_to_3 = addVersion(0, "3.0.1");
-
-      public static readonly ProjectVersion V3_0_4 = addVersion(1, "3.0.4");
-      public static readonly ProjectVersion V3_1_3 = addVersion(2, "3.1.3");
-      public static readonly ProjectVersion V3_2_1 = addVersion(3, "3.2.1");
-      public static readonly ProjectVersion V3_3_1 = addVersion(PKMLVersion.V5_3_1, "3.3.1");
-      public static readonly ProjectVersion V3_4_1 = addVersion(PKMLVersion.V5_4_1, "3.4.1");
-      public static readonly ProjectVersion V3_5_1 = addVersion(PKMLVersion.V5_5_1, "3.5.1");
-      public static readonly ProjectVersion V3_6_1 = addVersion(PKMLVersion.V5_6_1, "3.3.1");
+      public const int UNSUPPORTED = PKMLVersion.NON_CONVERTABLE_VERSION;
+      // older versions not supported anymore starting V9
+
       public static readonly ProjectVersion V6_0_1 = addVersion(PKMLVersion.V6_0_1, "6.0.1");
       public static readonly ProjectVersion V6_1_1 = addVersion(PKMLVersion.V6_1_1, "6.1.1");
       public static readonly ProjectVersion V6_2_1 = addVersion(PKMLVersion.V6_2_1, "6.2.1");
       public static readonly ProjectVersion V6_3_1 = addVersion(PKMLVersion.V6_3_1, "6.3.1");
       public static readonly ProjectVersion V7_1_0 = addVersion(PKMLVersion.V7_1_0, "7.1.0");
       public static readonly ProjectVersion V7_3_0 = addVersion(PKMLVersion.V7_3_0, "7.3.0");
-      public static readonly ProjectVersion Current = V7_3_0;
+      public static readonly ProjectVersion V9_0 = addVersion(PKMLVersion.V9_0, "9.0");
+      public static readonly ProjectVersion Current = V9_0;
 
       private static ProjectVersion addVersion(int versionNumber, string versionDisplay)
       {
@@ -40,9 +34,11 @@ public static bool CanLoadVersion(int projectVersion)
          return (projectVersion <= Current.Version) && _knownVersions.Contains(projectVersion);
       }
 
-      public static ProjectVersion FindBy(int version)
+      public static bool ProjectIsTooOld(int projectVersion)
       {
-         return _knownVersions[version];
+         return projectVersion <= UNSUPPORTED;
       }
+
+      public static ProjectVersion FindBy(int version) => _knownVersions[version];
    }
 }
\ No newline at end of file
diff --git a/src/MoBi.Core/Properties/AssemblyInfo.cs b/src/MoBi.Core/Properties/AssemblyInfo.cs
deleted file mode 100644
index eec116d75..000000000
--- a/src/MoBi.Core/Properties/AssemblyInfo.cs
+++ /dev/null
@@ -1,8 +0,0 @@
-using System.Reflection;
-
-// General Information about an assembly is controlled through the following 
-// set of attributes. Change these attribute values to modify the information
-// associated with an assembly.
-
-[assembly: AssemblyTitle("MoBiCore")]
-[assembly: AssemblyDescription("")]
diff --git a/src/MoBi.Core/Serialization/Converter/v3_1/Converter30To313.cs b/src/MoBi.Core/Serialization/Converter/v3_1/Converter30To313.cs
deleted file mode 100644
index 0bfdeb70d..000000000
--- a/src/MoBi.Core/Serialization/Converter/v3_1/Converter30To313.cs
+++ /dev/null
@@ -1,82 +0,0 @@
-using System.Xml.Linq;
-using OSPSuite.Utility.Extensions;
-using MoBi.Core.Domain.Model;
-using OSPSuite.Core.Domain;
-using OSPSuite.Core.Domain.Builder;
-using OSPSuite.Core.Domain.Formulas;
-
-namespace MoBi.Core.Serialization.Converter.v3_1
-{
-   public class Converter30To313 : IMoBiObjectConverter
-   {
-      private readonly IParameterStartValuesUpdater _parameterStartValuesUpdater;
-      private readonly ISpatialStructureUpdaterTo3_1_3 _spatialStructureUpdater;
-      private readonly IModelUpdaterTo3_1_3 _modelUpdater;
-
-      public Converter30To313(IParameterStartValuesUpdater parameterStartValuesUpdater, ISpatialStructureUpdaterTo3_1_3 spatialStructureUpdater, IModelUpdaterTo3_1_3 modelUpdater)
-      {
-         _parameterStartValuesUpdater = parameterStartValuesUpdater;
-         _spatialStructureUpdater = spatialStructureUpdater;
-         _modelUpdater = modelUpdater;
-      }
-
-      private void updateSimulationTo313(IMoBiSimulation sim)
-      {
-         _modelUpdater.UpdateModel(sim.Model);
-         _spatialStructureUpdater.UpdateSpatialStructre((IMoBiSpatialStructure) sim.MoBiBuildConfiguration.SpatialStructure);
-         _parameterStartValuesUpdater.UpdateParameterStartvalues(sim.MoBiBuildConfiguration.ParameterStartValues, sim);
-         sim.HasChanged = true;
-      }
-
-      public (int convertedToVersion, bool conversionHappened) Convert(object objectToUpdate, IMoBiProject project)
-      {
-         if (objectToUpdate.IsAnImplementationOf<IParameterStartValuesBuildingBlock>())
-         {
-            _parameterStartValuesUpdater.UpdateParameterStartvalues((IParameterStartValuesBuildingBlock) objectToUpdate, project);
-         }
-         else if (objectToUpdate.IsAnImplementationOf<IParameterStartValue>())
-         {
-            _parameterStartValuesUpdater.UpdateParameterStartValue((IParameterStartValue) objectToUpdate, project);
-         }
-         else if (objectToUpdate.IsAnImplementationOf<IMoBiSimulation>())
-         {
-            updateSimulationTo313((IMoBiSimulation) objectToUpdate);
-         }
-         else if (objectToUpdate.IsAnImplementationOf<IMoBiSpatialStructure>())
-         {
-            _spatialStructureUpdater.UpdateSpatialStructre((IMoBiSpatialStructure) objectToUpdate);
-         }
-         else if (objectToUpdate.IsAnImplementationOf<IContainer>())
-         {
-            _spatialStructureUpdater.UpdateContainerTo3_1_3((IContainer) objectToUpdate);
-         }
-         else if (objectToUpdate.IsAnImplementationOf<IMoBiBuildConfiguration>())
-         {
-            var buidlConfiguratuion = (IMoBiBuildConfiguration) objectToUpdate;
-            _spatialStructureUpdater.UpdateSpatialStructre((IMoBiSpatialStructure) buidlConfiguratuion.SpatialStructure);
-            _parameterStartValuesUpdater.UpdateParameterStartvalues(buidlConfiguratuion.ParameterStartValues, project);
-         }
-         else if (objectToUpdate.IsAnImplementationOf<IDistributedParameter>())
-         {
-            var distributedParameter = (IDistributedParameter) objectToUpdate;
-            if (distributedParameter.Formula.IsAnImplementationOf<LogNormalDistributionFormula>())
-            {
-               _spatialStructureUpdater.UpdateDistributedParameterTo3_1_3(distributedParameter);
-            }
-         }
-
-         //Almost every single object is being converted here. Returns true for compatibility reasons
-         return (ProjectVersions.V3_1_3, true);
-      }
-
-      public (int convertedToVersion, bool conversionHappened) ConvertXml(XElement element, IMoBiProject project)
-      {
-         return (ProjectVersions.V3_1_3, false);
-      }
-
-      public  bool IsSatisfiedBy(int version)
-      {
-         return version == ProjectVersions.V3_0_1_to_3;
-      }
-   }
-}
\ No newline at end of file
diff --git a/src/MoBi.Core/Serialization/Converter/v3_1/DimensionRetriever.cs b/src/MoBi.Core/Serialization/Converter/v3_1/DimensionRetriever.cs
deleted file mode 100644
index f2f0cd500..000000000
--- a/src/MoBi.Core/Serialization/Converter/v3_1/DimensionRetriever.cs
+++ /dev/null
@@ -1,141 +0,0 @@
-using System.Linq;
-using MoBi.Core.Domain.Model;
-using SBSuite.Core.Domain;
-using SBSuite.Core.Domain.Builder;
-using SBSuite.Core.Domain.UnitSystem;
-
-namespace MoBi.Core.Serialization.Converter.v3_1
-{
-   public interface IDimensionRetriever
-   {
-      IDimension GetDimensionFor(IParameterStartValue psv, IParameterStartValuesBuildingBlock parameterStartValuesBuildingBlock, IMoBiProject project);
-      IDimension GetDimensionFor(IParameterStartValue psv, IParameterStartValuesBuildingBlock parameterStartValuesBuildingBlock, IMoBiSimulation simulation);
-   }
-
-   internal class DimensionRetriever : IDimensionRetriever
-   {
-      public IDimension GetDimensionFor(IParameterStartValue psv, IParameterStartValuesBuildingBlock parameterStartValuesBuildingBlock, IMoBiSimulation simulation)
-      {
-         var parameter = psv.Path.Resolve<IParameter>(simulation.Model.Root);
-         return parameter == null ? null : parameter.Dimension;
-      }
-
-      public IDimension GetDimensionFor(IParameterStartValue psv, IParameterStartValuesBuildingBlock parameterStartValuesBuildingBlock, IMoBiProject project)
-      {
-         if (project == null) return null;
-
-         var parameter =
-            searchParameterInSimulations(psv, parameterStartValuesBuildingBlock,project) ??
-            searchParamterInSpatialStructures(psv, parameterStartValuesBuildingBlock, project) ??
-            searchParameterInMolecules(psv, parameterStartValuesBuildingBlock, project);
-
-         return parameter == null ? null : parameter.Dimension;
-      }
-
-      private IParameter searchParameterInMolecules(IParameterStartValue psv, IParameterStartValuesBuildingBlock parent, IMoBiProject project)
-      {
-         var parameterName = psv.Path.Last();
-         var tmpPath = psv.Path.Clone<IObjectPath>();
-         tmpPath.Remove(tmpPath.Last());
-         var moleculeName = tmpPath.Last();
-
-         var parameter = searchParameterInMoleculeBuildingBlock(project.MoleculeBlockCollection.FirstOrDefault(mb => mb.Id.Equals(parent.MoleculeBuildingBlockId)), moleculeName, parameterName);
-
-         foreach (var moleculeBuildingBlock in project.MoleculeBlockCollection)
-         {
-            parameter = searchParameterInMoleculeBuildingBlock(moleculeBuildingBlock, moleculeName, parameterName);
-            if (parameter != null) break;
-         }
-         return parameter;
-      }
-
-      private static IParameter searchParameterInMoleculeBuildingBlock(IMoleculeBuildingBlock moleculeBuildingBlock,
-                                                                       string moleculeName, string parameterName)
-      {
-         IParameter parameter = null;
-         if (moleculeBuildingBlock != null)
-         {
-            var moleculeBuilder = moleculeBuildingBlock[moleculeName];
-            if (moleculeBuilder != null)
-            {
-               parameter = moleculeBuilder
-                  .GetChildren<IParameter>(p => !p.BuildMode.Equals(ParameterBuildMode.Property))
-                  .FirstOrDefault(p => p.Name.Equals(parameterName));
-            }
-         }
-         return parameter;
-      }
-
-      private IParameter searchParamterInSpatialStructures(IParameterStartValue psv, IParameterStartValuesBuildingBlock parent, IMoBiProject project)
-      {
-         var parameterPath = psv.Path;
-         IParameter parameter = searchParamterInSpatialStructures(parameterPath, parent,project);
-         if (parameter == null)
-         {
-            parameterPath = psv.Path.Clone<IObjectPath>();
-            var parameterName = parameterPath.Last();
-            parameterPath.Remove(parameterName);
-            var tmp = parameterPath.Last();
-            parameterPath.Remove(tmp);
-            parameterPath.Add(Constants.MOLECULE_PROPERTIES);
-            parameterPath.Add(parameterName);
-            parameter = searchParamterInSpatialStructures(parameterPath, parent,project);
-         }
-         return parameter;
-      }
-
-      private IParameter searchParamterInSpatialStructures(IObjectPath parameterPath, IParameterStartValuesBuildingBlock parent, IMoBiProject project)
-      {
-         IParameter parameter = searchParameterInContainers(parameterPath, project.SpatialStructureCollection.FirstOrDefault(ss => ss.Id.Equals(parent.SpatialStructureId)));
-
-         if (parameter == null)
-         {
-            foreach (var spatialStructure in project.SpatialStructureCollection)
-            {
-               parameter = searchParameterInContainers(parameterPath, spatialStructure);
-               if (parameter != null) break;
-            }
-         }
-         return parameter;
-      }
-
-      private static IParameter searchParameterInContainers(IObjectPath parameterPath, IMoBiSpatialStructure spatialStructure)
-      {
-         if (spatialStructure == null) return null;
-         IParameter parameter = null;
-         foreach (var top in spatialStructure.TopContainers)
-         {
-            parameter = parameterPath.Resolve<IParameter>(top);
-            if (parameter != null) break;
-         }
-         if (parameter == null)
-         {
-            parameter = parameterPath.Resolve<IParameter>(spatialStructure.NeighborhoodsContainer);
-         }
-         return parameter;
-      }
-
-      private IParameter searchParameterInSimulations(IParameterStartValue psv, IParameterStartValuesBuildingBlock parent, IMoBiProject project)
-      {
-         IParameter parameter = null;
-         var simulations = project.Simulations.Where(sim => usesParameterStartValuesBB(sim, parent));
-         foreach (var simulation in simulations)
-         {
-            parameter = psv.Path.Resolve<IParameter>(simulation.Model.Root);
-            if (parameter != null) break;
-         }
-         return parameter;
-      }
-
-      private bool usesParameterStartValuesBB(IMoBiSimulation moBiSimulation, IParameterStartValuesBuildingBlock parameterStartValueBuildingBlock)
-      {
-         var templateBuildingBlock = moBiSimulation.MoBiBuildConfiguration.ParameterStartValuesInfo.TemplateBuildingBlock;
-
-         if (Equals(templateBuildingBlock,parameterStartValueBuildingBlock))
-            return true;
-
-         var parameterStartValuesBuildingBlock = moBiSimulation.MoBiBuildConfiguration.ParameterStartValues;
-         return parameterStartValuesBuildingBlock.Equals(parameterStartValueBuildingBlock) || parameterStartValuesBuildingBlock.Name.Equals(parameterStartValueBuildingBlock.Name);
-      }
-   }
-}
\ No newline at end of file
diff --git a/src/MoBi.Core/Serialization/Converter/v3_1/ModelUpdater.cs b/src/MoBi.Core/Serialization/Converter/v3_1/ModelUpdater.cs
deleted file mode 100644
index df21ad127..000000000
--- a/src/MoBi.Core/Serialization/Converter/v3_1/ModelUpdater.cs
+++ /dev/null
@@ -1,28 +0,0 @@
-using System;
-using OSPSuite.Utility.Extensions;
-using OSPSuite.Core.Domain;
-using OSPSuite.Core.Domain.Formulas;
-
-namespace MoBi.Core.Serialization.Converter.v3_1
-{
-   public interface IModelUpdaterTo3_1_3
-   {
-      void UpdateModel(IModel model);
-   }
-
-   internal class ModelUpdaterTo3_1_3 : IModelUpdaterTo3_1_3
-   {
-      public void UpdateModel(IModel model)
-      {
-         var distributedParamtersToChange = model.Root.GetAllChildren<IDistributedParameter>(dp => dp.Formula.IsAnImplementationOf<LogNormalDistributionFormula>());
-         distributedParamtersToChange.Each(UpdateDistributedParameterTo3_1_3);
-      }
-
-      public void UpdateDistributedParameterTo3_1_3(IDistributedParameter distributedParameter)
-      {
-         var geoSDParameter = distributedParameter.GetSingleChildByName<IParameter>(Constants.Distribution.GEOMETRIC_DEVIATION);
-         var constantFormula = ((ConstantFormula) geoSDParameter.Formula);
-         constantFormula.Value = Math.Exp(constantFormula.Value);
-      }
-   }
-}
\ No newline at end of file
diff --git a/src/MoBi.Core/Serialization/Converter/v3_1/ParameterStartValueDimensionRetriever.cs b/src/MoBi.Core/Serialization/Converter/v3_1/ParameterStartValueDimensionRetriever.cs
deleted file mode 100644
index dfc04b9f9..000000000
--- a/src/MoBi.Core/Serialization/Converter/v3_1/ParameterStartValueDimensionRetriever.cs
+++ /dev/null
@@ -1,141 +0,0 @@
-using System.Linq;
-using MoBi.Core.Domain.Model;
-using OSPSuite.Core.Domain;
-using OSPSuite.Core.Domain.Builder;
-using OSPSuite.Core.Domain.UnitSystem;
-
-namespace MoBi.Core.Serialization.Converter.v3_1
-{
-   public interface IParameterStartValueDimensionRetriever
-   {
-      IDimension GetDimensionFor(IParameterStartValue psv, IParameterStartValuesBuildingBlock parameterStartValuesBuildingBlock, IMoBiProject project);
-      IDimension GetDimensionFor(IParameterStartValue psv, IParameterStartValuesBuildingBlock parameterStartValuesBuildingBlock, IMoBiSimulation simulation);
-   }
-
-   internal class ParameterStartValueDimensionRetriever : IParameterStartValueDimensionRetriever
-   {
-      public IDimension GetDimensionFor(IParameterStartValue psv, IParameterStartValuesBuildingBlock parameterStartValuesBuildingBlock, IMoBiSimulation simulation)
-      {
-         var parameter = psv.Path.TryResolve<IParameter>(simulation.Model.Root);
-         return parameter == null ? null : parameter.Dimension;
-      }
-
-      public IDimension GetDimensionFor(IParameterStartValue psv, IParameterStartValuesBuildingBlock parameterStartValuesBuildingBlock, IMoBiProject project)
-      {
-         if (project == null) return null;
-
-         var parameter =
-            searchParameterInSimulations(psv, parameterStartValuesBuildingBlock,project) ??
-            searchParamterInSpatialStructures(psv, parameterStartValuesBuildingBlock, project) ??
-            searchParameterInMolecules(psv, parameterStartValuesBuildingBlock, project);
-
-         return parameter == null ? null : parameter.Dimension;
-      }
-
-      private IParameter searchParameterInMolecules(IParameterStartValue psv, IParameterStartValuesBuildingBlock parent, IMoBiProject project)
-      {
-         var parameterName = psv.Path.Last();
-         var tmpPath = psv.Path.Clone<IObjectPath>();
-         tmpPath.Remove(tmpPath.Last());
-         var moleculeName = tmpPath.Last();
-
-         var parameter = searchParameterInMoleculeBuildingBlock(project.MoleculeBlockCollection.FirstOrDefault(mb => mb.Id.Equals(parent.MoleculeBuildingBlockId)), moleculeName, parameterName);
-
-         foreach (var moleculeBuildingBlock in project.MoleculeBlockCollection)
-         {
-            parameter = searchParameterInMoleculeBuildingBlock(moleculeBuildingBlock, moleculeName, parameterName);
-            if (parameter != null) break;
-         }
-         return parameter;
-      }
-
-      private static IParameter searchParameterInMoleculeBuildingBlock(IMoleculeBuildingBlock moleculeBuildingBlock,
-                                                                       string moleculeName, string parameterName)
-      {
-         IParameter parameter = null;
-         if (moleculeBuildingBlock != null)
-         {
-            var moleculeBuilder = moleculeBuildingBlock[moleculeName];
-            if (moleculeBuilder != null)
-            {
-               parameter = moleculeBuilder
-                  .GetChildren<IParameter>(p => !p.BuildMode.Equals(ParameterBuildMode.Property))
-                  .FirstOrDefault(p => p.Name.Equals(parameterName));
-            }
-         }
-         return parameter;
-      }
-
-      private IParameter searchParamterInSpatialStructures(IParameterStartValue psv, IParameterStartValuesBuildingBlock parent, IMoBiProject project)
-      {
-         var parameterPath = psv.Path;
-         IParameter parameter = searchParamterInSpatialStructures(parameterPath, parent,project);
-         if (parameter == null)
-         {
-            parameterPath = psv.Path.Clone<IObjectPath>();
-            var parameterName = parameterPath.Last();
-            parameterPath.Remove(parameterName);
-            var tmp = parameterPath.Last();
-            parameterPath.Remove(tmp);
-            parameterPath.Add(Constants.MOLECULE_PROPERTIES);
-            parameterPath.Add(parameterName);
-            parameter = searchParamterInSpatialStructures(parameterPath, parent,project);
-         }
-         return parameter;
-      }
-
-      private IParameter searchParamterInSpatialStructures(IObjectPath parameterPath, IParameterStartValuesBuildingBlock parent, IMoBiProject project)
-      {
-         IParameter parameter = searchParameterInContainers(parameterPath, project.SpatialStructureCollection.FirstOrDefault(ss => ss.Id.Equals(parent.SpatialStructureId)));
-
-         if (parameter == null)
-         {
-            foreach (var spatialStructure in project.SpatialStructureCollection)
-            {
-               parameter = searchParameterInContainers(parameterPath, spatialStructure);
-               if (parameter != null) break;
-            }
-         }
-         return parameter;
-      }
-
-      private static IParameter searchParameterInContainers(IObjectPath parameterPath, IMoBiSpatialStructure spatialStructure)
-      {
-         if (spatialStructure == null) return null;
-         IParameter parameter = null;
-         foreach (var top in spatialStructure.TopContainers)
-         {
-            parameter = parameterPath.TryResolve<IParameter>(top);
-            if (parameter != null) break;
-         }
-         if (parameter == null)
-         {
-            parameter = parameterPath.TryResolve<IParameter>(spatialStructure.NeighborhoodsContainer);
-         }
-         return parameter;
-      }
-
-      private IParameter searchParameterInSimulations(IParameterStartValue psv, IParameterStartValuesBuildingBlock parent, IMoBiProject project)
-      {
-         IParameter parameter = null;
-         var simulations = project.Simulations.Where(sim => usesParameterStartValuesBB(sim, parent));
-         foreach (var simulation in simulations)
-         {
-            parameter = psv.Path.TryResolve<IParameter>(simulation.Model.Root);
-            if (parameter != null) break;
-         }
-         return parameter;
-      }
-
-      private bool usesParameterStartValuesBB(IMoBiSimulation moBiSimulation, IParameterStartValuesBuildingBlock parameterStartValueBuildingBlock)
-      {
-         var templateBuildingBlock = moBiSimulation.MoBiBuildConfiguration.ParameterStartValuesInfo.TemplateBuildingBlock;
-
-         if (Equals(templateBuildingBlock,parameterStartValueBuildingBlock))
-            return true;
-
-         var parameterStartValuesBuildingBlock = moBiSimulation.MoBiBuildConfiguration.ParameterStartValues;
-         return parameterStartValuesBuildingBlock.Equals(parameterStartValueBuildingBlock) || parameterStartValuesBuildingBlock.Name.Equals(parameterStartValueBuildingBlock.Name);
-      }
-   }
-}
\ No newline at end of file
diff --git a/src/MoBi.Core/Serialization/Converter/v3_1/ParameterStartValuesUpdater.cs b/src/MoBi.Core/Serialization/Converter/v3_1/ParameterStartValuesUpdater.cs
deleted file mode 100644
index 9fd0367e8..000000000
--- a/src/MoBi.Core/Serialization/Converter/v3_1/ParameterStartValuesUpdater.cs
+++ /dev/null
@@ -1,88 +0,0 @@
-using System;
-using MoBi.Assets;
-using MoBi.Core.Domain.Model;
-using OSPSuite.Core.Domain;
-using OSPSuite.Core.Domain.Builder;
-using OSPSuite.Core.Domain.UnitSystem;
-using OSPSuite.Utility.Extensions;
-
-namespace MoBi.Core.Serialization.Converter.v3_1
-{
-   public interface IParameterStartValuesUpdater
-   {
-      void UpdateParameterStartvalues(IParameterStartValuesBuildingBlock parameterStartValuesBuildingBlock, IMoBiProject project);
-      void UpdateParameterStartValue(IParameterStartValue parameterStartValue, IMoBiProject project);
-      void UpdateParameterStartvalues(IParameterStartValuesBuildingBlock parameterStartValuesBuildingBlock, IMoBiSimulation simulation);
-   }
-
-   internal class ParameterStartValuesUpdater : IParameterStartValuesUpdater
-   {
-      private readonly IParameterStartValueDimensionRetriever _dimensionRetriever;
-      private IParameterStartValuesBuildingBlock _parameterStartValuesBuildingBlock;
-      private readonly IDimensionFactory _dimensionFactory;
-      private readonly IProjectConverterLogger _projectConverterLogger;
-
-      public ParameterStartValuesUpdater(IParameterStartValueDimensionRetriever dimensionRetriever, IDimensionFactory dimensionFactory, IProjectConverterLogger projectConverterLogger)
-      {
-         _dimensionRetriever = dimensionRetriever;
-         _dimensionFactory = dimensionFactory;
-         _projectConverterLogger = projectConverterLogger;
-      }
-
-      public void UpdateParameterStartvalues(IParameterStartValuesBuildingBlock parameterStartValuesBuildingBlock, IMoBiProject project)
-      {
-         _parameterStartValuesBuildingBlock = parameterStartValuesBuildingBlock;
-         _projectConverterLogger.AddInfo(AppConstants.ProjectUpdateMessages.UpdatePSV(parameterStartValuesBuildingBlock.Name), parameterStartValuesBuildingBlock, parameterStartValuesBuildingBlock);
-         parameterStartValuesBuildingBlock.Each(psv => UpdateParameterStartValue(psv, project));
-      }
-
-      public void UpdateParameterStartvalues(IParameterStartValuesBuildingBlock parameterStartValuesBuildingBlock, IMoBiSimulation simulation)
-      {
-         _parameterStartValuesBuildingBlock = parameterStartValuesBuildingBlock;
-         _projectConverterLogger.AddInfo(AppConstants.ProjectUpdateMessages.UpdatePSV(parameterStartValuesBuildingBlock.Name), parameterStartValuesBuildingBlock, parameterStartValuesBuildingBlock);
-         parameterStartValuesBuildingBlock.Each(psv => UpdateParameterStartValue(psv, simulation));
-      }
-
-      public void UpdateParameterStartValue(IParameterStartValue parameterStartValue, IMoBiProject project)
-      {
-         updateDimension(parameterStartValue, project);
-         var parameterName = parameterStartValue.ParameterName;
-         if (parameterName.Equals(Constants.Distribution.GEOMETRIC_DEVIATION))
-         {
-            parameterStartValue.StartValue = Math.Exp(parameterStartValue.StartValue.Value);
-         }
-      }
-
-      public void UpdateParameterStartValue(IParameterStartValue parameterStartValue, IMoBiSimulation simulation)
-      {
-         updateDimension(parameterStartValue, simulation);
-         var parameterName = parameterStartValue.ParameterName;
-         if (parameterName.Equals(Constants.Distribution.GEOMETRIC_DEVIATION))
-         {
-            parameterStartValue.StartValue = Math.Exp(parameterStartValue.StartValue.Value);
-         }
-      }
-
-      private void updateDimension(IParameterStartValue psv, IMoBiProject project)
-      {
-         var dimension = _dimensionRetriever.GetDimensionFor(psv, _parameterStartValuesBuildingBlock, project);
-         if (dimension == null)
-         {
-            dimension = _dimensionFactory.NoDimension;
-            _projectConverterLogger.AddSubMessage(AppConstants.ProjectUpdateMessages.UnableToGetDimensionFor(psv, _parameterStartValuesBuildingBlock.Name), _parameterStartValuesBuildingBlock);
-         }
-         psv.Dimension = dimension;
-      }
-
-      private void updateDimension(IParameterStartValue psv, IMoBiSimulation simulation)
-      {
-         var dimension = _dimensionRetriever.GetDimensionFor(psv, _parameterStartValuesBuildingBlock, simulation);
-         if (dimension == null)
-         {
-            dimension = _dimensionFactory.NoDimension;
-            _projectConverterLogger.AddSubMessage(AppConstants.ProjectUpdateMessages.UnableToGetDimensionFor(psv, _parameterStartValuesBuildingBlock.Name), _parameterStartValuesBuildingBlock);
-         }
-         psv.Dimension = dimension;
-      }
-   }
-}
diff --git a/src/MoBi.Core/Serialization/Converter/v3_1/SpatialStructureUpdater.cs b/src/MoBi.Core/Serialization/Converter/v3_1/SpatialStructureUpdater.cs
deleted file mode 100644
index 536263da0..000000000
--- a/src/MoBi.Core/Serialization/Converter/v3_1/SpatialStructureUpdater.cs
+++ /dev/null
@@ -1,40 +0,0 @@
-using System;
-using OSPSuite.Utility.Extensions;
-using MoBi.Core.Domain.Model;
-using OSPSuite.Core.Domain;
-using OSPSuite.Core.Domain.Formulas;
-
-namespace MoBi.Core.Serialization.Converter.v3_1
-{
-   public interface ISpatialStructureUpdaterTo3_1_3
-   {
-      void UpdateSpatialStructre(IMoBiSpatialStructure spatialStructure);
-      void UpdateDistributedParameterTo3_1_3(IDistributedParameter distributedParameter);
-      void UpdateContainerTo3_1_3(IContainer container);
-   }
-
-   internal class SpatialStructureUpdaterTo3_1_3 : ISpatialStructureUpdaterTo3_1_3
-   {
-      public void UpdateSpatialStructre(IMoBiSpatialStructure spatialStructure)
-      {
-         foreach (var topContainer in spatialStructure.TopContainers)
-         {
-            UpdateContainerTo3_1_3(topContainer);
-         }
-      }
-
-      public void UpdateContainerTo3_1_3(IContainer container)
-      {
-         container.GetAllChildren<IDistributedParameter>(
-            dp => dp.Formula.IsAnImplementationOf<LogNormalDistributionFormula>())
-            .Each(UpdateDistributedParameterTo3_1_3);
-      }
-
-      public void UpdateDistributedParameterTo3_1_3(IDistributedParameter distributedParameter)
-      {
-         var geoSDParameter = distributedParameter.GetSingleChildByName<IParameter>(Constants.Distribution.GEOMETRIC_DEVIATION);
-         var constantFormula = ((ConstantFormula) geoSDParameter.Formula);
-         constantFormula.Value = Math.Exp(constantFormula.Value);
-      }
-   }
-}
\ No newline at end of file
diff --git a/src/MoBi.Core/Serialization/Converter/v3_2/Converter313To32.cs b/src/MoBi.Core/Serialization/Converter/v3_2/Converter313To32.cs
deleted file mode 100644
index 1a2b47b3e..000000000
--- a/src/MoBi.Core/Serialization/Converter/v3_2/Converter313To32.cs
+++ /dev/null
@@ -1,578 +0,0 @@
-using System;
-using System.Collections.Generic;
-using System.Linq;
-using System.Xml.Linq;
-using MoBi.Assets;
-using MoBi.Core.Domain.Model;
-using MoBi.Core.Domain.UnitSystem;
-using MoBi.Core.Events;
-using MoBi.Core.Helper;
-using OSPSuite.Core.Converter.v5_2;
-using OSPSuite.Core.Domain;
-using OSPSuite.Core.Domain.Builder;
-using OSPSuite.Core.Domain.Data;
-using OSPSuite.Core.Domain.Formulas;
-using OSPSuite.Core.Domain.UnitSystem;
-using OSPSuite.Core.Serialization.Exchange;
-using OSPSuite.Assets;
-using OSPSuite.Serializer.Xml.Extensions;
-using OSPSuite.Utility.Events;
-using OSPSuite.Utility.Extensions;
-using OSPSuite.Utility.Visitor;
-
-namespace MoBi.Core.Serialization.Converter.v3_2
-{
-   public class Converter313To32 : IMoBiObjectConverter,
-                                   IVisitor<DataRepository>,
-                                   IVisitor<ISpatialStructure>,
-                                   IVisitor<IMoleculeBuildingBlock>,
-                                   IVisitor<IParameterStartValuesBuildingBlock>,
-                                   IVisitor<IMoleculeStartValuesBuildingBlock>,
-                                   IVisitor<IPassiveTransportBuildingBlock>,
-                                   IVisitor<IObserverBuildingBlock>,
-                                   IVisitor<IReactionBuildingBlock>,
-                                   IVisitor<IEventGroupBuildingBlock>,
-                                   IVisitor<IMoBiSimulation>,
-                                   IVisitor<SimulationTransfer>,
-                                   IVisitor<IMoBiProject>
-   {
-      private readonly IDimensionConverter _dimensionConverter;
-      private readonly IMoBiDimensionFactory _dimensionFactory;
-      private readonly IObjectBaseFactory _objectBaseFactory;
-      private readonly IFormulaMapper _formulaMapper;
-      private readonly IDimensionMapper _dimensionMapper;
-      private readonly IEventPublisher _eventPublisher;
-      private readonly ObjectTypeResolver _objectTypeResolver;
-      private bool _suspendWarning;
-      private bool _converted;
-
-      public Converter313To32(IDimensionConverter dimensionConverter, IMoBiDimensionFactory dimensionFactory,
-                              IObjectBaseFactory objectBaseFactory, IFormulaMapper formulaMapper, IDimensionMapper dimensionMapper, IEventPublisher eventPublisher)
-      {
-         _dimensionConverter = dimensionConverter;
-         _dimensionFactory = dimensionFactory;
-         _objectBaseFactory = objectBaseFactory;
-         _formulaMapper = formulaMapper;
-         _dimensionMapper = dimensionMapper;
-         _eventPublisher = eventPublisher;
-         _objectTypeResolver = new ObjectTypeResolver();
-         _suspendWarning = false;
-      }
-
-      public bool IsSatisfiedBy(int version)
-      {
-         return version == ProjectVersions.V3_1_3;
-      }
-
-      public (int convertedToVersion, bool conversionHappened) Convert(object objectToConvert, IMoBiProject project)
-      {
-         _converted = false;
-         this.Visit(objectToConvert);
-         return (ProjectVersions.V3_2_1, _converted);
-      }
-
-      public (int convertedToVersion, bool conversionHappened) ConvertXml(XElement element, IMoBiProject project)
-      {
-         _dimensionConverter.ConvertDimensionIn(element);
-         convertOutputSchemaForSimulations(element);
-         convertParameterContainerToContainer(element);
-         convertActiveTransportContainersToChildren(element);
-         convertPassiveTransportsToChildren(element);
-         convertApplicationTransportsToChildren(element);
-         convertDimensionFactory(element);
-         convetSimulation(element);
-         convertObservers(element);
-         
-         return (ProjectVersions.V3_2_1, true);
-      }
-
-      private void convertPassiveTransportsToChildren(XElement element)
-      {
-         var passiveTransports = element.Descendants("AllPassiveTransports");
-         foreach (var passiveTransportsElement in passiveTransports)
-         {
-            var childList = getOrRetrieveChidrensElementFrom(passiveTransportsElement.Parent);
-            childList.Add(passiveTransportsElement.Elements("TransportBuilder"));
-         }
-      }
-
-      private void convertObservers(XElement element)
-      {
-         foreach (var observerBuildingBlock in descendantsAndSelfNamed(element, AppConstants.XmlNames.ObserverBuildingBlock, AppConstants.XmlNames.Observers))
-         {
-            var builders = observerBuildingBlock.Element("Builders");
-            if (builders == null)
-               continue;
-
-            foreach (var observerNode in builders.Elements())
-            {
-               var moleculeList = new XElement(AppConstants.XmlNames.MoleculeList, observerNode.Attribute("forAll"));
-               var moleculeNamesNodes = observerNode.Descendants("MoleculeNames");
-               foreach (var moleculeName in moleculeNamesNodes)
-               {
-                  moleculeList.Add(moleculeName);
-               }
-               observerNode.Add(moleculeList);
-            }
-         }
-      }
-
-      private static IEnumerable<XElement> descendantsAndSelfNamed(XElement element, params string[] names)
-      {
-         return element.DescendantsAndSelf().Where(x => names.Contains(x.Name.ToString()));
-      }
-      private void convetSimulation(XElement element)
-      {
-         foreach (var settings in element.Descendants(AppConstants.XmlNames.CVODESettings))
-         {
-            var newNode = new XElement(AppConstants.XmlNames.Solver, settings.Attributes(), settings.Nodes());
-            settings.Parent.Add(newNode);
-         }
-      }
-
-      private void convertDimensionFactory(XElement element)
-      {
-         foreach (var dimensionElement in element.DescendantsAndSelf("DimensionFactory").SelectMany(x => x.Descendants("Dimension")))
-         {
-            var oldBaseUnit = dimensionElement.Attribute("BaseUnit");
-            if (oldBaseUnit == null) continue;
-
-            dimensionElement.AddAttribute("baseUnit", oldBaseUnit.Value);
-
-            var oldDefaultUnit = dimensionElement.Attribute("DefaultUnit");
-            if (oldDefaultUnit == null) continue;
-
-            dimensionElement.AddAttribute("defaultUnit", oldDefaultUnit.Value);
-         }
-      }
-
-      private void convertApplicationTransportsToChildren(XElement element)
-      {
-         var transports = element.Descendants("Transports");
-         foreach (var transport in transports)
-         {
-            var childrenList = getOrRetrieveChidrensElementFrom(transport.Parent);
-            childrenList.Add(transport.Elements("TransportBuilder"));
-         }
-         var applicationMolecuBuilderList = element.Descendants("MoleculeNames");
-         foreach (var moleculeBuilder in applicationMolecuBuilderList)
-         {
-            var childrenList = getOrRetrieveChidrensElementFrom(moleculeBuilder.Parent);
-            childrenList.Add(moleculeBuilder.Elements("ApplicationMoleculeBuilder"));
-         }
-      }
-
-      private void convertActiveTransportContainersToChildren(XElement element)
-      {
-         var activeTransoporterList = element.Descendants("ActiveTransportRealizations");
-         foreach (var transportList in activeTransoporterList)
-         {
-            var childList = getOrRetrieveChidrensElementFrom(transportList.Parent);
-            childList.Add(transportList.Elements("TransportBuilder"));
-         }
-      }
-
-      private void convertParameterContainerToContainer(XElement element)
-      {
-         var parametersList = element.Descendants("Parameters");
-         foreach (var parametersElement in parametersList)
-         {
-            var childrenElement = getOrRetrieveChidrensElementFrom(parametersElement.Parent);
-            childrenElement.Add(parametersElement.Elements());
-         }
-      }
-
-      private XElement getOrRetrieveChidrensElementFrom(XElement parent)
-      {
-         var childrenElment = parent.Element("Children");
-         if (childrenElment == null)
-         {
-            childrenElment = parent.AddElement(new XElement("Children"));
-         }
-         return childrenElment;
-      }
-
-      private void convertOutputSchemaForSimulations(XElement element)
-      {
-         foreach (var outputSchemaElement in element.Descendants("OutputSchema"))
-         {
-            var intervals = outputSchemaElement.Descendants("OutputInterval");
-            outputSchemaElement.Add(newId());
-            outputSchemaElement.AddAttribute("name", Constants.OUTPUT_SCHEMA);
-            var outputSchemaChildren = new XElement("Children");
-
-            int i = 0;
-            foreach (var interval in intervals)
-            {
-               var outputIntervalElementChildren = new XElement("Children");
-               outputIntervalElementChildren.Add(parameterElement(Constants.Parameters.START_TIME, Constants.Dimension.TIME, interval.GetAttribute("startTime")));
-               outputIntervalElementChildren.Add(parameterElement(Constants.Parameters.END_TIME, Constants.Dimension.TIME, interval.GetAttribute("endTime")));
-               outputIntervalElementChildren.Add(parameterElement(Constants.Parameters.RESOLUTION, Constants.Dimension.RESOLUTION, interval.GetAttribute("resolution")));
-               outputSchemaChildren.Add(new XElement("OutputInterval", new XAttribute("name", string.Format("{0} {1}", Constants.OUTPUT_INTERVAL, i)), outputIntervalElementChildren));
-               i++;
-            }
-            outputSchemaElement.Add(outputSchemaChildren);
-         }
-      }
-
-      private XElement parameterElement(string name, string dimension, string value)
-      {
-         return new XElement("Parameter",
-                             newId(),
-                             new XAttribute("name", name),
-                             new XAttribute(Constants.Serialization.Attribute.Dimension, dimension),
-                             new XAttribute(Constants.Serialization.Attribute.VALUE, value)
-            );
-      }
-
-      private XAttribute newId()
-      {
-         return new XAttribute("id", Guid.NewGuid().ToString());
-      }
-
-      public void Visit(DataRepository dataRepository)
-      {
-         _dimensionConverter.ConvertDimensionIn(dataRepository);
-         _converted = true;
-      }
-
-      private void convert<T>(IBuildingBlock<T> buildingBlock) where T : class, IObjectBase
-      {
-         _dimensionConverter.ConvertDimensionIn(buildingBlock);
-         createDimensionWarningsForBuildingBlock(buildingBlock);
-      }
-
-      public void Visit(ISpatialStructure spatialStructure)
-      {
-         convert(spatialStructure);
-         spatialStructure.TopContainers.Each(convertSpecialParametersIn);
-         updateForPKSimChanges(spatialStructure);
-         _converted = true;
-      }
-
-      public void Visit(IMoleculeBuildingBlock moleculeBuildingBlock)
-      {
-         convert(moleculeBuildingBlock);
-         updateForPKSimChanges(moleculeBuildingBlock);
-         _converted = true;
-      }
-
-      private void updateForPKSimChanges(IMoleculeBuildingBlock moleculeBuildingBlock)
-      {
-         var calculatedSpecificIntestinalPermeabilityTranscellularFormula =
-            moleculeBuildingBlock.FormulaCache.FindByName("PARAM_P_int_InVitro");
-         if (calculatedSpecificIntestinalPermeabilityTranscellularFormula == null) return;
-         var velocity = _dimensionFactory.Dimension(AppConstants.DimensionNames.VELOCITY);
-         moleculeBuildingBlock.Each(mb=>addCalculatedSpecificIntestinalPermeabilityTranscellularParameterTo(mb,calculatedSpecificIntestinalPermeabilityTranscellularFormula,velocity));
-      }
-
-      private void addCalculatedSpecificIntestinalPermeabilityTranscellularParameterTo(IMoleculeBuilder moleculeBuilder, IFormula formula, IDimension dimension)
-      {
-         if (!isPKSimMolecule(moleculeBuilder)) return;
-         moleculeBuilder.Add(_objectBaseFactory
-            .Create<IParameter>()
-            .WithName("Calculated specific intestinal permeability (transcellular)")
-            .WithFormula(formula)
-            .WithDimension(dimension)
-            .WithMode(ParameterBuildMode.Global));
-      }
-
-      private bool isPKSimMolecule(IMoleculeBuilder moleculeBuilder)
-      {
-         return moleculeBuilder.ContainsName("Effective molecular weight");
-      }
-
-      private void updateForPKSimChanges(ISpatialStructure spatialStructure)
-      {
-         if (canAddNewParametersTo(spatialStructure))
-         {
-            var blood2PlasmaFormula = createBlood2PlasmaFormula();
-            var mucosaPermeabilityScaleFactorTranscellularFormula =createMucosaPermeabilityScaleFactor_transcellularFormula();
-            var defaultIntestinalPermeabilityTranscellularFormula =creteDefaultIntestinalPermeabilityTranscellularFormula();
-            spatialStructure.AddFormula(blood2PlasmaFormula);
-            spatialStructure.AddFormula(mucosaPermeabilityScaleFactorTranscellularFormula);
-            spatialStructure.AddFormula(defaultIntestinalPermeabilityTranscellularFormula);
-            spatialStructure.GlobalMoleculeDependentProperties.Add(createBlood2PlasmaRatioParameter(blood2PlasmaFormula));
-            spatialStructure.GlobalMoleculeDependentProperties.Add(createMucosaPermeabilityScaleFactorTranscellularParameter(mucosaPermeabilityScaleFactorTranscellularFormula));
-            spatialStructure.GlobalMoleculeDependentProperties.Add(createDefaultIntestinalPermeabilityTranscellularParameter(defaultIntestinalPermeabilityTranscellularFormula));
-         }
-         if (is2PoreModel(spatialStructure))
-         {
-            var moleculeProperties = spatialStructure.NeighborhoodsContainer.GetSingleChildByName<IContainer>("EndogenousIgG_int_EndogenousIgG_pls").GetSingleChildByName<IContainer>(Constants.MOLECULE_PROPERTIES);
-            if(moleculeProperties==null) return;
-            var partitionCoefficient =
-               moleculeProperties.GetSingleChildByName<IParameter>("Partition coefficient (interstitial/plasma)");
-            // Change Formula to Constant
-            if(partitionCoefficient==null) return;
-               partitionCoefficient.Formula = _objectBaseFactory.Create<ConstantFormula>().WithValue(1);
-         }
-      }
-
-      private bool is2PoreModel(ISpatialStructure spatialStructure)
-      {
-         return spatialStructure.NeighborhoodsContainer.ContainsName("EndogenousIgG_int_EndogenousIgG_pls");
-      }
-
-      private IParameter createDefaultIntestinalPermeabilityTranscellularParameter(IFormula formula)
-      {
-         return _objectBaseFactory.Create<IParameter>().WithName("Default Intestinal permeability (transcellular)")
-            .WithMode(ParameterBuildMode.Global)
-            .WithFormula(formula)
-            .WithDimension(_dimensionFactory.Dimension(AppConstants.DimensionNames.VELOCITY));
-      }
-
-      private IParameter createMucosaPermeabilityScaleFactorTranscellularParameter(IFormula mucosaPermeabilityScaleFactorTranscellularFormula)
-      {
-         return _objectBaseFactory.Create<IParameter>().WithName("Mucosa permeability scale factor (transcellular)")
-            .WithMode(ParameterBuildMode.Global)
-            .WithFormula(mucosaPermeabilityScaleFactorTranscellularFormula)
-            .WithDimension(Constants.Dimension.NO_DIMENSION);
-      }
-
-      private IFormula creteDefaultIntestinalPermeabilityTranscellularFormula()
-      {
-         var velocity = _dimensionFactory.Dimension(AppConstants.DimensionNames.VELOCITY);
-         IFormula defaultIntestinalPermeabilityTranscellularFormula = _objectBaseFactory
-            .Create<ExplicitFormula>()
-            .WithFormulaString("P_int_InVitro")
-            .WithDimension(velocity)
-            .WithName("PARAM_P_int_trans_default");
-         defaultIntestinalPermeabilityTranscellularFormula.AddObjectPath(
-            createFormulaUsablePath(new string[]{ ObjectPath.PARENT_CONTAINER,"Calculated specific intestinal permeability (transcellular)"},"P_int_InVitro",velocity)
-            );
-         return defaultIntestinalPermeabilityTranscellularFormula;
-      }
-
-      private IFormula createMucosaPermeabilityScaleFactor_transcellularFormula()
-      {
-         IFormula mucosaPermeabilityScaleFactor_transcellularFormula = _objectBaseFactory
-            .Create<ExplicitFormula>()
-            .WithFormulaString("P_int_trans_default >0 ? P_int_trans / P_int_trans_default : 0")
-            .WithDimension(Constants.Dimension.NO_DIMENSION)
-            .WithName("PARAM_P_int_scalefactor");
-         mucosaPermeabilityScaleFactor_transcellularFormula.AddObjectPath(
-            createFormulaUsablePath(new[] { ObjectPath.PARENT_CONTAINER, "Default Intestinal permeability (transcellular)" },"P_int_trans_default",_dimensionFactory.Dimension(AppConstants.DimensionNames.VELOCITY)));
-         mucosaPermeabilityScaleFactor_transcellularFormula.AddObjectPath(
-            createFormulaUsablePath(new[] { ObjectPath.PARENT_CONTAINER, "Intestinal permeability (transcellular)" }, "P_int_trans", _dimensionFactory.Dimension(AppConstants.DimensionNames.VELOCITY)));
-         return mucosaPermeabilityScaleFactor_transcellularFormula;
-      }
-
-      /// <summary>
-      ///    Creates the blood2 plasma formula.
-      /// </summary>
-      private IFormula createBlood2PlasmaFormula()
-      {
-         IFormula blood2PlasmaFormula = _objectBaseFactory
-            .Create<ExplicitFormula>()
-            .WithFormulaString(
-               "(f_water_rbc + f_lipids_rbc * 10 ^ LogP + f_proteins_rbc * KProt) * fu * HCT - HCT + 1")
-            .WithDimension(Constants.Dimension.NO_DIMENSION)
-            .WithName("PARAM_Blood2Plasma");
-         blood2PlasmaFormula.AddObjectPath(
-            createFormulaUsablePath(new[] {ObjectPathKeywords.MOLECULE, "Fraction unbound (plasma)"}, "fu", _dimensionFactory.Dimension(AppConstants.DimensionNames.FRACTION)));
-         blood2PlasmaFormula.AddObjectPath(
-            createFormulaUsablePath(new[] {ObjectPathKeywords.MOLECULE, "Lipophilicity"}, "LogP", _dimensionFactory.Dimension("Log Units")));
-         blood2PlasmaFormula.AddObjectPath(
-            createFormulaUsablePath(new[] {ObjectPathKeywords.MOLECULE, "Partition coefficient (water/protein)"}, "KProt", Constants.Dimension.NO_DIMENSION));
-         blood2PlasmaFormula.AddObjectPath(
-            createFormulaUsablePath(new[] {"Organism", "Hematocrit"}, "HCT", Constants.Dimension.NO_DIMENSION));
-         blood2PlasmaFormula.AddObjectPath(
-            createFormulaUsablePath(new[] {"Organism", "Vf (lipid, blood cells)"}, "f_lipids_rbc", Constants.Dimension.NO_DIMENSION));
-         blood2PlasmaFormula.AddObjectPath(
-            createFormulaUsablePath(new[] {"Organism", "Vf (protein,blood cells)"}, "f_proteins_rbc", Constants.Dimension.NO_DIMENSION));
-         blood2PlasmaFormula.AddObjectPath(
-            createFormulaUsablePath(new[] {"Organism", "Vf (water,blood cells)"}, "f_water_rbc", Constants.Dimension.NO_DIMENSION));
-         return blood2PlasmaFormula;
-      }
-
-      private FormulaUsablePath createFormulaUsablePath(string[] pathEntries, string paraAlias, IDimension dimension)
-      {
-         return new FormulaUsablePath(pathEntries)
-            .WithAlias(paraAlias)
-            .WithDimension(dimension);
-      }
-
-      private IParameter createBlood2PlasmaRatioParameter(IFormula blood2PlasmaFormula)
-      {
-         return _objectBaseFactory.Create<IParameter>().WithName("Blood/Plasma concentration ratio")
-            .WithMode(ParameterBuildMode.Property)
-            .WithFormula(blood2PlasmaFormula)
-            .WithDimension(Constants.Dimension.NO_DIMENSION);
-      }
-
-      private bool canAddNewParametersTo(ISpatialStructure spatialStructure)
-      {
-         //spatialStructure has needed parameters, so it is assumed it is original from PK-Sim
-         var organism = spatialStructure.TopContainers.FirstOrDefault(tc => tc.IsNamed("Organism"));
-         if (organism == null) return false;
-         return
-            organism.ContainsNames(new[] {"Hematocrit", "Vf (lipid, blood cells)", "Vf (protein,blood cells)", "Vf (water,blood cells)"});
-      }
-
-      public void Visit(IParameterStartValuesBuildingBlock parameterStartValuesBuildingBlock)
-      {
-         convert(parameterStartValuesBuildingBlock);
-         convertSpecialParametersIn(parameterStartValuesBuildingBlock);
-         _converted = true;
-      }
-
-      public void Visit(IMoleculeStartValuesBuildingBlock moleculeStartValuesBuildingBlock)
-      {
-         
-         moleculeStartValuesBuildingBlock.Each(msv=>msv.Dimension = _dimensionFactory.Dimension(Constants.Dimension.AMOUNT));
-         convert(moleculeStartValuesBuildingBlock);
-         _converted = true;
-      }
-
-      public void Visit(IPassiveTransportBuildingBlock passiveTransportBuildingBlock)
-      {
-         convert(passiveTransportBuildingBlock);
-         _converted = true;
-      }
-
-      public void Visit(IObserverBuildingBlock observerBuildingBlock)
-      {
-         convert(observerBuildingBlock);
-         _converted = true;
-      }
-
-      public void Visit(IReactionBuildingBlock reactionBuildingBlock)
-      {
-         convert(reactionBuildingBlock);
-         _converted = true;
-      }
-
-      public void Visit(IEventGroupBuildingBlock eventGroupBuildingBlock)
-      {
-         convert(eventGroupBuildingBlock);
-         var inversedVolume = _dimensionFactory.Dimension(AppConstants.DimensionNames.INVERSED_VOLUME);
-         eventGroupBuildingBlock.Each(eg => convertSpecialParameter(eg, "Number_Of_Particles_Factor",1000,inversedVolume));
-         _converted = true;
-      }
-
-      public void Visit(IMoBiSimulation simulation)
-      {
-         try
-         {
-            _suspendWarning = true;
-            simulation.BuildConfiguration.AcceptVisitor(this);
-            _dimensionConverter.ConvertDimensionIn(simulation);
-            if (simulation.Results != null) 
-               _dimensionConverter.ConvertDimensionIn(simulation.Results);
-
-            convertSpecialParametersIn(simulation.Model.Root);
-            simulation.HasChanged = true;
-            _converted = true;
-         }
-         finally
-         {
-            _suspendWarning = false;
-         }
-      }
-
-      private void convertSpecialParametersIn(IContainer container)
-      {
-         var inversedLength = _dimensionFactory.Dimension(AppConstants.DimensionNames.INVERSED_LENGTH);
-         convertSpecialParameter(container, "Surface/Volume ratio (blood cells)", 10, inversedLength);
-         convertSpecialParameter(container, "SA proportionality factor", 1.0 / 100, inversedLength);
-      }
-
-      private void convertSpecialParameter(IContainer container, string parameterName, double conversionFactor, IDimension newDimension)
-      {
-         var surfaceVolumeRatioParameter =
-            container.GetAllChildren<IParameter>(p => p.IsNamed(parameterName));
-         surfaceVolumeRatioParameter.Each(p => convertSpecial(p, conversionFactor, newDimension));
-      }
-
-      private void convertSpecial(IParameter parameter, double conversionFactor, IDimension newDimension)
-      {
-         if (parameter.Dimension.Equals(Constants.Dimension.NO_DIMENSION))
-         {
-            parameter.Dimension = newDimension;
-         }
-         if (parameter.Formula.IsConstant())
-         {
-            ((ConstantFormula) parameter.Formula).Value = parameter.Value * conversionFactor;
-            if (parameter.IsFixedValue)
-            {
-               parameter.Value = parameter.Value * conversionFactor;
-            }
-         }
-      }
-
-      public void Visit(SimulationTransfer simulationTransfer)
-      {
-         Visit((IMoBiSimulation) simulationTransfer.Simulation);
-         simulationTransfer.AllObservedData.Each(_dimensionConverter.ConvertDimensionIn);
-         _converted = true;
-      }
-
-      private void createDimensionWarningsForBuildingBlock(IBuildingBlock buildingBlock)
-      {
-         if (_suspendWarning) return;
-         var messages = new List<NotificationMessage>();
-         foreach (var formula in buildingBlock.FormulaCache.Where(x => x.IsExplicit()))
-         {
-            showWarningsFor(formula.DowncastTo<ExplicitFormula>(), buildingBlock, messages);
-         }
-         _eventPublisher.PublishEvent(new ShowNotificationsEvent(messages));
-      }
-
-      private void showWarningsFor(ExplicitFormula formula, IBuildingBlock buildingBlock, List<NotificationMessage> messages)
-      {
-         if (_formulaMapper.FormulaWasConverted(formula.FormulaString))
-            return;
-
-         if (formulaUsesOnlyOneDimension(formula))
-            return;
-
-         bool warningRequired =
-            _dimensionMapper.NeededConversion(formula.Dimension) ||
-            formula.ObjectPaths.Any(objectPath => _dimensionMapper.NeededConversion(objectPath.Dimension));
-
-         if (!warningRequired)
-            return;
-
-         messages.Add(new NotificationMessage(formula, MessageOrigin.Formula, buildingBlock, NotificationType.Warning)
-            {
-               Message = "Dimension check warning",
-               BuildingBlockType = _objectTypeResolver.TypeFor(buildingBlock),
-               ObjectType =ObjectTypes.Formula
-            });
-      }
-
-      private bool formulaUsesOnlyOneDimension(ExplicitFormula formula)
-      {
-         return formula.ObjectPaths.All(x => x.Dimension == formula.Dimension || x.Dimension == Constants.Dimension.NO_DIMENSION);
-      }
-
-      private void convertSpecialParametersIn(IParameterStartValuesBuildingBlock parameterStartValuesBuildingBlock)
-      {
-         var inversedLength = _dimensionFactory.Dimension(AppConstants.DimensionNames.INVERSED_LENGTH);
-         convertSpecialParameter(parameterStartValuesBuildingBlock, "Organism|Surface/Volume ratio (blood cells)", 10, inversedLength);
-         convertSpecialParameter(parameterStartValuesBuildingBlock, "Organism|SA proportionality factor", 1.0 / 100, inversedLength);
-      }
-
-      private void convertSpecialParameter(IParameterStartValuesBuildingBlock parameterStartValuesBuildingBlock, string parameterPath, double conversionFactor, IDimension newDimension)
-      {
-         var surfaceVolumeRatioParameter =
-            parameterStartValuesBuildingBlock.Where(p => p.Path.PathAsString.Equals(parameterPath));
-         surfaceVolumeRatioParameter.Each(p => convertSpecial(p, conversionFactor, newDimension));
-      }
-
-      private void convertSpecial(IParameterStartValue parameterStartValue, double conversionFactor, IDimension newDimension)
-      {
-         if (parameterStartValue.Dimension.Equals(Constants.Dimension.NO_DIMENSION))
-         {
-            parameterStartValue.Dimension = newDimension;
-         }
-         parameterStartValue.StartValue = parameterStartValue.StartValue * conversionFactor;
-      }
-
-      public void Visit(IMoBiProject project)
-      {
-         project.AllObservedData.Each(Visit);
-         _converted = true;
-      }
-   }
-}
\ No newline at end of file
diff --git a/src/MoBi.Core/Serialization/Converter/v3_3/Converter321To331.cs b/src/MoBi.Core/Serialization/Converter/v3_3/Converter321To331.cs
deleted file mode 100644
index 51907a734..000000000
--- a/src/MoBi.Core/Serialization/Converter/v3_3/Converter321To331.cs
+++ /dev/null
@@ -1,366 +0,0 @@
-using System.Collections.Generic;
-using System.Linq;
-using System.Xml.Linq;
-using MoBi.Core.Domain.Model;
-using OSPSuite.Core.Domain;
-using OSPSuite.Core.Domain.Builder;
-using OSPSuite.Core.Domain.Descriptors;
-using OSPSuite.Core.Domain.Formulas;
-using OSPSuite.Core.Domain.Services;
-using OSPSuite.Core.Domain.UnitSystem;
-using OSPSuite.Core.Serialization.Exchange;
-using OSPSuite.Utility.Extensions;
-using OSPSuite.Utility.Visitor;
-
-namespace MoBi.Core.Serialization.Converter.v3_3
-{
-   /// <summary>
-   ///    Converter For MoBi Files From Version 3.2 To 3.3
-   ///    Renaming Elements from Chart To CurveChart
-   ///    Change Entities related to EHC in PK-Sim
-   ///    New Total Drug Mass Parameter
-   /// </summary>
-   public class Converter321To331 : IMoBiObjectConverter,
-      IVisitor<IEventGroupBuildingBlock>,
-      IVisitor<IPassiveTransportBuildingBlock>,
-      IVisitor<IModelCoreSimulation>,
-      IVisitor<ISpatialStructure>,
-      IVisitor<IObserverBuildingBlock>,
-      IVisitor<IMoleculeBuildingBlock>,
-      IVisitor<IReactionBuildingBlock>,
-      IVisitor<SimulationTransfer>
-
-   {
-      public static string EHCStartEvent = "EHC_Start_Event";
-      public static string EHCStopEvent = "EHC_Stop_Event";
-      public static readonly string GallbladderEmptyingRate = "Gallbladder emptying rate";
-      public static string GallbladderEmptying = "GallbladderEmptying";
-      public static string Gallbladder = "Gallbladder";
-      public static string GallbladderEmptyingOldFormula = "GallbladderEmptyingRate";
-      public static string GallbladderEmptyingNewFormula = "EHC_Active ? ln(2) / EHC_Halftime * M * EHC_EjectionFraction : 0";
-      public static string GallbladderEmptyingActive = "Gallbladder emptying active";
-      public static string GallbladderEjectionFraction = "Gallbladder ejection fraction";
-      public static string GallbladderEjectionHalfTime = "Gallbladder ejection half-time";
-      public static string GallbladderEmptyingActiveAlias = "EHC_Active";
-      public static string GallbladderEjectionFractionAlias = "EHC_EjectionFraction";
-      public static string GallbladderEjectionHalfTimeAlias = "EHC_Halftime";
-      public static ObjectPath GallbladderEmptyingRatePath = new ObjectPath(new[] {"Organism", "Gallbladder", "Gallbladder emptying rate"});
-      private readonly IMoBiContext _context;
-      public static string TotalDrugmassOld = "TotalDrugMass";
-      public static string TotalDrugmassNew = "Total drug mass";
-      public static string DrugMass = "DrugMass";
-      public static string Applications = "Applications";
-      private readonly IFormulaTask _formulaTask;
-      private bool _converted;
-
-      public Converter321To331(IMoBiContext context, IFormulaTask formulaTask)
-      {
-         _context = context;
-         _formulaTask = formulaTask;
-      }
-
-      public bool IsSatisfiedBy(int version) => version == ProjectVersions.V3_2_1;
-
-      public (int convertedToVersion, bool conversionHappened) Convert(object objectToConvert, IMoBiProject project)
-      {
-         _converted = false;
-         this.Visit(objectToConvert);
-         return (ProjectVersions.V3_3_1, _converted);
-      }
-
-      public (int convertedToVersion, bool conversionHappened) ConvertXml(XElement element, IMoBiProject project)
-      {
-         _converted = false;
-         convertChartToCurveChartElement(element);
-         return (ProjectVersions.V3_3_1, _converted);
-      }
-
-      private void convertChartToCurveChartElement(XElement element)
-      {
-         var charts = element.DescendantsAndSelf("Chart");
-         charts.Each(c =>
-         {
-            c.Name = "CurveChart";
-            _converted = true;
-         });
-      }
-
-      public void Visit(IEventGroupBuildingBlock eventGroupBuildingBlock)
-      {
-         updateEHCEvents(eventGroupBuildingBlock);
-         eventGroupBuildingBlock.Each(updateTotalDrugMass);
-         updateAllParameters(eventGroupBuildingBlock.SelectMany(c => c.GetAllChildren<IParameter>()));
-         _converted = true;
-      }
-
-      private void updateTotalDrugMass(IContainer container)
-      {
-         if (container == null) return;
-         var allProtocolSchemaItems = container.GetAllContainersAndSelf<IContainer>(c => c.Name.Equals("ProtocolSchemaItem"));
-         foreach (var protocolSchemaItem in allProtocolSchemaItems)
-         {
-            var drugMassParameter = protocolSchemaItem.GetSingleChildByName<IParameter>(DrugMass);
-            if (drugMassParameter != null) drugMassParameter.AddTag(ObjectPathKeywords.MOLECULE);
-         }
-         var parameter = container.GetSingleChildByName<IParameter>(TotalDrugmassOld);
-         if (parameter != null)
-            container.RemoveChild(parameter);
-      }
-
-      private void updateEHCEvents(IEventGroupBuildingBlock eventGroupBuildingBlock)
-      {
-         var startEvents =
-            eventGroupBuildingBlock.SelectMany(eg => eg.GetAllChildren<IEventBuilder>(eb => eb.Name.Equals(EHCStartEvent)));
-         startEvents.Each(se => changeAssignments(se, false, 1));
-         var stopEvents =
-            eventGroupBuildingBlock.SelectMany(eg => eg.GetAllChildren<IEventBuilder>(eb => eb.Name.Equals(EHCStopEvent)));
-         stopEvents.Each(se => changeAssignments(se, true, 0));
-      }
-
-      private void changeAssignments(IEventBuilder startEvent, bool useAsValue, double value)
-      {
-         var assignment =
-            startEvent.Assignments.FirstOrDefault(
-               a => a.ObjectPath.Equals(GallbladderEmptyingRatePath));
-         changeAssignment(useAsValue, value, assignment);
-      }
-
-      private void changeAssignments(IEvent startEvent, bool useAsValue, double value, IObjectPath gallbladderEmptyingRatePath)
-      {
-         var assignment =
-            startEvent.Assignments.FirstOrDefault(
-               a => a.ObjectPath.Equals(gallbladderEmptyingRatePath));
-
-         changeAssignment(useAsValue, value, assignment);
-      }
-
-      private void changeAssignment(bool useAsValue, double value, IAssignment assignment)
-      {
-         if (assignment == null) return;
-         assignment.ObjectPath.Replace(GallbladderEmptyingRate, GallbladderEmptyingActive);
-         assignment.UseAsValue = useAsValue;
-         assignment.Formula = _context.Create<ConstantFormula>().WithValue(value);
-      }
-
-      public void Visit(IPassiveTransportBuildingBlock passiveTransportBuildingBlock)
-      {
-         var transpotBuilder = passiveTransportBuildingBlock.FirstOrDefault(isOldGallbladderEmptyingTransport);
-
-         if (transpotBuilder != null)
-         {
-            var kinetic = ((ExplicitFormula) transpotBuilder.Formula);
-            updateEHCKinetic(kinetic, ObjectPathKeywords.MOLECULE);
-         }
-         updateAllParameters(passiveTransportBuildingBlock.SelectMany(c => c.GetAllChildren<IParameter>()));
-         _converted = true;
-      }
-
-      private void updateEHCKinetic(ExplicitFormula kinetic, string moleculeName)
-      {
-         kinetic.FormulaString = GallbladderEmptyingNewFormula;
-         var amount = _context.DimensionFactory.Dimension(Constants.Dimension.AMOUNT);
-         var noDimension = _context.DimensionFactory.NoDimension;
-         var time = _context.DimensionFactory.Dimension(Constants.Dimension.TIME);
-         kinetic.ClearObjectPaths();
-         kinetic.AddObjectPath(
-            _context.ObjectPathFactory.CreateFormulaUsablePathFrom(Constants.ORGANISM, Gallbladder,
-                  moleculeName)
-               .WithAlias("M")
-               .WithDimension(amount));
-         kinetic.AddObjectPath(
-            _context.ObjectPathFactory.CreateFormulaUsablePathFrom(Constants.ORGANISM, Gallbladder,
-                  GallbladderEmptyingActive)
-               .WithAlias(GallbladderEmptyingActiveAlias)
-               .WithDimension(noDimension));
-         kinetic.AddObjectPath(
-            _context.ObjectPathFactory.CreateFormulaUsablePathFrom(Constants.ORGANISM, Gallbladder,
-                  GallbladderEjectionFraction)
-               .WithAlias(GallbladderEjectionFractionAlias)
-               .WithDimension(amount));
-         kinetic.AddObjectPath(
-            _context.ObjectPathFactory.CreateFormulaUsablePathFrom(Constants.ORGANISM, Gallbladder,
-                  GallbladderEjectionHalfTime)
-               .WithAlias(GallbladderEjectionHalfTimeAlias)
-               .WithDimension(time));
-      }
-
-      private static bool isOldGallbladderEmptyingTransport(ITransportBuilder transpotBuilder)
-      {
-         return transpotBuilder.Name.Equals(GallbladderEmptying) && ((ExplicitFormula) transpotBuilder.Formula).FormulaString.Equals(GallbladderEmptyingOldFormula);
-      }
-
-      private static bool isOldGallbladderEmptyingTransport(ITransport transport)
-      {
-         return transport.Name.Equals(GallbladderEmptying) && ((ExplicitFormula) transport.Formula).FormulaString.Equals(GallbladderEmptyingOldFormula);
-      }
-
-      public void Visit(IModelCoreSimulation simulation)
-      {
-         simulation.BuildConfiguration.AllBuildingBlocks.Each(this.Visit);
-
-         var root = simulation.Model.Root;
-         var organism = root.GetSingleChildByName<IContainer>(Constants.ORGANISM);
-         if (organism == null) return;
-         //Add new parameter gall bladder emptying active
-         var parameter = addGallBladderEmptyingActiveParameter(organism);
-         if (parameter == null) return;
-
-         // Genearate EHC_Event assingment path in simulaton
-         var gallbladderEmptyingRatePathSimulation = GallbladderEmptyingRatePath.Clone<IObjectPath>();
-         gallbladderEmptyingRatePathSimulation.AddAtFront(root.Name);
-
-         // change  ehc events
-         var startEvents = root.GetAllChildren<IEvent>(eb => eb.Name.Equals(EHCStartEvent));
-         startEvents.Each(se => changeAssignments(se, false, 1, gallbladderEmptyingRatePathSimulation));
-         startEvents.Each(se => (se.Assignments).Each(a => ((EventAssignment) a).ChangedEntity = null));
-
-         var stopEvents = root.GetAllChildren<IEvent>(eb => eb.Name.Equals(EHCStopEvent));
-         stopEvents.Each(se => changeAssignments(se, true, 0, gallbladderEmptyingRatePathSimulation));
-         stopEvents.Each(se => se.Assignments.Each(a => ((EventAssignment) a).ChangedEntity = null));
-
-         // Update gall bladder emptying kinetics
-         var tranports = simulation.Model.Neighborhoods.GetAllChildren<ITransport>(isOldGallbladderEmptyingTransport);
-         tranports.Each(t => updateGallBladderEmptyingInSimulation(t, root.Name));
-
-         updateTotalDrugMassHandling(simulation, root);
-
-         updateAllParameters(root.GetAllChildren<IParameter>());
-         _formulaTask.ExpandDynamicFormulaIn(simulation.Model);
-         _converted = true;
-      }
-
-      private void updateTotalDrugMassHandling(IModelCoreSimulation simulation, IContainer root)
-      {
-         var amountDimension = _context.DimensionFactory.Dimension(Constants.Dimension.AMOUNT);
-         updateTotalDrugMass(root.GetSingleChildByName<IContainer>(Applications));
-         var oldDrugMassPath = new ObjectPath(new[] {simulation.Model.Root.Name, Applications, TotalDrugmassOld});
-         var allObserver = root.GetAllChildren<IObserver>().ToList();
-         updateTotalDrugMassReferences(allObserver, oldDrugMassPath);
-         replaceMoleculeKeyword(allObserver);
-         var allMoleculeNames = simulation.BuildConfiguration.Molecules.Select(mb => mb.Name).ToArray();
-         var allMoleculeContainer = root.GetChildren<IContainer>().Where(c => allMoleculeNames.Contains(c.Name));
-         allMoleculeContainer.Each(mc => mc.Add(createTotalDrugMassParameter(createTotalDrugMassFormula(amountDimension), amountDimension)));
-      }
-
-      private void replaceMoleculeKeyword(IEnumerable<IObserver> allObserver)
-      {
-         foreach (var observer in allObserver)
-         {
-            observer.Formula.ObjectPaths.Each(op => op.Replace(ObjectPathKeywords.MOLECULE, observer.ParentContainer.Name));
-         }
-      }
-
-      private void updateGallBladderEmptyingInSimulation(ITransport transport, string rootName)
-      {
-         var kinetic = (ExplicitFormula) transport.Formula;
-         var moleculeName = transport.ParentContainer.Name;
-         updateEHCKinetic(kinetic, moleculeName);
-         //Add Root Name to all Paths
-         kinetic.ObjectPaths.Each(ob => ob.AddAtFront(rootName));
-      }
-
-      public void Visit(ISpatialStructure spatialStructure)
-      {
-         var organism = spatialStructure.TopContainers.FirstOrDefault(tc => tc.Name.Equals(Constants.ORGANISM));
-         if (organism == null) return;
-         var param = addGallBladderEmptyingActiveParameter(organism);
-         if (param != null)
-            spatialStructure.FormulaCache.Add(param.Formula);
-
-
-         updateAllParameters(spatialStructure.SelectMany(c => c.GetAllChildren<IParameter>()));
-         _converted = true;
-      }
-
-      private IParameter addGallBladderEmptyingActiveParameter(IContainer organism)
-      {
-         var gallbladder = organism.GetSingleChildByName<IContainer>(Gallbladder);
-         if (gallbladder == null) return null;
-         var noDimension = _context.DimensionFactory.NoDimension;
-
-         var formula =_context.Create<ExplicitFormula>()
-               .WithName($"PARAM_{GallbladderEmptyingActive}")
-               .WithFormulaString("0")
-               .WithDimension(noDimension);
-
-         var parameter =_context.Create<IParameter>()
-               .WithName(GallbladderEmptyingActive)
-               .WithFormula(formula)
-               .WithDimension(noDimension);
-         gallbladder.Add(parameter);
-         gallbladder.RemoveChild(gallbladder.GetSingleChildByName<IParameter>(GallbladderEmptyingRate));
-         return parameter;
-      }
-
-      public void Visit(IObserverBuildingBlock objToVisit)
-      {
-         var oldDrugMassPath = new ObjectPath(new[] {Applications, TotalDrugmassOld});
-         updateTotalDrugMassReferences(objToVisit, oldDrugMassPath);
-         _converted = true;
-      }
-
-      private void updateTotalDrugMassReferences(IEnumerable<IUsingFormula> objToVisit, IObjectPath oldDrugMassPath)
-      {
-         foreach (var observerBuilder in objToVisit)
-         {
-            var pathsToChange =
-               observerBuilder.Formula.ObjectPaths.Where(op => op.PathAsString.Equals(oldDrugMassPath.PathAsString))
-                  .ToList();
-            pathsToChange.Each(p => p.Replace(Applications, ObjectPathKeywords.MOLECULE));
-            pathsToChange.Each(p => p.Replace(TotalDrugmassOld, TotalDrugmassNew));
-         }
-      }
-
-      public void Visit(IMoleculeBuildingBlock moleculeBuildingBlock)
-      {
-         var amountDimension = _context.DimensionFactory.Dimension(Constants.Dimension.AMOUNT);
-         var formula = createTotalDrugMassFormula(amountDimension);
-         foreach (var moleculeBuilder in moleculeBuildingBlock)
-         {
-            moleculeBuilder.Add(
-               createTotalDrugMassParameter(formula, amountDimension));
-         }
-         updateAllParameters(moleculeBuildingBlock.SelectMany(mb => mb.GetAllChildren<IParameter>()));
-         moleculeBuildingBlock.AddFormula(formula);
-         _converted = true;
-      }
-
-      private SumFormula createTotalDrugMassFormula(IDimension amountDimension)
-      {
-         var formula =
-            _context.Create<SumFormula>()
-               .WithName("PARAM_TotalDrugMass")
-               .WithDimension(amountDimension);
-         formula.Criteria.Add(new MatchTagCondition(ObjectPathKeywords.MOLECULE));
-         formula.Criteria.Add(new MatchTagCondition(DrugMass));
-         return formula;
-      }
-
-      private IParameter createTotalDrugMassParameter(SumFormula formula, IDimension amountDimension)
-      {
-         return _context.Create<IParameter>()
-            .WithName(TotalDrugmassNew)
-            .WithMode(ParameterBuildMode.Property)
-            .WithFormula(formula)
-            .WithDimension(amountDimension)
-            .WithGroup(Constants.Groups.MOBI);
-      }
-
-      private void updateAllParameters(IEnumerable<IParameter> allParameter)
-      {
-         allParameter.Each(p => p.GroupName = Constants.Groups.MOBI);
-      }
-
-      public void Visit(IReactionBuildingBlock reactionBuildingBlock)
-      {
-         updateAllParameters(reactionBuildingBlock.SelectMany(c => c.GetAllChildren<IParameter>()));
-         _converted = true;
-      }
-
-      public void Visit(SimulationTransfer objToVisit)
-      {
-         Visit(objToVisit.Simulation);
-         _converted = true;
-      }
-   }
-}
\ No newline at end of file
diff --git a/src/MoBi.Core/Serialization/Converter/v3_4/Converter33To34.cs b/src/MoBi.Core/Serialization/Converter/v3_4/Converter33To34.cs
deleted file mode 100644
index b286f75df..000000000
--- a/src/MoBi.Core/Serialization/Converter/v3_4/Converter33To34.cs
+++ /dev/null
@@ -1,19 +0,0 @@
-using System.Xml.Linq;
-using MoBi.Core.Domain.Model;
-using OSPSuite.Core.Converter.v5_4;
-
-namespace MoBi.Core.Serialization.Converter.v3_4
-{
-   public class Converter33To34 : Converter531To541, IMoBiObjectConverter
-   {
-      public (int convertedToVersion, bool conversionHappened) Convert(object objectToUpdate, IMoBiProject project)
-      {
-         return Convert(objectToUpdate);
-      }
-
-      public (int convertedToVersion, bool conversionHappened) ConvertXml(XElement element, IMoBiProject project)
-      {
-         return ConvertXml(element);
-      }
-   }
-}
\ No newline at end of file
diff --git a/src/MoBi.Core/Serialization/Converter/v3_5/Converter341To351.cs b/src/MoBi.Core/Serialization/Converter/v3_5/Converter341To351.cs
deleted file mode 100644
index 6f473f181..000000000
--- a/src/MoBi.Core/Serialization/Converter/v3_5/Converter341To351.cs
+++ /dev/null
@@ -1,326 +0,0 @@
-using System.Linq;
-using System.Xml.Linq;
-using MoBi.Assets;
-using MoBi.Core.Domain.Builder;
-using MoBi.Core.Domain.Model;
-using MoBi.Core.Domain.Services;
-using OSPSuite.Assets;
-using OSPSuite.Core.Converter.v5_5;
-using OSPSuite.Core.Domain;
-using OSPSuite.Core.Domain.Builder;
-using OSPSuite.Core.Domain.Data;
-using OSPSuite.Core.Domain.Formulas;
-using OSPSuite.Core.Domain.UnitSystem;
-using OSPSuite.Core.Serialization.Xml.Extensions;
-using OSPSuite.Serializer.Xml.Extensions;
-using OSPSuite.Utility.Extensions;
-using OSPSuite.Utility.Visitor;
-
-namespace MoBi.Core.Serialization.Converter.v3_5
-{
-   public class Converter341To351 : IMoBiObjectConverter,
-      IVisitor<DataRepository>,
-      IVisitor<IModelCoreSimulation>,
-      IVisitor<IMoleculeBuildingBlock>,
-      IVisitor<ISpatialStructure>,
-      IVisitor<IBuildConfiguration>,
-      IVisitor<IPassiveTransportBuildingBlock>
-
-   {
-      private readonly Converter541To551 _coreConverter;
-      private readonly ICloneManagerForSimulation _cloneManager;
-      private readonly IParameterFactory _parameterFactory;
-      private readonly ISimulationSettingsFactory _simulationSettingsFactory;
-      private readonly IObjectBaseFactory _objectBaseFactory;
-      private readonly IDistributionFormulaFactory _distributionFormulaFactory;
-      private readonly IMoBiFormulaTask _formulaTask;
-      private readonly IDimensionFactory _dimensionFactory;
-      private readonly IObjectPathFactory _objectPathFactory;
-      private IMoBiProject _project;
-
-      //this fields indicate if a MoBi simulation is being loaded (typically from project) or if a pkml simulation is being loaded. 
-      //in the latter, we do not add the template simulation settings to the project
-      private bool _loadingMoBiSimulation;
-
-      private bool _converted;
-
-      private const string EFFECTIVE_SURFACE_AREA_VARIABILITY_FACTOR = "Effective surface area variability factor";
-      private const string EFFECTIVE_SURFACE_AREA_ENHANCEMENT_FACTOR = "Effective surface area enhancement factor";
-      private const string EFFECTIVE_SURFACE_AREA = "Effective surface area";
-      private const string GEOMETRIC_SURFACE_AREA = "Geometric surface area";
-
-      public Converter341To351(Converter541To551 coreConverter, ICloneManagerForSimulation cloneManager,
-         IParameterFactory parameterFactory, ISimulationSettingsFactory simulationSettingsFactory,
-         IObjectBaseFactory objectBaseFactory, IDistributionFormulaFactory distributionFormulaFactory,
-         IMoBiFormulaTask formulaTask, IDimensionFactory dimensionFactory, IObjectPathFactory objectPathFactory)
-      {
-         _coreConverter = coreConverter;
-         _cloneManager = cloneManager;
-         _parameterFactory = parameterFactory;
-         _simulationSettingsFactory = simulationSettingsFactory;
-         _objectBaseFactory = objectBaseFactory;
-         _distributionFormulaFactory = distributionFormulaFactory;
-         _formulaTask = formulaTask;
-         _dimensionFactory = dimensionFactory;
-         _objectPathFactory = objectPathFactory;
-      }
-
-      public bool IsSatisfiedBy(int version) => version == ProjectVersions.V3_4_1;
-
-      public (int convertedToVersion, bool conversionHappened) Convert(object objectToUpdate, IMoBiProject project)
-      {
-         try
-         {
-            _project = project;
-            _converted = false;
-            var (_, coreConversionHappened) = _coreConverter.Convert(objectToUpdate);
-            this.Visit(objectToUpdate);
-            return (ProjectVersions.V3_5_1, _converted || coreConversionHappened);
-         }
-         finally
-         {
-            _project = null;
-         }
-      }
-
-      public (int convertedToVersion, bool conversionHappened) ConvertXml(XElement element, IMoBiProject project)
-      {
-         _coreConverter.ConvertXml(element);
-
-         element.DescendantsAndSelfNamed(AppConstants.XmlNames.BuildConfiguration).Each(convertBuildConfigurationElement);
-         element.DescendantsAndSelfNamed("Simulation", AppConstants.XmlNames.MoBiSimulation).Each(convertMoBiSimulationElement);
-
-         //only happens when loading an actual MoBiSimulation from a project
-         _loadingMoBiSimulation = (element.Name == AppConstants.XmlNames.MoBiSimulation);
-
-         //too many conversion happening here! set to true for compatibility
-         return (ProjectVersions.V3_5_1, true);
-      }
-
-      private void convertBuildConfigurationElement(XElement buildConfigurationElement)
-      {
-         if (buildConfigurationElement == null) return;
-         //create an empty element. This is enough to instantiate the object 
-         buildConfigurationElement.Add(new XElement(AppConstants.XmlNames.SimulationSettingsInfo));
-         _converted = true;
-
-      }
-
-      private void convertMoBiSimulationElement(XElement element)
-      {
-         const string oldParameterIdetificationWorkingDirectory = "parameterIdetificationWorkingDirectory";
-         const string newParameterIdentificationWorkingDirectory = "parameterIdentificationWorkingDirectory";
-
-         _coreConverter.ConvertSimuationElement(element);
-
-         var buildConfigurationElement = element.Element(AppConstants.XmlNames.BuildConfiguration);
-         if (buildConfigurationElement == null) return;
-
-         const string originalBuildingBlockId = "originalBuildingBlockId";
-         var query = buildConfigurationElement.Descendants()
-            .Where(x => x.Attribute(originalBuildingBlockId) != null)
-            .Select(x => new {Element = x, Attr = x.Attribute(originalBuildingBlockId)});
-
-         foreach (var buildingBlockInfoElement in query.ToList())
-         {
-            buildingBlockInfoElement.Element.AddAttribute("templateBuildingBlockId", buildingBlockInfoElement.Attr.Value);
-            buildingBlockInfoElement.Attr.Remove();
-         }
-
-
-         var oldAttribute = element.Attribute(oldParameterIdetificationWorkingDirectory);
-         if (oldAttribute == null)
-            return;
-
-         element.AddAttribute(newParameterIdentificationWorkingDirectory, oldAttribute.Value);
-         oldAttribute.Remove();
-      }
-
-      public void Visit(IModelCoreSimulation simulation)
-      {
-         var mobiSimulation = simulation as IMoBiSimulation;
-         if (mobiSimulation == null) return;
-
-         //historical results will be deserialized in a separate call
-         Visit(mobiSimulation.Results);
-         Visit(mobiSimulation.BuildConfiguration);
-         addSimulationSettingsTemplateToProject(mobiSimulation);
-         updateGlobalReactionContainerIcon(simulation);
-      }
-
-      private void updateGlobalReactionContainerIcon(IModelCoreSimulation simulation)
-      {
-         simulation.Model.Root.GetChildren<IContainer>(c => c.ContainerType == ContainerType.Reaction)
-            .Each(c => c.Icon = IconNames.REACTION);
-      }
-
-      private void addSimulationSettingsTemplateToProject(IMoBiSimulation mobiSimulation)
-      {
-         if (!_loadingMoBiSimulation) return;
-         var simulationSettingsInfo = mobiSimulation.MoBiBuildConfiguration.SimulationSettingsInfo;
-         var templateSimulationSettings = _cloneManager.CloneBuidingBlock(simulationSettingsInfo.BuildingBlock);
-         simulationSettingsInfo.TemplateBuildingBlock = templateSimulationSettings;
-         _project.AddBuildingBlock(templateSimulationSettings);
-      }
-
-      public void Visit(DataRepository dataRepository)
-      {
-         _coreConverter.UpdateQuantityTypeForDataRepository(dataRepository);
-      }
-
-      public void Visit(IMoleculeBuildingBlock moleculeBuildingBlock)
-      {
-         foreach (var moleculeBuilder in moleculeBuildingBlock.Where(x => !x.ContainsName(Constants.Parameters.CONCENTRATION)).ToList())
-         {
-            var concentrationParameter = _parameterFactory.CreateConcentrationParameter(moleculeBuildingBlock.FormulaCache);
-            moleculeBuilder.AddParameter(concentrationParameter);
-         }
-
-         convertFormulaReferencingAeffIn(moleculeBuildingBlock);
-      }
-
-      public void Visit(ISpatialStructure spatialStructure)
-      {
-         foreach (var container in spatialStructure.PhysicalContainers.Where(x => !x.ContainsName(Constants.Parameters.VOLUME)).ToList())
-         {
-            container.Add(_parameterFactory.CreateVolumeParameter());
-         }
-         addVariabilityParameterIn(spatialStructure);
-         addEffectiveSurfaceAreaParameter(spatialStructure);
-         convertFormulaReferencingAeffIn(spatialStructure);
-      }
-
-      private static void replaceAgeomXAeffFactorWithAeffIn(ExplicitFormula formula)
-      {
-         if (!formula.FormulaString.Contains("Ageom * AeffFactor") && !formula.FormulaString.Contains("Ageom*AeffFactor")) return;
-
-         if (formula.IsNamed("PARAM_EffectiveSurfaceArea")) return;
-
-         formula.FormulaString = formula.FormulaString.Replace("Ageom * AeffFactor", "Aeff").Replace("Ageom*AeffFactor", "Aeff");
-         var objectPath = formula.ObjectPaths.Find(x => x.Alias == "Ageom");
-         objectPath.Remove(GEOMETRIC_SURFACE_AREA);
-         objectPath.Add(EFFECTIVE_SURFACE_AREA);
-         objectPath.Alias = "Aeff";
-
-         var aeffFactorObjectPath = formula.ObjectPaths.Find(x => x.Alias == "AeffFactor");
-         formula.RemoveObjectPath(aeffFactorObjectPath);
-      }
-
-      public void Visit(IBuildConfiguration buildConfiguration)
-      {
-         Visit(buildConfiguration.Molecules);
-         Visit(buildConfiguration.SpatialStructure);
-         Visit(buildConfiguration.PassiveTransports);
-
-         if (buildConfiguration.SimulationSettings == null)
-            buildConfiguration.SimulationSettings = _simulationSettingsFactory.CreateDefault();
-      }
-
-      private void addEffectiveSurfaceAreaParameter(ISpatialStructure spatialStructure)
-      {
-         var organism = getOrganism(spatialStructure);
-         if (organism == null) return;
-         var lumen = organism.EntityAt<IContainer>("Lumen");
-         if (lumen == null) return;
-
-         var variabilityFactor = lumen.EntityAt<IParameter>(EFFECTIVE_SURFACE_AREA_VARIABILITY_FACTOR);
-         var area = _dimensionFactory.Dimension("Area");
-         foreach (var containerWithSurfaceArea in organism.GetAllChildren<IContainer>(c => c.ContainsName(EFFECTIVE_SURFACE_AREA_ENHANCEMENT_FACTOR)))
-         {
-            var effectiveSurfaceArea = _objectBaseFactory.Create<IParameter>()
-               .WithName(EFFECTIVE_SURFACE_AREA)
-               .WithDimension(area)
-               .WithGroup("GI_ANATOMY_AREA")
-               .WithDescription("Effective surface area of GI segment");
-
-            var geometricSurfaceArea = containerWithSurfaceArea.EntityAt<IParameter>(GEOMETRIC_SURFACE_AREA);
-            if (geometricSurfaceArea == null)
-               continue;
-
-            var effectiveSurfaceAreaEnahncementFactor = containerWithSurfaceArea.EntityAt<IParameter>(EFFECTIVE_SURFACE_AREA_ENHANCEMENT_FACTOR);
-
-            containerWithSurfaceArea.Add(effectiveSurfaceArea);
-
-            var formula = spatialStructure.FormulaCache.FindByName("PARAM_EffectiveSurfaceArea") as ExplicitFormula;
-            if (formula == null)
-            {
-               formula = _formulaTask.CreateNewFormula<ExplicitFormula>(area).WithName("PARAM_EffectiveSurfaceArea");
-               formula.AddObjectPath(_objectPathFactory.CreateRelativeFormulaUsablePath(effectiveSurfaceArea, variabilityFactor).WithAlias("AeffVariabilityFactor"));
-               formula.AddObjectPath(_objectPathFactory.CreateRelativeFormulaUsablePath(effectiveSurfaceArea, geometricSurfaceArea).WithAlias("Ageom"));
-               formula.AddObjectPath(_objectPathFactory.CreateRelativeFormulaUsablePath(effectiveSurfaceArea, effectiveSurfaceAreaEnahncementFactor).WithAlias("AeffFactor"));
-               formula.FormulaString = "Ageom * AeffFactor * AeffVariabilityFactor";
-               spatialStructure.AddFormula(formula);
-            }
-
-            effectiveSurfaceArea.Formula = formula;
-         }
-      }
-
-      private void addVariabilityParameterIn(ISpatialStructure spatialStructure)
-      {
-         var organism = getOrganism(spatialStructure);
-         if (organism == null) return;
-
-         var lumen = organism.EntityAt<IContainer>("Lumen");
-         if (lumen == null) return;
-
-         var parameter = _objectBaseFactory.Create<IDistributedParameter>()
-            .WithName(EFFECTIVE_SURFACE_AREA_VARIABILITY_FACTOR)
-            .WithDescription("Effective surface area variability factor");
-
-         parameter.WithGroup("GI_ANATOMY_AEFF_FACTOR");
-
-         var meanParameter = effectiveSurfaceAreaMeanParameter();
-         var deviationParameter = effectiveSurfaceAreaDeviationParameter();
-         var percentileParameter = effectiveSurfaceAreaPercentileParameter();
-         parameter.Add(meanParameter);
-         parameter.Add(deviationParameter);
-         parameter.Add(percentileParameter);
-         parameter.Formula = _distributionFormulaFactory.CreateLogNormalDistributionFormulaFor(parameter, meanParameter, deviationParameter);
-
-         lumen.Add(parameter);
-      }
-
-      private static IContainer getOrganism(ISpatialStructure spatialStructure)
-      {
-         return spatialStructure.TopContainers.FindByName(Constants.ORGANISM);
-      }
-
-      private IParameter effectiveSurfaceAreaDeviationParameter()
-      {
-         return distributionParameter(Constants.Distribution.GEOMETRIC_DEVIATION, 1.6);
-      }
-
-      private IParameter effectiveSurfaceAreaMeanParameter()
-      {
-         return distributionParameter(Constants.Distribution.MEAN, 1);
-      }
-
-      private IParameter effectiveSurfaceAreaPercentileParameter()
-      {
-         return distributionParameter(Constants.Distribution.PERCENTILE, 0.5);
-      }
-
-      private IParameter distributionParameter(string name, double value)
-      {
-         var dimension = _dimensionFactory.Dimension(Constants.Dimension.DIMENSIONLESS);
-         var meanFormula = _formulaTask.CreateNewFormula<ConstantFormula>(dimension).WithValue(value);
-         return _objectBaseFactory.Create<IParameter>()
-            .WithName(name)
-            .WithFormula(meanFormula);
-      }
-
-      public void Visit(IPassiveTransportBuildingBlock passiveTransportBuilding)
-      {
-         convertFormulaReferencingAeffIn(passiveTransportBuilding);
-      }
-
-      private void convertFormulaReferencingAeffIn(IBuildingBlock buildingBlock)
-      {
-         foreach (var explicitFormula in buildingBlock.FormulaCache.OfType<ExplicitFormula>())
-         {
-            replaceAgeomXAeffFactorWithAeffIn(explicitFormula);
-         }
-      }
-   }
-}
\ No newline at end of file
diff --git a/src/MoBi.Core/Serialization/Converter/v6_0/Converter36To601.cs b/src/MoBi.Core/Serialization/Converter/v6_0/Converter36To601.cs
deleted file mode 100644
index 01104e45e..000000000
--- a/src/MoBi.Core/Serialization/Converter/v6_0/Converter36To601.cs
+++ /dev/null
@@ -1,102 +0,0 @@
-using System.Xml.Linq;
-using MoBi.Assets;
-using MoBi.Core.Domain.Model;
-using OSPSuite.Core.Converter.v6_0;
-using OSPSuite.Core.Domain;
-using OSPSuite.Core.Domain.Data;
-using OSPSuite.Core.Serialization.Xml.Extensions;
-using OSPSuite.Utility.Extensions;
-using OSPSuite.Utility.Visitor;
-
-namespace MoBi.Core.Serialization.Converter.v6_0
-{
-   public class Converter36To601 : IMoBiObjectConverter,
-      IVisitor<IMoBiProject>
-   {
-      private readonly Converter56To601 _coreConverter56To601;
-      private static readonly string RHS_DIMENSION_OLD_SUFFIX = " per Time";
-      private static readonly string MOL_WEIGHT = "MolWeight";
-      private bool _converted;
-
-      public Converter36To601(Converter56To601 coreConverter56To601)
-      {
-         _coreConverter56To601 = coreConverter56To601;
-      }
-
-      public bool IsSatisfiedBy(int version) => version == ProjectVersions.V3_6_1;
-
-      public (int convertedToVersion, bool conversionHappened) Convert(object objectToUpdate, IMoBiProject project)
-      {
-         _converted = false;
-         var (_, coreConversionHappened) = _coreConverter56To601.Convert(objectToUpdate);
-         this.Visit(objectToUpdate);
-         return (ProjectVersions.V6_0_1, _converted || coreConversionHappened);
-      }
-
-      public (int convertedToVersion, bool conversionHappened) ConvertXml(XElement element, IMoBiProject project)
-      {
-         _converted = false;
-         var (_, coreConversionHappened) = _coreConverter56To601.ConvertXml(element);
-         element.DescendantsAndSelfNamed("DisplayUnitMap").Each(displayUnitMapElement => convertPerTimeDimension(displayUnitMapElement, "dimension"));
-         element.DescendantsAndSelfNamed("Formula").Each(displayUnitMapElement => convertPerTimeDimension(displayUnitMapElement, "dim"));
-         element.DescendantsAndSelfNamed("Map").Each(displayUnitMapElement => convertPerTimeDimension(displayUnitMapElement, "s"));
-         element.DescendantsAndSelfNamed("Parameter").Each(convertParameterQuantityType);
-         return (ProjectVersions.V6_0_1, _converted || coreConversionHappened);
-      }
-
-      public void Visit(IMoBiProject project)
-      {
-         foreach (var observedData in project.AllObservedData)
-         {
-            observedData.ExtendedProperties.Remove(MOL_WEIGHT);
-            updateObservedDataPaths(observedData);
-            _converted = true;
-         }
-      }
-
-      private void convertParameterQuantityType(XElement parameterElement)
-      {
-         var quantityTypeAttribute = parameterElement.Attribute("quantityType");
-         if (quantityTypeAttribute == null)
-            return;
-
-         quantityTypeAttribute.SetValue(QuantityType.Parameter.ToString());
-         _converted = true;
-      }
-
-      private void convertPerTimeDimension(XElement displayUnitMapElement, XName dimensionAttributeName)
-      {
-         var dimensionAttribute = displayUnitMapElement.Attribute(dimensionAttributeName);
-         if (dimensionAttribute == null)
-            return;
-
-         dimensionAttribute.SetValue(dimensionNameFrom(dimensionAttribute.Value));
-         _converted = true;
-      }
-
-      private string dimensionNameFrom(string dimensionName)
-      {
-         if (string.IsNullOrEmpty(dimensionName))
-            return dimensionName;
-
-         if (!dimensionName.Contains(RHS_DIMENSION_OLD_SUFFIX))
-            return dimensionName;
-
-         return dimensionName.Replace(RHS_DIMENSION_OLD_SUFFIX, AppConstants.RHSDimensionSuffix);
-      }
-
-      private void updateObservedDataPaths(DataRepository repository)
-      {
-         var baseGrid = repository.BaseGrid;
-         var baseGridName = baseGrid.Name.Replace(ObjectPath.PATH_DELIMITER, "\\");
-         baseGrid.QuantityInfo = new QuantityInfo(baseGrid.Name, new[] {repository.Name, baseGridName}, QuantityType.Time);
-
-         foreach (var col in repository.AllButBaseGrid())
-         {
-            var colName = col.Name.Replace(ObjectPath.PATH_DELIMITER, "\\");
-            var quantityInfo = new QuantityInfo(col.Name, new[] {repository.Name, colName}, QuantityType.Undefined);
-            col.QuantityInfo = quantityInfo;
-         }
-      }
-   }
-}
\ No newline at end of file
diff --git a/src/MoBi.Core/Serialization/Converter/v6_1/Converter60To61.cs b/src/MoBi.Core/Serialization/Converter/v6_1/Converter60To61.cs
index 773537a18..309045d3f 100644
--- a/src/MoBi.Core/Serialization/Converter/v6_1/Converter60To61.cs
+++ b/src/MoBi.Core/Serialization/Converter/v6_1/Converter60To61.cs
@@ -14,10 +14,10 @@ public class Converter60To61 : IMoBiObjectConverter,
       IVisitor<IBuildConfiguration>,
       IVisitor<IModelCoreSimulation>
    {
-      private readonly OSPSuite.Core.Converter.v6_1.Converter60To61 _coreConverter60To61;
+      private readonly OSPSuite.Core.Converters.v6_1.Converter60To61 _coreConverter60To61;
       private bool _converted;
 
-      public Converter60To61(OSPSuite.Core.Converter.v6_1.Converter60To61 coreConverter60To61)
+      public Converter60To61(OSPSuite.Core.Converters.v6_1.Converter60To61 coreConverter60To61)
       {
          _coreConverter60To61 = coreConverter60To61;
       }
diff --git a/src/MoBi.Core/Serialization/Converter/v6_2/Converter62To63.cs b/src/MoBi.Core/Serialization/Converter/v6_2/Converter62To63.cs
index 805c02951..7476af9c1 100644
--- a/src/MoBi.Core/Serialization/Converter/v6_2/Converter62To63.cs
+++ b/src/MoBi.Core/Serialization/Converter/v6_2/Converter62To63.cs
@@ -5,9 +5,9 @@ namespace MoBi.Core.Serialization.Converter.v6_2
 {
    public class Converter62To63 : IMoBiObjectConverter
    {
-      private readonly OSPSuite.Core.Converter.v6_3.Converter62To63 _coreConverter;
+      private readonly OSPSuite.Core.Converters.v6_3.Converter62To63 _coreConverter;
 
-      public Converter62To63(OSPSuite.Core.Converter.v6_3.Converter62To63 coreConverter)
+      public Converter62To63(OSPSuite.Core.Converters.v6_3.Converter62To63 coreConverter)
       {
          _coreConverter = coreConverter;
       }
diff --git a/src/MoBi.Core/Serialization/Converter/v7_1/Converter63To710.cs b/src/MoBi.Core/Serialization/Converter/v7_1/Converter63To710.cs
index 1b6fd8cea..002ac29c0 100644
--- a/src/MoBi.Core/Serialization/Converter/v7_1/Converter63To710.cs
+++ b/src/MoBi.Core/Serialization/Converter/v7_1/Converter63To710.cs
@@ -5,9 +5,9 @@ namespace MoBi.Core.Serialization.Converter.v7_1
 {
    public class Converter63To710 : IMoBiObjectConverter
    {
-      private readonly OSPSuite.Core.Converter.v7_1.Converter63To710 _coreConverter;
+      private readonly OSPSuite.Core.Converters.v7_1.Converter63To710 _coreConverter;
 
-      public Converter63To710(OSPSuite.Core.Converter.v7_1.Converter63To710 coreConverter)
+      public Converter63To710(OSPSuite.Core.Converters.v7_1.Converter63To710 coreConverter)
       {
          _coreConverter = coreConverter;
       }
diff --git a/src/MoBi.Core/Serialization/Converter/v7_3/Converter710To730.cs b/src/MoBi.Core/Serialization/Converter/v7_3/Converter710To730.cs
index a29f859be..5a5affd4d 100644
--- a/src/MoBi.Core/Serialization/Converter/v7_3/Converter710To730.cs
+++ b/src/MoBi.Core/Serialization/Converter/v7_3/Converter710To730.cs
@@ -5,9 +5,9 @@ namespace MoBi.Core.Serialization.Converter.v7_3
 {
    public class Converter710To730 : IMoBiObjectConverter
    {
-      private readonly OSPSuite.Core.Converter.v7_3.Converter710To730 _coreConverter;
+      private readonly OSPSuite.Core.Converters.v7_3.Converter710To730 _coreConverter;
 
-      public Converter710To730(OSPSuite.Core.Converter.v7_3.Converter710To730 coreConverter)
+      public Converter710To730(OSPSuite.Core.Converters.v7_3.Converter710To730 coreConverter)
       {
          _coreConverter = coreConverter;
       }
diff --git a/src/MoBi.Core/Serialization/Converter/v3_6/Converter351To361.cs b/src/MoBi.Core/Serialization/Converter/v9/Converter730To90.cs
similarity index 57%
rename from src/MoBi.Core/Serialization/Converter/v3_6/Converter351To361.cs
rename to src/MoBi.Core/Serialization/Converter/v9/Converter730To90.cs
index 7889264d5..1182c3160 100644
--- a/src/MoBi.Core/Serialization/Converter/v3_6/Converter351To361.cs
+++ b/src/MoBi.Core/Serialization/Converter/v9/Converter730To90.cs
@@ -1,22 +1,18 @@
 using System.Xml.Linq;
 using MoBi.Core.Domain.Model;
-using OSPSuite.Core.Converter.v5_6;
 
-namespace MoBi.Core.Serialization.Converter.v3_6
+namespace MoBi.Core.Serialization.Converter.v9
 {
-   public class Converter351To361 : IMoBiObjectConverter
+   public class Converter730To90 : IMoBiObjectConverter
    {
-      private readonly Converter551To561 _coreConverter;
+      private readonly OSPSuite.Core.Converters.v9.Converter730To90 _coreConverter;
 
-      public Converter351To361(Converter551To561 coreConverter)
+      public Converter730To90(OSPSuite.Core.Converters.v9.Converter730To90 coreConverter)
       {
          _coreConverter = coreConverter;
       }
 
-      public bool IsSatisfiedBy(int item)
-      {
-         return _coreConverter.IsSatisfiedBy(item);
-      }
+      public bool IsSatisfiedBy(int version) => version == ProjectVersions.V7_3_0;
 
       public (int convertedToVersion, bool conversionHappened) Convert(object objectToUpdate, IMoBiProject project)
       {
diff --git a/src/MoBi.Core/Serialization/ORM/ContextPersistor.cs b/src/MoBi.Core/Serialization/ORM/ContextPersistor.cs
index 7844f1cac..9f193a235 100644
--- a/src/MoBi.Core/Serialization/ORM/ContextPersistor.cs
+++ b/src/MoBi.Core/Serialization/ORM/ContextPersistor.cs
@@ -8,7 +8,7 @@
 using MoBi.Core.Services;
 using OSPSuite.Core.Journal;
 using OSPSuite.Infrastructure.Serialization.ORM.History;
-using OSPSuite.Infrastructure.Services;
+using OSPSuite.Infrastructure.Serialization.Services;
 using OSPSuite.Utility;
 using OSPSuite.Utility.Events;
 
diff --git a/src/MoBi.Core/Serialization/ORM/Mappers/ProjectToProjectMetaDataMapper.cs b/src/MoBi.Core/Serialization/ORM/Mappers/ProjectToProjectMetaDataMapper.cs
index a798eaf5b..e9454de48 100644
--- a/src/MoBi.Core/Serialization/ORM/Mappers/ProjectToProjectMetaDataMapper.cs
+++ b/src/MoBi.Core/Serialization/ORM/Mappers/ProjectToProjectMetaDataMapper.cs
@@ -1,6 +1,4 @@
 using System.Linq;
-using OSPSuite.Utility;
-using OSPSuite.Utility.Extensions;
 using MoBi.Core.Domain.Extensions;
 using MoBi.Core.Domain.Model;
 using MoBi.Core.Serialization.ORM.MetaData;
@@ -9,6 +7,8 @@
 using OSPSuite.Core.Domain;
 using OSPSuite.Core.Domain.Data;
 using OSPSuite.Infrastructure.Serialization.ORM.MetaData;
+using OSPSuite.Utility;
+using OSPSuite.Utility.Extensions;
 using DataRepositoryMetaData = MoBi.Core.Serialization.ORM.MetaData.DataRepositoryMetaData;
 
 namespace MoBi.Core.Serialization.ORM.Mappers
diff --git a/src/MoBi.Core/Serialization/ORM/ProjectPersistor.cs b/src/MoBi.Core/Serialization/ORM/ProjectPersistor.cs
index 07a041584..79238000f 100644
--- a/src/MoBi.Core/Serialization/ORM/ProjectPersistor.cs
+++ b/src/MoBi.Core/Serialization/ORM/ProjectPersistor.cs
@@ -3,7 +3,7 @@
 using MoBi.Core.Serialization.ORM.Mappers;
 using MoBi.Core.Serialization.ORM.MetaData;
 using MoBi.Core.Serialization.Services;
-using OSPSuite.Infrastructure.Services;
+using OSPSuite.Infrastructure.Serialization.Services;
 
 namespace MoBi.Core.Serialization.ORM
 {
diff --git a/src/MoBi.Core/Serialization/ORM/SessionFactoryProvider.cs b/src/MoBi.Core/Serialization/ORM/SessionFactoryProvider.cs
index 556de5551..f3cd5f9ae 100644
--- a/src/MoBi.Core/Serialization/ORM/SessionFactoryProvider.cs
+++ b/src/MoBi.Core/Serialization/ORM/SessionFactoryProvider.cs
@@ -3,7 +3,7 @@
 using NHibernate.Cfg;
 using NHibernate.Tool.hbm2ddl;
 using OSPSuite.Core.Extensions;
-using OSPSuite.Infrastructure.Services;
+using OSPSuite.Infrastructure.Serialization.Services;
 
 namespace MoBi.Core.Serialization.ORM
 {
diff --git a/src/MoBi.Core/Serialization/Services/PostSerializationStepsMaker.cs b/src/MoBi.Core/Serialization/Services/PostSerializationStepsMaker.cs
index 219d995b7..6c7718ebe 100644
--- a/src/MoBi.Core/Serialization/Services/PostSerializationStepsMaker.cs
+++ b/src/MoBi.Core/Serialization/Services/PostSerializationStepsMaker.cs
@@ -1,9 +1,9 @@
 using System.Collections.Generic;
-using OSPSuite.Utility.Extensions;
 using MoBi.Core.Domain.Model;
 using MoBi.Core.Services;
 using OSPSuite.Core.Domain.Services;
 using OSPSuite.Core.Serialization;
+using OSPSuite.Utility.Extensions;
 
 namespace MoBi.Core.Serialization.Services
 {
@@ -18,33 +18,26 @@ public class PostSerializationStepsMaker : IPostSerializationStepsMaker
    {
       private readonly IObjectIdResetter _objectIdResetter;
       private readonly IAmountToConcentrationConverter _amountToConcentrationConverter;
-      private readonly IPassiveTransportConverter _passiveTransportConverter;
       private readonly IProjectClassifiableUpdaterAfterDeserialization _projectClassifiableUpdaterAfterDeserialization;
       private readonly IProjectClassificationConverter _projectClassificationConverter;
 
       public PostSerializationStepsMaker(IObjectIdResetter objectIdResetter,
          IAmountToConcentrationConverter amountToConcentrationConverter,
-         IPassiveTransportConverter passiveTransportConverter, 
          IProjectClassifiableUpdaterAfterDeserialization projectClassifiableUpdaterAfterDeserialization,
          IProjectClassificationConverter projectClassificationConverter)
       {
          _objectIdResetter = objectIdResetter;
          _amountToConcentrationConverter = amountToConcentrationConverter;
-         _passiveTransportConverter = passiveTransportConverter;
          _projectClassifiableUpdaterAfterDeserialization = projectClassifiableUpdaterAfterDeserialization;
          _projectClassificationConverter = projectClassificationConverter;
       }
 
       public void PerformPostDeserializationFor(IMoBiProject project, int originalFileVersion)
       {
-         if (originalFileVersion < ProjectVersions.V3_5_1)
-            _passiveTransportConverter.Convert(project);
-
-
          if (originalFileVersion < ProjectVersions.V6_0_1)
             //this needs to be done after all object were loaded into project
             _projectClassificationConverter.Convert(project);
-            
+
          //this needs to be done once the project was loaded into context
          _projectClassifiableUpdaterAfterDeserialization.Update(project);
       }
@@ -56,11 +49,6 @@ public void PerformPostDeserializationFor<T>(IReadOnlyList<T> deserializedObject
 
          //Convert loaded object to concentration if required
          deserializedObjects.Each(o => _amountToConcentrationConverter.Convert(o));
-
-         //Move passive transports defined in moelcules in the passive transport building block. This needs to be done after the deserialization
-         //step as we might need to add new buildging block to project. Required only for project older than 3.5
-         if (originalFileVersion < ProjectVersions.V3_5_1)
-            deserializedObjects.Each(o => _passiveTransportConverter.Convert(o));
       }
    }
 }
\ No newline at end of file
diff --git a/src/MoBi.Core/Serialization/Services/SerializationContextFactory.cs b/src/MoBi.Core/Serialization/Services/SerializationContextFactory.cs
index 117c03a62..1e0328245 100644
--- a/src/MoBi.Core/Serialization/Services/SerializationContextFactory.cs
+++ b/src/MoBi.Core/Serialization/Services/SerializationContextFactory.cs
@@ -1,10 +1,10 @@
 using System.Collections.Generic;
 using System.Linq;
 using MoBi.Core.Services;
-using OSPSuite.Core.Converter.v5_2;
 using OSPSuite.Core.Domain;
 using OSPSuite.Core.Domain.Data;
 using OSPSuite.Core.Domain.Services;
+using OSPSuite.Core.Domain.UnitSystem;
 using OSPSuite.Core.Serialization.Xml;
 using OSPSuite.Utility.Extensions;
 using IContainer = OSPSuite.Utility.Container.IContainer;
@@ -18,13 +18,13 @@ public interface ISerializationContextFactory
 
    public class SerializationContextFactory : ISerializationContextFactory
    {
-      private readonly ISerializationDimensionFactory _dimensionFactory;
+      private readonly IDimensionFactory _dimensionFactory;
       private readonly IObjectBaseFactory _objectBaseFactory;
       private readonly ICloneManagerForModel _cloneManagerForModel;
       private readonly IContainer _container;
 
       public SerializationContextFactory(
-         ISerializationDimensionFactory dimensionFactory,
+         IDimensionFactory dimensionFactory,
          IObjectBaseFactory objectBaseFactory,
          ICloneManagerForModel cloneManagerForModel,
          IContainer container
diff --git a/src/MoBi.Core/Serialization/Xml/Serializer/MergedDimensionFactorySerializer.cs b/src/MoBi.Core/Serialization/Xml/Serializer/MergedDimensionFactorySerializer.cs
deleted file mode 100644
index 2caecfcfc..000000000
--- a/src/MoBi.Core/Serialization/Xml/Serializer/MergedDimensionFactorySerializer.cs
+++ /dev/null
@@ -1,40 +0,0 @@
-using System.Xml.Linq;
-using OSPSuite.Serializer.Xml;
-using OSPSuite.Utility.Container;
-using MoBi.Core.Domain.UnitSystem;
-using OSPSuite.Core.Domain.UnitSystem;
-using OSPSuite.Core.Serialization.Xml;
-
-namespace MoBi.Core.Serialization.Xml.Serializer
-{
-   public class MergedDimensionFactorySerializer : OSPSuiteXmlSerializer<DimensionFactory>
-   {
-      private readonly IXmlSerializer<SerializationContext> _serializer;
-
-      public MergedDimensionFactorySerializer()
-      {
-         var unitSystemRepositoty = IoC.Resolve<IUnitSystemXmlSerializerRepository>();
-         _serializer = unitSystemRepositoty.SerializerFor<IDimensionFactory>();
-      }
-
-      public override DimensionFactory CreateObject(XElement element, SerializationContext serializationContext)
-      {
-         return new MoBiMergedDimensionFactory();
-      }
-
-      public override void PerformMapping()
-      {
-         //nothing to do here as the serialization action will be performed in the overload
-      }
-
-      protected override XElement TypedSerialize(DimensionFactory objectToSerialize, SerializationContext serializationContext)
-      {
-         return _serializer.Serialize(objectToSerialize, serializationContext);
-      }
-
-      protected override void TypedDeserialize(DimensionFactory objectToDeserialize, XElement outputToDeserialize, SerializationContext serializationContext)
-      {
-         _serializer.Deserialize(objectToDeserialize, outputToDeserialize, serializationContext);
-      }
-   }
-}
\ No newline at end of file
diff --git a/src/MoBi.Core/Serialization/Xml/Serializer/MoBiProjectXmlSerializer.cs b/src/MoBi.Core/Serialization/Xml/Serializer/MoBiProjectXmlSerializer.cs
index a19ee4250..ea9cae162 100644
--- a/src/MoBi.Core/Serialization/Xml/Serializer/MoBiProjectXmlSerializer.cs
+++ b/src/MoBi.Core/Serialization/Xml/Serializer/MoBiProjectXmlSerializer.cs
@@ -10,18 +10,10 @@ public class MoBiProjectXmlSerializer : ProjectXmlSerializer<MoBiProject>
       public override void PerformMapping()
       {
          base.PerformMapping();
-         Map(x => x.DimensionFactory);
          Map(x => x.ReactionDimensionMode);
          MapEnumerable(x => x.AllObservedData, x => x.AddObservedData);
       }
 
-      protected override void TypedDeserialize(MoBiProject project, XElement outputToDeserialize, SerializationContext serializationContext)
-      {
-         base.TypedDeserialize(project, outputToDeserialize,serializationContext);
-         var dimFactory = IoC.Resolve<IMoBiContext>().DimensionFactory;
-         dimFactory.ProjectFactory = project.DimensionFactory;
-      }
-
       public override MoBiProject CreateObject(XElement element, SerializationContext serializationContext)
       {
          return IoC.Resolve<IMoBiProject>() as MoBiProject;
diff --git a/src/MoBi.Core/Serialization/Xml/Services/XmlSerializationService.cs b/src/MoBi.Core/Serialization/Xml/Services/XmlSerializationService.cs
index 0bc836f42..c53ad7aec 100644
--- a/src/MoBi.Core/Serialization/Xml/Services/XmlSerializationService.cs
+++ b/src/MoBi.Core/Serialization/Xml/Services/XmlSerializationService.cs
@@ -206,7 +206,7 @@ public int VersionFrom(XElement element)
       {
          string versionString = element.GetAttribute(Constants.Serialization.Attribute.VERSION);
          if (string.IsNullOrEmpty(versionString))
-            return ProjectVersions.V3_0_1_to_3;
+            return ProjectVersions.UNSUPPORTED;
 
          return versionString.ConvertedTo<int>();
       }
diff --git a/src/MoBi.Core/Services/AmountToConcentrationConverter.cs b/src/MoBi.Core/Services/AmountToConcentrationConverter.cs
index 1b8837c63..8251dc14c 100644
--- a/src/MoBi.Core/Services/AmountToConcentrationConverter.cs
+++ b/src/MoBi.Core/Services/AmountToConcentrationConverter.cs
@@ -182,12 +182,12 @@ public void Convert(object objectToConvert)
 
       private bool conversionRequired(IMoleculeStartValue moleculeStartValue)
       {
-         return conversionRequired(moleculeStartValue, Constants.Dimension.AMOUNT);
+         return conversionRequired(moleculeStartValue, Constants.Dimension.MOLAR_AMOUNT);
       }
 
       private bool conversionRequired(IMoleculeBuilder moleculeBuilder)
       {
-         return conversionRequired(moleculeBuilder, Constants.Dimension.AMOUNT);
+         return conversionRequired(moleculeBuilder, Constants.Dimension.MOLAR_AMOUNT);
       }
 
       private bool conversionRequired(IReactionBuilder reaction)
diff --git a/src/MoBi.Core/Services/ModelPartsToExcelExporterTask.cs b/src/MoBi.Core/Services/ModelPartsToExcelExporterTask.cs
index 11b4452ca..ceab45b27 100644
--- a/src/MoBi.Core/Services/ModelPartsToExcelExporterTask.cs
+++ b/src/MoBi.Core/Services/ModelPartsToExcelExporterTask.cs
@@ -4,19 +4,19 @@
 using MoBi.Core.Domain.Model;
 using MoBi.Core.Mappers;
 using OSPSuite.Core.Domain;
-using OSPSuite.Infrastructure.Services;
+using OSPSuite.Infrastructure.Export;
 
 namespace MoBi.Core.Services
 {
    public interface IModelPartsToExcelExporterTask
    {
       /// <summary>
-      /// Export parts of a simulation model to an Excel file
+      ///    Export parts of a simulation model to an Excel file
       /// </summary>
       /// <param name="excelFileName">The name of the excel file</param>
       /// <param name="simulation">The simulation that is being exported</param>
       /// <param name="openExcel">true if an an attempt to open excel should be made after export</param>
-      void ExportModelPartsToExcelFile (string excelFileName, IMoBiSimulation simulation, bool openExcel);
+      void ExportModelPartsToExcelFile(string excelFileName, IMoBiSimulation simulation, bool openExcel);
    }
 
    public class ModelPartsToExcelExporterTask : IModelPartsToExcelExporterTask
@@ -51,4 +51,4 @@ public void ExportModelPartsToExcelFile(string excelFileName, IMoBiSimulation si
          });
       }
    }
-}
+}
\ No newline at end of file
diff --git a/src/MoBi.Core/Services/PassiveTransportConverter.cs b/src/MoBi.Core/Services/PassiveTransportConverter.cs
deleted file mode 100644
index 998cd93f0..000000000
--- a/src/MoBi.Core/Services/PassiveTransportConverter.cs
+++ /dev/null
@@ -1,166 +0,0 @@
-using System.Collections.Generic;
-using System.Linq;
-using MoBi.Assets;
-using OSPSuite.Utility.Events;
-using OSPSuite.Utility.Extensions;
-using OSPSuite.Utility.Visitor;
-using MoBi.Core.Domain.Model;
-using MoBi.Core.Events;
-using OSPSuite.Core.Domain;
-using OSPSuite.Core.Domain.Builder;
-using OSPSuite.Core.Domain.Services;
-using OSPSuite.Core.Serialization.Exchange;
-using OSPSuite.Assets;
-
-namespace MoBi.Core.Services
-{
-   public interface IPassiveTransportConverter
-   {
-      void Convert(object objectToConvert);
-   }
-
-   public class PassiveTransportConverter : IPassiveTransportConverter, IVisitor<IMoleculeBuildingBlock>, IVisitor<IMoleculeBuilder>, IVisitor<IBuildConfiguration>, IVisitor<SimulationTransfer>, IVisitor<IModelCoreSimulation>, IVisitor<IMoBiProject>
-
-   {
-      private readonly IObjectBaseFactory _objectBaseFactory;
-      private readonly IMoBiProjectRetriever _projectRetriever;
-      private readonly IContainerTask _containerTask;
-      private readonly IEventPublisher _eventPublisher;
-      private readonly ICloneManagerForModel _cloneManager;
-      private readonly IFormulaTask _formulaTask;
-
-      public PassiveTransportConverter(IObjectBaseFactory objectBaseFactory, IMoBiProjectRetriever projectRetriever, IContainerTask containerTask,
-         IEventPublisher eventPublisher, ICloneManagerForModel cloneManager, IFormulaTask formulaTask)
-      {
-         _objectBaseFactory = objectBaseFactory;
-         _projectRetriever = projectRetriever;
-         _containerTask = containerTask;
-         _eventPublisher = eventPublisher;
-         _cloneManager = cloneManager;
-         _formulaTask = formulaTask;
-      }
-
-      public void Convert(object objectToConvert)
-      {
-         this.Visit(objectToConvert);
-      }
-
-      public void Visit(IMoleculeBuildingBlock moleculeBuildingBlock)
-      {
-         var passiveTransportBuildingBlock = createPassiveTransportBuildingBlockForMolecule(moleculeBuildingBlock.Name);
-         convert(moleculeBuildingBlock, passiveTransportBuildingBlock);
-         addPassiveTransportToProject(passiveTransportBuildingBlock);
-      }
-
-      private void convert(IMoleculeBuildingBlock moleculeBuildingBlock, IPassiveTransportBuildingBlock passiveTransportBuildingBlock)
-      {
-         convert(moleculeBuildingBlock, new[] {passiveTransportBuildingBlock});
-      }
-
-      private void convert(IMoleculeBuildingBlock moleculeBuildingBlock, IReadOnlyList<IPassiveTransportBuildingBlock> passiveTransportBuildingBlocks)
-      {
-         moleculeBuildingBlock.Each(m => convert(m, moleculeBuildingBlock, passiveTransportBuildingBlocks));
-      }
-
-      private IPassiveTransportBuildingBlock createPassiveTransportBuildingBlockForMolecule(string name)
-      {
-         return _objectBaseFactory.Create<IPassiveTransportBuildingBlock>()
-            .WithName(_containerTask.CreateUniqueName(_projectRetriever.Current.PassiveTransportCollection, name, canUseBaseName: true));
-      }
-
-      public void Visit(IMoleculeBuilder moleculeBuilder)
-      {
-         var passiveTransportBuildingBlock = createPassiveTransportBuildingBlockForMolecule(moleculeBuilder.Name);
-         convert(moleculeBuilder, null, passiveTransportBuildingBlock);
-         addPassiveTransportToProject(passiveTransportBuildingBlock);
-      }
-
-      private void convert(IMoleculeBuilder moleculeBuilder, IMoleculeBuildingBlock moleculeBuildingBlock, IPassiveTransportBuildingBlock passiveTransportBuildingBlock)
-      {
-         convert(moleculeBuilder, moleculeBuildingBlock, new[] {passiveTransportBuildingBlock});
-      }
-
-      private void convert(IMoleculeBuilder moleculeBuilder, IMoleculeBuildingBlock moleculeBuildingBlock, IReadOnlyList<IPassiveTransportBuildingBlock> passiveTransportBuildingBlocks)
-      {
-         var allPassiveTransports = moleculeBuilder.GetChildren<ITransportBuilder>().ToList();
-         if (!allPassiveTransports.Any()) return;
-
-         foreach (var passiveTransport in allPassiveTransports)
-         {
-            moleculeBuilder.RemoveChild(passiveTransport);
-            var defaultName = AppConstants.CompositeNameFor(passiveTransport.Name, moleculeBuilder.Name);
-
-            foreach (var passiveTransportBuildingBlock in passiveTransportBuildingBlocks)
-            {
-               if (similarPassiveTransportAlreadyExists(passiveTransportBuildingBlock, passiveTransport, defaultName))
-               {
-                  var existingPassiveTransport = passiveTransportBuildingBlock.FindByName(defaultName);
-                  existingPassiveTransport.AddMoleculeName(moleculeBuilder.Name);
-                  continue;
-               }
-
-               var passiveTransportClone = _cloneManager.Clone(passiveTransport);
-               passiveTransportClone.Name = _containerTask.CreateUniqueName(passiveTransportBuildingBlock, defaultName, canUseBaseName: true);
-               passiveTransportClone.ForAll = false;
-               passiveTransportClone.AddMoleculeName(moleculeBuilder.Name);
-               passiveTransportClone.Parameters.Each(x => x.BuildMode = ParameterBuildMode.Local);
-               passiveTransportBuildingBlock.Add(passiveTransportClone);
-               passiveTransportBuildingBlock.AddFormula(passiveTransportClone.Formula);
-            }
-
-            if (moleculeBuildingBlock != null)
-               moleculeBuildingBlock.FormulaCache.Remove(passiveTransport.Formula);
-         }
-      }
-
-      private bool similarPassiveTransportAlreadyExists(IPassiveTransportBuildingBlock passiveTransportBuildingBlock, ITransportBuilder passiveTransport, string passiveTransportName)
-      {
-         var existingPassiveTransport = passiveTransportBuildingBlock.FindByName(passiveTransportName);
-         if (existingPassiveTransport == null) return false;
-
-         return _formulaTask.FormulasAreTheSame(existingPassiveTransport.Formula, passiveTransport.Formula);
-      }
-
-      private void convert(IMoBiProject project)
-      {
-         //we should only convert the template building blocks by creating the cartesian product of all 
-         foreach (var moleculeBuildingBlock in project.MoleculeBlockCollection)
-         {
-            convert(moleculeBuildingBlock, project.PassiveTransportCollection);
-         }
-      }
-
-      private void addPassiveTransportToProject(IPassiveTransportBuildingBlock passiveTransportBuildingBlock)
-      {
-         _projectRetriever.Current.AddBuildingBlock(passiveTransportBuildingBlock);
-         var notification = new NotificationMessage(passiveTransportBuildingBlock, MessageOrigin.Simulation, passiveTransportBuildingBlock, NotificationType.Info)
-         {
-            Message = AppConstants.Warnings.PassiveTransportBuildingBlockCreatedAutomatically(passiveTransportBuildingBlock.Name),
-            ObjectType = ObjectTypes.PassiveTransportBuildingBlock,
-            BuildingBlockType = ObjectTypes.PassiveTransportBuildingBlock,
-         };
-         _eventPublisher.PublishEvent(new ShowNotificationsEvent(notification));
-      }
-
-      public void Visit(IBuildConfiguration buildConfiguration)
-      {
-         convert(buildConfiguration.Molecules, buildConfiguration.PassiveTransports);
-      }
-
-      public void Visit(SimulationTransfer simulationTransfer)
-      {
-         Visit(simulationTransfer.Simulation);
-      }
-
-      public void Visit(IModelCoreSimulation simulation)
-      {
-         Visit(simulation.BuildConfiguration);
-      }
-
-      public void Visit(IMoBiProject project)
-      {
-         convert(project);
-         project.Simulations.Each(Visit);
-      }
-   }
-}
\ No newline at end of file
diff --git a/src/MoBi.Core/Services/ReactionDimensionRetriever.cs b/src/MoBi.Core/Services/ReactionDimensionRetriever.cs
index 5df399b0b..7e2c5c3bb 100644
--- a/src/MoBi.Core/Services/ReactionDimensionRetriever.cs
+++ b/src/MoBi.Core/Services/ReactionDimensionRetriever.cs
@@ -17,7 +17,7 @@ public ReactionDimensionRetriever(IDimensionFactory dimensionFactory, IMoBiProje
 
       public IDimension ReactionDimension => getDimension(Constants.Dimension.AMOUNT_PER_TIME, Constants.Dimension.MOLAR_CONCENTRATION_PER_TIME);
 
-      public IDimension MoleculeDimension => getDimension(Constants.Dimension.AMOUNT, Constants.Dimension.MOLAR_CONCENTRATION);
+      public IDimension MoleculeDimension => getDimension(Constants.Dimension.MOLAR_AMOUNT, Constants.Dimension.MOLAR_CONCENTRATION);
 
       public ReactionDimensionMode SelectedDimensionMode => _projectRetriever.Current?.ReactionDimensionMode ?? ReactionDimensionMode.AmountBased;
 
diff --git a/src/MoBi.Engine/Tasks/SimModelManagerFactory.cs b/src/MoBi.Core/Services/SimModelManagerFactory.cs
similarity index 70%
rename from src/MoBi.Engine/Tasks/SimModelManagerFactory.cs
rename to src/MoBi.Core/Services/SimModelManagerFactory.cs
index cc6d7a637..e0c1a712c 100644
--- a/src/MoBi.Engine/Tasks/SimModelManagerFactory.cs
+++ b/src/MoBi.Core/Services/SimModelManagerFactory.cs
@@ -1,27 +1,29 @@
 using MoBi.Core.Domain.Model;
-using MoBi.Presentation.Tasks;
+using OSPSuite.Core.Domain;
 using OSPSuite.Core.Domain.Services;
 using OSPSuite.Core.Serialization.SimModel.Services;
 using OSPSuite.Core.Services;
-using OSPSuite.Engine.Domain;
 
-namespace MoBi.Engine.Tasks
+namespace MoBi.Core.Services
 {
+   public interface ISimModelManagerFactory
+   {
+      ISimModelManager Create();
+   }
+
    public class SimModelManagerFactory : ISimModelManagerFactory
    {
       private readonly ISimModelExporter _simModelExporter;
       private readonly ISimModelSimulationFactory _simModelSimulationFactory;
       private readonly IMoBiContext _context;
-      private readonly IDataNamingService _dataNamingService;
       private readonly IDisplayUnitRetriever _displayUnitRetriever;
       private readonly IDataRepositoryTask _dataRepositoryTask;
 
-      public SimModelManagerFactory(ISimModelExporter simModelExporter, ISimModelSimulationFactory simModelSimulationFactory, IMoBiContext context, IDataNamingService dataNamingService, IDisplayUnitRetriever displayUnitRetriever, IDataRepositoryTask dataRepositoryTask)
+      public SimModelManagerFactory(ISimModelExporter simModelExporter, ISimModelSimulationFactory simModelSimulationFactory, IMoBiContext context,  IDisplayUnitRetriever displayUnitRetriever, IDataRepositoryTask dataRepositoryTask)
       {
          _simModelExporter = simModelExporter;
          _simModelSimulationFactory = simModelSimulationFactory;
          _context = context;
-         _dataNamingService = dataNamingService;
          _displayUnitRetriever = displayUnitRetriever;
          _dataRepositoryTask = dataRepositoryTask;
       }
@@ -33,7 +35,7 @@ public ISimModelManager Create()
 
       private DataFactory createDataFactory()
       {
-         return new DataFactory(_context.DimensionFactory, _dataNamingService, _context.ObjectPathFactory, _displayUnitRetriever, _dataRepositoryTask);
+         return new DataFactory(_context.DimensionFactory, _context.ObjectPathFactory, _displayUnitRetriever, _dataRepositoryTask);
       }
    }
 }
\ No newline at end of file
diff --git a/src/MoBi.Core/app.config b/src/MoBi.Core/app.config
deleted file mode 100644
index 7824742fd..000000000
--- a/src/MoBi.Core/app.config
+++ /dev/null
@@ -1,75 +0,0 @@
-<?xml version="1.0" encoding="utf-8"?>
-<configuration>
-  <runtime>
-    <assemblyBinding xmlns="urn:schemas-microsoft-com:asm.v1">
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.Utils.v18.2" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.XtraTreeList.v18.2" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.XtraEditors.v18.2" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.XtraGrid.v18.2" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.XtraLayout.v18.2" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.XtraBars.v18.2" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.Data.v18.2" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.XtraCharts.v18.2.UI" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.XtraCharts.v18.2" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="MPFitLib" publicKeyToken="be1b3c0b5819660a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-1.1.0.0" newVersion="1.1.0.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="Northwoods.Go" publicKeyToken="a4e3b7b70161cfe8" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-4.1.0.2" newVersion="4.1.0.2" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="Northwoods.Go.Xml" publicKeyToken="a4e3b7b70161cfe8" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-4.1.0.2" newVersion="4.1.0.2" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="NHibernate" publicKeyToken="aa95f207798dfdb4" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-5.2.0.0" newVersion="5.2.0.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="SX" publicKeyToken="882b9c044052e7f6" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-2.7.0.9" newVersion="2.7.0.9" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="System.Data.SQLite" publicKeyToken="db937bc2d44ff139" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-1.0.110.0" newVersion="1.0.110.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="Iesi.Collections" publicKeyToken="aa95f207798dfdb4" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-4.0.0.4000" newVersion="4.0.0.4000" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="Newtonsoft.Json" publicKeyToken="30ad4fe6b2a6aeed" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-10.0.0.0" newVersion="10.0.0.0" />
-      </dependentAssembly>
-    </assemblyBinding>
-  </runtime>
-<startup><supportedRuntime version="v4.0" sku=".NETFramework,Version=v4.6.2" /></startup></configuration>
diff --git a/src/MoBi.Core/packages.config b/src/MoBi.Core/packages.config
deleted file mode 100644
index 50d0d87f3..000000000
--- a/src/MoBi.Core/packages.config
+++ /dev/null
@@ -1,40 +0,0 @@
-<?xml version="1.0" encoding="utf-8"?>
-<packages>
-  <package id="Antlr3.Runtime" version="3.5.1" targetFramework="net462" />
-  <package id="Castle.Core" version="4.3.1" targetFramework="net462" />
-  <package id="Castle.Windsor" version="4.1.1" targetFramework="net462" />
-  <package id="csmpfit" version="1.1.1" targetFramework="net462" />
-  <package id="Dapper" version="1.60.6" targetFramework="net462" />
-  <package id="FluentNHibernate" version="2.1.2" targetFramework="net462" />
-  <package id="Iesi.Collections" version="4.0.4" targetFramework="net462" />
-  <package id="MathNet.Numerics" version="4.7.0" targetFramework="net462" />
-  <package id="Microsoft.Extensions.Configuration" version="2.2.0" targetFramework="net462" />
-  <package id="Microsoft.Extensions.Configuration.Abstractions" version="2.2.0" targetFramework="net462" />
-  <package id="Microsoft.Extensions.Configuration.Binder" version="2.2.0" targetFramework="net462" />
-  <package id="Microsoft.Extensions.DependencyInjection.Abstractions" version="2.2.0" targetFramework="net462" />
-  <package id="Microsoft.Extensions.Logging" version="2.2.0" targetFramework="net462" />
-  <package id="Microsoft.Extensions.Logging.Abstractions" version="2.2.0" targetFramework="net462" />
-  <package id="Microsoft.Extensions.Options" version="2.2.0" targetFramework="net462" />
-  <package id="Microsoft.Extensions.Primitives" version="2.2.0" targetFramework="net462" />
-  <package id="Newtonsoft.Json" version="12.0.1" targetFramework="net462" />
-  <package id="NHibernate" version="5.2.5" targetFramework="net462" />
-  <package id="OSPSuite.Assets" version="8.0.4" targetFramework="net462" />
-  <package id="OSPSuite.Core" version="8.0.4" targetFramework="net462" />
-  <package id="OSPSuite.DevExpress.Presentation" version="18.2.7" targetFramework="net462" />
-  <package id="OSPSuite.Infrastructure" version="8.0.4" targetFramework="net462" />
-  <package id="OSPSuite.Presentation" version="8.0.4" targetFramework="net462" />
-  <package id="OSPSuite.Serializer" version="2.0.1.4" targetFramework="net462" />
-  <package id="OSPSuite.SmartXLS" version="2.7.0.9" targetFramework="net462" />
-  <package id="OSPSuite.TeXReporting" version="2.1.1.9" targetFramework="net462" />
-  <package id="OSPSuite.Utility" version="3.0.1.7" targetFramework="net462" />
-  <package id="Remotion.Linq" version="2.2.0" targetFramework="net462" />
-  <package id="Remotion.Linq.EagerFetching" version="2.2.0" targetFramework="net462" />
-  <package id="SharpZipLib" version="1.1.0" targetFramework="net462" />
-  <package id="System.Buffers" version="4.4.0" targetFramework="net462" />
-  <package id="System.ComponentModel.Annotations" version="4.5.0" targetFramework="net462" />
-  <package id="System.Data.SQLite.Core" version="1.0.110.0" targetFramework="net462" />
-  <package id="System.Memory" version="4.5.1" targetFramework="net462" />
-  <package id="System.Numerics.Vectors" version="4.4.0" targetFramework="net462" />
-  <package id="System.Runtime.CompilerServices.Unsafe" version="4.5.1" targetFramework="net462" />
-  <package id="System.ValueTuple" version="4.4.0" targetFramework="net462" />
-</packages>
\ No newline at end of file
diff --git a/src/MoBi.Engine/EngineRegister.cs b/src/MoBi.Engine/EngineRegister.cs
index dbb825826..3a069a3c2 100644
--- a/src/MoBi.Engine/EngineRegister.cs
+++ b/src/MoBi.Engine/EngineRegister.cs
@@ -1,9 +1,6 @@
-using MoBi.Core;
-using MoBi.Engine.Sbml;
+using MoBi.Engine.Sbml;
 using OSPSuite.Core;
-using OSPSuite.FuncParser;
 using OSPSuite.Utility.Container;
-using SimModelNET;
 
 namespace MoBi.Engine
 {
@@ -11,11 +8,6 @@ public class EngineRegister : Register
    {
       public override void RegisterInContainer(IContainer container)
       {
-         container.AddRegister(x => x.FromType<OSPSuite.Engine.EngineRegister>());
-         var pkSimConfiguration = container.Resolve<IMoBiConfiguration>();
-         XMLSchemaCache.InitializeFromFile(pkSimConfiguration.SimModelSchemaFilePath);
-
-         container.Register<IDimensionParser, DimensionParser>();
 
          container.AddRegister(x => x.FromType<SBMLImportRegister>());
 
diff --git a/src/MoBi.Engine/Extensions/DimensionInfoExtensions.cs b/src/MoBi.Engine/Extensions/DimensionInfoExtensions.cs
deleted file mode 100644
index 149a4e228..000000000
--- a/src/MoBi.Engine/Extensions/DimensionInfoExtensions.cs
+++ /dev/null
@@ -1,19 +0,0 @@
-using OSPSuite.FuncParser;
-
-namespace MoBi.Engine.Extensions
-{
-
-   public static class DimensionInfoExtensions
-   {
-      public static bool AreEquals(this IDimensionInfo left, IDimensionInfo right)
-      {
-         return (left.Length == right.Length
-                 && left.Mass == right.Mass
-                 && left.Time == right.Time
-                 && left.ElectricCurrent == right.ElectricCurrent
-                 && left.Temperature == right.Temperature
-                 && left.Amount == right.Amount
-                 && left.LuminousIntensity == right.LuminousIntensity);
-      }
-   }
-}
\ No newline at end of file
diff --git a/src/MoBi.Engine/MoBi.Engine.csproj b/src/MoBi.Engine/MoBi.Engine.csproj
index 8d36cdf23..ec6c16c4b 100644
--- a/src/MoBi.Engine/MoBi.Engine.csproj
+++ b/src/MoBi.Engine/MoBi.Engine.csproj
@@ -1,149 +1,58 @@
-<?xml version="1.0" encoding="utf-8"?>
-<Project ToolsVersion="15.0" xmlns="http://schemas.microsoft.com/developer/msbuild/2003">
-  <Import Project="$(MSBuildExtensionsPath)\$(MSBuildToolsVersion)\Microsoft.Common.props" Condition="Exists('$(MSBuildExtensionsPath)\$(MSBuildToolsVersion)\Microsoft.Common.props')" />
+<Project Sdk="Microsoft.NET.Sdk">
+
   <PropertyGroup>
-    <Configuration Condition=" '$(Configuration)' == '' ">Debug</Configuration>
-    <Platform Condition=" '$(Platform)' == '' ">AnyCPU</Platform>
-    <ProjectGuid>{15ED932C-EDEC-407B-91D9-7BCB8E7F95F5}</ProjectGuid>
-    <OutputType>Library</OutputType>
-    <AppDesignerFolder>Properties</AppDesignerFolder>
-    <RootNamespace>MoBi.Engine</RootNamespace>
-    <AssemblyName>MoBi.Engine</AssemblyName>
-    <TargetFrameworkVersion>v4.6.2</TargetFrameworkVersion>
-    <FileAlignment>512</FileAlignment>
-    <Deterministic>true</Deterministic>
+    <TargetFramework>net472</TargetFramework>
+    <Version>9.0.0</Version>
+    <PackageVersion>9.0.0</PackageVersion>
+    <AssemblyVersion>9.0.0</AssemblyVersion>
+    <FileVersion>9.0.0</FileVersion>
+    <InformationalVersion>9.0.0</InformationalVersion>
+    <GenerateAssemblyProductAttribute>false</GenerateAssemblyProductAttribute>
+    <GenerateAssemblyCompanyAttribute>false</GenerateAssemblyCompanyAttribute>
+    <PackageTags>open-systems-pharmacology, ospsuite-components</PackageTags>
+    <Description>Core functionalities for PK-Sim</Description>
+    <Authors>Open-Systems-Pharmacology</Authors>
+    <PackageLicenseFile>LICENSE</PackageLicenseFile>
+    <OutputPath>bin\$(Configuration)</OutputPath>
+    <DocumentationFile>bin\$(Configuration)\$(TargetFramework)\PKSim.Core.xml</DocumentationFile>
+    <NoWarn>1591</NoWarn>
+
   </PropertyGroup>
-  <PropertyGroup Condition=" '$(Configuration)|$(Platform)' == 'Debug|AnyCPU' ">
-    <DebugSymbols>true</DebugSymbols>
-    <DebugType>full</DebugType>
-    <Optimize>false</Optimize>
-    <OutputPath>bin\Debug\</OutputPath>
-    <DefineConstants>DEBUG;TRACE</DefineConstants>
-    <ErrorReport>prompt</ErrorReport>
-    <WarningLevel>4</WarningLevel>
-    <AllowUnsafeBlocks>false</AllowUnsafeBlocks>
+
+  <PropertyGroup Condition="'$(Configuration)|$(Platform)'=='Debug|AnyCPU'">
     <PlatformTarget>x64</PlatformTarget>
   </PropertyGroup>
-  <PropertyGroup Condition=" '$(Configuration)|$(Platform)' == 'Release|AnyCPU' ">
-    <DebugType>pdbonly</DebugType>
-    <Optimize>true</Optimize>
-    <OutputPath>bin\Release\</OutputPath>
-    <DefineConstants>TRACE</DefineConstants>
-    <ErrorReport>prompt</ErrorReport>
-    <WarningLevel>4</WarningLevel>
-  </PropertyGroup>
+
   <ItemGroup>
-    <Reference Include="DevExpress.Data.v18.2, Version=18.2.7.0, Culture=neutral, PublicKeyToken=b88d1754d700e49a, processorArchitecture=MSIL">
-      <HintPath>..\..\packages\OSPSuite.DevExpress.Presentation.18.2.7\lib\net45\DevExpress.Data.v18.2.dll</HintPath>
-    </Reference>
-    <Reference Include="DevExpress.Utils.v18.2, Version=18.2.7.0, Culture=neutral, PublicKeyToken=b88d1754d700e49a, processorArchitecture=MSIL">
-      <HintPath>..\..\packages\OSPSuite.DevExpress.Presentation.18.2.7\lib\net45\DevExpress.Utils.v18.2.dll</HintPath>
-    </Reference>
-    <Reference Include="libsbmlcsP, Version=5.11.4.0, Culture=neutral, processorArchitecture=AMD64">
-      <SpecificVersion>False</SpecificVersion>
-      <HintPath>..\..\pre\libsbmlcsP.dll</HintPath>
-    </Reference>
-    <Reference Include="MathNet.Numerics, Version=4.7.0.0, Culture=neutral, processorArchitecture=MSIL">
-      <HintPath>..\..\packages\MathNet.Numerics.4.7.0\lib\net461\MathNet.Numerics.dll</HintPath>
-    </Reference>
-    <Reference Include="Microsoft.Extensions.Logging.Abstractions, Version=2.2.0.0, Culture=neutral, PublicKeyToken=adb9793829ddae60, processorArchitecture=MSIL">
-      <HintPath>..\..\packages\Microsoft.Extensions.Logging.Abstractions.2.2.0\lib\netstandard2.0\Microsoft.Extensions.Logging.Abstractions.dll</HintPath>
-    </Reference>
-    <Reference Include="MPFitLib, Version=1.1.1.0, Culture=neutral, PublicKeyToken=be1b3c0b5819660a, processorArchitecture=MSIL">
-      <HintPath>..\..\packages\csmpfit.1.1.1\lib\net20\MPFitLib.dll</HintPath>
-    </Reference>
-    <Reference Include="OSPSuite.Assets, Version=8.0.4.0, Culture=neutral, processorArchitecture=MSIL">
-      <HintPath>..\..\packages\OSPSuite.Assets.8.0.4\lib\net462\OSPSuite.Assets.dll</HintPath>
-    </Reference>
-    <Reference Include="OSPSuite.Core, Version=8.0.4.0, Culture=neutral, processorArchitecture=MSIL">
-      <HintPath>..\..\packages\OSPSuite.Core.8.0.4\lib\net462\OSPSuite.Core.dll</HintPath>
-    </Reference>
-    <Reference Include="OSPSuite.Engine, Version=8.0.4.0, Culture=neutral, processorArchitecture=AMD64">
-      <HintPath>..\..\packages\OSPSuite.Engine.8.0.4\lib\net462\OSPSuite.Engine.dll</HintPath>
-    </Reference>
-    <Reference Include="OSPSuite.FuncParser, Version=0.0.0.0, Culture=neutral, processorArchitecture=AMD64">
-      <HintPath>..\..\packages\OSPSuite.FuncParser.3.0.1.14\lib\net45\OSPSuite.FuncParser.dll</HintPath>
-    </Reference>
-    <Reference Include="OSPSuite.Presentation, Version=8.0.4.0, Culture=neutral, processorArchitecture=MSIL">
-      <HintPath>..\..\packages\OSPSuite.Presentation.8.0.4\lib\net462\OSPSuite.Presentation.dll</HintPath>
-    </Reference>
-    <Reference Include="OSPSuite.Serializer, Version=2.0.1.4, Culture=neutral, processorArchitecture=MSIL">
-      <HintPath>..\..\packages\OSPSuite.Serializer.2.0.1.4\lib\net45\OSPSuite.Serializer.dll</HintPath>
-    </Reference>
-    <Reference Include="OSPSuite.SimModel, Version=0.0.0.0, Culture=neutral, processorArchitecture=AMD64">
-      <HintPath>..\..\packages\OSPSuite.SimModel.3.0.1.27\lib\net45\OSPSuite.SimModel.dll</HintPath>
-    </Reference>
-    <Reference Include="OSPSuite.TeXReporting, Version=2.1.1.9, Culture=neutral, processorArchitecture=MSIL">
-      <HintPath>..\..\packages\OSPSuite.TeXReporting.2.1.1.9\lib\net45\OSPSuite.TeXReporting.dll</HintPath>
-    </Reference>
-    <Reference Include="OSPSuite.Utility, Version=3.0.1.7, Culture=neutral, processorArchitecture=MSIL">
-      <HintPath>..\..\packages\OSPSuite.Utility.3.0.1.7\lib\net462\OSPSuite.Utility.dll</HintPath>
-    </Reference>
-    <Reference Include="SX, Version=2.7.0.9, Culture=neutral, PublicKeyToken=882b9c044052e7f6, processorArchitecture=MSIL">
-      <HintPath>..\..\packages\OSPSuite.SmartXLS.2.7.0.9\lib\net45\SX.dll</HintPath>
-    </Reference>
-    <Reference Include="System" />
-    <Reference Include="System.Core" />
-    <Reference Include="System.Numerics" />
-    <Reference Include="System.Runtime.Serialization" />
-    <Reference Include="System.ValueTuple, Version=4.0.2.0, Culture=neutral, PublicKeyToken=cc7b13ffcd2ddd51, processorArchitecture=MSIL">
-      <HintPath>..\..\packages\System.ValueTuple.4.4.0\lib\net461\System.ValueTuple.dll</HintPath>
-      <Private>True</Private>
-      <Private>True</Private>
-    </Reference>
-    <Reference Include="System.Xml.Linq" />
-    <Reference Include="System.Data.DataSetExtensions" />
-    <Reference Include="Microsoft.CSharp" />
-    <Reference Include="System.Data" />
-    <Reference Include="System.Net.Http" />
-    <Reference Include="System.Xml" />
+    <Compile Include="..\..\SolutionInfo.cs" Link="Properties\SolutionInfo.cs" />
   </ItemGroup>
+
   <ItemGroup>
-    <Compile Include="..\..\SolutionInfo.cs">
-      <Link>Properties\SolutionInfo.cs</Link>
-    </Compile>
-    <Compile Include="Extensions\DimensionInfoExtensions.cs" />
-    <Compile Include="Sbml\AssignmentImporter.cs" />
-    <Compile Include="Sbml\AssignmentImporterBase.cs" />
-    <Compile Include="Sbml\ASTHandler.cs" />
-    <Compile Include="Sbml\CompartmentImporter.cs" />
-    <Compile Include="Sbml\EventImporter.cs" />
-    <Compile Include="Sbml\FunctionDefinitionImporter.cs" />
-    <Compile Include="Sbml\InitialAssignmentImporter.cs" />
-    <Compile Include="Sbml\MoleculeInformation.cs" />
-    <Compile Include="Sbml\ParameterImporter.cs" />
-    <Compile Include="Sbml\ReactionImporter.cs" />
-    <Compile Include="Sbml\RuleImporter.cs" />
-    <Compile Include="Sbml\SBMLConstants.cs" />
-    <Compile Include="Sbml\SBMLImporter.cs" />
-    <Compile Include="Sbml\SBMLImporterRepository.cs" />
-    <Compile Include="Sbml\SBMLImportRegister.cs" />
-    <Compile Include="Sbml\SBMLInformation.cs" />
-    <Compile Include="Sbml\SbmlTask.cs" />
-    <Compile Include="Sbml\SpeciesImporter.cs" />
-    <Compile Include="Sbml\UnitDefinitionImporter.cs" />
-    <Compile Include="Tasks\DimensionValidator.cs" />
-    <Compile Include="EngineRegister.cs" />
-    <Compile Include="Properties\AssemblyInfo.cs" />
-    <Compile Include="Tasks\SimModelManagerFactory.cs" />
+    <Folder Include="Properties\" />
   </ItemGroup>
+
   <ItemGroup>
-    <None Include="app.config" />
-    <None Include="packages.config" />
+    <PackageReference Include="OSPSuite.Core" Version="9.0.137" />
+    <PackageReference Include="OSPSuite.Assets" Version="9.0.137" />
   </ItemGroup>
+
   <ItemGroup>
-    <ProjectReference Include="..\MoBi.Assets\MoBi.Assets.csproj">
-      <Project>{3c65ffc2-d9ec-4951-8c35-04854ad34e52}</Project>
-      <Name>MoBi.Assets</Name>
-    </ProjectReference>
-    <ProjectReference Include="..\MoBi.Core\MoBi.Core.csproj">
-      <Project>{2DBF50BE-A749-421C-B526-8BDA31CFE7B3}</Project>
-      <Name>MoBi.Core</Name>
-    </ProjectReference>
-    <ProjectReference Include="..\MoBi.Presentation\MoBi.Presentation.csproj">
-      <Project>{B4C86DCA-8877-4400-8088-2401EE65B403}</Project>
-      <Name>MoBi.Presentation</Name>
-    </ProjectReference>
+    <None Include="..\..\LICENSE">
+      <Pack>True</Pack>
+      <PackagePath></PackagePath>
+    </None>
+  </ItemGroup>
+
+  <ItemGroup>
+    <ProjectReference Include="..\MoBi.Assets\MoBi.Assets.csproj" />
+    <ProjectReference Include="..\MoBi.Core\MoBi.Core.csproj" />
+  </ItemGroup>
+
+  <ItemGroup>
+    <Reference Include="libsbmlcsP">
+      <HintPath>..\..\pre\libsbmlcsP.dll</HintPath>
+    </Reference>
   </ItemGroup>
-  <Import Project="$(MSBuildToolsPath)\Microsoft.CSharp.targets" />
-</Project>
\ No newline at end of file
+
+
+</Project>
diff --git a/src/MoBi.Engine/Properties/AssemblyInfo.cs b/src/MoBi.Engine/Properties/AssemblyInfo.cs
deleted file mode 100644
index 936f799b6..000000000
--- a/src/MoBi.Engine/Properties/AssemblyInfo.cs
+++ /dev/null
@@ -1,6 +0,0 @@
-using System.Reflection;
-
-// General Information about an assembly is controlled through the following
-// set of attributes. Change these attribute values to modify the information
-// associated with an assembly.
-[assembly: AssemblyTitle("MoBi.Engine")]
\ No newline at end of file
diff --git a/src/MoBi.Engine/Sbml/SBMLTask.cs b/src/MoBi.Engine/Sbml/SBMLTask.cs
index 8d291102b..457b7036a 100644
--- a/src/MoBi.Engine/Sbml/SBMLTask.cs
+++ b/src/MoBi.Engine/Sbml/SBMLTask.cs
@@ -44,7 +44,7 @@ public IMoBiCommand ImportModelFromSbml(string filename, IMoBiProject project)
          var model = GetModel(filename);
          if (model == null) return new MoBiEmptyCommand();
 
-         initialiseDimensionFactory(project);
+         initialiseDimensionFactory();
          project.Name = getProjectName(model);
 
          reportConstraints(project, model);
@@ -70,11 +70,10 @@ private void reportConstraints(IMoBiProject project, Model model)
          }
       }
 
-      private void initialiseDimensionFactory(IMoBiProject project)
+      private void initialiseDimensionFactory()
       {
          _moBiDimensionFactory = new MoBiDimensionFactory();
-         _mobiContext.DimensionFactory.BaseFactory.Dimensions.Each(_moBiDimensionFactory.BaseFactory.AddDimension);
-         project.DimensionFactory.Dimensions.Each(_moBiDimensionFactory.ProjectFactory.AddDimension);
+         _mobiContext.DimensionFactory.Dimensions.Each(_moBiDimensionFactory.AddDimension);
       }
 
       private string getProjectName(Model model)
diff --git a/src/MoBi.Engine/app.config b/src/MoBi.Engine/app.config
deleted file mode 100644
index c553f0e98..000000000
--- a/src/MoBi.Engine/app.config
+++ /dev/null
@@ -1,23 +0,0 @@
-<?xml version="1.0" encoding="utf-8"?>
-<configuration>
-  <runtime>
-    <assemblyBinding xmlns="urn:schemas-microsoft-com:asm.v1">
-      <dependentAssembly>
-        <assemblyIdentity name="NHibernate" publicKeyToken="aa95f207798dfdb4" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-5.2.0.0" newVersion="5.2.0.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="Iesi.Collections" publicKeyToken="aa95f207798dfdb4" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-4.0.0.4000" newVersion="4.0.0.4000" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="System.Data.SQLite" publicKeyToken="db937bc2d44ff139" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-1.0.110.0" newVersion="1.0.110.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="SX" publicKeyToken="882b9c044052e7f6" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-2.7.0.9" newVersion="2.7.0.9" />
-      </dependentAssembly>
-    </assemblyBinding>
-  </runtime>
-</configuration>
\ No newline at end of file
diff --git a/src/MoBi.Engine/packages.config b/src/MoBi.Engine/packages.config
deleted file mode 100644
index e0ff0893c..000000000
--- a/src/MoBi.Engine/packages.config
+++ /dev/null
@@ -1,18 +0,0 @@
-<?xml version="1.0" encoding="utf-8"?>
-<packages>
-  <package id="csmpfit" version="1.1.1" targetFramework="net462" />
-  <package id="MathNet.Numerics" version="4.7.0" targetFramework="net462" />
-  <package id="Microsoft.Extensions.Logging.Abstractions" version="2.2.0" targetFramework="net462" />
-  <package id="OSPSuite.Assets" version="8.0.4" targetFramework="net462" />
-  <package id="OSPSuite.Core" version="8.0.4" targetFramework="net462" />
-  <package id="OSPSuite.DevExpress.Presentation" version="18.2.7" targetFramework="net462" />
-  <package id="OSPSuite.Engine" version="8.0.4" targetFramework="net462" />
-  <package id="OSPSuite.FuncParser" version="3.0.1.14" targetFramework="net462" />
-  <package id="OSPSuite.Presentation" version="8.0.4" targetFramework="net462" />
-  <package id="OSPSuite.Serializer" version="2.0.1.4" targetFramework="net462" />
-  <package id="OSPSuite.SimModel" version="3.0.1.27" targetFramework="net462" />
-  <package id="OSPSuite.SmartXLS" version="2.7.0.9" targetFramework="net462" />
-  <package id="OSPSuite.TeXReporting" version="2.1.1.9" targetFramework="net462" />
-  <package id="OSPSuite.Utility" version="3.0.1.7" targetFramework="net462" />
-  <package id="System.ValueTuple" version="4.4.0" targetFramework="net462" />
-</packages>
\ No newline at end of file
diff --git a/src/MoBi.Presentation/DTO/OutputIntervalDTO.cs b/src/MoBi.Presentation/DTO/OutputIntervalDTO.cs
deleted file mode 100644
index 362ff7a39..000000000
--- a/src/MoBi.Presentation/DTO/OutputIntervalDTO.cs
+++ /dev/null
@@ -1,8 +0,0 @@
-using BTS.Utility.Validation;
-using MoBi.Resources;
-using SBSuite.Core.Domain;
-
-namespace MoBi.Presentation.DTO
-{
-
-}
\ No newline at end of file
diff --git a/src/MoBi.Presentation/DTO/ParameterDTO.cs b/src/MoBi.Presentation/DTO/ParameterDTO.cs
index 5bfc2fc86..61a7acaec 100644
--- a/src/MoBi.Presentation/DTO/ParameterDTO.cs
+++ b/src/MoBi.Presentation/DTO/ParameterDTO.cs
@@ -31,12 +31,12 @@ public class ParameterDTO : ObjectBaseDTO, ITaggedEntityDTO, IMoBiParameterDTO
       public int Sequence { get; set; }
       public double Percentile { get; set; }
       public PathElements PathElements { get; set; } = new PathElements();
-      public PathElementDTO SimulationPathElement => PathElements[PathElement.Simulation];
-      public PathElementDTO TopContainerPathElement => PathElements[PathElement.TopContainer];
-      public PathElementDTO ContainerPathElement => PathElements[PathElement.Container];
-      public PathElementDTO BottomCompartmentPathElement => PathElements[PathElement.BottomCompartment];
-      public PathElementDTO MoleculePathElement => PathElements[PathElement.Molecule];
-      public PathElementDTO NamePathElement => PathElements[PathElement.Name];
+      public PathElement SimulationPathElement => PathElements[PathElementId.Simulation];
+      public PathElement TopContainerPathElement => PathElements[PathElementId.TopContainer];
+      public PathElement ContainerPathElement => PathElements[PathElementId.Container];
+      public PathElement BottomCompartmentPathElement => PathElements[PathElementId.BottomCompartment];
+      public PathElement MoleculePathElement => PathElements[PathElementId.Molecule];
+      public PathElement NamePathElement => PathElements[PathElementId.Name];
 
       public string Category { get; }
       public string DisplayPathAsString => PathElements.Select(x => x.DisplayName).ToString(Constants.DISPLAY_PATH_SEPARATOR);
diff --git a/src/MoBi.Presentation/DTO/ValueEditDTO.cs b/src/MoBi.Presentation/DTO/ValueEditDTO.cs
index 9b2694fa2..846974134 100644
--- a/src/MoBi.Presentation/DTO/ValueEditDTO.cs
+++ b/src/MoBi.Presentation/DTO/ValueEditDTO.cs
@@ -23,11 +23,8 @@ public virtual double KernelValue
       public double Value
       {
          get => valueToDisplayValue(KernelValue);
-         set
-         {
-            KernelValue = displayValueToValue(value);
-            OnPropertyChanged(() => Value);
-         }
+         //Settings the Kernel Value triggers a Value Change. Event. No need to send it twice
+         set => KernelValue = displayValueToValue(value);
       }
 
       public Unit DisplayUnit
diff --git a/src/MoBi.Presentation/Mappers/DataTableToImportQuantityDTOMapperForMolecules.cs b/src/MoBi.Presentation/Mappers/DataTableToImportQuantityDTOMapperForMolecules.cs
index 4fe976869..f40217620 100644
--- a/src/MoBi.Presentation/Mappers/DataTableToImportQuantityDTOMapperForMolecules.cs
+++ b/src/MoBi.Presentation/Mappers/DataTableToImportQuantityDTOMapperForMolecules.cs
@@ -85,7 +85,7 @@ private bool isDimensionRequired(ImportedQuantityDTO dto)
 
       private static string getDimensionConstantForProject(ReactionDimensionMode dimensionMode)
       {
-         return dimensionMode == ReactionDimensionMode.AmountBased ? Constants.Dimension.AMOUNT : Constants.Dimension.MOLAR_CONCENTRATION;
+         return dimensionMode == ReactionDimensionMode.AmountBased ? Constants.Dimension.MOLAR_AMOUNT : Constants.Dimension.MOLAR_CONCENTRATION;
       }
 
       private bool isCorrectDimensionForDimensionMode(ReactionDimensionMode dimensionMode, ImportedQuantityDTO dto)
@@ -93,7 +93,7 @@ private bool isCorrectDimensionForDimensionMode(ReactionDimensionMode dimensionM
          if (dto.Dimension == _dimensionFactory.Dimension(Constants.Dimension.MOLAR_CONCENTRATION) && dimensionMode == ReactionDimensionMode.ConcentrationBased)
             return true;
 
-         if (dto.Dimension == _dimensionFactory.Dimension(Constants.Dimension.AMOUNT) && dimensionMode == ReactionDimensionMode.AmountBased)
+         if (dto.Dimension == _dimensionFactory.Dimension(Constants.Dimension.MOLAR_AMOUNT) && dimensionMode == ReactionDimensionMode.AmountBased)
             return true;
 
          return false;
diff --git a/src/MoBi.Presentation/Mappers/MoBiQuantityPathToQuantityDisplayPathMapper.cs b/src/MoBi.Presentation/Mappers/MoBiQuantityPathToQuantityDisplayPathMapper.cs
index 19a746a41..512258d9d 100644
--- a/src/MoBi.Presentation/Mappers/MoBiQuantityPathToQuantityDisplayPathMapper.cs
+++ b/src/MoBi.Presentation/Mappers/MoBiQuantityPathToQuantityDisplayPathMapper.cs
@@ -2,8 +2,7 @@
 using MoBi.Core.Domain.Model.Diagram;
 using MoBi.Presentation.Settings;
 using OSPSuite.Core.Domain;
-using OSPSuite.Presentation.DTO;
-using OSPSuite.Presentation.Mappers;
+using OSPSuite.Core.Domain.Mappers;
 
 namespace MoBi.Presentation.Mappers
 {
@@ -18,19 +17,19 @@ public MoBiQuantityPathToQuantityDisplayPathMapper(IObjectPathFactory objectPath
          _userSettings = userSettings;
       }
 
-      protected override IEnumerable<PathElement> DefaultPathElementsToUse(bool addTopContainerName, PathElements pathElements)
+      protected override IEnumerable<PathElementId> DefaultPathElementsToUse(bool addTopContainerName, PathElements pathElements)
       {
          if (addTopContainerName || chartOptions.SimulationInCurveName)
-            yield return PathElement.Simulation;
+            yield return PathElementId.Simulation;
 
-         //Observed data repository name is stored in PathElement.TopContainer. So if the top container name is to be displayed, we need to add it as well 
+         //Observed data repository name is stored in PathElementId.TopContainer. So if the top container name is to be displayed, we need to add it as well 
          if (addTopContainerName || chartOptions.TopContainerInCurveName)
-            yield return PathElement.TopContainer;
+            yield return PathElementId.TopContainer;
 
-         yield return PathElement.Container;
-         yield return PathElement.BottomCompartment;
-         yield return PathElement.Molecule;
-         yield return PathElement.Name;
+         yield return PathElementId.Container;
+         yield return PathElementId.BottomCompartment;
+         yield return PathElementId.Molecule;
+         yield return PathElementId.Name;
       }
    }
 }
\ No newline at end of file
diff --git a/src/MoBi.Presentation/Mappers/ParameterToParameterDTOMapper.cs b/src/MoBi.Presentation/Mappers/ParameterToParameterDTOMapper.cs
index bc7560e75..e1acd525d 100644
--- a/src/MoBi.Presentation/Mappers/ParameterToParameterDTOMapper.cs
+++ b/src/MoBi.Presentation/Mappers/ParameterToParameterDTOMapper.cs
@@ -1,9 +1,9 @@
 using MoBi.Presentation.DTO;
 using OSPSuite.Core.Domain;
+using OSPSuite.Core.Domain.Mappers;
 using OSPSuite.Core.Domain.Repositories;
 using OSPSuite.Core.Domain.Services;
 using OSPSuite.Presentation.DTO;
-using OSPSuite.Presentation.Mappers;
 using OSPSuite.Utility.Extensions;
 
 namespace MoBi.Presentation.Mappers
diff --git a/src/MoBi.Presentation/MenusAndBars/ContextMenus/ContextMenuFactoryForContainer.cs b/src/MoBi.Presentation/MenusAndBars/ContextMenus/ContextMenuFactoryForContainer.cs
index 30a2611f0..389b31efc 100644
--- a/src/MoBi.Presentation/MenusAndBars/ContextMenus/ContextMenuFactoryForContainer.cs
+++ b/src/MoBi.Presentation/MenusAndBars/ContextMenus/ContextMenuFactoryForContainer.cs
@@ -1,5 +1,3 @@
-using OSPSuite.Utility.Container;
-using OSPSuite.Utility.Extensions;
 using MoBi.Core.Domain.Model;
 using MoBi.Presentation.DTO;
 using MoBi.Presentation.Presenter;
@@ -8,6 +6,8 @@
 using OSPSuite.Presentation.Core;
 using OSPSuite.Presentation.Presenters;
 using OSPSuite.Presentation.Presenters.ContextMenus;
+using OSPSuite.Utility.Container;
+using OSPSuite.Utility.Extensions;
 using IContainer = OSPSuite.Core.Domain.IContainer;
 
 namespace MoBi.Presentation.MenusAndBars.ContextMenus
@@ -26,9 +26,9 @@ public override IContextMenu CreateFor(IObjectBaseDTO objectBaseDTO, IPresenterW
 
       protected override bool IsSatisfiedBy(IEntity entity, IPresenterWithContextMenu<IViewItem> presenter)
       {
-         return presenter.IsAnImplementationOf<IHierarchicalStructurePresenter>() 
-            && entity.IsAnImplementationOf<IContainer>() 
-            && !entity.IsAnImplementationOf<INeighborhoodBuilder>();
+         return presenter.IsAnImplementationOf<IHierarchicalSpatialStructurePresenter>()
+                && entity.IsAnImplementationOf<IContainer>()
+                && !entity.IsAnImplementationOf<INeighborhoodBuilder>();
       }
    }
 }
\ No newline at end of file
diff --git a/src/MoBi.Presentation/MenusAndBars/ContextMenus/ContextMenuForContainer.cs b/src/MoBi.Presentation/MenusAndBars/ContextMenus/ContextMenuForContainer.cs
index 515d0f401..d96b6ef31 100644
--- a/src/MoBi.Presentation/MenusAndBars/ContextMenus/ContextMenuForContainer.cs
+++ b/src/MoBi.Presentation/MenusAndBars/ContextMenus/ContextMenuForContainer.cs
@@ -1,17 +1,15 @@
 using MoBi.Assets;
-using OSPSuite.Presentation.MenuAndBars;
 using MoBi.Core.Domain.Extensions;
 using MoBi.Core.Domain.Model;
-using MoBi.Core.Helper;
 using MoBi.Presentation.DTO;
 using MoBi.Presentation.UICommand;
+using OSPSuite.Assets;
 using OSPSuite.Core.Domain;
 using OSPSuite.Core.Domain.Services;
 using OSPSuite.Presentation.Core;
+using OSPSuite.Presentation.MenuAndBars;
 using OSPSuite.Presentation.Presenters;
 using OSPSuite.Presentation.Presenters.ContextMenus;
-using OSPSuite.Assets;
-using RemoveTopContainerCommand = MoBi.Presentation.UICommand.RemoveTopContainerCommand;
 
 namespace MoBi.Presentation.MenusAndBars.ContextMenus
 {
@@ -21,7 +19,7 @@ public interface IContextMenuForContainer : IContextMenuFor<IContainer>
 
    public class ContextMenuForContainerBase<TContainer> : ContextMenuFor<TContainer> where TContainer : class, IContainer
    {
-      public ContextMenuForContainerBase(IMoBiContext context, IObjectTypeResolver objectTypeResolver) : base( context, objectTypeResolver)
+      public ContextMenuForContainerBase(IMoBiContext context, IObjectTypeResolver objectTypeResolver) : base(context, objectTypeResolver)
       {
       }
 
@@ -49,8 +47,8 @@ protected override IMenuBarItem CreateDeleteItemFor(TContainer objectToRemove)
       {
          if (objectToRemove.ParentContainer != null)
             return CreateMenuButton.WithCaption(AppConstants.MenuNames.Delete)
-            .WithCommandFor<RemoveCommandForContainer, IContainer>(objectToRemove)
-            .WithIcon(ApplicationIcons.Delete);
+               .WithCommandFor<RemoveCommandForContainer, IContainer>(objectToRemove)
+               .WithIcon(ApplicationIcons.Delete);
 
          return CreateMenuButton.WithCaption(AppConstants.MenuNames.Delete)
             .WithCommandFor<RemoveTopContainerCommand, IContainer>(objectToRemove)
@@ -73,7 +71,6 @@ private IMenuBarItem createAddExistingFromTemplateItemFor<T>(TContainer parent)
             .WithCommandFor<AddExistingFromTemplateCommandFor<IContainer, T>, IContainer>(parent);
       }
 
-
       protected IMenuBarItem CreateAddNewChild<T>(TContainer container) where T : class, IEntity
       {
          var typeName = _objectTypeResolver.TypeFor<T>();
@@ -98,6 +95,7 @@ public override IContextMenu InitializeWith(IObjectBaseDTO dto, IPresenter prese
             _allMenuItems.Add(CreateAddNewItemFor(container));
             _allMenuItems.Add(CreateAddExistingItemFor(container));
          }
+
          _allMenuItems.Add(CreateAddNewChild<IDistributedParameter>(container));
          return this;
       }
diff --git a/src/MoBi.Presentation/MenusAndBars/ContextMenus/ContextMenuForSimulation.cs b/src/MoBi.Presentation/MenusAndBars/ContextMenus/ContextMenuForSimulation.cs
index 72b587893..30e959de1 100644
--- a/src/MoBi.Presentation/MenusAndBars/ContextMenus/ContextMenuForSimulation.cs
+++ b/src/MoBi.Presentation/MenusAndBars/ContextMenus/ContextMenuForSimulation.cs
@@ -50,8 +50,10 @@ public IContextMenu InitializeWith(IObjectBaseDTO dto, IPresenter presenter)
             createReportItemFor(simulation),
             createAddToJournal(simulation),
             exportSimulationResultsToExcel(simulation),
-            createExportForMatlabItem(simulation),
-            createMatlabODEExportItem(simulation),
+            createExportODEForMatlabItem(simulation),
+            createExportODEForRItem(simulation),
+            createExportForSimModelXmlItem(simulation),
+            createExportForCppItem(simulation),
             createDebugReportItem(simulation),
             createExportModelPartsItem(simulation),
 
@@ -92,13 +94,21 @@ private IMenuBarItem createRunItem(IMoBiSimulation simulation)
                .AsGroupStarter();
       }
 
-      private IMenuBarItem createMatlabODEExportItem(IMoBiSimulation simulation)
+      private IMenuBarItem createExportODEForMatlabItem(IMoBiSimulation simulation)
       {
-         return CreateMenuButton.WithCaption(AppConstants.MenuNames.MatlabDifferentialSystemExport)
-            .WithCommandFor<ExportMatlabODEUICommand, IMoBiSimulation>(simulation)
+         return CreateMenuButton.WithCaption(MenuNames.ExportODEForMatlab)
+            .WithCommandFor<ExportODEForMatlabUICommand, IMoBiSimulation>(simulation)
             .WithIcon(ApplicationIcons.Matlab);
       }
 
+      private IMenuBarItem createExportODEForRItem(IMoBiSimulation simulation)
+      {
+         return CreateMenuButton.WithCaption(MenuNames.AsDeveloperOnly(MenuNames.ExportODEForR))
+            .WithCommandFor<ExportODEForRUICommand, IMoBiSimulation>(simulation)
+            .WithIcon(ApplicationIcons.R)
+            .ForDeveloper();
+      }
+
       private IMenuBarItem createParameterIdentificationItem(IMoBiSimulation simulation)
       {
          return ParameterIdentificationContextMenuItems.CreateParameterIdentificationFor(new[] {simulation});
@@ -111,11 +121,18 @@ private IMenuBarItem createDebugReportItem(IMoBiSimulation simulation)
             .WithCommandFor<CreateSimulationReportUICommand, IMoBiSimulation>(simulation);
       }
 
-      private IMenuBarItem createExportForMatlabItem(IMoBiSimulation simulation)
+      private IMenuBarItem createExportForSimModelXmlItem(IMoBiSimulation simulation)
       {
-         return CreateMenuButton.WithCaption(AppConstants.MenuNames.ExportSimModelXml)
-            .WithCommandFor<ExportSimulationToSimModelXml, IMoBiSimulation>(simulation)
-            .WithIcon(ApplicationIcons.Matlab);
+         return CreateMenuButton.WithCaption(MenuNames.ExportSimModelXml)
+            .WithCommandFor<ExportSimulationToSimModelXmlUICommand, IMoBiSimulation>(simulation)
+            .ForDeveloper();
+      }
+
+      private IMenuBarItem createExportForCppItem(IMoBiSimulation simulation)
+      {
+         return CreateMenuButton.WithCaption(MenuNames.ExportForCpp)
+            .WithCommandFor<ExportSimulationToCppUICommand, IMoBiSimulation>(simulation)
+            .ForDeveloper();
       }
 
       private IMenuBarItem createStartPopulationSimulation(IMoBiSimulation simulation)
diff --git a/src/MoBi.Presentation/MoBi.Presentation.csproj b/src/MoBi.Presentation/MoBi.Presentation.csproj
index 85d60ca38..566867c65 100644
--- a/src/MoBi.Presentation/MoBi.Presentation.csproj
+++ b/src/MoBi.Presentation/MoBi.Presentation.csproj
@@ -1,994 +1,49 @@
-<?xml version="1.0" encoding="utf-8"?>
-<Project ToolsVersion="12.0" DefaultTargets="Build" xmlns="http://schemas.microsoft.com/developer/msbuild/2003">
+<Project Sdk="Microsoft.NET.Sdk">
+
   <PropertyGroup>
-    <Configuration Condition=" '$(Configuration)' == '' ">Debug</Configuration>
-    <Platform Condition=" '$(Platform)' == '' ">AnyCPU</Platform>
-    <ProductVersion>9.0.21022</ProductVersion>
-    <SchemaVersion>2.0</SchemaVersion>
-    <ProjectGuid>{B4C86DCA-8877-4400-8088-2401EE65B403}</ProjectGuid>
-    <OutputType>Library</OutputType>
-    <AppDesignerFolder>Properties</AppDesignerFolder>
-    <RootNamespace>MoBi.Presentation</RootNamespace>
-    <AssemblyName>MoBi.Presentation</AssemblyName>
-    <TargetFrameworkVersion>v4.6.2</TargetFrameworkVersion>
-    <FileAlignment>512</FileAlignment>
-    <FileUpgradeFlags>
-    </FileUpgradeFlags>
-    <UpgradeBackupLocation>
-    </UpgradeBackupLocation>
-    <OldToolsVersion>3.5</OldToolsVersion>
-    <TargetFrameworkProfile />
-    <NuGetPackageImportStamp>
-    </NuGetPackageImportStamp>
-  </PropertyGroup>
-  <PropertyGroup Condition=" '$(Configuration)|$(Platform)' == 'Debug|AnyCPU' ">
-    <DebugSymbols>true</DebugSymbols>
-    <DebugType>full</DebugType>
-    <Optimize>false</Optimize>
-    <OutputPath>bin\Debug\</OutputPath>
-    <DefineConstants>DEBUG;TRACE</DefineConstants>
-    <ErrorReport>prompt</ErrorReport>
-    <WarningLevel>4</WarningLevel>
-    <DocumentationFile>bin\Debug\MoBi.Presentation.XML</DocumentationFile>
+    <TargetFramework>net472</TargetFramework>
+    <Version>9.0.0</Version>
+    <PackageVersion>9.0.0</PackageVersion>
+    <AssemblyVersion>9.0.0</AssemblyVersion>
+    <FileVersion>9.0.0</FileVersion>
+    <InformationalVersion>9.0.0</InformationalVersion>
+    <GenerateAssemblyProductAttribute>false</GenerateAssemblyProductAttribute>
+    <GenerateAssemblyCompanyAttribute>false</GenerateAssemblyCompanyAttribute>
+    <Authors>Open-Systems-Pharmacology</Authors>
+    <PackageLicenseFile>LICENSE</PackageLicenseFile>
+    <OutputPath>bin\$(Configuration)</OutputPath>
+    <DocumentationFile>bin\$(Configuration)\$(TargetFramework)\$(AssemblyName).xml</DocumentationFile>
     <NoWarn>1591</NoWarn>
-    <Prefer32Bit>false</Prefer32Bit>
-    <PlatformTarget>AnyCPU</PlatformTarget>
-  </PropertyGroup>
-  <PropertyGroup Condition=" '$(Configuration)|$(Platform)' == 'Release|AnyCPU' ">
-    <DebugType>pdbonly</DebugType>
-    <Optimize>true</Optimize>
-    <OutputPath>bin\Release\</OutputPath>
-    <DefineConstants>TRACE</DefineConstants>
-    <ErrorReport>prompt</ErrorReport>
-    <WarningLevel>4</WarningLevel>
-    <Prefer32Bit>false</Prefer32Bit>
   </PropertyGroup>
+
+  <ItemGroup>
+    <Compile Include="..\..\SolutionInfo.cs" Link="Properties\SolutionInfo.cs" />
+  </ItemGroup>
+
   <ItemGroup>
-    <Reference Include="Antlr3.Runtime, Version=3.5.0.2, Culture=neutral, PublicKeyToken=eb42632606e9261f, processorArchitecture=MSIL">
-      <HintPath>..\..\packages\Antlr3.Runtime.3.5.1\lib\net40-client\Antlr3.Runtime.dll</HintPath>
-    </Reference>
-    <Reference Include="Castle.Core, Version=4.0.0.0, Culture=neutral, PublicKeyToken=407dd0808d44fbdc, processorArchitecture=MSIL">
-      <HintPath>..\..\packages\Castle.Core.4.3.1\lib\net45\Castle.Core.dll</HintPath>
-    </Reference>
-    <Reference Include="Castle.Windsor, Version=4.0.0.0, Culture=neutral, PublicKeyToken=407dd0808d44fbdc, processorArchitecture=MSIL">
-      <HintPath>..\..\packages\Castle.Windsor.4.1.1\lib\net45\Castle.Windsor.dll</HintPath>
-    </Reference>
-    <Reference Include="Dapper, Version=1.60.0.0, Culture=neutral, processorArchitecture=MSIL">
-      <HintPath>..\..\packages\Dapper.1.60.6\lib\net451\Dapper.dll</HintPath>
-    </Reference>
-    <Reference Include="DevExpress.Data.v18.2, Version=18.2.7.0, Culture=neutral, PublicKeyToken=b88d1754d700e49a, processorArchitecture=MSIL">
-      <HintPath>..\..\packages\OSPSuite.DevExpress.Presentation.18.2.7\lib\net45\DevExpress.Data.v18.2.dll</HintPath>
-    </Reference>
-    <Reference Include="DevExpress.Utils.v18.2, Version=18.2.7.0, Culture=neutral, PublicKeyToken=b88d1754d700e49a, processorArchitecture=MSIL">
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-    </Reference>
-    <Reference Include="FakeItEasy, Version=5.0.0.0, Culture=neutral, PublicKeyToken=eff28e2146d5fd2c, processorArchitecture=MSIL">
-      <HintPath>..\..\packages\FakeItEasy.5.1.1\lib\net45\FakeItEasy.dll</HintPath>
-    </Reference>
-    <Reference Include="FluentNHibernate, Version=2.1.2.0, Culture=neutral, processorArchitecture=MSIL">
-      <HintPath>..\..\packages\FluentNHibernate.2.1.2\lib\net461\FluentNHibernate.dll</HintPath>
-    </Reference>
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-    </Reference>
-    <Reference Include="Iesi.Collections, Version=4.0.0.4000, Culture=neutral, PublicKeyToken=aa95f207798dfdb4, processorArchitecture=MSIL">
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-    </Reference>
-    <Reference Include="MathNet.Numerics, Version=4.7.0.0, Culture=neutral, processorArchitecture=MSIL">
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-    <Reference Include="Microsoft.CSharp" />
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-    <Compile Include="Views\ICalculateScaleDivisorsView.cs" />
-    <Compile Include="Views\ICreateBuildingBlockMergeView.cs" />
-    <Compile Include="Views\ICreatePKSimMoleculeView.cs" />
-    <Compile Include="Views\ICreateSimulationView.cs" />
-    <Compile Include="Views\ICreateStartValuesView.cs" />
-    <Compile Include="Views\IDescriptorConditionListView.cs" />
-    <Compile Include="Views\IEditBuildConfigurationView.cs" />
-    <Compile Include="Views\IEditBuildingBlockBaseView.cs" />
-    <Compile Include="Views\ICreateSpatialStructureView.cs" />
-    <Compile Include="Views\IEditActiveTransportBuilderContainerView.cs" />
-    <Compile Include="Views\IEditApplicationBuilderView.cs" />
-    <Compile Include="Views\IEditApplicationMoleculeBuilderView.cs" />
-    <Compile Include="Views\IEditDistributedParameterView.cs" />
-    <Compile Include="Views\IEditTypedFormulaView.cs" />
-    <Compile Include="Views\IEditEventAssignmentBuilderView.cs" />
-    <Compile Include="Views\IEditFormulaView.cs" />
-    <Compile Include="Views\IEditOutputSchemaView.cs" />
-    <Compile Include="Views\IEditParametersInContainerView.cs" />
-    <Compile Include="Views\IEditQuantityInSimulationView.cs" />
-    <Compile Include="Views\IEditSimulationSettingsView.cs" />
-    <Compile Include="Views\IEditSumFormulaView.cs" />
-    <Compile Include="Views\IEditTableFormulaView.cs" />
-    <Compile Include="Views\IEditTableFormulaWithOffSetFormulaView.cs" />
-    <Compile Include="Views\IExportSelectedQuantitiesView.cs" />
-    <Compile Include="Views\IImportMoleculeStartValuesView.cs" />
-    <Compile Include="Views\IImportQuantityView.cs" />
-    <Compile Include="Views\IMergeConflictResolverView.cs" />
-    <Compile Include="Views\IMoleculeDependentBuilderView.cs" />
-    <Compile Include="Views\INotificationView.cs" />
-    <Compile Include="Views\IFormulaCacheView.cs" />
-    <Compile Include="Views\IMoleculeStartValuesView.cs" />
-    <Compile Include="Views\IMultipleStringSelectionView.cs" />
-    <Compile Include="Views\IBuildingBlockExplorerView.cs" />
-    <Compile Include="Views\IObjectBaseSummaryView.cs" />
-    <Compile Include="Views\IParameterStartValuesView.cs" />
-    <Compile Include="Views\IReactionBuilderView.cs" />
-    <Compile Include="Views\ISearchView.cs" />
-    <Compile Include="Views\ISelectEventAssignmentTargetView.cs" />
-    <Compile Include="Views\ISelectFormulaUsablePathView.cs" />
-    <Compile Include="Views\ISelectLocalisationView.cs" />
-    <Compile Include="Views\ISelectManyView.cs" />
-    <Compile Include="Views\ISelectMoleculesForBuildingBlockView.cs" />
-    <Compile Include="Views\ISelectReferenceView.cs" />
-    <Compile Include="Views\ISelectRenamingView.cs" />
-    <Compile Include="Views\ISelectFormulasForObjectBaseView.cs" />
-    <Compile Include="Views\IEditReactionInSimulationView.cs" />
-    <Compile Include="Views\ISimulationExplorerView.cs" />
-    <Compile Include="Views\IOutputSelectionsView.cs" />
-    <Compile Include="Views\ISolverMessageView.cs" />
-    <Compile Include="Views\ISplashScreen.cs" />
-    <Compile Include="Views\IStartValuesView.cs" />
-    <Compile Include="Views\IProjectChartView.cs" />
-    <Compile Include="Views\IUserDefinedParametersView.cs" />
-    <Compile Include="Views\IUserSettingsView.cs" />
-    <Compile Include="Presenter\EditEventGroupBuildingBlockPresenter.cs" />
-    <Compile Include="Presenter\EditEventGroupPresenter.cs" />
-    <Compile Include="Presenter\EditMoleculeBuilderPresenter.cs" />
-    <Compile Include="Presenter\EditObserverBuilderPresenter.cs" />
-    <Compile Include="Presenter\EditObserverBuildingBlockPresenter.cs" />
-    <Compile Include="Presenter\EventGroupListPresenter.cs" />
-    <Compile Include="Presenter\MoleculeListPresenter.cs" />
-    <Compile Include="Presenter\ObserverBuilderListPresenter.cs" />
-    <Compile Include="Presenter\ReactionDiagram\IReactionDiagramPresenter.cs" />
-    <Compile Include="Presenter\ReactionDiagram\ReactionPopupMenus.cs" />
-    <Compile Include="Tasks\ObservedDataTask.cs" />
-    <Compile Include="UICommand\ImportDataRepositoryUICommand.cs" />
-    <Compile Include="Presenter\BaseDiagram\BasePopupMenus.cs" />
-    <Compile Include="Presenter\CreateSimulationPresenter.cs" />
-    <Compile Include="Presenter\EditBuildConfigurationPresenter.cs" />
-    <Compile Include="Presenter\EditContainerPresenter.cs" />
-    <Compile Include="Presenter\SelectAndEditMoleculesStartValuesPresenter.cs" />
-    <Compile Include="Presenter\EditMoleculeStartValuesPresenter.cs" />
-    <Compile Include="Presenter\EditParameterPresenter.cs" />
-    <Compile Include="Presenter\EditParameterStartValuesPresenter.cs" />
-    <Compile Include="Presenter\EditTransportBuilderPresenter.cs" />
-    <Compile Include="Presenter\EditPassiveTransportBuildingBlockPresenter.cs" />
-    <Compile Include="Presenter\EditSolverSettingsPresenter.cs" />
-    <Compile Include="Presenter\EditSpatialStructurePresenter.cs" />
-    <Compile Include="Views\IEditEventGroupBuildingBlockView.cs" />
-    <Compile Include="Views\IEditEventGroupView.cs" />
-    <Compile Include="Views\IEditEventBuilderView.cs" />
-    <Compile Include="Views\IEditMoleculeBuilderView.cs" />
-    <Compile Include="Views\IEditObserverBuilderView.cs" />
-    <Compile Include="Views\IEditObserverBuildingBlockView.cs" />
-    <Compile Include="Views\IEditPassiveTransportBuildingBlockView.cs" />
-    <Compile Include="Views\IEditTransportBuilderView.cs" />
-    <Compile Include="Presenter\ModelDiagram\ModelPopupMenus.cs" />
-    <Compile Include="Presenter\ModelDiagram\SimulationDiagramPresenter.cs" />
-    <Compile Include="Presenter\HierarchicalSimulationPresenter.cs" />
-    <Compile Include="Presenter\BuildingBlockSelectionPresenter.cs" />
-    <Compile Include="Presenter\BaseDiagram\MoBiBaseDiagramPresenter.cs" />
-    <Compile Include="Presenter\SpaceDiagram\SpacePopupMenus.cs" />
-    <Compile Include="Presenter\SpaceDiagram\SpatialStructureDiagramPresenter.cs" />
-    <Compile Include="Presenter\EditSimulationPresenter.cs" />
-    <Compile Include="Views\IEventGroupsListView.cs" />
-    <Compile Include="Views\IMoleculeListView.cs" />
-    <Compile Include="Views\IObserverListView.cs" />
-    <Compile Include="Views\IEditSimulationView.cs" />
-    <Compile Include="Views\IFinalOptionsView.cs" />
-    <Compile Include="Views\ISelectAndEditContainerView.cs" />
-    <Compile Include="Views\IEditMoleculeStartValuesView.cs" />
-    <Compile Include="Views\IEditParameterStartValuesView.cs" />
-    <Compile Include="Views\IEditSolverSettingsView.cs" />
-    <Compile Include="Presenter\SelectAndEditParameterStartValuesPresenter.cs" />
-    <Compile Include="Presenter\FinalOptionsPresenter.cs" />
-    <Compile Include="Presenter\HierarchicalStructurePresenter.cs" />
-    <Compile Include="Views\IEditContainerView.cs" />
-    <Compile Include="Views\IEditParameterView.cs" />
-    <Compile Include="Views\IEditSpatialStructureView.cs" />
-    <Compile Include="Presenter\EditDimensionPresenter.cs" />
-    <Compile Include="Presenter\EditUnitPresenter.cs" />
-    <Compile Include="Tasks\UnitTasks.cs" />
-    <Compile Include="Views\IEditUnitView.cs" />
-    <Compile Include="Views\IHierarchicalStructureView.cs" />
-    <Compile Include="Presenter\EditExplicitFormulaPresenter.cs" />
-    <Compile Include="Views\IEditExplicitFormulaView.cs" />
-    <Compile Include="Presenter\EditConstantFormulaPresenter.cs" />
-    <Compile Include="Presenter\CreateFormulaPresenter.cs" />
-    <Compile Include="Views\IEditConstantFormulaView.cs" />
-    <Compile Include="Views\INameEdit.cs" />
-    <Compile Include="UICommand\ReactionPartnerBuilderUICommands.cs" />
-    <Compile Include="Presenter\EditMoleculeBuildingBlockPresenter.cs" />
-    <Compile Include="Presenter\EditReactionBuildingBlockPresenter.cs" />
-    <Compile Include="Presenter\EditReactionBuilderPresenter.cs" />
-    <Compile Include="Views\IEditReactionBuilderView.cs" />
-    <Compile Include="Presenter\ReactionsListSubPresenter.cs" />
-    <Compile Include="UICommand\EditCommandFor.cs" />
-    <Compile Include="UICommand\AddCommandFor.cs" />
-    <Compile Include="MenusAndBars\MenuBarItemExtensions.cs" />
-    <Compile Include="MenusAndBars\MenuBarItemIds.cs" />
-    <Compile Include="PresentationRegister.cs" />
-    <Compile Include="Presenter\ChartPresenter.cs">
-    </Compile>
-    <Compile Include="Presenter\IPresenter.cs" />
-    <Compile Include="Views\IEditMoleculesBuildingBlockView.cs" />
-    <Compile Include="Views\IEditReactionBuildingBlockView.cs" />
-    <Compile Include="Views\IReactionListView.cs" />
-    <Compile Include="Views\IValidationOptionsView.cs" />
-    <Compile Include="Views\IView.cs" />
-    <Compile Include="UICommand\IExitCommand.cs" />
-    <Compile Include="UICommand\ShowHistoryCommand.cs" />
-    <Compile Include="UICommand\StopSimulationCommand.cs" />
-    <Compile Include="UICommand\RunActiveSimulationCommand.cs" />
-    <Compile Include="UICommand\UserSettingsCommand.cs" />
-    <Compile Include="UICommand\CloseProjectCommand.cs" />
-    <Compile Include="UICommand\NewSimulationCommand.cs" />
-    <Compile Include="Repositories\MenuBarItemRepository.cs" />
-    <Compile Include="UICommand\SaveProjectAsCommand.cs" />
-    <Compile Include="UICommand\SaveProjectCommand.cs" />
-    <Compile Include="Tasks\ChartTasks.cs" />
-    <Compile Include="UICommand\NewProjectCommand.cs" />
-    <Compile Include="UICommand\OpenProjectCommand.cs" />
-    <Compile Include="Tasks\ProjectTask.cs" />
-    <Compile Include="Views\IChartView.cs" />
-    <Compile Include="Presenter\IValidationMessagesPresenter.cs" />
-    <Compile Include="Presenter\DimensionCreationPresenter.cs" />
-    <Compile Include="Presenter\DropAllowedTypes.cs" />
-    <Compile Include="Presenter\MoBiMainViewPresenter.cs">
-    </Compile>
-    <Compile Include="Presenter\SelectionPresenter.cs" />
-    <Compile Include="Properties\AssemblyInfo.cs" />
-    <Compile Include="Views\IEditDimensionView.cs" />
-    <Compile Include="Views\IMoBiMainView.cs" />
-    <Compile Include="Views\IContainerModalView.cs" />
-    <Compile Include="Views\ISelectionView.cs" />
-    <Compile Include="Views\IValidationMessagesView.cs" />
-    <Compile Include="Views\BaseDiagram\IBaseLayouterInterfaces.cs" />
+    <PackageReference Include="Northwoods.GoWin" Version="5.2.0" />
+    <PackageReference Include="OSPSuite.Presentation" Version="9.0.137" />
+    <PackageReference Include="OSPSuite.Presentation.Importer" Version="9.0.137" />
+    <PackageReference Include="OSPSuite.Presentation.Serialization" Version="9.0.137" />
+    <PackageReference Include="OSPSuite.TeXReporting" Version="3.0.0.4" />
+    <PackageReference Include="OSPSuite.Utility" Version="4.0.0.4" />
+    <PackageReference Include="OSPSuite.Core" Version="9.0.137" />
   </ItemGroup>
+
   <ItemGroup>
-    <None Include="app.config" />
-    <None Include="packages.config" />
+    <None Include="..\..\LICENSE">
+      <Pack>True</Pack>
+      <PackagePath></PackagePath>
+    </None>
   </ItemGroup>
+
   <ItemGroup>
-    <ProjectReference Include="..\MoBi.Core\MoBi.Core.csproj">
-      <Project>{2dbf50be-a749-421c-b526-8bda31cfe7b3}</Project>
-      <Name>MoBi.Core</Name>
-    </ProjectReference>
-    <ProjectReference Include="..\MoBi.Assets\MoBi.Assets.csproj">
-      <Project>{3c65ffc2-d9ec-4951-8c35-04854ad34e52}</Project>
-      <Name>MoBi.Assets</Name>
-    </ProjectReference>
+    <ProjectReference Include="..\MoBi.Assets\MoBi.Assets.csproj" />
+    <ProjectReference Include="..\MoBi.Core\MoBi.Core.csproj" />
   </ItemGroup>
-  <ItemGroup />
-  <Import Project="$(MSBuildToolsPath)\Microsoft.CSharp.targets" />
-  <Import Project="..\..\packages\System.Data.SQLite.Core.1.0.110.0\build\net46\System.Data.SQLite.Core.targets" Condition="Exists('..\..\packages\System.Data.SQLite.Core.1.0.110.0\build\net46\System.Data.SQLite.Core.targets')" />
-  <Target Name="EnsureNuGetPackageBuildImports" BeforeTargets="PrepareForBuild">
-    <PropertyGroup>
-      <ErrorText>This project references NuGet package(s) that are missing on this computer. Use NuGet Package Restore to download them.  For more information, see http://go.microsoft.com/fwlink/?LinkID=322105. The missing file is {0}.</ErrorText>
-    </PropertyGroup>
-    <Error Condition="!Exists('..\..\packages\System.Data.SQLite.Core.1.0.110.0\build\net46\System.Data.SQLite.Core.targets')" Text="$([System.String]::Format('$(ErrorText)', '..\..\packages\System.Data.SQLite.Core.1.0.110.0\build\net46\System.Data.SQLite.Core.targets'))" />
-  </Target>
-  <!-- To modify your build process, add your task inside one of the targets below and uncomment it. 
-       Other similar extension points exist, see Microsoft.Common.targets.
-  <Target Name="BeforeBuild">
-  </Target>
-  <Target Name="AfterBuild">
-  </Target>
-  -->
-</Project>
\ No newline at end of file
+
+</Project>
diff --git a/src/MoBi.Presentation/PresentationRegister.cs b/src/MoBi.Presentation/PresentationRegister.cs
index da1794bc6..c324a7306 100644
--- a/src/MoBi.Presentation/PresentationRegister.cs
+++ b/src/MoBi.Presentation/PresentationRegister.cs
@@ -55,15 +55,15 @@ namespace MoBi.Presentation
 {
    public class PresentationRegister : Register
    {
-      private readonly bool _registerMainViewpresenter;
+      private readonly bool _registerMainViewPresenter;
 
       public PresentationRegister() : this(true)
       {
       }
 
-      public PresentationRegister(bool registerMainViewpresenter)
+      public PresentationRegister(bool registerMainViewPresenter)
       {
-         _registerMainViewpresenter = registerMainViewpresenter;
+         _registerMainViewPresenter = registerMainViewPresenter;
       }
 
       public override void RegisterInContainer(IContainer container)
@@ -125,6 +125,7 @@ public override void RegisterInContainer(IContainer container)
          container.Register<IDisplayNameProvider, DisplayNameProvider>();
          container.Register<IRenameObjectDTOFactory, RenameObjectDTOFactory>();
 
+         container.AddRegister(x=>x.FromType<OSPSuite.Presentation.Importer.PresentationImporterRegister>());
          registerTasks(container);
          registerContextMenus(container);
 
@@ -159,7 +160,7 @@ private static void registerContextMenuAndCommands(IContainer container)
 
       private void registerMainPresenters(IContainer container)
       {
-         if (_registerMainViewpresenter)
+         if (_registerMainViewPresenter)
             container.Register<IMainViewPresenter, IChangePropagator, MoBiMainViewPresenter>(LifeStyle.Singleton);
 
          container.Register<IBuildingBlockExplorerPresenter, IMainViewItemPresenter, BuildingBlockExplorerPresenter>(LifeStyle.Singleton);
diff --git a/src/MoBi.Presentation/Presenter/AbstractParameterBasePresenter.cs b/src/MoBi.Presentation/Presenter/AbstractParameterBasePresenter.cs
index d85a3c4a4..b2a816bca 100644
--- a/src/MoBi.Presentation/Presenter/AbstractParameterBasePresenter.cs
+++ b/src/MoBi.Presentation/Presenter/AbstractParameterBasePresenter.cs
@@ -49,7 +49,7 @@ public virtual IBuildingBlock BuildingBlock
 
       public IFormulaCache FormulaCache => BuildingBlock?.FormulaCache;
 
-      public void SetParamterUnit(IParameterDTO parameterDTO, Unit displayUnit)
+      public void SetParameterUnit(IParameterDTO parameterDTO, Unit displayUnit)
       {
          ExecuteQuantityTaskAction(parameterDTO,
             (p, sim) => _quantityTask.SetQuantityDisplayUnit(p, displayUnit, sim),
@@ -95,9 +95,9 @@ public IEnumerable<FormulaBuilderDTO> GetFormulas()
       }
 
 
-      public IEnumerable<IDimension> GetDimensions()
+      public IReadOnlyList<IDimension> GetDimensions()
       {
-         return _interactionTaskContext.Context.DimensionFactory.Dimensions;
+         return _interactionTaskContext.Context.DimensionFactory.DimensionsSortedByName;
       }
 
       public void SetIsFavorite(IParameterDTO parameterDTO, bool isFavorite)
diff --git a/src/MoBi.Presentation/Presenter/CalculateScaleDivisorsPresenter.cs b/src/MoBi.Presentation/Presenter/CalculateScaleDivisorsPresenter.cs
index 131f63ff3..38527771c 100644
--- a/src/MoBi.Presentation/Presenter/CalculateScaleDivisorsPresenter.cs
+++ b/src/MoBi.Presentation/Presenter/CalculateScaleDivisorsPresenter.cs
@@ -16,6 +16,7 @@
 using OSPSuite.Core.Services;
 using OSPSuite.Presentation.Presenters;
 using OSPSuite.Assets;
+using OSPSuite.Utility.Exceptions;
 
 namespace MoBi.Presentation.Presenter
 {
@@ -136,6 +137,10 @@ public async Task StartScaleDivisorsCalculation()
          {
             /*canceled*/
          }
+         catch (Exception e)
+         {
+            throw new OSPSuiteException(e.ExceptionMessage(addContactSupportInfo:false));
+         }
          finally
          {
             _view.Calculating = false;
diff --git a/src/MoBi.Presentation/Presenter/ChartPresenter.cs b/src/MoBi.Presentation/Presenter/ChartPresenter.cs
index 85139bbf7..6666bbcba 100644
--- a/src/MoBi.Presentation/Presenter/ChartPresenter.cs
+++ b/src/MoBi.Presentation/Presenter/ChartPresenter.cs
@@ -14,6 +14,7 @@
 using OSPSuite.Core.Domain.Data;
 using OSPSuite.Core.Events;
 using OSPSuite.Presentation.Binders;
+using OSPSuite.Presentation.Core;
 using OSPSuite.Presentation.DTO;
 using OSPSuite.Presentation.Extensions;
 using OSPSuite.Presentation.MenuAndBars;
@@ -158,20 +159,20 @@ private void initLayout()
          _chartPresenterContext.EditorLayoutTask.InitFromUserSettings(_chartPresenterContext.EditorAndDisplayPresenter);
       }
 
-      protected void LoadFromTemplate(CurveChartTemplate chartTemplate, bool triggeredManually, bool propogateChartChangeEvent = true)
+      protected void LoadFromTemplate(CurveChartTemplate chartTemplate, bool triggeredManually, bool propagateChartChangeEvent = true)
       {
-         _chartTemplatingTask.InitFromTemplate(_dataRepositoryCache, Chart, editorPresenter, chartTemplate, CurveNameDefinition, triggeredManually, propogateChartChangeEvent);
+         _chartTemplatingTask.InitFromTemplate(_dataRepositoryCache, Chart, editorPresenter, chartTemplate, CurveNameDefinition, triggeredManually, propagateChartChangeEvent);
       }
 
-      protected virtual void OnDragOver(object sender, DragEventArgs e)
+      protected virtual void OnDragOver(object sender, IDragEvent e)
       {
          if (simulationResultsIsBeingDragged(e))
-            e.Effect = CanDropSimulation ? DragDropEffects.Move : DragDropEffects.None;
+            e.Effect = CanDropSimulation ? DragEffect.Move : DragEffect.None;
          else
             _observedDataDragDropBinder.PrepareDrag(e);
       }
 
-      private static bool simulationResultsIsBeingDragged(DragEventArgs e)
+      private static bool simulationResultsIsBeingDragged(IDragEvent e)
       {
          var data = e.Data<IList<ITreeNode>>();
          //do not use null propagation as suggested by resharper
@@ -182,7 +183,7 @@ private static bool simulationResultsIsBeingDragged(DragEventArgs e)
          return data.Count == data.OfType<HistoricalResultsNode>().Count();
       }
 
-      protected virtual void OnDragDrop(object sender, DragEventArgs e)
+      protected virtual void OnDragDrop(object sender, IDragEvent e)
       {
          if (simulationResultsIsBeingDragged(e) && CanDropSimulation)
          {
@@ -236,7 +237,7 @@ public void Show(CurveChart chart, IReadOnlyList<DataRepository> dataRepositorie
             //do not validate template when showing a chart as the chart might well be without curves when initialized for the first time.
             var currentTemplate = defaultTemplate ?? _chartTemplatingTask.TemplateFrom(chart, validateTemplate: false);
             replaceSimulationRepositories(dataRepositories);
-            LoadFromTemplate(currentTemplate, triggeredManually: false, propogateChartChangeEvent: false);
+            LoadFromTemplate(currentTemplate, triggeredManually: false, propagateChartChangeEvent: false);
             addObservedDataIfNeeded(dataRepositories);
          }
          finally
diff --git a/src/MoBi.Presentation/Presenter/EditDistributedParameterPresenter.cs b/src/MoBi.Presentation/Presenter/EditDistributedParameterPresenter.cs
index 5dea1fcf4..23de6ab56 100644
--- a/src/MoBi.Presentation/Presenter/EditDistributedParameterPresenter.cs
+++ b/src/MoBi.Presentation/Presenter/EditDistributedParameterPresenter.cs
@@ -31,7 +31,7 @@ public interface IEditDistributedParameterPresenter : IEditPresenter<IDistribute
       IPresenterWithFormulaCache,
       ICreatePresenter<IDistributedParameter>
    {
-      IEnumerable<IDimension> GetDimensions();
+      IReadOnlyList<IDimension> GetDimensions();
       IDimension PercentDimension { get; }
       IDimension NoDimension { get; }
       void SetPercentile(double newValue);
@@ -94,9 +94,9 @@ public void RenameSubject()
          _editTasks.Rename(_distributedParameter, BuildingBlock);
       }
 
-      public IEnumerable<IDimension> GetDimensions()
+      public IReadOnlyList<IDimension> GetDimensions()
       {
-         return _context.DimensionFactory.Dimensions;
+         return _context.DimensionFactory.DimensionsSortedByName;
       }
 
       public override bool CanClose => _distributedParameter == null || base.CanClose;
diff --git a/src/MoBi.Presentation/Presenter/EditFavoritesPresenter.cs b/src/MoBi.Presentation/Presenter/EditFavoritesPresenter.cs
index c2b27666f..39970cf80 100644
--- a/src/MoBi.Presentation/Presenter/EditFavoritesPresenter.cs
+++ b/src/MoBi.Presentation/Presenter/EditFavoritesPresenter.cs
@@ -91,7 +91,7 @@ private void updateFavorites()
          _editParameterListPresenter.Edit(allFavoritesParameters);
 
          //name always visible
-         _editParameterListPresenter.SetVisibility(PathElement.Name, isVisible: true);
+         _editParameterListPresenter.SetVisibility(PathElementId.Name, isVisible: true);
 
          UpdateSpecialColumnsVisibility();
       }
diff --git a/src/MoBi.Presentation/Presenter/EditFormulaPathListPresenter.cs b/src/MoBi.Presentation/Presenter/EditFormulaPathListPresenter.cs
index 55d8d97e2..90811bf95 100644
--- a/src/MoBi.Presentation/Presenter/EditFormulaPathListPresenter.cs
+++ b/src/MoBi.Presentation/Presenter/EditFormulaPathListPresenter.cs
@@ -54,7 +54,7 @@ public interface IEditFormulaPathListPresenter :
 
       void RemovePath(FormulaUsablePathDTO formulaUsablePathDTO);
 
-      IEnumerable<IDimension> GetDimensions();
+      IReadOnlyList<IDimension> GetDimensions();
 
       /// <summary>
       ///    Clones the path of <paramref name="formulaUsablePathToClone" /> and adds it to the formula with a unique alias
@@ -225,9 +225,9 @@ public void ShowContextMenu(IViewItem viewItem, Point popupLocation)
          contextMenu.Show(View, popupLocation);
       }
 
-      public IEnumerable<IDimension> GetDimensions()
+      public IReadOnlyList<IDimension> GetDimensions()
       {
-         return _context.DimensionFactory.Dimensions;
+         return _context.DimensionFactory.DimensionsSortedByName;
       }
 
       public void Handle(FormulaChangedEvent eventToHandle)
diff --git a/src/MoBi.Presentation/Presenter/EditFormulaPresenter.cs b/src/MoBi.Presentation/Presenter/EditFormulaPresenter.cs
index f87409993..06d62022c 100644
--- a/src/MoBi.Presentation/Presenter/EditFormulaPresenter.cs
+++ b/src/MoBi.Presentation/Presenter/EditFormulaPresenter.cs
@@ -206,7 +206,7 @@ private IDimension formulaDimension
 
       private IDimension rhsDimensionFor(IWithDimension withDimension)
       {
-         return _context.DimensionFactory.RHSDimensionFor(withDimension.Dimension);
+         return _context.DimensionFactory.GetOrAddRHSDimensionFor(withDimension.Dimension);
       }
 
       private void selectFormulaByTypeAndName(Type formulaType, string formulaName)
diff --git a/src/MoBi.Presentation/Presenter/EditObserverBuilderPresenter.cs b/src/MoBi.Presentation/Presenter/EditObserverBuilderPresenter.cs
index 703852348..a928ddc4c 100644
--- a/src/MoBi.Presentation/Presenter/EditObserverBuilderPresenter.cs
+++ b/src/MoBi.Presentation/Presenter/EditObserverBuilderPresenter.cs
@@ -28,7 +28,7 @@ public interface IEditObserverBuilderPresenter : IPresenter<IEditObserverBuilder
       IPresenterWithFormulaCache,
       ICreatePresenter<IObserverBuilder>
    {
-      IEnumerable<IDimension> AllDimensions();
+      IReadOnlyList<IDimension> AllDimensions();
       void UpdateDimension(IDimension newDimension);
    }
 
@@ -83,7 +83,7 @@ public void Edit(TObserverBuilder observerBuilder)
 
       public IBuildingBlock BuildingBlock
       {
-         get { return _buildingBlock; }
+         get => _buildingBlock;
          set
          {
             _buildingBlock = value;
@@ -109,9 +109,9 @@ protected override void FormulaChanged()
 
       protected abstract ObserverBuilderDTO MapFrom(TObserverBuilder observerBuilder);
 
-      public IEnumerable<IDimension> AllDimensions()
+      public IReadOnlyList<IDimension> AllDimensions()
       {
-         return _context.DimensionFactory.Dimensions;
+         return _context.DimensionFactory.DimensionsSortedByName;
       }
 
       public void UpdateDimension(IDimension newDimension)
diff --git a/src/MoBi.Presentation/Presenter/EditOutputSchemaPresenter.cs b/src/MoBi.Presentation/Presenter/EditOutputSchemaPresenter.cs
index 7b7183c1a..8bf6a1633 100644
--- a/src/MoBi.Presentation/Presenter/EditOutputSchemaPresenter.cs
+++ b/src/MoBi.Presentation/Presenter/EditOutputSchemaPresenter.cs
@@ -52,7 +52,7 @@ private void bindToView()
       public void Edit(IMoBiSimulation simulation)
       {
          _simulation = simulation;
-         Edit(_simulation.Settings);
+         Edit(_simulation.SimulationSettings);
       }
 
       public void Edit(ISimulationSettings simulationSettings)
diff --git a/src/MoBi.Presentation/Presenter/EditParameterListPresenter.cs b/src/MoBi.Presentation/Presenter/EditParameterListPresenter.cs
index cef611f52..a688a2739 100644
--- a/src/MoBi.Presentation/Presenter/EditParameterListPresenter.cs
+++ b/src/MoBi.Presentation/Presenter/EditParameterListPresenter.cs
@@ -18,12 +18,13 @@
 
 namespace MoBi.Presentation.Presenter
 {
-   public class EditParameterListPresenter : AbstractParameterBasePresenter<IEditParameterListView, IEditParameterListPresenter>, IEditParameterListPresenter
+   public class EditParameterListPresenter : AbstractParameterBasePresenter<IEditParameterListView, IEditParameterListPresenter>,
+      IEditParameterListPresenter
    {
       private readonly IViewItemContextMenuFactory _viewItemContextMenuFactory;
       private readonly IParameterToParameterDTOMapper _parameterDTOMapper;
-      private IEnumerable<IParameter> _parameters;
       private readonly List<ParameterDTO> _parameterDTOs = new List<ParameterDTO>();
+      public IEnumerable<IParameter> EditedParameters { get; private set; }
 
       public EditParameterListPresenter(
          IEditParameterListView view,
@@ -39,7 +40,7 @@ public EditParameterListPresenter(
          _viewItemContextMenuFactory = viewItemContextMenuFactory;
          _parameterDTOMapper = parameterDTOMapper;
       }
-   
+
       public void ShowContextMenu(IViewItem viewItem, Point popupLocation)
       {
          var contextMenu = _viewItemContextMenuFactory.CreateFor(viewItem, this);
@@ -59,25 +60,24 @@ public void Edit(IEnumerable<IParameter> parameters)
       {
          releaseParameters();
 
-         _parameters = parameters;
-         _parameterDTOs.AddRange(_parameters.MapAllUsing(_parameterDTOMapper).Cast<ParameterDTO>());
+         EditedParameters = parameters;
+         _parameterDTOs.AddRange(EditedParameters.MapAllUsing(_parameterDTOMapper).Cast<ParameterDTO>());
 
          _view.BindTo(_parameterDTOs);
 
-         EnumHelper.AllValuesFor<PathElement>().Each(updateColumnVisibility);
+         EnumHelper.AllValuesFor<PathElementId>().Each(updateColumnVisibility);
       }
 
-      private void updateColumnVisibility(PathElement pathElement)
+      private void updateColumnVisibility(PathElementId pathElement)
       {
          SetVisibility(pathElement, !_parameterDTOs.HasOnlyEmptyValuesAt(pathElement));
       }
 
-      public void SetVisibility(PathElement pathElement, bool isVisible)
+      public void SetVisibility(PathElementId pathElement, bool isVisible)
       {
          View.SetVisibility(pathElement, isVisible);
       }
 
-
       public virtual IReadOnlyList<IParameter> SelectedParameters
       {
          get => ParametersFrom(_view.SelectedParameters).ToList();
@@ -90,8 +90,6 @@ public virtual IReadOnlyList<IParameter> SelectedParameters
          }
       }
 
-      public IEnumerable<IParameter> EditedParameters => _parameters;
-
       public override void ReleaseFrom(IEventPublisher eventPublisher)
       {
          base.ReleaseFrom(eventPublisher);
diff --git a/src/MoBi.Presentation/Presenter/EditParameterListPresenterExtensions.cs b/src/MoBi.Presentation/Presenter/EditParameterListPresenterExtensions.cs
index fd48c66bd..0b1617bd8 100644
--- a/src/MoBi.Presentation/Presenter/EditParameterListPresenterExtensions.cs
+++ b/src/MoBi.Presentation/Presenter/EditParameterListPresenterExtensions.cs
@@ -10,37 +10,37 @@ public static class EditParameterListPresenterExtensions
       public static void ConfigureForReaction(this IEditParameterListPresenter presenter)
       {
          var view = presenter.View;
-         var captions = new Dictionary<PathElement, string> {{PathElement.TopContainer, ObjectTypes.Reaction}};
+         var captions = new Dictionary<PathElementId, string> {{ PathElementId.TopContainer, ObjectTypes.Reaction}};
          view.SetCaptions(captions);
 
-         view.SetVisibility(PathElement.BottomCompartment, isVisible: false);
-         view.SetVisibility(PathElement.Container, isVisible: false);
-         view.SetVisibility(PathElement.Molecule, isVisible: false);
+         view.SetVisibility(PathElementId.BottomCompartment, isVisible: false);
+         view.SetVisibility(PathElementId.Container, isVisible: false);
+         view.SetVisibility(PathElementId.Molecule, isVisible: false);
       }
 
       public static void ConfigureForEvent(this IEditParameterListPresenter presenter)
       {
          var view = presenter.View;
-         view.SetVisibility(PathElement.Molecule, isVisible: false);
+         view.SetVisibility(PathElementId.Molecule, isVisible: false);
       }
 
       public static void ConfigureForMolecule(this IEditParameterListPresenter presenter)
       {
          var view = presenter.View;
-         var captions = new Dictionary<PathElement, string>
+         var captions = new Dictionary<PathElementId, string>
          {
-            {PathElement.TopContainer, AppConstants.Captions.Molecule},
-            {PathElement.Container, $"{ObjectTypes.TransporterMoleculeContainer}/{ObjectTypes.InteractionContainer}"},
-            {PathElement.BottomCompartment, ObjectTypes.ActiveTransport}
+            {PathElementId.TopContainer, AppConstants.Captions.Molecule},
+            {PathElementId.Container, $"{ObjectTypes.TransporterMoleculeContainer}/{ObjectTypes.InteractionContainer}"},
+            {PathElementId.BottomCompartment, ObjectTypes.ActiveTransport}
          };
          view.SetCaptions(captions);
-         view.SetVisibility(PathElement.Molecule, isVisible: false);
+         view.SetVisibility(PathElementId.Molecule, isVisible: false);
       }
 
       public static void ShowNameColumn(this IEditParameterListPresenter presenter)
       {
          var view = presenter.View;
-         view.SetVisibility(PathElement.Name, isVisible: true);
+         view.SetVisibility(PathElementId.Name, isVisible: true);
       }
    }
 }
\ No newline at end of file
diff --git a/src/MoBi.Presentation/Presenter/EditParameterPresenter.cs b/src/MoBi.Presentation/Presenter/EditParameterPresenter.cs
index 5fdb0603f..5f13842cf 100644
--- a/src/MoBi.Presentation/Presenter/EditParameterPresenter.cs
+++ b/src/MoBi.Presentation/Presenter/EditParameterPresenter.cs
@@ -1,13 +1,8 @@
 using System.Collections.Generic;
 using System.Linq;
 using MoBi.Assets;
-using OSPSuite.Core.Commands.Core;
-using OSPSuite.Utility;
-using OSPSuite.Utility.Events;
-using OSPSuite.Utility.Extensions;
 using MoBi.Core.Commands;
 using MoBi.Core.Domain.Model;
-using MoBi.Core.Helper;
 using MoBi.Core.Services;
 using MoBi.Presentation.DTO;
 using MoBi.Presentation.Mappers;
@@ -16,12 +11,16 @@
 using MoBi.Presentation.Tasks.Edit;
 using MoBi.Presentation.Tasks.Interaction;
 using MoBi.Presentation.Views;
+using OSPSuite.Core.Commands.Core;
 using OSPSuite.Core.Domain;
 using OSPSuite.Core.Domain.Builder;
 using OSPSuite.Core.Domain.Formulas;
 using OSPSuite.Core.Domain.UnitSystem;
 using OSPSuite.Core.Services;
 using OSPSuite.Presentation.Presenters;
+using OSPSuite.Utility;
+using OSPSuite.Utility.Events;
+using OSPSuite.Utility.Extensions;
 
 namespace MoBi.Presentation.Presenter
 {
@@ -30,7 +29,7 @@ public interface IEditParameterPresenter : IEditPresenter<IParameter>,
       ICreatePresenter<IParameter>
    {
       void SetUseRHSFormula(bool useRHS);
-      IEnumerable<IDimension> AllDimensions();
+      IReadOnlyList<IDimension> AllDimensions();
       void SetDimension(IDimension dimension);
       IEnumerable<IObjectBase> LocalEntitiesToReference { set; }
       bool CanSetBuildMode { set; }
@@ -74,7 +73,7 @@ public interface IEditParameterPresenter : IEditPresenter<IParameter>,
       void SetName(ParameterDTO parameterDTO, string newName);
 
       /// <summary>
-      /// Build modes that can be used in this use case
+      ///    Build modes that can be used in this use case
       /// </summary>
       IEnumerable<ParameterBuildMode> ParameterBuildModes { get; set; }
 
@@ -101,19 +100,19 @@ public class EditParameterPresenter : AbstractEntityEditPresenter<IEditParameter
       public IEnumerable<ParameterBuildMode> ParameterBuildModes { get; set; }
       public bool WarnOnBuildModeChange { get; set; }
 
-      public EditParameterPresenter(IEditParameterView view, 
-         IEditFormulaPresenter editValueFormulaPresenter, 
+      public EditParameterPresenter(IEditParameterView view,
+         IEditFormulaPresenter editValueFormulaPresenter,
          IParameterToParameterDTOMapper parameterMapper,
-         IEditFormulaPresenter editRhsFormulaPresenter, 
-         IInteractionTaskContext interactionTaskContext, 
-         IEntityTask entityTask, 
-         IGroupRepository groupRepository, 
+         IEditFormulaPresenter editRhsFormulaPresenter,
+         IInteractionTaskContext interactionTaskContext,
+         IEntityTask entityTask,
+         IGroupRepository groupRepository,
          IEditTaskFor<IParameter> editTasks,
-         IInteractionTasksForParameter parameterTask, 
-         IContextSpecificReferencesRetriever contextSpecificReferencesRetriever, 
+         IInteractionTasksForParameter parameterTask,
+         IContextSpecificReferencesRetriever contextSpecificReferencesRetriever,
          IFavoriteTask favoriteTask,
          IEditValueOriginPresenter editValueOriginPresenter
-         )
+      )
          : base(view)
       {
          _editValueFormulaPresenter = editValueFormulaPresenter;
@@ -144,16 +143,6 @@ IEditValueOriginPresenter editValueOriginPresenter
          _editValueOriginPresenter.ShowCaption = false;
       }
 
-      public void SetPropertyValueFromView<TProp>(string propertyName, TProp newValue, TProp oldValue)
-      {
-         if (propertyName.Equals(_parameter.PropertyName(p => p.BuildMode)))
-         {
-            _interactionTaskContext.DialogCreator.MessageBoxInfo(AppConstants.Validation.ChangeBuildModeWarning);
-         }
-
-         AddCommand(new EditObjectBasePropertyInBuildingBlockCommand(propertyName, newValue, oldValue, _parameter, BuildingBlock).Run(_interactionTaskContext.Context));
-      }
-
       public void SetIsFavorite(bool isFavorite)
       {
          _favoriteTask.SetParameterFavorite(_parameter, isFavorite);
@@ -166,15 +155,17 @@ public void RenameParameter()
 
       public void SetDescription(ParameterDTO parameterDTO, string newDescription)
       {
-         AddCommand(_parameterTask.SetDescriptionForParameter(parameterDTO.Parameter, newDescription, BuildingBlock).Run(_interactionTaskContext.Context));
+         AddCommand(_parameterTask.SetDescriptionForParameter(parameterDTO.Parameter, newDescription, BuildingBlock)
+            .Run(_interactionTaskContext.Context));
       }
 
       public void SetBuildMode(ParameterDTO parameterDTO, ParameterBuildMode newBuildMode)
       {
-         if (WarnOnBuildModeChange) 
+         if (WarnOnBuildModeChange)
             _interactionTaskContext.DialogCreator.MessageBoxInfo(AppConstants.Validation.ChangeBuildModeWarning);
 
-         AddCommand(_parameterTask.SetBuildModeForParameter(parameterDTO.Parameter, newBuildMode, BuildingBlock).Run(_interactionTaskContext.Context));
+         AddCommand(_parameterTask.SetBuildModeForParameter(parameterDTO.Parameter, newBuildMode, BuildingBlock)
+            .Run(_interactionTaskContext.Context));
       }
 
       public void SetName(ParameterDTO parameterDTO, string newName)
@@ -212,7 +203,8 @@ public override void Edit(IParameter parameter, IEnumerable<IObjectBase> existin
       {
          _parameter = parameter;
          _editValueFormulaPresenter.Init(_parameter, BuildingBlock);
-         _editValueFormulaPresenter.ReferencePresenter.Init(_contextSpecificReferencesRetriever.RetrieveLocalReferencePoint(parameter), _contextSpecificReferencesRetriever.RetrieveFor(_parameter, BuildingBlock), _parameter);
+         _editValueFormulaPresenter.ReferencePresenter.Init(_contextSpecificReferencesRetriever.RetrieveLocalReferencePoint(parameter),
+            _contextSpecificReferencesRetriever.RetrieveFor(_parameter, BuildingBlock), _parameter);
          _editValueOriginPresenter.Edit(parameter);
          if (hasRHS(parameter))
             initRHSPresenter();
@@ -236,7 +228,8 @@ private static bool hasRHS(IParameter parameter)
       private void initRHSPresenter()
       {
          _editRHSFormulaPresenter.Init(_parameter, BuildingBlock);
-         _editRHSFormulaPresenter.ReferencePresenter.Init(_contextSpecificReferencesRetriever.RetrieveLocalReferencePoint(_parameter), _contextSpecificReferencesRetriever.RetrieveFor(_parameter, BuildingBlock), _parameter);
+         _editRHSFormulaPresenter.ReferencePresenter.Init(_contextSpecificReferencesRetriever.RetrieveLocalReferencePoint(_parameter),
+            _contextSpecificReferencesRetriever.RetrieveFor(_parameter, BuildingBlock), _parameter);
       }
 
       public override object Subject => _parameter;
@@ -294,14 +287,11 @@ public void SetGroup(IGroup group)
          _parameterDTO.Group = group;
       }
 
-      public string DisplayFor(IGroup group)
-      {
-         return group.FullName;
-      }
+      public string DisplayFor(IGroup group) => @group.FullName;
 
-      public IEnumerable<IDimension> AllDimensions()
+      public IReadOnlyList<IDimension> AllDimensions()
       {
-         return _interactionTaskContext.Context.DimensionFactory.Dimensions;
+         return _interactionTaskContext.Context.DimensionFactory.DimensionsSortedByName;
       }
 
       private void addCommandToRun(ICommand<IMoBiContext> command)
@@ -331,6 +321,5 @@ public override bool CanClose
             return !_view.HasError && _editValueFormulaPresenter.CanClose;
          }
       }
-
    }
 }
\ No newline at end of file
diff --git a/src/MoBi.Presentation/Presenter/EditParametersInContainerPresenter.cs b/src/MoBi.Presentation/Presenter/EditParametersInContainerPresenter.cs
index 2875928ef..9924e14cb 100644
--- a/src/MoBi.Presentation/Presenter/EditParametersInContainerPresenter.cs
+++ b/src/MoBi.Presentation/Presenter/EditParametersInContainerPresenter.cs
@@ -104,7 +104,6 @@ public void Edit(IContainer container)
          _view.ParentName = container.Name;
          createParameterCache(_getParametersFunc(container));
          showParameters();
-         setupEditPresenter(_parameters.FirstOrDefault());
       }
 
       public override void ReleaseFrom(IEventPublisher eventPublisher)
@@ -162,8 +161,10 @@ private ParameterDTO dtoFor(IParameter parameter)
 
       private void showParameters()
       {
-         var parametersToShowDTO = _allParametersDTO.Where(shouldShowParameter);
+         var parametersToShowDTO = _allParametersDTO.Where(shouldShowParameter).ToList();
          _view.BindTo(parametersToShowDTO);
+         setupEditPresenter(parametersToShowDTO.FirstOrDefault()?.Parameter);
+
       }
 
       private bool shouldShowParameter(ParameterDTO parameterDTO)
diff --git a/src/MoBi.Presentation/Presenter/EditSimulationPresenter.cs b/src/MoBi.Presentation/Presenter/EditSimulationPresenter.cs
index 87370363b..a63bad04c 100644
--- a/src/MoBi.Presentation/Presenter/EditSimulationPresenter.cs
+++ b/src/MoBi.Presentation/Presenter/EditSimulationPresenter.cs
@@ -12,8 +12,8 @@
 using OSPSuite.Core.Chart;
 using OSPSuite.Core.Domain;
 using OSPSuite.Core.Domain.Data;
+using OSPSuite.Core.Services;
 using OSPSuite.Presentation.Presenters;
-using OSPSuite.Presentation.Services;
 using OSPSuite.Utility.Collections;
 using OSPSuite.Utility.Events;
 using OSPSuite.Utility.Extensions;
diff --git a/src/MoBi.Presentation/Presenter/EditSolverSettingsPresenter.cs b/src/MoBi.Presentation/Presenter/EditSolverSettingsPresenter.cs
index ce7f85ac7..7d323cfd1 100644
--- a/src/MoBi.Presentation/Presenter/EditSolverSettingsPresenter.cs
+++ b/src/MoBi.Presentation/Presenter/EditSolverSettingsPresenter.cs
@@ -65,7 +65,7 @@ private IMoBiCommand createEditCommandFor(string name, object newValue, object o
       public void Edit(IMoBiSimulation simulation)
       {
          _simulation = simulation;
-         Edit(_simulation.Settings);
+         Edit(_simulation.SimulationSettings);
       }
 
       public void Edit(ISimulationSettings simulationSettings)
diff --git a/src/MoBi.Presentation/Presenter/EditSpatialStructurePresenter.cs b/src/MoBi.Presentation/Presenter/EditSpatialStructurePresenter.cs
index 80846af17..2ff9b9119 100644
--- a/src/MoBi.Presentation/Presenter/EditSpatialStructurePresenter.cs
+++ b/src/MoBi.Presentation/Presenter/EditSpatialStructurePresenter.cs
@@ -7,6 +7,7 @@
 using MoBi.Presentation.Presenter.SpaceDiagram;
 using MoBi.Presentation.Views;
 using OSPSuite.Core.Domain;
+using OSPSuite.Core.Services;
 using OSPSuite.Presentation.Presenters;
 using OSPSuite.Presentation.Services;
 using OSPSuite.Presentation.Views;
diff --git a/src/MoBi.Presentation/Presenter/HierarchicalSimulationPresenter.cs b/src/MoBi.Presentation/Presenter/HierarchicalSimulationPresenter.cs
index 707b4648c..74e7920bf 100644
--- a/src/MoBi.Presentation/Presenter/HierarchicalSimulationPresenter.cs
+++ b/src/MoBi.Presentation/Presenter/HierarchicalSimulationPresenter.cs
@@ -73,7 +73,7 @@ public void Edit(IMoBiSimulation simulation)
          _view.AddNode(_favoritesNode);
          _view.AddNode(_userDefinedNode);
 
-         var roots = new List<IObjectBaseDTO> {_simulationSettingsMapper.MapFrom(simulation.Settings)};
+         var roots = new List<IObjectBaseDTO> {_simulationSettingsMapper.MapFrom(simulation.SimulationSettings) };
          roots.AddRange(rootContainers());
          _view.Show(roots);
 
diff --git a/src/MoBi.Presentation/Presenter/IEditParameterListPresenter.cs b/src/MoBi.Presentation/Presenter/IEditParameterListPresenter.cs
index 953369e2f..605e7a7a2 100644
--- a/src/MoBi.Presentation/Presenter/IEditParameterListPresenter.cs
+++ b/src/MoBi.Presentation/Presenter/IEditParameterListPresenter.cs
@@ -1,5 +1,4 @@
-using System.Collections;
-using System.Collections.Generic;
+using System.Collections.Generic;
 using MoBi.Presentation.DTO;
 using MoBi.Presentation.Views;
 using OSPSuite.Core.Domain;
@@ -12,7 +11,7 @@ public interface IEditParameterListPresenter : IParameterPresenter, IPresenterWi
    {
       void GoTo(ParameterDTO parameterDTO);
       void Edit(IEnumerable<IParameter> parameters);
-      void SetVisibility(PathElement pathElement, bool isVisible);
+      void SetVisibility(PathElementId pathElement, bool isVisible);
       IEnumerable<IParameter> EditedParameters { get; }
       IReadOnlyList<IParameter> SelectedParameters { get; set; }
    }
diff --git a/src/MoBi.Presentation/Presenter/IParameterPresenter.cs b/src/MoBi.Presentation/Presenter/IParameterPresenter.cs
index 4c7f1d687..df9b76cae 100644
--- a/src/MoBi.Presentation/Presenter/IParameterPresenter.cs
+++ b/src/MoBi.Presentation/Presenter/IParameterPresenter.cs
@@ -8,11 +8,11 @@ namespace MoBi.Presentation.Presenter
 {
    public interface IParameterPresenter : IPresenterWithFormulaCache, ICommandCollectorPresenter
    {
-      void SetParamterUnit(IParameterDTO parameterDTO, Unit displayUnit);
+      void SetParameterUnit(IParameterDTO parameterDTO, Unit displayUnit);
       bool IsFixedValue(IParameterDTO parameterDTO);
       void OnParameterValueSet(IParameterDTO parameterDTO, double valueInGuiUnit);
       void OnParameterValueOriginSet(IParameterDTO parameterDTO, ValueOrigin valueOrigin);
-      IEnumerable<IDimension> GetDimensions();
+      IReadOnlyList<IDimension> GetDimensions();
       void SetIsFavorite(IParameterDTO parameterDTO, bool isFavorite);
       void ResetValueFor(IParameterDTO parameterDTO);
    }
diff --git a/src/MoBi.Presentation/Presenter/Main/MenuAndToolBarPresenter.cs b/src/MoBi.Presentation/Presenter/Main/MenuAndToolBarPresenter.cs
index 5785b4cb6..14e91c156 100644
--- a/src/MoBi.Presentation/Presenter/Main/MenuAndToolBarPresenter.cs
+++ b/src/MoBi.Presentation/Presenter/Main/MenuAndToolBarPresenter.cs
@@ -14,12 +14,12 @@
 using OSPSuite.Core.Domain.SensitivityAnalyses;
 using OSPSuite.Core.Events;
 using OSPSuite.Core.Journal;
-using OSPSuite.Presentation.Events;
 using OSPSuite.Presentation.Presenters.Main;
 using OSPSuite.Presentation.Repositories;
 using OSPSuite.Presentation.Services;
 using OSPSuite.Presentation.Views;
 using OSPSuite.Assets;
+using OSPSuite.Presentation.Presenters.Events;
 
 namespace MoBi.Presentation.Presenter.Main
 {
@@ -93,8 +93,8 @@ protected override void AddRibbonPages()
 
          initializeDynamicPages();
 
-         _view.AddQuickAcccessButton(_menuBarItemRepository[MenuBarItemIds.OpenProject]);
-         _view.AddQuickAcccessButton(_menuBarItemRepository[MenuBarItemIds.SaveProject]);
+         _view.AddQuickAccessButton(_menuBarItemRepository[MenuBarItemIds.OpenProject]);
+         _view.AddQuickAccessButton(_menuBarItemRepository[MenuBarItemIds.SaveProject]);
          _view.AddPageHeaderItemLinks(_menuBarItemRepository[MenuBarItemIds.Help]);
       }
 
diff --git a/src/MoBi.Presentation/Presenter/MoBiMainViewPresenter.cs b/src/MoBi.Presentation/Presenter/MoBiMainViewPresenter.cs
index 95d8e7777..8e9cbc369 100644
--- a/src/MoBi.Presentation/Presenter/MoBiMainViewPresenter.cs
+++ b/src/MoBi.Presentation/Presenter/MoBiMainViewPresenter.cs
@@ -1,4 +1,3 @@
-using Castle.Core.Configuration;
 using MoBi.Assets;
 using MoBi.Core;
 using OSPSuite.TeXReporting.Events;
diff --git a/src/MoBi.Presentation/Presenter/ObjectPathCreatorAtEvent.cs b/src/MoBi.Presentation/Presenter/ObjectPathCreatorAtEvent.cs
index 91fa95dd2..5edfc01ec 100644
--- a/src/MoBi.Presentation/Presenter/ObjectPathCreatorAtEvent.cs
+++ b/src/MoBi.Presentation/Presenter/ObjectPathCreatorAtEvent.cs
@@ -74,7 +74,7 @@ protected override IFormulaUsablePath CreateRelativePath(IFormulaUsable formulaU
                else
                {
                   //Molecule replace With Amount
-                  path = CreateFormulaUsablePathFrom(new[] {ObjectPath.PARENT_CONTAINER, formulaUsable.Name}, formulaUsable.Name, Constants.Dimension.AMOUNT);
+                  path = CreateFormulaUsablePathFrom(new[] {ObjectPath.PARENT_CONTAINER, formulaUsable.Name}, formulaUsable.Name, Constants.Dimension.MOLAR_AMOUNT);
                }
                correctPath(path, refObject as IContainer);
             }
diff --git a/src/MoBi.Presentation/Presenter/ObjectPathCreatorAtTransport.cs b/src/MoBi.Presentation/Presenter/ObjectPathCreatorAtTransport.cs
index d48d8dc79..b4a92e785 100644
--- a/src/MoBi.Presentation/Presenter/ObjectPathCreatorAtTransport.cs
+++ b/src/MoBi.Presentation/Presenter/ObjectPathCreatorAtTransport.cs
@@ -60,7 +60,7 @@ public override ReferenceDTO CreateMoleculePath(DummyMoleculeContainerDTO dtoObj
 
          return new ReferenceDTO
          {
-            Path = CreateFormulaUsablePathFrom(new[] {firstPathElemnt, moleculeElement}, AppConstants.AmountAlias, Constants.Dimension.AMOUNT)
+            Path = CreateFormulaUsablePathFrom(new[] {firstPathElemnt, moleculeElement}, AppConstants.AmountAlias, Constants.Dimension.MOLAR_AMOUNT)
          };
       }
 
diff --git a/src/MoBi.Presentation/Presenter/ObjectPathCreatorBase.cs b/src/MoBi.Presentation/Presenter/ObjectPathCreatorBase.cs
index 7cb000cac..f212df660 100644
--- a/src/MoBi.Presentation/Presenter/ObjectPathCreatorBase.cs
+++ b/src/MoBi.Presentation/Presenter/ObjectPathCreatorBase.cs
@@ -173,7 +173,7 @@ public virtual ReferenceDTO CreateMoleculePath(DummyMoleculeContainerDTO dtoObje
          }
 
          path.Alias = _aliasCreator.CreateAliasFrom(dtoObjectBase.Name);
-         path.Dimension = _context.DimensionFactory.Dimension(Constants.Dimension.AMOUNT);
+         path.Dimension = _context.DimensionFactory.Dimension(Constants.Dimension.MOLAR_AMOUNT);
          path.Add(dtoObjectBase.Name);
 
          return new ReferenceDTO {Path = path};
@@ -183,7 +183,7 @@ private ReferenceDTO createMoleculeReference()
       {
          return new ReferenceDTO
          {
-            Path = CreateFormulaUsablePathFrom(new [] { ObjectPath.PARENT_CONTAINER }, AppConstants.AmountAlias, Constants.Dimension.AMOUNT)
+            Path = CreateFormulaUsablePathFrom(new [] { ObjectPath.PARENT_CONTAINER }, AppConstants.AmountAlias, Constants.Dimension.MOLAR_AMOUNT)
          };
       }
 
diff --git a/src/MoBi.Presentation/Presenter/ObserverBuilderListPresenter.cs b/src/MoBi.Presentation/Presenter/ObserverBuilderListPresenter.cs
index 490809345..1e3fcc41c 100644
--- a/src/MoBi.Presentation/Presenter/ObserverBuilderListPresenter.cs
+++ b/src/MoBi.Presentation/Presenter/ObserverBuilderListPresenter.cs
@@ -30,7 +30,7 @@ public interface IObserverBuilderListPresenter : IPresenterWithContextMenu<IView
       IPresenterWithFormulaCache
    {
       void SetFormula(ObserverBuilderDTO dtoObserverBuilder, FormulaBuilderDTO newValue, FormulaBuilderDTO oldValue);
-      IEnumerable<IDimension> GetDimensions();
+      IReadOnlyList<IDimension> GetDimensions();
       void SetPropertyValueFromViewFor<T>(IObjectBaseDTO dtoObjectBase, string propertyName, T newValue, T oldValue);
       IEditObserverBuildingBlockPresenter Parent { get; set; }
       void Select(ObserverBuilderDTO dto);
@@ -72,10 +72,7 @@ public IEnumerable<FormulaBuilderDTO> GetFormulas()
 
       public IBuildingBlock BuildingBlock { get; set; }
 
-      public IFormulaCache FormulaCache
-      {
-         get { return BuildingBlock.FormulaCache; }
-      }
+      public IFormulaCache FormulaCache => BuildingBlock.FormulaCache;
 
       public void SetFormula(ObserverBuilderDTO dtoObserverBuilder, FormulaBuilderDTO newValue, FormulaBuilderDTO oldValue)
       {
@@ -85,10 +82,7 @@ public void SetFormula(ObserverBuilderDTO dtoObserverBuilder, FormulaBuilderDTO
          AddCommand(new EditObjectBasePropertyInBuildingBlockCommand("Formula", newFormula, oldFormula, observerBuilder, BuildingBlock).Run(_context)); //<IFormula>
       }
 
-      public IEnumerable<IDimension> GetDimensions()
-      {
-         return _dimensionFactory.Dimensions;
-      }
+      public IReadOnlyList<IDimension> GetDimensions() => _dimensionFactory.DimensionsSortedByName;
 
       public void SetPropertyValueFromViewFor<T>(IObjectBaseDTO dtoObserverBuilder, string propertyName, T newValue, T oldValue)
       {
diff --git a/src/MoBi.Presentation/Presenter/SolverMessagePresenter.cs b/src/MoBi.Presentation/Presenter/SolverMessagePresenter.cs
index 6214af368..e1d490d34 100644
--- a/src/MoBi.Presentation/Presenter/SolverMessagePresenter.cs
+++ b/src/MoBi.Presentation/Presenter/SolverMessagePresenter.cs
@@ -1,8 +1,8 @@
 using System.Collections.Generic;
 using MoBi.Assets;
 using MoBi.Presentation.Views;
-using OSPSuite.Core.Domain;
 using OSPSuite.Presentation.Presenters;
+using OSPSuite.SimModel;
 
 namespace MoBi.Presentation.Presenter
 {
diff --git a/src/MoBi.Presentation/Properties/AssemblyInfo.cs b/src/MoBi.Presentation/Properties/AssemblyInfo.cs
deleted file mode 100644
index be02b92fb..000000000
--- a/src/MoBi.Presentation/Properties/AssemblyInfo.cs
+++ /dev/null
@@ -1,7 +0,0 @@
-using System.Reflection;
-
-// General Information about an assembly is controlled through the following 
-// set of attributes. Change these attribute values to modify the information
-// associated with an assembly.
-
-[assembly: AssemblyTitle("MoBiPresentation")]
diff --git a/src/MoBi.Presentation/Repositories/MenuBarItemRepository.cs b/src/MoBi.Presentation/Repositories/MenuBarItemRepository.cs
index 5e308fa6e..ba8043645 100644
--- a/src/MoBi.Presentation/Repositories/MenuBarItemRepository.cs
+++ b/src/MoBi.Presentation/Repositories/MenuBarItemRepository.cs
@@ -13,8 +13,8 @@
 using OSPSuite.Presentation.Presenters.ContextMenus;
 using OSPSuite.Presentation.UICommands;
 using OSPSuite.Assets;
+using Keys = OSPSuite.Presentation.Core.Keys;
 using ToolTips = MoBi.Assets.ToolTips;
-
 namespace MoBi.Presentation.Repositories
 {
    public class MenuBarItemRepository : OSPSuite.Presentation.Repositories.MenuBarItemRepository
@@ -504,7 +504,7 @@ protected override IEnumerable<IMenuBarItem> AllMenuBarItems()
          yield return ParameterIdentificationMenuBarButtons.StopParameterIdentification(MenuBarItemIds.StopParameterIdentification);
          yield return ParameterIdentificationMenuBarButtons.TimeProfileParameterIdentification(MenuBarItemIds.TimeProfileParameterIdentification);
          yield return ParameterIdentificationMenuBarButtons.PredictedVsObservedParameterIdentification(MenuBarItemIds.PredictedVsObservedParameterIdentification);
-         yield return ParameterIdentificationMenuBarButtons.ResidualsVsTimeParameterIdentifcation(MenuBarItemIds.ResidualsVsTimeParameterIdentification);
+         yield return ParameterIdentificationMenuBarButtons.ResidualsVsTimeParameterIdentification(MenuBarItemIds.ResidualsVsTimeParameterIdentification);
          yield return ParameterIdentificationMenuBarButtons.ResidualHistogramParameterIdentification(MenuBarItemIds.ResidualHistogramParameterIdentification);
          yield return ParameterIdentificationMenuBarButtons.CorrelationMatrixParameterIdentification(MenuBarItemIds.CorrelationMatrixParameterIdentification);
          yield return ParameterIdentificationMenuBarButtons.CovarianceMatrixParameterIdentification(MenuBarItemIds.CovarianceMatrixParameterIdentification);
diff --git a/src/MoBi.Presentation/Serialization/Xml/Serializer/MergeConflictViewSettingsXmlSerializer.cs b/src/MoBi.Presentation/Serialization/Xml/Serializer/MergeConflictViewSettingsXmlSerializer.cs
index 2a5c7f34c..bf9d6549c 100644
--- a/src/MoBi.Presentation/Serialization/Xml/Serializer/MergeConflictViewSettingsXmlSerializer.cs
+++ b/src/MoBi.Presentation/Serialization/Xml/Serializer/MergeConflictViewSettingsXmlSerializer.cs
@@ -1,4 +1,3 @@
-
 using OSPSuite.Presentation.Serialization;
 using MergeConflictViewSettings = MoBi.Presentation.Settings.MergeConflictViewSettings;
 
diff --git a/src/MoBi.Presentation/Serialization/Xml/Serializer/MoBiXmlSerializerRepository.cs b/src/MoBi.Presentation/Serialization/Xml/Serializer/MoBiXmlSerializerRepository.cs
index e61e393b1..b4bf76259 100644
--- a/src/MoBi.Presentation/Serialization/Xml/Serializer/MoBiXmlSerializerRepository.cs
+++ b/src/MoBi.Presentation/Serialization/Xml/Serializer/MoBiXmlSerializerRepository.cs
@@ -4,6 +4,8 @@
 using OSPSuite.Core.Serialization.Xml;
 using OSPSuite.Presentation.Serialization;
 using OSPSuite.Presentation.Serialization.Extensions;
+//using OSPSuite.Presentation.Serialization;
+//using OSPSuite.Presentation.Serialization.Extensions;
 using OSPSuite.Serializer;
 using OSPSuite.Serializer.Attributes;
 
diff --git a/src/MoBi.Engine/Tasks/DimensionValidator.cs b/src/MoBi.Presentation/Tasks/DimensionValidator.cs
similarity index 64%
rename from src/MoBi.Engine/Tasks/DimensionValidator.cs
rename to src/MoBi.Presentation/Tasks/DimensionValidator.cs
index 07a32aba3..7e2a831cd 100644
--- a/src/MoBi.Engine/Tasks/DimensionValidator.cs
+++ b/src/MoBi.Presentation/Tasks/DimensionValidator.cs
@@ -4,23 +4,20 @@
 using System.Threading.Tasks;
 using MoBi.Assets;
 using MoBi.Core.Domain.Services;
-using MoBi.Engine.Extensions;
+using MoBi.Core.Extensions;
 using MoBi.Presentation.Settings;
 using OSPSuite.Core.Domain;
 using OSPSuite.Core.Domain.Builder;
 using OSPSuite.Core.Domain.Formulas;
 using OSPSuite.Core.Domain.UnitSystem;
-using OSPSuite.Core.Extensions;
 using OSPSuite.FuncParser;
 using OSPSuite.Utility.Extensions;
-using static MoBi.Assets.AppConstants.Parameters;
-using static MoBi.Assets.AppConstants.DimensionNames;
 
-namespace MoBi.Engine.Tasks
+namespace MoBi.Presentation.Tasks
 {
    public class DimensionValidator : IDimensionValidator
    {
-      private readonly IDimensionParser _dimensionParser;
+      private readonly DimensionParser _dimensionParser;
       private readonly IObjectPathFactory _objectPathFactory;
       private readonly IUserSettings _userSettings;
       private bool _checkDimensions;
@@ -29,35 +26,35 @@ public class DimensionValidator : IDimensionValidator
       private readonly IDictionary<string, string> _hiddenNotifications;
       private bool _checkRules;
 
-      public DimensionValidator(IDimensionParser dimensionParser, IObjectPathFactory objectPathFactory, IUserSettings userSettings)
+      public DimensionValidator(DimensionParser dimensionParser, IObjectPathFactory objectPathFactory, IUserSettings userSettings)
       {
          _dimensionParser = dimensionParser;
          _objectPathFactory = objectPathFactory;
          _userSettings = userSettings;
          _hiddenNotifications = new Dictionary<string, string>
          {
-            {SURFACE_AREA_INTERSTITIAL_INTRACELLULAR, dimensionAreaMessage},
-            {BSA, dimensionAreaMessage},
-            {PERMEABILITY, dimensionVelocityMessage},
-            {SPECIFIC_INTESTINAL_PERMEABILITY_TRANSCELLULAR, dimensionVelocityMessage},
-            {RADIUS_SOLUTE, dimensionValidationMessage(LENGTH)},
-            {SECRETION_OF_LIQUID, dimensionFlowMessage},
+            {AppConstants.Parameters.SURFACE_AREA_INTERSTITIAL_INTRACELLULAR, dimensionAreaMessage},
+            {AppConstants.Parameters.BSA, dimensionAreaMessage},
+            {AppConstants.Parameters.PERMEABILITY, dimensionVelocityMessage},
+            {AppConstants.Parameters.SPECIFIC_INTESTINAL_PERMEABILITY_TRANSCELLULAR, dimensionVelocityMessage},
+            {AppConstants.Parameters.RADIUS_SOLUTE, dimensionValidationMessage(AppConstants.DimensionNames.LENGTH)},
+            {AppConstants.Parameters.SECRETION_OF_LIQUID, dimensionFlowMessage},
             {Constants.Parameters.VOLUME, $"Organism|Saliva|Volume' {dimensionValidationMessage(Constants.Dimension.VOLUME)}"},
-            {RELEASE_RATE_OF_TABLET, dimensionValidationMessage(Constants.Dimension.AMOUNT_PER_TIME)},
-            {V_MAX, dimensionValidationMessage(Constants.Dimension.MOLAR_CONCENTRATION_PER_TIME)},
-            {LYMPH_FLOW_RATE, dimensionFlowMessage},
-            {LYMPH_FLOW_RATE_INCL_MUCOSA, dimensionFlowMessage},
-            {FLUID_RECIRCULATION_FLOW_RATE, dimensionFlowMessage},
-            {FLUID_RECIRCULATION_FLOW_RATE_INCL_MUCOSA, dimensionFlowMessage},
-            {CALCULATED_SPECIFIC_INTESTINAL_PERMEABILITY_TRANSCELLULAR, dimensionVelocityMessage},
-            {EFFECTIVE_MOLECULAR_WEIGHT, "Arguments of MINUS-function must have the same dimension (Formula: MW - F * 0.000000017 - Cl * 0.000000022 - Br * 0.000000062 - I * 0.000000098)"}
+            {AppConstants.Parameters.RELEASE_RATE_OF_TABLET, dimensionValidationMessage(Constants.Dimension.AMOUNT_PER_TIME)},
+            {AppConstants.Parameters.V_MAX, dimensionValidationMessage(Constants.Dimension.MOLAR_CONCENTRATION_PER_TIME)},
+            {AppConstants.Parameters.LYMPH_FLOW_RATE, dimensionFlowMessage},
+            {AppConstants.Parameters.LYMPH_FLOW_RATE_INCL_MUCOSA, dimensionFlowMessage},
+            {AppConstants.Parameters.FLUID_RECIRCULATION_FLOW_RATE, dimensionFlowMessage},
+            {AppConstants.Parameters.FLUID_RECIRCULATION_FLOW_RATE_INCL_MUCOSA, dimensionFlowMessage},
+            {AppConstants.Parameters.CALCULATED_SPECIFIC_INTESTINAL_PERMEABILITY_TRANSCELLULAR, dimensionVelocityMessage},
+            {AppConstants.Parameters.EFFECTIVE_MOLECULAR_WEIGHT, "Arguments of MINUS-function must have the same dimension (Formula: MW - F * 0.000000017 - Cl * 0.000000022 - Br * 0.000000062 - I * 0.000000098)"}
          };
       }
 
       private static string dimensionValidationMessage(string dimensionName) => AppConstants.Validation.DoesNotEvaluateTo(dimensionName);
-      private static string dimensionFlowMessage { get; } = AppConstants.Validation.DoesNotEvaluateTo(FLOW);
-      private static string dimensionVelocityMessage { get; } = AppConstants.Validation.DoesNotEvaluateTo(VELOCITY);
-      private static string dimensionAreaMessage { get; } = AppConstants.Validation.DoesNotEvaluateTo(AREA);
+      private static string dimensionFlowMessage { get; } = AppConstants.Validation.DoesNotEvaluateTo(AppConstants.DimensionNames.FLOW);
+      private static string dimensionVelocityMessage { get; } = AppConstants.Validation.DoesNotEvaluateTo(AppConstants.DimensionNames.VELOCITY);
+      private static string dimensionAreaMessage { get; } = AppConstants.Validation.DoesNotEvaluateTo(AppConstants.DimensionNames.AREA);
 
       public Task<ValidationResult> Validate(IContainer container, IBuildConfiguration buildConfiguration) => Validate(new[] {container}, buildConfiguration);
 
@@ -137,13 +134,13 @@ private void checkRHSFormula(IParameter parameter, string displayPath)
       private void addNotification(NotificationType notificationType, IObjectBase entityToValidate, string notification)
       {
          var builder = _buildConfiguration.BuilderFor(entityToValidate);
-         if (!shouldShowNotifiction(entityToValidate, notification))
+         if (!shouldShowNotification(entityToValidate, notification))
             return;
 
          _result.AddMessage(notificationType, builder, notification);
       }
 
-      private bool shouldShowNotifiction(IObjectBase entityToValidate, string notification)
+      private bool shouldShowNotification(IObjectBase entityToValidate, string notification)
       {
          if (_userSettings.ShowPKSimDimensionProblemWarnings)
             return true;
@@ -170,7 +167,7 @@ private void checkExplicitFormula(IUsingFormula entityUsingFormula, string displ
       {
          if (explicitFormula == null) return;
 
-         var dimensionInfos = new List<IQuantityDimensionInfo>();
+         var dimensionInfos = new List<QuantityDimensionInformation>();
          if (isDoubleString(explicitFormula.FormulaString))
             return;
 
@@ -180,45 +177,45 @@ private void checkExplicitFormula(IUsingFormula entityUsingFormula, string displ
             if (!Equals(objectReference.Object.Dimension, pathDim))
                addWarning(entityUsingFormula, AppConstants.Validation.ReferenceDimensionMissmatch(displayPath, objectReference, pathDim));
 
-            dimensionInfos.Add(new QuantityDimensionInfo(objectReference.Alias, createDimensionInfoFromBaseRepresentation(objectReference.Object.Dimension.BaseRepresentation)));
+            dimensionInfos.Add(new QuantityDimensionInformation(objectReference.Alias, createDimensionInfoFromBaseRepresentation(objectReference.Object.Dimension.BaseRepresentation)));
          }
 
-         IFuncParserErrorData ed = new FuncParserErrorData();
-         var verifyDimension = _dimensionParser.GetDimensionInfoFor(explicitFormula.FormulaString, dimensionInfos, ed);
+         var (dimInfo, parseSuccess, calculateDimensionSuccess, errorMessage ) = _dimensionParser.GetDimensionInformationFor(explicitFormula.FormulaString, dimensionInfos);
 
-         if (!ed.ErrorNumber.Equals(errNumber.err_OK))
+         if (!parseSuccess)
          {
-            //ignore some dimension check errors.
-            //Reason: some formulas are written so that dimension exponents cannot be calculated, e.g.
-            //x^y where y is not dimensionless. 
-            //
-            //In this case, err_CANNOTCALC_DIMENSION is returned. 
-            //In all other cases, generate error or warning, depending on the error number returned
-
-            if (ed.ErrorNumber != errNumber.err_CANNOTCALC_DIMENSION || (_userSettings.ShowCannotCalcErrors && ed.ErrorNumber == errNumber.err_CANNOTCALC_DIMENSION))
-            {
-               var notificationType = ed.ErrorNumber.IsOneOf(errNumber.err_DIMENSION, errNumber.err_CANNOTCALC_DIMENSION)
-                  ? NotificationType.Warning
-                  : NotificationType.Error;
+            addNotification(NotificationType.Error, entityUsingFormula, errorMessage);
+            return;
+         }
+
 
-               addNotification(notificationType, entityUsingFormula, ed.Description);
+         if (calculateDimensionSuccess)
+         {
+            if (!dimInfo.AreEquals(createDimensionInfoFromBaseRepresentation(baseDimensionRepresentation)))
+            {
+               addWarning(entityUsingFormula, AppConstants.Validation.FormulaDimensionMismatch(displayPath, explicitFormula.Dimension.Name));
             }
+
+            return;
          }
 
-         else if (!verifyDimension.AreEquals(createDimensionInfoFromBaseRepresentation(baseDimensionRepresentation)))
+         //ignore some dimension check errors.
+         //Reason: some formulas are written so that dimension exponents cannot be calculated, e.g.
+         //x^y where y is not dimensionless. 
+         if (_userSettings.ShowCannotCalcErrors)
          {
-            addWarning(entityUsingFormula, AppConstants.Validation.FormulaDimensionMismatch(displayPath, explicitFormula.Dimension.Name));
+            addWarning(entityUsingFormula, errorMessage);
          }
       }
 
-      private bool isDoubleString(string stringTocheck)
+      private bool isDoubleString(string stringToCheck)
       {
-         return double.TryParse(stringTocheck, out double value);
+         return double.TryParse(stringToCheck, out _);
       }
 
-      private DimensionInfo createDimensionInfoFromBaseRepresentation(BaseDimensionRepresentation baseRepresentation)
+      private DimensionInformation createDimensionInfoFromBaseRepresentation(BaseDimensionRepresentation baseRepresentation)
       {
-         return new DimensionInfo(baseRepresentation.LengthExponent,
+         return new DimensionInformation(baseRepresentation.LengthExponent,
             baseRepresentation.MassExponent,
             baseRepresentation.TimeExponent,
             baseRepresentation.ElectricCurrentExponent,
diff --git a/src/MoBi.Presentation/Tasks/Edit/EditTasksForSimulation.cs b/src/MoBi.Presentation/Tasks/Edit/EditTasksForSimulation.cs
index 6de37468b..a0da762ad 100644
--- a/src/MoBi.Presentation/Tasks/Edit/EditTasksForSimulation.cs
+++ b/src/MoBi.Presentation/Tasks/Edit/EditTasksForSimulation.cs
@@ -27,7 +27,9 @@ public interface IEditTasksForSimulation : IEditTaskFor<IMoBiSimulation>
       void ExportResultsToExcel(IMoBiSimulation simulation);
       void ExportResultsToExcel(IMoBiSimulation simulation, DataRepository dataRepository);
       void RenameResults(IMoBiSimulation simulation, DataRepository dataRepository);
-      void ExportMatlabDifferentialSystem(IMoBiSimulation simulation);
+      void ExportODEForMatlab(IMoBiSimulation simulation);
+      void ExportODEForR(IMoBiSimulation simulation);
+      void ExportSimulationToCppCode(IMoBiSimulation simulation);
       void ExportSimModelXml(IMoBiSimulation simulation);
       void CalculateScaleFactors(IMoBiSimulation simulation);
    }
@@ -37,7 +39,7 @@ public class EditTasksForSimulation : EditTasksForBuildingBlock<IMoBiSimulation>
       private readonly ISimulationPersistor _simulationPersistor;
       private readonly IDialogCreator _dialogCreator;
       private readonly IModelReportCreator _reportCreator;
-      private readonly IDataRepositoryTask _dataRepositoryTask;
+      private readonly IDataRepositoryExportTask _dataRepositoryTask;
       private readonly ISimModelExporter _simModelExporter;
       private readonly IDimensionFactory _dimensionFactory;
       private readonly IParameterIdentificationSimulationPathUpdater _parameterIdentificationSimulationPathUpdater;
@@ -46,7 +48,7 @@ public EditTasksForSimulation(
          IInteractionTaskContext interactionTaskContext,
          ISimulationPersistor simulationPersistor,
          IDialogCreator dialogCreator,
-         IDataRepositoryTask dataRepositoryTask,
+         IDataRepositoryExportTask dataRepositoryTask,
          IModelReportCreator reportCreator,
          ISimModelExporter simModelExporter,
          IDimensionFactory dimensionFactory,
@@ -123,11 +125,25 @@ public void RenameResults(IMoBiSimulation simulation, DataRepository dataReposit
          addCommand(new RenameSimulationResultsCommand(dataRepository, simulation, newName).Run(_context));
       }
 
-      public void ExportMatlabDifferentialSystem(IMoBiSimulation simulation)
+      public void ExportODEForMatlab(IMoBiSimulation simulation)
       {
-         var exportFolder = _interactionTask.AskForFolder(AppConstants.Dialog.ExportSimulationMatlabODE, Constants.DirectoryKey.SIM_MODEL_XML);
+         var exportFolder = _interactionTask.AskForFolder(AppConstants.Dialog.ExportODEForMatlab, Constants.DirectoryKey.SIM_MODEL_XML);
          if (string.IsNullOrEmpty(exportFolder)) return;
-         _simModelExporter.ExportODEForMatlab(simulation, exportFolder, MatlabFormulaExportMode.Formula);
+         _simModelExporter.ExportODEForMatlab(simulation, exportFolder, FormulaExportMode.Formula);
+      }
+
+      public void ExportODEForR(IMoBiSimulation simulation)
+      {
+         var exportFolder = _interactionTask.AskForFolder(AppConstants.Dialog.ExportODEForR, Constants.DirectoryKey.SIM_MODEL_XML);
+         if (string.IsNullOrEmpty(exportFolder)) return;
+         _simModelExporter.ExportODEForR(simulation, exportFolder, FormulaExportMode.Formula);
+      }
+
+      public void ExportSimulationToCppCode(IMoBiSimulation simulation)
+      {
+         var exportFolder = _interactionTask.AskForFolder(AppConstants.Dialog.ExportSimulationToCppCode, Constants.DirectoryKey.SIM_MODEL_XML);
+         if (string.IsNullOrEmpty(exportFolder)) return;
+         _simModelExporter.ExportCppCode(simulation, exportFolder, FormulaExportMode.Formula);
       }
 
       public void CalculateScaleFactors(IMoBiSimulation simulation)
@@ -168,7 +184,7 @@ public void ExportSimModelXml(IMoBiSimulation simulation)
       {
          var fileName = _dialogCreator.AskForFileToSave(AppConstants.Captions.Save, AppConstants.Filter.SIM_MODEL_FILE_FILTER, Constants.DirectoryKey.SIM_MODEL_XML, simulation.Name);
          if (fileName.IsNullOrEmpty()) return;
-         _simModelExporter.Export(simulation, fileName);
+         _simModelExporter.ExportSimModelXml(simulation, fileName);
       }
 
       public override void Rename(IMoBiSimulation simulationToRename, IEnumerable<IObjectBase> existingObjectsInParent, IBuildingBlock buildingBlock)
diff --git a/src/MoBi.Presentation/Tasks/FullPathDisplayResolver.cs b/src/MoBi.Presentation/Tasks/FullPathDisplayResolver.cs
deleted file mode 100644
index 952222008..000000000
--- a/src/MoBi.Presentation/Tasks/FullPathDisplayResolver.cs
+++ /dev/null
@@ -1,30 +0,0 @@
-using OSPSuite.Core.Domain;
-using OSPSuite.Core.Domain.Mappers;
-using OSPSuite.Core.Domain.Services;
-using OSPSuite.Presentation.Mappers;
-
-namespace MoBi.Presentation.Tasks
-{
-   public class FullPathDisplayResolver : IFullPathDisplayResolver
-   {
-      private readonly IQuantityPathToQuantityDisplayPathMapper _quantityDisplayPathMapper;
-
-      public FullPathDisplayResolver(IQuantityPathToQuantityDisplayPathMapper quantityDisplayPathMapper)
-      {
-         _quantityDisplayPathMapper = quantityDisplayPathMapper;
-      }
-
-      public string FullPathFor(IObjectBase objectBase, bool addSimulationName = false)
-      {
-         var quantity = objectBase as IQuantity;
-         if (quantity != null)
-            return _quantityDisplayPathMapper.DisplayPathAsStringFor(quantity, addSimulationName);
-
-         var entity = objectBase as IEntity;
-         if (entity != null)
-            return entity.EntityPath();
-
-         return objectBase.Name;
-      }
-   }
-}
\ No newline at end of file
diff --git a/src/MoBi.Presentation/Tasks/ISimModelManagerFactory.cs b/src/MoBi.Presentation/Tasks/ISimModelManagerFactory.cs
deleted file mode 100644
index fb0d20232..000000000
--- a/src/MoBi.Presentation/Tasks/ISimModelManagerFactory.cs
+++ /dev/null
@@ -1,9 +0,0 @@
-using OSPSuite.Core.Domain.Services;
-
-namespace MoBi.Presentation.Tasks
-{
-   public interface ISimModelManagerFactory
-   {
-      ISimModelManager Create();
-   }
-}
\ No newline at end of file
diff --git a/src/MoBi.Presentation/Tasks/Interaction/InteractionTasksForMoleculeBuildingBlock.cs b/src/MoBi.Presentation/Tasks/Interaction/InteractionTasksForMoleculeBuildingBlock.cs
index da0004861..d65e0c446 100644
--- a/src/MoBi.Presentation/Tasks/Interaction/InteractionTasksForMoleculeBuildingBlock.cs
+++ b/src/MoBi.Presentation/Tasks/Interaction/InteractionTasksForMoleculeBuildingBlock.cs
@@ -2,10 +2,8 @@
 using MoBi.Assets;
 using OSPSuite.Core.Commands.Core;
 using OSPSuite.Utility.Extensions;
-using MoBi.Core;
 using MoBi.Core.Commands;
 using MoBi.Core.Domain.Model;
-using MoBi.Core.Domain.Services;
 using MoBi.Core.Events;
 using MoBi.Core.Exceptions;
 using MoBi.Core.Helper;
@@ -14,7 +12,6 @@
 using OSPSuite.Core.Domain;
 using OSPSuite.Core.Domain.Builder;
 using OSPSuite.Core.Domain.Services;
-using OSPSuite.Infrastructure.Services;
 
 namespace MoBi.Presentation.Tasks.Interaction
 {
diff --git a/src/MoBi.Presentation/Tasks/ObservedDataTask.cs b/src/MoBi.Presentation/Tasks/ObservedDataTask.cs
index 3c0235acb..88ac1324d 100644
--- a/src/MoBi.Presentation/Tasks/ObservedDataTask.cs
+++ b/src/MoBi.Presentation/Tasks/ObservedDataTask.cs
@@ -49,8 +49,15 @@ public class ObservedDataTask : OSPSuite.Core.Domain.Services.ObservedDataTask,
       private readonly IDimension _molWeightDimension;
       private readonly IDialogCreator _mobiDialogCreator;
 
-      public ObservedDataTask(IDataImporter dataImporter, IDimensionFactory dimensionFactory, IMoBiContext context,
-         IDialogCreator dialogCreator, IInteractionTask interactionTask, IDataRepositoryTask dataRepositoryTask, IContainerTask containerTask, IObjectTypeResolver objectTypeResolver) : base(dialogCreator, context, dataRepositoryTask, containerTask, objectTypeResolver)
+      public ObservedDataTask(
+         IDataImporter dataImporter, 
+         IDimensionFactory dimensionFactory, 
+         IMoBiContext context,
+         IDialogCreator dialogCreator, 
+         IInteractionTask interactionTask, 
+         IDataRepositoryExportTask dataRepositoryTask, 
+         IContainerTask containerTask, 
+         IObjectTypeResolver objectTypeResolver) : base(dialogCreator, context, dataRepositoryTask, containerTask, objectTypeResolver)
       {
          _dataImporter = dataImporter;
          _mobiDialogCreator = dialogCreator;
@@ -127,7 +134,7 @@ public void DeleteAllResultsFromAllSimulation()
 
       private static MoBiMacroCommand deleteAllResultsFromSimulationCommand(IMoBiSimulation simulation)
       {
-         var macoCommand = new MoBiMacroCommand
+         var macroCommand = new MoBiMacroCommand
          {
             CommandType = Command.CommandTypeDelete,
             ObjectType = ObjectTypes.ObservedData,
@@ -135,17 +142,17 @@ private static MoBiMacroCommand deleteAllResultsFromSimulationCommand(IMoBiSimul
          };
 
          if (simulation.Results != null)
-            macoCommand.AddCommand(new ClearResultsCommand(simulation));
+            macroCommand.AddCommand(new ClearResultsCommand(simulation));
 
-         simulation.HistoricResults.Each(x => macoCommand.Add(new RemoveHistoricResultFromSimulationCommand(simulation, x)));
-         return macoCommand;
+         simulation.HistoricResults.Each(x => macroCommand.Add(new RemoveHistoricResultFromSimulationCommand(simulation, x)));
+         return macroCommand;
       }
 
       private DataImporterSettings createDataImportSettings()
       {
          var settings = new DataImporterSettings
          {
-            Icon = ApplicationIcons.MoBi,
+            IconName = ApplicationIcons.MoBi.IconName,
             Caption = $"{AppConstants.PRODUCT_NAME} - {AppConstants.Captions.ImportObservedData}"
          };
          settings.AddNamingPatternMetaData(Constants.FILE);
@@ -288,7 +295,7 @@ private void addDimensionsTo(ColumnInfo columnInfo, IDimension mainDimension)
       {
          var timeDimension = _dimensionFactory.Dimension(CoreConstants.Dimension.TIME);
 
-         foreach (var dimension in _dimensionFactory.Dimensions.Where(x => x != timeDimension))
+         foreach (var dimension in _dimensionFactory.DimensionsSortedByName.Where(x => x != timeDimension))
          {
             columnInfo.DimensionInfos.Add(new DimensionInfo
             {
@@ -390,7 +397,7 @@ private void addInfoToCategory(MetaDataCategory metaDataCategory, IContainer con
 
          var icon = ApplicationIcons.IconByName(container.Icon);
          if (icon != ApplicationIcons.EmptyIcon)
-            metaDataCategory.ListOfImages.Add(container.Name, icon);
+            metaDataCategory.ListOfImages.Add(container.Name, icon.IconName);
       }
 
       private MetaDataCategory createMetaDataCategory<T>(string categoryName, bool isMandatory = false, bool isListOfValuesFixed = false, Action<MetaDataCategory> fixedValuesRetriever = null, string description = null)
diff --git a/src/MoBi.Presentation/Tasks/OutputSelectionsRetriever.cs b/src/MoBi.Presentation/Tasks/OutputSelectionsRetriever.cs
index 3fc43f476..d2d1db0c0 100644
--- a/src/MoBi.Presentation/Tasks/OutputSelectionsRetriever.cs
+++ b/src/MoBi.Presentation/Tasks/OutputSelectionsRetriever.cs
@@ -33,7 +33,7 @@ public QuantitySelection SelectionFrom(IQuantity quantity)
 
       public void UpdatePersistableOutputsIn(IMoBiSimulation simulation)
       {
-         if (simulation.Settings == null)
+         if (simulation.SimulationSettings == null)
             return;
 
          var allPersistableParameters = simulation.Model.Root.GetAllChildren<IParameter>(x => x.Persistable);
diff --git a/src/MoBi.Presentation/Tasks/ProjectTask.cs b/src/MoBi.Presentation/Tasks/ProjectTask.cs
index 5ad575a33..10432bfd2 100644
--- a/src/MoBi.Presentation/Tasks/ProjectTask.cs
+++ b/src/MoBi.Presentation/Tasks/ProjectTask.cs
@@ -1,21 +1,18 @@
 using System;
-using System.Collections.Generic;
 using MoBi.Assets;
-using OSPSuite.Core.Commands.Core;
-using OSPSuite.Core.Services;
-using OSPSuite.Utility.Extensions;
-using MoBi.Core;
 using MoBi.Core.Domain.Builder;
 using MoBi.Core.Domain.Model;
 using MoBi.Core.Exceptions;
 using MoBi.Core.Services;
+using OSPSuite.Core.Commands.Core;
 using OSPSuite.Core.Domain;
 using OSPSuite.Core.Domain.Builder;
-using OSPSuite.Core.Domain.Data;
 using OSPSuite.Core.Domain.Services;
 using OSPSuite.Core.Events;
 using OSPSuite.Core.Serialization.Exchange;
+using OSPSuite.Core.Services;
 using OSPSuite.Presentation.Services;
+using OSPSuite.Utility.Extensions;
 
 namespace MoBi.Presentation.Tasks
 {
@@ -134,15 +131,6 @@ public SimulationTransfer LoadSimulationTransferDataFromFile(string fileName)
          {
             return loadSimulationTransferFromFileUsingDimensionMode(fileName, ReactionDimensionMode.ConcentrationBased);
          }
-         catch (NotMatchingSerializationFileException)
-         {
-            return new SimulationTransfer
-            {
-               Simulation = _serializationTask.Load<MoBiSimulation>(fileName),
-               AllObservedData = new List<DataRepository>(),
-               PkmlVersion = ProjectVersions.V3_0_4
-            };
-         }
       }
 
       private SimulationTransfer loadSimulationTransferFromFileUsingDimensionMode(string fileName, ReactionDimensionMode dimensionMode)
@@ -202,7 +190,7 @@ public bool Save()
 
       public bool SaveAs()
       {
-         bool defaultNameIsUndefined = string.Equals(Constants.ProjectUndefined, _context.CurrentProject.Name);
+         bool defaultNameIsUndefined = string.Equals(Constants.PROJECT_UNDEFINED, _context.CurrentProject.Name);
          var defaultFileName = defaultNameIsUndefined ? string.Empty : _context.CurrentProject.Name;
 
          var newFilePath = _dialogCreator.AskForFileToSave(AppConstants.Dialog.AskForSaveProject,
diff --git a/src/MoBi.Presentation/Tasks/SimulationRunner.cs b/src/MoBi.Presentation/Tasks/SimulationRunner.cs
index 66d6415e9..b1e945ab4 100644
--- a/src/MoBi.Presentation/Tasks/SimulationRunner.cs
+++ b/src/MoBi.Presentation/Tasks/SimulationRunner.cs
@@ -79,7 +79,7 @@ private bool settingsRequired(IMoBiSimulation simulation, bool defineSettings)
          if (defineSettings)
             return true;
 
-         if (simulation.Settings == null)
+         if (simulation.SimulationSettings == null)
             return true;
 
          return !simulation.OutputSelections.HasSelection;
@@ -101,17 +101,19 @@ private void startSimulationRun(IMoBiSimulation simulation)
          {
             addEvents();
             updatePersistableFor(simulation);
-            var results = _simModelManager.RunSimulation(_simulation);
+            var simulationRunResults = _simModelManager.RunSimulation(_simulation);
             _simulation.HasChanged = true;
-            showWarningsIfAny(results);
+            showWarningsIfAny(simulationRunResults);
 
-            if (results.Success)
+            if (simulationRunResults.Success)
             {
-               _displayUnitUpdater.UpdateDisplayUnitsIn(results.Results);
-               copyResultsToSimulation(results, _simulation);
+               var results = simulationRunResults.Results;
+               results.Name = getNewRepositoryName();
+               _displayUnitUpdater.UpdateDisplayUnitsIn(results);
+               copyResultsToSimulation(simulationRunResults, _simulation);
             }
 
-            addCommand(getSimulationResultLabel(results));
+            addCommand(getSimulationResultLabel(simulationRunResults));
          }
          finally
          {
@@ -121,6 +123,11 @@ private void startSimulationRun(IMoBiSimulation simulation)
          }
       }
 
+      private string getNewRepositoryName()
+      {
+         return AppConstants.ResultName + DateTime.Now.ToIsoFormat(withSeconds: true);
+      }
+
       private void addCommand(ICommand command)
       {
          _context.AddToHistory(command);
diff --git a/src/MoBi.Presentation/UICommand/ExportHistoryUICommand.cs b/src/MoBi.Presentation/UICommand/ExportHistoryUICommand.cs
index fde43fe5d..2897919dd 100644
--- a/src/MoBi.Presentation/UICommand/ExportHistoryUICommand.cs
+++ b/src/MoBi.Presentation/UICommand/ExportHistoryUICommand.cs
@@ -12,10 +12,10 @@ namespace MoBi.Presentation.UICommand
   public class ExportHistoryUICommand : IUICommand
    {
       private readonly IMoBiContext _context;
-      private readonly IReportTask _reportTask;
+      private readonly IHistoryExportTask _reportTask;
       private readonly IDialogCreator _dialogCreator;
 
-      public ExportHistoryUICommand(IMoBiContext context, IReportTask reportTask, IDialogCreator dialogCreator)
+      public ExportHistoryUICommand(IMoBiContext context, IHistoryExportTask reportTask, IDialogCreator dialogCreator)
       {
          _context = context;
          _reportTask = reportTask;
diff --git a/src/MoBi.Presentation/UICommand/ExportMatlabODEUICommand.cs b/src/MoBi.Presentation/UICommand/ExportMatlabODEUICommand.cs
deleted file mode 100644
index 0b8135ac5..000000000
--- a/src/MoBi.Presentation/UICommand/ExportMatlabODEUICommand.cs
+++ /dev/null
@@ -1,21 +0,0 @@
-using MoBi.Core.Domain.Model;
-using MoBi.Presentation.Tasks.Edit;
-using OSPSuite.Presentation.UICommands;
-
-namespace MoBi.Presentation.UICommand
-{
-   internal class ExportMatlabODEUICommand : ObjectUICommand<IMoBiSimulation>
-   {
-      private readonly IEditTasksForSimulation _editTasksesForSimulation;
-
-      public ExportMatlabODEUICommand(IEditTasksForSimulation editTasksForSimulation)
-      {
-         _editTasksesForSimulation = editTasksForSimulation;
-      }
-
-      protected override void PerformExecute()
-      {
-         _editTasksesForSimulation.ExportMatlabDifferentialSystem(Subject);
-      }
-   }
-}
\ No newline at end of file
diff --git a/src/MoBi.Presentation/UICommand/ExportODEForMatlabUICommand.cs b/src/MoBi.Presentation/UICommand/ExportODEForMatlabUICommand.cs
new file mode 100644
index 000000000..d8009125f
--- /dev/null
+++ b/src/MoBi.Presentation/UICommand/ExportODEForMatlabUICommand.cs
@@ -0,0 +1,21 @@
+using MoBi.Core.Domain.Model;
+using MoBi.Presentation.Tasks.Edit;
+using OSPSuite.Presentation.UICommands;
+
+namespace MoBi.Presentation.UICommand
+{
+   internal class ExportODEForMatlabUICommand : ObjectUICommand<IMoBiSimulation>
+   {
+      private readonly IEditTasksForSimulation _editTasksForSimulation;
+
+      public ExportODEForMatlabUICommand(IEditTasksForSimulation editTasksForSimulation)
+      {
+         _editTasksForSimulation = editTasksForSimulation;
+      }
+
+      protected override void PerformExecute()
+      {
+         _editTasksForSimulation.ExportODEForMatlab(Subject);
+      }
+   }
+}
\ No newline at end of file
diff --git a/src/MoBi.Presentation/UICommand/ExportODEForRUICommand.cs b/src/MoBi.Presentation/UICommand/ExportODEForRUICommand.cs
new file mode 100644
index 000000000..00ba9ccd0
--- /dev/null
+++ b/src/MoBi.Presentation/UICommand/ExportODEForRUICommand.cs
@@ -0,0 +1,21 @@
+using MoBi.Core.Domain.Model;
+using MoBi.Presentation.Tasks.Edit;
+using OSPSuite.Presentation.UICommands;
+
+namespace MoBi.Presentation.UICommand
+{
+  internal class ExportODEForRUICommand : ObjectUICommand<IMoBiSimulation>
+   {
+      private readonly IEditTasksForSimulation _editTasksForSimulation;
+
+      public ExportODEForRUICommand(IEditTasksForSimulation editTasksForSimulation)
+      {
+         _editTasksForSimulation = editTasksForSimulation;
+      }
+
+      protected override void PerformExecute()
+      {
+         _editTasksForSimulation.ExportODEForR(Subject);
+      }
+   }
+}
\ No newline at end of file
diff --git a/src/MoBi.Presentation/UICommand/ExportSimulationToCppUICommand.cs b/src/MoBi.Presentation/UICommand/ExportSimulationToCppUICommand.cs
new file mode 100644
index 000000000..4df1adc77
--- /dev/null
+++ b/src/MoBi.Presentation/UICommand/ExportSimulationToCppUICommand.cs
@@ -0,0 +1,21 @@
+using MoBi.Core.Domain.Model;
+using MoBi.Presentation.Tasks.Edit;
+using OSPSuite.Presentation.UICommands;
+
+namespace MoBi.Presentation.UICommand
+{
+   public class ExportSimulationToCppUICommand : ObjectUICommand<IMoBiSimulation>
+   {
+      private readonly IEditTasksForSimulation _editTasksForSimulation;
+
+      public ExportSimulationToCppUICommand(IEditTasksForSimulation editTasksForSimulation)
+      {
+         _editTasksForSimulation = editTasksForSimulation;
+      }
+
+      protected override void PerformExecute()
+      {
+         _editTasksForSimulation.ExportSimulationToCppCode(Subject);
+      }
+   }
+}
\ No newline at end of file
diff --git a/src/MoBi.Presentation/UICommand/ExportSimulationToSimModelXml.cs b/src/MoBi.Presentation/UICommand/ExportSimulationToSimModelXml.cs
deleted file mode 100644
index 0a62d01a5..000000000
--- a/src/MoBi.Presentation/UICommand/ExportSimulationToSimModelXml.cs
+++ /dev/null
@@ -1,22 +0,0 @@
-using MoBi.Core.Domain.Model;
-using MoBi.Presentation.Tasks.Edit;
-using OSPSuite.Presentation.UICommands;
-
-namespace MoBi.Presentation.UICommand
-{
-   public class ExportSimulationToSimModelXml : ObjectUICommand<IMoBiSimulation>
-   {
-      private readonly IEditTasksForSimulation _editTasksesForSimulation;
-
-      public ExportSimulationToSimModelXml(IEditTasksForSimulation editTasksForSimulation)
-      {
-         _editTasksesForSimulation = editTasksForSimulation;
-      }
-
-      protected override void PerformExecute()
-      {
-         _editTasksesForSimulation.ExportSimModelXml(Subject);
-      }
-
-   }
-}
\ No newline at end of file
diff --git a/src/MoBi.Presentation/UICommand/ExportSimulationToSimModelXmlUICommand.cs b/src/MoBi.Presentation/UICommand/ExportSimulationToSimModelXmlUICommand.cs
new file mode 100644
index 000000000..4a385c5bf
--- /dev/null
+++ b/src/MoBi.Presentation/UICommand/ExportSimulationToSimModelXmlUICommand.cs
@@ -0,0 +1,21 @@
+using MoBi.Core.Domain.Model;
+using MoBi.Presentation.Tasks.Edit;
+using OSPSuite.Presentation.UICommands;
+
+namespace MoBi.Presentation.UICommand
+{
+   public class ExportSimulationToSimModelXmlUICommand : ObjectUICommand<IMoBiSimulation>
+   {
+      private readonly IEditTasksForSimulation _editTasksForSimulation;
+
+      public ExportSimulationToSimModelXmlUICommand(IEditTasksForSimulation editTasksForSimulation)
+      {
+         _editTasksForSimulation = editTasksForSimulation;
+      }
+
+      protected override void PerformExecute()
+      {
+         _editTasksForSimulation.ExportSimModelXml(Subject);
+      }
+   }
+}
\ No newline at end of file
diff --git a/src/MoBi.Presentation/Views/BaseDiagram/IMoBiBaseDiagramView.cs b/src/MoBi.Presentation/Views/BaseDiagram/IMoBiBaseDiagramView.cs
index 9220735ea..a84d61862 100644
--- a/src/MoBi.Presentation/Views/BaseDiagram/IMoBiBaseDiagramView.cs
+++ b/src/MoBi.Presentation/Views/BaseDiagram/IMoBiBaseDiagramView.cs
@@ -1,3 +1,4 @@
+using System.Windows.Forms;
 using MoBi.Presentation.Presenter.BaseDiagram;
 using OSPSuite.Core.Diagram;
 using OSPSuite.Presentation.Views;
@@ -9,5 +10,6 @@ public interface IMoBiBaseDiagramView : IView<IMoBiBaseDiagramPresenter>, IBaseD
    {
       void ExpandParents(IBaseNode baseNode);
       bool IsMoleculeNode(IBaseNode baseNode);
+      Control Overview { set; }
    }
 }
\ No newline at end of file
diff --git a/src/MoBi.Presentation/Views/IEditParameterListView.cs b/src/MoBi.Presentation/Views/IEditParameterListView.cs
index bc3d62403..27aa9349f 100644
--- a/src/MoBi.Presentation/Views/IEditParameterListView.cs
+++ b/src/MoBi.Presentation/Views/IEditParameterListView.cs
@@ -10,8 +10,8 @@ public interface IEditParameterListView : IView<IEditParameterListPresenter>
    {
       void BindTo(IEnumerable<ParameterDTO> parameters);
       void Select(ParameterDTO parameterDTO);
-      void SetCaptions(IDictionary<PathElement, string> captions);
-      void SetVisibility(PathElement pathElement, bool isVisible);
+      void SetCaptions(IDictionary<PathElementId, string> captions);
+      void SetVisibility(PathElementId pathElement, bool isVisible);
       IReadOnlyList<ParameterDTO> SelectedParameters { get; set; }
    }
 }
\ No newline at end of file
diff --git a/src/MoBi.Presentation/Views/ISolverMessageView.cs b/src/MoBi.Presentation/Views/ISolverMessageView.cs
index d671d1c8d..fc89e7c07 100644
--- a/src/MoBi.Presentation/Views/ISolverMessageView.cs
+++ b/src/MoBi.Presentation/Views/ISolverMessageView.cs
@@ -2,6 +2,7 @@
 using MoBi.Presentation.Presenter;
 using OSPSuite.Core.Domain;
 using OSPSuite.Presentation.Views;
+using OSPSuite.SimModel;
 
 namespace MoBi.Presentation.Views
 {
diff --git a/src/MoBi.Presentation/app.config b/src/MoBi.Presentation/app.config
deleted file mode 100644
index 64b712bb6..000000000
--- a/src/MoBi.Presentation/app.config
+++ /dev/null
@@ -1,115 +0,0 @@
-<?xml version="1.0" encoding="utf-8"?>
-<configuration>
-  <runtime>
-    <assemblyBinding xmlns="urn:schemas-microsoft-com:asm.v1">
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.Utils.v18.2" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.Data.v18.2" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.XtraTreeList.v18.2" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.XtraEditors.v18.2" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.XtraBars.v18.2" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.XtraGrid.v18.2" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.XtraCharts.v18.2.UI" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.XtraCharts.v18.2" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.XtraPivotGrid.v18.2" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.PivotGrid.v18.2.Core" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.RichEdit.v18.2.Core" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.XtraRichEdit.v18.2" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.XtraRichEdit.v18.2.Extensions" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.Charts.v18.2.Core" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.Office.v18.2.Core" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.BonusSkins.v18.2" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.XtraLayout.v18.2" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="MPFitLib" publicKeyToken="be1b3c0b5819660a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-1.1.0.0" newVersion="1.1.0.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="SX" publicKeyToken="882b9c044052e7f6" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-2.7.0.9" newVersion="2.7.0.9" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="ICSharpCode.SharpZipLib" publicKeyToken="1b03e6acf1164f73" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-0.86.0.518" newVersion="0.86.0.518" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="System.Data.SQLite" publicKeyToken="db937bc2d44ff139" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-1.0.110.0" newVersion="1.0.110.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="Northwoods.Go" publicKeyToken="a4e3b7b70161cfe8" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-4.1.0.2" newVersion="4.1.0.2" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="Northwoods.Go.Xml" publicKeyToken="a4e3b7b70161cfe8" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-5.2.0.45" newVersion="5.2.0.45" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="Northwoods.Go.Layout" publicKeyToken="a4e3b7b70161cfe8" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-5.2.0.45" newVersion="5.2.0.45" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="NHibernate" publicKeyToken="aa95f207798dfdb4" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-5.2.0.0" newVersion="5.2.0.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="Iesi.Collections" publicKeyToken="aa95f207798dfdb4" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-4.0.0.4000" newVersion="4.0.0.4000" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="Newtonsoft.Json" publicKeyToken="30ad4fe6b2a6aeed" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-10.0.0.0" newVersion="10.0.0.0" />
-      </dependentAssembly>
-    </assemblyBinding>
-  </runtime>
-<startup><supportedRuntime version="v4.0" sku=".NETFramework,Version=v4.6.2" /></startup></configuration>
diff --git a/src/MoBi.Presentation/packages.config b/src/MoBi.Presentation/packages.config
deleted file mode 100644
index feb7f1bca..000000000
--- a/src/MoBi.Presentation/packages.config
+++ /dev/null
@@ -1,43 +0,0 @@
-<?xml version="1.0" encoding="utf-8"?>
-<packages>
-  <package id="Antlr3.Runtime" version="3.5.1" targetFramework="net462" />
-  <package id="Castle.Core" version="4.3.1" targetFramework="net462" />
-  <package id="Castle.Windsor" version="4.1.1" targetFramework="net462" />
-  <package id="csmpfit" version="1.1.1" targetFramework="net462" />
-  <package id="Dapper" version="1.60.6" targetFramework="net462" />
-  <package id="FakeItEasy" version="5.1.1" targetFramework="net462" />
-  <package id="FluentNHibernate" version="2.1.2" targetFramework="net462" />
-  <package id="Iesi.Collections" version="4.0.4" targetFramework="net462" />
-  <package id="MathNet.Numerics" version="4.7.0" targetFramework="net462" />
-  <package id="Microsoft.Extensions.Configuration" version="2.2.0" targetFramework="net462" />
-  <package id="Microsoft.Extensions.Configuration.Abstractions" version="2.2.0" targetFramework="net462" />
-  <package id="Microsoft.Extensions.Configuration.Binder" version="2.2.0" targetFramework="net462" />
-  <package id="Microsoft.Extensions.DependencyInjection.Abstractions" version="2.2.0" targetFramework="net462" />
-  <package id="Microsoft.Extensions.Logging" version="2.2.0" targetFramework="net462" />
-  <package id="Microsoft.Extensions.Logging.Abstractions" version="2.2.0" targetFramework="net462" />
-  <package id="Microsoft.Extensions.Options" version="2.2.0" targetFramework="net462" />
-  <package id="Microsoft.Extensions.Primitives" version="2.2.0" targetFramework="net462" />
-  <package id="Newtonsoft.Json" version="12.0.1" targetFramework="net462" />
-  <package id="NHibernate" version="5.2.5" targetFramework="net462" />
-  <package id="Northwoods.GoWin" version="5.2.0" targetFramework="net462" />
-  <package id="OSPSuite.Assets" version="8.0.4" targetFramework="net462" />
-  <package id="OSPSuite.Core" version="8.0.4" targetFramework="net462" />
-  <package id="OSPSuite.DevExpress" version="18.2.7" targetFramework="net462" />
-  <package id="OSPSuite.DevExpress.Presentation" version="18.2.7" targetFramework="net462" />
-  <package id="OSPSuite.Infrastructure" version="8.0.4" targetFramework="net462" />
-  <package id="OSPSuite.Presentation" version="8.0.4" targetFramework="net462" />
-  <package id="OSPSuite.Serializer" version="2.0.1.4" targetFramework="net462" />
-  <package id="OSPSuite.SmartXLS" version="2.7.0.9" targetFramework="net462" />
-  <package id="OSPSuite.TeXReporting" version="2.1.1.9" targetFramework="net462" />
-  <package id="OSPSuite.Utility" version="3.0.1.7" targetFramework="net462" />
-  <package id="Remotion.Linq" version="2.2.0" targetFramework="net462" />
-  <package id="Remotion.Linq.EagerFetching" version="2.2.0" targetFramework="net462" />
-  <package id="SharpZipLib" version="1.1.0" targetFramework="net462" />
-  <package id="System.Buffers" version="4.4.0" targetFramework="net462" />
-  <package id="System.ComponentModel.Annotations" version="4.5.0" targetFramework="net462" />
-  <package id="System.Data.SQLite.Core" version="1.0.110.0" targetFramework="net462" />
-  <package id="System.Memory" version="4.5.1" targetFramework="net462" />
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diff --git a/src/MoBi.UI/MoBi.UI.csproj b/src/MoBi.UI/MoBi.UI.csproj
index 113f33575..f9fec814f 100644
--- a/src/MoBi.UI/MoBi.UI.csproj
+++ b/src/MoBi.UI/MoBi.UI.csproj
@@ -1,1527 +1,56 @@
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-    <WarningLevel>4</WarningLevel>
-    <PlatformTarget>AnyCPU</PlatformTarget>
-    <DocumentationFile>bin\Debug\MoBi.UI.xml</DocumentationFile>
+    <TargetFramework>net472</TargetFramework>
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+    <PackageVersion>9.0.0</PackageVersion>
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+    <FileVersion>9.0.0</FileVersion>
+    <InformationalVersion>9.0.0</InformationalVersion>
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+    <GenerateAssemblyCompanyAttribute>false</GenerateAssemblyCompanyAttribute>
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-      <SubType>Designer</SubType>
-    </EmbeddedResource>
-    <EmbeddedResource Include="Views\EditDimensionView.resx">
-      <DependentUpon>EditDimensionView.cs</DependentUpon>
-      <SubType>Designer</SubType>
-    </EmbeddedResource>
-    <EmbeddedResource Include="Views\EditReactionBuilderView.resx">
-      <DependentUpon>EditReactionBuilderView.cs</DependentUpon>
-      <SubType>Designer</SubType>
-    </EmbeddedResource>
-    <EmbeddedResource Include="Views\EditReactionBuildingBlockView.resx">
-      <DependentUpon>EditReactionBuildingBlockView.cs</DependentUpon>
-      <SubType>Designer</SubType>
-    </EmbeddedResource>
-    <EmbeddedResource Include="Views\EditMoleculesBuildingBlockView.resx">
-      <DependentUpon>EditMoleculesBuildingBlockView.cs</DependentUpon>
-      <SubType>Designer</SubType>
-    </EmbeddedResource>
-    <EmbeddedResource Include="Views\ReactionListView.resx">
-      <DependentUpon>ReactionListView.cs</DependentUpon>
-      <SubType>Designer</SubType>
-    </EmbeddedResource>
-    <EmbeddedResource Include="Views\FinalOptionsView.resx">
-      <DependentUpon>FinalOptionsView.cs</DependentUpon>
-      <SubType>Designer</SubType>
-    </EmbeddedResource>
-    <EmbeddedResource Include="Views\BuildingBlockSelectionView.resx">
-      <DependentUpon>BuildingBlockSelectionView.cs</DependentUpon>
-      <SubType>Designer</SubType>
-    </EmbeddedResource>
-    <EmbeddedResource Include="Views\MoBiMainView.resx">
-      <DependentUpon>MoBiMainView.cs</DependentUpon>
-      <SubType>Designer</SubType>
-    </EmbeddedResource>
-    <EmbeddedResource Include="Properties\Resources.resx">
-      <Generator>ResXFileCodeGenerator</Generator>
-      <LastGenOutput>Resources.Designer.cs</LastGenOutput>
-      <SubType>Designer</SubType>
-    </EmbeddedResource>
-    <EmbeddedResource Include="Views\OutputSelectionsView.resx">
-      <DependentUpon>OutputSelectionsView.cs</DependentUpon>
-    </EmbeddedResource>
-    <EmbeddedResource Include="Views\SimulationView\EditSimulationView.resx">
-      <DependentUpon>EditSimulationView.cs</DependentUpon>
-      <SubType>Designer</SubType>
-    </EmbeddedResource>
-    <EmbeddedResource Include="Views\SolverMessageView.resx">
-      <DependentUpon>SolverMessageView.cs</DependentUpon>
-      <SubType>Designer</SubType>
-    </EmbeddedResource>
-    <EmbeddedResource Include="Views\SplashScreen.resx">
-      <DependentUpon>SplashScreen.cs</DependentUpon>
-      <SubType>Designer</SubType>
-    </EmbeddedResource>
-    <EmbeddedResource Include="Views\StringSelectionListBox.resx">
-      <DependentUpon>StringSelectionListBox.cs</DependentUpon>
-      <SubType>Designer</SubType>
-    </EmbeddedResource>
-    <EmbeddedResource Include="Views\UserSettingsView.resx">
-      <DependentUpon>UserSettingsView.cs</DependentUpon>
-      <SubType>Designer</SubType>
-    </EmbeddedResource>
-    <EmbeddedResource Include="Views\ValidationMessagesView.resx">
-      <DependentUpon>ValidationMessagesView.cs</DependentUpon>
-      <SubType>Designer</SubType>
-    </EmbeddedResource>
-    <EmbeddedResource Include="Views\ValidationOptionsView.resx">
-      <DependentUpon>ValidationOptionsView.cs</DependentUpon>
-    </EmbeddedResource>
-    <EmbeddedResource Include="Views\ValueEdit.resx">
-      <DependentUpon>ValueEdit.cs</DependentUpon>
-      <SubType>Designer</SubType>
-    </EmbeddedResource>
-    <Compile Include="Properties\Resources.Designer.cs">
-      <AutoGen>True</AutoGen>
-      <DependentUpon>Resources.resx</DependentUpon>
-      <DesignTime>True</DesignTime>
-    </Compile>
-    <None Include="app.config">
-      <SubType>Designer</SubType>
-    </None>
-    <None Include="MoBi.config" />
-    <None Include="packages.config" />
-    <None Include="Properties\Settings.settings">
-      <Generator>SettingsSingleFileGenerator</Generator>
-      <LastGenOutput>Settings.Designer.cs</LastGenOutput>
-    </None>
-    <Compile Include="Properties\Settings.Designer.cs">
-      <AutoGen>True</AutoGen>
-      <DependentUpon>Settings.settings</DependentUpon>
-      <DesignTimeSharedInput>True</DesignTimeSharedInput>
-    </Compile>
-    <Compile Include="Views\StringSelectionListBox.cs" />
-    <Compile Include="Views\StringSelectionListBox.Designer.cs">
-      <DependentUpon>StringSelectionListBox.cs</DependentUpon>
-    </Compile>
-    <Compile Include="Views\ValidationOptionsView.cs">
-      <SubType>UserControl</SubType>
-    </Compile>
-    <Compile Include="Views\ValidationOptionsView.Designer.cs">
-      <DependentUpon>ValidationOptionsView.cs</DependentUpon>
-    </Compile>
-    <Compile Include="Views\ValueEdit.cs">
-      <SubType>UserControl</SubType>
-    </Compile>
-    <Compile Include="Views\ValueEdit.Designer.cs">
-      <DependentUpon>ValueEdit.cs</DependentUpon>
-    </Compile>
-    <Compile Include="Views\ObserverListView.cs">
-      <SubType>UserControl</SubType>
-    </Compile>
-    <Compile Include="Views\ObserverListView.Designer.cs">
-      <DependentUpon>ObserverListView.cs</DependentUpon>
-    </Compile>
-    <Compile Include="Views\EditApplicationBuilderView.cs">
-      <SubType>UserControl</SubType>
-    </Compile>
-    <Compile Include="Views\EditApplicationBuilderView.Designer.cs">
-      <DependentUpon>EditApplicationBuilderView.cs</DependentUpon>
-    </Compile>
-    <Compile Include="Views\EditTableFormulaView.cs">
-      <SubType>UserControl</SubType>
-    </Compile>
-    <Compile Include="Views\EditTableFormulaView.Designer.cs">
-      <DependentUpon>EditTableFormulaView.cs</DependentUpon>
-    </Compile>
+    <PackageReference Include="Microsoft.Extensions.Logging" Version="2.2.0" />
+    <PackageReference Include="Microsoft.Extensions.Logging.Debug" Version="2.2.0" />
+    <PackageReference Include="OSPSuite.DataBinding" Version="3.0.0.4" />
+    <PackageReference Include="OSPSuite.DataBinding.DevExpress" Version="4.0.0.1" />
+    <PackageReference Include="OSPSuite.DevExpress" Version="19.2.4.1" />
+    <PackageReference Include="OSPSuite.Infrastructure" Version="9.0.137" />
+    <PackageReference Include="OSPSuite.Infrastructure.Castle" Version="9.0.137" />
+    <PackageReference Include="OSPSuite.Presentation" Version="9.0.137" />
+    <PackageReference Include="OSPSuite.UI" Version="9.0.137" />
+    <PackageReference Include="OSPSuite.UI.Importer" Version="9.0.137" />
+    <PackageReference Include="OSPSuite.Utility" Version="4.0.0.4" />
+    <PackageReference Include="OSPSuite.Core" Version="9.0.137" />
   </ItemGroup>
+
   <ItemGroup>
-    <Content Include="MoBi.ico">
-      <CopyToOutputDirectory>Always</CopyToOutputDirectory>
-    </Content>
-    <None Include="Resources\OK.ico" />
-    <None Include="Resources\Cancel.ico" />
-  </ItemGroup>
-  <ItemGroup>
-    <BootstrapperPackage Include="Microsoft.Net.Framework.2.0">
-      <Visible>False</Visible>
-      <ProductName>.NET Framework 2.0 %28x86%29</ProductName>
-      <Install>false</Install>
-    </BootstrapperPackage>
-    <BootstrapperPackage Include="Microsoft.Net.Framework.3.0">
-      <Visible>False</Visible>
-      <ProductName>.NET Framework 3.0 %28x86%29</ProductName>
-      <Install>false</Install>
-    </BootstrapperPackage>
-    <BootstrapperPackage Include="Microsoft.Net.Framework.3.5">
-      <Visible>False</Visible>
-      <ProductName>.NET Framework 3.5</ProductName>
-      <Install>true</Install>
-    </BootstrapperPackage>
-    <BootstrapperPackage Include="Microsoft.Windows.Installer.3.1">
-      <Visible>False</Visible>
-      <ProductName>Windows Installer 3.1</ProductName>
-      <Install>true</Install>
-    </BootstrapperPackage>
+    <None Include="..\..\LICENSE">
+      <Pack>True</Pack>
+      <PackagePath></PackagePath>
+    </None>
   </ItemGroup>
+
   <ItemGroup>
-    <ProjectReference Include="..\MoBi.Core\MoBi.Core.csproj">
-      <Project>{2DBF50BE-A749-421C-B526-8BDA31CFE7B3}</Project>
-      <Name>MoBi.Core</Name>
-    </ProjectReference>
-    <ProjectReference Include="..\MoBi.Presentation\MoBi.Presentation.csproj">
-      <Project>{B4C86DCA-8877-4400-8088-2401EE65B403}</Project>
-      <Name>MoBi.Presentation</Name>
-    </ProjectReference>
-    <ProjectReference Include="..\MoBi.Assets\MoBi.Assets.csproj">
-      <Project>{3C65FFC2-D9EC-4951-8C35-04854AD34E52}</Project>
-      <Name>MoBi.Assets</Name>
-    </ProjectReference>
+    <ProjectReference Include="..\MoBi.Assets\MoBi.Assets.csproj" />
+    <ProjectReference Include="..\MoBi.Core\MoBi.Core.csproj" />
+    <ProjectReference Include="..\MoBi.Presentation\MoBi.Presentation.csproj" />
   </ItemGroup>
+
   <ItemGroup>
-    <Folder Include="Mappers\" />
+    <Reference Include="Microsoft.VisualBasic" />
+    <Reference Include="System.Windows.Forms" />
   </ItemGroup>
-  <Import Project="$(MSBuildToolsPath)\Microsoft.CSharp.targets" />
-  <!-- To modify your build process, add your task inside one of the targets below and uncomment it. 
-       Other similar extension points exist, see Microsoft.Common.targets.
-  <Target Name="BeforeBuild">
-  </Target>
-  <Target Name="AfterBuild">
-  </Target>
-  -->
-  <PropertyGroup>
-    <PreBuildEvent>
-    </PreBuildEvent>
-    <PostBuildEvent>
-    </PostBuildEvent>
-  </PropertyGroup>
-  <Import Project="..\..\packages\System.Data.SQLite.Core.1.0.110.0\build\net46\System.Data.SQLite.Core.targets" Condition="Exists('..\..\packages\System.Data.SQLite.Core.1.0.110.0\build\net46\System.Data.SQLite.Core.targets')" />
-  <Target Name="EnsureNuGetPackageBuildImports" BeforeTargets="PrepareForBuild">
-    <PropertyGroup>
-      <ErrorText>This project references NuGet package(s) that are missing on this computer. Use NuGet Package Restore to download them.  For more information, see http://go.microsoft.com/fwlink/?LinkID=322105. The missing file is {0}.</ErrorText>
-    </PropertyGroup>
-    <Error Condition="!Exists('..\..\packages\System.Data.SQLite.Core.1.0.110.0\build\net46\System.Data.SQLite.Core.targets')" Text="$([System.String]::Format('$(ErrorText)', '..\..\packages\System.Data.SQLite.Core.1.0.110.0\build\net46\System.Data.SQLite.Core.targets'))" />
-  </Target>
-</Project>
\ No newline at end of file
+
+</Project>
diff --git a/src/MoBi.UI/Properties/AssemblyInfo.cs b/src/MoBi.UI/Properties/AssemblyInfo.cs
deleted file mode 100644
index cf2737718..000000000
--- a/src/MoBi.UI/Properties/AssemblyInfo.cs
+++ /dev/null
@@ -1,9 +0,0 @@
-using System.Reflection;
-
-// General Information about an assembly is controlled through the following 
-// set of attributes. Change these attribute values to modify the information
-// associated with an assembly.
-
-[assembly: AssemblyTitle("MoBi-Application")]
-[assembly: AssemblyDescription("")]
-[assembly: AssemblyCulture("")]
diff --git a/src/MoBi.UI/Properties/Resources.Designer.cs b/src/MoBi.UI/Properties/Resources.Designer.cs
deleted file mode 100644
index f434b03ab..000000000
--- a/src/MoBi.UI/Properties/Resources.Designer.cs
+++ /dev/null
@@ -1,83 +0,0 @@
-//------------------------------------------------------------------------------
-// <auto-generated>
-//     This code was generated by a tool.
-//     Runtime Version:4.0.30319.42000
-//
-//     Changes to this file may cause incorrect behavior and will be lost if
-//     the code is regenerated.
-// </auto-generated>
-//------------------------------------------------------------------------------
-
-namespace MoBi.UI.Properties {
-    using System;
-    
-    
-    /// <summary>
-    ///   A strongly-typed resource class, for looking up localized strings, etc.
-    /// </summary>
-    // This class was auto-generated by the StronglyTypedResourceBuilder
-    // class via a tool like ResGen or Visual Studio.
-    // To add or remove a member, edit your .ResX file then rerun ResGen
-    // with the /str option, or rebuild your VS project.
-    [global::System.CodeDom.Compiler.GeneratedCodeAttribute("System.Resources.Tools.StronglyTypedResourceBuilder", "15.0.0.0")]
-    [global::System.Diagnostics.DebuggerNonUserCodeAttribute()]
-    [global::System.Runtime.CompilerServices.CompilerGeneratedAttribute()]
-    internal class Resources {
-        
-        private static global::System.Resources.ResourceManager resourceMan;
-        
-        private static global::System.Globalization.CultureInfo resourceCulture;
-        
-        [global::System.Diagnostics.CodeAnalysis.SuppressMessageAttribute("Microsoft.Performance", "CA1811:AvoidUncalledPrivateCode")]
-        internal Resources() {
-        }
-        
-        /// <summary>
-        ///   Returns the cached ResourceManager instance used by this class.
-        /// </summary>
-        [global::System.ComponentModel.EditorBrowsableAttribute(global::System.ComponentModel.EditorBrowsableState.Advanced)]
-        internal static global::System.Resources.ResourceManager ResourceManager {
-            get {
-                if (object.ReferenceEquals(resourceMan, null)) {
-                    global::System.Resources.ResourceManager temp = new global::System.Resources.ResourceManager("MoBi.UI.Properties.Resources", typeof(Resources).Assembly);
-                    resourceMan = temp;
-                }
-                return resourceMan;
-            }
-        }
-        
-        /// <summary>
-        ///   Overrides the current thread's CurrentUICulture property for all
-        ///   resource lookups using this strongly typed resource class.
-        /// </summary>
-        [global::System.ComponentModel.EditorBrowsableAttribute(global::System.ComponentModel.EditorBrowsableState.Advanced)]
-        internal static global::System.Globalization.CultureInfo Culture {
-            get {
-                return resourceCulture;
-            }
-            set {
-                resourceCulture = value;
-            }
-        }
-        
-        /// <summary>
-        ///   Looks up a localized resource of type System.Drawing.Bitmap.
-        /// </summary>
-        internal static System.Drawing.Bitmap Cancel {
-            get {
-                object obj = ResourceManager.GetObject("Cancel", resourceCulture);
-                return ((System.Drawing.Bitmap)(obj));
-            }
-        }
-        
-        /// <summary>
-        ///   Looks up a localized resource of type System.Drawing.Bitmap.
-        /// </summary>
-        internal static System.Drawing.Bitmap OK {
-            get {
-                object obj = ResourceManager.GetObject("OK", resourceCulture);
-                return ((System.Drawing.Bitmap)(obj));
-            }
-        }
-    }
-}
diff --git a/src/MoBi.UI/Properties/Resources.resx b/src/MoBi.UI/Properties/Resources.resx
deleted file mode 100644
index 4390e0e49..000000000
--- a/src/MoBi.UI/Properties/Resources.resx
+++ /dev/null
@@ -1,127 +0,0 @@
-<?xml version="1.0" encoding="utf-8"?>
-<root>
-  <!-- 
-    Microsoft ResX Schema 
-    
-    Version 2.0
-    
-    The primary goals of this format is to allow a simple XML format 
-    that is mostly human readable. The generation and parsing of the 
-    various data types are done through the TypeConverter classes 
-    associated with the data types.
-    
-    Example:
-    
-    ... ado.net/XML headers & schema ...
-    <resheader name="resmimetype">text/microsoft-resx</resheader>
-    <resheader name="version">2.0</resheader>
-    <resheader name="reader">System.Resources.ResXResourceReader, System.Windows.Forms, ...</resheader>
-    <resheader name="writer">System.Resources.ResXResourceWriter, System.Windows.Forms, ...</resheader>
-    <data name="Name1"><value>this is my long string</value><comment>this is a comment</comment></data>
-    <data name="Color1" type="System.Drawing.Color, System.Drawing">Blue</data>
-    <data name="Bitmap1" mimetype="application/x-microsoft.net.object.binary.base64">
-        <value>[base64 mime encoded serialized .NET Framework object]</value>
-    </data>
-    <data name="Icon1" type="System.Drawing.Icon, System.Drawing" mimetype="application/x-microsoft.net.object.bytearray.base64">
-        <value>[base64 mime encoded string representing a byte array form of the .NET Framework object]</value>
-        <comment>This is a comment</comment>
-    </data>
-                
-    There are any number of "resheader" rows that contain simple 
-    name/value pairs.
-    
-    Each data row contains a name, and value. The row also contains a 
-    type or mimetype. Type corresponds to a .NET class that support 
-    text/value conversion through the TypeConverter architecture. 
-    Classes that don't support this are serialized and stored with the 
-    mimetype set.
-    
-    The mimetype is used for serialized objects, and tells the 
-    ResXResourceReader how to depersist the object. This is currently not 
-    extensible. For a given mimetype the value must be set accordingly:
-    
-    Note - application/x-microsoft.net.object.binary.base64 is the format 
-    that the ResXResourceWriter will generate, however the reader can 
-    read any of the formats listed below.
-    
-    mimetype: application/x-microsoft.net.object.binary.base64
-    value   : The object must be serialized with 
-            : System.Runtime.Serialization.Formatters.Binary.BinaryFormatter
-            : and then encoded with base64 encoding.
-    
-    mimetype: application/x-microsoft.net.object.soap.base64
-    value   : The object must be serialized with 
-            : System.Runtime.Serialization.Formatters.Soap.SoapFormatter
-            : and then encoded with base64 encoding.
-
-    mimetype: application/x-microsoft.net.object.bytearray.base64
-    value   : The object must be serialized into a byte array 
-            : using a System.ComponentModel.TypeConverter
-            : and then encoded with base64 encoding.
-    -->
-  <xsd:schema id="root" xmlns="" xmlns:xsd="http://www.w3.org/2001/XMLSchema" xmlns:msdata="urn:schemas-microsoft-com:xml-msdata">
-    <xsd:import namespace="http://www.w3.org/XML/1998/namespace" />
-    <xsd:element name="root" msdata:IsDataSet="true">
-      <xsd:complexType>
-        <xsd:choice maxOccurs="unbounded">
-          <xsd:element name="metadata">
-            <xsd:complexType>
-              <xsd:sequence>
-                <xsd:element name="value" type="xsd:string" minOccurs="0" />
-              </xsd:sequence>
-              <xsd:attribute name="name" use="required" type="xsd:string" />
-              <xsd:attribute name="type" type="xsd:string" />
-              <xsd:attribute name="mimetype" type="xsd:string" />
-              <xsd:attribute ref="xml:space" />
-            </xsd:complexType>
-          </xsd:element>
-          <xsd:element name="assembly">
-            <xsd:complexType>
-              <xsd:attribute name="alias" type="xsd:string" />
-              <xsd:attribute name="name" type="xsd:string" />
-            </xsd:complexType>
-          </xsd:element>
-          <xsd:element name="data">
-            <xsd:complexType>
-              <xsd:sequence>
-                <xsd:element name="value" type="xsd:string" minOccurs="0" msdata:Ordinal="1" />
-                <xsd:element name="comment" type="xsd:string" minOccurs="0" msdata:Ordinal="2" />
-              </xsd:sequence>
-              <xsd:attribute name="name" type="xsd:string" use="required" msdata:Ordinal="1" />
-              <xsd:attribute name="type" type="xsd:string" msdata:Ordinal="3" />
-              <xsd:attribute name="mimetype" type="xsd:string" msdata:Ordinal="4" />
-              <xsd:attribute ref="xml:space" />
-            </xsd:complexType>
-          </xsd:element>
-          <xsd:element name="resheader">
-            <xsd:complexType>
-              <xsd:sequence>
-                <xsd:element name="value" type="xsd:string" minOccurs="0" msdata:Ordinal="1" />
-              </xsd:sequence>
-              <xsd:attribute name="name" type="xsd:string" use="required" />
-            </xsd:complexType>
-          </xsd:element>
-        </xsd:choice>
-      </xsd:complexType>
-    </xsd:element>
-  </xsd:schema>
-  <resheader name="resmimetype">
-    <value>text/microsoft-resx</value>
-  </resheader>
-  <resheader name="version">
-    <value>2.0</value>
-  </resheader>
-  <resheader name="reader">
-    <value>System.Resources.ResXResourceReader, System.Windows.Forms, Version=2.0.0.0, Culture=neutral, PublicKeyToken=b77a5c561934e089</value>
-  </resheader>
-  <resheader name="writer">
-    <value>System.Resources.ResXResourceWriter, System.Windows.Forms, Version=2.0.0.0, Culture=neutral, PublicKeyToken=b77a5c561934e089</value>
-  </resheader>
-  <assembly alias="System.Windows.Forms" name="System.Windows.Forms, Version=2.0.0.0, Culture=neutral, PublicKeyToken=b77a5c561934e089" />
-  <data name="Cancel" type="System.Resources.ResXFileRef, System.Windows.Forms">
-    <value>..\Resources\Cancel.ico;System.Drawing.Bitmap, System.Drawing, Version=2.0.0.0, Culture=neutral, PublicKeyToken=b03f5f7f11d50a3a</value>
-  </data>
-  <data name="OK" type="System.Resources.ResXFileRef, System.Windows.Forms">
-    <value>..\Resources\OK.ico;System.Drawing.Bitmap, System.Drawing, Version=2.0.0.0, Culture=neutral, PublicKeyToken=b03f5f7f11d50a3a</value>
-  </data>
-</root>
\ No newline at end of file
diff --git a/src/MoBi.UI/Properties/Settings.Designer.cs b/src/MoBi.UI/Properties/Settings.Designer.cs
deleted file mode 100644
index 9932c3326..000000000
--- a/src/MoBi.UI/Properties/Settings.Designer.cs
+++ /dev/null
@@ -1,26 +0,0 @@
-//------------------------------------------------------------------------------
-// <auto-generated>
-//     This code was generated by a tool.
-//     Runtime Version:4.0.30319.42000
-//
-//     Changes to this file may cause incorrect behavior and will be lost if
-//     the code is regenerated.
-// </auto-generated>
-//------------------------------------------------------------------------------
-
-namespace MoBi.UI.Properties {
-    
-    
-    [global::System.Runtime.CompilerServices.CompilerGeneratedAttribute()]
-    [global::System.CodeDom.Compiler.GeneratedCodeAttribute("Microsoft.VisualStudio.Editors.SettingsDesigner.SettingsSingleFileGenerator", "15.3.0.0")]
-    internal sealed partial class Settings : global::System.Configuration.ApplicationSettingsBase {
-        
-        private static Settings defaultInstance = ((Settings)(global::System.Configuration.ApplicationSettingsBase.Synchronized(new Settings())));
-        
-        public static Settings Default {
-            get {
-                return defaultInstance;
-            }
-        }
-    }
-}
diff --git a/src/MoBi.UI/Properties/Settings.settings b/src/MoBi.UI/Properties/Settings.settings
deleted file mode 100644
index 39645652a..000000000
--- a/src/MoBi.UI/Properties/Settings.settings
+++ /dev/null
@@ -1,7 +0,0 @@
-<?xml version='1.0' encoding='utf-8'?>
-<SettingsFile xmlns="http://schemas.microsoft.com/VisualStudio/2004/01/settings" CurrentProfile="(Default)">
-  <Profiles>
-    <Profile Name="(Default)" />
-  </Profiles>
-  <Settings />
-</SettingsFile>
diff --git a/src/MoBi.UI/Properties/build.licx b/src/MoBi.UI/Properties/build.licx
deleted file mode 100644
index c742e85ca..000000000
--- a/src/MoBi.UI/Properties/build.licx
+++ /dev/null
@@ -1,2 +0,0 @@
-Northwoods.Go.Layout.GoLayoutForceDirected, Northwoods.Go.Layout, Version=4.1.0.2, Culture=neutral, PublicKeyToken=a4e3b7b70161cfe8
-Northwoods.Go.GoView, Northwoods.Go, Version=4.1.0.2, Culture=neutral, PublicKeyToken=a4e3b7b70161cfe8
diff --git a/src/MoBi.UI/Properties/licenses.licx b/src/MoBi.UI/Properties/licenses.licx
deleted file mode 100644
index 9c7120d12..000000000
--- a/src/MoBi.UI/Properties/licenses.licx
+++ /dev/null
@@ -1,6 +0,0 @@
-DevExpress.XtraEditors.TextEdit, DevExpress.XtraEditors.v18.2, Version=18.2.7.0, Culture=neutral, PublicKeyToken=b88d1754d700e49a
-DevExpress.XtraEditors.ButtonEdit, DevExpress.XtraEditors.v18.2, Version=18.2.7.0, Culture=neutral, PublicKeyToken=b88d1754d700e49a
-DevExpress.XtraGrid.GridControl, DevExpress.XtraGrid.v18.2, Version=18.2.7.0, Culture=neutral, PublicKeyToken=b88d1754d700e49a
-DevExpress.XtraEditors.ComboBoxEdit, DevExpress.XtraEditors.v18.2, Version=18.2.7.0, Culture=neutral, PublicKeyToken=b88d1754d700e49a
-DevExpress.XtraBars.BarManager, DevExpress.XtraBars.v18.2, Version=18.2.7.0, Culture=neutral, PublicKeyToken=b88d1754d700e49a
-DevExpress.XtraEditors.CheckEdit, DevExpress.XtraEditors.v18.2, Version=18.2.7.0, Culture=neutral, PublicKeyToken=b88d1754d700e49a
diff --git a/src/MoBi.UI/Services/ApplicationStartup.cs b/src/MoBi.UI/Services/ApplicationStartup.cs
index 629461718..61cfade7b 100644
--- a/src/MoBi.UI/Services/ApplicationStartup.cs
+++ b/src/MoBi.UI/Services/ApplicationStartup.cs
@@ -144,10 +144,10 @@ public static void InitDimensions(IContainer container)
          var configuration = container.Resolve<IMoBiConfiguration>();
          var dimFactory = container.Resolve<IMoBiDimensionFactory>();
          var persister = container.Resolve<IDimensionFactoryPersistor>();
-         persister.Load(dimFactory.BaseFactory, configuration.DimensionFilePath);
-         dimFactory.BaseFactory.AddDimension(Constants.Dimension.NO_DIMENSION);
+         persister.Load(dimFactory, configuration.DimensionFilePath);
+         dimFactory.AddDimension(Constants.Dimension.NO_DIMENSION);
          container.RegisterImplementationOf<IDimensionFactory>(dimFactory);
-         setUpDimensionMergings(dimFactory.BaseFactory);
+         setupDimensionMergings(dimFactory);
       }
 
       // because Setup cannot copy into each user profile app data, copy has to be done here
@@ -187,19 +187,19 @@ private static ICoreCalculationMethod createDefaultCalculationMethodForCategory(
          return cm;
       }
 
-      private static void setUpDimensionMergings(IDimensionFactory factory)
+      private static void setupDimensionMergings(IDimensionFactory factory)
       {
          var concentrationDimension = factory.Dimension(Constants.Dimension.MASS_CONCENTRATION);
-         var molarConcentrationDimomension = factory.Dimension(Constants.Dimension.MOLAR_CONCENTRATION);
+         var molarConcentrationDimension = factory.Dimension(Constants.Dimension.MOLAR_CONCENTRATION);
 
-         factory.AddMergingInformation(new MoBiDimensionMergingInformation<IQuantity>(concentrationDimension, molarConcentrationDimomension,
-            new MolWeightDimensionConverterForFormulaUsable(concentrationDimension, molarConcentrationDimomension)));
+         factory.AddMergingInformation(new MoBiDimensionMergingInformation<IQuantity>(concentrationDimension, molarConcentrationDimension,
+            new MolWeightDimensionConverterForFormulaUsable(concentrationDimension, molarConcentrationDimension)));
 
-         factory.AddMergingInformation(new MoBiDimensionMergingInformation<DataColumn>(concentrationDimension, molarConcentrationDimomension,
-            new ConcentrationToMolarConcentrationConverterForDataColumn(concentrationDimension, molarConcentrationDimomension)));
+         factory.AddMergingInformation(new MoBiDimensionMergingInformation<DataColumn>(concentrationDimension, molarConcentrationDimension,
+            new ConcentrationToMolarConcentrationConverterForDataColumn(concentrationDimension, molarConcentrationDimension)));
 
-         factory.AddMergingInformation(new MoBiDimensionMergingInformation<DataColumn>(molarConcentrationDimomension, concentrationDimension,
-            new MolarConcentrationToConcentrationConverterForDataColumn(molarConcentrationDimomension, concentrationDimension)));
+         factory.AddMergingInformation(new MoBiDimensionMergingInformation<DataColumn>(molarConcentrationDimension, concentrationDimension,
+            new MolarConcentrationToConcentrationConverterForDataColumn(molarConcentrationDimension, concentrationDimension)));
       }
 
       public void InitializeForStartup(Action<IContainer> registrationAction)
@@ -266,8 +266,8 @@ private static void registerCoreComponents(IContainer container)
 
       private static void registerImport(IContainer container)
       {
-         var mobiDataImprterSettings = new DataImporterSettings {Icon = ApplicationIcons.MoBi, Caption = "MoBi Data Import"};
-         container.RegisterImplementationOf(mobiDataImprterSettings);
+         var mobiDataImporterSettings = new DataImporterSettings {IconName = ApplicationIcons.MoBi.IconName, Caption = "MoBi Data Import"};
+         container.RegisterImplementationOf(mobiDataImporterSettings);
       }
 
       private static void registerPresenter(IContainer container)
@@ -282,7 +282,7 @@ private static void registerView(IContainer container)
 
       private static void registerSerializationDependencies(IContainer container)
       {
-         //create serializer repository for xml persisentence and register all available serializer
+         //create serializer repository for xml persistence and register all available serializer
          var register = new SerializerRegister();
          container.AddRegister(x => x.FromInstance(register));
          register.PerformMappingForSerializerIn(container);
diff --git a/src/MoBi.UI/UserInterfaceRegister.cs b/src/MoBi.UI/UserInterfaceRegister.cs
index 23487f9d3..79a62bae7 100644
--- a/src/MoBi.UI/UserInterfaceRegister.cs
+++ b/src/MoBi.UI/UserInterfaceRegister.cs
@@ -40,6 +40,8 @@ public void RegisterInContainer(IContainer container)
             scan.WithConvention<OSPSuiteRegistrationConvention>();
          });
 
+
+         container.AddRegister(x=>x.FromType<OSPSuite.UI.UIImporterRegister>());
          container.Register<IMoBiMainView, IShell, IMainView, MoBiMainView>(LifeStyle.Singleton);
 
          container.Register<IContainerModalView, ModalForm>(LifeStyle.Transient);
diff --git a/src/MoBi.UI/Views/CreatePKSimMoleculeView.cs b/src/MoBi.UI/Views/CreatePKSimMoleculeView.cs
index f2fa9ab47..f45bb57b9 100644
--- a/src/MoBi.UI/Views/CreatePKSimMoleculeView.cs
+++ b/src/MoBi.UI/Views/CreatePKSimMoleculeView.cs
@@ -6,6 +6,7 @@
 using MoBi.Presentation.Presenter;
 using MoBi.Presentation.Views;
 using OSPSuite.Core.Domain.UnitSystem;
+using OSPSuite.Presentation.DTO;
 using OSPSuite.Presentation.Extensions;
 using OSPSuite.UI.Controls;
 using OSPSuite.UI.Extensions;
@@ -48,7 +49,7 @@ public override void InitializeBinding()
          _gridViewBinder.AutoBind(x => x.Value)
             .WithFormat(x => x.ParameterFormatter())
             .WithCaption(AppConstants.Captions.Value)
-            .WithEditorConfiguration((activeEditor, parmeterDTO) => _comboBoxUnit.UpdateUnitsFor(activeEditor, parmeterDTO))
+            .WithEditorConfiguration((activeEditor, parameterDTO) => _comboBoxUnit.UpdateUnitsFor(activeEditor, parameterDTO))
             .WithOnValueUpdating((p, e) => setParameterValue(p, e.NewValue))
             .OnChanged += p => NotifyViewChanged();
 
diff --git a/src/MoBi.UI/Views/EditDistributedParameterView.cs b/src/MoBi.UI/Views/EditDistributedParameterView.cs
index cdb4a7845..b1e29198c 100644
--- a/src/MoBi.UI/Views/EditDistributedParameterView.cs
+++ b/src/MoBi.UI/Views/EditDistributedParameterView.cs
@@ -107,7 +107,7 @@ protected override void OnClearError(Control control)
          }
       }
 
-      private IEnumerable<IDimension> getDimensions(DistributedParameterDTO dto)
+      private IReadOnlyList<IDimension> getDimensions(DistributedParameterDTO dto)
       {
          return _presenter.GetDimensions();
       }
diff --git a/src/MoBi.UI/Views/EditParameterListView.cs b/src/MoBi.UI/Views/EditParameterListView.cs
index 00b5c9e3d..51b48f79c 100644
--- a/src/MoBi.UI/Views/EditParameterListView.cs
+++ b/src/MoBi.UI/Views/EditParameterListView.cs
@@ -16,6 +16,7 @@
 using OSPSuite.DataBinding;
 using OSPSuite.DataBinding.DevExpress;
 using OSPSuite.DataBinding.DevExpress.XtraGrid;
+using OSPSuite.Presentation.DTO;
 using OSPSuite.UI.Binders;
 using OSPSuite.UI.Controls;
 using OSPSuite.UI.Extensions;
@@ -150,7 +151,7 @@ public override void InitializeBinding()
 
          _isFixedParameterEditRepository.ButtonClick += (o, e) => OnEvent(() => onResetValue(_gridViewBinder.FocusedElement));
 
-         _pathBinder.SetVisibility(PathElement.Simulation, visible: false);
+         _pathBinder.SetVisibility(PathElementId.Simulation, visible: false);
       }
 
       private void onResetValue(ParameterDTO favoriteParameterDTO)
@@ -202,16 +203,16 @@ private void setParameterUnit(ParameterDTO parameter, Unit unit)
          OnEvent(() =>
          {
             _gridView.CloseEditor();
-            _presenter.SetParamterUnit(parameter, unit);
+            _presenter.SetParameterUnit(parameter, unit);
          });
       }
 
-      public void SetCaptions(IDictionary<PathElement, string> captions)
+      public void SetCaptions(IDictionary<PathElementId, string> captions)
       {
          captions.Each(kv => _pathBinder.SetCaption(kv.Key, kv.Value));
       }
 
-      public void SetVisibility(PathElement pathElement, bool isVisible)
+      public void SetVisibility(PathElementId pathElement, bool isVisible)
       {
          _pathBinder.SetVisibility(pathElement, isVisible);
       }
diff --git a/src/MoBi.UI/Views/EditParametersInContainerView.cs b/src/MoBi.UI/Views/EditParametersInContainerView.cs
index 892649b03..153c6a1c1 100644
--- a/src/MoBi.UI/Views/EditParametersInContainerView.cs
+++ b/src/MoBi.UI/Views/EditParametersInContainerView.cs
@@ -21,6 +21,7 @@
 using OSPSuite.DataBinding;
 using OSPSuite.DataBinding.DevExpress;
 using OSPSuite.DataBinding.DevExpress.XtraGrid;
+using OSPSuite.Presentation.DTO;
 using OSPSuite.Presentation.Extensions;
 using OSPSuite.Presentation.Views;
 using OSPSuite.UI.Binders;
@@ -221,7 +222,7 @@ private void setParameterUnit(ParameterDTO parameter, Unit unit)
          OnEvent(() =>
          {
             _gridView.CloseEditor();
-            _presenter.SetParamterUnit(parameter, unit);
+            _presenter.SetParameterUnit(parameter, unit);
          });
       }
 
diff --git a/src/MoBi.UI/Views/EditQuantityInSimulationView.cs b/src/MoBi.UI/Views/EditQuantityInSimulationView.cs
index 401327093..71c9fb2c1 100644
--- a/src/MoBi.UI/Views/EditQuantityInSimulationView.cs
+++ b/src/MoBi.UI/Views/EditQuantityInSimulationView.cs
@@ -54,7 +54,7 @@ public void BindTo(QuantityDTO quantityDTO)
 
       public bool ReadOnly
       {
-         get { return _readOnly; }
+         get => _readOnly;
          set
          {
             _readOnly = value;
@@ -64,7 +64,7 @@ public bool ReadOnly
 
       public bool AllowValueChange
       {
-         get { return LayoutVisibilityConvertor.ToBoolean(layoutControlItemValue.Visibility); }
+         get => LayoutVisibilityConvertor.ToBoolean(layoutControlItemValue.Visibility);
          set
          {
             layoutControlItemValue.Visibility = LayoutVisibilityConvertor.FromBoolean(value);
diff --git a/src/MoBi.UI/Views/ParameterStartValuesView.cs b/src/MoBi.UI/Views/ParameterStartValuesView.cs
index 4df5d70cd..6ab4a588d 100644
--- a/src/MoBi.UI/Views/ParameterStartValuesView.cs
+++ b/src/MoBi.UI/Views/ParameterStartValuesView.cs
@@ -40,7 +40,7 @@ protected override void DoInitializeBinding()
       {
          _unitControl.ParameterUnitSet += setParameterUnit;
 
-         _dimensionComboBoxRepository.FillComboBoxRepositoryWith(_dimensionFactory.Dimensions);
+         _dimensionComboBoxRepository.FillComboBoxRepositoryWith(_dimensionFactory.DimensionsSortedByName);
 
          var colName = _gridViewBinder.AutoBind(dto => dto.Name)
             .WithCaption(AppConstants.Captions.ParameterName).WithOnValueUpdating((o,e) => OnEvent(() => OnNameSet(o,e)));
diff --git a/src/MoBi.UI/Views/SolverMessageView.cs b/src/MoBi.UI/Views/SolverMessageView.cs
index 0f3a544f6..fd81624b5 100644
--- a/src/MoBi.UI/Views/SolverMessageView.cs
+++ b/src/MoBi.UI/Views/SolverMessageView.cs
@@ -1,10 +1,10 @@
 using System.Collections.Generic;
 using MoBi.Presentation.Presenter;
 using MoBi.Presentation.Views;
-using OSPSuite.Core.Domain;
 using OSPSuite.DataBinding.DevExpress;
 using OSPSuite.DataBinding.DevExpress.XtraGrid;
 using OSPSuite.Presentation.Views;
+using OSPSuite.SimModel;
 using OSPSuite.UI.Views;
 
 namespace MoBi.UI.Views
diff --git a/src/MoBi.UI/Views/ValueEdit.cs b/src/MoBi.UI/Views/ValueEdit.cs
index dd3a4aa67..c6b0749e9 100644
--- a/src/MoBi.UI/Views/ValueEdit.cs
+++ b/src/MoBi.UI/Views/ValueEdit.cs
@@ -4,6 +4,7 @@
 using DevExpress.XtraEditors.DXErrorProvider;
 
 using MoBi.Presentation.DTO;
+using OSPSuite.Core.Domain.Services;
 using OSPSuite.Core.Domain.UnitSystem;
 using OSPSuite.UI.Controls;
 
@@ -38,7 +39,7 @@ public override void InitializeBinding()
          _screenBinder = new ScreenBinder<ValueEditDTO>();
 
          _screenBinder.Bind(p => p.Value)
-            .To(tbValue).OnValueUpdating += (o, e) => ValueChanged(o, e.NewValue);
+            .To(tbValue).OnValueUpdating += onValueUpdating;
 
          _screenBinder.Bind(p => p.DisplayUnit).To(cbUnit)
             .WithValues(p => p.Dimension.Units)
@@ -51,11 +52,18 @@ public override void InitializeBinding()
          tbValue.EnterMoveNextControl = true;
       }
 
-      public override bool HasError
+      private void onValueUpdating(ValueEditDTO dto, PropertyValueSetEventArgs<double> e)
       {
-         get { return _screenBinder.HasError; }
+         // Some artifact with this control when values have a lot of digits could lead to an event being raised even though nothing has changed.
+         // This should be fixed in OSPSuite.DataBinding but we'll be done at another time
+         if (ValueComparer.AreValuesEqual(e.OldValue, e.NewValue))
+            return;
+
+         ValueChanged(dto, e.NewValue);
       }
 
+      public override bool HasError => _screenBinder.HasError;
+
       public void ValidateControl()
       {
          _screenBinder.Validate();
@@ -63,8 +71,8 @@ public void ValidateControl()
 
       public string ToolTip
       {
-         set { tbValue.ToolTip = value; }
-         get { return tbValue.ToolTip; }
+         set => tbValue.ToolTip = value;
+         get => tbValue.ToolTip;
       }
 
       public void SetError(string errorMessage)
diff --git a/src/MoBi.UI/app.config b/src/MoBi.UI/app.config
index ef6a30b70..94d16da7c 100644
--- a/src/MoBi.UI/app.config
+++ b/src/MoBi.UI/app.config
@@ -3,121 +3,9 @@
   <runtime>
     <assemblyBinding xmlns="urn:schemas-microsoft-com:asm.v1">
       <dependentAssembly>
-        <assemblyIdentity name="DevExpress.Utils.v18.2" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.Data.v18.2" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="System.Windows.Forms" publicKeyToken="b77a5c561934e089" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-4.0.0.0" newVersion="4.0.0.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.XtraTreeList.v18.2" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.XtraEditors.v18.2" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.XtraBars.v18.2" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.XtraGrid.v18.2" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.XtraCharts.v18.2.UI" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.XtraCharts.v18.2" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.XtraPivotGrid.v18.2" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.PivotGrid.v18.2.Core" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.RichEdit.v18.2.Core" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.XtraRichEdit.v18.2" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.XtraRichEdit.v18.2.Extensions" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.Charts.v18.2.Core" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.Office.v18.2.Core" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.BonusSkins.v18.2" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.XtraLayout.v18.2" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="MPFitLib" publicKeyToken="be1b3c0b5819660a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-1.1.0.0" newVersion="1.1.0.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="ICSharpCode.SharpZipLib" publicKeyToken="1b03e6acf1164f73" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-0.86.0.518" newVersion="0.86.0.518" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="System.Data.SQLite" publicKeyToken="db937bc2d44ff139" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-1.0.110.0" newVersion="1.0.110.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="SX" publicKeyToken="882b9c044052e7f6" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-2.7.0.9" newVersion="2.7.0.9" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="Northwoods.Go" publicKeyToken="a4e3b7b70161cfe8" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-4.1.0.2" newVersion="4.1.0.2" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="Northwoods.Go.Xml" publicKeyToken="a4e3b7b70161cfe8" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-4.1.0.2" newVersion="4.1.0.2" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="Northwoods.Go.Layout" publicKeyToken="a4e3b7b70161cfe8" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-4.1.0.2" newVersion="4.1.0.2" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="NHibernate" publicKeyToken="aa95f207798dfdb4" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-5.2.0.0" newVersion="5.2.0.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="System.ValueTuple" publicKeyToken="cc7b13ffcd2ddd51" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-4.0.2.0" newVersion="4.0.2.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="Iesi.Collections" publicKeyToken="aa95f207798dfdb4" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-4.0.0.4000" newVersion="4.0.0.4000" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="Newtonsoft.Json" publicKeyToken="30ad4fe6b2a6aeed" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-10.0.0.0" newVersion="10.0.0.0" />
+        <assemblyIdentity name="nunit.framework" publicKeyToken="2638cd05610744eb" culture="neutral" />
+        <bindingRedirect oldVersion="0.0.0.0-3.12.0.0" newVersion="3.12.0.0" />
       </dependentAssembly>
     </assemblyBinding>
   </runtime>
-<startup><supportedRuntime version="v4.0" sku=".NETFramework,Version=v4.6.2" /></startup></configuration>
+</configuration>
\ No newline at end of file
diff --git a/src/MoBi.UI/packages.config b/src/MoBi.UI/packages.config
index 28ae2445e..9095f9023 100644
--- a/src/MoBi.UI/packages.config
+++ b/src/MoBi.UI/packages.config
@@ -2,12 +2,12 @@
 <packages>
   <package id="Antlr3.Runtime" version="3.5.1" targetFramework="net462" />
   <package id="Castle.Core" version="4.3.1" targetFramework="net462" />
-  <package id="Castle.Windsor" version="4.1.1" targetFramework="net462" />
+  <package id="Castle.Windsor" version="5.0.1" targetFramework="net472" />
   <package id="csmpfit" version="1.1.1" targetFramework="net462" />
   <package id="Dapper" version="1.60.6" targetFramework="net462" />
   <package id="FluentNHibernate" version="2.1.2" targetFramework="net462" />
   <package id="Iesi.Collections" version="4.0.4" targetFramework="net462" />
-  <package id="MathNet.Numerics" version="4.7.0" targetFramework="net462" />
+  <package id="MathNet.Numerics" version="4.9.0" targetFramework="net472" />
   <package id="Microsoft.Extensions.Configuration" version="2.2.0" targetFramework="net462" />
   <package id="Microsoft.Extensions.Configuration.Abstractions" version="2.2.0" targetFramework="net462" />
   <package id="Microsoft.Extensions.Configuration.Binder" version="2.2.0" targetFramework="net462" />
@@ -16,33 +16,38 @@
   <package id="Microsoft.Extensions.Logging.Abstractions" version="2.2.0" targetFramework="net462" />
   <package id="Microsoft.Extensions.Options" version="2.2.0" targetFramework="net462" />
   <package id="Microsoft.Extensions.Primitives" version="2.2.0" targetFramework="net462" />
-  <package id="Newtonsoft.Json" version="12.0.1" targetFramework="net462" />
+  <package id="Newtonsoft.Json" version="12.0.2" targetFramework="net472" />
   <package id="NHibernate" version="5.2.5" targetFramework="net462" />
-  <package id="Northwoods.GoWin" version="5.2.0" targetFramework="net462" />
-  <package id="OSPSuite.Assets" version="8.0.4" targetFramework="net462" />
-  <package id="OSPSuite.Core" version="8.0.4" targetFramework="net462" />
+  <package id="Northwoods.GoWin" version="5.2.0" targetFramework="net472" />
+  <package id="OSPSuite.Assets" version="9.0.34" targetFramework="net472" />
+  <package id="OSPSuite.Assets.Images" version="9.0.34" targetFramework="net472" />
+  <package id="OSPSuite.Core" version="9.0.34" targetFramework="net472" />
   <package id="OSPSuite.DataBinding" version="2.3.0.3" targetFramework="net462" />
   <package id="OSPSuite.DataBinding.DevExpress" version="3.0.0.3" targetFramework="net462" />
   <package id="OSPSuite.DevExpress" version="18.2.7" targetFramework="net462" />
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-  <package id="OSPSuite.TeXReporting" version="2.1.1.9" targetFramework="net462" />
-  <package id="OSPSuite.UI" version="8.0.4" targetFramework="net462" />
-  <package id="OSPSuite.Utility" version="3.0.1.7" targetFramework="net462" />
+  <package id="OSPSuite.FuncParser" version="4.0.0.42" targetFramework="net472" />
+  <package id="OSPSuite.Infrastructure" version="9.0.34" targetFramework="net472" />
+  <package id="OSPSuite.Infrastructure.Castle" version="9.0.34" targetFramework="net472" />
+  <package id="OSPSuite.Presentation" version="9.0.34" targetFramework="net472" />
+  <package id="OSPSuite.Presentation.Importer" version="9.0.34" targetFramework="net472" />
+  <package id="OSPSuite.Serializer" version="3.0.0.1" targetFramework="net472" />
+  <package id="OSPSuite.SimModel" version="4.0.0.29" targetFramework="net472" />
+  <package id="OSPSuite.SmartXLS" version="2.7.2.9" targetFramework="net472" />
+  <package id="OSPSuite.TeXReporting" version="3.0.0.4" targetFramework="net472" />
+  <package id="OSPSuite.UI" version="9.0.34" targetFramework="net472" />
+  <package id="OSPSuite.UI.Importer" version="9.0.34" targetFramework="net472" />
+  <package id="OSPSuite.Utility" version="4.0.0.1" targetFramework="net472" />
   <package id="Remotion.Linq" version="2.2.0" targetFramework="net462" />
   <package id="Remotion.Linq.EagerFetching" version="2.2.0" targetFramework="net462" />
-  <package id="SharpZipLib" version="1.1.0" targetFramework="net462" />
+  <package id="SharpZipLib" version="1.2.0" targetFramework="net472" />
   <package id="System.Buffers" version="4.4.0" targetFramework="net462" />
   <package id="System.ComponentModel.Annotations" version="4.5.0" targetFramework="net462" />
-  <package id="System.Data.SQLite.Core" version="1.0.110.0" targetFramework="net462" />
+  <package id="System.Data.SQLite.Core" version="1.0.111.0" targetFramework="net472" />
+  <package id="System.Drawing.Common" version="4.5.1" targetFramework="net472" />
   <package id="System.Memory" version="4.5.1" targetFramework="net462" />
   <package id="System.Numerics.Vectors" version="4.4.0" targetFramework="net462" />
   <package id="System.Runtime.CompilerServices.Unsafe" version="4.5.1" targetFramework="net462" />
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   <package id="WindowsAPICodePack-Core" version="1.1.2" targetFramework="net462" />
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 </packages>
\ No newline at end of file
diff --git a/src/MoBi/MoBi.csproj b/src/MoBi/MoBi.csproj
index e451c911a..9b1e8a7ff 100644
--- a/src/MoBi/MoBi.csproj
+++ b/src/MoBi/MoBi.csproj
@@ -1,282 +1,91 @@
-<?xml version="1.0" encoding="utf-8"?>
-<Project ToolsVersion="12.0" DefaultTargets="Build" xmlns="http://schemas.microsoft.com/developer/msbuild/2003">
+<Project Sdk="Microsoft.NET.Sdk">
+
   <PropertyGroup>
-    <Configuration Condition=" '$(Configuration)' == '' ">Debug</Configuration>
-    <Platform Condition=" '$(Platform)' == '' ">AnyCPU</Platform>
-    <ProductVersion>9.0.21022</ProductVersion>
-    <SchemaVersion>2.0</SchemaVersion>
-    <ProjectGuid>{B831E5E2-431A-4627-B58C-3CE3F5002E42}</ProjectGuid>
+    <TargetFramework>net472</TargetFramework>
     <OutputType>WinExe</OutputType>
-    <AppDesignerFolder>Properties</AppDesignerFolder>
-    <RootNamespace>MoBi</RootNamespace>
-    <AssemblyName>MoBi</AssemblyName>
-    <AutoGenerateBindingRedirects>true</AutoGenerateBindingRedirects>
-    <TargetFrameworkVersion>v4.6.2</TargetFrameworkVersion>
-    <FileAlignment>512</FileAlignment>
-    <SccProjectName>
-    </SccProjectName>
-    <SccLocalPath>
-    </SccLocalPath>
-    <SccAuxPath>
-    </SccAuxPath>
-    <SccProvider>
-    </SccProvider>
-    <StartupObject>
-    </StartupObject>
-    <IsWebBootstrapper>false</IsWebBootstrapper>
+    <Version>9.0.0</Version>
+    <PackageVersion>9.0.0</PackageVersion>
+    <AssemblyVersion>9.0.0</AssemblyVersion>
+    <FileVersion>9.0.0</FileVersion>
+    <InformationalVersion>9.0.0</InformationalVersion>
+    <GenerateAssemblyProductAttribute>false</GenerateAssemblyProductAttribute>
+    <GenerateAssemblyCompanyAttribute>false</GenerateAssemblyCompanyAttribute>
+    <Authors>Open-Systems-Pharmacology</Authors>
+    <PackageLicenseFile>LICENSE</PackageLicenseFile>
+    <DocumentationFile>bin\$(Configuration)\$(TargetFramework)\$(AssemblyName).xml</DocumentationFile>
+    <NoWarn>1591, 3246</NoWarn>
     <ApplicationIcon>MoBi.ico</ApplicationIcon>
-    <StartupObject>
-    </StartupObject>
-    <FileUpgradeFlags>
-    </FileUpgradeFlags>
-    <UpgradeBackupLocation>
-    </UpgradeBackupLocation>
-    <OldToolsVersion>3.5</OldToolsVersion>
-    <TargetFrameworkProfile />
-    <PublishUrl>publish\</PublishUrl>
-    <Install>true</Install>
-    <InstallFrom>Disk</InstallFrom>
-    <UpdateEnabled>false</UpdateEnabled>
-    <UpdateMode>Foreground</UpdateMode>
-    <UpdateInterval>7</UpdateInterval>
-    <UpdateIntervalUnits>Days</UpdateIntervalUnits>
-    <UpdatePeriodically>false</UpdatePeriodically>
-    <UpdateRequired>false</UpdateRequired>
-    <MapFileExtensions>true</MapFileExtensions>
-    <ApplicationRevision>0</ApplicationRevision>
-    <ApplicationVersion>1.0.0.%2a</ApplicationVersion>
-    <UseApplicationTrust>false</UseApplicationTrust>
-    <BootstrapperEnabled>true</BootstrapperEnabled>
   </PropertyGroup>
-  <PropertyGroup Condition=" '$(Configuration)|$(Platform)' == 'Debug|AnyCPU' ">
-    <DebugSymbols>true</DebugSymbols>
-    <DebugType>full</DebugType>
-    <Optimize>false</Optimize>
-    <OutputPath>bin\Debug\</OutputPath>
-    <DefineConstants>DEBUG;TRACE</DefineConstants>
-    <ErrorReport>prompt</ErrorReport>
-    <WarningLevel>4</WarningLevel>
+
+  <PropertyGroup Condition="'$(Configuration)|$(Platform)'=='Debug|AnyCPU'">
     <PlatformTarget>x64</PlatformTarget>
-    <Prefer32Bit>false</Prefer32Bit>
-  </PropertyGroup>
-  <PropertyGroup Condition=" '$(Configuration)|$(Platform)' == 'Release|AnyCPU' ">
-    <DebugType>pdbonly</DebugType>
-    <Optimize>true</Optimize>
-    <OutputPath>bin\Release\</OutputPath>
-    <DefineConstants>TRACE</DefineConstants>
-    <ErrorReport>prompt</ErrorReport>
-    <WarningLevel>4</WarningLevel>
-    <Prefer32Bit>false</Prefer32Bit>
   </PropertyGroup>
+
   <ItemGroup>
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-      <HintPath>..\..\packages\OSPSuite.DevExpress.Presentation.18.2.7\lib\net45\DevExpress.Data.v18.2.dll</HintPath>
-    </Reference>
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-    <Reference Include="System.Deployment" />
-    <Reference Include="System.Drawing" />
-    <Reference Include="System.Windows.Forms" />
-    <Reference Include="System.Xml" />
+    <Compile Include="..\..\SolutionInfo.cs" Link="Properties\SolutionInfo.cs" />
   </ItemGroup>
+
+ 
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-      <Link>Properties\SolutionInfo.cs</Link>
-    </Compile>
-    <Compile Include="Program.cs" />
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-    </None>
-    <None Include="..\Data\Templates\Standard Molecule.pkml">
-      <Link>Standard Molecule.pkml</Link>
+    <Content Include="..\..\dimensions\OSPSuite.Dimensions.xml" Link="OSPSuite.Dimensions.xml">
       <CopyToOutputDirectory>PreserveNewest</CopyToOutputDirectory>
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-    <None Include="app.config">
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-    </Compile>
-  </ItemGroup>
-  <ItemGroup>
-    <None Include="..\..\dimensions\OSPSuite.Dimensions.xml">
-      <Link>OSPSuite.Dimensions.xml</Link>
+    </Content>
+    <Content Include="..\..\pkparameters\OSPSuite.PKParameters.xml" Link="OSPSuite.PKParameters.xml">
       <CopyToOutputDirectory>PreserveNewest</CopyToOutputDirectory>
-    </None>
-    <None Include="..\..\pkparameters\OSPSuite.PKParameters.xml">
-      <Link>OSPSuite.PKParameters.xml</Link>
+    </Content>
+    <Content Include="$(PkgOSPSuite_FuncParser)\OSPSuite.FuncParserNative\bin\native\x64\Release\OSPSuite.FuncParserNative.dll" Link="OSPSuite.FuncParserNative.dll">
       <CopyToOutputDirectory>PreserveNewest</CopyToOutputDirectory>
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-      <Link>OSPSuite.SimModelSolver_CVODES.dll</Link>
+    </Content>
+    <Content Include="$(PkgOSPSuite_SimModel)\OSPSuite.SimModelNative\bin\native\x64\Release\OSPSuite.SimModelNative.dll" Link="OSPSuite.SimModelNative.dll">
       <CopyToOutputDirectory>PreserveNewest</CopyToOutputDirectory>
     </Content>
-    <Content Include="..\..\packages\System.Data.SQLite.Core.1.0.110.0\build\net46\x64\SQLite.Interop.dll">
-      <Link>SQLite.Interop.dll</Link>
+    <Content Include="$(PkgOSPSuite_SimModelSolver_CVODES)\OSPSuite.SimModelSolver_CVODES\bin\native\x64\Release\OSPSuite.SimModelSolver_CVODES.dll" Link="OSPSuite.SimModelSolver_CVODES.dll">
       <CopyToOutputDirectory>PreserveNewest</CopyToOutputDirectory>
     </Content>
-    <Content Include="..\..\pre\libsbmlcs.dll">
-      <Link>libsbmlcs.dll</Link>
+    <Content Include="$(PkgSystem_Data_SQLite_Core)\build\net46\x64\SQLite.Interop.dll" Link="SQLite.Interop.dll">
       <CopyToOutputDirectory>PreserveNewest</CopyToOutputDirectory>
     </Content>
-    <Content Include="..\Data\GroupRepository.xml">
-      <Link>GroupRepository.xml</Link>
+    <Content Include="$(PkgOSPSuite_Presentation)\OSPSuite.Presentation\**">
       <CopyToOutputDirectory>PreserveNewest</CopyToOutputDirectory>
     </Content>
-    <Content Include="MoBi.ico">
-      <CopyToOutputDirectory>Always</CopyToOutputDirectory>
+    <Content Include="$(PkgOSPSuite_TeXReporting)\OSPSuite.TeXReporting\**">
+      <CopyToOutputDirectory>PreserveNewest</CopyToOutputDirectory>
     </Content>
   </ItemGroup>
+
   <ItemGroup>
-    <ProjectReference Include="..\MoBi.Core\MoBi.Core.csproj">
-      <Project>{2DBF50BE-A749-421C-B526-8BDA31CFE7B3}</Project>
-      <Name>MoBi.Core</Name>
-    </ProjectReference>
-    <ProjectReference Include="..\MoBi.Engine\MoBi.Engine.csproj">
-      <Project>{15ed932c-edec-407b-91d9-7bcb8e7f95f5}</Project>
-      <Name>MoBi.Engine</Name>
-    </ProjectReference>
-    <ProjectReference Include="..\MoBi.Presentation\MoBi.Presentation.csproj">
-      <Project>{B4C86DCA-8877-4400-8088-2401EE65B403}</Project>
-      <Name>MoBi.Presentation</Name>
-    </ProjectReference>
-    <ProjectReference Include="..\MoBi.UI\MoBi.UI.csproj">
-      <Project>{DE743812-F444-42E2-B72D-CF298933E2BA}</Project>
-      <Name>MoBi.UI</Name>
-    </ProjectReference>
+    <Folder Include="Properties\" />
   </ItemGroup>
+
   <ItemGroup>
-    <BootstrapperPackage Include="Microsoft.Net.Client.3.5">
-      <Visible>False</Visible>
-      <ProductName>.NET Framework 3.5 SP1 Client Profile</ProductName>
-      <Install>false</Install>
-    </BootstrapperPackage>
-    <BootstrapperPackage Include="Microsoft.Net.Framework.2.0">
-      <Visible>False</Visible>
-      <ProductName>.NET Framework 2.0 %28x86%29</ProductName>
-      <Install>false</Install>
-    </BootstrapperPackage>
-    <BootstrapperPackage Include="Microsoft.Net.Framework.3.0">
-      <Visible>False</Visible>
-      <ProductName>.NET Framework 3.0 %28x86%29</ProductName>
-      <Install>false</Install>
-    </BootstrapperPackage>
-    <BootstrapperPackage Include="Microsoft.Net.Framework.3.5">
-      <Visible>False</Visible>
-      <ProductName>.NET Framework 3.5</ProductName>
-      <Install>true</Install>
-    </BootstrapperPackage>
-    <BootstrapperPackage Include="Microsoft.Net.Framework.3.5.SP1">
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-      <ProductName>.NET Framework 3.5 SP1</ProductName>
-      <Install>false</Install>
-    </BootstrapperPackage>
-    <BootstrapperPackage Include="Microsoft.Windows.Installer.3.1">
-      <Visible>False</Visible>
-      <ProductName>Windows Installer 3.1</ProductName>
-      <Install>true</Install>
-    </BootstrapperPackage>
+    <None Include="..\..\LICENSE">
+      <Pack>True</Pack>
+      <PackagePath></PackagePath>
+    </None>
+    <None Include="..\..\pre\libsbmlcs.dll" Link="libsbmlcs.dll">
+      <CopyToOutputDirectory>PreserveNewest</CopyToOutputDirectory>
+    </None>
+  </ItemGroup>
+
+  <ItemGroup>
+    <PackageReference Include="OSPSuite.Core" Version="9.0.137" />
+    <PackageReference Include="OSPSuite.DevExpress" Version="19.2.4.1" />
+    <PackageReference Include="OSPSuite.FuncParser" Version="4.0.0.50" GeneratePathProperty="true" />
+    <PackageReference Include="OSPSuite.SimModel" Version="4.0.0.42" GeneratePathProperty="true" />
+    <PackageReference Include="OSPSuite.SimModelSolver_CVODES" Version="4.1.0.8" GeneratePathProperty="true" />
+    <PackageReference Include="System.Data.SQLite.Core" Version="1.0.112" GeneratePathProperty="true" />
+    <PackageReference Include="OSPSuite.Presentation" Version="9.0.137" GeneratePathProperty="true" />
+    <PackageReference Include="OSPSuite.TeXReporting" Version="3.0.0.4" GeneratePathProperty="true" />
+
+  </ItemGroup>
+
+  <ItemGroup>
+    <ProjectReference Include="..\MoBi.Engine\MoBi.Engine.csproj" />
+    <ProjectReference Include="..\MoBi.UI\MoBi.UI.csproj" />
+  </ItemGroup>
+
+  <ItemGroup>
+    <Reference Include="Microsoft.VisualBasic" />
+    <Reference Include="System.Windows.Forms" />
   </ItemGroup>
-  <Import Project="$(MSBuildToolsPath)\Microsoft.CSharp.targets" />
-  <PropertyGroup>
-    <PostBuildEvent>
-    </PostBuildEvent>
-  </PropertyGroup>
-  <!-- To modify your build process, add your task inside one of the targets below and uncomment it. 
-       Other similar extension points exist, see Microsoft.Common.targets.
-  <Target Name="BeforeBuild">
-  </Target>
-  <Target Name="AfterBuild">
-  </Target>
-  -->
 </Project>
\ No newline at end of file
diff --git a/src/MoBi/Properties/AssemblyInfo.cs b/src/MoBi/Properties/AssemblyInfo.cs
deleted file mode 100644
index f549bbc77..000000000
--- a/src/MoBi/Properties/AssemblyInfo.cs
+++ /dev/null
@@ -1,10 +0,0 @@
-using System.Reflection;
-using System.Runtime.CompilerServices;
-using System.Runtime.InteropServices;
-
-// General Information about an assembly is controlled through the following 
-// set of attributes. Change these attribute values to modify the information
-// associated with an assembly.
-[assembly: AssemblyTitle("MoBi")]
-
-
diff --git a/src/MoBi/Properties/Resources.Designer.cs b/src/MoBi/Properties/Resources.Designer.cs
deleted file mode 100644
index 94a728821..000000000
--- a/src/MoBi/Properties/Resources.Designer.cs
+++ /dev/null
@@ -1,63 +0,0 @@
-//------------------------------------------------------------------------------
-// <auto-generated>
-//     This code was generated by a tool.
-//     Runtime Version:4.0.30319.42000
-//
-//     Changes to this file may cause incorrect behavior and will be lost if
-//     the code is regenerated.
-// </auto-generated>
-//------------------------------------------------------------------------------
-
-namespace MoBi.Properties {
-    using System;
-    
-    
-    /// <summary>
-    ///   A strongly-typed resource class, for looking up localized strings, etc.
-    /// </summary>
-    // This class was auto-generated by the StronglyTypedResourceBuilder
-    // class via a tool like ResGen or Visual Studio.
-    // To add or remove a member, edit your .ResX file then rerun ResGen
-    // with the /str option, or rebuild your VS project.
-    [global::System.CodeDom.Compiler.GeneratedCodeAttribute("System.Resources.Tools.StronglyTypedResourceBuilder", "15.0.0.0")]
-    [global::System.Diagnostics.DebuggerNonUserCodeAttribute()]
-    [global::System.Runtime.CompilerServices.CompilerGeneratedAttribute()]
-    internal class Resources {
-        
-        private static global::System.Resources.ResourceManager resourceMan;
-        
-        private static global::System.Globalization.CultureInfo resourceCulture;
-        
-        [global::System.Diagnostics.CodeAnalysis.SuppressMessageAttribute("Microsoft.Performance", "CA1811:AvoidUncalledPrivateCode")]
-        internal Resources() {
-        }
-        
-        /// <summary>
-        ///   Returns the cached ResourceManager instance used by this class.
-        /// </summary>
-        [global::System.ComponentModel.EditorBrowsableAttribute(global::System.ComponentModel.EditorBrowsableState.Advanced)]
-        internal static global::System.Resources.ResourceManager ResourceManager {
-            get {
-                if (object.ReferenceEquals(resourceMan, null)) {
-                    global::System.Resources.ResourceManager temp = new global::System.Resources.ResourceManager("MoBi.Properties.Resources", typeof(Resources).Assembly);
-                    resourceMan = temp;
-                }
-                return resourceMan;
-            }
-        }
-        
-        /// <summary>
-        ///   Overrides the current thread's CurrentUICulture property for all
-        ///   resource lookups using this strongly typed resource class.
-        /// </summary>
-        [global::System.ComponentModel.EditorBrowsableAttribute(global::System.ComponentModel.EditorBrowsableState.Advanced)]
-        internal static global::System.Globalization.CultureInfo Culture {
-            get {
-                return resourceCulture;
-            }
-            set {
-                resourceCulture = value;
-            }
-        }
-    }
-}
diff --git a/src/MoBi/Properties/Resources.resx b/src/MoBi/Properties/Resources.resx
deleted file mode 100644
index af7dbebba..000000000
--- a/src/MoBi/Properties/Resources.resx
+++ /dev/null
@@ -1,117 +0,0 @@
-<?xml version="1.0" encoding="utf-8"?>
-<root>
-  <!-- 
-    Microsoft ResX Schema 
-    
-    Version 2.0
-    
-    The primary goals of this format is to allow a simple XML format 
-    that is mostly human readable. The generation and parsing of the 
-    various data types are done through the TypeConverter classes 
-    associated with the data types.
-    
-    Example:
-    
-    ... ado.net/XML headers & schema ...
-    <resheader name="resmimetype">text/microsoft-resx</resheader>
-    <resheader name="version">2.0</resheader>
-    <resheader name="reader">System.Resources.ResXResourceReader, System.Windows.Forms, ...</resheader>
-    <resheader name="writer">System.Resources.ResXResourceWriter, System.Windows.Forms, ...</resheader>
-    <data name="Name1"><value>this is my long string</value><comment>this is a comment</comment></data>
-    <data name="Color1" type="System.Drawing.Color, System.Drawing">Blue</data>
-    <data name="Bitmap1" mimetype="application/x-microsoft.net.object.binary.base64">
-        <value>[base64 mime encoded serialized .NET Framework object]</value>
-    </data>
-    <data name="Icon1" type="System.Drawing.Icon, System.Drawing" mimetype="application/x-microsoft.net.object.bytearray.base64">
-        <value>[base64 mime encoded string representing a byte array form of the .NET Framework object]</value>
-        <comment>This is a comment</comment>
-    </data>
-                
-    There are any number of "resheader" rows that contain simple 
-    name/value pairs.
-    
-    Each data row contains a name, and value. The row also contains a 
-    type or mimetype. Type corresponds to a .NET class that support 
-    text/value conversion through the TypeConverter architecture. 
-    Classes that don't support this are serialized and stored with the 
-    mimetype set.
-    
-    The mimetype is used for serialized objects, and tells the 
-    ResXResourceReader how to depersist the object. This is currently not 
-    extensible. For a given mimetype the value must be set accordingly:
-    
-    Note - application/x-microsoft.net.object.binary.base64 is the format 
-    that the ResXResourceWriter will generate, however the reader can 
-    read any of the formats listed below.
-    
-    mimetype: application/x-microsoft.net.object.binary.base64
-    value   : The object must be serialized with 
-            : System.Serialization.Formatters.Binary.BinaryFormatter
-            : and then encoded with base64 encoding.
-    
-    mimetype: application/x-microsoft.net.object.soap.base64
-    value   : The object must be serialized with 
-            : System.Runtime.Serialization.Formatters.Soap.SoapFormatter
-            : and then encoded with base64 encoding.
-
-    mimetype: application/x-microsoft.net.object.bytearray.base64
-    value   : The object must be serialized into a byte array 
-            : using a System.ComponentModel.TypeConverter
-            : and then encoded with base64 encoding.
-    -->
-  <xsd:schema id="root" xmlns="" xmlns:xsd="http://www.w3.org/2001/XMLSchema" xmlns:msdata="urn:schemas-microsoft-com:xml-msdata">
-    <xsd:element name="root" msdata:IsDataSet="true">
-      <xsd:complexType>
-        <xsd:choice maxOccurs="unbounded">
-          <xsd:element name="metadata">
-            <xsd:complexType>
-              <xsd:sequence>
-                <xsd:element name="value" type="xsd:string" minOccurs="0" />
-              </xsd:sequence>
-              <xsd:attribute name="name" type="xsd:string" />
-              <xsd:attribute name="type" type="xsd:string" />
-              <xsd:attribute name="mimetype" type="xsd:string" />
-            </xsd:complexType>
-          </xsd:element>
-          <xsd:element name="assembly">
-            <xsd:complexType>
-              <xsd:attribute name="alias" type="xsd:string" />
-              <xsd:attribute name="name" type="xsd:string" />
-            </xsd:complexType>
-          </xsd:element>
-          <xsd:element name="data">
-            <xsd:complexType>
-              <xsd:sequence>
-                <xsd:element name="value" type="xsd:string" minOccurs="0" msdata:Ordinal="1" />
-                <xsd:element name="comment" type="xsd:string" minOccurs="0" msdata:Ordinal="2" />
-              </xsd:sequence>
-              <xsd:attribute name="name" type="xsd:string" msdata:Ordinal="1" />
-              <xsd:attribute name="type" type="xsd:string" msdata:Ordinal="3" />
-              <xsd:attribute name="mimetype" type="xsd:string" msdata:Ordinal="4" />
-            </xsd:complexType>
-          </xsd:element>
-          <xsd:element name="resheader">
-            <xsd:complexType>
-              <xsd:sequence>
-                <xsd:element name="value" type="xsd:string" minOccurs="0" msdata:Ordinal="1" />
-              </xsd:sequence>
-              <xsd:attribute name="name" type="xsd:string" use="required" />
-            </xsd:complexType>
-          </xsd:element>
-        </xsd:choice>
-      </xsd:complexType>
-    </xsd:element>
-  </xsd:schema>
-  <resheader name="resmimetype">
-    <value>text/microsoft-resx</value>
-  </resheader>
-  <resheader name="version">
-    <value>2.0</value>
-  </resheader>
-  <resheader name="reader">
-    <value>System.Resources.ResXResourceReader, System.Windows.Forms, Version=2.0.0.0, Culture=neutral, PublicKeyToken=b77a5c561934e089</value>
-  </resheader>
-  <resheader name="writer">
-    <value>System.Resources.ResXResourceWriter, System.Windows.Forms, Version=2.0.0.0, Culture=neutral, PublicKeyToken=b77a5c561934e089</value>
-  </resheader>
-</root>
\ No newline at end of file
diff --git a/src/MoBi/Properties/Settings.Designer.cs b/src/MoBi/Properties/Settings.Designer.cs
deleted file mode 100644
index a5180e7b5..000000000
--- a/src/MoBi/Properties/Settings.Designer.cs
+++ /dev/null
@@ -1,26 +0,0 @@
-//------------------------------------------------------------------------------
-// <auto-generated>
-//     This code was generated by a tool.
-//     Runtime Version:4.0.30319.42000
-//
-//     Changes to this file may cause incorrect behavior and will be lost if
-//     the code is regenerated.
-// </auto-generated>
-//------------------------------------------------------------------------------
-
-namespace MoBi.Properties {
-    
-    
-    [global::System.Runtime.CompilerServices.CompilerGeneratedAttribute()]
-    [global::System.CodeDom.Compiler.GeneratedCodeAttribute("Microsoft.VisualStudio.Editors.SettingsDesigner.SettingsSingleFileGenerator", "15.3.0.0")]
-    internal sealed partial class Settings : global::System.Configuration.ApplicationSettingsBase {
-        
-        private static Settings defaultInstance = ((Settings)(global::System.Configuration.ApplicationSettingsBase.Synchronized(new Settings())));
-        
-        public static Settings Default {
-            get {
-                return defaultInstance;
-            }
-        }
-    }
-}
diff --git a/src/MoBi/Properties/Settings.settings b/src/MoBi/Properties/Settings.settings
deleted file mode 100644
index 39645652a..000000000
--- a/src/MoBi/Properties/Settings.settings
+++ /dev/null
@@ -1,7 +0,0 @@
-<?xml version='1.0' encoding='utf-8'?>
-<SettingsFile xmlns="http://schemas.microsoft.com/VisualStudio/2004/01/settings" CurrentProfile="(Default)">
-  <Profiles>
-    <Profile Name="(Default)" />
-  </Profiles>
-  <Settings />
-</SettingsFile>
diff --git a/src/MoBi/app.config b/src/MoBi/app.config
index ed8d8aee2..76df683cd 100644
--- a/src/MoBi/app.config
+++ b/src/MoBi/app.config
@@ -1,129 +1,13 @@
 <?xml version="1.0" encoding="utf-8"?>
 <configuration>
-   <startup useLegacyV2RuntimeActivationPolicy="true">
-      <supportedRuntime version="v4.0" sku=".NETFramework,Version=v4.6.2" />
-   </startup>
+  <startup useLegacyV2RuntimeActivationPolicy="true">
+    <supportedRuntime version="v4.0" sku=".NETFramework,Version=v4.7.2" />
+  </startup>
   <runtime>
     <assemblyBinding xmlns="urn:schemas-microsoft-com:asm.v1">
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.Utils.v18.2" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.Data.v18.2" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="System.Windows.Forms" publicKeyToken="b77a5c561934e089" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-4.0.0.0" newVersion="4.0.0.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.XtraTreeList.v18.2" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.XtraEditors.v18.2" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.XtraGrid.v18.2" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.XtraBars.v18.2" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.XtraCharts.v18.2.UI" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.XtraCharts.v18.2" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.XtraPivotGrid.v18.2" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.PivotGrid.v18.2.Core" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.RichEdit.v18.2.Core" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.XtraRichEdit.v18.2" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.XtraRichEdit.v18.2.Extensions" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.Charts.v18.2.Core" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.Office.v18.2.Core" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.BonusSkins.v18.2" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.XtraLayout.v18.2" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="MPFitLib" publicKeyToken="be1b3c0b5819660a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-1.0.0.0" newVersion="1.0.0.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="ICSharpCode.SharpZipLib" publicKeyToken="1b03e6acf1164f73" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-0.86.0.518" newVersion="0.86.0.518" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="System.Data.SQLite" publicKeyToken="db937bc2d44ff139" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-1.0.110.0" newVersion="1.0.110.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="Northwoods.Go" publicKeyToken="a4e3b7b70161cfe8" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-4.1.0.2" newVersion="4.1.0.2" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="Northwoods.Go.Xml" publicKeyToken="a4e3b7b70161cfe8" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-5.2.0.45" newVersion="5.2.0.45" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="Northwoods.Go.Layout" publicKeyToken="a4e3b7b70161cfe8" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-4.1.0.2" newVersion="4.1.0.2" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="NHibernate" publicKeyToken="aa95f207798dfdb4" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-5.2.0.0" newVersion="5.2.0.0" />
-      </dependentAssembly>
       <dependentAssembly>
         <assemblyIdentity name="SX" publicKeyToken="882b9c044052e7f6" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-2.7.0.9" newVersion="2.7.0.9" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.Printing.v18.2.Core" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="Iesi.Collections" publicKeyToken="aa95f207798dfdb4" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-4.0.0.4000" newVersion="4.0.0.4000" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="Newtonsoft.Json" publicKeyToken="30ad4fe6b2a6aeed" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-10.0.0.0" newVersion="10.0.0.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="Microsoft.Extensions.Logging.Abstractions" publicKeyToken="adb9793829ddae60" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-2.1.1.0" newVersion="2.1.1.0" />
+        <bindingRedirect oldVersion="0.0.0.0-2.7.4.7" newVersion="2.7.4.7" />
       </dependentAssembly>
     </assemblyBinding>
   </runtime>
diff --git a/src/MoBi/packages.config b/src/MoBi/packages.config
deleted file mode 100644
index f93e43fa0..000000000
--- a/src/MoBi/packages.config
+++ /dev/null
@@ -1,21 +0,0 @@
-<?xml version="1.0" encoding="utf-8"?>
-<packages>
-  <package id="csmpfit" version="1.1.1" targetFramework="net462" />
-  <package id="MathNet.Numerics" version="4.7.0" targetFramework="net462" />
-  <package id="Microsoft.Extensions.Logging.Abstractions" version="2.2.0" targetFramework="net462" />
-  <package id="OSPSuite.Assets" version="8.0.4" targetFramework="net462" />
-  <package id="OSPSuite.Core" version="8.0.4" targetFramework="net462" />
-  <package id="OSPSuite.DevExpress.Presentation" version="18.2.7" targetFramework="net462" />
-  <package id="OSPSuite.Engine" version="8.0.4" targetFramework="net462" />
-  <package id="OSPSuite.FuncParser" version="3.0.1.14" targetFramework="net462" />
-  <package id="OSPSuite.Presentation" version="8.0.4" targetFramework="net462" />
-  <package id="OSPSuite.Serializer" version="2.0.1.4" targetFramework="net462" />
-  <package id="OSPSuite.SimModel" version="3.0.1.27" targetFramework="net462" />
-  <package id="OSPSuite.SimModelSolver_CVODES" version="4.0.0.5" />
-  <package id="OSPSuite.SmartXLS" version="2.7.0.9" targetFramework="net462" />
-  <package id="OSPSuite.TeXReporting" version="2.1.1.9" targetFramework="net462" />
-  <package id="OSPSuite.Utility" version="3.0.1.7" targetFramework="net462" />
-  <package id="System.ValueTuple" version="4.4.0" targetFramework="net462" />
-  <package id="WindowsAPICodePack-Core" version="1.1.2" targetFramework="net462" />
-  <package id="WindowsAPICodePack-Shell" version="1.1.1" targetFramework="net462" />
-</packages>
\ No newline at end of file
diff --git a/tests/MoBi.Tests/ContextSpecification.cs b/tests/MoBi.Tests/ContextSpecification.cs
deleted file mode 100644
index 1e80c7596..000000000
--- a/tests/MoBi.Tests/ContextSpecification.cs
+++ /dev/null
@@ -1,24 +0,0 @@
-using System.Threading.Tasks;
-using OSPSuite.BDDHelper;
-using OSPSuite.Engine;
-
-namespace MoBi
-{
-   public abstract class ContextSpecificationAsync<T> : AbstractContextSpecificationAsync<T>
-   {
-      public override async Task GlobalContext()
-      {
-         await base.GlobalContext();
-         EngineRegister.InitFormulaParser();
-      }
-   }
-
-   public abstract class ContextSpecification<T> : AbstractContextSpecification<T>
-   {
-      public override void GlobalContext()
-      {
-         base.GlobalContext();
-         EngineRegister.InitFormulaParser();
-      }
-   }
-}
\ No newline at end of file
diff --git a/tests/MoBi.Tests/Core/Commands/RemoveSimulationCommandSpecs.cs b/tests/MoBi.Tests/Core/Commands/RemoveSimulationCommandSpecs.cs
index eca082474..2168e7991 100644
--- a/tests/MoBi.Tests/Core/Commands/RemoveSimulationCommandSpecs.cs
+++ b/tests/MoBi.Tests/Core/Commands/RemoveSimulationCommandSpecs.cs
@@ -18,7 +18,7 @@ public abstract class concern_for_RemoveSimulationCommand : ContextWithLoadedPro
       protected override void Context()
       {
          base.Context();
-         var simulationTransfer = LoadPKML<SimulationTransfer>("523_Export_S1");
+         var simulationTransfer = LoadPKML<SimulationTransfer>("Sim");
          _context = IoC.Resolve<IMoBiContext>();
          _simulation = simulationTransfer.Simulation as IMoBiSimulation;
          _context.Register(_simulation);
diff --git a/tests/MoBi.Tests/Core/Commands/SetParameterDimensionInBuildingBlockCommandSpecs.cs b/tests/MoBi.Tests/Core/Commands/SetParameterDimensionInBuildingBlockCommandSpecs.cs
index 386ee1997..59071f7c7 100644
--- a/tests/MoBi.Tests/Core/Commands/SetParameterDimensionInBuildingBlockCommandSpecs.cs
+++ b/tests/MoBi.Tests/Core/Commands/SetParameterDimensionInBuildingBlockCommandSpecs.cs
@@ -2,7 +2,6 @@
 using OSPSuite.BDDHelper;
 using OSPSuite.BDDHelper.Extensions;
 using MoBi.Core.Domain.Model;
-using MoBi.Core.Services;
 using OSPSuite.Core.Domain;
 using OSPSuite.Core.Domain.Builder;
 using OSPSuite.Core.Domain.Formulas;
@@ -58,6 +57,7 @@ public void dimension_of_parameter_changes()
       {
          _parameter.Dimension.ShouldBeEqualTo(_newDimension);
       }
+
    }
 
    public class When_setting_new_dimension_for_parameter_with_right_hand_side : concern_for_SetParameterDimensionInBuildingBlockCommand
@@ -71,7 +71,7 @@ protected override void Context()
          _newRightHandSideDimension = A.Fake<IDimension>();
          _newDisplayUnit = A.Fake<Unit>();
          _parameter.RHSFormula= A.Fake<IFormula>();
-         A.CallTo(() => _context.DimensionFactory.RHSDimensionFor(_newDimension)).Returns(_newRightHandSideDimension);
+         A.CallTo(() => _context.DimensionFactory.GetOrAddRHSDimensionFor(_newDimension)).Returns(_newRightHandSideDimension);
          var displayUnitRetriever = A.Fake<IDisplayUnitRetriever>();
          A.CallTo(() => _context.Resolve<IDisplayUnitRetriever>()).Returns(displayUnitRetriever);
          A.CallTo(displayUnitRetriever).WithReturnType<Unit>().Returns(_newDisplayUnit);
@@ -117,7 +117,7 @@ protected override void Context()
          base.Context();
          _newRightHandSideDimension = A.Fake<IDimension>();
          _newDisplayUnit = A.Fake<Unit>();
-         A.CallTo(() => _context.DimensionFactory.RHSDimensionFor(_newDimension)).Returns(_newRightHandSideDimension);
+         A.CallTo(() => _context.DimensionFactory.GetOrAddRHSDimensionFor(_newDimension)).Returns(_newRightHandSideDimension);
          var displayUnitRetriever = A.Fake<IDisplayUnitRetriever>();
          A.CallTo(() => _context.Resolve<IDisplayUnitRetriever>()).Returns(displayUnitRetriever);
          A.CallTo(displayUnitRetriever).WithReturnType<Unit>().Returns(_newDisplayUnit);
diff --git a/tests/MoBi.Tests/Core/Converter313To32Specs.cs b/tests/MoBi.Tests/Core/Converter313To32Specs.cs
deleted file mode 100644
index 0871f8bad..000000000
--- a/tests/MoBi.Tests/Core/Converter313To32Specs.cs
+++ /dev/null
@@ -1,111 +0,0 @@
-using System.Linq;
-using System.Xml.Linq;
-using OSPSuite.BDDHelper;
-using OSPSuite.BDDHelper.Extensions;
-using OSPSuite.Utility.Events;
-using FakeItEasy;
-using MoBi.Core.Domain.Model;
-using MoBi.Core.Domain.UnitSystem;
-using MoBi.Core.Serialization.Converter.v3_2;
-using OSPSuite.Core.Converter.v5_2;
-using OSPSuite.Core.Domain;
-using OSPSuite.Core.Domain.Data;
-
-namespace MoBi.Core
-{
-   public abstract class concern_for_Converter313To32 : ContextSpecification<Converter313To32>
-   {
-      protected IDimensionConverter _dimensionConverter;
-      private IMoBiDimensionFactory _dimensionFactory;
-      private IObjectBaseFactory _objectBaseFactory;
-      private IFormulaMapper _formulaMapper;
-      private IDimensionMapper _dimensionMapper;
-      private IEventPublisher _eventPublisher;
-
-      protected override void Context()
-      {
-         _dimensionConverter = A.Fake<IDimensionConverter>();
-         _dimensionFactory = A.Fake<IMoBiDimensionFactory>();
-         _objectBaseFactory = A.Fake<IObjectBaseFactory>();
-         _formulaMapper = A.Fake<IFormulaMapper>();
-         _dimensionMapper = A.Fake<IDimensionMapper>();
-         _eventPublisher = A.Fake<IEventPublisher>();
-         sut = new Converter313To32(_dimensionConverter, _dimensionFactory, _objectBaseFactory, _formulaMapper, _dimensionMapper, _eventPublisher);
-      }
-   }
-
-   class When_converting_an_mobi_project : concern_for_Converter313To32
-   {
-      private IMoBiProject _mobiProject;
-      private DataRepository _observedData;
-
-      protected override void Context()
-      {
-         base.Context();
-         _mobiProject = new MoBiProject();
-         _observedData = new DataRepository();
-         _mobiProject.AddObservedData(_observedData);
-      }
-
-      protected override void Because()
-      {
-         sut.Convert(_mobiProject, null);
-      }
-
-      [Observation]
-      public void should_call_dimension_converter_for_data_repositories()
-      {
-         A.CallTo(() => _dimensionConverter.ConvertDimensionIn(_observedData)).MustHaveHappened();
-      }
-   }
-
-   public class When_converting_an_old_dimension_xml_files : concern_for_Converter313To32
-   {
-      private XElement _element;
-
-      protected override void Context()
-      {
-         base.Context();
-         _element = new XElement("DimensionFactory",
-                                 new XElement("Dimensions",
-                                              new XElement("Dimension", new XAttribute("name", "dim1"), new XAttribute("BaseUnit", "unit1"), new XAttribute("DefaultUnit", "unit2")),
-                                              new XElement("Dimension", new XAttribute("name", "dim2"), new XAttribute("BaseUnit", "unit1"), new XAttribute("DefaultUnit", "unit2")),
-                                              new XElement("Dimension", new XAttribute("name", "dim3"), new XAttribute("BaseUnit", "unit1"))
-                                    )
-            );
-      }
-
-      protected override void Because()
-      {
-         sut.ConvertXml(_element, null);
-      }
-
-      [Observation]
-      public void should_have_replaced_the_attributes_to_lower_case_values()
-      {
-         var allBaseUnits = _element.DescendantsAndSelf().Where(x => x.Attribute("baseUnit") != null);
-         allBaseUnits.Count().ShouldBeEqualTo(3);
-
-         var allDefaultUnits = _element.DescendantsAndSelf().Where(x => x.Attribute("defaultUnit") != null);
-         allDefaultUnits.Count().ShouldBeEqualTo(2);
-      }
-   }
-
-   public class When_converting_an_observed_building_block_element_without_builder : concern_for_Converter313To32
-   {
-      private XElement _element;
-
-      protected override void Context()
-      {
-         base.Context();
-         base.Context();
-         _element = new XElement("ObserverBuildingBlock");
-      }
-
-      [Observation]
-      public void should_not_crash()
-      {
-         sut.ConvertXml(_element, null);
-      }
-   }
-}
\ No newline at end of file
diff --git a/tests/MoBi.Tests/Core/DimensionConverterSpecs.cs b/tests/MoBi.Tests/Core/DimensionConverterSpecs.cs
index 6b8f85bc4..0728ebf43 100644
--- a/tests/MoBi.Tests/Core/DimensionConverterSpecs.cs
+++ b/tests/MoBi.Tests/Core/DimensionConverterSpecs.cs
@@ -9,7 +9,7 @@
 
 namespace MoBi.Core
 {
-   public abstract class concern_for_DimensionCoverterFor<T> : ContextSpecification<DimensionConverterFor<T>> where T : IWithDimension
+   public abstract class concern_for_DimensionConverterFor<T> : ContextSpecification<DimensionConverter<T>> where T : IWithDimension
 
    {
       private IDimension _source;
@@ -22,7 +22,7 @@ protected override void Context()
          sut = new TestDimensionConverterFor(_source, _target);
       }
 
-      public class TestDimensionConverterFor : DimensionConverterFor<T>
+      public class TestDimensionConverterFor : DimensionConverter<T>
       {
          public TestDimensionConverterFor(IDimension sourceDimension, IDimension targetDimension) : base(sourceDimension, targetDimension)
          {
@@ -45,7 +45,7 @@ public override string UnableToResolveParametersMessage
    }
 
 
-   public class When_a_parameter_converter_is_asked_to_convert_a_Parameter : concern_for_DimensionCoverterFor<IParameter>
+   public class When_a_parameter_converter_is_asked_to_convert_a_Parameter : concern_for_DimensionConverterFor<IParameter>
    {
       private bool _res;
 
@@ -62,7 +62,7 @@ public void should_return_true()
       }
    }
 
-   public class When_a_parameter_converter_is_asked_to_convert_a_DataColumn : concern_for_DimensionCoverterFor<IParameter>
+   public class When_a_parameter_converter_is_asked_to_convert_a_DataColumn : concern_for_DimensionConverterFor<IParameter>
    {
       private bool _res;
 
diff --git a/tests/MoBi.Tests/Core/DimensionValidatorSpecs.cs b/tests/MoBi.Tests/Core/DimensionValidatorSpecs.cs
index 3c0c6ade8..0fcb98da3 100644
--- a/tests/MoBi.Tests/Core/DimensionValidatorSpecs.cs
+++ b/tests/MoBi.Tests/Core/DimensionValidatorSpecs.cs
@@ -3,7 +3,7 @@
 using FakeItEasy;
 using MoBi.Assets;
 using MoBi.Core.Domain.Services;
-using MoBi.Engine.Tasks;
+using MoBi.Core.Services;
 using MoBi.Presentation.Settings;
 using MoBi.Presentation.Tasks;
 using OSPSuite.BDDHelper;
@@ -20,7 +20,7 @@ namespace MoBi.Core
    public abstract class concern_for_DimensionValidator : ContextSpecification<IDimensionValidator>
    {
       protected ObjectPathFactory _pathFactory;
-      private IUserSettings _userSettings;
+      protected IUserSettings _userSettings;
       protected IBuildConfiguration _buildConfiguration;
 
       protected override void Context()
@@ -294,7 +294,7 @@ protected override void Because()
       }
 
       [Observation]
-      public void should_return_valide_with_warnings()
+      public void should_return_valid_with_warnings()
       {
          _result.ValidationState.ShouldBeEqualTo(ValidationState.ValidWithWarnings);
       }
@@ -306,7 +306,7 @@ public void should_have_the_right_messages()
       }
    }
 
-   public class When_validating_a_Formula_using_object_dimension_and_formula_with_missmatching_dimensions : concern_for_DimensionValidator
+   public class When_validating_a_Formula_using_object_dimension_and_formula_with_miss_matching_dimensions : concern_for_DimensionValidator
    {
       private IContainer _root;
       private IParameter _para;
@@ -333,6 +333,8 @@ protected override void Context()
          _para.Formula.AddObjectPath(_pathFactory.CreateRelativeFormulaUsablePath(_para, a));
          _para.Formula.AddObjectPath(_pathFactory.CreateRelativeFormulaUsablePath(_para, b));
          _para.Formula.ResolveObjectPathsFor(_para);
+
+         _userSettings.ShowCannotCalcErrors = true;
       }
 
       protected override void Because()
@@ -349,7 +351,7 @@ public void should_return_invalid()
       [Observation]
       public void should_have_the_correct_messages()
       {
-         _result.Messages.Single().Text.ShouldBeEqualTo(String.Format("Arguments of PLUS-function must have the same dimension (Formula: {0})", _formulaString));
+         _result.Messages.Single().Text.ShouldBeEqualTo($"Arguments of PLUS-function must have the same dimension (Formula: {_formulaString})");
       }
    }
 
diff --git a/tests/MoBi.Tests/Core/FormulaCachePresenterSpecs.cs b/tests/MoBi.Tests/Core/FormulaCachePresenterSpecs.cs
index cdecdeaba..f89d2a1e9 100644
--- a/tests/MoBi.Tests/Core/FormulaCachePresenterSpecs.cs
+++ b/tests/MoBi.Tests/Core/FormulaCachePresenterSpecs.cs
@@ -62,7 +62,7 @@ protected override void Context()
          _dtoFormula = new FormulaBuilderDTO();
          _dtoFormula.Id = _formula.Id;
          A.CallTo(() => _formulaChecker.FormulaUsedIn(_buildingBlock,_formula)).Returns(false);
-         A.CallTo(() => _messagePresenter.MessageBoxYesNo(AppConstants.Captions.ReallyDeleteFormula(_formula.Name)))
+         A.CallTo(() => _messagePresenter.MessageBoxYesNo(AppConstants.Captions.ReallyDeleteFormula(_formula.Name), ViewResult.Yes))
           .Returns(ViewResult.Yes);
          
       }
diff --git a/tests/MoBi.Tests/Core/Mapper/ParameterToDTOParameterMapperSpecs.cs b/tests/MoBi.Tests/Core/Mapper/ParameterToDTOParameterMapperSpecs.cs
index d5302c9fd..c48fe5f60 100644
--- a/tests/MoBi.Tests/Core/Mapper/ParameterToDTOParameterMapperSpecs.cs
+++ b/tests/MoBi.Tests/Core/Mapper/ParameterToDTOParameterMapperSpecs.cs
@@ -9,6 +9,7 @@
 using FakeItEasy;
 using OSPSuite.BDDHelper;
 using OSPSuite.BDDHelper.Extensions;
+using OSPSuite.Core.Domain.Mappers;
 using OSPSuite.Presentation.DTO;
 using OSPSuite.Presentation.Mappers;
 using OSPSuite.Utility.Extensions;
@@ -19,7 +20,7 @@ namespace MoBi.Core.Mapper
    public abstract class concern_for_ParameterToDTOParameterMapper : ContextSpecification<IParameterToParameterDTOMapper>
    {
       protected IFormulaToFormulaBuilderDTOMapper _formulaMapper;
-      protected ITagToTagDTOMapper _tagMappper;
+      protected ITagToTagDTOMapper _tagMapper;
       protected IGroupRepository _groupRepository;
       protected IFavoriteRepository _favoriteRepository;
       protected IEntityPathResolver _entityPathResolver;
@@ -28,12 +29,12 @@ public abstract class concern_for_ParameterToDTOParameterMapper : ContextSpecifi
       protected override void Context()
       {
          _formulaMapper = A.Fake<IFormulaToFormulaBuilderDTOMapper>();
-         _tagMappper = A.Fake<ITagToTagDTOMapper>();
+         _tagMapper = A.Fake<ITagToTagDTOMapper>();
          _groupRepository= A.Fake<IGroupRepository>();
          _favoriteRepository = A.Fake<IFavoriteRepository>();
          _entityPathResolver = A.Fake<IEntityPathResolver>();
          _pathToPathElementsMapper= A.Fake<IPathToPathElementsMapper>();
-         sut = new ParameterToParameterDTOMapper(_formulaMapper,_tagMappper,_groupRepository,_favoriteRepository,_entityPathResolver, _pathToPathElementsMapper);
+         sut = new ParameterToParameterDTOMapper(_formulaMapper,_tagMapper,_groupRepository,_favoriteRepository,_entityPathResolver, _pathToPathElementsMapper);
       }
    }
 
@@ -89,8 +90,8 @@ public void should_ask_to_map_formulas()
       [Observation]
       public void should_ask_map_all_tags()
       {
-         A.CallTo(() => _tagMappper.MapFrom(_tag)).MustHaveHappened();
-         A.CallTo(() => _tagMappper.MapFrom(_otherTag)).MustHaveHappened();
+         A.CallTo(() => _tagMapper.MapFrom(_tag)).MustHaveHappened();
+         A.CallTo(() => _tagMapper.MapFrom(_otherTag)).MustHaveHappened();
       }
 
       [Observation]
@@ -157,8 +158,8 @@ public void should_ask_to_map_formulas()
       [Observation]
       public void should_ask_map_all_Tags()
       {
-         A.CallTo(() => _tagMappper.MapFrom(_tag)).MustHaveHappened();
-         A.CallTo(() => _tagMappper.MapFrom(_otherTag)).MustHaveHappened();
+         A.CallTo(() => _tagMapper.MapFrom(_tag)).MustHaveHappened();
+         A.CallTo(() => _tagMapper.MapFrom(_otherTag)).MustHaveHappened();
       }
 
       [Observation]
@@ -221,8 +222,8 @@ public void should_ask_to_map_formulas()
       [Observation]
       public void should_ask_map_all_Tags()
       {
-         A.CallTo(() => _tagMappper.MapFrom(_tag)).MustHaveHappened();
-         A.CallTo(() => _tagMappper.MapFrom(_otherTag)).MustHaveHappened();
+         A.CallTo(() => _tagMapper.MapFrom(_tag)).MustHaveHappened();
+         A.CallTo(() => _tagMapper.MapFrom(_otherTag)).MustHaveHappened();
       }
 
       [Observation]
diff --git a/tests/MoBi.Tests/Core/MoBiContextSpecs.cs b/tests/MoBi.Tests/Core/MoBiContextSpecs.cs
index 25d751b6e..6d60e0245 100644
--- a/tests/MoBi.Tests/Core/MoBiContextSpecs.cs
+++ b/tests/MoBi.Tests/Core/MoBiContextSpecs.cs
@@ -11,7 +11,7 @@
 using OSPSuite.Core.Domain.Formulas;
 using OSPSuite.Core.Domain.Services;
 using OSPSuite.Core.Domain.UnitSystem;
-using OSPSuite.Infrastructure.Journal;
+using OSPSuite.Infrastructure.Serialization.Journal;
 using OSPSuite.Infrastructure.Serialization.ORM.History;
 using OSPSuite.Utility.Events;
 using OSPSuite.Utility.FileLocker;
@@ -27,7 +27,7 @@ public abstract class concern_for_MoBiContext : ContextSpecification<IMoBiContex
       private IXmlSerializationService _serializationService;
       private IObjectPathFactory _objectPathFactory;
       protected IWithIdRepository _objectBaseRepository;
-      private IHistoryManagerFactory _moBiHistoryManagerFacory;
+      private IHistoryManagerFactory _moBiHistoryManagerFactory;
       private IRegisterTask _registerTask;
       protected IUnregisterTask _unregisterTask;
       private IClipboardManager _clipboardManager;
@@ -45,7 +45,7 @@ protected override void Context()
          _objectBaseFactory = A.Fake<IObjectBaseFactory>();
          _registerTask = A.Fake<IRegisterTask>();
          _objectBaseRepository = A.Fake<IWithIdRepository>();
-         _moBiHistoryManagerFacory = A.Fake<IHistoryManagerFactory>();
+         _moBiHistoryManagerFactory = A.Fake<IHistoryManagerFactory>();
          _serializationService = A.Fake<IXmlSerializationService>();
          _objectPathFactory = A.Fake<IObjectPathFactory>();
          _unregisterTask = A.Fake<IUnregisterTask>();
@@ -59,12 +59,12 @@ protected override void Context()
 
          sut = new MoBiContext(_objectBaseFactory, _dimensionFactory, _eventPublisher,
             _serializationService, _objectPathFactory, _objectBaseRepository,
-            _moBiHistoryManagerFacory, _registerTask, _unregisterTask,
+            _moBiHistoryManagerFactory, _registerTask, _unregisterTask,
             _clipboardManager, _container,
             _objectTypeResolver, _cloneManager,
             _journalSession, _fileLocker, _lazyLoadTask);
 
-         A.CallTo(() => _moBiHistoryManagerFacory.Create()).Returns(A.Fake<MoBiHistoryManager>());
+         A.CallTo(() => _moBiHistoryManagerFactory.Create()).Returns(A.Fake<MoBiHistoryManager>());
       }
    }
 
@@ -76,7 +76,6 @@ protected override void Context()
       {
          base.Context();
          _project = A.Fake<IMoBiProject>();
-         _project.DimensionFactory = A.Fake<IDimensionFactory>();
          _project.Name = "Neu";
          sut.LoadFrom(_project);
       }
@@ -91,7 +90,6 @@ public void should_set_the_reference_to_current_project_and_history_manager_to_n
       {
          sut.CurrentProject.ShouldBeNull();
          sut.HistoryManager.ShouldBeNull();
-         sut.DimensionFactory.ProjectFactory.ShouldBeNull();
       }
 
       [Observation]
@@ -109,7 +107,6 @@ protected override void Context()
       {
          base.Context();
          var project = A.Fake<IMoBiProject>();
-         project.DimensionFactory = A.Fake<IDimensionFactory>();
          project.Name = "Neu";
          A.CallTo(() => _objectBaseFactory.Create<IMoBiProject>()).Returns(project);
          sut.NewProject();
@@ -136,7 +133,6 @@ protected override void Context()
       {
          base.Context();
          _project = A.Fake<IMoBiProject>();
-         _project.DimensionFactory = A.Fake<IDimensionFactory>();
          _project.Name = "Neu";
          sut.LoadFrom(_project);
          _newObjectBase = A.Fake<IObjectBase>();
@@ -171,7 +167,6 @@ protected override void Context()
       {
          base.Context();
          _project = A.Fake<IMoBiProject>();
-         _project.DimensionFactory = A.Fake<IDimensionFactory>();
          _project.Name = "Neu";
          _newObjectBase = A.Fake<IObjectBase>();
          id = "ID";
@@ -206,7 +201,6 @@ protected override void Context()
       {
          base.Context();
          _newProject = A.Fake<IMoBiProject>();
-         _newProject.DimensionFactory = A.Fake<IDimensionFactory>();
          _newProject.Name = "Neu";
          A.CallTo(() => _objectBaseFactory.Create<IMoBiProject>()).Returns(_newProject);
       }
@@ -221,12 +215,6 @@ public void should_set_current_project_to_the_new_project()
       {
          sut.CurrentProject.ShouldBeEqualTo(_newProject);
       }
-
-      [Observation]
-      public void should_set_the_Project_dimension_factory_to_the_project_ones()
-      {
-         sut.DimensionFactory.ProjectFactory.ShouldBeEqualTo(_newProject.DimensionFactory);
-      }
    }
 
    public class When_unregistering_a_simulation_from_context : concern_for_MoBiContext
diff --git a/tests/MoBi.Tests/Core/MoBiDimensionFactorySpecs.cs b/tests/MoBi.Tests/Core/MoBiDimensionFactorySpecs.cs
index 5c9ab35a5..c43cc218a 100644
--- a/tests/MoBi.Tests/Core/MoBiDimensionFactorySpecs.cs
+++ b/tests/MoBi.Tests/Core/MoBiDimensionFactorySpecs.cs
@@ -1,5 +1,4 @@
 using System.Collections.Generic;
-using MoBi.Assets;
 using MoBi.Core.Domain.UnitSystem;
 using OSPSuite.BDDHelper;
 using OSPSuite.BDDHelper.Extensions;
@@ -15,6 +14,7 @@ public abstract class concern_for_MoBiDimensionFactory : ContextSpecification<IM
       protected Dimension _flowDimension;
       protected Dimension _timeDimension;
       protected Dimension _inversedTimeDimension;
+      private Dimension _anotherDimensionThatLooksLikeVolumeWithADifferentUnit;
 
       protected override void Context()
       {
@@ -22,13 +22,15 @@ protected override void Context()
 
          _drugMassDimension = new Dimension(new BaseDimensionRepresentation(), "DrugMass", "g");
          _volumeDimension = new Dimension(new BaseDimensionRepresentation {MassExponent = 3}, "Volume", "l");
+         _anotherDimensionThatLooksLikeVolumeWithADifferentUnit = new Dimension(new BaseDimensionRepresentation {MassExponent = 3, TimeExponent = -1}, "01_OTHER", "");
          _flowDimension = new Dimension(new BaseDimensionRepresentation {MassExponent = 3, TimeExponent = -1}, "flow", "l/min");
-         _timeDimension = new Dimension(new BaseDimensionRepresentation { TimeExponent = 1}, "Time", "min");
-         _inversedTimeDimension = new Dimension(new BaseDimensionRepresentation{ TimeExponent = -1}, "InversedTime", "1/min");
+         _timeDimension = new Dimension(new BaseDimensionRepresentation {TimeExponent = 1}, "Time", "min");
+         _inversedTimeDimension = new Dimension(new BaseDimensionRepresentation {TimeExponent = -1}, "InversedTime", "1/min");
 
          sut.AddDimension(_drugMassDimension);
          sut.AddDimension(_volumeDimension);
          sut.AddDimension(_flowDimension);
+         sut.AddDimension(_anotherDimensionThatLooksLikeVolumeWithADifferentUnit);
          sut.AddDimension(_timeDimension);
          sut.AddDimension(_inversedTimeDimension);
          sut.AddDimension(Constants.Dimension.NO_DIMENSION);
@@ -90,52 +92,4 @@ public void should_throw_an_exception()
          The.Action(() => sut.Dimension("TRALALA")).ShouldThrowAn<KeyNotFoundException>();
       }
    }
-
-   public class When_told_to_retrieve_a_dimension_by_name_that_does_not_exist_and_but_that_is_an_RHS_dimension : concern_for_MoBiDimensionFactory
-   {
-      [Observation]
-      public void should_return_a_new_dimension()
-      {
-         sut.Dimension(AppConstants.RHSDimensionName(_drugMassDimension)).ShouldNotBeNull();
-      }
-   }
-
-
-   public class When_told_to_retrieve_the_RHS_dimension_for_the_dimensionless_dimension : concern_for_MoBiDimensionFactory
-   {
-      [Observation]
-      public void should_return_the_per_time_dimension()
-      {
-         var rhsDimension = sut.RHSDimensionFor(Constants.Dimension.NO_DIMENSION);
-         rhsDimension.ShouldBeEqualTo(_inversedTimeDimension);
-      }
-   }
-
-   public class When_told_to_retrieve_the_RHS_dimension_for_the_time_dimension : concern_for_MoBiDimensionFactory
-   {
-      [Observation]
-      public void should_return_the_fraction_dimension()
-      {
-         var rhsDimension = sut.RHSDimensionFor(_timeDimension);
-         rhsDimension.ShouldBeEqualTo(Constants.Dimension.NO_DIMENSION);
-      }
-   }
-
-   public class When_told_to_retrieve_a_rhs_dimension_for_a_dimension : concern_for_MoBiDimensionFactory
-   {
-      [Observation]
-      public void should_return_the_equivalent_dimension_if_it_exists_instead_of_creating_a_new_one()
-      {
-         sut.RHSDimensionFor(_volumeDimension).ShouldBeEqualTo(_flowDimension);
-      }
-   }
-
-   public class When_told_to_retrieve_a_dimension_by_name_that_does_not_exist_and_that_is_not_a_possible_RHS_dimension : concern_for_MoBiDimensionFactory
-   {
-      [Observation]
-      public void should_return_a_new_dimension()
-      {
-         The.Action(() => sut.Dimension("TRALALAL" + AppConstants.RHSDimensionSuffix)).ShouldThrowAn<KeyNotFoundException>();
-      }
-   }
 }
\ No newline at end of file
diff --git a/tests/MoBi.Tests/Core/MoBiMergedDimensionFactorySpecs.cs b/tests/MoBi.Tests/Core/MoBiMergedDimensionFactorySpecs.cs
index 52ff9ad61..21a9a876a 100644
--- a/tests/MoBi.Tests/Core/MoBiMergedDimensionFactorySpecs.cs
+++ b/tests/MoBi.Tests/Core/MoBiMergedDimensionFactorySpecs.cs
@@ -8,9 +8,9 @@
 
 namespace MoBi.Core
 {
-   public abstract class concern_for_MoBiMergedDimensionFactory : ContextSpecification<MoBiMergedDimensionFactory>
+   public abstract class concern_for_MoBiMergedDimensionFactory : ContextSpecification<MoBiDimensionFactory>
    {
-      protected IMoBiDimensionConverterFor<IParameter> _converter;
+      protected IMoBiDimensionConverter<IParameter> _converter;
       protected IDimension _source;
       protected IDimension _target;
 
@@ -24,7 +24,7 @@ protected override void Context()
          _target.DefaultUnit = _target.Unit("mmol");
          _converter = new TestDimensionConverterFor<IParameter>(_source, _target);
 
-         sut = new MoBiMergedDimensionFactory();
+         sut = new MoBiDimensionFactory();
       }
 
     
@@ -92,7 +92,7 @@ public void should_return_the_dimension_of_the_column()
 
    public class When_two_posssible_converter_for_One_conversion_are_present : concern_for_MoBiMergedDimensionFactory
    {
-      private IMoBiDimensionConverterFor<DataColumn> _otherConverter;
+      private IMoBiDimensionConverter<DataColumn> _otherConverter;
       private IParameter _parameter;
       private MergedDimensionFor<IParameter> _res;
 
@@ -132,7 +132,7 @@ public void Shoul_return_a_new_merged_dimnsion()
       }
    }
 
-   internal class TestDimensionConverterFor<T> : DimensionConverterFor<T> where T : IWithDimension
+   internal class TestDimensionConverterFor<T> : DimensionConverter<T> where T : IWithDimension
    {
       public TestDimensionConverterFor(IDimension sourceDimension, IDimension targetDimension)
          : base(sourceDimension, targetDimension)
diff --git a/tests/MoBi.Tests/Core/SBML/Helper.cs b/tests/MoBi.Tests/Core/SBML/Helper.cs
index c58451165..550dd6c03 100644
--- a/tests/MoBi.Tests/Core/SBML/Helper.cs
+++ b/tests/MoBi.Tests/Core/SBML/Helper.cs
@@ -3,12 +3,12 @@
 
 namespace MoBi.Core.SBML
 {
-    public class Helper
-    {
-        public static string TestFileFullPath(string fileName)
-        {
-            var dataFolder = Path.Combine(Path.Combine(Path.Combine(Path.Combine(AppDomain.CurrentDomain.BaseDirectory, "..\\.."),"Core","SBML", "Testfiles")));
-            return Path.Combine(dataFolder, fileName);
-        }
-    }
+   public class Helper
+   {
+      public static string TestFileFullPath(string fileName)
+      {
+         var dataFolder = Path.Combine(AppDomain.CurrentDomain.BaseDirectory, "..", "..", "..", "Core", "SBML", "Testfiles");
+         return Path.Combine(dataFolder, fileName);
+      }
+   }
 }
\ No newline at end of file
diff --git a/tests/MoBi.Tests/Core/SerializationContextFactorySpecs.cs b/tests/MoBi.Tests/Core/SerializationContextFactorySpecs.cs
deleted file mode 100644
index 3dbde7f5d..000000000
--- a/tests/MoBi.Tests/Core/SerializationContextFactorySpecs.cs
+++ /dev/null
@@ -1,131 +0,0 @@
-using FakeItEasy;
-using MoBi.Core.Domain.Model;
-using MoBi.Core.Serialization.Services;
-using MoBi.Core.Services;
-using OSPSuite.BDDHelper;
-using OSPSuite.BDDHelper.Extensions;
-using OSPSuite.Core.Converter.v5_2;
-using OSPSuite.Core.Domain;
-using OSPSuite.Core.Domain.Data;
-using OSPSuite.Core.Domain.Services;
-using OSPSuite.Core.Serialization.Xml;
-using IContainer = OSPSuite.Utility.Container.IContainer;
-
-namespace MoBi.Core
-{
-   public abstract class concern_for_SerializationContextFactory : ContextSpecification<ISerializationContextFactory>
-   {
-      protected ISerializationDimensionFactory _dimensionFactory;
-      protected IObjectBaseFactory _objectBaseFactory;
-      protected ICloneManagerForModel _cloneManagerForModel;
-      protected IContainer _container;
-      protected IMoBiProjectRetriever _projectRetriever;
-      protected IMoBiProject _project;
-
-      protected override void Context()
-      {
-         _dimensionFactory = A.Fake<ISerializationDimensionFactory>();
-         _objectBaseFactory = A.Fake<IObjectBaseFactory>();
-         _cloneManagerForModel = A.Fake<ICloneManagerForModel>();
-         _container = A.Fake<IContainer>();
-
-         sut = new SerializationContextFactory(_dimensionFactory, _objectBaseFactory, _cloneManagerForModel, _container);
-
-         _projectRetriever = A.Fake<IMoBiProjectRetriever>();
-
-         A.CallTo(() => _container.Resolve<IMoBiProjectRetriever>()).Returns(_projectRetriever);
-
-         _project = new MoBiProject();
-         A.CallTo(() => _projectRetriever.Current).Returns(_project);
-      }
-   }
-
-   public class When_creating_a_serialization_context_in_an_empty_project : concern_for_SerializationContextFactory
-   {
-      private SerializationContext _result;
-
-      protected override void Because()
-      {
-         _result = sut.Create();
-      }
-
-      [Observation]
-      public void should_return_a_serialization_context_without_any_data_repositories_or_simulation_registered()
-      {
-         _result.IdRepository.All().ShouldBeEmpty();
-         _result.Repositories.ShouldBeEmpty();
-      }
-   }
-
-   public class When_creating_a_serialization_context_based_on_a_parent_serialization_context : concern_for_SerializationContextFactory
-   {
-      private SerializationContext _result;
-      private SerializationContext _parentContext;
-      private DataRepository _dataRepo1;
-      private IWithId _simmulation;
-
-      protected override void Context()
-      {
-         base.Context();
-         _dataRepo1 = new DataRepository("OBS1");
-         _simmulation = new MoBiSimulation().WithId("ID");
-         _parentContext = new SerializationContext(_dimensionFactory, _objectBaseFactory, new WithIdRepository(), new[] {_dataRepo1}, _cloneManagerForModel, _container);
-         _parentContext.Register(_simmulation);
-      }
-
-      protected override void Because()
-      {
-         _result = sut.Create(_parentContext);
-      }
-
-      [Observation]
-      public void should_add_the_repositories_defined_in_the_parent_context()
-      {
-         _result.Repositories.ShouldContain(_dataRepo1);
-      }
-
-      [Observation]
-      public void should_register_the_object_registered_in_the_parent_context()
-      {
-         _result.IdRepository.All().ShouldContain(_simmulation);
-      }
-   }
-
-   public class When_creating_a_serialization_context_with_a_defined_project : concern_for_SerializationContextFactory
-   {
-      private SerializationContext _result;
-      private DataRepository _observedData;
-      private MoBiSimulation _simmulation;
-      private DataRepository _simulationResults;
-
-      protected override void Context()
-      {
-         base.Context();
-         _observedData = new DataRepository("OBS1");
-         _simulationResults = new DataRepository("RES");
-         _simmulation = new MoBiSimulation().WithId("ID");
-
-         _simmulation.Results = _simulationResults;
-
-         _project.AddSimulation(_simmulation);
-         _project.AddObservedData(_observedData);
-      }
-
-      protected override void Because()
-      {
-         _result = sut.Create();
-      }
-
-      [Observation]
-      public void should_add_the_repositories_defined_in_the_parent_context()
-      {
-         _result.Repositories.ShouldContain(_observedData, _simulationResults);
-      }
-
-      [Observation]
-      public void should_register_the_object_registered_in_the_parent_context()
-      {
-         _result.IdRepository.All().ShouldContain(_simmulation, _observedData, _simulationResults);
-      }
-   }
-}
\ No newline at end of file
diff --git a/tests/MoBi.Tests/Core/Service/AmountToConcentrationConverterSpecs.cs b/tests/MoBi.Tests/Core/Service/AmountToConcentrationConverterSpecs.cs
index 622adfc57..d9438dc88 100644
--- a/tests/MoBi.Tests/Core/Service/AmountToConcentrationConverterSpecs.cs
+++ b/tests/MoBi.Tests/Core/Service/AmountToConcentrationConverterSpecs.cs
@@ -45,7 +45,7 @@ protected override void Context()
          _formulaCache = new FormulaCache();
          _objectTypeResolver=new ObjectTypeResolver();
          A.CallTo(() => _formulaTask.AddParentVolumeReferenceToFormula(A<IFormula>._)).Returns(Constants.VOLUME_ALIAS);
-         A.CallTo(() => _dimensionFactory.Dimension(Constants.Dimension.AMOUNT)).Returns(DomainHelperForSpecs.AmountDimension);
+         A.CallTo(() => _dimensionFactory.Dimension(Constants.Dimension.MOLAR_AMOUNT)).Returns(DomainHelperForSpecs.AmountDimension);
          A.CallTo(() => _dimensionFactory.Dimension(Constants.Dimension.AMOUNT_PER_TIME)).Returns(DomainHelperForSpecs.AmountPerTimeDimension);
          A.CallTo(() => _dimensionFactory.Dimension(Constants.Dimension.MOLAR_CONCENTRATION)).Returns(DomainHelperForSpecs.ConcentrationDimension);
          A.CallTo(() => _dimensionFactory.Dimension(Constants.Dimension.MOLAR_CONCENTRATION_PER_TIME)).Returns(DomainHelperForSpecs.ConcentrationPerTimeDimension);
diff --git a/tests/MoBi.Tests/Core/Service/DataNamingServiceSpecs.cs b/tests/MoBi.Tests/Core/Service/DataNamingServiceSpecs.cs
index e63c42d02..80b3553ac 100644
--- a/tests/MoBi.Tests/Core/Service/DataNamingServiceSpecs.cs
+++ b/tests/MoBi.Tests/Core/Service/DataNamingServiceSpecs.cs
@@ -1,7 +1,6 @@
 using MoBi.Core.Domain.Model;
 using MoBi.Core.Domain.Services;
 using OSPSuite.Core.Domain;
-using OSPSuite.Core.Domain.Services;
 using FakeItEasy;
 using OSPSuite.BDDHelper;
 using OSPSuite.BDDHelper.Extensions;
@@ -9,7 +8,7 @@
 
 namespace MoBi.Core.Service
 {
-   public abstract class concern_for_DataNamingService : ContextSpecification<IDataNamingService>
+   public abstract class concern_for_DataNamingService : ContextSpecification<DataNamingService>
    {
       protected IMoBiContext _context;
 
diff --git a/tests/MoBi.Tests/Core/Service/PassiveTransportConverterSpecs.cs b/tests/MoBi.Tests/Core/Service/PassiveTransportConverterSpecs.cs
deleted file mode 100644
index 6949750b9..000000000
--- a/tests/MoBi.Tests/Core/Service/PassiveTransportConverterSpecs.cs
+++ /dev/null
@@ -1,174 +0,0 @@
-using System;
-using System.Collections.Generic;
-using System.Linq;
-using OSPSuite.BDDHelper;
-using OSPSuite.BDDHelper.Extensions;
-using OSPSuite.Utility.Events;
-using OSPSuite.Utility.Extensions;
-using FakeItEasy;
-using MoBi.Assets;
-using MoBi.Core.Domain.Model;
-using MoBi.Core.Events;
-using MoBi.Core.Services;
-using NUnit.Framework;
-using OSPSuite.Core.Domain;
-using OSPSuite.Core.Domain.Builder;
-using OSPSuite.Core.Domain.Formulas;
-using OSPSuite.Core.Domain.Services;
-
-namespace MoBi.Core.Service
-{
-   public abstract class concern_for_PassiveTransportConverter : ContextSpecification<IPassiveTransportConverter>
-   {
-      protected IContainerTask _containerTask;
-      private IObjectBaseFactory _objectBaseFactory;
-      private IMoBiProjectRetriever _projectRetriever;
-      protected IMoleculeBuilder _moleculeWithPassiveTransport;
-      protected TransportBuilder _passiveTransport;
-      protected IPassiveTransportBuildingBlock _passiveTransports;
-      protected IMoleculeBuildingBlock _molecules;
-      protected IMoBiProject _project;
-      private IEventPublisher _eventPublisher;
-      protected ShowNotificationsEvent _showNotificationEvent;
-      protected ICloneManagerForModel _cloneManagerForModel;
-      protected IFormulaTask _formulaTask;
-      protected IFormula _passiveTransportKinetic;
-
-      protected override void Context()
-      {
-         _containerTask = A.Fake<IContainerTask>();
-         _objectBaseFactory = A.Fake<IObjectBaseFactory>();
-         _projectRetriever = A.Fake<IMoBiProjectRetriever>();
-         _eventPublisher = A.Fake<IEventPublisher>();
-         _cloneManagerForModel = A.Fake<ICloneManagerForModel>();
-         _formulaTask = A.Fake<IFormulaTask>();
-
-         sut = new PassiveTransportConverter(_objectBaseFactory, _projectRetriever, _containerTask, _eventPublisher, _cloneManagerForModel, _formulaTask);
-
-         A.CallTo(() => _containerTask.CreateUniqueName(A<IEnumerable<IWithName>>._, A<string>._, true))
-            .ReturnsLazily(x => x.Arguments[1].ToString());
-
-         _passiveTransportKinetic = new ExplicitFormula("1+2");
-         _moleculeWithPassiveTransport = new MoleculeBuilder().WithName("MOLECULE");
-         _passiveTransport = new TransportBuilder().WithName("PASSIVE TRANSPORT").WithFormula(_passiveTransportKinetic);
-         _moleculeWithPassiveTransport.Add(_passiveTransport);
-         _passiveTransports = new PassiveTransportBuildingBlock();
-         _molecules = new MoleculeBuildingBlock {_moleculeWithPassiveTransport}.WithName("MBB");
-         _project = new MoBiProject();
-         A.CallTo(() => _projectRetriever.Current).Returns(_project);
-         A.CallTo(() => _eventPublisher.PublishEvent(A<ShowNotificationsEvent>._))
-            .Invokes(x => _showNotificationEvent = x.GetArgument<ShowNotificationsEvent>(0));
-      }
-   }
-
-   public class When_converting_a_simulation_using_passive_transports_defined_in_molecule_builer : concern_for_PassiveTransportConverter
-   {
-      private IMoBiSimulation _simulation;
-      private TransportBuilder _clonedPassiveTransport;
-
-      protected override void Context()
-      {
-         base.Context();
-         _simulation = A.Fake<IMoBiSimulation>();
-         _simulation.BuildConfiguration.Molecules = _molecules;
-         _simulation.BuildConfiguration.PassiveTransports = _passiveTransports;
-         _clonedPassiveTransport = new TransportBuilder().WithName("PASSIVE TRANSPORT");
-         A.CallTo(() => _cloneManagerForModel.Clone<ITransportBuilder>(_passiveTransport)).Returns(_clonedPassiveTransport);
-      }
-
-      protected override void Because()
-      {
-         sut.Convert(_simulation);
-      }
-
-      [Observation]
-      public void should_add_the_passive_transport_in_the_passive_transport_building_block()
-      {
-         _passiveTransports.ShouldContain(_clonedPassiveTransport);
-      }
-
-      [Observation]
-      public void should_have_renamed_the_passive_transport_to_contain_the_name_of_the_molecule()
-      {
-         _clonedPassiveTransport.Name.ShouldBeEqualTo(AppConstants.CompositeNameFor(_passiveTransport.Name, _moleculeWithPassiveTransport.Name));
-      }
-
-      [Observation]
-      public void the_passive_transport_should_only_transport_the_molecule_builder_it_was_attached_to()
-      {
-         _clonedPassiveTransport.ForAll.ShouldBeFalse();
-         _clonedPassiveTransport.MoleculeNames().ShouldOnlyContain(_moleculeWithPassiveTransport.Name);
-      }
-
-      [Observation]
-      public void should_not_notify_any_warning_or_info()
-      {
-         _showNotificationEvent.ShouldBeNull();
-      }
-   }
-
-   public class When_converting_a_molecule_building_block_using_a_molecule_with_a_passive_transport : concern_for_PassiveTransportConverter
-   {
-      protected override void Because()
-      {
-         sut.Convert(_molecules);
-      }
-
-      [Observation]
-      public void should_have_added_a_new_passive_transport_to_the_project()
-      {
-         _project.PassiveTransportCollection.Count.ShouldBeEqualTo(1);
-      }
-
-      [Observation]
-      public void should_have_named_the_newly_added_passive_transport_after_the_molecule_building_block()
-      {
-         _project.PassiveTransportCollection.ElementAt(0).Name.ShouldBeEqualTo(_molecules.Name);
-      }
-
-      [Observation]
-      public void should_notify_an_info_to_the_user()
-      {
-         _showNotificationEvent.ShouldNotBeNull();
-         _showNotificationEvent.NotificationMessages.Count.ShouldBeEqualTo(1);
-         _showNotificationEvent.NotificationMessages[0].BuildingBlock.ShouldBeEqualTo(_project.PassiveTransportCollection.ElementAt(0));
-      }
-   }
-
-   public class When_converting_a_project : concern_for_PassiveTransportConverter
-   {
-      private IPassiveTransportBuildingBlock _passiveTransports2;
-      protected override void Context()
-      {
-         base.Context();
-         _passiveTransports2 = new PassiveTransportBuildingBlock();
-         _project.AddBuildingBlock(_passiveTransports);
-         _project.AddBuildingBlock(_passiveTransports2);
-         _project.AddBuildingBlock(_molecules);
-
-         var anotherMoleculeWithPassiveTransport = new MoleculeBuilder().WithName("MOLECULE");
-         var molecules2 = new MoleculeBuildingBlock {anotherMoleculeWithPassiveTransport}.WithName("MBB2");
-         var samePassiveTransport = new TransportBuilder().WithName("PASSIVE TRANSPORT").WithFormula(A.Fake<IFormula>());
-         anotherMoleculeWithPassiveTransport.Add(samePassiveTransport);
-
-         A.CallTo(() => _formulaTask.FormulasAreTheSame(_passiveTransportKinetic, samePassiveTransport.Formula)).Returns(true);
-
-         A.CallTo(() => _cloneManagerForModel.Clone<ITransportBuilder>(_passiveTransport)).ReturnsLazily(x => new TransportBuilder().WithFormula(_passiveTransportKinetic));
-         A.CallTo(() => _containerTask.CreateUniqueName(_passiveTransports, A<string>._, true)).ReturnsLazily(x => x.Arguments[1].ConvertedTo<string>());
-         _project.AddBuildingBlock(molecules2);
-      }
-
-      protected override void Because()
-      {
-         sut.Convert(_project);
-      }
-
-      [Observation]
-      public void should_have_added_all_passive_transport_of_all_molecules_in_all_passive_transport_building_blocks()
-      {
-         _passiveTransports.Count().ShouldBeEqualTo(1);
-         _passiveTransports2.Count().ShouldBeEqualTo(1);
-         Assert.AreNotSame(_passiveTransports.First(),_passiveTransports2.First());
-      }
-   }
-}
\ No newline at end of file
diff --git a/tests/MoBi.Tests/Core/Service/SerializationTasksSpecs.cs b/tests/MoBi.Tests/Core/Service/SerializationTasksSpecs.cs
index 51e3c3ad6..19814c876 100644
--- a/tests/MoBi.Tests/Core/Service/SerializationTasksSpecs.cs
+++ b/tests/MoBi.Tests/Core/Service/SerializationTasksSpecs.cs
@@ -31,7 +31,7 @@ public abstract class concern_for_SerializationTask : ContextSpecification<Seria
       protected IProjectConverterLogger _converterLogger;
       protected IMoBiContext _context;
       protected IPostSerializationStepsMaker _postSerializationSteps;
-      protected IHeavyWorkManager _heavyworkManager;
+      protected IHeavyWorkManager _heavyWorkManager;
       protected string _fileToOpen;
       private Func<string, bool> _oldFileExists;
 
@@ -44,9 +44,9 @@ protected override void Context()
          _converterLogger = A.Fake<IProjectConverterLogger>();
          _context = A.Fake<IMoBiContext>();
          _postSerializationSteps = A.Fake<IPostSerializationStepsMaker>();
-         _heavyworkManager = new HeavyWorkManagerForSpecs();
+         _heavyWorkManager = new HeavyWorkManagerForSpecs();
          sut = new SerializationTask(_serializationService, _contextPersistor, new ObjectTypeResolver(), _dialogCreator, _contentSelector, _converterLogger,
-            _context, _postSerializationSteps, _heavyworkManager);
+            _context, _postSerializationSteps, _heavyWorkManager);
 
 
          _fileToOpen = "toto.mbp3";
@@ -78,7 +78,7 @@ protected override void Because()
       }
 
       [Observation]
-      public void should_return_the_desieriliezed_objects()
+      public void should_return_the_deserialized_objects()
       {
          _result.ShouldNotBeNull();
       }
@@ -112,7 +112,7 @@ protected override void Because()
       [Observation]
       public void should_notify_that_the_project_is_already_open()
       {
-         A.CallTo(() => _dialogCreator.MessageBoxYesNo(A<string>._, AppConstants.Captions.OpenAnyway, AppConstants.Captions.CancelButton)).MustHaveHappened();
+         A.CallTo(() => _dialogCreator.MessageBoxYesNo(A<string>._, AppConstants.Captions.OpenAnyway, AppConstants.Captions.CancelButton, ViewResult.Yes)).MustHaveHappened();
       }
    }
 
diff --git a/tests/MoBi.Tests/Core/Service/SimulationCommitToBuildingBlockTasksSpecs.cs b/tests/MoBi.Tests/Core/Service/SimulationCommitToBuildingBlockTasksSpecs.cs
deleted file mode 100644
index 9068aa4d7..000000000
--- a/tests/MoBi.Tests/Core/Service/SimulationCommitToBuildingBlockTasksSpecs.cs
+++ /dev/null
@@ -1,97 +0,0 @@
-using FakeItEasy;
-
-using BTS.BDDHelper;
-using BTS.BDDHelper.Extensions;
-using MoBi.Core.Commands;
-using MoBi.Core.Domain.Model;
-using MoBi.Core.Services;
-using SBSuite.Core.Domain;
-using SBSuite.Core.Domain.Builder;
-
-using SBSuite.Core.Domain.Services;
-
-
-namespace MoBi.Core.Service
-{
-   public abstract class concern_for_SimulationCommitToBuildingBlockTasksSpecs : ContextSpecification<ISimulationCommitToBuildingBlockTasks>
-   {
-      protected ICreateCommitChangesToBuildingBlockCommandTaskRetriever _taskRetriever;
-      protected ICloneManagerForBuildingBlock _cloneManagerForBuildingBlock;
-
-
-      protected override void Context()
-      {
-         _taskRetriever = A.Fake<ICreateCommitChangesToBuildingBlockCommandTaskRetriever>();
-         _cloneManagerForBuildingBlock = A.Fake<ICloneManagerForBuildingBlock>();
-         sut = new SimulationCommitToBuildingBlockTasks(_taskRetriever,_cloneManagerForBuildingBlock);
-      }
-   }
-
-   class When_tell_a_SimulationCommitToBuildingBlockTasks_to_CommitChanges : concern_for_SimulationCommitToBuildingBlockTasksSpecs
-   {
-      private IMoBiSimulation _simulation;
-      private IBuildingBlock _buildingBlock;
-      private IMoBiCommand _resultCommand;
-
-      protected override void Context()
-      {
-         base.Context();
-         _simulation = A.Fake<IMoBiSimulation>();
-         A.CallTo(() => _simulation.MoBiBuildConfiguration).Returns( A.Fake<IMoBiBuildConfiguration>());
-         _buildingBlock = A.Fake<IBuildingBlock>();
-         var buildingBlockTask = A.Fake<ICreateCommitChangesToBuildingBlockCommandTask>();
-         A.CallTo(() => _taskRetriever.TaskFor(_buildingBlock)).Returns(buildingBlockTask);
-         A.CallTo(() => buildingBlockTask.CreateCommitToBuildingBlockCommand(_simulation,_buildingBlock)).Returns(A.Fake<IMoBiCommand>());
-      }
-
-      protected override void Because()
-      {
-         _resultCommand=sut.CommitSimulaitionChangesToBuildingBlock(_simulation, _buildingBlock);
-      }
-
-      [Observation]
-      public void should_ask_for_building_block_specific_creat_command_task()
-      {
-         A.CallTo(() => _taskRetriever.TaskFor(_buildingBlock)).MustHaveHappened();
-      }
-
-      [Observation]
-      public void should_return_macroCommand_conntaining_nessary_commands()
-      {
-         var macroCommand = _resultCommand as IMoBiMacroCommand;
-         macroCommand.ShouldNotBeNull();
-         macroCommand.Count.ShouldBeEqualTo(2);
-         //TODO retrieve single Commands To Check
-      }
-
-   }
-
-   class When_to_a_SimulationCommitToBuildingBlockTasks_an_empty_command_was_given_by_sub_task : concern_for_SimulationCommitToBuildingBlockTasksSpecs
-   {
-      private IMoBiSimulation _simulation;
-      private IBuildingBlock _buildingBlock;
-      private IMoBiCommand _resultCommand;
-
-      protected override void Context()
-      {
-         base.Context();
-         _simulation = A.Fake<IMoBiSimulation>();
-         _buildingBlock = A.Fake<IBuildingBlock>();
-         var buildingBlockTask = A.Fake<ICreateCommitChangesToBuildingBlockCommandTask>();
-         A.CallTo(() => _taskRetriever.TaskFor(_buildingBlock)).Returns(buildingBlockTask);
-         A.CallTo(() => buildingBlockTask.CreateCommitToBuildingBlockCommand(_simulation, _buildingBlock)).Returns(new MoBiEmptyCommand());
-      }
-
-      protected override void Because()
-      {
-         _resultCommand = sut.CommitSimulaitionChangesToBuildingBlock(_simulation, _buildingBlock);
-      }
-
-      [Observation]
-      public void should_return_empty_command()
-      {
-         _resultCommand.ShouldBeAnInstanceOf<MoBiEmptyCommand>();
-      }
-
-   }
-}	
\ No newline at end of file
diff --git a/tests/MoBi.Tests/Core/SessionFactoryProviderSpecs.cs b/tests/MoBi.Tests/Core/SessionFactoryProviderSpecs.cs
index 2751a1975..772d94a53 100644
--- a/tests/MoBi.Tests/Core/SessionFactoryProviderSpecs.cs
+++ b/tests/MoBi.Tests/Core/SessionFactoryProviderSpecs.cs
@@ -1,6 +1,6 @@
 using OSPSuite.BDDHelper;
 using MoBi.Core.Serialization.ORM.MetaData;
-using OSPSuite.Infrastructure.Services;
+using OSPSuite.Infrastructure.Serialization.Services;
 
 namespace MoBi.Core
 {
diff --git a/tests/MoBi.Tests/Helpers/DiagramModelToXmlMapperForSpecs.cs b/tests/MoBi.Tests/Helpers/DiagramModelToXmlMapperForSpecs.cs
new file mode 100644
index 000000000..efa5b9e8b
--- /dev/null
+++ b/tests/MoBi.Tests/Helpers/DiagramModelToXmlMapperForSpecs.cs
@@ -0,0 +1,184 @@
+using System.Collections.Generic;
+using System.Drawing;
+using System.Linq;
+using System.Xml;
+using OSPSuite.Core.Diagram;
+using OSPSuite.Core.Serialization.Diagram;
+
+namespace MoBi.Helpers
+{
+   public class DiagramModelToXmlMapperForSpecs : IDiagramModelToXmlMapper
+   {
+      public IDiagramModel XmlDocumentToDiagramModel(XmlDocument xmlDoc)
+      {
+         return new DiagramModelForSpecs();
+      }
+
+      public XmlDocument DiagramModelToXmlDocument(IDiagramModel diagramModel)
+      {
+         var doc = new XmlDocument();
+         doc.AppendChild(doc.CreateElement(ElementName));
+         return doc;
+      }
+
+      public void Deserialize(IDiagramModel model, XmlDocument xmlDoc)
+      {
+
+      }
+
+      public void AddElementBaseNodeBindingFor<T>(T node)
+      {
+
+      }
+
+      public string ElementName => "DiagramModel";
+   }
+
+   public class DiagramModelForSpecs : IDiagramModel
+   {
+      public PointF Location { get; set; }
+      public PointF Center { get; set; }
+      public SizeF Size { get; set; }
+      public RectangleF Bounds { get; set; }
+
+      public IEnumerable<T> GetDirectChildren<T>() where T : class
+      {
+         return Enumerable.Empty<T>();
+      }
+
+      public IEnumerable<T> GetAllChildren<T>() where T : class
+      {
+         return Enumerable.Empty<T>();
+      }
+
+      public void AddChildNode(IBaseNode node)
+      {
+      }
+
+      public void RemoveChildNode(IBaseNode node)
+      {
+      }
+
+      public bool ContainsChildNode(IBaseNode node, bool recursive)
+      {
+         return false;
+      }
+
+      public RectangleF CalculateBounds()
+      {
+         return new RectangleF(0, 0, 10, 10);
+      }
+
+      public void SetHiddenRecursive(bool hidden)
+      {
+      }
+
+      public void PostLayoutStep()
+      {
+      }
+
+      public void Collapse(int level)
+      {
+      }
+
+      public void Expand(int level)
+      {
+      }
+
+      public IBaseNode GetNode(string id)
+      {
+         return null;
+      }
+
+      public T GetNode<T>(string id) where T : class, IBaseNode
+      {
+         return null;
+      }
+
+      public T CreateNode<T>(string id, PointF location, IContainerBase parentContainerBase) where T : class, IBaseNode, new()
+      {
+         return new T();
+      }
+
+      public void RemoveNode(string id)
+      {
+      }
+
+      public void RenameNode(string id, string name)
+      {
+      }
+
+      public IDiagramModel CreateCopy(string containerId = null)
+      {
+         return new DiagramModelForSpecs();
+      }
+
+      public void ReplaceNodeIds(IDictionary<string, string> changedIds)
+      {
+      }
+
+      public bool IsEmpty()
+      {
+         return true;
+      }
+
+      public void Clear()
+      {
+      }
+
+      public void SetDefaultExpansion()
+      {
+      }
+
+      public void RefreshSize()
+      {
+      }
+
+      public void Undo()
+      {
+      }
+
+      public void ClearUndoStack()
+      {
+      }
+
+      public void BeginUpdate()
+      {
+      }
+
+      public void EndUpdate()
+      {
+      }
+
+      public bool StartTransaction()
+      {
+         return true;
+      }
+
+      public bool FinishTransaction(string layoutrecursivedone)
+      {
+         return true;
+      }
+
+      public void ShowDefaultExpansion()
+      {
+      }
+
+      public IBaseNode FindByName(string name)
+      {
+         return null;
+      }
+
+      public void AddNodeId(IBaseNode baseNode)
+      {
+      }
+
+      public bool IsLayouted { get; set; }
+      public IDiagramOptions DiagramOptions { get; set; }
+      public IDiagramModel Create()
+      {
+         return new DiagramModelForSpecs();
+      }
+   }
+
+}
\ No newline at end of file
diff --git a/tests/MoBi.Tests/Helpers/DomainFactoryForSpecs.cs b/tests/MoBi.Tests/Helpers/DomainFactoryForSpecs.cs
index 788f3566d..939534846 100644
--- a/tests/MoBi.Tests/Helpers/DomainFactoryForSpecs.cs
+++ b/tests/MoBi.Tests/Helpers/DomainFactoryForSpecs.cs
@@ -86,7 +86,7 @@ public static IMoleculeStartValuesBuildingBlock CreateMoleculeStartValuesFor(IMo
          return startValuesCreator.CreateFrom(buildConfiguration.MoBiSpatialStructure, buildConfiguration.Molecules);
       }
 
-      public static IDimension AmountDimension => DimensionByName(Constants.Dimension.AMOUNT);
+      public static IDimension AmountDimension => DimensionByName(Constants.Dimension.MOLAR_AMOUNT);
 
       public static IDimension DimensionByName(string dimensionName) => IoC.Resolve<IDimensionFactory>().Dimension(dimensionName);
    }
diff --git a/tests/MoBi.Tests/Helpers/DomainHelperForSpecs.cs b/tests/MoBi.Tests/Helpers/DomainHelperForSpecs.cs
index c0b2019ab..d13a6371a 100644
--- a/tests/MoBi.Tests/Helpers/DomainHelperForSpecs.cs
+++ b/tests/MoBi.Tests/Helpers/DomainHelperForSpecs.cs
@@ -21,11 +21,11 @@ static DomainHelperForSpecs()
       /// <returns>The full path including the name and extension</returns>
       public static string TestFileFullPath(string fileName)
       {
-         var dataFolder = Path.Combine(AppDomain.CurrentDomain.BaseDirectory, "..", "..", "TestFiles");
+         var dataFolder = Path.Combine(AppDomain.CurrentDomain.BaseDirectory, "..", "..", "..", "TestFiles");
          return Path.Combine(dataFolder, fileName);
       }
 
-      public static IDimension AmountDimension { get; } = new Dimension(new BaseDimensionRepresentation {AmountExponent = 1}, Constants.Dimension.AMOUNT, "µmol");
+      public static IDimension AmountDimension { get; } = new Dimension(new BaseDimensionRepresentation {AmountExponent = 1}, Constants.Dimension.MOLAR_AMOUNT, "µmol");
 
       public static IDimension ConcentrationDimension { get; } = new Dimension(new BaseDimensionRepresentation {LengthExponent = -3, MassExponent = 1, TimeExponent = -1}, Constants.Dimension.MOLAR_CONCENTRATION, "µmol/l");
 
diff --git a/tests/MoBi.Tests/IntegrationTests/ContextForIntegration.cs b/tests/MoBi.Tests/IntegrationTests/ContextForIntegration.cs
index 47e195c46..3e4802d11 100644
--- a/tests/MoBi.Tests/IntegrationTests/ContextForIntegration.cs
+++ b/tests/MoBi.Tests/IntegrationTests/ContextForIntegration.cs
@@ -4,17 +4,15 @@
 using Castle.Facilities.TypedFactory;
 using FakeItEasy;
 using MoBi.Assets;
-using MoBi.BatchTool.Services;
 using MoBi.Core;
 using MoBi.Core.Commands;
 using MoBi.Core.Domain.Model;
 using MoBi.Core.Domain.Model.Diagram;
 using MoBi.Core.Domain.Services;
-using MoBi.Core.SBML;
 using MoBi.Core.Serialization.Xml.Services;
 using MoBi.Core.Services;
 using MoBi.Engine;
-using MoBi.Engine.Sbml;
+using MoBi.Helpers;
 using MoBi.Presentation;
 using MoBi.Presentation.Presenter;
 using MoBi.Presentation.Serialization;
@@ -23,7 +21,6 @@
 using MoBi.UI.Services;
 using OSPSuite.BDDHelper;
 using OSPSuite.Core;
-using OSPSuite.Core.Commands;
 using OSPSuite.Core.Diagram;
 using OSPSuite.Core.Domain;
 using OSPSuite.Core.Journal;
@@ -81,7 +78,7 @@ public override void GlobalContext()
             container.RegisterImplementationOf(A.Fake<IContainerBaseLayouter>());
             container.RegisterImplementationOf(A.Fake<ILayerLayouter>());
 
-            container.Register<IDiagramModelToXmlMapper, BatchDiagramModelToXmlMapper>();
+            container.Register<IDiagramModelToXmlMapper, DiagramModelToXmlMapperForSpecs>();
             container.Register<IMoBiConfiguration, MoBiConfiguration>(LifeStyle.Singleton);
             container.Register<IEventPublisher, EventPublisher>(LifeStyle.Singleton);
             IHeavyWorkManager heavyWorkManager = new HeavyWorkManagerForSpecs();
diff --git a/tests/MoBi.Tests/IntegrationTests/ProjectTaskIntegrationTests.cs b/tests/MoBi.Tests/IntegrationTests/ProjectTaskIntegrationTests.cs
index 3d2d8f6c4..0f2937486 100644
--- a/tests/MoBi.Tests/IntegrationTests/ProjectTaskIntegrationTests.cs
+++ b/tests/MoBi.Tests/IntegrationTests/ProjectTaskIntegrationTests.cs
@@ -1,14 +1,14 @@
 using System;
 using System.IO;
+using MoBi.Core.Domain.Model;
+using MoBi.Presentation.Tasks;
 using OSPSuite.BDDHelper;
 using OSPSuite.BDDHelper.Extensions;
 using OSPSuite.Utility.Container;
-using MoBi.Core.Domain.Model;
-using MoBi.Presentation.Tasks;
 
 namespace MoBi.IntegrationTests
 {
-   public class LoadProjectIntegrationTest : ContextForIntegration<IProjectTask>
+   public class LoadProjectIntegrationTest : ContextWithLoadedProject
    {
       private IMoBiContext _context;
 
@@ -16,8 +16,7 @@ public override void GlobalContext()
       {
          base.GlobalContext();
          _context = IoC.Resolve<IMoBiContext>();
-         sut = IoC.Resolve<IProjectTask>();
-         sut.OpenProjectFrom(Path.Combine(AppDomain.CurrentDomain.BaseDirectory, "..\\..\\TestFiles\\PK_Manual_Diclofenac.mbp3"));
+         LoadProject("PK_Manual_Diclofenac");
       }
 
       [Observation]
diff --git a/tests/MoBi.Tests/IntegrationTests/ReportingSpecs.cs b/tests/MoBi.Tests/IntegrationTests/ReportingSpecs.cs
index 35877fbb5..9e22c23b9 100644
--- a/tests/MoBi.Tests/IntegrationTests/ReportingSpecs.cs
+++ b/tests/MoBi.Tests/IntegrationTests/ReportingSpecs.cs
@@ -3,7 +3,6 @@
 using System.Linq;
 using OSPSuite.BDDHelper;
 using OSPSuite.BDDHelper.Extensions;
-using OSPSuite.TeXReporting;
 using OSPSuite.Utility;
 using OSPSuite.Utility.Container;
 using MoBi.Core.Domain.Model;
@@ -45,7 +44,7 @@ public override void GlobalContext()
 
       private static string TEXTemplateFolder()
       {
-         return Path.Combine(AppDomain.CurrentDomain.BaseDirectory, "..", "..\\Templates", "StandardTemplate");
+         return Path.Combine(AppDomain.CurrentDomain.BaseDirectory, "TeXTemplates", "StandardTemplate");
       }
 
       public void CreateReportAndValidate(IObjectBase objectBase)
@@ -55,7 +54,7 @@ public void CreateReportAndValidate(IObjectBase objectBase)
 
       public void CreateReportAndValidate(object objectToReport, string reportName)
       {
-         _reportConfiguration.ReportFile = Path.Combine(_reportsDir.FullName, string.Format("{0}.pdf", reportName));
+         _reportConfiguration.ReportFile = Path.Combine(_reportsDir.FullName, $"{reportName}.pdf");
          _reportConfiguration.SubTitle = reportName;
          _reportingTask.CreateReportAsync(objectToReport, _reportConfiguration).Wait();
          FileHelper.FileExists(_reportConfiguration.ReportFile).ShouldBeTrue();
diff --git a/tests/MoBi.Tests/IntegrationTests/SBMLTestSuiteSpecs.cs b/tests/MoBi.Tests/IntegrationTests/SBMLTestSuiteSpecs.cs
index 6b374554a..a3809ef65 100644
--- a/tests/MoBi.Tests/IntegrationTests/SBMLTestSuiteSpecs.cs
+++ b/tests/MoBi.Tests/IntegrationTests/SBMLTestSuiteSpecs.cs
@@ -20,7 +20,6 @@
 using OSPSuite.Core.Domain.Services;
 using OSPSuite.Core.Serialization.SimModel.Services;
 using OSPSuite.Core.Services;
-using OSPSuite.Engine.Domain;
 using OSPSuite.Utility.Container;
 using OSPSuite.Utility.Extensions;
 
@@ -32,7 +31,7 @@ public class SBMLTestSuiteSpecs : ContextForSBMLIntegration<ISbmlTask>
       private IBuildConfigurationFactory _buildConfigurationFactory;
       private IModelConstructor _modelConstructor;
       private ISimModelExporter _simModelExporter;
-      private IDataRepositoryTask _dateRepositoryTask;
+      private IDataRepositoryExportTask _dateRepositoryTask;
 
       protected override void Context()
       {
@@ -41,7 +40,7 @@ protected override void Context()
          _buildConfigurationFactory = IoC.Resolve<IBuildConfigurationFactory>();
          _modelConstructor = IoC.Resolve<IModelConstructor>();
          _simModelExporter = IoC.Resolve<ISimModelExporter>();
-         _dateRepositoryTask = IoC.Resolve<IDataRepositoryTask>();
+         _dateRepositoryTask = IoC.Resolve<IDataRepositoryExportTask>();
          _directory = Path.Combine(Path.Combine(Path.Combine(Path.Combine(Path.Combine(AppDomain.CurrentDomain.BaseDirectory, "..\\.."), "Core", "SBML", "Testfiles", "SBMLTestSuite"))));
       }
 
@@ -88,7 +87,7 @@ public void should_be_able_to_read_all_files_and_run_the_most()
 
             var simulation = new MoBiSimulation {BuildConfiguration = buildConfigurtion, Model = result.Model};
             var simModelManager = new SimModelManager(_simModelExporter, new SimModelSimulationFactory(),
-               new DataFactory(IoC.Resolve<IMoBiDimensionFactory>(), new SBMLTestDataNamingService(), IoC.Resolve<IObjectPathFactory>(), IoC.Resolve<IDisplayUnitRetriever>(), IoC.Resolve<IDataRepositoryTask>()));
+               new DataFactory(IoC.Resolve<IMoBiDimensionFactory>(), IoC.Resolve<IObjectPathFactory>(), IoC.Resolve<IDisplayUnitRetriever>(), IoC.Resolve<IDataRepositoryTask>()));
             var runResults = simModelManager.RunSimulation(simulation);
             if (!runResults.Success)
             {
@@ -140,22 +139,4 @@ private void addjEmptyBBIfneeded(IMoBiProject project)
             project.AddBuildingBlock(new ParameterStartValuesBuildingBlock().WithName("Empty"));
       }
    }
-
-   internal class SBMLTestDataNamingService : IDataNamingService
-   {
-      public string GetTimeName()
-      {
-         return AppConstants.TimeColumName;
-      }
-
-      public string GetNewRepositoryName()
-      {
-         return "results";
-      }
-
-      public string GetEntityName(string id)
-      {
-         return id;
-      }
-   }
 }
\ No newline at end of file
diff --git a/tests/MoBi.Tests/MoBi.Tests.csproj b/tests/MoBi.Tests/MoBi.Tests.csproj
index 8fff55e54..62e531f37 100644
--- a/tests/MoBi.Tests/MoBi.Tests.csproj
+++ b/tests/MoBi.Tests/MoBi.Tests.csproj
@@ -1,754 +1,98 @@
-<?xml version="1.0" encoding="utf-8"?>
-<Project ToolsVersion="12.0" DefaultTargets="Build" xmlns="http://schemas.microsoft.com/developer/msbuild/2003">
-  <Import Project="..\..\packages\NUnit.3.11.0\build\NUnit.props" Condition="Exists('..\..\packages\NUnit.3.11.0\build\NUnit.props')" />
+<Project Sdk="Microsoft.NET.Sdk">
+
   <PropertyGroup>
-    <Configuration Condition=" '$(Configuration)' == '' ">Debug</Configuration>
-    <Platform Condition=" '$(Platform)' == '' ">AnyCPU</Platform>
-    <ProductVersion>9.0.21022</ProductVersion>
-    <SchemaVersion>2.0</SchemaVersion>
-    <ProjectGuid>{9DFDB6C9-FB74-4578-AAAF-F89C07BD4414}</ProjectGuid>
-    <OutputType>Library</OutputType>
-    <AppDesignerFolder>Properties</AppDesignerFolder>
+    <TargetFramework>net472</TargetFramework>
+
+    <IsPackable>false</IsPackable>
+
     <RootNamespace>MoBi</RootNamespace>
-    <AssemblyName>MoBi.Tests</AssemblyName>
-    <TargetFrameworkVersion>v4.6.2</TargetFrameworkVersion>
-    <FileAlignment>512</FileAlignment>
-    <FileUpgradeFlags>
-    </FileUpgradeFlags>
-    <UpgradeBackupLocation>
-    </UpgradeBackupLocation>
-    <OldToolsVersion>3.5</OldToolsVersion>
-    <TargetFrameworkProfile />
-    <NuGetPackageImportStamp>
-    </NuGetPackageImportStamp>
   </PropertyGroup>
-  <PropertyGroup Condition=" '$(Configuration)|$(Platform)' == 'Debug|AnyCPU' ">
-    <DebugSymbols>true</DebugSymbols>
-    <DebugType>full</DebugType>
-    <Optimize>false</Optimize>
-    <OutputPath>bin\Debug\</OutputPath>
-    <DefineConstants>DEBUG;TRACE</DefineConstants>
-    <ErrorReport>prompt</ErrorReport>
-    <WarningLevel>4</WarningLevel>
+
+  <PropertyGroup Condition="'$(Configuration)|$(Platform)'=='Debug|AnyCPU'">
     <PlatformTarget>x64</PlatformTarget>
-    <Prefer32Bit>false</Prefer32Bit>
-  </PropertyGroup>
-  <PropertyGroup Condition=" '$(Configuration)|$(Platform)' == 'Release|AnyCPU' ">
-    <DebugType>pdbonly</DebugType>
-    <Optimize>true</Optimize>
-    <OutputPath>bin\Release\</OutputPath>
-    <DefineConstants>TRACE</DefineConstants>
-    <ErrorReport>prompt</ErrorReport>
-    <WarningLevel>4</WarningLevel>
-    <Prefer32Bit>false</Prefer32Bit>
   </PropertyGroup>
+
+  <ItemGroup>
+    <Content Include="..\..\dimensions\OSPSuite.Dimensions.xml" Link="OSPSuite.Dimensions.xml">
+      <CopyToOutputDirectory>PreserveNewest</CopyToOutputDirectory>
+    </Content>
+    <Content Include="..\..\pkparameters\OSPSuite.PKParameters.xml" Link="OSPSuite.PKParameters.xml">
+      <CopyToOutputDirectory>PreserveNewest</CopyToOutputDirectory>
+    </Content>
+    <Content Include="$(PkgOSPSuite_FuncParser)\OSPSuite.FuncParserNative\bin\native\x64\Release\OSPSuite.FuncParserNative.dll" Link="OSPSuite.FuncParserNative.dll">
+      <CopyToOutputDirectory>PreserveNewest</CopyToOutputDirectory>
+    </Content>
+    <Content Include="$(PkgOSPSuite_SimModel)\OSPSuite.SimModelNative\bin\native\x64\Release\OSPSuite.SimModelNative.dll" Link="OSPSuite.SimModelNative.dll">
+      <CopyToOutputDirectory>PreserveNewest</CopyToOutputDirectory>
+    </Content>
+    <Content Include="$(PkgOSPSuite_SimModelSolver_CVODES)\OSPSuite.SimModelSolver_CVODES\bin\native\x64\Release\OSPSuite.SimModelSolver_CVODES.dll" Link="OSPSuite.SimModelSolver_CVODES.dll">
+      <CopyToOutputDirectory>PreserveNewest</CopyToOutputDirectory>
+    </Content>
+    <Content Include="$(PkgSystem_Data_SQLite_Core)\build\net46\x64\SQLite.Interop.dll" Link="SQLite.Interop.dll">
+      <CopyToOutputDirectory>PreserveNewest</CopyToOutputDirectory>
+    </Content>
+    <Content Include="$(PkgOSPSuite_TeXReporting)\OSPSuite.TeXReporting\**">
+      <CopyToOutputDirectory>PreserveNewest</CopyToOutputDirectory>
+    </Content>
+  </ItemGroup>
+
+  <ItemGroup>
+    <PackageReference Include="FakeItEasy" Version="6.0.0" />
+    <PackageReference Include="NUnit3TestAdapter" Version="3.16.1">
+      <PrivateAssets>all</PrivateAssets>
+      <IncludeAssets>runtime; build; native; contentfiles; analyzers; buildtransitive</IncludeAssets>
+    </PackageReference>
+    <PackageReference Include="Microsoft.NET.Test.Sdk" Version="16.4.0" />
+    <PackageReference Include="nunit" Version="3.12.0" />
+    <PackageReference Include="OSPSuite.BDDHelper" Version="4.0.0.1" />
+    <PackageReference Include="OSPSuite.Core" Version="9.0.137" />
+    <PackageReference Include="OSPSuite.Infrastructure" Version="9.0.137" />
+    <PackageReference Include="OSPSuite.Infrastructure.Castle" Version="9.0.137" />
+    <PackageReference Include="OSPSuite.UI" Version="9.0.137" />
+    <PackageReference Include="OSPSuite.FuncParser" Version="4.0.0.50" GeneratePathProperty="true" />
+    <PackageReference Include="OSPSuite.SimModel" Version="4.0.0.42" GeneratePathProperty="true" />
+    <PackageReference Include="OSPSuite.SimModelSolver_CVODES" Version="4.1.0.8" GeneratePathProperty="true" />
+    <PackageReference Include="System.Data.SQLite.Core" Version="1.0.112" GeneratePathProperty="true" />
+    <PackageReference Include="OSPSuite.TeXReporting" Version="3.0.0.4" GeneratePathProperty="true" />
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+
+  <ItemGroup>
+    <ProjectReference Include="..\..\src\MoBi.Core\MoBi.Core.csproj" />
+    <ProjectReference Include="..\..\src\MoBi.Engine\MoBi.Engine.csproj" />
+    <ProjectReference Include="..\..\src\MoBi.Presentation\MoBi.Presentation.csproj" />
+    <ProjectReference Include="..\..\src\MoBi.UI\MoBi.UI.csproj" />
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-    <Compile Include="Presentation\EditTableFormulaPresenterSpecs.cs" />
-    <Compile Include="Presentation\ParameterDTOSpecs.cs" />
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-    <Compile Include="Presentation\ExportModelPartsToExcelUICommandSpecs.cs" />
-    <Compile Include="Presentation\EditExplicitFormulaPresenterSpecs.cs" />
-    <Compile Include="Presentation\FormulaPresenterCacheSpecs.cs" />
-    <Compile Include="Presentation\HierarchicalStructurePresenterSpecs.cs" />
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-    <Compile Include="Presentation\ImportParameterStartValuesPresenterSpecs.cs" />
-    <Compile Include="Presentation\ImportQuantitiesForSimulationPresenterSpecs.cs" />
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-    <Compile Include="Presentation\InteractionTasksForSpatialStructureSpecs.cs" />
-    <Compile Include="Presentation\LegendPresenterSpecs.cs" />
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-    <Compile Include="Presentation\Mapper\ExplicitFormulaToExplicitFormulaDTOMapperSpecs.cs" />
-    <Compile Include="Presentation\Mapper\InteractionContainerToDTOInteractionConatainerMapperSpecs.cs" />
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-    <Compile Include="ProjectConversion\v3_5\BuildConfiguration_341Specs.cs" />
-    <Compile Include="ProjectConversion\v3_5\ModelCoreSimulation3_0Specs.cs" />
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-    <Compile Include="ProjectConversion\v6_0\Converter36To601Specs.cs" />
-    <Compile Include="ProjectConversion\v7_3\Converter710To730Specs.cs" />
-    <Compile Include="Properties\AssemblyInfo.cs" />
-    <Compile Include="Presentation\TagVisitorSpecs.cs" />
   </ItemGroup>
+
+
   <ItemGroup>
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-      <Link>OSPSuite.SimModel.xsd</Link>
-      <SubType>Designer</SubType>
-      <CopyToOutputDirectory>PreserveNewest</CopyToOutputDirectory>
+    <None Include="..\..\LICENSE">
+      <Pack>True</Pack>
+      <PackagePath></PackagePath>
     </None>
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-      <Link>AllCalculationMethods.pkml</Link>
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     </None>
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-  </ItemGroup>
-  <ItemGroup>
-    <None Include="..\..\pre\libsbmlcs.dll">
-      <Link>libsbmlcs.dll</Link>
+    <None Include="..\..\src\Data\AllCalculationMethods.pkml" Link="AllCalculationMethods.pkml">
       <CopyToOutputDirectory>PreserveNewest</CopyToOutputDirectory>
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-      <Link>OSPSuite.SimModelSolver_CVODES.dll</Link>
+    <None Include="..\..\src\Data\SpaceOrganismTemplate.mbdt" Link="SpaceOrganismTemplate.mbdt">
       <CopyToOutputDirectory>PreserveNewest</CopyToOutputDirectory>
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-    <Content Include="..\..\pkparameters\OSPSuite.PKParameters.xml">
-      <Link>OSPSuite.PKParameters.xml</Link>
+    </None>
+    <None Include="..\..\src\Data\GroupRepository.xml" Link="GroupRepository.xml">
       <CopyToOutputDirectory>PreserveNewest</CopyToOutputDirectory>
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-    <None Include="TestFiles\MoBiSimulation3_4.pkml">
-      <SubType>Designer</SubType>
     </None>
   </ItemGroup>
+
+
   <ItemGroup>
-    <ProjectReference Include="..\..\src\MoBi.BatchTool\MoBi.BatchTool.csproj">
-      <Project>{881d23db-4a9f-45c8-ba67-58b790537634}</Project>
-      <Name>MoBi.BatchTool</Name>
-    </ProjectReference>
-    <ProjectReference Include="..\..\src\MoBi.Core\MoBi.Core.csproj">
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-      <Project>{de743812-f444-42e2-b72d-cf298933e2ba}</Project>
-      <Name>MoBi.UI</Name>
-    </ProjectReference>
+    <Folder Include="ProjectConversion\v6_0\" />
   </ItemGroup>
-  <ItemGroup />
-  <Import Project="$(MSBuildToolsPath)\Microsoft.CSharp.targets" />
-  <Import Project="..\..\packages\System.Data.SQLite.Core.1.0.110.0\build\net46\System.Data.SQLite.Core.targets" Condition="Exists('..\..\packages\System.Data.SQLite.Core.1.0.110.0\build\net46\System.Data.SQLite.Core.targets')" />
-  <Target Name="EnsureNuGetPackageBuildImports" BeforeTargets="PrepareForBuild">
-    <PropertyGroup>
-      <ErrorText>This project references NuGet package(s) that are missing on this computer. Use NuGet Package Restore to download them.  For more information, see http://go.microsoft.com/fwlink/?LinkID=322105. The missing file is {0}.</ErrorText>
-    </PropertyGroup>
-    <Error Condition="!Exists('..\..\packages\System.Data.SQLite.Core.1.0.110.0\build\net46\System.Data.SQLite.Core.targets')" Text="$([System.String]::Format('$(ErrorText)', '..\..\packages\System.Data.SQLite.Core.1.0.110.0\build\net46\System.Data.SQLite.Core.targets'))" />
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-  </Target>
-  <!-- To modify your build process, add your task inside one of the targets below and uncomment it. 
-       Other similar extension points exist, see Microsoft.Common.targets.
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+
+
 </Project>
\ No newline at end of file
diff --git a/tests/MoBi.Tests/Presentation/DTOValuePointSpecs.cs b/tests/MoBi.Tests/Presentation/DTOValuePointSpecs.cs
index 9d38c15fe..9541ff54b 100644
--- a/tests/MoBi.Tests/Presentation/DTOValuePointSpecs.cs
+++ b/tests/MoBi.Tests/Presentation/DTOValuePointSpecs.cs
@@ -13,7 +13,7 @@ public abstract class concern_for_DTOValuePoint : ContextSpecification<DTOValueP
       protected override void Context()
       {
          _tableFormulaBuilderDTO = new TableFormulaBuilderDTO();
-         var timeDimension = DimensionFactoryForSpecs.Factory.TryGetDimension(DimensionFactoryForSpecs.DimensionNames.Time);
+         var timeDimension = DimensionFactoryForSpecs.Factory.Dimension(DimensionFactoryForSpecs.DimensionNames.Time);
 
          sut = new DTOValuePoint(_tableFormulaBuilderDTO)
          {
diff --git a/tests/MoBi.Tests/Presentation/EditParameterListSpecs.cs b/tests/MoBi.Tests/Presentation/EditParameterListSpecs.cs
index 1f5a69018..3ef3c7519 100644
--- a/tests/MoBi.Tests/Presentation/EditParameterListSpecs.cs
+++ b/tests/MoBi.Tests/Presentation/EditParameterListSpecs.cs
@@ -212,7 +212,7 @@ protected override void Context()
 
       protected override void Because()
       {
-         sut.SetParamterUnit(_parameterDTO, _displayUnit);
+         sut.SetParameterUnit(_parameterDTO, _displayUnit);
       }
 
       [Observation]
@@ -241,7 +241,7 @@ protected override void Context()
 
       protected override void Because()
       {
-         sut.SetParamterUnit(_parameterDTO, _displayUnit);
+         sut.SetParameterUnit(_parameterDTO, _displayUnit);
       }
 
       [Observation]
diff --git a/tests/MoBi.Tests/Presentation/HeavyWorkManagerForSpecs.cs b/tests/MoBi.Tests/Presentation/HeavyWorkManagerForSpecs.cs
index 7c119f043..8b39a794d 100644
--- a/tests/MoBi.Tests/Presentation/HeavyWorkManagerForSpecs.cs
+++ b/tests/MoBi.Tests/Presentation/HeavyWorkManagerForSpecs.cs
@@ -1,5 +1,6 @@
 using System;
 using System.Threading.Tasks;
+using OSPSuite.Core.Services;
 using OSPSuite.Presentation.Services;
 
 namespace MoBi.Presentation
diff --git a/tests/MoBi.Tests/Presentation/InteractionTasksForSimulationSpecs.cs b/tests/MoBi.Tests/Presentation/InteractionTasksForSimulationSpecs.cs
index 11f3bf213..78bdc24db 100644
--- a/tests/MoBi.Tests/Presentation/InteractionTasksForSimulationSpecs.cs
+++ b/tests/MoBi.Tests/Presentation/InteractionTasksForSimulationSpecs.cs
@@ -46,7 +46,7 @@ protected override void Context()
       {
          base.Context();
          _simulations = new List<IMoBiSimulation> { A.Fake<IMoBiSimulation>(), A.Fake<IMoBiSimulation>() };
-         A.CallTo(() => _dialogCreator.MessageBoxYesNo(A<string>._)).Returns(ViewResult.No);
+         A.CallTo(() => _dialogCreator.MessageBoxYesNo(A<string>._, ViewResult.Yes)).Returns(ViewResult.No);
       }
 
       protected override void Because()
@@ -76,7 +76,7 @@ protected override void Context()
       {
          base.Context();
          _simulations = new List<IMoBiSimulation> {A.Fake<IMoBiSimulation>(), A.Fake<IMoBiSimulation>()};
-         A.CallTo(() => _dialogCreator.MessageBoxYesNo(A<string>._)).Returns(ViewResult.Yes);
+         A.CallTo(() => _dialogCreator.MessageBoxYesNo(A<string>._, ViewResult.Yes)).Returns(ViewResult.Yes);
       }
 
       protected override void Because()
diff --git a/tests/MoBi.Tests/Presentation/Mapper/DataTableToImportQuantityDTOMapperForMoleculesSpecs.cs b/tests/MoBi.Tests/Presentation/Mapper/DataTableToImportQuantityDTOMapperForMoleculesSpecs.cs
index b10a48dfe..dc706eec6 100644
--- a/tests/MoBi.Tests/Presentation/Mapper/DataTableToImportQuantityDTOMapperForMoleculesSpecs.cs
+++ b/tests/MoBi.Tests/Presentation/Mapper/DataTableToImportQuantityDTOMapperForMoleculesSpecs.cs
@@ -68,7 +68,7 @@ protected override void Context()
 
          _concentrationDimension = new Dimension(new BaseDimensionRepresentation(), Constants.Dimension.MOLAR_CONCENTRATION, "mol/l");
 
-         _amountDimension = new Dimension(new BaseDimensionRepresentation(), Constants.Dimension.AMOUNT, "mol");
+         _amountDimension = new Dimension(new BaseDimensionRepresentation(), Constants.Dimension.MOLAR_AMOUNT, "mol");
          _amountDimension.AddUnit("mmol", 0.001, 0);
 
          _timeDimension = new Dimension(new BaseDimensionRepresentation(), Constants.Dimension.TIME, "s");
@@ -85,7 +85,7 @@ protected override void Context()
          A.CallTo(() => _dimensionFactory.DimensionForUnit("s")).Returns(_timeDimension);
          A.CallTo(() => _dimensionFactory.DimensionForUnit("")).Throws<Exception>();
 
-         A.CallTo(() => _dimensionFactory.Dimension(Constants.Dimension.AMOUNT)).Returns(_amountDimension);
+         A.CallTo(() => _dimensionFactory.Dimension(Constants.Dimension.MOLAR_AMOUNT)).Returns(_amountDimension);
          A.CallTo(() => _dimensionFactory.Dimension(Constants.Dimension.MOLAR_CONCENTRATION)).Returns(_concentrationDimension);
 
          A.CallTo(() => _reactionDimensionRetriever.SelectedDimensionMode).Returns(ReactionDimensionMode.AmountBased);
diff --git a/tests/MoBi.Tests/Presentation/NotificationPresenterSpecs.cs b/tests/MoBi.Tests/Presentation/NotificationPresenterSpecs.cs
index b53cf2ec6..304e59e87 100644
--- a/tests/MoBi.Tests/Presentation/NotificationPresenterSpecs.cs
+++ b/tests/MoBi.Tests/Presentation/NotificationPresenterSpecs.cs
@@ -1,9 +1,5 @@
 using System.Collections.Generic;
 using System.Linq;
-using OSPSuite.BDDHelper;
-using OSPSuite.BDDHelper.Extensions;
-using OSPSuite.Core.Services;
-using OSPSuite.Utility;
 using FakeItEasy;
 using MoBi.Assets;
 using MoBi.Core;
@@ -12,16 +8,20 @@
 using MoBi.Core.Events;
 using MoBi.Core.Helper;
 using MoBi.Core.Services;
-using MoBi.Presentation.Settings;
 using MoBi.Presentation.Mappers;
 using MoBi.Presentation.Presenter.Main;
+using MoBi.Presentation.Settings;
 using MoBi.Presentation.Views;
+using OSPSuite.BDDHelper;
+using OSPSuite.BDDHelper.Extensions;
 using OSPSuite.Core.Domain;
 using OSPSuite.Core.Domain.Builder;
 using OSPSuite.Core.Domain.Formulas;
 using OSPSuite.Core.Events;
+using OSPSuite.Core.Services;
 using OSPSuite.Presentation.Presenters.ContextMenus;
 using OSPSuite.Presentation.Regions;
+using OSPSuite.Utility;
 using OSPSuite.Utility.Collections;
 
 namespace MoBi.Presentation
@@ -57,7 +57,7 @@ protected override void Context()
          _dialogCreator = A.Fake<IDialogCreator>();
          _notificationMessageMapper = new NotificationMessageMapper(new ObjectTypeResolver(), _buildingBlockRetriever);
          A.CallTo(() => _regionResolver.RegionWithName(RegionNames.NotificationList)).Returns(_region);
-         sut = new NotificationPresenter(_view, _regionResolver, _userSettings, _notificationMessageMapper,_viewItemContextMenuFactory,_applicationController,_context,_dialogCreator);
+         sut = new NotificationPresenter(_view, _regionResolver, _userSettings, _notificationMessageMapper, _viewItemContextMenuFactory, _applicationController, _context, _dialogCreator);
          A.CallTo(() => _view.BindTo(A<NotifyList<NotificationMessageDTO>>._))
             .Invokes(x => _allNotifications = x.GetArgument<IEnumerable<NotificationMessageDTO>>(0));
 
@@ -215,7 +215,7 @@ protected override void Because()
       }
 
       [Observation]
-      public void should_only_add_visible_notificaiton()
+      public void should_only_add_visible_notification()
       {
          _allNotifications.Count().ShouldBeEqualTo(1);
       }
@@ -239,7 +239,7 @@ protected override void Context()
          _settingsToUse = NotificationType.Error | NotificationType.Info;
          base.Context();
          _visibleNotification = new NotificationMessageDTO(new NotificationMessage(A.Fake<IObjectBase>(), MessageOrigin.Simulation, A.Fake<IBuildingBlock>(), NotificationType.Error));
-         _hiddenNotification = new NotificationMessageDTO(new NotificationMessage(A.Fake<IObjectBase>(), MessageOrigin.Simulation, A.Fake<IBuildingBlock>(), NotificationType.Warning)); ;
+         _hiddenNotification = new NotificationMessageDTO(new NotificationMessage(A.Fake<IObjectBase>(), MessageOrigin.Simulation, A.Fake<IBuildingBlock>(), NotificationType.Warning));
       }
 
       [Observation]
@@ -265,7 +265,7 @@ protected override void Context()
          base.Context();
          _existingInvalidFormula = A.Fake<IFormula>().WithId("EXISTING");
          _newInvalidFormula = A.Fake<IFormula>().WithId("NEW");
-         sut.Handle(new FormulaInvalidEvent(_existingInvalidFormula, _buildingBlock,"EXISTING OLD"));
+         sut.Handle(new FormulaInvalidEvent(_existingInvalidFormula, _buildingBlock, "EXISTING OLD"));
       }
 
       protected override void Because()
@@ -297,13 +297,13 @@ protected override void Context()
          base.Context();
          _validFormula = A.Fake<IFormula>().WithId("VALID");
          _invalidFormula = A.Fake<IFormula>().WithId("INVALID");
-         sut.Handle(new FormulaInvalidEvent(_validFormula,_buildingBlock, "VALID_MESSAGE"));
-         sut.Handle(new FormulaInvalidEvent(_invalidFormula,_buildingBlock, "INVALID_MESSAGE"));
+         sut.Handle(new FormulaInvalidEvent(_validFormula, _buildingBlock, "VALID_MESSAGE"));
+         sut.Handle(new FormulaInvalidEvent(_invalidFormula, _buildingBlock, "INVALID_MESSAGE"));
       }
 
       protected override void Because()
       {
-         sut.Handle(new FormulaValidEvent(_validFormula,_buildingBlock));
+         sut.Handle(new FormulaValidEvent(_validFormula, _buildingBlock));
       }
 
       [Observation]
@@ -319,7 +319,7 @@ public void should_have_kept_the_other_formula_notification()
       }
    }
 
-   public class When_the_notification_presenter_is_told_to_clear_the_notifcations_of_a_given_origin : concern_for_NotificationPresenter
+   public class When_the_notification_presenter_is_told_to_clear_the_notifications_of_a_given_origin : concern_for_NotificationPresenter
    {
       protected override void Context()
       {
@@ -343,13 +343,13 @@ public void should_remove_the_expected_notification()
       }
    }
 
-   public class When_the_notification_presenter_is_told_to_clear_all_notifcations : concern_for_NotificationPresenter
+   public class When_the_notification_presenter_is_told_to_clear_all_notifications : concern_for_NotificationPresenter
    {
       protected override void Context()
       {
          base.Context();
          var validationResult = new ValidationResult();
-         validationResult.AddMessage(NotificationType.Error, A.Fake<IObjectBase>(),"TOTO");
+         validationResult.AddMessage(NotificationType.Error, A.Fake<IObjectBase>(), "TOTO");
          sut.Handle(new ShowValidationResultsEvent(validationResult));
          sut.Handle(new FormulaInvalidEvent(A.Fake<IFormula>().WithId("INVALID"), _buildingBlock, "INVALID_MESSAGE"));
       }
@@ -372,7 +372,7 @@ protected override void Context()
       {
          base.Context();
          var validationResult = new ValidationResult();
-         validationResult.AddMessage(NotificationType.Error, A.Fake<IObjectBase>(),"TOTO");
+         validationResult.AddMessage(NotificationType.Error, A.Fake<IObjectBase>(), "TOTO");
          sut.Handle(new ShowValidationResultsEvent(validationResult));
          sut.Handle(new FormulaInvalidEvent(A.Fake<IFormula>().WithId("INVALID"), _buildingBlock, "INVALID_MESSAGE"));
       }
@@ -389,7 +389,7 @@ public void should_remove_all_notifications()
       }
    }
 
-   public class When_the_notification_presenter_is_notified_that_an_buildgingblock_was_removed_for_which_a_notification_was_available : concern_for_NotificationPresenter
+   public class When_the_notification_presenter_is_notified_that_an_building_block_was_removed_for_which_a_notification_was_available : concern_for_NotificationPresenter
    {
       protected override void Context()
       {
@@ -435,15 +435,15 @@ public void should_remove_the_notification()
    public class When_the_notification_presenter_is_asked_to_select_the_item_corresponding_to_a_notification : concern_for_NotificationPresenter
    {
       private NotificationMessageDTO _notificationMessage;
-      private IObjectBase _obectBase;
+      private IObjectBase _objectBase;
 
       protected override void Context()
       {
          base.Context();
-         _obectBase = A.Fake<IObjectBase>();
+         _objectBase = A.Fake<IObjectBase>();
          _buildingBlock = A.Fake<IBuildingBlock>();
          A.CallTo(() => _context.HistoryManager).Returns(A.Fake<IMoBiHistoryManager>());
-         _notificationMessage = new NotificationMessageDTO(new NotificationMessage(_obectBase, MessageOrigin.Simulation, _buildingBlock, NotificationType.Error));
+         _notificationMessage = new NotificationMessageDTO(new NotificationMessage(_objectBase, MessageOrigin.Simulation, _buildingBlock, NotificationType.Error));
       }
 
       protected override void Because()
@@ -454,7 +454,7 @@ protected override void Because()
       [Observation]
       public void should_select_the_item_in_the_view()
       {
-         A.CallTo(() => _applicationController.Select(_obectBase, _buildingBlock, _context.HistoryManager)).MustHaveHappened();
+         A.CallTo(() => _applicationController.Select(_objectBase, _buildingBlock, _context.HistoryManager)).MustHaveHappened();
       }
    }
 
@@ -474,7 +474,6 @@ protected override void Because()
       [Observation]
       public void should_not_export_anything()
       {
-         
       }
    }
 
diff --git a/tests/MoBi.Tests/Presentation/ObjectPathCreatorAtReactionParameterSpecs.cs b/tests/MoBi.Tests/Presentation/ObjectPathCreatorAtReactionParameterSpecs.cs
index 34675b56b..702ba781d 100644
--- a/tests/MoBi.Tests/Presentation/ObjectPathCreatorAtReactionParameterSpecs.cs
+++ b/tests/MoBi.Tests/Presentation/ObjectPathCreatorAtReactionParameterSpecs.cs
@@ -161,7 +161,7 @@ protected override void Context()
          base.Context();
          var dimensionFactory = A.Fake<IMoBiDimensionFactory>();
          _rightDimension = A.Fake<IDimension>();
-         A.CallTo(() => dimensionFactory.Dimension(Constants.Dimension.AMOUNT)).Returns(_rightDimension);
+         A.CallTo(() => dimensionFactory.Dimension(Constants.Dimension.MOLAR_AMOUNT)).Returns(_rightDimension);
          A.CallTo(() => _context.DimensionFactory).Returns(dimensionFactory);
          _parameterName = "Para";
          var paramterId = _parameterName;
diff --git a/tests/MoBi.Tests/Presentation/ObjectPathCreatorSpecs.cs b/tests/MoBi.Tests/Presentation/ObjectPathCreatorSpecs.cs
index 1be46cb16..ba95b357f 100644
--- a/tests/MoBi.Tests/Presentation/ObjectPathCreatorSpecs.cs
+++ b/tests/MoBi.Tests/Presentation/ObjectPathCreatorSpecs.cs
@@ -91,7 +91,7 @@ protected override void Context()
             A.CallTo(() => _context.Get<IContainer>(_moleculePropertiesID)).Returns(_moleculeProperties);
             var dimensionFactory = A.Fake<IMoBiDimensionFactory>();
             _rightDimension = A.Fake<IDimension>();
-            A.CallTo(() => dimensionFactory.Dimension(Constants.Dimension.AMOUNT)).Returns(_rightDimension);
+            A.CallTo(() => dimensionFactory.Dimension(Constants.Dimension.MOLAR_AMOUNT)).Returns(_rightDimension);
             A.CallTo(() => _context.DimensionFactory).Returns(dimensionFactory);
             var rootContainer = new Container().WithName(_rootName);
             var parentContainer = new Container().WithName(_parentName);
@@ -137,7 +137,7 @@ protected override void Context()
             A.CallTo(() => _context.Get<IContainer>(_moleculePropertiesID)).Returns(_moleculeProperties);
             var dimensionFactory = A.Fake<IMoBiDimensionFactory>();
             _rightDimension = A.Fake<IDimension>();
-            A.CallTo(() => dimensionFactory.Dimension(Constants.Dimension.AMOUNT)).Returns(_rightDimension);
+            A.CallTo(() => dimensionFactory.Dimension(Constants.Dimension.MOLAR_AMOUNT)).Returns(_rightDimension);
             A.CallTo(() => _context.DimensionFactory).Returns(dimensionFactory);
             var rootContainer = new Container().WithName(_rootName);
             var parentContainer = new Container().WithName(_parentName);
@@ -184,7 +184,7 @@ protected override void Context()
             A.CallTo(() => _context.Get<IContainer>(_moleculePropertiesID)).Returns(_moleculeProperties);
             var dimensionFactory = A.Fake<IMoBiDimensionFactory>();
             _rightDimension = A.Fake<IDimension>();
-            A.CallTo(() => dimensionFactory.Dimension(Constants.Dimension.AMOUNT)).Returns(_rightDimension);
+            A.CallTo(() => dimensionFactory.Dimension(Constants.Dimension.MOLAR_AMOUNT)).Returns(_rightDimension);
             A.CallTo(() => _context.DimensionFactory).Returns(dimensionFactory);
             _parentContainer = new Container().WithName(_parentName);
             _parentContainer.Add(_moleculeProperties);
@@ -531,7 +531,7 @@ protected override void Context()
             base.Context();
             var dimensionFactory = A.Fake<IMoBiDimensionFactory>();
             _rightDimension = A.Fake<IDimension>();
-            A.CallTo(() => dimensionFactory.Dimension(Constants.Dimension.AMOUNT)).Returns(_rightDimension);
+            A.CallTo(() => dimensionFactory.Dimension(Constants.Dimension.MOLAR_AMOUNT)).Returns(_rightDimension);
             A.CallTo(() => _context.DimensionFactory).Returns(dimensionFactory);
             _dtoMolecule = new ObjectBaseDTO().WithId(ObjectPathKeywords.MOLECULE);
 
@@ -567,7 +567,7 @@ protected override void Context()
             base.Context();
             var dimensionFactory = A.Fake<IMoBiDimensionFactory>();
             _rightDimension = A.Fake<IDimension>();
-            A.CallTo(() => dimensionFactory.Dimension(Constants.Dimension.AMOUNT)).Returns(_rightDimension);
+            A.CallTo(() => dimensionFactory.Dimension(Constants.Dimension.MOLAR_AMOUNT)).Returns(_rightDimension);
             A.CallTo(() => _context.DimensionFactory).Returns(dimensionFactory);
             _dtoMoleculeParameter = new DummyParameterDTO().WithId("ID");
             _parameterName = "Para";
@@ -613,7 +613,7 @@ protected override void Context()
          base.Context();
          var dimensionFactory = A.Fake<IMoBiDimensionFactory>();
          _rightDimension = A.Fake<IDimension>();
-         A.CallTo(() => dimensionFactory.Dimension(Constants.Dimension.AMOUNT)).Returns(_rightDimension);
+         A.CallTo(() => dimensionFactory.Dimension(Constants.Dimension.MOLAR_AMOUNT)).Returns(_rightDimension);
          A.CallTo(() => _context.DimensionFactory).Returns(dimensionFactory);
          _parameterName = "Para";
          var paramterId = _parameterName;
@@ -658,7 +658,7 @@ protected override void Context()
             base.Context();
             var dimensionFactory = A.Fake<IMoBiDimensionFactory>();
             _rightDimension = A.Fake<IDimension>();
-            A.CallTo(() => dimensionFactory.Dimension(Constants.Dimension.AMOUNT)).Returns(_rightDimension);
+            A.CallTo(() => dimensionFactory.Dimension(Constants.Dimension.MOLAR_AMOUNT)).Returns(_rightDimension);
             A.CallTo(() => _context.DimensionFactory).Returns(dimensionFactory);
             _parameterName = "Para";
             var paramterId = _parameterName;
@@ -946,7 +946,7 @@ protected override void Context()
             base.Context();
             var dimensionFactory = A.Fake<IMoBiDimensionFactory>();
             _rightDimension = A.Fake<IDimension>();
-            A.CallTo(() => dimensionFactory.Dimension(Constants.Dimension.AMOUNT)).Returns(_rightDimension);
+            A.CallTo(() => dimensionFactory.Dimension(Constants.Dimension.MOLAR_AMOUNT)).Returns(_rightDimension);
             A.CallTo(() => _context.DimensionFactory).Returns(dimensionFactory);
             _parameterName = "Para";
             var paramterId = _parameterName;
@@ -1001,7 +1001,7 @@ protected override void Context()
           base.Context();
           var dimensionFactory = A.Fake<IMoBiDimensionFactory>();
           _rightDimension = A.Fake<IDimension>();
-          A.CallTo(() => dimensionFactory.Dimension(Constants.Dimension.AMOUNT)).Returns(_rightDimension);
+          A.CallTo(() => dimensionFactory.Dimension(Constants.Dimension.MOLAR_AMOUNT)).Returns(_rightDimension);
           A.CallTo(() => _context.DimensionFactory).Returns(dimensionFactory);
           _parameterName = "Para";
           
diff --git a/tests/MoBi.Tests/Presentation/ProjectTaskSpecs.cs b/tests/MoBi.Tests/Presentation/ProjectTaskSpecs.cs
index 58a4fc8de..80f9e3859 100644
--- a/tests/MoBi.Tests/Presentation/ProjectTaskSpecs.cs
+++ b/tests/MoBi.Tests/Presentation/ProjectTaskSpecs.cs
@@ -293,7 +293,7 @@ protected override void Context()
          _project.HasChanged = true;
          A.CallTo(_dialogCreator).WithReturnType<string>().Returns(string.Empty);
          A.CallTo(() => _context.CurrentProject).Returns(_project);
-         A.CallTo(() => _dialogCreator.MessageBoxYesNoCancel(AppConstants.Dialog.DoYouWantToSaveTheCurrentProject))
+         A.CallTo(() => _dialogCreator.MessageBoxYesNoCancel(AppConstants.Dialog.DoYouWantToSaveTheCurrentProject, ViewResult.Yes))
             .Returns(ViewResult.Yes);
       }
 
@@ -334,7 +334,7 @@ protected override void Context()
          _project.HasChanged = true;
          _project.FilePath = "AA";
          A.CallTo(() => _context.CurrentProject).Returns(_project);
-         A.CallTo(() => _dialogCreator.MessageBoxYesNoCancel(AppConstants.Dialog.DoYouWantToSaveTheCurrentProject))
+         A.CallTo(() => _dialogCreator.MessageBoxYesNoCancel(AppConstants.Dialog.DoYouWantToSaveTheCurrentProject, ViewResult.Yes))
             .Returns(ViewResult.Yes);
       }
 
@@ -353,7 +353,7 @@ public void closing_and_closed_events_should_be_raised_in_order()
       [Observation]
       public void should_ask_if_project_Should_be_closed()
       {
-         A.CallTo(() => _dialogCreator.MessageBoxYesNoCancel(AppConstants.Dialog.DoYouWantToSaveTheCurrentProject))
+         A.CallTo(() => _dialogCreator.MessageBoxYesNoCancel(AppConstants.Dialog.DoYouWantToSaveTheCurrentProject, ViewResult.Yes))
             .MustHaveHappened();
       }
 
@@ -393,7 +393,7 @@ protected override void Context()
          _project = A.Fake<IMoBiProject>();
          _project.HasChanged = true;
          A.CallTo(() => _context.CurrentProject).Returns(_project);
-         A.CallTo(() => _dialogCreator.MessageBoxYesNoCancel(AppConstants.Dialog.DoYouWantToSaveTheCurrentProject))
+         A.CallTo(() => _dialogCreator.MessageBoxYesNoCancel(AppConstants.Dialog.DoYouWantToSaveTheCurrentProject, ViewResult.Yes))
             .Returns(ViewResult.No);
       }
 
@@ -412,7 +412,7 @@ public void closing_and_closed_events_should_be_raised_in_order()
       [Observation]
       public void should_ask_if_project_Should_be_closed()
       {
-         A.CallTo(() => _dialogCreator.MessageBoxYesNoCancel(AppConstants.Dialog.DoYouWantToSaveTheCurrentProject))
+         A.CallTo(() => _dialogCreator.MessageBoxYesNoCancel(AppConstants.Dialog.DoYouWantToSaveTheCurrentProject, ViewResult.Yes))
             .MustHaveHappened();
       }
 
@@ -508,7 +508,7 @@ protected override void Context()
          _oldProject.HasChanged = true;
          _oldProject.FilePath = String.Empty;
          A.CallTo(() => _context.CurrentProject).Returns(_oldProject);
-         A.CallTo(() => _dialogCreator.MessageBoxYesNoCancel(AppConstants.Dialog.DoYouWantToSaveTheCurrentProject))
+         A.CallTo(() => _dialogCreator.MessageBoxYesNoCancel(AppConstants.Dialog.DoYouWantToSaveTheCurrentProject, ViewResult.Yes))
             .Returns(ViewResult.Yes);
          A.CallTo(
             () =>
diff --git a/tests/MoBi.Tests/Presentation/Tasks/EditTasksForSimulationSpecs.cs b/tests/MoBi.Tests/Presentation/Tasks/EditTasksForSimulationSpecs.cs
index a7b93c8ed..08d15c271 100644
--- a/tests/MoBi.Tests/Presentation/Tasks/EditTasksForSimulationSpecs.cs
+++ b/tests/MoBi.Tests/Presentation/Tasks/EditTasksForSimulationSpecs.cs
@@ -21,7 +21,7 @@ public abstract class concern_for_EditTasksForSimulation : ContextSpecification<
       protected IInteractionTaskContext _context;
       private ISimulationPersistor _simulationPersistor;
       private IDialogCreator _dialogCreator;
-      private IDataRepositoryTask _dataRepositoryTask;
+      private IDataRepositoryExportTask _dataRepositoryTask;
       private ISimModelExporter _simulationModelExporter;
       private IModelReportCreator _reportCreator;
       private IDimensionFactory _dimensionFactory;
@@ -32,7 +32,7 @@ protected override void Context()
          _context = A.Fake<IInteractionTaskContext>();
          _simulationPersistor = A.Fake<ISimulationPersistor>();
          _dialogCreator = A.Fake<IDialogCreator>();
-         _dataRepositoryTask = A.Fake<IDataRepositoryTask>();
+         _dataRepositoryTask = A.Fake<IDataRepositoryExportTask>();
          _simulationModelExporter = A.Fake<ISimModelExporter>();
          _reportCreator = A.Fake<IModelReportCreator>();
          _dimensionFactory = A.Fake<IDimensionFactory>();
diff --git a/tests/MoBi.Tests/Presentation/Tasks/ObservedDataTasksSpecs.cs b/tests/MoBi.Tests/Presentation/Tasks/ObservedDataTasksSpecs.cs
index 514fd8718..8e36a6527 100644
--- a/tests/MoBi.Tests/Presentation/Tasks/ObservedDataTasksSpecs.cs
+++ b/tests/MoBi.Tests/Presentation/Tasks/ObservedDataTasksSpecs.cs
@@ -30,7 +30,7 @@ public abstract class concern_for_ObservedDataTask : ContextSpecification<IObser
       protected DataRepository _dataRepository;
       protected IMoBiProject _project;
       private IInteractionTask _interactionTask;
-      private IDataRepositoryTask _dataRepositoryTask;
+      private IDataRepositoryExportTask _dataRepositoryTask;
       protected IContainerTask _containerTask;
       private IObjectTypeResolver _objectTypeResolver;
 
@@ -42,7 +42,7 @@ protected override void Context()
          _dialogCreator = A.Fake<IDialogCreator>();
          _dataRepository = new DataRepository {new BaseGrid("", DimensionFactoryForSpecs.Factory.Dimension("Time"))};
          _interactionTask = A.Fake<IInteractionTask>();
-         _dataRepositoryTask = A.Fake<IDataRepositoryTask>();
+         _dataRepositoryTask = A.Fake<IDataRepositoryExportTask>();
          _containerTask = A.Fake<IContainerTask>();
          _objectTypeResolver = A.Fake<IObjectTypeResolver>();
          sut = new ObservedDataTask(_dataImporter, _dimensionFactory, _context, _dialogCreator, _interactionTask, _dataRepositoryTask, _containerTask, _objectTypeResolver);
@@ -120,7 +120,7 @@ protected override void Context()
       {
          base.Context();
          _project.AddObservedData(_dataRepository);
-         A.CallTo(() => _dialogCreator.MessageBoxYesNo(A<string>._)).Returns(ViewResult.Yes);
+         A.CallTo(() => _dialogCreator.MessageBoxYesNo(A<string>._, ViewResult.Yes)).Returns(ViewResult.Yes);
       }
 
       protected override void Because()
@@ -141,7 +141,7 @@ protected override void Context()
       {
          base.Context();
          _project.AddObservedData(_dataRepository);
-         A.CallTo(() => _dialogCreator.MessageBoxYesNo(A<string>._)).Returns(ViewResult.No);
+         A.CallTo(() => _dialogCreator.MessageBoxYesNo(A<string>._, ViewResult.Yes)).Returns(ViewResult.No);
       }
 
       protected override void Because()
@@ -164,7 +164,7 @@ public class When_addding_data_from_Excel : concern_for_ObservedDataTask
       protected override void Context()
       {
          base.Context();
-         A.CallTo(() => _dimensionFactory.Dimensions).Returns(new []
+         A.CallTo(() => _dimensionFactory.DimensionsSortedByName).Returns(new []
          {
             DimensionFactoryForSpecs.MassDimension,
             DimensionFactoryForSpecs.TimeDimension,
@@ -281,7 +281,7 @@ protected override void Because()
       [Observation]
       public void should_ask_the_user_if_he_really_wants_to_delete_the_results()
       {
-         A.CallTo(() => _dialogCreator.MessageBoxYesNo(AppConstants.Dialog.RemoveAllResultsFrom(_simulation.Name))).MustHaveHappened();
+         A.CallTo(() => _dialogCreator.MessageBoxYesNo(AppConstants.Dialog.RemoveAllResultsFrom(_simulation.Name), ViewResult.Yes)).MustHaveHappened();
       }
 
       [Observation]
@@ -321,7 +321,7 @@ protected override void Because()
       [Observation]
       public void should_ask_the_user_if_he_really_wants_to_delete_the_results()
       {
-         A.CallTo(() => _dialogCreator.MessageBoxYesNo(AppConstants.Dialog.RemoveAllResultsFromProject())).MustHaveHappened();
+         A.CallTo(() => _dialogCreator.MessageBoxYesNo(AppConstants.Dialog.RemoveAllResultsFromProject(), ViewResult.Yes)).MustHaveHappened();
       }
 
       [Observation]
diff --git a/tests/MoBi.Tests/Presentation/Tasks/SimulationRunnerSpecs.cs b/tests/MoBi.Tests/Presentation/Tasks/SimulationRunnerSpecs.cs
index 0a1265bc6..a41e383f5 100644
--- a/tests/MoBi.Tests/Presentation/Tasks/SimulationRunnerSpecs.cs
+++ b/tests/MoBi.Tests/Presentation/Tasks/SimulationRunnerSpecs.cs
@@ -15,8 +15,8 @@
 using OSPSuite.Core.Domain.Formulas;
 using OSPSuite.Core.Domain.Services;
 using OSPSuite.Core.Services;
+using OSPSuite.SimModel;
 using OSPSuite.Utility.Extensions;
-using SimModelNET;
 using ISimulationPersistableUpdater = MoBi.Core.Services.ISimulationPersistableUpdater;
 
 namespace MoBi.Presentation.Tasks
@@ -146,7 +146,7 @@ public void should_record_a_command_to_update_the_new_simulation_output_in_the_s
       [Observation]
       public void should_have_updated_the_simulation_output_selection()
       {
-         _simulation.Settings.OutputSelections.ShouldBeEqualTo(_newOutputSelection);
+         _simulation.SimulationSettings.OutputSelections.ShouldBeEqualTo(_newOutputSelection);
       }
 
       [Observation]
@@ -196,7 +196,7 @@ protected override void Context()
 
          _newResults = new DataRepository("NEW");
          _simulationResults = new SimulationRunResults(success:true, warnings: Enumerable.Empty<SolverWarning>(), results: _newResults);
-         A.CallTo(() => _simModelManager.RunSimulation(_simulation)).Returns(_simulationResults);
+         A.CallTo(() => _simModelManager.RunSimulation(_simulation, null)).Returns(_simulationResults);
          var baseGrid = new BaseGrid("Time", DomainHelperForSpecs.TimeDimension);
           _concentrationColumn = new DataColumn("Drug", DomainHelperForSpecs.ConcentrationDimension, baseGrid);
          _fractionColumn = new DataColumn("Fraction", DomainHelperForSpecs.FractionDimension, baseGrid);
@@ -225,7 +225,7 @@ public void should_update_the_simulation_settings_from_the_selected_output()
       [Observation]
       public void should_run_the_simulation()
       {
-         A.CallTo(() => _simModelManager.RunSimulation(_simulation)).MustHaveHappened();
+         A.CallTo(() => _simModelManager.RunSimulation(_simulation, null)).MustHaveHappened();
       }
 
       [Observation]
diff --git a/tests/MoBi.Tests/ProjectConversion/v3_1/ParameterStarValuesUpdaterSpecs.cs b/tests/MoBi.Tests/ProjectConversion/v3_1/ParameterStarValuesUpdaterSpecs.cs
deleted file mode 100644
index 0b93ea5bf..000000000
--- a/tests/MoBi.Tests/ProjectConversion/v3_1/ParameterStarValuesUpdaterSpecs.cs
+++ /dev/null
@@ -1,86 +0,0 @@
-using System;
-using System.Collections.Generic;
-using FakeItEasy;
-using MoBi.Core.Domain.Model;
-using MoBi.Core.Serialization.Converter;
-using MoBi.Core.Serialization.Converter.v3_1;
-using OSPSuite.BDDHelper;
-using OSPSuite.BDDHelper.Extensions;
-using OSPSuite.Core.Domain;
-using OSPSuite.Core.Domain.Builder;
-using OSPSuite.Core.Domain.UnitSystem;
-
-namespace MoBi.ProjectConversion.v3_1
-{
-   public abstract class concern_for_ParameterStarValuesUpdaterSpecs : ContextSpecification<IParameterStartValuesUpdater>
-   {
-      protected IList<ProjectConverterMessage> _messages;
-      protected IParameterStartValueDimensionRetriever _dimensionRetriever;
-      private IDimensionFactory _dimensionFactory;
-      private IProjectConverterLogger _projectConverterLogger;
-
-      protected override void Context()
-      {
-         _dimensionRetriever = A.Fake<IParameterStartValueDimensionRetriever>();
-         _dimensionFactory = A.Fake<IDimensionFactory>();
-         _projectConverterLogger = A.Fake<IProjectConverterLogger>();
-         sut = new ParameterStartValuesUpdater(_dimensionRetriever, _dimensionFactory, _projectConverterLogger);
-      }
-   }
-
-   internal class When_updating_a_psvbb_to_Version_3_1_3 : concern_for_ParameterStarValuesUpdaterSpecs
-   {
-      private IParameterStartValuesBuildingBlock _psvbb;
-      private IParameterStartValue _psv1;
-      private IParameterStartValue _psv2;
-      private IParameterStartValue _psv3;
-      private IDimension _dim;
-      private double _startValue;
-      private IMoBiProject _project;
-
-      protected override void Context()
-      {
-         base.Context();
-         _psvbb = new ParameterStartValuesBuildingBlock();
-         _psv1 = new ParameterStartValue{Path = new ObjectPath("A")};
-         _project = A.Fake<IMoBiProject>();
-
-         _psv2 = new ParameterStartValue { Path = new ObjectPath("B") };
-         _psv3 = new ParameterStartValue { Path = new ObjectPath(Constants.Distribution.GEOMETRIC_DEVIATION) };
-         _psvbb.Add(_psv1);
-         _psvbb.Add(_psv2);
-         _psvbb.Add(_psv3);
-         _startValue = 2;
-         _psv3.StartValue = _startValue;
-         _dim = A.Fake<IDimension>();
-         A.CallTo(_dimensionRetriever).WithReturnType<IDimension>().Returns(_dim);
-      }
-
-      protected override void Because()
-      {
-         sut.UpdateParameterStartvalues(_psvbb, _project);
-      }
-
-      [Observation]
-      public void should_ask_dimesnion_retirever_for_the_dimesion_of_each_parameter_start_value()
-      {
-         A.CallTo(() => _dimensionRetriever.GetDimensionFor(_psv1, _psvbb, _project)).MustHaveHappened();
-         A.CallTo(() => _dimensionRetriever.GetDimensionFor(_psv2, _psvbb, _project)).MustHaveHappened();
-         A.CallTo(() => _dimensionRetriever.GetDimensionFor(_psv3, _psvbb, _project)).MustHaveHappened();
-      }
-
-      [Observation]
-      public void should_set_dimension_for_all_parameter_start_values()
-      {
-         _psv1.Dimension.ShouldBeEqualTo(_dim);
-         _psv2.Dimension.ShouldBeEqualTo(_dim);
-         _psv3.Dimension.ShouldBeEqualTo(_dim);
-      }
-
-      [Observation]
-      public void should_change_value_of_psv_3()
-      {
-         _psv3.StartValue.ShouldBeEqualTo(Math.Exp(_startValue));
-      }
-   }
-}
\ No newline at end of file
diff --git a/tests/MoBi.Tests/ProjectConversion/v3_1/ParameterStartValueDimensionRetrieverSpecs.cs b/tests/MoBi.Tests/ProjectConversion/v3_1/ParameterStartValueDimensionRetrieverSpecs.cs
deleted file mode 100644
index fe1aabbad..000000000
--- a/tests/MoBi.Tests/ProjectConversion/v3_1/ParameterStartValueDimensionRetrieverSpecs.cs
+++ /dev/null
@@ -1,77 +0,0 @@
-using FakeItEasy;
-using MoBi.Core.Domain.Model;
-using MoBi.Core.Serialization.Converter.v3_1;
-using OSPSuite.BDDHelper;
-using OSPSuite.BDDHelper.Extensions;
-using OSPSuite.Core.Domain;
-using OSPSuite.Core.Domain.Builder;
-using OSPSuite.Core.Domain.UnitSystem;
-
-namespace MoBi.ProjectConversion.v3_1
-{
-   public abstract class concern_for_ParameterStartValueDimensionRetriever : ContextSpecification<IParameterStartValueDimensionRetriever>
-   {
-      protected IMoBiContext _context;
-
-      protected override void Context()
-      {
-         _context = A.Fake<IMoBiContext>();
-         sut = new ParameterStartValueDimensionRetriever();
-      }
-   }
-
-   internal class When_retieving_a_dimension_for_a_paramter_start_value : concern_for_ParameterStartValueDimensionRetriever
-   {
-      private IParameterStartValuesBuildingBlock _parentBuidlidingBlock;
-      private IParameterStartValue _startValue;
-      private IMoBiProject _project;
-      private IMoBiBuildConfiguration _buildConfiguration;
-      private IObjectPath _parameterPath;
-      private IContainer _root;
-      private IDimension _reultDimension;
-      private IParameter _para;
-      private IMoBiSimulation _simulation;
-      private IModel _model;
-
-      protected override void Context()
-      {
-         base.Context();
-         _project = A.Fake<IMoBiProject>();
-         _startValue = A.Fake<IParameterStartValue>();
-         _parameterPath = A.Fake<IObjectPath>();
-         _parentBuidlidingBlock = A.Fake<IParameterStartValuesBuildingBlock>();
-         _parentBuidlidingBlock.Id = "Parent";
-         _para = A.Fake<IParameter>().WithName("Para").WithDimension(A.Fake<IDimension>());
-         A.CallTo(() => _startValue.Path).Returns(_parameterPath);
-         _simulation = A.Fake<IMoBiSimulation>();
-         A.CallTo(() => _project.Simulations).Returns(new[] {_simulation,});
-         _buildConfiguration = A.Fake<IMoBiBuildConfiguration>();
-         _buildConfiguration.ParameterStartValuesInfo = new ParameterStartValuesBuildingBlockInfo();
-         _buildConfiguration.ParameterStartValuesInfo.TemplateBuildingBlock = _parentBuidlidingBlock;
-         _model = A.Fake<IModel>();
-         _root = A.Fake<IContainer>();
-         A.CallTo(() => _simulation.MoBiBuildConfiguration).Returns(_buildConfiguration);
-         A.CallTo(() => _simulation.Model).Returns(_model);
-         A.CallTo(() => _parameterPath.Resolve<IParameter>(_root)).Returns(_para);
-         _model.Root = _root;
-         A.CallTo(() => _context.CurrentProject).Returns(_project);
-      }
-
-      protected override void Because()
-      {
-         _reultDimension = sut.GetDimensionFor(_startValue, _parentBuidlidingBlock, _project);
-      }
-
-      [Observation]
-      public void should_retrieve_parameter_in_simulation()
-      {
-         A.CallTo(() => _parameterPath.Resolve<IParameter>(_root)).MustHaveHappened();
-      }
-
-      [Observation]
-      public void should_return_the_parameters_dimension()
-      {
-         _reultDimension.ShouldBeEqualTo(_para.Dimension);
-      }
-   }
-}
\ No newline at end of file
diff --git a/tests/MoBi.Tests/ProjectConversion/v3_1/ProjectUpdaterSpecs.cs b/tests/MoBi.Tests/ProjectConversion/v3_1/ProjectUpdaterSpecs.cs
deleted file mode 100644
index 5f282702b..000000000
--- a/tests/MoBi.Tests/ProjectConversion/v3_1/ProjectUpdaterSpecs.cs
+++ /dev/null
@@ -1 +0,0 @@
-
\ No newline at end of file
diff --git a/tests/MoBi.Tests/ProjectConversion/v3_1/SpatialStructureUpdaterSpecs.cs b/tests/MoBi.Tests/ProjectConversion/v3_1/SpatialStructureUpdaterSpecs.cs
deleted file mode 100644
index fede8bed5..000000000
--- a/tests/MoBi.Tests/ProjectConversion/v3_1/SpatialStructureUpdaterSpecs.cs
+++ /dev/null
@@ -1,46 +0,0 @@
-using System;
-using MoBi.Core.Serialization.Converter.v3_1;
-using OSPSuite.BDDHelper;
-using OSPSuite.BDDHelper.Extensions;
-using OSPSuite.Core.Domain;
-using OSPSuite.Core.Domain.Formulas;
-
-namespace MoBi.ProjectConversion.v3_1
-{
-   public abstract class concern_for_SpatialStructureUpdaterSpecs : ContextSpecification<ISpatialStructureUpdaterTo3_1_3>
-   {
-      protected override void Context()
-      {
-         sut = new SpatialStructureUpdaterTo3_1_3();
-      }
-   }
-
-   class When_updating_a_distributed_parameter_with_a_Log_normal_distribution : concern_for_SpatialStructureUpdaterSpecs
-   {
-      private IDistributedParameter _distributedParameter;
-      private double _geometricDeviation = 1;
-      private Parameter _geoSDParameter;
-
-      protected override void Context()
-      {
-         base.Context();
-         _distributedParameter = new DistributedParameter().WithName("DP").WithFormula(new LogNormalDistributionFormula());
-         _distributedParameter.Add(
-            new Parameter().WithName(Constants.Distribution.MEAN).WithFormula(new ConstantFormula().WithValue(2)));
-         _geoSDParameter = new Parameter().WithName(Constants.Distribution.GEOMETRIC_DEVIATION).WithFormula(new ConstantFormula().WithValue(_geometricDeviation));
-         _distributedParameter.Add(_geoSDParameter);
-
-      }
-
-      protected override void Because()
-      {
-         sut.UpdateDistributedParameterTo3_1_3(_distributedParameter);
-      }
-
-      [Observation]
-      public void should_change_Geometric_Deviation_to_its_exp_value()
-      {
-         _geoSDParameter.Value.ShouldBeEqualTo(Math.Exp(_geometricDeviation));
-      }
-   }
-}	
\ No newline at end of file
diff --git a/tests/MoBi.Tests/ProjectConversion/v3_2/EventGroupBuildingBlockConversionSpecs.cs b/tests/MoBi.Tests/ProjectConversion/v3_2/EventGroupBuildingBlockConversionSpecs.cs
deleted file mode 100644
index 45b241bc1..000000000
--- a/tests/MoBi.Tests/ProjectConversion/v3_2/EventGroupBuildingBlockConversionSpecs.cs
+++ /dev/null
@@ -1,35 +0,0 @@
-using System.Linq;
-using OSPSuite.BDDHelper;
-using OSPSuite.BDDHelper.Extensions;
-using MoBi.Core;
-using MoBi.IntegrationTests;
-using OSPSuite.Core.Domain.Builder;
-
-namespace MoBi.ProjectConversion.v3_2
-{
-   public abstract class concern_for_EventGroupBuildingBlockConversionSpecs : ContextWithLoadedProject
-   {
-      protected IEventGroupBuildingBlock _eventGroupBuildingBlock;
-
-      public override void GlobalContext()
-      {
-         base.GlobalContext();
-         _eventGroupBuildingBlock = LoadPKML<IEventGroupBuildingBlock>("Events");
-      }
-   }
-
-   public class When_converting_an_event_group_building_block : concern_for_EventGroupBuildingBlockConversionSpecs
-   {
-      [Observation]
-      public void should_move_event_assigments_to_children()
-      {
-         var eventGroup = _eventGroupBuildingBlock.First();
-         var applicationBuilder = eventGroup.GetAllChildren<IApplicationBuilder>().First();
-         eventGroup.ShouldNotBeNull();
-         applicationBuilder.GetChildren<ITransportBuilder>().Count().ShouldBeEqualTo(1);
-         applicationBuilder.GetChildren<IApplicationMoleculeBuilder>().Count().ShouldBeEqualTo(1);
-         var domainEvent = eventGroup.GetAllChildren<IEventBuilder>().First();
-         domainEvent.GetChildren<IEventAssignmentBuilder>().Count().ShouldBeEqualTo(1);
-      }
-   }
-}
\ No newline at end of file
diff --git a/tests/MoBi.Tests/ProjectConversion/v3_2/MoleculeBuildingBlockConversionSpecs.cs b/tests/MoBi.Tests/ProjectConversion/v3_2/MoleculeBuildingBlockConversionSpecs.cs
deleted file mode 100644
index 3b6c59e79..000000000
--- a/tests/MoBi.Tests/ProjectConversion/v3_2/MoleculeBuildingBlockConversionSpecs.cs
+++ /dev/null
@@ -1,43 +0,0 @@
-using System.Linq;
-using OSPSuite.BDDHelper;
-using OSPSuite.BDDHelper.Extensions;
-using MoBi.IntegrationTests;
-using OSPSuite.Core.Domain;
-using OSPSuite.Core.Domain.Builder;
-
-namespace MoBi.ProjectConversion.v3_2
-{
-   public abstract class concern_for_MoleculeBuildingBlockConversionSpecs : ContextWithLoadedProject
-   {
-      protected IMoleculeBuildingBlock _moleculeBuildingBlock;
-
-      public override void GlobalContext()
-      {
-         base.GlobalContext();
-         _moleculeBuildingBlock = LoadPKML<IMoleculeBuildingBlock>("Molecules");
-      }
-   }
-
-   internal class When_converting_a_molecule_building_block : concern_for_MoleculeBuildingBlockConversionSpecs
-   {
-      [Observation]
-      public void should_move_parameters_and_transport_realizations_of_Transporter_container_to_children()
-      {
-         var transporterContainer = _moleculeBuildingBlock.First().GetChildren<IContainer>().First();
-         var parameter = transporterContainer.GetChildren<IParameter>();
-         parameter.Count().ShouldBeEqualTo(1);
-         var transporter = transporterContainer.GetChildren<ITransportBuilder>();
-         transporter.Count().ShouldBeEqualTo(1);
-         var transport = transporter.First();
-         transport.Children.Count().ShouldBeEqualTo(1);
-      }
-
-      [Observation]
-      public void should_not_move_passive_transports_to_molecule_children()
-      {
-         var moleculeBuilder = _moleculeBuildingBlock.First();
-         var transporter = moleculeBuilder.GetChildren<ITransportBuilder>();
-         transporter.Any().ShouldBeFalse();
-      }
-   }
-}
\ No newline at end of file
diff --git a/tests/MoBi.Tests/ProjectConversion/v3_2/MultipleOutputSchemaItemConversionSpecs.cs b/tests/MoBi.Tests/ProjectConversion/v3_2/MultipleOutputSchemaItemConversionSpecs.cs
deleted file mode 100644
index 104f97061..000000000
--- a/tests/MoBi.Tests/ProjectConversion/v3_2/MultipleOutputSchemaItemConversionSpecs.cs
+++ /dev/null
@@ -1,31 +0,0 @@
-using System.Collections.Generic;
-using System.Linq;
-using OSPSuite.BDDHelper;
-using OSPSuite.BDDHelper.Extensions;
-using MoBi.IntegrationTests;
-using OSPSuite.Core.Domain;
-
-namespace MoBi.ProjectConversion.v3_2
-{
-   public abstract class concern_for_MultipleOutputSchemaItemConversion : ContextWithLoadedProject
-   {
-      protected IModelCoreSimulation _simulation;
-      protected List<OutputInterval> _intervals;
-
-      public override void GlobalContext()
-      {
-         base.GlobalContext();
-         _simulation = LoadProject("ManualModel_Sim").Simulations.First();
-      }
-   }
-
-   public class When_converting_the_output_schema_in_the_project_containing_multiple_intervals : concern_for_MultipleOutputSchemaItemConversion
-   {
-      [Observation]
-      public void should_have_converted_the_existing_intervals()
-      {
-         _intervals = _simulation.BuildConfiguration.SimulationSettings.OutputSchema.Intervals.ToList();
-         _intervals.Count.ShouldBeEqualTo(2);
-      }
-   }
-}
\ No newline at end of file
diff --git a/tests/MoBi.Tests/ProjectConversion/v3_2/OutputSchemaConversionSpecs.cs b/tests/MoBi.Tests/ProjectConversion/v3_2/OutputSchemaConversionSpecs.cs
deleted file mode 100644
index 61068166a..000000000
--- a/tests/MoBi.Tests/ProjectConversion/v3_2/OutputSchemaConversionSpecs.cs
+++ /dev/null
@@ -1,37 +0,0 @@
-using System.Collections.Generic;
-using System.Linq;
-using OSPSuite.BDDHelper;
-using OSPSuite.BDDHelper.Extensions;
-using MoBi.Core;
-using MoBi.IntegrationTests;
-using OSPSuite.Core.Domain;
-using OSPSuite.Core.Serialization.Exchange;
-
-namespace MoBi.ProjectConversion.v3_2
-{
-   public abstract class concern_for_OutputSchemaConversion : ContextWithLoadedProject
-   {
-      protected IModelCoreSimulation _simulation;
-      protected List<OutputInterval> _intervals;
-
-      public override void GlobalContext()
-      {
-         base.GlobalContext();
-         _simulation = LoadPKML<SimulationTransfer>("warnings").Simulation;
-      }
-   }
-
-   public class When_converting_the_output_schema_in_the_project_warning : concern_for_OutputSchemaConversion
-   {
-      [Observation]
-      public void should_have_converted_the_existing_intervals()
-      {
-         _intervals = _simulation.BuildConfiguration.SimulationSettings.OutputSchema.Intervals.ToList();
-         _intervals.Count.ShouldBeEqualTo(1);
-         var interval = _intervals[0];
-         interval.GetSingleChildByName<IParameter>(Constants.Parameters.START_TIME).Value.ShouldBeEqualTo(0);
-         interval.GetSingleChildByName<IParameter>(Constants.Parameters.END_TIME).Value.ShouldBeEqualTo(1440);
-         interval.GetSingleChildByName<IParameter>(Constants.Parameters.RESOLUTION).Value.ShouldBeEqualTo(4.0 / 60.0);
-      }
-   }
-}
\ No newline at end of file
diff --git a/tests/MoBi.Tests/ProjectConversion/v3_2/PK_Manual_DiclofenacSpecs.cs b/tests/MoBi.Tests/ProjectConversion/v3_2/PK_Manual_DiclofenacSpecs.cs
deleted file mode 100644
index 3eb69cc5a..000000000
--- a/tests/MoBi.Tests/ProjectConversion/v3_2/PK_Manual_DiclofenacSpecs.cs
+++ /dev/null
@@ -1,160 +0,0 @@
-using System.Collections.Generic;
-using System.Linq;
-using OSPSuite.BDDHelper;
-using OSPSuite.BDDHelper.Extensions;
-using OSPSuite.Utility.Container;
-using OSPSuite.Utility.Extensions;
-using MoBi.Core.Domain.Model;
-using MoBi.IntegrationTests;
-using OSPSuite.Core.Domain;
-using OSPSuite.Core.Domain.Builder;
-using OSPSuite.Core.Domain.Services;
-
-namespace MoBi.ProjectConversion.v3_2
-{
-   public abstract class PK_Manual_DiclofenacSpecs : ContextWithLoadedProject
-   {
-      protected IMoBiProject _project;
-
-      public override void GlobalContext()
-      {
-         base.GlobalContext();
-         _project = LoadProject("PK_Manual_Diclofenac");
-      }
-   }
-
-   internal class When_converting_old_Dicolfenac_example : PK_Manual_DiclofenacSpecs
-   {
-      [Observation]
-      public void should_set_project_Has_Changed_flag_to_false()
-      {
-         //project does not need to be saved necessarily. It was just open
-         _project.HasChanged.ShouldBeFalse();
-      }
-
-      [Observation]
-      public void should_set_all_simulations_to_changed()
-      {
-         _project.Simulations.Each(sim => sim.HasChanged.ShouldBeTrue());
-      }
-   }
-
-   internal class When_recreating_existing_simulation : PK_Manual_DiclofenacSpecs
-   {
-      private IMoBiSimulation _simulation;
-      private IModelConstructor _modelConstructor;
-      private IMoBiBuildConfiguration _buildConfiguration;
-      private CreationResult _results;
-      private ISimModelManager _simModelManager;
-      private IMoBiContext _context;
-
-      protected override void Context()
-      {
-         base.Context();
-         _modelConstructor = IoC.Resolve<IModelConstructor>();
-         _simModelManager = IoC.Resolve<ISimModelManager>();
-         _buildConfiguration = IoC.Resolve<IBuildConfigurationFactory>().CreateFromReferencesUsedIn(_project.Simulations.Last().MoBiBuildConfiguration);
-         _buildConfiguration.ShowProgress = false;
-         _context = IoC.Resolve<IMoBiContext>();
-      }
-
-      protected override void Because()
-      {
-         _results = _modelConstructor.CreateModelFrom(_buildConfiguration, "test");
-      }
-
-      [Observation]
-      public void should_be_able_to_create_simulation()
-      {
-         _results.State.ShouldNotBeEqualTo(ValidationState.Invalid, _results.ValidationResult.Messages.SelectMany(x => x.Details).ToString("\n"));
-         _simulation = new MoBiSimulation {BuildConfiguration = _buildConfiguration, Model = _results.Model};
-         _simulation.Id = "Sim";
-         _context.Register(_simulation);
-         _simModelManager.RunSimulation(_simulation);
-      }
-   }
-
-   internal class When_creating_and_running_a_new_simulation : PK_Manual_DiclofenacSpecs
-   {
-      private IMoBiSimulation _simulation;
-      private IModelConstructor _modelConstructor;
-      private IMoBiBuildConfiguration _buildConfiguration;
-      private CreationResult _results;
-      private ISimModelManager _simModelManager;
-      private IMoBiContext _context;
-      private ICoreCalculationMethodRepository _calculationMethodRepository;
-
-      protected override void Context()
-      {
-         base.Context();
-         _modelConstructor = IoC.Resolve<IModelConstructor>();
-         _simModelManager = IoC.Resolve<ISimModelManager>();
-         _context = IoC.Resolve<IMoBiContext>();
-         _calculationMethodRepository = IoC.Resolve<ICoreCalculationMethodRepository>();
-         _buildConfiguration = createBuildConfiguration();
-      }
-
-      private IMoBiBuildConfiguration createBuildConfiguration()
-      {
-         var moBiBuildConfiguration = new MoBiBuildConfiguration()
-         {
-            SpatialStructure = _project.SpatialStructureCollection.First(),
-            Molecules = _project.MoleculeBlockCollection.First(),
-            Reactions = _project.ReactionBlockCollection.First(),
-            PassiveTransports = _project.PassiveTransportCollection.First(),
-            Observers = _project.ObserverBlockCollection.First(),
-            EventGroups = _project.EventBlockCollection.First(),
-            MoleculeStartValues = _project.MoleculeStartValueBlockCollection.First(),
-            ParameterStartValues = _project.ParametersStartValueBlockCollection.First(),
-            SimulationSettings = _project.SimulationSettingsCollection.First()
-         };
-         _calculationMethodRepository.All().Each(moBiBuildConfiguration.AddCalculationMethod);
-         moBiBuildConfiguration.ShowProgress = false;
-         moBiBuildConfiguration.ShouldValidate = true;
-         return moBiBuildConfiguration;
-      }
-
-      protected override void Because()
-      {
-         _results = _modelConstructor.CreateModelFrom(_buildConfiguration, "test");
-      }
-
-      [Observation]
-      public void should_be_able_to_create_simulation()
-      {
-         _results.State.ShouldNotBeEqualTo(ValidationState.Invalid, _results.ValidationResult.Messages.SelectMany(x => x.Details).ToString("\n"));
-         _simulation = new MoBiSimulation {BuildConfiguration = _buildConfiguration, Model = _results.Model};
-         _simulation.Id = "Sim";
-         _context.Register(_simulation);
-         _simModelManager.RunSimulation(_simulation);
-      }
-   }
-
-   internal class When_converting_the_molecule_building_block_ : PK_Manual_DiclofenacSpecs
-   {
-      private IMoleculeBuildingBlock _moleculeBuildingBlock;
-
-      [Observation]
-      public void should_have_converted_the_molecule_building_block()
-      {
-         _moleculeBuildingBlock = _project.MoleculeBlockCollection.First();
-         _moleculeBuildingBlock.ShouldNotBeNull();
-      }
-   }
-
-   public class When_converting_the_output_schema_in_the_project_PK_Manual_Diclofenac : PK_Manual_DiclofenacSpecs
-   {
-      private List<OutputInterval> _intervals;
-
-      [Observation]
-      public void should_have_converted_the_existing_intervals()
-      {
-         _intervals = _project.Simulations.First().Settings.OutputSchema.Intervals.ToList();
-         _intervals.Count.ShouldBeEqualTo(1);
-         var interval = _intervals[0];
-         interval.GetSingleChildByName<IParameter>(Constants.Parameters.START_TIME).Value.ShouldBeEqualTo(0);
-         interval.GetSingleChildByName<IParameter>(Constants.Parameters.END_TIME).Value.ShouldBeEqualTo(1440);
-         interval.GetSingleChildByName<IParameter>(Constants.Parameters.RESOLUTION).Value.ShouldBeEqualTo(4.0 / 60.0, 0.00000001);
-      }
-   }
-}
\ No newline at end of file
diff --git a/tests/MoBi.Tests/ProjectConversion/v3_2/PassiveTransportBuildingBlockConversionSpecs.cs b/tests/MoBi.Tests/ProjectConversion/v3_2/PassiveTransportBuildingBlockConversionSpecs.cs
deleted file mode 100644
index 8498112c5..000000000
--- a/tests/MoBi.Tests/ProjectConversion/v3_2/PassiveTransportBuildingBlockConversionSpecs.cs
+++ /dev/null
@@ -1,32 +0,0 @@
-using System.Linq;
-using OSPSuite.BDDHelper;
-using OSPSuite.BDDHelper.Extensions;
-using MoBi.Core;
-using MoBi.IntegrationTests;
-using OSPSuite.Core.Domain;
-using OSPSuite.Core.Domain.Builder;
-
-namespace MoBi.ProjectConversion.v3_2
-{
-   public abstract class concern_for_PassiveTransportBuildingBlockConversionSpecs : ContextWithLoadedProject
-   {
-      protected IPassiveTransportBuildingBlock _passiveTransportBuildingBlock;
-
-      public override void GlobalContext()
-      {
-         base.GlobalContext();
-         _passiveTransportBuildingBlock = LoadPKML<IPassiveTransportBuildingBlock>("Passive Transports");
-      }
-   }
-
-   internal class When_converting_a_passive_transport_building_block : concern_for_PassiveTransportBuildingBlockConversionSpecs
-   {
-      [Observation]
-      public void should_return_parameter_as_children()
-      {
-         var passiveTransport = _passiveTransportBuildingBlock.First();
-         passiveTransport.GetChildren<IParameter>().Count().ShouldBeEqualTo(1);
-         passiveTransport.Parameters.First().BuildMode.ShouldBeEqualTo(ParameterBuildMode.Local);
-      }
-   }
-}
\ No newline at end of file
diff --git a/tests/MoBi.Tests/ProjectConversion/v3_3/ChartConversionSpecs.cs b/tests/MoBi.Tests/ProjectConversion/v3_3/ChartConversionSpecs.cs
deleted file mode 100644
index 65fc89ba5..000000000
--- a/tests/MoBi.Tests/ProjectConversion/v3_3/ChartConversionSpecs.cs
+++ /dev/null
@@ -1,27 +0,0 @@
-using OSPSuite.BDDHelper;
-using OSPSuite.BDDHelper.Extensions;
-using MoBi.IntegrationTests;
-using OSPSuite.Core.Chart;
-
-namespace MoBi.ProjectConversion.v3_3
-{
-   public abstract class concern_for_ChartConversion : ContextWithLoadedProject
-   {
-      protected CurveChart _chart;
-
-      public override void GlobalContext()
-      {
-         base.GlobalContext();
-         _chart = LoadPKML<CurveChart>("Chart");
-      }
-   }
-
-   internal class When_converting_ab_chart_element : concern_for_ChartConversion
-   {
-      [Observation]
-      public void should_have_loaded_the_chart()
-      {
-         _chart.ShouldNotBeNull();
-      }
-   }
-}
\ No newline at end of file
diff --git a/tests/MoBi.Tests/ProjectConversion/v3_3/Converter32To33Specs.cs b/tests/MoBi.Tests/ProjectConversion/v3_3/Converter32To33Specs.cs
deleted file mode 100644
index 31fbbaeaf..000000000
--- a/tests/MoBi.Tests/ProjectConversion/v3_3/Converter32To33Specs.cs
+++ /dev/null
@@ -1,267 +0,0 @@
-using System.Collections;
-using System.Linq;
-using OSPSuite.Utility.Events;
-using FakeItEasy;
-
-using OSPSuite.BDDHelper;
-using OSPSuite.BDDHelper.Extensions;
-using MoBi.Core.Domain.Model;
-using MoBi.Core.Domain.UnitSystem;
-using MoBi.Core.Helper;
-using MoBi.Core.Serialization.Converter;
-using MoBi.Core.Serialization.Converter.v3_3;
-
-using OSPSuite.Core.Domain;
-using OSPSuite.Core.Domain.Builder;
-using OSPSuite.Core.Domain.Formulas;
-using OSPSuite.Core.Domain.Services;
-using OSPSuite.Core.Domain.UnitSystem;
-
-
-namespace MoBi.ProjectConversion.v3_3
-{
-   public abstract class concern_for_Converter32To33Specs : ContextSpecification<IMoBiObjectConverter>
-   {
-      private IMoBiContext _context;
-      
-      private IDimension _noDimension;
-      private IFormulaTask _formulaTask;
-
-      protected override void Context()
-      {
-         _context = A.Fake<IMoBiContext>();
-         var dimensionFactory = A.Fake<IMoBiDimensionFactory>();
-         A.CallTo(() => _context.DimensionFactory).Returns(dimensionFactory);
-         A.CallTo(() => dimensionFactory.NoDimension).Returns(_noDimension);
-         _noDimension = A.Fake<IDimension>();
-         _formulaTask = A.Fake<IFormulaTask>();
-         sut = new Converter321To331(_context,_formulaTask);
-      }
-   }
-
-   class When_converting_an_molecule_buidding_block : concern_for_Converter32To33Specs
-   {
-      private IMoleculeBuildingBlock _moleculeBuildingBlock;
-
-      protected override void Context()
-      {
-         base.Context();
-         _moleculeBuildingBlock = new MoleculeBuildingBlock();
-         _moleculeBuildingBlock.Add(new MoleculeBuilder().WithName("Drug"));
-         _moleculeBuildingBlock.Add(new MoleculeBuilder().WithName("Transporter"));
-      }
-
-      protected override void Because()
-      {
-         sut.Convert(_moleculeBuildingBlock, A.Fake<IMoBiProject>());
-      }
-
-      [Observation]
-      public void should_add_total_drug_mass_parameter_to_all_molecule_builders()
-      {
-         foreach (var moleculeBuilder in _moleculeBuildingBlock)
-         {
-            var parameter = moleculeBuilder.GetSingleChildByName<IParameter>("Total drug mass");
-            parameter.ShouldNotBeNull();
-            parameter.BuildMode.ShouldBeEqualTo(ParameterBuildMode.Property);
-            parameter.Formula.ShouldBeAnInstanceOf<SumFormula>();
-         }
-      }
-   }
-
-   class When_converting_observer_building_block : concern_for_Converter32To33Specs
-   {
-      private IFormulaUsablePath _totalDrugMassReference;
-      private IObserverBuildingBlock _observerBuildingBlock;
-
-      protected override void Context()
-      {
-         base.Context();
-         var monitor = new ExplicitFormula("TotalDrugMass");
-         var observer = new ContainerObserverBuilder().WithName("Tralala").WithFormula(monitor);
-         _totalDrugMassReference = new FormulaUsablePath(new[] { "Applications", "TotalDrugMass" }).WithAlias("TotalDrugMass");
-         monitor.AddObjectPath(_totalDrugMassReference);
-         _observerBuildingBlock = new ObserverBuildingBlock();
-         _observerBuildingBlock.Add(observer);
-      }
-
-      protected override void Because()
-      {
-         sut.Convert(_observerBuildingBlock, A.Fake<IMoBiProject>());
-      }
-
-      [Observation]
-      public void should_have_canged_total_drug_mass_parameter_reference()
-      {
-         _totalDrugMassReference.ShouldOnlyContainInOrder(ObjectPathKeywords.MOLECULE,"Total drug mass");
-      }
-
-   }
-
-   class When_converting_an_event_group : concern_for_Converter32To33Specs
-   {
-      private IEventGroupBuildingBlock _eventGroupBuildingBlock;
-      private IParameter _drugMassParameter;
-      private IEventGroupBuilder applications;
-
-      protected override void Context()
-      {
-         base.Context();
-         _eventGroupBuildingBlock = new EventGroupBuildingBlock();
-         var eventGroup = new EventGroupBuilder().WithName("EG");
-         _eventGroupBuildingBlock.Add(eventGroup);
-         var ehcStartEvent = new EventBuilder().WithName(Converter321To331.EHCStartEvent);
-         eventGroup.Add(ehcStartEvent);
-         var eabOldStart = new EventAssignmentBuilder().WithName("EAB1").WithFormula(new ExplicitFormula("ln(2) / EHC_Halftime * M * EHC_EjectionFraction"));
-         eabOldStart.UseAsValue = false;
-         eabOldStart.ObjectPath = new ObjectPath(new[] { "Organism", "Gallbladder", "Gallbladder emptying rate" });
-         ehcStartEvent.AddAssignment(eabOldStart);
-         var assignmentBuilder = new EventAssignmentBuilder().WithName("EAB2").WithFormula(new ExplicitFormula("DontChange"));
-         assignmentBuilder.ObjectPath = new ObjectPath( new[]{"PATH"});
-         ehcStartEvent.AddAssignment(assignmentBuilder);
-         var ehcStopEvent = new EventBuilder().WithName(Converter321To331.EHCStopEvent);
-         var eabOldStop = new EventAssignmentBuilder().WithName("EAB1").WithFormula(new ConstantFormula(0));
-         eabOldStop.UseAsValue = false;
-         eabOldStop.ObjectPath = new ObjectPath(new[] { "Organism", "Gallbladder", "Gallbladder emptying rate" });
-         ehcStopEvent.AddAssignment(eabOldStop);
-         assignmentBuilder = new EventAssignmentBuilder().WithName("EAB2").WithFormula(new ExplicitFormula("DontChange"));
-         assignmentBuilder.ObjectPath = new ObjectPath(new[] { "PATH" });
-         ehcStopEvent.AddAssignment(assignmentBuilder);
-         eventGroup.Add(ehcStopEvent);
-
-         var protocolSchemaItem = new Container().WithName("ProtocolSchemaItem").WithParentContainer(eventGroup);
-         _drugMassParameter = new Parameter().WithName("DrugMass").WithParentContainer(protocolSchemaItem).WithValue(1);
-
-         applications = new EventGroupBuilder().WithName("Applications");
-         applications.Add(new Parameter().WithName("TotalDrugMass"));
-         _eventGroupBuildingBlock.Add(applications);
-      }
-
-      protected override void Because()
-      {
-         sut.Convert(_eventGroupBuildingBlock, A.Fake<IMoBiProject>());
-      }
-
-      [Observation]
-      public void should_change_EHC_Start_event_to_assign_Gallbladder_emptying_active()
-      {
-         var eventGroup = _eventGroupBuildingBlock.First();
-         var ehcStartEvent = eventGroup.GetSingleChildByName<IEventBuilder>(Converter321To331.EHCStartEvent);         
-         var assingment = ehcStartEvent.Assignments.FirstOrDefault(a => a.ObjectPath.PathAsString.Equals("Organism|Gallbladder|Gallbladder emptying active"));
-         assingment.ShouldNotBeNull();
-         assingment.UseAsValue.ShouldBeFalse();
-         assingment.Formula.IsConstant().ShouldBeTrue();
-         ((ConstantFormula)assingment.Formula).Value.ShouldBeEqualTo(1);
-      }
-
-      [Observation]
-      public void should_change_EHC_Stop_event_to_assign_Gallbladder_emptying_active()
-      {
-         var eventGroup = _eventGroupBuildingBlock.First();
-         var ehcStopEvent= eventGroup.GetSingleChildByName<IEventBuilder>(Converter321To331.EHCStopEvent);
-         var assingment = ehcStopEvent.Assignments.FirstOrDefault(a => a.ObjectPath.PathAsString.Equals("Organism|Gallbladder|Gallbladder emptying active"));
-         assingment.ShouldNotBeNull();
-         assingment.UseAsValue.ShouldBeTrue();
-         assingment.Formula.IsConstant().ShouldBeTrue();
-         ((ConstantFormula)assingment.Formula).Value.ShouldBeEqualTo(0);
-      }
-
-      [Observation]
-      public void should_leave_other_assignments_unchanged()
-      {
-         var eventGroup = _eventGroupBuildingBlock.First();
-         eventGroup.GetSingleChildByName<IEventBuilder>(Converter321To331.EHCStartEvent);
-         foreach (var eventBuilder in eventGroup.GetChildren<IEventBuilder>())
-         {
-            var assingment = eventBuilder.Assignments.FindByName("EAB2");
-            assingment.Formula.IsExplicit().ShouldBeTrue();
-            ((ExplicitFormula)assingment.Formula).FormulaString.ShouldBeEqualTo("DontChange");
-            assingment.ObjectPath.PathAsString.ShouldBeEqualTo("PATH");
-         }
-      }
-
-      [Observation]
-      public void should_add_molecule_tag_to_drugmass_Parameter()
-      {
-         var moleculeTag = _drugMassParameter.Tags.FirstOrDefault(t => t.Value.Equals(ObjectPathKeywords.MOLECULE));
-         moleculeTag.ShouldNotBeNull();
-      }
-
-      [Observation]
-      public void should_have_removed_total_drug_mass()
-      {
-         applications.ContainsName("TotalDrugMass").ShouldBeFalse();
-      }
-   }
-
-   class When_converting_an_spatial_Structure : concern_for_Converter32To33Specs
-   {
-      private ISpatialStructure _spatialStructure;
-      private Parameter _param;
-
-      protected override void Context()
-      {
-         base.Context();
-         _spatialStructure = new SpatialStructure();
-         var organism = new Container().WithName(Constants.ORGANISM);
-         _spatialStructure.AddTopContainer(organism);
-         var gallbladder = new Container().WithName(Converter321To331.Gallbladder).WithParentContainer(organism);
-         _param = new Parameter().WithName("Volume").WithParentContainer(gallbladder);
-         _spatialStructure.GlobalMoleculeDependentProperties = new Container();
-         _spatialStructure.NeighborhoodsContainer = new Container();
-      }
-
-      protected override void Because()
-      {
-         sut.Convert(_spatialStructure, A.Fake<IMoBiProject>());
-      }
-
-      [Observation]
-      public void should_have_added_gallbladderemptying_active_parameter()
-      {
-         var organism = _spatialStructure.TopContainers.First(c => c.Name.Equals(Constants.ORGANISM));
-         var gallbladder = organism.GetSingleChildByName<IContainer>(Converter321To331.Gallbladder);
-         var parameter = gallbladder.GetSingleChildByName<IParameter>(Converter321To331.GallbladderEmptyingActive);
-         parameter.ShouldNotBeNull();
-         parameter.Formula.IsExplicit();
-      }
-
-      [Observation]
-      public void should_set_group_of_param_to_mobi()
-      {
-         _param.GroupName.ShouldBeEqualTo(Constants.Groups.MOBI);
-      }
-
-   }
-
-   class When_converting_an_GallBladderEmptyingTransportBuilder : concern_for_Converter32To33Specs
-   {
-      private ITransportBuilder _transportBuilder;
-      private IMoBiProject _project;
-      private ExplicitFormula _kinetic;
-      private IPassiveTransportBuildingBlock _buildingBlock;
-
-      protected override void Context()
-      {
-         base.Context();
-         _project= A.Fake<IMoBiProject>();
-         _kinetic = new ExplicitFormula("GallbladderEmptyingRate");
-         _transportBuilder = new TransportBuilder().WithName("GallbladderEmptying").WithKinetic(_kinetic);
-         _buildingBlock  = new PassiveTransportBuildingBlock();
-         _buildingBlock.Add(_transportBuilder);
-      }
-
-      protected override void Because()
-      {
-         sut.Convert(_buildingBlock, _project);
-      }
-
-      [Observation]
-      public void should_change_the_kinetic_to_new_rate()
-      {
-         _kinetic.FormulaString.ShouldBeEqualTo("EHC_Active ? ln(2) / EHC_Halftime * M * EHC_EjectionFraction : 0");
-         var alias = _kinetic.ObjectPaths.Select(op => op.Alias);
-         alias.ShouldOnlyContain("EHC_Active", "EHC_Halftime","M","EHC_EjectionFraction");
-      }
-   }
-}	
\ No newline at end of file
diff --git a/tests/MoBi.Tests/ProjectConversion/v3_3/PassiveTransportBuildignBlockConversionSpecs.cs b/tests/MoBi.Tests/ProjectConversion/v3_3/PassiveTransportBuildignBlockConversionSpecs.cs
deleted file mode 100644
index cd055ee19..000000000
--- a/tests/MoBi.Tests/ProjectConversion/v3_3/PassiveTransportBuildignBlockConversionSpecs.cs
+++ /dev/null
@@ -1,35 +0,0 @@
-using System.Linq;
-using OSPSuite.BDDHelper;
-using OSPSuite.BDDHelper.Extensions;
-using MoBi.Core;
-using MoBi.IntegrationTests;
-using OSPSuite.Core.Domain.Builder;
-using OSPSuite.Core.Domain.Formulas;
-
-namespace MoBi.ProjectConversion.v3_3
-{
-   public abstract class concern_for_PassiveTransportBuildignBlockConversionSpecs : ContextWithLoadedProject
-   {
-      protected IPassiveTransportBuildingBlock _passiveTransportBuildingBlock;
-
-      public override void GlobalContext()
-      {
-         base.GlobalContext();
-         _passiveTransportBuildingBlock = LoadPKML<IPassiveTransportBuildingBlock>("Passive Transports");
-      }
-   }
-
-   internal class When_converting_an_passive_tranport_building_block : concern_for_PassiveTransportBuildignBlockConversionSpecs
-   {
-      [Observation]
-      public void should_have_changed_GallbladderEmptyin_Transport()
-      {
-         var gallbladderEmptying = _passiveTransportBuildingBlock.FirstOrDefault(pt => pt.Name.Equals("GallbladderEmptying"));
-         gallbladderEmptying.ShouldNotBeNull();
-         var kinetic = ((ExplicitFormula) gallbladderEmptying.Formula);
-         kinetic.FormulaString.ShouldBeEqualTo("EHC_Active ? ln(2) / EHC_Halftime * M * EHC_EjectionFraction : 0");
-         var alias = kinetic.ObjectPaths.Select(op => op.Alias);
-         alias.ShouldOnlyContain("EHC_Active", "EHC_Halftime", "M", "EHC_EjectionFraction");
-      }
-   }
-}
\ No newline at end of file
diff --git a/tests/MoBi.Tests/ProjectConversion/v3_3/ProjectConversion33IntegrationTest.cs b/tests/MoBi.Tests/ProjectConversion/v3_3/ProjectConversion33IntegrationTest.cs
deleted file mode 100644
index c35677824..000000000
--- a/tests/MoBi.Tests/ProjectConversion/v3_3/ProjectConversion33IntegrationTest.cs
+++ /dev/null
@@ -1,73 +0,0 @@
-using System.Linq;
-using OSPSuite.BDDHelper;
-using OSPSuite.BDDHelper.Extensions;
-using MoBi.Core;
-using MoBi.Core.Serialization.Converter.v3_3;
-using MoBi.IntegrationTests;
-using OSPSuite.Core.Domain;
-using OSPSuite.Core.Domain.Builder;
-using OSPSuite.Core.Domain.Formulas;
-using OSPSuite.Core.Serialization.Exchange;
-
-namespace MoBi.ProjectConversion.v3_3
-{
-   public abstract class concern_for_ProjectConversionIntegrationTest : ContextWithLoadedProject
-   {
-      protected SimulationTransfer _simulationTransfer;
-
-      public override void GlobalContext()
-      {
-         base.GlobalContext();
-         _simulationTransfer = LoadPKML<SimulationTransfer>("523_Export_S1");
-      }
-   }
-
-   internal class When_converting_project_523_Export_S1 : concern_for_ProjectConversionIntegrationTest
-   {
-      protected IEventGroupBuildingBlock _eventGroupBuildingBlock;
-
-      protected override void Context()
-      {
-         base.Context();
-         _eventGroupBuildingBlock = _simulationTransfer.Simulation.BuildConfiguration.EventGroups;
-      }
-
-      [Observation]
-      public void should_have_changed_GallbladderEmptyin_Transport()
-      {
-         var passiveTransportBuildingBlock = _simulationTransfer.Simulation.BuildConfiguration.PassiveTransports;
-         var gallbladderEmptying = passiveTransportBuildingBlock.FirstOrDefault(pt => pt.Name.Equals("GallbladderEmptying"));
-         gallbladderEmptying.ShouldNotBeNull();
-         var kinetic = ((ExplicitFormula) gallbladderEmptying.Formula);
-         kinetic.FormulaString.ShouldBeEqualTo("EHC_Active ? ln(2) / EHC_Halftime * M * EHC_EjectionFraction : 0");
-         var alias = kinetic.ObjectPaths.Select(op => op.Alias);
-         alias.ShouldOnlyContain("EHC_Active", "EHC_Halftime", "M", "EHC_EjectionFraction");
-      }
-
-      [Observation]
-      public void should_change_EHC_Start_event_to_assign_Gallbladder_emptying_active()
-      {
-         var eventGroup = _eventGroupBuildingBlock.First(eg => eg.Name.Equals("EHC"));
-         eventGroup = eventGroup.GetSingleChildByName<EventGroupBuilder>("EHC_1");
-         var ehcStartEvent = eventGroup.GetSingleChildByName<IEventBuilder>(Converter321To331.EHCStartEvent);
-         var assingment = ehcStartEvent.Assignments.FirstOrDefault(a => a.ObjectPath.PathAsString.Equals("Organism|Gallbladder|Gallbladder emptying active"));
-         assingment.ShouldNotBeNull();
-         assingment.UseAsValue.ShouldBeFalse();
-         assingment.Formula.IsConstant().ShouldBeTrue();
-         ((ConstantFormula) assingment.Formula).Value.ShouldBeEqualTo(1);
-      }
-
-      [Observation]
-      public void should_change_EHC_Stop_event_to_assign_Gallbladder_emptying_active()
-      {
-         var eventGroup = _eventGroupBuildingBlock.First(eg => eg.Name.Equals("EHC"));
-         eventGroup = eventGroup.GetSingleChildByName<EventGroupBuilder>("EHC_1");
-         var ehcStopEvent = eventGroup.GetSingleChildByName<IEventBuilder>(Converter321To331.EHCStopEvent);
-         var assingment = ehcStopEvent.Assignments.FirstOrDefault(a => a.ObjectPath.PathAsString.Equals("Organism|Gallbladder|Gallbladder emptying active"));
-         assingment.ShouldNotBeNull();
-         assingment.UseAsValue.ShouldBeTrue();
-         assingment.Formula.IsConstant().ShouldBeTrue();
-         ((ConstantFormula) assingment.Formula).Value.ShouldBeEqualTo(0);
-      }
-   }
-}
\ No newline at end of file
diff --git a/tests/MoBi.Tests/ProjectConversion/v3_5/331_TestGISpecs.cs b/tests/MoBi.Tests/ProjectConversion/v3_5/331_TestGISpecs.cs
deleted file mode 100644
index 053d15037..000000000
--- a/tests/MoBi.Tests/ProjectConversion/v3_5/331_TestGISpecs.cs
+++ /dev/null
@@ -1,46 +0,0 @@
-using System.Linq;
-using OSPSuite.BDDHelper;
-using OSPSuite.BDDHelper.Extensions;
-using OSPSuite.Utility.Extensions;
-using MoBi.Core.Domain.Model;
-using MoBi.IntegrationTests;
-using OSPSuite.Core.Domain;
-using OSPSuite.Core.Domain.Formulas;
-
-namespace MoBi.ProjectConversion.v3_5
-{
-   public class When_converting_the_331_TestGI_project : ContextWithLoadedProject
-   {
-      private IMoBiProject _project;
-      private IMoBiSpatialStructure _spatialStructure;
-      private IContainer _organism;
-
-      public override void GlobalContext()
-      {
-         base.GlobalContext();
-         _project = LoadProject("331_TestGI");
-         _spatialStructure = _project.SpatialStructureCollection.First();
-         _organism = _spatialStructure.TopContainers.FindByName(Constants.ORGANISM);
-      }
-
-
-      [Observation]
-      public void should_have_created_the_parameter_for_surface_area()
-      {
-         var aeff = _organism.EntityAt<IParameter>("Lumen", "Duodenum","Effective surface area");
-         aeff.ShouldNotBeNull();
-         aeff.Formula.IsExplicit().ShouldBeTrue();
-         aeff.Formula.DowncastTo<ExplicitFormula>().FormulaString.ShouldBeEqualTo("Ageom * AeffFactor * AeffVariabilityFactor");
-      }
-
-      [Observation]
-      public void should_have_added_the_variability_parameter()
-      {
-         var factor = _organism.EntityAt<IDistributedParameter>("Lumen", "Effective surface area variability factor");
-         factor.ShouldNotBeNull();
-         factor.EntityAt<IParameter>(Constants.Distribution.GEOMETRIC_DEVIATION).Value.ShouldBeEqualTo(1.6);
-         factor.EntityAt<IParameter>(Constants.Distribution.PERCENTILE).Value.ShouldBeEqualTo(0.5);
-         factor.EntityAt<IParameter>(Constants.Distribution.MEAN).Value.ShouldBeEqualTo(1);
-      }
-   }
-}
\ No newline at end of file
diff --git a/tests/MoBi.Tests/ProjectConversion/v3_5/BuildConfiguration_341Specs.cs b/tests/MoBi.Tests/ProjectConversion/v3_5/BuildConfiguration_341Specs.cs
deleted file mode 100644
index e42d57a79..000000000
--- a/tests/MoBi.Tests/ProjectConversion/v3_5/BuildConfiguration_341Specs.cs
+++ /dev/null
@@ -1,25 +0,0 @@
-using OSPSuite.BDDHelper;
-using OSPSuite.BDDHelper.Extensions;
-using MoBi.Core.Domain.Model;
-using MoBi.IntegrationTests;
-using OSPSuite.Core.Domain.Builder;
-
-namespace MoBi.ProjectConversion.v3_5
-{
-   public class When_loading_a_build_configuration_from_a_523_project : ContextWithLoadedProject
-   {
-      private BuildConfiguration _buildConfiguration;
-
-      public override void GlobalContext()
-      {
-         base.GlobalContext();
-         _buildConfiguration = LoadPKML<MoBiBuildConfiguration>("523_Export_S1");
-      }
-
-      [Observation]
-      public void should_have_defined_a_default_simulation_setting()
-      {
-         _buildConfiguration.SimulationSettings.ShouldNotBeNull();
-      }
-   }
-}
\ No newline at end of file
diff --git a/tests/MoBi.Tests/ProjectConversion/v3_5/MoBiSimulation3_4Specs.cs b/tests/MoBi.Tests/ProjectConversion/v3_5/MoBiSimulation3_4Specs.cs
deleted file mode 100644
index 9a76637e2..000000000
--- a/tests/MoBi.Tests/ProjectConversion/v3_5/MoBiSimulation3_4Specs.cs
+++ /dev/null
@@ -1,26 +0,0 @@
-using OSPSuite.BDDHelper;
-using OSPSuite.BDDHelper.Extensions;
-using OSPSuite.Utility.Extensions;
-using MoBi.Core.Domain.Model;
-using MoBi.IntegrationTests;
-using OSPSuite.Core.Serialization.Exchange;
-
-namespace MoBi.ProjectConversion.v3_5
-{
-   public class When_converting_the_MoBiSimulation3_4 : ContextWithLoadedProject
-   {
-      private IMoBiSimulation _simulation;
-
-      protected override void Context()
-      {
-         base.Context();
-         _simulation = LoadPKML<IMoBiSimulation>("MoBiSimulation3_4");
-      }
-
-      [Observation]
-      public void should_have_loaded_the_ParameterIdentificationWorkingDirectory_as_defined_in_the_project()
-      {
-         _simulation.ParameterIdentificationWorkingDirectory.ShouldNotBeNull();
-      }
-   }
-}
\ No newline at end of file
diff --git a/tests/MoBi.Tests/ProjectConversion/v3_5/ModelCoreSimulation3_0Specs.cs b/tests/MoBi.Tests/ProjectConversion/v3_5/ModelCoreSimulation3_0Specs.cs
deleted file mode 100644
index 02e1d31d9..000000000
--- a/tests/MoBi.Tests/ProjectConversion/v3_5/ModelCoreSimulation3_0Specs.cs
+++ /dev/null
@@ -1,24 +0,0 @@
-using OSPSuite.BDDHelper;
-using OSPSuite.BDDHelper.Extensions;
-using MoBi.Core.Domain.Model;
-using MoBi.IntegrationTests;
-
-namespace MoBi.ProjectConversion.v3_5
-{
-   public class When_converting_the_concern_for_ModelCoreSimulation3_0_simulation : ContextWithLoadedProject
-   {
-      private IMoBiSimulation _simulation;
-
-      protected override void Context()
-      {
-         base.Context();
-         _simulation = LoadPKML<IMoBiSimulation>("ModelCoreSimulation3_0");
-      }
-
-      [Observation]
-      public void should_have_a_simulation_with_a_simulation_settings()
-      {
-         _simulation.BuildConfiguration.SimulationSettings.ShouldNotBeNull();
-      }
-   }
-}
\ No newline at end of file
diff --git a/tests/MoBi.Tests/ProjectConversion/v3_5/SimpleProject_341Specs.cs b/tests/MoBi.Tests/ProjectConversion/v3_5/SimpleProject_341Specs.cs
deleted file mode 100644
index 688c80eb0..000000000
--- a/tests/MoBi.Tests/ProjectConversion/v3_5/SimpleProject_341Specs.cs
+++ /dev/null
@@ -1,60 +0,0 @@
-using System.Linq;
-using OSPSuite.BDDHelper;
-using OSPSuite.BDDHelper.Extensions;
-using MoBi.Core.Domain.Model;
-using MoBi.IntegrationTests;
-using OSPSuite.Core.Domain;
-using OSPSuite.Core.Domain.Services;
-
-namespace MoBi.ProjectConversion.v3_5
-{
-   public class When_converting_the_simple_project_341 : ContextWithLoadedProject
-   {
-      private IMoBiProject _project;
-      private IMoBiSimulation _simulation;
-
-      public override void GlobalContext()
-      {
-         base.GlobalContext();
-         _project = LoadProject("SimpleProject_341");
-         _simulation = _project.Simulations.First();
-      }
-
-      [Observation]
-      public void should_have_added_a_simulation_settings_building_block_to_the_template()
-      {
-         _project.SimulationSettingsCollection.Any().ShouldBeTrue();
-      }
-
-      [Observation]
-      public void should_have_ensured_that_the_simulation_is_referencing_the_simulation_settings_template()
-      {
-         _simulation.MoBiBuildConfiguration.SimulationSettingsInfo.TemplateBuildingBlock
-            .ShouldBeEqualTo(_project.SimulationSettingsCollection.First());
-      }
-
-      [Observation]
-      public void should_have_set_the_project_mode_to_amount()
-      {
-         _project.ReactionDimensionMode.ShouldBeEqualTo(ReactionDimensionMode.AmountBased);
-      }
-
-      [Observation]
-      public void should_have_added_the_volume_parameter_to_all_physical_containers()
-      {
-         foreach (var container in _project.SpatialStructureCollection.SelectMany(x => x.PhysicalContainers))
-         {
-            container.ContainsName(Constants.Parameters.VOLUME).ShouldBeTrue();
-         }
-      }
-
-      [Observation]
-      public void should_have_added_the_concentration_parameter_to_all_molecule_builder()
-      {
-         foreach (var moleculeBuilder in _project.MoleculeBlockCollection.SelectMany(x => x))
-         {
-            moleculeBuilder.ContainsName(Constants.Parameters.CONCENTRATION).ShouldBeTrue();
-         }
-      }
-   }
-}
\ No newline at end of file
diff --git a/tests/MoBi.Tests/ProjectConversion/v6_0/Converter36To601Specs.cs b/tests/MoBi.Tests/ProjectConversion/v6_0/Converter36To601Specs.cs
deleted file mode 100644
index 05cf50d5b..000000000
--- a/tests/MoBi.Tests/ProjectConversion/v6_0/Converter36To601Specs.cs
+++ /dev/null
@@ -1,44 +0,0 @@
-using System.Linq;
-using OSPSuite.BDDHelper;
-using OSPSuite.BDDHelper.Extensions;
-using MoBi.Core.Domain.Model;
-using MoBi.IntegrationTests;
-using OSPSuite.Core.Domain.Services;
-using OSPSuite.Core.Serialization.Exchange;
-
-namespace MoBi.ProjectConversion.v6_0
-{
-   public class When_converting_a_project_from_3_6_to_6_0 : ContextWithLoadedProject
-   {
-      private IMoBiProject _project;
-
-      public override void GlobalContext()
-      {
-         base.GlobalContext();
-         _project = LoadProject("EB_LV");
-      }
-
-      [Observation]
-      public void should_be_able_to_load_a_project_with_display_dimension_map_using_a_per_Time_attribute()
-      {
-         _project.DisplayUnits.AllDisplayUnits.Count().ShouldBeEqualTo(2);
-      }
-   }
-
-   public class When_converting_a_pkml_from_3_6_to_6_0 : ContextWithLoadedProject
-   {
-      private SimulationTransfer _simulation;
-
-      public override void GlobalContext()
-      {
-         base.GlobalContext();
-         _simulation = LoadPKML<SimulationTransfer>("run", ReactionDimensionMode.ConcentrationBased);
-      }
-
-      [Observation]
-      public void should_be_able_to_load_a_project_with_display_dimension_map_using_a_per_Time_attribute()
-      {
-         _simulation.ShouldNotBeNull();
-      }
-   }
-}
\ No newline at end of file
diff --git a/tests/MoBi.Tests/ProjectConversion/v9/Converter730To90Specs.cs b/tests/MoBi.Tests/ProjectConversion/v9/Converter730To90Specs.cs
new file mode 100644
index 000000000..ee0227552
--- /dev/null
+++ b/tests/MoBi.Tests/ProjectConversion/v9/Converter730To90Specs.cs
@@ -0,0 +1,24 @@
+using MoBi.Core.Domain.Model;
+using MoBi.IntegrationTests;
+using OSPSuite.BDDHelper;
+using OSPSuite.BDDHelper.Extensions;
+
+namespace MoBi.ProjectConversion.v9
+{
+   public class When_converting_a_project_to_9_0 : ContextWithLoadedProject
+   {
+      private IMoBiProject _project;
+
+      public override void GlobalContext()
+      {
+         base.GlobalContext();
+         _project = LoadProject("EB_LV");
+      }
+
+      [Observation]
+      public void should_have_loaded_the_project_as_expected()
+      {
+         _project.ShouldNotBeNull();
+      }
+   }
+}
\ No newline at end of file
diff --git a/tests/MoBi.Tests/Properties/AssemblyInfo.cs b/tests/MoBi.Tests/Properties/AssemblyInfo.cs
deleted file mode 100644
index a6b53bd68..000000000
--- a/tests/MoBi.Tests/Properties/AssemblyInfo.cs
+++ /dev/null
@@ -1,7 +0,0 @@
-using System.Reflection;
-
-// General Information about an assembly is controlled through the following 
-// set of attributes. Change these attribute values to modify the information
-// associated with an assembly.
-
-[assembly: AssemblyTitle("MoBi.Tests")]
\ No newline at end of file
diff --git a/tests/MoBi.Tests/Templates/BTSTemplate/BTSLogo.pdf b/tests/MoBi.Tests/Templates/BTSTemplate/BTSLogo.pdf
deleted file mode 100644
index 2a095e4c2..000000000
Binary files a/tests/MoBi.Tests/Templates/BTSTemplate/BTSLogo.pdf and /dev/null differ
diff --git a/tests/MoBi.Tests/Templates/BTSTemplate/BTSTemplate.json b/tests/MoBi.Tests/Templates/BTSTemplate/BTSTemplate.json
deleted file mode 100644
index c97b97fcc..000000000
--- a/tests/MoBi.Tests/Templates/BTSTemplate/BTSTemplate.json
+++ /dev/null
@@ -1,4 +0,0 @@
-{
-  "DisplayName": "Bayer Technology Services GmbH",
-  "Description": "Standard template with BTS logo in footer."
-}
\ No newline at end of file
diff --git a/tests/MoBi.Tests/Templates/BTSTemplate/BTSTemplate.tex b/tests/MoBi.Tests/Templates/BTSTemplate/BTSTemplate.tex
deleted file mode 100644
index a2ce028bb..000000000
--- a/tests/MoBi.Tests/Templates/BTSTemplate/BTSTemplate.tex
+++ /dev/null
@@ -1,41 +0,0 @@
-\documentclass[a4paper, titlepage, oneside]{report}
-
-\newcommand{\COLORSTYLE}[1]{\newcommand{\Colorstyle}{#1}}
-\COLORSTYLE{@COLORSTYLE}
-
-\newcommand{\DRAFT}[1]{\newcommand{\Draft}{#1}}
-\DRAFT{@DRAFT}
-
-\newcommand{\FONT}[1]{\newcommand{\Font}{#1}}
-\FONT{@FONT}
-
-\usepackage{SBSuite}
-
-%set values for placeholder variables
-\AUTHOR{@AUTHOR}
-\TITLE{@TITLE}
-\SUBTITLE{@SUBTITLE}
-\KEYWORDS{@KEYWORDS}
-\CONTENTFILE{@CONTENTFILE}
-%technical information
-\SOFTWARE{@SOFTWARE}
-\SOFTWAREVERSION{@SOFTWAREVERSION}
-\PLATFORM{@PLATFORM}
-
-\title{\Title\\\SubTitle}
-\author{\Author}
-
-\PDFSettings
-
-\PageSetupWithLogo{BTSLogo}
-
-\begin{document}
-\TitlePage
-
-\TableOfContentsPages
-
-\include{\ContentFile}
-
-%\TechnicalInformation
-
-\end{document}
\ No newline at end of file
diff --git a/tests/MoBi.Tests/Templates/BTSTemplate/SBSuite.sty b/tests/MoBi.Tests/Templates/BTSTemplate/SBSuite.sty
deleted file mode 100644
index 388fe4724..000000000
--- a/tests/MoBi.Tests/Templates/BTSTemplate/SBSuite.sty
+++ /dev/null
@@ -1,306 +0,0 @@
-\NeedsTeXFormat{LaTeX2e}[1994/06/01]
-\ProvidesPackage{SBSuite}
-  [2013/06/13 v0.01 LaTeX package for SBSuite report generator]
-
-%define placeholder variables
-\newcommand{\AUTHOR}[1]{\newcommand{\Author}{#1}}
-\newcommand{\TITLE}[1]{\newcommand{\Title}{#1}}
-\newcommand{\SUBTITLE}[1]{\newcommand{\SubTitle}{#1}}
-\newcommand{\KEYWORDS}[1]{\newcommand{\Keywords}{#1}}
-\newcommand{\CONTENTFILE}[1]{\newcommand{\ContentFile}{#1}}
-%technical placeholders
-\newcommand{\SOFTWARE}[1]{\newcommand{\Software}{#1}}
-\newcommand{\SOFTWAREVERSION}[1]{\newcommand{\SoftwareVersion}{#1}}
-\newcommand{\PLATFORM}[1]{\newcommand{\Platform}{#1}}
-\newcommand{\MIKTEXVERSION}[1]{\newcommand{\MikTEXVersion}{#1}}
-\MIKTEXVERSION{MikTEX Portable 2.9}
-
-%use of packages
-\usepackage[\Colorstyle]{xcolor}
-\usepackage[export]{adjustbox}
-\usepackage{float}
-\usepackage{pdflscape}
-\usepackage{grffile}
-\usepackage{tabu}
-\usepackage{longtable}
-\usepackage{needspace}
-\usepackage[labelfont=bf]{caption}
-\usepackage{threeparttablex}
-\usepackage{textcomp}
-\usepackage[linktocpage=true,colorlinks=false, linkcolor=blue, linkbordercolor=blue]{hyperref}
-\usepackage{fancyhdr}
-\usepackage{lastpage}
-\usepackage[\Draft]{draftwatermark}
-\usepackage{tikz}
-\usepackage{sectsty}
-\usepackage[section]{placeins}
-\usepackage{tcolorbox}
-\tcbuselibrary{breakable}
-\usepackage{pgfplots}
-\pgfplotsset{compat=1.8}
-%\usepgfplotslibrary{clickable}
-\usepgfplotslibrary{external}
-\usepgfplotslibrary{statistics} % LATEX and plain TEX
-\usepgfplotslibrary{groupplots}
-\tikzexternalize[prefix=plots/]
-\tikzsetfigurename{plot}
-
-\usepackage{ifthen}
-
-%use helvetica as font
-\def\Helvetica {
-  \usepackage[scaled]{helvet}
-  \renewcommand*\familydefault{\sfdefault}
-  \usepackage[T1]{fontenc}
-  \SetWatermarkScale{1}
-}
-
-\def\Optima {
-  \renewcommand*\sfdefault{uop}
-  \renewcommand*\familydefault{\sfdefault} 
-  \usepackage[T1]{fontenc}
-  \SetWatermarkScale{5}
-}
-
-\def\ComputerModernTeletype {
-  \usepackage[T1]{fontenc}
-  \renewcommand*\familydefault{\ttdefault}
-  \SetWatermarkScale{5}
-}
-
-\def\Courier {
-\usepackage{courier}
-\renewcommand*\familydefault{\ttdefault} 
-\usepackage[T1]{fontenc}
-}
-
-\def\Bookman {
-\usepackage{bookman}
-\usepackage[T1]{fontenc}
-}
-
-\def\Inconsolata {
-\renewcommand*\familydefault{\ttdefault} 
-\usepackage[T1]{fontenc}
-}
-
-\def\LatinModern {
-\usepackage{lmodern}
-\usepackage[T1]{fontenc}
-}
-
-\def\FontSelection #1{
-  \ifthenelse{\equal{#1}{Helvetica}}{\Helvetica}
-    {\ifthenelse{\equal{#1}{Optima}}{\Optima}
-      {\ifthenelse{\equal{#1}{ComputerModernTeletype}}{\ComputerModernTeletype}
-         {\ifthenelse{\equal{#1}{Courier}}{\Courier}
-            {\ifthenelse{\equal{#1}{Bookman}}{\Bookman}
-               {\ifthenelse{\equal{#1}{Inconsolata}}{\Inconsolata}
-                  {\ifthenelse{\equal{#1}{LatinModern}}{\LatinModern}
-                     {\SetWatermarkScale{6}}
-                  }
-               }
-            }
-         }
-      }
-   }
-}
-
-\FontSelection{\Font}
-
-\usepackage{siunitx}
-\def\alignnumbers#1{\tablenum[group-digits=false]{#1}}
-
-%new command for multi level groupings in plots
-% #1 start x coordinate
-% #2 end x coordinate
-% #3 text
-% #4 level, used for yshifting
-\pgfplotsset{
-    group line offset/.initial=4ex,
-    text offset/.initial=0ex,
-    group line extend/.initial=3pt,
-    draw group line/.style n args={4}{
-        after end axis/.append code={
-	\coordinate [yshift=-(5pt + \pgfkeysvalueof{/pgfplots/group line offset}) * #4 - \pgfkeysvalueof{/pgfplots/text offset}] (startgroup) at ({axis cs: #1,1} |- {rel axis cs:0,0});
-	\coordinate [yshift=-(5pt + \pgfkeysvalueof{/pgfplots/group line offset}) * #4 - \pgfkeysvalueof{/pgfplots/text offset}] (endgroup) at ({axis cs:#2,1} |- {rel axis cs:0,0});
-           \draw [decorate,decoration={brace,amplitude=5pt, mirror},
-                  shorten >=-\pgfkeysvalueof{/pgfplots/group line extend},
-                  shorten <=-\pgfkeysvalueof{/pgfplots/group line extend},
-           ] (startgroup) -- node [anchor=north, yshift=-5pt] {#3} (endgroup);
-        }
-    }
-}
-
-\allsectionsfont{\raggedright}
-
-\tcbset{breakable,
-             lowerbox=ignored, 
-             colframe=gray!80, 
-             fonttitle=\bfseries\large,
-             space=0,
-             colback=gray!5,
-             coltitle=white, 
-             toprule at break=0pt,
-             bottomrule at break=0pt, 
-             title after break=continued from previous page}
-\newcommand\textbox[2]{
-	\begin{center}
-		\begin{tcolorbox}[title=#1]
-			#2
-		\end{tcolorbox}
-	\end{center}
-}
-
-\setlength{\LTpre}{0pt}
-\setlength{\LTpost}{0pt}
-\setlength{\tabulinesep}{3pt}
-\captionsetup[longtable]{position=b} 
-
-\setcounter{chapter}{0}
-\setcounter{secnumdepth}{5}
-\setcounter{tocdepth}{5}
-\makeatletter\@addtoreset{chapter}{part}\makeatother
-
-\parindent 0pt
-
-\hypersetup{
-	pdflinkmargin=2pt
-}
-
-\def\PDFSettings{
-\hypersetup{
-	pdfsubject = {\Title},
-	pdftitle = {\SubTitle},
-	pdfauthor = {\Author},
-	pdfkeywords = \Keywords,
-	pdfproducer = {\Software~\SoftwareVersion}
-}
-}
-
-\def\StandardPageSetup{
-\usepackage[a4paper, left=2cm, right=2cm, top=1cm, bottom=1cm, footskip=1.5cm, includeheadfoot]{geometry}
-
-\pagestyle{fancy}
-\fancyhead{}
-\fancyfoot{}
-
-%line thickness for header and footer
-\renewcommand{\headrulewidth}{0.4pt}
-\renewcommand{\footrulewidth}{0.4pt}
-
-\fancyhead[R]{\textit{\nouppercase{\slshape}} \textit{\nouppercase{\rightmark}}}
-\fancyhead[L]{\textit{\nouppercase{\slshape}} \textit{\nouppercase{\leftmark}}}
-\fancyfoot[C]{\SubTitle}
-\fancyfoot[L]{\Title}
-\fancyfoot[R]{Page \thepage~of~\pageref{LastPage}}
-
-\fancypagestyle{plain}{%
-	\fancyhf{}%
-	\fancyhead[C]{} %no header
-	\renewcommand{\headrulewidth}{0.0pt} %no header line
-	\fancyfoot[C]{\SubTitle}
-	\fancyfoot[L]{\Title}
-	\fancyfoot[R]{Page \thepage~of~\pageref{LastPage}}
-}
-}
-
-\def\PageSetupWithLogo #1{
-\usepackage[a4paper, left=2cm, right=2cm, top=1cm, bottom=0.1cm, footskip=2.4cm, includeheadfoot]{geometry}
-
-\pagestyle{fancy}
-\fancyhead{}
-\fancyfoot{}
-
-%line thickness for header and footer
-\renewcommand{\headrulewidth}{0.4pt}
-\renewcommand{\footrulewidth}{0.4pt}
-
-\newcommand\myfooter{
-	\fancyfoot[L]{
-		\begin{tabular}[b]{p{0.6\textwidth}}
-			\Title\\\relax 
-			\SubTitle\\\relax
-		\end{tabular}
-	}
-	\fancyfoot[C]{}
-	\fancyfoot[R]{
-		\begin{tabular}[b]{r}
-			Page \thepage~of~\pageref{LastPage}\\\relax 
-			\includegraphics[height=22pt]{#1}\\\relax
-		\end{tabular}
-	}
-}
-
-\fancyhead[L]{\textit{\nouppercase{\slshape}} \textit{\nouppercase{\leftmark}}}
-\fancyhead[R]{\textit{\nouppercase{\slshape}} \textit{\nouppercase{\rightmark}}}
-\myfooter
-
-\fancypagestyle{plain}{%
-	\fancyhf{}%
-	\fancyhead[C]{} %no header
-	\renewcommand{\headrulewidth}{0.0pt} %no header line
-	\myfooter
-}
-}
-
-\fancypagestyle{empty}{          
-	\fancyhf{}    
-	\renewcommand{\headrulewidth}{0.0pt} %no header line           
-	\renewcommand{\footrulewidth}{0.0pt} %no footer line    
-	\fancyhead[C]{} %no header           
-	\fancyfoot[C]{Generated using \Software~\SoftwareVersion.}
-	\footskip=50pt
-}
-
-\def\TitlePage{
-\clearpage
-\phantomsection
-\pdfbookmark[1]{Title}{title}
-\maketitle
-}
-
-\def\TableOfContentsPages{
-\clearpage
-\phantomsection
-\pdfbookmark[1]{Table of Contents}{toc}
-\tableofcontents
-\pagebreak
-}
-
-\def\TechnicalInformation{
-\part{Technical Information}
-
-\par{
-This report was generated by \Software~\SoftwareVersion ~on \today, with \MikTEXVersion, on a \Platform ~platform.
-}
-\\
-
-For the report generation following \LaTeX{} packages have been used:
-\begin{itemize}
-  \item \texttt{xcolor} 
-  \item \texttt{adjustbox} 
-  \item \texttt{float}   
-  \item \texttt{pdflscape} 
-  \item \texttt{grffile} 
-  \item \texttt{tabu}
-  \item \texttt{longtable} 
-  \item \texttt{needspace} 
-  \item \texttt{caption} 
-  \item \texttt{threeparttablex} 
-  \item \texttt{textcomp}
-  \item \texttt{hyperref}
-  \item \texttt{fancyhdr}
-  \item \texttt{lastpage}
-  \item \texttt{draftwatermark}
-  \item \texttt{geometry}
-  \item \texttt{tikz}
-  \item \texttt{sectsty}  
-  \item \texttt{placeins}  
-  \item \texttt{tcolorbox}  
-  \item \texttt{pgfplots}
-  \item \texttt{siunitx}
-\end{itemize}
-}
-
-\endinput
\ No newline at end of file
diff --git a/tests/MoBi.Tests/Templates/StandardTemplate/SBSuite.sty b/tests/MoBi.Tests/Templates/StandardTemplate/SBSuite.sty
deleted file mode 100644
index 388fe4724..000000000
--- a/tests/MoBi.Tests/Templates/StandardTemplate/SBSuite.sty
+++ /dev/null
@@ -1,306 +0,0 @@
-\NeedsTeXFormat{LaTeX2e}[1994/06/01]
-\ProvidesPackage{SBSuite}
-  [2013/06/13 v0.01 LaTeX package for SBSuite report generator]
-
-%define placeholder variables
-\newcommand{\AUTHOR}[1]{\newcommand{\Author}{#1}}
-\newcommand{\TITLE}[1]{\newcommand{\Title}{#1}}
-\newcommand{\SUBTITLE}[1]{\newcommand{\SubTitle}{#1}}
-\newcommand{\KEYWORDS}[1]{\newcommand{\Keywords}{#1}}
-\newcommand{\CONTENTFILE}[1]{\newcommand{\ContentFile}{#1}}
-%technical placeholders
-\newcommand{\SOFTWARE}[1]{\newcommand{\Software}{#1}}
-\newcommand{\SOFTWAREVERSION}[1]{\newcommand{\SoftwareVersion}{#1}}
-\newcommand{\PLATFORM}[1]{\newcommand{\Platform}{#1}}
-\newcommand{\MIKTEXVERSION}[1]{\newcommand{\MikTEXVersion}{#1}}
-\MIKTEXVERSION{MikTEX Portable 2.9}
-
-%use of packages
-\usepackage[\Colorstyle]{xcolor}
-\usepackage[export]{adjustbox}
-\usepackage{float}
-\usepackage{pdflscape}
-\usepackage{grffile}
-\usepackage{tabu}
-\usepackage{longtable}
-\usepackage{needspace}
-\usepackage[labelfont=bf]{caption}
-\usepackage{threeparttablex}
-\usepackage{textcomp}
-\usepackage[linktocpage=true,colorlinks=false, linkcolor=blue, linkbordercolor=blue]{hyperref}
-\usepackage{fancyhdr}
-\usepackage{lastpage}
-\usepackage[\Draft]{draftwatermark}
-\usepackage{tikz}
-\usepackage{sectsty}
-\usepackage[section]{placeins}
-\usepackage{tcolorbox}
-\tcbuselibrary{breakable}
-\usepackage{pgfplots}
-\pgfplotsset{compat=1.8}
-%\usepgfplotslibrary{clickable}
-\usepgfplotslibrary{external}
-\usepgfplotslibrary{statistics} % LATEX and plain TEX
-\usepgfplotslibrary{groupplots}
-\tikzexternalize[prefix=plots/]
-\tikzsetfigurename{plot}
-
-\usepackage{ifthen}
-
-%use helvetica as font
-\def\Helvetica {
-  \usepackage[scaled]{helvet}
-  \renewcommand*\familydefault{\sfdefault}
-  \usepackage[T1]{fontenc}
-  \SetWatermarkScale{1}
-}
-
-\def\Optima {
-  \renewcommand*\sfdefault{uop}
-  \renewcommand*\familydefault{\sfdefault} 
-  \usepackage[T1]{fontenc}
-  \SetWatermarkScale{5}
-}
-
-\def\ComputerModernTeletype {
-  \usepackage[T1]{fontenc}
-  \renewcommand*\familydefault{\ttdefault}
-  \SetWatermarkScale{5}
-}
-
-\def\Courier {
-\usepackage{courier}
-\renewcommand*\familydefault{\ttdefault} 
-\usepackage[T1]{fontenc}
-}
-
-\def\Bookman {
-\usepackage{bookman}
-\usepackage[T1]{fontenc}
-}
-
-\def\Inconsolata {
-\renewcommand*\familydefault{\ttdefault} 
-\usepackage[T1]{fontenc}
-}
-
-\def\LatinModern {
-\usepackage{lmodern}
-\usepackage[T1]{fontenc}
-}
-
-\def\FontSelection #1{
-  \ifthenelse{\equal{#1}{Helvetica}}{\Helvetica}
-    {\ifthenelse{\equal{#1}{Optima}}{\Optima}
-      {\ifthenelse{\equal{#1}{ComputerModernTeletype}}{\ComputerModernTeletype}
-         {\ifthenelse{\equal{#1}{Courier}}{\Courier}
-            {\ifthenelse{\equal{#1}{Bookman}}{\Bookman}
-               {\ifthenelse{\equal{#1}{Inconsolata}}{\Inconsolata}
-                  {\ifthenelse{\equal{#1}{LatinModern}}{\LatinModern}
-                     {\SetWatermarkScale{6}}
-                  }
-               }
-            }
-         }
-      }
-   }
-}
-
-\FontSelection{\Font}
-
-\usepackage{siunitx}
-\def\alignnumbers#1{\tablenum[group-digits=false]{#1}}
-
-%new command for multi level groupings in plots
-% #1 start x coordinate
-% #2 end x coordinate
-% #3 text
-% #4 level, used for yshifting
-\pgfplotsset{
-    group line offset/.initial=4ex,
-    text offset/.initial=0ex,
-    group line extend/.initial=3pt,
-    draw group line/.style n args={4}{
-        after end axis/.append code={
-	\coordinate [yshift=-(5pt + \pgfkeysvalueof{/pgfplots/group line offset}) * #4 - \pgfkeysvalueof{/pgfplots/text offset}] (startgroup) at ({axis cs: #1,1} |- {rel axis cs:0,0});
-	\coordinate [yshift=-(5pt + \pgfkeysvalueof{/pgfplots/group line offset}) * #4 - \pgfkeysvalueof{/pgfplots/text offset}] (endgroup) at ({axis cs:#2,1} |- {rel axis cs:0,0});
-           \draw [decorate,decoration={brace,amplitude=5pt, mirror},
-                  shorten >=-\pgfkeysvalueof{/pgfplots/group line extend},
-                  shorten <=-\pgfkeysvalueof{/pgfplots/group line extend},
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diff --git a/tests/MoBi.Tests/Templates/StandardTemplate/StandardTemplate.json b/tests/MoBi.Tests/Templates/StandardTemplate/StandardTemplate.json
deleted file mode 100644
index c6a8ccd95..000000000
--- a/tests/MoBi.Tests/Templates/StandardTemplate/StandardTemplate.json
+++ /dev/null
@@ -1,4 +0,0 @@
-{
-  "DisplayName": "Standard Template",
-  "Description": "Standard template without any logo."
-}
\ No newline at end of file
diff --git a/tests/MoBi.Tests/Templates/StandardTemplate/StandardTemplate.tex b/tests/MoBi.Tests/Templates/StandardTemplate/StandardTemplate.tex
deleted file mode 100644
index 6c9f3ca88..000000000
--- a/tests/MoBi.Tests/Templates/StandardTemplate/StandardTemplate.tex
+++ /dev/null
@@ -1,41 +0,0 @@
-\documentclass[a4paper, titlepage, oneside]{report}
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diff --git a/tests/MoBi.Tests/TestFiles/331_TestGI.mbp3 b/tests/MoBi.Tests/TestFiles/331_TestGI.mbp3
deleted file mode 100644
index e656da6af..000000000
Binary files a/tests/MoBi.Tests/TestFiles/331_TestGI.mbp3 and /dev/null differ
diff --git a/tests/MoBi.Tests/TestFiles/523_Export_S1.pkml b/tests/MoBi.Tests/TestFiles/523_Export_S1.pkml
deleted file mode 100644
index 687d352be..000000000
--- a/tests/MoBi.Tests/TestFiles/523_Export_S1.pkml
+++ /dev/null
@@ -1,41319 +0,0 @@
-<?xml version="1.0" encoding="utf-8"?>
-<SimulationTransfer version="3">
-  <Simulation id="2TD4FTdlBkOVvx3M8nzQng" name="S1" parameterIdetificationWorkingDirectory="test">
-    <BuildConfiguration>
-      <Molecules id="Zfzv84-nK0KwsZ1OblVW4g" name="S1" bbVersion="0">
-        <Builders>
-          <MoleculeBuilder id="ElzX3nTi5EaLs-9BhrwtRQ" name="C1" icon="Drug" mode="Logical" containerType="Other" isFloating="1" quantityType="Drug" isXenobiotic="1" defaultStartFormula="npvUwCRrEk6fvvfOPA8xNw">
-            <Children>
-              <Parameter id="nVR382oNAky9EZcXw7mVWQ" name="pKa_TwoAcids_0" description="Smallest acid pKa for compound with 2 acid groups" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_TwoAcids_0" buildMode="Property" visible="0" canBeVaried="0" />
-              <Parameter id="FqzC6WUM5EiU9nwpzqXK7Q" name="pKa_pH_WS_sol_K2" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_K2" buildMode="Property" visible="0" canBeVaried="0" />
-              <Parameter id="UvfWCWHYI0eyNrRoIS2YXQ" name="pKa_pH_WS_sol_K3" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_K3" buildMode="Property" visible="0" canBeVaried="0" />
-              <Parameter id="yY1_amPMMkyg0VqwUK7bFw" name="pKa_pH_WS_sol_K4" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_K4" buildMode="Property" visible="0" canBeVaried="0" />
-              <Parameter id="82Yn63QUJ0OLJtfqp1BBOw" name="pKa_pH_WS_sol_K5" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_K5" buildMode="Property" visible="0" canBeVaried="0" />
-              <Parameter id="Bqu3DhHkwEqe3N6Fq7j--g" name="pKa_pH_WS_sol_K6" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_K6" buildMode="Property" visible="0" canBeVaried="0" />
-              <Parameter id="RWqknSlTBUW1_CyWuU9s5Q" name="pKa_pH_WS_sol_K7" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_K7" buildMode="Property" visible="0" canBeVaried="0" />
-              <Parameter id="xeK3uQDhe0eacYStN8okzw" name="pKa_pH_WS_sol_K8" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_K8" buildMode="Property" visible="0" canBeVaried="0" />
-              <Parameter id="ozuLsbLzmEKco4V23ZMMNg" name="pKa_ThreeAcids_0" description="Smallest acid pKa for compound with 3 acid groups" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_ThreeAcids_0" buildMode="Property" visible="0" canBeVaried="0" />
-              <Parameter id="0Yo5AWZpQkO__or00s45YA" name="pKa_ThreeAcids_1" description="Middle acid pKa for compound with 3 acid groups" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_ThreeAcids_1" buildMode="Property" visible="0" canBeVaried="0" />
-              <Parameter id="9ZVDl_KCQUy30sK_emGLZg" name="pKa_ThreeBases_1" description="Middle base pKa for compound with 3 base groups" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_ThreeBases_1" buildMode="Property" visible="0" canBeVaried="0" />
-              <Parameter id="JmdxQLZdT0-4ke8zdfwzSw" name="Total oral drug mass" description="Total oral drug mass" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" buildMode="Property" visible="0" canBeVaried="0" value="0" displayUnit="µmol" />
-              <Parameter id="UJFFX1yhEEKigxotxlD90w" name="pKa_TwoAcids_1" description="Middle acid pKa for compound with 2 acid groups" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_TwoAcids_1" buildMode="Property" visible="0" canBeVaried="0" />
-              <Parameter id="MnVWQqYRi0KIWRTwc9xNvA" name="pKa_TwoBases_0" description="Smallest base pKa for compound with 2 base groups" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_TwoBases_0" buildMode="Property" visible="0" canBeVaried="0" />
-              <Parameter id="1vmlXAkG90mcV_CSKWCXFA" name="pKa_TwoBases_1" description="Middle base pKa for compound with 2 base groups" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_TwoBases_1" buildMode="Property" visible="0" canBeVaried="0" />
-              <Parameter id="j10DYfg2aECQhcjbVflVVA" name="Plasma protein binding partner" description="Plasma protein to which the drug is predominantly bound. The ontogeny of the two most important plasma protein binding partners, albumin and α1-acid glycoprotein (AGP) is available in the PK-Sim database so that the fraction unbound in plasma can be scaled to children using the ontogeny of the respective protein. If  the binding partner is neither albumin nor AGP  or if scaling to children is not of interest, the third alternative (unknown) can be used. Please note that any other ontogeny can be uploaded for the scaling to children using the Population Simulation Toolbox in MoBi" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="0" value="1" />
-              <Parameter id="L2JGriQRWUmsNoePX4t0ow" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_RefpH_Factor" buildMode="Property" visible="0" canBeVaried="0" />
-              <Parameter id="x5Rck4aJVUmnrZYficu1mg" name="pKa_ThreeBases_0" description="Smallest base pKa for compound with 3 base groups" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_ThreeBases_0" buildMode="Property" visible="0" canBeVaried="0" />
-              <Parameter id="gnqe24JiL0u3KYXdCwdHJw" name="pKa_Base_1" description="Middle base pKa" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_Base_1" buildMode="Property" visible="0" canBeVaried="0" />
-              <Parameter id="n9wnTqW7JE2rmCPeMZO_rw" name="pKa_Bases_Count" description="Number of basic groups in compound" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_Bases_Count" buildMode="Property" visible="0" canBeVaried="0" />
-              <Parameter id="826veRLV9ESxP5sYPwJuyA" name="base_For_KaPL_Factor" description="Supporting parameter for calculation of pKa- and pH- dependent values of KaPL" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="0" canBeVaried="0" value="20" />
-              <Parameter id="8BJpqEA3cEaq4FQzsVS-hA" name="base_For_logD_Factor" description="Supporting parameter for calculation of pKa- and pH- dependent logD" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="0" canBeVaried="0" value="0.001" />
-              <Parameter id="jp_BcJJ5R0WCzbVnaUmJzQ" name="base_For_P_cell_Factor" description="Supporting parameter for calculation of pKa- and pH- dependent permeability to/from cells" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="0" canBeVaried="0" value="0.001" />
-              <Parameter id="NV8PJR-dEk6hIIETPHlrHA" name="BP_ALBUMIN" description="Constant for binding partner albumin" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="0" canBeVaried="0" value="1" />
-              <Parameter id="k8VA3KtmXkSEu5LXF2VmxQ" name="pKa value 2" description="pKa value" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="1" value="0" />
-              <Parameter id="kU4A58M59EuGxlikjU5glg" name="base_For_Pint_Factor" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="0" canBeVaried="0" value="0.1" />
-              <Parameter id="QeAe4mjrOEmF4YHLrOUCqg" name="Is strong base" description="Supporting parameter for partition coeffs in RR-Modell (at least one basic pKa&gt;=7)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_HasStrongBase" buildMode="Property" visible="0" canBeVaried="0" />
-              <Parameter id="XqXq1boyM0CUn8ozoNvFvg" name="Is triprotic acid" description="Is triprotic acid" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_IsTriproticAcid" buildMode="Property" visible="0" canBeVaried="0" />
-              <Parameter id="-udx0HDAhkOUztJOu1sw7Q" name="Is triprotic base" description="Is triprotic base" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_IsTriproticBase" buildMode="Property" visible="0" canBeVaried="0" />
-              <Parameter id="nMJWtMULGUuCv4Ci8rFufw" name="Molecular weight" description="Molecular weight" persistable="0" isFixedValue="0" dim="Molecular weight" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="1" value="4E-07" displayUnit="g/mol" />
-              <Parameter id="M-aHOxU5LECQnbyy8VeF6g" name="Is neutral" description="Supporting parameter for partition coeffs in RR-Modell" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_IsNeutral" buildMode="Property" visible="0" canBeVaried="0" />
-              <Parameter id="Vk_1D6ZeVUmLDz3bBe6mRA" name="pKa value 1" description="pKa value" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="1" value="0" />
-              <Parameter id="LnRFb3l1Q0Wdob36-owclw" name="Is monoprotic base monoprotic acid" description="Is monoprotic base monoprotic acid" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_IsMonoproticBaseMonoproticAcid" buildMode="Property" visible="0" canBeVaried="0" />
-              <Parameter id="jiXbZ1zRLEyU5w6gWCJK8g" name="pKa_Acid_0" description="Smallest acid pKa" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_Acid_0" buildMode="Property" visible="0" canBeVaried="0" />
-              <Parameter id="KJk2A3W7QE6iL0x9TtjcUA" name="pKa_Acid_1" description="Middle acid pKa" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_Acid_1" buildMode="Property" visible="0" canBeVaried="0" />
-              <Parameter id="idhYVT6u_k-Wzql3W3iqdQ" name="pKa_Acid_2" description="Largest acid pKa" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_Acid_2" buildMode="Property" visible="0" canBeVaried="0" />
-              <Parameter id="V3X9e2aep0uPd7i9SgEqww" name="pKa_Acids_Count" description="Number of acidic groups in compound" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_Acids_Count" buildMode="Property" visible="0" canBeVaried="0" />
-              <Parameter id="_k8KEN_0_kGUEEpENsuhMA" name="pKa_Base_0" description="Smallest base pKa" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_Base_0" buildMode="Property" visible="0" canBeVaried="0" />
-              <Parameter id="QFcHEU8TvkObesSkntRStQ" name="pKa_Base_2" description="Largest base pKa" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_Base_2" buildMode="Property" visible="0" canBeVaried="0" />
-              <Parameter id="DSf9umXY6US8znlVVMFQmA" name="pKa_OneAcid_0" description="Smallest acid pKa for compound with 1 acid group" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_OneAcid_0" buildMode="Property" visible="0" canBeVaried="0" />
-              <Parameter id="bVT90rwR-0aCmtAffDzspA" name="pKa_OneBase_0" description="Smallest base pKa for compound with 1 base group" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_OneBase_0" buildMode="Property" visible="0" canBeVaried="0" />
-              <Parameter id="h1eWOtwd00e6hDiAbcmHQQ" name="pKa_pH_WS_sol_F1" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_F1" buildMode="Property" visible="0" canBeVaried="0" />
-              <Parameter id="Y1n2tj5MIEWDNk8HEPw0Bg" name="pKa_pH_WS_sol_F2" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_F2" buildMode="Property" visible="0" canBeVaried="0" />
-              <Parameter id="ywFw5QpGNkaJl5BwvQuBGw" name="pKa_pH_WS_sol_F3" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_F3" buildMode="Property" visible="0" canBeVaried="0" />
-              <Parameter id="CI6UQXgzQEyW2RIgOX7wSA" name="pKa value 0" description="pKa value" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="1" value="0" />
-              <Parameter id="AGHsmIM6yUWv4--imKXKGA" name="Effective molecular weight" description="Effective molecular weight" persistable="0" isFixedValue="0" dim="Molecular weight" quantityType="Parameter" formula="CompoundMW_PKSim.PARAM_MWEff" buildMode="Property" visible="1" canBeVaried="0" displayUnit="g/mol" />
-              <Parameter id="G9GoxBKBX0CAdsoSf0y3FQ" name="pKa_pH_WS_sol_K1" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_K1" buildMode="Property" visible="0" canBeVaried="0" />
-              <Parameter id="DNRNd5PvbEC077EWWlwf6w" name="BP_UNKNOWN" description="Constant for binding partner unknown" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="0" canBeVaried="0" value="2" />
-              <Parameter id="3g-jSE1b_0qdGT0-zz9o6Q" name="Br" description="Number of bromine atoms in molecule" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="0" value="0" />
-              <Parameter id="N-BczFAGOkeESnmIDBWjPw" name="Calculated specific intestinal permeability (transcellular)" description="Calculated specific intestinal permeability (transcellular)" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_InVitro" buildMode="Global" visible="0" canBeVaried="0" displayUnit="cm/min" />
-              <Parameter id="ct_xIGQUQkGkBaC5QgHzGA" name="Cl" description="Number of chlorine atoms in molecule" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="0" value="0" />
-              <Parameter id="zoqsXHr-KkWqA5WIzb5yCg" name="Compound type 0" description="Compound type (-1: acid, +1: base, 0: neutral)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="0" value="0" />
-              <Parameter id="oTPfHVqN_EWUvCNl5svegQ" name="Compound type 1" description="Compound type (-1: acid, +1: base, 0: neutral)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="0" value="0" />
-              <Parameter id="SRhRE5bK2UKoGOslqP913Q" name="Compound type 2" description="Compound type (-1: acid, +1: base, 0: neutral)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="0" value="0" />
-              <Parameter id="odobRLnDtU-PtAC8uTsnMQ" name="CT_ACID" description="Constant for compound type acid" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="0" canBeVaried="0" value="-1" />
-              <Parameter id="7NsIPbUOoU6sTlUqCFOi2w" name="CT_BASE" description="Constant for compound type base" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="0" canBeVaried="0" value="1" />
-              <Parameter id="AEY0ZEbnM0mwe5c-NLk-hQ" name="Is small molecule" description="Treat compound as small molecule or not (if not, both organ specific and intestinal permeability will be set to zero)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="0" canBeVaried="0" value="1" />
-              <Parameter id="eL9j_tIee0OTbgcPMmItpg" name="BP_AGP" description="Constant for binding partner α1-acid glycoprotein" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="0" canBeVaried="0" value="0" />
-              <Parameter id="AvjS2jLDH0OaYTnsUPwWRA" name="F" description="Number of fluorine atoms in molecule" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="0" value="0" />
-              <Parameter id="ElNZymOMPUCKMnWt_Kxwgw" name="Has halogens" description="Supporting parameter for compound" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundMW_PKSim.PARAM_HasHalogens" buildMode="Property" visible="0" canBeVaried="0" />
-              <Parameter id="-49Hq_GS7Eq6pDovtpcofg" name="I" description="Number of iodine atoms in molecule" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="0" value="0" />
-              <Parameter id="8kW90BOCUESKgtOriFxaeA" name="Is diprotic acid" description="Is diprotic acid" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_IsDiproticAcid" buildMode="Property" visible="0" canBeVaried="0" />
-              <Parameter id="9CKaK7reVkeL00AkmJ-94w" name="Is diprotic base" description="Is diprotic base" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_IsDiproticBase" buildMode="Property" visible="0" canBeVaried="0" />
-              <Parameter id="RhSe1hCeDUe3FYJeAR6p5Q" name="Is diprotic base monoprotic acid" description="Is diprotic base monoprotic acid" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_IsDiproticBaseMonoproticAcid" buildMode="Property" visible="0" canBeVaried="0" />
-              <Parameter id="ZzzcYMnjGkO-u0ZvJ1c5CQ" name="Is floating in lumen" description="Is floating in lumen" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="0" canBeVaried="0" value="1" />
-              <Parameter id="SWMdA8LmxkqkEo6JAD0_BQ" name="Is monoprotic acid" description="Is monoprotic acid" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_IsMonoproticAcid" buildMode="Property" visible="0" canBeVaried="0" />
-              <Parameter id="yGs1ItV5xUS8qWLIvmL4yA" name="Is monoprotic base" description="Is monoprotic base" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_IsMonoproticBase" buildMode="Property" visible="0" canBeVaried="0" />
-              <Parameter id="ybNEVSGwUkmYITpmAT6ceQ" name="Is monoprotic base diprotic acid" description="Is monoprotic base diprotic acid" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_IsMonoproticBaseDiproticAcid" buildMode="Property" visible="0" canBeVaried="0" />
-              <Parameter id="5iUMJux-fU-0mwpK2EJYGQ" name="CT_NEUTRAL" description="Constant for compound type neutral" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="0" canBeVaried="0" value="0" />
-              <Parameter id="XHY79l31GEGJWLQwwynKOg" name="Lipophilicity" description="Model dependent lipophilicity measure: LogMA / LogP / ..." persistable="0" isFixedValue="0" dim="Log Units" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="1" value="3" displayUnit="Log Units" />
-              <Parameter id="qTs5l6MHuUWrPqhRbf3UXg" name="Fraction unbound (plasma, reference value)" description="Fraction unbound in plasma of the reference individual, i.e. in the case of human typically an average healthy adult. This reference value can be scaled to children based on the ontogeny of the respective plasma protein and/or in diseased subjects using the plasma protein scale factor defined in the individual" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="1" value="0.11" />
-              <Parameter id="uh2bp2PeyUWjhgox1CXiWw" name="Solubility at reference pH" description="Solubility at reference pH" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="1" value="1.2E-05" displayUnit="mg/l" />
-              <Parameter id="-gUBeFROlECO_mKXcNi9DA" name="Reference pH" description="Reference pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="1" value="7" />
-              <Parameter id="N8GV3kaNVEC36627mey0mA" name="Solubility gain per charge" description="Supporting parameter for calculation of pKa- and pH- dependent values of intestinal solubilty" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="0" value="1000" />
-              <Parameter id="WDu5ixtj2UmyMQ3giYzQug" name="Permeability" description="Permeability" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_P" buildMode="Property" visible="1" canBeVaried="1" displayUnit="cm/min" />
-              <Parameter id="7rLTdh8iakSRF64PWH7I5Q" name="Specific intestinal permeability (transcellular)" description="Specific intestinal permeability (transcellular)" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_InVitro" buildMode="Property" visible="1" canBeVaried="1" displayUnit="cm/min" />
-              <Parameter id="EbNmqMWvm0y2hWBaj1lVHA" name="Partition coefficient (water/protein)" description="Partition coefficient water to protein" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionInVitro_PKSim.PARAM_KProt" buildMode="Property" visible="1" canBeVaried="1" />
-              <Parameter id="efndwNgCLEm9Fb8oIvrfiQ" name="Treat precipitated drug as" description="Treat precipitated drug as either soluble or insoluble" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="1" value="1" />
-              <Parameter id="4gGzHYEtokq-ZG48qCm-iA" name="Aqueous diffusion coefficient" description="Aqueous diffusion coefficient&#xA;of the drug" persistable="0" isFixedValue="0" dim="Diffusion coefficient" quantityType="Parameter" formula="CompoundCommon.PARAM_Aqueous_diffusion_coefficient" buildMode="Property" visible="1" canBeVaried="1" displayUnit="cm²/min" />
-              <Parameter id="vDD9t_kiu0yeweRkrpA9ag" name="Density (drug)" description="Density of drug material" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="1" value="1" displayUnit="g/cm³" />
-              <Parameter id="wdI8I-pYV0KLhpAszsPVig" name="Immediately dissolve particles smaller than" description="Threshold for the particle radius of immediate dissolution" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="1" value="1E-07" displayUnit="µm" />
-              <Parameter id="IIWTulndYEW76LuQ512ZNA" name="Radius (solute)" description="Solute radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="CompoundCommon.PARAM_Ae" buildMode="Property" visible="1" canBeVaried="1" displayUnit="µm" />
-              <Parameter id="oXkyQIxAM0qHk6Q9m2HBQQ" name="Kd (FcRn) in endosomal space" description="Dissociation constant of drug for binding to FcRn in endosomal space" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="0" value="999999" displayUnit="µmol/l" />
-              <Parameter id="OskmEv7jE026Q7ams_Npbw" name="Kd (FcRn) in plasma/interstitial" description="Dissociation constant of drug for binding to FcRn in plasma/interstitial space. For monoclonal antibodies the binding to FcRn in neutral environment (plasma and interstitial space) is generally very weak or not detectable. In this case the high default value for Kd(FcRn) in plasma/interstitial can be kept." persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="0" value="999999" displayUnit="µmol/l" />
-              <Parameter id="3nG-WVwx8UaDRY8uVTLl8Q" name="kass (FcRn)" description="Association constant of drug for binding to FcRn" persistable="0" isFixedValue="0" dim="Second order rate constant" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="0" value="60" displayUnit="l/µmol/min" />
-              <Parameter id="XwNtnab1bUmCUc2hc9Sxkw" name="Use pH- and pKa-dependent penalty factor for charged molecule fraction" description="Penalty factor for charged molecule fraction is used for &quot;Intestinal permeability (transcellular)&quot; only" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="1" value="0" />
-              <Parameter id="WuoIu1euP0qT9-GMbTXH4g" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="ConcFormula" visible="0" canBeVaried="0" />
-            </Children>
-            <UsedCalculationMethods>
-              <UsedCalculationMethod category="DistributionCellular" calculationMethod="Cellular partition coefficient method - PK-Sim Standard" />
-              <UsedCalculationMethod category="DiffusionIntCell" calculationMethod="Cellular permeability - PK-Sim Standard" />
-              <UsedCalculationMethod category="DistributionInterstitial" calculationMethod="Interstitial partition coefficient method - Schmitt" />
-            </UsedCalculationMethods>
-          </MoleculeBuilder>
-        </Builders>
-        <FormulaCache>
-          <Formulas>
-            <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_TwoAcids_0" name="PARAM_pKa_TwoAcids_0" dim="Dimensionless" formula="pKa_Acids_Count=2 ? (CT0 != CT_ACID ? Min(pKa_1;pKa_2) : (CT1 != CT_ACID ? Min(pKa_0;pKa_2) : Min(pKa_0;pKa_1))) : 0">
-              <Paths>
-                <Path path="0" as="1" />
-                <Path path="2" as="3" />
-                <Path path="4" as="5" />
-                <Path path="6" as="7" />
-                <Path path="8" as="9" />
-                <Path path="10" as="11" />
-                <Path path="12" as="13" />
-              </Paths>
-            </Formula>
-            <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_K2" name="PARAM_pKa_pH_WS_sol_K2" dim="Dimensionless" formula="(1-F1)*F2*F3">
-              <Paths>
-                <Path path="14" as="15" />
-                <Path path="16" as="17" />
-                <Path path="18" as="19" />
-              </Paths>
-            </Formula>
-            <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_K3" name="PARAM_pKa_pH_WS_sol_K3" dim="Dimensionless" formula="F1*(1-F2)*F3">
-              <Paths>
-                <Path path="14" as="15" />
-                <Path path="16" as="17" />
-                <Path path="18" as="19" />
-              </Paths>
-            </Formula>
-            <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_K4" name="PARAM_pKa_pH_WS_sol_K4" dim="Dimensionless" formula="F1*F2*(1-F3)">
-              <Paths>
-                <Path path="14" as="15" />
-                <Path path="16" as="17" />
-                <Path path="18" as="19" />
-              </Paths>
-            </Formula>
-            <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_K5" name="PARAM_pKa_pH_WS_sol_K5" dim="Dimensionless" formula="(1-F1)*(1-F2)*F3">
-              <Paths>
-                <Path path="14" as="15" />
-                <Path path="16" as="17" />
-                <Path path="18" as="19" />
-              </Paths>
-            </Formula>
-            <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_K6" name="PARAM_pKa_pH_WS_sol_K6" dim="Dimensionless" formula="(1-F1)*F2*(1-F3)">
-              <Paths>
-                <Path path="14" as="15" />
-                <Path path="16" as="17" />
-                <Path path="18" as="19" />
-              </Paths>
-            </Formula>
-            <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_K7" name="PARAM_pKa_pH_WS_sol_K7" dim="Dimensionless" formula="F1*(1-F2)*(1-F3)">
-              <Paths>
-                <Path path="14" as="15" />
-                <Path path="16" as="17" />
-                <Path path="18" as="19" />
-              </Paths>
-            </Formula>
-            <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_K8" name="PARAM_pKa_pH_WS_sol_K8" dim="Dimensionless" formula="(1-F1)*(1-F2)*(1-F3)">
-              <Paths>
-                <Path path="14" as="15" />
-                <Path path="16" as="17" />
-                <Path path="18" as="19" />
-              </Paths>
-            </Formula>
-            <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_ThreeAcids_0" name="PARAM_pKa_ThreeAcids_0" dim="Dimensionless" formula="IsTriproticAcid ? Min (pKa_0; Min (pKa_1; pKa_2)) : 0">
-              <Paths>
-                <Path path="20" as="21" />
-                <Path path="6" as="7" />
-                <Path path="8" as="9" />
-                <Path path="10" as="11" />
-              </Paths>
-            </Formula>
-            <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_ThreeAcids_1" name="PARAM_pKa_ThreeAcids_1" dim="Dimensionless" formula="IsTriproticAcid ? (pKa_0 &lt;= pKa_Acid_0 ? min(pKa_1; pKa_2) : (pKa_0 &gt;= pKa_Acid_2 ? max(pKa_1; pKa_2) : pKa_0)) : 0">
-              <Paths>
-                <Path path="20" as="21" />
-                <Path path="6" as="7" />
-                <Path path="8" as="9" />
-                <Path path="10" as="11" />
-                <Path path="22" as="23" />
-                <Path path="24" as="25" />
-              </Paths>
-            </Formula>
-            <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_ThreeBases_1" name="PARAM_pKa_ThreeBases_1" dim="Dimensionless" formula="IsTriproticBase ? (pKa_0 &lt;= pKa_Base_0 ? min(pKa_1; pKa_2) : (pKa_0 &gt;= pKa_Base_2 ? max(pKa_1; pKa_2) : pKa_0)) : 0">
-              <Paths>
-                <Path path="26" as="27" />
-                <Path path="6" as="7" />
-                <Path path="8" as="9" />
-                <Path path="10" as="11" />
-                <Path path="28" as="29" />
-                <Path path="30" as="31" />
-              </Paths>
-            </Formula>
-            <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_TwoAcids_1" name="PARAM_pKa_TwoAcids_1" dim="Dimensionless" formula="pKa_Acids_Count=2 ? (CT0 != CT_ACID ? Max(pKa_1;pKa_2) : (CT1 != CT_ACID ? Max(pKa_0;pKa_2) : Max(pKa_0;pKa_1))) : 0">
-              <Paths>
-                <Path path="0" as="1" />
-                <Path path="2" as="3" />
-                <Path path="4" as="5" />
-                <Path path="6" as="7" />
-                <Path path="8" as="9" />
-                <Path path="10" as="11" />
-                <Path path="12" as="13" />
-              </Paths>
-            </Formula>
-            <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_TwoBases_0" name="PARAM_pKa_TwoBases_0" dim="Dimensionless" formula="pKa_Bases_Count=2 ? (CT0 != CT_BASE ? Min(pKa_1;pKa_2) : (CT1 != CT_BASE ? Min(pKa_0;pKa_2) : Min(pKa_0;pKa_1))) : 0">
-              <Paths>
-                <Path path="0" as="1" />
-                <Path path="2" as="3" />
-                <Path path="32" as="33" />
-                <Path path="6" as="7" />
-                <Path path="8" as="9" />
-                <Path path="10" as="11" />
-                <Path path="34" as="35" />
-              </Paths>
-            </Formula>
-            <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_TwoBases_1" name="PARAM_pKa_TwoBases_1" dim="Dimensionless" formula="pKa_Bases_Count=2 ? (CT0 != CT_BASE ? Max(pKa_1;pKa_2) : (CT1 != CT_BASE ? Max(pKa_0;pKa_2) : Max(pKa_0;pKa_1))) : 0">
-              <Paths>
-                <Path path="0" as="1" />
-                <Path path="2" as="3" />
-                <Path path="32" as="33" />
-                <Path path="6" as="7" />
-                <Path path="8" as="9" />
-                <Path path="10" as="11" />
-                <Path path="34" as="35" />
-              </Paths>
-            </Formula>
-            <Formula id="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_RefpH_Factor" name="PARAM_Solubility_pKa_RefpH_Factor" dim="Dimensionless" formula="K1+K2/base^(CT0^2)+K3/base^(CT1^2)+K4/base^(CT2^2)+K5/base^max(CT0+CT1;-CT0-CT1)+K6/base^max(CT0+CT2;-CT0-CT2)+K7/base^max(CT1+CT2;-CT1-CT2)+K8/base^max(CT0+CT1+CT2;-CT0-CT1-CT2)">
-              <Paths>
-                <Path path="0" as="1" />
-                <Path path="2" as="3" />
-                <Path path="36" as="37" />
-                <Path path="38" as="39" />
-                <Path path="40" as="41" />
-                <Path path="42" as="43" />
-                <Path path="44" as="45" />
-                <Path path="46" as="47" />
-                <Path path="48" as="49" />
-                <Path path="50" as="51" />
-                <Path path="52" as="53" />
-                <Path path="54" as="55" />
-              </Paths>
-            </Formula>
-            <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_ThreeBases_0" name="PARAM_pKa_ThreeBases_0" dim="Dimensionless" formula="IsTriproticBase ? Min (pKa_0; Min (pKa_1; pKa_2)) : 0">
-              <Paths>
-                <Path path="26" as="27" />
-                <Path path="6" as="7" />
-                <Path path="8" as="9" />
-                <Path path="10" as="11" />
-              </Paths>
-            </Formula>
-            <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_Base_1" name="PARAM_pKa_Base_1" dim="Dimensionless" formula="pKa_TwoBases_1+pKa_ThreeBases_1">
-              <Paths>
-                <Path path="56" as="57" />
-                <Path path="58" as="59" />
-              </Paths>
-            </Formula>
-            <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_Bases_Count" name="PARAM_pKa_Bases_Count" dim="Dimensionless" formula="(CT0 = CT_BASE ? 1 : 0) + (CT1 = CT_BASE ? 1 : 0) + (CT2 = CT_BASE ? 1 : 0)">
-              <Paths>
-                <Path path="0" as="1" />
-                <Path path="2" as="3" />
-                <Path path="36" as="37" />
-                <Path path="32" as="33" />
-              </Paths>
-            </Formula>
-            <Formula id="CompoundAcidBase_PKSim.PARAM_HasStrongBase" name="PARAM_HasStrongBase" dim="Dimensionless" formula="(CT_0=1 AND pKa_0&gt;=7) OR (CT_1=1 AND pKa_1&gt;=7) OR (CT_2=1 AND pKa_2&gt;=7)">
-              <Paths>
-                <Path path="0" as="60" />
-                <Path path="2" as="61" />
-                <Path path="36" as="62" />
-                <Path path="6" as="7" />
-                <Path path="8" as="9" />
-                <Path path="10" as="11" />
-              </Paths>
-            </Formula>
-            <Formula id="CompoundAcidBase_PKSim.PARAM_IsTriproticAcid" name="PARAM_IsTriproticAcid" dim="Dimensionless" formula="pKa_Acids_Count=3 &amp; pKa_Bases_Count = 0 ? 1 : 0">
-              <Paths>
-                <Path path="12" as="13" />
-                <Path path="34" as="35" />
-              </Paths>
-            </Formula>
-            <Formula id="CompoundAcidBase_PKSim.PARAM_IsTriproticBase" name="PARAM_IsTriproticBase" dim="Dimensionless" formula="pKa_Acids_Count=0 &amp; pKa_Bases_Count = 3 ? 1 : 0">
-              <Paths>
-                <Path path="12" as="13" />
-                <Path path="34" as="35" />
-              </Paths>
-            </Formula>
-            <Formula id="CompoundAcidBase_PKSim.PARAM_IsNeutral" name="PARAM_IsNeutral" dim="Dimensionless" formula="CT_0 = 0 AND CT_1 = 0 AND CT_2 = 0">
-              <Paths>
-                <Path path="0" as="60" />
-                <Path path="2" as="61" />
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-                      <Parameter id="3ulv6JckEkGubFnduoM0pA" name="Tablet time delay factor" description="Tablet time delay factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.2" />
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-                      <Parameter id="arrF5OJSJ0qg0kJWdVk1aQ" name="Tablet_Location_cae" description="Tablet location in Cecum" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BLVaeT1Z8EaDaGKBKDsQoQ" visible="0" canBeVaried="0" />
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-                      <Parameter id="owCxv6B0lk6-4j81hQCuRg" name="Tablet_Location_colasc" description="Tablet location in Colon Ascendens" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="EjUbnPsYEk-XZ5hW3OYdaA" visible="0" canBeVaried="0" />
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-                      <Parameter id="MXMTpuP3bUKYPD9eBYjx5Q" name="Tablet_Location_colsigm" description="Tablet location in Colon Sigmoid" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="3PD9tWoLY0q2v3ekNvhFpg" visible="0" canBeVaried="0" />
-                      <Parameter id="r0qbLnYFSUOk0TA-FHPgPw" name="Tablet_Location_coldesc" description="Tablet location in Colon Descendens" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="nYVUeXChU0ermVWFPiKMxA" visible="0" canBeVaried="0" />
-                      <Parameter id="G6mo3ZfFDUaAXuGuFtyFNQ" name="Tablet_Location" description="Tablet location in lumen" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="0" rHSFormula="UDkPHOp750Sk2Kd-KH7f8w" value="1.99" />
-                      <Parameter id="wDc3lrfwX0CKhHQhuvO4_g" name="TabletIsActive" description="Enables/disables all tablet interactions" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="0" value="0" />
-                      <Parameter id="EFsnU9lptUWyCrfw-fKFVg" name="Tablet_Location_uje" description="Tablet location in Upper Jejunum" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="cfyjeV6_fUGZWtxkliWtTA" visible="0" canBeVaried="0" />
-                      <EventBuilder id="v2KN4FycPEa9nepWYmiDlQ" name="Application_StartEvent" description="Start event for application" oneTime="1" dimension="Dimensionless" formula="5Zv4IhCylUaq3nk6LvfTJw">
-                        <Tags>
-                          <Tag value="Application" />
-                          <Tag value="Application_1" />
-                        </Tags>
-                        <Assignments>
-                          <EventAssignmentBuilder id="AIKRkTfu30i1sFDwyycIoQ" name="Assignment_1" useAsValue="1" dimension="Amount" formula="4Tn1NKPO9kyZUg0y9tDS7A">
-                            <ObjectPath path="0" />
-                          </EventAssignmentBuilder>
-                          <EventAssignmentBuilder id="VsFhDBSzZEOiI2e-xpsr2g" name="Assignment_2" useAsValue="1" dimension="Dimensionless" formula="AnOkAR9YLEeLUV0Lb-7yBA">
-                            <ObjectPath path="1" />
-                          </EventAssignmentBuilder>
-                          <EventAssignmentBuilder id="B6JsXnthj0mNbP5aVi8nRw" name="Assignment_3" useAsValue="1" dimension="Dimensionless" formula="xHLC8PU0jUCwvOxPkQRnKQ">
-                            <ObjectPath path="2" />
-                          </EventAssignmentBuilder>
-                          <EventAssignmentBuilder id="hrgry0kmE0K5MMnQhooV7A" name="Assignment_4" useAsValue="1" dimension="Volume" formula="iX6mR0PzmEKNWG7NBcmAfQ">
-                            <ObjectPath path="3" />
-                          </EventAssignmentBuilder>
-                        </Assignments>
-                      </EventBuilder>
-                      <EventBuilder id="RkuR4LgDWke5fZ9m2uS8Wg" name="Application_StopEvent" description="Stop event for application" oneTime="1" dimension="Dimensionless" formula="YT6_UGZnYUC8lbFg99mh2A">
-                        <Tags>
-                          <Tag value="Application" />
-                          <Tag value="Application_1" />
-                        </Tags>
-                        <Assignments>
-                          <EventAssignmentBuilder id="28IK4Hek5Uu6DaNNBdmaKg" name="Assignment_1" useAsValue="0" dimension="Dimensionless" formula="7LLMfNQaKUmS_HAsJxjMMQ">
-                            <ObjectPath path="1" />
-                          </EventAssignmentBuilder>
-                        </Assignments>
-                      </EventBuilder>
-                      <Container id="DX1ldv8XqUqOYtQhV-ok4A" name="ProtocolSchemaItem" description="Protocol Schema Item" mode="Logical" containerType="Other">
-                        <Tags>
-                          <Tag value="Application" />
-                          <Tag value="Application_1" />
-                        </Tags>
-                        <Children>
-                          <Parameter id="1zj11D6VAkaIYgT3Jfa81w" name="Start time" description="Start time of application" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" visible="1" canBeVaried="1" value="0" displayUnit="h" />
-                          <Parameter id="-ArJHGTM7Umk1ebXHx0KtA" name="DosePerBodyWeight" description="Dose" persistable="0" isFixedValue="0" dim="Dose per body weight" quantityType="Parameter" visible="1" canBeVaried="1" value="1E-06" displayUnit="mg/kg" />
-                          <Parameter id="EYP8swob7U2U1IAzWSm8fg" name="DrugMass" description="Drug mass of application" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" formula="aFEcqAV6nEOfzVOTRfs8Bg" visible="0" canBeVaried="1" displayUnit="µmol" />
-                          <Parameter id="1QX0EgEXxkeFXTGflf960Q" name="Dose" description="Dose" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="7KxL5YlgvEGOd6HUnFJcFQ" visible="0" canBeVaried="1" displayUnit="mg" />
-                          <Parameter id="MrF25lZfo0qFyb78fakq1w" name="Volume of water/body weight" description="Volume of water per body weight co-administered with the drug" persistable="0" isFixedValue="0" dim="Volume per body weight" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0035" displayUnit="ml/kg" />
-                          <Parameter id="RcZAwmuKJESLYPLorhsg9Q" name="Amount of water" description="Amount of water" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="1D2srxV-OkKtZ_efyJA8IQ" visible="0" canBeVaried="1" displayUnit="l" />
-                        </Children>
-                      </Container>
-                      <EventGroupBuilder id="5UczG7RfFU6cWZgvCtbs3A" name="ParticleBin_1" description="Particle Bin #1" mode="Logical" containerType="Other">
-                        <Tags>
-                          <Tag value="ParticleBin" />
-                          <Tag value="Application" />
-                          <Tag value="Application_1" />
-                        </Tags>
-                        <Children>
-                          <Parameter id="q8Qu5W_pg0iewChVzx8cdQ" name="Number_Of_Particles_Factor" description="Factor for number of particles (depends on particle radius distribution)" persistable="0" isFixedValue="0" dim="Inversed volume" quantityType="Parameter" visible="0" canBeVaried="0" value="238732414637.843" displayUnit="1/l" />
-                          <Parameter id="ScSn42Nm4U-Wufks-uybFA" name="Fraction solid" description="Fraction of solid drug" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" formula="M5_jw_5KB0qF48k1do3h1A" visible="0" canBeVaried="0" />
-                          <Parameter id="m4-vbW5lekS4V3uF_RvSlw" name="Fraction insoluble" description="Fraction of insoluble drug" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" formula="31EEJmL9nEmYF1u6PZxc0A" visible="0" canBeVaried="0" />
-                          <Parameter id="3PL38V3qfkC4IRxStMxoUw" name="Fraction dissolved" description="Fraction of dissolved drug" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" formula="2E8zGNlz7Uyby46M64j4kA" visible="0" canBeVaried="0" />
-                          <Parameter id="1QqZovxzqUWn8znMzgUQtw" name="DrugMass of particle bin" description="Drug mass of a single particle bin" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" formula="BCIc-hCmZ06uWmDcv9Nquw" visible="0" canBeVaried="1" displayUnit="µmol" />
-                          <Parameter id="9icT8WvDaU-CJ3lek5xtYQ" name="Number of particles" description="Number of drug particles in one particle bin" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="MQDEl9Z6rUSXE_c6Fv7aIQ" visible="1" canBeVaried="1" />
-                          <Parameter id="Z3qolRb0D0m5B8zXJZg_nw" name="Particle radius (at t=0)" description="Particle radius at t=0" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0001" displayUnit="µm" />
-                          <Parameter id="2Tv3rBCUgU2VQMUsqbFV3A" name="Particle radius" description="Particle radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="0" value="0" displayUnit="µm" />
-                          <EventBuilder id="dRV2BiIvBkGdoNbctKUBUw" name="ParticleBinDissolvedEvent" description="ParticleBinDissolvedEvent" oneTime="1" dimension="Dimensionless" formula="GdKAJyDASkKWTPihiEU0oQ">
-                            <Tags>
-                              <Tag value="Application" />
-                              <Tag value="Application_1" />
-                            </Tags>
-                            <Assignments>
-                              <EventAssignmentBuilder id="N-E70yTV00yGTWqIxJmQLw" name="Assignment_1" useAsValue="1" dimension="Amount" formula="EUaozAs_m0ui-y2MFQsaVw">
-                                <ObjectPath path="4" />
-                              </EventAssignmentBuilder>
-                              <EventAssignmentBuilder id="NIo1254YO06f5oUY8UEniQ" name="Assignment_2" useAsValue="1" dimension="Amount" formula="ZSu58Oc01U6I7Meb8Cb4FQ">
-                                <ObjectPath path="5" />
-                              </EventAssignmentBuilder>
-                              <EventAssignmentBuilder id="YfZrgoB670u9kvHH1FMeaQ" name="Assignment_3" useAsValue="1" dimension="Amount" formula="R6B38acty0uAYSIr6_HIJw">
-                                <ObjectPath path="6" />
-                              </EventAssignmentBuilder>
-                              <EventAssignmentBuilder id="6cqvPTjUkUm4DbUWZOM_3w" name="Assignment_4" useAsValue="1" dimension="Amount" formula="1AhQ0ZzxIUq6X8PEtQ85nw">
-                                <ObjectPath path="7" />
-                              </EventAssignmentBuilder>
-                              <EventAssignmentBuilder id="ae3VcXTNkk2WYZHWFlc0aQ" name="Assignment_5" useAsValue="1" dimension="Amount" formula="WjzeKBKFwkSBW5rK2QpwFQ">
-                                <ObjectPath path="8" />
-                              </EventAssignmentBuilder>
-                              <EventAssignmentBuilder id="FioDrGTfvUiFe9dAOK-UUA" name="Assignment_6" useAsValue="1" dimension="Amount" formula="Oeh_GVG62U2ZYSSDFfbY-g">
-                                <ObjectPath path="9" />
-                              </EventAssignmentBuilder>
-                              <EventAssignmentBuilder id="dEzKylUumEOnCawddhqaTg" name="Assignment_7" useAsValue="1" dimension="Amount" formula="Pw60ZsJrykOpNjTeatVnow">
-                                <ObjectPath path="10" />
-                              </EventAssignmentBuilder>
-                              <EventAssignmentBuilder id="MnLnWDZGjEmQ5lhzGOFxbw" name="Assignment_8" useAsValue="1" dimension="Amount" formula="qTLW4OYT2EG14ie4wPMjqA">
-                                <ObjectPath path="11" />
-                              </EventAssignmentBuilder>
-                              <EventAssignmentBuilder id="iv5_shKsSkGltZbZYmBaNg" name="Assignment_9" useAsValue="1" dimension="Amount" formula="quKLC_EehUuzNgEj3P0qQw">
-                                <ObjectPath path="12" />
-                              </EventAssignmentBuilder>
-                              <EventAssignmentBuilder id="Ya-fPwV2sEuI4vH_TJsuNg" name="Assignment_10" useAsValue="1" dimension="Amount" formula="6otjFd3ua0OA6G16oImT3w">
-                                <ObjectPath path="13" />
-                              </EventAssignmentBuilder>
-                              <EventAssignmentBuilder id="n9sxbG9U1kypji6dBJaeyg" name="Assignment_11" useAsValue="1" dimension="Amount" formula="GceZW05IbEq4aiNwrfSk8g">
-                                <ObjectPath path="14" />
-                              </EventAssignmentBuilder>
-                              <EventAssignmentBuilder id="eGWIpzI53UyUWtl7DRJHVw" name="Assignment_12" useAsValue="1" dimension="Amount" formula="OwNWwgPhrE2ZPeK6lpxG5g">
-                                <ObjectPath path="15" />
-                              </EventAssignmentBuilder>
-                              <EventAssignmentBuilder id="bLh0vDZLZ06OGaeSAK7vgQ" name="Assignment_13" useAsValue="1" dimension="Dimensionless" formula="H0rjUJgqK0C1XzL8J-rRIA">
-                                <ObjectPath path="16" />
-                              </EventAssignmentBuilder>
-                            </Assignments>
-                          </EventBuilder>
-                          <Container id="J4-06znfDkKWKajCkzNVnw" name="InsolubleDrug" description="Insoluble Drug during particle dissolution" mode="Logical" containerType="Other">
-                            <Tags>
-                              <Tag value="InsolubleDrug" />
-                              <Tag value="Application" />
-                              <Tag value="Application_1" />
-                            </Tags>
-                          </Container>
-                        </Children>
-                        <SourceCriteria />
-                      </EventGroupBuilder>
-                      <ApplicationMoleculeBuilder id="zZX7EmJ8L0K4vHoUiTyt6A" name="ParticleBin_1_soluble" formula="aZozMwF_Rkmet40DUcX4DQ">
-                        <RelativeContainerPath path="17" />
-                      </ApplicationMoleculeBuilder>
-                      <ApplicationMoleculeBuilder id="9H30f4hd5kC1SbHinALF_Q" name="ParticleBin_1_insoluble" formula="FSz8UlUWT0OYY1cQSyBiJg">
-                        <RelativeContainerPath path="18" />
-                      </ApplicationMoleculeBuilder>
-                    </Children>
-                    <SourceCriteria>
-                      <DescriptorConditions>
-                        <MatchTagCondition tag="Applications" />
-                      </DescriptorConditions>
-                    </SourceCriteria>
-                  </ApplicationBuilder>
-                </Children>
-                <SourceCriteria />
-              </EventGroupBuilder>
-              <Parameter id="1_w4axjKIkG0hha6UXvw0g" name="TotalDrugMass" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" formula="uZqeiRhVakCqrb7NOKYxEw" visible="0" canBeVaried="0" displayUnit="µmol" />
-            </Children>
-            <SourceCriteria>
-              <DescriptorConditions>
-                <MatchTagCondition tag="RootContainer" />
-              </DescriptorConditions>
-            </SourceCriteria>
-          </EventGroupBuilder>
-          <EventGroupBuilder id="Jx5-8QxkS0qk6Qt60lFg8Q" name="Fressen" mode="Logical" containerType="Other">
-            <Children>
-              <Parameter id="N7TFSJj9MkeL07brnK4Z-Q" name="Meal_pH_exponent" description="Meal_pH_exponent" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-              <Parameter id="NtQ5D4rrY06P_WOQpC3MMw" name="Meal energy content" description="Energy content of the meal administered" persistable="0" isFixedValue="0" dim="Energy" quantityType="Parameter" visible="1" canBeVaried="1" value="1506240000000" displayUnit="kcal" />
-              <Parameter id="-vRjVK4l_UaxmVqQR4eEsg" name="GET_alpha (Weibull function)" description="Supporting parameter for gastric emptying rate" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="E7UDdg62nESh-_ZRsj7J_Q" visible="0" canBeVaried="1" />
-              <Parameter id="_LSJHSYH-UOklj0c-XcINQ" name="GET_beta (Weibull function)" description="Supporting parameter for gastric emptying rate" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="tmjTClQJy0erOBkWEXuLGA" visible="0" canBeVaried="1" />
-              <Parameter id="EFm-VNcfe0imkR4qF0b2ww" name="Meal volume" description="Approximate volume of the meal administered" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="1" canBeVaried="1" value="0.592" displayUnit="l" />
-              <Parameter id="M-HZTylPx0q4qIc1395xBg" name="Meal fraction solid" description="Fraction of solid components of the meal administered" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" visible="1" canBeVaried="1" value="0.6" />
-              <Parameter id="Ej4vYFgz60iQNNZQ_n3gQA" name="Gallbladder emptying enabled" description="Enable gallbladder emptying. &#xD;&#xA;This will activate discrete mass flow from the gallbladder into the duodenum. &#xD;&#xA;&#xD;&#xA;In order to activate continuous mass flow from the liver into the duodenum &#xD;&#xA;please change the EHC continuous fraction in the Building Block Individual accordingly.&#xD;&#xA;&#xD;&#xA;Please note that enabling gallbladder emptying &#xD;&#xA;does not automatically imply active secretion of the compound into the bile!&#xD;&#xA;&#xD;&#xA;In order to enable active secretion into the bile please &#xD;&#xA;either implement a transport process of the type efflux or P-gp like efflux &#xD;&#xA;at the apical side of the liver &#xD;&#xA;or introduce a biliary clearance process in the Compound Building Block." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="1" />
-              <Parameter id="19T0nBGfGE6KEEfW5cGhrw" name="Gallbladder emptying lag time" description="Lag time between administration of the meal and gallbladder emptying" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" visible="1" canBeVaried="1" value="30" displayUnit="min" />
-              <EventGroupBuilder id="IikJjZxX0EiYZgM4f9sBRQ" name="Fressen_1" mode="Logical" containerType="Other">
-                <Children>
-                  <EventBuilder id="VdwMXhuA9UGxsiSTP-YoWw" name="Meal_StartEvent" description="Meal_StartEvent" oneTime="1" dimension="Dimensionless" formula="dEcmCPlxQk6xzCUrsGrkLA">
-                    <Assignments>
-                      <EventAssignmentBuilder id="z3au1tebE0GROKKWhmTxeA" name="Assignment_1" useAsValue="1" dimension="Volume" formula="on_ehXPjtUu3B67V6iN_jw">
-                        <ObjectPath path="3" />
-                      </EventAssignmentBuilder>
-                      <EventAssignmentBuilder id="FVfhE8s8xkmMYjS9MYGckA" name="Assignment_2" useAsValue="0" dimension="Inversed time" formula="jcfVObYxRkqnq8eeCu3cEQ">
-                        <ObjectPath path="19" />
-                      </EventAssignmentBuilder>
-                      <EventAssignmentBuilder id="XeNw0s1BJkqh7lR5c5oi3w" name="Assignment_3" useAsValue="0" dimension="Dimensionless" formula="KyGW15Nj5UGJlgSzH0AObw">
-                        <ObjectPath path="20" />
-                      </EventAssignmentBuilder>
-                    </Assignments>
-                  </EventBuilder>
-                  <EventBuilder id="RN1Ns82SzEeIsaFZRJ3NlA" name="Meal_StopEvent" description="Meal_StopEvent" oneTime="1" dimension="Dimensionless" formula="QF4KXv07mkSTYhezZW0Ydg">
-                    <Assignments>
-                      <EventAssignmentBuilder id="je8RHMwk_0i4j9qMCSNotQ" name="Assignment_1" useAsValue="0" dimension="Inversed time" formula="R6vanvXe80uB9anndOCk1Q">
-                        <ObjectPath path="19" />
-                      </EventAssignmentBuilder>
-                    </Assignments>
-                  </EventBuilder>
-                  <EventBuilder id="-frqkMi3SUyrvmXTw5PWWg" name="EHC_Start_Event" description="Start of (exponential) Emptying Gallbladder -&gt; Lumen/Duodenum" oneTime="1" dimension="Dimensionless" formula="3G0ylJtpj0SoHv2RiJpHCQ">
-                    <Assignments>
-                      <EventAssignmentBuilder id="eJYs6VUK0EeI_-VvIZq9Gg" name="Assignment_1" useAsValue="1" dimension="Dimensionless" formula="Db21IERYhkWSQgCoxzUBbw">
-                        <ObjectPath path="2" />
-                      </EventAssignmentBuilder>
-                      <EventAssignmentBuilder id="y_tkpPwCGky8GhJL-7RI4A" name="Assignment_2" useAsValue="0" dimension="Amount per time" formula="t8jFIpJaFky00sWLpe-2sw">
-                        <ObjectPath path="21" />
-                      </EventAssignmentBuilder>
-                    </Assignments>
-                  </EventBuilder>
-                  <EventBuilder id="W9rNTno8wkieJ4u1loCEAQ" name="EHC_Stop_Event" description="Stop of (exponential) Emptying Gallbladder -&gt; Lumen/Duodenum" oneTime="1" dimension="Dimensionless" formula="cQUqKgTI1kyjKql-yJRtng">
-                    <Assignments>
-                      <EventAssignmentBuilder id="BRgJRIJHcU20zRrXmtL4uw" name="Assignment_1" useAsValue="1" dimension="Time" formula="HxEjDxGCPUKdRhZI8bFy2w">
-                        <ObjectPath path="21" />
-                      </EventAssignmentBuilder>
-                    </Assignments>
-                  </EventBuilder>
-                  <Parameter id="3pBtGfGe-U2A6UfbkH1Zjw" name="Start time" description="Start time of application" persistable="0" isFixedValue="1" dim="Time" quantityType="Parameter" formula="l3ZbY2rVpUeE5e-XFw6K9Q" visible="1" canBeVaried="1" value="120" displayUnit="h" />
-                </Children>
-                <SourceCriteria>
-                  <DescriptorConditions>
-                    <MatchTagCondition tag="Events" />
-                  </DescriptorConditions>
-                </SourceCriteria>
-              </EventGroupBuilder>
-            </Children>
-            <SourceCriteria>
-              <DescriptorConditions>
-                <MatchTagCondition tag="Events" />
-              </DescriptorConditions>
-            </SourceCriteria>
-          </EventGroupBuilder>
-          <EventGroupBuilder id="VlWolxnbBEiCuywK4pDriA" name="EHC" mode="Logical" containerType="Other">
-            <Children>
-              <Parameter id="JCJvECVzzk675j3TjKzQHQ" name="Gallbladder emptying enabled" description="Enable gallbladder emptying. &#xD;&#xA;This will activate discrete mass flow from the gallbladder into the duodenum. &#xD;&#xA;&#xD;&#xA;In order to activate continuous mass flow from the liver into the duodenum &#xD;&#xA;please change the EHC continuous fraction in the Building Block Individual accordingly.&#xD;&#xA;&#xD;&#xA;Please note that enabling gallbladder emptying &#xD;&#xA;does not automatically imply active secretion of the compound into the bile!&#xD;&#xA;&#xD;&#xA;In order to enable active secretion into the bile please &#xD;&#xA;either implement a transport process of the type efflux or P-gp like efflux &#xD;&#xA;at the apical side of the liver &#xD;&#xA;or introduce a biliary clearance process in the Compound Building Block." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="1" />
-              <EventGroupBuilder id="lO26q6iVUEa82wYReMQ8Hw" name="EHC_1" mode="Logical" containerType="Other">
-                <Children>
-                  <EventBuilder id="7W3jeVjPaU-3J6UTnUR8yQ" name="EHC_Start_Event" description="Start of (exponential) Emptying Gallbladder -&gt; Lumen/Duodenum" oneTime="1" dimension="Dimensionless" formula="lfK8J9OSPUir7oSF8pu1Sg">
-                    <Assignments>
-                      <EventAssignmentBuilder id="NB_DbOwtTEmRzefmV50AEA" name="Assignment_1" useAsValue="1" dimension="Dimensionless" formula="vVEwMPB6uk2zcj9ZjqDYSA">
-                        <ObjectPath path="2" />
-                      </EventAssignmentBuilder>
-                      <EventAssignmentBuilder id="R0UMPsYVGkGLHpuoHcWXNw" name="Assignment_2" useAsValue="0" dimension="Amount per time" formula="t8jFIpJaFky00sWLpe-2sw">
-                        <ObjectPath path="21" />
-                      </EventAssignmentBuilder>
-                    </Assignments>
-                  </EventBuilder>
-                  <EventBuilder id="qKIf4dFvHk-jj0ppVhaueg" name="EHC_Stop_Event" description="Stop of (exponential) Emptying Gallbladder -&gt; Lumen/Duodenum" oneTime="1" dimension="Dimensionless" formula="K7pmvbAKG0mG2iYFT1cSww">
-                    <Assignments>
-                      <EventAssignmentBuilder id="q4aWMuTp1UWgoPKzW1NoIA" name="Assignment_1" useAsValue="1" dimension="Time" formula="5wO_QllX1UOS3hVVKLo2NQ">
-                        <ObjectPath path="21" />
-                      </EventAssignmentBuilder>
-                    </Assignments>
-                  </EventBuilder>
-                  <Parameter id="YhlraQrKcEG1uN6NluhkcA" name="Start time" description="Start time of application" persistable="0" isFixedValue="1" dim="Time" quantityType="Parameter" formula="Qnmar6BNfU2-r295pIVmDA" visible="1" canBeVaried="1" value="240" displayUnit="h" />
-                </Children>
-                <SourceCriteria>
-                  <DescriptorConditions>
-                    <MatchTagCondition tag="Events" />
-                  </DescriptorConditions>
-                </SourceCriteria>
-              </EventGroupBuilder>
-            </Children>
-            <SourceCriteria>
-              <DescriptorConditions>
-                <MatchTagCondition tag="Events" />
-              </DescriptorConditions>
-            </SourceCriteria>
-          </EventGroupBuilder>
-        </Builders>
-        <FormulaCache>
-          <Formulas>
-            <Formula id="aZozMwF_Rkmet40DUcX4DQ" name="DrugMass of particle bin" dim="Amount" formula="ParticleBinDrugMass">
-              <Paths>
-                <Path path="22" as="23" dim="24" />
-              </Paths>
-            </Formula>
-            <Formula id="FSz8UlUWT0OYY1cQSyBiJg" name="InsolubleDrugStartFormula" dim="Amount" formula="0" />
-            <SumFormula id="uZqeiRhVakCqrb7NOKYxEw" name="TotalDrugMass" dim="Amount" variable="M" formulaString="M_#i">
-              <Criteria>
-                <DescriptorConditions>
-                  <MatchTagCondition tag="DrugMass" />
-                </DescriptorConditions>
-              </Criteria>
-            </SumFormula>
-            <Formula id="ApplicationParameter.PARAM_ParticlesReleaseRate" name="PARAM_ParticlesReleaseRate" dim="Amount per time" formula="X&gt;0 ? 3*D*X0^(1/3)/(rho/MW)/(h)/(r0)*X^(2/3)*(PrecipitatedDrugSoluble ? S/MW - DrugLiquid/Liquid : max(S/MW - DrugLiquid/Liquid; 0)) : 0">
-              <Paths>
-                <Path path="25" as="26" dim="24" />
-                <Path path="27" as="28" dim="29" />
-                <Path path="30" as="31" dim="29" />
-                <Path path="32" as="33" dim="34" />
-                <Path path="35" as="36" dim="37" />
-                <Path path="38" as="39" dim="24" />
-                <Path path="40" as="41" dim="42" />
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-                <Path path="53" as="54" dim="55" />
-                <Path path="56" as="57" />
-                <Path path="58" as="59" dim="60" />
-              </Paths>
-            </Formula>
-            <Formula id="KP_cf6Shi0-90K0il8fqaA" name="PassiveDiffusionPl2RBC" dim="Amount per time" formula="SA_bc * fu * (P_pls_rbc * C_pls - P_rbc_pls * C_bc  /K_rbc)">
-              <Paths>
-                <Path path="39" as="24" dim="20" />
-                <Path path="18" as="19" dim="20" />
-                <Path path="50" as="51" dim="52" />
-                <Path path="61" as="62" dim="55" />
-                <Path path="63" as="64" dim="55" />
-                <Path path="65" as="66" />
-                <Path path="67" as="68" dim="60" />
-              </Paths>
-            </Formula>
-            <Formula id="b8gO7rmzo0el0ZRTzcP8Ug" name="PassiveDiffusionPlsToSaliva" dim="Amount per time" formula="fu * (C_pls_art - C_slv / K_slv_pls) * Q_slv">
-              <Paths>
-                <Path path="69" as="70" dim="17" />
-                <Path path="71" as="72" dim="20" />
-                <Path path="39" as="73" dim="20" />
-                <Path path="50" as="51" dim="52" />
-                <Path path="74" as="75" />
-              </Paths>
-            </Formula>
-            <Formula id="oI9O5u8vekG4w47xoMfomA" name="GallbladderEmptyingRate" dim="Amount per time" formula="GallbladderEmptyingRate">
-              <Paths>
-                <Path path="76" as="77" dim="2" />
-              </Paths>
-            </Formula>
-          </Formulas>
-          <StringMap>
-            <Map s="NEIGHBORHOOD|MOLECULE|Drug absorption rate (lumen to mucosa)" id="0" />
-            <Map s="DrugAbsorptionLumenToMucosaRate" id="1" />
-            <Map s="Amount per time" id="2" />
-            <Map s="SOURCE|..|OralApplicationsEnabled" id="3" />
-            <Map s="OralApplicationsEnabled" id="4" />
-            <Map s="SOURCE|MOLECULE" id="5" />
-            <Map s="Drug" id="6" />
-            <Map s="Amount" id="7" />
-            <Map s="MOLECULE|Is floating in lumen" id="8" />
-            <Map s="IsFloatingInLumen" id="9" />
-            <Map s="SOURCE|Intestinal transit rate (absolute)" id="10" />
-            <Map s="w" id="11" />
-            <Map s="Inversed time" id="12" />
-            <Map s="TARGET|FillLevelFlag" id="13" />
-            <Map s="FillLevelFlagNext" id="14" />
-            <Map s="TARGET|..|Blood flow rate" id="15" />
-            <Map s="Q" id="16" />
-            <Map s="Flow" id="17" />
-            <Map s="SOURCE|MOLECULE|Concentration" id="18" />
-            <Map s="C_pls" id="19" />
-            <Map s="Concentration (molar)" id="20" />
-            <Map s="Organism|Hematocrit" id="21" />
-            <Map s="HCT" id="22" />
-            <Map s="SOURCE|..|Blood flow rate" id="23" />
-            <Map s="C_bc" id="24" />
-            <Map s="SOURCE|..|Mucosa blood flow fraction" id="25" />
-            <Map s="fractQ" id="26" />
-            <Map s="C" id="27" />
-            <Map s="NEIGHBORHOOD|MOLECULE|Mass transfer rate (intestine to mucosa blood cells)" id="28" />
-            <Map s="MassTransferIntestineToMucosaBCRate" id="29" />
-            <Map s="NEIGHBORHOOD|MOLECULE|Mass transfer rate (intestine to mucosa plasma)" id="30" />
-            <Map s="MassTransferIntestineToMucosaPlasmaRate" id="31" />
-            <Map s="NEIGHBORHOOD|MOLECULE|Mass transfer rate (mucosa to portal vein blood cells)" id="32" />
-            <Map s="MassTransferMucosaToPveBCRate" id="33" />
-            <Map s="NEIGHBORHOOD|MOLECULE|Mass transfer rate (mucosa to portal vein plasma)" id="34" />
-            <Map s="MassTransferMucosaToPvePlasmaRate" id="35" />
-            <Map s="Q_liv" id="36" />
-            <Map s="SOURCE|..|..|PortalVein|Blood flow rate" id="37" />
-            <Map s="Q_pve" id="38" />
-            <Map s="TARGET|MOLECULE|Concentration" id="39" />
-            <Map s="C_cell" id="40" />
-            <Map s="C_int" id="41" />
-            <Map s="NEIGHBORHOOD|MOLECULE|P*SA interstitial -&gt; intracellular" id="42" />
-            <Map s="PA_int_cell" id="43" />
-            <Map s="NEIGHBORHOOD|MOLECULE|P*SA intracellular -&gt; interstitial" id="44" />
-            <Map s="PA_cell_int" id="45" />
-            <Map s="NEIGHBORHOOD|MOLECULE|Partition coefficient (interstitial/water)" id="46" />
-            <Map s="K_water_int" id="47" />
-            <Map s="NEIGHBORHOOD|MOLECULE|Partition coefficient (intracellular/water)" id="48" />
-            <Map s="K_water_cell" id="49" />
-            <Map s="MOLECULE|Fraction unbound (plasma)" id="50" />
-            <Map s="fu" id="51" />
-            <Map s="Fraction" id="52" />
-            <Map s="NEIGHBORHOOD|MOLECULE|P (plasma&lt;-&gt;interstitial)" id="53" />
-            <Map s="P_endothelial" id="54" />
-            <Map s="Velocity" id="55" />
-            <Map s="NEIGHBORHOOD|MOLECULE|Partition coefficient (interstitial/plasma)" id="56" />
-            <Map s="K_int_pls" id="57" />
-            <Map s="NEIGHBORHOOD|Surface area (plasma/interstitial)" id="58" />
-            <Map s="SA" id="59" />
-            <Map s="Area" id="60" />
-            <Map s="MOLECULE|P (blood cells-&gt;plasma)" id="61" />
-            <Map s="P_rbc_pls" id="62" />
-            <Map s="MOLECULE|P (plasma-&gt;blood cells)" id="63" />
-            <Map s="P_pls_rbc" id="64" />
-            <Map s="MOLECULE|Partition coefficient (blood cells/plasma)" id="65" />
-            <Map s="K_rbc" id="66" />
-            <Map s="NEIGHBORHOOD|Surface area (blood cells/plasma)" id="67" />
-            <Map s="SA_bc" id="68" />
-            <Map s="SOURCE|..|Saliva flow rate" id="69" />
-            <Map s="Q_slv" id="70" />
-            <Map s="SOURCE|..|..|ArterialBlood|Plasma|MOLECULE|Concentration" id="71" />
-            <Map s="C_pls_art" id="72" />
-            <Map s="C_slv" id="73" />
-            <Map s="NEIGHBORHOOD|MOLECULE|Partition coefficient (intracellular/plasma)" id="74" />
-            <Map s="K_slv_pls" id="75" />
-            <Map s="Organism|Gallbladder|Gallbladder emptying rate" id="76" />
-            <Map s="GallbladderEmptyingRate" id="77" />
-          </StringMap>
-        </FormulaCache>
-      </PassiveTransports>
-      <Reactions id="esHKiSmAj0Cg7Dw7gEeA2Q" name="S1" bbVersion="0">
-        <FormulaCache>
-          <StringMap />
-        </FormulaCache>
-      </Reactions>
-      <SpatialStructure id="wBIJq8d_VUWC72nO3opZig" name="S1" bbVersion="0">
-        <GlobalMoleculeDependentProperties id="aCDZeL-HmU-PIo39dN7UMg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-          <Children>
-            <Parameter id="W5A89U7fAkeECwqJHUIxNA" name="P_bc_pls_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" buildMode="Global" visible="0" canBeVaried="1" />
-            <Parameter id="iWQ2vB4HL0WSj6O6ivMe0g" name="Intestinal permeability (paracellular)" description="Intestinal permeability via paracellular route" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" buildMode="Global" visible="1" canBeVaried="1" value="0" displayUnit="cm/min" />
-            <Parameter id="4Ne4PFjY90mSt3h5E9k8sg" name="Intestinal permeability (transcellular)" description="Intestinal permeability via transcellular route" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="IntestinalPermeability_PKSim.PARAM_P_int" buildMode="Global" visible="1" canBeVaried="1" displayUnit="cm/min" />
-            <Parameter id="jT_zQpK37EKus2E7fYAusw" name="Mucosa permeability scale factor (transcellular)" description="Used for scaling mucosa permeability with intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_MucosaPermeabilityScaleFactor_trans" buildMode="Global" visible="0" canBeVaried="0" />
-            <Parameter id="4rlNT-8LXU6c4_n8NPVDjw" name="P (plasma-&gt;blood cells)" description="Permeability from plasma to blood cells" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_P_pls_rbc" buildMode="Global" visible="1" canBeVaried="1" displayUnit="cm/min" />
-            <Parameter id="EskQOs4Mhk2oBlyru23GlQ" name="Default Intestinal permeability (transcellular)" description="Default Intestinal permeability via transcellular route" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="IntestinalPermeability_PKSim.PARAM_P_int_default" buildMode="Global" visible="0" canBeVaried="0" displayUnit="cm/min" />
-            <Parameter id="QgC0ENq2TkSPtoLf38lHsw" name="P_pls_bc_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" buildMode="Global" visible="0" canBeVaried="1" />
-            <Parameter id="7bPGA0780kWMpluZUaWTPg" name="Partition coefficient (blood cells/plasma)" description="Partition coefficient between blood cells and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" buildMode="Global" visible="1" canBeVaried="1" />
-            <Parameter id="PZjhJvpecUi3Amw9U0f0Uw" name="P (blood cells-&gt;plasma)" description="Permeability from blood cells to plasma" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_P_rbc_pls" buildMode="Global" visible="1" canBeVaried="1" displayUnit="cm/min" />
-            <Parameter id="_h1I3WvyJUGHtsEf7FfL6w" name="Fraction unbound (plasma)" description="Fraction unbound in plasma" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" formula="DistributionInVitro_PKSim.PARAM_fu" buildMode="Global" visible="1" canBeVaried="0" />
-            <Parameter id="Ywk4dNfVEUu8m7mo_malFQ" name="Blood/Plasma concentration ratio" description="Blood to plasma concentration ratio" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionInVitro_PKSim.PARAM_Blood2Plasma" buildMode="Property" visible="1" canBeVaried="1" />
-          </Children>
-        </GlobalMoleculeDependentProperties>
-        <TopContainers>
-          <Container id="_7RSv_STIUOcPonMKsM5yA" name="Organism" description="Organism" icon="Organism" mode="Logical" containerType="Organism">
-            <Children>
-              <Parameter id="kPqWxXZqf0KiLn6vGCXBxg" name="Specific clearance (endosome)" description="Specific endosomal clearance" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="Individual_PKSim.PARAM_CLSpec_endosomal_global" visible="1" canBeVaried="1" displayUnit="1/min" />
-              <Parameter id="YCkLx9EbAUGWge1sS7mBzQ" name="SA proportionality factor" description="Proportionality factor for the surface area plasma &lt;=&gt; int" persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" visible="0" canBeVaried="1" value="9500" displayUnit="1/cm" />
-              <Parameter id="qh_uWMytPEuRsSQBkvwO-Q" name="Volume (plasma)" description="Whole body plasma volume" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="Individual_PKSim.PARAM_VolumePlasma" visible="0" canBeVaried="0" displayUnit="l" />
-              <Parameter id="2jPy42SbDk23b_v6TOQXEA" name="Surface area scaling exponent" description="Global shape parameter; used (as exponent) for calculating diffusion stream between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-              <Parameter id="SHnmPWHyE0OFvACxy1H0Nw" name="Weight" description="Body weight" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="Individual_PKSim.PARAM_BW" visible="1" canBeVaried="1" displayUnit="kg" />
-              <Parameter id="CqAdr8WBk0Siq2GCDFQrvQ" name="Estimated gestational age" description="Estimated gestational age" persistable="0" isFixedValue="0" dim="Age in weeks" quantityType="Parameter" formula="GFR_Calculation.PARAM_PostMenstrualAge" visible="0" canBeVaried="1" displayUnit="week(s)" />
-              <Parameter id="k3y5bKD2ckShJ-5GsvxKOw" name="BMI" description="Body mass index" persistable="0" isFixedValue="0" dim="BMI" quantityType="Parameter" formula="BMI.PARAM_BMI" visible="1" canBeVaried="1" displayUnit="kg/m²" />
-              <Parameter id="Ae181Ld6c0Kksk3eawJkZw" name="Vf (neutral lipid, blood cells)-WS" description="Fractional volume content of neutral lipid in blood cells used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.003" />
-              <Parameter id="FsqcpzUYf0ezmagAaPFTsw" name="Vf (water,plasma)" description="Fractional volume content of water in plasma used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.926" />
-              <Parameter id="CbBSbGljZkGgTxiaOv4bEQ" name="Vf (water,interstitial)" description="Fractional volume content of water in interstitial space used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.935" />
-              <Parameter id="4IkIg96iYEiUnWsM7s2-RA" name="Vf (water,blood cells)" description="Fractional volume content of water in blood cells used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.625" />
-              <Parameter id="2uGzg-GenkmdSUS_Vb3ngQ" name="Vf (protein,plasma)" description="Fractional volume content of protein in plasma used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.067" />
-              <Parameter id="EaXehL1ul0ORkonn7tJ41g" name="Vf (protein,blood cells)" description="Fractional volume content of protein in blood cells used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.325" />
-              <Parameter id="mS6cURMNTUqykPJZ5ymdFQ" name="Protein ratio (interstial/plasma)" description="The ratio between the protein volume fraction in interstitial space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.37" />
-              <Parameter id="CD3EZjB050uzmzcTKrTQog" name="Vf (lipid, blood cells)" description="Fractional volume content of lipid in blood cells" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.005" />
-              <Parameter id="sTCeaQ0JOEO_nkJCnSwhuQ" name="Vf (lipid, plasma)" description="Fractional volume content of lipid in plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.007" />
-              <Parameter id="UXfk1_H7H06oWUUt1WgO1A" name="Vf (neutral lipid, plasma)-RR" description="Fractional volume content of neutral lipid in plasma used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0032" />
-              <Parameter id="QKxtZjvf506qD30Qrm8zQg" name="Thickness (endothelium)" description="Thickness of vascular endothelium" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="3E-06" displayUnit="cm" />
-              <Parameter id="V6iHmLMQg0Kmua5E5P-Bqw" name="pH (plasma)" description="pH of plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.4" />
-              <Parameter id="TCJyJmYcIU2H1yqKBNOdXQ" name="pH (blood cells)" description="Intracellular pH of blood cells" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.22" />
-              <Parameter id="x14okXjSBUOsO14DHmXMtQ" name="pH (interstitial)" description="pH of interstitial space" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.4" />
-              <Parameter id="SIU4L3vxK0e_qBzip0MsZQ" name="pH (intracellular)" description="pH of intracellular space" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7" />
-              <Parameter id="DgVhqpti9kulqKriQAP18A" name="R*T" description="Gas constant-body temperature product (37°C)" persistable="0" isFixedValue="0" dim="RT" quantityType="Parameter" visible="1" canBeVaried="0" value="928.8" displayUnit="N*cm/mol" />
-              <Parameter id="z1zl-fWlBk-pTBGswUDPAw" name="Na" description="Avogadro constant" persistable="0" isFixedValue="0" dim="Inversed mol" quantityType="Parameter" visible="0" canBeVaried="0" value="6.022E+17" displayUnit="1/mol" />
-              <Parameter id="lyZ2vzfG2Ue9AVRmp6XyLQ" name="Gestational age" description="Gestational age" persistable="0" isFixedValue="0" dim="Age in weeks" quantityType="Parameter" visible="1" canBeVaried="1" value="40" displayUnit="week(s)" />
-              <Parameter id="IHA8ehcfRk6x-_UO_gqOHQ" name="Age" description="Age" persistable="0" isFixedValue="0" dim="Age in years" quantityType="Parameter" visible="1" canBeVaried="1" value="30" displayUnit="year(s)" />
-              <Parameter id="a6g1Z2bfR0uECAzTb7yCVg" name="Fraction endosomal (global)" description="Fraction of endosomal space in vascular endothelium" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" visible="1" canBeVaried="1" value="0.2" />
-              <Parameter id="ne8Uhyg3cEin2FKViZ4odw" name="Vf (neutral lipid, plasma)-PT" description="Fractional volume content of neutral lipid in plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0035" />
-              <Parameter id="p1LqFXbVd0ebcKnR_7ca8Q" name="Vf (neutral phospholipid, blood cells)-WS" description="Fractional volume content of neutral phospholipid in blood cells used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0059" />
-              <Parameter id="5kkwsCA1e0iu5ouikNb5tA" name="Vf (neutral phospholipid, plasma)-RR" description="Fractional volume content of neutral phospholipid in plasma used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0021" />
-              <Parameter id="pOa9FRem9EWbAx-wJQvG7g" name="Surface/Volume ratio (blood cells)" description="Surface area to volume ratio of blood cells" persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" visible="0" canBeVaried="1" value="167000" displayUnit="1/cm" />
-              <Parameter id="0CowVQ8W706V2YoV38lrcQ" name="Vf (phospholipid, plasma)-PT" description="Fractional volume content of phospholipid in plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.00225" />
-              <Parameter id="o9Ag97rZCU6mDOEBuUzUgw" name="Vf (acidic phospholipids, blood cells)-WS" description="Fractional volume content of acidic phospholipid in blood cells used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.001" />
-              <Parameter id="vq2R3QjlUEiiVwV45BEJJQ" name="Vf (neutral lipid, blood cells)-RR" description="Fractional volume content of neutral lipid in blood cells used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0012" />
-              <Parameter id="k6TSjDbjeEGaiJORU-1pyw" name="Plasma protein scale factor" description="Scale factor for the fraction unbound in plasma. This factor can be used if changes in the plasma protein concentration and, as a result, in the plasma protein binding of the drug are expected due to e.g. ageing or certain diseases such as cirrhosis, sepsis, or renal failure" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="1" />
-              <Parameter id="hMK0NlPolkCefjsy_acsJQ" name="Fraction of endosomal uptake from plasma (global)" description="Fraction of drug uptake from plasma into endosomal space relative to total uptake from plasma and interstitial space" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-              <Parameter id="SGjiwkwIPk2MuP4RDUV5kA" name="Ontogeny factor (alpha1-acid glycoprotein)" description="Ontogeny factor (α1-acid glycoprotein)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-              <Parameter id="Gj2ZLAZookaSO1CK_l4QNg" name="Ontogeny factor (albumin)" description="Ontogeny factor (albumin)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-              <Parameter id="Xod_droqekqQcHs8397N2w" name="Height" description="Body height" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="16.996" displayUnit="cm" />
-              <Parameter id="SnaCUnG_bE23QwQvyBpttA" name="Vf (neutral phospholipid, blood cells)-RR" description="Fractional volume content of neutral phospholipid in blood cells used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0033" />
-              <Parameter id="Xg6W9oFyME2O5ArOgtCjVw" name="Vf (water,plasma)-PT" description="Fractional volume content of water in plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.945" />
-              <Parameter id="8yLzalc1JEi0Xak7CDxlbg" name="Acidic phospholipids (blood cells) [mg/g] - RR" description="Concentration of acidic phospholipids in red blood cells [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.57" />
-              <Parameter id="SfeS7Vkh-kq38B2zw0QgOw" name="Fraction recycled to plasma (global)" description="Fraction of drug recycling to plasma relative to total recycling to plasma and interstitial space" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-              <Parameter id="qATL0VQ9ZUad8zDgULojYA" name="Vf (intracellular water, blood cells)-RR" description="Fractional volume content of intracellular water in blood cells used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.63" />
-              <Parameter id="mlqY1SYhSkeR-a3lUkh8cg" name="Rate constant for endosomal uptake (global)" description="Rate constant for endosomal uptake for all organs" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" visible="1" canBeVaried="1" value="0.36" displayUnit="1/min" />
-              <Parameter id="IBDIrp7L406mxIhnEzm1hg" name="Rate constant for recycling from endosomal space (global)" description="Rate constant for recycling from endosomal space for all organs" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" visible="1" canBeVaried="1" value="0.083" displayUnit="1/min" />
-              <DistributedParameter id="2HRZYeG3kky1QL70qLOWWw" name="Hematocrit" description="Hematocrit" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="bhamT5cUME63nIB4NyPxUw" mode="Logical" visible="1">
-                <Children>
-                  <Parameter id="gM89EtRIT0GrB3NujezUEA" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                  <Parameter id="5aMJqeLatEeo901406jBJA" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.47" />
-                </Children>
-              </DistributedParameter>
-              <DistributedParameter id="anL-aVeRTkyDivEbJ0TlGQ" name="MeanBW" description="Weight" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="enditrKem0aMNbNd74qI7g" mode="Logical" visible="0" displayUnit="kg">
-                <Children>
-                  <Parameter id="C5WpH25VpEeE5b2r3x1-gg" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" displayUnit="kg" />
-                  <Parameter id="aomFscoBLEORQa77Kp1jWw" name="Mean" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" visible="0" canBeVaried="1" value="60.034" displayUnit="kg" />
-                  <Parameter id="1VrLW6KOxEeCKaYdDfwKEQ" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" visible="0" canBeVaried="1" value="3.0017" displayUnit="kg" />
-                </Children>
-              </DistributedParameter>
-              <DistributedParameter id="aVu6Z6wQEkyM184xiuEi2Q" name="MeanHeight" description="Height" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="DYM7WGn-7kyvZN8Oq30NLQ" mode="Logical" visible="0" displayUnit="cm">
-                <Children>
-                  <Parameter id="jKFjG9SPMEqkQRhAtWnwOw" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" displayUnit="cm" />
-                  <Parameter id="s_16Tx64ZkO-h7xVcXc_3Q" name="Mean" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="16.996" displayUnit="cm" />
-                  <Parameter id="t_SLJw4DK0Od6zhMRhPvwA" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.59486" displayUnit="cm" />
-                </Children>
-              </DistributedParameter>
-              <Container id="fTFGCLAcaU24atGRIlfo3Q" name="PeripheralVenousBlood" description="Peripheral Venous Blood" icon="VenousBlood" mode="Logical" containerType="Organ" />
-              <Container id="F39z2HCDsEulTYZYELHdog" name="VenousBlood" description="VenousBlood" icon="VenousBlood" mode="Logical" containerType="Organ">
-                <Tags>
-                  <Tag value="BloodOrgan" />
-                </Tags>
-                <Children>
-                  <Parameter id="73BbH8AAGEOYIoMY0--rcw" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="Individual_PKSim.PARAM_Tissue_Weight" visible="0" canBeVaried="1" displayUnit="kg" />
-                  <Parameter id="v7qvrtwFVUO1nwLuUEd50A" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                  <Parameter id="tc-i6fkZukqgORczlM1ijw" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="0" value="0.75" />
-                  <Parameter id="RiP72T6Y4EysbUWSf40cdw" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="1" />
-                  <DistributedParameter id="8CNqo0vlKUSEJ4bgtzxKgQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="qrigwKerfkanKkcesf7iiQ" mode="Logical" visible="1" displayUnit="l">
-                    <Children>
-                      <Parameter id="YnYKVVn4u0e-83so_yDOFA" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.501140854040494" displayUnit="l" />
-                      <Parameter id="LAqaqsREOU-4WwPOU3pcuQ" name="Mean" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" value="0.776531873" displayUnit="l" />
-                      <Parameter id="5LeIYvxfmEmA_FZ55t31Zw" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" value="0.038826594" displayUnit="l" />
-                    </Children>
-                  </DistributedParameter>
-                  <Container id="AsKjCr0qtU6a-XJrIrGPTA" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="BloodOrgan" />
-                      <Tag value="VenousBlood" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="WF6D6TKPxEOsARPPVus_Wg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="zeZ-3Cn9HUmyZc-zaXBFfQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_pls_BloodOrgan_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Container id="4TdstCp8dUWjwDmCTlpW4g" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                        <Children>
-                          <Parameter id="WT7Dct9XbUS1bhPpqsWsww" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" visible="0" canBeVaried="0" />
-                          <Parameter id="x0brc9VbEkaFp-8u-BNerw" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                        </Children>
-                      </Container>
-                    </Children>
-                  </Container>
-                  <Container id="tLK5A0Qv_EaJTZDJ7FqJQA" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="BloodOrgan" />
-                      <Tag value="VenousBlood" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="PeBySdE5Q0KqMS22Cccrdw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="w3MCaB3OEkmayKsA6evd4A" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_bc_blood_organ_4comp" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Container id="iFBmy8AZ-kqE_6drsy7dgg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                        <Children>
-                          <Parameter id="QEV4afEIiUyovfGkA6BvXg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" visible="0" canBeVaried="0" />
-                          <Parameter id="xMZCWbiQYEmzChx8-G633g" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                        </Children>
-                      </Container>
-                    </Children>
-                  </Container>
-                </Children>
-              </Container>
-              <Container id="J4fZwXKgB0aTLtAzGj0RZw" name="ArterialBlood" description="ArterialBlood" icon="ArterialBlood" mode="Logical" containerType="Organ">
-                <Tags>
-                  <Tag value="BloodOrgan" />
-                </Tags>
-                <Children>
-                  <Parameter id="wu9PzBhNmkOSWo6HvS9U8w" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="Individual_PKSim.PARAM_Tissue_Weight" visible="0" canBeVaried="1" displayUnit="kg" />
-                  <Parameter id="P_PD3IimwUesolj33v1aLQ" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                  <Parameter id="oeROAGxqR0uINO5YLBdU1Q" name="Peripheral blood flow fraction" description="Blood flow fraction in organ used for calculation of peripheral venous blood concentrations" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" visible="1" canBeVaried="1" value="0" />
-                  <Parameter id="kRrheAR-vESFGALYluAW4w" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="0" value="0.75" />
-                  <Parameter id="GhkH1_3g5kq9aVclw1a9YQ" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="1" />
-                  <DistributedParameter id="5YUx9dPBrkyYHP-qJmRWrg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="yLnuftcCTE2lwlnsVaJklA" mode="Logical" visible="1" displayUnit="l">
-                    <Children>
-                      <Parameter id="nq40PxbrzU2k1DQopXmFIw" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.500575515426459" displayUnit="l" />
-                      <Parameter id="MPBkmMqofkaxCHk9PxX2lg" name="Mean" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" value="0.337622553" displayUnit="l" />
-                      <Parameter id="-oqHOcpm80WezJvlbq8K8g" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" value="0.016881128" displayUnit="l" />
-                    </Children>
-                  </DistributedParameter>
-                  <Container id="B0yJEO0-kUqHLgCh369ADQ" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="ArterialBlood" />
-                      <Tag value="BloodOrgan" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="Muxat8FaRkaVR9biLxjTzw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="2rHDdaM8i0iW0UFKnfxOxg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_pls_BloodOrgan_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Container id="pQQ8UjV7b0ql0pltZr4l-g" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                        <Children>
-                          <Parameter id="UQxH0DcXkU-n0tT4zljdxg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" visible="0" canBeVaried="0" />
-                          <Parameter id="9hWy9xXTY0y6irTQI4JOvA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                        </Children>
-                      </Container>
-                    </Children>
-                  </Container>
-                  <Container id="BuQVS6yXyUaIq4-4XAWfSA" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="ArterialBlood" />
-                      <Tag value="BloodOrgan" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="gXJFpuAfm0yN1B6lJrsqRA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="utQaY84PKkGj_2PJEhBJ3w" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_bc_blood_organ_4comp" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Container id="tFTgHoJI3EuKywntKQRclw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                        <Children>
-                          <Parameter id="QnNO9wKF_Ei_LDRPA_0BVg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" visible="0" canBeVaried="0" />
-                          <Parameter id="vW89Z8gnGEC4M9fL4fvKEA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                        </Children>
-                      </Container>
-                    </Children>
-                  </Container>
-                </Children>
-              </Container>
-              <Container id="EOCNYCiyR0-ddQmB3lY2mg" name="Gallbladder" description="Bile compartment used to collect excretion to the bile" mode="Physical" containerType="Organ">
-                <Tags>
-                  <Tag value="Liver" />
-                </Tags>
-                <Children>
-                  <Parameter id="xEC-oe1hCUq3-G3pe4PZJQ" name="Gallbladder emptying rate" description="Rate of gallbladder emptying" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" visible="0" canBeVaried="0" value="0" displayUnit="µmol/min" />
-                  <Parameter id="D94A2TkTR0agmYu5SaArmg" name="Time to complete gallbladder refilling" description="Time to complete gallbladder refilling" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" formula="Individual_PKSim.PARAM_GallbladderRefillTime" visible="1" canBeVaried="1" displayUnit="min" />
-                  <Parameter id="N1ZVoSGBZUORG3HELRHQAQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="l" />
-                  <Parameter id="SWAUNrchVUS4gdDk_Osy6Q" name="Gallbladder ejection half-time" description="Gallbladder ejection half-time" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" visible="1" canBeVaried="1" value="19.7" displayUnit="min" />
-                  <Parameter id="nAjaD3F6l0mUFE_V2IuSwQ" name="Gallbladder ejection fraction" description="Gallbladder ejection fraction" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" visible="1" canBeVaried="1" value="0.65" />
-                  <Container id="mpCD2xaYUU-WZ9NQCp6VRg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule" />
-                </Children>
-              </Container>
-              <Container id="z7QbBzDQ8Uin2-FpKLR5DA" name="Bone" description="Bone" icon="Bone" mode="Logical" containerType="Organ">
-                <Tags>
-                  <Tag value="TissueOrgan" />
-                </Tags>
-                <Children>
-                  <Parameter id="FAeHmJyAzE-zRaeJ_OHTjg" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="Individual_PKSim.PARAM_Tissue_Weight" visible="0" canBeVaried="1" displayUnit="kg" />
-                  <Parameter id="jIcw9CBzr0i5FEH7Ef99KQ" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Q_from_Qspec" visible="1" canBeVaried="1" displayUnit="l/min" />
-                  <Parameter id="pjBynKWF80-48cGvGxePhg" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate_Bone" visible="1" canBeVaried="1" displayUnit="l/min" />
-                  <Parameter id="Ft0Vnl2YqkGf1x1nVdaY_A" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Lymph_flow_rate_Bone" visible="1" canBeVaried="1" displayUnit="l/min" />
-                  <Parameter id="4_6NnMBkZkKVtXuTK1FUcQ" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="VascularEndoVolume.VOLUME_VascularEndo_bon" visible="1" canBeVaried="0" displayUnit="l" />
-                  <Parameter id="1gldi4QKlEi5fqGrFITwZA" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_f_cell" visible="1" canBeVaried="1" />
-                  <Parameter id="KLh73v2hqkSIIQjdIlOX3A" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                  <Parameter id="URjojN2idkC-HkzJKzwpvw" name="Peripheral blood flow fraction" description="Blood flow fraction in organ used for calculation of peripheral venous blood concentrations" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" visible="1" canBeVaried="1" value="0" />
-                  <Parameter id="GSxSvXu9SUKNukYDib82TQ" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="2" />
-                  <Parameter id="Hu6_cNxVrUKoXqpfdVEuhA" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                  <Parameter id="njaK2nkOIE2bAhMtDgnHww" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.8" />
-                  <Parameter id="2LBPaE5s-0-GhUB11j3xoA" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="3.3E-07" displayUnit="µm" />
-                  <Parameter id="X3T4vyYV1Ee1uCPsnEqsjA" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="9E-08" displayUnit="µm" />
-                  <Parameter id="LST0KilxYU-HfRnIF1mkEw" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" visible="1" canBeVaried="1" value="3.88888888888889E-11" displayUnit="ml/min/N" />
-                  <Parameter id="g9XCAlP9X0OPzeRc3K6VWg" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.074" />
-                  <Parameter id="nRbcWVqWVUedsfOKCQuH0w" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.268" />
-                  <Parameter id="Tkgg3UMDukipsmSy35NsHw" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.034" />
-                  <Parameter id="23M8M57WgkKcfX82Jv--9Q" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.268" />
-                  <Parameter id="YwYZl3EJeECrt9EUxzRNGA" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0011" />
-                  <Parameter id="4mf6jsmcek6e4MWcJ9LdGw" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.1" />
-                  <Parameter id="wVNEl0TK7ES1TafMBH1W3w" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.05" />
-                  <Parameter id="JL_HGCYdqEu3YMAp1mlfdg" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.465" />
-                  <Parameter id="8iWOmnc5W0GcBUYMHh8U_w" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.439" />
-                  <Parameter id="AT_NvqxMWEi8U5FbWAyMng" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-                  <Parameter id="JkW7ZjNIC06VSV49s8bRwQ" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.1" />
-                  <Parameter id="-hRNpSl8DkCm7jdQWlk7VA" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.017" />
-                  <Parameter id="TmeI5p7YYkilllQWkev1pg" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0174" />
-                  <Parameter id="oyHEcV8DLkOfwjoztA7LTA" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0016" />
-                  <Parameter id="rvllfmbvSEC6YC5mtJO6ug" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0022" />
-                  <Parameter id="bTOO2nxOG0qUORvAAiEYSw" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.1" />
-                  <Parameter id="7Mi57nHVjkm-kaiQw-UzQA" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.21" />
-                  <Parameter id="GlazJjO8dESOP628NUZsIA" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.26" />
-                  <Parameter id="Adz57oJ6Yke9pUVH3nlb0w" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.317" />
-                  <Parameter id="z3kyesfewkOw8B7SR5ggmw" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0008" />
-                  <Parameter id="VTsxpEFRkEKfOLhfAVTyfw" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.67" />
-                  <DistributedParameter id="ZHXIerd5i0eoAzTtxPFLFA" name="Specific blood flow rate" description="Blood flow rate normalized to the organ volume" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" formula="-4pssNO3QEOh8l6J5tNBFQ" mode="Logical" visible="1" displayUnit="ml/min/100g organ">
-                    <Children>
-                      <Parameter id="-S1NB7v_jU6qFn0rWD3MyQ" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" displayUnit="ml/min/100g organ" />
-                      <Parameter id="mJ-qr3ojr0i83kwWBDEQDg" name="Mean" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" visible="0" canBeVaried="1" value="0.027495" displayUnit="ml/min/100g organ" />
-                      <Parameter id="TZPPDzZDakWEHA5tSyKO5w" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" visible="0" canBeVaried="1" value="0.00137475" displayUnit="ml/min/100g organ" />
-                    </Children>
-                  </DistributedParameter>
-                  <DistributedParameter id="cNs43HujM0W-dcQTRamN3w" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="WkjshN5q50W0GB-WhfeWfw" mode="Logical" visible="1" displayUnit="l">
-                    <Children>
-                      <Parameter id="AEnksmcHDEGw9kr8EdWS0w" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.50325782866479" displayUnit="l" />
-                      <Parameter id="E9fahDb7PUm7GTpViIL1wQ" name="Mean" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" value="9.5207652443088" displayUnit="l" />
-                      <Parameter id="QPQ7QHqBh0OMW0diW0CriA" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" value="0.105290142836811" displayUnit="l" />
-                    </Children>
-                  </DistributedParameter>
-                  <Container id="5qhBG-74sEmSAgcDLdsKOw" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Bone" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="1v8evC1C70S1i_IssxvFyg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="jLHmUFBY0kOX8VQnUsAdsQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Container id="MfieV5G-okK_MMHvu7tCkQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                        <Children>
-                          <Parameter id="BItvf9_mdUq3ISiln5ePDw" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                          <Parameter id="ymhkG3mbwUmDmz99u4gevQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" visible="0" canBeVaried="0" />
-                        </Children>
-                      </Container>
-                    </Children>
-                  </Container>
-                  <Container id="FJ8onNQ3S0m05n8qe_e3lQ" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Bone" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="WOqYFzTgT064wxkN-IWsGw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="_uQ26MeZAkKQjITKebIu_g" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Container id="B1n2WYi-ZkaOx0w7wlmWAw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                        <Children>
-                          <Parameter id="b6LmLWIV4kePfcI2QiEdHw" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                          <Parameter id="Rjuv4hCMtEiKZmtcUDpzDQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" visible="0" canBeVaried="0" />
-                        </Children>
-                      </Container>
-                    </Children>
-                  </Container>
-                  <Container id="I4hGcwkmzkmEz3yfrqW3BQ" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Bone" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="dBpsGKbU8kanpCv7CXIFDg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="Oz5_YV_Rf0y3W_l5FteqcQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Parameter id="unM7mlhHFUyBKPSy8cG5Cg" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_pH_INT" visible="1" canBeVaried="1" />
-                      <Container id="9nh50ju3xkutGxhJ0FspbQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                        <Children>
-                          <Parameter id="nJMstMtwsEKJFGoLJx1YjA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                          <Parameter id="n0ImzFPySUKRpIXmmP4kFg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_bon" visible="0" canBeVaried="0" />
-                        </Children>
-                      </Container>
-                    </Children>
-                  </Container>
-                  <Container id="XBQCWlrnIU6dG_CYS9pmbQ" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Bone" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="eeSYqSQJJkWZ7YUsYSC5qA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="hV_fwpqwD06bmOAavWP3aQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Parameter id="j_FqK7kwkkWSXJ9Jh8cUmA" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7" />
-                      <Container id="VALO5s62DkSWx9H6V2qUqg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                        <Children>
-                          <Parameter id="fp6OJDn9Tkuo-9Prrur7Iw" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                          <Parameter id="KU97o2iklUuh-7XOz3wmKA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_bon" visible="0" canBeVaried="0" />
-                        </Children>
-                      </Container>
-                    </Children>
-                  </Container>
-                </Children>
-              </Container>
-              <Container id="Hu4Nl2C_d0OozLJSUsk5Ug" name="Brain" description="Brain" icon="Brain" mode="Logical" containerType="Organ">
-                <Tags>
-                  <Tag value="TissueOrgan" />
-                </Tags>
-                <Children>
-                  <Parameter id="P4YQN15cfUyZIyEkNbzyDg" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="Individual_PKSim.PARAM_Tissue_Weight" visible="0" canBeVaried="1" displayUnit="kg" />
-                  <Parameter id="a8ZLx4Tx9U-sVYrN0k-MKQ" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="VascularEndoVolume.VOLUME_VascularEndo_brn" visible="1" canBeVaried="0" displayUnit="l" />
-                  <Parameter id="KwYFh18AiUidLnLmdMen2Q" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Lymph_flow_rate_Brain" visible="1" canBeVaried="1" displayUnit="l/min" />
-                  <Parameter id="l9bM30P1h0m6z6pIYStWhA" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate_Brain" visible="1" canBeVaried="1" displayUnit="l/min" />
-                  <Parameter id="5SFQMTmcdEaquhhvAWEXug" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_f_cell" visible="1" canBeVaried="1" />
-                  <Parameter id="1Zx3IBbSlEyaGX_0TLCZxA" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Q_from_Qspec" visible="1" canBeVaried="1" displayUnit="l/min" />
-                  <Parameter id="45XYtXcKXk-3EmPW527iCw" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                  <Parameter id="12WJ_NWsIU262ZSOiJugNw" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0" />
-                  <Parameter id="s7m_VOJqAUuxWL-3imGC9g" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                  <Parameter id="HESqM7zGr0yO85NJCvfFTA" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.05" />
-                  <Parameter id="OssyXdSUdUi5-zz29GR-ew" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" visible="1" canBeVaried="1" value="5E-14" displayUnit="ml/min/N" />
-                  <Parameter id="o37r8TDox0mLpSqBiHyDvQ" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="2.5E-07" displayUnit="µm" />
-                  <Parameter id="g7-6l0yBZEq9U-a4EZjLUw" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="4.5E-08" displayUnit="µm" />
-                  <Parameter id="Gtj-jCBr2UiRvi91JgVnpw" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.051" />
-                  <Parameter id="ueZS7l61gEOuIM4zQilv5A" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.11" />
-                  <Parameter id="M1SinE4S7UeC6WDwxD9U0w" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.039" />
-                  <Parameter id="uYv4GnccGEyk3ooC9qVhMQ" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0565" />
-                  <Parameter id="EK-IpTeqCkuQ2diZgsbjNQ" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.081" />
-                  <Parameter id="lgrdN7PHlEyR22_v37qqSw" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.77" />
-                  <Parameter id="KPAP8fduEEmI-UqAWrOfqQ" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-                  <Parameter id="Q0sIk_LhU0KxWFHWGlgn2Q" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.808" />
-                  <Parameter id="fbplvI-tsUy4zZ3Eh5LFow" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.048" />
-                  <Parameter id="rPLqZtLidUKivj9Hxd1fZw" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.041" />
-                  <Parameter id="JqKKD58gu0aGOZEeS209VQ" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.004" />
-                  <Parameter id="Bj6ab8H6eEKnWjBJticpvQ" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0391" />
-                  <Parameter id="HrNakzJLq0OmakNUXeQ4iQ" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0429" />
-                  <Parameter id="XgIRvdEf2kyThRa5gTO1bQ" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0015" />
-                  <Parameter id="2bG3EdVNu0qwMq3NJsIWKw" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0528" />
-                  <Parameter id="Br1tGXbdxkKxXFb6e52fwg" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.08" />
-                  <Parameter id="kjlmkQWYFUCtv1bU9g8oVA" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.162" />
-                  <Parameter id="IKsI26iLr060doKzi_7LyA" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.591" />
-                  <Parameter id="ESRo9Knyc0mt3tyd1ijoPg" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.79" />
-                  <Parameter id="9S0wQF7hREiBSTIkzanc4Q" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.4" />
-                  <Parameter id="kMnCYjLkMUSIzTHClIlo8w" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0143" />
-                  <DistributedParameter id="uNN_Mg4gaEGEnG1u3pIs6Q" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="BBLlW0uIRUGzSS_KEbyTbg" mode="Logical" visible="1" displayUnit="l">
-                    <Children>
-                      <Parameter id="EuI_1KdCU026bVnWPjT-Pw" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.501934930268944" displayUnit="l" />
-                      <Parameter id="YXMNq-sEj0Cd5YkpfRvaTg" name="Mean" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" value="1.5088" displayUnit="l" />
-                      <Parameter id="J2s59nOgXEO5tt8XuHd5Fw" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" value="0.07544" displayUnit="l" />
-                    </Children>
-                  </DistributedParameter>
-                  <DistributedParameter id="2GzuVTQaV0m31KiQXdfSSQ" name="Specific blood flow rate" description="Blood flow rate normalized to the organ volume" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" formula="P8yWDs2VXkqKpDbbuAHuBA" mode="Logical" visible="1" displayUnit="ml/min/100g organ">
-                    <Children>
-                      <Parameter id="Egx_h9wOwk-R0zhbRDBSAw" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" displayUnit="ml/min/100g organ" />
-                      <Parameter id="qDXg4oYtJEKIX4yd15PXAA" name="Mean" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" visible="0" canBeVaried="1" value="0.51675" displayUnit="ml/min/100g organ" />
-                      <Parameter id="8Qzy3NwM5EKt4-6c_BmbsQ" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0258375" displayUnit="ml/min/100g organ" />
-                    </Children>
-                  </DistributedParameter>
-                  <Container id="DF7RMcQS5kelas00ZZs78w" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Brain" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="vpqYj8d2SkWMd4inhm107w" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="FznSmmCzkUu0ineaazHsfQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Container id="g3Ahvoo-GEy320ZDNZOiRA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                        <Children>
-                          <Parameter id="GhaCjD_sCEu6Ma3Bjel0qg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" visible="0" canBeVaried="0" />
-                          <Parameter id="5_UQu8ZSp0mjgULgnrrpVQ" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                        </Children>
-                      </Container>
-                    </Children>
-                  </Container>
-                  <Container id="-hzUSP0H0UKYFyzMVYcHLg" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Brain" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="28pi619PW0e4IMxlz7UKSg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="SUzWVkoiAkCqrLECP76YFg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Container id="y7pUV7pVn0OutcWPUPx2Zw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                        <Children>
-                          <Parameter id="m2k-4sE43EmK13Lr-LZwww" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                          <Parameter id="o6S3UvaWWkiUxtdAaPHvJw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" visible="0" canBeVaried="0" />
-                        </Children>
-                      </Container>
-                    </Children>
-                  </Container>
-                  <Container id="25_Mxy04OkmI2F3SSIcweg" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Brain" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="vF6Z3oagjEavYzw3Aut07Q" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="wNGrGtmfGEePLINRQumyzg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Parameter id="VkzGtuTAfUqnDNSDLGEQXA" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_pH_INT" visible="1" canBeVaried="1" />
-                      <Container id="SiYQSJav_0-8wYGuC_eKNQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                        <Children>
-                          <Parameter id="qH_FdVjUUE6pKdcAlIuo0Q" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                          <Parameter id="o_t8zODSS0eTCAxkLkezWA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_brn" visible="0" canBeVaried="0" />
-                        </Children>
-                      </Container>
-                    </Children>
-                  </Container>
-                  <Container id="c_MXK797hEu3FFPNqIuxqA" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Brain" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="2tBObQSzO06BUI2izF7rKg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="HkmQNalDxkmZUCeW_EZBnw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Parameter id="NgYT-MinuEeImcxb76COzw" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.1" />
-                      <Container id="cE214kQokU-5VWWNHglyRQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                        <Children>
-                          <Parameter id="Yw5OFU-rdkqQKiYcl-oudQ" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                          <Parameter id="VTFIu5hIDUOQVBNoJ6HlNQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_brn" visible="0" canBeVaried="0" />
-                        </Children>
-                      </Container>
-                    </Children>
-                  </Container>
-                </Children>
-              </Container>
-              <Container id="3Ca8_d1pk0Slo8KZgKFTJA" name="Fat" description="Fat" icon="Fat" mode="Logical" containerType="Organ">
-                <Tags>
-                  <Tag value="TissueOrgan" />
-                </Tags>
-                <Children>
-                  <Parameter id="M5l30bsppk2EIQ4JRzFL8w" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="Individual_PKSim.PARAM_Tissue_Weight" visible="0" canBeVaried="1" displayUnit="kg" />
-                  <Parameter id="csO12F9IlkG4BcNnYKiNuA" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate_Fat" visible="1" canBeVaried="1" displayUnit="l/min" />
-                  <Parameter id="QAadygNxhkGi6T6Ok_tGzQ" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Lymph_flow_rate_Fat" visible="1" canBeVaried="1" displayUnit="l/min" />
-                  <Parameter id="hcwxhH3_4E-c71eYtto25g" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="VascularEndoVolume.VOLUME_VascularEndo_fat" visible="1" canBeVaried="0" displayUnit="l" />
-                  <Parameter id="Q6dFY7rtYU-eeMix3lyN_w" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_f_cell" visible="1" canBeVaried="1" />
-                  <Parameter id="35bpohQN9E--pGe1VxMU3A" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Q_from_Qspec" visible="1" canBeVaried="1" displayUnit="l/min" />
-                  <Parameter id="nNR6sahrHky6zS-8WTIQNg" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                  <Parameter id="hvX-ebbQkEasVrcGp7cuaw" name="Peripheral blood flow fraction" description="Blood flow fraction in organ used for calculation of peripheral venous blood concentrations" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" visible="1" canBeVaried="1" value="0" />
-                  <Parameter id="oVrAlF40lkuqnYLFTnp8qQ" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="2" />
-                  <Parameter id="B4wFAhQeQkekF94PbDsoNQ" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                  <Parameter id="ANDaoxz2IUKte-229nhXqg" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="2.5E-07" displayUnit="µm" />
-                  <Parameter id="P9Q-HIGpn0mlfsIWhXlzGw" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.05" />
-                  <Parameter id="2eTgbnqsM0Kduwq-Pozw6A" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" visible="1" canBeVaried="1" value="4.16666666666667E-12" displayUnit="ml/min/N" />
-                  <Parameter id="zzWg3fQbGkqsEjERXthp5A" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="4.5E-08" displayUnit="µm" />
-                  <Parameter id="gf8--Z-HXUSlMp1cnOUTNg" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.018" />
-                  <Parameter id="q0ZvFNNke0yHiLNctLtobg" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.05" />
-                  <Parameter id="8wVw0N8Ux0Sh10QufPP75A" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.068" />
-                  <Parameter id="xxr_xoXyPUWPKywm_cd2wA" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.049" />
-                  <Parameter id="AB7lgnqZ0UuXqfkHpgI8sg" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0" />
-                  <Parameter id="wsOhgIOopkuffgBYrqiyhQ" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.06" />
-                  <Parameter id="l6vPBnUS002PpHMR8IkMgA" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.4" />
-                  <Parameter id="6D62AALCMUWr9OhUdRiaRw" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.000552" />
-                  <DistributedParameter id="2didNNrQ7UeSGI58gwbA6w" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="rMdtikJs7EutBRJy4COPQg" mode="Logical" visible="1" displayUnit="l">
-                    <Children>
-                      <Parameter id="W-N1CtlXIEGs29vEtFXcjQ" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.489059629117061" displayUnit="l" />
-                      <Parameter id="e53TzNJoIUaytUJgRyZq9g" name="Mean" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" value="12.90800272" displayUnit="l" />
-                      <Parameter id="6yrc4TzT5E2s6FzQLl3iwQ" name="GeometricDeviation" description="Geometric standard deviation of LogNormal distribution" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1.5" />
-                    </Children>
-                  </DistributedParameter>
-                  <DistributedParameter id="w57fKFOa4UqHd59kjYzWKw" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="hqBCapFM1UGguLxHYJVa6A" mode="Logical" visible="1">
-                    <Children>
-                      <Parameter id="BF-RGlx0m0aEJkrGEaXb5g" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                      <Parameter id="Y1FqzOM_lEW1duOGArY39g" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.8" />
-                    </Children>
-                  </DistributedParameter>
-                  <DistributedParameter id="o7hPxRnr-EiEtuN3mjAkuQ" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="F9RIHC6AF0mX_l73piUBbQ" mode="Logical" visible="1">
-                    <Children>
-                      <Parameter id="Cdb8-eZsFE-OdXCr4ItnCQ" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                      <Parameter id="VS4n53clkEeeNNF4d61CIg" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.79" />
-                    </Children>
-                  </DistributedParameter>
-                  <DistributedParameter id="u0IeFwze1ESG-mgJ-pVdaQ" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="YjNztcDZbkidwTTj7Q3SRw" mode="Logical" visible="1">
-                    <Children>
-                      <Parameter id="P8aUzpX2wUGcMt6Ynwfjfw" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                      <Parameter id="cq0wzPZIiUur5Puz1y0kVQ" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.002" />
-                    </Children>
-                  </DistributedParameter>
-                  <DistributedParameter id="t1gUCH-agEusVDTlwl2ihQ" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="5yHmWqIAr0GS1oQ1C-FCqg" mode="Logical" visible="1">
-                    <Children>
-                      <Parameter id="8I4BzvVvrUWayBodpNgwEw" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                      <Parameter id="KOqHOVUiM0aoH_73_33Crw" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.16" />
-                    </Children>
-                  </DistributedParameter>
-                  <DistributedParameter id="OyNajD8RO0W_DEt-r4pGlg" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="iVhaR6qEwkO89jGuDv8c4A" mode="Logical" visible="1">
-                    <Children>
-                      <Parameter id="Epwow-boakqf2qzhjxKbjQ" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                      <Parameter id="xonz60Rkb0yVQJAcLo2iXw" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.18" />
-                    </Children>
-                  </DistributedParameter>
-                  <DistributedParameter id="4AzZ2WEzo0qFjCtkUn3Z5w" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="d9PK9YENQku17Tv3eOF8dg" mode="Logical" visible="1">
-                    <Children>
-                      <Parameter id="oc6W49R3GEOmpVWvaMy9bQ" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                      <Parameter id="3MYnE_PR7EyqncBpcZvUCg" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.15" />
-                    </Children>
-                  </DistributedParameter>
-                  <DistributedParameter id="EPqYYTirgU6-W9OXtuanpw" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="f1eKk-s09kGhNy9Wzjr04A" mode="Logical" visible="1">
-                    <Children>
-                      <Parameter id="O2JKUQ3gJ0-q5NU5aO14Mw" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                      <Parameter id="SXJdepHstUKwk3PKxOHEuQ" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.92" />
-                    </Children>
-                  </DistributedParameter>
-                  <DistributedParameter id="bqsk1QsXNkOGFq6S7A5__g" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="YgNEf-yFNUaOVrFoh4So1Q" mode="Logical" visible="1">
-                    <Children>
-                      <Parameter id="tuGla1IudESzQnrquMww3g" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                      <Parameter id="XyxQlJXYC06-Cb-7dRkvoQ" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.853" />
-                    </Children>
-                  </DistributedParameter>
-                  <DistributedParameter id="ThHkLpwbLE6wxk9eHHu2cw" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="fx2snSwdek6nlGS-YREyRA" mode="Logical" visible="1">
-                    <Children>
-                      <Parameter id="wsqDoZAP0UmGe4y9rzq2qw" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                      <Parameter id="ote5drPprkSA4gW3pKHmrQ" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.002024" />
-                    </Children>
-                  </DistributedParameter>
-                  <DistributedParameter id="EH0pWCd-MESl83BUDq0Mig" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="unN-dDSyqUS7_pEwdhsjzw" mode="Logical" visible="1">
-                    <Children>
-                      <Parameter id="s-Q4mnkIXUqsCx34nZAaOA" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                      <Parameter id="IcaduqU-bkKLxqN_xC3t6Q" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0016" />
-                    </Children>
-                  </DistributedParameter>
-                  <DistributedParameter id="D72mZRORSUeMuYkziHmLwg" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="LJoBvaYl6UKHVJKA-t3ABA" mode="Logical" visible="1">
-                    <Children>
-                      <Parameter id="kpojh6OgcUOLkyiHj7bd8g" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                      <Parameter id="BcHelOyyhkGXgD_IQfEeBA" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.135" />
-                    </Children>
-                  </DistributedParameter>
-                  <DistributedParameter id="pFxxm4iKdU-JrZSqRNg3Rg" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="UIFIvyKpwkWZLpPNZR7ycQ" mode="Logical" visible="1">
-                    <Children>
-                      <Parameter id="63L6SnjXrkOrtiiu97G6JQ" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                      <Parameter id="qJ2OuwbbkkCuYUPvq-jzIA" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.00899999999999998" />
-                    </Children>
-                  </DistributedParameter>
-                  <DistributedParameter id="vxMHzInHlEiyZU4utNA7ww" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CTDGZSxY1ker2HSFsMBjWg" mode="Logical" visible="1">
-                    <Children>
-                      <Parameter id="4hL8TX8lwkezXO9oob_wkA" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                      <Parameter id="LvligyvuZ0KAj_nG3QN-VQ" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.03" />
-                    </Children>
-                  </DistributedParameter>
-                  <DistributedParameter id="D3gRib-xy0yVrDzSLQTanQ" name="Specific blood flow rate" description="Blood flow rate normalized to the organ volume" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" formula="akpIA4gEe0Ox1FRJ2gaQeA" mode="Logical" visible="1" displayUnit="ml/min/100g organ">
-                    <Children>
-                      <Parameter id="xr0iUhrZcEmJu1xC1g-B6Q" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" displayUnit="ml/min/100g organ" />
-                      <Parameter id="E-2POtPjOEWxuIEhesS5PQ" name="Mean" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" visible="0" canBeVaried="1" value="0.02184" displayUnit="ml/min/100g organ" />
-                      <Parameter id="CCvXTD12BEiR5OH0w15m0w" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" visible="0" canBeVaried="1" value="0.001092" displayUnit="ml/min/100g organ" />
-                    </Children>
-                  </DistributedParameter>
-                  <Container id="T_1TMJYsE0yHE_9nhhc74Q" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Fat" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="3B4hfskURUC3RNwgDwdIJQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="v7hWOLFt6kuM5gfFwJhKiA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Container id="Dm3x7M7ypU6QC1OveoHUGA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                        <Children>
-                          <Parameter id="vqzfGjlQJU62i4xYUF7Yjg" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                          <Parameter id="n8hg8Rc8YkynZn7LNFAHdA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" visible="0" canBeVaried="0" />
-                        </Children>
-                      </Container>
-                    </Children>
-                  </Container>
-                  <Container id="x2EBR2z3O02CQY3uNWAaxQ" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Fat" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="OoXDowsOCkiEETI0M1GuPA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="3AtxvEE3MEmWsk0DoPMDGA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Container id="AXyHJrrBp0ygxC4rE7wTYw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                        <Children>
-                          <Parameter id="hZ0BZlsxSUKey4Wpp1IbFA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                          <Parameter id="PhwbHxH-i0qMbf44DYu08w" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" visible="0" canBeVaried="0" />
-                        </Children>
-                      </Container>
-                    </Children>
-                  </Container>
-                  <Container id="uQu41YcHdk2JY4jt_EwoQA" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Fat" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="NgMCcSPYwE6JQ430pfFzZQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="Jil0gdBUUUGT3ovFvb8fBw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Parameter id="FHO_4tkVIUeRgVBXD7ckww" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_pH_INT" visible="1" canBeVaried="1" />
-                      <Container id="FcJX7HhmJES3h-e8EumhUw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                        <Children>
-                          <Parameter id="7PXGpZcoLkyzlGLzpqMMIA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                          <Parameter id="6SdxMFPbHk-xZzvwMxMUtQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_fat" visible="0" canBeVaried="0" />
-                        </Children>
-                      </Container>
-                    </Children>
-                  </Container>
-                  <Container id="VDtCW9Mz2UK58etDrlERew" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Fat" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="UW_pFvve30aDatty7OCVdg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="DVqIOT4R8ESl-wUlqrUKxQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Parameter id="TyOJn_l7zE6cGHyfEwqUHA" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.1" />
-                      <Container id="EBxhThqJLkO_WoYJ5yo3sA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                        <Children>
-                          <Parameter id="h_nnqVi0Zk2p4Lx52WddmA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                          <Parameter id="sx-XfZ72lkS7YQ7PQzaOhg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_fat" visible="0" canBeVaried="0" />
-                        </Children>
-                      </Container>
-                    </Children>
-                  </Container>
-                </Children>
-              </Container>
-              <Container id="JXe0Cdkui0Oz7XJfrmgKSA" name="Gonads" description="Gonads" icon="Gonads" mode="Logical" containerType="Organ">
-                <Tags>
-                  <Tag value="TissueOrgan" />
-                </Tags>
-                <Children>
-                  <Parameter id="vIXwn8ZY7U-0MlBGMWUw_Q" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="Individual_PKSim.PARAM_Tissue_Weight" visible="0" canBeVaried="1" displayUnit="kg" />
-                  <Parameter id="CmVbGsIJBkSzbKEZ3Lv8JQ" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="VascularEndoVolume.VOLUME_VascularEndo_tes" visible="1" canBeVaried="0" displayUnit="l" />
-                  <Parameter id="eH-w-bWoqEa5yk9Y-bMdHA" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Lymph_flow_rate_Gonads" visible="1" canBeVaried="1" displayUnit="l/min" />
-                  <Parameter id="Q7U1xQI9t0OUw9x9MDgxug" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate_Gonads" visible="1" canBeVaried="1" displayUnit="l/min" />
-                  <Parameter id="4yLzuJkO5kSpoJjmgL-TdA" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_f_cell" visible="1" canBeVaried="1" />
-                  <Parameter id="t4-QvfXxtEeYrCu4uHrqlw" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Q_from_Qspec" visible="1" canBeVaried="1" displayUnit="l/min" />
-                  <Parameter id="ebuJtdwTWEm0v9405pOFTg" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                  <Parameter id="uH45bRp8RUm67gyVxXfxjQ" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.75" />
-                  <Parameter id="Ub53UnkaUUmSCZKxpfZnAA" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                  <Parameter id="EESG578dVUup9ANntI38GQ" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="2.5E-07" displayUnit="µm" />
-                  <Parameter id="d4bmWabUVUWfcm0ITrz9yg" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" visible="1" canBeVaried="1" value="1.66666666666667E-12" displayUnit="ml/min/N" />
-                  <Parameter id="iDWQOV6rBEanXhY7l8OT5Q" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.05" />
-                  <Parameter id="vmhEUGR1WUeHyJyRbqPvDg" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="4.5E-08" displayUnit="µm" />
-                  <Parameter id="wxR4Qhyp-E-M79ZfSGKoHA" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.031" />
-                  <Parameter id="Zhp0_DkNy0yrtWqYnE_kcQ" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0048" />
-                  <Parameter id="di3C4uzGyUOjh2DqsnpkKQ" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.055" />
-                  <Parameter id="8RKeNZHKFEOamJ9Ee6DHOQ" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.12" />
-                  <Parameter id="rNFYd4GqbEulYkOa1fwPqg" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.01405" />
-                  <Parameter id="oyMi9UVCbUy1j-cJcF6NhQ" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.048" />
-                  <Parameter id="KZBI0iTYuE2ufBE9i5nu_w" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.041" />
-                  <Parameter id="F05AvMZKika6LtGp3rw9xw" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-                  <Parameter id="mX2goQ_yykOHJKY2Iqy2GQ" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.8" />
-                  <Parameter id="q4IYM_4uQ0aeqzxWcztk7g" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.8" />
-                  <Parameter id="Hq8D7wlRc0-HSkaEhmq5-A" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.069" />
-                  <Parameter id="iUAIHRlXO0e0SQmti7U-hw" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0" />
-                  <Parameter id="U0CTQ8cIDkGZ-mSMiXDBww" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0048" />
-                  <Parameter id="WWh9qNcoXUOwudAfA-SImQ" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0116" />
-                  <Parameter id="nFvuyrN6SEe9RPpzXiPUHg" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0249" />
-                  <Parameter id="jUfsB_ZOnkSbm5UoVSGm4w" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.13" />
-                  <Parameter id="-EMJD7FXT0KcBS4uLPF_zw" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.03" />
-                  <Parameter id="ltfbkXRFwkijx-SU6ETBXA" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.83" />
-                  <Parameter id="AVZlLLIHWEG2udq4onPBug" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.78" />
-                  <Parameter id="XgUm5SFo9USlJVnYD3sUXw" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0054" />
-                  <Parameter id="-IRhxv8dZ0uvo70OEsV9Ng" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="2.45" />
-                  <DistributedParameter id="gCDA0jugWkOaEGqgpYMZRw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="mSj40SQyuk2DMn7sGyBJRg" mode="Logical" visible="1" displayUnit="l">
-                    <Children>
-                      <Parameter id="aiUJVPLDx02aHzFHuhj1Wg" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.49986860203947" displayUnit="l" />
-                      <Parameter id="epk90f4Mb0ySnFyPR5iAqQ" name="Mean" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0324411260176448" displayUnit="l" />
-                      <Parameter id="tFrkfPfwKUiv0k_4jXL1jA" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" value="0.00162205630088224" displayUnit="l" />
-                    </Children>
-                  </DistributedParameter>
-                  <DistributedParameter id="h4OQGC7Tu0GA7b4UU9R54g" name="Specific blood flow rate" description="Blood flow rate normalized to the organ volume" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" formula="cj-TAhD3LEaDVgX74HalTw" mode="Logical" visible="1" displayUnit="ml/min/100g organ">
-                    <Children>
-                      <Parameter id="94lpVW57REu2HREAfEiYSg" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" displayUnit="ml/min/100g organ" />
-                      <Parameter id="f_zxccdI0kOT6ey7uwcwqA" name="Mean" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0806" displayUnit="ml/min/100g organ" />
-                      <Parameter id="cqNLAuXqF0qRaoDn5jp6aA" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" visible="0" canBeVaried="1" value="0.00403" displayUnit="ml/min/100g organ" />
-                    </Children>
-                  </DistributedParameter>
-                  <Container id="WeKcMw4iF0S7FmaFEOg7rA" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Gonads" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="rVjz_sgbHU6Uviz-n0Xr9w" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="RJ0r4R_dEUeb46kSIqXgrA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Container id="k6udlQ5O6kqNuAjW1ak82A" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                        <Children>
-                          <Parameter id="_cvJ8lLloEaFlvT7qoMomg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" visible="0" canBeVaried="0" />
-                          <Parameter id="p4ARvq5ByE-z8nwyxfJkYA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                        </Children>
-                      </Container>
-                    </Children>
-                  </Container>
-                  <Container id="lJHKHjIq9ESo-oG4BuGNgQ" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Gonads" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="IcnXiPZCDU6KB8-L1KSqFA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="MVY-BKt-aUKFpKoVXAOqWw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Container id="wci1-tFVEU65OLAVXkgMFw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                        <Children>
-                          <Parameter id="bggfJ07EOES0fjBeDXBacg" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                          <Parameter id="OszMQPMcgk-25DqlmV0_jw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" visible="0" canBeVaried="0" />
-                        </Children>
-                      </Container>
-                    </Children>
-                  </Container>
-                  <Container id="1IHG4DNKOUePTVwBu4nQrw" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Gonads" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="6ITfvf2u4EyxniMHKFDfCw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="bXvm96igX02YWTfokpBl8Q" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Parameter id="jDdmj1cmSEajhJ7yoT1F2Q" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_pH_INT" visible="1" canBeVaried="1" />
-                      <Container id="VEwmdTXIN0uEYIp0cu3wog" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                        <Children>
-                          <Parameter id="ncaCr2Tv0EOt4mH7YuIkWw" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                          <Parameter id="5OP5H364MEO9zee-4Qo1Qg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_tes" visible="0" canBeVaried="0" />
-                        </Children>
-                      </Container>
-                    </Children>
-                  </Container>
-                  <Container id="RR9zSg1yNUKN633IoKuRDw" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Gonads" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="8-qoiNTqu0mriib7kYe9hA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="pCG7LWjaOk-COiDCm7fweQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Parameter id="NjrJS7osO0agNhfQWgyRSg" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7" />
-                      <Container id="Vo1DBVHlx0m8BtyBGWmR-g" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                        <Children>
-                          <Parameter id="ptBFh3sdjEG8uD9_X98DSA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_tes" visible="0" canBeVaried="0" />
-                          <Parameter id="_nlP9o08yE2Q8aN_mtkt5A" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                        </Children>
-                      </Container>
-                    </Children>
-                  </Container>
-                </Children>
-              </Container>
-              <Container id="pgmTt6HfKUazKkVva3DmQw" name="Heart" description="Heart" icon="Heart" mode="Logical" containerType="Organ">
-                <Tags>
-                  <Tag value="TissueOrgan" />
-                </Tags>
-                <Children>
-                  <Parameter id="rIDqUuTdHka88jqzrY03XQ" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="Individual_PKSim.PARAM_Tissue_Weight" visible="0" canBeVaried="1" displayUnit="kg" />
-                  <Parameter id="Go846w-spk2Ab-l3C6nkcw" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="VascularEndoVolume.VOLUME_VascularEndo_hrt" visible="1" canBeVaried="0" displayUnit="l" />
-                  <Parameter id="WIXEKMVenkqfISsODqTmvg" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Lymph_flow_rate_Heart" visible="1" canBeVaried="1" displayUnit="l/min" />
-                  <Parameter id="RONrMK4Tpk2LQwQUIcjfkg" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate_Heart" visible="1" canBeVaried="1" displayUnit="l/min" />
-                  <Parameter id="ix6QowhyzU-BYJZGdSlSig" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_f_cell" visible="1" canBeVaried="1" />
-                  <Parameter id="J8sbiFQAQkqAxP0kvZwX9g" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Q_from_Qspec" visible="1" canBeVaried="1" displayUnit="l/min" />
-                  <Parameter id="rVCicPcnMECfcmH79lDx2g" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                  <Parameter id="0ExBDqXPCEOx7HtM6na-aQ" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.75" />
-                  <Parameter id="mser-3Rz9UarobSd6Oy_Ug" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                  <Parameter id="hwo2FLAeF0SMoH6mzXtzDQ" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="2.5E-07" displayUnit="µm" />
-                  <Parameter id="KCO3unu7SUKe1g14iTqfFQ" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.05" />
-                  <Parameter id="TJI_KMfBwEWU3E4zZ64T1w" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="4.5E-08" displayUnit="µm" />
-                  <Parameter id="Uhlt0Lxt9EWnQm-4hpxOvA" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" visible="1" canBeVaried="1" value="1.43333333333333E-11" displayUnit="ml/min/N" />
-                  <Parameter id="Ys6-IVt0hUae0hEjj4IsCw" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.1" />
-                  <Parameter id="tVEF8idc70aTd8MQTUpxVw" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0115" />
-                  <Parameter id="U0ERYz56AUWJADVQY4uj4A" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.14" />
-                  <Parameter id="j8T_mCZj0UupW2JZZDhDZw" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.168" />
-                  <Parameter id="PQ3k1P9DEUCKRaCcFqRxpg" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0166" />
-                  <Parameter id="q18ZYhiw0kOgn95nW4PtPQ" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.157" />
-                  <Parameter id="CSrTYofoHUuFnbf6crVlzw" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-                  <Parameter id="mlaYnQgaL0if1te8s0cXsQ" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.16" />
-                  <Parameter id="KyisRonVAEODtC7yY99yuw" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.731" />
-                  <Parameter id="OwRVcRYB0EagKd3CpKLH5A" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.758" />
-                  <Parameter id="NF4PRAbzZkO3I7F6DWO7eg" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.1" />
-                  <Parameter id="FdSRZQUWjkOJeMsQ1C0F0g" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0135" />
-                  <Parameter id="kk7rWFKxVEenOSZ9gVtS5A" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0528" />
-                  <Parameter id="FBSEOlXbi0S3uwKZrIvcpA" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0473" />
-                  <Parameter id="jSyQ7Hw0EkyY108e_4s-Qw" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0106" />
-                  <Parameter id="bEfMNDHupkm22YL3nblQ8Q" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.32" />
-                  <Parameter id="AgBvma20zkKCzhtwtAz0Iw" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.19" />
-                  <Parameter id="dZy-lSLFqU26q24nWRUHZw" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.248" />
-                  <Parameter id="MIzE6qXT4k6Gj2SojNMd2A" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.7" />
-                  <Parameter id="hMAgi-EtZkuVLJXIOHZ_qQ" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0099" />
-                  <Parameter id="aM8h7FCJrke1tK2420oJJg" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="2.25" />
-                  <DistributedParameter id="w_jQ1Zb6L0eBwnkoQUHlvA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="19bmYtinX0iphVaTkyR4eg" mode="Logical" visible="1" displayUnit="l">
-                    <Children>
-                      <Parameter id="TMfBSgiVx0O6vcstDyWz-w" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.501686042726849" displayUnit="l" />
-                      <Parameter id="CbThZQfXoEqXIAEPfHilNg" name="Mean" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" value="0.33610750955904" displayUnit="l" />
-                      <Parameter id="vUnttr-4XEuGIFx9LYN--w" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0644491961210393" displayUnit="l" />
-                    </Children>
-                  </DistributedParameter>
-                  <DistributedParameter id="9CQU3DGQBkCTVNd5XXs3FQ" name="Specific blood flow rate" description="Blood flow rate normalized to the organ volume" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" formula="k_YZJk-8HE-Q5Eb1M2MhwA" mode="Logical" visible="1" displayUnit="ml/min/100g organ">
-                    <Children>
-                      <Parameter id="usBP-FBmVES6PrwrgZrcCg" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" displayUnit="ml/min/100g organ" />
-                      <Parameter id="Muq9h0oHLESIl1b4ot7saA" name="Mean" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" visible="0" canBeVaried="1" value="0.62335" displayUnit="ml/min/100g organ" />
-                      <Parameter id="1sXbOEVJfUyoeRuMVSIB3w" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0311675" displayUnit="ml/min/100g organ" />
-                    </Children>
-                  </DistributedParameter>
-                  <Container id="8FF9S5dtNES_fI7J-tqAmQ" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Heart" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="nWe_73oazkyBZNA4iCXDCw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="gFiZq_J13EaghZPBBTnkmw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Container id="dkPR59sf20yp5WyhUuO_Jw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                        <Children>
-                          <Parameter id="yD9U10Hy8kG3U4_GzIipDA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" visible="0" canBeVaried="0" />
-                          <Parameter id="A8TYXwGNt0qxYiSUThbXeQ" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                        </Children>
-                      </Container>
-                    </Children>
-                  </Container>
-                  <Container id="2ChqB3XlJECSWoT4xWUL4g" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Heart" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="eFBM8DdCSEKjQv_nPZRi6Q" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="H94p5wqHxkiiv3O9GoZqGg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Container id="NS74tVcs90yET24H4AUgQA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                        <Children>
-                          <Parameter id="PEyufYamnUK-Ci6IQeBAbQ" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                          <Parameter id="LHgkgxyqyU22ypBP8rRu6w" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" visible="0" canBeVaried="0" />
-                        </Children>
-                      </Container>
-                    </Children>
-                  </Container>
-                  <Container id="_MdcEmv4h0Gvl-1SRpASXg" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Heart" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="Ei40ijCK_E2wZ1kkKQy7ug" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="p7x6oV3ARE-fE64aD8Pz2w" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Parameter id="X7rXFWnKmUa9XZcdPLyS2A" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_pH_INT" visible="1" canBeVaried="1" />
-                      <Container id="5XSOJSl-6UqHOD-qvW0DSg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                        <Children>
-                          <Parameter id="hdJP9cv-lUGHk4f5IToQmA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                          <Parameter id="M5XUJiglb0KV3eUFYyQwGA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_hrt" visible="0" canBeVaried="0" />
-                        </Children>
-                      </Container>
-                    </Children>
-                  </Container>
-                  <Container id="VCB9eB3pKUCP3lOkO16geQ" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Heart" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="7WSl51LXpEaWEObqq3yvjw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="gRifxgXMHkunDWx9T1trTQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Parameter id="zaFszGwVV02ma0FjiNXIRg" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.1" />
-                      <Container id="oEtllhPT60uj2Sp5s8VHBQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                        <Children>
-                          <Parameter id="UOD-Q6VQukWN2aY5dGamow" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_hrt" visible="0" canBeVaried="0" />
-                          <Parameter id="fGvA4FHwik22VaTAHkUjRA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                        </Children>
-                      </Container>
-                    </Children>
-                  </Container>
-                </Children>
-              </Container>
-              <Container id="ytN9kAppAUqGM87pofblMA" name="Kidney" description="Kidney" icon="Kidney" mode="Logical" containerType="Organ">
-                <Tags>
-                  <Tag value="TissueOrgan" />
-                </Tags>
-                <Children>
-                  <Parameter id="Tl_ax_mw6kmsLmljWQ8b5Q" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="Individual_PKSim.PARAM_Tissue_Weight" visible="0" canBeVaried="1" displayUnit="kg" />
-                  <Parameter id="_sPWZsYu4EyCQ9hjDK8v1w" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="VascularEndoVolume.VOLUME_VascularEndo_kid" visible="1" canBeVaried="0" displayUnit="l" />
-                  <Parameter id="cnGm8MiTc0ODGlADMNe6HQ" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Lymph_flow_rate_Kidney" visible="1" canBeVaried="1" displayUnit="l/min" />
-                  <Parameter id="QFaxidVv_keS10IsgRQErA" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate_Kidney" visible="1" canBeVaried="1" displayUnit="l/min" />
-                  <Parameter id="3HGCUnzBpUCjk9MgvmRqcQ" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_f_cell" visible="1" canBeVaried="1" />
-                  <Parameter id="X-Cv2ERGq0qERwcvRQurWw" name="GFR (specific)" description="Glomerular filtration rate normalized to the volume of the kidney" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" formula="GFR_Calculation.PARAM_GFR_Spec" visible="1" canBeVaried="1" displayUnit="ml/min/100g organ" />
-                  <Parameter id="IL9HhGpfBEKQH_maRhWMaQ" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Q_from_Qspec" visible="1" canBeVaried="1" displayUnit="l/min" />
-                  <Parameter id="GLgsGB0vEE-u06TzJ40RFg" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                  <Parameter id="-wFw7EJLzk-xYcVmGmQflw" name="Volume (standard kidney)" description="Volume (standard kidney)" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="0" value="0.44" displayUnit="l" />
-                  <Parameter id="Ye1DsP0xV0qV7uPbWoKx6g" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.75" />
-                  <Parameter id="gwh8M8WUeUKaJufZcLTNiw" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                  <Parameter id="ZTOYs3HXgk-kcVhbf22dbw" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="4.5E-08" displayUnit="µm" />
-                  <Parameter id="cUA1zwlldki0T8pED7R4eQ" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="2.5E-07" displayUnit="µm" />
-                  <Parameter id="6Xyv5rEooEOAkDAzevNCaQ" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" visible="1" canBeVaried="1" value="1.53888888888889E-10" displayUnit="ml/min/N" />
-                  <Parameter id="mTaGa7gV6U-Eng1B3G_Yfw" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.05" />
-                  <Parameter id="aJ5HIkEp80GiNyDViNMHdg" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0207" />
-                  <Parameter id="NJ9I7y7yg0mlt_XiYEkG-g" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.052" />
-                  <Parameter id="LTKFl6QatkCncwAXNwnCnw" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.23" />
-                  <Parameter id="N4x35veaz06LHNFmyt_4iA" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.171" />
-                  <Parameter id="WIXXvbwkwkqYjkS_bkc6eQ" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0162" />
-                  <Parameter id="b0WbXOYcYEmZ0FvZcrOneA" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.783" />
-                  <Parameter id="GrJESd5sfkSxywJWEIefWw" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-                  <Parameter id="lJyDkGwWDE6GjXw90oOmSg" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.774" />
-                  <Parameter id="ZvHNszF1WUuSrFuqWp4KRw" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.13" />
-                  <Parameter id="_RVglwm-Z0K1V7sJ7pyP9A" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.137" />
-                  <Parameter id="rCUhz2RIBkivpqtIKHR0zw" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.2" />
-                  <Parameter id="qiwdDnM7g0aSr5g5mlzqPw" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0156" />
-                  <Parameter id="s1Kc0rwZ3EKBcKBSE09GEg" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0121" />
-                  <Parameter id="Xe0d-BcqbE6TYxHembz8-Q" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0366" />
-                  <Parameter id="futade0310-VafA03sQOpw" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.024" />
-                  <Parameter id="VuCDavhoxEmvFkO6KmKA_g" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.273" />
-                  <Parameter id="la9KegyivESBoJJ_tBRNQg" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.21" />
-                  <Parameter id="G0insR5CKEq5iBVj33sW1Q" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.73" />
-                  <Parameter id="TZxChkl35UOiNmLisSJLNQ" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.399" />
-                  <Parameter id="iUu5UFbM7EG_WutpxADzzQ" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0078" />
-                  <Parameter id="UxF-Ipl6-0y7l1E4kc0oqA" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="5.03" />
-                  <Parameter id="z5AG60T-UUq_RtP5AmlSVA" name="fGFRpremat" description="Fractional offset in the GFR that corrects for a tendency to slightly underestimate the observed median GFR values in preterm infants below approximately 32 weeks of gestation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.258" />
-                  <DistributedParameter id="hN-jpvBTh06eXTcTFCmwmA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="fBEvJgpNZ0GYRslIyWtAAA" mode="Logical" visible="1" displayUnit="l">
-                    <Children>
-                      <Parameter id="CIlfq98DqkqEvBKkyQVJYA" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.502916506718822" displayUnit="l" />
-                      <Parameter id="zvvlPHAohU6wNCAUbvCDvA" name="Mean" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" value="0.352639181853312" displayUnit="l" />
-                      <Parameter id="fMoHQpsYRkKwY6V_ejnP9g" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0868498798527259" displayUnit="l" />
-                    </Children>
-                  </DistributedParameter>
-                  <DistributedParameter id="Q1XoezWxwkG99mJh86K2ww" name="Hill coefficient for GFR" description="Parameter describing the cooperativity of the process for GFR calculation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="oRqHr5jx4kGpzABvFcijSg" mode="Logical" visible="0">
-                    <Children>
-                      <Parameter id="fZENHpX3vEi7axJuTgi76A" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                      <Parameter id="G8nEdzKk7EyPQyIzwOrbgQ" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="15" />
-                      <Parameter id="c4C5c6v3yES7vRi4oPvZUA" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.257" />
-                    </Children>
-                  </DistributedParameter>
-                  <DistributedParameter id="Swmya6EP1k-N69P2wr2-Xw" name="TM50 for GFR" description="TM50 for GFR calculation" persistable="0" isFixedValue="0" dim="Age in weeks" quantityType="Parameter" formula="ELN3QXxCCkGbWtB1Jvuu8Q" mode="Logical" visible="0" displayUnit="week(s)">
-                    <Children>
-                      <Parameter id="LT1FNfuiAkay-hFHJ7vWEQ" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" displayUnit="week(s)" />
-                      <Parameter id="KsNP1z7GvU6-k519wUa4Yg" name="Mean" persistable="0" isFixedValue="0" dim="Age in weeks" quantityType="Parameter" visible="0" canBeVaried="1" value="44.4" displayUnit="week(s)" />
-                      <Parameter id="pJerQAMZ10G0eMOz-x7shA" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" dim="Age in weeks" quantityType="Parameter" visible="0" canBeVaried="1" value="1.04" displayUnit="week(s)" />
-                    </Children>
-                  </DistributedParameter>
-                  <DistributedParameter id="byoqDbjfhUeTUNebTIzAGg" name="GFRmat" description="Mature value for GFR in a healthy adult individual weighing 70 kg (=117 mL/min)" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="5VZNzNq190WpqRwRg5j12A" mode="Logical" visible="0" displayUnit="l/min">
-                    <Children>
-                      <Parameter id="8zk8XdngRkeyBZntEnd0Jw" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" displayUnit="l/min" />
-                      <Parameter id="NqJ4JL7VUUSnqNvbK1Jsxg" name="Mean" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" visible="0" canBeVaried="1" value="0.11704" displayUnit="l/min" />
-                      <Parameter id="pSAnPgNZ9kGSpf7sQPOx3w" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" visible="0" canBeVaried="1" value="0.026708" displayUnit="l/min" />
-                    </Children>
-                  </DistributedParameter>
-                  <DistributedParameter id="mvGr-5lkg0iPBwy5-5lZeg" name="Specific blood flow rate" description="Blood flow rate normalized to the organ volume" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" formula="QcrwWoSaP0GXOciuA8GiHA" mode="Logical" visible="1" displayUnit="ml/min/100g organ">
-                    <Children>
-                      <Parameter id="0Ebxf5IdmkSsWf9i3q7R7Q" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" displayUnit="ml/min/100g organ" />
-                      <Parameter id="ruUm14-kaUeuSGok_yI53Q" name="Mean" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" visible="0" canBeVaried="1" value="3.02705" displayUnit="ml/min/100g organ" />
-                      <Parameter id="kbVPI-Bm30yDcRTbzbrCBQ" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" visible="0" canBeVaried="1" value="0.1513525" displayUnit="ml/min/100g organ" />
-                    </Children>
-                  </DistributedParameter>
-                  <Container id="vNliK8ccZ0mhuF90e6m6Sw" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Kidney" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="j2_jmKP7ukG093V89b89kQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="DKqvkmUX4EKRxf0aQ5C2Zg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Container id="s3BN8eKvlU-HfhAinsNOLQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                        <Children>
-                          <Parameter id="oe0EqhyQ102KgPm5QfvFwg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" visible="0" canBeVaried="0" />
-                          <Parameter id="tYm_X10ea06DPxVny2FUgQ" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                        </Children>
-                      </Container>
-                    </Children>
-                  </Container>
-                  <Container id="8zPkGeGmU0OEOAd4v6wLwA" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Kidney" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="a3rprXYybkCXsby6VHcJ3A" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="eyYdhtrsJESqM5QbMjQ0cA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Container id="Dem-XTL7ck6eLsQdgqyo6A" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                        <Children>
-                          <Parameter id="GFRluTo7b0WXv9LQmt2jfw" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                          <Parameter id="QxHwR2-2ukSptZz3hZczCw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" visible="0" canBeVaried="0" />
-                        </Children>
-                      </Container>
-                    </Children>
-                  </Container>
-                  <Container id="Lowod1S6EUOQfh9G0nlt1A" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Kidney" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="zsvz8_5zsUafkCUg4QBOHQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="1mhx9dzLl0C1VgRn81GArg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Parameter id="MY7qAdzbrkWrzsbJwl-LXA" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_pH_INT" visible="1" canBeVaried="1" />
-                      <Container id="bfed_QN7OEuyLz_WQ4hlhg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                        <Children>
-                          <Parameter id="b_S-zDbIXUCb7112-hlW0A" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                          <Parameter id="ISEQ8RvHf02M4-0YDxEOsA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_kid" visible="0" canBeVaried="0" />
-                        </Children>
-                      </Container>
-                    </Children>
-                  </Container>
-                  <Container id="eLf8CEl_NUi-dMAposbfrA" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Kidney" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="hZUbH17CakCgMQ8A0Kvodw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="jZrtMc06LEmCWgdZ-2P-dQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Parameter id="oh9L7i5LWE223D7kSZwE7w" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.22" />
-                      <Container id="xHKOT09DOkaMzurNkcqKHw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                        <Children>
-                          <Parameter id="x9C_ASBicUSdYGDHd6L2lQ" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                          <Parameter id="FWYke9HP2kyVfMtFdEnYow" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_kid" visible="0" canBeVaried="0" />
-                        </Children>
-                      </Container>
-                    </Children>
-                  </Container>
-                  <Container id="o6ozB8VQSky3KivzfiFkuQ" name="Urine" description="Urine compartment used to collect the fraction excreted to urine" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Kidney" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="j-6EuUf_3US1St4XlDqbug" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="l" />
-                      <Container id="XQl25cyFq0S5IXyf_70SGg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule" />
-                    </Children>
-                  </Container>
-                </Children>
-              </Container>
-              <Container id="BKKVWIH-skG5wgiURVEmaw" name="Lumen" description="Lumen" icon="Lumen" mode="Logical" containerType="Organ">
-                <Children>
-                  <Parameter id="nurnUq1xCEOJGiiFzEve_Q" name="OralApplicationsEnabled" description="Enables/disables all transports between mucosa and lumen" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="0" value="1" />
-                  <Parameter id="NNwL6zIlbkyLCY2G4EsV4Q" name="Paracellular absorption sink condition" description="Flag for conditions of the environment for paracellular absorption: 1= no sink condition, 0 = sink condition" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="0" value="1" />
-                  <Parameter id="MHsKvxWJIkq1nXODVjXTnw" name="Transcellular absorption sink condition" description="Flag for conditions of the environment for transcellular absorption: 1=no sink condition, 0=sink condition" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="0" value="1" />
-                  <Container id="UmGxOEHQ7kGDntzb_Y39tw" name="Stomach" description="Stomach" icon="Stomach" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Lumen" />
-                      <Tag value="LumenSegment" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="Cvbo6hNpv0GfA8UZZ7L3gA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_LumenSegment" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Parameter id="6mTeAseROUK9Vbjp486AAg" name="Volume (gut wall)" description="Volume of the gut wall" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="MucosaVolume.PARAM_VolumeGutWall" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Parameter id="qs8hZXZ8skSBHqt0Gg8iOA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="pQDrK1qpRkiAVACSg6AYjA" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Lumen_PKSim.PARAM_pH_from_pH_fasted" visible="0" canBeVaried="0" />
-                      <Parameter id="2IPZFUBQ1UmsQ-8JOwuZlw" name="Secretion of liquid" description="Rate of liquid inflow" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Inflow_Stomach" visible="0" canBeVaried="1" displayUnit="l/min" />
-                      <Parameter id="MNjHqAjuh0ezzZRVTEfLwQ" name="Absorption of liquid" description="rate of liquid outflow" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" visible="0" canBeVaried="1" value="0" displayUnit="1/min" />
-                      <Parameter id="5NHr1z-Df0-U6vgU9qTTxw" name="FillLevelFlag" description="Fill Level Flag" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Lumen_PKSim.PARAM_FillLevelFlagFlag" visible="0" canBeVaried="1" />
-                      <Parameter id="n_j8CDHO40OI_VaCdt1EOw" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Lumen_PKSim.PARAM_FillLevel" visible="0" canBeVaried="1" />
-                      <Parameter id="bYWjc5WIUEeeQPdp7AAz_w" name="Geometric surface area" description="Geometric surface area of GI segment" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Area" visible="1" canBeVaried="1" displayUnit="cm²" />
-                      <Parameter id="4YNooxkXGUSoVHDRmdZyRw" name="GET of non-disintegrated moiety" description="The time point at which a solid dosage leaves the stomach and enters the duodenum. Please note that the discrete emptying of a solid dosage form depends on both the physiological properties of the individual and the dosage form." persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" visible="1" canBeVaried="1" value="60" displayUnit="min" />
-                      <Parameter id="FBQXvjW5RESBiBFPNjRZaA" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_InverseGastricEmptyingTime" visible="0" canBeVaried="1" displayUnit="1/min" />
-                      <Parameter id="e_N5EBG6pEyz0OROLhYNeQ" name="Liquid" description="Liquid" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Liquid_StartValue" visible="0" canBeVaried="1" rHSFormula="Lumen_PKSim.LiquidRHS_sto" displayUnit="l" />
-                      <Parameter id="w2Ci4pC2S02wt-tazaVAuw" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Lumen_PKSim.PARAM_LiquidTransferRate_sto" visible="0" canBeVaried="0" displayUnit="l/min" />
-                      <Parameter id="sMWLlW5WI0qFy-fbft6bsQ" name="Inverse rate of inflow of liquid into stomach" description="Inverse rate of inflow of liquid into stomach" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" visible="0" canBeVaried="1" value="15" displayUnit="min" />
-                      <Parameter id="zZ8OFB3pTkK-be2TChveVA" name="pH in fasted state" description="pH in fasted state" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="2" />
-                      <Parameter id="HG_Goh-c40Grjryw7iebWg" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" visible="1" canBeVaried="1" value="0.030169" />
-                      <Parameter id="TWYRCseE2kSxlOnWQ2rRBQ" name="Thickness of gut wall" description="Thickness of Gut Wall" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.022668" displayUnit="cm" />
-                      <Parameter id="dk2Geq_vUUyHsqt-Z3vd4A" name="pH in fed state" description="pH in fed state" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="0" value="5.5" />
-                      <DistributedParameter id="UACvlccEvUykic1CvZXcVw" name="Length" description="Length" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Pp6PIJQC2EO37OPtS-BOcw" mode="Logical" visible="1" displayUnit="cm">
-                        <Children>
-                          <Parameter id="6A5QusCsV06nVSCd6jl8Zg" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" displayUnit="cm" />
-                          <Parameter id="xze1ad3uvk-TasxKL-51HQ" name="Mean" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="2" displayUnit="cm" />
-                        </Children>
-                      </DistributedParameter>
-                      <DistributedParameter id="FsWYLdjcmUSoLx4R7FhDWw" name="GET_beta (Weibull function) variability factor" description="GET_beta (Weibull function) variability factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="cADcyacHNE-qHrJMV4yOYw" mode="Logical" visible="0">
-                        <Children>
-                          <Parameter id="PJadvS-bY0-3gjfgKXco6g" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                          <Parameter id="OlDk2Wy_QkKRfw-aeci0aw" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                          <Parameter id="IJ8kcg5zx02xdfZZ80gwKQ" name="GeometricDeviation" description="Geometric standard deviation of LogNormal distribution" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1.32" />
-                        </Children>
-                      </DistributedParameter>
-                      <DistributedParameter id="KTwPaeMT1kGziedXofLW7Q" name="GET_alpha (Weibull function) variability factor" description="GET_alpha (Weibull function) variability factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="cvVVJ-DLBUuqq0M03H9_iQ" mode="Logical" visible="0">
-                        <Children>
-                          <Parameter id="yu2c_RRY_UCsAQMpDcDiYQ" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                          <Parameter id="FyNFLFUL-EW_SeqB8zA-mQ" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                          <Parameter id="DKnpi0GMGEau4Bk8MKAwCg" name="GeometricDeviation" description="Geometric standard deviation of LogNormal distribution" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1.74" />
-                        </Children>
-                      </DistributedParameter>
-                      <DistributedParameter id="ir-eVEt6kUO565A1QRGrHQ" name="Gastric emptying time" description="The time at which the (1-1/e)th part (approximately 63%) of the applied dose (fasted state) is released from the stomach into the duodenum according to a first order process. Please note that in the case that a meal is co-administered with the drug, the gastric emptying rate is described using a Weibull function. The parameters of the Weibull function and, thus, the gastric emptying time, then depend on the volume and composition of the meal" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" formula="t_Qd6-aFeEGnJIQo3Gi5dA" mode="Logical" visible="1" displayUnit="min">
-                        <Children>
-                          <Parameter id="n4ZRR-6vXkSmQuoKjtjWcQ" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" displayUnit="min" />
-                          <Parameter id="6jzklNgIpUKuwza0vFvnqw" name="Mean" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" visible="0" canBeVaried="1" value="15" displayUnit="min" />
-                          <Parameter id="BYf-8c5qdUSIXzxQyQpBPg" name="GeometricDeviation" description="Geometric standard deviation of LogNormal distribution" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1.6" />
-                        </Children>
-                      </DistributedParameter>
-                      <DistributedParameter id="o_SwgVUTe0uwTJOK_W68ww" name="Distal radius" description="Distal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="2rZ7SctDEEKttv7wH31EPg" mode="Logical" visible="1" displayUnit="cm">
-                        <Children>
-                          <Parameter id="dcXBbhJSG0mnQnnbw7GeIw" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" displayUnit="cm" />
-                          <Parameter id="80HNuU2WckujsNFA7woPMg" name="Mean" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" displayUnit="cm" />
-                        </Children>
-                      </DistributedParameter>
-                      <DistributedParameter id="4w8MBBWV4kaAR_yrobSyJg" name="Proximal radius" description="Proximal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="voSeUkZlR0G3AyLI6vmDrg" mode="Logical" visible="1" displayUnit="cm">
-                        <Children>
-                          <Parameter id="-MwaFzdPI0623wB13-2Hmw" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" displayUnit="cm" />
-                          <Parameter id="mpIQCjMOxkuH0cPaZcZ-WA" name="Mean" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" displayUnit="cm" />
-                        </Children>
-                      </DistributedParameter>
-                      <Container id="WHOsa7aQmkOE0BfmdYlJgg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                        <Children>
-                          <Parameter id="G2pA-3qCTEmKUK29MSh_Lw" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" visible="0" canBeVaried="0" />
-                          <Parameter id="XpfbLGK_HEeneW7iZJTROA" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" visible="0" canBeVaried="0" />
-                          <Parameter id="Psjob4LZ9UuquZCbN3Y1-g" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" visible="0" canBeVaried="0" />
-                          <Parameter id="lVv1uszxhEKhxxUcNRI6VA" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" visible="0" canBeVaried="0" />
-                          <Parameter id="XwtMojYMskaE4PnMWFbjXg" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" visible="0" canBeVaried="0" />
-                          <Parameter id="lNMaPZ2yDUyXSXVIlHAbEA" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" visible="0" canBeVaried="0" />
-                          <Parameter id="m70pXnyKAUqORzmcGpCsjg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="0" value="1" />
-                          <Parameter id="nOimqpHVG0SCXc1wmKNpiw" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal_GI" visible="0" canBeVaried="0" />
-                          <Parameter id="sYO9T9PuHU6HtBzCjq_N-Q" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" visible="0" canBeVaried="0" />
-                          <Parameter id="98JD1kZ5EEGXGuviw2ErpQ" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" visible="0" canBeVaried="0" />
-                          <Parameter id="06YuYdhSiEKnccKq1FSNMQ" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" visible="0" canBeVaried="0" />
-                          <Parameter id="znL6ms28zEW6-cvaf5XMVg" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" visible="0" canBeVaried="0" />
-                          <Parameter id="Utjmv9xp8UOOYeQcxJIaZg" name="Solubility" description="Solubility" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" formula="Lumen_PKSim.PARAM_IntestinalSolubility" visible="1" canBeVaried="1" displayUnit="mg/l" />
-                          <Parameter id="u5gdFgL0DESxWFQjX2Jgfg" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" visible="0" canBeVaried="0" />
-                          <Parameter id="uu3af4gqu0O3mOQfMipn1w" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" visible="0" canBeVaried="0" />
-                        </Children>
-                      </Container>
-                    </Children>
-                  </Container>
-                  <Container id="B2SJL0T_506x1Wlk3TTamQ" name="Duodenum" description="Duodenum" icon="Duodenum" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Lumen" />
-                      <Tag value="LumenSegment" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="gGwWKrsTIkWznYCVGmmpOA" name="Proximal radius" description="Proximal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R1" visible="1" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="3yuBI_gm6EWljdPuOeiVSw" name="Absorption of liquid" description="rate of liquid outflow" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Outflow_Duodenum" visible="0" canBeVaried="1" displayUnit="1/min" />
-                      <Parameter id="4eQ-TYdcNkekrDgT-BkXmA" name="Distal radius" description="Distal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R2" visible="1" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="y01Day4Sw0efEkGypTnvCw" name="FillLevelFlag" description="Fill Level Flag" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Lumen_PKSim.PARAM_FillLevelFlagFlag" visible="0" canBeVaried="1" />
-                      <Parameter id="S2C4SrBPn0iuhYU-LZWLcw" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Lumen_PKSim.PARAM_FillLevel" visible="0" canBeVaried="1" />
-                      <Parameter id="AG4k0d-FkUSeBUUpQ_iq8w" name="Geometric surface area" description="Geometric surface area of GI segment" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Area" visible="1" canBeVaried="1" displayUnit="cm²" />
-                      <Parameter id="yqzuRix_LUmq2oDuRKdGTQ" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_InverseSITT_Factor_Duodenum" visible="0" canBeVaried="1" displayUnit="1/min" />
-                      <Parameter id="_lTvVOwzvkWyF-_uhvuOHw" name="Length" description="Length" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Length" visible="1" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="jTUHOqWm7Ee8IOuTW7911Q" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Lumen_PKSim.PARAM_LiquidTransferRate_duo" visible="0" canBeVaried="0" displayUnit="l/min" />
-                      <Parameter id="x8xyyOY5FkeShn_7AnrD8A" name="Secretion of liquid" description="Rate of liquid inflow" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Inflow_Duodenum" visible="0" canBeVaried="1" displayUnit="l/min" />
-                      <Parameter id="7zhuCkHsLE20kvME1EC1vg" name="Thickness of gut wall" description="Thickness of Gut Wall" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Thickness" visible="0" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="YrSns_z06EaG_uuXNunY9A" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_LumenSegment" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Parameter id="n_ZKYUHbTUSPq_zWcYHkRw" name="Volume (gut wall)" description="Volume of the gut wall" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="MucosaVolume_Human.PARAM_VolumeGutWall_Duodenum" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Parameter id="uKjVUmYUSE-abwBJ7K5bvQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="Lk1njDAmoEGEL2FMHepw4g" name="Liquid" description="Liquid" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Liquid_StartValue" visible="0" canBeVaried="1" rHSFormula="Lumen_PKSim.LiquidRHS_duo" displayUnit="l" />
-                      <Parameter id="Yo0B1vASbkaVv4EvbD16sQ" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="6" />
-                      <Parameter id="yta_2qYxa0W65jEhwe-67g" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.30705627" displayUnit="1/cm" />
-                      <Parameter id="Tg2SODf3Y0m8grtHj_ziRQ" name="Microvilli factor" description="Microvilli factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="25" />
-                      <Parameter id="fu84Y-Nl3UWDs20KIP5GpQ" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0186500479" displayUnit="cm" />
-                      <Parameter id="Xk8SbQMaSU6lmvOzZ5AQVw" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.00925874" />
-                      <Parameter id="VR8ujqUYCES1iDo7uQomXw" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0020705161" displayUnit="cm" />
-                      <Parameter id="_8Ga8HbqQ0SdKAwBpki-oA" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.010126747" />
-                      <Parameter id="67jyBH9gA0yyaQeS6bAwVA" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.002264627" displayUnit="cm" />
-                      <Parameter id="kMi9uwT3Lk-AELAnAQKStA" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.129622362" />
-                      <Parameter id="QAiVtGW9NEuSzoyHNJx38w" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0289872252" displayUnit="cm" />
-                      <Parameter id="BQhL-0oGm0u7eFdzN8OGSA" name="Intestinal transit rate" description="Transit rate along intestinal segments" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" visible="0" canBeVaried="1" value="116" displayUnit="1/min" />
-                      <Parameter id="ehq2pkHqWEGdWJLPK6GGXg" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" visible="1" canBeVaried="1" value="0.06" />
-                      <Parameter id="XDMZzcsK0kSLBdxSmz4I0g" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0441002752" displayUnit="cm" />
-                      <DistributedParameter id="-kGNxSyldUmCKe9sGd40kA" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="0cjuJADKOEmX-K-BPkdptA" mode="Logical" visible="1">
-                        <Children>
-                          <Parameter id="yF7HgB6q6ESRocewD3SbcA" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                          <Parameter id="Ynl24TqVHkuVnCYcPwAgvw" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="292.6883" />
-                        </Children>
-                      </DistributedParameter>
-                      <Container id="X4OtaTKYt0aLljha7DKoJA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                        <Children>
-                          <Parameter id="z5loT4jK7kS9mNF5wwBkXw" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" visible="0" canBeVaried="0" rHSFormula="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_duo" value="0" displayUnit="µmol" />
-                          <Parameter id="Ul6fW9yWTUyrExdu12bf9g" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" visible="0" canBeVaried="0" />
-                          <Parameter id="x4TqUoNChUSUA1JYxZlVsg" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal_GI" visible="0" canBeVaried="0" />
-                          <Parameter id="VBHbuoLt6E6V2HCwu3Dpwg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="0" value="1" />
-                          <Parameter id="JiP5HcpEbky5tYB1OU2dJQ" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" visible="0" canBeVaried="0" />
-                          <Parameter id="CiqpLP9M0EmVdpJ1_TGtuw" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" visible="0" canBeVaried="0" />
-                          <Parameter id="cnQ4VCePi0m4vg2KEK4DNw" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" visible="0" canBeVaried="0" />
-                          <Parameter id="knwqSLWbLEylcUOhXtGNeg" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" visible="0" canBeVaried="0" />
-                          <Parameter id="ottopOBZpkqa5GFdnnRh3w" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" visible="0" canBeVaried="0" />
-                          <Parameter id="Idi23ZevGUCEl39Ey0a8Sw" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" visible="0" canBeVaried="0" />
-                          <Parameter id="qmpMhs5sY0qL1hfidyKHTg" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" visible="0" canBeVaried="0" />
-                          <Parameter id="AoQXq0J2xUmjXnZoPXM00Q" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" visible="0" canBeVaried="0" />
-                          <Parameter id="odIkMZVi3ECk3y0FJauKcw" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" visible="0" canBeVaried="0" />
-                          <Parameter id="bWip3s1zMk-K7yUmyUbVpQ" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" visible="0" canBeVaried="0" />
-                          <Parameter id="0CDm6vo590as2NGsuNq8WA" name="Solubility" description="Solubility" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" formula="Lumen_PKSim.PARAM_IntestinalSolubility" visible="1" canBeVaried="1" displayUnit="mg/l" />
-                          <Parameter id="WtBuzi-aoUC6WcBbu8W-dw" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" visible="0" canBeVaried="0" />
-                        </Children>
-                      </Container>
-                    </Children>
-                  </Container>
-                  <Container id="yZg5exSq8EiErExr7X9h7A" name="UpperJejunum" description="Upper Jejunum" icon="UpperJejunum" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Lumen" />
-                      <Tag value="LumenSegment" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="T5bYB70KeU6wJ6BdSfvoPA" name="Geometric surface area" description="Geometric surface area of GI segment" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Area" visible="1" canBeVaried="1" displayUnit="cm²" />
-                      <Parameter id="yE9DOVjA80ycpfyeDrSBgg" name="Length" description="Length" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Length" visible="1" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="9VwQSy5Zz0-mM62o-SEVwg" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Lumen_PKSim.PARAM_LiquidTransferRate_uje" visible="0" canBeVaried="0" displayUnit="l/min" />
-                      <Parameter id="NGUQKYfoBke3A4BCdxKdaw" name="Proximal radius" description="Proximal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R1" visible="1" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="xEF0UOOLVUa9ovoP9JLKqw" name="Secretion of liquid" description="Rate of liquid inflow" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Inflow_UpperJejunum" visible="0" canBeVaried="1" displayUnit="l/min" />
-                      <Parameter id="FsJhYcstWkecC_igbC0zhA" name="Thickness of gut wall" description="Thickness of Gut Wall" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Thickness" visible="0" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="hSRUpbCmTk2WKNH7n641qQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_LumenSegment" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Parameter id="AAKjzVabZkSN1JLs8JJn0g" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="5-HLIkU2JUyLQR6cfADKyw" name="Volume (gut wall)" description="Volume of the gut wall" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="MucosaVolume_Human.PARAM_VolumeGutWall_UpperJejunum" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Parameter id="9-Hg9VHGzUCZGa-1VQmwFQ" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_InverseSITT_Factor_UpperJejunum" visible="0" canBeVaried="1" displayUnit="1/min" />
-                      <Parameter id="CulAdCIiuk6UcAQjjXnpMg" name="Liquid" description="Liquid" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Liquid_StartValue" visible="0" canBeVaried="1" rHSFormula="Lumen_PKSim.LiquidRHS_uje" displayUnit="l" />
-                      <Parameter id="XIjoGGIeA0yTQv-NnQ0lLA" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Lumen_PKSim.PARAM_FillLevel" visible="0" canBeVaried="1" />
-                      <Parameter id="cUBCbBlGYEGz1v1SceWDSQ" name="Absorption of liquid" description="rate of liquid outflow" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Outflow_UpperJejunum" visible="0" canBeVaried="1" displayUnit="1/min" />
-                      <Parameter id="-eKSO-ZHb0K63FR7V1lBdw" name="Distal radius" description="Distal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R2" visible="1" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="2yzYHoivak-FA6_j4enL7w" name="FillLevelFlag" description="Fill Level Flag" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Lumen_PKSim.PARAM_FillLevelFlagFlag" visible="0" canBeVaried="1" />
-                      <Parameter id="ljA_ciLvE0GKDnQ27rjdRw" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="6.25" />
-                      <Parameter id="9QPMh6LJBkapwV5pii3plQ" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.30703115" displayUnit="1/cm" />
-                      <Parameter id="LkRFEXXL906UEHklulh2ZQ" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.299751712" />
-                      <Parameter id="LHosWQ6sv0Sq1put01kZ1A" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.00925874" />
-                      <Parameter id="LdsyKuVTfEqymx5feBEQrw" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0020705161" displayUnit="cm" />
-                      <Parameter id="LKT5f_z_hEOmVM2DUTfLFA" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0670329582" displayUnit="cm" />
-                      <Parameter id="ADCLygtpaUOmIYibff2KBw" name="Intestinal transit rate" description="Transit rate along intestinal segments" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" visible="0" canBeVaried="1" value="5.0162" displayUnit="1/min" />
-                      <Parameter id="KvOKDVe_IUic3uz-VslTWQ" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" visible="1" canBeVaried="1" value="0.064841" />
-                      <Parameter id="1QHYhh9CuECudfZz-vLEhA" name="Microvilli factor" description="Microvilli factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="25" />
-                      <Parameter id="HByGY0qtKE2--3HgMsixLg" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0589752766" displayUnit="cm" />
-                      <Parameter id="1eOenf993keqrszcmq5Brg" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.024936327" displayUnit="cm" />
-                      <Parameter id="RB3pzuhyNU6vT5d9q9Hu9Q" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.008680069" />
-                      <Parameter id="0nx5tIszSEy0whMC1J4wzw" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0019411088" displayUnit="cm" />
-                      <DistributedParameter id="gukipSlELEagtC83fAYxnQ" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="QzBJKRP1ZEuZ2TNcCm37DQ" mode="Logical" visible="1">
-                        <Children>
-                          <Parameter id="-kbg0I67wEqzZzv7hUKQog" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                          <Parameter id="srnGX3LHC0aOccBf2IqY7A" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="447.9877" />
-                        </Children>
-                      </DistributedParameter>
-                      <Container id="qMVuO4F6Ak2WHKJXpReg0Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                        <Children>
-                          <Parameter id="J8wIlVorb0mSzCBhLU-ROA" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" visible="0" canBeVaried="0" />
-                          <Parameter id="TLH55EzoaEq7zhCN88oXJg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="0" value="1" />
-                          <Parameter id="A-cDmQeniUCLF-r-_xM62Q" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" visible="0" canBeVaried="0" rHSFormula="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_uje" value="0" displayUnit="µmol" />
-                          <Parameter id="mr7C4X3K606Q92RlPcdRAw" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal_GI" visible="0" canBeVaried="0" />
-                          <Parameter id="Tf5dYik580aifuCjA85F5A" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" visible="0" canBeVaried="0" />
-                          <Parameter id="oudqKCPABkuS69S7iOaYRA" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" visible="0" canBeVaried="0" />
-                          <Parameter id="yG_mQeRGskeW-NSC9Ng3lw" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" visible="0" canBeVaried="0" />
-                          <Parameter id="PaEEHLs4g0a8o6QOfpwfjA" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" visible="0" canBeVaried="0" />
-                          <Parameter id="jm57xiyTN0yC-vb340FCBg" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" visible="0" canBeVaried="0" />
-                          <Parameter id="xiFwQxfJ5UqAPd7UHQP6AQ" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" visible="0" canBeVaried="0" />
-                          <Parameter id="hfLhsUYUu0Gp2kyiCu7j6Q" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" visible="0" canBeVaried="0" />
-                          <Parameter id="mVlwdw_Y4kSAg3-GYC77hQ" name="Solubility" description="Solubility" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" formula="Lumen_PKSim.PARAM_IntestinalSolubility" visible="1" canBeVaried="1" displayUnit="mg/l" />
-                          <Parameter id="OAbVEhIZ9Eakz11i2eB3nw" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" visible="0" canBeVaried="0" />
-                          <Parameter id="NIFwK2kF6kC7C2MZQeoVAg" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" visible="0" canBeVaried="0" />
-                          <Parameter id="PVnbn557MkmZkHuACs-M-w" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" visible="0" canBeVaried="0" />
-                          <Parameter id="U_8wgIrq0E208BS6bedZXA" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" visible="0" canBeVaried="0" />
-                        </Children>
-                      </Container>
-                    </Children>
-                  </Container>
-                  <Container id="ZDiugimqaEynDJbV3Eje2g" name="LowerJejunum" description="Lower Jejunum" icon="LowerJejunum" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Lumen" />
-                      <Tag value="LumenSegment" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="OFoa5aD_40228XEULX-hTQ" name="Volume (gut wall)" description="Volume of the gut wall" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="MucosaVolume_Human.PARAM_VolumeGutWall_LowerJejunum" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Parameter id="nqtyRjS-2U2xngLkGH-WUQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="dxcFo7SeW0WTGEoV_yiI6Q" name="Thickness of gut wall" description="Thickness of Gut Wall" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Thickness" visible="0" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="jQutTThkxk-vTEkXJPiIkA" name="Absorption of liquid" description="rate of liquid outflow" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Outflow_LowerJejunum" visible="0" canBeVaried="1" displayUnit="1/min" />
-                      <Parameter id="PfCHDqpq9EC3EHn2FPKTLQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_LumenSegment" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Parameter id="RLs7CxfO2UylY3GofshWKA" name="Distal radius" description="Distal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R2" visible="1" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="wQqWV_GgE06h9aBKfIQSmQ" name="FillLevelFlag" description="Fill Level Flag" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Lumen_PKSim.PARAM_FillLevelFlagFlag" visible="0" canBeVaried="1" />
-                      <Parameter id="125YCFyic06B9q7Jtqhqug" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Lumen_PKSim.PARAM_FillLevel" visible="0" canBeVaried="1" />
-                      <Parameter id="sPjzaT4tikGHHjxO2jWOWg" name="Geometric surface area" description="Geometric surface area of GI segment" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Area" visible="1" canBeVaried="1" displayUnit="cm²" />
-                      <Parameter id="2H9_eQj6vkSxGOk7Jde3Zg" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_InverseSITT_Factor_LowerJejunum" visible="0" canBeVaried="1" displayUnit="1/min" />
-                      <Parameter id="OLvGIXjDdk6brHPACp6UqA" name="Length" description="Length" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Length" visible="1" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="RyxV_ab0rE-XObwq2D9TjQ" name="Liquid" description="Liquid" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Liquid_StartValue" visible="0" canBeVaried="1" rHSFormula="Lumen_PKSim.LiquidRHS_lje" displayUnit="l" />
-                      <Parameter id="1zkjIeF5vkCPGTS3NzPodA" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Lumen_PKSim.PARAM_LiquidTransferRate_lje" visible="0" canBeVaried="0" displayUnit="l/min" />
-                      <Parameter id="rSqi80OIH0-LbFWm2OF2Ow" name="Proximal radius" description="Proximal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R1" visible="1" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="9fzsgzickEutFruWnJM64w" name="Secretion of liquid" description="Rate of liquid inflow" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Inflow_LowerJejunum" visible="0" canBeVaried="1" displayUnit="l/min" />
-                      <Parameter id="PMcp7mVDUkWegDxI_5oGtw" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0019411088" displayUnit="cm" />
-                      <Parameter id="v07JKkTuU0Cv8ha_92Ff1w" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.30703115" displayUnit="1/cm" />
-                      <Parameter id="UTdwhJPP20K8vRDzW6YThA" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0465856499" displayUnit="cm" />
-                      <Parameter id="IkstwV7dmEiL2ZucnQEzNg" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.008101398" />
-                      <Parameter id="oeNAb3O-qUGd-mskymAisg" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0018117016" displayUnit="cm" />
-                      <Parameter id="5HlXshn3cEmW8KUCUxvrUg" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.008680069" />
-                      <Parameter id="sC8nRFcwSUqbJpijRy0whA" name="Microvilli factor" description="Microvilli factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="25" />
-                      <Parameter id="YYPOm7JsI0OLkKLNpF-66A" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.299751712" />
-                      <Parameter id="ROO6iKx-qEeNHYeyWb71Rg" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0670329582" displayUnit="cm" />
-                      <Parameter id="c-34kapTgEONZQIUATATgw" name="Intestinal transit rate" description="Transit rate along intestinal segments" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" visible="0" canBeVaried="1" value="5.0162" displayUnit="1/min" />
-                      <Parameter id="priInc0sMUGJjAq-NUyfQQ" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" visible="1" canBeVaried="1" value="0.064841" />
-                      <Parameter id="QLAdUtpuVEafIWVrnX08jA" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0196976609" displayUnit="cm" />
-                      <Parameter id="pwDmJwg9HE6PvzyUH2RD8w" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="6.9167" />
-                      <DistributedParameter id="HmpKiYoBhkCijXe-sgUDSA" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="JD5uPYgG2UiM4klfDuppCQ" mode="Logical" visible="1">
-                        <Children>
-                          <Parameter id="PHYEL-hu8ESo6ilxErKYpA" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                          <Parameter id="jTvqTcUomUiH0tFrdoLEWg" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="372.9358" />
-                        </Children>
-                      </DistributedParameter>
-                      <Container id="yvo9YiRhT06MKd7qa37jDg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                        <Children>
-                          <Parameter id="flRLq76gO0awtUvMUXYjBw" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" visible="0" canBeVaried="0" />
-                          <Parameter id="oYkbY1Nkc0CHym-47rwDXQ" name="Solubility" description="Solubility" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" formula="Lumen_PKSim.PARAM_IntestinalSolubility" visible="1" canBeVaried="1" displayUnit="mg/l" />
-                          <Parameter id="p-NiEKI7BU-jLZXS7WNbFw" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" visible="0" canBeVaried="0" />
-                          <Parameter id="6Y5rwJ_hRkq7XHTHs_zM1g" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" visible="0" canBeVaried="0" />
-                          <Parameter id="sCFOUwtO5kCbHskLK4IyWA" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" visible="0" canBeVaried="0" rHSFormula="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_lje" value="0" displayUnit="µmol" />
-                          <Parameter id="3-j48bQykkOeqwwVfano4A" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" visible="0" canBeVaried="0" />
-                          <Parameter id="fTAfL4kZs02idapnirSZgw" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal_GI" visible="0" canBeVaried="0" />
-                          <Parameter id="M8WCc5WLA06VrObr_s4N8A" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" visible="0" canBeVaried="0" />
-                          <Parameter id="34JXEtEGU0KAOZYmw4oXAQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="0" value="1" />
-                          <Parameter id="5YuYZtVHD0qguLi4LhZDkQ" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" visible="0" canBeVaried="0" />
-                          <Parameter id="xHu95_X8Gke4RKtGjNQeHA" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" visible="0" canBeVaried="0" />
-                          <Parameter id="3eVzLIlkrEyghjwVfSL7xQ" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" visible="0" canBeVaried="0" />
-                          <Parameter id="B3Fd7Jz1F02E0FeyJf9uSw" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" visible="0" canBeVaried="0" />
-                          <Parameter id="s87_OQzd60udIyJhMyj__Q" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" visible="0" canBeVaried="0" />
-                          <Parameter id="dvnySQP3RUWgyO6mZ3gBLw" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" visible="0" canBeVaried="0" />
-                          <Parameter id="Lgz85w_PY0SqhjPtFG9ZYA" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" visible="0" canBeVaried="0" />
-                        </Children>
-                      </Container>
-                    </Children>
-                  </Container>
-                  <Container id="GllsaRsHZUOo1T5JiPknaA" name="UpperIleum" description="Upper Ileum" icon="UpperIleum" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Lumen" />
-                      <Tag value="LumenSegment" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="a2GkNcncI0uClPkcp9wi9g" name="Secretion of liquid" description="Rate of liquid inflow" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Inflow_UpperIleum" visible="0" canBeVaried="1" displayUnit="l/min" />
-                      <Parameter id="6dvYzwIzg0-vOCHJh5awLg" name="Absorption of liquid" description="rate of liquid outflow" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Outflow_UpperIleum" visible="0" canBeVaried="1" displayUnit="1/min" />
-                      <Parameter id="r5uvYm5FD0qKe0qLIZhFMQ" name="Distal radius" description="Distal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R2" visible="1" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="FbD00tButke226lfbISojQ" name="FillLevelFlag" description="Fill Level Flag" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Lumen_PKSim.PARAM_FillLevelFlagFlag" visible="0" canBeVaried="1" />
-                      <Parameter id="kqr094hHBEWBRl_w2neHrw" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Lumen_PKSim.PARAM_FillLevel" visible="0" canBeVaried="1" />
-                      <Parameter id="Ot3UAXZl_kCi7LQm7m2RkA" name="Geometric surface area" description="Geometric surface area of GI segment" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Area" visible="1" canBeVaried="1" displayUnit="cm²" />
-                      <Parameter id="JwFtlDNxskS2wzEYuyzW_w" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_InverseSITT_Factor_UpperIleum" visible="0" canBeVaried="1" displayUnit="1/min" />
-                      <Parameter id="xbTz_XvhGkOyZL1W581AFg" name="Length" description="Length" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Length" visible="1" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="nURZpPRMA0688szNr4JV9A" name="Liquid" description="Liquid" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Liquid_StartValue" visible="0" canBeVaried="1" rHSFormula="Lumen_PKSim.LiquidRHS_uil" displayUnit="l" />
-                      <Parameter id="1OFo5J_zQ0-lure2SsLN0g" name="Proximal radius" description="Proximal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R1" visible="1" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="uxbgek4ZWkag3I95HLGiAg" name="Thickness of gut wall" description="Thickness of Gut Wall" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Thickness" visible="0" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="T8u6Msrao0-fxn173ixELw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_LumenSegment" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Parameter id="Nz5PfRQOfUyge-Sq05wvbA" name="Volume (gut wall)" description="Volume of the gut wall" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="MucosaVolume_Human.PARAM_VolumeGutWall_UpperIleum" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Parameter id="DBa4pECdvEeFPImPwOtoFg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="heYfR5Ib0ECmzvhVgLLcKg" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Lumen_PKSim.PARAM_LiquidTransferRate_uil" visible="0" canBeVaried="0" displayUnit="l/min" />
-                      <Parameter id="_3x24lQ0pEiZfGLf-yU2Xw" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.30703115" displayUnit="1/cm" />
-                      <Parameter id="O8axTuoRbEq65qdemtuykA" name="Intestinal transit rate" description="Transit rate along intestinal segments" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" visible="0" canBeVaried="1" value="3.3745" displayUnit="1/min" />
-                      <Parameter id="ufCgdSXvY0aY-QgEPEO4rw" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.061552122" displayUnit="cm" />
-                      <Parameter id="KRKEhGIFEUSjBc0REuMEpQ" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0260258863" displayUnit="cm" />
-                      <Parameter id="KRYW-sdNaUO_LLcix7SEdA" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.006944055" />
-                      <Parameter id="01k7e2dJUUC9VvqvZ4tQDw" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0015528871" displayUnit="cm" />
-                      <Parameter id="brKX7CwscUONLtgzpTWdPA" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.008101398" />
-                      <Parameter id="OUqOZdMzKUaDFWJKngTg1A" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0018117016" displayUnit="cm" />
-                      <Parameter id="MXZ1RzeZ6kiDrZY6GRpz1w" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" visible="1" canBeVaried="1" value="0.064841" />
-                      <Parameter id="9izDkSXXOk-JhlBoS4U4gA" name="Microvilli factor" description="Microvilli factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="25" />
-                      <Parameter id="aMg0nnPITESuOKXjyjxOeA" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.445576869" />
-                      <Parameter id="sqkRxSSFIUSC3ucyjY3vOA" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0996435866" displayUnit="cm" />
-                      <Parameter id="UrIIX7xNzEC7qwos_PLdbA" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.2083" />
-                      <DistributedParameter id="yziPD3dZdUG9zp_eWgrkjQ" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="OavS00jhT0Kl8BGNMnfCKw" mode="Logical" visible="1">
-                        <Children>
-                          <Parameter id="QgoNlEIinUWmxRijRR7ESA" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                          <Parameter id="wlWpB2MUJEKYAfdwnwWFPw" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="260.7527" />
-                        </Children>
-                      </DistributedParameter>
-                      <Container id="3MOdew-CBEaM4lPiqh9MxA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                        <Children>
-                          <Parameter id="FcFUy2uQRUKkI_zMY33hHA" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" visible="0" canBeVaried="0" />
-                          <Parameter id="ppEcAqGLZESFruKGPf4nHA" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" visible="0" canBeVaried="0" />
-                          <Parameter id="2A9pheTZr0ups1Rg8g3m_w" name="Solubility" description="Solubility" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" formula="Lumen_PKSim.PARAM_IntestinalSolubility" visible="1" canBeVaried="1" displayUnit="mg/l" />
-                          <Parameter id="0sp06veY80GDVIydsibJ8Q" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" visible="0" canBeVaried="0" />
-                          <Parameter id="V6gypJn6EkaIJOVR51iAJA" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" visible="0" canBeVaried="0" />
-                          <Parameter id="jd19NRLHOUy0EsXXg1HcTw" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" visible="0" canBeVaried="0" />
-                          <Parameter id="tcC0_J8fNkqQfjn3yiNteg" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" visible="0" canBeVaried="0" />
-                          <Parameter id="E_bZ1XAfPE-Igzqydo5jPg" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" visible="0" canBeVaried="0" />
-                          <Parameter id="yr7FNK13KkuOwPo3CMN83A" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" visible="0" canBeVaried="0" />
-                          <Parameter id="tSVLjgG-bEO4T90XDJ5iYQ" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" visible="0" canBeVaried="0" />
-                          <Parameter id="H9D3W4AWNUOk4M00wzclPQ" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" visible="0" canBeVaried="0" />
-                          <Parameter id="54Sd20Ae1kKX_D5MFkJVGA" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" visible="0" canBeVaried="0" />
-                          <Parameter id="TDCVJ28zkUSyJd7Ef9Qjug" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="0" value="1" />
-                          <Parameter id="5A3YGE5rMkC60M6Qwkr9nw" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" visible="0" canBeVaried="0" rHSFormula="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_uil" value="0" displayUnit="µmol" />
-                          <Parameter id="4LtbQNBuREa2BvN95bzbzA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal_GI" visible="0" canBeVaried="0" />
-                          <Parameter id="bRDodopx5U29pZr52bTXoA" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" visible="0" canBeVaried="0" />
-                        </Children>
-                      </Container>
-                    </Children>
-                  </Container>
-                  <Container id="vCPS2yMfPkKIhDcs0uJgFQ" name="LowerIleum" description="Lower Ileum" icon="LowerIleum" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Lumen" />
-                      <Tag value="LumenSegment" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="kh_SpEgOPU2lFUL9oPynIQ" name="Geometric surface area" description="Geometric surface area of GI segment" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Area" visible="1" canBeVaried="1" displayUnit="cm²" />
-                      <Parameter id="d9MFJhOsg0Ce4C7vNlXjcA" name="Absorption of liquid" description="rate of liquid outflow" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Outflow_LowerIleum" visible="0" canBeVaried="1" displayUnit="1/min" />
-                      <Parameter id="IdgoOrOvNEKdJm43M34SlQ" name="Distal radius" description="Distal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R2" visible="1" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="-CtgLW47XkafAda0Ybg43Q" name="FillLevelFlag" description="Fill Level Flag" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Lumen_PKSim.PARAM_FillLevelFlagFlag" visible="0" canBeVaried="1" />
-                      <Parameter id="o7XPEnffckWArz2FHcR1sQ" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_InverseSITT_Factor_LowerIleum" visible="0" canBeVaried="1" displayUnit="1/min" />
-                      <Parameter id="Wt8EXGk7Ik2zGdDjA7BORw" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Lumen_PKSim.PARAM_FillLevel" visible="0" canBeVaried="1" />
-                      <Parameter id="Sb3ST7J1TE2Cu5uwwwHNDQ" name="Length" description="Length" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Length" visible="1" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="t8S7j8o2T0ayEf0H0ctezg" name="Liquid" description="Liquid" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Liquid_StartValue" visible="0" canBeVaried="1" rHSFormula="Lumen_PKSim.LiquidRHS_lil" displayUnit="l" />
-                      <Parameter id="WCIm0RT9ck6eLPM_lxlkZA" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Lumen_PKSim.PARAM_LiquidTransferRate_lil" visible="0" canBeVaried="0" displayUnit="l/min" />
-                      <Parameter id="q-4057jaAkG3crye5Fg6Ig" name="Proximal radius" description="Proximal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R1" visible="1" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="n_coeeB78EuaDFw2a9foKw" name="Secretion of liquid" description="Rate of liquid inflow" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Inflow_LowerIleum" visible="0" canBeVaried="1" displayUnit="l/min" />
-                      <Parameter id="q32Tk2eiGk2oKlgyD3h5zA" name="Thickness of gut wall" description="Thickness of Gut Wall" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Thickness" visible="0" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="gwrqDsAN2UGmJg9L2RpqGg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_LumenSegment" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Parameter id="vWH2p75TaUm4Kn2YGK39BQ" name="Volume (gut wall)" description="Volume of the gut wall" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="MucosaVolume_Human.PARAM_VolumeGutWall_LowerIleum" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Parameter id="1KofRpDdX0iSaXCFGTw98A" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="7391ZxxWsEKf-lwfSasvcA" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" visible="1" canBeVaried="1" value="0.064841" />
-                      <Parameter id="_vdSUClFakSHPvEtvgMeew" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0015528871" displayUnit="cm" />
-                      <Parameter id="QS0Mc7es3EO7PHc-AoKOtw" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.30705627" displayUnit="1/cm" />
-                      <Parameter id="k7-DVmpu30ydy0S0RRJVVw" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0350288649" displayUnit="cm" />
-                      <Parameter id="wzUr9VsB1Um8uHq-Tl3eNQ" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0148137399" displayUnit="cm" />
-                      <Parameter id="ZVOpwcAx30C4MRWFc-UtLA" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.005786713" />
-                      <Parameter id="3hhntomVcUyFkXhaAWTnNQ" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0012940725" displayUnit="cm" />
-                      <Parameter id="VXwrVdQwMkKbUWxMGGsECQ" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.006944055" />
-                      <Parameter id="9aYz3sdKq0etEhILsx9fAQ" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.4583" />
-                      <Parameter id="GhOhCtx4aEebDd4x1Q4EmQ" name="Microvilli factor" description="Microvilli factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="25" />
-                      <Parameter id="Cxhqh5BBJEGFBUWeitJ2Ow" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.445576869" />
-                      <Parameter id="ucucMhx4fUKcOkI_kczYuw" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0996435866" displayUnit="cm" />
-                      <Parameter id="oQMtdadgd06eMuiZUJJ5Xw" name="Intestinal transit rate" description="Transit rate along intestinal segments" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" visible="0" canBeVaried="1" value="3.3745" displayUnit="1/min" />
-                      <DistributedParameter id="Dd2maW0N60-iE8yAtMML8A" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="u8GosNQmv0iy2QPr7LMEOw" mode="Logical" visible="1">
-                        <Children>
-                          <Parameter id="0vSMHrWhm0uQMdnyW0k9vA" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                          <Parameter id="Pa2MUluggEan_a-iiC05VQ" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="146.565" />
-                        </Children>
-                      </DistributedParameter>
-                      <Container id="9u38ciR_QU-2yfc7VXCSgA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                        <Children>
-                          <Parameter id="P__C_efOLk6JXPNp_UxjVw" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" visible="0" canBeVaried="0" />
-                          <Parameter id="6zocQFpUyEOCrJOagrza_Q" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal_GI" visible="0" canBeVaried="0" />
-                          <Parameter id="uI2y56-0n0SiJnJY1wgwXQ" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" visible="0" canBeVaried="0" rHSFormula="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_lil" value="0" displayUnit="µmol" />
-                          <Parameter id="PzuuZIcjGUqvPcdjQ7Bb_w" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="0" value="1" />
-                          <Parameter id="WWJsy4ZwYEqjPyXe2sFhCQ" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" visible="0" canBeVaried="0" />
-                          <Parameter id="ZDHedyprv0ucSrG2mX9a1A" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" visible="0" canBeVaried="0" />
-                          <Parameter id="cpOkTGvNIEij8OPooe9kjQ" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" visible="0" canBeVaried="0" />
-                          <Parameter id="mNEtMK2NRkqW8He-Tzc9jw" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" visible="0" canBeVaried="0" />
-                          <Parameter id="li1F0KI0rkq0iyC3Oxls2Q" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" visible="0" canBeVaried="0" />
-                          <Parameter id="zqjXuyo6r0SXIUpHHgZo1g" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" visible="0" canBeVaried="0" />
-                          <Parameter id="v3oqt0qPrUKEmWG8ETR6ew" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" visible="0" canBeVaried="0" />
-                          <Parameter id="gJuuRtVED0SsYNBetGbhBA" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" visible="0" canBeVaried="0" />
-                          <Parameter id="7m0VNFOSdk6JE30EdGvSAg" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" visible="0" canBeVaried="0" />
-                          <Parameter id="QJGzZh_1m0SO94brMFzDXw" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" visible="0" canBeVaried="0" />
-                          <Parameter id="DpnSq5oveEKUMETwLblZsA" name="Solubility" description="Solubility" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" formula="Lumen_PKSim.PARAM_IntestinalSolubility" visible="1" canBeVaried="1" displayUnit="mg/l" />
-                          <Parameter id="zhWaif-DGUenQm8w-BaupA" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" visible="0" canBeVaried="0" />
-                        </Children>
-                      </Container>
-                    </Children>
-                  </Container>
-                  <Container id="sk41NH_8KEi_nNbtDlGvFA" name="Caecum" description="Cecum" icon="Caecum" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Lumen" />
-                      <Tag value="LumenSegment" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="gToiH_HN80SqYdOEPEREhA" name="Volume (gut wall)" description="Volume of the gut wall" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="MucosaVolume_Human.PARAM_VolumeGutWall_Caecum" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Parameter id="Nwi502Vet0G9rjE2Z8kOpQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="E0LVcdWbhk-SLj_buVXJ4A" name="Distal radius" description="Distal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R2" visible="1" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="a6kaYGjzBkq6LhcP8jhvFg" name="Absorption of liquid" description="rate of liquid outflow" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Outflow_Caecum" visible="0" canBeVaried="1" displayUnit="1/min" />
-                      <Parameter id="oYRvfJFekkCTA524j2Wmdg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_LumenSegment" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Parameter id="PRK1FE0Ez0OkWkklE7JIMA" name="FillLevelFlag" description="Fill Level Flag" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Lumen_PKSim.PARAM_FillLevelFlagFlag" visible="0" canBeVaried="1" />
-                      <Parameter id="w2-duxeNX0-ZLM9E3_V2EQ" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Lumen_PKSim.PARAM_FillLevel" visible="0" canBeVaried="1" />
-                      <Parameter id="Pe1yKTL8hkCl2-nKeZJWgg" name="Geometric surface area" description="Geometric surface area of GI segment" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Area" visible="1" canBeVaried="1" displayUnit="cm²" />
-                      <Parameter id="Zr0sYCtn00ixQom3uszg0Q" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_InverseLITT_Factor_Caecum" visible="0" canBeVaried="1" displayUnit="1/min" />
-                      <Parameter id="L-iTq8ijD0KsZusg4tJm2g" name="Length" description="Length" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Length" visible="1" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="6oVrtAPPFUyejLLiKWfAsQ" name="Liquid" description="Liquid" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Liquid_StartValue" visible="0" canBeVaried="1" rHSFormula="Lumen_PKSim.LiquidRHS_cae" displayUnit="l" />
-                      <Parameter id="zuXQZtFQeE6UnViJ1zBxFg" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Lumen_PKSim.PARAM_LiquidTransferRate_cae" visible="0" canBeVaried="0" displayUnit="l/min" />
-                      <Parameter id="gB88liaA00asPJ6srGUy1A" name="Proximal radius" description="Proximal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R1" visible="1" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="amqfKmZaBUmTvZS0d48Gpg" name="Secretion of liquid" description="Rate of liquid inflow" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Inflow_Caecum" visible="0" canBeVaried="1" displayUnit="l/min" />
-                      <Parameter id="9ksbuIGfNEG9VLvs6f5BGg" name="Thickness of gut wall" description="Thickness of Gut Wall" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Thickness" visible="0" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="oNCBCC1H70OFgwfzoj5ymA" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0060009" />
-                      <Parameter id="a2eWsugqn0GJCrM7APrhcw" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0446435379" displayUnit="cm" />
-                      <Parameter id="MQYrv1Hsg06YtGXxJF-I7g" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.00877" displayUnit="cm" />
-                      <Parameter id="62dNon1_BE2rTW_APfXJ_Q" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.015672726" />
-                      <Parameter id="AsOiAnu6zE6ej3QE6QI0uQ" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.067256381" displayUnit="cm" />
-                      <Parameter id="_GTgvfKtwUWsFXt9qun_zw" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.015672726" />
-                      <Parameter id="b-o2UQBYlE2zyj8wEGt0JA" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.067256381" displayUnit="cm" />
-                      <Parameter id="7PY0kjH8ZkKCTVpa6Bje3g" name="Microvilli factor" description="Microvilli factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                      <Parameter id="ax74o0HE1U6eK4v5qHuGyg" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.026864843" />
-                      <Parameter id="4P33PXH950iyxBhPfoZipg" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.1152851235" displayUnit="cm" />
-                      <Parameter id="zg3g5pUupU2Mp8Ay3no_zQ" name="Intestinal transit rate" description="Transit rate along intestinal segments" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" visible="0" canBeVaried="1" value="18.3333" displayUnit="1/min" />
-                      <Parameter id="A3e2pt_IcUyEQ3Tj009rsg" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0897885" displayUnit="1/cm" />
-                      <Parameter id="3amM8GpOs0qiotq02w1snA" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="5.7" />
-                      <DistributedParameter id="FgQ-FcIpkU67WGS3N4QX2A" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="oHit47I8Hk6_2opTctJUCA" mode="Logical" visible="1">
-                        <Children>
-                          <Parameter id="TiVG1mvBu06TtlRGZEhjHQ" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                          <Parameter id="z7rb74fSQU-BuaTUIH5-PQ" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1.8" />
-                        </Children>
-                      </DistributedParameter>
-                      <Container id="roHdhepN4U2CuJZxmpRwCQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                        <Children>
-                          <Parameter id="lSEEE17KgUWraEuPJrsW3w" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" visible="0" canBeVaried="0" />
-                          <Parameter id="BE1MKZ_dhEen2DL_7LL5Jg" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal_GI" visible="0" canBeVaried="0" />
-                          <Parameter id="7Q-E9DA2YkG-AAffcg_HqA" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" visible="0" canBeVaried="0" rHSFormula="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_cae" value="0" displayUnit="µmol" />
-                          <Parameter id="j27_hJy1KUuTKAJzADxV_w" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="0" value="1" />
-                          <Parameter id="U2M6KYRtTUGt8spHAyx-SQ" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" visible="0" canBeVaried="0" />
-                          <Parameter id="09DiKApI_kOV2zUicF_XYw" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" visible="0" canBeVaried="0" />
-                          <Parameter id="APlmwYRaeUi8ewW2Ba1D7g" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" visible="0" canBeVaried="0" />
-                          <Parameter id="bTMzOxCfvUyVdIJD4mSh2Q" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" visible="0" canBeVaried="0" />
-                          <Parameter id="y386tFiLzk2HXdmILwKCVw" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" visible="0" canBeVaried="0" />
-                          <Parameter id="miieZ3YFzEW0RMLpLxW6uQ" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" visible="0" canBeVaried="0" />
-                          <Parameter id="Twt-BhI_mkKUuZGs7O9Q4A" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" visible="0" canBeVaried="0" />
-                          <Parameter id="S_WQp0Y9KUCoWi2LOijxww" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" visible="0" canBeVaried="0" />
-                          <Parameter id="wt6RG0zNDkO2pHtvtgsfYw" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" visible="0" canBeVaried="0" />
-                          <Parameter id="FkH71QboOUeOcyhgps1SXg" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" visible="0" canBeVaried="0" />
-                          <Parameter id="92NjfYHQQEKEweDBZqRJmg" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" visible="0" canBeVaried="0" />
-                          <Parameter id="1Szu0BZJQEmY6oRdv1W9CQ" name="Solubility" description="Solubility" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" formula="Lumen_PKSim.PARAM_IntestinalSolubility" visible="1" canBeVaried="1" displayUnit="mg/l" />
-                        </Children>
-                      </Container>
-                    </Children>
-                  </Container>
-                  <Container id="xYyLHo4Vhk6D6RJrPpFicA" name="ColonAscendens" description="Colon Ascendens" icon="ColonAscendens" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Lumen" />
-                      <Tag value="LumenSegment" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="KNKeBc2R60-3GQ0n7BwVyw" name="Thickness of gut wall" description="Thickness of Gut Wall" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Thickness" visible="0" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="EuzCfKDd7EmCfDrChQ-JVQ" name="Absorption of liquid" description="rate of liquid outflow" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Outflow_ColonAscendens" visible="0" canBeVaried="1" displayUnit="1/min" />
-                      <Parameter id="mWdp8dv1akibZkNQmj5A9Q" name="Distal radius" description="Distal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R2" visible="1" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="kFsIDEior0OWmlrXCLESyw" name="FillLevelFlag" description="Fill Level Flag" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Lumen_PKSim.PARAM_FillLevelFlagFlag" visible="0" canBeVaried="1" />
-                      <Parameter id="E6LAQzyZVE2N4NQeuDqVvw" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Lumen_PKSim.PARAM_FillLevel" visible="0" canBeVaried="1" />
-                      <Parameter id="cJ8MDXS7002EmoC7UK-psg" name="Geometric surface area" description="Geometric surface area of GI segment" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Area" visible="1" canBeVaried="1" displayUnit="cm²" />
-                      <Parameter id="iJIVliOXnUaOszHEp8KzXA" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_InverseLITT_Factor_ColonAscendens" visible="0" canBeVaried="1" displayUnit="1/min" />
-                      <Parameter id="adzP2OfBuEuwEikUlGS8WQ" name="Length" description="Length" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Length" visible="1" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="DXFEeuQ_90iRWGDwDblaqg" name="Liquid" description="Liquid" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Liquid_StartValue" visible="0" canBeVaried="1" rHSFormula="Lumen_PKSim.LiquidRHS_colasc" displayUnit="l" />
-                      <Parameter id="5mpe7C5hA0edNRzvY-IdTw" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Lumen_PKSim.PARAM_LiquidTransferRate_colasc" visible="0" canBeVaried="0" displayUnit="l/min" />
-                      <Parameter id="I58SkXfflkq41JS7eLtY2w" name="Secretion of liquid" description="Rate of liquid inflow" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Inflow_ColonAscendens" visible="0" canBeVaried="1" displayUnit="l/min" />
-                      <Parameter id="yQgFTXWlO0C7lJ6_LOjFag" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_LumenSegment" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Parameter id="LF_e6DoE1UmI0XvfjGzlWQ" name="Volume (gut wall)" description="Volume of the gut wall" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="MucosaVolume_Human.PARAM_VolumeGutWall_ColonAscendens" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Parameter id="0ATLLfFN6kiChcklZhBJpA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="EqhXpioMhUeoWaOSHyUTDw" name="Proximal radius" description="Proximal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R1" visible="1" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="mEK3YoOGnEi3MEyWPm33iQ" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.09106073" displayUnit="1/cm" />
-                      <Parameter id="1OlkgnYAWUuUmCMpXpavUg" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0280138174" displayUnit="cm" />
-                      <Parameter id="RXWnF7meVEW6iaV2KGgzMw" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.00554" displayUnit="cm" />
-                      <Parameter id="uPg1vIzVzESoLyaV23ytnw" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.067256381" displayUnit="cm" />
-                      <Parameter id="-Ig_K2Dym021s9Ws__Q_8w" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.015672726" />
-                      <Parameter id="Uh182ZUWyEujmSKJziQGHQ" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.067256381" displayUnit="cm" />
-                      <Parameter id="S5k4A9rRz0yTiEzJjxWq5Q" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="5.6" />
-                      <Parameter id="QX-OxQgp6kSuti7nPeQQQQ" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.015672726" />
-                      <Parameter id="Ok3w4ly8QUWworTqXjz12g" name="Microvilli factor" description="Microvilli factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                      <Parameter id="vNdK9-fdM0S0Su5yO6bNmQ" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.075727844" />
-                      <Parameter id="bGNo8o9jdkaXHKVgPuf9Cg" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.3117189273" displayUnit="cm" />
-                      <Parameter id="oL4NwHi-DUKi3DZgutwigA" name="Intestinal transit rate" description="Transit rate along intestinal segments" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" visible="0" canBeVaried="1" value="10" displayUnit="1/min" />
-                      <Parameter id="JOKDq9srWEKgVUNRaKg2fA" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0060009" />
-                      <DistributedParameter id="z8ms_CzKeEapBplzPdB-LQ" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="1N7zSPApMkGHQv7WuT_Mcw" mode="Logical" visible="1">
-                        <Children>
-                          <Parameter id="XWdg-UrHpE2EZdLSjvPkFA" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                          <Parameter id="AN7nxhk6dUCpdp7mxWHpqw" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="2.5" />
-                        </Children>
-                      </DistributedParameter>
-                      <Container id="syKwn295jEqfzqiUgKRW7A" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                        <Children>
-                          <Parameter id="-QBcotx1BE-iSr_uI4X0PQ" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal_GI" visible="0" canBeVaried="0" />
-                          <Parameter id="85U3b0kqbUOp5YcEtvpUQw" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" visible="0" canBeVaried="0" />
-                          <Parameter id="R7sLKCsgIEGIeI6KjimRsA" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" visible="0" canBeVaried="0" rHSFormula="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_colasc" value="0" displayUnit="µmol" />
-                          <Parameter id="4CRan7JTN0SPpwaNQz-C8g" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="0" value="1" />
-                          <Parameter id="wrCgjZHXWUyNNXmbRp7kTQ" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" visible="0" canBeVaried="0" />
-                          <Parameter id="kva22Q81zEKiH_H7Uq0ZBw" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" visible="0" canBeVaried="0" />
-                          <Parameter id="m2cTJUZREU2a_zxQYnA13Q" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" visible="0" canBeVaried="0" />
-                          <Parameter id="N7ApCmDjAEKmB98rXQ71og" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" visible="0" canBeVaried="0" />
-                          <Parameter id="zXYc7rSNbUmybovfSCO8Bg" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" visible="0" canBeVaried="0" />
-                          <Parameter id="hegX42EcH0G6JPSrArlkgw" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" visible="0" canBeVaried="0" />
-                          <Parameter id="SPdg8y6xrkqrpLW2Zp-pOg" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" visible="0" canBeVaried="0" />
-                          <Parameter id="4z3VJoqJYUqDGBgI469L8g" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" visible="0" canBeVaried="0" />
-                          <Parameter id="xztWFjE_SUSLoNHwrEOzxg" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" visible="0" canBeVaried="0" />
-                          <Parameter id="_WesX-q9nkS8Ix-M-XSZ7A" name="Solubility" description="Solubility" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" formula="Lumen_PKSim.PARAM_IntestinalSolubility" visible="1" canBeVaried="1" displayUnit="mg/l" />
-                          <Parameter id="JtO4ClpRG0eAFxnwhbaAkA" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" visible="0" canBeVaried="0" />
-                          <Parameter id="awrM0bqmkEq05Pv0_eBjKQ" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" visible="0" canBeVaried="0" />
-                        </Children>
-                      </Container>
-                    </Children>
-                  </Container>
-                  <Container id="EhWe8Xqa6EKqp-YjJgQUiw" name="ColonTransversum" description="Colon Transversum" icon="ColonTransversum" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Lumen" />
-                      <Tag value="LumenSegment" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="H1V9ErgHk0CxUCdYvDh7tg" name="Length" description="Length" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Length" visible="1" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="J0BMS9a5jEumB-XCW-PiJA" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Lumen_PKSim.PARAM_LiquidTransferRate_coltrans" visible="0" canBeVaried="0" displayUnit="l/min" />
-                      <Parameter id="6fBptez7tkKzl8pS_1xBeA" name="Proximal radius" description="Proximal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R1" visible="1" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="msO8PKmq9EiI4hfZMlnybA" name="Secretion of liquid" description="Rate of liquid inflow" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Inflow_ColonTransversum" visible="0" canBeVaried="1" displayUnit="l/min" />
-                      <Parameter id="0wwplg8omUOxZjzbqKoPKw" name="Thickness of gut wall" description="Thickness of Gut Wall" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Thickness" visible="0" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="EVfUyOpPEkGVALpa7Uw5JA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_LumenSegment" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Parameter id="_KW7ZbeYGkmMic8h-aaZLQ" name="Volume (gut wall)" description="Volume of the gut wall" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="MucosaVolume_Human.PARAM_VolumeGutWall_ColonTransversum" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Parameter id="QxXdycspKky30i-ze8vqjg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="35fXNzOhWkS6e7uE4Ltj6w" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_InverseLITT_Factor_ColonTransversum" visible="0" canBeVaried="1" displayUnit="1/min" />
-                      <Parameter id="pIWI5VJqdEuZKOM68npr-g" name="Liquid" description="Liquid" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Liquid_StartValue" visible="0" canBeVaried="1" rHSFormula="Lumen_PKSim.LiquidRHS_coltrans" displayUnit="l" />
-                      <Parameter id="S82jSlVXO0i0ThcP2Vqixg" name="Absorption of liquid" description="rate of liquid outflow" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Outflow_ColonTransversum" visible="0" canBeVaried="1" displayUnit="1/min" />
-                      <Parameter id="3KjT-_RqBEuLMrll1J5reg" name="Distal radius" description="Distal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R2" visible="1" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="uTzExOd0hkKms-SUrZsovg" name="FillLevelFlag" description="Fill Level Flag" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Lumen_PKSim.PARAM_FillLevelFlagFlag" visible="0" canBeVaried="1" />
-                      <Parameter id="va44ow3wpEeLEBooAmsWtA" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Lumen_PKSim.PARAM_FillLevel" visible="0" canBeVaried="1" />
-                      <Parameter id="yC2eHcrziEyuDf1hGDTnfg" name="Geometric surface area" description="Geometric surface area of GI segment" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Area" visible="1" canBeVaried="1" displayUnit="cm²" />
-                      <Parameter id="m5RB2ThQvk6kIeooyklBQQ" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0060009" />
-                      <Parameter id="mthB6rl-Z0SqyvT_pq9WgA" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.6886041141" displayUnit="cm" />
-                      <Parameter id="gOHfCof0YUqkKLX7HGRL3w" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0384322177" displayUnit="cm" />
-                      <Parameter id="r-mVWEhvHU29Jf9GAgjFfA" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.08637087" displayUnit="1/cm" />
-                      <Parameter id="2P5U6mPX1kCsPb7JBsfLLA" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0394956146" displayUnit="cm" />
-                      <Parameter id="9SkQLGdrpECJPX_okBMs7g" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0076" displayUnit="cm" />
-                      <Parameter id="FPqS2AV6K0GNMy2GdkD03A" name="Intestinal transit rate" description="Transit rate along intestinal segments" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" visible="0" canBeVaried="1" value="3.3333" displayUnit="1/min" />
-                      <Parameter id="hYlrKgXfJkis8PQLaU8LcQ" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.008955843" />
-                      <Parameter id="dtEGAv56R027GTfetyixlw" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.015672726" />
-                      <Parameter id="4Je0Z2gE_EaNkjCVJtYUeA" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.067256381" displayUnit="cm" />
-                      <Parameter id="vNaHD3EU5EuGu5hHnf9sew" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="5.7" />
-                      <Parameter id="PjEvPQ9eFECFxkLWufAS6w" name="Microvilli factor" description="Microvilli factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                      <Parameter id="uQhev0hgLU2znFjvFmMxhw" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.144607745" />
-                      <DistributedParameter id="_sZIPmV9lkGren6zHhyVKQ" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="D5U85nbrl0KGV9gbw85u9A" mode="Logical" visible="1">
-                        <Children>
-                          <Parameter id="gv-VIaUqakmLAQA25SdcYQ" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                          <Parameter id="ek5Udv6FSEqer6vkHbeAGw" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="2.5" />
-                        </Children>
-                      </DistributedParameter>
-                      <Container id="RkXFSuxegE6TC756FHtn7Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                        <Children>
-                          <Parameter id="KZl-P-RUhkWX2dFG0HWctw" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" visible="0" canBeVaried="0" />
-                          <Parameter id="GbRtjvCmA0iKIepcBZDItA" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" visible="0" canBeVaried="0" />
-                          <Parameter id="J33_qWrWsEartYO66vNfUQ" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" visible="0" canBeVaried="0" />
-                          <Parameter id="c1dcxag-8UOMMHZ5OMdbEw" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" visible="0" canBeVaried="0" />
-                          <Parameter id="5JmTFAq_6UixI7FJ5Yx_Yg" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" visible="0" canBeVaried="0" />
-                          <Parameter id="wCBdXG-G3UWA34D38I0pMw" name="Solubility" description="Solubility" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" formula="Lumen_PKSim.PARAM_IntestinalSolubility" visible="1" canBeVaried="1" displayUnit="mg/l" />
-                          <Parameter id="019zEw9TNE6Ed8u-BJhuVw" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" visible="0" canBeVaried="0" />
-                          <Parameter id="8ecyYQ2RxUiOeZtlhNqYzA" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" visible="0" canBeVaried="0" />
-                          <Parameter id="PmlalUHQ2UGb3FcUGNvTRg" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" visible="0" canBeVaried="0" />
-                          <Parameter id="rnD1qKiD80u_LL2VBapK1g" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" visible="0" canBeVaried="0" />
-                          <Parameter id="ghBNG6T4WUK8Vq35hkZ1bA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal_GI" visible="0" canBeVaried="0" />
-                          <Parameter id="nw1gan1rpEalWI7Ndyju2A" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" visible="0" canBeVaried="0" rHSFormula="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_coltrans" value="0" displayUnit="µmol" />
-                          <Parameter id="P9XC-Dqw8kif-HD8FjjXKw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="0" value="1" />
-                          <Parameter id="SR56aK-GyEWez064RGUcoQ" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" visible="0" canBeVaried="0" />
-                          <Parameter id="_2qzgQJREE-LLir0cNnprw" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" visible="0" canBeVaried="0" />
-                          <Parameter id="Joinae4GTk-OuwWtm21NyQ" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" visible="0" canBeVaried="0" />
-                        </Children>
-                      </Container>
-                    </Children>
-                  </Container>
-                  <Container id="TQQ1m1iJG0CQmvlfvaPkuA" name="ColonDescendens" description="Colon Descendens / Distal Colon 1" icon="ColonDescendens" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Lumen" />
-                      <Tag value="LumenSegment" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="JPPbis0Vgk2Gn_FzQPbeJw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="2q6TBXJk6kClLPMl9SkuEA" name="FillLevelFlag" description="Fill Level Flag" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Lumen_PKSim.PARAM_FillLevelFlagFlag" visible="0" canBeVaried="1" />
-                      <Parameter id="CxeiFTtup0qjTweJcTmdvw" name="Volume (gut wall)" description="Volume of the gut wall" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="MucosaVolume_Human.PARAM_VolumeGutWall_ColonDescendens" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Parameter id="WWBaKgnndkeL-bzpfS6jdQ" name="Distal radius" description="Distal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R2" visible="1" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="bwkDiCqf10aMf5-nqion7Q" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Lumen_PKSim.PARAM_FillLevel" visible="0" canBeVaried="1" />
-                      <Parameter id="lZ5K6zuN_EKybNuJT47Idw" name="Geometric surface area" description="Geometric surface area of GI segment" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Area" visible="1" canBeVaried="1" displayUnit="cm²" />
-                      <Parameter id="3b_esGVtAEmGV3CsphyQAQ" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_InverseLITT_Factor_ColonDescendens" visible="0" canBeVaried="1" displayUnit="1/min" />
-                      <Parameter id="ZePc7CQyZUevbMFRf73oHw" name="Length" description="Length" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Length" visible="1" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="LMNHKDp86USSPKhw7QO1CQ" name="Liquid" description="Liquid" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Liquid_StartValue" visible="0" canBeVaried="1" rHSFormula="Lumen_PKSim.LiquidRHS_coldesc" displayUnit="l" />
-                      <Parameter id="r6rGdVtJZEqC0AXGrh7jDg" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Lumen_PKSim.PARAM_LiquidTransferRate_coldesc" visible="0" canBeVaried="0" displayUnit="l/min" />
-                      <Parameter id="J3vIX6TKcE64d0k7dj3-Vg" name="Proximal radius" description="Proximal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R1" visible="1" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="s05fQHumS0ePq2aBsxgLbQ" name="Secretion of liquid" description="Rate of liquid inflow" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Inflow_ColonDescendens" visible="0" canBeVaried="1" displayUnit="l/min" />
-                      <Parameter id="OK211TNrxUSDj2lZ_PAWnw" name="Thickness of gut wall" description="Thickness of Gut Wall" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Thickness" visible="0" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="7EuxnfjxekidTLHrqPlImA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_LumenSegment" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Parameter id="bJMrKyEa_UmFYjDgmkhSIQ" name="Absorption of liquid" description="rate of liquid outflow" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Outflow_ColonDescendens" visible="0" canBeVaried="1" displayUnit="1/min" />
-                      <Parameter id="8pZqE7Ew9EufC3lZulK6xw" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0384322177" displayUnit="cm" />
-                      <Parameter id="mheDbwTcAUifEXcxUgQ95w" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.008955843" />
-                      <Parameter id="kf6bOgmP5Eq56RH_I2Q8zA" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0384322177" displayUnit="cm" />
-                      <Parameter id="NMvkPOeffUepBCJBsQoMAg" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="6.6" />
-                      <Parameter id="Dv5Y2WSdcUG3SwJxUBSeLQ" name="Microvilli factor" description="Microvilli factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                      <Parameter id="K1-dnJPe4kagqDIRz1Sv-g" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.098514277" />
-                      <Parameter id="6HTC_22umkGK7owYRG8uCw" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.4227543951" displayUnit="cm" />
-                      <Parameter id="xDueeX37Rk-lcgYyr0M7Ug" name="Intestinal transit rate" description="Transit rate along intestinal segments" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" visible="0" canBeVaried="1" value="5" displayUnit="1/min" />
-                      <Parameter id="dPeDH9iJa0OaRC0lzpYhug" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.008955843" />
-                      <Parameter id="CAQoaHWi-kSqLaKsV511SQ" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.08977747" displayUnit="1/cm" />
-                      <Parameter id="cpwe1pz8pUu3f-kV9seMTw" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0601543776" displayUnit="cm" />
-                      <Parameter id="7abQHH2kYUKe78hQFALocw" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0118" displayUnit="cm" />
-                      <Parameter id="Re0TpYGIdke80p9DSAdWsw" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0060009" />
-                      <DistributedParameter id="RQ0B8C2KbU23zsvv_ZcWaA" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="kqo1eEwQOEOjH8pvaWibwg" mode="Logical" visible="1">
-                        <Children>
-                          <Parameter id="nvIWDjeyOUenSvvVl5ZVXA" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                          <Parameter id="p-_B7NVEBU6mXptOnDMIwA" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="2.5" />
-                        </Children>
-                      </DistributedParameter>
-                      <Container id="R-pqh30XUUK6QpD6-HXIWg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                        <Children>
-                          <Parameter id="rdV2_HsRjECElmq8P-XlKw" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" visible="0" canBeVaried="0" />
-                          <Parameter id="syeOci9eX0KuGQNBiwmo3A" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" visible="0" canBeVaried="0" />
-                          <Parameter id="XH7ZSd4MUUupTDFpIyWTKA" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" visible="0" canBeVaried="0" />
-                          <Parameter id="MxfDt0IYdkivgPxJmgux8g" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" visible="0" canBeVaried="0" />
-                          <Parameter id="75w5SSZk7k2ZWBchy4m1HQ" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" visible="0" canBeVaried="0" />
-                          <Parameter id="aP4YDBAG9UmqLW8rLMZ45w" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" visible="0" canBeVaried="0" />
-                          <Parameter id="4xYHk0nu7kmrhbl9eMqnwA" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" visible="0" canBeVaried="0" />
-                          <Parameter id="BHugHV38EEKrsYL-8fqyFw" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" visible="0" canBeVaried="0" />
-                          <Parameter id="QsGsdilvbUafR00_zz62qQ" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" visible="0" canBeVaried="0" rHSFormula="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_coldesc" value="0" displayUnit="µmol" />
-                          <Parameter id="A1_2XuGWh0ydeFL3smRidA" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" visible="0" canBeVaried="0" />
-                          <Parameter id="JlcYFtfDiESu_ddErUVKTg" name="Solubility" description="Solubility" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" formula="Lumen_PKSim.PARAM_IntestinalSolubility" visible="1" canBeVaried="1" displayUnit="mg/l" />
-                          <Parameter id="9RZeIsRrGUC398cehNn8vQ" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" visible="0" canBeVaried="0" />
-                          <Parameter id="lxp1K_PUvUigoWkcEIiH1A" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" visible="0" canBeVaried="0" />
-                          <Parameter id="dSyK-ssDVky6bZqJL4P63A" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" visible="0" canBeVaried="0" />
-                          <Parameter id="KH9JE-CD7keusGhpi1PMGg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="0" value="1" />
-                          <Parameter id="UW49vSXPRkiQF5lplkd2rg" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal_GI" visible="0" canBeVaried="0" />
-                        </Children>
-                      </Container>
-                    </Children>
-                  </Container>
-                  <Container id="pXPUliiKakqWhra3psEI6A" name="ColonSigmoid" description="Colon Sigmoid / Distal Colon 2" icon="ColonSigmoid" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Lumen" />
-                      <Tag value="LumenSegment" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="YsjLT6nVBkyuiuc50NYxTw" name="Thickness of gut wall" description="Thickness of Gut Wall" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Thickness" visible="0" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="80duGiPweE6T_db8lbmMjw" name="Absorption of liquid" description="rate of liquid outflow" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Outflow_ColonSigmoid" visible="0" canBeVaried="1" displayUnit="1/min" />
-                      <Parameter id="Gm1tTQsomkyQGALOQV_FDw" name="Distal radius" description="Distal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R2" visible="1" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="G_05qeVMLUi-Yv-xOXBhzw" name="FillLevelFlag" description="Fill Level Flag" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Lumen_PKSim.PARAM_FillLevelFlagFlag" visible="0" canBeVaried="1" />
-                      <Parameter id="Z6CbSZBRUESnXvBH9OgoKA" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Lumen_PKSim.PARAM_FillLevel" visible="0" canBeVaried="1" />
-                      <Parameter id="bJHN7B0lhE6XfMcwZtzGbQ" name="Geometric surface area" description="Geometric surface area of GI segment" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Area" visible="1" canBeVaried="1" displayUnit="cm²" />
-                      <Parameter id="uuzLgg7asUmInJ6v0eeIjw" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_InverseLITT_Factor_ColonSigmoid" visible="0" canBeVaried="1" displayUnit="1/min" />
-                      <Parameter id="I78kEk90ukelVcoLJVXkIg" name="Length" description="Length" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Length" visible="1" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="sdAYqWoqAU2xY76KPK3ADA" name="Liquid" description="Liquid" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Liquid_StartValue" visible="0" canBeVaried="1" rHSFormula="Lumen_PKSim.LiquidRHS_colsigm" displayUnit="l" />
-                      <Parameter id="rDOZfPXSJkGLg9mJoLua9w" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Lumen_PKSim.PARAM_LiquidTransferRate_colsigm" visible="0" canBeVaried="0" displayUnit="l/min" />
-                      <Parameter id="gjs5TG2XKUWL9jw_WJEl6w" name="Proximal radius" description="Proximal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R1" visible="1" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="QJLVo71EPkSkgPPQNK6Etg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_LumenSegment" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Parameter id="xZsoMHEoPEC9OHB5WAL0Og" name="Volume (gut wall)" description="Volume of the gut wall" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="MucosaVolume_Human.PARAM_VolumeGutWall_ColonSigmoid" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Parameter id="_H41YSQ9V0mBjSPMyAy-uw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="mGnM1yjbn0-HCwxDhja_0Q" name="Secretion of liquid" description="Rate of liquid inflow" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Inflow_ColonSigmoid" visible="0" canBeVaried="1" displayUnit="l/min" />
-                      <Parameter id="V6Pw2aM8MUOt-yet8vBDUA" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0384322177" displayUnit="cm" />
-                      <Parameter id="h_9d6veLskm8zroduvw-bQ" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0889014" displayUnit="1/cm" />
-                      <Parameter id="YBckwuTmOEG7KwHBbmXQBA" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0274432593" displayUnit="cm" />
-                      <Parameter id="wzy8vh3oJEGjWy0M6jErGA" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.00536" displayUnit="cm" />
-                      <Parameter id="Z-XahOfxik2Nn5QEDvlDJQ" name="Intestinal transit rate" description="Transit rate along intestinal segments" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" visible="0" canBeVaried="1" value="4.0741" displayUnit="1/min" />
-                      <Parameter id="GU6ejEeLDE2yhvffdGL4kw" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.008955843" />
-                      <Parameter id="zQoae5KsGkO3-jzzEjf5Ug" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0384322177" displayUnit="cm" />
-                      <Parameter id="GebMMpBYTEWzW1lZe0jxLg" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="6.6" />
-                      <Parameter id="iSuSGlWC8kW28RTcOBDD-g" name="Microvilli factor" description="Microvilli factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                      <Parameter id="czTe5iyWG0mwxn-VaVpFeA" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.121300709" />
-                      <Parameter id="2ssQPm08tk-EUyEasD9oDw" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.008955843" />
-                      <Parameter id="Wnn3JO5H2UGu5Vu_cFgfdA" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5337898629" displayUnit="cm" />
-                      <Parameter id="8vhZJ7rYAkinhCYKa6pi7Q" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0060009" />
-                      <DistributedParameter id="W_TukGPM-kqTUIl_jOLCWg" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="qmmQKfipOUumylARX1ZrIQ" mode="Logical" visible="1">
-                        <Children>
-                          <Parameter id="3sxId5YMYUmnE2SnJFT04Q" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                          <Parameter id="VCK3GBALAkiQtLx6lRe3DA" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="2.5" />
-                        </Children>
-                      </DistributedParameter>
-                      <Container id="yRzo1ictaES6H13zffgEvA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                        <Children>
-                          <Parameter id="6aDeiMnC4UubtLcnn-2Tqg" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" visible="0" canBeVaried="0" />
-                          <Parameter id="qrRzL19REE6Xu1T6Oa-WTw" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" visible="0" canBeVaried="0" />
-                          <Parameter id="9NUpSpu1DUm0MznodYaYhA" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" visible="0" canBeVaried="0" />
-                          <Parameter id="RsbYFJvz1k-dYsCBtmtfRQ" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" visible="0" canBeVaried="0" />
-                          <Parameter id="W3cHRvqN4UGZeHAcj5aUnA" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" visible="0" canBeVaried="0" />
-                          <Parameter id="sBswIJi_RESVWEFIJnydvA" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" visible="0" canBeVaried="0" />
-                          <Parameter id="2HgSSFsBvEqQXjb7Ht53hQ" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" visible="0" canBeVaried="0" />
-                          <Parameter id="VxA_6HPSGk-BUqWGApij1Q" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" visible="0" canBeVaried="0" />
-                          <Parameter id="IC2p0knMc0eYhMlV92Q81A" name="Solubility" description="Solubility" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" formula="Lumen_PKSim.PARAM_IntestinalSolubility" visible="1" canBeVaried="1" displayUnit="mg/l" />
-                          <Parameter id="djNxWx98mEKJDDuV4AyN2Q" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" visible="0" canBeVaried="0" />
-                          <Parameter id="Kn_MXnXpv0KnJoq_qoNy-g" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" visible="0" canBeVaried="0" />
-                          <Parameter id="lUiJEQR6tEmBlVFc1wGaHQ" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" visible="0" canBeVaried="0" />
-                          <Parameter id="1B6Ul5UgN0mQdASKPWnAyQ" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal_GI" visible="0" canBeVaried="0" />
-                          <Parameter id="7rJvGMajGE2MfG_AmbrpXw" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" visible="0" canBeVaried="0" rHSFormula="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_colsigm" value="0" displayUnit="µmol" />
-                          <Parameter id="Ymvaw4xS8UmXOHBEprVcAg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="0" value="1" />
-                          <Parameter id="H5xmNMFmGkS855PBnoQy1g" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" visible="0" canBeVaried="0" />
-                        </Children>
-                      </Container>
-                    </Children>
-                  </Container>
-                  <Container id="tl7DiBQWEUGwcvPUXLf68w" name="Rectum" description="Rectum" icon="Rectum" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Lumen" />
-                      <Tag value="LumenSegment" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="YlXgaX0SZUO_72WirfTg5Q" name="Length" description="Length" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Length" visible="1" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="xVj1VWPUQkiACNLMA52bWw" name="Absorption of liquid" description="rate of liquid outflow" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Outflow_Rectum" visible="0" canBeVaried="1" displayUnit="1/min" />
-                      <Parameter id="PsSmN87CSEGZaTFs1ns-sA" name="Distal radius" description="Distal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R2" visible="1" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="JrnTqYh7pk2RjYA6HDydwQ" name="FillLevelFlag" description="Fill Level Flag" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Lumen_PKSim.PARAM_FillLevelFlagFlag" visible="0" canBeVaried="1" />
-                      <Parameter id="69NR94g5F0y9qTMbzMkPnw" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Lumen_PKSim.PARAM_FillLevel" visible="0" canBeVaried="1" />
-                      <Parameter id="aacNf71BTEuUuiKxe849xg" name="Geometric surface area" description="Geometric surface area of GI segment" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Area" visible="1" canBeVaried="1" displayUnit="cm²" />
-                      <Parameter id="ZgTYQBhWHkyVlAhhVqP68Q" name="Liquid" description="Liquid" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Liquid_StartValue" visible="0" canBeVaried="1" rHSFormula="Lumen_PKSim.LiquidRHS_rect" displayUnit="l" />
-                      <Parameter id="MO3YURFIsU-2FZCq8O4XNA" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_InverseLITT_Factor_Rectum" visible="0" canBeVaried="1" displayUnit="1/min" />
-                      <Parameter id="Wvh-zZ8YLE6tQQhKN_ZWBw" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Lumen_PKSim.PARAM_LiquidTransferRate_rect" visible="0" canBeVaried="0" displayUnit="l/min" />
-                      <Parameter id="HkYmf5I1zkOgF6yvtq4HDw" name="Proximal radius" description="Proximal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R1" visible="1" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="oqmbPP12YkCcI2d5QdFgIw" name="Secretion of liquid" description="Rate of liquid inflow" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Inflow_Rectum" visible="0" canBeVaried="1" displayUnit="l/min" />
-                      <Parameter id="aCR3ED5PKUKj0WwoO3IRaw" name="Thickness of gut wall" description="Thickness of Gut Wall" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Thickness" visible="0" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="SelVqTz8D0GhOwZkoLLYWw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_LumenSegment" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Parameter id="DNC8fUvhpkmJpWcht3wEcg" name="Volume (gut wall)" description="Volume of the gut wall" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="MucosaVolume_Human.PARAM_VolumeGutWall_Rectum" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Parameter id="68D8yfnNMUSyjqMarnw7Jg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="lcrwGmpwHEaZuy-eTSwQyQ" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0060009" />
-                      <Parameter id="T0PJXS5KdEGw179dHZLRKQ" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0324721331" displayUnit="cm" />
-                      <Parameter id="tEJL2rnKBUOGu7ZNsIV5LA" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.00665" displayUnit="cm" />
-                      <Parameter id="eN5lTtLC_k2QcGMWd5QQIg" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.005597402" />
-                      <Parameter id="6pxTokB51EeL1-UwJx1U1Q" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0240201361" displayUnit="cm" />
-                      <Parameter id="-z2E2ep5mUa7PSbnFivZyQ" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.008955843" />
-                      <Parameter id="GB8obBOiMkOWJnygDOnVEw" name="Intestinal transit rate" description="Transit rate along intestinal segments" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" visible="0" canBeVaried="1" value="315.618" displayUnit="1/min" />
-                      <Parameter id="e44ieTMvjEmj3YLmcothDg" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.1569046761" displayUnit="cm" />
-                      <Parameter id="JRM8Su2tQEmydiznHFCCVA" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="6.6" />
-                      <Parameter id="UIsx4W4TAEe-Vzlza8LB_Q" name="Microvilli factor" description="Microvilli factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                      <Parameter id="bu39yV-zz0KR9R9agG47AA" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.052420808" />
-                      <Parameter id="aLkKO2jsSkK8KE8Q2ENp8Q" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0384322177" displayUnit="cm" />
-                      <Parameter id="Gd_vpodpQke2WC0ubguO6Q" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.10014267" displayUnit="1/cm" />
-                      <DistributedParameter id="8DVvyVzGIUS0ET6V7IrNCw" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="QhMDrLLqME6_kdhC0-2gEw" mode="Logical" visible="1">
-                        <Children>
-                          <Parameter id="hVn8QGTYVEGh7e9GKUnLew" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                          <Parameter id="oU3n1PIKtkeZfCo8zmMbOw" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="3.56" />
-                        </Children>
-                      </DistributedParameter>
-                      <Container id="DqsgrYovFESGgnpDM2L4Bg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                        <Children>
-                          <Parameter id="m-ZgEIoUckuUBd8JUt4FjA" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" visible="0" canBeVaried="0" rHSFormula="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_rect" value="0" displayUnit="µmol" />
-                          <Parameter id="LbqxGhB-ykmbTRcba_zQOw" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" visible="0" canBeVaried="0" />
-                          <Parameter id="g4UD4MsknkyQsoq6lIRQ1g" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" visible="0" canBeVaried="0" />
-                          <Parameter id="xXub-m6Ow0unhEKyuZ1zqQ" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" visible="0" canBeVaried="0" />
-                          <Parameter id="Gt22bDsAtkG5ITY-C8xr2g" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" visible="0" canBeVaried="0" />
-                          <Parameter id="q6ljMOztkEmG_AP8xot7oQ" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" visible="0" canBeVaried="0" />
-                          <Parameter id="h5LptsJD1UGOd3A6Fa3DLw" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" visible="0" canBeVaried="0" />
-                          <Parameter id="NPrPiT9n90SkJLdeOoyIGw" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" visible="0" canBeVaried="0" />
-                          <Parameter id="iofUkf6X3UmYFDLPladKBA" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" visible="0" canBeVaried="0" />
-                          <Parameter id="DH0ef0OARkWL0awIFclX8g" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" visible="0" canBeVaried="0" />
-                          <Parameter id="Y2Hv951DXUancXBohrcaog" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" visible="0" canBeVaried="0" />
-                          <Parameter id="AiegBU2xU0iDMxil9qTdZA" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" visible="0" canBeVaried="0" />
-                          <Parameter id="e-Ijoe_dx0yqZD1HMV8kkA" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" visible="0" canBeVaried="0" />
-                          <Parameter id="3A-xz8MRF0WEny7HVBMjLA" name="Solubility" description="Solubility" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" formula="Lumen_PKSim.PARAM_IntestinalSolubility" visible="1" canBeVaried="1" displayUnit="mg/l" />
-                          <Parameter id="h0Nz4rlcz0ayJlv5ev5MiA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal_GI" visible="0" canBeVaried="0" />
-                          <Parameter id="OiHyRUAZQU6jA0BIKWheYw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="0" value="1" />
-                        </Children>
-                      </Container>
-                    </Children>
-                  </Container>
-                  <Container id="bhSAzpl7HkaX9dPtBlqhGQ" name="Feces" description="Feces compartment used to collect the fraction excreted of the compound from the instestinal wall into the gut lumen." mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Lumen" />
-                      <Tag value="LumenSegment" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="ey87j1hB1UqjWJBuFnB4hQ" name="Liquid" description="Liquid" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" rHSFormula="Lumen_PKSim.LiquidRHS_fec" value="0" displayUnit="l" />
-                      <Parameter id="RwxkyL8CtE60Vx3nybg5Rg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="l" />
-                    </Children>
-                  </Container>
-                </Children>
-              </Container>
-              <Container id="W9QLxnnS7UiEKTcDH8G9OA" name="Stomach" description="Stomach" icon="Stomach" mode="Logical" containerType="Organ">
-                <Tags>
-                  <Tag value="Portal Vein Supplying Organ" />
-                  <Tag value="TissueOrgan" />
-                </Tags>
-                <Children>
-                  <Parameter id="cCHAGjhjyUuJfsAaHHP5xA" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="Individual_PKSim.PARAM_Tissue_Weight" visible="0" canBeVaried="1" displayUnit="kg" />
-                  <Parameter id="P-DLfwWLMkq15SJElgM9Dg" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="VascularEndoVolume.VOLUME_VascularEndo_sto" visible="1" canBeVaried="0" displayUnit="l" />
-                  <Parameter id="L-y4dgIbGke44txJy2bKLQ" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Lymph_flow_rate_Stomach" visible="1" canBeVaried="1" displayUnit="l/min" />
-                  <Parameter id="cA5-5dqSR0i6Q_Z-915_7Q" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate_Stomach" visible="1" canBeVaried="1" displayUnit="l/min" />
-                  <Parameter id="EQ6hEd3EJESeimlOHmEjrg" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_f_cell" visible="1" canBeVaried="1" />
-                  <Parameter id="gLHvc3ybgUGJ0Pbo3FLWzw" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Q_from_Qspec" visible="1" canBeVaried="1" displayUnit="l/min" />
-                  <Parameter id="KsBSXPR02U25G3EkuLPvaw" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                  <Parameter id="5ONtsDqF_kSJ2_xjLcWpPA" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.75" />
-                  <Parameter id="YiPJvXqag0Ksw-7N84fq2g" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                  <Parameter id="HpKS4t-uOE-z43njf5g73Q" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="4.5E-08" displayUnit="µm" />
-                  <Parameter id="8iD8qPQ1bki0-DFpyd3U6A" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="2.5E-07" displayUnit="µm" />
-                  <Parameter id="ImnZG9AuJkm7wdBEjq723A" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" visible="1" canBeVaried="1" value="3.97222222222222E-11" displayUnit="ml/min/N" />
-                  <Parameter id="XnTyUwMOcEK6G2tJ51QKZw" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.05" />
-                  <Parameter id="8sApSb3IwUKWYqyH9PBiIA" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0487" />
-                  <Parameter id="YRPw_bDQ7UaKhfbZ8TdVCg" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.062" />
-                  <Parameter id="DtS5aOA0RkuBIRlIuJTbBA" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.032" />
-                  <Parameter id="mjfNuA6fRU2wTTvxVWpZjg" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.133" />
-                  <Parameter id="VoNzfU7nVUGRtC_ODHSI5A" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0163" />
-                  <Parameter id="eUDYrHvtRU2x0x2yXKYpuw" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.718" />
-                  <Parameter id="eJzA-X6aSUO1xEHurAKN1g" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.792" />
-                  <Parameter id="v7-bEq-v0kqWMiqic5bEVQ" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.158" />
-                  <Parameter id="vIxTwLdh8U-KvBu_vhF0ng" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.141" />
-                  <Parameter id="PthIXoFXVUO9dvWj2svfjA" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-                  <Parameter id="rUbuTiAZBE2EONIBxiBMzQ" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.1" />
-                  <Parameter id="Kk-I9AjZYUmLjXeVDKmBkw" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0483" />
-                  <Parameter id="L8o30Eux50KKGTghziE3XQ" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0375" />
-                  <Parameter id="qES43LlhwkGR2bIykYnamQ" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0182" />
-                  <Parameter id="P7wjYtKEn0uzvUkzNpaXnQ" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0124" />
-                  <Parameter id="dFP73tri9UaZo7U8Oyx_8g" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.282" />
-                  <Parameter id="DBWN0iE8gU-G8_QT8bVBYA" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.15" />
-                  <Parameter id="smwWenkemEeUFY7g3N_0GQ" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.78" />
-                  <Parameter id="wwv97_rCxka6mw0ZEZbVug" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.456" />
-                  <Parameter id="J7GwrTm4E0CPHheN3XqbAg" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0035" />
-                  <Parameter id="KQJA-zKcpUy4EkGXnz0RPw" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="2.41" />
-                  <DistributedParameter id="_0ETAhvtjEmaHJXeVDdgGw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="IrEpekZ0y0ChdmYHyVh2Qg" mode="Logical" visible="1" displayUnit="l">
-                    <Children>
-                      <Parameter id="t6pU14V9zkW8iKE-Ssn8FQ" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.500397173769471" displayUnit="l" />
-                      <Parameter id="Gs-jxjzqEUuRfqTjVlQN6w" name="Mean" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" value="0.135729408786912" displayUnit="l" />
-                      <Parameter id="00dkCAdw3Eel3xlBIaRGHw" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0203594113180368" displayUnit="l" />
-                    </Children>
-                  </DistributedParameter>
-                  <DistributedParameter id="Ap4MZ8D5wkiQNqM8T9mCCA" name="Specific blood flow rate" description="Blood flow rate normalized to the organ volume" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" formula="W9wr-L44V067gUs4MkrARA" mode="Logical" visible="1" displayUnit="ml/min/100g organ">
-                    <Children>
-                      <Parameter id="AIoaeTd-IESD42uGZoNp-Q" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" displayUnit="ml/min/100g organ" />
-                      <Parameter id="4jeiAvOivEOY8mZcxDYTMg" name="Mean" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" visible="0" canBeVaried="1" value="0.3861" displayUnit="ml/min/100g organ" />
-                      <Parameter id="N8l4m6NtTky228_bMzR7kg" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" visible="0" canBeVaried="1" value="0.019305" displayUnit="ml/min/100g organ" />
-                    </Children>
-                  </DistributedParameter>
-                  <Container id="wcVwGWqUikGrxah1-6Vx6A" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Portal Vein Supplying Organ" />
-                      <Tag value="Stomach" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="2iKsdVhwiEuvHgYd2UJSDg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="dNTWo5H3dEuS36IH1hFPhw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Container id="jfthzMPt0UemB0VRdWo15Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                        <Children>
-                          <Parameter id="e2FS3xQHTkiLFBF5An7B0A" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                          <Parameter id="XdyoCPVrCU2_3AG5xb0-dg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" visible="0" canBeVaried="0" />
-                        </Children>
-                      </Container>
-                    </Children>
-                  </Container>
-                  <Container id="ZsgRGsl2Ika6nIUVelD34g" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Portal Vein Supplying Organ" />
-                      <Tag value="Stomach" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="2MdA68k-vEGFNxXAwAiZfw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="POnhDS1bb0Kwn-FCYZtDXA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Container id="a6BeVPKQ2kqox1tFvfKoXA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                        <Children>
-                          <Parameter id="DCLzhaBnuUG3Cf_UPbBUgw" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                          <Parameter id="LHdDajn9W0WIx_WJtRY74w" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" visible="0" canBeVaried="0" />
-                        </Children>
-                      </Container>
-                    </Children>
-                  </Container>
-                  <Container id="pkdR9CiDHEq7nh4GTlLyVA" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Portal Vein Supplying Organ" />
-                      <Tag value="Stomach" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="l7r1FOJCW06SaknVJmpX_Q" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="f_TfHaCeuUiEmZgpSashCA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Parameter id="5Om6q_jdCkiNNRIMWC-CUQ" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_pH_INT" visible="1" canBeVaried="1" />
-                      <Container id="g1J10NpFNEmBlO59g2jo2Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                        <Children>
-                          <Parameter id="V3yDGIVtC0WgBLvdRXsOVw" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                          <Parameter id="4a1zb29KUEWt-INvFfYuYw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_sto" visible="0" canBeVaried="0" />
-                        </Children>
-                      </Container>
-                    </Children>
-                  </Container>
-                  <Container id="Mur3m3tL10Ga-Q6Mn5phPg" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Portal Vein Supplying Organ" />
-                      <Tag value="Stomach" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="ilf7CNAYREiFSGwOlAOH9A" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="uEaIcua-tUuaDTa3QHtY9Q" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Parameter id="SdSGm3yme02xEQG6R5sF1A" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.4" />
-                      <Container id="U183ynwmeUya0vGmYyos1w" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                        <Children>
-                          <Parameter id="YXjk1Cs02kWm9_WoDaSFUA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                          <Parameter id="8qiBq0nC6kOyA-22xjZszg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_sto" visible="0" canBeVaried="0" />
-                        </Children>
-                      </Container>
-                    </Children>
-                  </Container>
-                </Children>
-              </Container>
-              <Container id="_Ea-hm3uwEOFN5aefJGDLA" name="SmallIntestine" description="SmallIntestine" icon="SmallIntestine" mode="Logical" containerType="Organ">
-                <Tags>
-                  <Tag value="Portal Vein Supplying Organ" />
-                  <Tag value="TissueOrgan" />
-                </Tags>
-                <Children>
-                  <Parameter id="OZsXfD9wK0Gn6SLmLS79Vw" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="Individual_PKSim.PARAM_Tissue_Weight" visible="0" canBeVaried="1" displayUnit="kg" />
-                  <Parameter id="KSWj1kDT1EC3tDScTtFCmQ" name="Small intestinal transit time factor" description="Small intestinal transit time factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Lumen_PKSim.PARAM_SITT_Factor" visible="0" canBeVaried="1" />
-                  <Parameter id="emDHR4kTg0-WE7hpIj0Zbg" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Q_Lymph_sin" visible="1" canBeVaried="0" displayUnit="l/min" />
-                  <Parameter id="9Ci8B3VY3kKpg-mJTk1YVw" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="VascularEndoVolume.VOLUME_VascularEndo_sin" visible="1" canBeVaried="0" displayUnit="l" />
-                  <Parameter id="Wrn-iltJ8EiP1fmKUZWaAg" name="Lymph flow rate (incl. mucosa)" description="Lymph flow rate (incl. mucosa)" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Lymph_flow_rate_(incl._mucosa)_SmallIntestine" visible="1" canBeVaried="1" displayUnit="l/min" />
-                  <Parameter id="aB_X3VldU0Kdnh-AEgMFYA" name="Fluid recirculation flow rate (incl. mucosa)" description="Fluid recirculation flow rate between plasma and interstitial space (incl. mucosa)" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate_(incl._mucosa)_SmallIntestine" visible="1" canBeVaried="1" displayUnit="l/min" />
-                  <Parameter id="XlnWakV3WkOEegrFbsQHhQ" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_FluidRecirculationRate_sin" visible="1" canBeVaried="0" displayUnit="l/min" />
-                  <Parameter id="tf3UPmubpEus2z2YHXL-XQ" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_f_cell" visible="1" canBeVaried="1" />
-                  <Parameter id="rFv6d3S6y0uusJJ3wuKJfw" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Q_from_Qspec" visible="1" canBeVaried="1" displayUnit="l/min" />
-                  <Parameter id="OJhfMVoJ0E2L_DDxcRcFwg" name="Volume (mucosa)" description="Volume of mucosa" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="MucosaVolume.VOLUME_SmallIntestineMucosa" visible="1" canBeVaried="1" displayUnit="l" />
-                  <Parameter id="_hwx8LBAakeTTO-i_PYoJg" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                  <Parameter id="YgozUXsV2EuSC54mkmxGPQ" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.75" />
-                  <Parameter id="R9Sky5Eqj0K3ddUQPRD_ig" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                  <Parameter id="5KnpCg6VL0iL1E4BDTzdWg" name="Small intestinal transit time factor slope" description="Small intestinal transit time factor slope" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" visible="0" canBeVaried="0" value="0.602" displayUnit="1/min" />
-                  <Parameter id="EIR9PdKEhkS9ZJr_fVThfA" name="Small intestinal transit time factor intercept" description="Small intestinal transit time factor intercept" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="0" value="-4.52" />
-                  <Parameter id="MuGHhFubMUSKQKpnbd-LIg" name="Mucosa blood flow fraction" description="Blood fraction which goes to mucosa" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.75" />
-                  <Parameter id="FKdTk54dT0ajlH43LfJhNA" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="4.5E-08" displayUnit="µm" />
-                  <Parameter id="phn_yo7I9UeKNig5HMcJuQ" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="2.5E-07" displayUnit="µm" />
-                  <Parameter id="i8HwWJTq9kC6FnAKTMfkBA" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" visible="1" canBeVaried="1" value="1.53888888888889E-10" displayUnit="ml/min/N" />
-                  <Parameter id="R1oy6tT3eE28AgptC_FWXw" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.05" />
-                  <Parameter id="n9qm8aFu1k6KSHfZSEhJAQ" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0487" />
-                  <Parameter id="KxUu0fMkY0utNgky4mVArA" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.062" />
-                  <Parameter id="3V74NHaU7kWw9eX1QerMWg" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.024" />
-                  <Parameter id="dP6joaeADkKrV-9m1SfALA" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.133" />
-                  <Parameter id="7qZ4VjR5wkWMFsqnhRWzmQ" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0163" />
-                  <Parameter id="s8FrfwQifkCho7ZmBvUnzw" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.718" />
-                  <Parameter id="EpyVr2AFKE2Sr7tSsQX3yw" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.792" />
-                  <Parameter id="-V0STFwIvUa1TVWCP1yk4A" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.158" />
-                  <Parameter id="K2RXGuJKukmSj55ghjhN6w" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-                  <Parameter id="7c9ebyiKw06ht4qE66SriQ" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.141" />
-                  <Parameter id="6X-WdKTFEkC38uog0AwDcA" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.094" />
-                  <Parameter id="sspGpbzSHk6aS-_zB4V3sQ" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0483" />
-                  <Parameter id="VrBeYMalzkOzgptlmU1PEw" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0375" />
-                  <Parameter id="D9Qwi_fPZk2OVpKiSiHgMQ" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0124" />
-                  <Parameter id="YrqTHRfHQEutYIgix0J2LQ" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0182" />
-                  <Parameter id="E_TEwYy5MUSuaS1fb1kLKg" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.15" />
-                  <Parameter id="9Cmo-htw-UGCe1sNF2aC3g" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.282" />
-                  <Parameter id="UArNFXmzjUSairD_afYltg" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.456" />
-                  <Parameter id="93sOJ-GvMkCnfbchJLTJbQ" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.78" />
-                  <Parameter id="eaQF-cvqSUeVaIFHCa2BfA" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0035" />
-                  <Parameter id="-uB6jIW9m02BupaKQJDJbA" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="2.41" />
-                  <DistributedParameter id="vmstbVr5zUe93VCWHjRW5A" name="Small intestinal transit time" description="The time required for the passage of a non-absorbable compound through the small intestine, defined as the time span between gastric emptying (i.e. the point at which 63% of the drug mass has entered the duodenum) and the time at which 90% has entered the caecum" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" formula="CT81_q1m8kibZgEvnslgZw" mode="Logical" visible="1" displayUnit="h">
-                    <Children>
-                      <Parameter id="GQX39tV7C0u-SMEIi0dwHw" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" displayUnit="h" />
-                      <Parameter id="URvG0hQNhEGB_fNJ92wuFA" name="Mean" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" visible="0" canBeVaried="1" value="126" displayUnit="h" />
-                      <Parameter id="Uv_YlZeS9EW8jOcAbzO0sA" name="GeometricDeviation" description="Geometric standard deviation of LogNormal distribution" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1.6" />
-                    </Children>
-                  </DistributedParameter>
-                  <DistributedParameter id="ip-iWzvUEkyNHJeI5D1dKg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="UxMd-T6oWUKbVPL7l5TuEQ" mode="Logical" visible="1" displayUnit="l">
-                    <Children>
-                      <Parameter id="dqNaN6oyLE--iRnlwIR2-A" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.50153257191455" displayUnit="l" />
-                      <Parameter id="SagLCWmKUUWmUfMaZALvRQ" name="Mean" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" value="0.58335271881664" displayUnit="l" />
-                      <Parameter id="ffkNIzPOaUKJCFwOBtfHbQ" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0682572317087829" displayUnit="l" />
-                    </Children>
-                  </DistributedParameter>
-                  <DistributedParameter id="AKDfft4UFU2cB92i2ZBXNA" name="Specific blood flow rate" description="Blood flow rate normalized to the organ volume" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" formula="E-JBU_WK8kOf1T816pxQ1g" mode="Logical" visible="1" displayUnit="ml/min/100g organ">
-                    <Children>
-                      <Parameter id="grFZXr9YP0u_Epu4-Wl4yQ" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" displayUnit="ml/min/100g organ" />
-                      <Parameter id="voLBJMvbeUaHDilxljpDnQ" name="Mean" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" visible="0" canBeVaried="1" value="0.89765" displayUnit="ml/min/100g organ" />
-                      <Parameter id="48TDpNRKLUCLBC6D4aVFgw" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0448825" displayUnit="ml/min/100g organ" />
-                    </Children>
-                  </DistributedParameter>
-                  <Container id="bKNuXngQSk-SQQe7D3MkAw" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Portal Vein Supplying Organ" />
-                      <Tag value="SmallIntestine" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="yaUOadM960Gm9OojHj5_ww" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="Gq9jTQMjxE-Sl4FdC_luqg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_pls_SinLin" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Container id="EFl2cIHzfk-0Dp1SFrBeLg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                        <Children>
-                          <Parameter id="hc876w2DMk-XXYMefbEqkg" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                          <Parameter id="8FJFuBZu0kS5tufrDLLphQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" visible="0" canBeVaried="0" />
-                        </Children>
-                      </Container>
-                    </Children>
-                  </Container>
-                  <Container id="n6xwS0M17UWg01nLAvRLIQ" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Portal Vein Supplying Organ" />
-                      <Tag value="SmallIntestine" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="NF5tbJ9ShkufqAg3f-Q8Ow" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="5fxflBM6nUa0ixVeurxx5Q" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_bc_SinLin" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Container id="RhJJDln6LEaM-Nc3DxC7EA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                        <Children>
-                          <Parameter id="cP44RnyTiECvTLbMUK0OYA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                          <Parameter id="E8Y4kJzhBUGIW2YIWjDE3Q" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" visible="0" canBeVaried="0" />
-                        </Children>
-                      </Container>
-                    </Children>
-                  </Container>
-                  <Container id="QQEEFQ5iKUyN-6sUySP6Ig" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Portal Vein Supplying Organ" />
-                      <Tag value="SmallIntestine" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="8jc0U-ovREa3qNZZYNnlQA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="YAwXs5KvWU-s1om7bFEPRg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_int_SinLin" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Parameter id="FPrN-u_LcEiMlECWRvMCtw" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_pH_INT" visible="1" canBeVaried="1" />
-                      <Container id="qp-tnDsTkE62q2JDH6Xv1Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                        <Children>
-                          <Parameter id="SYys5K-JrkmLxN5r9LIeyg" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                          <Parameter id="VXYFZtLTnUKaA3uJ9JR13Q" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_sin" visible="0" canBeVaried="0" />
-                        </Children>
-                      </Container>
-                    </Children>
-                  </Container>
-                  <Container id="eTOwNAWOSU2qVPwOLXoz1w" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Portal Vein Supplying Organ" />
-                      <Tag value="SmallIntestine" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="fYgYZ_p9kUSACF8GVBK0yg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ_SinLin" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="jrwV8vzjc0mLYDbQI0u-Mw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_cell_SinLin" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Parameter id="78qznXrnVUyFOXTmuDHTWg" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.4" />
-                      <Container id="Q98iG_DO2UWl8noBNbl81Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                        <Children>
-                          <Parameter id="e5OgQU6K7UWpEnhHPse3UQ" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                          <Parameter id="1FvnQJWUGE-dEta7dGTAEg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_sin" visible="0" canBeVaried="0" />
-                        </Children>
-                      </Container>
-                    </Children>
-                  </Container>
-                  <Container id="1BiQUG4N_kaCCjAnOK4Mbg" name="Mucosa" description="Mucosa" mode="Logical" containerType="Compartment">
-                    <Children>
-                      <Container id="WBQ34pZOtUKe5yiyOlzvFg" name="Duodenum" description="Duodenum" icon="Duodenum" mode="Logical" containerType="Compartment">
-                        <Children>
-                          <Parameter id="RXmxohnS_k6PoAJbu0D6-w" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="Individual_PKSim.PARAM_Tissue_Weight" visible="0" canBeVaried="1" displayUnit="kg" />
-                          <Parameter id="Un0yBWeyd06Vv9QRDnIUMA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="MucosaVolume.VOLUME_MucosaDuodenum" visible="1" canBeVaried="1" displayUnit="l" />
-                          <Parameter id="1_l80-8v_0e1kWgqYBZJOQ" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="VascularEndoVolume.VOLUME_VascularEndo_duo" visible="1" canBeVaried="0" displayUnit="l" />
-                          <Parameter id="JvefbLGQx0iSsIijaAoqew" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Q_lymph_mucosa" visible="1" canBeVaried="1" displayUnit="l/min" />
-                          <Parameter id="3jRx_XCKA0GcO1ZSlfmZew" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_J_iso_Mucosa" visible="1" canBeVaried="1" displayUnit="l/min" />
-                          <Parameter id="cEkuoikfkkq4jU-LIRcRYw" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Q_mucosa" visible="1" canBeVaried="1" displayUnit="l/min" />
-                          <Parameter id="1roxrSN2W0uqJhWq7Ejx7A" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_f_cell" visible="1" canBeVaried="1" />
-                          <Parameter id="WoZwi4nuoEKGEtDa_2nQiQ" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                          <Parameter id="377aJ6FYGUihewBcZDij7w" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                          <Parameter id="jDd4JU5qqUygP7fE4TyUTw" name="Fraction of regional blood flow rate" description="Regional blood flow fraction supplying the mucosal tissue of the segment" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.093" />
-                          <Parameter id="Eq0tMzGbLkSZU1g4t8CJug" name="Fraction mucosa" description="Mucosal fraction of regional intestinal tissue mass" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.26" />
-                          <Parameter id="-FyBDtM6RECOyKnSoekG7g" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" visible="1" canBeVaried="1" value="1.53888888888889E-10" displayUnit="ml/min/N" />
-                          <Parameter id="3EsOzh-9rka5GpWClZXlWw" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="2.5E-07" displayUnit="µm" />
-                          <Parameter id="EC0zxXkdjkCJFmrP48PlIg" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.05" />
-                          <Parameter id="acLx7Dccd0qlVdzT1YUrEA" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="4.5E-08" displayUnit="µm" />
-                          <Parameter id="jpqU61Qpwk2DVQ3KfmW7HA" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.06" />
-                          <Parameter id="clZ1aDvI2EKAPoY67KbhJA" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0487" />
-                          <Parameter id="Ce72cUd60E-_pNoRXmZA_Q" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.13" />
-                          <Parameter id="-pSmh2Mb8k2UoxFiSFQxfQ" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0163" />
-                          <Parameter id="celdHga7mkqrKSllnlG-aw" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.08" />
-                          <Parameter id="TufP_FpKDUeA2V4e91HrMg" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.158" />
-                          <Parameter id="Aqj2aW67CUu2ntnwtmTiFg" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.141" />
-                          <Parameter id="QXrZADlQTkqTlO60k54_9A" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-                          <Parameter id="OFyxtCS2_Umn0BGh3QXNBg" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.718" />
-                          <Parameter id="5kibWaTjbkC4gZbWndHVdQ" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.8" />
-                          <Parameter id="4AEqrI94TE-Vo7KYWE_YNg" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.42" />
-                          <Parameter id="aZV5OItiEEyZAAwZUC7Nxw" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0483" />
-                          <Parameter id="p76kb_UvmEyvKgUBjg-T-A" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0375" />
-                          <Parameter id="MECjoqJdo0-dhvNNlNTOlg" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0182" />
-                          <Parameter id="gJNvNvuu8kyzGQgDZ4lvog" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0124" />
-                          <Parameter id="VYNUMaaZqkSUxAylgBTN8w" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.15" />
-                          <Parameter id="jFdyBKUXNkeUtqSxXhnbCQ" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.282" />
-                          <Parameter id="J0SjK6xSFES8AC7hYdCrrg" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.456" />
-                          <Parameter id="47Vn82xZF02T3-HcMvXeQA" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.78" />
-                          <Parameter id="Y40Zdq3iRUCh_L0Bv-e8cw" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="2.41" />
-                          <Parameter id="vSpGMPyghEiDgYaXMmi1zg" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0035" />
-                          <Container id="EkzIKZP1wU2_9u7Ncqke-Q" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                            <Tags>
-                              <Tag value="Duodenum" />
-                              <Tag value="Mucosa" />
-                              <Tag value="SmallIntestineSegment" />
-                            </Tags>
-                            <Children>
-                              <Parameter id="9U8AcWfse0ybnNxvekP3yA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                              <Parameter id="6E-peO2gEE2v0y1N4CxQwQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                              <Container id="DdXkcxTIKk-j_OG04cR0fw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                                <Children>
-                                  <Parameter id="X7P5DT2w70ip-nMLeFPs_A" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" visible="0" canBeVaried="0" />
-                                  <Parameter id="OkFxsmN1LUWXpju-G5LpjQ" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                                </Children>
-                              </Container>
-                            </Children>
-                          </Container>
-                          <Container id="u4Ub16oEtECALrodgFre4w" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                            <Tags>
-                              <Tag value="Duodenum" />
-                              <Tag value="Mucosa" />
-                              <Tag value="SmallIntestineSegment" />
-                            </Tags>
-                            <Children>
-                              <Parameter id="AMbLtHwR00iEptEpsIuInw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                              <Parameter id="zzMhkh2z0kucdpHCwZO7zw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                              <Container id="frFXyiK4IESAzS-q8A4V1Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                                <Children>
-                                  <Parameter id="KdsGIvnhN0OHf2NfocPpRw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" visible="0" canBeVaried="0" />
-                                  <Parameter id="VBSo8QsRRkaxAGFilUeYeA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                                </Children>
-                              </Container>
-                            </Children>
-                          </Container>
-                          <Container id="rKg54o1HYkOhBkZfi2GWsw" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                            <Tags>
-                              <Tag value="Duodenum" />
-                              <Tag value="Mucosa" />
-                              <Tag value="SmallIntestineSegment" />
-                            </Tags>
-                            <Children>
-                              <Parameter id="5edUw5kB40yrN73BPxAs-Q" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                              <Parameter id="Jx26XBI-9kyMAO_Uyvtq-Q" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                              <Parameter id="VK0szYdQE0qYssguaq5C8w" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_pH_INT" visible="1" canBeVaried="1" />
-                              <Container id="Coc6OTfHikeT8S7_mzEPKw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                                <Children>
-                                  <Parameter id="yjThw040pEK_Zs-2kl6AIw" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                                  <Parameter id="r-gzT0IHy0WuxyAGlGkTVg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_duo" visible="0" canBeVaried="0" />
-                                </Children>
-                              </Container>
-                            </Children>
-                          </Container>
-                          <Container id="V_ZJM8cPkEqPs_Ft62p6cg" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                            <Tags>
-                              <Tag value="Duodenum" />
-                              <Tag value="IntestinalSecretionSource" />
-                              <Tag value="Mucosa" />
-                              <Tag value="SmallIntestineSegment" />
-                            </Tags>
-                            <Children>
-                              <Parameter id="4w7mEgbgvUuXqMjzE71cAQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" visible="0" canBeVaried="0" displayUnit="l" />
-                              <Parameter id="EAZgQO-9qEer8Csit-dIcw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                              <Parameter id="krpCkWgqFUGK_S5C7qAwwA" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.3" />
-                              <Container id="lLv4ovo9okiz4XTU-LDsRA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                                <Children>
-                                  <Parameter id="Jze4sNPHqEWpIAOToNE5sw" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                                  <Parameter id="_1J7o1PSR0KGYT6NHUlRpA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_duo" visible="0" canBeVaried="0" />
-                                </Children>
-                              </Container>
-                            </Children>
-                          </Container>
-                          <Container id="DA5Q8LMHPk6_4MaWnOmKqQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule" />
-                        </Children>
-                      </Container>
-                      <Container id="0vAJFGRmwkGOEsw6EaIBJA" name="UpperJejunum" description="Upper Jejunum" icon="UpperJejunum" mode="Logical" containerType="Compartment">
-                        <Children>
-                          <Parameter id="JsuZKaKkDU60Dr81he8HHQ" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="Individual_PKSim.PARAM_Tissue_Weight" visible="0" canBeVaried="1" displayUnit="kg" />
-                          <Parameter id="2Qp3GjoRoEOx_Z7IwI-xQg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="MucosaVolume.VOLUME_MucosaUpperJejunum" visible="1" canBeVaried="1" displayUnit="l" />
-                          <Parameter id="B7FUTX8WQki2zp2Osnugkw" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Q_lymph_mucosa" visible="1" canBeVaried="1" displayUnit="l/min" />
-                          <Parameter id="KpiB5VatMkSwXdhxqSRd7Q" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="VascularEndoVolume.VOLUME_VascularEndo_uje" visible="1" canBeVaried="0" displayUnit="l" />
-                          <Parameter id="Fxr_DySdVUaaTIuomeNUsg" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_J_iso_Mucosa" visible="1" canBeVaried="1" displayUnit="l/min" />
-                          <Parameter id="uguK3gC3k02O6iWfF5mfkA" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Q_mucosa" visible="1" canBeVaried="1" displayUnit="l/min" />
-                          <Parameter id="s-4OGEdwNkmqDpPSZeUXkQ" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_f_cell" visible="1" canBeVaried="1" />
-                          <Parameter id="ERBvtV-EbkmDrQtOh2E5-A" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                          <Parameter id="ZcLLl-IxRUqKHZbqB-fBuw" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                          <Parameter id="9uPOlm8FGEye1li63M1hgw" name="Fraction mucosa" description="Mucosal fraction of regional intestinal tissue mass" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.26" />
-                          <Parameter id="hkh9fyWaKkCuKomRMGZkXA" name="Fraction of regional blood flow rate" description="Regional blood flow fraction supplying the mucosal tissue of the segment" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.219" />
-                          <Parameter id="iS3GR-jkk0WfW6pEdMpaig" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" visible="1" canBeVaried="1" value="1.53888888888889E-10" displayUnit="ml/min/N" />
-                          <Parameter id="sBS0EtYx60ucSG3rp39aEw" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.05" />
-                          <Parameter id="uzSHFCBwakeHWyayy8A_RA" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="4.5E-08" displayUnit="µm" />
-                          <Parameter id="b55VCnDTDEKcoAuyK58uJw" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="2.5E-07" displayUnit="µm" />
-                          <Parameter id="BT6a4cyBR0mEBCSSJ5pJDQ" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.06" />
-                          <Parameter id="WtnegC_TSEe3H71i4b269Q" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0487" />
-                          <Parameter id="Nus8nLoenEmVIHf8P1rKJw" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.13" />
-                          <Parameter id="GXnRUyHE-UCSXvbyePargg" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.08" />
-                          <Parameter id="YCXfCDPqCUCJbXQzCZM29A" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0163" />
-                          <Parameter id="4GM1qx9cpEKYRKN8mvrxQg" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.718" />
-                          <Parameter id="7-uPyE3kP0eCtlTjIY_WLQ" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.141" />
-                          <Parameter id="zk41rN_H30aUMuHAijDUQg" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-                          <Parameter id="ZkyyGWS4SUCAO_XGVW9WZw" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.8" />
-                          <Parameter id="lP5H2R1aNU2c87l9eBMW7A" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.158" />
-                          <Parameter id="X4TS2oGyxUK5OoF7o6Lb-A" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.35" />
-                          <Parameter id="NmRM_iikHkuWaxePICzYag" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0375" />
-                          <Parameter id="zgsMJ3kqzUC_4IoLgvpLuQ" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0483" />
-                          <Parameter id="MMqAeFniokaeAheo4K72_g" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0182" />
-                          <Parameter id="sDxuqpTCck6RWOQ-QO4aXA" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0124" />
-                          <Parameter id="kpZ24QtqPEWHwABtGA5Dtw" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.15" />
-                          <Parameter id="P00bpx5fv0q0zDayDn-uZQ" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.282" />
-                          <Parameter id="f531h2E2CUa2wqdE72YXwg" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.78" />
-                          <Parameter id="RimWMdDhNEiGSDIE0gpylA" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.456" />
-                          <Parameter id="et-spFTyXEyrZr1G62VHzA" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="2.41" />
-                          <Parameter id="5EVD08-gRUG4HrSO2xwMPA" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0035" />
-                          <Container id="BfP4xKdBX0SaUMpMCDXvbg" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                            <Tags>
-                              <Tag value="Mucosa" />
-                              <Tag value="SmallIntestineSegment" />
-                              <Tag value="UpperJejunum" />
-                            </Tags>
-                            <Children>
-                              <Parameter id="gk_CboN9nEyyg2f2QtONzw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                              <Parameter id="5D0ZznAW7k23mnIZ23DViA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                              <Container id="fmPMsojYfUO8SSFCVkDWMg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                                <Children>
-                                  <Parameter id="PsTlXLLTW0aWKm9Q9joVYA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" visible="0" canBeVaried="0" />
-                                  <Parameter id="Yhxg_9rriU6HcpNKYSurXw" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                                </Children>
-                              </Container>
-                            </Children>
-                          </Container>
-                          <Container id="Ej30rRxCREi_lFbIacWhBg" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                            <Tags>
-                              <Tag value="Mucosa" />
-                              <Tag value="SmallIntestineSegment" />
-                              <Tag value="UpperJejunum" />
-                            </Tags>
-                            <Children>
-                              <Parameter id="G8A79QGSEkiRuFeX_ByQow" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                              <Parameter id="FgXSmeHeL0ON7Ujn8gkfig" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                              <Container id="KJxmenvpt0STLhV2zu97TQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                                <Children>
-                                  <Parameter id="JhF8NW4ND0-f8wwj7MnnRA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" visible="0" canBeVaried="0" />
-                                  <Parameter id="9ilEWf_xcUGHhabck1r3eg" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                                </Children>
-                              </Container>
-                            </Children>
-                          </Container>
-                          <Container id="8WvqhUtcp0qq4H3YVSDE7w" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                            <Tags>
-                              <Tag value="Mucosa" />
-                              <Tag value="SmallIntestineSegment" />
-                              <Tag value="UpperJejunum" />
-                            </Tags>
-                            <Children>
-                              <Parameter id="YYLrrbDWJU6oLnVsUU78OQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                              <Parameter id="OuD4rBK-bUWaMsq6Ju_UIQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                              <Parameter id="32Z-T_inekWLbNd_I3FBhA" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_pH_INT" visible="1" canBeVaried="1" />
-                              <Container id="DntKkG2tYUiUFhFRrCOG2A" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                                <Children>
-                                  <Parameter id="LJfff5mIIU6PgKWM9tc8Bg" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                                  <Parameter id="stu-H_I0jUuZJJ8x23lSEA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_uje" visible="0" canBeVaried="0" />
-                                </Children>
-                              </Container>
-                            </Children>
-                          </Container>
-                          <Container id="kUFeS_kjtUW66GnJH4ZzKg" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                            <Tags>
-                              <Tag value="IntestinalSecretionSource" />
-                              <Tag value="Mucosa" />
-                              <Tag value="SmallIntestineSegment" />
-                              <Tag value="UpperJejunum" />
-                            </Tags>
-                            <Children>
-                              <Parameter id="bWzWjve92U6u6AHEilVxeQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" visible="0" canBeVaried="0" displayUnit="l" />
-                              <Parameter id="8uEKa3Rjs0WHA5TYeO0Uxg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                              <Parameter id="zIOoZes37EKd0Mzu56oJDA" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.3" />
-                              <Container id="8vxlqL2WhkyE8JzkpqxS8g" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                                <Children>
-                                  <Parameter id="iftTWyocfE2xa44EHBY3lQ" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                                  <Parameter id="4O1e93bqQkq6qqQDLGJL5g" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_uje" visible="0" canBeVaried="0" />
-                                </Children>
-                              </Container>
-                            </Children>
-                          </Container>
-                          <Container id="LWdFv8tQa0-5udJdEqrA3Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule" />
-                        </Children>
-                      </Container>
-                      <Container id="1HEqWqwIcUSnaHNptxAm3A" name="LowerJejunum" description="Lower Jejunum" icon="LowerJejunum" mode="Logical" containerType="Compartment">
-                        <Children>
-                          <Parameter id="53DLJ5Ls6kSZEXYpdo2YxA" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="Individual_PKSim.PARAM_Tissue_Weight" visible="0" canBeVaried="1" displayUnit="kg" />
-                          <Parameter id="q59de6mDlk6No82LH81O0Q" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="MucosaVolume.VOLUME_MucosaLowerJejunum" visible="1" canBeVaried="1" displayUnit="l" />
-                          <Parameter id="YOJW4mCNuEm2sqnWyT0B9Q" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_J_iso_Mucosa" visible="1" canBeVaried="1" displayUnit="l/min" />
-                          <Parameter id="jtAotNt9ckG0jpKUr2CQlw" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Q_lymph_mucosa" visible="1" canBeVaried="1" displayUnit="l/min" />
-                          <Parameter id="kdy1LT8coE2bIt1_VI7Fww" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="VascularEndoVolume.VOLUME_VascularEndo_lje" visible="1" canBeVaried="0" displayUnit="l" />
-                          <Parameter id="HqCr482t8kWvsjWUs8wRBg" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Q_mucosa" visible="1" canBeVaried="1" displayUnit="l/min" />
-                          <Parameter id="BEc4gcrSx0i1NGcaT6_s2g" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_f_cell" visible="1" canBeVaried="1" />
-                          <Parameter id="FRS2bcCmM0qZzZPiufZDaQ" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                          <Parameter id="W-JiTsJZl02os9O6R-4B_g" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                          <Parameter id="AHzFVXoNrEKU_xXOMXFC1w" name="Fraction of regional blood flow rate" description="Regional blood flow fraction supplying the mucosal tissue of the segment" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.219" />
-                          <Parameter id="Kur6ujvNtkeOnd01UHpy3A" name="Fraction mucosa" description="Mucosal fraction of regional intestinal tissue mass" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.26" />
-                          <Parameter id="bW3iX_D1Vk2QDjlBGd4TIA" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="4.5E-08" displayUnit="µm" />
-                          <Parameter id="4w11HGUm4EuxXaHP9uuA5Q" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.05" />
-                          <Parameter id="ai47h2ZtY0uXHNXRPm10Uw" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" visible="1" canBeVaried="1" value="1.53888888888889E-10" displayUnit="ml/min/N" />
-                          <Parameter id="Tx8yA-yfDUK5REEiM9q_-Q" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="2.5E-07" displayUnit="µm" />
-                          <Parameter id="wfQwvIf4rkinq7B3-G_4Ug" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0487" />
-                          <Parameter id="_q3NTG7D2USJ1UEd1TO_ow" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.06" />
-                          <Parameter id="Wj6_Vid6z0CoyDz-7OwPDQ" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.13" />
-                          <Parameter id="b4GvM4CEgEm7SjNglma3gg" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0163" />
-                          <Parameter id="jTK_5lZzMUuLdDnsUkH_Hw" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.08" />
-                          <Parameter id="5o2Z4zpMqk-1zy8HGMDfDA" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.158" />
-                          <Parameter id="F__GDhv4-kCuhD8TPKHoRg" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.141" />
-                          <Parameter id="y390ccEjbkWj5G-4uQ30yg" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-                          <Parameter id="LLuJLl4pX0iGC9GltosPLQ" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.8" />
-                          <Parameter id="RjBv1hpuY0mh48xF_f95UQ" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.718" />
-                          <Parameter id="vAdOd6wY4EWVeaFYv3bklg" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.32" />
-                          <Parameter id="y-Y_tXkAZUmmH-v1C2c2Gw" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0483" />
-                          <Parameter id="3B9BDCrYwkObbLUiBJZ-FA" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0375" />
-                          <Parameter id="Q-eaQkixq0i3vDLkdKiHbg" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0182" />
-                          <Parameter id="qixQ-5M42UOOE3QdME3hQg" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0124" />
-                          <Parameter id="F2rU6OUx8ke5pTI1ubKTRA" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.282" />
-                          <Parameter id="rrvMj3Htx0ibEDJB2jR4iQ" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.15" />
-                          <Parameter id="uHZlhVZb9EO3dsdey4TiwA" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.456" />
-                          <Parameter id="eA1F4s6Htka5GLhL1mhjeQ" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.78" />
-                          <Parameter id="o4o9UgTZhUSFnO5wKfyGMQ" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0035" />
-                          <Parameter id="MSL3dqFyU0yBWfiGx6S_lA" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="2.41" />
-                          <Container id="1XxBZvONAEWWEWN1gOg4VQ" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                            <Tags>
-                              <Tag value="LowerJejunum" />
-                              <Tag value="Mucosa" />
-                              <Tag value="SmallIntestineSegment" />
-                            </Tags>
-                            <Children>
-                              <Parameter id="xZtPiQZfVUCUpBFCY6Fpmg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                              <Parameter id="diETd5_XF0-p62De1tMYyQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                              <Container id="UTuSdVQU70qrO4EbW3S95Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                                <Children>
-                                  <Parameter id="gzmNWzAY0UazClf8eeS7hw" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                                  <Parameter id="zyz3QJ6maUyOI8OV72WaOA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" visible="0" canBeVaried="0" />
-                                </Children>
-                              </Container>
-                            </Children>
-                          </Container>
-                          <Container id="JvhcU5G9sESOfI0HQ9iySg" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                            <Tags>
-                              <Tag value="LowerJejunum" />
-                              <Tag value="Mucosa" />
-                              <Tag value="SmallIntestineSegment" />
-                            </Tags>
-                            <Children>
-                              <Parameter id="AffMYD6npE6s3VjHeetFrg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                              <Parameter id="nIjeMNq73U2JG5CU8p9tvg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                              <Container id="7nsxY2Z-1USb-iQIRzN0gw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                                <Children>
-                                  <Parameter id="P3jmHKdcA0mVtbxkcpHb9w" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                                  <Parameter id="tGk9aX33eUaUG13J-N6EJg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" visible="0" canBeVaried="0" />
-                                </Children>
-                              </Container>
-                            </Children>
-                          </Container>
-                          <Container id="honL0CTkBUiLa6hPDJjRow" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                            <Tags>
-                              <Tag value="LowerJejunum" />
-                              <Tag value="Mucosa" />
-                              <Tag value="SmallIntestineSegment" />
-                            </Tags>
-                            <Children>
-                              <Parameter id="vz9H4G8hSUKxBoxitm6J1g" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                              <Parameter id="Yad7tMmcakKayXpPk484zg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                              <Parameter id="PRH8HDULPkGR2X34h0dV9g" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_pH_INT" visible="1" canBeVaried="1" />
-                              <Container id="fAXzSc59r02-swH03Qja3Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                                <Children>
-                                  <Parameter id="-5BrZweOtU-gtFBpr6wXrA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_lje" visible="0" canBeVaried="0" />
-                                  <Parameter id="ayS3xAMDIUSEa2bhGH0Vcg" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                                </Children>
-                              </Container>
-                            </Children>
-                          </Container>
-                          <Container id="H45QSpDHZU6_rrF8B6S3IQ" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                            <Tags>
-                              <Tag value="IntestinalSecretionSource" />
-                              <Tag value="LowerJejunum" />
-                              <Tag value="Mucosa" />
-                              <Tag value="SmallIntestineSegment" />
-                            </Tags>
-                            <Children>
-                              <Parameter id="IP5nPiFI1EmfeWfp0SXrcg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" visible="0" canBeVaried="0" displayUnit="l" />
-                              <Parameter id="wIe9plonnki8OcH0EBnV0w" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                              <Parameter id="AsZKmN4fTkKKz06NgU2GqQ" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.3" />
-                              <Container id="BDFqk2qcwEurRHry2Uc7CQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                                <Children>
-                                  <Parameter id="XHqKAS83f0GVpyKfGdk3xg" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                                  <Parameter id="E2C2MDQf3USagG2zCCpO1w" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_lje" visible="0" canBeVaried="0" />
-                                </Children>
-                              </Container>
-                            </Children>
-                          </Container>
-                          <Container id="JTPLA49GwUmoZRjD142Aqw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule" />
-                        </Children>
-                      </Container>
-                      <Container id="fyOwEYedkEeFH8S2n_n5hw" name="UpperIleum" description="Upper Ileum" icon="UpperIleum" mode="Logical" containerType="Compartment">
-                        <Children>
-                          <Parameter id="Ys7JrxXcLEWqsYJ3VYshng" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="Individual_PKSim.PARAM_Tissue_Weight" visible="0" canBeVaried="1" displayUnit="kg" />
-                          <Parameter id="7MviCuES8ESSYeIQaEtwvQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="MucosaVolume.VOLUME_MucosaUpperIleum" visible="1" canBeVaried="1" displayUnit="l" />
-                          <Parameter id="St8Fn15DJUClDcxA4ai6Fg" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_J_iso_Mucosa" visible="1" canBeVaried="1" displayUnit="l/min" />
-                          <Parameter id="0XPh23om3E2k58i9rOjRQg" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Q_lymph_mucosa" visible="1" canBeVaried="1" displayUnit="l/min" />
-                          <Parameter id="HoO4deZ1U0K2enuI-IizdQ" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="VascularEndoVolume.VOLUME_VascularEndo_uil" visible="1" canBeVaried="0" displayUnit="l" />
-                          <Parameter id="p-9qxigADU6C35Uq-2ngxQ" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Q_mucosa" visible="1" canBeVaried="1" displayUnit="l/min" />
-                          <Parameter id="djrZwbH-xEGXJqqSEhcOQw" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_f_cell" visible="1" canBeVaried="1" />
-                          <Parameter id="liZCvWoCIkeqc7XwQYHpqw" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                          <Parameter id="ImUsLbCPQUOKSLvZRvE-Mg" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                          <Parameter id="ODshviadd06syxwFYGEeEw" name="Fraction mucosa" description="Mucosal fraction of regional intestinal tissue mass" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.13" />
-                          <Parameter id="fLZiCZ_fl0Sol5UOnt-jGw" name="Fraction of regional blood flow rate" description="Regional blood flow fraction supplying the mucosal tissue of the segment" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.2345" />
-                          <Parameter id="MrR8QlWN00O6dW_BxZRD0g" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="2.5E-07" displayUnit="µm" />
-                          <Parameter id="JiDwIizDy0Wo0EhBg8joAg" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" visible="1" canBeVaried="1" value="1.53888888888889E-10" displayUnit="ml/min/N" />
-                          <Parameter id="4kNaspC7t0OoynSbCNgDPg" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.05" />
-                          <Parameter id="ikbFXSss3kOzI7I4Esmztw" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="4.5E-08" displayUnit="µm" />
-                          <Parameter id="IyeJkm2sqU-C9F7UuOEupw" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.06" />
-                          <Parameter id="ZrCLYo2xVE2YFHYvPkpSzQ" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0487" />
-                          <Parameter id="rEAwBpWYckyf891_HzDTBw" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.13" />
-                          <Parameter id="sDzWBZ7qekubaSfgV10csw" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.08" />
-                          <Parameter id="Ea8WUt4ckkyg1kgvzOzl7g" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0163" />
-                          <Parameter id="kyLZtovvwUuKwn6U8UdsAQ" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.8" />
-                          <Parameter id="v6o_hyuXPEKKhiN7AgD8rA" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.158" />
-                          <Parameter id="VJPUnZF67EGJPc7LFxuKSA" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.141" />
-                          <Parameter id="SlBrQcobVE6gIgnrXuZBcQ" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-                          <Parameter id="t5vt_B-SW0i6CBwsF4n4oQ" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.718" />
-                          <Parameter id="Awu-cBPQe0uqiRsDs5ODLQ" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.31" />
-                          <Parameter id="tH-erxKiK0m8hMNeQWxdjQ" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0483" />
-                          <Parameter id="AgLHEgDY9U6kIfDkVamTIg" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0375" />
-                          <Parameter id="4aPlxuSQEEGVFx9G38tdDw" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0124" />
-                          <Parameter id="zAx2igbYHUGS72Pdoxss_A" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0182" />
-                          <Parameter id="ubFuwpzgjkGEUe-zXP_i0A" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.282" />
-                          <Parameter id="_wICt8FZ80WDAKeumXRBoA" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.15" />
-                          <Parameter id="Qsu9I5Py5ECzzJpOhkO3Xw" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.78" />
-                          <Parameter id="-BhaNu6Qa0u_umiNePh42g" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.456" />
-                          <Parameter id="AMOhlCSVLU-8ccAZxehWgA" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0035" />
-                          <Parameter id="1W2FQmzRhEasGUqYudjHHQ" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="2.41" />
-                          <Container id="agEz-d8UnU2AlENh6qiY5A" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                            <Tags>
-                              <Tag value="Mucosa" />
-                              <Tag value="SmallIntestineSegment" />
-                              <Tag value="UpperIleum" />
-                            </Tags>
-                            <Children>
-                              <Parameter id="S9jVyWPqgE6xikF3csBKzg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                              <Parameter id="MeKof2Nh1EuxVVmc4QTohA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                              <Container id="O0JsKRUbGEed__yXClIMow" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                                <Children>
-                                  <Parameter id="PVYMfJEaJEaPpdNl0mgyfw" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                                  <Parameter id="7nE5tnsiWEuDrcmGwVDIPw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" visible="0" canBeVaried="0" />
-                                </Children>
-                              </Container>
-                            </Children>
-                          </Container>
-                          <Container id="o2sI8fS0SkSgY4brbhcmyA" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                            <Tags>
-                              <Tag value="Mucosa" />
-                              <Tag value="SmallIntestineSegment" />
-                              <Tag value="UpperIleum" />
-                            </Tags>
-                            <Children>
-                              <Parameter id="c6St3lUDlkq-55Fg3g0MVw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                              <Parameter id="xM9LGc2CbkaV2nr6JiBbBw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                              <Container id="5lEcsnXyZUyMkgoWQBQXvg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                                <Children>
-                                  <Parameter id="60HlMeETh0yErFbLVVgYHg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" visible="0" canBeVaried="0" />
-                                  <Parameter id="DsttZgjI2kqjObALs3IgsA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                                </Children>
-                              </Container>
-                            </Children>
-                          </Container>
-                          <Container id="VS_6r7J0k0WDnZVbs6ZemQ" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                            <Tags>
-                              <Tag value="Mucosa" />
-                              <Tag value="SmallIntestineSegment" />
-                              <Tag value="UpperIleum" />
-                            </Tags>
-                            <Children>
-                              <Parameter id="JLNkKgHnykOUP8a1sV1r8w" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                              <Parameter id="1rr3gLhsGEaC40CNfKJNbA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                              <Parameter id="Ets-HFNFkkqX69xHW8hTNA" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_pH_INT" visible="1" canBeVaried="1" />
-                              <Container id="MyZIqSsuoUuxtbwFux_uNQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                                <Children>
-                                  <Parameter id="e7pXpQbKcUmkQ65FQRxsQQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_uil" visible="0" canBeVaried="0" />
-                                  <Parameter id="kFzqbMY9yUS4kHCNzRcLuA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                                </Children>
-                              </Container>
-                            </Children>
-                          </Container>
-                          <Container id="Ei9kUV8Ht0yP_sgNxLtolg" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                            <Tags>
-                              <Tag value="IntestinalSecretionSource" />
-                              <Tag value="Mucosa" />
-                              <Tag value="SmallIntestineSegment" />
-                              <Tag value="UpperIleum" />
-                            </Tags>
-                            <Children>
-                              <Parameter id="rQlWILmi6kOcMrUFzP6bRQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" visible="0" canBeVaried="0" displayUnit="l" />
-                              <Parameter id="k5L0Gp-OXUSIoifoJiHf-Q" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                              <Parameter id="GhhSudIik0e5RcrIv3teAA" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.3" />
-                              <Container id="S2sd5ldlQEG_BfFtdChJBg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                                <Children>
-                                  <Parameter id="nJNmVMrLLUuD1NO4gyFNJQ" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                                  <Parameter id="zWqLrwDNAkCqFEJR7TR3gA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_uil" visible="0" canBeVaried="0" />
-                                </Children>
-                              </Container>
-                            </Children>
-                          </Container>
-                          <Container id="-NIoVUlb606UB9rDwho6_w" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule" />
-                        </Children>
-                      </Container>
-                      <Container id="8nkimGq9FUmePzFz6Bfyjg" name="LowerIleum" description="Lower Ileum" icon="LowerIleum" mode="Logical" containerType="Compartment">
-                        <Children>
-                          <Parameter id="NorT6rowpUWB_nh2Tgl5xg" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="Individual_PKSim.PARAM_Tissue_Weight" visible="0" canBeVaried="1" displayUnit="kg" />
-                          <Parameter id="TcEgIeMpjkWZMB6ymRbaRA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="MucosaVolume.VOLUME_MucosaLowerIleum" visible="1" canBeVaried="1" displayUnit="l" />
-                          <Parameter id="57uuvIfetkGV2P9ja37jgA" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="VascularEndoVolume.VOLUME_VascularEndo_lil" visible="1" canBeVaried="0" displayUnit="l" />
-                          <Parameter id="A0fIxG1UpkeZrLbRzn7tbg" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Q_lymph_mucosa" visible="1" canBeVaried="1" displayUnit="l/min" />
-                          <Parameter id="s5LgHXHewUWcBWJaMsYBLg" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_J_iso_Mucosa" visible="1" canBeVaried="1" displayUnit="l/min" />
-                          <Parameter id="21tthNZtlE-GQFfG6m9SQw" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Q_mucosa" visible="1" canBeVaried="1" displayUnit="l/min" />
-                          <Parameter id="t-BcGFWcPkiDgPgSAtQU8w" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_f_cell" visible="1" canBeVaried="1" />
-                          <Parameter id="YJ8xXI4DvUedDTWkV9ngDA" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                          <Parameter id="n82TfxbuAk2zf2vETDLjBg" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                          <Parameter id="CnXi-VGXeEGD8otbxXaT-Q" name="Fraction mucosa" description="Mucosal fraction of regional intestinal tissue mass" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.13" />
-                          <Parameter id="A4PV2CU7H02Mh9Xi5HjNuA" name="Fraction of regional blood flow rate" description="Regional blood flow fraction supplying the mucosal tissue of the segment" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.2345" />
-                          <Parameter id="PQQAp9ZarE6kzAf9U7SH_w" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.05" />
-                          <Parameter id="XZhrsm1l_067P9uwXiWyHg" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="4.5E-08" displayUnit="µm" />
-                          <Parameter id="0khUddi0Xkm1InBNswFV5A" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" visible="1" canBeVaried="1" value="1.53888888888889E-10" displayUnit="ml/min/N" />
-                          <Parameter id="84rpml3AX0ynZr_997Ut5A" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="2.5E-07" displayUnit="µm" />
-                          <Parameter id="-6x6PcnMdE-YX_9KfLe3gA" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0487" />
-                          <Parameter id="yLmZVVROokWjAKnIVqKHVA" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.06" />
-                          <Parameter id="cOrDiGxoeUyqCl30EKYarQ" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.13" />
-                          <Parameter id="bb5oYubHYU2tXKHtWDCf4A" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0163" />
-                          <Parameter id="995hwoCQE0q_HVvBuuI2zg" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.08" />
-                          <Parameter id="mee-XJjYp0i_ZJfE_rGUhA" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.158" />
-                          <Parameter id="e3wp5CdhDEmofnN4Hji8GQ" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.141" />
-                          <Parameter id="x9VHgmod-kao4hoEwF5cGw" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-                          <Parameter id="slor9T3W_Ey14oj5Wc_NRA" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.718" />
-                          <Parameter id="tgg9cnGG_EqAZvTaXC8Scg" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.8" />
-                          <Parameter id="VJ6vS_qpskWAbb1K2VHxDw" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.32" />
-                          <Parameter id="8ll_dWUJr0Or4XQPEb5xAw" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0483" />
-                          <Parameter id="MriOIBP2HE2uW22whbFAEQ" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0375" />
-                          <Parameter id="wa0aFlTMAEOb3QDt_00oRw" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0124" />
-                          <Parameter id="-oB07_H0DkePVZ0AUAgCJA" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0182" />
-                          <Parameter id="5OTWlT_HvU-qkz1uuHO8ZA" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.15" />
-                          <Parameter id="TyAFrcbCY02Aiz_IJ70Alw" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.282" />
-                          <Parameter id="CsnjmQdUgEOpX0muxVcWxQ" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.456" />
-                          <Parameter id="qOeU5aiiZUOVJlzDotL3yg" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.78" />
-                          <Parameter id="GDcAK3XBREaeQX7fzHxSxA" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0035" />
-                          <Parameter id="Grj6i3A8L0SwgDkX2z78gA" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="2.41" />
-                          <Container id="SheBaQRntUS7Uq436niclQ" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                            <Tags>
-                              <Tag value="LowerIleum" />
-                              <Tag value="Mucosa" />
-                              <Tag value="SmallIntestineSegment" />
-                            </Tags>
-                            <Children>
-                              <Parameter id="k4hc1Q4q6UuNlOUkjyfvUA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                              <Parameter id="umJGb6OZg0eqa5-hsI-Z5A" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                              <Container id="5ds58e1SuEqQh5nO5r39zw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                                <Children>
-                                  <Parameter id="Q9ONGw3hykaRAb4zbDm5Ig" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                                  <Parameter id="w0nRNt3unkyquv5Tn9nrdQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" visible="0" canBeVaried="0" />
-                                </Children>
-                              </Container>
-                            </Children>
-                          </Container>
-                          <Container id="ziNIenMYrkK_Eu94Cg5BFQ" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                            <Tags>
-                              <Tag value="LowerIleum" />
-                              <Tag value="Mucosa" />
-                              <Tag value="SmallIntestineSegment" />
-                            </Tags>
-                            <Children>
-                              <Parameter id="jArPjWoRrk2kAcFOedPovw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                              <Parameter id="QYKzUwMqak2vILugN7wPPQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                              <Container id="zBhzRx1rdEmozr4ZnnNI3Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                                <Children>
-                                  <Parameter id="sEqauZxTb0SiDLPKa8OZlQ" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                                  <Parameter id="CxUhPcqLG0C40tBMGJbDAg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" visible="0" canBeVaried="0" />
-                                </Children>
-                              </Container>
-                            </Children>
-                          </Container>
-                          <Container id="lsB27MsEJE2VZfZQB7uX0Q" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                            <Tags>
-                              <Tag value="LowerIleum" />
-                              <Tag value="Mucosa" />
-                              <Tag value="SmallIntestineSegment" />
-                            </Tags>
-                            <Children>
-                              <Parameter id="oa4RxVg9cU2jYdc1Y0b8iw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                              <Parameter id="mQ_0whfa9UWM5H4rchf-Kg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                              <Parameter id="IeM_E2O0iE2EK-CaHYauDw" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_pH_INT" visible="1" canBeVaried="1" />
-                              <Container id="heL8RP9RJEmQkx4hPOHkMA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                                <Children>
-                                  <Parameter id="0QelH9AekUqJV_GAbOa4jA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                                  <Parameter id="qFyPM5MkZ02n5r4PmCB1qQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_lil" visible="0" canBeVaried="0" />
-                                </Children>
-                              </Container>
-                            </Children>
-                          </Container>
-                          <Container id="an9mtKGGd0m69RC9jFTrLA" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                            <Tags>
-                              <Tag value="IntestinalSecretionSource" />
-                              <Tag value="LowerIleum" />
-                              <Tag value="Mucosa" />
-                              <Tag value="SmallIntestineSegment" />
-                            </Tags>
-                            <Children>
-                              <Parameter id="Cr2x9hSDL0u6r1wB1o7-Xg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" visible="0" canBeVaried="0" displayUnit="l" />
-                              <Parameter id="RYw2TJCgNU2R7lFaIpPE_g" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                              <Parameter id="k9qe6Md3vEWkDfg0l_pz0g" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.3" />
-                              <Container id="6NyPjJIYK0qDksHCB2Ulqw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                                <Children>
-                                  <Parameter id="-RTUX3rgxU2P6FIUionfJA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                                  <Parameter id="tZZSVy55akKzwLNYG1E7Cw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_lil" visible="0" canBeVaried="0" />
-                                </Children>
-                              </Container>
-                            </Children>
-                          </Container>
-                          <Container id="lFFMwtt3bUyue0MxbUlyzg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule" />
-                        </Children>
-                      </Container>
-                    </Children>
-                  </Container>
-                </Children>
-              </Container>
-              <Container id="mS4jII2PikeoGXb-dohEjw" name="LargeIntestine" description="LargeIntestine" icon="LargeIntestine" mode="Logical" containerType="Organ">
-                <Tags>
-                  <Tag value="Portal Vein Supplying Organ" />
-                  <Tag value="TissueOrgan" />
-                </Tags>
-                <Children>
-                  <Parameter id="98w9G6qoM0id6wscEo2xtg" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="Individual_PKSim.PARAM_Tissue_Weight" visible="0" canBeVaried="1" displayUnit="kg" />
-                  <Parameter id="O548iR4Fg0u8g0u4J4JNkw" name="Volume (mucosa)" description="Volume of mucosa" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="MucosaVolume.VOLUME_LargeIntestineMucosa" visible="1" canBeVaried="1" displayUnit="l" />
-                  <Parameter id="5JGsH90Ff0yWQpPOdjAhnQ" name="Large intestinal transit time factor" description="Large intestinal transit time factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Lumen_PKSim.PARAM_LITT_Factor" visible="0" canBeVaried="1" />
-                  <Parameter id="MYd4CIYgdkCrWequFF_Rhg" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_FluidRecirculationRate_lin" visible="1" canBeVaried="0" displayUnit="l/min" />
-                  <Parameter id="n2eRYHUpt0m7kPYKoUc7dg" name="Fluid recirculation flow rate (incl. mucosa)" description="Fluid recirculation flow rate between plasma and interstitial space (incl. mucosa)" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate_(incl._mucosa)_LargeIntestine" visible="1" canBeVaried="1" displayUnit="l/min" />
-                  <Parameter id="EERu2Ukks0yI_jpsFx-ltw" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Q_Lymph_lin" visible="1" canBeVaried="0" displayUnit="l/min" />
-                  <Parameter id="rvfmaI20bUSOfpR71gUE2w" name="Lymph flow rate (incl. mucosa)" description="Lymph flow rate (incl. mucosa)" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Lymph_flow_rate_(incl._mucosa)_LargeIntestine" visible="1" canBeVaried="1" displayUnit="l/min" />
-                  <Parameter id="Osdxoz11AEG5zC4zscHmnQ" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="VascularEndoVolume.VOLUME_VascularEndo_lin" visible="1" canBeVaried="0" displayUnit="l" />
-                  <Parameter id="lOUkcv9CvkKFtPCY6Gvg8w" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_f_cell" visible="1" canBeVaried="1" />
-                  <Parameter id="zSGuNQa1BkG3Q6mzTvgNzQ" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Q_from_Qspec" visible="1" canBeVaried="1" displayUnit="l/min" />
-                  <Parameter id="AJhsSPgIPkylkf8lJHb0qw" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                  <Parameter id="Bv8h1UJiqEiv00Xh0HtwZA" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.75" />
-                  <Parameter id="30RvddI3Pka5pBSLPkfWJw" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                  <Parameter id="FcwnMXsxTE6PD3HIfdMlJw" name="Mucosa blood flow fraction" description="Blood fraction which goes to mucosa" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.75" />
-                  <Parameter id="YxoAxLHngU6G4bsIaOz_gw" name="Large intestinal transit time factor slope" description="Large intestinal transit time factor slope" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" visible="0" canBeVaried="0" value="0.938" displayUnit="1/min" />
-                  <Parameter id="MO_FcnN_u0imK4ymreulhA" name="Large intestinal transit time factor intercept" description="Large intestinal transit time factor intercept" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="0" value="47.6" />
-                  <Parameter id="R_HodPT5Nkitzhvc6RyN_g" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="4.5E-08" displayUnit="µm" />
-                  <Parameter id="GwAtHWBPykuj-KiqNnJTFQ" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="2.5E-07" displayUnit="µm" />
-                  <Parameter id="Zlxwzz5S7EmdIfWpcFvASQ" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.05" />
-                  <Parameter id="mxuY09HQaki6L-TD0qpuaw" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" visible="1" canBeVaried="1" value="1.86944444444444E-10" displayUnit="ml/min/N" />
-                  <Parameter id="6fbl__y8C0WIyHfR9OYnPg" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.062" />
-                  <Parameter id="0Y4MnJt9d0W8ZsflRnDiAw" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0487" />
-                  <Parameter id="eW7bruglikOF0IojV2mGiA" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.024" />
-                  <Parameter id="JvCNZ5ycAEeDxZJotMzcOw" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.133" />
-                  <Parameter id="Gzt0d1y1IkKzzzRzWr1AdQ" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0163" />
-                  <Parameter id="Llz-CcjHr0uLAVm_PvPMqw" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.141" />
-                  <Parameter id="HHLvIR88TkGeHg85qbEKCQ" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.718" />
-                  <Parameter id="61eFmX-BbE6F9Dl7c2Q92w" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.792" />
-                  <Parameter id="FGbVx5fMHkSpRLGKOiDkFA" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.158" />
-                  <Parameter id="KmGKcVOSrECMGtq5ldeZFw" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-                  <Parameter id="4-RLuxZU6EikMOkaF6lz6Q" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.094" />
-                  <Parameter id="1fcT9tnTbUuoi089Y8Iu-w" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0483" />
-                  <Parameter id="qTM5ODDdeUaKtXHJAQiv3w" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0375" />
-                  <Parameter id="oskOzGCeNEOb0I-A_mZQsQ" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0182" />
-                  <Parameter id="JOTbmc_MzEaXF8zvHEqqyA" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0124" />
-                  <Parameter id="SRR2FnMp9Uuox3VFhsEW7A" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.282" />
-                  <Parameter id="pb1txZyZtkuI5muNlh110Q" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.15" />
-                  <Parameter id="H5uiK1qOLE2FdImghOap8w" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.456" />
-                  <Parameter id="YNPysvYOU0W5wbYQxm9SCA" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.78" />
-                  <Parameter id="uW83vPCDXU6yQRIvx-31QQ" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="2.41" />
-                  <Parameter id="c1nG7n1SgUipZwzXCqAqxg" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0035" />
-                  <DistributedParameter id="z9lSF81FOUak6X5ykYn_Sg" name="Large intestinal transit time" description="The time required for the passage of a non-absorbable compound through the large intestine, defined as the time span between small intestinal transit (i.e. the point at which 90% of the drug mass has entered the caecum) and the time at which 70% is excreted into feces" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" formula="XD1C9LNZb0CvdfAlYarLYg" mode="Logical" visible="1" displayUnit="h">
-                    <Children>
-                      <Parameter id="9F0p0R5C8E21VbwxfRyonA" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" displayUnit="h" />
-                      <Parameter id="XxculACkEUG_Jc7f_SrbFg" name="Mean" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" visible="0" canBeVaried="1" value="2652" displayUnit="h" />
-                    </Children>
-                  </DistributedParameter>
-                  <DistributedParameter id="ilqP_wnnTkm9gKF4hYS3yg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="gX4XIQRAAE2eyN4lSRnq6Q" mode="Logical" visible="1" displayUnit="l">
-                    <Children>
-                      <Parameter id="Os1RDzXuMESciB6W92Jyfw" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.501896001506457" displayUnit="l" />
-                      <Parameter id="MVzT4-OanUehmCRH_BT24g" name="Mean" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" value="0.332056702440576" displayUnit="l" />
-                      <Parameter id="tKYs6wwQSkCAvKq1bR_qEw" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0649145074993143" displayUnit="l" />
-                    </Children>
-                  </DistributedParameter>
-                  <DistributedParameter id="yjixy6mOVkeLUPSC2XaaVw" name="Specific blood flow rate" description="Blood flow rate normalized to the organ volume" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" formula="z5l3SmEWzEyPYdw7almqCA" mode="Logical" visible="1" displayUnit="ml/min/100g organ">
-                    <Children>
-                      <Parameter id="vX79kZXF-UScEVAiBvgTQw" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" displayUnit="ml/min/100g organ" />
-                      <Parameter id="9tvyAqb-4kOPI0MY8owfZQ" name="Mean" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" visible="0" canBeVaried="1" value="0.6305" displayUnit="ml/min/100g organ" />
-                      <Parameter id="UJTtsQZlME6n1heIHVXfFw" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" visible="0" canBeVaried="1" value="0.031525" displayUnit="ml/min/100g organ" />
-                    </Children>
-                  </DistributedParameter>
-                  <Container id="pX3ccCxXKEyKOoR4QI5kRg" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="LargeIntestine" />
-                      <Tag value="Portal Vein Supplying Organ" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="0MwhLKZzhUC2z7ocAe-GuQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="KOQ8qC1EKkixEsjLvLv1gw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_pls_SinLin" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Container id="iEl240_g70m7UirbI_SmMA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                        <Children>
-                          <Parameter id="kZKS3eJ0Ekqc7gr8OabRgA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" visible="0" canBeVaried="0" />
-                          <Parameter id="LxavEh2rmku7uarWM9jfHg" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                        </Children>
-                      </Container>
-                    </Children>
-                  </Container>
-                  <Container id="PHp1m9J9BUW9Wt4S_ZSJwQ" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="LargeIntestine" />
-                      <Tag value="Portal Vein Supplying Organ" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="jMbAso9x2Ee9Euh1M5t6iA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="mEBSTHVEv0eyhvq4t5H3bA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_bc_SinLin" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Container id="mDY5EWDkpUK4gikejvimKQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                        <Children>
-                          <Parameter id="6ho6jsSKIUOuGC5K0KWaTA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                          <Parameter id="wTD3p13Le0OqaNverE7VGw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" visible="0" canBeVaried="0" />
-                        </Children>
-                      </Container>
-                    </Children>
-                  </Container>
-                  <Container id="0OwBcRx450qQxH3cgG_UQg" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="LargeIntestine" />
-                      <Tag value="Portal Vein Supplying Organ" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="h_bezEI7TE2RYc_DfZXaxw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="nTHMrM7GUkWb4UkmhWXFlw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_int_SinLin" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Parameter id="NvjGAiQmFEqxY6fjj7CubA" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_pH_INT" visible="1" canBeVaried="1" />
-                      <Container id="iatv-Aoun0GPD5vYFADxmQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                        <Children>
-                          <Parameter id="egcYq8IUWEepIfIaYGWl0A" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                          <Parameter id="ui5XvT54IUargG_YFpMWrQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_lin" visible="0" canBeVaried="0" />
-                        </Children>
-                      </Container>
-                    </Children>
-                  </Container>
-                  <Container id="SsjWITg_cki0-Sl5N7Etww" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="LargeIntestine" />
-                      <Tag value="Portal Vein Supplying Organ" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="uHJl1ItlQEKiNo1suvRFSw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ_SinLin" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="e2199hclGUu3oVS4SDGiDQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_cell_SinLin" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Parameter id="KjNYpdM_Hke7G5ZnxELGVQ" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.4" />
-                      <Container id="rtDpXb1MD0W1ZbTR9UjxHw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                        <Children>
-                          <Parameter id="rW71qmeJskuUp_8fC_G7HQ" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                          <Parameter id="rKAQIoAfxk-9iHjnRFcQ5w" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_lin" visible="0" canBeVaried="0" />
-                        </Children>
-                      </Container>
-                    </Children>
-                  </Container>
-                  <Container id="-Jv3PilFfEWy3Hjs3zu2EA" name="Mucosa" description="Mucosa" mode="Logical" containerType="Compartment">
-                    <Children>
-                      <Container id="0GK2BGRdNEOoZ697IgWg6w" name="Caecum" description="Cecum" icon="Caecum" mode="Logical" containerType="Compartment">
-                        <Children>
-                          <Parameter id="2CeoFt1HhEeoiUVKjDlOGw" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="Individual_PKSim.PARAM_Tissue_Weight" visible="0" canBeVaried="1" displayUnit="kg" />
-                          <Parameter id="lmmi4Nf5Ak6nnQlPueTd0g" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="MucosaVolume.VOLUME_MucosaCaecum" visible="1" canBeVaried="1" displayUnit="l" />
-                          <Parameter id="5bdzs1vNtEeF0ynLUP5utw" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="VascularEndoVolume.VOLUME_VascularEndo_cae" visible="1" canBeVaried="0" displayUnit="l" />
-                          <Parameter id="47MZpKpET0qRHYbIYsQSLQ" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_J_iso_Mucosa" visible="1" canBeVaried="1" displayUnit="l/min" />
-                          <Parameter id="SFYMNIV8vE6WXZMcVunoDw" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Q_lymph_mucosa" visible="1" canBeVaried="1" displayUnit="l/min" />
-                          <Parameter id="BR26U2Kwe0m-EknTgWONjg" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Q_mucosa" visible="1" canBeVaried="1" displayUnit="l/min" />
-                          <Parameter id="C0782oAvcUG2nhS3wYWdyQ" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_f_cell" visible="1" canBeVaried="1" />
-                          <Parameter id="4bIxpKqdjkaY8zsdX8t_RQ" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                          <Parameter id="JWIi24ABJUCTnP-X1G6vHQ" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                          <Parameter id="7tmjF5NTXE6UzkMGZUApsw" name="Fraction of regional blood flow rate" description="Regional blood flow fraction supplying the mucosal tissue of the segment" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.084706" />
-                          <Parameter id="IcQ-ZiksJ0yepo-sjaCNIQ" name="Fraction mucosa" description="Mucosal fraction of regional intestinal tissue mass" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.19" />
-                          <Parameter id="UZyGN7sZa0yzjKmhxJtnNw" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="4.5E-08" displayUnit="µm" />
-                          <Parameter id="I-nAKjZChE2_kooJ5usRHw" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.05" />
-                          <Parameter id="OhT8iZzBK0ecreu1-dPVYA" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="2.5E-07" displayUnit="µm" />
-                          <Parameter id="dfIer4FLqEGxheTqmg24gQ" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" visible="1" canBeVaried="1" value="1.86944444444444E-10" displayUnit="ml/min/N" />
-                          <Parameter id="1aTuJNj-9kaeUNCSPznQSg" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0487" />
-                          <Parameter id="BKhtmcHtFEyLFNcGEo4EWg" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.06" />
-                          <Parameter id="cV1LKJMylUS1g2gORRApng" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.13" />
-                          <Parameter id="maOGzU8zZUiysBKhi0HfyQ" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.08" />
-                          <Parameter id="xraWmJnwwEmtJtOIlBLnuA" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0163" />
-                          <Parameter id="8LqK_ePTXEO8egvlGShWOg" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.718" />
-                          <Parameter id="7Gs3zea45k6gtyk4gzjy4Q" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.141" />
-                          <Parameter id="BmFPpdN6SkirVHc73A0BWg" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.8" />
-                          <Parameter id="k4dI4ey-G0eUfFNuWDX4Pg" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.158" />
-                          <Parameter id="h_DN9rLT0kiGwoBAaMebSA" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-                          <Parameter id="VwOT9eDvQ02wj0VZg6LneQ" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.73" />
-                          <Parameter id="W_qtV6botk20-LDCJxttgg" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0483" />
-                          <Parameter id="c7LBq8v7WEqBLztnlBmK4A" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0375" />
-                          <Parameter id="dhTrIVfwbUyZQZVwFzBrsA" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0124" />
-                          <Parameter id="-dEpLQHuDki46Y-Qe8VeJg" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0182" />
-                          <Parameter id="cR3yslGTz0uvd2SnHV0nbw" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.282" />
-                          <Parameter id="AaGPz0ItC0qmGPER82p7Tw" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.15" />
-                          <Parameter id="kKXsa5uelEW8Nb3niwS7eA" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.456" />
-                          <Parameter id="k8fPr5NAz0-aX-M3xVHnZw" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.78" />
-                          <Parameter id="5o3y8BSI6EqtqFxv_p9FqQ" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0035" />
-                          <Parameter id="yRwZxhgs_kuKoTIsaUcRXw" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="2.41" />
-                          <Container id="LGbzLR1sNEiVJUOKeIrgIw" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                            <Tags>
-                              <Tag value="Caecum" />
-                              <Tag value="LargeIntestineSegment" />
-                              <Tag value="Mucosa" />
-                            </Tags>
-                            <Children>
-                              <Parameter id="EITMXmZhFkOsqT6o_N2P7g" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                              <Parameter id="vmteF8AZJ0SnRl6UPM8ALA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                              <Container id="aO8OrFGNbEyoxE9uvZJwaQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                                <Children>
-                                  <Parameter id="M3_x6VWK30qauvwn8ASVpA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                                  <Parameter id="EgPq10wu70qRM0pq8RVuBg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" visible="0" canBeVaried="0" />
-                                </Children>
-                              </Container>
-                            </Children>
-                          </Container>
-                          <Container id="aBn4kASOREa7YsOFIEj5NA" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                            <Tags>
-                              <Tag value="Caecum" />
-                              <Tag value="LargeIntestineSegment" />
-                              <Tag value="Mucosa" />
-                            </Tags>
-                            <Children>
-                              <Parameter id="16KaaLQwp0-hH-L5CCPxlA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                              <Parameter id="DWBhMlPD_0etLG48DVoKlQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                              <Container id="mMcYGFeRGU2ZN4l7m5Ns9w" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                                <Children>
-                                  <Parameter id="fFMCYdgZeU-zvss8ITvdoA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                                  <Parameter id="m-ldURgK-0GFyH0Nyray4Q" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" visible="0" canBeVaried="0" />
-                                </Children>
-                              </Container>
-                            </Children>
-                          </Container>
-                          <Container id="8TogfNoTa0-5OdFn8m3ejg" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                            <Tags>
-                              <Tag value="Caecum" />
-                              <Tag value="LargeIntestineSegment" />
-                              <Tag value="Mucosa" />
-                            </Tags>
-                            <Children>
-                              <Parameter id="-HgJQH91506eL3e1UbuIUQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                              <Parameter id="qCxUraitY06r2RRmJBwAtg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                              <Parameter id="dqUqRLKiWE2b50ygTzV9UA" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_pH_INT" visible="1" canBeVaried="1" />
-                              <Container id="GpH6I4cfPUa8OF_IQYOAFw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                                <Children>
-                                  <Parameter id="9jNmsJu3fEOZPzY-J1cg3g" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                                  <Parameter id="4FFU2QRlckCiwHxwSBAfeg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_cae" visible="0" canBeVaried="0" />
-                                </Children>
-                              </Container>
-                            </Children>
-                          </Container>
-                          <Container id="Joj-umseKkiu2xQHcZDCWA" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                            <Tags>
-                              <Tag value="Caecum" />
-                              <Tag value="IntestinalSecretionSource" />
-                              <Tag value="LargeIntestineSegment" />
-                              <Tag value="Mucosa" />
-                            </Tags>
-                            <Children>
-                              <Parameter id="BVcZAgUWnEm5vk3xPtweXA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" visible="0" canBeVaried="0" displayUnit="l" />
-                              <Parameter id="9aOzDGiBPk6tqI30UzBB1A" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                              <Parameter id="IRD0MVZVqEiv6o9BHSOckQ" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.3" />
-                              <Container id="qN5GxrLmX0qkdepvpHHoHQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                                <Children>
-                                  <Parameter id="8Jppaa1wMU-rIdd35WptkQ" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                                  <Parameter id="1TFHkP8Xe06PWmmJ6AvSbg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_cae" visible="0" canBeVaried="0" />
-                                </Children>
-                              </Container>
-                            </Children>
-                          </Container>
-                          <Container id="21RvZp9XT0W3h7Oew41etw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule" />
-                        </Children>
-                      </Container>
-                      <Container id="AMHwx5KWXkaMND3mJEQGwg" name="ColonAscendens" description="Colon Ascendens" icon="ColonAscendens" mode="Logical" containerType="Compartment">
-                        <Children>
-                          <Parameter id="P3sji8CQ10aBI4L665NmQg" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="Individual_PKSim.PARAM_Tissue_Weight" visible="0" canBeVaried="1" displayUnit="kg" />
-                          <Parameter id="MlcUnChDy0-QR_opopvqPA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="MucosaVolume.VOLUME_MucosaColonAscendens" visible="1" canBeVaried="1" displayUnit="l" />
-                          <Parameter id="bv1AyK3AB0ajZA8rzpBMUw" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="VascularEndoVolume.VOLUME_VascularEndo_colasc" visible="1" canBeVaried="0" displayUnit="l" />
-                          <Parameter id="x9oaqN-5iEGQ5Ux_booUVg" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_J_iso_Mucosa" visible="1" canBeVaried="1" displayUnit="l/min" />
-                          <Parameter id="XjNFCX8T10mq6lJX7EdmJg" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Q_lymph_mucosa" visible="1" canBeVaried="1" displayUnit="l/min" />
-                          <Parameter id="35WecJ3tB0GSb7oN-78xTA" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Q_mucosa" visible="1" canBeVaried="1" displayUnit="l/min" />
-                          <Parameter id="TGHHjfPMlUeIz0B2zW_HYg" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_f_cell" visible="1" canBeVaried="1" />
-                          <Parameter id="JlgCXxwTbUamRVbKO9US4w" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                          <Parameter id="pLucVGRS2EaHMMGZHbiP4w" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                          <Parameter id="Ei0NK20lQUyeuGx5y-YgGg" name="Fraction mucosa" description="Mucosal fraction of regional intestinal tissue mass" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.19" />
-                          <Parameter id="NVi4gAj_O0yYQEOvXdzitw" name="Fraction of regional blood flow rate" description="Regional blood flow fraction supplying the mucosal tissue of the segment" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.15529" />
-                          <Parameter id="ib3CanAzIkeNWS9dbw86MA" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="4.5E-08" displayUnit="µm" />
-                          <Parameter id="FN1ZYLl9cE2SwjSGh5oZqA" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="2.5E-07" displayUnit="µm" />
-                          <Parameter id="m-KokNKZa06VtCmftmTdeQ" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" visible="1" canBeVaried="1" value="1.86944444444444E-10" displayUnit="ml/min/N" />
-                          <Parameter id="-_oPdHGsOkKxEsImZ3RKYg" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.05" />
-                          <Parameter id="4FtssbZFnkuWvoLdh9BFQA" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.06" />
-                          <Parameter id="t_Gp68Fn6U6wHNJc8qv8ug" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0487" />
-                          <Parameter id="Xdrfd1EyR0y34gUi1Yzs1w" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.13" />
-                          <Parameter id="5lViNoQzn0aEPaX5-Cq6BQ" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.08" />
-                          <Parameter id="76GNGupQaUi54BY9eEVPqA" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0163" />
-                          <Parameter id="30bzc70ZE0WUfkHCuN6dQQ" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.141" />
-                          <Parameter id="JEux6Eaf2kWwxrGgbt000g" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.158" />
-                          <Parameter id="3xZyRsy_yUSgx8HmHU1h5Q" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-                          <Parameter id="2nZW6VD5d06UUrgrWtS7vg" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.718" />
-                          <Parameter id="Ih2NQQm4l02H9g4utLla2Q" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.8" />
-                          <Parameter id="9HwiP1cOnky12jkOvMhitQ" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.73" />
-                          <Parameter id="QPBgXEhDX0-ZEa6lmB5nWw" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0483" />
-                          <Parameter id="wphiu-mKZUurHI7I_z3cyw" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0375" />
-                          <Parameter id="l98OUgMvd0S4VaDKTen7ow" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0182" />
-                          <Parameter id="gGwhEnFDeUWNWuXgZ0XVwQ" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0124" />
-                          <Parameter id="kDP_3LJuok-WBH5YWCyWdg" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.15" />
-                          <Parameter id="MlI0_3zY1kCVVHieJZMvpA" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.282" />
-                          <Parameter id="fjOAja4AKUilsNVMds_EvA" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.456" />
-                          <Parameter id="omScPGpOzk-ktgH2OknmXg" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.78" />
-                          <Parameter id="OimXP6NVlk6WTfAtemKEDA" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="2.41" />
-                          <Parameter id="x8TDgiaDXEejMQAFVS9EHg" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0035" />
-                          <Container id="xNTwHCGTLkad12dHF4Jv1g" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                            <Tags>
-                              <Tag value="ColonAscendens" />
-                              <Tag value="LargeIntestineSegment" />
-                              <Tag value="Mucosa" />
-                            </Tags>
-                            <Children>
-                              <Parameter id="X1-D0dqfCEGc3AvJMD96tQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                              <Parameter id="i9EvJ3NsVEmbwHeVEdJcgA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                              <Container id="g4FHO3kAdkq0VaPUChqJpw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                                <Children>
-                                  <Parameter id="4mTcOuaavE23QBOvV619FA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" visible="0" canBeVaried="0" />
-                                  <Parameter id="sPezkqHC6EewTuAkS3MHgw" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                                </Children>
-                              </Container>
-                            </Children>
-                          </Container>
-                          <Container id="TJ7QlIu16kuyvAuW5cJlaA" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                            <Tags>
-                              <Tag value="ColonAscendens" />
-                              <Tag value="LargeIntestineSegment" />
-                              <Tag value="Mucosa" />
-                            </Tags>
-                            <Children>
-                              <Parameter id="HWHR1-n3WkqJO1thiFwsfg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                              <Parameter id="mgsGJlOnIEmNLP8PKwDFow" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                              <Container id="Fgmna997BUe9W1_ODBkpQg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                                <Children>
-                                  <Parameter id="MCNrlDElnkO8xYNsbKwVbw" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                                  <Parameter id="lIDsFstzAEyb9W5gRVKRfw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" visible="0" canBeVaried="0" />
-                                </Children>
-                              </Container>
-                            </Children>
-                          </Container>
-                          <Container id="NYmmlsqIWU-FZ3jqfSTfNg" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                            <Tags>
-                              <Tag value="ColonAscendens" />
-                              <Tag value="LargeIntestineSegment" />
-                              <Tag value="Mucosa" />
-                            </Tags>
-                            <Children>
-                              <Parameter id="TiWpL1Xm206FmtYvuts8Hw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                              <Parameter id="P3j6Iv7ba0WxqH-8EvwpQA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                              <Parameter id="K7hX26aUTE2pupvTqbqclw" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_pH_INT" visible="1" canBeVaried="1" />
-                              <Container id="iGKTWYLC-0qVDHLsBN0oXg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                                <Children>
-                                  <Parameter id="bqYmKl2v5EqAmq5vC9PwMQ" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                                  <Parameter id="45RE30ThDEO9vSiPiqMqgA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_colasc" visible="0" canBeVaried="0" />
-                                </Children>
-                              </Container>
-                            </Children>
-                          </Container>
-                          <Container id="_1aapd_LZk-snh-NLRJiBg" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                            <Tags>
-                              <Tag value="ColonAscendens" />
-                              <Tag value="IntestinalSecretionSource" />
-                              <Tag value="LargeIntestineSegment" />
-                              <Tag value="Mucosa" />
-                            </Tags>
-                            <Children>
-                              <Parameter id="ZgiOT4ATNkOZWLqz8DBjdg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" visible="0" canBeVaried="0" displayUnit="l" />
-                              <Parameter id="WOXENuU480WsktK0zIwiVw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                              <Parameter id="MhWukXYsCUaCu2UubwxxlA" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.3" />
-                              <Container id="UqmCWC5e6k2-9ygavWyFkw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                                <Children>
-                                  <Parameter id="Pdi3paFV5ESNVrBXYNOlYQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_colasc" visible="0" canBeVaried="0" />
-                                  <Parameter id="lOLaBWIzEkuESlHKv-XLiw" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                                </Children>
-                              </Container>
-                            </Children>
-                          </Container>
-                          <Container id="YpFLOo24U0yvHyKV5AaX2Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule" />
-                        </Children>
-                      </Container>
-                      <Container id="Hags3qjWSUedws7cHYz6Rg" name="ColonTransversum" description="Colon Transversum" icon="ColonTransversum" mode="Logical" containerType="Compartment">
-                        <Children>
-                          <Parameter id="RsM4l3nQrUasWPMWazP3wQ" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="Individual_PKSim.PARAM_Tissue_Weight" visible="0" canBeVaried="1" displayUnit="kg" />
-                          <Parameter id="yGGYSwg16kqYJ8WJF6mepQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="MucosaVolume.VOLUME_MucosaColonTransversum" visible="1" canBeVaried="1" displayUnit="l" />
-                          <Parameter id="cbVmyvnQqUiIFLEL8IRIew" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="VascularEndoVolume.VOLUME_VascularEndo_coltrans" visible="1" canBeVaried="0" displayUnit="l" />
-                          <Parameter id="miCsh8q-HEyIzOGftjoWaw" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Q_lymph_mucosa" visible="1" canBeVaried="1" displayUnit="l/min" />
-                          <Parameter id="ZdG1viejzkm4LDpIKexbgQ" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_J_iso_Mucosa" visible="1" canBeVaried="1" displayUnit="l/min" />
-                          <Parameter id="40mqwU-UTk-qIW6o6tNRFA" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Q_mucosa" visible="1" canBeVaried="1" displayUnit="l/min" />
-                          <Parameter id="3u0AI4TkkEesnEiqc5Qsfw" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_f_cell" visible="1" canBeVaried="1" />
-                          <Parameter id="pAAx5fX9hkSns4SQ65tFsg" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                          <Parameter id="RRDwsc6URkCXYWMR-I_jXg" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                          <Parameter id="Xwm9EBxkbUOKeqFE-XlAXw" name="Fraction of regional blood flow rate" description="Regional blood flow fraction supplying the mucosal tissue of the segment" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.32" />
-                          <Parameter id="LGFiFw7ro0WSeK12RXbBRg" name="Fraction mucosa" description="Mucosal fraction of regional intestinal tissue mass" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.21" />
-                          <Parameter id="hNBFCIZLokKuSDFB7dATIQ" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="4.5E-08" displayUnit="µm" />
-                          <Parameter id="_m_quBn2k0OGw2TLFGrJwQ" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="2.5E-07" displayUnit="µm" />
-                          <Parameter id="QYqhO4Ixzkmw75lr3xnYcw" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" visible="1" canBeVaried="1" value="1.86944444444444E-10" displayUnit="ml/min/N" />
-                          <Parameter id="diaGWmMaM02bE8iIHujhFg" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.05" />
-                          <Parameter id="HgOJ-XK8BUWAMsXShBZ7Xw" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.06" />
-                          <Parameter id="6MarSLBzbUiVygBx_4dpJA" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0487" />
-                          <Parameter id="IVv09N66K0mI54d4HMH14Q" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.12" />
-                          <Parameter id="_ojXQWFqL0-v2vqNaG3r6g" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0163" />
-                          <Parameter id="J88ull2eqUmGYoAoCIvz4Q" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.08" />
-                          <Parameter id="ChwqKGesTESviSqH9QgFhQ" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.158" />
-                          <Parameter id="od6UMA8Eoka7yqAArqeG3Q" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.718" />
-                          <Parameter id="si3NwQEk_kST4L2czcCGYA" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.8" />
-                          <Parameter id="BSHZXxXsh0GON96g4riJng" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-                          <Parameter id="DyIYDUJPPEei377uGPaD8w" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.141" />
-                          <Parameter id="CgnSvSg0Y0KsbipGy9yZ9g" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.74" />
-                          <Parameter id="CbSUUJ8310-rOQeesqssPQ" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0483" />
-                          <Parameter id="45vWeTbI_UupNFWobOKpPA" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0375" />
-                          <Parameter id="LYeKwLDD2EGJx6pMX50qFA" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0182" />
-                          <Parameter id="x4NIrER9vke-R0eaOnT4PQ" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0124" />
-                          <Parameter id="IRAU_zdh4Eu9pwvi2Z6j9A" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.282" />
-                          <Parameter id="IYohDac0_E6CHcP8aXJD2g" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.15" />
-                          <Parameter id="-K2jbDKSp0mrjLmn0CVgjw" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.456" />
-                          <Parameter id="AOiYpqRb0kqm1o9cqJsp7g" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.78" />
-                          <Parameter id="PmeIn9HkH0erJFWRT6nVEQ" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="2.41" />
-                          <Parameter id="dOUqkwdlBkuNcMCT0jZ0Xg" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0035" />
-                          <Container id="E3rvws_AOU-R8ZjRsJ7YJQ" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                            <Tags>
-                              <Tag value="ColonTransversum" />
-                              <Tag value="LargeIntestineSegment" />
-                              <Tag value="Mucosa" />
-                            </Tags>
-                            <Children>
-                              <Parameter id="3zHiQJND7kCVX4vO4Ao5FA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                              <Parameter id="Dq9ET-_1xk2tvtWVoKZhig" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                              <Container id="npX-50LcDEWkbBppr4ZGqA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                                <Children>
-                                  <Parameter id="4BSQ-VKKTE67EbFskhOUMA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" visible="0" canBeVaried="0" />
-                                  <Parameter id="lOaZOcY9B0-4fhiYs3PUEQ" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                                </Children>
-                              </Container>
-                            </Children>
-                          </Container>
-                          <Container id="tHA3JFaL-U-G9uaHbdHBSg" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                            <Tags>
-                              <Tag value="ColonTransversum" />
-                              <Tag value="LargeIntestineSegment" />
-                              <Tag value="Mucosa" />
-                            </Tags>
-                            <Children>
-                              <Parameter id="lVU_QEYDKEWhiWaJ0ULMUw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                              <Parameter id="s8slA9HHSkK_le09XPe90Q" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                              <Container id="3BTPuM6vA0qteXdJNzuBAQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                                <Children>
-                                  <Parameter id="RsOJHcCbgE2Nzt3Gwr6nVQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" visible="0" canBeVaried="0" />
-                                  <Parameter id="Jv9eP1Ev7kiVUzs9pxBBCA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                                </Children>
-                              </Container>
-                            </Children>
-                          </Container>
-                          <Container id="OSCX1Pbj-0qKg7UUO5RmPA" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                            <Tags>
-                              <Tag value="ColonTransversum" />
-                              <Tag value="LargeIntestineSegment" />
-                              <Tag value="Mucosa" />
-                            </Tags>
-                            <Children>
-                              <Parameter id="bvhnZ7ztjUm83HJG8s_m6g" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                              <Parameter id="Sv3sxE-ICEWSMqsInKY7Kg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                              <Parameter id="siCg_3IaukyjdTtBPn2ARg" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_pH_INT" visible="1" canBeVaried="1" />
-                              <Container id="WDvb-wHkpkOhLCCA1I9QEg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                                <Children>
-                                  <Parameter id="11u9t_wEb0CwFHTpfpQ-rw" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                                  <Parameter id="zilGpFOrVUi0uQnY-6OxCA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_coltrans" visible="0" canBeVaried="0" />
-                                </Children>
-                              </Container>
-                            </Children>
-                          </Container>
-                          <Container id="VqzvPjlpO0OJvXYdR5m-rA" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                            <Tags>
-                              <Tag value="ColonTransversum" />
-                              <Tag value="IntestinalSecretionSource" />
-                              <Tag value="LargeIntestineSegment" />
-                              <Tag value="Mucosa" />
-                            </Tags>
-                            <Children>
-                              <Parameter id="EaCpBMbJ5EGSYHucY8LIfQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" visible="0" canBeVaried="0" displayUnit="l" />
-                              <Parameter id="ZtkkJ_Ns0U2cXBUH0SFDHQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                              <Parameter id="3pdS9MwjWE-0RZnS_DYX_Q" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.3" />
-                              <Container id="cuYHoKuAWkC6k8R7m5YAWQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                                <Children>
-                                  <Parameter id="3JzH4MpaBE2VkhCO9-uEIA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                                  <Parameter id="Vpr7EB0PJ0WNKQ0u_TLlSg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_coltrans" visible="0" canBeVaried="0" />
-                                </Children>
-                              </Container>
-                            </Children>
-                          </Container>
-                          <Container id="_nRXkpVsS0WTQ0JX2FwQxg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule" />
-                        </Children>
-                      </Container>
-                      <Container id="VKMppHKTeEqe51szZA0h_A" name="ColonDescendens" description="Colon Descendens / Distal Colon 1" icon="ColonDescendens" mode="Logical" containerType="Compartment">
-                        <Children>
-                          <Parameter id="rJpwwUFxCEe3qw2ereWLqQ" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="Individual_PKSim.PARAM_Tissue_Weight" visible="0" canBeVaried="1" displayUnit="kg" />
-                          <Parameter id="pntfbEORKUS3IJDPuzPXoQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="MucosaVolume.VOLUME_MucosaColonDescendens" visible="1" canBeVaried="1" displayUnit="l" />
-                          <Parameter id="5BZ9QrMskE2dFQtnK4uMPQ" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_J_iso_Mucosa" visible="1" canBeVaried="1" displayUnit="l/min" />
-                          <Parameter id="ZsEHQGW8vEmRQUwwfJY2gA" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Q_lymph_mucosa" visible="1" canBeVaried="1" displayUnit="l/min" />
-                          <Parameter id="o20CB3m0jUO7Y1r9QoSqQA" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="VascularEndoVolume.VOLUME_VascularEndo_coldesc" visible="1" canBeVaried="0" displayUnit="l" />
-                          <Parameter id="VirOrq12yE6eYPnYewfQaQ" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Q_mucosa" visible="1" canBeVaried="1" displayUnit="l/min" />
-                          <Parameter id="duQSZ152hkG11Ke0bbBwQg" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_f_cell" visible="1" canBeVaried="1" />
-                          <Parameter id="AHafxtRkMEyQJhAoIBJFHg" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                          <Parameter id="b56y-rbIdE2KL_IuPbA8Yg" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                          <Parameter id="lmfLFqT97UiGID7ylRbE0g" name="Fraction mucosa" description="Mucosal fraction of regional intestinal tissue mass" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.14" />
-                          <Parameter id="ZK0xt4BcgEaCm4Vy6QnIHw" name="Fraction of regional blood flow rate" description="Regional blood flow fraction supplying the mucosal tissue of the segment" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.24" />
-                          <Parameter id="0EsCBPvT60C1orlAfo57-A" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="4.5E-08" displayUnit="µm" />
-                          <Parameter id="i5TVrqBoMky4AAmoLVSvjg" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="2.5E-07" displayUnit="µm" />
-                          <Parameter id="WK9qAfpDJkOJETLCNR0XnQ" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" visible="1" canBeVaried="1" value="1.86944444444444E-10" displayUnit="ml/min/N" />
-                          <Parameter id="r44dKHowWE-WZeSnZbBf8w" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.05" />
-                          <Parameter id="NRiknCNbfESToJQ6AdDBBA" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0487" />
-                          <Parameter id="uUbecz8ZPEGrr3sdKXxXiw" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.06" />
-                          <Parameter id="0lDuMAq8bE6Shabo0hHuGA" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.12" />
-                          <Parameter id="JiEYYmd7skm00TzAB8K2ig" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.08" />
-                          <Parameter id="XIOn2u66OUWrrxiFqTV9Qg" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0163" />
-                          <Parameter id="vnWxjjXJwE6yqkyUsACDPA" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.158" />
-                          <Parameter id="9nDn5w9DSUq_rQAzhsbMWw" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-                          <Parameter id="g8thhyMm-EOTiMBdYDRW3A" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.141" />
-                          <Parameter id="c8ro-DmE_EGfMRx_EI4EKQ" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.8" />
-                          <Parameter id="wG_pGP89e0aGJcA5Sa4zMA" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.718" />
-                          <Parameter id="b7VkQu4Tx0eeuJp1Ymeukw" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.74" />
-                          <Parameter id="qB50hVZ6t0Gd4p_2hX9SRA" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0375" />
-                          <Parameter id="5ytv9scbdkmhyLPY-7_nog" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0483" />
-                          <Parameter id="R98tkqdHd0Scwm3vMZWJIQ" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0182" />
-                          <Parameter id="xtjOC5FUNkazT1NyX9GIqg" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0124" />
-                          <Parameter id="J1IpFH6eQUOd_aJxqVHmJA" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.15" />
-                          <Parameter id="aQHxZtVlokOeQqBQy3FXfw" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.282" />
-                          <Parameter id="V4bCIDKbTkGqV9zZ50_wyQ" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.78" />
-                          <Parameter id="rTCB5k5JXEqdjK0cine2Ww" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.456" />
-                          <Parameter id="UV0blqNeyEOmLqyoOZl6VQ" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0035" />
-                          <Parameter id="RrqrpUvRwUKKDL_bZ4HUcA" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="2.41" />
-                          <Container id="xjPErKtgLE2tSY7-piU_pw" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                            <Tags>
-                              <Tag value="ColonDescendens" />
-                              <Tag value="LargeIntestineSegment" />
-                              <Tag value="Mucosa" />
-                            </Tags>
-                            <Children>
-                              <Parameter id="eCA8M25IDkOIzaDo-uOqcw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                              <Parameter id="ktFsbLMZO0io9KxzNfFaLg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                              <Container id="UcqVIDIqYEqou1qsFHb7UQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                                <Children>
-                                  <Parameter id="waHkbaIoOkGzY_rSHempTA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" visible="0" canBeVaried="0" />
-                                  <Parameter id="e7_2N7bsK0eFLD4hjYEcRA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                                </Children>
-                              </Container>
-                            </Children>
-                          </Container>
-                          <Container id="wT5qkJMuWE6Wx6caeYjFJQ" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                            <Tags>
-                              <Tag value="ColonDescendens" />
-                              <Tag value="LargeIntestineSegment" />
-                              <Tag value="Mucosa" />
-                            </Tags>
-                            <Children>
-                              <Parameter id="pGgGolxC9kC0CIJY-Xxm0Q" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                              <Parameter id="d7goOjo2fkefPg_Z5PqXMg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                              <Container id="aEQs6Hk7rUGVTuKNmF8WxA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                                <Children>
-                                  <Parameter id="lUbF2aDPeEaZH9YjJmMW9Q" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                                  <Parameter id="dSpb0ozYqEyw4tcgymGRpg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" visible="0" canBeVaried="0" />
-                                </Children>
-                              </Container>
-                            </Children>
-                          </Container>
-                          <Container id="UB8UfObHaEKIJ6imuRVB1g" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                            <Tags>
-                              <Tag value="ColonDescendens" />
-                              <Tag value="LargeIntestineSegment" />
-                              <Tag value="Mucosa" />
-                            </Tags>
-                            <Children>
-                              <Parameter id="UkmRemR1h0Cv12qLdIRWGA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                              <Parameter id="NNNyp2Fe-Um7WGLQRKjSWA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                              <Parameter id="ns3jlxnjFk-nnYTw_aGC7A" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_pH_INT" visible="1" canBeVaried="1" />
-                              <Container id="zlPG2gBiGkSyI7w57UNJEw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                                <Children>
-                                  <Parameter id="IiXlVQelo0-s39hKw2w63w" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                                  <Parameter id="n05gXMSbSEidA6wA26Dl7Q" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_coldesc" visible="0" canBeVaried="0" />
-                                </Children>
-                              </Container>
-                            </Children>
-                          </Container>
-                          <Container id="C0gcpQDNPEiXPW_bEXT9ig" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                            <Tags>
-                              <Tag value="ColonDescendens" />
-                              <Tag value="IntestinalSecretionSource" />
-                              <Tag value="LargeIntestineSegment" />
-                              <Tag value="Mucosa" />
-                            </Tags>
-                            <Children>
-                              <Parameter id="4Z5WBbQrvUeZuSMfigUofQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" visible="0" canBeVaried="0" displayUnit="l" />
-                              <Parameter id="6He4Osm8Tki4dHzK6hnKfA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                              <Parameter id="LtXOhSN8I0Oe0AcKJwbsvA" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.3" />
-                              <Container id="F3jGmowtRUy_yhXdtWm49w" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                                <Children>
-                                  <Parameter id="_eNAC0aP90aOpMyMYcYdoA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                                  <Parameter id="ww_7fHIuCkysbNxEqYTPGg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_coldesc" visible="0" canBeVaried="0" />
-                                </Children>
-                              </Container>
-                            </Children>
-                          </Container>
-                          <Container id="BHDry8HTx0-cg9TpvvX7Sw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule" />
-                        </Children>
-                      </Container>
-                      <Container id="cYeHFKt_XUqY6MLu-xf2_A" name="ColonSigmoid" description="Colon Sigmoid / Distal Colon 2" icon="ColonSigmoid" mode="Logical" containerType="Compartment">
-                        <Children>
-                          <Parameter id="aBAM574ZNUC5PshAasw_mQ" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="Individual_PKSim.PARAM_Tissue_Weight" visible="0" canBeVaried="1" displayUnit="kg" />
-                          <Parameter id="UrmVIzmAjk-3tW2SWykN3w" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="MucosaVolume.VOLUME_MucosaColonSigmoid" visible="1" canBeVaried="1" displayUnit="l" />
-                          <Parameter id="VXwN8MPQ10WgMK6WrvETuw" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_J_iso_Mucosa" visible="1" canBeVaried="1" displayUnit="l/min" />
-                          <Parameter id="UYMHUqt460GaVjmHKlBvRQ" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Q_lymph_mucosa" visible="1" canBeVaried="1" displayUnit="l/min" />
-                          <Parameter id="gMTgCxj9J0uucRHF9nlhUQ" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="VascularEndoVolume.VOLUME_VascularEndo_colsigm" visible="1" canBeVaried="0" displayUnit="l" />
-                          <Parameter id="6gn_vGKhOUuB6eAPLG8WuQ" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Q_mucosa" visible="1" canBeVaried="1" displayUnit="l/min" />
-                          <Parameter id="NzXN3pxagkSen9KYJN2jKg" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_f_cell" visible="1" canBeVaried="1" />
-                          <Parameter id="ASs2Av35QEC2XE3ZmAwozw" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                          <Parameter id="MyTPmK-nEE-GKyPkjTYOuQ" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                          <Parameter id="Cm4MCNyRAEG4TW8keBWnLQ" name="Fraction of regional blood flow rate" description="Regional blood flow fraction supplying the mucosal tissue of the segment" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.135" />
-                          <Parameter id="djhvTR2nM0Gcm6qBBPq5OQ" name="Fraction mucosa" description="Mucosal fraction of regional intestinal tissue mass" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.3" />
-                          <Parameter id="N2gpc53qnUa-cWsrE8Drqg" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="4.5E-08" displayUnit="µm" />
-                          <Parameter id="2JfchczbqkaT6_thAHcMFQ" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="2.5E-07" displayUnit="µm" />
-                          <Parameter id="bGLsNK_MZkixZoKJKCi3dg" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.05" />
-                          <Parameter id="56Y07gqhaEqgbGAyytGf4A" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" visible="1" canBeVaried="1" value="1.86944444444444E-10" displayUnit="ml/min/N" />
-                          <Parameter id="LXhVESRmrUub77IRqfy6_w" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0487" />
-                          <Parameter id="aOYPdgMqAk-G0xfJLVEzYQ" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.06" />
-                          <Parameter id="0fruJDetEUC1NEN_cZpoSA" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.08" />
-                          <Parameter id="Mkt1fXsEe0aKVQfyLUH6Zw" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0163" />
-                          <Parameter id="qY6m1yfo4EyTyMZ-ys7IQQ" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.08" />
-                          <Parameter id="t-Bakz_ogEiC96Gkqb3bkQ" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.8" />
-                          <Parameter id="Iyy0_fpvCU--xnmNkX0B1g" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.141" />
-                          <Parameter id="_Dhs5RHzY0KvMRiVdhWRdQ" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.158" />
-                          <Parameter id="xRDlSVkhp06ynZGOOdu5aw" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-                          <Parameter id="J-XHUON6N06j_h-RPTwOGQ" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.718" />
-                          <Parameter id="JSWd5IP0EUmk36jvspzkJQ" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.78" />
-                          <Parameter id="FeZnOjKqTkuJF-4YcTaRgg" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0483" />
-                          <Parameter id="SghE4vzdVESg4JJ8gjm_DA" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0375" />
-                          <Parameter id="lmck_gxqUkSkp5yCIdRF3Q" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0124" />
-                          <Parameter id="FFxQfUp0hUi_8HCrNFa04w" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0182" />
-                          <Parameter id="Xtek3QKTN0GBXsJpZN0zxg" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.15" />
-                          <Parameter id="hyteutvvmEK_GWHxyiHv5w" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.282" />
-                          <Parameter id="FF_fEzXHok6S5hbgn53wCQ" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.78" />
-                          <Parameter id="z1S4KBk00EutRPIpY3ml_g" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.456" />
-                          <Parameter id="Cm8poWXYHUOsw0a-BbxdwQ" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="2.41" />
-                          <Parameter id="XJEg3z_Gj0S7gVNGpGMrug" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0035" />
-                          <Container id="pJmj_UrpO0ioIgKx0SwyWg" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                            <Tags>
-                              <Tag value="ColonSigmoid" />
-                              <Tag value="LargeIntestineSegment" />
-                              <Tag value="Mucosa" />
-                            </Tags>
-                            <Children>
-                              <Parameter id="OVdJLins3kKvW0s2nNAicw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                              <Parameter id="1osczgwgJEynjimFveRdZA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                              <Container id="ItRC9w0HRE-aMtQkK8Bvzw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                                <Children>
-                                  <Parameter id="HY8xDY45jUOoamzNgXoFCg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" visible="0" canBeVaried="0" />
-                                  <Parameter id="OcSPFyCPfEuAxf2_L1uCXw" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                                </Children>
-                              </Container>
-                            </Children>
-                          </Container>
-                          <Container id="LQuH1MHvJ0af2kvb_nXBJQ" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                            <Tags>
-                              <Tag value="ColonSigmoid" />
-                              <Tag value="LargeIntestineSegment" />
-                              <Tag value="Mucosa" />
-                            </Tags>
-                            <Children>
-                              <Parameter id="5yJ3TVMcQkm9mdmGn_QT4A" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                              <Parameter id="pyrKd7S9rEiRInNze_pbZg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                              <Container id="lz4mOoXV8Euef_kefR7E3Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                                <Children>
-                                  <Parameter id="CZxl-96H7kWiUN6DEtGLMg" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                                  <Parameter id="_lQPBCOtSEasK-jtOO0Bag" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" visible="0" canBeVaried="0" />
-                                </Children>
-                              </Container>
-                            </Children>
-                          </Container>
-                          <Container id="hmTQ2xRfwU-6I_WaFzZk6w" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                            <Tags>
-                              <Tag value="ColonSigmoid" />
-                              <Tag value="LargeIntestineSegment" />
-                              <Tag value="Mucosa" />
-                            </Tags>
-                            <Children>
-                              <Parameter id="jU2F_dZJh0-nJfjI_mtEDA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                              <Parameter id="org4IWo7ykSwKwpFrJfZ0g" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                              <Parameter id="qkZwvivRPEeJHY6dDz9yug" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_pH_INT" visible="1" canBeVaried="1" />
-                              <Container id="T-_4_5MHXUm_W7pdAIaHuQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                                <Children>
-                                  <Parameter id="qWeey3NEwUeTBgUXvqzKsA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                                  <Parameter id="rAP-wNQ98EG6o4xQ3BTSZg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_colsigm" visible="0" canBeVaried="0" />
-                                </Children>
-                              </Container>
-                            </Children>
-                          </Container>
-                          <Container id="UChU1u3Cik-a1gogAusD9g" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                            <Tags>
-                              <Tag value="ColonSigmoid" />
-                              <Tag value="IntestinalSecretionSource" />
-                              <Tag value="LargeIntestineSegment" />
-                              <Tag value="Mucosa" />
-                            </Tags>
-                            <Children>
-                              <Parameter id="xPJKoxIHlEutqqs6YL8_wQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" visible="0" canBeVaried="0" displayUnit="l" />
-                              <Parameter id="BRHEn_EdYEa79TtREb-ItA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                              <Parameter id="5fWkLG9w40mnBDpfzjhJAw" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.3" />
-                              <Container id="7uqmBLsc70aTLZZC5dqXrg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                                <Children>
-                                  <Parameter id="0wKIIzFbjket5m54rgMFIA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                                  <Parameter id="9tobjdlOJUe2dQjuCCQdnA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_colsigm" visible="0" canBeVaried="0" />
-                                </Children>
-                              </Container>
-                            </Children>
-                          </Container>
-                          <Container id="NteNcYyCr0O_9h8y58MLlw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule" />
-                        </Children>
-                      </Container>
-                      <Container id="3iJVLrFIHUq3bKDxKwFnaw" name="Rectum" description="Rectum" icon="Rectum" mode="Logical" containerType="Compartment">
-                        <Children>
-                          <Parameter id="Mawan_h3hUOJTSsBr0sZ-A" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="Individual_PKSim.PARAM_Tissue_Weight" visible="0" canBeVaried="1" displayUnit="kg" />
-                          <Parameter id="vAYESX_mrU2BBEhcyQ-bfw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="MucosaVolume.VOLUME_MucosaRectum" visible="1" canBeVaried="1" displayUnit="l" />
-                          <Parameter id="AJgdiy42jk2Z3Dpp_cGSgA" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Q_lymph_mucosa" visible="1" canBeVaried="1" displayUnit="l/min" />
-                          <Parameter id="Kjq5DWFvzEqa9VyQpEXTXw" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="VascularEndoVolume.VOLUME_VascularEndo_rect" visible="1" canBeVaried="0" displayUnit="l" />
-                          <Parameter id="OKyrt6PciUiCKCqXBrGcjQ" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_J_iso_Mucosa" visible="1" canBeVaried="1" displayUnit="l/min" />
-                          <Parameter id="YUU0FqULTU-vFABRSuzmOQ" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Q_mucosa" visible="1" canBeVaried="1" displayUnit="l/min" />
-                          <Parameter id="tqRf9VmdSkigRKMidDlx6Q" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_f_cell" visible="1" canBeVaried="1" />
-                          <Parameter id="tPrdyG4yM0W336zJqkgC5A" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                          <Parameter id="y6ulukIt-kuzSfqSlUgcGg" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                          <Parameter id="SbinggNT6UeqmjeefGq9vw" name="Fraction of regional blood flow rate" description="Regional blood flow fraction supplying the mucosal tissue of the segment" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.055" />
-                          <Parameter id="robS9WQHUUCRsaSbzPpdcQ" name="Fraction mucosa" description="Mucosal fraction of regional intestinal tissue mass" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.3" />
-                          <Parameter id="Hvbcq6oOp06Jf7LM9Ap9AA" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="4.5E-08" displayUnit="µm" />
-                          <Parameter id="_J97kvIpc0Glz-f6R20qOw" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.05" />
-                          <Parameter id="gdojvG9TpUeT32xM_2GmfQ" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" visible="1" canBeVaried="1" value="1.86944444444444E-10" displayUnit="ml/min/N" />
-                          <Parameter id="PV_cwaT2LE6uMA91Hn6SCg" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="2.5E-07" displayUnit="µm" />
-                          <Parameter id="E5kqnWrm-US6ElrvxqDx9A" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.06" />
-                          <Parameter id="mCekDmzPAUK_ti3pmZjWPg" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0487" />
-                          <Parameter id="Mgljjs1wjE-FdvlDo5agSg" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.08" />
-                          <Parameter id="-0nRU_CgbEGybUGKaCz-Ng" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.08" />
-                          <Parameter id="9v7Cu0r7JEiCcgC8Toem0A" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0163" />
-                          <Parameter id="e9sbkv1IsUaeWTiGT_dxOQ" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.718" />
-                          <Parameter id="undWlVmFG0-luNEP-672lA" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.8" />
-                          <Parameter id="GltQUrxW4UKyIEF-u_wKYg" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.158" />
-                          <Parameter id="P3dDXrt2I0-y-d4ZDEoFQA" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-                          <Parameter id="JJ05vRpSd0iXQWNh-6IgXw" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.141" />
-                          <Parameter id="ixw9tEGn5kaTq9puJZYYIg" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.69" />
-                          <Parameter id="dUzvONjY606hmTSFdGMjLQ" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0483" />
-                          <Parameter id="VpzPJ3fSi0KXGIbQnaOz-w" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0375" />
-                          <Parameter id="X3VdRf6Hrkq41GSh9IdWwg" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0182" />
-                          <Parameter id="dWFV_5sBuUWbenGU99QIqg" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0124" />
-                          <Parameter id="M8bWUkzK9EKcHOjbzJNCHA" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.282" />
-                          <Parameter id="_yYG9_xVGECGwGn1mO42Sw" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.15" />
-                          <Parameter id="BDxOaYTYVUmHyPV_pLTYxg" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.456" />
-                          <Parameter id="kGs8bp3CVkKDhN5hWzlAcw" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.78" />
-                          <Parameter id="QPZh4jqNX0iNIfJix9Lidw" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0035" />
-                          <Parameter id="V6SOpxOsJEmJlfNpqa0MQg" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="2.41" />
-                          <Container id="CXXEeRMxZU-wWTrT4YIzVA" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                            <Tags>
-                              <Tag value="LargeIntestineSegment" />
-                              <Tag value="Mucosa" />
-                              <Tag value="Rectum" />
-                            </Tags>
-                            <Children>
-                              <Parameter id="H-GnQPShi0-yiq5emns1nQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                              <Parameter id="RFAQTi1h7EyMO7cv6qGCLw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                              <Container id="PC0lYCPKyE2tNK1k3cHdoQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                                <Children>
-                                  <Parameter id="WEx4n-rSP0eik3a7m-_nEw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" visible="0" canBeVaried="0" />
-                                  <Parameter id="xODjLglqmkyz4bMkrtIIvw" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                                </Children>
-                              </Container>
-                            </Children>
-                          </Container>
-                          <Container id="A3QoloDj00WaEjb1ONwwKw" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                            <Tags>
-                              <Tag value="LargeIntestineSegment" />
-                              <Tag value="Mucosa" />
-                              <Tag value="Rectum" />
-                            </Tags>
-                            <Children>
-                              <Parameter id="SLprs46gFES0GQpdbHyHOg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                              <Parameter id="GQ3NO0dJwUetk1cyzvbkmA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                              <Container id="OWLHXJ7SpEyiLyjR8Op0ew" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                                <Children>
-                                  <Parameter id="hOFWhJm7HEeejkmzBgO1JQ" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                                  <Parameter id="fA2UkF0zVU-RFXeiIruz4Q" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" visible="0" canBeVaried="0" />
-                                </Children>
-                              </Container>
-                            </Children>
-                          </Container>
-                          <Container id="Ske4CMSGVEmut7Tm9FygjQ" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                            <Tags>
-                              <Tag value="LargeIntestineSegment" />
-                              <Tag value="Mucosa" />
-                              <Tag value="Rectum" />
-                            </Tags>
-                            <Children>
-                              <Parameter id="DbC68L27H0KVoziBYS2pPw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                              <Parameter id="y4kIr-Ir6kaJRBcge5FhrA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                              <Parameter id="x-n8zPv8G0W8X75alUq4yA" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_pH_INT" visible="1" canBeVaried="1" />
-                              <Container id="Dz-jTR2kmESM2QsrDIVbRg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                                <Children>
-                                  <Parameter id="3W029FgWUUqQOqtXJHgx9A" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                                  <Parameter id="KeuwCb07xkGSALmXuoFz3g" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_rect" visible="0" canBeVaried="0" />
-                                </Children>
-                              </Container>
-                            </Children>
-                          </Container>
-                          <Container id="Wg0MyzCwzU6ebHpo_fikEg" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                            <Tags>
-                              <Tag value="IntestinalSecretionSource" />
-                              <Tag value="LargeIntestineSegment" />
-                              <Tag value="Mucosa" />
-                              <Tag value="Rectum" />
-                            </Tags>
-                            <Children>
-                              <Parameter id="x8jYN3S6F02jasW8Y-KILg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" visible="0" canBeVaried="0" displayUnit="l" />
-                              <Parameter id="KogXsBRZ8UmbEniRJ-EgpQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                              <Parameter id="6sKnMesiP0ODqRYn70P-vw" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.3" />
-                              <Container id="Pb6D79dIK0GGxsP4s7siUw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                                <Children>
-                                  <Parameter id="OHl1KU9mlkKHtBABy7yhTA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                                  <Parameter id="Dqfk8oMNK0iNxL-wpXuQ8A" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_rect" visible="0" canBeVaried="0" />
-                                </Children>
-                              </Container>
-                            </Children>
-                          </Container>
-                          <Container id="d7vCSNmn_0mPmGtNL2ePxA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule" />
-                        </Children>
-                      </Container>
-                    </Children>
-                  </Container>
-                </Children>
-              </Container>
-              <Container id="68uNt9I2akWceVNiduAVNg" name="Liver" description="Liver" icon="Liver" mode="Logical" containerType="Organ">
-                <Tags>
-                  <Tag value="TissueOrgan" />
-                </Tags>
-                <Children>
-                  <Parameter id="e5IKA77wrkmApHc_RsrVag" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="Individual_PKSim.PARAM_Tissue_Weight" visible="0" canBeVaried="1" displayUnit="kg" />
-                  <Parameter id="bm6W4BJkdkqW4slkseuIIQ" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="VascularEndoVolume.VOLUME_VascularEndo_liv" visible="1" canBeVaried="0" displayUnit="l" />
-                  <Parameter id="7dhjNHOfiE-PJAIzxQ0GgA" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Lymph_flow_rate_Liver" visible="1" canBeVaried="1" displayUnit="l/min" />
-                  <Parameter id="iLltgbVEnkyz7aRj8LiqEw" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate_Liver" visible="1" canBeVaried="1" displayUnit="l/min" />
-                  <Parameter id="nHlYOocRFk-B3Flsm21aPA" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_f_cell" visible="1" canBeVaried="1" />
-                  <Parameter id="DT5qS_0bX0eC14Jk2XQX6A" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Q_from_Qspec" visible="1" canBeVaried="1" displayUnit="l/min" />
-                  <Parameter id="cK-Hgcb0_E22VVgDts1jWg" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                  <Parameter id="dV5vBiv7KUa_hpo4vtSNVA" name="EHC continuous fraction" description="Fraction of biliary secreted compound continuously entering the duodenum without being temporarily stored in the gallbladder. The fraction of hepatic bile directly entering the duodenum is species-dependent and amounts to about 30-50% in fasted humans to 100% in rats, because the rat lacks a gallbladder." persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" visible="1" canBeVaried="1" value="0" />
-                  <Parameter id="u5NUVZCh-E-UBLJ1iPvejw" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.75" />
-                  <Parameter id="qg5-9c7ZVkmi6AmblD1cIg" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                  <Parameter id="3k4cECEP3k24E5lTCo1EyA" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" visible="1" canBeVaried="1" value="3.88888888888889E-11" displayUnit="ml/min/N" />
-                  <Parameter id="V_UCG7k-z0--k_YZyVs4Xg" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="3.3E-07" displayUnit="µm" />
-                  <Parameter id="ohFMRIBQjEaYKqldVnkXFA" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="9E-08" displayUnit="µm" />
-                  <Parameter id="qldwiGGqXUa9JiFow_WhlA" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.8" />
-                  <Parameter id="VEwdXO5fG0mV9X6mICtvdA" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.069" />
-                  <Parameter id="HR0nkuFZFke_H5vSA5POqQ" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0348" />
-                  <Parameter id="Rpsq5-qUA0mmsFH9Auh5Mg" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.17" />
-                  <Parameter id="cvHY5uHE2EC1xB1qyNioCA" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0252" />
-                  <Parameter id="aWUYBDRSNUOAY4oqF83Z1w" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.184" />
-                  <Parameter id="H0scByCotkiFdszKgWfRkg" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.086" />
-                  <Parameter id="e36ogS32VkaHJ5bgzwh7Ng" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-                  <Parameter id="L0ewiPBL50-PZYugLNqB5w" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.161" />
-                  <Parameter id="OITyRefJuEmsWMGRs-oTuw" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.751" />
-                  <Parameter id="DHPCZHNARkeWMQ6HbA2gSg" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.747" />
-                  <Parameter id="3m6lwyxLSkapQQmUQmNj-w" name="Number of cells/g tissue" description="Number of cells per gram tissue" persistable="0" isFixedValue="0" dim="Count per mass" quantityType="Parameter" visible="0" canBeVaried="1" value="139000" displayUnit="x10^6/g" />
-                  <Parameter id="Go-vUKPe70G3qKkyA2xCKA" name="Microsomal protein mass/g tissue" description="Microsomal protein content per gram tissue" persistable="0" isFixedValue="0" dim="Mass per tissue" quantityType="Parameter" visible="0" canBeVaried="1" value="0.04" displayUnit="mg/g" />
-                  <Parameter id="OACV14cyDEW0FNx3Pp0upA" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.163" />
-                  <Parameter id="xC97_i-azk-Exni8Xfqdjg" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0232" />
-                  <Parameter id="OOGCc6Up5UuIAcWb5BqOiw" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0135" />
-                  <Parameter id="FttnovQ8jE2H85FVaD1xuw" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0472" />
-                  <Parameter id="WzMcyLLzXEitGXpYk1rNXQ" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0238" />
-                  <Parameter id="qcoyGTe1lUySO7dyTh2XVA" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.21" />
-                  <Parameter id="eewg2oHyAE2QTGKEVjiXbA" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.161" />
-                  <Parameter id="W4_kZwQbV0-0PuQD84O-2w" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.481" />
-                  <Parameter id="JH1B0901QUiJeMGTtMVLYQ" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.68" />
-                  <Parameter id="kN1zcew8NUK6FhMdDIJNpg" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="4.56" />
-                  <Parameter id="zAizM2Y9rU6nb-fjX-FFzA" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0088" />
-                  <DistributedParameter id="W0LFWWwy60G-4g9SlPthlw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="hCK1v9f88UC6qNfHPkoH2w" mode="Logical" visible="1" displayUnit="l">
-                    <Children>
-                      <Parameter id="1n060jTEdEGoZo78_IiYaw" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.513257752570375" displayUnit="l" />
-                      <Parameter id="lXxEIi9s1ke9oOBqPNIjFg" name="Mean" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" value="1.89954571193648" displayUnit="l" />
-                      <Parameter id="EL21ig4xeEuv4fEQaK6-sA" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" value="0.444228460417443" displayUnit="l" />
-                    </Children>
-                  </DistributedParameter>
-                  <DistributedParameter id="VRYwlvJhq0yjOBI3xFw2MA" name="Specific blood flow rate" description="Blood flow rate normalized to the organ volume" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" formula="vX9VQTDO-EO9683QII3tUw" mode="Logical" visible="1" displayUnit="ml/min/100g organ">
-                    <Children>
-                      <Parameter id="1tYPngFiMkWPljp_XnpUWw" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" displayUnit="ml/min/100g organ" />
-                      <Parameter id="LvnjBuVPmUObsxmd91kb7Q" name="Mean" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" visible="0" canBeVaried="1" value="0.1794" displayUnit="ml/min/100g organ" />
-                      <Parameter id="xeOUMzWAXEilMo2Z2ktcBQ" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" visible="0" canBeVaried="1" value="0.00897" displayUnit="ml/min/100g organ" />
-                    </Children>
-                  </DistributedParameter>
-                  <Container id="kLQaFdxWjEyQKZou_zICsg" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Liver" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="v4M10qN5wk60MCTBQZhKkw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="HJ1A0jN2d0aPq9fMUWoH1A" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Container id="1xRmTQF-7EafpN1OiOEedg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                        <Children>
-                          <Parameter id="InwDqFPHAkS2KY0VDkkXjQ" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                          <Parameter id="028AHYwu302UWHGzw8k-2w" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" visible="0" canBeVaried="0" />
-                        </Children>
-                      </Container>
-                    </Children>
-                  </Container>
-                  <Container id="yvxjl1guzkC2ZmC3cHheTA" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Liver" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="d1GW6SyeTkmByjHG31z79A" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="8G4Kgdi1K0uNrqqbuYkxbA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Container id="g5rTcQz7zUyLTgvBFDq-LA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                        <Children>
-                          <Parameter id="ktv4-_7TrkC6cyOAcmZ9MA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                          <Parameter id="BzrE_VqCC0eiA6pNiAFe5g" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" visible="0" canBeVaried="0" />
-                        </Children>
-                      </Container>
-                    </Children>
-                  </Container>
-                  <Container id="Ky2hZE0gkU-xY-fmUfJckg" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Liver" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="l9jcbNvX2EuODRqI-AIjBQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="gR3T3iwDUUe_bvzvkpCZjg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Parameter id="kniU_b4POkucVA8VtJ54BQ" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_pH_INT" visible="1" canBeVaried="1" />
-                      <Container id="KiVTCsksX0a3US9zdqu7kg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                        <Children>
-                          <Parameter id="jz9KE9KxkkyIypzxf7gHlg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_liv" visible="0" canBeVaried="0" />
-                          <Parameter id="46ZtxfoYvkWR1WUwM3yXSw" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                        </Children>
-                      </Container>
-                    </Children>
-                  </Container>
-                  <Container id="WiPCGGPb6EybGjmu7KSb3g" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Liver" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="D5WyqBJemkixfEWwDxUqUQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="PO3HPzHzEkGVQEU4mKdauA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Parameter id="v_AZWvXSxkOR7cSgNGtAPQ" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.23" />
-                      <Container id="hr9unE0AlEGsggfo2qv0vA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                        <Children>
-                          <Parameter id="BKYj2KdsJE6km0hn7bGPpw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_liv" visible="0" canBeVaried="0" />
-                          <Parameter id="qgrkXSPwYEG9PG7Hqwxgkg" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                        </Children>
-                      </Container>
-                    </Children>
-                  </Container>
-                </Children>
-              </Container>
-              <Container id="1NHfU3YvTkunbbrtDU6e9g" name="Lung" description="Lung" icon="Lung" mode="Logical" containerType="Organ">
-                <Tags>
-                  <Tag value="TissueOrgan" />
-                </Tags>
-                <Children>
-                  <Parameter id="aX9s5YA970m3oOnTN5agJg" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="Individual_PKSim.PARAM_Tissue_Weight" visible="0" canBeVaried="1" displayUnit="kg" />
-                  <Parameter id="AyTbjPtpc0u3Ops0hoT8kA" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate_Lung" visible="1" canBeVaried="1" displayUnit="l/min" />
-                  <Parameter id="buHCE66HAk29M1XAnLAJ7A" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="VascularEndoVolume.VOLUME_VascularEndo_lng" visible="1" canBeVaried="0" displayUnit="l" />
-                  <Parameter id="QEtT3mQnJE-VYKDHUiNWmg" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Lymph_flow_rate_Lung" visible="1" canBeVaried="1" displayUnit="l/min" />
-                  <Parameter id="UQS009QdnUmpUWXNYbpa_Q" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_f_cell" visible="1" canBeVaried="1" />
-                  <Parameter id="sTGBoIRG8kWdItHpmHHqiw" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Q_lng" visible="1" canBeVaried="1" displayUnit="l/min" />
-                  <Parameter id="OzWRo-1GT0SQ98yp0Y6VSA" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                  <Parameter id="yVM5kmUVPk2p4Mfk8zO_jw" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.75" />
-                  <Parameter id="bmB6uGdgt0urJhRLY45Cfg" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                  <Parameter id="i6H867pDQ02bjFotKqW99w" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" visible="1" canBeVaried="1" value="5.66666666666667E-12" displayUnit="ml/min/N" />
-                  <Parameter id="mmOz3PCQpkqhTRUhgxhgiA" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="2.5E-07" displayUnit="µm" />
-                  <Parameter id="TGOrOM7B9EGnJj3_6GKZGg" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.05" />
-                  <Parameter id="NE-jFDPSnk6B9C1AW8NPsg" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="4.5E-08" displayUnit="µm" />
-                  <Parameter id="LVszf2sVW0mWbwUhhrg8Tg" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.01" />
-                  <Parameter id="tysE01abck-zUuO4ljytig" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.003" />
-                  <Parameter id="fKsV_H44IU6rW-jZMaIl0g" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.009" />
-                  <Parameter id="u59LE9lPm0SSkgVbGlAHdw" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.183" />
-                  <Parameter id="7lUDEni8kUqjJ9ALZ-H24g" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.807" />
-                  <Parameter id="ASUZ2kUN3EiVBj2ibdlZ7A" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.811" />
-                  <Parameter id="ueynVKU6OkyQdSOx8njx0w" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.168" />
-                  <Parameter id="CymX8QaER06KzT9aSm4ADw" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-                  <Parameter id="Xgqhi5e_TEmX6zty13y_kg" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.212" />
-                  <Parameter id="jArOw7cK90GOFQfEHXQ8lw" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.188" />
-                  <Parameter id="B3acfAzYlUS10mUgYigrGg" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0204" />
-                  <Parameter id="K8cbTBkZpE6PjasoEhTb8A" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0215" />
-                  <Parameter id="YcQw4-vkhUmHwjxFHsX27w" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0152" />
-                  <Parameter id="YpUnca-LjkO1jnOCl1rZ2A" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0123" />
-                  <Parameter id="JOIMn0C900m73Uynu6W7fQ" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.11" />
-                  <Parameter id="PrX0NnOQl0KQAxXkJJWs4g" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.336" />
-                  <Parameter id="zeUPROeF1kuiJ-JgY2hcig" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.74" />
-                  <Parameter id="YtmskqRA9UKtnvtUS6v2AQ" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.238" />
-                  <Parameter id="MZcUFjLzvUCdXLY8TZGkBg" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0044" />
-                  <Parameter id="1HuE09IgIkGqedlGYKfF8g" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="3.91" />
-                  <DistributedParameter id="ykcP_b2IxE6DqNkGJOWAiQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="XdCQKEe790qYe1FD9LB3tg" mode="Logical" visible="1" displayUnit="l">
-                    <Children>
-                      <Parameter id="S_HiNgujdEmXAK9OAB-wLw" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.403743139486877" displayUnit="l" />
-                      <Parameter id="yp5nKFHZKU6HzdgEg62V8g" name="Mean" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" value="1.04276351262352" displayUnit="l" />
-                      <Parameter id="EVn-ilA4KEmxo2JkcdC_Ag" name="GeometricDeviation" description="Geometric standard deviation of LogNormal distribution" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1.3" />
-                    </Children>
-                  </DistributedParameter>
-                  <DistributedParameter id="TJUSUyp7eEi167KEHwGUzQ" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="JOWaysd5Nku55XFm4n3plw" mode="Logical" visible="1">
-                    <Children>
-                      <Parameter id="DNUJeFcy_0iN_tLIBsFvTg" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                      <Parameter id="Zh6AE8rGX0K9KFxlAc3WoQ" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.58" />
-                    </Children>
-                  </DistributedParameter>
-                  <Container id="S9nTwpXAk0mjoLYsPZDHhA" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Lung" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="5fEV7rSSK0ufAkCQyUGl-A" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="YeJOBqBgM0yEJ9QWbUIppg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Container id="EoWWSBqczEiG2vz2yYLGbQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                        <Children>
-                          <Parameter id="4nQGryaljk2-ikAnaZs08Q" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                          <Parameter id="MbmhnGGLykGap0jwzPPpdw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" visible="0" canBeVaried="0" />
-                        </Children>
-                      </Container>
-                    </Children>
-                  </Container>
-                  <Container id="sntQYIleCUO8SGMqvmOx9A" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Lung" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="rdSk3FGrQ0WLkvmXLXiYnw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="8z9QjTXkfUG4Sl4nbpaO2Q" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Container id="yHMQaKPKp02DihOtzxh18A" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                        <Children>
-                          <Parameter id="7Vq7cnlubEmWh02Ozu3svQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" visible="0" canBeVaried="0" />
-                          <Parameter id="cV296wjENkqDd3RHcCyYlw" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                        </Children>
-                      </Container>
-                    </Children>
-                  </Container>
-                  <Container id="l67dYbDruk65Ld_SSqhXGg" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Lung" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="nnxupR60REGUetu3mfps7A" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="6f_nYryGWUGffz_ISMa0cA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Parameter id="oo0yclk34kiesirda3ysrQ" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_pH_INT" visible="1" canBeVaried="1" />
-                      <Container id="CcSwUHEzQkeLMIa7oo83yQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                        <Children>
-                          <Parameter id="z1kxDo2KrEyIpwspHzXAOg" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                          <Parameter id="F6WMQBJijkaJy-JMNOuw2w" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_lng" visible="0" canBeVaried="0" />
-                        </Children>
-                      </Container>
-                    </Children>
-                  </Container>
-                  <Container id="ay3McSvbZkqRugX8fq_pag" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Lung" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="JJPso-fZykWWPCdWCTwTFQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="fGEzUnGFS0azJnZ-w7eVLw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Parameter id="bFbzLIJAhEe9M4QM-DCrog" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="6.6" />
-                      <Container id="i19a2BgUIk6VN-8bUS6CQg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                        <Children>
-                          <Parameter id="kdBjNudXH0aehZQsF_hfBA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                          <Parameter id="z2oRzZyAk0mB7KLeXtUV6w" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_lng" visible="0" canBeVaried="0" />
-                        </Children>
-                      </Container>
-                    </Children>
-                  </Container>
-                </Children>
-              </Container>
-              <Container id="cFodjlKXqk-iSGVKNrmpUQ" name="Muscle" description="Muscle" icon="Muscle" mode="Logical" containerType="Organ">
-                <Tags>
-                  <Tag value="TissueOrgan" />
-                </Tags>
-                <Children>
-                  <Parameter id="Y05FBtbKDkuSRVuc0FkDcQ" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="Individual_PKSim.PARAM_Tissue_Weight" visible="0" canBeVaried="1" displayUnit="kg" />
-                  <Parameter id="o2t6w3386UGUw6xoajFeXA" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Lymph_flow_rate_Muscle" visible="1" canBeVaried="1" displayUnit="l/min" />
-                  <Parameter id="BxobAF2y30qJ9Dq95MdnSQ" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate_Muscle" visible="1" canBeVaried="1" displayUnit="l/min" />
-                  <Parameter id="jl6hb3J-RU2S8f0EsSk26w" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="VascularEndoVolume.VOLUME_VascularEndo_mus" visible="1" canBeVaried="0" displayUnit="l" />
-                  <Parameter id="nvji4D1_AUa6wJih_RK6ug" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_f_cell" visible="1" canBeVaried="1" />
-                  <Parameter id="Kiij3BrO30WoYgzrh40Zeg" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Q_from_Qspec" visible="1" canBeVaried="1" displayUnit="l/min" />
-                  <Parameter id="WZsWSo70SE2HenomjY85Ug" name="Peripheral blood flow fraction" description="Blood flow fraction in organ used for calculation of peripheral venous blood concentrations" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" visible="1" canBeVaried="1" value="0.287" />
-                  <Parameter id="8-cMXrZkYEm_PW2qThxnuA" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                  <Parameter id="DLyJP1DnA0i-vq0EoYLj-w" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="2" />
-                  <Parameter id="WUYAcwtQC0CUhy65PACBWg" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                  <Parameter id="nKWZjgKRm0OjaZg5UNbjzg" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" visible="1" canBeVaried="1" value="4.16666666666667E-12" displayUnit="ml/min/N" />
-                  <Parameter id="7Rpw9O_QS0K0JsmwkB52eA" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="2.5E-07" displayUnit="µm" />
-                  <Parameter id="u0LxEGjp6kSHTNEO7jFMyA" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.05" />
-                  <Parameter id="JN1fojy7pEWAXMcIgaN-uA" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="4.5E-08" displayUnit="µm" />
-                  <Parameter id="Hzf74wgT7kazi1CnvYz66g" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.025" />
-                  <Parameter id="BEuUYGZcpEyV_lCr54kV4g" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.064" />
-                  <Parameter id="90ElpU2x_0ihpL2K5SHbmA" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.059" />
-                  <Parameter id="HsK6vlmRCEeFWhUO5X_jmA" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-                  <Parameter id="ophAL1lbqkaq62cX7tfEzg" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="2.42" />
-                  <Parameter id="DxY8CCjSLU6zYglhJyCr1w" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0009" />
-                  <DistributedParameter id="8ro8SKLVWEmzeWZt838G1w" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="Y8rX_o0cQ0mQgbjPuULn2A" mode="Logical" visible="1" displayUnit="l">
-                    <Children>
-                      <Parameter id="YwZkVif0HESB-TwKT3YP9A" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.534700213215445" displayUnit="l" />
-                      <Parameter id="PWQrRGYOdUu4q_CaZOdDhg" name="Mean" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" value="26.0528937105536" displayUnit="l" />
-                      <Parameter id="8MmdPUZOsEKZZfhdf8Ad6g" name="GeometricDeviation" description="Geometric standard deviation of LogNormal distribution" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1.1" />
-                    </Children>
-                  </DistributedParameter>
-                  <DistributedParameter id="5IIRBf7U1kCc4L1kYww6qQ" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="yornantdUUyUTe6Y8Grpxw" mode="Logical" visible="1">
-                    <Children>
-                      <Parameter id="Mpg8hAL3hUu01Vjb7dxpGQ" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                      <Parameter id="M0GSAi9BBkyPj11eiHizow" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.013" />
-                    </Children>
-                  </DistributedParameter>
-                  <DistributedParameter id="YXZlsuEcykaxmCJRz0roTQ" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="lmKg6vBoRUegkDvYobY0Eg" mode="Logical" visible="1">
-                    <Children>
-                      <Parameter id="diSbQ-SzJEmj9D4ZmmHEow" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                      <Parameter id="c4PVQrWiRU-DiP-SdNSvxQ" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0238" />
-                    </Children>
-                  </DistributedParameter>
-                  <DistributedParameter id="fhrEiHJCeUKpN9j4E3A3CA" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Yn9O8BGW6EWWviNExqK-yw" mode="Logical" visible="1">
-                    <Children>
-                      <Parameter id="JGQPx8CBDk6ol2ZfDOrkoA" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                      <Parameter id="xRVEcCOtmkS5Ri2Lusgqag" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0072" />
-                    </Children>
-                  </DistributedParameter>
-                  <DistributedParameter id="tYM4guw0-kKbmcHF1F1UDw" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="-XBc4pAx90-eyQuAdUHQKQ" mode="Logical" visible="1">
-                    <Children>
-                      <Parameter id="zmkQy7y_AUqevRn5AL0kAw" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                      <Parameter id="kqdeVQOlSUq7EkEghQXj2Q" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.177" />
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-                  <DistributedParameter id="M9XdCpP3V0GPGycmJp0ptQ" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Wj6t-DKA2U6JPNxtyqBqxQ" mode="Logical" visible="1">
-                    <Children>
-                      <Parameter id="F6l6CpqtjkCGcMj1FPiOzw" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                      <Parameter id="Jur8_3hgM02Xi_ONICLi3A" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.16" />
-                    </Children>
-                  </DistributedParameter>
-                  <DistributedParameter id="e0QdgX97NEeeitOHI0dV-g" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="jsqEDNOk7kiZFMj260kWFg" mode="Logical" visible="1">
-                    <Children>
-                      <Parameter id="33Wvhr_SL0KNKRl0kfIgPg" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                      <Parameter id="ug5S5eZiekKh95rqTJGoxA" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.76" />
-                    </Children>
-                  </DistributedParameter>
-                  <DistributedParameter id="-4qV3D5jnkaZPXv-LHqn8g" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="zCdO-H86akq8orIEg7iBNg" mode="Logical" visible="1">
-                    <Children>
-                      <Parameter id="YLFs0QBjDkKOTbC1aExb0g" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                      <Parameter id="FyryxmMH7kaCW3sZDqDp0w" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.811" />
-                    </Children>
-                  </DistributedParameter>
-                  <DistributedParameter id="xhYb7S8JYE2EWEzBrpIDsQ" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="4izQ8bd6vEiACKkcqSUb0Q" mode="Logical" visible="1">
-                    <Children>
-                      <Parameter id="JwNh4jCnS0-pAFDgJXl4Og" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                      <Parameter id="sE9_asFgFEiQlRoQN3Ad1g" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.022" />
-                    </Children>
-                  </DistributedParameter>
-                  <DistributedParameter id="FUEtulBTGUiqopiNC3cKPw" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="apaQnWC1R0mkdjhDCTCN-A" mode="Logical" visible="1">
-                    <Children>
-                      <Parameter id="hikrOmCKbUqRFSx4zQm_JA" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                      <Parameter id="X0zYZRI66kumf4bUBxtGBg" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0049" />
-                    </Children>
-                  </DistributedParameter>
-                  <DistributedParameter id="8RyvpRZT90enG2G8QLWq6g" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="aroJrJCidUC41UJZ0qqpSg" mode="Logical" visible="1">
-                    <Children>
-                      <Parameter id="vrz6bi1kyU20i39_9AtnjA" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                      <Parameter id="mo2r76hLUU-m-ZHUx9OwUQ" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0078" />
-                    </Children>
-                  </DistributedParameter>
-                  <DistributedParameter id="vibxWP3ZUE-HAjcBCvCzzQ" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="EZ16uJUmxky-L0cyidKiEg" mode="Logical" visible="1">
-                    <Children>
-                      <Parameter id="ndkMC6Alak2efMez83zpeQ" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                      <Parameter id="65VttTmjNEiscGtwN5WzHg" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0042" />
-                    </Children>
-                  </DistributedParameter>
-                  <DistributedParameter id="3q11PFWvME62pdlMXoLCFw" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Cd3xvocf6UykHAfN8w9DIw" mode="Logical" visible="1">
-                    <Children>
-                      <Parameter id="qv1_183VLUG2ql8QTVtr2Q" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                      <Parameter id="0mlnQ77Oik-bLrDXgBcfNA" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.079" />
-                    </Children>
-                  </DistributedParameter>
-                  <DistributedParameter id="v3estWiiQEq9Y7RwTxPrKQ" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="gvj2SHge5UmWjBbSrA_jLg" mode="Logical" visible="1">
-                    <Children>
-                      <Parameter id="JKuLJId2w061iKe4lZSmRA" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                      <Parameter id="MZFJFITppEKFQALPQlTRPQ" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.19" />
-                    </Children>
-                  </DistributedParameter>
-                  <DistributedParameter id="xtCx2Z3qOkem5HFzlKVsAQ" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Yl_tpy9xa0q8-WXbAPkjRw" mode="Logical" visible="1">
-                    <Children>
-                      <Parameter id="Oe5HAGzJB0-IkXLz5Dt5SA" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                      <Parameter id="26k3zoTUqkmH0BOf4Kbb2w" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.666" />
-                    </Children>
-                  </DistributedParameter>
-                  <DistributedParameter id="1Njc9MrgGUOEmWBopUyJMg" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="3axkvavtF0-lwm_8sylxvw" mode="Logical" visible="1">
-                    <Children>
-                      <Parameter id="r3arlO2S-Ey1HxN330OUMQ" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                      <Parameter id="dPacOSkNMk2BhVru5skVGw" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.76" />
-                    </Children>
-                  </DistributedParameter>
-                  <DistributedParameter id="dwQ2cKbIN069oSdNxIqj2w" name="Specific blood flow rate" description="Blood flow rate normalized to the organ volume" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" formula="iglelZ00bUCAd9xdA0cIZw" mode="Logical" visible="1" displayUnit="ml/min/100g organ">
-                    <Children>
-                      <Parameter id="m4vus5BW3UW9BuNq8ZCc1A" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" displayUnit="ml/min/100g organ" />
-                      <Parameter id="UvvuwT_1W0-XfCYdgSCB_A" name="Mean" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" visible="0" canBeVaried="1" value="0.03419" displayUnit="ml/min/100g organ" />
-                      <Parameter id="0PtdYq8PlUWjrJC3o2Sd_Q" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0017095" displayUnit="ml/min/100g organ" />
-                    </Children>
-                  </DistributedParameter>
-                  <Container id="yw1lF6NGzUebqB1RzY5lcA" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Muscle" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="ju6qZD0cN0C8nFq-to_6oA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="y67-Dfjvpkef231Bdn_pkQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Container id="v6uo2e2jcUCHg6I954vdXA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                        <Children>
-                          <Parameter id="AKSaO63eS0mmvWgcOjV-KA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                          <Parameter id="91VaTS1kIUyf8pPuXhQ03Q" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" visible="0" canBeVaried="0" />
-                        </Children>
-                      </Container>
-                    </Children>
-                  </Container>
-                  <Container id="zqX6cO98Rk-cr016qGkvtQ" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Muscle" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="TUyTG4pMnkmUk-u0j3Gb_Q" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="b5Gio-YmWk2YZSXFscfFhw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Container id="0MvW-0rVmk-6HekRbK42Mg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                        <Children>
-                          <Parameter id="3VDf2Bk7Y0OQFEAYlt7VHw" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                          <Parameter id="kbjPd6lHqkmNZoHN2JVY0g" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" visible="0" canBeVaried="0" />
-                        </Children>
-                      </Container>
-                    </Children>
-                  </Container>
-                  <Container id="dCF3JWTh6USnRi-gPC27TQ" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Muscle" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="dwMO5J9JTEGphFB5WJhG7w" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="zhfQqMU3PUiCxRhUHFC34w" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Parameter id="1mHxIcZZ80-7q4IGkRSh7Q" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_pH_INT" visible="1" canBeVaried="1" />
-                      <Container id="00r8WWT7k0ymJ-eLafqSjg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                        <Children>
-                          <Parameter id="xviVyZz4t0Sqj2jLnUeJcA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                          <Parameter id="btIhqZZmqE21dAb_cPKtmQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_mus" visible="0" canBeVaried="0" />
-                        </Children>
-                      </Container>
-                    </Children>
-                  </Container>
-                  <Container id="YvELcqn1Aky_A9v0A1I89A" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Muscle" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="arljOdn-PEWzkaaQ7cgEJg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="kOXMirx7TUyb2GIv_6pvEQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Parameter id="plDZYt9j8kyrS5brFt4RvQ" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="6.81" />
-                      <Container id="VcJ3BhTSAU2QXrhZhX6jqg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                        <Children>
-                          <Parameter id="devsGlaCzkCmYKJ5NIoOfA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_mus" visible="0" canBeVaried="0" />
-                          <Parameter id="SgpojLL650yPIwcrVF2cow" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                        </Children>
-                      </Container>
-                    </Children>
-                  </Container>
-                </Children>
-              </Container>
-              <Container id="yixpA99D7kGPx5hmMeQ9zQ" name="Pancreas" description="Pancreas" icon="Pancreas" mode="Logical" containerType="Organ">
-                <Tags>
-                  <Tag value="Portal Vein Supplying Organ" />
-                  <Tag value="TissueOrgan" />
-                </Tags>
-                <Children>
-                  <Parameter id="WzWA-toRXUe5IdDdv7sHpQ" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="Individual_PKSim.PARAM_Tissue_Weight" visible="0" canBeVaried="1" displayUnit="kg" />
-                  <Parameter id="YtPoeiIZz0q6NZR14D1jJw" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="VascularEndoVolume.VOLUME_VascularEndo_pan" visible="1" canBeVaried="0" displayUnit="l" />
-                  <Parameter id="dMj6dRFYSU2tASq_ghgndw" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Lymph_flow_rate_Pancreas" visible="1" canBeVaried="1" displayUnit="l/min" />
-                  <Parameter id="aW8gJJ-MZk-mmb3z-B2p8Q" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate_Pancreas" visible="1" canBeVaried="1" displayUnit="l/min" />
-                  <Parameter id="ODOa2pW4skekOe87VlaDow" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_f_cell" visible="1" canBeVaried="1" />
-                  <Parameter id="FfXFyACrqkyVcdnJNdgKaA" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Q_from_Qspec" visible="1" canBeVaried="1" displayUnit="l/min" />
-                  <Parameter id="OiymGkkcdEC9OXvCXSPbaw" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                  <Parameter id="r_mAeBIQfU-NGeXKAM3X-w" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.75" />
-                  <Parameter id="ArdqZNThwEGBl-cDKloLTw" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                  <Parameter id="mW4ErI-JP0yTcl-l3sf-hA" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.05" />
-                  <Parameter id="7Bot_dXDrE219Me7pOMTyg" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" visible="1" canBeVaried="1" value="3.22222222222222E-11" displayUnit="ml/min/N" />
-                  <Parameter id="9hu9kBJl2kyJ_ff5YrzIXw" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="2.5E-07" displayUnit="µm" />
-                  <Parameter id="48gHM0CEcEWmngh_FHc3LQ" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="4.5E-08" displayUnit="µm" />
-                  <Parameter id="UHOd4a5N30GR-4apTuD1qA" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.08" />
-                  <Parameter id="CkhZSNJgMUKqTPECZoOsCw" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0403" />
-                  <Parameter id="1xhleW78AUmi9p_J9Cjb6g" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.2" />
-                  <Parameter id="KEOJvWDWS0WMuyEeYk1_1g" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.01067" />
-                  <Parameter id="SJiCMVE7n02JBBDa_lylng" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.13" />
-                  <Parameter id="MkLwQtMLd0egy1aV3LchdA" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.06" />
-                  <Parameter id="MrjCfZUUNkSuEt3MvheoPA" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.71" />
-                  <Parameter id="hViAkQy-FUmJ20_MvSqW1w" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.06" />
-                  <Parameter id="VNRUp2G0L0uvVXr3Cr6leA" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.71" />
-                  <Parameter id="nDELMvmBj0yEMZcb48Bp1g" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-                  <Parameter id="ueVK7waqf0CVK2w2oIQscA" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.12" />
-                  <Parameter id="yfIlaLQBxEy01f-PTFuE3Q" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0403" />
-                  <Parameter id="2MgcIeMU2EeqWffmSEvUtA" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0403" />
-                  <Parameter id="9-7Dj_M8c0-P22Oe870xoA" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.009" />
-                  <Parameter id="NFP-GvYFZUqcC1BtP7sx1Q" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.009" />
-                  <Parameter id="qFYpHEUsjkiHF_B69_E24g" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.13" />
-                  <Parameter id="jH6ByArT0E6Yhtx4ukfgdA" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.12" />
-                  <Parameter id="_zhz4YlO_EqRgSKl3JezPA" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.71" />
-                  <Parameter id="uQ5SdDR52EqngibXoVTW0g" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.521" />
-                  <Parameter id="9dHTFkNww020NSDqCU04Yg" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.00167" />
-                  <Parameter id="89YaqZWv5UGCfs0aI-A1_A" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="1.67" />
-                  <DistributedParameter id="uehFgNzfR0OjHe6TuuWlhw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="6Qpmxy3Cv0iC9SuRwH2Xmg" mode="Logical" visible="1" displayUnit="l">
-                    <Children>
-                      <Parameter id="VhbnxfOp10-GuiusA31OzQ" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.500987716776352" displayUnit="l" />
-                      <Parameter id="9LRePlixlkKr9XP_Ea9cYQ" name="Mean" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" value="0.153282906300256" displayUnit="l" />
-                      <Parameter id="FENqiyCx4UWLDulEUePaXA" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0412103529546573" displayUnit="l" />
-                    </Children>
-                  </DistributedParameter>
-                  <DistributedParameter id="mu5MsfhhxUqaQiBQBHvkQg" name="Specific blood flow rate" description="Blood flow rate normalized to the organ volume" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" formula="dJzmMnfaekiojqSMPy2oDg" mode="Logical" visible="1" displayUnit="ml/min/100g organ">
-                    <Children>
-                      <Parameter id="ErevUQMwtkiBcp2qo40uqg" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" displayUnit="ml/min/100g organ" />
-                      <Parameter id="M-X62Et0dkyFJAAlV3QApw" name="Mean" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" visible="0" canBeVaried="1" value="0.3419" displayUnit="ml/min/100g organ" />
-                      <Parameter id="aJAMlisQf02Q6JpexAMUcA" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" visible="0" canBeVaried="1" value="0.017095" displayUnit="ml/min/100g organ" />
-                    </Children>
-                  </DistributedParameter>
-                  <Container id="XpMoC77tqU2dbzFapP7yNA" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Pancreas" />
-                      <Tag value="Portal Vein Supplying Organ" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="ofzTfPuL4k6XypjRtQNKNQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="n4nwCOrDVEegniT7tswlUg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Container id="kMdUXWgkzU-eIrUzuOcccQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                        <Children>
-                          <Parameter id="nd012faIL0mj0wcqmkLFig" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" visible="0" canBeVaried="0" />
-                          <Parameter id="913hUHuxekOogQ0h1qAE8A" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                        </Children>
-                      </Container>
-                    </Children>
-                  </Container>
-                  <Container id="cE6Ep5Tc7ESxE43Touo5cw" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Pancreas" />
-                      <Tag value="Portal Vein Supplying Organ" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="uowkoKSjck-brwgw_A7QVA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="DN_t1wOujEmcjVa2FoAZ_A" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Container id="usKna3BG9EObqvXqZv25lA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                        <Children>
-                          <Parameter id="z1dJWV2jZEu9wKRwPwVxrA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                          <Parameter id="6C_sWC-7qUSNky03l2Qqjg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" visible="0" canBeVaried="0" />
-                        </Children>
-                      </Container>
-                    </Children>
-                  </Container>
-                  <Container id="pqwFSmbk-EayJEjapSwGkg" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Pancreas" />
-                      <Tag value="Portal Vein Supplying Organ" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="BCUYVP8HWkWuC1kwrjNTOw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="p7HtWKHJEUeGFPnSfsYnKA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Parameter id="LK7dao0_QUm_Ub-MsdV4RA" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_pH_INT" visible="1" canBeVaried="1" />
-                      <Container id="IkX2ROPDwUKMw9Pdj9RtUQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                        <Children>
-                          <Parameter id="f_HhoZtI5kOS8ONAmu3YnA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_pan" visible="0" canBeVaried="0" />
-                          <Parameter id="m4rMVflkz0CO54yKGb5Nbw" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                        </Children>
-                      </Container>
-                    </Children>
-                  </Container>
-                  <Container id="tC2LTXmkVkuQv6mD-Lzfig" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Pancreas" />
-                      <Tag value="Portal Vein Supplying Organ" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="Ff7ZmJG68kKlqiyj1cheTg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="IzxCCGlcUUO0DyJqLl6Aqg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Parameter id="Tz0OvwPDNk6moRJlqC_zQw" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.4" />
-                      <Container id="1U3PnXNvkEOtdV-hzFYdxw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                        <Children>
-                          <Parameter id="YmnY3z9kY02Iu6te65tqzA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_pan" visible="0" canBeVaried="0" />
-                          <Parameter id="q2Bw0eXT1EaIW-e26D13rQ" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                        </Children>
-                      </Container>
-                    </Children>
-                  </Container>
-                </Children>
-              </Container>
-              <Container id="Gu0B5D5pIUCvs6IxMkDzKw" name="PortalVein" description="PortalVein" icon="PortalVein" mode="Logical" containerType="Organ">
-                <Tags>
-                  <Tag value="BloodOrgan" />
-                </Tags>
-                <Children>
-                  <Parameter id="osIW6gXHhUCdaHSe2CJVRw" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="Individual_PKSim.PARAM_Tissue_Weight" visible="0" canBeVaried="1" displayUnit="kg" />
-                  <Parameter id="nyyNtBo_jUiDXAOU8_irdQ" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Q_Lymph_pve" visible="1" canBeVaried="1" displayUnit="l/min" />
-                  <Parameter id="sRyPz4e2p0Of16GgSuTYCA" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Q_pve" visible="1" canBeVaried="1" displayUnit="l/min" />
-                  <Parameter id="6oGkuc1kRUSIJ-XLXNX0Cg" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                  <Parameter id="QVdU3DyxU0WJ5HZjPGWUkg" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="0" value="0.75" />
-                  <Parameter id="BugDsTCc7k-KrkdY8hqCiA" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="1" />
-                  <DistributedParameter id="OXEgwWcmRkmwBNJGoFf13g" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="GiwjOS90A0u31I0_VFzNkQ" mode="Logical" visible="1" displayUnit="l">
-                    <Children>
-                      <Parameter id="8fFCfrAgC0GdbwiQ_WLAkw" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.501110815503086" displayUnit="l" />
-                      <Parameter id="HIWAWCgqs0uCxSwm1EHJzA" name="Mean" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" value="0.83561581977504" displayUnit="l" />
-                      <Parameter id="MrPZ3TBNuUCSRAHSvRX1Nw" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" value="0.041780790988752" displayUnit="l" />
-                    </Children>
-                  </DistributedParameter>
-                  <Container id="-btXNr8mOEG_8ZCjsspLow" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="BloodOrgan" />
-                      <Tag value="PortalVein" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="O46_JToVp0SMZbC4zAKbig" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="Z2mu5qb0aEaYkG3vGWWyXw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_pls_BloodOrgan_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Container id="mhl3ymwtKk651ifBq4txqw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                        <Children>
-                          <Parameter id="45OeKhiafU2xB_VQWkpDyA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" visible="0" canBeVaried="0" />
-                          <Parameter id="A6V3BjOw5E6zu06qK5wiNw" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                        </Children>
-                      </Container>
-                    </Children>
-                  </Container>
-                  <Container id="ghMacG-81kSUPN5wkgPsnA" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="BloodOrgan" />
-                      <Tag value="PortalVein" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="WwQnzwCbUU2oNWlj2cSi2w" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="7FO6VfZ-xUWXC9W50WxEcg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_bc_blood_organ_4comp" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Container id="sAR0KioR90W2-sGW4IIdaw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                        <Children>
-                          <Parameter id="VTP2GPlFWkKurbgJFF2VCQ" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                          <Parameter id="IBvpT38dO02DbU10SwM-wQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" visible="0" canBeVaried="0" />
-                        </Children>
-                      </Container>
-                    </Children>
-                  </Container>
-                </Children>
-              </Container>
-              <Container id="WfLr97AqvkWZzgZ2_DssKg" name="Skin" description="Skin" icon="Skin" mode="Logical" containerType="Organ">
-                <Tags>
-                  <Tag value="TissueOrgan" />
-                </Tags>
-                <Children>
-                  <Parameter id="woZrTcUjAE28VS3cBLq5SQ" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="Individual_PKSim.PARAM_Tissue_Weight" visible="0" canBeVaried="1" displayUnit="kg" />
-                  <Parameter id="Sr1jh1KHq0qT9QsImdBm5g" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="VascularEndoVolume.VOLUME_VascularEndo_skn" visible="1" canBeVaried="0" displayUnit="l" />
-                  <Parameter id="l1DQX67QEEa9od4BMgcpgg" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate_Skin" visible="1" canBeVaried="1" displayUnit="l/min" />
-                  <Parameter id="2CegWxyB_0K5jDp9c1pZlA" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Lymph_flow_rate_Skin" visible="1" canBeVaried="1" displayUnit="l/min" />
-                  <Parameter id="c9I0zbR5NUyUmAOTjRPYOQ" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_f_cell" visible="1" canBeVaried="1" />
-                  <Parameter id="YXy4J2x23kaRARhu_1BbdQ" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Q_from_Qspec" visible="1" canBeVaried="1" displayUnit="l/min" />
-                  <Parameter id="URZQyWY7OUSieU5e2LjyKw" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                  <Parameter id="Pq5JKCBu5EC80O85lxIhuw" name="Peripheral blood flow fraction" description="Blood flow fraction in organ used for calculation of peripheral venous blood concentrations" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" visible="1" canBeVaried="1" value="0.713" />
-                  <Parameter id="DlFVvkZAu0-3h0mu64udVg" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1.6" />
-                  <Parameter id="-v3Wc3mpDk-3h7lZ6kB7KA" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                  <Parameter id="-TNAq6hhUU6c0cHpkAqUpg" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.05" />
-                  <Parameter id="PjizWmYeSUCtiJHVYUzagQ" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" visible="1" canBeVaried="1" value="1.66666666666667E-12" displayUnit="ml/min/N" />
-                  <Parameter id="6BQQsFuOj0StfkDt1pTbEg" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="2.5E-07" displayUnit="µm" />
-                  <Parameter id="Q-Xnrtw-5ESWis7RxOELEQ" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="4.5E-08" displayUnit="µm" />
-                  <Parameter id="wFmNdTXsPUe0ErD-jeRXTA" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0284" />
-                  <Parameter id="SYQyMA4ufEWQTq8vVXaOFQ" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.1" />
-                  <Parameter id="Hkb7Ult-FkSbz_f3-oS3KA" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.046" />
-                  <Parameter id="kZbexoOTCUmOCCHAzx2ZYg" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0111" />
-                  <Parameter id="LcAtYE1nnUqqW2lTxAF3lA" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.288" />
-                  <Parameter id="fOPzQLWiCUW6DLqgWwIXAQ" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.718" />
-                  <Parameter id="MtDoiT2TDkK2t3Jeu1gvCg" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.612" />
-                  <Parameter id="DGHvMzSM_U20iGSK-0ZUKA" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.096" />
-                  <Parameter id="Btya-rGOV0ehCSp4ZDNHoA" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.277" />
-                  <Parameter id="mQaDlA8UVkC0QxAuzBmUrQ" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-                  <Parameter id="HA4w5kp15kKYjgPAyP6-Vg" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.302" />
-                  <Parameter id="GpdEqxq7g0Cxeqkk_1IRaw" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0603" />
-                  <Parameter id="kLuypKPeWk2Pyg5yMyc_xQ" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.126" />
-                  <Parameter id="FOmw6-jMAUi9Q2hAgSocbw" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0044" />
-                  <Parameter id="7fYiX2rHpkCelPp97PW3fw" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0112" />
-                  <Parameter id="MEuw_4EjBEaOi70lKYzcSw" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.41" />
-                  <Parameter id="BsE6lLwXckCw3Tomt8pcgg" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.382" />
-                  <Parameter id="tXgN1hBwaEGEJxS6KHDYpw" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.276" />
-                  <Parameter id="-MKNoU26fEmJuLDfJzN6tg" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.47" />
-                  <Parameter id="dvX7A9LyQEqXYAmHamTbvQ" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0028" />
-                  <Parameter id="3ObnLkCxuEK1gXCscheAbA" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="1.32" />
-                  <DistributedParameter id="Ixz2NtZp0EW24vzsDfvt3Q" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="poMArFaJ506hpaTU85lfrw" mode="Logical" visible="1" displayUnit="l">
-                    <Children>
-                      <Parameter id="4Nu46YNvm0yNYkhG11OzIA" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.504248347732562" displayUnit="l" />
-                      <Parameter id="bUAMff3jcUWX1f9hgp0sUw" name="Mean" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" value="3.0298942433376" displayUnit="l" />
-                      <Parameter id="dE0mbkD240KOXpm1hBp5SA" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" value="0.15149471216688" displayUnit="l" />
-                    </Children>
-                  </DistributedParameter>
-                  <DistributedParameter id="JCfiJJsmakCMOagQ_eOoLQ" name="Specific blood flow rate" description="Blood flow rate normalized to the organ volume" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" formula="QFn_snxVvUiKxy7CrfEx7g" mode="Logical" visible="1" displayUnit="ml/min/100g organ">
-                    <Children>
-                      <Parameter id="qbeKDapx3UCY9FEZnKDYVQ" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" displayUnit="ml/min/100g organ" />
-                      <Parameter id="s011RqEvoUGouWOUQjUE_Q" name="Mean" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" visible="0" canBeVaried="1" value="0.08645" displayUnit="ml/min/100g organ" />
-                      <Parameter id="Uvv2ailmJ0SwfuWZZxfdSw" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0043225" displayUnit="ml/min/100g organ" />
-                    </Children>
-                  </DistributedParameter>
-                  <Container id="WSZy9a4tjEazdIfolnG7tQ" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Skin" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="8v7lGeMPaE6RUwWSBUL5kw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="0fMMkXpA3UWa4lTiNlVFhw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Container id="3uqwYPltekaGZdel4YkaDg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                        <Children>
-                          <Parameter id="5d3dpoimTkKWI2H8Vnchjg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" visible="0" canBeVaried="0" />
-                          <Parameter id="LBd1mmdCp0yYVchgWpKIaw" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                        </Children>
-                      </Container>
-                    </Children>
-                  </Container>
-                  <Container id="pPMIx8esx02hUpNFp0-EDQ" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Skin" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="MBl7NhV88EuNjqGBaAC78A" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="BJ5HX_SLFE2Tjvj-SnWeuQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Container id="nsf-7VPYZU-TQn12eL03ow" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                        <Children>
-                          <Parameter id="dc8XoCFhl0ulsYgk1geFEg" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                          <Parameter id="qmkriSPmZEOsxmqmxjkybw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" visible="0" canBeVaried="0" />
-                        </Children>
-                      </Container>
-                    </Children>
-                  </Container>
-                  <Container id="D2BE9ngGEUuvjzRqxqz8rQ" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Skin" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="g2qK1X--xU6IOBRpBYhJmw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="bJF8g460QUOgevpp5W3-WA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Parameter id="QpTPXPZ5bk-PhsaSMies8A" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_pH_INT" visible="1" canBeVaried="1" />
-                      <Container id="HLMuXSJX70GKJIoks8I0nQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                        <Children>
-                          <Parameter id="axJ3uaP36Ey2g_gL885MMg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_skn" visible="0" canBeVaried="0" />
-                          <Parameter id="aYUWStFwykCK2fHF7bXYyA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                        </Children>
-                      </Container>
-                    </Children>
-                  </Container>
-                  <Container id="3we3dTuwDUm_9NjEJ_wiuA" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Skin" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="lcXh5LyB7028GrHyZ8JNYQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="4WVUuvMrm0KY1fnDnAZNmA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Parameter id="9s3WqR8q-ke6G0s7JS968A" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7" />
-                      <Container id="41R9GUoRKk2WIharI2uVzg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                        <Children>
-                          <Parameter id="ueMBw3u2C0STlpJ_SmsQiA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_skn" visible="0" canBeVaried="0" />
-                          <Parameter id="VyBihUE9LUOj2CSW9w7FTA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                        </Children>
-                      </Container>
-                    </Children>
-                  </Container>
-                </Children>
-              </Container>
-              <Container id="Z74M9J1yLEePHDuzV0hz5A" name="Spleen" description="Spleen" icon="Spleen" mode="Logical" containerType="Organ">
-                <Tags>
-                  <Tag value="Portal Vein Supplying Organ" />
-                  <Tag value="TissueOrgan" />
-                </Tags>
-                <Children>
-                  <Parameter id="ewqn6yCR30OBc6yU3l6qRQ" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="Individual_PKSim.PARAM_Tissue_Weight" visible="0" canBeVaried="1" displayUnit="kg" />
-                  <Parameter id="pg2SVLXvI0ejrmv_1XF_ZQ" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Lymph_flow_rate_Spleen" visible="1" canBeVaried="1" displayUnit="l/min" />
-                  <Parameter id="jvBj9ZZO5k-458bRWTyYCA" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="VascularEndoVolume.VOLUME_VascularEndo_spl" visible="1" canBeVaried="0" displayUnit="l" />
-                  <Parameter id="zukgAkf5m0WVXVax9l-Rhw" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate_Spleen" visible="1" canBeVaried="1" displayUnit="l/min" />
-                  <Parameter id="OnXxSf8OBUalvAU1P8SW5A" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_f_cell" visible="1" canBeVaried="1" />
-                  <Parameter id="HA8toaUBpECQ1LYXPvaJ8g" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Q_from_Qspec" visible="1" canBeVaried="1" displayUnit="l/min" />
-                  <Parameter id="2TV6HvolsUipPkn7wmEdaw" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                  <Parameter id="-1u-VZ1ddUOGkKDwGdjqkg" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.75" />
-                  <Parameter id="HA-XhgOi9US-2CCSkB9jaw" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                  <Parameter id="-cF9ggpgNE6A083Vu7wK8Q" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="9E-08" displayUnit="µm" />
-                  <Parameter id="-QjNc-zxTkyDuuAXE7bbqw" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.8" />
-                  <Parameter id="r1GwVm7-lE2okx1foFlNyw" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="3.3E-07" displayUnit="µm" />
-                  <Parameter id="ckQ1gMtJgUCFI7z7crDr-g" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" visible="1" canBeVaried="1" value="3.88888888888889E-11" displayUnit="ml/min/N" />
-                  <Parameter id="tFWb-Z5u6UuF_s_j1-uCqw" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.016" />
-                  <Parameter id="5A3zrrwZwE6IaVtS0_p5zA" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0201" />
-                  <Parameter id="UxAPhbRL6EWgVIxrNws9Hw" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.33" />
-                  <Parameter id="_tNnY3rE2kWEVyywUy_PtA" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0198" />
-                  <Parameter id="n2Dw84zeQkSDc5ZkoFllig" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.194" />
-                  <Parameter id="d7cM5B2q3UCl_ANobk_sIw" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-                  <Parameter id="E_71fe9xu0i-lLQ3BzQk_A" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.207" />
-                  <Parameter id="xGZBiHNZo02tAfQrNNHQLQ" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.778" />
-                  <Parameter id="VCiY0O0fDkm8_nKei_tChw" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.097" />
-                  <Parameter id="JhKmMpCyxEazLgSPJFo_GQ" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.788" />
-                  <Parameter id="iiqTXiNK7U6YCvybObnAVQ" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.15" />
-                  <Parameter id="hdu3eE__zkiFTrdQQf6axQ" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.006" />
-                  <Parameter id="oF3gAu_OsEiS5hQ2GBvi7Q" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0071" />
-                  <Parameter id="c0s-jC94tECnc8s-eTvEGg" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0107" />
-                  <Parameter id="2y_CXHPGIUy0FkjOh8EjHQ" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0108" />
-                  <Parameter id="KptcQzxpeU-SpeSORXaH4g" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.207" />
-                  <Parameter id="uhB0Z4X1OkKXe8a3cAqj9g" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.23" />
-                  <Parameter id="aMqbSfalEk-6okyQ3_gGwQ" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.355" />
-                  <Parameter id="7eyHie891ESG8pnwbLafRA" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.75" />
-                  <Parameter id="Cog-ILNAnkKjYoQKsmnYVg" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.003" />
-                  <Parameter id="-OaIXooW1EC2Qkhd2YlbQg" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="3.18" />
-                  <DistributedParameter id="sLjQpROATEOKEUmp3VlvYQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="iaDvgrR2PEOQ0wfw8C3SjA" mode="Logical" visible="1" displayUnit="l">
-                    <Children>
-                      <Parameter id="i9KplQC4hEyxp7c-4Igedw" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.344209121610018" displayUnit="l" />
-                      <Parameter id="j0TR_ZLgDUe6jycFIYhKhQ" name="Mean" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" value="0.196099207667264" displayUnit="l" />
-                      <Parameter id="XqLFpmF_rkKUPDRypbQ8nQ" name="GeometricDeviation" description="Geometric standard deviation of LogNormal distribution" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1.5" />
-                    </Children>
-                  </DistributedParameter>
-                  <DistributedParameter id="6PYyPupqpEKnII_kkziBsA" name="Specific blood flow rate" description="Blood flow rate normalized to the organ volume" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" formula="7inVHxlxU0Wq9iXjUEuc7g" mode="Logical" visible="1" displayUnit="ml/min/100g organ">
-                    <Children>
-                      <Parameter id="brgGaqu_40uRe5jIRlVxEQ" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" displayUnit="ml/min/100g organ" />
-                      <Parameter id="yN6i9sgIGk-WT7CRtCnwOQ" name="Mean" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" visible="0" canBeVaried="1" value="0.801125" displayUnit="ml/min/100g organ" />
-                      <Parameter id="MCarajMiDUm5qWsZ-vMgEA" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" visible="0" canBeVaried="1" value="0.04005625" displayUnit="ml/min/100g organ" />
-                    </Children>
-                  </DistributedParameter>
-                  <Container id="K3klVlojjUGDpUNjF0hcjQ" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Portal Vein Supplying Organ" />
-                      <Tag value="Spleen" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="zCMduD9likO3iFkJ-bMdng" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="Bvi6N9MmAUupsM6loHpOzw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Container id="uoQe6zsIlkiKsKwZO_OaXg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                        <Children>
-                          <Parameter id="iNJYc1-ToUiU_HR0tia4WA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                          <Parameter id="-C397MP_Gka9uW5EA9uAIg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" visible="0" canBeVaried="0" />
-                        </Children>
-                      </Container>
-                    </Children>
-                  </Container>
-                  <Container id="UpAw1d6XKEShunReyqujGw" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Portal Vein Supplying Organ" />
-                      <Tag value="Spleen" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="5qkOFNXV4UeNv1NUk7ERHQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="t07-lB1pAk6YiwbGrXUo_w" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Container id="0MJbvgzPzkmxwdcXKVBZ5Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                        <Children>
-                          <Parameter id="veeWaZK5yUqOBJNhkJJcSg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" visible="0" canBeVaried="0" />
-                          <Parameter id="er0Y5ldzXUWT2J2XQTkLGA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                        </Children>
-                      </Container>
-                    </Children>
-                  </Container>
-                  <Container id="n28oBqPjfEuopxshjAxU9g" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Portal Vein Supplying Organ" />
-                      <Tag value="Spleen" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="sr5-lW63okGUoCVaVrD30Q" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="LdnxzNCjoEqdHTdz6LyRvA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Parameter id="cj_Ia1-AQ0O0pQkQhQFP9g" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_pH_INT" visible="1" canBeVaried="1" />
-                      <Container id="y9kYUGZPJU2WvboIgIYAvQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                        <Children>
-                          <Parameter id="rbVGuF4vP0e1s-dnPBL4rQ" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                          <Parameter id="AevMu9WE4Eyw_2qYPWx17A" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_spl" visible="0" canBeVaried="0" />
-                        </Children>
-                      </Container>
-                    </Children>
-                  </Container>
-                  <Container id="7eQFdGd0SE2W5WJgJiG4iQ" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Portal Vein Supplying Organ" />
-                      <Tag value="Spleen" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="ML-HRHo1JE-srCrKushM3A" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="oyXiwSwOrkSsr0GORSjQxg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Parameter id="a1t6kKRUIUKPKVDN6mt3Uw" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7" />
-                      <Container id="Wu5buaE1Vkm3_sGKcgsJuA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                        <Children>
-                          <Parameter id="tG42ut48fUuvZN27qEnsvw" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                          <Parameter id="DRXMhPjgoE-egAQV9adPEg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_spl" visible="0" canBeVaried="0" />
-                        </Children>
-                      </Container>
-                    </Children>
-                  </Container>
-                </Children>
-              </Container>
-              <Container id="We5AyokJIk2r_vmUMQlpkg" name="Saliva" description="Saliva: sampling compartment, not effective for total mass balance" mode="Logical" containerType="Organ">
-                <Children>
-                  <Parameter id="bSrupex8xk-gLmYVZflJRQ" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="Individual_PKSim.PARAM_Tissue_Weight" visible="0" canBeVaried="1" displayUnit="kg" />
-                  <Parameter id="DwXUfn3UQUKmOfs9Blk8cQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="Individual_PKSim.VOLUME_Saliva_Organ" visible="1" canBeVaried="1" displayUnit="l" />
-                  <Parameter id="yADApjnQBEaXcafqoMtCyg" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                  <Parameter id="CUXHIqFqukaTqI7KIz88dg" name="Saliva flow rate" description="Saliva flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" visible="1" canBeVaried="1" value="0.001" displayUnit="l/min" />
-                  <Container id="Y9x7Yqgw4kqi-ZOSL-ZiHA" name="Saliva" description="Saliva: sampling compartment, not effective for total mass balance" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Saliva" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="S5awgNlYFEm653emyfbBxQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_slv_slv" visible="0" canBeVaried="1" displayUnit="l" />
-                      <Parameter id="aSKpp3V6gUiiCOgs4cnFSQ" name="pH (saliva)" description="pH of saliva" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.4" />
-                      <Container id="_iQbJw0GLUmsNmNqi4ysFA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule" />
-                    </Children>
-                  </Container>
-                  <Container id="ByAZ3RX62UmGo8ITt8ggeQ" name="SalivaGland" description="Salivary Gland" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Saliva" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="Q_Zvn1IU_kyudKu7m5iPFA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_slv_slv" visible="0" canBeVaried="1" displayUnit="l" />
-                      <Container id="S7QV4Wnd6ECwFz0k-cofrg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule" />
-                    </Children>
-                  </Container>
-                </Children>
-              </Container>
-            </Children>
-          </Container>
-          <Container id="8FTgFpUOE0uE6YT5jSJfVg" name="Events" description="Parent container for all non-application events" mode="Logical" containerType="Other" />
-        </TopContainers>
-        <NeighborhoodsContainer id="2sHoxZbRZUikbO7_SjXlOg" name="Neighborhoods" description="Neighborhoods" mode="Logical" containerType="Other">
-          <Children>
-            <NeighborhoodBuilder id="HlPlyd1WF0yV9grONC8b4A" name="VenousBlood_pls_VenousBlood_bc" description="Neighborhood between Venous Blood/Plasma and Venous Blood/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="AsKjCr0qtU6a-XJrIrGPTA" secondNeighbor="tLK5A0Qv_EaJTZDJ7FqJQA">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="9K9khaGE_EyJhF2KSoCQ_g" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-                <Parameter id="ualPt6sbwE-oTRIEO0lYAg" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls_Blood_Organ" visible="1" canBeVaried="1" displayUnit="cm²" />
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="TMkqYoRUCkq7X6dQcyD9ww" name="VenousBlood_pls_Lung_pls" description="Neighborhood between Venous Blood/Plasma and Lung/Plasma" mode="Logical" containerType="Other" firstNeighbor="AsKjCr0qtU6a-XJrIrGPTA" secondNeighbor="S9nTwpXAk0mjoLYsPZDHhA">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="R2kt5NYdrEmkkwRc51qTBw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="YlP05iZUFkynESqIdlG6KQ" name="VenousBlood_bc_Lung_bc" description="Neighborhood between Venous Blood/Blood Cells and Lung/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="tLK5A0Qv_EaJTZDJ7FqJQA" secondNeighbor="sntQYIleCUO8SGMqvmOx9A">
-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="odXLIOemgU2iL6vrQGOeVA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="3o5LgF-xvkm4dKEa-YIFdg" name="ArterialBlood_pls_ArterialBlood_bc" description="Neighborhood between Arterial Blood/Plasma and Arterial Blood/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="B0yJEO0-kUqHLgCh369ADQ" secondNeighbor="BuQVS6yXyUaIq4-4XAWfSA">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="IelXODjUlU2OG_gwM1AJZA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-                <Parameter id="GsRpHAKWNE6J_idkfIWv3Q" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls_Blood_Organ" visible="1" canBeVaried="1" displayUnit="cm²" />
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="1RI9wIQ3CEOII4GL8UwL0Q" name="Bone_pls_VenousBlood_pls" description="Neighborhood between Bone/Plasma and Venous Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="5qhBG-74sEmSAgcDLdsKOw" secondNeighbor="AsKjCr0qtU6a-XJrIrGPTA">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="KGBa8_I-GEe_qW4uMa9jsw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="MsgXMUm-NkKzuT696VJtLA" name="Bone_bc_VenousBlood_bc" description="Neighborhood between Bone/Blood Cells and Venous Blood/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="FJ8onNQ3S0m05n8qe_e3lQ" secondNeighbor="tLK5A0Qv_EaJTZDJ7FqJQA">
-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="LlY7WDm1zUqdHeDT9C9qsA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="5CySPdzxJkqKgh70DU6FUQ" name="Bone_pls_Bone_int" description="Neighborhood between Bone/Plasma and Bone/Interstitial" mode="Logical" containerType="Other" firstNeighbor="5qhBG-74sEmSAgcDLdsKOw" secondNeighbor="I4hGcwkmzkmEz3yfrqW3BQ">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Interstitial" />
-              </Tags>
-              <Children>
-                <Container id="HH7yPiYVxkWQjXRsAMEBNw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="Jo-fLxt_1UeRzybLMFtv1A" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" visible="1" canBeVaried="1" value="10" displayUnit="cm/min" />
-                    <Parameter id="eWh_JmR-NEWOkkc72ROsMw" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" visible="1" canBeVaried="1" />
-                  </Children>
-                </Container>
-                <Parameter id="ho89aO7-e0uhCkZg8EMXNA" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" visible="1" canBeVaried="1" displayUnit="cm²" />
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="jfma7yE4ckWMLY8LNpqe8A" name="Bone_pls_Bone_bc" description="Neighborhood between Bone/Plasma and Bone/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="5qhBG-74sEmSAgcDLdsKOw" secondNeighbor="FJ8onNQ3S0m05n8qe_e3lQ">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="wVQHaQtBxE66Pc2PPHf5sw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-                <Parameter id="cvfvoqvMckysWMKVuEQ24A" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" visible="1" canBeVaried="1" displayUnit="cm²" />
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="e47XvXM4b0OsTg5pwWztjQ" name="Bone_int_Bone_cell" description="Neighborhood between Bone/Interstitial and Bone/Intracellular" mode="Logical" containerType="Other" firstNeighbor="I4hGcwkmzkmEz3yfrqW3BQ" secondNeighbor="XBQCWlrnIU6dG_CYS9pmbQ">
-              <Tags>
-                <Tag value="Neighborhood: Interstitial / Intracellular" />
-              </Tags>
-              <Children>
-                <Container id="rKo7X7fAGku6_OIohbgMBQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
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-                <Container id="mkSLQ4DtFEqCHo_iOB8SCg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
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-              <Tags>
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-              <Tags>
-                <Tag value="Neighborhood: Plasma / BloodCells" />
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-                <Container id="0PDapgv_9UaJvsjkCkdJow" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
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-                <Container id="VUkMExalMEWs8jElMP_7eQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
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-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
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-                <Container id="0SxMRLLHTk2pyqr_ppnVUQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
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-                <Tag value="Neighborhood: Plasma / Interstitial" />
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-                <Container id="IRfQl3VyfkGiAwuq8FHRzQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
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-                    <Parameter id="FT0o8mUBCUO3390tn1KcuQ" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" visible="1" canBeVaried="1" />
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-              <Tags>
-                <Tag value="Neighborhood: Plasma / BloodCells" />
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-                <Container id="Fmm93m9qL0OveAV98Ztj8Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-                <Parameter id="HPpn6nI1H0eFOuPUnp1YSg" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" visible="1" canBeVaried="1" displayUnit="cm²" />
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-                <Container id="OgX6VXj0xkqtj5WCOv4pAQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
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-                    <Parameter id="40NNs8rF70O2M3_d4xmjRg" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" visible="0" canBeVaried="1" />
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-                    <Parameter id="QgnAmjI-B0iM7S4ltEztog" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" visible="0" canBeVaried="1" />
-                    <Parameter id="g7Z5Gmo9skexJ9lkvHSlrg" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="0MR6fz1R0k-TOrXdnlZLVQ" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                    <Parameter id="CexwKCwyRUGQXwyZH4OQjQ" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="QjRH5qkfA0utaQqkhm1aaw" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                  </Children>
-                </Container>
-                <Parameter id="ZPgnkg0JbUueyUM5LXOm6A" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_tes" visible="1" canBeVaried="1" displayUnit="cm²" />
-              </Children>
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-            <NeighborhoodBuilder id="ER-Mez7dnkKl3zmiFzkdKg" name="Heart_bc_VenousBlood_bc" description="Neighborhood between Heart/Blood Cells and Venous Blood/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="2ChqB3XlJECSWoT4xWUL4g" secondNeighbor="tLK5A0Qv_EaJTZDJ7FqJQA">
-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="9jL2P2GgsUCcyiqg8nXNwg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="oJLvyws1fU6XRsChwbjHlA" name="Heart_int_Heart_cell" description="Neighborhood between Heart/Interstitial and Heart/Intracellular" mode="Logical" containerType="Other" firstNeighbor="_MdcEmv4h0Gvl-1SRpASXg" secondNeighbor="VCB9eB3pKUCP3lOkO16geQ">
-              <Tags>
-                <Tag value="Neighborhood: Interstitial / Intracellular" />
-              </Tags>
-              <Children>
-                <Container id="CW8QoogHdUu4LSkVHy9dOQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="KFj5ltl1dUyZFV6UQA1yIg" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                    <Parameter id="YJQ-VoxBlk-qdgTdyqLgPA" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                    <Parameter id="wrf7q1FIyEeR3qo1pDrp8A" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="eo4Jm15480GTJPH8G0CsoQ" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="pZ4_exhdokSu1ZjRZLgH3Q" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" visible="0" canBeVaried="1" />
-                    <Parameter id="RpbInYorrUqNv3l9ydSsYQ" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" visible="0" canBeVaried="1" />
-                    <Parameter id="5AP9cJCFEk2hF1fPKPgzjQ" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" visible="1" canBeVaried="1" />
-                    <Parameter id="XXvH-WUXYkerX8r8JKI4Nw" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" visible="0" canBeVaried="1" />
-                  </Children>
-                </Container>
-                <Parameter id="ZgSvQ9Q22kGr8JNdws7BzA" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_hrt" visible="1" canBeVaried="1" displayUnit="cm²" />
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-            <NeighborhoodBuilder id="KdQAKaECkUa9MYVT8p764w" name="Heart_pls_Heart_bc" description="Neighborhood between Heart/Plasma and Heart/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="8FF9S5dtNES_fI7J-tqAmQ" secondNeighbor="2ChqB3XlJECSWoT4xWUL4g">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="4Rjm51r24EKjPjzcgSFf6w" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-                <Parameter id="IpP_uZUY5kuDDmJoVfFZhA" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" visible="1" canBeVaried="1" displayUnit="cm²" />
-              </Children>
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-            <NeighborhoodBuilder id="8i9hsc-P9kuhwDrLmdgkzQ" name="Heart_pls_Heart_int" description="Neighborhood between Heart/Plasma and Heart/Interstitial" mode="Logical" containerType="Other" firstNeighbor="8FF9S5dtNES_fI7J-tqAmQ" secondNeighbor="_MdcEmv4h0Gvl-1SRpASXg">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Interstitial" />
-              </Tags>
-              <Children>
-                <Container id="4WdkoDciX02yK7jDk9QkHA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="Xe_vsd9g5k-5YSC13r5LnQ" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" visible="1" canBeVaried="1" value="10" displayUnit="cm/min" />
-                    <Parameter id="FAu32f1ir0yPmrSHJb-jAw" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" visible="1" canBeVaried="1" />
-                  </Children>
-                </Container>
-                <Parameter id="RqKPrvbC6k67RghWw5gozg" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" visible="1" canBeVaried="1" displayUnit="cm²" />
-              </Children>
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-            <NeighborhoodBuilder id="KzzCIHb4KEuKmzk2iieYqw" name="Heart_pls_VenousBlood_pls" description="Neighborhood between Heart/Plasma and Venous Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="8FF9S5dtNES_fI7J-tqAmQ" secondNeighbor="AsKjCr0qtU6a-XJrIrGPTA">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
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-              <Children>
-                <Container id="KAXyUgyHSUaCruXA4oZmpg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="m-En-jMTTU-t2SrJUd3HvA" name="Kidney_bc_VenousBlood_bc" description="Neighborhood between Kidney/Blood Cells and Venous Blood/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="8zPkGeGmU0OEOAd4v6wLwA" secondNeighbor="tLK5A0Qv_EaJTZDJ7FqJQA">
-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="OHcP2gn03k2XitGw_F3jEg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="-C5WLXg0CEi0ReMEmGPFkA" name="Kidney_int_Kidney_cell" description="Neighborhood between Kidney/Interstitial and Kidney/Intracellular" mode="Logical" containerType="Other" firstNeighbor="Lowod1S6EUOQfh9G0nlt1A" secondNeighbor="eLf8CEl_NUi-dMAposbfrA">
-              <Tags>
-                <Tag value="Neighborhood: Interstitial / Intracellular" />
-              </Tags>
-              <Children>
-                <Container id="ABMS2EIuCkyUqE-q9Mt9qQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="MhhM9ctbIka8Q7lkXv83RA" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" visible="0" canBeVaried="1" />
-                    <Parameter id="8rsJK98QvkmlLqixsZ7EcQ" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                    <Parameter id="dXoBM-5M7E2yzEHw6268iw" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                    <Parameter id="qtRcPeFZpUamMWupvHbCQQ" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="DkH8S4GbrEqxxf7w4OF1TA" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" visible="0" canBeVaried="1" />
-                    <Parameter id="2v6o6KCrJk-_aF7DTGwXfw" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" visible="1" canBeVaried="1" />
-                    <Parameter id="xvC1_l3S90a6BzPESQZ3JA" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" visible="0" canBeVaried="1" />
-                    <Parameter id="y6r7HXKiIkCYIMBEBLLAeA" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" visible="0" canBeVaried="1" displayUnit="l/min" />
-                  </Children>
-                </Container>
-                <Parameter id="2uciSJRaW0WbJAGIl8RxYg" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_kid" visible="1" canBeVaried="1" displayUnit="cm²" />
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="0I_6S4CTHk6HhKgoiLc1Dw" name="Kidney_cell_Kidney_ur" description="Neighborhood between Kidney/Intracellular and Kidney/Urine" mode="Logical" containerType="Other" firstNeighbor="eLf8CEl_NUi-dMAposbfrA" secondNeighbor="o6ozB8VQSky3KivzfiFkuQ">
-              <Tags>
-                <Tag value="Neighborhood: Intracellular / Urine" />
-              </Tags>
-              <Children>
-                <Container id="A02tFKrqH0SfxUEIrASTEQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="2O4MOCCBuUGGtFpeN6bpkw" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_water_cell_Kidney" visible="0" canBeVaried="1" />
-                  </Children>
-                </Container>
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="5ba1q8dwN0GJgN6a39rHHw" name="Kidney_pls_Kidney_bc" description="Neighborhood between Kidney/Plasma and Kidney/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="vNliK8ccZ0mhuF90e6m6Sw" secondNeighbor="8zPkGeGmU0OEOAd4v6wLwA">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="zx22k_8xzEWXgBD8mVJ3Tg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-                <Parameter id="_0ds6Ghi50GflliaLKPG-w" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" visible="1" canBeVaried="1" displayUnit="cm²" />
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="-Gjmn5DaLE2P8EdUf5mM-Q" name="Kidney_pls_Kidney_int" description="Neighborhood between Kidney/Plasma and Kidney/Interstitial" mode="Logical" containerType="Other" firstNeighbor="vNliK8ccZ0mhuF90e6m6Sw" secondNeighbor="Lowod1S6EUOQfh9G0nlt1A">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Interstitial" />
-              </Tags>
-              <Children>
-                <Container id="o8ddjkg1kUW3bFxQREv9BQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="HoEbThd_8UWw16uYyw5pGA" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" visible="1" canBeVaried="1" value="10" displayUnit="cm/min" />
-                    <Parameter id="kP6z1evQYEWvfL0eEx0J0g" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" visible="1" canBeVaried="1" />
-                  </Children>
-                </Container>
-                <Parameter id="pqaRKdynz0u1380gDWBOAQ" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" visible="1" canBeVaried="1" displayUnit="cm²" />
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="V6xp45iaJE-VGxUxjPsX7w" name="Kidney_pls_Kidney_ur" description="Neighborhood between Kidney/Plasma and Kidney/Urine" mode="Logical" containerType="Other" firstNeighbor="vNliK8ccZ0mhuF90e6m6Sw" secondNeighbor="o6ozB8VQSky3KivzfiFkuQ">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Urine" />
-              </Tags>
-              <Children>
-                <Container id="pG-w2ivSiUCqXlvFrPDrMA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="ZcK8xCp5MU-Dc_onXjqnLg" name="UpperJejunum_pls_PortalVein_pls" description="Neighborhood between Upper Jejunum/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="BfP4xKdBX0SaUMpMCDXvbg" secondNeighbor="-btXNr8mOEG_8ZCjsspLow">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="Pum-q89AukW0figBf6w6CA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="ZMefrTJilE2NNAQAjUBOng" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPvePlasma" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  </Children>
-                </Container>
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="wfLtidEgok-oujKmwQOA1A" name="Lumen_uje_UpperJejunum_cell" description="Neighborhood between Lumen/Upper Jejunum and Mucosa/Upper Jejunum/Intracellular" mode="Logical" containerType="Other" firstNeighbor="yZg5exSq8EiErExr7X9h7A" secondNeighbor="kUFeS_kjtUW66GnJH4ZzKg">
-              <Tags>
-                <Tag value="Neighborhood: UpperJejunum / Intracellular" />
-              </Tags>
-              <Children>
-                <Container id="2lQw_8ZmaU6P7bk7YxJr9w" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="cghQAIHz8E6NNW61UxW3sg" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="l4Z-gbxiVUyZwcTyMj742w" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="HKaedLawfECfYOE_zSgKfA" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K6" visible="0" canBeVaried="0" />
-                    <Parameter id="lCtpf2mP-Ea2mhukW49TzA" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K5" visible="0" canBeVaried="0" />
-                    <Parameter id="4Vugm3GJN0eMvVcVKbAjRg" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_DrugAbsorption_trans" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="KgD7p8OoVUe6Bh8FswPhNw" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_cell_lum_factor" visible="0" canBeVaried="0" />
-                    <Parameter id="kUHVUCdpQUGiO3YFDZnk3Q" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_lum_cell_factor" visible="0" canBeVaried="0" />
-                    <Parameter id="q0QVei_ceUGiry9FXLufMw" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Lumen_PKSim.PARAM_K_cell_pls_UpperJejunum" visible="0" canBeVaried="0" />
-                    <Parameter id="mZo5Ws8NW0yHp1j0gNEhyw" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_UpperJejunum" visible="0" canBeVaried="1" />
-                    <Parameter id="WtN8iGMyFECXM5A8XwJL9A" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F1" visible="0" canBeVaried="0" />
-                    <Parameter id="OZsUePWtYkWAlDRsS5mQ9Q" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F2" visible="0" canBeVaried="0" />
-                    <Parameter id="Lw1jwcsfjkuVeyS87BChmw" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F3" visible="0" canBeVaried="0" />
-                    <Parameter id="CjE2AEK0nEaEA2Whbm5RFw" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K1" visible="0" canBeVaried="0" />
-                    <Parameter id="HRYNtkoJYUKukxEoVhKVcg" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K2" visible="0" canBeVaried="0" />
-                    <Parameter id="LV8kU90eKU-jl3m_WsKP4g" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K8" visible="0" canBeVaried="0" />
-                    <Parameter id="iop906MAAEGgk7FkFl_pWQ" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K4" visible="0" canBeVaried="0" />
-                    <Parameter id="92SvCK4f3EKt3F1eskOpNw" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K7" visible="0" canBeVaried="0" />
-                    <Parameter id="FoagA8EZD0mlio39gehIHw" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K6" visible="0" canBeVaried="0" />
-                    <Parameter id="h1KJISJJHUKkrIqfKxojmw" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K7" visible="0" canBeVaried="0" />
-                    <Parameter id="Uk7eq5T9skihd3Jx-uJ6ng" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K8" visible="0" canBeVaried="0" />
-                    <Parameter id="3XWNnUFLqk6PCqwobp1DEg" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F1" visible="0" canBeVaried="0" />
-                    <Parameter id="PkGmBs9MxkK-Zk3ZuEXjOA" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F2" visible="0" canBeVaried="0" />
-                    <Parameter id="0nle1JhH7UaK4Mlj3tm3tA" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F3" visible="0" canBeVaried="0" />
-                    <Parameter id="ZM-ZLyV84kq0VPZvYSzvtA" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K1" visible="0" canBeVaried="0" />
-                    <Parameter id="hxAj7dzKx0S1C5_Wv0uiog" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K2" visible="0" canBeVaried="0" />
-                    <Parameter id="GWPhEtEWJUObXBAmGiRbQQ" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K3" visible="0" canBeVaried="0" />
-                    <Parameter id="LMxncQf8kUiR4HO7u1Idyw" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K4" visible="0" canBeVaried="0" />
-                    <Parameter id="ESt_aJc5s0KFRw-muxtULw" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K5" visible="0" canBeVaried="0" />
-                    <Parameter id="pyBpaam01kqgnHfA8ScVCg" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K3" visible="0" canBeVaried="0" />
-                  </Children>
-                </Container>
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="gFZG4bXDnk2ayskbCxF7Lw" name="Lumen_uje_UpperJejunum_pls" description="Neighborhood between Lumen/Upper Jejunum and Mucosa/Upper Jejunum/Plasma" mode="Logical" containerType="Other" firstNeighbor="yZg5exSq8EiErExr7X9h7A" secondNeighbor="BfP4xKdBX0SaUMpMCDXvbg">
-              <Tags>
-                <Tag value="Neighborhood: UpperJejunum / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="i3r5fSECoUSPGxU_UNyTAQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="kpo4qaSgrEuYCE2BqSJGbg" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_DrugAbsorption_para" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="jbQZKJrMFkmFMrkiAj-p7g" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="dmbUfgKNqkuhXh0u237ltQ" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  </Children>
-                </Container>
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="da4aMbuuxEOuomJOpKBisg" name="UpperJejunum_bc_PortalVein_bc" description="Neighborhood between Upper Jejunum/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="Ej30rRxCREi_lFbIacWhBg" secondNeighbor="ghMacG-81kSUPN5wkgPsnA">
-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="7r1bla8ahkex9__-4YG6IQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="GfBgsNfvKUqgA5TPmUomYg" name="Mass transfer rate (mucosa to portal vein blood cells)" description="Mass transfer rate (mucosa to portal vein blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPveBloodCells" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  </Children>
-                </Container>
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="2M2dTvKZUkCAI9nHyTSyqw" name="Kidney_pls_VenousBlood_pls" description="Neighborhood between Kidney/Plasma and Venous Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="vNliK8ccZ0mhuF90e6m6Sw" secondNeighbor="AsKjCr0qtU6a-XJrIrGPTA">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="69dQrQu1qkmMfOoDf14t4Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="CqeMRXubhUCZe_13INWPyA" name="Lumen_uil_Lumen_lil" description="Neighborhood between Lumen/Upper Ileum and Lumen/Lower Ileum" mode="Logical" containerType="Other" firstNeighbor="GllsaRsHZUOo1T5JiPknaA" secondNeighbor="vCPS2yMfPkKIhDcs0uJgFQ">
-              <Tags>
-                <Tag value="Neighborhood: UpperIleum / LowerIleum" />
-              </Tags>
-              <Children>
-                <Container id="DtfoWXyWW0S5ubdh0f85BA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="fHK4MWhsKEuFbpOct2OXnA" name="Lumen_sto_Lumen_duo" description="Neighborhood between Lumen/Stomach and Lumen/Duodenum" mode="Logical" containerType="Other" firstNeighbor="UmGxOEHQ7kGDntzb_Y39tw" secondNeighbor="B2SJL0T_506x1Wlk3TTamQ">
-              <Tags>
-                <Tag value="Neighborhood: Stomach / Duodenum" />
-              </Tags>
-              <Children>
-                <Container id="83VR44eHUUeDU7v2q-Ibww" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="uO7nFddRYUeDMPUP9-eRcA" name="Oral mass absorbed" description="Oral mass absorbed from Lumen into mucosa" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" formula="Lumen_PKSim.PARAM_OralMassAbsorbed" visible="0" canBeVaried="0" displayUnit="µmol" />
-                  </Children>
-                </Container>
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="rZsve4MWIECfB2c0ur1DkQ" name="Lumen_duo_Lumen_uje" description="Neighborhood between Lumen/Duodenum and Lumen/Upper Jejunum" mode="Logical" containerType="Other" firstNeighbor="B2SJL0T_506x1Wlk3TTamQ" secondNeighbor="yZg5exSq8EiErExr7X9h7A">
-              <Tags>
-                <Tag value="Neighborhood: Duodenum / UpperJejunum" />
-              </Tags>
-              <Children>
-                <Container id="n0jjdwJvb0alx2L06W5YiQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="1suiObw0gEOGgfieHI7fQw" name="Lumen_lje_Lumen_uil" description="Neighborhood between Lumen/Lower Jejunum and Lumen/Upper Ileum" mode="Logical" containerType="Other" firstNeighbor="ZDiugimqaEynDJbV3Eje2g" secondNeighbor="GllsaRsHZUOo1T5JiPknaA">
-              <Tags>
-                <Tag value="Neighborhood: LowerJejunum / UpperIleum" />
-              </Tags>
-              <Children>
-                <Container id="17hJF6DGu0ebn4NANDbqKA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="umn1JjXWxECjDpYL73yXSQ" name="LowerJejunum_bc_PortalVein_bc" description="Neighborhood between Lower Jejunum/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="JvhcU5G9sESOfI0HQ9iySg" secondNeighbor="ghMacG-81kSUPN5wkgPsnA">
-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="2LX37BIB2Eaf3M_DSXWMCQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="95210DqeZU26uDLDPVP8YA" name="Mass transfer rate (mucosa to portal vein blood cells)" description="Mass transfer rate (mucosa to portal vein blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPveBloodCells" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  </Children>
-                </Container>
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="Oez18RfCBkmtbT7XFNDlXg" name="Lumen_lil_Lumen_cae" description="Neighborhood between Lumen/Lower Ileum and Lumen/Cecum" mode="Logical" containerType="Other" firstNeighbor="vCPS2yMfPkKIhDcs0uJgFQ" secondNeighbor="sk41NH_8KEi_nNbtDlGvFA">
-              <Tags>
-                <Tag value="Neighborhood: LowerIleum / Caecum" />
-              </Tags>
-              <Children>
-                <Container id="VNA1vEs7oEK-F6frGkWQhw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="E6Bneiygb0imugiHDJJYDA" name="Lumen_rect_Lumen_fec" description="Neighborhood between Lumen/Rectum and Lumen/Feces" mode="Logical" containerType="Other" firstNeighbor="tl7DiBQWEUGwcvPUXLf68w" secondNeighbor="bhSAzpl7HkaX9dPtBlqhGQ">
-              <Tags>
-                <Tag value="Neighborhood: Rectum / Feces" />
-              </Tags>
-              <Children>
-                <Container id="wLjpHgk4x0WyAIDWYainpg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="0BarMzds00y8D-PhEaW16w" name="Lumen_colasc_Lumen_coltrans" description="Neighborhood between Lumen/Colon Ascendens and Lumen/Colon Transversum" mode="Logical" containerType="Other" firstNeighbor="xYyLHo4Vhk6D6RJrPpFicA" secondNeighbor="EhWe8Xqa6EKqp-YjJgQUiw">
-              <Tags>
-                <Tag value="Neighborhood: ColonAscendens / ColonTransversum" />
-              </Tags>
-              <Children>
-                <Container id="0fohY052rkeTRpbEg6_klw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="-ByF8Ho_B0izlH2AyQFvLA" name="Lumen_coltrans_Lumen_coldesc" description="Neighborhood between Lumen/Colon Transversum and Lumen/Colon Descendens" mode="Logical" containerType="Other" firstNeighbor="EhWe8Xqa6EKqp-YjJgQUiw" secondNeighbor="TQQ1m1iJG0CQmvlfvaPkuA">
-              <Tags>
-                <Tag value="Neighborhood: ColonTransversum / ColonDescendens" />
-              </Tags>
-              <Children>
-                <Container id="LXcWeAjZD0K6kpncCUQVIg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="DORJxgo19EKj_4vGMPI9Nw" name="Lumen_coldesc_Lumen_colsigm" description="Neighborhood between Lumen/Colon Descendens and Lumen/Colon Sigmoid" mode="Logical" containerType="Other" firstNeighbor="TQQ1m1iJG0CQmvlfvaPkuA" secondNeighbor="pXPUliiKakqWhra3psEI6A">
-              <Tags>
-                <Tag value="Neighborhood: ColonDescendens / ColonSigmoid" />
-              </Tags>
-              <Children>
-                <Container id="fuSRswCUMU-nbYO7gDYKhw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="YgUHYZN0eky5ZRyyaSJ3yw" name="Lumen_colsigm_Lumen_rect" description="Neighborhood between Lumen/Colon Sigmoid and Lumen/Rectum" mode="Logical" containerType="Other" firstNeighbor="pXPUliiKakqWhra3psEI6A" secondNeighbor="tl7DiBQWEUGwcvPUXLf68w">
-              <Tags>
-                <Tag value="Neighborhood: ColonSigmoid / Rectum" />
-              </Tags>
-              <Children>
-                <Container id="LsyjstcR2UiVW_dCfsu90g" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="Jx3VDgIKGkCdYwGqbvqNFA" name="Lumen_uje_Lumen_lje" description="Neighborhood between Lumen/Upper Jejunum and Lumen/Lower Jejunum" mode="Logical" containerType="Other" firstNeighbor="yZg5exSq8EiErExr7X9h7A" secondNeighbor="ZDiugimqaEynDJbV3Eje2g">
-              <Tags>
-                <Tag value="Neighborhood: UpperJejunum / LowerJejunum" />
-              </Tags>
-              <Children>
-                <Container id="6iuuquHwKE-p7RUMTJSujw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="6NpwyImPWke2jphPRssxyw" name="Lumen_cae_Lumen_colasc" description="Neighborhood between Lumen/Cecum and Lumen/Colon Ascendens" mode="Logical" containerType="Other" firstNeighbor="sk41NH_8KEi_nNbtDlGvFA" secondNeighbor="xYyLHo4Vhk6D6RJrPpFicA">
-              <Tags>
-                <Tag value="Neighborhood: Caecum / ColonAscendens" />
-              </Tags>
-              <Children>
-                <Container id="UJRQKVvp4Ui09oE3-vWI6A" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="dLhqv-IB2k-BgRhyzxFw0g" name="Lumen_lje_LowerJejunum_pls" description="Neighborhood between Lumen/Lower Jejunum and Mucosa/Lower Jejunum/Plasma" mode="Logical" containerType="Other" firstNeighbor="ZDiugimqaEynDJbV3Eje2g" secondNeighbor="1XxBZvONAEWWEWN1gOg4VQ">
-              <Tags>
-                <Tag value="Neighborhood: LowerJejunum / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="AeYHzdTMCEOMu6irPjnUtA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="jEUY3mLp9Ue1-Gl2YQKplQ" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_DrugAbsorption_para" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="88QbXc30ykSkJmrvUri7dQ" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="qunkfu1AWU-AalCReQx-yA" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  </Children>
-                </Container>
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="-0Hsw-q1Z0exIiP46uQoBg" name="Lumen_lje_LowerJejunum_cell" description="Neighborhood between Lumen/Lower Jejunum and Mucosa/Lower Jejunum/Intracellular" mode="Logical" containerType="Other" firstNeighbor="ZDiugimqaEynDJbV3Eje2g" secondNeighbor="H45QSpDHZU6_rrF8B6S3IQ">
-              <Tags>
-                <Tag value="Neighborhood: LowerJejunum / Intracellular" />
-              </Tags>
-              <Children>
-                <Container id="eF8DNoIfS0280rmXVNsMSQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="mazT_buqn0e9QYs85kdaWg" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_DrugAbsorption_trans" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="_05iY5K0JUCSL8YnnSIqKQ" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K5" visible="0" canBeVaried="0" />
-                    <Parameter id="9O2yflLuHkqkr2oIMbIW_w" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_cell_lum_factor" visible="0" canBeVaried="0" />
-                    <Parameter id="lKxFjRopFEy6bp8jkW8J4Q" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_lum_cell_factor" visible="0" canBeVaried="0" />
-                    <Parameter id="zMMa5aDxk0Wp2cEvvMyw0g" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Lumen_PKSim.PARAM_K_cell_pls_LowerJejunum" visible="0" canBeVaried="0" />
-                    <Parameter id="KyOoHKq_HU2F3M2OWpXpug" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_LowerJejunum" visible="0" canBeVaried="1" />
-                    <Parameter id="RhQJW-FWxECXNlaaWo5qlQ" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F1" visible="0" canBeVaried="0" />
-                    <Parameter id="CXSvNqsr_0et-ojQr2iwog" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F2" visible="0" canBeVaried="0" />
-                    <Parameter id="vW6IbucPBUC2YVackZj3aw" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F3" visible="0" canBeVaried="0" />
-                    <Parameter id="HtzwOXyvt0i2mXeLElXcag" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K1" visible="0" canBeVaried="0" />
-                    <Parameter id="6L9ENBdyKEmv_oGjk0HnBg" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K2" visible="0" canBeVaried="0" />
-                    <Parameter id="iDbjTUlodkGDUNeUeQnThg" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K3" visible="0" canBeVaried="0" />
-                    <Parameter id="LP_8iQhJk0G_ZAQFfOxXjg" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K6" visible="0" canBeVaried="0" />
-                    <Parameter id="dznn1tGxT0-xzd9fc5pTJg" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K4" visible="0" canBeVaried="0" />
-                    <Parameter id="yEIkYhMGN02Siq04IFqwQQ" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="xbNrB9momkGT6dAajGV1EA" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K7" visible="0" canBeVaried="0" />
-                    <Parameter id="f2tBtA5aSUOIksbzTJQD4Q" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K8" visible="0" canBeVaried="0" />
-                    <Parameter id="P0kfxhfimkOFqI1lDOi8KA" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F1" visible="0" canBeVaried="0" />
-                    <Parameter id="M5KlA9z49Uu513w1b6oidg" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F2" visible="0" canBeVaried="0" />
-                    <Parameter id="NhTjz8S-LEKfSf20jwv-IA" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F3" visible="0" canBeVaried="0" />
-                    <Parameter id="2UNa2Pi-jEmxrmitsOSTaQ" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K1" visible="0" canBeVaried="0" />
-                    <Parameter id="0Mn4NSSvtkKNgHdCyuEPDQ" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K2" visible="0" canBeVaried="0" />
-                    <Parameter id="8lAM9SbC_EeQFfTZUG2ZLw" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K3" visible="0" canBeVaried="0" />
-                    <Parameter id="EhDqUtChpUuwMIbPu9-fIw" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K4" visible="0" canBeVaried="0" />
-                    <Parameter id="8II0wUjpekWPWHORvJkmZA" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K5" visible="0" canBeVaried="0" />
-                    <Parameter id="k9Bax-j0F0KKQL14Rhp6zw" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K6" visible="0" canBeVaried="0" />
-                    <Parameter id="iiaRsC28AUamzOuT9la0-w" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K8" visible="0" canBeVaried="0" />
-                    <Parameter id="uaDsiB0qbUKL5WLCr3-s4Q" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="EP3qiYJog0q5qNJARtgf1A" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K7" visible="0" canBeVaried="0" />
-                  </Children>
-                </Container>
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="jXI2DJQCskW6sZesS_K8GA" name="LowerJejunum_pls_PortalVein_pls" description="Neighborhood between Lower Jejunum/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="1XxBZvONAEWWEWN1gOg4VQ" secondNeighbor="-btXNr8mOEG_8ZCjsspLow">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="SmtONG8KhE-wDQXTWvQFww" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="m0Ufvz-hKUKiKiKLkCzBkA" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPvePlasma" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  </Children>
-                </Container>
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="LkrZpG0wPUCiWHjBIBJv9A" name="UpperIleum_pls_PortalVein_pls" description="Neighborhood between Upper Ileum/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="agEz-d8UnU2AlENh6qiY5A" secondNeighbor="-btXNr8mOEG_8ZCjsspLow">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="CWTNvgiiKku8H1pReH6ZVg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="waQ4tg5F90mzgTtkFGdwuA" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPvePlasma" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  </Children>
-                </Container>
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="x_Mx63CLC02BFZsukkRq1A" name="Stomach_pls_Stomach_bc" description="Neighborhood between Stomach/Plasma and Stomach/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="wcVwGWqUikGrxah1-6Vx6A" secondNeighbor="ZsgRGsl2Ika6nIUVelD34g">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="DaUooU_LYECQp90ukm0HXQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-                <Parameter id="b7_Bsn5DSkmKSFsKB1d1ug" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" visible="1" canBeVaried="1" displayUnit="cm²" />
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="SdylVoAiHEOXG4lNHXA05w" name="Stomach_pls_Stomach_int" description="Neighborhood between Stomach/Plasma and Stomach/Interstitial" mode="Logical" containerType="Other" firstNeighbor="wcVwGWqUikGrxah1-6Vx6A" secondNeighbor="pkdR9CiDHEq7nh4GTlLyVA">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Interstitial" />
-              </Tags>
-              <Children>
-                <Container id="9V-stqN1SUODxFR0QbW5vg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="EvXb4XhDkUa3tfW3vYXVbw" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" visible="1" canBeVaried="1" />
-                    <Parameter id="wsRGT_Rtsk-ifM-z8Abeyg" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" visible="1" canBeVaried="1" value="10" displayUnit="cm/min" />
-                  </Children>
-                </Container>
-                <Parameter id="hPilTrXklUOKHECYizVZZw" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" visible="1" canBeVaried="1" displayUnit="cm²" />
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="jQ9ZntXk3E2A8CT80KreOg" name="Stomach_pls_PortalVein_pls" description="Neighborhood between Stomach/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="wcVwGWqUikGrxah1-6Vx6A" secondNeighbor="-btXNr8mOEG_8ZCjsspLow">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="jH9fuO5R1kWw6DeNNOyw2w" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="YSE6NheLNU6wXEnn_QAC0w" name="Stomach_bc_PortalVein_bc" description="Neighborhood between Stomach/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="ZsgRGsl2Ika6nIUVelD34g" secondNeighbor="ghMacG-81kSUPN5wkgPsnA">
-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="pSaOwkvMAUGTtAMaTtY0xw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="xeXqTnRf5EerJCbDxnDZxA" name="Stomach_int_Stomach_cell" description="Neighborhood between Stomach/Interstitial and Stomach/Intracellular" mode="Logical" containerType="Other" firstNeighbor="pkdR9CiDHEq7nh4GTlLyVA" secondNeighbor="Mur3m3tL10Ga-Q6Mn5phPg">
-              <Tags>
-                <Tag value="Neighborhood: Interstitial / Intracellular" />
-              </Tags>
-              <Children>
-                <Container id="1hh_eWj1m0uJoPpDPFQE1g" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="xmGG2gaikEiE7Lu37SME2Q" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                    <Parameter id="LBD0DmKVC0qv1QVqv_MeIQ" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                    <Parameter id="BkhdjZC-oE2HPCDSD1K3_Q" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="0pUdLYzBJU6DhPGiymfuYw" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="RWF8XzhP-U2UNWBTTxdoag" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" visible="0" canBeVaried="1" />
-                    <Parameter id="ajXtcO7dgEi1TS-GbI-Zkw" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" visible="0" canBeVaried="1" />
-                    <Parameter id="zHWUuu__-0ar8LABFGZumQ" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" visible="1" canBeVaried="1" />
-                    <Parameter id="WcCn5Mt0MUGjq1z5uHr3Rw" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" visible="0" canBeVaried="1" />
-                  </Children>
-                </Container>
-                <Parameter id="3v2gHzTMNkKXzI_xInPnkA" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_sto" visible="1" canBeVaried="1" displayUnit="cm²" />
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="YEP93NNp5EWzVnNDJO0kZg" name="Lumen_uil_UpperIleum_cell" description="Neighborhood between Lumen/Upper Ileum and Mucosa/Upper Ileum/Intracellular" mode="Logical" containerType="Other" firstNeighbor="GllsaRsHZUOo1T5JiPknaA" secondNeighbor="Ei9kUV8Ht0yP_sgNxLtolg">
-              <Tags>
-                <Tag value="Neighborhood: UpperIleum / Intracellular" />
-              </Tags>
-              <Children>
-                <Container id="C-GlFMhDtU6En4CT_6OZGw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="_NGDCcfCpEqMU5ZZy-nXwg" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="EqgSH6B0d02Xe5oGGYgw4g" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="RO2LgOs_IkyaeDXbN5giaQ" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K8" visible="0" canBeVaried="0" />
-                    <Parameter id="FKnEXTvys0eJGan8UoM9LA" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_lum_cell_factor" visible="0" canBeVaried="0" />
-                    <Parameter id="noui1PIq2UaDQMsDZhWcgA" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Lumen_PKSim.PARAM_K_cell_pls_UpperIleum" visible="0" canBeVaried="0" />
-                    <Parameter id="9lrD9gSFNEOMmhhmIOk9_A" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_UpperIleum" visible="0" canBeVaried="1" />
-                    <Parameter id="rQ2DpVZJUEOowkTjN8yZeQ" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F1" visible="0" canBeVaried="0" />
-                    <Parameter id="2xsNoLPxAkGtTHUstiGqmw" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F2" visible="0" canBeVaried="0" />
-                    <Parameter id="nc7-DZpHdkSioLkqcLyg6A" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F3" visible="0" canBeVaried="0" />
-                    <Parameter id="E6bwfQpyBU60JKpZpPtmkg" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K1" visible="0" canBeVaried="0" />
-                    <Parameter id="2L_oFq9rS0yOT0Ou7WdYMg" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K2" visible="0" canBeVaried="0" />
-                    <Parameter id="AuS60CgYpkmYsG-5FyIccA" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K3" visible="0" canBeVaried="0" />
-                    <Parameter id="6u26OlZjkkiV_b-WFuUK3Q" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K4" visible="0" canBeVaried="0" />
-                    <Parameter id="TSAlzgIfYkeIBZpRvjAHEA" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K5" visible="0" canBeVaried="0" />
-                    <Parameter id="2mJt-c1oqkGfO-vKfyfigQ" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K7" visible="0" canBeVaried="0" />
-                    <Parameter id="VgExCFiHR0O6nuGBrZdgfA" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F1" visible="0" canBeVaried="0" />
-                    <Parameter id="s1k37O9x5Uma2GjY1M63Iw" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F2" visible="0" canBeVaried="0" />
-                    <Parameter id="o2mwJoK0LU6iYtTPtF05gg" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F3" visible="0" canBeVaried="0" />
-                    <Parameter id="XfN7Mguzd0WN85ypWO2QXw" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K1" visible="0" canBeVaried="0" />
-                    <Parameter id="5yDC15WbPUe6I-DnvGRD1Q" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K2" visible="0" canBeVaried="0" />
-                    <Parameter id="K2KTQIRTQEacbyIBybjB8w" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K3" visible="0" canBeVaried="0" />
-                    <Parameter id="Fp12hickTE6NYeBQry96tA" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K4" visible="0" canBeVaried="0" />
-                    <Parameter id="oS_9yt67VUql0tpiUKsbBw" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K5" visible="0" canBeVaried="0" />
-                    <Parameter id="2_SB8bs84U-T6mnW1NTs1A" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K6" visible="0" canBeVaried="0" />
-                    <Parameter id="y-2x-JaB0EuNLFMGKQn09g" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K7" visible="0" canBeVaried="0" />
-                    <Parameter id="8vvInMb_FU6BUqcfCrsTxA" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K8" visible="0" canBeVaried="0" />
-                    <Parameter id="N-C4B1Sh9U2fz1Lw0C-Z8g" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K6" visible="0" canBeVaried="0" />
-                    <Parameter id="7LLL09c7gkKKjwNAnOHShQ" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_cell_lum_factor" visible="0" canBeVaried="0" />
-                    <Parameter id="JIjbr4SXZUWgCuR9zw6URw" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_DrugAbsorption_trans" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  </Children>
-                </Container>
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="0Xjl6YCcnUmPk5h_e4B5Zg" name="UpperIleum_bc_PortalVein_bc" description="Neighborhood between Upper Ileum/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="o2sI8fS0SkSgY4brbhcmyA" secondNeighbor="ghMacG-81kSUPN5wkgPsnA">
-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="k3bbBfn6g0iOnWvpuw0wPg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="tj88thh6S0-fyUr7GXj3WQ" name="Mass transfer rate (mucosa to portal vein blood cells)" description="Mass transfer rate (mucosa to portal vein blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPveBloodCells" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  </Children>
-                </Container>
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="RQ7vT23n2E-GM3oWwz7zAA" name="Lumen_uil_UpperIleum_pls" description="Neighborhood between Lumen/Upper Ileum and Mucosa/Upper Ileum/Plasma" mode="Logical" containerType="Other" firstNeighbor="GllsaRsHZUOo1T5JiPknaA" secondNeighbor="agEz-d8UnU2AlENh6qiY5A">
-              <Tags>
-                <Tag value="Neighborhood: UpperIleum / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="VttZd-88d0WsHkmMnG5AAA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="ZFudx6zC1k-KLECfoiEz2g" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="2LGZM-vQYka8xCZcybasBA" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_DrugAbsorption_para" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="bJyQ1nbGJ0ajnukl5-CvnQ" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  </Children>
-                </Container>
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="kMoa6jEp60mOEB-Vzc_AAg" name="SmallIntestine_bc_LowerJejunum_bc" description="Neighborhood between Small Intestine/Blood Cells_ and Lower Jejunum/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="n6xwS0M17UWg01nLAvRLIQ" secondNeighbor="JvhcU5G9sESOfI0HQ9iySg">
-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="n971X3VaTUagdWN4G0ZInA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="mvydYNIp60iifybuCS4bZQ" name="Mass transfer rate (intestine to mucosa blood cells)" description="Mass transfer rate (intestine to mucosa blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaBloodCells" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  </Children>
-                </Container>
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="8GzCNQURiU2fCK8DKjjGkg" name="SmallIntestine_pls_LowerJejunum_pls" description="Neighborhood between Small Intestine/Plasma_ and Lower Jejunum/Plasma" mode="Logical" containerType="Other" firstNeighbor="bKNuXngQSk-SQQe7D3MkAw" secondNeighbor="1XxBZvONAEWWEWN1gOg4VQ">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="V9DuXZm2QEy2mQcInsZQaA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="0FYLPTuAa0KTezmKDq06Tw" name="Mass transfer rate (intestine to mucosa plasma)" description="Mass transfer rate (intestine to mucosa plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaPlasma" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  </Children>
-                </Container>
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="6p0xIl1QukW4FrHJsZBciA" name="SmallIntestine_bc_UpperIleum_bc" description="Neighborhood between Small Intestine/Blood Cells_ and Upper Ileum/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="n6xwS0M17UWg01nLAvRLIQ" secondNeighbor="o2sI8fS0SkSgY4brbhcmyA">
-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="-OyEQ3WXx02-VUM7-sE7ew" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="sFy4bcMk4UK969uJLZUx4g" name="Mass transfer rate (intestine to mucosa blood cells)" description="Mass transfer rate (intestine to mucosa blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaBloodCells" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  </Children>
-                </Container>
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="SeDiYNMTjkiHEhobE46iNw" name="SmallIntestine_bc_UpperJejunum_bc" description="Neighborhood between Small Intestine/Blood Cells_ and Upper Jejunum/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="n6xwS0M17UWg01nLAvRLIQ" secondNeighbor="Ej30rRxCREi_lFbIacWhBg">
-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="P6mN7RugdEyiYUiSikPkyA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="b8wYZNQf9kWrtRX0FnD2xQ" name="Mass transfer rate (intestine to mucosa blood cells)" description="Mass transfer rate (intestine to mucosa blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaBloodCells" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  </Children>
-                </Container>
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="Kq2wIa9rdkSK7rMqzWXz7g" name="SmallIntestine_pls_UpperJejunum_pls" description="Neighborhood between Small Intestine/Plasma_ and Upper Jejunum/Plasma" mode="Logical" containerType="Other" firstNeighbor="bKNuXngQSk-SQQe7D3MkAw" secondNeighbor="BfP4xKdBX0SaUMpMCDXvbg">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="0bZz-gkFUkSUY2MWTEUSLA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="vz8UvpJMpEyUA-5RxaHZpg" name="Mass transfer rate (intestine to mucosa plasma)" description="Mass transfer rate (intestine to mucosa plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaPlasma" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  </Children>
-                </Container>
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="hiXefjVVwki9hAGOE1UYiA" name="SmallIntestine_bc_Duodenum_bc" description="Neighborhood between Small Intestine/Blood Cells_ and Duodenum/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="n6xwS0M17UWg01nLAvRLIQ" secondNeighbor="u4Ub16oEtECALrodgFre4w">
-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="kI0Ucc84QEicmFMK-2bmmg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="VMgP0S-WRUSkp8K9QigfAw" name="Mass transfer rate (intestine to mucosa blood cells)" description="Mass transfer rate (intestine to mucosa blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaBloodCells" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  </Children>
-                </Container>
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="YzHP6Rj6XUWW5HzGbr21PQ" name="SmallIntestine_pls_Duodenum_pls" description="Neighborhood between Small Intestine/Plasma_ and Duodenum/Plasma" mode="Logical" containerType="Other" firstNeighbor="bKNuXngQSk-SQQe7D3MkAw" secondNeighbor="EkzIKZP1wU2_9u7Ncqke-Q">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="4vB73xiW6U-cpIQQCDdDTA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="HQO4FDHR9U2rY6WfD_67NQ" name="Mass transfer rate (intestine to mucosa plasma)" description="Mass transfer rate (intestine to mucosa plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaPlasma" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  </Children>
-                </Container>
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="FFpVnZ4wIEOzerBdi93O7g" name="SmallIntestine_pls_UpperIleum_pls" description="Neighborhood between Small Intestine/Plasma_ and Upper Ileum/Plasma" mode="Logical" containerType="Other" firstNeighbor="bKNuXngQSk-SQQe7D3MkAw" secondNeighbor="agEz-d8UnU2AlENh6qiY5A">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="Z5sc0uEpsUai5fSbEeSdCg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="y7OGJ4KxMUSL2EfrtEVpIQ" name="Mass transfer rate (intestine to mucosa plasma)" description="Mass transfer rate (intestine to mucosa plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaPlasma" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  </Children>
-                </Container>
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="O4XKroje0EGz5z2W4q-gDQ" name="LowerIleum_bc_PortalVein_bc" description="Neighborhood between Lower Ileum/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="ziNIenMYrkK_Eu94Cg5BFQ" secondNeighbor="ghMacG-81kSUPN5wkgPsnA">
-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="xIVL0VAb4UKoDoWw4zKYBg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="FDE6gZEq4k-j5jsVz5JbLw" name="Mass transfer rate (mucosa to portal vein blood cells)" description="Mass transfer rate (mucosa to portal vein blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPveBloodCells" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  </Children>
-                </Container>
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="lg-cvn-NQUOomEaN9kAjKg" name="LowerIleum_pls_PortalVein_pls" description="Neighborhood between Lower Ileum/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="SheBaQRntUS7Uq436niclQ" secondNeighbor="-btXNr8mOEG_8ZCjsspLow">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="Tz6cGbFQDEuV3L0ftX7OwQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="uOGiA8L5n0mobYSTTG5ZlQ" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPvePlasma" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  </Children>
-                </Container>
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="QS2Jm7ILeEicdYs6aj2dEw" name="SmallIntestine_bc_LowerIleum_bc" description="Neighborhood between Small Intestine/Blood Cells_ and Lower Ileum/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="n6xwS0M17UWg01nLAvRLIQ" secondNeighbor="ziNIenMYrkK_Eu94Cg5BFQ">
-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="7ybB9cBdbUWvPGyCDEZaUw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="xzRjUOICckCbcz4BbXhmMw" name="Mass transfer rate (intestine to mucosa blood cells)" description="Mass transfer rate (intestine to mucosa blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaBloodCells" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  </Children>
-                </Container>
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="-MKpccwtv0ilmxXUAiaYMw" name="SmallIntestine_pls_LowerIleum_pls" description="Neighborhood between Small Intestine/Plasma_ and Lower Ileum/Plasma" mode="Logical" containerType="Other" firstNeighbor="bKNuXngQSk-SQQe7D3MkAw" secondNeighbor="SheBaQRntUS7Uq436niclQ">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="nb9NnwOF2UOUkV-6PXTmnw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="M_O3uGOE-km2nxIcekyrZQ" name="Mass transfer rate (intestine to mucosa plasma)" description="Mass transfer rate (intestine to mucosa plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaPlasma" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  </Children>
-                </Container>
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="QWTnF4AbD0GR4YItyXNfTQ" name="Lumen_lil_LowerIleum_cell" description="Neighborhood between Lumen/Lower Ileum and Mucosa/Lower Ileum/Intracellular" mode="Logical" containerType="Other" firstNeighbor="vCPS2yMfPkKIhDcs0uJgFQ" secondNeighbor="an9mtKGGd0m69RC9jFTrLA">
-              <Tags>
-                <Tag value="Neighborhood: LowerIleum / Intracellular" />
-              </Tags>
-              <Children>
-                <Container id="FPaCsvTJBkuT8rXMGU3EOw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="Bucojw16iECS-HwP9HvoFg" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F2" visible="0" canBeVaried="0" />
-                    <Parameter id="eHiz-XHVlUK9XiPaUQwnHw" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F3" visible="0" canBeVaried="0" />
-                    <Parameter id="L5W0ZMzeo0GI0O51aWNK6w" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K1" visible="0" canBeVaried="0" />
-                    <Parameter id="u8dkg-pf5kakXjT09XFF7g" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K2" visible="0" canBeVaried="0" />
-                    <Parameter id="xybTZ6narU-T2KXC6r_xSQ" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K3" visible="0" canBeVaried="0" />
-                    <Parameter id="5Dm_pA5iPk65wEGCS2O-2w" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K4" visible="0" canBeVaried="0" />
-                    <Parameter id="s2co4Q-1SkCBdr3ifYtDTQ" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K5" visible="0" canBeVaried="0" />
-                    <Parameter id="DVXQk_NzhkKcuxU2XJq02w" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K6" visible="0" canBeVaried="0" />
-                    <Parameter id="3uxjSDP2xU2--9RxSplejA" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K7" visible="0" canBeVaried="0" />
-                    <Parameter id="uHcXrfR39kGthu-m-6FiTA" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K8" visible="0" canBeVaried="0" />
-                    <Parameter id="n1UBo4HVvkiasz227fM8GQ" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="K9zziCu-F0m43y5gGVoKnA" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K7" visible="0" canBeVaried="0" />
-                    <Parameter id="W78srkq2nUSagrODSLzjqA" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="s1nJcxALSEKE82gEU-Kcog" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_lum_cell_factor" visible="0" canBeVaried="0" />
-                    <Parameter id="65JdDwMY0kqxiyChH3DBcw" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F1" visible="0" canBeVaried="0" />
-                    <Parameter id="EJtFijp6x0GpGiCslbT93A" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_cell_lum_factor" visible="0" canBeVaried="0" />
-                    <Parameter id="Jsikb_K4ukOTQr2NypKovQ" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K8" visible="0" canBeVaried="0" />
-                    <Parameter id="loKnrk_m8Uaja8gnLj9z5A" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Lumen_PKSim.PARAM_K_cell_pls_LowerIleum" visible="0" canBeVaried="0" />
-                    <Parameter id="nqc8vM_ERkObocfG9aXdYw" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_LowerIleum" visible="0" canBeVaried="1" />
-                    <Parameter id="CSnCIS1yrkejcKV9lDhAYw" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F1" visible="0" canBeVaried="0" />
-                    <Parameter id="qlUJWnXjkUmMccKLVUShWw" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F2" visible="0" canBeVaried="0" />
-                    <Parameter id="K-RCFwjllUWfc_bIuO2LdA" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F3" visible="0" canBeVaried="0" />
-                    <Parameter id="2jXXT2n_2EG6fcbz6xHOxw" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K1" visible="0" canBeVaried="0" />
-                    <Parameter id="U9db6gbW-Uqqc7tr3zsDNA" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K2" visible="0" canBeVaried="0" />
-                    <Parameter id="hrsUTCYxUEK8xYQhJc1xjQ" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K3" visible="0" canBeVaried="0" />
-                    <Parameter id="9ENJAQOdbk6p23AxIfv8Sw" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K4" visible="0" canBeVaried="0" />
-                    <Parameter id="B03K2fZP0kq6XitcDLTVQg" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K5" visible="0" canBeVaried="0" />
-                    <Parameter id="MAfjMOJArkSuu3IkN3uPLw" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K6" visible="0" canBeVaried="0" />
-                    <Parameter id="_Vf5EPPFRUSt9KlZJQGXug" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_DrugAbsorption_trans" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  </Children>
-                </Container>
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="72bNBLX320emOf57IkxEQw" name="Lumen_lil_LowerIleum_pls" description="Neighborhood between Lumen/Lower Ileum and Mucosa/Lower Ileum/Plasma" mode="Logical" containerType="Other" firstNeighbor="vCPS2yMfPkKIhDcs0uJgFQ" secondNeighbor="SheBaQRntUS7Uq436niclQ">
-              <Tags>
-                <Tag value="Neighborhood: LowerIleum / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="iRiO1YL86ke4QlBQAom0nA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="Lj1jaY6-DEqJ4GW88moTAg" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_DrugAbsorption_para" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="DluZXZ--9kmn5iF2_gNY_w" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="0ZIn3S1Z80OiHSdKUcxsbQ" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  </Children>
-                </Container>
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="jgWzaqflz0qtLEKSlUDr9Q" name="SmallIntestine_int_SmallIntestine_cell" description="Neighborhood between Small Intestine/Interstitial and Small Intestine/Intracellular" mode="Logical" containerType="Other" firstNeighbor="QQEEFQ5iKUyN-6sUySP6Ig" secondNeighbor="eTOwNAWOSU2qVPwOLXoz1w">
-              <Tags>
-                <Tag value="Neighborhood: Interstitial / Intracellular" />
-                <Tag value="Small intestine  neighborhood" />
-              </Tags>
-              <Children>
-                <Container id="YqUZq6MAyUGoIn7XeFHrwg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="FSmQJGo6gE-qNX5KeddADQ" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                    <Parameter id="pqwKa4imtkqqHB7FN93PQQ" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                    <Parameter id="0f_XKZnmzEGWHIRPo80AqQ" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="HsknSPCi7UuxGJhWoB4CXA" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="guz8C3SKt0STDT86Aeu7QQ" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" visible="0" canBeVaried="1" />
-                    <Parameter id="sfXkwO2-e02nrYyjwUxCwA" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" visible="0" canBeVaried="1" />
-                    <Parameter id="KH9lb-8HrUqE9b460t48MA" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" visible="1" canBeVaried="1" />
-                    <Parameter id="WoE2nVWjM0CIEuB6DlK32w" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" visible="0" canBeVaried="1" />
-                  </Children>
-                </Container>
-                <Parameter id="7OIGcBoUeEKGEEqYZSNW4A" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_sin" visible="1" canBeVaried="1" displayUnit="cm²" />
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="CfU6WeJW-UCOtkedaaWGmw" name="SmallIntestine_pls_SmallIntestine_int" description="Neighborhood between Small Intestine/Plasma and Small Intestine/Interstitial" mode="Logical" containerType="Other" firstNeighbor="bKNuXngQSk-SQQe7D3MkAw" secondNeighbor="QQEEFQ5iKUyN-6sUySP6Ig">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Interstitial" />
-                <Tag value="Small intestine  neighborhood" />
-              </Tags>
-              <Children>
-                <Container id="Uxs1PVMVmEmC6FgOHncp4w" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="wnZyVTsp8EOaA2zX_OiqZg" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" visible="1" canBeVaried="1" />
-                    <Parameter id="imErF4NgxUu7TSLhf-yO0Q" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" visible="1" canBeVaried="1" value="10" displayUnit="cm/min" />
-                  </Children>
-                </Container>
-                <Parameter id="I4uVVcCUp0ywlwslaavZOg" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int_sinlin" visible="1" canBeVaried="1" displayUnit="cm²" />
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="2De66y5MfkmZ1dzFPNyFoA" name="SmallIntestine_pls_SmallIntestine_bc" description="Neighborhood between Small Intestine/Plasma and Small Intestine/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="bKNuXngQSk-SQQe7D3MkAw" secondNeighbor="n6xwS0M17UWg01nLAvRLIQ">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / BloodCells" />
-                <Tag value="Small intestine  neighborhood" />
-              </Tags>
-              <Children>
-                <Container id="viBINDHBWU-jSW-j8uqjnA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-                <Parameter id="jSPK9ilsgkKZHpM4mLUwqg" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls_sinlin" visible="1" canBeVaried="1" displayUnit="cm²" />
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="sQJDWHoXAUSL9jbFLyswhA" name="SmallIntestine_pls_PortalVein_pls" description="Neighborhood between Small Intestine/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="bKNuXngQSk-SQQe7D3MkAw" secondNeighbor="-btXNr8mOEG_8ZCjsspLow">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="zyJ9m3hBHU-vGlQFiTfB8g" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="ThIe-01caUeexuSHpSDPvQ" name="SmallIntestine_bc_PortalVein_bc" description="Neighborhood between Small Intestine/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="n6xwS0M17UWg01nLAvRLIQ" secondNeighbor="ghMacG-81kSUPN5wkgPsnA">
-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="1siPrNONk0m287lKHxNQkg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="yObW1CONb0CBP837ALFL_Q" name="LargeIntestine_bc_PortalVein_bc" description="Neighborhood between Large Intestine/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="PHp1m9J9BUW9Wt4S_ZSJwQ" secondNeighbor="ghMacG-81kSUPN5wkgPsnA">
-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="s-4SKES7AEux0NBdk5tysQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="zKNgga0vLEKOLHttadHekQ" name="LargeIntestine_bc_Rectum_bc" description="Neighborhood between Large Intestine/Blood Cells_ and Rectum/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="PHp1m9J9BUW9Wt4S_ZSJwQ" secondNeighbor="A3QoloDj00WaEjb1ONwwKw">
-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="yWoQ_jNagECd3ezYdpsb4A" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="pdyWuNrUG0GRMOTnJbs_Iw" name="Mass transfer rate (intestine to mucosa blood cells)" description="Mass transfer rate (intestine to mucosa blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaBloodCells" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  </Children>
-                </Container>
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="x8b0o-sH0k2bTldDJBH6Aw" name="LargeIntestine_pls_Rectum_pls" description="Neighborhood between Large Intestine/Plasma_ and Rectum/Plasma" mode="Logical" containerType="Other" firstNeighbor="pX3ccCxXKEyKOoR4QI5kRg" secondNeighbor="CXXEeRMxZU-wWTrT4YIzVA">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="qbGPo_pAZkybx6gMt-s7Pg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="iRFmyN7tGkarZD4jq36dNA" name="Mass transfer rate (intestine to mucosa plasma)" description="Mass transfer rate (intestine to mucosa plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaPlasma" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  </Children>
-                </Container>
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="OXjxFxxVG0qCQEC2jrKvwg" name="LargeIntestine_bc_ColonSigmoid_bc" description="Neighborhood between Large Intestine/Blood Cells_ and Colon Sigmoid/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="PHp1m9J9BUW9Wt4S_ZSJwQ" secondNeighbor="LQuH1MHvJ0af2kvb_nXBJQ">
-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="_2uvc9eE9katB1GeJJr3Kw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="qq4xDt-n3kmDEo67M5W-_Q" name="Mass transfer rate (intestine to mucosa blood cells)" description="Mass transfer rate (intestine to mucosa blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaBloodCells" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  </Children>
-                </Container>
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="ATim0hXz3k6PbKFCMmi3-w" name="LargeIntestine_pls_ColonSigmoid_pls" description="Neighborhood between Large Intestine/Plasma_ and Colon Sigmoid/Plasma" mode="Logical" containerType="Other" firstNeighbor="pX3ccCxXKEyKOoR4QI5kRg" secondNeighbor="pJmj_UrpO0ioIgKx0SwyWg">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="64fFrTc8zUiZHZgM3JHmSA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="R8l5iyDLcU61ZRGPU1AhAA" name="Mass transfer rate (intestine to mucosa plasma)" description="Mass transfer rate (intestine to mucosa plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaPlasma" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  </Children>
-                </Container>
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="brZGRABubE-LZIeP8TEF2Q" name="LargeIntestine_bc_ColonDescendens_bc" description="Neighborhood between Large Intestine/Blood Cells_ and Colon Descendens/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="PHp1m9J9BUW9Wt4S_ZSJwQ" secondNeighbor="wT5qkJMuWE6Wx6caeYjFJQ">
-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="BfjGKXoMlkiXZPaw0rG3QQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="J1jdmFi44E6dSbNodsDplw" name="Mass transfer rate (intestine to mucosa blood cells)" description="Mass transfer rate (intestine to mucosa blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaBloodCells" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  </Children>
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-            <NeighborhoodBuilder id="Pt-cIDAnfkypv8Z8krA91w" name="LargeIntestine_pls_ColonDescendens_pls" description="Neighborhood between Large Intestine/Plasma_ and Colon Descendens/Plasma" mode="Logical" containerType="Other" firstNeighbor="pX3ccCxXKEyKOoR4QI5kRg" secondNeighbor="xjPErKtgLE2tSY7-piU_pw">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="i2dleMZfwUmqD5OVIVhdeg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="biDkhm4DU02FWyYIClf-HQ" name="Mass transfer rate (intestine to mucosa plasma)" description="Mass transfer rate (intestine to mucosa plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaPlasma" visible="0" canBeVaried="0" displayUnit="µmol/min" />
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-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="ZQG4Ss0qJkGFTt85-2eE1g" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="AwCPHOsIlkyFQVpJ7aeMKw" name="Mass transfer rate (intestine to mucosa blood cells)" description="Mass transfer rate (intestine to mucosa blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaBloodCells" visible="0" canBeVaried="0" displayUnit="µmol/min" />
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-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="pzZ3W1SglUSRg8jPyJAO-A" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="DK2WV4s_sUmzie9d5aL50A" name="Mass transfer rate (intestine to mucosa blood cells)" description="Mass transfer rate (intestine to mucosa blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaBloodCells" visible="0" canBeVaried="0" displayUnit="µmol/min" />
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-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
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-              <Children>
-                <Container id="CvK6bujqjkmqc4hGFt5VmA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="8JYRlu2NO0y3yFEpFrNmDA" name="Mass transfer rate (intestine to mucosa plasma)" description="Mass transfer rate (intestine to mucosa plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaPlasma" visible="0" canBeVaried="0" displayUnit="µmol/min" />
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-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
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-              <Children>
-                <Container id="DQqtTNS2bkS6KzBE-D_yYw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="DGVBNfZM5kmVhNUZWnRvww" name="Mass transfer rate (intestine to mucosa blood cells)" description="Mass transfer rate (intestine to mucosa blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaBloodCells" visible="0" canBeVaried="0" displayUnit="µmol/min" />
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-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
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-              <Children>
-                <Container id="DvBKceVJJkKEoySfSXY2Rg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="U8heV4daOkuIcnU_S3bHxQ" name="Mass transfer rate (intestine to mucosa plasma)" description="Mass transfer rate (intestine to mucosa plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaPlasma" visible="0" canBeVaried="0" displayUnit="µmol/min" />
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-              <Tags>
-                <Tag value="Large intestine  neighborhood" />
-                <Tag value="Neighborhood: Plasma / BloodCells" />
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-              <Children>
-                <Container id="VL-Htk6hikyQxIb9P1Ejwg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-                <Parameter id="vCc3RLhJ0E29GYS9QhLa1w" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls_sinlin" visible="1" canBeVaried="1" displayUnit="cm²" />
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-              <Tags>
-                <Tag value="Large intestine  neighborhood" />
-                <Tag value="Neighborhood: Interstitial / Intracellular" />
-              </Tags>
-              <Children>
-                <Container id="FwCNptpuY0i1VHxdcQ72jQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="jO1kTcakzE-hooBCgQS7eA" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                    <Parameter id="FNHBNnlEP0GN1_LUfFqP1A" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                    <Parameter id="sHjKS_rB0ECqJy-hbrcUmw" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="3UUT_hyZ7Eim9rB3aK1U6Q" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="lcK_tIxdu0KdGrWzwe5RbA" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" visible="0" canBeVaried="1" />
-                    <Parameter id="yKqTX3JTZU2SrG23zZXStA" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" visible="0" canBeVaried="1" />
-                    <Parameter id="zfaHqNdfY0uKSCmAUSiiTw" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" visible="1" canBeVaried="1" />
-                    <Parameter id="-JH3_iMWeEeEpj0TgFIbFg" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" visible="0" canBeVaried="1" />
-                  </Children>
-                </Container>
-                <Parameter id="A6brwgQtfki_W_xWrW13uQ" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_lin" visible="1" canBeVaried="1" displayUnit="cm²" />
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-            <NeighborhoodBuilder id="D9TNvmLUTEic2EIDks3hDQ" name="LargeIntestine_pls_LargeIntestine_int" description="Neighborhood between Large Intestine/Plasma and Large Intestine/Interstitial" mode="Logical" containerType="Other" firstNeighbor="pX3ccCxXKEyKOoR4QI5kRg" secondNeighbor="0OwBcRx450qQxH3cgG_UQg">
-              <Tags>
-                <Tag value="Large intestine  neighborhood" />
-                <Tag value="Neighborhood: Plasma / Interstitial" />
-              </Tags>
-              <Children>
-                <Container id="-0lyOGXHlki1S9AKFZefoQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="svzRSjRcKEi8H1Kr2MZ3hg" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" visible="1" canBeVaried="1" value="10" displayUnit="cm/min" />
-                    <Parameter id="ruuDiia79kGLIZCXPvUqow" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" visible="1" canBeVaried="1" />
-                  </Children>
-                </Container>
-                <Parameter id="2bLzN_54dkGTxfQDik3ePw" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int_sinlin" visible="1" canBeVaried="1" displayUnit="cm²" />
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-            <NeighborhoodBuilder id="gqO_OXHr_0GjMB6JNCjFXg" name="LargeIntestine_pls_Caecum_pls" description="Neighborhood between Large Intestine/Plasma_ and Cecum/Plasma" mode="Logical" containerType="Other" firstNeighbor="pX3ccCxXKEyKOoR4QI5kRg" secondNeighbor="LGbzLR1sNEiVJUOKeIrgIw">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="GC1uRazve0WcCO0958jrQg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="vUYBSFKzjUKfFIr3s0vsDw" name="Mass transfer rate (intestine to mucosa plasma)" description="Mass transfer rate (intestine to mucosa plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaPlasma" visible="0" canBeVaried="0" displayUnit="µmol/min" />
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-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="3R4cgESkmkGu2F94WA7s_A" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
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-              <Tags>
-                <Tag value="Neighborhood: Plasma / BloodCells" />
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-              <Children>
-                <Container id="Zodh0ospGkyhAk_N_glr2Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-                <Parameter id="89K3GDhUMUysuVWtX2G3CA" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" visible="1" canBeVaried="1" displayUnit="cm²" />
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-            <NeighborhoodBuilder id="jIIZ4UEP50uFBYAp2JPR-Q" name="Liver_pls_VenousBlood_pls" description="Neighborhood between Liver/Plasma and Venous Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="kLQaFdxWjEyQKZou_zICsg" secondNeighbor="AsKjCr0qtU6a-XJrIrGPTA">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="uNVeNOpFXU-D7GBamKVRkw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              </Children>
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-              <Tags>
-                <Tag value="Neighborhood: Interstitial / Intracellular" />
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-              <Children>
-                <Container id="h8gIyQc9jE-fIpZuFGpmkA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="W_5VDBnJ3UerLhWlnc_Y4Q" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="-itw44nXtk2KfEkYy7lVdQ" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" visible="0" canBeVaried="1" />
-                    <Parameter id="kxv0frjVzUiSHLDKEsN5HA" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" visible="1" canBeVaried="1" />
-                    <Parameter id="3Q860lbw4UCVC_9ebWyR-w" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" visible="0" canBeVaried="1" />
-                    <Parameter id="RxtWaJ33eUG62FJpPOPMiQ" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="s4pPXGOWh0Oec7RmA5SrkA" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" visible="0" canBeVaried="1" />
-                    <Parameter id="clOL1sNcek6nT1W5HUxxyA" name="Min (PA, Q)" description="Minimum between permeability and blood flow" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="PlasmaClearance_PKSim.PARAM_min_PA_Q" visible="0" canBeVaried="0" displayUnit="l/min" />
-                    <Parameter id="aCItvs3NVEqr_i0Q7v7B5A" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                    <Parameter id="mWSkjNXyFUiLwi-3ap5INA" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" visible="1" canBeVaried="1" displayUnit="cm/min" />
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-                </Container>
-                <Parameter id="-dEZOPRTiUiakw1OOfS8eg" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_liv" visible="1" canBeVaried="1" displayUnit="cm²" />
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-              <Tags>
-                <Tag value="Neighborhood: Plasma / Interstitial" />
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-              <Children>
-                <Container id="VY3JlGvBvEa8lnyjdgZegw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="mthxw-EUOEGx9_JH-YuVlQ" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" visible="1" canBeVaried="1" value="10" displayUnit="cm/min" />
-                    <Parameter id="dYRvncJEtE6v4aW5uasgQg" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" visible="1" canBeVaried="1" />
-                  </Children>
-                </Container>
-                <Parameter id="QaU_ktJR5k21FYDGQ_1U3g" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" visible="1" canBeVaried="1" displayUnit="cm²" />
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-              <Tags>
-                <Tag value="Neighborhood: Gallbladder / Duodenum" />
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-              <Children>
-                <Container id="feAGzaXR_ku91JCg_0_cRg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
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-            <NeighborhoodBuilder id="LJ_bCpOfu0-lk5p7bHvBRQ" name="Liver_cell_Lumen_duo" description="Neighborhood between Liver/Intracellular and Lumen/Duodenum" mode="Logical" containerType="Other" firstNeighbor="WiPCGGPb6EybGjmu7KSb3g" secondNeighbor="B2SJL0T_506x1Wlk3TTamQ">
-              <Tags>
-                <Tag value="Neighborhood: Intracellular / Duodenum" />
-              </Tags>
-              <Children>
-                <Container id="Ite73FM7Gk67q4L6RvX9mw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="hNv5KtOzcUuhul7yAQg6Xw" name="Liver_cell_Gallbladder" description="Neighborhood between Liver/Intracellular and Gallbladder" mode="Logical" containerType="Other" firstNeighbor="WiPCGGPb6EybGjmu7KSb3g" secondNeighbor="EOCNYCiyR0-ddQmB3lY2mg">
-              <Tags>
-                <Tag value="Neighborhood: Intracellular / Gallbladder" />
-              </Tags>
-              <Children>
-                <Container id="WKD1gdFlUUu81SNQ2NY4Ng" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="lWqFWx6R7EOtNV4AuTjd1g" name="Liver_bc_VenousBlood_bc" description="Neighborhood between Liver/Blood Cells and Venous Blood/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="yvxjl1guzkC2ZmC3cHheTA" secondNeighbor="tLK5A0Qv_EaJTZDJ7FqJQA">
-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="zYGlT-GJ4EC_XO7RlnlyEQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
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-              <Tags>
-                <Tag value="Neighborhood: Plasma / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="O88PWU9XPUGNWNLy91jOYw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-                <Parameter id="UIm_ij36cEaBci064oPs-A" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" visible="1" canBeVaried="1" displayUnit="cm²" />
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-              <Tags>
-                <Tag value="Neighborhood: Plasma / Interstitial" />
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-              <Children>
-                <Container id="ODx17UBNaECPCUvnbw4VCA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="SH34eJNXvUGzaoBNq3AcKw" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" visible="1" canBeVaried="1" />
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-                <Parameter id="fx1v1fm4ZE-vCf-ozbPucQ" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" visible="1" canBeVaried="1" displayUnit="cm²" />
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-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
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-              <Children>
-                <Container id="4zeq1Zi3ZU6fX5FZ33_Jqw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
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-            <NeighborhoodBuilder id="wbKa3P7Sd0mXdvW3-K81zg" name="Lung_bc_ArterialBlood_bc" description="Neighborhood between Lung/Blood Cells and Arterial Blood/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="sntQYIleCUO8SGMqvmOx9A" secondNeighbor="BuQVS6yXyUaIq4-4XAWfSA">
-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
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-              <Children>
-                <Container id="dw9y1jP5tUm1a8JA8oTFug" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
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-              <Tags>
-                <Tag value="Neighborhood: Interstitial / Intracellular" />
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-              <Children>
-                <Container id="SX1qiBcVf0mvfIUHUFUyjA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
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-                    <Parameter id="_ljulGjIVkSIt4IKBZ5XQw" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                    <Parameter id="AGeHexT3rUOeBe7G_uxpYg" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                    <Parameter id="vZegWchGU0KLbh8-T9ALHg" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="lD6LEc7GZU2_WEVKbwD48Q" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="tcwFITEH206QcxiEJiHOkQ" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" visible="0" canBeVaried="1" />
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-                    <Parameter id="lse09wA9ikWK-PWY-msgYQ" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" visible="1" canBeVaried="1" />
-                    <Parameter id="nh5yFgD0kUq4nO3UBaFZ_A" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" visible="0" canBeVaried="1" />
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-                <Parameter id="MvyJy6taQUOyFQUWc6PRbw" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_lng" visible="1" canBeVaried="1" displayUnit="cm²" />
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-              <Tags>
-                <Tag value="Neighborhood: Interstitial / Intracellular" />
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-              <Children>
-                <Container id="UlShHMmY_U-xm4AxpXrgTA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="6q1w738rlUecd_cRpK8tSg" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" visible="0" canBeVaried="1" />
-                    <Parameter id="s046IicYF02w6f-9zvuGng" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                    <Parameter id="vF4Ry8j5OkCpzRjPH49qJA" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                    <Parameter id="ACC96ZnV2kSJuEQpBZvkdA" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="gqQ7puVk1kmQRo6NXKn0cQ" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" visible="0" canBeVaried="1" />
-                    <Parameter id="Ix25Q71WAk-Kg1ycS0XyUw" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" visible="1" canBeVaried="1" />
-                    <Parameter id="qH0SHClCj0evb0CLRc9Ngw" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" visible="0" canBeVaried="1" />
-                    <Parameter id="8CCclWAVTUmwm1qepYbTTQ" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" visible="0" canBeVaried="1" displayUnit="l/min" />
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-                <Parameter id="jpebWcM--ESxLB6X7NVyuQ" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mus" visible="1" canBeVaried="1" displayUnit="cm²" />
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-              <Tags>
-                <Tag value="Neighborhood: Plasma / BloodCells" />
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-              <Children>
-                <Container id="-Ag-ijjaJUGzgIEyddRFwA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-                <Parameter id="X0yEpv7UXESNImdp7y3abA" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" visible="1" canBeVaried="1" displayUnit="cm²" />
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-              <Tags>
-                <Tag value="Neighborhood: Plasma / Interstitial" />
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-              <Children>
-                <Container id="EusffzCdvkSklJyIbbx1_Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="rs8wq4gyBkmu2cYb18TkbQ" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" visible="1" canBeVaried="1" value="10" displayUnit="cm/min" />
-                    <Parameter id="xyhoah415kWUSE8ME31p_A" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" visible="1" canBeVaried="1" />
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-                <Parameter id="F-V09dRLMkSprp2FEALL_Q" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" visible="1" canBeVaried="1" displayUnit="cm²" />
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-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
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-              <Children>
-                <Container id="uNFqFGjJqE2Nx7m2ulINtQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
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-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
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-              <Children>
-                <Container id="W9ENwHooM0aplAjbhYgQDg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
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-              <Tags>
-                <Tag value="Neighborhood: Plasma / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="bI-yLRyz80KYzaIeDiUTJw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-                <Parameter id="Tr3Uwb2efk-t9c4fMBNFPw" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" visible="1" canBeVaried="1" displayUnit="cm²" />
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-              <Tags>
-                <Tag value="Neighborhood: Plasma / Interstitial" />
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-              <Children>
-                <Container id="4socIbPV_kiZDQyx2Ej3hg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="v0AJ9uR5NkSBM4AUdgLIlA" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" visible="1" canBeVaried="1" />
-                    <Parameter id="peuZs_yqmkulRvHImbQOfg" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" visible="1" canBeVaried="1" value="10" displayUnit="cm/min" />
-                  </Children>
-                </Container>
-                <Parameter id="y9EDW0BPsUq9YJ2ijXS37A" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" visible="1" canBeVaried="1" displayUnit="cm²" />
-              </Children>
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-            <NeighborhoodBuilder id="ypGg7YA1K0uJlSUqmWGFhw" name="Pancreas_pls_PortalVein_pls" description="Neighborhood between Pancreas/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="XpMoC77tqU2dbzFapP7yNA" secondNeighbor="-btXNr8mOEG_8ZCjsspLow">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
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-              <Children>
-                <Container id="yF6zo973Y0CswmoBOhOhjQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
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-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="X-NZf7QCmE-_sbaEUcTOJA" name="Pancreas_int_Pancreas_cell" description="Neighborhood between Pancreas/Interstitial and Pancreas/Intracellular" mode="Logical" containerType="Other" firstNeighbor="pqwFSmbk-EayJEjapSwGkg" secondNeighbor="tC2LTXmkVkuQv6mD-Lzfig">
-              <Tags>
-                <Tag value="Neighborhood: Interstitial / Intracellular" />
-              </Tags>
-              <Children>
-                <Container id="3faObynvWEy770K6kJwJfg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="7lwgzwhQJEaSSk8sxRnD_A" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                    <Parameter id="hK-t9nr4ckuXPWO-LvVHbA" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                    <Parameter id="hhNInswFTEyctTrnpWiH_g" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="QI2SvqSLC0S-X--n5Cw2Xg" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="l2CNSoKlAEqXnWqzsv4z5w" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" visible="0" canBeVaried="1" />
-                    <Parameter id="0v2mF9nWvEOyu6ANiykflQ" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" visible="0" canBeVaried="1" />
-                    <Parameter id="hLjzOjzOpUW-PRX0VYz0dw" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" visible="1" canBeVaried="1" />
-                    <Parameter id="t29_K7NrP0mAOPKtVR0H8g" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" visible="0" canBeVaried="1" />
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-                <Parameter id="3Tco4IMcEUyTwrX9KgxB5w" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_pan" visible="1" canBeVaried="1" displayUnit="cm²" />
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-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="Nsfi_iqkNEaCXqusNW-vbQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="06oJ_sL5HEafT8IBfGRmHQ" name="Lumen_rect_Rectum_cell" description="Neighborhood between Lumen/Rectum and Mucosa/Rectum/Intracellular" mode="Logical" containerType="Other" firstNeighbor="tl7DiBQWEUGwcvPUXLf68w" secondNeighbor="Wg0MyzCwzU6ebHpo_fikEg">
-              <Tags>
-                <Tag value="Neighborhood: Rectum / Intracellular" />
-              </Tags>
-              <Children>
-                <Container id="rkyrUuy47Eq7nqP30hh2gQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="jxoR--yBmU6K3YZ5FUSo9Q" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F1" visible="0" canBeVaried="0" />
-                    <Parameter id="7BHORjaAOUCCv7ZIwXzFIw" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_DrugAbsorption_trans" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="M_FoKxzPn0GDsS0BJn13kA" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_cell_lum_factor" visible="0" canBeVaried="0" />
-                    <Parameter id="t3sNvrMjgUyjaybIry-S0g" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_lum_cell_factor" visible="0" canBeVaried="0" />
-                    <Parameter id="Dtw4UyMOvE273d1OJSokOg" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Lumen_PKSim.PARAM_K_cell_pls_Rectum" visible="0" canBeVaried="0" />
-                    <Parameter id="O7qudR4apkKinIfcVcQabA" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F2" visible="0" canBeVaried="0" />
-                    <Parameter id="ubQEs4SiKEmx3TEP2yjYyg" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_Rectum" visible="0" canBeVaried="1" />
-                    <Parameter id="82w_gJQ5n0eA7Vlcc6RrKg" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K8" visible="0" canBeVaried="0" />
-                    <Parameter id="AIdunjvqn0ytRguzAFRrrw" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="7ks35SEt6EakJcCFTqCX8w" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="kgrXtl_Yv0OQSuoNq6Wrvg" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K5" visible="0" canBeVaried="0" />
-                    <Parameter id="IVtRWgrmiUu9EJk5P_kAVg" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F1" visible="0" canBeVaried="0" />
-                    <Parameter id="g3ShDJC5OEKZTFnt7rDuOQ" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F3" visible="0" canBeVaried="0" />
-                    <Parameter id="oJA0vCv-wUKA7pzbPsAmrA" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K1" visible="0" canBeVaried="0" />
-                    <Parameter id="NR_YbMd6akG_9jUpCih_-g" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K2" visible="0" canBeVaried="0" />
-                    <Parameter id="DASP8UxkU06qiHvdFgdjSw" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K3" visible="0" canBeVaried="0" />
-                    <Parameter id="gQnkWyohgUeHau0kIwMUjg" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K4" visible="0" canBeVaried="0" />
-                    <Parameter id="96UTn4sbv0q3siMsTDryOQ" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K5" visible="0" canBeVaried="0" />
-                    <Parameter id="S_0VOqmrYEG-GUeT921TCw" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K6" visible="0" canBeVaried="0" />
-                    <Parameter id="QQpr-ZjFSEiEjhpMmFf_kg" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K7" visible="0" canBeVaried="0" />
-                    <Parameter id="1af4Uh3nN0CTH7noBXZpVA" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K8" visible="0" canBeVaried="0" />
-                    <Parameter id="xE20xi1C8Uy20b2Jpse8xA" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K6" visible="0" canBeVaried="0" />
-                    <Parameter id="nFYGJ5b6WEq4ODuRhkDAxg" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F2" visible="0" canBeVaried="0" />
-                    <Parameter id="zJszE2J4zUi_r20_bE_RFA" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F3" visible="0" canBeVaried="0" />
-                    <Parameter id="gsYL-ZNEHkik6yNGZaPmew" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K1" visible="0" canBeVaried="0" />
-                    <Parameter id="thdo5aQf-Eq-JU9YN1cQhQ" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K2" visible="0" canBeVaried="0" />
-                    <Parameter id="36wPSBNnxkuq8G6VMlS3Ig" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K3" visible="0" canBeVaried="0" />
-                    <Parameter id="CY5Are94c062tZn7BDpfjg" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K4" visible="0" canBeVaried="0" />
-                    <Parameter id="H9nDxKm7tE2y1YFIKRpvbA" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K7" visible="0" canBeVaried="0" />
-                  </Children>
-                </Container>
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="TzK9t9mevk-t-6YYvpwGAA" name="Rectum_pls_PortalVein_pls" description="Neighborhood between Rectum/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="CXXEeRMxZU-wWTrT4YIzVA" secondNeighbor="-btXNr8mOEG_8ZCjsspLow">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="r4m1eE4uj024hsDg2J1Beg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="3vkGdmqE8EmwyNDHOQNrUQ" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPvePlasma" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  </Children>
-                </Container>
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="8fDxHU5RZE6GG6NDbIKFvw" name="Rectum_bc_PortalVein_bc" description="Neighborhood between Rectum/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="A3QoloDj00WaEjb1ONwwKw" secondNeighbor="ghMacG-81kSUPN5wkgPsnA">
-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="tRQGmYmHkU2fH9YtedJV0A" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="_vW73uYhTESvg_RKdwlDwg" name="Mass transfer rate (mucosa to portal vein blood cells)" description="Mass transfer rate (mucosa to portal vein blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPveBloodCells" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  </Children>
-                </Container>
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="Qra6SzKOKEOPxXgSBXY8Uw" name="Lumen_rect_Rectum_pls" description="Neighborhood between Lumen/Rectum and Mucosa/Rectum/Plasma" mode="Logical" containerType="Other" firstNeighbor="tl7DiBQWEUGwcvPUXLf68w" secondNeighbor="CXXEeRMxZU-wWTrT4YIzVA">
-              <Tags>
-                <Tag value="Neighborhood: Rectum / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="xgM0EDf8Qki34_3WFxsJ3w" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="dytF7-rYgk6_iQQa4D80Vw" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_DrugAbsorption_para" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="8Pvrkuaj9EKhPxogJVD0YQ" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="WL3TwsnOR0qgI1NYIY-XsQ" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  </Children>
-                </Container>
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="4iiwGaLqfESUvVzw9xeG8A" name="PortalVein_pls_Liver_pls" description="Neighborhood between PortalVein/Plasma and Liver/Plasma" mode="Logical" containerType="Other" firstNeighbor="-btXNr8mOEG_8ZCjsspLow" secondNeighbor="kLQaFdxWjEyQKZou_zICsg">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="6gTrjRu6LEaI19V-4-8cqw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="_mknA5vE4k2mRQPtiMhr4g" name="PortalVein_pls_PortalVein_bc" description="Neighborhood between PortalVein/Plasma and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="-btXNr8mOEG_8ZCjsspLow" secondNeighbor="ghMacG-81kSUPN5wkgPsnA">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="uM_SmutDrku8rz7oN0WLTQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-                <Parameter id="Etl_3ThYB0OH5VxuRom_aQ" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls_Blood_Organ" visible="1" canBeVaried="1" displayUnit="cm²" />
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="ynQ2F0aY8EecVhvTRFTrPQ" name="PortalVein_bc_Liver_bc" description="Neighborhood between PortalVein/Blood Cells and Liver/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="ghMacG-81kSUPN5wkgPsnA" secondNeighbor="yvxjl1guzkC2ZmC3cHheTA">
-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="mPqsAqRMbUuk54eXdfqi6w" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="GY_sFr1M506DZDukD1BPaw" name="Skin_pls_VenousBlood_pls" description="Neighborhood between Skin/Plasma and Venous Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="WSZy9a4tjEazdIfolnG7tQ" secondNeighbor="AsKjCr0qtU6a-XJrIrGPTA">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="x6tfWP2ZqUuUcRCJ0iOPGQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="ZsVOxIwoWk6D2cTjYZ7W9A" name="Skin_pls_Skin_bc" description="Neighborhood between Skin/Plasma and Skin/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="WSZy9a4tjEazdIfolnG7tQ" secondNeighbor="pPMIx8esx02hUpNFp0-EDQ">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="kIs-S-ZULky_P0e6-sdloQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-                <Parameter id="g43iMWCIxEmgz5k8byiUyw" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" visible="1" canBeVaried="1" displayUnit="cm²" />
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="nkNnQlyvDUCTvrz2Cwq32w" name="Skin_int_Skin_cell" description="Neighborhood between Skin/Interstitial and Skin/Intracellular" mode="Logical" containerType="Other" firstNeighbor="D2BE9ngGEUuvjzRqxqz8rQ" secondNeighbor="3we3dTuwDUm_9NjEJ_wiuA">
-              <Tags>
-                <Tag value="Neighborhood: Interstitial / Intracellular" />
-              </Tags>
-              <Children>
-                <Container id="1e5yq0y7zUKnPJcJwl4nsw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="V3I8pIwjPEK2Fg33fhG9Bg" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" visible="0" canBeVaried="1" />
-                    <Parameter id="oeJt16ebQE-wkygwX0gkMA" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" visible="1" canBeVaried="1" />
-                    <Parameter id="nBfv5uf0xUGFHnI7OJZHpg" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" visible="0" canBeVaried="1" />
-                    <Parameter id="hnRzxW2TmUuBmP0RilcXTA" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="YrUscu_V7kS2HT95K2z7WA" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" visible="0" canBeVaried="1" />
-                    <Parameter id="MeUxSjM__E6isRHaw2Rjhw" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="uhUxR3Eegkm9yBLHZ0ytmw" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                    <Parameter id="QYjibZ9U2Uu8ZeqmTN-JUQ" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                  </Children>
-                </Container>
-                <Parameter id="NP4orrfYRUCa3UuUXqjP0Q" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_skn" visible="1" canBeVaried="1" displayUnit="cm²" />
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="Tc3vPgdWY0Gp3ZxTtJk62g" name="Skin_pls_Skin_int" description="Neighborhood between Skin/Plasma and Skin/Interstitial" mode="Logical" containerType="Other" firstNeighbor="WSZy9a4tjEazdIfolnG7tQ" secondNeighbor="D2BE9ngGEUuvjzRqxqz8rQ">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Interstitial" />
-              </Tags>
-              <Children>
-                <Container id="XZESDiqw_Uif0PTMjieF5Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="bwtpVD8e2062DFtOPx-N9A" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" visible="1" canBeVaried="1" value="10" displayUnit="cm/min" />
-                    <Parameter id="1l_nbxQmPUaVKf0TUO_sbA" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" visible="1" canBeVaried="1" />
-                  </Children>
-                </Container>
-                <Parameter id="OlCO6vh1lUyy_Rk122rRhA" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" visible="1" canBeVaried="1" displayUnit="cm²" />
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="KwH0GGxA8Eer8rdc48WkDg" name="Skin_bc_VenousBlood_bc" description="Neighborhood between Skin/Blood Cells and Venous Blood/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="pPMIx8esx02hUpNFp0-EDQ" secondNeighbor="tLK5A0Qv_EaJTZDJ7FqJQA">
-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="dGlwGAvvLU6YTj6Jgl8VXQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="VrzB3987IUmAWzEZG3ghiQ" name="Spleen_pls_PortalVein_pls" description="Neighborhood between Spleen/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="K3klVlojjUGDpUNjF0hcjQ" secondNeighbor="-btXNr8mOEG_8ZCjsspLow">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="GYHibB5PpEmcwgRY3sizdg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              </Children>
-            </NeighborhoodBuilder>
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-              <Tags>
-                <Tag value="Neighborhood: Interstitial / Intracellular" />
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-              <Children>
-                <Container id="jeKovEYk9EuesnLFEVEqqA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
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-                    <Parameter id="_ElKZRkPMUuSRNgj93z93A" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                    <Parameter id="0fSi6Nfh50eodeuTA1QteQ" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="okWZGAWqtUO0PwlGiwAlRg" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" visible="0" canBeVaried="1" />
-                    <Parameter id="cgFRlcO5R0q6AFIB1MrswQ" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" visible="1" canBeVaried="1" />
-                    <Parameter id="Ik9vGupnt0CfK3fjxXRH3A" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" visible="0" canBeVaried="1" />
-                    <Parameter id="SMaiHHI-_UiAJZbtCvjBOQ" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" visible="0" canBeVaried="1" displayUnit="l/min" />
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-                <Parameter id="1EZA4I2RZkKHFP_QBUgzUA" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_spl" visible="1" canBeVaried="1" displayUnit="cm²" />
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-              <Tags>
-                <Tag value="Neighborhood: Plasma / Interstitial" />
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-                <Container id="7EnwSifCt0KMWsxjRRQgzA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="5rnNbsBzLE2_yi7hS6mTZw" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" visible="1" canBeVaried="1" value="10" displayUnit="cm/min" />
-                    <Parameter id="XJUK_XQBTEm_i2qoUyotoQ" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" visible="1" canBeVaried="1" />
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-                <Parameter id="JXIBi55paUSl_CQLwMaqHA" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" visible="1" canBeVaried="1" displayUnit="cm²" />
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-              <Tags>
-                <Tag value="Neighborhood: Plasma / BloodCells" />
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-              <Children>
-                <Container id="IZgQeNEb30GrwQxva9fCSg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-                <Parameter id="8MZRRiVDEk2RA-0q6gDTGw" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" visible="1" canBeVaried="1" displayUnit="cm²" />
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-                <Tag value="Neighborhood: BloodCells / BloodCells" />
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-              <Children>
-                <Container id="cB9X3BAXekGQNCTffoQSmg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
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-              <Tags>
-                <Tag value="Neighborhood: SalivaGland / Saliva" />
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-                <Container id="0uiSMzMk0EiMGrIuzsOcOQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="D2WMZWFLtkWt74Z-kQw4OA" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionSaliva_PKSim.PARAM_K_cell_pls_slv" visible="1" canBeVaried="1" />
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-              <Tags>
-                <Tag value="Neighborhood: Plasma / BloodCells" />
-                <Tag value="Small intestine  neighborhood" />
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-              <Children>
-                <Container id="6-a2sl5Zekyw_KQrpIk4KA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-                <Parameter id="wb0QXaDCjkCdp4WVFEEgAA" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" visible="1" canBeVaried="1" displayUnit="cm²" />
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-              <Tags>
-                <Tag value="Neighborhood: Plasma / Interstitial" />
-                <Tag value="Small intestine  neighborhood" />
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-              <Children>
-                <Container id="nydSKfchG0qEBXzojTKuUA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="d9DRKM3UTUS2U03XSHLZxw" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" visible="1" canBeVaried="1" value="10" displayUnit="cm/min" />
-                    <Parameter id="706VHqHqxkaVh0W3FFKseg" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" visible="1" canBeVaried="1" />
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-                <Parameter id="ruDLOprPTk6U0qruYImCiQ" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" visible="1" canBeVaried="1" displayUnit="cm²" />
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-              <Tags>
-                <Tag value="Neighborhood: Interstitial / Intracellular" />
-                <Tag value="Small intestine  neighborhood" />
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-              <Children>
-                <Container id="TERrKv5Nhkmrwr_R86rAEA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="EPhrZKiMA0WX0dR1vjYTXw" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_P_int_cell_Mucosa" visible="1" canBeVaried="1" displayUnit="cm/min" />
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-                    <Parameter id="MRdQH3djOE-0Rx2_3Mchpg" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_P_cell_int_Mucosa" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                    <Parameter id="br8HopUoWkSRZGuYK24UmQ" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="v9ojJ6-cf0yCBOjxR2WXtA" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" visible="0" canBeVaried="1" />
-                    <Parameter id="7MqKFEjy0E2-A_XI_LALUA" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" visible="1" canBeVaried="1" />
-                    <Parameter id="j3yGhp4Oh0yKYmTrkJ8BnA" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" visible="0" canBeVaried="1" />
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-                <Parameter id="0jaBI415qkSVAyr7FrEQxw" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mucosa_duo" visible="1" canBeVaried="1" displayUnit="cm²" />
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-              <Tags>
-                <Tag value="Neighborhood: Interstitial / Intracellular" />
-                <Tag value="Small intestine  neighborhood" />
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-              <Children>
-                <Container id="OLv07VaaoEGIXgl60K0pjg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="DnEwyt93EU27KFHBjRs37w" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" visible="0" canBeVaried="1" />
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-                    <Parameter id="5-zGGXFYYka-mQEzjJbg8g" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_P_cell_int_Mucosa" visible="1" canBeVaried="1" displayUnit="cm/min" />
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-                    <Parameter id="9wqCBKtGpkm9viAxMV3a8Q" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="ztGyFAhQC0KWYycSxvBJ5g" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" visible="0" canBeVaried="1" />
-                    <Parameter id="StbmHvRHvE2G7b-09HHLsw" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" visible="1" canBeVaried="1" />
-                    <Parameter id="lzmbNpfwFUGVDxa9F4Dx1w" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" visible="0" canBeVaried="1" />
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-                <Parameter id="1I96AODwVUC3igUGDd-Oeg" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mucosa_uje" visible="1" canBeVaried="1" displayUnit="cm²" />
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-              <Tags>
-                <Tag value="Neighborhood: Plasma / BloodCells" />
-                <Tag value="Small intestine  neighborhood" />
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-              <Children>
-                <Container id="RijqkFjhAUSKbXf2qpGHgA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-                <Parameter id="P6kzAY-UtkyyJFB5Y-aw2Q" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" visible="1" canBeVaried="1" displayUnit="cm²" />
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-              <Tags>
-                <Tag value="Neighborhood: Plasma / Interstitial" />
-                <Tag value="Small intestine  neighborhood" />
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-              <Children>
-                <Container id="3COLchtClEqD_POKPUd5rA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
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-                    <Parameter id="BKOQxOLqCU22D-3_dSmtkA" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" visible="1" canBeVaried="1" value="10" displayUnit="cm/min" />
-                    <Parameter id="tsXHAXV5yEeB4uVPH6E9MQ" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" visible="1" canBeVaried="1" />
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-                <Parameter id="eFYPkrM_ykG8bufGpdLE9w" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" visible="1" canBeVaried="1" displayUnit="cm²" />
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-              <Tags>
-                <Tag value="Neighborhood: Plasma / Interstitial" />
-                <Tag value="Small intestine  neighborhood" />
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-              <Children>
-                <Container id="W79-rH8OsUyIalC7u2EcFw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="vPB6D4kN-E2gsIXdk13d3w" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" visible="1" canBeVaried="1" value="10" displayUnit="cm/min" />
-                    <Parameter id="FJTEuo44TEypjvNH8KWmag" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" visible="1" canBeVaried="1" />
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-                <Parameter id="eUE-DZ1uRkyorkZpf4K0lA" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" visible="1" canBeVaried="1" displayUnit="cm²" />
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-              <Tags>
-                <Tag value="Neighborhood: Plasma / BloodCells" />
-                <Tag value="Small intestine  neighborhood" />
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-              <Children>
-                <Container id="ZEQmEzS6wECjK9QKHti16Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-                <Parameter id="tqkWv0OmgEO3HmAigraJLg" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" visible="1" canBeVaried="1" displayUnit="cm²" />
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-            <NeighborhoodBuilder id="9OBm5q5GjkSjov5ApyWbrQ" name="LowerJejunum_int_LowerJejunum_cell" description="Neighborhood between Small Intestine/Mucosa/Lower Jejunum/Interstitial and Small Intestine/Mucosa/Lower Jejunum/Intracellular" mode="Logical" containerType="Other" firstNeighbor="honL0CTkBUiLa6hPDJjRow" secondNeighbor="H45QSpDHZU6_rrF8B6S3IQ">
-              <Tags>
-                <Tag value="Neighborhood: Interstitial / Intracellular" />
-                <Tag value="Small intestine  neighborhood" />
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-                  </Children>
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-                <Parameter id="oJwrCpIhSU2-oDEkR-7_jQ" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mucosa_colsigm" visible="1" canBeVaried="1" displayUnit="cm²" />
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="PKbi-t53zEi9ZRTBNgzQ_Q" name="Rectum_pls_Rectum_int" description="Neighborhood between Large Intestine/Mucosa/Rectum/Plasma and Large Intestine/Mucosa/Rectum/Interstitial" mode="Logical" containerType="Other" firstNeighbor="CXXEeRMxZU-wWTrT4YIzVA" secondNeighbor="Ske4CMSGVEmut7Tm9FygjQ">
-              <Tags>
-                <Tag value="Large intestine  neighborhood" />
-                <Tag value="Neighborhood: Plasma / Interstitial" />
-              </Tags>
-              <Children>
-                <Container id="CDT-Ut1b3kmjC-OFUFynuA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="B8WHpoG4RkarMc1MHFaYtA" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" visible="1" canBeVaried="1" value="10" displayUnit="cm/min" />
-                    <Parameter id="OLeXvYT-vk-UbEG1Y12MSg" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" visible="1" canBeVaried="1" />
-                  </Children>
-                </Container>
-                <Parameter id="2R5TYizSwkiA4Xcvz26ulw" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" visible="1" canBeVaried="1" displayUnit="cm²" />
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="I9yPpkCBqUmc2ccJ5dzxcg" name="Rectum_pls_Rectum_bc" description="Neighborhood between Large Intestine/Mucosa/Rectum/Plasma and Large Intestine/Mucosa/Rectum/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="CXXEeRMxZU-wWTrT4YIzVA" secondNeighbor="A3QoloDj00WaEjb1ONwwKw">
-              <Tags>
-                <Tag value="Large intestine  neighborhood" />
-                <Tag value="Neighborhood: Plasma / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="Rr3JQck-C0u1y3eZOFWYug" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-                <Parameter id="YNumbnwSH0m7yZHJRLvJoA" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" visible="1" canBeVaried="1" displayUnit="cm²" />
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="uTPgjnMZx0yxA1BB9vUDog" name="Rectum_int_Rectum_cell" description="Neighborhood between Large Intestine/Mucosa/Rectum/Interstitial and Large Intestine/Mucosa/Rectum/Intracellular" mode="Logical" containerType="Other" firstNeighbor="Ske4CMSGVEmut7Tm9FygjQ" secondNeighbor="Wg0MyzCwzU6ebHpo_fikEg">
-              <Tags>
-                <Tag value="Large intestine  neighborhood" />
-                <Tag value="Neighborhood: Interstitial / Intracellular" />
-              </Tags>
-              <Children>
-                <Container id="BGOOVFHpD0GF75DzwLqkFA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="MrZSTyctKEanDu_LobVFIQ" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" visible="0" canBeVaried="1" />
-                    <Parameter id="HFqV--oR9E-F3jjKfl4isg" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_P_int_cell_Mucosa" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                    <Parameter id="arREll1JzUyw0e0Ylo5PFA" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_P_cell_int_Mucosa" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                    <Parameter id="XZevZgJjjUu85I0V_rkEIQ" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="jOLQUrpV602-fhAzE6FW2Q" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="qzaXVPJWdkeP8qjZ24UEBw" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" visible="0" canBeVaried="1" />
-                    <Parameter id="1QgbIMLxUUSDvlIjkZpcjg" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" visible="0" canBeVaried="1" />
-                    <Parameter id="Tx2t_xKZSUKcVWCtiZ7UMQ" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" visible="1" canBeVaried="1" />
-                  </Children>
-                </Container>
-                <Parameter id="Wu5LXTQDUUetJNxPMHuNlw" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mucosa_rect" visible="1" canBeVaried="1" displayUnit="cm²" />
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="rssMYGIlZkyYhkM0ae77LQ" name="Caecum_bc_PortalVein_bc" description="Neighborhood between Cecum/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="aBn4kASOREa7YsOFIEj5NA" secondNeighbor="ghMacG-81kSUPN5wkgPsnA">
-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="FefvuN8ZKEeGLjvzxLOTPg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="kW3o0NEAsUKgWNKG-aSLHA" name="Mass transfer rate (mucosa to portal vein blood cells)" description="Mass transfer rate (mucosa to portal vein blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPveBloodCells" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  </Children>
-                </Container>
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="vWw-JPAXj0et1dTQ4teJtA" name="Lumen_cae_Caecum_cell" description="Neighborhood between Lumen/Cecum and Mucosa/Cecum/Intracellular" mode="Logical" containerType="Other" firstNeighbor="sk41NH_8KEi_nNbtDlGvFA" secondNeighbor="Joj-umseKkiu2xQHcZDCWA">
-              <Tags>
-                <Tag value="Neighborhood: Caecum / Intracellular" />
-              </Tags>
-              <Children>
-                <Container id="Xg0uOBjrA06BPLehrM2_Bw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="cWb_jtSdqU-z-kiWVZs3gg" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_lum_cell_factor" visible="0" canBeVaried="0" />
-                    <Parameter id="DIpoG7vYsEGJDESOc7eNZw" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_DrugAbsorption_trans" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="LV3jW1Smuk64H70wmZODhw" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Lumen_PKSim.PARAM_K_cell_pls_Caecum" visible="0" canBeVaried="0" />
-                    <Parameter id="dYVT8V6TyUeQe1QIK9s1Jg" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_cell_lum_factor" visible="0" canBeVaried="0" />
-                    <Parameter id="8tgbD54Fw0SE5rgMrLT2tg" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F2" visible="0" canBeVaried="0" />
-                    <Parameter id="44bnmq2SFUul2WHXV95ryQ" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_Caecum" visible="0" canBeVaried="1" />
-                    <Parameter id="wKw0IY2YvUqKKqRqvyy7hQ" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F1" visible="0" canBeVaried="0" />
-                    <Parameter id="1Nd181hGiECvSzxoYlzvgg" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F2" visible="0" canBeVaried="0" />
-                    <Parameter id="u-A9SsD_CUegyYbyHJHfgg" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F3" visible="0" canBeVaried="0" />
-                    <Parameter id="8H-uiS831UmZu1njDfU2ng" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K1" visible="0" canBeVaried="0" />
-                    <Parameter id="6kvP0PD0qkSiilgUwvCK9g" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K2" visible="0" canBeVaried="0" />
-                    <Parameter id="4uedEQRCREehS9zYZEo1lw" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K3" visible="0" canBeVaried="0" />
-                    <Parameter id="Us6wtejmZUSFTBOucc518A" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K4" visible="0" canBeVaried="0" />
-                    <Parameter id="Pd2wsst5MEiaibelpFMmxg" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K5" visible="0" canBeVaried="0" />
-                    <Parameter id="6-dAUTy1A0W6yl-wqqc78g" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K6" visible="0" canBeVaried="0" />
-                    <Parameter id="O9963Q34u0m7nAZPsqT2pQ" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K7" visible="0" canBeVaried="0" />
-                    <Parameter id="wln6KZsKNEWr9JnbZwwTlQ" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F1" visible="0" canBeVaried="0" />
-                    <Parameter id="rkAnCPINEkGWcRtC7sEeYQ" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F3" visible="0" canBeVaried="0" />
-                    <Parameter id="TWW-flJo9k-BBtwGpJRyqQ" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K1" visible="0" canBeVaried="0" />
-                    <Parameter id="9dPtWAvlVU6VkMhlYx-pjA" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K2" visible="0" canBeVaried="0" />
-                    <Parameter id="gzXUhmBHIkqM2P6V_s0OFA" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K3" visible="0" canBeVaried="0" />
-                    <Parameter id="Jp4F676uxUCxIrHuHdFn8Q" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K4" visible="0" canBeVaried="0" />
-                    <Parameter id="SSMMQ63nDEGOj2tV6IeVbg" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K5" visible="0" canBeVaried="0" />
-                    <Parameter id="gZ3H7xz3fke4vdTIEc_ufQ" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K6" visible="0" canBeVaried="0" />
-                    <Parameter id="JXz7FTXJ4E2KHd3wyFFKvw" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K7" visible="0" canBeVaried="0" />
-                    <Parameter id="4XTpH7VAOk6TtHx1KnuDYg" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K8" visible="0" canBeVaried="0" />
-                    <Parameter id="knHMOTGcAEesGP-s_SXxNQ" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="WNSC0YGw40OmB4rZ8I2NpA" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="PpAHIquJO0WvIvqdeKfsiQ" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K8" visible="0" canBeVaried="0" />
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-                </Container>
-              </Children>
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-            <NeighborhoodBuilder id="z_Y9H_G210yYpgEx8T2wHw" name="Lumen_cae_Caecum_pls" description="Neighborhood between Lumen/Cecum and Mucosa/Cecum/Plasma" mode="Logical" containerType="Other" firstNeighbor="sk41NH_8KEi_nNbtDlGvFA" secondNeighbor="LGbzLR1sNEiVJUOKeIrgIw">
-              <Tags>
-                <Tag value="Neighborhood: Caecum / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="P5lKU4HaK0m4IWQgplfCbw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="v-TsGIyai0COhw3GUHIfaA" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_DrugAbsorption_para" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="kyJXZQylb0C4F9_vKHUDpw" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="x_Qkf6cl5k6AYungghO1VA" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  </Children>
-                </Container>
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="P26zhBA3R0agZNgsyNt_Kg" name="Caecum_pls_PortalVein_pls" description="Neighborhood between Cecum/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="LGbzLR1sNEiVJUOKeIrgIw" secondNeighbor="-btXNr8mOEG_8ZCjsspLow">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="zgw9JvSQ5EypkncsS2N3xQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="0Lx7cOYWbES4cANC89Ln9w" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPvePlasma" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  </Children>
-                </Container>
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="prZYW8EBDU6q5tx0LAPxsw" name="Lumen_coltrans_ColonTransversum_pls" description="Neighborhood between Lumen/Colon Transversum and Mucosa/Colon Transversum/Plasma" mode="Logical" containerType="Other" firstNeighbor="EhWe8Xqa6EKqp-YjJgQUiw" secondNeighbor="E3rvws_AOU-R8ZjRsJ7YJQ">
-              <Tags>
-                <Tag value="Neighborhood: ColonTransversum / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="c6FdX8Nb9Emm15hJtmHuDw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="qZO5zgZVKkahCP-GWH_mXw" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="ksei-au1o0qO3_MFDL4zZA" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="l-LAb9xmf0Wqoiv1rhRaBQ" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_DrugAbsorption_para" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  </Children>
-                </Container>
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="HkFBfkRb4k-SM0YHL2yJ8g" name="ColonAscendens_bc_PortalVein_bc" description="Neighborhood between Colon Ascendens/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="TJ7QlIu16kuyvAuW5cJlaA" secondNeighbor="ghMacG-81kSUPN5wkgPsnA">
-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="RY_SUpt4XEWdXJ9TI96Gfw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="2251XP5JDkyuUAZTM2pTMA" name="Mass transfer rate (mucosa to portal vein blood cells)" description="Mass transfer rate (mucosa to portal vein blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPveBloodCells" visible="0" canBeVaried="0" displayUnit="µmol/min" />
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-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
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-              <Children>
-                <Container id="2G_4TTtegkmQR5flSnuvKw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="ZTkWCQbRXUqHK5-BIABhtw" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPvePlasma" visible="0" canBeVaried="0" displayUnit="µmol/min" />
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-                </Container>
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-            <NeighborhoodBuilder id="eXscSeOK_UGshkCRjYcVGw" name="ColonSigmoid_pls_PortalVein_pls" description="Neighborhood between Colon Sigmoid/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="pJmj_UrpO0ioIgKx0SwyWg" secondNeighbor="-btXNr8mOEG_8ZCjsspLow">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
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-              <Children>
-                <Container id="X_stNndoGUWw3cZ4Qkbqjg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="GtSZNlN150uJOKQ9pukA9g" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPvePlasma" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  </Children>
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-            <NeighborhoodBuilder id="1SKKCczt6U6IXxIAASNfVQ" name="Lumen_colsigm_ColonSigmoid_cell" description="Neighborhood between Lumen/Colon Sigmoid and Mucosa/Colon Sigmoid/Intracellular" mode="Logical" containerType="Other" firstNeighbor="pXPUliiKakqWhra3psEI6A" secondNeighbor="UChU1u3Cik-a1gogAusD9g">
-              <Tags>
-                <Tag value="Neighborhood: ColonSigmoid / Intracellular" />
-              </Tags>
-              <Children>
-                <Container id="KQuA0FuYJESW-C0TGhepVQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="pAFwFZxSN0u_MxU78HiRwQ" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_DrugAbsorption_trans" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="Rm8wSkklvEWToAd8Vc7o3A" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K1" visible="0" canBeVaried="0" />
-                    <Parameter id="2NM4rUKqIky_-10UgkQADA" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_cell_lum_factor" visible="0" canBeVaried="0" />
-                    <Parameter id="d7DfnvLYvEKWfc54osHaWA" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_lum_cell_factor" visible="0" canBeVaried="0" />
-                    <Parameter id="D-EJi9d92U6TSaHDXFGuQg" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Lumen_PKSim.PARAM_K_cell_pls_ColonSigmoid" visible="0" canBeVaried="0" />
-                    <Parameter id="0saHhQPQXUa-3rS0YjdTIA" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_ColonSigmoid" visible="0" canBeVaried="1" />
-                    <Parameter id="BYu0BJACQki0HjLmqx4zLQ" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F1" visible="0" canBeVaried="0" />
-                    <Parameter id="aWsb0RstzU6PdkG9tFc0dQ" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F2" visible="0" canBeVaried="0" />
-                    <Parameter id="vcP_-2gSzESgDCdByla8jQ" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K2" visible="0" canBeVaried="0" />
-                    <Parameter id="Ka-3cTtPf0yRzvNLX-kqQg" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F3" visible="0" canBeVaried="0" />
-                    <Parameter id="LU8Zo0M8QUa5ZHd3OVVUjw" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K8" visible="0" canBeVaried="0" />
-                    <Parameter id="SRzt0xhHzkaXni7GMgMZGg" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K1" visible="0" canBeVaried="0" />
-                    <Parameter id="XHgeuBmWWE-qxURuW2hY4Q" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K3" visible="0" canBeVaried="0" />
-                    <Parameter id="tjtZBRrlb0GMVwrc9j0Prw" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K4" visible="0" canBeVaried="0" />
-                    <Parameter id="jsG73x2CnEeSWqG-l99C3w" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K5" visible="0" canBeVaried="0" />
-                    <Parameter id="BsAYGR-65k-CAhzliLkMEA" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K6" visible="0" canBeVaried="0" />
-                    <Parameter id="H4M6UKWE60-Bf_m5MoJ-vQ" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K7" visible="0" canBeVaried="0" />
-                    <Parameter id="KyRsYVGkJ0S_xH-ke3lvKw" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K8" visible="0" canBeVaried="0" />
-                    <Parameter id="gVPdumvkNUKLzS5IBmvZ6w" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F1" visible="0" canBeVaried="0" />
-                    <Parameter id="k1Ctuxk1s0605b7zGR1J6Q" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="fQYHTNRcik2Y1V73coy2gg" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F3" visible="0" canBeVaried="0" />
-                    <Parameter id="C7O6_yiXVUG0URbTWwrasg" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="pIi4ssGQ_k-ATWmQxwy3vg" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K2" visible="0" canBeVaried="0" />
-                    <Parameter id="2-m-4X6wL0OqwUkDbB3wKg" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K3" visible="0" canBeVaried="0" />
-                    <Parameter id="vH1irCkuOkCVLiOd-hL0XA" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K4" visible="0" canBeVaried="0" />
-                    <Parameter id="BzRMWeM-q0uVPKt_j0xKDg" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K5" visible="0" canBeVaried="0" />
-                    <Parameter id="htNCCj0S6U6K3Igj4QpFvg" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K6" visible="0" canBeVaried="0" />
-                    <Parameter id="Bmy-3ixqJ0S5F872kFUxZA" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K7" visible="0" canBeVaried="0" />
-                    <Parameter id="ixAs6BjE2EKPOtbRTA4zAg" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F2" visible="0" canBeVaried="0" />
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-              <Tags>
-                <Tag value="Neighborhood: ColonSigmoid / Plasma" />
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-              <Children>
-                <Container id="pVxFsD_eHkGygvfjLlZIEQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="v4kj6TKCfEuEaC7i7G38PQ" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_DrugAbsorption_para" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="H4o5zu9dckm6q7S9R3hkew" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" visible="0" canBeVaried="0" displayUnit="µmol/min" />
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-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
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-              <Children>
-                <Container id="CzQpeJJ47UCijVjTse2C-Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="7Zn0divsfU6QTdguFnVEBA" name="Mass transfer rate (mucosa to portal vein blood cells)" description="Mass transfer rate (mucosa to portal vein blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPveBloodCells" visible="0" canBeVaried="0" displayUnit="µmol/min" />
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-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
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-              <Children>
-                <Container id="byFlXNxU7UK6IoL8s-_i3g" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
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-                    <Parameter id="UyFSI4FjukiqoLWItjq6XA" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPvePlasma" visible="0" canBeVaried="0" displayUnit="µmol/min" />
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-            <NeighborhoodBuilder id="Uk6-4-vglkG7ZCZ2JOGNBg" name="ColonSigmoid_bc_PortalVein_bc" description="Neighborhood between Colon Sigmoid/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="LQuH1MHvJ0af2kvb_nXBJQ" secondNeighbor="ghMacG-81kSUPN5wkgPsnA">
-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
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-              <Children>
-                <Container id="-d9BfrDnWEGwwssALXLnUA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
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-                    <Parameter id="XsIZy6cYQkq4MB-djCmRJA" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K5" visible="0" canBeVaried="0" />
-                    <Parameter id="UpcrDDIFEUmwyeEpwCjDFg" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K4" visible="0" canBeVaried="0" />
-                    <Parameter id="9Bp2eVdySEeLEE1qjDsmOQ" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K7" visible="0" canBeVaried="0" />
-                    <Parameter id="tRkmOXNEd0icfjQYltZC0w" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K8" visible="0" canBeVaried="0" />
-                    <Parameter id="LqM1DFn6fU-gu-4ng-ghUQ" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F1" visible="0" canBeVaried="0" />
-                    <Parameter id="ChiHFNwB3Uy4d6SEBA3YAQ" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F2" visible="0" canBeVaried="0" />
-                    <Parameter id="y_EOiJcjIk-vYPbnSP69HQ" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F3" visible="0" canBeVaried="0" />
-                    <Parameter id="K7ChnYUN0E6hfCJh7ZDArA" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K1" visible="0" canBeVaried="0" />
-                    <Parameter id="0iLL4TIZEk2IMPD2-cuo9A" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K3" visible="0" canBeVaried="0" />
-                    <Parameter id="n6qkz29uj0-SKgBuS4-gYQ" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K5" visible="0" canBeVaried="0" />
-                    <Parameter id="H0cJDks-bkCbyevXabrNWQ" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K6" visible="0" canBeVaried="0" />
-                    <Parameter id="z-T0VGYlNkesNpD3LPx9qA" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K7" visible="0" canBeVaried="0" />
-                    <Parameter id="RdbnuJq7oU2P_YzwkWKhCw" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K8" visible="0" canBeVaried="0" />
-                    <Parameter id="gAsyjFGuE0qYJneIWY2EZA" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="VPhQuZ-k3U-iT3vNdGmpCA" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="su1Ka9PzA02AaQo132fnOw" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K2" visible="0" canBeVaried="0" />
-                    <Parameter id="JZsQjfjpVUWI-ZCiqrUfcg" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K4" visible="0" canBeVaried="0" />
-                    <Parameter id="2MHuI82d70SA_ShUE3iLTg" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K6" visible="0" canBeVaried="0" />
-                    <Parameter id="Xlc_tdjrokC4LGuruQg_Bg" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Lumen_PKSim.PARAM_K_cell_pls_ColonDescendens" visible="0" canBeVaried="0" />
-                    <Parameter id="ehppCDhe1E-Ps98MrK9Apw" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_DrugAbsorption_trans" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="-9dIwLVIt0umZ32IMcb0qg" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_lum_cell_factor" visible="0" canBeVaried="0" />
-                    <Parameter id="j1ytyJhN-USCfFwK_XYwpQ" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_ColonDescendens" visible="0" canBeVaried="1" />
-                    <Parameter id="-PJlASldqEmelanDtCfHiw" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F1" visible="0" canBeVaried="0" />
-                    <Parameter id="YCYA06AT_EGM01cQ86GakA" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F2" visible="0" canBeVaried="0" />
-                    <Parameter id="Gpxs5Ddx-kOM-IlTQkiNTg" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F3" visible="0" canBeVaried="0" />
-                    <Parameter id="3W8Tv00tp0eVNdKBeyAPXA" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K1" visible="0" canBeVaried="0" />
-                    <Parameter id="745RkbklQE2bNW6BqZkKjQ" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K2" visible="0" canBeVaried="0" />
-                    <Parameter id="gfTG0wpTakGPLvGJNTPgdQ" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K3" visible="0" canBeVaried="0" />
-                    <Parameter id="3M41ToZszUKUAEygEEVBug" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_cell_lum_factor" visible="0" canBeVaried="0" />
-                  </Children>
-                </Container>
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="xz7Mw7mDbEyiIA-t0J9rFw" name="Lumen_coldesc_ColonDescendens_pls" description="Neighborhood between Lumen/Colon Descendens and Mucosa/Colon Descendens/Plasma" mode="Logical" containerType="Other" firstNeighbor="TQQ1m1iJG0CQmvlfvaPkuA" secondNeighbor="xjPErKtgLE2tSY7-piU_pw">
-              <Tags>
-                <Tag value="Neighborhood: ColonDescendens / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="hfjCaS4VM0WPk_hBi9p0zw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="z0ffpsZzHUi5zDIQ2vx3gQ" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_DrugAbsorption_para" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="-zkpzoEx-UOwNf8Q2Yrtbw" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="Qq33oMDPgEKuM8VCfSGEcw" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  </Children>
-                </Container>
-              </Children>
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-            <NeighborhoodBuilder id="ChdcZU3UHka_4CdOtyAFcw" name="ColonTransversum_bc_PortalVein_bc" description="Neighborhood between Colon Transversum/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="tHA3JFaL-U-G9uaHbdHBSg" secondNeighbor="ghMacG-81kSUPN5wkgPsnA">
-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="syBQ3koY80qmN7JBdlCvKQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="0OEcTrlItUyGW5WC-Jan_Q" name="Mass transfer rate (mucosa to portal vein blood cells)" description="Mass transfer rate (mucosa to portal vein blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPveBloodCells" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  </Children>
-                </Container>
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="DMV2DP--3Em5I6GbcAcThw" name="ColonTransversum_pls_PortalVein_pls" description="Neighborhood between Colon Transversum/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="E3rvws_AOU-R8ZjRsJ7YJQ" secondNeighbor="-btXNr8mOEG_8ZCjsspLow">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="WZkd5Yi_9kGY_PO_fVio_Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="HnNzFenHYEqZldsvPFkKtQ" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPvePlasma" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  </Children>
-                </Container>
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="HafsdMMuZE2a-N_pDH2DXA" name="Lumen_coltrans_ColonTransversum_cell" description="Neighborhood between Lumen/Colon Transversum and Mucosa/Colon Transversum/Intracellular" mode="Logical" containerType="Other" firstNeighbor="EhWe8Xqa6EKqp-YjJgQUiw" secondNeighbor="VqzvPjlpO0OJvXYdR5m-rA">
-              <Tags>
-                <Tag value="Neighborhood: ColonTransversum / Intracellular" />
-              </Tags>
-              <Children>
-                <Container id="_iAwGfdFLEagNeM2OddL7Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="Q1DgvAGpNUSP_biNdeQ6-Q" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F2" visible="0" canBeVaried="0" />
-                    <Parameter id="N4fCeYWqQ0ecU0DGXEBTVg" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_DrugAbsorption_trans" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="OiwA5SIOPU-638683Qg74g" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_cell_lum_factor" visible="0" canBeVaried="0" />
-                    <Parameter id="jaiDdzLP_UOMIGBsF3NpEg" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_lum_cell_factor" visible="0" canBeVaried="0" />
-                    <Parameter id="ek4sdtQr5E-h9GVA45fUwA" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Lumen_PKSim.PARAM_K_cell_pls_ColonTransversum" visible="0" canBeVaried="0" />
-                    <Parameter id="ac7Xt6iuSEKvVwWGup3qjA" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K7" visible="0" canBeVaried="0" />
-                    <Parameter id="0FPsm5_MOEGoiGw0D2MuOw" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F1" visible="0" canBeVaried="0" />
-                    <Parameter id="tJcfFT7mmUKdjgKpEfQVhw" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F3" visible="0" canBeVaried="0" />
-                    <Parameter id="XOVuz5uALEKP3FxaJv9K0A" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K1" visible="0" canBeVaried="0" />
-                    <Parameter id="Sm417Fq0A0-XlpbUCBaq-g" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K2" visible="0" canBeVaried="0" />
-                    <Parameter id="ehU8MwtiNUaDOYGAfIT46A" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K3" visible="0" canBeVaried="0" />
-                    <Parameter id="WN-jzU8yEkytQdNz0iamlA" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K4" visible="0" canBeVaried="0" />
-                    <Parameter id="yyDBUbwmREGOLvbjfczEwg" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K5" visible="0" canBeVaried="0" />
-                    <Parameter id="mfE5HpDWDUe3Yv7kiU67ZQ" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_ColonTransversum" visible="0" canBeVaried="1" />
-                    <Parameter id="gmJ-y6U7yESC1kIY-HRywQ" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K8" visible="0" canBeVaried="0" />
-                    <Parameter id="FfdvOkCFCUC4VzfFmuxSeg" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K6" visible="0" canBeVaried="0" />
-                    <Parameter id="62YnxcJH7Eyc9Fz2uMs7dQ" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K7" visible="0" canBeVaried="0" />
-                    <Parameter id="Od9wbYpfJ0S9yk39cmbBeg" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F1" visible="0" canBeVaried="0" />
-                    <Parameter id="kLsHtNO1bU-_tTaTrRXx1Q" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F2" visible="0" canBeVaried="0" />
-                    <Parameter id="Pu-RZaunrkqo70cjjjF2DQ" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F3" visible="0" canBeVaried="0" />
-                    <Parameter id="jH3tOdVzFEaKv5PDom51Ow" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K1" visible="0" canBeVaried="0" />
-                    <Parameter id="-T6y0lG7YUe04lFSjxG3hg" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K2" visible="0" canBeVaried="0" />
-                    <Parameter id="znIPAjZelEKLII00WEIqwg" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K3" visible="0" canBeVaried="0" />
-                    <Parameter id="AHLZCETaekGV-JQQiklkmg" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K4" visible="0" canBeVaried="0" />
-                    <Parameter id="kmedmZxQbUOSf6DsyaLbPg" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K6" visible="0" canBeVaried="0" />
-                    <Parameter id="GodGOGbik0C_r_vHe8D0tw" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K8" visible="0" canBeVaried="0" />
-                    <Parameter id="ZAO2hntka0C36TBY10u85g" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="NOBFj5U1x0O5MUyKRBCHLg" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="8LGDaOz4nEWT73VCTyFmhQ" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K5" visible="0" canBeVaried="0" />
-                  </Children>
-                </Container>
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="G1QCI5vQ6k2k58iWyRuQjg" name="Lumen_colasc_ColonAscendens_cell" description="Neighborhood between Lumen/Colon Ascendens and Mucosa/Colon Ascendens/Intracellular" mode="Logical" containerType="Other" firstNeighbor="xYyLHo4Vhk6D6RJrPpFicA" secondNeighbor="_1aapd_LZk-snh-NLRJiBg">
-              <Tags>
-                <Tag value="Neighborhood: ColonAscendens / Intracellular" />
-              </Tags>
-              <Children>
-                <Container id="QJUBJ4ZEZkOU5VVJeYK6Sw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="RET_bN-ydUitCfliIQsqHA" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F2" visible="0" canBeVaried="0" />
-                    <Parameter id="67PHhCPZhkSFFMP7WSM94g" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F1" visible="0" canBeVaried="0" />
-                    <Parameter id="TMmYotbuNk6RXNDXaznO1Q" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_DrugAbsorption_trans" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="Emwct4MoOkGYYZOw3jK-Ug" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_cell_lum_factor" visible="0" canBeVaried="0" />
-                    <Parameter id="9GBcoMSjTUmO9jPWkns5uA" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_lum_cell_factor" visible="0" canBeVaried="0" />
-                    <Parameter id="be6LNm4RwE-SDOQHdNC8gw" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_ColonAscendens" visible="0" canBeVaried="1" />
-                    <Parameter id="Mi5AQsjmjkq9G2_hXlo0Fg" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F2" visible="0" canBeVaried="0" />
-                    <Parameter id="voCagoNCk0GXT5huI9myQg" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F3" visible="0" canBeVaried="0" />
-                    <Parameter id="QWTZoVx8oE2OG66uXKZtsQ" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K1" visible="0" canBeVaried="0" />
-                    <Parameter id="GjUaTFRFV0ybPJaXQkF4lA" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K2" visible="0" canBeVaried="0" />
-                    <Parameter id="3xaQsaLKFkCTRcMDVQrhLA" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K3" visible="0" canBeVaried="0" />
-                    <Parameter id="nV-jAlf9Q0eTWO34FKC8mg" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K4" visible="0" canBeVaried="0" />
-                    <Parameter id="FDNch5Zg-UCUjuJeTeVWNQ" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K5" visible="0" canBeVaried="0" />
-                    <Parameter id="4Dm8T0MSV0uvZf4FYjOthg" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K6" visible="0" canBeVaried="0" />
-                    <Parameter id="uByLt0Iy9EOF4jjX-8xmSg" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K7" visible="0" canBeVaried="0" />
-                    <Parameter id="InvLOPB5Z02_47_Kr85zEw" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K8" visible="0" canBeVaried="0" />
-                    <Parameter id="MdwImgYtVUuPnUW9n9s3pQ" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F1" visible="0" canBeVaried="0" />
-                    <Parameter id="0uQ6GexPDEapE3Kw8P-uUw" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Lumen_PKSim.PARAM_K_cell_pls_ColonAscendens" visible="0" canBeVaried="0" />
-                    <Parameter id="tdP3CH3QJUqJY5yBLFG1Ig" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F3" visible="0" canBeVaried="0" />
-                    <Parameter id="u6nORz3vjky0Y1QGY7dZAw" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="YPXfpD4vwEKHL7TFo3S4fg" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K1" visible="0" canBeVaried="0" />
-                    <Parameter id="Qv5wSIkicEaxLPBOeUx2KA" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K2" visible="0" canBeVaried="0" />
-                    <Parameter id="f2V_98czFk2hAFD2pse-pg" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K3" visible="0" canBeVaried="0" />
-                    <Parameter id="7YXpJ7vgOE2KOT39fv9UnQ" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K4" visible="0" canBeVaried="0" />
-                    <Parameter id="Fr1D0dIgME6gyJlpwb3mMg" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K5" visible="0" canBeVaried="0" />
-                    <Parameter id="dkvdWb2nZk6jBUYbl-8UNA" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K6" visible="0" canBeVaried="0" />
-                    <Parameter id="VOty3Usq9U6sFXCbAul3Cw" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K7" visible="0" canBeVaried="0" />
-                    <Parameter id="QTZzLP4KTUmAvC0IX1HIeQ" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="_jF5ErmA0EGS8n4WcTG4EA" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K8" visible="0" canBeVaried="0" />
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-            <NeighborhoodBuilder id="sq6YOuxbu0mNxeee0xBMBw" name="Lumen_colasc_ColonAscendens_pls" description="Neighborhood between Lumen/Colon Ascendens and Mucosa/Colon Ascendens/Plasma" mode="Logical" containerType="Other" firstNeighbor="xYyLHo4Vhk6D6RJrPpFicA" secondNeighbor="xNTwHCGTLkad12dHF4Jv1g">
-              <Tags>
-                <Tag value="Neighborhood: ColonAscendens / Plasma" />
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-              <Children>
-                <Container id="3pTq9sr-TkGbx_aMRqsLMw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="9EoK_Or7q0e5Ay42y8DCYA" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_DrugAbsorption_para" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="RKTJpp_HsUuNFE8hF6Nm0g" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="a7HjHBIG4EWZsEUO0L5Zng" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" visible="0" canBeVaried="0" displayUnit="µmol/min" />
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-            <NeighborhoodBuilder id="7Vz45c0ne0SKBE6eowX_nA" name="ArterialBlood_pls_Kidney_pls" description="Neighborhood between Arterial Blood/Plasma and Kidney/Plasma" mode="Logical" containerType="Other" firstNeighbor="B0yJEO0-kUqHLgCh369ADQ" secondNeighbor="vNliK8ccZ0mhuF90e6m6Sw">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="xnpBmIHtbEuN6oWeUisLyg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
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-            <NeighborhoodBuilder id="vCr_SkULYkWpf-8IEFalfw" name="ArterialBlood_pls_LargeIntestine_pls" description="Neighborhood between Arterial Blood/Plasma and Large Intestine/Plasma" mode="Logical" containerType="Other" firstNeighbor="B0yJEO0-kUqHLgCh369ADQ" secondNeighbor="pX3ccCxXKEyKOoR4QI5kRg">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="4Wsktk3tz0GYGEdBigywAQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
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-            <NeighborhoodBuilder id="gfZSHeJSC0KlSGozv7JnlQ" name="ArterialBlood_pls_Liver_pls" description="Neighborhood between Arterial Blood/Plasma and Liver/Plasma" mode="Logical" containerType="Other" firstNeighbor="B0yJEO0-kUqHLgCh369ADQ" secondNeighbor="kLQaFdxWjEyQKZou_zICsg">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="qXTbRz6UYk-9e7LIJjzdTg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
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-            <NeighborhoodBuilder id="0GRlinkOzEGk8rr0QS1vOA" name="ArterialBlood_pls_Muscle_pls" description="Neighborhood between Arterial Blood/Plasma and Muscle/Plasma" mode="Logical" containerType="Other" firstNeighbor="B0yJEO0-kUqHLgCh369ADQ" secondNeighbor="yw1lF6NGzUebqB1RzY5lcA">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
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-              <Children>
-                <Container id="SJcNRQeBgUmFr2xLtrtrQw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="ph_fNSlow02z2qdU_Dt6Tg" name="ArterialBlood_pls_Pancreas_pls" description="Neighborhood between Arterial Blood/Plasma and Pancreas/Plasma" mode="Logical" containerType="Other" firstNeighbor="B0yJEO0-kUqHLgCh369ADQ" secondNeighbor="XpMoC77tqU2dbzFapP7yNA">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="VipEed9mFU-O8a9tFVKFSw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="JOvnyeSigE2VRtMO6GYUCA" name="ArterialBlood_pls_Skin_pls" description="Neighborhood between Arterial Blood/Plasma and Skin/Plasma" mode="Logical" containerType="Other" firstNeighbor="B0yJEO0-kUqHLgCh369ADQ" secondNeighbor="WSZy9a4tjEazdIfolnG7tQ">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="9A1EseKczUmPyxuVawNDuQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="LKv-o_FXskyvyO5Z_I8EQA" name="ArterialBlood_pls_SmallIntestine_pls" description="Neighborhood between Arterial Blood/Plasma and Small Intestine/Plasma" mode="Logical" containerType="Other" firstNeighbor="B0yJEO0-kUqHLgCh369ADQ" secondNeighbor="bKNuXngQSk-SQQe7D3MkAw">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
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-              <Children>
-                <Container id="zYQwh8c9FkiJpYutpHQ2QQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
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-            <NeighborhoodBuilder id="GBqShH_arEqcH1bzZ3UAzA" name="ArterialBlood_pls_Fat_pls" description="Neighborhood between Arterial Blood/Plasma and Fat/Plasma" mode="Logical" containerType="Other" firstNeighbor="B0yJEO0-kUqHLgCh369ADQ" secondNeighbor="T_1TMJYsE0yHE_9nhhc74Q">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="7tjWuvWOd0aHq_WLal7oBA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
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-            <NeighborhoodBuilder id="PPnIesiaS0Wk_gF6pp5-4Q" name="ArterialBlood_pls_Stomach_pls" description="Neighborhood between Arterial Blood/Plasma and Stomach/Plasma" mode="Logical" containerType="Other" firstNeighbor="B0yJEO0-kUqHLgCh369ADQ" secondNeighbor="wcVwGWqUikGrxah1-6Vx6A">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="zrZBnYgUp0mSSxuyEC6jyg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
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-            <NeighborhoodBuilder id="4sODV2xbg06J3Xu51XTxXg" name="ArterialBlood_pls_Spleen_pls" description="Neighborhood between Arterial Blood/Plasma and Spleen/Plasma" mode="Logical" containerType="Other" firstNeighbor="B0yJEO0-kUqHLgCh369ADQ" secondNeighbor="K3klVlojjUGDpUNjF0hcjQ">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="FjzgJO1iMEaHyugFGYr0YQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="uKxZjEt3BEO5DhI882q-yQ" name="ArterialBlood_bc_LargeIntestine_bc" description="Neighborhood between Arterial Blood/Blood Cells and Large Intestine/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="BuQVS6yXyUaIq4-4XAWfSA" secondNeighbor="PHp1m9J9BUW9Wt4S_ZSJwQ">
-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="9bqkalSyi0KoOuBI84KGVg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="WS2q4KXm0EKCEcqDyI-8OQ" name="ArterialBlood_bc_Bone_bc" description="Neighborhood between Arterial Blood/Blood Cells and Bone/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="BuQVS6yXyUaIq4-4XAWfSA" secondNeighbor="FJ8onNQ3S0m05n8qe_e3lQ">
-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="ZHUNuArK3UKMNbpjgQjIyg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="DEU3gsE6JUmfleZ_E5locA" name="ArterialBlood_bc_Brain_bc" description="Neighborhood between Arterial Blood/Blood Cells and Brain/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="BuQVS6yXyUaIq4-4XAWfSA" secondNeighbor="-hzUSP0H0UKYFyzMVYcHLg">
-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="vsIDm_ptH0GhAOixCYMcGg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="obEQCbYaTEW6c4v-Gk-s2g" name="ArterialBlood_bc_Fat_bc" description="Neighborhood between Arterial Blood/Blood Cells and Fat/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="BuQVS6yXyUaIq4-4XAWfSA" secondNeighbor="x2EBR2z3O02CQY3uNWAaxQ">
-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="XL6z6pcIek-hsMzHSwxqLw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
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-            <NeighborhoodBuilder id="bYrMrS3mYkSEKfSfKoN_Vg" name="ArterialBlood_bc_Gonads_bc" description="Neighborhood between Arterial Blood/Blood Cells and Gonads/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="BuQVS6yXyUaIq4-4XAWfSA" secondNeighbor="lJHKHjIq9ESo-oG4BuGNgQ">
-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="HtL3aphACES6ML__BoCU1w" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="6ef_sjjTL0eCl2FYb_19rA" name="ArterialBlood_pls_Heart_pls" description="Neighborhood between Arterial Blood/Plasma and Heart/Plasma" mode="Logical" containerType="Other" firstNeighbor="B0yJEO0-kUqHLgCh369ADQ" secondNeighbor="8FF9S5dtNES_fI7J-tqAmQ">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="dNoHY-dptk-8EoXyfP81sA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="5CPndlslDUOXgsvq2NL04w" name="ArterialBlood_bc_Kidney_bc" description="Neighborhood between Arterial Blood/Blood Cells and Kidney/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="BuQVS6yXyUaIq4-4XAWfSA" secondNeighbor="8zPkGeGmU0OEOAd4v6wLwA">
-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="Oky-m-Y4q0Ks-Kx8XkoyJQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="H0s9pnu_AkGNDfp50uhWng" name="ArterialBlood_bc_Liver_bc" description="Neighborhood between Arterial Blood/Blood Cells and Liver/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="BuQVS6yXyUaIq4-4XAWfSA" secondNeighbor="yvxjl1guzkC2ZmC3cHheTA">
-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="y2bvvdQJ306BFUhT5MfqSg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="ZTtL-PzZ0kyLtXFfxD_Nfw" name="ArterialBlood_bc_Muscle_bc" description="Neighborhood between Arterial Blood/Blood Cells and Muscle/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="BuQVS6yXyUaIq4-4XAWfSA" secondNeighbor="zqX6cO98Rk-cr016qGkvtQ">
-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="Hd891GErf0K4b5R2kGQCSw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="P6zsje3aVkOY0no78WVnOg" name="ArterialBlood_bc_Pancreas_bc" description="Neighborhood between Arterial Blood/Blood Cells and Pancreas/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="BuQVS6yXyUaIq4-4XAWfSA" secondNeighbor="cE6Ep5Tc7ESxE43Touo5cw">
-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="fks34B7Cf0unPM31PGMBkQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="OT_l27vP0UqZxz4Shuf9sg" name="ArterialBlood_bc_Skin_bc" description="Neighborhood between Arterial Blood/Blood Cells and Skin/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="BuQVS6yXyUaIq4-4XAWfSA" secondNeighbor="pPMIx8esx02hUpNFp0-EDQ">
-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="ICXVefcJF0yy8YSyAP-UZA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="yAzYPz2YA0W04e-JTL744A" name="ArterialBlood_bc_SmallIntestine_bc" description="Neighborhood between Arterial Blood/Blood Cells and Small Intestine/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="BuQVS6yXyUaIq4-4XAWfSA" secondNeighbor="n6xwS0M17UWg01nLAvRLIQ">
-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="pOUN9cZYBEi43i-7lDNWBA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="FbiQqU5stkiW-4-RMXoE2Q" name="ArterialBlood_bc_Spleen_bc" description="Neighborhood between Arterial Blood/Blood Cells and Spleen/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="BuQVS6yXyUaIq4-4XAWfSA" secondNeighbor="UpAw1d6XKEShunReyqujGw">
-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="5o-gUHrOp0W51SFQUKgFNQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="2kMlxIgVOUiY3vodXiThYg" name="ArterialBlood_bc_Stomach_bc" description="Neighborhood between Arterial Blood/Blood Cells and Stomach/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="BuQVS6yXyUaIq4-4XAWfSA" secondNeighbor="ZsgRGsl2Ika6nIUVelD34g">
-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="RKIMDJJ7bUSnh6bU4q7paQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="QdZrpSkPo0mqwqW6cfWXBg" name="ArterialBlood_pls_Bone_pls" description="Neighborhood between Arterial Blood/Plasma and Bone/Plasma" mode="Logical" containerType="Other" firstNeighbor="B0yJEO0-kUqHLgCh369ADQ" secondNeighbor="5qhBG-74sEmSAgcDLdsKOw">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="8DN7nQSfGUiD5iF2RigEbg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="RmUhlxYcHUavmO4P3f4icA" name="ArterialBlood_bc_Heart_bc" description="Neighborhood between Arterial Blood/Blood Cells and Heart/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="BuQVS6yXyUaIq4-4XAWfSA" secondNeighbor="2ChqB3XlJECSWoT4xWUL4g">
-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="BVN1zQClwky7MezZDJeEsA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="NNkXB6Btk0yOtzC0XndYNQ" name="ArterialBlood_pls_Gonads_pls" description="Neighborhood between Arterial Blood/Plasma and Gonads/Plasma" mode="Logical" containerType="Other" firstNeighbor="B0yJEO0-kUqHLgCh369ADQ" secondNeighbor="WeKcMw4iF0S7FmaFEOg7rA">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="P_wqCR1ZTkOqHa25b9osAw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="RYdeMHtbM0a94Ht0ycMTbA" name="ArterialBlood_pls_Brain_pls" description="Neighborhood between Arterial Blood/Plasma and Brain/Plasma" mode="Logical" containerType="Other" firstNeighbor="B0yJEO0-kUqHLgCh369ADQ" secondNeighbor="DF7RMcQS5kelas00ZZs78w">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="erpscbQ0kEG1wT2GUcDw8Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="ZxQIzfuwOkGF8G9mxFt1Ow" name="Duodenum_bc_PortalVein_bc" description="Neighborhood between Duodenum/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="u4Ub16oEtECALrodgFre4w" secondNeighbor="ghMacG-81kSUPN5wkgPsnA">
-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="L9yEGNPLI0KAdiNbXEvsqA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="6fZw1VuNvE-FBYtS-rhwrg" name="Mass transfer rate (mucosa to portal vein blood cells)" description="Mass transfer rate (mucosa to portal vein blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPveBloodCells" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  </Children>
-                </Container>
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="X99BGpS85EOm7qXiqFMjPQ" name="Duodenum_pls_PortalVein_pls" description="Neighborhood between Duodenum/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="EkzIKZP1wU2_9u7Ncqke-Q" secondNeighbor="-btXNr8mOEG_8ZCjsspLow">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="LA8L1Id1EUioBHCdPGU2iQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="TzHGs-34k0WhrWLs3r1jEg" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPvePlasma" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  </Children>
-                </Container>
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="mGAF7JPrQES5_3do9Zei-w" name="Lumen_duo_Duodenum_cell" description="Neighborhood between Lumen/Duodenum and Mucosa/Duodenum/Intracellular" mode="Logical" containerType="Other" firstNeighbor="B2SJL0T_506x1Wlk3TTamQ" secondNeighbor="V_ZJM8cPkEqPs_Ft62p6cg">
-              <Tags>
-                <Tag value="Neighborhood: Duodenum / Intracellular" />
-              </Tags>
-              <Children>
-                <Container id="PCF_DYz-Ekm2MK94IeZu5A" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="se4T5bUP70enItiL9OiWqQ" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K7" visible="0" canBeVaried="0" />
-                    <Parameter id="QZBZ5FFF5kepzB4EmDAw4A" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K5" visible="0" canBeVaried="0" />
-                    <Parameter id="Ux9rgrPhCEqUOLFGKttASA" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K6" visible="0" canBeVaried="0" />
-                    <Parameter id="H3uM6Z51Oka8F85cQbxY-g" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K7" visible="0" canBeVaried="0" />
-                    <Parameter id="TFMmB08A60CDMxF_E8dW7g" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K8" visible="0" canBeVaried="0" />
-                    <Parameter id="T682TmjLkkeBJEy_Nw-0zA" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F1" visible="0" canBeVaried="0" />
-                    <Parameter id="FVhOykippU65XmWfNU0G0A" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F2" visible="0" canBeVaried="0" />
-                    <Parameter id="FORyMvF8CkuqCsQQbTfoUA" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F3" visible="0" canBeVaried="0" />
-                    <Parameter id="SLtVAaQ87UaNRJnlYUshTw" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K1" visible="0" canBeVaried="0" />
-                    <Parameter id="PN3OuQwHPUiYMDFqjPacVw" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K2" visible="0" canBeVaried="0" />
-                    <Parameter id="9cBQYCJudUu2prAmEunoBg" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K3" visible="0" canBeVaried="0" />
-                    <Parameter id="G3Go02fgYEWuyOU42WlFOw" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K4" visible="0" canBeVaried="0" />
-                    <Parameter id="Jm8xifho106-X9dk2nsUEQ" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K6" visible="0" canBeVaried="0" />
-                    <Parameter id="aGGX4N4MzkOGgYMds6WZAA" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K2" visible="0" canBeVaried="0" />
-                    <Parameter id="R80tN6CQt0WWn7Q0U320Dw" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K8" visible="0" canBeVaried="0" />
-                    <Parameter id="LHne2iNWgE-7RXdXWQHrgQ" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="w6ovlBtycUqSZZrvMOCBhQ" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="FmnOlk8170SDXZVlahU9wQ" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K5" visible="0" canBeVaried="0" />
-                    <Parameter id="53xbzZLk-Eirvwx7PZMhNg" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K4" visible="0" canBeVaried="0" />
-                    <Parameter id="JiQT2ybEn0Kaf4axepnxvg" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K3" visible="0" canBeVaried="0" />
-                    <Parameter id="hmp6fhTqzkq98Gi8wqkddQ" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_DrugAbsorption_trans" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="maLnrDkL602ZfYfioq5zvw" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_cell_lum_factor" visible="0" canBeVaried="0" />
-                    <Parameter id="8wGo5j3Rw0-JlTICgfZgaA" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_lum_cell_factor" visible="0" canBeVaried="0" />
-                    <Parameter id="3T-5CIO0nUCmTxaRoFvs_Q" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Lumen_PKSim.PARAM_K_cell_pls_Duodenum" visible="0" canBeVaried="0" />
-                    <Parameter id="ZuEP0zWRGEiRwnXvCLh9zg" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_Duodenum" visible="0" canBeVaried="1" />
-                    <Parameter id="b8WtOfn0KEazq1gyqDidNg" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F1" visible="0" canBeVaried="0" />
-                    <Parameter id="rMxGtxCZw0Sm3YaXe4Ws7g" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F2" visible="0" canBeVaried="0" />
-                    <Parameter id="JDa1HyJhTUqHX6boyVlh4A" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F3" visible="0" canBeVaried="0" />
-                    <Parameter id="rZ-X0x9QpUe_xqgUnN7Rqg" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K1" visible="0" canBeVaried="0" />
-                  </Children>
-                </Container>
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="BN29-Ry1H0WdSKBZLcKPow" name="Lumen_duo_Duodenum_pls" description="Neighborhood between Lumen/Duodenum and Mucosa/Duodenum/Plasma" mode="Logical" containerType="Other" firstNeighbor="B2SJL0T_506x1Wlk3TTamQ" secondNeighbor="EkzIKZP1wU2_9u7Ncqke-Q">
-              <Tags>
-                <Tag value="Neighborhood: Duodenum / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="LzEyzYCcUEGJ6z9T7dQGaA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="Vgzbh5XXRkWTsnphbD0Diw" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_DrugAbsorption_para" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="GQl8VZynnEirDu24OMCz8w" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="AM3Hs5AdAEu3vLbuBuwo_A" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  </Children>
-                </Container>
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="6AOrlhR8OkSmcDRzurDeHQ" name="ColonTransversum_cell__VenousBlood_pls" description="Neighborhood between LargeIntestine/Mucosa/ColonTransversum/Interstitial and Venous Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="OSCX1Pbj-0qKg7UUO5RmPA" secondNeighbor="AsKjCr0qtU6a-XJrIrGPTA">
-              <Tags>
-                <Tag value="Neighborhood: Interstitial / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="5ZidpamTukis0WvNDJncvw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="59Sh4plW60SIWjw4I_lE7A" name="ColonDescendens_cell__VenousBlood_pls" description="Neighborhood between LargeIntestine/Mucosa/ColonDescendens/Interstitial and Venous Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="UB8UfObHaEKIJ6imuRVB1g" secondNeighbor="AsKjCr0qtU6a-XJrIrGPTA">
-              <Tags>
-                <Tag value="Neighborhood: Interstitial / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="ktnNsSUiUEiEaUUDu5i-LQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="2GhARIfG0kaDzzRMystWvg" name="ColonSigmoid_cell__VenousBlood_pls" description="Neighborhood between LargeIntestine/Mucosa/ColonSigmoid/Interstitial and Venous Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="hmTQ2xRfwU-6I_WaFzZk6w" secondNeighbor="AsKjCr0qtU6a-XJrIrGPTA">
-              <Tags>
-                <Tag value="Neighborhood: Interstitial / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="Aj8uKP1L60mbo1dv1ETN2Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="wkUpproZe0S0jGJMllTOQw" name="Rectum_cell__VenousBlood_pls" description="Neighborhood between LargeIntestine/Mucosa/Rectum/Interstitial and Venous Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="Ske4CMSGVEmut7Tm9FygjQ" secondNeighbor="AsKjCr0qtU6a-XJrIrGPTA">
-              <Tags>
-                <Tag value="Neighborhood: Interstitial / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="Hd43sSZflUCdATyXJb9PDQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="caou7hjgEUmPzF50Rh9Ujg" name="UpperJejunum_cell__VenousBlood_pls" description="Neighborhood between SmallIntestine/Mucosa/UpperJejunum/Interstitial and Venous Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="8WvqhUtcp0qq4H3YVSDE7w" secondNeighbor="AsKjCr0qtU6a-XJrIrGPTA">
-              <Tags>
-                <Tag value="Neighborhood: Interstitial / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="CsDIW4CjJ0e7k7GnsJiIrw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="SMXHICbo20yF3K9YCHWW-w" name="ColonAscendens_cell__VenousBlood_pls" description="Neighborhood between LargeIntestine/Mucosa/ColonAscendens/Interstitial and Venous Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="NYmmlsqIWU-FZ3jqfSTfNg" secondNeighbor="AsKjCr0qtU6a-XJrIrGPTA">
-              <Tags>
-                <Tag value="Neighborhood: Interstitial / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="vhUU24CFuUmnV_-s4wafpA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              </Children>
-            </NeighborhoodBuilder>
-            <NeighborhoodBuilder id="AD9YTV-QxkO5SzP7mKz0kw" name="LowerIleum_cell__VenousBlood_pls" description="Neighborhood between SmallIntestine/Mucosa/LowerIleum/Interstitial and Venous Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="lsB27MsEJE2VZfZQB7uX0Q" secondNeighbor="AsKjCr0qtU6a-XJrIrGPTA">
-              <Tags>
-                <Tag value="Neighborhood: Interstitial / Plasma" />
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-            </Formula>
-            <Formula id="GFR_Calculation.PARAM_GFR_Spec" name="PARAM_GFR_Spec" dim="Flow per weight organ" formula="(PMA^Hill/(TM50^Hill+PMA^Hill)*(1-GFR_premat)+GFR_premat) * GFR_mat / V_kid_std">
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-              </Paths>
-            </Formula>
-            <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_kid" name="PARAM_K_Water_INT_kid" dim="Dimensionless" formula="K_water_int">
-              <Paths>
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-              </Paths>
-            </Formula>
-            <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_kid" name="PARAM_K_Water_CELL_kid" dim="Dimensionless" formula="K_water_cell">
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-            </Formula>
-            <Formula id="CompartmentsVolume_4Comp.VOLUME_LumenSegment" name="VOLUME_LumenSegment" dim="Volume" formula="PI*(r1*r1+r1*r2+r2*r2)/3*L">
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-                <Path path="231" as="232" dim="161" />
-                <Path path="233" as="234" dim="161" />
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-            </Formula>
-            <Formula id="MucosaVolume.PARAM_VolumeGutWall" name="PARAM_VolumeGutWall" dim="Volume" formula="Area*d">
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-              </Paths>
-            </Formula>
-            <Formula id="Lumen_PKSim.PARAM_pH_from_pH_fasted" name="PARAM_pH_from_pH_fasted" dim="Dimensionless" formula="pH_fasted">
-              <Paths>
-                <Path path="238" as="239" />
-              </Paths>
-            </Formula>
-            <Formula id="Lumen_PKSim.PARAM_Inflow_Stomach" name="PARAM_Inflow_Stomach" dim="Flow" formula="SteadyStateFillLevel*V/StomachInflowTime">
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-                <Path path="242" as="243" dim="177" />
-                <Path path="166" as="170" dim="51" />
-                <TimePath />
-              </Paths>
-            </Formula>
-            <Formula id="Lumen_PKSim.PARAM_FillLevelFlagFlag" name="PARAM_FillLevelFlagFlag" dim="Dimensionless" formula="(FillLevel&lt;0.9?1:1/(1+exp((FillLevel-1)/0.01)))">
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-                <Path path="244" as="245" />
-              </Paths>
-            </Formula>
-            <Formula id="Lumen_PKSim.PARAM_FillLevel" name="PARAM_FillLevel" dim="Dimensionless" formula="Liquid/V">
-              <Paths>
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-                <Path path="166" as="170" dim="51" />
-              </Paths>
-            </Formula>
-            <Formula id="Lumen_PKSim.PARAM_Area" name="PARAM_Area" dim="Area" formula="PI*(r1+r2)*L">
-              <Paths>
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-                <Path path="231" as="232" dim="161" />
-                <Path path="233" as="234" dim="161" />
-              </Paths>
-            </Formula>
-            <Formula id="Lumen_PKSim.PARAM_InverseGastricEmptyingTime" name="PARAM_InverseGastricEmptyingTime" dim="Inversed time" formula="1/GET">
-              <Paths>
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-              </Paths>
-            </Formula>
-            <Formula id="Lumen_PKSim.PARAM_Liquid_StartValue" name="PARAM_Liquid_StartValue" dim="Volume" formula="V*SteadyStateFillLevel">
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-                <Path path="166" as="170" dim="51" />
-              </Paths>
-            </Formula>
-            <Formula id="Lumen_PKSim.LiquidRHS_sto" name="LiquidRHS_sto" dim="Flow" formula="OralApplicationsEnabled ? -LT_sto + Inflow*FillLevelFlag : 0">
-              <Paths>
-                <Path path="250" as="251" />
-                <Path path="252" as="253" dim="220" />
-                <Path path="254" as="255" dim="220" />
-                <Path path="256" as="257" />
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-            </Formula>
-            <Formula id="Lumen_PKSim.PARAM_LiquidTransferRate_sto" name="PARAM_LiquidTransferRate_sto" dim="Flow" formula="w*Liquid*FillLevelFlagNext">
-              <Paths>
-                <Path path="258" as="259" dim="46" />
-                <Path path="246" as="247" dim="51" />
-                <Path path="260" as="261" />
-              </Paths>
-            </Formula>
-            <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" name="PARAM_pKa_pH_WS_lum_ForSol_K3" dim="Dimensionless" formula="F1*(1-F2)*F3">
-              <Paths>
-                <Path path="262" as="263" />
-                <Path path="264" as="265" />
-                <Path path="266" as="267" />
-              </Paths>
-            </Formula>
-            <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" name="PARAM_pKa_pH_WS_lum_ForSol_K2" dim="Dimensionless" formula="(1-F1)*F2*F3">
-              <Paths>
-                <Path path="262" as="263" />
-                <Path path="264" as="265" />
-                <Path path="266" as="267" />
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-            </Formula>
-            <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" name="PARAM_pKa_pH_WS_lum_ForSol_K1" dim="Dimensionless" formula="F1*F2*F3">
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-                <Path path="262" as="263" />
-                <Path path="264" as="265" />
-                <Path path="266" as="267" />
-              </Paths>
-            </Formula>
-            <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" name="PARAM_pKa_pH_WS_lum_ForSol_F3" dim="Dimensionless" formula="CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1">
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-                <Path path="268" as="269" />
-                <Path path="270" as="271" />
-                <Path path="272" as="273" />
-                <Path path="274" as="275" />
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-            </Formula>
-            <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" name="PARAM_pKa_pH_WS_lum_ForSol_F2" dim="Dimensionless" formula="CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1">
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-                <Path path="276" as="277" />
-                <Path path="270" as="271" />
-                <Path path="278" as="279" />
-                <Path path="274" as="275" />
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-            </Formula>
-            <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" name="PARAM_pKa_pH_WS_lum_ForSol_F1" dim="Dimensionless" formula="CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1">
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-                <Path path="280" as="281" />
-                <Path path="270" as="271" />
-                <Path path="282" as="283" />
-                <Path path="274" as="275" />
-              </Paths>
-            </Formula>
-            <Formula id="CompoundCommon.PARAM_OntogenyFactor_FromGlobal_GI" name="PARAM_OntogenyFactor_FromGlobal_GI" dim="Dimensionless" formula="f_onto">
-              <Paths>
-                <Path path="284" as="172" />
-              </Paths>
-            </Formula>
-            <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" name="PARAM_pKa_pH_WS_lum_ForSol_K5" dim="Dimensionless" formula="(1-F1)*(1-F2)*F3">
-              <Paths>
-                <Path path="262" as="263" />
-                <Path path="264" as="265" />
-                <Path path="266" as="267" />
-              </Paths>
-            </Formula>
-            <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" name="PARAM_pKa_pH_WS_lum_ForSol_K6" dim="Dimensionless" formula="(1-F1)*F2*(1-F3)">
-              <Paths>
-                <Path path="262" as="263" />
-                <Path path="264" as="265" />
-                <Path path="266" as="267" />
-              </Paths>
-            </Formula>
-            <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" name="PARAM_pKa_pH_WS_lum_ForSol_K4" dim="Dimensionless" formula="F1*F2*(1-F3)">
-              <Paths>
-                <Path path="262" as="263" />
-                <Path path="264" as="265" />
-                <Path path="266" as="267" />
-              </Paths>
-            </Formula>
-            <Formula id="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" name="PARAM_Solubility_pKa_pH_Factor" dim="Dimensionless" formula="K1+K2/base^(CT0^2)+K3/base^(CT1^2)+K4/base^(CT2^2)+K5/base^max(CT0+CT1;-CT0-CT1)+K6/base^max(CT0+CT2;-CT0-CT2)+K7/base^max(CT1+CT2;-CT1-CT2)+K8/base^max(CT0+CT1+CT2;-CT0-CT1-CT2)">
-              <Paths>
-                <Path path="285" as="286" />
-                <Path path="287" as="288" />
-                <Path path="289" as="290" />
-                <Path path="291" as="292" />
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-                <Path path="299" as="300" />
-                <Path path="280" as="281" />
-                <Path path="276" as="277" />
-                <Path path="268" as="269" />
-                <Path path="301" as="302" />
-              </Paths>
-            </Formula>
-            <Formula id="Lumen_PKSim.PARAM_IntestinalSolubility" name="PARAM_IntestinalSolubility" dim="Concentration (mass)" formula="Solubility * Solubility_pKa_REFpH_Factor / Solubility_pKa_pH_Factor">
-              <Paths>
-                <Path path="303" as="304" />
-                <Path path="305" as="306" dim="307" />
-                <Path path="308" as="309" />
-              </Paths>
-            </Formula>
-            <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" name="PARAM_pKa_pH_WS_lum_ForSol_K7" dim="Dimensionless" formula="F1*(1-F2)*(1-F3)">
-              <Paths>
-                <Path path="262" as="263" />
-                <Path path="264" as="265" />
-                <Path path="266" as="267" />
-              </Paths>
-            </Formula>
-            <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" name="PARAM_pKa_pH_WS_lum_ForSol_K8" dim="Dimensionless" formula="(1-F1)*(1-F2)*(1-F3)">
-              <Paths>
-                <Path path="262" as="263" />
-                <Path path="264" as="265" />
-                <Path path="266" as="267" />
-              </Paths>
-            </Formula>
-            <Formula id="Lumen_Geometry.PARAM_Lumen_Geometry_R1" name="PARAM_Lumen_Geometry_R1" dim="Length" formula="r1_p0 + Height*r1_p1">
-              <Paths>
-                <Path path="310" as="160" dim="161" />
-                <Path path="311" as="312" dim="161" />
-                <Path path="313" as="314" />
-              </Paths>
-            </Formula>
-            <Formula id="Lumen_PKSim.PARAM_Outflow_Duodenum" name="PARAM_Outflow_Duodenum" dim="Inversed time" formula="(k_p*alpha_p*V_p+inflow-k*alpha*V)/(alpha*V)">
-              <Paths>
-                <Path path="240" as="315" dim="20" />
-                <Path path="258" as="316" dim="46" />
-                <Path path="254" as="317" dim="220" />
-                <Path path="166" as="170" dim="51" />
-                <Path path="318" as="319" dim="20" />
-                <Path path="320" as="321" dim="46" />
-                <Path path="322" as="323" dim="51" />
-              </Paths>
-            </Formula>
-            <Formula id="Lumen_Geometry.PARAM_Lumen_Geometry_R2" name="PARAM_Lumen_Geometry_R2" dim="Length" formula="r2_p0 + Height*r2_p1">
-              <Paths>
-                <Path path="310" as="160" dim="161" />
-                <Path path="324" as="325" dim="161" />
-                <Path path="326" as="327" />
-              </Paths>
-            </Formula>
-            <Formula id="Lumen_PKSim.PARAM_InverseSITT_Factor_Duodenum" name="PARAM_InverseSITT_Factor_Duodenum" dim="Inversed time" formula="LuminalVelocity/SITT_fact">
-              <Paths>
-                <Path path="328" as="329" dim="46" />
-                <Path path="330" as="331" />
-              </Paths>
-            </Formula>
-            <Formula id="Lumen_Geometry.PARAM_Lumen_Geometry_Length" name="PARAM_Lumen_Geometry_Length" dim="Length" formula="L_p0 + Height*L_p1">
-              <Paths>
-                <Path path="310" as="160" dim="161" />
-                <Path path="332" as="333" dim="161" />
-                <Path path="334" as="335" />
-              </Paths>
-            </Formula>
-            <Formula id="Lumen_PKSim.PARAM_LiquidTransferRate_duo" name="PARAM_LiquidTransferRate_duo" dim="Flow" formula="w*Liquid*FillLevelFlagNext">
-              <Paths>
-                <Path path="258" as="259" dim="46" />
-                <Path path="246" as="247" dim="51" />
-                <Path path="336" as="261" />
-              </Paths>
-            </Formula>
-            <Formula id="Lumen_PKSim.PARAM_Inflow_Duodenum" name="PARAM_Inflow_Duodenum" dim="Flow" formula="0.02894*V">
-              <Paths>
-                <Path path="166" as="170" dim="51" />
-              </Paths>
-            </Formula>
-            <Formula id="Lumen_Geometry.PARAM_Lumen_Geometry_Thickness" name="PARAM_Lumen_Geometry_Thickness" dim="Length" formula="Thickness_p1 + Thickness_p2*(1-exp(Thickness_p3*Height))">
-              <Paths>
-                <Path path="310" as="160" dim="161" />
-                <Path path="337" as="338" dim="161" />
-                <Path path="339" as="340" dim="161" />
-                <Path path="341" as="342" dim="343" />
-              </Paths>
-            </Formula>
-            <Formula id="MucosaVolume_Human.PARAM_VolumeGutWall_Duodenum" name="PARAM_VolumeGutWall_Duodenum" dim="Volume" formula="V_Intestine * 0.087">
-              <Paths>
-                <Path path="104" as="344" dim="51" />
-              </Paths>
-            </Formula>
-            <Formula id="Lumen_PKSim.LiquidRHS_duo" name="LiquidRHS_duo" dim="Flow" formula="OralApplicationsEnabled ? LT_sto - LT_duo + Inflow*FillLevelFlag - Outflow*Liquid : 0">
-              <Paths>
-                <Path path="345" as="346" dim="46" />
-                <Path path="250" as="251" />
-                <Path path="246" as="247" dim="51" />
-                <Path path="252" as="347" dim="220" />
-                <Path path="254" as="255" dim="220" />
-                <Path path="256" as="257" />
-                <Path path="348" as="253" dim="220" />
-              </Paths>
-            </Formula>
-            <Formula id="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_duo" name="PARAM_OralMassAbsorbed_RHS_duo" dim="Amount per time" formula="PassiveRates_para+PassiveRates_trans-(ActiveRates_para+ActiveRates_trans)">
-              <Paths>
-                <Path path="349" as="350" dim="351" />
-                <Path path="352" as="353" dim="351" />
-                <Path path="354" as="355" dim="351" />
-                <Path path="356" as="357" dim="351" />
-              </Paths>
-            </Formula>
-            <Formula id="Lumen_PKSim.PARAM_LiquidTransferRate_uje" name="PARAM_LiquidTransferRate_uje" dim="Flow" formula="w*Liquid*FillLevelFlagNext">
-              <Paths>
-                <Path path="258" as="259" dim="46" />
-                <Path path="246" as="247" dim="51" />
-                <Path path="358" as="261" />
-              </Paths>
-            </Formula>
-            <Formula id="Lumen_PKSim.PARAM_Inflow_UpperJejunum" name="PARAM_Inflow_UpperJejunum" dim="Flow" formula="0.0031572*V">
-              <Paths>
-                <Path path="166" as="170" dim="51" />
-              </Paths>
-            </Formula>
-            <Formula id="MucosaVolume_Human.PARAM_VolumeGutWall_UpperJejunum" name="PARAM_VolumeGutWall_UpperJejunum" dim="Volume" formula="V_Intestine * 0.249">
-              <Paths>
-                <Path path="104" as="344" dim="51" />
-              </Paths>
-            </Formula>
-            <Formula id="Lumen_PKSim.PARAM_InverseSITT_Factor_UpperJejunum" name="PARAM_InverseSITT_Factor_UpperJejunum" dim="Inversed time" formula="LuminalVelocity/SITT_fact">
-              <Paths>
-                <Path path="328" as="329" dim="46" />
-                <Path path="330" as="331" />
-              </Paths>
-            </Formula>
-            <Formula id="Lumen_PKSim.LiquidRHS_uje" name="LiquidRHS_uje" dim="Flow" formula="OralApplicationsEnabled ? LT_duo - LT_uje + Inflow*FillLevelFlag - Outflow*Liquid : 0">
-              <Paths>
-                <Path path="345" as="346" dim="46" />
-                <Path path="250" as="251" />
-                <Path path="246" as="247" dim="51" />
-                <Path path="252" as="359" dim="220" />
-                <Path path="254" as="255" dim="220" />
-                <Path path="360" as="347" dim="220" />
-                <Path path="256" as="257" />
-              </Paths>
-            </Formula>
-            <Formula id="Lumen_PKSim.PARAM_Outflow_UpperJejunum" name="PARAM_Outflow_UpperJejunum" dim="Inversed time" formula="(k_p*alpha_p*V_p+inflow-k*alpha*V)/(alpha*V)">
-              <Paths>
-                <Path path="240" as="315" dim="20" />
-                <Path path="258" as="316" dim="46" />
-                <Path path="254" as="317" dim="220" />
-                <Path path="166" as="170" dim="51" />
-                <Path path="361" as="319" dim="20" />
-                <Path path="362" as="321" dim="46" />
-                <Path path="363" as="323" dim="51" />
-              </Paths>
-            </Formula>
-            <Formula id="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_uje" name="PARAM_OralMassAbsorbed_RHS_uje" dim="Amount per time" formula="PassiveRates_para+PassiveRates_trans-(ActiveRates_para+ActiveRates_trans)">
-              <Paths>
-                <Path path="364" as="350" dim="351" />
-                <Path path="365" as="353" dim="351" />
-                <Path path="366" as="355" dim="351" />
-                <Path path="367" as="357" dim="351" />
-              </Paths>
-            </Formula>
-            <Formula id="MucosaVolume_Human.PARAM_VolumeGutWall_LowerJejunum" name="PARAM_VolumeGutWall_LowerJejunum" dim="Volume" formula="V_Intestine * 0.184">
-              <Paths>
-                <Path path="104" as="344" dim="51" />
-              </Paths>
-            </Formula>
-            <Formula id="Lumen_PKSim.PARAM_Outflow_LowerJejunum" name="PARAM_Outflow_LowerJejunum" dim="Inversed time" formula="(k_p*alpha_p*V_p+inflow-k*alpha*V)/(alpha*V)">
-              <Paths>
-                <Path path="240" as="315" dim="20" />
-                <Path path="258" as="316" dim="46" />
-                <Path path="254" as="317" dim="220" />
-                <Path path="166" as="170" dim="51" />
-                <Path path="368" as="319" dim="20" />
-                <Path path="369" as="321" dim="46" />
-                <Path path="370" as="323" dim="51" />
-              </Paths>
-            </Formula>
-            <Formula id="Lumen_PKSim.PARAM_InverseSITT_Factor_LowerJejunum" name="PARAM_InverseSITT_Factor_LowerJejunum" dim="Inversed time" formula="LuminalVelocity/SITT_fact">
-              <Paths>
-                <Path path="328" as="329" dim="46" />
-                <Path path="330" as="331" />
-              </Paths>
-            </Formula>
-            <Formula id="Lumen_PKSim.LiquidRHS_lje" name="LiquidRHS_lje" dim="Flow" formula="OralApplicationsEnabled ? LT_uje - LT_lje + Inflow*FillLevelFlag - Outflow*Liquid : 0">
-              <Paths>
-                <Path path="345" as="346" dim="46" />
-                <Path path="250" as="251" />
-                <Path path="246" as="247" dim="51" />
-                <Path path="252" as="371" dim="220" />
-                <Path path="254" as="255" dim="220" />
-                <Path path="372" as="359" dim="220" />
-                <Path path="256" as="257" />
-              </Paths>
-            </Formula>
-            <Formula id="Lumen_PKSim.PARAM_LiquidTransferRate_lje" name="PARAM_LiquidTransferRate_lje" dim="Flow" formula="w*Liquid*FillLevelFlagNext">
-              <Paths>
-                <Path path="258" as="259" dim="46" />
-                <Path path="246" as="247" dim="51" />
-                <Path path="373" as="261" />
-              </Paths>
-            </Formula>
-            <Formula id="Lumen_PKSim.PARAM_Inflow_LowerJejunum" name="PARAM_Inflow_LowerJejunum" dim="Flow" formula="0.0025102*V">
-              <Paths>
-                <Path path="166" as="170" dim="51" />
-              </Paths>
-            </Formula>
-            <Formula id="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_lje" name="PARAM_OralMassAbsorbed_RHS_lje" dim="Amount per time" formula="PassiveRates_para+PassiveRates_trans-(ActiveRates_para+ActiveRates_trans)">
-              <Paths>
-                <Path path="374" as="350" dim="351" />
-                <Path path="375" as="353" dim="351" />
-                <Path path="376" as="355" dim="351" />
-                <Path path="377" as="357" dim="351" />
-              </Paths>
-            </Formula>
-            <Formula id="Lumen_PKSim.PARAM_Inflow_UpperIleum" name="PARAM_Inflow_UpperIleum" dim="Flow" formula="0.0029585*V">
-              <Paths>
-                <Path path="166" as="170" dim="51" />
-              </Paths>
-            </Formula>
-            <Formula id="Lumen_PKSim.PARAM_Outflow_UpperIleum" name="PARAM_Outflow_UpperIleum" dim="Inversed time" formula="(k_p*alpha_p*V_p+inflow-k*alpha*V)/(alpha*V)">
-              <Paths>
-                <Path path="240" as="315" dim="20" />
-                <Path path="258" as="316" dim="46" />
-                <Path path="254" as="317" dim="220" />
-                <Path path="166" as="170" dim="51" />
-                <Path path="378" as="319" dim="20" />
-                <Path path="379" as="321" dim="46" />
-                <Path path="380" as="323" dim="51" />
-              </Paths>
-            </Formula>
-            <Formula id="Lumen_PKSim.PARAM_InverseSITT_Factor_UpperIleum" name="PARAM_InverseSITT_Factor_UpperIleum" dim="Inversed time" formula="LuminalVelocity/SITT_fact">
-              <Paths>
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-                <Path path="330" as="331" />
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-            </Formula>
-            <Formula id="Lumen_PKSim.LiquidRHS_uil" name="LiquidRHS_uil" dim="Flow" formula="OralApplicationsEnabled ? LT_lje - LT_uil + Inflow*FillLevelFlag - Outflow*Liquid : 0">
-              <Paths>
-                <Path path="345" as="346" dim="46" />
-                <Path path="250" as="251" />
-                <Path path="246" as="247" dim="51" />
-                <Path path="252" as="381" dim="220" />
-                <Path path="254" as="255" dim="220" />
-                <Path path="382" as="371" dim="220" />
-                <Path path="256" as="257" />
-              </Paths>
-            </Formula>
-            <Formula id="MucosaVolume_Human.PARAM_VolumeGutWall_UpperIleum" name="PARAM_VolumeGutWall_UpperIleum" dim="Volume" formula="V_Intestine * 0.324">
-              <Paths>
-                <Path path="104" as="344" dim="51" />
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-            </Formula>
-            <Formula id="Lumen_PKSim.PARAM_LiquidTransferRate_uil" name="PARAM_LiquidTransferRate_uil" dim="Flow" formula="w*Liquid*FillLevelFlagNext">
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-                <Path path="258" as="259" dim="46" />
-                <Path path="246" as="247" dim="51" />
-                <Path path="383" as="261" />
-              </Paths>
-            </Formula>
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-                <Path path="385" as="353" dim="351" />
-                <Path path="386" as="355" dim="351" />
-                <Path path="387" as="357" dim="351" />
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-            </Formula>
-            <Formula id="Lumen_PKSim.PARAM_Outflow_LowerIleum" name="PARAM_Outflow_LowerIleum" dim="Inversed time" formula="(k_p*alpha_p*V_p+inflow-k*alpha*V)/(alpha*V)">
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-                <Path path="240" as="315" dim="20" />
-                <Path path="258" as="316" dim="46" />
-                <Path path="254" as="317" dim="220" />
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-                <Path path="388" as="319" dim="20" />
-                <Path path="389" as="321" dim="46" />
-                <Path path="390" as="323" dim="51" />
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-            </Formula>
-            <Formula id="Lumen_PKSim.PARAM_InverseSITT_Factor_LowerIleum" name="PARAM_InverseSITT_Factor_LowerIleum" dim="Inversed time" formula="LuminalVelocity/SITT_fact">
-              <Paths>
-                <Path path="328" as="329" dim="46" />
-                <Path path="330" as="331" />
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-            </Formula>
-            <Formula id="Lumen_PKSim.LiquidRHS_lil" name="LiquidRHS_lil" dim="Flow" formula="OralApplicationsEnabled ? LT_uil - LT_lil + Inflow*FillLevelFlag - Outflow*Liquid : 0">
-              <Paths>
-                <Path path="345" as="346" dim="46" />
-                <Path path="250" as="251" />
-                <Path path="246" as="247" dim="51" />
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-                <Path path="254" as="255" dim="220" />
-                <Path path="392" as="381" dim="220" />
-                <Path path="256" as="257" />
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-            </Formula>
-            <Formula id="Lumen_PKSim.PARAM_LiquidTransferRate_lil" name="PARAM_LiquidTransferRate_lil" dim="Flow" formula="w*Liquid*FillLevelFlagNext">
-              <Paths>
-                <Path path="258" as="259" dim="46" />
-                <Path path="246" as="247" dim="51" />
-                <Path path="393" as="261" />
-              </Paths>
-            </Formula>
-            <Formula id="Lumen_PKSim.PARAM_Inflow_LowerIleum" name="PARAM_Inflow_LowerIleum" dim="Flow" formula="0.0017657*V">
-              <Paths>
-                <Path path="166" as="170" dim="51" />
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-            </Formula>
-            <Formula id="MucosaVolume_Human.PARAM_VolumeGutWall_LowerIleum" name="PARAM_VolumeGutWall_LowerIleum" dim="Volume" formula="V_Intestine * 0.156">
-              <Paths>
-                <Path path="104" as="344" dim="51" />
-              </Paths>
-            </Formula>
-            <Formula id="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_lil" name="PARAM_OralMassAbsorbed_RHS_lil" dim="Amount per time" formula="PassiveRates_para+PassiveRates_trans-(ActiveRates_para+ActiveRates_trans)">
-              <Paths>
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-                <Path path="395" as="353" dim="351" />
-                <Path path="396" as="355" dim="351" />
-                <Path path="397" as="357" dim="351" />
-              </Paths>
-            </Formula>
-            <Formula id="MucosaVolume_Human.PARAM_VolumeGutWall_Caecum" name="PARAM_VolumeGutWall_Caecum" dim="Volume" formula="V_Intestine * 0.08470588">
-              <Paths>
-                <Path path="78" as="344" dim="51" />
-              </Paths>
-            </Formula>
-            <Formula id="Lumen_PKSim.PARAM_Outflow_Caecum" name="PARAM_Outflow_Caecum" dim="Inversed time" formula="(k_p*alpha_p*V_p+inflow-k*alpha*V)/(alpha*V)">
-              <Paths>
-                <Path path="240" as="315" dim="20" />
-                <Path path="258" as="316" dim="46" />
-                <Path path="254" as="317" dim="220" />
-                <Path path="166" as="170" dim="51" />
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-                <Path path="399" as="321" dim="46" />
-                <Path path="400" as="323" dim="51" />
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-            </Formula>
-            <Formula id="Lumen_PKSim.PARAM_InverseLITT_Factor_Caecum" name="PARAM_InverseLITT_Factor_Caecum" dim="Inversed time" formula="LuminalVelocity/LITT_fact">
-              <Paths>
-                <Path path="328" as="329" dim="46" />
-                <Path path="401" as="402" />
-              </Paths>
-            </Formula>
-            <Formula id="Lumen_PKSim.LiquidRHS_cae" name="LiquidRHS_cae" dim="Flow" formula="OralApplicationsEnabled ? LT_lil - LT_cae + Inflow*FillLevelFlag - Outflow*Liquid : 0">
-              <Paths>
-                <Path path="345" as="346" dim="46" />
-                <Path path="250" as="251" />
-                <Path path="246" as="247" dim="51" />
-                <Path path="252" as="403" dim="220" />
-                <Path path="254" as="255" dim="220" />
-                <Path path="404" as="391" dim="220" />
-                <Path path="256" as="257" />
-              </Paths>
-            </Formula>
-            <Formula id="Lumen_PKSim.PARAM_LiquidTransferRate_cae" name="PARAM_LiquidTransferRate_cae" dim="Flow" formula="w*Liquid*FillLevelFlagNext">
-              <Paths>
-                <Path path="258" as="259" dim="46" />
-                <Path path="246" as="247" dim="51" />
-                <Path path="405" as="261" />
-              </Paths>
-            </Formula>
-            <Formula id="Lumen_PKSim.PARAM_Inflow_Caecum" name="PARAM_Inflow_Caecum" dim="Flow" formula="0*V">
-              <Paths>
-                <Path path="166" as="170" dim="51" />
-              </Paths>
-            </Formula>
-            <Formula id="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_cae" name="PARAM_OralMassAbsorbed_RHS_cae" dim="Amount per time" formula="PassiveRates_para+PassiveRates_trans-(ActiveRates_para+ActiveRates_trans)">
-              <Paths>
-                <Path path="406" as="350" dim="351" />
-                <Path path="407" as="353" dim="351" />
-                <Path path="408" as="355" dim="351" />
-                <Path path="409" as="357" dim="351" />
-              </Paths>
-            </Formula>
-            <Formula id="Lumen_PKSim.PARAM_Outflow_ColonAscendens" name="PARAM_Outflow_ColonAscendens" dim="Inversed time" formula="(k_p*alpha_p*V_p+inflow-k*alpha*V)/(alpha*V)">
-              <Paths>
-                <Path path="240" as="315" dim="20" />
-                <Path path="258" as="316" dim="46" />
-                <Path path="254" as="317" dim="220" />
-                <Path path="166" as="170" dim="51" />
-                <Path path="410" as="319" dim="20" />
-                <Path path="411" as="321" dim="46" />
-                <Path path="412" as="323" dim="51" />
-              </Paths>
-            </Formula>
-            <Formula id="Lumen_PKSim.PARAM_InverseLITT_Factor_ColonAscendens" name="PARAM_InverseLITT_Factor_ColonAscendens" dim="Inversed time" formula="LuminalVelocity/LITT_fact">
-              <Paths>
-                <Path path="328" as="329" dim="46" />
-                <Path path="401" as="402" />
-              </Paths>
-            </Formula>
-            <Formula id="Lumen_PKSim.LiquidRHS_colasc" name="LiquidRHS_colasc" dim="Flow" formula="OralApplicationsEnabled ? LT_cae - LT_colasc + Inflow*FillLevelFlag - Outflow*Liquid : 0">
-              <Paths>
-                <Path path="345" as="346" dim="46" />
-                <Path path="250" as="251" />
-                <Path path="246" as="247" dim="51" />
-                <Path path="252" as="413" dim="220" />
-                <Path path="254" as="255" dim="220" />
-                <Path path="414" as="403" dim="220" />
-                <Path path="256" as="257" />
-              </Paths>
-            </Formula>
-            <Formula id="Lumen_PKSim.PARAM_LiquidTransferRate_colasc" name="PARAM_LiquidTransferRate_colasc" dim="Flow" formula="w*Liquid*FillLevelFlagNext">
-              <Paths>
-                <Path path="258" as="259" dim="46" />
-                <Path path="246" as="247" dim="51" />
-                <Path path="415" as="261" />
-              </Paths>
-            </Formula>
-            <Formula id="Lumen_PKSim.PARAM_Inflow_ColonAscendens" name="PARAM_Inflow_ColonAscendens" dim="Flow" formula="0.00098426*V">
-              <Paths>
-                <Path path="166" as="170" dim="51" />
-              </Paths>
-            </Formula>
-            <Formula id="MucosaVolume_Human.PARAM_VolumeGutWall_ColonAscendens" name="PARAM_VolumeGutWall_ColonAscendens" dim="Volume" formula="V_Intestine * 0.15529412">
-              <Paths>
-                <Path path="78" as="344" dim="51" />
-              </Paths>
-            </Formula>
-            <Formula id="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_colasc" name="PARAM_OralMassAbsorbed_RHS_colasc" dim="Amount per time" formula="PassiveRates_para+PassiveRates_trans-(ActiveRates_para+ActiveRates_trans)">
-              <Paths>
-                <Path path="416" as="350" dim="351" />
-                <Path path="417" as="353" dim="351" />
-                <Path path="418" as="355" dim="351" />
-                <Path path="419" as="357" dim="351" />
-              </Paths>
-            </Formula>
-            <Formula id="Lumen_PKSim.PARAM_LiquidTransferRate_coltrans" name="PARAM_LiquidTransferRate_coltrans" dim="Flow" formula="w*Liquid*FillLevelFlagNext">
-              <Paths>
-                <Path path="258" as="259" dim="46" />
-                <Path path="246" as="247" dim="51" />
-                <Path path="420" as="261" />
-              </Paths>
-            </Formula>
-            <Formula id="Lumen_PKSim.PARAM_Inflow_ColonTransversum" name="PARAM_Inflow_ColonTransversum" dim="Flow" formula="0.00020285*V">
-              <Paths>
-                <Path path="166" as="170" dim="51" />
-              </Paths>
-            </Formula>
-            <Formula id="MucosaVolume_Human.PARAM_VolumeGutWall_ColonTransversum" name="PARAM_VolumeGutWall_ColonTransversum" dim="Volume" formula="V_Intestine * 0.32">
-              <Paths>
-                <Path path="78" as="344" dim="51" />
-              </Paths>
-            </Formula>
-            <Formula id="Lumen_PKSim.PARAM_InverseLITT_Factor_ColonTransversum" name="PARAM_InverseLITT_Factor_ColonTransversum" dim="Inversed time" formula="LuminalVelocity/LITT_fact">
-              <Paths>
-                <Path path="328" as="329" dim="46" />
-                <Path path="401" as="402" />
-              </Paths>
-            </Formula>
-            <Formula id="Lumen_PKSim.LiquidRHS_coltrans" name="LiquidRHS_coltrans" dim="Flow" formula="OralApplicationsEnabled ? LT_colasc - LT_coltrans + Inflow*FillLevelFlag - Outflow*Liquid : 0">
-              <Paths>
-                <Path path="345" as="346" dim="46" />
-                <Path path="250" as="251" />
-                <Path path="246" as="247" dim="51" />
-                <Path path="252" as="421" dim="220" />
-                <Path path="254" as="255" dim="220" />
-                <Path path="422" as="413" dim="220" />
-                <Path path="256" as="257" />
-              </Paths>
-            </Formula>
-            <Formula id="Lumen_PKSim.PARAM_Outflow_ColonTransversum" name="PARAM_Outflow_ColonTransversum" dim="Inversed time" formula="(k_p*alpha_p*V_p+inflow-k*alpha*V)/(alpha*V)">
-              <Paths>
-                <Path path="240" as="315" dim="20" />
-                <Path path="258" as="316" dim="46" />
-                <Path path="254" as="317" dim="220" />
-                <Path path="166" as="170" dim="51" />
-                <Path path="423" as="319" dim="20" />
-                <Path path="424" as="321" dim="46" />
-                <Path path="425" as="323" dim="51" />
-              </Paths>
-            </Formula>
-            <Formula id="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_coltrans" name="PARAM_OralMassAbsorbed_RHS_coltrans" dim="Amount per time" formula="PassiveRates_para+PassiveRates_trans-(ActiveRates_para+ActiveRates_trans)">
-              <Paths>
-                <Path path="426" as="350" dim="351" />
-                <Path path="427" as="353" dim="351" />
-                <Path path="428" as="355" dim="351" />
-                <Path path="429" as="357" dim="351" />
-              </Paths>
-            </Formula>
-            <Formula id="MucosaVolume_Human.PARAM_VolumeGutWall_ColonDescendens" name="PARAM_VolumeGutWall_ColonDescendens" dim="Volume" formula="V_Intestine * 0.24">
-              <Paths>
-                <Path path="78" as="344" dim="51" />
-              </Paths>
-            </Formula>
-            <Formula id="Lumen_PKSim.PARAM_InverseLITT_Factor_ColonDescendens" name="PARAM_InverseLITT_Factor_ColonDescendens" dim="Inversed time" formula="LuminalVelocity/LITT_fact">
-              <Paths>
-                <Path path="328" as="329" dim="46" />
-                <Path path="401" as="402" />
-              </Paths>
-            </Formula>
-            <Formula id="Lumen_PKSim.LiquidRHS_coldesc" name="LiquidRHS_coldesc" dim="Flow" formula="OralApplicationsEnabled ? LT_coltrans - LT_coldesc + Inflow*FillLevelFlag - Outflow*Liquid : 0">
-              <Paths>
-                <Path path="345" as="346" dim="46" />
-                <Path path="250" as="251" />
-                <Path path="246" as="247" dim="51" />
-                <Path path="252" as="430" dim="220" />
-                <Path path="254" as="255" dim="220" />
-                <Path path="431" as="421" dim="220" />
-                <Path path="256" as="257" />
-              </Paths>
-            </Formula>
-            <Formula id="Lumen_PKSim.PARAM_LiquidTransferRate_coldesc" name="PARAM_LiquidTransferRate_coldesc" dim="Flow" formula="w*Liquid*FillLevelFlagNext">
-              <Paths>
-                <Path path="258" as="259" dim="46" />
-                <Path path="246" as="247" dim="51" />
-                <Path path="432" as="261" />
-              </Paths>
-            </Formula>
-            <Formula id="Lumen_PKSim.PARAM_Inflow_ColonDescendens" name="PARAM_Inflow_ColonDescendens" dim="Flow" formula="0.00023004*V">
-              <Paths>
-                <Path path="166" as="170" dim="51" />
-              </Paths>
-            </Formula>
-            <Formula id="Lumen_PKSim.PARAM_Outflow_ColonDescendens" name="PARAM_Outflow_ColonDescendens" dim="Inversed time" formula="(k_p*alpha_p*V_p+inflow-k*alpha*V)/(alpha*V)">
-              <Paths>
-                <Path path="240" as="315" dim="20" />
-                <Path path="258" as="316" dim="46" />
-                <Path path="254" as="317" dim="220" />
-                <Path path="166" as="170" dim="51" />
-                <Path path="433" as="319" dim="20" />
-                <Path path="434" as="321" dim="46" />
-                <Path path="435" as="323" dim="51" />
-              </Paths>
-            </Formula>
-            <Formula id="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_coldesc" name="PARAM_OralMassAbsorbed_RHS_coldesc" dim="Amount per time" formula="PassiveRates_para+PassiveRates_trans-(ActiveRates_para+ActiveRates_trans)">
-              <Paths>
-                <Path path="436" as="350" dim="351" />
-                <Path path="437" as="353" dim="351" />
-                <Path path="438" as="355" dim="351" />
-                <Path path="439" as="357" dim="351" />
-              </Paths>
-            </Formula>
-            <Formula id="Lumen_PKSim.PARAM_Outflow_ColonSigmoid" name="PARAM_Outflow_ColonSigmoid" dim="Inversed time" formula="(k_p*alpha_p*V_p+inflow-k*alpha*V)/(alpha*V)">
-              <Paths>
-                <Path path="240" as="315" dim="20" />
-                <Path path="258" as="316" dim="46" />
-                <Path path="254" as="317" dim="220" />
-                <Path path="166" as="170" dim="51" />
-                <Path path="440" as="319" dim="20" />
-                <Path path="441" as="321" dim="46" />
-                <Path path="442" as="323" dim="51" />
-              </Paths>
-            </Formula>
-            <Formula id="Lumen_PKSim.PARAM_InverseLITT_Factor_ColonSigmoid" name="PARAM_InverseLITT_Factor_ColonSigmoid" dim="Inversed time" formula="LuminalVelocity/LITT_fact">
-              <Paths>
-                <Path path="328" as="329" dim="46" />
-                <Path path="401" as="402" />
-              </Paths>
-            </Formula>
-            <Formula id="Lumen_PKSim.LiquidRHS_colsigm" name="LiquidRHS_colsigm" dim="Flow" formula="OralApplicationsEnabled ? LT_coldesc - LT_colsigm + Inflow*FillLevelFlag - Outflow*Liquid : 0">
-              <Paths>
-                <Path path="345" as="346" dim="46" />
-                <Path path="250" as="251" />
-                <Path path="246" as="247" dim="51" />
-                <Path path="252" as="443" dim="220" />
-                <Path path="254" as="255" dim="220" />
-                <Path path="444" as="430" dim="220" />
-                <Path path="256" as="257" />
-              </Paths>
-            </Formula>
-            <Formula id="Lumen_PKSim.PARAM_LiquidTransferRate_colsigm" name="PARAM_LiquidTransferRate_colsigm" dim="Flow" formula="w*Liquid*FillLevelFlagNext">
-              <Paths>
-                <Path path="258" as="259" dim="46" />
-                <Path path="246" as="247" dim="51" />
-                <Path path="445" as="261" />
-              </Paths>
-            </Formula>
-            <Formula id="MucosaVolume_Human.PARAM_VolumeGutWall_ColonSigmoid" name="PARAM_VolumeGutWall_ColonSigmoid" dim="Volume" formula="V_Intestine * 0.135">
-              <Paths>
-                <Path path="78" as="344" dim="51" />
-              </Paths>
-            </Formula>
-            <Formula id="Lumen_PKSim.PARAM_Inflow_ColonSigmoid" name="PARAM_Inflow_ColonSigmoid" dim="Flow" formula="0.00013099*V">
-              <Paths>
-                <Path path="166" as="170" dim="51" />
-              </Paths>
-            </Formula>
-            <Formula id="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_colsigm" name="PARAM_OralMassAbsorbed_RHS_colsigm" dim="Amount per time" formula="PassiveRates_para+PassiveRates_trans-(ActiveRates_para+ActiveRates_trans)">
-              <Paths>
-                <Path path="446" as="350" dim="351" />
-                <Path path="447" as="353" dim="351" />
-                <Path path="448" as="355" dim="351" />
-                <Path path="449" as="357" dim="351" />
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-            </Formula>
-            <Formula id="Lumen_PKSim.PARAM_Outflow_Rectum" name="PARAM_Outflow_Rectum" dim="Inversed time" formula="(k_p*alpha_p*V_p+inflow-k*alpha*V)/(alpha*V)">
-              <Paths>
-                <Path path="240" as="315" dim="20" />
-                <Path path="258" as="316" dim="46" />
-                <Path path="254" as="317" dim="220" />
-                <Path path="166" as="170" dim="51" />
-                <Path path="450" as="319" dim="20" />
-                <Path path="451" as="321" dim="46" />
-                <Path path="452" as="323" dim="51" />
-              </Paths>
-            </Formula>
-            <Formula id="Lumen_PKSim.LiquidRHS_rect" name="LiquidRHS_rect" dim="Flow" formula="OralApplicationsEnabled ? LT_colsigm - LT_rect + Inflow*FillLevelFlag : 0">
-              <Paths>
-                <Path path="250" as="251" />
-                <Path path="252" as="453" dim="220" />
-                <Path path="254" as="255" dim="220" />
-                <Path path="454" as="443" dim="220" />
-                <Path path="256" as="257" />
-              </Paths>
-            </Formula>
-            <Formula id="Lumen_PKSim.PARAM_InverseLITT_Factor_Rectum" name="PARAM_InverseLITT_Factor_Rectum" dim="Inversed time" formula="LuminalVelocity/LITT_fact">
-              <Paths>
-                <Path path="328" as="329" dim="46" />
-                <Path path="401" as="402" />
-              </Paths>
-            </Formula>
-            <Formula id="Lumen_PKSim.PARAM_LiquidTransferRate_rect" name="PARAM_LiquidTransferRate_rect" dim="Flow" formula="w*Liquid">
-              <Paths>
-                <Path path="258" as="259" dim="46" />
-                <Path path="246" as="247" dim="51" />
-              </Paths>
-            </Formula>
-            <Formula id="Lumen_PKSim.PARAM_Inflow_Rectum" name="PARAM_Inflow_Rectum" dim="Flow" formula="0.00071247*V">
-              <Paths>
-                <Path path="166" as="170" dim="51" />
-              </Paths>
-            </Formula>
-            <Formula id="MucosaVolume_Human.PARAM_VolumeGutWall_Rectum" name="PARAM_VolumeGutWall_Rectum" dim="Volume" formula="V_Intestine * 0.055">
-              <Paths>
-                <Path path="78" as="344" dim="51" />
-              </Paths>
-            </Formula>
-            <Formula id="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_rect" name="PARAM_OralMassAbsorbed_RHS_rect" dim="Amount per time" formula="PassiveRates_para+PassiveRates_trans-(ActiveRates_para+ActiveRates_trans)">
-              <Paths>
-                <Path path="455" as="350" dim="351" />
-                <Path path="456" as="353" dim="351" />
-                <Path path="457" as="355" dim="351" />
-                <Path path="458" as="357" dim="351" />
-              </Paths>
-            </Formula>
-            <Formula id="Lumen_PKSim.LiquidRHS_fec" name="LiquidRHS_fec" dim="Flow" formula="OralApplicationsEnabled ? LT_rec : 0">
-              <Paths>
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-                <Path path="256" as="257" />
-              </Paths>
-            </Formula>
-            <Formula id="VascularEndoVolume.VOLUME_VascularEndo_sto" name="VOLUME_VascularEndo_sto" dim="Volume" formula="SA_pls_int*d_endo">
-              <Paths>
-                <Path path="183" as="184" dim="161" />
-                <Path path="461" as="186" dim="187" />
-              </Paths>
-            </Formula>
-            <Formula id="Individual_PKSim.PARAM_Lymph_flow_rate_Stomach" name="PARAM_Lymph_flow_rate_Stomach" dim="Flow" formula="0.000000066*BW/0.02">
-              <Paths>
-                <Path path="162" as="163" dim="118" />
-              </Paths>
-            </Formula>
-            <Formula id="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate_Stomach" name="PARAM_Fluid_recirculation_flow_rate_Stomach" dim="Flow" formula="0.00000000543*(BW/0.02)^0.75">
-              <Paths>
-                <Path path="162" as="163" dim="118" />
-              </Paths>
-            </Formula>
-            <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_sto" name="PARAM_K_Water_INT_sto" dim="Dimensionless" formula="K_water_int">
-              <Paths>
-                <Path path="462" as="196" />
-              </Paths>
-            </Formula>
-            <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_sto" name="PARAM_K_Water_CELL_sto" dim="Dimensionless" formula="K_water_cell">
-              <Paths>
-                <Path path="463" as="200" />
-              </Paths>
-            </Formula>
-            <Formula id="Lumen_PKSim.PARAM_SITT_Factor" name="PARAM_SITT_Factor" dim="Dimensionless" formula="P1*SITT+P2">
-              <Paths>
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-                <Path path="466" as="467" />
-                <Path path="468" as="469" dim="46" />
-              </Paths>
-            </Formula>
-            <Formula id="Individual_PKSim.PARAM_Q_Lymph_sin" name="PARAM_Q_Lymph_sin" dim="Flow" formula="Q_lymph_incl_Mucosa-Q_lymph_duo-Q_lymph_uje-Q_lymph_lje-Q_lymph_uil-Q_lymph_lil">
-              <Paths>
-                <Path path="470" as="471" dim="220" />
-                <Path path="472" as="473" dim="220" />
-                <Path path="474" as="475" dim="220" />
-                <Path path="476" as="477" dim="220" />
-                <Path path="478" as="479" dim="220" />
-                <Path path="480" as="481" dim="220" />
-              </Paths>
-            </Formula>
-            <Formula id="VascularEndoVolume.VOLUME_VascularEndo_sin" name="VOLUME_VascularEndo_sin" dim="Volume" formula="SA_pls_int*d_endo">
-              <Paths>
-                <Path path="183" as="184" dim="161" />
-                <Path path="482" as="186" dim="187" />
-              </Paths>
-            </Formula>
-            <Formula id="Individual_PKSim.PARAM_Lymph_flow_rate_(incl._mucosa)_SmallIntestine" name="PARAM_Lymph_flow_rate_(incl._mucosa)_SmallIntestine" dim="Flow" formula="0.00000012*BW/0.02">
-              <Paths>
-                <Path path="162" as="163" dim="118" />
-              </Paths>
-            </Formula>
-            <Formula id="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate_(incl._mucosa)_SmallIntestine" name="PARAM_Fluid_recirculation_flow_rate_(incl._mucosa)_SmallIntestine" dim="Flow" formula="0.00000000421*(BW/0.02)^0.75">
-              <Paths>
-                <Path path="162" as="163" dim="118" />
-              </Paths>
-            </Formula>
-            <Formula id="Individual_PKSim.PARAM_FluidRecirculationRate_sin" name="PARAM_FluidRecirculationRate_sin" dim="Flow" formula="J_iso_incl_Mucosa-J_iso_duo-J_iso_uje-J_iso_lje-J_iso_uil-J_iso_lil">
-              <Paths>
-                <Path path="483" as="484" dim="220" />
-                <Path path="485" as="486" dim="220" />
-                <Path path="487" as="488" dim="220" />
-                <Path path="489" as="490" dim="220" />
-                <Path path="491" as="492" dim="220" />
-                <Path path="493" as="494" dim="220" />
-              </Paths>
-            </Formula>
-            <Formula id="MucosaVolume.VOLUME_SmallIntestineMucosa" name="VOLUME_SmallIntestineMucosa" dim="Volume" formula="V_duo+V_uje+V_lje+V_uil+V_lil">
-              <Paths>
-                <Path path="495" as="496" dim="51" />
-                <Path path="497" as="498" dim="51" />
-                <Path path="499" as="500" dim="51" />
-                <Path path="501" as="502" dim="51" />
-                <Path path="503" as="504" dim="51" />
-              </Paths>
-            </Formula>
-            <Formula id="CompartmentsVolume_4Comp.VOLUME_pls_SinLin" name="VOLUME_pls_SinLin" dim="Volume" formula="f_vas*(1-HCT)*(V-V_Mucosa)">
-              <Paths>
-                <Path path="167" as="168" />
-                <Path path="169" as="170" dim="51" />
-                <Path path="505" as="506" dim="51" />
-                <Path path="36" as="37" />
-              </Paths>
-            </Formula>
-            <Formula id="CompartmentsVolume_4Comp.VOLUME_bc_SinLin" name="VOLUME_bc_SinLin" dim="Volume" formula="f_vas*HCT*(V-V_Mucosa)">
-              <Paths>
-                <Path path="167" as="168" />
-                <Path path="169" as="170" dim="51" />
-                <Path path="505" as="506" dim="51" />
-                <Path path="36" as="37" />
-              </Paths>
-            </Formula>
-            <Formula id="CompartmentsVolume_4Comp.VOLUME_int_SinLin" name="VOLUME_int_SinLin" dim="Volume" formula="f_int*(V-V_Mucosa)">
-              <Paths>
-                <Path path="192" as="189" />
-                <Path path="169" as="170" dim="51" />
-                <Path path="505" as="506" dim="51" />
-              </Paths>
-            </Formula>
-            <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_sin" name="PARAM_K_Water_INT_sin" dim="Dimensionless" formula="K_water_int">
-              <Paths>
-                <Path path="507" as="196" />
-              </Paths>
-            </Formula>
-            <Formula id="CompoundCommon.PARAM_ProteinContainerVolume_Organ_SinLin" name="PARAM_ProteinContainerVolume_Organ_SinLin" dim="Volume" formula="Volume-V_Mucosa">
-              <Paths>
-                <Path path="169" as="51" dim="51" />
-                <Path path="505" as="506" dim="51" />
-              </Paths>
-            </Formula>
-            <Formula id="CompartmentsVolume_4Comp.VOLUME_cell_SinLin" name="VOLUME_cell_SinLin" dim="Volume" formula="f_cell*(V-V_Mucosa)">
-              <Paths>
-                <Path path="197" as="198" />
-                <Path path="169" as="170" dim="51" />
-                <Path path="505" as="506" dim="51" />
-              </Paths>
-            </Formula>
-            <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_sin" name="PARAM_K_Water_CELL_sin" dim="Dimensionless" formula="K_water_cell">
-              <Paths>
-                <Path path="508" as="200" />
-              </Paths>
-            </Formula>
-            <Formula id="MucosaVolume.VOLUME_MucosaDuodenum" name="VOLUME_MucosaDuodenum" dim="Volume" formula="V_GutWall*fractionMucosa">
-              <Paths>
-                <Path path="509" as="510" />
-                <Path path="511" as="512" dim="51" />
-              </Paths>
-            </Formula>
-            <Formula id="VascularEndoVolume.VOLUME_VascularEndo_duo" name="VOLUME_VascularEndo_duo" dim="Volume" formula="SA_pls_int*d_endo">
-              <Paths>
-                <Path path="183" as="184" dim="161" />
-                <Path path="513" as="186" dim="187" />
-              </Paths>
-            </Formula>
-            <Formula id="Individual_PKSim.PARAM_Q_lymph_mucosa" name="PARAM_Q_lymph_mucosa" dim="Flow" formula="Q_lymph_intestine * V_seg / V_intestine">
-              <Paths>
-                <Path path="514" as="515" dim="220" />
-                <Path path="516" as="517" dim="51" />
-                <Path path="166" as="518" dim="51" />
-              </Paths>
-            </Formula>
-            <Formula id="Individual_PKSim.PARAM_J_iso_Mucosa" name="PARAM_J_iso_Mucosa" dim="Flow" formula="J_iso_intestine * V_seg / V_intestine">
-              <Paths>
-                <Path path="519" as="520" dim="220" />
-                <Path path="516" as="517" dim="51" />
-                <Path path="166" as="518" dim="51" />
-              </Paths>
-            </Formula>
-            <Formula id="Individual_PKSim.PARAM_Q_mucosa" name="PARAM_Q_mucosa" dim="Flow" formula="Q * fractQ * regionalFractQ">
-              <Paths>
-                <Path path="521" as="522" dim="220" />
-                <Path path="523" as="524" />
-                <Path path="525" as="526" />
-              </Paths>
-            </Formula>
-            <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_duo" name="PARAM_K_Water_INT_duo" dim="Dimensionless" formula="K_water_int">
-              <Paths>
-                <Path path="527" as="196" />
-              </Paths>
-            </Formula>
-            <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_duo" name="PARAM_K_Water_CELL_duo" dim="Dimensionless" formula="K_water_cell">
-              <Paths>
-                <Path path="528" as="200" />
-              </Paths>
-            </Formula>
-            <Formula id="MucosaVolume.VOLUME_MucosaUpperJejunum" name="VOLUME_MucosaUpperJejunum" dim="Volume" formula="V_GutWall*fractionMucosa">
-              <Paths>
-                <Path path="509" as="510" />
-                <Path path="529" as="512" dim="51" />
-              </Paths>
-            </Formula>
-            <Formula id="VascularEndoVolume.VOLUME_VascularEndo_uje" name="VOLUME_VascularEndo_uje" dim="Volume" formula="SA_pls_int*d_endo">
-              <Paths>
-                <Path path="183" as="184" dim="161" />
-                <Path path="530" as="186" dim="187" />
-              </Paths>
-            </Formula>
-            <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_uje" name="PARAM_K_Water_INT_uje" dim="Dimensionless" formula="K_water_int">
-              <Paths>
-                <Path path="531" as="196" />
-              </Paths>
-            </Formula>
-            <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_uje" name="PARAM_K_Water_CELL_uje" dim="Dimensionless" formula="K_water_cell">
-              <Paths>
-                <Path path="532" as="200" />
-              </Paths>
-            </Formula>
-            <Formula id="MucosaVolume.VOLUME_MucosaLowerJejunum" name="VOLUME_MucosaLowerJejunum" dim="Volume" formula="V_GutWall*fractionMucosa">
-              <Paths>
-                <Path path="509" as="510" />
-                <Path path="533" as="512" dim="51" />
-              </Paths>
-            </Formula>
-            <Formula id="VascularEndoVolume.VOLUME_VascularEndo_lje" name="VOLUME_VascularEndo_lje" dim="Volume" formula="SA_pls_int*d_endo">
-              <Paths>
-                <Path path="183" as="184" dim="161" />
-                <Path path="534" as="186" dim="187" />
-              </Paths>
-            </Formula>
-            <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_lje" name="PARAM_K_Water_INT_lje" dim="Dimensionless" formula="K_water_int">
-              <Paths>
-                <Path path="535" as="196" />
-              </Paths>
-            </Formula>
-            <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_lje" name="PARAM_K_Water_CELL_lje" dim="Dimensionless" formula="K_water_cell">
-              <Paths>
-                <Path path="536" as="200" />
-              </Paths>
-            </Formula>
-            <Formula id="MucosaVolume.VOLUME_MucosaUpperIleum" name="VOLUME_MucosaUpperIleum" dim="Volume" formula="V_GutWall*fractionMucosa">
-              <Paths>
-                <Path path="509" as="510" />
-                <Path path="537" as="512" dim="51" />
-              </Paths>
-            </Formula>
-            <Formula id="VascularEndoVolume.VOLUME_VascularEndo_uil" name="VOLUME_VascularEndo_uil" dim="Volume" formula="SA_pls_int*d_endo">
-              <Paths>
-                <Path path="183" as="184" dim="161" />
-                <Path path="538" as="186" dim="187" />
-              </Paths>
-            </Formula>
-            <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_uil" name="PARAM_K_Water_INT_uil" dim="Dimensionless" formula="K_water_int">
-              <Paths>
-                <Path path="539" as="196" />
-              </Paths>
-            </Formula>
-            <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_uil" name="PARAM_K_Water_CELL_uil" dim="Dimensionless" formula="K_water_cell">
-              <Paths>
-                <Path path="540" as="200" />
-              </Paths>
-            </Formula>
-            <Formula id="MucosaVolume.VOLUME_MucosaLowerIleum" name="VOLUME_MucosaLowerIleum" dim="Volume" formula="V_GutWall*fractionMucosa">
-              <Paths>
-                <Path path="509" as="510" />
-                <Path path="541" as="512" dim="51" />
-              </Paths>
-            </Formula>
-            <Formula id="VascularEndoVolume.VOLUME_VascularEndo_lil" name="VOLUME_VascularEndo_lil" dim="Volume" formula="SA_pls_int*d_endo">
-              <Paths>
-                <Path path="183" as="184" dim="161" />
-                <Path path="542" as="186" dim="187" />
-              </Paths>
-            </Formula>
-            <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_lil" name="PARAM_K_Water_INT_lil" dim="Dimensionless" formula="K_water_int">
-              <Paths>
-                <Path path="543" as="196" />
-              </Paths>
-            </Formula>
-            <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_lil" name="PARAM_K_Water_CELL_lil" dim="Dimensionless" formula="K_water_cell">
-              <Paths>
-                <Path path="544" as="200" />
-              </Paths>
-            </Formula>
-            <Formula id="MucosaVolume.VOLUME_LargeIntestineMucosa" name="VOLUME_LargeIntestineMucosa" dim="Volume" formula="V_cae+V_ca+V_ct+V_cd+V_cs+V_rec">
-              <Paths>
-                <Path path="545" as="546" dim="51" />
-                <Path path="547" as="548" dim="51" />
-                <Path path="549" as="550" dim="51" />
-                <Path path="551" as="552" dim="51" />
-                <Path path="553" as="554" dim="51" />
-                <Path path="555" as="556" dim="51" />
-              </Paths>
-            </Formula>
-            <Formula id="Lumen_PKSim.PARAM_LITT_Factor" name="PARAM_LITT_Factor" dim="Dimensionless" formula="P1*LITT+P2">
-              <Paths>
-                <Path path="557" as="558" dim="177" />
-                <Path path="559" as="467" />
-                <Path path="560" as="469" dim="46" />
-              </Paths>
-            </Formula>
-            <Formula id="Individual_PKSim.PARAM_FluidRecirculationRate_lin" name="PARAM_FluidRecirculationRate_lin" dim="Flow" formula="J_iso_incl_Mucosa-J_iso_cae-J_iso_colasc-J_iso_coltrans-J_iso_coldesc-J_iso_colsigm-J_iso_rect">
-              <Paths>
-                <Path path="483" as="484" dim="220" />
-                <Path path="561" as="562" dim="220" />
-                <Path path="563" as="564" dim="220" />
-                <Path path="565" as="566" dim="220" />
-                <Path path="567" as="568" dim="220" />
-                <Path path="569" as="570" dim="220" />
-                <Path path="571" as="572" dim="220" />
-              </Paths>
-            </Formula>
-            <Formula id="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate_(incl._mucosa)_LargeIntestine" name="PARAM_Fluid_recirculation_flow_rate_(incl._mucosa)_LargeIntestine" dim="Flow" formula="0.000000000705*(BW/0.02)^0.75">
-              <Paths>
-                <Path path="162" as="163" dim="118" />
-              </Paths>
-            </Formula>
-            <Formula id="Individual_PKSim.PARAM_Q_Lymph_lin" name="PARAM_Q_Lymph_lin" dim="Flow" formula="Q_lymph_incl_Mucosa-Q_lymph_cae-Q_lymph_colasc-Q_lymph_coltrans-Q_lymph_coldesc-Q_lymph_colsigm-Q_lymph_rect">
-              <Paths>
-                <Path path="470" as="471" dim="220" />
-                <Path path="573" as="574" dim="220" />
-                <Path path="575" as="576" dim="220" />
-                <Path path="577" as="578" dim="220" />
-                <Path path="579" as="580" dim="220" />
-                <Path path="581" as="582" dim="220" />
-                <Path path="583" as="584" dim="220" />
-              </Paths>
-            </Formula>
-            <Formula id="Individual_PKSim.PARAM_Lymph_flow_rate_(incl._mucosa)_LargeIntestine" name="PARAM_Lymph_flow_rate_(incl._mucosa)_LargeIntestine" dim="Flow" formula="0.00000034*BW/0.02">
-              <Paths>
-                <Path path="162" as="163" dim="118" />
-              </Paths>
-            </Formula>
-            <Formula id="VascularEndoVolume.VOLUME_VascularEndo_lin" name="VOLUME_VascularEndo_lin" dim="Volume" formula="SA_pls_int*d_endo">
-              <Paths>
-                <Path path="183" as="184" dim="161" />
-                <Path path="585" as="186" dim="187" />
-              </Paths>
-            </Formula>
-            <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_lin" name="PARAM_K_Water_INT_lin" dim="Dimensionless" formula="K_water_int">
-              <Paths>
-                <Path path="586" as="196" />
-              </Paths>
-            </Formula>
-            <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_lin" name="PARAM_K_Water_CELL_lin" dim="Dimensionless" formula="K_water_cell">
-              <Paths>
-                <Path path="587" as="200" />
-              </Paths>
-            </Formula>
-            <Formula id="MucosaVolume.VOLUME_MucosaCaecum" name="VOLUME_MucosaCaecum" dim="Volume" formula="V_GutWall*fractionMucosa">
-              <Paths>
-                <Path path="509" as="510" />
-                <Path path="588" as="512" dim="51" />
-              </Paths>
-            </Formula>
-            <Formula id="VascularEndoVolume.VOLUME_VascularEndo_cae" name="VOLUME_VascularEndo_cae" dim="Volume" formula="SA_pls_int*d_endo">
-              <Paths>
-                <Path path="183" as="184" dim="161" />
-                <Path path="589" as="186" dim="187" />
-              </Paths>
-            </Formula>
-            <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_cae" name="PARAM_K_Water_INT_cae" dim="Dimensionless" formula="K_water_int">
-              <Paths>
-                <Path path="590" as="196" />
-              </Paths>
-            </Formula>
-            <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_cae" name="PARAM_K_Water_CELL_cae" dim="Dimensionless" formula="K_water_cell">
-              <Paths>
-                <Path path="591" as="200" />
-              </Paths>
-            </Formula>
-            <Formula id="MucosaVolume.VOLUME_MucosaColonAscendens" name="VOLUME_MucosaColonAscendens" dim="Volume" formula="V_GutWall*fractionMucosa">
-              <Paths>
-                <Path path="509" as="510" />
-                <Path path="592" as="512" dim="51" />
-              </Paths>
-            </Formula>
-            <Formula id="VascularEndoVolume.VOLUME_VascularEndo_colasc" name="VOLUME_VascularEndo_colasc" dim="Volume" formula="SA_pls_int*d_endo">
-              <Paths>
-                <Path path="183" as="184" dim="161" />
-                <Path path="593" as="186" dim="187" />
-              </Paths>
-            </Formula>
-            <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_colasc" name="PARAM_K_Water_INT_colasc" dim="Dimensionless" formula="K_water_int">
-              <Paths>
-                <Path path="594" as="196" />
-              </Paths>
-            </Formula>
-            <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_colasc" name="PARAM_K_Water_CELL_colasc" dim="Dimensionless" formula="K_water_cell">
-              <Paths>
-                <Path path="595" as="200" />
-              </Paths>
-            </Formula>
-            <Formula id="MucosaVolume.VOLUME_MucosaColonTransversum" name="VOLUME_MucosaColonTransversum" dim="Volume" formula="V_GutWall*fractionMucosa">
-              <Paths>
-                <Path path="509" as="510" />
-                <Path path="596" as="512" dim="51" />
-              </Paths>
-            </Formula>
-            <Formula id="VascularEndoVolume.VOLUME_VascularEndo_coltrans" name="VOLUME_VascularEndo_coltrans" dim="Volume" formula="SA_pls_int*d_endo">
-              <Paths>
-                <Path path="183" as="184" dim="161" />
-                <Path path="597" as="186" dim="187" />
-              </Paths>
-            </Formula>
-            <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_coltrans" name="PARAM_K_Water_INT_coltrans" dim="Dimensionless" formula="K_water_int">
-              <Paths>
-                <Path path="598" as="196" />
-              </Paths>
-            </Formula>
-            <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_coltrans" name="PARAM_K_Water_CELL_coltrans" dim="Dimensionless" formula="K_water_cell">
-              <Paths>
-                <Path path="599" as="200" />
-              </Paths>
-            </Formula>
-            <Formula id="MucosaVolume.VOLUME_MucosaColonDescendens" name="VOLUME_MucosaColonDescendens" dim="Volume" formula="V_GutWall*fractionMucosa">
-              <Paths>
-                <Path path="509" as="510" />
-                <Path path="600" as="512" dim="51" />
-              </Paths>
-            </Formula>
-            <Formula id="VascularEndoVolume.VOLUME_VascularEndo_coldesc" name="VOLUME_VascularEndo_coldesc" dim="Volume" formula="SA_pls_int*d_endo">
-              <Paths>
-                <Path path="183" as="184" dim="161" />
-                <Path path="601" as="186" dim="187" />
-              </Paths>
-            </Formula>
-            <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_coldesc" name="PARAM_K_Water_INT_coldesc" dim="Dimensionless" formula="K_water_int">
-              <Paths>
-                <Path path="602" as="196" />
-              </Paths>
-            </Formula>
-            <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_coldesc" name="PARAM_K_Water_CELL_coldesc" dim="Dimensionless" formula="K_water_cell">
-              <Paths>
-                <Path path="603" as="200" />
-              </Paths>
-            </Formula>
-            <Formula id="MucosaVolume.VOLUME_MucosaColonSigmoid" name="VOLUME_MucosaColonSigmoid" dim="Volume" formula="V_GutWall*fractionMucosa">
-              <Paths>
-                <Path path="509" as="510" />
-                <Path path="604" as="512" dim="51" />
-              </Paths>
-            </Formula>
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-            <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_colsigm" name="PARAM_K_Water_INT_colsigm" dim="Dimensionless" formula="K_water_int">
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-            </Formula>
-            <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_colsigm" name="PARAM_K_Water_CELL_colsigm" dim="Dimensionless" formula="K_water_cell">
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-            </Formula>
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-            </Formula>
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-            </Formula>
-            <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_rect" name="PARAM_K_Water_INT_rect" dim="Dimensionless" formula="K_water_int">
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-            </Formula>
-            <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_rect" name="PARAM_K_Water_CELL_rect" dim="Dimensionless" formula="K_water_cell">
-              <Paths>
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-            </Formula>
-            <Formula id="VascularEndoVolume.VOLUME_VascularEndo_liv" name="VOLUME_VascularEndo_liv" dim="Volume" formula="SA_pls_int*d_endo">
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-            </Formula>
-            <Formula id="Individual_PKSim.PARAM_Lymph_flow_rate_Liver" name="PARAM_Lymph_flow_rate_Liver" dim="Flow" formula="0.0000091*BW/0.02">
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-            </Formula>
-            <Formula id="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate_Liver" name="PARAM_Fluid_recirculation_flow_rate_Liver" dim="Flow" formula="0.00000169*(BW/0.02)^0.75">
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-            </Formula>
-            <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_liv" name="PARAM_K_Water_INT_liv" dim="Dimensionless" formula="K_water_int">
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-            <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_liv" name="PARAM_K_Water_CELL_liv" dim="Dimensionless" formula="K_water_cell">
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-            </Formula>
-            <Formula id="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate_Lung" name="PARAM_Fluid_recirculation_flow_rate_Lung" dim="Flow" formula="0.000000000301*(BW/0.02)^0.75">
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-            </Formula>
-            <Formula id="VascularEndoVolume.VOLUME_VascularEndo_lng" name="VOLUME_VascularEndo_lng" dim="Volume" formula="SA_pls_int*d_endo">
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-            </Formula>
-            <Formula id="Individual_PKSim.PARAM_Lymph_flow_rate_Lung" name="PARAM_Lymph_flow_rate_Lung" dim="Flow" formula="0.000005*BW/0.02">
-              <Paths>
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-            </Formula>
-            <Formula id="Individual_PKSim.PARAM_Q_lng" name="PARAM_Q_lng" dim="Flow" formula="Q_sto + Q_sin + Q_lin + Q_pan + Q_spl + Q_liv + Q_mus + Q_fat + Q_skn + Q_kid + Q_brn + Q_hrt + Q_bon + Q_tes">
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-            </Formula>
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-            <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_lng" name="PARAM_K_Water_CELL_lng" dim="Dimensionless" formula="K_water_cell">
-              <Paths>
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-              </Paths>
-            </Formula>
-            <Formula id="Individual_PKSim.PARAM_Lymph_flow_rate_Muscle" name="PARAM_Lymph_flow_rate_Muscle" dim="Flow" formula="0.00000055*BW/0.02">
-              <Paths>
-                <Path path="162" as="163" dim="118" />
-              </Paths>
-            </Formula>
-            <Formula id="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate_Muscle" name="PARAM_Fluid_recirculation_flow_rate_Muscle" dim="Flow" formula="0.000000111*(BW/0.02)^0.75">
-              <Paths>
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-            </Formula>
-            <Formula id="VascularEndoVolume.VOLUME_VascularEndo_mus" name="VOLUME_VascularEndo_mus" dim="Volume" formula="SA_pls_int*d_endo">
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-              </Paths>
-            </Formula>
-            <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_mus" name="PARAM_K_Water_INT_mus" dim="Dimensionless" formula="K_water_int">
-              <Paths>
-                <Path path="647" as="196" />
-              </Paths>
-            </Formula>
-            <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_mus" name="PARAM_K_Water_CELL_mus" dim="Dimensionless" formula="K_water_cell">
-              <Paths>
-                <Path path="648" as="200" />
-              </Paths>
-            </Formula>
-            <Formula id="VascularEndoVolume.VOLUME_VascularEndo_pan" name="VOLUME_VascularEndo_pan" dim="Volume" formula="SA_pls_int*d_endo">
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-                <Path path="183" as="184" dim="161" />
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-            </Formula>
-            <Formula id="Individual_PKSim.PARAM_Lymph_flow_rate_Pancreas" name="PARAM_Lymph_flow_rate_Pancreas" dim="Flow" formula="0.00000065*BW/0.02">
-              <Paths>
-                <Path path="162" as="163" dim="118" />
-              </Paths>
-            </Formula>
-            <Formula id="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate_Pancreas" name="PARAM_Fluid_recirculation_flow_rate_Pancreas" dim="Flow" formula="0.0000000872*(BW/0.02)^0.75">
-              <Paths>
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-              </Paths>
-            </Formula>
-            <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_pan" name="PARAM_K_Water_INT_pan" dim="Dimensionless" formula="K_water_int">
-              <Paths>
-                <Path path="650" as="196" />
-              </Paths>
-            </Formula>
-            <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_pan" name="PARAM_K_Water_CELL_pan" dim="Dimensionless" formula="K_water_cell">
-              <Paths>
-                <Path path="651" as="200" />
-              </Paths>
-            </Formula>
-            <Formula id="Individual_PKSim.PARAM_Q_Lymph_pve" name="PARAM_Q_Lymph_pve" dim="Flow" formula="Q_Lymph_sto + Q_Lymph_sin_incl_Mucosa + Q_Lymph_lin_incl_Mucosa + Q_Lymph_pan + Q_Lymph_spl">
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-            </Formula>
-            <Formula id="Individual_PKSim.PARAM_Q_pve" name="PARAM_Q_pve" dim="Flow" formula="Q_sto + Q_sin + Q_lin + Q_pan + Q_spl">
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-            </Formula>
-            <Formula id="VascularEndoVolume.VOLUME_VascularEndo_skn" name="VOLUME_VascularEndo_skn" dim="Volume" formula="SA_pls_int*d_endo">
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-            </Formula>
-            <Formula id="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate_Skin" name="PARAM_Fluid_recirculation_flow_rate_Skin" dim="Flow" formula="0.000000342*(BW/0.02)^0.75">
-              <Paths>
-                <Path path="162" as="163" dim="118" />
-              </Paths>
-            </Formula>
-            <Formula id="Individual_PKSim.PARAM_Lymph_flow_rate_Skin" name="PARAM_Lymph_flow_rate_Skin" dim="Flow" formula="0.00000051*BW/0.02">
-              <Paths>
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-              </Paths>
-            </Formula>
-            <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_skn" name="PARAM_K_Water_INT_skn" dim="Dimensionless" formula="K_water_int">
-              <Paths>
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-              </Paths>
-            </Formula>
-            <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_skn" name="PARAM_K_Water_CELL_skn" dim="Dimensionless" formula="K_water_cell">
-              <Paths>
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-            </Formula>
-            <Formula id="Individual_PKSim.PARAM_Lymph_flow_rate_Spleen" name="PARAM_Lymph_flow_rate_Spleen" dim="Flow" formula="0.000008*BW/0.02">
-              <Paths>
-                <Path path="162" as="163" dim="118" />
-              </Paths>
-            </Formula>
-            <Formula id="VascularEndoVolume.VOLUME_VascularEndo_spl" name="VOLUME_VascularEndo_spl" dim="Volume" formula="SA_pls_int*d_endo">
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-            </Formula>
-            <Formula id="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate_Spleen" name="PARAM_Fluid_recirculation_flow_rate_Spleen" dim="Flow" formula="0.0000000000961*(BW/0.02)^0.75">
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-            </Formula>
-            <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_spl" name="PARAM_K_Water_INT_spl" dim="Dimensionless" formula="K_water_int">
-              <Paths>
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-              </Paths>
-            </Formula>
-            <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_spl" name="PARAM_K_Water_CELL_spl" dim="Dimensionless" formula="K_water_cell">
-              <Paths>
-                <Path path="667" as="200" />
-              </Paths>
-            </Formula>
-            <Formula id="Individual_PKSim.VOLUME_Saliva_Organ" name="VOLUME_Saliva_Organ" dim="Volume" formula="0.006 * BW / 73">
-              <Paths>
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-              </Paths>
-            </Formula>
-            <Formula id="CompartmentsVolume_4Comp.VOLUME_slv_slv" name="VOLUME_slv_slv" dim="Volume" formula="V_slv">
-              <Paths>
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-              </Paths>
-            </Formula>
-            <Formula id="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls_Blood_Organ" name="PARAM_SA_rbc_pls_Blood_Organ" dim="Area" formula="HCT * A_to_V_bc * 0.6 * V">
-              <Paths>
-                <Path path="670" as="170" dim="51" />
-                <Path path="36" as="37" />
-                <Path path="671" as="672" dim="343" />
-              </Paths>
-            </Formula>
-            <Formula id="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" name="PARAM_SA_pls_int" dim="Area" formula="k * f_vas_org * V_org">
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-                <Path path="675" as="316" dim="343" />
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-            </Formula>
-            <BlackBoxFormula id="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" name="INTERSTITIAL PARTITION COEFFICIENT FORMULA" dim="Dimensionless" />
-            <Formula id="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" name="PARAM_SA_rbc_pls" dim="Area" formula="HCT * A_to_V_bc * 0.6 * V * f_vas">
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-                <Path path="36" as="37" />
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-            </Formula>
-            <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_bon" name="PARAM_SA_int_cell_bon" dim="Area" formula="(V_bon * 1000 / 28.2)^0.75 * 10 * 1E2">
-              <Paths>
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-              </Paths>
-            </Formula>
-            <Formula id="DistributionCommon_PKSim.PARAM_K_wat_cell" name="PARAM_K_wat_cell" dim="Dimensionless" formula="fu/K_cell_pls">
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-                <Path path="29" as="30" dim="20" />
-              </Paths>
-            </Formula>
-            <Formula id="DiffusionCommon_PKSim.PARAM_P_int_cell" name="PARAM_P_int_cell" dim="Velocity" formula="P * P_int_cell_factor">
-              <Paths>
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-                <Path path="9" as="10" dim="2" />
-              </Paths>
-            </Formula>
-            <Formula id="DiffusionCommon_PKSim.PARAM_P_cell_int" name="PARAM_P_cell_int" dim="Velocity" formula="P * P_cell_int_factor">
-              <Paths>
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-                <Path path="9" as="10" dim="2" />
-              </Paths>
-            </Formula>
-            <Formula id="DiffusionCommon_PKSim.PARAM_PA_int_cell" name="PARAM_PA_int_cell" dim="Flow" formula="P_int_cell * SA">
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-                <Path path="684" as="685" dim="187" />
-              </Paths>
-            </Formula>
-            <Formula id="DiffusionCommon_PKSim.PARAM_PA_cell_int" name="PARAM_PA_cell_int" dim="Flow" formula="P_cell_int * SA">
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-              </Paths>
-            </Formula>
-            <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_brn" name="PARAM_SA_int_cell_brn" dim="Area" formula="(V_brn  * 1000 / 1.671)^0.75 * 0.0006 * 1E2">
-              <Paths>
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-            </Formula>
-            <Formula id="DiffusionPlasma_PKSim.PARAM_P_endothelial_Brain" name="PARAM_P_endothelial_Brain" dim="Velocity" formula="P/2">
-              <Paths>
-                <Path path="9" as="10" dim="2" />
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-            </Formula>
-            <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_fat" name="PARAM_SA_int_cell_fat" dim="Area" formula="(V_fat * 1000 / 14.2)^0.75 * 5 * 1E2">
-              <Paths>
-                <Path path="670" as="63" dim="51" />
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-            </Formula>
-            <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_tes" name="PARAM_SA_int_cell_tes" dim="Area" formula="(V_tes * 1000 / 2.5)^0.75 * 2 * 1E2">
-              <Paths>
-                <Path path="670" as="67" dim="51" />
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-            </Formula>
-            <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_hrt" name="PARAM_SA_int_cell_hrt" dim="Area" formula="(V_hrt * 1000 / 1.2)^0.75 * 7.54 * 1E2">
-              <Paths>
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-            </Formula>
-            <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_kid" name="PARAM_SA_int_cell_kid" dim="Area" formula="(V_kid * 1000 / 7)^0.75 * 1000 * 1E2">
-              <Paths>
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-            </Formula>
-            <Formula id="DistributionCommon_PKSim.PARAM_K_water_cell_Kidney" name="PARAM_K_water_cell_Kidney" dim="Dimensionless" formula="K_water_cell">
-              <Paths>
-                <Path path="228" as="200" />
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-            </Formula>
-            <Formula id="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPvePlasma" name="PARAM_MassTransferMucosaToPvePlasma" dim="Amount per time" formula="Q*(1-HCT)*C_pls">
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-                <Path path="691" as="522" dim="220" />
-                <Path path="36" as="37" />
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-            </Formula>
-            <SumFormula id="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" name="PARAM_SumOfActiveProcessRates" dim="Amount per time" variable="P" formulaString="P_#i">
-              <Criteria>
-                <DescriptorConditions>
-                  <MatchTagCondition tag="Active" />
-                  <MatchTagCondition tag="MOLECULE" />
-                  <MatchTagCondition tag="NEIGHBORHOOD" />
-                  <MatchTagCondition tag="ProcessRate" />
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-              </Criteria>
-            </SumFormula>
-            <SumFormula id="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" name="PARAM_SumOfPassiveProcessRates" dim="Amount per time" variable="P" formulaString="P_#i">
-              <Criteria>
-                <DescriptorConditions>
-                  <MatchTagCondition tag="MOLECULE" />
-                  <MatchTagCondition tag="NEIGHBORHOOD" />
-                  <MatchTagCondition tag="Passive" />
-                  <MatchTagCondition tag="ProcessRate" />
-                </DescriptorConditions>
-              </Criteria>
-            </SumFormula>
-            <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K6" name="PARAM_pKa_pH_WS_lum_K6" dim="Dimensionless" formula="(1-F1)*F2*(1-F3)">
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-                <Path path="264" as="265" />
-                <Path path="266" as="267" />
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-            </Formula>
-            <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K5" name="PARAM_pKa_pH_WS_mucosacell_K5" dim="Dimensionless" formula="(1-F1)*(1-F2)*F3">
-              <Paths>
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-                <Path path="693" as="265" />
-                <Path path="694" as="267" />
-              </Paths>
-            </Formula>
-            <Formula id="Lumen_PKSim.PARAM_DrugAbsorption_trans" name="PARAM_DrugAbsorption_trans" dim="Amount per time" formula="OralApplicationsEnabled ? P_int_trans*Ageom*AeffFactor*(P_int_trans_lum_cell_factor*min(Solubility/ MW ;DrugLiquid/(Liquid))-(NOT SinkCondition_trans ? P_int_trans_cell_lum_factor*fu/K_cell_pls*DrugMucosa : 0)) : 0">
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-                <Path path="714" as="257" />
-                <Path path="715" as="716" />
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-            </Formula>
-            <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_cell_lum_factor" name="PARAM_P_int_trans_cell_lum_factor" dim="Dimensionless" formula="UsePenaltyFactor ? K1+ (K2 +K3 +K4)* base ^ 1 + K5* base ^ max(CT0+CT1;-CT0-CT1) +K6* base ^ max(CT0+CT2;-CT0-CT2) +K7* base ^ max(CT2+CT1;-CT2-CT1) +K8* base ^ max(CT0+CT1+CT2;-CT0-CT1-CT2) : 1">
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-              </Paths>
-            </Formula>
-            <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_lum_cell_factor" name="PARAM_P_int_trans_lum_cell_factor" dim="Dimensionless" formula="UsePenaltyFactor ? K1+ (K2 +K3 +K4)* base ^ 1 + K5* base ^ max(CT0+CT1;-CT0-CT1) +K6* base ^ max(CT0+CT2;-CT0-CT2) +K7* base ^ max(CT2+CT1;-CT2-CT1) +K8* base ^ max(CT0+CT1+CT2;-CT0-CT1-CT2) : 1">
-              <Paths>
-                <Path path="285" as="286" />
-                <Path path="287" as="288" />
-                <Path path="289" as="290" />
-                <Path path="291" as="292" />
-                <Path path="293" as="294" />
-                <Path path="295" as="296" />
-                <Path path="297" as="298" />
-                <Path path="299" as="300" />
-                <Path path="725" as="302" />
-                <Path path="280" as="281" />
-                <Path path="276" as="277" />
-                <Path path="268" as="269" />
-                <Path path="726" as="727" />
-              </Paths>
-            </Formula>
-            <Formula id="Lumen_PKSim.PARAM_K_cell_pls_UpperJejunum" name="PARAM_K_cell_pls_UpperJejunum" dim="Dimensionless" formula="K_cell_pls">
-              <Paths>
-                <Path path="728" as="677" />
-              </Paths>
-            </Formula>
-            <Formula id="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_UpperJejunum" name="PARAM_K_wat_cell_Lumen_UpperJejunum" dim="Dimensionless" formula="K_water_cell">
-              <Paths>
-                <Path path="532" as="200" />
-              </Paths>
-            </Formula>
-            <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F1" name="PARAM_pKa_pH_WS_mucosacell_F1" dim="Dimensionless" formula="CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1">
-              <Paths>
-                <Path path="280" as="281" />
-                <Path path="270" as="271" />
-                <Path path="282" as="283" />
-                <Path path="729" as="275" />
-              </Paths>
-            </Formula>
-            <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F2" name="PARAM_pKa_pH_WS_mucosacell_F2" dim="Dimensionless" formula="CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1">
-              <Paths>
-                <Path path="276" as="277" />
-                <Path path="270" as="271" />
-                <Path path="278" as="279" />
-                <Path path="729" as="275" />
-              </Paths>
-            </Formula>
-            <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F3" name="PARAM_pKa_pH_WS_mucosacell_F3" dim="Dimensionless" formula="CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1">
-              <Paths>
-                <Path path="268" as="269" />
-                <Path path="270" as="271" />
-                <Path path="272" as="273" />
-                <Path path="729" as="275" />
-              </Paths>
-            </Formula>
-            <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K1" name="PARAM_pKa_pH_WS_mucosacell_K1" dim="Dimensionless" formula="F1*F2*F3">
-              <Paths>
-                <Path path="692" as="263" />
-                <Path path="693" as="265" />
-                <Path path="694" as="267" />
-              </Paths>
-            </Formula>
-            <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K2" name="PARAM_pKa_pH_WS_mucosacell_K2" dim="Dimensionless" formula="(1-F1)*F2*F3">
-              <Paths>
-                <Path path="692" as="263" />
-                <Path path="693" as="265" />
-                <Path path="694" as="267" />
-              </Paths>
-            </Formula>
-            <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K8" name="PARAM_pKa_pH_WS_lum_K8" dim="Dimensionless" formula="(1-F1)*(1-F2)*(1-F3)">
-              <Paths>
-                <Path path="262" as="263" />
-                <Path path="264" as="265" />
-                <Path path="266" as="267" />
-              </Paths>
-            </Formula>
-            <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K4" name="PARAM_pKa_pH_WS_mucosacell_K4" dim="Dimensionless" formula="F1*F2*(1-F3)">
-              <Paths>
-                <Path path="692" as="263" />
-                <Path path="693" as="265" />
-                <Path path="694" as="267" />
-              </Paths>
-            </Formula>
-            <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K7" name="PARAM_pKa_pH_WS_lum_K7" dim="Dimensionless" formula="F1*(1-F2)*(1-F3)">
-              <Paths>
-                <Path path="262" as="263" />
-                <Path path="264" as="265" />
-                <Path path="266" as="267" />
-              </Paths>
-            </Formula>
-            <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K6" name="PARAM_pKa_pH_WS_mucosacell_K6" dim="Dimensionless" formula="(1-F1)*F2*(1-F3)">
-              <Paths>
-                <Path path="692" as="263" />
-                <Path path="693" as="265" />
-                <Path path="694" as="267" />
-              </Paths>
-            </Formula>
-            <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K7" name="PARAM_pKa_pH_WS_mucosacell_K7" dim="Dimensionless" formula="F1*(1-F2)*(1-F3)">
-              <Paths>
-                <Path path="692" as="263" />
-                <Path path="693" as="265" />
-                <Path path="694" as="267" />
-              </Paths>
-            </Formula>
-            <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K8" name="PARAM_pKa_pH_WS_mucosacell_K8" dim="Dimensionless" formula="(1-F1)*(1-F2)*(1-F3)">
-              <Paths>
-                <Path path="692" as="263" />
-                <Path path="693" as="265" />
-                <Path path="694" as="267" />
-              </Paths>
-            </Formula>
-            <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F1" name="PARAM_pKa_pH_WS_lum_F1" dim="Dimensionless" formula="CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1">
-              <Paths>
-                <Path path="730" as="275" />
-                <Path path="280" as="281" />
-                <Path path="270" as="271" />
-                <Path path="282" as="283" />
-              </Paths>
-            </Formula>
-            <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F2" name="PARAM_pKa_pH_WS_lum_F2" dim="Dimensionless" formula="CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1">
-              <Paths>
-                <Path path="730" as="275" />
-                <Path path="276" as="277" />
-                <Path path="270" as="271" />
-                <Path path="278" as="279" />
-              </Paths>
-            </Formula>
-            <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F3" name="PARAM_pKa_pH_WS_lum_F3" dim="Dimensionless" formula="CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1">
-              <Paths>
-                <Path path="730" as="275" />
-                <Path path="268" as="269" />
-                <Path path="270" as="271" />
-                <Path path="272" as="273" />
-              </Paths>
-            </Formula>
-            <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K1" name="PARAM_pKa_pH_WS_lum_K1" dim="Dimensionless" formula="F1*F2*F3">
-              <Paths>
-                <Path path="262" as="263" />
-                <Path path="264" as="265" />
-                <Path path="266" as="267" />
-              </Paths>
-            </Formula>
-            <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K2" name="PARAM_pKa_pH_WS_lum_K2" dim="Dimensionless" formula="(1-F1)*F2*F3">
-              <Paths>
-                <Path path="262" as="263" />
-                <Path path="264" as="265" />
-                <Path path="266" as="267" />
-              </Paths>
-            </Formula>
-            <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K3" name="PARAM_pKa_pH_WS_lum_K3" dim="Dimensionless" formula="F1*(1-F2)*F3">
-              <Paths>
-                <Path path="262" as="263" />
-                <Path path="264" as="265" />
-                <Path path="266" as="267" />
-              </Paths>
-            </Formula>
-            <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K4" name="PARAM_pKa_pH_WS_lum_K4" dim="Dimensionless" formula="F1*F2*(1-F3)">
-              <Paths>
-                <Path path="262" as="263" />
-                <Path path="264" as="265" />
-                <Path path="266" as="267" />
-              </Paths>
-            </Formula>
-            <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K5" name="PARAM_pKa_pH_WS_lum_K5" dim="Dimensionless" formula="(1-F1)*(1-F2)*F3">
-              <Paths>
-                <Path path="262" as="263" />
-                <Path path="264" as="265" />
-                <Path path="266" as="267" />
-              </Paths>
-            </Formula>
-            <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K3" name="PARAM_pKa_pH_WS_mucosacell_K3" dim="Dimensionless" formula="F1*(1-F2)*F3">
-              <Paths>
-                <Path path="692" as="263" />
-                <Path path="693" as="265" />
-                <Path path="694" as="267" />
-              </Paths>
-            </Formula>
-            <Formula id="Lumen_PKSim.PARAM_DrugAbsorption_para" name="PARAM_DrugAbsorption_para" dim="Amount per time" formula="OralApplicationsEnabled ? P_int_para*Ageom*AeffFactor*(min(Solubility/ MW ;DrugLiquid/(Liquid))-(NOT SinkCondition_para ? fu*DrugMucosa : 0)) : 0">
-              <Paths>
-                <Path path="695" as="696" />
-                <Path path="697" as="698" dim="187" />
-                <Path path="699" as="247" dim="51" />
-                <Path path="700" as="701" dim="702" />
-                <Path path="703" as="704" dim="690" />
-                <Path path="29" as="30" dim="20" />
-                <Path path="731" as="732" dim="2" />
-                <Path path="706" as="707" dim="708" />
-                <Path path="713" as="306" dim="307" />
-                <Path path="714" as="257" />
-                <Path path="733" as="734" />
-              </Paths>
-            </Formula>
-            <Formula id="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPveBloodCells" name="PARAM_MassTransferMucosaToPveBloodCells" dim="Amount per time" formula="Q*HCT*C_bc">
-              <Paths>
-                <Path path="688" as="735" dim="690" />
-                <Path path="691" as="522" dim="220" />
-                <Path path="36" as="37" />
-              </Paths>
-            </Formula>
-            <Formula id="Lumen_PKSim.PARAM_OralMassAbsorbed" name="PARAM_OralMassAbsorbed" dim="Amount" formula="MAbs_duo + MAbs_uje + MAbs_lje + MAbs_uil + MAbs_lil + MAbs_cae + MAbs_colasc + MAbs_coltrans + MAbs_coldesc + MAbs_colsigm + MAbs_rect">
-              <Paths>
-                <Path path="736" as="737" dim="702" />
-                <Path path="738" as="739" dim="702" />
-                <Path path="740" as="741" dim="702" />
-                <Path path="742" as="743" dim="702" />
-                <Path path="744" as="745" dim="702" />
-                <Path path="746" as="747" dim="702" />
-                <Path path="748" as="749" dim="702" />
-                <Path path="750" as="751" dim="702" />
-                <Path path="752" as="753" dim="702" />
-                <Path path="754" as="755" dim="702" />
-                <Path path="756" as="757" dim="702" />
-              </Paths>
-            </Formula>
-            <Formula id="Lumen_PKSim.PARAM_K_cell_pls_LowerJejunum" name="PARAM_K_cell_pls_LowerJejunum" dim="Dimensionless" formula="K_cell_pls">
-              <Paths>
-                <Path path="758" as="677" />
-              </Paths>
-            </Formula>
-            <Formula id="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_LowerJejunum" name="PARAM_K_wat_cell_Lumen_LowerJejunum" dim="Dimensionless" formula="K_water_cell">
-              <Paths>
-                <Path path="536" as="200" />
-              </Paths>
-            </Formula>
-            <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_sto" name="PARAM_SA_int_cell_sto" dim="Area" formula="(V_sto * 1000 / 1.1)^0.75 * 1000 * 1E2">
-              <Paths>
-                <Path path="670" as="113" dim="51" />
-              </Paths>
-            </Formula>
-            <Formula id="Lumen_PKSim.PARAM_K_cell_pls_UpperIleum" name="PARAM_K_cell_pls_UpperIleum" dim="Dimensionless" formula="K_cell_pls">
-              <Paths>
-                <Path path="759" as="677" />
-              </Paths>
-            </Formula>
-            <Formula id="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_UpperIleum" name="PARAM_K_wat_cell_Lumen_UpperIleum" dim="Dimensionless" formula="K_water_cell">
-              <Paths>
-                <Path path="540" as="200" />
-              </Paths>
-            </Formula>
-            <Formula id="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaBloodCells" name="PARAM_MassTransferIntestineToMucosaBloodCells" dim="Amount per time" formula="Q*HCT*C_bc">
-              <Paths>
-                <Path path="760" as="522" dim="220" />
-                <Path path="688" as="735" dim="690" />
-                <Path path="36" as="37" />
-              </Paths>
-            </Formula>
-            <Formula id="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaPlasma" name="PARAM_MassTransferIntestineToMucosaPlasma" dim="Amount per time" formula="Q*(1-HCT)*C_pls">
-              <Paths>
-                <Path path="760" as="522" dim="220" />
-                <Path path="688" as="689" dim="690" />
-                <Path path="36" as="37" />
-              </Paths>
-            </Formula>
-            <Formula id="Lumen_PKSim.PARAM_K_cell_pls_LowerIleum" name="PARAM_K_cell_pls_LowerIleum" dim="Dimensionless" formula="K_cell_pls">
-              <Paths>
-                <Path path="761" as="677" />
-              </Paths>
-            </Formula>
-            <Formula id="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_LowerIleum" name="PARAM_K_wat_cell_Lumen_LowerIleum" dim="Dimensionless" formula="K_water_cell">
-              <Paths>
-                <Path path="544" as="200" />
-              </Paths>
-            </Formula>
-            <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_sin" name="PARAM_SA_int_cell_sin" dim="Area" formula="((V_sin-V_Mucosa) * 1000 / 11.1)^0.75 * 1000 * 1E2">
-              <Paths>
-                <Path path="670" as="105" dim="51" />
-                <Path path="762" as="506" dim="51" />
-              </Paths>
-            </Formula>
-            <Formula id="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int_sinlin" name="PARAM_SA_pls_int_sinlin" dim="Area" formula="k * f_vas_org * (V_org-V_Mucosa)">
-              <Paths>
-                <Path path="673" as="674" />
-                <Path path="670" as="191" dim="51" />
-                <Path path="763" as="506" dim="51" />
-                <Path path="675" as="316" dim="343" />
-              </Paths>
-            </Formula>
-            <Formula id="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls_sinlin" name="PARAM_SA_rbc_pls_sinlin" dim="Area" formula="HCT * A_to_V_bc * 0.6 * (V-V_Mucosa) * f_vas">
-              <Paths>
-                <Path path="673" as="168" />
-                <Path path="670" as="170" dim="51" />
-                <Path path="763" as="506" dim="51" />
-                <Path path="36" as="37" />
-                <Path path="671" as="672" dim="343" />
-              </Paths>
-            </Formula>
-            <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_lin" name="PARAM_SA_int_cell_lin" dim="Area" formula="((V_lin-V_Mucosa) * 1000 / 11.1)^0.75 * 1000 * 1E2">
-              <Paths>
-                <Path path="670" as="79" dim="51" />
-                <Path path="764" as="506" dim="51" />
-              </Paths>
-            </Formula>
-            <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_liv" name="PARAM_SA_int_cell_liv" dim="Area" formula="(V_liv * 1000 / 10)^0.75 * 82 * 1E2">
-              <Paths>
-                <Path path="670" as="83" dim="51" />
-              </Paths>
-            </Formula>
-            <Formula id="PlasmaClearance_PKSim.PARAM_min_PA_Q" name="PARAM_min_PA_Q" dim="Flow" formula="Min(PA_liv ;Q_liv + Q_pve)">
-              <Paths>
-                <Path path="765" as="766" dim="220" />
-                <Path path="691" as="631" dim="220" />
-                <Path path="767" as="768" dim="220" />
-              </Paths>
-            </Formula>
-            <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_lng" name="PARAM_SA_int_cell_lng" dim="Area" formula="(V_lng * 1000  / 2.2)^0.75 * 0.096 * 1E2">
-              <Paths>
-                <Path path="670" as="87" dim="51" />
-              </Paths>
-            </Formula>
-            <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mus" name="PARAM_SA_int_cell_mus" dim="Area" formula="(V_mus * 1000 / 110.1)^0.75 * 7.54 * 1E2">
-              <Paths>
-                <Path path="670" as="91" dim="51" />
-              </Paths>
-            </Formula>
-            <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_pan" name="PARAM_SA_int_cell_pan" dim="Area" formula="(V_pan * 1000 / 1.3)^0.75 * 1000 * 1E2">
-              <Paths>
-                <Path path="670" as="95" dim="51" />
-              </Paths>
-            </Formula>
-            <Formula id="Lumen_PKSim.PARAM_K_cell_pls_Rectum" name="PARAM_K_cell_pls_Rectum" dim="Dimensionless" formula="K_cell_pls">
-              <Paths>
-                <Path path="769" as="677" />
-              </Paths>
-            </Formula>
-            <Formula id="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_Rectum" name="PARAM_K_wat_cell_Lumen_Rectum" dim="Dimensionless" formula="K_water_cell">
-              <Paths>
-                <Path path="611" as="200" />
-              </Paths>
-            </Formula>
-            <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_skn" name="PARAM_SA_int_cell_skn" dim="Area" formula="(V_skn * 1000 / 43.4)^0.75 * 0.12 * 1E2">
-              <Paths>
-                <Path path="670" as="101" dim="51" />
-              </Paths>
-            </Formula>
-            <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_spl" name="PARAM_SA_int_cell_spl" dim="Area" formula="(V_spl * 1000 / 1.3)^0.75 * 1000 * 1E2">
-              <Paths>
-                <Path path="670" as="109" dim="51" />
-              </Paths>
-            </Formula>
-            <Formula id="DistributionSaliva_PKSim.PARAM_K_cell_pls_slv" name="PARAM_K_cell_pls_slv" dim="Dimensionless" formula="R * fu">
-              <Paths>
-                <Path path="770" as="771" />
-                <Path path="29" as="30" dim="20" />
-              </Paths>
-            </Formula>
-            <Formula id="DistributionSaliva_PKSim.PARAM_SalivaPlasmaRatio" name="PARAM_SalivaPlasmaRatio" dim="Dimensionless" formula="1">
-              <Paths>
-                <Path path="282" as="283" />
-                <Path path="278" as="279" />
-                <Path path="272" as="273" />
-                <Path path="772" as="773" />
-                <Path path="774" as="775" />
-              </Paths>
-            </Formula>
-            <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mucosa_duo" name="PARAM_SA_int_cell_mucosa_duo" dim="Area" formula="Ageom * AeffFactor / MicrovilliFactor">
-              <Paths>
-                <Path path="776" as="696" />
-                <Path path="777" as="698" dim="187" />
-                <Path path="778" as="779" />
-              </Paths>
-            </Formula>
-            <Formula id="DiffusionCommon_PKSim.PARAM_P_int_cell_Mucosa" name="PARAM_P_int_cell_Mucosa" dim="Velocity" formula="P * P_int_cell_factor * P_int_scalefactor">
-              <Paths>
-                <Path path="678" as="679" />
-                <Path path="780" as="781" />
-                <Path path="9" as="10" dim="2" />
-              </Paths>
-            </Formula>
-            <Formula id="DiffusionCommon_PKSim.PARAM_P_cell_int_Mucosa" name="PARAM_P_cell_int_Mucosa" dim="Velocity" formula="P * P_cell_int_factor * P_int_scalefactor">
-              <Paths>
-                <Path path="680" as="681" />
-                <Path path="780" as="781" />
-                <Path path="9" as="10" dim="2" />
-              </Paths>
-            </Formula>
-            <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mucosa_uje" name="PARAM_SA_int_cell_mucosa_uje" dim="Area" formula="Ageom * AeffFactor / MicrovilliFactor">
-              <Paths>
-                <Path path="782" as="696" />
-                <Path path="783" as="698" dim="187" />
-                <Path path="784" as="779" />
-              </Paths>
-            </Formula>
-            <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mucosa_lje" name="PARAM_SA_int_cell_mucosa_lje" dim="Area" formula="Ageom * AeffFactor / MicrovilliFactor">
-              <Paths>
-                <Path path="785" as="696" />
-                <Path path="786" as="698" dim="187" />
-                <Path path="787" as="779" />
-              </Paths>
-            </Formula>
-            <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mucosa_uil" name="PARAM_SA_int_cell_mucosa_uil" dim="Area" formula="Ageom * AeffFactor / MicrovilliFactor">
-              <Paths>
-                <Path path="788" as="696" />
-                <Path path="789" as="698" dim="187" />
-                <Path path="790" as="779" />
-              </Paths>
-            </Formula>
-            <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mucosa_lil" name="PARAM_SA_int_cell_mucosa_lil" dim="Area" formula="Ageom * AeffFactor / MicrovilliFactor">
-              <Paths>
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-            </DiscreteDistributionFormula>
-            <DiscreteDistributionFormula id="aroJrJCidUC41UJZ0qqpSg" dim="Dimensionless">
-              <Paths>
-                <Path path="818" as="818" />
-              </Paths>
-            </DiscreteDistributionFormula>
-            <DiscreteDistributionFormula id="EZ16uJUmxky-L0cyidKiEg" dim="Dimensionless">
-              <Paths>
-                <Path path="818" as="818" />
-              </Paths>
-            </DiscreteDistributionFormula>
-            <DiscreteDistributionFormula id="Cd3xvocf6UykHAfN8w9DIw" dim="Dimensionless">
-              <Paths>
-                <Path path="818" as="818" />
-              </Paths>
-            </DiscreteDistributionFormula>
-            <DiscreteDistributionFormula id="gvj2SHge5UmWjBbSrA_jLg" dim="Dimensionless">
-              <Paths>
-                <Path path="818" as="818" />
-              </Paths>
-            </DiscreteDistributionFormula>
-            <DiscreteDistributionFormula id="Yl_tpy9xa0q8-WXbAPkjRw" dim="Dimensionless">
-              <Paths>
-                <Path path="818" as="818" />
-              </Paths>
-            </DiscreteDistributionFormula>
-            <DiscreteDistributionFormula id="3axkvavtF0-lwm_8sylxvw" dim="Dimensionless">
-              <Paths>
-                <Path path="818" as="818" />
-              </Paths>
-            </DiscreteDistributionFormula>
-            <NormalDistributionFormula id="iglelZ00bUCAd9xdA0cIZw" dim="Flow per weight organ">
-              <Paths>
-                <Path path="818" as="818" dim="180" />
-                <Path path="819" as="819" dim="180" />
-              </Paths>
-            </NormalDistributionFormula>
-            <NormalDistributionFormula id="6Qpmxy3Cv0iC9SuRwH2Xmg" dim="Volume">
-              <Paths>
-                <Path path="818" as="818" dim="51" />
-                <Path path="819" as="819" dim="51" />
-              </Paths>
-            </NormalDistributionFormula>
-            <NormalDistributionFormula id="dJzmMnfaekiojqSMPy2oDg" dim="Flow per weight organ">
-              <Paths>
-                <Path path="818" as="818" dim="180" />
-                <Path path="819" as="819" dim="180" />
-              </Paths>
-            </NormalDistributionFormula>
-            <NormalDistributionFormula id="GiwjOS90A0u31I0_VFzNkQ" dim="Volume">
-              <Paths>
-                <Path path="818" as="818" dim="51" />
-                <Path path="819" as="819" dim="51" />
-              </Paths>
-            </NormalDistributionFormula>
-            <NormalDistributionFormula id="poMArFaJ506hpaTU85lfrw" dim="Volume">
-              <Paths>
-                <Path path="818" as="818" dim="51" />
-                <Path path="819" as="819" dim="51" />
-              </Paths>
-            </NormalDistributionFormula>
-            <NormalDistributionFormula id="QFn_snxVvUiKxy7CrfEx7g" dim="Flow per weight organ">
-              <Paths>
-                <Path path="818" as="818" dim="180" />
-                <Path path="819" as="819" dim="180" />
-              </Paths>
-            </NormalDistributionFormula>
-            <LogNormalDistributionFormula id="iaDvgrR2PEOQ0wfw8C3SjA" dim="Volume">
-              <Paths>
-                <Path path="818" as="818" dim="51" />
-                <Path path="820" as="820" />
-              </Paths>
-            </LogNormalDistributionFormula>
-            <NormalDistributionFormula id="7inVHxlxU0Wq9iXjUEuc7g" dim="Flow per weight organ">
-              <Paths>
-                <Path path="818" as="818" dim="180" />
-                <Path path="819" as="819" dim="180" />
-              </Paths>
-            </NormalDistributionFormula>
-          </Formulas>
-          <StringMap>
-            <Map s="MOLECULE|Specific intestinal permeability (transcellular)" id="0" />
-            <Map s="P_int_InVitro" id="1" />
-            <Map s="Velocity" id="2" />
-            <Map s="..|Default Intestinal permeability (transcellular)" id="3" />
-            <Map s="P_int_trans_default" id="4" />
-            <Map s="..|Intestinal permeability (transcellular)" id="5" />
-            <Map s="P_int_trans" id="6" />
-            <Map s="MOLECULE|P_pls_bc_factor" id="7" />
-            <Map s="P_pls_rbc_factor" id="8" />
-            <Map s="MOLECULE|Permeability" id="9" />
-            <Map s="P" id="10" />
-            <Map s="MOLECULE|Calculated specific intestinal permeability (transcellular)" id="11" />
-            <Map s="MOLECULE|P_bc_pls_factor" id="12" />
-            <Map s="P_rbc_pls_factor" id="13" />
-            <Map s="..|BP_AGP" id="14" />
-            <Map s="Agp" id="15" />
-            <Map s="..|BP_ALBUMIN" id="16" />
-            <Map s="Albumin" id="17" />
-            <Map s="..|Fraction unbound (plasma, reference value)" id="18" />
-            <Map s="fu_ref" id="19" />
-            <Map s="Fraction" id="20" />
-            <Map s="..|Plasma protein binding partner" id="21" />
-            <Map s="BindingPartner" id="22" />
-            <Map s="Organism|Ontogeny factor (albumin)" id="23" />
-            <Map s="AlbuminOntgenyFactor" id="24" />
-            <Map s="Organism|Ontogeny factor (alpha1-acid glycoprotein)" id="25" />
-            <Map s="AgpOntogenyFactor" id="26" />
-            <Map s="Organism|Plasma protein scale factor" id="27" />
-            <Map s="PlasmaProteinScaleFactor" id="28" />
-            <Map s="MOLECULE|Fraction unbound (plasma)" id="29" />
-            <Map s="fu" id="30" />
-            <Map s="MOLECULE|Lipophilicity" id="31" />
-            <Map s="LogP" id="32" />
-            <Map s="Log Units" id="33" />
-            <Map s="MOLECULE|Partition coefficient (water/protein)" id="34" />
-            <Map s="KProt" id="35" />
-            <Map s="Organism|Hematocrit" id="36" />
-            <Map s="HCT" id="37" />
-            <Map s="Organism|Vf (lipid, blood cells)" id="38" />
-            <Map s="f_lipids_rbc" id="39" />
-            <Map s="Organism|Vf (protein,blood cells)" id="40" />
-            <Map s="f_proteins_rbc" id="41" />
-            <Map s="Organism|Vf (water,blood cells)" id="42" />
-            <Map s="f_water_rbc" id="43" />
-            <Map s="Organism|Rate constant for endosomal uptake (global)" id="44" />
-            <Map s="K_uptake" id="45" />
-            <Map s="Inversed time" id="46" />
-            <Map s="Organism|Rate constant for recycling from endosomal space (global)" id="47" />
-            <Map s="K_rec" id="48" />
-            <Map s="Organism|ArterialBlood|Volume" id="49" />
-            <Map s="V_art" id="50" />
-            <Map s="Volume" id="51" />
-            <Map s="Organism|Bone|Fraction vascular" id="52" />
-            <Map s="f_vas_bon" id="53" />
-            <Map s="Organism|Bone|Volume" id="54" />
-            <Map s="V_bon" id="55" />
-            <Map s="Organism|Brain|Fraction vascular" id="56" />
-            <Map s="f_vas_brn" id="57" />
-            <Map s="Organism|Brain|Volume" id="58" />
-            <Map s="V_brn" id="59" />
-            <Map s="Organism|Fat|Fraction vascular" id="60" />
-            <Map s="f_vas_fat" id="61" />
-            <Map s="Organism|Fat|Volume" id="62" />
-            <Map s="V_fat" id="63" />
-            <Map s="Organism|Gonads|Fraction vascular" id="64" />
-            <Map s="f_vas_tes" id="65" />
-            <Map s="Organism|Gonads|Volume" id="66" />
-            <Map s="V_tes" id="67" />
-            <Map s="Organism|Heart|Fraction vascular" id="68" />
-            <Map s="f_vas_hrt" id="69" />
-            <Map s="Organism|Heart|Volume" id="70" />
-            <Map s="V_hrt" id="71" />
-            <Map s="Organism|Kidney|Fraction vascular" id="72" />
-            <Map s="f_vas_kid" id="73" />
-            <Map s="Organism|Kidney|Volume" id="74" />
-            <Map s="V_kid" id="75" />
-            <Map s="Organism|LargeIntestine|Fraction vascular" id="76" />
-            <Map s="f_vas_lin" id="77" />
-            <Map s="Organism|LargeIntestine|Volume" id="78" />
-            <Map s="V_lin" id="79" />
-            <Map s="Organism|Liver|Fraction vascular" id="80" />
-            <Map s="f_vas_liv" id="81" />
-            <Map s="Organism|Liver|Volume" id="82" />
-            <Map s="V_liv" id="83" />
-            <Map s="Organism|Lung|Fraction vascular" id="84" />
-            <Map s="f_vas_lng" id="85" />
-            <Map s="Organism|Lung|Volume" id="86" />
-            <Map s="V_lng" id="87" />
-            <Map s="Organism|Muscle|Fraction vascular" id="88" />
-            <Map s="f_vas_mus" id="89" />
-            <Map s="Organism|Muscle|Volume" id="90" />
-            <Map s="V_mus" id="91" />
-            <Map s="Organism|Pancreas|Fraction vascular" id="92" />
-            <Map s="f_vas_pan" id="93" />
-            <Map s="Organism|Pancreas|Volume" id="94" />
-            <Map s="V_pan" id="95" />
-            <Map s="Organism|PortalVein|Volume" id="96" />
-            <Map s="V_pve" id="97" />
-            <Map s="Organism|Skin|Fraction vascular" id="98" />
-            <Map s="f_vas_skn" id="99" />
-            <Map s="Organism|Skin|Volume" id="100" />
-            <Map s="V_skn" id="101" />
-            <Map s="Organism|SmallIntestine|Fraction vascular" id="102" />
-            <Map s="f_vas_sin" id="103" />
-            <Map s="Organism|SmallIntestine|Volume" id="104" />
-            <Map s="V_sin" id="105" />
-            <Map s="Organism|Spleen|Fraction vascular" id="106" />
-            <Map s="f_vas_spl" id="107" />
-            <Map s="Organism|Spleen|Volume" id="108" />
-            <Map s="V_spl" id="109" />
-            <Map s="Organism|Stomach|Fraction vascular" id="110" />
-            <Map s="f_vas_sto" id="111" />
-            <Map s="Organism|Stomach|Volume" id="112" />
-            <Map s="V_sto" id="113" />
-            <Map s="Organism|VenousBlood|Volume" id="114" />
-            <Map s="V_ven" id="115" />
-            <Map s="Organism|ArterialBlood|Weight (tissue)" id="116" />
-            <Map s="M_art" id="117" />
-            <Map s="Mass" id="118" />
-            <Map s="Organism|Bone|Weight (tissue)" id="119" />
-            <Map s="M_bon" id="120" />
-            <Map s="Organism|Brain|Weight (tissue)" id="121" />
-            <Map s="M_brn" id="122" />
-            <Map s="Organism|Fat|Weight (tissue)" id="123" />
-            <Map s="M_fat" id="124" />
-            <Map s="Organism|Gonads|Weight (tissue)" id="125" />
-            <Map s="M_tes" id="126" />
-            <Map s="Organism|Heart|Weight (tissue)" id="127" />
-            <Map s="M_hrt" id="128" />
-            <Map s="Organism|Kidney|Weight (tissue)" id="129" />
-            <Map s="M_kid" id="130" />
-            <Map s="Organism|LargeIntestine|Weight (tissue)" id="131" />
-            <Map s="M_lin" id="132" />
-            <Map s="Organism|Liver|Weight (tissue)" id="133" />
-            <Map s="M_liv" id="134" />
-            <Map s="Organism|Lung|Weight (tissue)" id="135" />
-            <Map s="M_lng" id="136" />
-            <Map s="Organism|Muscle|Weight (tissue)" id="137" />
-            <Map s="M_mus" id="138" />
-            <Map s="Organism|Pancreas|Weight (tissue)" id="139" />
-            <Map s="M_pan" id="140" />
-            <Map s="Organism|PortalVein|Weight (tissue)" id="141" />
-            <Map s="M_pve" id="142" />
-            <Map s="Organism|Skin|Weight (tissue)" id="143" />
-            <Map s="M_skn" id="144" />
-            <Map s="Organism|SmallIntestine|Weight (tissue)" id="145" />
-            <Map s="M_sin" id="146" />
-            <Map s="Organism|Spleen|Weight (tissue)" id="147" />
-            <Map s="M_spl" id="148" />
-            <Map s="Organism|Stomach|Weight (tissue)" id="149" />
-            <Map s="M_sto" id="150" />
-            <Map s="Organism|VenousBlood|Weight (tissue)" id="151" />
-            <Map s="M_ven" id="152" />
-            <Map s="..|Age" id="153" />
-            <Map s="Age" id="154" />
-            <Map s="Age in years" id="155" />
-            <Map s="..|Gestational age" id="156" />
-            <Map s="GA" id="157" />
-            <Map s="Age in weeks" id="158" />
-            <Map s="Organism|Height" id="159" />
-            <Map s="Height" id="160" />
-            <Map s="Length" id="161" />
-            <Map s="Organism|Weight" id="162" />
-            <Map s="BW" id="163" />
-            <Map s="..|Density (tissue)" id="164" />
-            <Map s="Density" id="165" />
-            <Map s="..|Volume" id="166" />
-            <Map s="..|..|Fraction vascular" id="167" />
-            <Map s="f_vas" id="168" />
-            <Map s="..|..|Volume" id="169" />
-            <Map s="V" id="170" />
-            <Map s="MOLECULE|Ontogeny factor" id="171" />
-            <Map s="f_onto" id="172" />
-            <Map s="MOLECULE|Partition coefficient (blood cells/plasma)" id="173" />
-            <Map s="K_rbc" id="174" />
-            <Map s="..|Gallbladder ejection half-time" id="175" />
-            <Map s="EHC_HalfTime" id="176" />
-            <Map s="Time" id="177" />
-            <Map s="..|Specific blood flow rate" id="178" />
-            <Map s="Qspec" id="179" />
-            <Map s="Flow per weight organ" id="180" />
-            <Map s="..|Weight (tissue)" id="181" />
-            <Map s="Weight" id="182" />
-            <Map s="Organism|Thickness (endothelium)" id="183" />
-            <Map s="d_endo" id="184" />
-            <Map s="Neighborhoods|Bone_pls_Bone_int|Surface area (plasma/interstitial)" id="185" />
-            <Map s="SA_pls_int" id="186" />
-            <Map s="Area" id="187" />
-            <Map s="..|Fraction interstitial" id="188" />
-            <Map s="f_int" id="189" />
-            <Map s="..|Fraction vascular" id="190" />
-            <Map s="V_org" id="191" />
-            <Map s="..|..|Fraction interstitial" id="192" />
-            <Map s="Organism|pH (interstitial)" id="193" />
-            <Map s="pH_int" id="194" />
-            <Map s="Neighborhoods|Bone_int_Bone_cell|MOLECULE|Partition coefficient (interstitial/water)" id="195" />
-            <Map s="K_water_int" id="196" />
-            <Map s="..|..|Fraction intracellular" id="197" />
-            <Map s="f_cell" id="198" />
-            <Map s="Neighborhoods|Bone_int_Bone_cell|MOLECULE|Partition coefficient (intracellular/water)" id="199" />
-            <Map s="K_water_cell" id="200" />
-            <Map s="Neighborhoods|Brain_pls_Brain_int|Surface area (plasma/interstitial)" id="201" />
-            <Map s="Neighborhoods|Brain_int_Brain_cell|MOLECULE|Partition coefficient (interstitial/water)" id="202" />
-            <Map s="Neighborhoods|Brain_int_Brain_cell|MOLECULE|Partition coefficient (intracellular/water)" id="203" />
-            <Map s="Neighborhoods|Fat_pls_Fat_int|Surface area (plasma/interstitial)" id="204" />
-            <Map s="Neighborhoods|Fat_int_Fat_cell|MOLECULE|Partition coefficient (interstitial/water)" id="205" />
-            <Map s="Neighborhoods|Fat_int_Fat_cell|MOLECULE|Partition coefficient (intracellular/water)" id="206" />
-            <Map s="Neighborhoods|Gonads_pls_Gonads_int|Surface area (plasma/interstitial)" id="207" />
-            <Map s="Neighborhoods|Gonads_int_Gonads_cell|MOLECULE|Partition coefficient (interstitial/water)" id="208" />
-            <Map s="Neighborhoods|Gonads_int_Gonads_cell|MOLECULE|Partition coefficient (intracellular/water)" id="209" />
-            <Map s="Neighborhoods|Heart_pls_Heart_int|Surface area (plasma/interstitial)" id="210" />
-            <Map s="Neighborhoods|Heart_int_Heart_cell|MOLECULE|Partition coefficient (interstitial/water)" id="211" />
-            <Map s="Neighborhoods|Heart_int_Heart_cell|MOLECULE|Partition coefficient (intracellular/water)" id="212" />
-            <Map s="Neighborhoods|Kidney_pls_Kidney_int|Surface area (plasma/interstitial)" id="213" />
-            <Map s="Organism|Estimated gestational age" id="214" />
-            <Map s="PMA" id="215" />
-            <Map s="Organism|Kidney|fGFRpremat" id="216" />
-            <Map s="GFR_premat" id="217" />
-            <Map s="Organism|Kidney|GFRmat" id="218" />
-            <Map s="GFR_mat" id="219" />
-            <Map s="Flow" id="220" />
-            <Map s="Organism|Kidney|Hill coefficient for GFR" id="221" />
-            <Map s="Hill" id="222" />
-            <Map s="Organism|Kidney|TM50 for GFR" id="223" />
-            <Map s="TM50" id="224" />
-            <Map s="Organism|Kidney|Volume (standard kidney)" id="225" />
-            <Map s="V_kid_std" id="226" />
-            <Map s="Neighborhoods|Kidney_int_Kidney_cell|MOLECULE|Partition coefficient (interstitial/water)" id="227" />
-            <Map s="Neighborhoods|Kidney_int_Kidney_cell|MOLECULE|Partition coefficient (intracellular/water)" id="228" />
-            <Map s="..|Distal radius" id="229" />
-            <Map s="r2" id="230" />
-            <Map s="..|Length" id="231" />
-            <Map s="L" id="232" />
-            <Map s="..|Proximal radius" id="233" />
-            <Map s="r1" id="234" />
-            <Map s="..|Geometric surface area" id="235" />
-            <Map s="..|Thickness of gut wall" id="236" />
-            <Map s="d" id="237" />
-            <Map s="..|pH in fasted state" id="238" />
-            <Map s="pH_fasted" id="239" />
-            <Map s="..|Fractional steady state fill level" id="240" />
-            <Map s="SteadyStateFillLevel" id="241" />
-            <Map s="..|Inverse rate of inflow of liquid into stomach" id="242" />
-            <Map s="StomachInflowTime" id="243" />
-            <Map s="..|Fraction of geometric volume filled with liquid" id="244" />
-            <Map s="FillLevel" id="245" />
-            <Map s="..|Liquid" id="246" />
-            <Map s="Liquid" id="247" />
-            <Map s="..|Gastric emptying time" id="248" />
-            <Map s="GET" id="249" />
-            <Map s="..|FillLevelFlag" id="250" />
-            <Map s="FillLevelFlag" id="251" />
-            <Map s="..|Liquid transfer rate" id="252" />
-            <Map s="LT_sto" id="253" />
-            <Map s="..|Secretion of liquid" id="254" />
-            <Map s="Inflow" id="255" />
-            <Map s="..|..|OralApplicationsEnabled" id="256" />
-            <Map s="OralApplicationsEnabled" id="257" />
-            <Map s="..|Intestinal transit rate (absolute)" id="258" />
-            <Map s="w" id="259" />
-            <Map s="..|..|Duodenum|FillLevelFlag" id="260" />
-            <Map s="FillLevelFlagNext" id="261" />
-            <Map s="..|pKa_pH_WS_lum_F1" id="262" />
-            <Map s="F1" id="263" />
-            <Map s="..|pKa_pH_WS_lum_F2" id="264" />
-            <Map s="F2" id="265" />
-            <Map s="..|pKa_pH_WS_lum_F3" id="266" />
-            <Map s="F3" id="267" />
-            <Map s="MOLECULE|Compound type 2" id="268" />
-            <Map s="CT2" id="269" />
-            <Map s="MOLECULE|CT_NEUTRAL" id="270" />
-            <Map s="CT_NEUTRAL" id="271" />
-            <Map s="MOLECULE|pKa value 2" id="272" />
-            <Map s="pKa_2" id="273" />
-            <Map s="..|..|pH" id="274" />
-            <Map s="pH" id="275" />
-            <Map s="MOLECULE|Compound type 1" id="276" />
-            <Map s="CT1" id="277" />
-            <Map s="MOLECULE|pKa value 1" id="278" />
-            <Map s="pKa_1" id="279" />
-            <Map s="MOLECULE|Compound type 0" id="280" />
-            <Map s="CT0" id="281" />
-            <Map s="MOLECULE|pKa value 0" id="282" />
-            <Map s="pKa_0" id="283" />
-            <Map s="MOLECULE|Ontogeny factor GI" id="284" />
-            <Map s="..|pKa_pH_WS_lum_K1" id="285" />
-            <Map s="K1" id="286" />
-            <Map s="..|pKa_pH_WS_lum_K2" id="287" />
-            <Map s="K2" id="288" />
-            <Map s="..|pKa_pH_WS_lum_K3" id="289" />
-            <Map s="K3" id="290" />
-            <Map s="..|pKa_pH_WS_lum_K4" id="291" />
-            <Map s="K4" id="292" />
-            <Map s="..|pKa_pH_WS_lum_K5" id="293" />
-            <Map s="K5" id="294" />
-            <Map s="..|pKa_pH_WS_lum_K6" id="295" />
-            <Map s="K6" id="296" />
-            <Map s="..|pKa_pH_WS_lum_K7" id="297" />
-            <Map s="K7" id="298" />
-            <Map s="..|pKa_pH_WS_lum_K8" id="299" />
-            <Map s="K8" id="300" />
-            <Map s="MOLECULE|Solubility gain per charge" id="301" />
-            <Map s="base" id="302" />
-            <Map s="..|Solubility_pKa_pH_Factor" id="303" />
-            <Map s="Solubility_pKa_pH_Factor" id="304" />
-            <Map s="MOLECULE|Solubility at reference pH" id="305" />
-            <Map s="Solubility" id="306" />
-            <Map s="Concentration (mass)" id="307" />
-            <Map s="MOLECULE|Solubility_pKa_pH_Factor" id="308" />
-            <Map s="Solubility_pKa_REFpH_Factor" id="309" />
-            <Map s="..|..|..|Height" id="310" />
-            <Map s="..|r1_p0" id="311" />
-            <Map s="r1_p0" id="312" />
-            <Map s="..|r1_p1" id="313" />
-            <Map s="r1_p1" id="314" />
-            <Map s="alpha" id="315" />
-            <Map s="k" id="316" />
-            <Map s="inflow" id="317" />
-            <Map s="..|..|Stomach|Fractional steady state fill level" id="318" />
-            <Map s="alpha_p" id="319" />
-            <Map s="..|..|Stomach|Intestinal transit rate (absolute)" id="320" />
-            <Map s="k_p" id="321" />
-            <Map s="..|..|Stomach|Volume" id="322" />
-            <Map s="V_p" id="323" />
-            <Map s="..|r2_p0" id="324" />
-            <Map s="r2_p0" id="325" />
-            <Map s="..|r2_p1" id="326" />
-            <Map s="r2_p1" id="327" />
-            <Map s="..|Intestinal transit rate" id="328" />
-            <Map s="LuminalVelocity" id="329" />
-            <Map s="Organism|SmallIntestine|Small intestinal transit time factor" id="330" />
-            <Map s="SITT_fact" id="331" />
-            <Map s="..|L_p0" id="332" />
-            <Map s="L_p0" id="333" />
-            <Map s="..|L_p1" id="334" />
-            <Map s="L_p1" id="335" />
-            <Map s="..|..|UpperJejunum|FillLevelFlag" id="336" />
-            <Map s="..|Thickness_p1" id="337" />
-            <Map s="Thickness_p1" id="338" />
-            <Map s="..|Thickness_p2" id="339" />
-            <Map s="Thickness_p2" id="340" />
-            <Map s="..|Thickness_p3" id="341" />
-            <Map s="Thickness_p3" id="342" />
-            <Map s="Inversed length" id="343" />
-            <Map s="V_Intestine" id="344" />
-            <Map s="..|Absorption of liquid" id="345" />
-            <Map s="Outflow" id="346" />
-            <Map s="LT_duo" id="347" />
-            <Map s="..|..|Stomach|Liquid transfer rate" id="348" />
-            <Map s="Neighborhoods|Lumen_duo_Duodenum_pls|MOLECULE|Sum of active process rates" id="349" />
-            <Map s="ActiveRates_para" id="350" />
-            <Map s="Amount per time" id="351" />
-            <Map s="Neighborhoods|Lumen_duo_Duodenum_cell|MOLECULE|Sum of active process rates" id="352" />
-            <Map s="ActiveRates_trans" id="353" />
-            <Map s="Neighborhoods|Lumen_duo_Duodenum_pls|MOLECULE|Sum of passive process rates" id="354" />
-            <Map s="PassiveRates_para" id="355" />
-            <Map s="Neighborhoods|Lumen_duo_Duodenum_cell|MOLECULE|Sum of passive process rates" id="356" />
-            <Map s="PassiveRates_trans" id="357" />
-            <Map s="..|..|LowerJejunum|FillLevelFlag" id="358" />
-            <Map s="LT_uje" id="359" />
-            <Map s="..|..|Duodenum|Liquid transfer rate" id="360" />
-            <Map s="..|..|Duodenum|Fractional steady state fill level" id="361" />
-            <Map s="..|..|Duodenum|Intestinal transit rate (absolute)" id="362" />
-            <Map s="..|..|Duodenum|Volume" id="363" />
-            <Map s="Neighborhoods|Lumen_uje_UpperJejunum_pls|MOLECULE|Sum of active process rates" id="364" />
-            <Map s="Neighborhoods|Lumen_uje_UpperJejunum_cell|MOLECULE|Sum of active process rates" id="365" />
-            <Map s="Neighborhoods|Lumen_uje_UpperJejunum_pls|MOLECULE|Sum of passive process rates" id="366" />
-            <Map s="Neighborhoods|Lumen_uje_UpperJejunum_cell|MOLECULE|Sum of passive process rates" id="367" />
-            <Map s="..|..|UpperJejunum|Fractional steady state fill level" id="368" />
-            <Map s="..|..|UpperJejunum|Intestinal transit rate (absolute)" id="369" />
-            <Map s="..|..|UpperJejunum|Volume" id="370" />
-            <Map s="LT_lje" id="371" />
-            <Map s="..|..|UpperJejunum|Liquid transfer rate" id="372" />
-            <Map s="..|..|UpperIleum|FillLevelFlag" id="373" />
-            <Map s="Neighborhoods|Lumen_lje_LowerJejunum_pls|MOLECULE|Sum of active process rates" id="374" />
-            <Map s="Neighborhoods|Lumen_lje_LowerJejunum_cell|MOLECULE|Sum of active process rates" id="375" />
-            <Map s="Neighborhoods|Lumen_lje_LowerJejunum_pls|MOLECULE|Sum of passive process rates" id="376" />
-            <Map s="Neighborhoods|Lumen_lje_LowerJejunum_cell|MOLECULE|Sum of passive process rates" id="377" />
-            <Map s="..|..|LowerJejunum|Fractional steady state fill level" id="378" />
-            <Map s="..|..|LowerJejunum|Intestinal transit rate (absolute)" id="379" />
-            <Map s="..|..|LowerJejunum|Volume" id="380" />
-            <Map s="LT_uil" id="381" />
-            <Map s="..|..|LowerJejunum|Liquid transfer rate" id="382" />
-            <Map s="..|..|LowerIleum|FillLevelFlag" id="383" />
-            <Map s="Neighborhoods|Lumen_uil_UpperIleum_pls|MOLECULE|Sum of active process rates" id="384" />
-            <Map s="Neighborhoods|Lumen_uil_UpperIleum_cell|MOLECULE|Sum of active process rates" id="385" />
-            <Map s="Neighborhoods|Lumen_uil_UpperIleum_pls|MOLECULE|Sum of passive process rates" id="386" />
-            <Map s="Neighborhoods|Lumen_uil_UpperIleum_cell|MOLECULE|Sum of passive process rates" id="387" />
-            <Map s="..|..|UpperIleum|Fractional steady state fill level" id="388" />
-            <Map s="..|..|UpperIleum|Intestinal transit rate (absolute)" id="389" />
-            <Map s="..|..|UpperIleum|Volume" id="390" />
-            <Map s="LT_lil" id="391" />
-            <Map s="..|..|UpperIleum|Liquid transfer rate" id="392" />
-            <Map s="..|..|Caecum|FillLevelFlag" id="393" />
-            <Map s="Neighborhoods|Lumen_lil_LowerIleum_pls|MOLECULE|Sum of active process rates" id="394" />
-            <Map s="Neighborhoods|Lumen_lil_LowerIleum_cell|MOLECULE|Sum of active process rates" id="395" />
-            <Map s="Neighborhoods|Lumen_lil_LowerIleum_pls|MOLECULE|Sum of passive process rates" id="396" />
-            <Map s="Neighborhoods|Lumen_lil_LowerIleum_cell|MOLECULE|Sum of passive process rates" id="397" />
-            <Map s="..|..|LowerIleum|Fractional steady state fill level" id="398" />
-            <Map s="..|..|LowerIleum|Intestinal transit rate (absolute)" id="399" />
-            <Map s="..|..|LowerIleum|Volume" id="400" />
-            <Map s="Organism|LargeIntestine|Large intestinal transit time factor" id="401" />
-            <Map s="LITT_fact" id="402" />
-            <Map s="LT_cae" id="403" />
-            <Map s="..|..|LowerIleum|Liquid transfer rate" id="404" />
-            <Map s="..|..|ColonAscendens|FillLevelFlag" id="405" />
-            <Map s="Neighborhoods|Lumen_cae_Caecum_pls|MOLECULE|Sum of active process rates" id="406" />
-            <Map s="Neighborhoods|Lumen_cae_Caecum_cell|MOLECULE|Sum of active process rates" id="407" />
-            <Map s="Neighborhoods|Lumen_cae_Caecum_pls|MOLECULE|Sum of passive process rates" id="408" />
-            <Map s="Neighborhoods|Lumen_cae_Caecum_cell|MOLECULE|Sum of passive process rates" id="409" />
-            <Map s="..|..|Caecum|Fractional steady state fill level" id="410" />
-            <Map s="..|..|Caecum|Intestinal transit rate (absolute)" id="411" />
-            <Map s="..|..|Caecum|Volume" id="412" />
-            <Map s="LT_colasc" id="413" />
-            <Map s="..|..|Caecum|Liquid transfer rate" id="414" />
-            <Map s="..|..|ColonTransversum|FillLevelFlag" id="415" />
-            <Map s="Neighborhoods|Lumen_colasc_ColonAscendens_pls|MOLECULE|Sum of active process rates" id="416" />
-            <Map s="Neighborhoods|Lumen_colasc_ColonAscendens_cell|MOLECULE|Sum of active process rates" id="417" />
-            <Map s="Neighborhoods|Lumen_colasc_ColonAscendens_pls|MOLECULE|Sum of passive process rates" id="418" />
-            <Map s="Neighborhoods|Lumen_colasc_ColonAscendens_cell|MOLECULE|Sum of passive process rates" id="419" />
-            <Map s="..|..|ColonDescendens|FillLevelFlag" id="420" />
-            <Map s="LT_coltrans" id="421" />
-            <Map s="..|..|ColonAscendens|Liquid transfer rate" id="422" />
-            <Map s="..|..|ColonAscendens|Fractional steady state fill level" id="423" />
-            <Map s="..|..|ColonAscendens|Intestinal transit rate (absolute)" id="424" />
-            <Map s="..|..|ColonAscendens|Volume" id="425" />
-            <Map s="Neighborhoods|Lumen_coltrans_ColonTransversum_pls|MOLECULE|Sum of active process rates" id="426" />
-            <Map s="Neighborhoods|Lumen_coltrans_ColonTransversum_cell|MOLECULE|Sum of active process rates" id="427" />
-            <Map s="Neighborhoods|Lumen_coltrans_ColonTransversum_pls|MOLECULE|Sum of passive process rates" id="428" />
-            <Map s="Neighborhoods|Lumen_coltrans_ColonTransversum_cell|MOLECULE|Sum of passive process rates" id="429" />
-            <Map s="LT_coldesc" id="430" />
-            <Map s="..|..|ColonTransversum|Liquid transfer rate" id="431" />
-            <Map s="..|..|ColonSigmoid|FillLevelFlag" id="432" />
-            <Map s="..|..|ColonTransversum|Fractional steady state fill level" id="433" />
-            <Map s="..|..|ColonTransversum|Intestinal transit rate (absolute)" id="434" />
-            <Map s="..|..|ColonTransversum|Volume" id="435" />
-            <Map s="Neighborhoods|Lumen_coldesc_ColonDescendens_pls|MOLECULE|Sum of active process rates" id="436" />
-            <Map s="Neighborhoods|Lumen_coldesc_ColonDescendens_cell|MOLECULE|Sum of active process rates" id="437" />
-            <Map s="Neighborhoods|Lumen_coldesc_ColonDescendens_pls|MOLECULE|Sum of passive process rates" id="438" />
-            <Map s="Neighborhoods|Lumen_coldesc_ColonDescendens_cell|MOLECULE|Sum of passive process rates" id="439" />
-            <Map s="..|..|ColonDescendens|Fractional steady state fill level" id="440" />
-            <Map s="..|..|ColonDescendens|Intestinal transit rate (absolute)" id="441" />
-            <Map s="..|..|ColonDescendens|Volume" id="442" />
-            <Map s="LT_colsigm" id="443" />
-            <Map s="..|..|ColonDescendens|Liquid transfer rate" id="444" />
-            <Map s="..|..|Rectum|FillLevelFlag" id="445" />
-            <Map s="Neighborhoods|Lumen_colsigm_ColonSigmoid_pls|MOLECULE|Sum of active process rates" id="446" />
-            <Map s="Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|MOLECULE|Sum of active process rates" id="447" />
-            <Map s="Neighborhoods|Lumen_colsigm_ColonSigmoid_pls|MOLECULE|Sum of passive process rates" id="448" />
-            <Map s="Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|MOLECULE|Sum of passive process rates" id="449" />
-            <Map s="..|..|ColonSigmoid|Fractional steady state fill level" id="450" />
-            <Map s="..|..|ColonSigmoid|Intestinal transit rate (absolute)" id="451" />
-            <Map s="..|..|ColonSigmoid|Volume" id="452" />
-            <Map s="LT_rect" id="453" />
-            <Map s="..|..|ColonSigmoid|Liquid transfer rate" id="454" />
-            <Map s="Neighborhoods|Lumen_rect_Rectum_pls|MOLECULE|Sum of active process rates" id="455" />
-            <Map s="Neighborhoods|Lumen_rect_Rectum_cell|MOLECULE|Sum of active process rates" id="456" />
-            <Map s="Neighborhoods|Lumen_rect_Rectum_pls|MOLECULE|Sum of passive process rates" id="457" />
-            <Map s="Neighborhoods|Lumen_rect_Rectum_cell|MOLECULE|Sum of passive process rates" id="458" />
-            <Map s="..|..|Rectum|Liquid transfer rate" id="459" />
-            <Map s="LT_rec" id="460" />
-            <Map s="Neighborhoods|Stomach_pls_Stomach_int|Surface area (plasma/interstitial)" id="461" />
-            <Map s="Neighborhoods|Stomach_int_Stomach_cell|MOLECULE|Partition coefficient (interstitial/water)" id="462" />
-            <Map s="Neighborhoods|Stomach_int_Stomach_cell|MOLECULE|Partition coefficient (intracellular/water)" id="463" />
-            <Map s="..|Small intestinal transit time" id="464" />
-            <Map s="SITT" id="465" />
-            <Map s="..|Small intestinal transit time factor intercept" id="466" />
-            <Map s="P2" id="467" />
-            <Map s="..|Small intestinal transit time factor slope" id="468" />
-            <Map s="P1" id="469" />
-            <Map s="..|Lymph flow rate (incl. mucosa)" id="470" />
-            <Map s="Q_lymph_incl_Mucosa" id="471" />
-            <Map s="..|Mucosa|Duodenum|Lymph flow rate" id="472" />
-            <Map s="Q_lymph_duo" id="473" />
-            <Map s="..|Mucosa|LowerIleum|Lymph flow rate" id="474" />
-            <Map s="Q_lymph_lil" id="475" />
-            <Map s="..|Mucosa|LowerJejunum|Lymph flow rate" id="476" />
-            <Map s="Q_lymph_lje" id="477" />
-            <Map s="..|Mucosa|UpperIleum|Lymph flow rate" id="478" />
-            <Map s="Q_lymph_uil" id="479" />
-            <Map s="..|Mucosa|UpperJejunum|Lymph flow rate" id="480" />
-            <Map s="Q_lymph_uje" id="481" />
-            <Map s="Neighborhoods|SmallIntestine_pls_SmallIntestine_int|Surface area (plasma/interstitial)" id="482" />
-            <Map s="..|Fluid recirculation flow rate (incl. mucosa)" id="483" />
-            <Map s="J_iso_incl_Mucosa" id="484" />
-            <Map s="..|Mucosa|Duodenum|Fluid recirculation flow rate" id="485" />
-            <Map s="J_iso_duo" id="486" />
-            <Map s="..|Mucosa|LowerIleum|Fluid recirculation flow rate" id="487" />
-            <Map s="J_iso_lil" id="488" />
-            <Map s="..|Mucosa|LowerJejunum|Fluid recirculation flow rate" id="489" />
-            <Map s="J_iso_lje" id="490" />
-            <Map s="..|Mucosa|UpperIleum|Fluid recirculation flow rate" id="491" />
-            <Map s="J_iso_uil" id="492" />
-            <Map s="..|Mucosa|UpperJejunum|Fluid recirculation flow rate" id="493" />
-            <Map s="J_iso_uje" id="494" />
-            <Map s="..|Mucosa|Duodenum|Volume" id="495" />
-            <Map s="V_duo" id="496" />
-            <Map s="..|Mucosa|LowerIleum|Volume" id="497" />
-            <Map s="V_lil" id="498" />
-            <Map s="..|Mucosa|LowerJejunum|Volume" id="499" />
-            <Map s="V_lje" id="500" />
-            <Map s="..|Mucosa|UpperIleum|Volume" id="501" />
-            <Map s="V_uil" id="502" />
-            <Map s="..|Mucosa|UpperJejunum|Volume" id="503" />
-            <Map s="V_uje" id="504" />
-            <Map s="..|..|Volume (mucosa)" id="505" />
-            <Map s="V_Mucosa" id="506" />
-            <Map s="Neighborhoods|SmallIntestine_int_SmallIntestine_cell|MOLECULE|Partition coefficient (interstitial/water)" id="507" />
-            <Map s="Neighborhoods|SmallIntestine_int_SmallIntestine_cell|MOLECULE|Partition coefficient (intracellular/water)" id="508" />
-            <Map s="..|Fraction mucosa" id="509" />
-            <Map s="fractionMucosa" id="510" />
-            <Map s="..|..|..|..|Lumen|Duodenum|Volume (gut wall)" id="511" />
-            <Map s="V_GutWall" id="512" />
-            <Map s="Neighborhoods|Duodenum_pls_Duodenum_int|Surface area (plasma/interstitial)" id="513" />
-            <Map s="..|..|..|Lymph flow rate (incl. mucosa)" id="514" />
-            <Map s="Q_lymph_intestine" id="515" />
-            <Map s="..|..|..|Volume" id="516" />
-            <Map s="V_intestine" id="517" />
-            <Map s="V_seg" id="518" />
-            <Map s="..|..|..|Fluid recirculation flow rate (incl. mucosa)" id="519" />
-            <Map s="J_iso_intestine" id="520" />
-            <Map s="..|..|..|Blood flow rate" id="521" />
-            <Map s="Q" id="522" />
-            <Map s="..|Fraction of regional blood flow rate" id="523" />
-            <Map s="regionalFractQ" id="524" />
-            <Map s="..|..|..|Mucosa blood flow fraction" id="525" />
-            <Map s="fractQ" id="526" />
-            <Map s="Neighborhoods|Duodenum_int_Duodenum_cell|MOLECULE|Partition coefficient (interstitial/water)" id="527" />
-            <Map s="Neighborhoods|Duodenum_int_Duodenum_cell|MOLECULE|Partition coefficient (intracellular/water)" id="528" />
-            <Map s="..|..|..|..|Lumen|UpperJejunum|Volume (gut wall)" id="529" />
-            <Map s="Neighborhoods|UpperJejunum_pls_UpperJejunum_int|Surface area (plasma/interstitial)" id="530" />
-            <Map s="Neighborhoods|UpperJejunum_int_UpperJejunum_cell|MOLECULE|Partition coefficient (interstitial/water)" id="531" />
-            <Map s="Neighborhoods|UpperJejunum_int_UpperJejunum_cell|MOLECULE|Partition coefficient (intracellular/water)" id="532" />
-            <Map s="..|..|..|..|Lumen|LowerJejunum|Volume (gut wall)" id="533" />
-            <Map s="Neighborhoods|LowerJejunum_pls_LowerJejunum_int|Surface area (plasma/interstitial)" id="534" />
-            <Map s="Neighborhoods|LowerJejunum_int_LowerJejunum_cell|MOLECULE|Partition coefficient (interstitial/water)" id="535" />
-            <Map s="Neighborhoods|LowerJejunum_int_LowerJejunum_cell|MOLECULE|Partition coefficient (intracellular/water)" id="536" />
-            <Map s="..|..|..|..|Lumen|UpperIleum|Volume (gut wall)" id="537" />
-            <Map s="Neighborhoods|UpperIleum_pls_UpperIleum_int|Surface area (plasma/interstitial)" id="538" />
-            <Map s="Neighborhoods|UpperIleum_int_UpperIleum_cell|MOLECULE|Partition coefficient (interstitial/water)" id="539" />
-            <Map s="Neighborhoods|UpperIleum_int_UpperIleum_cell|MOLECULE|Partition coefficient (intracellular/water)" id="540" />
-            <Map s="..|..|..|..|Lumen|LowerIleum|Volume (gut wall)" id="541" />
-            <Map s="Neighborhoods|LowerIleum_pls_LowerIleum_int|Surface area (plasma/interstitial)" id="542" />
-            <Map s="Neighborhoods|LowerIleum_int_LowerIleum_cell|MOLECULE|Partition coefficient (interstitial/water)" id="543" />
-            <Map s="Neighborhoods|LowerIleum_int_LowerIleum_cell|MOLECULE|Partition coefficient (intracellular/water)" id="544" />
-            <Map s="..|Mucosa|Caecum|Volume" id="545" />
-            <Map s="V_cae" id="546" />
-            <Map s="..|Mucosa|ColonAscendens|Volume" id="547" />
-            <Map s="V_ca" id="548" />
-            <Map s="..|Mucosa|ColonDescendens|Volume" id="549" />
-            <Map s="V_cd" id="550" />
-            <Map s="..|Mucosa|ColonSigmoid|Volume" id="551" />
-            <Map s="V_cs" id="552" />
-            <Map s="..|Mucosa|ColonTransversum|Volume" id="553" />
-            <Map s="V_ct" id="554" />
-            <Map s="..|Mucosa|Rectum|Volume" id="555" />
-            <Map s="V_rec" id="556" />
-            <Map s="..|Large intestinal transit time" id="557" />
-            <Map s="LITT" id="558" />
-            <Map s="..|Large intestinal transit time factor intercept" id="559" />
-            <Map s="..|Large intestinal transit time factor slope" id="560" />
-            <Map s="..|Mucosa|Caecum|Fluid recirculation flow rate" id="561" />
-            <Map s="J_iso_cae" id="562" />
-            <Map s="..|Mucosa|ColonAscendens|Fluid recirculation flow rate" id="563" />
-            <Map s="J_iso_colasc" id="564" />
-            <Map s="..|Mucosa|ColonDescendens|Fluid recirculation flow rate" id="565" />
-            <Map s="J_iso_coldesc" id="566" />
-            <Map s="..|Mucosa|ColonSigmoid|Fluid recirculation flow rate" id="567" />
-            <Map s="J_iso_colsigm" id="568" />
-            <Map s="..|Mucosa|ColonTransversum|Fluid recirculation flow rate" id="569" />
-            <Map s="J_iso_coltrans" id="570" />
-            <Map s="..|Mucosa|Rectum|Fluid recirculation flow rate" id="571" />
-            <Map s="J_iso_rect" id="572" />
-            <Map s="..|Mucosa|Caecum|Lymph flow rate" id="573" />
-            <Map s="Q_lymph_cae" id="574" />
-            <Map s="..|Mucosa|ColonAscendens|Lymph flow rate" id="575" />
-            <Map s="Q_lymph_colasc" id="576" />
-            <Map s="..|Mucosa|ColonDescendens|Lymph flow rate" id="577" />
-            <Map s="Q_lymph_coldesc" id="578" />
-            <Map s="..|Mucosa|ColonSigmoid|Lymph flow rate" id="579" />
-            <Map s="Q_lymph_colsigm" id="580" />
-            <Map s="..|Mucosa|ColonTransversum|Lymph flow rate" id="581" />
-            <Map s="Q_lymph_coltrans" id="582" />
-            <Map s="..|Mucosa|Rectum|Lymph flow rate" id="583" />
-            <Map s="Q_lymph_rect" id="584" />
-            <Map s="Neighborhoods|LargeIntestine_pls_LargeIntestine_int|Surface area (plasma/interstitial)" id="585" />
-            <Map s="Neighborhoods|LargeIntestine_int_LargeIntestine_cell|MOLECULE|Partition coefficient (interstitial/water)" id="586" />
-            <Map s="Neighborhoods|LargeIntestine_int_LargeIntestine_cell|MOLECULE|Partition coefficient (intracellular/water)" id="587" />
-            <Map s="..|..|..|..|Lumen|Caecum|Volume (gut wall)" id="588" />
-            <Map s="Neighborhoods|Caecum_pls_Caecum_int|Surface area (plasma/interstitial)" id="589" />
-            <Map s="Neighborhoods|Caecum_int_Caecum_cell|MOLECULE|Partition coefficient (interstitial/water)" id="590" />
-            <Map s="Neighborhoods|Caecum_int_Caecum_cell|MOLECULE|Partition coefficient (intracellular/water)" id="591" />
-            <Map s="..|..|..|..|Lumen|ColonAscendens|Volume (gut wall)" id="592" />
-            <Map s="Neighborhoods|ColonAscendens_pls_ColonAscendens_int|Surface area (plasma/interstitial)" id="593" />
-            <Map s="Neighborhoods|ColonAscendens_int_ColonAscendens_cell|MOLECULE|Partition coefficient (interstitial/water)" id="594" />
-            <Map s="Neighborhoods|ColonAscendens_int_ColonAscendens_cell|MOLECULE|Partition coefficient (intracellular/water)" id="595" />
-            <Map s="..|..|..|..|Lumen|ColonTransversum|Volume (gut wall)" id="596" />
-            <Map s="Neighborhoods|ColonTransversum_pls_ColonTransversum_int|Surface area (plasma/interstitial)" id="597" />
-            <Map s="Neighborhoods|ColonTransversum_int_ColonTransversum_cell|MOLECULE|Partition coefficient (interstitial/water)" id="598" />
-            <Map s="Neighborhoods|ColonTransversum_int_ColonTransversum_cell|MOLECULE|Partition coefficient (intracellular/water)" id="599" />
-            <Map s="..|..|..|..|Lumen|ColonDescendens|Volume (gut wall)" id="600" />
-            <Map s="Neighborhoods|ColonDescendens_pls_ColonDescendens_int|Surface area (plasma/interstitial)" id="601" />
-            <Map s="Neighborhoods|ColonDescendens_int_ColonDescendens_cell|MOLECULE|Partition coefficient (interstitial/water)" id="602" />
-            <Map s="Neighborhoods|ColonDescendens_int_ColonDescendens_cell|MOLECULE|Partition coefficient (intracellular/water)" id="603" />
-            <Map s="..|..|..|..|Lumen|ColonSigmoid|Volume (gut wall)" id="604" />
-            <Map s="Neighborhoods|ColonSigmoid_pls_ColonSigmoid_int|Surface area (plasma/interstitial)" id="605" />
-            <Map s="Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|MOLECULE|Partition coefficient (interstitial/water)" id="606" />
-            <Map s="Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|MOLECULE|Partition coefficient (intracellular/water)" id="607" />
-            <Map s="..|..|..|..|Lumen|Rectum|Volume (gut wall)" id="608" />
-            <Map s="Neighborhoods|Rectum_pls_Rectum_int|Surface area (plasma/interstitial)" id="609" />
-            <Map s="Neighborhoods|Rectum_int_Rectum_cell|MOLECULE|Partition coefficient (interstitial/water)" id="610" />
-            <Map s="Neighborhoods|Rectum_int_Rectum_cell|MOLECULE|Partition coefficient (intracellular/water)" id="611" />
-            <Map s="Neighborhoods|Liver_pls_Liver_int|Surface area (plasma/interstitial)" id="612" />
-            <Map s="Neighborhoods|Liver_int_Liver_cell|MOLECULE|Partition coefficient (interstitial/water)" id="613" />
-            <Map s="Neighborhoods|Liver_int_Liver_cell|MOLECULE|Partition coefficient (intracellular/water)" id="614" />
-            <Map s="Neighborhoods|Lung_pls_Lung_int|Surface area (plasma/interstitial)" id="615" />
-            <Map s="Organism|Bone|Blood flow rate" id="616" />
-            <Map s="Q_bon" id="617" />
-            <Map s="Organism|Brain|Blood flow rate" id="618" />
-            <Map s="Q_brn" id="619" />
-            <Map s="Organism|Fat|Blood flow rate" id="620" />
-            <Map s="Q_fat" id="621" />
-            <Map s="Organism|Gonads|Blood flow rate" id="622" />
-            <Map s="Q_tes" id="623" />
-            <Map s="Organism|Heart|Blood flow rate" id="624" />
-            <Map s="Q_hrt" id="625" />
-            <Map s="Organism|Kidney|Blood flow rate" id="626" />
-            <Map s="Q_kid" id="627" />
-            <Map s="Organism|LargeIntestine|Blood flow rate" id="628" />
-            <Map s="Q_lin" id="629" />
-            <Map s="Organism|Liver|Blood flow rate" id="630" />
-            <Map s="Q_liv" id="631" />
-            <Map s="Organism|Muscle|Blood flow rate" id="632" />
-            <Map s="Q_mus" id="633" />
-            <Map s="Organism|Pancreas|Blood flow rate" id="634" />
-            <Map s="Q_pan" id="635" />
-            <Map s="Organism|Skin|Blood flow rate" id="636" />
-            <Map s="Q_skn" id="637" />
-            <Map s="Organism|SmallIntestine|Blood flow rate" id="638" />
-            <Map s="Q_sin" id="639" />
-            <Map s="Organism|Spleen|Blood flow rate" id="640" />
-            <Map s="Q_spl" id="641" />
-            <Map s="Organism|Stomach|Blood flow rate" id="642" />
-            <Map s="Q_sto" id="643" />
-            <Map s="Neighborhoods|Lung_int_Lung_cell|MOLECULE|Partition coefficient (interstitial/water)" id="644" />
-            <Map s="Neighborhoods|Lung_int_Lung_cell|MOLECULE|Partition coefficient (intracellular/water)" id="645" />
-            <Map s="Neighborhoods|Muscle_pls_Muscle_int|Surface area (plasma/interstitial)" id="646" />
-            <Map s="Neighborhoods|Muscle_int_Muscle_cell|MOLECULE|Partition coefficient (interstitial/water)" id="647" />
-            <Map s="Neighborhoods|Muscle_int_Muscle_cell|MOLECULE|Partition coefficient (intracellular/water)" id="648" />
-            <Map s="Neighborhoods|Pancreas_pls_Pancreas_int|Surface area (plasma/interstitial)" id="649" />
-            <Map s="Neighborhoods|Pancreas_int_Pancreas_cell|MOLECULE|Partition coefficient (interstitial/water)" id="650" />
-            <Map s="Neighborhoods|Pancreas_int_Pancreas_cell|MOLECULE|Partition coefficient (intracellular/water)" id="651" />
-            <Map s="Organism|LargeIntestine|Lymph flow rate (incl. mucosa)" id="652" />
-            <Map s="Q_Lymph_lin_incl_Mucosa" id="653" />
-            <Map s="Organism|Pancreas|Lymph flow rate" id="654" />
-            <Map s="Q_Lymph_pan" id="655" />
-            <Map s="Organism|SmallIntestine|Lymph flow rate (incl. mucosa)" id="656" />
-            <Map s="Q_Lymph_sin_incl_Mucosa" id="657" />
-            <Map s="Organism|Spleen|Lymph flow rate" id="658" />
-            <Map s="Q_Lymph_spl" id="659" />
-            <Map s="Organism|Stomach|Lymph flow rate" id="660" />
-            <Map s="Q_Lymph_sto" id="661" />
-            <Map s="Neighborhoods|Skin_pls_Skin_int|Surface area (plasma/interstitial)" id="662" />
-            <Map s="Neighborhoods|Skin_int_Skin_cell|MOLECULE|Partition coefficient (interstitial/water)" id="663" />
-            <Map s="Neighborhoods|Skin_int_Skin_cell|MOLECULE|Partition coefficient (intracellular/water)" id="664" />
-            <Map s="Neighborhoods|Spleen_pls_Spleen_int|Surface area (plasma/interstitial)" id="665" />
-            <Map s="Neighborhoods|Spleen_int_Spleen_cell|MOLECULE|Partition coefficient (interstitial/water)" id="666" />
-            <Map s="Neighborhoods|Spleen_int_Spleen_cell|MOLECULE|Partition coefficient (intracellular/water)" id="667" />
-            <Map s="Organism|Saliva|Volume" id="668" />
-            <Map s="V_slv" id="669" />
-            <Map s="FIRST_NEIGHBOR|..|Volume" id="670" />
-            <Map s="Organism|Surface/Volume ratio (blood cells)" id="671" />
-            <Map s="A_to_V_bc" id="672" />
-            <Map s="FIRST_NEIGHBOR|..|Fraction vascular" id="673" />
-            <Map s="f_vas_org" id="674" />
-            <Map s="Organism|SA proportionality factor" id="675" />
-            <Map s="..|Partition coefficient (intracellular/plasma)" id="676" />
-            <Map s="K_cell_pls" id="677" />
-            <Map s="..|P_int_cell_factor" id="678" />
-            <Map s="P_int_cell_factor" id="679" />
-            <Map s="..|P_cell_int_factor" id="680" />
-            <Map s="P_cell_int_factor" id="681" />
-            <Map s="..|P (interstitial-&gt;intracellular)" id="682" />
-            <Map s="P_int_cell" id="683" />
-            <Map s="..|..|Surface area (interstitial/intracellular)" id="684" />
-            <Map s="SA" id="685" />
-            <Map s="..|P (intracellular-&gt;interstitial)" id="686" />
-            <Map s="P_cell_int" id="687" />
-            <Map s="FIRST_NEIGHBOR|MOLECULE|Concentration" id="688" />
-            <Map s="C_pls" id="689" />
-            <Map s="Concentration (molar)" id="690" />
-            <Map s="FIRST_NEIGHBOR|..|Blood flow rate" id="691" />
-            <Map s="..|pKa_pH_WS_cell_F1" id="692" />
-            <Map s="..|pKa_pH_WS_cell_F2" id="693" />
-            <Map s="..|pKa_pH_WS_cell_F3" id="694" />
-            <Map s="FIRST_NEIGHBOR|Effective surface area enhancement factor" id="695" />
-            <Map s="AeffFactor" id="696" />
-            <Map s="FIRST_NEIGHBOR|Geometric surface area" id="697" />
-            <Map s="Ageom" id="698" />
-            <Map s="FIRST_NEIGHBOR|Liquid" id="699" />
-            <Map s="FIRST_NEIGHBOR|MOLECULE" id="700" />
-            <Map s="DrugLiquid" id="701" />
-            <Map s="Amount" id="702" />
-            <Map s="SECOND_NEIGHBOR|MOLECULE|Concentration" id="703" />
-            <Map s="DrugMucosa" id="704" />
-            <Map s="MOLECULE|Intestinal permeability (transcellular)" id="705" />
-            <Map s="MOLECULE|Molecular weight" id="706" />
-            <Map s="MW" id="707" />
-            <Map s="Molecular weight" id="708" />
-            <Map s="NEIGHBORHOOD|MOLECULE|P_int_trans_cell_lum_factor" id="709" />
-            <Map s="P_int_trans_cell_lum_factor" id="710" />
-            <Map s="NEIGHBORHOOD|MOLECULE|P_int_trans_lum_cell_factor" id="711" />
-            <Map s="P_int_trans_lum_cell_factor" id="712" />
-            <Map s="FIRST_NEIGHBOR|MOLECULE|Solubility" id="713" />
-            <Map s="FIRST_NEIGHBOR|..|OralApplicationsEnabled" id="714" />
-            <Map s="FIRST_NEIGHBOR|..|Transcellular absorption sink condition" id="715" />
-            <Map s="SinkCondition_trans" id="716" />
-            <Map s="..|pKa_pH_WS_cell_K1" id="717" />
-            <Map s="..|pKa_pH_WS_cell_K2" id="718" />
-            <Map s="..|pKa_pH_WS_cell_K3" id="719" />
-            <Map s="..|pKa_pH_WS_cell_K4" id="720" />
-            <Map s="..|pKa_pH_WS_cell_K5" id="721" />
-            <Map s="..|pKa_pH_WS_cell_K6" id="722" />
-            <Map s="..|pKa_pH_WS_cell_K7" id="723" />
-            <Map s="..|pKa_pH_WS_cell_K8" id="724" />
-            <Map s="MOLECULE|base_For_Pint_Factor" id="725" />
-            <Map s="MOLECULE|Use pH- and pKa-dependent penalty factor for charged molecule fraction" id="726" />
-            <Map s="UsePenaltyFactor" id="727" />
-            <Map s="Neighborhoods|UpperJejunum_int_UpperJejunum_cell|MOLECULE|Partition coefficient (intracellular/plasma)" id="728" />
-            <Map s="SECOND_NEIGHBOR|pH" id="729" />
-            <Map s="FIRST_NEIGHBOR|pH" id="730" />
-            <Map s="MOLECULE|Intestinal permeability (paracellular)" id="731" />
-            <Map s="P_int_para" id="732" />
-            <Map s="FIRST_NEIGHBOR|..|Paracellular absorption sink condition" id="733" />
-            <Map s="SinkCondition_para" id="734" />
-            <Map s="C_bc" id="735" />
-            <Map s="Organism|Lumen|Caecum|MOLECULE|Oral mass absorbed segment" id="736" />
-            <Map s="MAbs_cae" id="737" />
-            <Map s="Organism|Lumen|ColonAscendens|MOLECULE|Oral mass absorbed segment" id="738" />
-            <Map s="MAbs_colasc" id="739" />
-            <Map s="Organism|Lumen|ColonDescendens|MOLECULE|Oral mass absorbed segment" id="740" />
-            <Map s="MAbs_coldesc" id="741" />
-            <Map s="Organism|Lumen|ColonSigmoid|MOLECULE|Oral mass absorbed segment" id="742" />
-            <Map s="MAbs_colsigm" id="743" />
-            <Map s="Organism|Lumen|ColonTransversum|MOLECULE|Oral mass absorbed segment" id="744" />
-            <Map s="MAbs_coltrans" id="745" />
-            <Map s="Organism|Lumen|Duodenum|MOLECULE|Oral mass absorbed segment" id="746" />
-            <Map s="MAbs_duo" id="747" />
-            <Map s="Organism|Lumen|LowerIleum|MOLECULE|Oral mass absorbed segment" id="748" />
-            <Map s="MAbs_lil" id="749" />
-            <Map s="Organism|Lumen|LowerJejunum|MOLECULE|Oral mass absorbed segment" id="750" />
-            <Map s="MAbs_lje" id="751" />
-            <Map s="Organism|Lumen|Rectum|MOLECULE|Oral mass absorbed segment" id="752" />
-            <Map s="MAbs_rect" id="753" />
-            <Map s="Organism|Lumen|UpperIleum|MOLECULE|Oral mass absorbed segment" id="754" />
-            <Map s="MAbs_uil" id="755" />
-            <Map s="Organism|Lumen|UpperJejunum|MOLECULE|Oral mass absorbed segment" id="756" />
-            <Map s="MAbs_uje" id="757" />
-            <Map s="Neighborhoods|LowerJejunum_int_LowerJejunum_cell|MOLECULE|Partition coefficient (intracellular/plasma)" id="758" />
-            <Map s="Neighborhoods|UpperIleum_int_UpperIleum_cell|MOLECULE|Partition coefficient (intracellular/plasma)" id="759" />
-            <Map s="SECOND_NEIGHBOR|..|Blood flow rate" id="760" />
-            <Map s="Neighborhoods|LowerIleum_int_LowerIleum_cell|MOLECULE|Partition coefficient (intracellular/plasma)" id="761" />
-            <Map s="Organism|SmallIntestine|Volume (mucosa)" id="762" />
-            <Map s="FIRST_NEIGHBOR|..|Volume (mucosa)" id="763" />
-            <Map s="Organism|LargeIntestine|Volume (mucosa)" id="764" />
-            <Map s="..|P*SA interstitial -&gt; intracellular" id="765" />
-            <Map s="PA_liv" id="766" />
-            <Map s="FIRST_NEIGHBOR|..|..|PortalVein|Blood flow rate" id="767" />
-            <Map s="Q_pve" id="768" />
-            <Map s="Neighborhoods|Rectum_int_Rectum_cell|MOLECULE|Partition coefficient (intracellular/plasma)" id="769" />
-            <Map s="..|SalivaPlasmaRatio" id="770" />
-            <Map s="R" id="771" />
-            <Map s="SECOND_NEIGHBOR|pH (saliva)" id="772" />
-            <Map s="pH_slv" id="773" />
-            <Map s="Organism|pH (plasma)" id="774" />
-            <Map s="pH_PLS" id="775" />
-            <Map s="Organism|Lumen|Duodenum|Effective surface area enhancement factor" id="776" />
-            <Map s="Organism|Lumen|Duodenum|Geometric surface area" id="777" />
-            <Map s="Organism|Lumen|Duodenum|Microvilli factor" id="778" />
-            <Map s="MicrovilliFactor" id="779" />
-            <Map s="MOLECULE|Mucosa permeability scale factor (transcellular)" id="780" />
-            <Map s="P_int_scalefactor" id="781" />
-            <Map s="Organism|Lumen|UpperJejunum|Effective surface area enhancement factor" id="782" />
-            <Map s="Organism|Lumen|UpperJejunum|Geometric surface area" id="783" />
-            <Map s="Organism|Lumen|UpperJejunum|Microvilli factor" id="784" />
-            <Map s="Organism|Lumen|LowerJejunum|Effective surface area enhancement factor" id="785" />
-            <Map s="Organism|Lumen|LowerJejunum|Geometric surface area" id="786" />
-            <Map s="Organism|Lumen|LowerJejunum|Microvilli factor" id="787" />
-            <Map s="Organism|Lumen|UpperIleum|Effective surface area enhancement factor" id="788" />
-            <Map s="Organism|Lumen|UpperIleum|Geometric surface area" id="789" />
-            <Map s="Organism|Lumen|UpperIleum|Microvilli factor" id="790" />
-            <Map s="Organism|Lumen|LowerIleum|Effective surface area enhancement factor" id="791" />
-            <Map s="Organism|Lumen|LowerIleum|Geometric surface area" id="792" />
-            <Map s="Organism|Lumen|LowerIleum|Microvilli factor" id="793" />
-            <Map s="Organism|Lumen|Caecum|Effective surface area enhancement factor" id="794" />
-            <Map s="Organism|Lumen|Caecum|Geometric surface area" id="795" />
-            <Map s="Organism|Lumen|Caecum|Microvilli factor" id="796" />
-            <Map s="Organism|Lumen|ColonAscendens|Effective surface area enhancement factor" id="797" />
-            <Map s="Organism|Lumen|ColonAscendens|Geometric surface area" id="798" />
-            <Map s="Organism|Lumen|ColonAscendens|Microvilli factor" id="799" />
-            <Map s="Organism|Lumen|ColonTransversum|Effective surface area enhancement factor" id="800" />
-            <Map s="Organism|Lumen|ColonTransversum|Geometric surface area" id="801" />
-            <Map s="Organism|Lumen|ColonTransversum|Microvilli factor" id="802" />
-            <Map s="Organism|Lumen|ColonDescendens|Effective surface area enhancement factor" id="803" />
-            <Map s="Organism|Lumen|ColonDescendens|Geometric surface area" id="804" />
-            <Map s="Organism|Lumen|ColonDescendens|Microvilli factor" id="805" />
-            <Map s="Organism|Lumen|ColonSigmoid|Effective surface area enhancement factor" id="806" />
-            <Map s="Organism|Lumen|ColonSigmoid|Geometric surface area" id="807" />
-            <Map s="Organism|Lumen|ColonSigmoid|Microvilli factor" id="808" />
-            <Map s="Organism|Lumen|Rectum|Effective surface area enhancement factor" id="809" />
-            <Map s="Organism|Lumen|Rectum|Geometric surface area" id="810" />
-            <Map s="Organism|Lumen|Rectum|Microvilli factor" id="811" />
-            <Map s="Neighborhoods|Caecum_int_Caecum_cell|MOLECULE|Partition coefficient (intracellular/plasma)" id="812" />
-            <Map s="Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|MOLECULE|Partition coefficient (intracellular/plasma)" id="813" />
-            <Map s="Neighborhoods|ColonDescendens_int_ColonDescendens_cell|MOLECULE|Partition coefficient (intracellular/plasma)" id="814" />
-            <Map s="Neighborhoods|ColonTransversum_int_ColonTransversum_cell|MOLECULE|Partition coefficient (intracellular/plasma)" id="815" />
-            <Map s="Neighborhoods|ColonAscendens_int_ColonAscendens_cell|MOLECULE|Partition coefficient (intracellular/plasma)" id="816" />
-            <Map s="Neighborhoods|Duodenum_int_Duodenum_cell|MOLECULE|Partition coefficient (intracellular/plasma)" id="817" />
-            <Map s="Mean" id="818" />
-            <Map s="Deviation" id="819" />
-            <Map s="GeometricDeviation" id="820" />
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-            <Map s="Organism|Spleen|Vf (water)-WS" id="428" />
-            <Map s="Organism|Spleen|Vf (acidic phospholipids)-WS" id="429" />
-            <Map s="Organism|Spleen|Acidic phospholipids [mg/g] - RR" id="430" />
-            <Map s="Organism|Saliva|Density (tissue)" id="431" />
-            <Map s="Organism|Saliva|Saliva flow rate" id="432" />
-            <Map s="Organism|VenousBlood|Volume|Percentile" id="433" />
-            <Map s="Organism|VenousBlood|Volume|Mean" id="434" />
-            <Map s="Organism|VenousBlood|Volume|Deviation" id="435" />
-            <Map s="Organism|ArterialBlood|Volume|Percentile" id="436" />
-            <Map s="Organism|ArterialBlood|Volume|Mean" id="437" />
-            <Map s="Organism|ArterialBlood|Volume|Deviation" id="438" />
-            <Map s="Organism|Bone|Specific blood flow rate|Percentile" id="439" />
-            <Map s="Organism|Bone|Specific blood flow rate|Mean" id="440" />
-            <Map s="Organism|Bone|Specific blood flow rate|Deviation" id="441" />
-            <Map s="Organism|Bone|Volume|Percentile" id="442" />
-            <Map s="Organism|Bone|Volume|Mean" id="443" />
-            <Map s="Organism|Bone|Volume|Deviation" id="444" />
-            <Map s="Organism|Bone|Intracellular|pH" id="445" />
-            <Map s="Organism|Brain|Volume|Percentile" id="446" />
-            <Map s="Organism|Brain|Volume|Mean" id="447" />
-            <Map s="Organism|Brain|Volume|Deviation" id="448" />
-            <Map s="Organism|Brain|Specific blood flow rate|Percentile" id="449" />
-            <Map s="Organism|Brain|Specific blood flow rate|Mean" id="450" />
-            <Map s="Organism|Brain|Specific blood flow rate|Deviation" id="451" />
-            <Map s="Organism|Brain|Intracellular|pH" id="452" />
-            <Map s="Organism|Fat|Volume|Percentile" id="453" />
-            <Map s="Organism|Fat|Volume|Mean" id="454" />
-            <Map s="Organism|Fat|Volume|GeometricDeviation" id="455" />
-            <Map s="Organism|Fat|Vf (lipid)|Percentile" id="456" />
-            <Map s="Organism|Fat|Vf (lipid)|Mean" id="457" />
-            <Map s="Organism|Fat|Vf (neutral lipid)-PT|Percentile" id="458" />
-            <Map s="Organism|Fat|Vf (neutral lipid)-PT|Mean" id="459" />
-            <Map s="Organism|Fat|Vf (phospholipid)-PT|Percentile" id="460" />
-            <Map s="Organism|Fat|Vf (phospholipid)-PT|Mean" id="461" />
-            <Map s="Organism|Fat|Fraction interstitial|Percentile" id="462" />
-            <Map s="Organism|Fat|Fraction interstitial|Mean" id="463" />
-            <Map s="Organism|Fat|Vf (water)-PT|Percentile" id="464" />
-            <Map s="Organism|Fat|Vf (water)-PT|Mean" id="465" />
-            <Map s="Organism|Fat|Vf (water)|Percentile" id="466" />
-            <Map s="Organism|Fat|Vf (water)|Mean" id="467" />
-            <Map s="Organism|Fat|Vf (neutral lipid)-WS|Percentile" id="468" />
-            <Map s="Organism|Fat|Vf (neutral lipid)-WS|Mean" id="469" />
-            <Map s="Organism|Fat|Vf (neutral lipid)-RR|Percentile" id="470" />
-            <Map s="Organism|Fat|Vf (neutral lipid)-RR|Mean" id="471" />
-            <Map s="Organism|Fat|Vf (neutral phospholipid, plasma)-WS|Percentile" id="472" />
-            <Map s="Organism|Fat|Vf (neutral phospholipid, plasma)-WS|Mean" id="473" />
-            <Map s="Organism|Fat|Vf (neutral phospholipid)-RR|Percentile" id="474" />
-            <Map s="Organism|Fat|Vf (neutral phospholipid)-RR|Mean" id="475" />
-            <Map s="Organism|Fat|Vf (extracellular water)-RR|Percentile" id="476" />
-            <Map s="Organism|Fat|Vf (extracellular water)-RR|Mean" id="477" />
-            <Map s="Organism|Fat|Vf (intracellular water)-RR|Percentile" id="478" />
-            <Map s="Organism|Fat|Vf (intracellular water)-RR|Mean" id="479" />
-            <Map s="Organism|Fat|Vf (water)-WS|Percentile" id="480" />
-            <Map s="Organism|Fat|Vf (water)-WS|Mean" id="481" />
-            <Map s="Organism|Fat|Specific blood flow rate|Percentile" id="482" />
-            <Map s="Organism|Fat|Specific blood flow rate|Mean" id="483" />
-            <Map s="Organism|Fat|Specific blood flow rate|Deviation" id="484" />
-            <Map s="Organism|Fat|Intracellular|pH" id="485" />
-            <Map s="Organism|Gonads|Volume|Percentile" id="486" />
-            <Map s="Organism|Gonads|Volume|Mean" id="487" />
-            <Map s="Organism|Gonads|Volume|Deviation" id="488" />
-            <Map s="Organism|Gonads|Specific blood flow rate|Percentile" id="489" />
-            <Map s="Organism|Gonads|Specific blood flow rate|Mean" id="490" />
-            <Map s="Organism|Gonads|Specific blood flow rate|Deviation" id="491" />
-            <Map s="Organism|Gonads|Intracellular|pH" id="492" />
-            <Map s="Organism|Heart|Volume|Percentile" id="493" />
-            <Map s="Organism|Heart|Volume|Mean" id="494" />
-            <Map s="Organism|Heart|Volume|Deviation" id="495" />
-            <Map s="Organism|Heart|Specific blood flow rate|Percentile" id="496" />
-            <Map s="Organism|Heart|Specific blood flow rate|Mean" id="497" />
-            <Map s="Organism|Heart|Specific blood flow rate|Deviation" id="498" />
-            <Map s="Organism|Heart|Intracellular|pH" id="499" />
-            <Map s="Organism|Kidney|Volume|Percentile" id="500" />
-            <Map s="Organism|Kidney|Volume|Mean" id="501" />
-            <Map s="Organism|Kidney|Volume|Deviation" id="502" />
-            <Map s="Organism|Kidney|Hill coefficient for GFR|Percentile" id="503" />
-            <Map s="Organism|Kidney|Hill coefficient for GFR|Mean" id="504" />
-            <Map s="Organism|Kidney|Hill coefficient for GFR|Deviation" id="505" />
-            <Map s="Organism|Kidney|TM50 for GFR|Percentile" id="506" />
-            <Map s="Organism|Kidney|TM50 for GFR|Mean" id="507" />
-            <Map s="Organism|Kidney|TM50 for GFR|Deviation" id="508" />
-            <Map s="Organism|Kidney|GFRmat|Percentile" id="509" />
-            <Map s="Organism|Kidney|GFRmat|Mean" id="510" />
-            <Map s="Organism|Kidney|GFRmat|Deviation" id="511" />
-            <Map s="Organism|Kidney|Specific blood flow rate|Percentile" id="512" />
-            <Map s="Organism|Kidney|Specific blood flow rate|Mean" id="513" />
-            <Map s="Organism|Kidney|Specific blood flow rate|Deviation" id="514" />
-            <Map s="Organism|Kidney|Intracellular|pH" id="515" />
-            <Map s="Organism|Kidney|Urine|Volume" id="516" />
-            <Map s="Organism|Lumen|Stomach|Absorption of liquid" id="517" />
-            <Map s="Organism|Lumen|Stomach|GET of non-disintegrated moiety" id="518" />
-            <Map s="Organism|Lumen|Stomach|Inverse rate of inflow of liquid into stomach" id="519" />
-            <Map s="Organism|Lumen|Stomach|pH in fasted state" id="520" />
-            <Map s="Organism|Lumen|Stomach|Fractional steady state fill level" id="521" />
-            <Map s="Organism|Lumen|Stomach|Thickness of gut wall" id="522" />
-            <Map s="Organism|Lumen|Stomach|pH in fed state" id="523" />
-            <Map s="Organism|Lumen|Stomach|C1|Partition coefficient (water/container)" id="524" />
-            <Map s="Organism|Lumen|Duodenum|pH" id="525" />
-            <Map s="Organism|Lumen|Duodenum|Thickness_p3" id="526" />
-            <Map s="Organism|Lumen|Duodenum|Microvilli factor" id="527" />
-            <Map s="Organism|Lumen|Duodenum|Thickness_p1" id="528" />
-            <Map s="Organism|Lumen|Duodenum|r2_p1" id="529" />
-            <Map s="Organism|Lumen|Duodenum|r2_p0" id="530" />
-            <Map s="Organism|Lumen|Duodenum|r1_p1" id="531" />
-            <Map s="Organism|Lumen|Duodenum|r1_p0" id="532" />
-            <Map s="Organism|Lumen|Duodenum|L_p1" id="533" />
-            <Map s="Organism|Lumen|Duodenum|L_p0" id="534" />
-            <Map s="Organism|Lumen|Duodenum|Intestinal transit rate" id="535" />
-            <Map s="Organism|Lumen|Duodenum|Fractional steady state fill level" id="536" />
-            <Map s="Organism|Lumen|Duodenum|Thickness_p2" id="537" />
-            <Map s="Organism|Lumen|Duodenum|C1|Oral mass absorbed segment" id="538" />
-            <Map s="Organism|Lumen|Duodenum|C1|Partition coefficient (water/container)" id="539" />
-            <Map s="Organism|Lumen|UpperJejunum|pH" id="540" />
-            <Map s="Organism|Lumen|UpperJejunum|Thickness_p3" id="541" />
-            <Map s="Organism|Lumen|UpperJejunum|L_p1" id="542" />
-            <Map s="Organism|Lumen|UpperJejunum|r1_p1" id="543" />
-            <Map s="Organism|Lumen|UpperJejunum|r1_p0" id="544" />
-            <Map s="Organism|Lumen|UpperJejunum|L_p0" id="545" />
-            <Map s="Organism|Lumen|UpperJejunum|Intestinal transit rate" id="546" />
-            <Map s="Organism|Lumen|UpperJejunum|Fractional steady state fill level" id="547" />
-            <Map s="Organism|Lumen|UpperJejunum|Microvilli factor" id="548" />
-            <Map s="Organism|Lumen|UpperJejunum|Thickness_p2" id="549" />
-            <Map s="Organism|Lumen|UpperJejunum|Thickness_p1" id="550" />
-            <Map s="Organism|Lumen|UpperJejunum|r2_p1" id="551" />
-            <Map s="Organism|Lumen|UpperJejunum|r2_p0" id="552" />
-            <Map s="Organism|Lumen|UpperJejunum|C1|Partition coefficient (water/container)" id="553" />
-            <Map s="Organism|Lumen|UpperJejunum|C1|Oral mass absorbed segment" id="554" />
-            <Map s="Organism|Lumen|LowerJejunum|r1_p0" id="555" />
-            <Map s="Organism|Lumen|LowerJejunum|Thickness_p3" id="556" />
-            <Map s="Organism|Lumen|LowerJejunum|Thickness_p2" id="557" />
-            <Map s="Organism|Lumen|LowerJejunum|r2_p1" id="558" />
-            <Map s="Organism|Lumen|LowerJejunum|r2_p0" id="559" />
-            <Map s="Organism|Lumen|LowerJejunum|r1_p1" id="560" />
-            <Map s="Organism|Lumen|LowerJejunum|Microvilli factor" id="561" />
-            <Map s="Organism|Lumen|LowerJejunum|L_p1" id="562" />
-            <Map s="Organism|Lumen|LowerJejunum|L_p0" id="563" />
-            <Map s="Organism|Lumen|LowerJejunum|Intestinal transit rate" id="564" />
-            <Map s="Organism|Lumen|LowerJejunum|Fractional steady state fill level" id="565" />
-            <Map s="Organism|Lumen|LowerJejunum|Thickness_p1" id="566" />
-            <Map s="Organism|Lumen|LowerJejunum|pH" id="567" />
-            <Map s="Organism|Lumen|LowerJejunum|C1|Oral mass absorbed segment" id="568" />
-            <Map s="Organism|Lumen|LowerJejunum|C1|Partition coefficient (water/container)" id="569" />
-            <Map s="Organism|Lumen|UpperIleum|Thickness_p3" id="570" />
-            <Map s="Organism|Lumen|UpperIleum|Intestinal transit rate" id="571" />
-            <Map s="Organism|Lumen|UpperIleum|Thickness_p2" id="572" />
-            <Map s="Organism|Lumen|UpperIleum|Thickness_p1" id="573" />
-            <Map s="Organism|Lumen|UpperIleum|r2_p1" id="574" />
-            <Map s="Organism|Lumen|UpperIleum|r2_p0" id="575" />
-            <Map s="Organism|Lumen|UpperIleum|r1_p1" id="576" />
-            <Map s="Organism|Lumen|UpperIleum|r1_p0" id="577" />
-            <Map s="Organism|Lumen|UpperIleum|Fractional steady state fill level" id="578" />
-            <Map s="Organism|Lumen|UpperIleum|Microvilli factor" id="579" />
-            <Map s="Organism|Lumen|UpperIleum|L_p1" id="580" />
-            <Map s="Organism|Lumen|UpperIleum|L_p0" id="581" />
-            <Map s="Organism|Lumen|UpperIleum|pH" id="582" />
-            <Map s="Organism|Lumen|UpperIleum|C1|Partition coefficient (water/container)" id="583" />
-            <Map s="Organism|Lumen|UpperIleum|C1|Oral mass absorbed segment" id="584" />
-            <Map s="Organism|Lumen|LowerIleum|Fractional steady state fill level" id="585" />
-            <Map s="Organism|Lumen|LowerIleum|r1_p0" id="586" />
-            <Map s="Organism|Lumen|LowerIleum|Thickness_p3" id="587" />
-            <Map s="Organism|Lumen|LowerIleum|Thickness_p2" id="588" />
-            <Map s="Organism|Lumen|LowerIleum|Thickness_p1" id="589" />
-            <Map s="Organism|Lumen|LowerIleum|r2_p1" id="590" />
-            <Map s="Organism|Lumen|LowerIleum|r2_p0" id="591" />
-            <Map s="Organism|Lumen|LowerIleum|r1_p1" id="592" />
-            <Map s="Organism|Lumen|LowerIleum|pH" id="593" />
-            <Map s="Organism|Lumen|LowerIleum|Microvilli factor" id="594" />
-            <Map s="Organism|Lumen|LowerIleum|L_p1" id="595" />
-            <Map s="Organism|Lumen|LowerIleum|L_p0" id="596" />
-            <Map s="Organism|Lumen|LowerIleum|Intestinal transit rate" id="597" />
-            <Map s="Organism|Lumen|LowerIleum|C1|Oral mass absorbed segment" id="598" />
-            <Map s="Organism|Lumen|LowerIleum|C1|Partition coefficient (water/container)" id="599" />
-            <Map s="Organism|Lumen|Caecum|Fractional steady state fill level" id="600" />
-            <Map s="Organism|Lumen|Caecum|Thickness_p2" id="601" />
-            <Map s="Organism|Lumen|Caecum|Thickness_p1" id="602" />
-            <Map s="Organism|Lumen|Caecum|r2_p1" id="603" />
-            <Map s="Organism|Lumen|Caecum|r2_p0" id="604" />
-            <Map s="Organism|Lumen|Caecum|r1_p1" id="605" />
-            <Map s="Organism|Lumen|Caecum|r1_p0" id="606" />
-            <Map s="Organism|Lumen|Caecum|Microvilli factor" id="607" />
-            <Map s="Organism|Lumen|Caecum|L_p1" id="608" />
-            <Map s="Organism|Lumen|Caecum|L_p0" id="609" />
-            <Map s="Organism|Lumen|Caecum|Intestinal transit rate" id="610" />
-            <Map s="Organism|Lumen|Caecum|Thickness_p3" id="611" />
-            <Map s="Organism|Lumen|Caecum|pH" id="612" />
-            <Map s="Organism|Lumen|Caecum|C1|Oral mass absorbed segment" id="613" />
-            <Map s="Organism|Lumen|Caecum|C1|Partition coefficient (water/container)" id="614" />
-            <Map s="Organism|Lumen|ColonAscendens|Thickness_p3" id="615" />
-            <Map s="Organism|Lumen|ColonAscendens|Thickness_p2" id="616" />
-            <Map s="Organism|Lumen|ColonAscendens|Thickness_p1" id="617" />
-            <Map s="Organism|Lumen|ColonAscendens|r2_p0" id="618" />
-            <Map s="Organism|Lumen|ColonAscendens|r1_p1" id="619" />
-            <Map s="Organism|Lumen|ColonAscendens|r1_p0" id="620" />
-            <Map s="Organism|Lumen|ColonAscendens|pH" id="621" />
-            <Map s="Organism|Lumen|ColonAscendens|r2_p1" id="622" />
-            <Map s="Organism|Lumen|ColonAscendens|Microvilli factor" id="623" />
-            <Map s="Organism|Lumen|ColonAscendens|L_p1" id="624" />
-            <Map s="Organism|Lumen|ColonAscendens|L_p0" id="625" />
-            <Map s="Organism|Lumen|ColonAscendens|Intestinal transit rate" id="626" />
-            <Map s="Organism|Lumen|ColonAscendens|Fractional steady state fill level" id="627" />
-            <Map s="Organism|Lumen|ColonAscendens|C1|Oral mass absorbed segment" id="628" />
-            <Map s="Organism|Lumen|ColonAscendens|C1|Partition coefficient (water/container)" id="629" />
-            <Map s="Organism|Lumen|ColonTransversum|Fractional steady state fill level" id="630" />
-            <Map s="Organism|Lumen|ColonTransversum|L_p0" id="631" />
-            <Map s="Organism|Lumen|ColonTransversum|r2_p0" id="632" />
-            <Map s="Organism|Lumen|ColonTransversum|Thickness_p3" id="633" />
-            <Map s="Organism|Lumen|ColonTransversum|Thickness_p2" id="634" />
-            <Map s="Organism|Lumen|ColonTransversum|Thickness_p1" id="635" />
-            <Map s="Organism|Lumen|ColonTransversum|Intestinal transit rate" id="636" />
-            <Map s="Organism|Lumen|ColonTransversum|r2_p1" id="637" />
-            <Map s="Organism|Lumen|ColonTransversum|r1_p1" id="638" />
-            <Map s="Organism|Lumen|ColonTransversum|r1_p0" id="639" />
-            <Map s="Organism|Lumen|ColonTransversum|pH" id="640" />
-            <Map s="Organism|Lumen|ColonTransversum|Microvilli factor" id="641" />
-            <Map s="Organism|Lumen|ColonTransversum|L_p1" id="642" />
-            <Map s="Organism|Lumen|ColonTransversum|C1|Oral mass absorbed segment" id="643" />
-            <Map s="Organism|Lumen|ColonTransversum|C1|Partition coefficient (water/container)" id="644" />
-            <Map s="Organism|Lumen|ColonDescendens|r1_p0" id="645" />
-            <Map s="Organism|Lumen|ColonDescendens|r2_p1" id="646" />
-            <Map s="Organism|Lumen|ColonDescendens|r2_p0" id="647" />
-            <Map s="Organism|Lumen|ColonDescendens|pH" id="648" />
-            <Map s="Organism|Lumen|ColonDescendens|Microvilli factor" id="649" />
-            <Map s="Organism|Lumen|ColonDescendens|L_p1" id="650" />
-            <Map s="Organism|Lumen|ColonDescendens|L_p0" id="651" />
-            <Map s="Organism|Lumen|ColonDescendens|Intestinal transit rate" id="652" />
-            <Map s="Organism|Lumen|ColonDescendens|r1_p1" id="653" />
-            <Map s="Organism|Lumen|ColonDescendens|Thickness_p3" id="654" />
-            <Map s="Organism|Lumen|ColonDescendens|Thickness_p2" id="655" />
-            <Map s="Organism|Lumen|ColonDescendens|Thickness_p1" id="656" />
-            <Map s="Organism|Lumen|ColonDescendens|Fractional steady state fill level" id="657" />
-            <Map s="Organism|Lumen|ColonDescendens|C1|Oral mass absorbed segment" id="658" />
-            <Map s="Organism|Lumen|ColonDescendens|C1|Partition coefficient (water/container)" id="659" />
-            <Map s="Organism|Lumen|ColonSigmoid|r2_p0" id="660" />
-            <Map s="Organism|Lumen|ColonSigmoid|Thickness_p3" id="661" />
-            <Map s="Organism|Lumen|ColonSigmoid|Thickness_p2" id="662" />
-            <Map s="Organism|Lumen|ColonSigmoid|Thickness_p1" id="663" />
-            <Map s="Organism|Lumen|ColonSigmoid|Intestinal transit rate" id="664" />
-            <Map s="Organism|Lumen|ColonSigmoid|r1_p1" id="665" />
-            <Map s="Organism|Lumen|ColonSigmoid|r1_p0" id="666" />
-            <Map s="Organism|Lumen|ColonSigmoid|pH" id="667" />
-            <Map s="Organism|Lumen|ColonSigmoid|Microvilli factor" id="668" />
-            <Map s="Organism|Lumen|ColonSigmoid|L_p1" id="669" />
-            <Map s="Organism|Lumen|ColonSigmoid|r2_p1" id="670" />
-            <Map s="Organism|Lumen|ColonSigmoid|L_p0" id="671" />
-            <Map s="Organism|Lumen|ColonSigmoid|Fractional steady state fill level" id="672" />
-            <Map s="Organism|Lumen|ColonSigmoid|C1|Oral mass absorbed segment" id="673" />
-            <Map s="Organism|Lumen|ColonSigmoid|C1|Partition coefficient (water/container)" id="674" />
-            <Map s="Organism|Lumen|Rectum|Fractional steady state fill level" id="675" />
-            <Map s="Organism|Lumen|Rectum|Thickness_p2" id="676" />
-            <Map s="Organism|Lumen|Rectum|Thickness_p1" id="677" />
-            <Map s="Organism|Lumen|Rectum|r2_p1" id="678" />
-            <Map s="Organism|Lumen|Rectum|r2_p0" id="679" />
-            <Map s="Organism|Lumen|Rectum|r1_p1" id="680" />
-            <Map s="Organism|Lumen|Rectum|Intestinal transit rate" id="681" />
-            <Map s="Organism|Lumen|Rectum|L_p0" id="682" />
-            <Map s="Organism|Lumen|Rectum|pH" id="683" />
-            <Map s="Organism|Lumen|Rectum|Microvilli factor" id="684" />
-            <Map s="Organism|Lumen|Rectum|L_p1" id="685" />
-            <Map s="Organism|Lumen|Rectum|r1_p0" id="686" />
-            <Map s="Organism|Lumen|Rectum|Thickness_p3" id="687" />
-            <Map s="Organism|Lumen|Rectum|C1|Oral mass absorbed segment" id="688" />
-            <Map s="Organism|Lumen|Rectum|C1|Partition coefficient (water/container)" id="689" />
-            <Map s="Organism|Lumen|Feces|Liquid" id="690" />
-            <Map s="Organism|Lumen|Feces|Volume" id="691" />
-            <Map s="Organism|Lumen|Stomach|Length|Percentile" id="692" />
-            <Map s="Organism|Lumen|Stomach|Length|Mean" id="693" />
-            <Map s="Organism|Lumen|Stomach|GET_beta (Weibull function) variability factor|Percentile" id="694" />
-            <Map s="Organism|Lumen|Stomach|GET_beta (Weibull function) variability factor|Mean" id="695" />
-            <Map s="Organism|Lumen|Stomach|GET_beta (Weibull function) variability factor|GeometricDeviation" id="696" />
-            <Map s="Organism|Lumen|Stomach|GET_alpha (Weibull function) variability factor|Percentile" id="697" />
-            <Map s="Organism|Lumen|Stomach|GET_alpha (Weibull function) variability factor|Mean" id="698" />
-            <Map s="Organism|Lumen|Stomach|GET_alpha (Weibull function) variability factor|GeometricDeviation" id="699" />
-            <Map s="Organism|Lumen|Stomach|Gastric emptying time|Percentile" id="700" />
-            <Map s="Organism|Lumen|Stomach|Gastric emptying time|Mean" id="701" />
-            <Map s="Organism|Lumen|Stomach|Gastric emptying time|GeometricDeviation" id="702" />
-            <Map s="Organism|Lumen|Stomach|Distal radius|Percentile" id="703" />
-            <Map s="Organism|Lumen|Stomach|Distal radius|Mean" id="704" />
-            <Map s="Organism|Lumen|Stomach|Proximal radius|Percentile" id="705" />
-            <Map s="Organism|Lumen|Stomach|Proximal radius|Mean" id="706" />
-            <Map s="Organism|Lumen|Duodenum|Effective surface area enhancement factor|Percentile" id="707" />
-            <Map s="Organism|Lumen|Duodenum|Effective surface area enhancement factor|Mean" id="708" />
-            <Map s="Organism|Lumen|UpperJejunum|Effective surface area enhancement factor|Percentile" id="709" />
-            <Map s="Organism|Lumen|UpperJejunum|Effective surface area enhancement factor|Mean" id="710" />
-            <Map s="Organism|Lumen|LowerJejunum|Effective surface area enhancement factor|Percentile" id="711" />
-            <Map s="Organism|Lumen|LowerJejunum|Effective surface area enhancement factor|Mean" id="712" />
-            <Map s="Organism|Lumen|UpperIleum|Effective surface area enhancement factor|Percentile" id="713" />
-            <Map s="Organism|Lumen|UpperIleum|Effective surface area enhancement factor|Mean" id="714" />
-            <Map s="Organism|Lumen|LowerIleum|Effective surface area enhancement factor|Percentile" id="715" />
-            <Map s="Organism|Lumen|LowerIleum|Effective surface area enhancement factor|Mean" id="716" />
-            <Map s="Organism|Lumen|Caecum|Effective surface area enhancement factor|Percentile" id="717" />
-            <Map s="Organism|Lumen|Caecum|Effective surface area enhancement factor|Mean" id="718" />
-            <Map s="Organism|Lumen|ColonAscendens|Effective surface area enhancement factor|Percentile" id="719" />
-            <Map s="Organism|Lumen|ColonAscendens|Effective surface area enhancement factor|Mean" id="720" />
-            <Map s="Organism|Lumen|ColonTransversum|Effective surface area enhancement factor|Percentile" id="721" />
-            <Map s="Organism|Lumen|ColonTransversum|Effective surface area enhancement factor|Mean" id="722" />
-            <Map s="Organism|Lumen|ColonDescendens|Effective surface area enhancement factor|Percentile" id="723" />
-            <Map s="Organism|Lumen|ColonDescendens|Effective surface area enhancement factor|Mean" id="724" />
-            <Map s="Organism|Lumen|ColonSigmoid|Effective surface area enhancement factor|Percentile" id="725" />
-            <Map s="Organism|Lumen|ColonSigmoid|Effective surface area enhancement factor|Mean" id="726" />
-            <Map s="Organism|Lumen|Rectum|Effective surface area enhancement factor|Percentile" id="727" />
-            <Map s="Organism|Lumen|Rectum|Effective surface area enhancement factor|Mean" id="728" />
-            <Map s="Organism|Stomach|Volume|Percentile" id="729" />
-            <Map s="Organism|Stomach|Volume|Mean" id="730" />
-            <Map s="Organism|Stomach|Volume|Deviation" id="731" />
-            <Map s="Organism|Stomach|Specific blood flow rate|Percentile" id="732" />
-            <Map s="Organism|Stomach|Specific blood flow rate|Mean" id="733" />
-            <Map s="Organism|Stomach|Specific blood flow rate|Deviation" id="734" />
-            <Map s="Organism|Stomach|Intracellular|pH" id="735" />
-            <Map s="Organism|SmallIntestine|Small intestinal transit time|Percentile" id="736" />
-            <Map s="Organism|SmallIntestine|Small intestinal transit time|Mean" id="737" />
-            <Map s="Organism|SmallIntestine|Small intestinal transit time|GeometricDeviation" id="738" />
-            <Map s="Organism|SmallIntestine|Volume|Percentile" id="739" />
-            <Map s="Organism|SmallIntestine|Volume|Mean" id="740" />
-            <Map s="Organism|SmallIntestine|Volume|Deviation" id="741" />
-            <Map s="Organism|SmallIntestine|Specific blood flow rate|Percentile" id="742" />
-            <Map s="Organism|SmallIntestine|Specific blood flow rate|Mean" id="743" />
-            <Map s="Organism|SmallIntestine|Specific blood flow rate|Deviation" id="744" />
-            <Map s="Organism|SmallIntestine|Intracellular|pH" id="745" />
-            <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Density (tissue)" id="746" />
-            <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Fraction of blood for sampling" id="747" />
-            <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Fraction of regional blood flow rate" id="748" />
-            <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Fraction mucosa" id="749" />
-            <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Hydraulic conductivity" id="750" />
-            <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Radius (large pores)" id="751" />
-            <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Flow fraction via large pores" id="752" />
-            <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Radius (small pores)" id="753" />
-            <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Vf (lipid)" id="754" />
-            <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Vf (neutral lipid)-PT" id="755" />
-            <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Fraction vascular" id="756" />
-            <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Vf (phospholipid)-PT" id="757" />
-            <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Vf (protein)" id="758" />
-            <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Albumin ratio (tissue/plasma)" id="759" />
-            <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Lipoprotein ratio (tissue/plasma)" id="760" />
-            <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Albumin ratio (tissue/plasma)-PT" id="761" />
-            <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Vf (water)-PT" id="762" />
-            <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Vf (water)" id="763" />
-            <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Fraction interstitial" id="764" />
-            <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Vf (neutral lipid)-WS" id="765" />
-            <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Vf (neutral lipid)-RR" id="766" />
-            <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Vf (neutral phospholipid, plasma)-WS" id="767" />
-            <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Vf (neutral phospholipid)-RR" id="768" />
-            <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Vf (protein)-WS" id="769" />
-            <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Vf (extracellular water)-RR" id="770" />
-            <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Vf (intracellular water)-RR" id="771" />
-            <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Vf (water)-WS" id="772" />
-            <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Acidic phospholipids [mg/g] - RR" id="773" />
-            <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Vf (acidic phospholipids)-WS" id="774" />
-            <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Density (tissue)" id="775" />
-            <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Fraction of blood for sampling" id="776" />
-            <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Fraction mucosa" id="777" />
-            <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Fraction of regional blood flow rate" id="778" />
-            <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Hydraulic conductivity" id="779" />
-            <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Flow fraction via large pores" id="780" />
-            <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Radius (small pores)" id="781" />
-            <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Radius (large pores)" id="782" />
-            <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Vf (lipid)" id="783" />
-            <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Vf (neutral lipid)-PT" id="784" />
-            <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Fraction vascular" id="785" />
-            <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Vf (protein)" id="786" />
-            <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Vf (phospholipid)-PT" id="787" />
-            <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Vf (water)-PT" id="788" />
-            <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Lipoprotein ratio (tissue/plasma)" id="789" />
-            <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Albumin ratio (tissue/plasma)-PT" id="790" />
-            <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Vf (water)" id="791" />
-            <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Albumin ratio (tissue/plasma)" id="792" />
-            <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Fraction interstitial" id="793" />
-            <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Vf (neutral lipid)-RR" id="794" />
-            <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Vf (neutral lipid)-WS" id="795" />
-            <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Vf (neutral phospholipid, plasma)-WS" id="796" />
-            <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Vf (neutral phospholipid)-RR" id="797" />
-            <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Vf (protein)-WS" id="798" />
-            <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Vf (extracellular water)-RR" id="799" />
-            <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Vf (water)-WS" id="800" />
-            <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Vf (intracellular water)-RR" id="801" />
-            <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Acidic phospholipids [mg/g] - RR" id="802" />
-            <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Vf (acidic phospholipids)-WS" id="803" />
-            <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Density (tissue)" id="804" />
-            <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Fraction of blood for sampling" id="805" />
-            <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Fraction of regional blood flow rate" id="806" />
-            <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Fraction mucosa" id="807" />
-            <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Radius (small pores)" id="808" />
-            <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Flow fraction via large pores" id="809" />
-            <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Hydraulic conductivity" id="810" />
-            <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Radius (large pores)" id="811" />
-            <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Vf (neutral lipid)-PT" id="812" />
-            <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Vf (lipid)" id="813" />
-            <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Fraction vascular" id="814" />
-            <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Vf (phospholipid)-PT" id="815" />
-            <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Vf (protein)" id="816" />
-            <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Albumin ratio (tissue/plasma)" id="817" />
-            <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Lipoprotein ratio (tissue/plasma)" id="818" />
-            <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Albumin ratio (tissue/plasma)-PT" id="819" />
-            <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Vf (water)" id="820" />
-            <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Vf (water)-PT" id="821" />
-            <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Fraction interstitial" id="822" />
-            <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Vf (neutral lipid)-WS" id="823" />
-            <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Vf (neutral lipid)-RR" id="824" />
-            <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Vf (neutral phospholipid, plasma)-WS" id="825" />
-            <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Vf (neutral phospholipid)-RR" id="826" />
-            <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Vf (extracellular water)-RR" id="827" />
-            <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Vf (protein)-WS" id="828" />
-            <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Vf (intracellular water)-RR" id="829" />
-            <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Vf (water)-WS" id="830" />
-            <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Vf (acidic phospholipids)-WS" id="831" />
-            <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Acidic phospholipids [mg/g] - RR" id="832" />
-            <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Density (tissue)" id="833" />
-            <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Fraction of blood for sampling" id="834" />
-            <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Fraction mucosa" id="835" />
-            <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Fraction of regional blood flow rate" id="836" />
-            <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Radius (large pores)" id="837" />
-            <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Hydraulic conductivity" id="838" />
-            <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Flow fraction via large pores" id="839" />
-            <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Radius (small pores)" id="840" />
-            <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Vf (lipid)" id="841" />
-            <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Vf (neutral lipid)-PT" id="842" />
-            <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Fraction vascular" id="843" />
-            <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Vf (protein)" id="844" />
-            <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Vf (phospholipid)-PT" id="845" />
-            <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Vf (water)" id="846" />
-            <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Albumin ratio (tissue/plasma)" id="847" />
-            <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Lipoprotein ratio (tissue/plasma)" id="848" />
-            <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Albumin ratio (tissue/plasma)-PT" id="849" />
-            <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Vf (water)-PT" id="850" />
-            <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Fraction interstitial" id="851" />
-            <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Vf (neutral lipid)-WS" id="852" />
-            <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Vf (neutral lipid)-RR" id="853" />
-            <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Vf (neutral phospholipid)-RR" id="854" />
-            <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Vf (neutral phospholipid, plasma)-WS" id="855" />
-            <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Vf (extracellular water)-RR" id="856" />
-            <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Vf (protein)-WS" id="857" />
-            <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Vf (water)-WS" id="858" />
-            <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Vf (intracellular water)-RR" id="859" />
-            <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Vf (acidic phospholipids)-WS" id="860" />
-            <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Acidic phospholipids [mg/g] - RR" id="861" />
-            <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Density (tissue)" id="862" />
-            <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Fraction of blood for sampling" id="863" />
-            <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Fraction mucosa" id="864" />
-            <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Fraction of regional blood flow rate" id="865" />
-            <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Flow fraction via large pores" id="866" />
-            <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Radius (small pores)" id="867" />
-            <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Hydraulic conductivity" id="868" />
-            <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Radius (large pores)" id="869" />
-            <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Vf (neutral lipid)-PT" id="870" />
-            <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Vf (lipid)" id="871" />
-            <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Fraction vascular" id="872" />
-            <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Vf (phospholipid)-PT" id="873" />
-            <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Vf (protein)" id="874" />
-            <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Albumin ratio (tissue/plasma)" id="875" />
-            <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Lipoprotein ratio (tissue/plasma)" id="876" />
-            <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Albumin ratio (tissue/plasma)-PT" id="877" />
-            <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Vf (water)-PT" id="878" />
-            <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Vf (water)" id="879" />
-            <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Fraction interstitial" id="880" />
-            <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Vf (neutral lipid)-WS" id="881" />
-            <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Vf (neutral lipid)-RR" id="882" />
-            <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Vf (neutral phospholipid)-RR" id="883" />
-            <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Vf (neutral phospholipid, plasma)-WS" id="884" />
-            <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Vf (protein)-WS" id="885" />
-            <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Vf (extracellular water)-RR" id="886" />
-            <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Vf (intracellular water)-RR" id="887" />
-            <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Vf (water)-WS" id="888" />
-            <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Vf (acidic phospholipids)-WS" id="889" />
-            <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Acidic phospholipids [mg/g] - RR" id="890" />
-            <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|pH" id="891" />
-            <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|pH" id="892" />
-            <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|pH" id="893" />
-            <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|pH" id="894" />
-            <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|pH" id="895" />
-            <Map s="Organism|LargeIntestine|Large intestinal transit time|Percentile" id="896" />
-            <Map s="Organism|LargeIntestine|Large intestinal transit time|Mean" id="897" />
-            <Map s="Organism|LargeIntestine|Volume|Percentile" id="898" />
-            <Map s="Organism|LargeIntestine|Volume|Mean" id="899" />
-            <Map s="Organism|LargeIntestine|Volume|Deviation" id="900" />
-            <Map s="Organism|LargeIntestine|Specific blood flow rate|Percentile" id="901" />
-            <Map s="Organism|LargeIntestine|Specific blood flow rate|Mean" id="902" />
-            <Map s="Organism|LargeIntestine|Specific blood flow rate|Deviation" id="903" />
-            <Map s="Organism|LargeIntestine|Intracellular|pH" id="904" />
-            <Map s="Organism|LargeIntestine|Mucosa|Caecum|Density (tissue)" id="905" />
-            <Map s="Organism|LargeIntestine|Mucosa|Caecum|Fraction of blood for sampling" id="906" />
-            <Map s="Organism|LargeIntestine|Mucosa|Caecum|Fraction of regional blood flow rate" id="907" />
-            <Map s="Organism|LargeIntestine|Mucosa|Caecum|Fraction mucosa" id="908" />
-            <Map s="Organism|LargeIntestine|Mucosa|Caecum|Radius (small pores)" id="909" />
-            <Map s="Organism|LargeIntestine|Mucosa|Caecum|Flow fraction via large pores" id="910" />
-            <Map s="Organism|LargeIntestine|Mucosa|Caecum|Radius (large pores)" id="911" />
-            <Map s="Organism|LargeIntestine|Mucosa|Caecum|Hydraulic conductivity" id="912" />
-            <Map s="Organism|LargeIntestine|Mucosa|Caecum|Vf (neutral lipid)-PT" id="913" />
-            <Map s="Organism|LargeIntestine|Mucosa|Caecum|Vf (lipid)" id="914" />
-            <Map s="Organism|LargeIntestine|Mucosa|Caecum|Fraction vascular" id="915" />
-            <Map s="Organism|LargeIntestine|Mucosa|Caecum|Vf (protein)" id="916" />
-            <Map s="Organism|LargeIntestine|Mucosa|Caecum|Vf (phospholipid)-PT" id="917" />
-            <Map s="Organism|LargeIntestine|Mucosa|Caecum|Vf (water)-PT" id="918" />
-            <Map s="Organism|LargeIntestine|Mucosa|Caecum|Lipoprotein ratio (tissue/plasma)" id="919" />
-            <Map s="Organism|LargeIntestine|Mucosa|Caecum|Vf (water)" id="920" />
-            <Map s="Organism|LargeIntestine|Mucosa|Caecum|Albumin ratio (tissue/plasma)" id="921" />
-            <Map s="Organism|LargeIntestine|Mucosa|Caecum|Albumin ratio (tissue/plasma)-PT" id="922" />
-            <Map s="Organism|LargeIntestine|Mucosa|Caecum|Fraction interstitial" id="923" />
-            <Map s="Organism|LargeIntestine|Mucosa|Caecum|Vf (neutral lipid)-WS" id="924" />
-            <Map s="Organism|LargeIntestine|Mucosa|Caecum|Vf (neutral lipid)-RR" id="925" />
-            <Map s="Organism|LargeIntestine|Mucosa|Caecum|Vf (neutral phospholipid)-RR" id="926" />
-            <Map s="Organism|LargeIntestine|Mucosa|Caecum|Vf (neutral phospholipid, plasma)-WS" id="927" />
-            <Map s="Organism|LargeIntestine|Mucosa|Caecum|Vf (extracellular water)-RR" id="928" />
-            <Map s="Organism|LargeIntestine|Mucosa|Caecum|Vf (protein)-WS" id="929" />
-            <Map s="Organism|LargeIntestine|Mucosa|Caecum|Vf (intracellular water)-RR" id="930" />
-            <Map s="Organism|LargeIntestine|Mucosa|Caecum|Vf (water)-WS" id="931" />
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-            <Map s="Organism|LargeIntestine|Mucosa|Rectum|Vf (lipid)" id="1058" />
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-            <Map s="Organism|LargeIntestine|Mucosa|Rectum|Acidic phospholipids [mg/g] - RR" id="1078" />
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-            <Map s="Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|pH" id="1080" />
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-            <Map s="Organism|LargeIntestine|Mucosa|Rectum|Intracellular|pH" id="1084" />
-            <Map s="Organism|Liver|Volume|Percentile" id="1085" />
-            <Map s="Organism|Liver|Volume|Mean" id="1086" />
-            <Map s="Organism|Liver|Volume|Deviation" id="1087" />
-            <Map s="Organism|Liver|Specific blood flow rate|Percentile" id="1088" />
-            <Map s="Organism|Liver|Specific blood flow rate|Mean" id="1089" />
-            <Map s="Organism|Liver|Specific blood flow rate|Deviation" id="1090" />
-            <Map s="Organism|Liver|Intracellular|pH" id="1091" />
-            <Map s="Organism|Lung|Volume|Percentile" id="1092" />
-            <Map s="Organism|Lung|Volume|Mean" id="1093" />
-            <Map s="Organism|Lung|Volume|GeometricDeviation" id="1094" />
-            <Map s="Organism|Lung|Fraction vascular|Percentile" id="1095" />
-            <Map s="Organism|Lung|Fraction vascular|Mean" id="1096" />
-            <Map s="Organism|Lung|Intracellular|pH" id="1097" />
-            <Map s="Organism|Muscle|Volume|Percentile" id="1098" />
-            <Map s="Organism|Muscle|Volume|Mean" id="1099" />
-            <Map s="Organism|Muscle|Volume|GeometricDeviation" id="1100" />
-            <Map s="Organism|Muscle|Vf (lipid)|Percentile" id="1101" />
-            <Map s="Organism|Muscle|Vf (lipid)|Mean" id="1102" />
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-            <Map s="Organism|Muscle|Vf (protein)|Percentile" id="1107" />
-            <Map s="Organism|Muscle|Vf (protein)|Mean" id="1108" />
-            <Map s="Organism|Muscle|Fraction interstitial|Percentile" id="1109" />
-            <Map s="Organism|Muscle|Fraction interstitial|Mean" id="1110" />
-            <Map s="Organism|Muscle|Vf (water)-PT|Percentile" id="1111" />
-            <Map s="Organism|Muscle|Vf (water)-PT|Mean" id="1112" />
-            <Map s="Organism|Muscle|Vf (water)|Percentile" id="1113" />
-            <Map s="Organism|Muscle|Vf (water)|Mean" id="1114" />
-            <Map s="Organism|Muscle|Vf (neutral lipid)-RR|Percentile" id="1115" />
-            <Map s="Organism|Muscle|Vf (neutral lipid)-RR|Mean" id="1116" />
-            <Map s="Organism|Muscle|Vf (neutral lipid)-WS|Percentile" id="1117" />
-            <Map s="Organism|Muscle|Vf (neutral lipid)-WS|Mean" id="1118" />
-            <Map s="Organism|Muscle|Vf (neutral phospholipid)-RR|Percentile" id="1119" />
-            <Map s="Organism|Muscle|Vf (neutral phospholipid)-RR|Mean" id="1120" />
-            <Map s="Organism|Muscle|Vf (neutral phospholipid, plasma)-WS|Percentile" id="1121" />
-            <Map s="Organism|Muscle|Vf (neutral phospholipid, plasma)-WS|Mean" id="1122" />
-            <Map s="Organism|Muscle|Vf (extracellular water)-RR|Percentile" id="1123" />
-            <Map s="Organism|Muscle|Vf (extracellular water)-RR|Mean" id="1124" />
-            <Map s="Organism|Muscle|Vf (protein)-WS|Percentile" id="1125" />
-            <Map s="Organism|Muscle|Vf (protein)-WS|Mean" id="1126" />
-            <Map s="Organism|Muscle|Vf (intracellular water)-RR|Percentile" id="1127" />
-            <Map s="Organism|Muscle|Vf (intracellular water)-RR|Mean" id="1128" />
-            <Map s="Organism|Muscle|Vf (water)-WS|Percentile" id="1129" />
-            <Map s="Organism|Muscle|Vf (water)-WS|Mean" id="1130" />
-            <Map s="Organism|Muscle|Specific blood flow rate|Percentile" id="1131" />
-            <Map s="Organism|Muscle|Specific blood flow rate|Mean" id="1132" />
-            <Map s="Organism|Muscle|Specific blood flow rate|Deviation" id="1133" />
-            <Map s="Organism|Muscle|Intracellular|pH" id="1134" />
-            <Map s="Organism|Pancreas|Volume|Percentile" id="1135" />
-            <Map s="Organism|Pancreas|Volume|Mean" id="1136" />
-            <Map s="Organism|Pancreas|Volume|Deviation" id="1137" />
-            <Map s="Organism|Pancreas|Specific blood flow rate|Percentile" id="1138" />
-            <Map s="Organism|Pancreas|Specific blood flow rate|Mean" id="1139" />
-            <Map s="Organism|Pancreas|Specific blood flow rate|Deviation" id="1140" />
-            <Map s="Organism|Pancreas|Intracellular|pH" id="1141" />
-            <Map s="Organism|PortalVein|Volume|Percentile" id="1142" />
-            <Map s="Organism|PortalVein|Volume|Mean" id="1143" />
-            <Map s="Organism|PortalVein|Volume|Deviation" id="1144" />
-            <Map s="Organism|Skin|Volume|Percentile" id="1145" />
-            <Map s="Organism|Skin|Volume|Mean" id="1146" />
-            <Map s="Organism|Skin|Volume|Deviation" id="1147" />
-            <Map s="Organism|Skin|Specific blood flow rate|Percentile" id="1148" />
-            <Map s="Organism|Skin|Specific blood flow rate|Mean" id="1149" />
-            <Map s="Organism|Skin|Specific blood flow rate|Deviation" id="1150" />
-            <Map s="Organism|Skin|Intracellular|pH" id="1151" />
-            <Map s="Organism|Spleen|Volume|Percentile" id="1152" />
-            <Map s="Organism|Spleen|Volume|Mean" id="1153" />
-            <Map s="Organism|Spleen|Volume|GeometricDeviation" id="1154" />
-            <Map s="Organism|Spleen|Specific blood flow rate|Percentile" id="1155" />
-            <Map s="Organism|Spleen|Specific blood flow rate|Mean" id="1156" />
-            <Map s="Organism|Spleen|Specific blood flow rate|Deviation" id="1157" />
-            <Map s="Organism|Spleen|Intracellular|pH" id="1158" />
-            <Map s="Organism|Saliva|Saliva|pH (saliva)" id="1159" />
-            <Map s="Organism|SA proportionality factor" id="1160" />
-            <Map s="Organism|Surface area scaling exponent" id="1161" />
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-              <Parameter id="ABEeDJJlyUGd_E_r_YosDg" name="Volume (plasma)" description="Whole body plasma volume" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="t8Cs26aQRUy_kEVOA3nTkQ" visible="0" canBeVaried="0" displayUnit="l" />
-              <Parameter id="w9GYFlv4YkWWaWMIUpFv4Q" name="Surface area scaling exponent" description="Global shape parameter; used (as exponent) for calculating diffusion stream between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-              <Parameter id="4twvzuwuEUCpVU2IAwR5Rw" name="Weight" description="Body weight" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="5NfeZWwmw0GljuJMF9i5Xg" visible="1" canBeVaried="1" displayUnit="kg" />
-              <Parameter id="Akedi9owJ0e7BQmUOrObog" name="Estimated gestational age" description="Estimated gestational age" persistable="0" isFixedValue="0" dim="Age in weeks" quantityType="Parameter" formula="CckOeL5hIk6w2FqbJnQpzA" visible="0" canBeVaried="1" displayUnit="week(s)" />
-              <Parameter id="Qvc3WWn55UGkICllorWOcQ" name="BMI" description="Body mass index" persistable="0" isFixedValue="0" dim="BMI" quantityType="Parameter" formula="vERT48h6FkqUlnkWGPKRBA" visible="1" canBeVaried="1" displayUnit="kg/m²" />
-              <Parameter id="m6RDZ3-qsEapYq-Fq3oEGA" name="Vf (neutral lipid, blood cells)-WS" description="Fractional volume content of neutral lipid in blood cells used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.003" />
-              <Parameter id="zLube9RpAUyhAG5InheVHw" name="Vf (water,plasma)" description="Fractional volume content of water in plasma used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.926" />
-              <Parameter id="wi2CwUl0WUWfgdtghgc-Uw" name="Vf (water,interstitial)" description="Fractional volume content of water in interstitial space used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.935" />
-              <Parameter id="AkxlzEjXJUquK6RkSN0i_g" name="Vf (water,blood cells)" description="Fractional volume content of water in blood cells used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.625" />
-              <Parameter id="9x4jwzhnz0mMqo_8ZPGKtA" name="Vf (protein,plasma)" description="Fractional volume content of protein in plasma used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.067" />
-              <Parameter id="r0ew8eBzo0ukwJGYaugRVg" name="Vf (protein,blood cells)" description="Fractional volume content of protein in blood cells used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.325" />
-              <Parameter id="FWduD_gQlUG3AaCwHgJaTg" name="Protein ratio (interstial/plasma)" description="The ratio between the protein volume fraction in interstitial space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.37" />
-              <Parameter id="SZZ5Invm6EKaZgZsoGf6OQ" name="Vf (lipid, blood cells)" description="Fractional volume content of lipid in blood cells" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.005" />
-              <Parameter id="Eqxn_rbNz0efs5abnUFxzQ" name="Vf (lipid, plasma)" description="Fractional volume content of lipid in plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.007" />
-              <Parameter id="P-1iTDzEU0e512ILMD-MFg" name="Vf (neutral lipid, plasma)-RR" description="Fractional volume content of neutral lipid in plasma used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0032" />
-              <Parameter id="mxCkp1xy6kSseKkOitohAg" name="Thickness (endothelium)" description="Thickness of vascular endothelium" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="3E-06" displayUnit="cm" />
-              <Parameter id="2IIUDdU890avKzBYZFa0hA" name="pH (plasma)" description="pH of plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.4" />
-              <Parameter id="zZ8SDmlBs0ufvPyJv6oIGA" name="pH (blood cells)" description="Intracellular pH of blood cells" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.22" />
-              <Parameter id="bOWjAb1T906rm-GHo6SetQ" name="pH (interstitial)" description="pH of interstitial space" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.4" />
-              <Parameter id="ydTn5OhivEudtDGDovYD1g" name="pH (intracellular)" description="pH of intracellular space" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7" />
-              <Parameter id="SYVETSLh-0O7Jll-iRlwdQ" name="R*T" description="Gas constant-body temperature product (37°C)" persistable="0" isFixedValue="0" dim="RT" quantityType="Parameter" visible="1" canBeVaried="0" value="928.8" displayUnit="N*cm/mol" />
-              <Parameter id="cb1ckdy5wUSpI5TgBFU6yQ" name="Na" description="Avogadro constant" persistable="0" isFixedValue="0" dim="Inversed mol" quantityType="Parameter" visible="0" canBeVaried="0" value="6.022E+17" displayUnit="1/mol" />
-              <Parameter id="IDZlPad8AkmFrLrL_5L0Pg" name="Gestational age" description="Gestational age" persistable="0" isFixedValue="0" dim="Age in weeks" quantityType="Parameter" visible="1" canBeVaried="1" value="40" displayUnit="week(s)" />
-              <Parameter id="7e_jYxnF50yw0yefyy0sbA" name="Age" description="Age" persistable="0" isFixedValue="0" dim="Age in years" quantityType="Parameter" visible="1" canBeVaried="1" value="30" displayUnit="year(s)" />
-              <Parameter id="MEDVxCY72EmkQ8boKcBubg" name="Fraction endosomal (global)" description="Fraction of endosomal space in vascular endothelium" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" visible="1" canBeVaried="1" value="0.2" />
-              <Parameter id="jqsPwTPS1EmXMfZOyPpiTw" name="Vf (neutral lipid, plasma)-PT" description="Fractional volume content of neutral lipid in plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0035" />
-              <Parameter id="t1zO4BLgNkq_h3PSNazJTg" name="Vf (neutral phospholipid, blood cells)-WS" description="Fractional volume content of neutral phospholipid in blood cells used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0059" />
-              <Parameter id="zWvREZ5dpES00eKl2upI3w" name="Vf (neutral phospholipid, plasma)-RR" description="Fractional volume content of neutral phospholipid in plasma used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0021" />
-              <Parameter id="FTVVgKvPNE23JIFLQTTi7w" name="Surface/Volume ratio (blood cells)" description="Surface area to volume ratio of blood cells" persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" visible="0" canBeVaried="1" value="167000" displayUnit="1/cm" />
-              <Parameter id="QqwoG6640EWSAxegwWgFrg" name="Vf (phospholipid, plasma)-PT" description="Fractional volume content of phospholipid in plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.00225" />
-              <Parameter id="zqqpbJq5RkOEZYbfxdtZNQ" name="Vf (acidic phospholipids, blood cells)-WS" description="Fractional volume content of acidic phospholipid in blood cells used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.001" />
-              <Parameter id="cU1_ZLpSAUe7AMa33iP9wQ" name="Vf (neutral lipid, blood cells)-RR" description="Fractional volume content of neutral lipid in blood cells used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0012" />
-              <Parameter id="6O0xJczfqU2wHZx8PEZi9g" name="Plasma protein scale factor" description="Scale factor for the fraction unbound in plasma. This factor can be used if changes in the plasma protein concentration and, as a result, in the plasma protein binding of the drug are expected due to e.g. ageing or certain diseases such as cirrhosis, sepsis, or renal failure" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="1" />
-              <Parameter id="ruPSHmt1j0iXpKHdvxo1vw" name="Fraction of endosomal uptake from plasma (global)" description="Fraction of drug uptake from plasma into endosomal space relative to total uptake from plasma and interstitial space" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-              <Parameter id="Lnzti5Jxdkq4Fj02hDGmeA" name="Ontogeny factor (alpha1-acid glycoprotein)" description="Ontogeny factor (α1-acid glycoprotein)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-              <Parameter id="dBJxYoeiUEKQ1v3s4-eI0Q" name="Ontogeny factor (albumin)" description="Ontogeny factor (albumin)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-              <Parameter id="AomGEEKMTk2tzhzBJxjm4A" name="Height" description="Body height" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="16.996" displayUnit="cm" />
-              <Parameter id="KsYSbKAlu0iDu0NWc1lx2Q" name="Vf (neutral phospholipid, blood cells)-RR" description="Fractional volume content of neutral phospholipid in blood cells used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0033" />
-              <Parameter id="eoHYeZl2Gke2i_2QxvSEAA" name="Vf (water,plasma)-PT" description="Fractional volume content of water in plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.945" />
-              <Parameter id="CpgL_qFWU0OL_dSmkRHkJQ" name="Acidic phospholipids (blood cells) [mg/g] - RR" description="Concentration of acidic phospholipids in red blood cells [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.57" />
-              <Parameter id="TF2UUOC9CkOMCztlYJhSsg" name="Fraction recycled to plasma (global)" description="Fraction of drug recycling to plasma relative to total recycling to plasma and interstitial space" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-              <Parameter id="8kVQvY_pKUmNpt_JBRRMXA" name="Vf (intracellular water, blood cells)-RR" description="Fractional volume content of intracellular water in blood cells used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.63" />
-              <Parameter id="q9pgUdHjLEWCzhjRfdioIw" name="Rate constant for endosomal uptake (global)" description="Rate constant for endosomal uptake for all organs" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" visible="1" canBeVaried="1" value="0.36" displayUnit="1/min" />
-              <Parameter id="_iC06AJAtUqKjxbhADtEFA" name="Rate constant for recycling from endosomal space (global)" description="Rate constant for recycling from endosomal space for all organs" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" visible="1" canBeVaried="1" value="0.083" displayUnit="1/min" />
-              <DistributedParameter id="yXG6xBQRk0CGLBtApbvxAQ" name="Hematocrit" description="Hematocrit" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="zVlcxA1tz0qpGRMB2puRdw" mode="Logical" visible="1">
-                <Children>
-                  <Parameter id="t4tX2ZpGmE6PDqUNMXv0GQ" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                  <Parameter id="zXB_tDHJ_k-H6-BVF14h7w" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.47" />
-                </Children>
-              </DistributedParameter>
-              <DistributedParameter id="rNO8CtwwBkmztzzNuJryyA" name="MeanBW" description="Weight" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="cq6wpMJuDkygXmj8eKHVlA" mode="Logical" visible="0" displayUnit="kg">
-                <Children>
-                  <Parameter id="EBUkP2qzukSmorqpLDzwNA" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" displayUnit="kg" />
-                  <Parameter id="l1f6xadDTEWL1w9uwHr9OQ" name="Mean" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" visible="0" canBeVaried="1" value="60.034" displayUnit="kg" />
-                  <Parameter id="gGx5Emp0CUiB6NFZhEBBlw" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" visible="0" canBeVaried="1" value="3.0017" displayUnit="kg" />
-                </Children>
-              </DistributedParameter>
-              <DistributedParameter id="zdD3Byo5uEqnh-cUvwqJ8g" name="MeanHeight" description="Height" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Qlb0a7jM60mg0lWabVrflw" mode="Logical" visible="0" displayUnit="cm">
-                <Children>
-                  <Parameter id="aDVft0wucE6P4SSBB6xoiw" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" displayUnit="cm" />
-                  <Parameter id="-rYdRopSk0G8zYftVgD_hg" name="Mean" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="16.996" displayUnit="cm" />
-                  <Parameter id="0NSkmgnHHE2HkVOfk9E0jg" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.59486" displayUnit="cm" />
-                </Children>
-              </DistributedParameter>
-              <Container id="uAdUCVBBYUS3299aaPW3gg" name="PeripheralVenousBlood" description="Peripheral Venous Blood" icon="VenousBlood" mode="Logical" containerType="Organ">
-                <Children>
-                  <Container id="cTUAkJl7s0CVElr-8d0lPQ" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Observer id="8iRjFSeZD0iH6_RD8YyXxA" name="Blood Cells" description="Blood Cells" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="BsdRILXOJEi3B9i7jlk4nA" displayUnit="µmol/l" />
-                      <Observer id="LQKnRD3x2ESzfrZGy3OF4w" name="Plasma (Peripheral Venous Blood)" description="Plasma" persistable="1" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="Ij1MCjGQykmVi70pU6OOhA" displayUnit="µmol/l" />
-                      <Observer id="0FSVs6yg5k2bnXKd-gfUqg" name="Plasma Unbound (Peripheral Venous Blood)" description="Plasma Unbound" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="3vxW0wxpG0ivBd-ifK86ZQ" displayUnit="µmol/l" />
-                      <Observer id="KqggQ3SI-EWT11mVD_iomw" name="Whole Blood (Peripheral Venous Blood)" description="Whole Blood" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="3Le0qdHJZUCGNRv0a1ic3A" displayUnit="µmol/l" />
-                    </Children>
-                  </Container>
-                </Children>
-              </Container>
-              <Container id="nMPjSz4Fkk6bNFLBHJyh6g" name="VenousBlood" description="VenousBlood" icon="VenousBlood" mode="Logical" containerType="Organ">
-                <Tags>
-                  <Tag value="BloodOrgan" />
-                </Tags>
-                <Children>
-                  <Parameter id="5V1YiE1NoECQyFUoNMV1QQ" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="uSjt8LuoBUu75Z4-7ZUOCw" visible="0" canBeVaried="1" displayUnit="kg" />
-                  <Parameter id="Nbktz9Qh7kaQ0jqrrjP9Bg" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                  <Parameter id="aJ5FLg9mCUy7uhjvi3xL4A" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="0" value="0.75" />
-                  <Parameter id="Qx5VxTih6kmUw090GAcSRw" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="1" />
-                  <DistributedParameter id="HVx1rqsQX0qdioAS85mddA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="j9Y1O-XvkEWhRHVXNDELaQ" mode="Logical" visible="1" displayUnit="l">
-                    <Children>
-                      <Parameter id="aFhvXcSb30aaCYN9BSCMWw" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.501140854040494" displayUnit="l" />
-                      <Parameter id="m2JR5LWh1UeavI1eq8JmIg" name="Mean" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" value="0.776531873" displayUnit="l" />
-                      <Parameter id="E4UmoxpUsESkYr-uXjXYAw" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" value="0.038826594" displayUnit="l" />
-                    </Children>
-                  </DistributedParameter>
-                  <Container id="J2AzZMiPQUibGWyUqz4XLA" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="BloodOrgan" />
-                      <Tag value="VenousBlood" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="5Hhhe_mTC0quX-4Wq4tjoQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="PnEwytfbw0yZn_t7q9ukhw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="InNrdVCgRUCPod7Jj5RRRw" visible="1" canBeVaried="1" displayUnit="l" />
-                      <MoleculeAmount id="B3lPdr5IY0uIYf2oKyowmg" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                        <Children>
-                          <Parameter id="uZT0aD6CZkOCoanuRMTSLg" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                          <Parameter id="f3alCCVOJU6JId_EHdf82w" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="w49ejkDxfUq_1gOfF3GGCg" visible="0" canBeVaried="0" />
-                          <Observer id="WGTR8LRHdkGpvxxl0kKaTw" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
-                          <Observer id="M8U2RqEY9kmLcTX-Dae5Bw" name="Plasma Unbound" description="Plasma Unbound" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="YJ3uKXnk6UyCmv-525r6ig" displayUnit="µmol/l" />
-                        </Children>
-                      </MoleculeAmount>
-                    </Children>
-                  </Container>
-                  <Container id="HLhY21FI2UuJWgRMTu6RlA" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="BloodOrgan" />
-                      <Tag value="VenousBlood" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="Cr1RH5B4ZECdes_sjkNQcw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="c-4YDDRjEEaRS-idWwrbtg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="L6CtLSeqU0O1dIF8kt2LDQ" visible="1" canBeVaried="1" displayUnit="l" />
-                      <MoleculeAmount id="GWJuEfO1Xkqh3wAfzsLyqQ" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                        <Children>
-                          <Parameter id="827lvUyoMka7rferUu1W3w" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                          <Parameter id="ZigcaWpTt068l86TA43yFQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="TxMI51SlQEeHo_fnqjVAIQ" visible="0" canBeVaried="0" />
-                          <Observer id="rOgsO0a0lE-gKnDiFpi8ZQ" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
-                        </Children>
-                      </MoleculeAmount>
-                    </Children>
-                  </Container>
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-              <Container id="_GIHOOwIiEWT3Q30LE6Vyw" name="ArterialBlood" description="ArterialBlood" icon="ArterialBlood" mode="Logical" containerType="Organ">
-                <Tags>
-                  <Tag value="BloodOrgan" />
-                </Tags>
-                <Children>
-                  <Parameter id="nToOPT3YrUCjoUBG0P1FeQ" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="uSjt8LuoBUu75Z4-7ZUOCw" visible="0" canBeVaried="1" displayUnit="kg" />
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-                      <Parameter id="025xHahZG0CFVnpnx6jQ1Q" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.500575515426459" displayUnit="l" />
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-                      <Parameter id="RCKG3gMg9EadJUKUzVUqwg" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" value="0.016881128" displayUnit="l" />
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-                      <Tag value="ArterialBlood" />
-                      <Tag value="BloodOrgan" />
-                    </Tags>
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-                      <Parameter id="qxKRuAEDYUOsSE8rHaDM_Q" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="65W70d9dn0Ov0ppulho8MQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="InNrdVCgRUCPod7Jj5RRRw" visible="1" canBeVaried="1" displayUnit="l" />
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-                        <Children>
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-                          <Parameter id="297Q87FRSUmgrfE1VZxFlw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="sZUl8OTXY0ywWnaLvr4CuA" visible="0" canBeVaried="0" />
-                          <Observer id="eQOn3CGkkECakd8Sy8iTwA" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
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-                  <Container id="0_QXjFTwnEy8-V1CtkHsew" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="ArterialBlood" />
-                      <Tag value="BloodOrgan" />
-                    </Tags>
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-                      <Parameter id="JfOpWNMEJUOoXfk1coPjdQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="qRQ5lrDxGE6WKsxHonLURQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="L6CtLSeqU0O1dIF8kt2LDQ" visible="1" canBeVaried="1" displayUnit="l" />
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-                          <Parameter id="qoqnXlw0Lkm7QTyf7a9wQQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="FyxAWaevckO8o6DrrzmpxA" visible="0" canBeVaried="0" />
-                          <Observer id="DTf3zEdAXkOaroieQV6JWw" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
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-                  <Container id="vl7QJ_Ocd0W4-fU-nvIxpg" name="C1" mode="Logical" containerType="Molecule">
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-                    </Children>
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-                <Tags>
-                  <Tag value="Liver" />
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-                  <Parameter id="znab6r5aS0qlpi4B-XG63A" name="Gallbladder emptying rate" description="Rate of gallbladder emptying" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" visible="0" canBeVaried="0" value="0" displayUnit="µmol/min" />
-                  <Parameter id="R_Mj8gC-o0Gt3T1fukDhAw" name="Time to complete gallbladder refilling" description="Time to complete gallbladder refilling" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" formula="1GMLpkWw_0qAQitMgQPb3A" visible="1" canBeVaried="1" displayUnit="min" />
-                  <Parameter id="ZCNv7lgpcEmmrWAQf5vFrw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="l" />
-                  <Parameter id="I0KQZkrkvU-0G25F5-gCMA" name="Gallbladder ejection half-time" description="Gallbladder ejection half-time" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" visible="1" canBeVaried="1" value="19.7" displayUnit="min" />
-                  <Parameter id="SdhHOZ19nkSqR7xk6i_F6w" name="Gallbladder ejection fraction" description="Gallbladder ejection fraction" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" visible="1" canBeVaried="1" value="0.65" />
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-                      <Parameter id="DtkfaXieC0qpqzB-2kbAAQ" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                      <Observer id="IZShU5DpCUOz5b8IYJ7BzQ" name="Fraction excreted to bile" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Drug, Observer" formula="ucqtSba9z0qGMpkWbb5ibw" />
-                    </Children>
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-              <Container id="4qdUEY72nUW06pp8zN8ImQ" name="Bone" description="Bone" icon="Bone" mode="Logical" containerType="Organ">
-                <Tags>
-                  <Tag value="TissueOrgan" />
-                </Tags>
-                <Children>
-                  <Parameter id="7zsvW_V50UiHjVMWtUXBXA" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="uSjt8LuoBUu75Z4-7ZUOCw" visible="0" canBeVaried="1" displayUnit="kg" />
-                  <Parameter id="RzqxI4S6yEu0U5s4m8o2WQ" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="jdhhCNoMYE-s118HG9XzZw" visible="1" canBeVaried="1" displayUnit="l/min" />
-                  <Parameter id="p0mbRkvRFUqOBfsoMdROIA" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="-cxwem1NiE-a_jAGvZjliw" visible="1" canBeVaried="1" displayUnit="l/min" />
-                  <Parameter id="hxQSxU0M8U2lZlzx14BIkw" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="eWgukotC9UOd9gIjHiEAoQ" visible="1" canBeVaried="1" displayUnit="l/min" />
-                  <Parameter id="OQNR4EwtlUazZWSgKcL8EQ" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="jmk0yzYrokibtBSuCCVMag" visible="1" canBeVaried="0" displayUnit="l" />
-                  <Parameter id="cJ9m1x8ZA0OdYWK574nIAg" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="LSHvGCmOBEascdPo-Ab-KQ" visible="1" canBeVaried="1" />
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-                  <Parameter id="NMQm9_gd30i7enLTTifBYw" name="Peripheral blood flow fraction" description="Blood flow fraction in organ used for calculation of peripheral venous blood concentrations" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" visible="1" canBeVaried="1" value="0" />
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-                  <Parameter id="NG3dlbiRY0CLtPsYZlae-w" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                  <Parameter id="UPlgdv16O0GwKuO0XVS_GA" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.8" />
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-                  <Parameter id="R4ZlyWEHYkmH_9w-AA_j9w" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="9E-08" displayUnit="µm" />
-                  <Parameter id="k80VC0f-hEm78LS5xnZz3Q" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" visible="1" canBeVaried="1" value="3.88888888888889E-11" displayUnit="ml/min/N" />
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-                      <Parameter id="q4FJeb8wzkWqIFR7qBVv-w" name="Mean" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" value="9.5207652443088" displayUnit="l" />
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-                      <Parameter id="Jn8UDiJ3wEOvUECK33Ji3w" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="AWSLB9BqIUm588s01h4uMw" visible="1" canBeVaried="1" displayUnit="l" />
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-                <Tags>
-                  <Tag value="TissueOrgan" />
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-                <Tags>
-                  <Tag value="TissueOrgan" />
-                </Tags>
-                <Children>
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-                  <Parameter id="U-Ocm7T3RUGw3oRhE4uXlg" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="afMWeij9ZkmLvewyV0ubQQ" visible="1" canBeVaried="0" displayUnit="l" />
-                  <Parameter id="lWlCULHN0kmKqEFhpYQ_LQ" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="CJhyUEF2rkieeEsF5tq1LQ" visible="1" canBeVaried="1" displayUnit="l/min" />
-                  <Parameter id="6DS_GJ-mbEakMQIBY5wvMg" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="lmnSdl187Eahd6iRwFZhrA" visible="1" canBeVaried="1" displayUnit="l/min" />
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-                  <Parameter id="QFADU91_KEy57Myt37W9tg" name="Volume (standard kidney)" description="Volume (standard kidney)" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="0" value="0.44" displayUnit="l" />
-                  <Parameter id="qgEcHI0WoE-IW7-sIxdqfA" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.75" />
-                  <Parameter id="_altQ4dkUkWTh8CBDi75cg" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                  <Parameter id="DXS7163PBEulrLZuzp2_-w" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="4.5E-08" displayUnit="µm" />
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-                  <Parameter id="nyH6tr3R4UiddfvwgUGR5A" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.05" />
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-                        <Children>
-                          <Parameter id="sjeLhSK910eNTqktjITt6Q" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                          <Parameter id="gds4uuWev0WXmvDk1pcqNQ" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="tFRuG0BcTkCfp1lGzxb4_w" visible="0" canBeVaried="0" />
-                          <Parameter id="YVYRmiMxbU62uLTxpGGAlg" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CtoZxtyF40G6mU1E-C-gbw" visible="0" canBeVaried="0" />
-                          <Parameter id="XApZINsiykequ45fXxqNpQ" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="6howmnSOgUWoFvUztoZc-Q" visible="0" canBeVaried="0" />
-                          <Parameter id="m7L1bwpDC0GCP3Vs80d_Pg" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="gzVX_eoL6keY2BTr5In6CA" visible="0" canBeVaried="0" />
-                          <Parameter id="r-qbMYuBK0uH90zlGPZM7A" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="nh1QP8zoc0aCA5Ws4ObUFw" visible="0" canBeVaried="0" />
-                          <Parameter id="kVJesrNp5EKWrkpyYBvVKQ" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="HJBcErCLskqfcphqybq56w" visible="0" canBeVaried="0" />
-                          <Parameter id="gMCf54hcSkOnzNkp8b8w2g" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="0" value="1" />
-                          <Parameter id="hgXq6C-oQUi6TntciXFGxw" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="yYgpb2Q5SUy9FpSvv43UuQ" visible="0" canBeVaried="0" />
-                          <Parameter id="-4rS7V0AF0y_7DbLvjk6HA" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="dz2W8TF89Uaa7HOFFKblsg" visible="0" canBeVaried="0" />
-                          <Parameter id="kTo5cw0aS0unQMuAiDwJcA" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="xt6XFpUK6UqEqNbzoeBKKw" visible="0" canBeVaried="0" />
-                          <Parameter id="lNaCzrCShkOAoue4QPpKyw" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="ctJprO9AWUmtVkiYBwY72w" visible="0" canBeVaried="0" />
-                          <Parameter id="bDdoay6JJ0qtDHj6XxH23w" name="Solubility" description="Solubility" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" formula="mt08mwG6SE2z1uRWJcFFtA" visible="1" canBeVaried="1" displayUnit="mg/l" />
-                          <Parameter id="LSZwssxW7EGw2VzrgcXC8A" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="dhSNVrIzyEeZMSU6Uku8pQ" visible="0" canBeVaried="0" />
-                          <Parameter id="PSMnLVeTJEm9M8pgfvjhUw" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="aXc6LrjtKU6OCw_2wa_kjA" visible="0" canBeVaried="0" />
-                          <Observer id="Ypa5V9mecE24TK19BtSWTA" name="Concentration in lumen" description="Concentration of the molecule in lumen" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="HLIRXIitt0KZivKUJbxfRQ" displayUnit="µmol/l" />
-                        </Children>
-                      </MoleculeAmount>
-                    </Children>
-                  </Container>
-                  <Container id="RBDgGJ__rUCEJi-Z5h0eyg" name="Duodenum" description="Duodenum" icon="Duodenum" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Lumen" />
-                      <Tag value="LumenSegment" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="huSe05o9YEq6Ji-bTG3y5g" name="Proximal radius" description="Proximal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="qXWNXa9UNUq30PzJeA1etg" visible="1" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="RJKk2XDR602B1L-LMHi8Mw" name="Absorption of liquid" description="rate of liquid outflow" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="Cx7CJ5pXtkmQE3THHwSZ7g" visible="0" canBeVaried="1" displayUnit="1/min" />
-                      <Parameter id="q1d-RJRmDEOzr6mMQ6vUHw" name="Distal radius" description="Distal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="F2HrUeP5gUqsHUmUBhdDeQ" visible="1" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="Fhi20MtVykCfIdn6m4aU4A" name="FillLevelFlag" description="Fill Level Flag" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="_fdpBznEC02u7-tLvw5OGQ" visible="0" canBeVaried="1" />
-                      <Parameter id="QY1Skpw6IUWaLs3nBNJqlA" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="OyHn7MCeuk6vmTKdv-iJqA" visible="0" canBeVaried="1" />
-                      <Parameter id="P2S3VADNPESCj5X5-5eoUg" name="Geometric surface area" description="Geometric surface area of GI segment" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="9EhmHSAXZ0OXYPaSstfWrQ" visible="1" canBeVaried="1" displayUnit="cm²" />
-                      <Parameter id="hHa16HzMWUKDbuWymUnnHA" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="_qO40oypYEe7o9c_axohhQ" visible="0" canBeVaried="1" displayUnit="1/min" />
-                      <Parameter id="4sLgVBCl0kmDbkj5mcCAEA" name="Length" description="Length" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="oHVl-7jv2UWh9dAin2b_Tg" visible="1" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="BY-qnHfoFEepophDxls1ew" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="FYt0XM3NSEm1olbz1Ry5NQ" visible="0" canBeVaried="0" displayUnit="l/min" />
-                      <Parameter id="e22mFA7WlEeLBdSPSXLScw" name="Secretion of liquid" description="Rate of liquid inflow" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="ksD8HjZp7E-n2zdTsbRDHA" visible="0" canBeVaried="1" displayUnit="l/min" />
-                      <Parameter id="xXWuHkk77k6CMJcXDN92-A" name="Thickness of gut wall" description="Thickness of Gut Wall" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="PqZQXUcR2EuAADd5-fG5VQ" visible="0" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="nKrC_OaJIEmeejGIxDfD9A" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="cXeVNOGhxUGjgGD8PwjALA" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Parameter id="RKf_ZaFtwkSYaMqz1os5Gg" name="Volume (gut wall)" description="Volume of the gut wall" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="be4QsJfPPUGwk2ypJjVq4A" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Parameter id="maPARwUURkyQp3XkfCxeSQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="w_dZx0XeNEK2FQrue6H__w" name="Liquid" description="Liquid" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="2aVY-_-FqE6bH8tHqQryGA" visible="0" canBeVaried="1" rHSFormula="ILdSr3WmXkGlGKLVHvMX0g" displayUnit="l" />
-                      <Parameter id="BjDua42Hv0KpBOxKguqIuA" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="6" />
-                      <Parameter id="pm7zcCD7YUCpkW7i_7FL_Q" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.30705627" displayUnit="1/cm" />
-                      <Parameter id="x4uDVqMxWUmoFrzibcrIVg" name="Microvilli factor" description="Microvilli factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="25" />
-                      <Parameter id="gayL4QEe80KprNxz2V9TwA" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0186500479" displayUnit="cm" />
-                      <Parameter id="LPxNc35mrk6OB99EGwRM6Q" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.00925874" />
-                      <Parameter id="8bSFS_F3-0iax8POib1qiA" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0020705161" displayUnit="cm" />
-                      <Parameter id="g32WEFKnQUWNOwq-ZAKznw" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.010126747" />
-                      <Parameter id="7eaxTEJlq02SQYm8nJalMQ" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.002264627" displayUnit="cm" />
-                      <Parameter id="VxTqN_t1ikazmDwxQ13bTA" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.129622362" />
-                      <Parameter id="5_YiQC0IwUyVrYmPSfXXAg" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0289872252" displayUnit="cm" />
-                      <Parameter id="e5hLKcaosUmyqoGRj2QBiQ" name="Intestinal transit rate" description="Transit rate along intestinal segments" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" visible="0" canBeVaried="1" value="116" displayUnit="1/min" />
-                      <Parameter id="RI-YqGTMcUqDswileBLENg" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" visible="1" canBeVaried="1" value="0.06" />
-                      <Parameter id="1U6KzQEV5kavl0jE_zDccg" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0441002752" displayUnit="cm" />
-                      <DistributedParameter id="g7sv8X4c5k2UNIX3AvrJTA" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="INm5zP7fO0mY7KB-PiCiAg" mode="Logical" visible="1">
-                        <Children>
-                          <Parameter id="dQspryiGD0GN-R9o1BGbiQ" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                          <Parameter id="Y1HAe2mDpU6VinyabJB-yg" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="292.6883" />
-                        </Children>
-                      </DistributedParameter>
-                      <MoleculeAmount id="BaeHcf6VhUyw3ftOPt1iIg" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                        <Children>
-                          <Parameter id="7SaAhm76jE-TyiZyOfpUkA" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                          <Parameter id="FrfKmD2bvk-5Qv0AGe2KWg" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" visible="0" canBeVaried="0" rHSFormula="niCn2d8txEa2qSPLy3LZVQ" value="0" displayUnit="µmol" />
-                          <Parameter id="1WuKt0IOoEey86rW_uQTFA" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Dx-_lNC_PUi5tg4i5PXTKQ" visible="0" canBeVaried="0" />
-                          <Parameter id="rUbe0Mn8NUGo_n0ygXlhpA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="0" value="1" />
-                          <Parameter id="rpeaqlJIrUSQXnIjPoUoEg" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Dw_IyabHT06pZKMgIgZLug" visible="0" canBeVaried="0" />
-                          <Parameter id="36Y3rhK3fka6QB6Upl8kPg" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="PEGnAFSczUCFB1AD9gbV8g" visible="0" canBeVaried="0" />
-                          <Parameter id="kziKanoS60av1BC4t0ah0w" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="yG7za5lSzEy8vLZuU5wkUA" visible="0" canBeVaried="0" />
-                          <Parameter id="VvZ4ygrXoECQkbSSLmI2_w" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="7Ye2AKRBIEKHQosH1BcrAw" visible="0" canBeVaried="0" />
-                          <Parameter id="xdmQBvr6iEWh85nsZCc56w" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="1Km_ykFAmky-QhH3kd16xQ" visible="0" canBeVaried="0" />
-                          <Parameter id="wqZbpwqLiEmqQwZKKSsb7Q" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DKIYrF803UGNYCr8sb_Uqw" visible="0" canBeVaried="0" />
-                          <Parameter id="XsyB9bGMukiEH13F1tXgGQ" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="SDVkY49syEyB8z1yRYX0SQ" visible="0" canBeVaried="0" />
-                          <Parameter id="o8z19t5TDUWAj4dU8kHgiA" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="tnEtuIIrr0OBxbRFffEeog" visible="0" canBeVaried="0" />
-                          <Parameter id="bXHLTpbN6UCSXWNa_t5Zaw" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="ggY0rrsSrU-e3M7Gx9UwCw" visible="0" canBeVaried="0" />
-                          <Parameter id="KexqJbluG0SP3OkI7oVtIw" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="1MdvdFtFAEizb0iSLwDnZg" visible="0" canBeVaried="0" />
-                          <Parameter id="3UnqnJ17VEa6HWhZgEIfQA" name="Solubility" description="Solubility" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" formula="IX-iw63VFkG_5gjIvH9ADA" visible="1" canBeVaried="1" displayUnit="mg/l" />
-                          <Parameter id="lSkARzEBDEeBNgehh7YEJw" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="qq9-PdL5iEi2q4aukONsKw" visible="0" canBeVaried="0" />
-                          <Observer id="HVRaI8SaD0WT1aCODifQxw" name="Concentration in lumen" description="Concentration of the molecule in lumen" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="HLIRXIitt0KZivKUJbxfRQ" displayUnit="µmol/l" />
-                          <Observer id="oE1quVCYWkeycZQnaQjUhg" name="Fraction of oral drug mass absorbed into mucosa segment" description="Fraction of oral drug mass absorbed into mucosa segment" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Drug, Observer" formula="XKRnaHqlW0S6GDKupu_dRA" />
-                        </Children>
-                      </MoleculeAmount>
-                    </Children>
-                  </Container>
-                  <Container id="CiHSzBkCCUudCrF-9qgurw" name="UpperJejunum" description="Upper Jejunum" icon="UpperJejunum" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Lumen" />
-                      <Tag value="LumenSegment" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="PbQ-Gzo9XEGfBoi4ALS7lA" name="Geometric surface area" description="Geometric surface area of GI segment" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="9EhmHSAXZ0OXYPaSstfWrQ" visible="1" canBeVaried="1" displayUnit="cm²" />
-                      <Parameter id="vGvTxqRMaE-kp1UXdwg2kA" name="Length" description="Length" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="oHVl-7jv2UWh9dAin2b_Tg" visible="1" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="7im3zR7-HEa1XO48xsNQ5A" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="9cu0xtLbe0yJUIr_qTyTQg" visible="0" canBeVaried="0" displayUnit="l/min" />
-                      <Parameter id="_ndm5JUHa0yrdftumFBrLg" name="Proximal radius" description="Proximal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="qXWNXa9UNUq30PzJeA1etg" visible="1" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="QwxB7bkva0GNJaLjiKVh9w" name="Secretion of liquid" description="Rate of liquid inflow" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="aXkL7QBgEUG6QFMQYI5LUw" visible="0" canBeVaried="1" displayUnit="l/min" />
-                      <Parameter id="V4crhPoULU2Fgyg8IdBJow" name="Thickness of gut wall" description="Thickness of Gut Wall" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="PqZQXUcR2EuAADd5-fG5VQ" visible="0" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="4siWomwSlkiivpbmXkzQQg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="cXeVNOGhxUGjgGD8PwjALA" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Parameter id="OGjxBPEVNEOgpyAj3_klZg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="Gp0aFmBx7kKURGVxZAipYQ" name="Volume (gut wall)" description="Volume of the gut wall" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="cqhQCc4hw0OtUcRkOpcrTQ" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Parameter id="BEp5BmmESEmvekyg7xggpw" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="Noz4813aI0q6J4nYyCRNxw" visible="0" canBeVaried="1" displayUnit="1/min" />
-                      <Parameter id="48fixL4OlU6bxL6gUlq4Qw" name="Liquid" description="Liquid" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="2aVY-_-FqE6bH8tHqQryGA" visible="0" canBeVaried="1" rHSFormula="LegR7LtHwEm3PLkklvMuvw" displayUnit="l" />
-                      <Parameter id="rv1SFSDGG0CLcBZeEFEfPA" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="OyHn7MCeuk6vmTKdv-iJqA" visible="0" canBeVaried="1" />
-                      <Parameter id="FuqY6_nkLkSBBCOB9ygEbQ" name="Absorption of liquid" description="rate of liquid outflow" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="TEw4LQuM0UOCo4pEWNLLaw" visible="0" canBeVaried="1" displayUnit="1/min" />
-                      <Parameter id="BM8ic5FcikelXYUoHLWNgg" name="Distal radius" description="Distal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="F2HrUeP5gUqsHUmUBhdDeQ" visible="1" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="We6mamA88EKt4e-2RcG7PA" name="FillLevelFlag" description="Fill Level Flag" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="_fdpBznEC02u7-tLvw5OGQ" visible="0" canBeVaried="1" />
-                      <Parameter id="u75MvWDrJ0CmdcPd_PWYKQ" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="6.25" />
-                      <Parameter id="BpgfCYWmxkqcfhXfq0LQwQ" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.30703115" displayUnit="1/cm" />
-                      <Parameter id="SkH6juzWBUOddVd7d4uOVQ" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.299751712" />
-                      <Parameter id="h9jGd_VUCEqJFK26aFlhyw" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.00925874" />
-                      <Parameter id="yH4xFPp_7Eu9la02ERmqIQ" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0020705161" displayUnit="cm" />
-                      <Parameter id="51zp7QiTOUKMu6HfUQ4_Bg" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0670329582" displayUnit="cm" />
-                      <Parameter id="9dgOO-txAUuqrcQtoDK7oQ" name="Intestinal transit rate" description="Transit rate along intestinal segments" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" visible="0" canBeVaried="1" value="5.0162" displayUnit="1/min" />
-                      <Parameter id="TnDUOzycz0-mO9VuBAdCwA" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" visible="1" canBeVaried="1" value="0.064841" />
-                      <Parameter id="b30okq-_T0yljeVzWb7L7g" name="Microvilli factor" description="Microvilli factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="25" />
-                      <Parameter id="DpCIdmk3PEab_DRKoyjcAg" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0589752766" displayUnit="cm" />
-                      <Parameter id="_n3adhQ8-k2waVJEkWnWkw" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.024936327" displayUnit="cm" />
-                      <Parameter id="t0cJnRuWS0i_OcfE5p_Hxg" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.008680069" />
-                      <Parameter id="SEZK39f3G06iTf0m3G14wQ" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0019411088" displayUnit="cm" />
-                      <DistributedParameter id="eWo5o6BitEqIoehlT-JWDg" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="oJsfF0ZMAkO6HKeQKsL43w" mode="Logical" visible="1">
-                        <Children>
-                          <Parameter id="z_7B-JhTSUWugby-AA-X3Q" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                          <Parameter id="g77T-QYntUeC3S3HEJyDwg" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="447.9877" />
-                        </Children>
-                      </DistributedParameter>
-                      <MoleculeAmount id="V3v2rXqlRkujCVZ10rY3Ew" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                        <Children>
-                          <Parameter id="XzhtOsLP_k6dlIM0XaguyQ" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                          <Parameter id="PMbv-rzKpESNMEZvtzESNA" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IsTy33WB7ESR5_r-VDq4fA" visible="0" canBeVaried="0" />
-                          <Parameter id="3QR2TKaRRkqKC33ShQY1HA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="0" value="1" />
-                          <Parameter id="WMHAMZ6RaEar3qIlhSoNdA" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" visible="0" canBeVaried="0" rHSFormula="NDyMOymwm0yQw66TMuGSzQ" value="0" displayUnit="µmol" />
-                          <Parameter id="reDRrAsWe0Gft0qXkhCU7g" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DGEyVJxGRkK1vFKyY5Tb9w" visible="0" canBeVaried="0" />
-                          <Parameter id="9MSnMPzfK0C9zT8JYc4PVQ" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="xrez3w0g7UG-7-jsKxCtig" visible="0" canBeVaried="0" />
-                          <Parameter id="6e1EiU6JY0WpdSJ4pQyXeg" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="egztF40wwUyqvhK0oLwQZg" visible="0" canBeVaried="0" />
-                          <Parameter id="O0c9EHP8-0qrS7N4d8mrzw" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="3znCqMJedEeWcAqkoCQ7KA" visible="0" canBeVaried="0" />
-                          <Parameter id="rDNqgghbkEGBokaaF07lHQ" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="60q4D_3sgEOZGHAq37qGPw" visible="0" canBeVaried="0" />
-                          <Parameter id="ubkda2dEeUSOzyNiGfZtgA" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="plRy4piBG0OEqMb8trbv9g" visible="0" canBeVaried="0" />
-                          <Parameter id="wbV2YZywgEyV105Pc3lpcA" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IwQRVVSHzEWQSoTgefz5sQ" visible="0" canBeVaried="0" />
-                          <Parameter id="0csVeX7Tt0e2JGpVcCY-fQ" name="Solubility" description="Solubility" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" formula="tsOOTnC2UU2zmISrBvAOFQ" visible="1" canBeVaried="1" displayUnit="mg/l" />
-                          <Parameter id="zTXlIi0vXUKE4eGtTQ8-xg" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="J7Qsvqqb1keTr_tdW5wegw" visible="0" canBeVaried="0" />
-                          <Parameter id="D4KvVUTZykysUW1H7BrKWw" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="iloq2e2E40ePf5b_qWcdrg" visible="0" canBeVaried="0" />
-                          <Parameter id="qY6e1P053EiLuJ6w6ZqEdQ" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="gs9y_Kr0aE-bk5yS02Kq_g" visible="0" canBeVaried="0" />
-                          <Parameter id="RkE3u2ZTYUmG4KBPD0yiAQ" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="nyHnmg867k6GLa5z6gLmUg" visible="0" canBeVaried="0" />
-                          <Observer id="vY-A-iYK70yqE_OpChh_zw" name="Concentration in lumen" description="Concentration of the molecule in lumen" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="HLIRXIitt0KZivKUJbxfRQ" displayUnit="µmol/l" />
-                          <Observer id="AX0j6JOR6k2o7wUDuUSwnQ" name="Fraction of oral drug mass absorbed into mucosa segment" description="Fraction of oral drug mass absorbed into mucosa segment" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Drug, Observer" formula="XKRnaHqlW0S6GDKupu_dRA" />
-                        </Children>
-                      </MoleculeAmount>
-                    </Children>
-                  </Container>
-                  <Container id="MLkuT5b_ikmcYGRo2SAH3w" name="LowerJejunum" description="Lower Jejunum" icon="LowerJejunum" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Lumen" />
-                      <Tag value="LumenSegment" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="Rh4-o_scxki6bg6wPoyNXA" name="Volume (gut wall)" description="Volume of the gut wall" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="5y-0vqa4JEemn4qhaahvtg" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Parameter id="0K_fLjSrwkSJqNJg5xr4XQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="3tEyn06QHUaVxdoQ5QlHbA" name="Thickness of gut wall" description="Thickness of Gut Wall" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="PqZQXUcR2EuAADd5-fG5VQ" visible="0" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="hwwvAYYxC0agxuQfyHCRvw" name="Absorption of liquid" description="rate of liquid outflow" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="JgTYtaJfgEeLQD1AOzsihw" visible="0" canBeVaried="1" displayUnit="1/min" />
-                      <Parameter id="IsYPLbObaE-oShAZg4UK7g" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="cXeVNOGhxUGjgGD8PwjALA" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Parameter id="HnJdO705Lku9uhsnqiHiyQ" name="Distal radius" description="Distal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="F2HrUeP5gUqsHUmUBhdDeQ" visible="1" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="uPTGnsQfFEqvjz7awJpZPA" name="FillLevelFlag" description="Fill Level Flag" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="_fdpBznEC02u7-tLvw5OGQ" visible="0" canBeVaried="1" />
-                      <Parameter id="RGn1gJe9gkeW82Mo_9EX9w" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="OyHn7MCeuk6vmTKdv-iJqA" visible="0" canBeVaried="1" />
-                      <Parameter id="nCQV-vgw1EKUg-7oEwsImA" name="Geometric surface area" description="Geometric surface area of GI segment" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="9EhmHSAXZ0OXYPaSstfWrQ" visible="1" canBeVaried="1" displayUnit="cm²" />
-                      <Parameter id="8FTPaCYjakCXVcCXw6PZVA" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="Tc9frTEJLEyjWc-GvMys4g" visible="0" canBeVaried="1" displayUnit="1/min" />
-                      <Parameter id="Ufwt6IW1S0Csl5emoaMh7g" name="Length" description="Length" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="oHVl-7jv2UWh9dAin2b_Tg" visible="1" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="-xp8M8cneU68478bap8lfg" name="Liquid" description="Liquid" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="2aVY-_-FqE6bH8tHqQryGA" visible="0" canBeVaried="1" rHSFormula="3jroF04BMEOlyDLq4bRBAw" displayUnit="l" />
-                      <Parameter id="BkfZkVJiAEC8I4CkUPsJOQ" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="OkfQePrBfECGA3hs1qqX1A" visible="0" canBeVaried="0" displayUnit="l/min" />
-                      <Parameter id="JoBjsGxUAESOId11nVgIFw" name="Proximal radius" description="Proximal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="qXWNXa9UNUq30PzJeA1etg" visible="1" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="ukD7OmUT2EudtNOzJFkPBQ" name="Secretion of liquid" description="Rate of liquid inflow" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="1vNrydfJ5Em-7phSE4PkuA" visible="0" canBeVaried="1" displayUnit="l/min" />
-                      <Parameter id="km-HRFESjECaI1BIcJgyMQ" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0019411088" displayUnit="cm" />
-                      <Parameter id="c4LQhw4oWEep_J5CgPCVCA" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.30703115" displayUnit="1/cm" />
-                      <Parameter id="0keC_4LN-EKAuAMoiQHuzQ" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0465856499" displayUnit="cm" />
-                      <Parameter id="cjD6y-wiU0CH5PrEW2Vk2g" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.008101398" />
-                      <Parameter id="4tgCSloTtkW6PonYEGIAcw" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0018117016" displayUnit="cm" />
-                      <Parameter id="j-vTOgiH002W4jK-P1g3PQ" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.008680069" />
-                      <Parameter id="Gd7g8Hgzbki_kEowd0QkWw" name="Microvilli factor" description="Microvilli factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="25" />
-                      <Parameter id="XDlXiAyqLkSSQRDWTXUyoQ" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.299751712" />
-                      <Parameter id="Zn6etmCVw0CFVB_yAbMJvA" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0670329582" displayUnit="cm" />
-                      <Parameter id="enoqzbClLkaob1w6Wl0DSQ" name="Intestinal transit rate" description="Transit rate along intestinal segments" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" visible="0" canBeVaried="1" value="5.0162" displayUnit="1/min" />
-                      <Parameter id="oyp8hHf_0k6h2wSoqyY7dQ" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" visible="1" canBeVaried="1" value="0.064841" />
-                      <Parameter id="aHL_svOpoUSHpB58LTTsOQ" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0196976609" displayUnit="cm" />
-                      <Parameter id="Nfy_U5sDzUSUFhpePv7MHw" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="6.9167" />
-                      <DistributedParameter id="IYLd1oXNbUaW_GXTW5XCFw" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="2Kt5caoHS0KdWbYKUfpdtg" mode="Logical" visible="1">
-                        <Children>
-                          <Parameter id="8-lj-7XBH0WzaL12T7Df6Q" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                          <Parameter id="1IrGHJVf5UiVQq7DRVIi9w" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="372.9358" />
-                        </Children>
-                      </DistributedParameter>
-                      <MoleculeAmount id="Cuam5DbmZ0uqXwc9apFicg" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                        <Children>
-                          <Parameter id="EB64GfTPNkmOODmff2h4Gw" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                          <Parameter id="KQdUMC9ryEC7mBy-KarAFw" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="aN4I8buWo0eEk3yngEwT1w" visible="0" canBeVaried="0" />
-                          <Parameter id="8WTiL1Jj5UuAY31GkWsEqg" name="Solubility" description="Solubility" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" formula="Xt2eLR0Fa02jdW78uLhbeA" visible="1" canBeVaried="1" displayUnit="mg/l" />
-                          <Parameter id="A-O_scOQ-kGx0Gsf8S-OFg" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="iW9FGMf5rUu1J2AusqLApw" visible="0" canBeVaried="0" />
-                          <Parameter id="JQPum47tzUSuDii9kswesA" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="sFS16zII8UK80_G7p1CNMw" visible="0" canBeVaried="0" />
-                          <Parameter id="hPM6EEAux06JMGWQ-g4cAw" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" visible="0" canBeVaried="0" rHSFormula="93Q7I5MNFUq-uvM82-0r7A" value="0" displayUnit="µmol" />
-                          <Parameter id="nzdV5sS6-UyJ3vDr3suAug" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="-NfWkhhIYUWlzx1o9KPaVA" visible="0" canBeVaried="0" />
-                          <Parameter id="6vVJ1bzPukOaVm3_c8rFPw" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="YWy1DTlQVEGVQOcF-QNnlw" visible="0" canBeVaried="0" />
-                          <Parameter id="Gayjg4SzRUmES1ov_iD62Q" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="0" value="1" />
-                          <Parameter id="sqL6geOYZEyaP5dMmgw2TA" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="4pUB8pmQgUWSS3Zu4w1XWg" visible="0" canBeVaried="0" />
-                          <Parameter id="gbQDVDdImEWv3cE45ZwIXg" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Lo5toJ2Mb065Qge7yKCOTg" visible="0" canBeVaried="0" />
-                          <Parameter id="URJVlIkKOU6hTibxSTPTng" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="zp8h2QnihUeWKVIZolKKeQ" visible="0" canBeVaried="0" />
-                          <Parameter id="WEBxnbLBakqj34P1CvtMXA" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="qjHjURg7RE6cCRbY7lHGag" visible="0" canBeVaried="0" />
-                          <Parameter id="pNtss7ruZ0OTMU67TcSY5A" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="SiI4XqqmmkaX7lcZ8xHEXQ" visible="0" canBeVaried="0" />
-                          <Parameter id="qa9HDT0jRkSoeXUky3fRFw" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="p8AguT_fqkiiquvWRLPnDQ" visible="0" canBeVaried="0" />
-                          <Parameter id="r1lzC5wavU-x4hbEN9qtKw" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="bwD7i3vWBkqOb2zpTiYd5g" visible="0" canBeVaried="0" />
-                          <Observer id="go_OIBe0uUeuRgXJXfvs1w" name="Concentration in lumen" description="Concentration of the molecule in lumen" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="HLIRXIitt0KZivKUJbxfRQ" displayUnit="µmol/l" />
-                          <Observer id="whh6NYVIa0ihOsujk4D5mw" name="Fraction of oral drug mass absorbed into mucosa segment" description="Fraction of oral drug mass absorbed into mucosa segment" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Drug, Observer" formula="XKRnaHqlW0S6GDKupu_dRA" />
-                        </Children>
-                      </MoleculeAmount>
-                    </Children>
-                  </Container>
-                  <Container id="Ybii6aaw1UeIsuUX1COdYA" name="UpperIleum" description="Upper Ileum" icon="UpperIleum" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Lumen" />
-                      <Tag value="LumenSegment" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="wBj13kswJ02DJ3y53lSdIg" name="Secretion of liquid" description="Rate of liquid inflow" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="8o2JffWnMEam08XCYp6jtA" visible="0" canBeVaried="1" displayUnit="l/min" />
-                      <Parameter id="eZGkbfGar0mp2WFZ2RPsmA" name="Absorption of liquid" description="rate of liquid outflow" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="qymnPCBqoUiatZ4K3RdVzQ" visible="0" canBeVaried="1" displayUnit="1/min" />
-                      <Parameter id="78dFpGN9_0KzqV8iQebcPQ" name="Distal radius" description="Distal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="F2HrUeP5gUqsHUmUBhdDeQ" visible="1" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="rzdUVHAe6k-g4cvWzZS1dA" name="FillLevelFlag" description="Fill Level Flag" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="_fdpBznEC02u7-tLvw5OGQ" visible="0" canBeVaried="1" />
-                      <Parameter id="wsI46siIYEWtypjT25EwrA" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="OyHn7MCeuk6vmTKdv-iJqA" visible="0" canBeVaried="1" />
-                      <Parameter id="M-d1_m-mtUqGKzn1fHZNPg" name="Geometric surface area" description="Geometric surface area of GI segment" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="9EhmHSAXZ0OXYPaSstfWrQ" visible="1" canBeVaried="1" displayUnit="cm²" />
-                      <Parameter id="mbqJClRUeE6HWfriLgrxrg" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="cK8DjFkxEEGNUGx8llaOEA" visible="0" canBeVaried="1" displayUnit="1/min" />
-                      <Parameter id="oUHsaWuhHUqourM8arVUHQ" name="Length" description="Length" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="oHVl-7jv2UWh9dAin2b_Tg" visible="1" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="CRUdRj6n6kCZZnkvQnlYXg" name="Liquid" description="Liquid" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="2aVY-_-FqE6bH8tHqQryGA" visible="0" canBeVaried="1" rHSFormula="Wn5N2ABJf0ugRFlwrMSCrg" displayUnit="l" />
-                      <Parameter id="-5v_Pb2n-kinRWptolkKMQ" name="Proximal radius" description="Proximal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="qXWNXa9UNUq30PzJeA1etg" visible="1" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="5Ei6ZtEGCECRuCu0QCgHPQ" name="Thickness of gut wall" description="Thickness of Gut Wall" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="PqZQXUcR2EuAADd5-fG5VQ" visible="0" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="gybLE8_mCUGtNvtTK93XDQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="cXeVNOGhxUGjgGD8PwjALA" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Parameter id="gnsuB_wO00aeEY7f7qRdjQ" name="Volume (gut wall)" description="Volume of the gut wall" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="G7NxAykhCkSmNAYqluQxHQ" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Parameter id="TGCafDxTGEGxV9qJdcnFPA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="eMAMqgAaTEi_g4yldM83oA" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="pW3iUdfCO0-C_1badwoTyA" visible="0" canBeVaried="0" displayUnit="l/min" />
-                      <Parameter id="lCyREYTWj02vE6E62sXz1w" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.30703115" displayUnit="1/cm" />
-                      <Parameter id="p96fDagob0aSthvRhUrI2g" name="Intestinal transit rate" description="Transit rate along intestinal segments" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" visible="0" canBeVaried="1" value="3.3745" displayUnit="1/min" />
-                      <Parameter id="CeK12q1beEe2WR2ruDjdvA" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.061552122" displayUnit="cm" />
-                      <Parameter id="y5FBicCyZUC5Fyg4h3QW3w" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0260258863" displayUnit="cm" />
-                      <Parameter id="1jbmC8bpA0KgrB49dIEGTg" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.006944055" />
-                      <Parameter id="0lorbhBr7EeQAkRG8PYZqQ" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0015528871" displayUnit="cm" />
-                      <Parameter id="uQs94P9FsEegAIJrF0ulsw" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.008101398" />
-                      <Parameter id="3DV47zUn70KBFbroKchL-g" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0018117016" displayUnit="cm" />
-                      <Parameter id="Yvmbnm5LK0Kn3Bq-OgWLHw" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" visible="1" canBeVaried="1" value="0.064841" />
-                      <Parameter id="pQLMqh79cUm5WHVbkcE1-Q" name="Microvilli factor" description="Microvilli factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="25" />
-                      <Parameter id="KuHX_sS6_UmHu-zwZg7uzA" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.445576869" />
-                      <Parameter id="EtndjdcpN0-Lr_lyF4EXKA" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0996435866" displayUnit="cm" />
-                      <Parameter id="XCym0yfXpEu5w1Lkw5yqZw" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.2083" />
-                      <DistributedParameter id="YohPSPqvwkWc56ngHshpXg" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="QH4UVsJwgUK07576h4AXig" mode="Logical" visible="1">
-                        <Children>
-                          <Parameter id="6vBXTr6BJUmpwYTvoMvaXw" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                          <Parameter id="glJ2gGQatUy6zaUKrAS2vA" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="260.7527" />
-                        </Children>
-                      </DistributedParameter>
-                      <MoleculeAmount id="xrlOSQNSBk-WGtZ7E-tEYw" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                        <Children>
-                          <Parameter id="iqt33HrrUEauhSjXF32DDw" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                          <Parameter id="uvUyWM7tgkSMHqZ0KBhNKA" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="bEVArdud1UGoZClrP3zo4g" visible="0" canBeVaried="0" />
-                          <Parameter id="5I8jbeiYSEuo2tz6gn9uww" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="JTP53IXrY0izGazaDqvvOQ" visible="0" canBeVaried="0" />
-                          <Parameter id="4HTkyl4DeUG0rTILjiOJ6Q" name="Solubility" description="Solubility" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" formula="FE9I-0kS8U2LA87Fb9APRg" visible="1" canBeVaried="1" displayUnit="mg/l" />
-                          <Parameter id="VGhzw__pWUC8Tq6PMRkqeQ" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="5LpWfdD_3kyOVaUIMQF8VA" visible="0" canBeVaried="0" />
-                          <Parameter id="DlvYyiSY50Gv918UsWXcyw" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BaoRoUEU2UinYhBcx3m7jw" visible="0" canBeVaried="0" />
-                          <Parameter id="4qSh4a2Y9EWqSNZucJW3hg" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="x-bIoOLEN0uxHaok7r6tOQ" visible="0" canBeVaried="0" />
-                          <Parameter id="TgOljyGjTUuo0sv0SkdcFQ" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="22IcA-bwP0WqKlOmyW-zDA" visible="0" canBeVaried="0" />
-                          <Parameter id="Cs86QNz8mkaWFmPefYnBYQ" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="AYz2QZjvZ0i2aQHJjl2AAw" visible="0" canBeVaried="0" />
-                          <Parameter id="OAXhgGX3UUSJnW3wQkDiHw" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="y-o_V2ISm06ZaFGZ5AXfbA" visible="0" canBeVaried="0" />
-                          <Parameter id="OhxW82r4I06RnBZd39ItoQ" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="knY6neYWUEek-ea_6E3jwA" visible="0" canBeVaried="0" />
-                          <Parameter id="uIsAuWn-DU6Z8LDr9RmSjg" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Onw5UqcBPE-qGQUvnTOKmQ" visible="0" canBeVaried="0" />
-                          <Parameter id="a5PIF7a8c0qk5kF2fRCoRg" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="FE2wBp5sF0KmWnbZUSwTBQ" visible="0" canBeVaried="0" />
-                          <Parameter id="dGWJZXI0TEWXYRnfl7Zgdw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="0" value="1" />
-                          <Parameter id="IzdqD0pqWECNLdX6TjpT8g" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" visible="0" canBeVaried="0" rHSFormula="FVx3U8qJfUu4rlWDPFgYug" value="0" displayUnit="µmol" />
-                          <Parameter id="p1r_2ixB8kW5TSxG7TrJmg" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="_-S90FYJ6ESeogTlHl7R6Q" visible="0" canBeVaried="0" />
-                          <Observer id="Kl-SE_gEOE2j8MQkG_HhTg" name="Concentration in lumen" description="Concentration of the molecule in lumen" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="HLIRXIitt0KZivKUJbxfRQ" displayUnit="µmol/l" />
-                          <Observer id="-zhMNQcRFUyeOttrcF--xA" name="Fraction of oral drug mass absorbed into mucosa segment" description="Fraction of oral drug mass absorbed into mucosa segment" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Drug, Observer" formula="XKRnaHqlW0S6GDKupu_dRA" />
-                        </Children>
-                      </MoleculeAmount>
-                    </Children>
-                  </Container>
-                  <Container id="igIrhkz7s0ehw7sHmKiBCg" name="LowerIleum" description="Lower Ileum" icon="LowerIleum" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Lumen" />
-                      <Tag value="LumenSegment" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="iEZLc8GZCUydSaX7qbCHtw" name="Geometric surface area" description="Geometric surface area of GI segment" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="9EhmHSAXZ0OXYPaSstfWrQ" visible="1" canBeVaried="1" displayUnit="cm²" />
-                      <Parameter id="Vf6MYykNzkyjFx6Pxe2cpg" name="Absorption of liquid" description="rate of liquid outflow" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="s_0soFODbUKpetWjYSVLkg" visible="0" canBeVaried="1" displayUnit="1/min" />
-                      <Parameter id="x7aiVgNZhk6X8al_MMFWjg" name="Distal radius" description="Distal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="F2HrUeP5gUqsHUmUBhdDeQ" visible="1" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="BubBnagzOkOAwT4CV4_Avw" name="FillLevelFlag" description="Fill Level Flag" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="_fdpBznEC02u7-tLvw5OGQ" visible="0" canBeVaried="1" />
-                      <Parameter id="dL9ufXOacUa41HSeaz_Ttw" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="Aj_NKEe8dkaRrZZFhRG4AA" visible="0" canBeVaried="1" displayUnit="1/min" />
-                      <Parameter id="jJapZ__rxUKjIMc0Lm-j1w" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="OyHn7MCeuk6vmTKdv-iJqA" visible="0" canBeVaried="1" />
-                      <Parameter id="cDBWZxwH3UCVAw26SFPaJg" name="Length" description="Length" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="oHVl-7jv2UWh9dAin2b_Tg" visible="1" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="ip2AAJNEG06lzhz9rnMCxA" name="Liquid" description="Liquid" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="2aVY-_-FqE6bH8tHqQryGA" visible="0" canBeVaried="1" rHSFormula="LupifbBVBEmekdHepYm0uQ" displayUnit="l" />
-                      <Parameter id="Q9517o0zTky4NFoxS3K8Lw" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="JP4_CmiR_kSxPAny5r2wxQ" visible="0" canBeVaried="0" displayUnit="l/min" />
-                      <Parameter id="P68w6wKAR0KMzjI_ZqTqzQ" name="Proximal radius" description="Proximal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="qXWNXa9UNUq30PzJeA1etg" visible="1" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="qf5NkZNzFEOC-OL8vbtrpA" name="Secretion of liquid" description="Rate of liquid inflow" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="thQOio6F7kewxcu6s2S89Q" visible="0" canBeVaried="1" displayUnit="l/min" />
-                      <Parameter id="Ftv9jS_ewU6jR67L-IFEvw" name="Thickness of gut wall" description="Thickness of Gut Wall" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="PqZQXUcR2EuAADd5-fG5VQ" visible="0" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="002YGAfWcEyVx4FkS83y6w" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="cXeVNOGhxUGjgGD8PwjALA" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Parameter id="L1EUSZllLE-YvOi9wFRzqg" name="Volume (gut wall)" description="Volume of the gut wall" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="isgoO6erJ0G64fE4n2H0uw" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Parameter id="kdqXg0ODvkSG0fZRFNxgmg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="8q9Z0DFxyUOVRGM7VfXW5Q" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" visible="1" canBeVaried="1" value="0.064841" />
-                      <Parameter id="ijK3iAVlLEmJj9M-mR-YCg" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0015528871" displayUnit="cm" />
-                      <Parameter id="U4bZ83f0JEar-myld429jw" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.30705627" displayUnit="1/cm" />
-                      <Parameter id="cobkBNBWpkGjkvrHX6EtrQ" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0350288649" displayUnit="cm" />
-                      <Parameter id="K1uhaN7Hika5_4ruH8jj6A" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0148137399" displayUnit="cm" />
-                      <Parameter id="QolCOrF9cEOEmWzUABB4Wg" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.005786713" />
-                      <Parameter id="vTSqnIsO8Ey7PNV279IY8w" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0012940725" displayUnit="cm" />
-                      <Parameter id="MJ-V8YuMN0GythPuB45cPQ" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.006944055" />
-                      <Parameter id="IdZwVNB0Hk6q0q481XykKQ" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.4583" />
-                      <Parameter id="TvWzlTetiUe6bty6Oob96g" name="Microvilli factor" description="Microvilli factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="25" />
-                      <Parameter id="uHceWaSnF0Gdr4cKBTnL0A" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.445576869" />
-                      <Parameter id="EYKeRhy4cUCSYU0ryH8QXw" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0996435866" displayUnit="cm" />
-                      <Parameter id="kh1iGCziFUyxlIPzZ7WebQ" name="Intestinal transit rate" description="Transit rate along intestinal segments" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" visible="0" canBeVaried="1" value="3.3745" displayUnit="1/min" />
-                      <DistributedParameter id="dxXYj4EJz0C9Ptoy0ZIDpw" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Vp8V_Q5xtU2pqdB7Yitbzw" mode="Logical" visible="1">
-                        <Children>
-                          <Parameter id="tjEQ1fWm4k2VHjbY5CZfIQ" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                          <Parameter id="7DMqe2AIoEmPd-zBz9bckA" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="146.565" />
-                        </Children>
-                      </DistributedParameter>
-                      <MoleculeAmount id="yw7rzbgJB0-l91_K8hz0sQ" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                        <Children>
-                          <Parameter id="NCGc1sgqB0WEepZMnmfj2w" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                          <Parameter id="hsl1q3FJRESyFifKCNZ_Hg" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="aIQxfz9QUEyGsLuHEO5Bgg" visible="0" canBeVaried="0" />
-                          <Parameter id="0_V0IhOVBE-82_jRMAtFvg" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" visible="0" canBeVaried="0" rHSFormula="MXQvgCsf9EiDrJgGVB91CQ" value="0" displayUnit="µmol" />
-                          <Parameter id="mHhJOdVLIEKbcwWH_MjDbw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="0" value="1" />
-                          <Parameter id="IT0cP1pYEUSzvLfMUiAVFw" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="OKpCXeOwvECRC2uDAGa-Yw" visible="0" canBeVaried="0" />
-                          <Parameter id="5GfsHYzYEEu_RzfQgspfKQ" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="7LL5Sb4f9Eqx7f99vqQKag" visible="0" canBeVaried="0" />
-                          <Parameter id="zlLQos0b-EigJOk_GaJV_A" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="zdAD-bmpPk-Mn9f-7CUt2g" visible="0" canBeVaried="0" />
-                          <Parameter id="UUvr8lhmvEmoBkI_hjZBwA" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="9_-jU0R0wUm4FFRuuvoDrw" visible="0" canBeVaried="0" />
-                          <Parameter id="9kpzAxTDCkWRmdbr64mABw" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="gPL6P9lkC0WRunhtCanL5w" visible="0" canBeVaried="0" />
-                          <Parameter id="WFDFS4u3aEKF88x5McGkTg" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="ntLRgZ_YBEypjXOnyfSFsA" visible="0" canBeVaried="0" />
-                          <Parameter id="sWsIzf1oX0KRvARoojzdWw" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="2qR4-Q_dF0qG7bDvwITD9A" visible="0" canBeVaried="0" />
-                          <Parameter id="TGokp3uqv0qPMZ9l4ex9nw" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="2TwYTvs_3Uym8juLZkUwcA" visible="0" canBeVaried="0" />
-                          <Parameter id="gnzzNyETkE-44GQM7cyAng" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="htoNv4JQiUCg6cLx_IGNZQ" visible="0" canBeVaried="0" />
-                          <Parameter id="aymuK0FZTUyOn1cO983e6g" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="9qw9_EzVekiYMI1JMxSBVw" visible="0" canBeVaried="0" />
-                          <Parameter id="7JRyX4kJHkOyPK2PvhCCDQ" name="Solubility" description="Solubility" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" formula="2XepGwIJ10CHcpnFwYN2HA" visible="1" canBeVaried="1" displayUnit="mg/l" />
-                          <Parameter id="l153DMdGtEaqnupiogGLqQ" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="MHsXYLFYY0yZVJCwqVw22g" visible="0" canBeVaried="0" />
-                          <Observer id="Gd1v8-mYnEOaX5TGGQ8Ztw" name="Concentration in lumen" description="Concentration of the molecule in lumen" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="HLIRXIitt0KZivKUJbxfRQ" displayUnit="µmol/l" />
-                          <Observer id="kYwFCQ6VzkaiQ_IufhsOmg" name="Fraction of oral drug mass absorbed into mucosa segment" description="Fraction of oral drug mass absorbed into mucosa segment" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Drug, Observer" formula="XKRnaHqlW0S6GDKupu_dRA" />
-                        </Children>
-                      </MoleculeAmount>
-                    </Children>
-                  </Container>
-                  <Container id="jlQkJ9VHjEatlpKzMFmnlw" name="Caecum" description="Cecum" icon="Caecum" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Lumen" />
-                      <Tag value="LumenSegment" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="ETtNy8fPXUu3H76A6Zwniw" name="Volume (gut wall)" description="Volume of the gut wall" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="PFC67js_70youvGPUOKj7g" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Parameter id="IKYh-NES4ECM3dl1m81orA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="fGJXJxYEb0G-wRofBkXWuQ" name="Distal radius" description="Distal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="F2HrUeP5gUqsHUmUBhdDeQ" visible="1" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="y5j4hD93U0GraxWprT9Gcg" name="Absorption of liquid" description="rate of liquid outflow" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="f9HBe0HL8UmV2kHSSUfujQ" visible="0" canBeVaried="1" displayUnit="1/min" />
-                      <Parameter id="Sbz_kzny5UOeerYdOhjiew" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="cXeVNOGhxUGjgGD8PwjALA" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Parameter id="pKukkTOflUWhvHNziVO59w" name="FillLevelFlag" description="Fill Level Flag" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="_fdpBznEC02u7-tLvw5OGQ" visible="0" canBeVaried="1" />
-                      <Parameter id="ZHhp4Pw270qkLneE4j4VRA" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="OyHn7MCeuk6vmTKdv-iJqA" visible="0" canBeVaried="1" />
-                      <Parameter id="UOvzTeStFkuWN9EAR6hpdA" name="Geometric surface area" description="Geometric surface area of GI segment" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="9EhmHSAXZ0OXYPaSstfWrQ" visible="1" canBeVaried="1" displayUnit="cm²" />
-                      <Parameter id="K_p5OF_WyEiYltk4_9axCg" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="z9OQBOCK6E2zipk0n2QTMQ" visible="0" canBeVaried="1" displayUnit="1/min" />
-                      <Parameter id="xTmqrMdYvkucrRLSX2tKDQ" name="Length" description="Length" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="oHVl-7jv2UWh9dAin2b_Tg" visible="1" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="-yKg0C0uAUe-1KAy0cvybA" name="Liquid" description="Liquid" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="2aVY-_-FqE6bH8tHqQryGA" visible="0" canBeVaried="1" rHSFormula="pOiAX9pLB0uZgXER87e-WQ" displayUnit="l" />
-                      <Parameter id="X2Anb_VXkUqWkvAwisY8VQ" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="f3gnAjMwYkSqpHnWwnByAg" visible="0" canBeVaried="0" displayUnit="l/min" />
-                      <Parameter id="LCkxywRk1UmJjYjdz-2iDQ" name="Proximal radius" description="Proximal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="qXWNXa9UNUq30PzJeA1etg" visible="1" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="9Q2JYu4WBkK1f5fQS1gl9g" name="Secretion of liquid" description="Rate of liquid inflow" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="5hQhqmmOGke7bHC6ZbrX1g" visible="0" canBeVaried="1" displayUnit="l/min" />
-                      <Parameter id="15-1DTPN-EGTHAqWwMC7zA" name="Thickness of gut wall" description="Thickness of Gut Wall" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="PqZQXUcR2EuAADd5-fG5VQ" visible="0" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="1-ASB6HmsEO9ljEJ8wUH1A" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0060009" />
-                      <Parameter id="QdGkfFdfKUC6ZfqWMG4whg" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0446435379" displayUnit="cm" />
-                      <Parameter id="vccmsdNeIkGiHyov9RKVQA" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.00877" displayUnit="cm" />
-                      <Parameter id="hLVoK4nX4kuGAavJfabp8Q" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.015672726" />
-                      <Parameter id="IwuRZk77lk2olnrXXZGZwg" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.067256381" displayUnit="cm" />
-                      <Parameter id="DOilEaH7skqb2-Jll5eC9w" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.015672726" />
-                      <Parameter id="lyudiZs4AkO2O6oH96DJrQ" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.067256381" displayUnit="cm" />
-                      <Parameter id="DrcZBzgCM0OPHkZ7vkp1Ag" name="Microvilli factor" description="Microvilli factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                      <Parameter id="IDV_YFbqC0a4KJhIo7I3og" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.026864843" />
-                      <Parameter id="LcWEggGcckaKwWj_Mw6aAg" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.1152851235" displayUnit="cm" />
-                      <Parameter id="32w5AIkIdUC5PIW6slsQ0g" name="Intestinal transit rate" description="Transit rate along intestinal segments" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" visible="0" canBeVaried="1" value="18.3333" displayUnit="1/min" />
-                      <Parameter id="neMEW6zLKUqoX0JAiqzUjw" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0897885" displayUnit="1/cm" />
-                      <Parameter id="tEx9Ec7RgUGQ5lYf9vd19g" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="5.7" />
-                      <DistributedParameter id="kSkgmIv-DEubNyE70rL5rw" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="-baRJqE1DUqWtbof0YF_YA" mode="Logical" visible="1">
-                        <Children>
-                          <Parameter id="0C5leecwsUGPcJq7jfcZLw" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                          <Parameter id="AlTDXBbaC0akMJkl-gMfkw" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1.8" />
-                        </Children>
-                      </DistributedParameter>
-                      <MoleculeAmount id="Qnj6YM6q_kSvSvGmWycE8g" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                        <Children>
-                          <Parameter id="z-tvs9pyPEunDjDD-CxpPA" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                          <Parameter id="bKTPNFNwYkm7tnIWA7DBQg" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Z_8QtWZYpkmF7tOvsFbRAA" visible="0" canBeVaried="0" />
-                          <Parameter id="Keo3NR-Mbkiz3TDRfUKAnA" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" visible="0" canBeVaried="0" rHSFormula="_il3MCSTWUiE2lh0y_BsLw" value="0" displayUnit="µmol" />
-                          <Parameter id="CULivekKT0OtuNVr53FyUA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="0" value="1" />
-                          <Parameter id="13ZINrsj7USBW0xRqcBKrQ" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="XN4Nstf-oE6ZK8B6ftJRoA" visible="0" canBeVaried="0" />
-                          <Parameter id="rjD1DjJft0SFhChbV-DdUQ" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="ubFUF91rwEqEt-dhtUno4w" visible="0" canBeVaried="0" />
-                          <Parameter id="ChFfiPhefEWS5jFuA1KF-Q" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="1bolpQyjCUqPJl6YMdn9HA" visible="0" canBeVaried="0" />
-                          <Parameter id="5jEeLC9_hUyLSKQ0SCWaSg" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IHwyL-TOZE2li9aQxl0Ctw" visible="0" canBeVaried="0" />
-                          <Parameter id="rIpQiDtFHEqiIbX6uKtDIw" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="k4Oz6d5fbEOtOd2Z_6DabQ" visible="0" canBeVaried="0" />
-                          <Parameter id="pzo6Kyfuxkufu2G_wzioWg" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="mpNA-y-MbU2hzf6lDcPC6Q" visible="0" canBeVaried="0" />
-                          <Parameter id="oTjyYYrP1UGSx0AopoKGRg" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="U-IxP7womkCOuKD2CjS1Cg" visible="0" canBeVaried="0" />
-                          <Parameter id="M9-vy5CyXEyJkqn9IsCIrA" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="uu0iNyOEXUW76JP4k3aZFg" visible="0" canBeVaried="0" />
-                          <Parameter id="ifzwRxe-f0-DPP9ejNey6w" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="H0sGnbLJZ0mGwSW95-xv4g" visible="0" canBeVaried="0" />
-                          <Parameter id="sAfqE4c7L0aGWghRkC9A0g" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="3siuSAxgbE6O2WDhSdM-xQ" visible="0" canBeVaried="0" />
-                          <Parameter id="YjDbiMlMuEG_YfbVvSHbjw" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="iHU7Psc53UORagpTRLU1zQ" visible="0" canBeVaried="0" />
-                          <Parameter id="Ikm0BtxRTUqley3CGokJXQ" name="Solubility" description="Solubility" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" formula="MJmhdMeuUk2lV8g4IxOHjQ" visible="1" canBeVaried="1" displayUnit="mg/l" />
-                          <Observer id="E-mf9FnuW0O8QM4DVLBH0w" name="Concentration in lumen" description="Concentration of the molecule in lumen" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="HLIRXIitt0KZivKUJbxfRQ" displayUnit="µmol/l" />
-                          <Observer id="lZAmpmIBgkm8n9lbIBDZtw" name="Fraction of oral drug mass absorbed into mucosa segment" description="Fraction of oral drug mass absorbed into mucosa segment" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Drug, Observer" formula="XKRnaHqlW0S6GDKupu_dRA" />
-                        </Children>
-                      </MoleculeAmount>
-                    </Children>
-                  </Container>
-                  <Container id="jhPiKsemqE2D9wuuFrqxsw" name="ColonAscendens" description="Colon Ascendens" icon="ColonAscendens" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Lumen" />
-                      <Tag value="LumenSegment" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="viUBPgP4FUK_3eZBMPCGxg" name="Thickness of gut wall" description="Thickness of Gut Wall" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="PqZQXUcR2EuAADd5-fG5VQ" visible="0" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="nXvIZfckWUqosYWDmm0cIg" name="Absorption of liquid" description="rate of liquid outflow" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="hsbpi7xT1E2clUp4OmI6ag" visible="0" canBeVaried="1" displayUnit="1/min" />
-                      <Parameter id="eGMttTl0V0W0RMJ2L8QViA" name="Distal radius" description="Distal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="F2HrUeP5gUqsHUmUBhdDeQ" visible="1" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="gNmWCuhP9kiQt9cPANSeXw" name="FillLevelFlag" description="Fill Level Flag" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="_fdpBznEC02u7-tLvw5OGQ" visible="0" canBeVaried="1" />
-                      <Parameter id="d2vIMcDAKESuZAHZxEohDQ" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="OyHn7MCeuk6vmTKdv-iJqA" visible="0" canBeVaried="1" />
-                      <Parameter id="3eZlQCE3FkeuXad6xURPSg" name="Geometric surface area" description="Geometric surface area of GI segment" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="9EhmHSAXZ0OXYPaSstfWrQ" visible="1" canBeVaried="1" displayUnit="cm²" />
-                      <Parameter id="NcHuuOAjc0i_fMF1eULoqQ" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="Keua_BuW1k2l_Gge2of7ww" visible="0" canBeVaried="1" displayUnit="1/min" />
-                      <Parameter id="pDdbH7wLa0OvSkn53cBYXQ" name="Length" description="Length" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="oHVl-7jv2UWh9dAin2b_Tg" visible="1" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="YsOTQRKkrESKlbeQkDpmug" name="Liquid" description="Liquid" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="2aVY-_-FqE6bH8tHqQryGA" visible="0" canBeVaried="1" rHSFormula="pE6rnbsnZUWygxN7Qr-xdA" displayUnit="l" />
-                      <Parameter id="niqqv9Bsj0ibrdabvHvGCg" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="V73iJSoFf0KmfHIyK8jajg" visible="0" canBeVaried="0" displayUnit="l/min" />
-                      <Parameter id="Jbwur_7UgUa5N-v5BDkZNg" name="Secretion of liquid" description="Rate of liquid inflow" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="sIvtfRuZGkiGAMEyVUNjKQ" visible="0" canBeVaried="1" displayUnit="l/min" />
-                      <Parameter id="AxsZYrYIVkG-bne9IzqyPg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="cXeVNOGhxUGjgGD8PwjALA" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Parameter id="XYbAu0-Wv0Kz7uG5CPPdIg" name="Volume (gut wall)" description="Volume of the gut wall" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="nCuzY3r2z0eZnR2YrlGvoA" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Parameter id="B-ttu-fJJUSCzoD6i52NGg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="DnUJgRHuPk-8Mncp4a6YGA" name="Proximal radius" description="Proximal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="qXWNXa9UNUq30PzJeA1etg" visible="1" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="VbSJtYtMbE2yT4GFgVjBZw" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.09106073" displayUnit="1/cm" />
-                      <Parameter id="-qYLs4bSjEGvqvawLnA-lg" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0280138174" displayUnit="cm" />
-                      <Parameter id="O565L-KzoEOStOzD_KuVeg" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.00554" displayUnit="cm" />
-                      <Parameter id="FztntaLATUW9uOVtvhb59g" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.067256381" displayUnit="cm" />
-                      <Parameter id="yO6xjHtmukmaQGuA5MSANw" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.015672726" />
-                      <Parameter id="P1pJLTZqpkOLm74ZbCPexg" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.067256381" displayUnit="cm" />
-                      <Parameter id="Wj-BofA-q0WGikbRsvqxnw" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="5.6" />
-                      <Parameter id="z7t-Q1ZK-0SsJY1nbOJwPA" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.015672726" />
-                      <Parameter id="pnjmMeLRbEq0_yrSQQdtNA" name="Microvilli factor" description="Microvilli factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                      <Parameter id="5_816Br5IkGM3HRcx04aew" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.075727844" />
-                      <Parameter id="Q5nhY0loSE-p_1gmjCcvUA" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.3117189273" displayUnit="cm" />
-                      <Parameter id="j4GqQSoM5EWOhLtkLSqtIQ" name="Intestinal transit rate" description="Transit rate along intestinal segments" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" visible="0" canBeVaried="1" value="10" displayUnit="1/min" />
-                      <Parameter id="HKa3-9zVI0ezT-QGqs_9Lw" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0060009" />
-                      <DistributedParameter id="b0k9TcYtYEWXk-d_XuAdPQ" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="AeGMbLE2cUS4irWuGT7unA" mode="Logical" visible="1">
-                        <Children>
-                          <Parameter id="Tj8wBvj9jEyAsIhmsX6HEw" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                          <Parameter id="U2h7w1CoGES0AaxcgBk8Iw" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="2.5" />
-                        </Children>
-                      </DistributedParameter>
-                      <MoleculeAmount id="mgzsCzTwXkGLoEv-ZBAnNQ" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                        <Children>
-                          <Parameter id="NYR44YSrpEu4vR_CKzdRWA" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                          <Parameter id="DkTgs_vot0aPvJK035ihrw" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="b1LiiQ0hskCyDFLoo43Ypw" visible="0" canBeVaried="0" />
-                          <Parameter id="T3AmJ1RlC0unhkO5L2IY9Q" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" visible="0" canBeVaried="0" rHSFormula="jgxVl4G6HUew1s0pFs2YLQ" value="0" displayUnit="µmol" />
-                          <Parameter id="68GtnWD0pE2x76A0X1gqZg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="0" value="1" />
-                          <Parameter id="-tZguRjEbkK74oZJjB2TrQ" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="SW_PRV0KqEqJbLZiAus_lg" visible="0" canBeVaried="0" />
-                          <Parameter id="R_CinLF8mk6luTb55Nag-Q" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="HWSY_xl2AUiWHWGE6V-3jg" visible="0" canBeVaried="0" />
-                          <Parameter id="pom1r-60LEaIIYk5F9fK7g" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Ggw3OrO94U-wZt0r_BUEJg" visible="0" canBeVaried="0" />
-                          <Parameter id="DcZxs4_HfEylmorMM_UYyg" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="8M3ZoeHu_kqyUJbcGPEFuA" visible="0" canBeVaried="0" />
-                          <Parameter id="_UYGnx3FlEqQhPMFKibAng" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="dRgr10eL1UOyec_t1ot7pg" visible="0" canBeVaried="0" />
-                          <Parameter id="tAslZNTfKEiYsBA9zVP2Qg" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="irJBnJOa1Eu1D6iMXnQOZA" visible="0" canBeVaried="0" />
-                          <Parameter id="o16oLB3iC0WxPt_lD7tIJw" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="5qwiI5giNUy5v6RxrdhxXw" visible="0" canBeVaried="0" />
-                          <Parameter id="W2ckH7org0yUYXehngAq5g" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="rwH9RrRW60aNss0oo6CE3Q" visible="0" canBeVaried="0" />
-                          <Parameter id="Vy2D36VEn0m1-_tLt7xtyg" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="HWqOrSLC9k6JpQrAiuBvjQ" visible="0" canBeVaried="0" />
-                          <Parameter id="M-x4DgJ9Hkqg5Dl_zqTdrw" name="Solubility" description="Solubility" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" formula="jRV0gel0lEWesI2wpShosA" visible="1" canBeVaried="1" displayUnit="mg/l" />
-                          <Parameter id="JroOce2YQkuIHKlJGpFVQQ" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="t3_sADOHakqfJmYssd61DQ" visible="0" canBeVaried="0" />
-                          <Parameter id="_VpPYsxkk0-GcpvnlNqazQ" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="iJ74yhoyJE2_i3u1M1Uvlw" visible="0" canBeVaried="0" />
-                          <Observer id="XnRtO9Uob06Kfn8ARYwGrg" name="Concentration in lumen" description="Concentration of the molecule in lumen" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="HLIRXIitt0KZivKUJbxfRQ" displayUnit="µmol/l" />
-                          <Observer id="WNeg8kWzZUa1FtfNcaH9LQ" name="Fraction of oral drug mass absorbed into mucosa segment" description="Fraction of oral drug mass absorbed into mucosa segment" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Drug, Observer" formula="XKRnaHqlW0S6GDKupu_dRA" />
-                        </Children>
-                      </MoleculeAmount>
-                    </Children>
-                  </Container>
-                  <Container id="uB1rpzG6qkapR36UK4VYNQ" name="ColonTransversum" description="Colon Transversum" icon="ColonTransversum" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Lumen" />
-                      <Tag value="LumenSegment" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="jNEEPVxkbU2ePlzqO2Jm8g" name="Length" description="Length" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="oHVl-7jv2UWh9dAin2b_Tg" visible="1" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="sAWg6SmKXk6pC6bp-2sv3g" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="7fdUDwplw0WiOkakEWoWEA" visible="0" canBeVaried="0" displayUnit="l/min" />
-                      <Parameter id="Dy3MqxJZFEKb7019_D_35Q" name="Proximal radius" description="Proximal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="qXWNXa9UNUq30PzJeA1etg" visible="1" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="Q2tNRHcaREuxREsL1iT-rQ" name="Secretion of liquid" description="Rate of liquid inflow" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="6js66GFelUmQLvMVM6oP8w" visible="0" canBeVaried="1" displayUnit="l/min" />
-                      <Parameter id="yFEyRL_wf0inEXGl04QyDA" name="Thickness of gut wall" description="Thickness of Gut Wall" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="PqZQXUcR2EuAADd5-fG5VQ" visible="0" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="uD4hppWaikKWu68AoixnxQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="cXeVNOGhxUGjgGD8PwjALA" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Parameter id="Dcxn0qaLvUmr8dlcgmwxyg" name="Volume (gut wall)" description="Volume of the gut wall" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="y8uL8Z02ZUWxdjoyEPj0Bw" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Parameter id="bum4w5VoCUOGCedPAwNA3Q" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="D6VkGMBZ3EW2acunMU40SA" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="QbA_GGKf80GS1JTZAMtNuA" visible="0" canBeVaried="1" displayUnit="1/min" />
-                      <Parameter id="wlzVcV3wkEKSzjZN4wA7cA" name="Liquid" description="Liquid" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="2aVY-_-FqE6bH8tHqQryGA" visible="0" canBeVaried="1" rHSFormula="0YkdyYjRGUmf7qUM1iVnMQ" displayUnit="l" />
-                      <Parameter id="fgLv5LsNvkO2ZBweWDu5vA" name="Absorption of liquid" description="rate of liquid outflow" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="DGdP-ITmVUeHI6_DPzp-0g" visible="0" canBeVaried="1" displayUnit="1/min" />
-                      <Parameter id="tnoG6c7fhE6x3MFpm-l3BQ" name="Distal radius" description="Distal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="F2HrUeP5gUqsHUmUBhdDeQ" visible="1" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="ZAI6Fu-k3UygZPM-GnxVKg" name="FillLevelFlag" description="Fill Level Flag" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="_fdpBznEC02u7-tLvw5OGQ" visible="0" canBeVaried="1" />
-                      <Parameter id="XiH5iNALrEewkmRWSbZWKA" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="OyHn7MCeuk6vmTKdv-iJqA" visible="0" canBeVaried="1" />
-                      <Parameter id="o33tiAP5REGc6rV0qkx4cw" name="Geometric surface area" description="Geometric surface area of GI segment" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="9EhmHSAXZ0OXYPaSstfWrQ" visible="1" canBeVaried="1" displayUnit="cm²" />
-                      <Parameter id="PKOazY8sukOxaADwkjUnBw" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0060009" />
-                      <Parameter id="y__S3_2JLkmrD3talagKMA" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.6886041141" displayUnit="cm" />
-                      <Parameter id="_40R8pV2-0etYJyB_dAZCA" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0384322177" displayUnit="cm" />
-                      <Parameter id="Q9Xf8WCpg0-BWzQCg6bQhg" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.08637087" displayUnit="1/cm" />
-                      <Parameter id="jFR6o8lDCEqAVAnvq7mvag" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0394956146" displayUnit="cm" />
-                      <Parameter id="DYmlhB-5KU-VKmhEUkiEfA" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0076" displayUnit="cm" />
-                      <Parameter id="xVOYjkvAp0S-Zuwj96OGsA" name="Intestinal transit rate" description="Transit rate along intestinal segments" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" visible="0" canBeVaried="1" value="3.3333" displayUnit="1/min" />
-                      <Parameter id="DboOrsPL-EOkBGgXQ27THQ" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.008955843" />
-                      <Parameter id="C4DJ4VGkpEmeIckYu3O-bw" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.015672726" />
-                      <Parameter id="rHfAC4fA30SV5pAIYWySEw" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.067256381" displayUnit="cm" />
-                      <Parameter id="mG5sjE0APkWnXgpU6UVLAQ" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="5.7" />
-                      <Parameter id="-Fb0Z4SBJ06eBRkkT4b54g" name="Microvilli factor" description="Microvilli factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                      <Parameter id="GVxqBl6rskWlogryGnV-Ow" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.144607745" />
-                      <DistributedParameter id="zXE3zkNXd0eSle_S8Frknw" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="WUCHh7x9b0eyXwH2Zj1VQg" mode="Logical" visible="1">
-                        <Children>
-                          <Parameter id="Zdpa7z_jhEyE-2qd5Qb1Xg" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                          <Parameter id="SUDP3-J_dkObk8FtvYIbEw" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="2.5" />
-                        </Children>
-                      </DistributedParameter>
-                      <MoleculeAmount id="B3i4ajvEPkWwF-QJhPT-RA" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                        <Children>
-                          <Parameter id="9c66-sM9NEejqMcRITIIJQ" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                          <Parameter id="Pi9i5cKxiE6-vKfD4W0-uA" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Q9kDdbKabUqCU8YRbICCFQ" visible="0" canBeVaried="0" />
-                          <Parameter id="OPUd0Ru8n0SOzjb8yfWL2w" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="q2ngvYO4F0aE35RZDOmYhA" visible="0" canBeVaried="0" />
-                          <Parameter id="Fuqpjr48aUyYo2KFaSFyOQ" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IwKGVBSlFE21Zy990gnjlQ" visible="0" canBeVaried="0" />
-                          <Parameter id="3hCsfym3S0GRHhiAWSBvMw" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Q9eqrJvCWEq8nOmcz-ASPg" visible="0" canBeVaried="0" />
-                          <Parameter id="M8UZXqxqWk6RRRSX5JD_Bg" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="V3iIHI8vJUeND9mEeb86IA" visible="0" canBeVaried="0" />
-                          <Parameter id="ptXXTZtN_kW7DDHdLQXCaA" name="Solubility" description="Solubility" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" formula="Lfbs-GRlGE6rThSBKfltmA" visible="1" canBeVaried="1" displayUnit="mg/l" />
-                          <Parameter id="DiNIDiaAmE2JQriAZmdG9A" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="S9NYSx9sCky5bOpOKmGBpA" visible="0" canBeVaried="0" />
-                          <Parameter id="n1y2IqEQ8kGpCCO2b0JLqw" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="KA242Rj6pUO9r6mghCA2Gw" visible="0" canBeVaried="0" />
-                          <Parameter id="wioYh6s10k6zSSYEImDpSg" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="XPQ_zkSV-E-P6CCOCOPKXQ" visible="0" canBeVaried="0" />
-                          <Parameter id="DKaFclPE-USexNiwawLGzg" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Oc8ZKRbYKUSas4YeW5s05Q" visible="0" canBeVaried="0" />
-                          <Parameter id="D02-fSSDQEaWHiuHBMnrhQ" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" visible="0" canBeVaried="0" rHSFormula="G8mRjslt9Uqc-waxWogQ8Q" value="0" displayUnit="µmol" />
-                          <Parameter id="4r3rO6rJ8UumIsHnhZmBTA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="0" value="1" />
-                          <Parameter id="KjNIeyvXtE-5xdH5Hih-Ug" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="4ZnAyRse80mPg9gopNYdMQ" visible="0" canBeVaried="0" />
-                          <Parameter id="ozaik5pDsEyc8ehRJnnWIw" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="yUOCf5_22EC69VdC3J-FVA" visible="0" canBeVaried="0" />
-                          <Parameter id="QO_Km-1tVUe6RaoJ5oU-kA" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="NOxJMq20mkS0ZLthD0EjMA" visible="0" canBeVaried="0" />
-                          <Observer id="hslvxNXcE0ef5wYbo9yoKg" name="Concentration in lumen" description="Concentration of the molecule in lumen" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="HLIRXIitt0KZivKUJbxfRQ" displayUnit="µmol/l" />
-                          <Observer id="Xq8JxZzhFUqDSA9xlRmEtw" name="Fraction of oral drug mass absorbed into mucosa segment" description="Fraction of oral drug mass absorbed into mucosa segment" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Drug, Observer" formula="XKRnaHqlW0S6GDKupu_dRA" />
-                        </Children>
-                      </MoleculeAmount>
-                    </Children>
-                  </Container>
-                  <Container id="Tizt5eh3cUGAxWKaiYKVQw" name="ColonDescendens" description="Colon Descendens / Distal Colon 1" icon="ColonDescendens" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Lumen" />
-                      <Tag value="LumenSegment" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="XYoe-kxC0kaI3muOqMG6tA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="eoVfC5mgMkizifUbhy-FjQ" name="FillLevelFlag" description="Fill Level Flag" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="_fdpBznEC02u7-tLvw5OGQ" visible="0" canBeVaried="1" />
-                      <Parameter id="_u9Qu1OuIUeLwDtxdJ832g" name="Volume (gut wall)" description="Volume of the gut wall" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="u5ojFsBtEkm-beiLO4vDoQ" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Parameter id="5yFrg5ufv0yefLnP-5V1Ng" name="Distal radius" description="Distal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="F2HrUeP5gUqsHUmUBhdDeQ" visible="1" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="i1ekRF8LO0C7obBPe44OdA" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="OyHn7MCeuk6vmTKdv-iJqA" visible="0" canBeVaried="1" />
-                      <Parameter id="Vd-vzBcUBkaz2ayhL8QWpg" name="Geometric surface area" description="Geometric surface area of GI segment" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="9EhmHSAXZ0OXYPaSstfWrQ" visible="1" canBeVaried="1" displayUnit="cm²" />
-                      <Parameter id="kZppsGdyyU-wO6LjXUceNw" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="PWQzN2eIlESR-tMyGqGAag" visible="0" canBeVaried="1" displayUnit="1/min" />
-                      <Parameter id="90dShX49bk6U71PBC5DNGQ" name="Length" description="Length" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="oHVl-7jv2UWh9dAin2b_Tg" visible="1" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="yLEWhm3bQEmjjGb4QwFAKA" name="Liquid" description="Liquid" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="2aVY-_-FqE6bH8tHqQryGA" visible="0" canBeVaried="1" rHSFormula="iueu9e24tU6khEDO0Vzp3g" displayUnit="l" />
-                      <Parameter id="MlqGkvwkG0SRMuV4N2cTTg" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="vu-Ba5lRpUSOjziCwL-4GQ" visible="0" canBeVaried="0" displayUnit="l/min" />
-                      <Parameter id="VA2hfWcf2EuumsV0CCQv4g" name="Proximal radius" description="Proximal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="qXWNXa9UNUq30PzJeA1etg" visible="1" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="KoE2onFqkkC2IuKURAKLSw" name="Secretion of liquid" description="Rate of liquid inflow" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="z5f4Mbfsj0u0sDsk5aYOkw" visible="0" canBeVaried="1" displayUnit="l/min" />
-                      <Parameter id="QwdkxYEifEib5359jWWVNQ" name="Thickness of gut wall" description="Thickness of Gut Wall" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="PqZQXUcR2EuAADd5-fG5VQ" visible="0" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="KSkAAnA4F0Gsdp7rZlCxyQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="cXeVNOGhxUGjgGD8PwjALA" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Parameter id="A8htP2cxkUSvIuMBXBx8Rg" name="Absorption of liquid" description="rate of liquid outflow" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="DJ5wJfvnZEOiN86L1zgO7w" visible="0" canBeVaried="1" displayUnit="1/min" />
-                      <Parameter id="m6PlogT2mUC_4yikuXDS_w" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0384322177" displayUnit="cm" />
-                      <Parameter id="EBlTTE1Tn0mUmAfjs3djug" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.008955843" />
-                      <Parameter id="440OlT3N-06cmw8f_CNYjQ" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0384322177" displayUnit="cm" />
-                      <Parameter id="VDGEkpclpk6mSS7CoMf1_A" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="6.6" />
-                      <Parameter id="ox3-7b20ekue6IYzFrirrQ" name="Microvilli factor" description="Microvilli factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                      <Parameter id="XgaSzOpRPUCrvGAo8UtNxQ" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.098514277" />
-                      <Parameter id="HVU2NIN99Ea9uXbE8SVtvg" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.4227543951" displayUnit="cm" />
-                      <Parameter id="4A9DPxWwmUiPpaXaj-G3Kg" name="Intestinal transit rate" description="Transit rate along intestinal segments" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" visible="0" canBeVaried="1" value="5" displayUnit="1/min" />
-                      <Parameter id="pzSvjbgjIEOwi9eFRQWXbg" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.008955843" />
-                      <Parameter id="7LdDP8PDMEeTFsXm1GC2Gg" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.08977747" displayUnit="1/cm" />
-                      <Parameter id="muI5H60zkEuZaDvgYPZmRw" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0601543776" displayUnit="cm" />
-                      <Parameter id="4aXOpZk4J0ewsz6l4mB_Ig" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0118" displayUnit="cm" />
-                      <Parameter id="W70_HD5JLE-z-h9ixFE5jQ" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0060009" />
-                      <DistributedParameter id="S93xmEnP20WSwHiWtzThXQ" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="4d_tSWwpMEWOUqfVXqOSSw" mode="Logical" visible="1">
-                        <Children>
-                          <Parameter id="nVHGtCbXLUOnVOU6g7BZZw" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                          <Parameter id="BEsp2Zlzok2KnRXIcXSx6w" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="2.5" />
-                        </Children>
-                      </DistributedParameter>
-                      <MoleculeAmount id="yiZ323gtz0WRt_37u8tDPQ" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                        <Children>
-                          <Parameter id="-RNo_u2RLUiPrateHg-bsQ" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                          <Parameter id="8SGLOlxhnEiIQgXq7suTQQ" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="5SmaX5z-v0On9zuR6oIO4w" visible="0" canBeVaried="0" />
-                          <Parameter id="huScLJAkm0--QG0yrFVFNg" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="sqZulsxJqUiHCvvlJ_eqFQ" visible="0" canBeVaried="0" />
-                          <Parameter id="2eICo8mlwEGa2TIoVTfi_Q" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="tAvMptOyqUWokQ-Ft9Ynrw" visible="0" canBeVaried="0" />
-                          <Parameter id="T1EaA5qTy0i2KNa16vAz5Q" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="joKIuwHXqEeNGZD1Dgg7dw" visible="0" canBeVaried="0" />
-                          <Parameter id="NyX-sTnwoUyxnjRBFLTOHA" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="X3-_AUN2Ukadv7469fGvkg" visible="0" canBeVaried="0" />
-                          <Parameter id="vG4TOZF13EKLkbNGSeQB_g" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="wr-g10h8YEa8K25XS38bHw" visible="0" canBeVaried="0" />
-                          <Parameter id="7IfcN_KBU0-AnZ-skek1Hw" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="O4uXq9fcQUOOjOIOSBebzQ" visible="0" canBeVaried="0" />
-                          <Parameter id="lUCAZGyWLkmwiZ6kzkbqzQ" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="8a_4Ku7qeU2ET4MTsuq1eg" visible="0" canBeVaried="0" />
-                          <Parameter id="qKoNYPvx_EO20e99k-obGQ" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" visible="0" canBeVaried="0" rHSFormula="tk4SCA3cmUqcJk5RnR57SQ" value="0" displayUnit="µmol" />
-                          <Parameter id="wfL15SOB9U6kwyPk0NLKmQ" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="YPcDU6OflUK1GsshCttR_g" visible="0" canBeVaried="0" />
-                          <Parameter id="V6Crg7NRVEWMwL-pAp6phw" name="Solubility" description="Solubility" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" formula="dmsldFy_d0yxW1F99kczwg" visible="1" canBeVaried="1" displayUnit="mg/l" />
-                          <Parameter id="7SOo0kgdJkCXaS685B0sSw" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="1mqdNKpEUkyjrQ2u-b6LhQ" visible="0" canBeVaried="0" />
-                          <Parameter id="UtX1UHM_e0CcpoSE24NwUw" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="q9ONV7JhAUmz3JIZXXMtaQ" visible="0" canBeVaried="0" />
-                          <Parameter id="_L8PbaL4Gkiq52IONSzWSQ" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="MzLD1RbN0E2gWRS1tXcKXQ" visible="0" canBeVaried="0" />
-                          <Parameter id="LdYSyRh36km392IQvqIszw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="0" value="1" />
-                          <Observer id="DpY4ynQhPU-vzbVoPDEEDQ" name="Concentration in lumen" description="Concentration of the molecule in lumen" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="HLIRXIitt0KZivKUJbxfRQ" displayUnit="µmol/l" />
-                          <Observer id="EtocigzBh0K_ZSX_DnqoUg" name="Fraction of oral drug mass absorbed into mucosa segment" description="Fraction of oral drug mass absorbed into mucosa segment" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Drug, Observer" formula="XKRnaHqlW0S6GDKupu_dRA" />
-                        </Children>
-                      </MoleculeAmount>
-                    </Children>
-                  </Container>
-                  <Container id="FF0ppGi5GkaCMtFrfbD1kA" name="ColonSigmoid" description="Colon Sigmoid / Distal Colon 2" icon="ColonSigmoid" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Lumen" />
-                      <Tag value="LumenSegment" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="dKuhR2z62EWOCHGQLT0Nkg" name="Thickness of gut wall" description="Thickness of Gut Wall" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="PqZQXUcR2EuAADd5-fG5VQ" visible="0" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="drJ5GAV8okS01DM-TLYRfA" name="Absorption of liquid" description="rate of liquid outflow" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="raaPAu1fU0iAAnp-w64zew" visible="0" canBeVaried="1" displayUnit="1/min" />
-                      <Parameter id="_ArH5UcUxUOW2jtMAcwDhA" name="Distal radius" description="Distal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="F2HrUeP5gUqsHUmUBhdDeQ" visible="1" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="JcY2ZiWG4kmwbniZIZW9fA" name="FillLevelFlag" description="Fill Level Flag" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="_fdpBznEC02u7-tLvw5OGQ" visible="0" canBeVaried="1" />
-                      <Parameter id="b0PgUCHK6k-E3VQum90NAA" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="OyHn7MCeuk6vmTKdv-iJqA" visible="0" canBeVaried="1" />
-                      <Parameter id="WXI47IgDTU-Ig2QXR6Nsiw" name="Geometric surface area" description="Geometric surface area of GI segment" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="9EhmHSAXZ0OXYPaSstfWrQ" visible="1" canBeVaried="1" displayUnit="cm²" />
-                      <Parameter id="S95lUJnsvU-D4NB3v6PnQg" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="h5T7bksqM06EslDPAaJ2WA" visible="0" canBeVaried="1" displayUnit="1/min" />
-                      <Parameter id="T_FdVPra90WtwrcmpG2NMQ" name="Length" description="Length" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="oHVl-7jv2UWh9dAin2b_Tg" visible="1" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="1O7kPmcjGE-kXhs0uZNgrQ" name="Liquid" description="Liquid" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="2aVY-_-FqE6bH8tHqQryGA" visible="0" canBeVaried="1" rHSFormula="M8B1FjdsN06uE0D4iKM36w" displayUnit="l" />
-                      <Parameter id="P28P6FamjEatgwwBuQcUUg" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="iBhnMkyDG02aBOWLVQkpnQ" visible="0" canBeVaried="0" displayUnit="l/min" />
-                      <Parameter id="LG08Tm_Vzkq8qAwLpsAs7A" name="Proximal radius" description="Proximal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="qXWNXa9UNUq30PzJeA1etg" visible="1" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="aYvWgr_OpUKC3DPZI0W9wA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="cXeVNOGhxUGjgGD8PwjALA" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Parameter id="gCsBFfjOT06NmFBdPDplEg" name="Volume (gut wall)" description="Volume of the gut wall" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="GevFGp6Z5UaiGEpJ99y0bg" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Parameter id="dmxA9RkRT0q3GZGoLIs75w" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="4zDI9Pf-X0CuhIbN_Sob5g" name="Secretion of liquid" description="Rate of liquid inflow" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="jq52RNCp9E6CRl075YyMbQ" visible="0" canBeVaried="1" displayUnit="l/min" />
-                      <Parameter id="AEkoCvP59k-m7fbb6mGhWA" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0384322177" displayUnit="cm" />
-                      <Parameter id="Gu3gypUEAkWlMJVKvjpCbQ" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0889014" displayUnit="1/cm" />
-                      <Parameter id="jJfRDxeyHkK9Jribd0d2TA" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0274432593" displayUnit="cm" />
-                      <Parameter id="-pIAk0o6kUa4C4szwob30g" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.00536" displayUnit="cm" />
-                      <Parameter id="lxhezwRw9EOpOvySIGlGXw" name="Intestinal transit rate" description="Transit rate along intestinal segments" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" visible="0" canBeVaried="1" value="4.0741" displayUnit="1/min" />
-                      <Parameter id="iw9RZb8fRUOZx8144HPI2w" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.008955843" />
-                      <Parameter id="_8U7c9gF20K_TNFozzp3XA" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0384322177" displayUnit="cm" />
-                      <Parameter id="pBejKZ0JmkCjkSeWmWZhxg" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="6.6" />
-                      <Parameter id="QHDzv3Gt8EqmPIKSzd6i7w" name="Microvilli factor" description="Microvilli factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                      <Parameter id="RUzqP_PeDUehbL20fEjNKA" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.121300709" />
-                      <Parameter id="41CDMkq7bEO2gQe-A4wfDw" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.008955843" />
-                      <Parameter id="SwnCnI7YvkelDnXBCl1NLQ" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5337898629" displayUnit="cm" />
-                      <Parameter id="FtMo2B0MakaJ3crXIVk4yQ" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0060009" />
-                      <DistributedParameter id="WBmWWAzZ6ku0V6KyLUCY3Q" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="fQ_fmAtHu0-4pi9fov9Obg" mode="Logical" visible="1">
-                        <Children>
-                          <Parameter id="0JHaGevkxUygvc36LHDmdA" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                          <Parameter id="sKXqM6nsZ0C6nJamIlfqog" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="2.5" />
-                        </Children>
-                      </DistributedParameter>
-                      <MoleculeAmount id="jIGCgtwn-U2Oqcv2W4G-ZQ" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                        <Children>
-                          <Parameter id="jhNY2CQ7qE-2Ew3N67PteQ" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                          <Parameter id="vSGCDoUwVkehmiDU1quE8A" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="vCrIzy5_1ESqvBhRLXpF5w" visible="0" canBeVaried="0" />
-                          <Parameter id="cchXTpVP3k-bQulnflivUA" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="aaN0oRlL0UqJCGPBHAdxDw" visible="0" canBeVaried="0" />
-                          <Parameter id="5EE7ZEXQnEitZeaaGKdVcQ" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="jqOKh9IlDUuPjU07LUJpfw" visible="0" canBeVaried="0" />
-                          <Parameter id="x3999iR1wkCiCg4ywNYv4g" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="K51DMgiyp0O_ti_JBCqZiA" visible="0" canBeVaried="0" />
-                          <Parameter id="HpSfxMfzPUmXd8cES5iryg" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="vWnVVEuk10u2Oc9kqs8o2g" visible="0" canBeVaried="0" />
-                          <Parameter id="MbFIiM6SkU29YISXcnnkOA" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="GNl4uLnLQUSCNrBQn2GtTg" visible="0" canBeVaried="0" />
-                          <Parameter id="NwK0RFDGmku79Qt7fKg3gQ" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="uVhmAX8O90GvrGE-UBfiUQ" visible="0" canBeVaried="0" />
-                          <Parameter id="YqeBEfNTWEe54pG1t87_EQ" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="dnS4R2rmakujlz83K7Y7zg" visible="0" canBeVaried="0" />
-                          <Parameter id="vusN9vdFYEWieIFC8Cz2zg" name="Solubility" description="Solubility" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" formula="iEysIT7pcEGHRyJCNrRRMQ" visible="1" canBeVaried="1" displayUnit="mg/l" />
-                          <Parameter id="WDCUDQg7VkW1lyB6awvbHw" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IRp0ios9aEexciHVsGsvnQ" visible="0" canBeVaried="0" />
-                          <Parameter id="Gijf6NcUBEK7SHmpA9tFXQ" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="2J5XUvx2dEWLL2V6an6ztg" visible="0" canBeVaried="0" />
-                          <Parameter id="7ayfcuRetkOSt13WJfvtSw" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="qz67lpAOAE6kLKaQJsJyKQ" visible="0" canBeVaried="0" />
-                          <Parameter id="oLYAyxbcSUKThuiBC0gjHA" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" visible="0" canBeVaried="0" rHSFormula="2W0GQs4Ki0Kh34mPKysMOg" value="0" displayUnit="µmol" />
-                          <Parameter id="wPSDxr8HgE6U0F2L5yDljQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="0" value="1" />
-                          <Parameter id="CupTlPWILkO1kDHOtsGuMQ" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="-Iqdttfh00GvQTYfUseLhA" visible="0" canBeVaried="0" />
-                          <Observer id="o8NlG7Y0RkaLuPYPph25GA" name="Concentration in lumen" description="Concentration of the molecule in lumen" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="HLIRXIitt0KZivKUJbxfRQ" displayUnit="µmol/l" />
-                          <Observer id="WukqIbmbQUq1Awn7RG2Y1Q" name="Fraction of oral drug mass absorbed into mucosa segment" description="Fraction of oral drug mass absorbed into mucosa segment" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Drug, Observer" formula="XKRnaHqlW0S6GDKupu_dRA" />
-                        </Children>
-                      </MoleculeAmount>
-                    </Children>
-                  </Container>
-                  <Container id="eprwABQUEkOQApydkOYKug" name="Rectum" description="Rectum" icon="Rectum" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Lumen" />
-                      <Tag value="LumenSegment" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="FahMX3bmukGp8avTD38Ymw" name="Length" description="Length" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="oHVl-7jv2UWh9dAin2b_Tg" visible="1" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="D4VtC_GPt0ilv4sJ6gihzg" name="Absorption of liquid" description="rate of liquid outflow" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="OkubLRgciUe2vrc8xQTUHA" visible="0" canBeVaried="1" displayUnit="1/min" />
-                      <Parameter id="s3HnxPcx4UmyuqH6BWELOg" name="Distal radius" description="Distal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="F2HrUeP5gUqsHUmUBhdDeQ" visible="1" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="j4gZ5CjG8EuvZ9EQwgQhMA" name="FillLevelFlag" description="Fill Level Flag" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="_fdpBznEC02u7-tLvw5OGQ" visible="0" canBeVaried="1" />
-                      <Parameter id="MvL5YrO5Jk-bZa2nR5L6mQ" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="OyHn7MCeuk6vmTKdv-iJqA" visible="0" canBeVaried="1" />
-                      <Parameter id="BPsX9RL8MECAX_C-0fEPBA" name="Geometric surface area" description="Geometric surface area of GI segment" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="9EhmHSAXZ0OXYPaSstfWrQ" visible="1" canBeVaried="1" displayUnit="cm²" />
-                      <Parameter id="SmVapyFxAE2cZukA06R-YQ" name="Liquid" description="Liquid" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="2aVY-_-FqE6bH8tHqQryGA" visible="0" canBeVaried="1" rHSFormula="LVKmAVLS3kyx6PYjgl2laQ" displayUnit="l" />
-                      <Parameter id="Dz9zpRl5AUqoJMwfdPMxUw" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="8Zf7paM7GEqDexdM2sLUsg" visible="0" canBeVaried="1" displayUnit="1/min" />
-                      <Parameter id="OiXoq9xitEaVymZDZr1SHw" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Zgl8t2xXbkagziKqPp0F1Q" visible="0" canBeVaried="0" displayUnit="l/min" />
-                      <Parameter id="WgaRMvU_PU2GkxwDHwYrsg" name="Proximal radius" description="Proximal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="qXWNXa9UNUq30PzJeA1etg" visible="1" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="k_0xd1R48UOcraB3dMXbzg" name="Secretion of liquid" description="Rate of liquid inflow" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Nw59eaXM8EmeT6fOWisWXQ" visible="0" canBeVaried="1" displayUnit="l/min" />
-                      <Parameter id="1Km4-YXNbkS1WMpJD8LTZQ" name="Thickness of gut wall" description="Thickness of Gut Wall" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="PqZQXUcR2EuAADd5-fG5VQ" visible="0" canBeVaried="1" displayUnit="cm" />
-                      <Parameter id="TK1RCKE4vk6N3G9A6uwmXw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="cXeVNOGhxUGjgGD8PwjALA" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Parameter id="eME_d88Zz06oOfED4VFrDw" name="Volume (gut wall)" description="Volume of the gut wall" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="AFLVjEqIMU60X67nq3PZaQ" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Parameter id="P15bPF7_BkCJBNGgK5Rozw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="UZSrwxoVjUmtv0SU4f_3Ww" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0060009" />
-                      <Parameter id="Ej8bEDRle0GtPorZg_FQdw" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0324721331" displayUnit="cm" />
-                      <Parameter id="0UjwLbjNjkCrKtGVgxYOFw" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.00665" displayUnit="cm" />
-                      <Parameter id="HefeOmAol0SlobO6k9XhBw" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.005597402" />
-                      <Parameter id="AFvYLprKJE6IfdOmNn5XTA" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0240201361" displayUnit="cm" />
-                      <Parameter id="_1xJmz82Dk-C_3Afl8mhUQ" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.008955843" />
-                      <Parameter id="pOPcAMRcz06XrtM_GGc0TQ" name="Intestinal transit rate" description="Transit rate along intestinal segments" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" visible="0" canBeVaried="1" value="315.618" displayUnit="1/min" />
-                      <Parameter id="Qi-3tPgEtkCH4cN1fXj5_Q" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.1569046761" displayUnit="cm" />
-                      <Parameter id="ihq-qNM3EEiYmMlExyE_5w" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="6.6" />
-                      <Parameter id="tycU23bIikGzv3xD6WroXQ" name="Microvilli factor" description="Microvilli factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                      <Parameter id="6Kmt5PoE-UO8shzIrof8aQ" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.052420808" />
-                      <Parameter id="eqTWpICfJEi-Y2t6H9gN2g" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0384322177" displayUnit="cm" />
-                      <Parameter id="JxUQMgK5OEOsr3kilJ1hKg" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.10014267" displayUnit="1/cm" />
-                      <DistributedParameter id="tdrm3008BkCsYfxN0Q5CHA" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="bW0caNHwPE6bBQPsJKXbHw" mode="Logical" visible="1">
-                        <Children>
-                          <Parameter id="zm0Kn8luAUKkU89ddUwg9w" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                          <Parameter id="fKaEC3XwY0iAKz-XZqcahQ" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="3.56" />
-                        </Children>
-                      </DistributedParameter>
-                      <MoleculeAmount id="2kdpKYdY3EeBvJPRNS1TEg" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                        <Children>
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-                          <Parameter id="E_0z0GLADEaJoWyzizyYMQ" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" visible="0" canBeVaried="0" rHSFormula="eCNj3MGCBEGCC0nhjiAtHA" value="0" displayUnit="µmol" />
-                          <Parameter id="p6f6SevTEEOZAZe9pv0AJQ" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="HMWrXvoT3kWsXDm0zf_q5Q" visible="0" canBeVaried="0" />
-                          <Parameter id="TPwhhRFSqkeVHNgH_iqtZA" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="lNQIrs-5UUmtEexY-1b-0A" visible="0" canBeVaried="0" />
-                          <Parameter id="lGuGXv-K3Uq85NEKyAhpzA" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="uIBkAdyujU60-QX3lyPGtw" visible="0" canBeVaried="0" />
-                          <Parameter id="lb7HARi3YU6D2_2JbqPMOw" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="o3P3Evx3Y0abEPPGp6n5lA" visible="0" canBeVaried="0" />
-                          <Parameter id="mwEBahufakaiumVsRLH8rw" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Ggh_jGKflk2w3FlpgCwW9w" visible="0" canBeVaried="0" />
-                          <Parameter id="X_cLAtDnCk6FVAlallAGug" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="eqTHTeezfk2KS_9y10vH3w" visible="0" canBeVaried="0" />
-                          <Parameter id="yfRRRPZdFEuGW7AE8jm94Q" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="AAjrdnlysUehsM8CRxXN_A" visible="0" canBeVaried="0" />
-                          <Parameter id="_YZ-8nVuOU-rAEE1GlLkyQ" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="fgkcbOf4pkWdjtjOQKF2Gw" visible="0" canBeVaried="0" />
-                          <Parameter id="UHLSYFf6LkySV1JFEcxnng" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="daIx8UNeRUWs1kDNBzCufQ" visible="0" canBeVaried="0" />
-                          <Parameter id="Vt2UEovxLE-WkByUwh2QcQ" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Bb32SDfj6ka88Bp0I8jZZA" visible="0" canBeVaried="0" />
-                          <Parameter id="UctLCgYcFECpgImusIiyuA" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="SuX8N0IGOEmDia5VOBtLhQ" visible="0" canBeVaried="0" />
-                          <Parameter id="GvJvPT_ZQ0GUgYJAEDNU_g" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="TsRo45A9iUWUlN00TRmT1A" visible="0" canBeVaried="0" />
-                          <Parameter id="PEIodOI7DkGJvTwdHrimIA" name="Solubility" description="Solubility" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" formula="S_LulL1ig0KPBgGaPL0Hfw" visible="1" canBeVaried="1" displayUnit="mg/l" />
-                          <Parameter id="iIP41J6E0UivZgjVZ09hMg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="0" value="1" />
-                          <Observer id="Sw6TsOz01E2kXZOK6ctDFA" name="Concentration in lumen" description="Concentration of the molecule in lumen" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="HLIRXIitt0KZivKUJbxfRQ" displayUnit="µmol/l" />
-                          <Observer id="OFmjPYzLQEuh0om3M2Em_w" name="Fraction of oral drug mass absorbed into mucosa segment" description="Fraction of oral drug mass absorbed into mucosa segment" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Drug, Observer" formula="XKRnaHqlW0S6GDKupu_dRA" />
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-                    <Tags>
-                      <Tag value="Lumen" />
-                      <Tag value="LumenSegment" />
-                    </Tags>
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-                        <Children>
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-                      <Observer id="RwAAFNK-mUyU7kOF0VFoBg" name="Fraction of oral drug mass absorbed into mucosa" description="Fraction of oral drug mass absorbed into mucosa" persistable="1" isFixedValue="0" dim="Fraction" quantityType="Drug, Observer" formula="HJpEilfGvUWWOhQMQNbNHQ" />
-                    </Children>
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-                </Children>
-              </Container>
-              <Container id="Ye7ydHvGlUCivOdhatm4Dw" name="Stomach" description="Stomach" icon="Stomach" mode="Logical" containerType="Organ">
-                <Tags>
-                  <Tag value="Portal Vein Supplying Organ" />
-                  <Tag value="TissueOrgan" />
-                </Tags>
-                <Children>
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-                  <Parameter id="sX7Bpv-daUS55PRxKYV93A" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CBHG2JXCvUaDcO6ZoidROA" visible="1" canBeVaried="0" displayUnit="l" />
-                  <Parameter id="-9LoKh9C3Uie6KZijC1A_Q" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="irnuxqjV80Kt6IZmjMD02g" visible="1" canBeVaried="1" displayUnit="l/min" />
-                  <Parameter id="KccI3g0NpUq1cKrfasGm5g" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="NMJACUQWYkOxmQ9OpiZ5Kg" visible="1" canBeVaried="1" displayUnit="l/min" />
-                  <Parameter id="QWpRweUMwU6haE5eCchplQ" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="LSHvGCmOBEascdPo-Ab-KQ" visible="1" canBeVaried="1" />
-                  <Parameter id="DqsHdBHjv0a7fAVMD-Wm1Q" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="jdhhCNoMYE-s118HG9XzZw" visible="1" canBeVaried="1" displayUnit="l/min" />
-                  <Parameter id="1wg2ZYgg80KPerfANuHqvQ" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                  <Parameter id="X1BaqFBOyUWOxMVhww_CRQ" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.75" />
-                  <Parameter id="0e6lGRW-T0WtUyDU_ApPUg" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                  <Parameter id="YjgTmciRM0eaafhfLhwf8A" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="4.5E-08" displayUnit="µm" />
-                  <Parameter id="oAW31AnlAkO1ETxmeNO55A" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="2.5E-07" displayUnit="µm" />
-                  <Parameter id="MKm0SkjCeU-TRBznvTNL6w" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" visible="1" canBeVaried="1" value="3.97222222222222E-11" displayUnit="ml/min/N" />
-                  <Parameter id="DDEMkCrHRUWLLibzTRXNRg" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.05" />
-                  <Parameter id="8x9dbMaRMUSrRq320vgBvQ" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0487" />
-                  <Parameter id="5JXyUO8HCkKLDC9l3-NdgQ" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.062" />
-                  <Parameter id="TVU9jV-Ve0qTcYvmP87-VQ" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.032" />
-                  <Parameter id="3iRY9zlJm0K4oLQ8kaMNrg" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.133" />
-                  <Parameter id="egd2Om5XvE2D_2819JnWrw" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0163" />
-                  <Parameter id="K8eqQC8huE64Ot2tqPBcPQ" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.718" />
-                  <Parameter id="aW6MvItOqU6_iJWyoR4XXQ" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.792" />
-                  <Parameter id="3vcHfJFALEKmIAeEKFlYHg" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.158" />
-                  <Parameter id="kMLFoB_UD0qlLM-SghC7mg" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.141" />
-                  <Parameter id="3T0RLTtzXUSK9DcFffxSHw" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
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-                  <Parameter id="7xMuH4fmYk6iwyyfAD_vZw" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0124" />
-                  <Parameter id="cOrwAZsfcUeJM0L6XglfIQ" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.282" />
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-                  <Parameter id="8UXrqfYhCEGMTFIs9DeB3Q" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0035" />
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-                    <Children>
-                      <Parameter id="J7zWPdI8HEy6Z5qKmQLvLw" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.500397173769471" displayUnit="l" />
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-                    </Children>
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-                    <Children>
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-                    <Tags>
-                      <Tag value="Portal Vein Supplying Organ" />
-                      <Tag value="Stomach" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="yOelcv9t0kCeiAW3cq8Rlg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="7yQUuRlEDUOwUcAfuDoj7A" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="AWSLB9BqIUm588s01h4uMw" visible="1" canBeVaried="1" displayUnit="l" />
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-                        <Children>
-                          <Parameter id="uhFb-8q9C0mpvMFBAYgqAg" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                          <Parameter id="1s39vJvBVk-FepDVLmXFcQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="MGs4CPUlv0un5ELapLsOog" visible="0" canBeVaried="0" />
-                          <Observer id="57mHw7X3MUWd70_qb_RcnA" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
-                        </Children>
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-                  </Container>
-                  <Container id="J3KHzmzoG0ybBAX8Q-IY2w" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Portal Vein Supplying Organ" />
-                      <Tag value="Stomach" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="Iwpa-maRAkqykklv3Bzjdg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="Jds6vTOj3kSVoHgVf_m3ow" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="bFSKBq9P6ESwCQ7kJZpF0A" visible="1" canBeVaried="1" displayUnit="l" />
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-                          <Parameter id="bk_Xds2A_kupkXuQY-mPxA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="ZIbqwTbAaECs871WD7m-cQ" visible="0" canBeVaried="0" />
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-                        </Children>
-                      </MoleculeAmount>
-                    </Children>
-                  </Container>
-                  <Container id="BO_2kdQ94EefqAdvRA1T2Q" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Portal Vein Supplying Organ" />
-                      <Tag value="SmallIntestine" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="08MvwQEvakmXNOej6Dr2rQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="J8SSHZ7iHU-Ny6Ffw0dWOQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="iiR-BhU-e0i9WlcPjQsNdg" visible="1" canBeVaried="1" displayUnit="l" />
-                      <MoleculeAmount id="gACrDjDg5UuEdDtbqzvxDA" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                        <Children>
-                          <Parameter id="MhcHcMBJvkiAly1Q45ptfg" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                          <Parameter id="C7cLg20RZUCiXwtzDIfA-g" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="_TUFkae23ES3UIEj8Fcp9w" visible="0" canBeVaried="0" />
-                          <Observer id="1YGacwcXnUuHYGjx-BsRdA" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
-                        </Children>
-                      </MoleculeAmount>
-                    </Children>
-                  </Container>
-                  <Container id="ilLnP1DOPkuzNEpG7Fv3Lg" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Portal Vein Supplying Organ" />
-                      <Tag value="SmallIntestine" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="xlqq8MsSoEiZsjbuLQtoyQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="YadSD5ncukGvfMUU88mX6g" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="8PysAt2r-Uuae7YiFGiTNQ" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Parameter id="j5s7X_seokSQ8QH1CUnUwQ" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="mmPlMPjMnECVqmG5mkXJMw" visible="1" canBeVaried="1" />
-                      <MoleculeAmount id="fclzk6VWh02b904j5Lzyow" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                        <Children>
-                          <Parameter id="S6GvzJWx80KZZPDx2yx61g" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                          <Parameter id="yZw44ZddH0OeRxQ0tkfdvg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="u_vIomo5MEK8iZ9FLpyKPQ" visible="0" canBeVaried="0" />
-                          <Observer id="sisTFiR8ykysSq6Dh7jRqA" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
-                        </Children>
-                      </MoleculeAmount>
-                    </Children>
-                  </Container>
-                  <Container id="OHqsp3isJUGXVMaVk0iHQg" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="Portal Vein Supplying Organ" />
-                      <Tag value="SmallIntestine" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="hZxkoAjNFUm9F2PxnhsS8g" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="YcDySoEECUCkabMfcgVuzw" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="vZFoq2eOvkSRqULXh96lvw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="Ue-GxIfM90qPHZMmN2fUlw" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Parameter id="Hed2JzeHx0KTlwrJNZnHJw" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.4" />
-                      <MoleculeAmount id="HO6kTUalu0Wh1XgMk3T-Vg" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                        <Children>
-                          <Parameter id="UkyUmXnSE0i2nugdQJGTxA" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                          <Parameter id="k0_5Bf45TkqojesZprb-xw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="ZN6lG_Ebx06vADepLGc0tA" visible="0" canBeVaried="0" />
-                          <Observer id="ZgSSw3nnl0SfP38ELcZVhA" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
-                        </Children>
-                      </MoleculeAmount>
-                    </Children>
-                  </Container>
-                  <Container id="O-o-8OxoS0qRhVdCLAcbCA" name="Mucosa" description="Mucosa" mode="Logical" containerType="Compartment">
-                    <Children>
-                      <Container id="m4j5fI7PKE-bxd1FVoOodQ" name="Duodenum" description="Duodenum" icon="Duodenum" mode="Logical" containerType="Compartment">
-                        <Children>
-                          <Parameter id="D8KQXmJRcU6mz1dXNzZaQg" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="uSjt8LuoBUu75Z4-7ZUOCw" visible="0" canBeVaried="1" displayUnit="kg" />
-                          <Parameter id="nAjAe0_UL0CFbinyd65AQw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="LEwTV4qfP0OlLU7itHSbkA" visible="1" canBeVaried="1" displayUnit="l" />
-                          <Parameter id="U1i8vDNMyEynpYa4ZbUrjw" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="Gjt25Z3wS0ulOtVbHUeTPg" visible="1" canBeVaried="0" displayUnit="l" />
-                          <Parameter id="pRToj5-K00qu7_bKGwohsA" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="et1rku1VQkqZCxraRd0LsA" visible="1" canBeVaried="1" displayUnit="l/min" />
-                          <Parameter id="hunF4gHmI0athAprfNZo9A" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="NxoV47Ql00aifPKqk7nOJw" visible="1" canBeVaried="1" displayUnit="l/min" />
-                          <Parameter id="7BZIc8W7LEWpc4f6lqGybA" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="cDO00dCgEUa1Rf_VnhA32g" visible="1" canBeVaried="1" displayUnit="l/min" />
-                          <Parameter id="l9Ur1t2v9ku9FAONaltcGA" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="LSHvGCmOBEascdPo-Ab-KQ" visible="1" canBeVaried="1" />
-                          <Parameter id="37qQbg8kJEWr_P79ZSnZ_A" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                          <Parameter id="8FLkOmcq8UClOkgBVyhdvA" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                          <Parameter id="1WdLyPzu3ECuPgVfU79gCw" name="Fraction of regional blood flow rate" description="Regional blood flow fraction supplying the mucosal tissue of the segment" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.093" />
-                          <Parameter id="hx4477ldrEuEIxRg1ie6Ng" name="Fraction mucosa" description="Mucosal fraction of regional intestinal tissue mass" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.26" />
-                          <Parameter id="XOD_X9KaiE-vddY_M8U3tw" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" visible="1" canBeVaried="1" value="1.53888888888889E-10" displayUnit="ml/min/N" />
-                          <Parameter id="rXSm6o3-z0-ZZiiBcpQo9g" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="2.5E-07" displayUnit="µm" />
-                          <Parameter id="1O0mOwHycE68LyIEb_BnHw" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.05" />
-                          <Parameter id="xeI97SBKbEW9QStixbfPxA" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="4.5E-08" displayUnit="µm" />
-                          <Parameter id="rjBebaWyrkqink6aeZQ3mg" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.06" />
-                          <Parameter id="juoMvfbTk0ej0sVVF9OlKA" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0487" />
-                          <Parameter id="ZVf_kfeOMEyLDMFKwHOkRQ" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.13" />
-                          <Parameter id="7PqTebMr5EmiXIrDCu9fnA" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0163" />
-                          <Parameter id="FWbU_ulnZ0CpmK0wZPk9LQ" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.08" />
-                          <Parameter id="YgUuJlVjtEqj6xYcszo6-Q" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.158" />
-                          <Parameter id="UGiiQo6sSkeO-w2sMhwD9A" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.141" />
-                          <Parameter id="A-aAvRSQLEiWXNFPCvzj5Q" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-                          <Parameter id="Sykm4E6CJEauQXxVgQrJ9w" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.718" />
-                          <Parameter id="Azo_KpS7lU-hrRq_pjpA6w" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.8" />
-                          <Parameter id="f8U8SGuYW0afVR7aUafmFg" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.42" />
-                          <Parameter id="O3vqu2ACIkKS_oDDuLI9TQ" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0483" />
-                          <Parameter id="ciOPGvs7PE6U3F4PFXcGrg" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0375" />
-                          <Parameter id="W9wpZ1UWjEWIRZ8bXw1mQA" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0182" />
-                          <Parameter id="dcuVkGCZVkeJc9ffWC5-Fg" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0124" />
-                          <Parameter id="VRFpGNpLTE230F9ZM48eqQ" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.15" />
-                          <Parameter id="PmfFKqycCk6PknG9sCiCpA" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.282" />
-                          <Parameter id="eqytgZ8gDUWVGzPrOYjlxg" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.456" />
-                          <Parameter id="MXGGrIBDY0iQmIX0lA6Lrg" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.78" />
-                          <Parameter id="XpRQ3W26iEqvk94kPDNZqw" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="2.41" />
-                          <Parameter id="yE2XuyllIUGuAIb3-NRaJg" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0035" />
-                          <Container id="5qa_dNfzPEqENSftAboAkA" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                            <Tags>
-                              <Tag value="Duodenum" />
-                              <Tag value="Mucosa" />
-                              <Tag value="SmallIntestineSegment" />
-                            </Tags>
-                            <Children>
-                              <Parameter id="XdG4LdZR2Eez6UX2-CUStQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                              <Parameter id="UN53LMBerEWejPLn3wJCJQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="AWSLB9BqIUm588s01h4uMw" visible="1" canBeVaried="1" displayUnit="l" />
-                              <MoleculeAmount id="9U0qncgJp0GzhMN51sFuvg" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                                <Children>
-                                  <Parameter id="zk-Anpflt0OM4wrSb0x37g" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                                  <Parameter id="tOqAgFa_N0eBvBKQSSvS_w" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="jq9rwlKf70-gdm8c2FOCHQ" visible="0" canBeVaried="0" />
-                                  <Observer id="xhAAuh0eKEmfiNlr8xakzg" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
-                                </Children>
-                              </MoleculeAmount>
-                            </Children>
-                          </Container>
-                          <Container id="TdV1_un1aESakxFEr6GkQw" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                            <Tags>
-                              <Tag value="Duodenum" />
-                              <Tag value="Mucosa" />
-                              <Tag value="SmallIntestineSegment" />
-                            </Tags>
-                            <Children>
-                              <Parameter id="61b9F_7o70ChZ9WnM1xXZQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                              <Parameter id="DFb9vsRH1kChNcVr3hHd7A" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="bFSKBq9P6ESwCQ7kJZpF0A" visible="1" canBeVaried="1" displayUnit="l" />
-                              <MoleculeAmount id="F5meuBt0ck6H-U7fLJ-DUg" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                                <Children>
-                                  <Parameter id="VFAbr_GcRkyA9ospuzOV_A" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                                  <Parameter id="OZAbtKMrcE6W4dJQdw2v9Q" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="SP-USg-WBUmt6v_dRgolcg" visible="0" canBeVaried="0" />
-                                  <Observer id="RNwcY6-NHUC6LiSKOXzkkQ" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
-                                </Children>
-                              </MoleculeAmount>
-                            </Children>
-                          </Container>
-                          <Container id="qdfrt7fje02lpLnQb4CGDw" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                            <Tags>
-                              <Tag value="Duodenum" />
-                              <Tag value="Mucosa" />
-                              <Tag value="SmallIntestineSegment" />
-                            </Tags>
-                            <Children>
-                              <Parameter id="a0F1kyVbWkWbeZc6QNphdQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                              <Parameter id="xon0ziiVA0utJYWwvIHEMA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="5D8ZOzXK7EGOwj3jJsZ67w" visible="1" canBeVaried="1" displayUnit="l" />
-                              <Parameter id="XHlUadGVJUClSCL5BUNdRA" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="mmPlMPjMnECVqmG5mkXJMw" visible="1" canBeVaried="1" />
-                              <MoleculeAmount id="fg-dyqp9w0KRdVpmwPAxnw" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                                <Children>
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-                                  <Parameter id="NNXpvcvJtkqu9ODzZW0pzQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="GDiNoHTX_kq4gWMn4xyfXQ" visible="0" canBeVaried="0" />
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-                          <Container id="34MfH5c9wEKhN-FvYBmvow" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                            <Tags>
-                              <Tag value="Duodenum" />
-                              <Tag value="IntestinalSecretionSource" />
-                              <Tag value="Mucosa" />
-                              <Tag value="SmallIntestineSegment" />
-                            </Tags>
-                            <Children>
-                              <Parameter id="hbVnDgZepkKTCIpmHCV_NQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="dE28EI6hVk23fUjk1luoMw" visible="0" canBeVaried="0" displayUnit="l" />
-                              <Parameter id="o1aUnFQazUyg1R1Gq4TXLA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="m5gWJCaKR0mYkdrFJN9OsQ" visible="1" canBeVaried="1" displayUnit="l" />
-                              <Parameter id="7jYS_krRZEeUp2SIGNUfog" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.3" />
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-                                  <Parameter id="I3attplpzki7htmJ7DcfEg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="ChmPga5ht0mpWfM3jBqM6Q" visible="0" canBeVaried="0" />
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-                        <Children>
-                          <Parameter id="o7OFMsDzcUqA3lsyuyDHbA" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="uSjt8LuoBUu75Z4-7ZUOCw" visible="0" canBeVaried="1" displayUnit="kg" />
-                          <Parameter id="MFiW7RmTsUa1fa9U3BhrpQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="kgDIgONbXkqnjbETwU5R_A" visible="1" canBeVaried="1" displayUnit="l" />
-                          <Parameter id="hmwMonK5JEarrbvj8Kr2Qg" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="et1rku1VQkqZCxraRd0LsA" visible="1" canBeVaried="1" displayUnit="l/min" />
-                          <Parameter id="VydrkZ3PqEi2EMb4VD4hcw" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="YR0X7Z-NMEyBlSl8AIu6OA" visible="1" canBeVaried="0" displayUnit="l" />
-                          <Parameter id="s9GHNl3Jf0iof2pinoQJBQ" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="NxoV47Ql00aifPKqk7nOJw" visible="1" canBeVaried="1" displayUnit="l/min" />
-                          <Parameter id="BcFxDYH7z0C_sWSfCsgvCg" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="cDO00dCgEUa1Rf_VnhA32g" visible="1" canBeVaried="1" displayUnit="l/min" />
-                          <Parameter id="GIvP_IuR4E2b_ZcJEcAVJA" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="LSHvGCmOBEascdPo-Ab-KQ" visible="1" canBeVaried="1" />
-                          <Parameter id="PSRVYuWbZUWEWYRst5gFvA" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                          <Parameter id="DvSucqaFcEO_qdyeMBj1Fg" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                          <Parameter id="fgKXvGVLuEGLXjSKj4qAfQ" name="Fraction mucosa" description="Mucosal fraction of regional intestinal tissue mass" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.26" />
-                          <Parameter id="44nzZX9x3E-cygDfZKdiGA" name="Fraction of regional blood flow rate" description="Regional blood flow fraction supplying the mucosal tissue of the segment" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.219" />
-                          <Parameter id="Stdh4QnSLkGt_ARfZ5qnkg" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" visible="1" canBeVaried="1" value="1.53888888888889E-10" displayUnit="ml/min/N" />
-                          <Parameter id="VlUcyQZKrEeYXrYIp7CNrg" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.05" />
-                          <Parameter id="WTmfJ50uyEm0tn2Vgq05uA" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="4.5E-08" displayUnit="µm" />
-                          <Parameter id="znI09G-AAkyAD81UW5zr2g" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="2.5E-07" displayUnit="µm" />
-                          <Parameter id="qNCKBLNBhEqNiBr0sZFqGA" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.06" />
-                          <Parameter id="Er1kNNcfPkuBwPAlQs002Q" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0487" />
-                          <Parameter id="jBWtfuDqWkK1cx25BWz_Rg" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.13" />
-                          <Parameter id="oFR4nOXk6k-XooGxVBKcmA" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.08" />
-                          <Parameter id="1KN1Zs87e0GGtVUerfqCAA" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0163" />
-                          <Parameter id="FWHyocoYIEm0kbvcsZamQA" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.718" />
-                          <Parameter id="-sg7u430SE6nGaHxDEFtJg" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.141" />
-                          <Parameter id="Ny-h3YfpEkCuv4P00ABlsA" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-                          <Parameter id="at3aiRA7M0udzecPvTZxzw" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.8" />
-                          <Parameter id="jFcA-n-x-km_Xcv5MB8h1g" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.158" />
-                          <Parameter id="jvEs1suJdkGUO3Mb49Ndmg" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.35" />
-                          <Parameter id="PFUU2noWo02P7Lb1uoVB-Q" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0375" />
-                          <Parameter id="qYq1MFCHXESiJNj72Br0hA" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0483" />
-                          <Parameter id="JPrYLoTD1kexp8J35vN_ng" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0182" />
-                          <Parameter id="RJ2te8tXbkWKQAs3oEk_2A" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0124" />
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-                          <Parameter id="crUXSI5lmECgXCHg6uUV0A" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.282" />
-                          <Parameter id="n1YBAjNlhEe3TI33rVemkA" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.78" />
-                          <Parameter id="yHADKhHwAUCHrBYwQT9o-A" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.456" />
-                          <Parameter id="rCMV6hOPkE6zDcYjbzaNBA" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="2.41" />
-                          <Parameter id="zmxkf1WD3UWYN58ERmu8MA" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0035" />
-                          <Container id="Mqff24qDg0q3J5knCoXTZw" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                            <Tags>
-                              <Tag value="Mucosa" />
-                              <Tag value="SmallIntestineSegment" />
-                              <Tag value="UpperJejunum" />
-                            </Tags>
-                            <Children>
-                              <Parameter id="9pZv2fydg0uyWU8W7m5fAQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                              <Parameter id="7lSPYpZvaUSQe-Je2rJysw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="AWSLB9BqIUm588s01h4uMw" visible="1" canBeVaried="1" displayUnit="l" />
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-                                  <Parameter id="HEQf0j3Il060-DSH3yWK1g" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="QffwbOSrkkiW4JNbgcATVg" visible="0" canBeVaried="0" />
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-                          <Container id="BiBid5i4Sk2EK94scFpeHw" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                            <Tags>
-                              <Tag value="Mucosa" />
-                              <Tag value="SmallIntestineSegment" />
-                              <Tag value="UpperJejunum" />
-                            </Tags>
-                            <Children>
-                              <Parameter id="MSdOwPme6km6t-3LjklkEg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                              <Parameter id="aY5o5qed_kmAOeLAUlsQzw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="bFSKBq9P6ESwCQ7kJZpF0A" visible="1" canBeVaried="1" displayUnit="l" />
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-                                  <Parameter id="T-XvZLzu2U-d-m5p6UdF7A" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="KRWWfL3ct0q8SR3V-8fG7g" visible="0" canBeVaried="0" />
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-                            <Tags>
-                              <Tag value="Mucosa" />
-                              <Tag value="SmallIntestineSegment" />
-                              <Tag value="UpperJejunum" />
-                            </Tags>
-                            <Children>
-                              <Parameter id="iLaRY1ogO0eKiDJX84Tmrw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                              <Parameter id="-ybGu-spkUy6PNHi7dV5AA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="5D8ZOzXK7EGOwj3jJsZ67w" visible="1" canBeVaried="1" displayUnit="l" />
-                              <Parameter id="QeRPWWAshUqjZHw4yQDNOA" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="mmPlMPjMnECVqmG5mkXJMw" visible="1" canBeVaried="1" />
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-                                  <Parameter id="Iim9CTisdUyf_AcwYaGB8A" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CFYGaPnhW0mmkmVj-xHe8w" visible="0" canBeVaried="0" />
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-                            <Tags>
-                              <Tag value="IntestinalSecretionSource" />
-                              <Tag value="Mucosa" />
-                              <Tag value="SmallIntestineSegment" />
-                              <Tag value="UpperJejunum" />
-                            </Tags>
-                            <Children>
-                              <Parameter id="glvmjwTNvUCVxMSOMbem0Q" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="dE28EI6hVk23fUjk1luoMw" visible="0" canBeVaried="0" displayUnit="l" />
-                              <Parameter id="fIzKnk6CZUq4lx-ZJo_tjQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="m5gWJCaKR0mYkdrFJN9OsQ" visible="1" canBeVaried="1" displayUnit="l" />
-                              <Parameter id="O6ZyXUkTh0KoqrGHAYtyuw" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.3" />
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-                                  <Parameter id="-nCsN_SkzEma-XbogKiQIw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="zIZuOF2sfk6V6fn8-pAeQQ" visible="0" canBeVaried="0" />
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-                        <Children>
-                          <Parameter id="FcSCehu420Gq7jYKQfOjFQ" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="uSjt8LuoBUu75Z4-7ZUOCw" visible="0" canBeVaried="1" displayUnit="kg" />
-                          <Parameter id="4Zl-usFhTkiwcDJfZR8CgA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="bqtF4r268EyXGPbRGI3j_Q" visible="1" canBeVaried="1" displayUnit="l" />
-                          <Parameter id="-aOfmleAHk-1PBVPq9IbzA" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="NxoV47Ql00aifPKqk7nOJw" visible="1" canBeVaried="1" displayUnit="l/min" />
-                          <Parameter id="MjMkF1cDLU6ajDcmS6QRcg" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="et1rku1VQkqZCxraRd0LsA" visible="1" canBeVaried="1" displayUnit="l/min" />
-                          <Parameter id="EZ_SSYj70UeU3GWoz5IFUQ" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="iJA8m8URWU2VwP_yDL9F0g" visible="1" canBeVaried="0" displayUnit="l" />
-                          <Parameter id="LyNzZOFHLUGcENaiOvci_w" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="cDO00dCgEUa1Rf_VnhA32g" visible="1" canBeVaried="1" displayUnit="l/min" />
-                          <Parameter id="SuRgVQUiXEimPeCoeqqceA" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="LSHvGCmOBEascdPo-Ab-KQ" visible="1" canBeVaried="1" />
-                          <Parameter id="C0uc0wakmkGm0vpW8Bqkvg" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                          <Parameter id="K01QDC-1I02M5cURc38eqw" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                          <Parameter id="WhaWe09xhEKOuJwG1ySfgg" name="Fraction of regional blood flow rate" description="Regional blood flow fraction supplying the mucosal tissue of the segment" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.219" />
-                          <Parameter id="KTT8HDWzSU-kZrJRNploVg" name="Fraction mucosa" description="Mucosal fraction of regional intestinal tissue mass" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.26" />
-                          <Parameter id="S_g_1ts3QEOKSmHxUhQonA" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="4.5E-08" displayUnit="µm" />
-                          <Parameter id="7jt4l4R-IkOilzx6dn-KgA" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.05" />
-                          <Parameter id="kY1TIpU40ECUiHMk68MKgg" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" visible="1" canBeVaried="1" value="1.53888888888889E-10" displayUnit="ml/min/N" />
-                          <Parameter id="Fkg7xkMuJUqjtQiiXVzbcQ" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="2.5E-07" displayUnit="µm" />
-                          <Parameter id="FhxaXwiLxUelk9Ydl9vQAA" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0487" />
-                          <Parameter id="FGVorR2B_U2ttGh3WNaOLQ" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.06" />
-                          <Parameter id="ypYgIS8k0UmTOQjAbt9Ang" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.13" />
-                          <Parameter id="uzC6Gbtt60aicCgT-sYEWQ" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0163" />
-                          <Parameter id="h8VhYsI6m06AnN7UaIHHSA" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.08" />
-                          <Parameter id="-fzUuj1wPEa4jaFHr3VO_A" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.158" />
-                          <Parameter id="KfUkDJsiL06tLsz0x3Xrrw" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.141" />
-                          <Parameter id="gIUX2Mf4Bkic-A_T0-qMaw" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-                          <Parameter id="i2QyvTBsyU-D-Xjjap2OFQ" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.8" />
-                          <Parameter id="jXw7bc9ky0SYBAXVjKaEIg" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.718" />
-                          <Parameter id="Qjl8k5lYc0Os3RdB-V4PTA" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.32" />
-                          <Parameter id="_A8Da_XDFk6OiYQiryeBHA" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0483" />
-                          <Parameter id="73W2It3JVEWfLHZXLFMMHA" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0375" />
-                          <Parameter id="8u4-mOEDwkGYb0femuQGHw" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0182" />
-                          <Parameter id="8F3J87kdQ0CGQp9NAI5qwg" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0124" />
-                          <Parameter id="phcPkvF3XkyKlKyM_U6mQw" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.282" />
-                          <Parameter id="ILvUiGlLoUSwaBiZqKzW_A" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.15" />
-                          <Parameter id="MS1W88Nx6EKp8S1yfeec_Q" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.456" />
-                          <Parameter id="eTNSoflQR0mXIG7SIUJqrw" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.78" />
-                          <Parameter id="4x4P-JJuQk-_1MQYM5TBug" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0035" />
-                          <Parameter id="VSX5SCOSXEyPJAb6Pn8tSQ" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="2.41" />
-                          <Container id="qnwzbs7P1EuiOU6I1AbUmw" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                            <Tags>
-                              <Tag value="LowerJejunum" />
-                              <Tag value="Mucosa" />
-                              <Tag value="SmallIntestineSegment" />
-                            </Tags>
-                            <Children>
-                              <Parameter id="bwg1-jjTUEmRIIHpuy2wZA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                              <Parameter id="kA9hRQfvwEeGehL_vWyKUA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="AWSLB9BqIUm588s01h4uMw" visible="1" canBeVaried="1" displayUnit="l" />
-                              <MoleculeAmount id="YgLswliwdkSHukAAVZwL5w" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                                <Children>
-                                  <Parameter id="oksD5869zkiTJXLh4toR5Q" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                                  <Parameter id="fxYwuGFa70iZWyscYL2xUA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Llk4QPlyyUKwCA3NV-Fqig" visible="0" canBeVaried="0" />
-                                  <Observer id="eMdZWOctjEOtGBj4WYQXAQ" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
-                                </Children>
-                              </MoleculeAmount>
-                            </Children>
-                          </Container>
-                          <Container id="kDMQj4cgPkq4YoBI6vj_HA" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                            <Tags>
-                              <Tag value="LowerJejunum" />
-                              <Tag value="Mucosa" />
-                              <Tag value="SmallIntestineSegment" />
-                            </Tags>
-                            <Children>
-                              <Parameter id="RaEGjp8bUEiuQWqE3ChP_w" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                              <Parameter id="qCqBef0L9Ui7tsixNU_zLg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="bFSKBq9P6ESwCQ7kJZpF0A" visible="1" canBeVaried="1" displayUnit="l" />
-                              <MoleculeAmount id="6Aqs6_wfI0OKiplexvNuNQ" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                                <Children>
-                                  <Parameter id="SGIGHLhcOkyDfMgdhPidHQ" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                                  <Parameter id="4tB8D5Jrr0qDZE6rplODRA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="5QavN5Cuck-hEPiYzmGVag" visible="0" canBeVaried="0" />
-                                  <Observer id="zyYgmYRgrU-3ZMK7zqD-wg" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
-                                </Children>
-                              </MoleculeAmount>
-                            </Children>
-                          </Container>
-                          <Container id="QujFSUBKfUuVAqdGlF3CiA" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                            <Tags>
-                              <Tag value="LowerJejunum" />
-                              <Tag value="Mucosa" />
-                              <Tag value="SmallIntestineSegment" />
-                            </Tags>
-                            <Children>
-                              <Parameter id="nTVRotxiAE2862TTR0dhhw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                              <Parameter id="rbBm2GpWCUKeu-NXNhaYTQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="5D8ZOzXK7EGOwj3jJsZ67w" visible="1" canBeVaried="1" displayUnit="l" />
-                              <Parameter id="iqz0l-VzL0qcrE2sXvfNtQ" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="mmPlMPjMnECVqmG5mkXJMw" visible="1" canBeVaried="1" />
-                              <MoleculeAmount id="84aiMNio202GvttS4U_60A" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                                <Children>
-                                  <Parameter id="O1dUJjtW_k6tiIPZ3HBEFg" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                                  <Parameter id="Gi6EB0asS060NQWAA8Vx6w" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="p7zZOcLuiE6avIw0GgF-Kg" visible="0" canBeVaried="0" />
-                                  <Observer id="fcKRCb7VvUGxhxXU4FQ0SQ" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
-                                </Children>
-                              </MoleculeAmount>
-                            </Children>
-                          </Container>
-                          <Container id="ZS1XYMqua0eBDvqguAeY6g" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                            <Tags>
-                              <Tag value="IntestinalSecretionSource" />
-                              <Tag value="LowerJejunum" />
-                              <Tag value="Mucosa" />
-                              <Tag value="SmallIntestineSegment" />
-                            </Tags>
-                            <Children>
-                              <Parameter id="JZQno6WPD0eFeJoyL7b9yQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="dE28EI6hVk23fUjk1luoMw" visible="0" canBeVaried="0" displayUnit="l" />
-                              <Parameter id="INGtHoBCYEuX-clsHxPbaw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="m5gWJCaKR0mYkdrFJN9OsQ" visible="1" canBeVaried="1" displayUnit="l" />
-                              <Parameter id="z78u_Iw6QU6UqznIfb8XaQ" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.3" />
-                              <MoleculeAmount id="K8vctNgQvkyF2UEwPTSuVQ" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                                <Children>
-                                  <Parameter id="WUt_eRU_LUOkJSOVNlxdDg" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                                  <Parameter id="sMuKWCO6kU2ks8f8t4-EvA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="FlefxO_e3E2iFGIMQcLe0A" visible="0" canBeVaried="0" />
-                                  <Observer id="LQ52rLkj2kqlX_lCNj8O0w" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
-                                </Children>
-                              </MoleculeAmount>
-                            </Children>
-                          </Container>
-                        </Children>
-                      </Container>
-                      <Container id="KbC-uzdqU0a1SZxdZSTRvA" name="UpperIleum" description="Upper Ileum" icon="UpperIleum" mode="Logical" containerType="Compartment">
-                        <Children>
-                          <Parameter id="nkAgVyMIsUCSjyKaNY0YwA" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="uSjt8LuoBUu75Z4-7ZUOCw" visible="0" canBeVaried="1" displayUnit="kg" />
-                          <Parameter id="M18mtnwvIUiQdTYEFB0_pA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="yWKGF2k4XUi8tUSvNhq92Q" visible="1" canBeVaried="1" displayUnit="l" />
-                          <Parameter id="baUnlLkY1k-dGonvxnQNjQ" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="NxoV47Ql00aifPKqk7nOJw" visible="1" canBeVaried="1" displayUnit="l/min" />
-                          <Parameter id="v3wkF0IOHU24n9qJqllYNA" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="et1rku1VQkqZCxraRd0LsA" visible="1" canBeVaried="1" displayUnit="l/min" />
-                          <Parameter id="rTDKYhJQXU2uRpdG62dddA" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="4_Uh7N-65UW8fTmjbmsOPA" visible="1" canBeVaried="0" displayUnit="l" />
-                          <Parameter id="rfn7j5arUEaU1Waomvp5gg" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="cDO00dCgEUa1Rf_VnhA32g" visible="1" canBeVaried="1" displayUnit="l/min" />
-                          <Parameter id="vqccau4QnkKd6usOVX7-aw" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="LSHvGCmOBEascdPo-Ab-KQ" visible="1" canBeVaried="1" />
-                          <Parameter id="2D7EPT3cj0WAf7W697MjEQ" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                          <Parameter id="5qqYeaK6B02Z7HDpvKSWYg" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                          <Parameter id="z7l8OUvVRUisqzHG7lX0eQ" name="Fraction mucosa" description="Mucosal fraction of regional intestinal tissue mass" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.13" />
-                          <Parameter id="M-z0Yo5150KsuwMEc6ZlZA" name="Fraction of regional blood flow rate" description="Regional blood flow fraction supplying the mucosal tissue of the segment" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.2345" />
-                          <Parameter id="FfVC9m5rqky28hHQ_S9-ww" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="2.5E-07" displayUnit="µm" />
-                          <Parameter id="9UHLkmmOm0S84ObA7qt8SQ" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" visible="1" canBeVaried="1" value="1.53888888888889E-10" displayUnit="ml/min/N" />
-                          <Parameter id="2p-OMgpUsk2ZxR0RJxhSFw" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.05" />
-                          <Parameter id="BVLP5Z-tC0qGcVzIZUMjTw" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="4.5E-08" displayUnit="µm" />
-                          <Parameter id="PWrA6RLHWUyc07Tf-dBsfw" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.06" />
-                          <Parameter id="7NQQJDH8BEaUWFf7o56gHg" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0487" />
-                          <Parameter id="595Hm29RDECAiC53Spry4A" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.13" />
-                          <Parameter id="3cJWUf7jPUeRERfZtiKNRQ" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.08" />
-                          <Parameter id="2ZVp7pF0rkO_MbJunYtGpA" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0163" />
-                          <Parameter id="sxJFERj4W0iYleBHvjVrCg" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.8" />
-                          <Parameter id="Sq_WT3lL9kumptVFjk0CeA" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.158" />
-                          <Parameter id="OrJf314V6EyNp4441UdoQw" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.141" />
-                          <Parameter id="FSC5FZqGpUqxCVvU1SQaaw" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-                          <Parameter id="p0p03vuyoEeZcowgRm6mGQ" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.718" />
-                          <Parameter id="Yl9DnuplEE2O8L4aZ4VRKA" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.31" />
-                          <Parameter id="g0hU5jg6mkW8NKHg20Ddsg" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0483" />
-                          <Parameter id="V2Zkmk_YRESGV_bYO_Jeww" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0375" />
-                          <Parameter id="fP-1uJ-CrUKdy0TVAnIYtg" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0124" />
-                          <Parameter id="jyp6jNPdqEagPQokk2lTMA" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0182" />
-                          <Parameter id="eyW6dw6J0k6KLMtsvN6-Pw" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.282" />
-                          <Parameter id="Z9ZE8G1sZ0KS-OZCJ5HGSw" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.15" />
-                          <Parameter id="wbMt8QzlTkiNnUMgD1DZjw" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.78" />
-                          <Parameter id="y018doGg40iq2VUqCWLmyA" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.456" />
-                          <Parameter id="hLUKdJdoNk-xyKHognbgRw" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0035" />
-                          <Parameter id="MDFv0D2Ga0uoTV67ZtN45Q" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="2.41" />
-                          <Container id="wiKdxf5lkUaXODbbzJ_MgA" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                            <Tags>
-                              <Tag value="Mucosa" />
-                              <Tag value="SmallIntestineSegment" />
-                              <Tag value="UpperIleum" />
-                            </Tags>
-                            <Children>
-                              <Parameter id="7mCV0eypi0S5ql3lQLmcaA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                              <Parameter id="OwynRWIMIkS2jZMUMX65ow" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="AWSLB9BqIUm588s01h4uMw" visible="1" canBeVaried="1" displayUnit="l" />
-                              <MoleculeAmount id="OH4tJOZD_USLmfI7ahxt3w" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                                <Children>
-                                  <Parameter id="ek4WCEc6v0yuzxuhwnBBLQ" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                                  <Parameter id="2k4e7jPJZkubhZrj68088w" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="WlOg-KUZREW2kU3ietRnlQ" visible="0" canBeVaried="0" />
-                                  <Observer id="bTrYKIyHjUeLiR6tLw_X0g" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
-                                </Children>
-                              </MoleculeAmount>
-                            </Children>
-                          </Container>
-                          <Container id="PSVoSQGqZEqHtyvSo86Uug" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                            <Tags>
-                              <Tag value="Mucosa" />
-                              <Tag value="SmallIntestineSegment" />
-                              <Tag value="UpperIleum" />
-                            </Tags>
-                            <Children>
-                              <Parameter id="HI6IFHB8E0Wdxvnt_d20IQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                              <Parameter id="8Xns6YLi20u4iHlMN80EGQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="bFSKBq9P6ESwCQ7kJZpF0A" visible="1" canBeVaried="1" displayUnit="l" />
-                              <MoleculeAmount id="AmS23HbI_0aVgZpvEhgrww" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                                <Children>
-                                  <Parameter id="I3FvuKh400KDyTVf9_yyTg" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                                  <Parameter id="TV8S5oW060al1vPe-y8w7w" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="VOEd7LQgokykILce_YRefQ" visible="0" canBeVaried="0" />
-                                  <Observer id="Z0ctV3kILkykZXdqpFi29g" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
-                                </Children>
-                              </MoleculeAmount>
-                            </Children>
-                          </Container>
-                          <Container id="mL_v9Y4FbUCAI1t4VRNB6g" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                            <Tags>
-                              <Tag value="Mucosa" />
-                              <Tag value="SmallIntestineSegment" />
-                              <Tag value="UpperIleum" />
-                            </Tags>
-                            <Children>
-                              <Parameter id="155gw5ARVEC9_pEvZvMSbw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                              <Parameter id="PytdbaiZU0-48jusL-pLxQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="5D8ZOzXK7EGOwj3jJsZ67w" visible="1" canBeVaried="1" displayUnit="l" />
-                              <Parameter id="9MktmCGmq0ezHfCcwuLqig" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="mmPlMPjMnECVqmG5mkXJMw" visible="1" canBeVaried="1" />
-                              <MoleculeAmount id="hrj09OGQBE2Gcy30ntzRWA" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                                <Children>
-                                  <Parameter id="_E2x8ZB59E-XBkTjZF975A" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                                  <Parameter id="eVZhYTgNu06kB5YhmL-IJg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Xzi_1qWplkq8DZexTbsA2w" visible="0" canBeVaried="0" />
-                                  <Observer id="JcrbSx4pr0eWm9XILuKqHw" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
-                                </Children>
-                              </MoleculeAmount>
-                            </Children>
-                          </Container>
-                          <Container id="Mn_3bNMJfUilEEDCF8BgJg" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                            <Tags>
-                              <Tag value="IntestinalSecretionSource" />
-                              <Tag value="Mucosa" />
-                              <Tag value="SmallIntestineSegment" />
-                              <Tag value="UpperIleum" />
-                            </Tags>
-                            <Children>
-                              <Parameter id="Xs2TjAIaC0ylwLoMFWuCJA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="dE28EI6hVk23fUjk1luoMw" visible="0" canBeVaried="0" displayUnit="l" />
-                              <Parameter id="SyRWsTuZRUGftAIdBcx1Ng" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="m5gWJCaKR0mYkdrFJN9OsQ" visible="1" canBeVaried="1" displayUnit="l" />
-                              <Parameter id="f6LxQxrXZU6F5jS0GL8SlA" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.3" />
-                              <MoleculeAmount id="27w6YBfNQkyh-7D9Mivddg" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                                <Children>
-                                  <Parameter id="8tZhCW4t4EKOxWnokgEaJQ" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                                  <Parameter id="l5b7hynXBkGbcZEnEaYPuA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="5oh8RmywUUKfE_PYhuYHaQ" visible="0" canBeVaried="0" />
-                                  <Observer id="GrQM3HWG80qoqwRhpF3c1Q" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
-                                </Children>
-                              </MoleculeAmount>
-                            </Children>
-                          </Container>
-                        </Children>
-                      </Container>
-                      <Container id="A5EY2dtuQ0S8dsnX4o_ZBw" name="LowerIleum" description="Lower Ileum" icon="LowerIleum" mode="Logical" containerType="Compartment">
-                        <Children>
-                          <Parameter id="pRaE-fqj7EaWUq1bUijMUg" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="uSjt8LuoBUu75Z4-7ZUOCw" visible="0" canBeVaried="1" displayUnit="kg" />
-                          <Parameter id="uxsyk0q-uUSIZgiV95fDuw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="48pb79Tg_U2mIwfCNKEWrQ" visible="1" canBeVaried="1" displayUnit="l" />
-                          <Parameter id="DgN36nSdRECkDw2GaI_Yvg" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="PpDtkQj1SkWhFoXwJa9W1w" visible="1" canBeVaried="0" displayUnit="l" />
-                          <Parameter id="slScpueehU-49-Faxub2kA" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="et1rku1VQkqZCxraRd0LsA" visible="1" canBeVaried="1" displayUnit="l/min" />
-                          <Parameter id="s_OW-E3HTEWBJXNASXTKLg" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="NxoV47Ql00aifPKqk7nOJw" visible="1" canBeVaried="1" displayUnit="l/min" />
-                          <Parameter id="UQ8B5duYX0WGAKNQ0OAArA" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="cDO00dCgEUa1Rf_VnhA32g" visible="1" canBeVaried="1" displayUnit="l/min" />
-                          <Parameter id="Uy5YNxgepEuh3bEH96ipFw" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="LSHvGCmOBEascdPo-Ab-KQ" visible="1" canBeVaried="1" />
-                          <Parameter id="qO5YW2KdZEeTvma7TDw7ag" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                          <Parameter id="Mh2iKPmUxk2uph-M_capjw" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                          <Parameter id="v_RGIJnNj0GCRAxE9fqXcQ" name="Fraction mucosa" description="Mucosal fraction of regional intestinal tissue mass" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.13" />
-                          <Parameter id="cvYJX-HYkESo-8Al_9rQ0Q" name="Fraction of regional blood flow rate" description="Regional blood flow fraction supplying the mucosal tissue of the segment" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.2345" />
-                          <Parameter id="hxZOBOm3yUKrrjQwjWWP3w" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.05" />
-                          <Parameter id="lp6OSm-LXUi_Mgc_uQ65lg" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="4.5E-08" displayUnit="µm" />
-                          <Parameter id="nEDogpTmhkiQYkoADJWH_w" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" visible="1" canBeVaried="1" value="1.53888888888889E-10" displayUnit="ml/min/N" />
-                          <Parameter id="2sbmJz3Fr0mJqX36vn2qAw" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="2.5E-07" displayUnit="µm" />
-                          <Parameter id="Zdhfk1g88UCp1SktFfl24g" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0487" />
-                          <Parameter id="cApgcyLWGk-8JtQ8jTlCWg" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.06" />
-                          <Parameter id="j61L6PTak0OzC3Ey7WHN4Q" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.13" />
-                          <Parameter id="sTVH2yOEakeJjzxJbJswrA" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0163" />
-                          <Parameter id="1m682-B9ZEWrVvHsJIBbsw" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.08" />
-                          <Parameter id="RLFTy-BP6EOssm4HF8x8yw" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.158" />
-                          <Parameter id="so9sk59y9kmTJj3QyYz7JQ" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.141" />
-                          <Parameter id="Edngv139pk2-OvkbmgsZYA" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-                          <Parameter id="rMi8u_DsF0a5KS5H9GvR_Q" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.718" />
-                          <Parameter id="aAShIyFfkUimOO86oFBbUA" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.8" />
-                          <Parameter id="zzzz6hIAd023plfAQmMbRA" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.32" />
-                          <Parameter id="icpLLQjiREyftl8Vsp_Rww" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0483" />
-                          <Parameter id="IPmbpkclwUejj4HKVa7wvA" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0375" />
-                          <Parameter id="bjQMuK4H40-SXVj3DpKjYQ" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0124" />
-                          <Parameter id="KWzujO57mkGK9tez-MepsA" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0182" />
-                          <Parameter id="fh9cBtVAP0-U0RXuTbnmsA" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.15" />
-                          <Parameter id="2jEjimbut0OUxDbEzgrW5g" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.282" />
-                          <Parameter id="jlVMMWYWzEO-Z-bJmPvoEg" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.456" />
-                          <Parameter id="-MGJ6tqntUSMoDIU3ihNgA" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.78" />
-                          <Parameter id="fx5DFXNvQEOIDxAeVByIxw" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0035" />
-                          <Parameter id="K97yL1hQZ0iujRnrMoSsaA" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="2.41" />
-                          <Container id="rrdHQQGA002quyiJj14SNw" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                            <Tags>
-                              <Tag value="LowerIleum" />
-                              <Tag value="Mucosa" />
-                              <Tag value="SmallIntestineSegment" />
-                            </Tags>
-                            <Children>
-                              <Parameter id="EtTYjkCQJEOn0gocCOc0qQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                              <Parameter id="5T9P-wz7YE6eubvouXCiWQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="AWSLB9BqIUm588s01h4uMw" visible="1" canBeVaried="1" displayUnit="l" />
-                              <MoleculeAmount id="0cutZov5eEiqqp_uiBzdtw" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                                <Children>
-                                  <Parameter id="wN72NHgmD0un-PVUECVp-Q" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                                  <Parameter id="dtuy9_eSrk2oETfkotgnew" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IP_3Ta4i-EO1lQ8xR1RW2g" visible="0" canBeVaried="0" />
-                                  <Observer id="M_A5Lqly80CYNOSHhT9QWw" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
-                                </Children>
-                              </MoleculeAmount>
-                            </Children>
-                          </Container>
-                          <Container id="NNtCjKsDKEmpfBZtoykFkw" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                            <Tags>
-                              <Tag value="LowerIleum" />
-                              <Tag value="Mucosa" />
-                              <Tag value="SmallIntestineSegment" />
-                            </Tags>
-                            <Children>
-                              <Parameter id="jrwZLZ441EeO8kzLOZiZ_A" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                              <Parameter id="CarNZfZBJkuErb9nitIbJg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="bFSKBq9P6ESwCQ7kJZpF0A" visible="1" canBeVaried="1" displayUnit="l" />
-                              <MoleculeAmount id="o1HQX8-RRUmWuRf1rvmfuA" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                                <Children>
-                                  <Parameter id="zbCTiXqmHU6qo3fjE6r8VQ" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                                  <Parameter id="34G8bkW0rU68q-vtBVXpig" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="fjnww3ESJUq1tV2PgUACIA" visible="0" canBeVaried="0" />
-                                  <Observer id="nDrpcHH3o0CcOfRAm-nA1Q" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
-                                </Children>
-                              </MoleculeAmount>
-                            </Children>
-                          </Container>
-                          <Container id="uqiskikve0-qI31H7jOgWg" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                            <Tags>
-                              <Tag value="LowerIleum" />
-                              <Tag value="Mucosa" />
-                              <Tag value="SmallIntestineSegment" />
-                            </Tags>
-                            <Children>
-                              <Parameter id="l2gAhcuo2EmtoyZQ5dQuPQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                              <Parameter id="2hoiMvy5UUyZDa6uxcZbMQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="5D8ZOzXK7EGOwj3jJsZ67w" visible="1" canBeVaried="1" displayUnit="l" />
-                              <Parameter id="73Zmf_ZEIkyutXB2jI4XVw" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="mmPlMPjMnECVqmG5mkXJMw" visible="1" canBeVaried="1" />
-                              <MoleculeAmount id="RRkRhMuE70C8xM04dgNTkw" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                                <Children>
-                                  <Parameter id="PqK68-i4WU2arnJYsbDLrw" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                                  <Parameter id="aF9vLUzc202iJlBeDkd9bg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="dIewFJV8rkebXxIcP9r2mw" visible="0" canBeVaried="0" />
-                                  <Observer id="penbVSlVuUW9rEMtsVHiiw" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
-                                </Children>
-                              </MoleculeAmount>
-                            </Children>
-                          </Container>
-                          <Container id="sI2lB80kS0qpJ8_ruusBLA" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                            <Tags>
-                              <Tag value="IntestinalSecretionSource" />
-                              <Tag value="LowerIleum" />
-                              <Tag value="Mucosa" />
-                              <Tag value="SmallIntestineSegment" />
-                            </Tags>
-                            <Children>
-                              <Parameter id="mZ14VGKlFk-bCNtGnre06Q" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="dE28EI6hVk23fUjk1luoMw" visible="0" canBeVaried="0" displayUnit="l" />
-                              <Parameter id="1yrTgkgAUEiBDYGLQ1xtMA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="m5gWJCaKR0mYkdrFJN9OsQ" visible="1" canBeVaried="1" displayUnit="l" />
-                              <Parameter id="MN__K8Sd9kG7UexF5O2dqw" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.3" />
-                              <MoleculeAmount id="2dcifeUtpkujhqGqlE3Qnw" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                                <Children>
-                                  <Parameter id="DI67SpONC0uremPELE_OhA" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                                  <Parameter id="IYoz7-UTSkaRQXW7jDKi8Q" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Lw5BgQyUiEGMocKoIKUFbg" visible="0" canBeVaried="0" />
-                                  <Observer id="gnYk_gW07kq7yrxk7i2Ohg" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
-                                </Children>
-                              </MoleculeAmount>
-                            </Children>
-                          </Container>
-                        </Children>
-                      </Container>
-                    </Children>
-                  </Container>
-                  <Container id="A_wINMWnN0W8pazdejYTFg" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Observer id="Jdw70gQ9rUCh133N9hhjZg" name="Interstitial Unbound" description="Interstitial Unbound" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="ZyvJ8fAke0mbYrfSrxcACw" displayUnit="µmol/l" />
-                      <Observer id="l7vmcUI27kKYij90tmnJ3A" name="Intracellular Unbound" description="Intracellular Unbound" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="lHCXjnyQt0Wf_kfsvc1dyw" displayUnit="µmol/l" />
-                      <Observer id="huJvi_gS60SC51EFoMjcPw" name="Total Tissue (Small Intestine)" description="Mucosa and nonmucosa tissue" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="56ALDO1PPEaWXwRwJCty7Q" displayUnit="µmol/l" />
-                    </Children>
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-                </Children>
-              </Container>
-              <Container id="po_gtzNnlUusCPTspKCZOA" name="LargeIntestine" description="LargeIntestine" icon="LargeIntestine" mode="Logical" containerType="Organ">
-                <Tags>
-                  <Tag value="Portal Vein Supplying Organ" />
-                  <Tag value="TissueOrgan" />
-                </Tags>
-                <Children>
-                  <Parameter id="KJ5QF88zAEe2Yr_Mp0hTTA" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="uSjt8LuoBUu75Z4-7ZUOCw" visible="0" canBeVaried="1" displayUnit="kg" />
-                  <Parameter id="7w8cJG-FSESe2crE7AjWUw" name="Volume (mucosa)" description="Volume of mucosa" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="gMkJPynOskSVvu68YhL01A" visible="1" canBeVaried="1" displayUnit="l" />
-                  <Parameter id="EpM0eUkQCE-TrctPt9B9Kw" name="Large intestinal transit time factor" description="Large intestinal transit time factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="F485a5dR20-QtTuqFrMsaw" visible="0" canBeVaried="1" />
-                  <Parameter id="RC1cGQOd2U-emwNJH4hGxA" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="P-n1FKFwZk-Z6_CIrtgKiw" visible="1" canBeVaried="0" displayUnit="l/min" />
-                  <Parameter id="1Nf4MYN7u0WG-Mu3kv9MfA" name="Fluid recirculation flow rate (incl. mucosa)" description="Fluid recirculation flow rate between plasma and interstitial space (incl. mucosa)" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="mJJHlRTSNkmnisAFp0vU0g" visible="1" canBeVaried="1" displayUnit="l/min" />
-                  <Parameter id="5qGo1D4E_kisfgPVIP4MbQ" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="o-c90HQfc0Gbn3yuK2d4KA" visible="1" canBeVaried="0" displayUnit="l/min" />
-                  <Parameter id="YFSI7dgfhk6NhWLaDo01dg" name="Lymph flow rate (incl. mucosa)" description="Lymph flow rate (incl. mucosa)" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Yz3UrPPwck-1Ng_Y6QeNCg" visible="1" canBeVaried="1" displayUnit="l/min" />
-                  <Parameter id="1ypem1ZwfE-tHzAkT9d1xA" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="iGPeHxTV80WINhMPGzT1gQ" visible="1" canBeVaried="0" displayUnit="l" />
-                  <Parameter id="hq7oAtmEsEa7rKVSVWKhiw" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="LSHvGCmOBEascdPo-Ab-KQ" visible="1" canBeVaried="1" />
-                  <Parameter id="7mfq-KqvPU29gc_9wV67VA" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="jdhhCNoMYE-s118HG9XzZw" visible="1" canBeVaried="1" displayUnit="l/min" />
-                  <Parameter id="U-HkRWyXJkCRDKPZzK0afw" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                  <Parameter id="_kKmkgsd-0e6s2K7cqt54A" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.75" />
-                  <Parameter id="A5xyGtA2JUCEkWKSEpfYDQ" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                  <Parameter id="mDi0mc-NIUmJ7e6sfXF4IA" name="Mucosa blood flow fraction" description="Blood fraction which goes to mucosa" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.75" />
-                  <Parameter id="YHBUslOlWEClr5YTPxV2dw" name="Large intestinal transit time factor slope" description="Large intestinal transit time factor slope" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" visible="0" canBeVaried="0" value="0.938" displayUnit="1/min" />
-                  <Parameter id="VCNJawsPCUqOLL8wolSHgw" name="Large intestinal transit time factor intercept" description="Large intestinal transit time factor intercept" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="0" value="47.6" />
-                  <Parameter id="vmb2St8LSkW3RQnGrUVm1Q" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="4.5E-08" displayUnit="µm" />
-                  <Parameter id="vUp-R1Buq0WdxjGVpjdXWA" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="2.5E-07" displayUnit="µm" />
-                  <Parameter id="BHneLhAK90W1TzP-jge4Hw" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.05" />
-                  <Parameter id="z7GeacEJtU2aToicpfqeAQ" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" visible="1" canBeVaried="1" value="1.86944444444444E-10" displayUnit="ml/min/N" />
-                  <Parameter id="p5erebVP5k-cnfYcMzhWzQ" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.062" />
-                  <Parameter id="Umd-tyV4pEagvkSMuFi-Ig" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0487" />
-                  <Parameter id="xlSQ9fk5QECSI0Tnii_myw" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.024" />
-                  <Parameter id="VCXiFc1diEOW6CC1C0v7Ug" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.133" />
-                  <Parameter id="sWWGm28bDky2X1upG92Vrg" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0163" />
-                  <Parameter id="0_omnZXT1kOCOd1Fq8XWlQ" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.141" />
-                  <Parameter id="CgKr-qFZZk2IEcTsqb-nEA" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.718" />
-                  <Parameter id="ZpHozClTy0CQODyeEgsTCw" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.792" />
-                  <Parameter id="-Op-H-j3N0-pqVtmDqRznA" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.158" />
-                  <Parameter id="ItHxzFykxEuJEduVL8XZ0w" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-                  <Parameter id="e8UvFApvika_3VrI5ZaUUg" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.094" />
-                  <Parameter id="5lDR6f79JE6yyecMAJx-og" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0483" />
-                  <Parameter id="0fY1kp53pEOvuz8W6XfoYw" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0375" />
-                  <Parameter id="v49Swu4rKESA3P4x28FJ_Q" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0182" />
-                  <Parameter id="4sBj9Icatku3AMKzZKSRig" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0124" />
-                  <Parameter id="CwWCJYweKk6dV6_bckm-rQ" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.282" />
-                  <Parameter id="NzrK5qY3IkK1jQSVNSBXCA" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.15" />
-                  <Parameter id="zb6TZolYhEuyxLnxxwgkKw" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.456" />
-                  <Parameter id="BQpErpsGRkeYnQg0BkYkbA" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.78" />
-                  <Parameter id="tENHr93wp0mVn3L2a1AVeg" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="2.41" />
-                  <Parameter id="KRprie7bBk-4f9jwYQp7WA" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0035" />
-                  <DistributedParameter id="2_gW9d8VZ0ywO_d26OV5Lg" name="Large intestinal transit time" description="The time required for the passage of a non-absorbable compound through the large intestine, defined as the time span between small intestinal transit (i.e. the point at which 90% of the drug mass has entered the caecum) and the time at which 70% is excreted into feces" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" formula="2HUhd-FIGUC6noInuklctQ" mode="Logical" visible="1" displayUnit="h">
-                    <Children>
-                      <Parameter id="exW_I7HiVki6F-UNSgKrmg" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" displayUnit="h" />
-                      <Parameter id="-Wr5Tu-VakKbTrIngc-Fvw" name="Mean" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" visible="0" canBeVaried="1" value="2652" displayUnit="h" />
-                    </Children>
-                  </DistributedParameter>
-                  <DistributedParameter id="7m-C633c7UeAbdl9WuQPrw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="z0J0EfbiwkW_wC-Wi2XaoQ" mode="Logical" visible="1" displayUnit="l">
-                    <Children>
-                      <Parameter id="Thu3eZ5zk0aaWpgg9t-wdQ" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.501896001506457" displayUnit="l" />
-                      <Parameter id="4CsB4jmbm0igdsVajzjWIA" name="Mean" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" value="0.332056702440576" displayUnit="l" />
-                      <Parameter id="Qz_C1qipl0qMPEfofJsJOw" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0649145074993143" displayUnit="l" />
-                    </Children>
-                  </DistributedParameter>
-                  <DistributedParameter id="i9evrX0Jqky-3uMT2stZpA" name="Specific blood flow rate" description="Blood flow rate normalized to the organ volume" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" formula="1Gq_XZ94xEyvjAsvYSnmzA" mode="Logical" visible="1" displayUnit="ml/min/100g organ">
-                    <Children>
-                      <Parameter id="iZtOVR0Sekm-akhAJa0Xjw" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" displayUnit="ml/min/100g organ" />
-                      <Parameter id="ea0GkOvAZ0GoEOULT0dkhg" name="Mean" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" visible="0" canBeVaried="1" value="0.6305" displayUnit="ml/min/100g organ" />
-                      <Parameter id="vBm1SrkXi0mgw_z_iTHUVw" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" visible="0" canBeVaried="1" value="0.031525" displayUnit="ml/min/100g organ" />
-                    </Children>
-                  </DistributedParameter>
-                  <Container id="uvQs1PS9aUqsBpd5BT5HkA" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="LargeIntestine" />
-                      <Tag value="Portal Vein Supplying Organ" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="zln7PPZdSUKB7xs6IFAyhw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="l9NO7fMdYUOxGylLVw7_lA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="2znHM-7hCESyDJPFkFbbsw" visible="1" canBeVaried="1" displayUnit="l" />
-                      <MoleculeAmount id="xpcrmRU34EqRDnqQj6ZOeA" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                        <Children>
-                          <Parameter id="7dJDyexJ6UOTQEQnBmqMPg" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                          <Parameter id="t2lW2EPri065K58qeLah-w" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="upCvbO3rb0iMk20bR10Siw" visible="0" canBeVaried="0" />
-                          <Observer id="t_OWWUz2e0S5QfxzhDbs5g" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
-                        </Children>
-                      </MoleculeAmount>
-                    </Children>
-                  </Container>
-                  <Container id="SXH64aI-W0uPsXU5nSDPlA" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="LargeIntestine" />
-                      <Tag value="Portal Vein Supplying Organ" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="_rXQVE_a3Umj9-_vZzR5tg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="f3nC9WUl102v5NR_Of8G3w" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="iiR-BhU-e0i9WlcPjQsNdg" visible="1" canBeVaried="1" displayUnit="l" />
-                      <MoleculeAmount id="1CoHmlwfmEyD48lxr-SSNg" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                        <Children>
-                          <Parameter id="Y7hhm-gcJ0q07ezRW3Ns2A" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                          <Parameter id="d1OTGOlrWEuilBUHDUElhw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="aHEqPSvPGEGjT0bcYQY8GQ" visible="0" canBeVaried="0" />
-                          <Observer id="oYoofiUxrUu6ap1exYicTQ" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
-                        </Children>
-                      </MoleculeAmount>
-                    </Children>
-                  </Container>
-                  <Container id="3CzsBUOdUEOwjbwyWnTvGw" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="LargeIntestine" />
-                      <Tag value="Portal Vein Supplying Organ" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="iWpO7_FWt0SkJ3i9_qe5SA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="qSuUHGZZqU6VwQ_JDa_tIw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="8PysAt2r-Uuae7YiFGiTNQ" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Parameter id="z8m011nKGES3xUH0jzPBJw" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="mmPlMPjMnECVqmG5mkXJMw" visible="1" canBeVaried="1" />
-                      <MoleculeAmount id="ogyOwK65X0uL1DkZot3EUA" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                        <Children>
-                          <Parameter id="u1qpQpsYxUurDCnFKv415Q" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                          <Parameter id="g2IFaqY24ku5vGbhS0a8TA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="uCXhdhN0ckiQRwRoTYBcVQ" visible="0" canBeVaried="0" />
-                          <Observer id="9b7tS4tb-0S0z80GZvIVMQ" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
-                        </Children>
-                      </MoleculeAmount>
-                    </Children>
-                  </Container>
-                  <Container id="L1hfYmVZFU-7jRahk4WjGQ" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                    <Tags>
-                      <Tag value="LargeIntestine" />
-                      <Tag value="Portal Vein Supplying Organ" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="-m52w6hmDEGLIEgpmXw17w" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="YcDySoEECUCkabMfcgVuzw" visible="0" canBeVaried="0" displayUnit="l" />
-                      <Parameter id="JxZanPxAikmKij4sqCPCoQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="Ue-GxIfM90qPHZMmN2fUlw" visible="1" canBeVaried="1" displayUnit="l" />
-                      <Parameter id="iJCEtNGzWEy1rdY-aXZYlA" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.4" />
-                      <MoleculeAmount id="-Vdyhy1qAEGZJkWudpNPKA" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                        <Children>
-                          <Parameter id="4WBtFndYHE22fnESds_lgg" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                          <Parameter id="WxaNfeyvVUWsp9jybCm0-w" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="A_IOro_WwEu1O72l6SplmA" visible="0" canBeVaried="0" />
-                          <Observer id="LF7dgOurt0KKhfWKnObKkQ" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
-                        </Children>
-                      </MoleculeAmount>
-                    </Children>
-                  </Container>
-                  <Container id="6iYwon_rPU2TR8HIJazMpg" name="Mucosa" description="Mucosa" mode="Logical" containerType="Compartment">
-                    <Children>
-                      <Container id="hznOOD5ynUKXeXntSXnYrQ" name="Caecum" description="Cecum" icon="Caecum" mode="Logical" containerType="Compartment">
-                        <Children>
-                          <Parameter id="aZ0NZFvD1k2IaAxIX2a9Bg" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="uSjt8LuoBUu75Z4-7ZUOCw" visible="0" canBeVaried="1" displayUnit="kg" />
-                          <Parameter id="Nu9ZL0VRUEiKwYGp_ghkgg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="v5wmJnBiz0mTtk-ar-SUKw" visible="1" canBeVaried="1" displayUnit="l" />
-                          <Parameter id="eSwf5gouDUKKjtsjZQv56A" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="lLfXRJbfUkGeKcY-iG1hzQ" visible="1" canBeVaried="0" displayUnit="l" />
-                          <Parameter id="KOunUE0kg0mSlIsZI99Zig" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="NxoV47Ql00aifPKqk7nOJw" visible="1" canBeVaried="1" displayUnit="l/min" />
-                          <Parameter id="bO16AA0M1ES6kJ00P-HJCw" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="et1rku1VQkqZCxraRd0LsA" visible="1" canBeVaried="1" displayUnit="l/min" />
-                          <Parameter id="2pnwkl1hHUaFO7EJZ-cUPg" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="cDO00dCgEUa1Rf_VnhA32g" visible="1" canBeVaried="1" displayUnit="l/min" />
-                          <Parameter id="GOV-2O79CUuq2TreVgyl-w" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="LSHvGCmOBEascdPo-Ab-KQ" visible="1" canBeVaried="1" />
-                          <Parameter id="KVKt9TkOQ02o-5h0lOEybg" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                          <Parameter id="Mw8kJ05DuUuwfktvP35mkQ" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                          <Parameter id="Bc5wsBSEO0a_-3nGrep66A" name="Fraction of regional blood flow rate" description="Regional blood flow fraction supplying the mucosal tissue of the segment" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.084706" />
-                          <Parameter id="OTdxqtqFhUe8rVI3h8tJ9Q" name="Fraction mucosa" description="Mucosal fraction of regional intestinal tissue mass" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.19" />
-                          <Parameter id="HG-n4Kiy9ECavG6NWh68jQ" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="4.5E-08" displayUnit="µm" />
-                          <Parameter id="2AiLbHTkbku4tUMj9I3r6w" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.05" />
-                          <Parameter id="a6tBvx-XLE--Mh_JH4n8AA" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="2.5E-07" displayUnit="µm" />
-                          <Parameter id="4iTjAQFyCUaGyJVEk02krg" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" visible="1" canBeVaried="1" value="1.86944444444444E-10" displayUnit="ml/min/N" />
-                          <Parameter id="DnczRCBQjUyOva4xMzhe7g" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0487" />
-                          <Parameter id="v17BHzlzlEGhTCLiFF6WXA" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.06" />
-                          <Parameter id="3QgVAfTWxkCvKW1AIzgCtw" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.13" />
-                          <Parameter id="NLeAD0g7fUSDvqA--nm_5A" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.08" />
-                          <Parameter id="-Ot8aO3k30eTlj0nkC2Qtw" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0163" />
-                          <Parameter id="wkCeHunQ40SLaYni0YfPtA" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.718" />
-                          <Parameter id="XoeqKfUvF0COLOseSxn2-g" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.141" />
-                          <Parameter id="Pj6cKyyZt02GVRaf0gy3Ig" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.8" />
-                          <Parameter id="bVyxSQaAHEug9zVibLwgKw" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.158" />
-                          <Parameter id="YlFicvJOPU-uninqIdbmrQ" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-                          <Parameter id="CAoMfbg2lUuiYaTbTB2GNg" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.73" />
-                          <Parameter id="hWGbH8QIDUO0crbVtCqmpA" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0483" />
-                          <Parameter id="usYPbtEMt0Czgz8ZmisvMw" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0375" />
-                          <Parameter id="8zNVnt81tkOEp32C_MiJwg" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0124" />
-                          <Parameter id="hmLsF86eEkevVLT-p7Ntgg" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0182" />
-                          <Parameter id="ktzONXAtMU6A7a6_xwWy-A" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.282" />
-                          <Parameter id="SMpok1ovl0eWQTuiNjWTfw" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.15" />
-                          <Parameter id="cWJAhjAbtke-EJIU1mY3yw" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.456" />
-                          <Parameter id="AjsZle9_t0y9xBllxHuovw" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.78" />
-                          <Parameter id="ayLV1MAMM0usJnsyGaDHdg" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0035" />
-                          <Parameter id="iBazNAwIOkaCF5WbIHGz_g" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="2.41" />
-                          <Container id="qk0qF8uZI06cnoMMMXTreA" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                            <Tags>
-                              <Tag value="Caecum" />
-                              <Tag value="LargeIntestineSegment" />
-                              <Tag value="Mucosa" />
-                            </Tags>
-                            <Children>
-                              <Parameter id="lAWPvAKldEyN9MBBTkpfMg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                              <Parameter id="oo5_XCmusEmO-vQW04mT2w" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="AWSLB9BqIUm588s01h4uMw" visible="1" canBeVaried="1" displayUnit="l" />
-                              <MoleculeAmount id="Lpte9WeV50K2AalO8MrxAw" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                                <Children>
-                                  <Parameter id="5AwX1H6TC0maWvlD_hcYvQ" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                                  <Parameter id="1cVzMgMcA0qnbiaVQs7ZWg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="xlQsWe6fu0KgXTipRA2F5Q" visible="0" canBeVaried="0" />
-                                  <Observer id="pGd1sItJnUaX5y0aDHB_bw" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
-                                </Children>
-                              </MoleculeAmount>
-                            </Children>
-                          </Container>
-                          <Container id="6kGZy_3g3U-NktadHdhW3Q" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                            <Tags>
-                              <Tag value="Caecum" />
-                              <Tag value="LargeIntestineSegment" />
-                              <Tag value="Mucosa" />
-                            </Tags>
-                            <Children>
-                              <Parameter id="aEbAcsGXukqmSayW8AYClA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                              <Parameter id="IBuAvwKQd0yqKTUpkNsbgQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="bFSKBq9P6ESwCQ7kJZpF0A" visible="1" canBeVaried="1" displayUnit="l" />
-                              <MoleculeAmount id="05yORl8O3EeGbBTdKhAhHA" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                                <Children>
-                                  <Parameter id="0FmvhckWmUippjyxRi0aCg" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                                  <Parameter id="umtR6uj9NEi_Ir6paNWVgg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="W6FdArXtR0eSm3wKoZGYfA" visible="0" canBeVaried="0" />
-                                  <Observer id="PTpBR5iMOk6xQxDpKJvQ2g" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
-                                </Children>
-                              </MoleculeAmount>
-                            </Children>
-                          </Container>
-                          <Container id="3hhWlW8CU02dQMHm8E1PTg" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                            <Tags>
-                              <Tag value="Caecum" />
-                              <Tag value="LargeIntestineSegment" />
-                              <Tag value="Mucosa" />
-                            </Tags>
-                            <Children>
-                              <Parameter id="QUyRKS7AmU26Hq5Kz2nAKw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                              <Parameter id="PEBwXgx9_k-BZ_7_rcW1vg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="5D8ZOzXK7EGOwj3jJsZ67w" visible="1" canBeVaried="1" displayUnit="l" />
-                              <Parameter id="Wx53-EuqP0CIhQDjqQ0mXQ" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="mmPlMPjMnECVqmG5mkXJMw" visible="1" canBeVaried="1" />
-                              <MoleculeAmount id="CNB35o9wBEK0VIuxxircsA" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                                <Children>
-                                  <Parameter id="loWQ-9nEQ0OvSmBc4EBCfw" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                                  <Parameter id="VSVBUguZck-r22IZj77ltg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="whqdmHrWs0yRUbkr-1qkrg" visible="0" canBeVaried="0" />
-                                  <Observer id="TAG0PxlmiUKxgkrj3vmllA" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
-                                </Children>
-                              </MoleculeAmount>
-                            </Children>
-                          </Container>
-                          <Container id="t-B68_pEAUyLs_Kjh2XotQ" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                            <Tags>
-                              <Tag value="Caecum" />
-                              <Tag value="IntestinalSecretionSource" />
-                              <Tag value="LargeIntestineSegment" />
-                              <Tag value="Mucosa" />
-                            </Tags>
-                            <Children>
-                              <Parameter id="vpLsvSm-h06lVO2WhvjTjQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="dE28EI6hVk23fUjk1luoMw" visible="0" canBeVaried="0" displayUnit="l" />
-                              <Parameter id="DwOXxCI74Uu2j53YVPkyiA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="m5gWJCaKR0mYkdrFJN9OsQ" visible="1" canBeVaried="1" displayUnit="l" />
-                              <Parameter id="HTShN6IUYEqAL9wmFlnnSA" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.3" />
-                              <MoleculeAmount id="gaxUc91cjECJ7Oyx20_0iw" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                                <Children>
-                                  <Parameter id="-9NtwEo1ZkmHdgdxeTIJoA" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                                  <Parameter id="MUIP2PoUi0qYvaTZ4lSeqg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Dw-eIrIp1kq-_Cuz8PZjPw" visible="0" canBeVaried="0" />
-                                  <Observer id="mAlpyQT_VUKeM3PXvnpsMA" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
-                                </Children>
-                              </MoleculeAmount>
-                            </Children>
-                          </Container>
-                        </Children>
-                      </Container>
-                      <Container id="jtzoNNW17EezzLh8Xeawsw" name="ColonAscendens" description="Colon Ascendens" icon="ColonAscendens" mode="Logical" containerType="Compartment">
-                        <Children>
-                          <Parameter id="Y2PQfq-Mck-Ie3xCfs7tNA" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="uSjt8LuoBUu75Z4-7ZUOCw" visible="0" canBeVaried="1" displayUnit="kg" />
-                          <Parameter id="PWr_f9XeS0uH45-1spwwFA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="sHDXa0deUUOJ9tdxgBtmQA" visible="1" canBeVaried="1" displayUnit="l" />
-                          <Parameter id="lAM_Mw9oBkGMWeCZ2aEZSw" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="qp9GXwt6rkOqY42IUZXfzA" visible="1" canBeVaried="0" displayUnit="l" />
-                          <Parameter id="0wrNVFYvdk6wJkKei1Re8A" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="NxoV47Ql00aifPKqk7nOJw" visible="1" canBeVaried="1" displayUnit="l/min" />
-                          <Parameter id="DyzAsI-8ckaWyTi0CbTZ1g" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="et1rku1VQkqZCxraRd0LsA" visible="1" canBeVaried="1" displayUnit="l/min" />
-                          <Parameter id="IXmWIBeOmU-GWiZ8QqyH_g" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="cDO00dCgEUa1Rf_VnhA32g" visible="1" canBeVaried="1" displayUnit="l/min" />
-                          <Parameter id="CFrGjf2OoEGDa7P8ruEBbw" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="LSHvGCmOBEascdPo-Ab-KQ" visible="1" canBeVaried="1" />
-                          <Parameter id="3kAeZtmfnUCz-bU2KIqXFg" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                          <Parameter id="CwE547flbkahr_1MUZspvw" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                          <Parameter id="02iq__qJGUKb28UncN3_Dw" name="Fraction mucosa" description="Mucosal fraction of regional intestinal tissue mass" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.19" />
-                          <Parameter id="MlqY7ebkZk2S0UCsLnPNlQ" name="Fraction of regional blood flow rate" description="Regional blood flow fraction supplying the mucosal tissue of the segment" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.15529" />
-                          <Parameter id="Rbzhsvdqxkq8KyY8uxg-_w" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="4.5E-08" displayUnit="µm" />
-                          <Parameter id="Eem945_6-kWIzmL7nMMyVg" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="2.5E-07" displayUnit="µm" />
-                          <Parameter id="6mlWbQhFr0C9iwE0OljbhA" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" visible="1" canBeVaried="1" value="1.86944444444444E-10" displayUnit="ml/min/N" />
-                          <Parameter id="pVgX4Q2W10m11Wdv_2N_Hg" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.05" />
-                          <Parameter id="aTEPIbXUgEe4QnJAZCPS9w" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.06" />
-                          <Parameter id="F-Cw9LjUxUSJ_1QjK_XPSA" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0487" />
-                          <Parameter id="_ngP5p1y2ESzwX9oExTFIQ" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.13" />
-                          <Parameter id="ZUyqgC3560au7M6w75umCQ" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.08" />
-                          <Parameter id="Ue6JVjFtxEK81Gm6-ALc7A" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0163" />
-                          <Parameter id="l3vjuHn5UkyM-yZ70dgyQg" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.141" />
-                          <Parameter id="aJDm-V_Yak-GqksaSg9cWA" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.158" />
-                          <Parameter id="At7GrBrx1k-AYK8NfqwKQQ" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-                          <Parameter id="JON-wlHVgEygaZsMp9Qplw" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.718" />
-                          <Parameter id="UzeVxtsqqUmKiuHVEq4jaA" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.8" />
-                          <Parameter id="UmasU7CkgU6D9dFV2xVHjw" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.73" />
-                          <Parameter id="dkGdMXUViEyivQ2sbsuM8g" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0483" />
-                          <Parameter id="kmQXgTbvXkmyEAMaWjS-iw" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0375" />
-                          <Parameter id="qZ7GdJ1X1kCy6N7KSn0Qqw" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0182" />
-                          <Parameter id="ZzIWX8Gl1US7D7qBTwZVkA" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0124" />
-                          <Parameter id="eAr3TX97iEqWN981-gbcGg" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.15" />
-                          <Parameter id="J87uv3v2zkW9ZAO1FDaFKg" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.282" />
-                          <Parameter id="LFKPxFGujEq0fhTpfNz2cA" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.456" />
-                          <Parameter id="ZQEBHRFSV067aTSsqqb8yA" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.78" />
-                          <Parameter id="sMejWd-0G0eDT3t4VZo_3w" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="2.41" />
-                          <Parameter id="gxb2F_fvU0yIbGVrLAHkOg" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0035" />
-                          <Container id="Aivr7qttHUatCWB0Vus_ew" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                            <Tags>
-                              <Tag value="ColonAscendens" />
-                              <Tag value="LargeIntestineSegment" />
-                              <Tag value="Mucosa" />
-                            </Tags>
-                            <Children>
-                              <Parameter id="hmsOd5GfEkaY8GuaDj_HjA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                              <Parameter id="K0jDEg31eUaHaHDDmYAujA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="AWSLB9BqIUm588s01h4uMw" visible="1" canBeVaried="1" displayUnit="l" />
-                              <MoleculeAmount id="0zNjwXhGpkSaSYQZC4yzdw" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                                <Children>
-                                  <Parameter id="MYF25tGLsEO19u5Jz69Hmg" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                                  <Parameter id="l8wnQmeoHUq3LyUBACIqfA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="4xTw7NGSPkS9Qn1bH3Tu8A" visible="0" canBeVaried="0" />
-                                  <Observer id="2pPu7riJyU66dbhQbxc1pw" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
-                                </Children>
-                              </MoleculeAmount>
-                            </Children>
-                          </Container>
-                          <Container id="-BbZRBaQ_EGB3LiH3qZ_Ag" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                            <Tags>
-                              <Tag value="ColonAscendens" />
-                              <Tag value="LargeIntestineSegment" />
-                              <Tag value="Mucosa" />
-                            </Tags>
-                            <Children>
-                              <Parameter id="3VkQg_UKq0OT7GlzqL5LnQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                              <Parameter id="ihf3BnE_7EWS8I-L5Sc6rA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="bFSKBq9P6ESwCQ7kJZpF0A" visible="1" canBeVaried="1" displayUnit="l" />
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-                                <Children>
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-                              <Tag value="LargeIntestineSegment" />
-                              <Tag value="Mucosa" />
-                            </Tags>
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-                              <Parameter id="FdfyL2ghK0CFRi_RKhe3aQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
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-                            <Tags>
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-                              <Tag value="IntestinalSecretionSource" />
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-                          <Parameter id="gb_0r5gMeU23-w8rYriudQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="Tfb9WXnJCkawvENV_l-g7w" visible="1" canBeVaried="1" displayUnit="l" />
-                          <Parameter id="Ms-uyeAysEmDB1iGZaAPAg" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="IMi1JmNuqUWjsGtRtUwn1A" visible="1" canBeVaried="0" displayUnit="l" />
-                          <Parameter id="1C5To3t8E0W5YMSWCHxVCA" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="et1rku1VQkqZCxraRd0LsA" visible="1" canBeVaried="1" displayUnit="l/min" />
-                          <Parameter id="HdXL_QbPjU-YxgKX6lO-kw" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="NxoV47Ql00aifPKqk7nOJw" visible="1" canBeVaried="1" displayUnit="l/min" />
-                          <Parameter id="ur074lkhuEyVE4EKaQUZAQ" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="cDO00dCgEUa1Rf_VnhA32g" visible="1" canBeVaried="1" displayUnit="l/min" />
-                          <Parameter id="4zvrbsjyeEuRmh8tbBSdFQ" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="LSHvGCmOBEascdPo-Ab-KQ" visible="1" canBeVaried="1" />
-                          <Parameter id="nfvVZxxdtEufPseiFEw5Fw" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                          <Parameter id="k2Vxhwt2TUiXQdvQkWcDcQ" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                          <Parameter id="OQ7JBuGASkeSfKOAhTyrAw" name="Fraction of regional blood flow rate" description="Regional blood flow fraction supplying the mucosal tissue of the segment" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.32" />
-                          <Parameter id="Buutm5YyA0y4AjZVz6Qaww" name="Fraction mucosa" description="Mucosal fraction of regional intestinal tissue mass" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.21" />
-                          <Parameter id="j6nItkJtykmOZAi-faN6Ow" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="4.5E-08" displayUnit="µm" />
-                          <Parameter id="etFybMFPeEWVI2foCbTExA" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="2.5E-07" displayUnit="µm" />
-                          <Parameter id="LTPpVsFG90G2PbdK9LJ5Lg" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" visible="1" canBeVaried="1" value="1.86944444444444E-10" displayUnit="ml/min/N" />
-                          <Parameter id="xRd4WrsvhEyI-2Ti6vDZuQ" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.05" />
-                          <Parameter id="nfFh4ZifekWINKDHPJTY1g" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.06" />
-                          <Parameter id="vDhK_5LylUeaFXsvMBekQg" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0487" />
-                          <Parameter id="EFr1IQddnEWQ7Xvr99XPnA" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.12" />
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-                          <Parameter id="sU6IC24I30aUcHDgaEBY-Q" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.08" />
-                          <Parameter id="ezFEpVuBQk2UfVyvXe_8Rw" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.158" />
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-                          <Parameter id="ERfE0E8YCku5myHxrjIbzw" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.141" />
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-                          <Parameter id="Az_mJy2y10CABrBzet9d0A" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="2.41" />
-                          <Parameter id="Z6_PRtXZyEK4v5007UGV1Q" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0035" />
-                          <Container id="-P41WVvf4kGpY92ttsK8NQ" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                            <Tags>
-                              <Tag value="ColonTransversum" />
-                              <Tag value="LargeIntestineSegment" />
-                              <Tag value="Mucosa" />
-                            </Tags>
-                            <Children>
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-                            <Tags>
-                              <Tag value="ColonTransversum" />
-                              <Tag value="LargeIntestineSegment" />
-                              <Tag value="Mucosa" />
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-                              <Parameter id="g2iHtbkYpU2wJWy2QOyPow" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                              <Parameter id="G-JN6euf2Uun6lP1i4xmpQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="bFSKBq9P6ESwCQ7kJZpF0A" visible="1" canBeVaried="1" displayUnit="l" />
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-                          <Container id="uSnfTCjzEEKsrn-SJCCw0g" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                            <Tags>
-                              <Tag value="ColonTransversum" />
-                              <Tag value="LargeIntestineSegment" />
-                              <Tag value="Mucosa" />
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-                              <Parameter id="nKYrREfQm0yzmw6snl3Nxg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
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-                                  <Parameter id="ocR4Ah6u3kGcY-cg3O5ojQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="QNdB6CbDZ0aPPpQntIjShQ" visible="0" canBeVaried="0" />
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-                            <Tags>
-                              <Tag value="ColonTransversum" />
-                              <Tag value="IntestinalSecretionSource" />
-                              <Tag value="LargeIntestineSegment" />
-                              <Tag value="Mucosa" />
-                            </Tags>
-                            <Children>
-                              <Parameter id="l6A1dp-fnUy3SNEaB80rSQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="dE28EI6hVk23fUjk1luoMw" visible="0" canBeVaried="0" displayUnit="l" />
-                              <Parameter id="dZVyQqzxKUuqHoxeGVCqxA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="m5gWJCaKR0mYkdrFJN9OsQ" visible="1" canBeVaried="1" displayUnit="l" />
-                              <Parameter id="e5YnD4tY-0CRq6NXmfZzTg" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.3" />
-                              <MoleculeAmount id="H0qyxGwyUkWmeHAlvjEj4w" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                                <Children>
-                                  <Parameter id="oQONFFJ07EWD8yN__-FU1A" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                                  <Parameter id="17v7eeaFWkeq5wiMbieSzQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="mOY_O9ElgEa82lAqEptlJw" visible="0" canBeVaried="0" />
-                                  <Observer id="P0-6oMraME2GC-pnJQenzA" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
-                                </Children>
-                              </MoleculeAmount>
-                            </Children>
-                          </Container>
-                        </Children>
-                      </Container>
-                      <Container id="Eyd-qA3B-Uibv5cS2nnbzQ" name="ColonDescendens" description="Colon Descendens / Distal Colon 1" icon="ColonDescendens" mode="Logical" containerType="Compartment">
-                        <Children>
-                          <Parameter id="oMhX48ArOk-RiJgOBV5eoQ" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="uSjt8LuoBUu75Z4-7ZUOCw" visible="0" canBeVaried="1" displayUnit="kg" />
-                          <Parameter id="dF5muo4BZUCsjl4SfyeARg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="3HlR5bC0I0ip9T2uJKueHQ" visible="1" canBeVaried="1" displayUnit="l" />
-                          <Parameter id="xgJApB0pYEmD2ysKQYJpcg" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="NxoV47Ql00aifPKqk7nOJw" visible="1" canBeVaried="1" displayUnit="l/min" />
-                          <Parameter id="HqiZMHyv3U2WSPP15tF_JA" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="et1rku1VQkqZCxraRd0LsA" visible="1" canBeVaried="1" displayUnit="l/min" />
-                          <Parameter id="ylRG6W_81Um9bI3czJiiUw" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="uaQ4VG7LJ0-FzyI6A0Kr9Q" visible="1" canBeVaried="0" displayUnit="l" />
-                          <Parameter id="3uuZcmB5iEiadr_a7irTGA" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="cDO00dCgEUa1Rf_VnhA32g" visible="1" canBeVaried="1" displayUnit="l/min" />
-                          <Parameter id="IZcI5q8nWkaqDsx-TgxhXg" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="LSHvGCmOBEascdPo-Ab-KQ" visible="1" canBeVaried="1" />
-                          <Parameter id="6Gb46hXvxkunrG3uy-Fswg" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                          <Parameter id="ydEcL4hE5keG51LcmwyCTg" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                          <Parameter id="RT22-6m-KEK1se5VOO9IXA" name="Fraction mucosa" description="Mucosal fraction of regional intestinal tissue mass" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.14" />
-                          <Parameter id="3RbsY-jqKU-4SL-EGjKhtQ" name="Fraction of regional blood flow rate" description="Regional blood flow fraction supplying the mucosal tissue of the segment" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.24" />
-                          <Parameter id="xLWr83m4R0O5uEe7yTDumw" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="4.5E-08" displayUnit="µm" />
-                          <Parameter id="D1bVnz8GekyYTiI-cAkPKg" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="2.5E-07" displayUnit="µm" />
-                          <Parameter id="LHrviWfm0UOUrlbXSXtr5Q" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" visible="1" canBeVaried="1" value="1.86944444444444E-10" displayUnit="ml/min/N" />
-                          <Parameter id="qE4jx49axUSlQVpMf-hRIA" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.05" />
-                          <Parameter id="tdAM33zCEE-5y5Lo6CBuhQ" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0487" />
-                          <Parameter id="8cikcBdz-0iUJUaa3adXiw" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.06" />
-                          <Parameter id="aYEtCTrMx0uOFdpCfamQWg" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.12" />
-                          <Parameter id="W2JYrvrs9E2Mh9zOuLABTQ" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.08" />
-                          <Parameter id="5nKRRiblq0O0FQA9_NtQOw" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0163" />
-                          <Parameter id="EwpUFYRkPEqyNW9w0S20oA" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.158" />
-                          <Parameter id="AdM5zlSFekeTpsr6fir4-w" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-                          <Parameter id="M7K9shuNaUWjLl-n74jr3Q" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.141" />
-                          <Parameter id="IqKBqPFRyEOx-GlADQiY1w" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.8" />
-                          <Parameter id="4AV-p5cNb0KTJi38bf7TGQ" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.718" />
-                          <Parameter id="xb8rrQYVV0uFKNArBDOKmQ" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.74" />
-                          <Parameter id="KYRmpZU8H0yrQNEOPcxQRQ" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0375" />
-                          <Parameter id="zOb1EhoSSkyvFePc5xnTxw" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0483" />
-                          <Parameter id="-sJW98pcsky59WFKEmGOrg" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0182" />
-                          <Parameter id="IxrZTUkGJUe9FzBOFw_-WQ" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0124" />
-                          <Parameter id="H6OvFBJUCE2UN3k9tjmUAg" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.15" />
-                          <Parameter id="9UBg6kqcnUiGKm8Rf3b-NA" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.282" />
-                          <Parameter id="BJaIybmMA0igJ8_JHhLyTQ" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.78" />
-                          <Parameter id="wv8dDY8PwUGjmWTJs5IGQw" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.456" />
-                          <Parameter id="ESKw249cBU2THiSd8dPqhw" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0035" />
-                          <Parameter id="jHymTXgNXUWtfyyVK9Tv6A" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="2.41" />
-                          <Container id="IYSOBD2MW0SByEccir1gtg" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                            <Tags>
-                              <Tag value="ColonDescendens" />
-                              <Tag value="LargeIntestineSegment" />
-                              <Tag value="Mucosa" />
-                            </Tags>
-                            <Children>
-                              <Parameter id="Y8c_LbS3xU-kbT79cDcgSw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                              <Parameter id="9jc4ZJ5nE0GM3HExiabjFQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="AWSLB9BqIUm588s01h4uMw" visible="1" canBeVaried="1" displayUnit="l" />
-                              <MoleculeAmount id="fRScY5akTkSbcR1hbKcs5Q" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                                <Children>
-                                  <Parameter id="HAjpLApo9kG8O3TP53Lt6g" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                                  <Parameter id="GqdxWGQlXEy8gSBrVJQqSg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="r_rg-1cyFEqdW6fn1578NA" visible="0" canBeVaried="0" />
-                                  <Observer id="6AXee4V_Q0SjGdh2YgPYfg" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
-                                </Children>
-                              </MoleculeAmount>
-                            </Children>
-                          </Container>
-                          <Container id="0Ysv4senlEeNmmozTIAQkw" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                            <Tags>
-                              <Tag value="ColonDescendens" />
-                              <Tag value="LargeIntestineSegment" />
-                              <Tag value="Mucosa" />
-                            </Tags>
-                            <Children>
-                              <Parameter id="74femimPT0SD6NkUeFxSow" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                              <Parameter id="rWBFdG5X_0mA0vlTBNiQow" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="bFSKBq9P6ESwCQ7kJZpF0A" visible="1" canBeVaried="1" displayUnit="l" />
-                              <MoleculeAmount id="3eMVtSbfykKuZmsiS31jUg" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                                <Children>
-                                  <Parameter id="DoTrykpCCEuQT-zn5LETDg" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                                  <Parameter id="Zgnn9mIvvkG4BTIdn6S5PQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="2OMBj4D3u06KMsuP9Ggi8w" visible="0" canBeVaried="0" />
-                                  <Observer id="kH-LrToJj0yv_afGX__Gag" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
-                                </Children>
-                              </MoleculeAmount>
-                            </Children>
-                          </Container>
-                          <Container id="YUV1KDlDvUS4N8X86jTR_w" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                            <Tags>
-                              <Tag value="ColonDescendens" />
-                              <Tag value="LargeIntestineSegment" />
-                              <Tag value="Mucosa" />
-                            </Tags>
-                            <Children>
-                              <Parameter id="BgEEIghq4USl7-BN95XfEQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                              <Parameter id="LB1FVxIN80OeQLJqvZnB_Q" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="5D8ZOzXK7EGOwj3jJsZ67w" visible="1" canBeVaried="1" displayUnit="l" />
-                              <Parameter id="znmOoQBHdEmplc7L2LGDPw" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="mmPlMPjMnECVqmG5mkXJMw" visible="1" canBeVaried="1" />
-                              <MoleculeAmount id="OTfVa-Dmd029ivqi8nkVCQ" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                                <Children>
-                                  <Parameter id="V5SO7AcXfkq0Hrb-Rs9riQ" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                                  <Parameter id="6LQKxx26U02hhrY5ux7KqA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="I5t2Ze3F-ECWlQKKQbdq5A" visible="0" canBeVaried="0" />
-                                  <Observer id="zwQZmmZJYEygJQF8QnKktA" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
-                                </Children>
-                              </MoleculeAmount>
-                            </Children>
-                          </Container>
-                          <Container id="yvx9mFVur0KdwvcmwHHcQw" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                            <Tags>
-                              <Tag value="ColonDescendens" />
-                              <Tag value="IntestinalSecretionSource" />
-                              <Tag value="LargeIntestineSegment" />
-                              <Tag value="Mucosa" />
-                            </Tags>
-                            <Children>
-                              <Parameter id="Ync0tUPUWESLFITHgm8T7w" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="dE28EI6hVk23fUjk1luoMw" visible="0" canBeVaried="0" displayUnit="l" />
-                              <Parameter id="w29kvM78a0KTOqDzvJKtQw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="m5gWJCaKR0mYkdrFJN9OsQ" visible="1" canBeVaried="1" displayUnit="l" />
-                              <Parameter id="XyNAVXhpXU6nSs9cd1SB2g" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.3" />
-                              <MoleculeAmount id="XdsPQQqfnU68je9V8z203Q" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                                <Children>
-                                  <Parameter id="PWGh8dGva0iLDfEg2K2FGw" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                                  <Parameter id="Y9eZ9u3qK0mK40GnAi7TPQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="VJgVVdT0c0Woc8nztDksNA" visible="0" canBeVaried="0" />
-                                  <Observer id="fHLh5Enm4U6Jbl9ssvW4Hw" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
-                                </Children>
-                              </MoleculeAmount>
-                            </Children>
-                          </Container>
-                        </Children>
-                      </Container>
-                      <Container id="We1fNhXFXk-g3c6l8NQf4w" name="ColonSigmoid" description="Colon Sigmoid / Distal Colon 2" icon="ColonSigmoid" mode="Logical" containerType="Compartment">
-                        <Children>
-                          <Parameter id="YnAhYso41Uaz2X8k-tNarQ" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="uSjt8LuoBUu75Z4-7ZUOCw" visible="0" canBeVaried="1" displayUnit="kg" />
-                          <Parameter id="42qB8xCXTkekpBAh-3Kwtg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="HdOxCAdxo0WbGvz4CigSwA" visible="1" canBeVaried="1" displayUnit="l" />
-                          <Parameter id="A1NN2XgKrU210C5Ho5tTdQ" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="NxoV47Ql00aifPKqk7nOJw" visible="1" canBeVaried="1" displayUnit="l/min" />
-                          <Parameter id="uHKN-b_QhUqOFIUA7LdKlw" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="et1rku1VQkqZCxraRd0LsA" visible="1" canBeVaried="1" displayUnit="l/min" />
-                          <Parameter id="amOV9R1vck6owViCqOA7Yg" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="d-TaC6E_QEO9RvMa9SWwHQ" visible="1" canBeVaried="0" displayUnit="l" />
-                          <Parameter id="LvwN2-ZsR06gVd_6JWSnlw" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="cDO00dCgEUa1Rf_VnhA32g" visible="1" canBeVaried="1" displayUnit="l/min" />
-                          <Parameter id="LR864pK-wUmrVTtdrJWp8w" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="LSHvGCmOBEascdPo-Ab-KQ" visible="1" canBeVaried="1" />
-                          <Parameter id="Fg-Avj5w7Ua5y_c1z9RsEA" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                          <Parameter id="ZAxnXZhkV0-D59cUrFkwFQ" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                          <Parameter id="VULFgHmP3ki041GqBwqL2g" name="Fraction of regional blood flow rate" description="Regional blood flow fraction supplying the mucosal tissue of the segment" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.135" />
-                          <Parameter id="N6-MLaBEPUG8MSED3iN8lA" name="Fraction mucosa" description="Mucosal fraction of regional intestinal tissue mass" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.3" />
-                          <Parameter id="CKt1pynpa0CjF9jltu4d_g" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="4.5E-08" displayUnit="µm" />
-                          <Parameter id="xE5nMkLvvkuxh-3FXMutWQ" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="2.5E-07" displayUnit="µm" />
-                          <Parameter id="EPqIYHXq30-p3zzL6R6TzA" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.05" />
-                          <Parameter id="O4SYnyBNvUaoFNILS2HhWg" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" visible="1" canBeVaried="1" value="1.86944444444444E-10" displayUnit="ml/min/N" />
-                          <Parameter id="_maCu93HKkKxnBEBdgGgbQ" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0487" />
-                          <Parameter id="GRFfjdVY0U-yqhlKl330Gw" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.06" />
-                          <Parameter id="OwwYyAs7Y0-0CdZpEVF0fQ" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.08" />
-                          <Parameter id="4WKt4pYtY0GUAhYRrCJS8Q" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0163" />
-                          <Parameter id="uvJJoJNuuECVav0i23QP9g" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.08" />
-                          <Parameter id="K2KnTcNgJECojbl6gO2fZQ" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.8" />
-                          <Parameter id="BaZNUzp5UEKcQhbLcPOEZQ" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.141" />
-                          <Parameter id="ILyit_uqHUKdPGMKU7u5ww" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.158" />
-                          <Parameter id="vXW8fxcDkUuWKNyZlCxGPg" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-                          <Parameter id="K8XKRD7EsEqkPG0ZGtXDwg" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.718" />
-                          <Parameter id="HcNmw3n9L0GxA-ee74vLWA" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.78" />
-                          <Parameter id="3yJHX1YqUkmWkmO0kY5ZPA" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0483" />
-                          <Parameter id="lqyNfw7IYkeRUeVqwELEAw" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0375" />
-                          <Parameter id="jFtMxQWQwEWTyXUh71Dzpg" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0124" />
-                          <Parameter id="N32ozzInakGyFZmjxxYvcw" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0182" />
-                          <Parameter id="a6T_UZUceEuBVmoYQm0fxg" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.15" />
-                          <Parameter id="lvVd-s3TuU2LQh8sr_FBQg" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.282" />
-                          <Parameter id="DFcEAxQBr02zbcP4REyCig" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.78" />
-                          <Parameter id="90gkAjcm_kaZt_iysl0yZg" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.456" />
-                          <Parameter id="d4V4mjWpiUKlNfAfcKn9KA" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="2.41" />
-                          <Parameter id="qyFSL_Z7oEya_oWv9b3Vng" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0035" />
-                          <Container id="bzYLFyk2JkmtP6F5xOz6QQ" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                            <Tags>
-                              <Tag value="ColonSigmoid" />
-                              <Tag value="LargeIntestineSegment" />
-                              <Tag value="Mucosa" />
-                            </Tags>
-                            <Children>
-                              <Parameter id="mBp2PZ3oBk6c7luzMCpF6g" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                              <Parameter id="cegg3V6oSEejO_V01i7b9Q" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="AWSLB9BqIUm588s01h4uMw" visible="1" canBeVaried="1" displayUnit="l" />
-                              <MoleculeAmount id="xTGJR_rEKE6vG1pK_dnKhA" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                                <Children>
-                                  <Parameter id="H-8tY_B9ykaueSRVT1iu9A" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                                  <Parameter id="vjSQR8_MqUiYOe5hPFDhvQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="sfbJhewAsEavS48Fioa7Kg" visible="0" canBeVaried="0" />
-                                  <Observer id="VmVB_K0S7kix4q98FPSftg" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
-                                </Children>
-                              </MoleculeAmount>
-                            </Children>
-                          </Container>
-                          <Container id="96RIWxzJSUmdHw6J1qxOyw" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                            <Tags>
-                              <Tag value="ColonSigmoid" />
-                              <Tag value="LargeIntestineSegment" />
-                              <Tag value="Mucosa" />
-                            </Tags>
-                            <Children>
-                              <Parameter id="368p-3J9M0O_2GeZSti99A" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                              <Parameter id="S3xCZ1otKUqM04FojSd6PQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="bFSKBq9P6ESwCQ7kJZpF0A" visible="1" canBeVaried="1" displayUnit="l" />
-                              <MoleculeAmount id="nPc7HZ7onEeWVXA5yaAQVg" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                                <Children>
-                                  <Parameter id="T3J5p9TNqkCCaWxAjqveLg" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                                  <Parameter id="XbR3wG83PU2bCcCpIvakHA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="PBgH45rwxUy4jRl2YGMd8g" visible="0" canBeVaried="0" />
-                                  <Observer id="uWEddUWZ0Uy31qUi3CfC1Q" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
-                                </Children>
-                              </MoleculeAmount>
-                            </Children>
-                          </Container>
-                          <Container id="5HpeQ-ekKkOS2la6bazFiA" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                            <Tags>
-                              <Tag value="ColonSigmoid" />
-                              <Tag value="LargeIntestineSegment" />
-                              <Tag value="Mucosa" />
-                            </Tags>
-                            <Children>
-                              <Parameter id="ua4JjIjcHkeM73BSQk46Wg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                              <Parameter id="JtdOUNgHzUuJx9Nq1cOJGw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="5D8ZOzXK7EGOwj3jJsZ67w" visible="1" canBeVaried="1" displayUnit="l" />
-                              <Parameter id="jmp-aIjQiU-YOGYxZ4Sufw" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="mmPlMPjMnECVqmG5mkXJMw" visible="1" canBeVaried="1" />
-                              <MoleculeAmount id="EoUr17TiR061xnfZLxGy_A" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                                <Children>
-                                  <Parameter id="IVgD5nbUakKu8n9x7FLdFQ" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                                  <Parameter id="X2Zk5i1KLkakHfVDsYPsdw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="r0MwnWLJ1kuV_BTmDJhU3A" visible="0" canBeVaried="0" />
-                                  <Observer id="scf8b85HYUGSqmOsQ4QyMw" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
-                                </Children>
-                              </MoleculeAmount>
-                            </Children>
-                          </Container>
-                          <Container id="dEAYEXl0dk2Rv-tt0gU9NA" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                            <Tags>
-                              <Tag value="ColonSigmoid" />
-                              <Tag value="IntestinalSecretionSource" />
-                              <Tag value="LargeIntestineSegment" />
-                              <Tag value="Mucosa" />
-                            </Tags>
-                            <Children>
-                              <Parameter id="pNQs3kgyQEqY641RvEn59Q" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="dE28EI6hVk23fUjk1luoMw" visible="0" canBeVaried="0" displayUnit="l" />
-                              <Parameter id="2u3An4R1vEGXqeUHYZab2g" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="m5gWJCaKR0mYkdrFJN9OsQ" visible="1" canBeVaried="1" displayUnit="l" />
-                              <Parameter id="sYah6r3t7UuwgVMzB6nHRg" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.3" />
-                              <MoleculeAmount id="_FYwdcJVXUmHAbB3mDuZPw" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                                <Children>
-                                  <Parameter id="RhVa77MVsUuBgruXkwk94Q" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                                  <Parameter id="TxwzzKB2SEKbF7A9E3_vxA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="i-svm7btNki1MmZSx7aPCQ" visible="0" canBeVaried="0" />
-                                  <Observer id="nmDsQeq_pk6jwvoM1q61pg" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
-                                </Children>
-                              </MoleculeAmount>
-                            </Children>
-                          </Container>
-                        </Children>
-                      </Container>
-                      <Container id="eTVDE_oMIU2FA7eBEzy5rA" name="Rectum" description="Rectum" icon="Rectum" mode="Logical" containerType="Compartment">
-                        <Children>
-                          <Parameter id="XShI2O5E80WZzizmlSWgyw" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="uSjt8LuoBUu75Z4-7ZUOCw" visible="0" canBeVaried="1" displayUnit="kg" />
-                          <Parameter id="B3USVGiGB0KW7nibk2-GXQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="XYOKHZZUBkuhmruMPUCfwQ" visible="1" canBeVaried="1" displayUnit="l" />
-                          <Parameter id="sUN--K0BEk-hJpvvlLV8hg" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="et1rku1VQkqZCxraRd0LsA" visible="1" canBeVaried="1" displayUnit="l/min" />
-                          <Parameter id="N_L453vK-kqqSEYg7ID4CQ" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="uAObWhqnuUWsf3Ha6Zakyw" visible="1" canBeVaried="0" displayUnit="l" />
-                          <Parameter id="R0lS2QH0c0aWkPQzdzG8ig" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="NxoV47Ql00aifPKqk7nOJw" visible="1" canBeVaried="1" displayUnit="l/min" />
-                          <Parameter id="OPDqbUgWX0ebP4dOOQznCg" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="cDO00dCgEUa1Rf_VnhA32g" visible="1" canBeVaried="1" displayUnit="l/min" />
-                          <Parameter id="vguyG-M0nkWk6XI89ow0dA" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="LSHvGCmOBEascdPo-Ab-KQ" visible="1" canBeVaried="1" />
-                          <Parameter id="xZ-A7gK-FUKkTseRw9O9ag" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                          <Parameter id="JnRxdj5Tbkq4HZ25Fu-Wjw" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                          <Parameter id="zvqvTwnRNUKLQJbv3AXyJA" name="Fraction of regional blood flow rate" description="Regional blood flow fraction supplying the mucosal tissue of the segment" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.055" />
-                          <Parameter id="sceLS3xZIUu5ktsso4Bj3A" name="Fraction mucosa" description="Mucosal fraction of regional intestinal tissue mass" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.3" />
-                          <Parameter id="afJAtJk5TkKkWV8EX5EfJg" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="4.5E-08" displayUnit="µm" />
-                          <Parameter id="YjzJjH77P0KOFgUJmKLaFA" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.05" />
-                          <Parameter id="zMhy5Y-9oE6_4g4z3sN0tQ" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" visible="1" canBeVaried="1" value="1.86944444444444E-10" displayUnit="ml/min/N" />
-                          <Parameter id="CxLSEMW7VE2VNaSEWIV_mQ" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="2.5E-07" displayUnit="µm" />
-                          <Parameter id="Wv_UVX7xnU2hcIEToZRNyQ" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.06" />
-                          <Parameter id="KDibI6QkG0iCFznPAMuFxg" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0487" />
-                          <Parameter id="8pkgVWRTm0qnaO0OopejIQ" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.08" />
-                          <Parameter id="sjycTN2IKE2w_qyuO8hP6A" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.08" />
-                          <Parameter id="Qaf-DiEop0uDCfW05z4dFg" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0163" />
-                          <Parameter id="MCDdk8jRck6oFn1gNCVfLw" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.718" />
-                          <Parameter id="EIv1yIgkNkmRnZYl9V_agQ" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.8" />
-                          <Parameter id="td0J_8Byb02nIgTEiEQEyQ" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.158" />
-                          <Parameter id="sM-1i1yGFEeXc5HwnFm_gw" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-                          <Parameter id="bEuZwoxg40KO47fPHL3qeQ" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.141" />
-                          <Parameter id="cjRuStDOh0-eW3PMrTE8lg" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.69" />
-                          <Parameter id="6wsInkEwAkW74s29GZt8nA" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0483" />
-                          <Parameter id="cM45tElAZ06dC1IIs_mHnA" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0375" />
-                          <Parameter id="gatsTldYwEu2hQuIYEupzA" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0182" />
-                          <Parameter id="EmLf0OMyfUOU_AJRgmr1Ig" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0124" />
-                          <Parameter id="BllRYb5xkUurqYD8AFtyzw" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.282" />
-                          <Parameter id="jnZ_1V1BSUShwbxv8MyMGw" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.15" />
-                          <Parameter id="9jbvQoZdGk-lCiwqrP__Ig" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.456" />
-                          <Parameter id="Y51Wj2bYn0iscEGNSMSQ1w" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.78" />
-                          <Parameter id="BiAsJ5R23E-WXND0SDAVWQ" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0035" />
-                          <Parameter id="milO74DoIEe_5Ny1SKJvfg" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="2.41" />
-                          <Container id="WMIBikKwrEe1vMFMiv-ong" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                            <Tags>
-                              <Tag value="LargeIntestineSegment" />
-                              <Tag value="Mucosa" />
-                              <Tag value="Rectum" />
-                            </Tags>
-                            <Children>
-                              <Parameter id="v-jahAxSgU2r_ac6AMWMFg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                              <Parameter id="RAf2cNoro02VA1h3kXKm_g" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="AWSLB9BqIUm588s01h4uMw" visible="1" canBeVaried="1" displayUnit="l" />
-                              <MoleculeAmount id="w16XRTEu1kCkEKI9PKRZEg" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                                <Children>
-                                  <Parameter id="pPhh-Rz6W0Wnp7eT-judUg" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                                  <Parameter id="xCKVc5ZORku-Jttb3gteXA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="XUfzHl2FQ0yNUxOuYS5ubA" visible="0" canBeVaried="0" />
-                                  <Observer id="qgirPOhzF0iPtlfARw0xYw" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
-                                </Children>
-                              </MoleculeAmount>
-                            </Children>
-                          </Container>
-                          <Container id="XuC4VFLrok2cYGGvu6Zk6A" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                            <Tags>
-                              <Tag value="LargeIntestineSegment" />
-                              <Tag value="Mucosa" />
-                              <Tag value="Rectum" />
-                            </Tags>
-                            <Children>
-                              <Parameter id="hOuJfTQsW0iPwShj249F_g" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                              <Parameter id="zQ8VhEpfw0-tfL0h_gQnEw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="bFSKBq9P6ESwCQ7kJZpF0A" visible="1" canBeVaried="1" displayUnit="l" />
-                              <MoleculeAmount id="r0gwYEI_O0mcxiowmhPpKQ" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                                <Children>
-                                  <Parameter id="nXB1jHcvSk-70kISkg2Dog" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                                  <Parameter id="Zo2MkO1g-EmynnVdDQFiLw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="XYWLxGquMkON44W_eEYKiQ" visible="0" canBeVaried="0" />
-                                  <Observer id="yFz_NyBc30qoQWsMYYNrSQ" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
-                                </Children>
-                              </MoleculeAmount>
-                            </Children>
-                          </Container>
-                          <Container id="k2lXslAcv0O9A3Owj-loLg" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                            <Tags>
-                              <Tag value="LargeIntestineSegment" />
-                              <Tag value="Mucosa" />
-                              <Tag value="Rectum" />
-                            </Tags>
-                            <Children>
-                              <Parameter id="gwYDerA-s0WvcrAFjSAX4g" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                              <Parameter id="RFSgjGLtw022h8N3pka71g" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="5D8ZOzXK7EGOwj3jJsZ67w" visible="1" canBeVaried="1" displayUnit="l" />
-                              <Parameter id="kWsGpNMQR06kXR-k-qWhyQ" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="mmPlMPjMnECVqmG5mkXJMw" visible="1" canBeVaried="1" />
-                              <MoleculeAmount id="znbTFUnnCk6LEJuB7ZDqlg" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                                <Children>
-                                  <Parameter id="O08PkeohuUi_xwkUiaMUOA" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                                  <Parameter id="xvbMSJAkIUO33VH_BOXNww" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DToG4VhDpUac-5LHWuZ90A" visible="0" canBeVaried="0" />
-                                  <Observer id="U288iZ1DJUuhgBVhd_G7cQ" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
-                                </Children>
-                              </MoleculeAmount>
-                            </Children>
-                          </Container>
-                          <Container id="xqyjpic_fU-nSEKNKkYMGw" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                            <Tags>
-                              <Tag value="IntestinalSecretionSource" />
-                              <Tag value="LargeIntestineSegment" />
-                              <Tag value="Mucosa" />
-                              <Tag value="Rectum" />
-                            </Tags>
-                            <Children>
-                              <Parameter id="UjYDCk13c0ySi2qcfHbMHw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="dE28EI6hVk23fUjk1luoMw" visible="0" canBeVaried="0" displayUnit="l" />
-                              <Parameter id="19keXGvRgkGkbZDgVLlA9g" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="m5gWJCaKR0mYkdrFJN9OsQ" visible="1" canBeVaried="1" displayUnit="l" />
-                              <Parameter id="ARQHHUdzckSHDtLC5pZWTw" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.3" />
-                              <MoleculeAmount id="QVE4GWVZMEmvb2TwJk78sQ" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                                <Children>
-                                  <Parameter id="oH5dMUCAPESvP7iYGeQQCQ" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                                  <Parameter id="WUtODzeQgk25JtBektklWQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="xS7xdiryrESB-6DHK6IuAg" visible="0" canBeVaried="0" />
-                                  <Observer id="FWqN-8eGvUuRYOQiDoiQhQ" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
-                                </Children>
-                              </MoleculeAmount>
-                            </Children>
-                          </Container>
-                        </Children>
-                      </Container>
-                    </Children>
-                  </Container>
-                  <Container id="0R3AH4eoIUGff0VJeZFePw" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Observer id="xKiCLwVwmEaiF-3LV46WAQ" name="Interstitial Unbound" description="Interstitial Unbound" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="ZyvJ8fAke0mbYrfSrxcACw" displayUnit="µmol/l" />
-                      <Observer id="Jb6fJ4SkDkWuA9jwEbzmKQ" name="Intracellular Unbound" description="Intracellular Unbound" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="lHCXjnyQt0Wf_kfsvc1dyw" displayUnit="µmol/l" />
-                      <Observer id="7w2St-54S0a9MBz40FNxig" name="Total Tissue (Large Intestine)" description="Mucosa and nonmucosa tissue" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="qfVgYXFhbEucduXYqIuWzw" displayUnit="µmol/l" />
-                    </Children>
-                  </Container>
-                </Children>
-              </Container>
-              <Container id="Rhac5tMzcE25KAdsWPtHGw" name="Liver" description="Liver" icon="Liver" mode="Logical" containerType="Organ">
-                <Tags>
-                  <Tag value="TissueOrgan" />
-                </Tags>
-                <Children>
-                  <Parameter id="NrOpRdlSHEGKuOVrkGJYgQ" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="uSjt8LuoBUu75Z4-7ZUOCw" visible="0" canBeVaried="1" displayUnit="kg" />
-                  <Parameter id="AtgqOfsbC0O-6FFL0drZvQ" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="r6hKppO2VkWuS83bzmF1BQ" visible="1" canBeVaried="0" displayUnit="l" />
-                  <Parameter id="Tnw5zfmzRE2Ylj2IsCi8lA" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="W3YX7B87ekidvBNq8dvYuQ" visible="1" canBeVaried="1" displayUnit="l/min" />
-                  <Parameter id="aQEFNGVtfEuhNNiM6x5RvQ" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="bGAhSqB3sUmuhjRs59CY7Q" visible="1" canBeVaried="1" displayUnit="l/min" />
-                  <Parameter id="qQkDa14WM0i2wMFmqaGS3A" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="LSHvGCmOBEascdPo-Ab-KQ" visible="1" canBeVaried="1" />
-                  <Parameter id="OF5tAnY4Hk20L-iVfO7XQA" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="jdhhCNoMYE-s118HG9XzZw" visible="1" canBeVaried="1" displayUnit="l/min" />
-                  <Parameter id="2mipRXFbCkCXGhbDI66xYA" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                  <Parameter id="2CVYOFMM-ESxk8ng5Sdttg" name="EHC continuous fraction" description="Fraction of biliary secreted compound continuously entering the duodenum without being temporarily stored in the gallbladder. The fraction of hepatic bile directly entering the duodenum is species-dependent and amounts to about 30-50% in fasted humans to 100% in rats, because the rat lacks a gallbladder." persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" visible="1" canBeVaried="1" value="0" />
-                  <Parameter id="-1v0ZuDr2EmI99fr1j0rDA" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.75" />
-                  <Parameter id="Hbp5jRaXMU-NkUipQU6AkQ" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                  <Parameter id="RLOt45oegkK9fER77gzqKA" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" visible="1" canBeVaried="1" value="3.88888888888889E-11" displayUnit="ml/min/N" />
-                  <Parameter id="2uWbuWdISUK1_flVO-20Nw" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="3.3E-07" displayUnit="µm" />
-                  <Parameter id="ZJEkCmjtfU-Zy-0eSXpa0g" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="9E-08" displayUnit="µm" />
-                  <Parameter id="o9KzVTZPu0m2eQRiWV_NEQ" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.8" />
-                  <Parameter id="O9ToKIJLxUqoiXHT_guxkA" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.069" />
-                  <Parameter id="E8JifNC-C0uH0E1fQT49Ww" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0348" />
-                  <Parameter id="KBu4z6S9_Eq1a76ECxDhmQ" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.17" />
-                  <Parameter id="cV0uVcjZr0ar0XuK_HFo4g" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0252" />
-                  <Parameter id="2-iwnCE6U0SV7yU8EZFSMA" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.184" />
-                  <Parameter id="NXda-WPDRUSIzA_L_yJ5Ag" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.086" />
-                  <Parameter id="U2Be6gm090CyoWn9rc6pNA" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-                  <Parameter id="4mu-HNRgUE2OVZi-_o0lPg" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.161" />
-                  <Parameter id="HiM41q2VV0qpD7_uwGIi6Q" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.751" />
-                  <Parameter id="kV8rG9p_PEyJ6K-x5T8egA" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.747" />
-                  <Parameter id="knaEUHJ9H0SwtQYzT_F56A" name="Number of cells/g tissue" description="Number of cells per gram tissue" persistable="0" isFixedValue="0" dim="Count per mass" quantityType="Parameter" visible="0" canBeVaried="1" value="139000" displayUnit="x10^6/g" />
-                  <Parameter id="S4xV0Mikf02qW-aK3pgiUA" name="Microsomal protein mass/g tissue" description="Microsomal protein content per gram tissue" persistable="0" isFixedValue="0" dim="Mass per tissue" quantityType="Parameter" visible="0" canBeVaried="1" value="0.04" displayUnit="mg/g" />
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-                <Tags>
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-                  <Tag value="TissueOrgan" />
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-                      <Parameter id="NjqsAMbtRUq_dUJf8N7BpQ" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="Y5i-HZk9NUeoA7UKGgQIDg" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                      <Parameter id="4oBi_NHdC0-cLTeB-5qmag" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="hKXq5MVtGkCKHD0_pgT1Kg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                      <Parameter id="jKTZ42qhLka8_mgC6s1uOA" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="p_bsa76dkkG6bsceP87FTg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                      <Parameter id="GB_QYHB21kuEXti4ZzFF7Q" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                      <Parameter id="dV0y_4yQq0SX-gAUcx0ANA" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                      <Parameter id="pJ54alklUEmpQu8wB2nGZQ" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="R_GCvNJjkEOK7WViVxWftw" visible="0" canBeVaried="0" />
-                      <Transport id="h-xm2YBifEqFQzntG8aO0w" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Transport" dimension="Amount per time" formula="RGyVpQIBIUujbx5PLyJB4w" sourceAmount="JVBHLpp8bk-YmTIxkEKXPQ" targetAmount="j-CyXHPZe0Wv2zpXdSqmOg" />
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-                  <Parameter id="mMRgKleiZUCKZ2DJ5fK6XQ" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="zTjawHviokCp6BWrb8up4Q" visible="1" canBeVaried="1" displayUnit="cm²" />
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-                <Tags>
-                  <Tag value="Neighborhood: Plasma / BloodCells" />
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-                  <Container id="G7-Y2PNEykSD5bQ2hPWFmg" name="C1" mode="Logical" containerType="Molecule">
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-                      <Transport id="52aSObxb7EChzB2MUUIH3w" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="eOlA6dCqh0uwRhSs7h2i2Q" sourceAmount="rOGC7KehEkmFXF9mQPDiZQ" targetAmount="qMH9c4X4Ek6ugLGK4dEEug" />
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-                  <Parameter id="7i-oRY-UrUireZuvzELuxw" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="q2SZupdPBk29DbFWD_wiYA" visible="1" canBeVaried="1" displayUnit="cm²" />
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-                <Tags>
-                  <Tag value="Neighborhood: Interstitial / Intracellular" />
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-                <Children>
-                  <Container id="PkG9K5urvkiMrBbEtELCaQ" name="C1" mode="Logical" containerType="Molecule">
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-                      <Parameter id="lSw9V9j5rEeehJeJCnbDtQ" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="BtYHf38KbE2Woag0S8zVQw" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                      <Parameter id="Pl44GUMR30aZejlrudYCfQ" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="hKXq5MVtGkCKHD0_pgT1Kg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                      <Parameter id="8GCTrVIC7UObX-8zGH-PNQ" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="p_bsa76dkkG6bsceP87FTg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                      <Parameter id="t4dlGnqiIE2ihQHUjXpr-A" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                      <Parameter id="2gTKC61cUU2MhkC76i3PFw" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                      <Parameter id="_yfFL3kpzkeyfX2-EV7MZA" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="RHJFkoUWKUO_c5qodk8rdw" visible="1" canBeVaried="1" />
-                      <Parameter id="YJVxlJzXDU6PUvLRMTreLw" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="X8aa6JXQB0-b6a-LH5_Krw" visible="0" canBeVaried="1" />
-                      <Parameter id="nm3M5VxoTU2vpGs8cdWbTw" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="6G8Gj3AgAEq5Jo3c2a8Svg" visible="0" canBeVaried="0" />
-                      <Transport id="DY5x2buhcUqYh2VGgEGZmQ" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Transport" dimension="Amount per time" formula="o6QxkCBmRkqFi3GmZdSyYw" sourceAmount="LZKzN82i0E6J4Q0wAWWjGQ" targetAmount="9PKbTeAyNke-NAorSLhxfg" />
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-                  <Parameter id="khVDss3k-0u3RmtQ0zrcWQ" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="BaV3JwM-4U-Jb2MKQXaY_g" visible="1" canBeVaried="1" displayUnit="cm²" />
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-                <Tags>
-                  <Tag value="Neighborhood: Plasma / Plasma" />
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-                <Children>
-                  <Container id="-g5jGcb_fU-cWzwavC_lLg" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Transport id="4i7XUK4ICkyTYI1EyVxd9w" name="MassTransferOrgPl2BloodPool" description="Mass transfer from organ: Plasma to Venous Blood: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="06YOub9nGkOqMJ6QI0nikw" sourceAmount="rOGC7KehEkmFXF9mQPDiZQ" targetAmount="B3lPdr5IY0uIYf2oKyowmg" />
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-                <Tags>
-                  <Tag value="Neighborhood: Plasma / Interstitial" />
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-                <Children>
-                  <Container id="n5G2u5mtd0yd6D4-VMyqJw" name="C1" mode="Logical" containerType="Molecule">
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-                      <Parameter id="mE2oi7Oxh0a4hQKRkGXQWg" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="PXcfe353tkKGkqlyd4DxqA" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                      <Parameter id="j9ruZ49bJ0eLqpMDcTw1IQ" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Bon9EHArSU6bcCi8KdWj7w" visible="1" canBeVaried="1" />
-                      <Transport id="mMEOWyCMP0e3mRmIiWcVOg" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Transport" dimension="Amount per time" formula="LOE07hp0cEaAXnDa2IBZCg" sourceAmount="rOGC7KehEkmFXF9mQPDiZQ" targetAmount="LZKzN82i0E6J4Q0wAWWjGQ" />
-                    </Children>
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-                  <Parameter id="VB1Tk_MWuEiXPorRpVVDMw" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="ooNVHJv3WUKM0nfglnrDuw" visible="1" canBeVaried="1" displayUnit="cm²" />
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-                  <Tag value="Neighborhood: BloodCells / BloodCells" />
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-                  <Container id="mhW8ejSv5UWB1JCIQrDHsA" name="C1" mode="Logical" containerType="Molecule">
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-                      <Transport id="KzezxYkgx0a3AyaclqA7cQ" name="MassTransferOrgRBC2BloodPool" description="Mass transfer from organ: Blood Cells to Arterial Blood: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="G-SAJ5lGNUCBhFJmUIb4Jg" sourceAmount="qMH9c4X4Ek6ugLGK4dEEug" targetAmount="GWJuEfO1Xkqh3wAfzsLyqQ" />
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-              <Neighborhood id="76b4AEKV0kCgD0XWxp8bcg" name="Fat_pls_VenousBlood_pls" description="Neighborhood between Fat/Plasma and Venous Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="l3cprPldy0-s1EHY_moWpQ" secondNeighbor="J2AzZMiPQUibGWyUqz4XLA">
-                <Tags>
-                  <Tag value="Neighborhood: Plasma / Plasma" />
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-                <Children>
-                  <Container id="N8aYLJG5_0SYtwL1o_Yyug" name="C1" mode="Logical" containerType="Molecule">
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-                      <Transport id="lgEQwShRaE-EBbQ7opOsdQ" name="MassTransferOrgPl2BloodPool" description="Mass transfer from organ: Plasma to Venous Blood: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="MfpvLpacLEeQUO61eGcPLw" sourceAmount="oe9lGPCNGkOTlj2HvT3xWA" targetAmount="B3lPdr5IY0uIYf2oKyowmg" />
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-              <Neighborhood id="rVswRr6RUkivG1wZQySBMQ" name="Fat_pls_Fat_bc" description="Neighborhood between Fat/Plasma and Fat/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="l3cprPldy0-s1EHY_moWpQ" secondNeighbor="C6Aak1KuHE6WEnBWIms5EQ">
-                <Tags>
-                  <Tag value="Neighborhood: Plasma / BloodCells" />
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-                <Children>
-                  <Container id="gLh3Hf8OWkWx5FLJ7lEdyQ" name="C1" mode="Logical" containerType="Molecule">
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-                      <Transport id="mtkrubgrT0q3-UuTs8NAOw" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="5aLIGmTAvEq-0ti5pUcgrg" sourceAmount="oe9lGPCNGkOTlj2HvT3xWA" targetAmount="8YO8dduw-0WdLQKfJY0mOg" />
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-                  <Parameter id="5z-fdLCQ3E-zAzh78wbIDw" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="o8ujdUln4kO76TN-oPGOFw" visible="1" canBeVaried="1" displayUnit="cm²" />
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-                <Tags>
-                  <Tag value="Neighborhood: Interstitial / Intracellular" />
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-                <Children>
-                  <Container id="fcmaMPPcR0y6Lgl7VIvrqg" name="C1" mode="Logical" containerType="Molecule">
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-                      <Parameter id="EJAlu7ZXYE215B92tVQuZQ" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="Y5i-HZk9NUeoA7UKGgQIDg" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                      <Parameter id="bmw1TdrM7UehsXwxmUkbfg" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="hKXq5MVtGkCKHD0_pgT1Kg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                      <Parameter id="JgX33B-wjU6tzPQvpeH8zw" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="p_bsa76dkkG6bsceP87FTg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                      <Parameter id="K1S7APsmEkSzLLwd8Y3wFw" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                      <Parameter id="zwxSwGXA2EO0j4wmWJXLNA" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                      <Parameter id="WA2cLfGlxUi-GPeEsWbn8Q" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="X8aa6JXQB0-b6a-LH5_Krw" visible="0" canBeVaried="1" />
-                      <Parameter id="V7dQfFHBWk6G36Il1eqj4A" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="bkMaQzAXbkKZMfhu20C2dA" visible="1" canBeVaried="1" />
-                      <Parameter id="S7lAD_XgcE2ee-vbZ4wkwg" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="UvdVWmnPmk6Zrv_cuBjY9w" visible="0" canBeVaried="0" />
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-                <Tags>
-                  <Tag value="Neighborhood: BloodCells / BloodCells" />
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-                  <Container id="w9VOOYw_gUOnnUfyeqazBA" name="C1" mode="Logical" containerType="Molecule">
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-                      <Transport id="SiEa_C32d02MgkKDoUXexg" name="MassTransferOrgRBC2BloodPool" description="Mass transfer from organ: Blood Cells to Arterial Blood: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="j5y7xBG2ZUK8NtfyNW2h5A" sourceAmount="8YO8dduw-0WdLQKfJY0mOg" targetAmount="GWJuEfO1Xkqh3wAfzsLyqQ" />
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-                <Tags>
-                  <Tag value="Neighborhood: Plasma / Interstitial" />
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-                <Children>
-                  <Container id="4He7Bx_hgEyKRsLNhQInTg" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="671StCVPVka1RFwN1bUw4g" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" visible="1" canBeVaried="1" value="10" displayUnit="cm/min" />
-                      <Parameter id="gHZAPG8UR0Cb6h64OJJDjg" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Bon9EHArSU6bcCi8KdWj7w" visible="1" canBeVaried="1" />
-                      <Transport id="v52mJW6ne0SZ1CLCZqyBsQ" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Transport" dimension="Amount per time" formula="smrSXFIut0uS4zM5S43Clw" sourceAmount="oe9lGPCNGkOTlj2HvT3xWA" targetAmount="8bCP7EDFe0qGP2kTSb8qxQ" />
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-                  <Parameter id="BCePykvRikCS182idagqTQ" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="afSzcwVTEUSFqHscVKHrCQ" visible="1" canBeVaried="1" displayUnit="cm²" />
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-                <Tags>
-                  <Tag value="Neighborhood: BloodCells / BloodCells" />
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-                <Children>
-                  <Container id="h51shqN9p020lvRA_UkryQ" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Transport id="YhKSsOtY9U-NvMu-2cS79Q" name="MassTransferOrgRBC2BloodPool" description="Mass transfer from organ: Blood Cells to Arterial Blood: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="yXl9miUyXU-AWGDo1YDMdg" sourceAmount="NMsvr4OvokeBZq8LJ-XvXQ" targetAmount="GWJuEfO1Xkqh3wAfzsLyqQ" />
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-              <Neighborhood id="6LS0DlNX7kWC69EN_L7Y6A" name="Gonads_pls_VenousBlood_pls" description="Neighborhood between Gonads/Plasma and Venous Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="LjaheEHgMkKcij_K4QJW7g" secondNeighbor="J2AzZMiPQUibGWyUqz4XLA">
-                <Tags>
-                  <Tag value="Neighborhood: Plasma / Plasma" />
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-                <Children>
-                  <Container id="SKl0wJZegkeuwqz5rbHtBw" name="C1" mode="Logical" containerType="Molecule">
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-                      <Transport id="XGpt77GjOUiyUBP98eFCaw" name="MassTransferOrgPl2BloodPool" description="Mass transfer from organ: Plasma to Venous Blood: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="zR_kHpUco06Salsl9d1-dQ" sourceAmount="7v8TrBZxj028VHiqRTbv9A" targetAmount="B3lPdr5IY0uIYf2oKyowmg" />
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-                <Tags>
-                  <Tag value="Neighborhood: Plasma / Interstitial" />
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-                <Children>
-                  <Container id="xWPOzh2vX0KZsaiKD8FLog" name="C1" mode="Logical" containerType="Molecule">
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-                      <Parameter id="YEykFjsNgka6ayRABr-zhg" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" visible="1" canBeVaried="1" value="10" displayUnit="cm/min" />
-                      <Parameter id="zUpyZFBo_kmKqe7iWGdXGg" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Bon9EHArSU6bcCi8KdWj7w" visible="1" canBeVaried="1" />
-                      <Transport id="V_kxrdi1o0S6MTw-zg8VPA" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Transport" dimension="Amount per time" formula="iSVK--RYskWdfoHzdXPamQ" sourceAmount="7v8TrBZxj028VHiqRTbv9A" targetAmount="cLW8f3C6Akm9Gc4EaPRBCg" />
-                    </Children>
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-                  <Parameter id="nNSGK32xvEmTtnNACPWdiA" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="n5K8uWLFQEaPOHAzTn1thQ" visible="1" canBeVaried="1" displayUnit="cm²" />
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-              <Neighborhood id="8Jp8xvPkFUmOb_FtNNvvsQ" name="Gonads_pls_Gonads_bc" description="Neighborhood between Gonads/Plasma and Gonads/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="LjaheEHgMkKcij_K4QJW7g" secondNeighbor="4_tlbol5sEOUurLb-QmrqA">
-                <Tags>
-                  <Tag value="Neighborhood: Plasma / BloodCells" />
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-                <Children>
-                  <Container id="KukR0ADozkivNmSO7ZZq1g" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Transport id="Kp1J2sbhEU27Gfx9Qmt-tg" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="lfPLle5R9kOGbcQyd3yhrQ" sourceAmount="7v8TrBZxj028VHiqRTbv9A" targetAmount="NMsvr4OvokeBZq8LJ-XvXQ" />
-                    </Children>
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-                  <Parameter id="U9E3b1My00WNMnSGJf4xlw" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="XOsBORdt906NTQYSB-ajNg" visible="1" canBeVaried="1" displayUnit="cm²" />
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-                <Tags>
-                  <Tag value="Neighborhood: Interstitial / Intracellular" />
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-                <Children>
-                  <Container id="TbF2Cds2U0yL1UugFbI7Tg" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="dszkXr647UWwckJqm6VjTQ" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                      <Parameter id="KKBYMx7100emQxw2ofnIZw" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                      <Parameter id="51vVpb_suEW7qKOY5xPFhQ" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Kq38vAGPT0OwYrOZNLodkg" visible="1" canBeVaried="1" />
-                      <Parameter id="BkC_TQgjz0uSKLoTaLBEAw" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="X8aa6JXQB0-b6a-LH5_Krw" visible="0" canBeVaried="1" />
-                      <Parameter id="7WxgVeonLECc9Gr8M-QjUw" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="hKXq5MVtGkCKHD0_pgT1Kg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                      <Parameter id="N__7fpLEJ0eRXtaTfxQSyg" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="Y5i-HZk9NUeoA7UKGgQIDg" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                      <Parameter id="kpmuDa1xzUKBYbBxDOu2-w" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="p_bsa76dkkG6bsceP87FTg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                      <Parameter id="ZRvPYwhlJUmhDUqM59bJWA" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="BtYHf38KbE2Woag0S8zVQw" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                      <Parameter id="67ZiY0v91EOH2yaGlmkQjw" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="5VeZ5UY5vUq35ulK2FxZcQ" visible="0" canBeVaried="0" />
-                      <Transport id="YpXMbAsV_0GWlQucCpw3SQ" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Transport" dimension="Amount per time" formula="g2Iwo2sUVk-0UviKYrTt6A" sourceAmount="cLW8f3C6Akm9Gc4EaPRBCg" targetAmount="w376tfX_LEqdGN6dZkfsCw" />
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-                  <Parameter id="LNAoCIjrUkmG8pbL_ucesA" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="GMkcmIJge0-EQsV7a2yVFQ" visible="1" canBeVaried="1" displayUnit="cm²" />
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-                <Tags>
-                  <Tag value="Neighborhood: BloodCells / BloodCells" />
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-                <Children>
-                  <Container id="lPDoCpI8lkavXJc-PMRfUw" name="C1" mode="Logical" containerType="Molecule">
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-                      <Transport id="wc8VYjtm4kKNOfynXKYRAw" name="MassTransferOrgRBC2BloodPool" description="Mass transfer from organ: Blood Cells to Arterial Blood: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="qJ1gFzYRFkaM_xVYIY8ZPw" sourceAmount="Obwdz__ceEWQHALue4zdrw" targetAmount="GWJuEfO1Xkqh3wAfzsLyqQ" />
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-                <Tags>
-                  <Tag value="Neighborhood: Interstitial / Intracellular" />
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-                <Children>
-                  <Container id="2hAbG86bckWZrGPGbOcBwA" name="C1" mode="Logical" containerType="Molecule">
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-                      <Parameter id="bgCcQsOpZkOYjx8nxl-bAw" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="Y5i-HZk9NUeoA7UKGgQIDg" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                      <Parameter id="g55oKFCZv06DHKJ9W_TZdA" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="hKXq5MVtGkCKHD0_pgT1Kg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                      <Parameter id="GXaeEQNyhEW7tP7S3_cznQ" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="p_bsa76dkkG6bsceP87FTg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                      <Parameter id="lgQq340CEEGaeXztbLvJQA" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                      <Parameter id="ge258-7hZUCQKs20hrN1bA" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                      <Parameter id="eVjRFzhdpUOZykQoS8nDAw" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="28yZHpB_wEyTG5lWceWO8g" visible="1" canBeVaried="1" />
-                      <Parameter id="1C1ygFOzCE-4H25w_hnAYg" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="X8aa6JXQB0-b6a-LH5_Krw" visible="0" canBeVaried="1" />
-                      <Parameter id="lZiOtd1oUES5giWoToX8kQ" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="afu_TS7MBUyD6OoeTO4Jcg" visible="0" canBeVaried="0" />
-                      <Transport id="rW8oDaZP8Ei83EdQHkyYzg" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Transport" dimension="Amount per time" formula="X9IqIG_peESyHd7QCwEWHw" sourceAmount="aIf68iyeP0-G3GIM9GCG-g" targetAmount="rg9PTo0oHk6Ikb4dbfWN3g" />
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-                  <Parameter id="0a_Cmub6z0CMe7EEIvtJ1w" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="MFrxF-tdR0aLZJd_oDWD_w" visible="1" canBeVaried="1" displayUnit="cm²" />
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-                <Tags>
-                  <Tag value="Neighborhood: Plasma / BloodCells" />
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-                <Children>
-                  <Container id="ltOUl8jLXk2Iynk_9Y-Kxw" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
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-                  <Parameter id="yyy_nqI7iE6yvIIPPpEHEw" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="6ZB1BpA7wEK9xgaDzhEzLw" visible="1" canBeVaried="1" displayUnit="cm²" />
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-                <Tags>
-                  <Tag value="Neighborhood: Plasma / Interstitial" />
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-                <Children>
-                  <Container id="8QlR7KrQr0K5rOaGiAnplQ" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="iOBOu5-0PkGjKa4CGXldgQ" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" visible="1" canBeVaried="1" value="10" displayUnit="cm/min" />
-                      <Parameter id="yCLUAkQ2-k-mIqOXLQzsbA" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Bon9EHArSU6bcCi8KdWj7w" visible="1" canBeVaried="1" />
-                      <Transport id="GG_dZyfE40K96oXo23SBxg" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Transport" dimension="Amount per time" formula="zwFLIiTmsUOo9wr_jUmpkw" sourceAmount="qoaU-KhmBkSuINyqySeM2A" targetAmount="aIf68iyeP0-G3GIM9GCG-g" />
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-                  <Parameter id="pG59kOAcHkeSTiYvYCsCYw" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="RElvFiBLr02yPRZvyaQKNw" visible="1" canBeVaried="1" displayUnit="cm²" />
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-                <Tags>
-                  <Tag value="Neighborhood: Plasma / Plasma" />
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-                  <Container id="XalH85j7M0a2_9a2YeSWXw" name="C1" mode="Logical" containerType="Molecule">
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-                  <Tag value="Neighborhood: BloodCells / BloodCells" />
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-                  <Container id="Kb0jAIBz3EK-CDrKlURNIw" name="C1" mode="Logical" containerType="Molecule">
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-                      <Transport id="FIJXOz0Yz0CBVJ_O4QKVjw" name="MassTransferOrgRBC2BloodPool" description="Mass transfer from organ: Blood Cells to Arterial Blood: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="mt54uViaJEiXYrMsOLDjIA" sourceAmount="s0ARpvfc_kCXvSg1uyJo7w" targetAmount="GWJuEfO1Xkqh3wAfzsLyqQ" />
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-                  <Tag value="Neighborhood: Interstitial / Intracellular" />
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-                <Children>
-                  <Container id="IROdJLVpfkaGxxaF-hAnAw" name="C1" mode="Logical" containerType="Molecule">
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-                      <Parameter id="kfB4OwIEyk2VfE2_stdMtw" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="Y5i-HZk9NUeoA7UKGgQIDg" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                      <Parameter id="dlH8IyZyXE-t-8JsynT6zw" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="p_bsa76dkkG6bsceP87FTg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                      <Parameter id="tL3iShBRf0-roomYwCYA3g" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                      <Parameter id="YPwwschlvEKmc_UvZK49uA" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="avKhs_MMbECZxeGuujMtmg" visible="1" canBeVaried="1" />
-                      <Parameter id="aPRad8h8_UCwjYKDoeVJ7w" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="X8aa6JXQB0-b6a-LH5_Krw" visible="0" canBeVaried="1" />
-                      <Parameter id="P_nQUf1uLUKSQzLXBkmv7Q" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="hKXq5MVtGkCKHD0_pgT1Kg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                      <Parameter id="aFqfY7BNdUiexNCgqYSk6g" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="cPlEEKQG0kuLcnac-J1agA" visible="0" canBeVaried="0" />
-                      <Transport id="PKm2H7YCiUy5PAKOxOBC2g" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Transport" dimension="Amount per time" formula="YYBOHe_kj0maoyuSMNZa1A" sourceAmount="rLePgF_TyEiRY-5MFS7gYQ" targetAmount="awwqxHaZjk6cVuYVx6Qo6Q" />
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-                  <Parameter id="BcIPHsGU8EeQCETgT_8fcg" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="1YOQD4cfSU-pCHJvjIRkXA" visible="1" canBeVaried="1" displayUnit="cm²" />
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-                <Tags>
-                  <Tag value="Neighborhood: Intracellular / Urine" />
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-                <Children>
-                  <Container id="3CtVaZ-GEUKHQ1485UTjJQ" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="wYjmuFY640GA5lMwuzMgNA" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="VXEUQtjzoEuA_-UWXnE8rw" visible="0" canBeVaried="1" />
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-              <Neighborhood id="bUln7fDl30-xZMH24fr-hw" name="Kidney_pls_Kidney_bc" description="Neighborhood between Kidney/Plasma and Kidney/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="eUFCZIU4ekuNusmv0rogQA" secondNeighbor="fhpOPLdsBEC4DtZUc1zwcA">
-                <Tags>
-                  <Tag value="Neighborhood: Plasma / BloodCells" />
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-                <Children>
-                  <Container id="HI5P-eaYt0iVywRcZTfCEA" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Transport id="9CSyUPovuEq0_ugK9BL9Ig" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="IrMTD2KvL0OphA_NDecqJg" sourceAmount="E1GgL5W3o0mtgLyXCveGWQ" targetAmount="s0ARpvfc_kCXvSg1uyJo7w" />
-                    </Children>
-                  </Container>
-                  <Parameter id="Uf5OfL0oaUW0HfrViEFYHw" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="HrU4WdrJYkSJoZwAobB80A" visible="1" canBeVaried="1" displayUnit="cm²" />
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="kCji9qdFMUeQZqOjF3SL9w" name="Kidney_pls_Kidney_int" description="Neighborhood between Kidney/Plasma and Kidney/Interstitial" mode="Logical" containerType="Other" firstNeighbor="eUFCZIU4ekuNusmv0rogQA" secondNeighbor="qJpKdMNBEE66ash196CN-g">
-                <Tags>
-                  <Tag value="Neighborhood: Plasma / Interstitial" />
-                </Tags>
-                <Children>
-                  <Container id="93aUrfrvBUSxkpEPEF-xSw" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="9CO5eqcZ2UW9EpRL1TNiKw" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" visible="1" canBeVaried="1" value="10" displayUnit="cm/min" />
-                      <Parameter id="_eFU-yKXdEGBK8cY2lKn2w" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Bon9EHArSU6bcCi8KdWj7w" visible="1" canBeVaried="1" />
-                      <Transport id="nb4c0iNoVE2xkneJb9DGSw" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Transport" dimension="Amount per time" formula="OYtLt-SQLEOP3Q4dpYPF4w" sourceAmount="E1GgL5W3o0mtgLyXCveGWQ" targetAmount="rLePgF_TyEiRY-5MFS7gYQ" />
-                    </Children>
-                  </Container>
-                  <Parameter id="LgVCFL9IME2tGU03s_q_EA" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="DyMpBO0dlUGvZ139HnB02g" visible="1" canBeVaried="1" displayUnit="cm²" />
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="zSy5uf3EyEGdkEVkCPeknA" name="Kidney_pls_Kidney_ur" description="Neighborhood between Kidney/Plasma and Kidney/Urine" mode="Logical" containerType="Other" firstNeighbor="eUFCZIU4ekuNusmv0rogQA" secondNeighbor="s0wdzco21kO0XF6OWbSXow">
-                <Tags>
-                  <Tag value="Neighborhood: Plasma / Urine" />
-                </Tags>
-                <Children>
-                  <Container id="NzdHf2U29EK87F0pZ9KlDA" name="C1" mode="Logical" containerType="Molecule" />
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="ZLRyxzPZfEejT__x9ls0-Q" name="UpperJejunum_pls_PortalVein_pls" description="Neighborhood between Upper Jejunum/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="Mqff24qDg0q3J5knCoXTZw" secondNeighbor="-zX9e5Gif0qLF9-buV_xlA">
-                <Tags>
-                  <Tag value="Neighborhood: Plasma / Plasma" />
-                </Tags>
-                <Children>
-                  <Container id="1IkPf1j3kkaT19-K9c07-g" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="ukE3fj4-e0W_8LwvFL5Oqg" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="PKCiN5wizUqVY5mFTJrSAg" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Transport id="VFVxYri4_kG-6uFxygoAuw" name="MassTransferMucosaToPvePlasma" description="Mass transfer from Mucosa:Plasma To Portal Vein: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="X_ChVZC6jkCL-Jm44_dKXw" sourceAmount="PMNegnlhr0CXVnvfwhXU7g" targetAmount="hqBDuJ9j9Eqjy73I0KZSUA" />
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="yYtH-uUUgUSjrtyK-tzMWg" name="Lumen_uje_UpperJejunum_cell" description="Neighborhood between Lumen/Upper Jejunum and Mucosa/Upper Jejunum/Intracellular" mode="Logical" containerType="Other" firstNeighbor="CiHSzBkCCUudCrF-9qgurw" secondNeighbor="V6G7I9JiAUeouIcb-9qK3g">
-                <Tags>
-                  <Tag value="Neighborhood: UpperJejunum / Intracellular" />
-                </Tags>
-                <Children>
-                  <Container id="vI597wDO90ykKN3YnxXWGg" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="2cjwf94OhkOtSO41bvzb4A" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="Un4CTUv5OEqa_cWxTEk6Pw" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Parameter id="H1lzWD5ErUePht8BsU8uVA" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="A90y53VdVUerRM6490D5aw" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Parameter id="0Jnh6wMV2UWmTzIgNS-3QA" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="qr_x2cq_Y0C6Ur-VSCP4AQ" visible="0" canBeVaried="0" />
-                      <Parameter id="SGhUVxGBEEq9iGIiU754aQ" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="ezAHDPnckEKYf8L1jOtGfw" visible="0" canBeVaried="0" />
-                      <Parameter id="VpbIk98JGU2EW9rQL6p65w" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="Q_dCxqA6tUmASMG13Y4Ryw" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Parameter id="I1JzH53nxUqQBb8fsZmpPg" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="bOPO_JT8sEOF6PITZSGGVg" visible="0" canBeVaried="0" />
-                      <Parameter id="mRD0WqBDGkO-kBOKgDBJPg" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="aZYSS2yfyEqUEbGBDu38yg" visible="0" canBeVaried="0" />
-                      <Parameter id="Avndg_hHkk66Kn-WrFAt8g" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="2zimE-N2h0ajj62_0OpSxg" visible="0" canBeVaried="0" />
-                      <Parameter id="hecRxC7DUEGsDu7BKHEKpQ" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="6GPVjBLNFkKAA-LvCM11iQ" visible="0" canBeVaried="1" />
-                      <Parameter id="GNYugU7wWkObIlLVqF9Brw" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="TYANm0i6YUGgusd5XfO3Eg" visible="0" canBeVaried="0" />
-                      <Parameter id="wnu9LZN3NkOC9T9SyMS4-Q" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="HapbqTMKMUeiSlftTWOgog" visible="0" canBeVaried="0" />
-                      <Parameter id="3Pe1-AVGqEymSakYpfaGmw" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="QULpvKE_DkWTRmFwKaRm4g" visible="0" canBeVaried="0" />
-                      <Parameter id="safCSvOqAU2e8zpKpjAazg" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="0IIh6FJV0UKyrimES0f1xg" visible="0" canBeVaried="0" />
-                      <Parameter id="R2U8aIneUU-05D4KUNkaJA" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="KQgllSQtqk2EfhX37WilDQ" visible="0" canBeVaried="0" />
-                      <Parameter id="E5aJFwlD_EOvxdFBrhZNrg" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="aWekJ2NVAECIIbxJKJ8L5g" visible="0" canBeVaried="0" />
-                      <Parameter id="38b0nC5gp0KfTI9r6cPyng" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="3xvkxp6qK06bn4DgEtYULA" visible="0" canBeVaried="0" />
-                      <Parameter id="WN0J4XxA5UGvEfPmpIrj7A" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Iph7YhQ5KUmsZWUX2Xf2Wg" visible="0" canBeVaried="0" />
-                      <Parameter id="tPBHfD_9jk6SU2DyMEyD3w" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="2IVWcgM31UCSVl8zMDnDhw" visible="0" canBeVaried="0" />
-                      <Parameter id="IoUNpDVoAUSr5txUaev0vA" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DNGx_vFWp0KdOb7CGcoTLQ" visible="0" canBeVaried="0" />
-                      <Parameter id="-1n-xPlebka2Sjpn5pcMWw" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="LcUCvhU3W0udtbpS1KVhEQ" visible="0" canBeVaried="0" />
-                      <Parameter id="pLLeZiR6xk2aiTNiNwPVWA" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="FRFLar2u6UCfitupmR1dLw" visible="0" canBeVaried="0" />
-                      <Parameter id="hjf5DLFSc0CSf6_WkhfcKw" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="_83Rzqiye0Gy-hxsn6fgWQ" visible="0" canBeVaried="0" />
-                      <Parameter id="0Y4I4jMB902SacsZm6BV3Q" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="h2pHx5nvbUa67_2sS2-RkQ" visible="0" canBeVaried="0" />
-                      <Parameter id="JXkyBVdKcUKw3SvSRXLIfA" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="PEhoVdLppU-G3xULjX_71g" visible="0" canBeVaried="0" />
-                      <Parameter id="k45LAc9OhEOSpL5_qGMBIw" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="pGvG5UNdC0Sot3_d3Qdvag" visible="0" canBeVaried="0" />
-                      <Parameter id="TOSixYUwlEm8TRn78clmgg" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="jJfeJ2YxEki9TK9XP6uUMA" visible="0" canBeVaried="0" />
-                      <Parameter id="bDdqA3mXKE2hlvSbZLuHFg" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DNF0kWPUFk-rtSd0Ng1Mkw" visible="0" canBeVaried="0" />
-                      <Parameter id="GCOcn9QP8kGeXbBR8_V0OA" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="gxoZyuApjEuzsuLtZuZWmQ" visible="0" canBeVaried="0" />
-                      <Parameter id="LwEmxmxvOk-Y5BWyPMY8_Q" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="7NEiCDSKM0i6GhEpoWb-Mw" visible="0" canBeVaried="0" />
-                      <Transport id="NggnlRyKIU6XPU3GO1IzEg" name="DrugAbsorption_trans" description="Drug absorption transcellular" mode="Logical" containerType="Transport" dimension="Amount per time" formula="Tdt4nnPeT0-VOCfzEJMsbw" sourceAmount="V3v2rXqlRkujCVZ10rY3Ew" targetAmount="zqzRvmsGnUGFDX4cd4aGFQ">
-                        <Children>
-                          <Parameter id="fjeNAoL04UOdZukpGzR8rg" name="ProcessRate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="Tdt4nnPeT0-VOCfzEJMsbw" visible="0" canBeVaried="1" displayUnit="µmol/min">
-                            <Tags>
-                              <Tag value="DrugAbsorption_trans" />
-                              <Tag value="ProcessRate" />
-                              <Tag value="C1" />
-                              <Tag value="Lumen_uje_UpperJejunum_cell" />
-                              <Tag value="Passive" />
-                            </Tags>
-                          </Parameter>
-                        </Children>
-                      </Transport>
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="BLvKHvfCvkuhds4aeORxew" name="Lumen_uje_UpperJejunum_pls" description="Neighborhood between Lumen/Upper Jejunum and Mucosa/Upper Jejunum/Plasma" mode="Logical" containerType="Other" firstNeighbor="CiHSzBkCCUudCrF-9qgurw" secondNeighbor="Mqff24qDg0q3J5knCoXTZw">
-                <Tags>
-                  <Tag value="Neighborhood: UpperJejunum / Plasma" />
-                </Tags>
-                <Children>
-                  <Container id="6r47bpgG3k6LlQwgjGajsA" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="itPW0qPLME-o5cXpns3l6g" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="9iS9xCIJhESmNQVTrtJjPA" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Parameter id="D-aD6gpL8UKLResohZLo4A" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="REII40_qmUSHw_LndjzDZw" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Parameter id="3b5v95MNtE-sPVN6JG_2Tg" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="mjhQ-vpilkOE45QyIjxGrw" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Transport id="67Q_ZYz3kEG8E5HoM52vaQ" name="DrugAbsorption_para" description="Drug absorption paracellular" mode="Logical" containerType="Transport" dimension="Amount per time" formula="VkiYHcgVzES3s9uhrck6-g" sourceAmount="V3v2rXqlRkujCVZ10rY3Ew" targetAmount="PMNegnlhr0CXVnvfwhXU7g">
-                        <Children>
-                          <Parameter id="cbpMZKRJJUGmKYCl9ksCNQ" name="ProcessRate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="VkiYHcgVzES3s9uhrck6-g" visible="0" canBeVaried="1" displayUnit="µmol/min">
-                            <Tags>
-                              <Tag value="DrugAbsorption_para" />
-                              <Tag value="ProcessRate" />
-                              <Tag value="C1" />
-                              <Tag value="Lumen_uje_UpperJejunum_pls" />
-                              <Tag value="Passive" />
-                            </Tags>
-                          </Parameter>
-                        </Children>
-                      </Transport>
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="mRnd4O-vPU6HA-Fove8xpg" name="UpperJejunum_bc_PortalVein_bc" description="Neighborhood between Upper Jejunum/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="BiBid5i4Sk2EK94scFpeHw" secondNeighbor="V3IajphOTUWt3a2j9_LOZA">
-                <Tags>
-                  <Tag value="Neighborhood: BloodCells / BloodCells" />
-                </Tags>
-                <Children>
-                  <Container id="DvyGBmFybEidTZNMso0l7A" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="WONU0RmJTEqNWiUoi7wlkw" name="Mass transfer rate (mucosa to portal vein blood cells)" description="Mass transfer rate (mucosa to portal vein blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="iWxIyLeN6EOXrbiSubK04g" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Transport id="jytIB5yJEkKocie6n3yttQ" name="MassTransferMucosaToPveBC" description="Mass transfer from Mucosa:Blood Cells To Portal Vein: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="g_h_KvdyD0WW-bKowtXU9A" sourceAmount="RgAh2V1O4EKEVX6UAhe4zQ" targetAmount="3A4PxVITtUOpr85RBMQZlg" />
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="UotOSK9Jk06fxExR8_lvHA" name="Kidney_pls_VenousBlood_pls" description="Neighborhood between Kidney/Plasma and Venous Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="eUFCZIU4ekuNusmv0rogQA" secondNeighbor="J2AzZMiPQUibGWyUqz4XLA">
-                <Tags>
-                  <Tag value="Neighborhood: Plasma / Plasma" />
-                </Tags>
-                <Children>
-                  <Container id="Fvb0rbuJDUWEMXYUkcTO2Q" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Transport id="Kuti3D45KEGawKZYlfb68g" name="MassTransferOrgPl2BloodPool" description="Mass transfer from organ: Plasma to Venous Blood: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="716JyMTLCk2V_HA8FfYKNA" sourceAmount="E1GgL5W3o0mtgLyXCveGWQ" targetAmount="B3lPdr5IY0uIYf2oKyowmg" />
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="S_Y3q597TEyFvzQ4szqNkg" name="Lumen_uil_Lumen_lil" description="Neighborhood between Lumen/Upper Ileum and Lumen/Lower Ileum" mode="Logical" containerType="Other" firstNeighbor="Ybii6aaw1UeIsuUX1COdYA" secondNeighbor="igIrhkz7s0ehw7sHmKiBCg">
-                <Tags>
-                  <Tag value="Neighborhood: UpperIleum / LowerIleum" />
-                </Tags>
-                <Children>
-                  <Container id="S-WcdUPw8keDqV0yYe5O_w" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Transport id="F9MOA4xYQUGSOFlAbu9Ifw" name="LumenDrugTransport_lil" description="Lumen drug transport from Upper Ileum to Lower Ileum" mode="Logical" containerType="Transport" dimension="Amount per time" formula="6wS9svW1c0aBkzlA38kViA" sourceAmount="xrlOSQNSBk-WGtZ7E-tEYw" targetAmount="yw7rzbgJB0-l91_K8hz0sQ" />
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="TUmdlLHprEuyM5T6EUO10g" name="Lumen_sto_Lumen_duo" description="Neighborhood between Lumen/Stomach and Lumen/Duodenum" mode="Logical" containerType="Other" firstNeighbor="ioSVGmyZ-kaEQr2x4ccL0Q" secondNeighbor="RBDgGJ__rUCEJi-Z5h0eyg">
-                <Tags>
-                  <Tag value="Neighborhood: Stomach / Duodenum" />
-                </Tags>
-                <Children>
-                  <Container id="yYZl6KtwGk2qE8rIqdAWqA" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="oL9meknv5k2w__NiDl-KRw" name="Oral mass absorbed" description="Oral mass absorbed from Lumen into mucosa" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" formula="ubJru2ZxSkiyVRzC7EU9dw" visible="0" canBeVaried="0" displayUnit="µmol" />
-                      <Transport id="rVHwii0WiUCo4mPta9TUAw" name="LumenDrugTransport_duo" description="Lumen drug transport from Stomach to Duodenum" mode="Logical" containerType="Transport" dimension="Amount per time" formula="0HbRu9o2yEyST0m29X4mSQ" sourceAmount="r-aj2d-zBEqErgcKF5e5cw" targetAmount="BaeHcf6VhUyw3ftOPt1iIg" />
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="k8Oz_04UwEyiSHWxw1K7Mg" name="Lumen_duo_Lumen_uje" description="Neighborhood between Lumen/Duodenum and Lumen/Upper Jejunum" mode="Logical" containerType="Other" firstNeighbor="RBDgGJ__rUCEJi-Z5h0eyg" secondNeighbor="CiHSzBkCCUudCrF-9qgurw">
-                <Tags>
-                  <Tag value="Neighborhood: Duodenum / UpperJejunum" />
-                </Tags>
-                <Children>
-                  <Container id="ZOfrXN57q0uQQqFj5l6HAQ" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Transport id="KPvaFfmswUaB1suam4RpEA" name="LumenDrugTransport_uje" description="Lumen drug transport from Duodenum to Upper Jejunum" mode="Logical" containerType="Transport" dimension="Amount per time" formula="ffRcFOu61ka3rt87-1AqcA" sourceAmount="BaeHcf6VhUyw3ftOPt1iIg" targetAmount="V3v2rXqlRkujCVZ10rY3Ew" />
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="6IAQD43KoEmlVaFp5YKOUw" name="Lumen_lje_Lumen_uil" description="Neighborhood between Lumen/Lower Jejunum and Lumen/Upper Ileum" mode="Logical" containerType="Other" firstNeighbor="MLkuT5b_ikmcYGRo2SAH3w" secondNeighbor="Ybii6aaw1UeIsuUX1COdYA">
-                <Tags>
-                  <Tag value="Neighborhood: LowerJejunum / UpperIleum" />
-                </Tags>
-                <Children>
-                  <Container id="5xuLu5B3t0eiKNnt4g2l9Q" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Transport id="PIa39JHpn0uk9Mranan4ig" name="LumenDrugTransport_uil" description="Lumen drug transport from Lower Jejunum to Upper Ileum" mode="Logical" containerType="Transport" dimension="Amount per time" formula="nqTWtz3Uk0-wuaJ1jJ3YRQ" sourceAmount="Cuam5DbmZ0uqXwc9apFicg" targetAmount="xrlOSQNSBk-WGtZ7E-tEYw" />
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="XMMk_5hea06e4P2zciRwrQ" name="LowerJejunum_bc_PortalVein_bc" description="Neighborhood between Lower Jejunum/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="kDMQj4cgPkq4YoBI6vj_HA" secondNeighbor="V3IajphOTUWt3a2j9_LOZA">
-                <Tags>
-                  <Tag value="Neighborhood: BloodCells / BloodCells" />
-                </Tags>
-                <Children>
-                  <Container id="Ov6KEeyre0u5GnSScEyl7w" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="KyPQQn9VBU-Gtp2eR1Mpww" name="Mass transfer rate (mucosa to portal vein blood cells)" description="Mass transfer rate (mucosa to portal vein blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="-q6YmB7yWkexf1C7dzr2YQ" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Transport id="KOpDqDwzHkeJulJZjDyQWg" name="MassTransferMucosaToPveBC" description="Mass transfer from Mucosa:Blood Cells To Portal Vein: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="eu-y3O6a_Ui6vGmJfwW9Aw" sourceAmount="6Aqs6_wfI0OKiplexvNuNQ" targetAmount="3A4PxVITtUOpr85RBMQZlg" />
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="QqjGmc8Z2U6iuG5A3TusSA" name="Lumen_lil_Lumen_cae" description="Neighborhood between Lumen/Lower Ileum and Lumen/Cecum" mode="Logical" containerType="Other" firstNeighbor="igIrhkz7s0ehw7sHmKiBCg" secondNeighbor="jlQkJ9VHjEatlpKzMFmnlw">
-                <Tags>
-                  <Tag value="Neighborhood: LowerIleum / Caecum" />
-                </Tags>
-                <Children>
-                  <Container id="2_MkOShZAUenxuqpi9iEhw" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Transport id="KXK_cerR8kaxTAXPPBrnZg" name="LumenDrugTransport_cae" description="Lumen drug transport from Lower Ileum to Cecum" mode="Logical" containerType="Transport" dimension="Amount per time" formula="w6MTMOiAPkKvUPlJLjIo9Q" sourceAmount="yw7rzbgJB0-l91_K8hz0sQ" targetAmount="Qnj6YM6q_kSvSvGmWycE8g" />
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="rS1ii0EhNkC8_Oo2KKpsLg" name="Lumen_rect_Lumen_fec" description="Neighborhood between Lumen/Rectum and Lumen/Feces" mode="Logical" containerType="Other" firstNeighbor="eprwABQUEkOQApydkOYKug" secondNeighbor="IT6A3BRgbUSfIKDt5ltCRQ">
-                <Tags>
-                  <Tag value="Neighborhood: Rectum / Feces" />
-                </Tags>
-                <Children>
-                  <Container id="o_Iq4QUnCUOMjocF9_kt3Q" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Transport id="vG73VtohbUuK6x-6AUuETQ" name="LumenDrugTransport_fec" description="Lumen drug transport from Rectum to Feces" mode="Logical" containerType="Transport" dimension="Amount per time" formula="kw1UDji_uk6NiJHxcOPAEw" sourceAmount="2kdpKYdY3EeBvJPRNS1TEg" targetAmount="wdk5emL920WOkPCvQGJU-Q" />
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="kO70nkvEMkmYWtYiM9zZWA" name="Lumen_colasc_Lumen_coltrans" description="Neighborhood between Lumen/Colon Ascendens and Lumen/Colon Transversum" mode="Logical" containerType="Other" firstNeighbor="jhPiKsemqE2D9wuuFrqxsw" secondNeighbor="uB1rpzG6qkapR36UK4VYNQ">
-                <Tags>
-                  <Tag value="Neighborhood: ColonAscendens / ColonTransversum" />
-                </Tags>
-                <Children>
-                  <Container id="UYDuV0qVUE-U1K9tBa38KA" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Transport id="v5HlZri3UU2AhSWZp5WboA" name="LumenDrugTransport_coltrans" description="Lumen drug transport from Colon Ascendens to Colon Transversum" mode="Logical" containerType="Transport" dimension="Amount per time" formula="tPGnoB3RPEqahfqvz4OYPQ" sourceAmount="mgzsCzTwXkGLoEv-ZBAnNQ" targetAmount="B3i4ajvEPkWwF-QJhPT-RA" />
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="u7FcWPv9C0uHwtT-zRqWHw" name="Lumen_coltrans_Lumen_coldesc" description="Neighborhood between Lumen/Colon Transversum and Lumen/Colon Descendens" mode="Logical" containerType="Other" firstNeighbor="uB1rpzG6qkapR36UK4VYNQ" secondNeighbor="Tizt5eh3cUGAxWKaiYKVQw">
-                <Tags>
-                  <Tag value="Neighborhood: ColonTransversum / ColonDescendens" />
-                </Tags>
-                <Children>
-                  <Container id="foQHR26Dy0uXtJT9pcS2pA" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Transport id="nbXc7zccPUGvSPuNjXMAcQ" name="LumenDrugTransport_coldesc" description="Lumen drug transport from Colon Transversum to Colon Descendens" mode="Logical" containerType="Transport" dimension="Amount per time" formula="TCLqsm-Cak-IXlDWa0gWDQ" sourceAmount="B3i4ajvEPkWwF-QJhPT-RA" targetAmount="yiZ323gtz0WRt_37u8tDPQ" />
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="lk8YYuPjJ0i9M_Cyt3hPvA" name="Lumen_coldesc_Lumen_colsigm" description="Neighborhood between Lumen/Colon Descendens and Lumen/Colon Sigmoid" mode="Logical" containerType="Other" firstNeighbor="Tizt5eh3cUGAxWKaiYKVQw" secondNeighbor="FF0ppGi5GkaCMtFrfbD1kA">
-                <Tags>
-                  <Tag value="Neighborhood: ColonDescendens / ColonSigmoid" />
-                </Tags>
-                <Children>
-                  <Container id="t_qERdQ-y0yBS-XBxNmS5w" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Transport id="80pqDBu4mUmKJB6BvZDsWg" name="LumenDrugTransport_colsigm" description="Lumen drug transport from Colon Descendens to Colon Sigmoid" mode="Logical" containerType="Transport" dimension="Amount per time" formula="bvzHHTVaPEyzrIwkMAvPSA" sourceAmount="yiZ323gtz0WRt_37u8tDPQ" targetAmount="jIGCgtwn-U2Oqcv2W4G-ZQ" />
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="NhQ7z6j08USdZy3iOUJhnA" name="Lumen_colsigm_Lumen_rect" description="Neighborhood between Lumen/Colon Sigmoid and Lumen/Rectum" mode="Logical" containerType="Other" firstNeighbor="FF0ppGi5GkaCMtFrfbD1kA" secondNeighbor="eprwABQUEkOQApydkOYKug">
-                <Tags>
-                  <Tag value="Neighborhood: ColonSigmoid / Rectum" />
-                </Tags>
-                <Children>
-                  <Container id="g1zjNOCeVUGJgcfKYtEtHQ" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Transport id="ydJkuN3P9EGg4XaL7mEdeA" name="LumenDrugTransport_rect" description="Lumen drug transport from Colon Sigmoid to Rectum" mode="Logical" containerType="Transport" dimension="Amount per time" formula="SiOkN3wPk0O5sPFJsIhffw" sourceAmount="jIGCgtwn-U2Oqcv2W4G-ZQ" targetAmount="2kdpKYdY3EeBvJPRNS1TEg" />
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="fLWu6ptixUOv-qwPjJXxhw" name="Lumen_uje_Lumen_lje" description="Neighborhood between Lumen/Upper Jejunum and Lumen/Lower Jejunum" mode="Logical" containerType="Other" firstNeighbor="CiHSzBkCCUudCrF-9qgurw" secondNeighbor="MLkuT5b_ikmcYGRo2SAH3w">
-                <Tags>
-                  <Tag value="Neighborhood: UpperJejunum / LowerJejunum" />
-                </Tags>
-                <Children>
-                  <Container id="oa6OL4YXS0eB_BeMjb0HsA" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Transport id="DcHI_mixIUOBTzQ_ZJe9cA" name="LumenDrugTransport_lje" description="Lumen drug transport from Upper Jejunum to Lower Jejunum" mode="Logical" containerType="Transport" dimension="Amount per time" formula="Ao23g7a6G0eOkw5_gGkXNw" sourceAmount="V3v2rXqlRkujCVZ10rY3Ew" targetAmount="Cuam5DbmZ0uqXwc9apFicg" />
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="bvCWcfkxx0uFk2baVlklig" name="Lumen_cae_Lumen_colasc" description="Neighborhood between Lumen/Cecum and Lumen/Colon Ascendens" mode="Logical" containerType="Other" firstNeighbor="jlQkJ9VHjEatlpKzMFmnlw" secondNeighbor="jhPiKsemqE2D9wuuFrqxsw">
-                <Tags>
-                  <Tag value="Neighborhood: Caecum / ColonAscendens" />
-                </Tags>
-                <Children>
-                  <Container id="Hx8zrt-RKUWya51ujXF3MQ" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Transport id="3lUcpPTMG0aQMgc-XjQY4A" name="LumenDrugTransport_colasc" description="Lumen drug transport from Cecum to Colon Ascendens" mode="Logical" containerType="Transport" dimension="Amount per time" formula="HRuLTkmUJ0-J02Ale_W-RQ" sourceAmount="Qnj6YM6q_kSvSvGmWycE8g" targetAmount="mgzsCzTwXkGLoEv-ZBAnNQ" />
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="H5J1L_v1q0GXPKvQ18zg1Q" name="Lumen_lje_LowerJejunum_pls" description="Neighborhood between Lumen/Lower Jejunum and Mucosa/Lower Jejunum/Plasma" mode="Logical" containerType="Other" firstNeighbor="MLkuT5b_ikmcYGRo2SAH3w" secondNeighbor="qnwzbs7P1EuiOU6I1AbUmw">
-                <Tags>
-                  <Tag value="Neighborhood: LowerJejunum / Plasma" />
-                </Tags>
-                <Children>
-                  <Container id="qY_uIgswXECrqHLcIK8Gfg" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="gMtRaJkUM0iQFdCjLYKzwg" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="TtAJshznRkWVyDtwmvn2jA" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Parameter id="OQs0iUcZnkWbec3GuyVSGQ" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="qPm6Z-NEdkq2e73kCRbGTQ" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Parameter id="z3GHf_YYo0e65t019oq_mg" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="OKF58T-cY0GKbERZrkrlfA" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Transport id="7kUWrwpGN0STXLxUKxQJ-A" name="DrugAbsorption_para" description="Drug absorption paracellular" mode="Logical" containerType="Transport" dimension="Amount per time" formula="sq1EM757bkyF5h-PABNaKw" sourceAmount="Cuam5DbmZ0uqXwc9apFicg" targetAmount="YgLswliwdkSHukAAVZwL5w">
-                        <Children>
-                          <Parameter id="54OrWySO7UGcUXjfeLHKRg" name="ProcessRate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="mw50aqceKUi0aJwLiv-Aug" visible="0" canBeVaried="1" displayUnit="µmol/min">
-                            <Tags>
-                              <Tag value="DrugAbsorption_para" />
-                              <Tag value="ProcessRate" />
-                              <Tag value="C1" />
-                              <Tag value="Lumen_lje_LowerJejunum_pls" />
-                              <Tag value="Passive" />
-                            </Tags>
-                          </Parameter>
-                        </Children>
-                      </Transport>
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="c-Sg629JPE-5vpcJWLL2JA" name="Lumen_lje_LowerJejunum_cell" description="Neighborhood between Lumen/Lower Jejunum and Mucosa/Lower Jejunum/Intracellular" mode="Logical" containerType="Other" firstNeighbor="MLkuT5b_ikmcYGRo2SAH3w" secondNeighbor="ZS1XYMqua0eBDvqguAeY6g">
-                <Tags>
-                  <Tag value="Neighborhood: LowerJejunum / Intracellular" />
-                </Tags>
-                <Children>
-                  <Container id="OKlAFzjBkk6dRHcYce6R-g" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="eVHDYPTbn0Gxi0oR258x8A" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="e5VKR7JKZk21U9HJlD7A5A" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Parameter id="aRMqG8YiJUSfAJZmXrUjOw" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="ezAHDPnckEKYf8L1jOtGfw" visible="0" canBeVaried="0" />
-                      <Parameter id="HoF05HSnoECy6ma0fLW49A" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="bOPO_JT8sEOF6PITZSGGVg" visible="0" canBeVaried="0" />
-                      <Parameter id="kpZ2pWIAREOf26ajpN57Aw" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="aZYSS2yfyEqUEbGBDu38yg" visible="0" canBeVaried="0" />
-                      <Parameter id="KEjvu8K0bU-x5UhB6Rfh9w" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="UIZ0gcOFXUiFj9biQD1zow" visible="0" canBeVaried="0" />
-                      <Parameter id="8TkJgXR0t0OF6aOZRJhQNw" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="GGJAYlTgPkeZx_0cWJIgTg" visible="0" canBeVaried="1" />
-                      <Parameter id="pIi7IQPSjUCwE8mrzBGkCQ" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="-mXfGiMZ6kqYIipaBj_jtA" visible="0" canBeVaried="0" />
-                      <Parameter id="dP1dGtpJPkGPvUmMWmBcoA" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="6gxbxlaZrkGnoa2ICzyhkQ" visible="0" canBeVaried="0" />
-                      <Parameter id="bIa7u7dUbkaoHUfQYOdCLQ" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="lWjfwuEkmkC6QL_K4IgAEg" visible="0" canBeVaried="0" />
-                      <Parameter id="JVDs6Rue4k-93swPV0FsDg" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="0IIh6FJV0UKyrimES0f1xg" visible="0" canBeVaried="0" />
-                      <Parameter id="VjuOi3nsMEiCx07owtH--A" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="KQgllSQtqk2EfhX37WilDQ" visible="0" canBeVaried="0" />
-                      <Parameter id="tur2eyKyHE-EURd-OjBFWQ" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="7NEiCDSKM0i6GhEpoWb-Mw" visible="0" canBeVaried="0" />
-                      <Parameter id="rElBaUiIRk29ylzpW4ofsQ" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="2IVWcgM31UCSVl8zMDnDhw" visible="0" canBeVaried="0" />
-                      <Parameter id="wHq1JClhDUqX1OY_i5T9MA" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="3xvkxp6qK06bn4DgEtYULA" visible="0" canBeVaried="0" />
-                      <Parameter id="45pYIyCodEe9IwXvEM3L3Q" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="Zf9gIX4iaESROWARmz0HTw" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Parameter id="MX8mes-nkEqu-nL_PfPQJQ" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DNGx_vFWp0KdOb7CGcoTLQ" visible="0" canBeVaried="0" />
-                      <Parameter id="lhtmfttjJkmiX6VtT26acg" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="LcUCvhU3W0udtbpS1KVhEQ" visible="0" canBeVaried="0" />
-                      <Parameter id="iDQcEll9_0KfORluREPVlw" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="H3HPWZTpMkWd61SPEdQpWw" visible="0" canBeVaried="0" />
-                      <Parameter id="ZXM30LeWXEKaUnyd_8trwQ" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="VxA-igQ9skyfsGhm2IVqug" visible="0" canBeVaried="0" />
-                      <Parameter id="VODqInATG02sW74QZKz4bw" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="iYmEEK30bE-ZTPT-N_n7Jg" visible="0" canBeVaried="0" />
-                      <Parameter id="9_88d95ehEaQh719vO7kog" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="PEhoVdLppU-G3xULjX_71g" visible="0" canBeVaried="0" />
-                      <Parameter id="jzbFvK45D0Wm3dUQy1J6kQ" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="pGvG5UNdC0Sot3_d3Qdvag" visible="0" canBeVaried="0" />
-                      <Parameter id="iSuEgjn5DEOqqm8HjQcLbQ" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="jJfeJ2YxEki9TK9XP6uUMA" visible="0" canBeVaried="0" />
-                      <Parameter id="vr2OxzW1CE-XaMzhGUe_eA" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DNF0kWPUFk-rtSd0Ng1Mkw" visible="0" canBeVaried="0" />
-                      <Parameter id="FXy5x5JWkk-NYlPdchhDLw" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="gxoZyuApjEuzsuLtZuZWmQ" visible="0" canBeVaried="0" />
-                      <Parameter id="PAYJ2W5nLEe8wEM1iciwRw" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="qr_x2cq_Y0C6Ur-VSCP4AQ" visible="0" canBeVaried="0" />
-                      <Parameter id="jcqAWMfu1UWxa86q396A2w" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="aWekJ2NVAECIIbxJKJ8L5g" visible="0" canBeVaried="0" />
-                      <Parameter id="n9Vrr-qSF0e-eVGEL6FGdg" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="LG8vT-2Ek02sc2rShJ8d3g" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Parameter id="Xc-8is5P6Eygsnmw2DfvAg" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Iph7YhQ5KUmsZWUX2Xf2Wg" visible="0" canBeVaried="0" />
-                      <Transport id="U4Kk7jFwdECTnoA9usDopg" name="DrugAbsorption_trans" description="Drug absorption transcellular" mode="Logical" containerType="Transport" dimension="Amount per time" formula="NFRdEG5shk2d-mCeDgrlIg" sourceAmount="Cuam5DbmZ0uqXwc9apFicg" targetAmount="K8vctNgQvkyF2UEwPTSuVQ">
-                        <Children>
-                          <Parameter id="L3QoglqVcU65CM2XTrWKWA" name="ProcessRate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="3CsAk22RCEaxkrAQOfwt2w" visible="0" canBeVaried="1" displayUnit="µmol/min">
-                            <Tags>
-                              <Tag value="DrugAbsorption_trans" />
-                              <Tag value="ProcessRate" />
-                              <Tag value="C1" />
-                              <Tag value="Lumen_lje_LowerJejunum_cell" />
-                              <Tag value="Passive" />
-                            </Tags>
-                          </Parameter>
-                        </Children>
-                      </Transport>
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="clWES9ffs06A2QAZIT1JBQ" name="LowerJejunum_pls_PortalVein_pls" description="Neighborhood between Lower Jejunum/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="qnwzbs7P1EuiOU6I1AbUmw" secondNeighbor="-zX9e5Gif0qLF9-buV_xlA">
-                <Tags>
-                  <Tag value="Neighborhood: Plasma / Plasma" />
-                </Tags>
-                <Children>
-                  <Container id="ThZPi3HkT0O_AJ_y8tOESA" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="xi2hhyn4HkGouepHn70uUg" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="4_Nba8MJ-E6AHiiiBrNiEg" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Transport id="ScUg5k6WZUuDEJrAYe1nmA" name="MassTransferMucosaToPvePlasma" description="Mass transfer from Mucosa:Plasma To Portal Vein: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="-6RlIIuRRUeF_WulQ-kNFA" sourceAmount="YgLswliwdkSHukAAVZwL5w" targetAmount="hqBDuJ9j9Eqjy73I0KZSUA" />
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="I3rD-E4CsUCIKJOvJ7qYsg" name="UpperIleum_pls_PortalVein_pls" description="Neighborhood between Upper Ileum/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="wiKdxf5lkUaXODbbzJ_MgA" secondNeighbor="-zX9e5Gif0qLF9-buV_xlA">
-                <Tags>
-                  <Tag value="Neighborhood: Plasma / Plasma" />
-                </Tags>
-                <Children>
-                  <Container id="Q9VM4rwtck2NgkzvtRFA5w" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="hfEs2WmY6UOEMXxoMjxbjg" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="GyZRHXG4KEiJ95SiO3gCdw" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Transport id="RaJFTdwlskeL4ViWdNrtqA" name="MassTransferMucosaToPvePlasma" description="Mass transfer from Mucosa:Plasma To Portal Vein: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="WfFyZVWLQ0ewx6Hu6RWEuQ" sourceAmount="OH4tJOZD_USLmfI7ahxt3w" targetAmount="hqBDuJ9j9Eqjy73I0KZSUA" />
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="gwv0fANZQU6tWMZn6TFmCA" name="Stomach_pls_Stomach_bc" description="Neighborhood between Stomach/Plasma and Stomach/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="HZ6pfKhao0S84LcP_vvjSQ" secondNeighbor="J3KHzmzoG0ybBAX8Q-IY2w">
-                <Tags>
-                  <Tag value="Neighborhood: Plasma / BloodCells" />
-                </Tags>
-                <Children>
-                  <Container id="GeQgeX5esEuHCbzZjSJ5iA" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Transport id="AnGzWckUdEaSxB8vV6gG0Q" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="MjgW2pg88k2M_xJoKkYM9A" sourceAmount="bgD3avhorEm8i92Um2o6Mw" targetAmount="PyfLvFgK0EK6vo6Wn0xZ1g" />
-                    </Children>
-                  </Container>
-                  <Parameter id="Q_0VMriYd0OhIDUbjISrmg" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="V94T1ku3YE2zBCMsCHn-7g" visible="1" canBeVaried="1" displayUnit="cm²" />
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="ptvN1wCP1kmmue80CmwVEA" name="Stomach_pls_Stomach_int" description="Neighborhood between Stomach/Plasma and Stomach/Interstitial" mode="Logical" containerType="Other" firstNeighbor="HZ6pfKhao0S84LcP_vvjSQ" secondNeighbor="T6m82MqYTUWHudDqo8uO-w">
-                <Tags>
-                  <Tag value="Neighborhood: Plasma / Interstitial" />
-                </Tags>
-                <Children>
-                  <Container id="BO631daSYEaIMDtnDswd_Q" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="6RF8s7qdnUuSMDZv1v3Kzg" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Bon9EHArSU6bcCi8KdWj7w" visible="1" canBeVaried="1" />
-                      <Parameter id="-oFKL5R310-hUkkR_8GqCg" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" visible="1" canBeVaried="1" value="10" displayUnit="cm/min" />
-                      <Transport id="NXOds84JrEuNtmPeUeP1mg" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Transport" dimension="Amount per time" formula="t7sIkEpJyECiSxZH-5QVYQ" sourceAmount="bgD3avhorEm8i92Um2o6Mw" targetAmount="Isc12GChREuJ16lL5ZYXXA" />
-                    </Children>
-                  </Container>
-                  <Parameter id="6e2RUafQ-UyPNQKxZla5xw" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="rvFP9s4JMUmXZcnLgOglRg" visible="1" canBeVaried="1" displayUnit="cm²" />
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="4hFN6Qg7QUWtk6y6agClTA" name="Stomach_pls_PortalVein_pls" description="Neighborhood between Stomach/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="HZ6pfKhao0S84LcP_vvjSQ" secondNeighbor="-zX9e5Gif0qLF9-buV_xlA">
-                <Tags>
-                  <Tag value="Neighborhood: Plasma / Plasma" />
-                </Tags>
-                <Children>
-                  <Container id="ao4Wn1ZuOEu6FZwaP3i3iA" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Transport id="nwXNd2rkQUOTQnz_aBYNPw" name="MassTransferOrgPl2BloodPool_pve" description="Mass transfer from organ: Plasma to Portal Vein: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="xb0nS38VW0K0NGGS1IcAig" sourceAmount="bgD3avhorEm8i92Um2o6Mw" targetAmount="hqBDuJ9j9Eqjy73I0KZSUA" />
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="3M3r6gS3m0mUNlML5gkqAQ" name="Stomach_bc_PortalVein_bc" description="Neighborhood between Stomach/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="J3KHzmzoG0ybBAX8Q-IY2w" secondNeighbor="V3IajphOTUWt3a2j9_LOZA">
-                <Tags>
-                  <Tag value="Neighborhood: BloodCells / BloodCells" />
-                </Tags>
-                <Children>
-                  <Container id="1vOzfYXrp0qKbFULh9seIQ" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Transport id="xOXiH7yKUEut3rfs88KnjA" name="MassTransferOrgRBC2BloodPool_Pve" description="Mass transfer from organ: Blood Cells to Portal Vein: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="nUZetu67z0yzTCcYT3CHXQ" sourceAmount="PyfLvFgK0EK6vo6Wn0xZ1g" targetAmount="3A4PxVITtUOpr85RBMQZlg" />
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="qJc-4a_-vkasU7CSMxgIug" name="Stomach_int_Stomach_cell" description="Neighborhood between Stomach/Interstitial and Stomach/Intracellular" mode="Logical" containerType="Other" firstNeighbor="T6m82MqYTUWHudDqo8uO-w" secondNeighbor="AfhvD7y_NUClB-Olz_JKzA">
-                <Tags>
-                  <Tag value="Neighborhood: Interstitial / Intracellular" />
-                </Tags>
-                <Children>
-                  <Container id="n4pFo4g7RUWXQ-N5HOU-CQ" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="P6EeaJSLr0ieTu7L7JN9Tg" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="BtYHf38KbE2Woag0S8zVQw" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                      <Parameter id="2DxX3fqc6E2J5IiaHjWuWw" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="Y5i-HZk9NUeoA7UKGgQIDg" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                      <Parameter id="1vz2YRO4oEeSkjGMS2coEA" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="hKXq5MVtGkCKHD0_pgT1Kg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                      <Parameter id="e5M_dL6Qhkaf602n77TOgw" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="p_bsa76dkkG6bsceP87FTg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                      <Parameter id="6h46HmSSA0ycxMGDuLs_yw" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                      <Parameter id="Gpyntyc5qEK9R__Bb3mHZA" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                      <Parameter id="WrmUaDQ5_UO-YP0C9SJDTQ" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Extj3R_cA0GvjftmyoW9nQ" visible="1" canBeVaried="1" />
-                      <Parameter id="8N-FY7X6sUq2Fk6Gs2Y8Cw" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="X8aa6JXQB0-b6a-LH5_Krw" visible="0" canBeVaried="1" />
-                      <Parameter id="GL7kTm5Fok-gZkaeYHJ0XA" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Vh142ka7RUqyMKoJeL2S8A" visible="0" canBeVaried="0" />
-                      <Transport id="e_EvRTDgbEubwK5wwOPL4A" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Transport" dimension="Amount per time" formula="vCIADRpYg02CHjn42nPZzg" sourceAmount="Isc12GChREuJ16lL5ZYXXA" targetAmount="eyoS1wkcpUqkLrnsBNsX3A" />
-                    </Children>
-                  </Container>
-                  <Parameter id="fwD4gJ1M9Um9V1MfU9Ko2w" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="YhCvAsTu9U-JH6G0rIWy9A" visible="1" canBeVaried="1" displayUnit="cm²" />
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="MayYVJSu7kStiC9Hii2iDA" name="Lumen_uil_UpperIleum_cell" description="Neighborhood between Lumen/Upper Ileum and Mucosa/Upper Ileum/Intracellular" mode="Logical" containerType="Other" firstNeighbor="Ybii6aaw1UeIsuUX1COdYA" secondNeighbor="Mn_3bNMJfUilEEDCF8BgJg">
-                <Tags>
-                  <Tag value="Neighborhood: UpperIleum / Intracellular" />
-                </Tags>
-                <Children>
-                  <Container id="LHvhfzmjPEmFlftnVRfWSw" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="PKMMO6a4jEShp6qX-zv6ZA" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="_4sjUNECnUiBj5KmYH1gDQ" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Parameter id="d-d6HFjjEU6gGp-4HBJSig" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="uWbirbCcR0G61mvoJ385Ow" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Parameter id="Pk6gqMGJ5U6lLbKBypKXCw" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="LcUCvhU3W0udtbpS1KVhEQ" visible="0" canBeVaried="0" />
-                      <Parameter id="OP2qUa7LYUKhkd5WzEG9kw" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="aZYSS2yfyEqUEbGBDu38yg" visible="0" canBeVaried="0" />
-                      <Parameter id="7WMQoh36ckGKgpoRqm7iBw" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="OQh7fEoCEUuGah6Zm2hLIA" visible="0" canBeVaried="0" />
-                      <Parameter id="G5vb43G7NkS84rKNo_f-Aw" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CXCSte4ymkyb6-II7VT-3Q" visible="0" canBeVaried="1" />
-                      <Parameter id="L-TB_e7xB06fRlWDhjPdOQ" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="gwtmepUtvk-Pz1m8ha5jMw" visible="0" canBeVaried="0" />
-                      <Parameter id="1bOIk1kAOkOu5X6VQJ8gLw" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IaQYSZMsg0G1acTY5VDIiA" visible="0" canBeVaried="0" />
-                      <Parameter id="0YbRzt8KUEmEIxzX6b4CmA" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="-847g-sa6U2HMDOHFWqrew" visible="0" canBeVaried="0" />
-                      <Parameter id="ILVOE__urUW-HSvIt0Wq6g" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="0IIh6FJV0UKyrimES0f1xg" visible="0" canBeVaried="0" />
-                      <Parameter id="zTk0-FoyQUOqKsp04eBf-A" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="KQgllSQtqk2EfhX37WilDQ" visible="0" canBeVaried="0" />
-                      <Parameter id="GjDY-AJgxEK6AE-TKDGhsQ" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="7NEiCDSKM0i6GhEpoWb-Mw" visible="0" canBeVaried="0" />
-                      <Parameter id="Jm3Tg05_nUWjDgfzDaOm0g" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="3xvkxp6qK06bn4DgEtYULA" visible="0" canBeVaried="0" />
-                      <Parameter id="qk5cYbM9606u6Xw5LmEhyA" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="ezAHDPnckEKYf8L1jOtGfw" visible="0" canBeVaried="0" />
-                      <Parameter id="Qu2zIEo_TUCsFHfyXtmLQw" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DNGx_vFWp0KdOb7CGcoTLQ" visible="0" canBeVaried="0" />
-                      <Parameter id="T5FmW35ly0WIIQDekaNjfg" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="28kNOB9NjEushKneTf6Enw" visible="0" canBeVaried="0" />
-                      <Parameter id="RjskY4ua2UKPt9QSPzlQDQ" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="HMAKJZSsCU27DuQ7um9X2A" visible="0" canBeVaried="0" />
-                      <Parameter id="46MpA022A0GrluVuZOC9dg" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="4ncCXM1VXEuS8vjLrNtA3A" visible="0" canBeVaried="0" />
-                      <Parameter id="vM_6rhF_oUeWe8FnIzR14g" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="PEhoVdLppU-G3xULjX_71g" visible="0" canBeVaried="0" />
-                      <Parameter id="0O8fzjt23EqjQ2xrWKVadg" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="pGvG5UNdC0Sot3_d3Qdvag" visible="0" canBeVaried="0" />
-                      <Parameter id="Mub2jWno20e5ReDxJ8vaBQ" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="jJfeJ2YxEki9TK9XP6uUMA" visible="0" canBeVaried="0" />
-                      <Parameter id="IUdooqeQEkelGc1FLdO2kw" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DNF0kWPUFk-rtSd0Ng1Mkw" visible="0" canBeVaried="0" />
-                      <Parameter id="bEkW3OocLk-WleFA3_GtIg" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="gxoZyuApjEuzsuLtZuZWmQ" visible="0" canBeVaried="0" />
-                      <Parameter id="sSNKwgIIlkqaT7Hno9vNEg" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="qr_x2cq_Y0C6Ur-VSCP4AQ" visible="0" canBeVaried="0" />
-                      <Parameter id="R-2-FeSBr02KBSay52p_4Q" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Iph7YhQ5KUmsZWUX2Xf2Wg" visible="0" canBeVaried="0" />
-                      <Parameter id="iQ9HVhBUa0GthXTLQdJkhw" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="aWekJ2NVAECIIbxJKJ8L5g" visible="0" canBeVaried="0" />
-                      <Parameter id="_X2_o9RNsE-lLaS8Zsopiw" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="2IVWcgM31UCSVl8zMDnDhw" visible="0" canBeVaried="0" />
-                      <Parameter id="t_gPDAHsPkOe7snhonOenQ" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="bOPO_JT8sEOF6PITZSGGVg" visible="0" canBeVaried="0" />
-                      <Parameter id="0JY8yE65UkKc9X9pHDxlyg" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="rb067Seg_U6p_Xq8Mx-1UQ" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Transport id="dthhtrQNy02ngid2p7IzMg" name="DrugAbsorption_trans" description="Drug absorption transcellular" mode="Logical" containerType="Transport" dimension="Amount per time" formula="xN3P_ow3uE6Mh0QqE3mfFg" sourceAmount="xrlOSQNSBk-WGtZ7E-tEYw" targetAmount="27w6YBfNQkyh-7D9Mivddg">
-                        <Children>
-                          <Parameter id="Vmq5yLsvN0WN-tPV-IoNvw" name="ProcessRate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="0DrAGJwZKE2kMvlT31wnmg" visible="0" canBeVaried="1" displayUnit="µmol/min">
-                            <Tags>
-                              <Tag value="DrugAbsorption_trans" />
-                              <Tag value="ProcessRate" />
-                              <Tag value="C1" />
-                              <Tag value="Lumen_uil_UpperIleum_cell" />
-                              <Tag value="Passive" />
-                            </Tags>
-                          </Parameter>
-                        </Children>
-                      </Transport>
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="rtGV0Jqx30ihad-RL3mxPg" name="UpperIleum_bc_PortalVein_bc" description="Neighborhood between Upper Ileum/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="PSVoSQGqZEqHtyvSo86Uug" secondNeighbor="V3IajphOTUWt3a2j9_LOZA">
-                <Tags>
-                  <Tag value="Neighborhood: BloodCells / BloodCells" />
-                </Tags>
-                <Children>
-                  <Container id="fGWSdS0O5kO1XAd5wtb62Q" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="ir7RQIcTqkm6bPeIlXp_PQ" name="Mass transfer rate (mucosa to portal vein blood cells)" description="Mass transfer rate (mucosa to portal vein blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="IBM9Cmp92Uyp_WVmnJhJBQ" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Transport id="b59r0rlvHkSi17Xl1Juvxw" name="MassTransferMucosaToPveBC" description="Mass transfer from Mucosa:Blood Cells To Portal Vein: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="hiEIHKbqKkicuHpdsXQOVw" sourceAmount="AmS23HbI_0aVgZpvEhgrww" targetAmount="3A4PxVITtUOpr85RBMQZlg" />
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="2pq9xBAfek2xfQKEhy40sQ" name="Lumen_uil_UpperIleum_pls" description="Neighborhood between Lumen/Upper Ileum and Mucosa/Upper Ileum/Plasma" mode="Logical" containerType="Other" firstNeighbor="Ybii6aaw1UeIsuUX1COdYA" secondNeighbor="wiKdxf5lkUaXODbbzJ_MgA">
-                <Tags>
-                  <Tag value="Neighborhood: UpperIleum / Plasma" />
-                </Tags>
-                <Children>
-                  <Container id="svzNWWrrdkeraxA0d5BqpA" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="PcchVNBD3kqiCmsw397hMw" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="WgCWQfCSXU6X-a7JOvmsGA" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Parameter id="-nLlhetY00GWcWOkFrB08Q" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="tnoo6SeFz0ie_MIfokWwHg" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Parameter id="ouKkjfWIeUu_LVYoFg_I2g" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="_nGtS8otok6jEHNBkSz9Kg" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Transport id="RVQubQzkXEeCVsLwuJJSHg" name="DrugAbsorption_para" description="Drug absorption paracellular" mode="Logical" containerType="Transport" dimension="Amount per time" formula="4n6-GddPF02Pc3OaqwGJ7g" sourceAmount="xrlOSQNSBk-WGtZ7E-tEYw" targetAmount="OH4tJOZD_USLmfI7ahxt3w">
-                        <Children>
-                          <Parameter id="kZmNEirr8EOB-CV7P7QAAw" name="ProcessRate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="X3l2X93frES1QiGV5hXexw" visible="0" canBeVaried="1" displayUnit="µmol/min">
-                            <Tags>
-                              <Tag value="DrugAbsorption_para" />
-                              <Tag value="ProcessRate" />
-                              <Tag value="C1" />
-                              <Tag value="Lumen_uil_UpperIleum_pls" />
-                              <Tag value="Passive" />
-                            </Tags>
-                          </Parameter>
-                        </Children>
-                      </Transport>
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="QtIjwBiahUWf7ichbynnpg" name="SmallIntestine_bc_LowerJejunum_bc" description="Neighborhood between Small Intestine/Blood Cells_ and Lower Jejunum/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="BO_2kdQ94EefqAdvRA1T2Q" secondNeighbor="kDMQj4cgPkq4YoBI6vj_HA">
-                <Tags>
-                  <Tag value="Neighborhood: BloodCells / BloodCells" />
-                </Tags>
-                <Children>
-                  <Container id="uCeRtT1MtUuFr0osY9IWiA" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="0SMyM2wMmkCn1-Vzc8GXxA" name="Mass transfer rate (intestine to mucosa blood cells)" description="Mass transfer rate (intestine to mucosa blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="ptA0QQ34VUGC-OOmWJWxNQ" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Transport id="RrfyhBHlxEakLm22V0_Vhg" name="MassTransferSINToMucosaBC" description="Mass transfer from Small Intestine:Blood Cells to Mucosa: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="LDCD1nle-06Xx--7307xNA" sourceAmount="gACrDjDg5UuEdDtbqzvxDA" targetAmount="6Aqs6_wfI0OKiplexvNuNQ" />
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="tFQQ21zO40GNNpcKpC0YHg" name="SmallIntestine_pls_LowerJejunum_pls" description="Neighborhood between Small Intestine/Plasma_ and Lower Jejunum/Plasma" mode="Logical" containerType="Other" firstNeighbor="v7QydXWpf0-VYKE0_MwWVQ" secondNeighbor="qnwzbs7P1EuiOU6I1AbUmw">
-                <Tags>
-                  <Tag value="Neighborhood: Plasma / Plasma" />
-                </Tags>
-                <Children>
-                  <Container id="kMDwBClHlUyoUqIhVksE_g" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="DvdZ-M0I0EqEAThSy68WqQ" name="Mass transfer rate (intestine to mucosa plasma)" description="Mass transfer rate (intestine to mucosa plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="lRnlnmaKmU-zwzPIZef0XQ" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Transport id="feS-bcmj3U2NPKvaq9LMVg" name="MassTransferSINToMucosaPlasma" description="Mass transfer from Small Intestine:Plasma to Mucosa: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="Fglq1HI_TkuT_obV28dZ3g" sourceAmount="f8G7zu_9zEK_ZkVtpIfeVw" targetAmount="YgLswliwdkSHukAAVZwL5w" />
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="Jgi8PNoGU0WKJIeNhjKewA" name="SmallIntestine_bc_UpperIleum_bc" description="Neighborhood between Small Intestine/Blood Cells_ and Upper Ileum/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="BO_2kdQ94EefqAdvRA1T2Q" secondNeighbor="PSVoSQGqZEqHtyvSo86Uug">
-                <Tags>
-                  <Tag value="Neighborhood: BloodCells / BloodCells" />
-                </Tags>
-                <Children>
-                  <Container id="h6-CfiOwJE2a4HYurBxdkQ" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="GZbw-ZakGkmZIS9Z5zszTQ" name="Mass transfer rate (intestine to mucosa blood cells)" description="Mass transfer rate (intestine to mucosa blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="Kgz7pU0kBUaoZOKpvCEPKA" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Transport id="dUrJU0XBMkq-GU5UB825UQ" name="MassTransferSINToMucosaBC" description="Mass transfer from Small Intestine:Blood Cells to Mucosa: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="avdZP6lfnE6b-sQ1SHBFAw" sourceAmount="gACrDjDg5UuEdDtbqzvxDA" targetAmount="AmS23HbI_0aVgZpvEhgrww" />
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="wP2-yYDsEUGNXo65W02KKg" name="SmallIntestine_bc_UpperJejunum_bc" description="Neighborhood between Small Intestine/Blood Cells_ and Upper Jejunum/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="BO_2kdQ94EefqAdvRA1T2Q" secondNeighbor="BiBid5i4Sk2EK94scFpeHw">
-                <Tags>
-                  <Tag value="Neighborhood: BloodCells / BloodCells" />
-                </Tags>
-                <Children>
-                  <Container id="tyxbHEFVeECGNMHb8goX7Q" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="ji9PYrzJukuBFdWgoO-COw" name="Mass transfer rate (intestine to mucosa blood cells)" description="Mass transfer rate (intestine to mucosa blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="dmIJ2c4h9kOemKrjJE9zFw" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Transport id="HuN-1FEr5ku_mu3kcJ-z7w" name="MassTransferSINToMucosaBC" description="Mass transfer from Small Intestine:Blood Cells to Mucosa: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="fU-VEUqj8UuH4DO0agpjnQ" sourceAmount="gACrDjDg5UuEdDtbqzvxDA" targetAmount="RgAh2V1O4EKEVX6UAhe4zQ" />
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="CaLPuOLMSE2qY5WMNTy2dA" name="SmallIntestine_pls_UpperJejunum_pls" description="Neighborhood between Small Intestine/Plasma_ and Upper Jejunum/Plasma" mode="Logical" containerType="Other" firstNeighbor="v7QydXWpf0-VYKE0_MwWVQ" secondNeighbor="Mqff24qDg0q3J5knCoXTZw">
-                <Tags>
-                  <Tag value="Neighborhood: Plasma / Plasma" />
-                </Tags>
-                <Children>
-                  <Container id="uPFAOfvO20OjE8HzT44D6A" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="u53uURKDeEivzHM_BdqDMg" name="Mass transfer rate (intestine to mucosa plasma)" description="Mass transfer rate (intestine to mucosa plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="nAMRbkvlL0umGB77Wp7CrQ" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Transport id="xm2V-92ZVU6RIbxja7G7Kg" name="MassTransferSINToMucosaPlasma" description="Mass transfer from Small Intestine:Plasma to Mucosa: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="w96jflKD80WgwLzH6USUIQ" sourceAmount="f8G7zu_9zEK_ZkVtpIfeVw" targetAmount="PMNegnlhr0CXVnvfwhXU7g" />
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="aP0iAYiGS0Wi--LDtl9IeQ" name="SmallIntestine_bc_Duodenum_bc" description="Neighborhood between Small Intestine/Blood Cells_ and Duodenum/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="BO_2kdQ94EefqAdvRA1T2Q" secondNeighbor="TdV1_un1aESakxFEr6GkQw">
-                <Tags>
-                  <Tag value="Neighborhood: BloodCells / BloodCells" />
-                </Tags>
-                <Children>
-                  <Container id="Tz_meUw0NEGXMlt155IShA" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="gvOnq7oi8EGDHV4l_saXYw" name="Mass transfer rate (intestine to mucosa blood cells)" description="Mass transfer rate (intestine to mucosa blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="4feUEzURQE-toxYNBqWajw" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Transport id="BtNhElmbPEuDb-sEU2_3kA" name="MassTransferSINToMucosaBC" description="Mass transfer from Small Intestine:Blood Cells to Mucosa: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="iJ7vqHHIp06Q_CS6F-CUjw" sourceAmount="gACrDjDg5UuEdDtbqzvxDA" targetAmount="F5meuBt0ck6H-U7fLJ-DUg" />
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="71UVVQJtlE-4QrM-qUYsFw" name="SmallIntestine_pls_Duodenum_pls" description="Neighborhood between Small Intestine/Plasma_ and Duodenum/Plasma" mode="Logical" containerType="Other" firstNeighbor="v7QydXWpf0-VYKE0_MwWVQ" secondNeighbor="5qa_dNfzPEqENSftAboAkA">
-                <Tags>
-                  <Tag value="Neighborhood: Plasma / Plasma" />
-                </Tags>
-                <Children>
-                  <Container id="iyrWpS44u0atLcFnqfxTnw" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="Q_h55imW80qnudR3Awnb-Q" name="Mass transfer rate (intestine to mucosa plasma)" description="Mass transfer rate (intestine to mucosa plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="x16INAER3kGyaKaBWPZ3tw" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Transport id="LKmr51zaOkKc2gOk0lT4Tw" name="MassTransferSINToMucosaPlasma" description="Mass transfer from Small Intestine:Plasma to Mucosa: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="QT8CjBIzbEij_1L_VHUG6w" sourceAmount="f8G7zu_9zEK_ZkVtpIfeVw" targetAmount="9U0qncgJp0GzhMN51sFuvg" />
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="4JKBb1pg9EKbJzYIrGB7IQ" name="SmallIntestine_pls_UpperIleum_pls" description="Neighborhood between Small Intestine/Plasma_ and Upper Ileum/Plasma" mode="Logical" containerType="Other" firstNeighbor="v7QydXWpf0-VYKE0_MwWVQ" secondNeighbor="wiKdxf5lkUaXODbbzJ_MgA">
-                <Tags>
-                  <Tag value="Neighborhood: Plasma / Plasma" />
-                </Tags>
-                <Children>
-                  <Container id="jeEP_yiNlkCv3gTxs1WxIQ" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="N6h3icP3OkqnLMZvedNIPg" name="Mass transfer rate (intestine to mucosa plasma)" description="Mass transfer rate (intestine to mucosa plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="HRPREU-OG0aYOVfI0qZqkg" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Transport id="d8z8SvQlbk2K4stRZZdERw" name="MassTransferSINToMucosaPlasma" description="Mass transfer from Small Intestine:Plasma to Mucosa: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="YnNfy-kj7kq-8-V1ntFVMw" sourceAmount="f8G7zu_9zEK_ZkVtpIfeVw" targetAmount="OH4tJOZD_USLmfI7ahxt3w" />
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="z3hrT9Lf50KF-DbEF1AMSQ" name="LowerIleum_bc_PortalVein_bc" description="Neighborhood between Lower Ileum/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="NNtCjKsDKEmpfBZtoykFkw" secondNeighbor="V3IajphOTUWt3a2j9_LOZA">
-                <Tags>
-                  <Tag value="Neighborhood: BloodCells / BloodCells" />
-                </Tags>
-                <Children>
-                  <Container id="m-XxHFUgdkSJ_3b3QKSAvQ" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="tCKLkvErFk2BJMY_0L72zw" name="Mass transfer rate (mucosa to portal vein blood cells)" description="Mass transfer rate (mucosa to portal vein blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="GuLJp58VbU2RY9pGxlkIzA" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Transport id="JYf0711SDUiIypmf_xKdDw" name="MassTransferMucosaToPveBC" description="Mass transfer from Mucosa:Blood Cells To Portal Vein: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="riRhHks1Wki8WOZHnmOTpQ" sourceAmount="o1HQX8-RRUmWuRf1rvmfuA" targetAmount="3A4PxVITtUOpr85RBMQZlg" />
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="xxZT42xqKUev9XV1XXhw4w" name="LowerIleum_pls_PortalVein_pls" description="Neighborhood between Lower Ileum/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="rrdHQQGA002quyiJj14SNw" secondNeighbor="-zX9e5Gif0qLF9-buV_xlA">
-                <Tags>
-                  <Tag value="Neighborhood: Plasma / Plasma" />
-                </Tags>
-                <Children>
-                  <Container id="D7CUPI2zkkSymAuZ0cBLYg" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="ORxWCz-5XE2HtHFVE7kyLg" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="AnYjeRDBK02LCMCVXtouAg" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Transport id="2i5Xyv3fXU-AByNwy9giBA" name="MassTransferMucosaToPvePlasma" description="Mass transfer from Mucosa:Plasma To Portal Vein: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="S1yRX0JwDUCtWkNzhEXFJg" sourceAmount="0cutZov5eEiqqp_uiBzdtw" targetAmount="hqBDuJ9j9Eqjy73I0KZSUA" />
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="X-_N7GbiPUWBXt0OW47gVw" name="SmallIntestine_bc_LowerIleum_bc" description="Neighborhood between Small Intestine/Blood Cells_ and Lower Ileum/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="BO_2kdQ94EefqAdvRA1T2Q" secondNeighbor="NNtCjKsDKEmpfBZtoykFkw">
-                <Tags>
-                  <Tag value="Neighborhood: BloodCells / BloodCells" />
-                </Tags>
-                <Children>
-                  <Container id="VQJeq5mpdUO_YqVFkruvTQ" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="uXdTzW0_30GvXb-y0OUVxg" name="Mass transfer rate (intestine to mucosa blood cells)" description="Mass transfer rate (intestine to mucosa blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="ri_HmQNAp0uuuNjwDIFEXw" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Transport id="Fn5ebeX9rkOCiqNjs6H7DQ" name="MassTransferSINToMucosaBC" description="Mass transfer from Small Intestine:Blood Cells to Mucosa: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="-I2bD11MPkyX1buVWa8Ztg" sourceAmount="gACrDjDg5UuEdDtbqzvxDA" targetAmount="o1HQX8-RRUmWuRf1rvmfuA" />
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="pK0CQaahp0W1tm9t4cr7kQ" name="SmallIntestine_pls_LowerIleum_pls" description="Neighborhood between Small Intestine/Plasma_ and Lower Ileum/Plasma" mode="Logical" containerType="Other" firstNeighbor="v7QydXWpf0-VYKE0_MwWVQ" secondNeighbor="rrdHQQGA002quyiJj14SNw">
-                <Tags>
-                  <Tag value="Neighborhood: Plasma / Plasma" />
-                </Tags>
-                <Children>
-                  <Container id="okn5sd3YtEaiKID8nzJhog" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="ESTGJtkTgU28OpAMy2seVg" name="Mass transfer rate (intestine to mucosa plasma)" description="Mass transfer rate (intestine to mucosa plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="to7IsKyUTk6fTmGjVGBl0Q" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Transport id="YDyPnw_BaEq5MwicgtPPFw" name="MassTransferSINToMucosaPlasma" description="Mass transfer from Small Intestine:Plasma to Mucosa: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="1SIYnEGAIU6QRG0t9Cn1VQ" sourceAmount="f8G7zu_9zEK_ZkVtpIfeVw" targetAmount="0cutZov5eEiqqp_uiBzdtw" />
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="Hw6F-s0NPUiVigabbpYeOA" name="Lumen_lil_LowerIleum_cell" description="Neighborhood between Lumen/Lower Ileum and Mucosa/Lower Ileum/Intracellular" mode="Logical" containerType="Other" firstNeighbor="igIrhkz7s0ehw7sHmKiBCg" secondNeighbor="sI2lB80kS0qpJ8_ruusBLA">
-                <Tags>
-                  <Tag value="Neighborhood: LowerIleum / Intracellular" />
-                </Tags>
-                <Children>
-                  <Container id="p1rMaqu2EUGm4nIdPu-qvA" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="wwgYUqyxzk2JCXA1H4ue1Q" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="6yvyCekFy02AoCb1KS0bNg" visible="0" canBeVaried="0" />
-                      <Parameter id="e_ey_3qtMke8XydDFQynmA" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="7bufxjr5EE6MKHH6bTNJVg" visible="0" canBeVaried="0" />
-                      <Parameter id="2R-yJfdl00mkIc7xCUoX6g" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="PEhoVdLppU-G3xULjX_71g" visible="0" canBeVaried="0" />
-                      <Parameter id="0eyrpUiemUGKsqDNsKjQrg" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="pGvG5UNdC0Sot3_d3Qdvag" visible="0" canBeVaried="0" />
-                      <Parameter id="HLkWJ9wzxkm3rJdBpjVt0g" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="jJfeJ2YxEki9TK9XP6uUMA" visible="0" canBeVaried="0" />
-                      <Parameter id="fr8v30kLBUaJfm9010shxQ" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DNF0kWPUFk-rtSd0Ng1Mkw" visible="0" canBeVaried="0" />
-                      <Parameter id="qunvExK3FUamhk_vmH_kCQ" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="gxoZyuApjEuzsuLtZuZWmQ" visible="0" canBeVaried="0" />
-                      <Parameter id="PjJqfPQXdkeWQEkbozMmaA" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="qr_x2cq_Y0C6Ur-VSCP4AQ" visible="0" canBeVaried="0" />
-                      <Parameter id="eZQ8EF1_4EmRYG6ebkeJog" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Iph7YhQ5KUmsZWUX2Xf2Wg" visible="0" canBeVaried="0" />
-                      <Parameter id="kAUCxoxzn0ilzRmcWySLFw" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="aWekJ2NVAECIIbxJKJ8L5g" visible="0" canBeVaried="0" />
-                      <Parameter id="wr_R161pd0qk5ifmkK07Jg" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="A0aQLJr2u0KYdAl8yqWuhQ" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Parameter id="vyh46hMUmEOhAjoudPx8kA" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DNGx_vFWp0KdOb7CGcoTLQ" visible="0" canBeVaried="0" />
-                      <Parameter id="mRTGHmMEAUq4JNRGH6e40Q" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="fxt9xx8-IkaoWUebIvr9xw" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Parameter id="pk6p687ZpE-eltvFYnvt4w" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="aZYSS2yfyEqUEbGBDu38yg" visible="0" canBeVaried="0" />
-                      <Parameter id="dtm9iY75zESnjE3MBaaUcw" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="c3Aogzme0EybAaIYpcxFRg" visible="0" canBeVaried="0" />
-                      <Parameter id="82PgXufq3Um5H0caX6G7uw" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="bOPO_JT8sEOF6PITZSGGVg" visible="0" canBeVaried="0" />
-                      <Parameter id="KJ1ZMSov2ECDtweFWyVDiA" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="LcUCvhU3W0udtbpS1KVhEQ" visible="0" canBeVaried="0" />
-                      <Parameter id="EhXcha1dDkOOwAD1U2uciw" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="PC0-TBuXhE2pjXu4jlfXrg" visible="0" canBeVaried="0" />
-                      <Parameter id="e9hGsO8nBkeaTEThRAJwCA" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="H8USh-gL7U2EdilSgltpGA" visible="0" canBeVaried="1" />
-                      <Parameter id="rX4NWpE_HUGZ-5cUYaAiog" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="xiu_aoVcGE-9JeD7_mV-Kg" visible="0" canBeVaried="0" />
-                      <Parameter id="i8A2vbVLT0GeYaUGnCKq_w" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="LissaqOMkEK06YDfKnQX_A" visible="0" canBeVaried="0" />
-                      <Parameter id="c42mmCsj1ky7XXb7P0KSOw" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="535_NipLs0qp_ynyEh4LIg" visible="0" canBeVaried="0" />
-                      <Parameter id="2SwN8cS6c0SS7t7O0EnQlw" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="0IIh6FJV0UKyrimES0f1xg" visible="0" canBeVaried="0" />
-                      <Parameter id="HlNk3GLlxkCGVX0aLezOtw" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="KQgllSQtqk2EfhX37WilDQ" visible="0" canBeVaried="0" />
-                      <Parameter id="LP_ONyqJdkCSU8PtYO95cQ" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="7NEiCDSKM0i6GhEpoWb-Mw" visible="0" canBeVaried="0" />
-                      <Parameter id="S5VO6DF8cU2tHxvpn9l-Lw" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="3xvkxp6qK06bn4DgEtYULA" visible="0" canBeVaried="0" />
-                      <Parameter id="6bA8A0pzPkuGAfu6AGoL7g" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="ezAHDPnckEKYf8L1jOtGfw" visible="0" canBeVaried="0" />
-                      <Parameter id="eNH_svdzek-fiDDyWaeIdQ" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="2IVWcgM31UCSVl8zMDnDhw" visible="0" canBeVaried="0" />
-                      <Parameter id="HzmVU99QjES5CQrBY9OHUA" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="ig03653Uq0mqU7VB97iodA" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Transport id="ODrE40_ABkSj6vfmwQeoEw" name="DrugAbsorption_trans" description="Drug absorption transcellular" mode="Logical" containerType="Transport" dimension="Amount per time" formula="ta2k6vnbSEWLMaKZF5zw_g" sourceAmount="yw7rzbgJB0-l91_K8hz0sQ" targetAmount="2dcifeUtpkujhqGqlE3Qnw">
-                        <Children>
-                          <Parameter id="obRSMCGE3UCHEG7EXZJxog" name="ProcessRate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="kssVugh9FkGjcfPwnlTRRg" visible="0" canBeVaried="1" displayUnit="µmol/min">
-                            <Tags>
-                              <Tag value="DrugAbsorption_trans" />
-                              <Tag value="ProcessRate" />
-                              <Tag value="C1" />
-                              <Tag value="Lumen_lil_LowerIleum_cell" />
-                              <Tag value="Passive" />
-                            </Tags>
-                          </Parameter>
-                        </Children>
-                      </Transport>
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="1YO-OaT3fk6gl2niNlRdhg" name="Lumen_lil_LowerIleum_pls" description="Neighborhood between Lumen/Lower Ileum and Mucosa/Lower Ileum/Plasma" mode="Logical" containerType="Other" firstNeighbor="igIrhkz7s0ehw7sHmKiBCg" secondNeighbor="rrdHQQGA002quyiJj14SNw">
-                <Tags>
-                  <Tag value="Neighborhood: LowerIleum / Plasma" />
-                </Tags>
-                <Children>
-                  <Container id="rMdJ24x7dk273D5cGaLhLA" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="LnKNq8wFoU2O79fzmg50Wg" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="xj_Y24-PJECv7YHTavI5Ig" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Parameter id="gGOY8G_ILk69meL6Lpjq3g" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="IZiQhxuVi0SK2DlgOu8Nfw" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Parameter id="ukWFn2EkvEikILWwFhfzCQ" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="lNtv9aqONkOsQB0JKc_1TQ" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Transport id="GviVQxrwZkCHxbU4pVRiqw" name="DrugAbsorption_para" description="Drug absorption paracellular" mode="Logical" containerType="Transport" dimension="Amount per time" formula="PjB0uQ9mEkGOh9kL03EJ3A" sourceAmount="yw7rzbgJB0-l91_K8hz0sQ" targetAmount="0cutZov5eEiqqp_uiBzdtw">
-                        <Children>
-                          <Parameter id="mTDGLhWG8kWK3x7Mu--hng" name="ProcessRate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="ll4JNT9-6kOrJf8QXfqM9Q" visible="0" canBeVaried="1" displayUnit="µmol/min">
-                            <Tags>
-                              <Tag value="DrugAbsorption_para" />
-                              <Tag value="ProcessRate" />
-                              <Tag value="C1" />
-                              <Tag value="Lumen_lil_LowerIleum_pls" />
-                              <Tag value="Passive" />
-                            </Tags>
-                          </Parameter>
-                        </Children>
-                      </Transport>
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="ojFIxqKn5E-oMGUDzdGBnA" name="SmallIntestine_int_SmallIntestine_cell" description="Neighborhood between Small Intestine/Interstitial and Small Intestine/Intracellular" mode="Logical" containerType="Other" firstNeighbor="ilLnP1DOPkuzNEpG7Fv3Lg" secondNeighbor="OHqsp3isJUGXVMaVk0iHQg">
-                <Tags>
-                  <Tag value="Neighborhood: Interstitial / Intracellular" />
-                  <Tag value="Small intestine  neighborhood" />
-                </Tags>
-                <Children>
-                  <Container id="nXX62em9zEqkPIf1I8S-iQ" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="oQz19CjiWES9-qWyqX_PNQ" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="BtYHf38KbE2Woag0S8zVQw" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                      <Parameter id="z7k9zSkt7kWPPctb17_ZTg" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="Y5i-HZk9NUeoA7UKGgQIDg" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                      <Parameter id="kj_A0HCHNEykiZZHEIIR8A" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="hKXq5MVtGkCKHD0_pgT1Kg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                      <Parameter id="fprSINi3d0e0MmyyXxl-uw" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="p_bsa76dkkG6bsceP87FTg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                      <Parameter id="VT8CVkMxwk-dWHdAsde3Zw" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                      <Parameter id="Y77Bki6B70SaM0XqmEc2jw" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                      <Parameter id="OrPVrVWxQkaJ1sq9pyw54Q" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="v-1sIkNZfUC3FjD2xOQCfQ" visible="1" canBeVaried="1" />
-                      <Parameter id="Wy28xRz12EOdyU_HIC2BOA" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="X8aa6JXQB0-b6a-LH5_Krw" visible="0" canBeVaried="1" />
-                      <Parameter id="zXiSFJZto0WHfqIzMdfOKQ" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="lu4zUH9xWUeBUaDg04lGug" visible="0" canBeVaried="0" />
-                      <Transport id="2gtb4VHK6kqQ-u9n0iOkvA" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Transport" dimension="Amount per time" formula="pSEvqbUT9UyQKq7XT9qRXg" sourceAmount="fclzk6VWh02b904j5Lzyow" targetAmount="HO6kTUalu0Wh1XgMk3T-Vg" />
-                    </Children>
-                  </Container>
-                  <Parameter id="KZmPtRq6_0mGOJkJn5QP0A" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="QtNnwiUTmk-Np7TPdoaKgg" visible="1" canBeVaried="1" displayUnit="cm²" />
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="mor0olxPOEmkcIJ9X6JskA" name="SmallIntestine_pls_SmallIntestine_int" description="Neighborhood between Small Intestine/Plasma and Small Intestine/Interstitial" mode="Logical" containerType="Other" firstNeighbor="v7QydXWpf0-VYKE0_MwWVQ" secondNeighbor="ilLnP1DOPkuzNEpG7Fv3Lg">
-                <Tags>
-                  <Tag value="Neighborhood: Plasma / Interstitial" />
-                  <Tag value="Small intestine  neighborhood" />
-                </Tags>
-                <Children>
-                  <Container id="m1uTViv4gkSRKzWkjw9xhA" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="pQx3IM8gsEi6QBprhP91gA" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Bon9EHArSU6bcCi8KdWj7w" visible="1" canBeVaried="1" />
-                      <Parameter id="nuSSNraCOk-ffF0SFyenjQ" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" visible="1" canBeVaried="1" value="10" displayUnit="cm/min" />
-                      <Transport id="P3rDVoHsMkqxW7kdfwaL0w" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Transport" dimension="Amount per time" formula="PjpOflMrKEaPOTSK--8P2A" sourceAmount="f8G7zu_9zEK_ZkVtpIfeVw" targetAmount="fclzk6VWh02b904j5Lzyow" />
-                    </Children>
-                  </Container>
-                  <Parameter id="lgOeiYG86EuzBRWGhAI7vg" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="dFogA47WSESKRhUF1p4IOQ" visible="1" canBeVaried="1" displayUnit="cm²" />
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="gJtZTXKatUmDuypmruIpqw" name="SmallIntestine_pls_SmallIntestine_bc" description="Neighborhood between Small Intestine/Plasma and Small Intestine/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="v7QydXWpf0-VYKE0_MwWVQ" secondNeighbor="BO_2kdQ94EefqAdvRA1T2Q">
-                <Tags>
-                  <Tag value="Neighborhood: Plasma / BloodCells" />
-                  <Tag value="Small intestine  neighborhood" />
-                </Tags>
-                <Children>
-                  <Container id="u9plvh2X6U6XAVYR1MivGw" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Transport id="rQd5MiqTb0CcjzDt-zJW6A" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="Vl_x-4jt9kabiX4Bw3oMEw" sourceAmount="f8G7zu_9zEK_ZkVtpIfeVw" targetAmount="gACrDjDg5UuEdDtbqzvxDA" />
-                    </Children>
-                  </Container>
-                  <Parameter id="Rjlzhx3JtEecBd1FLoFhVg" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="sZqHki5_PUeVDCO3BU08dw" visible="1" canBeVaried="1" displayUnit="cm²" />
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="6aMpTJu8C0Sn0sFZysPfEQ" name="SmallIntestine_pls_PortalVein_pls" description="Neighborhood between Small Intestine/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="v7QydXWpf0-VYKE0_MwWVQ" secondNeighbor="-zX9e5Gif0qLF9-buV_xlA">
-                <Tags>
-                  <Tag value="Neighborhood: Plasma / Plasma" />
-                </Tags>
-                <Children>
-                  <Container id="mpWvkUq4pUOAy1jUvFvXaA" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Transport id="R1HTMuwE0Uq32K2HvKv6HA" name="MassTransferSinPlasma2BloodPool_Pve" description="Mass transfer from Small Intestine:Plasma to Portal Vein: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="9-JifV5_wUmE9niDo6bIIQ" sourceAmount="f8G7zu_9zEK_ZkVtpIfeVw" targetAmount="hqBDuJ9j9Eqjy73I0KZSUA" />
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="fntZLUBYQkKSmYrLz-YxWQ" name="SmallIntestine_bc_PortalVein_bc" description="Neighborhood between Small Intestine/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="BO_2kdQ94EefqAdvRA1T2Q" secondNeighbor="V3IajphOTUWt3a2j9_LOZA">
-                <Tags>
-                  <Tag value="Neighborhood: BloodCells / BloodCells" />
-                </Tags>
-                <Children>
-                  <Container id="YOKt8IsWi0qyTxkNdtYfNg" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Transport id="Lw2C4DPmLk-ZOnB3cUWLjg" name="MassTransferSinRBC2BloodPool_Pve" description="Mass transfer from Small Intestine:Blood Cells to Portal Vein: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="4-cg3mAlGkqJItow_SlCuw" sourceAmount="gACrDjDg5UuEdDtbqzvxDA" targetAmount="3A4PxVITtUOpr85RBMQZlg" />
-                    </Children>
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-              <Neighborhood id="u8aLQ2rXxUSeJ5J1_p8UNg" name="LargeIntestine_bc_PortalVein_bc" description="Neighborhood between Large Intestine/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="SXH64aI-W0uPsXU5nSDPlA" secondNeighbor="V3IajphOTUWt3a2j9_LOZA">
-                <Tags>
-                  <Tag value="Neighborhood: BloodCells / BloodCells" />
-                </Tags>
-                <Children>
-                  <Container id="i7zFIWaKZ0qtaVjp_6JFAA" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Transport id="JZukBRGx40GQFtPeFm9GRw" name="MassTransferLinRBC2BloodPool_Pve" description="Mass transfer from Large Intestine to Portal Vein: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="tbMSKAkkw0aY4PSX1mWAsw" sourceAmount="1CoHmlwfmEyD48lxr-SSNg" targetAmount="3A4PxVITtUOpr85RBMQZlg" />
-                    </Children>
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-              </Neighborhood>
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-                <Tags>
-                  <Tag value="Neighborhood: BloodCells / BloodCells" />
-                </Tags>
-                <Children>
-                  <Container id="LYKGDH9y_0mt2SxJF8ZKlA" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="aFYPSVQOS0S-t67qVdPgqg" name="Mass transfer rate (intestine to mucosa blood cells)" description="Mass transfer rate (intestine to mucosa blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="j_jOiaMy_Uio2qnHNnw-DA" visible="0" canBeVaried="0" displayUnit="µmol/min" />
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-              <Neighborhood id="XLYV_hHZlUWxPumuTKtL-w" name="LargeIntestine_pls_Rectum_pls" description="Neighborhood between Large Intestine/Plasma_ and Rectum/Plasma" mode="Logical" containerType="Other" firstNeighbor="uvQs1PS9aUqsBpd5BT5HkA" secondNeighbor="WMIBikKwrEe1vMFMiv-ong">
-                <Tags>
-                  <Tag value="Neighborhood: Plasma / Plasma" />
-                </Tags>
-                <Children>
-                  <Container id="Va0AJx4AZkCU_BAC96h3FQ" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="9HgbeJZIsUaQGmc9_ze-Fw" name="Mass transfer rate (intestine to mucosa plasma)" description="Mass transfer rate (intestine to mucosa plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="lwky6E87WEy3zUzIo_e0Wg" visible="0" canBeVaried="0" displayUnit="µmol/min" />
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-                <Tags>
-                  <Tag value="Neighborhood: BloodCells / BloodCells" />
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-                <Children>
-                  <Container id="4BqbZEbJrkmwoksjUYkZ5w" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="Gt3E4KboK0SHUTtnboc1hA" name="Mass transfer rate (intestine to mucosa blood cells)" description="Mass transfer rate (intestine to mucosa blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="3AwjB37suEaHd46cOmSCZg" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Transport id="q4Us0bV1v0qB80HbhKuOcg" name="MassTransferLINToMucosaBC" description="Mass transfer from Large Intestine:Blood Cells to Mucosa: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="wq5cwrdSj0u1X59-5DzAWw" sourceAmount="1CoHmlwfmEyD48lxr-SSNg" targetAmount="nPc7HZ7onEeWVXA5yaAQVg" />
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-              <Neighborhood id="OdEwekeJTU681ANmR1zEwg" name="LargeIntestine_pls_ColonSigmoid_pls" description="Neighborhood between Large Intestine/Plasma_ and Colon Sigmoid/Plasma" mode="Logical" containerType="Other" firstNeighbor="uvQs1PS9aUqsBpd5BT5HkA" secondNeighbor="bzYLFyk2JkmtP6F5xOz6QQ">
-                <Tags>
-                  <Tag value="Neighborhood: Plasma / Plasma" />
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-                <Children>
-                  <Container id="DzOvGfyEAUKo-7jPujOKgw" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="JBs_PUOfcUGSnvoeehR3Dw" name="Mass transfer rate (intestine to mucosa plasma)" description="Mass transfer rate (intestine to mucosa plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="eIiLyxWIO0qlj9Q6jugVaA" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Transport id="8VWZ2J2090O4pBZvKhLxSA" name="MassTransferLINToMucosaPlasma" description="Mass transfer from Large Intestine:Plasma to Mucosa: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="ETPOkSZAsU6MAMA5vVKo7g" sourceAmount="xpcrmRU34EqRDnqQj6ZOeA" targetAmount="xTGJR_rEKE6vG1pK_dnKhA" />
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-                <Tags>
-                  <Tag value="Neighborhood: BloodCells / BloodCells" />
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-                <Children>
-                  <Container id="lNrZeGsKIk2gjDz05WCnKw" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="lHh-UYmSr0WkqwzAjAiuoQ" name="Mass transfer rate (intestine to mucosa blood cells)" description="Mass transfer rate (intestine to mucosa blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="cxN41IuZIkKenGapZjnLvA" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Transport id="b3CG2w7trEuUwC0nne3gfQ" name="MassTransferLINToMucosaBC" description="Mass transfer from Large Intestine:Blood Cells to Mucosa: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="snRT01zJ-0C6stVd8X-E9g" sourceAmount="1CoHmlwfmEyD48lxr-SSNg" targetAmount="3eMVtSbfykKuZmsiS31jUg" />
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-              <Neighborhood id="WOiv1jKyhkC8EZZ4jKXRqQ" name="LargeIntestine_pls_ColonDescendens_pls" description="Neighborhood between Large Intestine/Plasma_ and Colon Descendens/Plasma" mode="Logical" containerType="Other" firstNeighbor="uvQs1PS9aUqsBpd5BT5HkA" secondNeighbor="IYSOBD2MW0SByEccir1gtg">
-                <Tags>
-                  <Tag value="Neighborhood: Plasma / Plasma" />
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-                <Children>
-                  <Container id="ZrxeJ1Iff0Wf6DwjV4MdIw" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="gULLBrTfskqyo36G8zHRqw" name="Mass transfer rate (intestine to mucosa plasma)" description="Mass transfer rate (intestine to mucosa plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="pddfpZDG0EiJJRNstRbimQ" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Transport id="Ez59b4czl0CAw_kA65jmXQ" name="MassTransferLINToMucosaPlasma" description="Mass transfer from Large Intestine:Plasma to Mucosa: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="ttE0oBM-U0OY6rO3aVOMYg" sourceAmount="xpcrmRU34EqRDnqQj6ZOeA" targetAmount="fRScY5akTkSbcR1hbKcs5Q" />
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-              <Neighborhood id="wcxARq9v3Uyx7tcgkj9Jkw" name="LargeIntestine_bc_ColonTransversum_bc" description="Neighborhood between Large Intestine/Blood Cells_ and Colon Transversum/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="SXH64aI-W0uPsXU5nSDPlA" secondNeighbor="nK4V9tiRUUy-zjLhRo56OA">
-                <Tags>
-                  <Tag value="Neighborhood: BloodCells / BloodCells" />
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-                <Children>
-                  <Container id="jNX4xNnuDEWz278tfNlEqA" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="v4xaV0RiQ0yeH-tacG_ndQ" name="Mass transfer rate (intestine to mucosa blood cells)" description="Mass transfer rate (intestine to mucosa blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="-9JS7E9W90mSmwgWg77vug" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Transport id="7OHGYGCQ5kakopXKtV3JwQ" name="MassTransferLINToMucosaBC" description="Mass transfer from Large Intestine:Blood Cells to Mucosa: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="SZ7wOz0DI0WTDgFKQRZArA" sourceAmount="1CoHmlwfmEyD48lxr-SSNg" targetAmount="2BQp7lKGjkCgjUSXvOs6QQ" />
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-              <Neighborhood id="pWQjrRInPEGcwptWvi9xfA" name="LargeIntestine_bc_Caecum_bc" description="Neighborhood between Large Intestine/Blood Cells_ and Cecum/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="SXH64aI-W0uPsXU5nSDPlA" secondNeighbor="6kGZy_3g3U-NktadHdhW3Q">
-                <Tags>
-                  <Tag value="Neighborhood: BloodCells / BloodCells" />
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-                <Children>
-                  <Container id="IATX9DZ75U6on67oombIWg" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="h-0tnjWVJk2I1dTDiNmazg" name="Mass transfer rate (intestine to mucosa blood cells)" description="Mass transfer rate (intestine to mucosa blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="ac15oklOqkaYhtrTebA_jg" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Transport id="n_6rAnRaikO1kn36sfHc7Q" name="MassTransferLINToMucosaBC" description="Mass transfer from Large Intestine:Blood Cells to Mucosa: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="eLQGdOkskEysEa-ZdOpu0Q" sourceAmount="1CoHmlwfmEyD48lxr-SSNg" targetAmount="05yORl8O3EeGbBTdKhAhHA" />
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-              <Neighborhood id="xib73lpjPkex-IPh5fUTIg" name="LargeIntestine_pls_ColonTransversum_pls" description="Neighborhood between Large Intestine/Plasma_ and Colon Transversum/Plasma" mode="Logical" containerType="Other" firstNeighbor="uvQs1PS9aUqsBpd5BT5HkA" secondNeighbor="-P41WVvf4kGpY92ttsK8NQ">
-                <Tags>
-                  <Tag value="Neighborhood: Plasma / Plasma" />
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-                <Children>
-                  <Container id="INMHuIYI4Uyp1phMNemzkw" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="4b0EZxlTj0K7-GxxtAQ-Jw" name="Mass transfer rate (intestine to mucosa plasma)" description="Mass transfer rate (intestine to mucosa plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="fyTABT0ry0CSKslXfuvBxw" visible="0" canBeVaried="0" displayUnit="µmol/min" />
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-                <Tags>
-                  <Tag value="Neighborhood: BloodCells / BloodCells" />
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-                <Children>
-                  <Container id="G3ea_k0hek2ceybNy_rrSQ" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="Pp5sSc6A3kevFLd3yzWpGA" name="Mass transfer rate (intestine to mucosa blood cells)" description="Mass transfer rate (intestine to mucosa blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="Xwv2hnSHAUKofFp7fi1dsg" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Transport id="y6jFrBjoKk-iXUKhYbSRkA" name="MassTransferLINToMucosaBC" description="Mass transfer from Large Intestine:Blood Cells to Mucosa: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="x6VaEw44kEGJ_4awYPPNIQ" sourceAmount="1CoHmlwfmEyD48lxr-SSNg" targetAmount="Ls0R4hvRKki76eHKnnDq6g" />
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-              <Neighborhood id="nT7YO3XKokOQ83jWkAid0g" name="LargeIntestine_pls_ColonAscendens_pls" description="Neighborhood between Large Intestine/Plasma_ and Colon Ascendens/Plasma" mode="Logical" containerType="Other" firstNeighbor="uvQs1PS9aUqsBpd5BT5HkA" secondNeighbor="Aivr7qttHUatCWB0Vus_ew">
-                <Tags>
-                  <Tag value="Neighborhood: Plasma / Plasma" />
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-                <Children>
-                  <Container id="yorU7v7GnEO84GnE2oS67w" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="T7k9o93l10-2Vj4IOCCXZQ" name="Mass transfer rate (intestine to mucosa plasma)" description="Mass transfer rate (intestine to mucosa plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="gNUU_sbtp0Gy1vhDetrK1w" visible="0" canBeVaried="0" displayUnit="µmol/min" />
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-              <Neighborhood id="fnGvSTFVHUSLx0I0DL-vFw" name="LargeIntestine_pls_LargeIntestine_bc" description="Neighborhood between Large Intestine/Plasma and Large Intestine/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="uvQs1PS9aUqsBpd5BT5HkA" secondNeighbor="SXH64aI-W0uPsXU5nSDPlA">
-                <Tags>
-                  <Tag value="Large intestine  neighborhood" />
-                  <Tag value="Neighborhood: Plasma / BloodCells" />
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-                <Children>
-                  <Container id="mIGs3ppzP02DOoS1MAljxg" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Transport id="TC1ApgqT1UC3TFSrn_Hk_A" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="tR9dwnJSk0isR00TYQn5lA" sourceAmount="xpcrmRU34EqRDnqQj6ZOeA" targetAmount="1CoHmlwfmEyD48lxr-SSNg" />
-                    </Children>
-                  </Container>
-                  <Parameter id="kVfADRaN0EGpMCeEFZIvmQ" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="LED1mrNSIk-_5q1AyNmQ1A" visible="1" canBeVaried="1" displayUnit="cm²" />
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-                <Tags>
-                  <Tag value="Large intestine  neighborhood" />
-                  <Tag value="Neighborhood: Interstitial / Intracellular" />
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-                <Children>
-                  <Container id="j7cgStaaL0Ou-a9kgu8VzA" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="3hGkl0UdNkK6_RVCRoznag" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="BtYHf38KbE2Woag0S8zVQw" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                      <Parameter id="GwheSER9tEO2NLFITiwBAg" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="Y5i-HZk9NUeoA7UKGgQIDg" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                      <Parameter id="o-KNiK73akO7yctTHh6PHw" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="hKXq5MVtGkCKHD0_pgT1Kg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                      <Parameter id="rEYIVUvvPk6ZMLQQ5JvKKA" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="p_bsa76dkkG6bsceP87FTg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                      <Parameter id="P1QMcOqMzECh6lofcnLRSg" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
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-                      <Parameter id="2qQ0jeq1Ckiq1vuD7gWnHg" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="l67xd6bdyUqAwiTT9QVtCg" visible="1" canBeVaried="1" />
-                      <Parameter id="NvTlxWVsek2QtdcSPqhSjg" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="X8aa6JXQB0-b6a-LH5_Krw" visible="0" canBeVaried="1" />
-                      <Parameter id="VGFqmZNNO0emBSkrkPwsjw" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="2iaBngQgI0qH_r5qEaH-Vg" visible="0" canBeVaried="0" />
-                      <Transport id="80xG66hTTUC05eMXg7GJeQ" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Transport" dimension="Amount per time" formula="7Y1gJ5cMSEO6lwlOqJr93w" sourceAmount="ogyOwK65X0uL1DkZot3EUA" targetAmount="-Vdyhy1qAEGZJkWudpNPKA" />
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-                  <Parameter id="F6gRCObuvEadU4M86E2THg" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="hL1b37KxPky5KAcVFVg3CA" visible="1" canBeVaried="1" displayUnit="cm²" />
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-                <Tags>
-                  <Tag value="Large intestine  neighborhood" />
-                  <Tag value="Neighborhood: Plasma / Interstitial" />
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-                <Children>
-                  <Container id="6XTItnQ-bkKZjhJRF7tmbQ" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="VL1nfjTVp0aqzJFRwoGEIw" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" visible="1" canBeVaried="1" value="10" displayUnit="cm/min" />
-                      <Parameter id="kOGyPRtOAkCVLzWpI017CA" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Bon9EHArSU6bcCi8KdWj7w" visible="1" canBeVaried="1" />
-                      <Transport id="oCgnobI31kmmHlYYiISYow" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Transport" dimension="Amount per time" formula="YSmrQ6ZqPEatTn_w8mCbiw" sourceAmount="xpcrmRU34EqRDnqQj6ZOeA" targetAmount="ogyOwK65X0uL1DkZot3EUA" />
-                    </Children>
-                  </Container>
-                  <Parameter id="rC7ukeajRkCo8_QntT31NA" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="H6x810lWk0mIQL7j67rvZw" visible="1" canBeVaried="1" displayUnit="cm²" />
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="kgDVquKVEkakv2bW1EpozA" name="LargeIntestine_pls_Caecum_pls" description="Neighborhood between Large Intestine/Plasma_ and Cecum/Plasma" mode="Logical" containerType="Other" firstNeighbor="uvQs1PS9aUqsBpd5BT5HkA" secondNeighbor="qk0qF8uZI06cnoMMMXTreA">
-                <Tags>
-                  <Tag value="Neighborhood: Plasma / Plasma" />
-                </Tags>
-                <Children>
-                  <Container id="h-JEc_sEEUqQVZtTrQJkOg" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="fe-QIr0P1UOeC5KJvjjLpw" name="Mass transfer rate (intestine to mucosa plasma)" description="Mass transfer rate (intestine to mucosa plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="wtf0y8SRrUKh_MqnsDuI5w" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Transport id="ADmxoDXV8UKEGhAhpSvILQ" name="MassTransferLINToMucosaPlasma" description="Mass transfer from Large Intestine:Plasma to Mucosa: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="AdChnpk9Lk2OUXhgfSMlSg" sourceAmount="xpcrmRU34EqRDnqQj6ZOeA" targetAmount="Lpte9WeV50K2AalO8MrxAw" />
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="Aob7tBcW3EGaXMQtNOlRzw" name="LargeIntestine_pls_PortalVein_pls" description="Neighborhood between Large Intestine/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="uvQs1PS9aUqsBpd5BT5HkA" secondNeighbor="-zX9e5Gif0qLF9-buV_xlA">
-                <Tags>
-                  <Tag value="Neighborhood: Plasma / Plasma" />
-                </Tags>
-                <Children>
-                  <Container id="qbrQBxuVJ0-J44JarjOyZA" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Transport id="S3EIPNokdkqfnxfbdKTLDA" name="MassTransferLinPlasma2BloodPool_Pve" description="Mass transfer from Large Intestine :Plasma to Portal Vein: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="gQXeLHqH3UWWRMrR3pQciA" sourceAmount="xpcrmRU34EqRDnqQj6ZOeA" targetAmount="hqBDuJ9j9Eqjy73I0KZSUA" />
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="IAQjwnDgTkiQGRkgbCZC8g" name="Liver_pls_Liver_bc" description="Neighborhood between Liver/Plasma and Liver/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="5FNaxPygXkWpARUfOC0rDA" secondNeighbor="5yZ7vQGKrEq4RZIcazhTBQ">
-                <Tags>
-                  <Tag value="Neighborhood: Plasma / BloodCells" />
-                </Tags>
-                <Children>
-                  <Container id="sgwcXqPh_U-cXr6NpW0D8w" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Transport id="RI8SpWqpxEiAj2uru-WOlQ" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="38TepRSTOU-YZDpPCiJUhQ" sourceAmount="T_cXaPk7BEyWVth9NnrBzw" targetAmount="d0NG98bkQ0uyp6XKGUEC_Q" />
-                    </Children>
-                  </Container>
-                  <Parameter id="IkCXd61gNUevNQe-ZATsSQ" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="l_CwIVAygkmSagfFGluFSg" visible="1" canBeVaried="1" displayUnit="cm²" />
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="wxLtOZEk5k-C9CcG44pxQA" name="Liver_pls_VenousBlood_pls" description="Neighborhood between Liver/Plasma and Venous Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="5FNaxPygXkWpARUfOC0rDA" secondNeighbor="J2AzZMiPQUibGWyUqz4XLA">
-                <Tags>
-                  <Tag value="Neighborhood: Plasma / Plasma" />
-                </Tags>
-                <Children>
-                  <Container id="D0jLDXE9rkGqim8Z0XR0Fg" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Transport id="j09A-4x7p0efO4ooc_W-yg" name="MassTransferOrgPl2BloodPool_Liv" description="Mass transfer from Liver: Plasma to Venous Blood: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="xNuAGXoR3EOONLFvaatGYA" sourceAmount="T_cXaPk7BEyWVth9NnrBzw" targetAmount="B3lPdr5IY0uIYf2oKyowmg" />
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="dpKn_yP7OUi8lW81fDQNJg" name="Liver_int_Liver_cell" description="Neighborhood between Liver/Interstitial and Liver/Intracellular" mode="Logical" containerType="Other" firstNeighbor="-H_ruFtnA0yNTMDWFWrpQA" secondNeighbor="paNIIwYocUKqmkMO_9k0pw">
-                <Tags>
-                  <Tag value="Neighborhood: Interstitial / Intracellular" />
-                </Tags>
-                <Children>
-                  <Container id="GuXcpr5VpE--g6lKTWFq_g" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="wnJZ5k2cukS3CloY-NIZdA" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="p_bsa76dkkG6bsceP87FTg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                      <Parameter id="KVRGB5iP90KtJ-2nJzeOhQ" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                      <Parameter id="ws25mmtobEer-Iut_h6vpQ" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="tlPA8QO9g02kkrY1yqEIAQ" visible="1" canBeVaried="1" />
-                      <Parameter id="aDUWKUiwREOyyr152QXLtQ" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="X8aa6JXQB0-b6a-LH5_Krw" visible="0" canBeVaried="1" />
-                      <Parameter id="HifaJXH4JkyMryfZOMMuKQ" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="hKXq5MVtGkCKHD0_pgT1Kg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                      <Parameter id="BeOjvrfTIUCXNnaNn9xy5w" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                      <Parameter id="rHM8Palr7UqD2-Iwf26eMg" name="Min (PA, Q)" description="Minimum between permeability and blood flow" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="TCCFmcpvJkm9vJ5E7hELeQ" visible="0" canBeVaried="0" displayUnit="l/min" />
-                      <Parameter id="Z4cEDOE8cU2vcKfGyXgU3A" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="BtYHf38KbE2Woag0S8zVQw" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                      <Parameter id="81bQ7slT10KF6-QZdE2JrQ" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="Y5i-HZk9NUeoA7UKGgQIDg" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                      <Parameter id="O1AMHwlui0GDoD6ZPnERjg" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="H-ASq1jSF0idEnPTIb2ITg" visible="0" canBeVaried="0" />
-                      <Transport id="Xt66c7QTn0iB6-sCcK3RKw" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Transport" dimension="Amount per time" formula="rCM0XrrEMEukuc2YApE9DQ" sourceAmount="LXffvaTUJkyiFK9g7Yg8Mg" targetAmount="SC75U6vf6UW32_Tid9pjFA" />
-                    </Children>
-                  </Container>
-                  <Parameter id="kzIO9Id9CEK0eMuo0ppsSA" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="EsjgPbxHV0-R3oPr9Rxw2A" visible="1" canBeVaried="1" displayUnit="cm²" />
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="6YSk-JhV2027Q96h3qE59w" name="Liver_pls_Liver_int" description="Neighborhood between Liver/Plasma and Liver/Interstitial" mode="Logical" containerType="Other" firstNeighbor="5FNaxPygXkWpARUfOC0rDA" secondNeighbor="-H_ruFtnA0yNTMDWFWrpQA">
-                <Tags>
-                  <Tag value="Neighborhood: Plasma / Interstitial" />
-                </Tags>
-                <Children>
-                  <Container id="t18jJF5ohUKi-P2DNzRgkg" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="UHtFuXGBDUqUqj_7ol6Mow" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" visible="1" canBeVaried="1" value="10" displayUnit="cm/min" />
-                      <Parameter id="PAo8o-XCAUex5XWnAdRmqA" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Bon9EHArSU6bcCi8KdWj7w" visible="1" canBeVaried="1" />
-                      <Transport id="Ls6VSM9pFEKK698cpCQFrg" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Transport" dimension="Amount per time" formula="TYnvXyuujkm982JYAVtCnQ" sourceAmount="T_cXaPk7BEyWVth9NnrBzw" targetAmount="LXffvaTUJkyiFK9g7Yg8Mg" />
-                    </Children>
-                  </Container>
-                  <Parameter id="8vXoXC2PZEWTDBXSwbumaw" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="DP1GtIeJJESM7zUETJOL3Q" visible="1" canBeVaried="1" displayUnit="cm²" />
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="DTwZOvkfYEqdchnauvp7rw" name="Gallbladder_Lumen_duo" description="Gallbladder and Lumen/Duodenum" mode="Logical" containerType="Other" firstNeighbor="4wG1HdnR90upld7ARMVVbw" secondNeighbor="RBDgGJ__rUCEJi-Z5h0eyg">
-                <Tags>
-                  <Tag value="Neighborhood: Gallbladder / Duodenum" />
-                </Tags>
-                <Children>
-                  <Container id="vBjkc4PFeUCmEBaeWAfI9A" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Transport id="IORss-F35ESdyNCA6BA2fw" name="GallbladderEmptying" description="Gallbladder emptying" mode="Logical" containerType="Transport" dimension="Amount per time" formula="gBElZyhXd0W-JG3tFIzrWA" sourceAmount="kzqdDdO1KkGPTLPLhNAn8Q" targetAmount="BaeHcf6VhUyw3ftOPt1iIg" />
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="XV9NNSPpUUKenvC6umsTFA" name="Liver_cell_Lumen_duo" description="Neighborhood between Liver/Intracellular and Lumen/Duodenum" mode="Logical" containerType="Other" firstNeighbor="paNIIwYocUKqmkMO_9k0pw" secondNeighbor="RBDgGJ__rUCEJi-Z5h0eyg">
-                <Tags>
-                  <Tag value="Neighborhood: Intracellular / Duodenum" />
-                </Tags>
-                <Children>
-                  <Container id="_166zfKWBUWrXRkp_KBM6Q" name="C1" mode="Logical" containerType="Molecule" />
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="e_nPM2UnkkyHaJeAqCOLlg" name="Liver_cell_Gallbladder" description="Neighborhood between Liver/Intracellular and Gallbladder" mode="Logical" containerType="Other" firstNeighbor="paNIIwYocUKqmkMO_9k0pw" secondNeighbor="4wG1HdnR90upld7ARMVVbw">
-                <Tags>
-                  <Tag value="Neighborhood: Intracellular / Gallbladder" />
-                </Tags>
-                <Children>
-                  <Container id="y3jB6lU4VUa-DZQMqp5u6A" name="C1" mode="Logical" containerType="Molecule" />
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="289XPF7szUG4zIAbEn6UxA" name="Liver_bc_VenousBlood_bc" description="Neighborhood between Liver/Blood Cells and Venous Blood/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="5yZ7vQGKrEq4RZIcazhTBQ" secondNeighbor="HLhY21FI2UuJWgRMTu6RlA">
-                <Tags>
-                  <Tag value="Neighborhood: BloodCells / BloodCells" />
-                </Tags>
-                <Children>
-                  <Container id="PkesQeHNTEafg0xJ9mLZFA" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Transport id="LIudNZgtGUynm2MBTwgLoQ" name="MassTransferOrgRBC2BloodPool_Liv" description="Mass transfer from Liver: Blood Cells to Venous Blood: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="GzVEjqnOUUyvO1EI-E1Uxw" sourceAmount="d0NG98bkQ0uyp6XKGUEC_Q" targetAmount="GWJuEfO1Xkqh3wAfzsLyqQ" />
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="DgS-zE99CUKcBtxW4_nveQ" name="Lung_pls_Lung_bc" description="Neighborhood between Lung/Plasma and Lung/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="HoKbo31Lg0yRHlM9oyiwmQ" secondNeighbor="bR9hD2e26EiSVp_aH2gLlA">
-                <Tags>
-                  <Tag value="Neighborhood: Plasma / BloodCells" />
-                </Tags>
-                <Children>
-                  <Container id="fywF993fBEmlAsGB9pT2Lw" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Transport id="PNtcB1zSf0iUQIxw_ym_oA" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="beJz03zeXkm9uq3fDT5BBA" sourceAmount="gbZpi5a1-EC-twcuHrfa2Q" targetAmount="Al9BXU4-TkesaoCcONO8ow" />
-                    </Children>
-                  </Container>
-                  <Parameter id="IU6gIGqmHEyWCBxGHT7LKg" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="3tLcsT3eBEexebrV-ULsqQ" visible="1" canBeVaried="1" displayUnit="cm²" />
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="xjeUdggf20u9fJR2kCDPHA" name="Lung_pls_Lung_int" description="Neighborhood between Lung/Plasma and Lung/Interstitial" mode="Logical" containerType="Other" firstNeighbor="HoKbo31Lg0yRHlM9oyiwmQ" secondNeighbor="92JykqpZS0GTuPIIOzwT1A">
-                <Tags>
-                  <Tag value="Neighborhood: Plasma / Interstitial" />
-                </Tags>
-                <Children>
-                  <Container id="YyQUj3bevkmuB_BJz-XLdw" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="DYkG0UD9w0O7wo170I1cJA" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Bon9EHArSU6bcCi8KdWj7w" visible="1" canBeVaried="1" />
-                      <Parameter id="n3KYen8vv0q38dV7U5mwDQ" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" visible="1" canBeVaried="1" value="10" displayUnit="cm/min" />
-                      <Transport id="6v5ZLGpIvkGxX4i1Fe9jPA" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Transport" dimension="Amount per time" formula="W_dduNdJYkuv8orgh-tyQA" sourceAmount="gbZpi5a1-EC-twcuHrfa2Q" targetAmount="JrrWuXePoECZbaojfjCbcg" />
-                    </Children>
-                  </Container>
-                  <Parameter id="T7V36iab-EGnATPXymfQXQ" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="HHdMh0ervEilhie9UEQ6KA" visible="1" canBeVaried="1" displayUnit="cm²" />
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="XCtaZ5eYvEiQKi5swBWu6Q" name="Lung_pls_ArterialBlood_pls" description="Neighborhood between Lung/Plasma and Arterial Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="HoKbo31Lg0yRHlM9oyiwmQ" secondNeighbor="qJqHlxhje0erBO7-fTj4-g">
-                <Tags>
-                  <Tag value="Neighborhood: Plasma / Plasma" />
-                </Tags>
-                <Children>
-                  <Container id="FH3NHr5m8kyKFOhOZsodrA" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Transport id="SZUHRKoPqUOrpV6baNitig" name="MassTransferOrgPl2BloodPool_Lng" description="Mass transfer from Lung: Plasma to Arterial Blood: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="AUnT1K-hCUqHuqVeH4NoJA" sourceAmount="gbZpi5a1-EC-twcuHrfa2Q" targetAmount="n0un2GZNyUWFQsjdUS5RGA" />
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="P1qPkifr30uwf079Vx7fjA" name="Lung_bc_ArterialBlood_bc" description="Neighborhood between Lung/Blood Cells and Arterial Blood/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="bR9hD2e26EiSVp_aH2gLlA" secondNeighbor="0_QXjFTwnEy8-V1CtkHsew">
-                <Tags>
-                  <Tag value="Neighborhood: BloodCells / BloodCells" />
-                </Tags>
-                <Children>
-                  <Container id="LmDkWHWRLUCxuavFWLa-rQ" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Transport id="jideJVeqNECN2ON1jFFSdw" name="MassTransferOrgRBC2BloodPool_Lng" description="Mass transfer from Lung: Blood Cells to Arterial Blood: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="Gy4BZLClQk2WqIDTRGK7LQ" sourceAmount="Al9BXU4-TkesaoCcONO8ow" targetAmount="HVsSKkWIVECLvyey2mYIPw" />
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="-D-BzPQvgkSmpGFDMAeYjQ" name="Lung_int_Lung_cell" description="Neighborhood between Lung/Interstitial and Lung/Intracellular" mode="Logical" containerType="Other" firstNeighbor="92JykqpZS0GTuPIIOzwT1A" secondNeighbor="mK6pvtoPv0-s3SurtE-G7A">
-                <Tags>
-                  <Tag value="Neighborhood: Interstitial / Intracellular" />
-                </Tags>
-                <Children>
-                  <Container id="EA0L2rQz7EezstbuCLMTww" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="UuueXzvhNk6YoOIzeZpX6w" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="BtYHf38KbE2Woag0S8zVQw" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                      <Parameter id="3Mqd41_zvUuSmLGLQFWOcA" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="Y5i-HZk9NUeoA7UKGgQIDg" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                      <Parameter id="rtz-sMdgP0SfsZXe2sAIZg" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="hKXq5MVtGkCKHD0_pgT1Kg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                      <Parameter id="FpvwfR4s7Em3NKCigFdHZA" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="p_bsa76dkkG6bsceP87FTg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                      <Parameter id="4XIhGvfuv0C9j8v8eTEavQ" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                      <Parameter id="yDH4URJdnUCx_6hHGmxURQ" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                      <Parameter id="etfpuGyyFkyPjAHhCiVxBw" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="5SQhw71znkmDuNLi71LfJQ" visible="1" canBeVaried="1" />
-                      <Parameter id="m0_BPt6PyUK7vuBDr2BmqA" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="X8aa6JXQB0-b6a-LH5_Krw" visible="0" canBeVaried="1" />
-                      <Parameter id="qmELmqjJK0SvIu3j3JlRnQ" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="waC5EOkDREWXaBlTS5iJ9Q" visible="0" canBeVaried="0" />
-                      <Transport id="PWKIxtSmx0ykNNaSqE1Fvw" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Transport" dimension="Amount per time" formula="2U4Nx1VZ7EeBQmbiPoD6vA" sourceAmount="JrrWuXePoECZbaojfjCbcg" targetAmount="UXxsrAk_FkaJLEuUOEK0eQ" />
-                    </Children>
-                  </Container>
-                  <Parameter id="e08wHxBz9kqWaPqRyJiOrw" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="u21WZXdHyk-FGea3q-Ralg" visible="1" canBeVaried="1" displayUnit="cm²" />
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="7q3W2P-zmEmqlYRjBjMhpw" name="Muscle_int_Muscle_cell" description="Neighborhood between Muscle/Interstitial and Muscle/Intracellular" mode="Logical" containerType="Other" firstNeighbor="a1qYPg4xpUGRsgFsJP-ksA" secondNeighbor="bw5p5F5Dk0muSFhqeOE0AQ">
-                <Tags>
-                  <Tag value="Neighborhood: Interstitial / Intracellular" />
-                </Tags>
-                <Children>
-                  <Container id="PUOpGFiLkEOULMbb0RVZ9A" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="aaVzFy69Kkm2jHeHQu_97A" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                      <Parameter id="6jhRtjk2sEevW4kfO4_I_Q" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="BtYHf38KbE2Woag0S8zVQw" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                      <Parameter id="TIq9_TZC_02fXRDhHt9KGw" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="Y5i-HZk9NUeoA7UKGgQIDg" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                      <Parameter id="sG6t5lVuyEiRXeuiJfGbFA" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="p_bsa76dkkG6bsceP87FTg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                      <Parameter id="PdpqAR4ZxEWIh2uARRsFLg" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                      <Parameter id="ruLREIrfbE-cP397DykPfg" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="LgsxCVX-w0qsIuX0U4HSlg" visible="1" canBeVaried="1" />
-                      <Parameter id="oAP9gVI490CmKz2JvhkgMQ" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="X8aa6JXQB0-b6a-LH5_Krw" visible="0" canBeVaried="1" />
-                      <Parameter id="pMYj_2FxN0WOyofrMdz_jw" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="hKXq5MVtGkCKHD0_pgT1Kg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                      <Parameter id="elgsMZdJdUStwCpW47lEkA" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="-2QOt9DwGUeLqbN-vpgFnw" visible="0" canBeVaried="0" />
-                      <Transport id="XFLD9ettJUiT0c6tyt06BA" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Transport" dimension="Amount per time" formula="y0NiimBy3E6bio0ExkCeyA" sourceAmount="p3qnjhvmwUO-jJ5G4Wrs5g" targetAmount="asjC6lALQEGEMpPCFGvZwA" />
-                    </Children>
-                  </Container>
-                  <Parameter id="NuavbeXKyEy0NTDTOCwNxQ" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="wCJsHd9c8EuU8pmym0uo0Q" visible="1" canBeVaried="1" displayUnit="cm²" />
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="w495R20XpEKXgCbBy9-DWA" name="Muscle_pls_Muscle_bc" description="Neighborhood between Muscle/Plasma and Muscle/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="XRLei8Ut4k69NW71TsrsFA" secondNeighbor="_qU5KwpSU0W_lpkw1fcMqg">
-                <Tags>
-                  <Tag value="Neighborhood: Plasma / BloodCells" />
-                </Tags>
-                <Children>
-                  <Container id="Q6_cFJ6OLECEHVteYHv9Gg" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Transport id="YfWLAfqLzkSSNOQW188vRA" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="YPilNuuAvEOn22na2AmPlA" sourceAmount="JbH2ysob6kW6Qm7S2hrU2g" targetAmount="27a1Npm_QEaEQOPqqma4rw" />
-                    </Children>
-                  </Container>
-                  <Parameter id="3PNYtEBQZUOuqDpm5oC7hg" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="6DikydZ00EiVs-NoKqIk6Q" visible="1" canBeVaried="1" displayUnit="cm²" />
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="Eb7fe0mdvUmBVZkqvG46aQ" name="Muscle_pls_Muscle_int" description="Neighborhood between Muscle/Plasma and Muscle/Interstitial" mode="Logical" containerType="Other" firstNeighbor="XRLei8Ut4k69NW71TsrsFA" secondNeighbor="a1qYPg4xpUGRsgFsJP-ksA">
-                <Tags>
-                  <Tag value="Neighborhood: Plasma / Interstitial" />
-                </Tags>
-                <Children>
-                  <Container id="0RU4mlvcGUqfphWADGq2Xw" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="C5mP6mo9RUeeMlfQEkj0_A" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" visible="1" canBeVaried="1" value="10" displayUnit="cm/min" />
-                      <Parameter id="l_tlYH92tUGHWZcfDxdSpA" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Bon9EHArSU6bcCi8KdWj7w" visible="1" canBeVaried="1" />
-                      <Transport id="fdD7_maFqEeXeViFCk8zqA" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Transport" dimension="Amount per time" formula="WaWpecUjd0my6WXEVrLZPg" sourceAmount="JbH2ysob6kW6Qm7S2hrU2g" targetAmount="p3qnjhvmwUO-jJ5G4Wrs5g" />
-                    </Children>
-                  </Container>
-                  <Parameter id="cnE89ozDn0qoZHhLiRLnew" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="_prtB154DEynF1Ja3O2O0g" visible="1" canBeVaried="1" displayUnit="cm²" />
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="Oy1aZ4O_C0qdlCLjHy_00g" name="Muscle_pls_VenousBlood_pls" description="Neighborhood between Muscle/Plasma and Venous Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="XRLei8Ut4k69NW71TsrsFA" secondNeighbor="J2AzZMiPQUibGWyUqz4XLA">
-                <Tags>
-                  <Tag value="Neighborhood: Plasma / Plasma" />
-                </Tags>
-                <Children>
-                  <Container id="wJaRVjpR90G00Xs3lIamPg" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Transport id="BtQCZIOQ30Gtq31rkvoogA" name="MassTransferOrgPl2BloodPool" description="Mass transfer from organ: Plasma to Venous Blood: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="foZfdkJgLUqrLTzmywqE1Q" sourceAmount="JbH2ysob6kW6Qm7S2hrU2g" targetAmount="B3lPdr5IY0uIYf2oKyowmg" />
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="R_KDn8F_GkSKvAVP690KWA" name="Muscle_bc_VenousBlood_bc" description="Neighborhood between Muscle/Blood Cells and Venous Blood/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="_qU5KwpSU0W_lpkw1fcMqg" secondNeighbor="HLhY21FI2UuJWgRMTu6RlA">
-                <Tags>
-                  <Tag value="Neighborhood: BloodCells / BloodCells" />
-                </Tags>
-                <Children>
-                  <Container id="OxdVQMRdw0OaabHjemw11g" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Transport id="7SXvph8KcUetUTBfqEZF7A" name="MassTransferOrgRBC2BloodPool" description="Mass transfer from organ: Blood Cells to Arterial Blood: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="rklLkWWbxkafPB5p5nCVBg" sourceAmount="27a1Npm_QEaEQOPqqma4rw" targetAmount="GWJuEfO1Xkqh3wAfzsLyqQ" />
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="0Zj5OKR8MkaRz-1v8v3smg" name="Pancreas_pls_Pancreas_bc" description="Neighborhood between Pancreas/Plasma and Pancreas/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="cctLJe2tcEmrG89fHAxBug" secondNeighbor="MeBFC58XdEOor4pLtkobow">
-                <Tags>
-                  <Tag value="Neighborhood: Plasma / BloodCells" />
-                </Tags>
-                <Children>
-                  <Container id="HIbkHWi0S0qXPlH05lrUZg" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Transport id="BX1ELVaO50uFdTxJkyCHYQ" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="cNugkpcupEirM29eL2sM3g" sourceAmount="5o8ad95eVkm36IzpkEUdTg" targetAmount="REWBabOvWEqf_0a-yS75TA" />
-                    </Children>
-                  </Container>
-                  <Parameter id="vmRM4XOpN0O_ORdeJzVFAg" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="yoKxcwqdf0-F9E1YSvFDug" visible="1" canBeVaried="1" displayUnit="cm²" />
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="BdN27C-2VESQ_ZtFnk0b6Q" name="Pancreas_pls_Pancreas_int" description="Neighborhood between Pancreas/Plasma and Pancreas/Interstitial" mode="Logical" containerType="Other" firstNeighbor="cctLJe2tcEmrG89fHAxBug" secondNeighbor="7rzA5jsVpEabSReHCrcXRQ">
-                <Tags>
-                  <Tag value="Neighborhood: Plasma / Interstitial" />
-                </Tags>
-                <Children>
-                  <Container id="Y_iR5_LCqka30sHQ9crmGg" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="lvItY7xqyUWggcTWMAIK9A" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Bon9EHArSU6bcCi8KdWj7w" visible="1" canBeVaried="1" />
-                      <Parameter id="oi8KwrIun0ifCgrtN0Ek0g" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" visible="1" canBeVaried="1" value="10" displayUnit="cm/min" />
-                      <Transport id="EUf3aGdCL0iOLLbrP78xgQ" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Transport" dimension="Amount per time" formula="6Av5vanvR02dPBp9u38diA" sourceAmount="5o8ad95eVkm36IzpkEUdTg" targetAmount="aJsCxm_rBEyUmMry1Ys8-A" />
-                    </Children>
-                  </Container>
-                  <Parameter id="itan83ILAU-bbt4WLg4_Lw" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="GfltgqGXFkCbrFLFwr3jOQ" visible="1" canBeVaried="1" displayUnit="cm²" />
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="XmWlKPWqHUOJT7BVf2oefw" name="Pancreas_pls_PortalVein_pls" description="Neighborhood between Pancreas/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="cctLJe2tcEmrG89fHAxBug" secondNeighbor="-zX9e5Gif0qLF9-buV_xlA">
-                <Tags>
-                  <Tag value="Neighborhood: Plasma / Plasma" />
-                </Tags>
-                <Children>
-                  <Container id="4V_FnaK-lE29kncdXW4W5g" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Transport id="ine4TqZKcEGV8rDOQ-0AKQ" name="MassTransferOrgPl2BloodPool_pve" description="Mass transfer from organ: Plasma to Portal Vein: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="Pxvw60FxjEyS5_Sj0T8NzA" sourceAmount="5o8ad95eVkm36IzpkEUdTg" targetAmount="hqBDuJ9j9Eqjy73I0KZSUA" />
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="MvOBP2iLpUOtSSDEdzSyzA" name="Pancreas_int_Pancreas_cell" description="Neighborhood between Pancreas/Interstitial and Pancreas/Intracellular" mode="Logical" containerType="Other" firstNeighbor="7rzA5jsVpEabSReHCrcXRQ" secondNeighbor="4iU46nMqvEmor7uOHn6qnA">
-                <Tags>
-                  <Tag value="Neighborhood: Interstitial / Intracellular" />
-                </Tags>
-                <Children>
-                  <Container id="ZWKltGX8vUiWAEpHgwUeSQ" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="vqsgWBK4cU6KXdxBqIAGNw" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="BtYHf38KbE2Woag0S8zVQw" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                      <Parameter id="iwaoyHnSPk2pdUYf4zUblw" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="Y5i-HZk9NUeoA7UKGgQIDg" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                      <Parameter id="BwmwJz_09kivFHPu_vkEUQ" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="hKXq5MVtGkCKHD0_pgT1Kg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                      <Parameter id="a1YBLOy1nUqd04byfpPhBg" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="p_bsa76dkkG6bsceP87FTg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                      <Parameter id="zkY5ImczkUmKXru_DY_4zg" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                      <Parameter id="sNrshl12DUKS4jkUCrfjzQ" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                      <Parameter id="FmFre2mtO0ayQwe-MBeIKA" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="pg_CNu7U2Em-fPA8g_1ROA" visible="1" canBeVaried="1" />
-                      <Parameter id="6EKJxY-ZiEmiHlfCmPOpOA" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="X8aa6JXQB0-b6a-LH5_Krw" visible="0" canBeVaried="1" />
-                      <Parameter id="ekcxh6mBvke1Uod5-nRerQ" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Jhe-K99W-0iv7V1UhuZqnA" visible="0" canBeVaried="0" />
-                      <Transport id="vh1lTAa3fk-X3-jGzr1LRA" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Transport" dimension="Amount per time" formula="Oe7oDdMgJkeUBT8vwmP0WA" sourceAmount="aJsCxm_rBEyUmMry1Ys8-A" targetAmount="3CMuUyM7XkaDQ4QllGx09Q" />
-                    </Children>
-                  </Container>
-                  <Parameter id="-_6IQwJ65U6rBUoU2xsUPw" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="zjpus8_DUUaIZGsqB9g0GA" visible="1" canBeVaried="1" displayUnit="cm²" />
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="71Ro6GoFkkychfbUsfIWIQ" name="Pancreas_bc_PortalVein_bc" description="Neighborhood between Pancreas/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="MeBFC58XdEOor4pLtkobow" secondNeighbor="V3IajphOTUWt3a2j9_LOZA">
-                <Tags>
-                  <Tag value="Neighborhood: BloodCells / BloodCells" />
-                </Tags>
-                <Children>
-                  <Container id="6PwxgIBnMEmDDJSa7Bm91A" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Transport id="1_ojdiWK0kCI_5DNHL5x1Q" name="MassTransferOrgRBC2BloodPool_Pve" description="Mass transfer from organ: Blood Cells to Portal Vein: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="rSYAN85kEk-zmTybMXhnCw" sourceAmount="REWBabOvWEqf_0a-yS75TA" targetAmount="3A4PxVITtUOpr85RBMQZlg" />
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="lrC48EzxwEiI9YN-9_WsgQ" name="Lumen_rect_Rectum_cell" description="Neighborhood between Lumen/Rectum and Mucosa/Rectum/Intracellular" mode="Logical" containerType="Other" firstNeighbor="eprwABQUEkOQApydkOYKug" secondNeighbor="xqyjpic_fU-nSEKNKkYMGw">
-                <Tags>
-                  <Tag value="Neighborhood: Rectum / Intracellular" />
-                </Tags>
-                <Children>
-                  <Container id="rHmIvIft50-7kClxKAOhkg" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="fARsqqC4Hka0TMkpI2F__w" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="xMZNhihqpEKgsl6d4EbxCw" visible="0" canBeVaried="0" />
-                      <Parameter id="GHvKNj_g9kGj2c1qqhtR7w" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="XIA8Hwb6Cka-ABuXXYcQDw" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Parameter id="e_M7DbpNo02LKEqDgm6KrA" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="bOPO_JT8sEOF6PITZSGGVg" visible="0" canBeVaried="0" />
-                      <Parameter id="i4CeXCv8qkON9-5uAYZo-Q" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="aZYSS2yfyEqUEbGBDu38yg" visible="0" canBeVaried="0" />
-                      <Parameter id="oEUmTGA0SUCamEG60qNIAw" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Dgge5YlnU02lbR1txIXNGg" visible="0" canBeVaried="0" />
-                      <Parameter id="5ENocGF7jkeKckGau1Pwgw" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="s5I7M-OHO023bLOHJj3bcg" visible="0" canBeVaried="0" />
-                      <Parameter id="5hgaulW4WkOXwq0atsp09Q" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="GpVIfp-Ack-XNmChagqotA" visible="0" canBeVaried="1" />
-                      <Parameter id="36pSUzhM0kuBmbL94HFYng" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="aWekJ2NVAECIIbxJKJ8L5g" visible="0" canBeVaried="0" />
-                      <Parameter id="_yGf9pE0NE-EzkESSOIW8g" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="WiAF34zdQ0Cn9Ni1vX1juA" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Parameter id="1NluvF7YOUugRAQPM5I-xQ" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="jmeH5OyMqUSc9qE8Binaag" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Parameter id="gnnQ6fP8nEeSBPFOh-H8TQ" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="gxoZyuApjEuzsuLtZuZWmQ" visible="0" canBeVaried="0" />
-                      <Parameter id="kHaCYZyxdEiTPlR4CVBsaw" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="MUYCMxBgqESbYoBitI72kA" visible="0" canBeVaried="0" />
-                      <Parameter id="hlFzqzy8LEi7YNCcACtROg" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="qb_xgn5bmEOWpUBl1kqmUA" visible="0" canBeVaried="0" />
-                      <Parameter id="u3P4yTLKgU-OM2KDDeEPfQ" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="0IIh6FJV0UKyrimES0f1xg" visible="0" canBeVaried="0" />
-                      <Parameter id="OtjAmhbZXEuMA067UqXTKQ" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="KQgllSQtqk2EfhX37WilDQ" visible="0" canBeVaried="0" />
-                      <Parameter id="fjOfewjcxU-s0thqlukvxQ" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="7NEiCDSKM0i6GhEpoWb-Mw" visible="0" canBeVaried="0" />
-                      <Parameter id="76RGZ5ac1ECGE4yEKQLo1g" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="3xvkxp6qK06bn4DgEtYULA" visible="0" canBeVaried="0" />
-                      <Parameter id="BUqa4v9BrUCAIAbbdS_NlQ" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="ezAHDPnckEKYf8L1jOtGfw" visible="0" canBeVaried="0" />
-                      <Parameter id="Ari5YXVNSUmZ_ofiJDmnlQ" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="2IVWcgM31UCSVl8zMDnDhw" visible="0" canBeVaried="0" />
-                      <Parameter id="CEZ1Vl8LUU6GeHOH4v9b_Q" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Iph7YhQ5KUmsZWUX2Xf2Wg" visible="0" canBeVaried="0" />
-                      <Parameter id="Rg4uGUMx9EamIKaHwidT8g" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="LcUCvhU3W0udtbpS1KVhEQ" visible="0" canBeVaried="0" />
-                      <Parameter id="8NAWIszRCkW1ErAKcd6qEg" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="qr_x2cq_Y0C6Ur-VSCP4AQ" visible="0" canBeVaried="0" />
-                      <Parameter id="xKfz73Y-T02X5GzVzz0MBg" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="NREbm1IgPECCMxntCfyWiQ" visible="0" canBeVaried="0" />
-                      <Parameter id="041vYBBpb064w75Y9UmF_g" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="vSO_MC1JA0mChxdPA-XoGw" visible="0" canBeVaried="0" />
-                      <Parameter id="Cjq4RsCn9EKs7CffoP2R7g" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="PEhoVdLppU-G3xULjX_71g" visible="0" canBeVaried="0" />
-                      <Parameter id="ZEgE6XvkFkyXvz9kV2VgrQ" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="pGvG5UNdC0Sot3_d3Qdvag" visible="0" canBeVaried="0" />
-                      <Parameter id="aE5sdkn2M02M5bD3WXNvLA" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="jJfeJ2YxEki9TK9XP6uUMA" visible="0" canBeVaried="0" />
-                      <Parameter id="fZWzShi7uU-U5IwjMl2h8Q" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DNF0kWPUFk-rtSd0Ng1Mkw" visible="0" canBeVaried="0" />
-                      <Parameter id="W3MB9dikv0yxk8Ph-yBmeg" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DNGx_vFWp0KdOb7CGcoTLQ" visible="0" canBeVaried="0" />
-                      <Transport id="fVtYZMBrz0-C_m2ustBJtg" name="DrugAbsorption_trans" description="Drug absorption transcellular" mode="Logical" containerType="Transport" dimension="Amount per time" formula="KK9g_ZIbk0ymfNqNAETXzA" sourceAmount="2kdpKYdY3EeBvJPRNS1TEg" targetAmount="QVE4GWVZMEmvb2TwJk78sQ">
-                        <Children>
-                          <Parameter id="SdrxBn9MukeNIIOr5mPQVQ" name="ProcessRate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="7IAl1PYIyU-zyu6IqQUE4g" visible="0" canBeVaried="1" displayUnit="µmol/min">
-                            <Tags>
-                              <Tag value="DrugAbsorption_trans" />
-                              <Tag value="ProcessRate" />
-                              <Tag value="C1" />
-                              <Tag value="Lumen_rect_Rectum_cell" />
-                              <Tag value="Passive" />
-                            </Tags>
-                          </Parameter>
-                        </Children>
-                      </Transport>
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="7eAyEQjlqkWL7yWbTbNZ0g" name="Rectum_pls_PortalVein_pls" description="Neighborhood between Rectum/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="WMIBikKwrEe1vMFMiv-ong" secondNeighbor="-zX9e5Gif0qLF9-buV_xlA">
-                <Tags>
-                  <Tag value="Neighborhood: Plasma / Plasma" />
-                </Tags>
-                <Children>
-                  <Container id="GOVEaFAIYU2pXtHTqtdFxg" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="j12ETevWsUynb7hjrLTTkA" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="9XHjLuJnUkqhlXb3EQzr1w" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Transport id="eltFZGqVn0CoLIRv8YPt_w" name="MassTransferMucosaToPvePlasma" description="Mass transfer from Mucosa:Plasma To Portal Vein: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="7J1UFBBLAUCHC563vmLm8w" sourceAmount="w16XRTEu1kCkEKI9PKRZEg" targetAmount="hqBDuJ9j9Eqjy73I0KZSUA" />
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="1Rw_IaS0GEKfO5CxKAdiiQ" name="Rectum_bc_PortalVein_bc" description="Neighborhood between Rectum/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="XuC4VFLrok2cYGGvu6Zk6A" secondNeighbor="V3IajphOTUWt3a2j9_LOZA">
-                <Tags>
-                  <Tag value="Neighborhood: BloodCells / BloodCells" />
-                </Tags>
-                <Children>
-                  <Container id="75ZsegOPAUSHSDpmxmsP9A" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="NLs5l8Ix_ESovVg3Ntg4eA" name="Mass transfer rate (mucosa to portal vein blood cells)" description="Mass transfer rate (mucosa to portal vein blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="UybmXii5q0qBPyZHTkgV8A" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Transport id="K3ps_KBwykCSVvJCpamMMw" name="MassTransferMucosaToPveBC" description="Mass transfer from Mucosa:Blood Cells To Portal Vein: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="Ddlo4PcB-kunD1pva3cVSw" sourceAmount="r0gwYEI_O0mcxiowmhPpKQ" targetAmount="3A4PxVITtUOpr85RBMQZlg" />
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="iAKB7DYeAEK8w2ZQqZ6bxg" name="Lumen_rect_Rectum_pls" description="Neighborhood between Lumen/Rectum and Mucosa/Rectum/Plasma" mode="Logical" containerType="Other" firstNeighbor="eprwABQUEkOQApydkOYKug" secondNeighbor="WMIBikKwrEe1vMFMiv-ong">
-                <Tags>
-                  <Tag value="Neighborhood: Rectum / Plasma" />
-                </Tags>
-                <Children>
-                  <Container id="pkVOB6zxFkue2FZE0bYgjQ" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="Cp_TQiR4WUewT7P-xYuOGw" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="ts61JbLRVk2xt3IFmtfObQ" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Parameter id="gG-N1H1Vt0OAZRaQYqfagA" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="ZjQKDR1WS0Cu5v8IvPpkyw" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Parameter id="i0HbXAafD06K1Y7pYuxHaA" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="gbcgQy55CEqF3Rb8WMyH-Q" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="cSHJspOLo06W2CHqoOLj0Q" name="PortalVein_pls_Liver_pls" description="Neighborhood between PortalVein/Plasma and Liver/Plasma" mode="Logical" containerType="Other" firstNeighbor="-zX9e5Gif0qLF9-buV_xlA" secondNeighbor="5FNaxPygXkWpARUfOC0rDA">
-                <Tags>
-                  <Tag value="Neighborhood: Plasma / Plasma" />
-                </Tags>
-                <Children>
-                  <Container id="fgwO8XBXEU6ikgDoeD-rbA" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Transport id="DgRhbwsCUk2rE_eXOe1Kdw" name="MassTransferBloodPool2OrgPl_liv" description="Mass transfer from Portal Vein: Plasma to Liver: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="Nw25zENgS0eFRhlNrAlvng" sourceAmount="hqBDuJ9j9Eqjy73I0KZSUA" targetAmount="T_cXaPk7BEyWVth9NnrBzw" />
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="f3pOhz9W-EaCgbzJk6oBLw" name="PortalVein_pls_PortalVein_bc" description="Neighborhood between PortalVein/Plasma and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="-zX9e5Gif0qLF9-buV_xlA" secondNeighbor="V3IajphOTUWt3a2j9_LOZA">
-                <Tags>
-                  <Tag value="Neighborhood: Plasma / BloodCells" />
-                </Tags>
-                <Children>
-                  <Container id="ydPpCaTIVk6HNnlhbp2CQg" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Transport id="OLDQqXg_k0C0jx_EDBsJbQ" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="830OU_D3qkC0AxHZZZBiag" sourceAmount="hqBDuJ9j9Eqjy73I0KZSUA" targetAmount="3A4PxVITtUOpr85RBMQZlg" />
-                    </Children>
-                  </Container>
-                  <Parameter id="Jho1pj_NAUqZf6Wy-_I4nQ" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="XaYmnJqT40SQfI_qEvTaGA" visible="1" canBeVaried="1" displayUnit="cm²" />
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="XApNVjUOcU63GhViSyi6kw" name="PortalVein_bc_Liver_bc" description="Neighborhood between PortalVein/Blood Cells and Liver/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="V3IajphOTUWt3a2j9_LOZA" secondNeighbor="5yZ7vQGKrEq4RZIcazhTBQ">
-                <Tags>
-                  <Tag value="Neighborhood: BloodCells / BloodCells" />
-                </Tags>
-                <Children>
-                  <Container id="QUiWA1DMUESVoepd-6Qf4w" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Transport id="vIWC7Cd30kiN86-c7IfCIw" name="MassTransferBloodPool2OrgRBC_liv" description="Mass transfer from Portal Vein: Blood Cells to Liver: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="buQ3bJBqJUiCyKdE9jZ5iQ" sourceAmount="3A4PxVITtUOpr85RBMQZlg" targetAmount="d0NG98bkQ0uyp6XKGUEC_Q" />
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="3IFTikoRrES2h_xTCaNE-A" name="Skin_pls_VenousBlood_pls" description="Neighborhood between Skin/Plasma and Venous Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="Xg7ardQtf0-u4B4xI_Q48w" secondNeighbor="J2AzZMiPQUibGWyUqz4XLA">
-                <Tags>
-                  <Tag value="Neighborhood: Plasma / Plasma" />
-                </Tags>
-                <Children>
-                  <Container id="D7m8QlvZJEi12sKMF68KEw" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Transport id="Cn2N5jo8VUqKFtT-aVOmbA" name="MassTransferOrgPl2BloodPool" description="Mass transfer from organ: Plasma to Venous Blood: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="0aSPdE9iqky2KIko-emuAQ" sourceAmount="FRvVMGhi8UOBMOTbm5lolA" targetAmount="B3lPdr5IY0uIYf2oKyowmg" />
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="4s-7CgEIukS8E6eDHq5vyg" name="Skin_pls_Skin_bc" description="Neighborhood between Skin/Plasma and Skin/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="Xg7ardQtf0-u4B4xI_Q48w" secondNeighbor="4S7otm2HZU6QSl2UbAf8-Q">
-                <Tags>
-                  <Tag value="Neighborhood: Plasma / BloodCells" />
-                </Tags>
-                <Children>
-                  <Container id="hX5sF150fkeGOLIpdVP6_w" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Transport id="D3potbfcIU6p_dT5hcuRTQ" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="KpHgtez6o0O8z8TpRJ5fZA" sourceAmount="FRvVMGhi8UOBMOTbm5lolA" targetAmount="DhjTerwdiEag5vbskJtPZw" />
-                    </Children>
-                  </Container>
-                  <Parameter id="IL7kSm8QL0aqtCS14KdNVA" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="Pwgx7i-bvkeaCbuutKJV-g" visible="1" canBeVaried="1" displayUnit="cm²" />
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="Vymu_4BZ8EmNBnIQbkhr0g" name="Skin_int_Skin_cell" description="Neighborhood between Skin/Interstitial and Skin/Intracellular" mode="Logical" containerType="Other" firstNeighbor="b8bNjxZMnEWJmwenwTXm_w" secondNeighbor="Pxv8-fk5WEym452UPM8-Tw">
-                <Tags>
-                  <Tag value="Neighborhood: Interstitial / Intracellular" />
-                </Tags>
-                <Children>
-                  <Container id="-t095YIUNUK6JQB74EP-6g" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="yNi4sF89MU29iNHX7Yh9Bg" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                      <Parameter id="y_K4_dVqpkKBRV5kQicIiw" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="KA9D0qZp6ESm0OGlCepAtA" visible="1" canBeVaried="1" />
-                      <Parameter id="EwL9ySJ55kCzWyTWwE3a9w" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="X8aa6JXQB0-b6a-LH5_Krw" visible="0" canBeVaried="1" />
-                      <Parameter id="5YEePCVbb0GyDYuxlQKB_A" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="hKXq5MVtGkCKHD0_pgT1Kg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                      <Parameter id="0qDbFywBBUWqTIFKllPRkA" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                      <Parameter id="fqi45-9NakuJs7BO2xjT1Q" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="p_bsa76dkkG6bsceP87FTg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                      <Parameter id="f-eq3eaq-kGA9403upeaMQ" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="BtYHf38KbE2Woag0S8zVQw" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                      <Parameter id="K-sW_YnCqEi_bmTks3qywg" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="Y5i-HZk9NUeoA7UKGgQIDg" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                      <Parameter id="CT90n_DEDUepb1RX3Hmnzg" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CE1nwk1uoUG0Dz3ad5-p-A" visible="0" canBeVaried="0" />
-                      <Transport id="oC_VuxEC5UmKubIr_p7gfA" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Transport" dimension="Amount per time" formula="bT45RzpYK0Ch2FkIw8NNUw" sourceAmount="YMmIlmXRvkKumHoleo8cVg" targetAmount="uLbNIRBmAU-vgjgQdeohRQ" />
-                    </Children>
-                  </Container>
-                  <Parameter id="KToaxYW-GUCRBB-DR3IfIw" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="aHT9WttymkCcQ_EXXopgRQ" visible="1" canBeVaried="1" displayUnit="cm²" />
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="rjWwTdqZGEOhQvRtHSzRMw" name="Skin_pls_Skin_int" description="Neighborhood between Skin/Plasma and Skin/Interstitial" mode="Logical" containerType="Other" firstNeighbor="Xg7ardQtf0-u4B4xI_Q48w" secondNeighbor="b8bNjxZMnEWJmwenwTXm_w">
-                <Tags>
-                  <Tag value="Neighborhood: Plasma / Interstitial" />
-                </Tags>
-                <Children>
-                  <Container id="dT5Tb1e-pUKPPp0vWYq6EA" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="7WXki_KSfUuN0LD50rOc0g" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" visible="1" canBeVaried="1" value="10" displayUnit="cm/min" />
-                      <Parameter id="vl_7HD4tFUKvjbWwlm9lkg" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Bon9EHArSU6bcCi8KdWj7w" visible="1" canBeVaried="1" />
-                      <Transport id="Z65115Ff4UmBsaA2s2iw5A" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Transport" dimension="Amount per time" formula="BNgpLNhrz0WB7mHOSWrWPA" sourceAmount="FRvVMGhi8UOBMOTbm5lolA" targetAmount="YMmIlmXRvkKumHoleo8cVg" />
-                    </Children>
-                  </Container>
-                  <Parameter id="aal8OrhigEeQgGCDqzUYRQ" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="M1mL5GdHW0W2i4shHC3aHA" visible="1" canBeVaried="1" displayUnit="cm²" />
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="NC9kuNGdvEey_a5-uV6Z3A" name="Skin_bc_VenousBlood_bc" description="Neighborhood between Skin/Blood Cells and Venous Blood/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="4S7otm2HZU6QSl2UbAf8-Q" secondNeighbor="HLhY21FI2UuJWgRMTu6RlA">
-                <Tags>
-                  <Tag value="Neighborhood: BloodCells / BloodCells" />
-                </Tags>
-                <Children>
-                  <Container id="GbO9fF7X60uAAFa_Hu_JHg" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Transport id="eYvG-RhP0kW4tbbOZ50M4A" name="MassTransferOrgRBC2BloodPool" description="Mass transfer from organ: Blood Cells to Arterial Blood: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="NmTGjYXhZUWK94jqbAlSfA" sourceAmount="DhjTerwdiEag5vbskJtPZw" targetAmount="GWJuEfO1Xkqh3wAfzsLyqQ" />
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="YwS3c9xsW0yK4mUOyB-46Q" name="Spleen_pls_PortalVein_pls" description="Neighborhood between Spleen/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="se5WEELXjEOw38dYu8tSjg" secondNeighbor="-zX9e5Gif0qLF9-buV_xlA">
-                <Tags>
-                  <Tag value="Neighborhood: Plasma / Plasma" />
-                </Tags>
-                <Children>
-                  <Container id="Lixv0DYqLkiBphZ056ubKw" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Transport id="BB7gAX2wAkKxuPxt4oV78Q" name="MassTransferOrgPl2BloodPool_pve" description="Mass transfer from organ: Plasma to Portal Vein: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="JBB1-q_fDk-dbderQ0ANKg" sourceAmount="89VKmmFVs0qTmpo4TCEX_A" targetAmount="hqBDuJ9j9Eqjy73I0KZSUA" />
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="N3sjjWlETkyfuqEp6uAhBw" name="Spleen_int_Spleen_cell" description="Neighborhood between Spleen/Interstitial and Spleen/Intracellular" mode="Logical" containerType="Other" firstNeighbor="pSAeoVT520aFL0c0CEzVjA" secondNeighbor="V9vXgr3GP0GEo1mfHzR8Lg">
-                <Tags>
-                  <Tag value="Neighborhood: Interstitial / Intracellular" />
-                </Tags>
-                <Children>
-                  <Container id="Ha1Xocf6JEygkEfj2bMtLA" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="dbIJUG3wikeREf15ga_nTg" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                      <Parameter id="W2Acd_l5lUuGH5aYRnfm3g" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="BtYHf38KbE2Woag0S8zVQw" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                      <Parameter id="lqPZahGLzkuvvLibYrBVkw" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="Y5i-HZk9NUeoA7UKGgQIDg" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                      <Parameter id="5pS3MJi_mEOpw1IXGb9lvA" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="hKXq5MVtGkCKHD0_pgT1Kg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                      <Parameter id="i5yroptLiEGD7GAwkwebsQ" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                      <Parameter id="WKSuqctTUkyK8Rvhn8bX4Q" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="kbWi1ECVpUm3aV2vTdzJEg" visible="1" canBeVaried="1" />
-                      <Parameter id="049FLWlMs0CrBdWkuA3Mbw" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="X8aa6JXQB0-b6a-LH5_Krw" visible="0" canBeVaried="1" />
-                      <Parameter id="BOHdys0rfE-WEh58ES-6Xw" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="p_bsa76dkkG6bsceP87FTg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                      <Parameter id="1T9dQSf2ikGNuiYyUpiKSg" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IL5MXjXgLk2jO2k-1hBbAw" visible="0" canBeVaried="0" />
-                      <Transport id="dM0tD7iIjUCoTiiEZMe-9Q" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Transport" dimension="Amount per time" formula="eg7LEKn1bUePg8fONNkChQ" sourceAmount="jGmdRn7IvUWvE6up89F5fA" targetAmount="uT-Gy4pavEOdkOTam6GdRw" />
-                    </Children>
-                  </Container>
-                  <Parameter id="YD0XmkKO1UeM1Uiq25lriA" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="_86hgyJcdkiPr06wyJujdg" visible="1" canBeVaried="1" displayUnit="cm²" />
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="rDeRjXJAO0mDX9f5My-VOw" name="Spleen_pls_Spleen_int" description="Neighborhood between Spleen/Plasma and Spleen/Interstitial" mode="Logical" containerType="Other" firstNeighbor="se5WEELXjEOw38dYu8tSjg" secondNeighbor="pSAeoVT520aFL0c0CEzVjA">
-                <Tags>
-                  <Tag value="Neighborhood: Plasma / Interstitial" />
-                </Tags>
-                <Children>
-                  <Container id="fGx_We3iWk-orpG4AZcOUw" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="DMM7fy-zuECmEdS-bpl6JQ" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" visible="1" canBeVaried="1" value="10" displayUnit="cm/min" />
-                      <Parameter id="5-2tdLIfnEKcHg4y0IYAYw" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Bon9EHArSU6bcCi8KdWj7w" visible="1" canBeVaried="1" />
-                      <Transport id="ssjUF3hZw0-zUZG0m3hK3A" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Transport" dimension="Amount per time" formula="kG9OTdD08E2ZTMDEUQelzg" sourceAmount="89VKmmFVs0qTmpo4TCEX_A" targetAmount="jGmdRn7IvUWvE6up89F5fA" />
-                    </Children>
-                  </Container>
-                  <Parameter id="YptupisAt0G2cw-2VOsiLA" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="uTlueDKN2EqTKC3cGgUoHQ" visible="1" canBeVaried="1" displayUnit="cm²" />
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="ijzpH6cFHUaITNYZMroQhA" name="Spleen_pls_Spleen_bc" description="Neighborhood between Spleen/Plasma and Spleen/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="se5WEELXjEOw38dYu8tSjg" secondNeighbor="ynfwPF5DH0CK-Pig1QT3GQ">
-                <Tags>
-                  <Tag value="Neighborhood: Plasma / BloodCells" />
-                </Tags>
-                <Children>
-                  <Container id="wRPkZPB6e02yjnnskuTbfg" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Transport id="3TZgmWlWVEGmqSZzFYHVWw" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="HcDh4w31fEWZxzPUwqhn1Q" sourceAmount="89VKmmFVs0qTmpo4TCEX_A" targetAmount="gFh2BN_Bg0uEOyNf12mJCg" />
-                    </Children>
-                  </Container>
-                  <Parameter id="aXo3ZU_ejEqJSrDti1IATA" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="43EB2-JS8EW0NK7Wa51Dng" visible="1" canBeVaried="1" displayUnit="cm²" />
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="RS1cd5LQREa35KLgW3hUBg" name="Spleen_bc_PortalVein_bc" description="Neighborhood between Spleen/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="ynfwPF5DH0CK-Pig1QT3GQ" secondNeighbor="V3IajphOTUWt3a2j9_LOZA">
-                <Tags>
-                  <Tag value="Neighborhood: BloodCells / BloodCells" />
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-                <Children>
-                  <Container id="NJPV2vQc-EWbXL-gVA9Eow" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Transport id="wHakoGyprUe4kXChGovswA" name="MassTransferOrgRBC2BloodPool_Pve" description="Mass transfer from organ: Blood Cells to Portal Vein: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="gmqNhP8Du06hFK8GHEpePw" sourceAmount="gFh2BN_Bg0uEOyNf12mJCg" targetAmount="3A4PxVITtUOpr85RBMQZlg" />
-                    </Children>
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-                </Children>
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-              <Neighborhood id="MyV8HsFU3UKVEOCWKQk0Lw" name="Saliva_slv_Saliva_slv" description="Neighborhood between Saliva/SalivaGland and Saliva/Saliva" mode="Logical" containerType="Other" firstNeighbor="7LsmTn-1HkqkKkKpJXQ5AQ" secondNeighbor="y9ke9SwYJka_Ch8cxFWTmw">
-                <Tags>
-                  <Tag value="Neighborhood: SalivaGland / Saliva" />
-                </Tags>
-                <Children>
-                  <Container id="mED1_FmN80S8cFrg902EFw" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="eJPJU_B1pEKqZMAvZ8jyOA" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="_tZkvkYhQkeS2qL0X6L46A" visible="1" canBeVaried="1" />
-                      <Parameter id="DAyN3REtlUW3dyVSGzodxQ" name="SalivaPlasmaRatio" description="Ratio of saliva vs. plasma concentrations" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="0ZaLB3F56E-ERGuDy2gv3g" visible="0" canBeVaried="1" />
-                      <Transport id="2GWUP4Dsz0yA-1rdokD8rw" name="PassiveDiffusionPlsToSaliva" description="Passive diffusion plasma to saliva" mode="Logical" containerType="Transport" dimension="Amount per time" formula="vnpyBxIz9EelDNjp7A9xhg" sourceAmount="3GZVTxNM8k2EaLg6W5PP7Q" targetAmount="s0odon9lsEyxtZEzSSHy_w" />
-                    </Children>
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-                </Children>
-              </Neighborhood>
-              <Neighborhood id="TOH87HV0VU64GPNPk61oGA" name="Duodenum_pls_Duodenum_bc" description="Neighborhood between Small Intestine/Mucosa/Duodenum/Plasma and Small Intestine/Mucosa/Duodenum/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="5qa_dNfzPEqENSftAboAkA" secondNeighbor="TdV1_un1aESakxFEr6GkQw">
-                <Tags>
-                  <Tag value="Neighborhood: Plasma / BloodCells" />
-                  <Tag value="Small intestine  neighborhood" />
-                </Tags>
-                <Children>
-                  <Container id="QqzH56e9C0KZLappVOtWxA" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Transport id="PGahojgWqEK877wnfRxYxA" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="UXMsfhjPN0eWUJ8dJNi9iA" sourceAmount="9U0qncgJp0GzhMN51sFuvg" targetAmount="F5meuBt0ck6H-U7fLJ-DUg" />
-                    </Children>
-                  </Container>
-                  <Parameter id="szVAwpFkukePM0YMkr_rew" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="Rqxek59BiE2CtB_Khatz4A" visible="1" canBeVaried="1" displayUnit="cm²" />
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="xThtcDu15ECRxvkoOU7WuA" name="Duodenum_pls_Duodenum_int" description="Neighborhood between Small Intestine/Mucosa/Duodenum/Plasma and Small Intestine/Mucosa/Duodenum/Interstitial" mode="Logical" containerType="Other" firstNeighbor="5qa_dNfzPEqENSftAboAkA" secondNeighbor="qdfrt7fje02lpLnQb4CGDw">
-                <Tags>
-                  <Tag value="Neighborhood: Plasma / Interstitial" />
-                  <Tag value="Small intestine  neighborhood" />
-                </Tags>
-                <Children>
-                  <Container id="LmgcxDYiFU64hSAk-mTCcg" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="Z6wE6OCuoEmvNXuySajTCw" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" visible="1" canBeVaried="1" value="10" displayUnit="cm/min" />
-                      <Parameter id="iQwrCL5TsUi6Y1Lnf0UyiQ" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Bon9EHArSU6bcCi8KdWj7w" visible="1" canBeVaried="1" />
-                      <Transport id="6EI1FxhKCU693Kjyf0d8eQ" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Transport" dimension="Amount per time" formula="5LYZACEZ90u9jtG96Qs05w" sourceAmount="9U0qncgJp0GzhMN51sFuvg" targetAmount="fg-dyqp9w0KRdVpmwPAxnw" />
-                    </Children>
-                  </Container>
-                  <Parameter id="b2sj4ujg2UOWpIQXowVFAw" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="c_uatpZrbkikdzAX_DO-7A" visible="1" canBeVaried="1" displayUnit="cm²" />
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="qEmbvAVJ50C3PwXbsZ_UIQ" name="Duodenum_int_Duodenum_cell" description="Neighborhood between Small Intestine/Mucosa/Duodenum/Interstitial and Small Intestine/Mucosa/Duodenum/Intracellular" mode="Logical" containerType="Other" firstNeighbor="qdfrt7fje02lpLnQb4CGDw" secondNeighbor="34MfH5c9wEKhN-FvYBmvow">
-                <Tags>
-                  <Tag value="Neighborhood: Interstitial / Intracellular" />
-                  <Tag value="Small intestine  neighborhood" />
-                </Tags>
-                <Children>
-                  <Container id="dvJJP84mNEqpvlW8iPyEGg" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="KLKLU279RUSJUCtfu8rmZQ" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="bJbZb-9p3kqSAc1KeNNhWw" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                      <Parameter id="LP7n_bpYkU6MCkWZgZIk3A" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                      <Parameter id="Kwdfe-MhzUWrwGY1e-PkHg" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="vgwo_xJHp0GNTPXmQzSJnQ" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                      <Parameter id="nWccLN3KS0SjQafCw-c6_w" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="p_bsa76dkkG6bsceP87FTg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                      <Parameter id="omAnIXfpyUe9tjvCNguZqg" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                      <Parameter id="4m7YDm2z40icYteMlfPB6g" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="2AQgT6fBhUa0l8Nncq2aZw" visible="1" canBeVaried="1" />
-                      <Parameter id="4NyiNPvtvE27V6kWAzcxJQ" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="X8aa6JXQB0-b6a-LH5_Krw" visible="0" canBeVaried="1" />
-                      <Parameter id="H1WJCRjn7kai9n_2c5f_EA" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="hKXq5MVtGkCKHD0_pgT1Kg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                      <Parameter id="gS3tBWjiBke5uSHnaaLb6w" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="lu4zUH9xWUeBUaDg04lGug" visible="0" canBeVaried="0" />
-                      <Transport id="bYbrVbNKkEe3nf5OkNa4wQ" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Transport" dimension="Amount per time" formula="JOyWIpfK0Ua47TxrRFmd0w" sourceAmount="fg-dyqp9w0KRdVpmwPAxnw" targetAmount="OmmrIkIo20K9O_8M3GTn6Q" />
-                    </Children>
-                  </Container>
-                  <Parameter id="E8v3L4RJ00qb8iEzTTWxhw" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="TLFuRtl7MEuoKmQ0uic8yw" visible="1" canBeVaried="1" displayUnit="cm²" />
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="irm0VqSoGk6XAJX9hSq3sw" name="UpperJejunum_int_UpperJejunum_cell" description="Neighborhood between Small Intestine/Mucosa/Upper Jejunum/Interstitial and Small Intestine/Mucosa/Upper Jejunum/Intracellular" mode="Logical" containerType="Other" firstNeighbor="MX7UE1AYnEeTRDJ1HM7CBg" secondNeighbor="V6G7I9JiAUeouIcb-9qK3g">
-                <Tags>
-                  <Tag value="Neighborhood: Interstitial / Intracellular" />
-                  <Tag value="Small intestine  neighborhood" />
-                </Tags>
-                <Children>
-                  <Container id="f7cuok_mW0WJw92BOmSsYg" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="uGHE5izeo0S9DVQH0Owcqw" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="X8aa6JXQB0-b6a-LH5_Krw" visible="0" canBeVaried="1" />
-                      <Parameter id="64XVXjtTTECLEU9JFfZJxg" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="bJbZb-9p3kqSAc1KeNNhWw" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                      <Parameter id="ff_8ufbHXkSLGEO9HGlQzg" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="vgwo_xJHp0GNTPXmQzSJnQ" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                      <Parameter id="vIST2G5fCU6zh0tkn2Y3RQ" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="hKXq5MVtGkCKHD0_pgT1Kg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                      <Parameter id="TAlHZoI0F06XRbDITJIjnA" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="p_bsa76dkkG6bsceP87FTg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                      <Parameter id="1T2wxNCjAE-OhZbcXb520g" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                      <Parameter id="9E_jy-LwREiuRPWDla9x4Q" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="af2PCPDOyEuAqR-ooIg-Rw" visible="1" canBeVaried="1" />
-                      <Parameter id="aRAzymkbrUu__X0s_D9FJA" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
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-                      <Transport id="TsbIesFXh0KLF9YrP-ZfLw" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Transport" dimension="Amount per time" formula="UwYSkIi9-02sE0Qv0EaZBA" sourceAmount="OOb7YsEfk02jfdRenZxbbA" targetAmount="zqzRvmsGnUGFDX4cd4aGFQ" />
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-                  <Parameter id="7YtudtX0mUuI6uS0hLVbeg" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="7Qj6cdr81UeapNy4Goj2oA" visible="1" canBeVaried="1" displayUnit="cm²" />
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-                <Tags>
-                  <Tag value="Neighborhood: Plasma / BloodCells" />
-                  <Tag value="Small intestine  neighborhood" />
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-                <Children>
-                  <Container id="PMYtOuzM4kukCtulNnSm-g" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Transport id="bQnMk_tZ_0mjD6GRuWnNLQ" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="G8D7Ul9z1UaVQE1zrhNysQ" sourceAmount="PMNegnlhr0CXVnvfwhXU7g" targetAmount="RgAh2V1O4EKEVX6UAhe4zQ" />
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-                  <Parameter id="yacH5ZDsd0KPULsaRxqlvg" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="N4CZhsvcP0-diepHAuhWJQ" visible="1" canBeVaried="1" displayUnit="cm²" />
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-                <Tags>
-                  <Tag value="Neighborhood: Plasma / Interstitial" />
-                  <Tag value="Small intestine  neighborhood" />
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-                <Children>
-                  <Container id="M15Mkt1Jy0CF4MBVs9FloA" name="C1" mode="Logical" containerType="Molecule">
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-                      <Parameter id="8T8ehcUKSE-axIV0v9sGBA" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" visible="1" canBeVaried="1" value="10" displayUnit="cm/min" />
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-                      <Transport id="CANGYaoXWECuSJ-cOd638g" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Transport" dimension="Amount per time" formula="jhTdCZ9uDEqoUBz-A-yo8A" sourceAmount="PMNegnlhr0CXVnvfwhXU7g" targetAmount="OOb7YsEfk02jfdRenZxbbA" />
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-                  <Parameter id="7D9yu8F_Fkmxm92q6X-Efg" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="2ETCD54MnEWiAt_tBZxaZQ" visible="1" canBeVaried="1" displayUnit="cm²" />
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-                  <Tag value="Neighborhood: Plasma / Interstitial" />
-                  <Tag value="Small intestine  neighborhood" />
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-                <Children>
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-                      <Parameter id="bC4X5htWo0GDLkC8Z6W9XQ" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Bon9EHArSU6bcCi8KdWj7w" visible="1" canBeVaried="1" />
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-                  <Parameter id="JOLW4wP4dE2ATHWvOCscIA" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="D0dxNP3T40WQxvMNzcZFMw" visible="1" canBeVaried="1" displayUnit="cm²" />
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-                <Tags>
-                  <Tag value="Neighborhood: Plasma / BloodCells" />
-                  <Tag value="Small intestine  neighborhood" />
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-                <Children>
-                  <Container id="6o_HDomZ50KMv1umFz2wdQ" name="C1" mode="Logical" containerType="Molecule">
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-                      <Transport id="g7stXvT8gkyhH9d88Egdhw" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="SLYaGJVMkUScz9Mey6PT9Q" sourceAmount="YgLswliwdkSHukAAVZwL5w" targetAmount="6Aqs6_wfI0OKiplexvNuNQ" />
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-                  <Parameter id="RGYxEyTbuE6pjOQguNBBZA" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="pHA67NumvEepJEIjTHTliQ" visible="1" canBeVaried="1" displayUnit="cm²" />
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-                <Tags>
-                  <Tag value="Neighborhood: Interstitial / Intracellular" />
-                  <Tag value="Small intestine  neighborhood" />
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-                <Children>
-                  <Container id="iNBQ3pIwtU2eOsN1PrXnGg" name="C1" mode="Logical" containerType="Molecule">
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-                      <Parameter id="0OE3i6Ek60KQhR8B-SHv1Q" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="X8aa6JXQB0-b6a-LH5_Krw" visible="0" canBeVaried="1" />
-                      <Parameter id="2dkXq1GWYUmENj5cpyX-BA" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="bJbZb-9p3kqSAc1KeNNhWw" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                      <Parameter id="sFlcHakz_E-t2xNRnvo6ZA" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="vgwo_xJHp0GNTPXmQzSJnQ" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                      <Parameter id="exqqNbA2Kkyi_okq6_JMRA" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="hKXq5MVtGkCKHD0_pgT1Kg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                      <Parameter id="2WsLmWrvu0u7Ck3qBcBqhw" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="p_bsa76dkkG6bsceP87FTg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                      <Parameter id="Q-NL7Met9USo3OlX2zYCZQ" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                      <Parameter id="mNgemKJGAkGXL0yeKlQwrQ" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DWIBx0rWmkO7szFTT9IFEw" visible="1" canBeVaried="1" />
-                      <Parameter id="kceyGSVGu06K2rV_mGQ_BA" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                      <Parameter id="4x34oKK0sE69ivIYF4TQEA" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="lu4zUH9xWUeBUaDg04lGug" visible="0" canBeVaried="0" />
-                      <Transport id="qs9Id3vvzUSzEOIgVzLdtQ" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Transport" dimension="Amount per time" formula="sw6eYXObDU62t_775fvBMw" sourceAmount="84aiMNio202GvttS4U_60A" targetAmount="K8vctNgQvkyF2UEwPTSuVQ" />
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-                  <Parameter id="eXQosF5Yz0a2KQhV7I7K3A" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="TKUHH20QQUmBuxBed8NcRQ" visible="1" canBeVaried="1" displayUnit="cm²" />
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-                <Tags>
-                  <Tag value="Neighborhood: Interstitial / Intracellular" />
-                  <Tag value="Small intestine  neighborhood" />
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-                <Children>
-                  <Container id="bHlE_iFA5ECUSd7zxpBTBw" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="xi_fEDtGdEewem0HS1l9Lg" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
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-                      <Parameter id="UNbizfOJTEiOMGftvjxM4w" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="vgwo_xJHp0GNTPXmQzSJnQ" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                      <Parameter id="-BekhbiZCUqEMNVO9VC1hw" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="hKXq5MVtGkCKHD0_pgT1Kg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                      <Parameter id="60VD445jEEGJbnJk2TaTew" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                      <Parameter id="SUneftpFCE6rj-xs9WpAHA" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="8ZTzweeChEa3PGEjlTPASw" visible="1" canBeVaried="1" />
-                      <Parameter id="wxFSmDi_PkCTJL65plj6oA" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="X8aa6JXQB0-b6a-LH5_Krw" visible="0" canBeVaried="1" />
-                      <Parameter id="pYLOq1-XMU-hVvwlEHlgvQ" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="p_bsa76dkkG6bsceP87FTg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                      <Parameter id="8q5Xdv1oIEeH-AtI0b5gVg" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="lu4zUH9xWUeBUaDg04lGug" visible="0" canBeVaried="0" />
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-                  <Parameter id="JqYia7xCTEOzZ2wwUTqSdw" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="-XzjNGt_RkeE_njKobwm2w" visible="1" canBeVaried="1" displayUnit="cm²" />
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-              <Neighborhood id="HZfDRpT7Ok24zf3srwzguA" name="UpperIleum_pls_UpperIleum_bc" description="Neighborhood between Small Intestine/Mucosa/Upper Ileum/Plasma and Small Intestine/Mucosa/Upper Ileum/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="wiKdxf5lkUaXODbbzJ_MgA" secondNeighbor="PSVoSQGqZEqHtyvSo86Uug">
-                <Tags>
-                  <Tag value="Neighborhood: Plasma / BloodCells" />
-                  <Tag value="Small intestine  neighborhood" />
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-                <Children>
-                  <Container id="bl0yzEx5_kiceWrxBe9IDA" name="C1" mode="Logical" containerType="Molecule">
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-                      <Transport id="l0S2o2bPrkqXMZ4pxuhvNA" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="zGGmoJ3qvE2S0tAYSyzLtw" sourceAmount="OH4tJOZD_USLmfI7ahxt3w" targetAmount="AmS23HbI_0aVgZpvEhgrww" />
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-                  <Parameter id="UkA2bxWS20OvI0CtT82G7g" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="wmYX_GFDVU2b_Iq_M31SPA" visible="1" canBeVaried="1" displayUnit="cm²" />
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-                <Tags>
-                  <Tag value="Neighborhood: Plasma / Interstitial" />
-                  <Tag value="Small intestine  neighborhood" />
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-                <Children>
-                  <Container id="cqF_v1D5PE-BC_h6JxOVQA" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="xJ7AVUj4G0eCiuV_5NZBTQ" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Bon9EHArSU6bcCi8KdWj7w" visible="1" canBeVaried="1" />
-                      <Parameter id="aKD5C3Yh00yDn6SkIxe1CA" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" visible="1" canBeVaried="1" value="10" displayUnit="cm/min" />
-                      <Transport id="LiK_lbB3M0qZHOmlo7IbMg" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Transport" dimension="Amount per time" formula="GGATSjF2WUiyO8SmCm1IjQ" sourceAmount="OH4tJOZD_USLmfI7ahxt3w" targetAmount="hrj09OGQBE2Gcy30ntzRWA" />
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-                  <Parameter id="ealWOUDX_kWQJLxBzFyp-Q" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="8PfprzVS1ESPT29ZsGn97A" visible="1" canBeVaried="1" displayUnit="cm²" />
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-                <Tags>
-                  <Tag value="Neighborhood: Plasma / BloodCells" />
-                  <Tag value="Small intestine  neighborhood" />
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-                <Children>
-                  <Container id="9FdlKwv_DUKnlLPWB0lQdQ" name="C1" mode="Logical" containerType="Molecule">
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-                      <Transport id="VbbV0xD5A0OeWzGitZf_0g" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="Nze3FIR2gUGcKZMxdYUBgw" sourceAmount="0cutZov5eEiqqp_uiBzdtw" targetAmount="o1HQX8-RRUmWuRf1rvmfuA" />
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-                  <Parameter id="ImquxIKTdUGA8IdERuzU9g" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="AzdVA1AlzEC6GdzzyVvFqg" visible="1" canBeVaried="1" displayUnit="cm²" />
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-                <Tags>
-                  <Tag value="Neighborhood: Interstitial / Intracellular" />
-                  <Tag value="Small intestine  neighborhood" />
-                </Tags>
-                <Children>
-                  <Container id="3V6j4YoS00GCPOwKEQeeVQ" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="ZlCpj_8SD0mc55-4nHiuEA" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                      <Parameter id="lBZjNOahPE2bs-ikqQAStg" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="bJbZb-9p3kqSAc1KeNNhWw" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                      <Parameter id="X-nzpoJ1y06P6jg1yUjaRQ" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="vgwo_xJHp0GNTPXmQzSJnQ" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                      <Parameter id="wyYWXnKGt0SnHyobbJiIeQ" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="p_bsa76dkkG6bsceP87FTg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                      <Parameter id="Aj-5zlLfrU6-k5TJJcH2fQ" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                      <Parameter id="VjPBnxCQMkqtALk4AC3IQg" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="59OGwbChQkOzbbrVodGG0g" visible="1" canBeVaried="1" />
-                      <Parameter id="04-kv9nYtEqWdIgyttW63g" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="X8aa6JXQB0-b6a-LH5_Krw" visible="0" canBeVaried="1" />
-                      <Parameter id="AcIHbgzxu0aj82ddhB-9Bw" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="hKXq5MVtGkCKHD0_pgT1Kg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                      <Parameter id="qmEUJBjKAU-1ohInhuBwqQ" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="lu4zUH9xWUeBUaDg04lGug" visible="0" canBeVaried="0" />
-                      <Transport id="QaLCFoZsFUOOHj9KHbbkVQ" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Transport" dimension="Amount per time" formula="VMdx-2DYRUaOLZhLbjxSGw" sourceAmount="RRkRhMuE70C8xM04dgNTkw" targetAmount="2dcifeUtpkujhqGqlE3Qnw" />
-                    </Children>
-                  </Container>
-                  <Parameter id="3UHn3yh8zkyHfN0krS-Ifw" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="0tOzDnLF_EaK0fNT4h6nhg" visible="1" canBeVaried="1" displayUnit="cm²" />
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="xA7sUm8Y4U2Uh8yw-Dqd2A" name="LowerIleum_pls_LowerIleum_int" description="Neighborhood between Small Intestine/Mucosa/Lower Ileum/Plasma and Small Intestine/Mucosa/Lower Ileum/Interstitial" mode="Logical" containerType="Other" firstNeighbor="rrdHQQGA002quyiJj14SNw" secondNeighbor="uqiskikve0-qI31H7jOgWg">
-                <Tags>
-                  <Tag value="Neighborhood: Plasma / Interstitial" />
-                  <Tag value="Small intestine  neighborhood" />
-                </Tags>
-                <Children>
-                  <Container id="9oLQD8wRyUeqCHYDqHru1Q" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="NQbNxr0Ob0mBjxMkBxAfnw" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Bon9EHArSU6bcCi8KdWj7w" visible="1" canBeVaried="1" />
-                      <Parameter id="_kHjAd0aZU2v78KNm03PwQ" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" visible="1" canBeVaried="1" value="10" displayUnit="cm/min" />
-                      <Transport id="lZDsRyhiBkaygtEDy8SvqQ" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Transport" dimension="Amount per time" formula="JUTH36hTGkiieegocH7dsg" sourceAmount="0cutZov5eEiqqp_uiBzdtw" targetAmount="RRkRhMuE70C8xM04dgNTkw" />
-                    </Children>
-                  </Container>
-                  <Parameter id="52FvDVt11EKLIhiXVEApmA" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="FRB1FqPXekmGqXsSXU_07Q" visible="1" canBeVaried="1" displayUnit="cm²" />
-                </Children>
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-              <Neighborhood id="BAmrgR49b0W6lPGK-c-9pw" name="Caecum_pls_Caecum_int" description="Neighborhood between Large Intestine/Mucosa/Cecum/Plasma and Large Intestine/Mucosa/Cecum/Interstitial" mode="Logical" containerType="Other" firstNeighbor="qk0qF8uZI06cnoMMMXTreA" secondNeighbor="3hhWlW8CU02dQMHm8E1PTg">
-                <Tags>
-                  <Tag value="Large intestine  neighborhood" />
-                  <Tag value="Neighborhood: Plasma / Interstitial" />
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-                <Children>
-                  <Container id="kRwz8nXr5UGnDBnE1K0N0A" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="IYvFlb4w7EShkWzRepLwgg" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" visible="1" canBeVaried="1" value="10" displayUnit="cm/min" />
-                      <Parameter id="vSgRG4MLIUaByV90OoOCcA" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Bon9EHArSU6bcCi8KdWj7w" visible="1" canBeVaried="1" />
-                      <Transport id="YzsaebzPpk2gE6NFOUItog" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Transport" dimension="Amount per time" formula="_R9FOyo460mhUVWyGg9uTQ" sourceAmount="Lpte9WeV50K2AalO8MrxAw" targetAmount="CNB35o9wBEK0VIuxxircsA" />
-                    </Children>
-                  </Container>
-                  <Parameter id="kLUdpD-f1Uq-XSMoUIBbKw" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="9pry90whNE-NcT4Ihka96g" visible="1" canBeVaried="1" displayUnit="cm²" />
-                </Children>
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-              <Neighborhood id="RMe7IjijCEqsE97prRggdA" name="Caecum_pls_Caecum_bc" description="Neighborhood between Large Intestine/Mucosa/Cecum/Plasma and Large Intestine/Mucosa/Cecum/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="qk0qF8uZI06cnoMMMXTreA" secondNeighbor="6kGZy_3g3U-NktadHdhW3Q">
-                <Tags>
-                  <Tag value="Large intestine  neighborhood" />
-                  <Tag value="Neighborhood: Plasma / BloodCells" />
-                </Tags>
-                <Children>
-                  <Container id="M4wS-DP3YE6TNSR21I_uyw" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Transport id="rORaoAijvUWLnAuAVGrJbQ" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="-sIx7AtIqkqaxq2ogBoQHg" sourceAmount="Lpte9WeV50K2AalO8MrxAw" targetAmount="05yORl8O3EeGbBTdKhAhHA" />
-                    </Children>
-                  </Container>
-                  <Parameter id="GZOSW-SBKU6bX9EtgvN4Jw" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="CPjr8bMwj0mRUJjq2mq-9w" visible="1" canBeVaried="1" displayUnit="cm²" />
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="Mb7NnXOiUEqAKDLQ2pLflw" name="Caecum_int_Caecum_cell" description="Neighborhood between Large Intestine/Mucosa/Cecum/Interstitial and Large Intestine/Mucosa/Cecum/Intracellular" mode="Logical" containerType="Other" firstNeighbor="3hhWlW8CU02dQMHm8E1PTg" secondNeighbor="t-B68_pEAUyLs_Kjh2XotQ">
-                <Tags>
-                  <Tag value="Large intestine  neighborhood" />
-                  <Tag value="Neighborhood: Interstitial / Intracellular" />
-                </Tags>
-                <Children>
-                  <Container id="wpBzQpyq5Um-f28F3RIjFg" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="ka4B9ngXiUCGefS32bvwVw" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="7GgvT6a2IkW_0KfC4Yta0Q" visible="1" canBeVaried="1" />
-                      <Parameter id="Xi_7pGkSPEqVfXtcwzgqMA" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="bJbZb-9p3kqSAc1KeNNhWw" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                      <Parameter id="6BGUC924hkaaWF1zxVnqbw" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="vgwo_xJHp0GNTPXmQzSJnQ" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                      <Parameter id="3NtKSshVsk-VLaPl9p83Eg" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="hKXq5MVtGkCKHD0_pgT1Kg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                      <Parameter id="1A-pL-3xakqTg5fkjMDxbg" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="p_bsa76dkkG6bsceP87FTg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                      <Parameter id="MsvZ-tAPPkibAzPGFE5oxA" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                      <Parameter id="t53XDrqaJkyiD4mGXMmytQ" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="X8aa6JXQB0-b6a-LH5_Krw" visible="0" canBeVaried="1" />
-                      <Parameter id="YyNRv0dcHUWGuF_1klGSZg" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                      <Parameter id="ex-o7OjFz0-RL-kpkuqtAA" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="2iaBngQgI0qH_r5qEaH-Vg" visible="0" canBeVaried="0" />
-                      <Transport id="qwsR_M1AUkyD0MDHU-epDg" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Transport" dimension="Amount per time" formula="mtPEUK_dbE6iNkWm4uEeQw" sourceAmount="CNB35o9wBEK0VIuxxircsA" targetAmount="gaxUc91cjECJ7Oyx20_0iw" />
-                    </Children>
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-                  <Parameter id="qA1720C4hEW949l4YlwV_w" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="5trqedDlfkySq7eU1B2QMQ" visible="1" canBeVaried="1" displayUnit="cm²" />
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-              <Neighborhood id="dc3XVtqg5EC7wtCpCF3DBg" name="ColonAscendens_pls_ColonAscendens_bc" description="Neighborhood between Large Intestine/Mucosa/Colon Ascendens/Plasma and Large Intestine/Mucosa/Colon Ascendens/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="Aivr7qttHUatCWB0Vus_ew" secondNeighbor="-BbZRBaQ_EGB3LiH3qZ_Ag">
-                <Tags>
-                  <Tag value="Large intestine  neighborhood" />
-                  <Tag value="Neighborhood: Plasma / BloodCells" />
-                </Tags>
-                <Children>
-                  <Container id="BtzIkpWIC0WsBNqCOkuMQg" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Transport id="CqQUSDrRVEWF4kB5FMM8pg" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="f6eHAcllekKlkrSYUWMYsA" sourceAmount="0zNjwXhGpkSaSYQZC4yzdw" targetAmount="Ls0R4hvRKki76eHKnnDq6g" />
-                    </Children>
-                  </Container>
-                  <Parameter id="W8z_HAl6ekmGBRfTciL7iA" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="VT5DQZ3NcUeHilY7GtTwaQ" visible="1" canBeVaried="1" displayUnit="cm²" />
-                </Children>
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-              <Neighborhood id="UsP9P8BNCEGO34OmVoQzWg" name="ColonAscendens_int_ColonAscendens_cell" description="Neighborhood between Large Intestine/Mucosa/Colon Ascendens/Interstitial and Large Intestine/Mucosa/Colon Ascendens/Intracellular" mode="Logical" containerType="Other" firstNeighbor="uvlcQsL-GUCowlN-t4ha-g" secondNeighbor="Qny8z-gEIUO-cU6ir0RqzA">
-                <Tags>
-                  <Tag value="Large intestine  neighborhood" />
-                  <Tag value="Neighborhood: Interstitial / Intracellular" />
-                </Tags>
-                <Children>
-                  <Container id="KD5IIujHp0mF1JHQ-9yT1Q" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="MExfM5CnTU-zcMHUGb8_uw" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="bJbZb-9p3kqSAc1KeNNhWw" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                      <Parameter id="7w1BulneH0ah2rOhRdJfGg" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="vgwo_xJHp0GNTPXmQzSJnQ" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                      <Parameter id="Ic175MrTeUmT3iYljbRsiQ" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="hKXq5MVtGkCKHD0_pgT1Kg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                      <Parameter id="8HaH9hkf-kOleRtSrLQ20g" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="p_bsa76dkkG6bsceP87FTg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                      <Parameter id="-xWEh5v9iUCe-fACUgSnLw" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                      <Parameter id="tqdIn9C5VEySOLyvSRQ2Vg" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                      <Parameter id="NgFnmnbLd0-dymzGs5fFCg" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="ClhQNwQFCUqP-su5M8WzEg" visible="1" canBeVaried="1" />
-                      <Parameter id="iSmyL3ZIHU-bndgBlKmmcA" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="X8aa6JXQB0-b6a-LH5_Krw" visible="0" canBeVaried="1" />
-                      <Parameter id="Elm9fv4C_027c7ihiUFrlQ" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="2iaBngQgI0qH_r5qEaH-Vg" visible="0" canBeVaried="0" />
-                      <Transport id="HWHBkM1xoka93OOwlWVCGQ" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Transport" dimension="Amount per time" formula="iVs-dDr7IUyF0qjJHnM7ZA" sourceAmount="9bgCoeKsLkKvhkx6FdY3iQ" targetAmount="Y5D_k9113E2RRgqowuESsw" />
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-                  </Container>
-                  <Parameter id="UAa_BsyqHkOADwLBHw4JiA" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="uiMNQfq840OK_Ycg_f_srQ" visible="1" canBeVaried="1" displayUnit="cm²" />
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-              <Neighborhood id="H3tvqEkQyEaZ5I2gfnB_Ig" name="ColonAscendens_pls_ColonAscendens_int" description="Neighborhood between Large Intestine/Mucosa/Colon Ascendens/Plasma and Large Intestine/Mucosa/Colon Ascendens/Interstitial" mode="Logical" containerType="Other" firstNeighbor="Aivr7qttHUatCWB0Vus_ew" secondNeighbor="uvlcQsL-GUCowlN-t4ha-g">
-                <Tags>
-                  <Tag value="Large intestine  neighborhood" />
-                  <Tag value="Neighborhood: Plasma / Interstitial" />
-                </Tags>
-                <Children>
-                  <Container id="gX9UFrTSXEavfWtGNosaOw" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="7qs7Q5Cmq0KhayKqpwEuoA" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" visible="1" canBeVaried="1" value="10" displayUnit="cm/min" />
-                      <Parameter id="FhBq2gwhkUWyQdaWgruToQ" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Bon9EHArSU6bcCi8KdWj7w" visible="1" canBeVaried="1" />
-                      <Transport id="ryE0_k6BL0muxWc_QPz2-A" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Transport" dimension="Amount per time" formula="rxD-LCUKQUuBOErJlbxCYQ" sourceAmount="0zNjwXhGpkSaSYQZC4yzdw" targetAmount="9bgCoeKsLkKvhkx6FdY3iQ" />
-                    </Children>
-                  </Container>
-                  <Parameter id="DIPf5pxUyU6znG5KI4JRLQ" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="MX66-yfiZEeA0Puo9AgwXg" visible="1" canBeVaried="1" displayUnit="cm²" />
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-              </Neighborhood>
-              <Neighborhood id="sb5CSfd7MEmRLCjN-_5WPg" name="ColonTransversum_int_ColonTransversum_cell" description="Neighborhood between Large Intestine/Mucosa/Colon Transversum/Interstitial and Large Intestine/Mucosa/Colon Transversum/Intracellular" mode="Logical" containerType="Other" firstNeighbor="uSnfTCjzEEKsrn-SJCCw0g" secondNeighbor="bQfRvdb_CEakRfpxkmjp1g">
-                <Tags>
-                  <Tag value="Large intestine  neighborhood" />
-                  <Tag value="Neighborhood: Interstitial / Intracellular" />
-                </Tags>
-                <Children>
-                  <Container id="Mhxy7FPr4Eyz4at_XqXZwQ" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="QF_nY5fNR0Snd4psMTj1mw" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="bJbZb-9p3kqSAc1KeNNhWw" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                      <Parameter id="dn1S8ggwpEOGRRJQNpi-yg" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="vgwo_xJHp0GNTPXmQzSJnQ" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                      <Parameter id="d4_CLHlDSUeULGvQQJhLfw" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="hKXq5MVtGkCKHD0_pgT1Kg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                      <Parameter id="VaLxaS2h30uffLLjdIp0NA" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="p_bsa76dkkG6bsceP87FTg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                      <Parameter id="d4kttql4DkCWxYBkgF-vbw" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                      <Parameter id="UGIzSjTB2UKqXnaC6frIeQ" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                      <Parameter id="_UD0EugXaUaPzydAVlaRqQ" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="J75nWmI5QUCkFTXN4HaYYg" visible="1" canBeVaried="1" />
-                      <Parameter id="kMKyusRrHEuJS2_YMpFfgg" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="X8aa6JXQB0-b6a-LH5_Krw" visible="0" canBeVaried="1" />
-                      <Parameter id="0Tzq2d7ydkCo2OUVAo0zhQ" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="2iaBngQgI0qH_r5qEaH-Vg" visible="0" canBeVaried="0" />
-                      <Transport id="L1p8pIwatUmy4Bm6sQux2g" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Transport" dimension="Amount per time" formula="v5-a-KBxhkiIHNva5Xn8yw" sourceAmount="8b6AM8coN0GCBiF054tGIw" targetAmount="H0qyxGwyUkWmeHAlvjEj4w" />
-                    </Children>
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-                  <Parameter id="BtdIGOv7FkeGX8wjx7ht9Q" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="zrSgjN6zGUipvCNXPcTmdw" visible="1" canBeVaried="1" displayUnit="cm²" />
-                </Children>
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-              <Neighborhood id="fe-t4gNlck-lgPLb4YrzTg" name="ColonTransversum_pls_ColonTransversum_bc" description="Neighborhood between Large Intestine/Mucosa/Colon Transversum/Plasma and Large Intestine/Mucosa/Colon Transversum/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="-P41WVvf4kGpY92ttsK8NQ" secondNeighbor="nK4V9tiRUUy-zjLhRo56OA">
-                <Tags>
-                  <Tag value="Large intestine  neighborhood" />
-                  <Tag value="Neighborhood: Plasma / BloodCells" />
-                </Tags>
-                <Children>
-                  <Container id="XvtstZf4VUiYXr2DtllhmQ" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Transport id="80_Gdp2J-0ysPmleWsoUFw" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="EBXbpTeky02u-j9Mj-bwZQ" sourceAmount="bnMs2biCD0u9uVZoaq3RZQ" targetAmount="2BQp7lKGjkCgjUSXvOs6QQ" />
-                    </Children>
-                  </Container>
-                  <Parameter id="T9EL0yWXTEatYx9UiKZiEQ" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="atvRRRkiq0Sbi1OjqJYtrA" visible="1" canBeVaried="1" displayUnit="cm²" />
-                </Children>
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-              <Neighborhood id="wWMM3VwRG0OFLfnvuBy1ZA" name="ColonTransversum_pls_ColonTransversum_int" description="Neighborhood between Large Intestine/Mucosa/Colon Transversum/Plasma and Large Intestine/Mucosa/Colon Transversum/Interstitial" mode="Logical" containerType="Other" firstNeighbor="-P41WVvf4kGpY92ttsK8NQ" secondNeighbor="uSnfTCjzEEKsrn-SJCCw0g">
-                <Tags>
-                  <Tag value="Large intestine  neighborhood" />
-                  <Tag value="Neighborhood: Plasma / Interstitial" />
-                </Tags>
-                <Children>
-                  <Container id="9OsSIpUsW021qtK2S-FH3A" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="vy_1NZu1P0a9Y1gIVWynYQ" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" visible="1" canBeVaried="1" value="10" displayUnit="cm/min" />
-                      <Parameter id="4l89G7Qh8kyIpI4hDAJFOg" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Bon9EHArSU6bcCi8KdWj7w" visible="1" canBeVaried="1" />
-                      <Transport id="gs6W62lFBUqYd2P7RAtyaQ" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Transport" dimension="Amount per time" formula="USghaOHBhUCTWl1nlEEmIQ" sourceAmount="bnMs2biCD0u9uVZoaq3RZQ" targetAmount="8b6AM8coN0GCBiF054tGIw" />
-                    </Children>
-                  </Container>
-                  <Parameter id="QXMntk-GHU2iXztdu09D1A" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="7ZaoSmpvWUiat7CThixiHg" visible="1" canBeVaried="1" displayUnit="cm²" />
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-              <Neighborhood id="SeSEpPiX8k-NoPbQtEuaqA" name="ColonDescendens_pls_ColonDescendens_int" description="Neighborhood between Large Intestine/Mucosa/Colon Descendens/Plasma and Large Intestine/Mucosa/Colon Descendens/Interstitial" mode="Logical" containerType="Other" firstNeighbor="IYSOBD2MW0SByEccir1gtg" secondNeighbor="YUV1KDlDvUS4N8X86jTR_w">
-                <Tags>
-                  <Tag value="Large intestine  neighborhood" />
-                  <Tag value="Neighborhood: Plasma / Interstitial" />
-                </Tags>
-                <Children>
-                  <Container id="P3IxqnFna0mqD_v6uWy2ag" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="Rkn1QOHRfUuKMz4vzH5VUA" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" visible="1" canBeVaried="1" value="10" displayUnit="cm/min" />
-                      <Parameter id="sYsR_xzCwUCKIkYUWQduqQ" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Bon9EHArSU6bcCi8KdWj7w" visible="1" canBeVaried="1" />
-                      <Transport id="66Dlc5aKIUOaRvWXQySpfQ" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Transport" dimension="Amount per time" formula="Akx04NXOx0aV-E2FNakqWw" sourceAmount="fRScY5akTkSbcR1hbKcs5Q" targetAmount="OTfVa-Dmd029ivqi8nkVCQ" />
-                    </Children>
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-                  <Parameter id="UFML_fAl3EqHeV2uUGZo1A" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="F0K0gsB_lUGKtlom-fCBBg" visible="1" canBeVaried="1" displayUnit="cm²" />
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-              <Neighborhood id="BL48pePMz0yvX7i5pP5q6g" name="ColonDescendens_pls_ColonDescendens_bc" description="Neighborhood between Large Intestine/Mucosa/Colon Descendens/Plasma and Large Intestine/Mucosa/Colon Descendens/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="IYSOBD2MW0SByEccir1gtg" secondNeighbor="0Ysv4senlEeNmmozTIAQkw">
-                <Tags>
-                  <Tag value="Large intestine  neighborhood" />
-                  <Tag value="Neighborhood: Plasma / BloodCells" />
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-                <Children>
-                  <Container id="IPo_MNDWUkO0IcapdxkAqA" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Transport id="CXGvCaD3Tk-0in0d5iF75Q" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="BqIYDin2A0qQzsIcjPd7Kw" sourceAmount="fRScY5akTkSbcR1hbKcs5Q" targetAmount="3eMVtSbfykKuZmsiS31jUg" />
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-                  <Parameter id="r_hgqFcADEGIUEvnZS9IWg" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="JMGeqBqNPkK_L8wXIgo4Kg" visible="1" canBeVaried="1" displayUnit="cm²" />
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-              <Neighborhood id="HwSKYTfqU0O8Uut94qRBRw" name="ColonDescendens_int_ColonDescendens_cell" description="Neighborhood between Large Intestine/Mucosa/Colon Descendens/Interstitial and Large Intestine/Mucosa/Colon Descendens/Intracellular" mode="Logical" containerType="Other" firstNeighbor="YUV1KDlDvUS4N8X86jTR_w" secondNeighbor="yvx9mFVur0KdwvcmwHHcQw">
-                <Tags>
-                  <Tag value="Large intestine  neighborhood" />
-                  <Tag value="Neighborhood: Interstitial / Intracellular" />
-                </Tags>
-                <Children>
-                  <Container id="J8m2edZEZEeCkWtbQ1LIMQ" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="35Cq-_uJG0iJzrlDtbj2aA" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="vgwo_xJHp0GNTPXmQzSJnQ" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                      <Parameter id="Q3htQ7JnjUyqEodK2sAnwQ" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="bJbZb-9p3kqSAc1KeNNhWw" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                      <Parameter id="bDVdPapLfk2NPqTaYyipYQ" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="hKXq5MVtGkCKHD0_pgT1Kg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                      <Parameter id="7xre57gjikmTGoNrKNLPvQ" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                      <Parameter id="pPPk4kl0Z06LSgt6tngOug" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="p_bsa76dkkG6bsceP87FTg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                      <Parameter id="mcDl7gcX006pvVU5Fdf0zA" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                      <Parameter id="aTQylJoFhE-GYP0XtIKJWQ" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="N17eBDRd7UmnoqYXzA5PVw" visible="1" canBeVaried="1" />
-                      <Parameter id="wUEBfig6OUuQKf66bmodVw" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="X8aa6JXQB0-b6a-LH5_Krw" visible="0" canBeVaried="1" />
-                      <Parameter id="s1kgDDnnokS30Di-q_LRjA" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="2iaBngQgI0qH_r5qEaH-Vg" visible="0" canBeVaried="0" />
-                      <Transport id="JXKFq1SGxUSz2I3s9I8U7Q" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Transport" dimension="Amount per time" formula="tiyKbbGO-U2XdFs0TxBmzg" sourceAmount="OTfVa-Dmd029ivqi8nkVCQ" targetAmount="XdsPQQqfnU68je9V8z203Q" />
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-                  <Parameter id="13qMYGpYZ0Kgy9wYS2Rulg" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="2dg-EovpUU6e7Z3g45MndQ" visible="1" canBeVaried="1" displayUnit="cm²" />
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-              <Neighborhood id="7_fH9poPzEGyxUoIlWgD8A" name="ColonSigmoid_pls_ColonSigmoid_int" description="Neighborhood between Large Intestine/Mucosa/Colon Sigmoid/Plasma and Large Intestine/Mucosa/Colon Sigmoid/Interstitial" mode="Logical" containerType="Other" firstNeighbor="bzYLFyk2JkmtP6F5xOz6QQ" secondNeighbor="5HpeQ-ekKkOS2la6bazFiA">
-                <Tags>
-                  <Tag value="Large intestine  neighborhood" />
-                  <Tag value="Neighborhood: Plasma / Interstitial" />
-                </Tags>
-                <Children>
-                  <Container id="150VofmSukmfnxt3-O1Pqw" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="6J5VVbSKyUqUy2b8KmTKRA" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" visible="1" canBeVaried="1" value="10" displayUnit="cm/min" />
-                      <Parameter id="CyY8N7iWG0mnzdEtEwl6WQ" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Bon9EHArSU6bcCi8KdWj7w" visible="1" canBeVaried="1" />
-                      <Transport id="-8yyLK51KkWQn0O0zCJYqQ" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Transport" dimension="Amount per time" formula="aJq-OW2VY0uHlO7fjJMZqw" sourceAmount="xTGJR_rEKE6vG1pK_dnKhA" targetAmount="EoUr17TiR061xnfZLxGy_A" />
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-                  <Parameter id="HCQCEBFxGEi_q-xCeG4Jlw" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="iE8AatseKkGicKiY4Aldqw" visible="1" canBeVaried="1" displayUnit="cm²" />
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-              <Neighborhood id="7mbX_Ps8AUWind_3-xZdBQ" name="ColonSigmoid_pls_ColonSigmoid_bc" description="Neighborhood between Large Intestine/Mucosa/Colon Sigmoid/Plasma and Large Intestine/Mucosa/Colon Sigmoid/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="bzYLFyk2JkmtP6F5xOz6QQ" secondNeighbor="96RIWxzJSUmdHw6J1qxOyw">
-                <Tags>
-                  <Tag value="Large intestine  neighborhood" />
-                  <Tag value="Neighborhood: Plasma / BloodCells" />
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-                <Children>
-                  <Container id="smYk603oqEezzxgy4fR2tQ" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Transport id="ZQYcvDbkVESqBsVfztsIYA" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="UAb3a98lPESDQjbjXUiVOg" sourceAmount="xTGJR_rEKE6vG1pK_dnKhA" targetAmount="nPc7HZ7onEeWVXA5yaAQVg" />
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-                  <Parameter id="0wKAu4hG-E29i1SWJ7c97A" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="jysOqtClxEKyvTZFL-YxEQ" visible="1" canBeVaried="1" displayUnit="cm²" />
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-                <Tags>
-                  <Tag value="Large intestine  neighborhood" />
-                  <Tag value="Neighborhood: Interstitial / Intracellular" />
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-                <Children>
-                  <Container id="CwN_1uCkvEKJwJDVIW8pXQ" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="D5vt8lQxZEqTNAcX7JJjhA" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                      <Parameter id="CH5FKC4f50qPsKe1t9IAGw" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="VFP369WwLECg-GMu1EB3iQ" visible="1" canBeVaried="1" />
-                      <Parameter id="fXVkHsjjfkqtc_nf_Xkehw" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="X8aa6JXQB0-b6a-LH5_Krw" visible="0" canBeVaried="1" />
-                      <Parameter id="KA9mFci3fkaX8f767xHlGA" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                      <Parameter id="tL0048zYt0W78tYgMGbpLw" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="p_bsa76dkkG6bsceP87FTg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                      <Parameter id="cRc9oDhv_UamG-pd9fihYA" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="hKXq5MVtGkCKHD0_pgT1Kg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                      <Parameter id="kH4fXcQNgkyUiDIbwVvY0g" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="vgwo_xJHp0GNTPXmQzSJnQ" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                      <Parameter id="DVeQYBTHd0SqF4Sa4bxN7w" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="bJbZb-9p3kqSAc1KeNNhWw" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                      <Parameter id="83kkkQ2G1Uma_tELOo-msQ" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="2iaBngQgI0qH_r5qEaH-Vg" visible="0" canBeVaried="0" />
-                      <Transport id="5G2jAak1U0CCcnrQux4Ppg" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Transport" dimension="Amount per time" formula="K4mopCtqy0CZiOurFKSr_A" sourceAmount="EoUr17TiR061xnfZLxGy_A" targetAmount="_FYwdcJVXUmHAbB3mDuZPw" />
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-                  <Parameter id="nI1ldxVJdUy70JGjkv6r9w" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="ArZGprDfO0ufFfbcioE3dQ" visible="1" canBeVaried="1" displayUnit="cm²" />
-                </Children>
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-              <Neighborhood id="ygEjO4qct0602_AeMHMb0Q" name="Rectum_pls_Rectum_int" description="Neighborhood between Large Intestine/Mucosa/Rectum/Plasma and Large Intestine/Mucosa/Rectum/Interstitial" mode="Logical" containerType="Other" firstNeighbor="WMIBikKwrEe1vMFMiv-ong" secondNeighbor="k2lXslAcv0O9A3Owj-loLg">
-                <Tags>
-                  <Tag value="Large intestine  neighborhood" />
-                  <Tag value="Neighborhood: Plasma / Interstitial" />
-                </Tags>
-                <Children>
-                  <Container id="EtiFGWwoZUyR9LNMCcwSGQ" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="M485lTxCz0e19Nx7-tIhCA" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" visible="1" canBeVaried="1" value="10" displayUnit="cm/min" />
-                      <Parameter id="Nqf4Q1zDhUKjlDf297rtng" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Bon9EHArSU6bcCi8KdWj7w" visible="1" canBeVaried="1" />
-                      <Transport id="NUN20avVr0uavbPgSy81AA" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Transport" dimension="Amount per time" formula="RR7OlCU3gkeBr7qJByV_uA" sourceAmount="w16XRTEu1kCkEKI9PKRZEg" targetAmount="znbTFUnnCk6LEJuB7ZDqlg" />
-                    </Children>
-                  </Container>
-                  <Parameter id="F-RqMKOuEU22X9a7Ot3SkA" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="DgTtTYKZXES3KoKoaxjnMw" visible="1" canBeVaried="1" displayUnit="cm²" />
-                </Children>
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-              <Neighborhood id="Kd8XoDcl0kmLZl3qes3Qig" name="Rectum_pls_Rectum_bc" description="Neighborhood between Large Intestine/Mucosa/Rectum/Plasma and Large Intestine/Mucosa/Rectum/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="WMIBikKwrEe1vMFMiv-ong" secondNeighbor="XuC4VFLrok2cYGGvu6Zk6A">
-                <Tags>
-                  <Tag value="Large intestine  neighborhood" />
-                  <Tag value="Neighborhood: Plasma / BloodCells" />
-                </Tags>
-                <Children>
-                  <Container id="Oa0UzgPffkuiEr-0z5XyAg" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Transport id="MYR-QxLcWE6KQH8rUUPBRA" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="BgDDZfIVXESTNsAk6L79uA" sourceAmount="w16XRTEu1kCkEKI9PKRZEg" targetAmount="r0gwYEI_O0mcxiowmhPpKQ" />
-                    </Children>
-                  </Container>
-                  <Parameter id="oxihobFyukmUwFXThzTzaQ" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="-ow6f5deh0G2u42wAHXCRw" visible="1" canBeVaried="1" displayUnit="cm²" />
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="huEYTUhc2U-lXMvKP7Nt5g" name="Rectum_int_Rectum_cell" description="Neighborhood between Large Intestine/Mucosa/Rectum/Interstitial and Large Intestine/Mucosa/Rectum/Intracellular" mode="Logical" containerType="Other" firstNeighbor="k2lXslAcv0O9A3Owj-loLg" secondNeighbor="xqyjpic_fU-nSEKNKkYMGw">
-                <Tags>
-                  <Tag value="Large intestine  neighborhood" />
-                  <Tag value="Neighborhood: Interstitial / Intracellular" />
-                </Tags>
-                <Children>
-                  <Container id="qK_iCZSj4EiR2CM3fxQlmQ" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="gX5qZylBEU6G51HWwDqb7w" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="X8aa6JXQB0-b6a-LH5_Krw" visible="0" canBeVaried="1" />
-                      <Parameter id="yMERbQiEH0imi-bqd36B2g" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="bJbZb-9p3kqSAc1KeNNhWw" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                      <Parameter id="d0KOPO5hVkS7PyluIPhN0g" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="vgwo_xJHp0GNTPXmQzSJnQ" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                      <Parameter id="2soScYOv3UO9ozTMtiRHFA" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="hKXq5MVtGkCKHD0_pgT1Kg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                      <Parameter id="QMFO2IwgxU-FefW9e893dQ" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="p_bsa76dkkG6bsceP87FTg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                      <Parameter id="FD766VbEAk-1phRtWVYehA" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                      <Parameter id="TVpgCtBHjEGd78twrzSWAA" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                      <Parameter id="Cggbb1f_iE2My5DDcWheRA" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="injlmJ5hdU2NasbrBe_SPg" visible="1" canBeVaried="1" />
-                      <Parameter id="9NDnoRSE3EOalq__h1wpMw" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="2iaBngQgI0qH_r5qEaH-Vg" visible="0" canBeVaried="0" />
-                      <Transport id="fWu2Wcd4UkWT-8CbwZZZZA" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Transport" dimension="Amount per time" formula="TNHBU_S6kUyj541VF4FL9g" sourceAmount="znbTFUnnCk6LEJuB7ZDqlg" targetAmount="QVE4GWVZMEmvb2TwJk78sQ" />
-                    </Children>
-                  </Container>
-                  <Parameter id="7Yl_pW-Ck0OVS4Zw1gCIpQ" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="Dhw5KfO2jUKF8MJtGG72ZA" visible="1" canBeVaried="1" displayUnit="cm²" />
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="e9XiNxmlNUq2Q993Qz-O7w" name="Caecum_bc_PortalVein_bc" description="Neighborhood between Cecum/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="6kGZy_3g3U-NktadHdhW3Q" secondNeighbor="V3IajphOTUWt3a2j9_LOZA">
-                <Tags>
-                  <Tag value="Neighborhood: BloodCells / BloodCells" />
-                </Tags>
-                <Children>
-                  <Container id="Pjq-Fqu3tECe9XGs1pTrKg" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="joS7tZ4vpECciqlL4sehyg" name="Mass transfer rate (mucosa to portal vein blood cells)" description="Mass transfer rate (mucosa to portal vein blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="hhgsXpSYWUCOcVpCJA2n1w" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Transport id="evDdCW1m50mgrtmtzpIKfg" name="MassTransferMucosaToPveBC" description="Mass transfer from Mucosa:Blood Cells To Portal Vein: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="JZvPFhHMhkKsX20YxpBGCg" sourceAmount="05yORl8O3EeGbBTdKhAhHA" targetAmount="3A4PxVITtUOpr85RBMQZlg" />
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="L-0o7OGb00ujmDg-fPhrUQ" name="Lumen_cae_Caecum_cell" description="Neighborhood between Lumen/Cecum and Mucosa/Cecum/Intracellular" mode="Logical" containerType="Other" firstNeighbor="jlQkJ9VHjEatlpKzMFmnlw" secondNeighbor="t-B68_pEAUyLs_Kjh2XotQ">
-                <Tags>
-                  <Tag value="Neighborhood: Caecum / Intracellular" />
-                </Tags>
-                <Children>
-                  <Container id="S_wbgg0RGkOdARH9E0g7og" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="tGzluZKWS0OrQlOu3jVh9g" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="aZYSS2yfyEqUEbGBDu38yg" visible="0" canBeVaried="0" />
-                      <Parameter id="4_7TRkLnk02ka2ARuuGL_w" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="Xa87YOIrCUuqk8AuzdyerQ" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Parameter id="gZaaGJa1-k6sIdPcY_5yXw" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Zyv3Gbpf6Uqt5x3loUg14Q" visible="0" canBeVaried="0" />
-                      <Parameter id="9v4Uuwh7YEaAgk2pMaRMhA" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="bOPO_JT8sEOF6PITZSGGVg" visible="0" canBeVaried="0" />
-                      <Parameter id="rUNdlzQLQE2Sl7aeKlkJNw" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="tbdwwXyasUKgZTskMkVzsg" visible="0" canBeVaried="0" />
-                      <Parameter id="k8DLoMMYkUWrhQpjDsnlsg" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="ZYTb8QL8BEuzl-aXlSJ8QA" visible="0" canBeVaried="1" />
-                      <Parameter id="u38q7wHz2kK_FT-KPSliHg" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="m0r6nKhjfESJNoS_M4-1sA" visible="0" canBeVaried="0" />
-                      <Parameter id="rVPEvBm23E6HdmQHlraXFQ" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="ixCjsTfas0-ybrfchDiQIA" visible="0" canBeVaried="0" />
-                      <Parameter id="n7cACwidoE2WBRPUQvznTg" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="UrNk3ABKbkSezSCxq8IBJg" visible="0" canBeVaried="0" />
-                      <Parameter id="JTq-mTFFyEqh3B-UKNydJA" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="0IIh6FJV0UKyrimES0f1xg" visible="0" canBeVaried="0" />
-                      <Parameter id="hJ5UkSx-9kuwYDDKqw5dvQ" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="KQgllSQtqk2EfhX37WilDQ" visible="0" canBeVaried="0" />
-                      <Parameter id="TfOH2jradkm-SBoxRg-NpQ" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="7NEiCDSKM0i6GhEpoWb-Mw" visible="0" canBeVaried="0" />
-                      <Parameter id="zB281xHy1U6R9WeofYIB5Q" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="3xvkxp6qK06bn4DgEtYULA" visible="0" canBeVaried="0" />
-                      <Parameter id="-qg4Ir2YIU279In1k71Hiw" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="ezAHDPnckEKYf8L1jOtGfw" visible="0" canBeVaried="0" />
-                      <Parameter id="FQUpsFsqqk-t7GhGRLxPyA" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="2IVWcgM31UCSVl8zMDnDhw" visible="0" canBeVaried="0" />
-                      <Parameter id="GHSvqOhO2UWysgQMM9-VaQ" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DNGx_vFWp0KdOb7CGcoTLQ" visible="0" canBeVaried="0" />
-                      <Parameter id="qD7icWL6T020rr2n8yZt_w" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="YTMjQB_2qEq6Mt6HIde1Lw" visible="0" canBeVaried="0" />
-                      <Parameter id="ei9fqBCsUke-fCC3_WsXFA" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="XxrRGXjN7k2I9-W8stVfXg" visible="0" canBeVaried="0" />
-                      <Parameter id="yYXhtWYU9k-0GM3249H4Ig" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="PEhoVdLppU-G3xULjX_71g" visible="0" canBeVaried="0" />
-                      <Parameter id="yLoqBGjMQk-J1aW87pLL2w" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="pGvG5UNdC0Sot3_d3Qdvag" visible="0" canBeVaried="0" />
-                      <Parameter id="KVT8yor4kUaFXMq_DvWBHQ" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="jJfeJ2YxEki9TK9XP6uUMA" visible="0" canBeVaried="0" />
-                      <Parameter id="xGERggM8y0in8ZBFR9ylOg" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DNF0kWPUFk-rtSd0Ng1Mkw" visible="0" canBeVaried="0" />
-                      <Parameter id="I8Tj9BJrv02LONwa77cD7Q" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="gxoZyuApjEuzsuLtZuZWmQ" visible="0" canBeVaried="0" />
-                      <Parameter id="iYfitlMh5U-EKiMFAzOyRw" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="qr_x2cq_Y0C6Ur-VSCP4AQ" visible="0" canBeVaried="0" />
-                      <Parameter id="U1zZii-AKU20vya8S7qhHg" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Iph7YhQ5KUmsZWUX2Xf2Wg" visible="0" canBeVaried="0" />
-                      <Parameter id="u1oTrIuT6kCI_eprUbfpag" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="aWekJ2NVAECIIbxJKJ8L5g" visible="0" canBeVaried="0" />
-                      <Parameter id="M89Ahojlh0SEsnq-tcAvtg" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="zomQCqlsx02oSPohqFWyVw" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Parameter id="JHcJAZPco0Cd0oX1tOkYTQ" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="1geuRzcMDU-pf7NzQveoTg" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Parameter id="Yu_aqLbxtUC48cM9xkT0Sg" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="LcUCvhU3W0udtbpS1KVhEQ" visible="0" canBeVaried="0" />
-                      <Transport id="su5DKXtVVk2DkVcdekQp1g" name="DrugAbsorption_trans" description="Drug absorption transcellular" mode="Logical" containerType="Transport" dimension="Amount per time" formula="hHSsRDxF00iHAkNvfVwgBg" sourceAmount="Qnj6YM6q_kSvSvGmWycE8g" targetAmount="gaxUc91cjECJ7Oyx20_0iw">
-                        <Children>
-                          <Parameter id="x6gjvUUXlEKrJJLxdbimPQ" name="ProcessRate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="oGTujGMePUuYmwIIcDr6JQ" visible="0" canBeVaried="1" displayUnit="µmol/min">
-                            <Tags>
-                              <Tag value="DrugAbsorption_trans" />
-                              <Tag value="ProcessRate" />
-                              <Tag value="C1" />
-                              <Tag value="Lumen_cae_Caecum_cell" />
-                              <Tag value="Passive" />
-                            </Tags>
-                          </Parameter>
-                        </Children>
-                      </Transport>
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="8ZNnyppax0KaepVKDwKSGw" name="Lumen_cae_Caecum_pls" description="Neighborhood between Lumen/Cecum and Mucosa/Cecum/Plasma" mode="Logical" containerType="Other" firstNeighbor="jlQkJ9VHjEatlpKzMFmnlw" secondNeighbor="qk0qF8uZI06cnoMMMXTreA">
-                <Tags>
-                  <Tag value="Neighborhood: Caecum / Plasma" />
-                </Tags>
-                <Children>
-                  <Container id="XDe_zZvc5Uy7QJEDJwQV2Q" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="ui6UpyC8ikuxCSezOcQA9w" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="iTPK465Nd0SSr9zsthfzeA" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Parameter id="-eiIirM1mEyhgq1n5UehUw" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="sGLOiNpXX0eybYt6a7XWww" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Parameter id="_2Vc9DjkjUS6eCED_r6cnA" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="ihXLA9rdTUy5EJFrCetUUg" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="bIRxzW_8ZkKpcEMbIl3BgA" name="Caecum_pls_PortalVein_pls" description="Neighborhood between Cecum/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="qk0qF8uZI06cnoMMMXTreA" secondNeighbor="-zX9e5Gif0qLF9-buV_xlA">
-                <Tags>
-                  <Tag value="Neighborhood: Plasma / Plasma" />
-                </Tags>
-                <Children>
-                  <Container id="ntxMBYC4O0Kc6IItXeaJzw" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="_KAKxArpkECEopA4kf0ZeA" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="UGjyRn4Vukm2-3mk_CtRyg" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Transport id="yJwSdwUzNkSwP_izYJ1r4w" name="MassTransferMucosaToPvePlasma" description="Mass transfer from Mucosa:Plasma To Portal Vein: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="3BqgU5LYzEqFODdhU-mU0A" sourceAmount="Lpte9WeV50K2AalO8MrxAw" targetAmount="hqBDuJ9j9Eqjy73I0KZSUA" />
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="ktrwKPy9NEKE7UHKUReQkg" name="Lumen_coltrans_ColonTransversum_pls" description="Neighborhood between Lumen/Colon Transversum and Mucosa/Colon Transversum/Plasma" mode="Logical" containerType="Other" firstNeighbor="uB1rpzG6qkapR36UK4VYNQ" secondNeighbor="-P41WVvf4kGpY92ttsK8NQ">
-                <Tags>
-                  <Tag value="Neighborhood: ColonTransversum / Plasma" />
-                </Tags>
-                <Children>
-                  <Container id="7a6sGh3CcUiXuWDpXp5ttg" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="rIozywtIOUG59SsbXsg9Jw" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="Pmu4zootBkKraEHhPAk7mA" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Parameter id="WOqydZJ2KUOuzkE69HwnuA" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="8a3Te4qf-kWIge_L2xb8Zg" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Parameter id="7RO3IKTjDkifnUnf6W20dg" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="4yZj3e-4bUa5flzew_2bbQ" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="ujPGcNIK0EOtf-V-bBTbVw" name="ColonAscendens_bc_PortalVein_bc" description="Neighborhood between Colon Ascendens/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="-BbZRBaQ_EGB3LiH3qZ_Ag" secondNeighbor="V3IajphOTUWt3a2j9_LOZA">
-                <Tags>
-                  <Tag value="Neighborhood: BloodCells / BloodCells" />
-                </Tags>
-                <Children>
-                  <Container id="WjGvNFioPkygrWq9ATVO4Q" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="HeLgUWorYkG19opWHFSYhQ" name="Mass transfer rate (mucosa to portal vein blood cells)" description="Mass transfer rate (mucosa to portal vein blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="3i-s2cQOQUiZIsQurtJGzg" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Transport id="baw01okR7UmNfC_jfeit3g" name="MassTransferMucosaToPveBC" description="Mass transfer from Mucosa:Blood Cells To Portal Vein: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="5kF4Qyl4Y0OhrFPtaAJPEw" sourceAmount="Ls0R4hvRKki76eHKnnDq6g" targetAmount="3A4PxVITtUOpr85RBMQZlg" />
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="30ke7hjank6shl8i9ff60g" name="ColonAscendens_pls_PortalVein_pls" description="Neighborhood between Colon Ascendens/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="Aivr7qttHUatCWB0Vus_ew" secondNeighbor="-zX9e5Gif0qLF9-buV_xlA">
-                <Tags>
-                  <Tag value="Neighborhood: Plasma / Plasma" />
-                </Tags>
-                <Children>
-                  <Container id="Rnss7hsZFUWLQY9ymwwLBg" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="tzw5DvMPYEqOoTSxEWRo6w" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="XyK-KoNd00ertUqLE2L_1g" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Transport id="JFeCzlkS3kiI1XdgwXQCrg" name="MassTransferMucosaToPvePlasma" description="Mass transfer from Mucosa:Plasma To Portal Vein: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="RxSwTzu8d0iml2iyqroR0g" sourceAmount="0zNjwXhGpkSaSYQZC4yzdw" targetAmount="hqBDuJ9j9Eqjy73I0KZSUA" />
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="A2dbFb8_P0S-DQUTIB6Evg" name="ColonSigmoid_pls_PortalVein_pls" description="Neighborhood between Colon Sigmoid/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="bzYLFyk2JkmtP6F5xOz6QQ" secondNeighbor="-zX9e5Gif0qLF9-buV_xlA">
-                <Tags>
-                  <Tag value="Neighborhood: Plasma / Plasma" />
-                </Tags>
-                <Children>
-                  <Container id="od0ecc4Z3kCkhryHHogvPg" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="WSu1uF6RLkuiAjgGu7a0SA" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="D4zn5z4QN0GXVYulMgYFSQ" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Transport id="QDYIYu8mXECNsawolb9lFA" name="MassTransferMucosaToPvePlasma" description="Mass transfer from Mucosa:Plasma To Portal Vein: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="SUC1LGiVKEe240XtHOZ1Tw" sourceAmount="xTGJR_rEKE6vG1pK_dnKhA" targetAmount="hqBDuJ9j9Eqjy73I0KZSUA" />
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="DOOesdl3-EKTF-x5Bubifw" name="Lumen_colsigm_ColonSigmoid_cell" description="Neighborhood between Lumen/Colon Sigmoid and Mucosa/Colon Sigmoid/Intracellular" mode="Logical" containerType="Other" firstNeighbor="FF0ppGi5GkaCMtFrfbD1kA" secondNeighbor="dEAYEXl0dk2Rv-tt0gU9NA">
-                <Tags>
-                  <Tag value="Neighborhood: ColonSigmoid / Intracellular" />
-                </Tags>
-                <Children>
-                  <Container id="jUSayz17YUO4LxqYlivw9A" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="ITgqeMGFhEOZNxoLmfD3bw" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="L7Hijph3_EuoO-2XIbV6JQ" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Parameter id="k_X4lIIeVUWt0HsT8KAEdw" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="0IIh6FJV0UKyrimES0f1xg" visible="0" canBeVaried="0" />
-                      <Parameter id="Dh6PZEw6zkeroh8-ZW8V5A" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="bOPO_JT8sEOF6PITZSGGVg" visible="0" canBeVaried="0" />
-                      <Parameter id="1Eapr4tRi0CjyaXCcyziuA" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="aZYSS2yfyEqUEbGBDu38yg" visible="0" canBeVaried="0" />
-                      <Parameter id="fLIpyDolO0acFqn7WPhdTA" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="-y8fbQtk8kiw0FGu1Gi7vQ" visible="0" canBeVaried="0" />
-                      <Parameter id="7d0sNBFJeEW5ECt0PcXxrw" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="c8CVAQA3aUiOambC3EzcgQ" visible="0" canBeVaried="1" />
-                      <Parameter id="8ncnF2-QJUyEhs32rs1PBA" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="wjbx6vxr-U-ys78r3dQrnA" visible="0" canBeVaried="0" />
-                      <Parameter id="ItH2deydakiD1_a_vVsL8g" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="2XKmZQVXDkG6Bl4nf-ZqiQ" visible="0" canBeVaried="0" />
-                      <Parameter id="WnrV03VHYUmaxkRHnsSoJA" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="KQgllSQtqk2EfhX37WilDQ" visible="0" canBeVaried="0" />
-                      <Parameter id="oez0ZLha_UKgnKJ5_Vy4kw" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="NJ38btrOWEa1Cg9esiHTGw" visible="0" canBeVaried="0" />
-                      <Parameter id="NSpEINPFeU68zTTIKn8T1Q" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="aWekJ2NVAECIIbxJKJ8L5g" visible="0" canBeVaried="0" />
-                      <Parameter id="8F-X-8eZ7U6nNotGAfoy4Q" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="PEhoVdLppU-G3xULjX_71g" visible="0" canBeVaried="0" />
-                      <Parameter id="K2CC8oDuWEKnuR362-Kwlg" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="7NEiCDSKM0i6GhEpoWb-Mw" visible="0" canBeVaried="0" />
-                      <Parameter id="QWuvgutxDkafPbMDTug17g" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="3xvkxp6qK06bn4DgEtYULA" visible="0" canBeVaried="0" />
-                      <Parameter id="0tlInJ4AdEexV1_7Igx-MQ" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="ezAHDPnckEKYf8L1jOtGfw" visible="0" canBeVaried="0" />
-                      <Parameter id="nuHcH8tTpk-pkf6ewKrmww" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="2IVWcgM31UCSVl8zMDnDhw" visible="0" canBeVaried="0" />
-                      <Parameter id="cw8XBrQKz0yMZsQA495ocw" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DNGx_vFWp0KdOb7CGcoTLQ" visible="0" canBeVaried="0" />
-                      <Parameter id="Oh-2yhhbV0O7hU8HIiseBA" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="LcUCvhU3W0udtbpS1KVhEQ" visible="0" canBeVaried="0" />
-                      <Parameter id="t1B_uoIa6kG7LChZ639kgg" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="YEbmKmAvpECG0bdWMocg9Q" visible="0" canBeVaried="0" />
-                      <Parameter id="xlPC5D82xUS3ybe0_ZUVkw" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="sNNMlbVUOUut2aLPW7bupg" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Parameter id="TWxn4NuXIkitN7kT-M4SXg" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="5xT4jt0-Q0ezqb7fPF0oEw" visible="0" canBeVaried="0" />
-                      <Parameter id="Iizbz-nBiUqEvGNPDVjz1Q" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="hhUrCV9ee0KZfGG1eddvuA" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Parameter id="5M8OVfgD5U2bsUOaeHP6ug" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="pGvG5UNdC0Sot3_d3Qdvag" visible="0" canBeVaried="0" />
-                      <Parameter id="V04SoDYbOk-Pl2Ks9R3MgA" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="jJfeJ2YxEki9TK9XP6uUMA" visible="0" canBeVaried="0" />
-                      <Parameter id="J5pafob0Ek6JD2uPHYG6fQ" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DNF0kWPUFk-rtSd0Ng1Mkw" visible="0" canBeVaried="0" />
-                      <Parameter id="be-tM87dhEGqRdwcyD6vZA" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="gxoZyuApjEuzsuLtZuZWmQ" visible="0" canBeVaried="0" />
-                      <Parameter id="5jfoDlozMEWL_jlVFo3Qtg" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="qr_x2cq_Y0C6Ur-VSCP4AQ" visible="0" canBeVaried="0" />
-                      <Parameter id="ykqt6rqEikmGOL1u_UdjFA" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Iph7YhQ5KUmsZWUX2Xf2Wg" visible="0" canBeVaried="0" />
-                      <Parameter id="aqPpDjIsv0Kc-_SstHYWfQ" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="FTB7kyIBw0-iNjzKVHo_Pg" visible="0" canBeVaried="0" />
-                      <Transport id="d2Y-X8LQHki0LEf2LlEVBw" name="DrugAbsorption_trans" description="Drug absorption transcellular" mode="Logical" containerType="Transport" dimension="Amount per time" formula="8amTWAImMkWDIcGgrSe_nQ" sourceAmount="jIGCgtwn-U2Oqcv2W4G-ZQ" targetAmount="_FYwdcJVXUmHAbB3mDuZPw">
-                        <Children>
-                          <Parameter id="ed8iIdclhkCrTV5IEiic4g" name="ProcessRate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="zFMA40W4K0CA7ccSyiIjEA" visible="0" canBeVaried="1" displayUnit="µmol/min">
-                            <Tags>
-                              <Tag value="DrugAbsorption_trans" />
-                              <Tag value="ProcessRate" />
-                              <Tag value="C1" />
-                              <Tag value="Lumen_colsigm_ColonSigmoid_cell" />
-                              <Tag value="Passive" />
-                            </Tags>
-                          </Parameter>
-                        </Children>
-                      </Transport>
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="VPz-hixmg0KKKTMoadfZRg" name="Lumen_colsigm_ColonSigmoid_pls" description="Neighborhood between Lumen/Colon Sigmoid and Mucosa/Colon Sigmoid/Plasma" mode="Logical" containerType="Other" firstNeighbor="FF0ppGi5GkaCMtFrfbD1kA" secondNeighbor="bzYLFyk2JkmtP6F5xOz6QQ">
-                <Tags>
-                  <Tag value="Neighborhood: ColonSigmoid / Plasma" />
-                </Tags>
-                <Children>
-                  <Container id="hyTeYLoZekO41FzXKaFodg" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="zJSWdAQ4cEWiC0phJcS11w" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="TKP9EtLErEKyBg6FVL-9DQ" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Parameter id="RNkJUhRFLkSoBm-E_a9fcg" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="Afyrej7_k06GWPcPWU3r_A" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Parameter id="5T6sVdSCVk-19RcUQzwf-A" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="58sp_GZp6kKht6J860cu_A" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="6AbSNVrP_0mlRz2gqWxngg" name="ColonDescendens_bc_PortalVein_bc" description="Neighborhood between Colon Descendens/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="0Ysv4senlEeNmmozTIAQkw" secondNeighbor="V3IajphOTUWt3a2j9_LOZA">
-                <Tags>
-                  <Tag value="Neighborhood: BloodCells / BloodCells" />
-                </Tags>
-                <Children>
-                  <Container id="dE4_a1tFhUqmpdxQF7dQ0g" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="E5hWvWWbdkKpYq6UWArCmA" name="Mass transfer rate (mucosa to portal vein blood cells)" description="Mass transfer rate (mucosa to portal vein blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="gzRFkkg6IECjxrD2ZEB09Q" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Transport id="SBiE4AErYk-RkS8iCaxelw" name="MassTransferMucosaToPveBC" description="Mass transfer from Mucosa:Blood Cells To Portal Vein: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="Z6OsX6geUEy6xwZTAY3HuA" sourceAmount="3eMVtSbfykKuZmsiS31jUg" targetAmount="3A4PxVITtUOpr85RBMQZlg" />
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="81cB7UH72E6MV9TiAQgaUw" name="ColonDescendens_pls_PortalVein_pls" description="Neighborhood between Colon Descendens/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="IYSOBD2MW0SByEccir1gtg" secondNeighbor="-zX9e5Gif0qLF9-buV_xlA">
-                <Tags>
-                  <Tag value="Neighborhood: Plasma / Plasma" />
-                </Tags>
-                <Children>
-                  <Container id="dTmxFckF80iXoeRKh9uDxQ" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="Co_Mbc7i_Eqepc7aVBT_Tg" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="GYKpdJFJsUmDzbfRpx7kug" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Transport id="prM3dT5SJUO416GYUbqdXQ" name="MassTransferMucosaToPvePlasma" description="Mass transfer from Mucosa:Plasma To Portal Vein: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="-GuPIeYx80ep4tW9YNHDBQ" sourceAmount="fRScY5akTkSbcR1hbKcs5Q" targetAmount="hqBDuJ9j9Eqjy73I0KZSUA" />
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="kK45Q70lJ0SGignU_8Tpuw" name="ColonSigmoid_bc_PortalVein_bc" description="Neighborhood between Colon Sigmoid/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="96RIWxzJSUmdHw6J1qxOyw" secondNeighbor="V3IajphOTUWt3a2j9_LOZA">
-                <Tags>
-                  <Tag value="Neighborhood: BloodCells / BloodCells" />
-                </Tags>
-                <Children>
-                  <Container id="DX_i60fyl0WZnVnqwNqBNA" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="YrsPqX5NQUua8AiEDiUW2w" name="Mass transfer rate (mucosa to portal vein blood cells)" description="Mass transfer rate (mucosa to portal vein blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="n33NJTvHaU2hKNgd9ESOkQ" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Transport id="EsZmuwafWk6WNcOjpquzcA" name="MassTransferMucosaToPveBC" description="Mass transfer from Mucosa:Blood Cells To Portal Vein: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="0XwXTyNPP0a_bRApkQOKRw" sourceAmount="nPc7HZ7onEeWVXA5yaAQVg" targetAmount="3A4PxVITtUOpr85RBMQZlg" />
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="QM8tFgEPskCDyrdj4p8-hw" name="Lumen_coldesc_ColonDescendens_cell" description="Neighborhood between Lumen/Colon Descendens and Mucosa/Colon Descendens/Intracellular" mode="Logical" containerType="Other" firstNeighbor="Tizt5eh3cUGAxWKaiYKVQw" secondNeighbor="yvx9mFVur0KdwvcmwHHcQw">
-                <Tags>
-                  <Tag value="Neighborhood: ColonDescendens / Intracellular" />
-                </Tags>
-                <Children>
-                  <Container id="2gW5NAWqREORnp6y1W3Ipg" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="UWlX8ficg0CJUVz6xHZgDQ" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="ezAHDPnckEKYf8L1jOtGfw" visible="0" canBeVaried="0" />
-                      <Parameter id="Dc945-cTbkS5rPW1jg-4dg" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DNF0kWPUFk-rtSd0Ng1Mkw" visible="0" canBeVaried="0" />
-                      <Parameter id="UDvaUaRcjk-9fDjYcMegOg" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DNGx_vFWp0KdOb7CGcoTLQ" visible="0" canBeVaried="0" />
-                      <Parameter id="PYjeH1lrX0KoLWQ2H5kcEQ" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="LcUCvhU3W0udtbpS1KVhEQ" visible="0" canBeVaried="0" />
-                      <Parameter id="Ys1bctFDQ0qFXLGGMJgaPw" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="R53cI3ctE0CW-zrWB0Y5Tg" visible="0" canBeVaried="0" />
-                      <Parameter id="XUM164GyqEaq-zCRf6i_tg" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="LfXuaYWZ1UahBGb1fJxBSQ" visible="0" canBeVaried="0" />
-                      <Parameter id="UyUw_8PMrUyXgAqAAIVyZg" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="9bUgfPj8WEaMrHjnYPcaBg" visible="0" canBeVaried="0" />
-                      <Parameter id="OHJmal0GCECgNVSh0Nps1Q" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="PEhoVdLppU-G3xULjX_71g" visible="0" canBeVaried="0" />
-                      <Parameter id="ETmhnWL7xUS_hIy6isQKXw" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="jJfeJ2YxEki9TK9XP6uUMA" visible="0" canBeVaried="0" />
-                      <Parameter id="CX0p8xxRCUiRtgPi36XOYA" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="gxoZyuApjEuzsuLtZuZWmQ" visible="0" canBeVaried="0" />
-                      <Parameter id="4tzxIRsq00ykFSYwoNeXEw" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="qr_x2cq_Y0C6Ur-VSCP4AQ" visible="0" canBeVaried="0" />
-                      <Parameter id="9cma6pqOtEiQtAlwBaUZUg" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Iph7YhQ5KUmsZWUX2Xf2Wg" visible="0" canBeVaried="0" />
-                      <Parameter id="28x_n-A8GUC_QICTHa1cHw" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="aWekJ2NVAECIIbxJKJ8L5g" visible="0" canBeVaried="0" />
-                      <Parameter id="VEklUi_GD0m5Bh_n6Z_ltw" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="_W2-NYk84UWh3cKr31DTQw" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Parameter id="h3UhljjVAUOhTP0083WkPw" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="COQouIn95UKYSvICdnNQmA" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Parameter id="PkX15zhNGEigzNofbVYgWg" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="pGvG5UNdC0Sot3_d3Qdvag" visible="0" canBeVaried="0" />
-                      <Parameter id="2mYWlp1bKUi3V6ye8_D1yQ" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="3xvkxp6qK06bn4DgEtYULA" visible="0" canBeVaried="0" />
-                      <Parameter id="i8ejol6tn06h3IDu10KO3A" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="2IVWcgM31UCSVl8zMDnDhw" visible="0" canBeVaried="0" />
-                      <Parameter id="uvw_xlE-CUGk_DqjzOPbjw" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="TConzFPRRE-3YlGeZ4Sudg" visible="0" canBeVaried="0" />
-                      <Parameter id="ombFMbZl0EerOBbBbRAyYw" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="LAOanapz002r38qtCs8g3g" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Parameter id="9EYMvVQ41kyGYtJsWwYoZA" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="aZYSS2yfyEqUEbGBDu38yg" visible="0" canBeVaried="0" />
-                      <Parameter id="OqwDgCMRdkKFWb9oWbQA3w" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="icGT77WyRUuSy8KyZ57XtQ" visible="0" canBeVaried="1" />
-                      <Parameter id="ocoJLfvvNE2RmbiOB6rJnw" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="xl4warxR5k26wJSA_PhxAA" visible="0" canBeVaried="0" />
-                      <Parameter id="PqY8nXKtf064yek1Gxw6ug" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="cZeWSD5UJU-0eLNPLhWvpA" visible="0" canBeVaried="0" />
-                      <Parameter id="CejUz20G60GKtJP1zo8DAg" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="wD7dDxtIVUiJCaDGH_rGzQ" visible="0" canBeVaried="0" />
-                      <Parameter id="_f_mikUYl0Gm2PlDYGeDSA" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="0IIh6FJV0UKyrimES0f1xg" visible="0" canBeVaried="0" />
-                      <Parameter id="roE8Nos260SrwwTYF1nkCQ" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="KQgllSQtqk2EfhX37WilDQ" visible="0" canBeVaried="0" />
-                      <Parameter id="a4W3L_2c2UCH-TbTu0bN1w" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="7NEiCDSKM0i6GhEpoWb-Mw" visible="0" canBeVaried="0" />
-                      <Parameter id="DoqjmScJe0yFu4Qt5jBxlA" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="bOPO_JT8sEOF6PITZSGGVg" visible="0" canBeVaried="0" />
-                      <Transport id="xZWk9gkva02WU5MZh6MNLw" name="DrugAbsorption_trans" description="Drug absorption transcellular" mode="Logical" containerType="Transport" dimension="Amount per time" formula="BD1dAJKp_UCxfvnyI8QAIg" sourceAmount="yiZ323gtz0WRt_37u8tDPQ" targetAmount="XdsPQQqfnU68je9V8z203Q">
-                        <Children>
-                          <Parameter id="jqzXV6HY1UWSJaXn7rBuBA" name="ProcessRate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="7IpAKD39TUy2KNbEjwcTyg" visible="0" canBeVaried="1" displayUnit="µmol/min">
-                            <Tags>
-                              <Tag value="DrugAbsorption_trans" />
-                              <Tag value="ProcessRate" />
-                              <Tag value="C1" />
-                              <Tag value="Lumen_coldesc_ColonDescendens_cell" />
-                              <Tag value="Passive" />
-                            </Tags>
-                          </Parameter>
-                        </Children>
-                      </Transport>
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="8f97m3NM4kqXWb7RwSBOUg" name="Lumen_coldesc_ColonDescendens_pls" description="Neighborhood between Lumen/Colon Descendens and Mucosa/Colon Descendens/Plasma" mode="Logical" containerType="Other" firstNeighbor="Tizt5eh3cUGAxWKaiYKVQw" secondNeighbor="IYSOBD2MW0SByEccir1gtg">
-                <Tags>
-                  <Tag value="Neighborhood: ColonDescendens / Plasma" />
-                </Tags>
-                <Children>
-                  <Container id="Oabi5Uv4yEywb6jtcDISYQ" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="nkDbXr-XWUmgv7uysc8PpA" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="4iUYvXDlqEacAxGkAqC67w" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Parameter id="GMfNmCGdQkuBWKgOP-4XCg" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="YID9qeSfWkydTVAW3WuaOg" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Parameter id="maJTZfliq0adluLC0dd-FQ" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="2auV62OhwEKmuzNhp-oxqQ" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="bFmCYpyht06YSWiPbjEltA" name="ColonTransversum_bc_PortalVein_bc" description="Neighborhood between Colon Transversum/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="nK4V9tiRUUy-zjLhRo56OA" secondNeighbor="V3IajphOTUWt3a2j9_LOZA">
-                <Tags>
-                  <Tag value="Neighborhood: BloodCells / BloodCells" />
-                </Tags>
-                <Children>
-                  <Container id="nTMJsEsum02hjud8Vcgq-A" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="WOu2eLBpSEOyCqyJb8fk0A" name="Mass transfer rate (mucosa to portal vein blood cells)" description="Mass transfer rate (mucosa to portal vein blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="4RexIDSOV0OT0CIEJ-8DyA" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Transport id="ZzNJsUEjFEipB-9QU484ZQ" name="MassTransferMucosaToPveBC" description="Mass transfer from Mucosa:Blood Cells To Portal Vein: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="BizocUffukWBg7MqtXcfPw" sourceAmount="2BQp7lKGjkCgjUSXvOs6QQ" targetAmount="3A4PxVITtUOpr85RBMQZlg" />
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="4SnuuCYaFUqjVDubpE6arw" name="ColonTransversum_pls_PortalVein_pls" description="Neighborhood between Colon Transversum/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="-P41WVvf4kGpY92ttsK8NQ" secondNeighbor="-zX9e5Gif0qLF9-buV_xlA">
-                <Tags>
-                  <Tag value="Neighborhood: Plasma / Plasma" />
-                </Tags>
-                <Children>
-                  <Container id="7eh8xvm7IUiDXWeNh_92tQ" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="GmiZaAuWkUa1DAcZhMnTiA" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="QY_8WMM6H0SRblh5p3m8FQ" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Transport id="_ty3O4XMsUG9f0s3JrLT7w" name="MassTransferMucosaToPvePlasma" description="Mass transfer from Mucosa:Plasma To Portal Vein: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="HWTCMuZGXUenFIHk2eMV7A" sourceAmount="bnMs2biCD0u9uVZoaq3RZQ" targetAmount="hqBDuJ9j9Eqjy73I0KZSUA" />
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="PAtG_V9NNkCotrE3nlnmAA" name="Lumen_coltrans_ColonTransversum_cell" description="Neighborhood between Lumen/Colon Transversum and Mucosa/Colon Transversum/Intracellular" mode="Logical" containerType="Other" firstNeighbor="uB1rpzG6qkapR36UK4VYNQ" secondNeighbor="bQfRvdb_CEakRfpxkmjp1g">
-                <Tags>
-                  <Tag value="Neighborhood: ColonTransversum / Intracellular" />
-                </Tags>
-                <Children>
-                  <Container id="Uk8DJkB-AUix4Jc96wvFrQ" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="We2t05Mhv0em3SbW_JnRuQ" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="jb4Z8A0Z1kif3SUqv2N2pw" visible="0" canBeVaried="0" />
-                      <Parameter id="6_SrTUJ6aUmZO2EGO-tThg" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="4Zml2j67nEmYONQia7MxTQ" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Parameter id="_uYfmx9v3UKKAMkHhNtAOA" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="bOPO_JT8sEOF6PITZSGGVg" visible="0" canBeVaried="0" />
-                      <Parameter id="x9QEyvCw_k-6tmf5660L0Q" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="aZYSS2yfyEqUEbGBDu38yg" visible="0" canBeVaried="0" />
-                      <Parameter id="Pcfa__MchUetzQoIj1mpiw" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="eq49nAmg3kSap3xstrHVQw" visible="0" canBeVaried="0" />
-                      <Parameter id="cZ4mXdNJaUGagLd6NlmVGA" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DNGx_vFWp0KdOb7CGcoTLQ" visible="0" canBeVaried="0" />
-                      <Parameter id="HwNIv4sofkmJgLDhpBM2nQ" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="2rz940Tfm0mkCHYo05Rz3Q" visible="0" canBeVaried="0" />
-                      <Parameter id="JMJi-xXLrUiNHAAetAaWPA" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="XauSM7UQukeTY7249KcMmw" visible="0" canBeVaried="0" />
-                      <Parameter id="NWLYY7jEV0Kx_TygLCsw3Q" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="0IIh6FJV0UKyrimES0f1xg" visible="0" canBeVaried="0" />
-                      <Parameter id="4NgddAgeeUyjYhvMf8JrIA" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="KQgllSQtqk2EfhX37WilDQ" visible="0" canBeVaried="0" />
-                      <Parameter id="LnKqJBWS6k6gqyz3Iq8wZw" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="7NEiCDSKM0i6GhEpoWb-Mw" visible="0" canBeVaried="0" />
-                      <Parameter id="pYVwcrK_50WC5Atsv1NvaA" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="3xvkxp6qK06bn4DgEtYULA" visible="0" canBeVaried="0" />
-                      <Parameter id="BB5ywbOzqkems6502-NHeg" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="ezAHDPnckEKYf8L1jOtGfw" visible="0" canBeVaried="0" />
-                      <Parameter id="jeZwgx5TxUSAKd0QJGkIKQ" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="j2UikfOtLkeEX74qoHnjaQ" visible="0" canBeVaried="1" />
-                      <Parameter id="WOnTozo7A0m5MDHh6pdwHw" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="LcUCvhU3W0udtbpS1KVhEQ" visible="0" canBeVaried="0" />
-                      <Parameter id="nY4uJPRu8UqtIBp6fi6OtQ" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="2IVWcgM31UCSVl8zMDnDhw" visible="0" canBeVaried="0" />
-                      <Parameter id="KuvPKZuqhkaTKpG23vjIQw" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Iph7YhQ5KUmsZWUX2Xf2Wg" visible="0" canBeVaried="0" />
-                      <Parameter id="08QPDzdpKkm8gJzmmsGERw" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="ud6Lho1In0CC7LTjESlRBg" visible="0" canBeVaried="0" />
-                      <Parameter id="-j8WKX9Wmku6YWbu_nqc2A" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="uhfSXqrQvUaPieYEr-qFtg" visible="0" canBeVaried="0" />
-                      <Parameter id="0sOD5CisMkKI1oO54OC90A" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="x3x4kOtnrECym84BGneZ3g" visible="0" canBeVaried="0" />
-                      <Parameter id="9oe2NFxA-E2esQPwmP82gg" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="PEhoVdLppU-G3xULjX_71g" visible="0" canBeVaried="0" />
-                      <Parameter id="TmXKX7OanUyluU24KeLlmQ" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="pGvG5UNdC0Sot3_d3Qdvag" visible="0" canBeVaried="0" />
-                      <Parameter id="8XB72tzLTEuwUemtf-XbJA" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="jJfeJ2YxEki9TK9XP6uUMA" visible="0" canBeVaried="0" />
-                      <Parameter id="IvkTPV1AN0e3kibG9jEGcw" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DNF0kWPUFk-rtSd0Ng1Mkw" visible="0" canBeVaried="0" />
-                      <Parameter id="8XL5KZztHkuilqGP1PtJcg" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="qr_x2cq_Y0C6Ur-VSCP4AQ" visible="0" canBeVaried="0" />
-                      <Parameter id="45f2TCm4rUWLJ80A2YWdOA" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="aWekJ2NVAECIIbxJKJ8L5g" visible="0" canBeVaried="0" />
-                      <Parameter id="_A5snORjlUCvg23xM3uTjA" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="-5tSttqPf02ASx8lRUcZqg" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Parameter id="o7Z1S00JhUGM7EqBoqUcfQ" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="3Hd5PrbDhEiGMU-6VIhkXA" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Parameter id="Znsp_iZTxEWlDBfZpc0E-A" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="gxoZyuApjEuzsuLtZuZWmQ" visible="0" canBeVaried="0" />
-                      <Transport id="vKdrzgdDf0CfyWzRQSbaTA" name="DrugAbsorption_trans" description="Drug absorption transcellular" mode="Logical" containerType="Transport" dimension="Amount per time" formula="NGMIraI3JUOZIGd3dKfoPw" sourceAmount="B3i4ajvEPkWwF-QJhPT-RA" targetAmount="H0qyxGwyUkWmeHAlvjEj4w">
-                        <Children>
-                          <Parameter id="ayIGRBDmXEOiu_ccvWrqMQ" name="ProcessRate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="g9tFz37ZDkeADbvOroeIzA" visible="0" canBeVaried="1" displayUnit="µmol/min">
-                            <Tags>
-                              <Tag value="DrugAbsorption_trans" />
-                              <Tag value="ProcessRate" />
-                              <Tag value="C1" />
-                              <Tag value="Lumen_coltrans_ColonTransversum_cell" />
-                              <Tag value="Passive" />
-                            </Tags>
-                          </Parameter>
-                        </Children>
-                      </Transport>
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="LjWB6rytgUeDEqVpGfm4Ag" name="Lumen_colasc_ColonAscendens_cell" description="Neighborhood between Lumen/Colon Ascendens and Mucosa/Colon Ascendens/Intracellular" mode="Logical" containerType="Other" firstNeighbor="jhPiKsemqE2D9wuuFrqxsw" secondNeighbor="Qny8z-gEIUO-cU6ir0RqzA">
-                <Tags>
-                  <Tag value="Neighborhood: ColonAscendens / Intracellular" />
-                </Tags>
-                <Children>
-                  <Container id="5LZuKZzq3Ea-HLdPpwIijg" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="Sv7u99rmZkuJC_P1G4_FmQ" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="rdiuY1t87kuwKt5MEpldDQ" visible="0" canBeVaried="0" />
-                      <Parameter id="YSwuysr0A0a_n2LdCgRLlA" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="HrDbqzU3BkmyZxzHkLbLJA" visible="0" canBeVaried="0" />
-                      <Parameter id="Bb1toNe9D0O6VSxPBjYUzQ" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="CMygyw7Ycka3VMl5OVtYVA" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Parameter id="e3Xyxb3kF06ZEEtlvTZ-OQ" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="bOPO_JT8sEOF6PITZSGGVg" visible="0" canBeVaried="0" />
-                      <Parameter id="KWSLw_-rS02cEYntlZd4ww" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="aZYSS2yfyEqUEbGBDu38yg" visible="0" canBeVaried="0" />
-                      <Parameter id="b4yF3Cyon0mHG6sjs1eWvQ" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="1aK-WkQilEaQvWIqoRanaA" visible="0" canBeVaried="1" />
-                      <Parameter id="mT1nj0ZvS061thSiSawvJA" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="JX-VumX3fkSs2rGi3gM1MQ" visible="0" canBeVaried="0" />
-                      <Parameter id="vsni4_rZRkWXgxliiDBuYQ" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="WNRN_yyuhEqEacw7RfnGAw" visible="0" canBeVaried="0" />
-                      <Parameter id="W8ZPEvzn702hCQiRO0syeA" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="0IIh6FJV0UKyrimES0f1xg" visible="0" canBeVaried="0" />
-                      <Parameter id="DSsbgEqPA0CO8tF0ZuNPtw" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="KQgllSQtqk2EfhX37WilDQ" visible="0" canBeVaried="0" />
-                      <Parameter id="PqKKe3FIXEOFA6UGcmwBZg" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="7NEiCDSKM0i6GhEpoWb-Mw" visible="0" canBeVaried="0" />
-                      <Parameter id="_ssAkN9njESxeVd8G-c5ew" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="3xvkxp6qK06bn4DgEtYULA" visible="0" canBeVaried="0" />
-                      <Parameter id="5o0ITePF-Umpz7z6Wk2ETw" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="ezAHDPnckEKYf8L1jOtGfw" visible="0" canBeVaried="0" />
-                      <Parameter id="gKS2vC82zUOI_7z7Rlhifg" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="2IVWcgM31UCSVl8zMDnDhw" visible="0" canBeVaried="0" />
-                      <Parameter id="2dYNeTHmQUyIDnquF8XPaA" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DNGx_vFWp0KdOb7CGcoTLQ" visible="0" canBeVaried="0" />
-                      <Parameter id="WLa2NgMHcEybXTdrlbxveg" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="LcUCvhU3W0udtbpS1KVhEQ" visible="0" canBeVaried="0" />
-                      <Parameter id="w3-jtY2OfkyGl6IJ0ssyIg" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="-NEfNAk5BkeqsSm89zu2ig" visible="0" canBeVaried="0" />
-                      <Parameter id="-lWnnE1lXEuQTjXkLWTEow" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="WDU5b6PS4UuzuG7tIVBEdA" visible="0" canBeVaried="0" />
-                      <Parameter id="pnWMC5ZgvkSHtJqV3AdByA" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="bcFrf7s2kEOkv3-JRiwp1Q" visible="0" canBeVaried="0" />
-                      <Parameter id="b0QsMS1FdUWg4fUdb5Oxfw" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="rYpN5XvH2ECr2TrP9oYtiA" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Parameter id="eTZr6ThftU6t0tM7kdOWag" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="PEhoVdLppU-G3xULjX_71g" visible="0" canBeVaried="0" />
-                      <Parameter id="8EZnMTOkoUSp_lm_iskBdQ" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="pGvG5UNdC0Sot3_d3Qdvag" visible="0" canBeVaried="0" />
-                      <Parameter id="SkQ9yaHvUECW3427Si3Caw" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="jJfeJ2YxEki9TK9XP6uUMA" visible="0" canBeVaried="0" />
-                      <Parameter id="-BEAIQtafkOmLHyMMGvpuQ" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DNF0kWPUFk-rtSd0Ng1Mkw" visible="0" canBeVaried="0" />
-                      <Parameter id="Jnu2EX1VRky2Lpd45qvZ_g" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="gxoZyuApjEuzsuLtZuZWmQ" visible="0" canBeVaried="0" />
-                      <Parameter id="U3ukwT5VDUurv2H03J6GZw" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="qr_x2cq_Y0C6Ur-VSCP4AQ" visible="0" canBeVaried="0" />
-                      <Parameter id="KSjBJz5zI0y0e0JIGyibwg" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Iph7YhQ5KUmsZWUX2Xf2Wg" visible="0" canBeVaried="0" />
-                      <Parameter id="CNzIdPPmpUaPGXukx6HKZw" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="R-AykvxorU6Kzdi4HnNHGg" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Parameter id="J0H4HMwZSk2viXqsFKDZIA" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="aWekJ2NVAECIIbxJKJ8L5g" visible="0" canBeVaried="0" />
-                      <Transport id="4cNsPhHczkGhQyfpbJQApg" name="DrugAbsorption_trans" description="Drug absorption transcellular" mode="Logical" containerType="Transport" dimension="Amount per time" formula="nTmJfOVbg0S4bDtKDqXXvg" sourceAmount="mgzsCzTwXkGLoEv-ZBAnNQ" targetAmount="Y5D_k9113E2RRgqowuESsw">
-                        <Children>
-                          <Parameter id="aR8YmrhGDkmc_hC--zBp-Q" name="ProcessRate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="xdG_Re5dC06d-dWW03Wmmw" visible="0" canBeVaried="1" displayUnit="µmol/min">
-                            <Tags>
-                              <Tag value="DrugAbsorption_trans" />
-                              <Tag value="ProcessRate" />
-                              <Tag value="C1" />
-                              <Tag value="Lumen_colasc_ColonAscendens_cell" />
-                              <Tag value="Passive" />
-                            </Tags>
-                          </Parameter>
-                        </Children>
-                      </Transport>
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="59wWKxgQgU2MOUuTSRlv4w" name="Lumen_colasc_ColonAscendens_pls" description="Neighborhood between Lumen/Colon Ascendens and Mucosa/Colon Ascendens/Plasma" mode="Logical" containerType="Other" firstNeighbor="jhPiKsemqE2D9wuuFrqxsw" secondNeighbor="Aivr7qttHUatCWB0Vus_ew">
-                <Tags>
-                  <Tag value="Neighborhood: ColonAscendens / Plasma" />
-                </Tags>
-                <Children>
-                  <Container id="Wqh87a2EKkeQciYOncNUUg" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="KlYS9lDuK0CRmj2rY3SOzQ" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="uJR983R2Vk-Ffh8uTypLjA" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Parameter id="BfBRHgjVeESWpMzhUzSstA" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="j9rzTG61Ok-9AT5w4Qqd7g" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Parameter id="wZEPVWZ9VkOx_nFCd_yhwA" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="gHae4Hcct0a7d2opTKL_PQ" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="0f35OxOGQUu9qFIB6zpQXA" name="ArterialBlood_pls_Kidney_pls" description="Neighborhood between Arterial Blood/Plasma and Kidney/Plasma" mode="Logical" containerType="Other" firstNeighbor="qJqHlxhje0erBO7-fTj4-g" secondNeighbor="eUFCZIU4ekuNusmv0rogQA">
-                <Tags>
-                  <Tag value="Neighborhood: Plasma / Plasma" />
-                </Tags>
-                <Children>
-                  <Container id="N6FvW_skw0WC3HwemxhVhA" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Transport id="NM4NhUYj70GHnqVa1YYr1Q" name="MassTransferBloodPool2OrgPl" description="Mass transfer from Arterial Blood: Plasma to organ: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="0s7pXX0_BEaTsJz4zIGxUA" sourceAmount="n0un2GZNyUWFQsjdUS5RGA" targetAmount="E1GgL5W3o0mtgLyXCveGWQ" />
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="181v9PBhDUy0AaSTYsu4Bw" name="ArterialBlood_pls_LargeIntestine_pls" description="Neighborhood between Arterial Blood/Plasma and Large Intestine/Plasma" mode="Logical" containerType="Other" firstNeighbor="qJqHlxhje0erBO7-fTj4-g" secondNeighbor="uvQs1PS9aUqsBpd5BT5HkA">
-                <Tags>
-                  <Tag value="Neighborhood: Plasma / Plasma" />
-                </Tags>
-                <Children>
-                  <Container id="L5U8EX8PLk23Vi9x37cvcw" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Transport id="MNt9qcLsaU6QvPig4SUuRQ" name="MassTransferBloodPool2OrgPl" description="Mass transfer from Arterial Blood: Plasma to organ: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="9_cpJhct7EiVMyLtUAllUQ" sourceAmount="n0un2GZNyUWFQsjdUS5RGA" targetAmount="xpcrmRU34EqRDnqQj6ZOeA" />
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="aJdYe0fofEu_jALefw-Vig" name="ArterialBlood_pls_Liver_pls" description="Neighborhood between Arterial Blood/Plasma and Liver/Plasma" mode="Logical" containerType="Other" firstNeighbor="qJqHlxhje0erBO7-fTj4-g" secondNeighbor="5FNaxPygXkWpARUfOC0rDA">
-                <Tags>
-                  <Tag value="Neighborhood: Plasma / Plasma" />
-                </Tags>
-                <Children>
-                  <Container id="S3WP9zaTdk6MlGvnhKB7sA" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Transport id="oN8lXDE41UGdq-VjH2QH9w" name="MassTransferBloodPool2OrgPl" description="Mass transfer from Arterial Blood: Plasma to organ: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="i8Uzqki2XEenUXXXrAb2rQ" sourceAmount="n0un2GZNyUWFQsjdUS5RGA" targetAmount="T_cXaPk7BEyWVth9NnrBzw" />
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="eBzh1XStWkaL8FhNMzs4Pw" name="ArterialBlood_pls_Muscle_pls" description="Neighborhood between Arterial Blood/Plasma and Muscle/Plasma" mode="Logical" containerType="Other" firstNeighbor="qJqHlxhje0erBO7-fTj4-g" secondNeighbor="XRLei8Ut4k69NW71TsrsFA">
-                <Tags>
-                  <Tag value="Neighborhood: Plasma / Plasma" />
-                </Tags>
-                <Children>
-                  <Container id="qyGqXV9NIUS-D-_9HqujEg" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Transport id="finho5VyIECDclrjm-xYfw" name="MassTransferBloodPool2OrgPl" description="Mass transfer from Arterial Blood: Plasma to organ: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="IMSUXNeNB0OPif7VdBpDnw" sourceAmount="n0un2GZNyUWFQsjdUS5RGA" targetAmount="JbH2ysob6kW6Qm7S2hrU2g" />
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="2nCaXNW33kyc72KosAtLTA" name="ArterialBlood_pls_Pancreas_pls" description="Neighborhood between Arterial Blood/Plasma and Pancreas/Plasma" mode="Logical" containerType="Other" firstNeighbor="qJqHlxhje0erBO7-fTj4-g" secondNeighbor="cctLJe2tcEmrG89fHAxBug">
-                <Tags>
-                  <Tag value="Neighborhood: Plasma / Plasma" />
-                </Tags>
-                <Children>
-                  <Container id="-mhBaM43AUSEUIXQeTpBcw" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Transport id="yM02xkUJqkC4LBW08OcV5g" name="MassTransferBloodPool2OrgPl" description="Mass transfer from Arterial Blood: Plasma to organ: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="5SGZhd1fT0unBgqoPDyLiw" sourceAmount="n0un2GZNyUWFQsjdUS5RGA" targetAmount="5o8ad95eVkm36IzpkEUdTg" />
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="IWPVW25nlUOyD-HyXKyvaw" name="ArterialBlood_pls_Skin_pls" description="Neighborhood between Arterial Blood/Plasma and Skin/Plasma" mode="Logical" containerType="Other" firstNeighbor="qJqHlxhje0erBO7-fTj4-g" secondNeighbor="Xg7ardQtf0-u4B4xI_Q48w">
-                <Tags>
-                  <Tag value="Neighborhood: Plasma / Plasma" />
-                </Tags>
-                <Children>
-                  <Container id="3W7EqifQPU-1W2FQrQQp0A" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Transport id="DBt4A2cPgUyNCr7GFgyQag" name="MassTransferBloodPool2OrgPl" description="Mass transfer from Arterial Blood: Plasma to organ: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="CMoxK21o7k633wBlpUo8eQ" sourceAmount="n0un2GZNyUWFQsjdUS5RGA" targetAmount="FRvVMGhi8UOBMOTbm5lolA" />
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="ZRH0IyFZhEe8Y6S9NXGIsQ" name="ArterialBlood_pls_SmallIntestine_pls" description="Neighborhood between Arterial Blood/Plasma and Small Intestine/Plasma" mode="Logical" containerType="Other" firstNeighbor="qJqHlxhje0erBO7-fTj4-g" secondNeighbor="v7QydXWpf0-VYKE0_MwWVQ">
-                <Tags>
-                  <Tag value="Neighborhood: Plasma / Plasma" />
-                </Tags>
-                <Children>
-                  <Container id="WOWxzo1c10umif8yFvM0WA" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Transport id="pVNyuVzePES1l2LeP3Maog" name="MassTransferBloodPool2OrgPl" description="Mass transfer from Arterial Blood: Plasma to organ: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="ceoOi64Aj0uHsljzPu9G0A" sourceAmount="n0un2GZNyUWFQsjdUS5RGA" targetAmount="f8G7zu_9zEK_ZkVtpIfeVw" />
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="N5va1x04AEaI_ZdDfxX1Hg" name="ArterialBlood_pls_Fat_pls" description="Neighborhood between Arterial Blood/Plasma and Fat/Plasma" mode="Logical" containerType="Other" firstNeighbor="qJqHlxhje0erBO7-fTj4-g" secondNeighbor="l3cprPldy0-s1EHY_moWpQ">
-                <Tags>
-                  <Tag value="Neighborhood: Plasma / Plasma" />
-                </Tags>
-                <Children>
-                  <Container id="XTSfpM4rN0eoI_R2whavJA" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Transport id="9XJGP9e2oka5pdLjnC3w8g" name="MassTransferBloodPool2OrgPl" description="Mass transfer from Arterial Blood: Plasma to organ: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="EAovPT8yl0S8NeARfMGAQw" sourceAmount="n0un2GZNyUWFQsjdUS5RGA" targetAmount="oe9lGPCNGkOTlj2HvT3xWA" />
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="Zc0xKze_S0mVfOf_bi2w5A" name="ArterialBlood_pls_Stomach_pls" description="Neighborhood between Arterial Blood/Plasma and Stomach/Plasma" mode="Logical" containerType="Other" firstNeighbor="qJqHlxhje0erBO7-fTj4-g" secondNeighbor="HZ6pfKhao0S84LcP_vvjSQ">
-                <Tags>
-                  <Tag value="Neighborhood: Plasma / Plasma" />
-                </Tags>
-                <Children>
-                  <Container id="IsSexBciRkOLlA1tQIQLZA" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Transport id="tueEaNLugk61injTB71qGA" name="MassTransferBloodPool2OrgPl" description="Mass transfer from Arterial Blood: Plasma to organ: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="uid635Sajk6FTZcnKXOqQw" sourceAmount="n0un2GZNyUWFQsjdUS5RGA" targetAmount="bgD3avhorEm8i92Um2o6Mw" />
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="3bqy2rlJjUqjAbQiLPa2rQ" name="ArterialBlood_pls_Spleen_pls" description="Neighborhood between Arterial Blood/Plasma and Spleen/Plasma" mode="Logical" containerType="Other" firstNeighbor="qJqHlxhje0erBO7-fTj4-g" secondNeighbor="se5WEELXjEOw38dYu8tSjg">
-                <Tags>
-                  <Tag value="Neighborhood: Plasma / Plasma" />
-                </Tags>
-                <Children>
-                  <Container id="PSy6O7RKTU2dlPk_l2usEA" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Transport id="JL32JLwz_0atoCnIhTNglQ" name="MassTransferBloodPool2OrgPl" description="Mass transfer from Arterial Blood: Plasma to organ: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="IlmVUslnq0uWG44WIJTkzg" sourceAmount="n0un2GZNyUWFQsjdUS5RGA" targetAmount="89VKmmFVs0qTmpo4TCEX_A" />
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="cW6GUFAx3k-9Xdfs9OskMQ" name="ArterialBlood_bc_LargeIntestine_bc" description="Neighborhood between Arterial Blood/Blood Cells and Large Intestine/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="0_QXjFTwnEy8-V1CtkHsew" secondNeighbor="SXH64aI-W0uPsXU5nSDPlA">
-                <Tags>
-                  <Tag value="Neighborhood: BloodCells / BloodCells" />
-                </Tags>
-                <Children>
-                  <Container id="yKOo58kwHkO9Qx_IPNmQgw" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Transport id="a_Aql0YvtU-Zcp9_trU1EA" name="MassTransferBloodPool2OrgRBC" description="Mass transfer from ArterialBlood: BloodCells to organ: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="I963OEiXRkm76CTbCRQLog" sourceAmount="HVsSKkWIVECLvyey2mYIPw" targetAmount="1CoHmlwfmEyD48lxr-SSNg" />
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
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-                <Tags>
-                  <Tag value="Neighborhood: BloodCells / BloodCells" />
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-                <Children>
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-                    <Children>
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-                <Tags>
-                  <Tag value="Neighborhood: BloodCells / BloodCells" />
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-                <Children>
-                  <Container id="CwbXyl1JP0ihaQHrMKPOdQ" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Transport id="jwhNCb2ymUKYti--11CIkQ" name="MassTransferBloodPool2OrgRBC" description="Mass transfer from ArterialBlood: BloodCells to organ: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="3BIYakWNl0WU5KDZqx0s8Q" sourceAmount="HVsSKkWIVECLvyey2mYIPw" targetAmount="qMH9c4X4Ek6ugLGK4dEEug" />
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-                <Tags>
-                  <Tag value="Neighborhood: BloodCells / BloodCells" />
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-                <Children>
-                  <Container id="NAV475SY3UuyCvEEh7RxHQ" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Transport id="oAvbXbr1kEm6jglhzwgv-w" name="MassTransferBloodPool2OrgRBC" description="Mass transfer from ArterialBlood: BloodCells to organ: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="3-HfTQdlbk-1IFLVsFKJwA" sourceAmount="HVsSKkWIVECLvyey2mYIPw" targetAmount="8YO8dduw-0WdLQKfJY0mOg" />
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-                <Tags>
-                  <Tag value="Neighborhood: BloodCells / BloodCells" />
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-                <Children>
-                  <Container id="M_iM1XlGtECWHD5tSMHjiQ" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Transport id="wSxGxz7HFUGTYvFxGCpRFg" name="MassTransferBloodPool2OrgRBC" description="Mass transfer from ArterialBlood: BloodCells to organ: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="vttKidv8tkmbCaCSmBtwOA" sourceAmount="HVsSKkWIVECLvyey2mYIPw" targetAmount="NMsvr4OvokeBZq8LJ-XvXQ" />
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-                <Tags>
-                  <Tag value="Neighborhood: Plasma / Plasma" />
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-                <Children>
-                  <Container id="gLrCoRtaLkGAz9LH6a9c3g" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Transport id="hMLqcxsQiEia4zHxphIg0w" name="MassTransferBloodPool2OrgPl" description="Mass transfer from Arterial Blood: Plasma to organ: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="V3XI_-gyjE2Rn9xR3GPNhA" sourceAmount="n0un2GZNyUWFQsjdUS5RGA" targetAmount="qoaU-KhmBkSuINyqySeM2A" />
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-                <Tags>
-                  <Tag value="Neighborhood: BloodCells / BloodCells" />
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-                <Children>
-                  <Container id="7n4s4UCuWk-7jtU50u8D7g" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Transport id="2Pp-uV_cxEyY052kop1avg" name="MassTransferBloodPool2OrgRBC" description="Mass transfer from ArterialBlood: BloodCells to organ: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="abvQ3U2p8UCpcU5uvrsgjA" sourceAmount="HVsSKkWIVECLvyey2mYIPw" targetAmount="s0ARpvfc_kCXvSg1uyJo7w" />
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-                <Tags>
-                  <Tag value="Neighborhood: BloodCells / BloodCells" />
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-                      <Transport id="rccwLSbLZkqWxOZHTZ1Njw" name="MassTransferBloodPool2OrgRBC" description="Mass transfer from ArterialBlood: BloodCells to organ: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="57todndwBES4sJkZ4JKG-w" sourceAmount="HVsSKkWIVECLvyey2mYIPw" targetAmount="d0NG98bkQ0uyp6XKGUEC_Q" />
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-                <Tags>
-                  <Tag value="Neighborhood: BloodCells / BloodCells" />
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-                <Children>
-                  <Container id="MO39Yx2ZqUqQ7vQo9OAW_w" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Transport id="shcYi1QewUW5Ilg2e0B6iQ" name="MassTransferBloodPool2OrgRBC" description="Mass transfer from ArterialBlood: BloodCells to organ: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="sIgeKjvtqUyvi3NgmpST5A" sourceAmount="HVsSKkWIVECLvyey2mYIPw" targetAmount="27a1Npm_QEaEQOPqqma4rw" />
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-                <Tags>
-                  <Tag value="Neighborhood: BloodCells / BloodCells" />
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-                <Children>
-                  <Container id="V0goqTcDuk-ThqTcKEwyhg" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Transport id="yRnAeciWJ02msILJD7BdYA" name="MassTransferBloodPool2OrgRBC" description="Mass transfer from ArterialBlood: BloodCells to organ: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="1s6OCupxOU2E3MzOKMaNtw" sourceAmount="HVsSKkWIVECLvyey2mYIPw" targetAmount="REWBabOvWEqf_0a-yS75TA" />
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-                <Tags>
-                  <Tag value="Neighborhood: BloodCells / BloodCells" />
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-                <Children>
-                  <Container id="m-dxWd9orUq-6dHQ8Uf-cQ" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Transport id="QfDtOfTSTUCD3vfMOqfpXw" name="MassTransferBloodPool2OrgRBC" description="Mass transfer from ArterialBlood: BloodCells to organ: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="27sM1m-MD0C8vjrqsfxfrg" sourceAmount="HVsSKkWIVECLvyey2mYIPw" targetAmount="DhjTerwdiEag5vbskJtPZw" />
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-                <Tags>
-                  <Tag value="Neighborhood: BloodCells / BloodCells" />
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-                <Children>
-                  <Container id="bJxHGhRoz02cOtOzOUUK-Q" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Transport id="IwZ0u1mRT0q9ykK3XIAHsA" name="MassTransferBloodPool2OrgRBC" description="Mass transfer from ArterialBlood: BloodCells to organ: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="2ZaPbj2vKk6_rOcENJ2Vew" sourceAmount="HVsSKkWIVECLvyey2mYIPw" targetAmount="gACrDjDg5UuEdDtbqzvxDA" />
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-                <Tags>
-                  <Tag value="Neighborhood: BloodCells / BloodCells" />
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-                <Children>
-                  <Container id="QDBw3RGR0U2-HdGUw2tUog" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Transport id="7MfyXPMSVkSBDyj35X_kZg" name="MassTransferBloodPool2OrgRBC" description="Mass transfer from ArterialBlood: BloodCells to organ: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="-PNgNEQ90ky5pKSoJywyXw" sourceAmount="HVsSKkWIVECLvyey2mYIPw" targetAmount="gFh2BN_Bg0uEOyNf12mJCg" />
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-                <Tags>
-                  <Tag value="Neighborhood: BloodCells / BloodCells" />
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-                <Children>
-                  <Container id="4rFahWDPQUC661iwEyGl1g" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Transport id="mI2PEcGrpUmElM9tlfsWhA" name="MassTransferBloodPool2OrgRBC" description="Mass transfer from ArterialBlood: BloodCells to organ: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="E0NmBhWMK0S1CHpATzXEQA" sourceAmount="HVsSKkWIVECLvyey2mYIPw" targetAmount="PyfLvFgK0EK6vo6Wn0xZ1g" />
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-                <Tags>
-                  <Tag value="Neighborhood: Plasma / Plasma" />
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-                <Children>
-                  <Container id="3K_H2Rmfska2yGhs8GsdIg" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Transport id="L3XBn8lhZE2yQEpnWOdZFQ" name="MassTransferBloodPool2OrgPl" description="Mass transfer from Arterial Blood: Plasma to organ: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="xzsreic-7U6yHswvulOazg" sourceAmount="n0un2GZNyUWFQsjdUS5RGA" targetAmount="Zx-yrj6TNEiFakW3eAjvUw" />
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-                <Tags>
-                  <Tag value="Neighborhood: BloodCells / BloodCells" />
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-                <Children>
-                  <Container id="oMcIjMM7dEyChqIoXuVgjQ" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Transport id="a1xt1y1QSEmaMxv4T-34GA" name="MassTransferBloodPool2OrgRBC" description="Mass transfer from ArterialBlood: BloodCells to organ: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="BaeTfEmZ5kGHql0mPvsGBg" sourceAmount="HVsSKkWIVECLvyey2mYIPw" targetAmount="Obwdz__ceEWQHALue4zdrw" />
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-              <Neighborhood id="83Mf3RneWEGh6EspsIm3og" name="ArterialBlood_pls_Gonads_pls" description="Neighborhood between Arterial Blood/Plasma and Gonads/Plasma" mode="Logical" containerType="Other" firstNeighbor="qJqHlxhje0erBO7-fTj4-g" secondNeighbor="LjaheEHgMkKcij_K4QJW7g">
-                <Tags>
-                  <Tag value="Neighborhood: Plasma / Plasma" />
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-                <Children>
-                  <Container id="_xVoe5kyRkyL-pBn7G1C0A" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Transport id="bcPfbtwY2UOZEo75TKRdsA" name="MassTransferBloodPool2OrgPl" description="Mass transfer from Arterial Blood: Plasma to organ: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="1ekIJ1f5PkKXXdQkacliMw" sourceAmount="n0un2GZNyUWFQsjdUS5RGA" targetAmount="7v8TrBZxj028VHiqRTbv9A" />
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-              <Neighborhood id="XZTlxALpjkCBBeVRbFRAMQ" name="ArterialBlood_pls_Brain_pls" description="Neighborhood between Arterial Blood/Plasma and Brain/Plasma" mode="Logical" containerType="Other" firstNeighbor="qJqHlxhje0erBO7-fTj4-g" secondNeighbor="bT3W5WSK-UqwySKFP2SkAQ">
-                <Tags>
-                  <Tag value="Neighborhood: Plasma / Plasma" />
-                </Tags>
-                <Children>
-                  <Container id="raPeP9iRmEW2gmPYtNUklA" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Transport id="ruB2OXmvDkWoFSntBb_e2w" name="MassTransferBloodPool2OrgPl" description="Mass transfer from Arterial Blood: Plasma to organ: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="2FQtkviBxUC80hun68JNkg" sourceAmount="n0un2GZNyUWFQsjdUS5RGA" targetAmount="rOGC7KehEkmFXF9mQPDiZQ" />
-                    </Children>
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-                <Tags>
-                  <Tag value="Neighborhood: BloodCells / BloodCells" />
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-                <Children>
-                  <Container id="V9XOaNArDUeJBaGoSOMsjg" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="qCQS5ydcoUmmmduLIMuDyQ" name="Mass transfer rate (mucosa to portal vein blood cells)" description="Mass transfer rate (mucosa to portal vein blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="_TKtQ5FSMUiH0JhO0qlXJw" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Transport id="1lko4hd3J0CtGSltCZ9ddw" name="MassTransferMucosaToPveBC" description="Mass transfer from Mucosa:Blood Cells To Portal Vein: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="mT7rZKj5Qkydo30kHywVIQ" sourceAmount="F5meuBt0ck6H-U7fLJ-DUg" targetAmount="3A4PxVITtUOpr85RBMQZlg" />
-                    </Children>
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-              <Neighborhood id="6Wzbazhxd0i5OEgx57kN1g" name="Duodenum_pls_PortalVein_pls" description="Neighborhood between Duodenum/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="5qa_dNfzPEqENSftAboAkA" secondNeighbor="-zX9e5Gif0qLF9-buV_xlA">
-                <Tags>
-                  <Tag value="Neighborhood: Plasma / Plasma" />
-                </Tags>
-                <Children>
-                  <Container id="yakhAjWwNkm9gHrtW8l5oQ" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="AQpp0dMp8US2CDbXPhl2mg" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="7_quIdIey0K7HxmDN5ARzQ" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Transport id="VBNap-IHwkW0TD4WyHoctw" name="MassTransferMucosaToPvePlasma" description="Mass transfer from Mucosa:Plasma To Portal Vein: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="O0RYF4RVTUiwmsNlwc2i7Q" sourceAmount="9U0qncgJp0GzhMN51sFuvg" targetAmount="hqBDuJ9j9Eqjy73I0KZSUA" />
-                    </Children>
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-              <Neighborhood id="3ufEz4fkjUq-M8cHy0YgSQ" name="Lumen_duo_Duodenum_cell" description="Neighborhood between Lumen/Duodenum and Mucosa/Duodenum/Intracellular" mode="Logical" containerType="Other" firstNeighbor="RBDgGJ__rUCEJi-Z5h0eyg" secondNeighbor="34MfH5c9wEKhN-FvYBmvow">
-                <Tags>
-                  <Tag value="Neighborhood: Duodenum / Intracellular" />
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-                <Children>
-                  <Container id="LzddDaGHlUu7D0Ukcm_0vg" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="mcEin6uiVUmkAAI8Y_6WOg" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Iph7YhQ5KUmsZWUX2Xf2Wg" visible="0" canBeVaried="0" />
-                      <Parameter id="9eaLnOcE9ka81etofnFZww" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="ezAHDPnckEKYf8L1jOtGfw" visible="0" canBeVaried="0" />
-                      <Parameter id="PbArjjMrkE6z8KeR8HWbKg" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="2IVWcgM31UCSVl8zMDnDhw" visible="0" canBeVaried="0" />
-                      <Parameter id="86uQ75YFrkycC2WLxv5hAw" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DNGx_vFWp0KdOb7CGcoTLQ" visible="0" canBeVaried="0" />
-                      <Parameter id="BlqVNt8Ky06WgE7oIba4RA" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="LcUCvhU3W0udtbpS1KVhEQ" visible="0" canBeVaried="0" />
-                      <Parameter id="dWZH_5UUQkSpjG375tnftw" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="VVc0X37OJkiFkhq32_OoRA" visible="0" canBeVaried="0" />
-                      <Parameter id="bNoDuoh6dke-6xrQfvkRhQ" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="u_Q4X_iktkirUBSGXEyg9g" visible="0" canBeVaried="0" />
-                      <Parameter id="JzReeS-0y0KRE4WLKq-OOA" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="kpE3uXS5zUCRkpfRlyleBQ" visible="0" canBeVaried="0" />
-                      <Parameter id="AJmNW9G8dUG06p8-9han9w" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="PEhoVdLppU-G3xULjX_71g" visible="0" canBeVaried="0" />
-                      <Parameter id="l-Q-IaeJ4EKISyNQLOxypg" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="pGvG5UNdC0Sot3_d3Qdvag" visible="0" canBeVaried="0" />
-                      <Parameter id="PTPS7Ug0SEy8IrH7nJJnaw" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="jJfeJ2YxEki9TK9XP6uUMA" visible="0" canBeVaried="0" />
-                      <Parameter id="Vw52eqg9XE-rRp41YCeJig" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DNF0kWPUFk-rtSd0Ng1Mkw" visible="0" canBeVaried="0" />
-                      <Parameter id="bG-AobM9D0CeCGTAWWSQCw" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="qr_x2cq_Y0C6Ur-VSCP4AQ" visible="0" canBeVaried="0" />
-                      <Parameter id="s6egl4l9-0GnYBfz57cpnw" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="KQgllSQtqk2EfhX37WilDQ" visible="0" canBeVaried="0" />
-                      <Parameter id="FMrTTHpBJ0-PxeuIPHSVYw" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="aWekJ2NVAECIIbxJKJ8L5g" visible="0" canBeVaried="0" />
-                      <Parameter id="vF6C-rqwl0O-453nHy8Wcw" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="nWEfS4ktXUC6-M5u3M80Cw" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Parameter id="uMAd-Vwf8UqVjuAafaZ0sA" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="yWFsmfxS1Uqt7Wa4dk5OtA" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Parameter id="Cwaizj0Ffk2HRquxloL8Fg" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="gxoZyuApjEuzsuLtZuZWmQ" visible="0" canBeVaried="0" />
-                      <Parameter id="N_WHyfQgR0O1jbMcQqjAAQ" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="3xvkxp6qK06bn4DgEtYULA" visible="0" canBeVaried="0" />
-                      <Parameter id="NDbz0TBbxU2voP4kP0Ni8w" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="7NEiCDSKM0i6GhEpoWb-Mw" visible="0" canBeVaried="0" />
-                      <Parameter id="9fpo7tKULEWxB7hlyfSaSw" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="vzTIjtq1GEeaU1_8TNBl6Q" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Parameter id="JzqSZmOwUU-IUpdGqglRGg" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="bOPO_JT8sEOF6PITZSGGVg" visible="0" canBeVaried="0" />
-                      <Parameter id="lAo41HaFuEayKA1EfIXEjA" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="aZYSS2yfyEqUEbGBDu38yg" visible="0" canBeVaried="0" />
-                      <Parameter id="4CWgLAZAgkG2tDtsMmAXPQ" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="XQ0ZCj09k0Ot8zIL2YDpeQ" visible="0" canBeVaried="0" />
-                      <Parameter id="Fz30pQ2BTEuxOvx1V6fouw" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="ItmP-hADIEmAqZFL21ODjw" visible="0" canBeVaried="1" />
-                      <Parameter id="NW5jnMXZtkOyO53gDOXRfQ" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="cwd2O_uC-Ui_xMEQxkKh2Q" visible="0" canBeVaried="0" />
-                      <Parameter id="5oSS086cAU6NdGZ8CGm_lw" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Co8Mz9t60UCZ20SnC9HIig" visible="0" canBeVaried="0" />
-                      <Parameter id="vEacb5DabkKvVD4cStPodg" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="NayKFXLotUmsuuhWiMUiVg" visible="0" canBeVaried="0" />
-                      <Parameter id="EdILnAZNF0i7h6P1ILFQrQ" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="0IIh6FJV0UKyrimES0f1xg" visible="0" canBeVaried="0" />
-                      <Transport id="RD7OpO4YmESaUkYTSTMadA" name="DrugAbsorption_trans" description="Drug absorption transcellular" mode="Logical" containerType="Transport" dimension="Amount per time" formula="9irwJgbWFk6VZhk0OwUqqg" sourceAmount="BaeHcf6VhUyw3ftOPt1iIg" targetAmount="OmmrIkIo20K9O_8M3GTn6Q">
-                        <Children>
-                          <Parameter id="b9Wh6VPPaUylULTPp8uGPA" name="ProcessRate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="jezBWAvkAEuYQcoMQWnoLQ" visible="0" canBeVaried="1" displayUnit="µmol/min">
-                            <Tags>
-                              <Tag value="DrugAbsorption_trans" />
-                              <Tag value="ProcessRate" />
-                              <Tag value="C1" />
-                              <Tag value="Lumen_duo_Duodenum_cell" />
-                              <Tag value="Passive" />
-                            </Tags>
-                          </Parameter>
-                        </Children>
-                      </Transport>
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="8Pi4xI9RcU6c9L8GsDG6oA" name="Lumen_duo_Duodenum_pls" description="Neighborhood between Lumen/Duodenum and Mucosa/Duodenum/Plasma" mode="Logical" containerType="Other" firstNeighbor="RBDgGJ__rUCEJi-Z5h0eyg" secondNeighbor="5qa_dNfzPEqENSftAboAkA">
-                <Tags>
-                  <Tag value="Neighborhood: Duodenum / Plasma" />
-                </Tags>
-                <Children>
-                  <Container id="abCXefAUxEuW8TrNvtDC3Q" name="C1" mode="Logical" containerType="Molecule">
-                    <Children>
-                      <Parameter id="KU4xyeCAmUeliopIZSOpwA" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="ZTWtG56P2kCn9KPdhJsqJQ" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Parameter id="zqnIQ8kV70qjgRDhFnwWbQ" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="x6yvLBojJ0WjuJEGpQIl_g" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Parameter id="USXdO-GxQ0iTvXOGalzojA" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="7S6GOVzI2EmPL9g7hbUE9A" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                      <Transport id="CP5PZLHJ5UGE1kT2bA_Cbw" name="DrugAbsorption_para" description="Drug absorption paracellular" mode="Logical" containerType="Transport" dimension="Amount per time" formula="7ha6v5uaiEyGy1hSEvh05A" sourceAmount="BaeHcf6VhUyw3ftOPt1iIg" targetAmount="9U0qncgJp0GzhMN51sFuvg">
-                        <Children>
-                          <Parameter id="P7ZAMGIMWUyxHm8xedzXOg" name="ProcessRate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="9GAf_iApvk-8Ls8mKBR10g" visible="0" canBeVaried="1" displayUnit="µmol/min">
-                            <Tags>
-                              <Tag value="DrugAbsorption_para" />
-                              <Tag value="ProcessRate" />
-                              <Tag value="C1" />
-                              <Tag value="Lumen_duo_Duodenum_pls" />
-                              <Tag value="Passive" />
-                            </Tags>
-                          </Parameter>
-                        </Children>
-                      </Transport>
-                    </Children>
-                  </Container>
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="SDDTF4E_ukeZLP016WlpQQ" name="ColonTransversum_cell__VenousBlood_pls" description="Neighborhood between LargeIntestine/Mucosa/ColonTransversum/Interstitial and Venous Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="uSnfTCjzEEKsrn-SJCCw0g" secondNeighbor="J2AzZMiPQUibGWyUqz4XLA">
-                <Tags>
-                  <Tag value="Neighborhood: Interstitial / Plasma" />
-                </Tags>
-                <Children>
-                  <Container id="YkXZy-gk7E6pMNk7DiBM6g" name="C1" mode="Logical" containerType="Molecule" />
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="cj3ZeVukREaLLG38FEnmgw" name="ColonDescendens_cell__VenousBlood_pls" description="Neighborhood between LargeIntestine/Mucosa/ColonDescendens/Interstitial and Venous Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="YUV1KDlDvUS4N8X86jTR_w" secondNeighbor="J2AzZMiPQUibGWyUqz4XLA">
-                <Tags>
-                  <Tag value="Neighborhood: Interstitial / Plasma" />
-                </Tags>
-                <Children>
-                  <Container id="PKiRd-XS2k2Dgn4KYU-srg" name="C1" mode="Logical" containerType="Molecule" />
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="1jrf_8POzUeagCpv5fG1Mg" name="ColonSigmoid_cell__VenousBlood_pls" description="Neighborhood between LargeIntestine/Mucosa/ColonSigmoid/Interstitial and Venous Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="5HpeQ-ekKkOS2la6bazFiA" secondNeighbor="J2AzZMiPQUibGWyUqz4XLA">
-                <Tags>
-                  <Tag value="Neighborhood: Interstitial / Plasma" />
-                </Tags>
-                <Children>
-                  <Container id="AJ1DPMVMIEOEbf6kuTTxvw" name="C1" mode="Logical" containerType="Molecule" />
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="l_0o0r28u0q_ExIA5dznjw" name="Rectum_cell__VenousBlood_pls" description="Neighborhood between LargeIntestine/Mucosa/Rectum/Interstitial and Venous Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="k2lXslAcv0O9A3Owj-loLg" secondNeighbor="J2AzZMiPQUibGWyUqz4XLA">
-                <Tags>
-                  <Tag value="Neighborhood: Interstitial / Plasma" />
-                </Tags>
-                <Children>
-                  <Container id="L6YGFwvFoUSzk-zIldvYLw" name="C1" mode="Logical" containerType="Molecule" />
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="aW2uqgvSCECXG3z2yzKCpg" name="UpperJejunum_cell__VenousBlood_pls" description="Neighborhood between SmallIntestine/Mucosa/UpperJejunum/Interstitial and Venous Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="MX7UE1AYnEeTRDJ1HM7CBg" secondNeighbor="J2AzZMiPQUibGWyUqz4XLA">
-                <Tags>
-                  <Tag value="Neighborhood: Interstitial / Plasma" />
-                </Tags>
-                <Children>
-                  <Container id="H1Yj0x5xdkqvKmplP1vsnQ" name="C1" mode="Logical" containerType="Molecule" />
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="x2HRkuWj_kqoKAvcZf5qAA" name="ColonAscendens_cell__VenousBlood_pls" description="Neighborhood between LargeIntestine/Mucosa/ColonAscendens/Interstitial and Venous Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="uvlcQsL-GUCowlN-t4ha-g" secondNeighbor="J2AzZMiPQUibGWyUqz4XLA">
-                <Tags>
-                  <Tag value="Neighborhood: Interstitial / Plasma" />
-                </Tags>
-                <Children>
-                  <Container id="CjzLecHtKkCF859PnvDLDw" name="C1" mode="Logical" containerType="Molecule" />
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="DWurbkPEr0Oout28flcp4g" name="LowerIleum_cell__VenousBlood_pls" description="Neighborhood between SmallIntestine/Mucosa/LowerIleum/Interstitial and Venous Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="uqiskikve0-qI31H7jOgWg" secondNeighbor="J2AzZMiPQUibGWyUqz4XLA">
-                <Tags>
-                  <Tag value="Neighborhood: Interstitial / Plasma" />
-                </Tags>
-                <Children>
-                  <Container id="6ZHZuA1ns06tOOUs0rr0VA" name="C1" mode="Logical" containerType="Molecule" />
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="twXNNHPVYkOKQ2B5Bvx4Jg" name="UpperIleum_cell__VenousBlood_pls" description="Neighborhood between SmallIntestine/Mucosa/UpperIleum/Interstitial and Venous Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="mL_v9Y4FbUCAI1t4VRNB6g" secondNeighbor="J2AzZMiPQUibGWyUqz4XLA">
-                <Tags>
-                  <Tag value="Neighborhood: Interstitial / Plasma" />
-                </Tags>
-                <Children>
-                  <Container id="EPoALHLdvUyX0TEva4H8aQ" name="C1" mode="Logical" containerType="Molecule" />
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="Gt__CONpF0OhEo7cJyDO8Q" name="LowerJejunum_cell__VenousBlood_pls" description="Neighborhood between SmallIntestine/Mucosa/LowerJejunum/Interstitial and Venous Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="QujFSUBKfUuVAqdGlF3CiA" secondNeighbor="J2AzZMiPQUibGWyUqz4XLA">
-                <Tags>
-                  <Tag value="Neighborhood: Interstitial / Plasma" />
-                </Tags>
-                <Children>
-                  <Container id="Vk1JrbAtSUaVINro9xLpAg" name="C1" mode="Logical" containerType="Molecule" />
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="k8htIotSMkmnRAnMoE-Ghw" name="Duodenum_cell__VenousBlood_pls" description="Neighborhood between SmallIntestine/Mucosa/Duodenum/Interstitial and Venous Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="qdfrt7fje02lpLnQb4CGDw" secondNeighbor="J2AzZMiPQUibGWyUqz4XLA">
-                <Tags>
-                  <Tag value="Neighborhood: Interstitial / Plasma" />
-                </Tags>
-                <Children>
-                  <Container id="PlXDIeeyAE2KRP9UoRv8-g" name="C1" mode="Logical" containerType="Molecule" />
-                </Children>
-              </Neighborhood>
-              <Neighborhood id="9WoZcq0H0kmbVJbKkm4qAg" name="Caecum_cell__VenousBlood_pls" description="Neighborhood between LargeIntestine/Mucosa/Cecum/Interstitial and Venous Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="3hhWlW8CU02dQMHm8E1PTg" secondNeighbor="J2AzZMiPQUibGWyUqz4XLA">
-                <Tags>
-                  <Tag value="Neighborhood: Interstitial / Plasma" />
-                </Tags>
-                <Children>
-                  <Container id="Zd38a35MFUCXYqu8uH7O_A" name="C1" mode="Logical" containerType="Molecule" />
-                </Children>
-              </Neighborhood>
-            </Children>
-          </Container>
-          <Container id="TXyJH4Fec0quOCxr9Lo0BQ" name="C1" icon="Drug" mode="Logical" containerType="Molecule">
-            <Children>
-              <Parameter id="LogydllwZkqTfXLPinzZLg" name="P_bc_pls_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Global" visible="0" canBeVaried="1" value="1" />
-              <Parameter id="I6yNhAeSO0eXj4gCSWFD3g" name="Intestinal permeability (paracellular)" description="Intestinal permeability via paracellular route" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" buildMode="Global" visible="1" canBeVaried="1" value="0" displayUnit="cm/min" />
-              <Parameter id="0xrwhOcQnUyNhNeu9aWEIw" name="Intestinal permeability (transcellular)" description="Intestinal permeability via transcellular route" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="FZByH7ZifECWGMDiz4CpJg" buildMode="Global" visible="1" canBeVaried="1" displayUnit="cm/min" />
-              <Parameter id="lA92jQXZoEK5svyWDnbMzg" name="Mucosa permeability scale factor (transcellular)" description="Used for scaling mucosa permeability with intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="ehgWYV_EJEWSz4KTMSaHEA" buildMode="Global" visible="0" canBeVaried="0" />
-              <Parameter id="ycec4neRz0CeGlJFpqtf2Q" name="P (plasma-&gt;blood cells)" description="Permeability from plasma to blood cells" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="ty_gSWYhkEWvqtbFzecJIQ" buildMode="Global" visible="1" canBeVaried="1" displayUnit="cm/min" />
-              <Parameter id="g4FRDFVQFUau0GflTM8uZQ" name="Default Intestinal permeability (transcellular)" description="Default Intestinal permeability via transcellular route" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="YNvMyQ1PfEaBNZlQuY5PBQ" buildMode="Global" visible="0" canBeVaried="0" displayUnit="cm/min" />
-              <Parameter id="XMaXdkmSCEeFmWyXnfR-9Q" name="P_pls_bc_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Global" visible="0" canBeVaried="1" value="1" />
-              <Parameter id="JFwn2cebVEuqaDHQxK-Ylg" name="Partition coefficient (blood cells/plasma)" description="Partition coefficient between blood cells and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="MksjF8RwYUSL0uuZ-v1Qhw" buildMode="Global" visible="1" canBeVaried="1" />
-              <Parameter id="MS710_nAy06hOa3hJqMTRg" name="P (blood cells-&gt;plasma)" description="Permeability from blood cells to plasma" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="eAgoY6lGv0GXCJvh-kiFmw" buildMode="Global" visible="1" canBeVaried="1" displayUnit="cm/min" />
-              <Parameter id="9EiZ0M7WTE2uVzqJaYm4tQ" name="Fraction unbound (plasma)" description="Fraction unbound in plasma" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" formula="XtxH8thQqkmsqNht-XoBPg" buildMode="Global" visible="1" canBeVaried="0" />
-              <Parameter id="KTFvn4BVJESgrWTNqLtyxQ" name="Blood/Plasma concentration ratio" description="Blood to plasma concentration ratio" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="QtcZRSZ5fEmZZz5_CXaeWQ" buildMode="Property" visible="1" canBeVaried="1" />
-              <Parameter id="qUQraUAhW0emgOKLqNd6Og" name="pKa_TwoAcids_0" description="Smallest acid pKa for compound with 2 acid groups" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="s0Mefd8-PkSSwCMOj0JI9A" buildMode="Property" visible="0" canBeVaried="0" />
-              <Parameter id="FC5B9QnfxkufD_SJiBQSqA" name="pKa_pH_WS_sol_K2" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="i4YC4LlNGUKarduD13pkQA" buildMode="Property" visible="0" canBeVaried="0" />
-              <Parameter id="h564Gb9OIU2JsNpQBLssmw" name="pKa_pH_WS_sol_K3" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="T5ybd5Mv2UKiQgHFcr4KMQ" buildMode="Property" visible="0" canBeVaried="0" />
-              <Parameter id="d1K--Lm_QkK4GujUyUaHnA" name="pKa_pH_WS_sol_K4" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="D41EV1kTt02fb6tvx5APZA" buildMode="Property" visible="0" canBeVaried="0" />
-              <Parameter id="rB6vbMMd80a0MyhtN94_Aw" name="pKa_pH_WS_sol_K5" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="S75mCMNVLEOYLuIYTrTUsQ" buildMode="Property" visible="0" canBeVaried="0" />
-              <Parameter id="pfrX7EhoQUmuU6c8ItG_kA" name="pKa_pH_WS_sol_K6" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="8cOwldCgCEeWOsJgKitq8A" buildMode="Property" visible="0" canBeVaried="0" />
-              <Parameter id="J452dP4k_kK3gTEEfw3a9A" name="pKa_pH_WS_sol_K7" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="w4P6yOBKR0yDEZFauB3y3Q" buildMode="Property" visible="0" canBeVaried="0" />
-              <Parameter id="9rwi62Vzak2zoLYcWB6rSw" name="pKa_pH_WS_sol_K8" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="N_UfRr5SWEy57-fkRKVixw" buildMode="Property" visible="0" canBeVaried="0" />
-              <Parameter id="timEcsywVE2_o4Re24XVCg" name="pKa_ThreeAcids_0" description="Smallest acid pKa for compound with 3 acid groups" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="6z6zpNIyZE-HyMgYgU0_ZQ" buildMode="Property" visible="0" canBeVaried="0" />
-              <Parameter id="JJqZI6mkikG5qRpHcPWB7g" name="pKa_ThreeAcids_1" description="Middle acid pKa for compound with 3 acid groups" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="p_ZTpEPPJEWfXco5ga8PAQ" buildMode="Property" visible="0" canBeVaried="0" />
-              <Parameter id="W8ptm27uaEaUe6-GkN-oWg" name="pKa_ThreeBases_1" description="Middle base pKa for compound with 3 base groups" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="26PkWqM0tUCiWogDJJAdfw" buildMode="Property" visible="0" canBeVaried="0" />
-              <Parameter id="VszokE7WI0SGUR1_-_c-Kw" name="Total oral drug mass" description="Total oral drug mass" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" buildMode="Property" visible="0" canBeVaried="0" value="0" displayUnit="µmol" />
-              <Parameter id="Ag3xoM64Z0ez-qkbLlVvBg" name="pKa_TwoAcids_1" description="Middle acid pKa for compound with 2 acid groups" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="lXgh2nTK2UyHBOncZSClnw" buildMode="Property" visible="0" canBeVaried="0" />
-              <Parameter id="rcJ27CUy406p3BiQ4UVGug" name="pKa_TwoBases_0" description="Smallest base pKa for compound with 2 base groups" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="jOMq-j8VzEexIAhS6niUSw" buildMode="Property" visible="0" canBeVaried="0" />
-              <Parameter id="4VvcZ4ezI02ZXVDB1wlmNg" name="pKa_TwoBases_1" description="Middle base pKa for compound with 2 base groups" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IqjHNx4ZkkG_1cSG_HvBGw" buildMode="Property" visible="0" canBeVaried="0" />
-              <Parameter id="4RO2KPRbq0mEnaVRCaV9yw" name="Plasma protein binding partner" description="Plasma protein to which the drug is predominantly bound. The ontogeny of the two most important plasma protein binding partners, albumin and α1-acid glycoprotein (AGP) is available in the PK-Sim database so that the fraction unbound in plasma can be scaled to children using the ontogeny of the respective protein. If  the binding partner is neither albumin nor AGP  or if scaling to children is not of interest, the third alternative (unknown) can be used. Please note that any other ontogeny can be uploaded for the scaling to children using the Population Simulation Toolbox in MoBi" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="0" value="1" />
-              <Parameter id="Db6OsdWquEuvhd7GtATwfw" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="mYG_VbdnKkucmQfIKIeDBA" buildMode="Property" visible="0" canBeVaried="0" />
-              <Parameter id="wm5jPnKSC0yEeEQEkc8wbQ" name="pKa_ThreeBases_0" description="Smallest base pKa for compound with 3 base groups" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="vsVlFn8Gnke5hAcBu4s7tA" buildMode="Property" visible="0" canBeVaried="0" />
-              <Parameter id="eNJmgzj1zkyySNYkUJrSvQ" name="pKa_Base_1" description="Middle base pKa" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="1twxflFbwkmgOTsDPAYZNg" buildMode="Property" visible="0" canBeVaried="0" />
-              <Parameter id="xNAUIABYH0abKU-26YODbA" name="pKa_Bases_Count" description="Number of basic groups in compound" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="pmIVtDZkEkKf8McLFoFRTw" buildMode="Property" visible="0" canBeVaried="0" />
-              <Parameter id="i-9d1VEC-Uyi2UzRfHqpQw" name="base_For_KaPL_Factor" description="Supporting parameter for calculation of pKa- and pH- dependent values of KaPL" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="0" canBeVaried="0" value="20" />
-              <Parameter id="7kKOg2lNyEacOpoaypWQOw" name="base_For_logD_Factor" description="Supporting parameter for calculation of pKa- and pH- dependent logD" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="0" canBeVaried="0" value="0.001" />
-              <Parameter id="o2rhFvRx2k-WcHD8EmqASg" name="base_For_P_cell_Factor" description="Supporting parameter for calculation of pKa- and pH- dependent permeability to/from cells" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="0" canBeVaried="0" value="0.001" />
-              <Parameter id="0Lk7xgrdl0-wAj2nLOVy8A" name="BP_ALBUMIN" description="Constant for binding partner albumin" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="0" canBeVaried="0" value="1" />
-              <Parameter id="0NdfoukH70mwa4iXmCR7lA" name="pKa value 2" description="pKa value" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="1" value="0" />
-              <Parameter id="2V7b0CUJW0Oa76hp4BEF8A" name="base_For_Pint_Factor" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="0" canBeVaried="0" value="0.1" />
-              <Parameter id="HQG9CIWbS0W9YflPMOpZFw" name="Is strong base" description="Supporting parameter for partition coeffs in RR-Modell (at least one basic pKa&gt;=7)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="wqxMC7FHSk6ZnzChs_rVjQ" buildMode="Property" visible="0" canBeVaried="0" />
-              <Parameter id="Se1VvJVBa0CGuzJFM3rVTQ" name="Is triprotic acid" description="Is triprotic acid" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="cs2GyI1RhUqfhpI27ALg8w" buildMode="Property" visible="0" canBeVaried="0" />
-              <Parameter id="4fmFNiBZJkSGxhHrfbu2Ew" name="Is triprotic base" description="Is triprotic base" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="pzFR3JQu8kq3iIVFUxFSIw" buildMode="Property" visible="0" canBeVaried="0" />
-              <Parameter id="-qN_b6pnWEqVkSQnhVicXg" name="Molecular weight" description="Molecular weight" persistable="0" isFixedValue="0" dim="Molecular weight" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="1" value="4E-07" displayUnit="g/mol" />
-              <Parameter id="5RO3g3EgQUKMZRAfTXvbQA" name="Is neutral" description="Supporting parameter for partition coeffs in RR-Modell" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="qNxcuaaDqEeUpZMSXsEloA" buildMode="Property" visible="0" canBeVaried="0" />
-              <Parameter id="_oOH-82ni0q85P4alEe6cA" name="pKa value 1" description="pKa value" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="1" value="0" />
-              <Parameter id="H3Y9b7l0mkm3fP67e05vNg" name="Is monoprotic base monoprotic acid" description="Is monoprotic base monoprotic acid" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="XpOra6s9fU6Zb3dnLLpKNw" buildMode="Property" visible="0" canBeVaried="0" />
-              <Parameter id="RcZ8r_1j9kGT8prttQp6JQ" name="pKa_Acid_0" description="Smallest acid pKa" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="9qWGWfx1LE-HJd7wEU7gWA" buildMode="Property" visible="0" canBeVaried="0" />
-              <Parameter id="1K_CFU06mkCGPbobE9iDYw" name="pKa_Acid_1" description="Middle acid pKa" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="V48a2jYvVkGeBTXoaNlFAQ" buildMode="Property" visible="0" canBeVaried="0" />
-              <Parameter id="16uaUyy1CkOEukQ7UfZ5GQ" name="pKa_Acid_2" description="Largest acid pKa" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="fKj8AmTJMEqjPMaHycmlfQ" buildMode="Property" visible="0" canBeVaried="0" />
-              <Parameter id="9wCZqgNpoUGruoRKQS_udQ" name="pKa_Acids_Count" description="Number of acidic groups in compound" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="MIMzcgTPB0SAE2F2mDlong" buildMode="Property" visible="0" canBeVaried="0" />
-              <Parameter id="intA5YkSNkmhf5oGHFNflg" name="pKa_Base_0" description="Smallest base pKa" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="vYx4iwDAmU-an-pVx0lXVQ" buildMode="Property" visible="0" canBeVaried="0" />
-              <Parameter id="xm1v_X05zEaCAICS_MwdGg" name="pKa_Base_2" description="Largest base pKa" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="qGAulqDpdUuQut3VPzus6g" buildMode="Property" visible="0" canBeVaried="0" />
-              <Parameter id="h9i_TzcrCUCx0ff0T5WYjg" name="pKa_OneAcid_0" description="Smallest acid pKa for compound with 1 acid group" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="qXpnysKAm0yYOBz6d0Id0Q" buildMode="Property" visible="0" canBeVaried="0" />
-              <Parameter id="1gxtQxelO0KznTJnTxNAHg" name="pKa_OneBase_0" description="Smallest base pKa for compound with 1 base group" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="twYOLjoRCk6zcyUa5OtbZw" buildMode="Property" visible="0" canBeVaried="0" />
-              <Parameter id="KBrWPokeN0CmQHdTYTgOCA" name="pKa_pH_WS_sol_F1" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="gc3We5xZtk-d0f6uMhIxyg" buildMode="Property" visible="0" canBeVaried="0" />
-              <Parameter id="yeEP4Vv4j0Kkp8BgVSV4nA" name="pKa_pH_WS_sol_F2" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Yq6HGneFQ0GexBDZQ4GCfw" buildMode="Property" visible="0" canBeVaried="0" />
-              <Parameter id="NcjO6XiHikW2bu8gJMyb8w" name="pKa_pH_WS_sol_F3" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CvS69ehsqEqExRoZokY2nQ" buildMode="Property" visible="0" canBeVaried="0" />
-              <Parameter id="Qyf2GDGLvEKjBY8IplKkYg" name="pKa value 0" description="pKa value" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="1" value="0" />
-              <Parameter id="tR9VYSG96k2Wa2upLtHflw" name="Effective molecular weight" description="Effective molecular weight" persistable="0" isFixedValue="0" dim="Molecular weight" quantityType="Parameter" formula="8K6i3pwGJEeL_1ZwIwSfLQ" buildMode="Property" visible="1" canBeVaried="0" displayUnit="g/mol" />
-              <Parameter id="W_skljocW02L43oFqX2jbQ" name="pKa_pH_WS_sol_K1" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="uD-Rl4F2nkelq1ZPXoQOOw" buildMode="Property" visible="0" canBeVaried="0" />
-              <Parameter id="w0zBnFMB5EOGYx_3ZTmb8w" name="BP_UNKNOWN" description="Constant for binding partner unknown" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="0" canBeVaried="0" value="2" />
-              <Parameter id="C983TG6oqEelFWNs2bEIzQ" name="Br" description="Number of bromine atoms in molecule" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="0" value="0" />
-              <Parameter id="KrNw2SNRi0KvEuI_aYZvVg" name="Calculated specific intestinal permeability (transcellular)" description="Calculated specific intestinal permeability (transcellular)" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="YdWY6LEFy0eilzVmzYcSrQ" buildMode="Global" visible="0" canBeVaried="0" displayUnit="cm/min" />
-              <Parameter id="benv0wsWgkmkwRo9oy7YGg" name="Cl" description="Number of chlorine atoms in molecule" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="0" value="0" />
-              <Parameter id="772qNP0ECUeBik_zhdh0VA" name="Compound type 0" description="Compound type (-1: acid, +1: base, 0: neutral)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="0" value="0" />
-              <Parameter id="NrBiHpt0YUKCBIL-B2DoiQ" name="Compound type 1" description="Compound type (-1: acid, +1: base, 0: neutral)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="0" value="0" />
-              <Parameter id="OTu0fF_igkSKXESpYrN8Gw" name="Compound type 2" description="Compound type (-1: acid, +1: base, 0: neutral)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="0" value="0" />
-              <Parameter id="vsO5HbD6N0mvfd1EiG4B5w" name="CT_ACID" description="Constant for compound type acid" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="0" canBeVaried="0" value="-1" />
-              <Parameter id="TqaN84oGokuWpdKc4q_X4A" name="CT_BASE" description="Constant for compound type base" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="0" canBeVaried="0" value="1" />
-              <Parameter id="JL7SG-rG5kaplbtU-IIBtw" name="Is small molecule" description="Treat compound as small molecule or not (if not, both organ specific and intestinal permeability will be set to zero)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="0" canBeVaried="0" value="1" />
-              <Parameter id="c7X0Cp8BeEi6z3LyGAiqOA" name="BP_AGP" description="Constant for binding partner α1-acid glycoprotein" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="0" canBeVaried="0" value="0" />
-              <Parameter id="2_Fuu_fq0k-5zy03XyQUCw" name="F" description="Number of fluorine atoms in molecule" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="0" value="0" />
-              <Parameter id="YwHCoHvWBUqYoeZo4-wD_A" name="Has halogens" description="Supporting parameter for compound" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="k56iilpP7EadJHMzXDwHaQ" buildMode="Property" visible="0" canBeVaried="0" />
-              <Parameter id="JJ_17RET2EuiJplJcEGW1g" name="I" description="Number of iodine atoms in molecule" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="0" value="0" />
-              <Parameter id="OGlV1B_5Qkajlfpdz5VuJA" name="Is diprotic acid" description="Is diprotic acid" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="3DmkSew8p0GGodshsXS0sQ" buildMode="Property" visible="0" canBeVaried="0" />
-              <Parameter id="heqiZ5OtPk6iVcabJryvNA" name="Is diprotic base" description="Is diprotic base" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="NEYpxLKXu0K_jNy9cG2oWw" buildMode="Property" visible="0" canBeVaried="0" />
-              <Parameter id="mKlhv7_mIkaVYtZ5TvMDgg" name="Is diprotic base monoprotic acid" description="Is diprotic base monoprotic acid" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="64jNZ-BViEmjdH_saCv85w" buildMode="Property" visible="0" canBeVaried="0" />
-              <Parameter id="UyglOKRcXkiqL331TT4X3w" name="Is floating in lumen" description="Is floating in lumen" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="0" canBeVaried="0" value="1" />
-              <Parameter id="frk_tSYdiE-MJZx2-QivEw" name="Is monoprotic acid" description="Is monoprotic acid" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="xUOQ010TDEuL3_OxNUkCYg" buildMode="Property" visible="0" canBeVaried="0" />
-              <Parameter id="sIq0mZmPE0OiD5HKARWwnQ" name="Is monoprotic base" description="Is monoprotic base" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="ky6GI8RtoUyjMT14nNjLNg" buildMode="Property" visible="0" canBeVaried="0" />
-              <Parameter id="-j26arafmUCuv76Z4AHYyw" name="Is monoprotic base diprotic acid" description="Is monoprotic base diprotic acid" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="MC6b64t5S0uFTuK7ry0LRg" buildMode="Property" visible="0" canBeVaried="0" />
-              <Parameter id="retZN1skfkmmU71t0IUGRQ" name="CT_NEUTRAL" description="Constant for compound type neutral" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="0" canBeVaried="0" value="0" />
-              <Parameter id="AYfWt72zE0aShQTh3cGP1Q" name="Lipophilicity" description="Model dependent lipophilicity measure: LogMA / LogP / ..." persistable="0" isFixedValue="0" dim="Log Units" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="1" value="3" displayUnit="Log Units" />
-              <Parameter id="Dl8cRvetDEGDhOvriOA8Qw" name="Fraction unbound (plasma, reference value)" description="Fraction unbound in plasma of the reference individual, i.e. in the case of human typically an average healthy adult. This reference value can be scaled to children based on the ontogeny of the respective plasma protein and/or in diseased subjects using the plasma protein scale factor defined in the individual" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="1" value="0.11" />
-              <Parameter id="xL-Tmd9DDUey5e4DIQQIsw" name="Solubility at reference pH" description="Solubility at reference pH" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="1" value="1.2E-05" displayUnit="mg/l" />
-              <Parameter id="sWzhfkA4qUeDIhrADBjFVQ" name="Reference pH" description="Reference pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="1" value="7" />
-              <Parameter id="Y2JnH2j-i0-DxHKklzEGlw" name="Solubility gain per charge" description="Supporting parameter for calculation of pKa- and pH- dependent values of intestinal solubilty" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="0" value="1000" />
-              <Parameter id="09VBh4lYrUyAQhVGx0nEkQ" name="Permeability" description="Permeability" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="vi--TMmPkkeUzIRaAri-ew" buildMode="Property" visible="1" canBeVaried="1" displayUnit="cm/min" />
-              <Parameter id="ve9kBNCZ5UWTYGznt7mZFg" name="Specific intestinal permeability (transcellular)" description="Specific intestinal permeability (transcellular)" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="YdWY6LEFy0eilzVmzYcSrQ" buildMode="Property" visible="1" canBeVaried="1" displayUnit="cm/min" />
-              <Parameter id="8TziOU_OZ0aGPPDePqRwEw" name="Partition coefficient (water/protein)" description="Partition coefficient water to protein" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="SfGHNlQbkUiOXDevaYXKqw" buildMode="Property" visible="1" canBeVaried="1" />
-              <Parameter id="z_3i_pUWh0Wmy6ZwJhO6PQ" name="Treat precipitated drug as" description="Treat precipitated drug as either soluble or insoluble" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="1" value="1" />
-              <Parameter id="bQldcok2lEq9Md6jb9u6Ww" name="Aqueous diffusion coefficient" description="Aqueous diffusion coefficient&#xA;of the drug" persistable="0" isFixedValue="0" dim="Diffusion coefficient" quantityType="Parameter" formula="7qblC70bT0iHuCAviOoS6A" buildMode="Property" visible="1" canBeVaried="1" displayUnit="cm²/min" />
-              <Parameter id="xlCpL7JXQkOy7Mg3Ncxx2g" name="Density (drug)" description="Density of drug material" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="1" value="1" displayUnit="g/cm³" />
-              <Parameter id="vmGA9j5wXU6H9ToIMY9isA" name="Immediately dissolve particles smaller than" description="Threshold for the particle radius of immediate dissolution" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="1" value="1E-07" displayUnit="µm" />
-              <Parameter id="MUJhg6pJMkGRHWNlE29NNg" name="Radius (solute)" description="Solute radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="mglf557pEkW4PikU0-Ku-A" buildMode="Property" visible="1" canBeVaried="1" displayUnit="µm" />
-              <Parameter id="eX_UeuoTNE2heFd2jgL22Q" name="Kd (FcRn) in endosomal space" description="Dissociation constant of drug for binding to FcRn in endosomal space" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="0" value="999999" displayUnit="µmol/l" />
-              <Parameter id="Pexe2lY7cEK5df96McirLw" name="Kd (FcRn) in plasma/interstitial" description="Dissociation constant of drug for binding to FcRn in plasma/interstitial space. For monoclonal antibodies the binding to FcRn in neutral environment (plasma and interstitial space) is generally very weak or not detectable. In this case the high default value for Kd(FcRn) in plasma/interstitial can be kept." persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="0" value="999999" displayUnit="µmol/l" />
-              <Parameter id="691CabgEGEygS9BoRoRpsg" name="kass (FcRn)" description="Association constant of drug for binding to FcRn" persistable="0" isFixedValue="0" dim="Second order rate constant" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="0" value="60" displayUnit="l/µmol/min" />
-              <Parameter id="jn8Z5pk-WEmozw0laLOqbA" name="Use pH- and pKa-dependent penalty factor for charged molecule fraction" description="Penalty factor for charged molecule fraction is used for &quot;Intestinal permeability (transcellular)&quot; only" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="1" value="0" />
-            </Children>
-          </Container>
-          <EventGroup id="Tt_HXMXRakKzJ0heZDKa1A" name="Applications" icon="Applications" mode="Logical" containerType="Other">
-            <Children>
-              <EventGroup id="Q6fnrU36sEWb2oku-bSURA" name="Particles" icon="Formulation" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="jvIWJS_AREqJokOJKvQoIA" name="Thickness (unstirred water layer)" description="Thickness of unstirred water layer" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0002" displayUnit="µm" />
-                  <Parameter id="AdJPCiouCE6V-zVrER1hSw" name="Particle size distribution" description="Particle size distribution" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0" />
-                  <Parameter id="OgPheTOUcE2ek2YJuQQN8Q" name="Type of particle size distribution" description="Type of particle size distribution (monodisperse vs. polydisperse)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0" />
-                  <Parameter id="Vkrw8GNeoUCIAB-SUJj_mw" name="Particle radius (mean)" description="Mean particle radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0001" displayUnit="µm" />
-                  <Parameter id="X3J4FPQOAU2_lLHREdMLcA" name="Particle radius (SD)" description="Standard deviation of particle radius distribution" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="3E-05" displayUnit="µm" />
-                  <Parameter id="tXjaaAy690Cts1-etMJD7Q" name="Particle radius (geomean)" description="Geometric mean of particle radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0001" displayUnit="µm" />
-                  <Parameter id="V3uEpxOwhkay3u56eosiGw" name="Coefficient of variation" description="Coefficient of variation " persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1.5" />
-                  <Parameter id="ryS9KJE_Ek2qw_NLSMkv1g" name="Number of bins" description="Number of bins for particle radius distribution" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="11" />
-                  <Parameter id="oejNDwXaLk2S8HVKvsdQZw" name="Particle radius (min)" description="Lower bound of particle radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="1E-05" displayUnit="µm" />
-                  <Parameter id="0gtSjqF0mky88RWD6MRsUw" name="Particle radius (max)" description="Upper bound of particle radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.00019" displayUnit="µm" />
-                  <EventGroup id="7ArjmgwzEEmpw1aBKdz-_Q" name="Application_1" icon="Oral" mode="Logical" containerType="Other" eventGroupType="Oral">
-                    <Tags>
-                      <Tag value="ParticlesApplication_1_Bins" />
-                      <Tag value="Application" />
-                      <Tag value="Application_1" />
-                      <Tag value="ApplicationRoot" />
-                    </Tags>
-                    <Children>
-                      <Parameter id="-FYLieHBdky6kiIneOLSTQ" name="Tablet time delay factor" description="Tablet time delay factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.2" />
-                      <Parameter id="dBpPYlxgikC1ZZtvTUerXw" name="Tablet_Location_sto" description="Tablet location in Stomach" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="7dHc1Kvd5E-eocQWfKPXJg" visible="0" canBeVaried="0" />
-                      <Parameter id="3gPmlzzzxEGTcETSrwlt5w" name="Tablet_Location_rect" description="Tablet location in Rectum" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="fmN2qqsxFk2VclxZLtP17g" visible="0" canBeVaried="0" />
-                      <Parameter id="JIdSzwd2i0y4gcYYh7LKGA" name="Tablet_Location_uil" description="Tablet location in Upper Ileum" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="4m3NoE9vCEmAwNyp7KnTTA" visible="0" canBeVaried="0" />
-                      <Parameter id="KvJhFMtXgkes6LbsvMxT1Q" name="Tablet_Location_lje" description="Tablet location in Lower Jejunum" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="HjaREld9AUCMQ0VKpOPKeQ" visible="0" canBeVaried="0" />
-                      <Parameter id="PPffe3wKJ0O14em-uZDwOg" name="Tablet_Location_lil" description="Tablet location in Lower Ileum" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="VdxpOVJDDkO24wRq4Vef9w" visible="0" canBeVaried="0" />
-                      <Parameter id="G8ekW7qUu0e-75Xvsa0qTg" name="Tablet_Location_cae" description="Tablet location in Cecum" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CaC1pURvuECHBRnArrMPug" visible="0" canBeVaried="0" />
-                      <Parameter id="kFMSzXh53Eq5ve_e8DyWew" name="Tablet_Location_coltrans" description="Tablet location in Colon Transversum" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="lN5d393rDEKRDU_K2aq6EA" visible="0" canBeVaried="0" />
-                      <Parameter id="mP11DFxLE0SEf1mhJW_7sQ" name="Tablet_Location_colasc" description="Tablet location in Colon Ascendens" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="9ljn6PbEOUy1bfwxfP5zVw" visible="0" canBeVaried="0" />
-                      <Parameter id="QpmJK2PSWUiilRkBheCHgw" name="Tablet_Location_duo" description="Tablet location in Duodenum" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="7CbcUfkiwkKBiATEn1jy0Q" visible="0" canBeVaried="0" />
-                      <Parameter id="57hdERCdjUagp6JC1POPFA" name="Tablet_Location_colsigm" description="Tablet location in Colon Sigmoid" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="HTLMuURWaUy-Is9_13axmA" visible="0" canBeVaried="0" />
-                      <Parameter id="1rZHfsJnx0aQVz7uav5JTQ" name="Tablet_Location_coldesc" description="Tablet location in Colon Descendens" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="RUv1hNQbwU6ST8UCe_UJqw" visible="0" canBeVaried="0" />
-                      <Parameter id="MCrWQEMO9kCxBEPbiMHW-Q" name="Tablet_Location" description="Tablet location in lumen" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="0" rHSFormula="pGh2_eKzOUq5ZCJzSOmU1w" value="1.99" />
-                      <Parameter id="Ze4__aFGnkaNFpmVkMRLWw" name="TabletIsActive" description="Enables/disables all tablet interactions" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="0" value="0" />
-                      <Parameter id="84b7Ml5dXkGLgVh6jLncIw" name="Tablet_Location_uje" description="Tablet location in Upper Jejunum" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CVWZpZrcDkKBPXbSLlkIiQ" visible="0" canBeVaried="0" />
-                      <Event id="ZpKDhP3580uuH8SwZRqDtw" name="Application_StartEvent" description="Start event for application" mode="Logical" containerType="Other" dimension="Dimensionless" formula="4C4y9XqRwUCZ_p3GXWe9bQ" oneTime="1">
-                        <Children>
-                          <EventAssignment id="kA_GKLp42UW9bD-IEL2fkA" name="Assignment_1" dimension="Amount" formula="gilTTxophUWZkDTPj-ZzDg" useAsValue="1" changedEntity="VszokE7WI0SGUR1_-_c-Kw">
-                            <ObjectPath path="5" />
-                          </EventAssignment>
-                          <EventAssignment id="r8vPbdyKNEKl7WkCeEBRHQ" name="Assignment_2" dimension="Dimensionless" formula="V6xzsrMBLUmpfDiG5wEIqw" useAsValue="1" changedEntity="Ze4__aFGnkaNFpmVkMRLWw">
-                            <ObjectPath path="6" />
-                          </EventAssignment>
-                          <EventAssignment id="PKuCi-Gto0GnxZPajpZWjg" name="Assignment_3" dimension="Dimensionless" formula="CI91X9EF0EK0cw0_UYFFMQ" useAsValue="1" changedEntity="2TOFTU6KxkyZgjM29fS9jw">
-                            <ObjectPath path="3" />
-                          </EventAssignment>
-                          <EventAssignment id="pzaGSKe5R0qYpNj6Ps3nYA" name="Assignment_4" dimension="Volume" formula="bVqz9OGN2kO7caswGP81LA" useAsValue="1" changedEntity="8delt8xpp0at7I-zDeOgBg">
-                            <ObjectPath path="0" />
-                          </EventAssignment>
-                        </Children>
-                      </Event>
-                      <Event id="BcBuyjdookqWVXEnoo-_DA" name="Application_StopEvent" description="Stop event for application" mode="Logical" containerType="Other" dimension="Dimensionless" formula="WFOJB_T6VUKxvqPistuwDA" oneTime="1">
-                        <Children>
-                          <EventAssignment id="-jRrFYYp-EaQD4j7MYhmKA" name="Assignment_1" dimension="Dimensionless" formula="U_dm9YBhhEWJjEMpOR0ltw" useAsValue="0" changedEntity="Ze4__aFGnkaNFpmVkMRLWw">
-                            <ObjectPath path="6" />
-                          </EventAssignment>
-                        </Children>
-                      </Event>
-                      <Container id="72b9bywlX0OqKX2YFw_u2g" name="ProtocolSchemaItem" description="Protocol Schema Item" mode="Logical" containerType="Other">
-                        <Tags>
-                          <Tag value="Application" />
-                          <Tag value="Application_1" />
-                        </Tags>
-                        <Children>
-                          <Parameter id="EmZ--yzzCE67OVFCI7-3Rg" name="Start time" description="Start time of application" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" visible="1" canBeVaried="1" value="0" displayUnit="h" />
-                          <Parameter id="J9ogs0AJ6EGV4Pc3pE1acA" name="DosePerBodyWeight" description="Dose" persistable="0" isFixedValue="0" dim="Dose per body weight" quantityType="Parameter" visible="1" canBeVaried="1" value="1E-06" displayUnit="mg/kg" />
-                          <Parameter id="Epv0fkB6UE6vH_33AsOcqg" name="DrugMass" description="Drug mass of application" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" formula="HDbBI1HPIEe9_d0TGTcDdA" visible="0" canBeVaried="1" displayUnit="µmol" />
-                          <Parameter id="LcJJOdD1CUChFG59Y4-0vQ" name="Dose" description="Dose" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="zgtxNdadf0C8CiYnebL-aA" visible="0" canBeVaried="1" displayUnit="mg" />
-                          <Parameter id="wE4BCsOKgEKDdKJdHGGBng" name="Volume of water/body weight" description="Volume of water per body weight co-administered with the drug" persistable="0" isFixedValue="0" dim="Volume per body weight" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0035" displayUnit="ml/kg" />
-                          <Parameter id="SFZ8vXR8_EG2YGQGSxeO0w" name="Amount of water" description="Amount of water" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="U1qDDxPkTkC0dLz3W7AUGQ" visible="0" canBeVaried="1" displayUnit="l" />
-                        </Children>
-                      </Container>
-                      <EventGroup id="YoIzhlb_fkaJBnys951-BQ" name="ParticleBin_1" description="Particle Bin #1" mode="Logical" containerType="Other">
-                        <Tags>
-                          <Tag value="ParticleBin" />
-                          <Tag value="Application" />
-                          <Tag value="Application_1" />
-                        </Tags>
-                        <Children>
-                          <Parameter id="-OHYqvoo9kauHvOZGxKhqQ" name="Number_Of_Particles_Factor" description="Factor for number of particles (depends on particle radius distribution)" persistable="0" isFixedValue="0" dim="Inversed volume" quantityType="Parameter" visible="0" canBeVaried="0" value="238732414637.843" displayUnit="1/l" />
-                          <Parameter id="pElH1EdPqEea7lUHhn26Sg" name="Fraction solid" description="Fraction of solid drug" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" formula="69IHxpkcJ06eNRAwGfCOMQ" visible="0" canBeVaried="0" />
-                          <Parameter id="vmQiR5Pvl0-28VqeZhHVTg" name="Fraction insoluble" description="Fraction of insoluble drug" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" formula="7dFuMWyHAEqLByWfcanYPg" visible="0" canBeVaried="0" />
-                          <Parameter id="IAT5oHrot0OtwmeeqWgItw" name="Fraction dissolved" description="Fraction of dissolved drug" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" formula="mlkz5cnvgkOAKU6R3kIODg" visible="0" canBeVaried="0" />
-                          <Parameter id="DZ-YCunzPk2zTVrBv0nyAw" name="DrugMass of particle bin" description="Drug mass of a single particle bin" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" formula="YfIS5UyBtE2IIcRrCeh80A" visible="0" canBeVaried="1" displayUnit="µmol" />
-                          <Parameter id="4AwL0HdGLk6mzKlLz9YBLA" name="Number of particles" description="Number of drug particles in one particle bin" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="z2J6dWxta0iiGDkEd_S2aA" visible="1" canBeVaried="1" />
-                          <Parameter id="lRQ74rNDmEixJSvYH2K9Dg" name="Particle radius (at t=0)" description="Particle radius at t=0" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0001" displayUnit="µm" />
-                          <Parameter id="QhZHwKrA_k2m_0n_uWN6Ew" name="Particle radius" description="Particle radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="0" value="0" displayUnit="µm" />
-                          <Event id="4sF11y6_WkeeirPkq-ezEw" name="ParticleBinDissolvedEvent" description="ParticleBinDissolvedEvent" mode="Logical" containerType="Other" dimension="Dimensionless" formula="0mq5QPRtfkeXCvOEzwQHiQ" oneTime="1">
-                            <Children>
-                              <EventAssignment id="x6Q2lnaKIEKw4lhJ1bcS1A" name="Assignment_1" dimension="Amount" formula="qdDQ225oZUGWetmSxuULXA" useAsValue="1" changedEntity="Qnj6YM6q_kSvSvGmWycE8g">
-                                <ObjectPath path="7" />
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-                              <EventAssignment id="Vre4DoBbFEi7wl3zFDeIVg" name="Assignment_2" dimension="Amount" formula="ujf29U82iUGEOHOj9U_olA" useAsValue="1" changedEntity="mgzsCzTwXkGLoEv-ZBAnNQ">
-                                <ObjectPath path="8" />
-                              </EventAssignment>
-                              <EventAssignment id="dRmvXsGkh0GzxeqTDOHc0g" name="Assignment_3" dimension="Amount" formula="UCihUDTvPUeDtOf0DHgXoQ" useAsValue="1" changedEntity="yiZ323gtz0WRt_37u8tDPQ">
-                                <ObjectPath path="9" />
-                              </EventAssignment>
-                              <EventAssignment id="5cO1NE8S3ECwhCIxrnKVKg" name="Assignment_4" dimension="Amount" formula="s69aiGv2j0GcXdkvL2x0tQ" useAsValue="1" changedEntity="jIGCgtwn-U2Oqcv2W4G-ZQ">
-                                <ObjectPath path="10" />
-                              </EventAssignment>
-                              <EventAssignment id="iAMTtVYwSEubu_OMDgHWaw" name="Assignment_5" dimension="Amount" formula="zK8sQNqfo0SmsxOQVBrqFQ" useAsValue="1" changedEntity="B3i4ajvEPkWwF-QJhPT-RA">
-                                <ObjectPath path="11" />
-                              </EventAssignment>
-                              <EventAssignment id="_5G4vuZ9ckeBER09YFlEgg" name="Assignment_6" dimension="Amount" formula="H3G1HmtyZE2sNyn_2BPQ2g" useAsValue="1" changedEntity="BaeHcf6VhUyw3ftOPt1iIg">
-                                <ObjectPath path="12" />
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-                              <EventAssignment id="VTQXG1rJl0y28MVR5HhVsQ" name="Assignment_7" dimension="Amount" formula="DtDDG--aY0erWl5Uaqe3fg" useAsValue="1" changedEntity="yw7rzbgJB0-l91_K8hz0sQ">
-                                <ObjectPath path="13" />
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-                              <EventAssignment id="mhUkcksyeE6iC21KdXMcBg" name="Assignment_8" dimension="Amount" formula="Q1sfQzrvpkaDRJW2YsCxTw" useAsValue="1" changedEntity="Cuam5DbmZ0uqXwc9apFicg">
-                                <ObjectPath path="14" />
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-                              <EventAssignment id="-rf3XcWRTkO3NB_GNJKjOQ" name="Assignment_9" dimension="Amount" formula="yjJYxfWaCEeiBHAju5ieFQ" useAsValue="1" changedEntity="2kdpKYdY3EeBvJPRNS1TEg">
-                                <ObjectPath path="15" />
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-                              <EventAssignment id="93FK2SudkkaI0MQdIHWm9g" name="Assignment_10" dimension="Amount" formula="3PoD-SMsPkynzN0rdtRsGQ" useAsValue="1" changedEntity="r-aj2d-zBEqErgcKF5e5cw">
-                                <ObjectPath path="16" />
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-                              <EventAssignment id="bUj4FPinQUScuspSmHOmtw" name="Assignment_11" dimension="Amount" formula="ba2bazbLTEyyjXgsdQ9Kpg" useAsValue="1" changedEntity="xrlOSQNSBk-WGtZ7E-tEYw">
-                                <ObjectPath path="17" />
-                              </EventAssignment>
-                              <EventAssignment id="kaYT0F3H2U6tV2wqncNuOw" name="Assignment_12" dimension="Amount" formula="pHJ_EnTTzEeB1HQlLwGb7Q" useAsValue="1" changedEntity="V3v2rXqlRkujCVZ10rY3Ew">
-                                <ObjectPath path="18" />
-                              </EventAssignment>
-                              <EventAssignment id="pVKCs57Bx02oztNqq1qu8Q" name="Assignment_13" dimension="Dimensionless" formula="1i5wXRpt6UKJZh6A7fIBFw" useAsValue="1" changedEntity="qDHwaA9ork6sAO1_XZF3XA">
-                                <ObjectPath path="19" />
-                              </EventAssignment>
-                            </Children>
-                          </Event>
-                          <Container id="_B99udIih0GjHfLBejwghg" name="InsolubleDrug" description="Insoluble Drug during particle dissolution" mode="Logical" containerType="Other">
-                            <Tags>
-                              <Tag value="InsolubleDrug" />
-                              <Tag value="Application" />
-                              <Tag value="Application_1" />
-                            </Tags>
-                            <Children>
-                              <MoleculeAmount id="Cl1DWJlu4E6bdjBOMOGfYQ" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" formula="Q_C8Zi7YPkKusiBZh2GpTQ" mode="Logical" scaleFactor="1" displayUnit="µmol">
-                                <Children>
-                                  <Parameter id="FEPbFL75FUyLVORfVqBI4Q" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                                  <Transport id="B5kePIXEkUyCF3b5IecgKg" name="ParticlesPrecipitationCaecum" description="Particles precipitation in Cecum" mode="Logical" containerType="Transport" dimension="Amount per time" formula="1VGEpHrXOE2lrcAvRiBqTQ" sourceAmount="Cl1DWJlu4E6bdjBOMOGfYQ" targetAmount="Qnj6YM6q_kSvSvGmWycE8g">
-                                    <Children>
-                                      <Parameter id="CLqJ-VAEbEugAS2BpGfBDA" name="Precipitation rate of the tablet" description="Precipitation rate of the tablet" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="LW98m6gCCU2qzB0kZ_3PtQ" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                                    </Children>
-                                  </Transport>
-                                  <Transport id="2WYhbcGi3UivvJvRrqxLEA" name="ParticlesPrecipitationColonAscendens" description="Particles precipitation in ColonAscendens" mode="Logical" containerType="Transport" dimension="Amount per time" formula="ki0QI1T8JECMHgfdgfZuiA" sourceAmount="Cl1DWJlu4E6bdjBOMOGfYQ" targetAmount="mgzsCzTwXkGLoEv-ZBAnNQ">
-                                    <Children>
-                                      <Parameter id="U40cONLEuEOcP1paUgwPOA" name="Precipitation rate of the tablet" description="Precipitation rate of the tablet" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="icNAdc6PvE2Vm0cY9irb9w" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                                    </Children>
-                                  </Transport>
-                                  <Transport id="O73kK392VkGF-nDqXgvrRQ" name="ParticlesPrecipitationColonDescendens" description="Particles precipitation in ColonDescendens" mode="Logical" containerType="Transport" dimension="Amount per time" formula="pbhfy9r9zkih9PB8CrqxsQ" sourceAmount="Cl1DWJlu4E6bdjBOMOGfYQ" targetAmount="yiZ323gtz0WRt_37u8tDPQ">
-                                    <Children>
-                                      <Parameter id="ipARTe8C_0SpQ_x2eqaGyQ" name="Precipitation rate of the tablet" description="Precipitation rate of the tablet" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="0UuF8eufMkOx4eNUP-DcFA" visible="0" canBeVaried="0" displayUnit="µmol/min" />
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-          <Map s="S1|Organism|Skin|Plasma|C1|Concentration" id="174" />
-          <Map s="C_pls_skn" id="175" />
-          <Map s="S1|C1|Fraction unbound (plasma)" id="176" />
-          <Map s="fu" id="177" />
-          <Map s="..|Density (tissue)" id="178" />
-          <Map s="Density" id="179" />
-          <Map s="..|Volume" id="180" />
-          <Map s="..|..|Fraction vascular" id="181" />
-          <Map s="f_vas" id="182" />
-          <Map s="..|..|Volume" id="183" />
-          <Map s="V" id="184" />
-          <Map s=".." id="185" />
-          <Map s="M" id="186" />
-          <Map s="Amount" id="187" />
-          <Map s="..|Concentration" id="188" />
-          <Map s="C_pls" id="189" />
-          <Map s="S1|C1|Partition coefficient (blood cells/plasma)" id="190" />
-          <Map s="K_rbc" id="191" />
-          <Map s="..|..|BloodCells|C1|Concentration" id="192" />
-          <Map s="C_bc" id="193" />
-          <Map s="..|..|Plasma|C1|Concentration" id="194" />
-          <Map s="..|Gallbladder ejection half-time" id="195" />
-          <Map s="EHC_HalfTime" id="196" />
-          <Map s="Time" id="197" />
-          <Map s="S1|Applications|TotalDrugMass" id="198" />
-          <Map s="TotalDrugMass" id="199" />
-          <Map s="..|Specific blood flow rate" id="200" />
-          <Map s="Qspec" id="201" />
-          <Map s="Flow per weight organ" id="202" />
-          <Map s="..|Weight (tissue)" id="203" />
-          <Map s="Weight" id="204" />
-          <Map s="S1|Organism|Thickness (endothelium)" id="205" />
-          <Map s="d_endo" id="206" />
-          <Map s="S1|Neighborhoods|Bone_pls_Bone_int|Surface area (plasma/interstitial)" id="207" />
-          <Map s="SA_pls_int" id="208" />
-          <Map s="Area" id="209" />
-          <Map s="..|Fraction interstitial" id="210" />
-          <Map s="f_int" id="211" />
-          <Map s="..|Fraction vascular" id="212" />
-          <Map s="V_org" id="213" />
-          <Map s="..|..|Fraction interstitial" id="214" />
-          <Map s="S1|Organism|pH (interstitial)" id="215" />
-          <Map s="pH_int" id="216" />
-          <Map s="S1|Neighborhoods|Bone_int_Bone_cell|C1|Partition coefficient (interstitial/water)" id="217" />
-          <Map s="K_water_int" id="218" />
-          <Map s="..|..|Fraction intracellular" id="219" />
-          <Map s="f_cell" id="220" />
-          <Map s="S1|Neighborhoods|Bone_int_Bone_cell|C1|Partition coefficient (intracellular/water)" id="221" />
-          <Map s="K_water_cell" id="222" />
-          <Map s="..|..|Interstitial|C1|Concentration" id="223" />
-          <Map s="C_int" id="224" />
-          <Map s="..|..|Interstitial|C1|Partition coefficient (water/container)" id="225" />
-          <Map s="..|..|Intracellular|C1|Concentration" id="226" />
-          <Map s="C_cell" id="227" />
-          <Map s="..|..|Intracellular|C1|Partition coefficient (water/container)" id="228" />
-          <Map s="S1|Neighborhoods|Brain_pls_Brain_int|Surface area (plasma/interstitial)" id="229" />
-          <Map s="S1|Neighborhoods|Brain_int_Brain_cell|C1|Partition coefficient (interstitial/water)" id="230" />
-          <Map s="S1|Neighborhoods|Brain_int_Brain_cell|C1|Partition coefficient (intracellular/water)" id="231" />
-          <Map s="S1|Neighborhoods|Fat_pls_Fat_int|Surface area (plasma/interstitial)" id="232" />
-          <Map s="GeometricDeviation" id="233" />
-          <Map s="S1|Neighborhoods|Fat_int_Fat_cell|C1|Partition coefficient (interstitial/water)" id="234" />
-          <Map s="S1|Neighborhoods|Fat_int_Fat_cell|C1|Partition coefficient (intracellular/water)" id="235" />
-          <Map s="S1|Neighborhoods|Gonads_pls_Gonads_int|Surface area (plasma/interstitial)" id="236" />
-          <Map s="S1|Neighborhoods|Gonads_int_Gonads_cell|C1|Partition coefficient (interstitial/water)" id="237" />
-          <Map s="S1|Neighborhoods|Gonads_int_Gonads_cell|C1|Partition coefficient (intracellular/water)" id="238" />
-          <Map s="S1|Neighborhoods|Heart_pls_Heart_int|Surface area (plasma/interstitial)" id="239" />
-          <Map s="S1|Neighborhoods|Heart_int_Heart_cell|C1|Partition coefficient (interstitial/water)" id="240" />
-          <Map s="S1|Neighborhoods|Heart_int_Heart_cell|C1|Partition coefficient (intracellular/water)" id="241" />
-          <Map s="S1|Neighborhoods|Kidney_pls_Kidney_int|Surface area (plasma/interstitial)" id="242" />
-          <Map s="S1|Organism|Estimated gestational age" id="243" />
-          <Map s="PMA" id="244" />
-          <Map s="S1|Organism|Kidney|fGFRpremat" id="245" />
-          <Map s="GFR_premat" id="246" />
-          <Map s="S1|Organism|Kidney|GFRmat" id="247" />
-          <Map s="GFR_mat" id="248" />
-          <Map s="Flow" id="249" />
-          <Map s="S1|Organism|Kidney|Hill coefficient for GFR" id="250" />
-          <Map s="Hill" id="251" />
-          <Map s="S1|Organism|Kidney|TM50 for GFR" id="252" />
-          <Map s="TM50" id="253" />
-          <Map s="S1|Organism|Kidney|Volume (standard kidney)" id="254" />
-          <Map s="V_kid_std" id="255" />
-          <Map s="S1|Neighborhoods|Kidney_int_Kidney_cell|C1|Partition coefficient (interstitial/water)" id="256" />
-          <Map s="S1|Neighborhoods|Kidney_int_Kidney_cell|C1|Partition coefficient (intracellular/water)" id="257" />
-          <Map s="..|Distal radius" id="258" />
-          <Map s="r2" id="259" />
-          <Map s="..|Length" id="260" />
-          <Map s="L" id="261" />
-          <Map s="..|Proximal radius" id="262" />
-          <Map s="r1" id="263" />
-          <Map s="..|Geometric surface area" id="264" />
-          <Map s="..|Thickness of gut wall" id="265" />
-          <Map s="d" id="266" />
-          <Map s="..|pH in fasted state" id="267" />
-          <Map s="pH_fasted" id="268" />
-          <Map s="..|Fractional steady state fill level" id="269" />
-          <Map s="SteadyStateFillLevel" id="270" />
-          <Map s="..|Inverse rate of inflow of liquid into stomach" id="271" />
-          <Map s="StomachInflowTime" id="272" />
-          <Map s="..|Fraction of geometric volume filled with liquid" id="273" />
-          <Map s="FillLevel" id="274" />
-          <Map s="..|Liquid" id="275" />
-          <Map s="Liquid" id="276" />
-          <Map s="..|Gastric emptying time" id="277" />
-          <Map s="GET" id="278" />
-          <Map s="..|FillLevelFlag" id="279" />
-          <Map s="FillLevelFlag" id="280" />
-          <Map s="..|Liquid transfer rate" id="281" />
-          <Map s="LT_sto" id="282" />
-          <Map s="..|Secretion of liquid" id="283" />
-          <Map s="Inflow" id="284" />
-          <Map s="..|..|OralApplicationsEnabled" id="285" />
-          <Map s="OralApplicationsEnabled" id="286" />
-          <Map s="..|Intestinal transit rate (absolute)" id="287" />
-          <Map s="w" id="288" />
-          <Map s="..|..|Duodenum|FillLevelFlag" id="289" />
-          <Map s="FillLevelFlagNext" id="290" />
-          <Map s="..|pKa_pH_WS_lum_F1" id="291" />
-          <Map s="F1" id="292" />
-          <Map s="..|pKa_pH_WS_lum_F2" id="293" />
-          <Map s="F2" id="294" />
-          <Map s="..|pKa_pH_WS_lum_F3" id="295" />
-          <Map s="F3" id="296" />
-          <Map s="S1|C1|Compound type 2" id="297" />
-          <Map s="CT2" id="298" />
-          <Map s="S1|C1|CT_NEUTRAL" id="299" />
-          <Map s="CT_NEUTRAL" id="300" />
-          <Map s="S1|C1|pKa value 2" id="301" />
-          <Map s="pKa_2" id="302" />
-          <Map s="..|..|pH" id="303" />
-          <Map s="pH" id="304" />
-          <Map s="S1|C1|Compound type 1" id="305" />
-          <Map s="CT1" id="306" />
-          <Map s="S1|C1|pKa value 1" id="307" />
-          <Map s="pKa_1" id="308" />
-          <Map s="S1|C1|Compound type 0" id="309" />
-          <Map s="CT0" id="310" />
-          <Map s="S1|C1|pKa value 0" id="311" />
-          <Map s="pKa_0" id="312" />
-          <Map s="..|pKa_pH_WS_lum_K1" id="313" />
-          <Map s="K1" id="314" />
-          <Map s="..|pKa_pH_WS_lum_K2" id="315" />
-          <Map s="K2" id="316" />
-          <Map s="..|pKa_pH_WS_lum_K3" id="317" />
-          <Map s="K3" id="318" />
-          <Map s="..|pKa_pH_WS_lum_K4" id="319" />
-          <Map s="K4" id="320" />
-          <Map s="..|pKa_pH_WS_lum_K5" id="321" />
-          <Map s="K5" id="322" />
-          <Map s="..|pKa_pH_WS_lum_K6" id="323" />
-          <Map s="K6" id="324" />
-          <Map s="..|pKa_pH_WS_lum_K7" id="325" />
-          <Map s="K7" id="326" />
-          <Map s="..|pKa_pH_WS_lum_K8" id="327" />
-          <Map s="K8" id="328" />
-          <Map s="S1|C1|Solubility gain per charge" id="329" />
-          <Map s="base" id="330" />
-          <Map s="..|Solubility_pKa_pH_Factor" id="331" />
-          <Map s="Solubility_pKa_pH_Factor" id="332" />
-          <Map s="S1|C1|Solubility at reference pH" id="333" />
-          <Map s="Solubility" id="334" />
-          <Map s="Concentration (mass)" id="335" />
-          <Map s="S1|C1|Solubility_pKa_pH_Factor" id="336" />
-          <Map s="Solubility_pKa_REFpH_Factor" id="337" />
-          <Map s="..|..|Liquid" id="338" />
-          <Map s="..|..|..|Height" id="339" />
-          <Map s="..|r1_p0" id="340" />
-          <Map s="r1_p0" id="341" />
-          <Map s="..|r1_p1" id="342" />
-          <Map s="r1_p1" id="343" />
-          <Map s="alpha" id="344" />
-          <Map s="k" id="345" />
-          <Map s="inflow" id="346" />
-          <Map s="..|..|Stomach|Fractional steady state fill level" id="347" />
-          <Map s="alpha_p" id="348" />
-          <Map s="..|..|Stomach|Intestinal transit rate (absolute)" id="349" />
-          <Map s="k_p" id="350" />
-          <Map s="..|..|Stomach|Volume" id="351" />
-          <Map s="V_p" id="352" />
-          <Map s="..|r2_p0" id="353" />
-          <Map s="r2_p0" id="354" />
-          <Map s="..|r2_p1" id="355" />
-          <Map s="r2_p1" id="356" />
-          <Map s="..|Intestinal transit rate" id="357" />
-          <Map s="LuminalVelocity" id="358" />
-          <Map s="S1|Organism|SmallIntestine|Small intestinal transit time factor" id="359" />
-          <Map s="SITT_fact" id="360" />
-          <Map s="..|L_p0" id="361" />
-          <Map s="L_p0" id="362" />
-          <Map s="..|L_p1" id="363" />
-          <Map s="L_p1" id="364" />
-          <Map s="..|..|UpperJejunum|FillLevelFlag" id="365" />
-          <Map s="..|Thickness_p1" id="366" />
-          <Map s="Thickness_p1" id="367" />
-          <Map s="..|Thickness_p2" id="368" />
-          <Map s="Thickness_p2" id="369" />
-          <Map s="..|Thickness_p3" id="370" />
-          <Map s="Thickness_p3" id="371" />
-          <Map s="Inversed length" id="372" />
-          <Map s="V_Intestine" id="373" />
-          <Map s="..|Absorption of liquid" id="374" />
-          <Map s="Outflow" id="375" />
-          <Map s="LT_duo" id="376" />
-          <Map s="..|..|Stomach|Liquid transfer rate" id="377" />
-          <Map s="S1|Neighborhoods|Lumen_duo_Duodenum_pls|C1|Sum of active process rates" id="378" />
-          <Map s="ActiveRates_para" id="379" />
-          <Map s="Amount per time" id="380" />
-          <Map s="S1|Neighborhoods|Lumen_duo_Duodenum_cell|C1|Sum of active process rates" id="381" />
-          <Map s="ActiveRates_trans" id="382" />
-          <Map s="S1|Neighborhoods|Lumen_duo_Duodenum_pls|C1|Sum of passive process rates" id="383" />
-          <Map s="PassiveRates_para" id="384" />
-          <Map s="S1|Neighborhoods|Lumen_duo_Duodenum_cell|C1|Sum of passive process rates" id="385" />
-          <Map s="PassiveRates_trans" id="386" />
-          <Map s="..|Oral mass absorbed segment" id="387" />
-          <Map s="MassAbsorbed" id="388" />
-          <Map s="OralDrugMass" id="389" />
-          <Map s="..|..|LowerJejunum|FillLevelFlag" id="390" />
-          <Map s="LT_uje" id="391" />
-          <Map s="..|..|Duodenum|Liquid transfer rate" id="392" />
-          <Map s="..|..|Duodenum|Fractional steady state fill level" id="393" />
-          <Map s="..|..|Duodenum|Intestinal transit rate (absolute)" id="394" />
-          <Map s="..|..|Duodenum|Volume" id="395" />
-          <Map s="S1|Neighborhoods|Lumen_uje_UpperJejunum_pls|C1|Sum of active process rates" id="396" />
-          <Map s="S1|Neighborhoods|Lumen_uje_UpperJejunum_cell|C1|Sum of active process rates" id="397" />
-          <Map s="S1|Neighborhoods|Lumen_uje_UpperJejunum_pls|C1|Sum of passive process rates" id="398" />
-          <Map s="S1|Neighborhoods|Lumen_uje_UpperJejunum_cell|C1|Sum of passive process rates" id="399" />
-          <Map s="..|..|UpperJejunum|Fractional steady state fill level" id="400" />
-          <Map s="..|..|UpperJejunum|Intestinal transit rate (absolute)" id="401" />
-          <Map s="..|..|UpperJejunum|Volume" id="402" />
-          <Map s="LT_lje" id="403" />
-          <Map s="..|..|UpperJejunum|Liquid transfer rate" id="404" />
-          <Map s="..|..|UpperIleum|FillLevelFlag" id="405" />
-          <Map s="S1|Neighborhoods|Lumen_lje_LowerJejunum_pls|C1|Sum of active process rates" id="406" />
-          <Map s="S1|Neighborhoods|Lumen_lje_LowerJejunum_cell|C1|Sum of active process rates" id="407" />
-          <Map s="S1|Neighborhoods|Lumen_lje_LowerJejunum_pls|C1|Sum of passive process rates" id="408" />
-          <Map s="S1|Neighborhoods|Lumen_lje_LowerJejunum_cell|C1|Sum of passive process rates" id="409" />
-          <Map s="..|..|LowerJejunum|Fractional steady state fill level" id="410" />
-          <Map s="..|..|LowerJejunum|Intestinal transit rate (absolute)" id="411" />
-          <Map s="..|..|LowerJejunum|Volume" id="412" />
-          <Map s="LT_uil" id="413" />
-          <Map s="..|..|LowerJejunum|Liquid transfer rate" id="414" />
-          <Map s="..|..|LowerIleum|FillLevelFlag" id="415" />
-          <Map s="S1|Neighborhoods|Lumen_uil_UpperIleum_pls|C1|Sum of active process rates" id="416" />
-          <Map s="S1|Neighborhoods|Lumen_uil_UpperIleum_cell|C1|Sum of active process rates" id="417" />
-          <Map s="S1|Neighborhoods|Lumen_uil_UpperIleum_pls|C1|Sum of passive process rates" id="418" />
-          <Map s="S1|Neighborhoods|Lumen_uil_UpperIleum_cell|C1|Sum of passive process rates" id="419" />
-          <Map s="..|..|UpperIleum|Fractional steady state fill level" id="420" />
-          <Map s="..|..|UpperIleum|Intestinal transit rate (absolute)" id="421" />
-          <Map s="..|..|UpperIleum|Volume" id="422" />
-          <Map s="LT_lil" id="423" />
-          <Map s="..|..|UpperIleum|Liquid transfer rate" id="424" />
-          <Map s="..|..|Caecum|FillLevelFlag" id="425" />
-          <Map s="S1|Neighborhoods|Lumen_lil_LowerIleum_pls|C1|Sum of active process rates" id="426" />
-          <Map s="S1|Neighborhoods|Lumen_lil_LowerIleum_cell|C1|Sum of active process rates" id="427" />
-          <Map s="S1|Neighborhoods|Lumen_lil_LowerIleum_pls|C1|Sum of passive process rates" id="428" />
-          <Map s="S1|Neighborhoods|Lumen_lil_LowerIleum_cell|C1|Sum of passive process rates" id="429" />
-          <Map s="..|..|LowerIleum|Fractional steady state fill level" id="430" />
-          <Map s="..|..|LowerIleum|Intestinal transit rate (absolute)" id="431" />
-          <Map s="..|..|LowerIleum|Volume" id="432" />
-          <Map s="S1|Organism|LargeIntestine|Large intestinal transit time factor" id="433" />
-          <Map s="LITT_fact" id="434" />
-          <Map s="LT_cae" id="435" />
-          <Map s="..|..|LowerIleum|Liquid transfer rate" id="436" />
-          <Map s="..|..|ColonAscendens|FillLevelFlag" id="437" />
-          <Map s="S1|Neighborhoods|Lumen_cae_Caecum_pls|C1|Sum of active process rates" id="438" />
-          <Map s="S1|Neighborhoods|Lumen_cae_Caecum_cell|C1|Sum of active process rates" id="439" />
-          <Map s="S1|Neighborhoods|Lumen_cae_Caecum_pls|C1|Sum of passive process rates" id="440" />
-          <Map s="S1|Neighborhoods|Lumen_cae_Caecum_cell|C1|Sum of passive process rates" id="441" />
-          <Map s="..|..|Caecum|Fractional steady state fill level" id="442" />
-          <Map s="..|..|Caecum|Intestinal transit rate (absolute)" id="443" />
-          <Map s="..|..|Caecum|Volume" id="444" />
-          <Map s="LT_colasc" id="445" />
-          <Map s="..|..|Caecum|Liquid transfer rate" id="446" />
-          <Map s="..|..|ColonTransversum|FillLevelFlag" id="447" />
-          <Map s="S1|Neighborhoods|Lumen_colasc_ColonAscendens_pls|C1|Sum of active process rates" id="448" />
-          <Map s="S1|Neighborhoods|Lumen_colasc_ColonAscendens_cell|C1|Sum of active process rates" id="449" />
-          <Map s="S1|Neighborhoods|Lumen_colasc_ColonAscendens_pls|C1|Sum of passive process rates" id="450" />
-          <Map s="S1|Neighborhoods|Lumen_colasc_ColonAscendens_cell|C1|Sum of passive process rates" id="451" />
-          <Map s="..|..|ColonDescendens|FillLevelFlag" id="452" />
-          <Map s="LT_coltrans" id="453" />
-          <Map s="..|..|ColonAscendens|Liquid transfer rate" id="454" />
-          <Map s="..|..|ColonAscendens|Fractional steady state fill level" id="455" />
-          <Map s="..|..|ColonAscendens|Intestinal transit rate (absolute)" id="456" />
-          <Map s="..|..|ColonAscendens|Volume" id="457" />
-          <Map s="S1|Neighborhoods|Lumen_coltrans_ColonTransversum_pls|C1|Sum of active process rates" id="458" />
-          <Map s="S1|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|C1|Sum of active process rates" id="459" />
-          <Map s="S1|Neighborhoods|Lumen_coltrans_ColonTransversum_pls|C1|Sum of passive process rates" id="460" />
-          <Map s="S1|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|C1|Sum of passive process rates" id="461" />
-          <Map s="LT_coldesc" id="462" />
-          <Map s="..|..|ColonTransversum|Liquid transfer rate" id="463" />
-          <Map s="..|..|ColonSigmoid|FillLevelFlag" id="464" />
-          <Map s="..|..|ColonTransversum|Fractional steady state fill level" id="465" />
-          <Map s="..|..|ColonTransversum|Intestinal transit rate (absolute)" id="466" />
-          <Map s="..|..|ColonTransversum|Volume" id="467" />
-          <Map s="S1|Neighborhoods|Lumen_coldesc_ColonDescendens_pls|C1|Sum of active process rates" id="468" />
-          <Map s="S1|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|C1|Sum of active process rates" id="469" />
-          <Map s="S1|Neighborhoods|Lumen_coldesc_ColonDescendens_pls|C1|Sum of passive process rates" id="470" />
-          <Map s="S1|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|C1|Sum of passive process rates" id="471" />
-          <Map s="..|..|ColonDescendens|Fractional steady state fill level" id="472" />
-          <Map s="..|..|ColonDescendens|Intestinal transit rate (absolute)" id="473" />
-          <Map s="..|..|ColonDescendens|Volume" id="474" />
-          <Map s="LT_colsigm" id="475" />
-          <Map s="..|..|ColonDescendens|Liquid transfer rate" id="476" />
-          <Map s="..|..|Rectum|FillLevelFlag" id="477" />
-          <Map s="S1|Neighborhoods|Lumen_colsigm_ColonSigmoid_pls|C1|Sum of active process rates" id="478" />
-          <Map s="S1|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|C1|Sum of active process rates" id="479" />
-          <Map s="S1|Neighborhoods|Lumen_colsigm_ColonSigmoid_pls|C1|Sum of passive process rates" id="480" />
-          <Map s="S1|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|C1|Sum of passive process rates" id="481" />
-          <Map s="..|..|ColonSigmoid|Fractional steady state fill level" id="482" />
-          <Map s="..|..|ColonSigmoid|Intestinal transit rate (absolute)" id="483" />
-          <Map s="..|..|ColonSigmoid|Volume" id="484" />
-          <Map s="LT_rect" id="485" />
-          <Map s="..|..|ColonSigmoid|Liquid transfer rate" id="486" />
-          <Map s="S1|Neighborhoods|Lumen_rect_Rectum_pls|C1|Sum of active process rates" id="487" />
-          <Map s="S1|Neighborhoods|Lumen_rect_Rectum_cell|C1|Sum of active process rates" id="488" />
-          <Map s="S1|Neighborhoods|Lumen_rect_Rectum_pls|C1|Sum of passive process rates" id="489" />
-          <Map s="S1|Neighborhoods|Lumen_rect_Rectum_cell|C1|Sum of passive process rates" id="490" />
-          <Map s="M_cae" id="491" />
-          <Map s="M_colasc" id="492" />
-          <Map s="M_coldesc" id="493" />
-          <Map s="M_colsigm" id="494" />
-          <Map s="M_coltrans" id="495" />
-          <Map s="M_duo" id="496" />
-          <Map s="S1|Organism|Lumen|Feces|C1" id="497" />
-          <Map s="M_fec" id="498" />
-          <Map s="M_lil" id="499" />
-          <Map s="M_lje" id="500" />
-          <Map s="M_rect" id="501" />
-          <Map s="M_uil" id="502" />
-          <Map s="M_uje" id="503" />
-          <Map s="S1|Neighborhoods|Lumen_sto_Lumen_duo|C1|Oral mass absorbed" id="504" />
-          <Map s="Mabs_Mucosa" id="505" />
-          <Map s="TotalOralDrugMass" id="506" />
-          <Map s="..|..|Rectum|Liquid transfer rate" id="507" />
-          <Map s="LT_rec" id="508" />
-          <Map s="S1|Neighborhoods|Stomach_pls_Stomach_int|Surface area (plasma/interstitial)" id="509" />
-          <Map s="S1|Neighborhoods|Stomach_int_Stomach_cell|C1|Partition coefficient (interstitial/water)" id="510" />
-          <Map s="S1|Neighborhoods|Stomach_int_Stomach_cell|C1|Partition coefficient (intracellular/water)" id="511" />
-          <Map s="..|Small intestinal transit time" id="512" />
-          <Map s="SITT" id="513" />
-          <Map s="..|Small intestinal transit time factor intercept" id="514" />
-          <Map s="P2" id="515" />
-          <Map s="..|Small intestinal transit time factor slope" id="516" />
-          <Map s="P1" id="517" />
-          <Map s="..|Lymph flow rate (incl. mucosa)" id="518" />
-          <Map s="Q_lymph_incl_Mucosa" id="519" />
-          <Map s="..|Mucosa|Duodenum|Lymph flow rate" id="520" />
-          <Map s="Q_lymph_duo" id="521" />
-          <Map s="..|Mucosa|LowerIleum|Lymph flow rate" id="522" />
-          <Map s="Q_lymph_lil" id="523" />
-          <Map s="..|Mucosa|LowerJejunum|Lymph flow rate" id="524" />
-          <Map s="Q_lymph_lje" id="525" />
-          <Map s="..|Mucosa|UpperIleum|Lymph flow rate" id="526" />
-          <Map s="Q_lymph_uil" id="527" />
-          <Map s="..|Mucosa|UpperJejunum|Lymph flow rate" id="528" />
-          <Map s="Q_lymph_uje" id="529" />
-          <Map s="S1|Neighborhoods|SmallIntestine_pls_SmallIntestine_int|Surface area (plasma/interstitial)" id="530" />
-          <Map s="..|Fluid recirculation flow rate (incl. mucosa)" id="531" />
-          <Map s="J_iso_incl_Mucosa" id="532" />
-          <Map s="..|Mucosa|Duodenum|Fluid recirculation flow rate" id="533" />
-          <Map s="J_iso_duo" id="534" />
-          <Map s="..|Mucosa|LowerIleum|Fluid recirculation flow rate" id="535" />
-          <Map s="J_iso_lil" id="536" />
-          <Map s="..|Mucosa|LowerJejunum|Fluid recirculation flow rate" id="537" />
-          <Map s="J_iso_lje" id="538" />
-          <Map s="..|Mucosa|UpperIleum|Fluid recirculation flow rate" id="539" />
-          <Map s="J_iso_uil" id="540" />
-          <Map s="..|Mucosa|UpperJejunum|Fluid recirculation flow rate" id="541" />
-          <Map s="J_iso_uje" id="542" />
-          <Map s="..|Mucosa|Duodenum|Volume" id="543" />
-          <Map s="V_duo" id="544" />
-          <Map s="..|Mucosa|LowerIleum|Volume" id="545" />
-          <Map s="V_lil" id="546" />
-          <Map s="..|Mucosa|LowerJejunum|Volume" id="547" />
-          <Map s="V_lje" id="548" />
-          <Map s="..|Mucosa|UpperIleum|Volume" id="549" />
-          <Map s="V_uil" id="550" />
-          <Map s="..|Mucosa|UpperJejunum|Volume" id="551" />
-          <Map s="V_uje" id="552" />
-          <Map s="..|..|Volume (mucosa)" id="553" />
-          <Map s="V_Mucosa" id="554" />
-          <Map s="S1|Neighborhoods|SmallIntestine_int_SmallIntestine_cell|C1|Partition coefficient (interstitial/water)" id="555" />
-          <Map s="S1|Neighborhoods|SmallIntestine_int_SmallIntestine_cell|C1|Partition coefficient (intracellular/water)" id="556" />
-          <Map s="..|Fraction mucosa" id="557" />
-          <Map s="fractionMucosa" id="558" />
-          <Map s="..|..|..|..|Lumen|Duodenum|Volume (gut wall)" id="559" />
-          <Map s="V_GutWall" id="560" />
-          <Map s="S1|Neighborhoods|Duodenum_pls_Duodenum_int|Surface area (plasma/interstitial)" id="561" />
-          <Map s="..|..|..|Lymph flow rate (incl. mucosa)" id="562" />
-          <Map s="Q_lymph_intestine" id="563" />
-          <Map s="..|..|..|Volume" id="564" />
-          <Map s="V_intestine" id="565" />
-          <Map s="V_seg" id="566" />
-          <Map s="..|..|..|Fluid recirculation flow rate (incl. mucosa)" id="567" />
-          <Map s="J_iso_intestine" id="568" />
-          <Map s="..|..|..|Blood flow rate" id="569" />
-          <Map s="Q" id="570" />
-          <Map s="..|Fraction of regional blood flow rate" id="571" />
-          <Map s="regionalFractQ" id="572" />
-          <Map s="..|..|..|Mucosa blood flow fraction" id="573" />
-          <Map s="fractQ" id="574" />
-          <Map s="S1|Neighborhoods|Duodenum_int_Duodenum_cell|C1|Partition coefficient (interstitial/water)" id="575" />
-          <Map s="S1|Neighborhoods|Duodenum_int_Duodenum_cell|C1|Partition coefficient (intracellular/water)" id="576" />
-          <Map s="..|..|..|..|Lumen|UpperJejunum|Volume (gut wall)" id="577" />
-          <Map s="S1|Neighborhoods|UpperJejunum_pls_UpperJejunum_int|Surface area (plasma/interstitial)" id="578" />
-          <Map s="S1|Neighborhoods|UpperJejunum_int_UpperJejunum_cell|C1|Partition coefficient (interstitial/water)" id="579" />
-          <Map s="S1|Neighborhoods|UpperJejunum_int_UpperJejunum_cell|C1|Partition coefficient (intracellular/water)" id="580" />
-          <Map s="..|..|..|..|Lumen|LowerJejunum|Volume (gut wall)" id="581" />
-          <Map s="S1|Neighborhoods|LowerJejunum_pls_LowerJejunum_int|Surface area (plasma/interstitial)" id="582" />
-          <Map s="S1|Neighborhoods|LowerJejunum_int_LowerJejunum_cell|C1|Partition coefficient (interstitial/water)" id="583" />
-          <Map s="S1|Neighborhoods|LowerJejunum_int_LowerJejunum_cell|C1|Partition coefficient (intracellular/water)" id="584" />
-          <Map s="..|..|..|..|Lumen|UpperIleum|Volume (gut wall)" id="585" />
-          <Map s="S1|Neighborhoods|UpperIleum_pls_UpperIleum_int|Surface area (plasma/interstitial)" id="586" />
-          <Map s="S1|Neighborhoods|UpperIleum_int_UpperIleum_cell|C1|Partition coefficient (interstitial/water)" id="587" />
-          <Map s="S1|Neighborhoods|UpperIleum_int_UpperIleum_cell|C1|Partition coefficient (intracellular/water)" id="588" />
-          <Map s="..|..|..|..|Lumen|LowerIleum|Volume (gut wall)" id="589" />
-          <Map s="S1|Neighborhoods|LowerIleum_pls_LowerIleum_int|Surface area (plasma/interstitial)" id="590" />
-          <Map s="S1|Neighborhoods|LowerIleum_int_LowerIleum_cell|C1|Partition coefficient (interstitial/water)" id="591" />
-          <Map s="S1|Neighborhoods|LowerIleum_int_LowerIleum_cell|C1|Partition coefficient (intracellular/water)" id="592" />
-          <Map s="S1|Organism|SmallIntestine|Interstitial|Volume" id="593" />
-          <Map s="V_int" id="594" />
-          <Map s="S1|Organism|SmallIntestine|Mucosa|Duodenum|Interstitial|Volume" id="595" />
-          <Map s="V_int_duo" id="596" />
-          <Map s="S1|Organism|SmallIntestine|Mucosa|LowerIleum|Interstitial|Volume" id="597" />
-          <Map s="V_int_lil" id="598" />
-          <Map s="S1|Organism|SmallIntestine|Mucosa|LowerJejunum|Interstitial|Volume" id="599" />
-          <Map s="V_int_lje" id="600" />
-          <Map s="S1|Organism|SmallIntestine|Mucosa|UpperIleum|Interstitial|Volume" id="601" />
-          <Map s="V_int_uil" id="602" />
-          <Map s="S1|Organism|SmallIntestine|Mucosa|UpperJejunum|Interstitial|Volume" id="603" />
-          <Map s="V_int_uje" id="604" />
-          <Map s="S1|Organism|SmallIntestine|Intracellular|Volume" id="605" />
-          <Map s="V_cell" id="606" />
-          <Map s="S1|Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|Volume" id="607" />
-          <Map s="V_cell_duo" id="608" />
-          <Map s="S1|Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|Volume" id="609" />
-          <Map s="V_cell_lil" id="610" />
-          <Map s="S1|Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|Volume" id="611" />
-          <Map s="V_cell_lje" id="612" />
-          <Map s="S1|Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|Volume" id="613" />
-          <Map s="V_cell_uil" id="614" />
-          <Map s="S1|Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|Volume" id="615" />
-          <Map s="V_cell_uje" id="616" />
-          <Map s="S1|Organism|SmallIntestine|Intracellular|C1" id="617" />
-          <Map s="M_cell" id="618" />
-          <Map s="S1|Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|C1" id="619" />
-          <Map s="M_cell_duo" id="620" />
-          <Map s="S1|Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|C1" id="621" />
-          <Map s="M_cell_lil" id="622" />
-          <Map s="S1|Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|C1" id="623" />
-          <Map s="M_cell_lje" id="624" />
-          <Map s="S1|Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|C1" id="625" />
-          <Map s="M_cell_uil" id="626" />
-          <Map s="S1|Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|C1" id="627" />
-          <Map s="M_cell_uje" id="628" />
-          <Map s="S1|Organism|SmallIntestine|Interstitial|C1" id="629" />
-          <Map s="M_int" id="630" />
-          <Map s="S1|Organism|SmallIntestine|Mucosa|Duodenum|Interstitial|C1" id="631" />
-          <Map s="M_int_duo" id="632" />
-          <Map s="S1|Organism|SmallIntestine|Mucosa|LowerIleum|Interstitial|C1" id="633" />
-          <Map s="M_int_lil" id="634" />
-          <Map s="S1|Organism|SmallIntestine|Mucosa|LowerJejunum|Interstitial|C1" id="635" />
-          <Map s="M_int_lje" id="636" />
-          <Map s="S1|Organism|SmallIntestine|Mucosa|UpperIleum|Interstitial|C1" id="637" />
-          <Map s="M_int_uil" id="638" />
-          <Map s="S1|Organism|SmallIntestine|Mucosa|UpperJejunum|Interstitial|C1" id="639" />
-          <Map s="M_int_uje" id="640" />
-          <Map s="..|Mucosa|Caecum|Volume" id="641" />
-          <Map s="V_cae" id="642" />
-          <Map s="..|Mucosa|ColonAscendens|Volume" id="643" />
-          <Map s="V_ca" id="644" />
-          <Map s="..|Mucosa|ColonDescendens|Volume" id="645" />
-          <Map s="V_cd" id="646" />
-          <Map s="..|Mucosa|ColonSigmoid|Volume" id="647" />
-          <Map s="V_cs" id="648" />
-          <Map s="..|Mucosa|ColonTransversum|Volume" id="649" />
-          <Map s="V_ct" id="650" />
-          <Map s="..|Mucosa|Rectum|Volume" id="651" />
-          <Map s="V_rec" id="652" />
-          <Map s="..|Large intestinal transit time" id="653" />
-          <Map s="LITT" id="654" />
-          <Map s="..|Large intestinal transit time factor intercept" id="655" />
-          <Map s="..|Large intestinal transit time factor slope" id="656" />
-          <Map s="..|Mucosa|Caecum|Fluid recirculation flow rate" id="657" />
-          <Map s="J_iso_cae" id="658" />
-          <Map s="..|Mucosa|ColonAscendens|Fluid recirculation flow rate" id="659" />
-          <Map s="J_iso_colasc" id="660" />
-          <Map s="..|Mucosa|ColonDescendens|Fluid recirculation flow rate" id="661" />
-          <Map s="J_iso_coldesc" id="662" />
-          <Map s="..|Mucosa|ColonSigmoid|Fluid recirculation flow rate" id="663" />
-          <Map s="J_iso_colsigm" id="664" />
-          <Map s="..|Mucosa|ColonTransversum|Fluid recirculation flow rate" id="665" />
-          <Map s="J_iso_coltrans" id="666" />
-          <Map s="..|Mucosa|Rectum|Fluid recirculation flow rate" id="667" />
-          <Map s="J_iso_rect" id="668" />
-          <Map s="..|Mucosa|Caecum|Lymph flow rate" id="669" />
-          <Map s="Q_lymph_cae" id="670" />
-          <Map s="..|Mucosa|ColonAscendens|Lymph flow rate" id="671" />
-          <Map s="Q_lymph_colasc" id="672" />
-          <Map s="..|Mucosa|ColonDescendens|Lymph flow rate" id="673" />
-          <Map s="Q_lymph_coldesc" id="674" />
-          <Map s="..|Mucosa|ColonSigmoid|Lymph flow rate" id="675" />
-          <Map s="Q_lymph_colsigm" id="676" />
-          <Map s="..|Mucosa|ColonTransversum|Lymph flow rate" id="677" />
-          <Map s="Q_lymph_coltrans" id="678" />
-          <Map s="..|Mucosa|Rectum|Lymph flow rate" id="679" />
-          <Map s="Q_lymph_rect" id="680" />
-          <Map s="S1|Neighborhoods|LargeIntestine_pls_LargeIntestine_int|Surface area (plasma/interstitial)" id="681" />
-          <Map s="S1|Neighborhoods|LargeIntestine_int_LargeIntestine_cell|C1|Partition coefficient (interstitial/water)" id="682" />
-          <Map s="S1|Neighborhoods|LargeIntestine_int_LargeIntestine_cell|C1|Partition coefficient (intracellular/water)" id="683" />
-          <Map s="..|..|..|..|Lumen|Caecum|Volume (gut wall)" id="684" />
-          <Map s="S1|Neighborhoods|Caecum_pls_Caecum_int|Surface area (plasma/interstitial)" id="685" />
-          <Map s="S1|Neighborhoods|Caecum_int_Caecum_cell|C1|Partition coefficient (interstitial/water)" id="686" />
-          <Map s="S1|Neighborhoods|Caecum_int_Caecum_cell|C1|Partition coefficient (intracellular/water)" id="687" />
-          <Map s="..|..|..|..|Lumen|ColonAscendens|Volume (gut wall)" id="688" />
-          <Map s="S1|Neighborhoods|ColonAscendens_pls_ColonAscendens_int|Surface area (plasma/interstitial)" id="689" />
-          <Map s="S1|Neighborhoods|ColonAscendens_int_ColonAscendens_cell|C1|Partition coefficient (interstitial/water)" id="690" />
-          <Map s="S1|Neighborhoods|ColonAscendens_int_ColonAscendens_cell|C1|Partition coefficient (intracellular/water)" id="691" />
-          <Map s="..|..|..|..|Lumen|ColonTransversum|Volume (gut wall)" id="692" />
-          <Map s="S1|Neighborhoods|ColonTransversum_pls_ColonTransversum_int|Surface area (plasma/interstitial)" id="693" />
-          <Map s="S1|Neighborhoods|ColonTransversum_int_ColonTransversum_cell|C1|Partition coefficient (interstitial/water)" id="694" />
-          <Map s="S1|Neighborhoods|ColonTransversum_int_ColonTransversum_cell|C1|Partition coefficient (intracellular/water)" id="695" />
-          <Map s="..|..|..|..|Lumen|ColonDescendens|Volume (gut wall)" id="696" />
-          <Map s="S1|Neighborhoods|ColonDescendens_pls_ColonDescendens_int|Surface area (plasma/interstitial)" id="697" />
-          <Map s="S1|Neighborhoods|ColonDescendens_int_ColonDescendens_cell|C1|Partition coefficient (interstitial/water)" id="698" />
-          <Map s="S1|Neighborhoods|ColonDescendens_int_ColonDescendens_cell|C1|Partition coefficient (intracellular/water)" id="699" />
-          <Map s="..|..|..|..|Lumen|ColonSigmoid|Volume (gut wall)" id="700" />
-          <Map s="S1|Neighborhoods|ColonSigmoid_pls_ColonSigmoid_int|Surface area (plasma/interstitial)" id="701" />
-          <Map s="S1|Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|C1|Partition coefficient (interstitial/water)" id="702" />
-          <Map s="S1|Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|C1|Partition coefficient (intracellular/water)" id="703" />
-          <Map s="..|..|..|..|Lumen|Rectum|Volume (gut wall)" id="704" />
-          <Map s="S1|Neighborhoods|Rectum_pls_Rectum_int|Surface area (plasma/interstitial)" id="705" />
-          <Map s="S1|Neighborhoods|Rectum_int_Rectum_cell|C1|Partition coefficient (interstitial/water)" id="706" />
-          <Map s="S1|Neighborhoods|Rectum_int_Rectum_cell|C1|Partition coefficient (intracellular/water)" id="707" />
-          <Map s="S1|Organism|LargeIntestine|Interstitial|Volume" id="708" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|Caecum|Interstitial|Volume" id="709" />
-          <Map s="V_int_cae" id="710" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|ColonAscendens|Interstitial|Volume" id="711" />
-          <Map s="V_int_colasc" id="712" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|ColonDescendens|Interstitial|Volume" id="713" />
-          <Map s="V_int_coldesc" id="714" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|ColonSigmoid|Interstitial|Volume" id="715" />
-          <Map s="V_int_colsigm" id="716" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|ColonTransversum|Interstitial|Volume" id="717" />
-          <Map s="V_int_coltrans" id="718" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|Rectum|Interstitial|Volume" id="719" />
-          <Map s="V_int_rect" id="720" />
-          <Map s="S1|Organism|LargeIntestine|Intracellular|Volume" id="721" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|Caecum|Intracellular|Volume" id="722" />
-          <Map s="V_cell_cae" id="723" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|Volume" id="724" />
-          <Map s="V_cell_colasc" id="725" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|Volume" id="726" />
-          <Map s="V_cell_coldesc" id="727" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|Volume" id="728" />
-          <Map s="V_cell_colsigm" id="729" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|Volume" id="730" />
-          <Map s="V_cell_coltrans" id="731" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|Rectum|Intracellular|Volume" id="732" />
-          <Map s="V_cell_rect" id="733" />
-          <Map s="S1|Organism|LargeIntestine|Intracellular|C1" id="734" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|Caecum|Intracellular|C1" id="735" />
-          <Map s="M_cell_cae" id="736" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|C1" id="737" />
-          <Map s="M_cell_colasc" id="738" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|C1" id="739" />
-          <Map s="M_cell_coldesc" id="740" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|C1" id="741" />
-          <Map s="M_cell_colsigm" id="742" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|C1" id="743" />
-          <Map s="M_cell_coltrans" id="744" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|Rectum|Intracellular|C1" id="745" />
-          <Map s="M_cell_rect" id="746" />
-          <Map s="S1|Organism|LargeIntestine|Interstitial|C1" id="747" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|Caecum|Interstitial|C1" id="748" />
-          <Map s="M_int_cae" id="749" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|ColonAscendens|Interstitial|C1" id="750" />
-          <Map s="M_int_colasc" id="751" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|ColonDescendens|Interstitial|C1" id="752" />
-          <Map s="M_int_coldesc" id="753" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|ColonSigmoid|Interstitial|C1" id="754" />
-          <Map s="M_int_colsigm" id="755" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|ColonTransversum|Interstitial|C1" id="756" />
-          <Map s="M_int_coltrans" id="757" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|Rectum|Interstitial|C1" id="758" />
-          <Map s="M_int_rect" id="759" />
-          <Map s="S1|Neighborhoods|Liver_pls_Liver_int|Surface area (plasma/interstitial)" id="760" />
-          <Map s="S1|Neighborhoods|Liver_int_Liver_cell|C1|Partition coefficient (interstitial/water)" id="761" />
-          <Map s="S1|Neighborhoods|Liver_int_Liver_cell|C1|Partition coefficient (intracellular/water)" id="762" />
-          <Map s="S1|Neighborhoods|Lung_pls_Lung_int|Surface area (plasma/interstitial)" id="763" />
-          <Map s="S1|Organism|Bone|Blood flow rate" id="764" />
-          <Map s="Q_bon" id="765" />
-          <Map s="S1|Organism|Brain|Blood flow rate" id="766" />
-          <Map s="Q_brn" id="767" />
-          <Map s="S1|Organism|Fat|Blood flow rate" id="768" />
-          <Map s="Q_fat" id="769" />
-          <Map s="S1|Organism|Gonads|Blood flow rate" id="770" />
-          <Map s="Q_tes" id="771" />
-          <Map s="S1|Organism|Heart|Blood flow rate" id="772" />
-          <Map s="Q_hrt" id="773" />
-          <Map s="S1|Organism|Kidney|Blood flow rate" id="774" />
-          <Map s="Q_kid" id="775" />
-          <Map s="S1|Organism|LargeIntestine|Blood flow rate" id="776" />
-          <Map s="Q_lin" id="777" />
-          <Map s="S1|Organism|Liver|Blood flow rate" id="778" />
-          <Map s="Q_liv" id="779" />
-          <Map s="S1|Organism|Muscle|Blood flow rate" id="780" />
-          <Map s="Q_mus" id="781" />
-          <Map s="S1|Organism|Pancreas|Blood flow rate" id="782" />
-          <Map s="Q_pan" id="783" />
-          <Map s="S1|Organism|Skin|Blood flow rate" id="784" />
-          <Map s="Q_skn" id="785" />
-          <Map s="S1|Organism|SmallIntestine|Blood flow rate" id="786" />
-          <Map s="Q_sin" id="787" />
-          <Map s="S1|Organism|Spleen|Blood flow rate" id="788" />
-          <Map s="Q_spl" id="789" />
-          <Map s="S1|Organism|Stomach|Blood flow rate" id="790" />
-          <Map s="Q_sto" id="791" />
-          <Map s="S1|Neighborhoods|Lung_int_Lung_cell|C1|Partition coefficient (interstitial/water)" id="792" />
-          <Map s="S1|Neighborhoods|Lung_int_Lung_cell|C1|Partition coefficient (intracellular/water)" id="793" />
-          <Map s="S1|Neighborhoods|Muscle_pls_Muscle_int|Surface area (plasma/interstitial)" id="794" />
-          <Map s="S1|Neighborhoods|Muscle_int_Muscle_cell|C1|Partition coefficient (interstitial/water)" id="795" />
-          <Map s="S1|Neighborhoods|Muscle_int_Muscle_cell|C1|Partition coefficient (intracellular/water)" id="796" />
-          <Map s="S1|Neighborhoods|Pancreas_pls_Pancreas_int|Surface area (plasma/interstitial)" id="797" />
-          <Map s="S1|Neighborhoods|Pancreas_int_Pancreas_cell|C1|Partition coefficient (interstitial/water)" id="798" />
-          <Map s="S1|Neighborhoods|Pancreas_int_Pancreas_cell|C1|Partition coefficient (intracellular/water)" id="799" />
-          <Map s="S1|Organism|LargeIntestine|Lymph flow rate (incl. mucosa)" id="800" />
-          <Map s="Q_Lymph_lin_incl_Mucosa" id="801" />
-          <Map s="S1|Organism|Pancreas|Lymph flow rate" id="802" />
-          <Map s="Q_Lymph_pan" id="803" />
-          <Map s="S1|Organism|SmallIntestine|Lymph flow rate (incl. mucosa)" id="804" />
-          <Map s="Q_Lymph_sin_incl_Mucosa" id="805" />
-          <Map s="S1|Organism|Spleen|Lymph flow rate" id="806" />
-          <Map s="Q_Lymph_spl" id="807" />
-          <Map s="S1|Organism|Stomach|Lymph flow rate" id="808" />
-          <Map s="Q_Lymph_sto" id="809" />
-          <Map s="S1|Neighborhoods|Skin_pls_Skin_int|Surface area (plasma/interstitial)" id="810" />
-          <Map s="S1|Neighborhoods|Skin_int_Skin_cell|C1|Partition coefficient (interstitial/water)" id="811" />
-          <Map s="S1|Neighborhoods|Skin_int_Skin_cell|C1|Partition coefficient (intracellular/water)" id="812" />
-          <Map s="S1|Neighborhoods|Spleen_pls_Spleen_int|Surface area (plasma/interstitial)" id="813" />
-          <Map s="S1|Neighborhoods|Spleen_int_Spleen_cell|C1|Partition coefficient (interstitial/water)" id="814" />
-          <Map s="S1|Neighborhoods|Spleen_int_Spleen_cell|C1|Partition coefficient (intracellular/water)" id="815" />
-          <Map s="S1|Organism|Saliva|Volume" id="816" />
-          <Map s="V_slv" id="817" />
-          <Map s="..|GET_beta (Weibull function)" id="818" />
-          <Map s="Meal_beta" id="819" />
-          <Map s="..|Meal energy content" id="820" />
-          <Map s="Energy" id="821" />
-          <Map s="S1|Organism|Lumen|Stomach|GET_alpha (Weibull function) variability factor" id="822" />
-          <Map s="Variability_Factor" id="823" />
-          <Map s="..|Meal fraction solid" id="824" />
-          <Map s="fraction_solid" id="825" />
-          <Map s="S1|Organism|Lumen|Stomach|GET_beta (Weibull function) variability factor" id="826" />
-          <Map s="..|..|..|Meal volume" id="827" />
-          <Map s="MealVolume" id="828" />
-          <Map s="..|..|..|GET_alpha (Weibull function)" id="829" />
-          <Map s="Meal_alpha" id="830" />
-          <Map s="..|..|..|GET_beta (Weibull function)" id="831" />
-          <Map s="..|..|Start time" id="832" />
-          <Map s="StartTime" id="833" />
-          <Map s="..|..|..|Meal_pH_exponent" id="834" />
-          <Map s="S1|Organism|Lumen|Stomach|pH in fasted state" id="835" />
-          <Map s="S1|Organism|Lumen|Stomach|pH in fed state" id="836" />
-          <Map s="pH_fed" id="837" />
-          <Map s="..|Start time" id="838" />
-          <Map s="S1|Organism|Lumen|Stomach|Gastric emptying time" id="839" />
-          <Map s="StomachIntestinalTransitRate" id="840" />
-          <Map s="S1|Organism|Gallbladder|C1" id="841" />
-          <Map s="S1|Organism|Gallbladder|Gallbladder ejection fraction" id="842" />
-          <Map s="EHC_EjectionFraction" id="843" />
-          <Map s="S1|Organism|Gallbladder|Gallbladder ejection half-time" id="844" />
-          <Map s="EHC_Halftime" id="845" />
-          <Map s="..|..|Gallbladder emptying enabled" id="846" />
-          <Map s="EHC_Enabled" id="847" />
-          <Map s="..|..|Gallbladder emptying lag time" id="848" />
-          <Map s="EHCLagTime" id="849" />
-          <Map s="S1|Organism|Gallbladder|Time to complete gallbladder refilling" id="850" />
-          <Map s="GallbladderRefillTime" id="851" />
-          <Map s="S1|Organism|VenousBlood|BloodCells|C1|Concentration" id="852" />
-          <Map s="S1|Organism|VenousBlood|Plasma|C1|Concentration" id="853" />
-          <Map s="S1|C1|P (blood cells-&gt;plasma)" id="854" />
-          <Map s="P_rbc_pls" id="855" />
-          <Map s="Velocity" id="856" />
-          <Map s="S1|C1|P (plasma-&gt;blood cells)" id="857" />
-          <Map s="P_pls_rbc" id="858" />
-          <Map s="S1|Neighborhoods|VenousBlood_pls_VenousBlood_bc|Surface area (blood cells/plasma)" id="859" />
-          <Map s="SA_bc" id="860" />
-          <Map s="S1|Organism|VenousBlood|Plasma|..|Volume" id="861" />
-          <Map s="S1|Organism|Surface/Volume ratio (blood cells)" id="862" />
-          <Map s="A_to_V_bc" id="863" />
-          <Map s="S1|Organism|Lung|Plasma|..|Blood flow rate" id="864" />
-          <Map s="S1|Organism|Lung|BloodCells|..|Blood flow rate" id="865" />
-          <Map s="S1|Neighborhoods|ArterialBlood_pls_ArterialBlood_bc|Surface area (blood cells/plasma)" id="866" />
-          <Map s="S1|Organism|ArterialBlood|Plasma|..|Volume" id="867" />
-          <Map s="S1|Organism|Bone|Plasma|..|Blood flow rate" id="868" />
-          <Map s="S1|Organism|Bone|BloodCells|..|Blood flow rate" id="869" />
-          <Map s="S1|Organism|Protein ratio (interstial/plasma)" id="870" />
-          <Map s="f_proteins_int_to_pls" id="871" />
-          <Map s="S1|Organism|Vf (water,interstitial)" id="872" />
-          <Map s="f_water_int" id="873" />
-          <Map s="S1|Organism|Vf (water,plasma)" id="874" />
-          <Map s="f_water_pls" id="875" />
-          <Map s="S1|Organism|Bone|Interstitial|C1|Concentration" id="876" />
-          <Map s="S1|Neighborhoods|Bone_pls_Bone_int|C1|P (plasma&lt;-&gt;interstitial)" id="877" />
-          <Map s="P_endothelial" id="878" />
-          <Map s="S1|Neighborhoods|Bone_pls_Bone_int|C1|Partition coefficient (interstitial/plasma)" id="879" />
-          <Map s="K_int_pls" id="880" />
-          <Map s="SA" id="881" />
-          <Map s="S1|Organism|Bone|Plasma|..|Fraction vascular" id="882" />
-          <Map s="f_vas_org" id="883" />
-          <Map s="S1|Organism|Bone|Plasma|..|Volume" id="884" />
-          <Map s="S1|Organism|SA proportionality factor" id="885" />
-          <Map s="S1|Neighborhoods|Bone_pls_Bone_bc|Surface area (blood cells/plasma)" id="886" />
-          <Map s="..|Partition coefficient (intracellular/plasma)" id="887" />
-          <Map s="K_cell_pls" id="888" />
-          <Map s="S1|C1|Lipophilicity" id="889" />
-          <Map s="LogMA" id="890" />
-          <Map s="Log Units" id="891" />
-          <Map s="S1|C1|Partition coefficient (water/protein)" id="892" />
-          <Map s="KProt" id="893" />
-          <Map s="S1|Organism|Bone|Interstitial|..|Vf (lipid)" id="894" />
-          <Map s="f_lipids" id="895" />
-          <Map s="S1|Organism|Bone|Interstitial|..|Vf (protein)" id="896" />
-          <Map s="f_proteins" id="897" />
-          <Map s="S1|Organism|Bone|Interstitial|..|Vf (water)" id="898" />
-          <Map s="f_water" id="899" />
-          <Map s="..|P_int_cell_factor" id="900" />
-          <Map s="P_int_cell_factor" id="901" />
-          <Map s="S1|C1|Permeability" id="902" />
-          <Map s="P" id="903" />
-          <Map s="..|P_cell_int_factor" id="904" />
-          <Map s="P_cell_int_factor" id="905" />
-          <Map s="..|P (interstitial-&gt;intracellular)" id="906" />
-          <Map s="P_int_cell" id="907" />
-          <Map s="..|..|Surface area (interstitial/intracellular)" id="908" />
-          <Map s="..|P (intracellular-&gt;interstitial)" id="909" />
-          <Map s="P_cell_int" id="910" />
-          <Map s="S1|Organism|Bone|Intracellular|C1|Concentration" id="911" />
-          <Map s="S1|Neighborhoods|Bone_int_Bone_cell|C1|P*SA interstitial -&gt; intracellular" id="912" />
-          <Map s="PA_int_cell" id="913" />
-          <Map s="S1|Neighborhoods|Bone_int_Bone_cell|C1|P*SA intracellular -&gt; interstitial" id="914" />
-          <Map s="PA_cell_int" id="915" />
-          <Map s="S1|Organism|Bone|Interstitial|..|Volume" id="916" />
-          <Map s="S1|Organism|Brain|BloodCells|C1|Concentration" id="917" />
-          <Map s="S1|Organism|Brain|Plasma|C1|Concentration" id="918" />
-          <Map s="S1|Neighborhoods|Brain_pls_Brain_bc|Surface area (blood cells/plasma)" id="919" />
-          <Map s="S1|Organism|Brain|Plasma|..|Fraction vascular" id="920" />
-          <Map s="S1|Organism|Brain|Plasma|..|Volume" id="921" />
-          <Map s="S1|Organism|Brain|Interstitial|..|Vf (lipid)" id="922" />
-          <Map s="S1|Organism|Brain|Interstitial|..|Vf (protein)" id="923" />
-          <Map s="S1|Organism|Brain|Interstitial|..|Vf (water)" id="924" />
-          <Map s="S1|Neighborhoods|Brain_pls_Brain_int|C1|Partition coefficient (interstitial/plasma)" id="925" />
-          <Map s="S1|Organism|Brain|Intracellular|C1|Concentration" id="926" />
-          <Map s="S1|Organism|Brain|Interstitial|C1|Concentration" id="927" />
-          <Map s="S1|Neighborhoods|Brain_int_Brain_cell|C1|P*SA interstitial -&gt; intracellular" id="928" />
-          <Map s="S1|Neighborhoods|Brain_int_Brain_cell|C1|P*SA intracellular -&gt; interstitial" id="929" />
-          <Map s="S1|Organism|Brain|Interstitial|..|Volume" id="930" />
-          <Map s="S1|Organism|Brain|Plasma|..|Blood flow rate" id="931" />
-          <Map s="S1|Neighborhoods|Brain_pls_Brain_int|C1|P (plasma&lt;-&gt;interstitial)" id="932" />
-          <Map s="S1|Organism|Brain|BloodCells|..|Blood flow rate" id="933" />
-          <Map s="S1|Organism|Fat|Plasma|..|Blood flow rate" id="934" />
-          <Map s="S1|Neighborhoods|Fat_pls_Fat_bc|Surface area (blood cells/plasma)" id="935" />
-          <Map s="S1|Organism|Fat|Plasma|..|Fraction vascular" id="936" />
-          <Map s="S1|Organism|Fat|Plasma|..|Volume" id="937" />
-          <Map s="S1|Organism|Fat|Interstitial|..|Vf (lipid)" id="938" />
-          <Map s="S1|Organism|Fat|Interstitial|..|Vf (protein)" id="939" />
-          <Map s="S1|Organism|Fat|Interstitial|..|Vf (water)" id="940" />
-          <Map s="S1|Neighborhoods|Fat_pls_Fat_int|C1|Partition coefficient (interstitial/plasma)" id="941" />
-          <Map s="S1|Organism|Fat|Intracellular|C1|Concentration" id="942" />
-          <Map s="S1|Organism|Fat|Interstitial|C1|Concentration" id="943" />
-          <Map s="S1|Neighborhoods|Fat_int_Fat_cell|C1|P*SA interstitial -&gt; intracellular" id="944" />
-          <Map s="S1|Neighborhoods|Fat_int_Fat_cell|C1|P*SA intracellular -&gt; interstitial" id="945" />
-          <Map s="S1|Organism|Fat|Interstitial|..|Volume" id="946" />
-          <Map s="S1|Organism|Fat|BloodCells|..|Blood flow rate" id="947" />
-          <Map s="S1|Neighborhoods|Fat_pls_Fat_int|C1|P (plasma&lt;-&gt;interstitial)" id="948" />
-          <Map s="S1|Organism|Gonads|BloodCells|..|Blood flow rate" id="949" />
-          <Map s="S1|Organism|Gonads|BloodCells|C1|Concentration" id="950" />
-          <Map s="S1|Organism|Gonads|Plasma|..|Blood flow rate" id="951" />
-          <Map s="S1|Organism|Gonads|Plasma|C1|Concentration" id="952" />
-          <Map s="S1|Organism|Gonads|Interstitial|C1|Concentration" id="953" />
-          <Map s="S1|Neighborhoods|Gonads_pls_Gonads_int|C1|P (plasma&lt;-&gt;interstitial)" id="954" />
-          <Map s="S1|Neighborhoods|Gonads_pls_Gonads_int|C1|Partition coefficient (interstitial/plasma)" id="955" />
-          <Map s="S1|Organism|Gonads|Plasma|..|Fraction vascular" id="956" />
-          <Map s="S1|Organism|Gonads|Plasma|..|Volume" id="957" />
-          <Map s="S1|Neighborhoods|Gonads_pls_Gonads_bc|Surface area (blood cells/plasma)" id="958" />
-          <Map s="S1|Organism|Gonads|Interstitial|..|Vf (lipid)" id="959" />
-          <Map s="S1|Organism|Gonads|Interstitial|..|Vf (protein)" id="960" />
-          <Map s="S1|Organism|Gonads|Interstitial|..|Vf (water)" id="961" />
-          <Map s="S1|Organism|Gonads|Intracellular|C1|Concentration" id="962" />
-          <Map s="S1|Neighborhoods|Gonads_int_Gonads_cell|C1|P*SA interstitial -&gt; intracellular" id="963" />
-          <Map s="S1|Neighborhoods|Gonads_int_Gonads_cell|C1|P*SA intracellular -&gt; interstitial" id="964" />
-          <Map s="S1|Organism|Gonads|Interstitial|..|Volume" id="965" />
-          <Map s="S1|Organism|Heart|BloodCells|..|Blood flow rate" id="966" />
-          <Map s="S1|Organism|Heart|BloodCells|C1|Concentration" id="967" />
-          <Map s="S1|Organism|Heart|Interstitial|..|Vf (lipid)" id="968" />
-          <Map s="S1|Organism|Heart|Interstitial|..|Vf (protein)" id="969" />
-          <Map s="S1|Organism|Heart|Interstitial|..|Vf (water)" id="970" />
-          <Map s="S1|Neighborhoods|Heart_pls_Heart_int|C1|Partition coefficient (interstitial/plasma)" id="971" />
-          <Map s="S1|Organism|Heart|Intracellular|C1|Concentration" id="972" />
-          <Map s="S1|Organism|Heart|Interstitial|C1|Concentration" id="973" />
-          <Map s="S1|Neighborhoods|Heart_int_Heart_cell|C1|P*SA interstitial -&gt; intracellular" id="974" />
-          <Map s="S1|Neighborhoods|Heart_int_Heart_cell|C1|P*SA intracellular -&gt; interstitial" id="975" />
-          <Map s="S1|Organism|Heart|Interstitial|..|Volume" id="976" />
-          <Map s="S1|Organism|Heart|Plasma|C1|Concentration" id="977" />
-          <Map s="S1|Neighborhoods|Heart_pls_Heart_bc|Surface area (blood cells/plasma)" id="978" />
-          <Map s="S1|Organism|Heart|Plasma|..|Fraction vascular" id="979" />
-          <Map s="S1|Organism|Heart|Plasma|..|Volume" id="980" />
-          <Map s="S1|Neighborhoods|Heart_pls_Heart_int|C1|P (plasma&lt;-&gt;interstitial)" id="981" />
-          <Map s="S1|Organism|Heart|Plasma|..|Blood flow rate" id="982" />
-          <Map s="S1|Organism|Kidney|BloodCells|..|Blood flow rate" id="983" />
-          <Map s="S1|Organism|Kidney|BloodCells|C1|Concentration" id="984" />
-          <Map s="S1|Organism|Kidney|Interstitial|..|Vf (lipid)" id="985" />
-          <Map s="S1|Organism|Kidney|Interstitial|..|Vf (protein)" id="986" />
-          <Map s="S1|Organism|Kidney|Interstitial|..|Vf (water)" id="987" />
-          <Map s="S1|Neighborhoods|Kidney_pls_Kidney_int|C1|Partition coefficient (interstitial/plasma)" id="988" />
-          <Map s="S1|Organism|Kidney|Intracellular|C1|Concentration" id="989" />
-          <Map s="S1|Organism|Kidney|Interstitial|C1|Concentration" id="990" />
-          <Map s="S1|Neighborhoods|Kidney_int_Kidney_cell|C1|P*SA interstitial -&gt; intracellular" id="991" />
-          <Map s="S1|Neighborhoods|Kidney_int_Kidney_cell|C1|P*SA intracellular -&gt; interstitial" id="992" />
-          <Map s="S1|Organism|Kidney|Interstitial|..|Volume" id="993" />
-          <Map s="S1|Organism|Kidney|Plasma|C1|Concentration" id="994" />
-          <Map s="S1|Neighborhoods|Kidney_pls_Kidney_bc|Surface area (blood cells/plasma)" id="995" />
-          <Map s="S1|Organism|Kidney|Plasma|..|Fraction vascular" id="996" />
-          <Map s="S1|Organism|Kidney|Plasma|..|Volume" id="997" />
-          <Map s="S1|Neighborhoods|Kidney_pls_Kidney_int|C1|P (plasma&lt;-&gt;interstitial)" id="998" />
-          <Map s="S1|Organism|SmallIntestine|Mucosa|UpperJejunum|Plasma|C1|Concentration" id="999" />
-          <Map s="S1|Organism|SmallIntestine|Mucosa|UpperJejunum|Plasma|..|Blood flow rate" id="1000" />
-          <Map s="S1|Neighborhoods|UpperJejunum_pls_PortalVein_pls|C1|Mass transfer rate (mucosa to portal vein plasma)" id="1001" />
-          <Map s="MassTransferMucosaToPvePlasmaRate" id="1002" />
-          <Map s="S1|Neighborhoods|Lumen_uje_UpperJejunum_cell|C1|DrugAbsorption_trans|ProcessRate" id="1003" />
-          <Map s="P_1" id="1004" />
-          <Map s="..|pKa_pH_WS_cell_F1" id="1005" />
-          <Map s="..|pKa_pH_WS_cell_F2" id="1006" />
-          <Map s="..|pKa_pH_WS_cell_F3" id="1007" />
-          <Map s="S1|Organism|Lumen|UpperJejunum|Effective surface area enhancement factor" id="1008" />
-          <Map s="AeffFactor" id="1009" />
-          <Map s="S1|Organism|Lumen|UpperJejunum|Geometric surface area" id="1010" />
-          <Map s="Ageom" id="1011" />
-          <Map s="S1|Organism|Lumen|UpperJejunum|Liquid" id="1012" />
-          <Map s="DrugLiquid" id="1013" />
-          <Map s="S1|Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|C1|Concentration" id="1014" />
-          <Map s="DrugMucosa" id="1015" />
-          <Map s="S1|C1|Intestinal permeability (transcellular)" id="1016" />
-          <Map s="P_int_trans" id="1017" />
-          <Map s="S1|C1|Molecular weight" id="1018" />
-          <Map s="MW" id="1019" />
-          <Map s="Molecular weight" id="1020" />
-          <Map s="S1|Neighborhoods|Lumen_uje_UpperJejunum_cell|C1|P_int_trans_cell_lum_factor" id="1021" />
-          <Map s="P_int_trans_cell_lum_factor" id="1022" />
-          <Map s="S1|Neighborhoods|Lumen_uje_UpperJejunum_cell|C1|P_int_trans_lum_cell_factor" id="1023" />
-          <Map s="P_int_trans_lum_cell_factor" id="1024" />
-          <Map s="S1|Organism|Lumen|UpperJejunum|C1|Solubility" id="1025" />
-          <Map s="S1|Organism|Lumen|UpperJejunum|..|OralApplicationsEnabled" id="1026" />
-          <Map s="S1|Organism|Lumen|UpperJejunum|..|Transcellular absorption sink condition" id="1027" />
-          <Map s="SinkCondition_trans" id="1028" />
-          <Map s="..|pKa_pH_WS_cell_K1" id="1029" />
-          <Map s="..|pKa_pH_WS_cell_K2" id="1030" />
-          <Map s="..|pKa_pH_WS_cell_K3" id="1031" />
-          <Map s="..|pKa_pH_WS_cell_K4" id="1032" />
-          <Map s="..|pKa_pH_WS_cell_K5" id="1033" />
-          <Map s="..|pKa_pH_WS_cell_K6" id="1034" />
-          <Map s="..|pKa_pH_WS_cell_K7" id="1035" />
-          <Map s="..|pKa_pH_WS_cell_K8" id="1036" />
-          <Map s="S1|C1|base_For_Pint_Factor" id="1037" />
-          <Map s="S1|C1|Use pH- and pKa-dependent penalty factor for charged molecule fraction" id="1038" />
-          <Map s="UsePenaltyFactor" id="1039" />
-          <Map s="S1|Neighborhoods|UpperJejunum_int_UpperJejunum_cell|C1|Partition coefficient (intracellular/plasma)" id="1040" />
-          <Map s="S1|Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|pH" id="1041" />
-          <Map s="S1|Organism|Lumen|UpperJejunum|pH" id="1042" />
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-          <Map s="S1|Organism|LargeIntestine|Mucosa|ColonTransversum|Plasma|..|Blood flow rate" id="1253" />
-          <Map s="S1|Neighborhoods|LargeIntestine_pls_ColonTransversum_pls|C1|Mass transfer rate (intestine to mucosa plasma)" id="1254" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|ColonAscendens|BloodCells|..|Blood flow rate" id="1255" />
-          <Map s="S1|Neighborhoods|LargeIntestine_bc_ColonAscendens_bc|C1|Mass transfer rate (intestine to mucosa blood cells)" id="1256" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|ColonAscendens|Plasma|..|Blood flow rate" id="1257" />
-          <Map s="S1|Neighborhoods|LargeIntestine_pls_ColonAscendens_pls|C1|Mass transfer rate (intestine to mucosa plasma)" id="1258" />
-          <Map s="S1|Neighborhoods|LargeIntestine_pls_LargeIntestine_bc|Surface area (blood cells/plasma)" id="1259" />
-          <Map s="S1|Organism|LargeIntestine|Plasma|..|Fraction vascular" id="1260" />
-          <Map s="S1|Organism|LargeIntestine|Plasma|..|Volume" id="1261" />
-          <Map s="S1|Organism|LargeIntestine|Plasma|..|Volume (mucosa)" id="1262" />
-          <Map s="S1|Organism|LargeIntestine|Interstitial|..|Vf (lipid)" id="1263" />
-          <Map s="S1|Organism|LargeIntestine|Interstitial|..|Vf (protein)" id="1264" />
-          <Map s="S1|Organism|LargeIntestine|Interstitial|..|Vf (water)" id="1265" />
-          <Map s="S1|Neighborhoods|LargeIntestine_pls_LargeIntestine_int|C1|Partition coefficient (interstitial/plasma)" id="1266" />
-          <Map s="S1|Organism|LargeIntestine|Intracellular|C1|Concentration" id="1267" />
-          <Map s="S1|Organism|LargeIntestine|Interstitial|C1|Concentration" id="1268" />
-          <Map s="S1|Neighborhoods|LargeIntestine_int_LargeIntestine_cell|C1|P*SA interstitial -&gt; intracellular" id="1269" />
-          <Map s="S1|Neighborhoods|LargeIntestine_int_LargeIntestine_cell|C1|P*SA intracellular -&gt; interstitial" id="1270" />
-          <Map s="S1|Organism|LargeIntestine|Interstitial|..|Volume" id="1271" />
-          <Map s="S1|Organism|LargeIntestine|Volume (mucosa)" id="1272" />
-          <Map s="S1|Neighborhoods|LargeIntestine_pls_LargeIntestine_int|C1|P (plasma&lt;-&gt;interstitial)" id="1273" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|Caecum|Plasma|..|Blood flow rate" id="1274" />
-          <Map s="S1|Neighborhoods|LargeIntestine_pls_Caecum_pls|C1|Mass transfer rate (intestine to mucosa plasma)" id="1275" />
-          <Map s="S1|Organism|LargeIntestine|Plasma|..|Blood flow rate" id="1276" />
-          <Map s="S1|Organism|LargeIntestine|Plasma|..|Mucosa blood flow fraction" id="1277" />
-          <Map s="S1|Organism|Liver|BloodCells|C1|Concentration" id="1278" />
-          <Map s="S1|Organism|Liver|Plasma|C1|Concentration" id="1279" />
-          <Map s="S1|Neighborhoods|Liver_pls_Liver_bc|Surface area (blood cells/plasma)" id="1280" />
-          <Map s="S1|Organism|Liver|Plasma|..|Fraction vascular" id="1281" />
-          <Map s="S1|Organism|Liver|Plasma|..|Volume" id="1282" />
-          <Map s="S1|Organism|Liver|Plasma|..|Blood flow rate" id="1283" />
-          <Map s="S1|Organism|Liver|Plasma|..|..|PortalVein|Blood flow rate" id="1284" />
-          <Map s="Q_pve" id="1285" />
-          <Map s="S1|Organism|Liver|Interstitial|..|Vf (lipid)" id="1286" />
-          <Map s="S1|Organism|Liver|Interstitial|..|Vf (protein)" id="1287" />
-          <Map s="S1|Organism|Liver|Interstitial|..|Vf (water)" id="1288" />
-          <Map s="..|P*SA interstitial -&gt; intracellular" id="1289" />
-          <Map s="PA_liv" id="1290" />
-          <Map s="S1|Organism|Liver|Interstitial|..|Blood flow rate" id="1291" />
-          <Map s="S1|Organism|Liver|Interstitial|..|..|PortalVein|Blood flow rate" id="1292" />
-          <Map s="S1|Neighborhoods|Liver_pls_Liver_int|C1|Partition coefficient (interstitial/plasma)" id="1293" />
-          <Map s="S1|Organism|Liver|Intracellular|C1|Concentration" id="1294" />
-          <Map s="S1|Organism|Liver|Interstitial|C1|Concentration" id="1295" />
-          <Map s="S1|Neighborhoods|Liver_int_Liver_cell|C1|P*SA interstitial -&gt; intracellular" id="1296" />
-          <Map s="S1|Neighborhoods|Liver_int_Liver_cell|C1|P*SA intracellular -&gt; interstitial" id="1297" />
-          <Map s="S1|Organism|Liver|Interstitial|..|Volume" id="1298" />
-          <Map s="S1|Neighborhoods|Liver_pls_Liver_int|C1|P (plasma&lt;-&gt;interstitial)" id="1299" />
-          <Map s="GallbladderEmptyingRate" id="1300" />
-          <Map s="S1|Organism|Liver|BloodCells|..|Blood flow rate" id="1301" />
-          <Map s="S1|Organism|Liver|BloodCells|..|..|PortalVein|Blood flow rate" id="1302" />
-          <Map s="S1|Organism|Lung|BloodCells|C1|Concentration" id="1303" />
-          <Map s="S1|Organism|Lung|Plasma|C1|Concentration" id="1304" />
-          <Map s="S1|Neighborhoods|Lung_pls_Lung_bc|Surface area (blood cells/plasma)" id="1305" />
-          <Map s="S1|Organism|Lung|Plasma|..|Fraction vascular" id="1306" />
-          <Map s="S1|Organism|Lung|Plasma|..|Volume" id="1307" />
-          <Map s="S1|Organism|Lung|Interstitial|C1|Concentration" id="1308" />
-          <Map s="S1|Neighborhoods|Lung_pls_Lung_int|C1|P (plasma&lt;-&gt;interstitial)" id="1309" />
-          <Map s="S1|Neighborhoods|Lung_pls_Lung_int|C1|Partition coefficient (interstitial/plasma)" id="1310" />
-          <Map s="S1|Organism|Lung|Interstitial|..|Vf (lipid)" id="1311" />
-          <Map s="S1|Organism|Lung|Interstitial|..|Vf (protein)" id="1312" />
-          <Map s="S1|Organism|Lung|Interstitial|..|Vf (water)" id="1313" />
-          <Map s="S1|Organism|Lung|Intracellular|C1|Concentration" id="1314" />
-          <Map s="S1|Neighborhoods|Lung_int_Lung_cell|C1|P*SA interstitial -&gt; intracellular" id="1315" />
-          <Map s="S1|Neighborhoods|Lung_int_Lung_cell|C1|P*SA intracellular -&gt; interstitial" id="1316" />
-          <Map s="S1|Organism|Lung|Interstitial|..|Volume" id="1317" />
-          <Map s="S1|Organism|Muscle|Interstitial|..|Vf (lipid)" id="1318" />
-          <Map s="S1|Organism|Muscle|Interstitial|..|Vf (protein)" id="1319" />
-          <Map s="S1|Organism|Muscle|Interstitial|..|Vf (water)" id="1320" />
-          <Map s="S1|Neighborhoods|Muscle_pls_Muscle_int|C1|Partition coefficient (interstitial/plasma)" id="1321" />
-          <Map s="S1|Organism|Muscle|Intracellular|C1|Concentration" id="1322" />
-          <Map s="S1|Organism|Muscle|Interstitial|C1|Concentration" id="1323" />
-          <Map s="S1|Neighborhoods|Muscle_int_Muscle_cell|C1|P*SA interstitial -&gt; intracellular" id="1324" />
-          <Map s="S1|Neighborhoods|Muscle_int_Muscle_cell|C1|P*SA intracellular -&gt; interstitial" id="1325" />
-          <Map s="S1|Organism|Muscle|Interstitial|..|Volume" id="1326" />
-          <Map s="S1|Neighborhoods|Muscle_pls_Muscle_bc|Surface area (blood cells/plasma)" id="1327" />
-          <Map s="S1|Organism|Muscle|Plasma|..|Fraction vascular" id="1328" />
-          <Map s="S1|Organism|Muscle|Plasma|..|Volume" id="1329" />
-          <Map s="S1|Neighborhoods|Muscle_pls_Muscle_int|C1|P (plasma&lt;-&gt;interstitial)" id="1330" />
-          <Map s="S1|Organism|Muscle|Plasma|..|Blood flow rate" id="1331" />
-          <Map s="S1|Organism|Muscle|BloodCells|..|Blood flow rate" id="1332" />
-          <Map s="S1|Organism|Pancreas|BloodCells|C1|Concentration" id="1333" />
-          <Map s="S1|Organism|Pancreas|Plasma|C1|Concentration" id="1334" />
-          <Map s="S1|Neighborhoods|Pancreas_pls_Pancreas_bc|Surface area (blood cells/plasma)" id="1335" />
-          <Map s="S1|Organism|Pancreas|Plasma|..|Fraction vascular" id="1336" />
-          <Map s="S1|Organism|Pancreas|Plasma|..|Volume" id="1337" />
-          <Map s="S1|Organism|Pancreas|Interstitial|C1|Concentration" id="1338" />
-          <Map s="S1|Neighborhoods|Pancreas_pls_Pancreas_int|C1|P (plasma&lt;-&gt;interstitial)" id="1339" />
-          <Map s="S1|Neighborhoods|Pancreas_pls_Pancreas_int|C1|Partition coefficient (interstitial/plasma)" id="1340" />
-          <Map s="S1|Organism|Pancreas|Plasma|..|Blood flow rate" id="1341" />
-          <Map s="S1|Organism|Pancreas|Interstitial|..|Vf (lipid)" id="1342" />
-          <Map s="S1|Organism|Pancreas|Interstitial|..|Vf (protein)" id="1343" />
-          <Map s="S1|Organism|Pancreas|Interstitial|..|Vf (water)" id="1344" />
-          <Map s="S1|Organism|Pancreas|Intracellular|C1|Concentration" id="1345" />
-          <Map s="S1|Neighborhoods|Pancreas_int_Pancreas_cell|C1|P*SA interstitial -&gt; intracellular" id="1346" />
-          <Map s="S1|Neighborhoods|Pancreas_int_Pancreas_cell|C1|P*SA intracellular -&gt; interstitial" id="1347" />
-          <Map s="S1|Organism|Pancreas|Interstitial|..|Volume" id="1348" />
-          <Map s="S1|Organism|Pancreas|BloodCells|..|Blood flow rate" id="1349" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|Rectum|Intracellular|pH" id="1350" />
-          <Map s="S1|Organism|Lumen|Rectum|Effective surface area enhancement factor" id="1351" />
-          <Map s="S1|Organism|Lumen|Rectum|Geometric surface area" id="1352" />
-          <Map s="S1|Organism|Lumen|Rectum|Liquid" id="1353" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|Rectum|Intracellular|C1|Concentration" id="1354" />
-          <Map s="S1|Neighborhoods|Lumen_rect_Rectum_cell|C1|P_int_trans_cell_lum_factor" id="1355" />
-          <Map s="S1|Neighborhoods|Lumen_rect_Rectum_cell|C1|P_int_trans_lum_cell_factor" id="1356" />
-          <Map s="S1|Organism|Lumen|Rectum|C1|Solubility" id="1357" />
-          <Map s="S1|Organism|Lumen|Rectum|..|Transcellular absorption sink condition" id="1358" />
-          <Map s="S1|Neighborhoods|Rectum_int_Rectum_cell|C1|Partition coefficient (intracellular/plasma)" id="1359" />
-          <Map s="S1|Neighborhoods|Lumen_rect_Rectum_cell|C1|DrugAbsorption_trans|ProcessRate" id="1360" />
-          <Map s="S1|Organism|Lumen|Rectum|pH" id="1361" />
-          <Map s="S1|Neighborhoods|Lumen_rect_Rectum_cell|C1|Drug absorption rate (lumen to mucosa)" id="1362" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|Rectum|Plasma|C1|Concentration" id="1363" />
-          <Map s="S1|Neighborhoods|Rectum_pls_PortalVein_pls|C1|Mass transfer rate (mucosa to portal vein plasma)" id="1364" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|Rectum|BloodCells|C1|Concentration" id="1365" />
-          <Map s="S1|Neighborhoods|Rectum_bc_PortalVein_bc|C1|Mass transfer rate (mucosa to portal vein blood cells)" id="1366" />
-          <Map s="S1|Organism|Lumen|Rectum|..|Paracellular absorption sink condition" id="1367" />
-          <Map s="S1|Organism|PortalVein|Plasma|..|Blood flow rate" id="1368" />
-          <Map s="S1|Organism|PortalVein|Plasma|C1|Concentration" id="1369" />
-          <Map s="S1|Organism|PortalVein|BloodCells|C1|Concentration" id="1370" />
-          <Map s="S1|Neighborhoods|PortalVein_pls_PortalVein_bc|Surface area (blood cells/plasma)" id="1371" />
-          <Map s="S1|Organism|PortalVein|Plasma|..|Volume" id="1372" />
-          <Map s="S1|Organism|PortalVein|BloodCells|..|Blood flow rate" id="1373" />
-          <Map s="S1|Organism|Skin|Plasma|..|Blood flow rate" id="1374" />
-          <Map s="S1|Neighborhoods|Skin_pls_Skin_bc|Surface area (blood cells/plasma)" id="1375" />
-          <Map s="S1|Organism|Skin|Plasma|..|Fraction vascular" id="1376" />
-          <Map s="S1|Organism|Skin|Plasma|..|Volume" id="1377" />
-          <Map s="S1|Organism|Skin|Interstitial|..|Vf (lipid)" id="1378" />
-          <Map s="S1|Organism|Skin|Interstitial|..|Vf (protein)" id="1379" />
-          <Map s="S1|Organism|Skin|Interstitial|..|Vf (water)" id="1380" />
-          <Map s="S1|Neighborhoods|Skin_pls_Skin_int|C1|Partition coefficient (interstitial/plasma)" id="1381" />
-          <Map s="S1|Organism|Skin|Intracellular|C1|Concentration" id="1382" />
-          <Map s="S1|Organism|Skin|Interstitial|C1|Concentration" id="1383" />
-          <Map s="S1|Neighborhoods|Skin_int_Skin_cell|C1|P*SA interstitial -&gt; intracellular" id="1384" />
-          <Map s="S1|Neighborhoods|Skin_int_Skin_cell|C1|P*SA intracellular -&gt; interstitial" id="1385" />
-          <Map s="S1|Organism|Skin|Interstitial|..|Volume" id="1386" />
-          <Map s="S1|Neighborhoods|Skin_pls_Skin_int|C1|P (plasma&lt;-&gt;interstitial)" id="1387" />
-          <Map s="S1|Organism|Skin|BloodCells|..|Blood flow rate" id="1388" />
-          <Map s="S1|Organism|Spleen|Plasma|..|Blood flow rate" id="1389" />
-          <Map s="S1|Organism|Spleen|Plasma|C1|Concentration" id="1390" />
-          <Map s="S1|Organism|Spleen|Interstitial|..|Vf (lipid)" id="1391" />
-          <Map s="S1|Organism|Spleen|Interstitial|..|Vf (protein)" id="1392" />
-          <Map s="S1|Organism|Spleen|Interstitial|..|Vf (water)" id="1393" />
-          <Map s="S1|Neighborhoods|Spleen_pls_Spleen_int|C1|Partition coefficient (interstitial/plasma)" id="1394" />
-          <Map s="S1|Organism|Spleen|Intracellular|C1|Concentration" id="1395" />
-          <Map s="S1|Organism|Spleen|Interstitial|C1|Concentration" id="1396" />
-          <Map s="S1|Neighborhoods|Spleen_int_Spleen_cell|C1|P*SA interstitial -&gt; intracellular" id="1397" />
-          <Map s="S1|Neighborhoods|Spleen_int_Spleen_cell|C1|P*SA intracellular -&gt; interstitial" id="1398" />
-          <Map s="S1|Organism|Spleen|Interstitial|..|Volume" id="1399" />
-          <Map s="S1|Neighborhoods|Spleen_pls_Spleen_int|C1|P (plasma&lt;-&gt;interstitial)" id="1400" />
-          <Map s="S1|Organism|Spleen|Plasma|..|Fraction vascular" id="1401" />
-          <Map s="S1|Organism|Spleen|Plasma|..|Volume" id="1402" />
-          <Map s="S1|Organism|Spleen|BloodCells|C1|Concentration" id="1403" />
-          <Map s="S1|Neighborhoods|Spleen_pls_Spleen_bc|Surface area (blood cells/plasma)" id="1404" />
-          <Map s="S1|Organism|Spleen|BloodCells|..|Blood flow rate" id="1405" />
-          <Map s="..|SalivaPlasmaRatio" id="1406" />
-          <Map s="R" id="1407" />
-          <Map s="S1|Organism|Saliva|Saliva|pH (saliva)" id="1408" />
-          <Map s="pH_slv" id="1409" />
-          <Map s="S1|Organism|pH (plasma)" id="1410" />
-          <Map s="pH_PLS" id="1411" />
-          <Map s="S1|Organism|Saliva|SalivaGland|..|Saliva flow rate" id="1412" />
-          <Map s="Q_slv" id="1413" />
-          <Map s="S1|Organism|Saliva|SalivaGland|..|..|ArterialBlood|Plasma|C1|Concentration" id="1414" />
-          <Map s="S1|Organism|Saliva|Saliva|C1|Concentration" id="1415" />
-          <Map s="C_slv" id="1416" />
-          <Map s="S1|Neighborhoods|Saliva_slv_Saliva_slv|C1|Partition coefficient (intracellular/plasma)" id="1417" />
-          <Map s="K_slv_pls" id="1418" />
-          <Map s="S1|Organism|SmallIntestine|Mucosa|Duodenum|BloodCells|C1|Concentration" id="1419" />
-          <Map s="S1|Organism|SmallIntestine|Mucosa|Duodenum|Plasma|C1|Concentration" id="1420" />
-          <Map s="S1|Neighborhoods|Duodenum_pls_Duodenum_bc|Surface area (blood cells/plasma)" id="1421" />
-          <Map s="S1|Organism|SmallIntestine|Mucosa|Duodenum|Plasma|..|Fraction vascular" id="1422" />
-          <Map s="S1|Organism|SmallIntestine|Mucosa|Duodenum|Plasma|..|Volume" id="1423" />
-          <Map s="S1|Organism|SmallIntestine|Mucosa|Duodenum|Interstitial|C1|Concentration" id="1424" />
-          <Map s="S1|Neighborhoods|Duodenum_pls_Duodenum_int|C1|P (plasma&lt;-&gt;interstitial)" id="1425" />
-          <Map s="S1|Neighborhoods|Duodenum_pls_Duodenum_int|C1|Partition coefficient (interstitial/plasma)" id="1426" />
-          <Map s="S1|C1|Mucosa permeability scale factor (transcellular)" id="1427" />
-          <Map s="P_int_scalefactor" id="1428" />
-          <Map s="S1|Organism|SmallIntestine|Mucosa|Duodenum|Interstitial|..|Vf (lipid)" id="1429" />
-          <Map s="S1|Organism|SmallIntestine|Mucosa|Duodenum|Interstitial|..|Vf (protein)" id="1430" />
-          <Map s="S1|Organism|SmallIntestine|Mucosa|Duodenum|Interstitial|..|Vf (water)" id="1431" />
-          <Map s="S1|Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|C1|Concentration" id="1432" />
-          <Map s="S1|Neighborhoods|Duodenum_int_Duodenum_cell|C1|P*SA interstitial -&gt; intracellular" id="1433" />
-          <Map s="S1|Neighborhoods|Duodenum_int_Duodenum_cell|C1|P*SA intracellular -&gt; interstitial" id="1434" />
-          <Map s="S1|Organism|Lumen|Duodenum|Effective surface area enhancement factor" id="1435" />
-          <Map s="S1|Organism|Lumen|Duodenum|Geometric surface area" id="1436" />
-          <Map s="S1|Organism|Lumen|Duodenum|Microvilli factor" id="1437" />
-          <Map s="MicrovilliFactor" id="1438" />
-          <Map s="S1|Organism|SmallIntestine|Mucosa|UpperJejunum|Interstitial|..|Vf (lipid)" id="1439" />
-          <Map s="S1|Organism|SmallIntestine|Mucosa|UpperJejunum|Interstitial|..|Vf (protein)" id="1440" />
-          <Map s="S1|Organism|SmallIntestine|Mucosa|UpperJejunum|Interstitial|..|Vf (water)" id="1441" />
-          <Map s="S1|Organism|SmallIntestine|Mucosa|UpperJejunum|Interstitial|C1|Concentration" id="1442" />
-          <Map s="S1|Neighborhoods|UpperJejunum_int_UpperJejunum_cell|C1|P*SA interstitial -&gt; intracellular" id="1443" />
-          <Map s="S1|Neighborhoods|UpperJejunum_int_UpperJejunum_cell|C1|P*SA intracellular -&gt; interstitial" id="1444" />
-          <Map s="S1|Organism|Lumen|UpperJejunum|Microvilli factor" id="1445" />
-          <Map s="S1|Neighborhoods|UpperJejunum_pls_UpperJejunum_bc|Surface area (blood cells/plasma)" id="1446" />
-          <Map s="S1|Organism|SmallIntestine|Mucosa|UpperJejunum|Plasma|..|Fraction vascular" id="1447" />
-          <Map s="S1|Organism|SmallIntestine|Mucosa|UpperJejunum|Plasma|..|Volume" id="1448" />
-          <Map s="S1|Neighborhoods|UpperJejunum_pls_UpperJejunum_int|C1|P (plasma&lt;-&gt;interstitial)" id="1449" />
-          <Map s="S1|Neighborhoods|UpperJejunum_pls_UpperJejunum_int|C1|Partition coefficient (interstitial/plasma)" id="1450" />
-          <Map s="S1|Organism|SmallIntestine|Mucosa|LowerJejunum|Interstitial|C1|Concentration" id="1451" />
-          <Map s="S1|Neighborhoods|LowerJejunum_pls_LowerJejunum_int|C1|P (plasma&lt;-&gt;interstitial)" id="1452" />
-          <Map s="S1|Neighborhoods|LowerJejunum_pls_LowerJejunum_int|C1|Partition coefficient (interstitial/plasma)" id="1453" />
-          <Map s="S1|Organism|SmallIntestine|Mucosa|LowerJejunum|Plasma|..|Fraction vascular" id="1454" />
-          <Map s="S1|Organism|SmallIntestine|Mucosa|LowerJejunum|Plasma|..|Volume" id="1455" />
-          <Map s="S1|Neighborhoods|LowerJejunum_pls_LowerJejunum_bc|Surface area (blood cells/plasma)" id="1456" />
-          <Map s="S1|Organism|SmallIntestine|Mucosa|LowerJejunum|Interstitial|..|Vf (lipid)" id="1457" />
-          <Map s="S1|Organism|SmallIntestine|Mucosa|LowerJejunum|Interstitial|..|Vf (protein)" id="1458" />
-          <Map s="S1|Organism|SmallIntestine|Mucosa|LowerJejunum|Interstitial|..|Vf (water)" id="1459" />
-          <Map s="S1|Neighborhoods|LowerJejunum_int_LowerJejunum_cell|C1|P*SA interstitial -&gt; intracellular" id="1460" />
-          <Map s="S1|Neighborhoods|LowerJejunum_int_LowerJejunum_cell|C1|P*SA intracellular -&gt; interstitial" id="1461" />
-          <Map s="S1|Organism|Lumen|LowerJejunum|Microvilli factor" id="1462" />
-          <Map s="S1|Organism|SmallIntestine|Mucosa|UpperIleum|Interstitial|..|Vf (lipid)" id="1463" />
-          <Map s="S1|Organism|SmallIntestine|Mucosa|UpperIleum|Interstitial|..|Vf (protein)" id="1464" />
-          <Map s="S1|Organism|SmallIntestine|Mucosa|UpperIleum|Interstitial|..|Vf (water)" id="1465" />
-          <Map s="S1|Organism|SmallIntestine|Mucosa|UpperIleum|Interstitial|C1|Concentration" id="1466" />
-          <Map s="S1|Neighborhoods|UpperIleum_int_UpperIleum_cell|C1|P*SA interstitial -&gt; intracellular" id="1467" />
-          <Map s="S1|Neighborhoods|UpperIleum_int_UpperIleum_cell|C1|P*SA intracellular -&gt; interstitial" id="1468" />
-          <Map s="S1|Organism|Lumen|UpperIleum|Microvilli factor" id="1469" />
-          <Map s="S1|Neighborhoods|UpperIleum_pls_UpperIleum_bc|Surface area (blood cells/plasma)" id="1470" />
-          <Map s="S1|Organism|SmallIntestine|Mucosa|UpperIleum|Plasma|..|Fraction vascular" id="1471" />
-          <Map s="S1|Organism|SmallIntestine|Mucosa|UpperIleum|Plasma|..|Volume" id="1472" />
-          <Map s="S1|Neighborhoods|UpperIleum_pls_UpperIleum_int|C1|P (plasma&lt;-&gt;interstitial)" id="1473" />
-          <Map s="S1|Neighborhoods|UpperIleum_pls_UpperIleum_int|C1|Partition coefficient (interstitial/plasma)" id="1474" />
-          <Map s="S1|Neighborhoods|LowerIleum_pls_LowerIleum_bc|Surface area (blood cells/plasma)" id="1475" />
-          <Map s="S1|Organism|SmallIntestine|Mucosa|LowerIleum|Plasma|..|Fraction vascular" id="1476" />
-          <Map s="S1|Organism|SmallIntestine|Mucosa|LowerIleum|Plasma|..|Volume" id="1477" />
-          <Map s="S1|Organism|SmallIntestine|Mucosa|LowerIleum|Interstitial|..|Vf (lipid)" id="1478" />
-          <Map s="S1|Organism|SmallIntestine|Mucosa|LowerIleum|Interstitial|..|Vf (protein)" id="1479" />
-          <Map s="S1|Organism|SmallIntestine|Mucosa|LowerIleum|Interstitial|..|Vf (water)" id="1480" />
-          <Map s="S1|Organism|SmallIntestine|Mucosa|LowerIleum|Interstitial|C1|Concentration" id="1481" />
-          <Map s="S1|Neighborhoods|LowerIleum_int_LowerIleum_cell|C1|P*SA interstitial -&gt; intracellular" id="1482" />
-          <Map s="S1|Neighborhoods|LowerIleum_int_LowerIleum_cell|C1|P*SA intracellular -&gt; interstitial" id="1483" />
-          <Map s="S1|Organism|Lumen|LowerIleum|Microvilli factor" id="1484" />
-          <Map s="S1|Neighborhoods|LowerIleum_pls_LowerIleum_int|C1|P (plasma&lt;-&gt;interstitial)" id="1485" />
-          <Map s="S1|Neighborhoods|LowerIleum_pls_LowerIleum_int|C1|Partition coefficient (interstitial/plasma)" id="1486" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|Caecum|Interstitial|C1|Concentration" id="1487" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|Caecum|Plasma|C1|Concentration" id="1488" />
-          <Map s="S1|Neighborhoods|Caecum_pls_Caecum_int|C1|P (plasma&lt;-&gt;interstitial)" id="1489" />
-          <Map s="S1|Neighborhoods|Caecum_pls_Caecum_int|C1|Partition coefficient (interstitial/plasma)" id="1490" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|Caecum|Plasma|..|Fraction vascular" id="1491" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|Caecum|Plasma|..|Volume" id="1492" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|Caecum|BloodCells|C1|Concentration" id="1493" />
-          <Map s="S1|Neighborhoods|Caecum_pls_Caecum_bc|Surface area (blood cells/plasma)" id="1494" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|Caecum|Interstitial|..|Vf (lipid)" id="1495" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|Caecum|Interstitial|..|Vf (protein)" id="1496" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|Caecum|Interstitial|..|Vf (water)" id="1497" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|Caecum|Intracellular|C1|Concentration" id="1498" />
-          <Map s="S1|Neighborhoods|Caecum_int_Caecum_cell|C1|P*SA interstitial -&gt; intracellular" id="1499" />
-          <Map s="S1|Neighborhoods|Caecum_int_Caecum_cell|C1|P*SA intracellular -&gt; interstitial" id="1500" />
-          <Map s="S1|Organism|Lumen|Caecum|Effective surface area enhancement factor" id="1501" />
-          <Map s="S1|Organism|Lumen|Caecum|Geometric surface area" id="1502" />
-          <Map s="S1|Organism|Lumen|Caecum|Microvilli factor" id="1503" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|ColonAscendens|BloodCells|C1|Concentration" id="1504" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|ColonAscendens|Plasma|C1|Concentration" id="1505" />
-          <Map s="S1|Neighborhoods|ColonAscendens_pls_ColonAscendens_bc|Surface area (blood cells/plasma)" id="1506" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|ColonAscendens|Plasma|..|Fraction vascular" id="1507" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|ColonAscendens|Plasma|..|Volume" id="1508" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|ColonAscendens|Interstitial|..|Vf (lipid)" id="1509" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|ColonAscendens|Interstitial|..|Vf (protein)" id="1510" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|ColonAscendens|Interstitial|..|Vf (water)" id="1511" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|C1|Concentration" id="1512" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|ColonAscendens|Interstitial|C1|Concentration" id="1513" />
-          <Map s="S1|Neighborhoods|ColonAscendens_int_ColonAscendens_cell|C1|P*SA interstitial -&gt; intracellular" id="1514" />
-          <Map s="S1|Neighborhoods|ColonAscendens_int_ColonAscendens_cell|C1|P*SA intracellular -&gt; interstitial" id="1515" />
-          <Map s="S1|Organism|Lumen|ColonAscendens|Effective surface area enhancement factor" id="1516" />
-          <Map s="S1|Organism|Lumen|ColonAscendens|Geometric surface area" id="1517" />
-          <Map s="S1|Organism|Lumen|ColonAscendens|Microvilli factor" id="1518" />
-          <Map s="S1|Neighborhoods|ColonAscendens_pls_ColonAscendens_int|C1|P (plasma&lt;-&gt;interstitial)" id="1519" />
-          <Map s="S1|Neighborhoods|ColonAscendens_pls_ColonAscendens_int|C1|Partition coefficient (interstitial/plasma)" id="1520" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|ColonTransversum|Interstitial|..|Vf (lipid)" id="1521" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|ColonTransversum|Interstitial|..|Vf (protein)" id="1522" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|ColonTransversum|Interstitial|..|Vf (water)" id="1523" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|C1|Concentration" id="1524" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|ColonTransversum|Interstitial|C1|Concentration" id="1525" />
-          <Map s="S1|Neighborhoods|ColonTransversum_int_ColonTransversum_cell|C1|P*SA interstitial -&gt; intracellular" id="1526" />
-          <Map s="S1|Neighborhoods|ColonTransversum_int_ColonTransversum_cell|C1|P*SA intracellular -&gt; interstitial" id="1527" />
-          <Map s="S1|Organism|Lumen|ColonTransversum|Effective surface area enhancement factor" id="1528" />
-          <Map s="S1|Organism|Lumen|ColonTransversum|Geometric surface area" id="1529" />
-          <Map s="S1|Organism|Lumen|ColonTransversum|Microvilli factor" id="1530" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|ColonTransversum|BloodCells|C1|Concentration" id="1531" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|ColonTransversum|Plasma|C1|Concentration" id="1532" />
-          <Map s="S1|Neighborhoods|ColonTransversum_pls_ColonTransversum_bc|Surface area (blood cells/plasma)" id="1533" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|ColonTransversum|Plasma|..|Fraction vascular" id="1534" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|ColonTransversum|Plasma|..|Volume" id="1535" />
-          <Map s="S1|Neighborhoods|ColonTransversum_pls_ColonTransversum_int|C1|P (plasma&lt;-&gt;interstitial)" id="1536" />
-          <Map s="S1|Neighborhoods|ColonTransversum_pls_ColonTransversum_int|C1|Partition coefficient (interstitial/plasma)" id="1537" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|ColonDescendens|Interstitial|C1|Concentration" id="1538" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|ColonDescendens|Plasma|C1|Concentration" id="1539" />
-          <Map s="S1|Neighborhoods|ColonDescendens_pls_ColonDescendens_int|C1|P (plasma&lt;-&gt;interstitial)" id="1540" />
-          <Map s="S1|Neighborhoods|ColonDescendens_pls_ColonDescendens_int|C1|Partition coefficient (interstitial/plasma)" id="1541" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|ColonDescendens|Plasma|..|Fraction vascular" id="1542" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|ColonDescendens|Plasma|..|Volume" id="1543" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|ColonDescendens|BloodCells|C1|Concentration" id="1544" />
-          <Map s="S1|Neighborhoods|ColonDescendens_pls_ColonDescendens_bc|Surface area (blood cells/plasma)" id="1545" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|ColonDescendens|Interstitial|..|Vf (lipid)" id="1546" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|ColonDescendens|Interstitial|..|Vf (protein)" id="1547" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|ColonDescendens|Interstitial|..|Vf (water)" id="1548" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|C1|Concentration" id="1549" />
-          <Map s="S1|Neighborhoods|ColonDescendens_int_ColonDescendens_cell|C1|P*SA interstitial -&gt; intracellular" id="1550" />
-          <Map s="S1|Neighborhoods|ColonDescendens_int_ColonDescendens_cell|C1|P*SA intracellular -&gt; interstitial" id="1551" />
-          <Map s="S1|Organism|Lumen|ColonDescendens|Effective surface area enhancement factor" id="1552" />
-          <Map s="S1|Organism|Lumen|ColonDescendens|Geometric surface area" id="1553" />
-          <Map s="S1|Organism|Lumen|ColonDescendens|Microvilli factor" id="1554" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|ColonSigmoid|Interstitial|C1|Concentration" id="1555" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|ColonSigmoid|Plasma|C1|Concentration" id="1556" />
-          <Map s="S1|Neighborhoods|ColonSigmoid_pls_ColonSigmoid_int|C1|P (plasma&lt;-&gt;interstitial)" id="1557" />
-          <Map s="S1|Neighborhoods|ColonSigmoid_pls_ColonSigmoid_int|C1|Partition coefficient (interstitial/plasma)" id="1558" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|ColonSigmoid|Plasma|..|Fraction vascular" id="1559" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|ColonSigmoid|Plasma|..|Volume" id="1560" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|ColonSigmoid|BloodCells|C1|Concentration" id="1561" />
-          <Map s="S1|Neighborhoods|ColonSigmoid_pls_ColonSigmoid_bc|Surface area (blood cells/plasma)" id="1562" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|ColonSigmoid|Interstitial|..|Vf (lipid)" id="1563" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|ColonSigmoid|Interstitial|..|Vf (protein)" id="1564" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|ColonSigmoid|Interstitial|..|Vf (water)" id="1565" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|C1|Concentration" id="1566" />
-          <Map s="S1|Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|C1|P*SA interstitial -&gt; intracellular" id="1567" />
-          <Map s="S1|Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|C1|P*SA intracellular -&gt; interstitial" id="1568" />
-          <Map s="S1|Organism|Lumen|ColonSigmoid|Effective surface area enhancement factor" id="1569" />
-          <Map s="S1|Organism|Lumen|ColonSigmoid|Geometric surface area" id="1570" />
-          <Map s="S1|Organism|Lumen|ColonSigmoid|Microvilli factor" id="1571" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|Rectum|Interstitial|C1|Concentration" id="1572" />
-          <Map s="S1|Neighborhoods|Rectum_pls_Rectum_int|C1|P (plasma&lt;-&gt;interstitial)" id="1573" />
-          <Map s="S1|Neighborhoods|Rectum_pls_Rectum_int|C1|Partition coefficient (interstitial/plasma)" id="1574" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|Rectum|Plasma|..|Fraction vascular" id="1575" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|Rectum|Plasma|..|Volume" id="1576" />
-          <Map s="S1|Neighborhoods|Rectum_pls_Rectum_bc|Surface area (blood cells/plasma)" id="1577" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|Rectum|Interstitial|..|Vf (lipid)" id="1578" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|Rectum|Interstitial|..|Vf (protein)" id="1579" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|Rectum|Interstitial|..|Vf (water)" id="1580" />
-          <Map s="S1|Neighborhoods|Rectum_int_Rectum_cell|C1|P*SA interstitial -&gt; intracellular" id="1581" />
-          <Map s="S1|Neighborhoods|Rectum_int_Rectum_cell|C1|P*SA intracellular -&gt; interstitial" id="1582" />
-          <Map s="S1|Organism|Lumen|Rectum|Microvilli factor" id="1583" />
-          <Map s="S1|Neighborhoods|Caecum_bc_PortalVein_bc|C1|Mass transfer rate (mucosa to portal vein blood cells)" id="1584" />
-          <Map s="S1|Organism|Lumen|Caecum|Liquid" id="1585" />
-          <Map s="S1|Neighborhoods|Lumen_cae_Caecum_cell|C1|P_int_trans_cell_lum_factor" id="1586" />
-          <Map s="S1|Neighborhoods|Lumen_cae_Caecum_cell|C1|P_int_trans_lum_cell_factor" id="1587" />
-          <Map s="S1|Organism|Lumen|Caecum|C1|Solubility" id="1588" />
-          <Map s="S1|Organism|Lumen|Caecum|..|Transcellular absorption sink condition" id="1589" />
-          <Map s="S1|Neighborhoods|Caecum_int_Caecum_cell|C1|Partition coefficient (intracellular/plasma)" id="1590" />
-          <Map s="S1|Organism|Lumen|Caecum|pH" id="1591" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|Caecum|Intracellular|pH" id="1592" />
-          <Map s="S1|Neighborhoods|Lumen_cae_Caecum_cell|C1|DrugAbsorption_trans|ProcessRate" id="1593" />
-          <Map s="S1|Neighborhoods|Lumen_cae_Caecum_cell|C1|Drug absorption rate (lumen to mucosa)" id="1594" />
-          <Map s="S1|Organism|Lumen|Caecum|..|Paracellular absorption sink condition" id="1595" />
-          <Map s="S1|Neighborhoods|Caecum_pls_PortalVein_pls|C1|Mass transfer rate (mucosa to portal vein plasma)" id="1596" />
-          <Map s="S1|Organism|Lumen|ColonTransversum|Liquid" id="1597" />
-          <Map s="S1|Organism|Lumen|ColonTransversum|C1|Solubility" id="1598" />
-          <Map s="S1|Organism|Lumen|ColonTransversum|..|Paracellular absorption sink condition" id="1599" />
-          <Map s="S1|Neighborhoods|ColonAscendens_bc_PortalVein_bc|C1|Mass transfer rate (mucosa to portal vein blood cells)" id="1600" />
-          <Map s="S1|Neighborhoods|ColonAscendens_pls_PortalVein_pls|C1|Mass transfer rate (mucosa to portal vein plasma)" id="1601" />
-          <Map s="S1|Neighborhoods|ColonSigmoid_pls_PortalVein_pls|C1|Mass transfer rate (mucosa to portal vein plasma)" id="1602" />
-          <Map s="S1|Organism|Lumen|ColonSigmoid|Liquid" id="1603" />
-          <Map s="S1|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|C1|P_int_trans_cell_lum_factor" id="1604" />
-          <Map s="S1|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|C1|P_int_trans_lum_cell_factor" id="1605" />
-          <Map s="S1|Organism|Lumen|ColonSigmoid|C1|Solubility" id="1606" />
-          <Map s="S1|Organism|Lumen|ColonSigmoid|..|Transcellular absorption sink condition" id="1607" />
-          <Map s="S1|Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|C1|Partition coefficient (intracellular/plasma)" id="1608" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|pH" id="1609" />
-          <Map s="S1|Organism|Lumen|ColonSigmoid|pH" id="1610" />
-          <Map s="S1|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|C1|DrugAbsorption_trans|ProcessRate" id="1611" />
-          <Map s="S1|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|C1|Drug absorption rate (lumen to mucosa)" id="1612" />
-          <Map s="S1|Organism|Lumen|ColonSigmoid|..|Paracellular absorption sink condition" id="1613" />
-          <Map s="S1|Neighborhoods|ColonDescendens_bc_PortalVein_bc|C1|Mass transfer rate (mucosa to portal vein blood cells)" id="1614" />
-          <Map s="S1|Neighborhoods|ColonDescendens_pls_PortalVein_pls|C1|Mass transfer rate (mucosa to portal vein plasma)" id="1615" />
-          <Map s="S1|Neighborhoods|ColonSigmoid_bc_PortalVein_bc|C1|Mass transfer rate (mucosa to portal vein blood cells)" id="1616" />
-          <Map s="S1|Organism|Lumen|ColonDescendens|pH" id="1617" />
-          <Map s="S1|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|C1|DrugAbsorption_trans|ProcessRate" id="1618" />
-          <Map s="S1|Neighborhoods|ColonDescendens_int_ColonDescendens_cell|C1|Partition coefficient (intracellular/plasma)" id="1619" />
-          <Map s="S1|Organism|Lumen|ColonDescendens|Liquid" id="1620" />
-          <Map s="S1|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|C1|P_int_trans_cell_lum_factor" id="1621" />
-          <Map s="S1|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|C1|P_int_trans_lum_cell_factor" id="1622" />
-          <Map s="S1|Organism|Lumen|ColonDescendens|C1|Solubility" id="1623" />
-          <Map s="S1|Organism|Lumen|ColonDescendens|..|Transcellular absorption sink condition" id="1624" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|pH" id="1625" />
-          <Map s="S1|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|C1|Drug absorption rate (lumen to mucosa)" id="1626" />
-          <Map s="S1|Organism|Lumen|ColonDescendens|..|Paracellular absorption sink condition" id="1627" />
-          <Map s="S1|Neighborhoods|ColonTransversum_bc_PortalVein_bc|C1|Mass transfer rate (mucosa to portal vein blood cells)" id="1628" />
-          <Map s="S1|Neighborhoods|ColonTransversum_pls_PortalVein_pls|C1|Mass transfer rate (mucosa to portal vein plasma)" id="1629" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|pH" id="1630" />
-          <Map s="S1|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|C1|P_int_trans_cell_lum_factor" id="1631" />
-          <Map s="S1|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|C1|P_int_trans_lum_cell_factor" id="1632" />
-          <Map s="S1|Organism|Lumen|ColonTransversum|..|Transcellular absorption sink condition" id="1633" />
-          <Map s="S1|Neighborhoods|ColonTransversum_int_ColonTransversum_cell|C1|Partition coefficient (intracellular/plasma)" id="1634" />
-          <Map s="S1|Organism|Lumen|ColonTransversum|pH" id="1635" />
-          <Map s="S1|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|C1|DrugAbsorption_trans|ProcessRate" id="1636" />
-          <Map s="S1|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|C1|Drug absorption rate (lumen to mucosa)" id="1637" />
-          <Map s="S1|Organism|Lumen|ColonAscendens|pH" id="1638" />
-          <Map s="S1|Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|pH" id="1639" />
-          <Map s="S1|Organism|Lumen|ColonAscendens|Liquid" id="1640" />
-          <Map s="S1|Neighborhoods|Lumen_colasc_ColonAscendens_cell|C1|P_int_trans_cell_lum_factor" id="1641" />
-          <Map s="S1|Neighborhoods|Lumen_colasc_ColonAscendens_cell|C1|P_int_trans_lum_cell_factor" id="1642" />
-          <Map s="S1|Organism|Lumen|ColonAscendens|C1|Solubility" id="1643" />
-          <Map s="S1|Organism|Lumen|ColonAscendens|..|Transcellular absorption sink condition" id="1644" />
-          <Map s="S1|Neighborhoods|ColonAscendens_int_ColonAscendens_cell|C1|Partition coefficient (intracellular/plasma)" id="1645" />
-          <Map s="S1|Neighborhoods|Lumen_colasc_ColonAscendens_cell|C1|DrugAbsorption_trans|ProcessRate" id="1646" />
-          <Map s="S1|Neighborhoods|Lumen_colasc_ColonAscendens_cell|C1|Drug absorption rate (lumen to mucosa)" id="1647" />
-          <Map s="S1|Organism|Lumen|ColonAscendens|..|Paracellular absorption sink condition" id="1648" />
-          <Map s="S1|Neighborhoods|Duodenum_bc_PortalVein_bc|C1|Mass transfer rate (mucosa to portal vein blood cells)" id="1649" />
-          <Map s="S1|Neighborhoods|Duodenum_pls_PortalVein_pls|C1|Mass transfer rate (mucosa to portal vein plasma)" id="1650" />
-          <Map s="S1|Organism|Lumen|Duodenum|pH" id="1651" />
-          <Map s="S1|Neighborhoods|Lumen_duo_Duodenum_cell|C1|DrugAbsorption_trans|ProcessRate" id="1652" />
-          <Map s="S1|Organism|Lumen|Duodenum|Liquid" id="1653" />
-          <Map s="S1|Neighborhoods|Lumen_duo_Duodenum_cell|C1|P_int_trans_cell_lum_factor" id="1654" />
-          <Map s="S1|Neighborhoods|Lumen_duo_Duodenum_cell|C1|P_int_trans_lum_cell_factor" id="1655" />
-          <Map s="S1|Organism|Lumen|Duodenum|C1|Solubility" id="1656" />
-          <Map s="S1|Organism|Lumen|Duodenum|..|Transcellular absorption sink condition" id="1657" />
-          <Map s="S1|Neighborhoods|Duodenum_int_Duodenum_cell|C1|Partition coefficient (intracellular/plasma)" id="1658" />
-          <Map s="S1|Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|pH" id="1659" />
-          <Map s="S1|Neighborhoods|Lumen_duo_Duodenum_cell|C1|Drug absorption rate (lumen to mucosa)" id="1660" />
-          <Map s="S1|Organism|Lumen|Duodenum|..|Paracellular absorption sink condition" id="1661" />
-          <Map s="S1|Neighborhoods|Lumen_duo_Duodenum_pls|C1|DrugAbsorption_para|ProcessRate" id="1662" />
-          <Map s="S1|Neighborhoods|Lumen_duo_Duodenum_pls|C1|Drug absorption rate (lumen to mucosa)" id="1663" />
-          <Map s="S1|C1|Specific intestinal permeability (transcellular)" id="1664" />
-          <Map s="P_int_InVitro" id="1665" />
-          <Map s="..|Default Intestinal permeability (transcellular)" id="1666" />
-          <Map s="P_int_trans_default" id="1667" />
-          <Map s="..|Intestinal permeability (transcellular)" id="1668" />
-          <Map s="S1|C1|P_pls_bc_factor" id="1669" />
-          <Map s="P_pls_rbc_factor" id="1670" />
-          <Map s="S1|C1|Calculated specific intestinal permeability (transcellular)" id="1671" />
-          <Map s="S1|Organism|Vf (lipid, blood cells)" id="1672" />
-          <Map s="f_lipids_rbc" id="1673" />
-          <Map s="S1|Organism|Vf (protein,blood cells)" id="1674" />
-          <Map s="f_proteins_rbc" id="1675" />
-          <Map s="S1|Organism|Vf (water,blood cells)" id="1676" />
-          <Map s="f_water_rbc" id="1677" />
-          <Map s="S1|C1|P_bc_pls_factor" id="1678" />
-          <Map s="P_rbc_pls_factor" id="1679" />
-          <Map s="..|BP_AGP" id="1680" />
-          <Map s="Agp" id="1681" />
-          <Map s="..|BP_ALBUMIN" id="1682" />
-          <Map s="Albumin" id="1683" />
-          <Map s="..|Fraction unbound (plasma, reference value)" id="1684" />
-          <Map s="fu_ref" id="1685" />
-          <Map s="..|Plasma protein binding partner" id="1686" />
-          <Map s="BindingPartner" id="1687" />
-          <Map s="S1|Organism|Ontogeny factor (albumin)" id="1688" />
-          <Map s="AlbuminOntgenyFactor" id="1689" />
-          <Map s="S1|Organism|Ontogeny factor (alpha1-acid glycoprotein)" id="1690" />
-          <Map s="AgpOntogenyFactor" id="1691" />
-          <Map s="S1|Organism|Plasma protein scale factor" id="1692" />
-          <Map s="PlasmaProteinScaleFactor" id="1693" />
-          <Map s="LogP" id="1694" />
-          <Map s="..|Compound type 0" id="1695" />
-          <Map s="..|Compound type 1" id="1696" />
-          <Map s="..|CT_ACID" id="1697" />
-          <Map s="CT_ACID" id="1698" />
-          <Map s="..|pKa value 0" id="1699" />
-          <Map s="..|pKa value 1" id="1700" />
-          <Map s="..|pKa value 2" id="1701" />
-          <Map s="..|pKa_Acids_Count" id="1702" />
-          <Map s="pKa_Acids_Count" id="1703" />
-          <Map s="..|pKa_pH_WS_sol_F1" id="1704" />
-          <Map s="..|pKa_pH_WS_sol_F2" id="1705" />
-          <Map s="..|pKa_pH_WS_sol_F3" id="1706" />
-          <Map s="..|Is triprotic acid" id="1707" />
-          <Map s="IsTriproticAcid" id="1708" />
-          <Map s="..|pKa_Acid_0" id="1709" />
-          <Map s="pKa_Acid_0" id="1710" />
-          <Map s="..|pKa_Acid_2" id="1711" />
-          <Map s="pKa_Acid_2" id="1712" />
-          <Map s="..|Is triprotic base" id="1713" />
-          <Map s="IsTriproticBase" id="1714" />
-          <Map s="..|pKa_Base_0" id="1715" />
-          <Map s="pKa_Base_0" id="1716" />
-          <Map s="..|pKa_Base_2" id="1717" />
-          <Map s="pKa_Base_2" id="1718" />
-          <Map s="..|CT_BASE" id="1719" />
-          <Map s="CT_BASE" id="1720" />
-          <Map s="..|pKa_Bases_Count" id="1721" />
-          <Map s="pKa_Bases_Count" id="1722" />
-          <Map s="..|Compound type 2" id="1723" />
-          <Map s="..|pKa_pH_WS_sol_K1" id="1724" />
-          <Map s="..|pKa_pH_WS_sol_K2" id="1725" />
-          <Map s="..|pKa_pH_WS_sol_K3" id="1726" />
-          <Map s="..|pKa_pH_WS_sol_K4" id="1727" />
-          <Map s="..|pKa_pH_WS_sol_K5" id="1728" />
-          <Map s="..|pKa_pH_WS_sol_K6" id="1729" />
-          <Map s="..|pKa_pH_WS_sol_K7" id="1730" />
-          <Map s="..|pKa_pH_WS_sol_K8" id="1731" />
-          <Map s="..|Solubility gain per charge" id="1732" />
-          <Map s="..|pKa_ThreeBases_1" id="1733" />
-          <Map s="pKa_ThreeBases_1" id="1734" />
-          <Map s="..|pKa_TwoBases_1" id="1735" />
-          <Map s="pKa_TwoBases_1" id="1736" />
-          <Map s="CT_0" id="1737" />
-          <Map s="CT_1" id="1738" />
-          <Map s="CT_2" id="1739" />
-          <Map s="..|pKa_OneAcid_0" id="1740" />
-          <Map s="pKa_OneAcid_0" id="1741" />
-          <Map s="..|pKa_ThreeAcids_0" id="1742" />
-          <Map s="pKa_ThreeAcids_0" id="1743" />
-          <Map s="..|pKa_TwoAcids_0" id="1744" />
-          <Map s="pKa_TwoAcids_0" id="1745" />
-          <Map s="..|pKa_ThreeAcids_1" id="1746" />
-          <Map s="pKa_ThreeAcids_1" id="1747" />
-          <Map s="..|pKa_TwoAcids_1" id="1748" />
-          <Map s="pKa_TwoAcids_1" id="1749" />
-          <Map s="..|pKa_OneBase_0" id="1750" />
-          <Map s="pKa_OneBase_0" id="1751" />
-          <Map s="..|pKa_ThreeBases_0" id="1752" />
-          <Map s="pKa_ThreeBases_0" id="1753" />
-          <Map s="..|pKa_TwoBases_0" id="1754" />
-          <Map s="pKa_TwoBases_0" id="1755" />
-          <Map s="..|CT_NEUTRAL" id="1756" />
-          <Map s="..|Reference pH" id="1757" />
-          <Map s="..|Br" id="1758" />
-          <Map s="Br" id="1759" />
-          <Map s="..|Cl" id="1760" />
-          <Map s="Cl" id="1761" />
-          <Map s="..|F" id="1762" />
-          <Map s="F" id="1763" />
-          <Map s="..|I" id="1764" />
-          <Map s="I" id="1765" />
-          <Map s="..|Molecular weight" id="1766" />
-          <Map s="..|Effective molecular weight" id="1767" />
-          <Map s="MWEff" id="1768" />
-          <Map s="..|Is small molecule" id="1769" />
-          <Map s="IsSmallMolecule" id="1770" />
-          <Map s="..|Lipophilicity" id="1771" />
-          <Map s="Chlor" id="1772" />
-          <Map s="..|Tablet_Location" id="1773" />
-          <Map s="location" id="1774" />
-          <Map s="..|Tablet time delay factor" id="1775" />
-          <Map s="w_fact" id="1776" />
-          <Map s="..|Tablet_Location_cae" id="1777" />
-          <Map s="location_cae" id="1778" />
-          <Map s="..|Tablet_Location_colasc" id="1779" />
-          <Map s="location_colasc" id="1780" />
-          <Map s="..|Tablet_Location_coldesc" id="1781" />
-          <Map s="location_coldesc" id="1782" />
-          <Map s="..|Tablet_Location_colsigm" id="1783" />
-          <Map s="location_colsigm" id="1784" />
-          <Map s="..|Tablet_Location_coltrans" id="1785" />
-          <Map s="location_coltrans" id="1786" />
-          <Map s="..|Tablet_Location_duo" id="1787" />
-          <Map s="location_duo" id="1788" />
-          <Map s="..|Tablet_Location_lil" id="1789" />
-          <Map s="location_lil" id="1790" />
-          <Map s="..|Tablet_Location_lje" id="1791" />
-          <Map s="location_lje" id="1792" />
-          <Map s="..|Tablet_Location_rect" id="1793" />
-          <Map s="location_rect" id="1794" />
-          <Map s="..|Tablet_Location_sto" id="1795" />
-          <Map s="location_sto" id="1796" />
-          <Map s="..|Tablet_Location_uil" id="1797" />
-          <Map s="location_uil" id="1798" />
-          <Map s="..|Tablet_Location_uje" id="1799" />
-          <Map s="location_uje" id="1800" />
-          <Map s="..|TabletIsActive" id="1801" />
-          <Map s="TabletIsActive" id="1802" />
-          <Map s="..|ProtocolSchemaItem|Start time" id="1803" />
-          <Map s="S1|Organism|Lumen|Stomach|GET of non-disintegrated moiety" id="1804" />
-          <Map s="LagTime" id="1805" />
-          <Map s="w_sto" id="1806" />
-          <Map s="FillLevelFlag_duo" id="1807" />
-          <Map s="w_duo" id="1808" />
-          <Map s="FillLevelFlag_uje" id="1809" />
-          <Map s="w_uje" id="1810" />
-          <Map s="FillLevelFlag_lje" id="1811" />
-          <Map s="w_lje" id="1812" />
-          <Map s="FillLevelFlag_uil" id="1813" />
-          <Map s="w_uil" id="1814" />
-          <Map s="FillLevelFlag_lil" id="1815" />
-          <Map s="w_lil" id="1816" />
-          <Map s="FillLevelFlag_cae" id="1817" />
-          <Map s="w_cae" id="1818" />
-          <Map s="FillLevelFlag_colasc" id="1819" />
-          <Map s="w_colasc" id="1820" />
-          <Map s="FillLevelFlag_coltrans" id="1821" />
-          <Map s="w_coltrans" id="1822" />
-          <Map s="FillLevelFlag_coldesc" id="1823" />
-          <Map s="w_coldesc" id="1824" />
-          <Map s="FillLevelFlag_colsigm" id="1825" />
-          <Map s="w_colsigm" id="1826" />
-          <Map s="FillLevelFlag_rect" id="1827" />
-          <Map s="w_rect" id="1828" />
-          <Map s="..|..|ProtocolSchemaItem|DrugMass" id="1829" />
-          <Map s="DrugMass" id="1830" />
-          <Map s="..|..|ProtocolSchemaItem|Amount of water" id="1831" />
-          <Map s="Water" id="1832" />
-          <Map s="Tablet_Location" id="1833" />
-          <Map s="..|Dose" id="1834" />
-          <Map s="Dose" id="1835" />
-          <Map s="..|DosePerBodyWeight" id="1836" />
-          <Map s="DosePerBodyWeight" id="1837" />
-          <Map s="Dose per body weight" id="1838" />
-          <Map s="..|Volume of water/body weight" id="1839" />
-          <Map s="AmountOfWaterPerBodyWeight" id="1840" />
-          <Map s="Volume per body weight" id="1841" />
-          <Map s="..|C1" id="1842" />
-          <Map s="BinDrugMassSolid" id="1843" />
-          <Map s="..|InsolubleDrug|C1" id="1844" />
-          <Map s="BinDrugMassInsoluble" id="1845" />
-          <Map s="..|DrugMass of particle bin" id="1846" />
-          <Map s="BinDrugMass" id="1847" />
-          <Map s="..|Fraction insoluble" id="1848" />
-          <Map s="FractionInsoluble" id="1849" />
-          <Map s="..|Fraction solid" id="1850" />
-          <Map s="FractionSolid" id="1851" />
-          <Map s="..|Number of particles" id="1852" />
-          <Map s="N" id="1853" />
-          <Map s="..|Particle radius (at t=0)" id="1854" />
-          <Map s="r0" id="1855" />
-          <Map s="S1|C1|Density (drug)" id="1856" />
-          <Map s="DrugDensity" id="1857" />
-          <Map s="..|Number_Of_Particles_Factor" id="1858" />
-          <Map s="Number_Of_Particles_Factor" id="1859" />
-          <Map s="Inversed volume" id="1860" />
-          <Map s="..|..|..|Tablet_Location_cae" id="1861" />
-          <Map s="Tablet_Location_cae" id="1862" />
-          <Map s="..|..|..|Tablet_Location_colasc" id="1863" />
-          <Map s="Tablet_Location_colasc" id="1864" />
-          <Map s="..|..|..|Tablet_Location_coldesc" id="1865" />
-          <Map s="Tablet_Location_coldesc" id="1866" />
-          <Map s="..|..|..|Tablet_Location_colsigm" id="1867" />
-          <Map s="Tablet_Location_colsigm" id="1868" />
-          <Map s="..|..|..|Tablet_Location_coltrans" id="1869" />
-          <Map s="Tablet_Location_coltrans" id="1870" />
-          <Map s="..|..|..|Tablet_Location_duo" id="1871" />
-          <Map s="Tablet_Location_duo" id="1872" />
-          <Map s="..|..|..|Tablet_Location_lil" id="1873" />
-          <Map s="Tablet_Location_lil" id="1874" />
-          <Map s="..|..|..|Tablet_Location_lje" id="1875" />
-          <Map s="Tablet_Location_lje" id="1876" />
-          <Map s="..|..|..|Tablet_Location_rect" id="1877" />
-          <Map s="Tablet_Location_rect" id="1878" />
-          <Map s="..|..|..|Tablet_Location_sto" id="1879" />
-          <Map s="Tablet_Location_sto" id="1880" />
-          <Map s="..|..|..|Tablet_Location_uil" id="1881" />
-          <Map s="Tablet_Location_uil" id="1882" />
-          <Map s="..|..|..|Tablet_Location_uje" id="1883" />
-          <Map s="Tablet_Location_uje" id="1884" />
-          <Map s="rho" id="1885" />
-          <Map s="S1|C1|Immediately dissolve particles smaller than" id="1886" />
-          <Map s="ParticleRadiusDissolved" id="1887" />
-          <Map s="..|..|..|..|DrugMass of particle bin" id="1888" />
-          <Map s="X0" id="1889" />
-          <Map s="..|..|..|..|Particle radius (at t=0)" id="1890" />
-          <Map s="..|..|..|..|..|..|Thickness (unstirred water layer)" id="1891" />
-          <Map s="h" id="1892" />
-          <Map s="S1|C1|Aqueous diffusion coefficient" id="1893" />
-          <Map s="D" id="1894" />
-          <Map s="Diffusion coefficient" id="1895" />
-          <Map s="..|..|..|..|C1" id="1896" />
-          <Map s="X" id="1897" />
-          <Map s="S" id="1898" />
-          <Map s="S1|C1|Treat precipitated drug as" id="1899" />
-          <Map s="PrecipitatedDrugSoluble" id="1900" />
-          <Map s="..|..|..|..|Tablet_Location_cae" id="1901" />
-          <Map s="..|..|..|..|TabletIsActive" id="1902" />
-          <Map s="Precipitation rate of the tablet" id="1903" />
-          <Map s="ParticlesPrecipitationRate" id="1904" />
-          <Map s="..|..|..|..|Tablet_Location_colasc" id="1905" />
-          <Map s="..|..|..|..|Tablet_Location_coldesc" id="1906" />
-          <Map s="..|..|..|..|Tablet_Location_colsigm" id="1907" />
-          <Map s="..|..|..|..|Tablet_Location_coltrans" id="1908" />
-          <Map s="..|..|..|..|Tablet_Location_duo" id="1909" />
-          <Map s="..|..|..|..|Tablet_Location_lil" id="1910" />
-          <Map s="..|..|..|..|Tablet_Location_lje" id="1911" />
-          <Map s="..|..|..|..|Tablet_Location_rect" id="1912" />
-          <Map s="S1|Organism|Lumen|Stomach|C1|Solubility" id="1913" />
-          <Map s="..|..|..|..|Tablet_Location_sto" id="1914" />
-          <Map s="..|..|..|..|Tablet_Location_uil" id="1915" />
-          <Map s="..|..|..|..|Tablet_Location_uje" id="1916" />
-          <Map s="..|..|..|DrugMass of particle bin" id="1917" />
-          <Map s="..|..|..|Particle radius (at t=0)" id="1918" />
-          <Map s="..|..|..|..|..|Thickness (unstirred water layer)" id="1919" />
-          <Map s="..|.." id="1920" />
-          <Map s="..|..|..|TabletIsActive" id="1921" />
-          <Map s="Release rate of the tablet" id="1922" />
-          <Map s="TabletReleaseRate" id="1923" />
-          <Map s="ParticleBinDrugMass" id="1924" />
-          <Map s="S1|Applications|Particles|Application_1|ProtocolSchemaItem|DrugMass" id="1925" />
-          <Map s="M_1" id="1926" />
-        </StringMap>
-      </FormulaCache>
-    </Model>
-  </Simulation>
-</SimulationTransfer>
\ No newline at end of file
diff --git a/tests/MoBi.Tests/TestFiles/EB_LV.mbp3 b/tests/MoBi.Tests/TestFiles/EB_LV.mbp3
index f767354b0..15da86855 100644
Binary files a/tests/MoBi.Tests/TestFiles/EB_LV.mbp3 and b/tests/MoBi.Tests/TestFiles/EB_LV.mbp3 differ
diff --git a/tests/MoBi.Tests/TestFiles/Events.pkml b/tests/MoBi.Tests/TestFiles/Events.pkml
index 875b5e7f2..2ef7a80a6 100644
--- a/tests/MoBi.Tests/TestFiles/Events.pkml
+++ b/tests/MoBi.Tests/TestFiles/Events.pkml
@@ -1,9 +1,10 @@
 <?xml version="1.0" encoding="utf-8"?>
-<EventGroupBuildingBlock id="fcc6eade-3812-4406-a0ec-282df785a4a0" name="10 mg IV labeled and 10mg IV unlabeled" version="2">
+<EventGroupBuildingBlock id="xLKzGmJg9UOV--ilcwgK3A" name="10 mg IV labeled and 10mg IV unlabeled" icon="EventGroup" bbVersion="0" version="13">
+  <Creation createdAt="5248846133010497221" createdBy="Michael" creationMode="New" origin="Other" />
   <Builders>
-    <EventGroupBuilder id="2981cbbd-88ae-4567-a459-569fc090472c" name="Applications" icon="Applications" mode="Logical" containerType="Other">
+    <EventGroupBuilder id="5ELk7eoP1kuU0FlRdS9n7Q" name="Applications" icon="Applications" mode="Logical" containerType="Other">
       <Children>
-        <ApplicationBuilder id="750b51c8-f2d8-4df5-853a-bd6958f91097" name="Application_1" icon="Intravenous" mode="Logical" containerType="Other" eventGroupType="Intravenous" moleculeName="MK-7009_labeled">
+        <ApplicationBuilder id="_ZpE5iQxiE2c8wVXiZeHPw" name="Application_1" icon="Intravenous" mode="Logical" containerType="Application" eventGroupType="Intravenous" moleculeName="MK-7009_labeled">
           <Tags>
             <Tag value="Intravenous" />
             <Tag value="Application" />
@@ -11,52 +12,62 @@
             <Tag value="ApplicationRoot" />
           </Tags>
           <Children>
-            <Parameter id="609f6e1c-d6cf-42a0-a0eb-c641e49106fd" name="Application rate" description="Application rate" persistable="0" isFixedValue="0" formula="5d993bc0-41b9-4460-a715-463639bdb265" dim="Rate" quantityType="0" visible="0" canBeVaried="1" />
-            <EventBuilder id="7a25814e-1680-4fff-b4a2-f26ff9b0d984" name="Application_StartEvent" description="Start event for application" oneTime="1" dimension="Dimensionless" formula="19bc8b7a-4394-4926-9f36-cfb4f72998fa">
+            <Parameter id="hvbrSGkGYUKlrkHjf_o2Aw" name="Application rate" description="Application rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0" displayUnit="µmol/min">
+              <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+            </Parameter>
+            <EventBuilder id="wQQj2KZpNkKqYM64acopWA" name="Application_StartEvent" description="Start event for application" oneTime="1" formula="kejCELd2IEaPujTR78ClWg">
               <Tags>
                 <Tag value="Application" />
                 <Tag value="Application_1" />
               </Tags>
               <Assignments>
-                <EventAssignmentBuilder id="d42d27c5-9546-4c95-b833-d4d4de3f9316" name="Assignment_1" useAsValue="0" dimension="Dimensionless" formula="9f8719b2-4f13-40ad-a218-066d3d523a9a">
+                <EventAssignmentBuilder id="q8i0KeZrpEG9mR0EZ_4ePw" name="Assignment_1" useAsValue="0" formula="YRjAiG2Qvk-vnaxcwrxwsA">
                   <ObjectPath path="0" />
                 </EventAssignmentBuilder>
               </Assignments>
             </EventBuilder>
-            <EventBuilder id="874edab5-0a25-40ac-bc08-9e59e74e12af" name="Application_StopEvent" description="Stop event for application" oneTime="1" dimension="Dimensionless" formula="98aa6f8f-2538-49a4-81b4-6e83c9f61869">
+            <EventBuilder id="z_uNpE32mUq3aGduRxrYkw" name="Application_StopEvent" description="Stop event for application" oneTime="1" formula="fHLOX9m5UkqmLf1CRNRSsQ">
               <Tags>
                 <Tag value="Application" />
                 <Tag value="Application_1" />
               </Tags>
               <Assignments>
-                <EventAssignmentBuilder id="c9071b8f-3d9e-4cd8-8f04-094708d338c7" name="Assignment_1" useAsValue="0" dimension="Dimensionless" formula="f804a75a-e017-4a0b-afac-d2e6323def38">
+                <EventAssignmentBuilder id="KoX7or0AlEqxwR8V2r5Azw" name="Assignment_1" useAsValue="0" formula="qhzWya-IO0WqZpOGgs3s2A">
                   <ObjectPath path="0" />
                 </EventAssignmentBuilder>
               </Assignments>
             </EventBuilder>
-            <Container id="f4fb0a00-120f-48df-94b8-f4fab38e2df0" name="ProtocolSchemaItem" description="Protocol Schema Item" mode="Logical" containerType="Other">
+            <Container id="1LcyLQOQdU2SqTJ1yYcXuw" name="ProtocolSchemaItem" description="Protocol Schema Item" mode="Logical" containerType="Other">
               <Tags>
                 <Tag value="ProtocolSchemaItem" />
                 <Tag value="Application" />
                 <Tag value="Application_1" />
               </Tags>
               <Children>
-                <Parameter id="11bb569d-0c8f-4857-be18-637c23484224" name="Start time" description="Start time of application" persistable="0" isFixedValue="0" formula="8a8dbe9c-6de2-48d1-9b93-90293b2b957a" dim="Time" quantityType="0" visible="0" canBeVaried="1" />
-                <Parameter id="35ca9e4a-500e-474f-9a45-b32aae77069d" name="DosePerBodyWeight" description="Dose" persistable="0" isFixedValue="0" formula="63388841-73db-4ebf-b1c4-513783162d3b" dim="DosePerBodyWeight" quantityType="0" visible="0" canBeVaried="1" />
-                <Parameter id="52c1cbe0-23d6-444e-979c-23b7d05fada0" name="InputDose" description="Dose" persistable="0" isFixedValue="0" formula="169a9483-566b-49e3-b4c1-4f28ef3cc082" dim="DosePerBodyWeight" quantityType="0" visible="0" canBeVaried="1" />
-                <Parameter id="bb2fa321-0b76-46c0-84a2-4858096c09f2" name="DrugMass" description="Drug mass of application" persistable="0" isFixedValue="0" formula="a961ee51-4c1d-4e73-a649-a388ec690084" dim="Amount" quantityType="0" visible="0" canBeVaried="1" />
-                <Parameter id="facd244e-8cd5-40ef-a43d-c76130c9a018" name="Dose" description="Dose" persistable="0" isFixedValue="0" formula="37054909-bf2d-4750-b503-7c1aa421f37a" dim="MassAmount" quantityType="0" visible="0" canBeVaried="1" />
-                <Parameter id="7e9c6b4d-0825-4a56-9248-80e13f0ff18b" name="Infusion time" description="Infusion time of intravenous infusion" persistable="0" isFixedValue="0" formula="7f80542b-cc27-470c-9e62-7723dedf66c9" dim="Time" quantityType="0" visible="0" canBeVaried="1" />
+                <Parameter id="ftgwwcqBOE2s887SDcxG1g" name="Start time" description="Start time of application" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0" displayUnit="h">
+                  <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+                </Parameter>
+                <Parameter id="-Bs3vGRgt0e_6Iz8UVn9YA" name="DosePerBodyWeight" description="Dose" icon="Parameter" persistable="0" isFixedValue="0" dim="Dose per body weight" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1E-06" displayUnit="kg/kg">
+                  <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+                </Parameter>
+                <Parameter id="61HsDC0RDk6VBnfA2JUxCA" name="InputDose" description="Dose" icon="Parameter" persistable="0" isFixedValue="0" dim="Dose per body weight" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1E-05" displayUnit="kg/kg">
+                  <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+                </Parameter>
+                <Parameter id="4zER_jv40kSF8xR64xXnAw" name="DrugMass" description="Drug mass of application" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" formula="UlVUjCO2YkqZqQfACdP0-g" isDefault="1" displayUnit="µmol">
+                  <Tags>
+                    <Tag value="MOLECULE" />
+                  </Tags>
+                  <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+                </Parameter>
+                <Parameter id="URfcgVELp0Oy0I5RzUb01g" name="Dose" description="Dose" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1E-05" displayUnit="kg">
+                  <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+                </Parameter>
+                <Parameter id="WYfv13f98k-yUj4CFZhMjQ" name="Infusion time" description="Infusion time of intravenous infusion" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="15" displayUnit="h">
+                  <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+                </Parameter>
               </Children>
             </Container>
-          </Children>
-          <SourceCriteria>
-            <DescriptorConditions>
-              <MatchTagCondition tag="Applications" />
-            </DescriptorConditions>
-          </SourceCriteria>
-          <Transports>
-            <TransportBuilder id="aaf4f26c-e126-47ad-9e4f-639cc4f7683f" name="Intravenous_Transport" dimension="Dimensionless" createProcessRateParameter="0" formula="f682dc59-d36c-4bb1-b27c-1f917d55ac9a" transportType="Efflux">
+            <TransportBuilder id="JomgDAGESEupod-whKqlCw" name="Intravenous_Transport" mode="Logical" containerType="Other" createProcessRateParameter="0" processRateParameterPersistable="0" formula="sCXLcPGn1EyB6Sdc86852w" transportType="Efflux">
               <SourceCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="Application" />
@@ -70,15 +81,18 @@
                   <MatchTagCondition tag="VenousBlood" />
                 </DescriptorConditions>
               </TargetCriteria>
+              <MoleculeList forAll="1" />
             </TransportBuilder>
-          </Transports>
-          <MoleculeNames>
-            <ApplicationMoleculeBuilder id="51ce0039-f7dc-44f8-8790-9e7979438971" formula="1ec1894d-99f3-4334-bd98-201db85f57d3">
+            <ApplicationMoleculeBuilder id="NZb5FpNJcECqUjm6HkQr0Q" formula="S0s8Dte6LEGXKYR1QzOeig">
               <RelativeContainerPath path="1" />
             </ApplicationMoleculeBuilder>
-          </MoleculeNames>
+          </Children>
+          <SourceCriteria>
+            <DescriptorConditions>
+              <MatchTagCondition tag="Applications" />
+            </DescriptorConditions>
+          </SourceCriteria>
         </ApplicationBuilder>
-        <Parameter id="a0c60f91-762d-4455-9d71-d6ec531aba43" name="TotalDrugMass" persistable="0" isFixedValue="0" formula="5cffd833-220a-4553-a3b2-3cf6cf967d4d" dim="Amount" quantityType="0" visible="0" canBeVaried="1" />
       </Children>
       <SourceCriteria>
         <DescriptorConditions>
@@ -89,54 +103,48 @@
   </Builders>
   <FormulaCache>
     <Formulas>
-      <Formula id="9f8719b2-4f13-40ad-a218-066d3d523a9a" name="ApplicationRate_Intravenous" dim="Rate" formula="DrugMass/InfusionTime">
+      <Formula id="YRjAiG2Qvk-vnaxcwrxwsA" name="ApplicationRate_Intravenous" dim="Amount per time" formula="DrugMass/InfusionTime">
         <Paths>
           <Path path="2" as="3" dim="4" />
           <Path path="5" as="6" dim="7" />
           <TimePath />
         </Paths>
       </Formula>
-      <Formula id="19bc8b7a-4394-4926-9f36-cfb4f72998fa" name="AppStartEventCondition" dim="Dimensionless" formula="Time=StartTime">
+      <Formula id="kejCELd2IEaPujTR78ClWg" name="AppStartEventCondition" formula="Time=StartTime">
         <Paths>
           <Path path="8" as="9" dim="7" />
           <TimePath />
         </Paths>
       </Formula>
-      <Formula id="98aa6f8f-2538-49a4-81b4-6e83c9f61869" name="AppStopEventIVCondition" dim="Dimensionless" formula="Time=StartTime+InfusionTime">
+      <Formula id="fHLOX9m5UkqmLf1CRNRSsQ" name="AppStopEventIVCondition" formula="Time=StartTime+InfusionTime">
         <Paths>
           <Path path="10" as="6" dim="7" />
           <Path path="8" as="9" dim="7" />
           <TimePath />
         </Paths>
       </Formula>
-      <Formula id="a961ee51-4c1d-4e73-a649-a388ec690084" name="PARAM_Application_DrugMass" dim="Amount" formula="Dose / MW * 1000">
+      <Formula id="UlVUjCO2YkqZqQfACdP0-g" name="PARAM_Application_DrugMass" dim="Amount" formula="Dose / MW">
         <Paths>
           <Path path="11" as="12" dim="13" />
           <Path path="14" as="15" dim="16" />
         </Paths>
       </Formula>
-      <Formula id="f682dc59-d36c-4bb1-b27c-1f917d55ac9a" name="ApplicationTransportSimple" dim="Dimensionless" formula="ApplicationRate">
+      <Formula id="sCXLcPGn1EyB6Sdc86852w" name="ApplicationTransportSimple" formula="ApplicationRate">
         <Paths>
           <Path path="0" as="17" dim="18" />
         </Paths>
       </Formula>
-      <Formula id="1ec1894d-99f3-4334-bd98-201db85f57d3" dim="Dimensionless" formula="DrugMass">
+      <Formula id="S0s8Dte6LEGXKYR1QzOeig" formula="DrugMass">
         <Paths>
           <Path path="19" as="3" />
         </Paths>
       </Formula>
-      <Formula id="5cffd833-220a-4553-a3b2-3cf6cf967d4d" name="TotalDrugMass" dim="Amount" formula="M0">
+      <Formula id="BEaV0ahKzkS9Pd-6PWNG7g" name="TotalDrugMass" dim="Amount" formula="M0">
         <Paths>
           <Path path="20" as="21" dim="4" />
         </Paths>
       </Formula>
-      <ConstantFormula id="5d993bc0-41b9-4460-a715-463639bdb265" dim="Rate" value="0" />
-      <ConstantFormula id="f804a75a-e017-4a0b-afac-d2e6323def38" dim="Dimensionless" value="0" />
-      <ConstantFormula id="8a8dbe9c-6de2-48d1-9b93-90293b2b957a" dim="Dimensionless" value="0" />
-      <ConstantFormula id="63388841-73db-4ebf-b1c4-513783162d3b" dim="Dimensionless" value="1" />
-      <ConstantFormula id="169a9483-566b-49e3-b4c1-4f28ef3cc082" dim="Dimensionless" value="10" />
-      <ConstantFormula id="37054909-bf2d-4750-b503-7c1aa421f37a" dim="Dimensionless" value="10" />
-      <ConstantFormula id="7f80542b-cc27-470c-9e62-7723dedf66c9" dim="Dimensionless" value="15" />
+      <ConstantFormula id="qhzWya-IO0WqZpOGgs3s2A" value="0" />
     </Formulas>
     <StringMap>
       <Map s="..|..|Application rate" id="0" />
@@ -152,12 +160,12 @@
       <Map s="..|ProtocolSchemaItem|Infusion time" id="10" />
       <Map s="..|Dose" id="11" />
       <Map s="Dose" id="12" />
-      <Map s="MassAmount" id="13" />
+      <Map s="Mass" id="13" />
       <Map s="MOLECULE|Molecular weight" id="14" />
       <Map s="MW" id="15" />
-      <Map s="MolecularWeight" id="16" />
+      <Map s="Molecular weight" id="16" />
       <Map s="ApplicationRate" id="17" />
-      <Map s="Rate" id="18" />
+      <Map s="Amount per time" id="18" />
       <Map s="..|ProtocolSchemaItem|DrugMass" id="19" />
       <Map s="..|Application_1|ProtocolSchemaItem|DrugMass" id="20" />
       <Map s="M0" id="21" />
diff --git a/tests/MoBi.Tests/TestFiles/ManualModel_Sim.mbp3 b/tests/MoBi.Tests/TestFiles/ManualModel_Sim.mbp3
index 6e62c7b7e..f0b89effb 100644
Binary files a/tests/MoBi.Tests/TestFiles/ManualModel_Sim.mbp3 and b/tests/MoBi.Tests/TestFiles/ManualModel_Sim.mbp3 differ
diff --git a/tests/MoBi.Tests/TestFiles/MoBiSimulation3_4.pkml b/tests/MoBi.Tests/TestFiles/MoBiSimulation3_4.pkml
deleted file mode 100644
index 0e260c827..000000000
--- a/tests/MoBi.Tests/TestFiles/MoBiSimulation3_4.pkml
+++ /dev/null
@@ -1,41317 +0,0 @@
-<?xml version="1.0" encoding="utf-8" ?>
-<MoBiSimulation id="2TD4FTdlBkOVvx3M8nzQng" name="S1" parameterIdetificationWorkingDirectory="test" version="3">
-  <BuildConfiguration>
-    <Molecules id="Zfzv84-nK0KwsZ1OblVW4g" name="S1" bbVersion="0">
-      <Builders>
-        <MoleculeBuilder id="ElzX3nTi5EaLs-9BhrwtRQ" name="C1" icon="Drug" mode="Logical" containerType="Other" isFloating="1" quantityType="Drug" isXenobiotic="1" defaultStartFormula="npvUwCRrEk6fvvfOPA8xNw">
-          <Children>
-            <Parameter id="nVR382oNAky9EZcXw7mVWQ" name="pKa_TwoAcids_0" description="Smallest acid pKa for compound with 2 acid groups" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_TwoAcids_0" buildMode="Property" visible="0" canBeVaried="0" />
-            <Parameter id="FqzC6WUM5EiU9nwpzqXK7Q" name="pKa_pH_WS_sol_K2" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_K2" buildMode="Property" visible="0" canBeVaried="0" />
-            <Parameter id="UvfWCWHYI0eyNrRoIS2YXQ" name="pKa_pH_WS_sol_K3" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_K3" buildMode="Property" visible="0" canBeVaried="0" />
-            <Parameter id="yY1_amPMMkyg0VqwUK7bFw" name="pKa_pH_WS_sol_K4" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_K4" buildMode="Property" visible="0" canBeVaried="0" />
-            <Parameter id="82Yn63QUJ0OLJtfqp1BBOw" name="pKa_pH_WS_sol_K5" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_K5" buildMode="Property" visible="0" canBeVaried="0" />
-            <Parameter id="Bqu3DhHkwEqe3N6Fq7j--g" name="pKa_pH_WS_sol_K6" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_K6" buildMode="Property" visible="0" canBeVaried="0" />
-            <Parameter id="RWqknSlTBUW1_CyWuU9s5Q" name="pKa_pH_WS_sol_K7" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_K7" buildMode="Property" visible="0" canBeVaried="0" />
-            <Parameter id="xeK3uQDhe0eacYStN8okzw" name="pKa_pH_WS_sol_K8" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_K8" buildMode="Property" visible="0" canBeVaried="0" />
-            <Parameter id="ozuLsbLzmEKco4V23ZMMNg" name="pKa_ThreeAcids_0" description="Smallest acid pKa for compound with 3 acid groups" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_ThreeAcids_0" buildMode="Property" visible="0" canBeVaried="0" />
-            <Parameter id="0Yo5AWZpQkO__or00s45YA" name="pKa_ThreeAcids_1" description="Middle acid pKa for compound with 3 acid groups" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_ThreeAcids_1" buildMode="Property" visible="0" canBeVaried="0" />
-            <Parameter id="9ZVDl_KCQUy30sK_emGLZg" name="pKa_ThreeBases_1" description="Middle base pKa for compound with 3 base groups" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_ThreeBases_1" buildMode="Property" visible="0" canBeVaried="0" />
-            <Parameter id="JmdxQLZdT0-4ke8zdfwzSw" name="Total oral drug mass" description="Total oral drug mass" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" buildMode="Property" visible="0" canBeVaried="0" value="0" displayUnit="µmol" />
-            <Parameter id="UJFFX1yhEEKigxotxlD90w" name="pKa_TwoAcids_1" description="Middle acid pKa for compound with 2 acid groups" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_TwoAcids_1" buildMode="Property" visible="0" canBeVaried="0" />
-            <Parameter id="MnVWQqYRi0KIWRTwc9xNvA" name="pKa_TwoBases_0" description="Smallest base pKa for compound with 2 base groups" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_TwoBases_0" buildMode="Property" visible="0" canBeVaried="0" />
-            <Parameter id="1vmlXAkG90mcV_CSKWCXFA" name="pKa_TwoBases_1" description="Middle base pKa for compound with 2 base groups" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_TwoBases_1" buildMode="Property" visible="0" canBeVaried="0" />
-            <Parameter id="j10DYfg2aECQhcjbVflVVA" name="Plasma protein binding partner" description="Plasma protein to which the drug is predominantly bound. The ontogeny of the two most important plasma protein binding partners, albumin and α1-acid glycoprotein (AGP) is available in the PK-Sim database so that the fraction unbound in plasma can be scaled to children using the ontogeny of the respective protein. If  the binding partner is neither albumin nor AGP  or if scaling to children is not of interest, the third alternative (unknown) can be used. Please note that any other ontogeny can be uploaded for the scaling to children using the Population Simulation Toolbox in MoBi" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="0" value="1" />
-            <Parameter id="L2JGriQRWUmsNoePX4t0ow" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_RefpH_Factor" buildMode="Property" visible="0" canBeVaried="0" />
-            <Parameter id="x5Rck4aJVUmnrZYficu1mg" name="pKa_ThreeBases_0" description="Smallest base pKa for compound with 3 base groups" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_ThreeBases_0" buildMode="Property" visible="0" canBeVaried="0" />
-            <Parameter id="gnqe24JiL0u3KYXdCwdHJw" name="pKa_Base_1" description="Middle base pKa" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_Base_1" buildMode="Property" visible="0" canBeVaried="0" />
-            <Parameter id="n9wnTqW7JE2rmCPeMZO_rw" name="pKa_Bases_Count" description="Number of basic groups in compound" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_Bases_Count" buildMode="Property" visible="0" canBeVaried="0" />
-            <Parameter id="826veRLV9ESxP5sYPwJuyA" name="base_For_KaPL_Factor" description="Supporting parameter for calculation of pKa- and pH- dependent values of KaPL" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="0" canBeVaried="0" value="20" />
-            <Parameter id="8BJpqEA3cEaq4FQzsVS-hA" name="base_For_logD_Factor" description="Supporting parameter for calculation of pKa- and pH- dependent logD" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="0" canBeVaried="0" value="0.001" />
-            <Parameter id="jp_BcJJ5R0WCzbVnaUmJzQ" name="base_For_P_cell_Factor" description="Supporting parameter for calculation of pKa- and pH- dependent permeability to/from cells" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="0" canBeVaried="0" value="0.001" />
-            <Parameter id="NV8PJR-dEk6hIIETPHlrHA" name="BP_ALBUMIN" description="Constant for binding partner albumin" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="0" canBeVaried="0" value="1" />
-            <Parameter id="k8VA3KtmXkSEu5LXF2VmxQ" name="pKa value 2" description="pKa value" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="1" value="0" />
-            <Parameter id="kU4A58M59EuGxlikjU5glg" name="base_For_Pint_Factor" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="0" canBeVaried="0" value="0.1" />
-            <Parameter id="QeAe4mjrOEmF4YHLrOUCqg" name="Is strong base" description="Supporting parameter for partition coeffs in RR-Modell (at least one basic pKa&gt;=7)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_HasStrongBase" buildMode="Property" visible="0" canBeVaried="0" />
-            <Parameter id="XqXq1boyM0CUn8ozoNvFvg" name="Is triprotic acid" description="Is triprotic acid" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_IsTriproticAcid" buildMode="Property" visible="0" canBeVaried="0" />
-            <Parameter id="-udx0HDAhkOUztJOu1sw7Q" name="Is triprotic base" description="Is triprotic base" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_IsTriproticBase" buildMode="Property" visible="0" canBeVaried="0" />
-            <Parameter id="nMJWtMULGUuCv4Ci8rFufw" name="Molecular weight" description="Molecular weight" persistable="0" isFixedValue="0" dim="Molecular weight" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="1" value="4E-07" displayUnit="g/mol" />
-            <Parameter id="M-aHOxU5LECQnbyy8VeF6g" name="Is neutral" description="Supporting parameter for partition coeffs in RR-Modell" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_IsNeutral" buildMode="Property" visible="0" canBeVaried="0" />
-            <Parameter id="Vk_1D6ZeVUmLDz3bBe6mRA" name="pKa value 1" description="pKa value" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="1" value="0" />
-            <Parameter id="LnRFb3l1Q0Wdob36-owclw" name="Is monoprotic base monoprotic acid" description="Is monoprotic base monoprotic acid" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_IsMonoproticBaseMonoproticAcid" buildMode="Property" visible="0" canBeVaried="0" />
-            <Parameter id="jiXbZ1zRLEyU5w6gWCJK8g" name="pKa_Acid_0" description="Smallest acid pKa" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_Acid_0" buildMode="Property" visible="0" canBeVaried="0" />
-            <Parameter id="KJk2A3W7QE6iL0x9TtjcUA" name="pKa_Acid_1" description="Middle acid pKa" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_Acid_1" buildMode="Property" visible="0" canBeVaried="0" />
-            <Parameter id="idhYVT6u_k-Wzql3W3iqdQ" name="pKa_Acid_2" description="Largest acid pKa" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_Acid_2" buildMode="Property" visible="0" canBeVaried="0" />
-            <Parameter id="V3X9e2aep0uPd7i9SgEqww" name="pKa_Acids_Count" description="Number of acidic groups in compound" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_Acids_Count" buildMode="Property" visible="0" canBeVaried="0" />
-            <Parameter id="_k8KEN_0_kGUEEpENsuhMA" name="pKa_Base_0" description="Smallest base pKa" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_Base_0" buildMode="Property" visible="0" canBeVaried="0" />
-            <Parameter id="QFcHEU8TvkObesSkntRStQ" name="pKa_Base_2" description="Largest base pKa" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_Base_2" buildMode="Property" visible="0" canBeVaried="0" />
-            <Parameter id="DSf9umXY6US8znlVVMFQmA" name="pKa_OneAcid_0" description="Smallest acid pKa for compound with 1 acid group" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_OneAcid_0" buildMode="Property" visible="0" canBeVaried="0" />
-            <Parameter id="bVT90rwR-0aCmtAffDzspA" name="pKa_OneBase_0" description="Smallest base pKa for compound with 1 base group" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_OneBase_0" buildMode="Property" visible="0" canBeVaried="0" />
-            <Parameter id="h1eWOtwd00e6hDiAbcmHQQ" name="pKa_pH_WS_sol_F1" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_F1" buildMode="Property" visible="0" canBeVaried="0" />
-            <Parameter id="Y1n2tj5MIEWDNk8HEPw0Bg" name="pKa_pH_WS_sol_F2" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_F2" buildMode="Property" visible="0" canBeVaried="0" />
-            <Parameter id="ywFw5QpGNkaJl5BwvQuBGw" name="pKa_pH_WS_sol_F3" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_F3" buildMode="Property" visible="0" canBeVaried="0" />
-            <Parameter id="CI6UQXgzQEyW2RIgOX7wSA" name="pKa value 0" description="pKa value" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="1" value="0" />
-            <Parameter id="AGHsmIM6yUWv4--imKXKGA" name="Effective molecular weight" description="Effective molecular weight" persistable="0" isFixedValue="0" dim="Molecular weight" quantityType="Parameter" formula="CompoundMW_PKSim.PARAM_MWEff" buildMode="Property" visible="1" canBeVaried="0" displayUnit="g/mol" />
-            <Parameter id="G9GoxBKBX0CAdsoSf0y3FQ" name="pKa_pH_WS_sol_K1" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_K1" buildMode="Property" visible="0" canBeVaried="0" />
-            <Parameter id="DNRNd5PvbEC077EWWlwf6w" name="BP_UNKNOWN" description="Constant for binding partner unknown" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="0" canBeVaried="0" value="2" />
-            <Parameter id="3g-jSE1b_0qdGT0-zz9o6Q" name="Br" description="Number of bromine atoms in molecule" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="0" value="0" />
-            <Parameter id="N-BczFAGOkeESnmIDBWjPw" name="Calculated specific intestinal permeability (transcellular)" description="Calculated specific intestinal permeability (transcellular)" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_InVitro" buildMode="Global" visible="0" canBeVaried="0" displayUnit="cm/min" />
-            <Parameter id="ct_xIGQUQkGkBaC5QgHzGA" name="Cl" description="Number of chlorine atoms in molecule" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="0" value="0" />
-            <Parameter id="zoqsXHr-KkWqA5WIzb5yCg" name="Compound type 0" description="Compound type (-1: acid, +1: base, 0: neutral)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="0" value="0" />
-            <Parameter id="oTPfHVqN_EWUvCNl5svegQ" name="Compound type 1" description="Compound type (-1: acid, +1: base, 0: neutral)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="0" value="0" />
-            <Parameter id="SRhRE5bK2UKoGOslqP913Q" name="Compound type 2" description="Compound type (-1: acid, +1: base, 0: neutral)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="0" value="0" />
-            <Parameter id="odobRLnDtU-PtAC8uTsnMQ" name="CT_ACID" description="Constant for compound type acid" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="0" canBeVaried="0" value="-1" />
-            <Parameter id="7NsIPbUOoU6sTlUqCFOi2w" name="CT_BASE" description="Constant for compound type base" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="0" canBeVaried="0" value="1" />
-            <Parameter id="AEY0ZEbnM0mwe5c-NLk-hQ" name="Is small molecule" description="Treat compound as small molecule or not (if not, both organ specific and intestinal permeability will be set to zero)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="0" canBeVaried="0" value="1" />
-            <Parameter id="eL9j_tIee0OTbgcPMmItpg" name="BP_AGP" description="Constant for binding partner α1-acid glycoprotein" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="0" canBeVaried="0" value="0" />
-            <Parameter id="AvjS2jLDH0OaYTnsUPwWRA" name="F" description="Number of fluorine atoms in molecule" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="0" value="0" />
-            <Parameter id="ElNZymOMPUCKMnWt_Kxwgw" name="Has halogens" description="Supporting parameter for compound" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundMW_PKSim.PARAM_HasHalogens" buildMode="Property" visible="0" canBeVaried="0" />
-            <Parameter id="-49Hq_GS7Eq6pDovtpcofg" name="I" description="Number of iodine atoms in molecule" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="0" value="0" />
-            <Parameter id="8kW90BOCUESKgtOriFxaeA" name="Is diprotic acid" description="Is diprotic acid" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_IsDiproticAcid" buildMode="Property" visible="0" canBeVaried="0" />
-            <Parameter id="9CKaK7reVkeL00AkmJ-94w" name="Is diprotic base" description="Is diprotic base" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_IsDiproticBase" buildMode="Property" visible="0" canBeVaried="0" />
-            <Parameter id="RhSe1hCeDUe3FYJeAR6p5Q" name="Is diprotic base monoprotic acid" description="Is diprotic base monoprotic acid" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_IsDiproticBaseMonoproticAcid" buildMode="Property" visible="0" canBeVaried="0" />
-            <Parameter id="ZzzcYMnjGkO-u0ZvJ1c5CQ" name="Is floating in lumen" description="Is floating in lumen" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="0" canBeVaried="0" value="1" />
-            <Parameter id="SWMdA8LmxkqkEo6JAD0_BQ" name="Is monoprotic acid" description="Is monoprotic acid" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_IsMonoproticAcid" buildMode="Property" visible="0" canBeVaried="0" />
-            <Parameter id="yGs1ItV5xUS8qWLIvmL4yA" name="Is monoprotic base" description="Is monoprotic base" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_IsMonoproticBase" buildMode="Property" visible="0" canBeVaried="0" />
-            <Parameter id="ybNEVSGwUkmYITpmAT6ceQ" name="Is monoprotic base diprotic acid" description="Is monoprotic base diprotic acid" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_IsMonoproticBaseDiproticAcid" buildMode="Property" visible="0" canBeVaried="0" />
-            <Parameter id="5iUMJux-fU-0mwpK2EJYGQ" name="CT_NEUTRAL" description="Constant for compound type neutral" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="0" canBeVaried="0" value="0" />
-            <Parameter id="XHY79l31GEGJWLQwwynKOg" name="Lipophilicity" description="Model dependent lipophilicity measure: LogMA / LogP / ..." persistable="0" isFixedValue="0" dim="Log Units" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="1" value="3" displayUnit="Log Units" />
-            <Parameter id="qTs5l6MHuUWrPqhRbf3UXg" name="Fraction unbound (plasma, reference value)" description="Fraction unbound in plasma of the reference individual, i.e. in the case of human typically an average healthy adult. This reference value can be scaled to children based on the ontogeny of the respective plasma protein and/or in diseased subjects using the plasma protein scale factor defined in the individual" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="1" value="0.11" />
-            <Parameter id="uh2bp2PeyUWjhgox1CXiWw" name="Solubility at reference pH" description="Solubility at reference pH" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="1" value="1.2E-05" displayUnit="mg/l" />
-            <Parameter id="-gUBeFROlECO_mKXcNi9DA" name="Reference pH" description="Reference pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="1" value="7" />
-            <Parameter id="N8GV3kaNVEC36627mey0mA" name="Solubility gain per charge" description="Supporting parameter for calculation of pKa- and pH- dependent values of intestinal solubilty" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="0" value="1000" />
-            <Parameter id="WDu5ixtj2UmyMQ3giYzQug" name="Permeability" description="Permeability" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_P" buildMode="Property" visible="1" canBeVaried="1" displayUnit="cm/min" />
-            <Parameter id="7rLTdh8iakSRF64PWH7I5Q" name="Specific intestinal permeability (transcellular)" description="Specific intestinal permeability (transcellular)" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_InVitro" buildMode="Property" visible="1" canBeVaried="1" displayUnit="cm/min" />
-            <Parameter id="EbNmqMWvm0y2hWBaj1lVHA" name="Partition coefficient (water/protein)" description="Partition coefficient water to protein" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionInVitro_PKSim.PARAM_KProt" buildMode="Property" visible="1" canBeVaried="1" />
-            <Parameter id="efndwNgCLEm9Fb8oIvrfiQ" name="Treat precipitated drug as" description="Treat precipitated drug as either soluble or insoluble" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="1" value="1" />
-            <Parameter id="4gGzHYEtokq-ZG48qCm-iA" name="Aqueous diffusion coefficient" description="Aqueous diffusion coefficient&#xA;of the drug" persistable="0" isFixedValue="0" dim="Diffusion coefficient" quantityType="Parameter" formula="CompoundCommon.PARAM_Aqueous_diffusion_coefficient" buildMode="Property" visible="1" canBeVaried="1" displayUnit="cm²/min" />
-            <Parameter id="vDD9t_kiu0yeweRkrpA9ag" name="Density (drug)" description="Density of drug material" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="1" value="1" displayUnit="g/cm³" />
-            <Parameter id="wdI8I-pYV0KLhpAszsPVig" name="Immediately dissolve particles smaller than" description="Threshold for the particle radius of immediate dissolution" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="1" value="1E-07" displayUnit="µm" />
-            <Parameter id="IIWTulndYEW76LuQ512ZNA" name="Radius (solute)" description="Solute radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="CompoundCommon.PARAM_Ae" buildMode="Property" visible="1" canBeVaried="1" displayUnit="µm" />
-            <Parameter id="oXkyQIxAM0qHk6Q9m2HBQQ" name="Kd (FcRn) in endosomal space" description="Dissociation constant of drug for binding to FcRn in endosomal space" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="0" value="999999" displayUnit="µmol/l" />
-            <Parameter id="OskmEv7jE026Q7ams_Npbw" name="Kd (FcRn) in plasma/interstitial" description="Dissociation constant of drug for binding to FcRn in plasma/interstitial space. For monoclonal antibodies the binding to FcRn in neutral environment (plasma and interstitial space) is generally very weak or not detectable. In this case the high default value for Kd(FcRn) in plasma/interstitial can be kept." persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="0" value="999999" displayUnit="µmol/l" />
-            <Parameter id="3nG-WVwx8UaDRY8uVTLl8Q" name="kass (FcRn)" description="Association constant of drug for binding to FcRn" persistable="0" isFixedValue="0" dim="Second order rate constant" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="0" value="60" displayUnit="l/µmol/min" />
-            <Parameter id="XwNtnab1bUmCUc2hc9Sxkw" name="Use pH- and pKa-dependent penalty factor for charged molecule fraction" description="Penalty factor for charged molecule fraction is used for &quot;Intestinal permeability (transcellular)&quot; only" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="1" value="0" />
-            <Parameter id="WuoIu1euP0qT9-GMbTXH4g" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="ConcFormula" visible="0" canBeVaried="0" />
-          </Children>
-          <UsedCalculationMethods>
-            <UsedCalculationMethod category="DistributionCellular" calculationMethod="Cellular partition coefficient method - PK-Sim Standard" />
-            <UsedCalculationMethod category="DiffusionIntCell" calculationMethod="Cellular permeability - PK-Sim Standard" />
-            <UsedCalculationMethod category="DistributionInterstitial" calculationMethod="Interstitial partition coefficient method - Schmitt" />
-          </UsedCalculationMethods>
-        </MoleculeBuilder>
-      </Builders>
-      <FormulaCache>
-        <Formulas>
-          <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_TwoAcids_0" name="PARAM_pKa_TwoAcids_0" dim="Dimensionless" formula="pKa_Acids_Count=2 ? (CT0 != CT_ACID ? Min(pKa_1;pKa_2) : (CT1 != CT_ACID ? Min(pKa_0;pKa_2) : Min(pKa_0;pKa_1))) : 0">
-            <Paths>
-              <Path path="0" as="1" />
-              <Path path="2" as="3" />
-              <Path path="4" as="5" />
-              <Path path="6" as="7" />
-              <Path path="8" as="9" />
-              <Path path="10" as="11" />
-              <Path path="12" as="13" />
-            </Paths>
-          </Formula>
-          <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_K2" name="PARAM_pKa_pH_WS_sol_K2" dim="Dimensionless" formula="(1-F1)*F2*F3">
-            <Paths>
-              <Path path="14" as="15" />
-              <Path path="16" as="17" />
-              <Path path="18" as="19" />
-            </Paths>
-          </Formula>
-          <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_K3" name="PARAM_pKa_pH_WS_sol_K3" dim="Dimensionless" formula="F1*(1-F2)*F3">
-            <Paths>
-              <Path path="14" as="15" />
-              <Path path="16" as="17" />
-              <Path path="18" as="19" />
-            </Paths>
-          </Formula>
-          <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_K4" name="PARAM_pKa_pH_WS_sol_K4" dim="Dimensionless" formula="F1*F2*(1-F3)">
-            <Paths>
-              <Path path="14" as="15" />
-              <Path path="16" as="17" />
-              <Path path="18" as="19" />
-            </Paths>
-          </Formula>
-          <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_K5" name="PARAM_pKa_pH_WS_sol_K5" dim="Dimensionless" formula="(1-F1)*(1-F2)*F3">
-            <Paths>
-              <Path path="14" as="15" />
-              <Path path="16" as="17" />
-              <Path path="18" as="19" />
-            </Paths>
-          </Formula>
-          <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_K6" name="PARAM_pKa_pH_WS_sol_K6" dim="Dimensionless" formula="(1-F1)*F2*(1-F3)">
-            <Paths>
-              <Path path="14" as="15" />
-              <Path path="16" as="17" />
-              <Path path="18" as="19" />
-            </Paths>
-          </Formula>
-          <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_K7" name="PARAM_pKa_pH_WS_sol_K7" dim="Dimensionless" formula="F1*(1-F2)*(1-F3)">
-            <Paths>
-              <Path path="14" as="15" />
-              <Path path="16" as="17" />
-              <Path path="18" as="19" />
-            </Paths>
-          </Formula>
-          <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_K8" name="PARAM_pKa_pH_WS_sol_K8" dim="Dimensionless" formula="(1-F1)*(1-F2)*(1-F3)">
-            <Paths>
-              <Path path="14" as="15" />
-              <Path path="16" as="17" />
-              <Path path="18" as="19" />
-            </Paths>
-          </Formula>
-          <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_ThreeAcids_0" name="PARAM_pKa_ThreeAcids_0" dim="Dimensionless" formula="IsTriproticAcid ? Min (pKa_0; Min (pKa_1; pKa_2)) : 0">
-            <Paths>
-              <Path path="20" as="21" />
-              <Path path="6" as="7" />
-              <Path path="8" as="9" />
-              <Path path="10" as="11" />
-            </Paths>
-          </Formula>
-          <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_ThreeAcids_1" name="PARAM_pKa_ThreeAcids_1" dim="Dimensionless" formula="IsTriproticAcid ? (pKa_0 &lt;= pKa_Acid_0 ? min(pKa_1; pKa_2) : (pKa_0 &gt;= pKa_Acid_2 ? max(pKa_1; pKa_2) : pKa_0)) : 0">
-            <Paths>
-              <Path path="20" as="21" />
-              <Path path="6" as="7" />
-              <Path path="8" as="9" />
-              <Path path="10" as="11" />
-              <Path path="22" as="23" />
-              <Path path="24" as="25" />
-            </Paths>
-          </Formula>
-          <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_ThreeBases_1" name="PARAM_pKa_ThreeBases_1" dim="Dimensionless" formula="IsTriproticBase ? (pKa_0 &lt;= pKa_Base_0 ? min(pKa_1; pKa_2) : (pKa_0 &gt;= pKa_Base_2 ? max(pKa_1; pKa_2) : pKa_0)) : 0">
-            <Paths>
-              <Path path="26" as="27" />
-              <Path path="6" as="7" />
-              <Path path="8" as="9" />
-              <Path path="10" as="11" />
-              <Path path="28" as="29" />
-              <Path path="30" as="31" />
-            </Paths>
-          </Formula>
-          <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_TwoAcids_1" name="PARAM_pKa_TwoAcids_1" dim="Dimensionless" formula="pKa_Acids_Count=2 ? (CT0 != CT_ACID ? Max(pKa_1;pKa_2) : (CT1 != CT_ACID ? Max(pKa_0;pKa_2) : Max(pKa_0;pKa_1))) : 0">
-            <Paths>
-              <Path path="0" as="1" />
-              <Path path="2" as="3" />
-              <Path path="4" as="5" />
-              <Path path="6" as="7" />
-              <Path path="8" as="9" />
-              <Path path="10" as="11" />
-              <Path path="12" as="13" />
-            </Paths>
-          </Formula>
-          <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_TwoBases_0" name="PARAM_pKa_TwoBases_0" dim="Dimensionless" formula="pKa_Bases_Count=2 ? (CT0 != CT_BASE ? Min(pKa_1;pKa_2) : (CT1 != CT_BASE ? Min(pKa_0;pKa_2) : Min(pKa_0;pKa_1))) : 0">
-            <Paths>
-              <Path path="0" as="1" />
-              <Path path="2" as="3" />
-              <Path path="32" as="33" />
-              <Path path="6" as="7" />
-              <Path path="8" as="9" />
-              <Path path="10" as="11" />
-              <Path path="34" as="35" />
-            </Paths>
-          </Formula>
-          <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_TwoBases_1" name="PARAM_pKa_TwoBases_1" dim="Dimensionless" formula="pKa_Bases_Count=2 ? (CT0 != CT_BASE ? Max(pKa_1;pKa_2) : (CT1 != CT_BASE ? Max(pKa_0;pKa_2) : Max(pKa_0;pKa_1))) : 0">
-            <Paths>
-              <Path path="0" as="1" />
-              <Path path="2" as="3" />
-              <Path path="32" as="33" />
-              <Path path="6" as="7" />
-              <Path path="8" as="9" />
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-          </Formula>
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-            <Paths>
-              <Path path="0" as="1" />
-              <Path path="2" as="3" />
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-            <Paths>
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-              <Path path="36" as="62" />
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-          </Formula>
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-            <Paths>
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-              <Path path="6" as="7" />
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-            <Paths>
-              <Path path="0" as="1" />
-              <Path path="2" as="3" />
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-            <Paths>
-              <Path path="73" as="74" />
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-            </Paths>
-          </Formula>
-          <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_Base_2" name="PARAM_pKa_Base_2" dim="Dimensionless" formula="IsTriproticBase ? Max (pKa_0; Max (pKa_1; pKa_2)) : 0">
-            <Paths>
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-              <Path path="6" as="7" />
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-              <Path path="10" as="11" />
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-          </Formula>
-          <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_OneAcid_0" name="PARAM_pKa_OneAcid_0" dim="Dimensionless" formula="pKa_Acids_Count=1 ? (CT0=CT_ACID ? pKa_0 : (CT1=CT_ACID ? pKa_1 : pKa_2)) : 0">
-            <Paths>
-              <Path path="0" as="1" />
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-              <Path path="6" as="7" />
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-              <Path path="10" as="11" />
-              <Path path="12" as="13" />
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-          </Formula>
-          <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_OneBase_0" name="PARAM_pKa_OneBase_0" dim="Dimensionless" formula="pKa_Bases_Count=1 ? (CT0=CT_BASE ? pKa_0 : (CT1=CT_BASE ? pKa_1 : pKa_2)) : 0">
-            <Paths>
-              <Path path="0" as="1" />
-              <Path path="2" as="3" />
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-              <Path path="6" as="7" />
-              <Path path="8" as="9" />
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-            </Paths>
-          </Formula>
-          <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_F1" name="PARAM_pKa_pH_WS_sol_F1" dim="Dimensionless" formula="CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1">
-            <Paths>
-              <Path path="0" as="1" />
-              <Path path="79" as="80" />
-              <Path path="6" as="7" />
-              <Path path="81" as="82" />
-            </Paths>
-          </Formula>
-          <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_F2" name="PARAM_pKa_pH_WS_sol_F2" dim="Dimensionless" formula="CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1">
-            <Paths>
-              <Path path="2" as="3" />
-              <Path path="79" as="80" />
-              <Path path="8" as="9" />
-              <Path path="81" as="82" />
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-          </Formula>
-          <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_F3" name="PARAM_pKa_pH_WS_sol_F3" dim="Dimensionless" formula="CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1">
-            <Paths>
-              <Path path="36" as="37" />
-              <Path path="79" as="80" />
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-              <Path path="81" as="82" />
-            </Paths>
-          </Formula>
-          <Formula id="CompoundMW_PKSim.PARAM_MWEff" name="PARAM_MWEff" dim="Molecular weight" formula="MW - F * 0.000000017 - Cl * 0.000000022 - Br * 0.000000062 - I * 0.000000098">
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-          </Formula>
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-            </Paths>
-          </Formula>
-          <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_InVitro" name="PARAM_P_int_InVitro" dim="Velocity" formula="IsSmallMolecule ? 266 * (MWEff * 1E9) ^ ( - 4.5) * 10^LogMA * 60 *1E-1 : 0">
-            <Paths>
-              <Path path="94" as="95" dim="93" />
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-          </Formula>
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-            <Paths>
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-          <Formula id="CompoundAcidBase_PKSim.PARAM_IsDiproticBase" name="PARAM_IsDiproticBase" dim="Dimensionless" formula="pKa_Acids_Count=0 &amp; pKa_Bases_Count = 2 ? 1 : 0">
-            <Paths>
-              <Path path="12" as="13" />
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-            <Paths>
-              <Path path="12" as="13" />
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-            <Paths>
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-          <Formula id="CompoundAcidBase_PKSim.PARAM_IsMonoproticBase" name="PARAM_IsMonoproticBase" dim="Dimensionless" formula="pKa_Acids_Count=0 &amp; pKa_Bases_Count = 1 ? 1 : 0">
-            <Paths>
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-          <Formula id="CompoundAcidBase_PKSim.PARAM_IsMonoproticBaseDiproticAcid" name="PARAM_IsMonoproticBaseDiproticAcid" dim="Dimensionless" formula="pKa_Acids_Count=2 &amp; pKa_Bases_Count = 1 ? 1 : 0">
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-              <Path path="12" as="13" />
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-          <Formula id="DistributionInVitro_PKSim.PARAM_KProt" name="PARAM_KProt" dim="Dimensionless" formula="(0.81 + 0.11 * 10^LogMA) / 24.92 * 5.0">
-            <Paths>
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-          <Map s="..|Solubility gain per charge" id="54" />
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-          <Map s="..|Molecular weight" id="91" />
-          <Map s="MW" id="92" />
-          <Map s="Molecular weight" id="93" />
-          <Map s="..|Effective molecular weight" id="94" />
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-                    <Parameter id="gF5SfxxXXk-JXTlYpd1OYg" name="Tablet_Location_rect" description="Tablet location in Rectum" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="xNJ6alhDWkOaAF6tGcl7Mg" visible="0" canBeVaried="0" />
-                    <Parameter id="FGrbJ24ppk6cUKupGtLBIA" name="Tablet_Location_uil" description="Tablet location in Upper Ileum" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="wy4wljavtkGCx1UGk4mCKQ" visible="0" canBeVaried="0" />
-                    <Parameter id="tvaFeXMFDEqxj3qjv3ZHMA" name="Tablet_Location_lje" description="Tablet location in Lower Jejunum" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="r6Y9bVqtbU-VV3-5-90LYw" visible="0" canBeVaried="0" />
-                    <Parameter id="XnH75oRjKUqWJOMLUYx9dw" name="Tablet_Location_lil" description="Tablet location in Lower Ileum" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="U23wRhspxUC1d5dDSkbfvw" visible="0" canBeVaried="0" />
-                    <Parameter id="arrF5OJSJ0qg0kJWdVk1aQ" name="Tablet_Location_cae" description="Tablet location in Cecum" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BLVaeT1Z8EaDaGKBKDsQoQ" visible="0" canBeVaried="0" />
-                    <Parameter id="d3mK7gamDUWNJ_XbYzxD1w" name="Tablet_Location_coltrans" description="Tablet location in Colon Transversum" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="lRg5U54bSEK1ih_ezgdOTA" visible="0" canBeVaried="0" />
-                    <Parameter id="owCxv6B0lk6-4j81hQCuRg" name="Tablet_Location_colasc" description="Tablet location in Colon Ascendens" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="EjUbnPsYEk-XZ5hW3OYdaA" visible="0" canBeVaried="0" />
-                    <Parameter id="FifZEsq0yUGhxSqfhmYi8w" name="Tablet_Location_duo" description="Tablet location in Duodenum" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="bCbAL8iC3UGPA34KcbXg4Q" visible="0" canBeVaried="0" />
-                    <Parameter id="MXMTpuP3bUKYPD9eBYjx5Q" name="Tablet_Location_colsigm" description="Tablet location in Colon Sigmoid" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="3PD9tWoLY0q2v3ekNvhFpg" visible="0" canBeVaried="0" />
-                    <Parameter id="r0qbLnYFSUOk0TA-FHPgPw" name="Tablet_Location_coldesc" description="Tablet location in Colon Descendens" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="nYVUeXChU0ermVWFPiKMxA" visible="0" canBeVaried="0" />
-                    <Parameter id="G6mo3ZfFDUaAXuGuFtyFNQ" name="Tablet_Location" description="Tablet location in lumen" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="0" rHSFormula="UDkPHOp750Sk2Kd-KH7f8w" value="1.99" />
-                    <Parameter id="wDc3lrfwX0CKhHQhuvO4_g" name="TabletIsActive" description="Enables/disables all tablet interactions" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="0" value="0" />
-                    <Parameter id="EFsnU9lptUWyCrfw-fKFVg" name="Tablet_Location_uje" description="Tablet location in Upper Jejunum" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="cfyjeV6_fUGZWtxkliWtTA" visible="0" canBeVaried="0" />
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-                      <Tags>
-                        <Tag value="Application" />
-                        <Tag value="Application_1" />
-                      </Tags>
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-                          <ObjectPath path="0" />
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-                          <ObjectPath path="2" />
-                        </EventAssignmentBuilder>
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-                          <ObjectPath path="3" />
-                        </EventAssignmentBuilder>
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-                    </EventBuilder>
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-                      <Tags>
-                        <Tag value="Application" />
-                        <Tag value="Application_1" />
-                      </Tags>
-                      <Assignments>
-                        <EventAssignmentBuilder id="28IK4Hek5Uu6DaNNBdmaKg" name="Assignment_1" useAsValue="0" dimension="Dimensionless" formula="7LLMfNQaKUmS_HAsJxjMMQ">
-                          <ObjectPath path="1" />
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-                      <Tags>
-                        <Tag value="Application" />
-                        <Tag value="Application_1" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="1zj11D6VAkaIYgT3Jfa81w" name="Start time" description="Start time of application" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" visible="1" canBeVaried="1" value="0" displayUnit="h" />
-                        <Parameter id="-ArJHGTM7Umk1ebXHx0KtA" name="DosePerBodyWeight" description="Dose" persistable="0" isFixedValue="0" dim="Dose per body weight" quantityType="Parameter" visible="1" canBeVaried="1" value="1E-06" displayUnit="mg/kg" />
-                        <Parameter id="EYP8swob7U2U1IAzWSm8fg" name="DrugMass" description="Drug mass of application" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" formula="aFEcqAV6nEOfzVOTRfs8Bg" visible="0" canBeVaried="1" displayUnit="µmol" />
-                        <Parameter id="1QX0EgEXxkeFXTGflf960Q" name="Dose" description="Dose" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="7KxL5YlgvEGOd6HUnFJcFQ" visible="0" canBeVaried="1" displayUnit="mg" />
-                        <Parameter id="MrF25lZfo0qFyb78fakq1w" name="Volume of water/body weight" description="Volume of water per body weight co-administered with the drug" persistable="0" isFixedValue="0" dim="Volume per body weight" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0035" displayUnit="ml/kg" />
-                        <Parameter id="RcZAwmuKJESLYPLorhsg9Q" name="Amount of water" description="Amount of water" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="1D2srxV-OkKtZ_efyJA8IQ" visible="0" canBeVaried="1" displayUnit="l" />
-                      </Children>
-                    </Container>
-                    <EventGroupBuilder id="5UczG7RfFU6cWZgvCtbs3A" name="ParticleBin_1" description="Particle Bin #1" mode="Logical" containerType="Other">
-                      <Tags>
-                        <Tag value="ParticleBin" />
-                        <Tag value="Application" />
-                        <Tag value="Application_1" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="q8Qu5W_pg0iewChVzx8cdQ" name="Number_Of_Particles_Factor" description="Factor for number of particles (depends on particle radius distribution)" persistable="0" isFixedValue="0" dim="Inversed volume" quantityType="Parameter" visible="0" canBeVaried="0" value="238732414637.843" displayUnit="1/l" />
-                        <Parameter id="ScSn42Nm4U-Wufks-uybFA" name="Fraction solid" description="Fraction of solid drug" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" formula="M5_jw_5KB0qF48k1do3h1A" visible="0" canBeVaried="0" />
-                        <Parameter id="m4-vbW5lekS4V3uF_RvSlw" name="Fraction insoluble" description="Fraction of insoluble drug" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" formula="31EEJmL9nEmYF1u6PZxc0A" visible="0" canBeVaried="0" />
-                        <Parameter id="3PL38V3qfkC4IRxStMxoUw" name="Fraction dissolved" description="Fraction of dissolved drug" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" formula="2E8zGNlz7Uyby46M64j4kA" visible="0" canBeVaried="0" />
-                        <Parameter id="1QqZovxzqUWn8znMzgUQtw" name="DrugMass of particle bin" description="Drug mass of a single particle bin" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" formula="BCIc-hCmZ06uWmDcv9Nquw" visible="0" canBeVaried="1" displayUnit="µmol" />
-                        <Parameter id="9icT8WvDaU-CJ3lek5xtYQ" name="Number of particles" description="Number of drug particles in one particle bin" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="MQDEl9Z6rUSXE_c6Fv7aIQ" visible="1" canBeVaried="1" />
-                        <Parameter id="Z3qolRb0D0m5B8zXJZg_nw" name="Particle radius (at t=0)" description="Particle radius at t=0" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0001" displayUnit="µm" />
-                        <Parameter id="2Tv3rBCUgU2VQMUsqbFV3A" name="Particle radius" description="Particle radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="0" value="0" displayUnit="µm" />
-                        <EventBuilder id="dRV2BiIvBkGdoNbctKUBUw" name="ParticleBinDissolvedEvent" description="ParticleBinDissolvedEvent" oneTime="1" dimension="Dimensionless" formula="GdKAJyDASkKWTPihiEU0oQ">
-                          <Tags>
-                            <Tag value="Application" />
-                            <Tag value="Application_1" />
-                          </Tags>
-                          <Assignments>
-                            <EventAssignmentBuilder id="N-E70yTV00yGTWqIxJmQLw" name="Assignment_1" useAsValue="1" dimension="Amount" formula="EUaozAs_m0ui-y2MFQsaVw">
-                              <ObjectPath path="4" />
-                            </EventAssignmentBuilder>
-                            <EventAssignmentBuilder id="NIo1254YO06f5oUY8UEniQ" name="Assignment_2" useAsValue="1" dimension="Amount" formula="ZSu58Oc01U6I7Meb8Cb4FQ">
-                              <ObjectPath path="5" />
-                            </EventAssignmentBuilder>
-                            <EventAssignmentBuilder id="YfZrgoB670u9kvHH1FMeaQ" name="Assignment_3" useAsValue="1" dimension="Amount" formula="R6B38acty0uAYSIr6_HIJw">
-                              <ObjectPath path="6" />
-                            </EventAssignmentBuilder>
-                            <EventAssignmentBuilder id="6cqvPTjUkUm4DbUWZOM_3w" name="Assignment_4" useAsValue="1" dimension="Amount" formula="1AhQ0ZzxIUq6X8PEtQ85nw">
-                              <ObjectPath path="7" />
-                            </EventAssignmentBuilder>
-                            <EventAssignmentBuilder id="ae3VcXTNkk2WYZHWFlc0aQ" name="Assignment_5" useAsValue="1" dimension="Amount" formula="WjzeKBKFwkSBW5rK2QpwFQ">
-                              <ObjectPath path="8" />
-                            </EventAssignmentBuilder>
-                            <EventAssignmentBuilder id="FioDrGTfvUiFe9dAOK-UUA" name="Assignment_6" useAsValue="1" dimension="Amount" formula="Oeh_GVG62U2ZYSSDFfbY-g">
-                              <ObjectPath path="9" />
-                            </EventAssignmentBuilder>
-                            <EventAssignmentBuilder id="dEzKylUumEOnCawddhqaTg" name="Assignment_7" useAsValue="1" dimension="Amount" formula="Pw60ZsJrykOpNjTeatVnow">
-                              <ObjectPath path="10" />
-                            </EventAssignmentBuilder>
-                            <EventAssignmentBuilder id="MnLnWDZGjEmQ5lhzGOFxbw" name="Assignment_8" useAsValue="1" dimension="Amount" formula="qTLW4OYT2EG14ie4wPMjqA">
-                              <ObjectPath path="11" />
-                            </EventAssignmentBuilder>
-                            <EventAssignmentBuilder id="iv5_shKsSkGltZbZYmBaNg" name="Assignment_9" useAsValue="1" dimension="Amount" formula="quKLC_EehUuzNgEj3P0qQw">
-                              <ObjectPath path="12" />
-                            </EventAssignmentBuilder>
-                            <EventAssignmentBuilder id="Ya-fPwV2sEuI4vH_TJsuNg" name="Assignment_10" useAsValue="1" dimension="Amount" formula="6otjFd3ua0OA6G16oImT3w">
-                              <ObjectPath path="13" />
-                            </EventAssignmentBuilder>
-                            <EventAssignmentBuilder id="n9sxbG9U1kypji6dBJaeyg" name="Assignment_11" useAsValue="1" dimension="Amount" formula="GceZW05IbEq4aiNwrfSk8g">
-                              <ObjectPath path="14" />
-                            </EventAssignmentBuilder>
-                            <EventAssignmentBuilder id="eGWIpzI53UyUWtl7DRJHVw" name="Assignment_12" useAsValue="1" dimension="Amount" formula="OwNWwgPhrE2ZPeK6lpxG5g">
-                              <ObjectPath path="15" />
-                            </EventAssignmentBuilder>
-                            <EventAssignmentBuilder id="bLh0vDZLZ06OGaeSAK7vgQ" name="Assignment_13" useAsValue="1" dimension="Dimensionless" formula="H0rjUJgqK0C1XzL8J-rRIA">
-                              <ObjectPath path="16" />
-                            </EventAssignmentBuilder>
-                          </Assignments>
-                        </EventBuilder>
-                        <Container id="J4-06znfDkKWKajCkzNVnw" name="InsolubleDrug" description="Insoluble Drug during particle dissolution" mode="Logical" containerType="Other">
-                          <Tags>
-                            <Tag value="InsolubleDrug" />
-                            <Tag value="Application" />
-                            <Tag value="Application_1" />
-                          </Tags>
-                        </Container>
-                      </Children>
-                      <SourceCriteria />
-                    </EventGroupBuilder>
-                    <ApplicationMoleculeBuilder id="zZX7EmJ8L0K4vHoUiTyt6A" name="ParticleBin_1_soluble" formula="aZozMwF_Rkmet40DUcX4DQ">
-                      <RelativeContainerPath path="17" />
-                    </ApplicationMoleculeBuilder>
-                    <ApplicationMoleculeBuilder id="9H30f4hd5kC1SbHinALF_Q" name="ParticleBin_1_insoluble" formula="FSz8UlUWT0OYY1cQSyBiJg">
-                      <RelativeContainerPath path="18" />
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-                    <DescriptorConditions>
-                      <MatchTagCondition tag="Applications" />
-                    </DescriptorConditions>
-                  </SourceCriteria>
-                </ApplicationBuilder>
-              </Children>
-              <SourceCriteria />
-            </EventGroupBuilder>
-            <Parameter id="1_w4axjKIkG0hha6UXvw0g" name="TotalDrugMass" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" formula="uZqeiRhVakCqrb7NOKYxEw" visible="0" canBeVaried="0" displayUnit="µmol" />
-          </Children>
-          <SourceCriteria>
-            <DescriptorConditions>
-              <MatchTagCondition tag="RootContainer" />
-            </DescriptorConditions>
-          </SourceCriteria>
-        </EventGroupBuilder>
-        <EventGroupBuilder id="Jx5-8QxkS0qk6Qt60lFg8Q" name="Fressen" mode="Logical" containerType="Other">
-          <Children>
-            <Parameter id="N7TFSJj9MkeL07brnK4Z-Q" name="Meal_pH_exponent" description="Meal_pH_exponent" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-            <Parameter id="NtQ5D4rrY06P_WOQpC3MMw" name="Meal energy content" description="Energy content of the meal administered" persistable="0" isFixedValue="0" dim="Energy" quantityType="Parameter" visible="1" canBeVaried="1" value="1506240000000" displayUnit="kcal" />
-            <Parameter id="-vRjVK4l_UaxmVqQR4eEsg" name="GET_alpha (Weibull function)" description="Supporting parameter for gastric emptying rate" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="E7UDdg62nESh-_ZRsj7J_Q" visible="0" canBeVaried="1" />
-            <Parameter id="_LSJHSYH-UOklj0c-XcINQ" name="GET_beta (Weibull function)" description="Supporting parameter for gastric emptying rate" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="tmjTClQJy0erOBkWEXuLGA" visible="0" canBeVaried="1" />
-            <Parameter id="EFm-VNcfe0imkR4qF0b2ww" name="Meal volume" description="Approximate volume of the meal administered" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="1" canBeVaried="1" value="0.592" displayUnit="l" />
-            <Parameter id="M-HZTylPx0q4qIc1395xBg" name="Meal fraction solid" description="Fraction of solid components of the meal administered" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" visible="1" canBeVaried="1" value="0.6" />
-            <Parameter id="Ej4vYFgz60iQNNZQ_n3gQA" name="Gallbladder emptying enabled" description="Enable gallbladder emptying. &#xD;&#xA;This will activate discrete mass flow from the gallbladder into the duodenum. &#xD;&#xA;&#xD;&#xA;In order to activate continuous mass flow from the liver into the duodenum &#xD;&#xA;please change the EHC continuous fraction in the Building Block Individual accordingly.&#xD;&#xA;&#xD;&#xA;Please note that enabling gallbladder emptying &#xD;&#xA;does not automatically imply active secretion of the compound into the bile!&#xD;&#xA;&#xD;&#xA;In order to enable active secretion into the bile please &#xD;&#xA;either implement a transport process of the type efflux or P-gp like efflux &#xD;&#xA;at the apical side of the liver &#xD;&#xA;or introduce a biliary clearance process in the Compound Building Block." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="1" />
-            <Parameter id="19T0nBGfGE6KEEfW5cGhrw" name="Gallbladder emptying lag time" description="Lag time between administration of the meal and gallbladder emptying" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" visible="1" canBeVaried="1" value="30" displayUnit="min" />
-            <EventGroupBuilder id="IikJjZxX0EiYZgM4f9sBRQ" name="Fressen_1" mode="Logical" containerType="Other">
-              <Children>
-                <EventBuilder id="VdwMXhuA9UGxsiSTP-YoWw" name="Meal_StartEvent" description="Meal_StartEvent" oneTime="1" dimension="Dimensionless" formula="dEcmCPlxQk6xzCUrsGrkLA">
-                  <Assignments>
-                    <EventAssignmentBuilder id="z3au1tebE0GROKKWhmTxeA" name="Assignment_1" useAsValue="1" dimension="Volume" formula="on_ehXPjtUu3B67V6iN_jw">
-                      <ObjectPath path="3" />
-                    </EventAssignmentBuilder>
-                    <EventAssignmentBuilder id="FVfhE8s8xkmMYjS9MYGckA" name="Assignment_2" useAsValue="0" dimension="Inversed time" formula="jcfVObYxRkqnq8eeCu3cEQ">
-                      <ObjectPath path="19" />
-                    </EventAssignmentBuilder>
-                    <EventAssignmentBuilder id="XeNw0s1BJkqh7lR5c5oi3w" name="Assignment_3" useAsValue="0" dimension="Dimensionless" formula="KyGW15Nj5UGJlgSzH0AObw">
-                      <ObjectPath path="20" />
-                    </EventAssignmentBuilder>
-                  </Assignments>
-                </EventBuilder>
-                <EventBuilder id="RN1Ns82SzEeIsaFZRJ3NlA" name="Meal_StopEvent" description="Meal_StopEvent" oneTime="1" dimension="Dimensionless" formula="QF4KXv07mkSTYhezZW0Ydg">
-                  <Assignments>
-                    <EventAssignmentBuilder id="je8RHMwk_0i4j9qMCSNotQ" name="Assignment_1" useAsValue="0" dimension="Inversed time" formula="R6vanvXe80uB9anndOCk1Q">
-                      <ObjectPath path="19" />
-                    </EventAssignmentBuilder>
-                  </Assignments>
-                </EventBuilder>
-                <EventBuilder id="-frqkMi3SUyrvmXTw5PWWg" name="EHC_Start_Event" description="Start of (exponential) Emptying Gallbladder -&gt; Lumen/Duodenum" oneTime="1" dimension="Dimensionless" formula="3G0ylJtpj0SoHv2RiJpHCQ">
-                  <Assignments>
-                    <EventAssignmentBuilder id="eJYs6VUK0EeI_-VvIZq9Gg" name="Assignment_1" useAsValue="1" dimension="Dimensionless" formula="Db21IERYhkWSQgCoxzUBbw">
-                      <ObjectPath path="2" />
-                    </EventAssignmentBuilder>
-                    <EventAssignmentBuilder id="y_tkpPwCGky8GhJL-7RI4A" name="Assignment_2" useAsValue="0" dimension="Amount per time" formula="t8jFIpJaFky00sWLpe-2sw">
-                      <ObjectPath path="21" />
-                    </EventAssignmentBuilder>
-                  </Assignments>
-                </EventBuilder>
-                <EventBuilder id="W9rNTno8wkieJ4u1loCEAQ" name="EHC_Stop_Event" description="Stop of (exponential) Emptying Gallbladder -&gt; Lumen/Duodenum" oneTime="1" dimension="Dimensionless" formula="cQUqKgTI1kyjKql-yJRtng">
-                  <Assignments>
-                    <EventAssignmentBuilder id="BRgJRIJHcU20zRrXmtL4uw" name="Assignment_1" useAsValue="1" dimension="Time" formula="HxEjDxGCPUKdRhZI8bFy2w">
-                      <ObjectPath path="21" />
-                    </EventAssignmentBuilder>
-                  </Assignments>
-                </EventBuilder>
-                <Parameter id="3pBtGfGe-U2A6UfbkH1Zjw" name="Start time" description="Start time of application" persistable="0" isFixedValue="1" dim="Time" quantityType="Parameter" formula="l3ZbY2rVpUeE5e-XFw6K9Q" visible="1" canBeVaried="1" value="120" displayUnit="h" />
-              </Children>
-              <SourceCriteria>
-                <DescriptorConditions>
-                  <MatchTagCondition tag="Events" />
-                </DescriptorConditions>
-              </SourceCriteria>
-            </EventGroupBuilder>
-          </Children>
-          <SourceCriteria>
-            <DescriptorConditions>
-              <MatchTagCondition tag="Events" />
-            </DescriptorConditions>
-          </SourceCriteria>
-        </EventGroupBuilder>
-        <EventGroupBuilder id="VlWolxnbBEiCuywK4pDriA" name="EHC" mode="Logical" containerType="Other">
-          <Children>
-            <Parameter id="JCJvECVzzk675j3TjKzQHQ" name="Gallbladder emptying enabled" description="Enable gallbladder emptying. &#xD;&#xA;This will activate discrete mass flow from the gallbladder into the duodenum. &#xD;&#xA;&#xD;&#xA;In order to activate continuous mass flow from the liver into the duodenum &#xD;&#xA;please change the EHC continuous fraction in the Building Block Individual accordingly.&#xD;&#xA;&#xD;&#xA;Please note that enabling gallbladder emptying &#xD;&#xA;does not automatically imply active secretion of the compound into the bile!&#xD;&#xA;&#xD;&#xA;In order to enable active secretion into the bile please &#xD;&#xA;either implement a transport process of the type efflux or P-gp like efflux &#xD;&#xA;at the apical side of the liver &#xD;&#xA;or introduce a biliary clearance process in the Compound Building Block." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="1" />
-            <EventGroupBuilder id="lO26q6iVUEa82wYReMQ8Hw" name="EHC_1" mode="Logical" containerType="Other">
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-                <DescriptorConditions>
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-            <Paths>
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-            <Paths>
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-            <Paths>
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-          <Formula id="fXgl_sik2ke_Svb01wqgyA" name="MassTransferMucosaToPveBC" dim="Amount per time" formula="MassTransferMucosaToPveBCRate">
-            <Paths>
-              <Path path="32" as="33" dim="2" />
-            </Paths>
-          </Formula>
-          <Formula id="DVYK3hJ0IEq2y1n9eV7i_A" name="MassTransferMucosaToPvePlasma" dim="Amount per time" formula="MassTransferMucosaToPvePlasmaRate">
-            <Paths>
-              <Path path="34" as="35" dim="2" />
-            </Paths>
-          </Formula>
-          <Formula id="B12nxx_xskuqYtntHzYH7g" name="MassTransferOrgPl2BloodPool" dim="Amount per time" formula="Q*(1-HCT)*C_pls">
-            <Paths>
-              <Path path="23" as="16" dim="17" />
-              <Path path="18" as="19" dim="20" />
-              <Path path="21" as="22" />
-            </Paths>
-          </Formula>
-          <Formula id="IdbLmrUkGkW1PLSYzl98vg" name="MassTransferOrgPl2BloodPool_Liv" dim="Amount per time" formula="(Q_liv +Q_pve)*(1-HCT)*C_pls">
-            <Paths>
-              <Path path="23" as="36" dim="17" />
-              <Path path="18" as="19" dim="20" />
-              <Path path="37" as="38" dim="17" />
-              <Path path="21" as="22" />
-            </Paths>
-          </Formula>
-          <Formula id="ycdJ92Jf_k29xI3zFYc6ww" name="MassTransferOrgPl2BloodPool_Lng" dim="Amount per time" formula="Q*(1-HCT)*C_pls">
-            <Paths>
-              <Path path="23" as="16" dim="17" />
-              <Path path="18" as="19" dim="20" />
-              <Path path="21" as="22" />
-            </Paths>
-          </Formula>
-          <Formula id="9cWSaPTWNUOD3rhLSqUB7g" name="MassTransferOrgPl2BloodPool_pve" dim="Amount per time" formula="Q*(1-HCT)*C_pls">
-            <Paths>
-              <Path path="23" as="16" dim="17" />
-              <Path path="18" as="19" dim="20" />
-              <Path path="21" as="22" />
-            </Paths>
-          </Formula>
-          <Formula id="ytdrIuKYeEupu-qTrnasVQ" name="MassTransferOrgRBC2BloodPool" dim="Amount per time" formula="Q*HCT*C_bc">
-            <Paths>
-              <Path path="23" as="16" dim="17" />
-              <Path path="18" as="24" dim="20" />
-              <Path path="21" as="22" />
-            </Paths>
-          </Formula>
-          <Formula id="Y0hMTA2tw0yNQrQsw8KGRw" name="MassTransferOrgRBC2BloodPool_Liv" dim="Amount per time" formula="(Q_liv +Q_pve)*HCT*C_bc">
-            <Paths>
-              <Path path="23" as="36" dim="17" />
-              <Path path="18" as="24" dim="20" />
-              <Path path="37" as="38" dim="17" />
-              <Path path="21" as="22" />
-            </Paths>
-          </Formula>
-          <Formula id="GzSZ3WDiA0WYizM6T5ZQ0w" name="MassTransferOrgRBC2BloodPool_Lng" dim="Amount per time" formula="Q*HCT*C_bc">
-            <Paths>
-              <Path path="23" as="16" dim="17" />
-              <Path path="18" as="24" dim="20" />
-              <Path path="21" as="22" />
-            </Paths>
-          </Formula>
-          <Formula id="mimJ1AKSs0mZ2QFvjy5daw" name="MassTransferOrgRBC2BloodPool_Pve" dim="Amount per time" formula="Q*HCT*C_bc">
-            <Paths>
-              <Path path="23" as="16" dim="17" />
-              <Path path="18" as="24" dim="20" />
-              <Path path="21" as="22" />
-            </Paths>
-          </Formula>
-          <Formula id="Cm5W6mWKqUymGucwkhlt8w" name="PassiveDiffusionInt2Cell" dim="Amount per time" formula="K_water_int * PA_int_cell * C_int - K_water_cell * PA_cell_int * C_cell">
-            <Paths>
-              <Path path="39" as="40" dim="20" />
-              <Path path="18" as="41" dim="20" />
-              <Path path="42" as="43" dim="17" />
-              <Path path="44" as="45" dim="17" />
-              <Path path="46" as="47" />
-              <Path path="48" as="49" />
-            </Paths>
-          </Formula>
-          <Formula id="QFfOl6XROEetfUjZI9aRBg" name="PassiveDiffusionPl2Int" dim="Amount per time" formula="fu * P_endothelial * SA * (C_pls - C_int / K_int_pls)">
-            <Paths>
-              <Path path="39" as="41" dim="20" />
-              <Path path="18" as="19" dim="20" />
-              <Path path="50" as="51" dim="52" />
-              <Path path="53" as="54" dim="55" />
-              <Path path="56" as="57" />
-              <Path path="58" as="59" dim="60" />
-            </Paths>
-          </Formula>
-          <Formula id="KP_cf6Shi0-90K0il8fqaA" name="PassiveDiffusionPl2RBC" dim="Amount per time" formula="SA_bc * fu * (P_pls_rbc * C_pls - P_rbc_pls * C_bc  /K_rbc)">
-            <Paths>
-              <Path path="39" as="24" dim="20" />
-              <Path path="18" as="19" dim="20" />
-              <Path path="50" as="51" dim="52" />
-              <Path path="61" as="62" dim="55" />
-              <Path path="63" as="64" dim="55" />
-              <Path path="65" as="66" />
-              <Path path="67" as="68" dim="60" />
-            </Paths>
-          </Formula>
-          <Formula id="b8gO7rmzo0el0ZRTzcP8Ug" name="PassiveDiffusionPlsToSaliva" dim="Amount per time" formula="fu * (C_pls_art - C_slv / K_slv_pls) * Q_slv">
-            <Paths>
-              <Path path="69" as="70" dim="17" />
-              <Path path="71" as="72" dim="20" />
-              <Path path="39" as="73" dim="20" />
-              <Path path="50" as="51" dim="52" />
-              <Path path="74" as="75" />
-            </Paths>
-          </Formula>
-          <Formula id="oI9O5u8vekG4w47xoMfomA" name="GallbladderEmptyingRate" dim="Amount per time" formula="GallbladderEmptyingRate">
-            <Paths>
-              <Path path="76" as="77" dim="2" />
-            </Paths>
-          </Formula>
-        </Formulas>
-        <StringMap>
-          <Map s="NEIGHBORHOOD|MOLECULE|Drug absorption rate (lumen to mucosa)" id="0" />
-          <Map s="DrugAbsorptionLumenToMucosaRate" id="1" />
-          <Map s="Amount per time" id="2" />
-          <Map s="SOURCE|..|OralApplicationsEnabled" id="3" />
-          <Map s="OralApplicationsEnabled" id="4" />
-          <Map s="SOURCE|MOLECULE" id="5" />
-          <Map s="Drug" id="6" />
-          <Map s="Amount" id="7" />
-          <Map s="MOLECULE|Is floating in lumen" id="8" />
-          <Map s="IsFloatingInLumen" id="9" />
-          <Map s="SOURCE|Intestinal transit rate (absolute)" id="10" />
-          <Map s="w" id="11" />
-          <Map s="Inversed time" id="12" />
-          <Map s="TARGET|FillLevelFlag" id="13" />
-          <Map s="FillLevelFlagNext" id="14" />
-          <Map s="TARGET|..|Blood flow rate" id="15" />
-          <Map s="Q" id="16" />
-          <Map s="Flow" id="17" />
-          <Map s="SOURCE|MOLECULE|Concentration" id="18" />
-          <Map s="C_pls" id="19" />
-          <Map s="Concentration (molar)" id="20" />
-          <Map s="Organism|Hematocrit" id="21" />
-          <Map s="HCT" id="22" />
-          <Map s="SOURCE|..|Blood flow rate" id="23" />
-          <Map s="C_bc" id="24" />
-          <Map s="SOURCE|..|Mucosa blood flow fraction" id="25" />
-          <Map s="fractQ" id="26" />
-          <Map s="C" id="27" />
-          <Map s="NEIGHBORHOOD|MOLECULE|Mass transfer rate (intestine to mucosa blood cells)" id="28" />
-          <Map s="MassTransferIntestineToMucosaBCRate" id="29" />
-          <Map s="NEIGHBORHOOD|MOLECULE|Mass transfer rate (intestine to mucosa plasma)" id="30" />
-          <Map s="MassTransferIntestineToMucosaPlasmaRate" id="31" />
-          <Map s="NEIGHBORHOOD|MOLECULE|Mass transfer rate (mucosa to portal vein blood cells)" id="32" />
-          <Map s="MassTransferMucosaToPveBCRate" id="33" />
-          <Map s="NEIGHBORHOOD|MOLECULE|Mass transfer rate (mucosa to portal vein plasma)" id="34" />
-          <Map s="MassTransferMucosaToPvePlasmaRate" id="35" />
-          <Map s="Q_liv" id="36" />
-          <Map s="SOURCE|..|..|PortalVein|Blood flow rate" id="37" />
-          <Map s="Q_pve" id="38" />
-          <Map s="TARGET|MOLECULE|Concentration" id="39" />
-          <Map s="C_cell" id="40" />
-          <Map s="C_int" id="41" />
-          <Map s="NEIGHBORHOOD|MOLECULE|P*SA interstitial -&gt; intracellular" id="42" />
-          <Map s="PA_int_cell" id="43" />
-          <Map s="NEIGHBORHOOD|MOLECULE|P*SA intracellular -&gt; interstitial" id="44" />
-          <Map s="PA_cell_int" id="45" />
-          <Map s="NEIGHBORHOOD|MOLECULE|Partition coefficient (interstitial/water)" id="46" />
-          <Map s="K_water_int" id="47" />
-          <Map s="NEIGHBORHOOD|MOLECULE|Partition coefficient (intracellular/water)" id="48" />
-          <Map s="K_water_cell" id="49" />
-          <Map s="MOLECULE|Fraction unbound (plasma)" id="50" />
-          <Map s="fu" id="51" />
-          <Map s="Fraction" id="52" />
-          <Map s="NEIGHBORHOOD|MOLECULE|P (plasma&lt;-&gt;interstitial)" id="53" />
-          <Map s="P_endothelial" id="54" />
-          <Map s="Velocity" id="55" />
-          <Map s="NEIGHBORHOOD|MOLECULE|Partition coefficient (interstitial/plasma)" id="56" />
-          <Map s="K_int_pls" id="57" />
-          <Map s="NEIGHBORHOOD|Surface area (plasma/interstitial)" id="58" />
-          <Map s="SA" id="59" />
-          <Map s="Area" id="60" />
-          <Map s="MOLECULE|P (blood cells-&gt;plasma)" id="61" />
-          <Map s="P_rbc_pls" id="62" />
-          <Map s="MOLECULE|P (plasma-&gt;blood cells)" id="63" />
-          <Map s="P_pls_rbc" id="64" />
-          <Map s="MOLECULE|Partition coefficient (blood cells/plasma)" id="65" />
-          <Map s="K_rbc" id="66" />
-          <Map s="NEIGHBORHOOD|Surface area (blood cells/plasma)" id="67" />
-          <Map s="SA_bc" id="68" />
-          <Map s="SOURCE|..|Saliva flow rate" id="69" />
-          <Map s="Q_slv" id="70" />
-          <Map s="SOURCE|..|..|ArterialBlood|Plasma|MOLECULE|Concentration" id="71" />
-          <Map s="C_pls_art" id="72" />
-          <Map s="C_slv" id="73" />
-          <Map s="NEIGHBORHOOD|MOLECULE|Partition coefficient (intracellular/plasma)" id="74" />
-          <Map s="K_slv_pls" id="75" />
-          <Map s="Organism|Gallbladder|Gallbladder emptying rate" id="76" />
-          <Map s="GallbladderEmptyingRate" id="77" />
-        </StringMap>
-      </FormulaCache>
-    </PassiveTransports>
-    <Reactions id="esHKiSmAj0Cg7Dw7gEeA2Q" name="S1" bbVersion="0">
-      <FormulaCache>
-        <StringMap />
-      </FormulaCache>
-    </Reactions>
-    <SpatialStructure id="wBIJq8d_VUWC72nO3opZig" name="S1" bbVersion="0">
-      <GlobalMoleculeDependentProperties id="aCDZeL-HmU-PIo39dN7UMg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-        <Children>
-          <Parameter id="W5A89U7fAkeECwqJHUIxNA" name="P_bc_pls_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" buildMode="Global" visible="0" canBeVaried="1" />
-          <Parameter id="iWQ2vB4HL0WSj6O6ivMe0g" name="Intestinal permeability (paracellular)" description="Intestinal permeability via paracellular route" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" buildMode="Global" visible="1" canBeVaried="1" value="0" displayUnit="cm/min" />
-          <Parameter id="4Ne4PFjY90mSt3h5E9k8sg" name="Intestinal permeability (transcellular)" description="Intestinal permeability via transcellular route" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="IntestinalPermeability_PKSim.PARAM_P_int" buildMode="Global" visible="1" canBeVaried="1" displayUnit="cm/min" />
-          <Parameter id="jT_zQpK37EKus2E7fYAusw" name="Mucosa permeability scale factor (transcellular)" description="Used for scaling mucosa permeability with intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_MucosaPermeabilityScaleFactor_trans" buildMode="Global" visible="0" canBeVaried="0" />
-          <Parameter id="4rlNT-8LXU6c4_n8NPVDjw" name="P (plasma-&gt;blood cells)" description="Permeability from plasma to blood cells" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_P_pls_rbc" buildMode="Global" visible="1" canBeVaried="1" displayUnit="cm/min" />
-          <Parameter id="EskQOs4Mhk2oBlyru23GlQ" name="Default Intestinal permeability (transcellular)" description="Default Intestinal permeability via transcellular route" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="IntestinalPermeability_PKSim.PARAM_P_int_default" buildMode="Global" visible="0" canBeVaried="0" displayUnit="cm/min" />
-          <Parameter id="QgC0ENq2TkSPtoLf38lHsw" name="P_pls_bc_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" buildMode="Global" visible="0" canBeVaried="1" />
-          <Parameter id="7bPGA0780kWMpluZUaWTPg" name="Partition coefficient (blood cells/plasma)" description="Partition coefficient between blood cells and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" buildMode="Global" visible="1" canBeVaried="1" />
-          <Parameter id="PZjhJvpecUi3Amw9U0f0Uw" name="P (blood cells-&gt;plasma)" description="Permeability from blood cells to plasma" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_P_rbc_pls" buildMode="Global" visible="1" canBeVaried="1" displayUnit="cm/min" />
-          <Parameter id="_h1I3WvyJUGHtsEf7FfL6w" name="Fraction unbound (plasma)" description="Fraction unbound in plasma" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" formula="DistributionInVitro_PKSim.PARAM_fu" buildMode="Global" visible="1" canBeVaried="0" />
-          <Parameter id="Ywk4dNfVEUu8m7mo_malFQ" name="Blood/Plasma concentration ratio" description="Blood to plasma concentration ratio" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionInVitro_PKSim.PARAM_Blood2Plasma" buildMode="Property" visible="1" canBeVaried="1" />
-        </Children>
-      </GlobalMoleculeDependentProperties>
-      <TopContainers>
-        <Container id="_7RSv_STIUOcPonMKsM5yA" name="Organism" description="Organism" icon="Organism" mode="Logical" containerType="Organism">
-          <Children>
-            <Parameter id="kPqWxXZqf0KiLn6vGCXBxg" name="Specific clearance (endosome)" description="Specific endosomal clearance" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="Individual_PKSim.PARAM_CLSpec_endosomal_global" visible="1" canBeVaried="1" displayUnit="1/min" />
-            <Parameter id="YCkLx9EbAUGWge1sS7mBzQ" name="SA proportionality factor" description="Proportionality factor for the surface area plasma &lt;=&gt; int" persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" visible="0" canBeVaried="1" value="9500" displayUnit="1/cm" />
-            <Parameter id="qh_uWMytPEuRsSQBkvwO-Q" name="Volume (plasma)" description="Whole body plasma volume" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="Individual_PKSim.PARAM_VolumePlasma" visible="0" canBeVaried="0" displayUnit="l" />
-            <Parameter id="2jPy42SbDk23b_v6TOQXEA" name="Surface area scaling exponent" description="Global shape parameter; used (as exponent) for calculating diffusion stream between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-            <Parameter id="SHnmPWHyE0OFvACxy1H0Nw" name="Weight" description="Body weight" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="Individual_PKSim.PARAM_BW" visible="1" canBeVaried="1" displayUnit="kg" />
-            <Parameter id="CqAdr8WBk0Siq2GCDFQrvQ" name="Estimated gestational age" description="Estimated gestational age" persistable="0" isFixedValue="0" dim="Age in weeks" quantityType="Parameter" formula="GFR_Calculation.PARAM_PostMenstrualAge" visible="0" canBeVaried="1" displayUnit="week(s)" />
-            <Parameter id="k3y5bKD2ckShJ-5GsvxKOw" name="BMI" description="Body mass index" persistable="0" isFixedValue="0" dim="BMI" quantityType="Parameter" formula="BMI.PARAM_BMI" visible="1" canBeVaried="1" displayUnit="kg/m²" />
-            <Parameter id="Ae181Ld6c0Kksk3eawJkZw" name="Vf (neutral lipid, blood cells)-WS" description="Fractional volume content of neutral lipid in blood cells used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.003" />
-            <Parameter id="FsqcpzUYf0ezmagAaPFTsw" name="Vf (water,plasma)" description="Fractional volume content of water in plasma used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.926" />
-            <Parameter id="CbBSbGljZkGgTxiaOv4bEQ" name="Vf (water,interstitial)" description="Fractional volume content of water in interstitial space used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.935" />
-            <Parameter id="4IkIg96iYEiUnWsM7s2-RA" name="Vf (water,blood cells)" description="Fractional volume content of water in blood cells used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.625" />
-            <Parameter id="2uGzg-GenkmdSUS_Vb3ngQ" name="Vf (protein,plasma)" description="Fractional volume content of protein in plasma used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.067" />
-            <Parameter id="EaXehL1ul0ORkonn7tJ41g" name="Vf (protein,blood cells)" description="Fractional volume content of protein in blood cells used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.325" />
-            <Parameter id="mS6cURMNTUqykPJZ5ymdFQ" name="Protein ratio (interstial/plasma)" description="The ratio between the protein volume fraction in interstitial space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.37" />
-            <Parameter id="CD3EZjB050uzmzcTKrTQog" name="Vf (lipid, blood cells)" description="Fractional volume content of lipid in blood cells" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.005" />
-            <Parameter id="sTCeaQ0JOEO_nkJCnSwhuQ" name="Vf (lipid, plasma)" description="Fractional volume content of lipid in plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.007" />
-            <Parameter id="UXfk1_H7H06oWUUt1WgO1A" name="Vf (neutral lipid, plasma)-RR" description="Fractional volume content of neutral lipid in plasma used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0032" />
-            <Parameter id="QKxtZjvf506qD30Qrm8zQg" name="Thickness (endothelium)" description="Thickness of vascular endothelium" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="3E-06" displayUnit="cm" />
-            <Parameter id="V6iHmLMQg0Kmua5E5P-Bqw" name="pH (plasma)" description="pH of plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.4" />
-            <Parameter id="TCJyJmYcIU2H1yqKBNOdXQ" name="pH (blood cells)" description="Intracellular pH of blood cells" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.22" />
-            <Parameter id="x14okXjSBUOsO14DHmXMtQ" name="pH (interstitial)" description="pH of interstitial space" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.4" />
-            <Parameter id="SIU4L3vxK0e_qBzip0MsZQ" name="pH (intracellular)" description="pH of intracellular space" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7" />
-            <Parameter id="DgVhqpti9kulqKriQAP18A" name="R*T" description="Gas constant-body temperature product (37°C)" persistable="0" isFixedValue="0" dim="RT" quantityType="Parameter" visible="1" canBeVaried="0" value="928.8" displayUnit="N*cm/mol" />
-            <Parameter id="z1zl-fWlBk-pTBGswUDPAw" name="Na" description="Avogadro constant" persistable="0" isFixedValue="0" dim="Inversed mol" quantityType="Parameter" visible="0" canBeVaried="0" value="6.022E+17" displayUnit="1/mol" />
-            <Parameter id="lyZ2vzfG2Ue9AVRmp6XyLQ" name="Gestational age" description="Gestational age" persistable="0" isFixedValue="0" dim="Age in weeks" quantityType="Parameter" visible="1" canBeVaried="1" value="40" displayUnit="week(s)" />
-            <Parameter id="IHA8ehcfRk6x-_UO_gqOHQ" name="Age" description="Age" persistable="0" isFixedValue="0" dim="Age in years" quantityType="Parameter" visible="1" canBeVaried="1" value="30" displayUnit="year(s)" />
-            <Parameter id="a6g1Z2bfR0uECAzTb7yCVg" name="Fraction endosomal (global)" description="Fraction of endosomal space in vascular endothelium" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" visible="1" canBeVaried="1" value="0.2" />
-            <Parameter id="ne8Uhyg3cEin2FKViZ4odw" name="Vf (neutral lipid, plasma)-PT" description="Fractional volume content of neutral lipid in plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0035" />
-            <Parameter id="p1LqFXbVd0ebcKnR_7ca8Q" name="Vf (neutral phospholipid, blood cells)-WS" description="Fractional volume content of neutral phospholipid in blood cells used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0059" />
-            <Parameter id="5kkwsCA1e0iu5ouikNb5tA" name="Vf (neutral phospholipid, plasma)-RR" description="Fractional volume content of neutral phospholipid in plasma used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0021" />
-            <Parameter id="pOa9FRem9EWbAx-wJQvG7g" name="Surface/Volume ratio (blood cells)" description="Surface area to volume ratio of blood cells" persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" visible="0" canBeVaried="1" value="167000" displayUnit="1/cm" />
-            <Parameter id="0CowVQ8W706V2YoV38lrcQ" name="Vf (phospholipid, plasma)-PT" description="Fractional volume content of phospholipid in plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.00225" />
-            <Parameter id="o9Ag97rZCU6mDOEBuUzUgw" name="Vf (acidic phospholipids, blood cells)-WS" description="Fractional volume content of acidic phospholipid in blood cells used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.001" />
-            <Parameter id="vq2R3QjlUEiiVwV45BEJJQ" name="Vf (neutral lipid, blood cells)-RR" description="Fractional volume content of neutral lipid in blood cells used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0012" />
-            <Parameter id="k6TSjDbjeEGaiJORU-1pyw" name="Plasma protein scale factor" description="Scale factor for the fraction unbound in plasma. This factor can be used if changes in the plasma protein concentration and, as a result, in the plasma protein binding of the drug are expected due to e.g. ageing or certain diseases such as cirrhosis, sepsis, or renal failure" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="1" />
-            <Parameter id="hMK0NlPolkCefjsy_acsJQ" name="Fraction of endosomal uptake from plasma (global)" description="Fraction of drug uptake from plasma into endosomal space relative to total uptake from plasma and interstitial space" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-            <Parameter id="SGjiwkwIPk2MuP4RDUV5kA" name="Ontogeny factor (alpha1-acid glycoprotein)" description="Ontogeny factor (α1-acid glycoprotein)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-            <Parameter id="Gj2ZLAZookaSO1CK_l4QNg" name="Ontogeny factor (albumin)" description="Ontogeny factor (albumin)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-            <Parameter id="Xod_droqekqQcHs8397N2w" name="Height" description="Body height" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="16.996" displayUnit="cm" />
-            <Parameter id="SnaCUnG_bE23QwQvyBpttA" name="Vf (neutral phospholipid, blood cells)-RR" description="Fractional volume content of neutral phospholipid in blood cells used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0033" />
-            <Parameter id="Xg6W9oFyME2O5ArOgtCjVw" name="Vf (water,plasma)-PT" description="Fractional volume content of water in plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.945" />
-            <Parameter id="8yLzalc1JEi0Xak7CDxlbg" name="Acidic phospholipids (blood cells) [mg/g] - RR" description="Concentration of acidic phospholipids in red blood cells [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.57" />
-            <Parameter id="SfeS7Vkh-kq38B2zw0QgOw" name="Fraction recycled to plasma (global)" description="Fraction of drug recycling to plasma relative to total recycling to plasma and interstitial space" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-            <Parameter id="qATL0VQ9ZUad8zDgULojYA" name="Vf (intracellular water, blood cells)-RR" description="Fractional volume content of intracellular water in blood cells used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.63" />
-            <Parameter id="mlqY1SYhSkeR-a3lUkh8cg" name="Rate constant for endosomal uptake (global)" description="Rate constant for endosomal uptake for all organs" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" visible="1" canBeVaried="1" value="0.36" displayUnit="1/min" />
-            <Parameter id="IBDIrp7L406mxIhnEzm1hg" name="Rate constant for recycling from endosomal space (global)" description="Rate constant for recycling from endosomal space for all organs" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" visible="1" canBeVaried="1" value="0.083" displayUnit="1/min" />
-            <DistributedParameter id="2HRZYeG3kky1QL70qLOWWw" name="Hematocrit" description="Hematocrit" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="bhamT5cUME63nIB4NyPxUw" mode="Logical" visible="1">
-              <Children>
-                <Parameter id="gM89EtRIT0GrB3NujezUEA" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                <Parameter id="5aMJqeLatEeo901406jBJA" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.47" />
-              </Children>
-            </DistributedParameter>
-            <DistributedParameter id="anL-aVeRTkyDivEbJ0TlGQ" name="MeanBW" description="Weight" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="enditrKem0aMNbNd74qI7g" mode="Logical" visible="0" displayUnit="kg">
-              <Children>
-                <Parameter id="C5WpH25VpEeE5b2r3x1-gg" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" displayUnit="kg" />
-                <Parameter id="aomFscoBLEORQa77Kp1jWw" name="Mean" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" visible="0" canBeVaried="1" value="60.034" displayUnit="kg" />
-                <Parameter id="1VrLW6KOxEeCKaYdDfwKEQ" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" visible="0" canBeVaried="1" value="3.0017" displayUnit="kg" />
-              </Children>
-            </DistributedParameter>
-            <DistributedParameter id="aVu6Z6wQEkyM184xiuEi2Q" name="MeanHeight" description="Height" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="DYM7WGn-7kyvZN8Oq30NLQ" mode="Logical" visible="0" displayUnit="cm">
-              <Children>
-                <Parameter id="jKFjG9SPMEqkQRhAtWnwOw" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" displayUnit="cm" />
-                <Parameter id="s_16Tx64ZkO-h7xVcXc_3Q" name="Mean" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="16.996" displayUnit="cm" />
-                <Parameter id="t_SLJw4DK0Od6zhMRhPvwA" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.59486" displayUnit="cm" />
-              </Children>
-            </DistributedParameter>
-            <Container id="fTFGCLAcaU24atGRIlfo3Q" name="PeripheralVenousBlood" description="Peripheral Venous Blood" icon="VenousBlood" mode="Logical" containerType="Organ" />
-            <Container id="F39z2HCDsEulTYZYELHdog" name="VenousBlood" description="VenousBlood" icon="VenousBlood" mode="Logical" containerType="Organ">
-              <Tags>
-                <Tag value="BloodOrgan" />
-              </Tags>
-              <Children>
-                <Parameter id="73BbH8AAGEOYIoMY0--rcw" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="Individual_PKSim.PARAM_Tissue_Weight" visible="0" canBeVaried="1" displayUnit="kg" />
-                <Parameter id="v7qvrtwFVUO1nwLuUEd50A" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                <Parameter id="tc-i6fkZukqgORczlM1ijw" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="0" value="0.75" />
-                <Parameter id="RiP72T6Y4EysbUWSf40cdw" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="1" />
-                <DistributedParameter id="8CNqo0vlKUSEJ4bgtzxKgQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="qrigwKerfkanKkcesf7iiQ" mode="Logical" visible="1" displayUnit="l">
-                  <Children>
-                    <Parameter id="YnYKVVn4u0e-83so_yDOFA" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.501140854040494" displayUnit="l" />
-                    <Parameter id="LAqaqsREOU-4WwPOU3pcuQ" name="Mean" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" value="0.776531873" displayUnit="l" />
-                    <Parameter id="5LeIYvxfmEmA_FZ55t31Zw" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" value="0.038826594" displayUnit="l" />
-                  </Children>
-                </DistributedParameter>
-                <Container id="AsKjCr0qtU6a-XJrIrGPTA" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="BloodOrgan" />
-                    <Tag value="VenousBlood" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="WF6D6TKPxEOsARPPVus_Wg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="zeZ-3Cn9HUmyZc-zaXBFfQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_pls_BloodOrgan_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Container id="4TdstCp8dUWjwDmCTlpW4g" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Children>
-                        <Parameter id="WT7Dct9XbUS1bhPpqsWsww" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" visible="0" canBeVaried="0" />
-                        <Parameter id="x0brc9VbEkaFp-8u-BNerw" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="tLK5A0Qv_EaJTZDJ7FqJQA" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="BloodOrgan" />
-                    <Tag value="VenousBlood" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="PeBySdE5Q0KqMS22Cccrdw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="w3MCaB3OEkmayKsA6evd4A" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_bc_blood_organ_4comp" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Container id="iFBmy8AZ-kqE_6drsy7dgg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Children>
-                        <Parameter id="QEV4afEIiUyovfGkA6BvXg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" visible="0" canBeVaried="0" />
-                        <Parameter id="xMZCWbiQYEmzChx8-G633g" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-              </Children>
-            </Container>
-            <Container id="J4fZwXKgB0aTLtAzGj0RZw" name="ArterialBlood" description="ArterialBlood" icon="ArterialBlood" mode="Logical" containerType="Organ">
-              <Tags>
-                <Tag value="BloodOrgan" />
-              </Tags>
-              <Children>
-                <Parameter id="wu9PzBhNmkOSWo6HvS9U8w" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="Individual_PKSim.PARAM_Tissue_Weight" visible="0" canBeVaried="1" displayUnit="kg" />
-                <Parameter id="P_PD3IimwUesolj33v1aLQ" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                <Parameter id="oeROAGxqR0uINO5YLBdU1Q" name="Peripheral blood flow fraction" description="Blood flow fraction in organ used for calculation of peripheral venous blood concentrations" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" visible="1" canBeVaried="1" value="0" />
-                <Parameter id="kRrheAR-vESFGALYluAW4w" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="0" value="0.75" />
-                <Parameter id="GhkH1_3g5kq9aVclw1a9YQ" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="1" />
-                <DistributedParameter id="5YUx9dPBrkyYHP-qJmRWrg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="yLnuftcCTE2lwlnsVaJklA" mode="Logical" visible="1" displayUnit="l">
-                  <Children>
-                    <Parameter id="nq40PxbrzU2k1DQopXmFIw" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.500575515426459" displayUnit="l" />
-                    <Parameter id="MPBkmMqofkaxCHk9PxX2lg" name="Mean" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" value="0.337622553" displayUnit="l" />
-                    <Parameter id="-oqHOcpm80WezJvlbq8K8g" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" value="0.016881128" displayUnit="l" />
-                  </Children>
-                </DistributedParameter>
-                <Container id="B0yJEO0-kUqHLgCh369ADQ" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="ArterialBlood" />
-                    <Tag value="BloodOrgan" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="Muxat8FaRkaVR9biLxjTzw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="2rHDdaM8i0iW0UFKnfxOxg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_pls_BloodOrgan_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Container id="pQQ8UjV7b0ql0pltZr4l-g" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Children>
-                        <Parameter id="UQxH0DcXkU-n0tT4zljdxg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" visible="0" canBeVaried="0" />
-                        <Parameter id="9hWy9xXTY0y6irTQI4JOvA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="BuQVS6yXyUaIq4-4XAWfSA" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="ArterialBlood" />
-                    <Tag value="BloodOrgan" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="gXJFpuAfm0yN1B6lJrsqRA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="utQaY84PKkGj_2PJEhBJ3w" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_bc_blood_organ_4comp" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Container id="tFTgHoJI3EuKywntKQRclw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Children>
-                        <Parameter id="QnNO9wKF_Ei_LDRPA_0BVg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" visible="0" canBeVaried="0" />
-                        <Parameter id="vW89Z8gnGEC4M9fL4fvKEA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-              </Children>
-            </Container>
-            <Container id="EOCNYCiyR0-ddQmB3lY2mg" name="Gallbladder" description="Bile compartment used to collect excretion to the bile" mode="Physical" containerType="Organ">
-              <Tags>
-                <Tag value="Liver" />
-              </Tags>
-              <Children>
-                <Parameter id="xEC-oe1hCUq3-G3pe4PZJQ" name="Gallbladder emptying rate" description="Rate of gallbladder emptying" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" visible="0" canBeVaried="0" value="0" displayUnit="µmol/min" />
-                <Parameter id="D94A2TkTR0agmYu5SaArmg" name="Time to complete gallbladder refilling" description="Time to complete gallbladder refilling" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" formula="Individual_PKSim.PARAM_GallbladderRefillTime" visible="1" canBeVaried="1" displayUnit="min" />
-                <Parameter id="N1ZVoSGBZUORG3HELRHQAQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="l" />
-                <Parameter id="SWAUNrchVUS4gdDk_Osy6Q" name="Gallbladder ejection half-time" description="Gallbladder ejection half-time" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" visible="1" canBeVaried="1" value="19.7" displayUnit="min" />
-                <Parameter id="nAjaD3F6l0mUFE_V2IuSwQ" name="Gallbladder ejection fraction" description="Gallbladder ejection fraction" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" visible="1" canBeVaried="1" value="0.65" />
-                <Container id="mpCD2xaYUU-WZ9NQCp6VRg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule" />
-              </Children>
-            </Container>
-            <Container id="z7QbBzDQ8Uin2-FpKLR5DA" name="Bone" description="Bone" icon="Bone" mode="Logical" containerType="Organ">
-              <Tags>
-                <Tag value="TissueOrgan" />
-              </Tags>
-              <Children>
-                <Parameter id="FAeHmJyAzE-zRaeJ_OHTjg" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="Individual_PKSim.PARAM_Tissue_Weight" visible="0" canBeVaried="1" displayUnit="kg" />
-                <Parameter id="jIcw9CBzr0i5FEH7Ef99KQ" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Q_from_Qspec" visible="1" canBeVaried="1" displayUnit="l/min" />
-                <Parameter id="pjBynKWF80-48cGvGxePhg" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate_Bone" visible="1" canBeVaried="1" displayUnit="l/min" />
-                <Parameter id="Ft0Vnl2YqkGf1x1nVdaY_A" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Lymph_flow_rate_Bone" visible="1" canBeVaried="1" displayUnit="l/min" />
-                <Parameter id="4_6NnMBkZkKVtXuTK1FUcQ" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="VascularEndoVolume.VOLUME_VascularEndo_bon" visible="1" canBeVaried="0" displayUnit="l" />
-                <Parameter id="1gldi4QKlEi5fqGrFITwZA" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_f_cell" visible="1" canBeVaried="1" />
-                <Parameter id="KLh73v2hqkSIIQjdIlOX3A" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                <Parameter id="URjojN2idkC-HkzJKzwpvw" name="Peripheral blood flow fraction" description="Blood flow fraction in organ used for calculation of peripheral venous blood concentrations" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" visible="1" canBeVaried="1" value="0" />
-                <Parameter id="GSxSvXu9SUKNukYDib82TQ" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="2" />
-                <Parameter id="Hu6_cNxVrUKoXqpfdVEuhA" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                <Parameter id="njaK2nkOIE2bAhMtDgnHww" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.8" />
-                <Parameter id="2LBPaE5s-0-GhUB11j3xoA" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="3.3E-07" displayUnit="µm" />
-                <Parameter id="X3T4vyYV1Ee1uCPsnEqsjA" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="9E-08" displayUnit="µm" />
-                <Parameter id="LST0KilxYU-HfRnIF1mkEw" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" visible="1" canBeVaried="1" value="3.88888888888889E-11" displayUnit="ml/min/N" />
-                <Parameter id="g9XCAlP9X0OPzeRc3K6VWg" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.074" />
-                <Parameter id="nRbcWVqWVUedsfOKCQuH0w" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.268" />
-                <Parameter id="Tkgg3UMDukipsmSy35NsHw" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.034" />
-                <Parameter id="23M8M57WgkKcfX82Jv--9Q" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.268" />
-                <Parameter id="YwYZl3EJeECrt9EUxzRNGA" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0011" />
-                <Parameter id="4mf6jsmcek6e4MWcJ9LdGw" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.1" />
-                <Parameter id="wVNEl0TK7ES1TafMBH1W3w" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.05" />
-                <Parameter id="JL_HGCYdqEu3YMAp1mlfdg" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.465" />
-                <Parameter id="8iWOmnc5W0GcBUYMHh8U_w" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.439" />
-                <Parameter id="AT_NvqxMWEi8U5FbWAyMng" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-                <Parameter id="JkW7ZjNIC06VSV49s8bRwQ" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.1" />
-                <Parameter id="-hRNpSl8DkCm7jdQWlk7VA" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.017" />
-                <Parameter id="TmeI5p7YYkilllQWkev1pg" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0174" />
-                <Parameter id="oyHEcV8DLkOfwjoztA7LTA" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0016" />
-                <Parameter id="rvllfmbvSEC6YC5mtJO6ug" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0022" />
-                <Parameter id="bTOO2nxOG0qUORvAAiEYSw" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.1" />
-                <Parameter id="7Mi57nHVjkm-kaiQw-UzQA" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.21" />
-                <Parameter id="GlazJjO8dESOP628NUZsIA" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.26" />
-                <Parameter id="Adz57oJ6Yke9pUVH3nlb0w" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.317" />
-                <Parameter id="z3kyesfewkOw8B7SR5ggmw" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0008" />
-                <Parameter id="VTsxpEFRkEKfOLhfAVTyfw" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.67" />
-                <DistributedParameter id="ZHXIerd5i0eoAzTtxPFLFA" name="Specific blood flow rate" description="Blood flow rate normalized to the organ volume" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" formula="-4pssNO3QEOh8l6J5tNBFQ" mode="Logical" visible="1" displayUnit="ml/min/100g organ">
-                  <Children>
-                    <Parameter id="-S1NB7v_jU6qFn0rWD3MyQ" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" displayUnit="ml/min/100g organ" />
-                    <Parameter id="mJ-qr3ojr0i83kwWBDEQDg" name="Mean" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" visible="0" canBeVaried="1" value="0.027495" displayUnit="ml/min/100g organ" />
-                    <Parameter id="TZPPDzZDakWEHA5tSyKO5w" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" visible="0" canBeVaried="1" value="0.00137475" displayUnit="ml/min/100g organ" />
-                  </Children>
-                </DistributedParameter>
-                <DistributedParameter id="cNs43HujM0W-dcQTRamN3w" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="WkjshN5q50W0GB-WhfeWfw" mode="Logical" visible="1" displayUnit="l">
-                  <Children>
-                    <Parameter id="AEnksmcHDEGw9kr8EdWS0w" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.50325782866479" displayUnit="l" />
-                    <Parameter id="E9fahDb7PUm7GTpViIL1wQ" name="Mean" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" value="9.5207652443088" displayUnit="l" />
-                    <Parameter id="QPQ7QHqBh0OMW0diW0CriA" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" value="0.105290142836811" displayUnit="l" />
-                  </Children>
-                </DistributedParameter>
-                <Container id="5qhBG-74sEmSAgcDLdsKOw" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Bone" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="1v8evC1C70S1i_IssxvFyg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="jLHmUFBY0kOX8VQnUsAdsQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Container id="MfieV5G-okK_MMHvu7tCkQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Children>
-                        <Parameter id="BItvf9_mdUq3ISiln5ePDw" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                        <Parameter id="ymhkG3mbwUmDmz99u4gevQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" visible="0" canBeVaried="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="FJ8onNQ3S0m05n8qe_e3lQ" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Bone" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="WOqYFzTgT064wxkN-IWsGw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="_uQ26MeZAkKQjITKebIu_g" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Container id="B1n2WYi-ZkaOx0w7wlmWAw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Children>
-                        <Parameter id="b6LmLWIV4kePfcI2QiEdHw" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                        <Parameter id="Rjuv4hCMtEiKZmtcUDpzDQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" visible="0" canBeVaried="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="I4hGcwkmzkmEz3yfrqW3BQ" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Bone" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="dBpsGKbU8kanpCv7CXIFDg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="Oz5_YV_Rf0y3W_l5FteqcQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Parameter id="unM7mlhHFUyBKPSy8cG5Cg" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_pH_INT" visible="1" canBeVaried="1" />
-                    <Container id="9nh50ju3xkutGxhJ0FspbQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Children>
-                        <Parameter id="nJMstMtwsEKJFGoLJx1YjA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                        <Parameter id="n0ImzFPySUKRpIXmmP4kFg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_bon" visible="0" canBeVaried="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="XBQCWlrnIU6dG_CYS9pmbQ" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Bone" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="eeSYqSQJJkWZ7YUsYSC5qA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="hV_fwpqwD06bmOAavWP3aQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Parameter id="j_FqK7kwkkWSXJ9Jh8cUmA" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7" />
-                    <Container id="VALO5s62DkSWx9H6V2qUqg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Children>
-                        <Parameter id="fp6OJDn9Tkuo-9Prrur7Iw" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                        <Parameter id="KU97o2iklUuh-7XOz3wmKA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_bon" visible="0" canBeVaried="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-              </Children>
-            </Container>
-            <Container id="Hu4Nl2C_d0OozLJSUsk5Ug" name="Brain" description="Brain" icon="Brain" mode="Logical" containerType="Organ">
-              <Tags>
-                <Tag value="TissueOrgan" />
-              </Tags>
-              <Children>
-                <Parameter id="P4YQN15cfUyZIyEkNbzyDg" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="Individual_PKSim.PARAM_Tissue_Weight" visible="0" canBeVaried="1" displayUnit="kg" />
-                <Parameter id="a8ZLx4Tx9U-sVYrN0k-MKQ" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="VascularEndoVolume.VOLUME_VascularEndo_brn" visible="1" canBeVaried="0" displayUnit="l" />
-                <Parameter id="KwYFh18AiUidLnLmdMen2Q" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Lymph_flow_rate_Brain" visible="1" canBeVaried="1" displayUnit="l/min" />
-                <Parameter id="l9bM30P1h0m6z6pIYStWhA" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate_Brain" visible="1" canBeVaried="1" displayUnit="l/min" />
-                <Parameter id="5SFQMTmcdEaquhhvAWEXug" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_f_cell" visible="1" canBeVaried="1" />
-                <Parameter id="1Zx3IBbSlEyaGX_0TLCZxA" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Q_from_Qspec" visible="1" canBeVaried="1" displayUnit="l/min" />
-                <Parameter id="45XYtXcKXk-3EmPW527iCw" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                <Parameter id="12WJ_NWsIU262ZSOiJugNw" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0" />
-                <Parameter id="s7m_VOJqAUuxWL-3imGC9g" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                <Parameter id="HESqM7zGr0yO85NJCvfFTA" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.05" />
-                <Parameter id="OssyXdSUdUi5-zz29GR-ew" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" visible="1" canBeVaried="1" value="5E-14" displayUnit="ml/min/N" />
-                <Parameter id="o37r8TDox0mLpSqBiHyDvQ" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="2.5E-07" displayUnit="µm" />
-                <Parameter id="g7-6l0yBZEq9U-a4EZjLUw" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="4.5E-08" displayUnit="µm" />
-                <Parameter id="Gtj-jCBr2UiRvi91JgVnpw" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.051" />
-                <Parameter id="ueZS7l61gEOuIM4zQilv5A" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.11" />
-                <Parameter id="M1SinE4S7UeC6WDwxD9U0w" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.039" />
-                <Parameter id="uYv4GnccGEyk3ooC9qVhMQ" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0565" />
-                <Parameter id="EK-IpTeqCkuQ2diZgsbjNQ" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.081" />
-                <Parameter id="lgrdN7PHlEyR22_v37qqSw" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.77" />
-                <Parameter id="KPAP8fduEEmI-UqAWrOfqQ" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-                <Parameter id="Q0sIk_LhU0KxWFHWGlgn2Q" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.808" />
-                <Parameter id="fbplvI-tsUy4zZ3Eh5LFow" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.048" />
-                <Parameter id="rPLqZtLidUKivj9Hxd1fZw" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.041" />
-                <Parameter id="JqKKD58gu0aGOZEeS209VQ" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.004" />
-                <Parameter id="Bj6ab8H6eEKnWjBJticpvQ" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0391" />
-                <Parameter id="HrNakzJLq0OmakNUXeQ4iQ" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0429" />
-                <Parameter id="XgIRvdEf2kyThRa5gTO1bQ" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0015" />
-                <Parameter id="2bG3EdVNu0qwMq3NJsIWKw" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0528" />
-                <Parameter id="Br1tGXbdxkKxXFb6e52fwg" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.08" />
-                <Parameter id="kjlmkQWYFUCtv1bU9g8oVA" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.162" />
-                <Parameter id="IKsI26iLr060doKzi_7LyA" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.591" />
-                <Parameter id="ESRo9Knyc0mt3tyd1ijoPg" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.79" />
-                <Parameter id="9S0wQF7hREiBSTIkzanc4Q" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.4" />
-                <Parameter id="kMnCYjLkMUSIzTHClIlo8w" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0143" />
-                <DistributedParameter id="uNN_Mg4gaEGEnG1u3pIs6Q" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="BBLlW0uIRUGzSS_KEbyTbg" mode="Logical" visible="1" displayUnit="l">
-                  <Children>
-                    <Parameter id="EuI_1KdCU026bVnWPjT-Pw" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.501934930268944" displayUnit="l" />
-                    <Parameter id="YXMNq-sEj0Cd5YkpfRvaTg" name="Mean" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" value="1.5088" displayUnit="l" />
-                    <Parameter id="J2s59nOgXEO5tt8XuHd5Fw" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" value="0.07544" displayUnit="l" />
-                  </Children>
-                </DistributedParameter>
-                <DistributedParameter id="2GzuVTQaV0m31KiQXdfSSQ" name="Specific blood flow rate" description="Blood flow rate normalized to the organ volume" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" formula="P8yWDs2VXkqKpDbbuAHuBA" mode="Logical" visible="1" displayUnit="ml/min/100g organ">
-                  <Children>
-                    <Parameter id="Egx_h9wOwk-R0zhbRDBSAw" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" displayUnit="ml/min/100g organ" />
-                    <Parameter id="qDXg4oYtJEKIX4yd15PXAA" name="Mean" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" visible="0" canBeVaried="1" value="0.51675" displayUnit="ml/min/100g organ" />
-                    <Parameter id="8Qzy3NwM5EKt4-6c_BmbsQ" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0258375" displayUnit="ml/min/100g organ" />
-                  </Children>
-                </DistributedParameter>
-                <Container id="DF7RMcQS5kelas00ZZs78w" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Brain" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="vpqYj8d2SkWMd4inhm107w" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="FznSmmCzkUu0ineaazHsfQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Container id="g3Ahvoo-GEy320ZDNZOiRA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Children>
-                        <Parameter id="GhaCjD_sCEu6Ma3Bjel0qg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" visible="0" canBeVaried="0" />
-                        <Parameter id="5_UQu8ZSp0mjgULgnrrpVQ" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="-hzUSP0H0UKYFyzMVYcHLg" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Brain" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="28pi619PW0e4IMxlz7UKSg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="SUzWVkoiAkCqrLECP76YFg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Container id="y7pUV7pVn0OutcWPUPx2Zw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Children>
-                        <Parameter id="m2k-4sE43EmK13Lr-LZwww" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                        <Parameter id="o6S3UvaWWkiUxtdAaPHvJw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" visible="0" canBeVaried="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="25_Mxy04OkmI2F3SSIcweg" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Brain" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="vF6Z3oagjEavYzw3Aut07Q" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="wNGrGtmfGEePLINRQumyzg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Parameter id="VkzGtuTAfUqnDNSDLGEQXA" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_pH_INT" visible="1" canBeVaried="1" />
-                    <Container id="SiYQSJav_0-8wYGuC_eKNQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Children>
-                        <Parameter id="qH_FdVjUUE6pKdcAlIuo0Q" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                        <Parameter id="o_t8zODSS0eTCAxkLkezWA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_brn" visible="0" canBeVaried="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="c_MXK797hEu3FFPNqIuxqA" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Brain" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="2tBObQSzO06BUI2izF7rKg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="HkmQNalDxkmZUCeW_EZBnw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Parameter id="NgYT-MinuEeImcxb76COzw" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.1" />
-                    <Container id="cE214kQokU-5VWWNHglyRQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Children>
-                        <Parameter id="Yw5OFU-rdkqQKiYcl-oudQ" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                        <Parameter id="VTFIu5hIDUOQVBNoJ6HlNQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_brn" visible="0" canBeVaried="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-              </Children>
-            </Container>
-            <Container id="3Ca8_d1pk0Slo8KZgKFTJA" name="Fat" description="Fat" icon="Fat" mode="Logical" containerType="Organ">
-              <Tags>
-                <Tag value="TissueOrgan" />
-              </Tags>
-              <Children>
-                <Parameter id="M5l30bsppk2EIQ4JRzFL8w" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="Individual_PKSim.PARAM_Tissue_Weight" visible="0" canBeVaried="1" displayUnit="kg" />
-                <Parameter id="csO12F9IlkG4BcNnYKiNuA" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate_Fat" visible="1" canBeVaried="1" displayUnit="l/min" />
-                <Parameter id="QAadygNxhkGi6T6Ok_tGzQ" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Lymph_flow_rate_Fat" visible="1" canBeVaried="1" displayUnit="l/min" />
-                <Parameter id="hcwxhH3_4E-c71eYtto25g" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="VascularEndoVolume.VOLUME_VascularEndo_fat" visible="1" canBeVaried="0" displayUnit="l" />
-                <Parameter id="Q6dFY7rtYU-eeMix3lyN_w" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_f_cell" visible="1" canBeVaried="1" />
-                <Parameter id="35bpohQN9E--pGe1VxMU3A" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Q_from_Qspec" visible="1" canBeVaried="1" displayUnit="l/min" />
-                <Parameter id="nNR6sahrHky6zS-8WTIQNg" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                <Parameter id="hvX-ebbQkEasVrcGp7cuaw" name="Peripheral blood flow fraction" description="Blood flow fraction in organ used for calculation of peripheral venous blood concentrations" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" visible="1" canBeVaried="1" value="0" />
-                <Parameter id="oVrAlF40lkuqnYLFTnp8qQ" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="2" />
-                <Parameter id="B4wFAhQeQkekF94PbDsoNQ" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                <Parameter id="ANDaoxz2IUKte-229nhXqg" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="2.5E-07" displayUnit="µm" />
-                <Parameter id="P9Q-HIGpn0mlfsIWhXlzGw" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.05" />
-                <Parameter id="2eTgbnqsM0Kduwq-Pozw6A" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" visible="1" canBeVaried="1" value="4.16666666666667E-12" displayUnit="ml/min/N" />
-                <Parameter id="zzWg3fQbGkqsEjERXthp5A" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="4.5E-08" displayUnit="µm" />
-                <Parameter id="gf8--Z-HXUSlMp1cnOUTNg" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.018" />
-                <Parameter id="q0ZvFNNke0yHiLNctLtobg" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.05" />
-                <Parameter id="8wVw0N8Ux0Sh10QufPP75A" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.068" />
-                <Parameter id="xxr_xoXyPUWPKywm_cd2wA" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.049" />
-                <Parameter id="AB7lgnqZ0UuXqfkHpgI8sg" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0" />
-                <Parameter id="wsOhgIOopkuffgBYrqiyhQ" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.06" />
-                <Parameter id="l6vPBnUS002PpHMR8IkMgA" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.4" />
-                <Parameter id="6D62AALCMUWr9OhUdRiaRw" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.000552" />
-                <DistributedParameter id="2didNNrQ7UeSGI58gwbA6w" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="rMdtikJs7EutBRJy4COPQg" mode="Logical" visible="1" displayUnit="l">
-                  <Children>
-                    <Parameter id="W-N1CtlXIEGs29vEtFXcjQ" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.489059629117061" displayUnit="l" />
-                    <Parameter id="e53TzNJoIUaytUJgRyZq9g" name="Mean" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" value="12.90800272" displayUnit="l" />
-                    <Parameter id="6yrc4TzT5E2s6FzQLl3iwQ" name="GeometricDeviation" description="Geometric standard deviation of LogNormal distribution" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1.5" />
-                  </Children>
-                </DistributedParameter>
-                <DistributedParameter id="w57fKFOa4UqHd59kjYzWKw" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="hqBCapFM1UGguLxHYJVa6A" mode="Logical" visible="1">
-                  <Children>
-                    <Parameter id="BF-RGlx0m0aEJkrGEaXb5g" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                    <Parameter id="Y1FqzOM_lEW1duOGArY39g" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.8" />
-                  </Children>
-                </DistributedParameter>
-                <DistributedParameter id="o7hPxRnr-EiEtuN3mjAkuQ" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="F9RIHC6AF0mX_l73piUBbQ" mode="Logical" visible="1">
-                  <Children>
-                    <Parameter id="Cdb8-eZsFE-OdXCr4ItnCQ" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                    <Parameter id="VS4n53clkEeeNNF4d61CIg" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.79" />
-                  </Children>
-                </DistributedParameter>
-                <DistributedParameter id="u0IeFwze1ESG-mgJ-pVdaQ" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="YjNztcDZbkidwTTj7Q3SRw" mode="Logical" visible="1">
-                  <Children>
-                    <Parameter id="P8aUzpX2wUGcMt6Ynwfjfw" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                    <Parameter id="cq0wzPZIiUur5Puz1y0kVQ" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.002" />
-                  </Children>
-                </DistributedParameter>
-                <DistributedParameter id="t1gUCH-agEusVDTlwl2ihQ" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="5yHmWqIAr0GS1oQ1C-FCqg" mode="Logical" visible="1">
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-                <DistributedParameter id="OyNajD8RO0W_DEt-r4pGlg" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="iVhaR6qEwkO89jGuDv8c4A" mode="Logical" visible="1">
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-                    <Parameter id="Epwow-boakqf2qzhjxKbjQ" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
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-                <DistributedParameter id="4AzZ2WEzo0qFjCtkUn3Z5w" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="d9PK9YENQku17Tv3eOF8dg" mode="Logical" visible="1">
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-                    <Parameter id="wsqDoZAP0UmGe4y9rzq2qw" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                    <Parameter id="ote5drPprkSA4gW3pKHmrQ" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.002024" />
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-                <DistributedParameter id="EH0pWCd-MESl83BUDq0Mig" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="unN-dDSyqUS7_pEwdhsjzw" mode="Logical" visible="1">
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-                <DistributedParameter id="D72mZRORSUeMuYkziHmLwg" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="LJoBvaYl6UKHVJKA-t3ABA" mode="Logical" visible="1">
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-                    <Parameter id="kpojh6OgcUOLkyiHj7bd8g" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
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-                <DistributedParameter id="pFxxm4iKdU-JrZSqRNg3Rg" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="UIFIvyKpwkWZLpPNZR7ycQ" mode="Logical" visible="1">
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-                <DistributedParameter id="D3gRib-xy0yVrDzSLQTanQ" name="Specific blood flow rate" description="Blood flow rate normalized to the organ volume" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" formula="akpIA4gEe0Ox1FRJ2gaQeA" mode="Logical" visible="1" displayUnit="ml/min/100g organ">
-                  <Children>
-                    <Parameter id="xr0iUhrZcEmJu1xC1g-B6Q" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" displayUnit="ml/min/100g organ" />
-                    <Parameter id="E-2POtPjOEWxuIEhesS5PQ" name="Mean" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" visible="0" canBeVaried="1" value="0.02184" displayUnit="ml/min/100g organ" />
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-                <Container id="T_1TMJYsE0yHE_9nhhc74Q" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Fat" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="3B4hfskURUC3RNwgDwdIJQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="v7hWOLFt6kuM5gfFwJhKiA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Container id="Dm3x7M7ypU6QC1OveoHUGA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Children>
-                        <Parameter id="vqzfGjlQJU62i4xYUF7Yjg" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                        <Parameter id="n8hg8Rc8YkynZn7LNFAHdA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" visible="0" canBeVaried="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="x2EBR2z3O02CQY3uNWAaxQ" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Fat" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="OoXDowsOCkiEETI0M1GuPA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="3AtxvEE3MEmWsk0DoPMDGA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Container id="AXyHJrrBp0ygxC4rE7wTYw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Children>
-                        <Parameter id="hZ0BZlsxSUKey4Wpp1IbFA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                        <Parameter id="PhwbHxH-i0qMbf44DYu08w" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" visible="0" canBeVaried="0" />
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-                </Container>
-                <Container id="uQu41YcHdk2JY4jt_EwoQA" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Fat" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="NgMCcSPYwE6JQ430pfFzZQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="Jil0gdBUUUGT3ovFvb8fBw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Parameter id="FHO_4tkVIUeRgVBXD7ckww" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_pH_INT" visible="1" canBeVaried="1" />
-                    <Container id="FcJX7HhmJES3h-e8EumhUw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Children>
-                        <Parameter id="7PXGpZcoLkyzlGLzpqMMIA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                        <Parameter id="6SdxMFPbHk-xZzvwMxMUtQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_fat" visible="0" canBeVaried="0" />
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-                </Container>
-                <Container id="VDtCW9Mz2UK58etDrlERew" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Fat" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="UW_pFvve30aDatty7OCVdg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="DVqIOT4R8ESl-wUlqrUKxQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Parameter id="TyOJn_l7zE6cGHyfEwqUHA" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.1" />
-                    <Container id="EBxhThqJLkO_WoYJ5yo3sA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Children>
-                        <Parameter id="h_nnqVi0Zk2p4Lx52WddmA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                        <Parameter id="sx-XfZ72lkS7YQ7PQzaOhg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_fat" visible="0" canBeVaried="0" />
-                      </Children>
-                    </Container>
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-                </Container>
-              </Children>
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-            <Container id="JXe0Cdkui0Oz7XJfrmgKSA" name="Gonads" description="Gonads" icon="Gonads" mode="Logical" containerType="Organ">
-              <Tags>
-                <Tag value="TissueOrgan" />
-              </Tags>
-              <Children>
-                <Parameter id="vIXwn8ZY7U-0MlBGMWUw_Q" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="Individual_PKSim.PARAM_Tissue_Weight" visible="0" canBeVaried="1" displayUnit="kg" />
-                <Parameter id="CmVbGsIJBkSzbKEZ3Lv8JQ" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="VascularEndoVolume.VOLUME_VascularEndo_tes" visible="1" canBeVaried="0" displayUnit="l" />
-                <Parameter id="eH-w-bWoqEa5yk9Y-bMdHA" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Lymph_flow_rate_Gonads" visible="1" canBeVaried="1" displayUnit="l/min" />
-                <Parameter id="Q7U1xQI9t0OUw9x9MDgxug" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate_Gonads" visible="1" canBeVaried="1" displayUnit="l/min" />
-                <Parameter id="4yLzuJkO5kSpoJjmgL-TdA" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_f_cell" visible="1" canBeVaried="1" />
-                <Parameter id="t4-QvfXxtEeYrCu4uHrqlw" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Q_from_Qspec" visible="1" canBeVaried="1" displayUnit="l/min" />
-                <Parameter id="ebuJtdwTWEm0v9405pOFTg" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                <Parameter id="uH45bRp8RUm67gyVxXfxjQ" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.75" />
-                <Parameter id="Ub53UnkaUUmSCZKxpfZnAA" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                <Parameter id="EESG578dVUup9ANntI38GQ" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="2.5E-07" displayUnit="µm" />
-                <Parameter id="d4bmWabUVUWfcm0ITrz9yg" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" visible="1" canBeVaried="1" value="1.66666666666667E-12" displayUnit="ml/min/N" />
-                <Parameter id="iDWQOV6rBEanXhY7l8OT5Q" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.05" />
-                <Parameter id="vmhEUGR1WUeHyJyRbqPvDg" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="4.5E-08" displayUnit="µm" />
-                <Parameter id="wxR4Qhyp-E-M79ZfSGKoHA" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.031" />
-                <Parameter id="Zhp0_DkNy0yrtWqYnE_kcQ" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0048" />
-                <Parameter id="di3C4uzGyUOjh2DqsnpkKQ" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.055" />
-                <Parameter id="8RKeNZHKFEOamJ9Ee6DHOQ" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.12" />
-                <Parameter id="rNFYd4GqbEulYkOa1fwPqg" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.01405" />
-                <Parameter id="oyMi9UVCbUy1j-cJcF6NhQ" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.048" />
-                <Parameter id="KZBI0iTYuE2ufBE9i5nu_w" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.041" />
-                <Parameter id="F05AvMZKika6LtGp3rw9xw" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-                <Parameter id="mX2goQ_yykOHJKY2Iqy2GQ" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.8" />
-                <Parameter id="q4IYM_4uQ0aeqzxWcztk7g" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.8" />
-                <Parameter id="Hq8D7wlRc0-HSkaEhmq5-A" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.069" />
-                <Parameter id="iUAIHRlXO0e0SQmti7U-hw" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0" />
-                <Parameter id="U0CTQ8cIDkGZ-mSMiXDBww" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0048" />
-                <Parameter id="WWh9qNcoXUOwudAfA-SImQ" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0116" />
-                <Parameter id="nFvuyrN6SEe9RPpzXiPUHg" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0249" />
-                <Parameter id="jUfsB_ZOnkSbm5UoVSGm4w" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.13" />
-                <Parameter id="-EMJD7FXT0KcBS4uLPF_zw" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.03" />
-                <Parameter id="ltfbkXRFwkijx-SU6ETBXA" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.83" />
-                <Parameter id="AVZlLLIHWEG2udq4onPBug" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.78" />
-                <Parameter id="XgUm5SFo9USlJVnYD3sUXw" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0054" />
-                <Parameter id="-IRhxv8dZ0uvo70OEsV9Ng" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="2.45" />
-                <DistributedParameter id="gCDA0jugWkOaEGqgpYMZRw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="mSj40SQyuk2DMn7sGyBJRg" mode="Logical" visible="1" displayUnit="l">
-                  <Children>
-                    <Parameter id="aiUJVPLDx02aHzFHuhj1Wg" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.49986860203947" displayUnit="l" />
-                    <Parameter id="epk90f4Mb0ySnFyPR5iAqQ" name="Mean" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0324411260176448" displayUnit="l" />
-                    <Parameter id="tFrkfPfwKUiv0k_4jXL1jA" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" value="0.00162205630088224" displayUnit="l" />
-                  </Children>
-                </DistributedParameter>
-                <DistributedParameter id="h4OQGC7Tu0GA7b4UU9R54g" name="Specific blood flow rate" description="Blood flow rate normalized to the organ volume" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" formula="cj-TAhD3LEaDVgX74HalTw" mode="Logical" visible="1" displayUnit="ml/min/100g organ">
-                  <Children>
-                    <Parameter id="94lpVW57REu2HREAfEiYSg" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" displayUnit="ml/min/100g organ" />
-                    <Parameter id="f_zxccdI0kOT6ey7uwcwqA" name="Mean" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0806" displayUnit="ml/min/100g organ" />
-                    <Parameter id="cqNLAuXqF0qRaoDn5jp6aA" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" visible="0" canBeVaried="1" value="0.00403" displayUnit="ml/min/100g organ" />
-                  </Children>
-                </DistributedParameter>
-                <Container id="WeKcMw4iF0S7FmaFEOg7rA" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Gonads" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="rVjz_sgbHU6Uviz-n0Xr9w" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="RJ0r4R_dEUeb46kSIqXgrA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Container id="k6udlQ5O6kqNuAjW1ak82A" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Children>
-                        <Parameter id="_cvJ8lLloEaFlvT7qoMomg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" visible="0" canBeVaried="0" />
-                        <Parameter id="p4ARvq5ByE-z8nwyxfJkYA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="lJHKHjIq9ESo-oG4BuGNgQ" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Gonads" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="IcnXiPZCDU6KB8-L1KSqFA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="MVY-BKt-aUKFpKoVXAOqWw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Container id="wci1-tFVEU65OLAVXkgMFw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Children>
-                        <Parameter id="bggfJ07EOES0fjBeDXBacg" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                        <Parameter id="OszMQPMcgk-25DqlmV0_jw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" visible="0" canBeVaried="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="1IHG4DNKOUePTVwBu4nQrw" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Gonads" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="6ITfvf2u4EyxniMHKFDfCw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="bXvm96igX02YWTfokpBl8Q" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Parameter id="jDdmj1cmSEajhJ7yoT1F2Q" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_pH_INT" visible="1" canBeVaried="1" />
-                    <Container id="VEwmdTXIN0uEYIp0cu3wog" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Children>
-                        <Parameter id="ncaCr2Tv0EOt4mH7YuIkWw" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                        <Parameter id="5OP5H364MEO9zee-4Qo1Qg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_tes" visible="0" canBeVaried="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="RR9zSg1yNUKN633IoKuRDw" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Gonads" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="8-qoiNTqu0mriib7kYe9hA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="pCG7LWjaOk-COiDCm7fweQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Parameter id="NjrJS7osO0agNhfQWgyRSg" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7" />
-                    <Container id="Vo1DBVHlx0m8BtyBGWmR-g" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Children>
-                        <Parameter id="ptBFh3sdjEG8uD9_X98DSA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_tes" visible="0" canBeVaried="0" />
-                        <Parameter id="_nlP9o08yE2Q8aN_mtkt5A" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-              </Children>
-            </Container>
-            <Container id="pgmTt6HfKUazKkVva3DmQw" name="Heart" description="Heart" icon="Heart" mode="Logical" containerType="Organ">
-              <Tags>
-                <Tag value="TissueOrgan" />
-              </Tags>
-              <Children>
-                <Parameter id="rIDqUuTdHka88jqzrY03XQ" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="Individual_PKSim.PARAM_Tissue_Weight" visible="0" canBeVaried="1" displayUnit="kg" />
-                <Parameter id="Go846w-spk2Ab-l3C6nkcw" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="VascularEndoVolume.VOLUME_VascularEndo_hrt" visible="1" canBeVaried="0" displayUnit="l" />
-                <Parameter id="WIXEKMVenkqfISsODqTmvg" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Lymph_flow_rate_Heart" visible="1" canBeVaried="1" displayUnit="l/min" />
-                <Parameter id="RONrMK4Tpk2LQwQUIcjfkg" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate_Heart" visible="1" canBeVaried="1" displayUnit="l/min" />
-                <Parameter id="ix6QowhyzU-BYJZGdSlSig" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_f_cell" visible="1" canBeVaried="1" />
-                <Parameter id="J8sbiFQAQkqAxP0kvZwX9g" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Q_from_Qspec" visible="1" canBeVaried="1" displayUnit="l/min" />
-                <Parameter id="rVCicPcnMECfcmH79lDx2g" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                <Parameter id="0ExBDqXPCEOx7HtM6na-aQ" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.75" />
-                <Parameter id="mser-3Rz9UarobSd6Oy_Ug" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                <Parameter id="hwo2FLAeF0SMoH6mzXtzDQ" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="2.5E-07" displayUnit="µm" />
-                <Parameter id="KCO3unu7SUKe1g14iTqfFQ" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.05" />
-                <Parameter id="TJI_KMfBwEWU3E4zZ64T1w" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="4.5E-08" displayUnit="µm" />
-                <Parameter id="Uhlt0Lxt9EWnQm-4hpxOvA" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" visible="1" canBeVaried="1" value="1.43333333333333E-11" displayUnit="ml/min/N" />
-                <Parameter id="Ys6-IVt0hUae0hEjj4IsCw" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.1" />
-                <Parameter id="tVEF8idc70aTd8MQTUpxVw" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0115" />
-                <Parameter id="U0ERYz56AUWJADVQY4uj4A" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.14" />
-                <Parameter id="j8T_mCZj0UupW2JZZDhDZw" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.168" />
-                <Parameter id="PQ3k1P9DEUCKRaCcFqRxpg" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0166" />
-                <Parameter id="q18ZYhiw0kOgn95nW4PtPQ" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.157" />
-                <Parameter id="CSrTYofoHUuFnbf6crVlzw" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-                <Parameter id="mlaYnQgaL0if1te8s0cXsQ" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.16" />
-                <Parameter id="KyisRonVAEODtC7yY99yuw" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.731" />
-                <Parameter id="OwRVcRYB0EagKd3CpKLH5A" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.758" />
-                <Parameter id="NF4PRAbzZkO3I7F6DWO7eg" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.1" />
-                <Parameter id="FdSRZQUWjkOJeMsQ1C0F0g" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0135" />
-                <Parameter id="kk7rWFKxVEenOSZ9gVtS5A" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0528" />
-                <Parameter id="FBSEOlXbi0S3uwKZrIvcpA" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0473" />
-                <Parameter id="jSyQ7Hw0EkyY108e_4s-Qw" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0106" />
-                <Parameter id="bEfMNDHupkm22YL3nblQ8Q" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.32" />
-                <Parameter id="AgBvma20zkKCzhtwtAz0Iw" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.19" />
-                <Parameter id="dZy-lSLFqU26q24nWRUHZw" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.248" />
-                <Parameter id="MIzE6qXT4k6Gj2SojNMd2A" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.7" />
-                <Parameter id="hMAgi-EtZkuVLJXIOHZ_qQ" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0099" />
-                <Parameter id="aM8h7FCJrke1tK2420oJJg" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="2.25" />
-                <DistributedParameter id="w_jQ1Zb6L0eBwnkoQUHlvA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="19bmYtinX0iphVaTkyR4eg" mode="Logical" visible="1" displayUnit="l">
-                  <Children>
-                    <Parameter id="TMfBSgiVx0O6vcstDyWz-w" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.501686042726849" displayUnit="l" />
-                    <Parameter id="CbThZQfXoEqXIAEPfHilNg" name="Mean" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" value="0.33610750955904" displayUnit="l" />
-                    <Parameter id="vUnttr-4XEuGIFx9LYN--w" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0644491961210393" displayUnit="l" />
-                  </Children>
-                </DistributedParameter>
-                <DistributedParameter id="9CQU3DGQBkCTVNd5XXs3FQ" name="Specific blood flow rate" description="Blood flow rate normalized to the organ volume" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" formula="k_YZJk-8HE-Q5Eb1M2MhwA" mode="Logical" visible="1" displayUnit="ml/min/100g organ">
-                  <Children>
-                    <Parameter id="usBP-FBmVES6PrwrgZrcCg" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" displayUnit="ml/min/100g organ" />
-                    <Parameter id="Muq9h0oHLESIl1b4ot7saA" name="Mean" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" visible="0" canBeVaried="1" value="0.62335" displayUnit="ml/min/100g organ" />
-                    <Parameter id="1sXbOEVJfUyoeRuMVSIB3w" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0311675" displayUnit="ml/min/100g organ" />
-                  </Children>
-                </DistributedParameter>
-                <Container id="8FF9S5dtNES_fI7J-tqAmQ" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Heart" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="nWe_73oazkyBZNA4iCXDCw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="gFiZq_J13EaghZPBBTnkmw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Container id="dkPR59sf20yp5WyhUuO_Jw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Children>
-                        <Parameter id="yD9U10Hy8kG3U4_GzIipDA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" visible="0" canBeVaried="0" />
-                        <Parameter id="A8TYXwGNt0qxYiSUThbXeQ" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="2ChqB3XlJECSWoT4xWUL4g" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Heart" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="eFBM8DdCSEKjQv_nPZRi6Q" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="H94p5wqHxkiiv3O9GoZqGg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Container id="NS74tVcs90yET24H4AUgQA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Children>
-                        <Parameter id="PEyufYamnUK-Ci6IQeBAbQ" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                        <Parameter id="LHgkgxyqyU22ypBP8rRu6w" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" visible="0" canBeVaried="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="_MdcEmv4h0Gvl-1SRpASXg" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Heart" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="Ei40ijCK_E2wZ1kkKQy7ug" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="p7x6oV3ARE-fE64aD8Pz2w" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Parameter id="X7rXFWnKmUa9XZcdPLyS2A" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_pH_INT" visible="1" canBeVaried="1" />
-                    <Container id="5XSOJSl-6UqHOD-qvW0DSg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Children>
-                        <Parameter id="hdJP9cv-lUGHk4f5IToQmA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                        <Parameter id="M5XUJiglb0KV3eUFYyQwGA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_hrt" visible="0" canBeVaried="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="VCB9eB3pKUCP3lOkO16geQ" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Heart" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="7WSl51LXpEaWEObqq3yvjw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="gRifxgXMHkunDWx9T1trTQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Parameter id="zaFszGwVV02ma0FjiNXIRg" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.1" />
-                    <Container id="oEtllhPT60uj2Sp5s8VHBQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Children>
-                        <Parameter id="UOD-Q6VQukWN2aY5dGamow" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_hrt" visible="0" canBeVaried="0" />
-                        <Parameter id="fGvA4FHwik22VaTAHkUjRA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-              </Children>
-            </Container>
-            <Container id="ytN9kAppAUqGM87pofblMA" name="Kidney" description="Kidney" icon="Kidney" mode="Logical" containerType="Organ">
-              <Tags>
-                <Tag value="TissueOrgan" />
-              </Tags>
-              <Children>
-                <Parameter id="Tl_ax_mw6kmsLmljWQ8b5Q" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="Individual_PKSim.PARAM_Tissue_Weight" visible="0" canBeVaried="1" displayUnit="kg" />
-                <Parameter id="_sPWZsYu4EyCQ9hjDK8v1w" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="VascularEndoVolume.VOLUME_VascularEndo_kid" visible="1" canBeVaried="0" displayUnit="l" />
-                <Parameter id="cnGm8MiTc0ODGlADMNe6HQ" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Lymph_flow_rate_Kidney" visible="1" canBeVaried="1" displayUnit="l/min" />
-                <Parameter id="QFaxidVv_keS10IsgRQErA" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate_Kidney" visible="1" canBeVaried="1" displayUnit="l/min" />
-                <Parameter id="3HGCUnzBpUCjk9MgvmRqcQ" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_f_cell" visible="1" canBeVaried="1" />
-                <Parameter id="X-Cv2ERGq0qERwcvRQurWw" name="GFR (specific)" description="Glomerular filtration rate normalized to the volume of the kidney" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" formula="GFR_Calculation.PARAM_GFR_Spec" visible="1" canBeVaried="1" displayUnit="ml/min/100g organ" />
-                <Parameter id="IL9HhGpfBEKQH_maRhWMaQ" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Q_from_Qspec" visible="1" canBeVaried="1" displayUnit="l/min" />
-                <Parameter id="GLgsGB0vEE-u06TzJ40RFg" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                <Parameter id="-wFw7EJLzk-xYcVmGmQflw" name="Volume (standard kidney)" description="Volume (standard kidney)" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="0" value="0.44" displayUnit="l" />
-                <Parameter id="Ye1DsP0xV0qV7uPbWoKx6g" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.75" />
-                <Parameter id="gwh8M8WUeUKaJufZcLTNiw" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                <Parameter id="ZTOYs3HXgk-kcVhbf22dbw" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="4.5E-08" displayUnit="µm" />
-                <Parameter id="cUA1zwlldki0T8pED7R4eQ" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="2.5E-07" displayUnit="µm" />
-                <Parameter id="6Xyv5rEooEOAkDAzevNCaQ" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" visible="1" canBeVaried="1" value="1.53888888888889E-10" displayUnit="ml/min/N" />
-                <Parameter id="mTaGa7gV6U-Eng1B3G_Yfw" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.05" />
-                <Parameter id="aJ5HIkEp80GiNyDViNMHdg" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0207" />
-                <Parameter id="NJ9I7y7yg0mlt_XiYEkG-g" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.052" />
-                <Parameter id="LTKFl6QatkCncwAXNwnCnw" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.23" />
-                <Parameter id="N4x35veaz06LHNFmyt_4iA" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.171" />
-                <Parameter id="WIXXvbwkwkqYjkS_bkc6eQ" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0162" />
-                <Parameter id="b0WbXOYcYEmZ0FvZcrOneA" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.783" />
-                <Parameter id="GrJESd5sfkSxywJWEIefWw" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-                <Parameter id="lJyDkGwWDE6GjXw90oOmSg" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.774" />
-                <Parameter id="ZvHNszF1WUuSrFuqWp4KRw" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.13" />
-                <Parameter id="_RVglwm-Z0K1V7sJ7pyP9A" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.137" />
-                <Parameter id="rCUhz2RIBkivpqtIKHR0zw" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.2" />
-                <Parameter id="qiwdDnM7g0aSr5g5mlzqPw" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0156" />
-                <Parameter id="s1Kc0rwZ3EKBcKBSE09GEg" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0121" />
-                <Parameter id="Xe0d-BcqbE6TYxHembz8-Q" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0366" />
-                <Parameter id="futade0310-VafA03sQOpw" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.024" />
-                <Parameter id="VuCDavhoxEmvFkO6KmKA_g" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.273" />
-                <Parameter id="la9KegyivESBoJJ_tBRNQg" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.21" />
-                <Parameter id="G0insR5CKEq5iBVj33sW1Q" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.73" />
-                <Parameter id="TZxChkl35UOiNmLisSJLNQ" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.399" />
-                <Parameter id="iUu5UFbM7EG_WutpxADzzQ" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0078" />
-                <Parameter id="UxF-Ipl6-0y7l1E4kc0oqA" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="5.03" />
-                <Parameter id="z5AG60T-UUq_RtP5AmlSVA" name="fGFRpremat" description="Fractional offset in the GFR that corrects for a tendency to slightly underestimate the observed median GFR values in preterm infants below approximately 32 weeks of gestation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.258" />
-                <DistributedParameter id="hN-jpvBTh06eXTcTFCmwmA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="fBEvJgpNZ0GYRslIyWtAAA" mode="Logical" visible="1" displayUnit="l">
-                  <Children>
-                    <Parameter id="CIlfq98DqkqEvBKkyQVJYA" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.502916506718822" displayUnit="l" />
-                    <Parameter id="zvvlPHAohU6wNCAUbvCDvA" name="Mean" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" value="0.352639181853312" displayUnit="l" />
-                    <Parameter id="fMoHQpsYRkKwY6V_ejnP9g" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0868498798527259" displayUnit="l" />
-                  </Children>
-                </DistributedParameter>
-                <DistributedParameter id="Q1XoezWxwkG99mJh86K2ww" name="Hill coefficient for GFR" description="Parameter describing the cooperativity of the process for GFR calculation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="oRqHr5jx4kGpzABvFcijSg" mode="Logical" visible="0">
-                  <Children>
-                    <Parameter id="fZENHpX3vEi7axJuTgi76A" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                    <Parameter id="G8nEdzKk7EyPQyIzwOrbgQ" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="15" />
-                    <Parameter id="c4C5c6v3yES7vRi4oPvZUA" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.257" />
-                  </Children>
-                </DistributedParameter>
-                <DistributedParameter id="Swmya6EP1k-N69P2wr2-Xw" name="TM50 for GFR" description="TM50 for GFR calculation" persistable="0" isFixedValue="0" dim="Age in weeks" quantityType="Parameter" formula="ELN3QXxCCkGbWtB1Jvuu8Q" mode="Logical" visible="0" displayUnit="week(s)">
-                  <Children>
-                    <Parameter id="LT1FNfuiAkay-hFHJ7vWEQ" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" displayUnit="week(s)" />
-                    <Parameter id="KsNP1z7GvU6-k519wUa4Yg" name="Mean" persistable="0" isFixedValue="0" dim="Age in weeks" quantityType="Parameter" visible="0" canBeVaried="1" value="44.4" displayUnit="week(s)" />
-                    <Parameter id="pJerQAMZ10G0eMOz-x7shA" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" dim="Age in weeks" quantityType="Parameter" visible="0" canBeVaried="1" value="1.04" displayUnit="week(s)" />
-                  </Children>
-                </DistributedParameter>
-                <DistributedParameter id="byoqDbjfhUeTUNebTIzAGg" name="GFRmat" description="Mature value for GFR in a healthy adult individual weighing 70 kg (=117 mL/min)" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="5VZNzNq190WpqRwRg5j12A" mode="Logical" visible="0" displayUnit="l/min">
-                  <Children>
-                    <Parameter id="8zk8XdngRkeyBZntEnd0Jw" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" displayUnit="l/min" />
-                    <Parameter id="NqJ4JL7VUUSnqNvbK1Jsxg" name="Mean" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" visible="0" canBeVaried="1" value="0.11704" displayUnit="l/min" />
-                    <Parameter id="pSAnPgNZ9kGSpf7sQPOx3w" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" visible="0" canBeVaried="1" value="0.026708" displayUnit="l/min" />
-                  </Children>
-                </DistributedParameter>
-                <DistributedParameter id="mvGr-5lkg0iPBwy5-5lZeg" name="Specific blood flow rate" description="Blood flow rate normalized to the organ volume" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" formula="QcrwWoSaP0GXOciuA8GiHA" mode="Logical" visible="1" displayUnit="ml/min/100g organ">
-                  <Children>
-                    <Parameter id="0Ebxf5IdmkSsWf9i3q7R7Q" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" displayUnit="ml/min/100g organ" />
-                    <Parameter id="ruUm14-kaUeuSGok_yI53Q" name="Mean" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" visible="0" canBeVaried="1" value="3.02705" displayUnit="ml/min/100g organ" />
-                    <Parameter id="kbVPI-Bm30yDcRTbzbrCBQ" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" visible="0" canBeVaried="1" value="0.1513525" displayUnit="ml/min/100g organ" />
-                  </Children>
-                </DistributedParameter>
-                <Container id="vNliK8ccZ0mhuF90e6m6Sw" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Kidney" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="j2_jmKP7ukG093V89b89kQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="DKqvkmUX4EKRxf0aQ5C2Zg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Container id="s3BN8eKvlU-HfhAinsNOLQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Children>
-                        <Parameter id="oe0EqhyQ102KgPm5QfvFwg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" visible="0" canBeVaried="0" />
-                        <Parameter id="tYm_X10ea06DPxVny2FUgQ" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="8zPkGeGmU0OEOAd4v6wLwA" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Kidney" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="a3rprXYybkCXsby6VHcJ3A" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="eyYdhtrsJESqM5QbMjQ0cA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Container id="Dem-XTL7ck6eLsQdgqyo6A" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Children>
-                        <Parameter id="GFRluTo7b0WXv9LQmt2jfw" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                        <Parameter id="QxHwR2-2ukSptZz3hZczCw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" visible="0" canBeVaried="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="Lowod1S6EUOQfh9G0nlt1A" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Kidney" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="zsvz8_5zsUafkCUg4QBOHQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="1mhx9dzLl0C1VgRn81GArg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Parameter id="MY7qAdzbrkWrzsbJwl-LXA" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_pH_INT" visible="1" canBeVaried="1" />
-                    <Container id="bfed_QN7OEuyLz_WQ4hlhg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Children>
-                        <Parameter id="b_S-zDbIXUCb7112-hlW0A" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                        <Parameter id="ISEQ8RvHf02M4-0YDxEOsA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_kid" visible="0" canBeVaried="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="eLf8CEl_NUi-dMAposbfrA" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Kidney" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="hZUbH17CakCgMQ8A0Kvodw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="jZrtMc06LEmCWgdZ-2P-dQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Parameter id="oh9L7i5LWE223D7kSZwE7w" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.22" />
-                    <Container id="xHKOT09DOkaMzurNkcqKHw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Children>
-                        <Parameter id="x9C_ASBicUSdYGDHd6L2lQ" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                        <Parameter id="FWYke9HP2kyVfMtFdEnYow" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_kid" visible="0" canBeVaried="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="o6ozB8VQSky3KivzfiFkuQ" name="Urine" description="Urine compartment used to collect the fraction excreted to urine" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Kidney" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="j-6EuUf_3US1St4XlDqbug" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="l" />
-                    <Container id="XQl25cyFq0S5IXyf_70SGg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule" />
-                  </Children>
-                </Container>
-              </Children>
-            </Container>
-            <Container id="BKKVWIH-skG5wgiURVEmaw" name="Lumen" description="Lumen" icon="Lumen" mode="Logical" containerType="Organ">
-              <Children>
-                <Parameter id="nurnUq1xCEOJGiiFzEve_Q" name="OralApplicationsEnabled" description="Enables/disables all transports between mucosa and lumen" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="0" value="1" />
-                <Parameter id="NNwL6zIlbkyLCY2G4EsV4Q" name="Paracellular absorption sink condition" description="Flag for conditions of the environment for paracellular absorption: 1= no sink condition, 0 = sink condition" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="0" value="1" />
-                <Parameter id="MHsKvxWJIkq1nXODVjXTnw" name="Transcellular absorption sink condition" description="Flag for conditions of the environment for transcellular absorption: 1=no sink condition, 0=sink condition" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="0" value="1" />
-                <Container id="UmGxOEHQ7kGDntzb_Y39tw" name="Stomach" description="Stomach" icon="Stomach" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Lumen" />
-                    <Tag value="LumenSegment" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="Cvbo6hNpv0GfA8UZZ7L3gA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_LumenSegment" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Parameter id="6mTeAseROUK9Vbjp486AAg" name="Volume (gut wall)" description="Volume of the gut wall" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="MucosaVolume.PARAM_VolumeGutWall" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Parameter id="qs8hZXZ8skSBHqt0Gg8iOA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="pQDrK1qpRkiAVACSg6AYjA" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Lumen_PKSim.PARAM_pH_from_pH_fasted" visible="0" canBeVaried="0" />
-                    <Parameter id="2IPZFUBQ1UmsQ-8JOwuZlw" name="Secretion of liquid" description="Rate of liquid inflow" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Inflow_Stomach" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="MNjHqAjuh0ezzZRVTEfLwQ" name="Absorption of liquid" description="rate of liquid outflow" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" visible="0" canBeVaried="1" value="0" displayUnit="1/min" />
-                    <Parameter id="5NHr1z-Df0-U6vgU9qTTxw" name="FillLevelFlag" description="Fill Level Flag" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Lumen_PKSim.PARAM_FillLevelFlagFlag" visible="0" canBeVaried="1" />
-                    <Parameter id="n_j8CDHO40OI_VaCdt1EOw" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Lumen_PKSim.PARAM_FillLevel" visible="0" canBeVaried="1" />
-                    <Parameter id="bYWjc5WIUEeeQPdp7AAz_w" name="Geometric surface area" description="Geometric surface area of GI segment" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Area" visible="1" canBeVaried="1" displayUnit="cm²" />
-                    <Parameter id="4YNooxkXGUSoVHDRmdZyRw" name="GET of non-disintegrated moiety" description="The time point at which a solid dosage leaves the stomach and enters the duodenum. Please note that the discrete emptying of a solid dosage form depends on both the physiological properties of the individual and the dosage form." persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" visible="1" canBeVaried="1" value="60" displayUnit="min" />
-                    <Parameter id="FBQXvjW5RESBiBFPNjRZaA" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_InverseGastricEmptyingTime" visible="0" canBeVaried="1" displayUnit="1/min" />
-                    <Parameter id="e_N5EBG6pEyz0OROLhYNeQ" name="Liquid" description="Liquid" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Liquid_StartValue" visible="0" canBeVaried="1" rHSFormula="Lumen_PKSim.LiquidRHS_sto" displayUnit="l" />
-                    <Parameter id="w2Ci4pC2S02wt-tazaVAuw" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Lumen_PKSim.PARAM_LiquidTransferRate_sto" visible="0" canBeVaried="0" displayUnit="l/min" />
-                    <Parameter id="sMWLlW5WI0qFy-fbft6bsQ" name="Inverse rate of inflow of liquid into stomach" description="Inverse rate of inflow of liquid into stomach" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" visible="0" canBeVaried="1" value="15" displayUnit="min" />
-                    <Parameter id="zZ8OFB3pTkK-be2TChveVA" name="pH in fasted state" description="pH in fasted state" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="2" />
-                    <Parameter id="HG_Goh-c40Grjryw7iebWg" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" visible="1" canBeVaried="1" value="0.030169" />
-                    <Parameter id="TWYRCseE2kSxlOnWQ2rRBQ" name="Thickness of gut wall" description="Thickness of Gut Wall" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.022668" displayUnit="cm" />
-                    <Parameter id="dk2Geq_vUUyHsqt-Z3vd4A" name="pH in fed state" description="pH in fed state" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="0" value="5.5" />
-                    <DistributedParameter id="UACvlccEvUykic1CvZXcVw" name="Length" description="Length" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Pp6PIJQC2EO37OPtS-BOcw" mode="Logical" visible="1" displayUnit="cm">
-                      <Children>
-                        <Parameter id="6A5QusCsV06nVSCd6jl8Zg" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" displayUnit="cm" />
-                        <Parameter id="xze1ad3uvk-TasxKL-51HQ" name="Mean" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="2" displayUnit="cm" />
-                      </Children>
-                    </DistributedParameter>
-                    <DistributedParameter id="FsWYLdjcmUSoLx4R7FhDWw" name="GET_beta (Weibull function) variability factor" description="GET_beta (Weibull function) variability factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="cADcyacHNE-qHrJMV4yOYw" mode="Logical" visible="0">
-                      <Children>
-                        <Parameter id="PJadvS-bY0-3gjfgKXco6g" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                        <Parameter id="OlDk2Wy_QkKRfw-aeci0aw" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                        <Parameter id="IJ8kcg5zx02xdfZZ80gwKQ" name="GeometricDeviation" description="Geometric standard deviation of LogNormal distribution" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1.32" />
-                      </Children>
-                    </DistributedParameter>
-                    <DistributedParameter id="KTwPaeMT1kGziedXofLW7Q" name="GET_alpha (Weibull function) variability factor" description="GET_alpha (Weibull function) variability factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="cvVVJ-DLBUuqq0M03H9_iQ" mode="Logical" visible="0">
-                      <Children>
-                        <Parameter id="yu2c_RRY_UCsAQMpDcDiYQ" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                        <Parameter id="FyNFLFUL-EW_SeqB8zA-mQ" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                        <Parameter id="DKnpi0GMGEau4Bk8MKAwCg" name="GeometricDeviation" description="Geometric standard deviation of LogNormal distribution" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1.74" />
-                      </Children>
-                    </DistributedParameter>
-                    <DistributedParameter id="ir-eVEt6kUO565A1QRGrHQ" name="Gastric emptying time" description="The time at which the (1-1/e)th part (approximately 63%) of the applied dose (fasted state) is released from the stomach into the duodenum according to a first order process. Please note that in the case that a meal is co-administered with the drug, the gastric emptying rate is described using a Weibull function. The parameters of the Weibull function and, thus, the gastric emptying time, then depend on the volume and composition of the meal" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" formula="t_Qd6-aFeEGnJIQo3Gi5dA" mode="Logical" visible="1" displayUnit="min">
-                      <Children>
-                        <Parameter id="n4ZRR-6vXkSmQuoKjtjWcQ" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" displayUnit="min" />
-                        <Parameter id="6jzklNgIpUKuwza0vFvnqw" name="Mean" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" visible="0" canBeVaried="1" value="15" displayUnit="min" />
-                        <Parameter id="BYf-8c5qdUSIXzxQyQpBPg" name="GeometricDeviation" description="Geometric standard deviation of LogNormal distribution" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1.6" />
-                      </Children>
-                    </DistributedParameter>
-                    <DistributedParameter id="o_SwgVUTe0uwTJOK_W68ww" name="Distal radius" description="Distal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="2rZ7SctDEEKttv7wH31EPg" mode="Logical" visible="1" displayUnit="cm">
-                      <Children>
-                        <Parameter id="dcXBbhJSG0mnQnnbw7GeIw" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" displayUnit="cm" />
-                        <Parameter id="80HNuU2WckujsNFA7woPMg" name="Mean" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" displayUnit="cm" />
-                      </Children>
-                    </DistributedParameter>
-                    <DistributedParameter id="4w8MBBWV4kaAR_yrobSyJg" name="Proximal radius" description="Proximal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="voSeUkZlR0G3AyLI6vmDrg" mode="Logical" visible="1" displayUnit="cm">
-                      <Children>
-                        <Parameter id="-MwaFzdPI0623wB13-2Hmw" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" displayUnit="cm" />
-                        <Parameter id="mpIQCjMOxkuH0cPaZcZ-WA" name="Mean" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" displayUnit="cm" />
-                      </Children>
-                    </DistributedParameter>
-                    <Container id="WHOsa7aQmkOE0BfmdYlJgg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Children>
-                        <Parameter id="G2pA-3qCTEmKUK29MSh_Lw" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" visible="0" canBeVaried="0" />
-                        <Parameter id="XpfbLGK_HEeneW7iZJTROA" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" visible="0" canBeVaried="0" />
-                        <Parameter id="Psjob4LZ9UuquZCbN3Y1-g" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" visible="0" canBeVaried="0" />
-                        <Parameter id="lVv1uszxhEKhxxUcNRI6VA" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" visible="0" canBeVaried="0" />
-                        <Parameter id="XwtMojYMskaE4PnMWFbjXg" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" visible="0" canBeVaried="0" />
-                        <Parameter id="lNMaPZ2yDUyXSXVIlHAbEA" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" visible="0" canBeVaried="0" />
-                        <Parameter id="m70pXnyKAUqORzmcGpCsjg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="0" value="1" />
-                        <Parameter id="nOimqpHVG0SCXc1wmKNpiw" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal_GI" visible="0" canBeVaried="0" />
-                        <Parameter id="sYO9T9PuHU6HtBzCjq_N-Q" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" visible="0" canBeVaried="0" />
-                        <Parameter id="98JD1kZ5EEGXGuviw2ErpQ" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" visible="0" canBeVaried="0" />
-                        <Parameter id="06YuYdhSiEKnccKq1FSNMQ" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" visible="0" canBeVaried="0" />
-                        <Parameter id="znL6ms28zEW6-cvaf5XMVg" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" visible="0" canBeVaried="0" />
-                        <Parameter id="Utjmv9xp8UOOYeQcxJIaZg" name="Solubility" description="Solubility" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" formula="Lumen_PKSim.PARAM_IntestinalSolubility" visible="1" canBeVaried="1" displayUnit="mg/l" />
-                        <Parameter id="u5gdFgL0DESxWFQjX2Jgfg" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" visible="0" canBeVaried="0" />
-                        <Parameter id="uu3af4gqu0O3mOQfMipn1w" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" visible="0" canBeVaried="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="B2SJL0T_506x1Wlk3TTamQ" name="Duodenum" description="Duodenum" icon="Duodenum" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Lumen" />
-                    <Tag value="LumenSegment" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="gGwWKrsTIkWznYCVGmmpOA" name="Proximal radius" description="Proximal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R1" visible="1" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="3yuBI_gm6EWljdPuOeiVSw" name="Absorption of liquid" description="rate of liquid outflow" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Outflow_Duodenum" visible="0" canBeVaried="1" displayUnit="1/min" />
-                    <Parameter id="4eQ-TYdcNkekrDgT-BkXmA" name="Distal radius" description="Distal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R2" visible="1" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="y01Day4Sw0efEkGypTnvCw" name="FillLevelFlag" description="Fill Level Flag" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Lumen_PKSim.PARAM_FillLevelFlagFlag" visible="0" canBeVaried="1" />
-                    <Parameter id="S2C4SrBPn0iuhYU-LZWLcw" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Lumen_PKSim.PARAM_FillLevel" visible="0" canBeVaried="1" />
-                    <Parameter id="AG4k0d-FkUSeBUUpQ_iq8w" name="Geometric surface area" description="Geometric surface area of GI segment" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Area" visible="1" canBeVaried="1" displayUnit="cm²" />
-                    <Parameter id="yqzuRix_LUmq2oDuRKdGTQ" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_InverseSITT_Factor_Duodenum" visible="0" canBeVaried="1" displayUnit="1/min" />
-                    <Parameter id="_lTvVOwzvkWyF-_uhvuOHw" name="Length" description="Length" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Length" visible="1" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="jTUHOqWm7Ee8IOuTW7911Q" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Lumen_PKSim.PARAM_LiquidTransferRate_duo" visible="0" canBeVaried="0" displayUnit="l/min" />
-                    <Parameter id="x8xyyOY5FkeShn_7AnrD8A" name="Secretion of liquid" description="Rate of liquid inflow" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Inflow_Duodenum" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="7zhuCkHsLE20kvME1EC1vg" name="Thickness of gut wall" description="Thickness of Gut Wall" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Thickness" visible="0" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="YrSns_z06EaG_uuXNunY9A" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_LumenSegment" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Parameter id="n_ZKYUHbTUSPq_zWcYHkRw" name="Volume (gut wall)" description="Volume of the gut wall" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="MucosaVolume_Human.PARAM_VolumeGutWall_Duodenum" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Parameter id="uKjVUmYUSE-abwBJ7K5bvQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="Lk1njDAmoEGEL2FMHepw4g" name="Liquid" description="Liquid" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Liquid_StartValue" visible="0" canBeVaried="1" rHSFormula="Lumen_PKSim.LiquidRHS_duo" displayUnit="l" />
-                    <Parameter id="Yo0B1vASbkaVv4EvbD16sQ" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="6" />
-                    <Parameter id="yta_2qYxa0W65jEhwe-67g" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.30705627" displayUnit="1/cm" />
-                    <Parameter id="Tg2SODf3Y0m8grtHj_ziRQ" name="Microvilli factor" description="Microvilli factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="25" />
-                    <Parameter id="fu84Y-Nl3UWDs20KIP5GpQ" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0186500479" displayUnit="cm" />
-                    <Parameter id="Xk8SbQMaSU6lmvOzZ5AQVw" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.00925874" />
-                    <Parameter id="VR8ujqUYCES1iDo7uQomXw" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0020705161" displayUnit="cm" />
-                    <Parameter id="_8Ga8HbqQ0SdKAwBpki-oA" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.010126747" />
-                    <Parameter id="67jyBH9gA0yyaQeS6bAwVA" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.002264627" displayUnit="cm" />
-                    <Parameter id="kMi9uwT3Lk-AELAnAQKStA" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.129622362" />
-                    <Parameter id="QAiVtGW9NEuSzoyHNJx38w" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0289872252" displayUnit="cm" />
-                    <Parameter id="BQhL-0oGm0u7eFdzN8OGSA" name="Intestinal transit rate" description="Transit rate along intestinal segments" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" visible="0" canBeVaried="1" value="116" displayUnit="1/min" />
-                    <Parameter id="ehq2pkHqWEGdWJLPK6GGXg" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" visible="1" canBeVaried="1" value="0.06" />
-                    <Parameter id="XDMZzcsK0kSLBdxSmz4I0g" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0441002752" displayUnit="cm" />
-                    <DistributedParameter id="-kGNxSyldUmCKe9sGd40kA" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="0cjuJADKOEmX-K-BPkdptA" mode="Logical" visible="1">
-                      <Children>
-                        <Parameter id="yF7HgB6q6ESRocewD3SbcA" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                        <Parameter id="Ynl24TqVHkuVnCYcPwAgvw" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="292.6883" />
-                      </Children>
-                    </DistributedParameter>
-                    <Container id="X4OtaTKYt0aLljha7DKoJA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Children>
-                        <Parameter id="z5loT4jK7kS9mNF5wwBkXw" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" visible="0" canBeVaried="0" rHSFormula="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_duo" value="0" displayUnit="µmol" />
-                        <Parameter id="Ul6fW9yWTUyrExdu12bf9g" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" visible="0" canBeVaried="0" />
-                        <Parameter id="x4TqUoNChUSUA1JYxZlVsg" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal_GI" visible="0" canBeVaried="0" />
-                        <Parameter id="VBHbuoLt6E6V2HCwu3Dpwg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="0" value="1" />
-                        <Parameter id="JiP5HcpEbky5tYB1OU2dJQ" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" visible="0" canBeVaried="0" />
-                        <Parameter id="CiqpLP9M0EmVdpJ1_TGtuw" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" visible="0" canBeVaried="0" />
-                        <Parameter id="cnQ4VCePi0m4vg2KEK4DNw" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" visible="0" canBeVaried="0" />
-                        <Parameter id="knwqSLWbLEylcUOhXtGNeg" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" visible="0" canBeVaried="0" />
-                        <Parameter id="ottopOBZpkqa5GFdnnRh3w" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" visible="0" canBeVaried="0" />
-                        <Parameter id="Idi23ZevGUCEl39Ey0a8Sw" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" visible="0" canBeVaried="0" />
-                        <Parameter id="qmpMhs5sY0qL1hfidyKHTg" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" visible="0" canBeVaried="0" />
-                        <Parameter id="AoQXq0J2xUmjXnZoPXM00Q" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" visible="0" canBeVaried="0" />
-                        <Parameter id="odIkMZVi3ECk3y0FJauKcw" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" visible="0" canBeVaried="0" />
-                        <Parameter id="bWip3s1zMk-K7yUmyUbVpQ" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" visible="0" canBeVaried="0" />
-                        <Parameter id="0CDm6vo590as2NGsuNq8WA" name="Solubility" description="Solubility" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" formula="Lumen_PKSim.PARAM_IntestinalSolubility" visible="1" canBeVaried="1" displayUnit="mg/l" />
-                        <Parameter id="WtBuzi-aoUC6WcBbu8W-dw" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" visible="0" canBeVaried="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="yZg5exSq8EiErExr7X9h7A" name="UpperJejunum" description="Upper Jejunum" icon="UpperJejunum" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Lumen" />
-                    <Tag value="LumenSegment" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="T5bYB70KeU6wJ6BdSfvoPA" name="Geometric surface area" description="Geometric surface area of GI segment" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Area" visible="1" canBeVaried="1" displayUnit="cm²" />
-                    <Parameter id="yE9DOVjA80ycpfyeDrSBgg" name="Length" description="Length" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Length" visible="1" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="9VwQSy5Zz0-mM62o-SEVwg" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Lumen_PKSim.PARAM_LiquidTransferRate_uje" visible="0" canBeVaried="0" displayUnit="l/min" />
-                    <Parameter id="NGUQKYfoBke3A4BCdxKdaw" name="Proximal radius" description="Proximal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R1" visible="1" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="xEF0UOOLVUa9ovoP9JLKqw" name="Secretion of liquid" description="Rate of liquid inflow" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Inflow_UpperJejunum" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="FsJhYcstWkecC_igbC0zhA" name="Thickness of gut wall" description="Thickness of Gut Wall" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Thickness" visible="0" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="hSRUpbCmTk2WKNH7n641qQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_LumenSegment" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Parameter id="AAKjzVabZkSN1JLs8JJn0g" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="5-HLIkU2JUyLQR6cfADKyw" name="Volume (gut wall)" description="Volume of the gut wall" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="MucosaVolume_Human.PARAM_VolumeGutWall_UpperJejunum" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Parameter id="9-Hg9VHGzUCZGa-1VQmwFQ" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_InverseSITT_Factor_UpperJejunum" visible="0" canBeVaried="1" displayUnit="1/min" />
-                    <Parameter id="CulAdCIiuk6UcAQjjXnpMg" name="Liquid" description="Liquid" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Liquid_StartValue" visible="0" canBeVaried="1" rHSFormula="Lumen_PKSim.LiquidRHS_uje" displayUnit="l" />
-                    <Parameter id="XIjoGGIeA0yTQv-NnQ0lLA" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Lumen_PKSim.PARAM_FillLevel" visible="0" canBeVaried="1" />
-                    <Parameter id="cUBCbBlGYEGz1v1SceWDSQ" name="Absorption of liquid" description="rate of liquid outflow" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Outflow_UpperJejunum" visible="0" canBeVaried="1" displayUnit="1/min" />
-                    <Parameter id="-eKSO-ZHb0K63FR7V1lBdw" name="Distal radius" description="Distal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R2" visible="1" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="2yzYHoivak-FA6_j4enL7w" name="FillLevelFlag" description="Fill Level Flag" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Lumen_PKSim.PARAM_FillLevelFlagFlag" visible="0" canBeVaried="1" />
-                    <Parameter id="ljA_ciLvE0GKDnQ27rjdRw" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="6.25" />
-                    <Parameter id="9QPMh6LJBkapwV5pii3plQ" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.30703115" displayUnit="1/cm" />
-                    <Parameter id="LkRFEXXL906UEHklulh2ZQ" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.299751712" />
-                    <Parameter id="LHosWQ6sv0Sq1put01kZ1A" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.00925874" />
-                    <Parameter id="LdsyKuVTfEqymx5feBEQrw" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0020705161" displayUnit="cm" />
-                    <Parameter id="LKT5f_z_hEOmVM2DUTfLFA" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0670329582" displayUnit="cm" />
-                    <Parameter id="ADCLygtpaUOmIYibff2KBw" name="Intestinal transit rate" description="Transit rate along intestinal segments" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" visible="0" canBeVaried="1" value="5.0162" displayUnit="1/min" />
-                    <Parameter id="KvOKDVe_IUic3uz-VslTWQ" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" visible="1" canBeVaried="1" value="0.064841" />
-                    <Parameter id="1QHYhh9CuECudfZz-vLEhA" name="Microvilli factor" description="Microvilli factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="25" />
-                    <Parameter id="HByGY0qtKE2--3HgMsixLg" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0589752766" displayUnit="cm" />
-                    <Parameter id="1eOenf993keqrszcmq5Brg" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.024936327" displayUnit="cm" />
-                    <Parameter id="RB3pzuhyNU6vT5d9q9Hu9Q" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.008680069" />
-                    <Parameter id="0nx5tIszSEy0whMC1J4wzw" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0019411088" displayUnit="cm" />
-                    <DistributedParameter id="gukipSlELEagtC83fAYxnQ" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="QzBJKRP1ZEuZ2TNcCm37DQ" mode="Logical" visible="1">
-                      <Children>
-                        <Parameter id="-kbg0I67wEqzZzv7hUKQog" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                        <Parameter id="srnGX3LHC0aOccBf2IqY7A" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="447.9877" />
-                      </Children>
-                    </DistributedParameter>
-                    <Container id="qMVuO4F6Ak2WHKJXpReg0Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Children>
-                        <Parameter id="J8wIlVorb0mSzCBhLU-ROA" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" visible="0" canBeVaried="0" />
-                        <Parameter id="TLH55EzoaEq7zhCN88oXJg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="0" value="1" />
-                        <Parameter id="A-cDmQeniUCLF-r-_xM62Q" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" visible="0" canBeVaried="0" rHSFormula="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_uje" value="0" displayUnit="µmol" />
-                        <Parameter id="mr7C4X3K606Q92RlPcdRAw" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal_GI" visible="0" canBeVaried="0" />
-                        <Parameter id="Tf5dYik580aifuCjA85F5A" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" visible="0" canBeVaried="0" />
-                        <Parameter id="oudqKCPABkuS69S7iOaYRA" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" visible="0" canBeVaried="0" />
-                        <Parameter id="yG_mQeRGskeW-NSC9Ng3lw" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" visible="0" canBeVaried="0" />
-                        <Parameter id="PaEEHLs4g0a8o6QOfpwfjA" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" visible="0" canBeVaried="0" />
-                        <Parameter id="jm57xiyTN0yC-vb340FCBg" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" visible="0" canBeVaried="0" />
-                        <Parameter id="xiFwQxfJ5UqAPd7UHQP6AQ" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" visible="0" canBeVaried="0" />
-                        <Parameter id="hfLhsUYUu0Gp2kyiCu7j6Q" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" visible="0" canBeVaried="0" />
-                        <Parameter id="mVlwdw_Y4kSAg3-GYC77hQ" name="Solubility" description="Solubility" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" formula="Lumen_PKSim.PARAM_IntestinalSolubility" visible="1" canBeVaried="1" displayUnit="mg/l" />
-                        <Parameter id="OAbVEhIZ9Eakz11i2eB3nw" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" visible="0" canBeVaried="0" />
-                        <Parameter id="NIFwK2kF6kC7C2MZQeoVAg" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" visible="0" canBeVaried="0" />
-                        <Parameter id="PVnbn557MkmZkHuACs-M-w" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" visible="0" canBeVaried="0" />
-                        <Parameter id="U_8wgIrq0E208BS6bedZXA" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" visible="0" canBeVaried="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="ZDiugimqaEynDJbV3Eje2g" name="LowerJejunum" description="Lower Jejunum" icon="LowerJejunum" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Lumen" />
-                    <Tag value="LumenSegment" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="OFoa5aD_40228XEULX-hTQ" name="Volume (gut wall)" description="Volume of the gut wall" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="MucosaVolume_Human.PARAM_VolumeGutWall_LowerJejunum" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Parameter id="nqtyRjS-2U2xngLkGH-WUQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="dxcFo7SeW0WTGEoV_yiI6Q" name="Thickness of gut wall" description="Thickness of Gut Wall" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Thickness" visible="0" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="jQutTThkxk-vTEkXJPiIkA" name="Absorption of liquid" description="rate of liquid outflow" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Outflow_LowerJejunum" visible="0" canBeVaried="1" displayUnit="1/min" />
-                    <Parameter id="PfCHDqpq9EC3EHn2FPKTLQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_LumenSegment" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Parameter id="RLs7CxfO2UylY3GofshWKA" name="Distal radius" description="Distal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R2" visible="1" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="wQqWV_GgE06h9aBKfIQSmQ" name="FillLevelFlag" description="Fill Level Flag" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Lumen_PKSim.PARAM_FillLevelFlagFlag" visible="0" canBeVaried="1" />
-                    <Parameter id="125YCFyic06B9q7Jtqhqug" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Lumen_PKSim.PARAM_FillLevel" visible="0" canBeVaried="1" />
-                    <Parameter id="sPjzaT4tikGHHjxO2jWOWg" name="Geometric surface area" description="Geometric surface area of GI segment" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Area" visible="1" canBeVaried="1" displayUnit="cm²" />
-                    <Parameter id="2H9_eQj6vkSxGOk7Jde3Zg" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_InverseSITT_Factor_LowerJejunum" visible="0" canBeVaried="1" displayUnit="1/min" />
-                    <Parameter id="OLvGIXjDdk6brHPACp6UqA" name="Length" description="Length" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Length" visible="1" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="RyxV_ab0rE-XObwq2D9TjQ" name="Liquid" description="Liquid" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Liquid_StartValue" visible="0" canBeVaried="1" rHSFormula="Lumen_PKSim.LiquidRHS_lje" displayUnit="l" />
-                    <Parameter id="1zkjIeF5vkCPGTS3NzPodA" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Lumen_PKSim.PARAM_LiquidTransferRate_lje" visible="0" canBeVaried="0" displayUnit="l/min" />
-                    <Parameter id="rSqi80OIH0-LbFWm2OF2Ow" name="Proximal radius" description="Proximal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R1" visible="1" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="9fzsgzickEutFruWnJM64w" name="Secretion of liquid" description="Rate of liquid inflow" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Inflow_LowerJejunum" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="PMcp7mVDUkWegDxI_5oGtw" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0019411088" displayUnit="cm" />
-                    <Parameter id="v07JKkTuU0Cv8ha_92Ff1w" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.30703115" displayUnit="1/cm" />
-                    <Parameter id="UTdwhJPP20K8vRDzW6YThA" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0465856499" displayUnit="cm" />
-                    <Parameter id="IkstwV7dmEiL2ZucnQEzNg" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.008101398" />
-                    <Parameter id="oeNAb3O-qUGd-mskymAisg" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0018117016" displayUnit="cm" />
-                    <Parameter id="5HlXshn3cEmW8KUCUxvrUg" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.008680069" />
-                    <Parameter id="sC8nRFcwSUqbJpijRy0whA" name="Microvilli factor" description="Microvilli factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="25" />
-                    <Parameter id="YYPOm7JsI0OLkKLNpF-66A" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.299751712" />
-                    <Parameter id="ROO6iKx-qEeNHYeyWb71Rg" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0670329582" displayUnit="cm" />
-                    <Parameter id="c-34kapTgEONZQIUATATgw" name="Intestinal transit rate" description="Transit rate along intestinal segments" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" visible="0" canBeVaried="1" value="5.0162" displayUnit="1/min" />
-                    <Parameter id="priInc0sMUGJjAq-NUyfQQ" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" visible="1" canBeVaried="1" value="0.064841" />
-                    <Parameter id="QLAdUtpuVEafIWVrnX08jA" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0196976609" displayUnit="cm" />
-                    <Parameter id="pwDmJwg9HE6PvzyUH2RD8w" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="6.9167" />
-                    <DistributedParameter id="HmpKiYoBhkCijXe-sgUDSA" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="JD5uPYgG2UiM4klfDuppCQ" mode="Logical" visible="1">
-                      <Children>
-                        <Parameter id="PHYEL-hu8ESo6ilxErKYpA" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                        <Parameter id="jTvqTcUomUiH0tFrdoLEWg" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="372.9358" />
-                      </Children>
-                    </DistributedParameter>
-                    <Container id="yvo9YiRhT06MKd7qa37jDg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Children>
-                        <Parameter id="flRLq76gO0awtUvMUXYjBw" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" visible="0" canBeVaried="0" />
-                        <Parameter id="oYkbY1Nkc0CHym-47rwDXQ" name="Solubility" description="Solubility" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" formula="Lumen_PKSim.PARAM_IntestinalSolubility" visible="1" canBeVaried="1" displayUnit="mg/l" />
-                        <Parameter id="p-NiEKI7BU-jLZXS7WNbFw" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" visible="0" canBeVaried="0" />
-                        <Parameter id="6Y5rwJ_hRkq7XHTHs_zM1g" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" visible="0" canBeVaried="0" />
-                        <Parameter id="sCFOUwtO5kCbHskLK4IyWA" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" visible="0" canBeVaried="0" rHSFormula="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_lje" value="0" displayUnit="µmol" />
-                        <Parameter id="3-j48bQykkOeqwwVfano4A" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" visible="0" canBeVaried="0" />
-                        <Parameter id="fTAfL4kZs02idapnirSZgw" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal_GI" visible="0" canBeVaried="0" />
-                        <Parameter id="M8WCc5WLA06VrObr_s4N8A" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" visible="0" canBeVaried="0" />
-                        <Parameter id="34JXEtEGU0KAOZYmw4oXAQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="0" value="1" />
-                        <Parameter id="5YuYZtVHD0qguLi4LhZDkQ" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" visible="0" canBeVaried="0" />
-                        <Parameter id="xHu95_X8Gke4RKtGjNQeHA" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" visible="0" canBeVaried="0" />
-                        <Parameter id="3eVzLIlkrEyghjwVfSL7xQ" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" visible="0" canBeVaried="0" />
-                        <Parameter id="B3Fd7Jz1F02E0FeyJf9uSw" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" visible="0" canBeVaried="0" />
-                        <Parameter id="s87_OQzd60udIyJhMyj__Q" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" visible="0" canBeVaried="0" />
-                        <Parameter id="dvnySQP3RUWgyO6mZ3gBLw" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" visible="0" canBeVaried="0" />
-                        <Parameter id="Lgz85w_PY0SqhjPtFG9ZYA" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" visible="0" canBeVaried="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="GllsaRsHZUOo1T5JiPknaA" name="UpperIleum" description="Upper Ileum" icon="UpperIleum" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Lumen" />
-                    <Tag value="LumenSegment" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="a2GkNcncI0uClPkcp9wi9g" name="Secretion of liquid" description="Rate of liquid inflow" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Inflow_UpperIleum" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="6dvYzwIzg0-vOCHJh5awLg" name="Absorption of liquid" description="rate of liquid outflow" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Outflow_UpperIleum" visible="0" canBeVaried="1" displayUnit="1/min" />
-                    <Parameter id="r5uvYm5FD0qKe0qLIZhFMQ" name="Distal radius" description="Distal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R2" visible="1" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="FbD00tButke226lfbISojQ" name="FillLevelFlag" description="Fill Level Flag" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Lumen_PKSim.PARAM_FillLevelFlagFlag" visible="0" canBeVaried="1" />
-                    <Parameter id="kqr094hHBEWBRl_w2neHrw" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Lumen_PKSim.PARAM_FillLevel" visible="0" canBeVaried="1" />
-                    <Parameter id="Ot3UAXZl_kCi7LQm7m2RkA" name="Geometric surface area" description="Geometric surface area of GI segment" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Area" visible="1" canBeVaried="1" displayUnit="cm²" />
-                    <Parameter id="JwFtlDNxskS2wzEYuyzW_w" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_InverseSITT_Factor_UpperIleum" visible="0" canBeVaried="1" displayUnit="1/min" />
-                    <Parameter id="xbTz_XvhGkOyZL1W581AFg" name="Length" description="Length" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Length" visible="1" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="nURZpPRMA0688szNr4JV9A" name="Liquid" description="Liquid" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Liquid_StartValue" visible="0" canBeVaried="1" rHSFormula="Lumen_PKSim.LiquidRHS_uil" displayUnit="l" />
-                    <Parameter id="1OFo5J_zQ0-lure2SsLN0g" name="Proximal radius" description="Proximal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R1" visible="1" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="uxbgek4ZWkag3I95HLGiAg" name="Thickness of gut wall" description="Thickness of Gut Wall" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Thickness" visible="0" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="T8u6Msrao0-fxn173ixELw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_LumenSegment" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Parameter id="Nz5PfRQOfUyge-Sq05wvbA" name="Volume (gut wall)" description="Volume of the gut wall" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="MucosaVolume_Human.PARAM_VolumeGutWall_UpperIleum" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Parameter id="DBa4pECdvEeFPImPwOtoFg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="heYfR5Ib0ECmzvhVgLLcKg" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Lumen_PKSim.PARAM_LiquidTransferRate_uil" visible="0" canBeVaried="0" displayUnit="l/min" />
-                    <Parameter id="_3x24lQ0pEiZfGLf-yU2Xw" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.30703115" displayUnit="1/cm" />
-                    <Parameter id="O8axTuoRbEq65qdemtuykA" name="Intestinal transit rate" description="Transit rate along intestinal segments" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" visible="0" canBeVaried="1" value="3.3745" displayUnit="1/min" />
-                    <Parameter id="ufCgdSXvY0aY-QgEPEO4rw" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.061552122" displayUnit="cm" />
-                    <Parameter id="KRKEhGIFEUSjBc0REuMEpQ" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0260258863" displayUnit="cm" />
-                    <Parameter id="KRYW-sdNaUO_LLcix7SEdA" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.006944055" />
-                    <Parameter id="01k7e2dJUUC9VvqvZ4tQDw" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0015528871" displayUnit="cm" />
-                    <Parameter id="brKX7CwscUONLtgzpTWdPA" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.008101398" />
-                    <Parameter id="OUqOZdMzKUaDFWJKngTg1A" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0018117016" displayUnit="cm" />
-                    <Parameter id="MXZ1RzeZ6kiDrZY6GRpz1w" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" visible="1" canBeVaried="1" value="0.064841" />
-                    <Parameter id="9izDkSXXOk-JhlBoS4U4gA" name="Microvilli factor" description="Microvilli factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="25" />
-                    <Parameter id="aMg0nnPITESuOKXjyjxOeA" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.445576869" />
-                    <Parameter id="sqkRxSSFIUSC3ucyjY3vOA" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0996435866" displayUnit="cm" />
-                    <Parameter id="UrIIX7xNzEC7qwos_PLdbA" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.2083" />
-                    <DistributedParameter id="yziPD3dZdUG9zp_eWgrkjQ" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="OavS00jhT0Kl8BGNMnfCKw" mode="Logical" visible="1">
-                      <Children>
-                        <Parameter id="QgoNlEIinUWmxRijRR7ESA" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                        <Parameter id="wlWpB2MUJEKYAfdwnwWFPw" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="260.7527" />
-                      </Children>
-                    </DistributedParameter>
-                    <Container id="3MOdew-CBEaM4lPiqh9MxA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Children>
-                        <Parameter id="FcFUy2uQRUKkI_zMY33hHA" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" visible="0" canBeVaried="0" />
-                        <Parameter id="ppEcAqGLZESFruKGPf4nHA" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" visible="0" canBeVaried="0" />
-                        <Parameter id="2A9pheTZr0ups1Rg8g3m_w" name="Solubility" description="Solubility" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" formula="Lumen_PKSim.PARAM_IntestinalSolubility" visible="1" canBeVaried="1" displayUnit="mg/l" />
-                        <Parameter id="0sp06veY80GDVIydsibJ8Q" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" visible="0" canBeVaried="0" />
-                        <Parameter id="V6gypJn6EkaIJOVR51iAJA" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" visible="0" canBeVaried="0" />
-                        <Parameter id="jd19NRLHOUy0EsXXg1HcTw" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" visible="0" canBeVaried="0" />
-                        <Parameter id="tcC0_J8fNkqQfjn3yiNteg" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" visible="0" canBeVaried="0" />
-                        <Parameter id="E_bZ1XAfPE-Igzqydo5jPg" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" visible="0" canBeVaried="0" />
-                        <Parameter id="yr7FNK13KkuOwPo3CMN83A" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" visible="0" canBeVaried="0" />
-                        <Parameter id="tSVLjgG-bEO4T90XDJ5iYQ" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" visible="0" canBeVaried="0" />
-                        <Parameter id="H9D3W4AWNUOk4M00wzclPQ" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" visible="0" canBeVaried="0" />
-                        <Parameter id="54Sd20Ae1kKX_D5MFkJVGA" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" visible="0" canBeVaried="0" />
-                        <Parameter id="TDCVJ28zkUSyJd7Ef9Qjug" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="0" value="1" />
-                        <Parameter id="5A3YGE5rMkC60M6Qwkr9nw" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" visible="0" canBeVaried="0" rHSFormula="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_uil" value="0" displayUnit="µmol" />
-                        <Parameter id="4LtbQNBuREa2BvN95bzbzA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal_GI" visible="0" canBeVaried="0" />
-                        <Parameter id="bRDodopx5U29pZr52bTXoA" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" visible="0" canBeVaried="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="vCPS2yMfPkKIhDcs0uJgFQ" name="LowerIleum" description="Lower Ileum" icon="LowerIleum" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Lumen" />
-                    <Tag value="LumenSegment" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="kh_SpEgOPU2lFUL9oPynIQ" name="Geometric surface area" description="Geometric surface area of GI segment" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Area" visible="1" canBeVaried="1" displayUnit="cm²" />
-                    <Parameter id="d9MFJhOsg0Ce4C7vNlXjcA" name="Absorption of liquid" description="rate of liquid outflow" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Outflow_LowerIleum" visible="0" canBeVaried="1" displayUnit="1/min" />
-                    <Parameter id="IdgoOrOvNEKdJm43M34SlQ" name="Distal radius" description="Distal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R2" visible="1" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="-CtgLW47XkafAda0Ybg43Q" name="FillLevelFlag" description="Fill Level Flag" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Lumen_PKSim.PARAM_FillLevelFlagFlag" visible="0" canBeVaried="1" />
-                    <Parameter id="o7XPEnffckWArz2FHcR1sQ" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_InverseSITT_Factor_LowerIleum" visible="0" canBeVaried="1" displayUnit="1/min" />
-                    <Parameter id="Wt8EXGk7Ik2zGdDjA7BORw" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Lumen_PKSim.PARAM_FillLevel" visible="0" canBeVaried="1" />
-                    <Parameter id="Sb3ST7J1TE2Cu5uwwwHNDQ" name="Length" description="Length" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Length" visible="1" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="t8S7j8o2T0ayEf0H0ctezg" name="Liquid" description="Liquid" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Liquid_StartValue" visible="0" canBeVaried="1" rHSFormula="Lumen_PKSim.LiquidRHS_lil" displayUnit="l" />
-                    <Parameter id="WCIm0RT9ck6eLPM_lxlkZA" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Lumen_PKSim.PARAM_LiquidTransferRate_lil" visible="0" canBeVaried="0" displayUnit="l/min" />
-                    <Parameter id="q-4057jaAkG3crye5Fg6Ig" name="Proximal radius" description="Proximal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R1" visible="1" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="n_coeeB78EuaDFw2a9foKw" name="Secretion of liquid" description="Rate of liquid inflow" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Inflow_LowerIleum" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="q32Tk2eiGk2oKlgyD3h5zA" name="Thickness of gut wall" description="Thickness of Gut Wall" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Thickness" visible="0" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="gwrqDsAN2UGmJg9L2RpqGg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_LumenSegment" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Parameter id="vWH2p75TaUm4Kn2YGK39BQ" name="Volume (gut wall)" description="Volume of the gut wall" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="MucosaVolume_Human.PARAM_VolumeGutWall_LowerIleum" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Parameter id="1KofRpDdX0iSaXCFGTw98A" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="7391ZxxWsEKf-lwfSasvcA" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" visible="1" canBeVaried="1" value="0.064841" />
-                    <Parameter id="_vdSUClFakSHPvEtvgMeew" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0015528871" displayUnit="cm" />
-                    <Parameter id="QS0Mc7es3EO7PHc-AoKOtw" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.30705627" displayUnit="1/cm" />
-                    <Parameter id="k7-DVmpu30ydy0S0RRJVVw" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0350288649" displayUnit="cm" />
-                    <Parameter id="wzUr9VsB1Um8uHq-Tl3eNQ" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0148137399" displayUnit="cm" />
-                    <Parameter id="ZVOpwcAx30C4MRWFc-UtLA" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.005786713" />
-                    <Parameter id="3hhntomVcUyFkXhaAWTnNQ" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0012940725" displayUnit="cm" />
-                    <Parameter id="VXwrVdQwMkKbUWxMGGsECQ" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.006944055" />
-                    <Parameter id="9aYz3sdKq0etEhILsx9fAQ" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.4583" />
-                    <Parameter id="GhOhCtx4aEebDd4x1Q4EmQ" name="Microvilli factor" description="Microvilli factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="25" />
-                    <Parameter id="Cxhqh5BBJEGFBUWeitJ2Ow" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.445576869" />
-                    <Parameter id="ucucMhx4fUKcOkI_kczYuw" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0996435866" displayUnit="cm" />
-                    <Parameter id="oQMtdadgd06eMuiZUJJ5Xw" name="Intestinal transit rate" description="Transit rate along intestinal segments" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" visible="0" canBeVaried="1" value="3.3745" displayUnit="1/min" />
-                    <DistributedParameter id="Dd2maW0N60-iE8yAtMML8A" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="u8GosNQmv0iy2QPr7LMEOw" mode="Logical" visible="1">
-                      <Children>
-                        <Parameter id="0vSMHrWhm0uQMdnyW0k9vA" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                        <Parameter id="Pa2MUluggEan_a-iiC05VQ" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="146.565" />
-                      </Children>
-                    </DistributedParameter>
-                    <Container id="9u38ciR_QU-2yfc7VXCSgA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Children>
-                        <Parameter id="P__C_efOLk6JXPNp_UxjVw" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" visible="0" canBeVaried="0" />
-                        <Parameter id="6zocQFpUyEOCrJOagrza_Q" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal_GI" visible="0" canBeVaried="0" />
-                        <Parameter id="uI2y56-0n0SiJnJY1wgwXQ" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" visible="0" canBeVaried="0" rHSFormula="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_lil" value="0" displayUnit="µmol" />
-                        <Parameter id="PzuuZIcjGUqvPcdjQ7Bb_w" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="0" value="1" />
-                        <Parameter id="WWJsy4ZwYEqjPyXe2sFhCQ" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" visible="0" canBeVaried="0" />
-                        <Parameter id="ZDHedyprv0ucSrG2mX9a1A" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" visible="0" canBeVaried="0" />
-                        <Parameter id="cpOkTGvNIEij8OPooe9kjQ" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" visible="0" canBeVaried="0" />
-                        <Parameter id="mNEtMK2NRkqW8He-Tzc9jw" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" visible="0" canBeVaried="0" />
-                        <Parameter id="li1F0KI0rkq0iyC3Oxls2Q" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" visible="0" canBeVaried="0" />
-                        <Parameter id="zqjXuyo6r0SXIUpHHgZo1g" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" visible="0" canBeVaried="0" />
-                        <Parameter id="v3oqt0qPrUKEmWG8ETR6ew" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" visible="0" canBeVaried="0" />
-                        <Parameter id="gJuuRtVED0SsYNBetGbhBA" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" visible="0" canBeVaried="0" />
-                        <Parameter id="7m0VNFOSdk6JE30EdGvSAg" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" visible="0" canBeVaried="0" />
-                        <Parameter id="QJGzZh_1m0SO94brMFzDXw" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" visible="0" canBeVaried="0" />
-                        <Parameter id="DpnSq5oveEKUMETwLblZsA" name="Solubility" description="Solubility" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" formula="Lumen_PKSim.PARAM_IntestinalSolubility" visible="1" canBeVaried="1" displayUnit="mg/l" />
-                        <Parameter id="zhWaif-DGUenQm8w-BaupA" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" visible="0" canBeVaried="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="sk41NH_8KEi_nNbtDlGvFA" name="Caecum" description="Cecum" icon="Caecum" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Lumen" />
-                    <Tag value="LumenSegment" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="gToiH_HN80SqYdOEPEREhA" name="Volume (gut wall)" description="Volume of the gut wall" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="MucosaVolume_Human.PARAM_VolumeGutWall_Caecum" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Parameter id="Nwi502Vet0G9rjE2Z8kOpQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="E0LVcdWbhk-SLj_buVXJ4A" name="Distal radius" description="Distal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R2" visible="1" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="a6kaYGjzBkq6LhcP8jhvFg" name="Absorption of liquid" description="rate of liquid outflow" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Outflow_Caecum" visible="0" canBeVaried="1" displayUnit="1/min" />
-                    <Parameter id="oYRvfJFekkCTA524j2Wmdg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_LumenSegment" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Parameter id="PRK1FE0Ez0OkWkklE7JIMA" name="FillLevelFlag" description="Fill Level Flag" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Lumen_PKSim.PARAM_FillLevelFlagFlag" visible="0" canBeVaried="1" />
-                    <Parameter id="w2-duxeNX0-ZLM9E3_V2EQ" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Lumen_PKSim.PARAM_FillLevel" visible="0" canBeVaried="1" />
-                    <Parameter id="Pe1yKTL8hkCl2-nKeZJWgg" name="Geometric surface area" description="Geometric surface area of GI segment" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Area" visible="1" canBeVaried="1" displayUnit="cm²" />
-                    <Parameter id="Zr0sYCtn00ixQom3uszg0Q" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_InverseLITT_Factor_Caecum" visible="0" canBeVaried="1" displayUnit="1/min" />
-                    <Parameter id="L-iTq8ijD0KsZusg4tJm2g" name="Length" description="Length" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Length" visible="1" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="6oVrtAPPFUyejLLiKWfAsQ" name="Liquid" description="Liquid" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Liquid_StartValue" visible="0" canBeVaried="1" rHSFormula="Lumen_PKSim.LiquidRHS_cae" displayUnit="l" />
-                    <Parameter id="zuXQZtFQeE6UnViJ1zBxFg" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Lumen_PKSim.PARAM_LiquidTransferRate_cae" visible="0" canBeVaried="0" displayUnit="l/min" />
-                    <Parameter id="gB88liaA00asPJ6srGUy1A" name="Proximal radius" description="Proximal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R1" visible="1" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="amqfKmZaBUmTvZS0d48Gpg" name="Secretion of liquid" description="Rate of liquid inflow" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Inflow_Caecum" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="9ksbuIGfNEG9VLvs6f5BGg" name="Thickness of gut wall" description="Thickness of Gut Wall" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Thickness" visible="0" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="oNCBCC1H70OFgwfzoj5ymA" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0060009" />
-                    <Parameter id="a2eWsugqn0GJCrM7APrhcw" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0446435379" displayUnit="cm" />
-                    <Parameter id="MQYrv1Hsg06YtGXxJF-I7g" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.00877" displayUnit="cm" />
-                    <Parameter id="62dNon1_BE2rTW_APfXJ_Q" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.015672726" />
-                    <Parameter id="AsOiAnu6zE6ej3QE6QI0uQ" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.067256381" displayUnit="cm" />
-                    <Parameter id="_GTgvfKtwUWsFXt9qun_zw" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.015672726" />
-                    <Parameter id="b-o2UQBYlE2zyj8wEGt0JA" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.067256381" displayUnit="cm" />
-                    <Parameter id="7PY0kjH8ZkKCTVpa6Bje3g" name="Microvilli factor" description="Microvilli factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                    <Parameter id="ax74o0HE1U6eK4v5qHuGyg" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.026864843" />
-                    <Parameter id="4P33PXH950iyxBhPfoZipg" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.1152851235" displayUnit="cm" />
-                    <Parameter id="zg3g5pUupU2Mp8Ay3no_zQ" name="Intestinal transit rate" description="Transit rate along intestinal segments" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" visible="0" canBeVaried="1" value="18.3333" displayUnit="1/min" />
-                    <Parameter id="A3e2pt_IcUyEQ3Tj009rsg" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0897885" displayUnit="1/cm" />
-                    <Parameter id="3amM8GpOs0qiotq02w1snA" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="5.7" />
-                    <DistributedParameter id="FgQ-FcIpkU67WGS3N4QX2A" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="oHit47I8Hk6_2opTctJUCA" mode="Logical" visible="1">
-                      <Children>
-                        <Parameter id="TiVG1mvBu06TtlRGZEhjHQ" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                        <Parameter id="z7rb74fSQU-BuaTUIH5-PQ" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1.8" />
-                      </Children>
-                    </DistributedParameter>
-                    <Container id="roHdhepN4U2CuJZxmpRwCQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Children>
-                        <Parameter id="lSEEE17KgUWraEuPJrsW3w" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" visible="0" canBeVaried="0" />
-                        <Parameter id="BE1MKZ_dhEen2DL_7LL5Jg" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal_GI" visible="0" canBeVaried="0" />
-                        <Parameter id="7Q-E9DA2YkG-AAffcg_HqA" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" visible="0" canBeVaried="0" rHSFormula="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_cae" value="0" displayUnit="µmol" />
-                        <Parameter id="j27_hJy1KUuTKAJzADxV_w" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="0" value="1" />
-                        <Parameter id="U2M6KYRtTUGt8spHAyx-SQ" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" visible="0" canBeVaried="0" />
-                        <Parameter id="09DiKApI_kOV2zUicF_XYw" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" visible="0" canBeVaried="0" />
-                        <Parameter id="APlmwYRaeUi8ewW2Ba1D7g" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" visible="0" canBeVaried="0" />
-                        <Parameter id="bTMzOxCfvUyVdIJD4mSh2Q" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" visible="0" canBeVaried="0" />
-                        <Parameter id="y386tFiLzk2HXdmILwKCVw" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" visible="0" canBeVaried="0" />
-                        <Parameter id="miieZ3YFzEW0RMLpLxW6uQ" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" visible="0" canBeVaried="0" />
-                        <Parameter id="Twt-BhI_mkKUuZGs7O9Q4A" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" visible="0" canBeVaried="0" />
-                        <Parameter id="S_WQp0Y9KUCoWi2LOijxww" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" visible="0" canBeVaried="0" />
-                        <Parameter id="wt6RG0zNDkO2pHtvtgsfYw" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" visible="0" canBeVaried="0" />
-                        <Parameter id="FkH71QboOUeOcyhgps1SXg" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" visible="0" canBeVaried="0" />
-                        <Parameter id="92NjfYHQQEKEweDBZqRJmg" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" visible="0" canBeVaried="0" />
-                        <Parameter id="1Szu0BZJQEmY6oRdv1W9CQ" name="Solubility" description="Solubility" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" formula="Lumen_PKSim.PARAM_IntestinalSolubility" visible="1" canBeVaried="1" displayUnit="mg/l" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="xYyLHo4Vhk6D6RJrPpFicA" name="ColonAscendens" description="Colon Ascendens" icon="ColonAscendens" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Lumen" />
-                    <Tag value="LumenSegment" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="KNKeBc2R60-3GQ0n7BwVyw" name="Thickness of gut wall" description="Thickness of Gut Wall" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Thickness" visible="0" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="EuzCfKDd7EmCfDrChQ-JVQ" name="Absorption of liquid" description="rate of liquid outflow" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Outflow_ColonAscendens" visible="0" canBeVaried="1" displayUnit="1/min" />
-                    <Parameter id="mWdp8dv1akibZkNQmj5A9Q" name="Distal radius" description="Distal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R2" visible="1" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="kFsIDEior0OWmlrXCLESyw" name="FillLevelFlag" description="Fill Level Flag" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Lumen_PKSim.PARAM_FillLevelFlagFlag" visible="0" canBeVaried="1" />
-                    <Parameter id="E6LAQzyZVE2N4NQeuDqVvw" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Lumen_PKSim.PARAM_FillLevel" visible="0" canBeVaried="1" />
-                    <Parameter id="cJ8MDXS7002EmoC7UK-psg" name="Geometric surface area" description="Geometric surface area of GI segment" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Area" visible="1" canBeVaried="1" displayUnit="cm²" />
-                    <Parameter id="iJIVliOXnUaOszHEp8KzXA" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_InverseLITT_Factor_ColonAscendens" visible="0" canBeVaried="1" displayUnit="1/min" />
-                    <Parameter id="adzP2OfBuEuwEikUlGS8WQ" name="Length" description="Length" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Length" visible="1" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="DXFEeuQ_90iRWGDwDblaqg" name="Liquid" description="Liquid" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Liquid_StartValue" visible="0" canBeVaried="1" rHSFormula="Lumen_PKSim.LiquidRHS_colasc" displayUnit="l" />
-                    <Parameter id="5mpe7C5hA0edNRzvY-IdTw" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Lumen_PKSim.PARAM_LiquidTransferRate_colasc" visible="0" canBeVaried="0" displayUnit="l/min" />
-                    <Parameter id="I58SkXfflkq41JS7eLtY2w" name="Secretion of liquid" description="Rate of liquid inflow" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Inflow_ColonAscendens" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="yQgFTXWlO0C7lJ6_LOjFag" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_LumenSegment" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Parameter id="LF_e6DoE1UmI0XvfjGzlWQ" name="Volume (gut wall)" description="Volume of the gut wall" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="MucosaVolume_Human.PARAM_VolumeGutWall_ColonAscendens" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Parameter id="0ATLLfFN6kiChcklZhBJpA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="EqhXpioMhUeoWaOSHyUTDw" name="Proximal radius" description="Proximal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R1" visible="1" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="mEK3YoOGnEi3MEyWPm33iQ" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.09106073" displayUnit="1/cm" />
-                    <Parameter id="1OlkgnYAWUuUmCMpXpavUg" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0280138174" displayUnit="cm" />
-                    <Parameter id="RXWnF7meVEW6iaV2KGgzMw" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.00554" displayUnit="cm" />
-                    <Parameter id="uPg1vIzVzESoLyaV23ytnw" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.067256381" displayUnit="cm" />
-                    <Parameter id="-Ig_K2Dym021s9Ws__Q_8w" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.015672726" />
-                    <Parameter id="Uh182ZUWyEujmSKJziQGHQ" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.067256381" displayUnit="cm" />
-                    <Parameter id="S5k4A9rRz0yTiEzJjxWq5Q" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="5.6" />
-                    <Parameter id="QX-OxQgp6kSuti7nPeQQQQ" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.015672726" />
-                    <Parameter id="Ok3w4ly8QUWworTqXjz12g" name="Microvilli factor" description="Microvilli factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                    <Parameter id="vNdK9-fdM0S0Su5yO6bNmQ" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.075727844" />
-                    <Parameter id="bGNo8o9jdkaXHKVgPuf9Cg" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.3117189273" displayUnit="cm" />
-                    <Parameter id="oL4NwHi-DUKi3DZgutwigA" name="Intestinal transit rate" description="Transit rate along intestinal segments" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" visible="0" canBeVaried="1" value="10" displayUnit="1/min" />
-                    <Parameter id="JOKDq9srWEKgVUNRaKg2fA" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0060009" />
-                    <DistributedParameter id="z8ms_CzKeEapBplzPdB-LQ" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="1N7zSPApMkGHQv7WuT_Mcw" mode="Logical" visible="1">
-                      <Children>
-                        <Parameter id="XWdg-UrHpE2EZdLSjvPkFA" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                        <Parameter id="AN7nxhk6dUCpdp7mxWHpqw" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="2.5" />
-                      </Children>
-                    </DistributedParameter>
-                    <Container id="syKwn295jEqfzqiUgKRW7A" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Children>
-                        <Parameter id="-QBcotx1BE-iSr_uI4X0PQ" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal_GI" visible="0" canBeVaried="0" />
-                        <Parameter id="85U3b0kqbUOp5YcEtvpUQw" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" visible="0" canBeVaried="0" />
-                        <Parameter id="R7sLKCsgIEGIeI6KjimRsA" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" visible="0" canBeVaried="0" rHSFormula="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_colasc" value="0" displayUnit="µmol" />
-                        <Parameter id="4CRan7JTN0SPpwaNQz-C8g" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="0" value="1" />
-                        <Parameter id="wrCgjZHXWUyNNXmbRp7kTQ" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" visible="0" canBeVaried="0" />
-                        <Parameter id="kva22Q81zEKiH_H7Uq0ZBw" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" visible="0" canBeVaried="0" />
-                        <Parameter id="m2cTJUZREU2a_zxQYnA13Q" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" visible="0" canBeVaried="0" />
-                        <Parameter id="N7ApCmDjAEKmB98rXQ71og" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" visible="0" canBeVaried="0" />
-                        <Parameter id="zXYc7rSNbUmybovfSCO8Bg" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" visible="0" canBeVaried="0" />
-                        <Parameter id="hegX42EcH0G6JPSrArlkgw" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" visible="0" canBeVaried="0" />
-                        <Parameter id="SPdg8y6xrkqrpLW2Zp-pOg" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" visible="0" canBeVaried="0" />
-                        <Parameter id="4z3VJoqJYUqDGBgI469L8g" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" visible="0" canBeVaried="0" />
-                        <Parameter id="xztWFjE_SUSLoNHwrEOzxg" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" visible="0" canBeVaried="0" />
-                        <Parameter id="_WesX-q9nkS8Ix-M-XSZ7A" name="Solubility" description="Solubility" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" formula="Lumen_PKSim.PARAM_IntestinalSolubility" visible="1" canBeVaried="1" displayUnit="mg/l" />
-                        <Parameter id="JtO4ClpRG0eAFxnwhbaAkA" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" visible="0" canBeVaried="0" />
-                        <Parameter id="awrM0bqmkEq05Pv0_eBjKQ" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" visible="0" canBeVaried="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="EhWe8Xqa6EKqp-YjJgQUiw" name="ColonTransversum" description="Colon Transversum" icon="ColonTransversum" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Lumen" />
-                    <Tag value="LumenSegment" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="H1V9ErgHk0CxUCdYvDh7tg" name="Length" description="Length" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Length" visible="1" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="J0BMS9a5jEumB-XCW-PiJA" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Lumen_PKSim.PARAM_LiquidTransferRate_coltrans" visible="0" canBeVaried="0" displayUnit="l/min" />
-                    <Parameter id="6fBptez7tkKzl8pS_1xBeA" name="Proximal radius" description="Proximal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R1" visible="1" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="msO8PKmq9EiI4hfZMlnybA" name="Secretion of liquid" description="Rate of liquid inflow" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Inflow_ColonTransversum" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="0wwplg8omUOxZjzbqKoPKw" name="Thickness of gut wall" description="Thickness of Gut Wall" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Thickness" visible="0" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="EVfUyOpPEkGVALpa7Uw5JA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_LumenSegment" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Parameter id="_KW7ZbeYGkmMic8h-aaZLQ" name="Volume (gut wall)" description="Volume of the gut wall" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="MucosaVolume_Human.PARAM_VolumeGutWall_ColonTransversum" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Parameter id="QxXdycspKky30i-ze8vqjg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="35fXNzOhWkS6e7uE4Ltj6w" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_InverseLITT_Factor_ColonTransversum" visible="0" canBeVaried="1" displayUnit="1/min" />
-                    <Parameter id="pIWI5VJqdEuZKOM68npr-g" name="Liquid" description="Liquid" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Liquid_StartValue" visible="0" canBeVaried="1" rHSFormula="Lumen_PKSim.LiquidRHS_coltrans" displayUnit="l" />
-                    <Parameter id="S82jSlVXO0i0ThcP2Vqixg" name="Absorption of liquid" description="rate of liquid outflow" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Outflow_ColonTransversum" visible="0" canBeVaried="1" displayUnit="1/min" />
-                    <Parameter id="3KjT-_RqBEuLMrll1J5reg" name="Distal radius" description="Distal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R2" visible="1" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="uTzExOd0hkKms-SUrZsovg" name="FillLevelFlag" description="Fill Level Flag" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Lumen_PKSim.PARAM_FillLevelFlagFlag" visible="0" canBeVaried="1" />
-                    <Parameter id="va44ow3wpEeLEBooAmsWtA" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Lumen_PKSim.PARAM_FillLevel" visible="0" canBeVaried="1" />
-                    <Parameter id="yC2eHcrziEyuDf1hGDTnfg" name="Geometric surface area" description="Geometric surface area of GI segment" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Area" visible="1" canBeVaried="1" displayUnit="cm²" />
-                    <Parameter id="m5RB2ThQvk6kIeooyklBQQ" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0060009" />
-                    <Parameter id="mthB6rl-Z0SqyvT_pq9WgA" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.6886041141" displayUnit="cm" />
-                    <Parameter id="gOHfCof0YUqkKLX7HGRL3w" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0384322177" displayUnit="cm" />
-                    <Parameter id="r-mVWEhvHU29Jf9GAgjFfA" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.08637087" displayUnit="1/cm" />
-                    <Parameter id="2P5U6mPX1kCsPb7JBsfLLA" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0394956146" displayUnit="cm" />
-                    <Parameter id="9SkQLGdrpECJPX_okBMs7g" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0076" displayUnit="cm" />
-                    <Parameter id="FPqS2AV6K0GNMy2GdkD03A" name="Intestinal transit rate" description="Transit rate along intestinal segments" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" visible="0" canBeVaried="1" value="3.3333" displayUnit="1/min" />
-                    <Parameter id="hYlrKgXfJkis8PQLaU8LcQ" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.008955843" />
-                    <Parameter id="dtEGAv56R027GTfetyixlw" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.015672726" />
-                    <Parameter id="4Je0Z2gE_EaNkjCVJtYUeA" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.067256381" displayUnit="cm" />
-                    <Parameter id="vNaHD3EU5EuGu5hHnf9sew" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="5.7" />
-                    <Parameter id="PjEvPQ9eFECFxkLWufAS6w" name="Microvilli factor" description="Microvilli factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                    <Parameter id="uQhev0hgLU2znFjvFmMxhw" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.144607745" />
-                    <DistributedParameter id="_sZIPmV9lkGren6zHhyVKQ" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="D5U85nbrl0KGV9gbw85u9A" mode="Logical" visible="1">
-                      <Children>
-                        <Parameter id="gv-VIaUqakmLAQA25SdcYQ" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                        <Parameter id="ek5Udv6FSEqer6vkHbeAGw" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="2.5" />
-                      </Children>
-                    </DistributedParameter>
-                    <Container id="RkXFSuxegE6TC756FHtn7Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Children>
-                        <Parameter id="KZl-P-RUhkWX2dFG0HWctw" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" visible="0" canBeVaried="0" />
-                        <Parameter id="GbRtjvCmA0iKIepcBZDItA" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" visible="0" canBeVaried="0" />
-                        <Parameter id="J33_qWrWsEartYO66vNfUQ" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" visible="0" canBeVaried="0" />
-                        <Parameter id="c1dcxag-8UOMMHZ5OMdbEw" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" visible="0" canBeVaried="0" />
-                        <Parameter id="5JmTFAq_6UixI7FJ5Yx_Yg" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" visible="0" canBeVaried="0" />
-                        <Parameter id="wCBdXG-G3UWA34D38I0pMw" name="Solubility" description="Solubility" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" formula="Lumen_PKSim.PARAM_IntestinalSolubility" visible="1" canBeVaried="1" displayUnit="mg/l" />
-                        <Parameter id="019zEw9TNE6Ed8u-BJhuVw" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" visible="0" canBeVaried="0" />
-                        <Parameter id="8ecyYQ2RxUiOeZtlhNqYzA" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" visible="0" canBeVaried="0" />
-                        <Parameter id="PmlalUHQ2UGb3FcUGNvTRg" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" visible="0" canBeVaried="0" />
-                        <Parameter id="rnD1qKiD80u_LL2VBapK1g" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" visible="0" canBeVaried="0" />
-                        <Parameter id="ghBNG6T4WUK8Vq35hkZ1bA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal_GI" visible="0" canBeVaried="0" />
-                        <Parameter id="nw1gan1rpEalWI7Ndyju2A" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" visible="0" canBeVaried="0" rHSFormula="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_coltrans" value="0" displayUnit="µmol" />
-                        <Parameter id="P9XC-Dqw8kif-HD8FjjXKw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="0" value="1" />
-                        <Parameter id="SR56aK-GyEWez064RGUcoQ" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" visible="0" canBeVaried="0" />
-                        <Parameter id="_2qzgQJREE-LLir0cNnprw" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" visible="0" canBeVaried="0" />
-                        <Parameter id="Joinae4GTk-OuwWtm21NyQ" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" visible="0" canBeVaried="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="TQQ1m1iJG0CQmvlfvaPkuA" name="ColonDescendens" description="Colon Descendens / Distal Colon 1" icon="ColonDescendens" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Lumen" />
-                    <Tag value="LumenSegment" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="JPPbis0Vgk2Gn_FzQPbeJw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="2q6TBXJk6kClLPMl9SkuEA" name="FillLevelFlag" description="Fill Level Flag" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Lumen_PKSim.PARAM_FillLevelFlagFlag" visible="0" canBeVaried="1" />
-                    <Parameter id="CxeiFTtup0qjTweJcTmdvw" name="Volume (gut wall)" description="Volume of the gut wall" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="MucosaVolume_Human.PARAM_VolumeGutWall_ColonDescendens" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Parameter id="WWBaKgnndkeL-bzpfS6jdQ" name="Distal radius" description="Distal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R2" visible="1" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="bwkDiCqf10aMf5-nqion7Q" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Lumen_PKSim.PARAM_FillLevel" visible="0" canBeVaried="1" />
-                    <Parameter id="lZ5K6zuN_EKybNuJT47Idw" name="Geometric surface area" description="Geometric surface area of GI segment" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Area" visible="1" canBeVaried="1" displayUnit="cm²" />
-                    <Parameter id="3b_esGVtAEmGV3CsphyQAQ" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_InverseLITT_Factor_ColonDescendens" visible="0" canBeVaried="1" displayUnit="1/min" />
-                    <Parameter id="ZePc7CQyZUevbMFRf73oHw" name="Length" description="Length" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Length" visible="1" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="LMNHKDp86USSPKhw7QO1CQ" name="Liquid" description="Liquid" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Liquid_StartValue" visible="0" canBeVaried="1" rHSFormula="Lumen_PKSim.LiquidRHS_coldesc" displayUnit="l" />
-                    <Parameter id="r6rGdVtJZEqC0AXGrh7jDg" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Lumen_PKSim.PARAM_LiquidTransferRate_coldesc" visible="0" canBeVaried="0" displayUnit="l/min" />
-                    <Parameter id="J3vIX6TKcE64d0k7dj3-Vg" name="Proximal radius" description="Proximal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R1" visible="1" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="s05fQHumS0ePq2aBsxgLbQ" name="Secretion of liquid" description="Rate of liquid inflow" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Inflow_ColonDescendens" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="OK211TNrxUSDj2lZ_PAWnw" name="Thickness of gut wall" description="Thickness of Gut Wall" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Thickness" visible="0" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="7EuxnfjxekidTLHrqPlImA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_LumenSegment" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Parameter id="bJMrKyEa_UmFYjDgmkhSIQ" name="Absorption of liquid" description="rate of liquid outflow" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Outflow_ColonDescendens" visible="0" canBeVaried="1" displayUnit="1/min" />
-                    <Parameter id="8pZqE7Ew9EufC3lZulK6xw" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0384322177" displayUnit="cm" />
-                    <Parameter id="mheDbwTcAUifEXcxUgQ95w" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.008955843" />
-                    <Parameter id="kf6bOgmP5Eq56RH_I2Q8zA" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0384322177" displayUnit="cm" />
-                    <Parameter id="NMvkPOeffUepBCJBsQoMAg" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="6.6" />
-                    <Parameter id="Dv5Y2WSdcUG3SwJxUBSeLQ" name="Microvilli factor" description="Microvilli factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                    <Parameter id="K1-dnJPe4kagqDIRz1Sv-g" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.098514277" />
-                    <Parameter id="6HTC_22umkGK7owYRG8uCw" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.4227543951" displayUnit="cm" />
-                    <Parameter id="xDueeX37Rk-lcgYyr0M7Ug" name="Intestinal transit rate" description="Transit rate along intestinal segments" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" visible="0" canBeVaried="1" value="5" displayUnit="1/min" />
-                    <Parameter id="dPeDH9iJa0OaRC0lzpYhug" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.008955843" />
-                    <Parameter id="CAQoaHWi-kSqLaKsV511SQ" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.08977747" displayUnit="1/cm" />
-                    <Parameter id="cpwe1pz8pUu3f-kV9seMTw" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0601543776" displayUnit="cm" />
-                    <Parameter id="7abQHH2kYUKe78hQFALocw" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0118" displayUnit="cm" />
-                    <Parameter id="Re0TpYGIdke80p9DSAdWsw" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0060009" />
-                    <DistributedParameter id="RQ0B8C2KbU23zsvv_ZcWaA" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="kqo1eEwQOEOjH8pvaWibwg" mode="Logical" visible="1">
-                      <Children>
-                        <Parameter id="nvIWDjeyOUenSvvVl5ZVXA" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                        <Parameter id="p-_B7NVEBU6mXptOnDMIwA" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="2.5" />
-                      </Children>
-                    </DistributedParameter>
-                    <Container id="R-pqh30XUUK6QpD6-HXIWg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Children>
-                        <Parameter id="rdV2_HsRjECElmq8P-XlKw" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" visible="0" canBeVaried="0" />
-                        <Parameter id="syeOci9eX0KuGQNBiwmo3A" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" visible="0" canBeVaried="0" />
-                        <Parameter id="XH7ZSd4MUUupTDFpIyWTKA" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" visible="0" canBeVaried="0" />
-                        <Parameter id="MxfDt0IYdkivgPxJmgux8g" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" visible="0" canBeVaried="0" />
-                        <Parameter id="75w5SSZk7k2ZWBchy4m1HQ" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" visible="0" canBeVaried="0" />
-                        <Parameter id="aP4YDBAG9UmqLW8rLMZ45w" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" visible="0" canBeVaried="0" />
-                        <Parameter id="4xYHk0nu7kmrhbl9eMqnwA" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" visible="0" canBeVaried="0" />
-                        <Parameter id="BHugHV38EEKrsYL-8fqyFw" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" visible="0" canBeVaried="0" />
-                        <Parameter id="QsGsdilvbUafR00_zz62qQ" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" visible="0" canBeVaried="0" rHSFormula="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_coldesc" value="0" displayUnit="µmol" />
-                        <Parameter id="A1_2XuGWh0ydeFL3smRidA" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" visible="0" canBeVaried="0" />
-                        <Parameter id="JlcYFtfDiESu_ddErUVKTg" name="Solubility" description="Solubility" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" formula="Lumen_PKSim.PARAM_IntestinalSolubility" visible="1" canBeVaried="1" displayUnit="mg/l" />
-                        <Parameter id="9RZeIsRrGUC398cehNn8vQ" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" visible="0" canBeVaried="0" />
-                        <Parameter id="lxp1K_PUvUigoWkcEIiH1A" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" visible="0" canBeVaried="0" />
-                        <Parameter id="dSyK-ssDVky6bZqJL4P63A" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" visible="0" canBeVaried="0" />
-                        <Parameter id="KH9JE-CD7keusGhpi1PMGg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="0" value="1" />
-                        <Parameter id="UW49vSXPRkiQF5lplkd2rg" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal_GI" visible="0" canBeVaried="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="pXPUliiKakqWhra3psEI6A" name="ColonSigmoid" description="Colon Sigmoid / Distal Colon 2" icon="ColonSigmoid" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Lumen" />
-                    <Tag value="LumenSegment" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="YsjLT6nVBkyuiuc50NYxTw" name="Thickness of gut wall" description="Thickness of Gut Wall" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Thickness" visible="0" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="80duGiPweE6T_db8lbmMjw" name="Absorption of liquid" description="rate of liquid outflow" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Outflow_ColonSigmoid" visible="0" canBeVaried="1" displayUnit="1/min" />
-                    <Parameter id="Gm1tTQsomkyQGALOQV_FDw" name="Distal radius" description="Distal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R2" visible="1" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="G_05qeVMLUi-Yv-xOXBhzw" name="FillLevelFlag" description="Fill Level Flag" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Lumen_PKSim.PARAM_FillLevelFlagFlag" visible="0" canBeVaried="1" />
-                    <Parameter id="Z6CbSZBRUESnXvBH9OgoKA" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Lumen_PKSim.PARAM_FillLevel" visible="0" canBeVaried="1" />
-                    <Parameter id="bJHN7B0lhE6XfMcwZtzGbQ" name="Geometric surface area" description="Geometric surface area of GI segment" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Area" visible="1" canBeVaried="1" displayUnit="cm²" />
-                    <Parameter id="uuzLgg7asUmInJ6v0eeIjw" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_InverseLITT_Factor_ColonSigmoid" visible="0" canBeVaried="1" displayUnit="1/min" />
-                    <Parameter id="I78kEk90ukelVcoLJVXkIg" name="Length" description="Length" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Length" visible="1" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="sdAYqWoqAU2xY76KPK3ADA" name="Liquid" description="Liquid" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Liquid_StartValue" visible="0" canBeVaried="1" rHSFormula="Lumen_PKSim.LiquidRHS_colsigm" displayUnit="l" />
-                    <Parameter id="rDOZfPXSJkGLg9mJoLua9w" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Lumen_PKSim.PARAM_LiquidTransferRate_colsigm" visible="0" canBeVaried="0" displayUnit="l/min" />
-                    <Parameter id="gjs5TG2XKUWL9jw_WJEl6w" name="Proximal radius" description="Proximal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R1" visible="1" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="QJLVo71EPkSkgPPQNK6Etg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_LumenSegment" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Parameter id="xZsoMHEoPEC9OHB5WAL0Og" name="Volume (gut wall)" description="Volume of the gut wall" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="MucosaVolume_Human.PARAM_VolumeGutWall_ColonSigmoid" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Parameter id="_H41YSQ9V0mBjSPMyAy-uw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="mGnM1yjbn0-HCwxDhja_0Q" name="Secretion of liquid" description="Rate of liquid inflow" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Inflow_ColonSigmoid" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="V6Pw2aM8MUOt-yet8vBDUA" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0384322177" displayUnit="cm" />
-                    <Parameter id="h_9d6veLskm8zroduvw-bQ" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0889014" displayUnit="1/cm" />
-                    <Parameter id="YBckwuTmOEG7KwHBbmXQBA" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0274432593" displayUnit="cm" />
-                    <Parameter id="wzy8vh3oJEGjWy0M6jErGA" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.00536" displayUnit="cm" />
-                    <Parameter id="Z-XahOfxik2Nn5QEDvlDJQ" name="Intestinal transit rate" description="Transit rate along intestinal segments" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" visible="0" canBeVaried="1" value="4.0741" displayUnit="1/min" />
-                    <Parameter id="GU6ejEeLDE2yhvffdGL4kw" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.008955843" />
-                    <Parameter id="zQoae5KsGkO3-jzzEjf5Ug" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0384322177" displayUnit="cm" />
-                    <Parameter id="GebMMpBYTEWzW1lZe0jxLg" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="6.6" />
-                    <Parameter id="iSuSGlWC8kW28RTcOBDD-g" name="Microvilli factor" description="Microvilli factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                    <Parameter id="czTe5iyWG0mwxn-VaVpFeA" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.121300709" />
-                    <Parameter id="2ssQPm08tk-EUyEasD9oDw" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.008955843" />
-                    <Parameter id="Wnn3JO5H2UGu5Vu_cFgfdA" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5337898629" displayUnit="cm" />
-                    <Parameter id="8vhZJ7rYAkinhCYKa6pi7Q" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0060009" />
-                    <DistributedParameter id="W_TukGPM-kqTUIl_jOLCWg" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="qmmQKfipOUumylARX1ZrIQ" mode="Logical" visible="1">
-                      <Children>
-                        <Parameter id="3sxId5YMYUmnE2SnJFT04Q" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                        <Parameter id="VCK3GBALAkiQtLx6lRe3DA" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="2.5" />
-                      </Children>
-                    </DistributedParameter>
-                    <Container id="yRzo1ictaES6H13zffgEvA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Children>
-                        <Parameter id="6aDeiMnC4UubtLcnn-2Tqg" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" visible="0" canBeVaried="0" />
-                        <Parameter id="qrRzL19REE6Xu1T6Oa-WTw" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" visible="0" canBeVaried="0" />
-                        <Parameter id="9NUpSpu1DUm0MznodYaYhA" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" visible="0" canBeVaried="0" />
-                        <Parameter id="RsbYFJvz1k-dYsCBtmtfRQ" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" visible="0" canBeVaried="0" />
-                        <Parameter id="W3cHRvqN4UGZeHAcj5aUnA" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" visible="0" canBeVaried="0" />
-                        <Parameter id="sBswIJi_RESVWEFIJnydvA" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" visible="0" canBeVaried="0" />
-                        <Parameter id="2HgSSFsBvEqQXjb7Ht53hQ" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" visible="0" canBeVaried="0" />
-                        <Parameter id="VxA_6HPSGk-BUqWGApij1Q" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" visible="0" canBeVaried="0" />
-                        <Parameter id="IC2p0knMc0eYhMlV92Q81A" name="Solubility" description="Solubility" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" formula="Lumen_PKSim.PARAM_IntestinalSolubility" visible="1" canBeVaried="1" displayUnit="mg/l" />
-                        <Parameter id="djNxWx98mEKJDDuV4AyN2Q" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" visible="0" canBeVaried="0" />
-                        <Parameter id="Kn_MXnXpv0KnJoq_qoNy-g" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" visible="0" canBeVaried="0" />
-                        <Parameter id="lUiJEQR6tEmBlVFc1wGaHQ" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" visible="0" canBeVaried="0" />
-                        <Parameter id="1B6Ul5UgN0mQdASKPWnAyQ" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal_GI" visible="0" canBeVaried="0" />
-                        <Parameter id="7rJvGMajGE2MfG_AmbrpXw" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" visible="0" canBeVaried="0" rHSFormula="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_colsigm" value="0" displayUnit="µmol" />
-                        <Parameter id="Ymvaw4xS8UmXOHBEprVcAg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="0" value="1" />
-                        <Parameter id="H5xmNMFmGkS855PBnoQy1g" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" visible="0" canBeVaried="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="tl7DiBQWEUGwcvPUXLf68w" name="Rectum" description="Rectum" icon="Rectum" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Lumen" />
-                    <Tag value="LumenSegment" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="YlXgaX0SZUO_72WirfTg5Q" name="Length" description="Length" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Length" visible="1" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="xVj1VWPUQkiACNLMA52bWw" name="Absorption of liquid" description="rate of liquid outflow" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Outflow_Rectum" visible="0" canBeVaried="1" displayUnit="1/min" />
-                    <Parameter id="PsSmN87CSEGZaTFs1ns-sA" name="Distal radius" description="Distal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R2" visible="1" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="JrnTqYh7pk2RjYA6HDydwQ" name="FillLevelFlag" description="Fill Level Flag" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Lumen_PKSim.PARAM_FillLevelFlagFlag" visible="0" canBeVaried="1" />
-                    <Parameter id="69NR94g5F0y9qTMbzMkPnw" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Lumen_PKSim.PARAM_FillLevel" visible="0" canBeVaried="1" />
-                    <Parameter id="aacNf71BTEuUuiKxe849xg" name="Geometric surface area" description="Geometric surface area of GI segment" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Area" visible="1" canBeVaried="1" displayUnit="cm²" />
-                    <Parameter id="ZgTYQBhWHkyVlAhhVqP68Q" name="Liquid" description="Liquid" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Liquid_StartValue" visible="0" canBeVaried="1" rHSFormula="Lumen_PKSim.LiquidRHS_rect" displayUnit="l" />
-                    <Parameter id="MO3YURFIsU-2FZCq8O4XNA" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_InverseLITT_Factor_Rectum" visible="0" canBeVaried="1" displayUnit="1/min" />
-                    <Parameter id="Wvh-zZ8YLE6tQQhKN_ZWBw" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Lumen_PKSim.PARAM_LiquidTransferRate_rect" visible="0" canBeVaried="0" displayUnit="l/min" />
-                    <Parameter id="HkYmf5I1zkOgF6yvtq4HDw" name="Proximal radius" description="Proximal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R1" visible="1" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="oqmbPP12YkCcI2d5QdFgIw" name="Secretion of liquid" description="Rate of liquid inflow" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Lumen_PKSim.PARAM_Inflow_Rectum" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="aCR3ED5PKUKj0WwoO3IRaw" name="Thickness of gut wall" description="Thickness of Gut Wall" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Thickness" visible="0" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="SelVqTz8D0GhOwZkoLLYWw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_LumenSegment" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Parameter id="DNC8fUvhpkmJpWcht3wEcg" name="Volume (gut wall)" description="Volume of the gut wall" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="MucosaVolume_Human.PARAM_VolumeGutWall_Rectum" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Parameter id="68D8yfnNMUSyjqMarnw7Jg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="lcrwGmpwHEaZuy-eTSwQyQ" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0060009" />
-                    <Parameter id="T0PJXS5KdEGw179dHZLRKQ" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0324721331" displayUnit="cm" />
-                    <Parameter id="tEJL2rnKBUOGu7ZNsIV5LA" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.00665" displayUnit="cm" />
-                    <Parameter id="eN5lTtLC_k2QcGMWd5QQIg" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.005597402" />
-                    <Parameter id="6pxTokB51EeL1-UwJx1U1Q" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0240201361" displayUnit="cm" />
-                    <Parameter id="-z2E2ep5mUa7PSbnFivZyQ" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.008955843" />
-                    <Parameter id="GB8obBOiMkOWJnygDOnVEw" name="Intestinal transit rate" description="Transit rate along intestinal segments" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" visible="0" canBeVaried="1" value="315.618" displayUnit="1/min" />
-                    <Parameter id="e44ieTMvjEmj3YLmcothDg" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.1569046761" displayUnit="cm" />
-                    <Parameter id="JRM8Su2tQEmydiznHFCCVA" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="6.6" />
-                    <Parameter id="UIsx4W4TAEe-Vzlza8LB_Q" name="Microvilli factor" description="Microvilli factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                    <Parameter id="bu39yV-zz0KR9R9agG47AA" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.052420808" />
-                    <Parameter id="aLkKO2jsSkK8KE8Q2ENp8Q" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0384322177" displayUnit="cm" />
-                    <Parameter id="Gd_vpodpQke2WC0ubguO6Q" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.10014267" displayUnit="1/cm" />
-                    <DistributedParameter id="8DVvyVzGIUS0ET6V7IrNCw" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="QhMDrLLqME6_kdhC0-2gEw" mode="Logical" visible="1">
-                      <Children>
-                        <Parameter id="hVn8QGTYVEGh7e9GKUnLew" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                        <Parameter id="oU3n1PIKtkeZfCo8zmMbOw" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="3.56" />
-                      </Children>
-                    </DistributedParameter>
-                    <Container id="DqsgrYovFESGgnpDM2L4Bg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Children>
-                        <Parameter id="m-ZgEIoUckuUBd8JUt4FjA" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" visible="0" canBeVaried="0" rHSFormula="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_rect" value="0" displayUnit="µmol" />
-                        <Parameter id="LbqxGhB-ykmbTRcba_zQOw" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" visible="0" canBeVaried="0" />
-                        <Parameter id="g4UD4MsknkyQsoq6lIRQ1g" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" visible="0" canBeVaried="0" />
-                        <Parameter id="xXub-m6Ow0unhEKyuZ1zqQ" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" visible="0" canBeVaried="0" />
-                        <Parameter id="Gt22bDsAtkG5ITY-C8xr2g" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" visible="0" canBeVaried="0" />
-                        <Parameter id="q6ljMOztkEmG_AP8xot7oQ" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" visible="0" canBeVaried="0" />
-                        <Parameter id="h5LptsJD1UGOd3A6Fa3DLw" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" visible="0" canBeVaried="0" />
-                        <Parameter id="NPrPiT9n90SkJLdeOoyIGw" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" visible="0" canBeVaried="0" />
-                        <Parameter id="iofUkf6X3UmYFDLPladKBA" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" visible="0" canBeVaried="0" />
-                        <Parameter id="DH0ef0OARkWL0awIFclX8g" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" visible="0" canBeVaried="0" />
-                        <Parameter id="Y2Hv951DXUancXBohrcaog" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" visible="0" canBeVaried="0" />
-                        <Parameter id="AiegBU2xU0iDMxil9qTdZA" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" visible="0" canBeVaried="0" />
-                        <Parameter id="e-Ijoe_dx0yqZD1HMV8kkA" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" visible="0" canBeVaried="0" />
-                        <Parameter id="3A-xz8MRF0WEny7HVBMjLA" name="Solubility" description="Solubility" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" formula="Lumen_PKSim.PARAM_IntestinalSolubility" visible="1" canBeVaried="1" displayUnit="mg/l" />
-                        <Parameter id="h0Nz4rlcz0ayJlv5ev5MiA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal_GI" visible="0" canBeVaried="0" />
-                        <Parameter id="OiHyRUAZQU6jA0BIKWheYw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="0" value="1" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="bhSAzpl7HkaX9dPtBlqhGQ" name="Feces" description="Feces compartment used to collect the fraction excreted of the compound from the instestinal wall into the gut lumen." mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Lumen" />
-                    <Tag value="LumenSegment" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="ey87j1hB1UqjWJBuFnB4hQ" name="Liquid" description="Liquid" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" rHSFormula="Lumen_PKSim.LiquidRHS_fec" value="0" displayUnit="l" />
-                    <Parameter id="RwxkyL8CtE60Vx3nybg5Rg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="l" />
-                  </Children>
-                </Container>
-              </Children>
-            </Container>
-            <Container id="W9QLxnnS7UiEKTcDH8G9OA" name="Stomach" description="Stomach" icon="Stomach" mode="Logical" containerType="Organ">
-              <Tags>
-                <Tag value="Portal Vein Supplying Organ" />
-                <Tag value="TissueOrgan" />
-              </Tags>
-              <Children>
-                <Parameter id="cCHAGjhjyUuJfsAaHHP5xA" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="Individual_PKSim.PARAM_Tissue_Weight" visible="0" canBeVaried="1" displayUnit="kg" />
-                <Parameter id="P-DLfwWLMkq15SJElgM9Dg" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="VascularEndoVolume.VOLUME_VascularEndo_sto" visible="1" canBeVaried="0" displayUnit="l" />
-                <Parameter id="L-y4dgIbGke44txJy2bKLQ" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Lymph_flow_rate_Stomach" visible="1" canBeVaried="1" displayUnit="l/min" />
-                <Parameter id="cA5-5dqSR0i6Q_Z-915_7Q" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate_Stomach" visible="1" canBeVaried="1" displayUnit="l/min" />
-                <Parameter id="EQ6hEd3EJESeimlOHmEjrg" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_f_cell" visible="1" canBeVaried="1" />
-                <Parameter id="gLHvc3ybgUGJ0Pbo3FLWzw" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Q_from_Qspec" visible="1" canBeVaried="1" displayUnit="l/min" />
-                <Parameter id="KsBSXPR02U25G3EkuLPvaw" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                <Parameter id="5ONtsDqF_kSJ2_xjLcWpPA" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.75" />
-                <Parameter id="YiPJvXqag0Ksw-7N84fq2g" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                <Parameter id="HpKS4t-uOE-z43njf5g73Q" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="4.5E-08" displayUnit="µm" />
-                <Parameter id="8iD8qPQ1bki0-DFpyd3U6A" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="2.5E-07" displayUnit="µm" />
-                <Parameter id="ImnZG9AuJkm7wdBEjq723A" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" visible="1" canBeVaried="1" value="3.97222222222222E-11" displayUnit="ml/min/N" />
-                <Parameter id="XnTyUwMOcEK6G2tJ51QKZw" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.05" />
-                <Parameter id="8sApSb3IwUKWYqyH9PBiIA" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0487" />
-                <Parameter id="YRPw_bDQ7UaKhfbZ8TdVCg" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.062" />
-                <Parameter id="DtS5aOA0RkuBIRlIuJTbBA" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.032" />
-                <Parameter id="mjfNuA6fRU2wTTvxVWpZjg" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.133" />
-                <Parameter id="VoNzfU7nVUGRtC_ODHSI5A" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0163" />
-                <Parameter id="eUDYrHvtRU2x0x2yXKYpuw" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.718" />
-                <Parameter id="eJzA-X6aSUO1xEHurAKN1g" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.792" />
-                <Parameter id="v7-bEq-v0kqWMiqic5bEVQ" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.158" />
-                <Parameter id="vIxTwLdh8U-KvBu_vhF0ng" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.141" />
-                <Parameter id="PthIXoFXVUO9dvWj2svfjA" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-                <Parameter id="rUbuTiAZBE2EONIBxiBMzQ" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.1" />
-                <Parameter id="Kk-I9AjZYUmLjXeVDKmBkw" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0483" />
-                <Parameter id="L8o30Eux50KKGTghziE3XQ" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0375" />
-                <Parameter id="qES43LlhwkGR2bIykYnamQ" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0182" />
-                <Parameter id="P7wjYtKEn0uzvUkzNpaXnQ" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0124" />
-                <Parameter id="dFP73tri9UaZo7U8Oyx_8g" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.282" />
-                <Parameter id="DBWN0iE8gU-G8_QT8bVBYA" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.15" />
-                <Parameter id="smwWenkemEeUFY7g3N_0GQ" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.78" />
-                <Parameter id="wwv97_rCxka6mw0ZEZbVug" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.456" />
-                <Parameter id="J7GwrTm4E0CPHheN3XqbAg" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0035" />
-                <Parameter id="KQJA-zKcpUy4EkGXnz0RPw" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="2.41" />
-                <DistributedParameter id="_0ETAhvtjEmaHJXeVDdgGw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="IrEpekZ0y0ChdmYHyVh2Qg" mode="Logical" visible="1" displayUnit="l">
-                  <Children>
-                    <Parameter id="t6pU14V9zkW8iKE-Ssn8FQ" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.500397173769471" displayUnit="l" />
-                    <Parameter id="Gs-jxjzqEUuRfqTjVlQN6w" name="Mean" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" value="0.135729408786912" displayUnit="l" />
-                    <Parameter id="00dkCAdw3Eel3xlBIaRGHw" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0203594113180368" displayUnit="l" />
-                  </Children>
-                </DistributedParameter>
-                <DistributedParameter id="Ap4MZ8D5wkiQNqM8T9mCCA" name="Specific blood flow rate" description="Blood flow rate normalized to the organ volume" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" formula="W9wr-L44V067gUs4MkrARA" mode="Logical" visible="1" displayUnit="ml/min/100g organ">
-                  <Children>
-                    <Parameter id="AIoaeTd-IESD42uGZoNp-Q" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" displayUnit="ml/min/100g organ" />
-                    <Parameter id="4jeiAvOivEOY8mZcxDYTMg" name="Mean" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" visible="0" canBeVaried="1" value="0.3861" displayUnit="ml/min/100g organ" />
-                    <Parameter id="N8l4m6NtTky228_bMzR7kg" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" visible="0" canBeVaried="1" value="0.019305" displayUnit="ml/min/100g organ" />
-                  </Children>
-                </DistributedParameter>
-                <Container id="wcVwGWqUikGrxah1-6Vx6A" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Portal Vein Supplying Organ" />
-                    <Tag value="Stomach" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="2iKsdVhwiEuvHgYd2UJSDg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="dNTWo5H3dEuS36IH1hFPhw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Container id="jfthzMPt0UemB0VRdWo15Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Children>
-                        <Parameter id="e2FS3xQHTkiLFBF5An7B0A" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                        <Parameter id="XdyoCPVrCU2_3AG5xb0-dg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" visible="0" canBeVaried="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="ZsgRGsl2Ika6nIUVelD34g" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Portal Vein Supplying Organ" />
-                    <Tag value="Stomach" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="2MdA68k-vEGFNxXAwAiZfw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="POnhDS1bb0Kwn-FCYZtDXA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Container id="a6BeVPKQ2kqox1tFvfKoXA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Children>
-                        <Parameter id="DCLzhaBnuUG3Cf_UPbBUgw" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                        <Parameter id="LHdDajn9W0WIx_WJtRY74w" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" visible="0" canBeVaried="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="pkdR9CiDHEq7nh4GTlLyVA" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Portal Vein Supplying Organ" />
-                    <Tag value="Stomach" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="l7r1FOJCW06SaknVJmpX_Q" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="f_TfHaCeuUiEmZgpSashCA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Parameter id="5Om6q_jdCkiNNRIMWC-CUQ" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_pH_INT" visible="1" canBeVaried="1" />
-                    <Container id="g1J10NpFNEmBlO59g2jo2Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Children>
-                        <Parameter id="V3yDGIVtC0WgBLvdRXsOVw" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                        <Parameter id="4a1zb29KUEWt-INvFfYuYw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_sto" visible="0" canBeVaried="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="Mur3m3tL10Ga-Q6Mn5phPg" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Portal Vein Supplying Organ" />
-                    <Tag value="Stomach" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="ilf7CNAYREiFSGwOlAOH9A" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="uEaIcua-tUuaDTa3QHtY9Q" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Parameter id="SdSGm3yme02xEQG6R5sF1A" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.4" />
-                    <Container id="U183ynwmeUya0vGmYyos1w" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Children>
-                        <Parameter id="YXjk1Cs02kWm9_WoDaSFUA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                        <Parameter id="8qiBq0nC6kOyA-22xjZszg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_sto" visible="0" canBeVaried="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-              </Children>
-            </Container>
-            <Container id="_Ea-hm3uwEOFN5aefJGDLA" name="SmallIntestine" description="SmallIntestine" icon="SmallIntestine" mode="Logical" containerType="Organ">
-              <Tags>
-                <Tag value="Portal Vein Supplying Organ" />
-                <Tag value="TissueOrgan" />
-              </Tags>
-              <Children>
-                <Parameter id="OZsXfD9wK0Gn6SLmLS79Vw" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="Individual_PKSim.PARAM_Tissue_Weight" visible="0" canBeVaried="1" displayUnit="kg" />
-                <Parameter id="KSWj1kDT1EC3tDScTtFCmQ" name="Small intestinal transit time factor" description="Small intestinal transit time factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Lumen_PKSim.PARAM_SITT_Factor" visible="0" canBeVaried="1" />
-                <Parameter id="emDHR4kTg0-WE7hpIj0Zbg" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Q_Lymph_sin" visible="1" canBeVaried="0" displayUnit="l/min" />
-                <Parameter id="9Ci8B3VY3kKpg-mJTk1YVw" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="VascularEndoVolume.VOLUME_VascularEndo_sin" visible="1" canBeVaried="0" displayUnit="l" />
-                <Parameter id="Wrn-iltJ8EiP1fmKUZWaAg" name="Lymph flow rate (incl. mucosa)" description="Lymph flow rate (incl. mucosa)" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Lymph_flow_rate_(incl._mucosa)_SmallIntestine" visible="1" canBeVaried="1" displayUnit="l/min" />
-                <Parameter id="aB_X3VldU0Kdnh-AEgMFYA" name="Fluid recirculation flow rate (incl. mucosa)" description="Fluid recirculation flow rate between plasma and interstitial space (incl. mucosa)" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate_(incl._mucosa)_SmallIntestine" visible="1" canBeVaried="1" displayUnit="l/min" />
-                <Parameter id="XlnWakV3WkOEegrFbsQHhQ" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_FluidRecirculationRate_sin" visible="1" canBeVaried="0" displayUnit="l/min" />
-                <Parameter id="tf3UPmubpEus2z2YHXL-XQ" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_f_cell" visible="1" canBeVaried="1" />
-                <Parameter id="rFv6d3S6y0uusJJ3wuKJfw" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Q_from_Qspec" visible="1" canBeVaried="1" displayUnit="l/min" />
-                <Parameter id="OJhfMVoJ0E2L_DDxcRcFwg" name="Volume (mucosa)" description="Volume of mucosa" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="MucosaVolume.VOLUME_SmallIntestineMucosa" visible="1" canBeVaried="1" displayUnit="l" />
-                <Parameter id="_hwx8LBAakeTTO-i_PYoJg" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                <Parameter id="YgozUXsV2EuSC54mkmxGPQ" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.75" />
-                <Parameter id="R9Sky5Eqj0K3ddUQPRD_ig" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                <Parameter id="5KnpCg6VL0iL1E4BDTzdWg" name="Small intestinal transit time factor slope" description="Small intestinal transit time factor slope" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" visible="0" canBeVaried="0" value="0.602" displayUnit="1/min" />
-                <Parameter id="EIR9PdKEhkS9ZJr_fVThfA" name="Small intestinal transit time factor intercept" description="Small intestinal transit time factor intercept" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="0" value="-4.52" />
-                <Parameter id="MuGHhFubMUSKQKpnbd-LIg" name="Mucosa blood flow fraction" description="Blood fraction which goes to mucosa" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.75" />
-                <Parameter id="FKdTk54dT0ajlH43LfJhNA" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="4.5E-08" displayUnit="µm" />
-                <Parameter id="phn_yo7I9UeKNig5HMcJuQ" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="2.5E-07" displayUnit="µm" />
-                <Parameter id="i8HwWJTq9kC6FnAKTMfkBA" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" visible="1" canBeVaried="1" value="1.53888888888889E-10" displayUnit="ml/min/N" />
-                <Parameter id="R1oy6tT3eE28AgptC_FWXw" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.05" />
-                <Parameter id="n9qm8aFu1k6KSHfZSEhJAQ" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0487" />
-                <Parameter id="KxUu0fMkY0utNgky4mVArA" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.062" />
-                <Parameter id="3V74NHaU7kWw9eX1QerMWg" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.024" />
-                <Parameter id="dP6joaeADkKrV-9m1SfALA" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.133" />
-                <Parameter id="7qZ4VjR5wkWMFsqnhRWzmQ" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0163" />
-                <Parameter id="s8FrfwQifkCho7ZmBvUnzw" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.718" />
-                <Parameter id="EpyVr2AFKE2Sr7tSsQX3yw" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.792" />
-                <Parameter id="-V0STFwIvUa1TVWCP1yk4A" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.158" />
-                <Parameter id="K2RXGuJKukmSj55ghjhN6w" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-                <Parameter id="7c9ebyiKw06ht4qE66SriQ" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.141" />
-                <Parameter id="6X-WdKTFEkC38uog0AwDcA" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.094" />
-                <Parameter id="sspGpbzSHk6aS-_zB4V3sQ" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0483" />
-                <Parameter id="VrBeYMalzkOzgptlmU1PEw" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0375" />
-                <Parameter id="D9Qwi_fPZk2OVpKiSiHgMQ" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0124" />
-                <Parameter id="YrqTHRfHQEutYIgix0J2LQ" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0182" />
-                <Parameter id="E_TEwYy5MUSuaS1fb1kLKg" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.15" />
-                <Parameter id="9Cmo-htw-UGCe1sNF2aC3g" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.282" />
-                <Parameter id="UArNFXmzjUSairD_afYltg" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.456" />
-                <Parameter id="93sOJ-GvMkCnfbchJLTJbQ" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.78" />
-                <Parameter id="eaQF-cvqSUeVaIFHCa2BfA" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0035" />
-                <Parameter id="-uB6jIW9m02BupaKQJDJbA" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="2.41" />
-                <DistributedParameter id="vmstbVr5zUe93VCWHjRW5A" name="Small intestinal transit time" description="The time required for the passage of a non-absorbable compound through the small intestine, defined as the time span between gastric emptying (i.e. the point at which 63% of the drug mass has entered the duodenum) and the time at which 90% has entered the caecum" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" formula="CT81_q1m8kibZgEvnslgZw" mode="Logical" visible="1" displayUnit="h">
-                  <Children>
-                    <Parameter id="GQX39tV7C0u-SMEIi0dwHw" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" displayUnit="h" />
-                    <Parameter id="URvG0hQNhEGB_fNJ92wuFA" name="Mean" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" visible="0" canBeVaried="1" value="126" displayUnit="h" />
-                    <Parameter id="Uv_YlZeS9EW8jOcAbzO0sA" name="GeometricDeviation" description="Geometric standard deviation of LogNormal distribution" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1.6" />
-                  </Children>
-                </DistributedParameter>
-                <DistributedParameter id="ip-iWzvUEkyNHJeI5D1dKg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="UxMd-T6oWUKbVPL7l5TuEQ" mode="Logical" visible="1" displayUnit="l">
-                  <Children>
-                    <Parameter id="dqNaN6oyLE--iRnlwIR2-A" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.50153257191455" displayUnit="l" />
-                    <Parameter id="SagLCWmKUUWmUfMaZALvRQ" name="Mean" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" value="0.58335271881664" displayUnit="l" />
-                    <Parameter id="ffkNIzPOaUKJCFwOBtfHbQ" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0682572317087829" displayUnit="l" />
-                  </Children>
-                </DistributedParameter>
-                <DistributedParameter id="AKDfft4UFU2cB92i2ZBXNA" name="Specific blood flow rate" description="Blood flow rate normalized to the organ volume" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" formula="E-JBU_WK8kOf1T816pxQ1g" mode="Logical" visible="1" displayUnit="ml/min/100g organ">
-                  <Children>
-                    <Parameter id="grFZXr9YP0u_Epu4-Wl4yQ" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" displayUnit="ml/min/100g organ" />
-                    <Parameter id="voLBJMvbeUaHDilxljpDnQ" name="Mean" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" visible="0" canBeVaried="1" value="0.89765" displayUnit="ml/min/100g organ" />
-                    <Parameter id="48TDpNRKLUCLBC6D4aVFgw" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0448825" displayUnit="ml/min/100g organ" />
-                  </Children>
-                </DistributedParameter>
-                <Container id="bKNuXngQSk-SQQe7D3MkAw" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Portal Vein Supplying Organ" />
-                    <Tag value="SmallIntestine" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="yaUOadM960Gm9OojHj5_ww" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="Gq9jTQMjxE-Sl4FdC_luqg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_pls_SinLin" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Container id="EFl2cIHzfk-0Dp1SFrBeLg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Children>
-                        <Parameter id="hc876w2DMk-XXYMefbEqkg" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                        <Parameter id="8FJFuBZu0kS5tufrDLLphQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" visible="0" canBeVaried="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="n6xwS0M17UWg01nLAvRLIQ" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Portal Vein Supplying Organ" />
-                    <Tag value="SmallIntestine" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="NF5tbJ9ShkufqAg3f-Q8Ow" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="5fxflBM6nUa0ixVeurxx5Q" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_bc_SinLin" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Container id="RhJJDln6LEaM-Nc3DxC7EA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Children>
-                        <Parameter id="cP44RnyTiECvTLbMUK0OYA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                        <Parameter id="E8Y4kJzhBUGIW2YIWjDE3Q" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" visible="0" canBeVaried="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="QQEEFQ5iKUyN-6sUySP6Ig" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Portal Vein Supplying Organ" />
-                    <Tag value="SmallIntestine" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="8jc0U-ovREa3qNZZYNnlQA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="YAwXs5KvWU-s1om7bFEPRg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_int_SinLin" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Parameter id="FPrN-u_LcEiMlECWRvMCtw" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_pH_INT" visible="1" canBeVaried="1" />
-                    <Container id="qp-tnDsTkE62q2JDH6Xv1Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Children>
-                        <Parameter id="SYys5K-JrkmLxN5r9LIeyg" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                        <Parameter id="VXYFZtLTnUKaA3uJ9JR13Q" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_sin" visible="0" canBeVaried="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="eTOwNAWOSU2qVPwOLXoz1w" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Portal Vein Supplying Organ" />
-                    <Tag value="SmallIntestine" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="fYgYZ_p9kUSACF8GVBK0yg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ_SinLin" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="jrwV8vzjc0mLYDbQI0u-Mw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_cell_SinLin" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Parameter id="78qznXrnVUyFOXTmuDHTWg" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.4" />
-                    <Container id="Q98iG_DO2UWl8noBNbl81Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Children>
-                        <Parameter id="e5OgQU6K7UWpEnhHPse3UQ" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                        <Parameter id="1FvnQJWUGE-dEta7dGTAEg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_sin" visible="0" canBeVaried="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="1BiQUG4N_kaCCjAnOK4Mbg" name="Mucosa" description="Mucosa" mode="Logical" containerType="Compartment">
-                  <Children>
-                    <Container id="WBQ34pZOtUKe5yiyOlzvFg" name="Duodenum" description="Duodenum" icon="Duodenum" mode="Logical" containerType="Compartment">
-                      <Children>
-                        <Parameter id="RXmxohnS_k6PoAJbu0D6-w" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="Individual_PKSim.PARAM_Tissue_Weight" visible="0" canBeVaried="1" displayUnit="kg" />
-                        <Parameter id="Un0yBWeyd06Vv9QRDnIUMA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="MucosaVolume.VOLUME_MucosaDuodenum" visible="1" canBeVaried="1" displayUnit="l" />
-                        <Parameter id="1_l80-8v_0e1kWgqYBZJOQ" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="VascularEndoVolume.VOLUME_VascularEndo_duo" visible="1" canBeVaried="0" displayUnit="l" />
-                        <Parameter id="JvefbLGQx0iSsIijaAoqew" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Q_lymph_mucosa" visible="1" canBeVaried="1" displayUnit="l/min" />
-                        <Parameter id="3jRx_XCKA0GcO1ZSlfmZew" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_J_iso_Mucosa" visible="1" canBeVaried="1" displayUnit="l/min" />
-                        <Parameter id="cEkuoikfkkq4jU-LIRcRYw" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Q_mucosa" visible="1" canBeVaried="1" displayUnit="l/min" />
-                        <Parameter id="1roxrSN2W0uqJhWq7Ejx7A" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_f_cell" visible="1" canBeVaried="1" />
-                        <Parameter id="WoZwi4nuoEKGEtDa_2nQiQ" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                        <Parameter id="377aJ6FYGUihewBcZDij7w" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                        <Parameter id="jDd4JU5qqUygP7fE4TyUTw" name="Fraction of regional blood flow rate" description="Regional blood flow fraction supplying the mucosal tissue of the segment" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.093" />
-                        <Parameter id="Eq0tMzGbLkSZU1g4t8CJug" name="Fraction mucosa" description="Mucosal fraction of regional intestinal tissue mass" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.26" />
-                        <Parameter id="-FyBDtM6RECOyKnSoekG7g" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" visible="1" canBeVaried="1" value="1.53888888888889E-10" displayUnit="ml/min/N" />
-                        <Parameter id="3EsOzh-9rka5GpWClZXlWw" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="2.5E-07" displayUnit="µm" />
-                        <Parameter id="EC0zxXkdjkCJFmrP48PlIg" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.05" />
-                        <Parameter id="acLx7Dccd0qlVdzT1YUrEA" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="4.5E-08" displayUnit="µm" />
-                        <Parameter id="jpqU61Qpwk2DVQ3KfmW7HA" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.06" />
-                        <Parameter id="clZ1aDvI2EKAPoY67KbhJA" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0487" />
-                        <Parameter id="Ce72cUd60E-_pNoRXmZA_Q" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.13" />
-                        <Parameter id="-pSmh2Mb8k2UoxFiSFQxfQ" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0163" />
-                        <Parameter id="celdHga7mkqrKSllnlG-aw" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.08" />
-                        <Parameter id="TufP_FpKDUeA2V4e91HrMg" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.158" />
-                        <Parameter id="Aqj2aW67CUu2ntnwtmTiFg" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.141" />
-                        <Parameter id="QXrZADlQTkqTlO60k54_9A" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-                        <Parameter id="OFyxtCS2_Umn0BGh3QXNBg" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.718" />
-                        <Parameter id="5kibWaTjbkC4gZbWndHVdQ" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.8" />
-                        <Parameter id="4AEqrI94TE-Vo7KYWE_YNg" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.42" />
-                        <Parameter id="aZV5OItiEEyZAAwZUC7Nxw" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0483" />
-                        <Parameter id="p76kb_UvmEyvKgUBjg-T-A" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0375" />
-                        <Parameter id="MECjoqJdo0-dhvNNlNTOlg" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0182" />
-                        <Parameter id="gJNvNvuu8kyzGQgDZ4lvog" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0124" />
-                        <Parameter id="VYNUMaaZqkSUxAylgBTN8w" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.15" />
-                        <Parameter id="jFdyBKUXNkeUtqSxXhnbCQ" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.282" />
-                        <Parameter id="J0SjK6xSFES8AC7hYdCrrg" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.456" />
-                        <Parameter id="47Vn82xZF02T3-HcMvXeQA" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.78" />
-                        <Parameter id="Y40Zdq3iRUCh_L0Bv-e8cw" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="2.41" />
-                        <Parameter id="vSpGMPyghEiDgYaXMmi1zg" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0035" />
-                        <Container id="EkzIKZP1wU2_9u7Ncqke-Q" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Duodenum" />
-                            <Tag value="Mucosa" />
-                            <Tag value="SmallIntestineSegment" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="9U8AcWfse0ybnNxvekP3yA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="6E-peO2gEE2v0y1N4CxQwQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                            <Container id="DdXkcxTIKk-j_OG04cR0fw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Children>
-                                <Parameter id="X7P5DT2w70ip-nMLeFPs_A" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" visible="0" canBeVaried="0" />
-                                <Parameter id="OkFxsmN1LUWXpju-G5LpjQ" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="u4Ub16oEtECALrodgFre4w" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Duodenum" />
-                            <Tag value="Mucosa" />
-                            <Tag value="SmallIntestineSegment" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="AMbLtHwR00iEptEpsIuInw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="zzMhkh2z0kucdpHCwZO7zw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                            <Container id="frFXyiK4IESAzS-q8A4V1Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Children>
-                                <Parameter id="KdsGIvnhN0OHf2NfocPpRw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" visible="0" canBeVaried="0" />
-                                <Parameter id="VBSo8QsRRkaxAGFilUeYeA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="rKg54o1HYkOhBkZfi2GWsw" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Duodenum" />
-                            <Tag value="Mucosa" />
-                            <Tag value="SmallIntestineSegment" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="5edUw5kB40yrN73BPxAs-Q" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="Jx26XBI-9kyMAO_Uyvtq-Q" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                            <Parameter id="VK0szYdQE0qYssguaq5C8w" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_pH_INT" visible="1" canBeVaried="1" />
-                            <Container id="Coc6OTfHikeT8S7_mzEPKw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Children>
-                                <Parameter id="yjThw040pEK_Zs-2kl6AIw" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                                <Parameter id="r-gzT0IHy0WuxyAGlGkTVg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_duo" visible="0" canBeVaried="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="V_ZJM8cPkEqPs_Ft62p6cg" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Duodenum" />
-                            <Tag value="IntestinalSecretionSource" />
-                            <Tag value="Mucosa" />
-                            <Tag value="SmallIntestineSegment" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="4w7mEgbgvUuXqMjzE71cAQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="EAZgQO-9qEer8Csit-dIcw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                            <Parameter id="krpCkWgqFUGK_S5C7qAwwA" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.3" />
-                            <Container id="lLv4ovo9okiz4XTU-LDsRA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Children>
-                                <Parameter id="Jze4sNPHqEWpIAOToNE5sw" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                                <Parameter id="_1J7o1PSR0KGYT6NHUlRpA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_duo" visible="0" canBeVaried="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="DA5Q8LMHPk6_4MaWnOmKqQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule" />
-                      </Children>
-                    </Container>
-                    <Container id="0vAJFGRmwkGOEsw6EaIBJA" name="UpperJejunum" description="Upper Jejunum" icon="UpperJejunum" mode="Logical" containerType="Compartment">
-                      <Children>
-                        <Parameter id="JsuZKaKkDU60Dr81he8HHQ" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="Individual_PKSim.PARAM_Tissue_Weight" visible="0" canBeVaried="1" displayUnit="kg" />
-                        <Parameter id="2Qp3GjoRoEOx_Z7IwI-xQg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="MucosaVolume.VOLUME_MucosaUpperJejunum" visible="1" canBeVaried="1" displayUnit="l" />
-                        <Parameter id="B7FUTX8WQki2zp2Osnugkw" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Q_lymph_mucosa" visible="1" canBeVaried="1" displayUnit="l/min" />
-                        <Parameter id="KpiB5VatMkSwXdhxqSRd7Q" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="VascularEndoVolume.VOLUME_VascularEndo_uje" visible="1" canBeVaried="0" displayUnit="l" />
-                        <Parameter id="Fxr_DySdVUaaTIuomeNUsg" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_J_iso_Mucosa" visible="1" canBeVaried="1" displayUnit="l/min" />
-                        <Parameter id="uguK3gC3k02O6iWfF5mfkA" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Q_mucosa" visible="1" canBeVaried="1" displayUnit="l/min" />
-                        <Parameter id="s-4OGEdwNkmqDpPSZeUXkQ" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_f_cell" visible="1" canBeVaried="1" />
-                        <Parameter id="ERBvtV-EbkmDrQtOh2E5-A" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                        <Parameter id="ZcLLl-IxRUqKHZbqB-fBuw" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                        <Parameter id="9uPOlm8FGEye1li63M1hgw" name="Fraction mucosa" description="Mucosal fraction of regional intestinal tissue mass" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.26" />
-                        <Parameter id="hkh9fyWaKkCuKomRMGZkXA" name="Fraction of regional blood flow rate" description="Regional blood flow fraction supplying the mucosal tissue of the segment" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.219" />
-                        <Parameter id="iS3GR-jkk0WfW6pEdMpaig" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" visible="1" canBeVaried="1" value="1.53888888888889E-10" displayUnit="ml/min/N" />
-                        <Parameter id="sBS0EtYx60ucSG3rp39aEw" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.05" />
-                        <Parameter id="uzSHFCBwakeHWyayy8A_RA" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="4.5E-08" displayUnit="µm" />
-                        <Parameter id="b55VCnDTDEKcoAuyK58uJw" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="2.5E-07" displayUnit="µm" />
-                        <Parameter id="BT6a4cyBR0mEBCSSJ5pJDQ" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.06" />
-                        <Parameter id="WtnegC_TSEe3H71i4b269Q" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0487" />
-                        <Parameter id="Nus8nLoenEmVIHf8P1rKJw" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.13" />
-                        <Parameter id="GXnRUyHE-UCSXvbyePargg" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.08" />
-                        <Parameter id="YCXfCDPqCUCJbXQzCZM29A" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0163" />
-                        <Parameter id="4GM1qx9cpEKYRKN8mvrxQg" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.718" />
-                        <Parameter id="7-uPyE3kP0eCtlTjIY_WLQ" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.141" />
-                        <Parameter id="zk41rN_H30aUMuHAijDUQg" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-                        <Parameter id="ZkyyGWS4SUCAO_XGVW9WZw" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.8" />
-                        <Parameter id="lP5H2R1aNU2c87l9eBMW7A" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.158" />
-                        <Parameter id="X4TS2oGyxUK5OoF7o6Lb-A" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.35" />
-                        <Parameter id="NmRM_iikHkuWaxePICzYag" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0375" />
-                        <Parameter id="zgsMJ3kqzUC_4IoLgvpLuQ" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0483" />
-                        <Parameter id="MMqAeFniokaeAheo4K72_g" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0182" />
-                        <Parameter id="sDxuqpTCck6RWOQ-QO4aXA" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0124" />
-                        <Parameter id="kpZ24QtqPEWHwABtGA5Dtw" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.15" />
-                        <Parameter id="P00bpx5fv0q0zDayDn-uZQ" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.282" />
-                        <Parameter id="f531h2E2CUa2wqdE72YXwg" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.78" />
-                        <Parameter id="RimWMdDhNEiGSDIE0gpylA" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.456" />
-                        <Parameter id="et-spFTyXEyrZr1G62VHzA" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="2.41" />
-                        <Parameter id="5EVD08-gRUG4HrSO2xwMPA" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0035" />
-                        <Container id="BfP4xKdBX0SaUMpMCDXvbg" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Mucosa" />
-                            <Tag value="SmallIntestineSegment" />
-                            <Tag value="UpperJejunum" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="gk_CboN9nEyyg2f2QtONzw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="5D0ZznAW7k23mnIZ23DViA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                            <Container id="fmPMsojYfUO8SSFCVkDWMg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Children>
-                                <Parameter id="PsTlXLLTW0aWKm9Q9joVYA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" visible="0" canBeVaried="0" />
-                                <Parameter id="Yhxg_9rriU6HcpNKYSurXw" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="Ej30rRxCREi_lFbIacWhBg" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Mucosa" />
-                            <Tag value="SmallIntestineSegment" />
-                            <Tag value="UpperJejunum" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="G8A79QGSEkiRuFeX_ByQow" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="FgXSmeHeL0ON7Ujn8gkfig" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                            <Container id="KJxmenvpt0STLhV2zu97TQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Children>
-                                <Parameter id="JhF8NW4ND0-f8wwj7MnnRA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" visible="0" canBeVaried="0" />
-                                <Parameter id="9ilEWf_xcUGHhabck1r3eg" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="8WvqhUtcp0qq4H3YVSDE7w" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Mucosa" />
-                            <Tag value="SmallIntestineSegment" />
-                            <Tag value="UpperJejunum" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="YYLrrbDWJU6oLnVsUU78OQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="OuD4rBK-bUWaMsq6Ju_UIQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                            <Parameter id="32Z-T_inekWLbNd_I3FBhA" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_pH_INT" visible="1" canBeVaried="1" />
-                            <Container id="DntKkG2tYUiUFhFRrCOG2A" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Children>
-                                <Parameter id="LJfff5mIIU6PgKWM9tc8Bg" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                                <Parameter id="stu-H_I0jUuZJJ8x23lSEA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_uje" visible="0" canBeVaried="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="kUFeS_kjtUW66GnJH4ZzKg" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="IntestinalSecretionSource" />
-                            <Tag value="Mucosa" />
-                            <Tag value="SmallIntestineSegment" />
-                            <Tag value="UpperJejunum" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="bWzWjve92U6u6AHEilVxeQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="8uEKa3Rjs0WHA5TYeO0Uxg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                            <Parameter id="zIOoZes37EKd0Mzu56oJDA" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.3" />
-                            <Container id="8vxlqL2WhkyE8JzkpqxS8g" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Children>
-                                <Parameter id="iftTWyocfE2xa44EHBY3lQ" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                                <Parameter id="4O1e93bqQkq6qqQDLGJL5g" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_uje" visible="0" canBeVaried="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="LWdFv8tQa0-5udJdEqrA3Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule" />
-                      </Children>
-                    </Container>
-                    <Container id="1HEqWqwIcUSnaHNptxAm3A" name="LowerJejunum" description="Lower Jejunum" icon="LowerJejunum" mode="Logical" containerType="Compartment">
-                      <Children>
-                        <Parameter id="53DLJ5Ls6kSZEXYpdo2YxA" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="Individual_PKSim.PARAM_Tissue_Weight" visible="0" canBeVaried="1" displayUnit="kg" />
-                        <Parameter id="q59de6mDlk6No82LH81O0Q" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="MucosaVolume.VOLUME_MucosaLowerJejunum" visible="1" canBeVaried="1" displayUnit="l" />
-                        <Parameter id="YOJW4mCNuEm2sqnWyT0B9Q" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_J_iso_Mucosa" visible="1" canBeVaried="1" displayUnit="l/min" />
-                        <Parameter id="jtAotNt9ckG0jpKUr2CQlw" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Q_lymph_mucosa" visible="1" canBeVaried="1" displayUnit="l/min" />
-                        <Parameter id="kdy1LT8coE2bIt1_VI7Fww" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="VascularEndoVolume.VOLUME_VascularEndo_lje" visible="1" canBeVaried="0" displayUnit="l" />
-                        <Parameter id="HqCr482t8kWvsjWUs8wRBg" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Q_mucosa" visible="1" canBeVaried="1" displayUnit="l/min" />
-                        <Parameter id="BEc4gcrSx0i1NGcaT6_s2g" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_f_cell" visible="1" canBeVaried="1" />
-                        <Parameter id="FRS2bcCmM0qZzZPiufZDaQ" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                        <Parameter id="W-JiTsJZl02os9O6R-4B_g" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                        <Parameter id="AHzFVXoNrEKU_xXOMXFC1w" name="Fraction of regional blood flow rate" description="Regional blood flow fraction supplying the mucosal tissue of the segment" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.219" />
-                        <Parameter id="Kur6ujvNtkeOnd01UHpy3A" name="Fraction mucosa" description="Mucosal fraction of regional intestinal tissue mass" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.26" />
-                        <Parameter id="bW3iX_D1Vk2QDjlBGd4TIA" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="4.5E-08" displayUnit="µm" />
-                        <Parameter id="4w11HGUm4EuxXaHP9uuA5Q" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.05" />
-                        <Parameter id="ai47h2ZtY0uXHNXRPm10Uw" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" visible="1" canBeVaried="1" value="1.53888888888889E-10" displayUnit="ml/min/N" />
-                        <Parameter id="Tx8yA-yfDUK5REEiM9q_-Q" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="2.5E-07" displayUnit="µm" />
-                        <Parameter id="wfQwvIf4rkinq7B3-G_4Ug" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0487" />
-                        <Parameter id="_q3NTG7D2USJ1UEd1TO_ow" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.06" />
-                        <Parameter id="Wj6_Vid6z0CoyDz-7OwPDQ" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.13" />
-                        <Parameter id="b4GvM4CEgEm7SjNglma3gg" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0163" />
-                        <Parameter id="jTK_5lZzMUuLdDnsUkH_Hw" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.08" />
-                        <Parameter id="5o2Z4zpMqk-1zy8HGMDfDA" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.158" />
-                        <Parameter id="F__GDhv4-kCuhD8TPKHoRg" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.141" />
-                        <Parameter id="y390ccEjbkWj5G-4uQ30yg" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-                        <Parameter id="LLuJLl4pX0iGC9GltosPLQ" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.8" />
-                        <Parameter id="RjBv1hpuY0mh48xF_f95UQ" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.718" />
-                        <Parameter id="vAdOd6wY4EWVeaFYv3bklg" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.32" />
-                        <Parameter id="y-Y_tXkAZUmmH-v1C2c2Gw" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0483" />
-                        <Parameter id="3B9BDCrYwkObbLUiBJZ-FA" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0375" />
-                        <Parameter id="Q-eaQkixq0i3vDLkdKiHbg" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0182" />
-                        <Parameter id="qixQ-5M42UOOE3QdME3hQg" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0124" />
-                        <Parameter id="F2rU6OUx8ke5pTI1ubKTRA" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.282" />
-                        <Parameter id="rrvMj3Htx0ibEDJB2jR4iQ" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.15" />
-                        <Parameter id="uHZlhVZb9EO3dsdey4TiwA" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.456" />
-                        <Parameter id="eA1F4s6Htka5GLhL1mhjeQ" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.78" />
-                        <Parameter id="o4o9UgTZhUSFnO5wKfyGMQ" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0035" />
-                        <Parameter id="MSL3dqFyU0yBWfiGx6S_lA" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="2.41" />
-                        <Container id="1XxBZvONAEWWEWN1gOg4VQ" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="LowerJejunum" />
-                            <Tag value="Mucosa" />
-                            <Tag value="SmallIntestineSegment" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="xZtPiQZfVUCUpBFCY6Fpmg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="diETd5_XF0-p62De1tMYyQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                            <Container id="UTuSdVQU70qrO4EbW3S95Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Children>
-                                <Parameter id="gzmNWzAY0UazClf8eeS7hw" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                                <Parameter id="zyz3QJ6maUyOI8OV72WaOA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" visible="0" canBeVaried="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="JvhcU5G9sESOfI0HQ9iySg" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="LowerJejunum" />
-                            <Tag value="Mucosa" />
-                            <Tag value="SmallIntestineSegment" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="AffMYD6npE6s3VjHeetFrg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="nIjeMNq73U2JG5CU8p9tvg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                            <Container id="7nsxY2Z-1USb-iQIRzN0gw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Children>
-                                <Parameter id="P3jmHKdcA0mVtbxkcpHb9w" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                                <Parameter id="tGk9aX33eUaUG13J-N6EJg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" visible="0" canBeVaried="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="honL0CTkBUiLa6hPDJjRow" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="LowerJejunum" />
-                            <Tag value="Mucosa" />
-                            <Tag value="SmallIntestineSegment" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="vz9H4G8hSUKxBoxitm6J1g" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="Yad7tMmcakKayXpPk484zg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                            <Parameter id="PRH8HDULPkGR2X34h0dV9g" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_pH_INT" visible="1" canBeVaried="1" />
-                            <Container id="fAXzSc59r02-swH03Qja3Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Children>
-                                <Parameter id="-5BrZweOtU-gtFBpr6wXrA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_lje" visible="0" canBeVaried="0" />
-                                <Parameter id="ayS3xAMDIUSEa2bhGH0Vcg" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="H45QSpDHZU6_rrF8B6S3IQ" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="IntestinalSecretionSource" />
-                            <Tag value="LowerJejunum" />
-                            <Tag value="Mucosa" />
-                            <Tag value="SmallIntestineSegment" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="IP5nPiFI1EmfeWfp0SXrcg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="wIe9plonnki8OcH0EBnV0w" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                            <Parameter id="AsZKmN4fTkKKz06NgU2GqQ" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.3" />
-                            <Container id="BDFqk2qcwEurRHry2Uc7CQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Children>
-                                <Parameter id="XHqKAS83f0GVpyKfGdk3xg" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                                <Parameter id="E2C2MDQf3USagG2zCCpO1w" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_lje" visible="0" canBeVaried="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="JTPLA49GwUmoZRjD142Aqw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule" />
-                      </Children>
-                    </Container>
-                    <Container id="fyOwEYedkEeFH8S2n_n5hw" name="UpperIleum" description="Upper Ileum" icon="UpperIleum" mode="Logical" containerType="Compartment">
-                      <Children>
-                        <Parameter id="Ys7JrxXcLEWqsYJ3VYshng" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="Individual_PKSim.PARAM_Tissue_Weight" visible="0" canBeVaried="1" displayUnit="kg" />
-                        <Parameter id="7MviCuES8ESSYeIQaEtwvQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="MucosaVolume.VOLUME_MucosaUpperIleum" visible="1" canBeVaried="1" displayUnit="l" />
-                        <Parameter id="St8Fn15DJUClDcxA4ai6Fg" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_J_iso_Mucosa" visible="1" canBeVaried="1" displayUnit="l/min" />
-                        <Parameter id="0XPh23om3E2k58i9rOjRQg" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Q_lymph_mucosa" visible="1" canBeVaried="1" displayUnit="l/min" />
-                        <Parameter id="HoO4deZ1U0K2enuI-IizdQ" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="VascularEndoVolume.VOLUME_VascularEndo_uil" visible="1" canBeVaried="0" displayUnit="l" />
-                        <Parameter id="p-9qxigADU6C35Uq-2ngxQ" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Q_mucosa" visible="1" canBeVaried="1" displayUnit="l/min" />
-                        <Parameter id="djrZwbH-xEGXJqqSEhcOQw" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_f_cell" visible="1" canBeVaried="1" />
-                        <Parameter id="liZCvWoCIkeqc7XwQYHpqw" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                        <Parameter id="ImUsLbCPQUOKSLvZRvE-Mg" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                        <Parameter id="ODshviadd06syxwFYGEeEw" name="Fraction mucosa" description="Mucosal fraction of regional intestinal tissue mass" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.13" />
-                        <Parameter id="fLZiCZ_fl0Sol5UOnt-jGw" name="Fraction of regional blood flow rate" description="Regional blood flow fraction supplying the mucosal tissue of the segment" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.2345" />
-                        <Parameter id="MrR8QlWN00O6dW_BxZRD0g" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="2.5E-07" displayUnit="µm" />
-                        <Parameter id="JiDwIizDy0Wo0EhBg8joAg" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" visible="1" canBeVaried="1" value="1.53888888888889E-10" displayUnit="ml/min/N" />
-                        <Parameter id="4kNaspC7t0OoynSbCNgDPg" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.05" />
-                        <Parameter id="ikbFXSss3kOzI7I4Esmztw" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="4.5E-08" displayUnit="µm" />
-                        <Parameter id="IyeJkm2sqU-C9F7UuOEupw" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.06" />
-                        <Parameter id="ZrCLYo2xVE2YFHYvPkpSzQ" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0487" />
-                        <Parameter id="rEAwBpWYckyf891_HzDTBw" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.13" />
-                        <Parameter id="sDzWBZ7qekubaSfgV10csw" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.08" />
-                        <Parameter id="Ea8WUt4ckkyg1kgvzOzl7g" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0163" />
-                        <Parameter id="kyLZtovvwUuKwn6U8UdsAQ" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.8" />
-                        <Parameter id="v6o_hyuXPEKKhiN7AgD8rA" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.158" />
-                        <Parameter id="VJPUnZF67EGJPc7LFxuKSA" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.141" />
-                        <Parameter id="SlBrQcobVE6gIgnrXuZBcQ" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-                        <Parameter id="t5vt_B-SW0i6CBwsF4n4oQ" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.718" />
-                        <Parameter id="Awu-cBPQe0uqiRsDs5ODLQ" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.31" />
-                        <Parameter id="tH-erxKiK0m8hMNeQWxdjQ" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0483" />
-                        <Parameter id="AgLHEgDY9U6kIfDkVamTIg" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0375" />
-                        <Parameter id="4aPlxuSQEEGVFx9G38tdDw" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0124" />
-                        <Parameter id="zAx2igbYHUGS72Pdoxss_A" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0182" />
-                        <Parameter id="ubFuwpzgjkGEUe-zXP_i0A" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.282" />
-                        <Parameter id="_wICt8FZ80WDAKeumXRBoA" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.15" />
-                        <Parameter id="Qsu9I5Py5ECzzJpOhkO3Xw" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.78" />
-                        <Parameter id="-BhaNu6Qa0u_umiNePh42g" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.456" />
-                        <Parameter id="AMOhlCSVLU-8ccAZxehWgA" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0035" />
-                        <Parameter id="1W2FQmzRhEasGUqYudjHHQ" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="2.41" />
-                        <Container id="agEz-d8UnU2AlENh6qiY5A" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Mucosa" />
-                            <Tag value="SmallIntestineSegment" />
-                            <Tag value="UpperIleum" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="S9jVyWPqgE6xikF3csBKzg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="MeKof2Nh1EuxVVmc4QTohA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                            <Container id="O0JsKRUbGEed__yXClIMow" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Children>
-                                <Parameter id="PVYMfJEaJEaPpdNl0mgyfw" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                                <Parameter id="7nE5tnsiWEuDrcmGwVDIPw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" visible="0" canBeVaried="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="o2sI8fS0SkSgY4brbhcmyA" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Mucosa" />
-                            <Tag value="SmallIntestineSegment" />
-                            <Tag value="UpperIleum" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="c6St3lUDlkq-55Fg3g0MVw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="xM9LGc2CbkaV2nr6JiBbBw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                            <Container id="5lEcsnXyZUyMkgoWQBQXvg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Children>
-                                <Parameter id="60HlMeETh0yErFbLVVgYHg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" visible="0" canBeVaried="0" />
-                                <Parameter id="DsttZgjI2kqjObALs3IgsA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="VS_6r7J0k0WDnZVbs6ZemQ" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Mucosa" />
-                            <Tag value="SmallIntestineSegment" />
-                            <Tag value="UpperIleum" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="JLNkKgHnykOUP8a1sV1r8w" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="1rr3gLhsGEaC40CNfKJNbA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                            <Parameter id="Ets-HFNFkkqX69xHW8hTNA" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_pH_INT" visible="1" canBeVaried="1" />
-                            <Container id="MyZIqSsuoUuxtbwFux_uNQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Children>
-                                <Parameter id="e7pXpQbKcUmkQ65FQRxsQQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_uil" visible="0" canBeVaried="0" />
-                                <Parameter id="kFzqbMY9yUS4kHCNzRcLuA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="Ei9kUV8Ht0yP_sgNxLtolg" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="IntestinalSecretionSource" />
-                            <Tag value="Mucosa" />
-                            <Tag value="SmallIntestineSegment" />
-                            <Tag value="UpperIleum" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="rQlWILmi6kOcMrUFzP6bRQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="k5L0Gp-OXUSIoifoJiHf-Q" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                            <Parameter id="GhhSudIik0e5RcrIv3teAA" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.3" />
-                            <Container id="S2sd5ldlQEG_BfFtdChJBg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Children>
-                                <Parameter id="nJNmVMrLLUuD1NO4gyFNJQ" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                                <Parameter id="zWqLrwDNAkCqFEJR7TR3gA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_uil" visible="0" canBeVaried="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="-NIoVUlb606UB9rDwho6_w" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule" />
-                      </Children>
-                    </Container>
-                    <Container id="8nkimGq9FUmePzFz6Bfyjg" name="LowerIleum" description="Lower Ileum" icon="LowerIleum" mode="Logical" containerType="Compartment">
-                      <Children>
-                        <Parameter id="NorT6rowpUWB_nh2Tgl5xg" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="Individual_PKSim.PARAM_Tissue_Weight" visible="0" canBeVaried="1" displayUnit="kg" />
-                        <Parameter id="TcEgIeMpjkWZMB6ymRbaRA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="MucosaVolume.VOLUME_MucosaLowerIleum" visible="1" canBeVaried="1" displayUnit="l" />
-                        <Parameter id="57uuvIfetkGV2P9ja37jgA" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="VascularEndoVolume.VOLUME_VascularEndo_lil" visible="1" canBeVaried="0" displayUnit="l" />
-                        <Parameter id="A0fIxG1UpkeZrLbRzn7tbg" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Q_lymph_mucosa" visible="1" canBeVaried="1" displayUnit="l/min" />
-                        <Parameter id="s5LgHXHewUWcBWJaMsYBLg" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_J_iso_Mucosa" visible="1" canBeVaried="1" displayUnit="l/min" />
-                        <Parameter id="21tthNZtlE-GQFfG6m9SQw" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Q_mucosa" visible="1" canBeVaried="1" displayUnit="l/min" />
-                        <Parameter id="t-BcGFWcPkiDgPgSAtQU8w" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_f_cell" visible="1" canBeVaried="1" />
-                        <Parameter id="YJ8xXI4DvUedDTWkV9ngDA" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                        <Parameter id="n82TfxbuAk2zf2vETDLjBg" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                        <Parameter id="CnXi-VGXeEGD8otbxXaT-Q" name="Fraction mucosa" description="Mucosal fraction of regional intestinal tissue mass" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.13" />
-                        <Parameter id="A4PV2CU7H02Mh9Xi5HjNuA" name="Fraction of regional blood flow rate" description="Regional blood flow fraction supplying the mucosal tissue of the segment" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.2345" />
-                        <Parameter id="PQQAp9ZarE6kzAf9U7SH_w" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.05" />
-                        <Parameter id="XZhrsm1l_067P9uwXiWyHg" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="4.5E-08" displayUnit="µm" />
-                        <Parameter id="0khUddi0Xkm1InBNswFV5A" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" visible="1" canBeVaried="1" value="1.53888888888889E-10" displayUnit="ml/min/N" />
-                        <Parameter id="84rpml3AX0ynZr_997Ut5A" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="2.5E-07" displayUnit="µm" />
-                        <Parameter id="-6x6PcnMdE-YX_9KfLe3gA" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0487" />
-                        <Parameter id="yLmZVVROokWjAKnIVqKHVA" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.06" />
-                        <Parameter id="cOrDiGxoeUyqCl30EKYarQ" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.13" />
-                        <Parameter id="bb5oYubHYU2tXKHtWDCf4A" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0163" />
-                        <Parameter id="995hwoCQE0q_HVvBuuI2zg" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.08" />
-                        <Parameter id="mee-XJjYp0i_ZJfE_rGUhA" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.158" />
-                        <Parameter id="e3wp5CdhDEmofnN4Hji8GQ" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.141" />
-                        <Parameter id="x9VHgmod-kao4hoEwF5cGw" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-                        <Parameter id="slor9T3W_Ey14oj5Wc_NRA" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.718" />
-                        <Parameter id="tgg9cnGG_EqAZvTaXC8Scg" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.8" />
-                        <Parameter id="VJ6vS_qpskWAbb1K2VHxDw" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.32" />
-                        <Parameter id="8ll_dWUJr0Or4XQPEb5xAw" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0483" />
-                        <Parameter id="MriOIBP2HE2uW22whbFAEQ" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0375" />
-                        <Parameter id="wa0aFlTMAEOb3QDt_00oRw" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0124" />
-                        <Parameter id="-oB07_H0DkePVZ0AUAgCJA" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0182" />
-                        <Parameter id="5OTWlT_HvU-qkz1uuHO8ZA" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.15" />
-                        <Parameter id="TyAFrcbCY02Aiz_IJ70Alw" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.282" />
-                        <Parameter id="CsnjmQdUgEOpX0muxVcWxQ" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.456" />
-                        <Parameter id="qOeU5aiiZUOVJlzDotL3yg" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.78" />
-                        <Parameter id="GDcAK3XBREaeQX7fzHxSxA" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0035" />
-                        <Parameter id="Grj6i3A8L0SwgDkX2z78gA" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="2.41" />
-                        <Container id="SheBaQRntUS7Uq436niclQ" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="LowerIleum" />
-                            <Tag value="Mucosa" />
-                            <Tag value="SmallIntestineSegment" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="k4hc1Q4q6UuNlOUkjyfvUA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="umJGb6OZg0eqa5-hsI-Z5A" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                            <Container id="5ds58e1SuEqQh5nO5r39zw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Children>
-                                <Parameter id="Q9ONGw3hykaRAb4zbDm5Ig" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                                <Parameter id="w0nRNt3unkyquv5Tn9nrdQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" visible="0" canBeVaried="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="ziNIenMYrkK_Eu94Cg5BFQ" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="LowerIleum" />
-                            <Tag value="Mucosa" />
-                            <Tag value="SmallIntestineSegment" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="jArPjWoRrk2kAcFOedPovw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="QYKzUwMqak2vILugN7wPPQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                            <Container id="zBhzRx1rdEmozr4ZnnNI3Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Children>
-                                <Parameter id="sEqauZxTb0SiDLPKa8OZlQ" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                                <Parameter id="CxUhPcqLG0C40tBMGJbDAg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" visible="0" canBeVaried="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="lsB27MsEJE2VZfZQB7uX0Q" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="LowerIleum" />
-                            <Tag value="Mucosa" />
-                            <Tag value="SmallIntestineSegment" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="oa4RxVg9cU2jYdc1Y0b8iw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="mQ_0whfa9UWM5H4rchf-Kg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                            <Parameter id="IeM_E2O0iE2EK-CaHYauDw" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_pH_INT" visible="1" canBeVaried="1" />
-                            <Container id="heL8RP9RJEmQkx4hPOHkMA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Children>
-                                <Parameter id="0QelH9AekUqJV_GAbOa4jA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                                <Parameter id="qFyPM5MkZ02n5r4PmCB1qQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_lil" visible="0" canBeVaried="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="an9mtKGGd0m69RC9jFTrLA" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="IntestinalSecretionSource" />
-                            <Tag value="LowerIleum" />
-                            <Tag value="Mucosa" />
-                            <Tag value="SmallIntestineSegment" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="Cr2x9hSDL0u6r1wB1o7-Xg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="RYw2TJCgNU2R7lFaIpPE_g" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                            <Parameter id="k9qe6Md3vEWkDfg0l_pz0g" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.3" />
-                            <Container id="6NyPjJIYK0qDksHCB2Ulqw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Children>
-                                <Parameter id="-RTUX3rgxU2P6FIUionfJA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                                <Parameter id="tZZSVy55akKzwLNYG1E7Cw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_lil" visible="0" canBeVaried="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="lFFMwtt3bUyue0MxbUlyzg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-              </Children>
-            </Container>
-            <Container id="mS4jII2PikeoGXb-dohEjw" name="LargeIntestine" description="LargeIntestine" icon="LargeIntestine" mode="Logical" containerType="Organ">
-              <Tags>
-                <Tag value="Portal Vein Supplying Organ" />
-                <Tag value="TissueOrgan" />
-              </Tags>
-              <Children>
-                <Parameter id="98w9G6qoM0id6wscEo2xtg" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="Individual_PKSim.PARAM_Tissue_Weight" visible="0" canBeVaried="1" displayUnit="kg" />
-                <Parameter id="O548iR4Fg0u8g0u4J4JNkw" name="Volume (mucosa)" description="Volume of mucosa" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="MucosaVolume.VOLUME_LargeIntestineMucosa" visible="1" canBeVaried="1" displayUnit="l" />
-                <Parameter id="5JGsH90Ff0yWQpPOdjAhnQ" name="Large intestinal transit time factor" description="Large intestinal transit time factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Lumen_PKSim.PARAM_LITT_Factor" visible="0" canBeVaried="1" />
-                <Parameter id="MYd4CIYgdkCrWequFF_Rhg" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_FluidRecirculationRate_lin" visible="1" canBeVaried="0" displayUnit="l/min" />
-                <Parameter id="n2eRYHUpt0m7kPYKoUc7dg" name="Fluid recirculation flow rate (incl. mucosa)" description="Fluid recirculation flow rate between plasma and interstitial space (incl. mucosa)" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate_(incl._mucosa)_LargeIntestine" visible="1" canBeVaried="1" displayUnit="l/min" />
-                <Parameter id="EERu2Ukks0yI_jpsFx-ltw" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Q_Lymph_lin" visible="1" canBeVaried="0" displayUnit="l/min" />
-                <Parameter id="rvfmaI20bUSOfpR71gUE2w" name="Lymph flow rate (incl. mucosa)" description="Lymph flow rate (incl. mucosa)" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Lymph_flow_rate_(incl._mucosa)_LargeIntestine" visible="1" canBeVaried="1" displayUnit="l/min" />
-                <Parameter id="Osdxoz11AEG5zC4zscHmnQ" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="VascularEndoVolume.VOLUME_VascularEndo_lin" visible="1" canBeVaried="0" displayUnit="l" />
-                <Parameter id="lOUkcv9CvkKFtPCY6Gvg8w" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_f_cell" visible="1" canBeVaried="1" />
-                <Parameter id="zSGuNQa1BkG3Q6mzTvgNzQ" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Q_from_Qspec" visible="1" canBeVaried="1" displayUnit="l/min" />
-                <Parameter id="AJhsSPgIPkylkf8lJHb0qw" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                <Parameter id="Bv8h1UJiqEiv00Xh0HtwZA" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.75" />
-                <Parameter id="30RvddI3Pka5pBSLPkfWJw" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                <Parameter id="FcwnMXsxTE6PD3HIfdMlJw" name="Mucosa blood flow fraction" description="Blood fraction which goes to mucosa" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.75" />
-                <Parameter id="YxoAxLHngU6G4bsIaOz_gw" name="Large intestinal transit time factor slope" description="Large intestinal transit time factor slope" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" visible="0" canBeVaried="0" value="0.938" displayUnit="1/min" />
-                <Parameter id="MO_FcnN_u0imK4ymreulhA" name="Large intestinal transit time factor intercept" description="Large intestinal transit time factor intercept" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="0" value="47.6" />
-                <Parameter id="R_HodPT5Nkitzhvc6RyN_g" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="4.5E-08" displayUnit="µm" />
-                <Parameter id="GwAtHWBPykuj-KiqNnJTFQ" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="2.5E-07" displayUnit="µm" />
-                <Parameter id="Zlxwzz5S7EmdIfWpcFvASQ" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.05" />
-                <Parameter id="mxuY09HQaki6L-TD0qpuaw" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" visible="1" canBeVaried="1" value="1.86944444444444E-10" displayUnit="ml/min/N" />
-                <Parameter id="6fbl__y8C0WIyHfR9OYnPg" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.062" />
-                <Parameter id="0Y4MnJt9d0W8ZsflRnDiAw" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0487" />
-                <Parameter id="eW7bruglikOF0IojV2mGiA" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.024" />
-                <Parameter id="JvCNZ5ycAEeDxZJotMzcOw" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.133" />
-                <Parameter id="Gzt0d1y1IkKzzzRzWr1AdQ" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0163" />
-                <Parameter id="Llz-CcjHr0uLAVm_PvPMqw" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.141" />
-                <Parameter id="HHLvIR88TkGeHg85qbEKCQ" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.718" />
-                <Parameter id="61eFmX-BbE6F9Dl7c2Q92w" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.792" />
-                <Parameter id="FGbVx5fMHkSpRLGKOiDkFA" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.158" />
-                <Parameter id="KmGKcVOSrECMGtq5ldeZFw" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-                <Parameter id="4-RLuxZU6EikMOkaF6lz6Q" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.094" />
-                <Parameter id="1fcT9tnTbUuoi089Y8Iu-w" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0483" />
-                <Parameter id="qTM5ODDdeUaKtXHJAQiv3w" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0375" />
-                <Parameter id="oskOzGCeNEOb0I-A_mZQsQ" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0182" />
-                <Parameter id="JOTbmc_MzEaXF8zvHEqqyA" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0124" />
-                <Parameter id="SRR2FnMp9Uuox3VFhsEW7A" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.282" />
-                <Parameter id="pb1txZyZtkuI5muNlh110Q" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.15" />
-                <Parameter id="H5uiK1qOLE2FdImghOap8w" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.456" />
-                <Parameter id="YNPysvYOU0W5wbYQxm9SCA" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.78" />
-                <Parameter id="uW83vPCDXU6yQRIvx-31QQ" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="2.41" />
-                <Parameter id="c1nG7n1SgUipZwzXCqAqxg" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0035" />
-                <DistributedParameter id="z9lSF81FOUak6X5ykYn_Sg" name="Large intestinal transit time" description="The time required for the passage of a non-absorbable compound through the large intestine, defined as the time span between small intestinal transit (i.e. the point at which 90% of the drug mass has entered the caecum) and the time at which 70% is excreted into feces" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" formula="XD1C9LNZb0CvdfAlYarLYg" mode="Logical" visible="1" displayUnit="h">
-                  <Children>
-                    <Parameter id="9F0p0R5C8E21VbwxfRyonA" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" displayUnit="h" />
-                    <Parameter id="XxculACkEUG_Jc7f_SrbFg" name="Mean" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" visible="0" canBeVaried="1" value="2652" displayUnit="h" />
-                  </Children>
-                </DistributedParameter>
-                <DistributedParameter id="ilqP_wnnTkm9gKF4hYS3yg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="gX4XIQRAAE2eyN4lSRnq6Q" mode="Logical" visible="1" displayUnit="l">
-                  <Children>
-                    <Parameter id="Os1RDzXuMESciB6W92Jyfw" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.501896001506457" displayUnit="l" />
-                    <Parameter id="MVzT4-OanUehmCRH_BT24g" name="Mean" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" value="0.332056702440576" displayUnit="l" />
-                    <Parameter id="tKYs6wwQSkCAvKq1bR_qEw" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0649145074993143" displayUnit="l" />
-                  </Children>
-                </DistributedParameter>
-                <DistributedParameter id="yjixy6mOVkeLUPSC2XaaVw" name="Specific blood flow rate" description="Blood flow rate normalized to the organ volume" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" formula="z5l3SmEWzEyPYdw7almqCA" mode="Logical" visible="1" displayUnit="ml/min/100g organ">
-                  <Children>
-                    <Parameter id="vX79kZXF-UScEVAiBvgTQw" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" displayUnit="ml/min/100g organ" />
-                    <Parameter id="9tvyAqb-4kOPI0MY8owfZQ" name="Mean" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" visible="0" canBeVaried="1" value="0.6305" displayUnit="ml/min/100g organ" />
-                    <Parameter id="UJTtsQZlME6n1heIHVXfFw" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" visible="0" canBeVaried="1" value="0.031525" displayUnit="ml/min/100g organ" />
-                  </Children>
-                </DistributedParameter>
-                <Container id="pX3ccCxXKEyKOoR4QI5kRg" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="LargeIntestine" />
-                    <Tag value="Portal Vein Supplying Organ" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="0MwhLKZzhUC2z7ocAe-GuQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="KOQ8qC1EKkixEsjLvLv1gw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_pls_SinLin" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Container id="iEl240_g70m7UirbI_SmMA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Children>
-                        <Parameter id="kZKS3eJ0Ekqc7gr8OabRgA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" visible="0" canBeVaried="0" />
-                        <Parameter id="LxavEh2rmku7uarWM9jfHg" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="PHp1m9J9BUW9Wt4S_ZSJwQ" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="LargeIntestine" />
-                    <Tag value="Portal Vein Supplying Organ" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="jMbAso9x2Ee9Euh1M5t6iA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="mEBSTHVEv0eyhvq4t5H3bA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_bc_SinLin" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Container id="mDY5EWDkpUK4gikejvimKQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Children>
-                        <Parameter id="6ho6jsSKIUOuGC5K0KWaTA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                        <Parameter id="wTD3p13Le0OqaNverE7VGw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" visible="0" canBeVaried="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="0OwBcRx450qQxH3cgG_UQg" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="LargeIntestine" />
-                    <Tag value="Portal Vein Supplying Organ" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="h_bezEI7TE2RYc_DfZXaxw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="nTHMrM7GUkWb4UkmhWXFlw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_int_SinLin" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Parameter id="NvjGAiQmFEqxY6fjj7CubA" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_pH_INT" visible="1" canBeVaried="1" />
-                    <Container id="iatv-Aoun0GPD5vYFADxmQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Children>
-                        <Parameter id="egcYq8IUWEepIfIaYGWl0A" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                        <Parameter id="ui5XvT54IUargG_YFpMWrQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_lin" visible="0" canBeVaried="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="SsjWITg_cki0-Sl5N7Etww" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="LargeIntestine" />
-                    <Tag value="Portal Vein Supplying Organ" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="uHJl1ItlQEKiNo1suvRFSw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ_SinLin" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="e2199hclGUu3oVS4SDGiDQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_cell_SinLin" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Parameter id="KjNYpdM_Hke7G5ZnxELGVQ" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.4" />
-                    <Container id="rtDpXb1MD0W1ZbTR9UjxHw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Children>
-                        <Parameter id="rW71qmeJskuUp_8fC_G7HQ" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                        <Parameter id="rKAQIoAfxk-9iHjnRFcQ5w" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_lin" visible="0" canBeVaried="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="-Jv3PilFfEWy3Hjs3zu2EA" name="Mucosa" description="Mucosa" mode="Logical" containerType="Compartment">
-                  <Children>
-                    <Container id="0GK2BGRdNEOoZ697IgWg6w" name="Caecum" description="Cecum" icon="Caecum" mode="Logical" containerType="Compartment">
-                      <Children>
-                        <Parameter id="2CeoFt1HhEeoiUVKjDlOGw" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="Individual_PKSim.PARAM_Tissue_Weight" visible="0" canBeVaried="1" displayUnit="kg" />
-                        <Parameter id="lmmi4Nf5Ak6nnQlPueTd0g" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="MucosaVolume.VOLUME_MucosaCaecum" visible="1" canBeVaried="1" displayUnit="l" />
-                        <Parameter id="5bdzs1vNtEeF0ynLUP5utw" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="VascularEndoVolume.VOLUME_VascularEndo_cae" visible="1" canBeVaried="0" displayUnit="l" />
-                        <Parameter id="47MZpKpET0qRHYbIYsQSLQ" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_J_iso_Mucosa" visible="1" canBeVaried="1" displayUnit="l/min" />
-                        <Parameter id="SFYMNIV8vE6WXZMcVunoDw" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Q_lymph_mucosa" visible="1" canBeVaried="1" displayUnit="l/min" />
-                        <Parameter id="BR26U2Kwe0m-EknTgWONjg" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Q_mucosa" visible="1" canBeVaried="1" displayUnit="l/min" />
-                        <Parameter id="C0782oAvcUG2nhS3wYWdyQ" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_f_cell" visible="1" canBeVaried="1" />
-                        <Parameter id="4bIxpKqdjkaY8zsdX8t_RQ" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                        <Parameter id="JWIi24ABJUCTnP-X1G6vHQ" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                        <Parameter id="7tmjF5NTXE6UzkMGZUApsw" name="Fraction of regional blood flow rate" description="Regional blood flow fraction supplying the mucosal tissue of the segment" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.084706" />
-                        <Parameter id="IcQ-ZiksJ0yepo-sjaCNIQ" name="Fraction mucosa" description="Mucosal fraction of regional intestinal tissue mass" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.19" />
-                        <Parameter id="UZyGN7sZa0yzjKmhxJtnNw" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="4.5E-08" displayUnit="µm" />
-                        <Parameter id="I-nAKjZChE2_kooJ5usRHw" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.05" />
-                        <Parameter id="OhT8iZzBK0ecreu1-dPVYA" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="2.5E-07" displayUnit="µm" />
-                        <Parameter id="dfIer4FLqEGxheTqmg24gQ" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" visible="1" canBeVaried="1" value="1.86944444444444E-10" displayUnit="ml/min/N" />
-                        <Parameter id="1aTuJNj-9kaeUNCSPznQSg" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0487" />
-                        <Parameter id="BKhtmcHtFEyLFNcGEo4EWg" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.06" />
-                        <Parameter id="cV1LKJMylUS1g2gORRApng" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.13" />
-                        <Parameter id="maOGzU8zZUiysBKhi0HfyQ" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.08" />
-                        <Parameter id="xraWmJnwwEmtJtOIlBLnuA" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0163" />
-                        <Parameter id="8LqK_ePTXEO8egvlGShWOg" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.718" />
-                        <Parameter id="7Gs3zea45k6gtyk4gzjy4Q" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.141" />
-                        <Parameter id="BmFPpdN6SkirVHc73A0BWg" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.8" />
-                        <Parameter id="k4dI4ey-G0eUfFNuWDX4Pg" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.158" />
-                        <Parameter id="h_DN9rLT0kiGwoBAaMebSA" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-                        <Parameter id="VwOT9eDvQ02wj0VZg6LneQ" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.73" />
-                        <Parameter id="W_qtV6botk20-LDCJxttgg" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0483" />
-                        <Parameter id="c7LBq8v7WEqBLztnlBmK4A" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0375" />
-                        <Parameter id="dhTrIVfwbUyZQZVwFzBrsA" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0124" />
-                        <Parameter id="-dEpLQHuDki46Y-Qe8VeJg" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0182" />
-                        <Parameter id="cR3yslGTz0uvd2SnHV0nbw" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.282" />
-                        <Parameter id="AaGPz0ItC0qmGPER82p7Tw" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.15" />
-                        <Parameter id="kKXsa5uelEW8Nb3niwS7eA" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.456" />
-                        <Parameter id="k8fPr5NAz0-aX-M3xVHnZw" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.78" />
-                        <Parameter id="5o3y8BSI6EqtqFxv_p9FqQ" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0035" />
-                        <Parameter id="yRwZxhgs_kuKoTIsaUcRXw" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="2.41" />
-                        <Container id="LGbzLR1sNEiVJUOKeIrgIw" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Caecum" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="EITMXmZhFkOsqT6o_N2P7g" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="vmteF8AZJ0SnRl6UPM8ALA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                            <Container id="aO8OrFGNbEyoxE9uvZJwaQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Children>
-                                <Parameter id="M3_x6VWK30qauvwn8ASVpA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                                <Parameter id="EgPq10wu70qRM0pq8RVuBg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" visible="0" canBeVaried="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="aBn4kASOREa7YsOFIEj5NA" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Caecum" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="16KaaLQwp0-hH-L5CCPxlA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="DWBhMlPD_0etLG48DVoKlQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                            <Container id="mMcYGFeRGU2ZN4l7m5Ns9w" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Children>
-                                <Parameter id="fFMCYdgZeU-zvss8ITvdoA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                                <Parameter id="m-ldURgK-0GFyH0Nyray4Q" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" visible="0" canBeVaried="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="8TogfNoTa0-5OdFn8m3ejg" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Caecum" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="-HgJQH91506eL3e1UbuIUQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="qCxUraitY06r2RRmJBwAtg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                            <Parameter id="dqUqRLKiWE2b50ygTzV9UA" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_pH_INT" visible="1" canBeVaried="1" />
-                            <Container id="GpH6I4cfPUa8OF_IQYOAFw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Children>
-                                <Parameter id="9jNmsJu3fEOZPzY-J1cg3g" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                                <Parameter id="4FFU2QRlckCiwHxwSBAfeg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_cae" visible="0" canBeVaried="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="Joj-umseKkiu2xQHcZDCWA" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Caecum" />
-                            <Tag value="IntestinalSecretionSource" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="BVcZAgUWnEm5vk3xPtweXA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="9aOzDGiBPk6tqI30UzBB1A" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                            <Parameter id="IRD0MVZVqEiv6o9BHSOckQ" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.3" />
-                            <Container id="qN5GxrLmX0qkdepvpHHoHQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Children>
-                                <Parameter id="8Jppaa1wMU-rIdd35WptkQ" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                                <Parameter id="1TFHkP8Xe06PWmmJ6AvSbg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_cae" visible="0" canBeVaried="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="21RvZp9XT0W3h7Oew41etw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule" />
-                      </Children>
-                    </Container>
-                    <Container id="AMHwx5KWXkaMND3mJEQGwg" name="ColonAscendens" description="Colon Ascendens" icon="ColonAscendens" mode="Logical" containerType="Compartment">
-                      <Children>
-                        <Parameter id="P3sji8CQ10aBI4L665NmQg" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="Individual_PKSim.PARAM_Tissue_Weight" visible="0" canBeVaried="1" displayUnit="kg" />
-                        <Parameter id="MlcUnChDy0-QR_opopvqPA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="MucosaVolume.VOLUME_MucosaColonAscendens" visible="1" canBeVaried="1" displayUnit="l" />
-                        <Parameter id="bv1AyK3AB0ajZA8rzpBMUw" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="VascularEndoVolume.VOLUME_VascularEndo_colasc" visible="1" canBeVaried="0" displayUnit="l" />
-                        <Parameter id="x9oaqN-5iEGQ5Ux_booUVg" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_J_iso_Mucosa" visible="1" canBeVaried="1" displayUnit="l/min" />
-                        <Parameter id="XjNFCX8T10mq6lJX7EdmJg" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Q_lymph_mucosa" visible="1" canBeVaried="1" displayUnit="l/min" />
-                        <Parameter id="35WecJ3tB0GSb7oN-78xTA" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Q_mucosa" visible="1" canBeVaried="1" displayUnit="l/min" />
-                        <Parameter id="TGHHjfPMlUeIz0B2zW_HYg" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_f_cell" visible="1" canBeVaried="1" />
-                        <Parameter id="JlgCXxwTbUamRVbKO9US4w" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                        <Parameter id="pLucVGRS2EaHMMGZHbiP4w" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                        <Parameter id="Ei0NK20lQUyeuGx5y-YgGg" name="Fraction mucosa" description="Mucosal fraction of regional intestinal tissue mass" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.19" />
-                        <Parameter id="NVi4gAj_O0yYQEOvXdzitw" name="Fraction of regional blood flow rate" description="Regional blood flow fraction supplying the mucosal tissue of the segment" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.15529" />
-                        <Parameter id="ib3CanAzIkeNWS9dbw86MA" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="4.5E-08" displayUnit="µm" />
-                        <Parameter id="FN1ZYLl9cE2SwjSGh5oZqA" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="2.5E-07" displayUnit="µm" />
-                        <Parameter id="m-KokNKZa06VtCmftmTdeQ" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" visible="1" canBeVaried="1" value="1.86944444444444E-10" displayUnit="ml/min/N" />
-                        <Parameter id="-_oPdHGsOkKxEsImZ3RKYg" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.05" />
-                        <Parameter id="4FtssbZFnkuWvoLdh9BFQA" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.06" />
-                        <Parameter id="t_Gp68Fn6U6wHNJc8qv8ug" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0487" />
-                        <Parameter id="Xdrfd1EyR0y34gUi1Yzs1w" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.13" />
-                        <Parameter id="5lViNoQzn0aEPaX5-Cq6BQ" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.08" />
-                        <Parameter id="76GNGupQaUi54BY9eEVPqA" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0163" />
-                        <Parameter id="30bzc70ZE0WUfkHCuN6dQQ" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.141" />
-                        <Parameter id="JEux6Eaf2kWwxrGgbt000g" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.158" />
-                        <Parameter id="3xZyRsy_yUSgx8HmHU1h5Q" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-                        <Parameter id="2nZW6VD5d06UUrgrWtS7vg" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.718" />
-                        <Parameter id="Ih2NQQm4l02H9g4utLla2Q" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.8" />
-                        <Parameter id="9HwiP1cOnky12jkOvMhitQ" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.73" />
-                        <Parameter id="QPBgXEhDX0-ZEa6lmB5nWw" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0483" />
-                        <Parameter id="wphiu-mKZUurHI7I_z3cyw" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0375" />
-                        <Parameter id="l98OUgMvd0S4VaDKTen7ow" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0182" />
-                        <Parameter id="gGwhEnFDeUWNWuXgZ0XVwQ" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0124" />
-                        <Parameter id="kDP_3LJuok-WBH5YWCyWdg" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.15" />
-                        <Parameter id="MlI0_3zY1kCVVHieJZMvpA" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.282" />
-                        <Parameter id="fjOAja4AKUilsNVMds_EvA" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.456" />
-                        <Parameter id="omScPGpOzk-ktgH2OknmXg" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.78" />
-                        <Parameter id="OimXP6NVlk6WTfAtemKEDA" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="2.41" />
-                        <Parameter id="x8TDgiaDXEejMQAFVS9EHg" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0035" />
-                        <Container id="xNTwHCGTLkad12dHF4Jv1g" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="ColonAscendens" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="X1-D0dqfCEGc3AvJMD96tQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="i9EvJ3NsVEmbwHeVEdJcgA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                            <Container id="g4FHO3kAdkq0VaPUChqJpw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Children>
-                                <Parameter id="4mTcOuaavE23QBOvV619FA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" visible="0" canBeVaried="0" />
-                                <Parameter id="sPezkqHC6EewTuAkS3MHgw" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="TJ7QlIu16kuyvAuW5cJlaA" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="ColonAscendens" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="HWHR1-n3WkqJO1thiFwsfg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="mgsGJlOnIEmNLP8PKwDFow" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                            <Container id="Fgmna997BUe9W1_ODBkpQg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Children>
-                                <Parameter id="MCNrlDElnkO8xYNsbKwVbw" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                                <Parameter id="lIDsFstzAEyb9W5gRVKRfw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" visible="0" canBeVaried="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="NYmmlsqIWU-FZ3jqfSTfNg" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="ColonAscendens" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="TiWpL1Xm206FmtYvuts8Hw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="P3j6Iv7ba0WxqH-8EvwpQA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                            <Parameter id="K7hX26aUTE2pupvTqbqclw" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_pH_INT" visible="1" canBeVaried="1" />
-                            <Container id="iGKTWYLC-0qVDHLsBN0oXg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Children>
-                                <Parameter id="bqYmKl2v5EqAmq5vC9PwMQ" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                                <Parameter id="45RE30ThDEO9vSiPiqMqgA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_colasc" visible="0" canBeVaried="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="_1aapd_LZk-snh-NLRJiBg" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="ColonAscendens" />
-                            <Tag value="IntestinalSecretionSource" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="ZgiOT4ATNkOZWLqz8DBjdg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="WOXENuU480WsktK0zIwiVw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                            <Parameter id="MhWukXYsCUaCu2UubwxxlA" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.3" />
-                            <Container id="UqmCWC5e6k2-9ygavWyFkw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Children>
-                                <Parameter id="Pdi3paFV5ESNVrBXYNOlYQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_colasc" visible="0" canBeVaried="0" />
-                                <Parameter id="lOLaBWIzEkuESlHKv-XLiw" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="YpFLOo24U0yvHyKV5AaX2Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule" />
-                      </Children>
-                    </Container>
-                    <Container id="Hags3qjWSUedws7cHYz6Rg" name="ColonTransversum" description="Colon Transversum" icon="ColonTransversum" mode="Logical" containerType="Compartment">
-                      <Children>
-                        <Parameter id="RsM4l3nQrUasWPMWazP3wQ" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="Individual_PKSim.PARAM_Tissue_Weight" visible="0" canBeVaried="1" displayUnit="kg" />
-                        <Parameter id="yGGYSwg16kqYJ8WJF6mepQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="MucosaVolume.VOLUME_MucosaColonTransversum" visible="1" canBeVaried="1" displayUnit="l" />
-                        <Parameter id="cbVmyvnQqUiIFLEL8IRIew" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="VascularEndoVolume.VOLUME_VascularEndo_coltrans" visible="1" canBeVaried="0" displayUnit="l" />
-                        <Parameter id="miCsh8q-HEyIzOGftjoWaw" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Q_lymph_mucosa" visible="1" canBeVaried="1" displayUnit="l/min" />
-                        <Parameter id="ZdG1viejzkm4LDpIKexbgQ" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_J_iso_Mucosa" visible="1" canBeVaried="1" displayUnit="l/min" />
-                        <Parameter id="40mqwU-UTk-qIW6o6tNRFA" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Q_mucosa" visible="1" canBeVaried="1" displayUnit="l/min" />
-                        <Parameter id="3u0AI4TkkEesnEiqc5Qsfw" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_f_cell" visible="1" canBeVaried="1" />
-                        <Parameter id="pAAx5fX9hkSns4SQ65tFsg" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                        <Parameter id="RRDwsc6URkCXYWMR-I_jXg" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                        <Parameter id="Xwm9EBxkbUOKeqFE-XlAXw" name="Fraction of regional blood flow rate" description="Regional blood flow fraction supplying the mucosal tissue of the segment" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.32" />
-                        <Parameter id="LGFiFw7ro0WSeK12RXbBRg" name="Fraction mucosa" description="Mucosal fraction of regional intestinal tissue mass" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.21" />
-                        <Parameter id="hNBFCIZLokKuSDFB7dATIQ" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="4.5E-08" displayUnit="µm" />
-                        <Parameter id="_m_quBn2k0OGw2TLFGrJwQ" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="2.5E-07" displayUnit="µm" />
-                        <Parameter id="QYqhO4Ixzkmw75lr3xnYcw" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" visible="1" canBeVaried="1" value="1.86944444444444E-10" displayUnit="ml/min/N" />
-                        <Parameter id="diaGWmMaM02bE8iIHujhFg" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.05" />
-                        <Parameter id="HgOJ-XK8BUWAMsXShBZ7Xw" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.06" />
-                        <Parameter id="6MarSLBzbUiVygBx_4dpJA" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0487" />
-                        <Parameter id="IVv09N66K0mI54d4HMH14Q" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.12" />
-                        <Parameter id="_ojXQWFqL0-v2vqNaG3r6g" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0163" />
-                        <Parameter id="J88ull2eqUmGYoAoCIvz4Q" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.08" />
-                        <Parameter id="ChwqKGesTESviSqH9QgFhQ" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.158" />
-                        <Parameter id="od6UMA8Eoka7yqAArqeG3Q" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.718" />
-                        <Parameter id="si3NwQEk_kST4L2czcCGYA" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.8" />
-                        <Parameter id="BSHZXxXsh0GON96g4riJng" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-                        <Parameter id="DyIYDUJPPEei377uGPaD8w" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.141" />
-                        <Parameter id="CgnSvSg0Y0KsbipGy9yZ9g" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.74" />
-                        <Parameter id="CbSUUJ8310-rOQeesqssPQ" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0483" />
-                        <Parameter id="45vWeTbI_UupNFWobOKpPA" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0375" />
-                        <Parameter id="LYeKwLDD2EGJx6pMX50qFA" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0182" />
-                        <Parameter id="x4NIrER9vke-R0eaOnT4PQ" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0124" />
-                        <Parameter id="IRAU_zdh4Eu9pwvi2Z6j9A" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.282" />
-                        <Parameter id="IYohDac0_E6CHcP8aXJD2g" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.15" />
-                        <Parameter id="-K2jbDKSp0mrjLmn0CVgjw" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.456" />
-                        <Parameter id="AOiYpqRb0kqm1o9cqJsp7g" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.78" />
-                        <Parameter id="PmeIn9HkH0erJFWRT6nVEQ" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="2.41" />
-                        <Parameter id="dOUqkwdlBkuNcMCT0jZ0Xg" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0035" />
-                        <Container id="E3rvws_AOU-R8ZjRsJ7YJQ" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="ColonTransversum" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="3zHiQJND7kCVX4vO4Ao5FA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="Dq9ET-_1xk2tvtWVoKZhig" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                            <Container id="npX-50LcDEWkbBppr4ZGqA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Children>
-                                <Parameter id="4BSQ-VKKTE67EbFskhOUMA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" visible="0" canBeVaried="0" />
-                                <Parameter id="lOaZOcY9B0-4fhiYs3PUEQ" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="tHA3JFaL-U-G9uaHbdHBSg" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="ColonTransversum" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="lVU_QEYDKEWhiWaJ0ULMUw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="s8slA9HHSkK_le09XPe90Q" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                            <Container id="3BTPuM6vA0qteXdJNzuBAQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Children>
-                                <Parameter id="RsOJHcCbgE2Nzt3Gwr6nVQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" visible="0" canBeVaried="0" />
-                                <Parameter id="Jv9eP1Ev7kiVUzs9pxBBCA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="OSCX1Pbj-0qKg7UUO5RmPA" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="ColonTransversum" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="bvhnZ7ztjUm83HJG8s_m6g" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="Sv3sxE-ICEWSMqsInKY7Kg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                            <Parameter id="siCg_3IaukyjdTtBPn2ARg" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_pH_INT" visible="1" canBeVaried="1" />
-                            <Container id="WDvb-wHkpkOhLCCA1I9QEg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Children>
-                                <Parameter id="11u9t_wEb0CwFHTpfpQ-rw" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                                <Parameter id="zilGpFOrVUi0uQnY-6OxCA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_coltrans" visible="0" canBeVaried="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="VqzvPjlpO0OJvXYdR5m-rA" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="ColonTransversum" />
-                            <Tag value="IntestinalSecretionSource" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="EaCpBMbJ5EGSYHucY8LIfQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="ZtkkJ_Ns0U2cXBUH0SFDHQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                            <Parameter id="3pdS9MwjWE-0RZnS_DYX_Q" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.3" />
-                            <Container id="cuYHoKuAWkC6k8R7m5YAWQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Children>
-                                <Parameter id="3JzH4MpaBE2VkhCO9-uEIA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                                <Parameter id="Vpr7EB0PJ0WNKQ0u_TLlSg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_coltrans" visible="0" canBeVaried="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="_nRXkpVsS0WTQ0JX2FwQxg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule" />
-                      </Children>
-                    </Container>
-                    <Container id="VKMppHKTeEqe51szZA0h_A" name="ColonDescendens" description="Colon Descendens / Distal Colon 1" icon="ColonDescendens" mode="Logical" containerType="Compartment">
-                      <Children>
-                        <Parameter id="rJpwwUFxCEe3qw2ereWLqQ" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="Individual_PKSim.PARAM_Tissue_Weight" visible="0" canBeVaried="1" displayUnit="kg" />
-                        <Parameter id="pntfbEORKUS3IJDPuzPXoQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="MucosaVolume.VOLUME_MucosaColonDescendens" visible="1" canBeVaried="1" displayUnit="l" />
-                        <Parameter id="5BZ9QrMskE2dFQtnK4uMPQ" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_J_iso_Mucosa" visible="1" canBeVaried="1" displayUnit="l/min" />
-                        <Parameter id="ZsEHQGW8vEmRQUwwfJY2gA" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Q_lymph_mucosa" visible="1" canBeVaried="1" displayUnit="l/min" />
-                        <Parameter id="o20CB3m0jUO7Y1r9QoSqQA" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="VascularEndoVolume.VOLUME_VascularEndo_coldesc" visible="1" canBeVaried="0" displayUnit="l" />
-                        <Parameter id="VirOrq12yE6eYPnYewfQaQ" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Q_mucosa" visible="1" canBeVaried="1" displayUnit="l/min" />
-                        <Parameter id="duQSZ152hkG11Ke0bbBwQg" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_f_cell" visible="1" canBeVaried="1" />
-                        <Parameter id="AHafxtRkMEyQJhAoIBJFHg" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                        <Parameter id="b56y-rbIdE2KL_IuPbA8Yg" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                        <Parameter id="lmfLFqT97UiGID7ylRbE0g" name="Fraction mucosa" description="Mucosal fraction of regional intestinal tissue mass" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.14" />
-                        <Parameter id="ZK0xt4BcgEaCm4Vy6QnIHw" name="Fraction of regional blood flow rate" description="Regional blood flow fraction supplying the mucosal tissue of the segment" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.24" />
-                        <Parameter id="0EsCBPvT60C1orlAfo57-A" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="4.5E-08" displayUnit="µm" />
-                        <Parameter id="i5TVrqBoMky4AAmoLVSvjg" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="2.5E-07" displayUnit="µm" />
-                        <Parameter id="WK9qAfpDJkOJETLCNR0XnQ" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" visible="1" canBeVaried="1" value="1.86944444444444E-10" displayUnit="ml/min/N" />
-                        <Parameter id="r44dKHowWE-WZeSnZbBf8w" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.05" />
-                        <Parameter id="NRiknCNbfESToJQ6AdDBBA" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0487" />
-                        <Parameter id="uUbecz8ZPEGrr3sdKXxXiw" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.06" />
-                        <Parameter id="0lDuMAq8bE6Shabo0hHuGA" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.12" />
-                        <Parameter id="JiEYYmd7skm00TzAB8K2ig" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.08" />
-                        <Parameter id="XIOn2u66OUWrrxiFqTV9Qg" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0163" />
-                        <Parameter id="vnWxjjXJwE6yqkyUsACDPA" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.158" />
-                        <Parameter id="9nDn5w9DSUq_rQAzhsbMWw" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-                        <Parameter id="g8thhyMm-EOTiMBdYDRW3A" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.141" />
-                        <Parameter id="c8ro-DmE_EGfMRx_EI4EKQ" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.8" />
-                        <Parameter id="wG_pGP89e0aGJcA5Sa4zMA" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.718" />
-                        <Parameter id="b7VkQu4Tx0eeuJp1Ymeukw" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.74" />
-                        <Parameter id="qB50hVZ6t0Gd4p_2hX9SRA" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0375" />
-                        <Parameter id="5ytv9scbdkmhyLPY-7_nog" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0483" />
-                        <Parameter id="R98tkqdHd0Scwm3vMZWJIQ" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0182" />
-                        <Parameter id="xtjOC5FUNkazT1NyX9GIqg" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0124" />
-                        <Parameter id="J1IpFH6eQUOd_aJxqVHmJA" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.15" />
-                        <Parameter id="aQHxZtVlokOeQqBQy3FXfw" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.282" />
-                        <Parameter id="V4bCIDKbTkGqV9zZ50_wyQ" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.78" />
-                        <Parameter id="rTCB5k5JXEqdjK0cine2Ww" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.456" />
-                        <Parameter id="UV0blqNeyEOmLqyoOZl6VQ" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0035" />
-                        <Parameter id="RrqrpUvRwUKKDL_bZ4HUcA" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="2.41" />
-                        <Container id="xjPErKtgLE2tSY7-piU_pw" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="ColonDescendens" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="eCA8M25IDkOIzaDo-uOqcw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="ktFsbLMZO0io9KxzNfFaLg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                            <Container id="UcqVIDIqYEqou1qsFHb7UQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Children>
-                                <Parameter id="waHkbaIoOkGzY_rSHempTA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" visible="0" canBeVaried="0" />
-                                <Parameter id="e7_2N7bsK0eFLD4hjYEcRA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="wT5qkJMuWE6Wx6caeYjFJQ" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="ColonDescendens" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="pGgGolxC9kC0CIJY-Xxm0Q" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="d7goOjo2fkefPg_Z5PqXMg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                            <Container id="aEQs6Hk7rUGVTuKNmF8WxA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Children>
-                                <Parameter id="lUbF2aDPeEaZH9YjJmMW9Q" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                                <Parameter id="dSpb0ozYqEyw4tcgymGRpg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" visible="0" canBeVaried="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="UB8UfObHaEKIJ6imuRVB1g" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="ColonDescendens" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="UkmRemR1h0Cv12qLdIRWGA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="NNNyp2Fe-Um7WGLQRKjSWA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                            <Parameter id="ns3jlxnjFk-nnYTw_aGC7A" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_pH_INT" visible="1" canBeVaried="1" />
-                            <Container id="zlPG2gBiGkSyI7w57UNJEw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Children>
-                                <Parameter id="IiXlVQelo0-s39hKw2w63w" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                                <Parameter id="n05gXMSbSEidA6wA26Dl7Q" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_coldesc" visible="0" canBeVaried="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="C0gcpQDNPEiXPW_bEXT9ig" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="ColonDescendens" />
-                            <Tag value="IntestinalSecretionSource" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="4Z5WBbQrvUeZuSMfigUofQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="6He4Osm8Tki4dHzK6hnKfA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                            <Parameter id="LtXOhSN8I0Oe0AcKJwbsvA" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.3" />
-                            <Container id="F3jGmowtRUy_yhXdtWm49w" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Children>
-                                <Parameter id="_eNAC0aP90aOpMyMYcYdoA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                                <Parameter id="ww_7fHIuCkysbNxEqYTPGg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_coldesc" visible="0" canBeVaried="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="BHDry8HTx0-cg9TpvvX7Sw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule" />
-                      </Children>
-                    </Container>
-                    <Container id="cYeHFKt_XUqY6MLu-xf2_A" name="ColonSigmoid" description="Colon Sigmoid / Distal Colon 2" icon="ColonSigmoid" mode="Logical" containerType="Compartment">
-                      <Children>
-                        <Parameter id="aBAM574ZNUC5PshAasw_mQ" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="Individual_PKSim.PARAM_Tissue_Weight" visible="0" canBeVaried="1" displayUnit="kg" />
-                        <Parameter id="UrmVIzmAjk-3tW2SWykN3w" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="MucosaVolume.VOLUME_MucosaColonSigmoid" visible="1" canBeVaried="1" displayUnit="l" />
-                        <Parameter id="VXwN8MPQ10WgMK6WrvETuw" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_J_iso_Mucosa" visible="1" canBeVaried="1" displayUnit="l/min" />
-                        <Parameter id="UYMHUqt460GaVjmHKlBvRQ" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Q_lymph_mucosa" visible="1" canBeVaried="1" displayUnit="l/min" />
-                        <Parameter id="gMTgCxj9J0uucRHF9nlhUQ" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="VascularEndoVolume.VOLUME_VascularEndo_colsigm" visible="1" canBeVaried="0" displayUnit="l" />
-                        <Parameter id="6gn_vGKhOUuB6eAPLG8WuQ" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Q_mucosa" visible="1" canBeVaried="1" displayUnit="l/min" />
-                        <Parameter id="NzXN3pxagkSen9KYJN2jKg" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_f_cell" visible="1" canBeVaried="1" />
-                        <Parameter id="ASs2Av35QEC2XE3ZmAwozw" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                        <Parameter id="MyTPmK-nEE-GKyPkjTYOuQ" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                        <Parameter id="Cm4MCNyRAEG4TW8keBWnLQ" name="Fraction of regional blood flow rate" description="Regional blood flow fraction supplying the mucosal tissue of the segment" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.135" />
-                        <Parameter id="djhvTR2nM0Gcm6qBBPq5OQ" name="Fraction mucosa" description="Mucosal fraction of regional intestinal tissue mass" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.3" />
-                        <Parameter id="N2gpc53qnUa-cWsrE8Drqg" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="4.5E-08" displayUnit="µm" />
-                        <Parameter id="2JfchczbqkaT6_thAHcMFQ" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="2.5E-07" displayUnit="µm" />
-                        <Parameter id="bGLsNK_MZkixZoKJKCi3dg" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.05" />
-                        <Parameter id="56Y07gqhaEqgbGAyytGf4A" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" visible="1" canBeVaried="1" value="1.86944444444444E-10" displayUnit="ml/min/N" />
-                        <Parameter id="LXhVESRmrUub77IRqfy6_w" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0487" />
-                        <Parameter id="aOYPdgMqAk-G0xfJLVEzYQ" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.06" />
-                        <Parameter id="0fruJDetEUC1NEN_cZpoSA" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.08" />
-                        <Parameter id="Mkt1fXsEe0aKVQfyLUH6Zw" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0163" />
-                        <Parameter id="qY6m1yfo4EyTyMZ-ys7IQQ" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.08" />
-                        <Parameter id="t-Bakz_ogEiC96Gkqb3bkQ" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.8" />
-                        <Parameter id="Iyy0_fpvCU--xnmNkX0B1g" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.141" />
-                        <Parameter id="_Dhs5RHzY0KvMRiVdhWRdQ" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.158" />
-                        <Parameter id="xRDlSVkhp06ynZGOOdu5aw" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-                        <Parameter id="J-XHUON6N06j_h-RPTwOGQ" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.718" />
-                        <Parameter id="JSWd5IP0EUmk36jvspzkJQ" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.78" />
-                        <Parameter id="FeZnOjKqTkuJF-4YcTaRgg" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0483" />
-                        <Parameter id="SghE4vzdVESg4JJ8gjm_DA" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0375" />
-                        <Parameter id="lmck_gxqUkSkp5yCIdRF3Q" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0124" />
-                        <Parameter id="FFxQfUp0hUi_8HCrNFa04w" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0182" />
-                        <Parameter id="Xtek3QKTN0GBXsJpZN0zxg" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.15" />
-                        <Parameter id="hyteutvvmEK_GWHxyiHv5w" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.282" />
-                        <Parameter id="FF_fEzXHok6S5hbgn53wCQ" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.78" />
-                        <Parameter id="z1S4KBk00EutRPIpY3ml_g" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.456" />
-                        <Parameter id="Cm8poWXYHUOsw0a-BbxdwQ" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="2.41" />
-                        <Parameter id="XJEg3z_Gj0S7gVNGpGMrug" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0035" />
-                        <Container id="pJmj_UrpO0ioIgKx0SwyWg" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="ColonSigmoid" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="OVdJLins3kKvW0s2nNAicw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="1osczgwgJEynjimFveRdZA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                            <Container id="ItRC9w0HRE-aMtQkK8Bvzw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Children>
-                                <Parameter id="HY8xDY45jUOoamzNgXoFCg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" visible="0" canBeVaried="0" />
-                                <Parameter id="OcSPFyCPfEuAxf2_L1uCXw" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="LQuH1MHvJ0af2kvb_nXBJQ" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="ColonSigmoid" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="5yJ3TVMcQkm9mdmGn_QT4A" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="pyrKd7S9rEiRInNze_pbZg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                            <Container id="lz4mOoXV8Euef_kefR7E3Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Children>
-                                <Parameter id="CZxl-96H7kWiUN6DEtGLMg" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                                <Parameter id="_lQPBCOtSEasK-jtOO0Bag" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" visible="0" canBeVaried="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="hmTQ2xRfwU-6I_WaFzZk6w" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="ColonSigmoid" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="jU2F_dZJh0-nJfjI_mtEDA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="org4IWo7ykSwKwpFrJfZ0g" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                            <Parameter id="qkZwvivRPEeJHY6dDz9yug" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_pH_INT" visible="1" canBeVaried="1" />
-                            <Container id="T-_4_5MHXUm_W7pdAIaHuQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Children>
-                                <Parameter id="qWeey3NEwUeTBgUXvqzKsA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                                <Parameter id="rAP-wNQ98EG6o4xQ3BTSZg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_colsigm" visible="0" canBeVaried="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="UChU1u3Cik-a1gogAusD9g" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="ColonSigmoid" />
-                            <Tag value="IntestinalSecretionSource" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="xPJKoxIHlEutqqs6YL8_wQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="BRHEn_EdYEa79TtREb-ItA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                            <Parameter id="5fWkLG9w40mnBDpfzjhJAw" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.3" />
-                            <Container id="7uqmBLsc70aTLZZC5dqXrg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Children>
-                                <Parameter id="0wKIIzFbjket5m54rgMFIA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                                <Parameter id="9tobjdlOJUe2dQjuCCQdnA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_colsigm" visible="0" canBeVaried="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="NteNcYyCr0O_9h8y58MLlw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule" />
-                      </Children>
-                    </Container>
-                    <Container id="3iJVLrFIHUq3bKDxKwFnaw" name="Rectum" description="Rectum" icon="Rectum" mode="Logical" containerType="Compartment">
-                      <Children>
-                        <Parameter id="Mawan_h3hUOJTSsBr0sZ-A" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="Individual_PKSim.PARAM_Tissue_Weight" visible="0" canBeVaried="1" displayUnit="kg" />
-                        <Parameter id="vAYESX_mrU2BBEhcyQ-bfw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="MucosaVolume.VOLUME_MucosaRectum" visible="1" canBeVaried="1" displayUnit="l" />
-                        <Parameter id="AJgdiy42jk2Z3Dpp_cGSgA" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Q_lymph_mucosa" visible="1" canBeVaried="1" displayUnit="l/min" />
-                        <Parameter id="Kjq5DWFvzEqa9VyQpEXTXw" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="VascularEndoVolume.VOLUME_VascularEndo_rect" visible="1" canBeVaried="0" displayUnit="l" />
-                        <Parameter id="OKyrt6PciUiCKCqXBrGcjQ" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_J_iso_Mucosa" visible="1" canBeVaried="1" displayUnit="l/min" />
-                        <Parameter id="YUU0FqULTU-vFABRSuzmOQ" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Q_mucosa" visible="1" canBeVaried="1" displayUnit="l/min" />
-                        <Parameter id="tqRf9VmdSkigRKMidDlx6Q" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_f_cell" visible="1" canBeVaried="1" />
-                        <Parameter id="tPrdyG4yM0W336zJqkgC5A" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                        <Parameter id="y6ulukIt-kuzSfqSlUgcGg" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                        <Parameter id="SbinggNT6UeqmjeefGq9vw" name="Fraction of regional blood flow rate" description="Regional blood flow fraction supplying the mucosal tissue of the segment" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.055" />
-                        <Parameter id="robS9WQHUUCRsaSbzPpdcQ" name="Fraction mucosa" description="Mucosal fraction of regional intestinal tissue mass" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.3" />
-                        <Parameter id="Hvbcq6oOp06Jf7LM9Ap9AA" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="4.5E-08" displayUnit="µm" />
-                        <Parameter id="_J97kvIpc0Glz-f6R20qOw" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.05" />
-                        <Parameter id="gdojvG9TpUeT32xM_2GmfQ" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" visible="1" canBeVaried="1" value="1.86944444444444E-10" displayUnit="ml/min/N" />
-                        <Parameter id="PV_cwaT2LE6uMA91Hn6SCg" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="2.5E-07" displayUnit="µm" />
-                        <Parameter id="E5kqnWrm-US6ElrvxqDx9A" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.06" />
-                        <Parameter id="mCekDmzPAUK_ti3pmZjWPg" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0487" />
-                        <Parameter id="Mgljjs1wjE-FdvlDo5agSg" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.08" />
-                        <Parameter id="-0nRU_CgbEGybUGKaCz-Ng" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.08" />
-                        <Parameter id="9v7Cu0r7JEiCcgC8Toem0A" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0163" />
-                        <Parameter id="e9sbkv1IsUaeWTiGT_dxOQ" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.718" />
-                        <Parameter id="undWlVmFG0-luNEP-672lA" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.8" />
-                        <Parameter id="GltQUrxW4UKyIEF-u_wKYg" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.158" />
-                        <Parameter id="P3dDXrt2I0-y-d4ZDEoFQA" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-                        <Parameter id="JJ05vRpSd0iXQWNh-6IgXw" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.141" />
-                        <Parameter id="ixw9tEGn5kaTq9puJZYYIg" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.69" />
-                        <Parameter id="dUzvONjY606hmTSFdGMjLQ" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0483" />
-                        <Parameter id="VpzPJ3fSi0KXGIbQnaOz-w" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0375" />
-                        <Parameter id="X3VdRf6Hrkq41GSh9IdWwg" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0182" />
-                        <Parameter id="dWFV_5sBuUWbenGU99QIqg" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0124" />
-                        <Parameter id="M8bWUkzK9EKcHOjbzJNCHA" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.282" />
-                        <Parameter id="_yYG9_xVGECGwGn1mO42Sw" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.15" />
-                        <Parameter id="BDxOaYTYVUmHyPV_pLTYxg" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.456" />
-                        <Parameter id="kGs8bp3CVkKDhN5hWzlAcw" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.78" />
-                        <Parameter id="QPZh4jqNX0iNIfJix9Lidw" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0035" />
-                        <Parameter id="V6SOpxOsJEmJlfNpqa0MQg" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="2.41" />
-                        <Container id="CXXEeRMxZU-wWTrT4YIzVA" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                            <Tag value="Rectum" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="H-GnQPShi0-yiq5emns1nQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="RFAQTi1h7EyMO7cv6qGCLw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                            <Container id="PC0lYCPKyE2tNK1k3cHdoQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Children>
-                                <Parameter id="WEx4n-rSP0eik3a7m-_nEw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" visible="0" canBeVaried="0" />
-                                <Parameter id="xODjLglqmkyz4bMkrtIIvw" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="A3QoloDj00WaEjb1ONwwKw" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                            <Tag value="Rectum" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="SLprs46gFES0GQpdbHyHOg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="GQ3NO0dJwUetk1cyzvbkmA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                            <Container id="OWLHXJ7SpEyiLyjR8Op0ew" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Children>
-                                <Parameter id="hOFWhJm7HEeejkmzBgO1JQ" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                                <Parameter id="fA2UkF0zVU-RFXeiIruz4Q" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" visible="0" canBeVaried="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="Ske4CMSGVEmut7Tm9FygjQ" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                            <Tag value="Rectum" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="DbC68L27H0KVoziBYS2pPw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="y4kIr-Ir6kaJRBcge5FhrA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                            <Parameter id="x-n8zPv8G0W8X75alUq4yA" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_pH_INT" visible="1" canBeVaried="1" />
-                            <Container id="Dz-jTR2kmESM2QsrDIVbRg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Children>
-                                <Parameter id="3W029FgWUUqQOqtXJHgx9A" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                                <Parameter id="KeuwCb07xkGSALmXuoFz3g" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_rect" visible="0" canBeVaried="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="Wg0MyzCwzU6ebHpo_fikEg" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="IntestinalSecretionSource" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                            <Tag value="Rectum" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="x8jYN3S6F02jasW8Y-KILg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="KogXsBRZ8UmbEniRJ-EgpQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                            <Parameter id="6sKnMesiP0ODqRYn70P-vw" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.3" />
-                            <Container id="Pb6D79dIK0GGxsP4s7siUw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Children>
-                                <Parameter id="OHl1KU9mlkKHtBABy7yhTA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                                <Parameter id="Dqfk8oMNK0iNxL-wpXuQ8A" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_rect" visible="0" canBeVaried="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="d7vCSNmn_0mPmGtNL2ePxA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-              </Children>
-            </Container>
-            <Container id="68uNt9I2akWceVNiduAVNg" name="Liver" description="Liver" icon="Liver" mode="Logical" containerType="Organ">
-              <Tags>
-                <Tag value="TissueOrgan" />
-              </Tags>
-              <Children>
-                <Parameter id="e5IKA77wrkmApHc_RsrVag" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="Individual_PKSim.PARAM_Tissue_Weight" visible="0" canBeVaried="1" displayUnit="kg" />
-                <Parameter id="bm6W4BJkdkqW4slkseuIIQ" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="VascularEndoVolume.VOLUME_VascularEndo_liv" visible="1" canBeVaried="0" displayUnit="l" />
-                <Parameter id="7dhjNHOfiE-PJAIzxQ0GgA" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Lymph_flow_rate_Liver" visible="1" canBeVaried="1" displayUnit="l/min" />
-                <Parameter id="iLltgbVEnkyz7aRj8LiqEw" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate_Liver" visible="1" canBeVaried="1" displayUnit="l/min" />
-                <Parameter id="nHlYOocRFk-B3Flsm21aPA" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_f_cell" visible="1" canBeVaried="1" />
-                <Parameter id="DT5qS_0bX0eC14Jk2XQX6A" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Q_from_Qspec" visible="1" canBeVaried="1" displayUnit="l/min" />
-                <Parameter id="cK-Hgcb0_E22VVgDts1jWg" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                <Parameter id="dV5vBiv7KUa_hpo4vtSNVA" name="EHC continuous fraction" description="Fraction of biliary secreted compound continuously entering the duodenum without being temporarily stored in the gallbladder. The fraction of hepatic bile directly entering the duodenum is species-dependent and amounts to about 30-50% in fasted humans to 100% in rats, because the rat lacks a gallbladder." persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" visible="1" canBeVaried="1" value="0" />
-                <Parameter id="u5NUVZCh-E-UBLJ1iPvejw" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.75" />
-                <Parameter id="qg5-9c7ZVkmi6AmblD1cIg" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                <Parameter id="3k4cECEP3k24E5lTCo1EyA" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" visible="1" canBeVaried="1" value="3.88888888888889E-11" displayUnit="ml/min/N" />
-                <Parameter id="V_UCG7k-z0--k_YZyVs4Xg" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="3.3E-07" displayUnit="µm" />
-                <Parameter id="ohFMRIBQjEaYKqldVnkXFA" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="9E-08" displayUnit="µm" />
-                <Parameter id="qldwiGGqXUa9JiFow_WhlA" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.8" />
-                <Parameter id="VEwdXO5fG0mV9X6mICtvdA" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.069" />
-                <Parameter id="HR0nkuFZFke_H5vSA5POqQ" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0348" />
-                <Parameter id="Rpsq5-qUA0mmsFH9Auh5Mg" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.17" />
-                <Parameter id="cvHY5uHE2EC1xB1qyNioCA" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0252" />
-                <Parameter id="aWUYBDRSNUOAY4oqF83Z1w" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.184" />
-                <Parameter id="H0scByCotkiFdszKgWfRkg" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.086" />
-                <Parameter id="e36ogS32VkaHJ5bgzwh7Ng" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-                <Parameter id="L0ewiPBL50-PZYugLNqB5w" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.161" />
-                <Parameter id="OITyRefJuEmsWMGRs-oTuw" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.751" />
-                <Parameter id="DHPCZHNARkeWMQ6HbA2gSg" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.747" />
-                <Parameter id="3m6lwyxLSkapQQmUQmNj-w" name="Number of cells/g tissue" description="Number of cells per gram tissue" persistable="0" isFixedValue="0" dim="Count per mass" quantityType="Parameter" visible="0" canBeVaried="1" value="139000" displayUnit="x10^6/g" />
-                <Parameter id="Go-vUKPe70G3qKkyA2xCKA" name="Microsomal protein mass/g tissue" description="Microsomal protein content per gram tissue" persistable="0" isFixedValue="0" dim="Mass per tissue" quantityType="Parameter" visible="0" canBeVaried="1" value="0.04" displayUnit="mg/g" />
-                <Parameter id="OACV14cyDEW0FNx3Pp0upA" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.163" />
-                <Parameter id="xC97_i-azk-Exni8Xfqdjg" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0232" />
-                <Parameter id="OOGCc6Up5UuIAcWb5BqOiw" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0135" />
-                <Parameter id="FttnovQ8jE2H85FVaD1xuw" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0472" />
-                <Parameter id="WzMcyLLzXEitGXpYk1rNXQ" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0238" />
-                <Parameter id="qcoyGTe1lUySO7dyTh2XVA" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.21" />
-                <Parameter id="eewg2oHyAE2QTGKEVjiXbA" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.161" />
-                <Parameter id="W4_kZwQbV0-0PuQD84O-2w" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.481" />
-                <Parameter id="JH1B0901QUiJeMGTtMVLYQ" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.68" />
-                <Parameter id="kN1zcew8NUK6FhMdDIJNpg" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="4.56" />
-                <Parameter id="zAizM2Y9rU6nb-fjX-FFzA" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0088" />
-                <DistributedParameter id="W0LFWWwy60G-4g9SlPthlw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="hCK1v9f88UC6qNfHPkoH2w" mode="Logical" visible="1" displayUnit="l">
-                  <Children>
-                    <Parameter id="1n060jTEdEGoZo78_IiYaw" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.513257752570375" displayUnit="l" />
-                    <Parameter id="lXxEIi9s1ke9oOBqPNIjFg" name="Mean" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" value="1.89954571193648" displayUnit="l" />
-                    <Parameter id="EL21ig4xeEuv4fEQaK6-sA" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" value="0.444228460417443" displayUnit="l" />
-                  </Children>
-                </DistributedParameter>
-                <DistributedParameter id="VRYwlvJhq0yjOBI3xFw2MA" name="Specific blood flow rate" description="Blood flow rate normalized to the organ volume" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" formula="vX9VQTDO-EO9683QII3tUw" mode="Logical" visible="1" displayUnit="ml/min/100g organ">
-                  <Children>
-                    <Parameter id="1tYPngFiMkWPljp_XnpUWw" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" displayUnit="ml/min/100g organ" />
-                    <Parameter id="LvnjBuVPmUObsxmd91kb7Q" name="Mean" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" visible="0" canBeVaried="1" value="0.1794" displayUnit="ml/min/100g organ" />
-                    <Parameter id="xeOUMzWAXEilMo2Z2ktcBQ" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" visible="0" canBeVaried="1" value="0.00897" displayUnit="ml/min/100g organ" />
-                  </Children>
-                </DistributedParameter>
-                <Container id="kLQaFdxWjEyQKZou_zICsg" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Liver" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="v4M10qN5wk60MCTBQZhKkw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="HJ1A0jN2d0aPq9fMUWoH1A" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Container id="1xRmTQF-7EafpN1OiOEedg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Children>
-                        <Parameter id="InwDqFPHAkS2KY0VDkkXjQ" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                        <Parameter id="028AHYwu302UWHGzw8k-2w" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" visible="0" canBeVaried="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="yvxjl1guzkC2ZmC3cHheTA" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Liver" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="d1GW6SyeTkmByjHG31z79A" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="8G4Kgdi1K0uNrqqbuYkxbA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Container id="g5rTcQz7zUyLTgvBFDq-LA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Children>
-                        <Parameter id="ktv4-_7TrkC6cyOAcmZ9MA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                        <Parameter id="BzrE_VqCC0eiA6pNiAFe5g" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" visible="0" canBeVaried="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="Ky2hZE0gkU-xY-fmUfJckg" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Liver" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="l9jcbNvX2EuODRqI-AIjBQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="gR3T3iwDUUe_bvzvkpCZjg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Parameter id="kniU_b4POkucVA8VtJ54BQ" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_pH_INT" visible="1" canBeVaried="1" />
-                    <Container id="KiVTCsksX0a3US9zdqu7kg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Children>
-                        <Parameter id="jz9KE9KxkkyIypzxf7gHlg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_liv" visible="0" canBeVaried="0" />
-                        <Parameter id="46ZtxfoYvkWR1WUwM3yXSw" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="WiPCGGPb6EybGjmu7KSb3g" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Liver" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="D5WyqBJemkixfEWwDxUqUQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="PO3HPzHzEkGVQEU4mKdauA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Parameter id="v_AZWvXSxkOR7cSgNGtAPQ" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.23" />
-                    <Container id="hr9unE0AlEGsggfo2qv0vA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Children>
-                        <Parameter id="BKYj2KdsJE6km0hn7bGPpw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_liv" visible="0" canBeVaried="0" />
-                        <Parameter id="qgrkXSPwYEG9PG7Hqwxgkg" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-              </Children>
-            </Container>
-            <Container id="1NHfU3YvTkunbbrtDU6e9g" name="Lung" description="Lung" icon="Lung" mode="Logical" containerType="Organ">
-              <Tags>
-                <Tag value="TissueOrgan" />
-              </Tags>
-              <Children>
-                <Parameter id="aX9s5YA970m3oOnTN5agJg" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="Individual_PKSim.PARAM_Tissue_Weight" visible="0" canBeVaried="1" displayUnit="kg" />
-                <Parameter id="AyTbjPtpc0u3Ops0hoT8kA" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate_Lung" visible="1" canBeVaried="1" displayUnit="l/min" />
-                <Parameter id="buHCE66HAk29M1XAnLAJ7A" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="VascularEndoVolume.VOLUME_VascularEndo_lng" visible="1" canBeVaried="0" displayUnit="l" />
-                <Parameter id="QEtT3mQnJE-VYKDHUiNWmg" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Lymph_flow_rate_Lung" visible="1" canBeVaried="1" displayUnit="l/min" />
-                <Parameter id="UQS009QdnUmpUWXNYbpa_Q" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_f_cell" visible="1" canBeVaried="1" />
-                <Parameter id="sTGBoIRG8kWdItHpmHHqiw" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Q_lng" visible="1" canBeVaried="1" displayUnit="l/min" />
-                <Parameter id="OzWRo-1GT0SQ98yp0Y6VSA" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                <Parameter id="yVM5kmUVPk2p4Mfk8zO_jw" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.75" />
-                <Parameter id="bmB6uGdgt0urJhRLY45Cfg" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                <Parameter id="i6H867pDQ02bjFotKqW99w" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" visible="1" canBeVaried="1" value="5.66666666666667E-12" displayUnit="ml/min/N" />
-                <Parameter id="mmOz3PCQpkqhTRUhgxhgiA" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="2.5E-07" displayUnit="µm" />
-                <Parameter id="TGOrOM7B9EGnJj3_6GKZGg" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.05" />
-                <Parameter id="NE-jFDPSnk6B9C1AW8NPsg" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="4.5E-08" displayUnit="µm" />
-                <Parameter id="LVszf2sVW0mWbwUhhrg8Tg" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.01" />
-                <Parameter id="tysE01abck-zUuO4ljytig" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.003" />
-                <Parameter id="fKsV_H44IU6rW-jZMaIl0g" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.009" />
-                <Parameter id="u59LE9lPm0SSkgVbGlAHdw" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.183" />
-                <Parameter id="7lUDEni8kUqjJ9ALZ-H24g" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.807" />
-                <Parameter id="ASUZ2kUN3EiVBj2ibdlZ7A" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.811" />
-                <Parameter id="ueynVKU6OkyQdSOx8njx0w" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.168" />
-                <Parameter id="CymX8QaER06KzT9aSm4ADw" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-                <Parameter id="Xgqhi5e_TEmX6zty13y_kg" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.212" />
-                <Parameter id="jArOw7cK90GOFQfEHXQ8lw" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.188" />
-                <Parameter id="B3acfAzYlUS10mUgYigrGg" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0204" />
-                <Parameter id="K8cbTBkZpE6PjasoEhTb8A" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0215" />
-                <Parameter id="YcQw4-vkhUmHwjxFHsX27w" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0152" />
-                <Parameter id="YpUnca-LjkO1jnOCl1rZ2A" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0123" />
-                <Parameter id="JOIMn0C900m73Uynu6W7fQ" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.11" />
-                <Parameter id="PrX0NnOQl0KQAxXkJJWs4g" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.336" />
-                <Parameter id="zeUPROeF1kuiJ-JgY2hcig" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.74" />
-                <Parameter id="YtmskqRA9UKtnvtUS6v2AQ" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.238" />
-                <Parameter id="MZcUFjLzvUCdXLY8TZGkBg" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0044" />
-                <Parameter id="1HuE09IgIkGqedlGYKfF8g" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="3.91" />
-                <DistributedParameter id="ykcP_b2IxE6DqNkGJOWAiQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="XdCQKEe790qYe1FD9LB3tg" mode="Logical" visible="1" displayUnit="l">
-                  <Children>
-                    <Parameter id="S_HiNgujdEmXAK9OAB-wLw" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.403743139486877" displayUnit="l" />
-                    <Parameter id="yp5nKFHZKU6HzdgEg62V8g" name="Mean" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" value="1.04276351262352" displayUnit="l" />
-                    <Parameter id="EVn-ilA4KEmxo2JkcdC_Ag" name="GeometricDeviation" description="Geometric standard deviation of LogNormal distribution" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1.3" />
-                  </Children>
-                </DistributedParameter>
-                <DistributedParameter id="TJUSUyp7eEi167KEHwGUzQ" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="JOWaysd5Nku55XFm4n3plw" mode="Logical" visible="1">
-                  <Children>
-                    <Parameter id="DNUJeFcy_0iN_tLIBsFvTg" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                    <Parameter id="Zh6AE8rGX0K9KFxlAc3WoQ" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.58" />
-                  </Children>
-                </DistributedParameter>
-                <Container id="S9nTwpXAk0mjoLYsPZDHhA" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Lung" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="5fEV7rSSK0ufAkCQyUGl-A" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="YeJOBqBgM0yEJ9QWbUIppg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Container id="EoWWSBqczEiG2vz2yYLGbQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Children>
-                        <Parameter id="4nQGryaljk2-ikAnaZs08Q" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                        <Parameter id="MbmhnGGLykGap0jwzPPpdw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" visible="0" canBeVaried="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="sntQYIleCUO8SGMqvmOx9A" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Lung" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="rdSk3FGrQ0WLkvmXLXiYnw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="8z9QjTXkfUG4Sl4nbpaO2Q" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Container id="yHMQaKPKp02DihOtzxh18A" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Children>
-                        <Parameter id="7Vq7cnlubEmWh02Ozu3svQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" visible="0" canBeVaried="0" />
-                        <Parameter id="cV296wjENkqDd3RHcCyYlw" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="l67dYbDruk65Ld_SSqhXGg" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Lung" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="nnxupR60REGUetu3mfps7A" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="6f_nYryGWUGffz_ISMa0cA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Parameter id="oo0yclk34kiesirda3ysrQ" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_pH_INT" visible="1" canBeVaried="1" />
-                    <Container id="CcSwUHEzQkeLMIa7oo83yQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Children>
-                        <Parameter id="z1kxDo2KrEyIpwspHzXAOg" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                        <Parameter id="F6WMQBJijkaJy-JMNOuw2w" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_lng" visible="0" canBeVaried="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="ay3McSvbZkqRugX8fq_pag" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Lung" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="JJPso-fZykWWPCdWCTwTFQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="fGEzUnGFS0azJnZ-w7eVLw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Parameter id="bFbzLIJAhEe9M4QM-DCrog" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="6.6" />
-                    <Container id="i19a2BgUIk6VN-8bUS6CQg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Children>
-                        <Parameter id="kdBjNudXH0aehZQsF_hfBA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                        <Parameter id="z2oRzZyAk0mB7KLeXtUV6w" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_lng" visible="0" canBeVaried="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-              </Children>
-            </Container>
-            <Container id="cFodjlKXqk-iSGVKNrmpUQ" name="Muscle" description="Muscle" icon="Muscle" mode="Logical" containerType="Organ">
-              <Tags>
-                <Tag value="TissueOrgan" />
-              </Tags>
-              <Children>
-                <Parameter id="Y05FBtbKDkuSRVuc0FkDcQ" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="Individual_PKSim.PARAM_Tissue_Weight" visible="0" canBeVaried="1" displayUnit="kg" />
-                <Parameter id="o2t6w3386UGUw6xoajFeXA" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Lymph_flow_rate_Muscle" visible="1" canBeVaried="1" displayUnit="l/min" />
-                <Parameter id="BxobAF2y30qJ9Dq95MdnSQ" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate_Muscle" visible="1" canBeVaried="1" displayUnit="l/min" />
-                <Parameter id="jl6hb3J-RU2S8f0EsSk26w" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="VascularEndoVolume.VOLUME_VascularEndo_mus" visible="1" canBeVaried="0" displayUnit="l" />
-                <Parameter id="nvji4D1_AUa6wJih_RK6ug" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_f_cell" visible="1" canBeVaried="1" />
-                <Parameter id="Kiij3BrO30WoYgzrh40Zeg" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Q_from_Qspec" visible="1" canBeVaried="1" displayUnit="l/min" />
-                <Parameter id="WZsWSo70SE2HenomjY85Ug" name="Peripheral blood flow fraction" description="Blood flow fraction in organ used for calculation of peripheral venous blood concentrations" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" visible="1" canBeVaried="1" value="0.287" />
-                <Parameter id="8-cMXrZkYEm_PW2qThxnuA" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                <Parameter id="DLyJP1DnA0i-vq0EoYLj-w" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="2" />
-                <Parameter id="WUYAcwtQC0CUhy65PACBWg" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                <Parameter id="nKWZjgKRm0OjaZg5UNbjzg" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" visible="1" canBeVaried="1" value="4.16666666666667E-12" displayUnit="ml/min/N" />
-                <Parameter id="7Rpw9O_QS0K0JsmwkB52eA" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="2.5E-07" displayUnit="µm" />
-                <Parameter id="u0LxEGjp6kSHTNEO7jFMyA" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.05" />
-                <Parameter id="JN1fojy7pEWAXMcIgaN-uA" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="4.5E-08" displayUnit="µm" />
-                <Parameter id="Hzf74wgT7kazi1CnvYz66g" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.025" />
-                <Parameter id="BEuUYGZcpEyV_lCr54kV4g" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.064" />
-                <Parameter id="90ElpU2x_0ihpL2K5SHbmA" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.059" />
-                <Parameter id="HsK6vlmRCEeFWhUO5X_jmA" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-                <Parameter id="ophAL1lbqkaq62cX7tfEzg" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="2.42" />
-                <Parameter id="DxY8CCjSLU6zYglhJyCr1w" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0009" />
-                <DistributedParameter id="8ro8SKLVWEmzeWZt838G1w" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="Y8rX_o0cQ0mQgbjPuULn2A" mode="Logical" visible="1" displayUnit="l">
-                  <Children>
-                    <Parameter id="YwZkVif0HESB-TwKT3YP9A" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.534700213215445" displayUnit="l" />
-                    <Parameter id="PWQrRGYOdUu4q_CaZOdDhg" name="Mean" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" value="26.0528937105536" displayUnit="l" />
-                    <Parameter id="8MmdPUZOsEKZZfhdf8Ad6g" name="GeometricDeviation" description="Geometric standard deviation of LogNormal distribution" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1.1" />
-                  </Children>
-                </DistributedParameter>
-                <DistributedParameter id="5IIRBf7U1kCc4L1kYww6qQ" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="yornantdUUyUTe6Y8Grpxw" mode="Logical" visible="1">
-                  <Children>
-                    <Parameter id="Mpg8hAL3hUu01Vjb7dxpGQ" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                    <Parameter id="M0GSAi9BBkyPj11eiHizow" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.013" />
-                  </Children>
-                </DistributedParameter>
-                <DistributedParameter id="YXZlsuEcykaxmCJRz0roTQ" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="lmKg6vBoRUegkDvYobY0Eg" mode="Logical" visible="1">
-                  <Children>
-                    <Parameter id="diSbQ-SzJEmj9D4ZmmHEow" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                    <Parameter id="c4PVQrWiRU-DiP-SdNSvxQ" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0238" />
-                  </Children>
-                </DistributedParameter>
-                <DistributedParameter id="fhrEiHJCeUKpN9j4E3A3CA" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Yn9O8BGW6EWWviNExqK-yw" mode="Logical" visible="1">
-                  <Children>
-                    <Parameter id="JGQPx8CBDk6ol2ZfDOrkoA" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                    <Parameter id="xRVEcCOtmkS5Ri2Lusgqag" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0072" />
-                  </Children>
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-                <DistributedParameter id="tYM4guw0-kKbmcHF1F1UDw" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="-XBc4pAx90-eyQuAdUHQKQ" mode="Logical" visible="1">
-                  <Children>
-                    <Parameter id="zmkQy7y_AUqevRn5AL0kAw" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                    <Parameter id="kqdeVQOlSUq7EkEghQXj2Q" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.177" />
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-                <DistributedParameter id="M9XdCpP3V0GPGycmJp0ptQ" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Wj6t-DKA2U6JPNxtyqBqxQ" mode="Logical" visible="1">
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-                    <Parameter id="F6l6CpqtjkCGcMj1FPiOzw" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                    <Parameter id="Jur8_3hgM02Xi_ONICLi3A" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.16" />
-                  </Children>
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-                <DistributedParameter id="e0QdgX97NEeeitOHI0dV-g" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="jsqEDNOk7kiZFMj260kWFg" mode="Logical" visible="1">
-                  <Children>
-                    <Parameter id="33Wvhr_SL0KNKRl0kfIgPg" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                    <Parameter id="ug5S5eZiekKh95rqTJGoxA" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.76" />
-                  </Children>
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-                <DistributedParameter id="-4qV3D5jnkaZPXv-LHqn8g" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="zCdO-H86akq8orIEg7iBNg" mode="Logical" visible="1">
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-                    <Parameter id="YLFs0QBjDkKOTbC1aExb0g" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                    <Parameter id="FyryxmMH7kaCW3sZDqDp0w" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.811" />
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-                <DistributedParameter id="xhYb7S8JYE2EWEzBrpIDsQ" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="4izQ8bd6vEiACKkcqSUb0Q" mode="Logical" visible="1">
-                  <Children>
-                    <Parameter id="JwNh4jCnS0-pAFDgJXl4Og" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                    <Parameter id="sE9_asFgFEiQlRoQN3Ad1g" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.022" />
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-                <DistributedParameter id="FUEtulBTGUiqopiNC3cKPw" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="apaQnWC1R0mkdjhDCTCN-A" mode="Logical" visible="1">
-                  <Children>
-                    <Parameter id="hikrOmCKbUqRFSx4zQm_JA" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
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-                  </Children>
-                </DistributedParameter>
-                <DistributedParameter id="8RyvpRZT90enG2G8QLWq6g" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="aroJrJCidUC41UJZ0qqpSg" mode="Logical" visible="1">
-                  <Children>
-                    <Parameter id="vrz6bi1kyU20i39_9AtnjA" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                    <Parameter id="mo2r76hLUU-m-ZHUx9OwUQ" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0078" />
-                  </Children>
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-                <DistributedParameter id="vibxWP3ZUE-HAjcBCvCzzQ" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="EZ16uJUmxky-L0cyidKiEg" mode="Logical" visible="1">
-                  <Children>
-                    <Parameter id="ndkMC6Alak2efMez83zpeQ" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                    <Parameter id="65VttTmjNEiscGtwN5WzHg" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0042" />
-                  </Children>
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-                <DistributedParameter id="3q11PFWvME62pdlMXoLCFw" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Cd3xvocf6UykHAfN8w9DIw" mode="Logical" visible="1">
-                  <Children>
-                    <Parameter id="qv1_183VLUG2ql8QTVtr2Q" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                    <Parameter id="0mlnQ77Oik-bLrDXgBcfNA" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.079" />
-                  </Children>
-                </DistributedParameter>
-                <DistributedParameter id="v3estWiiQEq9Y7RwTxPrKQ" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="gvj2SHge5UmWjBbSrA_jLg" mode="Logical" visible="1">
-                  <Children>
-                    <Parameter id="JKuLJId2w061iKe4lZSmRA" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                    <Parameter id="MZFJFITppEKFQALPQlTRPQ" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.19" />
-                  </Children>
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-                <DistributedParameter id="xtCx2Z3qOkem5HFzlKVsAQ" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Yl_tpy9xa0q8-WXbAPkjRw" mode="Logical" visible="1">
-                  <Children>
-                    <Parameter id="Oe5HAGzJB0-IkXLz5Dt5SA" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                    <Parameter id="26k3zoTUqkmH0BOf4Kbb2w" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.666" />
-                  </Children>
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-                <DistributedParameter id="1Njc9MrgGUOEmWBopUyJMg" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="3axkvavtF0-lwm_8sylxvw" mode="Logical" visible="1">
-                  <Children>
-                    <Parameter id="r3arlO2S-Ey1HxN330OUMQ" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                    <Parameter id="dPacOSkNMk2BhVru5skVGw" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.76" />
-                  </Children>
-                </DistributedParameter>
-                <DistributedParameter id="dwQ2cKbIN069oSdNxIqj2w" name="Specific blood flow rate" description="Blood flow rate normalized to the organ volume" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" formula="iglelZ00bUCAd9xdA0cIZw" mode="Logical" visible="1" displayUnit="ml/min/100g organ">
-                  <Children>
-                    <Parameter id="m4vus5BW3UW9BuNq8ZCc1A" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" displayUnit="ml/min/100g organ" />
-                    <Parameter id="UvvuwT_1W0-XfCYdgSCB_A" name="Mean" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" visible="0" canBeVaried="1" value="0.03419" displayUnit="ml/min/100g organ" />
-                    <Parameter id="0PtdYq8PlUWjrJC3o2Sd_Q" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0017095" displayUnit="ml/min/100g organ" />
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-                <Container id="yw1lF6NGzUebqB1RzY5lcA" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Muscle" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="ju6qZD0cN0C8nFq-to_6oA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="y67-Dfjvpkef231Bdn_pkQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Container id="v6uo2e2jcUCHg6I954vdXA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Children>
-                        <Parameter id="AKSaO63eS0mmvWgcOjV-KA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                        <Parameter id="91VaTS1kIUyf8pPuXhQ03Q" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" visible="0" canBeVaried="0" />
-                      </Children>
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-                </Container>
-                <Container id="zqX6cO98Rk-cr016qGkvtQ" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Muscle" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="TUyTG4pMnkmUk-u0j3Gb_Q" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="b5Gio-YmWk2YZSXFscfFhw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Container id="0MvW-0rVmk-6HekRbK42Mg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Children>
-                        <Parameter id="3VDf2Bk7Y0OQFEAYlt7VHw" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                        <Parameter id="kbjPd6lHqkmNZoHN2JVY0g" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" visible="0" canBeVaried="0" />
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-                </Container>
-                <Container id="dCF3JWTh6USnRi-gPC27TQ" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Muscle" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="dwMO5J9JTEGphFB5WJhG7w" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="zhfQqMU3PUiCxRhUHFC34w" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Parameter id="1mHxIcZZ80-7q4IGkRSh7Q" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_pH_INT" visible="1" canBeVaried="1" />
-                    <Container id="00r8WWT7k0ymJ-eLafqSjg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Children>
-                        <Parameter id="xviVyZz4t0Sqj2jLnUeJcA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                        <Parameter id="btIhqZZmqE21dAb_cPKtmQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_mus" visible="0" canBeVaried="0" />
-                      </Children>
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-                </Container>
-                <Container id="YvELcqn1Aky_A9v0A1I89A" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Muscle" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="arljOdn-PEWzkaaQ7cgEJg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="kOXMirx7TUyb2GIv_6pvEQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Parameter id="plDZYt9j8kyrS5brFt4RvQ" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="6.81" />
-                    <Container id="VcJ3BhTSAU2QXrhZhX6jqg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Children>
-                        <Parameter id="devsGlaCzkCmYKJ5NIoOfA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_mus" visible="0" canBeVaried="0" />
-                        <Parameter id="SgpojLL650yPIwcrVF2cow" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-              </Children>
-            </Container>
-            <Container id="yixpA99D7kGPx5hmMeQ9zQ" name="Pancreas" description="Pancreas" icon="Pancreas" mode="Logical" containerType="Organ">
-              <Tags>
-                <Tag value="Portal Vein Supplying Organ" />
-                <Tag value="TissueOrgan" />
-              </Tags>
-              <Children>
-                <Parameter id="WzWA-toRXUe5IdDdv7sHpQ" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="Individual_PKSim.PARAM_Tissue_Weight" visible="0" canBeVaried="1" displayUnit="kg" />
-                <Parameter id="YtPoeiIZz0q6NZR14D1jJw" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="VascularEndoVolume.VOLUME_VascularEndo_pan" visible="1" canBeVaried="0" displayUnit="l" />
-                <Parameter id="dMj6dRFYSU2tASq_ghgndw" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Lymph_flow_rate_Pancreas" visible="1" canBeVaried="1" displayUnit="l/min" />
-                <Parameter id="aW8gJJ-MZk-mmb3z-B2p8Q" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate_Pancreas" visible="1" canBeVaried="1" displayUnit="l/min" />
-                <Parameter id="ODOa2pW4skekOe87VlaDow" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_f_cell" visible="1" canBeVaried="1" />
-                <Parameter id="FfXFyACrqkyVcdnJNdgKaA" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Q_from_Qspec" visible="1" canBeVaried="1" displayUnit="l/min" />
-                <Parameter id="OiymGkkcdEC9OXvCXSPbaw" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                <Parameter id="r_mAeBIQfU-NGeXKAM3X-w" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.75" />
-                <Parameter id="ArdqZNThwEGBl-cDKloLTw" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                <Parameter id="mW4ErI-JP0yTcl-l3sf-hA" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.05" />
-                <Parameter id="7Bot_dXDrE219Me7pOMTyg" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" visible="1" canBeVaried="1" value="3.22222222222222E-11" displayUnit="ml/min/N" />
-                <Parameter id="9hu9kBJl2kyJ_ff5YrzIXw" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="2.5E-07" displayUnit="µm" />
-                <Parameter id="48gHM0CEcEWmngh_FHc3LQ" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="4.5E-08" displayUnit="µm" />
-                <Parameter id="UHOd4a5N30GR-4apTuD1qA" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.08" />
-                <Parameter id="CkhZSNJgMUKqTPECZoOsCw" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0403" />
-                <Parameter id="1xhleW78AUmi9p_J9Cjb6g" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.2" />
-                <Parameter id="KEOJvWDWS0WMuyEeYk1_1g" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.01067" />
-                <Parameter id="SJiCMVE7n02JBBDa_lylng" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.13" />
-                <Parameter id="MkLwQtMLd0egy1aV3LchdA" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.06" />
-                <Parameter id="MrjCfZUUNkSuEt3MvheoPA" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.71" />
-                <Parameter id="hViAkQy-FUmJ20_MvSqW1w" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.06" />
-                <Parameter id="VNRUp2G0L0uvVXr3Cr6leA" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.71" />
-                <Parameter id="nDELMvmBj0yEMZcb48Bp1g" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-                <Parameter id="ueVK7waqf0CVK2w2oIQscA" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.12" />
-                <Parameter id="yfIlaLQBxEy01f-PTFuE3Q" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0403" />
-                <Parameter id="2MgcIeMU2EeqWffmSEvUtA" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0403" />
-                <Parameter id="9-7Dj_M8c0-P22Oe870xoA" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.009" />
-                <Parameter id="NFP-GvYFZUqcC1BtP7sx1Q" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.009" />
-                <Parameter id="qFYpHEUsjkiHF_B69_E24g" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.13" />
-                <Parameter id="jH6ByArT0E6Yhtx4ukfgdA" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.12" />
-                <Parameter id="_zhz4YlO_EqRgSKl3JezPA" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.71" />
-                <Parameter id="uQ5SdDR52EqngibXoVTW0g" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.521" />
-                <Parameter id="9dHTFkNww020NSDqCU04Yg" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.00167" />
-                <Parameter id="89YaqZWv5UGCfs0aI-A1_A" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="1.67" />
-                <DistributedParameter id="uehFgNzfR0OjHe6TuuWlhw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="6Qpmxy3Cv0iC9SuRwH2Xmg" mode="Logical" visible="1" displayUnit="l">
-                  <Children>
-                    <Parameter id="VhbnxfOp10-GuiusA31OzQ" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.500987716776352" displayUnit="l" />
-                    <Parameter id="9LRePlixlkKr9XP_Ea9cYQ" name="Mean" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" value="0.153282906300256" displayUnit="l" />
-                    <Parameter id="FENqiyCx4UWLDulEUePaXA" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0412103529546573" displayUnit="l" />
-                  </Children>
-                </DistributedParameter>
-                <DistributedParameter id="mu5MsfhhxUqaQiBQBHvkQg" name="Specific blood flow rate" description="Blood flow rate normalized to the organ volume" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" formula="dJzmMnfaekiojqSMPy2oDg" mode="Logical" visible="1" displayUnit="ml/min/100g organ">
-                  <Children>
-                    <Parameter id="ErevUQMwtkiBcp2qo40uqg" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" displayUnit="ml/min/100g organ" />
-                    <Parameter id="M-X62Et0dkyFJAAlV3QApw" name="Mean" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" visible="0" canBeVaried="1" value="0.3419" displayUnit="ml/min/100g organ" />
-                    <Parameter id="aJAMlisQf02Q6JpexAMUcA" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" visible="0" canBeVaried="1" value="0.017095" displayUnit="ml/min/100g organ" />
-                  </Children>
-                </DistributedParameter>
-                <Container id="XpMoC77tqU2dbzFapP7yNA" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Pancreas" />
-                    <Tag value="Portal Vein Supplying Organ" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="ofzTfPuL4k6XypjRtQNKNQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="n4nwCOrDVEegniT7tswlUg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Container id="kMdUXWgkzU-eIrUzuOcccQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Children>
-                        <Parameter id="nd012faIL0mj0wcqmkLFig" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" visible="0" canBeVaried="0" />
-                        <Parameter id="913hUHuxekOogQ0h1qAE8A" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="cE6Ep5Tc7ESxE43Touo5cw" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Pancreas" />
-                    <Tag value="Portal Vein Supplying Organ" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="uowkoKSjck-brwgw_A7QVA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="DN_t1wOujEmcjVa2FoAZ_A" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Container id="usKna3BG9EObqvXqZv25lA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Children>
-                        <Parameter id="z1dJWV2jZEu9wKRwPwVxrA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                        <Parameter id="6C_sWC-7qUSNky03l2Qqjg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" visible="0" canBeVaried="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="pqwFSmbk-EayJEjapSwGkg" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Pancreas" />
-                    <Tag value="Portal Vein Supplying Organ" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="BCUYVP8HWkWuC1kwrjNTOw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="p7HtWKHJEUeGFPnSfsYnKA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Parameter id="LK7dao0_QUm_Ub-MsdV4RA" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_pH_INT" visible="1" canBeVaried="1" />
-                    <Container id="IkX2ROPDwUKMw9Pdj9RtUQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Children>
-                        <Parameter id="f_HhoZtI5kOS8ONAmu3YnA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_pan" visible="0" canBeVaried="0" />
-                        <Parameter id="m4rMVflkz0CO54yKGb5Nbw" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="tC2LTXmkVkuQv6mD-Lzfig" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Pancreas" />
-                    <Tag value="Portal Vein Supplying Organ" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="Ff7ZmJG68kKlqiyj1cheTg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="IzxCCGlcUUO0DyJqLl6Aqg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Parameter id="Tz0OvwPDNk6moRJlqC_zQw" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.4" />
-                    <Container id="1U3PnXNvkEOtdV-hzFYdxw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Children>
-                        <Parameter id="YmnY3z9kY02Iu6te65tqzA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_pan" visible="0" canBeVaried="0" />
-                        <Parameter id="q2Bw0eXT1EaIW-e26D13rQ" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-              </Children>
-            </Container>
-            <Container id="Gu0B5D5pIUCvs6IxMkDzKw" name="PortalVein" description="PortalVein" icon="PortalVein" mode="Logical" containerType="Organ">
-              <Tags>
-                <Tag value="BloodOrgan" />
-              </Tags>
-              <Children>
-                <Parameter id="osIW6gXHhUCdaHSe2CJVRw" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="Individual_PKSim.PARAM_Tissue_Weight" visible="0" canBeVaried="1" displayUnit="kg" />
-                <Parameter id="nyyNtBo_jUiDXAOU8_irdQ" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Q_Lymph_pve" visible="1" canBeVaried="1" displayUnit="l/min" />
-                <Parameter id="sRyPz4e2p0Of16GgSuTYCA" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Q_pve" visible="1" canBeVaried="1" displayUnit="l/min" />
-                <Parameter id="6oGkuc1kRUSIJ-XLXNX0Cg" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                <Parameter id="QVdU3DyxU0WJ5HZjPGWUkg" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="0" value="0.75" />
-                <Parameter id="BugDsTCc7k-KrkdY8hqCiA" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="1" />
-                <DistributedParameter id="OXEgwWcmRkmwBNJGoFf13g" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="GiwjOS90A0u31I0_VFzNkQ" mode="Logical" visible="1" displayUnit="l">
-                  <Children>
-                    <Parameter id="8fFCfrAgC0GdbwiQ_WLAkw" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.501110815503086" displayUnit="l" />
-                    <Parameter id="HIWAWCgqs0uCxSwm1EHJzA" name="Mean" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" value="0.83561581977504" displayUnit="l" />
-                    <Parameter id="MrPZ3TBNuUCSRAHSvRX1Nw" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" value="0.041780790988752" displayUnit="l" />
-                  </Children>
-                </DistributedParameter>
-                <Container id="-btXNr8mOEG_8ZCjsspLow" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="BloodOrgan" />
-                    <Tag value="PortalVein" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="O46_JToVp0SMZbC4zAKbig" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="Z2mu5qb0aEaYkG3vGWWyXw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_pls_BloodOrgan_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Container id="mhl3ymwtKk651ifBq4txqw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Children>
-                        <Parameter id="45OeKhiafU2xB_VQWkpDyA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" visible="0" canBeVaried="0" />
-                        <Parameter id="A6V3BjOw5E6zu06qK5wiNw" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="ghMacG-81kSUPN5wkgPsnA" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="BloodOrgan" />
-                    <Tag value="PortalVein" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="WwQnzwCbUU2oNWlj2cSi2w" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="7FO6VfZ-xUWXC9W50WxEcg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_bc_blood_organ_4comp" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Container id="sAR0KioR90W2-sGW4IIdaw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Children>
-                        <Parameter id="VTP2GPlFWkKurbgJFF2VCQ" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                        <Parameter id="IBvpT38dO02DbU10SwM-wQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" visible="0" canBeVaried="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-              </Children>
-            </Container>
-            <Container id="WfLr97AqvkWZzgZ2_DssKg" name="Skin" description="Skin" icon="Skin" mode="Logical" containerType="Organ">
-              <Tags>
-                <Tag value="TissueOrgan" />
-              </Tags>
-              <Children>
-                <Parameter id="woZrTcUjAE28VS3cBLq5SQ" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="Individual_PKSim.PARAM_Tissue_Weight" visible="0" canBeVaried="1" displayUnit="kg" />
-                <Parameter id="Sr1jh1KHq0qT9QsImdBm5g" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="VascularEndoVolume.VOLUME_VascularEndo_skn" visible="1" canBeVaried="0" displayUnit="l" />
-                <Parameter id="l1DQX67QEEa9od4BMgcpgg" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate_Skin" visible="1" canBeVaried="1" displayUnit="l/min" />
-                <Parameter id="2CegWxyB_0K5jDp9c1pZlA" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Lymph_flow_rate_Skin" visible="1" canBeVaried="1" displayUnit="l/min" />
-                <Parameter id="c9I0zbR5NUyUmAOTjRPYOQ" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_f_cell" visible="1" canBeVaried="1" />
-                <Parameter id="YXy4J2x23kaRARhu_1BbdQ" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Q_from_Qspec" visible="1" canBeVaried="1" displayUnit="l/min" />
-                <Parameter id="URZQyWY7OUSieU5e2LjyKw" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                <Parameter id="Pq5JKCBu5EC80O85lxIhuw" name="Peripheral blood flow fraction" description="Blood flow fraction in organ used for calculation of peripheral venous blood concentrations" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" visible="1" canBeVaried="1" value="0.713" />
-                <Parameter id="DlFVvkZAu0-3h0mu64udVg" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1.6" />
-                <Parameter id="-v3Wc3mpDk-3h7lZ6kB7KA" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                <Parameter id="-TNAq6hhUU6c0cHpkAqUpg" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.05" />
-                <Parameter id="PjizWmYeSUCtiJHVYUzagQ" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" visible="1" canBeVaried="1" value="1.66666666666667E-12" displayUnit="ml/min/N" />
-                <Parameter id="6BQQsFuOj0StfkDt1pTbEg" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="2.5E-07" displayUnit="µm" />
-                <Parameter id="Q-Xnrtw-5ESWis7RxOELEQ" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="4.5E-08" displayUnit="µm" />
-                <Parameter id="wFmNdTXsPUe0ErD-jeRXTA" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0284" />
-                <Parameter id="SYQyMA4ufEWQTq8vVXaOFQ" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.1" />
-                <Parameter id="Hkb7Ult-FkSbz_f3-oS3KA" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.046" />
-                <Parameter id="kZbexoOTCUmOCCHAzx2ZYg" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0111" />
-                <Parameter id="LcAtYE1nnUqqW2lTxAF3lA" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.288" />
-                <Parameter id="fOPzQLWiCUW6DLqgWwIXAQ" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.718" />
-                <Parameter id="MtDoiT2TDkK2t3Jeu1gvCg" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.612" />
-                <Parameter id="DGHvMzSM_U20iGSK-0ZUKA" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.096" />
-                <Parameter id="Btya-rGOV0ehCSp4ZDNHoA" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.277" />
-                <Parameter id="mQaDlA8UVkC0QxAuzBmUrQ" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-                <Parameter id="HA4w5kp15kKYjgPAyP6-Vg" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.302" />
-                <Parameter id="GpdEqxq7g0Cxeqkk_1IRaw" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0603" />
-                <Parameter id="kLuypKPeWk2Pyg5yMyc_xQ" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.126" />
-                <Parameter id="FOmw6-jMAUi9Q2hAgSocbw" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0044" />
-                <Parameter id="7fYiX2rHpkCelPp97PW3fw" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0112" />
-                <Parameter id="MEuw_4EjBEaOi70lKYzcSw" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.41" />
-                <Parameter id="BsE6lLwXckCw3Tomt8pcgg" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.382" />
-                <Parameter id="tXgN1hBwaEGEJxS6KHDYpw" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.276" />
-                <Parameter id="-MKNoU26fEmJuLDfJzN6tg" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.47" />
-                <Parameter id="dvX7A9LyQEqXYAmHamTbvQ" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0028" />
-                <Parameter id="3ObnLkCxuEK1gXCscheAbA" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="1.32" />
-                <DistributedParameter id="Ixz2NtZp0EW24vzsDfvt3Q" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="poMArFaJ506hpaTU85lfrw" mode="Logical" visible="1" displayUnit="l">
-                  <Children>
-                    <Parameter id="4Nu46YNvm0yNYkhG11OzIA" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.504248347732562" displayUnit="l" />
-                    <Parameter id="bUAMff3jcUWX1f9hgp0sUw" name="Mean" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" value="3.0298942433376" displayUnit="l" />
-                    <Parameter id="dE0mbkD240KOXpm1hBp5SA" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" value="0.15149471216688" displayUnit="l" />
-                  </Children>
-                </DistributedParameter>
-                <DistributedParameter id="JCfiJJsmakCMOagQ_eOoLQ" name="Specific blood flow rate" description="Blood flow rate normalized to the organ volume" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" formula="QFn_snxVvUiKxy7CrfEx7g" mode="Logical" visible="1" displayUnit="ml/min/100g organ">
-                  <Children>
-                    <Parameter id="qbeKDapx3UCY9FEZnKDYVQ" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" displayUnit="ml/min/100g organ" />
-                    <Parameter id="s011RqEvoUGouWOUQjUE_Q" name="Mean" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" visible="0" canBeVaried="1" value="0.08645" displayUnit="ml/min/100g organ" />
-                    <Parameter id="Uvv2ailmJ0SwfuWZZxfdSw" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0043225" displayUnit="ml/min/100g organ" />
-                  </Children>
-                </DistributedParameter>
-                <Container id="WSZy9a4tjEazdIfolnG7tQ" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Skin" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="8v7lGeMPaE6RUwWSBUL5kw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="0fMMkXpA3UWa4lTiNlVFhw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Container id="3uqwYPltekaGZdel4YkaDg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Children>
-                        <Parameter id="5d3dpoimTkKWI2H8Vnchjg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" visible="0" canBeVaried="0" />
-                        <Parameter id="LBd1mmdCp0yYVchgWpKIaw" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="pPMIx8esx02hUpNFp0-EDQ" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Skin" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="MBl7NhV88EuNjqGBaAC78A" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="BJ5HX_SLFE2Tjvj-SnWeuQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Container id="nsf-7VPYZU-TQn12eL03ow" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Children>
-                        <Parameter id="dc8XoCFhl0ulsYgk1geFEg" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                        <Parameter id="qmkriSPmZEOsxmqmxjkybw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" visible="0" canBeVaried="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="D2BE9ngGEUuvjzRqxqz8rQ" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Skin" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="g2qK1X--xU6IOBRpBYhJmw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="bJF8g460QUOgevpp5W3-WA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Parameter id="QpTPXPZ5bk-PhsaSMies8A" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_pH_INT" visible="1" canBeVaried="1" />
-                    <Container id="HLMuXSJX70GKJIoks8I0nQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Children>
-                        <Parameter id="axJ3uaP36Ey2g_gL885MMg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_skn" visible="0" canBeVaried="0" />
-                        <Parameter id="aYUWStFwykCK2fHF7bXYyA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="3we3dTuwDUm_9NjEJ_wiuA" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Skin" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="lcXh5LyB7028GrHyZ8JNYQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="4WVUuvMrm0KY1fnDnAZNmA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Parameter id="9s3WqR8q-ke6G0s7JS968A" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7" />
-                    <Container id="41R9GUoRKk2WIharI2uVzg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Children>
-                        <Parameter id="ueMBw3u2C0STlpJ_SmsQiA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_skn" visible="0" canBeVaried="0" />
-                        <Parameter id="VyBihUE9LUOj2CSW9w7FTA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-              </Children>
-            </Container>
-            <Container id="Z74M9J1yLEePHDuzV0hz5A" name="Spleen" description="Spleen" icon="Spleen" mode="Logical" containerType="Organ">
-              <Tags>
-                <Tag value="Portal Vein Supplying Organ" />
-                <Tag value="TissueOrgan" />
-              </Tags>
-              <Children>
-                <Parameter id="ewqn6yCR30OBc6yU3l6qRQ" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="Individual_PKSim.PARAM_Tissue_Weight" visible="0" canBeVaried="1" displayUnit="kg" />
-                <Parameter id="pg2SVLXvI0ejrmv_1XF_ZQ" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Lymph_flow_rate_Spleen" visible="1" canBeVaried="1" displayUnit="l/min" />
-                <Parameter id="jvBj9ZZO5k-458bRWTyYCA" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="VascularEndoVolume.VOLUME_VascularEndo_spl" visible="1" canBeVaried="0" displayUnit="l" />
-                <Parameter id="zukgAkf5m0WVXVax9l-Rhw" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate_Spleen" visible="1" canBeVaried="1" displayUnit="l/min" />
-                <Parameter id="OnXxSf8OBUalvAU1P8SW5A" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_f_cell" visible="1" canBeVaried="1" />
-                <Parameter id="HA8toaUBpECQ1LYXPvaJ8g" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Individual_PKSim.PARAM_Q_from_Qspec" visible="1" canBeVaried="1" displayUnit="l/min" />
-                <Parameter id="2TV6HvolsUipPkn7wmEdaw" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                <Parameter id="-1u-VZ1ddUOGkKDwGdjqkg" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.75" />
-                <Parameter id="HA-XhgOi9US-2CCSkB9jaw" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                <Parameter id="-cF9ggpgNE6A083Vu7wK8Q" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="9E-08" displayUnit="µm" />
-                <Parameter id="-QjNc-zxTkyDuuAXE7bbqw" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.8" />
-                <Parameter id="r1GwVm7-lE2okx1foFlNyw" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="3.3E-07" displayUnit="µm" />
-                <Parameter id="ckQ1gMtJgUCFI7z7crDr-g" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" visible="1" canBeVaried="1" value="3.88888888888889E-11" displayUnit="ml/min/N" />
-                <Parameter id="tFWb-Z5u6UuF_s_j1-uCqw" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.016" />
-                <Parameter id="5A3zrrwZwE6IaVtS0_p5zA" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0201" />
-                <Parameter id="UxAPhbRL6EWgVIxrNws9Hw" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.33" />
-                <Parameter id="_tNnY3rE2kWEVyywUy_PtA" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0198" />
-                <Parameter id="n2Dw84zeQkSDc5ZkoFllig" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.194" />
-                <Parameter id="d7cM5B2q3UCl_ANobk_sIw" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-                <Parameter id="E_71fe9xu0i-lLQ3BzQk_A" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.207" />
-                <Parameter id="xGZBiHNZo02tAfQrNNHQLQ" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.778" />
-                <Parameter id="VCiY0O0fDkm8_nKei_tChw" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.097" />
-                <Parameter id="JhKmMpCyxEazLgSPJFo_GQ" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.788" />
-                <Parameter id="iiqTXiNK7U6YCvybObnAVQ" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.15" />
-                <Parameter id="hdu3eE__zkiFTrdQQf6axQ" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.006" />
-                <Parameter id="oF3gAu_OsEiS5hQ2GBvi7Q" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0071" />
-                <Parameter id="c0s-jC94tECnc8s-eTvEGg" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0107" />
-                <Parameter id="2y_CXHPGIUy0FkjOh8EjHQ" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0108" />
-                <Parameter id="KptcQzxpeU-SpeSORXaH4g" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.207" />
-                <Parameter id="uhB0Z4X1OkKXe8a3cAqj9g" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.23" />
-                <Parameter id="aMqbSfalEk-6okyQ3_gGwQ" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.355" />
-                <Parameter id="7eyHie891ESG8pnwbLafRA" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.75" />
-                <Parameter id="Cog-ILNAnkKjYoQKsmnYVg" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.003" />
-                <Parameter id="-OaIXooW1EC2Qkhd2YlbQg" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="3.18" />
-                <DistributedParameter id="sLjQpROATEOKEUmp3VlvYQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="iaDvgrR2PEOQ0wfw8C3SjA" mode="Logical" visible="1" displayUnit="l">
-                  <Children>
-                    <Parameter id="i9KplQC4hEyxp7c-4Igedw" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.344209121610018" displayUnit="l" />
-                    <Parameter id="j0TR_ZLgDUe6jycFIYhKhQ" name="Mean" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" value="0.196099207667264" displayUnit="l" />
-                    <Parameter id="XqLFpmF_rkKUPDRypbQ8nQ" name="GeometricDeviation" description="Geometric standard deviation of LogNormal distribution" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1.5" />
-                  </Children>
-                </DistributedParameter>
-                <DistributedParameter id="6PYyPupqpEKnII_kkziBsA" name="Specific blood flow rate" description="Blood flow rate normalized to the organ volume" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" formula="7inVHxlxU0Wq9iXjUEuc7g" mode="Logical" visible="1" displayUnit="ml/min/100g organ">
-                  <Children>
-                    <Parameter id="brgGaqu_40uRe5jIRlVxEQ" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" displayUnit="ml/min/100g organ" />
-                    <Parameter id="yN6i9sgIGk-WT7CRtCnwOQ" name="Mean" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" visible="0" canBeVaried="1" value="0.801125" displayUnit="ml/min/100g organ" />
-                    <Parameter id="MCarajMiDUm5qWsZ-vMgEA" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" visible="0" canBeVaried="1" value="0.04005625" displayUnit="ml/min/100g organ" />
-                  </Children>
-                </DistributedParameter>
-                <Container id="K3klVlojjUGDpUNjF0hcjQ" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Portal Vein Supplying Organ" />
-                    <Tag value="Spleen" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="zCMduD9likO3iFkJ-bMdng" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="Bvi6N9MmAUupsM6loHpOzw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Container id="uoQe6zsIlkiKsKwZO_OaXg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Children>
-                        <Parameter id="iNJYc1-ToUiU_HR0tia4WA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                        <Parameter id="-C397MP_Gka9uW5EA9uAIg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" visible="0" canBeVaried="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="UpAw1d6XKEShunReyqujGw" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Portal Vein Supplying Organ" />
-                    <Tag value="Spleen" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="5qkOFNXV4UeNv1NUk7ERHQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="t07-lB1pAk6YiwbGrXUo_w" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Container id="0MJbvgzPzkmxwdcXKVBZ5Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Children>
-                        <Parameter id="veeWaZK5yUqOBJNhkJJcSg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" visible="0" canBeVaried="0" />
-                        <Parameter id="er0Y5ldzXUWT2J2XQTkLGA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="n28oBqPjfEuopxshjAxU9g" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Portal Vein Supplying Organ" />
-                    <Tag value="Spleen" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="sr5-lW63okGUoCVaVrD30Q" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="LdnxzNCjoEqdHTdz6LyRvA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Parameter id="cj_Ia1-AQ0O0pQkQhQFP9g" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Individual_PKSim.PARAM_pH_INT" visible="1" canBeVaried="1" />
-                    <Container id="y9kYUGZPJU2WvboIgIYAvQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Children>
-                        <Parameter id="rbVGuF4vP0e1s-dnPBL4rQ" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                        <Parameter id="AevMu9WE4Eyw_2qYPWx17A" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_spl" visible="0" canBeVaried="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="7eQFdGd0SE2W5WJgJiG4iQ" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Portal Vein Supplying Organ" />
-                    <Tag value="Spleen" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="ML-HRHo1JE-srCrKushM3A" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="oyXiwSwOrkSsr0GORSjQxg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Parameter id="a1t6kKRUIUKPKVDN6mt3Uw" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7" />
-                    <Container id="Wu5buaE1Vkm3_sGKcgsJuA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Children>
-                        <Parameter id="tG42ut48fUuvZN27qEnsvw" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CompoundCommon.PARAM_OntogenyFactor_FromGlobal" visible="0" canBeVaried="0" />
-                        <Parameter id="DRXMhPjgoE-egAQV9adPEg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_spl" visible="0" canBeVaried="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-              </Children>
-            </Container>
-            <Container id="We5AyokJIk2r_vmUMQlpkg" name="Saliva" description="Saliva: sampling compartment, not effective for total mass balance" mode="Logical" containerType="Organ">
-              <Children>
-                <Parameter id="bSrupex8xk-gLmYVZflJRQ" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="Individual_PKSim.PARAM_Tissue_Weight" visible="0" canBeVaried="1" displayUnit="kg" />
-                <Parameter id="DwXUfn3UQUKmOfs9Blk8cQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="Individual_PKSim.VOLUME_Saliva_Organ" visible="1" canBeVaried="1" displayUnit="l" />
-                <Parameter id="yADApjnQBEaXcafqoMtCyg" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                <Parameter id="CUXHIqFqukaTqI7KIz88dg" name="Saliva flow rate" description="Saliva flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" visible="1" canBeVaried="1" value="0.001" displayUnit="l/min" />
-                <Container id="Y9x7Yqgw4kqi-ZOSL-ZiHA" name="Saliva" description="Saliva: sampling compartment, not effective for total mass balance" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Saliva" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="S5awgNlYFEm653emyfbBxQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_slv_slv" visible="0" canBeVaried="1" displayUnit="l" />
-                    <Parameter id="aSKpp3V6gUiiCOgs4cnFSQ" name="pH (saliva)" description="pH of saliva" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.4" />
-                    <Container id="_iQbJw0GLUmsNmNqi4ysFA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule" />
-                  </Children>
-                </Container>
-                <Container id="ByAZ3RX62UmGo8ITt8ggeQ" name="SalivaGland" description="Salivary Gland" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Saliva" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="Q_Zvn1IU_kyudKu7m5iPFA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CompartmentsVolume_4Comp.VOLUME_slv_slv" visible="0" canBeVaried="1" displayUnit="l" />
-                    <Container id="S7QV4Wnd6ECwFz0k-cofrg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule" />
-                  </Children>
-                </Container>
-              </Children>
-            </Container>
-          </Children>
-        </Container>
-        <Container id="8FTgFpUOE0uE6YT5jSJfVg" name="Events" description="Parent container for all non-application events" mode="Logical" containerType="Other" />
-      </TopContainers>
-      <NeighborhoodsContainer id="2sHoxZbRZUikbO7_SjXlOg" name="Neighborhoods" description="Neighborhoods" mode="Logical" containerType="Other">
-        <Children>
-          <NeighborhoodBuilder id="HlPlyd1WF0yV9grONC8b4A" name="VenousBlood_pls_VenousBlood_bc" description="Neighborhood between Venous Blood/Plasma and Venous Blood/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="AsKjCr0qtU6a-XJrIrGPTA" secondNeighbor="tLK5A0Qv_EaJTZDJ7FqJQA">
-            <Tags>
-              <Tag value="Neighborhood: Plasma / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="9K9khaGE_EyJhF2KSoCQ_g" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              <Parameter id="ualPt6sbwE-oTRIEO0lYAg" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls_Blood_Organ" visible="1" canBeVaried="1" displayUnit="cm²" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="TMkqYoRUCkq7X6dQcyD9ww" name="VenousBlood_pls_Lung_pls" description="Neighborhood between Venous Blood/Plasma and Lung/Plasma" mode="Logical" containerType="Other" firstNeighbor="AsKjCr0qtU6a-XJrIrGPTA" secondNeighbor="S9nTwpXAk0mjoLYsPZDHhA">
-            <Tags>
-              <Tag value="Neighborhood: Plasma / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="R2kt5NYdrEmkkwRc51qTBw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="YlP05iZUFkynESqIdlG6KQ" name="VenousBlood_bc_Lung_bc" description="Neighborhood between Venous Blood/Blood Cells and Lung/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="tLK5A0Qv_EaJTZDJ7FqJQA" secondNeighbor="sntQYIleCUO8SGMqvmOx9A">
-            <Tags>
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="odXLIOemgU2iL6vrQGOeVA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="3o5LgF-xvkm4dKEa-YIFdg" name="ArterialBlood_pls_ArterialBlood_bc" description="Neighborhood between Arterial Blood/Plasma and Arterial Blood/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="B0yJEO0-kUqHLgCh369ADQ" secondNeighbor="BuQVS6yXyUaIq4-4XAWfSA">
-            <Tags>
-              <Tag value="Neighborhood: Plasma / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="IelXODjUlU2OG_gwM1AJZA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              <Parameter id="GsRpHAKWNE6J_idkfIWv3Q" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls_Blood_Organ" visible="1" canBeVaried="1" displayUnit="cm²" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="1RI9wIQ3CEOII4GL8UwL0Q" name="Bone_pls_VenousBlood_pls" description="Neighborhood between Bone/Plasma and Venous Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="5qhBG-74sEmSAgcDLdsKOw" secondNeighbor="AsKjCr0qtU6a-XJrIrGPTA">
-            <Tags>
-              <Tag value="Neighborhood: Plasma / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="KGBa8_I-GEe_qW4uMa9jsw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
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-            <Tags>
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-              <Container id="HH7yPiYVxkWQjXRsAMEBNw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
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-            <Tags>
-              <Tag value="Neighborhood: Plasma / BloodCells" />
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-              <Container id="wVQHaQtBxE66Pc2PPHf5sw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
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-              <Container id="rKo7X7fAGku6_OIohbgMBQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
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-                  <Parameter id="MwyocZ94Y0a8rm1q0M9MVw" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" visible="1" canBeVaried="1" />
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-              <Parameter id="t03Sd1u4N0mwyjq3-R_5HA" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_bon" visible="1" canBeVaried="1" displayUnit="cm²" />
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-              <Tag value="Neighborhood: Plasma / BloodCells" />
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-              <Container id="t3HCp9Z66kaGVrEwMGKcMQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              <Parameter id="7L-0JgkwMUq-NId7axd3AA" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" visible="1" canBeVaried="1" displayUnit="cm²" />
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-            <Tags>
-              <Tag value="Neighborhood: Interstitial / Intracellular" />
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-            <Children>
-              <Container id="mkSLQ4DtFEqCHo_iOB8SCg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="rbDwFO1a-0ynJmd4f9bKwA" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" visible="1" canBeVaried="1" displayUnit="cm/min" />
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-                  <Parameter id="qg1rTWpQqUG_AKZwPkpv9g" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" visible="0" canBeVaried="1" displayUnit="l/min" />
-                  <Parameter id="u0SPcbr-mUqfTfUliS02EQ" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" visible="0" canBeVaried="1" displayUnit="l/min" />
-                  <Parameter id="-5rwWsB3f0yukLqweNNh2A" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" visible="0" canBeVaried="1" />
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-                  <Parameter id="3XuP61RBPkmWSdi1YB3fEg" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" visible="1" canBeVaried="1" />
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-              <Parameter id="ms567fSF4EaVEbso_i9VTQ" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_brn" visible="1" canBeVaried="1" displayUnit="cm²" />
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-              <Container id="--qP4Lj2kkOr0NtTsaEGtw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
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-            <Tags>
-              <Tag value="Neighborhood: Plasma / Interstitial" />
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-              <Container id="TUAlmx3uWkeWX3kzWbmTxg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
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-                  <Parameter id="nz2ITe1ZxEmIOygswoZ-EQ" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="DiffusionPlasma_PKSim.PARAM_P_endothelial_Brain" visible="1" canBeVaried="1" displayUnit="cm/min" />
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-              <Parameter id="_WcfViQKek66cY-Of-P36Q" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" visible="1" canBeVaried="1" displayUnit="cm²" />
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-            <Tags>
-              <Tag value="Neighborhood: Plasma / Plasma" />
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-              <Container id="XuAhywdps0mjVwnPXyXxtg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
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-            <Tags>
-              <Tag value="Neighborhood: Plasma / BloodCells" />
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-            <Children>
-              <Container id="SP-uinmeXkCawMAgxdW9CQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              <Parameter id="SJpc6DUlrUymZOhxQntkIg" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" visible="1" canBeVaried="1" displayUnit="cm²" />
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-            <Tags>
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-            <Children>
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-                  <Parameter id="chTgUS7CFUOvKTkCraLjOw" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" visible="1" canBeVaried="1" />
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-              <Parameter id="eRnvQdhjnUuDfl5nWUeYsg" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_fat" visible="1" canBeVaried="1" displayUnit="cm²" />
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-            <Tags>
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
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-            <Children>
-              <Container id="Z-iWQZACmU68Jz4kurc0WA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
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-            <Tags>
-              <Tag value="Neighborhood: Plasma / Interstitial" />
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-            <Children>
-              <Container id="0PDapgv_9UaJvsjkCkdJow" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="VcU64oblS0SLh_fUnWP2Ug" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" visible="1" canBeVaried="1" value="10" displayUnit="cm/min" />
-                  <Parameter id="yEsiBj6lykaiTTFaAWSI2w" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" visible="1" canBeVaried="1" />
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-              <Parameter id="apsKV40T2EOPO0sIR1GBMg" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" visible="1" canBeVaried="1" displayUnit="cm²" />
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-            <Tags>
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
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-            <Children>
-              <Container id="VUkMExalMEWs8jElMP_7eQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
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-          <NeighborhoodBuilder id="J4KC9uGGHE27OrzpZLMqXg" name="Gonads_pls_VenousBlood_pls" description="Neighborhood between Gonads/Plasma and Venous Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="WeKcMw4iF0S7FmaFEOg7rA" secondNeighbor="AsKjCr0qtU6a-XJrIrGPTA">
-            <Tags>
-              <Tag value="Neighborhood: Plasma / Plasma" />
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-            <Children>
-              <Container id="0SxMRLLHTk2pyqr_ppnVUQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
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-            <Tags>
-              <Tag value="Neighborhood: Plasma / Interstitial" />
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-            <Children>
-              <Container id="IRfQl3VyfkGiAwuq8FHRzQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="_cIctzfOY0qoszhZfbCuJQ" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" visible="1" canBeVaried="1" value="10" displayUnit="cm/min" />
-                  <Parameter id="FT0o8mUBCUO3390tn1KcuQ" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" visible="1" canBeVaried="1" />
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-              </Container>
-              <Parameter id="u92LstQzZUenxf7QPvtmMQ" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" visible="1" canBeVaried="1" displayUnit="cm²" />
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-              <Tag value="Neighborhood: Plasma / BloodCells" />
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-              <Container id="Fmm93m9qL0OveAV98Ztj8Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              <Parameter id="HPpn6nI1H0eFOuPUnp1YSg" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" visible="1" canBeVaried="1" displayUnit="cm²" />
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-              <Container id="OgX6VXj0xkqtj5WCOv4pAQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
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-                  <Parameter id="6RlYzaxtcEmGbBrdLItFyg" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" visible="1" canBeVaried="1" />
-                  <Parameter id="QgnAmjI-B0iM7S4ltEztog" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" visible="0" canBeVaried="1" />
-                  <Parameter id="g7Z5Gmo9skexJ9lkvHSlrg" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" visible="0" canBeVaried="1" displayUnit="l/min" />
-                  <Parameter id="0MR6fz1R0k-TOrXdnlZLVQ" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                  <Parameter id="CexwKCwyRUGQXwyZH4OQjQ" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" visible="0" canBeVaried="1" displayUnit="l/min" />
-                  <Parameter id="QjRH5qkfA0utaQqkhm1aaw" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" visible="1" canBeVaried="1" displayUnit="cm/min" />
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-              <Parameter id="ZPgnkg0JbUueyUM5LXOm6A" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_tes" visible="1" canBeVaried="1" displayUnit="cm²" />
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-          <NeighborhoodBuilder id="ER-Mez7dnkKl3zmiFzkdKg" name="Heart_bc_VenousBlood_bc" description="Neighborhood between Heart/Blood Cells and Venous Blood/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="2ChqB3XlJECSWoT4xWUL4g" secondNeighbor="tLK5A0Qv_EaJTZDJ7FqJQA">
-            <Tags>
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
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-            <Children>
-              <Container id="9jL2P2GgsUCcyiqg8nXNwg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
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-          <NeighborhoodBuilder id="oJLvyws1fU6XRsChwbjHlA" name="Heart_int_Heart_cell" description="Neighborhood between Heart/Interstitial and Heart/Intracellular" mode="Logical" containerType="Other" firstNeighbor="_MdcEmv4h0Gvl-1SRpASXg" secondNeighbor="VCB9eB3pKUCP3lOkO16geQ">
-            <Tags>
-              <Tag value="Neighborhood: Interstitial / Intracellular" />
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-            <Children>
-              <Container id="CW8QoogHdUu4LSkVHy9dOQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="KFj5ltl1dUyZFV6UQA1yIg" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" visible="1" canBeVaried="1" displayUnit="cm/min" />
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-                  <Parameter id="wrf7q1FIyEeR3qo1pDrp8A" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" visible="0" canBeVaried="1" displayUnit="l/min" />
-                  <Parameter id="eo4Jm15480GTJPH8G0CsoQ" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" visible="0" canBeVaried="1" displayUnit="l/min" />
-                  <Parameter id="pZ4_exhdokSu1ZjRZLgH3Q" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" visible="0" canBeVaried="1" />
-                  <Parameter id="RpbInYorrUqNv3l9ydSsYQ" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" visible="0" canBeVaried="1" />
-                  <Parameter id="5AP9cJCFEk2hF1fPKPgzjQ" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" visible="1" canBeVaried="1" />
-                  <Parameter id="XXvH-WUXYkerX8r8JKI4Nw" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" visible="0" canBeVaried="1" />
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-              <Parameter id="ZgSvQ9Q22kGr8JNdws7BzA" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_hrt" visible="1" canBeVaried="1" displayUnit="cm²" />
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-          <NeighborhoodBuilder id="KdQAKaECkUa9MYVT8p764w" name="Heart_pls_Heart_bc" description="Neighborhood between Heart/Plasma and Heart/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="8FF9S5dtNES_fI7J-tqAmQ" secondNeighbor="2ChqB3XlJECSWoT4xWUL4g">
-            <Tags>
-              <Tag value="Neighborhood: Plasma / BloodCells" />
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-            <Children>
-              <Container id="4Rjm51r24EKjPjzcgSFf6w" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              <Parameter id="IpP_uZUY5kuDDmJoVfFZhA" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" visible="1" canBeVaried="1" displayUnit="cm²" />
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-          <NeighborhoodBuilder id="8i9hsc-P9kuhwDrLmdgkzQ" name="Heart_pls_Heart_int" description="Neighborhood between Heart/Plasma and Heart/Interstitial" mode="Logical" containerType="Other" firstNeighbor="8FF9S5dtNES_fI7J-tqAmQ" secondNeighbor="_MdcEmv4h0Gvl-1SRpASXg">
-            <Tags>
-              <Tag value="Neighborhood: Plasma / Interstitial" />
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-            <Children>
-              <Container id="4WdkoDciX02yK7jDk9QkHA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="Xe_vsd9g5k-5YSC13r5LnQ" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" visible="1" canBeVaried="1" value="10" displayUnit="cm/min" />
-                  <Parameter id="FAu32f1ir0yPmrSHJb-jAw" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" visible="1" canBeVaried="1" />
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-              <Parameter id="RqKPrvbC6k67RghWw5gozg" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" visible="1" canBeVaried="1" displayUnit="cm²" />
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-            <Tags>
-              <Tag value="Neighborhood: Plasma / Plasma" />
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-            <Children>
-              <Container id="KAXyUgyHSUaCruXA4oZmpg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
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-            <Tags>
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
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-            <Children>
-              <Container id="OHcP2gn03k2XitGw_F3jEg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
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-            <Tags>
-              <Tag value="Neighborhood: Interstitial / Intracellular" />
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-            <Children>
-              <Container id="ABMS2EIuCkyUqE-q9Mt9qQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="MhhM9ctbIka8Q7lkXv83RA" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" visible="0" canBeVaried="1" />
-                  <Parameter id="8rsJK98QvkmlLqixsZ7EcQ" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                  <Parameter id="dXoBM-5M7E2yzEHw6268iw" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                  <Parameter id="qtRcPeFZpUamMWupvHbCQQ" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" visible="0" canBeVaried="1" displayUnit="l/min" />
-                  <Parameter id="DkH8S4GbrEqxxf7w4OF1TA" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" visible="0" canBeVaried="1" />
-                  <Parameter id="2v6o6KCrJk-_aF7DTGwXfw" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" visible="1" canBeVaried="1" />
-                  <Parameter id="xvC1_l3S90a6BzPESQZ3JA" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" visible="0" canBeVaried="1" />
-                  <Parameter id="y6r7HXKiIkCYIMBEBLLAeA" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" visible="0" canBeVaried="1" displayUnit="l/min" />
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-              <Parameter id="2uciSJRaW0WbJAGIl8RxYg" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_kid" visible="1" canBeVaried="1" displayUnit="cm²" />
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-          <NeighborhoodBuilder id="0I_6S4CTHk6HhKgoiLc1Dw" name="Kidney_cell_Kidney_ur" description="Neighborhood between Kidney/Intracellular and Kidney/Urine" mode="Logical" containerType="Other" firstNeighbor="eLf8CEl_NUi-dMAposbfrA" secondNeighbor="o6ozB8VQSky3KivzfiFkuQ">
-            <Tags>
-              <Tag value="Neighborhood: Intracellular / Urine" />
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-            <Children>
-              <Container id="A02tFKrqH0SfxUEIrASTEQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="2O4MOCCBuUGGtFpeN6bpkw" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_water_cell_Kidney" visible="0" canBeVaried="1" />
-                </Children>
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-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="5ba1q8dwN0GJgN6a39rHHw" name="Kidney_pls_Kidney_bc" description="Neighborhood between Kidney/Plasma and Kidney/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="vNliK8ccZ0mhuF90e6m6Sw" secondNeighbor="8zPkGeGmU0OEOAd4v6wLwA">
-            <Tags>
-              <Tag value="Neighborhood: Plasma / BloodCells" />
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-            <Children>
-              <Container id="zx22k_8xzEWXgBD8mVJ3Tg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              <Parameter id="_0ds6Ghi50GflliaLKPG-w" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" visible="1" canBeVaried="1" displayUnit="cm²" />
-            </Children>
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-          <NeighborhoodBuilder id="-Gjmn5DaLE2P8EdUf5mM-Q" name="Kidney_pls_Kidney_int" description="Neighborhood between Kidney/Plasma and Kidney/Interstitial" mode="Logical" containerType="Other" firstNeighbor="vNliK8ccZ0mhuF90e6m6Sw" secondNeighbor="Lowod1S6EUOQfh9G0nlt1A">
-            <Tags>
-              <Tag value="Neighborhood: Plasma / Interstitial" />
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-            <Children>
-              <Container id="o8ddjkg1kUW3bFxQREv9BQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="HoEbThd_8UWw16uYyw5pGA" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" visible="1" canBeVaried="1" value="10" displayUnit="cm/min" />
-                  <Parameter id="kP6z1evQYEWvfL0eEx0J0g" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" visible="1" canBeVaried="1" />
-                </Children>
-              </Container>
-              <Parameter id="pqaRKdynz0u1380gDWBOAQ" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" visible="1" canBeVaried="1" displayUnit="cm²" />
-            </Children>
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-          <NeighborhoodBuilder id="V6xp45iaJE-VGxUxjPsX7w" name="Kidney_pls_Kidney_ur" description="Neighborhood between Kidney/Plasma and Kidney/Urine" mode="Logical" containerType="Other" firstNeighbor="vNliK8ccZ0mhuF90e6m6Sw" secondNeighbor="o6ozB8VQSky3KivzfiFkuQ">
-            <Tags>
-              <Tag value="Neighborhood: Plasma / Urine" />
-            </Tags>
-            <Children>
-              <Container id="pG-w2ivSiUCqXlvFrPDrMA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="ZcK8xCp5MU-Dc_onXjqnLg" name="UpperJejunum_pls_PortalVein_pls" description="Neighborhood between Upper Jejunum/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="BfP4xKdBX0SaUMpMCDXvbg" secondNeighbor="-btXNr8mOEG_8ZCjsspLow">
-            <Tags>
-              <Tag value="Neighborhood: Plasma / Plasma" />
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-            <Children>
-              <Container id="Pum-q89AukW0figBf6w6CA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="ZMefrTJilE2NNAQAjUBOng" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPvePlasma" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                </Children>
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-            </Children>
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-          <NeighborhoodBuilder id="wfLtidEgok-oujKmwQOA1A" name="Lumen_uje_UpperJejunum_cell" description="Neighborhood between Lumen/Upper Jejunum and Mucosa/Upper Jejunum/Intracellular" mode="Logical" containerType="Other" firstNeighbor="yZg5exSq8EiErExr7X9h7A" secondNeighbor="kUFeS_kjtUW66GnJH4ZzKg">
-            <Tags>
-              <Tag value="Neighborhood: UpperJejunum / Intracellular" />
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-            <Children>
-              <Container id="2lQw_8ZmaU6P7bk7YxJr9w" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="cghQAIHz8E6NNW61UxW3sg" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  <Parameter id="l4Z-gbxiVUyZwcTyMj742w" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  <Parameter id="HKaedLawfECfYOE_zSgKfA" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K6" visible="0" canBeVaried="0" />
-                  <Parameter id="lCtpf2mP-Ea2mhukW49TzA" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K5" visible="0" canBeVaried="0" />
-                  <Parameter id="4Vugm3GJN0eMvVcVKbAjRg" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_DrugAbsorption_trans" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  <Parameter id="KgD7p8OoVUe6Bh8FswPhNw" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_cell_lum_factor" visible="0" canBeVaried="0" />
-                  <Parameter id="kUHVUCdpQUGiO3YFDZnk3Q" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_lum_cell_factor" visible="0" canBeVaried="0" />
-                  <Parameter id="q0QVei_ceUGiry9FXLufMw" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Lumen_PKSim.PARAM_K_cell_pls_UpperJejunum" visible="0" canBeVaried="0" />
-                  <Parameter id="mZo5Ws8NW0yHp1j0gNEhyw" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_UpperJejunum" visible="0" canBeVaried="1" />
-                  <Parameter id="WtN8iGMyFECXM5A8XwJL9A" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F1" visible="0" canBeVaried="0" />
-                  <Parameter id="OZsUePWtYkWAlDRsS5mQ9Q" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F2" visible="0" canBeVaried="0" />
-                  <Parameter id="Lw1jwcsfjkuVeyS87BChmw" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F3" visible="0" canBeVaried="0" />
-                  <Parameter id="CjE2AEK0nEaEA2Whbm5RFw" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K1" visible="0" canBeVaried="0" />
-                  <Parameter id="HRYNtkoJYUKukxEoVhKVcg" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K2" visible="0" canBeVaried="0" />
-                  <Parameter id="LV8kU90eKU-jl3m_WsKP4g" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K8" visible="0" canBeVaried="0" />
-                  <Parameter id="iop906MAAEGgk7FkFl_pWQ" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K4" visible="0" canBeVaried="0" />
-                  <Parameter id="92SvCK4f3EKt3F1eskOpNw" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K7" visible="0" canBeVaried="0" />
-                  <Parameter id="FoagA8EZD0mlio39gehIHw" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K6" visible="0" canBeVaried="0" />
-                  <Parameter id="h1KJISJJHUKkrIqfKxojmw" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K7" visible="0" canBeVaried="0" />
-                  <Parameter id="Uk7eq5T9skihd3Jx-uJ6ng" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K8" visible="0" canBeVaried="0" />
-                  <Parameter id="3XWNnUFLqk6PCqwobp1DEg" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F1" visible="0" canBeVaried="0" />
-                  <Parameter id="PkGmBs9MxkK-Zk3ZuEXjOA" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F2" visible="0" canBeVaried="0" />
-                  <Parameter id="0nle1JhH7UaK4Mlj3tm3tA" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F3" visible="0" canBeVaried="0" />
-                  <Parameter id="ZM-ZLyV84kq0VPZvYSzvtA" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K1" visible="0" canBeVaried="0" />
-                  <Parameter id="hxAj7dzKx0S1C5_Wv0uiog" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K2" visible="0" canBeVaried="0" />
-                  <Parameter id="GWPhEtEWJUObXBAmGiRbQQ" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K3" visible="0" canBeVaried="0" />
-                  <Parameter id="LMxncQf8kUiR4HO7u1Idyw" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K4" visible="0" canBeVaried="0" />
-                  <Parameter id="ESt_aJc5s0KFRw-muxtULw" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K5" visible="0" canBeVaried="0" />
-                  <Parameter id="pyBpaam01kqgnHfA8ScVCg" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K3" visible="0" canBeVaried="0" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="gFZG4bXDnk2ayskbCxF7Lw" name="Lumen_uje_UpperJejunum_pls" description="Neighborhood between Lumen/Upper Jejunum and Mucosa/Upper Jejunum/Plasma" mode="Logical" containerType="Other" firstNeighbor="yZg5exSq8EiErExr7X9h7A" secondNeighbor="BfP4xKdBX0SaUMpMCDXvbg">
-            <Tags>
-              <Tag value="Neighborhood: UpperJejunum / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="i3r5fSECoUSPGxU_UNyTAQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="kpo4qaSgrEuYCE2BqSJGbg" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_DrugAbsorption_para" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  <Parameter id="jbQZKJrMFkmFMrkiAj-p7g" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  <Parameter id="dmbUfgKNqkuhXh0u237ltQ" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="da4aMbuuxEOuomJOpKBisg" name="UpperJejunum_bc_PortalVein_bc" description="Neighborhood between Upper Jejunum/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="Ej30rRxCREi_lFbIacWhBg" secondNeighbor="ghMacG-81kSUPN5wkgPsnA">
-            <Tags>
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="7r1bla8ahkex9__-4YG6IQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="GfBgsNfvKUqgA5TPmUomYg" name="Mass transfer rate (mucosa to portal vein blood cells)" description="Mass transfer rate (mucosa to portal vein blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPveBloodCells" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="2M2dTvKZUkCAI9nHyTSyqw" name="Kidney_pls_VenousBlood_pls" description="Neighborhood between Kidney/Plasma and Venous Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="vNliK8ccZ0mhuF90e6m6Sw" secondNeighbor="AsKjCr0qtU6a-XJrIrGPTA">
-            <Tags>
-              <Tag value="Neighborhood: Plasma / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="69dQrQu1qkmMfOoDf14t4Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="CqeMRXubhUCZe_13INWPyA" name="Lumen_uil_Lumen_lil" description="Neighborhood between Lumen/Upper Ileum and Lumen/Lower Ileum" mode="Logical" containerType="Other" firstNeighbor="GllsaRsHZUOo1T5JiPknaA" secondNeighbor="vCPS2yMfPkKIhDcs0uJgFQ">
-            <Tags>
-              <Tag value="Neighborhood: UpperIleum / LowerIleum" />
-            </Tags>
-            <Children>
-              <Container id="DtfoWXyWW0S5ubdh0f85BA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="fHK4MWhsKEuFbpOct2OXnA" name="Lumen_sto_Lumen_duo" description="Neighborhood between Lumen/Stomach and Lumen/Duodenum" mode="Logical" containerType="Other" firstNeighbor="UmGxOEHQ7kGDntzb_Y39tw" secondNeighbor="B2SJL0T_506x1Wlk3TTamQ">
-            <Tags>
-              <Tag value="Neighborhood: Stomach / Duodenum" />
-            </Tags>
-            <Children>
-              <Container id="83VR44eHUUeDU7v2q-Ibww" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="uO7nFddRYUeDMPUP9-eRcA" name="Oral mass absorbed" description="Oral mass absorbed from Lumen into mucosa" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" formula="Lumen_PKSim.PARAM_OralMassAbsorbed" visible="0" canBeVaried="0" displayUnit="µmol" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="rZsve4MWIECfB2c0ur1DkQ" name="Lumen_duo_Lumen_uje" description="Neighborhood between Lumen/Duodenum and Lumen/Upper Jejunum" mode="Logical" containerType="Other" firstNeighbor="B2SJL0T_506x1Wlk3TTamQ" secondNeighbor="yZg5exSq8EiErExr7X9h7A">
-            <Tags>
-              <Tag value="Neighborhood: Duodenum / UpperJejunum" />
-            </Tags>
-            <Children>
-              <Container id="n0jjdwJvb0alx2L06W5YiQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="1suiObw0gEOGgfieHI7fQw" name="Lumen_lje_Lumen_uil" description="Neighborhood between Lumen/Lower Jejunum and Lumen/Upper Ileum" mode="Logical" containerType="Other" firstNeighbor="ZDiugimqaEynDJbV3Eje2g" secondNeighbor="GllsaRsHZUOo1T5JiPknaA">
-            <Tags>
-              <Tag value="Neighborhood: LowerJejunum / UpperIleum" />
-            </Tags>
-            <Children>
-              <Container id="17hJF6DGu0ebn4NANDbqKA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="umn1JjXWxECjDpYL73yXSQ" name="LowerJejunum_bc_PortalVein_bc" description="Neighborhood between Lower Jejunum/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="JvhcU5G9sESOfI0HQ9iySg" secondNeighbor="ghMacG-81kSUPN5wkgPsnA">
-            <Tags>
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="2LX37BIB2Eaf3M_DSXWMCQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="95210DqeZU26uDLDPVP8YA" name="Mass transfer rate (mucosa to portal vein blood cells)" description="Mass transfer rate (mucosa to portal vein blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPveBloodCells" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="Oez18RfCBkmtbT7XFNDlXg" name="Lumen_lil_Lumen_cae" description="Neighborhood between Lumen/Lower Ileum and Lumen/Cecum" mode="Logical" containerType="Other" firstNeighbor="vCPS2yMfPkKIhDcs0uJgFQ" secondNeighbor="sk41NH_8KEi_nNbtDlGvFA">
-            <Tags>
-              <Tag value="Neighborhood: LowerIleum / Caecum" />
-            </Tags>
-            <Children>
-              <Container id="VNA1vEs7oEK-F6frGkWQhw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="E6Bneiygb0imugiHDJJYDA" name="Lumen_rect_Lumen_fec" description="Neighborhood between Lumen/Rectum and Lumen/Feces" mode="Logical" containerType="Other" firstNeighbor="tl7DiBQWEUGwcvPUXLf68w" secondNeighbor="bhSAzpl7HkaX9dPtBlqhGQ">
-            <Tags>
-              <Tag value="Neighborhood: Rectum / Feces" />
-            </Tags>
-            <Children>
-              <Container id="wLjpHgk4x0WyAIDWYainpg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="0BarMzds00y8D-PhEaW16w" name="Lumen_colasc_Lumen_coltrans" description="Neighborhood between Lumen/Colon Ascendens and Lumen/Colon Transversum" mode="Logical" containerType="Other" firstNeighbor="xYyLHo4Vhk6D6RJrPpFicA" secondNeighbor="EhWe8Xqa6EKqp-YjJgQUiw">
-            <Tags>
-              <Tag value="Neighborhood: ColonAscendens / ColonTransversum" />
-            </Tags>
-            <Children>
-              <Container id="0fohY052rkeTRpbEg6_klw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="-ByF8Ho_B0izlH2AyQFvLA" name="Lumen_coltrans_Lumen_coldesc" description="Neighborhood between Lumen/Colon Transversum and Lumen/Colon Descendens" mode="Logical" containerType="Other" firstNeighbor="EhWe8Xqa6EKqp-YjJgQUiw" secondNeighbor="TQQ1m1iJG0CQmvlfvaPkuA">
-            <Tags>
-              <Tag value="Neighborhood: ColonTransversum / ColonDescendens" />
-            </Tags>
-            <Children>
-              <Container id="LXcWeAjZD0K6kpncCUQVIg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="DORJxgo19EKj_4vGMPI9Nw" name="Lumen_coldesc_Lumen_colsigm" description="Neighborhood between Lumen/Colon Descendens and Lumen/Colon Sigmoid" mode="Logical" containerType="Other" firstNeighbor="TQQ1m1iJG0CQmvlfvaPkuA" secondNeighbor="pXPUliiKakqWhra3psEI6A">
-            <Tags>
-              <Tag value="Neighborhood: ColonDescendens / ColonSigmoid" />
-            </Tags>
-            <Children>
-              <Container id="fuSRswCUMU-nbYO7gDYKhw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="YgUHYZN0eky5ZRyyaSJ3yw" name="Lumen_colsigm_Lumen_rect" description="Neighborhood between Lumen/Colon Sigmoid and Lumen/Rectum" mode="Logical" containerType="Other" firstNeighbor="pXPUliiKakqWhra3psEI6A" secondNeighbor="tl7DiBQWEUGwcvPUXLf68w">
-            <Tags>
-              <Tag value="Neighborhood: ColonSigmoid / Rectum" />
-            </Tags>
-            <Children>
-              <Container id="LsyjstcR2UiVW_dCfsu90g" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="Jx3VDgIKGkCdYwGqbvqNFA" name="Lumen_uje_Lumen_lje" description="Neighborhood between Lumen/Upper Jejunum and Lumen/Lower Jejunum" mode="Logical" containerType="Other" firstNeighbor="yZg5exSq8EiErExr7X9h7A" secondNeighbor="ZDiugimqaEynDJbV3Eje2g">
-            <Tags>
-              <Tag value="Neighborhood: UpperJejunum / LowerJejunum" />
-            </Tags>
-            <Children>
-              <Container id="6iuuquHwKE-p7RUMTJSujw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="6NpwyImPWke2jphPRssxyw" name="Lumen_cae_Lumen_colasc" description="Neighborhood between Lumen/Cecum and Lumen/Colon Ascendens" mode="Logical" containerType="Other" firstNeighbor="sk41NH_8KEi_nNbtDlGvFA" secondNeighbor="xYyLHo4Vhk6D6RJrPpFicA">
-            <Tags>
-              <Tag value="Neighborhood: Caecum / ColonAscendens" />
-            </Tags>
-            <Children>
-              <Container id="UJRQKVvp4Ui09oE3-vWI6A" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="dLhqv-IB2k-BgRhyzxFw0g" name="Lumen_lje_LowerJejunum_pls" description="Neighborhood between Lumen/Lower Jejunum and Mucosa/Lower Jejunum/Plasma" mode="Logical" containerType="Other" firstNeighbor="ZDiugimqaEynDJbV3Eje2g" secondNeighbor="1XxBZvONAEWWEWN1gOg4VQ">
-            <Tags>
-              <Tag value="Neighborhood: LowerJejunum / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="AeYHzdTMCEOMu6irPjnUtA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="jEUY3mLp9Ue1-Gl2YQKplQ" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_DrugAbsorption_para" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  <Parameter id="88QbXc30ykSkJmrvUri7dQ" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  <Parameter id="qunkfu1AWU-AalCReQx-yA" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="-0Hsw-q1Z0exIiP46uQoBg" name="Lumen_lje_LowerJejunum_cell" description="Neighborhood between Lumen/Lower Jejunum and Mucosa/Lower Jejunum/Intracellular" mode="Logical" containerType="Other" firstNeighbor="ZDiugimqaEynDJbV3Eje2g" secondNeighbor="H45QSpDHZU6_rrF8B6S3IQ">
-            <Tags>
-              <Tag value="Neighborhood: LowerJejunum / Intracellular" />
-            </Tags>
-            <Children>
-              <Container id="eF8DNoIfS0280rmXVNsMSQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="mazT_buqn0e9QYs85kdaWg" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_DrugAbsorption_trans" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  <Parameter id="_05iY5K0JUCSL8YnnSIqKQ" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K5" visible="0" canBeVaried="0" />
-                  <Parameter id="9O2yflLuHkqkr2oIMbIW_w" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_cell_lum_factor" visible="0" canBeVaried="0" />
-                  <Parameter id="lKxFjRopFEy6bp8jkW8J4Q" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_lum_cell_factor" visible="0" canBeVaried="0" />
-                  <Parameter id="zMMa5aDxk0Wp2cEvvMyw0g" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Lumen_PKSim.PARAM_K_cell_pls_LowerJejunum" visible="0" canBeVaried="0" />
-                  <Parameter id="KyOoHKq_HU2F3M2OWpXpug" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_LowerJejunum" visible="0" canBeVaried="1" />
-                  <Parameter id="RhQJW-FWxECXNlaaWo5qlQ" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F1" visible="0" canBeVaried="0" />
-                  <Parameter id="CXSvNqsr_0et-ojQr2iwog" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F2" visible="0" canBeVaried="0" />
-                  <Parameter id="vW6IbucPBUC2YVackZj3aw" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F3" visible="0" canBeVaried="0" />
-                  <Parameter id="HtzwOXyvt0i2mXeLElXcag" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K1" visible="0" canBeVaried="0" />
-                  <Parameter id="6L9ENBdyKEmv_oGjk0HnBg" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K2" visible="0" canBeVaried="0" />
-                  <Parameter id="iDbjTUlodkGDUNeUeQnThg" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K3" visible="0" canBeVaried="0" />
-                  <Parameter id="LP_8iQhJk0G_ZAQFfOxXjg" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K6" visible="0" canBeVaried="0" />
-                  <Parameter id="dznn1tGxT0-xzd9fc5pTJg" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K4" visible="0" canBeVaried="0" />
-                  <Parameter id="yEIkYhMGN02Siq04IFqwQQ" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  <Parameter id="xbNrB9momkGT6dAajGV1EA" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K7" visible="0" canBeVaried="0" />
-                  <Parameter id="f2tBtA5aSUOIksbzTJQD4Q" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K8" visible="0" canBeVaried="0" />
-                  <Parameter id="P0kfxhfimkOFqI1lDOi8KA" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F1" visible="0" canBeVaried="0" />
-                  <Parameter id="M5KlA9z49Uu513w1b6oidg" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F2" visible="0" canBeVaried="0" />
-                  <Parameter id="NhTjz8S-LEKfSf20jwv-IA" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F3" visible="0" canBeVaried="0" />
-                  <Parameter id="2UNa2Pi-jEmxrmitsOSTaQ" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K1" visible="0" canBeVaried="0" />
-                  <Parameter id="0Mn4NSSvtkKNgHdCyuEPDQ" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K2" visible="0" canBeVaried="0" />
-                  <Parameter id="8lAM9SbC_EeQFfTZUG2ZLw" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K3" visible="0" canBeVaried="0" />
-                  <Parameter id="EhDqUtChpUuwMIbPu9-fIw" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K4" visible="0" canBeVaried="0" />
-                  <Parameter id="8II0wUjpekWPWHORvJkmZA" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K5" visible="0" canBeVaried="0" />
-                  <Parameter id="k9Bax-j0F0KKQL14Rhp6zw" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K6" visible="0" canBeVaried="0" />
-                  <Parameter id="iiaRsC28AUamzOuT9la0-w" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K8" visible="0" canBeVaried="0" />
-                  <Parameter id="uaDsiB0qbUKL5WLCr3-s4Q" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  <Parameter id="EP3qiYJog0q5qNJARtgf1A" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K7" visible="0" canBeVaried="0" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="jXI2DJQCskW6sZesS_K8GA" name="LowerJejunum_pls_PortalVein_pls" description="Neighborhood between Lower Jejunum/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="1XxBZvONAEWWEWN1gOg4VQ" secondNeighbor="-btXNr8mOEG_8ZCjsspLow">
-            <Tags>
-              <Tag value="Neighborhood: Plasma / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="SmtONG8KhE-wDQXTWvQFww" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="m0Ufvz-hKUKiKiKLkCzBkA" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPvePlasma" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="LkrZpG0wPUCiWHjBIBJv9A" name="UpperIleum_pls_PortalVein_pls" description="Neighborhood between Upper Ileum/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="agEz-d8UnU2AlENh6qiY5A" secondNeighbor="-btXNr8mOEG_8ZCjsspLow">
-            <Tags>
-              <Tag value="Neighborhood: Plasma / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="CWTNvgiiKku8H1pReH6ZVg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="waQ4tg5F90mzgTtkFGdwuA" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPvePlasma" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="x_Mx63CLC02BFZsukkRq1A" name="Stomach_pls_Stomach_bc" description="Neighborhood between Stomach/Plasma and Stomach/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="wcVwGWqUikGrxah1-6Vx6A" secondNeighbor="ZsgRGsl2Ika6nIUVelD34g">
-            <Tags>
-              <Tag value="Neighborhood: Plasma / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="DaUooU_LYECQp90ukm0HXQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              <Parameter id="b7_Bsn5DSkmKSFsKB1d1ug" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" visible="1" canBeVaried="1" displayUnit="cm²" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="SdylVoAiHEOXG4lNHXA05w" name="Stomach_pls_Stomach_int" description="Neighborhood between Stomach/Plasma and Stomach/Interstitial" mode="Logical" containerType="Other" firstNeighbor="wcVwGWqUikGrxah1-6Vx6A" secondNeighbor="pkdR9CiDHEq7nh4GTlLyVA">
-            <Tags>
-              <Tag value="Neighborhood: Plasma / Interstitial" />
-            </Tags>
-            <Children>
-              <Container id="9V-stqN1SUODxFR0QbW5vg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="EvXb4XhDkUa3tfW3vYXVbw" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" visible="1" canBeVaried="1" />
-                  <Parameter id="wsRGT_Rtsk-ifM-z8Abeyg" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" visible="1" canBeVaried="1" value="10" displayUnit="cm/min" />
-                </Children>
-              </Container>
-              <Parameter id="hPilTrXklUOKHECYizVZZw" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" visible="1" canBeVaried="1" displayUnit="cm²" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="jQ9ZntXk3E2A8CT80KreOg" name="Stomach_pls_PortalVein_pls" description="Neighborhood between Stomach/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="wcVwGWqUikGrxah1-6Vx6A" secondNeighbor="-btXNr8mOEG_8ZCjsspLow">
-            <Tags>
-              <Tag value="Neighborhood: Plasma / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="jH9fuO5R1kWw6DeNNOyw2w" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="YSE6NheLNU6wXEnn_QAC0w" name="Stomach_bc_PortalVein_bc" description="Neighborhood between Stomach/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="ZsgRGsl2Ika6nIUVelD34g" secondNeighbor="ghMacG-81kSUPN5wkgPsnA">
-            <Tags>
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="pSaOwkvMAUGTtAMaTtY0xw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="xeXqTnRf5EerJCbDxnDZxA" name="Stomach_int_Stomach_cell" description="Neighborhood between Stomach/Interstitial and Stomach/Intracellular" mode="Logical" containerType="Other" firstNeighbor="pkdR9CiDHEq7nh4GTlLyVA" secondNeighbor="Mur3m3tL10Ga-Q6Mn5phPg">
-            <Tags>
-              <Tag value="Neighborhood: Interstitial / Intracellular" />
-            </Tags>
-            <Children>
-              <Container id="1hh_eWj1m0uJoPpDPFQE1g" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="xmGG2gaikEiE7Lu37SME2Q" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                  <Parameter id="LBD0DmKVC0qv1QVqv_MeIQ" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                  <Parameter id="BkhdjZC-oE2HPCDSD1K3_Q" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" visible="0" canBeVaried="1" displayUnit="l/min" />
-                  <Parameter id="0pUdLYzBJU6DhPGiymfuYw" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" visible="0" canBeVaried="1" displayUnit="l/min" />
-                  <Parameter id="RWF8XzhP-U2UNWBTTxdoag" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" visible="0" canBeVaried="1" />
-                  <Parameter id="ajXtcO7dgEi1TS-GbI-Zkw" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" visible="0" canBeVaried="1" />
-                  <Parameter id="zHWUuu__-0ar8LABFGZumQ" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" visible="1" canBeVaried="1" />
-                  <Parameter id="WcCn5Mt0MUGjq1z5uHr3Rw" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" visible="0" canBeVaried="1" />
-                </Children>
-              </Container>
-              <Parameter id="3v2gHzTMNkKXzI_xInPnkA" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_sto" visible="1" canBeVaried="1" displayUnit="cm²" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="YEP93NNp5EWzVnNDJO0kZg" name="Lumen_uil_UpperIleum_cell" description="Neighborhood between Lumen/Upper Ileum and Mucosa/Upper Ileum/Intracellular" mode="Logical" containerType="Other" firstNeighbor="GllsaRsHZUOo1T5JiPknaA" secondNeighbor="Ei9kUV8Ht0yP_sgNxLtolg">
-            <Tags>
-              <Tag value="Neighborhood: UpperIleum / Intracellular" />
-            </Tags>
-            <Children>
-              <Container id="C-GlFMhDtU6En4CT_6OZGw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="_NGDCcfCpEqMU5ZZy-nXwg" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  <Parameter id="EqgSH6B0d02Xe5oGGYgw4g" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  <Parameter id="RO2LgOs_IkyaeDXbN5giaQ" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K8" visible="0" canBeVaried="0" />
-                  <Parameter id="FKnEXTvys0eJGan8UoM9LA" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_lum_cell_factor" visible="0" canBeVaried="0" />
-                  <Parameter id="noui1PIq2UaDQMsDZhWcgA" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Lumen_PKSim.PARAM_K_cell_pls_UpperIleum" visible="0" canBeVaried="0" />
-                  <Parameter id="9lrD9gSFNEOMmhhmIOk9_A" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_UpperIleum" visible="0" canBeVaried="1" />
-                  <Parameter id="rQ2DpVZJUEOowkTjN8yZeQ" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F1" visible="0" canBeVaried="0" />
-                  <Parameter id="2xsNoLPxAkGtTHUstiGqmw" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F2" visible="0" canBeVaried="0" />
-                  <Parameter id="nc7-DZpHdkSioLkqcLyg6A" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F3" visible="0" canBeVaried="0" />
-                  <Parameter id="E6bwfQpyBU60JKpZpPtmkg" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K1" visible="0" canBeVaried="0" />
-                  <Parameter id="2L_oFq9rS0yOT0Ou7WdYMg" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K2" visible="0" canBeVaried="0" />
-                  <Parameter id="AuS60CgYpkmYsG-5FyIccA" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K3" visible="0" canBeVaried="0" />
-                  <Parameter id="6u26OlZjkkiV_b-WFuUK3Q" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K4" visible="0" canBeVaried="0" />
-                  <Parameter id="TSAlzgIfYkeIBZpRvjAHEA" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K5" visible="0" canBeVaried="0" />
-                  <Parameter id="2mJt-c1oqkGfO-vKfyfigQ" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K7" visible="0" canBeVaried="0" />
-                  <Parameter id="VgExCFiHR0O6nuGBrZdgfA" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F1" visible="0" canBeVaried="0" />
-                  <Parameter id="s1k37O9x5Uma2GjY1M63Iw" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F2" visible="0" canBeVaried="0" />
-                  <Parameter id="o2mwJoK0LU6iYtTPtF05gg" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F3" visible="0" canBeVaried="0" />
-                  <Parameter id="XfN7Mguzd0WN85ypWO2QXw" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K1" visible="0" canBeVaried="0" />
-                  <Parameter id="5yDC15WbPUe6I-DnvGRD1Q" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K2" visible="0" canBeVaried="0" />
-                  <Parameter id="K2KTQIRTQEacbyIBybjB8w" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K3" visible="0" canBeVaried="0" />
-                  <Parameter id="Fp12hickTE6NYeBQry96tA" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K4" visible="0" canBeVaried="0" />
-                  <Parameter id="oS_9yt67VUql0tpiUKsbBw" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K5" visible="0" canBeVaried="0" />
-                  <Parameter id="2_SB8bs84U-T6mnW1NTs1A" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K6" visible="0" canBeVaried="0" />
-                  <Parameter id="y-2x-JaB0EuNLFMGKQn09g" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K7" visible="0" canBeVaried="0" />
-                  <Parameter id="8vvInMb_FU6BUqcfCrsTxA" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K8" visible="0" canBeVaried="0" />
-                  <Parameter id="N-C4B1Sh9U2fz1Lw0C-Z8g" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K6" visible="0" canBeVaried="0" />
-                  <Parameter id="7LLL09c7gkKKjwNAnOHShQ" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_cell_lum_factor" visible="0" canBeVaried="0" />
-                  <Parameter id="JIjbr4SXZUWgCuR9zw6URw" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_DrugAbsorption_trans" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                </Children>
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-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="0Xjl6YCcnUmPk5h_e4B5Zg" name="UpperIleum_bc_PortalVein_bc" description="Neighborhood between Upper Ileum/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="o2sI8fS0SkSgY4brbhcmyA" secondNeighbor="ghMacG-81kSUPN5wkgPsnA">
-            <Tags>
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="k3bbBfn6g0iOnWvpuw0wPg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="tj88thh6S0-fyUr7GXj3WQ" name="Mass transfer rate (mucosa to portal vein blood cells)" description="Mass transfer rate (mucosa to portal vein blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPveBloodCells" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="RQ7vT23n2E-GM3oWwz7zAA" name="Lumen_uil_UpperIleum_pls" description="Neighborhood between Lumen/Upper Ileum and Mucosa/Upper Ileum/Plasma" mode="Logical" containerType="Other" firstNeighbor="GllsaRsHZUOo1T5JiPknaA" secondNeighbor="agEz-d8UnU2AlENh6qiY5A">
-            <Tags>
-              <Tag value="Neighborhood: UpperIleum / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="VttZd-88d0WsHkmMnG5AAA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="ZFudx6zC1k-KLECfoiEz2g" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  <Parameter id="2LGZM-vQYka8xCZcybasBA" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_DrugAbsorption_para" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  <Parameter id="bJyQ1nbGJ0ajnukl5-CvnQ" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                </Children>
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-            </Children>
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-          <NeighborhoodBuilder id="kMoa6jEp60mOEB-Vzc_AAg" name="SmallIntestine_bc_LowerJejunum_bc" description="Neighborhood between Small Intestine/Blood Cells_ and Lower Jejunum/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="n6xwS0M17UWg01nLAvRLIQ" secondNeighbor="JvhcU5G9sESOfI0HQ9iySg">
-            <Tags>
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="n971X3VaTUagdWN4G0ZInA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="mvydYNIp60iifybuCS4bZQ" name="Mass transfer rate (intestine to mucosa blood cells)" description="Mass transfer rate (intestine to mucosa blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaBloodCells" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="8GzCNQURiU2fCK8DKjjGkg" name="SmallIntestine_pls_LowerJejunum_pls" description="Neighborhood between Small Intestine/Plasma_ and Lower Jejunum/Plasma" mode="Logical" containerType="Other" firstNeighbor="bKNuXngQSk-SQQe7D3MkAw" secondNeighbor="1XxBZvONAEWWEWN1gOg4VQ">
-            <Tags>
-              <Tag value="Neighborhood: Plasma / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="V9DuXZm2QEy2mQcInsZQaA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="0FYLPTuAa0KTezmKDq06Tw" name="Mass transfer rate (intestine to mucosa plasma)" description="Mass transfer rate (intestine to mucosa plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaPlasma" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="6p0xIl1QukW4FrHJsZBciA" name="SmallIntestine_bc_UpperIleum_bc" description="Neighborhood between Small Intestine/Blood Cells_ and Upper Ileum/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="n6xwS0M17UWg01nLAvRLIQ" secondNeighbor="o2sI8fS0SkSgY4brbhcmyA">
-            <Tags>
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="-OyEQ3WXx02-VUM7-sE7ew" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="sFy4bcMk4UK969uJLZUx4g" name="Mass transfer rate (intestine to mucosa blood cells)" description="Mass transfer rate (intestine to mucosa blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaBloodCells" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="SeDiYNMTjkiHEhobE46iNw" name="SmallIntestine_bc_UpperJejunum_bc" description="Neighborhood between Small Intestine/Blood Cells_ and Upper Jejunum/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="n6xwS0M17UWg01nLAvRLIQ" secondNeighbor="Ej30rRxCREi_lFbIacWhBg">
-            <Tags>
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="P6mN7RugdEyiYUiSikPkyA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="b8wYZNQf9kWrtRX0FnD2xQ" name="Mass transfer rate (intestine to mucosa blood cells)" description="Mass transfer rate (intestine to mucosa blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaBloodCells" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                </Children>
-              </Container>
-            </Children>
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-          <NeighborhoodBuilder id="Kq2wIa9rdkSK7rMqzWXz7g" name="SmallIntestine_pls_UpperJejunum_pls" description="Neighborhood between Small Intestine/Plasma_ and Upper Jejunum/Plasma" mode="Logical" containerType="Other" firstNeighbor="bKNuXngQSk-SQQe7D3MkAw" secondNeighbor="BfP4xKdBX0SaUMpMCDXvbg">
-            <Tags>
-              <Tag value="Neighborhood: Plasma / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="0bZz-gkFUkSUY2MWTEUSLA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="vz8UvpJMpEyUA-5RxaHZpg" name="Mass transfer rate (intestine to mucosa plasma)" description="Mass transfer rate (intestine to mucosa plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaPlasma" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                </Children>
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-            </Children>
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-          <NeighborhoodBuilder id="hiXefjVVwki9hAGOE1UYiA" name="SmallIntestine_bc_Duodenum_bc" description="Neighborhood between Small Intestine/Blood Cells_ and Duodenum/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="n6xwS0M17UWg01nLAvRLIQ" secondNeighbor="u4Ub16oEtECALrodgFre4w">
-            <Tags>
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="kI0Ucc84QEicmFMK-2bmmg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="VMgP0S-WRUSkp8K9QigfAw" name="Mass transfer rate (intestine to mucosa blood cells)" description="Mass transfer rate (intestine to mucosa blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaBloodCells" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="YzHP6Rj6XUWW5HzGbr21PQ" name="SmallIntestine_pls_Duodenum_pls" description="Neighborhood between Small Intestine/Plasma_ and Duodenum/Plasma" mode="Logical" containerType="Other" firstNeighbor="bKNuXngQSk-SQQe7D3MkAw" secondNeighbor="EkzIKZP1wU2_9u7Ncqke-Q">
-            <Tags>
-              <Tag value="Neighborhood: Plasma / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="4vB73xiW6U-cpIQQCDdDTA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="HQO4FDHR9U2rY6WfD_67NQ" name="Mass transfer rate (intestine to mucosa plasma)" description="Mass transfer rate (intestine to mucosa plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaPlasma" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="FFpVnZ4wIEOzerBdi93O7g" name="SmallIntestine_pls_UpperIleum_pls" description="Neighborhood between Small Intestine/Plasma_ and Upper Ileum/Plasma" mode="Logical" containerType="Other" firstNeighbor="bKNuXngQSk-SQQe7D3MkAw" secondNeighbor="agEz-d8UnU2AlENh6qiY5A">
-            <Tags>
-              <Tag value="Neighborhood: Plasma / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="Z5sc0uEpsUai5fSbEeSdCg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="y7OGJ4KxMUSL2EfrtEVpIQ" name="Mass transfer rate (intestine to mucosa plasma)" description="Mass transfer rate (intestine to mucosa plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaPlasma" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="O4XKroje0EGz5z2W4q-gDQ" name="LowerIleum_bc_PortalVein_bc" description="Neighborhood between Lower Ileum/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="ziNIenMYrkK_Eu94Cg5BFQ" secondNeighbor="ghMacG-81kSUPN5wkgPsnA">
-            <Tags>
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="xIVL0VAb4UKoDoWw4zKYBg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="FDE6gZEq4k-j5jsVz5JbLw" name="Mass transfer rate (mucosa to portal vein blood cells)" description="Mass transfer rate (mucosa to portal vein blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPveBloodCells" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="lg-cvn-NQUOomEaN9kAjKg" name="LowerIleum_pls_PortalVein_pls" description="Neighborhood between Lower Ileum/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="SheBaQRntUS7Uq436niclQ" secondNeighbor="-btXNr8mOEG_8ZCjsspLow">
-            <Tags>
-              <Tag value="Neighborhood: Plasma / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="Tz6cGbFQDEuV3L0ftX7OwQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="uOGiA8L5n0mobYSTTG5ZlQ" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPvePlasma" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="QS2Jm7ILeEicdYs6aj2dEw" name="SmallIntestine_bc_LowerIleum_bc" description="Neighborhood between Small Intestine/Blood Cells_ and Lower Ileum/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="n6xwS0M17UWg01nLAvRLIQ" secondNeighbor="ziNIenMYrkK_Eu94Cg5BFQ">
-            <Tags>
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="7ybB9cBdbUWvPGyCDEZaUw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="xzRjUOICckCbcz4BbXhmMw" name="Mass transfer rate (intestine to mucosa blood cells)" description="Mass transfer rate (intestine to mucosa blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaBloodCells" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="-MKpccwtv0ilmxXUAiaYMw" name="SmallIntestine_pls_LowerIleum_pls" description="Neighborhood between Small Intestine/Plasma_ and Lower Ileum/Plasma" mode="Logical" containerType="Other" firstNeighbor="bKNuXngQSk-SQQe7D3MkAw" secondNeighbor="SheBaQRntUS7Uq436niclQ">
-            <Tags>
-              <Tag value="Neighborhood: Plasma / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="nb9NnwOF2UOUkV-6PXTmnw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="M_O3uGOE-km2nxIcekyrZQ" name="Mass transfer rate (intestine to mucosa plasma)" description="Mass transfer rate (intestine to mucosa plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaPlasma" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="QWTnF4AbD0GR4YItyXNfTQ" name="Lumen_lil_LowerIleum_cell" description="Neighborhood between Lumen/Lower Ileum and Mucosa/Lower Ileum/Intracellular" mode="Logical" containerType="Other" firstNeighbor="vCPS2yMfPkKIhDcs0uJgFQ" secondNeighbor="an9mtKGGd0m69RC9jFTrLA">
-            <Tags>
-              <Tag value="Neighborhood: LowerIleum / Intracellular" />
-            </Tags>
-            <Children>
-              <Container id="FPaCsvTJBkuT8rXMGU3EOw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="Bucojw16iECS-HwP9HvoFg" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F2" visible="0" canBeVaried="0" />
-                  <Parameter id="eHiz-XHVlUK9XiPaUQwnHw" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F3" visible="0" canBeVaried="0" />
-                  <Parameter id="L5W0ZMzeo0GI0O51aWNK6w" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K1" visible="0" canBeVaried="0" />
-                  <Parameter id="u8dkg-pf5kakXjT09XFF7g" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K2" visible="0" canBeVaried="0" />
-                  <Parameter id="xybTZ6narU-T2KXC6r_xSQ" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K3" visible="0" canBeVaried="0" />
-                  <Parameter id="5Dm_pA5iPk65wEGCS2O-2w" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K4" visible="0" canBeVaried="0" />
-                  <Parameter id="s2co4Q-1SkCBdr3ifYtDTQ" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K5" visible="0" canBeVaried="0" />
-                  <Parameter id="DVXQk_NzhkKcuxU2XJq02w" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K6" visible="0" canBeVaried="0" />
-                  <Parameter id="3uxjSDP2xU2--9RxSplejA" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K7" visible="0" canBeVaried="0" />
-                  <Parameter id="uHcXrfR39kGthu-m-6FiTA" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K8" visible="0" canBeVaried="0" />
-                  <Parameter id="n1UBo4HVvkiasz227fM8GQ" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  <Parameter id="K9zziCu-F0m43y5gGVoKnA" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K7" visible="0" canBeVaried="0" />
-                  <Parameter id="W78srkq2nUSagrODSLzjqA" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  <Parameter id="s1nJcxALSEKE82gEU-Kcog" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_lum_cell_factor" visible="0" canBeVaried="0" />
-                  <Parameter id="65JdDwMY0kqxiyChH3DBcw" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F1" visible="0" canBeVaried="0" />
-                  <Parameter id="EJtFijp6x0GpGiCslbT93A" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_cell_lum_factor" visible="0" canBeVaried="0" />
-                  <Parameter id="Jsikb_K4ukOTQr2NypKovQ" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K8" visible="0" canBeVaried="0" />
-                  <Parameter id="loKnrk_m8Uaja8gnLj9z5A" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Lumen_PKSim.PARAM_K_cell_pls_LowerIleum" visible="0" canBeVaried="0" />
-                  <Parameter id="nqc8vM_ERkObocfG9aXdYw" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_LowerIleum" visible="0" canBeVaried="1" />
-                  <Parameter id="CSnCIS1yrkejcKV9lDhAYw" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F1" visible="0" canBeVaried="0" />
-                  <Parameter id="qlUJWnXjkUmMccKLVUShWw" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F2" visible="0" canBeVaried="0" />
-                  <Parameter id="K-RCFwjllUWfc_bIuO2LdA" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F3" visible="0" canBeVaried="0" />
-                  <Parameter id="2jXXT2n_2EG6fcbz6xHOxw" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K1" visible="0" canBeVaried="0" />
-                  <Parameter id="U9db6gbW-Uqqc7tr3zsDNA" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K2" visible="0" canBeVaried="0" />
-                  <Parameter id="hrsUTCYxUEK8xYQhJc1xjQ" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K3" visible="0" canBeVaried="0" />
-                  <Parameter id="9ENJAQOdbk6p23AxIfv8Sw" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K4" visible="0" canBeVaried="0" />
-                  <Parameter id="B03K2fZP0kq6XitcDLTVQg" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K5" visible="0" canBeVaried="0" />
-                  <Parameter id="MAfjMOJArkSuu3IkN3uPLw" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K6" visible="0" canBeVaried="0" />
-                  <Parameter id="_Vf5EPPFRUSt9KlZJQGXug" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_DrugAbsorption_trans" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="72bNBLX320emOf57IkxEQw" name="Lumen_lil_LowerIleum_pls" description="Neighborhood between Lumen/Lower Ileum and Mucosa/Lower Ileum/Plasma" mode="Logical" containerType="Other" firstNeighbor="vCPS2yMfPkKIhDcs0uJgFQ" secondNeighbor="SheBaQRntUS7Uq436niclQ">
-            <Tags>
-              <Tag value="Neighborhood: LowerIleum / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="iRiO1YL86ke4QlBQAom0nA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="Lj1jaY6-DEqJ4GW88moTAg" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_DrugAbsorption_para" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  <Parameter id="DluZXZ--9kmn5iF2_gNY_w" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  <Parameter id="0ZIn3S1Z80OiHSdKUcxsbQ" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="jgWzaqflz0qtLEKSlUDr9Q" name="SmallIntestine_int_SmallIntestine_cell" description="Neighborhood between Small Intestine/Interstitial and Small Intestine/Intracellular" mode="Logical" containerType="Other" firstNeighbor="QQEEFQ5iKUyN-6sUySP6Ig" secondNeighbor="eTOwNAWOSU2qVPwOLXoz1w">
-            <Tags>
-              <Tag value="Neighborhood: Interstitial / Intracellular" />
-              <Tag value="Small intestine  neighborhood" />
-            </Tags>
-            <Children>
-              <Container id="YqUZq6MAyUGoIn7XeFHrwg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="FSmQJGo6gE-qNX5KeddADQ" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                  <Parameter id="pqwKa4imtkqqHB7FN93PQQ" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                  <Parameter id="0f_XKZnmzEGWHIRPo80AqQ" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" visible="0" canBeVaried="1" displayUnit="l/min" />
-                  <Parameter id="HsknSPCi7UuxGJhWoB4CXA" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" visible="0" canBeVaried="1" displayUnit="l/min" />
-                  <Parameter id="guz8C3SKt0STDT86Aeu7QQ" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" visible="0" canBeVaried="1" />
-                  <Parameter id="sfXkwO2-e02nrYyjwUxCwA" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" visible="0" canBeVaried="1" />
-                  <Parameter id="KH9lb-8HrUqE9b460t48MA" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" visible="1" canBeVaried="1" />
-                  <Parameter id="WoE2nVWjM0CIEuB6DlK32w" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" visible="0" canBeVaried="1" />
-                </Children>
-              </Container>
-              <Parameter id="7OIGcBoUeEKGEEqYZSNW4A" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_sin" visible="1" canBeVaried="1" displayUnit="cm²" />
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-          <NeighborhoodBuilder id="CfU6WeJW-UCOtkedaaWGmw" name="SmallIntestine_pls_SmallIntestine_int" description="Neighborhood between Small Intestine/Plasma and Small Intestine/Interstitial" mode="Logical" containerType="Other" firstNeighbor="bKNuXngQSk-SQQe7D3MkAw" secondNeighbor="QQEEFQ5iKUyN-6sUySP6Ig">
-            <Tags>
-              <Tag value="Neighborhood: Plasma / Interstitial" />
-              <Tag value="Small intestine  neighborhood" />
-            </Tags>
-            <Children>
-              <Container id="Uxs1PVMVmEmC6FgOHncp4w" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="wnZyVTsp8EOaA2zX_OiqZg" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" visible="1" canBeVaried="1" />
-                  <Parameter id="imErF4NgxUu7TSLhf-yO0Q" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" visible="1" canBeVaried="1" value="10" displayUnit="cm/min" />
-                </Children>
-              </Container>
-              <Parameter id="I4uVVcCUp0ywlwslaavZOg" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int_sinlin" visible="1" canBeVaried="1" displayUnit="cm²" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="2De66y5MfkmZ1dzFPNyFoA" name="SmallIntestine_pls_SmallIntestine_bc" description="Neighborhood between Small Intestine/Plasma and Small Intestine/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="bKNuXngQSk-SQQe7D3MkAw" secondNeighbor="n6xwS0M17UWg01nLAvRLIQ">
-            <Tags>
-              <Tag value="Neighborhood: Plasma / BloodCells" />
-              <Tag value="Small intestine  neighborhood" />
-            </Tags>
-            <Children>
-              <Container id="viBINDHBWU-jSW-j8uqjnA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              <Parameter id="jSPK9ilsgkKZHpM4mLUwqg" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls_sinlin" visible="1" canBeVaried="1" displayUnit="cm²" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="sQJDWHoXAUSL9jbFLyswhA" name="SmallIntestine_pls_PortalVein_pls" description="Neighborhood between Small Intestine/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="bKNuXngQSk-SQQe7D3MkAw" secondNeighbor="-btXNr8mOEG_8ZCjsspLow">
-            <Tags>
-              <Tag value="Neighborhood: Plasma / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="zyJ9m3hBHU-vGlQFiTfB8g" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="ThIe-01caUeexuSHpSDPvQ" name="SmallIntestine_bc_PortalVein_bc" description="Neighborhood between Small Intestine/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="n6xwS0M17UWg01nLAvRLIQ" secondNeighbor="ghMacG-81kSUPN5wkgPsnA">
-            <Tags>
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="1siPrNONk0m287lKHxNQkg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="yObW1CONb0CBP837ALFL_Q" name="LargeIntestine_bc_PortalVein_bc" description="Neighborhood between Large Intestine/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="PHp1m9J9BUW9Wt4S_ZSJwQ" secondNeighbor="ghMacG-81kSUPN5wkgPsnA">
-            <Tags>
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="s-4SKES7AEux0NBdk5tysQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="zKNgga0vLEKOLHttadHekQ" name="LargeIntestine_bc_Rectum_bc" description="Neighborhood between Large Intestine/Blood Cells_ and Rectum/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="PHp1m9J9BUW9Wt4S_ZSJwQ" secondNeighbor="A3QoloDj00WaEjb1ONwwKw">
-            <Tags>
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="yWoQ_jNagECd3ezYdpsb4A" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="pdyWuNrUG0GRMOTnJbs_Iw" name="Mass transfer rate (intestine to mucosa blood cells)" description="Mass transfer rate (intestine to mucosa blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaBloodCells" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="x8b0o-sH0k2bTldDJBH6Aw" name="LargeIntestine_pls_Rectum_pls" description="Neighborhood between Large Intestine/Plasma_ and Rectum/Plasma" mode="Logical" containerType="Other" firstNeighbor="pX3ccCxXKEyKOoR4QI5kRg" secondNeighbor="CXXEeRMxZU-wWTrT4YIzVA">
-            <Tags>
-              <Tag value="Neighborhood: Plasma / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="qbGPo_pAZkybx6gMt-s7Pg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="iRFmyN7tGkarZD4jq36dNA" name="Mass transfer rate (intestine to mucosa plasma)" description="Mass transfer rate (intestine to mucosa plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaPlasma" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="OXjxFxxVG0qCQEC2jrKvwg" name="LargeIntestine_bc_ColonSigmoid_bc" description="Neighborhood between Large Intestine/Blood Cells_ and Colon Sigmoid/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="PHp1m9J9BUW9Wt4S_ZSJwQ" secondNeighbor="LQuH1MHvJ0af2kvb_nXBJQ">
-            <Tags>
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="_2uvc9eE9katB1GeJJr3Kw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="qq4xDt-n3kmDEo67M5W-_Q" name="Mass transfer rate (intestine to mucosa blood cells)" description="Mass transfer rate (intestine to mucosa blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaBloodCells" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="ATim0hXz3k6PbKFCMmi3-w" name="LargeIntestine_pls_ColonSigmoid_pls" description="Neighborhood between Large Intestine/Plasma_ and Colon Sigmoid/Plasma" mode="Logical" containerType="Other" firstNeighbor="pX3ccCxXKEyKOoR4QI5kRg" secondNeighbor="pJmj_UrpO0ioIgKx0SwyWg">
-            <Tags>
-              <Tag value="Neighborhood: Plasma / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="64fFrTc8zUiZHZgM3JHmSA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="R8l5iyDLcU61ZRGPU1AhAA" name="Mass transfer rate (intestine to mucosa plasma)" description="Mass transfer rate (intestine to mucosa plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaPlasma" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                </Children>
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-            <Tags>
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="BfjGKXoMlkiXZPaw0rG3QQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="J1jdmFi44E6dSbNodsDplw" name="Mass transfer rate (intestine to mucosa blood cells)" description="Mass transfer rate (intestine to mucosa blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaBloodCells" visible="0" canBeVaried="0" displayUnit="µmol/min" />
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-            <Tags>
-              <Tag value="Neighborhood: Plasma / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="i2dleMZfwUmqD5OVIVhdeg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="biDkhm4DU02FWyYIClf-HQ" name="Mass transfer rate (intestine to mucosa plasma)" description="Mass transfer rate (intestine to mucosa plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaPlasma" visible="0" canBeVaried="0" displayUnit="µmol/min" />
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-            <Tags>
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
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-            <Children>
-              <Container id="ZQG4Ss0qJkGFTt85-2eE1g" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="AwCPHOsIlkyFQVpJ7aeMKw" name="Mass transfer rate (intestine to mucosa blood cells)" description="Mass transfer rate (intestine to mucosa blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaBloodCells" visible="0" canBeVaried="0" displayUnit="µmol/min" />
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-            <Tags>
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
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-            <Children>
-              <Container id="pzZ3W1SglUSRg8jPyJAO-A" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="DK2WV4s_sUmzie9d5aL50A" name="Mass transfer rate (intestine to mucosa blood cells)" description="Mass transfer rate (intestine to mucosa blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaBloodCells" visible="0" canBeVaried="0" displayUnit="µmol/min" />
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-            <Tags>
-              <Tag value="Neighborhood: Plasma / Plasma" />
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-            <Children>
-              <Container id="CvK6bujqjkmqc4hGFt5VmA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="8JYRlu2NO0y3yFEpFrNmDA" name="Mass transfer rate (intestine to mucosa plasma)" description="Mass transfer rate (intestine to mucosa plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaPlasma" visible="0" canBeVaried="0" displayUnit="µmol/min" />
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-            <Tags>
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
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-            <Children>
-              <Container id="DQqtTNS2bkS6KzBE-D_yYw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="DGVBNfZM5kmVhNUZWnRvww" name="Mass transfer rate (intestine to mucosa blood cells)" description="Mass transfer rate (intestine to mucosa blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaBloodCells" visible="0" canBeVaried="0" displayUnit="µmol/min" />
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-            <Tags>
-              <Tag value="Neighborhood: Plasma / Plasma" />
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-            <Children>
-              <Container id="DvBKceVJJkKEoySfSXY2Rg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="U8heV4daOkuIcnU_S3bHxQ" name="Mass transfer rate (intestine to mucosa plasma)" description="Mass transfer rate (intestine to mucosa plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaPlasma" visible="0" canBeVaried="0" displayUnit="µmol/min" />
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-            <Tags>
-              <Tag value="Large intestine  neighborhood" />
-              <Tag value="Neighborhood: Plasma / BloodCells" />
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-            <Children>
-              <Container id="VL-Htk6hikyQxIb9P1Ejwg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              <Parameter id="vCc3RLhJ0E29GYS9QhLa1w" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls_sinlin" visible="1" canBeVaried="1" displayUnit="cm²" />
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-              <Tag value="Large intestine  neighborhood" />
-              <Tag value="Neighborhood: Interstitial / Intracellular" />
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-            <Children>
-              <Container id="FwCNptpuY0i1VHxdcQ72jQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="jO1kTcakzE-hooBCgQS7eA" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                  <Parameter id="FNHBNnlEP0GN1_LUfFqP1A" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                  <Parameter id="sHjKS_rB0ECqJy-hbrcUmw" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" visible="0" canBeVaried="1" displayUnit="l/min" />
-                  <Parameter id="3UUT_hyZ7Eim9rB3aK1U6Q" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" visible="0" canBeVaried="1" displayUnit="l/min" />
-                  <Parameter id="lcK_tIxdu0KdGrWzwe5RbA" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" visible="0" canBeVaried="1" />
-                  <Parameter id="yKqTX3JTZU2SrG23zZXStA" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" visible="0" canBeVaried="1" />
-                  <Parameter id="zfaHqNdfY0uKSCmAUSiiTw" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" visible="1" canBeVaried="1" />
-                  <Parameter id="-JH3_iMWeEeEpj0TgFIbFg" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" visible="0" canBeVaried="1" />
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-            <Tags>
-              <Tag value="Large intestine  neighborhood" />
-              <Tag value="Neighborhood: Plasma / Interstitial" />
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-            <Children>
-              <Container id="-0lyOGXHlki1S9AKFZefoQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="svzRSjRcKEi8H1Kr2MZ3hg" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" visible="1" canBeVaried="1" value="10" displayUnit="cm/min" />
-                  <Parameter id="ruuDiia79kGLIZCXPvUqow" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" visible="1" canBeVaried="1" />
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-              <Parameter id="2bLzN_54dkGTxfQDik3ePw" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int_sinlin" visible="1" canBeVaried="1" displayUnit="cm²" />
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-              <Container id="GC1uRazve0WcCO0958jrQg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="vUYBSFKzjUKfFIr3s0vsDw" name="Mass transfer rate (intestine to mucosa plasma)" description="Mass transfer rate (intestine to mucosa plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaPlasma" visible="0" canBeVaried="0" displayUnit="µmol/min" />
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-              <Container id="3R4cgESkmkGu2F94WA7s_A" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
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-            <Tags>
-              <Tag value="Neighborhood: Plasma / BloodCells" />
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-              <Container id="Zodh0ospGkyhAk_N_glr2Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              <Parameter id="89K3GDhUMUysuVWtX2G3CA" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" visible="1" canBeVaried="1" displayUnit="cm²" />
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-            <Tags>
-              <Tag value="Neighborhood: Plasma / Plasma" />
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-            <Children>
-              <Container id="uNVeNOpFXU-D7GBamKVRkw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
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-            <Children>
-              <Container id="h8gIyQc9jE-fIpZuFGpmkA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="W_5VDBnJ3UerLhWlnc_Y4Q" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" visible="0" canBeVaried="1" displayUnit="l/min" />
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-                  <Parameter id="3Q860lbw4UCVC_9ebWyR-w" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" visible="0" canBeVaried="1" />
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-            <Tags>
-              <Tag value="Neighborhood: Plasma / Interstitial" />
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-            <Children>
-              <Container id="VY3JlGvBvEa8lnyjdgZegw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="mthxw-EUOEGx9_JH-YuVlQ" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" visible="1" canBeVaried="1" value="10" displayUnit="cm/min" />
-                  <Parameter id="dYRvncJEtE6v4aW5uasgQg" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" visible="1" canBeVaried="1" />
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-              </Container>
-              <Parameter id="QaU_ktJR5k21FYDGQ_1U3g" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" visible="1" canBeVaried="1" displayUnit="cm²" />
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-              <Tag value="Neighborhood: Gallbladder / Duodenum" />
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-            <Children>
-              <Container id="feAGzaXR_ku91JCg_0_cRg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
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-            <Tags>
-              <Tag value="Neighborhood: Intracellular / Duodenum" />
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-            <Tags>
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-            <Tags>
-              <Tag value="Neighborhood: Plasma / BloodCells" />
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-              <Parameter id="fx1v1fm4ZE-vCf-ozbPucQ" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" visible="1" canBeVaried="1" displayUnit="cm²" />
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-              <Parameter id="MvyJy6taQUOyFQUWc6PRbw" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_lng" visible="1" canBeVaried="1" displayUnit="cm²" />
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-            <Children>
-              <Container id="UlShHMmY_U-xm4AxpXrgTA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="6q1w738rlUecd_cRpK8tSg" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" visible="0" canBeVaried="1" />
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-                  <Parameter id="vF4Ry8j5OkCpzRjPH49qJA" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                  <Parameter id="ACC96ZnV2kSJuEQpBZvkdA" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" visible="0" canBeVaried="1" displayUnit="l/min" />
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-                  <Parameter id="Ix25Q71WAk-Kg1ycS0XyUw" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" visible="1" canBeVaried="1" />
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-            <Tags>
-              <Tag value="Neighborhood: Plasma / BloodCells" />
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-              <Parameter id="y9EDW0BPsUq9YJ2ijXS37A" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" visible="1" canBeVaried="1" displayUnit="cm²" />
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-              <Container id="yF6zo973Y0CswmoBOhOhjQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
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-              <Tag value="Neighborhood: Interstitial / Intracellular" />
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-              <Container id="3faObynvWEy770K6kJwJfg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
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-                  <Parameter id="hLjzOjzOpUW-PRX0VYz0dw" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" visible="1" canBeVaried="1" />
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-              <Tag value="Neighborhood: BloodCells / BloodCells" />
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-              <Container id="Nsfi_iqkNEaCXqusNW-vbQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
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-            <Children>
-              <Container id="rkyrUuy47Eq7nqP30hh2gQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="jxoR--yBmU6K3YZ5FUSo9Q" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F1" visible="0" canBeVaried="0" />
-                  <Parameter id="7BHORjaAOUCCv7ZIwXzFIw" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_DrugAbsorption_trans" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  <Parameter id="M_FoKxzPn0GDsS0BJn13kA" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_cell_lum_factor" visible="0" canBeVaried="0" />
-                  <Parameter id="t3sNvrMjgUyjaybIry-S0g" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_lum_cell_factor" visible="0" canBeVaried="0" />
-                  <Parameter id="Dtw4UyMOvE273d1OJSokOg" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Lumen_PKSim.PARAM_K_cell_pls_Rectum" visible="0" canBeVaried="0" />
-                  <Parameter id="O7qudR4apkKinIfcVcQabA" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F2" visible="0" canBeVaried="0" />
-                  <Parameter id="ubQEs4SiKEmx3TEP2yjYyg" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_Rectum" visible="0" canBeVaried="1" />
-                  <Parameter id="82w_gJQ5n0eA7Vlcc6RrKg" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K8" visible="0" canBeVaried="0" />
-                  <Parameter id="AIdunjvqn0ytRguzAFRrrw" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  <Parameter id="7ks35SEt6EakJcCFTqCX8w" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  <Parameter id="kgrXtl_Yv0OQSuoNq6Wrvg" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K5" visible="0" canBeVaried="0" />
-                  <Parameter id="IVtRWgrmiUu9EJk5P_kAVg" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F1" visible="0" canBeVaried="0" />
-                  <Parameter id="g3ShDJC5OEKZTFnt7rDuOQ" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F3" visible="0" canBeVaried="0" />
-                  <Parameter id="oJA0vCv-wUKA7pzbPsAmrA" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K1" visible="0" canBeVaried="0" />
-                  <Parameter id="NR_YbMd6akG_9jUpCih_-g" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K2" visible="0" canBeVaried="0" />
-                  <Parameter id="DASP8UxkU06qiHvdFgdjSw" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K3" visible="0" canBeVaried="0" />
-                  <Parameter id="gQnkWyohgUeHau0kIwMUjg" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K4" visible="0" canBeVaried="0" />
-                  <Parameter id="96UTn4sbv0q3siMsTDryOQ" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K5" visible="0" canBeVaried="0" />
-                  <Parameter id="S_0VOqmrYEG-GUeT921TCw" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K6" visible="0" canBeVaried="0" />
-                  <Parameter id="QQpr-ZjFSEiEjhpMmFf_kg" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K7" visible="0" canBeVaried="0" />
-                  <Parameter id="1af4Uh3nN0CTH7noBXZpVA" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K8" visible="0" canBeVaried="0" />
-                  <Parameter id="xE20xi1C8Uy20b2Jpse8xA" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K6" visible="0" canBeVaried="0" />
-                  <Parameter id="nFYGJ5b6WEq4ODuRhkDAxg" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F2" visible="0" canBeVaried="0" />
-                  <Parameter id="zJszE2J4zUi_r20_bE_RFA" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F3" visible="0" canBeVaried="0" />
-                  <Parameter id="gsYL-ZNEHkik6yNGZaPmew" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K1" visible="0" canBeVaried="0" />
-                  <Parameter id="thdo5aQf-Eq-JU9YN1cQhQ" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K2" visible="0" canBeVaried="0" />
-                  <Parameter id="36wPSBNnxkuq8G6VMlS3Ig" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K3" visible="0" canBeVaried="0" />
-                  <Parameter id="CY5Are94c062tZn7BDpfjg" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K4" visible="0" canBeVaried="0" />
-                  <Parameter id="H9nDxKm7tE2y1YFIKRpvbA" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K7" visible="0" canBeVaried="0" />
-                </Children>
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-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="TzK9t9mevk-t-6YYvpwGAA" name="Rectum_pls_PortalVein_pls" description="Neighborhood between Rectum/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="CXXEeRMxZU-wWTrT4YIzVA" secondNeighbor="-btXNr8mOEG_8ZCjsspLow">
-            <Tags>
-              <Tag value="Neighborhood: Plasma / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="r4m1eE4uj024hsDg2J1Beg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="3vkGdmqE8EmwyNDHOQNrUQ" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPvePlasma" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="8fDxHU5RZE6GG6NDbIKFvw" name="Rectum_bc_PortalVein_bc" description="Neighborhood between Rectum/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="A3QoloDj00WaEjb1ONwwKw" secondNeighbor="ghMacG-81kSUPN5wkgPsnA">
-            <Tags>
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="tRQGmYmHkU2fH9YtedJV0A" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="_vW73uYhTESvg_RKdwlDwg" name="Mass transfer rate (mucosa to portal vein blood cells)" description="Mass transfer rate (mucosa to portal vein blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPveBloodCells" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="Qra6SzKOKEOPxXgSBXY8Uw" name="Lumen_rect_Rectum_pls" description="Neighborhood between Lumen/Rectum and Mucosa/Rectum/Plasma" mode="Logical" containerType="Other" firstNeighbor="tl7DiBQWEUGwcvPUXLf68w" secondNeighbor="CXXEeRMxZU-wWTrT4YIzVA">
-            <Tags>
-              <Tag value="Neighborhood: Rectum / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="xgM0EDf8Qki34_3WFxsJ3w" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="dytF7-rYgk6_iQQa4D80Vw" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_DrugAbsorption_para" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  <Parameter id="8Pvrkuaj9EKhPxogJVD0YQ" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  <Parameter id="WL3TwsnOR0qgI1NYIY-XsQ" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="4iiwGaLqfESUvVzw9xeG8A" name="PortalVein_pls_Liver_pls" description="Neighborhood between PortalVein/Plasma and Liver/Plasma" mode="Logical" containerType="Other" firstNeighbor="-btXNr8mOEG_8ZCjsspLow" secondNeighbor="kLQaFdxWjEyQKZou_zICsg">
-            <Tags>
-              <Tag value="Neighborhood: Plasma / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="6gTrjRu6LEaI19V-4-8cqw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="_mknA5vE4k2mRQPtiMhr4g" name="PortalVein_pls_PortalVein_bc" description="Neighborhood between PortalVein/Plasma and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="-btXNr8mOEG_8ZCjsspLow" secondNeighbor="ghMacG-81kSUPN5wkgPsnA">
-            <Tags>
-              <Tag value="Neighborhood: Plasma / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="uM_SmutDrku8rz7oN0WLTQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              <Parameter id="Etl_3ThYB0OH5VxuRom_aQ" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls_Blood_Organ" visible="1" canBeVaried="1" displayUnit="cm²" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="ynQ2F0aY8EecVhvTRFTrPQ" name="PortalVein_bc_Liver_bc" description="Neighborhood between PortalVein/Blood Cells and Liver/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="ghMacG-81kSUPN5wkgPsnA" secondNeighbor="yvxjl1guzkC2ZmC3cHheTA">
-            <Tags>
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="mPqsAqRMbUuk54eXdfqi6w" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="GY_sFr1M506DZDukD1BPaw" name="Skin_pls_VenousBlood_pls" description="Neighborhood between Skin/Plasma and Venous Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="WSZy9a4tjEazdIfolnG7tQ" secondNeighbor="AsKjCr0qtU6a-XJrIrGPTA">
-            <Tags>
-              <Tag value="Neighborhood: Plasma / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="x6tfWP2ZqUuUcRCJ0iOPGQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="ZsVOxIwoWk6D2cTjYZ7W9A" name="Skin_pls_Skin_bc" description="Neighborhood between Skin/Plasma and Skin/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="WSZy9a4tjEazdIfolnG7tQ" secondNeighbor="pPMIx8esx02hUpNFp0-EDQ">
-            <Tags>
-              <Tag value="Neighborhood: Plasma / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="kIs-S-ZULky_P0e6-sdloQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              <Parameter id="g43iMWCIxEmgz5k8byiUyw" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" visible="1" canBeVaried="1" displayUnit="cm²" />
-            </Children>
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-          <NeighborhoodBuilder id="nkNnQlyvDUCTvrz2Cwq32w" name="Skin_int_Skin_cell" description="Neighborhood between Skin/Interstitial and Skin/Intracellular" mode="Logical" containerType="Other" firstNeighbor="D2BE9ngGEUuvjzRqxqz8rQ" secondNeighbor="3we3dTuwDUm_9NjEJ_wiuA">
-            <Tags>
-              <Tag value="Neighborhood: Interstitial / Intracellular" />
-            </Tags>
-            <Children>
-              <Container id="1e5yq0y7zUKnPJcJwl4nsw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="V3I8pIwjPEK2Fg33fhG9Bg" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" visible="0" canBeVaried="1" />
-                  <Parameter id="oeJt16ebQE-wkygwX0gkMA" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" visible="1" canBeVaried="1" />
-                  <Parameter id="nBfv5uf0xUGFHnI7OJZHpg" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" visible="0" canBeVaried="1" />
-                  <Parameter id="hnRzxW2TmUuBmP0RilcXTA" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" visible="0" canBeVaried="1" displayUnit="l/min" />
-                  <Parameter id="YrUscu_V7kS2HT95K2z7WA" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" visible="0" canBeVaried="1" />
-                  <Parameter id="MeUxSjM__E6isRHaw2Rjhw" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" visible="0" canBeVaried="1" displayUnit="l/min" />
-                  <Parameter id="uhUxR3Eegkm9yBLHZ0ytmw" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                  <Parameter id="QYjibZ9U2Uu8ZeqmTN-JUQ" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                </Children>
-              </Container>
-              <Parameter id="NP4orrfYRUCa3UuUXqjP0Q" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_skn" visible="1" canBeVaried="1" displayUnit="cm²" />
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-          <NeighborhoodBuilder id="Tc3vPgdWY0Gp3ZxTtJk62g" name="Skin_pls_Skin_int" description="Neighborhood between Skin/Plasma and Skin/Interstitial" mode="Logical" containerType="Other" firstNeighbor="WSZy9a4tjEazdIfolnG7tQ" secondNeighbor="D2BE9ngGEUuvjzRqxqz8rQ">
-            <Tags>
-              <Tag value="Neighborhood: Plasma / Interstitial" />
-            </Tags>
-            <Children>
-              <Container id="XZESDiqw_Uif0PTMjieF5Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="bwtpVD8e2062DFtOPx-N9A" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" visible="1" canBeVaried="1" value="10" displayUnit="cm/min" />
-                  <Parameter id="1l_nbxQmPUaVKf0TUO_sbA" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" visible="1" canBeVaried="1" />
-                </Children>
-              </Container>
-              <Parameter id="OlCO6vh1lUyy_Rk122rRhA" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" visible="1" canBeVaried="1" displayUnit="cm²" />
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-            <Tags>
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
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-            <Children>
-              <Container id="dGlwGAvvLU6YTj6Jgl8VXQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
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-            <Tags>
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-            <Tags>
-              <Tag value="Neighborhood: Interstitial / Intracellular" />
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-            <Children>
-              <Container id="jeKovEYk9EuesnLFEVEqqA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="IJflFEVH6EausyUrX4Hv1g" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" visible="0" canBeVaried="1" />
-                  <Parameter id="4BlRMy4Ij0-nOc5yESy9tQ" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                  <Parameter id="_ElKZRkPMUuSRNgj93z93A" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                  <Parameter id="0fSi6Nfh50eodeuTA1QteQ" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" visible="0" canBeVaried="1" displayUnit="l/min" />
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-                  <Parameter id="cgFRlcO5R0q6AFIB1MrswQ" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" visible="1" canBeVaried="1" />
-                  <Parameter id="Ik9vGupnt0CfK3fjxXRH3A" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" visible="0" canBeVaried="1" />
-                  <Parameter id="SMaiHHI-_UiAJZbtCvjBOQ" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" visible="0" canBeVaried="1" displayUnit="l/min" />
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-              <Parameter id="1EZA4I2RZkKHFP_QBUgzUA" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_spl" visible="1" canBeVaried="1" displayUnit="cm²" />
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-            <Tags>
-              <Tag value="Neighborhood: Plasma / Interstitial" />
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-            <Children>
-              <Container id="7EnwSifCt0KMWsxjRRQgzA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="5rnNbsBzLE2_yi7hS6mTZw" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" visible="1" canBeVaried="1" value="10" displayUnit="cm/min" />
-                  <Parameter id="XJUK_XQBTEm_i2qoUyotoQ" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" visible="1" canBeVaried="1" />
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-              <Parameter id="JXIBi55paUSl_CQLwMaqHA" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" visible="1" canBeVaried="1" displayUnit="cm²" />
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-            <Tags>
-              <Tag value="Neighborhood: Plasma / BloodCells" />
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-            <Children>
-              <Container id="IZgQeNEb30GrwQxva9fCSg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              <Parameter id="8MZRRiVDEk2RA-0q6gDTGw" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" visible="1" canBeVaried="1" displayUnit="cm²" />
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-              <Tag value="Neighborhood: BloodCells / BloodCells" />
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-              <Tag value="Neighborhood: SalivaGland / Saliva" />
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-              <Container id="0uiSMzMk0EiMGrIuzsOcOQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="D2WMZWFLtkWt74Z-kQw4OA" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionSaliva_PKSim.PARAM_K_cell_pls_slv" visible="1" canBeVaried="1" />
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-            <Tags>
-              <Tag value="Neighborhood: Plasma / BloodCells" />
-              <Tag value="Small intestine  neighborhood" />
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-            <Children>
-              <Container id="6-a2sl5Zekyw_KQrpIk4KA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              <Parameter id="wb0QXaDCjkCdp4WVFEEgAA" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" visible="1" canBeVaried="1" displayUnit="cm²" />
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-            <Tags>
-              <Tag value="Neighborhood: Plasma / Interstitial" />
-              <Tag value="Small intestine  neighborhood" />
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-            <Children>
-              <Container id="nydSKfchG0qEBXzojTKuUA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="d9DRKM3UTUS2U03XSHLZxw" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" visible="1" canBeVaried="1" value="10" displayUnit="cm/min" />
-                  <Parameter id="706VHqHqxkaVh0W3FFKseg" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" visible="1" canBeVaried="1" />
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-              <Parameter id="ruDLOprPTk6U0qruYImCiQ" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" visible="1" canBeVaried="1" displayUnit="cm²" />
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-            <Tags>
-              <Tag value="Neighborhood: Interstitial / Intracellular" />
-              <Tag value="Small intestine  neighborhood" />
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-            <Children>
-              <Container id="TERrKv5Nhkmrwr_R86rAEA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="EPhrZKiMA0WX0dR1vjYTXw" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_P_int_cell_Mucosa" visible="1" canBeVaried="1" displayUnit="cm/min" />
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-                  <Parameter id="br8HopUoWkSRZGuYK24UmQ" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" visible="0" canBeVaried="1" displayUnit="l/min" />
-                  <Parameter id="v9ojJ6-cf0yCBOjxR2WXtA" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" visible="0" canBeVaried="1" />
-                  <Parameter id="7MqKFEjy0E2-A_XI_LALUA" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" visible="1" canBeVaried="1" />
-                  <Parameter id="j3yGhp4Oh0yKYmTrkJ8BnA" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" visible="0" canBeVaried="1" />
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-              <Parameter id="0jaBI415qkSVAyr7FrEQxw" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mucosa_duo" visible="1" canBeVaried="1" displayUnit="cm²" />
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-            <Tags>
-              <Tag value="Neighborhood: Interstitial / Intracellular" />
-              <Tag value="Small intestine  neighborhood" />
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-            <Children>
-              <Container id="OLv07VaaoEGIXgl60K0pjg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="DnEwyt93EU27KFHBjRs37w" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" visible="0" canBeVaried="1" />
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-                  <Parameter id="5-zGGXFYYka-mQEzjJbg8g" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_P_cell_int_Mucosa" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                  <Parameter id="iifMRu2QNE6zyTIEDqk-EA" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" visible="0" canBeVaried="1" displayUnit="l/min" />
-                  <Parameter id="9wqCBKtGpkm9viAxMV3a8Q" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" visible="0" canBeVaried="1" displayUnit="l/min" />
-                  <Parameter id="ztGyFAhQC0KWYycSxvBJ5g" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" visible="0" canBeVaried="1" />
-                  <Parameter id="StbmHvRHvE2G7b-09HHLsw" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" visible="1" canBeVaried="1" />
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-              <Parameter id="1I96AODwVUC3igUGDd-Oeg" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mucosa_uje" visible="1" canBeVaried="1" displayUnit="cm²" />
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-            <Tags>
-              <Tag value="Neighborhood: Plasma / BloodCells" />
-              <Tag value="Small intestine  neighborhood" />
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-            <Children>
-              <Container id="RijqkFjhAUSKbXf2qpGHgA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              <Parameter id="P6kzAY-UtkyyJFB5Y-aw2Q" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" visible="1" canBeVaried="1" displayUnit="cm²" />
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-            <Tags>
-              <Tag value="Neighborhood: Plasma / Interstitial" />
-              <Tag value="Small intestine  neighborhood" />
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-            <Children>
-              <Container id="3COLchtClEqD_POKPUd5rA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="BKOQxOLqCU22D-3_dSmtkA" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" visible="1" canBeVaried="1" value="10" displayUnit="cm/min" />
-                  <Parameter id="tsXHAXV5yEeB4uVPH6E9MQ" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" visible="1" canBeVaried="1" />
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-              <Parameter id="eFYPkrM_ykG8bufGpdLE9w" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" visible="1" canBeVaried="1" displayUnit="cm²" />
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-            <Tags>
-              <Tag value="Neighborhood: Plasma / Interstitial" />
-              <Tag value="Small intestine  neighborhood" />
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-            <Children>
-              <Container id="W79-rH8OsUyIalC7u2EcFw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="vPB6D4kN-E2gsIXdk13d3w" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" visible="1" canBeVaried="1" value="10" displayUnit="cm/min" />
-                  <Parameter id="FJTEuo44TEypjvNH8KWmag" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" visible="1" canBeVaried="1" />
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-              </Container>
-              <Parameter id="eUE-DZ1uRkyorkZpf4K0lA" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" visible="1" canBeVaried="1" displayUnit="cm²" />
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-            <Tags>
-              <Tag value="Neighborhood: Plasma / BloodCells" />
-              <Tag value="Small intestine  neighborhood" />
-            </Tags>
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-            <Tags>
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-              <Container id="vFF0eL9piEKzyO5qhv36yw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
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-                  <Parameter id="xPH_RClQLkShh8ApbGit7w" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" visible="0" canBeVaried="1" />
-                  <Parameter id="yXIbwnLh7EKdUoSqTU2uLA" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" visible="0" canBeVaried="1" displayUnit="l/min" />
-                  <Parameter id="MQvchJ4j7kqLzQkYhkCOVg" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" visible="0" canBeVaried="1" displayUnit="l/min" />
-                  <Parameter id="G5XwP1OAdUyjaNLD8hEr_w" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_P_cell_int_Mucosa" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                  <Parameter id="uJl8Hk7x0EOJ57dlKKimNQ" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_P_int_cell_Mucosa" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                </Children>
-              </Container>
-              <Parameter id="oJwrCpIhSU2-oDEkR-7_jQ" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mucosa_colsigm" visible="1" canBeVaried="1" displayUnit="cm²" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="PKbi-t53zEi9ZRTBNgzQ_Q" name="Rectum_pls_Rectum_int" description="Neighborhood between Large Intestine/Mucosa/Rectum/Plasma and Large Intestine/Mucosa/Rectum/Interstitial" mode="Logical" containerType="Other" firstNeighbor="CXXEeRMxZU-wWTrT4YIzVA" secondNeighbor="Ske4CMSGVEmut7Tm9FygjQ">
-            <Tags>
-              <Tag value="Large intestine  neighborhood" />
-              <Tag value="Neighborhood: Plasma / Interstitial" />
-            </Tags>
-            <Children>
-              <Container id="CDT-Ut1b3kmjC-OFUFynuA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="B8WHpoG4RkarMc1MHFaYtA" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" visible="1" canBeVaried="1" value="10" displayUnit="cm/min" />
-                  <Parameter id="OLeXvYT-vk-UbEG1Y12MSg" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" visible="1" canBeVaried="1" />
-                </Children>
-              </Container>
-              <Parameter id="2R5TYizSwkiA4Xcvz26ulw" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" visible="1" canBeVaried="1" displayUnit="cm²" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="I9yPpkCBqUmc2ccJ5dzxcg" name="Rectum_pls_Rectum_bc" description="Neighborhood between Large Intestine/Mucosa/Rectum/Plasma and Large Intestine/Mucosa/Rectum/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="CXXEeRMxZU-wWTrT4YIzVA" secondNeighbor="A3QoloDj00WaEjb1ONwwKw">
-            <Tags>
-              <Tag value="Large intestine  neighborhood" />
-              <Tag value="Neighborhood: Plasma / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="Rr3JQck-C0u1y3eZOFWYug" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              <Parameter id="YNumbnwSH0m7yZHJRLvJoA" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" visible="1" canBeVaried="1" displayUnit="cm²" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="uTPgjnMZx0yxA1BB9vUDog" name="Rectum_int_Rectum_cell" description="Neighborhood between Large Intestine/Mucosa/Rectum/Interstitial and Large Intestine/Mucosa/Rectum/Intracellular" mode="Logical" containerType="Other" firstNeighbor="Ske4CMSGVEmut7Tm9FygjQ" secondNeighbor="Wg0MyzCwzU6ebHpo_fikEg">
-            <Tags>
-              <Tag value="Large intestine  neighborhood" />
-              <Tag value="Neighborhood: Interstitial / Intracellular" />
-            </Tags>
-            <Children>
-              <Container id="BGOOVFHpD0GF75DzwLqkFA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="MrZSTyctKEanDu_LobVFIQ" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" visible="0" canBeVaried="1" />
-                  <Parameter id="HFqV--oR9E-F3jjKfl4isg" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_P_int_cell_Mucosa" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                  <Parameter id="arREll1JzUyw0e0Ylo5PFA" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_P_cell_int_Mucosa" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                  <Parameter id="XZevZgJjjUu85I0V_rkEIQ" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" visible="0" canBeVaried="1" displayUnit="l/min" />
-                  <Parameter id="jOLQUrpV602-fhAzE6FW2Q" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" visible="0" canBeVaried="1" displayUnit="l/min" />
-                  <Parameter id="qzaXVPJWdkeP8qjZ24UEBw" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" visible="0" canBeVaried="1" />
-                  <Parameter id="1QgbIMLxUUSDvlIjkZpcjg" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" visible="0" canBeVaried="1" />
-                  <Parameter id="Tx2t_xKZSUKcVWCtiZ7UMQ" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" visible="1" canBeVaried="1" />
-                </Children>
-              </Container>
-              <Parameter id="Wu5LXTQDUUetJNxPMHuNlw" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mucosa_rect" visible="1" canBeVaried="1" displayUnit="cm²" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="rssMYGIlZkyYhkM0ae77LQ" name="Caecum_bc_PortalVein_bc" description="Neighborhood between Cecum/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="aBn4kASOREa7YsOFIEj5NA" secondNeighbor="ghMacG-81kSUPN5wkgPsnA">
-            <Tags>
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="FefvuN8ZKEeGLjvzxLOTPg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="kW3o0NEAsUKgWNKG-aSLHA" name="Mass transfer rate (mucosa to portal vein blood cells)" description="Mass transfer rate (mucosa to portal vein blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPveBloodCells" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="vWw-JPAXj0et1dTQ4teJtA" name="Lumen_cae_Caecum_cell" description="Neighborhood between Lumen/Cecum and Mucosa/Cecum/Intracellular" mode="Logical" containerType="Other" firstNeighbor="sk41NH_8KEi_nNbtDlGvFA" secondNeighbor="Joj-umseKkiu2xQHcZDCWA">
-            <Tags>
-              <Tag value="Neighborhood: Caecum / Intracellular" />
-            </Tags>
-            <Children>
-              <Container id="Xg0uOBjrA06BPLehrM2_Bw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="cWb_jtSdqU-z-kiWVZs3gg" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_lum_cell_factor" visible="0" canBeVaried="0" />
-                  <Parameter id="DIpoG7vYsEGJDESOc7eNZw" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_DrugAbsorption_trans" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  <Parameter id="LV3jW1Smuk64H70wmZODhw" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Lumen_PKSim.PARAM_K_cell_pls_Caecum" visible="0" canBeVaried="0" />
-                  <Parameter id="dYVT8V6TyUeQe1QIK9s1Jg" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_cell_lum_factor" visible="0" canBeVaried="0" />
-                  <Parameter id="8tgbD54Fw0SE5rgMrLT2tg" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F2" visible="0" canBeVaried="0" />
-                  <Parameter id="44bnmq2SFUul2WHXV95ryQ" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_Caecum" visible="0" canBeVaried="1" />
-                  <Parameter id="wKw0IY2YvUqKKqRqvyy7hQ" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F1" visible="0" canBeVaried="0" />
-                  <Parameter id="1Nd181hGiECvSzxoYlzvgg" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F2" visible="0" canBeVaried="0" />
-                  <Parameter id="u-A9SsD_CUegyYbyHJHfgg" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F3" visible="0" canBeVaried="0" />
-                  <Parameter id="8H-uiS831UmZu1njDfU2ng" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K1" visible="0" canBeVaried="0" />
-                  <Parameter id="6kvP0PD0qkSiilgUwvCK9g" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K2" visible="0" canBeVaried="0" />
-                  <Parameter id="4uedEQRCREehS9zYZEo1lw" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K3" visible="0" canBeVaried="0" />
-                  <Parameter id="Us6wtejmZUSFTBOucc518A" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K4" visible="0" canBeVaried="0" />
-                  <Parameter id="Pd2wsst5MEiaibelpFMmxg" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K5" visible="0" canBeVaried="0" />
-                  <Parameter id="6-dAUTy1A0W6yl-wqqc78g" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K6" visible="0" canBeVaried="0" />
-                  <Parameter id="O9963Q34u0m7nAZPsqT2pQ" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K7" visible="0" canBeVaried="0" />
-                  <Parameter id="wln6KZsKNEWr9JnbZwwTlQ" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F1" visible="0" canBeVaried="0" />
-                  <Parameter id="rkAnCPINEkGWcRtC7sEeYQ" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F3" visible="0" canBeVaried="0" />
-                  <Parameter id="TWW-flJo9k-BBtwGpJRyqQ" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K1" visible="0" canBeVaried="0" />
-                  <Parameter id="9dPtWAvlVU6VkMhlYx-pjA" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K2" visible="0" canBeVaried="0" />
-                  <Parameter id="gzXUhmBHIkqM2P6V_s0OFA" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K3" visible="0" canBeVaried="0" />
-                  <Parameter id="Jp4F676uxUCxIrHuHdFn8Q" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K4" visible="0" canBeVaried="0" />
-                  <Parameter id="SSMMQ63nDEGOj2tV6IeVbg" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K5" visible="0" canBeVaried="0" />
-                  <Parameter id="gZ3H7xz3fke4vdTIEc_ufQ" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K6" visible="0" canBeVaried="0" />
-                  <Parameter id="JXz7FTXJ4E2KHd3wyFFKvw" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K7" visible="0" canBeVaried="0" />
-                  <Parameter id="4XTpH7VAOk6TtHx1KnuDYg" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K8" visible="0" canBeVaried="0" />
-                  <Parameter id="knHMOTGcAEesGP-s_SXxNQ" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  <Parameter id="WNSC0YGw40OmB4rZ8I2NpA" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  <Parameter id="PpAHIquJO0WvIvqdeKfsiQ" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K8" visible="0" canBeVaried="0" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="z_Y9H_G210yYpgEx8T2wHw" name="Lumen_cae_Caecum_pls" description="Neighborhood between Lumen/Cecum and Mucosa/Cecum/Plasma" mode="Logical" containerType="Other" firstNeighbor="sk41NH_8KEi_nNbtDlGvFA" secondNeighbor="LGbzLR1sNEiVJUOKeIrgIw">
-            <Tags>
-              <Tag value="Neighborhood: Caecum / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="P5lKU4HaK0m4IWQgplfCbw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="v-TsGIyai0COhw3GUHIfaA" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_DrugAbsorption_para" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  <Parameter id="kyJXZQylb0C4F9_vKHUDpw" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  <Parameter id="x_Qkf6cl5k6AYungghO1VA" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="P26zhBA3R0agZNgsyNt_Kg" name="Caecum_pls_PortalVein_pls" description="Neighborhood between Cecum/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="LGbzLR1sNEiVJUOKeIrgIw" secondNeighbor="-btXNr8mOEG_8ZCjsspLow">
-            <Tags>
-              <Tag value="Neighborhood: Plasma / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="zgw9JvSQ5EypkncsS2N3xQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="0Lx7cOYWbES4cANC89Ln9w" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPvePlasma" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="prZYW8EBDU6q5tx0LAPxsw" name="Lumen_coltrans_ColonTransversum_pls" description="Neighborhood between Lumen/Colon Transversum and Mucosa/Colon Transversum/Plasma" mode="Logical" containerType="Other" firstNeighbor="EhWe8Xqa6EKqp-YjJgQUiw" secondNeighbor="E3rvws_AOU-R8ZjRsJ7YJQ">
-            <Tags>
-              <Tag value="Neighborhood: ColonTransversum / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="c6FdX8Nb9Emm15hJtmHuDw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="qZO5zgZVKkahCP-GWH_mXw" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" visible="0" canBeVaried="0" displayUnit="µmol/min" />
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-              <Container id="RY_SUpt4XEWdXJ9TI96Gfw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
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-            <Tags>
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-              <Container id="2G_4TTtegkmQR5flSnuvKw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
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-            <Tags>
-              <Tag value="Neighborhood: Plasma / Plasma" />
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-            <Children>
-              <Container id="X_stNndoGUWw3cZ4Qkbqjg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="GtSZNlN150uJOKQ9pukA9g" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPvePlasma" visible="0" canBeVaried="0" displayUnit="µmol/min" />
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-            <Tags>
-              <Tag value="Neighborhood: ColonSigmoid / Intracellular" />
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-            <Children>
-              <Container id="KQuA0FuYJESW-C0TGhepVQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="pAFwFZxSN0u_MxU78HiRwQ" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_DrugAbsorption_trans" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  <Parameter id="Rm8wSkklvEWToAd8Vc7o3A" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K1" visible="0" canBeVaried="0" />
-                  <Parameter id="2NM4rUKqIky_-10UgkQADA" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_cell_lum_factor" visible="0" canBeVaried="0" />
-                  <Parameter id="d7DfnvLYvEKWfc54osHaWA" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_lum_cell_factor" visible="0" canBeVaried="0" />
-                  <Parameter id="D-EJi9d92U6TSaHDXFGuQg" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Lumen_PKSim.PARAM_K_cell_pls_ColonSigmoid" visible="0" canBeVaried="0" />
-                  <Parameter id="0saHhQPQXUa-3rS0YjdTIA" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_ColonSigmoid" visible="0" canBeVaried="1" />
-                  <Parameter id="BYu0BJACQki0HjLmqx4zLQ" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F1" visible="0" canBeVaried="0" />
-                  <Parameter id="aWsb0RstzU6PdkG9tFc0dQ" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F2" visible="0" canBeVaried="0" />
-                  <Parameter id="vcP_-2gSzESgDCdByla8jQ" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K2" visible="0" canBeVaried="0" />
-                  <Parameter id="Ka-3cTtPf0yRzvNLX-kqQg" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F3" visible="0" canBeVaried="0" />
-                  <Parameter id="LU8Zo0M8QUa5ZHd3OVVUjw" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K8" visible="0" canBeVaried="0" />
-                  <Parameter id="SRzt0xhHzkaXni7GMgMZGg" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K1" visible="0" canBeVaried="0" />
-                  <Parameter id="XHgeuBmWWE-qxURuW2hY4Q" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K3" visible="0" canBeVaried="0" />
-                  <Parameter id="tjtZBRrlb0GMVwrc9j0Prw" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K4" visible="0" canBeVaried="0" />
-                  <Parameter id="jsG73x2CnEeSWqG-l99C3w" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K5" visible="0" canBeVaried="0" />
-                  <Parameter id="BsAYGR-65k-CAhzliLkMEA" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K6" visible="0" canBeVaried="0" />
-                  <Parameter id="H4M6UKWE60-Bf_m5MoJ-vQ" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K7" visible="0" canBeVaried="0" />
-                  <Parameter id="KyRsYVGkJ0S_xH-ke3lvKw" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K8" visible="0" canBeVaried="0" />
-                  <Parameter id="gVPdumvkNUKLzS5IBmvZ6w" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F1" visible="0" canBeVaried="0" />
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-                  <Parameter id="fQYHTNRcik2Y1V73coy2gg" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F3" visible="0" canBeVaried="0" />
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-                  <Parameter id="pIi4ssGQ_k-ATWmQxwy3vg" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K2" visible="0" canBeVaried="0" />
-                  <Parameter id="2-m-4X6wL0OqwUkDbB3wKg" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K3" visible="0" canBeVaried="0" />
-                  <Parameter id="vH1irCkuOkCVLiOd-hL0XA" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K4" visible="0" canBeVaried="0" />
-                  <Parameter id="BzRMWeM-q0uVPKt_j0xKDg" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K5" visible="0" canBeVaried="0" />
-                  <Parameter id="htNCCj0S6U6K3Igj4QpFvg" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K6" visible="0" canBeVaried="0" />
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-            <Tags>
-              <Tag value="Neighborhood: ColonSigmoid / Plasma" />
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-            <Children>
-              <Container id="pVxFsD_eHkGygvfjLlZIEQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
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-                  <Parameter id="v4kj6TKCfEuEaC7i7G38PQ" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_DrugAbsorption_para" visible="0" canBeVaried="0" displayUnit="µmol/min" />
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-            <Tags>
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
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-            <Children>
-              <Container id="CzQpeJJ47UCijVjTse2C-Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="7Zn0divsfU6QTdguFnVEBA" name="Mass transfer rate (mucosa to portal vein blood cells)" description="Mass transfer rate (mucosa to portal vein blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPveBloodCells" visible="0" canBeVaried="0" displayUnit="µmol/min" />
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-          <NeighborhoodBuilder id="PvGQkurFg0Gs6byeCR-QMA" name="ColonDescendens_pls_PortalVein_pls" description="Neighborhood between Colon Descendens/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="xjPErKtgLE2tSY7-piU_pw" secondNeighbor="-btXNr8mOEG_8ZCjsspLow">
-            <Tags>
-              <Tag value="Neighborhood: Plasma / Plasma" />
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-            <Children>
-              <Container id="byFlXNxU7UK6IoL8s-_i3g" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
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-          <NeighborhoodBuilder id="Uk6-4-vglkG7ZCZ2JOGNBg" name="ColonSigmoid_bc_PortalVein_bc" description="Neighborhood between Colon Sigmoid/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="LQuH1MHvJ0af2kvb_nXBJQ" secondNeighbor="ghMacG-81kSUPN5wkgPsnA">
-            <Tags>
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-                  <Parameter id="XsIZy6cYQkq4MB-djCmRJA" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K5" visible="0" canBeVaried="0" />
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-                  <Parameter id="tRkmOXNEd0icfjQYltZC0w" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K8" visible="0" canBeVaried="0" />
-                  <Parameter id="LqM1DFn6fU-gu-4ng-ghUQ" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F1" visible="0" canBeVaried="0" />
-                  <Parameter id="ChiHFNwB3Uy4d6SEBA3YAQ" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F2" visible="0" canBeVaried="0" />
-                  <Parameter id="y_EOiJcjIk-vYPbnSP69HQ" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F3" visible="0" canBeVaried="0" />
-                  <Parameter id="K7ChnYUN0E6hfCJh7ZDArA" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K1" visible="0" canBeVaried="0" />
-                  <Parameter id="0iLL4TIZEk2IMPD2-cuo9A" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K3" visible="0" canBeVaried="0" />
-                  <Parameter id="n6qkz29uj0-SKgBuS4-gYQ" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K5" visible="0" canBeVaried="0" />
-                  <Parameter id="H0cJDks-bkCbyevXabrNWQ" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K6" visible="0" canBeVaried="0" />
-                  <Parameter id="z-T0VGYlNkesNpD3LPx9qA" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K7" visible="0" canBeVaried="0" />
-                  <Parameter id="RdbnuJq7oU2P_YzwkWKhCw" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K8" visible="0" canBeVaried="0" />
-                  <Parameter id="gAsyjFGuE0qYJneIWY2EZA" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  <Parameter id="VPhQuZ-k3U-iT3vNdGmpCA" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  <Parameter id="su1Ka9PzA02AaQo132fnOw" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K2" visible="0" canBeVaried="0" />
-                  <Parameter id="JZsQjfjpVUWI-ZCiqrUfcg" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K4" visible="0" canBeVaried="0" />
-                  <Parameter id="2MHuI82d70SA_ShUE3iLTg" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K6" visible="0" canBeVaried="0" />
-                  <Parameter id="Xlc_tdjrokC4LGuruQg_Bg" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Lumen_PKSim.PARAM_K_cell_pls_ColonDescendens" visible="0" canBeVaried="0" />
-                  <Parameter id="ehppCDhe1E-Ps98MrK9Apw" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_DrugAbsorption_trans" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  <Parameter id="-9dIwLVIt0umZ32IMcb0qg" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_lum_cell_factor" visible="0" canBeVaried="0" />
-                  <Parameter id="j1ytyJhN-USCfFwK_XYwpQ" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_ColonDescendens" visible="0" canBeVaried="1" />
-                  <Parameter id="-PJlASldqEmelanDtCfHiw" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F1" visible="0" canBeVaried="0" />
-                  <Parameter id="YCYA06AT_EGM01cQ86GakA" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F2" visible="0" canBeVaried="0" />
-                  <Parameter id="Gpxs5Ddx-kOM-IlTQkiNTg" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F3" visible="0" canBeVaried="0" />
-                  <Parameter id="3W8Tv00tp0eVNdKBeyAPXA" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K1" visible="0" canBeVaried="0" />
-                  <Parameter id="745RkbklQE2bNW6BqZkKjQ" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K2" visible="0" canBeVaried="0" />
-                  <Parameter id="gfTG0wpTakGPLvGJNTPgdQ" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K3" visible="0" canBeVaried="0" />
-                  <Parameter id="3M41ToZszUKUAEygEEVBug" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_cell_lum_factor" visible="0" canBeVaried="0" />
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-          <NeighborhoodBuilder id="xz7Mw7mDbEyiIA-t0J9rFw" name="Lumen_coldesc_ColonDescendens_pls" description="Neighborhood between Lumen/Colon Descendens and Mucosa/Colon Descendens/Plasma" mode="Logical" containerType="Other" firstNeighbor="TQQ1m1iJG0CQmvlfvaPkuA" secondNeighbor="xjPErKtgLE2tSY7-piU_pw">
-            <Tags>
-              <Tag value="Neighborhood: ColonDescendens / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="hfjCaS4VM0WPk_hBi9p0zw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="z0ffpsZzHUi5zDIQ2vx3gQ" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_DrugAbsorption_para" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  <Parameter id="-zkpzoEx-UOwNf8Q2Yrtbw" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  <Parameter id="Qq33oMDPgEKuM8VCfSGEcw" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                </Children>
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-          <NeighborhoodBuilder id="ChdcZU3UHka_4CdOtyAFcw" name="ColonTransversum_bc_PortalVein_bc" description="Neighborhood between Colon Transversum/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="tHA3JFaL-U-G9uaHbdHBSg" secondNeighbor="ghMacG-81kSUPN5wkgPsnA">
-            <Tags>
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="syBQ3koY80qmN7JBdlCvKQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="0OEcTrlItUyGW5WC-Jan_Q" name="Mass transfer rate (mucosa to portal vein blood cells)" description="Mass transfer rate (mucosa to portal vein blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPveBloodCells" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                </Children>
-              </Container>
-            </Children>
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-          <NeighborhoodBuilder id="DMV2DP--3Em5I6GbcAcThw" name="ColonTransversum_pls_PortalVein_pls" description="Neighborhood between Colon Transversum/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="E3rvws_AOU-R8ZjRsJ7YJQ" secondNeighbor="-btXNr8mOEG_8ZCjsspLow">
-            <Tags>
-              <Tag value="Neighborhood: Plasma / Plasma" />
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-            <Children>
-              <Container id="WZkd5Yi_9kGY_PO_fVio_Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
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-                  <Parameter id="HnNzFenHYEqZldsvPFkKtQ" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPvePlasma" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                </Children>
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-            <Tags>
-              <Tag value="Neighborhood: ColonTransversum / Intracellular" />
-            </Tags>
-            <Children>
-              <Container id="_iAwGfdFLEagNeM2OddL7Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="Q1DgvAGpNUSP_biNdeQ6-Q" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F2" visible="0" canBeVaried="0" />
-                  <Parameter id="N4fCeYWqQ0ecU0DGXEBTVg" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_DrugAbsorption_trans" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  <Parameter id="OiwA5SIOPU-638683Qg74g" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_cell_lum_factor" visible="0" canBeVaried="0" />
-                  <Parameter id="jaiDdzLP_UOMIGBsF3NpEg" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_lum_cell_factor" visible="0" canBeVaried="0" />
-                  <Parameter id="ek4sdtQr5E-h9GVA45fUwA" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Lumen_PKSim.PARAM_K_cell_pls_ColonTransversum" visible="0" canBeVaried="0" />
-                  <Parameter id="ac7Xt6iuSEKvVwWGup3qjA" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K7" visible="0" canBeVaried="0" />
-                  <Parameter id="0FPsm5_MOEGoiGw0D2MuOw" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F1" visible="0" canBeVaried="0" />
-                  <Parameter id="tJcfFT7mmUKdjgKpEfQVhw" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F3" visible="0" canBeVaried="0" />
-                  <Parameter id="XOVuz5uALEKP3FxaJv9K0A" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K1" visible="0" canBeVaried="0" />
-                  <Parameter id="Sm417Fq0A0-XlpbUCBaq-g" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K2" visible="0" canBeVaried="0" />
-                  <Parameter id="ehU8MwtiNUaDOYGAfIT46A" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K3" visible="0" canBeVaried="0" />
-                  <Parameter id="WN-jzU8yEkytQdNz0iamlA" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K4" visible="0" canBeVaried="0" />
-                  <Parameter id="yyDBUbwmREGOLvbjfczEwg" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K5" visible="0" canBeVaried="0" />
-                  <Parameter id="mfE5HpDWDUe3Yv7kiU67ZQ" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_ColonTransversum" visible="0" canBeVaried="1" />
-                  <Parameter id="gmJ-y6U7yESC1kIY-HRywQ" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K8" visible="0" canBeVaried="0" />
-                  <Parameter id="FfdvOkCFCUC4VzfFmuxSeg" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K6" visible="0" canBeVaried="0" />
-                  <Parameter id="62YnxcJH7Eyc9Fz2uMs7dQ" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K7" visible="0" canBeVaried="0" />
-                  <Parameter id="Od9wbYpfJ0S9yk39cmbBeg" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F1" visible="0" canBeVaried="0" />
-                  <Parameter id="kLsHtNO1bU-_tTaTrRXx1Q" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F2" visible="0" canBeVaried="0" />
-                  <Parameter id="Pu-RZaunrkqo70cjjjF2DQ" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F3" visible="0" canBeVaried="0" />
-                  <Parameter id="jH3tOdVzFEaKv5PDom51Ow" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K1" visible="0" canBeVaried="0" />
-                  <Parameter id="-T6y0lG7YUe04lFSjxG3hg" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K2" visible="0" canBeVaried="0" />
-                  <Parameter id="znIPAjZelEKLII00WEIqwg" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K3" visible="0" canBeVaried="0" />
-                  <Parameter id="AHLZCETaekGV-JQQiklkmg" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K4" visible="0" canBeVaried="0" />
-                  <Parameter id="kmedmZxQbUOSf6DsyaLbPg" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K6" visible="0" canBeVaried="0" />
-                  <Parameter id="GodGOGbik0C_r_vHe8D0tw" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K8" visible="0" canBeVaried="0" />
-                  <Parameter id="ZAO2hntka0C36TBY10u85g" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  <Parameter id="NOBFj5U1x0O5MUyKRBCHLg" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  <Parameter id="8LGDaOz4nEWT73VCTyFmhQ" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K5" visible="0" canBeVaried="0" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="G1QCI5vQ6k2k58iWyRuQjg" name="Lumen_colasc_ColonAscendens_cell" description="Neighborhood between Lumen/Colon Ascendens and Mucosa/Colon Ascendens/Intracellular" mode="Logical" containerType="Other" firstNeighbor="xYyLHo4Vhk6D6RJrPpFicA" secondNeighbor="_1aapd_LZk-snh-NLRJiBg">
-            <Tags>
-              <Tag value="Neighborhood: ColonAscendens / Intracellular" />
-            </Tags>
-            <Children>
-              <Container id="QJUBJ4ZEZkOU5VVJeYK6Sw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="RET_bN-ydUitCfliIQsqHA" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F2" visible="0" canBeVaried="0" />
-                  <Parameter id="67PHhCPZhkSFFMP7WSM94g" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F1" visible="0" canBeVaried="0" />
-                  <Parameter id="TMmYotbuNk6RXNDXaznO1Q" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_DrugAbsorption_trans" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  <Parameter id="Emwct4MoOkGYYZOw3jK-Ug" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_cell_lum_factor" visible="0" canBeVaried="0" />
-                  <Parameter id="9GBcoMSjTUmO9jPWkns5uA" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_lum_cell_factor" visible="0" canBeVaried="0" />
-                  <Parameter id="be6LNm4RwE-SDOQHdNC8gw" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_ColonAscendens" visible="0" canBeVaried="1" />
-                  <Parameter id="Mi5AQsjmjkq9G2_hXlo0Fg" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F2" visible="0" canBeVaried="0" />
-                  <Parameter id="voCagoNCk0GXT5huI9myQg" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F3" visible="0" canBeVaried="0" />
-                  <Parameter id="QWTZoVx8oE2OG66uXKZtsQ" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K1" visible="0" canBeVaried="0" />
-                  <Parameter id="GjUaTFRFV0ybPJaXQkF4lA" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K2" visible="0" canBeVaried="0" />
-                  <Parameter id="3xaQsaLKFkCTRcMDVQrhLA" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K3" visible="0" canBeVaried="0" />
-                  <Parameter id="nV-jAlf9Q0eTWO34FKC8mg" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K4" visible="0" canBeVaried="0" />
-                  <Parameter id="FDNch5Zg-UCUjuJeTeVWNQ" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K5" visible="0" canBeVaried="0" />
-                  <Parameter id="4Dm8T0MSV0uvZf4FYjOthg" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K6" visible="0" canBeVaried="0" />
-                  <Parameter id="uByLt0Iy9EOF4jjX-8xmSg" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K7" visible="0" canBeVaried="0" />
-                  <Parameter id="InvLOPB5Z02_47_Kr85zEw" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K8" visible="0" canBeVaried="0" />
-                  <Parameter id="MdwImgYtVUuPnUW9n9s3pQ" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F1" visible="0" canBeVaried="0" />
-                  <Parameter id="0uQ6GexPDEapE3Kw8P-uUw" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Lumen_PKSim.PARAM_K_cell_pls_ColonAscendens" visible="0" canBeVaried="0" />
-                  <Parameter id="tdP3CH3QJUqJY5yBLFG1Ig" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F3" visible="0" canBeVaried="0" />
-                  <Parameter id="u6nORz3vjky0Y1QGY7dZAw" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  <Parameter id="YPXfpD4vwEKHL7TFo3S4fg" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K1" visible="0" canBeVaried="0" />
-                  <Parameter id="Qv5wSIkicEaxLPBOeUx2KA" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K2" visible="0" canBeVaried="0" />
-                  <Parameter id="f2V_98czFk2hAFD2pse-pg" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K3" visible="0" canBeVaried="0" />
-                  <Parameter id="7YXpJ7vgOE2KOT39fv9UnQ" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K4" visible="0" canBeVaried="0" />
-                  <Parameter id="Fr1D0dIgME6gyJlpwb3mMg" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K5" visible="0" canBeVaried="0" />
-                  <Parameter id="dkvdWb2nZk6jBUYbl-8UNA" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K6" visible="0" canBeVaried="0" />
-                  <Parameter id="VOty3Usq9U6sFXCbAul3Cw" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K7" visible="0" canBeVaried="0" />
-                  <Parameter id="QTZzLP4KTUmAvC0IX1HIeQ" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  <Parameter id="_jF5ErmA0EGS8n4WcTG4EA" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K8" visible="0" canBeVaried="0" />
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-            <Tags>
-              <Tag value="Neighborhood: ColonAscendens / Plasma" />
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-            <Children>
-              <Container id="3pTq9sr-TkGbx_aMRqsLMw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="9EoK_Or7q0e5Ay42y8DCYA" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_DrugAbsorption_para" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  <Parameter id="RKTJpp_HsUuNFE8hF6Nm0g" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  <Parameter id="a7HjHBIG4EWZsEUO0L5Zng" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" visible="0" canBeVaried="0" displayUnit="µmol/min" />
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-          <NeighborhoodBuilder id="7Vz45c0ne0SKBE6eowX_nA" name="ArterialBlood_pls_Kidney_pls" description="Neighborhood between Arterial Blood/Plasma and Kidney/Plasma" mode="Logical" containerType="Other" firstNeighbor="B0yJEO0-kUqHLgCh369ADQ" secondNeighbor="vNliK8ccZ0mhuF90e6m6Sw">
-            <Tags>
-              <Tag value="Neighborhood: Plasma / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="xnpBmIHtbEuN6oWeUisLyg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
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-          <NeighborhoodBuilder id="vCr_SkULYkWpf-8IEFalfw" name="ArterialBlood_pls_LargeIntestine_pls" description="Neighborhood between Arterial Blood/Plasma and Large Intestine/Plasma" mode="Logical" containerType="Other" firstNeighbor="B0yJEO0-kUqHLgCh369ADQ" secondNeighbor="pX3ccCxXKEyKOoR4QI5kRg">
-            <Tags>
-              <Tag value="Neighborhood: Plasma / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="4Wsktk3tz0GYGEdBigywAQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
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-          <NeighborhoodBuilder id="gfZSHeJSC0KlSGozv7JnlQ" name="ArterialBlood_pls_Liver_pls" description="Neighborhood between Arterial Blood/Plasma and Liver/Plasma" mode="Logical" containerType="Other" firstNeighbor="B0yJEO0-kUqHLgCh369ADQ" secondNeighbor="kLQaFdxWjEyQKZou_zICsg">
-            <Tags>
-              <Tag value="Neighborhood: Plasma / Plasma" />
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-            <Children>
-              <Container id="qXTbRz6UYk-9e7LIJjzdTg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
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-          <NeighborhoodBuilder id="0GRlinkOzEGk8rr0QS1vOA" name="ArterialBlood_pls_Muscle_pls" description="Neighborhood between Arterial Blood/Plasma and Muscle/Plasma" mode="Logical" containerType="Other" firstNeighbor="B0yJEO0-kUqHLgCh369ADQ" secondNeighbor="yw1lF6NGzUebqB1RzY5lcA">
-            <Tags>
-              <Tag value="Neighborhood: Plasma / Plasma" />
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-            <Children>
-              <Container id="SJcNRQeBgUmFr2xLtrtrQw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
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-          <NeighborhoodBuilder id="ph_fNSlow02z2qdU_Dt6Tg" name="ArterialBlood_pls_Pancreas_pls" description="Neighborhood between Arterial Blood/Plasma and Pancreas/Plasma" mode="Logical" containerType="Other" firstNeighbor="B0yJEO0-kUqHLgCh369ADQ" secondNeighbor="XpMoC77tqU2dbzFapP7yNA">
-            <Tags>
-              <Tag value="Neighborhood: Plasma / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="VipEed9mFU-O8a9tFVKFSw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
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-          <NeighborhoodBuilder id="JOvnyeSigE2VRtMO6GYUCA" name="ArterialBlood_pls_Skin_pls" description="Neighborhood between Arterial Blood/Plasma and Skin/Plasma" mode="Logical" containerType="Other" firstNeighbor="B0yJEO0-kUqHLgCh369ADQ" secondNeighbor="WSZy9a4tjEazdIfolnG7tQ">
-            <Tags>
-              <Tag value="Neighborhood: Plasma / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="9A1EseKczUmPyxuVawNDuQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
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-          <NeighborhoodBuilder id="LKv-o_FXskyvyO5Z_I8EQA" name="ArterialBlood_pls_SmallIntestine_pls" description="Neighborhood between Arterial Blood/Plasma and Small Intestine/Plasma" mode="Logical" containerType="Other" firstNeighbor="B0yJEO0-kUqHLgCh369ADQ" secondNeighbor="bKNuXngQSk-SQQe7D3MkAw">
-            <Tags>
-              <Tag value="Neighborhood: Plasma / Plasma" />
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-            <Children>
-              <Container id="zYQwh8c9FkiJpYutpHQ2QQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
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-          <NeighborhoodBuilder id="GBqShH_arEqcH1bzZ3UAzA" name="ArterialBlood_pls_Fat_pls" description="Neighborhood between Arterial Blood/Plasma and Fat/Plasma" mode="Logical" containerType="Other" firstNeighbor="B0yJEO0-kUqHLgCh369ADQ" secondNeighbor="T_1TMJYsE0yHE_9nhhc74Q">
-            <Tags>
-              <Tag value="Neighborhood: Plasma / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="7tjWuvWOd0aHq_WLal7oBA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
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-          <NeighborhoodBuilder id="PPnIesiaS0Wk_gF6pp5-4Q" name="ArterialBlood_pls_Stomach_pls" description="Neighborhood between Arterial Blood/Plasma and Stomach/Plasma" mode="Logical" containerType="Other" firstNeighbor="B0yJEO0-kUqHLgCh369ADQ" secondNeighbor="wcVwGWqUikGrxah1-6Vx6A">
-            <Tags>
-              <Tag value="Neighborhood: Plasma / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="zrZBnYgUp0mSSxuyEC6jyg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
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-          <NeighborhoodBuilder id="4sODV2xbg06J3Xu51XTxXg" name="ArterialBlood_pls_Spleen_pls" description="Neighborhood between Arterial Blood/Plasma and Spleen/Plasma" mode="Logical" containerType="Other" firstNeighbor="B0yJEO0-kUqHLgCh369ADQ" secondNeighbor="K3klVlojjUGDpUNjF0hcjQ">
-            <Tags>
-              <Tag value="Neighborhood: Plasma / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="FjzgJO1iMEaHyugFGYr0YQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="uKxZjEt3BEO5DhI882q-yQ" name="ArterialBlood_bc_LargeIntestine_bc" description="Neighborhood between Arterial Blood/Blood Cells and Large Intestine/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="BuQVS6yXyUaIq4-4XAWfSA" secondNeighbor="PHp1m9J9BUW9Wt4S_ZSJwQ">
-            <Tags>
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="9bqkalSyi0KoOuBI84KGVg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="WS2q4KXm0EKCEcqDyI-8OQ" name="ArterialBlood_bc_Bone_bc" description="Neighborhood between Arterial Blood/Blood Cells and Bone/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="BuQVS6yXyUaIq4-4XAWfSA" secondNeighbor="FJ8onNQ3S0m05n8qe_e3lQ">
-            <Tags>
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="ZHUNuArK3UKMNbpjgQjIyg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="DEU3gsE6JUmfleZ_E5locA" name="ArterialBlood_bc_Brain_bc" description="Neighborhood between Arterial Blood/Blood Cells and Brain/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="BuQVS6yXyUaIq4-4XAWfSA" secondNeighbor="-hzUSP0H0UKYFyzMVYcHLg">
-            <Tags>
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="vsIDm_ptH0GhAOixCYMcGg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="obEQCbYaTEW6c4v-Gk-s2g" name="ArterialBlood_bc_Fat_bc" description="Neighborhood between Arterial Blood/Blood Cells and Fat/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="BuQVS6yXyUaIq4-4XAWfSA" secondNeighbor="x2EBR2z3O02CQY3uNWAaxQ">
-            <Tags>
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="XL6z6pcIek-hsMzHSwxqLw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="bYrMrS3mYkSEKfSfKoN_Vg" name="ArterialBlood_bc_Gonads_bc" description="Neighborhood between Arterial Blood/Blood Cells and Gonads/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="BuQVS6yXyUaIq4-4XAWfSA" secondNeighbor="lJHKHjIq9ESo-oG4BuGNgQ">
-            <Tags>
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="HtL3aphACES6ML__BoCU1w" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="6ef_sjjTL0eCl2FYb_19rA" name="ArterialBlood_pls_Heart_pls" description="Neighborhood between Arterial Blood/Plasma and Heart/Plasma" mode="Logical" containerType="Other" firstNeighbor="B0yJEO0-kUqHLgCh369ADQ" secondNeighbor="8FF9S5dtNES_fI7J-tqAmQ">
-            <Tags>
-              <Tag value="Neighborhood: Plasma / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="dNoHY-dptk-8EoXyfP81sA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="5CPndlslDUOXgsvq2NL04w" name="ArterialBlood_bc_Kidney_bc" description="Neighborhood between Arterial Blood/Blood Cells and Kidney/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="BuQVS6yXyUaIq4-4XAWfSA" secondNeighbor="8zPkGeGmU0OEOAd4v6wLwA">
-            <Tags>
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="Oky-m-Y4q0Ks-Kx8XkoyJQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="H0s9pnu_AkGNDfp50uhWng" name="ArterialBlood_bc_Liver_bc" description="Neighborhood between Arterial Blood/Blood Cells and Liver/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="BuQVS6yXyUaIq4-4XAWfSA" secondNeighbor="yvxjl1guzkC2ZmC3cHheTA">
-            <Tags>
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="y2bvvdQJ306BFUhT5MfqSg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="ZTtL-PzZ0kyLtXFfxD_Nfw" name="ArterialBlood_bc_Muscle_bc" description="Neighborhood between Arterial Blood/Blood Cells and Muscle/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="BuQVS6yXyUaIq4-4XAWfSA" secondNeighbor="zqX6cO98Rk-cr016qGkvtQ">
-            <Tags>
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="Hd891GErf0K4b5R2kGQCSw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="P6zsje3aVkOY0no78WVnOg" name="ArterialBlood_bc_Pancreas_bc" description="Neighborhood between Arterial Blood/Blood Cells and Pancreas/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="BuQVS6yXyUaIq4-4XAWfSA" secondNeighbor="cE6Ep5Tc7ESxE43Touo5cw">
-            <Tags>
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="fks34B7Cf0unPM31PGMBkQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="OT_l27vP0UqZxz4Shuf9sg" name="ArterialBlood_bc_Skin_bc" description="Neighborhood between Arterial Blood/Blood Cells and Skin/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="BuQVS6yXyUaIq4-4XAWfSA" secondNeighbor="pPMIx8esx02hUpNFp0-EDQ">
-            <Tags>
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="ICXVefcJF0yy8YSyAP-UZA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="yAzYPz2YA0W04e-JTL744A" name="ArterialBlood_bc_SmallIntestine_bc" description="Neighborhood between Arterial Blood/Blood Cells and Small Intestine/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="BuQVS6yXyUaIq4-4XAWfSA" secondNeighbor="n6xwS0M17UWg01nLAvRLIQ">
-            <Tags>
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="pOUN9cZYBEi43i-7lDNWBA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="FbiQqU5stkiW-4-RMXoE2Q" name="ArterialBlood_bc_Spleen_bc" description="Neighborhood between Arterial Blood/Blood Cells and Spleen/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="BuQVS6yXyUaIq4-4XAWfSA" secondNeighbor="UpAw1d6XKEShunReyqujGw">
-            <Tags>
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="5o-gUHrOp0W51SFQUKgFNQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="2kMlxIgVOUiY3vodXiThYg" name="ArterialBlood_bc_Stomach_bc" description="Neighborhood between Arterial Blood/Blood Cells and Stomach/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="BuQVS6yXyUaIq4-4XAWfSA" secondNeighbor="ZsgRGsl2Ika6nIUVelD34g">
-            <Tags>
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="RKIMDJJ7bUSnh6bU4q7paQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="QdZrpSkPo0mqwqW6cfWXBg" name="ArterialBlood_pls_Bone_pls" description="Neighborhood between Arterial Blood/Plasma and Bone/Plasma" mode="Logical" containerType="Other" firstNeighbor="B0yJEO0-kUqHLgCh369ADQ" secondNeighbor="5qhBG-74sEmSAgcDLdsKOw">
-            <Tags>
-              <Tag value="Neighborhood: Plasma / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="8DN7nQSfGUiD5iF2RigEbg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="RmUhlxYcHUavmO4P3f4icA" name="ArterialBlood_bc_Heart_bc" description="Neighborhood between Arterial Blood/Blood Cells and Heart/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="BuQVS6yXyUaIq4-4XAWfSA" secondNeighbor="2ChqB3XlJECSWoT4xWUL4g">
-            <Tags>
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="BVN1zQClwky7MezZDJeEsA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="NNkXB6Btk0yOtzC0XndYNQ" name="ArterialBlood_pls_Gonads_pls" description="Neighborhood between Arterial Blood/Plasma and Gonads/Plasma" mode="Logical" containerType="Other" firstNeighbor="B0yJEO0-kUqHLgCh369ADQ" secondNeighbor="WeKcMw4iF0S7FmaFEOg7rA">
-            <Tags>
-              <Tag value="Neighborhood: Plasma / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="P_wqCR1ZTkOqHa25b9osAw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="RYdeMHtbM0a94Ht0ycMTbA" name="ArterialBlood_pls_Brain_pls" description="Neighborhood between Arterial Blood/Plasma and Brain/Plasma" mode="Logical" containerType="Other" firstNeighbor="B0yJEO0-kUqHLgCh369ADQ" secondNeighbor="DF7RMcQS5kelas00ZZs78w">
-            <Tags>
-              <Tag value="Neighborhood: Plasma / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="erpscbQ0kEG1wT2GUcDw8Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="ZxQIzfuwOkGF8G9mxFt1Ow" name="Duodenum_bc_PortalVein_bc" description="Neighborhood between Duodenum/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="u4Ub16oEtECALrodgFre4w" secondNeighbor="ghMacG-81kSUPN5wkgPsnA">
-            <Tags>
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="L9yEGNPLI0KAdiNbXEvsqA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="6fZw1VuNvE-FBYtS-rhwrg" name="Mass transfer rate (mucosa to portal vein blood cells)" description="Mass transfer rate (mucosa to portal vein blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPveBloodCells" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="X99BGpS85EOm7qXiqFMjPQ" name="Duodenum_pls_PortalVein_pls" description="Neighborhood between Duodenum/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="EkzIKZP1wU2_9u7Ncqke-Q" secondNeighbor="-btXNr8mOEG_8ZCjsspLow">
-            <Tags>
-              <Tag value="Neighborhood: Plasma / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="LA8L1Id1EUioBHCdPGU2iQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="TzHGs-34k0WhrWLs3r1jEg" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPvePlasma" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="mGAF7JPrQES5_3do9Zei-w" name="Lumen_duo_Duodenum_cell" description="Neighborhood between Lumen/Duodenum and Mucosa/Duodenum/Intracellular" mode="Logical" containerType="Other" firstNeighbor="B2SJL0T_506x1Wlk3TTamQ" secondNeighbor="V_ZJM8cPkEqPs_Ft62p6cg">
-            <Tags>
-              <Tag value="Neighborhood: Duodenum / Intracellular" />
-            </Tags>
-            <Children>
-              <Container id="PCF_DYz-Ekm2MK94IeZu5A" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="se4T5bUP70enItiL9OiWqQ" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K7" visible="0" canBeVaried="0" />
-                  <Parameter id="QZBZ5FFF5kepzB4EmDAw4A" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K5" visible="0" canBeVaried="0" />
-                  <Parameter id="Ux9rgrPhCEqUOLFGKttASA" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K6" visible="0" canBeVaried="0" />
-                  <Parameter id="H3uM6Z51Oka8F85cQbxY-g" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K7" visible="0" canBeVaried="0" />
-                  <Parameter id="TFMmB08A60CDMxF_E8dW7g" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K8" visible="0" canBeVaried="0" />
-                  <Parameter id="T682TmjLkkeBJEy_Nw-0zA" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F1" visible="0" canBeVaried="0" />
-                  <Parameter id="FVhOykippU65XmWfNU0G0A" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F2" visible="0" canBeVaried="0" />
-                  <Parameter id="FORyMvF8CkuqCsQQbTfoUA" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F3" visible="0" canBeVaried="0" />
-                  <Parameter id="SLtVAaQ87UaNRJnlYUshTw" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K1" visible="0" canBeVaried="0" />
-                  <Parameter id="PN3OuQwHPUiYMDFqjPacVw" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K2" visible="0" canBeVaried="0" />
-                  <Parameter id="9cBQYCJudUu2prAmEunoBg" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K3" visible="0" canBeVaried="0" />
-                  <Parameter id="G3Go02fgYEWuyOU42WlFOw" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K4" visible="0" canBeVaried="0" />
-                  <Parameter id="Jm8xifho106-X9dk2nsUEQ" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K6" visible="0" canBeVaried="0" />
-                  <Parameter id="aGGX4N4MzkOGgYMds6WZAA" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K2" visible="0" canBeVaried="0" />
-                  <Parameter id="R80tN6CQt0WWn7Q0U320Dw" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K8" visible="0" canBeVaried="0" />
-                  <Parameter id="LHne2iNWgE-7RXdXWQHrgQ" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  <Parameter id="w6ovlBtycUqSZZrvMOCBhQ" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  <Parameter id="FmnOlk8170SDXZVlahU9wQ" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K5" visible="0" canBeVaried="0" />
-                  <Parameter id="53xbzZLk-Eirvwx7PZMhNg" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K4" visible="0" canBeVaried="0" />
-                  <Parameter id="JiQT2ybEn0Kaf4axepnxvg" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K3" visible="0" canBeVaried="0" />
-                  <Parameter id="hmp6fhTqzkq98Gi8wqkddQ" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_DrugAbsorption_trans" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  <Parameter id="maLnrDkL602ZfYfioq5zvw" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_cell_lum_factor" visible="0" canBeVaried="0" />
-                  <Parameter id="8wGo5j3Rw0-JlTICgfZgaA" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_lum_cell_factor" visible="0" canBeVaried="0" />
-                  <Parameter id="3T-5CIO0nUCmTxaRoFvs_Q" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Lumen_PKSim.PARAM_K_cell_pls_Duodenum" visible="0" canBeVaried="0" />
-                  <Parameter id="ZuEP0zWRGEiRwnXvCLh9zg" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_Duodenum" visible="0" canBeVaried="1" />
-                  <Parameter id="b8WtOfn0KEazq1gyqDidNg" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F1" visible="0" canBeVaried="0" />
-                  <Parameter id="rMxGtxCZw0Sm3YaXe4Ws7g" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F2" visible="0" canBeVaried="0" />
-                  <Parameter id="JDa1HyJhTUqHX6boyVlh4A" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F3" visible="0" canBeVaried="0" />
-                  <Parameter id="rZ-X0x9QpUe_xqgUnN7Rqg" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K1" visible="0" canBeVaried="0" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="BN29-Ry1H0WdSKBZLcKPow" name="Lumen_duo_Duodenum_pls" description="Neighborhood between Lumen/Duodenum and Mucosa/Duodenum/Plasma" mode="Logical" containerType="Other" firstNeighbor="B2SJL0T_506x1Wlk3TTamQ" secondNeighbor="EkzIKZP1wU2_9u7Ncqke-Q">
-            <Tags>
-              <Tag value="Neighborhood: Duodenum / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="LzEyzYCcUEGJ6z9T7dQGaA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="Vgzbh5XXRkWTsnphbD0Diw" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="Lumen_PKSim.PARAM_DrugAbsorption_para" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  <Parameter id="GQl8VZynnEirDu24OMCz8w" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  <Parameter id="AM3Hs5AdAEu3vLbuBuwo_A" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="DynamicSumFormulas.PARAM_SumOfPassiveProcessRates" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="6AOrlhR8OkSmcDRzurDeHQ" name="ColonTransversum_cell__VenousBlood_pls" description="Neighborhood between LargeIntestine/Mucosa/ColonTransversum/Interstitial and Venous Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="OSCX1Pbj-0qKg7UUO5RmPA" secondNeighbor="AsKjCr0qtU6a-XJrIrGPTA">
-            <Tags>
-              <Tag value="Neighborhood: Interstitial / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="5ZidpamTukis0WvNDJncvw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="59Sh4plW60SIWjw4I_lE7A" name="ColonDescendens_cell__VenousBlood_pls" description="Neighborhood between LargeIntestine/Mucosa/ColonDescendens/Interstitial and Venous Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="UB8UfObHaEKIJ6imuRVB1g" secondNeighbor="AsKjCr0qtU6a-XJrIrGPTA">
-            <Tags>
-              <Tag value="Neighborhood: Interstitial / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="ktnNsSUiUEiEaUUDu5i-LQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="2GhARIfG0kaDzzRMystWvg" name="ColonSigmoid_cell__VenousBlood_pls" description="Neighborhood between LargeIntestine/Mucosa/ColonSigmoid/Interstitial and Venous Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="hmTQ2xRfwU-6I_WaFzZk6w" secondNeighbor="AsKjCr0qtU6a-XJrIrGPTA">
-            <Tags>
-              <Tag value="Neighborhood: Interstitial / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="Aj8uKP1L60mbo1dv1ETN2Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="wkUpproZe0S0jGJMllTOQw" name="Rectum_cell__VenousBlood_pls" description="Neighborhood between LargeIntestine/Mucosa/Rectum/Interstitial and Venous Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="Ske4CMSGVEmut7Tm9FygjQ" secondNeighbor="AsKjCr0qtU6a-XJrIrGPTA">
-            <Tags>
-              <Tag value="Neighborhood: Interstitial / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="Hd43sSZflUCdATyXJb9PDQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
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-            </Paths>
-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_hrt" name="PARAM_K_Water_INT_hrt" dim="Dimensionless" formula="K_water_int">
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-            </Paths>
-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_hrt" name="PARAM_K_Water_CELL_hrt" dim="Dimensionless" formula="K_water_cell">
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-            </Paths>
-          </Formula>
-          <Formula id="VascularEndoVolume.VOLUME_VascularEndo_kid" name="VOLUME_VascularEndo_kid" dim="Volume" formula="SA_pls_int*d_endo">
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-          <Formula id="Individual_PKSim.PARAM_Lymph_flow_rate_Kidney" name="PARAM_Lymph_flow_rate_Kidney" dim="Flow" formula="0.00000021*BW/0.02">
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-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_kid" name="PARAM_K_Water_CELL_kid" dim="Dimensionless" formula="K_water_cell">
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-          <Formula id="CompartmentsVolume_4Comp.VOLUME_LumenSegment" name="VOLUME_LumenSegment" dim="Volume" formula="PI*(r1*r1+r1*r2+r2*r2)/3*L">
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-          </Formula>
-          <Formula id="Lumen_PKSim.PARAM_pH_from_pH_fasted" name="PARAM_pH_from_pH_fasted" dim="Dimensionless" formula="pH_fasted">
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-          </Formula>
-          <Formula id="Lumen_PKSim.PARAM_Inflow_Stomach" name="PARAM_Inflow_Stomach" dim="Flow" formula="SteadyStateFillLevel*V/StomachInflowTime">
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-          <Formula id="Lumen_PKSim.PARAM_FillLevelFlagFlag" name="PARAM_FillLevelFlagFlag" dim="Dimensionless" formula="(FillLevel&lt;0.9?1:1/(1+exp((FillLevel-1)/0.01)))">
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-          </Formula>
-          <Formula id="Lumen_PKSim.PARAM_FillLevel" name="PARAM_FillLevel" dim="Dimensionless" formula="Liquid/V">
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-          </Formula>
-          <Formula id="Lumen_PKSim.PARAM_Area" name="PARAM_Area" dim="Area" formula="PI*(r1+r2)*L">
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-              <Path path="231" as="232" dim="161" />
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-          </Formula>
-          <Formula id="Lumen_PKSim.PARAM_InverseGastricEmptyingTime" name="PARAM_InverseGastricEmptyingTime" dim="Inversed time" formula="1/GET">
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-            </Paths>
-          </Formula>
-          <Formula id="Lumen_PKSim.PARAM_Liquid_StartValue" name="PARAM_Liquid_StartValue" dim="Volume" formula="V*SteadyStateFillLevel">
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-          </Formula>
-          <Formula id="Lumen_PKSim.LiquidRHS_sto" name="LiquidRHS_sto" dim="Flow" formula="OralApplicationsEnabled ? -LT_sto + Inflow*FillLevelFlag : 0">
-            <Paths>
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-              <Path path="252" as="253" dim="220" />
-              <Path path="254" as="255" dim="220" />
-              <Path path="256" as="257" />
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-          </Formula>
-          <Formula id="Lumen_PKSim.PARAM_LiquidTransferRate_sto" name="PARAM_LiquidTransferRate_sto" dim="Flow" formula="w*Liquid*FillLevelFlagNext">
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-              <Path path="246" as="247" dim="51" />
-              <Path path="260" as="261" />
-            </Paths>
-          </Formula>
-          <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" name="PARAM_pKa_pH_WS_lum_ForSol_K3" dim="Dimensionless" formula="F1*(1-F2)*F3">
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-              <Path path="266" as="267" />
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-          </Formula>
-          <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" name="PARAM_pKa_pH_WS_lum_ForSol_K2" dim="Dimensionless" formula="(1-F1)*F2*F3">
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-          <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" name="PARAM_pKa_pH_WS_lum_ForSol_K1" dim="Dimensionless" formula="F1*F2*F3">
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-          </Formula>
-          <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" name="PARAM_pKa_pH_WS_lum_ForSol_F3" dim="Dimensionless" formula="CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1">
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-          <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" name="PARAM_pKa_pH_WS_lum_ForSol_F2" dim="Dimensionless" formula="CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1">
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-          </Formula>
-          <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" name="PARAM_pKa_pH_WS_lum_ForSol_F1" dim="Dimensionless" formula="CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1">
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-              <Path path="280" as="281" />
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-          </Formula>
-          <Formula id="CompoundCommon.PARAM_OntogenyFactor_FromGlobal_GI" name="PARAM_OntogenyFactor_FromGlobal_GI" dim="Dimensionless" formula="f_onto">
-            <Paths>
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-            </Paths>
-          </Formula>
-          <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" name="PARAM_pKa_pH_WS_lum_ForSol_K5" dim="Dimensionless" formula="(1-F1)*(1-F2)*F3">
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-              <Path path="262" as="263" />
-              <Path path="264" as="265" />
-              <Path path="266" as="267" />
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-          </Formula>
-          <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" name="PARAM_pKa_pH_WS_lum_ForSol_K6" dim="Dimensionless" formula="(1-F1)*F2*(1-F3)">
-            <Paths>
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-              <Path path="264" as="265" />
-              <Path path="266" as="267" />
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-          </Formula>
-          <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" name="PARAM_pKa_pH_WS_lum_ForSol_K4" dim="Dimensionless" formula="F1*F2*(1-F3)">
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-              <Path path="262" as="263" />
-              <Path path="264" as="265" />
-              <Path path="266" as="267" />
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-          </Formula>
-          <Formula id="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" name="PARAM_Solubility_pKa_pH_Factor" dim="Dimensionless" formula="K1+K2/base^(CT0^2)+K3/base^(CT1^2)+K4/base^(CT2^2)+K5/base^max(CT0+CT1;-CT0-CT1)+K6/base^max(CT0+CT2;-CT0-CT2)+K7/base^max(CT1+CT2;-CT1-CT2)+K8/base^max(CT0+CT1+CT2;-CT0-CT1-CT2)">
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-          </Formula>
-          <Formula id="Lumen_PKSim.PARAM_IntestinalSolubility" name="PARAM_IntestinalSolubility" dim="Concentration (mass)" formula="Solubility * Solubility_pKa_REFpH_Factor / Solubility_pKa_pH_Factor">
-            <Paths>
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-              <Path path="308" as="309" />
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-          <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" name="PARAM_pKa_pH_WS_lum_ForSol_K7" dim="Dimensionless" formula="F1*(1-F2)*(1-F3)">
-            <Paths>
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-              <Path path="264" as="265" />
-              <Path path="266" as="267" />
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-          </Formula>
-          <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" name="PARAM_pKa_pH_WS_lum_ForSol_K8" dim="Dimensionless" formula="(1-F1)*(1-F2)*(1-F3)">
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-              <Path path="262" as="263" />
-              <Path path="264" as="265" />
-              <Path path="266" as="267" />
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-          </Formula>
-          <Formula id="Lumen_Geometry.PARAM_Lumen_Geometry_R1" name="PARAM_Lumen_Geometry_R1" dim="Length" formula="r1_p0 + Height*r1_p1">
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-              <Path path="311" as="312" dim="161" />
-              <Path path="313" as="314" />
-            </Paths>
-          </Formula>
-          <Formula id="Lumen_PKSim.PARAM_Outflow_Duodenum" name="PARAM_Outflow_Duodenum" dim="Inversed time" formula="(k_p*alpha_p*V_p+inflow-k*alpha*V)/(alpha*V)">
-            <Paths>
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-              <Path path="258" as="316" dim="46" />
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-          </Formula>
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-              <Path path="326" as="327" />
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-          </Formula>
-          <Formula id="Lumen_PKSim.PARAM_InverseSITT_Factor_Duodenum" name="PARAM_InverseSITT_Factor_Duodenum" dim="Inversed time" formula="LuminalVelocity/SITT_fact">
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-            </Paths>
-          </Formula>
-          <Formula id="Lumen_Geometry.PARAM_Lumen_Geometry_Length" name="PARAM_Lumen_Geometry_Length" dim="Length" formula="L_p0 + Height*L_p1">
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-              <Path path="334" as="335" />
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-          </Formula>
-          <Formula id="Lumen_PKSim.PARAM_LiquidTransferRate_duo" name="PARAM_LiquidTransferRate_duo" dim="Flow" formula="w*Liquid*FillLevelFlagNext">
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-              <Path path="246" as="247" dim="51" />
-              <Path path="336" as="261" />
-            </Paths>
-          </Formula>
-          <Formula id="Lumen_PKSim.PARAM_Inflow_Duodenum" name="PARAM_Inflow_Duodenum" dim="Flow" formula="0.02894*V">
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-          </Formula>
-          <Formula id="Lumen_Geometry.PARAM_Lumen_Geometry_Thickness" name="PARAM_Lumen_Geometry_Thickness" dim="Length" formula="Thickness_p1 + Thickness_p2*(1-exp(Thickness_p3*Height))">
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-              <Path path="337" as="338" dim="161" />
-              <Path path="339" as="340" dim="161" />
-              <Path path="341" as="342" dim="343" />
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-          </Formula>
-          <Formula id="MucosaVolume_Human.PARAM_VolumeGutWall_Duodenum" name="PARAM_VolumeGutWall_Duodenum" dim="Volume" formula="V_Intestine * 0.087">
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-          </Formula>
-          <Formula id="Lumen_PKSim.LiquidRHS_duo" name="LiquidRHS_duo" dim="Flow" formula="OralApplicationsEnabled ? LT_sto - LT_duo + Inflow*FillLevelFlag - Outflow*Liquid : 0">
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-              <Path path="246" as="247" dim="51" />
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-              <Path path="256" as="257" />
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-          </Formula>
-          <Formula id="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_duo" name="PARAM_OralMassAbsorbed_RHS_duo" dim="Amount per time" formula="PassiveRates_para+PassiveRates_trans-(ActiveRates_para+ActiveRates_trans)">
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-              <Path path="352" as="353" dim="351" />
-              <Path path="354" as="355" dim="351" />
-              <Path path="356" as="357" dim="351" />
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-          </Formula>
-          <Formula id="Lumen_PKSim.PARAM_LiquidTransferRate_uje" name="PARAM_LiquidTransferRate_uje" dim="Flow" formula="w*Liquid*FillLevelFlagNext">
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-              <Path path="246" as="247" dim="51" />
-              <Path path="358" as="261" />
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-          </Formula>
-          <Formula id="Lumen_PKSim.PARAM_Inflow_UpperJejunum" name="PARAM_Inflow_UpperJejunum" dim="Flow" formula="0.0031572*V">
-            <Paths>
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-            </Paths>
-          </Formula>
-          <Formula id="MucosaVolume_Human.PARAM_VolumeGutWall_UpperJejunum" name="PARAM_VolumeGutWall_UpperJejunum" dim="Volume" formula="V_Intestine * 0.249">
-            <Paths>
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-            </Paths>
-          </Formula>
-          <Formula id="Lumen_PKSim.PARAM_InverseSITT_Factor_UpperJejunum" name="PARAM_InverseSITT_Factor_UpperJejunum" dim="Inversed time" formula="LuminalVelocity/SITT_fact">
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-              <Path path="330" as="331" />
-            </Paths>
-          </Formula>
-          <Formula id="Lumen_PKSim.LiquidRHS_uje" name="LiquidRHS_uje" dim="Flow" formula="OralApplicationsEnabled ? LT_duo - LT_uje + Inflow*FillLevelFlag - Outflow*Liquid : 0">
-            <Paths>
-              <Path path="345" as="346" dim="46" />
-              <Path path="250" as="251" />
-              <Path path="246" as="247" dim="51" />
-              <Path path="252" as="359" dim="220" />
-              <Path path="254" as="255" dim="220" />
-              <Path path="360" as="347" dim="220" />
-              <Path path="256" as="257" />
-            </Paths>
-          </Formula>
-          <Formula id="Lumen_PKSim.PARAM_Outflow_UpperJejunum" name="PARAM_Outflow_UpperJejunum" dim="Inversed time" formula="(k_p*alpha_p*V_p+inflow-k*alpha*V)/(alpha*V)">
-            <Paths>
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-              <Path path="258" as="316" dim="46" />
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-              <Path path="362" as="321" dim="46" />
-              <Path path="363" as="323" dim="51" />
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-          </Formula>
-          <Formula id="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_uje" name="PARAM_OralMassAbsorbed_RHS_uje" dim="Amount per time" formula="PassiveRates_para+PassiveRates_trans-(ActiveRates_para+ActiveRates_trans)">
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-              <Path path="365" as="353" dim="351" />
-              <Path path="366" as="355" dim="351" />
-              <Path path="367" as="357" dim="351" />
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-          </Formula>
-          <Formula id="MucosaVolume_Human.PARAM_VolumeGutWall_LowerJejunum" name="PARAM_VolumeGutWall_LowerJejunum" dim="Volume" formula="V_Intestine * 0.184">
-            <Paths>
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-            </Paths>
-          </Formula>
-          <Formula id="Lumen_PKSim.PARAM_Outflow_LowerJejunum" name="PARAM_Outflow_LowerJejunum" dim="Inversed time" formula="(k_p*alpha_p*V_p+inflow-k*alpha*V)/(alpha*V)">
-            <Paths>
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-              <Path path="258" as="316" dim="46" />
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-              <Path path="166" as="170" dim="51" />
-              <Path path="368" as="319" dim="20" />
-              <Path path="369" as="321" dim="46" />
-              <Path path="370" as="323" dim="51" />
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-          </Formula>
-          <Formula id="Lumen_PKSim.PARAM_InverseSITT_Factor_LowerJejunum" name="PARAM_InverseSITT_Factor_LowerJejunum" dim="Inversed time" formula="LuminalVelocity/SITT_fact">
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-              <Path path="330" as="331" />
-            </Paths>
-          </Formula>
-          <Formula id="Lumen_PKSim.LiquidRHS_lje" name="LiquidRHS_lje" dim="Flow" formula="OralApplicationsEnabled ? LT_uje - LT_lje + Inflow*FillLevelFlag - Outflow*Liquid : 0">
-            <Paths>
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-              <Path path="250" as="251" />
-              <Path path="246" as="247" dim="51" />
-              <Path path="252" as="371" dim="220" />
-              <Path path="254" as="255" dim="220" />
-              <Path path="372" as="359" dim="220" />
-              <Path path="256" as="257" />
-            </Paths>
-          </Formula>
-          <Formula id="Lumen_PKSim.PARAM_LiquidTransferRate_lje" name="PARAM_LiquidTransferRate_lje" dim="Flow" formula="w*Liquid*FillLevelFlagNext">
-            <Paths>
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-              <Path path="246" as="247" dim="51" />
-              <Path path="373" as="261" />
-            </Paths>
-          </Formula>
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-          </Formula>
-          <Formula id="Lumen_PKSim.PARAM_LiquidTransferRate_rect" name="PARAM_LiquidTransferRate_rect" dim="Flow" formula="w*Liquid">
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-          </Formula>
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-            </Paths>
-          </Formula>
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-          </Formula>
-          <Formula id="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_rect" name="PARAM_OralMassAbsorbed_RHS_rect" dim="Amount per time" formula="PassiveRates_para+PassiveRates_trans-(ActiveRates_para+ActiveRates_trans)">
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-          </Formula>
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-          </Formula>
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-          </Formula>
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-          </Formula>
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-          </Formula>
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-            </Paths>
-          </Formula>
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-            <Paths>
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-          </Formula>
-          <Formula id="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate_(incl._mucosa)_SmallIntestine" name="PARAM_Fluid_recirculation_flow_rate_(incl._mucosa)_SmallIntestine" dim="Flow" formula="0.00000000421*(BW/0.02)^0.75">
-            <Paths>
-              <Path path="162" as="163" dim="118" />
-            </Paths>
-          </Formula>
-          <Formula id="Individual_PKSim.PARAM_FluidRecirculationRate_sin" name="PARAM_FluidRecirculationRate_sin" dim="Flow" formula="J_iso_incl_Mucosa-J_iso_duo-J_iso_uje-J_iso_lje-J_iso_uil-J_iso_lil">
-            <Paths>
-              <Path path="483" as="484" dim="220" />
-              <Path path="485" as="486" dim="220" />
-              <Path path="487" as="488" dim="220" />
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-              <Path path="493" as="494" dim="220" />
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-          </Formula>
-          <Formula id="MucosaVolume.VOLUME_SmallIntestineMucosa" name="VOLUME_SmallIntestineMucosa" dim="Volume" formula="V_duo+V_uje+V_lje+V_uil+V_lil">
-            <Paths>
-              <Path path="495" as="496" dim="51" />
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-              <Path path="503" as="504" dim="51" />
-            </Paths>
-          </Formula>
-          <Formula id="CompartmentsVolume_4Comp.VOLUME_pls_SinLin" name="VOLUME_pls_SinLin" dim="Volume" formula="f_vas*(1-HCT)*(V-V_Mucosa)">
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-              <Path path="169" as="170" dim="51" />
-              <Path path="505" as="506" dim="51" />
-              <Path path="36" as="37" />
-            </Paths>
-          </Formula>
-          <Formula id="CompartmentsVolume_4Comp.VOLUME_bc_SinLin" name="VOLUME_bc_SinLin" dim="Volume" formula="f_vas*HCT*(V-V_Mucosa)">
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-              <Path path="169" as="170" dim="51" />
-              <Path path="505" as="506" dim="51" />
-              <Path path="36" as="37" />
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-          </Formula>
-          <Formula id="CompartmentsVolume_4Comp.VOLUME_int_SinLin" name="VOLUME_int_SinLin" dim="Volume" formula="f_int*(V-V_Mucosa)">
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-              <Path path="192" as="189" />
-              <Path path="169" as="170" dim="51" />
-              <Path path="505" as="506" dim="51" />
-            </Paths>
-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_sin" name="PARAM_K_Water_INT_sin" dim="Dimensionless" formula="K_water_int">
-            <Paths>
-              <Path path="507" as="196" />
-            </Paths>
-          </Formula>
-          <Formula id="CompoundCommon.PARAM_ProteinContainerVolume_Organ_SinLin" name="PARAM_ProteinContainerVolume_Organ_SinLin" dim="Volume" formula="Volume-V_Mucosa">
-            <Paths>
-              <Path path="169" as="51" dim="51" />
-              <Path path="505" as="506" dim="51" />
-            </Paths>
-          </Formula>
-          <Formula id="CompartmentsVolume_4Comp.VOLUME_cell_SinLin" name="VOLUME_cell_SinLin" dim="Volume" formula="f_cell*(V-V_Mucosa)">
-            <Paths>
-              <Path path="197" as="198" />
-              <Path path="169" as="170" dim="51" />
-              <Path path="505" as="506" dim="51" />
-            </Paths>
-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_sin" name="PARAM_K_Water_CELL_sin" dim="Dimensionless" formula="K_water_cell">
-            <Paths>
-              <Path path="508" as="200" />
-            </Paths>
-          </Formula>
-          <Formula id="MucosaVolume.VOLUME_MucosaDuodenum" name="VOLUME_MucosaDuodenum" dim="Volume" formula="V_GutWall*fractionMucosa">
-            <Paths>
-              <Path path="509" as="510" />
-              <Path path="511" as="512" dim="51" />
-            </Paths>
-          </Formula>
-          <Formula id="VascularEndoVolume.VOLUME_VascularEndo_duo" name="VOLUME_VascularEndo_duo" dim="Volume" formula="SA_pls_int*d_endo">
-            <Paths>
-              <Path path="183" as="184" dim="161" />
-              <Path path="513" as="186" dim="187" />
-            </Paths>
-          </Formula>
-          <Formula id="Individual_PKSim.PARAM_Q_lymph_mucosa" name="PARAM_Q_lymph_mucosa" dim="Flow" formula="Q_lymph_intestine * V_seg / V_intestine">
-            <Paths>
-              <Path path="514" as="515" dim="220" />
-              <Path path="516" as="517" dim="51" />
-              <Path path="166" as="518" dim="51" />
-            </Paths>
-          </Formula>
-          <Formula id="Individual_PKSim.PARAM_J_iso_Mucosa" name="PARAM_J_iso_Mucosa" dim="Flow" formula="J_iso_intestine * V_seg / V_intestine">
-            <Paths>
-              <Path path="519" as="520" dim="220" />
-              <Path path="516" as="517" dim="51" />
-              <Path path="166" as="518" dim="51" />
-            </Paths>
-          </Formula>
-          <Formula id="Individual_PKSim.PARAM_Q_mucosa" name="PARAM_Q_mucosa" dim="Flow" formula="Q * fractQ * regionalFractQ">
-            <Paths>
-              <Path path="521" as="522" dim="220" />
-              <Path path="523" as="524" />
-              <Path path="525" as="526" />
-            </Paths>
-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_duo" name="PARAM_K_Water_INT_duo" dim="Dimensionless" formula="K_water_int">
-            <Paths>
-              <Path path="527" as="196" />
-            </Paths>
-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_duo" name="PARAM_K_Water_CELL_duo" dim="Dimensionless" formula="K_water_cell">
-            <Paths>
-              <Path path="528" as="200" />
-            </Paths>
-          </Formula>
-          <Formula id="MucosaVolume.VOLUME_MucosaUpperJejunum" name="VOLUME_MucosaUpperJejunum" dim="Volume" formula="V_GutWall*fractionMucosa">
-            <Paths>
-              <Path path="509" as="510" />
-              <Path path="529" as="512" dim="51" />
-            </Paths>
-          </Formula>
-          <Formula id="VascularEndoVolume.VOLUME_VascularEndo_uje" name="VOLUME_VascularEndo_uje" dim="Volume" formula="SA_pls_int*d_endo">
-            <Paths>
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-              <Path path="530" as="186" dim="187" />
-            </Paths>
-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_uje" name="PARAM_K_Water_INT_uje" dim="Dimensionless" formula="K_water_int">
-            <Paths>
-              <Path path="531" as="196" />
-            </Paths>
-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_uje" name="PARAM_K_Water_CELL_uje" dim="Dimensionless" formula="K_water_cell">
-            <Paths>
-              <Path path="532" as="200" />
-            </Paths>
-          </Formula>
-          <Formula id="MucosaVolume.VOLUME_MucosaLowerJejunum" name="VOLUME_MucosaLowerJejunum" dim="Volume" formula="V_GutWall*fractionMucosa">
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-              <Path path="533" as="512" dim="51" />
-            </Paths>
-          </Formula>
-          <Formula id="VascularEndoVolume.VOLUME_VascularEndo_lje" name="VOLUME_VascularEndo_lje" dim="Volume" formula="SA_pls_int*d_endo">
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-              <Path path="534" as="186" dim="187" />
-            </Paths>
-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_lje" name="PARAM_K_Water_INT_lje" dim="Dimensionless" formula="K_water_int">
-            <Paths>
-              <Path path="535" as="196" />
-            </Paths>
-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_lje" name="PARAM_K_Water_CELL_lje" dim="Dimensionless" formula="K_water_cell">
-            <Paths>
-              <Path path="536" as="200" />
-            </Paths>
-          </Formula>
-          <Formula id="MucosaVolume.VOLUME_MucosaUpperIleum" name="VOLUME_MucosaUpperIleum" dim="Volume" formula="V_GutWall*fractionMucosa">
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-          </Formula>
-          <Formula id="VascularEndoVolume.VOLUME_VascularEndo_uil" name="VOLUME_VascularEndo_uil" dim="Volume" formula="SA_pls_int*d_endo">
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-              <Path path="538" as="186" dim="187" />
-            </Paths>
-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_uil" name="PARAM_K_Water_INT_uil" dim="Dimensionless" formula="K_water_int">
-            <Paths>
-              <Path path="539" as="196" />
-            </Paths>
-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_uil" name="PARAM_K_Water_CELL_uil" dim="Dimensionless" formula="K_water_cell">
-            <Paths>
-              <Path path="540" as="200" />
-            </Paths>
-          </Formula>
-          <Formula id="MucosaVolume.VOLUME_MucosaLowerIleum" name="VOLUME_MucosaLowerIleum" dim="Volume" formula="V_GutWall*fractionMucosa">
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-              <Path path="541" as="512" dim="51" />
-            </Paths>
-          </Formula>
-          <Formula id="VascularEndoVolume.VOLUME_VascularEndo_lil" name="VOLUME_VascularEndo_lil" dim="Volume" formula="SA_pls_int*d_endo">
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-              <Path path="542" as="186" dim="187" />
-            </Paths>
-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_lil" name="PARAM_K_Water_INT_lil" dim="Dimensionless" formula="K_water_int">
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-            </Paths>
-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_lil" name="PARAM_K_Water_CELL_lil" dim="Dimensionless" formula="K_water_cell">
-            <Paths>
-              <Path path="544" as="200" />
-            </Paths>
-          </Formula>
-          <Formula id="MucosaVolume.VOLUME_LargeIntestineMucosa" name="VOLUME_LargeIntestineMucosa" dim="Volume" formula="V_cae+V_ca+V_ct+V_cd+V_cs+V_rec">
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-              <Path path="547" as="548" dim="51" />
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-              <Path path="553" as="554" dim="51" />
-              <Path path="555" as="556" dim="51" />
-            </Paths>
-          </Formula>
-          <Formula id="Lumen_PKSim.PARAM_LITT_Factor" name="PARAM_LITT_Factor" dim="Dimensionless" formula="P1*LITT+P2">
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-              <Path path="559" as="467" />
-              <Path path="560" as="469" dim="46" />
-            </Paths>
-          </Formula>
-          <Formula id="Individual_PKSim.PARAM_FluidRecirculationRate_lin" name="PARAM_FluidRecirculationRate_lin" dim="Flow" formula="J_iso_incl_Mucosa-J_iso_cae-J_iso_colasc-J_iso_coltrans-J_iso_coldesc-J_iso_colsigm-J_iso_rect">
-            <Paths>
-              <Path path="483" as="484" dim="220" />
-              <Path path="561" as="562" dim="220" />
-              <Path path="563" as="564" dim="220" />
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-              <Path path="569" as="570" dim="220" />
-              <Path path="571" as="572" dim="220" />
-            </Paths>
-          </Formula>
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-            <Paths>
-              <Path path="162" as="163" dim="118" />
-            </Paths>
-          </Formula>
-          <Formula id="Individual_PKSim.PARAM_Q_Lymph_lin" name="PARAM_Q_Lymph_lin" dim="Flow" formula="Q_lymph_incl_Mucosa-Q_lymph_cae-Q_lymph_colasc-Q_lymph_coltrans-Q_lymph_coldesc-Q_lymph_colsigm-Q_lymph_rect">
-            <Paths>
-              <Path path="470" as="471" dim="220" />
-              <Path path="573" as="574" dim="220" />
-              <Path path="575" as="576" dim="220" />
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-              <Path path="581" as="582" dim="220" />
-              <Path path="583" as="584" dim="220" />
-            </Paths>
-          </Formula>
-          <Formula id="Individual_PKSim.PARAM_Lymph_flow_rate_(incl._mucosa)_LargeIntestine" name="PARAM_Lymph_flow_rate_(incl._mucosa)_LargeIntestine" dim="Flow" formula="0.00000034*BW/0.02">
-            <Paths>
-              <Path path="162" as="163" dim="118" />
-            </Paths>
-          </Formula>
-          <Formula id="VascularEndoVolume.VOLUME_VascularEndo_lin" name="VOLUME_VascularEndo_lin" dim="Volume" formula="SA_pls_int*d_endo">
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-              <Path path="585" as="186" dim="187" />
-            </Paths>
-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_lin" name="PARAM_K_Water_INT_lin" dim="Dimensionless" formula="K_water_int">
-            <Paths>
-              <Path path="586" as="196" />
-            </Paths>
-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_lin" name="PARAM_K_Water_CELL_lin" dim="Dimensionless" formula="K_water_cell">
-            <Paths>
-              <Path path="587" as="200" />
-            </Paths>
-          </Formula>
-          <Formula id="MucosaVolume.VOLUME_MucosaCaecum" name="VOLUME_MucosaCaecum" dim="Volume" formula="V_GutWall*fractionMucosa">
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-              <Path path="588" as="512" dim="51" />
-            </Paths>
-          </Formula>
-          <Formula id="VascularEndoVolume.VOLUME_VascularEndo_cae" name="VOLUME_VascularEndo_cae" dim="Volume" formula="SA_pls_int*d_endo">
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-              <Path path="589" as="186" dim="187" />
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-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_cae" name="PARAM_K_Water_INT_cae" dim="Dimensionless" formula="K_water_int">
-            <Paths>
-              <Path path="590" as="196" />
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-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_cae" name="PARAM_K_Water_CELL_cae" dim="Dimensionless" formula="K_water_cell">
-            <Paths>
-              <Path path="591" as="200" />
-            </Paths>
-          </Formula>
-          <Formula id="MucosaVolume.VOLUME_MucosaColonAscendens" name="VOLUME_MucosaColonAscendens" dim="Volume" formula="V_GutWall*fractionMucosa">
-            <Paths>
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-              <Path path="592" as="512" dim="51" />
-            </Paths>
-          </Formula>
-          <Formula id="VascularEndoVolume.VOLUME_VascularEndo_colasc" name="VOLUME_VascularEndo_colasc" dim="Volume" formula="SA_pls_int*d_endo">
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-              <Path path="593" as="186" dim="187" />
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-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_colasc" name="PARAM_K_Water_INT_colasc" dim="Dimensionless" formula="K_water_int">
-            <Paths>
-              <Path path="594" as="196" />
-            </Paths>
-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_colasc" name="PARAM_K_Water_CELL_colasc" dim="Dimensionless" formula="K_water_cell">
-            <Paths>
-              <Path path="595" as="200" />
-            </Paths>
-          </Formula>
-          <Formula id="MucosaVolume.VOLUME_MucosaColonTransversum" name="VOLUME_MucosaColonTransversum" dim="Volume" formula="V_GutWall*fractionMucosa">
-            <Paths>
-              <Path path="509" as="510" />
-              <Path path="596" as="512" dim="51" />
-            </Paths>
-          </Formula>
-          <Formula id="VascularEndoVolume.VOLUME_VascularEndo_coltrans" name="VOLUME_VascularEndo_coltrans" dim="Volume" formula="SA_pls_int*d_endo">
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-              <Path path="183" as="184" dim="161" />
-              <Path path="597" as="186" dim="187" />
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-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_coltrans" name="PARAM_K_Water_INT_coltrans" dim="Dimensionless" formula="K_water_int">
-            <Paths>
-              <Path path="598" as="196" />
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-          </Formula>
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-          </Formula>
-          <Formula id="Individual_PKSim.PARAM_Q_lng" name="PARAM_Q_lng" dim="Flow" formula="Q_sto + Q_sin + Q_lin + Q_pan + Q_spl + Q_liv + Q_mus + Q_fat + Q_skn + Q_kid + Q_brn + Q_hrt + Q_bon + Q_tes">
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-          </Formula>
-          <Formula id="Individual_PKSim.PARAM_Lymph_flow_rate_Muscle" name="PARAM_Lymph_flow_rate_Muscle" dim="Flow" formula="0.00000055*BW/0.02">
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-            </Paths>
-          </Formula>
-          <Formula id="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate_Muscle" name="PARAM_Fluid_recirculation_flow_rate_Muscle" dim="Flow" formula="0.000000111*(BW/0.02)^0.75">
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-          </Formula>
-          <Formula id="VascularEndoVolume.VOLUME_VascularEndo_mus" name="VOLUME_VascularEndo_mus" dim="Volume" formula="SA_pls_int*d_endo">
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-          </Formula>
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-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_mus" name="PARAM_K_Water_CELL_mus" dim="Dimensionless" formula="K_water_cell">
-            <Paths>
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-          </Formula>
-          <Formula id="VascularEndoVolume.VOLUME_VascularEndo_pan" name="VOLUME_VascularEndo_pan" dim="Volume" formula="SA_pls_int*d_endo">
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-          </Formula>
-          <Formula id="Individual_PKSim.PARAM_Lymph_flow_rate_Pancreas" name="PARAM_Lymph_flow_rate_Pancreas" dim="Flow" formula="0.00000065*BW/0.02">
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-          </Formula>
-          <Formula id="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate_Pancreas" name="PARAM_Fluid_recirculation_flow_rate_Pancreas" dim="Flow" formula="0.0000000872*(BW/0.02)^0.75">
-            <Paths>
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-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_pan" name="PARAM_K_Water_INT_pan" dim="Dimensionless" formula="K_water_int">
-            <Paths>
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-            </Paths>
-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_pan" name="PARAM_K_Water_CELL_pan" dim="Dimensionless" formula="K_water_cell">
-            <Paths>
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-            </Paths>
-          </Formula>
-          <Formula id="Individual_PKSim.PARAM_Q_Lymph_pve" name="PARAM_Q_Lymph_pve" dim="Flow" formula="Q_Lymph_sto + Q_Lymph_sin_incl_Mucosa + Q_Lymph_lin_incl_Mucosa + Q_Lymph_pan + Q_Lymph_spl">
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-          <Formula id="Individual_PKSim.PARAM_Q_pve" name="PARAM_Q_pve" dim="Flow" formula="Q_sto + Q_sin + Q_lin + Q_pan + Q_spl">
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-          </Formula>
-          <Formula id="VascularEndoVolume.VOLUME_VascularEndo_skn" name="VOLUME_VascularEndo_skn" dim="Volume" formula="SA_pls_int*d_endo">
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-          </Formula>
-          <Formula id="Individual_PKSim.PARAM_Fluid_recirculation_flow_rate_Skin" name="PARAM_Fluid_recirculation_flow_rate_Skin" dim="Flow" formula="0.000000342*(BW/0.02)^0.75">
-            <Paths>
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-          </Formula>
-          <Formula id="Individual_PKSim.PARAM_Lymph_flow_rate_Skin" name="PARAM_Lymph_flow_rate_Skin" dim="Flow" formula="0.00000051*BW/0.02">
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-            </Paths>
-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_skn" name="PARAM_K_Water_INT_skn" dim="Dimensionless" formula="K_water_int">
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-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_skn" name="PARAM_K_Water_CELL_skn" dim="Dimensionless" formula="K_water_cell">
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-          </Formula>
-          <Formula id="Individual_PKSim.PARAM_Lymph_flow_rate_Spleen" name="PARAM_Lymph_flow_rate_Spleen" dim="Flow" formula="0.000008*BW/0.02">
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-          </Formula>
-          <Formula id="VascularEndoVolume.VOLUME_VascularEndo_spl" name="VOLUME_VascularEndo_spl" dim="Volume" formula="SA_pls_int*d_endo">
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-          </Formula>
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-          <Formula id="Individual_PKSim.VOLUME_Saliva_Organ" name="VOLUME_Saliva_Organ" dim="Volume" formula="0.006 * BW / 73">
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-          </Formula>
-          <Formula id="CompartmentsVolume_4Comp.VOLUME_slv_slv" name="VOLUME_slv_slv" dim="Volume" formula="V_slv">
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-          </Formula>
-          <Formula id="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls_Blood_Organ" name="PARAM_SA_rbc_pls_Blood_Organ" dim="Area" formula="HCT * A_to_V_bc * 0.6 * V">
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-          </Formula>
-          <Formula id="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" name="PARAM_SA_pls_int" dim="Area" formula="k * f_vas_org * V_org">
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-          <BlackBoxFormula id="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" name="INTERSTITIAL PARTITION COEFFICIENT FORMULA" dim="Dimensionless" />
-          <Formula id="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" name="PARAM_SA_rbc_pls" dim="Area" formula="HCT * A_to_V_bc * 0.6 * V * f_vas">
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-          <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_bon" name="PARAM_SA_int_cell_bon" dim="Area" formula="(V_bon * 1000 / 28.2)^0.75 * 10 * 1E2">
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-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_wat_cell" name="PARAM_K_wat_cell" dim="Dimensionless" formula="fu/K_cell_pls">
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-            </Paths>
-          </Formula>
-          <Formula id="DiffusionCommon_PKSim.PARAM_P_int_cell" name="PARAM_P_int_cell" dim="Velocity" formula="P * P_int_cell_factor">
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-          </Formula>
-          <Formula id="DiffusionCommon_PKSim.PARAM_P_cell_int" name="PARAM_P_cell_int" dim="Velocity" formula="P * P_cell_int_factor">
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-          <Formula id="DiffusionCommon_PKSim.PARAM_PA_int_cell" name="PARAM_PA_int_cell" dim="Flow" formula="P_int_cell * SA">
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-          </Formula>
-          <Formula id="DiffusionCommon_PKSim.PARAM_PA_cell_int" name="PARAM_PA_cell_int" dim="Flow" formula="P_cell_int * SA">
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-          </Formula>
-          <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_brn" name="PARAM_SA_int_cell_brn" dim="Area" formula="(V_brn  * 1000 / 1.671)^0.75 * 0.0006 * 1E2">
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-          </Formula>
-          <Formula id="DiffusionPlasma_PKSim.PARAM_P_endothelial_Brain" name="PARAM_P_endothelial_Brain" dim="Velocity" formula="P/2">
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-          </Formula>
-          <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_fat" name="PARAM_SA_int_cell_fat" dim="Area" formula="(V_fat * 1000 / 14.2)^0.75 * 5 * 1E2">
-            <Paths>
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-          </Formula>
-          <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_tes" name="PARAM_SA_int_cell_tes" dim="Area" formula="(V_tes * 1000 / 2.5)^0.75 * 2 * 1E2">
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-          </Formula>
-          <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_hrt" name="PARAM_SA_int_cell_hrt" dim="Area" formula="(V_hrt * 1000 / 1.2)^0.75 * 7.54 * 1E2">
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-          </Formula>
-          <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_kid" name="PARAM_SA_int_cell_kid" dim="Area" formula="(V_kid * 1000 / 7)^0.75 * 1000 * 1E2">
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-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_water_cell_Kidney" name="PARAM_K_water_cell_Kidney" dim="Dimensionless" formula="K_water_cell">
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-          </Formula>
-          <Formula id="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPvePlasma" name="PARAM_MassTransferMucosaToPvePlasma" dim="Amount per time" formula="Q*(1-HCT)*C_pls">
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-          </Formula>
-          <SumFormula id="DynamicSumFormulas.PARAM_SumOfActiveProcessRates" name="PARAM_SumOfActiveProcessRates" dim="Amount per time" variable="P" formulaString="P_#i">
-            <Criteria>
-              <DescriptorConditions>
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-                <MatchTagCondition tag="MOLECULE" />
-                <MatchTagCondition tag="NEIGHBORHOOD" />
-                <MatchTagCondition tag="ProcessRate" />
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-              <DescriptorConditions>
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-                <MatchTagCondition tag="NEIGHBORHOOD" />
-                <MatchTagCondition tag="Passive" />
-                <MatchTagCondition tag="ProcessRate" />
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-            </Criteria>
-          </SumFormula>
-          <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K6" name="PARAM_pKa_pH_WS_lum_K6" dim="Dimensionless" formula="(1-F1)*F2*(1-F3)">
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-              <Path path="264" as="265" />
-              <Path path="266" as="267" />
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-          <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K5" name="PARAM_pKa_pH_WS_mucosacell_K5" dim="Dimensionless" formula="(1-F1)*(1-F2)*F3">
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-              <Path path="694" as="267" />
-            </Paths>
-          </Formula>
-          <Formula id="Lumen_PKSim.PARAM_DrugAbsorption_trans" name="PARAM_DrugAbsorption_trans" dim="Amount per time" formula="OralApplicationsEnabled ? P_int_trans*Ageom*AeffFactor*(P_int_trans_lum_cell_factor*min(Solubility/ MW ;DrugLiquid/(Liquid))-(NOT SinkCondition_trans ? P_int_trans_cell_lum_factor*fu/K_cell_pls*DrugMucosa : 0)) : 0">
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-              <Path path="705" as="6" dim="2" />
-              <Path path="706" as="707" dim="708" />
-              <Path path="709" as="710" />
-              <Path path="711" as="712" />
-              <Path path="713" as="306" dim="307" />
-              <Path path="714" as="257" />
-              <Path path="715" as="716" />
-            </Paths>
-          </Formula>
-          <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_cell_lum_factor" name="PARAM_P_int_trans_cell_lum_factor" dim="Dimensionless" formula="UsePenaltyFactor ? K1+ (K2 +K3 +K4)* base ^ 1 + K5* base ^ max(CT0+CT1;-CT0-CT1) +K6* base ^ max(CT0+CT2;-CT0-CT2) +K7* base ^ max(CT2+CT1;-CT2-CT1) +K8* base ^ max(CT0+CT1+CT2;-CT0-CT1-CT2) : 1">
-            <Paths>
-              <Path path="717" as="286" />
-              <Path path="718" as="288" />
-              <Path path="719" as="290" />
-              <Path path="720" as="292" />
-              <Path path="721" as="294" />
-              <Path path="722" as="296" />
-              <Path path="723" as="298" />
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-              <Path path="725" as="302" />
-              <Path path="280" as="281" />
-              <Path path="276" as="277" />
-              <Path path="268" as="269" />
-              <Path path="726" as="727" />
-            </Paths>
-          </Formula>
-          <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_lum_cell_factor" name="PARAM_P_int_trans_lum_cell_factor" dim="Dimensionless" formula="UsePenaltyFactor ? K1+ (K2 +K3 +K4)* base ^ 1 + K5* base ^ max(CT0+CT1;-CT0-CT1) +K6* base ^ max(CT0+CT2;-CT0-CT2) +K7* base ^ max(CT2+CT1;-CT2-CT1) +K8* base ^ max(CT0+CT1+CT2;-CT0-CT1-CT2) : 1">
-            <Paths>
-              <Path path="285" as="286" />
-              <Path path="287" as="288" />
-              <Path path="289" as="290" />
-              <Path path="291" as="292" />
-              <Path path="293" as="294" />
-              <Path path="295" as="296" />
-              <Path path="297" as="298" />
-              <Path path="299" as="300" />
-              <Path path="725" as="302" />
-              <Path path="280" as="281" />
-              <Path path="276" as="277" />
-              <Path path="268" as="269" />
-              <Path path="726" as="727" />
-            </Paths>
-          </Formula>
-          <Formula id="Lumen_PKSim.PARAM_K_cell_pls_UpperJejunum" name="PARAM_K_cell_pls_UpperJejunum" dim="Dimensionless" formula="K_cell_pls">
-            <Paths>
-              <Path path="728" as="677" />
-            </Paths>
-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_UpperJejunum" name="PARAM_K_wat_cell_Lumen_UpperJejunum" dim="Dimensionless" formula="K_water_cell">
-            <Paths>
-              <Path path="532" as="200" />
-            </Paths>
-          </Formula>
-          <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F1" name="PARAM_pKa_pH_WS_mucosacell_F1" dim="Dimensionless" formula="CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1">
-            <Paths>
-              <Path path="280" as="281" />
-              <Path path="270" as="271" />
-              <Path path="282" as="283" />
-              <Path path="729" as="275" />
-            </Paths>
-          </Formula>
-          <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F2" name="PARAM_pKa_pH_WS_mucosacell_F2" dim="Dimensionless" formula="CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1">
-            <Paths>
-              <Path path="276" as="277" />
-              <Path path="270" as="271" />
-              <Path path="278" as="279" />
-              <Path path="729" as="275" />
-            </Paths>
-          </Formula>
-          <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F3" name="PARAM_pKa_pH_WS_mucosacell_F3" dim="Dimensionless" formula="CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1">
-            <Paths>
-              <Path path="268" as="269" />
-              <Path path="270" as="271" />
-              <Path path="272" as="273" />
-              <Path path="729" as="275" />
-            </Paths>
-          </Formula>
-          <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K1" name="PARAM_pKa_pH_WS_mucosacell_K1" dim="Dimensionless" formula="F1*F2*F3">
-            <Paths>
-              <Path path="692" as="263" />
-              <Path path="693" as="265" />
-              <Path path="694" as="267" />
-            </Paths>
-          </Formula>
-          <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K2" name="PARAM_pKa_pH_WS_mucosacell_K2" dim="Dimensionless" formula="(1-F1)*F2*F3">
-            <Paths>
-              <Path path="692" as="263" />
-              <Path path="693" as="265" />
-              <Path path="694" as="267" />
-            </Paths>
-          </Formula>
-          <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K8" name="PARAM_pKa_pH_WS_lum_K8" dim="Dimensionless" formula="(1-F1)*(1-F2)*(1-F3)">
-            <Paths>
-              <Path path="262" as="263" />
-              <Path path="264" as="265" />
-              <Path path="266" as="267" />
-            </Paths>
-          </Formula>
-          <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K4" name="PARAM_pKa_pH_WS_mucosacell_K4" dim="Dimensionless" formula="F1*F2*(1-F3)">
-            <Paths>
-              <Path path="692" as="263" />
-              <Path path="693" as="265" />
-              <Path path="694" as="267" />
-            </Paths>
-          </Formula>
-          <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K7" name="PARAM_pKa_pH_WS_lum_K7" dim="Dimensionless" formula="F1*(1-F2)*(1-F3)">
-            <Paths>
-              <Path path="262" as="263" />
-              <Path path="264" as="265" />
-              <Path path="266" as="267" />
-            </Paths>
-          </Formula>
-          <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K6" name="PARAM_pKa_pH_WS_mucosacell_K6" dim="Dimensionless" formula="(1-F1)*F2*(1-F3)">
-            <Paths>
-              <Path path="692" as="263" />
-              <Path path="693" as="265" />
-              <Path path="694" as="267" />
-            </Paths>
-          </Formula>
-          <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K7" name="PARAM_pKa_pH_WS_mucosacell_K7" dim="Dimensionless" formula="F1*(1-F2)*(1-F3)">
-            <Paths>
-              <Path path="692" as="263" />
-              <Path path="693" as="265" />
-              <Path path="694" as="267" />
-            </Paths>
-          </Formula>
-          <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K8" name="PARAM_pKa_pH_WS_mucosacell_K8" dim="Dimensionless" formula="(1-F1)*(1-F2)*(1-F3)">
-            <Paths>
-              <Path path="692" as="263" />
-              <Path path="693" as="265" />
-              <Path path="694" as="267" />
-            </Paths>
-          </Formula>
-          <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F1" name="PARAM_pKa_pH_WS_lum_F1" dim="Dimensionless" formula="CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1">
-            <Paths>
-              <Path path="730" as="275" />
-              <Path path="280" as="281" />
-              <Path path="270" as="271" />
-              <Path path="282" as="283" />
-            </Paths>
-          </Formula>
-          <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F2" name="PARAM_pKa_pH_WS_lum_F2" dim="Dimensionless" formula="CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1">
-            <Paths>
-              <Path path="730" as="275" />
-              <Path path="276" as="277" />
-              <Path path="270" as="271" />
-              <Path path="278" as="279" />
-            </Paths>
-          </Formula>
-          <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F3" name="PARAM_pKa_pH_WS_lum_F3" dim="Dimensionless" formula="CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1">
-            <Paths>
-              <Path path="730" as="275" />
-              <Path path="268" as="269" />
-              <Path path="270" as="271" />
-              <Path path="272" as="273" />
-            </Paths>
-          </Formula>
-          <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K1" name="PARAM_pKa_pH_WS_lum_K1" dim="Dimensionless" formula="F1*F2*F3">
-            <Paths>
-              <Path path="262" as="263" />
-              <Path path="264" as="265" />
-              <Path path="266" as="267" />
-            </Paths>
-          </Formula>
-          <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K2" name="PARAM_pKa_pH_WS_lum_K2" dim="Dimensionless" formula="(1-F1)*F2*F3">
-            <Paths>
-              <Path path="262" as="263" />
-              <Path path="264" as="265" />
-              <Path path="266" as="267" />
-            </Paths>
-          </Formula>
-          <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K3" name="PARAM_pKa_pH_WS_lum_K3" dim="Dimensionless" formula="F1*(1-F2)*F3">
-            <Paths>
-              <Path path="262" as="263" />
-              <Path path="264" as="265" />
-              <Path path="266" as="267" />
-            </Paths>
-          </Formula>
-          <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K4" name="PARAM_pKa_pH_WS_lum_K4" dim="Dimensionless" formula="F1*F2*(1-F3)">
-            <Paths>
-              <Path path="262" as="263" />
-              <Path path="264" as="265" />
-              <Path path="266" as="267" />
-            </Paths>
-          </Formula>
-          <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K5" name="PARAM_pKa_pH_WS_lum_K5" dim="Dimensionless" formula="(1-F1)*(1-F2)*F3">
-            <Paths>
-              <Path path="262" as="263" />
-              <Path path="264" as="265" />
-              <Path path="266" as="267" />
-            </Paths>
-          </Formula>
-          <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K3" name="PARAM_pKa_pH_WS_mucosacell_K3" dim="Dimensionless" formula="F1*(1-F2)*F3">
-            <Paths>
-              <Path path="692" as="263" />
-              <Path path="693" as="265" />
-              <Path path="694" as="267" />
-            </Paths>
-          </Formula>
-          <Formula id="Lumen_PKSim.PARAM_DrugAbsorption_para" name="PARAM_DrugAbsorption_para" dim="Amount per time" formula="OralApplicationsEnabled ? P_int_para*Ageom*AeffFactor*(min(Solubility/ MW ;DrugLiquid/(Liquid))-(NOT SinkCondition_para ? fu*DrugMucosa : 0)) : 0">
-            <Paths>
-              <Path path="695" as="696" />
-              <Path path="697" as="698" dim="187" />
-              <Path path="699" as="247" dim="51" />
-              <Path path="700" as="701" dim="702" />
-              <Path path="703" as="704" dim="690" />
-              <Path path="29" as="30" dim="20" />
-              <Path path="731" as="732" dim="2" />
-              <Path path="706" as="707" dim="708" />
-              <Path path="713" as="306" dim="307" />
-              <Path path="714" as="257" />
-              <Path path="733" as="734" />
-            </Paths>
-          </Formula>
-          <Formula id="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPveBloodCells" name="PARAM_MassTransferMucosaToPveBloodCells" dim="Amount per time" formula="Q*HCT*C_bc">
-            <Paths>
-              <Path path="688" as="735" dim="690" />
-              <Path path="691" as="522" dim="220" />
-              <Path path="36" as="37" />
-            </Paths>
-          </Formula>
-          <Formula id="Lumen_PKSim.PARAM_OralMassAbsorbed" name="PARAM_OralMassAbsorbed" dim="Amount" formula="MAbs_duo + MAbs_uje + MAbs_lje + MAbs_uil + MAbs_lil + MAbs_cae + MAbs_colasc + MAbs_coltrans + MAbs_coldesc + MAbs_colsigm + MAbs_rect">
-            <Paths>
-              <Path path="736" as="737" dim="702" />
-              <Path path="738" as="739" dim="702" />
-              <Path path="740" as="741" dim="702" />
-              <Path path="742" as="743" dim="702" />
-              <Path path="744" as="745" dim="702" />
-              <Path path="746" as="747" dim="702" />
-              <Path path="748" as="749" dim="702" />
-              <Path path="750" as="751" dim="702" />
-              <Path path="752" as="753" dim="702" />
-              <Path path="754" as="755" dim="702" />
-              <Path path="756" as="757" dim="702" />
-            </Paths>
-          </Formula>
-          <Formula id="Lumen_PKSim.PARAM_K_cell_pls_LowerJejunum" name="PARAM_K_cell_pls_LowerJejunum" dim="Dimensionless" formula="K_cell_pls">
-            <Paths>
-              <Path path="758" as="677" />
-            </Paths>
-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_LowerJejunum" name="PARAM_K_wat_cell_Lumen_LowerJejunum" dim="Dimensionless" formula="K_water_cell">
-            <Paths>
-              <Path path="536" as="200" />
-            </Paths>
-          </Formula>
-          <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_sto" name="PARAM_SA_int_cell_sto" dim="Area" formula="(V_sto * 1000 / 1.1)^0.75 * 1000 * 1E2">
-            <Paths>
-              <Path path="670" as="113" dim="51" />
-            </Paths>
-          </Formula>
-          <Formula id="Lumen_PKSim.PARAM_K_cell_pls_UpperIleum" name="PARAM_K_cell_pls_UpperIleum" dim="Dimensionless" formula="K_cell_pls">
-            <Paths>
-              <Path path="759" as="677" />
-            </Paths>
-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_UpperIleum" name="PARAM_K_wat_cell_Lumen_UpperIleum" dim="Dimensionless" formula="K_water_cell">
-            <Paths>
-              <Path path="540" as="200" />
-            </Paths>
-          </Formula>
-          <Formula id="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaBloodCells" name="PARAM_MassTransferIntestineToMucosaBloodCells" dim="Amount per time" formula="Q*HCT*C_bc">
-            <Paths>
-              <Path path="760" as="522" dim="220" />
-              <Path path="688" as="735" dim="690" />
-              <Path path="36" as="37" />
-            </Paths>
-          </Formula>
-          <Formula id="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaPlasma" name="PARAM_MassTransferIntestineToMucosaPlasma" dim="Amount per time" formula="Q*(1-HCT)*C_pls">
-            <Paths>
-              <Path path="760" as="522" dim="220" />
-              <Path path="688" as="689" dim="690" />
-              <Path path="36" as="37" />
-            </Paths>
-          </Formula>
-          <Formula id="Lumen_PKSim.PARAM_K_cell_pls_LowerIleum" name="PARAM_K_cell_pls_LowerIleum" dim="Dimensionless" formula="K_cell_pls">
-            <Paths>
-              <Path path="761" as="677" />
-            </Paths>
-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_LowerIleum" name="PARAM_K_wat_cell_Lumen_LowerIleum" dim="Dimensionless" formula="K_water_cell">
-            <Paths>
-              <Path path="544" as="200" />
-            </Paths>
-          </Formula>
-          <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_sin" name="PARAM_SA_int_cell_sin" dim="Area" formula="((V_sin-V_Mucosa) * 1000 / 11.1)^0.75 * 1000 * 1E2">
-            <Paths>
-              <Path path="670" as="105" dim="51" />
-              <Path path="762" as="506" dim="51" />
-            </Paths>
-          </Formula>
-          <Formula id="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int_sinlin" name="PARAM_SA_pls_int_sinlin" dim="Area" formula="k * f_vas_org * (V_org-V_Mucosa)">
-            <Paths>
-              <Path path="673" as="674" />
-              <Path path="670" as="191" dim="51" />
-              <Path path="763" as="506" dim="51" />
-              <Path path="675" as="316" dim="343" />
-            </Paths>
-          </Formula>
-          <Formula id="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls_sinlin" name="PARAM_SA_rbc_pls_sinlin" dim="Area" formula="HCT * A_to_V_bc * 0.6 * (V-V_Mucosa) * f_vas">
-            <Paths>
-              <Path path="673" as="168" />
-              <Path path="670" as="170" dim="51" />
-              <Path path="763" as="506" dim="51" />
-              <Path path="36" as="37" />
-              <Path path="671" as="672" dim="343" />
-            </Paths>
-          </Formula>
-          <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_lin" name="PARAM_SA_int_cell_lin" dim="Area" formula="((V_lin-V_Mucosa) * 1000 / 11.1)^0.75 * 1000 * 1E2">
-            <Paths>
-              <Path path="670" as="79" dim="51" />
-              <Path path="764" as="506" dim="51" />
-            </Paths>
-          </Formula>
-          <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_liv" name="PARAM_SA_int_cell_liv" dim="Area" formula="(V_liv * 1000 / 10)^0.75 * 82 * 1E2">
-            <Paths>
-              <Path path="670" as="83" dim="51" />
-            </Paths>
-          </Formula>
-          <Formula id="PlasmaClearance_PKSim.PARAM_min_PA_Q" name="PARAM_min_PA_Q" dim="Flow" formula="Min(PA_liv ;Q_liv + Q_pve)">
-            <Paths>
-              <Path path="765" as="766" dim="220" />
-              <Path path="691" as="631" dim="220" />
-              <Path path="767" as="768" dim="220" />
-            </Paths>
-          </Formula>
-          <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_lng" name="PARAM_SA_int_cell_lng" dim="Area" formula="(V_lng * 1000  / 2.2)^0.75 * 0.096 * 1E2">
-            <Paths>
-              <Path path="670" as="87" dim="51" />
-            </Paths>
-          </Formula>
-          <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mus" name="PARAM_SA_int_cell_mus" dim="Area" formula="(V_mus * 1000 / 110.1)^0.75 * 7.54 * 1E2">
-            <Paths>
-              <Path path="670" as="91" dim="51" />
-            </Paths>
-          </Formula>
-          <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_pan" name="PARAM_SA_int_cell_pan" dim="Area" formula="(V_pan * 1000 / 1.3)^0.75 * 1000 * 1E2">
-            <Paths>
-              <Path path="670" as="95" dim="51" />
-            </Paths>
-          </Formula>
-          <Formula id="Lumen_PKSim.PARAM_K_cell_pls_Rectum" name="PARAM_K_cell_pls_Rectum" dim="Dimensionless" formula="K_cell_pls">
-            <Paths>
-              <Path path="769" as="677" />
-            </Paths>
-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_Rectum" name="PARAM_K_wat_cell_Lumen_Rectum" dim="Dimensionless" formula="K_water_cell">
-            <Paths>
-              <Path path="611" as="200" />
-            </Paths>
-          </Formula>
-          <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_skn" name="PARAM_SA_int_cell_skn" dim="Area" formula="(V_skn * 1000 / 43.4)^0.75 * 0.12 * 1E2">
-            <Paths>
-              <Path path="670" as="101" dim="51" />
-            </Paths>
-          </Formula>
-          <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_spl" name="PARAM_SA_int_cell_spl" dim="Area" formula="(V_spl * 1000 / 1.3)^0.75 * 1000 * 1E2">
-            <Paths>
-              <Path path="670" as="109" dim="51" />
-            </Paths>
-          </Formula>
-          <Formula id="DistributionSaliva_PKSim.PARAM_K_cell_pls_slv" name="PARAM_K_cell_pls_slv" dim="Dimensionless" formula="R * fu">
-            <Paths>
-              <Path path="770" as="771" />
-              <Path path="29" as="30" dim="20" />
-            </Paths>
-          </Formula>
-          <Formula id="DistributionSaliva_PKSim.PARAM_SalivaPlasmaRatio" name="PARAM_SalivaPlasmaRatio" dim="Dimensionless" formula="1">
-            <Paths>
-              <Path path="282" as="283" />
-              <Path path="278" as="279" />
-              <Path path="272" as="273" />
-              <Path path="772" as="773" />
-              <Path path="774" as="775" />
-            </Paths>
-          </Formula>
-          <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mucosa_duo" name="PARAM_SA_int_cell_mucosa_duo" dim="Area" formula="Ageom * AeffFactor / MicrovilliFactor">
-            <Paths>
-              <Path path="776" as="696" />
-              <Path path="777" as="698" dim="187" />
-              <Path path="778" as="779" />
-            </Paths>
-          </Formula>
-          <Formula id="DiffusionCommon_PKSim.PARAM_P_int_cell_Mucosa" name="PARAM_P_int_cell_Mucosa" dim="Velocity" formula="P * P_int_cell_factor * P_int_scalefactor">
-            <Paths>
-              <Path path="678" as="679" />
-              <Path path="780" as="781" />
-              <Path path="9" as="10" dim="2" />
-            </Paths>
-          </Formula>
-          <Formula id="DiffusionCommon_PKSim.PARAM_P_cell_int_Mucosa" name="PARAM_P_cell_int_Mucosa" dim="Velocity" formula="P * P_cell_int_factor * P_int_scalefactor">
-            <Paths>
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-        </Formulas>
-        <StringMap>
-          <Map s="MOLECULE|Specific intestinal permeability (transcellular)" id="0" />
-          <Map s="P_int_InVitro" id="1" />
-          <Map s="Velocity" id="2" />
-          <Map s="..|Default Intestinal permeability (transcellular)" id="3" />
-          <Map s="P_int_trans_default" id="4" />
-          <Map s="..|Intestinal permeability (transcellular)" id="5" />
-          <Map s="P_int_trans" id="6" />
-          <Map s="MOLECULE|P_pls_bc_factor" id="7" />
-          <Map s="P_pls_rbc_factor" id="8" />
-          <Map s="MOLECULE|Permeability" id="9" />
-          <Map s="P" id="10" />
-          <Map s="MOLECULE|Calculated specific intestinal permeability (transcellular)" id="11" />
-          <Map s="MOLECULE|P_bc_pls_factor" id="12" />
-          <Map s="P_rbc_pls_factor" id="13" />
-          <Map s="..|BP_AGP" id="14" />
-          <Map s="Agp" id="15" />
-          <Map s="..|BP_ALBUMIN" id="16" />
-          <Map s="Albumin" id="17" />
-          <Map s="..|Fraction unbound (plasma, reference value)" id="18" />
-          <Map s="fu_ref" id="19" />
-          <Map s="Fraction" id="20" />
-          <Map s="..|Plasma protein binding partner" id="21" />
-          <Map s="BindingPartner" id="22" />
-          <Map s="Organism|Ontogeny factor (albumin)" id="23" />
-          <Map s="AlbuminOntgenyFactor" id="24" />
-          <Map s="Organism|Ontogeny factor (alpha1-acid glycoprotein)" id="25" />
-          <Map s="AgpOntogenyFactor" id="26" />
-          <Map s="Organism|Plasma protein scale factor" id="27" />
-          <Map s="PlasmaProteinScaleFactor" id="28" />
-          <Map s="MOLECULE|Fraction unbound (plasma)" id="29" />
-          <Map s="fu" id="30" />
-          <Map s="MOLECULE|Lipophilicity" id="31" />
-          <Map s="LogP" id="32" />
-          <Map s="Log Units" id="33" />
-          <Map s="MOLECULE|Partition coefficient (water/protein)" id="34" />
-          <Map s="KProt" id="35" />
-          <Map s="Organism|Hematocrit" id="36" />
-          <Map s="HCT" id="37" />
-          <Map s="Organism|Vf (lipid, blood cells)" id="38" />
-          <Map s="f_lipids_rbc" id="39" />
-          <Map s="Organism|Vf (protein,blood cells)" id="40" />
-          <Map s="f_proteins_rbc" id="41" />
-          <Map s="Organism|Vf (water,blood cells)" id="42" />
-          <Map s="f_water_rbc" id="43" />
-          <Map s="Organism|Rate constant for endosomal uptake (global)" id="44" />
-          <Map s="K_uptake" id="45" />
-          <Map s="Inversed time" id="46" />
-          <Map s="Organism|Rate constant for recycling from endosomal space (global)" id="47" />
-          <Map s="K_rec" id="48" />
-          <Map s="Organism|ArterialBlood|Volume" id="49" />
-          <Map s="V_art" id="50" />
-          <Map s="Volume" id="51" />
-          <Map s="Organism|Bone|Fraction vascular" id="52" />
-          <Map s="f_vas_bon" id="53" />
-          <Map s="Organism|Bone|Volume" id="54" />
-          <Map s="V_bon" id="55" />
-          <Map s="Organism|Brain|Fraction vascular" id="56" />
-          <Map s="f_vas_brn" id="57" />
-          <Map s="Organism|Brain|Volume" id="58" />
-          <Map s="V_brn" id="59" />
-          <Map s="Organism|Fat|Fraction vascular" id="60" />
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-          <Map s="Organism|Fat|Volume" id="62" />
-          <Map s="V_fat" id="63" />
-          <Map s="Organism|Gonads|Fraction vascular" id="64" />
-          <Map s="f_vas_tes" id="65" />
-          <Map s="Organism|Gonads|Volume" id="66" />
-          <Map s="V_tes" id="67" />
-          <Map s="Organism|Heart|Fraction vascular" id="68" />
-          <Map s="f_vas_hrt" id="69" />
-          <Map s="Organism|Heart|Volume" id="70" />
-          <Map s="V_hrt" id="71" />
-          <Map s="Organism|Kidney|Fraction vascular" id="72" />
-          <Map s="f_vas_kid" id="73" />
-          <Map s="Organism|Kidney|Volume" id="74" />
-          <Map s="V_kid" id="75" />
-          <Map s="Organism|LargeIntestine|Fraction vascular" id="76" />
-          <Map s="f_vas_lin" id="77" />
-          <Map s="Organism|LargeIntestine|Volume" id="78" />
-          <Map s="V_lin" id="79" />
-          <Map s="Organism|Liver|Fraction vascular" id="80" />
-          <Map s="f_vas_liv" id="81" />
-          <Map s="Organism|Liver|Volume" id="82" />
-          <Map s="V_liv" id="83" />
-          <Map s="Organism|Lung|Fraction vascular" id="84" />
-          <Map s="f_vas_lng" id="85" />
-          <Map s="Organism|Lung|Volume" id="86" />
-          <Map s="V_lng" id="87" />
-          <Map s="Organism|Muscle|Fraction vascular" id="88" />
-          <Map s="f_vas_mus" id="89" />
-          <Map s="Organism|Muscle|Volume" id="90" />
-          <Map s="V_mus" id="91" />
-          <Map s="Organism|Pancreas|Fraction vascular" id="92" />
-          <Map s="f_vas_pan" id="93" />
-          <Map s="Organism|Pancreas|Volume" id="94" />
-          <Map s="V_pan" id="95" />
-          <Map s="Organism|PortalVein|Volume" id="96" />
-          <Map s="V_pve" id="97" />
-          <Map s="Organism|Skin|Fraction vascular" id="98" />
-          <Map s="f_vas_skn" id="99" />
-          <Map s="Organism|Skin|Volume" id="100" />
-          <Map s="V_skn" id="101" />
-          <Map s="Organism|SmallIntestine|Fraction vascular" id="102" />
-          <Map s="f_vas_sin" id="103" />
-          <Map s="Organism|SmallIntestine|Volume" id="104" />
-          <Map s="V_sin" id="105" />
-          <Map s="Organism|Spleen|Fraction vascular" id="106" />
-          <Map s="f_vas_spl" id="107" />
-          <Map s="Organism|Spleen|Volume" id="108" />
-          <Map s="V_spl" id="109" />
-          <Map s="Organism|Stomach|Fraction vascular" id="110" />
-          <Map s="f_vas_sto" id="111" />
-          <Map s="Organism|Stomach|Volume" id="112" />
-          <Map s="V_sto" id="113" />
-          <Map s="Organism|VenousBlood|Volume" id="114" />
-          <Map s="V_ven" id="115" />
-          <Map s="Organism|ArterialBlood|Weight (tissue)" id="116" />
-          <Map s="M_art" id="117" />
-          <Map s="Mass" id="118" />
-          <Map s="Organism|Bone|Weight (tissue)" id="119" />
-          <Map s="M_bon" id="120" />
-          <Map s="Organism|Brain|Weight (tissue)" id="121" />
-          <Map s="M_brn" id="122" />
-          <Map s="Organism|Fat|Weight (tissue)" id="123" />
-          <Map s="M_fat" id="124" />
-          <Map s="Organism|Gonads|Weight (tissue)" id="125" />
-          <Map s="M_tes" id="126" />
-          <Map s="Organism|Heart|Weight (tissue)" id="127" />
-          <Map s="M_hrt" id="128" />
-          <Map s="Organism|Kidney|Weight (tissue)" id="129" />
-          <Map s="M_kid" id="130" />
-          <Map s="Organism|LargeIntestine|Weight (tissue)" id="131" />
-          <Map s="M_lin" id="132" />
-          <Map s="Organism|Liver|Weight (tissue)" id="133" />
-          <Map s="M_liv" id="134" />
-          <Map s="Organism|Lung|Weight (tissue)" id="135" />
-          <Map s="M_lng" id="136" />
-          <Map s="Organism|Muscle|Weight (tissue)" id="137" />
-          <Map s="M_mus" id="138" />
-          <Map s="Organism|Pancreas|Weight (tissue)" id="139" />
-          <Map s="M_pan" id="140" />
-          <Map s="Organism|PortalVein|Weight (tissue)" id="141" />
-          <Map s="M_pve" id="142" />
-          <Map s="Organism|Skin|Weight (tissue)" id="143" />
-          <Map s="M_skn" id="144" />
-          <Map s="Organism|SmallIntestine|Weight (tissue)" id="145" />
-          <Map s="M_sin" id="146" />
-          <Map s="Organism|Spleen|Weight (tissue)" id="147" />
-          <Map s="M_spl" id="148" />
-          <Map s="Organism|Stomach|Weight (tissue)" id="149" />
-          <Map s="M_sto" id="150" />
-          <Map s="Organism|VenousBlood|Weight (tissue)" id="151" />
-          <Map s="M_ven" id="152" />
-          <Map s="..|Age" id="153" />
-          <Map s="Age" id="154" />
-          <Map s="Age in years" id="155" />
-          <Map s="..|Gestational age" id="156" />
-          <Map s="GA" id="157" />
-          <Map s="Age in weeks" id="158" />
-          <Map s="Organism|Height" id="159" />
-          <Map s="Height" id="160" />
-          <Map s="Length" id="161" />
-          <Map s="Organism|Weight" id="162" />
-          <Map s="BW" id="163" />
-          <Map s="..|Density (tissue)" id="164" />
-          <Map s="Density" id="165" />
-          <Map s="..|Volume" id="166" />
-          <Map s="..|..|Fraction vascular" id="167" />
-          <Map s="f_vas" id="168" />
-          <Map s="..|..|Volume" id="169" />
-          <Map s="V" id="170" />
-          <Map s="MOLECULE|Ontogeny factor" id="171" />
-          <Map s="f_onto" id="172" />
-          <Map s="MOLECULE|Partition coefficient (blood cells/plasma)" id="173" />
-          <Map s="K_rbc" id="174" />
-          <Map s="..|Gallbladder ejection half-time" id="175" />
-          <Map s="EHC_HalfTime" id="176" />
-          <Map s="Time" id="177" />
-          <Map s="..|Specific blood flow rate" id="178" />
-          <Map s="Qspec" id="179" />
-          <Map s="Flow per weight organ" id="180" />
-          <Map s="..|Weight (tissue)" id="181" />
-          <Map s="Weight" id="182" />
-          <Map s="Organism|Thickness (endothelium)" id="183" />
-          <Map s="d_endo" id="184" />
-          <Map s="Neighborhoods|Bone_pls_Bone_int|Surface area (plasma/interstitial)" id="185" />
-          <Map s="SA_pls_int" id="186" />
-          <Map s="Area" id="187" />
-          <Map s="..|Fraction interstitial" id="188" />
-          <Map s="f_int" id="189" />
-          <Map s="..|Fraction vascular" id="190" />
-          <Map s="V_org" id="191" />
-          <Map s="..|..|Fraction interstitial" id="192" />
-          <Map s="Organism|pH (interstitial)" id="193" />
-          <Map s="pH_int" id="194" />
-          <Map s="Neighborhoods|Bone_int_Bone_cell|MOLECULE|Partition coefficient (interstitial/water)" id="195" />
-          <Map s="K_water_int" id="196" />
-          <Map s="..|..|Fraction intracellular" id="197" />
-          <Map s="f_cell" id="198" />
-          <Map s="Neighborhoods|Bone_int_Bone_cell|MOLECULE|Partition coefficient (intracellular/water)" id="199" />
-          <Map s="K_water_cell" id="200" />
-          <Map s="Neighborhoods|Brain_pls_Brain_int|Surface area (plasma/interstitial)" id="201" />
-          <Map s="Neighborhoods|Brain_int_Brain_cell|MOLECULE|Partition coefficient (interstitial/water)" id="202" />
-          <Map s="Neighborhoods|Brain_int_Brain_cell|MOLECULE|Partition coefficient (intracellular/water)" id="203" />
-          <Map s="Neighborhoods|Fat_pls_Fat_int|Surface area (plasma/interstitial)" id="204" />
-          <Map s="Neighborhoods|Fat_int_Fat_cell|MOLECULE|Partition coefficient (interstitial/water)" id="205" />
-          <Map s="Neighborhoods|Fat_int_Fat_cell|MOLECULE|Partition coefficient (intracellular/water)" id="206" />
-          <Map s="Neighborhoods|Gonads_pls_Gonads_int|Surface area (plasma/interstitial)" id="207" />
-          <Map s="Neighborhoods|Gonads_int_Gonads_cell|MOLECULE|Partition coefficient (interstitial/water)" id="208" />
-          <Map s="Neighborhoods|Gonads_int_Gonads_cell|MOLECULE|Partition coefficient (intracellular/water)" id="209" />
-          <Map s="Neighborhoods|Heart_pls_Heart_int|Surface area (plasma/interstitial)" id="210" />
-          <Map s="Neighborhoods|Heart_int_Heart_cell|MOLECULE|Partition coefficient (interstitial/water)" id="211" />
-          <Map s="Neighborhoods|Heart_int_Heart_cell|MOLECULE|Partition coefficient (intracellular/water)" id="212" />
-          <Map s="Neighborhoods|Kidney_pls_Kidney_int|Surface area (plasma/interstitial)" id="213" />
-          <Map s="Organism|Estimated gestational age" id="214" />
-          <Map s="PMA" id="215" />
-          <Map s="Organism|Kidney|fGFRpremat" id="216" />
-          <Map s="GFR_premat" id="217" />
-          <Map s="Organism|Kidney|GFRmat" id="218" />
-          <Map s="GFR_mat" id="219" />
-          <Map s="Flow" id="220" />
-          <Map s="Organism|Kidney|Hill coefficient for GFR" id="221" />
-          <Map s="Hill" id="222" />
-          <Map s="Organism|Kidney|TM50 for GFR" id="223" />
-          <Map s="TM50" id="224" />
-          <Map s="Organism|Kidney|Volume (standard kidney)" id="225" />
-          <Map s="V_kid_std" id="226" />
-          <Map s="Neighborhoods|Kidney_int_Kidney_cell|MOLECULE|Partition coefficient (interstitial/water)" id="227" />
-          <Map s="Neighborhoods|Kidney_int_Kidney_cell|MOLECULE|Partition coefficient (intracellular/water)" id="228" />
-          <Map s="..|Distal radius" id="229" />
-          <Map s="r2" id="230" />
-          <Map s="..|Length" id="231" />
-          <Map s="L" id="232" />
-          <Map s="..|Proximal radius" id="233" />
-          <Map s="r1" id="234" />
-          <Map s="..|Geometric surface area" id="235" />
-          <Map s="..|Thickness of gut wall" id="236" />
-          <Map s="d" id="237" />
-          <Map s="..|pH in fasted state" id="238" />
-          <Map s="pH_fasted" id="239" />
-          <Map s="..|Fractional steady state fill level" id="240" />
-          <Map s="SteadyStateFillLevel" id="241" />
-          <Map s="..|Inverse rate of inflow of liquid into stomach" id="242" />
-          <Map s="StomachInflowTime" id="243" />
-          <Map s="..|Fraction of geometric volume filled with liquid" id="244" />
-          <Map s="FillLevel" id="245" />
-          <Map s="..|Liquid" id="246" />
-          <Map s="Liquid" id="247" />
-          <Map s="..|Gastric emptying time" id="248" />
-          <Map s="GET" id="249" />
-          <Map s="..|FillLevelFlag" id="250" />
-          <Map s="FillLevelFlag" id="251" />
-          <Map s="..|Liquid transfer rate" id="252" />
-          <Map s="LT_sto" id="253" />
-          <Map s="..|Secretion of liquid" id="254" />
-          <Map s="Inflow" id="255" />
-          <Map s="..|..|OralApplicationsEnabled" id="256" />
-          <Map s="OralApplicationsEnabled" id="257" />
-          <Map s="..|Intestinal transit rate (absolute)" id="258" />
-          <Map s="w" id="259" />
-          <Map s="..|..|Duodenum|FillLevelFlag" id="260" />
-          <Map s="FillLevelFlagNext" id="261" />
-          <Map s="..|pKa_pH_WS_lum_F1" id="262" />
-          <Map s="F1" id="263" />
-          <Map s="..|pKa_pH_WS_lum_F2" id="264" />
-          <Map s="F2" id="265" />
-          <Map s="..|pKa_pH_WS_lum_F3" id="266" />
-          <Map s="F3" id="267" />
-          <Map s="MOLECULE|Compound type 2" id="268" />
-          <Map s="CT2" id="269" />
-          <Map s="MOLECULE|CT_NEUTRAL" id="270" />
-          <Map s="CT_NEUTRAL" id="271" />
-          <Map s="MOLECULE|pKa value 2" id="272" />
-          <Map s="pKa_2" id="273" />
-          <Map s="..|..|pH" id="274" />
-          <Map s="pH" id="275" />
-          <Map s="MOLECULE|Compound type 1" id="276" />
-          <Map s="CT1" id="277" />
-          <Map s="MOLECULE|pKa value 1" id="278" />
-          <Map s="pKa_1" id="279" />
-          <Map s="MOLECULE|Compound type 0" id="280" />
-          <Map s="CT0" id="281" />
-          <Map s="MOLECULE|pKa value 0" id="282" />
-          <Map s="pKa_0" id="283" />
-          <Map s="MOLECULE|Ontogeny factor GI" id="284" />
-          <Map s="..|pKa_pH_WS_lum_K1" id="285" />
-          <Map s="K1" id="286" />
-          <Map s="..|pKa_pH_WS_lum_K2" id="287" />
-          <Map s="K2" id="288" />
-          <Map s="..|pKa_pH_WS_lum_K3" id="289" />
-          <Map s="K3" id="290" />
-          <Map s="..|pKa_pH_WS_lum_K4" id="291" />
-          <Map s="K4" id="292" />
-          <Map s="..|pKa_pH_WS_lum_K5" id="293" />
-          <Map s="K5" id="294" />
-          <Map s="..|pKa_pH_WS_lum_K6" id="295" />
-          <Map s="K6" id="296" />
-          <Map s="..|pKa_pH_WS_lum_K7" id="297" />
-          <Map s="K7" id="298" />
-          <Map s="..|pKa_pH_WS_lum_K8" id="299" />
-          <Map s="K8" id="300" />
-          <Map s="MOLECULE|Solubility gain per charge" id="301" />
-          <Map s="base" id="302" />
-          <Map s="..|Solubility_pKa_pH_Factor" id="303" />
-          <Map s="Solubility_pKa_pH_Factor" id="304" />
-          <Map s="MOLECULE|Solubility at reference pH" id="305" />
-          <Map s="Solubility" id="306" />
-          <Map s="Concentration (mass)" id="307" />
-          <Map s="MOLECULE|Solubility_pKa_pH_Factor" id="308" />
-          <Map s="Solubility_pKa_REFpH_Factor" id="309" />
-          <Map s="..|..|..|Height" id="310" />
-          <Map s="..|r1_p0" id="311" />
-          <Map s="r1_p0" id="312" />
-          <Map s="..|r1_p1" id="313" />
-          <Map s="r1_p1" id="314" />
-          <Map s="alpha" id="315" />
-          <Map s="k" id="316" />
-          <Map s="inflow" id="317" />
-          <Map s="..|..|Stomach|Fractional steady state fill level" id="318" />
-          <Map s="alpha_p" id="319" />
-          <Map s="..|..|Stomach|Intestinal transit rate (absolute)" id="320" />
-          <Map s="k_p" id="321" />
-          <Map s="..|..|Stomach|Volume" id="322" />
-          <Map s="V_p" id="323" />
-          <Map s="..|r2_p0" id="324" />
-          <Map s="r2_p0" id="325" />
-          <Map s="..|r2_p1" id="326" />
-          <Map s="r2_p1" id="327" />
-          <Map s="..|Intestinal transit rate" id="328" />
-          <Map s="LuminalVelocity" id="329" />
-          <Map s="Organism|SmallIntestine|Small intestinal transit time factor" id="330" />
-          <Map s="SITT_fact" id="331" />
-          <Map s="..|L_p0" id="332" />
-          <Map s="L_p0" id="333" />
-          <Map s="..|L_p1" id="334" />
-          <Map s="L_p1" id="335" />
-          <Map s="..|..|UpperJejunum|FillLevelFlag" id="336" />
-          <Map s="..|Thickness_p1" id="337" />
-          <Map s="Thickness_p1" id="338" />
-          <Map s="..|Thickness_p2" id="339" />
-          <Map s="Thickness_p2" id="340" />
-          <Map s="..|Thickness_p3" id="341" />
-          <Map s="Thickness_p3" id="342" />
-          <Map s="Inversed length" id="343" />
-          <Map s="V_Intestine" id="344" />
-          <Map s="..|Absorption of liquid" id="345" />
-          <Map s="Outflow" id="346" />
-          <Map s="LT_duo" id="347" />
-          <Map s="..|..|Stomach|Liquid transfer rate" id="348" />
-          <Map s="Neighborhoods|Lumen_duo_Duodenum_pls|MOLECULE|Sum of active process rates" id="349" />
-          <Map s="ActiveRates_para" id="350" />
-          <Map s="Amount per time" id="351" />
-          <Map s="Neighborhoods|Lumen_duo_Duodenum_cell|MOLECULE|Sum of active process rates" id="352" />
-          <Map s="ActiveRates_trans" id="353" />
-          <Map s="Neighborhoods|Lumen_duo_Duodenum_pls|MOLECULE|Sum of passive process rates" id="354" />
-          <Map s="PassiveRates_para" id="355" />
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-          <Map s="PassiveRates_trans" id="357" />
-          <Map s="..|..|LowerJejunum|FillLevelFlag" id="358" />
-          <Map s="LT_uje" id="359" />
-          <Map s="..|..|Duodenum|Liquid transfer rate" id="360" />
-          <Map s="..|..|Duodenum|Fractional steady state fill level" id="361" />
-          <Map s="..|..|Duodenum|Intestinal transit rate (absolute)" id="362" />
-          <Map s="..|..|Duodenum|Volume" id="363" />
-          <Map s="Neighborhoods|Lumen_uje_UpperJejunum_pls|MOLECULE|Sum of active process rates" id="364" />
-          <Map s="Neighborhoods|Lumen_uje_UpperJejunum_cell|MOLECULE|Sum of active process rates" id="365" />
-          <Map s="Neighborhoods|Lumen_uje_UpperJejunum_pls|MOLECULE|Sum of passive process rates" id="366" />
-          <Map s="Neighborhoods|Lumen_uje_UpperJejunum_cell|MOLECULE|Sum of passive process rates" id="367" />
-          <Map s="..|..|UpperJejunum|Fractional steady state fill level" id="368" />
-          <Map s="..|..|UpperJejunum|Intestinal transit rate (absolute)" id="369" />
-          <Map s="..|..|UpperJejunum|Volume" id="370" />
-          <Map s="LT_lje" id="371" />
-          <Map s="..|..|UpperJejunum|Liquid transfer rate" id="372" />
-          <Map s="..|..|UpperIleum|FillLevelFlag" id="373" />
-          <Map s="Neighborhoods|Lumen_lje_LowerJejunum_pls|MOLECULE|Sum of active process rates" id="374" />
-          <Map s="Neighborhoods|Lumen_lje_LowerJejunum_cell|MOLECULE|Sum of active process rates" id="375" />
-          <Map s="Neighborhoods|Lumen_lje_LowerJejunum_pls|MOLECULE|Sum of passive process rates" id="376" />
-          <Map s="Neighborhoods|Lumen_lje_LowerJejunum_cell|MOLECULE|Sum of passive process rates" id="377" />
-          <Map s="..|..|LowerJejunum|Fractional steady state fill level" id="378" />
-          <Map s="..|..|LowerJejunum|Intestinal transit rate (absolute)" id="379" />
-          <Map s="..|..|LowerJejunum|Volume" id="380" />
-          <Map s="LT_uil" id="381" />
-          <Map s="..|..|LowerJejunum|Liquid transfer rate" id="382" />
-          <Map s="..|..|LowerIleum|FillLevelFlag" id="383" />
-          <Map s="Neighborhoods|Lumen_uil_UpperIleum_pls|MOLECULE|Sum of active process rates" id="384" />
-          <Map s="Neighborhoods|Lumen_uil_UpperIleum_cell|MOLECULE|Sum of active process rates" id="385" />
-          <Map s="Neighborhoods|Lumen_uil_UpperIleum_pls|MOLECULE|Sum of passive process rates" id="386" />
-          <Map s="Neighborhoods|Lumen_uil_UpperIleum_cell|MOLECULE|Sum of passive process rates" id="387" />
-          <Map s="..|..|UpperIleum|Fractional steady state fill level" id="388" />
-          <Map s="..|..|UpperIleum|Intestinal transit rate (absolute)" id="389" />
-          <Map s="..|..|UpperIleum|Volume" id="390" />
-          <Map s="LT_lil" id="391" />
-          <Map s="..|..|UpperIleum|Liquid transfer rate" id="392" />
-          <Map s="..|..|Caecum|FillLevelFlag" id="393" />
-          <Map s="Neighborhoods|Lumen_lil_LowerIleum_pls|MOLECULE|Sum of active process rates" id="394" />
-          <Map s="Neighborhoods|Lumen_lil_LowerIleum_cell|MOLECULE|Sum of active process rates" id="395" />
-          <Map s="Neighborhoods|Lumen_lil_LowerIleum_pls|MOLECULE|Sum of passive process rates" id="396" />
-          <Map s="Neighborhoods|Lumen_lil_LowerIleum_cell|MOLECULE|Sum of passive process rates" id="397" />
-          <Map s="..|..|LowerIleum|Fractional steady state fill level" id="398" />
-          <Map s="..|..|LowerIleum|Intestinal transit rate (absolute)" id="399" />
-          <Map s="..|..|LowerIleum|Volume" id="400" />
-          <Map s="Organism|LargeIntestine|Large intestinal transit time factor" id="401" />
-          <Map s="LITT_fact" id="402" />
-          <Map s="LT_cae" id="403" />
-          <Map s="..|..|LowerIleum|Liquid transfer rate" id="404" />
-          <Map s="..|..|ColonAscendens|FillLevelFlag" id="405" />
-          <Map s="Neighborhoods|Lumen_cae_Caecum_pls|MOLECULE|Sum of active process rates" id="406" />
-          <Map s="Neighborhoods|Lumen_cae_Caecum_cell|MOLECULE|Sum of active process rates" id="407" />
-          <Map s="Neighborhoods|Lumen_cae_Caecum_pls|MOLECULE|Sum of passive process rates" id="408" />
-          <Map s="Neighborhoods|Lumen_cae_Caecum_cell|MOLECULE|Sum of passive process rates" id="409" />
-          <Map s="..|..|Caecum|Fractional steady state fill level" id="410" />
-          <Map s="..|..|Caecum|Intestinal transit rate (absolute)" id="411" />
-          <Map s="..|..|Caecum|Volume" id="412" />
-          <Map s="LT_colasc" id="413" />
-          <Map s="..|..|Caecum|Liquid transfer rate" id="414" />
-          <Map s="..|..|ColonTransversum|FillLevelFlag" id="415" />
-          <Map s="Neighborhoods|Lumen_colasc_ColonAscendens_pls|MOLECULE|Sum of active process rates" id="416" />
-          <Map s="Neighborhoods|Lumen_colasc_ColonAscendens_cell|MOLECULE|Sum of active process rates" id="417" />
-          <Map s="Neighborhoods|Lumen_colasc_ColonAscendens_pls|MOLECULE|Sum of passive process rates" id="418" />
-          <Map s="Neighborhoods|Lumen_colasc_ColonAscendens_cell|MOLECULE|Sum of passive process rates" id="419" />
-          <Map s="..|..|ColonDescendens|FillLevelFlag" id="420" />
-          <Map s="LT_coltrans" id="421" />
-          <Map s="..|..|ColonAscendens|Liquid transfer rate" id="422" />
-          <Map s="..|..|ColonAscendens|Fractional steady state fill level" id="423" />
-          <Map s="..|..|ColonAscendens|Intestinal transit rate (absolute)" id="424" />
-          <Map s="..|..|ColonAscendens|Volume" id="425" />
-          <Map s="Neighborhoods|Lumen_coltrans_ColonTransversum_pls|MOLECULE|Sum of active process rates" id="426" />
-          <Map s="Neighborhoods|Lumen_coltrans_ColonTransversum_cell|MOLECULE|Sum of active process rates" id="427" />
-          <Map s="Neighborhoods|Lumen_coltrans_ColonTransversum_pls|MOLECULE|Sum of passive process rates" id="428" />
-          <Map s="Neighborhoods|Lumen_coltrans_ColonTransversum_cell|MOLECULE|Sum of passive process rates" id="429" />
-          <Map s="LT_coldesc" id="430" />
-          <Map s="..|..|ColonTransversum|Liquid transfer rate" id="431" />
-          <Map s="..|..|ColonSigmoid|FillLevelFlag" id="432" />
-          <Map s="..|..|ColonTransversum|Fractional steady state fill level" id="433" />
-          <Map s="..|..|ColonTransversum|Intestinal transit rate (absolute)" id="434" />
-          <Map s="..|..|ColonTransversum|Volume" id="435" />
-          <Map s="Neighborhoods|Lumen_coldesc_ColonDescendens_pls|MOLECULE|Sum of active process rates" id="436" />
-          <Map s="Neighborhoods|Lumen_coldesc_ColonDescendens_cell|MOLECULE|Sum of active process rates" id="437" />
-          <Map s="Neighborhoods|Lumen_coldesc_ColonDescendens_pls|MOLECULE|Sum of passive process rates" id="438" />
-          <Map s="Neighborhoods|Lumen_coldesc_ColonDescendens_cell|MOLECULE|Sum of passive process rates" id="439" />
-          <Map s="..|..|ColonDescendens|Fractional steady state fill level" id="440" />
-          <Map s="..|..|ColonDescendens|Intestinal transit rate (absolute)" id="441" />
-          <Map s="..|..|ColonDescendens|Volume" id="442" />
-          <Map s="LT_colsigm" id="443" />
-          <Map s="..|..|ColonDescendens|Liquid transfer rate" id="444" />
-          <Map s="..|..|Rectum|FillLevelFlag" id="445" />
-          <Map s="Neighborhoods|Lumen_colsigm_ColonSigmoid_pls|MOLECULE|Sum of active process rates" id="446" />
-          <Map s="Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|MOLECULE|Sum of active process rates" id="447" />
-          <Map s="Neighborhoods|Lumen_colsigm_ColonSigmoid_pls|MOLECULE|Sum of passive process rates" id="448" />
-          <Map s="Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|MOLECULE|Sum of passive process rates" id="449" />
-          <Map s="..|..|ColonSigmoid|Fractional steady state fill level" id="450" />
-          <Map s="..|..|ColonSigmoid|Intestinal transit rate (absolute)" id="451" />
-          <Map s="..|..|ColonSigmoid|Volume" id="452" />
-          <Map s="LT_rect" id="453" />
-          <Map s="..|..|ColonSigmoid|Liquid transfer rate" id="454" />
-          <Map s="Neighborhoods|Lumen_rect_Rectum_pls|MOLECULE|Sum of active process rates" id="455" />
-          <Map s="Neighborhoods|Lumen_rect_Rectum_cell|MOLECULE|Sum of active process rates" id="456" />
-          <Map s="Neighborhoods|Lumen_rect_Rectum_pls|MOLECULE|Sum of passive process rates" id="457" />
-          <Map s="Neighborhoods|Lumen_rect_Rectum_cell|MOLECULE|Sum of passive process rates" id="458" />
-          <Map s="..|..|Rectum|Liquid transfer rate" id="459" />
-          <Map s="LT_rec" id="460" />
-          <Map s="Neighborhoods|Stomach_pls_Stomach_int|Surface area (plasma/interstitial)" id="461" />
-          <Map s="Neighborhoods|Stomach_int_Stomach_cell|MOLECULE|Partition coefficient (interstitial/water)" id="462" />
-          <Map s="Neighborhoods|Stomach_int_Stomach_cell|MOLECULE|Partition coefficient (intracellular/water)" id="463" />
-          <Map s="..|Small intestinal transit time" id="464" />
-          <Map s="SITT" id="465" />
-          <Map s="..|Small intestinal transit time factor intercept" id="466" />
-          <Map s="P2" id="467" />
-          <Map s="..|Small intestinal transit time factor slope" id="468" />
-          <Map s="P1" id="469" />
-          <Map s="..|Lymph flow rate (incl. mucosa)" id="470" />
-          <Map s="Q_lymph_incl_Mucosa" id="471" />
-          <Map s="..|Mucosa|Duodenum|Lymph flow rate" id="472" />
-          <Map s="Q_lymph_duo" id="473" />
-          <Map s="..|Mucosa|LowerIleum|Lymph flow rate" id="474" />
-          <Map s="Q_lymph_lil" id="475" />
-          <Map s="..|Mucosa|LowerJejunum|Lymph flow rate" id="476" />
-          <Map s="Q_lymph_lje" id="477" />
-          <Map s="..|Mucosa|UpperIleum|Lymph flow rate" id="478" />
-          <Map s="Q_lymph_uil" id="479" />
-          <Map s="..|Mucosa|UpperJejunum|Lymph flow rate" id="480" />
-          <Map s="Q_lymph_uje" id="481" />
-          <Map s="Neighborhoods|SmallIntestine_pls_SmallIntestine_int|Surface area (plasma/interstitial)" id="482" />
-          <Map s="..|Fluid recirculation flow rate (incl. mucosa)" id="483" />
-          <Map s="J_iso_incl_Mucosa" id="484" />
-          <Map s="..|Mucosa|Duodenum|Fluid recirculation flow rate" id="485" />
-          <Map s="J_iso_duo" id="486" />
-          <Map s="..|Mucosa|LowerIleum|Fluid recirculation flow rate" id="487" />
-          <Map s="J_iso_lil" id="488" />
-          <Map s="..|Mucosa|LowerJejunum|Fluid recirculation flow rate" id="489" />
-          <Map s="J_iso_lje" id="490" />
-          <Map s="..|Mucosa|UpperIleum|Fluid recirculation flow rate" id="491" />
-          <Map s="J_iso_uil" id="492" />
-          <Map s="..|Mucosa|UpperJejunum|Fluid recirculation flow rate" id="493" />
-          <Map s="J_iso_uje" id="494" />
-          <Map s="..|Mucosa|Duodenum|Volume" id="495" />
-          <Map s="V_duo" id="496" />
-          <Map s="..|Mucosa|LowerIleum|Volume" id="497" />
-          <Map s="V_lil" id="498" />
-          <Map s="..|Mucosa|LowerJejunum|Volume" id="499" />
-          <Map s="V_lje" id="500" />
-          <Map s="..|Mucosa|UpperIleum|Volume" id="501" />
-          <Map s="V_uil" id="502" />
-          <Map s="..|Mucosa|UpperJejunum|Volume" id="503" />
-          <Map s="V_uje" id="504" />
-          <Map s="..|..|Volume (mucosa)" id="505" />
-          <Map s="V_Mucosa" id="506" />
-          <Map s="Neighborhoods|SmallIntestine_int_SmallIntestine_cell|MOLECULE|Partition coefficient (interstitial/water)" id="507" />
-          <Map s="Neighborhoods|SmallIntestine_int_SmallIntestine_cell|MOLECULE|Partition coefficient (intracellular/water)" id="508" />
-          <Map s="..|Fraction mucosa" id="509" />
-          <Map s="fractionMucosa" id="510" />
-          <Map s="..|..|..|..|Lumen|Duodenum|Volume (gut wall)" id="511" />
-          <Map s="V_GutWall" id="512" />
-          <Map s="Neighborhoods|Duodenum_pls_Duodenum_int|Surface area (plasma/interstitial)" id="513" />
-          <Map s="..|..|..|Lymph flow rate (incl. mucosa)" id="514" />
-          <Map s="Q_lymph_intestine" id="515" />
-          <Map s="..|..|..|Volume" id="516" />
-          <Map s="V_intestine" id="517" />
-          <Map s="V_seg" id="518" />
-          <Map s="..|..|..|Fluid recirculation flow rate (incl. mucosa)" id="519" />
-          <Map s="J_iso_intestine" id="520" />
-          <Map s="..|..|..|Blood flow rate" id="521" />
-          <Map s="Q" id="522" />
-          <Map s="..|Fraction of regional blood flow rate" id="523" />
-          <Map s="regionalFractQ" id="524" />
-          <Map s="..|..|..|Mucosa blood flow fraction" id="525" />
-          <Map s="fractQ" id="526" />
-          <Map s="Neighborhoods|Duodenum_int_Duodenum_cell|MOLECULE|Partition coefficient (interstitial/water)" id="527" />
-          <Map s="Neighborhoods|Duodenum_int_Duodenum_cell|MOLECULE|Partition coefficient (intracellular/water)" id="528" />
-          <Map s="..|..|..|..|Lumen|UpperJejunum|Volume (gut wall)" id="529" />
-          <Map s="Neighborhoods|UpperJejunum_pls_UpperJejunum_int|Surface area (plasma/interstitial)" id="530" />
-          <Map s="Neighborhoods|UpperJejunum_int_UpperJejunum_cell|MOLECULE|Partition coefficient (interstitial/water)" id="531" />
-          <Map s="Neighborhoods|UpperJejunum_int_UpperJejunum_cell|MOLECULE|Partition coefficient (intracellular/water)" id="532" />
-          <Map s="..|..|..|..|Lumen|LowerJejunum|Volume (gut wall)" id="533" />
-          <Map s="Neighborhoods|LowerJejunum_pls_LowerJejunum_int|Surface area (plasma/interstitial)" id="534" />
-          <Map s="Neighborhoods|LowerJejunum_int_LowerJejunum_cell|MOLECULE|Partition coefficient (interstitial/water)" id="535" />
-          <Map s="Neighborhoods|LowerJejunum_int_LowerJejunum_cell|MOLECULE|Partition coefficient (intracellular/water)" id="536" />
-          <Map s="..|..|..|..|Lumen|UpperIleum|Volume (gut wall)" id="537" />
-          <Map s="Neighborhoods|UpperIleum_pls_UpperIleum_int|Surface area (plasma/interstitial)" id="538" />
-          <Map s="Neighborhoods|UpperIleum_int_UpperIleum_cell|MOLECULE|Partition coefficient (interstitial/water)" id="539" />
-          <Map s="Neighborhoods|UpperIleum_int_UpperIleum_cell|MOLECULE|Partition coefficient (intracellular/water)" id="540" />
-          <Map s="..|..|..|..|Lumen|LowerIleum|Volume (gut wall)" id="541" />
-          <Map s="Neighborhoods|LowerIleum_pls_LowerIleum_int|Surface area (plasma/interstitial)" id="542" />
-          <Map s="Neighborhoods|LowerIleum_int_LowerIleum_cell|MOLECULE|Partition coefficient (interstitial/water)" id="543" />
-          <Map s="Neighborhoods|LowerIleum_int_LowerIleum_cell|MOLECULE|Partition coefficient (intracellular/water)" id="544" />
-          <Map s="..|Mucosa|Caecum|Volume" id="545" />
-          <Map s="V_cae" id="546" />
-          <Map s="..|Mucosa|ColonAscendens|Volume" id="547" />
-          <Map s="V_ca" id="548" />
-          <Map s="..|Mucosa|ColonDescendens|Volume" id="549" />
-          <Map s="V_cd" id="550" />
-          <Map s="..|Mucosa|ColonSigmoid|Volume" id="551" />
-          <Map s="V_cs" id="552" />
-          <Map s="..|Mucosa|ColonTransversum|Volume" id="553" />
-          <Map s="V_ct" id="554" />
-          <Map s="..|Mucosa|Rectum|Volume" id="555" />
-          <Map s="V_rec" id="556" />
-          <Map s="..|Large intestinal transit time" id="557" />
-          <Map s="LITT" id="558" />
-          <Map s="..|Large intestinal transit time factor intercept" id="559" />
-          <Map s="..|Large intestinal transit time factor slope" id="560" />
-          <Map s="..|Mucosa|Caecum|Fluid recirculation flow rate" id="561" />
-          <Map s="J_iso_cae" id="562" />
-          <Map s="..|Mucosa|ColonAscendens|Fluid recirculation flow rate" id="563" />
-          <Map s="J_iso_colasc" id="564" />
-          <Map s="..|Mucosa|ColonDescendens|Fluid recirculation flow rate" id="565" />
-          <Map s="J_iso_coldesc" id="566" />
-          <Map s="..|Mucosa|ColonSigmoid|Fluid recirculation flow rate" id="567" />
-          <Map s="J_iso_colsigm" id="568" />
-          <Map s="..|Mucosa|ColonTransversum|Fluid recirculation flow rate" id="569" />
-          <Map s="J_iso_coltrans" id="570" />
-          <Map s="..|Mucosa|Rectum|Fluid recirculation flow rate" id="571" />
-          <Map s="J_iso_rect" id="572" />
-          <Map s="..|Mucosa|Caecum|Lymph flow rate" id="573" />
-          <Map s="Q_lymph_cae" id="574" />
-          <Map s="..|Mucosa|ColonAscendens|Lymph flow rate" id="575" />
-          <Map s="Q_lymph_colasc" id="576" />
-          <Map s="..|Mucosa|ColonDescendens|Lymph flow rate" id="577" />
-          <Map s="Q_lymph_coldesc" id="578" />
-          <Map s="..|Mucosa|ColonSigmoid|Lymph flow rate" id="579" />
-          <Map s="Q_lymph_colsigm" id="580" />
-          <Map s="..|Mucosa|ColonTransversum|Lymph flow rate" id="581" />
-          <Map s="Q_lymph_coltrans" id="582" />
-          <Map s="..|Mucosa|Rectum|Lymph flow rate" id="583" />
-          <Map s="Q_lymph_rect" id="584" />
-          <Map s="Neighborhoods|LargeIntestine_pls_LargeIntestine_int|Surface area (plasma/interstitial)" id="585" />
-          <Map s="Neighborhoods|LargeIntestine_int_LargeIntestine_cell|MOLECULE|Partition coefficient (interstitial/water)" id="586" />
-          <Map s="Neighborhoods|LargeIntestine_int_LargeIntestine_cell|MOLECULE|Partition coefficient (intracellular/water)" id="587" />
-          <Map s="..|..|..|..|Lumen|Caecum|Volume (gut wall)" id="588" />
-          <Map s="Neighborhoods|Caecum_pls_Caecum_int|Surface area (plasma/interstitial)" id="589" />
-          <Map s="Neighborhoods|Caecum_int_Caecum_cell|MOLECULE|Partition coefficient (interstitial/water)" id="590" />
-          <Map s="Neighborhoods|Caecum_int_Caecum_cell|MOLECULE|Partition coefficient (intracellular/water)" id="591" />
-          <Map s="..|..|..|..|Lumen|ColonAscendens|Volume (gut wall)" id="592" />
-          <Map s="Neighborhoods|ColonAscendens_pls_ColonAscendens_int|Surface area (plasma/interstitial)" id="593" />
-          <Map s="Neighborhoods|ColonAscendens_int_ColonAscendens_cell|MOLECULE|Partition coefficient (interstitial/water)" id="594" />
-          <Map s="Neighborhoods|ColonAscendens_int_ColonAscendens_cell|MOLECULE|Partition coefficient (intracellular/water)" id="595" />
-          <Map s="..|..|..|..|Lumen|ColonTransversum|Volume (gut wall)" id="596" />
-          <Map s="Neighborhoods|ColonTransversum_pls_ColonTransversum_int|Surface area (plasma/interstitial)" id="597" />
-          <Map s="Neighborhoods|ColonTransversum_int_ColonTransversum_cell|MOLECULE|Partition coefficient (interstitial/water)" id="598" />
-          <Map s="Neighborhoods|ColonTransversum_int_ColonTransversum_cell|MOLECULE|Partition coefficient (intracellular/water)" id="599" />
-          <Map s="..|..|..|..|Lumen|ColonDescendens|Volume (gut wall)" id="600" />
-          <Map s="Neighborhoods|ColonDescendens_pls_ColonDescendens_int|Surface area (plasma/interstitial)" id="601" />
-          <Map s="Neighborhoods|ColonDescendens_int_ColonDescendens_cell|MOLECULE|Partition coefficient (interstitial/water)" id="602" />
-          <Map s="Neighborhoods|ColonDescendens_int_ColonDescendens_cell|MOLECULE|Partition coefficient (intracellular/water)" id="603" />
-          <Map s="..|..|..|..|Lumen|ColonSigmoid|Volume (gut wall)" id="604" />
-          <Map s="Neighborhoods|ColonSigmoid_pls_ColonSigmoid_int|Surface area (plasma/interstitial)" id="605" />
-          <Map s="Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|MOLECULE|Partition coefficient (interstitial/water)" id="606" />
-          <Map s="Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|MOLECULE|Partition coefficient (intracellular/water)" id="607" />
-          <Map s="..|..|..|..|Lumen|Rectum|Volume (gut wall)" id="608" />
-          <Map s="Neighborhoods|Rectum_pls_Rectum_int|Surface area (plasma/interstitial)" id="609" />
-          <Map s="Neighborhoods|Rectum_int_Rectum_cell|MOLECULE|Partition coefficient (interstitial/water)" id="610" />
-          <Map s="Neighborhoods|Rectum_int_Rectum_cell|MOLECULE|Partition coefficient (intracellular/water)" id="611" />
-          <Map s="Neighborhoods|Liver_pls_Liver_int|Surface area (plasma/interstitial)" id="612" />
-          <Map s="Neighborhoods|Liver_int_Liver_cell|MOLECULE|Partition coefficient (interstitial/water)" id="613" />
-          <Map s="Neighborhoods|Liver_int_Liver_cell|MOLECULE|Partition coefficient (intracellular/water)" id="614" />
-          <Map s="Neighborhoods|Lung_pls_Lung_int|Surface area (plasma/interstitial)" id="615" />
-          <Map s="Organism|Bone|Blood flow rate" id="616" />
-          <Map s="Q_bon" id="617" />
-          <Map s="Organism|Brain|Blood flow rate" id="618" />
-          <Map s="Q_brn" id="619" />
-          <Map s="Organism|Fat|Blood flow rate" id="620" />
-          <Map s="Q_fat" id="621" />
-          <Map s="Organism|Gonads|Blood flow rate" id="622" />
-          <Map s="Q_tes" id="623" />
-          <Map s="Organism|Heart|Blood flow rate" id="624" />
-          <Map s="Q_hrt" id="625" />
-          <Map s="Organism|Kidney|Blood flow rate" id="626" />
-          <Map s="Q_kid" id="627" />
-          <Map s="Organism|LargeIntestine|Blood flow rate" id="628" />
-          <Map s="Q_lin" id="629" />
-          <Map s="Organism|Liver|Blood flow rate" id="630" />
-          <Map s="Q_liv" id="631" />
-          <Map s="Organism|Muscle|Blood flow rate" id="632" />
-          <Map s="Q_mus" id="633" />
-          <Map s="Organism|Pancreas|Blood flow rate" id="634" />
-          <Map s="Q_pan" id="635" />
-          <Map s="Organism|Skin|Blood flow rate" id="636" />
-          <Map s="Q_skn" id="637" />
-          <Map s="Organism|SmallIntestine|Blood flow rate" id="638" />
-          <Map s="Q_sin" id="639" />
-          <Map s="Organism|Spleen|Blood flow rate" id="640" />
-          <Map s="Q_spl" id="641" />
-          <Map s="Organism|Stomach|Blood flow rate" id="642" />
-          <Map s="Q_sto" id="643" />
-          <Map s="Neighborhoods|Lung_int_Lung_cell|MOLECULE|Partition coefficient (interstitial/water)" id="644" />
-          <Map s="Neighborhoods|Lung_int_Lung_cell|MOLECULE|Partition coefficient (intracellular/water)" id="645" />
-          <Map s="Neighborhoods|Muscle_pls_Muscle_int|Surface area (plasma/interstitial)" id="646" />
-          <Map s="Neighborhoods|Muscle_int_Muscle_cell|MOLECULE|Partition coefficient (interstitial/water)" id="647" />
-          <Map s="Neighborhoods|Muscle_int_Muscle_cell|MOLECULE|Partition coefficient (intracellular/water)" id="648" />
-          <Map s="Neighborhoods|Pancreas_pls_Pancreas_int|Surface area (plasma/interstitial)" id="649" />
-          <Map s="Neighborhoods|Pancreas_int_Pancreas_cell|MOLECULE|Partition coefficient (interstitial/water)" id="650" />
-          <Map s="Neighborhoods|Pancreas_int_Pancreas_cell|MOLECULE|Partition coefficient (intracellular/water)" id="651" />
-          <Map s="Organism|LargeIntestine|Lymph flow rate (incl. mucosa)" id="652" />
-          <Map s="Q_Lymph_lin_incl_Mucosa" id="653" />
-          <Map s="Organism|Pancreas|Lymph flow rate" id="654" />
-          <Map s="Q_Lymph_pan" id="655" />
-          <Map s="Organism|SmallIntestine|Lymph flow rate (incl. mucosa)" id="656" />
-          <Map s="Q_Lymph_sin_incl_Mucosa" id="657" />
-          <Map s="Organism|Spleen|Lymph flow rate" id="658" />
-          <Map s="Q_Lymph_spl" id="659" />
-          <Map s="Organism|Stomach|Lymph flow rate" id="660" />
-          <Map s="Q_Lymph_sto" id="661" />
-          <Map s="Neighborhoods|Skin_pls_Skin_int|Surface area (plasma/interstitial)" id="662" />
-          <Map s="Neighborhoods|Skin_int_Skin_cell|MOLECULE|Partition coefficient (interstitial/water)" id="663" />
-          <Map s="Neighborhoods|Skin_int_Skin_cell|MOLECULE|Partition coefficient (intracellular/water)" id="664" />
-          <Map s="Neighborhoods|Spleen_pls_Spleen_int|Surface area (plasma/interstitial)" id="665" />
-          <Map s="Neighborhoods|Spleen_int_Spleen_cell|MOLECULE|Partition coefficient (interstitial/water)" id="666" />
-          <Map s="Neighborhoods|Spleen_int_Spleen_cell|MOLECULE|Partition coefficient (intracellular/water)" id="667" />
-          <Map s="Organism|Saliva|Volume" id="668" />
-          <Map s="V_slv" id="669" />
-          <Map s="FIRST_NEIGHBOR|..|Volume" id="670" />
-          <Map s="Organism|Surface/Volume ratio (blood cells)" id="671" />
-          <Map s="A_to_V_bc" id="672" />
-          <Map s="FIRST_NEIGHBOR|..|Fraction vascular" id="673" />
-          <Map s="f_vas_org" id="674" />
-          <Map s="Organism|SA proportionality factor" id="675" />
-          <Map s="..|Partition coefficient (intracellular/plasma)" id="676" />
-          <Map s="K_cell_pls" id="677" />
-          <Map s="..|P_int_cell_factor" id="678" />
-          <Map s="P_int_cell_factor" id="679" />
-          <Map s="..|P_cell_int_factor" id="680" />
-          <Map s="P_cell_int_factor" id="681" />
-          <Map s="..|P (interstitial-&gt;intracellular)" id="682" />
-          <Map s="P_int_cell" id="683" />
-          <Map s="..|..|Surface area (interstitial/intracellular)" id="684" />
-          <Map s="SA" id="685" />
-          <Map s="..|P (intracellular-&gt;interstitial)" id="686" />
-          <Map s="P_cell_int" id="687" />
-          <Map s="FIRST_NEIGHBOR|MOLECULE|Concentration" id="688" />
-          <Map s="C_pls" id="689" />
-          <Map s="Concentration (molar)" id="690" />
-          <Map s="FIRST_NEIGHBOR|..|Blood flow rate" id="691" />
-          <Map s="..|pKa_pH_WS_cell_F1" id="692" />
-          <Map s="..|pKa_pH_WS_cell_F2" id="693" />
-          <Map s="..|pKa_pH_WS_cell_F3" id="694" />
-          <Map s="FIRST_NEIGHBOR|Effective surface area enhancement factor" id="695" />
-          <Map s="AeffFactor" id="696" />
-          <Map s="FIRST_NEIGHBOR|Geometric surface area" id="697" />
-          <Map s="Ageom" id="698" />
-          <Map s="FIRST_NEIGHBOR|Liquid" id="699" />
-          <Map s="FIRST_NEIGHBOR|MOLECULE" id="700" />
-          <Map s="DrugLiquid" id="701" />
-          <Map s="Amount" id="702" />
-          <Map s="SECOND_NEIGHBOR|MOLECULE|Concentration" id="703" />
-          <Map s="DrugMucosa" id="704" />
-          <Map s="MOLECULE|Intestinal permeability (transcellular)" id="705" />
-          <Map s="MOLECULE|Molecular weight" id="706" />
-          <Map s="MW" id="707" />
-          <Map s="Molecular weight" id="708" />
-          <Map s="NEIGHBORHOOD|MOLECULE|P_int_trans_cell_lum_factor" id="709" />
-          <Map s="P_int_trans_cell_lum_factor" id="710" />
-          <Map s="NEIGHBORHOOD|MOLECULE|P_int_trans_lum_cell_factor" id="711" />
-          <Map s="P_int_trans_lum_cell_factor" id="712" />
-          <Map s="FIRST_NEIGHBOR|MOLECULE|Solubility" id="713" />
-          <Map s="FIRST_NEIGHBOR|..|OralApplicationsEnabled" id="714" />
-          <Map s="FIRST_NEIGHBOR|..|Transcellular absorption sink condition" id="715" />
-          <Map s="SinkCondition_trans" id="716" />
-          <Map s="..|pKa_pH_WS_cell_K1" id="717" />
-          <Map s="..|pKa_pH_WS_cell_K2" id="718" />
-          <Map s="..|pKa_pH_WS_cell_K3" id="719" />
-          <Map s="..|pKa_pH_WS_cell_K4" id="720" />
-          <Map s="..|pKa_pH_WS_cell_K5" id="721" />
-          <Map s="..|pKa_pH_WS_cell_K6" id="722" />
-          <Map s="..|pKa_pH_WS_cell_K7" id="723" />
-          <Map s="..|pKa_pH_WS_cell_K8" id="724" />
-          <Map s="MOLECULE|base_For_Pint_Factor" id="725" />
-          <Map s="MOLECULE|Use pH- and pKa-dependent penalty factor for charged molecule fraction" id="726" />
-          <Map s="UsePenaltyFactor" id="727" />
-          <Map s="Neighborhoods|UpperJejunum_int_UpperJejunum_cell|MOLECULE|Partition coefficient (intracellular/plasma)" id="728" />
-          <Map s="SECOND_NEIGHBOR|pH" id="729" />
-          <Map s="FIRST_NEIGHBOR|pH" id="730" />
-          <Map s="MOLECULE|Intestinal permeability (paracellular)" id="731" />
-          <Map s="P_int_para" id="732" />
-          <Map s="FIRST_NEIGHBOR|..|Paracellular absorption sink condition" id="733" />
-          <Map s="SinkCondition_para" id="734" />
-          <Map s="C_bc" id="735" />
-          <Map s="Organism|Lumen|Caecum|MOLECULE|Oral mass absorbed segment" id="736" />
-          <Map s="MAbs_cae" id="737" />
-          <Map s="Organism|Lumen|ColonAscendens|MOLECULE|Oral mass absorbed segment" id="738" />
-          <Map s="MAbs_colasc" id="739" />
-          <Map s="Organism|Lumen|ColonDescendens|MOLECULE|Oral mass absorbed segment" id="740" />
-          <Map s="MAbs_coldesc" id="741" />
-          <Map s="Organism|Lumen|ColonSigmoid|MOLECULE|Oral mass absorbed segment" id="742" />
-          <Map s="MAbs_colsigm" id="743" />
-          <Map s="Organism|Lumen|ColonTransversum|MOLECULE|Oral mass absorbed segment" id="744" />
-          <Map s="MAbs_coltrans" id="745" />
-          <Map s="Organism|Lumen|Duodenum|MOLECULE|Oral mass absorbed segment" id="746" />
-          <Map s="MAbs_duo" id="747" />
-          <Map s="Organism|Lumen|LowerIleum|MOLECULE|Oral mass absorbed segment" id="748" />
-          <Map s="MAbs_lil" id="749" />
-          <Map s="Organism|Lumen|LowerJejunum|MOLECULE|Oral mass absorbed segment" id="750" />
-          <Map s="MAbs_lje" id="751" />
-          <Map s="Organism|Lumen|Rectum|MOLECULE|Oral mass absorbed segment" id="752" />
-          <Map s="MAbs_rect" id="753" />
-          <Map s="Organism|Lumen|UpperIleum|MOLECULE|Oral mass absorbed segment" id="754" />
-          <Map s="MAbs_uil" id="755" />
-          <Map s="Organism|Lumen|UpperJejunum|MOLECULE|Oral mass absorbed segment" id="756" />
-          <Map s="MAbs_uje" id="757" />
-          <Map s="Neighborhoods|LowerJejunum_int_LowerJejunum_cell|MOLECULE|Partition coefficient (intracellular/plasma)" id="758" />
-          <Map s="Neighborhoods|UpperIleum_int_UpperIleum_cell|MOLECULE|Partition coefficient (intracellular/plasma)" id="759" />
-          <Map s="SECOND_NEIGHBOR|..|Blood flow rate" id="760" />
-          <Map s="Neighborhoods|LowerIleum_int_LowerIleum_cell|MOLECULE|Partition coefficient (intracellular/plasma)" id="761" />
-          <Map s="Organism|SmallIntestine|Volume (mucosa)" id="762" />
-          <Map s="FIRST_NEIGHBOR|..|Volume (mucosa)" id="763" />
-          <Map s="Organism|LargeIntestine|Volume (mucosa)" id="764" />
-          <Map s="..|P*SA interstitial -&gt; intracellular" id="765" />
-          <Map s="PA_liv" id="766" />
-          <Map s="FIRST_NEIGHBOR|..|..|PortalVein|Blood flow rate" id="767" />
-          <Map s="Q_pve" id="768" />
-          <Map s="Neighborhoods|Rectum_int_Rectum_cell|MOLECULE|Partition coefficient (intracellular/plasma)" id="769" />
-          <Map s="..|SalivaPlasmaRatio" id="770" />
-          <Map s="R" id="771" />
-          <Map s="SECOND_NEIGHBOR|pH (saliva)" id="772" />
-          <Map s="pH_slv" id="773" />
-          <Map s="Organism|pH (plasma)" id="774" />
-          <Map s="pH_PLS" id="775" />
-          <Map s="Organism|Lumen|Duodenum|Effective surface area enhancement factor" id="776" />
-          <Map s="Organism|Lumen|Duodenum|Geometric surface area" id="777" />
-          <Map s="Organism|Lumen|Duodenum|Microvilli factor" id="778" />
-          <Map s="MicrovilliFactor" id="779" />
-          <Map s="MOLECULE|Mucosa permeability scale factor (transcellular)" id="780" />
-          <Map s="P_int_scalefactor" id="781" />
-          <Map s="Organism|Lumen|UpperJejunum|Effective surface area enhancement factor" id="782" />
-          <Map s="Organism|Lumen|UpperJejunum|Geometric surface area" id="783" />
-          <Map s="Organism|Lumen|UpperJejunum|Microvilli factor" id="784" />
-          <Map s="Organism|Lumen|LowerJejunum|Effective surface area enhancement factor" id="785" />
-          <Map s="Organism|Lumen|LowerJejunum|Geometric surface area" id="786" />
-          <Map s="Organism|Lumen|LowerJejunum|Microvilli factor" id="787" />
-          <Map s="Organism|Lumen|UpperIleum|Effective surface area enhancement factor" id="788" />
-          <Map s="Organism|Lumen|UpperIleum|Geometric surface area" id="789" />
-          <Map s="Organism|Lumen|UpperIleum|Microvilli factor" id="790" />
-          <Map s="Organism|Lumen|LowerIleum|Effective surface area enhancement factor" id="791" />
-          <Map s="Organism|Lumen|LowerIleum|Geometric surface area" id="792" />
-          <Map s="Organism|Lumen|LowerIleum|Microvilli factor" id="793" />
-          <Map s="Organism|Lumen|Caecum|Effective surface area enhancement factor" id="794" />
-          <Map s="Organism|Lumen|Caecum|Geometric surface area" id="795" />
-          <Map s="Organism|Lumen|Caecum|Microvilli factor" id="796" />
-          <Map s="Organism|Lumen|ColonAscendens|Effective surface area enhancement factor" id="797" />
-          <Map s="Organism|Lumen|ColonAscendens|Geometric surface area" id="798" />
-          <Map s="Organism|Lumen|ColonAscendens|Microvilli factor" id="799" />
-          <Map s="Organism|Lumen|ColonTransversum|Effective surface area enhancement factor" id="800" />
-          <Map s="Organism|Lumen|ColonTransversum|Geometric surface area" id="801" />
-          <Map s="Organism|Lumen|ColonTransversum|Microvilli factor" id="802" />
-          <Map s="Organism|Lumen|ColonDescendens|Effective surface area enhancement factor" id="803" />
-          <Map s="Organism|Lumen|ColonDescendens|Geometric surface area" id="804" />
-          <Map s="Organism|Lumen|ColonDescendens|Microvilli factor" id="805" />
-          <Map s="Organism|Lumen|ColonSigmoid|Effective surface area enhancement factor" id="806" />
-          <Map s="Organism|Lumen|ColonSigmoid|Geometric surface area" id="807" />
-          <Map s="Organism|Lumen|ColonSigmoid|Microvilli factor" id="808" />
-          <Map s="Organism|Lumen|Rectum|Effective surface area enhancement factor" id="809" />
-          <Map s="Organism|Lumen|Rectum|Geometric surface area" id="810" />
-          <Map s="Organism|Lumen|Rectum|Microvilli factor" id="811" />
-          <Map s="Neighborhoods|Caecum_int_Caecum_cell|MOLECULE|Partition coefficient (intracellular/plasma)" id="812" />
-          <Map s="Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|MOLECULE|Partition coefficient (intracellular/plasma)" id="813" />
-          <Map s="Neighborhoods|ColonDescendens_int_ColonDescendens_cell|MOLECULE|Partition coefficient (intracellular/plasma)" id="814" />
-          <Map s="Neighborhoods|ColonTransversum_int_ColonTransversum_cell|MOLECULE|Partition coefficient (intracellular/plasma)" id="815" />
-          <Map s="Neighborhoods|ColonAscendens_int_ColonAscendens_cell|MOLECULE|Partition coefficient (intracellular/plasma)" id="816" />
-          <Map s="Neighborhoods|Duodenum_int_Duodenum_cell|MOLECULE|Partition coefficient (intracellular/plasma)" id="817" />
-          <Map s="Mean" id="818" />
-          <Map s="Deviation" id="819" />
-          <Map s="GeometricDeviation" id="820" />
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-          <Map s="Organism|Skin|Acidic phospholipids [mg/g] - RR" id="402" />
-          <Map s="Organism|Spleen|Density (tissue)" id="403" />
-          <Map s="Organism|Spleen|Allometric scale factor" id="404" />
-          <Map s="Organism|Spleen|Fraction of blood for sampling" id="405" />
-          <Map s="Organism|Spleen|Radius (small pores)" id="406" />
-          <Map s="Organism|Spleen|Flow fraction via large pores" id="407" />
-          <Map s="Organism|Spleen|Radius (large pores)" id="408" />
-          <Map s="Organism|Spleen|Hydraulic conductivity" id="409" />
-          <Map s="Organism|Spleen|Vf (lipid)" id="410" />
-          <Map s="Organism|Spleen|Vf (neutral lipid)-PT" id="411" />
-          <Map s="Organism|Spleen|Fraction vascular" id="412" />
-          <Map s="Organism|Spleen|Vf (phospholipid)-PT" id="413" />
-          <Map s="Organism|Spleen|Vf (protein)" id="414" />
-          <Map s="Organism|Spleen|Albumin ratio (tissue/plasma)-PT" id="415" />
-          <Map s="Organism|Spleen|Lipoprotein ratio (tissue/plasma)" id="416" />
-          <Map s="Organism|Spleen|Vf (water)" id="417" />
-          <Map s="Organism|Spleen|Albumin ratio (tissue/plasma)" id="418" />
-          <Map s="Organism|Spleen|Vf (water)-PT" id="419" />
-          <Map s="Organism|Spleen|Fraction interstitial" id="420" />
-          <Map s="Organism|Spleen|Vf (neutral lipid)-WS" id="421" />
-          <Map s="Organism|Spleen|Vf (neutral lipid)-RR" id="422" />
-          <Map s="Organism|Spleen|Vf (neutral phospholipid)-RR" id="423" />
-          <Map s="Organism|Spleen|Vf (neutral phospholipid, plasma)-WS" id="424" />
-          <Map s="Organism|Spleen|Vf (extracellular water)-RR" id="425" />
-          <Map s="Organism|Spleen|Vf (protein)-WS" id="426" />
-          <Map s="Organism|Spleen|Vf (intracellular water)-RR" id="427" />
-          <Map s="Organism|Spleen|Vf (water)-WS" id="428" />
-          <Map s="Organism|Spleen|Vf (acidic phospholipids)-WS" id="429" />
-          <Map s="Organism|Spleen|Acidic phospholipids [mg/g] - RR" id="430" />
-          <Map s="Organism|Saliva|Density (tissue)" id="431" />
-          <Map s="Organism|Saliva|Saliva flow rate" id="432" />
-          <Map s="Organism|VenousBlood|Volume|Percentile" id="433" />
-          <Map s="Organism|VenousBlood|Volume|Mean" id="434" />
-          <Map s="Organism|VenousBlood|Volume|Deviation" id="435" />
-          <Map s="Organism|ArterialBlood|Volume|Percentile" id="436" />
-          <Map s="Organism|ArterialBlood|Volume|Mean" id="437" />
-          <Map s="Organism|ArterialBlood|Volume|Deviation" id="438" />
-          <Map s="Organism|Bone|Specific blood flow rate|Percentile" id="439" />
-          <Map s="Organism|Bone|Specific blood flow rate|Mean" id="440" />
-          <Map s="Organism|Bone|Specific blood flow rate|Deviation" id="441" />
-          <Map s="Organism|Bone|Volume|Percentile" id="442" />
-          <Map s="Organism|Bone|Volume|Mean" id="443" />
-          <Map s="Organism|Bone|Volume|Deviation" id="444" />
-          <Map s="Organism|Bone|Intracellular|pH" id="445" />
-          <Map s="Organism|Brain|Volume|Percentile" id="446" />
-          <Map s="Organism|Brain|Volume|Mean" id="447" />
-          <Map s="Organism|Brain|Volume|Deviation" id="448" />
-          <Map s="Organism|Brain|Specific blood flow rate|Percentile" id="449" />
-          <Map s="Organism|Brain|Specific blood flow rate|Mean" id="450" />
-          <Map s="Organism|Brain|Specific blood flow rate|Deviation" id="451" />
-          <Map s="Organism|Brain|Intracellular|pH" id="452" />
-          <Map s="Organism|Fat|Volume|Percentile" id="453" />
-          <Map s="Organism|Fat|Volume|Mean" id="454" />
-          <Map s="Organism|Fat|Volume|GeometricDeviation" id="455" />
-          <Map s="Organism|Fat|Vf (lipid)|Percentile" id="456" />
-          <Map s="Organism|Fat|Vf (lipid)|Mean" id="457" />
-          <Map s="Organism|Fat|Vf (neutral lipid)-PT|Percentile" id="458" />
-          <Map s="Organism|Fat|Vf (neutral lipid)-PT|Mean" id="459" />
-          <Map s="Organism|Fat|Vf (phospholipid)-PT|Percentile" id="460" />
-          <Map s="Organism|Fat|Vf (phospholipid)-PT|Mean" id="461" />
-          <Map s="Organism|Fat|Fraction interstitial|Percentile" id="462" />
-          <Map s="Organism|Fat|Fraction interstitial|Mean" id="463" />
-          <Map s="Organism|Fat|Vf (water)-PT|Percentile" id="464" />
-          <Map s="Organism|Fat|Vf (water)-PT|Mean" id="465" />
-          <Map s="Organism|Fat|Vf (water)|Percentile" id="466" />
-          <Map s="Organism|Fat|Vf (water)|Mean" id="467" />
-          <Map s="Organism|Fat|Vf (neutral lipid)-WS|Percentile" id="468" />
-          <Map s="Organism|Fat|Vf (neutral lipid)-WS|Mean" id="469" />
-          <Map s="Organism|Fat|Vf (neutral lipid)-RR|Percentile" id="470" />
-          <Map s="Organism|Fat|Vf (neutral lipid)-RR|Mean" id="471" />
-          <Map s="Organism|Fat|Vf (neutral phospholipid, plasma)-WS|Percentile" id="472" />
-          <Map s="Organism|Fat|Vf (neutral phospholipid, plasma)-WS|Mean" id="473" />
-          <Map s="Organism|Fat|Vf (neutral phospholipid)-RR|Percentile" id="474" />
-          <Map s="Organism|Fat|Vf (neutral phospholipid)-RR|Mean" id="475" />
-          <Map s="Organism|Fat|Vf (extracellular water)-RR|Percentile" id="476" />
-          <Map s="Organism|Fat|Vf (extracellular water)-RR|Mean" id="477" />
-          <Map s="Organism|Fat|Vf (intracellular water)-RR|Percentile" id="478" />
-          <Map s="Organism|Fat|Vf (intracellular water)-RR|Mean" id="479" />
-          <Map s="Organism|Fat|Vf (water)-WS|Percentile" id="480" />
-          <Map s="Organism|Fat|Vf (water)-WS|Mean" id="481" />
-          <Map s="Organism|Fat|Specific blood flow rate|Percentile" id="482" />
-          <Map s="Organism|Fat|Specific blood flow rate|Mean" id="483" />
-          <Map s="Organism|Fat|Specific blood flow rate|Deviation" id="484" />
-          <Map s="Organism|Fat|Intracellular|pH" id="485" />
-          <Map s="Organism|Gonads|Volume|Percentile" id="486" />
-          <Map s="Organism|Gonads|Volume|Mean" id="487" />
-          <Map s="Organism|Gonads|Volume|Deviation" id="488" />
-          <Map s="Organism|Gonads|Specific blood flow rate|Percentile" id="489" />
-          <Map s="Organism|Gonads|Specific blood flow rate|Mean" id="490" />
-          <Map s="Organism|Gonads|Specific blood flow rate|Deviation" id="491" />
-          <Map s="Organism|Gonads|Intracellular|pH" id="492" />
-          <Map s="Organism|Heart|Volume|Percentile" id="493" />
-          <Map s="Organism|Heart|Volume|Mean" id="494" />
-          <Map s="Organism|Heart|Volume|Deviation" id="495" />
-          <Map s="Organism|Heart|Specific blood flow rate|Percentile" id="496" />
-          <Map s="Organism|Heart|Specific blood flow rate|Mean" id="497" />
-          <Map s="Organism|Heart|Specific blood flow rate|Deviation" id="498" />
-          <Map s="Organism|Heart|Intracellular|pH" id="499" />
-          <Map s="Organism|Kidney|Volume|Percentile" id="500" />
-          <Map s="Organism|Kidney|Volume|Mean" id="501" />
-          <Map s="Organism|Kidney|Volume|Deviation" id="502" />
-          <Map s="Organism|Kidney|Hill coefficient for GFR|Percentile" id="503" />
-          <Map s="Organism|Kidney|Hill coefficient for GFR|Mean" id="504" />
-          <Map s="Organism|Kidney|Hill coefficient for GFR|Deviation" id="505" />
-          <Map s="Organism|Kidney|TM50 for GFR|Percentile" id="506" />
-          <Map s="Organism|Kidney|TM50 for GFR|Mean" id="507" />
-          <Map s="Organism|Kidney|TM50 for GFR|Deviation" id="508" />
-          <Map s="Organism|Kidney|GFRmat|Percentile" id="509" />
-          <Map s="Organism|Kidney|GFRmat|Mean" id="510" />
-          <Map s="Organism|Kidney|GFRmat|Deviation" id="511" />
-          <Map s="Organism|Kidney|Specific blood flow rate|Percentile" id="512" />
-          <Map s="Organism|Kidney|Specific blood flow rate|Mean" id="513" />
-          <Map s="Organism|Kidney|Specific blood flow rate|Deviation" id="514" />
-          <Map s="Organism|Kidney|Intracellular|pH" id="515" />
-          <Map s="Organism|Kidney|Urine|Volume" id="516" />
-          <Map s="Organism|Lumen|Stomach|Absorption of liquid" id="517" />
-          <Map s="Organism|Lumen|Stomach|GET of non-disintegrated moiety" id="518" />
-          <Map s="Organism|Lumen|Stomach|Inverse rate of inflow of liquid into stomach" id="519" />
-          <Map s="Organism|Lumen|Stomach|pH in fasted state" id="520" />
-          <Map s="Organism|Lumen|Stomach|Fractional steady state fill level" id="521" />
-          <Map s="Organism|Lumen|Stomach|Thickness of gut wall" id="522" />
-          <Map s="Organism|Lumen|Stomach|pH in fed state" id="523" />
-          <Map s="Organism|Lumen|Stomach|C1|Partition coefficient (water/container)" id="524" />
-          <Map s="Organism|Lumen|Duodenum|pH" id="525" />
-          <Map s="Organism|Lumen|Duodenum|Thickness_p3" id="526" />
-          <Map s="Organism|Lumen|Duodenum|Microvilli factor" id="527" />
-          <Map s="Organism|Lumen|Duodenum|Thickness_p1" id="528" />
-          <Map s="Organism|Lumen|Duodenum|r2_p1" id="529" />
-          <Map s="Organism|Lumen|Duodenum|r2_p0" id="530" />
-          <Map s="Organism|Lumen|Duodenum|r1_p1" id="531" />
-          <Map s="Organism|Lumen|Duodenum|r1_p0" id="532" />
-          <Map s="Organism|Lumen|Duodenum|L_p1" id="533" />
-          <Map s="Organism|Lumen|Duodenum|L_p0" id="534" />
-          <Map s="Organism|Lumen|Duodenum|Intestinal transit rate" id="535" />
-          <Map s="Organism|Lumen|Duodenum|Fractional steady state fill level" id="536" />
-          <Map s="Organism|Lumen|Duodenum|Thickness_p2" id="537" />
-          <Map s="Organism|Lumen|Duodenum|C1|Oral mass absorbed segment" id="538" />
-          <Map s="Organism|Lumen|Duodenum|C1|Partition coefficient (water/container)" id="539" />
-          <Map s="Organism|Lumen|UpperJejunum|pH" id="540" />
-          <Map s="Organism|Lumen|UpperJejunum|Thickness_p3" id="541" />
-          <Map s="Organism|Lumen|UpperJejunum|L_p1" id="542" />
-          <Map s="Organism|Lumen|UpperJejunum|r1_p1" id="543" />
-          <Map s="Organism|Lumen|UpperJejunum|r1_p0" id="544" />
-          <Map s="Organism|Lumen|UpperJejunum|L_p0" id="545" />
-          <Map s="Organism|Lumen|UpperJejunum|Intestinal transit rate" id="546" />
-          <Map s="Organism|Lumen|UpperJejunum|Fractional steady state fill level" id="547" />
-          <Map s="Organism|Lumen|UpperJejunum|Microvilli factor" id="548" />
-          <Map s="Organism|Lumen|UpperJejunum|Thickness_p2" id="549" />
-          <Map s="Organism|Lumen|UpperJejunum|Thickness_p1" id="550" />
-          <Map s="Organism|Lumen|UpperJejunum|r2_p1" id="551" />
-          <Map s="Organism|Lumen|UpperJejunum|r2_p0" id="552" />
-          <Map s="Organism|Lumen|UpperJejunum|C1|Partition coefficient (water/container)" id="553" />
-          <Map s="Organism|Lumen|UpperJejunum|C1|Oral mass absorbed segment" id="554" />
-          <Map s="Organism|Lumen|LowerJejunum|r1_p0" id="555" />
-          <Map s="Organism|Lumen|LowerJejunum|Thickness_p3" id="556" />
-          <Map s="Organism|Lumen|LowerJejunum|Thickness_p2" id="557" />
-          <Map s="Organism|Lumen|LowerJejunum|r2_p1" id="558" />
-          <Map s="Organism|Lumen|LowerJejunum|r2_p0" id="559" />
-          <Map s="Organism|Lumen|LowerJejunum|r1_p1" id="560" />
-          <Map s="Organism|Lumen|LowerJejunum|Microvilli factor" id="561" />
-          <Map s="Organism|Lumen|LowerJejunum|L_p1" id="562" />
-          <Map s="Organism|Lumen|LowerJejunum|L_p0" id="563" />
-          <Map s="Organism|Lumen|LowerJejunum|Intestinal transit rate" id="564" />
-          <Map s="Organism|Lumen|LowerJejunum|Fractional steady state fill level" id="565" />
-          <Map s="Organism|Lumen|LowerJejunum|Thickness_p1" id="566" />
-          <Map s="Organism|Lumen|LowerJejunum|pH" id="567" />
-          <Map s="Organism|Lumen|LowerJejunum|C1|Oral mass absorbed segment" id="568" />
-          <Map s="Organism|Lumen|LowerJejunum|C1|Partition coefficient (water/container)" id="569" />
-          <Map s="Organism|Lumen|UpperIleum|Thickness_p3" id="570" />
-          <Map s="Organism|Lumen|UpperIleum|Intestinal transit rate" id="571" />
-          <Map s="Organism|Lumen|UpperIleum|Thickness_p2" id="572" />
-          <Map s="Organism|Lumen|UpperIleum|Thickness_p1" id="573" />
-          <Map s="Organism|Lumen|UpperIleum|r2_p1" id="574" />
-          <Map s="Organism|Lumen|UpperIleum|r2_p0" id="575" />
-          <Map s="Organism|Lumen|UpperIleum|r1_p1" id="576" />
-          <Map s="Organism|Lumen|UpperIleum|r1_p0" id="577" />
-          <Map s="Organism|Lumen|UpperIleum|Fractional steady state fill level" id="578" />
-          <Map s="Organism|Lumen|UpperIleum|Microvilli factor" id="579" />
-          <Map s="Organism|Lumen|UpperIleum|L_p1" id="580" />
-          <Map s="Organism|Lumen|UpperIleum|L_p0" id="581" />
-          <Map s="Organism|Lumen|UpperIleum|pH" id="582" />
-          <Map s="Organism|Lumen|UpperIleum|C1|Partition coefficient (water/container)" id="583" />
-          <Map s="Organism|Lumen|UpperIleum|C1|Oral mass absorbed segment" id="584" />
-          <Map s="Organism|Lumen|LowerIleum|Fractional steady state fill level" id="585" />
-          <Map s="Organism|Lumen|LowerIleum|r1_p0" id="586" />
-          <Map s="Organism|Lumen|LowerIleum|Thickness_p3" id="587" />
-          <Map s="Organism|Lumen|LowerIleum|Thickness_p2" id="588" />
-          <Map s="Organism|Lumen|LowerIleum|Thickness_p1" id="589" />
-          <Map s="Organism|Lumen|LowerIleum|r2_p1" id="590" />
-          <Map s="Organism|Lumen|LowerIleum|r2_p0" id="591" />
-          <Map s="Organism|Lumen|LowerIleum|r1_p1" id="592" />
-          <Map s="Organism|Lumen|LowerIleum|pH" id="593" />
-          <Map s="Organism|Lumen|LowerIleum|Microvilli factor" id="594" />
-          <Map s="Organism|Lumen|LowerIleum|L_p1" id="595" />
-          <Map s="Organism|Lumen|LowerIleum|L_p0" id="596" />
-          <Map s="Organism|Lumen|LowerIleum|Intestinal transit rate" id="597" />
-          <Map s="Organism|Lumen|LowerIleum|C1|Oral mass absorbed segment" id="598" />
-          <Map s="Organism|Lumen|LowerIleum|C1|Partition coefficient (water/container)" id="599" />
-          <Map s="Organism|Lumen|Caecum|Fractional steady state fill level" id="600" />
-          <Map s="Organism|Lumen|Caecum|Thickness_p2" id="601" />
-          <Map s="Organism|Lumen|Caecum|Thickness_p1" id="602" />
-          <Map s="Organism|Lumen|Caecum|r2_p1" id="603" />
-          <Map s="Organism|Lumen|Caecum|r2_p0" id="604" />
-          <Map s="Organism|Lumen|Caecum|r1_p1" id="605" />
-          <Map s="Organism|Lumen|Caecum|r1_p0" id="606" />
-          <Map s="Organism|Lumen|Caecum|Microvilli factor" id="607" />
-          <Map s="Organism|Lumen|Caecum|L_p1" id="608" />
-          <Map s="Organism|Lumen|Caecum|L_p0" id="609" />
-          <Map s="Organism|Lumen|Caecum|Intestinal transit rate" id="610" />
-          <Map s="Organism|Lumen|Caecum|Thickness_p3" id="611" />
-          <Map s="Organism|Lumen|Caecum|pH" id="612" />
-          <Map s="Organism|Lumen|Caecum|C1|Oral mass absorbed segment" id="613" />
-          <Map s="Organism|Lumen|Caecum|C1|Partition coefficient (water/container)" id="614" />
-          <Map s="Organism|Lumen|ColonAscendens|Thickness_p3" id="615" />
-          <Map s="Organism|Lumen|ColonAscendens|Thickness_p2" id="616" />
-          <Map s="Organism|Lumen|ColonAscendens|Thickness_p1" id="617" />
-          <Map s="Organism|Lumen|ColonAscendens|r2_p0" id="618" />
-          <Map s="Organism|Lumen|ColonAscendens|r1_p1" id="619" />
-          <Map s="Organism|Lumen|ColonAscendens|r1_p0" id="620" />
-          <Map s="Organism|Lumen|ColonAscendens|pH" id="621" />
-          <Map s="Organism|Lumen|ColonAscendens|r2_p1" id="622" />
-          <Map s="Organism|Lumen|ColonAscendens|Microvilli factor" id="623" />
-          <Map s="Organism|Lumen|ColonAscendens|L_p1" id="624" />
-          <Map s="Organism|Lumen|ColonAscendens|L_p0" id="625" />
-          <Map s="Organism|Lumen|ColonAscendens|Intestinal transit rate" id="626" />
-          <Map s="Organism|Lumen|ColonAscendens|Fractional steady state fill level" id="627" />
-          <Map s="Organism|Lumen|ColonAscendens|C1|Oral mass absorbed segment" id="628" />
-          <Map s="Organism|Lumen|ColonAscendens|C1|Partition coefficient (water/container)" id="629" />
-          <Map s="Organism|Lumen|ColonTransversum|Fractional steady state fill level" id="630" />
-          <Map s="Organism|Lumen|ColonTransversum|L_p0" id="631" />
-          <Map s="Organism|Lumen|ColonTransversum|r2_p0" id="632" />
-          <Map s="Organism|Lumen|ColonTransversum|Thickness_p3" id="633" />
-          <Map s="Organism|Lumen|ColonTransversum|Thickness_p2" id="634" />
-          <Map s="Organism|Lumen|ColonTransversum|Thickness_p1" id="635" />
-          <Map s="Organism|Lumen|ColonTransversum|Intestinal transit rate" id="636" />
-          <Map s="Organism|Lumen|ColonTransversum|r2_p1" id="637" />
-          <Map s="Organism|Lumen|ColonTransversum|r1_p1" id="638" />
-          <Map s="Organism|Lumen|ColonTransversum|r1_p0" id="639" />
-          <Map s="Organism|Lumen|ColonTransversum|pH" id="640" />
-          <Map s="Organism|Lumen|ColonTransversum|Microvilli factor" id="641" />
-          <Map s="Organism|Lumen|ColonTransversum|L_p1" id="642" />
-          <Map s="Organism|Lumen|ColonTransversum|C1|Oral mass absorbed segment" id="643" />
-          <Map s="Organism|Lumen|ColonTransversum|C1|Partition coefficient (water/container)" id="644" />
-          <Map s="Organism|Lumen|ColonDescendens|r1_p0" id="645" />
-          <Map s="Organism|Lumen|ColonDescendens|r2_p1" id="646" />
-          <Map s="Organism|Lumen|ColonDescendens|r2_p0" id="647" />
-          <Map s="Organism|Lumen|ColonDescendens|pH" id="648" />
-          <Map s="Organism|Lumen|ColonDescendens|Microvilli factor" id="649" />
-          <Map s="Organism|Lumen|ColonDescendens|L_p1" id="650" />
-          <Map s="Organism|Lumen|ColonDescendens|L_p0" id="651" />
-          <Map s="Organism|Lumen|ColonDescendens|Intestinal transit rate" id="652" />
-          <Map s="Organism|Lumen|ColonDescendens|r1_p1" id="653" />
-          <Map s="Organism|Lumen|ColonDescendens|Thickness_p3" id="654" />
-          <Map s="Organism|Lumen|ColonDescendens|Thickness_p2" id="655" />
-          <Map s="Organism|Lumen|ColonDescendens|Thickness_p1" id="656" />
-          <Map s="Organism|Lumen|ColonDescendens|Fractional steady state fill level" id="657" />
-          <Map s="Organism|Lumen|ColonDescendens|C1|Oral mass absorbed segment" id="658" />
-          <Map s="Organism|Lumen|ColonDescendens|C1|Partition coefficient (water/container)" id="659" />
-          <Map s="Organism|Lumen|ColonSigmoid|r2_p0" id="660" />
-          <Map s="Organism|Lumen|ColonSigmoid|Thickness_p3" id="661" />
-          <Map s="Organism|Lumen|ColonSigmoid|Thickness_p2" id="662" />
-          <Map s="Organism|Lumen|ColonSigmoid|Thickness_p1" id="663" />
-          <Map s="Organism|Lumen|ColonSigmoid|Intestinal transit rate" id="664" />
-          <Map s="Organism|Lumen|ColonSigmoid|r1_p1" id="665" />
-          <Map s="Organism|Lumen|ColonSigmoid|r1_p0" id="666" />
-          <Map s="Organism|Lumen|ColonSigmoid|pH" id="667" />
-          <Map s="Organism|Lumen|ColonSigmoid|Microvilli factor" id="668" />
-          <Map s="Organism|Lumen|ColonSigmoid|L_p1" id="669" />
-          <Map s="Organism|Lumen|ColonSigmoid|r2_p1" id="670" />
-          <Map s="Organism|Lumen|ColonSigmoid|L_p0" id="671" />
-          <Map s="Organism|Lumen|ColonSigmoid|Fractional steady state fill level" id="672" />
-          <Map s="Organism|Lumen|ColonSigmoid|C1|Oral mass absorbed segment" id="673" />
-          <Map s="Organism|Lumen|ColonSigmoid|C1|Partition coefficient (water/container)" id="674" />
-          <Map s="Organism|Lumen|Rectum|Fractional steady state fill level" id="675" />
-          <Map s="Organism|Lumen|Rectum|Thickness_p2" id="676" />
-          <Map s="Organism|Lumen|Rectum|Thickness_p1" id="677" />
-          <Map s="Organism|Lumen|Rectum|r2_p1" id="678" />
-          <Map s="Organism|Lumen|Rectum|r2_p0" id="679" />
-          <Map s="Organism|Lumen|Rectum|r1_p1" id="680" />
-          <Map s="Organism|Lumen|Rectum|Intestinal transit rate" id="681" />
-          <Map s="Organism|Lumen|Rectum|L_p0" id="682" />
-          <Map s="Organism|Lumen|Rectum|pH" id="683" />
-          <Map s="Organism|Lumen|Rectum|Microvilli factor" id="684" />
-          <Map s="Organism|Lumen|Rectum|L_p1" id="685" />
-          <Map s="Organism|Lumen|Rectum|r1_p0" id="686" />
-          <Map s="Organism|Lumen|Rectum|Thickness_p3" id="687" />
-          <Map s="Organism|Lumen|Rectum|C1|Oral mass absorbed segment" id="688" />
-          <Map s="Organism|Lumen|Rectum|C1|Partition coefficient (water/container)" id="689" />
-          <Map s="Organism|Lumen|Feces|Liquid" id="690" />
-          <Map s="Organism|Lumen|Feces|Volume" id="691" />
-          <Map s="Organism|Lumen|Stomach|Length|Percentile" id="692" />
-          <Map s="Organism|Lumen|Stomach|Length|Mean" id="693" />
-          <Map s="Organism|Lumen|Stomach|GET_beta (Weibull function) variability factor|Percentile" id="694" />
-          <Map s="Organism|Lumen|Stomach|GET_beta (Weibull function) variability factor|Mean" id="695" />
-          <Map s="Organism|Lumen|Stomach|GET_beta (Weibull function) variability factor|GeometricDeviation" id="696" />
-          <Map s="Organism|Lumen|Stomach|GET_alpha (Weibull function) variability factor|Percentile" id="697" />
-          <Map s="Organism|Lumen|Stomach|GET_alpha (Weibull function) variability factor|Mean" id="698" />
-          <Map s="Organism|Lumen|Stomach|GET_alpha (Weibull function) variability factor|GeometricDeviation" id="699" />
-          <Map s="Organism|Lumen|Stomach|Gastric emptying time|Percentile" id="700" />
-          <Map s="Organism|Lumen|Stomach|Gastric emptying time|Mean" id="701" />
-          <Map s="Organism|Lumen|Stomach|Gastric emptying time|GeometricDeviation" id="702" />
-          <Map s="Organism|Lumen|Stomach|Distal radius|Percentile" id="703" />
-          <Map s="Organism|Lumen|Stomach|Distal radius|Mean" id="704" />
-          <Map s="Organism|Lumen|Stomach|Proximal radius|Percentile" id="705" />
-          <Map s="Organism|Lumen|Stomach|Proximal radius|Mean" id="706" />
-          <Map s="Organism|Lumen|Duodenum|Effective surface area enhancement factor|Percentile" id="707" />
-          <Map s="Organism|Lumen|Duodenum|Effective surface area enhancement factor|Mean" id="708" />
-          <Map s="Organism|Lumen|UpperJejunum|Effective surface area enhancement factor|Percentile" id="709" />
-          <Map s="Organism|Lumen|UpperJejunum|Effective surface area enhancement factor|Mean" id="710" />
-          <Map s="Organism|Lumen|LowerJejunum|Effective surface area enhancement factor|Percentile" id="711" />
-          <Map s="Organism|Lumen|LowerJejunum|Effective surface area enhancement factor|Mean" id="712" />
-          <Map s="Organism|Lumen|UpperIleum|Effective surface area enhancement factor|Percentile" id="713" />
-          <Map s="Organism|Lumen|UpperIleum|Effective surface area enhancement factor|Mean" id="714" />
-          <Map s="Organism|Lumen|LowerIleum|Effective surface area enhancement factor|Percentile" id="715" />
-          <Map s="Organism|Lumen|LowerIleum|Effective surface area enhancement factor|Mean" id="716" />
-          <Map s="Organism|Lumen|Caecum|Effective surface area enhancement factor|Percentile" id="717" />
-          <Map s="Organism|Lumen|Caecum|Effective surface area enhancement factor|Mean" id="718" />
-          <Map s="Organism|Lumen|ColonAscendens|Effective surface area enhancement factor|Percentile" id="719" />
-          <Map s="Organism|Lumen|ColonAscendens|Effective surface area enhancement factor|Mean" id="720" />
-          <Map s="Organism|Lumen|ColonTransversum|Effective surface area enhancement factor|Percentile" id="721" />
-          <Map s="Organism|Lumen|ColonTransversum|Effective surface area enhancement factor|Mean" id="722" />
-          <Map s="Organism|Lumen|ColonDescendens|Effective surface area enhancement factor|Percentile" id="723" />
-          <Map s="Organism|Lumen|ColonDescendens|Effective surface area enhancement factor|Mean" id="724" />
-          <Map s="Organism|Lumen|ColonSigmoid|Effective surface area enhancement factor|Percentile" id="725" />
-          <Map s="Organism|Lumen|ColonSigmoid|Effective surface area enhancement factor|Mean" id="726" />
-          <Map s="Organism|Lumen|Rectum|Effective surface area enhancement factor|Percentile" id="727" />
-          <Map s="Organism|Lumen|Rectum|Effective surface area enhancement factor|Mean" id="728" />
-          <Map s="Organism|Stomach|Volume|Percentile" id="729" />
-          <Map s="Organism|Stomach|Volume|Mean" id="730" />
-          <Map s="Organism|Stomach|Volume|Deviation" id="731" />
-          <Map s="Organism|Stomach|Specific blood flow rate|Percentile" id="732" />
-          <Map s="Organism|Stomach|Specific blood flow rate|Mean" id="733" />
-          <Map s="Organism|Stomach|Specific blood flow rate|Deviation" id="734" />
-          <Map s="Organism|Stomach|Intracellular|pH" id="735" />
-          <Map s="Organism|SmallIntestine|Small intestinal transit time|Percentile" id="736" />
-          <Map s="Organism|SmallIntestine|Small intestinal transit time|Mean" id="737" />
-          <Map s="Organism|SmallIntestine|Small intestinal transit time|GeometricDeviation" id="738" />
-          <Map s="Organism|SmallIntestine|Volume|Percentile" id="739" />
-          <Map s="Organism|SmallIntestine|Volume|Mean" id="740" />
-          <Map s="Organism|SmallIntestine|Volume|Deviation" id="741" />
-          <Map s="Organism|SmallIntestine|Specific blood flow rate|Percentile" id="742" />
-          <Map s="Organism|SmallIntestine|Specific blood flow rate|Mean" id="743" />
-          <Map s="Organism|SmallIntestine|Specific blood flow rate|Deviation" id="744" />
-          <Map s="Organism|SmallIntestine|Intracellular|pH" id="745" />
-          <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Density (tissue)" id="746" />
-          <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Fraction of blood for sampling" id="747" />
-          <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Fraction of regional blood flow rate" id="748" />
-          <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Fraction mucosa" id="749" />
-          <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Hydraulic conductivity" id="750" />
-          <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Radius (large pores)" id="751" />
-          <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Flow fraction via large pores" id="752" />
-          <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Radius (small pores)" id="753" />
-          <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Vf (lipid)" id="754" />
-          <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Vf (neutral lipid)-PT" id="755" />
-          <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Fraction vascular" id="756" />
-          <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Vf (phospholipid)-PT" id="757" />
-          <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Vf (protein)" id="758" />
-          <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Albumin ratio (tissue/plasma)" id="759" />
-          <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Lipoprotein ratio (tissue/plasma)" id="760" />
-          <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Albumin ratio (tissue/plasma)-PT" id="761" />
-          <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Vf (water)-PT" id="762" />
-          <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Vf (water)" id="763" />
-          <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Fraction interstitial" id="764" />
-          <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Vf (neutral lipid)-WS" id="765" />
-          <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Vf (neutral lipid)-RR" id="766" />
-          <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Vf (neutral phospholipid, plasma)-WS" id="767" />
-          <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Vf (neutral phospholipid)-RR" id="768" />
-          <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Vf (protein)-WS" id="769" />
-          <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Vf (extracellular water)-RR" id="770" />
-          <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Vf (intracellular water)-RR" id="771" />
-          <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Vf (water)-WS" id="772" />
-          <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Acidic phospholipids [mg/g] - RR" id="773" />
-          <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Vf (acidic phospholipids)-WS" id="774" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Density (tissue)" id="775" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Fraction of blood for sampling" id="776" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Fraction mucosa" id="777" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Fraction of regional blood flow rate" id="778" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Hydraulic conductivity" id="779" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Flow fraction via large pores" id="780" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Radius (small pores)" id="781" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Radius (large pores)" id="782" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Vf (lipid)" id="783" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Vf (neutral lipid)-PT" id="784" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Fraction vascular" id="785" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Vf (protein)" id="786" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Vf (phospholipid)-PT" id="787" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Vf (water)-PT" id="788" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Lipoprotein ratio (tissue/plasma)" id="789" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Albumin ratio (tissue/plasma)-PT" id="790" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Vf (water)" id="791" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Albumin ratio (tissue/plasma)" id="792" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Fraction interstitial" id="793" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Vf (neutral lipid)-RR" id="794" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Vf (neutral lipid)-WS" id="795" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Vf (neutral phospholipid, plasma)-WS" id="796" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Vf (neutral phospholipid)-RR" id="797" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Vf (protein)-WS" id="798" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Vf (extracellular water)-RR" id="799" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Vf (water)-WS" id="800" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Vf (intracellular water)-RR" id="801" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Acidic phospholipids [mg/g] - RR" id="802" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Vf (acidic phospholipids)-WS" id="803" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Density (tissue)" id="804" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Fraction of blood for sampling" id="805" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Fraction of regional blood flow rate" id="806" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Fraction mucosa" id="807" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Radius (small pores)" id="808" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Flow fraction via large pores" id="809" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Hydraulic conductivity" id="810" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Radius (large pores)" id="811" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Vf (neutral lipid)-PT" id="812" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Vf (lipid)" id="813" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Fraction vascular" id="814" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Vf (phospholipid)-PT" id="815" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Vf (protein)" id="816" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Albumin ratio (tissue/plasma)" id="817" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Lipoprotein ratio (tissue/plasma)" id="818" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Albumin ratio (tissue/plasma)-PT" id="819" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Vf (water)" id="820" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Vf (water)-PT" id="821" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Fraction interstitial" id="822" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Vf (neutral lipid)-WS" id="823" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Vf (neutral lipid)-RR" id="824" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Vf (neutral phospholipid, plasma)-WS" id="825" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Vf (neutral phospholipid)-RR" id="826" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Vf (extracellular water)-RR" id="827" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Vf (protein)-WS" id="828" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Vf (intracellular water)-RR" id="829" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Vf (water)-WS" id="830" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Vf (acidic phospholipids)-WS" id="831" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Acidic phospholipids [mg/g] - RR" id="832" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Density (tissue)" id="833" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Fraction of blood for sampling" id="834" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Fraction mucosa" id="835" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Fraction of regional blood flow rate" id="836" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Radius (large pores)" id="837" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Hydraulic conductivity" id="838" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Flow fraction via large pores" id="839" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Radius (small pores)" id="840" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Vf (lipid)" id="841" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Vf (neutral lipid)-PT" id="842" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Fraction vascular" id="843" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Vf (protein)" id="844" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Vf (phospholipid)-PT" id="845" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Vf (water)" id="846" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Albumin ratio (tissue/plasma)" id="847" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Lipoprotein ratio (tissue/plasma)" id="848" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Albumin ratio (tissue/plasma)-PT" id="849" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Vf (water)-PT" id="850" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Fraction interstitial" id="851" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Vf (neutral lipid)-WS" id="852" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Vf (neutral lipid)-RR" id="853" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Vf (neutral phospholipid)-RR" id="854" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Vf (neutral phospholipid, plasma)-WS" id="855" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Vf (extracellular water)-RR" id="856" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Vf (protein)-WS" id="857" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Vf (water)-WS" id="858" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Vf (intracellular water)-RR" id="859" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Vf (acidic phospholipids)-WS" id="860" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Acidic phospholipids [mg/g] - RR" id="861" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Density (tissue)" id="862" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Fraction of blood for sampling" id="863" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Fraction mucosa" id="864" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Fraction of regional blood flow rate" id="865" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Flow fraction via large pores" id="866" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Radius (small pores)" id="867" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Hydraulic conductivity" id="868" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Radius (large pores)" id="869" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Vf (neutral lipid)-PT" id="870" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Vf (lipid)" id="871" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Fraction vascular" id="872" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Vf (phospholipid)-PT" id="873" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Vf (protein)" id="874" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Albumin ratio (tissue/plasma)" id="875" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Lipoprotein ratio (tissue/plasma)" id="876" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Albumin ratio (tissue/plasma)-PT" id="877" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Vf (water)-PT" id="878" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Vf (water)" id="879" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Fraction interstitial" id="880" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Vf (neutral lipid)-WS" id="881" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Vf (neutral lipid)-RR" id="882" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Vf (neutral phospholipid)-RR" id="883" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Vf (neutral phospholipid, plasma)-WS" id="884" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Vf (protein)-WS" id="885" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Vf (extracellular water)-RR" id="886" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Vf (intracellular water)-RR" id="887" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Vf (water)-WS" id="888" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Vf (acidic phospholipids)-WS" id="889" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Acidic phospholipids [mg/g] - RR" id="890" />
-          <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|pH" id="891" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|pH" id="892" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|pH" id="893" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|pH" id="894" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|pH" id="895" />
-          <Map s="Organism|LargeIntestine|Large intestinal transit time|Percentile" id="896" />
-          <Map s="Organism|LargeIntestine|Large intestinal transit time|Mean" id="897" />
-          <Map s="Organism|LargeIntestine|Volume|Percentile" id="898" />
-          <Map s="Organism|LargeIntestine|Volume|Mean" id="899" />
-          <Map s="Organism|LargeIntestine|Volume|Deviation" id="900" />
-          <Map s="Organism|LargeIntestine|Specific blood flow rate|Percentile" id="901" />
-          <Map s="Organism|LargeIntestine|Specific blood flow rate|Mean" id="902" />
-          <Map s="Organism|LargeIntestine|Specific blood flow rate|Deviation" id="903" />
-          <Map s="Organism|LargeIntestine|Intracellular|pH" id="904" />
-          <Map s="Organism|LargeIntestine|Mucosa|Caecum|Density (tissue)" id="905" />
-          <Map s="Organism|LargeIntestine|Mucosa|Caecum|Fraction of blood for sampling" id="906" />
-          <Map s="Organism|LargeIntestine|Mucosa|Caecum|Fraction of regional blood flow rate" id="907" />
-          <Map s="Organism|LargeIntestine|Mucosa|Caecum|Fraction mucosa" id="908" />
-          <Map s="Organism|LargeIntestine|Mucosa|Caecum|Radius (small pores)" id="909" />
-          <Map s="Organism|LargeIntestine|Mucosa|Caecum|Flow fraction via large pores" id="910" />
-          <Map s="Organism|LargeIntestine|Mucosa|Caecum|Radius (large pores)" id="911" />
-          <Map s="Organism|LargeIntestine|Mucosa|Caecum|Hydraulic conductivity" id="912" />
-          <Map s="Organism|LargeIntestine|Mucosa|Caecum|Vf (neutral lipid)-PT" id="913" />
-          <Map s="Organism|LargeIntestine|Mucosa|Caecum|Vf (lipid)" id="914" />
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-          <Map s="Organism|Muscle|Vf (protein)|Percentile" id="1107" />
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-          <Map s="Organism|Muscle|Vf (water)|Percentile" id="1113" />
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-          <Map s="Organism|Muscle|Vf (water)-WS|Mean" id="1130" />
-          <Map s="Organism|Muscle|Specific blood flow rate|Percentile" id="1131" />
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-            <Parameter id="JYNm6p3QHUK3EHKOUPLAKQ" name="Start time" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" visible="1" canBeVaried="0" value="120" displayUnit="h" />
-            <Parameter id="Yc1FxlJwR0KmPGR3QmN-jA" name="End time" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" visible="1" canBeVaried="0" value="1440" displayUnit="h" />
-            <Parameter id="cVnqNzRI7Ee0ptCRXZLgOg" name="Resolution" persistable="0" isFixedValue="0" dim="Resolution" quantityType="Parameter" visible="1" canBeVaried="0" value="0.0666666666666667" displayUnit="pts/h" />
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-        </OutputInterval>
-      </Children>
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-  </SimulationConfiguration>
-  <Model id="g-CMx_X9L0CI09ne49pmmQ" name="S1" neighborhoods="V7TJXYjt90mBVdEJTRXTZA">
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-      <Tags>
-        <Tag value="RootContainer" />
-      </Tags>
-      <Children>
-        <Container id="8Ork3SAttkSAzdfhZm_wPg" name="Organism" description="Organism" icon="Organism" mode="Logical" containerType="Organism">
-          <Children>
-            <Parameter id="-1HC_uqRDUajkLQYxxSbKQ" name="Specific clearance (endosome)" description="Specific endosomal clearance" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="7f7I-J0rpk6iunymmUMR2w" visible="1" canBeVaried="1" displayUnit="1/min" />
-            <Parameter id="g7xXcjpJekinrn_UT2wxvA" name="SA proportionality factor" description="Proportionality factor for the surface area plasma &lt;=&gt; int" persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" visible="0" canBeVaried="1" value="9500" displayUnit="1/cm" />
-            <Parameter id="ABEeDJJlyUGd_E_r_YosDg" name="Volume (plasma)" description="Whole body plasma volume" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="t8Cs26aQRUy_kEVOA3nTkQ" visible="0" canBeVaried="0" displayUnit="l" />
-            <Parameter id="w9GYFlv4YkWWaWMIUpFv4Q" name="Surface area scaling exponent" description="Global shape parameter; used (as exponent) for calculating diffusion stream between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-            <Parameter id="4twvzuwuEUCpVU2IAwR5Rw" name="Weight" description="Body weight" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="5NfeZWwmw0GljuJMF9i5Xg" visible="1" canBeVaried="1" displayUnit="kg" />
-            <Parameter id="Akedi9owJ0e7BQmUOrObog" name="Estimated gestational age" description="Estimated gestational age" persistable="0" isFixedValue="0" dim="Age in weeks" quantityType="Parameter" formula="CckOeL5hIk6w2FqbJnQpzA" visible="0" canBeVaried="1" displayUnit="week(s)" />
-            <Parameter id="Qvc3WWn55UGkICllorWOcQ" name="BMI" description="Body mass index" persistable="0" isFixedValue="0" dim="BMI" quantityType="Parameter" formula="vERT48h6FkqUlnkWGPKRBA" visible="1" canBeVaried="1" displayUnit="kg/m²" />
-            <Parameter id="m6RDZ3-qsEapYq-Fq3oEGA" name="Vf (neutral lipid, blood cells)-WS" description="Fractional volume content of neutral lipid in blood cells used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.003" />
-            <Parameter id="zLube9RpAUyhAG5InheVHw" name="Vf (water,plasma)" description="Fractional volume content of water in plasma used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.926" />
-            <Parameter id="wi2CwUl0WUWfgdtghgc-Uw" name="Vf (water,interstitial)" description="Fractional volume content of water in interstitial space used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.935" />
-            <Parameter id="AkxlzEjXJUquK6RkSN0i_g" name="Vf (water,blood cells)" description="Fractional volume content of water in blood cells used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.625" />
-            <Parameter id="9x4jwzhnz0mMqo_8ZPGKtA" name="Vf (protein,plasma)" description="Fractional volume content of protein in plasma used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.067" />
-            <Parameter id="r0ew8eBzo0ukwJGYaugRVg" name="Vf (protein,blood cells)" description="Fractional volume content of protein in blood cells used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.325" />
-            <Parameter id="FWduD_gQlUG3AaCwHgJaTg" name="Protein ratio (interstial/plasma)" description="The ratio between the protein volume fraction in interstitial space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.37" />
-            <Parameter id="SZZ5Invm6EKaZgZsoGf6OQ" name="Vf (lipid, blood cells)" description="Fractional volume content of lipid in blood cells" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.005" />
-            <Parameter id="Eqxn_rbNz0efs5abnUFxzQ" name="Vf (lipid, plasma)" description="Fractional volume content of lipid in plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.007" />
-            <Parameter id="P-1iTDzEU0e512ILMD-MFg" name="Vf (neutral lipid, plasma)-RR" description="Fractional volume content of neutral lipid in plasma used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0032" />
-            <Parameter id="mxCkp1xy6kSseKkOitohAg" name="Thickness (endothelium)" description="Thickness of vascular endothelium" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="3E-06" displayUnit="cm" />
-            <Parameter id="2IIUDdU890avKzBYZFa0hA" name="pH (plasma)" description="pH of plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.4" />
-            <Parameter id="zZ8SDmlBs0ufvPyJv6oIGA" name="pH (blood cells)" description="Intracellular pH of blood cells" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.22" />
-            <Parameter id="bOWjAb1T906rm-GHo6SetQ" name="pH (interstitial)" description="pH of interstitial space" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.4" />
-            <Parameter id="ydTn5OhivEudtDGDovYD1g" name="pH (intracellular)" description="pH of intracellular space" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7" />
-            <Parameter id="SYVETSLh-0O7Jll-iRlwdQ" name="R*T" description="Gas constant-body temperature product (37°C)" persistable="0" isFixedValue="0" dim="RT" quantityType="Parameter" visible="1" canBeVaried="0" value="928.8" displayUnit="N*cm/mol" />
-            <Parameter id="cb1ckdy5wUSpI5TgBFU6yQ" name="Na" description="Avogadro constant" persistable="0" isFixedValue="0" dim="Inversed mol" quantityType="Parameter" visible="0" canBeVaried="0" value="6.022E+17" displayUnit="1/mol" />
-            <Parameter id="IDZlPad8AkmFrLrL_5L0Pg" name="Gestational age" description="Gestational age" persistable="0" isFixedValue="0" dim="Age in weeks" quantityType="Parameter" visible="1" canBeVaried="1" value="40" displayUnit="week(s)" />
-            <Parameter id="7e_jYxnF50yw0yefyy0sbA" name="Age" description="Age" persistable="0" isFixedValue="0" dim="Age in years" quantityType="Parameter" visible="1" canBeVaried="1" value="30" displayUnit="year(s)" />
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-            <Parameter id="jqsPwTPS1EmXMfZOyPpiTw" name="Vf (neutral lipid, plasma)-PT" description="Fractional volume content of neutral lipid in plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0035" />
-            <Parameter id="t1zO4BLgNkq_h3PSNazJTg" name="Vf (neutral phospholipid, blood cells)-WS" description="Fractional volume content of neutral phospholipid in blood cells used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0059" />
-            <Parameter id="zWvREZ5dpES00eKl2upI3w" name="Vf (neutral phospholipid, plasma)-RR" description="Fractional volume content of neutral phospholipid in plasma used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0021" />
-            <Parameter id="FTVVgKvPNE23JIFLQTTi7w" name="Surface/Volume ratio (blood cells)" description="Surface area to volume ratio of blood cells" persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" visible="0" canBeVaried="1" value="167000" displayUnit="1/cm" />
-            <Parameter id="QqwoG6640EWSAxegwWgFrg" name="Vf (phospholipid, plasma)-PT" description="Fractional volume content of phospholipid in plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.00225" />
-            <Parameter id="zqqpbJq5RkOEZYbfxdtZNQ" name="Vf (acidic phospholipids, blood cells)-WS" description="Fractional volume content of acidic phospholipid in blood cells used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.001" />
-            <Parameter id="cU1_ZLpSAUe7AMa33iP9wQ" name="Vf (neutral lipid, blood cells)-RR" description="Fractional volume content of neutral lipid in blood cells used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0012" />
-            <Parameter id="6O0xJczfqU2wHZx8PEZi9g" name="Plasma protein scale factor" description="Scale factor for the fraction unbound in plasma. This factor can be used if changes in the plasma protein concentration and, as a result, in the plasma protein binding of the drug are expected due to e.g. ageing or certain diseases such as cirrhosis, sepsis, or renal failure" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="1" />
-            <Parameter id="ruPSHmt1j0iXpKHdvxo1vw" name="Fraction of endosomal uptake from plasma (global)" description="Fraction of drug uptake from plasma into endosomal space relative to total uptake from plasma and interstitial space" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-            <Parameter id="Lnzti5Jxdkq4Fj02hDGmeA" name="Ontogeny factor (alpha1-acid glycoprotein)" description="Ontogeny factor (α1-acid glycoprotein)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-            <Parameter id="dBJxYoeiUEKQ1v3s4-eI0Q" name="Ontogeny factor (albumin)" description="Ontogeny factor (albumin)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-            <Parameter id="AomGEEKMTk2tzhzBJxjm4A" name="Height" description="Body height" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="16.996" displayUnit="cm" />
-            <Parameter id="KsYSbKAlu0iDu0NWc1lx2Q" name="Vf (neutral phospholipid, blood cells)-RR" description="Fractional volume content of neutral phospholipid in blood cells used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0033" />
-            <Parameter id="eoHYeZl2Gke2i_2QxvSEAA" name="Vf (water,plasma)-PT" description="Fractional volume content of water in plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.945" />
-            <Parameter id="CpgL_qFWU0OL_dSmkRHkJQ" name="Acidic phospholipids (blood cells) [mg/g] - RR" description="Concentration of acidic phospholipids in red blood cells [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.57" />
-            <Parameter id="TF2UUOC9CkOMCztlYJhSsg" name="Fraction recycled to plasma (global)" description="Fraction of drug recycling to plasma relative to total recycling to plasma and interstitial space" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-            <Parameter id="8kVQvY_pKUmNpt_JBRRMXA" name="Vf (intracellular water, blood cells)-RR" description="Fractional volume content of intracellular water in blood cells used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.63" />
-            <Parameter id="q9pgUdHjLEWCzhjRfdioIw" name="Rate constant for endosomal uptake (global)" description="Rate constant for endosomal uptake for all organs" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" visible="1" canBeVaried="1" value="0.36" displayUnit="1/min" />
-            <Parameter id="_iC06AJAtUqKjxbhADtEFA" name="Rate constant for recycling from endosomal space (global)" description="Rate constant for recycling from endosomal space for all organs" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" visible="1" canBeVaried="1" value="0.083" displayUnit="1/min" />
-            <DistributedParameter id="yXG6xBQRk0CGLBtApbvxAQ" name="Hematocrit" description="Hematocrit" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="zVlcxA1tz0qpGRMB2puRdw" mode="Logical" visible="1">
-              <Children>
-                <Parameter id="t4tX2ZpGmE6PDqUNMXv0GQ" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                <Parameter id="zXB_tDHJ_k-H6-BVF14h7w" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.47" />
-              </Children>
-            </DistributedParameter>
-            <DistributedParameter id="rNO8CtwwBkmztzzNuJryyA" name="MeanBW" description="Weight" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="cq6wpMJuDkygXmj8eKHVlA" mode="Logical" visible="0" displayUnit="kg">
-              <Children>
-                <Parameter id="EBUkP2qzukSmorqpLDzwNA" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" displayUnit="kg" />
-                <Parameter id="l1f6xadDTEWL1w9uwHr9OQ" name="Mean" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" visible="0" canBeVaried="1" value="60.034" displayUnit="kg" />
-                <Parameter id="gGx5Emp0CUiB6NFZhEBBlw" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" visible="0" canBeVaried="1" value="3.0017" displayUnit="kg" />
-              </Children>
-            </DistributedParameter>
-            <DistributedParameter id="zdD3Byo5uEqnh-cUvwqJ8g" name="MeanHeight" description="Height" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="Qlb0a7jM60mg0lWabVrflw" mode="Logical" visible="0" displayUnit="cm">
-              <Children>
-                <Parameter id="aDVft0wucE6P4SSBB6xoiw" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" displayUnit="cm" />
-                <Parameter id="-rYdRopSk0G8zYftVgD_hg" name="Mean" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="16.996" displayUnit="cm" />
-                <Parameter id="0NSkmgnHHE2HkVOfk9E0jg" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.59486" displayUnit="cm" />
-              </Children>
-            </DistributedParameter>
-            <Container id="uAdUCVBBYUS3299aaPW3gg" name="PeripheralVenousBlood" description="Peripheral Venous Blood" icon="VenousBlood" mode="Logical" containerType="Organ">
-              <Children>
-                <Container id="cTUAkJl7s0CVElr-8d0lPQ" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Observer id="8iRjFSeZD0iH6_RD8YyXxA" name="Blood Cells" description="Blood Cells" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="BsdRILXOJEi3B9i7jlk4nA" displayUnit="µmol/l" />
-                    <Observer id="LQKnRD3x2ESzfrZGy3OF4w" name="Plasma (Peripheral Venous Blood)" description="Plasma" persistable="1" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="Ij1MCjGQykmVi70pU6OOhA" displayUnit="µmol/l" />
-                    <Observer id="0FSVs6yg5k2bnXKd-gfUqg" name="Plasma Unbound (Peripheral Venous Blood)" description="Plasma Unbound" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="3vxW0wxpG0ivBd-ifK86ZQ" displayUnit="µmol/l" />
-                    <Observer id="KqggQ3SI-EWT11mVD_iomw" name="Whole Blood (Peripheral Venous Blood)" description="Whole Blood" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="3Le0qdHJZUCGNRv0a1ic3A" displayUnit="µmol/l" />
-                  </Children>
-                </Container>
-              </Children>
-            </Container>
-            <Container id="nMPjSz4Fkk6bNFLBHJyh6g" name="VenousBlood" description="VenousBlood" icon="VenousBlood" mode="Logical" containerType="Organ">
-              <Tags>
-                <Tag value="BloodOrgan" />
-              </Tags>
-              <Children>
-                <Parameter id="5V1YiE1NoECQyFUoNMV1QQ" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="uSjt8LuoBUu75Z4-7ZUOCw" visible="0" canBeVaried="1" displayUnit="kg" />
-                <Parameter id="Nbktz9Qh7kaQ0jqrrjP9Bg" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                <Parameter id="aJ5FLg9mCUy7uhjvi3xL4A" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="0" value="0.75" />
-                <Parameter id="Qx5VxTih6kmUw090GAcSRw" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="1" />
-                <DistributedParameter id="HVx1rqsQX0qdioAS85mddA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="j9Y1O-XvkEWhRHVXNDELaQ" mode="Logical" visible="1" displayUnit="l">
-                  <Children>
-                    <Parameter id="aFhvXcSb30aaCYN9BSCMWw" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.501140854040494" displayUnit="l" />
-                    <Parameter id="m2JR5LWh1UeavI1eq8JmIg" name="Mean" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" value="0.776531873" displayUnit="l" />
-                    <Parameter id="E4UmoxpUsESkYr-uXjXYAw" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" value="0.038826594" displayUnit="l" />
-                  </Children>
-                </DistributedParameter>
-                <Container id="J2AzZMiPQUibGWyUqz4XLA" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="BloodOrgan" />
-                    <Tag value="VenousBlood" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="5Hhhe_mTC0quX-4Wq4tjoQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="PnEwytfbw0yZn_t7q9ukhw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="InNrdVCgRUCPod7Jj5RRRw" visible="1" canBeVaried="1" displayUnit="l" />
-                    <MoleculeAmount id="B3lPdr5IY0uIYf2oKyowmg" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                      <Children>
-                        <Parameter id="uZT0aD6CZkOCoanuRMTSLg" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                        <Parameter id="f3alCCVOJU6JId_EHdf82w" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="w49ejkDxfUq_1gOfF3GGCg" visible="0" canBeVaried="0" />
-                        <Observer id="WGTR8LRHdkGpvxxl0kKaTw" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
-                        <Observer id="M8U2RqEY9kmLcTX-Dae5Bw" name="Plasma Unbound" description="Plasma Unbound" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="YJ3uKXnk6UyCmv-525r6ig" displayUnit="µmol/l" />
-                      </Children>
-                    </MoleculeAmount>
-                  </Children>
-                </Container>
-                <Container id="HLhY21FI2UuJWgRMTu6RlA" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="BloodOrgan" />
-                    <Tag value="VenousBlood" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="Cr1RH5B4ZECdes_sjkNQcw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="c-4YDDRjEEaRS-idWwrbtg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="L6CtLSeqU0O1dIF8kt2LDQ" visible="1" canBeVaried="1" displayUnit="l" />
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-                        <Observer id="rOgsO0a0lE-gKnDiFpi8ZQ" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
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-              <Tags>
-                <Tag value="BloodOrgan" />
-              </Tags>
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-                <Parameter id="nToOPT3YrUCjoUBG0P1FeQ" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="uSjt8LuoBUu75Z4-7ZUOCw" visible="0" canBeVaried="1" displayUnit="kg" />
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-                <Parameter id="WdYxVyYO_0S7YweZhm2rVw" name="Peripheral blood flow fraction" description="Blood flow fraction in organ used for calculation of peripheral venous blood concentrations" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" visible="1" canBeVaried="1" value="0" />
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-                    <Parameter id="025xHahZG0CFVnpnx6jQ1Q" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.500575515426459" displayUnit="l" />
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-                    <Parameter id="RCKG3gMg9EadJUKUzVUqwg" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" value="0.016881128" displayUnit="l" />
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-                <Container id="qJqHlxhje0erBO7-fTj4-g" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
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-                    <Tag value="ArterialBlood" />
-                    <Tag value="BloodOrgan" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="qxKRuAEDYUOsSE8rHaDM_Q" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="65W70d9dn0Ov0ppulho8MQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="InNrdVCgRUCPod7Jj5RRRw" visible="1" canBeVaried="1" displayUnit="l" />
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-                        <Parameter id="4Fwq0e4RWk6DOCJsZTnI1A" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
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-                        <Observer id="eQOn3CGkkECakd8Sy8iTwA" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
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-                <Container id="0_QXjFTwnEy8-V1CtkHsew" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="ArterialBlood" />
-                    <Tag value="BloodOrgan" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="JfOpWNMEJUOoXfk1coPjdQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="qRQ5lrDxGE6WKsxHonLURQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="L6CtLSeqU0O1dIF8kt2LDQ" visible="1" canBeVaried="1" displayUnit="l" />
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-                        <Observer id="DTf3zEdAXkOaroieQV6JWw" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
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-                <Container id="vl7QJ_Ocd0W4-fU-nvIxpg" name="C1" mode="Logical" containerType="Molecule">
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-            <Container id="4wG1HdnR90upld7ARMVVbw" name="Gallbladder" description="Bile compartment used to collect excretion to the bile" mode="Physical" containerType="Organ">
-              <Tags>
-                <Tag value="Liver" />
-              </Tags>
-              <Children>
-                <Parameter id="znab6r5aS0qlpi4B-XG63A" name="Gallbladder emptying rate" description="Rate of gallbladder emptying" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" visible="0" canBeVaried="0" value="0" displayUnit="µmol/min" />
-                <Parameter id="R_Mj8gC-o0Gt3T1fukDhAw" name="Time to complete gallbladder refilling" description="Time to complete gallbladder refilling" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" formula="1GMLpkWw_0qAQitMgQPb3A" visible="1" canBeVaried="1" displayUnit="min" />
-                <Parameter id="ZCNv7lgpcEmmrWAQf5vFrw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="l" />
-                <Parameter id="I0KQZkrkvU-0G25F5-gCMA" name="Gallbladder ejection half-time" description="Gallbladder ejection half-time" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" visible="1" canBeVaried="1" value="19.7" displayUnit="min" />
-                <Parameter id="SdhHOZ19nkSqR7xk6i_F6w" name="Gallbladder ejection fraction" description="Gallbladder ejection fraction" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" visible="1" canBeVaried="1" value="0.65" />
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-                  <Children>
-                    <Parameter id="DtkfaXieC0qpqzB-2kbAAQ" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                    <Observer id="IZShU5DpCUOz5b8IYJ7BzQ" name="Fraction excreted to bile" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Drug, Observer" formula="ucqtSba9z0qGMpkWbb5ibw" />
-                  </Children>
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-            <Container id="4qdUEY72nUW06pp8zN8ImQ" name="Bone" description="Bone" icon="Bone" mode="Logical" containerType="Organ">
-              <Tags>
-                <Tag value="TissueOrgan" />
-              </Tags>
-              <Children>
-                <Parameter id="7zsvW_V50UiHjVMWtUXBXA" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="uSjt8LuoBUu75Z4-7ZUOCw" visible="0" canBeVaried="1" displayUnit="kg" />
-                <Parameter id="RzqxI4S6yEu0U5s4m8o2WQ" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="jdhhCNoMYE-s118HG9XzZw" visible="1" canBeVaried="1" displayUnit="l/min" />
-                <Parameter id="p0mbRkvRFUqOBfsoMdROIA" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="-cxwem1NiE-a_jAGvZjliw" visible="1" canBeVaried="1" displayUnit="l/min" />
-                <Parameter id="hxQSxU0M8U2lZlzx14BIkw" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="eWgukotC9UOd9gIjHiEAoQ" visible="1" canBeVaried="1" displayUnit="l/min" />
-                <Parameter id="OQNR4EwtlUazZWSgKcL8EQ" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="jmk0yzYrokibtBSuCCVMag" visible="1" canBeVaried="0" displayUnit="l" />
-                <Parameter id="cJ9m1x8ZA0OdYWK574nIAg" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="LSHvGCmOBEascdPo-Ab-KQ" visible="1" canBeVaried="1" />
-                <Parameter id="JlQ-YjggVUiCGh2-wpkRnA" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                <Parameter id="NMQm9_gd30i7enLTTifBYw" name="Peripheral blood flow fraction" description="Blood flow fraction in organ used for calculation of peripheral venous blood concentrations" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" visible="1" canBeVaried="1" value="0" />
-                <Parameter id="4bsnVmIf5k2yPkjxr0fnmw" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="2" />
-                <Parameter id="NG3dlbiRY0CLtPsYZlae-w" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                <Parameter id="UPlgdv16O0GwKuO0XVS_GA" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.8" />
-                <Parameter id="t2hodwKZ5k6Uto6engfV7g" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="3.3E-07" displayUnit="µm" />
-                <Parameter id="R4ZlyWEHYkmH_9w-AA_j9w" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="9E-08" displayUnit="µm" />
-                <Parameter id="k80VC0f-hEm78LS5xnZz3Q" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" visible="1" canBeVaried="1" value="3.88888888888889E-11" displayUnit="ml/min/N" />
-                <Parameter id="TvdlgkgEBk-nX92JAPvE7w" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.074" />
-                <Parameter id="AZSSvd3-yk2PzGyq63SkkA" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.268" />
-                <Parameter id="I9ND76YGKU2noUkE5jgLaA" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.034" />
-                <Parameter id="Pyoy7n_bnkSy2zRv_9hoyg" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.268" />
-                <Parameter id="RPeSxhN8WUux1o-VeoqRhQ" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0011" />
-                <Parameter id="yVJ_RRj8bU2-KyV1QneUVw" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.1" />
-                <Parameter id="TyBpXx0jwUaMmN_NkZZiSA" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.05" />
-                <Parameter id="GZkfZPHEn061EpFFHIL4ZA" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.465" />
-                <Parameter id="rRLPKe_AVE6YACYgsBZfOw" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.439" />
-                <Parameter id="q54PanPSXEeR3-PIo1t7pQ" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-                <Parameter id="WCGZp1pPhUSx5sKUM-WmhQ" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.1" />
-                <Parameter id="oQdMsBt2TUO9UrBgcccb8Q" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.017" />
-                <Parameter id="J-nVvbe9akiJZ8HBGINJSw" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0174" />
-                <Parameter id="bckPpNjIX0WAobE46U3ZZQ" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0016" />
-                <Parameter id="C4FIMhvTPEaAYavRo6QZVA" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0022" />
-                <Parameter id="cyuUl3Cc0Eux8EYYvR9nmw" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.1" />
-                <Parameter id="pTTZ-wSLQEK3vs-xY2yiKw" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.21" />
-                <Parameter id="uzuQIqqPpUOzW_BduQe23g" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.26" />
-                <Parameter id="0HpNx9c7m0al2jbqJ-WAeg" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.317" />
-                <Parameter id="ieP-jT32b0ink-P0CPxY9w" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0008" />
-                <Parameter id="W5BpNeXI9UeoMkV4H9q8eg" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.67" />
-                <DistributedParameter id="LWrFfeDonUKNGmMlFrclBw" name="Specific blood flow rate" description="Blood flow rate normalized to the organ volume" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" formula="zRSH7L9toEyUpMn9VXV4XA" mode="Logical" visible="1" displayUnit="ml/min/100g organ">
-                  <Children>
-                    <Parameter id="nZJo8AuCdE6B9LN77Qeu9w" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" displayUnit="ml/min/100g organ" />
-                    <Parameter id="gk23FlzhhkWn0we8Zy8TKQ" name="Mean" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" visible="0" canBeVaried="1" value="0.027495" displayUnit="ml/min/100g organ" />
-                    <Parameter id="vHmRCxYub0CEzOIUnY37GA" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" visible="0" canBeVaried="1" value="0.00137475" displayUnit="ml/min/100g organ" />
-                  </Children>
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-                <DistributedParameter id="8Et6rgzvw0KdBt3Zdz2hkg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="C4PTeR4kgEq8Xv5Os0D8ig" mode="Logical" visible="1" displayUnit="l">
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-                        <Parameter id="vswFyIEvJUSk-AYMGgvXFw" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
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-                        <Parameter id="XV9yqXXaak6tOWuvhZFxjg" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
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-                        <Parameter id="nhQpp0a4uEifJfRqFDRrxA" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" displayUnit="min" />
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-                      </Children>
-                    </DistributedParameter>
-                    <DistributedParameter id="R6NaO0OrGEmTpHMZmUWcqQ" name="Distal radius" description="Distal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="B53L7nlq7Um8XOQEISxFMw" mode="Logical" visible="1" displayUnit="cm">
-                      <Children>
-                        <Parameter id="LZblFdkSf0-9xN6b1fJb5g" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" displayUnit="cm" />
-                        <Parameter id="J9bNMSiUJ0yrTZyzVvADFQ" name="Mean" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" displayUnit="cm" />
-                      </Children>
-                    </DistributedParameter>
-                    <DistributedParameter id="aBrJv457nkq9Fa1qp3wpkw" name="Proximal radius" description="Proximal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="BmdXwW_s8kKHYzdcdlIW5w" mode="Logical" visible="1" displayUnit="cm">
-                      <Children>
-                        <Parameter id="oBrncsH65kyl_e7_qsFnDA" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" displayUnit="cm" />
-                        <Parameter id="T3-xRRycJ0arhZLdsVotwg" name="Mean" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" displayUnit="cm" />
-                      </Children>
-                    </DistributedParameter>
-                    <MoleculeAmount id="r-aj2d-zBEqErgcKF5e5cw" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                      <Children>
-                        <Parameter id="sjeLhSK910eNTqktjITt6Q" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                        <Parameter id="gds4uuWev0WXmvDk1pcqNQ" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="tFRuG0BcTkCfp1lGzxb4_w" visible="0" canBeVaried="0" />
-                        <Parameter id="YVYRmiMxbU62uLTxpGGAlg" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CtoZxtyF40G6mU1E-C-gbw" visible="0" canBeVaried="0" />
-                        <Parameter id="XApZINsiykequ45fXxqNpQ" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="6howmnSOgUWoFvUztoZc-Q" visible="0" canBeVaried="0" />
-                        <Parameter id="m7L1bwpDC0GCP3Vs80d_Pg" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="gzVX_eoL6keY2BTr5In6CA" visible="0" canBeVaried="0" />
-                        <Parameter id="r-qbMYuBK0uH90zlGPZM7A" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="nh1QP8zoc0aCA5Ws4ObUFw" visible="0" canBeVaried="0" />
-                        <Parameter id="kVJesrNp5EKWrkpyYBvVKQ" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="HJBcErCLskqfcphqybq56w" visible="0" canBeVaried="0" />
-                        <Parameter id="gMCf54hcSkOnzNkp8b8w2g" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="0" value="1" />
-                        <Parameter id="hgXq6C-oQUi6TntciXFGxw" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="yYgpb2Q5SUy9FpSvv43UuQ" visible="0" canBeVaried="0" />
-                        <Parameter id="-4rS7V0AF0y_7DbLvjk6HA" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="dz2W8TF89Uaa7HOFFKblsg" visible="0" canBeVaried="0" />
-                        <Parameter id="kTo5cw0aS0unQMuAiDwJcA" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="xt6XFpUK6UqEqNbzoeBKKw" visible="0" canBeVaried="0" />
-                        <Parameter id="lNaCzrCShkOAoue4QPpKyw" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="ctJprO9AWUmtVkiYBwY72w" visible="0" canBeVaried="0" />
-                        <Parameter id="bDdoay6JJ0qtDHj6XxH23w" name="Solubility" description="Solubility" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" formula="mt08mwG6SE2z1uRWJcFFtA" visible="1" canBeVaried="1" displayUnit="mg/l" />
-                        <Parameter id="LSZwssxW7EGw2VzrgcXC8A" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="dhSNVrIzyEeZMSU6Uku8pQ" visible="0" canBeVaried="0" />
-                        <Parameter id="PSMnLVeTJEm9M8pgfvjhUw" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="aXc6LrjtKU6OCw_2wa_kjA" visible="0" canBeVaried="0" />
-                        <Observer id="Ypa5V9mecE24TK19BtSWTA" name="Concentration in lumen" description="Concentration of the molecule in lumen" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="HLIRXIitt0KZivKUJbxfRQ" displayUnit="µmol/l" />
-                      </Children>
-                    </MoleculeAmount>
-                  </Children>
-                </Container>
-                <Container id="RBDgGJ__rUCEJi-Z5h0eyg" name="Duodenum" description="Duodenum" icon="Duodenum" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Lumen" />
-                    <Tag value="LumenSegment" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="huSe05o9YEq6Ji-bTG3y5g" name="Proximal radius" description="Proximal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="qXWNXa9UNUq30PzJeA1etg" visible="1" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="RJKk2XDR602B1L-LMHi8Mw" name="Absorption of liquid" description="rate of liquid outflow" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="Cx7CJ5pXtkmQE3THHwSZ7g" visible="0" canBeVaried="1" displayUnit="1/min" />
-                    <Parameter id="q1d-RJRmDEOzr6mMQ6vUHw" name="Distal radius" description="Distal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="F2HrUeP5gUqsHUmUBhdDeQ" visible="1" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="Fhi20MtVykCfIdn6m4aU4A" name="FillLevelFlag" description="Fill Level Flag" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="_fdpBznEC02u7-tLvw5OGQ" visible="0" canBeVaried="1" />
-                    <Parameter id="QY1Skpw6IUWaLs3nBNJqlA" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="OyHn7MCeuk6vmTKdv-iJqA" visible="0" canBeVaried="1" />
-                    <Parameter id="P2S3VADNPESCj5X5-5eoUg" name="Geometric surface area" description="Geometric surface area of GI segment" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="9EhmHSAXZ0OXYPaSstfWrQ" visible="1" canBeVaried="1" displayUnit="cm²" />
-                    <Parameter id="hHa16HzMWUKDbuWymUnnHA" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="_qO40oypYEe7o9c_axohhQ" visible="0" canBeVaried="1" displayUnit="1/min" />
-                    <Parameter id="4sLgVBCl0kmDbkj5mcCAEA" name="Length" description="Length" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="oHVl-7jv2UWh9dAin2b_Tg" visible="1" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="BY-qnHfoFEepophDxls1ew" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="FYt0XM3NSEm1olbz1Ry5NQ" visible="0" canBeVaried="0" displayUnit="l/min" />
-                    <Parameter id="e22mFA7WlEeLBdSPSXLScw" name="Secretion of liquid" description="Rate of liquid inflow" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="ksD8HjZp7E-n2zdTsbRDHA" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="xXWuHkk77k6CMJcXDN92-A" name="Thickness of gut wall" description="Thickness of Gut Wall" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="PqZQXUcR2EuAADd5-fG5VQ" visible="0" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="nKrC_OaJIEmeejGIxDfD9A" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="cXeVNOGhxUGjgGD8PwjALA" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Parameter id="RKf_ZaFtwkSYaMqz1os5Gg" name="Volume (gut wall)" description="Volume of the gut wall" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="be4QsJfPPUGwk2ypJjVq4A" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Parameter id="maPARwUURkyQp3XkfCxeSQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="w_dZx0XeNEK2FQrue6H__w" name="Liquid" description="Liquid" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="2aVY-_-FqE6bH8tHqQryGA" visible="0" canBeVaried="1" rHSFormula="ILdSr3WmXkGlGKLVHvMX0g" displayUnit="l" />
-                    <Parameter id="BjDua42Hv0KpBOxKguqIuA" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="6" />
-                    <Parameter id="pm7zcCD7YUCpkW7i_7FL_Q" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.30705627" displayUnit="1/cm" />
-                    <Parameter id="x4uDVqMxWUmoFrzibcrIVg" name="Microvilli factor" description="Microvilli factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="25" />
-                    <Parameter id="gayL4QEe80KprNxz2V9TwA" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0186500479" displayUnit="cm" />
-                    <Parameter id="LPxNc35mrk6OB99EGwRM6Q" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.00925874" />
-                    <Parameter id="8bSFS_F3-0iax8POib1qiA" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0020705161" displayUnit="cm" />
-                    <Parameter id="g32WEFKnQUWNOwq-ZAKznw" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.010126747" />
-                    <Parameter id="7eaxTEJlq02SQYm8nJalMQ" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.002264627" displayUnit="cm" />
-                    <Parameter id="VxTqN_t1ikazmDwxQ13bTA" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.129622362" />
-                    <Parameter id="5_YiQC0IwUyVrYmPSfXXAg" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0289872252" displayUnit="cm" />
-                    <Parameter id="e5hLKcaosUmyqoGRj2QBiQ" name="Intestinal transit rate" description="Transit rate along intestinal segments" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" visible="0" canBeVaried="1" value="116" displayUnit="1/min" />
-                    <Parameter id="RI-YqGTMcUqDswileBLENg" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" visible="1" canBeVaried="1" value="0.06" />
-                    <Parameter id="1U6KzQEV5kavl0jE_zDccg" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0441002752" displayUnit="cm" />
-                    <DistributedParameter id="g7sv8X4c5k2UNIX3AvrJTA" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="INm5zP7fO0mY7KB-PiCiAg" mode="Logical" visible="1">
-                      <Children>
-                        <Parameter id="dQspryiGD0GN-R9o1BGbiQ" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                        <Parameter id="Y1HAe2mDpU6VinyabJB-yg" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="292.6883" />
-                      </Children>
-                    </DistributedParameter>
-                    <MoleculeAmount id="BaeHcf6VhUyw3ftOPt1iIg" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                      <Children>
-                        <Parameter id="7SaAhm76jE-TyiZyOfpUkA" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                        <Parameter id="FrfKmD2bvk-5Qv0AGe2KWg" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" visible="0" canBeVaried="0" rHSFormula="niCn2d8txEa2qSPLy3LZVQ" value="0" displayUnit="µmol" />
-                        <Parameter id="1WuKt0IOoEey86rW_uQTFA" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Dx-_lNC_PUi5tg4i5PXTKQ" visible="0" canBeVaried="0" />
-                        <Parameter id="rUbe0Mn8NUGo_n0ygXlhpA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="0" value="1" />
-                        <Parameter id="rpeaqlJIrUSQXnIjPoUoEg" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Dw_IyabHT06pZKMgIgZLug" visible="0" canBeVaried="0" />
-                        <Parameter id="36Y3rhK3fka6QB6Upl8kPg" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="PEGnAFSczUCFB1AD9gbV8g" visible="0" canBeVaried="0" />
-                        <Parameter id="kziKanoS60av1BC4t0ah0w" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="yG7za5lSzEy8vLZuU5wkUA" visible="0" canBeVaried="0" />
-                        <Parameter id="VvZ4ygrXoECQkbSSLmI2_w" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="7Ye2AKRBIEKHQosH1BcrAw" visible="0" canBeVaried="0" />
-                        <Parameter id="xdmQBvr6iEWh85nsZCc56w" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="1Km_ykFAmky-QhH3kd16xQ" visible="0" canBeVaried="0" />
-                        <Parameter id="wqZbpwqLiEmqQwZKKSsb7Q" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DKIYrF803UGNYCr8sb_Uqw" visible="0" canBeVaried="0" />
-                        <Parameter id="XsyB9bGMukiEH13F1tXgGQ" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="SDVkY49syEyB8z1yRYX0SQ" visible="0" canBeVaried="0" />
-                        <Parameter id="o8z19t5TDUWAj4dU8kHgiA" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="tnEtuIIrr0OBxbRFffEeog" visible="0" canBeVaried="0" />
-                        <Parameter id="bXHLTpbN6UCSXWNa_t5Zaw" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="ggY0rrsSrU-e3M7Gx9UwCw" visible="0" canBeVaried="0" />
-                        <Parameter id="KexqJbluG0SP3OkI7oVtIw" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="1MdvdFtFAEizb0iSLwDnZg" visible="0" canBeVaried="0" />
-                        <Parameter id="3UnqnJ17VEa6HWhZgEIfQA" name="Solubility" description="Solubility" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" formula="IX-iw63VFkG_5gjIvH9ADA" visible="1" canBeVaried="1" displayUnit="mg/l" />
-                        <Parameter id="lSkARzEBDEeBNgehh7YEJw" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="qq9-PdL5iEi2q4aukONsKw" visible="0" canBeVaried="0" />
-                        <Observer id="HVRaI8SaD0WT1aCODifQxw" name="Concentration in lumen" description="Concentration of the molecule in lumen" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="HLIRXIitt0KZivKUJbxfRQ" displayUnit="µmol/l" />
-                        <Observer id="oE1quVCYWkeycZQnaQjUhg" name="Fraction of oral drug mass absorbed into mucosa segment" description="Fraction of oral drug mass absorbed into mucosa segment" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Drug, Observer" formula="XKRnaHqlW0S6GDKupu_dRA" />
-                      </Children>
-                    </MoleculeAmount>
-                  </Children>
-                </Container>
-                <Container id="CiHSzBkCCUudCrF-9qgurw" name="UpperJejunum" description="Upper Jejunum" icon="UpperJejunum" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Lumen" />
-                    <Tag value="LumenSegment" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="PbQ-Gzo9XEGfBoi4ALS7lA" name="Geometric surface area" description="Geometric surface area of GI segment" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="9EhmHSAXZ0OXYPaSstfWrQ" visible="1" canBeVaried="1" displayUnit="cm²" />
-                    <Parameter id="vGvTxqRMaE-kp1UXdwg2kA" name="Length" description="Length" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="oHVl-7jv2UWh9dAin2b_Tg" visible="1" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="7im3zR7-HEa1XO48xsNQ5A" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="9cu0xtLbe0yJUIr_qTyTQg" visible="0" canBeVaried="0" displayUnit="l/min" />
-                    <Parameter id="_ndm5JUHa0yrdftumFBrLg" name="Proximal radius" description="Proximal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="qXWNXa9UNUq30PzJeA1etg" visible="1" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="QwxB7bkva0GNJaLjiKVh9w" name="Secretion of liquid" description="Rate of liquid inflow" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="aXkL7QBgEUG6QFMQYI5LUw" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="V4crhPoULU2Fgyg8IdBJow" name="Thickness of gut wall" description="Thickness of Gut Wall" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="PqZQXUcR2EuAADd5-fG5VQ" visible="0" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="4siWomwSlkiivpbmXkzQQg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="cXeVNOGhxUGjgGD8PwjALA" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Parameter id="OGjxBPEVNEOgpyAj3_klZg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="Gp0aFmBx7kKURGVxZAipYQ" name="Volume (gut wall)" description="Volume of the gut wall" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="cqhQCc4hw0OtUcRkOpcrTQ" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Parameter id="BEp5BmmESEmvekyg7xggpw" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="Noz4813aI0q6J4nYyCRNxw" visible="0" canBeVaried="1" displayUnit="1/min" />
-                    <Parameter id="48fixL4OlU6bxL6gUlq4Qw" name="Liquid" description="Liquid" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="2aVY-_-FqE6bH8tHqQryGA" visible="0" canBeVaried="1" rHSFormula="LegR7LtHwEm3PLkklvMuvw" displayUnit="l" />
-                    <Parameter id="rv1SFSDGG0CLcBZeEFEfPA" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="OyHn7MCeuk6vmTKdv-iJqA" visible="0" canBeVaried="1" />
-                    <Parameter id="FuqY6_nkLkSBBCOB9ygEbQ" name="Absorption of liquid" description="rate of liquid outflow" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="TEw4LQuM0UOCo4pEWNLLaw" visible="0" canBeVaried="1" displayUnit="1/min" />
-                    <Parameter id="BM8ic5FcikelXYUoHLWNgg" name="Distal radius" description="Distal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="F2HrUeP5gUqsHUmUBhdDeQ" visible="1" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="We6mamA88EKt4e-2RcG7PA" name="FillLevelFlag" description="Fill Level Flag" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="_fdpBznEC02u7-tLvw5OGQ" visible="0" canBeVaried="1" />
-                    <Parameter id="u75MvWDrJ0CmdcPd_PWYKQ" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="6.25" />
-                    <Parameter id="BpgfCYWmxkqcfhXfq0LQwQ" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.30703115" displayUnit="1/cm" />
-                    <Parameter id="SkH6juzWBUOddVd7d4uOVQ" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.299751712" />
-                    <Parameter id="h9jGd_VUCEqJFK26aFlhyw" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.00925874" />
-                    <Parameter id="yH4xFPp_7Eu9la02ERmqIQ" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0020705161" displayUnit="cm" />
-                    <Parameter id="51zp7QiTOUKMu6HfUQ4_Bg" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0670329582" displayUnit="cm" />
-                    <Parameter id="9dgOO-txAUuqrcQtoDK7oQ" name="Intestinal transit rate" description="Transit rate along intestinal segments" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" visible="0" canBeVaried="1" value="5.0162" displayUnit="1/min" />
-                    <Parameter id="TnDUOzycz0-mO9VuBAdCwA" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" visible="1" canBeVaried="1" value="0.064841" />
-                    <Parameter id="b30okq-_T0yljeVzWb7L7g" name="Microvilli factor" description="Microvilli factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="25" />
-                    <Parameter id="DpCIdmk3PEab_DRKoyjcAg" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0589752766" displayUnit="cm" />
-                    <Parameter id="_n3adhQ8-k2waVJEkWnWkw" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.024936327" displayUnit="cm" />
-                    <Parameter id="t0cJnRuWS0i_OcfE5p_Hxg" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.008680069" />
-                    <Parameter id="SEZK39f3G06iTf0m3G14wQ" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0019411088" displayUnit="cm" />
-                    <DistributedParameter id="eWo5o6BitEqIoehlT-JWDg" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="oJsfF0ZMAkO6HKeQKsL43w" mode="Logical" visible="1">
-                      <Children>
-                        <Parameter id="z_7B-JhTSUWugby-AA-X3Q" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                        <Parameter id="g77T-QYntUeC3S3HEJyDwg" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="447.9877" />
-                      </Children>
-                    </DistributedParameter>
-                    <MoleculeAmount id="V3v2rXqlRkujCVZ10rY3Ew" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                      <Children>
-                        <Parameter id="XzhtOsLP_k6dlIM0XaguyQ" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                        <Parameter id="PMbv-rzKpESNMEZvtzESNA" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IsTy33WB7ESR5_r-VDq4fA" visible="0" canBeVaried="0" />
-                        <Parameter id="3QR2TKaRRkqKC33ShQY1HA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="0" value="1" />
-                        <Parameter id="WMHAMZ6RaEar3qIlhSoNdA" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" visible="0" canBeVaried="0" rHSFormula="NDyMOymwm0yQw66TMuGSzQ" value="0" displayUnit="µmol" />
-                        <Parameter id="reDRrAsWe0Gft0qXkhCU7g" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DGEyVJxGRkK1vFKyY5Tb9w" visible="0" canBeVaried="0" />
-                        <Parameter id="9MSnMPzfK0C9zT8JYc4PVQ" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="xrez3w0g7UG-7-jsKxCtig" visible="0" canBeVaried="0" />
-                        <Parameter id="6e1EiU6JY0WpdSJ4pQyXeg" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="egztF40wwUyqvhK0oLwQZg" visible="0" canBeVaried="0" />
-                        <Parameter id="O0c9EHP8-0qrS7N4d8mrzw" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="3znCqMJedEeWcAqkoCQ7KA" visible="0" canBeVaried="0" />
-                        <Parameter id="rDNqgghbkEGBokaaF07lHQ" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="60q4D_3sgEOZGHAq37qGPw" visible="0" canBeVaried="0" />
-                        <Parameter id="ubkda2dEeUSOzyNiGfZtgA" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="plRy4piBG0OEqMb8trbv9g" visible="0" canBeVaried="0" />
-                        <Parameter id="wbV2YZywgEyV105Pc3lpcA" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IwQRVVSHzEWQSoTgefz5sQ" visible="0" canBeVaried="0" />
-                        <Parameter id="0csVeX7Tt0e2JGpVcCY-fQ" name="Solubility" description="Solubility" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" formula="tsOOTnC2UU2zmISrBvAOFQ" visible="1" canBeVaried="1" displayUnit="mg/l" />
-                        <Parameter id="zTXlIi0vXUKE4eGtTQ8-xg" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="J7Qsvqqb1keTr_tdW5wegw" visible="0" canBeVaried="0" />
-                        <Parameter id="D4KvVUTZykysUW1H7BrKWw" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="iloq2e2E40ePf5b_qWcdrg" visible="0" canBeVaried="0" />
-                        <Parameter id="qY6e1P053EiLuJ6w6ZqEdQ" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="gs9y_Kr0aE-bk5yS02Kq_g" visible="0" canBeVaried="0" />
-                        <Parameter id="RkE3u2ZTYUmG4KBPD0yiAQ" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="nyHnmg867k6GLa5z6gLmUg" visible="0" canBeVaried="0" />
-                        <Observer id="vY-A-iYK70yqE_OpChh_zw" name="Concentration in lumen" description="Concentration of the molecule in lumen" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="HLIRXIitt0KZivKUJbxfRQ" displayUnit="µmol/l" />
-                        <Observer id="AX0j6JOR6k2o7wUDuUSwnQ" name="Fraction of oral drug mass absorbed into mucosa segment" description="Fraction of oral drug mass absorbed into mucosa segment" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Drug, Observer" formula="XKRnaHqlW0S6GDKupu_dRA" />
-                      </Children>
-                    </MoleculeAmount>
-                  </Children>
-                </Container>
-                <Container id="MLkuT5b_ikmcYGRo2SAH3w" name="LowerJejunum" description="Lower Jejunum" icon="LowerJejunum" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Lumen" />
-                    <Tag value="LumenSegment" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="Rh4-o_scxki6bg6wPoyNXA" name="Volume (gut wall)" description="Volume of the gut wall" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="5y-0vqa4JEemn4qhaahvtg" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Parameter id="0K_fLjSrwkSJqNJg5xr4XQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="3tEyn06QHUaVxdoQ5QlHbA" name="Thickness of gut wall" description="Thickness of Gut Wall" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="PqZQXUcR2EuAADd5-fG5VQ" visible="0" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="hwwvAYYxC0agxuQfyHCRvw" name="Absorption of liquid" description="rate of liquid outflow" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="JgTYtaJfgEeLQD1AOzsihw" visible="0" canBeVaried="1" displayUnit="1/min" />
-                    <Parameter id="IsYPLbObaE-oShAZg4UK7g" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="cXeVNOGhxUGjgGD8PwjALA" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Parameter id="HnJdO705Lku9uhsnqiHiyQ" name="Distal radius" description="Distal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="F2HrUeP5gUqsHUmUBhdDeQ" visible="1" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="uPTGnsQfFEqvjz7awJpZPA" name="FillLevelFlag" description="Fill Level Flag" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="_fdpBznEC02u7-tLvw5OGQ" visible="0" canBeVaried="1" />
-                    <Parameter id="RGn1gJe9gkeW82Mo_9EX9w" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="OyHn7MCeuk6vmTKdv-iJqA" visible="0" canBeVaried="1" />
-                    <Parameter id="nCQV-vgw1EKUg-7oEwsImA" name="Geometric surface area" description="Geometric surface area of GI segment" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="9EhmHSAXZ0OXYPaSstfWrQ" visible="1" canBeVaried="1" displayUnit="cm²" />
-                    <Parameter id="8FTPaCYjakCXVcCXw6PZVA" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="Tc9frTEJLEyjWc-GvMys4g" visible="0" canBeVaried="1" displayUnit="1/min" />
-                    <Parameter id="Ufwt6IW1S0Csl5emoaMh7g" name="Length" description="Length" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="oHVl-7jv2UWh9dAin2b_Tg" visible="1" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="-xp8M8cneU68478bap8lfg" name="Liquid" description="Liquid" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="2aVY-_-FqE6bH8tHqQryGA" visible="0" canBeVaried="1" rHSFormula="3jroF04BMEOlyDLq4bRBAw" displayUnit="l" />
-                    <Parameter id="BkfZkVJiAEC8I4CkUPsJOQ" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="OkfQePrBfECGA3hs1qqX1A" visible="0" canBeVaried="0" displayUnit="l/min" />
-                    <Parameter id="JoBjsGxUAESOId11nVgIFw" name="Proximal radius" description="Proximal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="qXWNXa9UNUq30PzJeA1etg" visible="1" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="ukD7OmUT2EudtNOzJFkPBQ" name="Secretion of liquid" description="Rate of liquid inflow" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="1vNrydfJ5Em-7phSE4PkuA" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="km-HRFESjECaI1BIcJgyMQ" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0019411088" displayUnit="cm" />
-                    <Parameter id="c4LQhw4oWEep_J5CgPCVCA" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.30703115" displayUnit="1/cm" />
-                    <Parameter id="0keC_4LN-EKAuAMoiQHuzQ" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0465856499" displayUnit="cm" />
-                    <Parameter id="cjD6y-wiU0CH5PrEW2Vk2g" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.008101398" />
-                    <Parameter id="4tgCSloTtkW6PonYEGIAcw" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0018117016" displayUnit="cm" />
-                    <Parameter id="j-vTOgiH002W4jK-P1g3PQ" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.008680069" />
-                    <Parameter id="Gd7g8Hgzbki_kEowd0QkWw" name="Microvilli factor" description="Microvilli factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="25" />
-                    <Parameter id="XDlXiAyqLkSSQRDWTXUyoQ" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.299751712" />
-                    <Parameter id="Zn6etmCVw0CFVB_yAbMJvA" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0670329582" displayUnit="cm" />
-                    <Parameter id="enoqzbClLkaob1w6Wl0DSQ" name="Intestinal transit rate" description="Transit rate along intestinal segments" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" visible="0" canBeVaried="1" value="5.0162" displayUnit="1/min" />
-                    <Parameter id="oyp8hHf_0k6h2wSoqyY7dQ" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" visible="1" canBeVaried="1" value="0.064841" />
-                    <Parameter id="aHL_svOpoUSHpB58LTTsOQ" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0196976609" displayUnit="cm" />
-                    <Parameter id="Nfy_U5sDzUSUFhpePv7MHw" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="6.9167" />
-                    <DistributedParameter id="IYLd1oXNbUaW_GXTW5XCFw" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="2Kt5caoHS0KdWbYKUfpdtg" mode="Logical" visible="1">
-                      <Children>
-                        <Parameter id="8-lj-7XBH0WzaL12T7Df6Q" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                        <Parameter id="1IrGHJVf5UiVQq7DRVIi9w" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="372.9358" />
-                      </Children>
-                    </DistributedParameter>
-                    <MoleculeAmount id="Cuam5DbmZ0uqXwc9apFicg" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                      <Children>
-                        <Parameter id="EB64GfTPNkmOODmff2h4Gw" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                        <Parameter id="KQdUMC9ryEC7mBy-KarAFw" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="aN4I8buWo0eEk3yngEwT1w" visible="0" canBeVaried="0" />
-                        <Parameter id="8WTiL1Jj5UuAY31GkWsEqg" name="Solubility" description="Solubility" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" formula="Xt2eLR0Fa02jdW78uLhbeA" visible="1" canBeVaried="1" displayUnit="mg/l" />
-                        <Parameter id="A-O_scOQ-kGx0Gsf8S-OFg" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="iW9FGMf5rUu1J2AusqLApw" visible="0" canBeVaried="0" />
-                        <Parameter id="JQPum47tzUSuDii9kswesA" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="sFS16zII8UK80_G7p1CNMw" visible="0" canBeVaried="0" />
-                        <Parameter id="hPM6EEAux06JMGWQ-g4cAw" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" visible="0" canBeVaried="0" rHSFormula="93Q7I5MNFUq-uvM82-0r7A" value="0" displayUnit="µmol" />
-                        <Parameter id="nzdV5sS6-UyJ3vDr3suAug" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="-NfWkhhIYUWlzx1o9KPaVA" visible="0" canBeVaried="0" />
-                        <Parameter id="6vVJ1bzPukOaVm3_c8rFPw" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="YWy1DTlQVEGVQOcF-QNnlw" visible="0" canBeVaried="0" />
-                        <Parameter id="Gayjg4SzRUmES1ov_iD62Q" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="0" value="1" />
-                        <Parameter id="sqL6geOYZEyaP5dMmgw2TA" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="4pUB8pmQgUWSS3Zu4w1XWg" visible="0" canBeVaried="0" />
-                        <Parameter id="gbQDVDdImEWv3cE45ZwIXg" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Lo5toJ2Mb065Qge7yKCOTg" visible="0" canBeVaried="0" />
-                        <Parameter id="URJVlIkKOU6hTibxSTPTng" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="zp8h2QnihUeWKVIZolKKeQ" visible="0" canBeVaried="0" />
-                        <Parameter id="WEBxnbLBakqj34P1CvtMXA" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="qjHjURg7RE6cCRbY7lHGag" visible="0" canBeVaried="0" />
-                        <Parameter id="pNtss7ruZ0OTMU67TcSY5A" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="SiI4XqqmmkaX7lcZ8xHEXQ" visible="0" canBeVaried="0" />
-                        <Parameter id="qa9HDT0jRkSoeXUky3fRFw" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="p8AguT_fqkiiquvWRLPnDQ" visible="0" canBeVaried="0" />
-                        <Parameter id="r1lzC5wavU-x4hbEN9qtKw" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="bwD7i3vWBkqOb2zpTiYd5g" visible="0" canBeVaried="0" />
-                        <Observer id="go_OIBe0uUeuRgXJXfvs1w" name="Concentration in lumen" description="Concentration of the molecule in lumen" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="HLIRXIitt0KZivKUJbxfRQ" displayUnit="µmol/l" />
-                        <Observer id="whh6NYVIa0ihOsujk4D5mw" name="Fraction of oral drug mass absorbed into mucosa segment" description="Fraction of oral drug mass absorbed into mucosa segment" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Drug, Observer" formula="XKRnaHqlW0S6GDKupu_dRA" />
-                      </Children>
-                    </MoleculeAmount>
-                  </Children>
-                </Container>
-                <Container id="Ybii6aaw1UeIsuUX1COdYA" name="UpperIleum" description="Upper Ileum" icon="UpperIleum" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Lumen" />
-                    <Tag value="LumenSegment" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="wBj13kswJ02DJ3y53lSdIg" name="Secretion of liquid" description="Rate of liquid inflow" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="8o2JffWnMEam08XCYp6jtA" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="eZGkbfGar0mp2WFZ2RPsmA" name="Absorption of liquid" description="rate of liquid outflow" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="qymnPCBqoUiatZ4K3RdVzQ" visible="0" canBeVaried="1" displayUnit="1/min" />
-                    <Parameter id="78dFpGN9_0KzqV8iQebcPQ" name="Distal radius" description="Distal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="F2HrUeP5gUqsHUmUBhdDeQ" visible="1" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="rzdUVHAe6k-g4cvWzZS1dA" name="FillLevelFlag" description="Fill Level Flag" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="_fdpBznEC02u7-tLvw5OGQ" visible="0" canBeVaried="1" />
-                    <Parameter id="wsI46siIYEWtypjT25EwrA" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="OyHn7MCeuk6vmTKdv-iJqA" visible="0" canBeVaried="1" />
-                    <Parameter id="M-d1_m-mtUqGKzn1fHZNPg" name="Geometric surface area" description="Geometric surface area of GI segment" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="9EhmHSAXZ0OXYPaSstfWrQ" visible="1" canBeVaried="1" displayUnit="cm²" />
-                    <Parameter id="mbqJClRUeE6HWfriLgrxrg" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="cK8DjFkxEEGNUGx8llaOEA" visible="0" canBeVaried="1" displayUnit="1/min" />
-                    <Parameter id="oUHsaWuhHUqourM8arVUHQ" name="Length" description="Length" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="oHVl-7jv2UWh9dAin2b_Tg" visible="1" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="CRUdRj6n6kCZZnkvQnlYXg" name="Liquid" description="Liquid" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="2aVY-_-FqE6bH8tHqQryGA" visible="0" canBeVaried="1" rHSFormula="Wn5N2ABJf0ugRFlwrMSCrg" displayUnit="l" />
-                    <Parameter id="-5v_Pb2n-kinRWptolkKMQ" name="Proximal radius" description="Proximal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="qXWNXa9UNUq30PzJeA1etg" visible="1" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="5Ei6ZtEGCECRuCu0QCgHPQ" name="Thickness of gut wall" description="Thickness of Gut Wall" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="PqZQXUcR2EuAADd5-fG5VQ" visible="0" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="gybLE8_mCUGtNvtTK93XDQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="cXeVNOGhxUGjgGD8PwjALA" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Parameter id="gnsuB_wO00aeEY7f7qRdjQ" name="Volume (gut wall)" description="Volume of the gut wall" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="G7NxAykhCkSmNAYqluQxHQ" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Parameter id="TGCafDxTGEGxV9qJdcnFPA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="eMAMqgAaTEi_g4yldM83oA" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="pW3iUdfCO0-C_1badwoTyA" visible="0" canBeVaried="0" displayUnit="l/min" />
-                    <Parameter id="lCyREYTWj02vE6E62sXz1w" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.30703115" displayUnit="1/cm" />
-                    <Parameter id="p96fDagob0aSthvRhUrI2g" name="Intestinal transit rate" description="Transit rate along intestinal segments" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" visible="0" canBeVaried="1" value="3.3745" displayUnit="1/min" />
-                    <Parameter id="CeK12q1beEe2WR2ruDjdvA" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.061552122" displayUnit="cm" />
-                    <Parameter id="y5FBicCyZUC5Fyg4h3QW3w" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0260258863" displayUnit="cm" />
-                    <Parameter id="1jbmC8bpA0KgrB49dIEGTg" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.006944055" />
-                    <Parameter id="0lorbhBr7EeQAkRG8PYZqQ" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0015528871" displayUnit="cm" />
-                    <Parameter id="uQs94P9FsEegAIJrF0ulsw" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.008101398" />
-                    <Parameter id="3DV47zUn70KBFbroKchL-g" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0018117016" displayUnit="cm" />
-                    <Parameter id="Yvmbnm5LK0Kn3Bq-OgWLHw" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" visible="1" canBeVaried="1" value="0.064841" />
-                    <Parameter id="pQLMqh79cUm5WHVbkcE1-Q" name="Microvilli factor" description="Microvilli factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="25" />
-                    <Parameter id="KuHX_sS6_UmHu-zwZg7uzA" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.445576869" />
-                    <Parameter id="EtndjdcpN0-Lr_lyF4EXKA" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0996435866" displayUnit="cm" />
-                    <Parameter id="XCym0yfXpEu5w1Lkw5yqZw" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.2083" />
-                    <DistributedParameter id="YohPSPqvwkWc56ngHshpXg" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="QH4UVsJwgUK07576h4AXig" mode="Logical" visible="1">
-                      <Children>
-                        <Parameter id="6vBXTr6BJUmpwYTvoMvaXw" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                        <Parameter id="glJ2gGQatUy6zaUKrAS2vA" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="260.7527" />
-                      </Children>
-                    </DistributedParameter>
-                    <MoleculeAmount id="xrlOSQNSBk-WGtZ7E-tEYw" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                      <Children>
-                        <Parameter id="iqt33HrrUEauhSjXF32DDw" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                        <Parameter id="uvUyWM7tgkSMHqZ0KBhNKA" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="bEVArdud1UGoZClrP3zo4g" visible="0" canBeVaried="0" />
-                        <Parameter id="5I8jbeiYSEuo2tz6gn9uww" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="JTP53IXrY0izGazaDqvvOQ" visible="0" canBeVaried="0" />
-                        <Parameter id="4HTkyl4DeUG0rTILjiOJ6Q" name="Solubility" description="Solubility" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" formula="FE9I-0kS8U2LA87Fb9APRg" visible="1" canBeVaried="1" displayUnit="mg/l" />
-                        <Parameter id="VGhzw__pWUC8Tq6PMRkqeQ" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="5LpWfdD_3kyOVaUIMQF8VA" visible="0" canBeVaried="0" />
-                        <Parameter id="DlvYyiSY50Gv918UsWXcyw" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="BaoRoUEU2UinYhBcx3m7jw" visible="0" canBeVaried="0" />
-                        <Parameter id="4qSh4a2Y9EWqSNZucJW3hg" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="x-bIoOLEN0uxHaok7r6tOQ" visible="0" canBeVaried="0" />
-                        <Parameter id="TgOljyGjTUuo0sv0SkdcFQ" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="22IcA-bwP0WqKlOmyW-zDA" visible="0" canBeVaried="0" />
-                        <Parameter id="Cs86QNz8mkaWFmPefYnBYQ" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="AYz2QZjvZ0i2aQHJjl2AAw" visible="0" canBeVaried="0" />
-                        <Parameter id="OAXhgGX3UUSJnW3wQkDiHw" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="y-o_V2ISm06ZaFGZ5AXfbA" visible="0" canBeVaried="0" />
-                        <Parameter id="OhxW82r4I06RnBZd39ItoQ" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="knY6neYWUEek-ea_6E3jwA" visible="0" canBeVaried="0" />
-                        <Parameter id="uIsAuWn-DU6Z8LDr9RmSjg" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Onw5UqcBPE-qGQUvnTOKmQ" visible="0" canBeVaried="0" />
-                        <Parameter id="a5PIF7a8c0qk5kF2fRCoRg" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="FE2wBp5sF0KmWnbZUSwTBQ" visible="0" canBeVaried="0" />
-                        <Parameter id="dGWJZXI0TEWXYRnfl7Zgdw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="0" value="1" />
-                        <Parameter id="IzdqD0pqWECNLdX6TjpT8g" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" visible="0" canBeVaried="0" rHSFormula="FVx3U8qJfUu4rlWDPFgYug" value="0" displayUnit="µmol" />
-                        <Parameter id="p1r_2ixB8kW5TSxG7TrJmg" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="_-S90FYJ6ESeogTlHl7R6Q" visible="0" canBeVaried="0" />
-                        <Observer id="Kl-SE_gEOE2j8MQkG_HhTg" name="Concentration in lumen" description="Concentration of the molecule in lumen" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="HLIRXIitt0KZivKUJbxfRQ" displayUnit="µmol/l" />
-                        <Observer id="-zhMNQcRFUyeOttrcF--xA" name="Fraction of oral drug mass absorbed into mucosa segment" description="Fraction of oral drug mass absorbed into mucosa segment" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Drug, Observer" formula="XKRnaHqlW0S6GDKupu_dRA" />
-                      </Children>
-                    </MoleculeAmount>
-                  </Children>
-                </Container>
-                <Container id="igIrhkz7s0ehw7sHmKiBCg" name="LowerIleum" description="Lower Ileum" icon="LowerIleum" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Lumen" />
-                    <Tag value="LumenSegment" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="iEZLc8GZCUydSaX7qbCHtw" name="Geometric surface area" description="Geometric surface area of GI segment" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="9EhmHSAXZ0OXYPaSstfWrQ" visible="1" canBeVaried="1" displayUnit="cm²" />
-                    <Parameter id="Vf6MYykNzkyjFx6Pxe2cpg" name="Absorption of liquid" description="rate of liquid outflow" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="s_0soFODbUKpetWjYSVLkg" visible="0" canBeVaried="1" displayUnit="1/min" />
-                    <Parameter id="x7aiVgNZhk6X8al_MMFWjg" name="Distal radius" description="Distal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="F2HrUeP5gUqsHUmUBhdDeQ" visible="1" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="BubBnagzOkOAwT4CV4_Avw" name="FillLevelFlag" description="Fill Level Flag" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="_fdpBznEC02u7-tLvw5OGQ" visible="0" canBeVaried="1" />
-                    <Parameter id="dL9ufXOacUa41HSeaz_Ttw" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="Aj_NKEe8dkaRrZZFhRG4AA" visible="0" canBeVaried="1" displayUnit="1/min" />
-                    <Parameter id="jJapZ__rxUKjIMc0Lm-j1w" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="OyHn7MCeuk6vmTKdv-iJqA" visible="0" canBeVaried="1" />
-                    <Parameter id="cDBWZxwH3UCVAw26SFPaJg" name="Length" description="Length" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="oHVl-7jv2UWh9dAin2b_Tg" visible="1" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="ip2AAJNEG06lzhz9rnMCxA" name="Liquid" description="Liquid" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="2aVY-_-FqE6bH8tHqQryGA" visible="0" canBeVaried="1" rHSFormula="LupifbBVBEmekdHepYm0uQ" displayUnit="l" />
-                    <Parameter id="Q9517o0zTky4NFoxS3K8Lw" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="JP4_CmiR_kSxPAny5r2wxQ" visible="0" canBeVaried="0" displayUnit="l/min" />
-                    <Parameter id="P68w6wKAR0KMzjI_ZqTqzQ" name="Proximal radius" description="Proximal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="qXWNXa9UNUq30PzJeA1etg" visible="1" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="qf5NkZNzFEOC-OL8vbtrpA" name="Secretion of liquid" description="Rate of liquid inflow" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="thQOio6F7kewxcu6s2S89Q" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="Ftv9jS_ewU6jR67L-IFEvw" name="Thickness of gut wall" description="Thickness of Gut Wall" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="PqZQXUcR2EuAADd5-fG5VQ" visible="0" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="002YGAfWcEyVx4FkS83y6w" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="cXeVNOGhxUGjgGD8PwjALA" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Parameter id="L1EUSZllLE-YvOi9wFRzqg" name="Volume (gut wall)" description="Volume of the gut wall" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="isgoO6erJ0G64fE4n2H0uw" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Parameter id="kdqXg0ODvkSG0fZRFNxgmg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="8q9Z0DFxyUOVRGM7VfXW5Q" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" visible="1" canBeVaried="1" value="0.064841" />
-                    <Parameter id="ijK3iAVlLEmJj9M-mR-YCg" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0015528871" displayUnit="cm" />
-                    <Parameter id="U4bZ83f0JEar-myld429jw" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.30705627" displayUnit="1/cm" />
-                    <Parameter id="cobkBNBWpkGjkvrHX6EtrQ" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0350288649" displayUnit="cm" />
-                    <Parameter id="K1uhaN7Hika5_4ruH8jj6A" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0148137399" displayUnit="cm" />
-                    <Parameter id="QolCOrF9cEOEmWzUABB4Wg" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.005786713" />
-                    <Parameter id="vTSqnIsO8Ey7PNV279IY8w" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0012940725" displayUnit="cm" />
-                    <Parameter id="MJ-V8YuMN0GythPuB45cPQ" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.006944055" />
-                    <Parameter id="IdZwVNB0Hk6q0q481XykKQ" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.4583" />
-                    <Parameter id="TvWzlTetiUe6bty6Oob96g" name="Microvilli factor" description="Microvilli factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="25" />
-                    <Parameter id="uHceWaSnF0Gdr4cKBTnL0A" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.445576869" />
-                    <Parameter id="EYKeRhy4cUCSYU0ryH8QXw" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0996435866" displayUnit="cm" />
-                    <Parameter id="kh1iGCziFUyxlIPzZ7WebQ" name="Intestinal transit rate" description="Transit rate along intestinal segments" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" visible="0" canBeVaried="1" value="3.3745" displayUnit="1/min" />
-                    <DistributedParameter id="dxXYj4EJz0C9Ptoy0ZIDpw" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Vp8V_Q5xtU2pqdB7Yitbzw" mode="Logical" visible="1">
-                      <Children>
-                        <Parameter id="tjEQ1fWm4k2VHjbY5CZfIQ" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                        <Parameter id="7DMqe2AIoEmPd-zBz9bckA" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="146.565" />
-                      </Children>
-                    </DistributedParameter>
-                    <MoleculeAmount id="yw7rzbgJB0-l91_K8hz0sQ" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                      <Children>
-                        <Parameter id="NCGc1sgqB0WEepZMnmfj2w" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                        <Parameter id="hsl1q3FJRESyFifKCNZ_Hg" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="aIQxfz9QUEyGsLuHEO5Bgg" visible="0" canBeVaried="0" />
-                        <Parameter id="0_V0IhOVBE-82_jRMAtFvg" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" visible="0" canBeVaried="0" rHSFormula="MXQvgCsf9EiDrJgGVB91CQ" value="0" displayUnit="µmol" />
-                        <Parameter id="mHhJOdVLIEKbcwWH_MjDbw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="0" value="1" />
-                        <Parameter id="IT0cP1pYEUSzvLfMUiAVFw" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="OKpCXeOwvECRC2uDAGa-Yw" visible="0" canBeVaried="0" />
-                        <Parameter id="5GfsHYzYEEu_RzfQgspfKQ" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="7LL5Sb4f9Eqx7f99vqQKag" visible="0" canBeVaried="0" />
-                        <Parameter id="zlLQos0b-EigJOk_GaJV_A" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="zdAD-bmpPk-Mn9f-7CUt2g" visible="0" canBeVaried="0" />
-                        <Parameter id="UUvr8lhmvEmoBkI_hjZBwA" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="9_-jU0R0wUm4FFRuuvoDrw" visible="0" canBeVaried="0" />
-                        <Parameter id="9kpzAxTDCkWRmdbr64mABw" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="gPL6P9lkC0WRunhtCanL5w" visible="0" canBeVaried="0" />
-                        <Parameter id="WFDFS4u3aEKF88x5McGkTg" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="ntLRgZ_YBEypjXOnyfSFsA" visible="0" canBeVaried="0" />
-                        <Parameter id="sWsIzf1oX0KRvARoojzdWw" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="2qR4-Q_dF0qG7bDvwITD9A" visible="0" canBeVaried="0" />
-                        <Parameter id="TGokp3uqv0qPMZ9l4ex9nw" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="2TwYTvs_3Uym8juLZkUwcA" visible="0" canBeVaried="0" />
-                        <Parameter id="gnzzNyETkE-44GQM7cyAng" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="htoNv4JQiUCg6cLx_IGNZQ" visible="0" canBeVaried="0" />
-                        <Parameter id="aymuK0FZTUyOn1cO983e6g" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="9qw9_EzVekiYMI1JMxSBVw" visible="0" canBeVaried="0" />
-                        <Parameter id="7JRyX4kJHkOyPK2PvhCCDQ" name="Solubility" description="Solubility" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" formula="2XepGwIJ10CHcpnFwYN2HA" visible="1" canBeVaried="1" displayUnit="mg/l" />
-                        <Parameter id="l153DMdGtEaqnupiogGLqQ" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="MHsXYLFYY0yZVJCwqVw22g" visible="0" canBeVaried="0" />
-                        <Observer id="Gd1v8-mYnEOaX5TGGQ8Ztw" name="Concentration in lumen" description="Concentration of the molecule in lumen" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="HLIRXIitt0KZivKUJbxfRQ" displayUnit="µmol/l" />
-                        <Observer id="kYwFCQ6VzkaiQ_IufhsOmg" name="Fraction of oral drug mass absorbed into mucosa segment" description="Fraction of oral drug mass absorbed into mucosa segment" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Drug, Observer" formula="XKRnaHqlW0S6GDKupu_dRA" />
-                      </Children>
-                    </MoleculeAmount>
-                  </Children>
-                </Container>
-                <Container id="jlQkJ9VHjEatlpKzMFmnlw" name="Caecum" description="Cecum" icon="Caecum" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Lumen" />
-                    <Tag value="LumenSegment" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="ETtNy8fPXUu3H76A6Zwniw" name="Volume (gut wall)" description="Volume of the gut wall" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="PFC67js_70youvGPUOKj7g" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Parameter id="IKYh-NES4ECM3dl1m81orA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="fGJXJxYEb0G-wRofBkXWuQ" name="Distal radius" description="Distal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="F2HrUeP5gUqsHUmUBhdDeQ" visible="1" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="y5j4hD93U0GraxWprT9Gcg" name="Absorption of liquid" description="rate of liquid outflow" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="f9HBe0HL8UmV2kHSSUfujQ" visible="0" canBeVaried="1" displayUnit="1/min" />
-                    <Parameter id="Sbz_kzny5UOeerYdOhjiew" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="cXeVNOGhxUGjgGD8PwjALA" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Parameter id="pKukkTOflUWhvHNziVO59w" name="FillLevelFlag" description="Fill Level Flag" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="_fdpBznEC02u7-tLvw5OGQ" visible="0" canBeVaried="1" />
-                    <Parameter id="ZHhp4Pw270qkLneE4j4VRA" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="OyHn7MCeuk6vmTKdv-iJqA" visible="0" canBeVaried="1" />
-                    <Parameter id="UOvzTeStFkuWN9EAR6hpdA" name="Geometric surface area" description="Geometric surface area of GI segment" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="9EhmHSAXZ0OXYPaSstfWrQ" visible="1" canBeVaried="1" displayUnit="cm²" />
-                    <Parameter id="K_p5OF_WyEiYltk4_9axCg" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="z9OQBOCK6E2zipk0n2QTMQ" visible="0" canBeVaried="1" displayUnit="1/min" />
-                    <Parameter id="xTmqrMdYvkucrRLSX2tKDQ" name="Length" description="Length" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="oHVl-7jv2UWh9dAin2b_Tg" visible="1" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="-yKg0C0uAUe-1KAy0cvybA" name="Liquid" description="Liquid" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="2aVY-_-FqE6bH8tHqQryGA" visible="0" canBeVaried="1" rHSFormula="pOiAX9pLB0uZgXER87e-WQ" displayUnit="l" />
-                    <Parameter id="X2Anb_VXkUqWkvAwisY8VQ" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="f3gnAjMwYkSqpHnWwnByAg" visible="0" canBeVaried="0" displayUnit="l/min" />
-                    <Parameter id="LCkxywRk1UmJjYjdz-2iDQ" name="Proximal radius" description="Proximal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="qXWNXa9UNUq30PzJeA1etg" visible="1" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="9Q2JYu4WBkK1f5fQS1gl9g" name="Secretion of liquid" description="Rate of liquid inflow" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="5hQhqmmOGke7bHC6ZbrX1g" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="15-1DTPN-EGTHAqWwMC7zA" name="Thickness of gut wall" description="Thickness of Gut Wall" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="PqZQXUcR2EuAADd5-fG5VQ" visible="0" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="1-ASB6HmsEO9ljEJ8wUH1A" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0060009" />
-                    <Parameter id="QdGkfFdfKUC6ZfqWMG4whg" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0446435379" displayUnit="cm" />
-                    <Parameter id="vccmsdNeIkGiHyov9RKVQA" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.00877" displayUnit="cm" />
-                    <Parameter id="hLVoK4nX4kuGAavJfabp8Q" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.015672726" />
-                    <Parameter id="IwuRZk77lk2olnrXXZGZwg" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.067256381" displayUnit="cm" />
-                    <Parameter id="DOilEaH7skqb2-Jll5eC9w" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.015672726" />
-                    <Parameter id="lyudiZs4AkO2O6oH96DJrQ" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.067256381" displayUnit="cm" />
-                    <Parameter id="DrcZBzgCM0OPHkZ7vkp1Ag" name="Microvilli factor" description="Microvilli factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                    <Parameter id="IDV_YFbqC0a4KJhIo7I3og" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.026864843" />
-                    <Parameter id="LcWEggGcckaKwWj_Mw6aAg" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.1152851235" displayUnit="cm" />
-                    <Parameter id="32w5AIkIdUC5PIW6slsQ0g" name="Intestinal transit rate" description="Transit rate along intestinal segments" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" visible="0" canBeVaried="1" value="18.3333" displayUnit="1/min" />
-                    <Parameter id="neMEW6zLKUqoX0JAiqzUjw" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0897885" displayUnit="1/cm" />
-                    <Parameter id="tEx9Ec7RgUGQ5lYf9vd19g" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="5.7" />
-                    <DistributedParameter id="kSkgmIv-DEubNyE70rL5rw" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="-baRJqE1DUqWtbof0YF_YA" mode="Logical" visible="1">
-                      <Children>
-                        <Parameter id="0C5leecwsUGPcJq7jfcZLw" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                        <Parameter id="AlTDXBbaC0akMJkl-gMfkw" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1.8" />
-                      </Children>
-                    </DistributedParameter>
-                    <MoleculeAmount id="Qnj6YM6q_kSvSvGmWycE8g" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                      <Children>
-                        <Parameter id="z-tvs9pyPEunDjDD-CxpPA" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                        <Parameter id="bKTPNFNwYkm7tnIWA7DBQg" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Z_8QtWZYpkmF7tOvsFbRAA" visible="0" canBeVaried="0" />
-                        <Parameter id="Keo3NR-Mbkiz3TDRfUKAnA" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" visible="0" canBeVaried="0" rHSFormula="_il3MCSTWUiE2lh0y_BsLw" value="0" displayUnit="µmol" />
-                        <Parameter id="CULivekKT0OtuNVr53FyUA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="0" value="1" />
-                        <Parameter id="13ZINrsj7USBW0xRqcBKrQ" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="XN4Nstf-oE6ZK8B6ftJRoA" visible="0" canBeVaried="0" />
-                        <Parameter id="rjD1DjJft0SFhChbV-DdUQ" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="ubFUF91rwEqEt-dhtUno4w" visible="0" canBeVaried="0" />
-                        <Parameter id="ChFfiPhefEWS5jFuA1KF-Q" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="1bolpQyjCUqPJl6YMdn9HA" visible="0" canBeVaried="0" />
-                        <Parameter id="5jEeLC9_hUyLSKQ0SCWaSg" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IHwyL-TOZE2li9aQxl0Ctw" visible="0" canBeVaried="0" />
-                        <Parameter id="rIpQiDtFHEqiIbX6uKtDIw" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="k4Oz6d5fbEOtOd2Z_6DabQ" visible="0" canBeVaried="0" />
-                        <Parameter id="pzo6Kyfuxkufu2G_wzioWg" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="mpNA-y-MbU2hzf6lDcPC6Q" visible="0" canBeVaried="0" />
-                        <Parameter id="oTjyYYrP1UGSx0AopoKGRg" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="U-IxP7womkCOuKD2CjS1Cg" visible="0" canBeVaried="0" />
-                        <Parameter id="M9-vy5CyXEyJkqn9IsCIrA" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="uu0iNyOEXUW76JP4k3aZFg" visible="0" canBeVaried="0" />
-                        <Parameter id="ifzwRxe-f0-DPP9ejNey6w" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="H0sGnbLJZ0mGwSW95-xv4g" visible="0" canBeVaried="0" />
-                        <Parameter id="sAfqE4c7L0aGWghRkC9A0g" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="3siuSAxgbE6O2WDhSdM-xQ" visible="0" canBeVaried="0" />
-                        <Parameter id="YjDbiMlMuEG_YfbVvSHbjw" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="iHU7Psc53UORagpTRLU1zQ" visible="0" canBeVaried="0" />
-                        <Parameter id="Ikm0BtxRTUqley3CGokJXQ" name="Solubility" description="Solubility" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" formula="MJmhdMeuUk2lV8g4IxOHjQ" visible="1" canBeVaried="1" displayUnit="mg/l" />
-                        <Observer id="E-mf9FnuW0O8QM4DVLBH0w" name="Concentration in lumen" description="Concentration of the molecule in lumen" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="HLIRXIitt0KZivKUJbxfRQ" displayUnit="µmol/l" />
-                        <Observer id="lZAmpmIBgkm8n9lbIBDZtw" name="Fraction of oral drug mass absorbed into mucosa segment" description="Fraction of oral drug mass absorbed into mucosa segment" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Drug, Observer" formula="XKRnaHqlW0S6GDKupu_dRA" />
-                      </Children>
-                    </MoleculeAmount>
-                  </Children>
-                </Container>
-                <Container id="jhPiKsemqE2D9wuuFrqxsw" name="ColonAscendens" description="Colon Ascendens" icon="ColonAscendens" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Lumen" />
-                    <Tag value="LumenSegment" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="viUBPgP4FUK_3eZBMPCGxg" name="Thickness of gut wall" description="Thickness of Gut Wall" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="PqZQXUcR2EuAADd5-fG5VQ" visible="0" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="nXvIZfckWUqosYWDmm0cIg" name="Absorption of liquid" description="rate of liquid outflow" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="hsbpi7xT1E2clUp4OmI6ag" visible="0" canBeVaried="1" displayUnit="1/min" />
-                    <Parameter id="eGMttTl0V0W0RMJ2L8QViA" name="Distal radius" description="Distal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="F2HrUeP5gUqsHUmUBhdDeQ" visible="1" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="gNmWCuhP9kiQt9cPANSeXw" name="FillLevelFlag" description="Fill Level Flag" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="_fdpBznEC02u7-tLvw5OGQ" visible="0" canBeVaried="1" />
-                    <Parameter id="d2vIMcDAKESuZAHZxEohDQ" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="OyHn7MCeuk6vmTKdv-iJqA" visible="0" canBeVaried="1" />
-                    <Parameter id="3eZlQCE3FkeuXad6xURPSg" name="Geometric surface area" description="Geometric surface area of GI segment" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="9EhmHSAXZ0OXYPaSstfWrQ" visible="1" canBeVaried="1" displayUnit="cm²" />
-                    <Parameter id="NcHuuOAjc0i_fMF1eULoqQ" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="Keua_BuW1k2l_Gge2of7ww" visible="0" canBeVaried="1" displayUnit="1/min" />
-                    <Parameter id="pDdbH7wLa0OvSkn53cBYXQ" name="Length" description="Length" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="oHVl-7jv2UWh9dAin2b_Tg" visible="1" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="YsOTQRKkrESKlbeQkDpmug" name="Liquid" description="Liquid" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="2aVY-_-FqE6bH8tHqQryGA" visible="0" canBeVaried="1" rHSFormula="pE6rnbsnZUWygxN7Qr-xdA" displayUnit="l" />
-                    <Parameter id="niqqv9Bsj0ibrdabvHvGCg" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="V73iJSoFf0KmfHIyK8jajg" visible="0" canBeVaried="0" displayUnit="l/min" />
-                    <Parameter id="Jbwur_7UgUa5N-v5BDkZNg" name="Secretion of liquid" description="Rate of liquid inflow" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="sIvtfRuZGkiGAMEyVUNjKQ" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="AxsZYrYIVkG-bne9IzqyPg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="cXeVNOGhxUGjgGD8PwjALA" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Parameter id="XYbAu0-Wv0Kz7uG5CPPdIg" name="Volume (gut wall)" description="Volume of the gut wall" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="nCuzY3r2z0eZnR2YrlGvoA" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Parameter id="B-ttu-fJJUSCzoD6i52NGg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="DnUJgRHuPk-8Mncp4a6YGA" name="Proximal radius" description="Proximal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="qXWNXa9UNUq30PzJeA1etg" visible="1" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="VbSJtYtMbE2yT4GFgVjBZw" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.09106073" displayUnit="1/cm" />
-                    <Parameter id="-qYLs4bSjEGvqvawLnA-lg" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0280138174" displayUnit="cm" />
-                    <Parameter id="O565L-KzoEOStOzD_KuVeg" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.00554" displayUnit="cm" />
-                    <Parameter id="FztntaLATUW9uOVtvhb59g" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.067256381" displayUnit="cm" />
-                    <Parameter id="yO6xjHtmukmaQGuA5MSANw" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.015672726" />
-                    <Parameter id="P1pJLTZqpkOLm74ZbCPexg" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.067256381" displayUnit="cm" />
-                    <Parameter id="Wj-BofA-q0WGikbRsvqxnw" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="5.6" />
-                    <Parameter id="z7t-Q1ZK-0SsJY1nbOJwPA" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.015672726" />
-                    <Parameter id="pnjmMeLRbEq0_yrSQQdtNA" name="Microvilli factor" description="Microvilli factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                    <Parameter id="5_816Br5IkGM3HRcx04aew" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.075727844" />
-                    <Parameter id="Q5nhY0loSE-p_1gmjCcvUA" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.3117189273" displayUnit="cm" />
-                    <Parameter id="j4GqQSoM5EWOhLtkLSqtIQ" name="Intestinal transit rate" description="Transit rate along intestinal segments" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" visible="0" canBeVaried="1" value="10" displayUnit="1/min" />
-                    <Parameter id="HKa3-9zVI0ezT-QGqs_9Lw" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0060009" />
-                    <DistributedParameter id="b0k9TcYtYEWXk-d_XuAdPQ" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="AeGMbLE2cUS4irWuGT7unA" mode="Logical" visible="1">
-                      <Children>
-                        <Parameter id="Tj8wBvj9jEyAsIhmsX6HEw" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                        <Parameter id="U2h7w1CoGES0AaxcgBk8Iw" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="2.5" />
-                      </Children>
-                    </DistributedParameter>
-                    <MoleculeAmount id="mgzsCzTwXkGLoEv-ZBAnNQ" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                      <Children>
-                        <Parameter id="NYR44YSrpEu4vR_CKzdRWA" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                        <Parameter id="DkTgs_vot0aPvJK035ihrw" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="b1LiiQ0hskCyDFLoo43Ypw" visible="0" canBeVaried="0" />
-                        <Parameter id="T3AmJ1RlC0unhkO5L2IY9Q" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" visible="0" canBeVaried="0" rHSFormula="jgxVl4G6HUew1s0pFs2YLQ" value="0" displayUnit="µmol" />
-                        <Parameter id="68GtnWD0pE2x76A0X1gqZg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="0" value="1" />
-                        <Parameter id="-tZguRjEbkK74oZJjB2TrQ" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="SW_PRV0KqEqJbLZiAus_lg" visible="0" canBeVaried="0" />
-                        <Parameter id="R_CinLF8mk6luTb55Nag-Q" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="HWSY_xl2AUiWHWGE6V-3jg" visible="0" canBeVaried="0" />
-                        <Parameter id="pom1r-60LEaIIYk5F9fK7g" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Ggw3OrO94U-wZt0r_BUEJg" visible="0" canBeVaried="0" />
-                        <Parameter id="DcZxs4_HfEylmorMM_UYyg" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="8M3ZoeHu_kqyUJbcGPEFuA" visible="0" canBeVaried="0" />
-                        <Parameter id="_UYGnx3FlEqQhPMFKibAng" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="dRgr10eL1UOyec_t1ot7pg" visible="0" canBeVaried="0" />
-                        <Parameter id="tAslZNTfKEiYsBA9zVP2Qg" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="irJBnJOa1Eu1D6iMXnQOZA" visible="0" canBeVaried="0" />
-                        <Parameter id="o16oLB3iC0WxPt_lD7tIJw" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="5qwiI5giNUy5v6RxrdhxXw" visible="0" canBeVaried="0" />
-                        <Parameter id="W2ckH7org0yUYXehngAq5g" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="rwH9RrRW60aNss0oo6CE3Q" visible="0" canBeVaried="0" />
-                        <Parameter id="Vy2D36VEn0m1-_tLt7xtyg" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="HWqOrSLC9k6JpQrAiuBvjQ" visible="0" canBeVaried="0" />
-                        <Parameter id="M-x4DgJ9Hkqg5Dl_zqTdrw" name="Solubility" description="Solubility" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" formula="jRV0gel0lEWesI2wpShosA" visible="1" canBeVaried="1" displayUnit="mg/l" />
-                        <Parameter id="JroOce2YQkuIHKlJGpFVQQ" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="t3_sADOHakqfJmYssd61DQ" visible="0" canBeVaried="0" />
-                        <Parameter id="_VpPYsxkk0-GcpvnlNqazQ" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="iJ74yhoyJE2_i3u1M1Uvlw" visible="0" canBeVaried="0" />
-                        <Observer id="XnRtO9Uob06Kfn8ARYwGrg" name="Concentration in lumen" description="Concentration of the molecule in lumen" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="HLIRXIitt0KZivKUJbxfRQ" displayUnit="µmol/l" />
-                        <Observer id="WNeg8kWzZUa1FtfNcaH9LQ" name="Fraction of oral drug mass absorbed into mucosa segment" description="Fraction of oral drug mass absorbed into mucosa segment" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Drug, Observer" formula="XKRnaHqlW0S6GDKupu_dRA" />
-                      </Children>
-                    </MoleculeAmount>
-                  </Children>
-                </Container>
-                <Container id="uB1rpzG6qkapR36UK4VYNQ" name="ColonTransversum" description="Colon Transversum" icon="ColonTransversum" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Lumen" />
-                    <Tag value="LumenSegment" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="jNEEPVxkbU2ePlzqO2Jm8g" name="Length" description="Length" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="oHVl-7jv2UWh9dAin2b_Tg" visible="1" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="sAWg6SmKXk6pC6bp-2sv3g" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="7fdUDwplw0WiOkakEWoWEA" visible="0" canBeVaried="0" displayUnit="l/min" />
-                    <Parameter id="Dy3MqxJZFEKb7019_D_35Q" name="Proximal radius" description="Proximal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="qXWNXa9UNUq30PzJeA1etg" visible="1" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="Q2tNRHcaREuxREsL1iT-rQ" name="Secretion of liquid" description="Rate of liquid inflow" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="6js66GFelUmQLvMVM6oP8w" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="yFEyRL_wf0inEXGl04QyDA" name="Thickness of gut wall" description="Thickness of Gut Wall" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="PqZQXUcR2EuAADd5-fG5VQ" visible="0" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="uD4hppWaikKWu68AoixnxQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="cXeVNOGhxUGjgGD8PwjALA" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Parameter id="Dcxn0qaLvUmr8dlcgmwxyg" name="Volume (gut wall)" description="Volume of the gut wall" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="y8uL8Z02ZUWxdjoyEPj0Bw" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Parameter id="bum4w5VoCUOGCedPAwNA3Q" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="D6VkGMBZ3EW2acunMU40SA" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="QbA_GGKf80GS1JTZAMtNuA" visible="0" canBeVaried="1" displayUnit="1/min" />
-                    <Parameter id="wlzVcV3wkEKSzjZN4wA7cA" name="Liquid" description="Liquid" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="2aVY-_-FqE6bH8tHqQryGA" visible="0" canBeVaried="1" rHSFormula="0YkdyYjRGUmf7qUM1iVnMQ" displayUnit="l" />
-                    <Parameter id="fgLv5LsNvkO2ZBweWDu5vA" name="Absorption of liquid" description="rate of liquid outflow" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="DGdP-ITmVUeHI6_DPzp-0g" visible="0" canBeVaried="1" displayUnit="1/min" />
-                    <Parameter id="tnoG6c7fhE6x3MFpm-l3BQ" name="Distal radius" description="Distal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="F2HrUeP5gUqsHUmUBhdDeQ" visible="1" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="ZAI6Fu-k3UygZPM-GnxVKg" name="FillLevelFlag" description="Fill Level Flag" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="_fdpBznEC02u7-tLvw5OGQ" visible="0" canBeVaried="1" />
-                    <Parameter id="XiH5iNALrEewkmRWSbZWKA" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="OyHn7MCeuk6vmTKdv-iJqA" visible="0" canBeVaried="1" />
-                    <Parameter id="o33tiAP5REGc6rV0qkx4cw" name="Geometric surface area" description="Geometric surface area of GI segment" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="9EhmHSAXZ0OXYPaSstfWrQ" visible="1" canBeVaried="1" displayUnit="cm²" />
-                    <Parameter id="PKOazY8sukOxaADwkjUnBw" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0060009" />
-                    <Parameter id="y__S3_2JLkmrD3talagKMA" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.6886041141" displayUnit="cm" />
-                    <Parameter id="_40R8pV2-0etYJyB_dAZCA" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0384322177" displayUnit="cm" />
-                    <Parameter id="Q9Xf8WCpg0-BWzQCg6bQhg" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.08637087" displayUnit="1/cm" />
-                    <Parameter id="jFR6o8lDCEqAVAnvq7mvag" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0394956146" displayUnit="cm" />
-                    <Parameter id="DYmlhB-5KU-VKmhEUkiEfA" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0076" displayUnit="cm" />
-                    <Parameter id="xVOYjkvAp0S-Zuwj96OGsA" name="Intestinal transit rate" description="Transit rate along intestinal segments" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" visible="0" canBeVaried="1" value="3.3333" displayUnit="1/min" />
-                    <Parameter id="DboOrsPL-EOkBGgXQ27THQ" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.008955843" />
-                    <Parameter id="C4DJ4VGkpEmeIckYu3O-bw" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.015672726" />
-                    <Parameter id="rHfAC4fA30SV5pAIYWySEw" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.067256381" displayUnit="cm" />
-                    <Parameter id="mG5sjE0APkWnXgpU6UVLAQ" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="5.7" />
-                    <Parameter id="-Fb0Z4SBJ06eBRkkT4b54g" name="Microvilli factor" description="Microvilli factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                    <Parameter id="GVxqBl6rskWlogryGnV-Ow" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.144607745" />
-                    <DistributedParameter id="zXE3zkNXd0eSle_S8Frknw" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="WUCHh7x9b0eyXwH2Zj1VQg" mode="Logical" visible="1">
-                      <Children>
-                        <Parameter id="Zdpa7z_jhEyE-2qd5Qb1Xg" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                        <Parameter id="SUDP3-J_dkObk8FtvYIbEw" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="2.5" />
-                      </Children>
-                    </DistributedParameter>
-                    <MoleculeAmount id="B3i4ajvEPkWwF-QJhPT-RA" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                      <Children>
-                        <Parameter id="9c66-sM9NEejqMcRITIIJQ" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                        <Parameter id="Pi9i5cKxiE6-vKfD4W0-uA" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Q9kDdbKabUqCU8YRbICCFQ" visible="0" canBeVaried="0" />
-                        <Parameter id="OPUd0Ru8n0SOzjb8yfWL2w" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="q2ngvYO4F0aE35RZDOmYhA" visible="0" canBeVaried="0" />
-                        <Parameter id="Fuqpjr48aUyYo2KFaSFyOQ" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IwKGVBSlFE21Zy990gnjlQ" visible="0" canBeVaried="0" />
-                        <Parameter id="3hCsfym3S0GRHhiAWSBvMw" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Q9eqrJvCWEq8nOmcz-ASPg" visible="0" canBeVaried="0" />
-                        <Parameter id="M8UZXqxqWk6RRRSX5JD_Bg" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="V3iIHI8vJUeND9mEeb86IA" visible="0" canBeVaried="0" />
-                        <Parameter id="ptXXTZtN_kW7DDHdLQXCaA" name="Solubility" description="Solubility" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" formula="Lfbs-GRlGE6rThSBKfltmA" visible="1" canBeVaried="1" displayUnit="mg/l" />
-                        <Parameter id="DiNIDiaAmE2JQriAZmdG9A" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="S9NYSx9sCky5bOpOKmGBpA" visible="0" canBeVaried="0" />
-                        <Parameter id="n1y2IqEQ8kGpCCO2b0JLqw" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="KA242Rj6pUO9r6mghCA2Gw" visible="0" canBeVaried="0" />
-                        <Parameter id="wioYh6s10k6zSSYEImDpSg" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="XPQ_zkSV-E-P6CCOCOPKXQ" visible="0" canBeVaried="0" />
-                        <Parameter id="DKaFclPE-USexNiwawLGzg" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Oc8ZKRbYKUSas4YeW5s05Q" visible="0" canBeVaried="0" />
-                        <Parameter id="D02-fSSDQEaWHiuHBMnrhQ" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" visible="0" canBeVaried="0" rHSFormula="G8mRjslt9Uqc-waxWogQ8Q" value="0" displayUnit="µmol" />
-                        <Parameter id="4r3rO6rJ8UumIsHnhZmBTA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="0" value="1" />
-                        <Parameter id="KjNIeyvXtE-5xdH5Hih-Ug" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="4ZnAyRse80mPg9gopNYdMQ" visible="0" canBeVaried="0" />
-                        <Parameter id="ozaik5pDsEyc8ehRJnnWIw" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="yUOCf5_22EC69VdC3J-FVA" visible="0" canBeVaried="0" />
-                        <Parameter id="QO_Km-1tVUe6RaoJ5oU-kA" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="NOxJMq20mkS0ZLthD0EjMA" visible="0" canBeVaried="0" />
-                        <Observer id="hslvxNXcE0ef5wYbo9yoKg" name="Concentration in lumen" description="Concentration of the molecule in lumen" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="HLIRXIitt0KZivKUJbxfRQ" displayUnit="µmol/l" />
-                        <Observer id="Xq8JxZzhFUqDSA9xlRmEtw" name="Fraction of oral drug mass absorbed into mucosa segment" description="Fraction of oral drug mass absorbed into mucosa segment" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Drug, Observer" formula="XKRnaHqlW0S6GDKupu_dRA" />
-                      </Children>
-                    </MoleculeAmount>
-                  </Children>
-                </Container>
-                <Container id="Tizt5eh3cUGAxWKaiYKVQw" name="ColonDescendens" description="Colon Descendens / Distal Colon 1" icon="ColonDescendens" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Lumen" />
-                    <Tag value="LumenSegment" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="XYoe-kxC0kaI3muOqMG6tA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="eoVfC5mgMkizifUbhy-FjQ" name="FillLevelFlag" description="Fill Level Flag" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="_fdpBznEC02u7-tLvw5OGQ" visible="0" canBeVaried="1" />
-                    <Parameter id="_u9Qu1OuIUeLwDtxdJ832g" name="Volume (gut wall)" description="Volume of the gut wall" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="u5ojFsBtEkm-beiLO4vDoQ" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Parameter id="5yFrg5ufv0yefLnP-5V1Ng" name="Distal radius" description="Distal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="F2HrUeP5gUqsHUmUBhdDeQ" visible="1" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="i1ekRF8LO0C7obBPe44OdA" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="OyHn7MCeuk6vmTKdv-iJqA" visible="0" canBeVaried="1" />
-                    <Parameter id="Vd-vzBcUBkaz2ayhL8QWpg" name="Geometric surface area" description="Geometric surface area of GI segment" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="9EhmHSAXZ0OXYPaSstfWrQ" visible="1" canBeVaried="1" displayUnit="cm²" />
-                    <Parameter id="kZppsGdyyU-wO6LjXUceNw" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="PWQzN2eIlESR-tMyGqGAag" visible="0" canBeVaried="1" displayUnit="1/min" />
-                    <Parameter id="90dShX49bk6U71PBC5DNGQ" name="Length" description="Length" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="oHVl-7jv2UWh9dAin2b_Tg" visible="1" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="yLEWhm3bQEmjjGb4QwFAKA" name="Liquid" description="Liquid" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="2aVY-_-FqE6bH8tHqQryGA" visible="0" canBeVaried="1" rHSFormula="iueu9e24tU6khEDO0Vzp3g" displayUnit="l" />
-                    <Parameter id="MlqGkvwkG0SRMuV4N2cTTg" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="vu-Ba5lRpUSOjziCwL-4GQ" visible="0" canBeVaried="0" displayUnit="l/min" />
-                    <Parameter id="VA2hfWcf2EuumsV0CCQv4g" name="Proximal radius" description="Proximal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="qXWNXa9UNUq30PzJeA1etg" visible="1" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="KoE2onFqkkC2IuKURAKLSw" name="Secretion of liquid" description="Rate of liquid inflow" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="z5f4Mbfsj0u0sDsk5aYOkw" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="QwdkxYEifEib5359jWWVNQ" name="Thickness of gut wall" description="Thickness of Gut Wall" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="PqZQXUcR2EuAADd5-fG5VQ" visible="0" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="KSkAAnA4F0Gsdp7rZlCxyQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="cXeVNOGhxUGjgGD8PwjALA" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Parameter id="A8htP2cxkUSvIuMBXBx8Rg" name="Absorption of liquid" description="rate of liquid outflow" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="DJ5wJfvnZEOiN86L1zgO7w" visible="0" canBeVaried="1" displayUnit="1/min" />
-                    <Parameter id="m6PlogT2mUC_4yikuXDS_w" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0384322177" displayUnit="cm" />
-                    <Parameter id="EBlTTE1Tn0mUmAfjs3djug" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.008955843" />
-                    <Parameter id="440OlT3N-06cmw8f_CNYjQ" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0384322177" displayUnit="cm" />
-                    <Parameter id="VDGEkpclpk6mSS7CoMf1_A" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="6.6" />
-                    <Parameter id="ox3-7b20ekue6IYzFrirrQ" name="Microvilli factor" description="Microvilli factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                    <Parameter id="XgaSzOpRPUCrvGAo8UtNxQ" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.098514277" />
-                    <Parameter id="HVU2NIN99Ea9uXbE8SVtvg" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.4227543951" displayUnit="cm" />
-                    <Parameter id="4A9DPxWwmUiPpaXaj-G3Kg" name="Intestinal transit rate" description="Transit rate along intestinal segments" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" visible="0" canBeVaried="1" value="5" displayUnit="1/min" />
-                    <Parameter id="pzSvjbgjIEOwi9eFRQWXbg" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.008955843" />
-                    <Parameter id="7LdDP8PDMEeTFsXm1GC2Gg" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.08977747" displayUnit="1/cm" />
-                    <Parameter id="muI5H60zkEuZaDvgYPZmRw" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0601543776" displayUnit="cm" />
-                    <Parameter id="4aXOpZk4J0ewsz6l4mB_Ig" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0118" displayUnit="cm" />
-                    <Parameter id="W70_HD5JLE-z-h9ixFE5jQ" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0060009" />
-                    <DistributedParameter id="S93xmEnP20WSwHiWtzThXQ" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="4d_tSWwpMEWOUqfVXqOSSw" mode="Logical" visible="1">
-                      <Children>
-                        <Parameter id="nVHGtCbXLUOnVOU6g7BZZw" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                        <Parameter id="BEsp2Zlzok2KnRXIcXSx6w" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="2.5" />
-                      </Children>
-                    </DistributedParameter>
-                    <MoleculeAmount id="yiZ323gtz0WRt_37u8tDPQ" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                      <Children>
-                        <Parameter id="-RNo_u2RLUiPrateHg-bsQ" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                        <Parameter id="8SGLOlxhnEiIQgXq7suTQQ" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="5SmaX5z-v0On9zuR6oIO4w" visible="0" canBeVaried="0" />
-                        <Parameter id="huScLJAkm0--QG0yrFVFNg" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="sqZulsxJqUiHCvvlJ_eqFQ" visible="0" canBeVaried="0" />
-                        <Parameter id="2eICo8mlwEGa2TIoVTfi_Q" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="tAvMptOyqUWokQ-Ft9Ynrw" visible="0" canBeVaried="0" />
-                        <Parameter id="T1EaA5qTy0i2KNa16vAz5Q" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="joKIuwHXqEeNGZD1Dgg7dw" visible="0" canBeVaried="0" />
-                        <Parameter id="NyX-sTnwoUyxnjRBFLTOHA" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="X3-_AUN2Ukadv7469fGvkg" visible="0" canBeVaried="0" />
-                        <Parameter id="vG4TOZF13EKLkbNGSeQB_g" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="wr-g10h8YEa8K25XS38bHw" visible="0" canBeVaried="0" />
-                        <Parameter id="7IfcN_KBU0-AnZ-skek1Hw" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="O4uXq9fcQUOOjOIOSBebzQ" visible="0" canBeVaried="0" />
-                        <Parameter id="lUCAZGyWLkmwiZ6kzkbqzQ" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="8a_4Ku7qeU2ET4MTsuq1eg" visible="0" canBeVaried="0" />
-                        <Parameter id="qKoNYPvx_EO20e99k-obGQ" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" visible="0" canBeVaried="0" rHSFormula="tk4SCA3cmUqcJk5RnR57SQ" value="0" displayUnit="µmol" />
-                        <Parameter id="wfL15SOB9U6kwyPk0NLKmQ" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="YPcDU6OflUK1GsshCttR_g" visible="0" canBeVaried="0" />
-                        <Parameter id="V6Crg7NRVEWMwL-pAp6phw" name="Solubility" description="Solubility" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" formula="dmsldFy_d0yxW1F99kczwg" visible="1" canBeVaried="1" displayUnit="mg/l" />
-                        <Parameter id="7SOo0kgdJkCXaS685B0sSw" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="1mqdNKpEUkyjrQ2u-b6LhQ" visible="0" canBeVaried="0" />
-                        <Parameter id="UtX1UHM_e0CcpoSE24NwUw" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="q9ONV7JhAUmz3JIZXXMtaQ" visible="0" canBeVaried="0" />
-                        <Parameter id="_L8PbaL4Gkiq52IONSzWSQ" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="MzLD1RbN0E2gWRS1tXcKXQ" visible="0" canBeVaried="0" />
-                        <Parameter id="LdYSyRh36km392IQvqIszw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="0" value="1" />
-                        <Observer id="DpY4ynQhPU-vzbVoPDEEDQ" name="Concentration in lumen" description="Concentration of the molecule in lumen" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="HLIRXIitt0KZivKUJbxfRQ" displayUnit="µmol/l" />
-                        <Observer id="EtocigzBh0K_ZSX_DnqoUg" name="Fraction of oral drug mass absorbed into mucosa segment" description="Fraction of oral drug mass absorbed into mucosa segment" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Drug, Observer" formula="XKRnaHqlW0S6GDKupu_dRA" />
-                      </Children>
-                    </MoleculeAmount>
-                  </Children>
-                </Container>
-                <Container id="FF0ppGi5GkaCMtFrfbD1kA" name="ColonSigmoid" description="Colon Sigmoid / Distal Colon 2" icon="ColonSigmoid" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Lumen" />
-                    <Tag value="LumenSegment" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="dKuhR2z62EWOCHGQLT0Nkg" name="Thickness of gut wall" description="Thickness of Gut Wall" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="PqZQXUcR2EuAADd5-fG5VQ" visible="0" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="drJ5GAV8okS01DM-TLYRfA" name="Absorption of liquid" description="rate of liquid outflow" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="raaPAu1fU0iAAnp-w64zew" visible="0" canBeVaried="1" displayUnit="1/min" />
-                    <Parameter id="_ArH5UcUxUOW2jtMAcwDhA" name="Distal radius" description="Distal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="F2HrUeP5gUqsHUmUBhdDeQ" visible="1" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="JcY2ZiWG4kmwbniZIZW9fA" name="FillLevelFlag" description="Fill Level Flag" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="_fdpBznEC02u7-tLvw5OGQ" visible="0" canBeVaried="1" />
-                    <Parameter id="b0PgUCHK6k-E3VQum90NAA" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="OyHn7MCeuk6vmTKdv-iJqA" visible="0" canBeVaried="1" />
-                    <Parameter id="WXI47IgDTU-Ig2QXR6Nsiw" name="Geometric surface area" description="Geometric surface area of GI segment" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="9EhmHSAXZ0OXYPaSstfWrQ" visible="1" canBeVaried="1" displayUnit="cm²" />
-                    <Parameter id="S95lUJnsvU-D4NB3v6PnQg" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="h5T7bksqM06EslDPAaJ2WA" visible="0" canBeVaried="1" displayUnit="1/min" />
-                    <Parameter id="T_FdVPra90WtwrcmpG2NMQ" name="Length" description="Length" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="oHVl-7jv2UWh9dAin2b_Tg" visible="1" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="1O7kPmcjGE-kXhs0uZNgrQ" name="Liquid" description="Liquid" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="2aVY-_-FqE6bH8tHqQryGA" visible="0" canBeVaried="1" rHSFormula="M8B1FjdsN06uE0D4iKM36w" displayUnit="l" />
-                    <Parameter id="P28P6FamjEatgwwBuQcUUg" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="iBhnMkyDG02aBOWLVQkpnQ" visible="0" canBeVaried="0" displayUnit="l/min" />
-                    <Parameter id="LG08Tm_Vzkq8qAwLpsAs7A" name="Proximal radius" description="Proximal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="qXWNXa9UNUq30PzJeA1etg" visible="1" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="aYvWgr_OpUKC3DPZI0W9wA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="cXeVNOGhxUGjgGD8PwjALA" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Parameter id="gCsBFfjOT06NmFBdPDplEg" name="Volume (gut wall)" description="Volume of the gut wall" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="GevFGp6Z5UaiGEpJ99y0bg" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Parameter id="dmxA9RkRT0q3GZGoLIs75w" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="4zDI9Pf-X0CuhIbN_Sob5g" name="Secretion of liquid" description="Rate of liquid inflow" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="jq52RNCp9E6CRl075YyMbQ" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="AEkoCvP59k-m7fbb6mGhWA" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0384322177" displayUnit="cm" />
-                    <Parameter id="Gu3gypUEAkWlMJVKvjpCbQ" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.0889014" displayUnit="1/cm" />
-                    <Parameter id="jJfRDxeyHkK9Jribd0d2TA" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0274432593" displayUnit="cm" />
-                    <Parameter id="-pIAk0o6kUa4C4szwob30g" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.00536" displayUnit="cm" />
-                    <Parameter id="lxhezwRw9EOpOvySIGlGXw" name="Intestinal transit rate" description="Transit rate along intestinal segments" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" visible="0" canBeVaried="1" value="4.0741" displayUnit="1/min" />
-                    <Parameter id="iw9RZb8fRUOZx8144HPI2w" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.008955843" />
-                    <Parameter id="_8U7c9gF20K_TNFozzp3XA" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0384322177" displayUnit="cm" />
-                    <Parameter id="pBejKZ0JmkCjkSeWmWZhxg" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="6.6" />
-                    <Parameter id="QHDzv3Gt8EqmPIKSzd6i7w" name="Microvilli factor" description="Microvilli factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                    <Parameter id="RUzqP_PeDUehbL20fEjNKA" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.121300709" />
-                    <Parameter id="41CDMkq7bEO2gQe-A4wfDw" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.008955843" />
-                    <Parameter id="SwnCnI7YvkelDnXBCl1NLQ" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5337898629" displayUnit="cm" />
-                    <Parameter id="FtMo2B0MakaJ3crXIVk4yQ" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0060009" />
-                    <DistributedParameter id="WBmWWAzZ6ku0V6KyLUCY3Q" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="fQ_fmAtHu0-4pi9fov9Obg" mode="Logical" visible="1">
-                      <Children>
-                        <Parameter id="0JHaGevkxUygvc36LHDmdA" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                        <Parameter id="sKXqM6nsZ0C6nJamIlfqog" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="2.5" />
-                      </Children>
-                    </DistributedParameter>
-                    <MoleculeAmount id="jIGCgtwn-U2Oqcv2W4G-ZQ" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                      <Children>
-                        <Parameter id="jhNY2CQ7qE-2Ew3N67PteQ" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                        <Parameter id="vSGCDoUwVkehmiDU1quE8A" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="vCrIzy5_1ESqvBhRLXpF5w" visible="0" canBeVaried="0" />
-                        <Parameter id="cchXTpVP3k-bQulnflivUA" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="aaN0oRlL0UqJCGPBHAdxDw" visible="0" canBeVaried="0" />
-                        <Parameter id="5EE7ZEXQnEitZeaaGKdVcQ" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="jqOKh9IlDUuPjU07LUJpfw" visible="0" canBeVaried="0" />
-                        <Parameter id="x3999iR1wkCiCg4ywNYv4g" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="K51DMgiyp0O_ti_JBCqZiA" visible="0" canBeVaried="0" />
-                        <Parameter id="HpSfxMfzPUmXd8cES5iryg" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="vWnVVEuk10u2Oc9kqs8o2g" visible="0" canBeVaried="0" />
-                        <Parameter id="MbFIiM6SkU29YISXcnnkOA" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="GNl4uLnLQUSCNrBQn2GtTg" visible="0" canBeVaried="0" />
-                        <Parameter id="NwK0RFDGmku79Qt7fKg3gQ" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="uVhmAX8O90GvrGE-UBfiUQ" visible="0" canBeVaried="0" />
-                        <Parameter id="YqeBEfNTWEe54pG1t87_EQ" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="dnS4R2rmakujlz83K7Y7zg" visible="0" canBeVaried="0" />
-                        <Parameter id="vusN9vdFYEWieIFC8Cz2zg" name="Solubility" description="Solubility" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" formula="iEysIT7pcEGHRyJCNrRRMQ" visible="1" canBeVaried="1" displayUnit="mg/l" />
-                        <Parameter id="WDCUDQg7VkW1lyB6awvbHw" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IRp0ios9aEexciHVsGsvnQ" visible="0" canBeVaried="0" />
-                        <Parameter id="Gijf6NcUBEK7SHmpA9tFXQ" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="2J5XUvx2dEWLL2V6an6ztg" visible="0" canBeVaried="0" />
-                        <Parameter id="7ayfcuRetkOSt13WJfvtSw" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="qz67lpAOAE6kLKaQJsJyKQ" visible="0" canBeVaried="0" />
-                        <Parameter id="oLYAyxbcSUKThuiBC0gjHA" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" visible="0" canBeVaried="0" rHSFormula="2W0GQs4Ki0Kh34mPKysMOg" value="0" displayUnit="µmol" />
-                        <Parameter id="wPSDxr8HgE6U0F2L5yDljQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="0" value="1" />
-                        <Parameter id="CupTlPWILkO1kDHOtsGuMQ" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="-Iqdttfh00GvQTYfUseLhA" visible="0" canBeVaried="0" />
-                        <Observer id="o8NlG7Y0RkaLuPYPph25GA" name="Concentration in lumen" description="Concentration of the molecule in lumen" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="HLIRXIitt0KZivKUJbxfRQ" displayUnit="µmol/l" />
-                        <Observer id="WukqIbmbQUq1Awn7RG2Y1Q" name="Fraction of oral drug mass absorbed into mucosa segment" description="Fraction of oral drug mass absorbed into mucosa segment" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Drug, Observer" formula="XKRnaHqlW0S6GDKupu_dRA" />
-                      </Children>
-                    </MoleculeAmount>
-                  </Children>
-                </Container>
-                <Container id="eprwABQUEkOQApydkOYKug" name="Rectum" description="Rectum" icon="Rectum" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Lumen" />
-                    <Tag value="LumenSegment" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="FahMX3bmukGp8avTD38Ymw" name="Length" description="Length" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="oHVl-7jv2UWh9dAin2b_Tg" visible="1" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="D4VtC_GPt0ilv4sJ6gihzg" name="Absorption of liquid" description="rate of liquid outflow" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="OkubLRgciUe2vrc8xQTUHA" visible="0" canBeVaried="1" displayUnit="1/min" />
-                    <Parameter id="s3HnxPcx4UmyuqH6BWELOg" name="Distal radius" description="Distal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="F2HrUeP5gUqsHUmUBhdDeQ" visible="1" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="j4gZ5CjG8EuvZ9EQwgQhMA" name="FillLevelFlag" description="Fill Level Flag" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="_fdpBznEC02u7-tLvw5OGQ" visible="0" canBeVaried="1" />
-                    <Parameter id="MvL5YrO5Jk-bZa2nR5L6mQ" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="OyHn7MCeuk6vmTKdv-iJqA" visible="0" canBeVaried="1" />
-                    <Parameter id="BPsX9RL8MECAX_C-0fEPBA" name="Geometric surface area" description="Geometric surface area of GI segment" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="9EhmHSAXZ0OXYPaSstfWrQ" visible="1" canBeVaried="1" displayUnit="cm²" />
-                    <Parameter id="SmVapyFxAE2cZukA06R-YQ" name="Liquid" description="Liquid" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="2aVY-_-FqE6bH8tHqQryGA" visible="0" canBeVaried="1" rHSFormula="LVKmAVLS3kyx6PYjgl2laQ" displayUnit="l" />
-                    <Parameter id="Dz9zpRl5AUqoJMwfdPMxUw" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" formula="8Zf7paM7GEqDexdM2sLUsg" visible="0" canBeVaried="1" displayUnit="1/min" />
-                    <Parameter id="OiXoq9xitEaVymZDZr1SHw" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Zgl8t2xXbkagziKqPp0F1Q" visible="0" canBeVaried="0" displayUnit="l/min" />
-                    <Parameter id="WgaRMvU_PU2GkxwDHwYrsg" name="Proximal radius" description="Proximal radius of intestinal segment" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="qXWNXa9UNUq30PzJeA1etg" visible="1" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="k_0xd1R48UOcraB3dMXbzg" name="Secretion of liquid" description="Rate of liquid inflow" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Nw59eaXM8EmeT6fOWisWXQ" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="1Km4-YXNbkS1WMpJD8LTZQ" name="Thickness of gut wall" description="Thickness of Gut Wall" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="PqZQXUcR2EuAADd5-fG5VQ" visible="0" canBeVaried="1" displayUnit="cm" />
-                    <Parameter id="TK1RCKE4vk6N3G9A6uwmXw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="cXeVNOGhxUGjgGD8PwjALA" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Parameter id="eME_d88Zz06oOfED4VFrDw" name="Volume (gut wall)" description="Volume of the gut wall" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="AFLVjEqIMU60X67nq3PZaQ" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Parameter id="P15bPF7_BkCJBNGgK5Rozw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="UZSrwxoVjUmtv0SU4f_3Ww" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0060009" />
-                    <Parameter id="Ej8bEDRle0GtPorZg_FQdw" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0324721331" displayUnit="cm" />
-                    <Parameter id="0UjwLbjNjkCrKtGVgxYOFw" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.00665" displayUnit="cm" />
-                    <Parameter id="HefeOmAol0SlobO6k9XhBw" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.005597402" />
-                    <Parameter id="AFvYLprKJE6IfdOmNn5XTA" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0240201361" displayUnit="cm" />
-                    <Parameter id="_1xJmz82Dk-C_3Afl8mhUQ" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.008955843" />
-                    <Parameter id="pOPcAMRcz06XrtM_GGc0TQ" name="Intestinal transit rate" description="Transit rate along intestinal segments" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" visible="0" canBeVaried="1" value="315.618" displayUnit="1/min" />
-                    <Parameter id="Qi-3tPgEtkCH4cN1fXj5_Q" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.1569046761" displayUnit="cm" />
-                    <Parameter id="ihq-qNM3EEiYmMlExyE_5w" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="6.6" />
-                    <Parameter id="tycU23bIikGzv3xD6WroXQ" name="Microvilli factor" description="Microvilli factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                    <Parameter id="6Kmt5PoE-UO8shzIrof8aQ" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.052420808" />
-                    <Parameter id="eqTWpICfJEi-Y2t6H9gN2g" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0384322177" displayUnit="cm" />
-                    <Parameter id="JxUQMgK5OEOsr3kilJ1hKg" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" visible="0" canBeVaried="1" value="-0.10014267" displayUnit="1/cm" />
-                    <DistributedParameter id="tdrm3008BkCsYfxN0Q5CHA" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="bW0caNHwPE6bBQPsJKXbHw" mode="Logical" visible="1">
-                      <Children>
-                        <Parameter id="zm0Kn8luAUKkU89ddUwg9w" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" />
-                        <Parameter id="fKaEC3XwY0iAKz-XZqcahQ" name="Mean" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="3.56" />
-                      </Children>
-                    </DistributedParameter>
-                    <MoleculeAmount id="2kdpKYdY3EeBvJPRNS1TEg" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                      <Children>
-                        <Parameter id="A77J11ojk0u8coRdZa8oZA" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                        <Parameter id="E_0z0GLADEaJoWyzizyYMQ" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" visible="0" canBeVaried="0" rHSFormula="eCNj3MGCBEGCC0nhjiAtHA" value="0" displayUnit="µmol" />
-                        <Parameter id="p6f6SevTEEOZAZe9pv0AJQ" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="HMWrXvoT3kWsXDm0zf_q5Q" visible="0" canBeVaried="0" />
-                        <Parameter id="TPwhhRFSqkeVHNgH_iqtZA" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="lNQIrs-5UUmtEexY-1b-0A" visible="0" canBeVaried="0" />
-                        <Parameter id="lGuGXv-K3Uq85NEKyAhpzA" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="uIBkAdyujU60-QX3lyPGtw" visible="0" canBeVaried="0" />
-                        <Parameter id="lb7HARi3YU6D2_2JbqPMOw" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="o3P3Evx3Y0abEPPGp6n5lA" visible="0" canBeVaried="0" />
-                        <Parameter id="mwEBahufakaiumVsRLH8rw" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Ggh_jGKflk2w3FlpgCwW9w" visible="0" canBeVaried="0" />
-                        <Parameter id="X_cLAtDnCk6FVAlallAGug" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="eqTHTeezfk2KS_9y10vH3w" visible="0" canBeVaried="0" />
-                        <Parameter id="yfRRRPZdFEuGW7AE8jm94Q" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="AAjrdnlysUehsM8CRxXN_A" visible="0" canBeVaried="0" />
-                        <Parameter id="_YZ-8nVuOU-rAEE1GlLkyQ" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="fgkcbOf4pkWdjtjOQKF2Gw" visible="0" canBeVaried="0" />
-                        <Parameter id="UHLSYFf6LkySV1JFEcxnng" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="daIx8UNeRUWs1kDNBzCufQ" visible="0" canBeVaried="0" />
-                        <Parameter id="Vt2UEovxLE-WkByUwh2QcQ" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Bb32SDfj6ka88Bp0I8jZZA" visible="0" canBeVaried="0" />
-                        <Parameter id="UctLCgYcFECpgImusIiyuA" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="SuX8N0IGOEmDia5VOBtLhQ" visible="0" canBeVaried="0" />
-                        <Parameter id="GvJvPT_ZQ0GUgYJAEDNU_g" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="TsRo45A9iUWUlN00TRmT1A" visible="0" canBeVaried="0" />
-                        <Parameter id="PEIodOI7DkGJvTwdHrimIA" name="Solubility" description="Solubility" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" formula="S_LulL1ig0KPBgGaPL0Hfw" visible="1" canBeVaried="1" displayUnit="mg/l" />
-                        <Parameter id="iIP41J6E0UivZgjVZ09hMg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="0" value="1" />
-                        <Observer id="Sw6TsOz01E2kXZOK6ctDFA" name="Concentration in lumen" description="Concentration of the molecule in lumen" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="HLIRXIitt0KZivKUJbxfRQ" displayUnit="µmol/l" />
-                        <Observer id="OFmjPYzLQEuh0om3M2Em_w" name="Fraction of oral drug mass absorbed into mucosa segment" description="Fraction of oral drug mass absorbed into mucosa segment" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Drug, Observer" formula="XKRnaHqlW0S6GDKupu_dRA" />
-                      </Children>
-                    </MoleculeAmount>
-                  </Children>
-                </Container>
-                <Container id="IT6A3BRgbUSfIKDt5ltCRQ" name="Feces" description="Feces compartment used to collect the fraction excreted of the compound from the instestinal wall into the gut lumen." mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Lumen" />
-                    <Tag value="LumenSegment" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="i8UulqvsqkOXZ2W2Ug2MZw" name="Liquid" description="Liquid" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" rHSFormula="k6Bb2dhGoU-z1Sei7QSt6w" value="0" displayUnit="l" />
-                    <Parameter id="MoBxXwEdqUqxy6-zRJhquA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="l" />
-                    <MoleculeAmount id="wdk5emL920WOkPCvQGJU-Q" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                      <Children>
-                        <Parameter id="RwwtYWukoUKfx0VfepAqKg" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                        <Observer id="3Las4v9LbEqTIRCrP-SO7w" name="Concentration in lumen" description="Concentration of the molecule in lumen" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="HLIRXIitt0KZivKUJbxfRQ" displayUnit="µmol/l" />
-                      </Children>
-                    </MoleculeAmount>
-                  </Children>
-                </Container>
-                <Container id="A3v4uR5jnUmP7a51KlJqig" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Observer id="29RZE8OlZUWtE2XQedjj2g" name="Fraction dissolved" description="Dissolved fraction of all oral applications" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Drug, Observer" formula="U5HrEIDfqkaw59Ts5YKoYw" />
-                    <Observer id="RwAAFNK-mUyU7kOF0VFoBg" name="Fraction of oral drug mass absorbed into mucosa" description="Fraction of oral drug mass absorbed into mucosa" persistable="1" isFixedValue="0" dim="Fraction" quantityType="Drug, Observer" formula="HJpEilfGvUWWOhQMQNbNHQ" />
-                  </Children>
-                </Container>
-              </Children>
-            </Container>
-            <Container id="Ye7ydHvGlUCivOdhatm4Dw" name="Stomach" description="Stomach" icon="Stomach" mode="Logical" containerType="Organ">
-              <Tags>
-                <Tag value="Portal Vein Supplying Organ" />
-                <Tag value="TissueOrgan" />
-              </Tags>
-              <Children>
-                <Parameter id="ZAr0OOkhn0Wxvl0KGaULsA" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="uSjt8LuoBUu75Z4-7ZUOCw" visible="0" canBeVaried="1" displayUnit="kg" />
-                <Parameter id="sX7Bpv-daUS55PRxKYV93A" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="CBHG2JXCvUaDcO6ZoidROA" visible="1" canBeVaried="0" displayUnit="l" />
-                <Parameter id="-9LoKh9C3Uie6KZijC1A_Q" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="irnuxqjV80Kt6IZmjMD02g" visible="1" canBeVaried="1" displayUnit="l/min" />
-                <Parameter id="KccI3g0NpUq1cKrfasGm5g" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="NMJACUQWYkOxmQ9OpiZ5Kg" visible="1" canBeVaried="1" displayUnit="l/min" />
-                <Parameter id="QWpRweUMwU6haE5eCchplQ" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="LSHvGCmOBEascdPo-Ab-KQ" visible="1" canBeVaried="1" />
-                <Parameter id="DqsHdBHjv0a7fAVMD-Wm1Q" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="jdhhCNoMYE-s118HG9XzZw" visible="1" canBeVaried="1" displayUnit="l/min" />
-                <Parameter id="1wg2ZYgg80KPerfANuHqvQ" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                <Parameter id="X1BaqFBOyUWOxMVhww_CRQ" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.75" />
-                <Parameter id="0e6lGRW-T0WtUyDU_ApPUg" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                <Parameter id="YjgTmciRM0eaafhfLhwf8A" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="4.5E-08" displayUnit="µm" />
-                <Parameter id="oAW31AnlAkO1ETxmeNO55A" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="2.5E-07" displayUnit="µm" />
-                <Parameter id="MKm0SkjCeU-TRBznvTNL6w" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" visible="1" canBeVaried="1" value="3.97222222222222E-11" displayUnit="ml/min/N" />
-                <Parameter id="DDEMkCrHRUWLLibzTRXNRg" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.05" />
-                <Parameter id="8x9dbMaRMUSrRq320vgBvQ" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0487" />
-                <Parameter id="5JXyUO8HCkKLDC9l3-NdgQ" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.062" />
-                <Parameter id="TVU9jV-Ve0qTcYvmP87-VQ" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.032" />
-                <Parameter id="3iRY9zlJm0K4oLQ8kaMNrg" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.133" />
-                <Parameter id="egd2Om5XvE2D_2819JnWrw" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0163" />
-                <Parameter id="K8eqQC8huE64Ot2tqPBcPQ" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.718" />
-                <Parameter id="aW6MvItOqU6_iJWyoR4XXQ" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.792" />
-                <Parameter id="3vcHfJFALEKmIAeEKFlYHg" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.158" />
-                <Parameter id="kMLFoB_UD0qlLM-SghC7mg" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.141" />
-                <Parameter id="3T0RLTtzXUSK9DcFffxSHw" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-                <Parameter id="eUPY_8fcAUOt2NxZvd9mGw" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.1" />
-                <Parameter id="Zlv86t9nJ0SSoQPcZKXU0g" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0483" />
-                <Parameter id="-imr3sUWzkK0_EmWNfbvBA" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0375" />
-                <Parameter id="5CAWpr9Z30yyMc_pn7ef2A" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0182" />
-                <Parameter id="7xMuH4fmYk6iwyyfAD_vZw" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0124" />
-                <Parameter id="cOrwAZsfcUeJM0L6XglfIQ" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.282" />
-                <Parameter id="_KDRgE8bjUSpxpD3NRgTcA" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.15" />
-                <Parameter id="wLZmpojuQUenrz8bioHm3g" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.78" />
-                <Parameter id="kjDSuplv1EqZZL1MF1D2Pg" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.456" />
-                <Parameter id="8UXrqfYhCEGMTFIs9DeB3Q" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0035" />
-                <Parameter id="KfpbS329_0GRpNdFx6DGBg" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="2.41" />
-                <DistributedParameter id="pD4EeyfQWkerD_EVlD4sww" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="6eH10_SmsESeN5bZVK5EAQ" mode="Logical" visible="1" displayUnit="l">
-                  <Children>
-                    <Parameter id="J7zWPdI8HEy6Z5qKmQLvLw" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.500397173769471" displayUnit="l" />
-                    <Parameter id="BHuDOYsjeEG3vlXtK4Ix1g" name="Mean" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" value="0.135729408786912" displayUnit="l" />
-                    <Parameter id="9_d66WYmOUalxA7BV01ubg" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0203594113180368" displayUnit="l" />
-                  </Children>
-                </DistributedParameter>
-                <DistributedParameter id="w4ml2iPvmk2qX8KFzPtL-A" name="Specific blood flow rate" description="Blood flow rate normalized to the organ volume" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" formula="7xzCdlrWjk-UEhfkF6thTQ" mode="Logical" visible="1" displayUnit="ml/min/100g organ">
-                  <Children>
-                    <Parameter id="0TUaU8NUik-vf09Pvj7M-A" name="Percentile" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.5" displayUnit="ml/min/100g organ" />
-                    <Parameter id="_Vf6sW3KdUOtX1rZASH5uw" name="Mean" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" visible="0" canBeVaried="1" value="0.3861" displayUnit="ml/min/100g organ" />
-                    <Parameter id="ZbYAO0fe1EaAuATQqfJ7xw" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" visible="0" canBeVaried="1" value="0.019305" displayUnit="ml/min/100g organ" />
-                  </Children>
-                </DistributedParameter>
-                <Container id="HZ6pfKhao0S84LcP_vvjSQ" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Portal Vein Supplying Organ" />
-                    <Tag value="Stomach" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="yOelcv9t0kCeiAW3cq8Rlg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="7yQUuRlEDUOwUcAfuDoj7A" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="AWSLB9BqIUm588s01h4uMw" visible="1" canBeVaried="1" displayUnit="l" />
-                    <MoleculeAmount id="bgD3avhorEm8i92Um2o6Mw" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                      <Children>
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-                  <Tags>
-                    <Tag value="Portal Vein Supplying Organ" />
-                    <Tag value="SmallIntestine" />
-                  </Tags>
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-                    <Parameter id="I3QPPhWYE0WQfHrmI6c_Vg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="2znHM-7hCESyDJPFkFbbsw" visible="1" canBeVaried="1" displayUnit="l" />
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-                <Container id="BO_2kdQ94EefqAdvRA1T2Q" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
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-                    <Tag value="SmallIntestine" />
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-                        <Parameter id="yZw44ZddH0OeRxQ0tkfdvg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="u_vIomo5MEK8iZ9FLpyKPQ" visible="0" canBeVaried="0" />
-                        <Observer id="sisTFiR8ykysSq6Dh7jRqA" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
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-                  <Tags>
-                    <Tag value="Portal Vein Supplying Organ" />
-                    <Tag value="SmallIntestine" />
-                  </Tags>
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-                    <Parameter id="hZxkoAjNFUm9F2PxnhsS8g" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="YcDySoEECUCkabMfcgVuzw" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="vZFoq2eOvkSRqULXh96lvw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="Ue-GxIfM90qPHZMmN2fUlw" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Parameter id="Hed2JzeHx0KTlwrJNZnHJw" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.4" />
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-                        <Parameter id="UkyUmXnSE0i2nugdQJGTxA" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                        <Parameter id="k0_5Bf45TkqojesZprb-xw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="ZN6lG_Ebx06vADepLGc0tA" visible="0" canBeVaried="0" />
-                        <Observer id="ZgSSw3nnl0SfP38ELcZVhA" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
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-                      <Children>
-                        <Parameter id="D8KQXmJRcU6mz1dXNzZaQg" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="uSjt8LuoBUu75Z4-7ZUOCw" visible="0" canBeVaried="1" displayUnit="kg" />
-                        <Parameter id="nAjAe0_UL0CFbinyd65AQw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="LEwTV4qfP0OlLU7itHSbkA" visible="1" canBeVaried="1" displayUnit="l" />
-                        <Parameter id="U1i8vDNMyEynpYa4ZbUrjw" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="Gjt25Z3wS0ulOtVbHUeTPg" visible="1" canBeVaried="0" displayUnit="l" />
-                        <Parameter id="pRToj5-K00qu7_bKGwohsA" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="et1rku1VQkqZCxraRd0LsA" visible="1" canBeVaried="1" displayUnit="l/min" />
-                        <Parameter id="hunF4gHmI0athAprfNZo9A" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="NxoV47Ql00aifPKqk7nOJw" visible="1" canBeVaried="1" displayUnit="l/min" />
-                        <Parameter id="7BZIc8W7LEWpc4f6lqGybA" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="cDO00dCgEUa1Rf_VnhA32g" visible="1" canBeVaried="1" displayUnit="l/min" />
-                        <Parameter id="l9Ur1t2v9ku9FAONaltcGA" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="LSHvGCmOBEascdPo-Ab-KQ" visible="1" canBeVaried="1" />
-                        <Parameter id="37qQbg8kJEWr_P79ZSnZ_A" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                        <Parameter id="8FLkOmcq8UClOkgBVyhdvA" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                        <Parameter id="1WdLyPzu3ECuPgVfU79gCw" name="Fraction of regional blood flow rate" description="Regional blood flow fraction supplying the mucosal tissue of the segment" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.093" />
-                        <Parameter id="hx4477ldrEuEIxRg1ie6Ng" name="Fraction mucosa" description="Mucosal fraction of regional intestinal tissue mass" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.26" />
-                        <Parameter id="XOD_X9KaiE-vddY_M8U3tw" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" visible="1" canBeVaried="1" value="1.53888888888889E-10" displayUnit="ml/min/N" />
-                        <Parameter id="rXSm6o3-z0-ZZiiBcpQo9g" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="2.5E-07" displayUnit="µm" />
-                        <Parameter id="1O0mOwHycE68LyIEb_BnHw" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.05" />
-                        <Parameter id="xeI97SBKbEW9QStixbfPxA" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="4.5E-08" displayUnit="µm" />
-                        <Parameter id="rjBebaWyrkqink6aeZQ3mg" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.06" />
-                        <Parameter id="juoMvfbTk0ej0sVVF9OlKA" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0487" />
-                        <Parameter id="ZVf_kfeOMEyLDMFKwHOkRQ" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.13" />
-                        <Parameter id="7PqTebMr5EmiXIrDCu9fnA" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0163" />
-                        <Parameter id="FWbU_ulnZ0CpmK0wZPk9LQ" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.08" />
-                        <Parameter id="YgUuJlVjtEqj6xYcszo6-Q" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.158" />
-                        <Parameter id="UGiiQo6sSkeO-w2sMhwD9A" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.141" />
-                        <Parameter id="A-aAvRSQLEiWXNFPCvzj5Q" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-                        <Parameter id="Sykm4E6CJEauQXxVgQrJ9w" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.718" />
-                        <Parameter id="Azo_KpS7lU-hrRq_pjpA6w" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.8" />
-                        <Parameter id="f8U8SGuYW0afVR7aUafmFg" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.42" />
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-                        <Parameter id="dcuVkGCZVkeJc9ffWC5-Fg" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0124" />
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-                        <Parameter id="XpRQ3W26iEqvk94kPDNZqw" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="2.41" />
-                        <Parameter id="yE2XuyllIUGuAIb3-NRaJg" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0035" />
-                        <Container id="5qa_dNfzPEqENSftAboAkA" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Duodenum" />
-                            <Tag value="Mucosa" />
-                            <Tag value="SmallIntestineSegment" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="XdG4LdZR2Eez6UX2-CUStQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="UN53LMBerEWejPLn3wJCJQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="AWSLB9BqIUm588s01h4uMw" visible="1" canBeVaried="1" displayUnit="l" />
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-                                <Parameter id="zk-Anpflt0OM4wrSb0x37g" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                                <Parameter id="tOqAgFa_N0eBvBKQSSvS_w" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="jq9rwlKf70-gdm8c2FOCHQ" visible="0" canBeVaried="0" />
-                                <Observer id="xhAAuh0eKEmfiNlr8xakzg" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
-                              </Children>
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-                        <Container id="TdV1_un1aESakxFEr6GkQw" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Duodenum" />
-                            <Tag value="Mucosa" />
-                            <Tag value="SmallIntestineSegment" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="61b9F_7o70ChZ9WnM1xXZQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="DFb9vsRH1kChNcVr3hHd7A" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="bFSKBq9P6ESwCQ7kJZpF0A" visible="1" canBeVaried="1" displayUnit="l" />
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-                              <Children>
-                                <Parameter id="VFAbr_GcRkyA9ospuzOV_A" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                                <Parameter id="OZAbtKMrcE6W4dJQdw2v9Q" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="SP-USg-WBUmt6v_dRgolcg" visible="0" canBeVaried="0" />
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-                              </Children>
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-                          </Children>
-                        </Container>
-                        <Container id="qdfrt7fje02lpLnQb4CGDw" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Duodenum" />
-                            <Tag value="Mucosa" />
-                            <Tag value="SmallIntestineSegment" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="a0F1kyVbWkWbeZc6QNphdQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="xon0ziiVA0utJYWwvIHEMA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="5D8ZOzXK7EGOwj3jJsZ67w" visible="1" canBeVaried="1" displayUnit="l" />
-                            <Parameter id="XHlUadGVJUClSCL5BUNdRA" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="mmPlMPjMnECVqmG5mkXJMw" visible="1" canBeVaried="1" />
-                            <MoleculeAmount id="fg-dyqp9w0KRdVpmwPAxnw" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                              <Children>
-                                <Parameter id="RlltidxiEkWbeYhxcCscrA" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                                <Parameter id="NNXpvcvJtkqu9ODzZW0pzQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="GDiNoHTX_kq4gWMn4xyfXQ" visible="0" canBeVaried="0" />
-                                <Observer id="gBKUr6oes0u6o5xm-Dz74Q" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
-                              </Children>
-                            </MoleculeAmount>
-                          </Children>
-                        </Container>
-                        <Container id="34MfH5c9wEKhN-FvYBmvow" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Duodenum" />
-                            <Tag value="IntestinalSecretionSource" />
-                            <Tag value="Mucosa" />
-                            <Tag value="SmallIntestineSegment" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="hbVnDgZepkKTCIpmHCV_NQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="dE28EI6hVk23fUjk1luoMw" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="o1aUnFQazUyg1R1Gq4TXLA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="m5gWJCaKR0mYkdrFJN9OsQ" visible="1" canBeVaried="1" displayUnit="l" />
-                            <Parameter id="7jYS_krRZEeUp2SIGNUfog" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.3" />
-                            <MoleculeAmount id="OmmrIkIo20K9O_8M3GTn6Q" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                              <Children>
-                                <Parameter id="CVK6OXAt4kGOH5lWGJj77g" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                                <Parameter id="I3attplpzki7htmJ7DcfEg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="ChmPga5ht0mpWfM3jBqM6Q" visible="0" canBeVaried="0" />
-                                <Observer id="a4lu8jKHPEW9NWKqeGrLqw" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
-                              </Children>
-                            </MoleculeAmount>
-                          </Children>
-                        </Container>
-                      </Children>
-                    </Container>
-                    <Container id="lD9xl73A0kmx7LSxywSrPQ" name="UpperJejunum" description="Upper Jejunum" icon="UpperJejunum" mode="Logical" containerType="Compartment">
-                      <Children>
-                        <Parameter id="o7OFMsDzcUqA3lsyuyDHbA" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="uSjt8LuoBUu75Z4-7ZUOCw" visible="0" canBeVaried="1" displayUnit="kg" />
-                        <Parameter id="MFiW7RmTsUa1fa9U3BhrpQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="kgDIgONbXkqnjbETwU5R_A" visible="1" canBeVaried="1" displayUnit="l" />
-                        <Parameter id="hmwMonK5JEarrbvj8Kr2Qg" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="et1rku1VQkqZCxraRd0LsA" visible="1" canBeVaried="1" displayUnit="l/min" />
-                        <Parameter id="VydrkZ3PqEi2EMb4VD4hcw" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="YR0X7Z-NMEyBlSl8AIu6OA" visible="1" canBeVaried="0" displayUnit="l" />
-                        <Parameter id="s9GHNl3Jf0iof2pinoQJBQ" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="NxoV47Ql00aifPKqk7nOJw" visible="1" canBeVaried="1" displayUnit="l/min" />
-                        <Parameter id="BcFxDYH7z0C_sWSfCsgvCg" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="cDO00dCgEUa1Rf_VnhA32g" visible="1" canBeVaried="1" displayUnit="l/min" />
-                        <Parameter id="GIvP_IuR4E2b_ZcJEcAVJA" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="LSHvGCmOBEascdPo-Ab-KQ" visible="1" canBeVaried="1" />
-                        <Parameter id="PSRVYuWbZUWEWYRst5gFvA" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                        <Parameter id="DvSucqaFcEO_qdyeMBj1Fg" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                        <Parameter id="fgKXvGVLuEGLXjSKj4qAfQ" name="Fraction mucosa" description="Mucosal fraction of regional intestinal tissue mass" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.26" />
-                        <Parameter id="44nzZX9x3E-cygDfZKdiGA" name="Fraction of regional blood flow rate" description="Regional blood flow fraction supplying the mucosal tissue of the segment" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.219" />
-                        <Parameter id="Stdh4QnSLkGt_ARfZ5qnkg" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" visible="1" canBeVaried="1" value="1.53888888888889E-10" displayUnit="ml/min/N" />
-                        <Parameter id="VlUcyQZKrEeYXrYIp7CNrg" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.05" />
-                        <Parameter id="WTmfJ50uyEm0tn2Vgq05uA" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="4.5E-08" displayUnit="µm" />
-                        <Parameter id="znI09G-AAkyAD81UW5zr2g" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="2.5E-07" displayUnit="µm" />
-                        <Parameter id="qNCKBLNBhEqNiBr0sZFqGA" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.06" />
-                        <Parameter id="Er1kNNcfPkuBwPAlQs002Q" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0487" />
-                        <Parameter id="jBWtfuDqWkK1cx25BWz_Rg" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.13" />
-                        <Parameter id="oFR4nOXk6k-XooGxVBKcmA" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.08" />
-                        <Parameter id="1KN1Zs87e0GGtVUerfqCAA" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0163" />
-                        <Parameter id="FWHyocoYIEm0kbvcsZamQA" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.718" />
-                        <Parameter id="-sg7u430SE6nGaHxDEFtJg" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.141" />
-                        <Parameter id="Ny-h3YfpEkCuv4P00ABlsA" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-                        <Parameter id="at3aiRA7M0udzecPvTZxzw" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.8" />
-                        <Parameter id="jFcA-n-x-km_Xcv5MB8h1g" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.158" />
-                        <Parameter id="jvEs1suJdkGUO3Mb49Ndmg" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.35" />
-                        <Parameter id="PFUU2noWo02P7Lb1uoVB-Q" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0375" />
-                        <Parameter id="qYq1MFCHXESiJNj72Br0hA" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0483" />
-                        <Parameter id="JPrYLoTD1kexp8J35vN_ng" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0182" />
-                        <Parameter id="RJ2te8tXbkWKQAs3oEk_2A" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0124" />
-                        <Parameter id="cuMI7jga50SU1GmlS7CO9A" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.15" />
-                        <Parameter id="crUXSI5lmECgXCHg6uUV0A" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.282" />
-                        <Parameter id="n1YBAjNlhEe3TI33rVemkA" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.78" />
-                        <Parameter id="yHADKhHwAUCHrBYwQT9o-A" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.456" />
-                        <Parameter id="rCMV6hOPkE6zDcYjbzaNBA" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="2.41" />
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-                        <Container id="Mqff24qDg0q3J5knCoXTZw" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Mucosa" />
-                            <Tag value="SmallIntestineSegment" />
-                            <Tag value="UpperJejunum" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="9pZv2fydg0uyWU8W7m5fAQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="7lSPYpZvaUSQe-Je2rJysw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="AWSLB9BqIUm588s01h4uMw" visible="1" canBeVaried="1" displayUnit="l" />
-                            <MoleculeAmount id="PMNegnlhr0CXVnvfwhXU7g" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                              <Children>
-                                <Parameter id="dLIQebvSBkCo9r_CDmgdAg" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                                <Parameter id="HEQf0j3Il060-DSH3yWK1g" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="QffwbOSrkkiW4JNbgcATVg" visible="0" canBeVaried="0" />
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-                              </Children>
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-                          </Children>
-                        </Container>
-                        <Container id="BiBid5i4Sk2EK94scFpeHw" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Mucosa" />
-                            <Tag value="SmallIntestineSegment" />
-                            <Tag value="UpperJejunum" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="MSdOwPme6km6t-3LjklkEg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="aY5o5qed_kmAOeLAUlsQzw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="bFSKBq9P6ESwCQ7kJZpF0A" visible="1" canBeVaried="1" displayUnit="l" />
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-                              <Children>
-                                <Parameter id="0tAJtmWYp0imL8wF7PTtgg" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                                <Parameter id="T-XvZLzu2U-d-m5p6UdF7A" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="KRWWfL3ct0q8SR3V-8fG7g" visible="0" canBeVaried="0" />
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-                              </Children>
-                            </MoleculeAmount>
-                          </Children>
-                        </Container>
-                        <Container id="MX7UE1AYnEeTRDJ1HM7CBg" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Mucosa" />
-                            <Tag value="SmallIntestineSegment" />
-                            <Tag value="UpperJejunum" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="iLaRY1ogO0eKiDJX84Tmrw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="-ybGu-spkUy6PNHi7dV5AA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="5D8ZOzXK7EGOwj3jJsZ67w" visible="1" canBeVaried="1" displayUnit="l" />
-                            <Parameter id="QeRPWWAshUqjZHw4yQDNOA" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="mmPlMPjMnECVqmG5mkXJMw" visible="1" canBeVaried="1" />
-                            <MoleculeAmount id="OOb7YsEfk02jfdRenZxbbA" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                              <Children>
-                                <Parameter id="11Om9gkVzkSNdyG8ajUyKw" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                                <Parameter id="Iim9CTisdUyf_AcwYaGB8A" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CFYGaPnhW0mmkmVj-xHe8w" visible="0" canBeVaried="0" />
-                                <Observer id="fSSq-TBZmE62I3b-47lmtw" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
-                              </Children>
-                            </MoleculeAmount>
-                          </Children>
-                        </Container>
-                        <Container id="V6G7I9JiAUeouIcb-9qK3g" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="IntestinalSecretionSource" />
-                            <Tag value="Mucosa" />
-                            <Tag value="SmallIntestineSegment" />
-                            <Tag value="UpperJejunum" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="glvmjwTNvUCVxMSOMbem0Q" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="dE28EI6hVk23fUjk1luoMw" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="fIzKnk6CZUq4lx-ZJo_tjQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="m5gWJCaKR0mYkdrFJN9OsQ" visible="1" canBeVaried="1" displayUnit="l" />
-                            <Parameter id="O6ZyXUkTh0KoqrGHAYtyuw" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.3" />
-                            <MoleculeAmount id="zqzRvmsGnUGFDX4cd4aGFQ" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                              <Children>
-                                <Parameter id="8hPbJzaM10OYNJUjTAMewA" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                                <Parameter id="-nCsN_SkzEma-XbogKiQIw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="zIZuOF2sfk6V6fn8-pAeQQ" visible="0" canBeVaried="0" />
-                                <Observer id="xP9hHco6e0mY_DrztL0pGA" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
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-                      <Children>
-                        <Parameter id="FcSCehu420Gq7jYKQfOjFQ" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="uSjt8LuoBUu75Z4-7ZUOCw" visible="0" canBeVaried="1" displayUnit="kg" />
-                        <Parameter id="4Zl-usFhTkiwcDJfZR8CgA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="bqtF4r268EyXGPbRGI3j_Q" visible="1" canBeVaried="1" displayUnit="l" />
-                        <Parameter id="-aOfmleAHk-1PBVPq9IbzA" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="NxoV47Ql00aifPKqk7nOJw" visible="1" canBeVaried="1" displayUnit="l/min" />
-                        <Parameter id="MjMkF1cDLU6ajDcmS6QRcg" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="et1rku1VQkqZCxraRd0LsA" visible="1" canBeVaried="1" displayUnit="l/min" />
-                        <Parameter id="EZ_SSYj70UeU3GWoz5IFUQ" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="iJA8m8URWU2VwP_yDL9F0g" visible="1" canBeVaried="0" displayUnit="l" />
-                        <Parameter id="LyNzZOFHLUGcENaiOvci_w" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="cDO00dCgEUa1Rf_VnhA32g" visible="1" canBeVaried="1" displayUnit="l/min" />
-                        <Parameter id="SuRgVQUiXEimPeCoeqqceA" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="LSHvGCmOBEascdPo-Ab-KQ" visible="1" canBeVaried="1" />
-                        <Parameter id="C0uc0wakmkGm0vpW8Bqkvg" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                        <Parameter id="K01QDC-1I02M5cURc38eqw" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                        <Parameter id="WhaWe09xhEKOuJwG1ySfgg" name="Fraction of regional blood flow rate" description="Regional blood flow fraction supplying the mucosal tissue of the segment" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.219" />
-                        <Parameter id="KTT8HDWzSU-kZrJRNploVg" name="Fraction mucosa" description="Mucosal fraction of regional intestinal tissue mass" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.26" />
-                        <Parameter id="S_g_1ts3QEOKSmHxUhQonA" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="4.5E-08" displayUnit="µm" />
-                        <Parameter id="7jt4l4R-IkOilzx6dn-KgA" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.05" />
-                        <Parameter id="kY1TIpU40ECUiHMk68MKgg" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" visible="1" canBeVaried="1" value="1.53888888888889E-10" displayUnit="ml/min/N" />
-                        <Parameter id="Fkg7xkMuJUqjtQiiXVzbcQ" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="2.5E-07" displayUnit="µm" />
-                        <Parameter id="FhxaXwiLxUelk9Ydl9vQAA" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0487" />
-                        <Parameter id="FGVorR2B_U2ttGh3WNaOLQ" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.06" />
-                        <Parameter id="ypYgIS8k0UmTOQjAbt9Ang" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.13" />
-                        <Parameter id="uzC6Gbtt60aicCgT-sYEWQ" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0163" />
-                        <Parameter id="h8VhYsI6m06AnN7UaIHHSA" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.08" />
-                        <Parameter id="-fzUuj1wPEa4jaFHr3VO_A" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.158" />
-                        <Parameter id="KfUkDJsiL06tLsz0x3Xrrw" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.141" />
-                        <Parameter id="gIUX2Mf4Bkic-A_T0-qMaw" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-                        <Parameter id="i2QyvTBsyU-D-Xjjap2OFQ" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.8" />
-                        <Parameter id="jXw7bc9ky0SYBAXVjKaEIg" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.718" />
-                        <Parameter id="Qjl8k5lYc0Os3RdB-V4PTA" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.32" />
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-                        <Parameter id="8F3J87kdQ0CGQp9NAI5qwg" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0124" />
-                        <Parameter id="phcPkvF3XkyKlKyM_U6mQw" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.282" />
-                        <Parameter id="ILvUiGlLoUSwaBiZqKzW_A" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.15" />
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-                        <Parameter id="eTNSoflQR0mXIG7SIUJqrw" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.78" />
-                        <Parameter id="4x4P-JJuQk-_1MQYM5TBug" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0035" />
-                        <Parameter id="VSX5SCOSXEyPJAb6Pn8tSQ" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="2.41" />
-                        <Container id="qnwzbs7P1EuiOU6I1AbUmw" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="LowerJejunum" />
-                            <Tag value="Mucosa" />
-                            <Tag value="SmallIntestineSegment" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="bwg1-jjTUEmRIIHpuy2wZA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="kA9hRQfvwEeGehL_vWyKUA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="AWSLB9BqIUm588s01h4uMw" visible="1" canBeVaried="1" displayUnit="l" />
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-                                <Parameter id="fxYwuGFa70iZWyscYL2xUA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Llk4QPlyyUKwCA3NV-Fqig" visible="0" canBeVaried="0" />
-                                <Observer id="eMdZWOctjEOtGBj4WYQXAQ" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
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-                        <Container id="kDMQj4cgPkq4YoBI6vj_HA" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="LowerJejunum" />
-                            <Tag value="Mucosa" />
-                            <Tag value="SmallIntestineSegment" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="RaEGjp8bUEiuQWqE3ChP_w" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="qCqBef0L9Ui7tsixNU_zLg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="bFSKBq9P6ESwCQ7kJZpF0A" visible="1" canBeVaried="1" displayUnit="l" />
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-                                <Parameter id="4tB8D5Jrr0qDZE6rplODRA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="5QavN5Cuck-hEPiYzmGVag" visible="0" canBeVaried="0" />
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-                        <Container id="QujFSUBKfUuVAqdGlF3CiA" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="LowerJejunum" />
-                            <Tag value="Mucosa" />
-                            <Tag value="SmallIntestineSegment" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="nTVRotxiAE2862TTR0dhhw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="rbBm2GpWCUKeu-NXNhaYTQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="5D8ZOzXK7EGOwj3jJsZ67w" visible="1" canBeVaried="1" displayUnit="l" />
-                            <Parameter id="iqz0l-VzL0qcrE2sXvfNtQ" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="mmPlMPjMnECVqmG5mkXJMw" visible="1" canBeVaried="1" />
-                            <MoleculeAmount id="84aiMNio202GvttS4U_60A" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
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-                                <Parameter id="Gi6EB0asS060NQWAA8Vx6w" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="p7zZOcLuiE6avIw0GgF-Kg" visible="0" canBeVaried="0" />
-                                <Observer id="fcKRCb7VvUGxhxXU4FQ0SQ" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
-                              </Children>
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-                        <Container id="ZS1XYMqua0eBDvqguAeY6g" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="IntestinalSecretionSource" />
-                            <Tag value="LowerJejunum" />
-                            <Tag value="Mucosa" />
-                            <Tag value="SmallIntestineSegment" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="JZQno6WPD0eFeJoyL7b9yQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="dE28EI6hVk23fUjk1luoMw" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="INGtHoBCYEuX-clsHxPbaw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="m5gWJCaKR0mYkdrFJN9OsQ" visible="1" canBeVaried="1" displayUnit="l" />
-                            <Parameter id="z78u_Iw6QU6UqznIfb8XaQ" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.3" />
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-                                <Parameter id="WUt_eRU_LUOkJSOVNlxdDg" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                                <Parameter id="sMuKWCO6kU2ks8f8t4-EvA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="FlefxO_e3E2iFGIMQcLe0A" visible="0" canBeVaried="0" />
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-                      <Children>
-                        <Parameter id="nkAgVyMIsUCSjyKaNY0YwA" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="uSjt8LuoBUu75Z4-7ZUOCw" visible="0" canBeVaried="1" displayUnit="kg" />
-                        <Parameter id="M18mtnwvIUiQdTYEFB0_pA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="yWKGF2k4XUi8tUSvNhq92Q" visible="1" canBeVaried="1" displayUnit="l" />
-                        <Parameter id="baUnlLkY1k-dGonvxnQNjQ" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="NxoV47Ql00aifPKqk7nOJw" visible="1" canBeVaried="1" displayUnit="l/min" />
-                        <Parameter id="v3wkF0IOHU24n9qJqllYNA" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="et1rku1VQkqZCxraRd0LsA" visible="1" canBeVaried="1" displayUnit="l/min" />
-                        <Parameter id="rTDKYhJQXU2uRpdG62dddA" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="4_Uh7N-65UW8fTmjbmsOPA" visible="1" canBeVaried="0" displayUnit="l" />
-                        <Parameter id="rfn7j5arUEaU1Waomvp5gg" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="cDO00dCgEUa1Rf_VnhA32g" visible="1" canBeVaried="1" displayUnit="l/min" />
-                        <Parameter id="vqccau4QnkKd6usOVX7-aw" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="LSHvGCmOBEascdPo-Ab-KQ" visible="1" canBeVaried="1" />
-                        <Parameter id="2D7EPT3cj0WAf7W697MjEQ" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                        <Parameter id="5qqYeaK6B02Z7HDpvKSWYg" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                        <Parameter id="z7l8OUvVRUisqzHG7lX0eQ" name="Fraction mucosa" description="Mucosal fraction of regional intestinal tissue mass" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.13" />
-                        <Parameter id="M-z0Yo5150KsuwMEc6ZlZA" name="Fraction of regional blood flow rate" description="Regional blood flow fraction supplying the mucosal tissue of the segment" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.2345" />
-                        <Parameter id="FfVC9m5rqky28hHQ_S9-ww" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="2.5E-07" displayUnit="µm" />
-                        <Parameter id="9UHLkmmOm0S84ObA7qt8SQ" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" visible="1" canBeVaried="1" value="1.53888888888889E-10" displayUnit="ml/min/N" />
-                        <Parameter id="2p-OMgpUsk2ZxR0RJxhSFw" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.05" />
-                        <Parameter id="BVLP5Z-tC0qGcVzIZUMjTw" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="4.5E-08" displayUnit="µm" />
-                        <Parameter id="PWrA6RLHWUyc07Tf-dBsfw" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.06" />
-                        <Parameter id="7NQQJDH8BEaUWFf7o56gHg" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0487" />
-                        <Parameter id="595Hm29RDECAiC53Spry4A" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.13" />
-                        <Parameter id="3cJWUf7jPUeRERfZtiKNRQ" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.08" />
-                        <Parameter id="2ZVp7pF0rkO_MbJunYtGpA" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0163" />
-                        <Parameter id="sxJFERj4W0iYleBHvjVrCg" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.8" />
-                        <Parameter id="Sq_WT3lL9kumptVFjk0CeA" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.158" />
-                        <Parameter id="OrJf314V6EyNp4441UdoQw" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.141" />
-                        <Parameter id="FSC5FZqGpUqxCVvU1SQaaw" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-                        <Parameter id="p0p03vuyoEeZcowgRm6mGQ" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.718" />
-                        <Parameter id="Yl9DnuplEE2O8L4aZ4VRKA" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.31" />
-                        <Parameter id="g0hU5jg6mkW8NKHg20Ddsg" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0483" />
-                        <Parameter id="V2Zkmk_YRESGV_bYO_Jeww" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0375" />
-                        <Parameter id="fP-1uJ-CrUKdy0TVAnIYtg" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0124" />
-                        <Parameter id="jyp6jNPdqEagPQokk2lTMA" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0182" />
-                        <Parameter id="eyW6dw6J0k6KLMtsvN6-Pw" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.282" />
-                        <Parameter id="Z9ZE8G1sZ0KS-OZCJ5HGSw" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.15" />
-                        <Parameter id="wbMt8QzlTkiNnUMgD1DZjw" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.78" />
-                        <Parameter id="y018doGg40iq2VUqCWLmyA" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.456" />
-                        <Parameter id="hLUKdJdoNk-xyKHognbgRw" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0035" />
-                        <Parameter id="MDFv0D2Ga0uoTV67ZtN45Q" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="2.41" />
-                        <Container id="wiKdxf5lkUaXODbbzJ_MgA" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Mucosa" />
-                            <Tag value="SmallIntestineSegment" />
-                            <Tag value="UpperIleum" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="7mCV0eypi0S5ql3lQLmcaA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="OwynRWIMIkS2jZMUMX65ow" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="AWSLB9BqIUm588s01h4uMw" visible="1" canBeVaried="1" displayUnit="l" />
-                            <MoleculeAmount id="OH4tJOZD_USLmfI7ahxt3w" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                              <Children>
-                                <Parameter id="ek4WCEc6v0yuzxuhwnBBLQ" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                                <Parameter id="2k4e7jPJZkubhZrj68088w" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="WlOg-KUZREW2kU3ietRnlQ" visible="0" canBeVaried="0" />
-                                <Observer id="bTrYKIyHjUeLiR6tLw_X0g" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
-                              </Children>
-                            </MoleculeAmount>
-                          </Children>
-                        </Container>
-                        <Container id="PSVoSQGqZEqHtyvSo86Uug" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Mucosa" />
-                            <Tag value="SmallIntestineSegment" />
-                            <Tag value="UpperIleum" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="HI6IFHB8E0Wdxvnt_d20IQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="8Xns6YLi20u4iHlMN80EGQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="bFSKBq9P6ESwCQ7kJZpF0A" visible="1" canBeVaried="1" displayUnit="l" />
-                            <MoleculeAmount id="AmS23HbI_0aVgZpvEhgrww" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                              <Children>
-                                <Parameter id="I3FvuKh400KDyTVf9_yyTg" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                                <Parameter id="TV8S5oW060al1vPe-y8w7w" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="VOEd7LQgokykILce_YRefQ" visible="0" canBeVaried="0" />
-                                <Observer id="Z0ctV3kILkykZXdqpFi29g" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
-                              </Children>
-                            </MoleculeAmount>
-                          </Children>
-                        </Container>
-                        <Container id="mL_v9Y4FbUCAI1t4VRNB6g" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Mucosa" />
-                            <Tag value="SmallIntestineSegment" />
-                            <Tag value="UpperIleum" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="155gw5ARVEC9_pEvZvMSbw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="PytdbaiZU0-48jusL-pLxQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="5D8ZOzXK7EGOwj3jJsZ67w" visible="1" canBeVaried="1" displayUnit="l" />
-                            <Parameter id="9MktmCGmq0ezHfCcwuLqig" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="mmPlMPjMnECVqmG5mkXJMw" visible="1" canBeVaried="1" />
-                            <MoleculeAmount id="hrj09OGQBE2Gcy30ntzRWA" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                              <Children>
-                                <Parameter id="_E2x8ZB59E-XBkTjZF975A" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                                <Parameter id="eVZhYTgNu06kB5YhmL-IJg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Xzi_1qWplkq8DZexTbsA2w" visible="0" canBeVaried="0" />
-                                <Observer id="JcrbSx4pr0eWm9XILuKqHw" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
-                              </Children>
-                            </MoleculeAmount>
-                          </Children>
-                        </Container>
-                        <Container id="Mn_3bNMJfUilEEDCF8BgJg" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="IntestinalSecretionSource" />
-                            <Tag value="Mucosa" />
-                            <Tag value="SmallIntestineSegment" />
-                            <Tag value="UpperIleum" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="Xs2TjAIaC0ylwLoMFWuCJA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="dE28EI6hVk23fUjk1luoMw" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="SyRWsTuZRUGftAIdBcx1Ng" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="m5gWJCaKR0mYkdrFJN9OsQ" visible="1" canBeVaried="1" displayUnit="l" />
-                            <Parameter id="f6LxQxrXZU6F5jS0GL8SlA" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.3" />
-                            <MoleculeAmount id="27w6YBfNQkyh-7D9Mivddg" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                              <Children>
-                                <Parameter id="8tZhCW4t4EKOxWnokgEaJQ" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                                <Parameter id="l5b7hynXBkGbcZEnEaYPuA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="5oh8RmywUUKfE_PYhuYHaQ" visible="0" canBeVaried="0" />
-                                <Observer id="GrQM3HWG80qoqwRhpF3c1Q" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
-                              </Children>
-                            </MoleculeAmount>
-                          </Children>
-                        </Container>
-                      </Children>
-                    </Container>
-                    <Container id="A5EY2dtuQ0S8dsnX4o_ZBw" name="LowerIleum" description="Lower Ileum" icon="LowerIleum" mode="Logical" containerType="Compartment">
-                      <Children>
-                        <Parameter id="pRaE-fqj7EaWUq1bUijMUg" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="uSjt8LuoBUu75Z4-7ZUOCw" visible="0" canBeVaried="1" displayUnit="kg" />
-                        <Parameter id="uxsyk0q-uUSIZgiV95fDuw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="48pb79Tg_U2mIwfCNKEWrQ" visible="1" canBeVaried="1" displayUnit="l" />
-                        <Parameter id="DgN36nSdRECkDw2GaI_Yvg" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="PpDtkQj1SkWhFoXwJa9W1w" visible="1" canBeVaried="0" displayUnit="l" />
-                        <Parameter id="slScpueehU-49-Faxub2kA" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="et1rku1VQkqZCxraRd0LsA" visible="1" canBeVaried="1" displayUnit="l/min" />
-                        <Parameter id="s_OW-E3HTEWBJXNASXTKLg" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="NxoV47Ql00aifPKqk7nOJw" visible="1" canBeVaried="1" displayUnit="l/min" />
-                        <Parameter id="UQ8B5duYX0WGAKNQ0OAArA" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="cDO00dCgEUa1Rf_VnhA32g" visible="1" canBeVaried="1" displayUnit="l/min" />
-                        <Parameter id="Uy5YNxgepEuh3bEH96ipFw" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="LSHvGCmOBEascdPo-Ab-KQ" visible="1" canBeVaried="1" />
-                        <Parameter id="qO5YW2KdZEeTvma7TDw7ag" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                        <Parameter id="Mh2iKPmUxk2uph-M_capjw" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                        <Parameter id="v_RGIJnNj0GCRAxE9fqXcQ" name="Fraction mucosa" description="Mucosal fraction of regional intestinal tissue mass" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.13" />
-                        <Parameter id="cvYJX-HYkESo-8Al_9rQ0Q" name="Fraction of regional blood flow rate" description="Regional blood flow fraction supplying the mucosal tissue of the segment" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.2345" />
-                        <Parameter id="hxZOBOm3yUKrrjQwjWWP3w" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.05" />
-                        <Parameter id="lp6OSm-LXUi_Mgc_uQ65lg" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="4.5E-08" displayUnit="µm" />
-                        <Parameter id="nEDogpTmhkiQYkoADJWH_w" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" visible="1" canBeVaried="1" value="1.53888888888889E-10" displayUnit="ml/min/N" />
-                        <Parameter id="2sbmJz3Fr0mJqX36vn2qAw" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="2.5E-07" displayUnit="µm" />
-                        <Parameter id="Zdhfk1g88UCp1SktFfl24g" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0487" />
-                        <Parameter id="cApgcyLWGk-8JtQ8jTlCWg" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.06" />
-                        <Parameter id="j61L6PTak0OzC3Ey7WHN4Q" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.13" />
-                        <Parameter id="sTVH2yOEakeJjzxJbJswrA" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0163" />
-                        <Parameter id="1m682-B9ZEWrVvHsJIBbsw" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.08" />
-                        <Parameter id="RLFTy-BP6EOssm4HF8x8yw" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.158" />
-                        <Parameter id="so9sk59y9kmTJj3QyYz7JQ" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.141" />
-                        <Parameter id="Edngv139pk2-OvkbmgsZYA" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-                        <Parameter id="rMi8u_DsF0a5KS5H9GvR_Q" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.718" />
-                        <Parameter id="aAShIyFfkUimOO86oFBbUA" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.8" />
-                        <Parameter id="zzzz6hIAd023plfAQmMbRA" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.32" />
-                        <Parameter id="icpLLQjiREyftl8Vsp_Rww" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0483" />
-                        <Parameter id="IPmbpkclwUejj4HKVa7wvA" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0375" />
-                        <Parameter id="bjQMuK4H40-SXVj3DpKjYQ" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0124" />
-                        <Parameter id="KWzujO57mkGK9tez-MepsA" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0182" />
-                        <Parameter id="fh9cBtVAP0-U0RXuTbnmsA" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.15" />
-                        <Parameter id="2jEjimbut0OUxDbEzgrW5g" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.282" />
-                        <Parameter id="jlVMMWYWzEO-Z-bJmPvoEg" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.456" />
-                        <Parameter id="-MGJ6tqntUSMoDIU3ihNgA" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.78" />
-                        <Parameter id="fx5DFXNvQEOIDxAeVByIxw" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0035" />
-                        <Parameter id="K97yL1hQZ0iujRnrMoSsaA" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="2.41" />
-                        <Container id="rrdHQQGA002quyiJj14SNw" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="LowerIleum" />
-                            <Tag value="Mucosa" />
-                            <Tag value="SmallIntestineSegment" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="EtTYjkCQJEOn0gocCOc0qQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="5T9P-wz7YE6eubvouXCiWQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="AWSLB9BqIUm588s01h4uMw" visible="1" canBeVaried="1" displayUnit="l" />
-                            <MoleculeAmount id="0cutZov5eEiqqp_uiBzdtw" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                              <Children>
-                                <Parameter id="wN72NHgmD0un-PVUECVp-Q" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                                <Parameter id="dtuy9_eSrk2oETfkotgnew" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IP_3Ta4i-EO1lQ8xR1RW2g" visible="0" canBeVaried="0" />
-                                <Observer id="M_A5Lqly80CYNOSHhT9QWw" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
-                              </Children>
-                            </MoleculeAmount>
-                          </Children>
-                        </Container>
-                        <Container id="NNtCjKsDKEmpfBZtoykFkw" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="LowerIleum" />
-                            <Tag value="Mucosa" />
-                            <Tag value="SmallIntestineSegment" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="jrwZLZ441EeO8kzLOZiZ_A" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="CarNZfZBJkuErb9nitIbJg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="bFSKBq9P6ESwCQ7kJZpF0A" visible="1" canBeVaried="1" displayUnit="l" />
-                            <MoleculeAmount id="o1HQX8-RRUmWuRf1rvmfuA" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                              <Children>
-                                <Parameter id="zbCTiXqmHU6qo3fjE6r8VQ" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                                <Parameter id="34G8bkW0rU68q-vtBVXpig" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="fjnww3ESJUq1tV2PgUACIA" visible="0" canBeVaried="0" />
-                                <Observer id="nDrpcHH3o0CcOfRAm-nA1Q" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
-                              </Children>
-                            </MoleculeAmount>
-                          </Children>
-                        </Container>
-                        <Container id="uqiskikve0-qI31H7jOgWg" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="LowerIleum" />
-                            <Tag value="Mucosa" />
-                            <Tag value="SmallIntestineSegment" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="l2gAhcuo2EmtoyZQ5dQuPQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="2hoiMvy5UUyZDa6uxcZbMQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="5D8ZOzXK7EGOwj3jJsZ67w" visible="1" canBeVaried="1" displayUnit="l" />
-                            <Parameter id="73Zmf_ZEIkyutXB2jI4XVw" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="mmPlMPjMnECVqmG5mkXJMw" visible="1" canBeVaried="1" />
-                            <MoleculeAmount id="RRkRhMuE70C8xM04dgNTkw" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                              <Children>
-                                <Parameter id="PqK68-i4WU2arnJYsbDLrw" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                                <Parameter id="aF9vLUzc202iJlBeDkd9bg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="dIewFJV8rkebXxIcP9r2mw" visible="0" canBeVaried="0" />
-                                <Observer id="penbVSlVuUW9rEMtsVHiiw" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
-                              </Children>
-                            </MoleculeAmount>
-                          </Children>
-                        </Container>
-                        <Container id="sI2lB80kS0qpJ8_ruusBLA" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="IntestinalSecretionSource" />
-                            <Tag value="LowerIleum" />
-                            <Tag value="Mucosa" />
-                            <Tag value="SmallIntestineSegment" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="mZ14VGKlFk-bCNtGnre06Q" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="dE28EI6hVk23fUjk1luoMw" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="1yrTgkgAUEiBDYGLQ1xtMA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="m5gWJCaKR0mYkdrFJN9OsQ" visible="1" canBeVaried="1" displayUnit="l" />
-                            <Parameter id="MN__K8Sd9kG7UexF5O2dqw" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.3" />
-                            <MoleculeAmount id="2dcifeUtpkujhqGqlE3Qnw" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                              <Children>
-                                <Parameter id="DI67SpONC0uremPELE_OhA" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                                <Parameter id="IYoz7-UTSkaRQXW7jDKi8Q" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Lw5BgQyUiEGMocKoIKUFbg" visible="0" canBeVaried="0" />
-                                <Observer id="gnYk_gW07kq7yrxk7i2Ohg" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
-                              </Children>
-                            </MoleculeAmount>
-                          </Children>
-                        </Container>
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="A_wINMWnN0W8pazdejYTFg" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Observer id="Jdw70gQ9rUCh133N9hhjZg" name="Interstitial Unbound" description="Interstitial Unbound" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="ZyvJ8fAke0mbYrfSrxcACw" displayUnit="µmol/l" />
-                    <Observer id="l7vmcUI27kKYij90tmnJ3A" name="Intracellular Unbound" description="Intracellular Unbound" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="lHCXjnyQt0Wf_kfsvc1dyw" displayUnit="µmol/l" />
-                    <Observer id="huJvi_gS60SC51EFoMjcPw" name="Total Tissue (Small Intestine)" description="Mucosa and nonmucosa tissue" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="56ALDO1PPEaWXwRwJCty7Q" displayUnit="µmol/l" />
-                  </Children>
-                </Container>
-              </Children>
-            </Container>
-            <Container id="po_gtzNnlUusCPTspKCZOA" name="LargeIntestine" description="LargeIntestine" icon="LargeIntestine" mode="Logical" containerType="Organ">
-              <Tags>
-                <Tag value="Portal Vein Supplying Organ" />
-                <Tag value="TissueOrgan" />
-              </Tags>
-              <Children>
-                <Parameter id="KJ5QF88zAEe2Yr_Mp0hTTA" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="uSjt8LuoBUu75Z4-7ZUOCw" visible="0" canBeVaried="1" displayUnit="kg" />
-                <Parameter id="7w8cJG-FSESe2crE7AjWUw" name="Volume (mucosa)" description="Volume of mucosa" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="gMkJPynOskSVvu68YhL01A" visible="1" canBeVaried="1" displayUnit="l" />
-                <Parameter id="EpM0eUkQCE-TrctPt9B9Kw" name="Large intestinal transit time factor" description="Large intestinal transit time factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="F485a5dR20-QtTuqFrMsaw" visible="0" canBeVaried="1" />
-                <Parameter id="RC1cGQOd2U-emwNJH4hGxA" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="P-n1FKFwZk-Z6_CIrtgKiw" visible="1" canBeVaried="0" displayUnit="l/min" />
-                <Parameter id="1Nf4MYN7u0WG-Mu3kv9MfA" name="Fluid recirculation flow rate (incl. mucosa)" description="Fluid recirculation flow rate between plasma and interstitial space (incl. mucosa)" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="mJJHlRTSNkmnisAFp0vU0g" visible="1" canBeVaried="1" displayUnit="l/min" />
-                <Parameter id="5qGo1D4E_kisfgPVIP4MbQ" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="o-c90HQfc0Gbn3yuK2d4KA" visible="1" canBeVaried="0" displayUnit="l/min" />
-                <Parameter id="YFSI7dgfhk6NhWLaDo01dg" name="Lymph flow rate (incl. mucosa)" description="Lymph flow rate (incl. mucosa)" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="Yz3UrPPwck-1Ng_Y6QeNCg" visible="1" canBeVaried="1" displayUnit="l/min" />
-                <Parameter id="1ypem1ZwfE-tHzAkT9d1xA" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="iGPeHxTV80WINhMPGzT1gQ" visible="1" canBeVaried="0" displayUnit="l" />
-                <Parameter id="hq7oAtmEsEa7rKVSVWKhiw" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="LSHvGCmOBEascdPo-Ab-KQ" visible="1" canBeVaried="1" />
-                <Parameter id="7mfq-KqvPU29gc_9wV67VA" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="jdhhCNoMYE-s118HG9XzZw" visible="1" canBeVaried="1" displayUnit="l/min" />
-                <Parameter id="U-HkRWyXJkCRDKPZzK0afw" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                <Parameter id="_kKmkgsd-0e6s2K7cqt54A" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.75" />
-                <Parameter id="A5xyGtA2JUCEkWKSEpfYDQ" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                <Parameter id="mDi0mc-NIUmJ7e6sfXF4IA" name="Mucosa blood flow fraction" description="Blood fraction which goes to mucosa" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.75" />
-                <Parameter id="YHBUslOlWEClr5YTPxV2dw" name="Large intestinal transit time factor slope" description="Large intestinal transit time factor slope" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" visible="0" canBeVaried="0" value="0.938" displayUnit="1/min" />
-                <Parameter id="VCNJawsPCUqOLL8wolSHgw" name="Large intestinal transit time factor intercept" description="Large intestinal transit time factor intercept" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="0" value="47.6" />
-                <Parameter id="vmb2St8LSkW3RQnGrUVm1Q" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="4.5E-08" displayUnit="µm" />
-                <Parameter id="vUp-R1Buq0WdxjGVpjdXWA" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="2.5E-07" displayUnit="µm" />
-                <Parameter id="BHneLhAK90W1TzP-jge4Hw" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.05" />
-                <Parameter id="z7GeacEJtU2aToicpfqeAQ" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" visible="1" canBeVaried="1" value="1.86944444444444E-10" displayUnit="ml/min/N" />
-                <Parameter id="p5erebVP5k-cnfYcMzhWzQ" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.062" />
-                <Parameter id="Umd-tyV4pEagvkSMuFi-Ig" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0487" />
-                <Parameter id="xlSQ9fk5QECSI0Tnii_myw" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.024" />
-                <Parameter id="VCXiFc1diEOW6CC1C0v7Ug" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.133" />
-                <Parameter id="sWWGm28bDky2X1upG92Vrg" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0163" />
-                <Parameter id="0_omnZXT1kOCOd1Fq8XWlQ" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.141" />
-                <Parameter id="CgKr-qFZZk2IEcTsqb-nEA" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.718" />
-                <Parameter id="ZpHozClTy0CQODyeEgsTCw" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.792" />
-                <Parameter id="-Op-H-j3N0-pqVtmDqRznA" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.158" />
-                <Parameter id="ItHxzFykxEuJEduVL8XZ0w" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-                <Parameter id="e8UvFApvika_3VrI5ZaUUg" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.094" />
-                <Parameter id="5lDR6f79JE6yyecMAJx-og" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0483" />
-                <Parameter id="0fY1kp53pEOvuz8W6XfoYw" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0375" />
-                <Parameter id="v49Swu4rKESA3P4x28FJ_Q" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0182" />
-                <Parameter id="4sBj9Icatku3AMKzZKSRig" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0124" />
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-                <Parameter id="zb6TZolYhEuyxLnxxwgkKw" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.456" />
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-                <Parameter id="tENHr93wp0mVn3L2a1AVeg" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="2.41" />
-                <Parameter id="KRprie7bBk-4f9jwYQp7WA" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0035" />
-                <DistributedParameter id="2_gW9d8VZ0ywO_d26OV5Lg" name="Large intestinal transit time" description="The time required for the passage of a non-absorbable compound through the large intestine, defined as the time span between small intestinal transit (i.e. the point at which 90% of the drug mass has entered the caecum) and the time at which 70% is excreted into feces" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" formula="2HUhd-FIGUC6noInuklctQ" mode="Logical" visible="1" displayUnit="h">
-                  <Children>
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-                    <Parameter id="-Wr5Tu-VakKbTrIngc-Fvw" name="Mean" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" visible="0" canBeVaried="1" value="2652" displayUnit="h" />
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-                    <Parameter id="ea0GkOvAZ0GoEOULT0dkhg" name="Mean" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" visible="0" canBeVaried="1" value="0.6305" displayUnit="ml/min/100g organ" />
-                    <Parameter id="vBm1SrkXi0mgw_z_iTHUVw" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" visible="0" canBeVaried="1" value="0.031525" displayUnit="ml/min/100g organ" />
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-                  <Tags>
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-                    <Tag value="Portal Vein Supplying Organ" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="zln7PPZdSUKB7xs6IFAyhw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="l9NO7fMdYUOxGylLVw7_lA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="2znHM-7hCESyDJPFkFbbsw" visible="1" canBeVaried="1" displayUnit="l" />
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-                        <Parameter id="t2lW2EPri065K58qeLah-w" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="upCvbO3rb0iMk20bR10Siw" visible="0" canBeVaried="0" />
-                        <Observer id="t_OWWUz2e0S5QfxzhDbs5g" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
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-                <Container id="SXH64aI-W0uPsXU5nSDPlA" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="LargeIntestine" />
-                    <Tag value="Portal Vein Supplying Organ" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="_rXQVE_a3Umj9-_vZzR5tg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="f3nC9WUl102v5NR_Of8G3w" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="iiR-BhU-e0i9WlcPjQsNdg" visible="1" canBeVaried="1" displayUnit="l" />
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-                      <Children>
-                        <Parameter id="Y7hhm-gcJ0q07ezRW3Ns2A" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                        <Parameter id="d1OTGOlrWEuilBUHDUElhw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="aHEqPSvPGEGjT0bcYQY8GQ" visible="0" canBeVaried="0" />
-                        <Observer id="oYoofiUxrUu6ap1exYicTQ" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
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-                <Container id="3CzsBUOdUEOwjbwyWnTvGw" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="LargeIntestine" />
-                    <Tag value="Portal Vein Supplying Organ" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="iWpO7_FWt0SkJ3i9_qe5SA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="qSuUHGZZqU6VwQ_JDa_tIw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="8PysAt2r-Uuae7YiFGiTNQ" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Parameter id="z8m011nKGES3xUH0jzPBJw" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="mmPlMPjMnECVqmG5mkXJMw" visible="1" canBeVaried="1" />
-                    <MoleculeAmount id="ogyOwK65X0uL1DkZot3EUA" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                      <Children>
-                        <Parameter id="u1qpQpsYxUurDCnFKv415Q" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                        <Parameter id="g2IFaqY24ku5vGbhS0a8TA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="uCXhdhN0ckiQRwRoTYBcVQ" visible="0" canBeVaried="0" />
-                        <Observer id="9b7tS4tb-0S0z80GZvIVMQ" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
-                      </Children>
-                    </MoleculeAmount>
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-                  <Tags>
-                    <Tag value="LargeIntestine" />
-                    <Tag value="Portal Vein Supplying Organ" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="-m52w6hmDEGLIEgpmXw17w" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="YcDySoEECUCkabMfcgVuzw" visible="0" canBeVaried="0" displayUnit="l" />
-                    <Parameter id="JxZanPxAikmKij4sqCPCoQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="Ue-GxIfM90qPHZMmN2fUlw" visible="1" canBeVaried="1" displayUnit="l" />
-                    <Parameter id="iJCEtNGzWEy1rdY-aXZYlA" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.4" />
-                    <MoleculeAmount id="-Vdyhy1qAEGZJkWudpNPKA" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                      <Children>
-                        <Parameter id="4WBtFndYHE22fnESds_lgg" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                        <Parameter id="WxaNfeyvVUWsp9jybCm0-w" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="A_IOro_WwEu1O72l6SplmA" visible="0" canBeVaried="0" />
-                        <Observer id="LF7dgOurt0KKhfWKnObKkQ" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
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-                  <Children>
-                    <Container id="hznOOD5ynUKXeXntSXnYrQ" name="Caecum" description="Cecum" icon="Caecum" mode="Logical" containerType="Compartment">
-                      <Children>
-                        <Parameter id="aZ0NZFvD1k2IaAxIX2a9Bg" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="uSjt8LuoBUu75Z4-7ZUOCw" visible="0" canBeVaried="1" displayUnit="kg" />
-                        <Parameter id="Nu9ZL0VRUEiKwYGp_ghkgg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="v5wmJnBiz0mTtk-ar-SUKw" visible="1" canBeVaried="1" displayUnit="l" />
-                        <Parameter id="eSwf5gouDUKKjtsjZQv56A" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="lLfXRJbfUkGeKcY-iG1hzQ" visible="1" canBeVaried="0" displayUnit="l" />
-                        <Parameter id="KOunUE0kg0mSlIsZI99Zig" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="NxoV47Ql00aifPKqk7nOJw" visible="1" canBeVaried="1" displayUnit="l/min" />
-                        <Parameter id="bO16AA0M1ES6kJ00P-HJCw" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="et1rku1VQkqZCxraRd0LsA" visible="1" canBeVaried="1" displayUnit="l/min" />
-                        <Parameter id="2pnwkl1hHUaFO7EJZ-cUPg" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="cDO00dCgEUa1Rf_VnhA32g" visible="1" canBeVaried="1" displayUnit="l/min" />
-                        <Parameter id="GOV-2O79CUuq2TreVgyl-w" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="LSHvGCmOBEascdPo-Ab-KQ" visible="1" canBeVaried="1" />
-                        <Parameter id="KVKt9TkOQ02o-5h0lOEybg" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                        <Parameter id="Mw8kJ05DuUuwfktvP35mkQ" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                        <Parameter id="Bc5wsBSEO0a_-3nGrep66A" name="Fraction of regional blood flow rate" description="Regional blood flow fraction supplying the mucosal tissue of the segment" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.084706" />
-                        <Parameter id="OTdxqtqFhUe8rVI3h8tJ9Q" name="Fraction mucosa" description="Mucosal fraction of regional intestinal tissue mass" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.19" />
-                        <Parameter id="HG-n4Kiy9ECavG6NWh68jQ" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="4.5E-08" displayUnit="µm" />
-                        <Parameter id="2AiLbHTkbku4tUMj9I3r6w" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.05" />
-                        <Parameter id="a6tBvx-XLE--Mh_JH4n8AA" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="2.5E-07" displayUnit="µm" />
-                        <Parameter id="4iTjAQFyCUaGyJVEk02krg" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" visible="1" canBeVaried="1" value="1.86944444444444E-10" displayUnit="ml/min/N" />
-                        <Parameter id="DnczRCBQjUyOva4xMzhe7g" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0487" />
-                        <Parameter id="v17BHzlzlEGhTCLiFF6WXA" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.06" />
-                        <Parameter id="3QgVAfTWxkCvKW1AIzgCtw" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.13" />
-                        <Parameter id="NLeAD0g7fUSDvqA--nm_5A" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.08" />
-                        <Parameter id="-Ot8aO3k30eTlj0nkC2Qtw" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0163" />
-                        <Parameter id="wkCeHunQ40SLaYni0YfPtA" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.718" />
-                        <Parameter id="XoeqKfUvF0COLOseSxn2-g" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.141" />
-                        <Parameter id="Pj6cKyyZt02GVRaf0gy3Ig" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.8" />
-                        <Parameter id="bVyxSQaAHEug9zVibLwgKw" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.158" />
-                        <Parameter id="YlFicvJOPU-uninqIdbmrQ" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-                        <Parameter id="CAoMfbg2lUuiYaTbTB2GNg" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.73" />
-                        <Parameter id="hWGbH8QIDUO0crbVtCqmpA" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0483" />
-                        <Parameter id="usYPbtEMt0Czgz8ZmisvMw" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0375" />
-                        <Parameter id="8zNVnt81tkOEp32C_MiJwg" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0124" />
-                        <Parameter id="hmLsF86eEkevVLT-p7Ntgg" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0182" />
-                        <Parameter id="ktzONXAtMU6A7a6_xwWy-A" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.282" />
-                        <Parameter id="SMpok1ovl0eWQTuiNjWTfw" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.15" />
-                        <Parameter id="cWJAhjAbtke-EJIU1mY3yw" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.456" />
-                        <Parameter id="AjsZle9_t0y9xBllxHuovw" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.78" />
-                        <Parameter id="ayLV1MAMM0usJnsyGaDHdg" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0035" />
-                        <Parameter id="iBazNAwIOkaCF5WbIHGz_g" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="2.41" />
-                        <Container id="qk0qF8uZI06cnoMMMXTreA" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Caecum" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="lAWPvAKldEyN9MBBTkpfMg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="oo5_XCmusEmO-vQW04mT2w" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="AWSLB9BqIUm588s01h4uMw" visible="1" canBeVaried="1" displayUnit="l" />
-                            <MoleculeAmount id="Lpte9WeV50K2AalO8MrxAw" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                              <Children>
-                                <Parameter id="5AwX1H6TC0maWvlD_hcYvQ" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                                <Parameter id="1cVzMgMcA0qnbiaVQs7ZWg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="xlQsWe6fu0KgXTipRA2F5Q" visible="0" canBeVaried="0" />
-                                <Observer id="pGd1sItJnUaX5y0aDHB_bw" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
-                              </Children>
-                            </MoleculeAmount>
-                          </Children>
-                        </Container>
-                        <Container id="6kGZy_3g3U-NktadHdhW3Q" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Caecum" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="aEbAcsGXukqmSayW8AYClA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="IBuAvwKQd0yqKTUpkNsbgQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="bFSKBq9P6ESwCQ7kJZpF0A" visible="1" canBeVaried="1" displayUnit="l" />
-                            <MoleculeAmount id="05yORl8O3EeGbBTdKhAhHA" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                              <Children>
-                                <Parameter id="0FmvhckWmUippjyxRi0aCg" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                                <Parameter id="umtR6uj9NEi_Ir6paNWVgg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="W6FdArXtR0eSm3wKoZGYfA" visible="0" canBeVaried="0" />
-                                <Observer id="PTpBR5iMOk6xQxDpKJvQ2g" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
-                              </Children>
-                            </MoleculeAmount>
-                          </Children>
-                        </Container>
-                        <Container id="3hhWlW8CU02dQMHm8E1PTg" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Caecum" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="QUyRKS7AmU26Hq5Kz2nAKw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="PEBwXgx9_k-BZ_7_rcW1vg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="5D8ZOzXK7EGOwj3jJsZ67w" visible="1" canBeVaried="1" displayUnit="l" />
-                            <Parameter id="Wx53-EuqP0CIhQDjqQ0mXQ" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="mmPlMPjMnECVqmG5mkXJMw" visible="1" canBeVaried="1" />
-                            <MoleculeAmount id="CNB35o9wBEK0VIuxxircsA" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                              <Children>
-                                <Parameter id="loWQ-9nEQ0OvSmBc4EBCfw" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                                <Parameter id="VSVBUguZck-r22IZj77ltg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="whqdmHrWs0yRUbkr-1qkrg" visible="0" canBeVaried="0" />
-                                <Observer id="TAG0PxlmiUKxgkrj3vmllA" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
-                              </Children>
-                            </MoleculeAmount>
-                          </Children>
-                        </Container>
-                        <Container id="t-B68_pEAUyLs_Kjh2XotQ" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Caecum" />
-                            <Tag value="IntestinalSecretionSource" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="vpLsvSm-h06lVO2WhvjTjQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="dE28EI6hVk23fUjk1luoMw" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="DwOXxCI74Uu2j53YVPkyiA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="m5gWJCaKR0mYkdrFJN9OsQ" visible="1" canBeVaried="1" displayUnit="l" />
-                            <Parameter id="HTShN6IUYEqAL9wmFlnnSA" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.3" />
-                            <MoleculeAmount id="gaxUc91cjECJ7Oyx20_0iw" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                              <Children>
-                                <Parameter id="-9NtwEo1ZkmHdgdxeTIJoA" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                                <Parameter id="MUIP2PoUi0qYvaTZ4lSeqg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Dw-eIrIp1kq-_Cuz8PZjPw" visible="0" canBeVaried="0" />
-                                <Observer id="mAlpyQT_VUKeM3PXvnpsMA" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
-                              </Children>
-                            </MoleculeAmount>
-                          </Children>
-                        </Container>
-                      </Children>
-                    </Container>
-                    <Container id="jtzoNNW17EezzLh8Xeawsw" name="ColonAscendens" description="Colon Ascendens" icon="ColonAscendens" mode="Logical" containerType="Compartment">
-                      <Children>
-                        <Parameter id="Y2PQfq-Mck-Ie3xCfs7tNA" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="uSjt8LuoBUu75Z4-7ZUOCw" visible="0" canBeVaried="1" displayUnit="kg" />
-                        <Parameter id="PWr_f9XeS0uH45-1spwwFA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="sHDXa0deUUOJ9tdxgBtmQA" visible="1" canBeVaried="1" displayUnit="l" />
-                        <Parameter id="lAM_Mw9oBkGMWeCZ2aEZSw" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="qp9GXwt6rkOqY42IUZXfzA" visible="1" canBeVaried="0" displayUnit="l" />
-                        <Parameter id="0wrNVFYvdk6wJkKei1Re8A" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="NxoV47Ql00aifPKqk7nOJw" visible="1" canBeVaried="1" displayUnit="l/min" />
-                        <Parameter id="DyzAsI-8ckaWyTi0CbTZ1g" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="et1rku1VQkqZCxraRd0LsA" visible="1" canBeVaried="1" displayUnit="l/min" />
-                        <Parameter id="IXmWIBeOmU-GWiZ8QqyH_g" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="cDO00dCgEUa1Rf_VnhA32g" visible="1" canBeVaried="1" displayUnit="l/min" />
-                        <Parameter id="CFrGjf2OoEGDa7P8ruEBbw" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="LSHvGCmOBEascdPo-Ab-KQ" visible="1" canBeVaried="1" />
-                        <Parameter id="3kAeZtmfnUCz-bU2KIqXFg" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                        <Parameter id="CwE547flbkahr_1MUZspvw" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                        <Parameter id="02iq__qJGUKb28UncN3_Dw" name="Fraction mucosa" description="Mucosal fraction of regional intestinal tissue mass" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.19" />
-                        <Parameter id="MlqY7ebkZk2S0UCsLnPNlQ" name="Fraction of regional blood flow rate" description="Regional blood flow fraction supplying the mucosal tissue of the segment" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.15529" />
-                        <Parameter id="Rbzhsvdqxkq8KyY8uxg-_w" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="4.5E-08" displayUnit="µm" />
-                        <Parameter id="Eem945_6-kWIzmL7nMMyVg" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="2.5E-07" displayUnit="µm" />
-                        <Parameter id="6mlWbQhFr0C9iwE0OljbhA" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" visible="1" canBeVaried="1" value="1.86944444444444E-10" displayUnit="ml/min/N" />
-                        <Parameter id="pVgX4Q2W10m11Wdv_2N_Hg" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.05" />
-                        <Parameter id="aTEPIbXUgEe4QnJAZCPS9w" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.06" />
-                        <Parameter id="F-Cw9LjUxUSJ_1QjK_XPSA" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0487" />
-                        <Parameter id="_ngP5p1y2ESzwX9oExTFIQ" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.13" />
-                        <Parameter id="ZUyqgC3560au7M6w75umCQ" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.08" />
-                        <Parameter id="Ue6JVjFtxEK81Gm6-ALc7A" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0163" />
-                        <Parameter id="l3vjuHn5UkyM-yZ70dgyQg" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.141" />
-                        <Parameter id="aJDm-V_Yak-GqksaSg9cWA" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.158" />
-                        <Parameter id="At7GrBrx1k-AYK8NfqwKQQ" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-                        <Parameter id="JON-wlHVgEygaZsMp9Qplw" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.718" />
-                        <Parameter id="UzeVxtsqqUmKiuHVEq4jaA" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.8" />
-                        <Parameter id="UmasU7CkgU6D9dFV2xVHjw" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.73" />
-                        <Parameter id="dkGdMXUViEyivQ2sbsuM8g" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0483" />
-                        <Parameter id="kmQXgTbvXkmyEAMaWjS-iw" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0375" />
-                        <Parameter id="qZ7GdJ1X1kCy6N7KSn0Qqw" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0182" />
-                        <Parameter id="ZzIWX8Gl1US7D7qBTwZVkA" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0124" />
-                        <Parameter id="eAr3TX97iEqWN981-gbcGg" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.15" />
-                        <Parameter id="J87uv3v2zkW9ZAO1FDaFKg" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.282" />
-                        <Parameter id="LFKPxFGujEq0fhTpfNz2cA" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.456" />
-                        <Parameter id="ZQEBHRFSV067aTSsqqb8yA" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.78" />
-                        <Parameter id="sMejWd-0G0eDT3t4VZo_3w" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="2.41" />
-                        <Parameter id="gxb2F_fvU0yIbGVrLAHkOg" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0035" />
-                        <Container id="Aivr7qttHUatCWB0Vus_ew" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="ColonAscendens" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="hmsOd5GfEkaY8GuaDj_HjA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="K0jDEg31eUaHaHDDmYAujA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="AWSLB9BqIUm588s01h4uMw" visible="1" canBeVaried="1" displayUnit="l" />
-                            <MoleculeAmount id="0zNjwXhGpkSaSYQZC4yzdw" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                              <Children>
-                                <Parameter id="MYF25tGLsEO19u5Jz69Hmg" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                                <Parameter id="l8wnQmeoHUq3LyUBACIqfA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="4xTw7NGSPkS9Qn1bH3Tu8A" visible="0" canBeVaried="0" />
-                                <Observer id="2pPu7riJyU66dbhQbxc1pw" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
-                              </Children>
-                            </MoleculeAmount>
-                          </Children>
-                        </Container>
-                        <Container id="-BbZRBaQ_EGB3LiH3qZ_Ag" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="ColonAscendens" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="3VkQg_UKq0OT7GlzqL5LnQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="ihf3BnE_7EWS8I-L5Sc6rA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="bFSKBq9P6ESwCQ7kJZpF0A" visible="1" canBeVaried="1" displayUnit="l" />
-                            <MoleculeAmount id="Ls0R4hvRKki76eHKnnDq6g" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                              <Children>
-                                <Parameter id="hy3RaV0C702NVhLwLHqJGA" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                                <Parameter id="_ilQhGrKWUS49jA8QxSefw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="z6upADJwc0-M6_1osjwBcg" visible="0" canBeVaried="0" />
-                                <Observer id="J75iXrv5kUqwz1zssihTkQ" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
-                              </Children>
-                            </MoleculeAmount>
-                          </Children>
-                        </Container>
-                        <Container id="uvlcQsL-GUCowlN-t4ha-g" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="ColonAscendens" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="FdfyL2ghK0CFRi_RKhe3aQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="0jJcPDvdGUubOZr_5PooZQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="5D8ZOzXK7EGOwj3jJsZ67w" visible="1" canBeVaried="1" displayUnit="l" />
-                            <Parameter id="ubYgAocxC0aljhI2GGUgRg" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="mmPlMPjMnECVqmG5mkXJMw" visible="1" canBeVaried="1" />
-                            <MoleculeAmount id="9bgCoeKsLkKvhkx6FdY3iQ" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
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-                                <Parameter id="dXuQQi-SHEyn95svSF8Rcg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="ZPS0lhWToUyPQPJp0cXdaw" visible="0" canBeVaried="0" />
-                                <Observer id="AzgKY6yBIkOjPX7Sx0PTmg" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
-                              </Children>
-                            </MoleculeAmount>
-                          </Children>
-                        </Container>
-                        <Container id="Qny8z-gEIUO-cU6ir0RqzA" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="ColonAscendens" />
-                            <Tag value="IntestinalSecretionSource" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="22PUkkcJoEKE2nShsatK3Q" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="dE28EI6hVk23fUjk1luoMw" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="L3sjhrAiW06kF_qjS-u_GA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="m5gWJCaKR0mYkdrFJN9OsQ" visible="1" canBeVaried="1" displayUnit="l" />
-                            <Parameter id="DuXz6DsvLEG3aS7kPZ3m2Q" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.3" />
-                            <MoleculeAmount id="Y5D_k9113E2RRgqowuESsw" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                              <Children>
-                                <Parameter id="AZC-mFqa_kqiCkV3rY8S2w" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                                <Parameter id="t9BHWbWWq0KpjoEhMoML0g" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="WbrS8thoh0C-lVTVOQjX2Q" visible="0" canBeVaried="0" />
-                                <Observer id="4g9XJaWqoUefK3F_LncBwg" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
-                              </Children>
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-                      </Children>
-                    </Container>
-                    <Container id="Eo03n39MwUmvQDHUregcXQ" name="ColonTransversum" description="Colon Transversum" icon="ColonTransversum" mode="Logical" containerType="Compartment">
-                      <Children>
-                        <Parameter id="HShkSfe5uU6uzXi6L9p12w" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="uSjt8LuoBUu75Z4-7ZUOCw" visible="0" canBeVaried="1" displayUnit="kg" />
-                        <Parameter id="gb_0r5gMeU23-w8rYriudQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="Tfb9WXnJCkawvENV_l-g7w" visible="1" canBeVaried="1" displayUnit="l" />
-                        <Parameter id="Ms-uyeAysEmDB1iGZaAPAg" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="IMi1JmNuqUWjsGtRtUwn1A" visible="1" canBeVaried="0" displayUnit="l" />
-                        <Parameter id="1C5To3t8E0W5YMSWCHxVCA" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="et1rku1VQkqZCxraRd0LsA" visible="1" canBeVaried="1" displayUnit="l/min" />
-                        <Parameter id="HdXL_QbPjU-YxgKX6lO-kw" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="NxoV47Ql00aifPKqk7nOJw" visible="1" canBeVaried="1" displayUnit="l/min" />
-                        <Parameter id="ur074lkhuEyVE4EKaQUZAQ" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="cDO00dCgEUa1Rf_VnhA32g" visible="1" canBeVaried="1" displayUnit="l/min" />
-                        <Parameter id="4zvrbsjyeEuRmh8tbBSdFQ" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="LSHvGCmOBEascdPo-Ab-KQ" visible="1" canBeVaried="1" />
-                        <Parameter id="nfvVZxxdtEufPseiFEw5Fw" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                        <Parameter id="k2Vxhwt2TUiXQdvQkWcDcQ" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                        <Parameter id="OQ7JBuGASkeSfKOAhTyrAw" name="Fraction of regional blood flow rate" description="Regional blood flow fraction supplying the mucosal tissue of the segment" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.32" />
-                        <Parameter id="Buutm5YyA0y4AjZVz6Qaww" name="Fraction mucosa" description="Mucosal fraction of regional intestinal tissue mass" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.21" />
-                        <Parameter id="j6nItkJtykmOZAi-faN6Ow" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="4.5E-08" displayUnit="µm" />
-                        <Parameter id="etFybMFPeEWVI2foCbTExA" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="2.5E-07" displayUnit="µm" />
-                        <Parameter id="LTPpVsFG90G2PbdK9LJ5Lg" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" visible="1" canBeVaried="1" value="1.86944444444444E-10" displayUnit="ml/min/N" />
-                        <Parameter id="xRd4WrsvhEyI-2Ti6vDZuQ" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.05" />
-                        <Parameter id="nfFh4ZifekWINKDHPJTY1g" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.06" />
-                        <Parameter id="vDhK_5LylUeaFXsvMBekQg" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0487" />
-                        <Parameter id="EFr1IQddnEWQ7Xvr99XPnA" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.12" />
-                        <Parameter id="Ms9vPJzsVk-oYVowo3yIMQ" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0163" />
-                        <Parameter id="sU6IC24I30aUcHDgaEBY-Q" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.08" />
-                        <Parameter id="ezFEpVuBQk2UfVyvXe_8Rw" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.158" />
-                        <Parameter id="ZTWWOO1fp0yPoRNw1pZZ8Q" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.718" />
-                        <Parameter id="EDNq6G8_ck-b4FOSIyYgrQ" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.8" />
-                        <Parameter id="WwMZXJX21kmOvlyXL2dyAA" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-                        <Parameter id="ERfE0E8YCku5myHxrjIbzw" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.141" />
-                        <Parameter id="_LmIPgw3Vki3RViqJvEbkQ" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.74" />
-                        <Parameter id="EKCFhg85R0CzcIw-880Hqg" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0483" />
-                        <Parameter id="QX-UkvM9eUyXxsMSSpIsUA" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0375" />
-                        <Parameter id="GnstFS_bq0Gi4KF-r_G1LQ" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0182" />
-                        <Parameter id="UxUMKPoB5ES4hSIe1wJKmg" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0124" />
-                        <Parameter id="KAdooIb00kaMUSjR053eLQ" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.282" />
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-                        <Parameter id="P_cEnDxwe0WMWhe-IxfmLA" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.456" />
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-                        <Parameter id="Az_mJy2y10CABrBzet9d0A" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="2.41" />
-                        <Parameter id="Z6_PRtXZyEK4v5007UGV1Q" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0035" />
-                        <Container id="-P41WVvf4kGpY92ttsK8NQ" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="ColonTransversum" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="10AjYARjBkWdMaxWrCMT5A" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="ncjwmn32DEOtRf2nutfFVA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="AWSLB9BqIUm588s01h4uMw" visible="1" canBeVaried="1" displayUnit="l" />
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-                                <Parameter id="gLyLksMbRUq4RcZUfFDD0g" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                                <Parameter id="arv7LHAmnUOsdxBVADvaBA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="TmOLUta4_0i8J71StV6Rig" visible="0" canBeVaried="0" />
-                                <Observer id="IdYVCErWfEyn0DDRgniomw" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
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-                            </MoleculeAmount>
-                          </Children>
-                        </Container>
-                        <Container id="nK4V9tiRUUy-zjLhRo56OA" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="ColonTransversum" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="g2iHtbkYpU2wJWy2QOyPow" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="G-JN6euf2Uun6lP1i4xmpQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="bFSKBq9P6ESwCQ7kJZpF0A" visible="1" canBeVaried="1" displayUnit="l" />
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-                              <Children>
-                                <Parameter id="braonP_1nketBQS3dkIOYw" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                                <Parameter id="p5slByzv4USVlEzPz3UbxA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="TmQYn1D9BUyYxyJhBzeuvg" visible="0" canBeVaried="0" />
-                                <Observer id="lJj0T3nuo0C1ZxHOQVbG8g" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
-                              </Children>
-                            </MoleculeAmount>
-                          </Children>
-                        </Container>
-                        <Container id="uSnfTCjzEEKsrn-SJCCw0g" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="ColonTransversum" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="nKYrREfQm0yzmw6snl3Nxg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="e8-nHEefBkiPriJNM6UNRw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="5D8ZOzXK7EGOwj3jJsZ67w" visible="1" canBeVaried="1" displayUnit="l" />
-                            <Parameter id="2P_4AvOtSEWVgq-il8kSnQ" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="mmPlMPjMnECVqmG5mkXJMw" visible="1" canBeVaried="1" />
-                            <MoleculeAmount id="8b6AM8coN0GCBiF054tGIw" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
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-                                <Parameter id="UnSJL5j3eEuu4kID3WHZSg" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                                <Parameter id="ocR4Ah6u3kGcY-cg3O5ojQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="QNdB6CbDZ0aPPpQntIjShQ" visible="0" canBeVaried="0" />
-                                <Observer id="Q61oMzzzwEKXSW2ElntYYA" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
-                              </Children>
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-                          </Children>
-                        </Container>
-                        <Container id="bQfRvdb_CEakRfpxkmjp1g" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="ColonTransversum" />
-                            <Tag value="IntestinalSecretionSource" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="l6A1dp-fnUy3SNEaB80rSQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="dE28EI6hVk23fUjk1luoMw" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="dZVyQqzxKUuqHoxeGVCqxA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="m5gWJCaKR0mYkdrFJN9OsQ" visible="1" canBeVaried="1" displayUnit="l" />
-                            <Parameter id="e5YnD4tY-0CRq6NXmfZzTg" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.3" />
-                            <MoleculeAmount id="H0qyxGwyUkWmeHAlvjEj4w" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                              <Children>
-                                <Parameter id="oQONFFJ07EWD8yN__-FU1A" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                                <Parameter id="17v7eeaFWkeq5wiMbieSzQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="mOY_O9ElgEa82lAqEptlJw" visible="0" canBeVaried="0" />
-                                <Observer id="P0-6oMraME2GC-pnJQenzA" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
-                              </Children>
-                            </MoleculeAmount>
-                          </Children>
-                        </Container>
-                      </Children>
-                    </Container>
-                    <Container id="Eyd-qA3B-Uibv5cS2nnbzQ" name="ColonDescendens" description="Colon Descendens / Distal Colon 1" icon="ColonDescendens" mode="Logical" containerType="Compartment">
-                      <Children>
-                        <Parameter id="oMhX48ArOk-RiJgOBV5eoQ" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="uSjt8LuoBUu75Z4-7ZUOCw" visible="0" canBeVaried="1" displayUnit="kg" />
-                        <Parameter id="dF5muo4BZUCsjl4SfyeARg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="3HlR5bC0I0ip9T2uJKueHQ" visible="1" canBeVaried="1" displayUnit="l" />
-                        <Parameter id="xgJApB0pYEmD2ysKQYJpcg" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="NxoV47Ql00aifPKqk7nOJw" visible="1" canBeVaried="1" displayUnit="l/min" />
-                        <Parameter id="HqiZMHyv3U2WSPP15tF_JA" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="et1rku1VQkqZCxraRd0LsA" visible="1" canBeVaried="1" displayUnit="l/min" />
-                        <Parameter id="ylRG6W_81Um9bI3czJiiUw" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="uaQ4VG7LJ0-FzyI6A0Kr9Q" visible="1" canBeVaried="0" displayUnit="l" />
-                        <Parameter id="3uuZcmB5iEiadr_a7irTGA" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="cDO00dCgEUa1Rf_VnhA32g" visible="1" canBeVaried="1" displayUnit="l/min" />
-                        <Parameter id="IZcI5q8nWkaqDsx-TgxhXg" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="LSHvGCmOBEascdPo-Ab-KQ" visible="1" canBeVaried="1" />
-                        <Parameter id="6Gb46hXvxkunrG3uy-Fswg" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                        <Parameter id="ydEcL4hE5keG51LcmwyCTg" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                        <Parameter id="RT22-6m-KEK1se5VOO9IXA" name="Fraction mucosa" description="Mucosal fraction of regional intestinal tissue mass" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.14" />
-                        <Parameter id="3RbsY-jqKU-4SL-EGjKhtQ" name="Fraction of regional blood flow rate" description="Regional blood flow fraction supplying the mucosal tissue of the segment" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.24" />
-                        <Parameter id="xLWr83m4R0O5uEe7yTDumw" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="4.5E-08" displayUnit="µm" />
-                        <Parameter id="D1bVnz8GekyYTiI-cAkPKg" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="2.5E-07" displayUnit="µm" />
-                        <Parameter id="LHrviWfm0UOUrlbXSXtr5Q" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" visible="1" canBeVaried="1" value="1.86944444444444E-10" displayUnit="ml/min/N" />
-                        <Parameter id="qE4jx49axUSlQVpMf-hRIA" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.05" />
-                        <Parameter id="tdAM33zCEE-5y5Lo6CBuhQ" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0487" />
-                        <Parameter id="8cikcBdz-0iUJUaa3adXiw" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.06" />
-                        <Parameter id="aYEtCTrMx0uOFdpCfamQWg" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.12" />
-                        <Parameter id="W2JYrvrs9E2Mh9zOuLABTQ" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.08" />
-                        <Parameter id="5nKRRiblq0O0FQA9_NtQOw" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0163" />
-                        <Parameter id="EwpUFYRkPEqyNW9w0S20oA" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.158" />
-                        <Parameter id="AdM5zlSFekeTpsr6fir4-w" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-                        <Parameter id="M7K9shuNaUWjLl-n74jr3Q" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.141" />
-                        <Parameter id="IqKBqPFRyEOx-GlADQiY1w" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.8" />
-                        <Parameter id="4AV-p5cNb0KTJi38bf7TGQ" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.718" />
-                        <Parameter id="xb8rrQYVV0uFKNArBDOKmQ" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.74" />
-                        <Parameter id="KYRmpZU8H0yrQNEOPcxQRQ" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0375" />
-                        <Parameter id="zOb1EhoSSkyvFePc5xnTxw" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0483" />
-                        <Parameter id="-sJW98pcsky59WFKEmGOrg" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0182" />
-                        <Parameter id="IxrZTUkGJUe9FzBOFw_-WQ" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0124" />
-                        <Parameter id="H6OvFBJUCE2UN3k9tjmUAg" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.15" />
-                        <Parameter id="9UBg6kqcnUiGKm8Rf3b-NA" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.282" />
-                        <Parameter id="BJaIybmMA0igJ8_JHhLyTQ" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.78" />
-                        <Parameter id="wv8dDY8PwUGjmWTJs5IGQw" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.456" />
-                        <Parameter id="ESKw249cBU2THiSd8dPqhw" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0035" />
-                        <Parameter id="jHymTXgNXUWtfyyVK9Tv6A" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="2.41" />
-                        <Container id="IYSOBD2MW0SByEccir1gtg" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="ColonDescendens" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="Y8c_LbS3xU-kbT79cDcgSw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="9jc4ZJ5nE0GM3HExiabjFQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="AWSLB9BqIUm588s01h4uMw" visible="1" canBeVaried="1" displayUnit="l" />
-                            <MoleculeAmount id="fRScY5akTkSbcR1hbKcs5Q" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                              <Children>
-                                <Parameter id="HAjpLApo9kG8O3TP53Lt6g" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                                <Parameter id="GqdxWGQlXEy8gSBrVJQqSg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="r_rg-1cyFEqdW6fn1578NA" visible="0" canBeVaried="0" />
-                                <Observer id="6AXee4V_Q0SjGdh2YgPYfg" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
-                              </Children>
-                            </MoleculeAmount>
-                          </Children>
-                        </Container>
-                        <Container id="0Ysv4senlEeNmmozTIAQkw" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="ColonDescendens" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="74femimPT0SD6NkUeFxSow" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="rWBFdG5X_0mA0vlTBNiQow" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="bFSKBq9P6ESwCQ7kJZpF0A" visible="1" canBeVaried="1" displayUnit="l" />
-                            <MoleculeAmount id="3eMVtSbfykKuZmsiS31jUg" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                              <Children>
-                                <Parameter id="DoTrykpCCEuQT-zn5LETDg" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                                <Parameter id="Zgnn9mIvvkG4BTIdn6S5PQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="2OMBj4D3u06KMsuP9Ggi8w" visible="0" canBeVaried="0" />
-                                <Observer id="kH-LrToJj0yv_afGX__Gag" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
-                              </Children>
-                            </MoleculeAmount>
-                          </Children>
-                        </Container>
-                        <Container id="YUV1KDlDvUS4N8X86jTR_w" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="ColonDescendens" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="BgEEIghq4USl7-BN95XfEQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="LB1FVxIN80OeQLJqvZnB_Q" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="5D8ZOzXK7EGOwj3jJsZ67w" visible="1" canBeVaried="1" displayUnit="l" />
-                            <Parameter id="znmOoQBHdEmplc7L2LGDPw" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="mmPlMPjMnECVqmG5mkXJMw" visible="1" canBeVaried="1" />
-                            <MoleculeAmount id="OTfVa-Dmd029ivqi8nkVCQ" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                              <Children>
-                                <Parameter id="V5SO7AcXfkq0Hrb-Rs9riQ" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                                <Parameter id="6LQKxx26U02hhrY5ux7KqA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="I5t2Ze3F-ECWlQKKQbdq5A" visible="0" canBeVaried="0" />
-                                <Observer id="zwQZmmZJYEygJQF8QnKktA" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
-                              </Children>
-                            </MoleculeAmount>
-                          </Children>
-                        </Container>
-                        <Container id="yvx9mFVur0KdwvcmwHHcQw" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="ColonDescendens" />
-                            <Tag value="IntestinalSecretionSource" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="Ync0tUPUWESLFITHgm8T7w" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="dE28EI6hVk23fUjk1luoMw" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="w29kvM78a0KTOqDzvJKtQw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="m5gWJCaKR0mYkdrFJN9OsQ" visible="1" canBeVaried="1" displayUnit="l" />
-                            <Parameter id="XyNAVXhpXU6nSs9cd1SB2g" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.3" />
-                            <MoleculeAmount id="XdsPQQqfnU68je9V8z203Q" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                              <Children>
-                                <Parameter id="PWGh8dGva0iLDfEg2K2FGw" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                                <Parameter id="Y9eZ9u3qK0mK40GnAi7TPQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="VJgVVdT0c0Woc8nztDksNA" visible="0" canBeVaried="0" />
-                                <Observer id="fHLh5Enm4U6Jbl9ssvW4Hw" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
-                              </Children>
-                            </MoleculeAmount>
-                          </Children>
-                        </Container>
-                      </Children>
-                    </Container>
-                    <Container id="We1fNhXFXk-g3c6l8NQf4w" name="ColonSigmoid" description="Colon Sigmoid / Distal Colon 2" icon="ColonSigmoid" mode="Logical" containerType="Compartment">
-                      <Children>
-                        <Parameter id="YnAhYso41Uaz2X8k-tNarQ" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="uSjt8LuoBUu75Z4-7ZUOCw" visible="0" canBeVaried="1" displayUnit="kg" />
-                        <Parameter id="42qB8xCXTkekpBAh-3Kwtg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="HdOxCAdxo0WbGvz4CigSwA" visible="1" canBeVaried="1" displayUnit="l" />
-                        <Parameter id="A1NN2XgKrU210C5Ho5tTdQ" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="NxoV47Ql00aifPKqk7nOJw" visible="1" canBeVaried="1" displayUnit="l/min" />
-                        <Parameter id="uHKN-b_QhUqOFIUA7LdKlw" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="et1rku1VQkqZCxraRd0LsA" visible="1" canBeVaried="1" displayUnit="l/min" />
-                        <Parameter id="amOV9R1vck6owViCqOA7Yg" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="d-TaC6E_QEO9RvMa9SWwHQ" visible="1" canBeVaried="0" displayUnit="l" />
-                        <Parameter id="LvwN2-ZsR06gVd_6JWSnlw" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="cDO00dCgEUa1Rf_VnhA32g" visible="1" canBeVaried="1" displayUnit="l/min" />
-                        <Parameter id="LR864pK-wUmrVTtdrJWp8w" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="LSHvGCmOBEascdPo-Ab-KQ" visible="1" canBeVaried="1" />
-                        <Parameter id="Fg-Avj5w7Ua5y_c1z9RsEA" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                        <Parameter id="ZAxnXZhkV0-D59cUrFkwFQ" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                        <Parameter id="VULFgHmP3ki041GqBwqL2g" name="Fraction of regional blood flow rate" description="Regional blood flow fraction supplying the mucosal tissue of the segment" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.135" />
-                        <Parameter id="N6-MLaBEPUG8MSED3iN8lA" name="Fraction mucosa" description="Mucosal fraction of regional intestinal tissue mass" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.3" />
-                        <Parameter id="CKt1pynpa0CjF9jltu4d_g" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="4.5E-08" displayUnit="µm" />
-                        <Parameter id="xE5nMkLvvkuxh-3FXMutWQ" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="2.5E-07" displayUnit="µm" />
-                        <Parameter id="EPqIYHXq30-p3zzL6R6TzA" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.05" />
-                        <Parameter id="O4SYnyBNvUaoFNILS2HhWg" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" visible="1" canBeVaried="1" value="1.86944444444444E-10" displayUnit="ml/min/N" />
-                        <Parameter id="_maCu93HKkKxnBEBdgGgbQ" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0487" />
-                        <Parameter id="GRFfjdVY0U-yqhlKl330Gw" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.06" />
-                        <Parameter id="OwwYyAs7Y0-0CdZpEVF0fQ" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.08" />
-                        <Parameter id="4WKt4pYtY0GUAhYRrCJS8Q" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0163" />
-                        <Parameter id="uvJJoJNuuECVav0i23QP9g" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.08" />
-                        <Parameter id="K2KnTcNgJECojbl6gO2fZQ" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.8" />
-                        <Parameter id="BaZNUzp5UEKcQhbLcPOEZQ" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.141" />
-                        <Parameter id="ILyit_uqHUKdPGMKU7u5ww" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.158" />
-                        <Parameter id="vXW8fxcDkUuWKNyZlCxGPg" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-                        <Parameter id="K8XKRD7EsEqkPG0ZGtXDwg" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.718" />
-                        <Parameter id="HcNmw3n9L0GxA-ee74vLWA" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.78" />
-                        <Parameter id="3yJHX1YqUkmWkmO0kY5ZPA" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0483" />
-                        <Parameter id="lqyNfw7IYkeRUeVqwELEAw" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0375" />
-                        <Parameter id="jFtMxQWQwEWTyXUh71Dzpg" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0124" />
-                        <Parameter id="N32ozzInakGyFZmjxxYvcw" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0182" />
-                        <Parameter id="a6T_UZUceEuBVmoYQm0fxg" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.15" />
-                        <Parameter id="lvVd-s3TuU2LQh8sr_FBQg" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.282" />
-                        <Parameter id="DFcEAxQBr02zbcP4REyCig" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.78" />
-                        <Parameter id="90gkAjcm_kaZt_iysl0yZg" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.456" />
-                        <Parameter id="d4V4mjWpiUKlNfAfcKn9KA" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="2.41" />
-                        <Parameter id="qyFSL_Z7oEya_oWv9b3Vng" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0035" />
-                        <Container id="bzYLFyk2JkmtP6F5xOz6QQ" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="ColonSigmoid" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="mBp2PZ3oBk6c7luzMCpF6g" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="cegg3V6oSEejO_V01i7b9Q" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="AWSLB9BqIUm588s01h4uMw" visible="1" canBeVaried="1" displayUnit="l" />
-                            <MoleculeAmount id="xTGJR_rEKE6vG1pK_dnKhA" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                              <Children>
-                                <Parameter id="H-8tY_B9ykaueSRVT1iu9A" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                                <Parameter id="vjSQR8_MqUiYOe5hPFDhvQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="sfbJhewAsEavS48Fioa7Kg" visible="0" canBeVaried="0" />
-                                <Observer id="VmVB_K0S7kix4q98FPSftg" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
-                              </Children>
-                            </MoleculeAmount>
-                          </Children>
-                        </Container>
-                        <Container id="96RIWxzJSUmdHw6J1qxOyw" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="ColonSigmoid" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="368p-3J9M0O_2GeZSti99A" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="S3xCZ1otKUqM04FojSd6PQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="bFSKBq9P6ESwCQ7kJZpF0A" visible="1" canBeVaried="1" displayUnit="l" />
-                            <MoleculeAmount id="nPc7HZ7onEeWVXA5yaAQVg" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                              <Children>
-                                <Parameter id="T3J5p9TNqkCCaWxAjqveLg" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                                <Parameter id="XbR3wG83PU2bCcCpIvakHA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="PBgH45rwxUy4jRl2YGMd8g" visible="0" canBeVaried="0" />
-                                <Observer id="uWEddUWZ0Uy31qUi3CfC1Q" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
-                              </Children>
-                            </MoleculeAmount>
-                          </Children>
-                        </Container>
-                        <Container id="5HpeQ-ekKkOS2la6bazFiA" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="ColonSigmoid" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="ua4JjIjcHkeM73BSQk46Wg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="JtdOUNgHzUuJx9Nq1cOJGw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="5D8ZOzXK7EGOwj3jJsZ67w" visible="1" canBeVaried="1" displayUnit="l" />
-                            <Parameter id="jmp-aIjQiU-YOGYxZ4Sufw" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="mmPlMPjMnECVqmG5mkXJMw" visible="1" canBeVaried="1" />
-                            <MoleculeAmount id="EoUr17TiR061xnfZLxGy_A" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                              <Children>
-                                <Parameter id="IVgD5nbUakKu8n9x7FLdFQ" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                                <Parameter id="X2Zk5i1KLkakHfVDsYPsdw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="r0MwnWLJ1kuV_BTmDJhU3A" visible="0" canBeVaried="0" />
-                                <Observer id="scf8b85HYUGSqmOsQ4QyMw" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
-                              </Children>
-                            </MoleculeAmount>
-                          </Children>
-                        </Container>
-                        <Container id="dEAYEXl0dk2Rv-tt0gU9NA" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="ColonSigmoid" />
-                            <Tag value="IntestinalSecretionSource" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="pNQs3kgyQEqY641RvEn59Q" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="dE28EI6hVk23fUjk1luoMw" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="2u3An4R1vEGXqeUHYZab2g" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="m5gWJCaKR0mYkdrFJN9OsQ" visible="1" canBeVaried="1" displayUnit="l" />
-                            <Parameter id="sYah6r3t7UuwgVMzB6nHRg" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.3" />
-                            <MoleculeAmount id="_FYwdcJVXUmHAbB3mDuZPw" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                              <Children>
-                                <Parameter id="RhVa77MVsUuBgruXkwk94Q" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                                <Parameter id="TxwzzKB2SEKbF7A9E3_vxA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="i-svm7btNki1MmZSx7aPCQ" visible="0" canBeVaried="0" />
-                                <Observer id="nmDsQeq_pk6jwvoM1q61pg" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
-                              </Children>
-                            </MoleculeAmount>
-                          </Children>
-                        </Container>
-                      </Children>
-                    </Container>
-                    <Container id="eTVDE_oMIU2FA7eBEzy5rA" name="Rectum" description="Rectum" icon="Rectum" mode="Logical" containerType="Compartment">
-                      <Children>
-                        <Parameter id="XShI2O5E80WZzizmlSWgyw" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="uSjt8LuoBUu75Z4-7ZUOCw" visible="0" canBeVaried="1" displayUnit="kg" />
-                        <Parameter id="B3USVGiGB0KW7nibk2-GXQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="XYOKHZZUBkuhmruMPUCfwQ" visible="1" canBeVaried="1" displayUnit="l" />
-                        <Parameter id="sUN--K0BEk-hJpvvlLV8hg" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="et1rku1VQkqZCxraRd0LsA" visible="1" canBeVaried="1" displayUnit="l/min" />
-                        <Parameter id="N_L453vK-kqqSEYg7ID4CQ" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="uAObWhqnuUWsf3Ha6Zakyw" visible="1" canBeVaried="0" displayUnit="l" />
-                        <Parameter id="R0lS2QH0c0aWkPQzdzG8ig" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="NxoV47Ql00aifPKqk7nOJw" visible="1" canBeVaried="1" displayUnit="l/min" />
-                        <Parameter id="OPDqbUgWX0ebP4dOOQznCg" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="cDO00dCgEUa1Rf_VnhA32g" visible="1" canBeVaried="1" displayUnit="l/min" />
-                        <Parameter id="vguyG-M0nkWk6XI89ow0dA" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="LSHvGCmOBEascdPo-Ab-KQ" visible="1" canBeVaried="1" />
-                        <Parameter id="xZ-A7gK-FUKkTseRw9O9ag" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                        <Parameter id="JnRxdj5Tbkq4HZ25Fu-Wjw" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                        <Parameter id="zvqvTwnRNUKLQJbv3AXyJA" name="Fraction of regional blood flow rate" description="Regional blood flow fraction supplying the mucosal tissue of the segment" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.055" />
-                        <Parameter id="sceLS3xZIUu5ktsso4Bj3A" name="Fraction mucosa" description="Mucosal fraction of regional intestinal tissue mass" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.3" />
-                        <Parameter id="afJAtJk5TkKkWV8EX5EfJg" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="4.5E-08" displayUnit="µm" />
-                        <Parameter id="YjzJjH77P0KOFgUJmKLaFA" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.05" />
-                        <Parameter id="zMhy5Y-9oE6_4g4z3sN0tQ" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" visible="1" canBeVaried="1" value="1.86944444444444E-10" displayUnit="ml/min/N" />
-                        <Parameter id="CxLSEMW7VE2VNaSEWIV_mQ" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="2.5E-07" displayUnit="µm" />
-                        <Parameter id="Wv_UVX7xnU2hcIEToZRNyQ" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.06" />
-                        <Parameter id="KDibI6QkG0iCFznPAMuFxg" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0487" />
-                        <Parameter id="8pkgVWRTm0qnaO0OopejIQ" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.08" />
-                        <Parameter id="sjycTN2IKE2w_qyuO8hP6A" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.08" />
-                        <Parameter id="Qaf-DiEop0uDCfW05z4dFg" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0163" />
-                        <Parameter id="MCDdk8jRck6oFn1gNCVfLw" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.718" />
-                        <Parameter id="EIv1yIgkNkmRnZYl9V_agQ" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.8" />
-                        <Parameter id="td0J_8Byb02nIgTEiEQEyQ" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.158" />
-                        <Parameter id="sM-1i1yGFEeXc5HwnFm_gw" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-                        <Parameter id="bEuZwoxg40KO47fPHL3qeQ" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.141" />
-                        <Parameter id="cjRuStDOh0-eW3PMrTE8lg" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.69" />
-                        <Parameter id="6wsInkEwAkW74s29GZt8nA" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0483" />
-                        <Parameter id="cM45tElAZ06dC1IIs_mHnA" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0375" />
-                        <Parameter id="gatsTldYwEu2hQuIYEupzA" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0182" />
-                        <Parameter id="EmLf0OMyfUOU_AJRgmr1Ig" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0124" />
-                        <Parameter id="BllRYb5xkUurqYD8AFtyzw" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.282" />
-                        <Parameter id="jnZ_1V1BSUShwbxv8MyMGw" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.15" />
-                        <Parameter id="9jbvQoZdGk-lCiwqrP__Ig" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.456" />
-                        <Parameter id="Y51Wj2bYn0iscEGNSMSQ1w" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.78" />
-                        <Parameter id="BiAsJ5R23E-WXND0SDAVWQ" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0035" />
-                        <Parameter id="milO74DoIEe_5Ny1SKJvfg" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="2.41" />
-                        <Container id="WMIBikKwrEe1vMFMiv-ong" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                            <Tag value="Rectum" />
-                          </Tags>
-                          <Children>
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-                            <Parameter id="RAf2cNoro02VA1h3kXKm_g" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="AWSLB9BqIUm588s01h4uMw" visible="1" canBeVaried="1" displayUnit="l" />
-                            <MoleculeAmount id="w16XRTEu1kCkEKI9PKRZEg" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                              <Children>
-                                <Parameter id="pPhh-Rz6W0Wnp7eT-judUg" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                                <Parameter id="xCKVc5ZORku-Jttb3gteXA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="XUfzHl2FQ0yNUxOuYS5ubA" visible="0" canBeVaried="0" />
-                                <Observer id="qgirPOhzF0iPtlfARw0xYw" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
-                              </Children>
-                            </MoleculeAmount>
-                          </Children>
-                        </Container>
-                        <Container id="XuC4VFLrok2cYGGvu6Zk6A" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                            <Tag value="Rectum" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="hOuJfTQsW0iPwShj249F_g" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="zQ8VhEpfw0-tfL0h_gQnEw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="bFSKBq9P6ESwCQ7kJZpF0A" visible="1" canBeVaried="1" displayUnit="l" />
-                            <MoleculeAmount id="r0gwYEI_O0mcxiowmhPpKQ" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                              <Children>
-                                <Parameter id="nXB1jHcvSk-70kISkg2Dog" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                                <Parameter id="Zo2MkO1g-EmynnVdDQFiLw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="XYWLxGquMkON44W_eEYKiQ" visible="0" canBeVaried="0" />
-                                <Observer id="yFz_NyBc30qoQWsMYYNrSQ" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
-                              </Children>
-                            </MoleculeAmount>
-                          </Children>
-                        </Container>
-                        <Container id="k2lXslAcv0O9A3Owj-loLg" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                            <Tag value="Rectum" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="gwYDerA-s0WvcrAFjSAX4g" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="B_T8h5ZoIE2oNzQ37A98Fw" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="RFSgjGLtw022h8N3pka71g" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="5D8ZOzXK7EGOwj3jJsZ67w" visible="1" canBeVaried="1" displayUnit="l" />
-                            <Parameter id="kWsGpNMQR06kXR-k-qWhyQ" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="mmPlMPjMnECVqmG5mkXJMw" visible="1" canBeVaried="1" />
-                            <MoleculeAmount id="znbTFUnnCk6LEJuB7ZDqlg" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                              <Children>
-                                <Parameter id="O08PkeohuUi_xwkUiaMUOA" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                                <Parameter id="xvbMSJAkIUO33VH_BOXNww" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DToG4VhDpUac-5LHWuZ90A" visible="0" canBeVaried="0" />
-                                <Observer id="U288iZ1DJUuhgBVhd_G7cQ" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
-                              </Children>
-                            </MoleculeAmount>
-                          </Children>
-                        </Container>
-                        <Container id="xqyjpic_fU-nSEKNKkYMGw" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="IntestinalSecretionSource" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                            <Tag value="Rectum" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="UjYDCk13c0ySi2qcfHbMHw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="dE28EI6hVk23fUjk1luoMw" visible="0" canBeVaried="0" displayUnit="l" />
-                            <Parameter id="19keXGvRgkGkbZDgVLlA9g" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="m5gWJCaKR0mYkdrFJN9OsQ" visible="1" canBeVaried="1" displayUnit="l" />
-                            <Parameter id="ARQHHUdzckSHDtLC5pZWTw" name="pH" description="pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="7.3" />
-                            <MoleculeAmount id="QVE4GWVZMEmvb2TwJk78sQ" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1" value="0" displayUnit="µmol">
-                              <Children>
-                                <Parameter id="oH5dMUCAPESvP7iYGeQQCQ" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                                <Parameter id="WUtODzeQgk25JtBektklWQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="xS7xdiryrESB-6DHK6IuAg" visible="0" canBeVaried="0" />
-                                <Observer id="FWqN-8eGvUuRYOQiDoiQhQ" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="DQ46564R0UipcLMcz9IorQ" displayUnit="µmol/l" />
-                              </Children>
-                            </MoleculeAmount>
-                          </Children>
-                        </Container>
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="0R3AH4eoIUGff0VJeZFePw" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Observer id="xKiCLwVwmEaiF-3LV46WAQ" name="Interstitial Unbound" description="Interstitial Unbound" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="ZyvJ8fAke0mbYrfSrxcACw" displayUnit="µmol/l" />
-                    <Observer id="Jb6fJ4SkDkWuA9jwEbzmKQ" name="Intracellular Unbound" description="Intracellular Unbound" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="lHCXjnyQt0Wf_kfsvc1dyw" displayUnit="µmol/l" />
-                    <Observer id="7w2St-54S0a9MBz40FNxig" name="Total Tissue (Large Intestine)" description="Mucosa and nonmucosa tissue" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" formula="qfVgYXFhbEucduXYqIuWzw" displayUnit="µmol/l" />
-                  </Children>
-                </Container>
-              </Children>
-            </Container>
-            <Container id="Rhac5tMzcE25KAdsWPtHGw" name="Liver" description="Liver" icon="Liver" mode="Logical" containerType="Organ">
-              <Tags>
-                <Tag value="TissueOrgan" />
-              </Tags>
-              <Children>
-                <Parameter id="NrOpRdlSHEGKuOVrkGJYgQ" name="Weight (tissue)" description="Weight of organ or compartment" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="uSjt8LuoBUu75Z4-7ZUOCw" visible="0" canBeVaried="1" displayUnit="kg" />
-                <Parameter id="AtgqOfsbC0O-6FFL0drZvQ" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="r6hKppO2VkWuS83bzmF1BQ" visible="1" canBeVaried="0" displayUnit="l" />
-                <Parameter id="Tnw5zfmzRE2Ylj2IsCi8lA" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="W3YX7B87ekidvBNq8dvYuQ" visible="1" canBeVaried="1" displayUnit="l/min" />
-                <Parameter id="aQEFNGVtfEuhNNiM6x5RvQ" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="bGAhSqB3sUmuhjRs59CY7Q" visible="1" canBeVaried="1" displayUnit="l/min" />
-                <Parameter id="qQkDa14WM0i2wMFmqaGS3A" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="LSHvGCmOBEascdPo-Ab-KQ" visible="1" canBeVaried="1" />
-                <Parameter id="OF5tAnY4Hk20L-iVfO7XQA" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="jdhhCNoMYE-s118HG9XzZw" visible="1" canBeVaried="1" displayUnit="l/min" />
-                <Parameter id="2mipRXFbCkCXGhbDI66xYA" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" visible="0" canBeVaried="1" value="1" displayUnit="g/cm³" />
-                <Parameter id="2CVYOFMM-ESxk8ng5Sdttg" name="EHC continuous fraction" description="Fraction of biliary secreted compound continuously entering the duodenum without being temporarily stored in the gallbladder. The fraction of hepatic bile directly entering the duodenum is species-dependent and amounts to about 30-50% in fasted humans to 100% in rats, because the rat lacks a gallbladder." persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" visible="1" canBeVaried="1" value="0" />
-                <Parameter id="-1v0ZuDr2EmI99fr1j0rDA" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.75" />
-                <Parameter id="Hbp5jRaXMU-NkUipQU6AkQ" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                <Parameter id="RLOt45oegkK9fER77gzqKA" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" visible="1" canBeVaried="1" value="3.88888888888889E-11" displayUnit="ml/min/N" />
-                <Parameter id="2uWbuWdISUK1_flVO-20Nw" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="3.3E-07" displayUnit="µm" />
-                <Parameter id="ZJEkCmjtfU-Zy-0eSXpa0g" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="9E-08" displayUnit="µm" />
-                <Parameter id="o9KzVTZPu0m2eQRiWV_NEQ" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.8" />
-                <Parameter id="O9ToKIJLxUqoiXHT_guxkA" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.069" />
-                <Parameter id="E8JifNC-C0uH0E1fQT49Ww" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0348" />
-                <Parameter id="KBu4z6S9_Eq1a76ECxDhmQ" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.17" />
-                <Parameter id="cV0uVcjZr0ar0XuK_HFo4g" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0252" />
-                <Parameter id="2-iwnCE6U0SV7yU8EZFSMA" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.184" />
-                <Parameter id="NXda-WPDRUSIzA_L_yJ5Ag" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.086" />
-                <Parameter id="U2Be6gm090CyoWn9rc6pNA" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.5" />
-                <Parameter id="4mu-HNRgUE2OVZi-_o0lPg" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.161" />
-                <Parameter id="HiM41q2VV0qpD7_uwGIi6Q" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.751" />
-                <Parameter id="kV8rG9p_PEyJ6K-x5T8egA" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.747" />
-                <Parameter id="knaEUHJ9H0SwtQYzT_F56A" name="Number of cells/g tissue" description="Number of cells per gram tissue" persistable="0" isFixedValue="0" dim="Count per mass" quantityType="Parameter" visible="0" canBeVaried="1" value="139000" displayUnit="x10^6/g" />
-                <Parameter id="S4xV0Mikf02qW-aK3pgiUA" name="Microsomal protein mass/g tissue" description="Microsomal protein content per gram tissue" persistable="0" isFixedValue="0" dim="Mass per tissue" quantityType="Parameter" visible="0" canBeVaried="1" value="0.04" displayUnit="mg/g" />
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-                <Parameter id="oPbylLP9EkiHT_cJTz-i1Q" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0232" />
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-              <Tags>
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-                <Parameter id="NdSPZvtRLkmvBtAgyaKnWA" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.75" />
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-                <Tag value="TissueOrgan" />
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-                <Parameter id="MMV3zfvVkUSrt7Wb1raR3A" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="jdhhCNoMYE-s118HG9XzZw" visible="1" canBeVaried="1" displayUnit="l/min" />
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-                <Parameter id="RIFIukhX6EmjBLIDO29rdQ" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.75" />
-                <Parameter id="ZWDBoNnk90KKFtCmo2zkgw" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                <Parameter id="s0bSYzHKTk-hX4mT4DwSLQ" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="9E-08" displayUnit="µm" />
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-                <Parameter id="k63auiKsSUKKjv6-XBvYlw" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="3.3E-07" displayUnit="µm" />
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-                    <Parameter id="YtQeNq6sh0C86sjYKUmD4A" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="BtYHf38KbE2Woag0S8zVQw" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                    <Parameter id="NjqsAMbtRUq_dUJf8N7BpQ" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="Y5i-HZk9NUeoA7UKGgQIDg" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                    <Parameter id="4oBi_NHdC0-cLTeB-5qmag" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="hKXq5MVtGkCKHD0_pgT1Kg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="jKTZ42qhLka8_mgC6s1uOA" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="p_bsa76dkkG6bsceP87FTg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="GB_QYHB21kuEXti4ZzFF7Q" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                    <Parameter id="dV0y_4yQq0SX-gAUcx0ANA" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                    <Parameter id="pJ54alklUEmpQu8wB2nGZQ" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="R_GCvNJjkEOK7WViVxWftw" visible="0" canBeVaried="0" />
-                    <Transport id="h-xm2YBifEqFQzntG8aO0w" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Transport" dimension="Amount per time" formula="RGyVpQIBIUujbx5PLyJB4w" sourceAmount="JVBHLpp8bk-YmTIxkEKXPQ" targetAmount="j-CyXHPZe0Wv2zpXdSqmOg" />
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-                <Parameter id="mMRgKleiZUCKZ2DJ5fK6XQ" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="zTjawHviokCp6BWrb8up4Q" visible="1" canBeVaried="1" displayUnit="cm²" />
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-              <Tags>
-                <Tag value="Neighborhood: Plasma / BloodCells" />
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-                <Container id="G7-Y2PNEykSD5bQ2hPWFmg" name="C1" mode="Logical" containerType="Molecule">
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-                    <Transport id="52aSObxb7EChzB2MUUIH3w" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="eOlA6dCqh0uwRhSs7h2i2Q" sourceAmount="rOGC7KehEkmFXF9mQPDiZQ" targetAmount="qMH9c4X4Ek6ugLGK4dEEug" />
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-                <Parameter id="7i-oRY-UrUireZuvzELuxw" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="q2SZupdPBk29DbFWD_wiYA" visible="1" canBeVaried="1" displayUnit="cm²" />
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-              <Tags>
-                <Tag value="Neighborhood: Interstitial / Intracellular" />
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-              <Children>
-                <Container id="PkG9K5urvkiMrBbEtELCaQ" name="C1" mode="Logical" containerType="Molecule">
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-                    <Parameter id="g2bSXHLW2UCbjj-70yqW1Q" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="Y5i-HZk9NUeoA7UKGgQIDg" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                    <Parameter id="lSw9V9j5rEeehJeJCnbDtQ" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="BtYHf38KbE2Woag0S8zVQw" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                    <Parameter id="Pl44GUMR30aZejlrudYCfQ" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="hKXq5MVtGkCKHD0_pgT1Kg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="8GCTrVIC7UObX-8zGH-PNQ" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="p_bsa76dkkG6bsceP87FTg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="t4dlGnqiIE2ihQHUjXpr-A" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                    <Parameter id="2gTKC61cUU2MhkC76i3PFw" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                    <Parameter id="_yfFL3kpzkeyfX2-EV7MZA" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="RHJFkoUWKUO_c5qodk8rdw" visible="1" canBeVaried="1" />
-                    <Parameter id="YJVxlJzXDU6PUvLRMTreLw" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="X8aa6JXQB0-b6a-LH5_Krw" visible="0" canBeVaried="1" />
-                    <Parameter id="nm3M5VxoTU2vpGs8cdWbTw" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="6G8Gj3AgAEq5Jo3c2a8Svg" visible="0" canBeVaried="0" />
-                    <Transport id="DY5x2buhcUqYh2VGgEGZmQ" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Transport" dimension="Amount per time" formula="o6QxkCBmRkqFi3GmZdSyYw" sourceAmount="LZKzN82i0E6J4Q0wAWWjGQ" targetAmount="9PKbTeAyNke-NAorSLhxfg" />
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-                <Parameter id="khVDss3k-0u3RmtQ0zrcWQ" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="BaV3JwM-4U-Jb2MKQXaY_g" visible="1" canBeVaried="1" displayUnit="cm²" />
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-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
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-              <Children>
-                <Container id="-g5jGcb_fU-cWzwavC_lLg" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="4i7XUK4ICkyTYI1EyVxd9w" name="MassTransferOrgPl2BloodPool" description="Mass transfer from organ: Plasma to Venous Blood: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="06YOub9nGkOqMJ6QI0nikw" sourceAmount="rOGC7KehEkmFXF9mQPDiZQ" targetAmount="B3lPdr5IY0uIYf2oKyowmg" />
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-            <Neighborhood id="N5h1WpjqOkmaQ31ml3_KuA" name="Brain_pls_Brain_int" description="Neighborhood between Brain/Plasma and Brain/Interstitial" mode="Logical" containerType="Other" firstNeighbor="bT3W5WSK-UqwySKFP2SkAQ" secondNeighbor="fpmoCgYiEUiOYcj3rULcTw">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Interstitial" />
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-              <Children>
-                <Container id="n5G2u5mtd0yd6D4-VMyqJw" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="mE2oi7Oxh0a4hQKRkGXQWg" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="PXcfe353tkKGkqlyd4DxqA" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                    <Parameter id="j9ruZ49bJ0eLqpMDcTw1IQ" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Bon9EHArSU6bcCi8KdWj7w" visible="1" canBeVaried="1" />
-                    <Transport id="mMEOWyCMP0e3mRmIiWcVOg" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Transport" dimension="Amount per time" formula="LOE07hp0cEaAXnDa2IBZCg" sourceAmount="rOGC7KehEkmFXF9mQPDiZQ" targetAmount="LZKzN82i0E6J4Q0wAWWjGQ" />
-                  </Children>
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-                <Parameter id="VB1Tk_MWuEiXPorRpVVDMw" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="ooNVHJv3WUKM0nfglnrDuw" visible="1" canBeVaried="1" displayUnit="cm²" />
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-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
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-                <Container id="mhW8ejSv5UWB1JCIQrDHsA" name="C1" mode="Logical" containerType="Molecule">
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-                    <Transport id="KzezxYkgx0a3AyaclqA7cQ" name="MassTransferOrgRBC2BloodPool" description="Mass transfer from organ: Blood Cells to Arterial Blood: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="G-SAJ5lGNUCBhFJmUIb4Jg" sourceAmount="qMH9c4X4Ek6ugLGK4dEEug" targetAmount="GWJuEfO1Xkqh3wAfzsLyqQ" />
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-            <Neighborhood id="76b4AEKV0kCgD0XWxp8bcg" name="Fat_pls_VenousBlood_pls" description="Neighborhood between Fat/Plasma and Venous Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="l3cprPldy0-s1EHY_moWpQ" secondNeighbor="J2AzZMiPQUibGWyUqz4XLA">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
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-              <Children>
-                <Container id="N8aYLJG5_0SYtwL1o_Yyug" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="lgEQwShRaE-EBbQ7opOsdQ" name="MassTransferOrgPl2BloodPool" description="Mass transfer from organ: Plasma to Venous Blood: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="MfpvLpacLEeQUO61eGcPLw" sourceAmount="oe9lGPCNGkOTlj2HvT3xWA" targetAmount="B3lPdr5IY0uIYf2oKyowmg" />
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-            <Neighborhood id="rVswRr6RUkivG1wZQySBMQ" name="Fat_pls_Fat_bc" description="Neighborhood between Fat/Plasma and Fat/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="l3cprPldy0-s1EHY_moWpQ" secondNeighbor="C6Aak1KuHE6WEnBWIms5EQ">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / BloodCells" />
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-              <Children>
-                <Container id="gLh3Hf8OWkWx5FLJ7lEdyQ" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="mtkrubgrT0q3-UuTs8NAOw" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="5aLIGmTAvEq-0ti5pUcgrg" sourceAmount="oe9lGPCNGkOTlj2HvT3xWA" targetAmount="8YO8dduw-0WdLQKfJY0mOg" />
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-                <Parameter id="5z-fdLCQ3E-zAzh78wbIDw" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="o8ujdUln4kO76TN-oPGOFw" visible="1" canBeVaried="1" displayUnit="cm²" />
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-              <Tags>
-                <Tag value="Neighborhood: Interstitial / Intracellular" />
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-              <Children>
-                <Container id="fcmaMPPcR0y6Lgl7VIvrqg" name="C1" mode="Logical" containerType="Molecule">
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-                    <Parameter id="9MP-tnXnj0CtmUxjnMMsEw" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="BtYHf38KbE2Woag0S8zVQw" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                    <Parameter id="EJAlu7ZXYE215B92tVQuZQ" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="Y5i-HZk9NUeoA7UKGgQIDg" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                    <Parameter id="bmw1TdrM7UehsXwxmUkbfg" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="hKXq5MVtGkCKHD0_pgT1Kg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="JgX33B-wjU6tzPQvpeH8zw" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="p_bsa76dkkG6bsceP87FTg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="K1S7APsmEkSzLLwd8Y3wFw" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                    <Parameter id="zwxSwGXA2EO0j4wmWJXLNA" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                    <Parameter id="WA2cLfGlxUi-GPeEsWbn8Q" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="X8aa6JXQB0-b6a-LH5_Krw" visible="0" canBeVaried="1" />
-                    <Parameter id="V7dQfFHBWk6G36Il1eqj4A" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="bkMaQzAXbkKZMfhu20C2dA" visible="1" canBeVaried="1" />
-                    <Parameter id="S7lAD_XgcE2ee-vbZ4wkwg" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="UvdVWmnPmk6Zrv_cuBjY9w" visible="0" canBeVaried="0" />
-                    <Transport id="VlbyIDXQO0CDqzsNdfm9yQ" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Transport" dimension="Amount per time" formula="ylhW3x4hlEmnMyz9psWc7A" sourceAmount="8bCP7EDFe0qGP2kTSb8qxQ" targetAmount="kKAxBpyyCEqnrOe1-h8AIg" />
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-                <Parameter id="yEjtoQvvNEaakGFyhvevTA" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="EBFxq6LHpkq-ARnl8hT1UA" visible="1" canBeVaried="1" displayUnit="cm²" />
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-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
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-              <Children>
-                <Container id="w9VOOYw_gUOnnUfyeqazBA" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="SiEa_C32d02MgkKDoUXexg" name="MassTransferOrgRBC2BloodPool" description="Mass transfer from organ: Blood Cells to Arterial Blood: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="j5y7xBG2ZUK8NtfyNW2h5A" sourceAmount="8YO8dduw-0WdLQKfJY0mOg" targetAmount="GWJuEfO1Xkqh3wAfzsLyqQ" />
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-              <Tags>
-                <Tag value="Neighborhood: Plasma / Interstitial" />
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-              <Children>
-                <Container id="4He7Bx_hgEyKRsLNhQInTg" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="671StCVPVka1RFwN1bUw4g" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" visible="1" canBeVaried="1" value="10" displayUnit="cm/min" />
-                    <Parameter id="gHZAPG8UR0Cb6h64OJJDjg" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Bon9EHArSU6bcCi8KdWj7w" visible="1" canBeVaried="1" />
-                    <Transport id="v52mJW6ne0SZ1CLCZqyBsQ" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Transport" dimension="Amount per time" formula="smrSXFIut0uS4zM5S43Clw" sourceAmount="oe9lGPCNGkOTlj2HvT3xWA" targetAmount="8bCP7EDFe0qGP2kTSb8qxQ" />
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-                <Parameter id="BCePykvRikCS182idagqTQ" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="afSzcwVTEUSFqHscVKHrCQ" visible="1" canBeVaried="1" displayUnit="cm²" />
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-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="h51shqN9p020lvRA_UkryQ" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="YhKSsOtY9U-NvMu-2cS79Q" name="MassTransferOrgRBC2BloodPool" description="Mass transfer from organ: Blood Cells to Arterial Blood: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="yXl9miUyXU-AWGDo1YDMdg" sourceAmount="NMsvr4OvokeBZq8LJ-XvXQ" targetAmount="GWJuEfO1Xkqh3wAfzsLyqQ" />
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-            <Neighborhood id="6LS0DlNX7kWC69EN_L7Y6A" name="Gonads_pls_VenousBlood_pls" description="Neighborhood between Gonads/Plasma and Venous Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="LjaheEHgMkKcij_K4QJW7g" secondNeighbor="J2AzZMiPQUibGWyUqz4XLA">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="SKl0wJZegkeuwqz5rbHtBw" name="C1" mode="Logical" containerType="Molecule">
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-                    <Transport id="XGpt77GjOUiyUBP98eFCaw" name="MassTransferOrgPl2BloodPool" description="Mass transfer from organ: Plasma to Venous Blood: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="zR_kHpUco06Salsl9d1-dQ" sourceAmount="7v8TrBZxj028VHiqRTbv9A" targetAmount="B3lPdr5IY0uIYf2oKyowmg" />
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-              <Tags>
-                <Tag value="Neighborhood: Plasma / Interstitial" />
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-              <Children>
-                <Container id="xWPOzh2vX0KZsaiKD8FLog" name="C1" mode="Logical" containerType="Molecule">
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-                    <Parameter id="YEykFjsNgka6ayRABr-zhg" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" visible="1" canBeVaried="1" value="10" displayUnit="cm/min" />
-                    <Parameter id="zUpyZFBo_kmKqe7iWGdXGg" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Bon9EHArSU6bcCi8KdWj7w" visible="1" canBeVaried="1" />
-                    <Transport id="V_kxrdi1o0S6MTw-zg8VPA" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Transport" dimension="Amount per time" formula="iSVK--RYskWdfoHzdXPamQ" sourceAmount="7v8TrBZxj028VHiqRTbv9A" targetAmount="cLW8f3C6Akm9Gc4EaPRBCg" />
-                  </Children>
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-                <Parameter id="nNSGK32xvEmTtnNACPWdiA" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="n5K8uWLFQEaPOHAzTn1thQ" visible="1" canBeVaried="1" displayUnit="cm²" />
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-            <Neighborhood id="8Jp8xvPkFUmOb_FtNNvvsQ" name="Gonads_pls_Gonads_bc" description="Neighborhood between Gonads/Plasma and Gonads/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="LjaheEHgMkKcij_K4QJW7g" secondNeighbor="4_tlbol5sEOUurLb-QmrqA">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / BloodCells" />
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-                <Container id="KukR0ADozkivNmSO7ZZq1g" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="Kp1J2sbhEU27Gfx9Qmt-tg" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="lfPLle5R9kOGbcQyd3yhrQ" sourceAmount="7v8TrBZxj028VHiqRTbv9A" targetAmount="NMsvr4OvokeBZq8LJ-XvXQ" />
-                  </Children>
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-                <Parameter id="U9E3b1My00WNMnSGJf4xlw" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="XOsBORdt906NTQYSB-ajNg" visible="1" canBeVaried="1" displayUnit="cm²" />
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-              <Tags>
-                <Tag value="Neighborhood: Interstitial / Intracellular" />
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-              <Children>
-                <Container id="TbF2Cds2U0yL1UugFbI7Tg" name="C1" mode="Logical" containerType="Molecule">
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-                    <Parameter id="dszkXr647UWwckJqm6VjTQ" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                    <Parameter id="KKBYMx7100emQxw2ofnIZw" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                    <Parameter id="51vVpb_suEW7qKOY5xPFhQ" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Kq38vAGPT0OwYrOZNLodkg" visible="1" canBeVaried="1" />
-                    <Parameter id="BkC_TQgjz0uSKLoTaLBEAw" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="X8aa6JXQB0-b6a-LH5_Krw" visible="0" canBeVaried="1" />
-                    <Parameter id="7WxgVeonLECc9Gr8M-QjUw" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="hKXq5MVtGkCKHD0_pgT1Kg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="N__7fpLEJ0eRXtaTfxQSyg" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="Y5i-HZk9NUeoA7UKGgQIDg" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                    <Parameter id="kpmuDa1xzUKBYbBxDOu2-w" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="p_bsa76dkkG6bsceP87FTg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="ZRvPYwhlJUmhDUqM59bJWA" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="BtYHf38KbE2Woag0S8zVQw" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                    <Parameter id="67ZiY0v91EOH2yaGlmkQjw" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="5VeZ5UY5vUq35ulK2FxZcQ" visible="0" canBeVaried="0" />
-                    <Transport id="YpXMbAsV_0GWlQucCpw3SQ" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Transport" dimension="Amount per time" formula="g2Iwo2sUVk-0UviKYrTt6A" sourceAmount="cLW8f3C6Akm9Gc4EaPRBCg" targetAmount="w376tfX_LEqdGN6dZkfsCw" />
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-                <Parameter id="LNAoCIjrUkmG8pbL_ucesA" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="GMkcmIJge0-EQsV7a2yVFQ" visible="1" canBeVaried="1" displayUnit="cm²" />
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-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
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-              <Children>
-                <Container id="lPDoCpI8lkavXJc-PMRfUw" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="wc8VYjtm4kKNOfynXKYRAw" name="MassTransferOrgRBC2BloodPool" description="Mass transfer from organ: Blood Cells to Arterial Blood: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="qJ1gFzYRFkaM_xVYIY8ZPw" sourceAmount="Obwdz__ceEWQHALue4zdrw" targetAmount="GWJuEfO1Xkqh3wAfzsLyqQ" />
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-              <Tags>
-                <Tag value="Neighborhood: Interstitial / Intracellular" />
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-              <Children>
-                <Container id="2hAbG86bckWZrGPGbOcBwA" name="C1" mode="Logical" containerType="Molecule">
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-                    <Parameter id="RttIwYWGYUuUQDONZk7jjQ" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="BtYHf38KbE2Woag0S8zVQw" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                    <Parameter id="bgCcQsOpZkOYjx8nxl-bAw" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="Y5i-HZk9NUeoA7UKGgQIDg" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                    <Parameter id="g55oKFCZv06DHKJ9W_TZdA" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="hKXq5MVtGkCKHD0_pgT1Kg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="GXaeEQNyhEW7tP7S3_cznQ" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="p_bsa76dkkG6bsceP87FTg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="lgQq340CEEGaeXztbLvJQA" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                    <Parameter id="ge258-7hZUCQKs20hrN1bA" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                    <Parameter id="eVjRFzhdpUOZykQoS8nDAw" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="28yZHpB_wEyTG5lWceWO8g" visible="1" canBeVaried="1" />
-                    <Parameter id="1C1ygFOzCE-4H25w_hnAYg" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="X8aa6JXQB0-b6a-LH5_Krw" visible="0" canBeVaried="1" />
-                    <Parameter id="lZiOtd1oUES5giWoToX8kQ" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="afu_TS7MBUyD6OoeTO4Jcg" visible="0" canBeVaried="0" />
-                    <Transport id="rW8oDaZP8Ei83EdQHkyYzg" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Transport" dimension="Amount per time" formula="X9IqIG_peESyHd7QCwEWHw" sourceAmount="aIf68iyeP0-G3GIM9GCG-g" targetAmount="rg9PTo0oHk6Ikb4dbfWN3g" />
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-                <Parameter id="0a_Cmub6z0CMe7EEIvtJ1w" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="MFrxF-tdR0aLZJd_oDWD_w" visible="1" canBeVaried="1" displayUnit="cm²" />
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-              <Tags>
-                <Tag value="Neighborhood: Plasma / BloodCells" />
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-              <Children>
-                <Container id="ltOUl8jLXk2Iynk_9Y-Kxw" name="C1" mode="Logical" containerType="Molecule">
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-                    <Transport id="O86S-9YVOkeFt97oEAYPrQ" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="2Qqvzf9Cg0CDvPykINwhrA" sourceAmount="qoaU-KhmBkSuINyqySeM2A" targetAmount="Obwdz__ceEWQHALue4zdrw" />
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-                <Parameter id="yyy_nqI7iE6yvIIPPpEHEw" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="6ZB1BpA7wEK9xgaDzhEzLw" visible="1" canBeVaried="1" displayUnit="cm²" />
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-              <Tags>
-                <Tag value="Neighborhood: Plasma / Interstitial" />
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-              <Children>
-                <Container id="8QlR7KrQr0K5rOaGiAnplQ" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="iOBOu5-0PkGjKa4CGXldgQ" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" visible="1" canBeVaried="1" value="10" displayUnit="cm/min" />
-                    <Parameter id="yCLUAkQ2-k-mIqOXLQzsbA" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Bon9EHArSU6bcCi8KdWj7w" visible="1" canBeVaried="1" />
-                    <Transport id="GG_dZyfE40K96oXo23SBxg" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Transport" dimension="Amount per time" formula="zwFLIiTmsUOo9wr_jUmpkw" sourceAmount="qoaU-KhmBkSuINyqySeM2A" targetAmount="aIf68iyeP0-G3GIM9GCG-g" />
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-                <Parameter id="pG59kOAcHkeSTiYvYCsCYw" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="RElvFiBLr02yPRZvyaQKNw" visible="1" canBeVaried="1" displayUnit="cm²" />
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-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
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-                <Container id="XalH85j7M0a2_9a2YeSWXw" name="C1" mode="Logical" containerType="Molecule">
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-                    <Transport id="1IlBRoO2R0yRUnO9Jp-_Wg" name="MassTransferOrgPl2BloodPool" description="Mass transfer from organ: Plasma to Venous Blood: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="stoLMCDlQ0uoq2i_14trBA" sourceAmount="qoaU-KhmBkSuINyqySeM2A" targetAmount="B3lPdr5IY0uIYf2oKyowmg" />
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-            <Neighborhood id="35hrv8kBSk-NxZywqtcG1g" name="Kidney_bc_VenousBlood_bc" description="Neighborhood between Kidney/Blood Cells and Venous Blood/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="fhpOPLdsBEC4DtZUc1zwcA" secondNeighbor="HLhY21FI2UuJWgRMTu6RlA">
-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
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-                <Container id="Kb0jAIBz3EK-CDrKlURNIw" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="FIJXOz0Yz0CBVJ_O4QKVjw" name="MassTransferOrgRBC2BloodPool" description="Mass transfer from organ: Blood Cells to Arterial Blood: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="mt54uViaJEiXYrMsOLDjIA" sourceAmount="s0ARpvfc_kCXvSg1uyJo7w" targetAmount="GWJuEfO1Xkqh3wAfzsLyqQ" />
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-                <Tag value="Neighborhood: Interstitial / Intracellular" />
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-              <Children>
-                <Container id="IROdJLVpfkaGxxaF-hAnAw" name="C1" mode="Logical" containerType="Molecule">
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-                    <Parameter id="I4tlIlPOKUuUTeh3PWzqag" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
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-                    <Parameter id="kfB4OwIEyk2VfE2_stdMtw" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="Y5i-HZk9NUeoA7UKGgQIDg" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                    <Parameter id="dlH8IyZyXE-t-8JsynT6zw" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="p_bsa76dkkG6bsceP87FTg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="tL3iShBRf0-roomYwCYA3g" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                    <Parameter id="YPwwschlvEKmc_UvZK49uA" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="avKhs_MMbECZxeGuujMtmg" visible="1" canBeVaried="1" />
-                    <Parameter id="aPRad8h8_UCwjYKDoeVJ7w" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="X8aa6JXQB0-b6a-LH5_Krw" visible="0" canBeVaried="1" />
-                    <Parameter id="P_nQUf1uLUKSQzLXBkmv7Q" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="hKXq5MVtGkCKHD0_pgT1Kg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="aFqfY7BNdUiexNCgqYSk6g" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="cPlEEKQG0kuLcnac-J1agA" visible="0" canBeVaried="0" />
-                    <Transport id="PKm2H7YCiUy5PAKOxOBC2g" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Transport" dimension="Amount per time" formula="YYBOHe_kj0maoyuSMNZa1A" sourceAmount="rLePgF_TyEiRY-5MFS7gYQ" targetAmount="awwqxHaZjk6cVuYVx6Qo6Q" />
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-                <Parameter id="BcIPHsGU8EeQCETgT_8fcg" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="1YOQD4cfSU-pCHJvjIRkXA" visible="1" canBeVaried="1" displayUnit="cm²" />
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-              <Tags>
-                <Tag value="Neighborhood: Intracellular / Urine" />
-              </Tags>
-              <Children>
-                <Container id="3CtVaZ-GEUKHQ1485UTjJQ" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="wYjmuFY640GA5lMwuzMgNA" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="VXEUQtjzoEuA_-UWXnE8rw" visible="0" canBeVaried="1" />
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-            <Neighborhood id="bUln7fDl30-xZMH24fr-hw" name="Kidney_pls_Kidney_bc" description="Neighborhood between Kidney/Plasma and Kidney/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="eUFCZIU4ekuNusmv0rogQA" secondNeighbor="fhpOPLdsBEC4DtZUc1zwcA">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="HI5P-eaYt0iVywRcZTfCEA" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="9CSyUPovuEq0_ugK9BL9Ig" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="IrMTD2KvL0OphA_NDecqJg" sourceAmount="E1GgL5W3o0mtgLyXCveGWQ" targetAmount="s0ARpvfc_kCXvSg1uyJo7w" />
-                  </Children>
-                </Container>
-                <Parameter id="Uf5OfL0oaUW0HfrViEFYHw" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="HrU4WdrJYkSJoZwAobB80A" visible="1" canBeVaried="1" displayUnit="cm²" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="kCji9qdFMUeQZqOjF3SL9w" name="Kidney_pls_Kidney_int" description="Neighborhood between Kidney/Plasma and Kidney/Interstitial" mode="Logical" containerType="Other" firstNeighbor="eUFCZIU4ekuNusmv0rogQA" secondNeighbor="qJpKdMNBEE66ash196CN-g">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Interstitial" />
-              </Tags>
-              <Children>
-                <Container id="93aUrfrvBUSxkpEPEF-xSw" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="9CO5eqcZ2UW9EpRL1TNiKw" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" visible="1" canBeVaried="1" value="10" displayUnit="cm/min" />
-                    <Parameter id="_eFU-yKXdEGBK8cY2lKn2w" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Bon9EHArSU6bcCi8KdWj7w" visible="1" canBeVaried="1" />
-                    <Transport id="nb4c0iNoVE2xkneJb9DGSw" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Transport" dimension="Amount per time" formula="OYtLt-SQLEOP3Q4dpYPF4w" sourceAmount="E1GgL5W3o0mtgLyXCveGWQ" targetAmount="rLePgF_TyEiRY-5MFS7gYQ" />
-                  </Children>
-                </Container>
-                <Parameter id="LgVCFL9IME2tGU03s_q_EA" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="DyMpBO0dlUGvZ139HnB02g" visible="1" canBeVaried="1" displayUnit="cm²" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="zSy5uf3EyEGdkEVkCPeknA" name="Kidney_pls_Kidney_ur" description="Neighborhood between Kidney/Plasma and Kidney/Urine" mode="Logical" containerType="Other" firstNeighbor="eUFCZIU4ekuNusmv0rogQA" secondNeighbor="s0wdzco21kO0XF6OWbSXow">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Urine" />
-              </Tags>
-              <Children>
-                <Container id="NzdHf2U29EK87F0pZ9KlDA" name="C1" mode="Logical" containerType="Molecule" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="ZLRyxzPZfEejT__x9ls0-Q" name="UpperJejunum_pls_PortalVein_pls" description="Neighborhood between Upper Jejunum/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="Mqff24qDg0q3J5knCoXTZw" secondNeighbor="-zX9e5Gif0qLF9-buV_xlA">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="1IkPf1j3kkaT19-K9c07-g" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="ukE3fj4-e0W_8LwvFL5Oqg" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="PKCiN5wizUqVY5mFTJrSAg" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Transport id="VFVxYri4_kG-6uFxygoAuw" name="MassTransferMucosaToPvePlasma" description="Mass transfer from Mucosa:Plasma To Portal Vein: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="X_ChVZC6jkCL-Jm44_dKXw" sourceAmount="PMNegnlhr0CXVnvfwhXU7g" targetAmount="hqBDuJ9j9Eqjy73I0KZSUA" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="yYtH-uUUgUSjrtyK-tzMWg" name="Lumen_uje_UpperJejunum_cell" description="Neighborhood between Lumen/Upper Jejunum and Mucosa/Upper Jejunum/Intracellular" mode="Logical" containerType="Other" firstNeighbor="CiHSzBkCCUudCrF-9qgurw" secondNeighbor="V6G7I9JiAUeouIcb-9qK3g">
-              <Tags>
-                <Tag value="Neighborhood: UpperJejunum / Intracellular" />
-              </Tags>
-              <Children>
-                <Container id="vI597wDO90ykKN3YnxXWGg" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="2cjwf94OhkOtSO41bvzb4A" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="Un4CTUv5OEqa_cWxTEk6Pw" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="H1lzWD5ErUePht8BsU8uVA" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="A90y53VdVUerRM6490D5aw" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="0Jnh6wMV2UWmTzIgNS-3QA" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="qr_x2cq_Y0C6Ur-VSCP4AQ" visible="0" canBeVaried="0" />
-                    <Parameter id="SGhUVxGBEEq9iGIiU754aQ" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="ezAHDPnckEKYf8L1jOtGfw" visible="0" canBeVaried="0" />
-                    <Parameter id="VpbIk98JGU2EW9rQL6p65w" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="Q_dCxqA6tUmASMG13Y4Ryw" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="I1JzH53nxUqQBb8fsZmpPg" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="bOPO_JT8sEOF6PITZSGGVg" visible="0" canBeVaried="0" />
-                    <Parameter id="mRD0WqBDGkO-kBOKgDBJPg" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="aZYSS2yfyEqUEbGBDu38yg" visible="0" canBeVaried="0" />
-                    <Parameter id="Avndg_hHkk66Kn-WrFAt8g" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="2zimE-N2h0ajj62_0OpSxg" visible="0" canBeVaried="0" />
-                    <Parameter id="hecRxC7DUEGsDu7BKHEKpQ" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="6GPVjBLNFkKAA-LvCM11iQ" visible="0" canBeVaried="1" />
-                    <Parameter id="GNYugU7wWkObIlLVqF9Brw" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="TYANm0i6YUGgusd5XfO3Eg" visible="0" canBeVaried="0" />
-                    <Parameter id="wnu9LZN3NkOC9T9SyMS4-Q" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="HapbqTMKMUeiSlftTWOgog" visible="0" canBeVaried="0" />
-                    <Parameter id="3Pe1-AVGqEymSakYpfaGmw" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="QULpvKE_DkWTRmFwKaRm4g" visible="0" canBeVaried="0" />
-                    <Parameter id="safCSvOqAU2e8zpKpjAazg" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="0IIh6FJV0UKyrimES0f1xg" visible="0" canBeVaried="0" />
-                    <Parameter id="R2U8aIneUU-05D4KUNkaJA" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="KQgllSQtqk2EfhX37WilDQ" visible="0" canBeVaried="0" />
-                    <Parameter id="E5aJFwlD_EOvxdFBrhZNrg" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="aWekJ2NVAECIIbxJKJ8L5g" visible="0" canBeVaried="0" />
-                    <Parameter id="38b0nC5gp0KfTI9r6cPyng" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="3xvkxp6qK06bn4DgEtYULA" visible="0" canBeVaried="0" />
-                    <Parameter id="WN0J4XxA5UGvEfPmpIrj7A" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Iph7YhQ5KUmsZWUX2Xf2Wg" visible="0" canBeVaried="0" />
-                    <Parameter id="tPBHfD_9jk6SU2DyMEyD3w" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="2IVWcgM31UCSVl8zMDnDhw" visible="0" canBeVaried="0" />
-                    <Parameter id="IoUNpDVoAUSr5txUaev0vA" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DNGx_vFWp0KdOb7CGcoTLQ" visible="0" canBeVaried="0" />
-                    <Parameter id="-1n-xPlebka2Sjpn5pcMWw" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="LcUCvhU3W0udtbpS1KVhEQ" visible="0" canBeVaried="0" />
-                    <Parameter id="pLLeZiR6xk2aiTNiNwPVWA" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="FRFLar2u6UCfitupmR1dLw" visible="0" canBeVaried="0" />
-                    <Parameter id="hjf5DLFSc0CSf6_WkhfcKw" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="_83Rzqiye0Gy-hxsn6fgWQ" visible="0" canBeVaried="0" />
-                    <Parameter id="0Y4I4jMB902SacsZm6BV3Q" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="h2pHx5nvbUa67_2sS2-RkQ" visible="0" canBeVaried="0" />
-                    <Parameter id="JXkyBVdKcUKw3SvSRXLIfA" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="PEhoVdLppU-G3xULjX_71g" visible="0" canBeVaried="0" />
-                    <Parameter id="k45LAc9OhEOSpL5_qGMBIw" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="pGvG5UNdC0Sot3_d3Qdvag" visible="0" canBeVaried="0" />
-                    <Parameter id="TOSixYUwlEm8TRn78clmgg" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="jJfeJ2YxEki9TK9XP6uUMA" visible="0" canBeVaried="0" />
-                    <Parameter id="bDdqA3mXKE2hlvSbZLuHFg" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DNF0kWPUFk-rtSd0Ng1Mkw" visible="0" canBeVaried="0" />
-                    <Parameter id="GCOcn9QP8kGeXbBR8_V0OA" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="gxoZyuApjEuzsuLtZuZWmQ" visible="0" canBeVaried="0" />
-                    <Parameter id="LwEmxmxvOk-Y5BWyPMY8_Q" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="7NEiCDSKM0i6GhEpoWb-Mw" visible="0" canBeVaried="0" />
-                    <Transport id="NggnlRyKIU6XPU3GO1IzEg" name="DrugAbsorption_trans" description="Drug absorption transcellular" mode="Logical" containerType="Transport" dimension="Amount per time" formula="Tdt4nnPeT0-VOCfzEJMsbw" sourceAmount="V3v2rXqlRkujCVZ10rY3Ew" targetAmount="zqzRvmsGnUGFDX4cd4aGFQ">
-                      <Children>
-                        <Parameter id="fjeNAoL04UOdZukpGzR8rg" name="ProcessRate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="Tdt4nnPeT0-VOCfzEJMsbw" visible="0" canBeVaried="1" displayUnit="µmol/min">
-                          <Tags>
-                            <Tag value="DrugAbsorption_trans" />
-                            <Tag value="ProcessRate" />
-                            <Tag value="C1" />
-                            <Tag value="Lumen_uje_UpperJejunum_cell" />
-                            <Tag value="Passive" />
-                          </Tags>
-                        </Parameter>
-                      </Children>
-                    </Transport>
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="BLvKHvfCvkuhds4aeORxew" name="Lumen_uje_UpperJejunum_pls" description="Neighborhood between Lumen/Upper Jejunum and Mucosa/Upper Jejunum/Plasma" mode="Logical" containerType="Other" firstNeighbor="CiHSzBkCCUudCrF-9qgurw" secondNeighbor="Mqff24qDg0q3J5knCoXTZw">
-              <Tags>
-                <Tag value="Neighborhood: UpperJejunum / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="6r47bpgG3k6LlQwgjGajsA" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="itPW0qPLME-o5cXpns3l6g" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="9iS9xCIJhESmNQVTrtJjPA" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="D-aD6gpL8UKLResohZLo4A" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="REII40_qmUSHw_LndjzDZw" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="3b5v95MNtE-sPVN6JG_2Tg" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="mjhQ-vpilkOE45QyIjxGrw" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Transport id="67Q_ZYz3kEG8E5HoM52vaQ" name="DrugAbsorption_para" description="Drug absorption paracellular" mode="Logical" containerType="Transport" dimension="Amount per time" formula="VkiYHcgVzES3s9uhrck6-g" sourceAmount="V3v2rXqlRkujCVZ10rY3Ew" targetAmount="PMNegnlhr0CXVnvfwhXU7g">
-                      <Children>
-                        <Parameter id="cbpMZKRJJUGmKYCl9ksCNQ" name="ProcessRate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="VkiYHcgVzES3s9uhrck6-g" visible="0" canBeVaried="1" displayUnit="µmol/min">
-                          <Tags>
-                            <Tag value="DrugAbsorption_para" />
-                            <Tag value="ProcessRate" />
-                            <Tag value="C1" />
-                            <Tag value="Lumen_uje_UpperJejunum_pls" />
-                            <Tag value="Passive" />
-                          </Tags>
-                        </Parameter>
-                      </Children>
-                    </Transport>
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="mRnd4O-vPU6HA-Fove8xpg" name="UpperJejunum_bc_PortalVein_bc" description="Neighborhood between Upper Jejunum/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="BiBid5i4Sk2EK94scFpeHw" secondNeighbor="V3IajphOTUWt3a2j9_LOZA">
-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="DvyGBmFybEidTZNMso0l7A" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="WONU0RmJTEqNWiUoi7wlkw" name="Mass transfer rate (mucosa to portal vein blood cells)" description="Mass transfer rate (mucosa to portal vein blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="iWxIyLeN6EOXrbiSubK04g" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Transport id="jytIB5yJEkKocie6n3yttQ" name="MassTransferMucosaToPveBC" description="Mass transfer from Mucosa:Blood Cells To Portal Vein: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="g_h_KvdyD0WW-bKowtXU9A" sourceAmount="RgAh2V1O4EKEVX6UAhe4zQ" targetAmount="3A4PxVITtUOpr85RBMQZlg" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="UotOSK9Jk06fxExR8_lvHA" name="Kidney_pls_VenousBlood_pls" description="Neighborhood between Kidney/Plasma and Venous Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="eUFCZIU4ekuNusmv0rogQA" secondNeighbor="J2AzZMiPQUibGWyUqz4XLA">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="Fvb0rbuJDUWEMXYUkcTO2Q" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="Kuti3D45KEGawKZYlfb68g" name="MassTransferOrgPl2BloodPool" description="Mass transfer from organ: Plasma to Venous Blood: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="716JyMTLCk2V_HA8FfYKNA" sourceAmount="E1GgL5W3o0mtgLyXCveGWQ" targetAmount="B3lPdr5IY0uIYf2oKyowmg" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="S_Y3q597TEyFvzQ4szqNkg" name="Lumen_uil_Lumen_lil" description="Neighborhood between Lumen/Upper Ileum and Lumen/Lower Ileum" mode="Logical" containerType="Other" firstNeighbor="Ybii6aaw1UeIsuUX1COdYA" secondNeighbor="igIrhkz7s0ehw7sHmKiBCg">
-              <Tags>
-                <Tag value="Neighborhood: UpperIleum / LowerIleum" />
-              </Tags>
-              <Children>
-                <Container id="S-WcdUPw8keDqV0yYe5O_w" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="F9MOA4xYQUGSOFlAbu9Ifw" name="LumenDrugTransport_lil" description="Lumen drug transport from Upper Ileum to Lower Ileum" mode="Logical" containerType="Transport" dimension="Amount per time" formula="6wS9svW1c0aBkzlA38kViA" sourceAmount="xrlOSQNSBk-WGtZ7E-tEYw" targetAmount="yw7rzbgJB0-l91_K8hz0sQ" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="TUmdlLHprEuyM5T6EUO10g" name="Lumen_sto_Lumen_duo" description="Neighborhood between Lumen/Stomach and Lumen/Duodenum" mode="Logical" containerType="Other" firstNeighbor="ioSVGmyZ-kaEQr2x4ccL0Q" secondNeighbor="RBDgGJ__rUCEJi-Z5h0eyg">
-              <Tags>
-                <Tag value="Neighborhood: Stomach / Duodenum" />
-              </Tags>
-              <Children>
-                <Container id="yYZl6KtwGk2qE8rIqdAWqA" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="oL9meknv5k2w__NiDl-KRw" name="Oral mass absorbed" description="Oral mass absorbed from Lumen into mucosa" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" formula="ubJru2ZxSkiyVRzC7EU9dw" visible="0" canBeVaried="0" displayUnit="µmol" />
-                    <Transport id="rVHwii0WiUCo4mPta9TUAw" name="LumenDrugTransport_duo" description="Lumen drug transport from Stomach to Duodenum" mode="Logical" containerType="Transport" dimension="Amount per time" formula="0HbRu9o2yEyST0m29X4mSQ" sourceAmount="r-aj2d-zBEqErgcKF5e5cw" targetAmount="BaeHcf6VhUyw3ftOPt1iIg" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="k8Oz_04UwEyiSHWxw1K7Mg" name="Lumen_duo_Lumen_uje" description="Neighborhood between Lumen/Duodenum and Lumen/Upper Jejunum" mode="Logical" containerType="Other" firstNeighbor="RBDgGJ__rUCEJi-Z5h0eyg" secondNeighbor="CiHSzBkCCUudCrF-9qgurw">
-              <Tags>
-                <Tag value="Neighborhood: Duodenum / UpperJejunum" />
-              </Tags>
-              <Children>
-                <Container id="ZOfrXN57q0uQQqFj5l6HAQ" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="KPvaFfmswUaB1suam4RpEA" name="LumenDrugTransport_uje" description="Lumen drug transport from Duodenum to Upper Jejunum" mode="Logical" containerType="Transport" dimension="Amount per time" formula="ffRcFOu61ka3rt87-1AqcA" sourceAmount="BaeHcf6VhUyw3ftOPt1iIg" targetAmount="V3v2rXqlRkujCVZ10rY3Ew" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="6IAQD43KoEmlVaFp5YKOUw" name="Lumen_lje_Lumen_uil" description="Neighborhood between Lumen/Lower Jejunum and Lumen/Upper Ileum" mode="Logical" containerType="Other" firstNeighbor="MLkuT5b_ikmcYGRo2SAH3w" secondNeighbor="Ybii6aaw1UeIsuUX1COdYA">
-              <Tags>
-                <Tag value="Neighborhood: LowerJejunum / UpperIleum" />
-              </Tags>
-              <Children>
-                <Container id="5xuLu5B3t0eiKNnt4g2l9Q" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="PIa39JHpn0uk9Mranan4ig" name="LumenDrugTransport_uil" description="Lumen drug transport from Lower Jejunum to Upper Ileum" mode="Logical" containerType="Transport" dimension="Amount per time" formula="nqTWtz3Uk0-wuaJ1jJ3YRQ" sourceAmount="Cuam5DbmZ0uqXwc9apFicg" targetAmount="xrlOSQNSBk-WGtZ7E-tEYw" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="XMMk_5hea06e4P2zciRwrQ" name="LowerJejunum_bc_PortalVein_bc" description="Neighborhood between Lower Jejunum/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="kDMQj4cgPkq4YoBI6vj_HA" secondNeighbor="V3IajphOTUWt3a2j9_LOZA">
-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="Ov6KEeyre0u5GnSScEyl7w" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="KyPQQn9VBU-Gtp2eR1Mpww" name="Mass transfer rate (mucosa to portal vein blood cells)" description="Mass transfer rate (mucosa to portal vein blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="-q6YmB7yWkexf1C7dzr2YQ" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Transport id="KOpDqDwzHkeJulJZjDyQWg" name="MassTransferMucosaToPveBC" description="Mass transfer from Mucosa:Blood Cells To Portal Vein: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="eu-y3O6a_Ui6vGmJfwW9Aw" sourceAmount="6Aqs6_wfI0OKiplexvNuNQ" targetAmount="3A4PxVITtUOpr85RBMQZlg" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="QqjGmc8Z2U6iuG5A3TusSA" name="Lumen_lil_Lumen_cae" description="Neighborhood between Lumen/Lower Ileum and Lumen/Cecum" mode="Logical" containerType="Other" firstNeighbor="igIrhkz7s0ehw7sHmKiBCg" secondNeighbor="jlQkJ9VHjEatlpKzMFmnlw">
-              <Tags>
-                <Tag value="Neighborhood: LowerIleum / Caecum" />
-              </Tags>
-              <Children>
-                <Container id="2_MkOShZAUenxuqpi9iEhw" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="KXK_cerR8kaxTAXPPBrnZg" name="LumenDrugTransport_cae" description="Lumen drug transport from Lower Ileum to Cecum" mode="Logical" containerType="Transport" dimension="Amount per time" formula="w6MTMOiAPkKvUPlJLjIo9Q" sourceAmount="yw7rzbgJB0-l91_K8hz0sQ" targetAmount="Qnj6YM6q_kSvSvGmWycE8g" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="rS1ii0EhNkC8_Oo2KKpsLg" name="Lumen_rect_Lumen_fec" description="Neighborhood between Lumen/Rectum and Lumen/Feces" mode="Logical" containerType="Other" firstNeighbor="eprwABQUEkOQApydkOYKug" secondNeighbor="IT6A3BRgbUSfIKDt5ltCRQ">
-              <Tags>
-                <Tag value="Neighborhood: Rectum / Feces" />
-              </Tags>
-              <Children>
-                <Container id="o_Iq4QUnCUOMjocF9_kt3Q" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="vG73VtohbUuK6x-6AUuETQ" name="LumenDrugTransport_fec" description="Lumen drug transport from Rectum to Feces" mode="Logical" containerType="Transport" dimension="Amount per time" formula="kw1UDji_uk6NiJHxcOPAEw" sourceAmount="2kdpKYdY3EeBvJPRNS1TEg" targetAmount="wdk5emL920WOkPCvQGJU-Q" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="kO70nkvEMkmYWtYiM9zZWA" name="Lumen_colasc_Lumen_coltrans" description="Neighborhood between Lumen/Colon Ascendens and Lumen/Colon Transversum" mode="Logical" containerType="Other" firstNeighbor="jhPiKsemqE2D9wuuFrqxsw" secondNeighbor="uB1rpzG6qkapR36UK4VYNQ">
-              <Tags>
-                <Tag value="Neighborhood: ColonAscendens / ColonTransversum" />
-              </Tags>
-              <Children>
-                <Container id="UYDuV0qVUE-U1K9tBa38KA" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="v5HlZri3UU2AhSWZp5WboA" name="LumenDrugTransport_coltrans" description="Lumen drug transport from Colon Ascendens to Colon Transversum" mode="Logical" containerType="Transport" dimension="Amount per time" formula="tPGnoB3RPEqahfqvz4OYPQ" sourceAmount="mgzsCzTwXkGLoEv-ZBAnNQ" targetAmount="B3i4ajvEPkWwF-QJhPT-RA" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="u7FcWPv9C0uHwtT-zRqWHw" name="Lumen_coltrans_Lumen_coldesc" description="Neighborhood between Lumen/Colon Transversum and Lumen/Colon Descendens" mode="Logical" containerType="Other" firstNeighbor="uB1rpzG6qkapR36UK4VYNQ" secondNeighbor="Tizt5eh3cUGAxWKaiYKVQw">
-              <Tags>
-                <Tag value="Neighborhood: ColonTransversum / ColonDescendens" />
-              </Tags>
-              <Children>
-                <Container id="foQHR26Dy0uXtJT9pcS2pA" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="nbXc7zccPUGvSPuNjXMAcQ" name="LumenDrugTransport_coldesc" description="Lumen drug transport from Colon Transversum to Colon Descendens" mode="Logical" containerType="Transport" dimension="Amount per time" formula="TCLqsm-Cak-IXlDWa0gWDQ" sourceAmount="B3i4ajvEPkWwF-QJhPT-RA" targetAmount="yiZ323gtz0WRt_37u8tDPQ" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="lk8YYuPjJ0i9M_Cyt3hPvA" name="Lumen_coldesc_Lumen_colsigm" description="Neighborhood between Lumen/Colon Descendens and Lumen/Colon Sigmoid" mode="Logical" containerType="Other" firstNeighbor="Tizt5eh3cUGAxWKaiYKVQw" secondNeighbor="FF0ppGi5GkaCMtFrfbD1kA">
-              <Tags>
-                <Tag value="Neighborhood: ColonDescendens / ColonSigmoid" />
-              </Tags>
-              <Children>
-                <Container id="t_qERdQ-y0yBS-XBxNmS5w" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="80pqDBu4mUmKJB6BvZDsWg" name="LumenDrugTransport_colsigm" description="Lumen drug transport from Colon Descendens to Colon Sigmoid" mode="Logical" containerType="Transport" dimension="Amount per time" formula="bvzHHTVaPEyzrIwkMAvPSA" sourceAmount="yiZ323gtz0WRt_37u8tDPQ" targetAmount="jIGCgtwn-U2Oqcv2W4G-ZQ" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="NhQ7z6j08USdZy3iOUJhnA" name="Lumen_colsigm_Lumen_rect" description="Neighborhood between Lumen/Colon Sigmoid and Lumen/Rectum" mode="Logical" containerType="Other" firstNeighbor="FF0ppGi5GkaCMtFrfbD1kA" secondNeighbor="eprwABQUEkOQApydkOYKug">
-              <Tags>
-                <Tag value="Neighborhood: ColonSigmoid / Rectum" />
-              </Tags>
-              <Children>
-                <Container id="g1zjNOCeVUGJgcfKYtEtHQ" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="ydJkuN3P9EGg4XaL7mEdeA" name="LumenDrugTransport_rect" description="Lumen drug transport from Colon Sigmoid to Rectum" mode="Logical" containerType="Transport" dimension="Amount per time" formula="SiOkN3wPk0O5sPFJsIhffw" sourceAmount="jIGCgtwn-U2Oqcv2W4G-ZQ" targetAmount="2kdpKYdY3EeBvJPRNS1TEg" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="fLWu6ptixUOv-qwPjJXxhw" name="Lumen_uje_Lumen_lje" description="Neighborhood between Lumen/Upper Jejunum and Lumen/Lower Jejunum" mode="Logical" containerType="Other" firstNeighbor="CiHSzBkCCUudCrF-9qgurw" secondNeighbor="MLkuT5b_ikmcYGRo2SAH3w">
-              <Tags>
-                <Tag value="Neighborhood: UpperJejunum / LowerJejunum" />
-              </Tags>
-              <Children>
-                <Container id="oa6OL4YXS0eB_BeMjb0HsA" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="DcHI_mixIUOBTzQ_ZJe9cA" name="LumenDrugTransport_lje" description="Lumen drug transport from Upper Jejunum to Lower Jejunum" mode="Logical" containerType="Transport" dimension="Amount per time" formula="Ao23g7a6G0eOkw5_gGkXNw" sourceAmount="V3v2rXqlRkujCVZ10rY3Ew" targetAmount="Cuam5DbmZ0uqXwc9apFicg" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="bvCWcfkxx0uFk2baVlklig" name="Lumen_cae_Lumen_colasc" description="Neighborhood between Lumen/Cecum and Lumen/Colon Ascendens" mode="Logical" containerType="Other" firstNeighbor="jlQkJ9VHjEatlpKzMFmnlw" secondNeighbor="jhPiKsemqE2D9wuuFrqxsw">
-              <Tags>
-                <Tag value="Neighborhood: Caecum / ColonAscendens" />
-              </Tags>
-              <Children>
-                <Container id="Hx8zrt-RKUWya51ujXF3MQ" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="3lUcpPTMG0aQMgc-XjQY4A" name="LumenDrugTransport_colasc" description="Lumen drug transport from Cecum to Colon Ascendens" mode="Logical" containerType="Transport" dimension="Amount per time" formula="HRuLTkmUJ0-J02Ale_W-RQ" sourceAmount="Qnj6YM6q_kSvSvGmWycE8g" targetAmount="mgzsCzTwXkGLoEv-ZBAnNQ" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="H5J1L_v1q0GXPKvQ18zg1Q" name="Lumen_lje_LowerJejunum_pls" description="Neighborhood between Lumen/Lower Jejunum and Mucosa/Lower Jejunum/Plasma" mode="Logical" containerType="Other" firstNeighbor="MLkuT5b_ikmcYGRo2SAH3w" secondNeighbor="qnwzbs7P1EuiOU6I1AbUmw">
-              <Tags>
-                <Tag value="Neighborhood: LowerJejunum / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="qY_uIgswXECrqHLcIK8Gfg" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="gMtRaJkUM0iQFdCjLYKzwg" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="TtAJshznRkWVyDtwmvn2jA" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="OQs0iUcZnkWbec3GuyVSGQ" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="qPm6Z-NEdkq2e73kCRbGTQ" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="z3GHf_YYo0e65t019oq_mg" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="OKF58T-cY0GKbERZrkrlfA" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Transport id="7kUWrwpGN0STXLxUKxQJ-A" name="DrugAbsorption_para" description="Drug absorption paracellular" mode="Logical" containerType="Transport" dimension="Amount per time" formula="sq1EM757bkyF5h-PABNaKw" sourceAmount="Cuam5DbmZ0uqXwc9apFicg" targetAmount="YgLswliwdkSHukAAVZwL5w">
-                      <Children>
-                        <Parameter id="54OrWySO7UGcUXjfeLHKRg" name="ProcessRate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="mw50aqceKUi0aJwLiv-Aug" visible="0" canBeVaried="1" displayUnit="µmol/min">
-                          <Tags>
-                            <Tag value="DrugAbsorption_para" />
-                            <Tag value="ProcessRate" />
-                            <Tag value="C1" />
-                            <Tag value="Lumen_lje_LowerJejunum_pls" />
-                            <Tag value="Passive" />
-                          </Tags>
-                        </Parameter>
-                      </Children>
-                    </Transport>
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="c-Sg629JPE-5vpcJWLL2JA" name="Lumen_lje_LowerJejunum_cell" description="Neighborhood between Lumen/Lower Jejunum and Mucosa/Lower Jejunum/Intracellular" mode="Logical" containerType="Other" firstNeighbor="MLkuT5b_ikmcYGRo2SAH3w" secondNeighbor="ZS1XYMqua0eBDvqguAeY6g">
-              <Tags>
-                <Tag value="Neighborhood: LowerJejunum / Intracellular" />
-              </Tags>
-              <Children>
-                <Container id="OKlAFzjBkk6dRHcYce6R-g" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="eVHDYPTbn0Gxi0oR258x8A" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="e5VKR7JKZk21U9HJlD7A5A" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="aRMqG8YiJUSfAJZmXrUjOw" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="ezAHDPnckEKYf8L1jOtGfw" visible="0" canBeVaried="0" />
-                    <Parameter id="HoF05HSnoECy6ma0fLW49A" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="bOPO_JT8sEOF6PITZSGGVg" visible="0" canBeVaried="0" />
-                    <Parameter id="kpZ2pWIAREOf26ajpN57Aw" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="aZYSS2yfyEqUEbGBDu38yg" visible="0" canBeVaried="0" />
-                    <Parameter id="KEjvu8K0bU-x5UhB6Rfh9w" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="UIZ0gcOFXUiFj9biQD1zow" visible="0" canBeVaried="0" />
-                    <Parameter id="8TkJgXR0t0OF6aOZRJhQNw" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="GGJAYlTgPkeZx_0cWJIgTg" visible="0" canBeVaried="1" />
-                    <Parameter id="pIi7IQPSjUCwE8mrzBGkCQ" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="-mXfGiMZ6kqYIipaBj_jtA" visible="0" canBeVaried="0" />
-                    <Parameter id="dP1dGtpJPkGPvUmMWmBcoA" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="6gxbxlaZrkGnoa2ICzyhkQ" visible="0" canBeVaried="0" />
-                    <Parameter id="bIa7u7dUbkaoHUfQYOdCLQ" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="lWjfwuEkmkC6QL_K4IgAEg" visible="0" canBeVaried="0" />
-                    <Parameter id="JVDs6Rue4k-93swPV0FsDg" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="0IIh6FJV0UKyrimES0f1xg" visible="0" canBeVaried="0" />
-                    <Parameter id="VjuOi3nsMEiCx07owtH--A" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="KQgllSQtqk2EfhX37WilDQ" visible="0" canBeVaried="0" />
-                    <Parameter id="tur2eyKyHE-EURd-OjBFWQ" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="7NEiCDSKM0i6GhEpoWb-Mw" visible="0" canBeVaried="0" />
-                    <Parameter id="rElBaUiIRk29ylzpW4ofsQ" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="2IVWcgM31UCSVl8zMDnDhw" visible="0" canBeVaried="0" />
-                    <Parameter id="wHq1JClhDUqX1OY_i5T9MA" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="3xvkxp6qK06bn4DgEtYULA" visible="0" canBeVaried="0" />
-                    <Parameter id="45pYIyCodEe9IwXvEM3L3Q" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="Zf9gIX4iaESROWARmz0HTw" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="MX8mes-nkEqu-nL_PfPQJQ" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DNGx_vFWp0KdOb7CGcoTLQ" visible="0" canBeVaried="0" />
-                    <Parameter id="lhtmfttjJkmiX6VtT26acg" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="LcUCvhU3W0udtbpS1KVhEQ" visible="0" canBeVaried="0" />
-                    <Parameter id="iDQcEll9_0KfORluREPVlw" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="H3HPWZTpMkWd61SPEdQpWw" visible="0" canBeVaried="0" />
-                    <Parameter id="ZXM30LeWXEKaUnyd_8trwQ" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="VxA-igQ9skyfsGhm2IVqug" visible="0" canBeVaried="0" />
-                    <Parameter id="VODqInATG02sW74QZKz4bw" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="iYmEEK30bE-ZTPT-N_n7Jg" visible="0" canBeVaried="0" />
-                    <Parameter id="9_88d95ehEaQh719vO7kog" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="PEhoVdLppU-G3xULjX_71g" visible="0" canBeVaried="0" />
-                    <Parameter id="jzbFvK45D0Wm3dUQy1J6kQ" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="pGvG5UNdC0Sot3_d3Qdvag" visible="0" canBeVaried="0" />
-                    <Parameter id="iSuEgjn5DEOqqm8HjQcLbQ" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="jJfeJ2YxEki9TK9XP6uUMA" visible="0" canBeVaried="0" />
-                    <Parameter id="vr2OxzW1CE-XaMzhGUe_eA" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DNF0kWPUFk-rtSd0Ng1Mkw" visible="0" canBeVaried="0" />
-                    <Parameter id="FXy5x5JWkk-NYlPdchhDLw" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="gxoZyuApjEuzsuLtZuZWmQ" visible="0" canBeVaried="0" />
-                    <Parameter id="PAYJ2W5nLEe8wEM1iciwRw" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="qr_x2cq_Y0C6Ur-VSCP4AQ" visible="0" canBeVaried="0" />
-                    <Parameter id="jcqAWMfu1UWxa86q396A2w" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="aWekJ2NVAECIIbxJKJ8L5g" visible="0" canBeVaried="0" />
-                    <Parameter id="n9Vrr-qSF0e-eVGEL6FGdg" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="LG8vT-2Ek02sc2rShJ8d3g" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="Xc-8is5P6Eygsnmw2DfvAg" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Iph7YhQ5KUmsZWUX2Xf2Wg" visible="0" canBeVaried="0" />
-                    <Transport id="U4Kk7jFwdECTnoA9usDopg" name="DrugAbsorption_trans" description="Drug absorption transcellular" mode="Logical" containerType="Transport" dimension="Amount per time" formula="NFRdEG5shk2d-mCeDgrlIg" sourceAmount="Cuam5DbmZ0uqXwc9apFicg" targetAmount="K8vctNgQvkyF2UEwPTSuVQ">
-                      <Children>
-                        <Parameter id="L3QoglqVcU65CM2XTrWKWA" name="ProcessRate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="3CsAk22RCEaxkrAQOfwt2w" visible="0" canBeVaried="1" displayUnit="µmol/min">
-                          <Tags>
-                            <Tag value="DrugAbsorption_trans" />
-                            <Tag value="ProcessRate" />
-                            <Tag value="C1" />
-                            <Tag value="Lumen_lje_LowerJejunum_cell" />
-                            <Tag value="Passive" />
-                          </Tags>
-                        </Parameter>
-                      </Children>
-                    </Transport>
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="clWES9ffs06A2QAZIT1JBQ" name="LowerJejunum_pls_PortalVein_pls" description="Neighborhood between Lower Jejunum/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="qnwzbs7P1EuiOU6I1AbUmw" secondNeighbor="-zX9e5Gif0qLF9-buV_xlA">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="ThZPi3HkT0O_AJ_y8tOESA" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="xi2hhyn4HkGouepHn70uUg" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="4_Nba8MJ-E6AHiiiBrNiEg" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Transport id="ScUg5k6WZUuDEJrAYe1nmA" name="MassTransferMucosaToPvePlasma" description="Mass transfer from Mucosa:Plasma To Portal Vein: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="-6RlIIuRRUeF_WulQ-kNFA" sourceAmount="YgLswliwdkSHukAAVZwL5w" targetAmount="hqBDuJ9j9Eqjy73I0KZSUA" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="I3rD-E4CsUCIKJOvJ7qYsg" name="UpperIleum_pls_PortalVein_pls" description="Neighborhood between Upper Ileum/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="wiKdxf5lkUaXODbbzJ_MgA" secondNeighbor="-zX9e5Gif0qLF9-buV_xlA">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="Q9VM4rwtck2NgkzvtRFA5w" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="hfEs2WmY6UOEMXxoMjxbjg" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="GyZRHXG4KEiJ95SiO3gCdw" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Transport id="RaJFTdwlskeL4ViWdNrtqA" name="MassTransferMucosaToPvePlasma" description="Mass transfer from Mucosa:Plasma To Portal Vein: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="WfFyZVWLQ0ewx6Hu6RWEuQ" sourceAmount="OH4tJOZD_USLmfI7ahxt3w" targetAmount="hqBDuJ9j9Eqjy73I0KZSUA" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="gwv0fANZQU6tWMZn6TFmCA" name="Stomach_pls_Stomach_bc" description="Neighborhood between Stomach/Plasma and Stomach/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="HZ6pfKhao0S84LcP_vvjSQ" secondNeighbor="J3KHzmzoG0ybBAX8Q-IY2w">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="GeQgeX5esEuHCbzZjSJ5iA" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="AnGzWckUdEaSxB8vV6gG0Q" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="MjgW2pg88k2M_xJoKkYM9A" sourceAmount="bgD3avhorEm8i92Um2o6Mw" targetAmount="PyfLvFgK0EK6vo6Wn0xZ1g" />
-                  </Children>
-                </Container>
-                <Parameter id="Q_0VMriYd0OhIDUbjISrmg" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="V94T1ku3YE2zBCMsCHn-7g" visible="1" canBeVaried="1" displayUnit="cm²" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="ptvN1wCP1kmmue80CmwVEA" name="Stomach_pls_Stomach_int" description="Neighborhood between Stomach/Plasma and Stomach/Interstitial" mode="Logical" containerType="Other" firstNeighbor="HZ6pfKhao0S84LcP_vvjSQ" secondNeighbor="T6m82MqYTUWHudDqo8uO-w">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Interstitial" />
-              </Tags>
-              <Children>
-                <Container id="BO631daSYEaIMDtnDswd_Q" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="6RF8s7qdnUuSMDZv1v3Kzg" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Bon9EHArSU6bcCi8KdWj7w" visible="1" canBeVaried="1" />
-                    <Parameter id="-oFKL5R310-hUkkR_8GqCg" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" visible="1" canBeVaried="1" value="10" displayUnit="cm/min" />
-                    <Transport id="NXOds84JrEuNtmPeUeP1mg" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Transport" dimension="Amount per time" formula="t7sIkEpJyECiSxZH-5QVYQ" sourceAmount="bgD3avhorEm8i92Um2o6Mw" targetAmount="Isc12GChREuJ16lL5ZYXXA" />
-                  </Children>
-                </Container>
-                <Parameter id="6e2RUafQ-UyPNQKxZla5xw" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="rvFP9s4JMUmXZcnLgOglRg" visible="1" canBeVaried="1" displayUnit="cm²" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="4hFN6Qg7QUWtk6y6agClTA" name="Stomach_pls_PortalVein_pls" description="Neighborhood between Stomach/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="HZ6pfKhao0S84LcP_vvjSQ" secondNeighbor="-zX9e5Gif0qLF9-buV_xlA">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="ao4Wn1ZuOEu6FZwaP3i3iA" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="nwXNd2rkQUOTQnz_aBYNPw" name="MassTransferOrgPl2BloodPool_pve" description="Mass transfer from organ: Plasma to Portal Vein: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="xb0nS38VW0K0NGGS1IcAig" sourceAmount="bgD3avhorEm8i92Um2o6Mw" targetAmount="hqBDuJ9j9Eqjy73I0KZSUA" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="3M3r6gS3m0mUNlML5gkqAQ" name="Stomach_bc_PortalVein_bc" description="Neighborhood between Stomach/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="J3KHzmzoG0ybBAX8Q-IY2w" secondNeighbor="V3IajphOTUWt3a2j9_LOZA">
-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="1vOzfYXrp0qKbFULh9seIQ" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="xOXiH7yKUEut3rfs88KnjA" name="MassTransferOrgRBC2BloodPool_Pve" description="Mass transfer from organ: Blood Cells to Portal Vein: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="nUZetu67z0yzTCcYT3CHXQ" sourceAmount="PyfLvFgK0EK6vo6Wn0xZ1g" targetAmount="3A4PxVITtUOpr85RBMQZlg" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="qJc-4a_-vkasU7CSMxgIug" name="Stomach_int_Stomach_cell" description="Neighborhood between Stomach/Interstitial and Stomach/Intracellular" mode="Logical" containerType="Other" firstNeighbor="T6m82MqYTUWHudDqo8uO-w" secondNeighbor="AfhvD7y_NUClB-Olz_JKzA">
-              <Tags>
-                <Tag value="Neighborhood: Interstitial / Intracellular" />
-              </Tags>
-              <Children>
-                <Container id="n4pFo4g7RUWXQ-N5HOU-CQ" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="P6EeaJSLr0ieTu7L7JN9Tg" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="BtYHf38KbE2Woag0S8zVQw" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                    <Parameter id="2DxX3fqc6E2J5IiaHjWuWw" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="Y5i-HZk9NUeoA7UKGgQIDg" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                    <Parameter id="1vz2YRO4oEeSkjGMS2coEA" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="hKXq5MVtGkCKHD0_pgT1Kg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="e5M_dL6Qhkaf602n77TOgw" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="p_bsa76dkkG6bsceP87FTg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="6h46HmSSA0ycxMGDuLs_yw" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                    <Parameter id="Gpyntyc5qEK9R__Bb3mHZA" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                    <Parameter id="WrmUaDQ5_UO-YP0C9SJDTQ" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Extj3R_cA0GvjftmyoW9nQ" visible="1" canBeVaried="1" />
-                    <Parameter id="8N-FY7X6sUq2Fk6Gs2Y8Cw" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="X8aa6JXQB0-b6a-LH5_Krw" visible="0" canBeVaried="1" />
-                    <Parameter id="GL7kTm5Fok-gZkaeYHJ0XA" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Vh142ka7RUqyMKoJeL2S8A" visible="0" canBeVaried="0" />
-                    <Transport id="e_EvRTDgbEubwK5wwOPL4A" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Transport" dimension="Amount per time" formula="vCIADRpYg02CHjn42nPZzg" sourceAmount="Isc12GChREuJ16lL5ZYXXA" targetAmount="eyoS1wkcpUqkLrnsBNsX3A" />
-                  </Children>
-                </Container>
-                <Parameter id="fwD4gJ1M9Um9V1MfU9Ko2w" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="YhCvAsTu9U-JH6G0rIWy9A" visible="1" canBeVaried="1" displayUnit="cm²" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="MayYVJSu7kStiC9Hii2iDA" name="Lumen_uil_UpperIleum_cell" description="Neighborhood between Lumen/Upper Ileum and Mucosa/Upper Ileum/Intracellular" mode="Logical" containerType="Other" firstNeighbor="Ybii6aaw1UeIsuUX1COdYA" secondNeighbor="Mn_3bNMJfUilEEDCF8BgJg">
-              <Tags>
-                <Tag value="Neighborhood: UpperIleum / Intracellular" />
-              </Tags>
-              <Children>
-                <Container id="LHvhfzmjPEmFlftnVRfWSw" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="PKMMO6a4jEShp6qX-zv6ZA" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="_4sjUNECnUiBj5KmYH1gDQ" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="d-d6HFjjEU6gGp-4HBJSig" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="uWbirbCcR0G61mvoJ385Ow" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="Pk6gqMGJ5U6lLbKBypKXCw" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="LcUCvhU3W0udtbpS1KVhEQ" visible="0" canBeVaried="0" />
-                    <Parameter id="OP2qUa7LYUKhkd5WzEG9kw" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="aZYSS2yfyEqUEbGBDu38yg" visible="0" canBeVaried="0" />
-                    <Parameter id="7WMQoh36ckGKgpoRqm7iBw" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="OQh7fEoCEUuGah6Zm2hLIA" visible="0" canBeVaried="0" />
-                    <Parameter id="G5vb43G7NkS84rKNo_f-Aw" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CXCSte4ymkyb6-II7VT-3Q" visible="0" canBeVaried="1" />
-                    <Parameter id="L-TB_e7xB06fRlWDhjPdOQ" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="gwtmepUtvk-Pz1m8ha5jMw" visible="0" canBeVaried="0" />
-                    <Parameter id="1bOIk1kAOkOu5X6VQJ8gLw" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IaQYSZMsg0G1acTY5VDIiA" visible="0" canBeVaried="0" />
-                    <Parameter id="0YbRzt8KUEmEIxzX6b4CmA" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="-847g-sa6U2HMDOHFWqrew" visible="0" canBeVaried="0" />
-                    <Parameter id="ILVOE__urUW-HSvIt0Wq6g" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="0IIh6FJV0UKyrimES0f1xg" visible="0" canBeVaried="0" />
-                    <Parameter id="zTk0-FoyQUOqKsp04eBf-A" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="KQgllSQtqk2EfhX37WilDQ" visible="0" canBeVaried="0" />
-                    <Parameter id="GjDY-AJgxEK6AE-TKDGhsQ" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="7NEiCDSKM0i6GhEpoWb-Mw" visible="0" canBeVaried="0" />
-                    <Parameter id="Jm3Tg05_nUWjDgfzDaOm0g" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="3xvkxp6qK06bn4DgEtYULA" visible="0" canBeVaried="0" />
-                    <Parameter id="qk5cYbM9606u6Xw5LmEhyA" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="ezAHDPnckEKYf8L1jOtGfw" visible="0" canBeVaried="0" />
-                    <Parameter id="Qu2zIEo_TUCsFHfyXtmLQw" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DNGx_vFWp0KdOb7CGcoTLQ" visible="0" canBeVaried="0" />
-                    <Parameter id="T5FmW35ly0WIIQDekaNjfg" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="28kNOB9NjEushKneTf6Enw" visible="0" canBeVaried="0" />
-                    <Parameter id="RjskY4ua2UKPt9QSPzlQDQ" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="HMAKJZSsCU27DuQ7um9X2A" visible="0" canBeVaried="0" />
-                    <Parameter id="46MpA022A0GrluVuZOC9dg" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="4ncCXM1VXEuS8vjLrNtA3A" visible="0" canBeVaried="0" />
-                    <Parameter id="vM_6rhF_oUeWe8FnIzR14g" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="PEhoVdLppU-G3xULjX_71g" visible="0" canBeVaried="0" />
-                    <Parameter id="0O8fzjt23EqjQ2xrWKVadg" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="pGvG5UNdC0Sot3_d3Qdvag" visible="0" canBeVaried="0" />
-                    <Parameter id="Mub2jWno20e5ReDxJ8vaBQ" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="jJfeJ2YxEki9TK9XP6uUMA" visible="0" canBeVaried="0" />
-                    <Parameter id="IUdooqeQEkelGc1FLdO2kw" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DNF0kWPUFk-rtSd0Ng1Mkw" visible="0" canBeVaried="0" />
-                    <Parameter id="bEkW3OocLk-WleFA3_GtIg" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="gxoZyuApjEuzsuLtZuZWmQ" visible="0" canBeVaried="0" />
-                    <Parameter id="sSNKwgIIlkqaT7Hno9vNEg" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="qr_x2cq_Y0C6Ur-VSCP4AQ" visible="0" canBeVaried="0" />
-                    <Parameter id="R-2-FeSBr02KBSay52p_4Q" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Iph7YhQ5KUmsZWUX2Xf2Wg" visible="0" canBeVaried="0" />
-                    <Parameter id="iQ9HVhBUa0GthXTLQdJkhw" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="aWekJ2NVAECIIbxJKJ8L5g" visible="0" canBeVaried="0" />
-                    <Parameter id="_X2_o9RNsE-lLaS8Zsopiw" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="2IVWcgM31UCSVl8zMDnDhw" visible="0" canBeVaried="0" />
-                    <Parameter id="t_gPDAHsPkOe7snhonOenQ" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="bOPO_JT8sEOF6PITZSGGVg" visible="0" canBeVaried="0" />
-                    <Parameter id="0JY8yE65UkKc9X9pHDxlyg" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="rb067Seg_U6p_Xq8Mx-1UQ" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Transport id="dthhtrQNy02ngid2p7IzMg" name="DrugAbsorption_trans" description="Drug absorption transcellular" mode="Logical" containerType="Transport" dimension="Amount per time" formula="xN3P_ow3uE6Mh0QqE3mfFg" sourceAmount="xrlOSQNSBk-WGtZ7E-tEYw" targetAmount="27w6YBfNQkyh-7D9Mivddg">
-                      <Children>
-                        <Parameter id="Vmq5yLsvN0WN-tPV-IoNvw" name="ProcessRate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="0DrAGJwZKE2kMvlT31wnmg" visible="0" canBeVaried="1" displayUnit="µmol/min">
-                          <Tags>
-                            <Tag value="DrugAbsorption_trans" />
-                            <Tag value="ProcessRate" />
-                            <Tag value="C1" />
-                            <Tag value="Lumen_uil_UpperIleum_cell" />
-                            <Tag value="Passive" />
-                          </Tags>
-                        </Parameter>
-                      </Children>
-                    </Transport>
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="rtGV0Jqx30ihad-RL3mxPg" name="UpperIleum_bc_PortalVein_bc" description="Neighborhood between Upper Ileum/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="PSVoSQGqZEqHtyvSo86Uug" secondNeighbor="V3IajphOTUWt3a2j9_LOZA">
-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="fGWSdS0O5kO1XAd5wtb62Q" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="ir7RQIcTqkm6bPeIlXp_PQ" name="Mass transfer rate (mucosa to portal vein blood cells)" description="Mass transfer rate (mucosa to portal vein blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="IBM9Cmp92Uyp_WVmnJhJBQ" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Transport id="b59r0rlvHkSi17Xl1Juvxw" name="MassTransferMucosaToPveBC" description="Mass transfer from Mucosa:Blood Cells To Portal Vein: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="hiEIHKbqKkicuHpdsXQOVw" sourceAmount="AmS23HbI_0aVgZpvEhgrww" targetAmount="3A4PxVITtUOpr85RBMQZlg" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="2pq9xBAfek2xfQKEhy40sQ" name="Lumen_uil_UpperIleum_pls" description="Neighborhood between Lumen/Upper Ileum and Mucosa/Upper Ileum/Plasma" mode="Logical" containerType="Other" firstNeighbor="Ybii6aaw1UeIsuUX1COdYA" secondNeighbor="wiKdxf5lkUaXODbbzJ_MgA">
-              <Tags>
-                <Tag value="Neighborhood: UpperIleum / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="svzNWWrrdkeraxA0d5BqpA" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="PcchVNBD3kqiCmsw397hMw" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="WgCWQfCSXU6X-a7JOvmsGA" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="-nLlhetY00GWcWOkFrB08Q" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="tnoo6SeFz0ie_MIfokWwHg" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="ouKkjfWIeUu_LVYoFg_I2g" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="_nGtS8otok6jEHNBkSz9Kg" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Transport id="RVQubQzkXEeCVsLwuJJSHg" name="DrugAbsorption_para" description="Drug absorption paracellular" mode="Logical" containerType="Transport" dimension="Amount per time" formula="4n6-GddPF02Pc3OaqwGJ7g" sourceAmount="xrlOSQNSBk-WGtZ7E-tEYw" targetAmount="OH4tJOZD_USLmfI7ahxt3w">
-                      <Children>
-                        <Parameter id="kZmNEirr8EOB-CV7P7QAAw" name="ProcessRate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="X3l2X93frES1QiGV5hXexw" visible="0" canBeVaried="1" displayUnit="µmol/min">
-                          <Tags>
-                            <Tag value="DrugAbsorption_para" />
-                            <Tag value="ProcessRate" />
-                            <Tag value="C1" />
-                            <Tag value="Lumen_uil_UpperIleum_pls" />
-                            <Tag value="Passive" />
-                          </Tags>
-                        </Parameter>
-                      </Children>
-                    </Transport>
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="QtIjwBiahUWf7ichbynnpg" name="SmallIntestine_bc_LowerJejunum_bc" description="Neighborhood between Small Intestine/Blood Cells_ and Lower Jejunum/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="BO_2kdQ94EefqAdvRA1T2Q" secondNeighbor="kDMQj4cgPkq4YoBI6vj_HA">
-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="uCeRtT1MtUuFr0osY9IWiA" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="0SMyM2wMmkCn1-Vzc8GXxA" name="Mass transfer rate (intestine to mucosa blood cells)" description="Mass transfer rate (intestine to mucosa blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="ptA0QQ34VUGC-OOmWJWxNQ" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Transport id="RrfyhBHlxEakLm22V0_Vhg" name="MassTransferSINToMucosaBC" description="Mass transfer from Small Intestine:Blood Cells to Mucosa: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="LDCD1nle-06Xx--7307xNA" sourceAmount="gACrDjDg5UuEdDtbqzvxDA" targetAmount="6Aqs6_wfI0OKiplexvNuNQ" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="tFQQ21zO40GNNpcKpC0YHg" name="SmallIntestine_pls_LowerJejunum_pls" description="Neighborhood between Small Intestine/Plasma_ and Lower Jejunum/Plasma" mode="Logical" containerType="Other" firstNeighbor="v7QydXWpf0-VYKE0_MwWVQ" secondNeighbor="qnwzbs7P1EuiOU6I1AbUmw">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="kMDwBClHlUyoUqIhVksE_g" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="DvdZ-M0I0EqEAThSy68WqQ" name="Mass transfer rate (intestine to mucosa plasma)" description="Mass transfer rate (intestine to mucosa plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="lRnlnmaKmU-zwzPIZef0XQ" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Transport id="feS-bcmj3U2NPKvaq9LMVg" name="MassTransferSINToMucosaPlasma" description="Mass transfer from Small Intestine:Plasma to Mucosa: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="Fglq1HI_TkuT_obV28dZ3g" sourceAmount="f8G7zu_9zEK_ZkVtpIfeVw" targetAmount="YgLswliwdkSHukAAVZwL5w" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="Jgi8PNoGU0WKJIeNhjKewA" name="SmallIntestine_bc_UpperIleum_bc" description="Neighborhood between Small Intestine/Blood Cells_ and Upper Ileum/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="BO_2kdQ94EefqAdvRA1T2Q" secondNeighbor="PSVoSQGqZEqHtyvSo86Uug">
-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="h6-CfiOwJE2a4HYurBxdkQ" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="GZbw-ZakGkmZIS9Z5zszTQ" name="Mass transfer rate (intestine to mucosa blood cells)" description="Mass transfer rate (intestine to mucosa blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="Kgz7pU0kBUaoZOKpvCEPKA" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Transport id="dUrJU0XBMkq-GU5UB825UQ" name="MassTransferSINToMucosaBC" description="Mass transfer from Small Intestine:Blood Cells to Mucosa: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="avdZP6lfnE6b-sQ1SHBFAw" sourceAmount="gACrDjDg5UuEdDtbqzvxDA" targetAmount="AmS23HbI_0aVgZpvEhgrww" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="wP2-yYDsEUGNXo65W02KKg" name="SmallIntestine_bc_UpperJejunum_bc" description="Neighborhood between Small Intestine/Blood Cells_ and Upper Jejunum/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="BO_2kdQ94EefqAdvRA1T2Q" secondNeighbor="BiBid5i4Sk2EK94scFpeHw">
-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="tyxbHEFVeECGNMHb8goX7Q" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="ji9PYrzJukuBFdWgoO-COw" name="Mass transfer rate (intestine to mucosa blood cells)" description="Mass transfer rate (intestine to mucosa blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="dmIJ2c4h9kOemKrjJE9zFw" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Transport id="HuN-1FEr5ku_mu3kcJ-z7w" name="MassTransferSINToMucosaBC" description="Mass transfer from Small Intestine:Blood Cells to Mucosa: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="fU-VEUqj8UuH4DO0agpjnQ" sourceAmount="gACrDjDg5UuEdDtbqzvxDA" targetAmount="RgAh2V1O4EKEVX6UAhe4zQ" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="CaLPuOLMSE2qY5WMNTy2dA" name="SmallIntestine_pls_UpperJejunum_pls" description="Neighborhood between Small Intestine/Plasma_ and Upper Jejunum/Plasma" mode="Logical" containerType="Other" firstNeighbor="v7QydXWpf0-VYKE0_MwWVQ" secondNeighbor="Mqff24qDg0q3J5knCoXTZw">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="uPFAOfvO20OjE8HzT44D6A" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="u53uURKDeEivzHM_BdqDMg" name="Mass transfer rate (intestine to mucosa plasma)" description="Mass transfer rate (intestine to mucosa plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="nAMRbkvlL0umGB77Wp7CrQ" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Transport id="xm2V-92ZVU6RIbxja7G7Kg" name="MassTransferSINToMucosaPlasma" description="Mass transfer from Small Intestine:Plasma to Mucosa: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="w96jflKD80WgwLzH6USUIQ" sourceAmount="f8G7zu_9zEK_ZkVtpIfeVw" targetAmount="PMNegnlhr0CXVnvfwhXU7g" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="aP0iAYiGS0Wi--LDtl9IeQ" name="SmallIntestine_bc_Duodenum_bc" description="Neighborhood between Small Intestine/Blood Cells_ and Duodenum/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="BO_2kdQ94EefqAdvRA1T2Q" secondNeighbor="TdV1_un1aESakxFEr6GkQw">
-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="Tz_meUw0NEGXMlt155IShA" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="gvOnq7oi8EGDHV4l_saXYw" name="Mass transfer rate (intestine to mucosa blood cells)" description="Mass transfer rate (intestine to mucosa blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="4feUEzURQE-toxYNBqWajw" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Transport id="BtNhElmbPEuDb-sEU2_3kA" name="MassTransferSINToMucosaBC" description="Mass transfer from Small Intestine:Blood Cells to Mucosa: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="iJ7vqHHIp06Q_CS6F-CUjw" sourceAmount="gACrDjDg5UuEdDtbqzvxDA" targetAmount="F5meuBt0ck6H-U7fLJ-DUg" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="71UVVQJtlE-4QrM-qUYsFw" name="SmallIntestine_pls_Duodenum_pls" description="Neighborhood between Small Intestine/Plasma_ and Duodenum/Plasma" mode="Logical" containerType="Other" firstNeighbor="v7QydXWpf0-VYKE0_MwWVQ" secondNeighbor="5qa_dNfzPEqENSftAboAkA">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="iyrWpS44u0atLcFnqfxTnw" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="Q_h55imW80qnudR3Awnb-Q" name="Mass transfer rate (intestine to mucosa plasma)" description="Mass transfer rate (intestine to mucosa plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="x16INAER3kGyaKaBWPZ3tw" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Transport id="LKmr51zaOkKc2gOk0lT4Tw" name="MassTransferSINToMucosaPlasma" description="Mass transfer from Small Intestine:Plasma to Mucosa: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="QT8CjBIzbEij_1L_VHUG6w" sourceAmount="f8G7zu_9zEK_ZkVtpIfeVw" targetAmount="9U0qncgJp0GzhMN51sFuvg" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="4JKBb1pg9EKbJzYIrGB7IQ" name="SmallIntestine_pls_UpperIleum_pls" description="Neighborhood between Small Intestine/Plasma_ and Upper Ileum/Plasma" mode="Logical" containerType="Other" firstNeighbor="v7QydXWpf0-VYKE0_MwWVQ" secondNeighbor="wiKdxf5lkUaXODbbzJ_MgA">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="jeEP_yiNlkCv3gTxs1WxIQ" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="N6h3icP3OkqnLMZvedNIPg" name="Mass transfer rate (intestine to mucosa plasma)" description="Mass transfer rate (intestine to mucosa plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="HRPREU-OG0aYOVfI0qZqkg" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Transport id="d8z8SvQlbk2K4stRZZdERw" name="MassTransferSINToMucosaPlasma" description="Mass transfer from Small Intestine:Plasma to Mucosa: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="YnNfy-kj7kq-8-V1ntFVMw" sourceAmount="f8G7zu_9zEK_ZkVtpIfeVw" targetAmount="OH4tJOZD_USLmfI7ahxt3w" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="z3hrT9Lf50KF-DbEF1AMSQ" name="LowerIleum_bc_PortalVein_bc" description="Neighborhood between Lower Ileum/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="NNtCjKsDKEmpfBZtoykFkw" secondNeighbor="V3IajphOTUWt3a2j9_LOZA">
-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="m-XxHFUgdkSJ_3b3QKSAvQ" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="tCKLkvErFk2BJMY_0L72zw" name="Mass transfer rate (mucosa to portal vein blood cells)" description="Mass transfer rate (mucosa to portal vein blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="GuLJp58VbU2RY9pGxlkIzA" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Transport id="JYf0711SDUiIypmf_xKdDw" name="MassTransferMucosaToPveBC" description="Mass transfer from Mucosa:Blood Cells To Portal Vein: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="riRhHks1Wki8WOZHnmOTpQ" sourceAmount="o1HQX8-RRUmWuRf1rvmfuA" targetAmount="3A4PxVITtUOpr85RBMQZlg" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="xxZT42xqKUev9XV1XXhw4w" name="LowerIleum_pls_PortalVein_pls" description="Neighborhood between Lower Ileum/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="rrdHQQGA002quyiJj14SNw" secondNeighbor="-zX9e5Gif0qLF9-buV_xlA">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="D7CUPI2zkkSymAuZ0cBLYg" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="ORxWCz-5XE2HtHFVE7kyLg" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="AnYjeRDBK02LCMCVXtouAg" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Transport id="2i5Xyv3fXU-AByNwy9giBA" name="MassTransferMucosaToPvePlasma" description="Mass transfer from Mucosa:Plasma To Portal Vein: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="S1yRX0JwDUCtWkNzhEXFJg" sourceAmount="0cutZov5eEiqqp_uiBzdtw" targetAmount="hqBDuJ9j9Eqjy73I0KZSUA" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="X-_N7GbiPUWBXt0OW47gVw" name="SmallIntestine_bc_LowerIleum_bc" description="Neighborhood between Small Intestine/Blood Cells_ and Lower Ileum/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="BO_2kdQ94EefqAdvRA1T2Q" secondNeighbor="NNtCjKsDKEmpfBZtoykFkw">
-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="VQJeq5mpdUO_YqVFkruvTQ" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="uXdTzW0_30GvXb-y0OUVxg" name="Mass transfer rate (intestine to mucosa blood cells)" description="Mass transfer rate (intestine to mucosa blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="ri_HmQNAp0uuuNjwDIFEXw" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Transport id="Fn5ebeX9rkOCiqNjs6H7DQ" name="MassTransferSINToMucosaBC" description="Mass transfer from Small Intestine:Blood Cells to Mucosa: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="-I2bD11MPkyX1buVWa8Ztg" sourceAmount="gACrDjDg5UuEdDtbqzvxDA" targetAmount="o1HQX8-RRUmWuRf1rvmfuA" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="pK0CQaahp0W1tm9t4cr7kQ" name="SmallIntestine_pls_LowerIleum_pls" description="Neighborhood between Small Intestine/Plasma_ and Lower Ileum/Plasma" mode="Logical" containerType="Other" firstNeighbor="v7QydXWpf0-VYKE0_MwWVQ" secondNeighbor="rrdHQQGA002quyiJj14SNw">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="okn5sd3YtEaiKID8nzJhog" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="ESTGJtkTgU28OpAMy2seVg" name="Mass transfer rate (intestine to mucosa plasma)" description="Mass transfer rate (intestine to mucosa plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="to7IsKyUTk6fTmGjVGBl0Q" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Transport id="YDyPnw_BaEq5MwicgtPPFw" name="MassTransferSINToMucosaPlasma" description="Mass transfer from Small Intestine:Plasma to Mucosa: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="1SIYnEGAIU6QRG0t9Cn1VQ" sourceAmount="f8G7zu_9zEK_ZkVtpIfeVw" targetAmount="0cutZov5eEiqqp_uiBzdtw" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="Hw6F-s0NPUiVigabbpYeOA" name="Lumen_lil_LowerIleum_cell" description="Neighborhood between Lumen/Lower Ileum and Mucosa/Lower Ileum/Intracellular" mode="Logical" containerType="Other" firstNeighbor="igIrhkz7s0ehw7sHmKiBCg" secondNeighbor="sI2lB80kS0qpJ8_ruusBLA">
-              <Tags>
-                <Tag value="Neighborhood: LowerIleum / Intracellular" />
-              </Tags>
-              <Children>
-                <Container id="p1rMaqu2EUGm4nIdPu-qvA" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="wwgYUqyxzk2JCXA1H4ue1Q" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="6yvyCekFy02AoCb1KS0bNg" visible="0" canBeVaried="0" />
-                    <Parameter id="e_ey_3qtMke8XydDFQynmA" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="7bufxjr5EE6MKHH6bTNJVg" visible="0" canBeVaried="0" />
-                    <Parameter id="2R-yJfdl00mkIc7xCUoX6g" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="PEhoVdLppU-G3xULjX_71g" visible="0" canBeVaried="0" />
-                    <Parameter id="0eyrpUiemUGKsqDNsKjQrg" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="pGvG5UNdC0Sot3_d3Qdvag" visible="0" canBeVaried="0" />
-                    <Parameter id="HLkWJ9wzxkm3rJdBpjVt0g" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="jJfeJ2YxEki9TK9XP6uUMA" visible="0" canBeVaried="0" />
-                    <Parameter id="fr8v30kLBUaJfm9010shxQ" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DNF0kWPUFk-rtSd0Ng1Mkw" visible="0" canBeVaried="0" />
-                    <Parameter id="qunvExK3FUamhk_vmH_kCQ" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="gxoZyuApjEuzsuLtZuZWmQ" visible="0" canBeVaried="0" />
-                    <Parameter id="PjJqfPQXdkeWQEkbozMmaA" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="qr_x2cq_Y0C6Ur-VSCP4AQ" visible="0" canBeVaried="0" />
-                    <Parameter id="eZQ8EF1_4EmRYG6ebkeJog" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Iph7YhQ5KUmsZWUX2Xf2Wg" visible="0" canBeVaried="0" />
-                    <Parameter id="kAUCxoxzn0ilzRmcWySLFw" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="aWekJ2NVAECIIbxJKJ8L5g" visible="0" canBeVaried="0" />
-                    <Parameter id="wr_R161pd0qk5ifmkK07Jg" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="A0aQLJr2u0KYdAl8yqWuhQ" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="vyh46hMUmEOhAjoudPx8kA" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DNGx_vFWp0KdOb7CGcoTLQ" visible="0" canBeVaried="0" />
-                    <Parameter id="mRTGHmMEAUq4JNRGH6e40Q" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="fxt9xx8-IkaoWUebIvr9xw" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="pk6p687ZpE-eltvFYnvt4w" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="aZYSS2yfyEqUEbGBDu38yg" visible="0" canBeVaried="0" />
-                    <Parameter id="dtm9iY75zESnjE3MBaaUcw" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="c3Aogzme0EybAaIYpcxFRg" visible="0" canBeVaried="0" />
-                    <Parameter id="82PgXufq3Um5H0caX6G7uw" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="bOPO_JT8sEOF6PITZSGGVg" visible="0" canBeVaried="0" />
-                    <Parameter id="KJ1ZMSov2ECDtweFWyVDiA" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="LcUCvhU3W0udtbpS1KVhEQ" visible="0" canBeVaried="0" />
-                    <Parameter id="EhXcha1dDkOOwAD1U2uciw" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="PC0-TBuXhE2pjXu4jlfXrg" visible="0" canBeVaried="0" />
-                    <Parameter id="e9hGsO8nBkeaTEThRAJwCA" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="H8USh-gL7U2EdilSgltpGA" visible="0" canBeVaried="1" />
-                    <Parameter id="rX4NWpE_HUGZ-5cUYaAiog" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="xiu_aoVcGE-9JeD7_mV-Kg" visible="0" canBeVaried="0" />
-                    <Parameter id="i8A2vbVLT0GeYaUGnCKq_w" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="LissaqOMkEK06YDfKnQX_A" visible="0" canBeVaried="0" />
-                    <Parameter id="c42mmCsj1ky7XXb7P0KSOw" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="535_NipLs0qp_ynyEh4LIg" visible="0" canBeVaried="0" />
-                    <Parameter id="2SwN8cS6c0SS7t7O0EnQlw" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="0IIh6FJV0UKyrimES0f1xg" visible="0" canBeVaried="0" />
-                    <Parameter id="HlNk3GLlxkCGVX0aLezOtw" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="KQgllSQtqk2EfhX37WilDQ" visible="0" canBeVaried="0" />
-                    <Parameter id="LP_ONyqJdkCSU8PtYO95cQ" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="7NEiCDSKM0i6GhEpoWb-Mw" visible="0" canBeVaried="0" />
-                    <Parameter id="S5VO6DF8cU2tHxvpn9l-Lw" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="3xvkxp6qK06bn4DgEtYULA" visible="0" canBeVaried="0" />
-                    <Parameter id="6bA8A0pzPkuGAfu6AGoL7g" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="ezAHDPnckEKYf8L1jOtGfw" visible="0" canBeVaried="0" />
-                    <Parameter id="eNH_svdzek-fiDDyWaeIdQ" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="2IVWcgM31UCSVl8zMDnDhw" visible="0" canBeVaried="0" />
-                    <Parameter id="HzmVU99QjES5CQrBY9OHUA" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="ig03653Uq0mqU7VB97iodA" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Transport id="ODrE40_ABkSj6vfmwQeoEw" name="DrugAbsorption_trans" description="Drug absorption transcellular" mode="Logical" containerType="Transport" dimension="Amount per time" formula="ta2k6vnbSEWLMaKZF5zw_g" sourceAmount="yw7rzbgJB0-l91_K8hz0sQ" targetAmount="2dcifeUtpkujhqGqlE3Qnw">
-                      <Children>
-                        <Parameter id="obRSMCGE3UCHEG7EXZJxog" name="ProcessRate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="kssVugh9FkGjcfPwnlTRRg" visible="0" canBeVaried="1" displayUnit="µmol/min">
-                          <Tags>
-                            <Tag value="DrugAbsorption_trans" />
-                            <Tag value="ProcessRate" />
-                            <Tag value="C1" />
-                            <Tag value="Lumen_lil_LowerIleum_cell" />
-                            <Tag value="Passive" />
-                          </Tags>
-                        </Parameter>
-                      </Children>
-                    </Transport>
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="1YO-OaT3fk6gl2niNlRdhg" name="Lumen_lil_LowerIleum_pls" description="Neighborhood between Lumen/Lower Ileum and Mucosa/Lower Ileum/Plasma" mode="Logical" containerType="Other" firstNeighbor="igIrhkz7s0ehw7sHmKiBCg" secondNeighbor="rrdHQQGA002quyiJj14SNw">
-              <Tags>
-                <Tag value="Neighborhood: LowerIleum / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="rMdJ24x7dk273D5cGaLhLA" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="LnKNq8wFoU2O79fzmg50Wg" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="xj_Y24-PJECv7YHTavI5Ig" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="gGOY8G_ILk69meL6Lpjq3g" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="IZiQhxuVi0SK2DlgOu8Nfw" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="ukWFn2EkvEikILWwFhfzCQ" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="lNtv9aqONkOsQB0JKc_1TQ" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Transport id="GviVQxrwZkCHxbU4pVRiqw" name="DrugAbsorption_para" description="Drug absorption paracellular" mode="Logical" containerType="Transport" dimension="Amount per time" formula="PjB0uQ9mEkGOh9kL03EJ3A" sourceAmount="yw7rzbgJB0-l91_K8hz0sQ" targetAmount="0cutZov5eEiqqp_uiBzdtw">
-                      <Children>
-                        <Parameter id="mTDGLhWG8kWK3x7Mu--hng" name="ProcessRate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="ll4JNT9-6kOrJf8QXfqM9Q" visible="0" canBeVaried="1" displayUnit="µmol/min">
-                          <Tags>
-                            <Tag value="DrugAbsorption_para" />
-                            <Tag value="ProcessRate" />
-                            <Tag value="C1" />
-                            <Tag value="Lumen_lil_LowerIleum_pls" />
-                            <Tag value="Passive" />
-                          </Tags>
-                        </Parameter>
-                      </Children>
-                    </Transport>
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="ojFIxqKn5E-oMGUDzdGBnA" name="SmallIntestine_int_SmallIntestine_cell" description="Neighborhood between Small Intestine/Interstitial and Small Intestine/Intracellular" mode="Logical" containerType="Other" firstNeighbor="ilLnP1DOPkuzNEpG7Fv3Lg" secondNeighbor="OHqsp3isJUGXVMaVk0iHQg">
-              <Tags>
-                <Tag value="Neighborhood: Interstitial / Intracellular" />
-                <Tag value="Small intestine  neighborhood" />
-              </Tags>
-              <Children>
-                <Container id="nXX62em9zEqkPIf1I8S-iQ" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="oQz19CjiWES9-qWyqX_PNQ" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="BtYHf38KbE2Woag0S8zVQw" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                    <Parameter id="z7k9zSkt7kWPPctb17_ZTg" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="Y5i-HZk9NUeoA7UKGgQIDg" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                    <Parameter id="kj_A0HCHNEykiZZHEIIR8A" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="hKXq5MVtGkCKHD0_pgT1Kg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="fprSINi3d0e0MmyyXxl-uw" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="p_bsa76dkkG6bsceP87FTg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="VT8CVkMxwk-dWHdAsde3Zw" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                    <Parameter id="Y77Bki6B70SaM0XqmEc2jw" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                    <Parameter id="OrPVrVWxQkaJ1sq9pyw54Q" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="v-1sIkNZfUC3FjD2xOQCfQ" visible="1" canBeVaried="1" />
-                    <Parameter id="Wy28xRz12EOdyU_HIC2BOA" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="X8aa6JXQB0-b6a-LH5_Krw" visible="0" canBeVaried="1" />
-                    <Parameter id="zXiSFJZto0WHfqIzMdfOKQ" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="lu4zUH9xWUeBUaDg04lGug" visible="0" canBeVaried="0" />
-                    <Transport id="2gtb4VHK6kqQ-u9n0iOkvA" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Transport" dimension="Amount per time" formula="pSEvqbUT9UyQKq7XT9qRXg" sourceAmount="fclzk6VWh02b904j5Lzyow" targetAmount="HO6kTUalu0Wh1XgMk3T-Vg" />
-                  </Children>
-                </Container>
-                <Parameter id="KZmPtRq6_0mGOJkJn5QP0A" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="QtNnwiUTmk-Np7TPdoaKgg" visible="1" canBeVaried="1" displayUnit="cm²" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="mor0olxPOEmkcIJ9X6JskA" name="SmallIntestine_pls_SmallIntestine_int" description="Neighborhood between Small Intestine/Plasma and Small Intestine/Interstitial" mode="Logical" containerType="Other" firstNeighbor="v7QydXWpf0-VYKE0_MwWVQ" secondNeighbor="ilLnP1DOPkuzNEpG7Fv3Lg">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Interstitial" />
-                <Tag value="Small intestine  neighborhood" />
-              </Tags>
-              <Children>
-                <Container id="m1uTViv4gkSRKzWkjw9xhA" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="pQx3IM8gsEi6QBprhP91gA" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Bon9EHArSU6bcCi8KdWj7w" visible="1" canBeVaried="1" />
-                    <Parameter id="nuSSNraCOk-ffF0SFyenjQ" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" visible="1" canBeVaried="1" value="10" displayUnit="cm/min" />
-                    <Transport id="P3rDVoHsMkqxW7kdfwaL0w" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Transport" dimension="Amount per time" formula="PjpOflMrKEaPOTSK--8P2A" sourceAmount="f8G7zu_9zEK_ZkVtpIfeVw" targetAmount="fclzk6VWh02b904j5Lzyow" />
-                  </Children>
-                </Container>
-                <Parameter id="lgOeiYG86EuzBRWGhAI7vg" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="dFogA47WSESKRhUF1p4IOQ" visible="1" canBeVaried="1" displayUnit="cm²" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="gJtZTXKatUmDuypmruIpqw" name="SmallIntestine_pls_SmallIntestine_bc" description="Neighborhood between Small Intestine/Plasma and Small Intestine/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="v7QydXWpf0-VYKE0_MwWVQ" secondNeighbor="BO_2kdQ94EefqAdvRA1T2Q">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / BloodCells" />
-                <Tag value="Small intestine  neighborhood" />
-              </Tags>
-              <Children>
-                <Container id="u9plvh2X6U6XAVYR1MivGw" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="rQd5MiqTb0CcjzDt-zJW6A" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="Vl_x-4jt9kabiX4Bw3oMEw" sourceAmount="f8G7zu_9zEK_ZkVtpIfeVw" targetAmount="gACrDjDg5UuEdDtbqzvxDA" />
-                  </Children>
-                </Container>
-                <Parameter id="Rjlzhx3JtEecBd1FLoFhVg" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="sZqHki5_PUeVDCO3BU08dw" visible="1" canBeVaried="1" displayUnit="cm²" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="6aMpTJu8C0Sn0sFZysPfEQ" name="SmallIntestine_pls_PortalVein_pls" description="Neighborhood between Small Intestine/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="v7QydXWpf0-VYKE0_MwWVQ" secondNeighbor="-zX9e5Gif0qLF9-buV_xlA">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="mpWvkUq4pUOAy1jUvFvXaA" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="R1HTMuwE0Uq32K2HvKv6HA" name="MassTransferSinPlasma2BloodPool_Pve" description="Mass transfer from Small Intestine:Plasma to Portal Vein: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="9-JifV5_wUmE9niDo6bIIQ" sourceAmount="f8G7zu_9zEK_ZkVtpIfeVw" targetAmount="hqBDuJ9j9Eqjy73I0KZSUA" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="fntZLUBYQkKSmYrLz-YxWQ" name="SmallIntestine_bc_PortalVein_bc" description="Neighborhood between Small Intestine/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="BO_2kdQ94EefqAdvRA1T2Q" secondNeighbor="V3IajphOTUWt3a2j9_LOZA">
-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="YOKt8IsWi0qyTxkNdtYfNg" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="Lw2C4DPmLk-ZOnB3cUWLjg" name="MassTransferSinRBC2BloodPool_Pve" description="Mass transfer from Small Intestine:Blood Cells to Portal Vein: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="4-cg3mAlGkqJItow_SlCuw" sourceAmount="gACrDjDg5UuEdDtbqzvxDA" targetAmount="3A4PxVITtUOpr85RBMQZlg" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="u8aLQ2rXxUSeJ5J1_p8UNg" name="LargeIntestine_bc_PortalVein_bc" description="Neighborhood between Large Intestine/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="SXH64aI-W0uPsXU5nSDPlA" secondNeighbor="V3IajphOTUWt3a2j9_LOZA">
-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
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-              <Children>
-                <Container id="i7zFIWaKZ0qtaVjp_6JFAA" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="JZukBRGx40GQFtPeFm9GRw" name="MassTransferLinRBC2BloodPool_Pve" description="Mass transfer from Large Intestine to Portal Vein: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="tbMSKAkkw0aY4PSX1mWAsw" sourceAmount="1CoHmlwfmEyD48lxr-SSNg" targetAmount="3A4PxVITtUOpr85RBMQZlg" />
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-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
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-              <Children>
-                <Container id="LYKGDH9y_0mt2SxJF8ZKlA" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="aFYPSVQOS0S-t67qVdPgqg" name="Mass transfer rate (intestine to mucosa blood cells)" description="Mass transfer rate (intestine to mucosa blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="j_jOiaMy_Uio2qnHNnw-DA" visible="0" canBeVaried="0" displayUnit="µmol/min" />
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-            <Neighborhood id="XLYV_hHZlUWxPumuTKtL-w" name="LargeIntestine_pls_Rectum_pls" description="Neighborhood between Large Intestine/Plasma_ and Rectum/Plasma" mode="Logical" containerType="Other" firstNeighbor="uvQs1PS9aUqsBpd5BT5HkA" secondNeighbor="WMIBikKwrEe1vMFMiv-ong">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
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-              <Children>
-                <Container id="Va0AJx4AZkCU_BAC96h3FQ" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="9HgbeJZIsUaQGmc9_ze-Fw" name="Mass transfer rate (intestine to mucosa plasma)" description="Mass transfer rate (intestine to mucosa plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="lwky6E87WEy3zUzIo_e0Wg" visible="0" canBeVaried="0" displayUnit="µmol/min" />
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-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
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-              <Children>
-                <Container id="4BqbZEbJrkmwoksjUYkZ5w" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="Gt3E4KboK0SHUTtnboc1hA" name="Mass transfer rate (intestine to mucosa blood cells)" description="Mass transfer rate (intestine to mucosa blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="3AwjB37suEaHd46cOmSCZg" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Transport id="q4Us0bV1v0qB80HbhKuOcg" name="MassTransferLINToMucosaBC" description="Mass transfer from Large Intestine:Blood Cells to Mucosa: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="wq5cwrdSj0u1X59-5DzAWw" sourceAmount="1CoHmlwfmEyD48lxr-SSNg" targetAmount="nPc7HZ7onEeWVXA5yaAQVg" />
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-            <Neighborhood id="OdEwekeJTU681ANmR1zEwg" name="LargeIntestine_pls_ColonSigmoid_pls" description="Neighborhood between Large Intestine/Plasma_ and Colon Sigmoid/Plasma" mode="Logical" containerType="Other" firstNeighbor="uvQs1PS9aUqsBpd5BT5HkA" secondNeighbor="bzYLFyk2JkmtP6F5xOz6QQ">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
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-              <Children>
-                <Container id="DzOvGfyEAUKo-7jPujOKgw" name="C1" mode="Logical" containerType="Molecule">
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-                    <Parameter id="JBs_PUOfcUGSnvoeehR3Dw" name="Mass transfer rate (intestine to mucosa plasma)" description="Mass transfer rate (intestine to mucosa plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="eIiLyxWIO0qlj9Q6jugVaA" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Transport id="8VWZ2J2090O4pBZvKhLxSA" name="MassTransferLINToMucosaPlasma" description="Mass transfer from Large Intestine:Plasma to Mucosa: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="ETPOkSZAsU6MAMA5vVKo7g" sourceAmount="xpcrmRU34EqRDnqQj6ZOeA" targetAmount="xTGJR_rEKE6vG1pK_dnKhA" />
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-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
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-              <Children>
-                <Container id="lNrZeGsKIk2gjDz05WCnKw" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="lHh-UYmSr0WkqwzAjAiuoQ" name="Mass transfer rate (intestine to mucosa blood cells)" description="Mass transfer rate (intestine to mucosa blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="cxN41IuZIkKenGapZjnLvA" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Transport id="b3CG2w7trEuUwC0nne3gfQ" name="MassTransferLINToMucosaBC" description="Mass transfer from Large Intestine:Blood Cells to Mucosa: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="snRT01zJ-0C6stVd8X-E9g" sourceAmount="1CoHmlwfmEyD48lxr-SSNg" targetAmount="3eMVtSbfykKuZmsiS31jUg" />
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-            <Neighborhood id="WOiv1jKyhkC8EZZ4jKXRqQ" name="LargeIntestine_pls_ColonDescendens_pls" description="Neighborhood between Large Intestine/Plasma_ and Colon Descendens/Plasma" mode="Logical" containerType="Other" firstNeighbor="uvQs1PS9aUqsBpd5BT5HkA" secondNeighbor="IYSOBD2MW0SByEccir1gtg">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
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-              <Children>
-                <Container id="ZrxeJ1Iff0Wf6DwjV4MdIw" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="gULLBrTfskqyo36G8zHRqw" name="Mass transfer rate (intestine to mucosa plasma)" description="Mass transfer rate (intestine to mucosa plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="pddfpZDG0EiJJRNstRbimQ" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Transport id="Ez59b4czl0CAw_kA65jmXQ" name="MassTransferLINToMucosaPlasma" description="Mass transfer from Large Intestine:Plasma to Mucosa: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="ttE0oBM-U0OY6rO3aVOMYg" sourceAmount="xpcrmRU34EqRDnqQj6ZOeA" targetAmount="fRScY5akTkSbcR1hbKcs5Q" />
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-            <Neighborhood id="wcxARq9v3Uyx7tcgkj9Jkw" name="LargeIntestine_bc_ColonTransversum_bc" description="Neighborhood between Large Intestine/Blood Cells_ and Colon Transversum/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="SXH64aI-W0uPsXU5nSDPlA" secondNeighbor="nK4V9tiRUUy-zjLhRo56OA">
-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
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-              <Children>
-                <Container id="jNX4xNnuDEWz278tfNlEqA" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="v4xaV0RiQ0yeH-tacG_ndQ" name="Mass transfer rate (intestine to mucosa blood cells)" description="Mass transfer rate (intestine to mucosa blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="-9JS7E9W90mSmwgWg77vug" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Transport id="7OHGYGCQ5kakopXKtV3JwQ" name="MassTransferLINToMucosaBC" description="Mass transfer from Large Intestine:Blood Cells to Mucosa: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="SZ7wOz0DI0WTDgFKQRZArA" sourceAmount="1CoHmlwfmEyD48lxr-SSNg" targetAmount="2BQp7lKGjkCgjUSXvOs6QQ" />
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-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
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-              <Children>
-                <Container id="IATX9DZ75U6on67oombIWg" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="h-0tnjWVJk2I1dTDiNmazg" name="Mass transfer rate (intestine to mucosa blood cells)" description="Mass transfer rate (intestine to mucosa blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="ac15oklOqkaYhtrTebA_jg" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Transport id="n_6rAnRaikO1kn36sfHc7Q" name="MassTransferLINToMucosaBC" description="Mass transfer from Large Intestine:Blood Cells to Mucosa: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="eLQGdOkskEysEa-ZdOpu0Q" sourceAmount="1CoHmlwfmEyD48lxr-SSNg" targetAmount="05yORl8O3EeGbBTdKhAhHA" />
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-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
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-              <Children>
-                <Container id="INMHuIYI4Uyp1phMNemzkw" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="4b0EZxlTj0K7-GxxtAQ-Jw" name="Mass transfer rate (intestine to mucosa plasma)" description="Mass transfer rate (intestine to mucosa plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="fyTABT0ry0CSKslXfuvBxw" visible="0" canBeVaried="0" displayUnit="µmol/min" />
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-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
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-              <Children>
-                <Container id="G3ea_k0hek2ceybNy_rrSQ" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="Pp5sSc6A3kevFLd3yzWpGA" name="Mass transfer rate (intestine to mucosa blood cells)" description="Mass transfer rate (intestine to mucosa blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="Xwv2hnSHAUKofFp7fi1dsg" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Transport id="y6jFrBjoKk-iXUKhYbSRkA" name="MassTransferLINToMucosaBC" description="Mass transfer from Large Intestine:Blood Cells to Mucosa: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="x6VaEw44kEGJ_4awYPPNIQ" sourceAmount="1CoHmlwfmEyD48lxr-SSNg" targetAmount="Ls0R4hvRKki76eHKnnDq6g" />
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-            <Neighborhood id="nT7YO3XKokOQ83jWkAid0g" name="LargeIntestine_pls_ColonAscendens_pls" description="Neighborhood between Large Intestine/Plasma_ and Colon Ascendens/Plasma" mode="Logical" containerType="Other" firstNeighbor="uvQs1PS9aUqsBpd5BT5HkA" secondNeighbor="Aivr7qttHUatCWB0Vus_ew">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
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-              <Children>
-                <Container id="yorU7v7GnEO84GnE2oS67w" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="T7k9o93l10-2Vj4IOCCXZQ" name="Mass transfer rate (intestine to mucosa plasma)" description="Mass transfer rate (intestine to mucosa plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="gNUU_sbtp0Gy1vhDetrK1w" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Transport id="JTQhDrC-20WrbwpdzW-Ndg" name="MassTransferLINToMucosaPlasma" description="Mass transfer from Large Intestine:Plasma to Mucosa: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="Zhj-MWxMs0uysvZ1JlaRBw" sourceAmount="xpcrmRU34EqRDnqQj6ZOeA" targetAmount="0zNjwXhGpkSaSYQZC4yzdw" />
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-            <Neighborhood id="fnGvSTFVHUSLx0I0DL-vFw" name="LargeIntestine_pls_LargeIntestine_bc" description="Neighborhood between Large Intestine/Plasma and Large Intestine/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="uvQs1PS9aUqsBpd5BT5HkA" secondNeighbor="SXH64aI-W0uPsXU5nSDPlA">
-              <Tags>
-                <Tag value="Large intestine  neighborhood" />
-                <Tag value="Neighborhood: Plasma / BloodCells" />
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-              <Children>
-                <Container id="mIGs3ppzP02DOoS1MAljxg" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="TC1ApgqT1UC3TFSrn_Hk_A" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="tR9dwnJSk0isR00TYQn5lA" sourceAmount="xpcrmRU34EqRDnqQj6ZOeA" targetAmount="1CoHmlwfmEyD48lxr-SSNg" />
-                  </Children>
-                </Container>
-                <Parameter id="kVfADRaN0EGpMCeEFZIvmQ" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="LED1mrNSIk-_5q1AyNmQ1A" visible="1" canBeVaried="1" displayUnit="cm²" />
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-              <Tags>
-                <Tag value="Large intestine  neighborhood" />
-                <Tag value="Neighborhood: Interstitial / Intracellular" />
-              </Tags>
-              <Children>
-                <Container id="j7cgStaaL0Ou-a9kgu8VzA" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="3hGkl0UdNkK6_RVCRoznag" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="BtYHf38KbE2Woag0S8zVQw" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                    <Parameter id="GwheSER9tEO2NLFITiwBAg" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="Y5i-HZk9NUeoA7UKGgQIDg" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                    <Parameter id="o-KNiK73akO7yctTHh6PHw" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="hKXq5MVtGkCKHD0_pgT1Kg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="rEYIVUvvPk6ZMLQQ5JvKKA" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="p_bsa76dkkG6bsceP87FTg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="P1QMcOqMzECh6lofcnLRSg" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
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-                    <Parameter id="2qQ0jeq1Ckiq1vuD7gWnHg" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="l67xd6bdyUqAwiTT9QVtCg" visible="1" canBeVaried="1" />
-                    <Parameter id="NvTlxWVsek2QtdcSPqhSjg" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="X8aa6JXQB0-b6a-LH5_Krw" visible="0" canBeVaried="1" />
-                    <Parameter id="VGFqmZNNO0emBSkrkPwsjw" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="2iaBngQgI0qH_r5qEaH-Vg" visible="0" canBeVaried="0" />
-                    <Transport id="80xG66hTTUC05eMXg7GJeQ" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Transport" dimension="Amount per time" formula="7Y1gJ5cMSEO6lwlOqJr93w" sourceAmount="ogyOwK65X0uL1DkZot3EUA" targetAmount="-Vdyhy1qAEGZJkWudpNPKA" />
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-                <Parameter id="F6gRCObuvEadU4M86E2THg" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="hL1b37KxPky5KAcVFVg3CA" visible="1" canBeVaried="1" displayUnit="cm²" />
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-              <Tags>
-                <Tag value="Large intestine  neighborhood" />
-                <Tag value="Neighborhood: Plasma / Interstitial" />
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-              <Children>
-                <Container id="6XTItnQ-bkKZjhJRF7tmbQ" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="VL1nfjTVp0aqzJFRwoGEIw" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" visible="1" canBeVaried="1" value="10" displayUnit="cm/min" />
-                    <Parameter id="kOGyPRtOAkCVLzWpI017CA" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Bon9EHArSU6bcCi8KdWj7w" visible="1" canBeVaried="1" />
-                    <Transport id="oCgnobI31kmmHlYYiISYow" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Transport" dimension="Amount per time" formula="YSmrQ6ZqPEatTn_w8mCbiw" sourceAmount="xpcrmRU34EqRDnqQj6ZOeA" targetAmount="ogyOwK65X0uL1DkZot3EUA" />
-                  </Children>
-                </Container>
-                <Parameter id="rC7ukeajRkCo8_QntT31NA" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="H6x810lWk0mIQL7j67rvZw" visible="1" canBeVaried="1" displayUnit="cm²" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="kgDVquKVEkakv2bW1EpozA" name="LargeIntestine_pls_Caecum_pls" description="Neighborhood between Large Intestine/Plasma_ and Cecum/Plasma" mode="Logical" containerType="Other" firstNeighbor="uvQs1PS9aUqsBpd5BT5HkA" secondNeighbor="qk0qF8uZI06cnoMMMXTreA">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="h-JEc_sEEUqQVZtTrQJkOg" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="fe-QIr0P1UOeC5KJvjjLpw" name="Mass transfer rate (intestine to mucosa plasma)" description="Mass transfer rate (intestine to mucosa plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="wtf0y8SRrUKh_MqnsDuI5w" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Transport id="ADmxoDXV8UKEGhAhpSvILQ" name="MassTransferLINToMucosaPlasma" description="Mass transfer from Large Intestine:Plasma to Mucosa: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="AdChnpk9Lk2OUXhgfSMlSg" sourceAmount="xpcrmRU34EqRDnqQj6ZOeA" targetAmount="Lpte9WeV50K2AalO8MrxAw" />
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-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="Aob7tBcW3EGaXMQtNOlRzw" name="LargeIntestine_pls_PortalVein_pls" description="Neighborhood between Large Intestine/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="uvQs1PS9aUqsBpd5BT5HkA" secondNeighbor="-zX9e5Gif0qLF9-buV_xlA">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="qbrQBxuVJ0-J44JarjOyZA" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="S3EIPNokdkqfnxfbdKTLDA" name="MassTransferLinPlasma2BloodPool_Pve" description="Mass transfer from Large Intestine :Plasma to Portal Vein: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="gQXeLHqH3UWWRMrR3pQciA" sourceAmount="xpcrmRU34EqRDnqQj6ZOeA" targetAmount="hqBDuJ9j9Eqjy73I0KZSUA" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="IAQjwnDgTkiQGRkgbCZC8g" name="Liver_pls_Liver_bc" description="Neighborhood between Liver/Plasma and Liver/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="5FNaxPygXkWpARUfOC0rDA" secondNeighbor="5yZ7vQGKrEq4RZIcazhTBQ">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="sgwcXqPh_U-cXr6NpW0D8w" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="RI8SpWqpxEiAj2uru-WOlQ" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="38TepRSTOU-YZDpPCiJUhQ" sourceAmount="T_cXaPk7BEyWVth9NnrBzw" targetAmount="d0NG98bkQ0uyp6XKGUEC_Q" />
-                  </Children>
-                </Container>
-                <Parameter id="IkCXd61gNUevNQe-ZATsSQ" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="l_CwIVAygkmSagfFGluFSg" visible="1" canBeVaried="1" displayUnit="cm²" />
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-            </Neighborhood>
-            <Neighborhood id="wxLtOZEk5k-C9CcG44pxQA" name="Liver_pls_VenousBlood_pls" description="Neighborhood between Liver/Plasma and Venous Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="5FNaxPygXkWpARUfOC0rDA" secondNeighbor="J2AzZMiPQUibGWyUqz4XLA">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="D0jLDXE9rkGqim8Z0XR0Fg" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="j09A-4x7p0efO4ooc_W-yg" name="MassTransferOrgPl2BloodPool_Liv" description="Mass transfer from Liver: Plasma to Venous Blood: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="xNuAGXoR3EOONLFvaatGYA" sourceAmount="T_cXaPk7BEyWVth9NnrBzw" targetAmount="B3lPdr5IY0uIYf2oKyowmg" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="dpKn_yP7OUi8lW81fDQNJg" name="Liver_int_Liver_cell" description="Neighborhood between Liver/Interstitial and Liver/Intracellular" mode="Logical" containerType="Other" firstNeighbor="-H_ruFtnA0yNTMDWFWrpQA" secondNeighbor="paNIIwYocUKqmkMO_9k0pw">
-              <Tags>
-                <Tag value="Neighborhood: Interstitial / Intracellular" />
-              </Tags>
-              <Children>
-                <Container id="GuXcpr5VpE--g6lKTWFq_g" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="wnJZ5k2cukS3CloY-NIZdA" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="p_bsa76dkkG6bsceP87FTg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="KVRGB5iP90KtJ-2nJzeOhQ" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                    <Parameter id="ws25mmtobEer-Iut_h6vpQ" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="tlPA8QO9g02kkrY1yqEIAQ" visible="1" canBeVaried="1" />
-                    <Parameter id="aDUWKUiwREOyyr152QXLtQ" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="X8aa6JXQB0-b6a-LH5_Krw" visible="0" canBeVaried="1" />
-                    <Parameter id="HifaJXH4JkyMryfZOMMuKQ" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="hKXq5MVtGkCKHD0_pgT1Kg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="BeOjvrfTIUCXNnaNn9xy5w" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                    <Parameter id="rHM8Palr7UqD2-Iwf26eMg" name="Min (PA, Q)" description="Minimum between permeability and blood flow" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="TCCFmcpvJkm9vJ5E7hELeQ" visible="0" canBeVaried="0" displayUnit="l/min" />
-                    <Parameter id="Z4cEDOE8cU2vcKfGyXgU3A" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="BtYHf38KbE2Woag0S8zVQw" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                    <Parameter id="81bQ7slT10KF6-QZdE2JrQ" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="Y5i-HZk9NUeoA7UKGgQIDg" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                    <Parameter id="O1AMHwlui0GDoD6ZPnERjg" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="H-ASq1jSF0idEnPTIb2ITg" visible="0" canBeVaried="0" />
-                    <Transport id="Xt66c7QTn0iB6-sCcK3RKw" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Transport" dimension="Amount per time" formula="rCM0XrrEMEukuc2YApE9DQ" sourceAmount="LXffvaTUJkyiFK9g7Yg8Mg" targetAmount="SC75U6vf6UW32_Tid9pjFA" />
-                  </Children>
-                </Container>
-                <Parameter id="kzIO9Id9CEK0eMuo0ppsSA" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="EsjgPbxHV0-R3oPr9Rxw2A" visible="1" canBeVaried="1" displayUnit="cm²" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="6YSk-JhV2027Q96h3qE59w" name="Liver_pls_Liver_int" description="Neighborhood between Liver/Plasma and Liver/Interstitial" mode="Logical" containerType="Other" firstNeighbor="5FNaxPygXkWpARUfOC0rDA" secondNeighbor="-H_ruFtnA0yNTMDWFWrpQA">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Interstitial" />
-              </Tags>
-              <Children>
-                <Container id="t18jJF5ohUKi-P2DNzRgkg" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="UHtFuXGBDUqUqj_7ol6Mow" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" visible="1" canBeVaried="1" value="10" displayUnit="cm/min" />
-                    <Parameter id="PAo8o-XCAUex5XWnAdRmqA" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Bon9EHArSU6bcCi8KdWj7w" visible="1" canBeVaried="1" />
-                    <Transport id="Ls6VSM9pFEKK698cpCQFrg" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Transport" dimension="Amount per time" formula="TYnvXyuujkm982JYAVtCnQ" sourceAmount="T_cXaPk7BEyWVth9NnrBzw" targetAmount="LXffvaTUJkyiFK9g7Yg8Mg" />
-                  </Children>
-                </Container>
-                <Parameter id="8vXoXC2PZEWTDBXSwbumaw" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="DP1GtIeJJESM7zUETJOL3Q" visible="1" canBeVaried="1" displayUnit="cm²" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="DTwZOvkfYEqdchnauvp7rw" name="Gallbladder_Lumen_duo" description="Gallbladder and Lumen/Duodenum" mode="Logical" containerType="Other" firstNeighbor="4wG1HdnR90upld7ARMVVbw" secondNeighbor="RBDgGJ__rUCEJi-Z5h0eyg">
-              <Tags>
-                <Tag value="Neighborhood: Gallbladder / Duodenum" />
-              </Tags>
-              <Children>
-                <Container id="vBjkc4PFeUCmEBaeWAfI9A" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="IORss-F35ESdyNCA6BA2fw" name="GallbladderEmptying" description="Gallbladder emptying" mode="Logical" containerType="Transport" dimension="Amount per time" formula="gBElZyhXd0W-JG3tFIzrWA" sourceAmount="kzqdDdO1KkGPTLPLhNAn8Q" targetAmount="BaeHcf6VhUyw3ftOPt1iIg" />
-                  </Children>
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-            </Neighborhood>
-            <Neighborhood id="XV9NNSPpUUKenvC6umsTFA" name="Liver_cell_Lumen_duo" description="Neighborhood between Liver/Intracellular and Lumen/Duodenum" mode="Logical" containerType="Other" firstNeighbor="paNIIwYocUKqmkMO_9k0pw" secondNeighbor="RBDgGJ__rUCEJi-Z5h0eyg">
-              <Tags>
-                <Tag value="Neighborhood: Intracellular / Duodenum" />
-              </Tags>
-              <Children>
-                <Container id="_166zfKWBUWrXRkp_KBM6Q" name="C1" mode="Logical" containerType="Molecule" />
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-            </Neighborhood>
-            <Neighborhood id="e_nPM2UnkkyHaJeAqCOLlg" name="Liver_cell_Gallbladder" description="Neighborhood between Liver/Intracellular and Gallbladder" mode="Logical" containerType="Other" firstNeighbor="paNIIwYocUKqmkMO_9k0pw" secondNeighbor="4wG1HdnR90upld7ARMVVbw">
-              <Tags>
-                <Tag value="Neighborhood: Intracellular / Gallbladder" />
-              </Tags>
-              <Children>
-                <Container id="y3jB6lU4VUa-DZQMqp5u6A" name="C1" mode="Logical" containerType="Molecule" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="289XPF7szUG4zIAbEn6UxA" name="Liver_bc_VenousBlood_bc" description="Neighborhood between Liver/Blood Cells and Venous Blood/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="5yZ7vQGKrEq4RZIcazhTBQ" secondNeighbor="HLhY21FI2UuJWgRMTu6RlA">
-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="PkesQeHNTEafg0xJ9mLZFA" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="LIudNZgtGUynm2MBTwgLoQ" name="MassTransferOrgRBC2BloodPool_Liv" description="Mass transfer from Liver: Blood Cells to Venous Blood: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="GzVEjqnOUUyvO1EI-E1Uxw" sourceAmount="d0NG98bkQ0uyp6XKGUEC_Q" targetAmount="GWJuEfO1Xkqh3wAfzsLyqQ" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="DgS-zE99CUKcBtxW4_nveQ" name="Lung_pls_Lung_bc" description="Neighborhood between Lung/Plasma and Lung/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="HoKbo31Lg0yRHlM9oyiwmQ" secondNeighbor="bR9hD2e26EiSVp_aH2gLlA">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="fywF993fBEmlAsGB9pT2Lw" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="PNtcB1zSf0iUQIxw_ym_oA" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="beJz03zeXkm9uq3fDT5BBA" sourceAmount="gbZpi5a1-EC-twcuHrfa2Q" targetAmount="Al9BXU4-TkesaoCcONO8ow" />
-                  </Children>
-                </Container>
-                <Parameter id="IU6gIGqmHEyWCBxGHT7LKg" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="3tLcsT3eBEexebrV-ULsqQ" visible="1" canBeVaried="1" displayUnit="cm²" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="xjeUdggf20u9fJR2kCDPHA" name="Lung_pls_Lung_int" description="Neighborhood between Lung/Plasma and Lung/Interstitial" mode="Logical" containerType="Other" firstNeighbor="HoKbo31Lg0yRHlM9oyiwmQ" secondNeighbor="92JykqpZS0GTuPIIOzwT1A">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Interstitial" />
-              </Tags>
-              <Children>
-                <Container id="YyQUj3bevkmuB_BJz-XLdw" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="DYkG0UD9w0O7wo170I1cJA" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Bon9EHArSU6bcCi8KdWj7w" visible="1" canBeVaried="1" />
-                    <Parameter id="n3KYen8vv0q38dV7U5mwDQ" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" visible="1" canBeVaried="1" value="10" displayUnit="cm/min" />
-                    <Transport id="6v5ZLGpIvkGxX4i1Fe9jPA" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Transport" dimension="Amount per time" formula="W_dduNdJYkuv8orgh-tyQA" sourceAmount="gbZpi5a1-EC-twcuHrfa2Q" targetAmount="JrrWuXePoECZbaojfjCbcg" />
-                  </Children>
-                </Container>
-                <Parameter id="T7V36iab-EGnATPXymfQXQ" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="HHdMh0ervEilhie9UEQ6KA" visible="1" canBeVaried="1" displayUnit="cm²" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="XCtaZ5eYvEiQKi5swBWu6Q" name="Lung_pls_ArterialBlood_pls" description="Neighborhood between Lung/Plasma and Arterial Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="HoKbo31Lg0yRHlM9oyiwmQ" secondNeighbor="qJqHlxhje0erBO7-fTj4-g">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="FH3NHr5m8kyKFOhOZsodrA" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="SZUHRKoPqUOrpV6baNitig" name="MassTransferOrgPl2BloodPool_Lng" description="Mass transfer from Lung: Plasma to Arterial Blood: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="AUnT1K-hCUqHuqVeH4NoJA" sourceAmount="gbZpi5a1-EC-twcuHrfa2Q" targetAmount="n0un2GZNyUWFQsjdUS5RGA" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="P1qPkifr30uwf079Vx7fjA" name="Lung_bc_ArterialBlood_bc" description="Neighborhood between Lung/Blood Cells and Arterial Blood/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="bR9hD2e26EiSVp_aH2gLlA" secondNeighbor="0_QXjFTwnEy8-V1CtkHsew">
-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="LmDkWHWRLUCxuavFWLa-rQ" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="jideJVeqNECN2ON1jFFSdw" name="MassTransferOrgRBC2BloodPool_Lng" description="Mass transfer from Lung: Blood Cells to Arterial Blood: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="Gy4BZLClQk2WqIDTRGK7LQ" sourceAmount="Al9BXU4-TkesaoCcONO8ow" targetAmount="HVsSKkWIVECLvyey2mYIPw" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="-D-BzPQvgkSmpGFDMAeYjQ" name="Lung_int_Lung_cell" description="Neighborhood between Lung/Interstitial and Lung/Intracellular" mode="Logical" containerType="Other" firstNeighbor="92JykqpZS0GTuPIIOzwT1A" secondNeighbor="mK6pvtoPv0-s3SurtE-G7A">
-              <Tags>
-                <Tag value="Neighborhood: Interstitial / Intracellular" />
-              </Tags>
-              <Children>
-                <Container id="EA0L2rQz7EezstbuCLMTww" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="UuueXzvhNk6YoOIzeZpX6w" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="BtYHf38KbE2Woag0S8zVQw" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                    <Parameter id="3Mqd41_zvUuSmLGLQFWOcA" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="Y5i-HZk9NUeoA7UKGgQIDg" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                    <Parameter id="rtz-sMdgP0SfsZXe2sAIZg" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="hKXq5MVtGkCKHD0_pgT1Kg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="FpvwfR4s7Em3NKCigFdHZA" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="p_bsa76dkkG6bsceP87FTg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="4XIhGvfuv0C9j8v8eTEavQ" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                    <Parameter id="yDH4URJdnUCx_6hHGmxURQ" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                    <Parameter id="etfpuGyyFkyPjAHhCiVxBw" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="5SQhw71znkmDuNLi71LfJQ" visible="1" canBeVaried="1" />
-                    <Parameter id="m0_BPt6PyUK7vuBDr2BmqA" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="X8aa6JXQB0-b6a-LH5_Krw" visible="0" canBeVaried="1" />
-                    <Parameter id="qmELmqjJK0SvIu3j3JlRnQ" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="waC5EOkDREWXaBlTS5iJ9Q" visible="0" canBeVaried="0" />
-                    <Transport id="PWKIxtSmx0ykNNaSqE1Fvw" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Transport" dimension="Amount per time" formula="2U4Nx1VZ7EeBQmbiPoD6vA" sourceAmount="JrrWuXePoECZbaojfjCbcg" targetAmount="UXxsrAk_FkaJLEuUOEK0eQ" />
-                  </Children>
-                </Container>
-                <Parameter id="e08wHxBz9kqWaPqRyJiOrw" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="u21WZXdHyk-FGea3q-Ralg" visible="1" canBeVaried="1" displayUnit="cm²" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="7q3W2P-zmEmqlYRjBjMhpw" name="Muscle_int_Muscle_cell" description="Neighborhood between Muscle/Interstitial and Muscle/Intracellular" mode="Logical" containerType="Other" firstNeighbor="a1qYPg4xpUGRsgFsJP-ksA" secondNeighbor="bw5p5F5Dk0muSFhqeOE0AQ">
-              <Tags>
-                <Tag value="Neighborhood: Interstitial / Intracellular" />
-              </Tags>
-              <Children>
-                <Container id="PUOpGFiLkEOULMbb0RVZ9A" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="aaVzFy69Kkm2jHeHQu_97A" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                    <Parameter id="6jhRtjk2sEevW4kfO4_I_Q" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="BtYHf38KbE2Woag0S8zVQw" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                    <Parameter id="TIq9_TZC_02fXRDhHt9KGw" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="Y5i-HZk9NUeoA7UKGgQIDg" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                    <Parameter id="sG6t5lVuyEiRXeuiJfGbFA" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="p_bsa76dkkG6bsceP87FTg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="PdpqAR4ZxEWIh2uARRsFLg" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                    <Parameter id="ruLREIrfbE-cP397DykPfg" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="LgsxCVX-w0qsIuX0U4HSlg" visible="1" canBeVaried="1" />
-                    <Parameter id="oAP9gVI490CmKz2JvhkgMQ" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="X8aa6JXQB0-b6a-LH5_Krw" visible="0" canBeVaried="1" />
-                    <Parameter id="pMYj_2FxN0WOyofrMdz_jw" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="hKXq5MVtGkCKHD0_pgT1Kg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="elgsMZdJdUStwCpW47lEkA" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="-2QOt9DwGUeLqbN-vpgFnw" visible="0" canBeVaried="0" />
-                    <Transport id="XFLD9ettJUiT0c6tyt06BA" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Transport" dimension="Amount per time" formula="y0NiimBy3E6bio0ExkCeyA" sourceAmount="p3qnjhvmwUO-jJ5G4Wrs5g" targetAmount="asjC6lALQEGEMpPCFGvZwA" />
-                  </Children>
-                </Container>
-                <Parameter id="NuavbeXKyEy0NTDTOCwNxQ" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="wCJsHd9c8EuU8pmym0uo0Q" visible="1" canBeVaried="1" displayUnit="cm²" />
-              </Children>
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-            <Neighborhood id="w495R20XpEKXgCbBy9-DWA" name="Muscle_pls_Muscle_bc" description="Neighborhood between Muscle/Plasma and Muscle/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="XRLei8Ut4k69NW71TsrsFA" secondNeighbor="_qU5KwpSU0W_lpkw1fcMqg">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="Q6_cFJ6OLECEHVteYHv9Gg" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="YfWLAfqLzkSSNOQW188vRA" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="YPilNuuAvEOn22na2AmPlA" sourceAmount="JbH2ysob6kW6Qm7S2hrU2g" targetAmount="27a1Npm_QEaEQOPqqma4rw" />
-                  </Children>
-                </Container>
-                <Parameter id="3PNYtEBQZUOuqDpm5oC7hg" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="6DikydZ00EiVs-NoKqIk6Q" visible="1" canBeVaried="1" displayUnit="cm²" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="Eb7fe0mdvUmBVZkqvG46aQ" name="Muscle_pls_Muscle_int" description="Neighborhood between Muscle/Plasma and Muscle/Interstitial" mode="Logical" containerType="Other" firstNeighbor="XRLei8Ut4k69NW71TsrsFA" secondNeighbor="a1qYPg4xpUGRsgFsJP-ksA">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Interstitial" />
-              </Tags>
-              <Children>
-                <Container id="0RU4mlvcGUqfphWADGq2Xw" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="C5mP6mo9RUeeMlfQEkj0_A" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" visible="1" canBeVaried="1" value="10" displayUnit="cm/min" />
-                    <Parameter id="l_tlYH92tUGHWZcfDxdSpA" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Bon9EHArSU6bcCi8KdWj7w" visible="1" canBeVaried="1" />
-                    <Transport id="fdD7_maFqEeXeViFCk8zqA" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Transport" dimension="Amount per time" formula="WaWpecUjd0my6WXEVrLZPg" sourceAmount="JbH2ysob6kW6Qm7S2hrU2g" targetAmount="p3qnjhvmwUO-jJ5G4Wrs5g" />
-                  </Children>
-                </Container>
-                <Parameter id="cnE89ozDn0qoZHhLiRLnew" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="_prtB154DEynF1Ja3O2O0g" visible="1" canBeVaried="1" displayUnit="cm²" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="Oy1aZ4O_C0qdlCLjHy_00g" name="Muscle_pls_VenousBlood_pls" description="Neighborhood between Muscle/Plasma and Venous Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="XRLei8Ut4k69NW71TsrsFA" secondNeighbor="J2AzZMiPQUibGWyUqz4XLA">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="wJaRVjpR90G00Xs3lIamPg" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="BtQCZIOQ30Gtq31rkvoogA" name="MassTransferOrgPl2BloodPool" description="Mass transfer from organ: Plasma to Venous Blood: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="foZfdkJgLUqrLTzmywqE1Q" sourceAmount="JbH2ysob6kW6Qm7S2hrU2g" targetAmount="B3lPdr5IY0uIYf2oKyowmg" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="R_KDn8F_GkSKvAVP690KWA" name="Muscle_bc_VenousBlood_bc" description="Neighborhood between Muscle/Blood Cells and Venous Blood/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="_qU5KwpSU0W_lpkw1fcMqg" secondNeighbor="HLhY21FI2UuJWgRMTu6RlA">
-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="OxdVQMRdw0OaabHjemw11g" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="7SXvph8KcUetUTBfqEZF7A" name="MassTransferOrgRBC2BloodPool" description="Mass transfer from organ: Blood Cells to Arterial Blood: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="rklLkWWbxkafPB5p5nCVBg" sourceAmount="27a1Npm_QEaEQOPqqma4rw" targetAmount="GWJuEfO1Xkqh3wAfzsLyqQ" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="0Zj5OKR8MkaRz-1v8v3smg" name="Pancreas_pls_Pancreas_bc" description="Neighborhood between Pancreas/Plasma and Pancreas/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="cctLJe2tcEmrG89fHAxBug" secondNeighbor="MeBFC58XdEOor4pLtkobow">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="HIbkHWi0S0qXPlH05lrUZg" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="BX1ELVaO50uFdTxJkyCHYQ" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="cNugkpcupEirM29eL2sM3g" sourceAmount="5o8ad95eVkm36IzpkEUdTg" targetAmount="REWBabOvWEqf_0a-yS75TA" />
-                  </Children>
-                </Container>
-                <Parameter id="vmRM4XOpN0O_ORdeJzVFAg" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="yoKxcwqdf0-F9E1YSvFDug" visible="1" canBeVaried="1" displayUnit="cm²" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="BdN27C-2VESQ_ZtFnk0b6Q" name="Pancreas_pls_Pancreas_int" description="Neighborhood between Pancreas/Plasma and Pancreas/Interstitial" mode="Logical" containerType="Other" firstNeighbor="cctLJe2tcEmrG89fHAxBug" secondNeighbor="7rzA5jsVpEabSReHCrcXRQ">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Interstitial" />
-              </Tags>
-              <Children>
-                <Container id="Y_iR5_LCqka30sHQ9crmGg" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="lvItY7xqyUWggcTWMAIK9A" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Bon9EHArSU6bcCi8KdWj7w" visible="1" canBeVaried="1" />
-                    <Parameter id="oi8KwrIun0ifCgrtN0Ek0g" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" visible="1" canBeVaried="1" value="10" displayUnit="cm/min" />
-                    <Transport id="EUf3aGdCL0iOLLbrP78xgQ" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Transport" dimension="Amount per time" formula="6Av5vanvR02dPBp9u38diA" sourceAmount="5o8ad95eVkm36IzpkEUdTg" targetAmount="aJsCxm_rBEyUmMry1Ys8-A" />
-                  </Children>
-                </Container>
-                <Parameter id="itan83ILAU-bbt4WLg4_Lw" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="GfltgqGXFkCbrFLFwr3jOQ" visible="1" canBeVaried="1" displayUnit="cm²" />
-              </Children>
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-            <Neighborhood id="XmWlKPWqHUOJT7BVf2oefw" name="Pancreas_pls_PortalVein_pls" description="Neighborhood between Pancreas/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="cctLJe2tcEmrG89fHAxBug" secondNeighbor="-zX9e5Gif0qLF9-buV_xlA">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="4V_FnaK-lE29kncdXW4W5g" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="ine4TqZKcEGV8rDOQ-0AKQ" name="MassTransferOrgPl2BloodPool_pve" description="Mass transfer from organ: Plasma to Portal Vein: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="Pxvw60FxjEyS5_Sj0T8NzA" sourceAmount="5o8ad95eVkm36IzpkEUdTg" targetAmount="hqBDuJ9j9Eqjy73I0KZSUA" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="MvOBP2iLpUOtSSDEdzSyzA" name="Pancreas_int_Pancreas_cell" description="Neighborhood between Pancreas/Interstitial and Pancreas/Intracellular" mode="Logical" containerType="Other" firstNeighbor="7rzA5jsVpEabSReHCrcXRQ" secondNeighbor="4iU46nMqvEmor7uOHn6qnA">
-              <Tags>
-                <Tag value="Neighborhood: Interstitial / Intracellular" />
-              </Tags>
-              <Children>
-                <Container id="ZWKltGX8vUiWAEpHgwUeSQ" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="vqsgWBK4cU6KXdxBqIAGNw" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="BtYHf38KbE2Woag0S8zVQw" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                    <Parameter id="iwaoyHnSPk2pdUYf4zUblw" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="Y5i-HZk9NUeoA7UKGgQIDg" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                    <Parameter id="BwmwJz_09kivFHPu_vkEUQ" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="hKXq5MVtGkCKHD0_pgT1Kg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="a1YBLOy1nUqd04byfpPhBg" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="p_bsa76dkkG6bsceP87FTg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="zkY5ImczkUmKXru_DY_4zg" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                    <Parameter id="sNrshl12DUKS4jkUCrfjzQ" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                    <Parameter id="FmFre2mtO0ayQwe-MBeIKA" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="pg_CNu7U2Em-fPA8g_1ROA" visible="1" canBeVaried="1" />
-                    <Parameter id="6EKJxY-ZiEmiHlfCmPOpOA" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="X8aa6JXQB0-b6a-LH5_Krw" visible="0" canBeVaried="1" />
-                    <Parameter id="ekcxh6mBvke1Uod5-nRerQ" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Jhe-K99W-0iv7V1UhuZqnA" visible="0" canBeVaried="0" />
-                    <Transport id="vh1lTAa3fk-X3-jGzr1LRA" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Transport" dimension="Amount per time" formula="Oe7oDdMgJkeUBT8vwmP0WA" sourceAmount="aJsCxm_rBEyUmMry1Ys8-A" targetAmount="3CMuUyM7XkaDQ4QllGx09Q" />
-                  </Children>
-                </Container>
-                <Parameter id="-_6IQwJ65U6rBUoU2xsUPw" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="zjpus8_DUUaIZGsqB9g0GA" visible="1" canBeVaried="1" displayUnit="cm²" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="71Ro6GoFkkychfbUsfIWIQ" name="Pancreas_bc_PortalVein_bc" description="Neighborhood between Pancreas/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="MeBFC58XdEOor4pLtkobow" secondNeighbor="V3IajphOTUWt3a2j9_LOZA">
-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="6PwxgIBnMEmDDJSa7Bm91A" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="1_ojdiWK0kCI_5DNHL5x1Q" name="MassTransferOrgRBC2BloodPool_Pve" description="Mass transfer from organ: Blood Cells to Portal Vein: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="rSYAN85kEk-zmTybMXhnCw" sourceAmount="REWBabOvWEqf_0a-yS75TA" targetAmount="3A4PxVITtUOpr85RBMQZlg" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="lrC48EzxwEiI9YN-9_WsgQ" name="Lumen_rect_Rectum_cell" description="Neighborhood between Lumen/Rectum and Mucosa/Rectum/Intracellular" mode="Logical" containerType="Other" firstNeighbor="eprwABQUEkOQApydkOYKug" secondNeighbor="xqyjpic_fU-nSEKNKkYMGw">
-              <Tags>
-                <Tag value="Neighborhood: Rectum / Intracellular" />
-              </Tags>
-              <Children>
-                <Container id="rHmIvIft50-7kClxKAOhkg" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="fARsqqC4Hka0TMkpI2F__w" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="xMZNhihqpEKgsl6d4EbxCw" visible="0" canBeVaried="0" />
-                    <Parameter id="GHvKNj_g9kGj2c1qqhtR7w" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="XIA8Hwb6Cka-ABuXXYcQDw" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="e_M7DbpNo02LKEqDgm6KrA" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="bOPO_JT8sEOF6PITZSGGVg" visible="0" canBeVaried="0" />
-                    <Parameter id="i4CeXCv8qkON9-5uAYZo-Q" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="aZYSS2yfyEqUEbGBDu38yg" visible="0" canBeVaried="0" />
-                    <Parameter id="oEUmTGA0SUCamEG60qNIAw" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Dgge5YlnU02lbR1txIXNGg" visible="0" canBeVaried="0" />
-                    <Parameter id="5ENocGF7jkeKckGau1Pwgw" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="s5I7M-OHO023bLOHJj3bcg" visible="0" canBeVaried="0" />
-                    <Parameter id="5hgaulW4WkOXwq0atsp09Q" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="GpVIfp-Ack-XNmChagqotA" visible="0" canBeVaried="1" />
-                    <Parameter id="36pSUzhM0kuBmbL94HFYng" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="aWekJ2NVAECIIbxJKJ8L5g" visible="0" canBeVaried="0" />
-                    <Parameter id="_yGf9pE0NE-EzkESSOIW8g" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="WiAF34zdQ0Cn9Ni1vX1juA" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="1NluvF7YOUugRAQPM5I-xQ" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="jmeH5OyMqUSc9qE8Binaag" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="gnnQ6fP8nEeSBPFOh-H8TQ" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="gxoZyuApjEuzsuLtZuZWmQ" visible="0" canBeVaried="0" />
-                    <Parameter id="kHaCYZyxdEiTPlR4CVBsaw" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="MUYCMxBgqESbYoBitI72kA" visible="0" canBeVaried="0" />
-                    <Parameter id="hlFzqzy8LEi7YNCcACtROg" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="qb_xgn5bmEOWpUBl1kqmUA" visible="0" canBeVaried="0" />
-                    <Parameter id="u3P4yTLKgU-OM2KDDeEPfQ" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="0IIh6FJV0UKyrimES0f1xg" visible="0" canBeVaried="0" />
-                    <Parameter id="OtjAmhbZXEuMA067UqXTKQ" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="KQgllSQtqk2EfhX37WilDQ" visible="0" canBeVaried="0" />
-                    <Parameter id="fjOfewjcxU-s0thqlukvxQ" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="7NEiCDSKM0i6GhEpoWb-Mw" visible="0" canBeVaried="0" />
-                    <Parameter id="76RGZ5ac1ECGE4yEKQLo1g" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="3xvkxp6qK06bn4DgEtYULA" visible="0" canBeVaried="0" />
-                    <Parameter id="BUqa4v9BrUCAIAbbdS_NlQ" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="ezAHDPnckEKYf8L1jOtGfw" visible="0" canBeVaried="0" />
-                    <Parameter id="Ari5YXVNSUmZ_ofiJDmnlQ" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="2IVWcgM31UCSVl8zMDnDhw" visible="0" canBeVaried="0" />
-                    <Parameter id="CEZ1Vl8LUU6GeHOH4v9b_Q" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Iph7YhQ5KUmsZWUX2Xf2Wg" visible="0" canBeVaried="0" />
-                    <Parameter id="Rg4uGUMx9EamIKaHwidT8g" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="LcUCvhU3W0udtbpS1KVhEQ" visible="0" canBeVaried="0" />
-                    <Parameter id="8NAWIszRCkW1ErAKcd6qEg" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="qr_x2cq_Y0C6Ur-VSCP4AQ" visible="0" canBeVaried="0" />
-                    <Parameter id="xKfz73Y-T02X5GzVzz0MBg" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="NREbm1IgPECCMxntCfyWiQ" visible="0" canBeVaried="0" />
-                    <Parameter id="041vYBBpb064w75Y9UmF_g" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="vSO_MC1JA0mChxdPA-XoGw" visible="0" canBeVaried="0" />
-                    <Parameter id="Cjq4RsCn9EKs7CffoP2R7g" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="PEhoVdLppU-G3xULjX_71g" visible="0" canBeVaried="0" />
-                    <Parameter id="ZEgE6XvkFkyXvz9kV2VgrQ" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="pGvG5UNdC0Sot3_d3Qdvag" visible="0" canBeVaried="0" />
-                    <Parameter id="aE5sdkn2M02M5bD3WXNvLA" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="jJfeJ2YxEki9TK9XP6uUMA" visible="0" canBeVaried="0" />
-                    <Parameter id="fZWzShi7uU-U5IwjMl2h8Q" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DNF0kWPUFk-rtSd0Ng1Mkw" visible="0" canBeVaried="0" />
-                    <Parameter id="W3MB9dikv0yxk8Ph-yBmeg" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DNGx_vFWp0KdOb7CGcoTLQ" visible="0" canBeVaried="0" />
-                    <Transport id="fVtYZMBrz0-C_m2ustBJtg" name="DrugAbsorption_trans" description="Drug absorption transcellular" mode="Logical" containerType="Transport" dimension="Amount per time" formula="KK9g_ZIbk0ymfNqNAETXzA" sourceAmount="2kdpKYdY3EeBvJPRNS1TEg" targetAmount="QVE4GWVZMEmvb2TwJk78sQ">
-                      <Children>
-                        <Parameter id="SdrxBn9MukeNIIOr5mPQVQ" name="ProcessRate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="7IAl1PYIyU-zyu6IqQUE4g" visible="0" canBeVaried="1" displayUnit="µmol/min">
-                          <Tags>
-                            <Tag value="DrugAbsorption_trans" />
-                            <Tag value="ProcessRate" />
-                            <Tag value="C1" />
-                            <Tag value="Lumen_rect_Rectum_cell" />
-                            <Tag value="Passive" />
-                          </Tags>
-                        </Parameter>
-                      </Children>
-                    </Transport>
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="7eAyEQjlqkWL7yWbTbNZ0g" name="Rectum_pls_PortalVein_pls" description="Neighborhood between Rectum/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="WMIBikKwrEe1vMFMiv-ong" secondNeighbor="-zX9e5Gif0qLF9-buV_xlA">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="GOVEaFAIYU2pXtHTqtdFxg" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="j12ETevWsUynb7hjrLTTkA" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="9XHjLuJnUkqhlXb3EQzr1w" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Transport id="eltFZGqVn0CoLIRv8YPt_w" name="MassTransferMucosaToPvePlasma" description="Mass transfer from Mucosa:Plasma To Portal Vein: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="7J1UFBBLAUCHC563vmLm8w" sourceAmount="w16XRTEu1kCkEKI9PKRZEg" targetAmount="hqBDuJ9j9Eqjy73I0KZSUA" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="1Rw_IaS0GEKfO5CxKAdiiQ" name="Rectum_bc_PortalVein_bc" description="Neighborhood between Rectum/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="XuC4VFLrok2cYGGvu6Zk6A" secondNeighbor="V3IajphOTUWt3a2j9_LOZA">
-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="75ZsegOPAUSHSDpmxmsP9A" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="NLs5l8Ix_ESovVg3Ntg4eA" name="Mass transfer rate (mucosa to portal vein blood cells)" description="Mass transfer rate (mucosa to portal vein blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="UybmXii5q0qBPyZHTkgV8A" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Transport id="K3ps_KBwykCSVvJCpamMMw" name="MassTransferMucosaToPveBC" description="Mass transfer from Mucosa:Blood Cells To Portal Vein: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="Ddlo4PcB-kunD1pva3cVSw" sourceAmount="r0gwYEI_O0mcxiowmhPpKQ" targetAmount="3A4PxVITtUOpr85RBMQZlg" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="iAKB7DYeAEK8w2ZQqZ6bxg" name="Lumen_rect_Rectum_pls" description="Neighborhood between Lumen/Rectum and Mucosa/Rectum/Plasma" mode="Logical" containerType="Other" firstNeighbor="eprwABQUEkOQApydkOYKug" secondNeighbor="WMIBikKwrEe1vMFMiv-ong">
-              <Tags>
-                <Tag value="Neighborhood: Rectum / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="pkVOB6zxFkue2FZE0bYgjQ" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="Cp_TQiR4WUewT7P-xYuOGw" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="ts61JbLRVk2xt3IFmtfObQ" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="gG-N1H1Vt0OAZRaQYqfagA" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="ZjQKDR1WS0Cu5v8IvPpkyw" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="i0HbXAafD06K1Y7pYuxHaA" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="gbcgQy55CEqF3Rb8WMyH-Q" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="cSHJspOLo06W2CHqoOLj0Q" name="PortalVein_pls_Liver_pls" description="Neighborhood between PortalVein/Plasma and Liver/Plasma" mode="Logical" containerType="Other" firstNeighbor="-zX9e5Gif0qLF9-buV_xlA" secondNeighbor="5FNaxPygXkWpARUfOC0rDA">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="fgwO8XBXEU6ikgDoeD-rbA" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="DgRhbwsCUk2rE_eXOe1Kdw" name="MassTransferBloodPool2OrgPl_liv" description="Mass transfer from Portal Vein: Plasma to Liver: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="Nw25zENgS0eFRhlNrAlvng" sourceAmount="hqBDuJ9j9Eqjy73I0KZSUA" targetAmount="T_cXaPk7BEyWVth9NnrBzw" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="f3pOhz9W-EaCgbzJk6oBLw" name="PortalVein_pls_PortalVein_bc" description="Neighborhood between PortalVein/Plasma and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="-zX9e5Gif0qLF9-buV_xlA" secondNeighbor="V3IajphOTUWt3a2j9_LOZA">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="ydPpCaTIVk6HNnlhbp2CQg" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="OLDQqXg_k0C0jx_EDBsJbQ" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="830OU_D3qkC0AxHZZZBiag" sourceAmount="hqBDuJ9j9Eqjy73I0KZSUA" targetAmount="3A4PxVITtUOpr85RBMQZlg" />
-                  </Children>
-                </Container>
-                <Parameter id="Jho1pj_NAUqZf6Wy-_I4nQ" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="XaYmnJqT40SQfI_qEvTaGA" visible="1" canBeVaried="1" displayUnit="cm²" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="XApNVjUOcU63GhViSyi6kw" name="PortalVein_bc_Liver_bc" description="Neighborhood between PortalVein/Blood Cells and Liver/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="V3IajphOTUWt3a2j9_LOZA" secondNeighbor="5yZ7vQGKrEq4RZIcazhTBQ">
-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="QUiWA1DMUESVoepd-6Qf4w" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="vIWC7Cd30kiN86-c7IfCIw" name="MassTransferBloodPool2OrgRBC_liv" description="Mass transfer from Portal Vein: Blood Cells to Liver: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="buQ3bJBqJUiCyKdE9jZ5iQ" sourceAmount="3A4PxVITtUOpr85RBMQZlg" targetAmount="d0NG98bkQ0uyp6XKGUEC_Q" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="3IFTikoRrES2h_xTCaNE-A" name="Skin_pls_VenousBlood_pls" description="Neighborhood between Skin/Plasma and Venous Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="Xg7ardQtf0-u4B4xI_Q48w" secondNeighbor="J2AzZMiPQUibGWyUqz4XLA">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="D7m8QlvZJEi12sKMF68KEw" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="Cn2N5jo8VUqKFtT-aVOmbA" name="MassTransferOrgPl2BloodPool" description="Mass transfer from organ: Plasma to Venous Blood: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="0aSPdE9iqky2KIko-emuAQ" sourceAmount="FRvVMGhi8UOBMOTbm5lolA" targetAmount="B3lPdr5IY0uIYf2oKyowmg" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="4s-7CgEIukS8E6eDHq5vyg" name="Skin_pls_Skin_bc" description="Neighborhood between Skin/Plasma and Skin/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="Xg7ardQtf0-u4B4xI_Q48w" secondNeighbor="4S7otm2HZU6QSl2UbAf8-Q">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="hX5sF150fkeGOLIpdVP6_w" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="D3potbfcIU6p_dT5hcuRTQ" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="KpHgtez6o0O8z8TpRJ5fZA" sourceAmount="FRvVMGhi8UOBMOTbm5lolA" targetAmount="DhjTerwdiEag5vbskJtPZw" />
-                  </Children>
-                </Container>
-                <Parameter id="IL7kSm8QL0aqtCS14KdNVA" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="Pwgx7i-bvkeaCbuutKJV-g" visible="1" canBeVaried="1" displayUnit="cm²" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="Vymu_4BZ8EmNBnIQbkhr0g" name="Skin_int_Skin_cell" description="Neighborhood between Skin/Interstitial and Skin/Intracellular" mode="Logical" containerType="Other" firstNeighbor="b8bNjxZMnEWJmwenwTXm_w" secondNeighbor="Pxv8-fk5WEym452UPM8-Tw">
-              <Tags>
-                <Tag value="Neighborhood: Interstitial / Intracellular" />
-              </Tags>
-              <Children>
-                <Container id="-t095YIUNUK6JQB74EP-6g" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="yNi4sF89MU29iNHX7Yh9Bg" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                    <Parameter id="y_K4_dVqpkKBRV5kQicIiw" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="KA9D0qZp6ESm0OGlCepAtA" visible="1" canBeVaried="1" />
-                    <Parameter id="EwL9ySJ55kCzWyTWwE3a9w" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="X8aa6JXQB0-b6a-LH5_Krw" visible="0" canBeVaried="1" />
-                    <Parameter id="5YEePCVbb0GyDYuxlQKB_A" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="hKXq5MVtGkCKHD0_pgT1Kg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="0qDbFywBBUWqTIFKllPRkA" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                    <Parameter id="fqi45-9NakuJs7BO2xjT1Q" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="p_bsa76dkkG6bsceP87FTg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="f-eq3eaq-kGA9403upeaMQ" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="BtYHf38KbE2Woag0S8zVQw" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                    <Parameter id="K-sW_YnCqEi_bmTks3qywg" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="Y5i-HZk9NUeoA7UKGgQIDg" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                    <Parameter id="CT90n_DEDUepb1RX3Hmnzg" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CE1nwk1uoUG0Dz3ad5-p-A" visible="0" canBeVaried="0" />
-                    <Transport id="oC_VuxEC5UmKubIr_p7gfA" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Transport" dimension="Amount per time" formula="bT45RzpYK0Ch2FkIw8NNUw" sourceAmount="YMmIlmXRvkKumHoleo8cVg" targetAmount="uLbNIRBmAU-vgjgQdeohRQ" />
-                  </Children>
-                </Container>
-                <Parameter id="KToaxYW-GUCRBB-DR3IfIw" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="aHT9WttymkCcQ_EXXopgRQ" visible="1" canBeVaried="1" displayUnit="cm²" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="rjWwTdqZGEOhQvRtHSzRMw" name="Skin_pls_Skin_int" description="Neighborhood between Skin/Plasma and Skin/Interstitial" mode="Logical" containerType="Other" firstNeighbor="Xg7ardQtf0-u4B4xI_Q48w" secondNeighbor="b8bNjxZMnEWJmwenwTXm_w">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Interstitial" />
-              </Tags>
-              <Children>
-                <Container id="dT5Tb1e-pUKPPp0vWYq6EA" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="7WXki_KSfUuN0LD50rOc0g" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" visible="1" canBeVaried="1" value="10" displayUnit="cm/min" />
-                    <Parameter id="vl_7HD4tFUKvjbWwlm9lkg" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Bon9EHArSU6bcCi8KdWj7w" visible="1" canBeVaried="1" />
-                    <Transport id="Z65115Ff4UmBsaA2s2iw5A" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Transport" dimension="Amount per time" formula="BNgpLNhrz0WB7mHOSWrWPA" sourceAmount="FRvVMGhi8UOBMOTbm5lolA" targetAmount="YMmIlmXRvkKumHoleo8cVg" />
-                  </Children>
-                </Container>
-                <Parameter id="aal8OrhigEeQgGCDqzUYRQ" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="M1mL5GdHW0W2i4shHC3aHA" visible="1" canBeVaried="1" displayUnit="cm²" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="NC9kuNGdvEey_a5-uV6Z3A" name="Skin_bc_VenousBlood_bc" description="Neighborhood between Skin/Blood Cells and Venous Blood/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="4S7otm2HZU6QSl2UbAf8-Q" secondNeighbor="HLhY21FI2UuJWgRMTu6RlA">
-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="GbO9fF7X60uAAFa_Hu_JHg" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="eYvG-RhP0kW4tbbOZ50M4A" name="MassTransferOrgRBC2BloodPool" description="Mass transfer from organ: Blood Cells to Arterial Blood: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="NmTGjYXhZUWK94jqbAlSfA" sourceAmount="DhjTerwdiEag5vbskJtPZw" targetAmount="GWJuEfO1Xkqh3wAfzsLyqQ" />
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-                <Tag value="Neighborhood: Plasma / Plasma" />
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-              <Children>
-                <Container id="Lixv0DYqLkiBphZ056ubKw" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="BB7gAX2wAkKxuPxt4oV78Q" name="MassTransferOrgPl2BloodPool_pve" description="Mass transfer from organ: Plasma to Portal Vein: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="JBB1-q_fDk-dbderQ0ANKg" sourceAmount="89VKmmFVs0qTmpo4TCEX_A" targetAmount="hqBDuJ9j9Eqjy73I0KZSUA" />
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-              <Tags>
-                <Tag value="Neighborhood: Interstitial / Intracellular" />
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-              <Children>
-                <Container id="Ha1Xocf6JEygkEfj2bMtLA" name="C1" mode="Logical" containerType="Molecule">
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-                    <Parameter id="dbIJUG3wikeREf15ga_nTg" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                    <Parameter id="W2Acd_l5lUuGH5aYRnfm3g" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="BtYHf38KbE2Woag0S8zVQw" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                    <Parameter id="lqPZahGLzkuvvLibYrBVkw" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="Y5i-HZk9NUeoA7UKGgQIDg" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                    <Parameter id="5pS3MJi_mEOpw1IXGb9lvA" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="hKXq5MVtGkCKHD0_pgT1Kg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="i5yroptLiEGD7GAwkwebsQ" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                    <Parameter id="WKSuqctTUkyK8Rvhn8bX4Q" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="kbWi1ECVpUm3aV2vTdzJEg" visible="1" canBeVaried="1" />
-                    <Parameter id="049FLWlMs0CrBdWkuA3Mbw" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="X8aa6JXQB0-b6a-LH5_Krw" visible="0" canBeVaried="1" />
-                    <Parameter id="BOHdys0rfE-WEh58ES-6Xw" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="p_bsa76dkkG6bsceP87FTg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="1T9dQSf2ikGNuiYyUpiKSg" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IL5MXjXgLk2jO2k-1hBbAw" visible="0" canBeVaried="0" />
-                    <Transport id="dM0tD7iIjUCoTiiEZMe-9Q" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Transport" dimension="Amount per time" formula="eg7LEKn1bUePg8fONNkChQ" sourceAmount="jGmdRn7IvUWvE6up89F5fA" targetAmount="uT-Gy4pavEOdkOTam6GdRw" />
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-                <Parameter id="YD0XmkKO1UeM1Uiq25lriA" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="_86hgyJcdkiPr06wyJujdg" visible="1" canBeVaried="1" displayUnit="cm²" />
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-              <Tags>
-                <Tag value="Neighborhood: Plasma / Interstitial" />
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-              <Children>
-                <Container id="fGx_We3iWk-orpG4AZcOUw" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="DMM7fy-zuECmEdS-bpl6JQ" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" visible="1" canBeVaried="1" value="10" displayUnit="cm/min" />
-                    <Parameter id="5-2tdLIfnEKcHg4y0IYAYw" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Bon9EHArSU6bcCi8KdWj7w" visible="1" canBeVaried="1" />
-                    <Transport id="ssjUF3hZw0-zUZG0m3hK3A" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Transport" dimension="Amount per time" formula="kG9OTdD08E2ZTMDEUQelzg" sourceAmount="89VKmmFVs0qTmpo4TCEX_A" targetAmount="jGmdRn7IvUWvE6up89F5fA" />
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-                <Parameter id="YptupisAt0G2cw-2VOsiLA" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="uTlueDKN2EqTKC3cGgUoHQ" visible="1" canBeVaried="1" displayUnit="cm²" />
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-            <Neighborhood id="ijzpH6cFHUaITNYZMroQhA" name="Spleen_pls_Spleen_bc" description="Neighborhood between Spleen/Plasma and Spleen/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="se5WEELXjEOw38dYu8tSjg" secondNeighbor="ynfwPF5DH0CK-Pig1QT3GQ">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / BloodCells" />
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-              <Children>
-                <Container id="wRPkZPB6e02yjnnskuTbfg" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="3TZgmWlWVEGmqSZzFYHVWw" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="HcDh4w31fEWZxzPUwqhn1Q" sourceAmount="89VKmmFVs0qTmpo4TCEX_A" targetAmount="gFh2BN_Bg0uEOyNf12mJCg" />
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-                </Container>
-                <Parameter id="aXo3ZU_ejEqJSrDti1IATA" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="43EB2-JS8EW0NK7Wa51Dng" visible="1" canBeVaried="1" displayUnit="cm²" />
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-                <Tag value="Neighborhood: BloodCells / BloodCells" />
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-              <Children>
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-                    <Transport id="wHakoGyprUe4kXChGovswA" name="MassTransferOrgRBC2BloodPool_Pve" description="Mass transfer from organ: Blood Cells to Portal Vein: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="gmqNhP8Du06hFK8GHEpePw" sourceAmount="gFh2BN_Bg0uEOyNf12mJCg" targetAmount="3A4PxVITtUOpr85RBMQZlg" />
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-              <Tags>
-                <Tag value="Neighborhood: SalivaGland / Saliva" />
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-              <Children>
-                <Container id="mED1_FmN80S8cFrg902EFw" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="eJPJU_B1pEKqZMAvZ8jyOA" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="_tZkvkYhQkeS2qL0X6L46A" visible="1" canBeVaried="1" />
-                    <Parameter id="DAyN3REtlUW3dyVSGzodxQ" name="SalivaPlasmaRatio" description="Ratio of saliva vs. plasma concentrations" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="0ZaLB3F56E-ERGuDy2gv3g" visible="0" canBeVaried="1" />
-                    <Transport id="2GWUP4Dsz0yA-1rdokD8rw" name="PassiveDiffusionPlsToSaliva" description="Passive diffusion plasma to saliva" mode="Logical" containerType="Transport" dimension="Amount per time" formula="vnpyBxIz9EelDNjp7A9xhg" sourceAmount="3GZVTxNM8k2EaLg6W5PP7Q" targetAmount="s0odon9lsEyxtZEzSSHy_w" />
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-            <Neighborhood id="TOH87HV0VU64GPNPk61oGA" name="Duodenum_pls_Duodenum_bc" description="Neighborhood between Small Intestine/Mucosa/Duodenum/Plasma and Small Intestine/Mucosa/Duodenum/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="5qa_dNfzPEqENSftAboAkA" secondNeighbor="TdV1_un1aESakxFEr6GkQw">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / BloodCells" />
-                <Tag value="Small intestine  neighborhood" />
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-              <Children>
-                <Container id="QqzH56e9C0KZLappVOtWxA" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="PGahojgWqEK877wnfRxYxA" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="UXMsfhjPN0eWUJ8dJNi9iA" sourceAmount="9U0qncgJp0GzhMN51sFuvg" targetAmount="F5meuBt0ck6H-U7fLJ-DUg" />
-                  </Children>
-                </Container>
-                <Parameter id="szVAwpFkukePM0YMkr_rew" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="Rqxek59BiE2CtB_Khatz4A" visible="1" canBeVaried="1" displayUnit="cm²" />
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-              <Tags>
-                <Tag value="Neighborhood: Plasma / Interstitial" />
-                <Tag value="Small intestine  neighborhood" />
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-              <Children>
-                <Container id="LmgcxDYiFU64hSAk-mTCcg" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="Z6wE6OCuoEmvNXuySajTCw" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" visible="1" canBeVaried="1" value="10" displayUnit="cm/min" />
-                    <Parameter id="iQwrCL5TsUi6Y1Lnf0UyiQ" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Bon9EHArSU6bcCi8KdWj7w" visible="1" canBeVaried="1" />
-                    <Transport id="6EI1FxhKCU693Kjyf0d8eQ" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Transport" dimension="Amount per time" formula="5LYZACEZ90u9jtG96Qs05w" sourceAmount="9U0qncgJp0GzhMN51sFuvg" targetAmount="fg-dyqp9w0KRdVpmwPAxnw" />
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-                <Parameter id="b2sj4ujg2UOWpIQXowVFAw" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="c_uatpZrbkikdzAX_DO-7A" visible="1" canBeVaried="1" displayUnit="cm²" />
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-              <Tags>
-                <Tag value="Neighborhood: Interstitial / Intracellular" />
-                <Tag value="Small intestine  neighborhood" />
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-              <Children>
-                <Container id="dvJJP84mNEqpvlW8iPyEGg" name="C1" mode="Logical" containerType="Molecule">
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-                    <Parameter id="KLKLU279RUSJUCtfu8rmZQ" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="bJbZb-9p3kqSAc1KeNNhWw" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                    <Parameter id="LP7n_bpYkU6MCkWZgZIk3A" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                    <Parameter id="Kwdfe-MhzUWrwGY1e-PkHg" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="vgwo_xJHp0GNTPXmQzSJnQ" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                    <Parameter id="nWccLN3KS0SjQafCw-c6_w" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="p_bsa76dkkG6bsceP87FTg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="omAnIXfpyUe9tjvCNguZqg" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                    <Parameter id="4m7YDm2z40icYteMlfPB6g" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="2AQgT6fBhUa0l8Nncq2aZw" visible="1" canBeVaried="1" />
-                    <Parameter id="4NyiNPvtvE27V6kWAzcxJQ" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="X8aa6JXQB0-b6a-LH5_Krw" visible="0" canBeVaried="1" />
-                    <Parameter id="H1WJCRjn7kai9n_2c5f_EA" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="hKXq5MVtGkCKHD0_pgT1Kg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="gS3tBWjiBke5uSHnaaLb6w" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="lu4zUH9xWUeBUaDg04lGug" visible="0" canBeVaried="0" />
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-                <Parameter id="E8v3L4RJ00qb8iEzTTWxhw" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="TLFuRtl7MEuoKmQ0uic8yw" visible="1" canBeVaried="1" displayUnit="cm²" />
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-              <Tags>
-                <Tag value="Neighborhood: Interstitial / Intracellular" />
-                <Tag value="Small intestine  neighborhood" />
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-              <Children>
-                <Container id="f7cuok_mW0WJw92BOmSsYg" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="uGHE5izeo0S9DVQH0Owcqw" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="X8aa6JXQB0-b6a-LH5_Krw" visible="0" canBeVaried="1" />
-                    <Parameter id="64XVXjtTTECLEU9JFfZJxg" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="bJbZb-9p3kqSAc1KeNNhWw" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                    <Parameter id="ff_8ufbHXkSLGEO9HGlQzg" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="vgwo_xJHp0GNTPXmQzSJnQ" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                    <Parameter id="vIST2G5fCU6zh0tkn2Y3RQ" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="hKXq5MVtGkCKHD0_pgT1Kg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="TAlHZoI0F06XRbDITJIjnA" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="p_bsa76dkkG6bsceP87FTg" visible="0" canBeVaried="1" displayUnit="l/min" />
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-                    <Parameter id="9E_jy-LwREiuRPWDla9x4Q" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="af2PCPDOyEuAqR-ooIg-Rw" visible="1" canBeVaried="1" />
-                    <Parameter id="aRAzymkbrUu__X0s_D9FJA" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                    <Parameter id="fAdnl-4MHEKBlnLN990DLQ" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="lu4zUH9xWUeBUaDg04lGug" visible="0" canBeVaried="0" />
-                    <Transport id="TsbIesFXh0KLF9YrP-ZfLw" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Transport" dimension="Amount per time" formula="UwYSkIi9-02sE0Qv0EaZBA" sourceAmount="OOb7YsEfk02jfdRenZxbbA" targetAmount="zqzRvmsGnUGFDX4cd4aGFQ" />
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-                <Parameter id="7YtudtX0mUuI6uS0hLVbeg" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="7Qj6cdr81UeapNy4Goj2oA" visible="1" canBeVaried="1" displayUnit="cm²" />
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-              <Tags>
-                <Tag value="Neighborhood: Plasma / BloodCells" />
-                <Tag value="Small intestine  neighborhood" />
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-              <Children>
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-                    <Transport id="bQnMk_tZ_0mjD6GRuWnNLQ" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="G8D7Ul9z1UaVQE1zrhNysQ" sourceAmount="PMNegnlhr0CXVnvfwhXU7g" targetAmount="RgAh2V1O4EKEVX6UAhe4zQ" />
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-              <Tags>
-                <Tag value="Neighborhood: Plasma / Interstitial" />
-                <Tag value="Small intestine  neighborhood" />
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-                <Tag value="Small intestine  neighborhood" />
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-                    <Parameter id="mNgemKJGAkGXL0yeKlQwrQ" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DWIBx0rWmkO7szFTT9IFEw" visible="1" canBeVaried="1" />
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-                <Tag value="Small intestine  neighborhood" />
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-                <Tag value="Small intestine  neighborhood" />
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-                <Tag value="Small intestine  neighborhood" />
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-                <Tag value="Small intestine  neighborhood" />
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-                    <Parameter id="Aj-5zlLfrU6-k5TJJcH2fQ" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
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-                    <Parameter id="04-kv9nYtEqWdIgyttW63g" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="X8aa6JXQB0-b6a-LH5_Krw" visible="0" canBeVaried="1" />
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-                    <Parameter id="qmEUJBjKAU-1ohInhuBwqQ" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="lu4zUH9xWUeBUaDg04lGug" visible="0" canBeVaried="0" />
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-            <Neighborhood id="xA7sUm8Y4U2Uh8yw-Dqd2A" name="LowerIleum_pls_LowerIleum_int" description="Neighborhood between Small Intestine/Mucosa/Lower Ileum/Plasma and Small Intestine/Mucosa/Lower Ileum/Interstitial" mode="Logical" containerType="Other" firstNeighbor="rrdHQQGA002quyiJj14SNw" secondNeighbor="uqiskikve0-qI31H7jOgWg">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Interstitial" />
-                <Tag value="Small intestine  neighborhood" />
-              </Tags>
-              <Children>
-                <Container id="9oLQD8wRyUeqCHYDqHru1Q" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="NQbNxr0Ob0mBjxMkBxAfnw" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Bon9EHArSU6bcCi8KdWj7w" visible="1" canBeVaried="1" />
-                    <Parameter id="_kHjAd0aZU2v78KNm03PwQ" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" visible="1" canBeVaried="1" value="10" displayUnit="cm/min" />
-                    <Transport id="lZDsRyhiBkaygtEDy8SvqQ" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Transport" dimension="Amount per time" formula="JUTH36hTGkiieegocH7dsg" sourceAmount="0cutZov5eEiqqp_uiBzdtw" targetAmount="RRkRhMuE70C8xM04dgNTkw" />
-                  </Children>
-                </Container>
-                <Parameter id="52FvDVt11EKLIhiXVEApmA" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="FRB1FqPXekmGqXsSXU_07Q" visible="1" canBeVaried="1" displayUnit="cm²" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="BAmrgR49b0W6lPGK-c-9pw" name="Caecum_pls_Caecum_int" description="Neighborhood between Large Intestine/Mucosa/Cecum/Plasma and Large Intestine/Mucosa/Cecum/Interstitial" mode="Logical" containerType="Other" firstNeighbor="qk0qF8uZI06cnoMMMXTreA" secondNeighbor="3hhWlW8CU02dQMHm8E1PTg">
-              <Tags>
-                <Tag value="Large intestine  neighborhood" />
-                <Tag value="Neighborhood: Plasma / Interstitial" />
-              </Tags>
-              <Children>
-                <Container id="kRwz8nXr5UGnDBnE1K0N0A" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="IYvFlb4w7EShkWzRepLwgg" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" visible="1" canBeVaried="1" value="10" displayUnit="cm/min" />
-                    <Parameter id="vSgRG4MLIUaByV90OoOCcA" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Bon9EHArSU6bcCi8KdWj7w" visible="1" canBeVaried="1" />
-                    <Transport id="YzsaebzPpk2gE6NFOUItog" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Transport" dimension="Amount per time" formula="_R9FOyo460mhUVWyGg9uTQ" sourceAmount="Lpte9WeV50K2AalO8MrxAw" targetAmount="CNB35o9wBEK0VIuxxircsA" />
-                  </Children>
-                </Container>
-                <Parameter id="kLUdpD-f1Uq-XSMoUIBbKw" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="9pry90whNE-NcT4Ihka96g" visible="1" canBeVaried="1" displayUnit="cm²" />
-              </Children>
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-            <Neighborhood id="RMe7IjijCEqsE97prRggdA" name="Caecum_pls_Caecum_bc" description="Neighborhood between Large Intestine/Mucosa/Cecum/Plasma and Large Intestine/Mucosa/Cecum/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="qk0qF8uZI06cnoMMMXTreA" secondNeighbor="6kGZy_3g3U-NktadHdhW3Q">
-              <Tags>
-                <Tag value="Large intestine  neighborhood" />
-                <Tag value="Neighborhood: Plasma / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="M4wS-DP3YE6TNSR21I_uyw" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="rORaoAijvUWLnAuAVGrJbQ" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="-sIx7AtIqkqaxq2ogBoQHg" sourceAmount="Lpte9WeV50K2AalO8MrxAw" targetAmount="05yORl8O3EeGbBTdKhAhHA" />
-                  </Children>
-                </Container>
-                <Parameter id="GZOSW-SBKU6bX9EtgvN4Jw" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="CPjr8bMwj0mRUJjq2mq-9w" visible="1" canBeVaried="1" displayUnit="cm²" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="Mb7NnXOiUEqAKDLQ2pLflw" name="Caecum_int_Caecum_cell" description="Neighborhood between Large Intestine/Mucosa/Cecum/Interstitial and Large Intestine/Mucosa/Cecum/Intracellular" mode="Logical" containerType="Other" firstNeighbor="3hhWlW8CU02dQMHm8E1PTg" secondNeighbor="t-B68_pEAUyLs_Kjh2XotQ">
-              <Tags>
-                <Tag value="Large intestine  neighborhood" />
-                <Tag value="Neighborhood: Interstitial / Intracellular" />
-              </Tags>
-              <Children>
-                <Container id="wpBzQpyq5Um-f28F3RIjFg" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="ka4B9ngXiUCGefS32bvwVw" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="7GgvT6a2IkW_0KfC4Yta0Q" visible="1" canBeVaried="1" />
-                    <Parameter id="Xi_7pGkSPEqVfXtcwzgqMA" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="bJbZb-9p3kqSAc1KeNNhWw" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                    <Parameter id="6BGUC924hkaaWF1zxVnqbw" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="vgwo_xJHp0GNTPXmQzSJnQ" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                    <Parameter id="3NtKSshVsk-VLaPl9p83Eg" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="hKXq5MVtGkCKHD0_pgT1Kg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="1A-pL-3xakqTg5fkjMDxbg" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="p_bsa76dkkG6bsceP87FTg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="MsvZ-tAPPkibAzPGFE5oxA" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                    <Parameter id="t53XDrqaJkyiD4mGXMmytQ" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="X8aa6JXQB0-b6a-LH5_Krw" visible="0" canBeVaried="1" />
-                    <Parameter id="YyNRv0dcHUWGuF_1klGSZg" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                    <Parameter id="ex-o7OjFz0-RL-kpkuqtAA" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="2iaBngQgI0qH_r5qEaH-Vg" visible="0" canBeVaried="0" />
-                    <Transport id="qwsR_M1AUkyD0MDHU-epDg" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Transport" dimension="Amount per time" formula="mtPEUK_dbE6iNkWm4uEeQw" sourceAmount="CNB35o9wBEK0VIuxxircsA" targetAmount="gaxUc91cjECJ7Oyx20_0iw" />
-                  </Children>
-                </Container>
-                <Parameter id="qA1720C4hEW949l4YlwV_w" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="5trqedDlfkySq7eU1B2QMQ" visible="1" canBeVaried="1" displayUnit="cm²" />
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-            <Neighborhood id="dc3XVtqg5EC7wtCpCF3DBg" name="ColonAscendens_pls_ColonAscendens_bc" description="Neighborhood between Large Intestine/Mucosa/Colon Ascendens/Plasma and Large Intestine/Mucosa/Colon Ascendens/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="Aivr7qttHUatCWB0Vus_ew" secondNeighbor="-BbZRBaQ_EGB3LiH3qZ_Ag">
-              <Tags>
-                <Tag value="Large intestine  neighborhood" />
-                <Tag value="Neighborhood: Plasma / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="BtzIkpWIC0WsBNqCOkuMQg" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="CqQUSDrRVEWF4kB5FMM8pg" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="f6eHAcllekKlkrSYUWMYsA" sourceAmount="0zNjwXhGpkSaSYQZC4yzdw" targetAmount="Ls0R4hvRKki76eHKnnDq6g" />
-                  </Children>
-                </Container>
-                <Parameter id="W8z_HAl6ekmGBRfTciL7iA" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="VT5DQZ3NcUeHilY7GtTwaQ" visible="1" canBeVaried="1" displayUnit="cm²" />
-              </Children>
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-              <Tags>
-                <Tag value="Large intestine  neighborhood" />
-                <Tag value="Neighborhood: Interstitial / Intracellular" />
-              </Tags>
-              <Children>
-                <Container id="KD5IIujHp0mF1JHQ-9yT1Q" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="MExfM5CnTU-zcMHUGb8_uw" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="bJbZb-9p3kqSAc1KeNNhWw" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                    <Parameter id="7w1BulneH0ah2rOhRdJfGg" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="vgwo_xJHp0GNTPXmQzSJnQ" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                    <Parameter id="Ic175MrTeUmT3iYljbRsiQ" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="hKXq5MVtGkCKHD0_pgT1Kg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="8HaH9hkf-kOleRtSrLQ20g" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="p_bsa76dkkG6bsceP87FTg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="-xWEh5v9iUCe-fACUgSnLw" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                    <Parameter id="tqdIn9C5VEySOLyvSRQ2Vg" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                    <Parameter id="NgFnmnbLd0-dymzGs5fFCg" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="ClhQNwQFCUqP-su5M8WzEg" visible="1" canBeVaried="1" />
-                    <Parameter id="iSmyL3ZIHU-bndgBlKmmcA" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="X8aa6JXQB0-b6a-LH5_Krw" visible="0" canBeVaried="1" />
-                    <Parameter id="Elm9fv4C_027c7ihiUFrlQ" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="2iaBngQgI0qH_r5qEaH-Vg" visible="0" canBeVaried="0" />
-                    <Transport id="HWHBkM1xoka93OOwlWVCGQ" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Transport" dimension="Amount per time" formula="iVs-dDr7IUyF0qjJHnM7ZA" sourceAmount="9bgCoeKsLkKvhkx6FdY3iQ" targetAmount="Y5D_k9113E2RRgqowuESsw" />
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-                </Container>
-                <Parameter id="UAa_BsyqHkOADwLBHw4JiA" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="uiMNQfq840OK_Ycg_f_srQ" visible="1" canBeVaried="1" displayUnit="cm²" />
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-              <Tags>
-                <Tag value="Large intestine  neighborhood" />
-                <Tag value="Neighborhood: Plasma / Interstitial" />
-              </Tags>
-              <Children>
-                <Container id="gX9UFrTSXEavfWtGNosaOw" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="7qs7Q5Cmq0KhayKqpwEuoA" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" visible="1" canBeVaried="1" value="10" displayUnit="cm/min" />
-                    <Parameter id="FhBq2gwhkUWyQdaWgruToQ" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Bon9EHArSU6bcCi8KdWj7w" visible="1" canBeVaried="1" />
-                    <Transport id="ryE0_k6BL0muxWc_QPz2-A" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Transport" dimension="Amount per time" formula="rxD-LCUKQUuBOErJlbxCYQ" sourceAmount="0zNjwXhGpkSaSYQZC4yzdw" targetAmount="9bgCoeKsLkKvhkx6FdY3iQ" />
-                  </Children>
-                </Container>
-                <Parameter id="DIPf5pxUyU6znG5KI4JRLQ" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="MX66-yfiZEeA0Puo9AgwXg" visible="1" canBeVaried="1" displayUnit="cm²" />
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-            </Neighborhood>
-            <Neighborhood id="sb5CSfd7MEmRLCjN-_5WPg" name="ColonTransversum_int_ColonTransversum_cell" description="Neighborhood between Large Intestine/Mucosa/Colon Transversum/Interstitial and Large Intestine/Mucosa/Colon Transversum/Intracellular" mode="Logical" containerType="Other" firstNeighbor="uSnfTCjzEEKsrn-SJCCw0g" secondNeighbor="bQfRvdb_CEakRfpxkmjp1g">
-              <Tags>
-                <Tag value="Large intestine  neighborhood" />
-                <Tag value="Neighborhood: Interstitial / Intracellular" />
-              </Tags>
-              <Children>
-                <Container id="Mhxy7FPr4Eyz4at_XqXZwQ" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="QF_nY5fNR0Snd4psMTj1mw" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="bJbZb-9p3kqSAc1KeNNhWw" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                    <Parameter id="dn1S8ggwpEOGRRJQNpi-yg" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="vgwo_xJHp0GNTPXmQzSJnQ" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                    <Parameter id="d4_CLHlDSUeULGvQQJhLfw" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="hKXq5MVtGkCKHD0_pgT1Kg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="VaLxaS2h30uffLLjdIp0NA" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="p_bsa76dkkG6bsceP87FTg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="d4kttql4DkCWxYBkgF-vbw" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                    <Parameter id="UGIzSjTB2UKqXnaC6frIeQ" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                    <Parameter id="_UD0EugXaUaPzydAVlaRqQ" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="J75nWmI5QUCkFTXN4HaYYg" visible="1" canBeVaried="1" />
-                    <Parameter id="kMKyusRrHEuJS2_YMpFfgg" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="X8aa6JXQB0-b6a-LH5_Krw" visible="0" canBeVaried="1" />
-                    <Parameter id="0Tzq2d7ydkCo2OUVAo0zhQ" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="2iaBngQgI0qH_r5qEaH-Vg" visible="0" canBeVaried="0" />
-                    <Transport id="L1p8pIwatUmy4Bm6sQux2g" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Transport" dimension="Amount per time" formula="v5-a-KBxhkiIHNva5Xn8yw" sourceAmount="8b6AM8coN0GCBiF054tGIw" targetAmount="H0qyxGwyUkWmeHAlvjEj4w" />
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-                <Parameter id="BtdIGOv7FkeGX8wjx7ht9Q" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="zrSgjN6zGUipvCNXPcTmdw" visible="1" canBeVaried="1" displayUnit="cm²" />
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-            <Neighborhood id="fe-t4gNlck-lgPLb4YrzTg" name="ColonTransversum_pls_ColonTransversum_bc" description="Neighborhood between Large Intestine/Mucosa/Colon Transversum/Plasma and Large Intestine/Mucosa/Colon Transversum/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="-P41WVvf4kGpY92ttsK8NQ" secondNeighbor="nK4V9tiRUUy-zjLhRo56OA">
-              <Tags>
-                <Tag value="Large intestine  neighborhood" />
-                <Tag value="Neighborhood: Plasma / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="XvtstZf4VUiYXr2DtllhmQ" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="80_Gdp2J-0ysPmleWsoUFw" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="EBXbpTeky02u-j9Mj-bwZQ" sourceAmount="bnMs2biCD0u9uVZoaq3RZQ" targetAmount="2BQp7lKGjkCgjUSXvOs6QQ" />
-                  </Children>
-                </Container>
-                <Parameter id="T9EL0yWXTEatYx9UiKZiEQ" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="atvRRRkiq0Sbi1OjqJYtrA" visible="1" canBeVaried="1" displayUnit="cm²" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="wWMM3VwRG0OFLfnvuBy1ZA" name="ColonTransversum_pls_ColonTransversum_int" description="Neighborhood between Large Intestine/Mucosa/Colon Transversum/Plasma and Large Intestine/Mucosa/Colon Transversum/Interstitial" mode="Logical" containerType="Other" firstNeighbor="-P41WVvf4kGpY92ttsK8NQ" secondNeighbor="uSnfTCjzEEKsrn-SJCCw0g">
-              <Tags>
-                <Tag value="Large intestine  neighborhood" />
-                <Tag value="Neighborhood: Plasma / Interstitial" />
-              </Tags>
-              <Children>
-                <Container id="9OsSIpUsW021qtK2S-FH3A" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="vy_1NZu1P0a9Y1gIVWynYQ" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" visible="1" canBeVaried="1" value="10" displayUnit="cm/min" />
-                    <Parameter id="4l89G7Qh8kyIpI4hDAJFOg" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Bon9EHArSU6bcCi8KdWj7w" visible="1" canBeVaried="1" />
-                    <Transport id="gs6W62lFBUqYd2P7RAtyaQ" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Transport" dimension="Amount per time" formula="USghaOHBhUCTWl1nlEEmIQ" sourceAmount="bnMs2biCD0u9uVZoaq3RZQ" targetAmount="8b6AM8coN0GCBiF054tGIw" />
-                  </Children>
-                </Container>
-                <Parameter id="QXMntk-GHU2iXztdu09D1A" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="7ZaoSmpvWUiat7CThixiHg" visible="1" canBeVaried="1" displayUnit="cm²" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="SeSEpPiX8k-NoPbQtEuaqA" name="ColonDescendens_pls_ColonDescendens_int" description="Neighborhood between Large Intestine/Mucosa/Colon Descendens/Plasma and Large Intestine/Mucosa/Colon Descendens/Interstitial" mode="Logical" containerType="Other" firstNeighbor="IYSOBD2MW0SByEccir1gtg" secondNeighbor="YUV1KDlDvUS4N8X86jTR_w">
-              <Tags>
-                <Tag value="Large intestine  neighborhood" />
-                <Tag value="Neighborhood: Plasma / Interstitial" />
-              </Tags>
-              <Children>
-                <Container id="P3IxqnFna0mqD_v6uWy2ag" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="Rkn1QOHRfUuKMz4vzH5VUA" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" visible="1" canBeVaried="1" value="10" displayUnit="cm/min" />
-                    <Parameter id="sYsR_xzCwUCKIkYUWQduqQ" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Bon9EHArSU6bcCi8KdWj7w" visible="1" canBeVaried="1" />
-                    <Transport id="66Dlc5aKIUOaRvWXQySpfQ" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Transport" dimension="Amount per time" formula="Akx04NXOx0aV-E2FNakqWw" sourceAmount="fRScY5akTkSbcR1hbKcs5Q" targetAmount="OTfVa-Dmd029ivqi8nkVCQ" />
-                  </Children>
-                </Container>
-                <Parameter id="UFML_fAl3EqHeV2uUGZo1A" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="F0K0gsB_lUGKtlom-fCBBg" visible="1" canBeVaried="1" displayUnit="cm²" />
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-            <Neighborhood id="BL48pePMz0yvX7i5pP5q6g" name="ColonDescendens_pls_ColonDescendens_bc" description="Neighborhood between Large Intestine/Mucosa/Colon Descendens/Plasma and Large Intestine/Mucosa/Colon Descendens/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="IYSOBD2MW0SByEccir1gtg" secondNeighbor="0Ysv4senlEeNmmozTIAQkw">
-              <Tags>
-                <Tag value="Large intestine  neighborhood" />
-                <Tag value="Neighborhood: Plasma / BloodCells" />
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-              <Children>
-                <Container id="IPo_MNDWUkO0IcapdxkAqA" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="CXGvCaD3Tk-0in0d5iF75Q" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="BqIYDin2A0qQzsIcjPd7Kw" sourceAmount="fRScY5akTkSbcR1hbKcs5Q" targetAmount="3eMVtSbfykKuZmsiS31jUg" />
-                  </Children>
-                </Container>
-                <Parameter id="r_hgqFcADEGIUEvnZS9IWg" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="JMGeqBqNPkK_L8wXIgo4Kg" visible="1" canBeVaried="1" displayUnit="cm²" />
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-            <Neighborhood id="HwSKYTfqU0O8Uut94qRBRw" name="ColonDescendens_int_ColonDescendens_cell" description="Neighborhood between Large Intestine/Mucosa/Colon Descendens/Interstitial and Large Intestine/Mucosa/Colon Descendens/Intracellular" mode="Logical" containerType="Other" firstNeighbor="YUV1KDlDvUS4N8X86jTR_w" secondNeighbor="yvx9mFVur0KdwvcmwHHcQw">
-              <Tags>
-                <Tag value="Large intestine  neighborhood" />
-                <Tag value="Neighborhood: Interstitial / Intracellular" />
-              </Tags>
-              <Children>
-                <Container id="J8m2edZEZEeCkWtbQ1LIMQ" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="35Cq-_uJG0iJzrlDtbj2aA" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="vgwo_xJHp0GNTPXmQzSJnQ" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                    <Parameter id="Q3htQ7JnjUyqEodK2sAnwQ" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="bJbZb-9p3kqSAc1KeNNhWw" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                    <Parameter id="bDVdPapLfk2NPqTaYyipYQ" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="hKXq5MVtGkCKHD0_pgT1Kg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="7xre57gjikmTGoNrKNLPvQ" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                    <Parameter id="pPPk4kl0Z06LSgt6tngOug" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="p_bsa76dkkG6bsceP87FTg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="mcDl7gcX006pvVU5Fdf0zA" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                    <Parameter id="aTQylJoFhE-GYP0XtIKJWQ" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="N17eBDRd7UmnoqYXzA5PVw" visible="1" canBeVaried="1" />
-                    <Parameter id="wUEBfig6OUuQKf66bmodVw" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="X8aa6JXQB0-b6a-LH5_Krw" visible="0" canBeVaried="1" />
-                    <Parameter id="s1kgDDnnokS30Di-q_LRjA" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="2iaBngQgI0qH_r5qEaH-Vg" visible="0" canBeVaried="0" />
-                    <Transport id="JXKFq1SGxUSz2I3s9I8U7Q" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Transport" dimension="Amount per time" formula="tiyKbbGO-U2XdFs0TxBmzg" sourceAmount="OTfVa-Dmd029ivqi8nkVCQ" targetAmount="XdsPQQqfnU68je9V8z203Q" />
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-                </Container>
-                <Parameter id="13qMYGpYZ0Kgy9wYS2Rulg" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="2dg-EovpUU6e7Z3g45MndQ" visible="1" canBeVaried="1" displayUnit="cm²" />
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-            <Neighborhood id="7_fH9poPzEGyxUoIlWgD8A" name="ColonSigmoid_pls_ColonSigmoid_int" description="Neighborhood between Large Intestine/Mucosa/Colon Sigmoid/Plasma and Large Intestine/Mucosa/Colon Sigmoid/Interstitial" mode="Logical" containerType="Other" firstNeighbor="bzYLFyk2JkmtP6F5xOz6QQ" secondNeighbor="5HpeQ-ekKkOS2la6bazFiA">
-              <Tags>
-                <Tag value="Large intestine  neighborhood" />
-                <Tag value="Neighborhood: Plasma / Interstitial" />
-              </Tags>
-              <Children>
-                <Container id="150VofmSukmfnxt3-O1Pqw" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="6J5VVbSKyUqUy2b8KmTKRA" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" visible="1" canBeVaried="1" value="10" displayUnit="cm/min" />
-                    <Parameter id="CyY8N7iWG0mnzdEtEwl6WQ" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Bon9EHArSU6bcCi8KdWj7w" visible="1" canBeVaried="1" />
-                    <Transport id="-8yyLK51KkWQn0O0zCJYqQ" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Transport" dimension="Amount per time" formula="aJq-OW2VY0uHlO7fjJMZqw" sourceAmount="xTGJR_rEKE6vG1pK_dnKhA" targetAmount="EoUr17TiR061xnfZLxGy_A" />
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-                </Container>
-                <Parameter id="HCQCEBFxGEi_q-xCeG4Jlw" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="iE8AatseKkGicKiY4Aldqw" visible="1" canBeVaried="1" displayUnit="cm²" />
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-            <Neighborhood id="7mbX_Ps8AUWind_3-xZdBQ" name="ColonSigmoid_pls_ColonSigmoid_bc" description="Neighborhood between Large Intestine/Mucosa/Colon Sigmoid/Plasma and Large Intestine/Mucosa/Colon Sigmoid/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="bzYLFyk2JkmtP6F5xOz6QQ" secondNeighbor="96RIWxzJSUmdHw6J1qxOyw">
-              <Tags>
-                <Tag value="Large intestine  neighborhood" />
-                <Tag value="Neighborhood: Plasma / BloodCells" />
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-              <Children>
-                <Container id="smYk603oqEezzxgy4fR2tQ" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="ZQYcvDbkVESqBsVfztsIYA" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="UAb3a98lPESDQjbjXUiVOg" sourceAmount="xTGJR_rEKE6vG1pK_dnKhA" targetAmount="nPc7HZ7onEeWVXA5yaAQVg" />
-                  </Children>
-                </Container>
-                <Parameter id="0wKAu4hG-E29i1SWJ7c97A" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="jysOqtClxEKyvTZFL-YxEQ" visible="1" canBeVaried="1" displayUnit="cm²" />
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-            <Neighborhood id="4_6zB1p8Jkur6ch8UIL3Uw" name="ColonSigmoid_int_ColonSigmoid_cell" description="Neighborhood between Large Intestine/Mucosa/Colon Sigmoid/Interstitial and Large Intestine/Mucosa/Colon Sigmoid/Intracellular" mode="Logical" containerType="Other" firstNeighbor="5HpeQ-ekKkOS2la6bazFiA" secondNeighbor="dEAYEXl0dk2Rv-tt0gU9NA">
-              <Tags>
-                <Tag value="Large intestine  neighborhood" />
-                <Tag value="Neighborhood: Interstitial / Intracellular" />
-              </Tags>
-              <Children>
-                <Container id="CwN_1uCkvEKJwJDVIW8pXQ" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="D5vt8lQxZEqTNAcX7JJjhA" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                    <Parameter id="CH5FKC4f50qPsKe1t9IAGw" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="VFP369WwLECg-GMu1EB3iQ" visible="1" canBeVaried="1" />
-                    <Parameter id="fXVkHsjjfkqtc_nf_Xkehw" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="X8aa6JXQB0-b6a-LH5_Krw" visible="0" canBeVaried="1" />
-                    <Parameter id="KA9mFci3fkaX8f767xHlGA" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                    <Parameter id="tL0048zYt0W78tYgMGbpLw" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="p_bsa76dkkG6bsceP87FTg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="cRc9oDhv_UamG-pd9fihYA" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="hKXq5MVtGkCKHD0_pgT1Kg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="kH4fXcQNgkyUiDIbwVvY0g" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="vgwo_xJHp0GNTPXmQzSJnQ" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                    <Parameter id="DVeQYBTHd0SqF4Sa4bxN7w" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="bJbZb-9p3kqSAc1KeNNhWw" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                    <Parameter id="83kkkQ2G1Uma_tELOo-msQ" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="2iaBngQgI0qH_r5qEaH-Vg" visible="0" canBeVaried="0" />
-                    <Transport id="5G2jAak1U0CCcnrQux4Ppg" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Transport" dimension="Amount per time" formula="K4mopCtqy0CZiOurFKSr_A" sourceAmount="EoUr17TiR061xnfZLxGy_A" targetAmount="_FYwdcJVXUmHAbB3mDuZPw" />
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-                </Container>
-                <Parameter id="nI1ldxVJdUy70JGjkv6r9w" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="ArZGprDfO0ufFfbcioE3dQ" visible="1" canBeVaried="1" displayUnit="cm²" />
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-            <Neighborhood id="ygEjO4qct0602_AeMHMb0Q" name="Rectum_pls_Rectum_int" description="Neighborhood between Large Intestine/Mucosa/Rectum/Plasma and Large Intestine/Mucosa/Rectum/Interstitial" mode="Logical" containerType="Other" firstNeighbor="WMIBikKwrEe1vMFMiv-ong" secondNeighbor="k2lXslAcv0O9A3Owj-loLg">
-              <Tags>
-                <Tag value="Large intestine  neighborhood" />
-                <Tag value="Neighborhood: Plasma / Interstitial" />
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-              <Children>
-                <Container id="EtiFGWwoZUyR9LNMCcwSGQ" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="M485lTxCz0e19Nx7-tIhCA" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" visible="1" canBeVaried="1" value="10" displayUnit="cm/min" />
-                    <Parameter id="Nqf4Q1zDhUKjlDf297rtng" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Bon9EHArSU6bcCi8KdWj7w" visible="1" canBeVaried="1" />
-                    <Transport id="NUN20avVr0uavbPgSy81AA" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Transport" dimension="Amount per time" formula="RR7OlCU3gkeBr7qJByV_uA" sourceAmount="w16XRTEu1kCkEKI9PKRZEg" targetAmount="znbTFUnnCk6LEJuB7ZDqlg" />
-                  </Children>
-                </Container>
-                <Parameter id="F-RqMKOuEU22X9a7Ot3SkA" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="DgTtTYKZXES3KoKoaxjnMw" visible="1" canBeVaried="1" displayUnit="cm²" />
-              </Children>
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-            <Neighborhood id="Kd8XoDcl0kmLZl3qes3Qig" name="Rectum_pls_Rectum_bc" description="Neighborhood between Large Intestine/Mucosa/Rectum/Plasma and Large Intestine/Mucosa/Rectum/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="WMIBikKwrEe1vMFMiv-ong" secondNeighbor="XuC4VFLrok2cYGGvu6Zk6A">
-              <Tags>
-                <Tag value="Large intestine  neighborhood" />
-                <Tag value="Neighborhood: Plasma / BloodCells" />
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-              <Children>
-                <Container id="Oa0UzgPffkuiEr-0z5XyAg" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="MYR-QxLcWE6KQH8rUUPBRA" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="BgDDZfIVXESTNsAk6L79uA" sourceAmount="w16XRTEu1kCkEKI9PKRZEg" targetAmount="r0gwYEI_O0mcxiowmhPpKQ" />
-                  </Children>
-                </Container>
-                <Parameter id="oxihobFyukmUwFXThzTzaQ" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="-ow6f5deh0G2u42wAHXCRw" visible="1" canBeVaried="1" displayUnit="cm²" />
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-            </Neighborhood>
-            <Neighborhood id="huEYTUhc2U-lXMvKP7Nt5g" name="Rectum_int_Rectum_cell" description="Neighborhood between Large Intestine/Mucosa/Rectum/Interstitial and Large Intestine/Mucosa/Rectum/Intracellular" mode="Logical" containerType="Other" firstNeighbor="k2lXslAcv0O9A3Owj-loLg" secondNeighbor="xqyjpic_fU-nSEKNKkYMGw">
-              <Tags>
-                <Tag value="Large intestine  neighborhood" />
-                <Tag value="Neighborhood: Interstitial / Intracellular" />
-              </Tags>
-              <Children>
-                <Container id="qK_iCZSj4EiR2CM3fxQlmQ" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="gX5qZylBEU6G51HWwDqb7w" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="X8aa6JXQB0-b6a-LH5_Krw" visible="0" canBeVaried="1" />
-                    <Parameter id="yMERbQiEH0imi-bqd36B2g" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="bJbZb-9p3kqSAc1KeNNhWw" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                    <Parameter id="d0KOPO5hVkS7PyluIPhN0g" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="vgwo_xJHp0GNTPXmQzSJnQ" visible="1" canBeVaried="1" displayUnit="cm/min" />
-                    <Parameter id="2soScYOv3UO9ozTMtiRHFA" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="hKXq5MVtGkCKHD0_pgT1Kg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="QMFO2IwgxU-FefW9e893dQ" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" formula="p_bsa76dkkG6bsceP87FTg" visible="0" canBeVaried="1" displayUnit="l/min" />
-                    <Parameter id="FD766VbEAk-1phRtWVYehA" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                    <Parameter id="TVpgCtBHjEGd78twrzSWAA" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1" />
-                    <Parameter id="Cggbb1f_iE2My5DDcWheRA" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="injlmJ5hdU2NasbrBe_SPg" visible="1" canBeVaried="1" />
-                    <Parameter id="9NDnoRSE3EOalq__h1wpMw" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="2iaBngQgI0qH_r5qEaH-Vg" visible="0" canBeVaried="0" />
-                    <Transport id="fWu2Wcd4UkWT-8CbwZZZZA" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Transport" dimension="Amount per time" formula="TNHBU_S6kUyj541VF4FL9g" sourceAmount="znbTFUnnCk6LEJuB7ZDqlg" targetAmount="QVE4GWVZMEmvb2TwJk78sQ" />
-                  </Children>
-                </Container>
-                <Parameter id="7Yl_pW-Ck0OVS4Zw1gCIpQ" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" formula="Dhw5KfO2jUKF8MJtGG72ZA" visible="1" canBeVaried="1" displayUnit="cm²" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="e9XiNxmlNUq2Q993Qz-O7w" name="Caecum_bc_PortalVein_bc" description="Neighborhood between Cecum/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="6kGZy_3g3U-NktadHdhW3Q" secondNeighbor="V3IajphOTUWt3a2j9_LOZA">
-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="Pjq-Fqu3tECe9XGs1pTrKg" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="joS7tZ4vpECciqlL4sehyg" name="Mass transfer rate (mucosa to portal vein blood cells)" description="Mass transfer rate (mucosa to portal vein blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="hhgsXpSYWUCOcVpCJA2n1w" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Transport id="evDdCW1m50mgrtmtzpIKfg" name="MassTransferMucosaToPveBC" description="Mass transfer from Mucosa:Blood Cells To Portal Vein: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="JZvPFhHMhkKsX20YxpBGCg" sourceAmount="05yORl8O3EeGbBTdKhAhHA" targetAmount="3A4PxVITtUOpr85RBMQZlg" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="L-0o7OGb00ujmDg-fPhrUQ" name="Lumen_cae_Caecum_cell" description="Neighborhood between Lumen/Cecum and Mucosa/Cecum/Intracellular" mode="Logical" containerType="Other" firstNeighbor="jlQkJ9VHjEatlpKzMFmnlw" secondNeighbor="t-B68_pEAUyLs_Kjh2XotQ">
-              <Tags>
-                <Tag value="Neighborhood: Caecum / Intracellular" />
-              </Tags>
-              <Children>
-                <Container id="S_wbgg0RGkOdARH9E0g7og" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="tGzluZKWS0OrQlOu3jVh9g" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="aZYSS2yfyEqUEbGBDu38yg" visible="0" canBeVaried="0" />
-                    <Parameter id="4_7TRkLnk02ka2ARuuGL_w" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="Xa87YOIrCUuqk8AuzdyerQ" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="gZaaGJa1-k6sIdPcY_5yXw" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Zyv3Gbpf6Uqt5x3loUg14Q" visible="0" canBeVaried="0" />
-                    <Parameter id="9v4Uuwh7YEaAgk2pMaRMhA" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="bOPO_JT8sEOF6PITZSGGVg" visible="0" canBeVaried="0" />
-                    <Parameter id="rUNdlzQLQE2Sl7aeKlkJNw" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="tbdwwXyasUKgZTskMkVzsg" visible="0" canBeVaried="0" />
-                    <Parameter id="k8DLoMMYkUWrhQpjDsnlsg" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="ZYTb8QL8BEuzl-aXlSJ8QA" visible="0" canBeVaried="1" />
-                    <Parameter id="u38q7wHz2kK_FT-KPSliHg" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="m0r6nKhjfESJNoS_M4-1sA" visible="0" canBeVaried="0" />
-                    <Parameter id="rVPEvBm23E6HdmQHlraXFQ" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="ixCjsTfas0-ybrfchDiQIA" visible="0" canBeVaried="0" />
-                    <Parameter id="n7cACwidoE2WBRPUQvznTg" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="UrNk3ABKbkSezSCxq8IBJg" visible="0" canBeVaried="0" />
-                    <Parameter id="JTq-mTFFyEqh3B-UKNydJA" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="0IIh6FJV0UKyrimES0f1xg" visible="0" canBeVaried="0" />
-                    <Parameter id="hJ5UkSx-9kuwYDDKqw5dvQ" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="KQgllSQtqk2EfhX37WilDQ" visible="0" canBeVaried="0" />
-                    <Parameter id="TfOH2jradkm-SBoxRg-NpQ" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="7NEiCDSKM0i6GhEpoWb-Mw" visible="0" canBeVaried="0" />
-                    <Parameter id="zB281xHy1U6R9WeofYIB5Q" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="3xvkxp6qK06bn4DgEtYULA" visible="0" canBeVaried="0" />
-                    <Parameter id="-qg4Ir2YIU279In1k71Hiw" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="ezAHDPnckEKYf8L1jOtGfw" visible="0" canBeVaried="0" />
-                    <Parameter id="FQUpsFsqqk-t7GhGRLxPyA" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="2IVWcgM31UCSVl8zMDnDhw" visible="0" canBeVaried="0" />
-                    <Parameter id="GHSvqOhO2UWysgQMM9-VaQ" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DNGx_vFWp0KdOb7CGcoTLQ" visible="0" canBeVaried="0" />
-                    <Parameter id="qD7icWL6T020rr2n8yZt_w" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="YTMjQB_2qEq6Mt6HIde1Lw" visible="0" canBeVaried="0" />
-                    <Parameter id="ei9fqBCsUke-fCC3_WsXFA" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="XxrRGXjN7k2I9-W8stVfXg" visible="0" canBeVaried="0" />
-                    <Parameter id="yYXhtWYU9k-0GM3249H4Ig" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="PEhoVdLppU-G3xULjX_71g" visible="0" canBeVaried="0" />
-                    <Parameter id="yLoqBGjMQk-J1aW87pLL2w" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="pGvG5UNdC0Sot3_d3Qdvag" visible="0" canBeVaried="0" />
-                    <Parameter id="KVT8yor4kUaFXMq_DvWBHQ" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="jJfeJ2YxEki9TK9XP6uUMA" visible="0" canBeVaried="0" />
-                    <Parameter id="xGERggM8y0in8ZBFR9ylOg" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DNF0kWPUFk-rtSd0Ng1Mkw" visible="0" canBeVaried="0" />
-                    <Parameter id="I8Tj9BJrv02LONwa77cD7Q" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="gxoZyuApjEuzsuLtZuZWmQ" visible="0" canBeVaried="0" />
-                    <Parameter id="iYfitlMh5U-EKiMFAzOyRw" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="qr_x2cq_Y0C6Ur-VSCP4AQ" visible="0" canBeVaried="0" />
-                    <Parameter id="U1zZii-AKU20vya8S7qhHg" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Iph7YhQ5KUmsZWUX2Xf2Wg" visible="0" canBeVaried="0" />
-                    <Parameter id="u1oTrIuT6kCI_eprUbfpag" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="aWekJ2NVAECIIbxJKJ8L5g" visible="0" canBeVaried="0" />
-                    <Parameter id="M89Ahojlh0SEsnq-tcAvtg" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="zomQCqlsx02oSPohqFWyVw" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="JHcJAZPco0Cd0oX1tOkYTQ" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="1geuRzcMDU-pf7NzQveoTg" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="Yu_aqLbxtUC48cM9xkT0Sg" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="LcUCvhU3W0udtbpS1KVhEQ" visible="0" canBeVaried="0" />
-                    <Transport id="su5DKXtVVk2DkVcdekQp1g" name="DrugAbsorption_trans" description="Drug absorption transcellular" mode="Logical" containerType="Transport" dimension="Amount per time" formula="hHSsRDxF00iHAkNvfVwgBg" sourceAmount="Qnj6YM6q_kSvSvGmWycE8g" targetAmount="gaxUc91cjECJ7Oyx20_0iw">
-                      <Children>
-                        <Parameter id="x6gjvUUXlEKrJJLxdbimPQ" name="ProcessRate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="oGTujGMePUuYmwIIcDr6JQ" visible="0" canBeVaried="1" displayUnit="µmol/min">
-                          <Tags>
-                            <Tag value="DrugAbsorption_trans" />
-                            <Tag value="ProcessRate" />
-                            <Tag value="C1" />
-                            <Tag value="Lumen_cae_Caecum_cell" />
-                            <Tag value="Passive" />
-                          </Tags>
-                        </Parameter>
-                      </Children>
-                    </Transport>
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="8ZNnyppax0KaepVKDwKSGw" name="Lumen_cae_Caecum_pls" description="Neighborhood between Lumen/Cecum and Mucosa/Cecum/Plasma" mode="Logical" containerType="Other" firstNeighbor="jlQkJ9VHjEatlpKzMFmnlw" secondNeighbor="qk0qF8uZI06cnoMMMXTreA">
-              <Tags>
-                <Tag value="Neighborhood: Caecum / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="XDe_zZvc5Uy7QJEDJwQV2Q" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="ui6UpyC8ikuxCSezOcQA9w" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="iTPK465Nd0SSr9zsthfzeA" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="-eiIirM1mEyhgq1n5UehUw" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="sGLOiNpXX0eybYt6a7XWww" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="_2Vc9DjkjUS6eCED_r6cnA" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="ihXLA9rdTUy5EJFrCetUUg" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="bIRxzW_8ZkKpcEMbIl3BgA" name="Caecum_pls_PortalVein_pls" description="Neighborhood between Cecum/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="qk0qF8uZI06cnoMMMXTreA" secondNeighbor="-zX9e5Gif0qLF9-buV_xlA">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="ntxMBYC4O0Kc6IItXeaJzw" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="_KAKxArpkECEopA4kf0ZeA" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="UGjyRn4Vukm2-3mk_CtRyg" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Transport id="yJwSdwUzNkSwP_izYJ1r4w" name="MassTransferMucosaToPvePlasma" description="Mass transfer from Mucosa:Plasma To Portal Vein: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="3BqgU5LYzEqFODdhU-mU0A" sourceAmount="Lpte9WeV50K2AalO8MrxAw" targetAmount="hqBDuJ9j9Eqjy73I0KZSUA" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="ktrwKPy9NEKE7UHKUReQkg" name="Lumen_coltrans_ColonTransversum_pls" description="Neighborhood between Lumen/Colon Transversum and Mucosa/Colon Transversum/Plasma" mode="Logical" containerType="Other" firstNeighbor="uB1rpzG6qkapR36UK4VYNQ" secondNeighbor="-P41WVvf4kGpY92ttsK8NQ">
-              <Tags>
-                <Tag value="Neighborhood: ColonTransversum / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="7a6sGh3CcUiXuWDpXp5ttg" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="rIozywtIOUG59SsbXsg9Jw" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="Pmu4zootBkKraEHhPAk7mA" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="WOqydZJ2KUOuzkE69HwnuA" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="8a3Te4qf-kWIge_L2xb8Zg" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="7RO3IKTjDkifnUnf6W20dg" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="4yZj3e-4bUa5flzew_2bbQ" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="ujPGcNIK0EOtf-V-bBTbVw" name="ColonAscendens_bc_PortalVein_bc" description="Neighborhood between Colon Ascendens/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="-BbZRBaQ_EGB3LiH3qZ_Ag" secondNeighbor="V3IajphOTUWt3a2j9_LOZA">
-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="WjGvNFioPkygrWq9ATVO4Q" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="HeLgUWorYkG19opWHFSYhQ" name="Mass transfer rate (mucosa to portal vein blood cells)" description="Mass transfer rate (mucosa to portal vein blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="3i-s2cQOQUiZIsQurtJGzg" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Transport id="baw01okR7UmNfC_jfeit3g" name="MassTransferMucosaToPveBC" description="Mass transfer from Mucosa:Blood Cells To Portal Vein: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="5kF4Qyl4Y0OhrFPtaAJPEw" sourceAmount="Ls0R4hvRKki76eHKnnDq6g" targetAmount="3A4PxVITtUOpr85RBMQZlg" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="30ke7hjank6shl8i9ff60g" name="ColonAscendens_pls_PortalVein_pls" description="Neighborhood between Colon Ascendens/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="Aivr7qttHUatCWB0Vus_ew" secondNeighbor="-zX9e5Gif0qLF9-buV_xlA">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="Rnss7hsZFUWLQY9ymwwLBg" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="tzw5DvMPYEqOoTSxEWRo6w" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="XyK-KoNd00ertUqLE2L_1g" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Transport id="JFeCzlkS3kiI1XdgwXQCrg" name="MassTransferMucosaToPvePlasma" description="Mass transfer from Mucosa:Plasma To Portal Vein: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="RxSwTzu8d0iml2iyqroR0g" sourceAmount="0zNjwXhGpkSaSYQZC4yzdw" targetAmount="hqBDuJ9j9Eqjy73I0KZSUA" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="A2dbFb8_P0S-DQUTIB6Evg" name="ColonSigmoid_pls_PortalVein_pls" description="Neighborhood between Colon Sigmoid/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="bzYLFyk2JkmtP6F5xOz6QQ" secondNeighbor="-zX9e5Gif0qLF9-buV_xlA">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="od0ecc4Z3kCkhryHHogvPg" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="WSu1uF6RLkuiAjgGu7a0SA" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="D4zn5z4QN0GXVYulMgYFSQ" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Transport id="QDYIYu8mXECNsawolb9lFA" name="MassTransferMucosaToPvePlasma" description="Mass transfer from Mucosa:Plasma To Portal Vein: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="SUC1LGiVKEe240XtHOZ1Tw" sourceAmount="xTGJR_rEKE6vG1pK_dnKhA" targetAmount="hqBDuJ9j9Eqjy73I0KZSUA" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="DOOesdl3-EKTF-x5Bubifw" name="Lumen_colsigm_ColonSigmoid_cell" description="Neighborhood between Lumen/Colon Sigmoid and Mucosa/Colon Sigmoid/Intracellular" mode="Logical" containerType="Other" firstNeighbor="FF0ppGi5GkaCMtFrfbD1kA" secondNeighbor="dEAYEXl0dk2Rv-tt0gU9NA">
-              <Tags>
-                <Tag value="Neighborhood: ColonSigmoid / Intracellular" />
-              </Tags>
-              <Children>
-                <Container id="jUSayz17YUO4LxqYlivw9A" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="ITgqeMGFhEOZNxoLmfD3bw" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="L7Hijph3_EuoO-2XIbV6JQ" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="k_X4lIIeVUWt0HsT8KAEdw" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="0IIh6FJV0UKyrimES0f1xg" visible="0" canBeVaried="0" />
-                    <Parameter id="Dh6PZEw6zkeroh8-ZW8V5A" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="bOPO_JT8sEOF6PITZSGGVg" visible="0" canBeVaried="0" />
-                    <Parameter id="1Eapr4tRi0CjyaXCcyziuA" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="aZYSS2yfyEqUEbGBDu38yg" visible="0" canBeVaried="0" />
-                    <Parameter id="fLIpyDolO0acFqn7WPhdTA" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="-y8fbQtk8kiw0FGu1Gi7vQ" visible="0" canBeVaried="0" />
-                    <Parameter id="7d0sNBFJeEW5ECt0PcXxrw" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="c8CVAQA3aUiOambC3EzcgQ" visible="0" canBeVaried="1" />
-                    <Parameter id="8ncnF2-QJUyEhs32rs1PBA" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="wjbx6vxr-U-ys78r3dQrnA" visible="0" canBeVaried="0" />
-                    <Parameter id="ItH2deydakiD1_a_vVsL8g" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="2XKmZQVXDkG6Bl4nf-ZqiQ" visible="0" canBeVaried="0" />
-                    <Parameter id="WnrV03VHYUmaxkRHnsSoJA" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="KQgllSQtqk2EfhX37WilDQ" visible="0" canBeVaried="0" />
-                    <Parameter id="oez0ZLha_UKgnKJ5_Vy4kw" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="NJ38btrOWEa1Cg9esiHTGw" visible="0" canBeVaried="0" />
-                    <Parameter id="NSpEINPFeU68zTTIKn8T1Q" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="aWekJ2NVAECIIbxJKJ8L5g" visible="0" canBeVaried="0" />
-                    <Parameter id="8F-X-8eZ7U6nNotGAfoy4Q" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="PEhoVdLppU-G3xULjX_71g" visible="0" canBeVaried="0" />
-                    <Parameter id="K2CC8oDuWEKnuR362-Kwlg" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="7NEiCDSKM0i6GhEpoWb-Mw" visible="0" canBeVaried="0" />
-                    <Parameter id="QWuvgutxDkafPbMDTug17g" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="3xvkxp6qK06bn4DgEtYULA" visible="0" canBeVaried="0" />
-                    <Parameter id="0tlInJ4AdEexV1_7Igx-MQ" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="ezAHDPnckEKYf8L1jOtGfw" visible="0" canBeVaried="0" />
-                    <Parameter id="nuHcH8tTpk-pkf6ewKrmww" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="2IVWcgM31UCSVl8zMDnDhw" visible="0" canBeVaried="0" />
-                    <Parameter id="cw8XBrQKz0yMZsQA495ocw" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DNGx_vFWp0KdOb7CGcoTLQ" visible="0" canBeVaried="0" />
-                    <Parameter id="Oh-2yhhbV0O7hU8HIiseBA" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="LcUCvhU3W0udtbpS1KVhEQ" visible="0" canBeVaried="0" />
-                    <Parameter id="t1B_uoIa6kG7LChZ639kgg" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="YEbmKmAvpECG0bdWMocg9Q" visible="0" canBeVaried="0" />
-                    <Parameter id="xlPC5D82xUS3ybe0_ZUVkw" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="sNNMlbVUOUut2aLPW7bupg" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="TWxn4NuXIkitN7kT-M4SXg" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="5xT4jt0-Q0ezqb7fPF0oEw" visible="0" canBeVaried="0" />
-                    <Parameter id="Iizbz-nBiUqEvGNPDVjz1Q" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="hhUrCV9ee0KZfGG1eddvuA" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="5M8OVfgD5U2bsUOaeHP6ug" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="pGvG5UNdC0Sot3_d3Qdvag" visible="0" canBeVaried="0" />
-                    <Parameter id="V04SoDYbOk-Pl2Ks9R3MgA" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="jJfeJ2YxEki9TK9XP6uUMA" visible="0" canBeVaried="0" />
-                    <Parameter id="J5pafob0Ek6JD2uPHYG6fQ" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DNF0kWPUFk-rtSd0Ng1Mkw" visible="0" canBeVaried="0" />
-                    <Parameter id="be-tM87dhEGqRdwcyD6vZA" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="gxoZyuApjEuzsuLtZuZWmQ" visible="0" canBeVaried="0" />
-                    <Parameter id="5jfoDlozMEWL_jlVFo3Qtg" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="qr_x2cq_Y0C6Ur-VSCP4AQ" visible="0" canBeVaried="0" />
-                    <Parameter id="ykqt6rqEikmGOL1u_UdjFA" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Iph7YhQ5KUmsZWUX2Xf2Wg" visible="0" canBeVaried="0" />
-                    <Parameter id="aqPpDjIsv0Kc-_SstHYWfQ" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="FTB7kyIBw0-iNjzKVHo_Pg" visible="0" canBeVaried="0" />
-                    <Transport id="d2Y-X8LQHki0LEf2LlEVBw" name="DrugAbsorption_trans" description="Drug absorption transcellular" mode="Logical" containerType="Transport" dimension="Amount per time" formula="8amTWAImMkWDIcGgrSe_nQ" sourceAmount="jIGCgtwn-U2Oqcv2W4G-ZQ" targetAmount="_FYwdcJVXUmHAbB3mDuZPw">
-                      <Children>
-                        <Parameter id="ed8iIdclhkCrTV5IEiic4g" name="ProcessRate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="zFMA40W4K0CA7ccSyiIjEA" visible="0" canBeVaried="1" displayUnit="µmol/min">
-                          <Tags>
-                            <Tag value="DrugAbsorption_trans" />
-                            <Tag value="ProcessRate" />
-                            <Tag value="C1" />
-                            <Tag value="Lumen_colsigm_ColonSigmoid_cell" />
-                            <Tag value="Passive" />
-                          </Tags>
-                        </Parameter>
-                      </Children>
-                    </Transport>
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="VPz-hixmg0KKKTMoadfZRg" name="Lumen_colsigm_ColonSigmoid_pls" description="Neighborhood between Lumen/Colon Sigmoid and Mucosa/Colon Sigmoid/Plasma" mode="Logical" containerType="Other" firstNeighbor="FF0ppGi5GkaCMtFrfbD1kA" secondNeighbor="bzYLFyk2JkmtP6F5xOz6QQ">
-              <Tags>
-                <Tag value="Neighborhood: ColonSigmoid / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="hyTeYLoZekO41FzXKaFodg" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="zJSWdAQ4cEWiC0phJcS11w" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="TKP9EtLErEKyBg6FVL-9DQ" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="RNkJUhRFLkSoBm-E_a9fcg" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="Afyrej7_k06GWPcPWU3r_A" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="5T6sVdSCVk-19RcUQzwf-A" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="58sp_GZp6kKht6J860cu_A" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="6AbSNVrP_0mlRz2gqWxngg" name="ColonDescendens_bc_PortalVein_bc" description="Neighborhood between Colon Descendens/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="0Ysv4senlEeNmmozTIAQkw" secondNeighbor="V3IajphOTUWt3a2j9_LOZA">
-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="dE4_a1tFhUqmpdxQF7dQ0g" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="E5hWvWWbdkKpYq6UWArCmA" name="Mass transfer rate (mucosa to portal vein blood cells)" description="Mass transfer rate (mucosa to portal vein blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="gzRFkkg6IECjxrD2ZEB09Q" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Transport id="SBiE4AErYk-RkS8iCaxelw" name="MassTransferMucosaToPveBC" description="Mass transfer from Mucosa:Blood Cells To Portal Vein: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="Z6OsX6geUEy6xwZTAY3HuA" sourceAmount="3eMVtSbfykKuZmsiS31jUg" targetAmount="3A4PxVITtUOpr85RBMQZlg" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="81cB7UH72E6MV9TiAQgaUw" name="ColonDescendens_pls_PortalVein_pls" description="Neighborhood between Colon Descendens/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="IYSOBD2MW0SByEccir1gtg" secondNeighbor="-zX9e5Gif0qLF9-buV_xlA">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="dTmxFckF80iXoeRKh9uDxQ" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="Co_Mbc7i_Eqepc7aVBT_Tg" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="GYKpdJFJsUmDzbfRpx7kug" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Transport id="prM3dT5SJUO416GYUbqdXQ" name="MassTransferMucosaToPvePlasma" description="Mass transfer from Mucosa:Plasma To Portal Vein: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="-GuPIeYx80ep4tW9YNHDBQ" sourceAmount="fRScY5akTkSbcR1hbKcs5Q" targetAmount="hqBDuJ9j9Eqjy73I0KZSUA" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="kK45Q70lJ0SGignU_8Tpuw" name="ColonSigmoid_bc_PortalVein_bc" description="Neighborhood between Colon Sigmoid/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="96RIWxzJSUmdHw6J1qxOyw" secondNeighbor="V3IajphOTUWt3a2j9_LOZA">
-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="DX_i60fyl0WZnVnqwNqBNA" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="YrsPqX5NQUua8AiEDiUW2w" name="Mass transfer rate (mucosa to portal vein blood cells)" description="Mass transfer rate (mucosa to portal vein blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="n33NJTvHaU2hKNgd9ESOkQ" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Transport id="EsZmuwafWk6WNcOjpquzcA" name="MassTransferMucosaToPveBC" description="Mass transfer from Mucosa:Blood Cells To Portal Vein: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="0XwXTyNPP0a_bRApkQOKRw" sourceAmount="nPc7HZ7onEeWVXA5yaAQVg" targetAmount="3A4PxVITtUOpr85RBMQZlg" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="QM8tFgEPskCDyrdj4p8-hw" name="Lumen_coldesc_ColonDescendens_cell" description="Neighborhood between Lumen/Colon Descendens and Mucosa/Colon Descendens/Intracellular" mode="Logical" containerType="Other" firstNeighbor="Tizt5eh3cUGAxWKaiYKVQw" secondNeighbor="yvx9mFVur0KdwvcmwHHcQw">
-              <Tags>
-                <Tag value="Neighborhood: ColonDescendens / Intracellular" />
-              </Tags>
-              <Children>
-                <Container id="2gW5NAWqREORnp6y1W3Ipg" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="UWlX8ficg0CJUVz6xHZgDQ" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="ezAHDPnckEKYf8L1jOtGfw" visible="0" canBeVaried="0" />
-                    <Parameter id="Dc945-cTbkS5rPW1jg-4dg" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DNF0kWPUFk-rtSd0Ng1Mkw" visible="0" canBeVaried="0" />
-                    <Parameter id="UDvaUaRcjk-9fDjYcMegOg" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DNGx_vFWp0KdOb7CGcoTLQ" visible="0" canBeVaried="0" />
-                    <Parameter id="PYjeH1lrX0KoLWQ2H5kcEQ" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="LcUCvhU3W0udtbpS1KVhEQ" visible="0" canBeVaried="0" />
-                    <Parameter id="Ys1bctFDQ0qFXLGGMJgaPw" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="R53cI3ctE0CW-zrWB0Y5Tg" visible="0" canBeVaried="0" />
-                    <Parameter id="XUM164GyqEaq-zCRf6i_tg" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="LfXuaYWZ1UahBGb1fJxBSQ" visible="0" canBeVaried="0" />
-                    <Parameter id="UyUw_8PMrUyXgAqAAIVyZg" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="9bUgfPj8WEaMrHjnYPcaBg" visible="0" canBeVaried="0" />
-                    <Parameter id="OHJmal0GCECgNVSh0Nps1Q" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="PEhoVdLppU-G3xULjX_71g" visible="0" canBeVaried="0" />
-                    <Parameter id="ETmhnWL7xUS_hIy6isQKXw" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="jJfeJ2YxEki9TK9XP6uUMA" visible="0" canBeVaried="0" />
-                    <Parameter id="CX0p8xxRCUiRtgPi36XOYA" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="gxoZyuApjEuzsuLtZuZWmQ" visible="0" canBeVaried="0" />
-                    <Parameter id="4tzxIRsq00ykFSYwoNeXEw" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="qr_x2cq_Y0C6Ur-VSCP4AQ" visible="0" canBeVaried="0" />
-                    <Parameter id="9cma6pqOtEiQtAlwBaUZUg" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Iph7YhQ5KUmsZWUX2Xf2Wg" visible="0" canBeVaried="0" />
-                    <Parameter id="28x_n-A8GUC_QICTHa1cHw" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="aWekJ2NVAECIIbxJKJ8L5g" visible="0" canBeVaried="0" />
-                    <Parameter id="VEklUi_GD0m5Bh_n6Z_ltw" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="_W2-NYk84UWh3cKr31DTQw" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="h3UhljjVAUOhTP0083WkPw" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="COQouIn95UKYSvICdnNQmA" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="PkX15zhNGEigzNofbVYgWg" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="pGvG5UNdC0Sot3_d3Qdvag" visible="0" canBeVaried="0" />
-                    <Parameter id="2mYWlp1bKUi3V6ye8_D1yQ" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="3xvkxp6qK06bn4DgEtYULA" visible="0" canBeVaried="0" />
-                    <Parameter id="i8ejol6tn06h3IDu10KO3A" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="2IVWcgM31UCSVl8zMDnDhw" visible="0" canBeVaried="0" />
-                    <Parameter id="uvw_xlE-CUGk_DqjzOPbjw" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="TConzFPRRE-3YlGeZ4Sudg" visible="0" canBeVaried="0" />
-                    <Parameter id="ombFMbZl0EerOBbBbRAyYw" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="LAOanapz002r38qtCs8g3g" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="9EYMvVQ41kyGYtJsWwYoZA" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="aZYSS2yfyEqUEbGBDu38yg" visible="0" canBeVaried="0" />
-                    <Parameter id="OqwDgCMRdkKFWb9oWbQA3w" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="icGT77WyRUuSy8KyZ57XtQ" visible="0" canBeVaried="1" />
-                    <Parameter id="ocoJLfvvNE2RmbiOB6rJnw" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="xl4warxR5k26wJSA_PhxAA" visible="0" canBeVaried="0" />
-                    <Parameter id="PqY8nXKtf064yek1Gxw6ug" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="cZeWSD5UJU-0eLNPLhWvpA" visible="0" canBeVaried="0" />
-                    <Parameter id="CejUz20G60GKtJP1zo8DAg" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="wD7dDxtIVUiJCaDGH_rGzQ" visible="0" canBeVaried="0" />
-                    <Parameter id="_f_mikUYl0Gm2PlDYGeDSA" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="0IIh6FJV0UKyrimES0f1xg" visible="0" canBeVaried="0" />
-                    <Parameter id="roE8Nos260SrwwTYF1nkCQ" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="KQgllSQtqk2EfhX37WilDQ" visible="0" canBeVaried="0" />
-                    <Parameter id="a4W3L_2c2UCH-TbTu0bN1w" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="7NEiCDSKM0i6GhEpoWb-Mw" visible="0" canBeVaried="0" />
-                    <Parameter id="DoqjmScJe0yFu4Qt5jBxlA" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="bOPO_JT8sEOF6PITZSGGVg" visible="0" canBeVaried="0" />
-                    <Transport id="xZWk9gkva02WU5MZh6MNLw" name="DrugAbsorption_trans" description="Drug absorption transcellular" mode="Logical" containerType="Transport" dimension="Amount per time" formula="BD1dAJKp_UCxfvnyI8QAIg" sourceAmount="yiZ323gtz0WRt_37u8tDPQ" targetAmount="XdsPQQqfnU68je9V8z203Q">
-                      <Children>
-                        <Parameter id="jqzXV6HY1UWSJaXn7rBuBA" name="ProcessRate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="7IpAKD39TUy2KNbEjwcTyg" visible="0" canBeVaried="1" displayUnit="µmol/min">
-                          <Tags>
-                            <Tag value="DrugAbsorption_trans" />
-                            <Tag value="ProcessRate" />
-                            <Tag value="C1" />
-                            <Tag value="Lumen_coldesc_ColonDescendens_cell" />
-                            <Tag value="Passive" />
-                          </Tags>
-                        </Parameter>
-                      </Children>
-                    </Transport>
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="8f97m3NM4kqXWb7RwSBOUg" name="Lumen_coldesc_ColonDescendens_pls" description="Neighborhood between Lumen/Colon Descendens and Mucosa/Colon Descendens/Plasma" mode="Logical" containerType="Other" firstNeighbor="Tizt5eh3cUGAxWKaiYKVQw" secondNeighbor="IYSOBD2MW0SByEccir1gtg">
-              <Tags>
-                <Tag value="Neighborhood: ColonDescendens / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="Oabi5Uv4yEywb6jtcDISYQ" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="nkDbXr-XWUmgv7uysc8PpA" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="4iUYvXDlqEacAxGkAqC67w" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="GMfNmCGdQkuBWKgOP-4XCg" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="YID9qeSfWkydTVAW3WuaOg" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="maJTZfliq0adluLC0dd-FQ" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="2auV62OhwEKmuzNhp-oxqQ" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="bFmCYpyht06YSWiPbjEltA" name="ColonTransversum_bc_PortalVein_bc" description="Neighborhood between Colon Transversum/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="nK4V9tiRUUy-zjLhRo56OA" secondNeighbor="V3IajphOTUWt3a2j9_LOZA">
-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="nTMJsEsum02hjud8Vcgq-A" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="WOu2eLBpSEOyCqyJb8fk0A" name="Mass transfer rate (mucosa to portal vein blood cells)" description="Mass transfer rate (mucosa to portal vein blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="4RexIDSOV0OT0CIEJ-8DyA" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Transport id="ZzNJsUEjFEipB-9QU484ZQ" name="MassTransferMucosaToPveBC" description="Mass transfer from Mucosa:Blood Cells To Portal Vein: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="BizocUffukWBg7MqtXcfPw" sourceAmount="2BQp7lKGjkCgjUSXvOs6QQ" targetAmount="3A4PxVITtUOpr85RBMQZlg" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="4SnuuCYaFUqjVDubpE6arw" name="ColonTransversum_pls_PortalVein_pls" description="Neighborhood between Colon Transversum/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="-P41WVvf4kGpY92ttsK8NQ" secondNeighbor="-zX9e5Gif0qLF9-buV_xlA">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="7eh8xvm7IUiDXWeNh_92tQ" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="GmiZaAuWkUa1DAcZhMnTiA" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="QY_8WMM6H0SRblh5p3m8FQ" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Transport id="_ty3O4XMsUG9f0s3JrLT7w" name="MassTransferMucosaToPvePlasma" description="Mass transfer from Mucosa:Plasma To Portal Vein: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="HWTCMuZGXUenFIHk2eMV7A" sourceAmount="bnMs2biCD0u9uVZoaq3RZQ" targetAmount="hqBDuJ9j9Eqjy73I0KZSUA" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="PAtG_V9NNkCotrE3nlnmAA" name="Lumen_coltrans_ColonTransversum_cell" description="Neighborhood between Lumen/Colon Transversum and Mucosa/Colon Transversum/Intracellular" mode="Logical" containerType="Other" firstNeighbor="uB1rpzG6qkapR36UK4VYNQ" secondNeighbor="bQfRvdb_CEakRfpxkmjp1g">
-              <Tags>
-                <Tag value="Neighborhood: ColonTransversum / Intracellular" />
-              </Tags>
-              <Children>
-                <Container id="Uk8DJkB-AUix4Jc96wvFrQ" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="We2t05Mhv0em3SbW_JnRuQ" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="jb4Z8A0Z1kif3SUqv2N2pw" visible="0" canBeVaried="0" />
-                    <Parameter id="6_SrTUJ6aUmZO2EGO-tThg" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="4Zml2j67nEmYONQia7MxTQ" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="_uYfmx9v3UKKAMkHhNtAOA" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="bOPO_JT8sEOF6PITZSGGVg" visible="0" canBeVaried="0" />
-                    <Parameter id="x9QEyvCw_k-6tmf5660L0Q" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="aZYSS2yfyEqUEbGBDu38yg" visible="0" canBeVaried="0" />
-                    <Parameter id="Pcfa__MchUetzQoIj1mpiw" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="eq49nAmg3kSap3xstrHVQw" visible="0" canBeVaried="0" />
-                    <Parameter id="cZ4mXdNJaUGagLd6NlmVGA" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DNGx_vFWp0KdOb7CGcoTLQ" visible="0" canBeVaried="0" />
-                    <Parameter id="HwNIv4sofkmJgLDhpBM2nQ" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="2rz940Tfm0mkCHYo05Rz3Q" visible="0" canBeVaried="0" />
-                    <Parameter id="JMJi-xXLrUiNHAAetAaWPA" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="XauSM7UQukeTY7249KcMmw" visible="0" canBeVaried="0" />
-                    <Parameter id="NWLYY7jEV0Kx_TygLCsw3Q" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="0IIh6FJV0UKyrimES0f1xg" visible="0" canBeVaried="0" />
-                    <Parameter id="4NgddAgeeUyjYhvMf8JrIA" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="KQgllSQtqk2EfhX37WilDQ" visible="0" canBeVaried="0" />
-                    <Parameter id="LnKqJBWS6k6gqyz3Iq8wZw" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="7NEiCDSKM0i6GhEpoWb-Mw" visible="0" canBeVaried="0" />
-                    <Parameter id="pYVwcrK_50WC5Atsv1NvaA" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="3xvkxp6qK06bn4DgEtYULA" visible="0" canBeVaried="0" />
-                    <Parameter id="BB5ywbOzqkems6502-NHeg" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="ezAHDPnckEKYf8L1jOtGfw" visible="0" canBeVaried="0" />
-                    <Parameter id="jeZwgx5TxUSAKd0QJGkIKQ" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="j2UikfOtLkeEX74qoHnjaQ" visible="0" canBeVaried="1" />
-                    <Parameter id="WOnTozo7A0m5MDHh6pdwHw" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="LcUCvhU3W0udtbpS1KVhEQ" visible="0" canBeVaried="0" />
-                    <Parameter id="nY4uJPRu8UqtIBp6fi6OtQ" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="2IVWcgM31UCSVl8zMDnDhw" visible="0" canBeVaried="0" />
-                    <Parameter id="KuvPKZuqhkaTKpG23vjIQw" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Iph7YhQ5KUmsZWUX2Xf2Wg" visible="0" canBeVaried="0" />
-                    <Parameter id="08QPDzdpKkm8gJzmmsGERw" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="ud6Lho1In0CC7LTjESlRBg" visible="0" canBeVaried="0" />
-                    <Parameter id="-j8WKX9Wmku6YWbu_nqc2A" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="uhfSXqrQvUaPieYEr-qFtg" visible="0" canBeVaried="0" />
-                    <Parameter id="0sOD5CisMkKI1oO54OC90A" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="x3x4kOtnrECym84BGneZ3g" visible="0" canBeVaried="0" />
-                    <Parameter id="9oe2NFxA-E2esQPwmP82gg" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="PEhoVdLppU-G3xULjX_71g" visible="0" canBeVaried="0" />
-                    <Parameter id="TmXKX7OanUyluU24KeLlmQ" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="pGvG5UNdC0Sot3_d3Qdvag" visible="0" canBeVaried="0" />
-                    <Parameter id="8XB72tzLTEuwUemtf-XbJA" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="jJfeJ2YxEki9TK9XP6uUMA" visible="0" canBeVaried="0" />
-                    <Parameter id="IvkTPV1AN0e3kibG9jEGcw" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DNF0kWPUFk-rtSd0Ng1Mkw" visible="0" canBeVaried="0" />
-                    <Parameter id="8XL5KZztHkuilqGP1PtJcg" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="qr_x2cq_Y0C6Ur-VSCP4AQ" visible="0" canBeVaried="0" />
-                    <Parameter id="45f2TCm4rUWLJ80A2YWdOA" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="aWekJ2NVAECIIbxJKJ8L5g" visible="0" canBeVaried="0" />
-                    <Parameter id="_A5snORjlUCvg23xM3uTjA" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="-5tSttqPf02ASx8lRUcZqg" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="o7Z1S00JhUGM7EqBoqUcfQ" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="3Hd5PrbDhEiGMU-6VIhkXA" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="Znsp_iZTxEWlDBfZpc0E-A" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="gxoZyuApjEuzsuLtZuZWmQ" visible="0" canBeVaried="0" />
-                    <Transport id="vKdrzgdDf0CfyWzRQSbaTA" name="DrugAbsorption_trans" description="Drug absorption transcellular" mode="Logical" containerType="Transport" dimension="Amount per time" formula="NGMIraI3JUOZIGd3dKfoPw" sourceAmount="B3i4ajvEPkWwF-QJhPT-RA" targetAmount="H0qyxGwyUkWmeHAlvjEj4w">
-                      <Children>
-                        <Parameter id="ayIGRBDmXEOiu_ccvWrqMQ" name="ProcessRate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="g9tFz37ZDkeADbvOroeIzA" visible="0" canBeVaried="1" displayUnit="µmol/min">
-                          <Tags>
-                            <Tag value="DrugAbsorption_trans" />
-                            <Tag value="ProcessRate" />
-                            <Tag value="C1" />
-                            <Tag value="Lumen_coltrans_ColonTransversum_cell" />
-                            <Tag value="Passive" />
-                          </Tags>
-                        </Parameter>
-                      </Children>
-                    </Transport>
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="LjWB6rytgUeDEqVpGfm4Ag" name="Lumen_colasc_ColonAscendens_cell" description="Neighborhood between Lumen/Colon Ascendens and Mucosa/Colon Ascendens/Intracellular" mode="Logical" containerType="Other" firstNeighbor="jhPiKsemqE2D9wuuFrqxsw" secondNeighbor="Qny8z-gEIUO-cU6ir0RqzA">
-              <Tags>
-                <Tag value="Neighborhood: ColonAscendens / Intracellular" />
-              </Tags>
-              <Children>
-                <Container id="5LZuKZzq3Ea-HLdPpwIijg" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="Sv7u99rmZkuJC_P1G4_FmQ" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="rdiuY1t87kuwKt5MEpldDQ" visible="0" canBeVaried="0" />
-                    <Parameter id="YSwuysr0A0a_n2LdCgRLlA" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="HrDbqzU3BkmyZxzHkLbLJA" visible="0" canBeVaried="0" />
-                    <Parameter id="Bb1toNe9D0O6VSxPBjYUzQ" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="CMygyw7Ycka3VMl5OVtYVA" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="e3Xyxb3kF06ZEEtlvTZ-OQ" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="bOPO_JT8sEOF6PITZSGGVg" visible="0" canBeVaried="0" />
-                    <Parameter id="KWSLw_-rS02cEYntlZd4ww" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="aZYSS2yfyEqUEbGBDu38yg" visible="0" canBeVaried="0" />
-                    <Parameter id="b4yF3Cyon0mHG6sjs1eWvQ" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="1aK-WkQilEaQvWIqoRanaA" visible="0" canBeVaried="1" />
-                    <Parameter id="mT1nj0ZvS061thSiSawvJA" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="JX-VumX3fkSs2rGi3gM1MQ" visible="0" canBeVaried="0" />
-                    <Parameter id="vsni4_rZRkWXgxliiDBuYQ" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="WNRN_yyuhEqEacw7RfnGAw" visible="0" canBeVaried="0" />
-                    <Parameter id="W8ZPEvzn702hCQiRO0syeA" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="0IIh6FJV0UKyrimES0f1xg" visible="0" canBeVaried="0" />
-                    <Parameter id="DSsbgEqPA0CO8tF0ZuNPtw" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="KQgllSQtqk2EfhX37WilDQ" visible="0" canBeVaried="0" />
-                    <Parameter id="PqKKe3FIXEOFA6UGcmwBZg" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="7NEiCDSKM0i6GhEpoWb-Mw" visible="0" canBeVaried="0" />
-                    <Parameter id="_ssAkN9njESxeVd8G-c5ew" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="3xvkxp6qK06bn4DgEtYULA" visible="0" canBeVaried="0" />
-                    <Parameter id="5o0ITePF-Umpz7z6Wk2ETw" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="ezAHDPnckEKYf8L1jOtGfw" visible="0" canBeVaried="0" />
-                    <Parameter id="gKS2vC82zUOI_7z7Rlhifg" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="2IVWcgM31UCSVl8zMDnDhw" visible="0" canBeVaried="0" />
-                    <Parameter id="2dYNeTHmQUyIDnquF8XPaA" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DNGx_vFWp0KdOb7CGcoTLQ" visible="0" canBeVaried="0" />
-                    <Parameter id="WLa2NgMHcEybXTdrlbxveg" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="LcUCvhU3W0udtbpS1KVhEQ" visible="0" canBeVaried="0" />
-                    <Parameter id="w3-jtY2OfkyGl6IJ0ssyIg" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="-NEfNAk5BkeqsSm89zu2ig" visible="0" canBeVaried="0" />
-                    <Parameter id="-lWnnE1lXEuQTjXkLWTEow" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="WDU5b6PS4UuzuG7tIVBEdA" visible="0" canBeVaried="0" />
-                    <Parameter id="pnWMC5ZgvkSHtJqV3AdByA" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="bcFrf7s2kEOkv3-JRiwp1Q" visible="0" canBeVaried="0" />
-                    <Parameter id="b0QsMS1FdUWg4fUdb5Oxfw" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="rYpN5XvH2ECr2TrP9oYtiA" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="eTZr6ThftU6t0tM7kdOWag" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="PEhoVdLppU-G3xULjX_71g" visible="0" canBeVaried="0" />
-                    <Parameter id="8EZnMTOkoUSp_lm_iskBdQ" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="pGvG5UNdC0Sot3_d3Qdvag" visible="0" canBeVaried="0" />
-                    <Parameter id="SkQ9yaHvUECW3427Si3Caw" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="jJfeJ2YxEki9TK9XP6uUMA" visible="0" canBeVaried="0" />
-                    <Parameter id="-BEAIQtafkOmLHyMMGvpuQ" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DNF0kWPUFk-rtSd0Ng1Mkw" visible="0" canBeVaried="0" />
-                    <Parameter id="Jnu2EX1VRky2Lpd45qvZ_g" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="gxoZyuApjEuzsuLtZuZWmQ" visible="0" canBeVaried="0" />
-                    <Parameter id="U3ukwT5VDUurv2H03J6GZw" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="qr_x2cq_Y0C6Ur-VSCP4AQ" visible="0" canBeVaried="0" />
-                    <Parameter id="KSjBJz5zI0y0e0JIGyibwg" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Iph7YhQ5KUmsZWUX2Xf2Wg" visible="0" canBeVaried="0" />
-                    <Parameter id="CNzIdPPmpUaPGXukx6HKZw" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="R-AykvxorU6Kzdi4HnNHGg" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="J0H4HMwZSk2viXqsFKDZIA" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="aWekJ2NVAECIIbxJKJ8L5g" visible="0" canBeVaried="0" />
-                    <Transport id="4cNsPhHczkGhQyfpbJQApg" name="DrugAbsorption_trans" description="Drug absorption transcellular" mode="Logical" containerType="Transport" dimension="Amount per time" formula="nTmJfOVbg0S4bDtKDqXXvg" sourceAmount="mgzsCzTwXkGLoEv-ZBAnNQ" targetAmount="Y5D_k9113E2RRgqowuESsw">
-                      <Children>
-                        <Parameter id="aR8YmrhGDkmc_hC--zBp-Q" name="ProcessRate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="xdG_Re5dC06d-dWW03Wmmw" visible="0" canBeVaried="1" displayUnit="µmol/min">
-                          <Tags>
-                            <Tag value="DrugAbsorption_trans" />
-                            <Tag value="ProcessRate" />
-                            <Tag value="C1" />
-                            <Tag value="Lumen_colasc_ColonAscendens_cell" />
-                            <Tag value="Passive" />
-                          </Tags>
-                        </Parameter>
-                      </Children>
-                    </Transport>
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="59wWKxgQgU2MOUuTSRlv4w" name="Lumen_colasc_ColonAscendens_pls" description="Neighborhood between Lumen/Colon Ascendens and Mucosa/Colon Ascendens/Plasma" mode="Logical" containerType="Other" firstNeighbor="jhPiKsemqE2D9wuuFrqxsw" secondNeighbor="Aivr7qttHUatCWB0Vus_ew">
-              <Tags>
-                <Tag value="Neighborhood: ColonAscendens / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="Wqh87a2EKkeQciYOncNUUg" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="KlYS9lDuK0CRmj2rY3SOzQ" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="uJR983R2Vk-Ffh8uTypLjA" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="BfBRHgjVeESWpMzhUzSstA" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="j9rzTG61Ok-9AT5w4Qqd7g" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="wZEPVWZ9VkOx_nFCd_yhwA" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="gHae4Hcct0a7d2opTKL_PQ" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="0f35OxOGQUu9qFIB6zpQXA" name="ArterialBlood_pls_Kidney_pls" description="Neighborhood between Arterial Blood/Plasma and Kidney/Plasma" mode="Logical" containerType="Other" firstNeighbor="qJqHlxhje0erBO7-fTj4-g" secondNeighbor="eUFCZIU4ekuNusmv0rogQA">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="N6FvW_skw0WC3HwemxhVhA" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="NM4NhUYj70GHnqVa1YYr1Q" name="MassTransferBloodPool2OrgPl" description="Mass transfer from Arterial Blood: Plasma to organ: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="0s7pXX0_BEaTsJz4zIGxUA" sourceAmount="n0un2GZNyUWFQsjdUS5RGA" targetAmount="E1GgL5W3o0mtgLyXCveGWQ" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="181v9PBhDUy0AaSTYsu4Bw" name="ArterialBlood_pls_LargeIntestine_pls" description="Neighborhood between Arterial Blood/Plasma and Large Intestine/Plasma" mode="Logical" containerType="Other" firstNeighbor="qJqHlxhje0erBO7-fTj4-g" secondNeighbor="uvQs1PS9aUqsBpd5BT5HkA">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="L5U8EX8PLk23Vi9x37cvcw" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="MNt9qcLsaU6QvPig4SUuRQ" name="MassTransferBloodPool2OrgPl" description="Mass transfer from Arterial Blood: Plasma to organ: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="9_cpJhct7EiVMyLtUAllUQ" sourceAmount="n0un2GZNyUWFQsjdUS5RGA" targetAmount="xpcrmRU34EqRDnqQj6ZOeA" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="aJdYe0fofEu_jALefw-Vig" name="ArterialBlood_pls_Liver_pls" description="Neighborhood between Arterial Blood/Plasma and Liver/Plasma" mode="Logical" containerType="Other" firstNeighbor="qJqHlxhje0erBO7-fTj4-g" secondNeighbor="5FNaxPygXkWpARUfOC0rDA">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="S3WP9zaTdk6MlGvnhKB7sA" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="oN8lXDE41UGdq-VjH2QH9w" name="MassTransferBloodPool2OrgPl" description="Mass transfer from Arterial Blood: Plasma to organ: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="i8Uzqki2XEenUXXXrAb2rQ" sourceAmount="n0un2GZNyUWFQsjdUS5RGA" targetAmount="T_cXaPk7BEyWVth9NnrBzw" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="eBzh1XStWkaL8FhNMzs4Pw" name="ArterialBlood_pls_Muscle_pls" description="Neighborhood between Arterial Blood/Plasma and Muscle/Plasma" mode="Logical" containerType="Other" firstNeighbor="qJqHlxhje0erBO7-fTj4-g" secondNeighbor="XRLei8Ut4k69NW71TsrsFA">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="qyGqXV9NIUS-D-_9HqujEg" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="finho5VyIECDclrjm-xYfw" name="MassTransferBloodPool2OrgPl" description="Mass transfer from Arterial Blood: Plasma to organ: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="IMSUXNeNB0OPif7VdBpDnw" sourceAmount="n0un2GZNyUWFQsjdUS5RGA" targetAmount="JbH2ysob6kW6Qm7S2hrU2g" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="2nCaXNW33kyc72KosAtLTA" name="ArterialBlood_pls_Pancreas_pls" description="Neighborhood between Arterial Blood/Plasma and Pancreas/Plasma" mode="Logical" containerType="Other" firstNeighbor="qJqHlxhje0erBO7-fTj4-g" secondNeighbor="cctLJe2tcEmrG89fHAxBug">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="-mhBaM43AUSEUIXQeTpBcw" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="yM02xkUJqkC4LBW08OcV5g" name="MassTransferBloodPool2OrgPl" description="Mass transfer from Arterial Blood: Plasma to organ: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="5SGZhd1fT0unBgqoPDyLiw" sourceAmount="n0un2GZNyUWFQsjdUS5RGA" targetAmount="5o8ad95eVkm36IzpkEUdTg" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="IWPVW25nlUOyD-HyXKyvaw" name="ArterialBlood_pls_Skin_pls" description="Neighborhood between Arterial Blood/Plasma and Skin/Plasma" mode="Logical" containerType="Other" firstNeighbor="qJqHlxhje0erBO7-fTj4-g" secondNeighbor="Xg7ardQtf0-u4B4xI_Q48w">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="3W7EqifQPU-1W2FQrQQp0A" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="DBt4A2cPgUyNCr7GFgyQag" name="MassTransferBloodPool2OrgPl" description="Mass transfer from Arterial Blood: Plasma to organ: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="CMoxK21o7k633wBlpUo8eQ" sourceAmount="n0un2GZNyUWFQsjdUS5RGA" targetAmount="FRvVMGhi8UOBMOTbm5lolA" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="ZRH0IyFZhEe8Y6S9NXGIsQ" name="ArterialBlood_pls_SmallIntestine_pls" description="Neighborhood between Arterial Blood/Plasma and Small Intestine/Plasma" mode="Logical" containerType="Other" firstNeighbor="qJqHlxhje0erBO7-fTj4-g" secondNeighbor="v7QydXWpf0-VYKE0_MwWVQ">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="WOWxzo1c10umif8yFvM0WA" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="pVNyuVzePES1l2LeP3Maog" name="MassTransferBloodPool2OrgPl" description="Mass transfer from Arterial Blood: Plasma to organ: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="ceoOi64Aj0uHsljzPu9G0A" sourceAmount="n0un2GZNyUWFQsjdUS5RGA" targetAmount="f8G7zu_9zEK_ZkVtpIfeVw" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="N5va1x04AEaI_ZdDfxX1Hg" name="ArterialBlood_pls_Fat_pls" description="Neighborhood between Arterial Blood/Plasma and Fat/Plasma" mode="Logical" containerType="Other" firstNeighbor="qJqHlxhje0erBO7-fTj4-g" secondNeighbor="l3cprPldy0-s1EHY_moWpQ">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="XTSfpM4rN0eoI_R2whavJA" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="9XJGP9e2oka5pdLjnC3w8g" name="MassTransferBloodPool2OrgPl" description="Mass transfer from Arterial Blood: Plasma to organ: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="EAovPT8yl0S8NeARfMGAQw" sourceAmount="n0un2GZNyUWFQsjdUS5RGA" targetAmount="oe9lGPCNGkOTlj2HvT3xWA" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="Zc0xKze_S0mVfOf_bi2w5A" name="ArterialBlood_pls_Stomach_pls" description="Neighborhood between Arterial Blood/Plasma and Stomach/Plasma" mode="Logical" containerType="Other" firstNeighbor="qJqHlxhje0erBO7-fTj4-g" secondNeighbor="HZ6pfKhao0S84LcP_vvjSQ">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="IsSexBciRkOLlA1tQIQLZA" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="tueEaNLugk61injTB71qGA" name="MassTransferBloodPool2OrgPl" description="Mass transfer from Arterial Blood: Plasma to organ: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="uid635Sajk6FTZcnKXOqQw" sourceAmount="n0un2GZNyUWFQsjdUS5RGA" targetAmount="bgD3avhorEm8i92Um2o6Mw" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="3bqy2rlJjUqjAbQiLPa2rQ" name="ArterialBlood_pls_Spleen_pls" description="Neighborhood between Arterial Blood/Plasma and Spleen/Plasma" mode="Logical" containerType="Other" firstNeighbor="qJqHlxhje0erBO7-fTj4-g" secondNeighbor="se5WEELXjEOw38dYu8tSjg">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="PSy6O7RKTU2dlPk_l2usEA" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="JL32JLwz_0atoCnIhTNglQ" name="MassTransferBloodPool2OrgPl" description="Mass transfer from Arterial Blood: Plasma to organ: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="IlmVUslnq0uWG44WIJTkzg" sourceAmount="n0un2GZNyUWFQsjdUS5RGA" targetAmount="89VKmmFVs0qTmpo4TCEX_A" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="cW6GUFAx3k-9Xdfs9OskMQ" name="ArterialBlood_bc_LargeIntestine_bc" description="Neighborhood between Arterial Blood/Blood Cells and Large Intestine/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="0_QXjFTwnEy8-V1CtkHsew" secondNeighbor="SXH64aI-W0uPsXU5nSDPlA">
-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="yKOo58kwHkO9Qx_IPNmQgw" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="a_Aql0YvtU-Zcp9_trU1EA" name="MassTransferBloodPool2OrgRBC" description="Mass transfer from ArterialBlood: BloodCells to organ: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="I963OEiXRkm76CTbCRQLog" sourceAmount="HVsSKkWIVECLvyey2mYIPw" targetAmount="1CoHmlwfmEyD48lxr-SSNg" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="UH6QM_N53kOu6Wg_EmJvOw" name="ArterialBlood_bc_Bone_bc" description="Neighborhood between Arterial Blood/Blood Cells and Bone/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="0_QXjFTwnEy8-V1CtkHsew" secondNeighbor="JwQ0XK3ejkegaPcI9YkrlQ">
-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="dN-lmDxO2EmX6mnjRPyoDg" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="ZSx73b4YA0qoxPxDjgan8g" name="MassTransferBloodPool2OrgRBC" description="Mass transfer from ArterialBlood: BloodCells to organ: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="63G8cBgQzEyhSnO6LbnISg" sourceAmount="HVsSKkWIVECLvyey2mYIPw" targetAmount="AcinE8HyyU-Q6g1cB8m9ew" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="T1-P_dXrIUy6pIG9MWlwXw" name="ArterialBlood_bc_Brain_bc" description="Neighborhood between Arterial Blood/Blood Cells and Brain/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="0_QXjFTwnEy8-V1CtkHsew" secondNeighbor="8GqTrt1bsEm2HdRl-ptQbA">
-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="CwbXyl1JP0ihaQHrMKPOdQ" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="jwhNCb2ymUKYti--11CIkQ" name="MassTransferBloodPool2OrgRBC" description="Mass transfer from ArterialBlood: BloodCells to organ: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="3BIYakWNl0WU5KDZqx0s8Q" sourceAmount="HVsSKkWIVECLvyey2mYIPw" targetAmount="qMH9c4X4Ek6ugLGK4dEEug" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="k4ePwMMjQ0uhFCcsrO7tVw" name="ArterialBlood_bc_Fat_bc" description="Neighborhood between Arterial Blood/Blood Cells and Fat/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="0_QXjFTwnEy8-V1CtkHsew" secondNeighbor="C6Aak1KuHE6WEnBWIms5EQ">
-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
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-              <Children>
-                <Container id="NAV475SY3UuyCvEEh7RxHQ" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="oAvbXbr1kEm6jglhzwgv-w" name="MassTransferBloodPool2OrgRBC" description="Mass transfer from ArterialBlood: BloodCells to organ: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="3-HfTQdlbk-1IFLVsFKJwA" sourceAmount="HVsSKkWIVECLvyey2mYIPw" targetAmount="8YO8dduw-0WdLQKfJY0mOg" />
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-            </Neighborhood>
-            <Neighborhood id="WV7T7OVF302puc4q9vFW2Q" name="ArterialBlood_bc_Gonads_bc" description="Neighborhood between Arterial Blood/Blood Cells and Gonads/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="0_QXjFTwnEy8-V1CtkHsew" secondNeighbor="4_tlbol5sEOUurLb-QmrqA">
-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="M_iM1XlGtECWHD5tSMHjiQ" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="wSxGxz7HFUGTYvFxGCpRFg" name="MassTransferBloodPool2OrgRBC" description="Mass transfer from ArterialBlood: BloodCells to organ: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="vttKidv8tkmbCaCSmBtwOA" sourceAmount="HVsSKkWIVECLvyey2mYIPw" targetAmount="NMsvr4OvokeBZq8LJ-XvXQ" />
-                  </Children>
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-            </Neighborhood>
-            <Neighborhood id="vbqQ4BkcZk20bZCsBbpzjQ" name="ArterialBlood_pls_Heart_pls" description="Neighborhood between Arterial Blood/Plasma and Heart/Plasma" mode="Logical" containerType="Other" firstNeighbor="qJqHlxhje0erBO7-fTj4-g" secondNeighbor="EEBjpKNEz0iYdJEn57dB_A">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="gLrCoRtaLkGAz9LH6a9c3g" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="hMLqcxsQiEia4zHxphIg0w" name="MassTransferBloodPool2OrgPl" description="Mass transfer from Arterial Blood: Plasma to organ: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="V3XI_-gyjE2Rn9xR3GPNhA" sourceAmount="n0un2GZNyUWFQsjdUS5RGA" targetAmount="qoaU-KhmBkSuINyqySeM2A" />
-                  </Children>
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-            <Neighborhood id="WbUiBwTJKk-ED61VUaw_uw" name="ArterialBlood_bc_Kidney_bc" description="Neighborhood between Arterial Blood/Blood Cells and Kidney/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="0_QXjFTwnEy8-V1CtkHsew" secondNeighbor="fhpOPLdsBEC4DtZUc1zwcA">
-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="7n4s4UCuWk-7jtU50u8D7g" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="2Pp-uV_cxEyY052kop1avg" name="MassTransferBloodPool2OrgRBC" description="Mass transfer from ArterialBlood: BloodCells to organ: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="abvQ3U2p8UCpcU5uvrsgjA" sourceAmount="HVsSKkWIVECLvyey2mYIPw" targetAmount="s0ARpvfc_kCXvSg1uyJo7w" />
-                  </Children>
-                </Container>
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-            <Neighborhood id="LxjeDGEiGUq7iIgVQVuKvg" name="ArterialBlood_bc_Liver_bc" description="Neighborhood between Arterial Blood/Blood Cells and Liver/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="0_QXjFTwnEy8-V1CtkHsew" secondNeighbor="5yZ7vQGKrEq4RZIcazhTBQ">
-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="P57dqTta-0Ky6yAISuUA1Q" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="rccwLSbLZkqWxOZHTZ1Njw" name="MassTransferBloodPool2OrgRBC" description="Mass transfer from ArterialBlood: BloodCells to organ: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="57todndwBES4sJkZ4JKG-w" sourceAmount="HVsSKkWIVECLvyey2mYIPw" targetAmount="d0NG98bkQ0uyp6XKGUEC_Q" />
-                  </Children>
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-            <Neighborhood id="sXnv58n7H0SMSkah6dJmKQ" name="ArterialBlood_bc_Muscle_bc" description="Neighborhood between Arterial Blood/Blood Cells and Muscle/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="0_QXjFTwnEy8-V1CtkHsew" secondNeighbor="_qU5KwpSU0W_lpkw1fcMqg">
-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="MO39Yx2ZqUqQ7vQo9OAW_w" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="shcYi1QewUW5Ilg2e0B6iQ" name="MassTransferBloodPool2OrgRBC" description="Mass transfer from ArterialBlood: BloodCells to organ: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="sIgeKjvtqUyvi3NgmpST5A" sourceAmount="HVsSKkWIVECLvyey2mYIPw" targetAmount="27a1Npm_QEaEQOPqqma4rw" />
-                  </Children>
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-            <Neighborhood id="LrWnC57cE0WXZuSuZFHDUQ" name="ArterialBlood_bc_Pancreas_bc" description="Neighborhood between Arterial Blood/Blood Cells and Pancreas/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="0_QXjFTwnEy8-V1CtkHsew" secondNeighbor="MeBFC58XdEOor4pLtkobow">
-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="V0goqTcDuk-ThqTcKEwyhg" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="yRnAeciWJ02msILJD7BdYA" name="MassTransferBloodPool2OrgRBC" description="Mass transfer from ArterialBlood: BloodCells to organ: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="1s6OCupxOU2E3MzOKMaNtw" sourceAmount="HVsSKkWIVECLvyey2mYIPw" targetAmount="REWBabOvWEqf_0a-yS75TA" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="rw_dhoQgOkqVV_aF3Wr_2Q" name="ArterialBlood_bc_Skin_bc" description="Neighborhood between Arterial Blood/Blood Cells and Skin/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="0_QXjFTwnEy8-V1CtkHsew" secondNeighbor="4S7otm2HZU6QSl2UbAf8-Q">
-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="m-dxWd9orUq-6dHQ8Uf-cQ" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="QfDtOfTSTUCD3vfMOqfpXw" name="MassTransferBloodPool2OrgRBC" description="Mass transfer from ArterialBlood: BloodCells to organ: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="27sM1m-MD0C8vjrqsfxfrg" sourceAmount="HVsSKkWIVECLvyey2mYIPw" targetAmount="DhjTerwdiEag5vbskJtPZw" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="zUZiNtkLk02ttSoP0C1Vjw" name="ArterialBlood_bc_SmallIntestine_bc" description="Neighborhood between Arterial Blood/Blood Cells and Small Intestine/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="0_QXjFTwnEy8-V1CtkHsew" secondNeighbor="BO_2kdQ94EefqAdvRA1T2Q">
-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="bJxHGhRoz02cOtOzOUUK-Q" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="IwZ0u1mRT0q9ykK3XIAHsA" name="MassTransferBloodPool2OrgRBC" description="Mass transfer from ArterialBlood: BloodCells to organ: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="2ZaPbj2vKk6_rOcENJ2Vew" sourceAmount="HVsSKkWIVECLvyey2mYIPw" targetAmount="gACrDjDg5UuEdDtbqzvxDA" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="jXgQQZQiSkqshmTUa378vA" name="ArterialBlood_bc_Spleen_bc" description="Neighborhood between Arterial Blood/Blood Cells and Spleen/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="0_QXjFTwnEy8-V1CtkHsew" secondNeighbor="ynfwPF5DH0CK-Pig1QT3GQ">
-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="QDBw3RGR0U2-HdGUw2tUog" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="7MfyXPMSVkSBDyj35X_kZg" name="MassTransferBloodPool2OrgRBC" description="Mass transfer from ArterialBlood: BloodCells to organ: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="-PNgNEQ90ky5pKSoJywyXw" sourceAmount="HVsSKkWIVECLvyey2mYIPw" targetAmount="gFh2BN_Bg0uEOyNf12mJCg" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="zH8yEXiu_UuhvDS1yMAdrw" name="ArterialBlood_bc_Stomach_bc" description="Neighborhood between Arterial Blood/Blood Cells and Stomach/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="0_QXjFTwnEy8-V1CtkHsew" secondNeighbor="J3KHzmzoG0ybBAX8Q-IY2w">
-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="4rFahWDPQUC661iwEyGl1g" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="mI2PEcGrpUmElM9tlfsWhA" name="MassTransferBloodPool2OrgRBC" description="Mass transfer from ArterialBlood: BloodCells to organ: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="E0NmBhWMK0S1CHpATzXEQA" sourceAmount="HVsSKkWIVECLvyey2mYIPw" targetAmount="PyfLvFgK0EK6vo6Wn0xZ1g" />
-                  </Children>
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-            <Neighborhood id="4MjKYrQyG0-19LwX99MDHQ" name="ArterialBlood_pls_Bone_pls" description="Neighborhood between Arterial Blood/Plasma and Bone/Plasma" mode="Logical" containerType="Other" firstNeighbor="qJqHlxhje0erBO7-fTj4-g" secondNeighbor="Ex79yncWLUC87AX_bbw_4Q">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="3K_H2Rmfska2yGhs8GsdIg" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="L3XBn8lhZE2yQEpnWOdZFQ" name="MassTransferBloodPool2OrgPl" description="Mass transfer from Arterial Blood: Plasma to organ: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="xzsreic-7U6yHswvulOazg" sourceAmount="n0un2GZNyUWFQsjdUS5RGA" targetAmount="Zx-yrj6TNEiFakW3eAjvUw" />
-                  </Children>
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-            <Neighborhood id="TzluKI5h0Eu6Tn3a-Krg1g" name="ArterialBlood_bc_Heart_bc" description="Neighborhood between Arterial Blood/Blood Cells and Heart/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="0_QXjFTwnEy8-V1CtkHsew" secondNeighbor="lkvUMKCxXUmEJksoilftbg">
-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="oMcIjMM7dEyChqIoXuVgjQ" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="a1xt1y1QSEmaMxv4T-34GA" name="MassTransferBloodPool2OrgRBC" description="Mass transfer from ArterialBlood: BloodCells to organ: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="BaeTfEmZ5kGHql0mPvsGBg" sourceAmount="HVsSKkWIVECLvyey2mYIPw" targetAmount="Obwdz__ceEWQHALue4zdrw" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="83Mf3RneWEGh6EspsIm3og" name="ArterialBlood_pls_Gonads_pls" description="Neighborhood between Arterial Blood/Plasma and Gonads/Plasma" mode="Logical" containerType="Other" firstNeighbor="qJqHlxhje0erBO7-fTj4-g" secondNeighbor="LjaheEHgMkKcij_K4QJW7g">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="_xVoe5kyRkyL-pBn7G1C0A" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="bcPfbtwY2UOZEo75TKRdsA" name="MassTransferBloodPool2OrgPl" description="Mass transfer from Arterial Blood: Plasma to organ: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="1ekIJ1f5PkKXXdQkacliMw" sourceAmount="n0un2GZNyUWFQsjdUS5RGA" targetAmount="7v8TrBZxj028VHiqRTbv9A" />
-                  </Children>
-                </Container>
-              </Children>
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-            <Neighborhood id="XZTlxALpjkCBBeVRbFRAMQ" name="ArterialBlood_pls_Brain_pls" description="Neighborhood between Arterial Blood/Plasma and Brain/Plasma" mode="Logical" containerType="Other" firstNeighbor="qJqHlxhje0erBO7-fTj4-g" secondNeighbor="bT3W5WSK-UqwySKFP2SkAQ">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="raPeP9iRmEW2gmPYtNUklA" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Transport id="ruB2OXmvDkWoFSntBb_e2w" name="MassTransferBloodPool2OrgPl" description="Mass transfer from Arterial Blood: Plasma to organ: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="2FQtkviBxUC80hun68JNkg" sourceAmount="n0un2GZNyUWFQsjdUS5RGA" targetAmount="rOGC7KehEkmFXF9mQPDiZQ" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="PHeQ_MfCf0OeU69SVR-prA" name="Duodenum_bc_PortalVein_bc" description="Neighborhood between Duodenum/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="TdV1_un1aESakxFEr6GkQw" secondNeighbor="V3IajphOTUWt3a2j9_LOZA">
-              <Tags>
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="V9XOaNArDUeJBaGoSOMsjg" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="qCQS5ydcoUmmmduLIMuDyQ" name="Mass transfer rate (mucosa to portal vein blood cells)" description="Mass transfer rate (mucosa to portal vein blood cells)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="_TKtQ5FSMUiH0JhO0qlXJw" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Transport id="1lko4hd3J0CtGSltCZ9ddw" name="MassTransferMucosaToPveBC" description="Mass transfer from Mucosa:Blood Cells To Portal Vein: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="mT7rZKj5Qkydo30kHywVIQ" sourceAmount="F5meuBt0ck6H-U7fLJ-DUg" targetAmount="3A4PxVITtUOpr85RBMQZlg" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="6Wzbazhxd0i5OEgx57kN1g" name="Duodenum_pls_PortalVein_pls" description="Neighborhood between Duodenum/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="5qa_dNfzPEqENSftAboAkA" secondNeighbor="-zX9e5Gif0qLF9-buV_xlA">
-              <Tags>
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="yakhAjWwNkm9gHrtW8l5oQ" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="AQpp0dMp8US2CDbXPhl2mg" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="7_quIdIey0K7HxmDN5ARzQ" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Transport id="VBNap-IHwkW0TD4WyHoctw" name="MassTransferMucosaToPvePlasma" description="Mass transfer from Mucosa:Plasma To Portal Vein: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="O0RYF4RVTUiwmsNlwc2i7Q" sourceAmount="9U0qncgJp0GzhMN51sFuvg" targetAmount="hqBDuJ9j9Eqjy73I0KZSUA" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="3ufEz4fkjUq-M8cHy0YgSQ" name="Lumen_duo_Duodenum_cell" description="Neighborhood between Lumen/Duodenum and Mucosa/Duodenum/Intracellular" mode="Logical" containerType="Other" firstNeighbor="RBDgGJ__rUCEJi-Z5h0eyg" secondNeighbor="34MfH5c9wEKhN-FvYBmvow">
-              <Tags>
-                <Tag value="Neighborhood: Duodenum / Intracellular" />
-              </Tags>
-              <Children>
-                <Container id="LzddDaGHlUu7D0Ukcm_0vg" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="mcEin6uiVUmkAAI8Y_6WOg" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Iph7YhQ5KUmsZWUX2Xf2Wg" visible="0" canBeVaried="0" />
-                    <Parameter id="9eaLnOcE9ka81etofnFZww" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="ezAHDPnckEKYf8L1jOtGfw" visible="0" canBeVaried="0" />
-                    <Parameter id="PbArjjMrkE6z8KeR8HWbKg" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="2IVWcgM31UCSVl8zMDnDhw" visible="0" canBeVaried="0" />
-                    <Parameter id="86uQ75YFrkycC2WLxv5hAw" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DNGx_vFWp0KdOb7CGcoTLQ" visible="0" canBeVaried="0" />
-                    <Parameter id="BlqVNt8Ky06WgE7oIba4RA" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="LcUCvhU3W0udtbpS1KVhEQ" visible="0" canBeVaried="0" />
-                    <Parameter id="dWZH_5UUQkSpjG375tnftw" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="VVc0X37OJkiFkhq32_OoRA" visible="0" canBeVaried="0" />
-                    <Parameter id="bNoDuoh6dke-6xrQfvkRhQ" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="u_Q4X_iktkirUBSGXEyg9g" visible="0" canBeVaried="0" />
-                    <Parameter id="JzReeS-0y0KRE4WLKq-OOA" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="kpE3uXS5zUCRkpfRlyleBQ" visible="0" canBeVaried="0" />
-                    <Parameter id="AJmNW9G8dUG06p8-9han9w" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="PEhoVdLppU-G3xULjX_71g" visible="0" canBeVaried="0" />
-                    <Parameter id="l-Q-IaeJ4EKISyNQLOxypg" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="pGvG5UNdC0Sot3_d3Qdvag" visible="0" canBeVaried="0" />
-                    <Parameter id="PTPS7Ug0SEy8IrH7nJJnaw" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="jJfeJ2YxEki9TK9XP6uUMA" visible="0" canBeVaried="0" />
-                    <Parameter id="Vw52eqg9XE-rRp41YCeJig" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="DNF0kWPUFk-rtSd0Ng1Mkw" visible="0" canBeVaried="0" />
-                    <Parameter id="bG-AobM9D0CeCGTAWWSQCw" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="qr_x2cq_Y0C6Ur-VSCP4AQ" visible="0" canBeVaried="0" />
-                    <Parameter id="s6egl4l9-0GnYBfz57cpnw" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="KQgllSQtqk2EfhX37WilDQ" visible="0" canBeVaried="0" />
-                    <Parameter id="FMrTTHpBJ0-PxeuIPHSVYw" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="aWekJ2NVAECIIbxJKJ8L5g" visible="0" canBeVaried="0" />
-                    <Parameter id="vF6C-rqwl0O-453nHy8Wcw" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="nWEfS4ktXUC6-M5u3M80Cw" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="uMAd-Vwf8UqVjuAafaZ0sA" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="yWFsmfxS1Uqt7Wa4dk5OtA" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="Cwaizj0Ffk2HRquxloL8Fg" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="gxoZyuApjEuzsuLtZuZWmQ" visible="0" canBeVaried="0" />
-                    <Parameter id="N_WHyfQgR0O1jbMcQqjAAQ" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="3xvkxp6qK06bn4DgEtYULA" visible="0" canBeVaried="0" />
-                    <Parameter id="NDbz0TBbxU2voP4kP0Ni8w" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="7NEiCDSKM0i6GhEpoWb-Mw" visible="0" canBeVaried="0" />
-                    <Parameter id="9fpo7tKULEWxB7hlyfSaSw" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="vzTIjtq1GEeaU1_8TNBl6Q" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="JzqSZmOwUU-IUpdGqglRGg" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="bOPO_JT8sEOF6PITZSGGVg" visible="0" canBeVaried="0" />
-                    <Parameter id="lAo41HaFuEayKA1EfIXEjA" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="aZYSS2yfyEqUEbGBDu38yg" visible="0" canBeVaried="0" />
-                    <Parameter id="4CWgLAZAgkG2tDtsMmAXPQ" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="XQ0ZCj09k0Ot8zIL2YDpeQ" visible="0" canBeVaried="0" />
-                    <Parameter id="Fz30pQ2BTEuxOvx1V6fouw" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="ItmP-hADIEmAqZFL21ODjw" visible="0" canBeVaried="1" />
-                    <Parameter id="NW5jnMXZtkOyO53gDOXRfQ" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="cwd2O_uC-Ui_xMEQxkKh2Q" visible="0" canBeVaried="0" />
-                    <Parameter id="5oSS086cAU6NdGZ8CGm_lw" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Co8Mz9t60UCZ20SnC9HIig" visible="0" canBeVaried="0" />
-                    <Parameter id="vEacb5DabkKvVD4cStPodg" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="NayKFXLotUmsuuhWiMUiVg" visible="0" canBeVaried="0" />
-                    <Parameter id="EdILnAZNF0i7h6P1ILFQrQ" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="0IIh6FJV0UKyrimES0f1xg" visible="0" canBeVaried="0" />
-                    <Transport id="RD7OpO4YmESaUkYTSTMadA" name="DrugAbsorption_trans" description="Drug absorption transcellular" mode="Logical" containerType="Transport" dimension="Amount per time" formula="9irwJgbWFk6VZhk0OwUqqg" sourceAmount="BaeHcf6VhUyw3ftOPt1iIg" targetAmount="OmmrIkIo20K9O_8M3GTn6Q">
-                      <Children>
-                        <Parameter id="b9Wh6VPPaUylULTPp8uGPA" name="ProcessRate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="jezBWAvkAEuYQcoMQWnoLQ" visible="0" canBeVaried="1" displayUnit="µmol/min">
-                          <Tags>
-                            <Tag value="DrugAbsorption_trans" />
-                            <Tag value="ProcessRate" />
-                            <Tag value="C1" />
-                            <Tag value="Lumen_duo_Duodenum_cell" />
-                            <Tag value="Passive" />
-                          </Tags>
-                        </Parameter>
-                      </Children>
-                    </Transport>
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="8Pi4xI9RcU6c9L8GsDG6oA" name="Lumen_duo_Duodenum_pls" description="Neighborhood between Lumen/Duodenum and Mucosa/Duodenum/Plasma" mode="Logical" containerType="Other" firstNeighbor="RBDgGJ__rUCEJi-Z5h0eyg" secondNeighbor="5qa_dNfzPEqENSftAboAkA">
-              <Tags>
-                <Tag value="Neighborhood: Duodenum / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="abCXefAUxEuW8TrNvtDC3Q" name="C1" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Parameter id="KU4xyeCAmUeliopIZSOpwA" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="ZTWtG56P2kCn9KPdhJsqJQ" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="zqnIQ8kV70qjgRDhFnwWbQ" name="Sum of active process rates" description="Sum of active process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="x6yvLBojJ0WjuJEGpQIl_g" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Parameter id="USXdO-GxQ0iTvXOGalzojA" name="Sum of passive process rates" description="Sum of passive process rates" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="7S6GOVzI2EmPL9g7hbUE9A" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                    <Transport id="CP5PZLHJ5UGE1kT2bA_Cbw" name="DrugAbsorption_para" description="Drug absorption paracellular" mode="Logical" containerType="Transport" dimension="Amount per time" formula="7ha6v5uaiEyGy1hSEvh05A" sourceAmount="BaeHcf6VhUyw3ftOPt1iIg" targetAmount="9U0qncgJp0GzhMN51sFuvg">
-                      <Children>
-                        <Parameter id="P7ZAMGIMWUyxHm8xedzXOg" name="ProcessRate" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="9GAf_iApvk-8Ls8mKBR10g" visible="0" canBeVaried="1" displayUnit="µmol/min">
-                          <Tags>
-                            <Tag value="DrugAbsorption_para" />
-                            <Tag value="ProcessRate" />
-                            <Tag value="C1" />
-                            <Tag value="Lumen_duo_Duodenum_pls" />
-                            <Tag value="Passive" />
-                          </Tags>
-                        </Parameter>
-                      </Children>
-                    </Transport>
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="SDDTF4E_ukeZLP016WlpQQ" name="ColonTransversum_cell__VenousBlood_pls" description="Neighborhood between LargeIntestine/Mucosa/ColonTransversum/Interstitial and Venous Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="uSnfTCjzEEKsrn-SJCCw0g" secondNeighbor="J2AzZMiPQUibGWyUqz4XLA">
-              <Tags>
-                <Tag value="Neighborhood: Interstitial / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="YkXZy-gk7E6pMNk7DiBM6g" name="C1" mode="Logical" containerType="Molecule" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="cj3ZeVukREaLLG38FEnmgw" name="ColonDescendens_cell__VenousBlood_pls" description="Neighborhood between LargeIntestine/Mucosa/ColonDescendens/Interstitial and Venous Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="YUV1KDlDvUS4N8X86jTR_w" secondNeighbor="J2AzZMiPQUibGWyUqz4XLA">
-              <Tags>
-                <Tag value="Neighborhood: Interstitial / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="PKiRd-XS2k2Dgn4KYU-srg" name="C1" mode="Logical" containerType="Molecule" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="1jrf_8POzUeagCpv5fG1Mg" name="ColonSigmoid_cell__VenousBlood_pls" description="Neighborhood between LargeIntestine/Mucosa/ColonSigmoid/Interstitial and Venous Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="5HpeQ-ekKkOS2la6bazFiA" secondNeighbor="J2AzZMiPQUibGWyUqz4XLA">
-              <Tags>
-                <Tag value="Neighborhood: Interstitial / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="AJ1DPMVMIEOEbf6kuTTxvw" name="C1" mode="Logical" containerType="Molecule" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="l_0o0r28u0q_ExIA5dznjw" name="Rectum_cell__VenousBlood_pls" description="Neighborhood between LargeIntestine/Mucosa/Rectum/Interstitial and Venous Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="k2lXslAcv0O9A3Owj-loLg" secondNeighbor="J2AzZMiPQUibGWyUqz4XLA">
-              <Tags>
-                <Tag value="Neighborhood: Interstitial / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="L6YGFwvFoUSzk-zIldvYLw" name="C1" mode="Logical" containerType="Molecule" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="aW2uqgvSCECXG3z2yzKCpg" name="UpperJejunum_cell__VenousBlood_pls" description="Neighborhood between SmallIntestine/Mucosa/UpperJejunum/Interstitial and Venous Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="MX7UE1AYnEeTRDJ1HM7CBg" secondNeighbor="J2AzZMiPQUibGWyUqz4XLA">
-              <Tags>
-                <Tag value="Neighborhood: Interstitial / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="H1Yj0x5xdkqvKmplP1vsnQ" name="C1" mode="Logical" containerType="Molecule" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="x2HRkuWj_kqoKAvcZf5qAA" name="ColonAscendens_cell__VenousBlood_pls" description="Neighborhood between LargeIntestine/Mucosa/ColonAscendens/Interstitial and Venous Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="uvlcQsL-GUCowlN-t4ha-g" secondNeighbor="J2AzZMiPQUibGWyUqz4XLA">
-              <Tags>
-                <Tag value="Neighborhood: Interstitial / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="CjzLecHtKkCF859PnvDLDw" name="C1" mode="Logical" containerType="Molecule" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="DWurbkPEr0Oout28flcp4g" name="LowerIleum_cell__VenousBlood_pls" description="Neighborhood between SmallIntestine/Mucosa/LowerIleum/Interstitial and Venous Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="uqiskikve0-qI31H7jOgWg" secondNeighbor="J2AzZMiPQUibGWyUqz4XLA">
-              <Tags>
-                <Tag value="Neighborhood: Interstitial / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="6ZHZuA1ns06tOOUs0rr0VA" name="C1" mode="Logical" containerType="Molecule" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="twXNNHPVYkOKQ2B5Bvx4Jg" name="UpperIleum_cell__VenousBlood_pls" description="Neighborhood between SmallIntestine/Mucosa/UpperIleum/Interstitial and Venous Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="mL_v9Y4FbUCAI1t4VRNB6g" secondNeighbor="J2AzZMiPQUibGWyUqz4XLA">
-              <Tags>
-                <Tag value="Neighborhood: Interstitial / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="EPoALHLdvUyX0TEva4H8aQ" name="C1" mode="Logical" containerType="Molecule" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="Gt__CONpF0OhEo7cJyDO8Q" name="LowerJejunum_cell__VenousBlood_pls" description="Neighborhood between SmallIntestine/Mucosa/LowerJejunum/Interstitial and Venous Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="QujFSUBKfUuVAqdGlF3CiA" secondNeighbor="J2AzZMiPQUibGWyUqz4XLA">
-              <Tags>
-                <Tag value="Neighborhood: Interstitial / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="Vk1JrbAtSUaVINro9xLpAg" name="C1" mode="Logical" containerType="Molecule" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="k8htIotSMkmnRAnMoE-Ghw" name="Duodenum_cell__VenousBlood_pls" description="Neighborhood between SmallIntestine/Mucosa/Duodenum/Interstitial and Venous Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="qdfrt7fje02lpLnQb4CGDw" secondNeighbor="J2AzZMiPQUibGWyUqz4XLA">
-              <Tags>
-                <Tag value="Neighborhood: Interstitial / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="PlXDIeeyAE2KRP9UoRv8-g" name="C1" mode="Logical" containerType="Molecule" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="9WoZcq0H0kmbVJbKkm4qAg" name="Caecum_cell__VenousBlood_pls" description="Neighborhood between LargeIntestine/Mucosa/Cecum/Interstitial and Venous Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="3hhWlW8CU02dQMHm8E1PTg" secondNeighbor="J2AzZMiPQUibGWyUqz4XLA">
-              <Tags>
-                <Tag value="Neighborhood: Interstitial / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="Zd38a35MFUCXYqu8uH7O_A" name="C1" mode="Logical" containerType="Molecule" />
-              </Children>
-            </Neighborhood>
-          </Children>
-        </Container>
-        <Container id="TXyJH4Fec0quOCxr9Lo0BQ" name="C1" icon="Drug" mode="Logical" containerType="Molecule">
-          <Children>
-            <Parameter id="LogydllwZkqTfXLPinzZLg" name="P_bc_pls_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Global" visible="0" canBeVaried="1" value="1" />
-            <Parameter id="I6yNhAeSO0eXj4gCSWFD3g" name="Intestinal permeability (paracellular)" description="Intestinal permeability via paracellular route" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" buildMode="Global" visible="1" canBeVaried="1" value="0" displayUnit="cm/min" />
-            <Parameter id="0xrwhOcQnUyNhNeu9aWEIw" name="Intestinal permeability (transcellular)" description="Intestinal permeability via transcellular route" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="FZByH7ZifECWGMDiz4CpJg" buildMode="Global" visible="1" canBeVaried="1" displayUnit="cm/min" />
-            <Parameter id="lA92jQXZoEK5svyWDnbMzg" name="Mucosa permeability scale factor (transcellular)" description="Used for scaling mucosa permeability with intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="ehgWYV_EJEWSz4KTMSaHEA" buildMode="Global" visible="0" canBeVaried="0" />
-            <Parameter id="ycec4neRz0CeGlJFpqtf2Q" name="P (plasma-&gt;blood cells)" description="Permeability from plasma to blood cells" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="ty_gSWYhkEWvqtbFzecJIQ" buildMode="Global" visible="1" canBeVaried="1" displayUnit="cm/min" />
-            <Parameter id="g4FRDFVQFUau0GflTM8uZQ" name="Default Intestinal permeability (transcellular)" description="Default Intestinal permeability via transcellular route" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="YNvMyQ1PfEaBNZlQuY5PBQ" buildMode="Global" visible="0" canBeVaried="0" displayUnit="cm/min" />
-            <Parameter id="XMaXdkmSCEeFmWyXnfR-9Q" name="P_pls_bc_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Global" visible="0" canBeVaried="1" value="1" />
-            <Parameter id="JFwn2cebVEuqaDHQxK-Ylg" name="Partition coefficient (blood cells/plasma)" description="Partition coefficient between blood cells and plasma" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="MksjF8RwYUSL0uuZ-v1Qhw" buildMode="Global" visible="1" canBeVaried="1" />
-            <Parameter id="MS710_nAy06hOa3hJqMTRg" name="P (blood cells-&gt;plasma)" description="Permeability from blood cells to plasma" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="eAgoY6lGv0GXCJvh-kiFmw" buildMode="Global" visible="1" canBeVaried="1" displayUnit="cm/min" />
-            <Parameter id="9EiZ0M7WTE2uVzqJaYm4tQ" name="Fraction unbound (plasma)" description="Fraction unbound in plasma" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" formula="XtxH8thQqkmsqNht-XoBPg" buildMode="Global" visible="1" canBeVaried="0" />
-            <Parameter id="KTFvn4BVJESgrWTNqLtyxQ" name="Blood/Plasma concentration ratio" description="Blood to plasma concentration ratio" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="QtcZRSZ5fEmZZz5_CXaeWQ" buildMode="Property" visible="1" canBeVaried="1" />
-            <Parameter id="qUQraUAhW0emgOKLqNd6Og" name="pKa_TwoAcids_0" description="Smallest acid pKa for compound with 2 acid groups" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="s0Mefd8-PkSSwCMOj0JI9A" buildMode="Property" visible="0" canBeVaried="0" />
-            <Parameter id="FC5B9QnfxkufD_SJiBQSqA" name="pKa_pH_WS_sol_K2" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="i4YC4LlNGUKarduD13pkQA" buildMode="Property" visible="0" canBeVaried="0" />
-            <Parameter id="h564Gb9OIU2JsNpQBLssmw" name="pKa_pH_WS_sol_K3" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="T5ybd5Mv2UKiQgHFcr4KMQ" buildMode="Property" visible="0" canBeVaried="0" />
-            <Parameter id="d1K--Lm_QkK4GujUyUaHnA" name="pKa_pH_WS_sol_K4" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="D41EV1kTt02fb6tvx5APZA" buildMode="Property" visible="0" canBeVaried="0" />
-            <Parameter id="rB6vbMMd80a0MyhtN94_Aw" name="pKa_pH_WS_sol_K5" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="S75mCMNVLEOYLuIYTrTUsQ" buildMode="Property" visible="0" canBeVaried="0" />
-            <Parameter id="pfrX7EhoQUmuU6c8ItG_kA" name="pKa_pH_WS_sol_K6" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="8cOwldCgCEeWOsJgKitq8A" buildMode="Property" visible="0" canBeVaried="0" />
-            <Parameter id="J452dP4k_kK3gTEEfw3a9A" name="pKa_pH_WS_sol_K7" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="w4P6yOBKR0yDEZFauB3y3Q" buildMode="Property" visible="0" canBeVaried="0" />
-            <Parameter id="9rwi62Vzak2zoLYcWB6rSw" name="pKa_pH_WS_sol_K8" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="N_UfRr5SWEy57-fkRKVixw" buildMode="Property" visible="0" canBeVaried="0" />
-            <Parameter id="timEcsywVE2_o4Re24XVCg" name="pKa_ThreeAcids_0" description="Smallest acid pKa for compound with 3 acid groups" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="6z6zpNIyZE-HyMgYgU0_ZQ" buildMode="Property" visible="0" canBeVaried="0" />
-            <Parameter id="JJqZI6mkikG5qRpHcPWB7g" name="pKa_ThreeAcids_1" description="Middle acid pKa for compound with 3 acid groups" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="p_ZTpEPPJEWfXco5ga8PAQ" buildMode="Property" visible="0" canBeVaried="0" />
-            <Parameter id="W8ptm27uaEaUe6-GkN-oWg" name="pKa_ThreeBases_1" description="Middle base pKa for compound with 3 base groups" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="26PkWqM0tUCiWogDJJAdfw" buildMode="Property" visible="0" canBeVaried="0" />
-            <Parameter id="VszokE7WI0SGUR1_-_c-Kw" name="Total oral drug mass" description="Total oral drug mass" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" buildMode="Property" visible="0" canBeVaried="0" value="0" displayUnit="µmol" />
-            <Parameter id="Ag3xoM64Z0ez-qkbLlVvBg" name="pKa_TwoAcids_1" description="Middle acid pKa for compound with 2 acid groups" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="lXgh2nTK2UyHBOncZSClnw" buildMode="Property" visible="0" canBeVaried="0" />
-            <Parameter id="rcJ27CUy406p3BiQ4UVGug" name="pKa_TwoBases_0" description="Smallest base pKa for compound with 2 base groups" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="jOMq-j8VzEexIAhS6niUSw" buildMode="Property" visible="0" canBeVaried="0" />
-            <Parameter id="4VvcZ4ezI02ZXVDB1wlmNg" name="pKa_TwoBases_1" description="Middle base pKa for compound with 2 base groups" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="IqjHNx4ZkkG_1cSG_HvBGw" buildMode="Property" visible="0" canBeVaried="0" />
-            <Parameter id="4RO2KPRbq0mEnaVRCaV9yw" name="Plasma protein binding partner" description="Plasma protein to which the drug is predominantly bound. The ontogeny of the two most important plasma protein binding partners, albumin and α1-acid glycoprotein (AGP) is available in the PK-Sim database so that the fraction unbound in plasma can be scaled to children using the ontogeny of the respective protein. If  the binding partner is neither albumin nor AGP  or if scaling to children is not of interest, the third alternative (unknown) can be used. Please note that any other ontogeny can be uploaded for the scaling to children using the Population Simulation Toolbox in MoBi" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="0" value="1" />
-            <Parameter id="Db6OsdWquEuvhd7GtATwfw" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="mYG_VbdnKkucmQfIKIeDBA" buildMode="Property" visible="0" canBeVaried="0" />
-            <Parameter id="wm5jPnKSC0yEeEQEkc8wbQ" name="pKa_ThreeBases_0" description="Smallest base pKa for compound with 3 base groups" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="vsVlFn8Gnke5hAcBu4s7tA" buildMode="Property" visible="0" canBeVaried="0" />
-            <Parameter id="eNJmgzj1zkyySNYkUJrSvQ" name="pKa_Base_1" description="Middle base pKa" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="1twxflFbwkmgOTsDPAYZNg" buildMode="Property" visible="0" canBeVaried="0" />
-            <Parameter id="xNAUIABYH0abKU-26YODbA" name="pKa_Bases_Count" description="Number of basic groups in compound" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="pmIVtDZkEkKf8McLFoFRTw" buildMode="Property" visible="0" canBeVaried="0" />
-            <Parameter id="i-9d1VEC-Uyi2UzRfHqpQw" name="base_For_KaPL_Factor" description="Supporting parameter for calculation of pKa- and pH- dependent values of KaPL" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="0" canBeVaried="0" value="20" />
-            <Parameter id="7kKOg2lNyEacOpoaypWQOw" name="base_For_logD_Factor" description="Supporting parameter for calculation of pKa- and pH- dependent logD" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="0" canBeVaried="0" value="0.001" />
-            <Parameter id="o2rhFvRx2k-WcHD8EmqASg" name="base_For_P_cell_Factor" description="Supporting parameter for calculation of pKa- and pH- dependent permeability to/from cells" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="0" canBeVaried="0" value="0.001" />
-            <Parameter id="0Lk7xgrdl0-wAj2nLOVy8A" name="BP_ALBUMIN" description="Constant for binding partner albumin" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="0" canBeVaried="0" value="1" />
-            <Parameter id="0NdfoukH70mwa4iXmCR7lA" name="pKa value 2" description="pKa value" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="1" value="0" />
-            <Parameter id="2V7b0CUJW0Oa76hp4BEF8A" name="base_For_Pint_Factor" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="0" canBeVaried="0" value="0.1" />
-            <Parameter id="HQG9CIWbS0W9YflPMOpZFw" name="Is strong base" description="Supporting parameter for partition coeffs in RR-Modell (at least one basic pKa&gt;=7)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="wqxMC7FHSk6ZnzChs_rVjQ" buildMode="Property" visible="0" canBeVaried="0" />
-            <Parameter id="Se1VvJVBa0CGuzJFM3rVTQ" name="Is triprotic acid" description="Is triprotic acid" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="cs2GyI1RhUqfhpI27ALg8w" buildMode="Property" visible="0" canBeVaried="0" />
-            <Parameter id="4fmFNiBZJkSGxhHrfbu2Ew" name="Is triprotic base" description="Is triprotic base" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="pzFR3JQu8kq3iIVFUxFSIw" buildMode="Property" visible="0" canBeVaried="0" />
-            <Parameter id="-qN_b6pnWEqVkSQnhVicXg" name="Molecular weight" description="Molecular weight" persistable="0" isFixedValue="0" dim="Molecular weight" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="1" value="4E-07" displayUnit="g/mol" />
-            <Parameter id="5RO3g3EgQUKMZRAfTXvbQA" name="Is neutral" description="Supporting parameter for partition coeffs in RR-Modell" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="qNxcuaaDqEeUpZMSXsEloA" buildMode="Property" visible="0" canBeVaried="0" />
-            <Parameter id="_oOH-82ni0q85P4alEe6cA" name="pKa value 1" description="pKa value" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="1" value="0" />
-            <Parameter id="H3Y9b7l0mkm3fP67e05vNg" name="Is monoprotic base monoprotic acid" description="Is monoprotic base monoprotic acid" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="XpOra6s9fU6Zb3dnLLpKNw" buildMode="Property" visible="0" canBeVaried="0" />
-            <Parameter id="RcZ8r_1j9kGT8prttQp6JQ" name="pKa_Acid_0" description="Smallest acid pKa" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="9qWGWfx1LE-HJd7wEU7gWA" buildMode="Property" visible="0" canBeVaried="0" />
-            <Parameter id="1K_CFU06mkCGPbobE9iDYw" name="pKa_Acid_1" description="Middle acid pKa" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="V48a2jYvVkGeBTXoaNlFAQ" buildMode="Property" visible="0" canBeVaried="0" />
-            <Parameter id="16uaUyy1CkOEukQ7UfZ5GQ" name="pKa_Acid_2" description="Largest acid pKa" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="fKj8AmTJMEqjPMaHycmlfQ" buildMode="Property" visible="0" canBeVaried="0" />
-            <Parameter id="9wCZqgNpoUGruoRKQS_udQ" name="pKa_Acids_Count" description="Number of acidic groups in compound" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="MIMzcgTPB0SAE2F2mDlong" buildMode="Property" visible="0" canBeVaried="0" />
-            <Parameter id="intA5YkSNkmhf5oGHFNflg" name="pKa_Base_0" description="Smallest base pKa" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="vYx4iwDAmU-an-pVx0lXVQ" buildMode="Property" visible="0" canBeVaried="0" />
-            <Parameter id="xm1v_X05zEaCAICS_MwdGg" name="pKa_Base_2" description="Largest base pKa" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="qGAulqDpdUuQut3VPzus6g" buildMode="Property" visible="0" canBeVaried="0" />
-            <Parameter id="h9i_TzcrCUCx0ff0T5WYjg" name="pKa_OneAcid_0" description="Smallest acid pKa for compound with 1 acid group" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="qXpnysKAm0yYOBz6d0Id0Q" buildMode="Property" visible="0" canBeVaried="0" />
-            <Parameter id="1gxtQxelO0KznTJnTxNAHg" name="pKa_OneBase_0" description="Smallest base pKa for compound with 1 base group" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="twYOLjoRCk6zcyUa5OtbZw" buildMode="Property" visible="0" canBeVaried="0" />
-            <Parameter id="KBrWPokeN0CmQHdTYTgOCA" name="pKa_pH_WS_sol_F1" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="gc3We5xZtk-d0f6uMhIxyg" buildMode="Property" visible="0" canBeVaried="0" />
-            <Parameter id="yeEP4Vv4j0Kkp8BgVSV4nA" name="pKa_pH_WS_sol_F2" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="Yq6HGneFQ0GexBDZQ4GCfw" buildMode="Property" visible="0" canBeVaried="0" />
-            <Parameter id="NcjO6XiHikW2bu8gJMyb8w" name="pKa_pH_WS_sol_F3" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CvS69ehsqEqExRoZokY2nQ" buildMode="Property" visible="0" canBeVaried="0" />
-            <Parameter id="Qyf2GDGLvEKjBY8IplKkYg" name="pKa value 0" description="pKa value" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="1" value="0" />
-            <Parameter id="tR9VYSG96k2Wa2upLtHflw" name="Effective molecular weight" description="Effective molecular weight" persistable="0" isFixedValue="0" dim="Molecular weight" quantityType="Parameter" formula="8K6i3pwGJEeL_1ZwIwSfLQ" buildMode="Property" visible="1" canBeVaried="0" displayUnit="g/mol" />
-            <Parameter id="W_skljocW02L43oFqX2jbQ" name="pKa_pH_WS_sol_K1" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="uD-Rl4F2nkelq1ZPXoQOOw" buildMode="Property" visible="0" canBeVaried="0" />
-            <Parameter id="w0zBnFMB5EOGYx_3ZTmb8w" name="BP_UNKNOWN" description="Constant for binding partner unknown" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="0" canBeVaried="0" value="2" />
-            <Parameter id="C983TG6oqEelFWNs2bEIzQ" name="Br" description="Number of bromine atoms in molecule" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="0" value="0" />
-            <Parameter id="KrNw2SNRi0KvEuI_aYZvVg" name="Calculated specific intestinal permeability (transcellular)" description="Calculated specific intestinal permeability (transcellular)" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="YdWY6LEFy0eilzVmzYcSrQ" buildMode="Global" visible="0" canBeVaried="0" displayUnit="cm/min" />
-            <Parameter id="benv0wsWgkmkwRo9oy7YGg" name="Cl" description="Number of chlorine atoms in molecule" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="0" value="0" />
-            <Parameter id="772qNP0ECUeBik_zhdh0VA" name="Compound type 0" description="Compound type (-1: acid, +1: base, 0: neutral)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="0" value="0" />
-            <Parameter id="NrBiHpt0YUKCBIL-B2DoiQ" name="Compound type 1" description="Compound type (-1: acid, +1: base, 0: neutral)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="0" value="0" />
-            <Parameter id="OTu0fF_igkSKXESpYrN8Gw" name="Compound type 2" description="Compound type (-1: acid, +1: base, 0: neutral)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="0" value="0" />
-            <Parameter id="vsO5HbD6N0mvfd1EiG4B5w" name="CT_ACID" description="Constant for compound type acid" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="0" canBeVaried="0" value="-1" />
-            <Parameter id="TqaN84oGokuWpdKc4q_X4A" name="CT_BASE" description="Constant for compound type base" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="0" canBeVaried="0" value="1" />
-            <Parameter id="JL7SG-rG5kaplbtU-IIBtw" name="Is small molecule" description="Treat compound as small molecule or not (if not, both organ specific and intestinal permeability will be set to zero)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="0" canBeVaried="0" value="1" />
-            <Parameter id="c7X0Cp8BeEi6z3LyGAiqOA" name="BP_AGP" description="Constant for binding partner α1-acid glycoprotein" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="0" canBeVaried="0" value="0" />
-            <Parameter id="2_Fuu_fq0k-5zy03XyQUCw" name="F" description="Number of fluorine atoms in molecule" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="0" value="0" />
-            <Parameter id="YwHCoHvWBUqYoeZo4-wD_A" name="Has halogens" description="Supporting parameter for compound" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="k56iilpP7EadJHMzXDwHaQ" buildMode="Property" visible="0" canBeVaried="0" />
-            <Parameter id="JJ_17RET2EuiJplJcEGW1g" name="I" description="Number of iodine atoms in molecule" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="0" value="0" />
-            <Parameter id="OGlV1B_5Qkajlfpdz5VuJA" name="Is diprotic acid" description="Is diprotic acid" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="3DmkSew8p0GGodshsXS0sQ" buildMode="Property" visible="0" canBeVaried="0" />
-            <Parameter id="heqiZ5OtPk6iVcabJryvNA" name="Is diprotic base" description="Is diprotic base" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="NEYpxLKXu0K_jNy9cG2oWw" buildMode="Property" visible="0" canBeVaried="0" />
-            <Parameter id="mKlhv7_mIkaVYtZ5TvMDgg" name="Is diprotic base monoprotic acid" description="Is diprotic base monoprotic acid" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="64jNZ-BViEmjdH_saCv85w" buildMode="Property" visible="0" canBeVaried="0" />
-            <Parameter id="UyglOKRcXkiqL331TT4X3w" name="Is floating in lumen" description="Is floating in lumen" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="0" canBeVaried="0" value="1" />
-            <Parameter id="frk_tSYdiE-MJZx2-QivEw" name="Is monoprotic acid" description="Is monoprotic acid" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="xUOQ010TDEuL3_OxNUkCYg" buildMode="Property" visible="0" canBeVaried="0" />
-            <Parameter id="sIq0mZmPE0OiD5HKARWwnQ" name="Is monoprotic base" description="Is monoprotic base" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="ky6GI8RtoUyjMT14nNjLNg" buildMode="Property" visible="0" canBeVaried="0" />
-            <Parameter id="-j26arafmUCuv76Z4AHYyw" name="Is monoprotic base diprotic acid" description="Is monoprotic base diprotic acid" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="MC6b64t5S0uFTuK7ry0LRg" buildMode="Property" visible="0" canBeVaried="0" />
-            <Parameter id="retZN1skfkmmU71t0IUGRQ" name="CT_NEUTRAL" description="Constant for compound type neutral" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="0" canBeVaried="0" value="0" />
-            <Parameter id="AYfWt72zE0aShQTh3cGP1Q" name="Lipophilicity" description="Model dependent lipophilicity measure: LogMA / LogP / ..." persistable="0" isFixedValue="0" dim="Log Units" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="1" value="3" displayUnit="Log Units" />
-            <Parameter id="Dl8cRvetDEGDhOvriOA8Qw" name="Fraction unbound (plasma, reference value)" description="Fraction unbound in plasma of the reference individual, i.e. in the case of human typically an average healthy adult. This reference value can be scaled to children based on the ontogeny of the respective plasma protein and/or in diseased subjects using the plasma protein scale factor defined in the individual" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="1" value="0.11" />
-            <Parameter id="xL-Tmd9DDUey5e4DIQQIsw" name="Solubility at reference pH" description="Solubility at reference pH" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="1" value="1.2E-05" displayUnit="mg/l" />
-            <Parameter id="sWzhfkA4qUeDIhrADBjFVQ" name="Reference pH" description="Reference pH" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="1" value="7" />
-            <Parameter id="Y2JnH2j-i0-DxHKklzEGlw" name="Solubility gain per charge" description="Supporting parameter for calculation of pKa- and pH- dependent values of intestinal solubilty" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="0" value="1000" />
-            <Parameter id="09VBh4lYrUyAQhVGx0nEkQ" name="Permeability" description="Permeability" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="vi--TMmPkkeUzIRaAri-ew" buildMode="Property" visible="1" canBeVaried="1" displayUnit="cm/min" />
-            <Parameter id="ve9kBNCZ5UWTYGznt7mZFg" name="Specific intestinal permeability (transcellular)" description="Specific intestinal permeability (transcellular)" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" formula="YdWY6LEFy0eilzVmzYcSrQ" buildMode="Property" visible="1" canBeVaried="1" displayUnit="cm/min" />
-            <Parameter id="8TziOU_OZ0aGPPDePqRwEw" name="Partition coefficient (water/protein)" description="Partition coefficient water to protein" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="SfGHNlQbkUiOXDevaYXKqw" buildMode="Property" visible="1" canBeVaried="1" />
-            <Parameter id="z_3i_pUWh0Wmy6ZwJhO6PQ" name="Treat precipitated drug as" description="Treat precipitated drug as either soluble or insoluble" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="1" value="1" />
-            <Parameter id="bQldcok2lEq9Md6jb9u6Ww" name="Aqueous diffusion coefficient" description="Aqueous diffusion coefficient&#xA;of the drug" persistable="0" isFixedValue="0" dim="Diffusion coefficient" quantityType="Parameter" formula="7qblC70bT0iHuCAviOoS6A" buildMode="Property" visible="1" canBeVaried="1" displayUnit="cm²/min" />
-            <Parameter id="xlCpL7JXQkOy7Mg3Ncxx2g" name="Density (drug)" description="Density of drug material" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="1" value="1" displayUnit="g/cm³" />
-            <Parameter id="vmGA9j5wXU6H9ToIMY9isA" name="Immediately dissolve particles smaller than" description="Threshold for the particle radius of immediate dissolution" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="1" value="1E-07" displayUnit="µm" />
-            <Parameter id="MUJhg6pJMkGRHWNlE29NNg" name="Radius (solute)" description="Solute radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" formula="mglf557pEkW4PikU0-Ku-A" buildMode="Property" visible="1" canBeVaried="1" displayUnit="µm" />
-            <Parameter id="eX_UeuoTNE2heFd2jgL22Q" name="Kd (FcRn) in endosomal space" description="Dissociation constant of drug for binding to FcRn in endosomal space" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="0" value="999999" displayUnit="µmol/l" />
-            <Parameter id="Pexe2lY7cEK5df96McirLw" name="Kd (FcRn) in plasma/interstitial" description="Dissociation constant of drug for binding to FcRn in plasma/interstitial space. For monoclonal antibodies the binding to FcRn in neutral environment (plasma and interstitial space) is generally very weak or not detectable. In this case the high default value for Kd(FcRn) in plasma/interstitial can be kept." persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="0" value="999999" displayUnit="µmol/l" />
-            <Parameter id="691CabgEGEygS9BoRoRpsg" name="kass (FcRn)" description="Association constant of drug for binding to FcRn" persistable="0" isFixedValue="0" dim="Second order rate constant" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="0" value="60" displayUnit="l/µmol/min" />
-            <Parameter id="jn8Z5pk-WEmozw0laLOqbA" name="Use pH- and pKa-dependent penalty factor for charged molecule fraction" description="Penalty factor for charged molecule fraction is used for &quot;Intestinal permeability (transcellular)&quot; only" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" buildMode="Property" visible="1" canBeVaried="1" value="0" />
-          </Children>
-        </Container>
-        <EventGroup id="Tt_HXMXRakKzJ0heZDKa1A" name="Applications" icon="Applications" mode="Logical" containerType="Other">
-          <Children>
-            <EventGroup id="Q6fnrU36sEWb2oku-bSURA" name="Particles" icon="Formulation" mode="Logical" containerType="Other">
-              <Children>
-                <Parameter id="jvIWJS_AREqJokOJKvQoIA" name="Thickness (unstirred water layer)" description="Thickness of unstirred water layer" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0002" displayUnit="µm" />
-                <Parameter id="AdJPCiouCE6V-zVrER1hSw" name="Particle size distribution" description="Particle size distribution" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0" />
-                <Parameter id="OgPheTOUcE2ek2YJuQQN8Q" name="Type of particle size distribution" description="Type of particle size distribution (monodisperse vs. polydisperse)" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0" />
-                <Parameter id="Vkrw8GNeoUCIAB-SUJj_mw" name="Particle radius (mean)" description="Mean particle radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0001" displayUnit="µm" />
-                <Parameter id="X3J4FPQOAU2_lLHREdMLcA" name="Particle radius (SD)" description="Standard deviation of particle radius distribution" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="3E-05" displayUnit="µm" />
-                <Parameter id="tXjaaAy690Cts1-etMJD7Q" name="Particle radius (geomean)" description="Geometric mean of particle radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.0001" displayUnit="µm" />
-                <Parameter id="V3uEpxOwhkay3u56eosiGw" name="Coefficient of variation" description="Coefficient of variation " persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="1.5" />
-                <Parameter id="ryS9KJE_Ek2qw_NLSMkv1g" name="Number of bins" description="Number of bins for particle radius distribution" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="11" />
-                <Parameter id="oejNDwXaLk2S8HVKvsdQZw" name="Particle radius (min)" description="Lower bound of particle radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="1E-05" displayUnit="µm" />
-                <Parameter id="0gtSjqF0mky88RWD6MRsUw" name="Particle radius (max)" description="Upper bound of particle radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="1" value="0.00019" displayUnit="µm" />
-                <EventGroup id="7ArjmgwzEEmpw1aBKdz-_Q" name="Application_1" icon="Oral" mode="Logical" containerType="Other" eventGroupType="Oral">
-                  <Tags>
-                    <Tag value="ParticlesApplication_1_Bins" />
-                    <Tag value="Application" />
-                    <Tag value="Application_1" />
-                    <Tag value="ApplicationRoot" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="-FYLieHBdky6kiIneOLSTQ" name="Tablet time delay factor" description="Tablet time delay factor" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="1" value="0.2" />
-                    <Parameter id="dBpPYlxgikC1ZZtvTUerXw" name="Tablet_Location_sto" description="Tablet location in Stomach" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="7dHc1Kvd5E-eocQWfKPXJg" visible="0" canBeVaried="0" />
-                    <Parameter id="3gPmlzzzxEGTcETSrwlt5w" name="Tablet_Location_rect" description="Tablet location in Rectum" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="fmN2qqsxFk2VclxZLtP17g" visible="0" canBeVaried="0" />
-                    <Parameter id="JIdSzwd2i0y4gcYYh7LKGA" name="Tablet_Location_uil" description="Tablet location in Upper Ileum" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="4m3NoE9vCEmAwNyp7KnTTA" visible="0" canBeVaried="0" />
-                    <Parameter id="KvJhFMtXgkes6LbsvMxT1Q" name="Tablet_Location_lje" description="Tablet location in Lower Jejunum" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="HjaREld9AUCMQ0VKpOPKeQ" visible="0" canBeVaried="0" />
-                    <Parameter id="PPffe3wKJ0O14em-uZDwOg" name="Tablet_Location_lil" description="Tablet location in Lower Ileum" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="VdxpOVJDDkO24wRq4Vef9w" visible="0" canBeVaried="0" />
-                    <Parameter id="G8ekW7qUu0e-75Xvsa0qTg" name="Tablet_Location_cae" description="Tablet location in Cecum" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CaC1pURvuECHBRnArrMPug" visible="0" canBeVaried="0" />
-                    <Parameter id="kFMSzXh53Eq5ve_e8DyWew" name="Tablet_Location_coltrans" description="Tablet location in Colon Transversum" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="lN5d393rDEKRDU_K2aq6EA" visible="0" canBeVaried="0" />
-                    <Parameter id="mP11DFxLE0SEf1mhJW_7sQ" name="Tablet_Location_colasc" description="Tablet location in Colon Ascendens" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="9ljn6PbEOUy1bfwxfP5zVw" visible="0" canBeVaried="0" />
-                    <Parameter id="QpmJK2PSWUiilRkBheCHgw" name="Tablet_Location_duo" description="Tablet location in Duodenum" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="7CbcUfkiwkKBiATEn1jy0Q" visible="0" canBeVaried="0" />
-                    <Parameter id="57hdERCdjUagp6JC1POPFA" name="Tablet_Location_colsigm" description="Tablet location in Colon Sigmoid" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="HTLMuURWaUy-Is9_13axmA" visible="0" canBeVaried="0" />
-                    <Parameter id="1rZHfsJnx0aQVz7uav5JTQ" name="Tablet_Location_coldesc" description="Tablet location in Colon Descendens" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="RUv1hNQbwU6ST8UCe_UJqw" visible="0" canBeVaried="0" />
-                    <Parameter id="MCrWQEMO9kCxBEPbiMHW-Q" name="Tablet_Location" description="Tablet location in lumen" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="0" rHSFormula="pGh2_eKzOUq5ZCJzSOmU1w" value="1.99" />
-                    <Parameter id="Ze4__aFGnkaNFpmVkMRLWw" name="TabletIsActive" description="Enables/disables all tablet interactions" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" visible="0" canBeVaried="0" value="0" />
-                    <Parameter id="84b7Ml5dXkGLgVh6jLncIw" name="Tablet_Location_uje" description="Tablet location in Upper Jejunum" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="CVWZpZrcDkKBPXbSLlkIiQ" visible="0" canBeVaried="0" />
-                    <Event id="ZpKDhP3580uuH8SwZRqDtw" name="Application_StartEvent" description="Start event for application" mode="Logical" containerType="Other" dimension="Dimensionless" formula="4C4y9XqRwUCZ_p3GXWe9bQ" oneTime="1">
-                      <Children>
-                        <EventAssignment id="kA_GKLp42UW9bD-IEL2fkA" name="Assignment_1" dimension="Amount" formula="gilTTxophUWZkDTPj-ZzDg" useAsValue="1" changedEntity="VszokE7WI0SGUR1_-_c-Kw">
-                          <ObjectPath path="5" />
-                        </EventAssignment>
-                        <EventAssignment id="r8vPbdyKNEKl7WkCeEBRHQ" name="Assignment_2" dimension="Dimensionless" formula="V6xzsrMBLUmpfDiG5wEIqw" useAsValue="1" changedEntity="Ze4__aFGnkaNFpmVkMRLWw">
-                          <ObjectPath path="6" />
-                        </EventAssignment>
-                        <EventAssignment id="PKuCi-Gto0GnxZPajpZWjg" name="Assignment_3" dimension="Dimensionless" formula="CI91X9EF0EK0cw0_UYFFMQ" useAsValue="1" changedEntity="2TOFTU6KxkyZgjM29fS9jw">
-                          <ObjectPath path="3" />
-                        </EventAssignment>
-                        <EventAssignment id="pzaGSKe5R0qYpNj6Ps3nYA" name="Assignment_4" dimension="Volume" formula="bVqz9OGN2kO7caswGP81LA" useAsValue="1" changedEntity="8delt8xpp0at7I-zDeOgBg">
-                          <ObjectPath path="0" />
-                        </EventAssignment>
-                      </Children>
-                    </Event>
-                    <Event id="BcBuyjdookqWVXEnoo-_DA" name="Application_StopEvent" description="Stop event for application" mode="Logical" containerType="Other" dimension="Dimensionless" formula="WFOJB_T6VUKxvqPistuwDA" oneTime="1">
-                      <Children>
-                        <EventAssignment id="-jRrFYYp-EaQD4j7MYhmKA" name="Assignment_1" dimension="Dimensionless" formula="U_dm9YBhhEWJjEMpOR0ltw" useAsValue="0" changedEntity="Ze4__aFGnkaNFpmVkMRLWw">
-                          <ObjectPath path="6" />
-                        </EventAssignment>
-                      </Children>
-                    </Event>
-                    <Container id="72b9bywlX0OqKX2YFw_u2g" name="ProtocolSchemaItem" description="Protocol Schema Item" mode="Logical" containerType="Other">
-                      <Tags>
-                        <Tag value="Application" />
-                        <Tag value="Application_1" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="EmZ--yzzCE67OVFCI7-3Rg" name="Start time" description="Start time of application" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" visible="1" canBeVaried="1" value="0" displayUnit="h" />
-                        <Parameter id="J9ogs0AJ6EGV4Pc3pE1acA" name="DosePerBodyWeight" description="Dose" persistable="0" isFixedValue="0" dim="Dose per body weight" quantityType="Parameter" visible="1" canBeVaried="1" value="1E-06" displayUnit="mg/kg" />
-                        <Parameter id="Epv0fkB6UE6vH_33AsOcqg" name="DrugMass" description="Drug mass of application" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" formula="HDbBI1HPIEe9_d0TGTcDdA" visible="0" canBeVaried="1" displayUnit="µmol" />
-                        <Parameter id="LcJJOdD1CUChFG59Y4-0vQ" name="Dose" description="Dose" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" formula="zgtxNdadf0C8CiYnebL-aA" visible="0" canBeVaried="1" displayUnit="mg" />
-                        <Parameter id="wE4BCsOKgEKDdKJdHGGBng" name="Volume of water/body weight" description="Volume of water per body weight co-administered with the drug" persistable="0" isFixedValue="0" dim="Volume per body weight" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0035" displayUnit="ml/kg" />
-                        <Parameter id="SFZ8vXR8_EG2YGQGSxeO0w" name="Amount of water" description="Amount of water" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" formula="U1qDDxPkTkC0dLz3W7AUGQ" visible="0" canBeVaried="1" displayUnit="l" />
-                      </Children>
-                    </Container>
-                    <EventGroup id="YoIzhlb_fkaJBnys951-BQ" name="ParticleBin_1" description="Particle Bin #1" mode="Logical" containerType="Other">
-                      <Tags>
-                        <Tag value="ParticleBin" />
-                        <Tag value="Application" />
-                        <Tag value="Application_1" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="-OHYqvoo9kauHvOZGxKhqQ" name="Number_Of_Particles_Factor" description="Factor for number of particles (depends on particle radius distribution)" persistable="0" isFixedValue="0" dim="Inversed volume" quantityType="Parameter" visible="0" canBeVaried="0" value="238732414637.843" displayUnit="1/l" />
-                        <Parameter id="pElH1EdPqEea7lUHhn26Sg" name="Fraction solid" description="Fraction of solid drug" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" formula="69IHxpkcJ06eNRAwGfCOMQ" visible="0" canBeVaried="0" />
-                        <Parameter id="vmQiR5Pvl0-28VqeZhHVTg" name="Fraction insoluble" description="Fraction of insoluble drug" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" formula="7dFuMWyHAEqLByWfcanYPg" visible="0" canBeVaried="0" />
-                        <Parameter id="IAT5oHrot0OtwmeeqWgItw" name="Fraction dissolved" description="Fraction of dissolved drug" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" formula="mlkz5cnvgkOAKU6R3kIODg" visible="0" canBeVaried="0" />
-                        <Parameter id="DZ-YCunzPk2zTVrBv0nyAw" name="DrugMass of particle bin" description="Drug mass of a single particle bin" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" formula="YfIS5UyBtE2IIcRrCeh80A" visible="0" canBeVaried="1" displayUnit="µmol" />
-                        <Parameter id="4AwL0HdGLk6mzKlLz9YBLA" name="Number of particles" description="Number of drug particles in one particle bin" persistable="0" isFixedValue="0" dim="Dimensionless" quantityType="Parameter" formula="z2J6dWxta0iiGDkEd_S2aA" visible="1" canBeVaried="1" />
-                        <Parameter id="lRQ74rNDmEixJSvYH2K9Dg" name="Particle radius (at t=0)" description="Particle radius at t=0" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="1" canBeVaried="1" value="0.0001" displayUnit="µm" />
-                        <Parameter id="QhZHwKrA_k2m_0n_uWN6Ew" name="Particle radius" description="Particle radius" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" visible="0" canBeVaried="0" value="0" displayUnit="µm" />
-                        <Event id="4sF11y6_WkeeirPkq-ezEw" name="ParticleBinDissolvedEvent" description="ParticleBinDissolvedEvent" mode="Logical" containerType="Other" dimension="Dimensionless" formula="0mq5QPRtfkeXCvOEzwQHiQ" oneTime="1">
-                          <Children>
-                            <EventAssignment id="x6Q2lnaKIEKw4lhJ1bcS1A" name="Assignment_1" dimension="Amount" formula="qdDQ225oZUGWetmSxuULXA" useAsValue="1" changedEntity="Qnj6YM6q_kSvSvGmWycE8g">
-                              <ObjectPath path="7" />
-                            </EventAssignment>
-                            <EventAssignment id="Vre4DoBbFEi7wl3zFDeIVg" name="Assignment_2" dimension="Amount" formula="ujf29U82iUGEOHOj9U_olA" useAsValue="1" changedEntity="mgzsCzTwXkGLoEv-ZBAnNQ">
-                              <ObjectPath path="8" />
-                            </EventAssignment>
-                            <EventAssignment id="dRmvXsGkh0GzxeqTDOHc0g" name="Assignment_3" dimension="Amount" formula="UCihUDTvPUeDtOf0DHgXoQ" useAsValue="1" changedEntity="yiZ323gtz0WRt_37u8tDPQ">
-                              <ObjectPath path="9" />
-                            </EventAssignment>
-                            <EventAssignment id="5cO1NE8S3ECwhCIxrnKVKg" name="Assignment_4" dimension="Amount" formula="s69aiGv2j0GcXdkvL2x0tQ" useAsValue="1" changedEntity="jIGCgtwn-U2Oqcv2W4G-ZQ">
-                              <ObjectPath path="10" />
-                            </EventAssignment>
-                            <EventAssignment id="iAMTtVYwSEubu_OMDgHWaw" name="Assignment_5" dimension="Amount" formula="zK8sQNqfo0SmsxOQVBrqFQ" useAsValue="1" changedEntity="B3i4ajvEPkWwF-QJhPT-RA">
-                              <ObjectPath path="11" />
-                            </EventAssignment>
-                            <EventAssignment id="_5G4vuZ9ckeBER09YFlEgg" name="Assignment_6" dimension="Amount" formula="H3G1HmtyZE2sNyn_2BPQ2g" useAsValue="1" changedEntity="BaeHcf6VhUyw3ftOPt1iIg">
-                              <ObjectPath path="12" />
-                            </EventAssignment>
-                            <EventAssignment id="VTQXG1rJl0y28MVR5HhVsQ" name="Assignment_7" dimension="Amount" formula="DtDDG--aY0erWl5Uaqe3fg" useAsValue="1" changedEntity="yw7rzbgJB0-l91_K8hz0sQ">
-                              <ObjectPath path="13" />
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-                            <EventAssignment id="mhUkcksyeE6iC21KdXMcBg" name="Assignment_8" dimension="Amount" formula="Q1sfQzrvpkaDRJW2YsCxTw" useAsValue="1" changedEntity="Cuam5DbmZ0uqXwc9apFicg">
-                              <ObjectPath path="14" />
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-                            <EventAssignment id="-rf3XcWRTkO3NB_GNJKjOQ" name="Assignment_9" dimension="Amount" formula="yjJYxfWaCEeiBHAju5ieFQ" useAsValue="1" changedEntity="2kdpKYdY3EeBvJPRNS1TEg">
-                              <ObjectPath path="15" />
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-                            <EventAssignment id="93FK2SudkkaI0MQdIHWm9g" name="Assignment_10" dimension="Amount" formula="3PoD-SMsPkynzN0rdtRsGQ" useAsValue="1" changedEntity="r-aj2d-zBEqErgcKF5e5cw">
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-                            <EventAssignment id="bUj4FPinQUScuspSmHOmtw" name="Assignment_11" dimension="Amount" formula="ba2bazbLTEyyjXgsdQ9Kpg" useAsValue="1" changedEntity="xrlOSQNSBk-WGtZ7E-tEYw">
-                              <ObjectPath path="17" />
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-                            <EventAssignment id="kaYT0F3H2U6tV2wqncNuOw" name="Assignment_12" dimension="Amount" formula="pHJ_EnTTzEeB1HQlLwGb7Q" useAsValue="1" changedEntity="V3v2rXqlRkujCVZ10rY3Ew">
-                              <ObjectPath path="18" />
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-                            <EventAssignment id="pVKCs57Bx02oztNqq1qu8Q" name="Assignment_13" dimension="Dimensionless" formula="1i5wXRpt6UKJZh6A7fIBFw" useAsValue="1" changedEntity="qDHwaA9ork6sAO1_XZF3XA">
-                              <ObjectPath path="19" />
-                            </EventAssignment>
-                          </Children>
-                        </Event>
-                        <Container id="_B99udIih0GjHfLBejwghg" name="InsolubleDrug" description="Insoluble Drug during particle dissolution" mode="Logical" containerType="Other">
-                          <Tags>
-                            <Tag value="InsolubleDrug" />
-                            <Tag value="Application" />
-                            <Tag value="Application_1" />
-                          </Tags>
-                          <Children>
-                            <MoleculeAmount id="Cl1DWJlu4E6bdjBOMOGfYQ" name="C1" icon="Drug" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" formula="Q_C8Zi7YPkKusiBZh2GpTQ" mode="Logical" scaleFactor="1" displayUnit="µmol">
-                              <Children>
-                                <Parameter id="FEPbFL75FUyLVORfVqBI4Q" name="Concentration" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="MtbnZoefikm6xL8xEps8Rg" visible="0" canBeVaried="0" />
-                                <Transport id="B5kePIXEkUyCF3b5IecgKg" name="ParticlesPrecipitationCaecum" description="Particles precipitation in Cecum" mode="Logical" containerType="Transport" dimension="Amount per time" formula="1VGEpHrXOE2lrcAvRiBqTQ" sourceAmount="Cl1DWJlu4E6bdjBOMOGfYQ" targetAmount="Qnj6YM6q_kSvSvGmWycE8g">
-                                  <Children>
-                                    <Parameter id="CLqJ-VAEbEugAS2BpGfBDA" name="Precipitation rate of the tablet" description="Precipitation rate of the tablet" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="LW98m6gCCU2qzB0kZ_3PtQ" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                                  </Children>
-                                </Transport>
-                                <Transport id="2WYhbcGi3UivvJvRrqxLEA" name="ParticlesPrecipitationColonAscendens" description="Particles precipitation in ColonAscendens" mode="Logical" containerType="Transport" dimension="Amount per time" formula="ki0QI1T8JECMHgfdgfZuiA" sourceAmount="Cl1DWJlu4E6bdjBOMOGfYQ" targetAmount="mgzsCzTwXkGLoEv-ZBAnNQ">
-                                  <Children>
-                                    <Parameter id="U40cONLEuEOcP1paUgwPOA" name="Precipitation rate of the tablet" description="Precipitation rate of the tablet" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="icNAdc6PvE2Vm0cY9irb9w" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                                  </Children>
-                                </Transport>
-                                <Transport id="O73kK392VkGF-nDqXgvrRQ" name="ParticlesPrecipitationColonDescendens" description="Particles precipitation in ColonDescendens" mode="Logical" containerType="Transport" dimension="Amount per time" formula="pbhfy9r9zkih9PB8CrqxsQ" sourceAmount="Cl1DWJlu4E6bdjBOMOGfYQ" targetAmount="yiZ323gtz0WRt_37u8tDPQ">
-                                  <Children>
-                                    <Parameter id="ipARTe8C_0SpQ_x2eqaGyQ" name="Precipitation rate of the tablet" description="Precipitation rate of the tablet" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="0UuF8eufMkOx4eNUP-DcFA" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                                  </Children>
-                                </Transport>
-                                <Transport id="Cim3oL9sIkKrTZd4Jjb8oA" name="ParticlesPrecipitationColonSigmoid" description="Particles precipitation in ColonSigmoid" mode="Logical" containerType="Transport" dimension="Amount per time" formula="H0N6kS_RlE2x0n47Y7FcvA" sourceAmount="Cl1DWJlu4E6bdjBOMOGfYQ" targetAmount="jIGCgtwn-U2Oqcv2W4G-ZQ">
-                                  <Children>
-                                    <Parameter id="OLtntt8QBkqNKGs6QQn1JA" name="Precipitation rate of the tablet" description="Precipitation rate of the tablet" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="pcbt9b0M7k-M4kkruGv3qA" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                                  </Children>
-                                </Transport>
-                                <Transport id="Eq1sUqqNz0C02JPqNkWtOA" name="ParticlesPrecipitationColonTransversum" description="Particles precipitation in ColonTransversum" mode="Logical" containerType="Transport" dimension="Amount per time" formula="4PFHwE7snEGBFjsXCFtzGg" sourceAmount="Cl1DWJlu4E6bdjBOMOGfYQ" targetAmount="B3i4ajvEPkWwF-QJhPT-RA">
-                                  <Children>
-                                    <Parameter id="Qi2V6Wi3fEyqYKrryn6nDA" name="Precipitation rate of the tablet" description="Precipitation rate of the tablet" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="gaMHxl2MP0-uTOKsZhZHkg" visible="0" canBeVaried="0" displayUnit="µmol/min" />
-                                  </Children>
-                                </Transport>
-                                <Transport id="V2oefvqBUUasF-gdtxqnLQ" name="ParticlesPrecipitationDuodenum" description="Particles precipitation in Duodenum" mode="Logical" containerType="Transport" dimension="Amount per time" formula="icBXezPnhEmFcSEQds7Hwg" sourceAmount="Cl1DWJlu4E6bdjBOMOGfYQ" targetAmount="BaeHcf6VhUyw3ftOPt1iIg">
-                                  <Children>
-                                    <Parameter id="3R55Im7wHUKa3W_lUZ7TxQ" name="Precipitation rate of the tablet" description="Precipitation rate of the tablet" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" formula="k-cstTYLH02gY7UVuVNU1g" visible="0" canBeVaried="0" displayUnit="µmol/min" />
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-        <Map s="..|Specific blood flow rate" id="200" />
-        <Map s="Qspec" id="201" />
-        <Map s="Flow per weight organ" id="202" />
-        <Map s="..|Weight (tissue)" id="203" />
-        <Map s="Weight" id="204" />
-        <Map s="S1|Organism|Thickness (endothelium)" id="205" />
-        <Map s="d_endo" id="206" />
-        <Map s="S1|Neighborhoods|Bone_pls_Bone_int|Surface area (plasma/interstitial)" id="207" />
-        <Map s="SA_pls_int" id="208" />
-        <Map s="Area" id="209" />
-        <Map s="..|Fraction interstitial" id="210" />
-        <Map s="f_int" id="211" />
-        <Map s="..|Fraction vascular" id="212" />
-        <Map s="V_org" id="213" />
-        <Map s="..|..|Fraction interstitial" id="214" />
-        <Map s="S1|Organism|pH (interstitial)" id="215" />
-        <Map s="pH_int" id="216" />
-        <Map s="S1|Neighborhoods|Bone_int_Bone_cell|C1|Partition coefficient (interstitial/water)" id="217" />
-        <Map s="K_water_int" id="218" />
-        <Map s="..|..|Fraction intracellular" id="219" />
-        <Map s="f_cell" id="220" />
-        <Map s="S1|Neighborhoods|Bone_int_Bone_cell|C1|Partition coefficient (intracellular/water)" id="221" />
-        <Map s="K_water_cell" id="222" />
-        <Map s="..|..|Interstitial|C1|Concentration" id="223" />
-        <Map s="C_int" id="224" />
-        <Map s="..|..|Interstitial|C1|Partition coefficient (water/container)" id="225" />
-        <Map s="..|..|Intracellular|C1|Concentration" id="226" />
-        <Map s="C_cell" id="227" />
-        <Map s="..|..|Intracellular|C1|Partition coefficient (water/container)" id="228" />
-        <Map s="S1|Neighborhoods|Brain_pls_Brain_int|Surface area (plasma/interstitial)" id="229" />
-        <Map s="S1|Neighborhoods|Brain_int_Brain_cell|C1|Partition coefficient (interstitial/water)" id="230" />
-        <Map s="S1|Neighborhoods|Brain_int_Brain_cell|C1|Partition coefficient (intracellular/water)" id="231" />
-        <Map s="S1|Neighborhoods|Fat_pls_Fat_int|Surface area (plasma/interstitial)" id="232" />
-        <Map s="GeometricDeviation" id="233" />
-        <Map s="S1|Neighborhoods|Fat_int_Fat_cell|C1|Partition coefficient (interstitial/water)" id="234" />
-        <Map s="S1|Neighborhoods|Fat_int_Fat_cell|C1|Partition coefficient (intracellular/water)" id="235" />
-        <Map s="S1|Neighborhoods|Gonads_pls_Gonads_int|Surface area (plasma/interstitial)" id="236" />
-        <Map s="S1|Neighborhoods|Gonads_int_Gonads_cell|C1|Partition coefficient (interstitial/water)" id="237" />
-        <Map s="S1|Neighborhoods|Gonads_int_Gonads_cell|C1|Partition coefficient (intracellular/water)" id="238" />
-        <Map s="S1|Neighborhoods|Heart_pls_Heart_int|Surface area (plasma/interstitial)" id="239" />
-        <Map s="S1|Neighborhoods|Heart_int_Heart_cell|C1|Partition coefficient (interstitial/water)" id="240" />
-        <Map s="S1|Neighborhoods|Heart_int_Heart_cell|C1|Partition coefficient (intracellular/water)" id="241" />
-        <Map s="S1|Neighborhoods|Kidney_pls_Kidney_int|Surface area (plasma/interstitial)" id="242" />
-        <Map s="S1|Organism|Estimated gestational age" id="243" />
-        <Map s="PMA" id="244" />
-        <Map s="S1|Organism|Kidney|fGFRpremat" id="245" />
-        <Map s="GFR_premat" id="246" />
-        <Map s="S1|Organism|Kidney|GFRmat" id="247" />
-        <Map s="GFR_mat" id="248" />
-        <Map s="Flow" id="249" />
-        <Map s="S1|Organism|Kidney|Hill coefficient for GFR" id="250" />
-        <Map s="Hill" id="251" />
-        <Map s="S1|Organism|Kidney|TM50 for GFR" id="252" />
-        <Map s="TM50" id="253" />
-        <Map s="S1|Organism|Kidney|Volume (standard kidney)" id="254" />
-        <Map s="V_kid_std" id="255" />
-        <Map s="S1|Neighborhoods|Kidney_int_Kidney_cell|C1|Partition coefficient (interstitial/water)" id="256" />
-        <Map s="S1|Neighborhoods|Kidney_int_Kidney_cell|C1|Partition coefficient (intracellular/water)" id="257" />
-        <Map s="..|Distal radius" id="258" />
-        <Map s="r2" id="259" />
-        <Map s="..|Length" id="260" />
-        <Map s="L" id="261" />
-        <Map s="..|Proximal radius" id="262" />
-        <Map s="r1" id="263" />
-        <Map s="..|Geometric surface area" id="264" />
-        <Map s="..|Thickness of gut wall" id="265" />
-        <Map s="d" id="266" />
-        <Map s="..|pH in fasted state" id="267" />
-        <Map s="pH_fasted" id="268" />
-        <Map s="..|Fractional steady state fill level" id="269" />
-        <Map s="SteadyStateFillLevel" id="270" />
-        <Map s="..|Inverse rate of inflow of liquid into stomach" id="271" />
-        <Map s="StomachInflowTime" id="272" />
-        <Map s="..|Fraction of geometric volume filled with liquid" id="273" />
-        <Map s="FillLevel" id="274" />
-        <Map s="..|Liquid" id="275" />
-        <Map s="Liquid" id="276" />
-        <Map s="..|Gastric emptying time" id="277" />
-        <Map s="GET" id="278" />
-        <Map s="..|FillLevelFlag" id="279" />
-        <Map s="FillLevelFlag" id="280" />
-        <Map s="..|Liquid transfer rate" id="281" />
-        <Map s="LT_sto" id="282" />
-        <Map s="..|Secretion of liquid" id="283" />
-        <Map s="Inflow" id="284" />
-        <Map s="..|..|OralApplicationsEnabled" id="285" />
-        <Map s="OralApplicationsEnabled" id="286" />
-        <Map s="..|Intestinal transit rate (absolute)" id="287" />
-        <Map s="w" id="288" />
-        <Map s="..|..|Duodenum|FillLevelFlag" id="289" />
-        <Map s="FillLevelFlagNext" id="290" />
-        <Map s="..|pKa_pH_WS_lum_F1" id="291" />
-        <Map s="F1" id="292" />
-        <Map s="..|pKa_pH_WS_lum_F2" id="293" />
-        <Map s="F2" id="294" />
-        <Map s="..|pKa_pH_WS_lum_F3" id="295" />
-        <Map s="F3" id="296" />
-        <Map s="S1|C1|Compound type 2" id="297" />
-        <Map s="CT2" id="298" />
-        <Map s="S1|C1|CT_NEUTRAL" id="299" />
-        <Map s="CT_NEUTRAL" id="300" />
-        <Map s="S1|C1|pKa value 2" id="301" />
-        <Map s="pKa_2" id="302" />
-        <Map s="..|..|pH" id="303" />
-        <Map s="pH" id="304" />
-        <Map s="S1|C1|Compound type 1" id="305" />
-        <Map s="CT1" id="306" />
-        <Map s="S1|C1|pKa value 1" id="307" />
-        <Map s="pKa_1" id="308" />
-        <Map s="S1|C1|Compound type 0" id="309" />
-        <Map s="CT0" id="310" />
-        <Map s="S1|C1|pKa value 0" id="311" />
-        <Map s="pKa_0" id="312" />
-        <Map s="..|pKa_pH_WS_lum_K1" id="313" />
-        <Map s="K1" id="314" />
-        <Map s="..|pKa_pH_WS_lum_K2" id="315" />
-        <Map s="K2" id="316" />
-        <Map s="..|pKa_pH_WS_lum_K3" id="317" />
-        <Map s="K3" id="318" />
-        <Map s="..|pKa_pH_WS_lum_K4" id="319" />
-        <Map s="K4" id="320" />
-        <Map s="..|pKa_pH_WS_lum_K5" id="321" />
-        <Map s="K5" id="322" />
-        <Map s="..|pKa_pH_WS_lum_K6" id="323" />
-        <Map s="K6" id="324" />
-        <Map s="..|pKa_pH_WS_lum_K7" id="325" />
-        <Map s="K7" id="326" />
-        <Map s="..|pKa_pH_WS_lum_K8" id="327" />
-        <Map s="K8" id="328" />
-        <Map s="S1|C1|Solubility gain per charge" id="329" />
-        <Map s="base" id="330" />
-        <Map s="..|Solubility_pKa_pH_Factor" id="331" />
-        <Map s="Solubility_pKa_pH_Factor" id="332" />
-        <Map s="S1|C1|Solubility at reference pH" id="333" />
-        <Map s="Solubility" id="334" />
-        <Map s="Concentration (mass)" id="335" />
-        <Map s="S1|C1|Solubility_pKa_pH_Factor" id="336" />
-        <Map s="Solubility_pKa_REFpH_Factor" id="337" />
-        <Map s="..|..|Liquid" id="338" />
-        <Map s="..|..|..|Height" id="339" />
-        <Map s="..|r1_p0" id="340" />
-        <Map s="r1_p0" id="341" />
-        <Map s="..|r1_p1" id="342" />
-        <Map s="r1_p1" id="343" />
-        <Map s="alpha" id="344" />
-        <Map s="k" id="345" />
-        <Map s="inflow" id="346" />
-        <Map s="..|..|Stomach|Fractional steady state fill level" id="347" />
-        <Map s="alpha_p" id="348" />
-        <Map s="..|..|Stomach|Intestinal transit rate (absolute)" id="349" />
-        <Map s="k_p" id="350" />
-        <Map s="..|..|Stomach|Volume" id="351" />
-        <Map s="V_p" id="352" />
-        <Map s="..|r2_p0" id="353" />
-        <Map s="r2_p0" id="354" />
-        <Map s="..|r2_p1" id="355" />
-        <Map s="r2_p1" id="356" />
-        <Map s="..|Intestinal transit rate" id="357" />
-        <Map s="LuminalVelocity" id="358" />
-        <Map s="S1|Organism|SmallIntestine|Small intestinal transit time factor" id="359" />
-        <Map s="SITT_fact" id="360" />
-        <Map s="..|L_p0" id="361" />
-        <Map s="L_p0" id="362" />
-        <Map s="..|L_p1" id="363" />
-        <Map s="L_p1" id="364" />
-        <Map s="..|..|UpperJejunum|FillLevelFlag" id="365" />
-        <Map s="..|Thickness_p1" id="366" />
-        <Map s="Thickness_p1" id="367" />
-        <Map s="..|Thickness_p2" id="368" />
-        <Map s="Thickness_p2" id="369" />
-        <Map s="..|Thickness_p3" id="370" />
-        <Map s="Thickness_p3" id="371" />
-        <Map s="Inversed length" id="372" />
-        <Map s="V_Intestine" id="373" />
-        <Map s="..|Absorption of liquid" id="374" />
-        <Map s="Outflow" id="375" />
-        <Map s="LT_duo" id="376" />
-        <Map s="..|..|Stomach|Liquid transfer rate" id="377" />
-        <Map s="S1|Neighborhoods|Lumen_duo_Duodenum_pls|C1|Sum of active process rates" id="378" />
-        <Map s="ActiveRates_para" id="379" />
-        <Map s="Amount per time" id="380" />
-        <Map s="S1|Neighborhoods|Lumen_duo_Duodenum_cell|C1|Sum of active process rates" id="381" />
-        <Map s="ActiveRates_trans" id="382" />
-        <Map s="S1|Neighborhoods|Lumen_duo_Duodenum_pls|C1|Sum of passive process rates" id="383" />
-        <Map s="PassiveRates_para" id="384" />
-        <Map s="S1|Neighborhoods|Lumen_duo_Duodenum_cell|C1|Sum of passive process rates" id="385" />
-        <Map s="PassiveRates_trans" id="386" />
-        <Map s="..|Oral mass absorbed segment" id="387" />
-        <Map s="MassAbsorbed" id="388" />
-        <Map s="OralDrugMass" id="389" />
-        <Map s="..|..|LowerJejunum|FillLevelFlag" id="390" />
-        <Map s="LT_uje" id="391" />
-        <Map s="..|..|Duodenum|Liquid transfer rate" id="392" />
-        <Map s="..|..|Duodenum|Fractional steady state fill level" id="393" />
-        <Map s="..|..|Duodenum|Intestinal transit rate (absolute)" id="394" />
-        <Map s="..|..|Duodenum|Volume" id="395" />
-        <Map s="S1|Neighborhoods|Lumen_uje_UpperJejunum_pls|C1|Sum of active process rates" id="396" />
-        <Map s="S1|Neighborhoods|Lumen_uje_UpperJejunum_cell|C1|Sum of active process rates" id="397" />
-        <Map s="S1|Neighborhoods|Lumen_uje_UpperJejunum_pls|C1|Sum of passive process rates" id="398" />
-        <Map s="S1|Neighborhoods|Lumen_uje_UpperJejunum_cell|C1|Sum of passive process rates" id="399" />
-        <Map s="..|..|UpperJejunum|Fractional steady state fill level" id="400" />
-        <Map s="..|..|UpperJejunum|Intestinal transit rate (absolute)" id="401" />
-        <Map s="..|..|UpperJejunum|Volume" id="402" />
-        <Map s="LT_lje" id="403" />
-        <Map s="..|..|UpperJejunum|Liquid transfer rate" id="404" />
-        <Map s="..|..|UpperIleum|FillLevelFlag" id="405" />
-        <Map s="S1|Neighborhoods|Lumen_lje_LowerJejunum_pls|C1|Sum of active process rates" id="406" />
-        <Map s="S1|Neighborhoods|Lumen_lje_LowerJejunum_cell|C1|Sum of active process rates" id="407" />
-        <Map s="S1|Neighborhoods|Lumen_lje_LowerJejunum_pls|C1|Sum of passive process rates" id="408" />
-        <Map s="S1|Neighborhoods|Lumen_lje_LowerJejunum_cell|C1|Sum of passive process rates" id="409" />
-        <Map s="..|..|LowerJejunum|Fractional steady state fill level" id="410" />
-        <Map s="..|..|LowerJejunum|Intestinal transit rate (absolute)" id="411" />
-        <Map s="..|..|LowerJejunum|Volume" id="412" />
-        <Map s="LT_uil" id="413" />
-        <Map s="..|..|LowerJejunum|Liquid transfer rate" id="414" />
-        <Map s="..|..|LowerIleum|FillLevelFlag" id="415" />
-        <Map s="S1|Neighborhoods|Lumen_uil_UpperIleum_pls|C1|Sum of active process rates" id="416" />
-        <Map s="S1|Neighborhoods|Lumen_uil_UpperIleum_cell|C1|Sum of active process rates" id="417" />
-        <Map s="S1|Neighborhoods|Lumen_uil_UpperIleum_pls|C1|Sum of passive process rates" id="418" />
-        <Map s="S1|Neighborhoods|Lumen_uil_UpperIleum_cell|C1|Sum of passive process rates" id="419" />
-        <Map s="..|..|UpperIleum|Fractional steady state fill level" id="420" />
-        <Map s="..|..|UpperIleum|Intestinal transit rate (absolute)" id="421" />
-        <Map s="..|..|UpperIleum|Volume" id="422" />
-        <Map s="LT_lil" id="423" />
-        <Map s="..|..|UpperIleum|Liquid transfer rate" id="424" />
-        <Map s="..|..|Caecum|FillLevelFlag" id="425" />
-        <Map s="S1|Neighborhoods|Lumen_lil_LowerIleum_pls|C1|Sum of active process rates" id="426" />
-        <Map s="S1|Neighborhoods|Lumen_lil_LowerIleum_cell|C1|Sum of active process rates" id="427" />
-        <Map s="S1|Neighborhoods|Lumen_lil_LowerIleum_pls|C1|Sum of passive process rates" id="428" />
-        <Map s="S1|Neighborhoods|Lumen_lil_LowerIleum_cell|C1|Sum of passive process rates" id="429" />
-        <Map s="..|..|LowerIleum|Fractional steady state fill level" id="430" />
-        <Map s="..|..|LowerIleum|Intestinal transit rate (absolute)" id="431" />
-        <Map s="..|..|LowerIleum|Volume" id="432" />
-        <Map s="S1|Organism|LargeIntestine|Large intestinal transit time factor" id="433" />
-        <Map s="LITT_fact" id="434" />
-        <Map s="LT_cae" id="435" />
-        <Map s="..|..|LowerIleum|Liquid transfer rate" id="436" />
-        <Map s="..|..|ColonAscendens|FillLevelFlag" id="437" />
-        <Map s="S1|Neighborhoods|Lumen_cae_Caecum_pls|C1|Sum of active process rates" id="438" />
-        <Map s="S1|Neighborhoods|Lumen_cae_Caecum_cell|C1|Sum of active process rates" id="439" />
-        <Map s="S1|Neighborhoods|Lumen_cae_Caecum_pls|C1|Sum of passive process rates" id="440" />
-        <Map s="S1|Neighborhoods|Lumen_cae_Caecum_cell|C1|Sum of passive process rates" id="441" />
-        <Map s="..|..|Caecum|Fractional steady state fill level" id="442" />
-        <Map s="..|..|Caecum|Intestinal transit rate (absolute)" id="443" />
-        <Map s="..|..|Caecum|Volume" id="444" />
-        <Map s="LT_colasc" id="445" />
-        <Map s="..|..|Caecum|Liquid transfer rate" id="446" />
-        <Map s="..|..|ColonTransversum|FillLevelFlag" id="447" />
-        <Map s="S1|Neighborhoods|Lumen_colasc_ColonAscendens_pls|C1|Sum of active process rates" id="448" />
-        <Map s="S1|Neighborhoods|Lumen_colasc_ColonAscendens_cell|C1|Sum of active process rates" id="449" />
-        <Map s="S1|Neighborhoods|Lumen_colasc_ColonAscendens_pls|C1|Sum of passive process rates" id="450" />
-        <Map s="S1|Neighborhoods|Lumen_colasc_ColonAscendens_cell|C1|Sum of passive process rates" id="451" />
-        <Map s="..|..|ColonDescendens|FillLevelFlag" id="452" />
-        <Map s="LT_coltrans" id="453" />
-        <Map s="..|..|ColonAscendens|Liquid transfer rate" id="454" />
-        <Map s="..|..|ColonAscendens|Fractional steady state fill level" id="455" />
-        <Map s="..|..|ColonAscendens|Intestinal transit rate (absolute)" id="456" />
-        <Map s="..|..|ColonAscendens|Volume" id="457" />
-        <Map s="S1|Neighborhoods|Lumen_coltrans_ColonTransversum_pls|C1|Sum of active process rates" id="458" />
-        <Map s="S1|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|C1|Sum of active process rates" id="459" />
-        <Map s="S1|Neighborhoods|Lumen_coltrans_ColonTransversum_pls|C1|Sum of passive process rates" id="460" />
-        <Map s="S1|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|C1|Sum of passive process rates" id="461" />
-        <Map s="LT_coldesc" id="462" />
-        <Map s="..|..|ColonTransversum|Liquid transfer rate" id="463" />
-        <Map s="..|..|ColonSigmoid|FillLevelFlag" id="464" />
-        <Map s="..|..|ColonTransversum|Fractional steady state fill level" id="465" />
-        <Map s="..|..|ColonTransversum|Intestinal transit rate (absolute)" id="466" />
-        <Map s="..|..|ColonTransversum|Volume" id="467" />
-        <Map s="S1|Neighborhoods|Lumen_coldesc_ColonDescendens_pls|C1|Sum of active process rates" id="468" />
-        <Map s="S1|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|C1|Sum of active process rates" id="469" />
-        <Map s="S1|Neighborhoods|Lumen_coldesc_ColonDescendens_pls|C1|Sum of passive process rates" id="470" />
-        <Map s="S1|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|C1|Sum of passive process rates" id="471" />
-        <Map s="..|..|ColonDescendens|Fractional steady state fill level" id="472" />
-        <Map s="..|..|ColonDescendens|Intestinal transit rate (absolute)" id="473" />
-        <Map s="..|..|ColonDescendens|Volume" id="474" />
-        <Map s="LT_colsigm" id="475" />
-        <Map s="..|..|ColonDescendens|Liquid transfer rate" id="476" />
-        <Map s="..|..|Rectum|FillLevelFlag" id="477" />
-        <Map s="S1|Neighborhoods|Lumen_colsigm_ColonSigmoid_pls|C1|Sum of active process rates" id="478" />
-        <Map s="S1|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|C1|Sum of active process rates" id="479" />
-        <Map s="S1|Neighborhoods|Lumen_colsigm_ColonSigmoid_pls|C1|Sum of passive process rates" id="480" />
-        <Map s="S1|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|C1|Sum of passive process rates" id="481" />
-        <Map s="..|..|ColonSigmoid|Fractional steady state fill level" id="482" />
-        <Map s="..|..|ColonSigmoid|Intestinal transit rate (absolute)" id="483" />
-        <Map s="..|..|ColonSigmoid|Volume" id="484" />
-        <Map s="LT_rect" id="485" />
-        <Map s="..|..|ColonSigmoid|Liquid transfer rate" id="486" />
-        <Map s="S1|Neighborhoods|Lumen_rect_Rectum_pls|C1|Sum of active process rates" id="487" />
-        <Map s="S1|Neighborhoods|Lumen_rect_Rectum_cell|C1|Sum of active process rates" id="488" />
-        <Map s="S1|Neighborhoods|Lumen_rect_Rectum_pls|C1|Sum of passive process rates" id="489" />
-        <Map s="S1|Neighborhoods|Lumen_rect_Rectum_cell|C1|Sum of passive process rates" id="490" />
-        <Map s="M_cae" id="491" />
-        <Map s="M_colasc" id="492" />
-        <Map s="M_coldesc" id="493" />
-        <Map s="M_colsigm" id="494" />
-        <Map s="M_coltrans" id="495" />
-        <Map s="M_duo" id="496" />
-        <Map s="S1|Organism|Lumen|Feces|C1" id="497" />
-        <Map s="M_fec" id="498" />
-        <Map s="M_lil" id="499" />
-        <Map s="M_lje" id="500" />
-        <Map s="M_rect" id="501" />
-        <Map s="M_uil" id="502" />
-        <Map s="M_uje" id="503" />
-        <Map s="S1|Neighborhoods|Lumen_sto_Lumen_duo|C1|Oral mass absorbed" id="504" />
-        <Map s="Mabs_Mucosa" id="505" />
-        <Map s="TotalOralDrugMass" id="506" />
-        <Map s="..|..|Rectum|Liquid transfer rate" id="507" />
-        <Map s="LT_rec" id="508" />
-        <Map s="S1|Neighborhoods|Stomach_pls_Stomach_int|Surface area (plasma/interstitial)" id="509" />
-        <Map s="S1|Neighborhoods|Stomach_int_Stomach_cell|C1|Partition coefficient (interstitial/water)" id="510" />
-        <Map s="S1|Neighborhoods|Stomach_int_Stomach_cell|C1|Partition coefficient (intracellular/water)" id="511" />
-        <Map s="..|Small intestinal transit time" id="512" />
-        <Map s="SITT" id="513" />
-        <Map s="..|Small intestinal transit time factor intercept" id="514" />
-        <Map s="P2" id="515" />
-        <Map s="..|Small intestinal transit time factor slope" id="516" />
-        <Map s="P1" id="517" />
-        <Map s="..|Lymph flow rate (incl. mucosa)" id="518" />
-        <Map s="Q_lymph_incl_Mucosa" id="519" />
-        <Map s="..|Mucosa|Duodenum|Lymph flow rate" id="520" />
-        <Map s="Q_lymph_duo" id="521" />
-        <Map s="..|Mucosa|LowerIleum|Lymph flow rate" id="522" />
-        <Map s="Q_lymph_lil" id="523" />
-        <Map s="..|Mucosa|LowerJejunum|Lymph flow rate" id="524" />
-        <Map s="Q_lymph_lje" id="525" />
-        <Map s="..|Mucosa|UpperIleum|Lymph flow rate" id="526" />
-        <Map s="Q_lymph_uil" id="527" />
-        <Map s="..|Mucosa|UpperJejunum|Lymph flow rate" id="528" />
-        <Map s="Q_lymph_uje" id="529" />
-        <Map s="S1|Neighborhoods|SmallIntestine_pls_SmallIntestine_int|Surface area (plasma/interstitial)" id="530" />
-        <Map s="..|Fluid recirculation flow rate (incl. mucosa)" id="531" />
-        <Map s="J_iso_incl_Mucosa" id="532" />
-        <Map s="..|Mucosa|Duodenum|Fluid recirculation flow rate" id="533" />
-        <Map s="J_iso_duo" id="534" />
-        <Map s="..|Mucosa|LowerIleum|Fluid recirculation flow rate" id="535" />
-        <Map s="J_iso_lil" id="536" />
-        <Map s="..|Mucosa|LowerJejunum|Fluid recirculation flow rate" id="537" />
-        <Map s="J_iso_lje" id="538" />
-        <Map s="..|Mucosa|UpperIleum|Fluid recirculation flow rate" id="539" />
-        <Map s="J_iso_uil" id="540" />
-        <Map s="..|Mucosa|UpperJejunum|Fluid recirculation flow rate" id="541" />
-        <Map s="J_iso_uje" id="542" />
-        <Map s="..|Mucosa|Duodenum|Volume" id="543" />
-        <Map s="V_duo" id="544" />
-        <Map s="..|Mucosa|LowerIleum|Volume" id="545" />
-        <Map s="V_lil" id="546" />
-        <Map s="..|Mucosa|LowerJejunum|Volume" id="547" />
-        <Map s="V_lje" id="548" />
-        <Map s="..|Mucosa|UpperIleum|Volume" id="549" />
-        <Map s="V_uil" id="550" />
-        <Map s="..|Mucosa|UpperJejunum|Volume" id="551" />
-        <Map s="V_uje" id="552" />
-        <Map s="..|..|Volume (mucosa)" id="553" />
-        <Map s="V_Mucosa" id="554" />
-        <Map s="S1|Neighborhoods|SmallIntestine_int_SmallIntestine_cell|C1|Partition coefficient (interstitial/water)" id="555" />
-        <Map s="S1|Neighborhoods|SmallIntestine_int_SmallIntestine_cell|C1|Partition coefficient (intracellular/water)" id="556" />
-        <Map s="..|Fraction mucosa" id="557" />
-        <Map s="fractionMucosa" id="558" />
-        <Map s="..|..|..|..|Lumen|Duodenum|Volume (gut wall)" id="559" />
-        <Map s="V_GutWall" id="560" />
-        <Map s="S1|Neighborhoods|Duodenum_pls_Duodenum_int|Surface area (plasma/interstitial)" id="561" />
-        <Map s="..|..|..|Lymph flow rate (incl. mucosa)" id="562" />
-        <Map s="Q_lymph_intestine" id="563" />
-        <Map s="..|..|..|Volume" id="564" />
-        <Map s="V_intestine" id="565" />
-        <Map s="V_seg" id="566" />
-        <Map s="..|..|..|Fluid recirculation flow rate (incl. mucosa)" id="567" />
-        <Map s="J_iso_intestine" id="568" />
-        <Map s="..|..|..|Blood flow rate" id="569" />
-        <Map s="Q" id="570" />
-        <Map s="..|Fraction of regional blood flow rate" id="571" />
-        <Map s="regionalFractQ" id="572" />
-        <Map s="..|..|..|Mucosa blood flow fraction" id="573" />
-        <Map s="fractQ" id="574" />
-        <Map s="S1|Neighborhoods|Duodenum_int_Duodenum_cell|C1|Partition coefficient (interstitial/water)" id="575" />
-        <Map s="S1|Neighborhoods|Duodenum_int_Duodenum_cell|C1|Partition coefficient (intracellular/water)" id="576" />
-        <Map s="..|..|..|..|Lumen|UpperJejunum|Volume (gut wall)" id="577" />
-        <Map s="S1|Neighborhoods|UpperJejunum_pls_UpperJejunum_int|Surface area (plasma/interstitial)" id="578" />
-        <Map s="S1|Neighborhoods|UpperJejunum_int_UpperJejunum_cell|C1|Partition coefficient (interstitial/water)" id="579" />
-        <Map s="S1|Neighborhoods|UpperJejunum_int_UpperJejunum_cell|C1|Partition coefficient (intracellular/water)" id="580" />
-        <Map s="..|..|..|..|Lumen|LowerJejunum|Volume (gut wall)" id="581" />
-        <Map s="S1|Neighborhoods|LowerJejunum_pls_LowerJejunum_int|Surface area (plasma/interstitial)" id="582" />
-        <Map s="S1|Neighborhoods|LowerJejunum_int_LowerJejunum_cell|C1|Partition coefficient (interstitial/water)" id="583" />
-        <Map s="S1|Neighborhoods|LowerJejunum_int_LowerJejunum_cell|C1|Partition coefficient (intracellular/water)" id="584" />
-        <Map s="..|..|..|..|Lumen|UpperIleum|Volume (gut wall)" id="585" />
-        <Map s="S1|Neighborhoods|UpperIleum_pls_UpperIleum_int|Surface area (plasma/interstitial)" id="586" />
-        <Map s="S1|Neighborhoods|UpperIleum_int_UpperIleum_cell|C1|Partition coefficient (interstitial/water)" id="587" />
-        <Map s="S1|Neighborhoods|UpperIleum_int_UpperIleum_cell|C1|Partition coefficient (intracellular/water)" id="588" />
-        <Map s="..|..|..|..|Lumen|LowerIleum|Volume (gut wall)" id="589" />
-        <Map s="S1|Neighborhoods|LowerIleum_pls_LowerIleum_int|Surface area (plasma/interstitial)" id="590" />
-        <Map s="S1|Neighborhoods|LowerIleum_int_LowerIleum_cell|C1|Partition coefficient (interstitial/water)" id="591" />
-        <Map s="S1|Neighborhoods|LowerIleum_int_LowerIleum_cell|C1|Partition coefficient (intracellular/water)" id="592" />
-        <Map s="S1|Organism|SmallIntestine|Interstitial|Volume" id="593" />
-        <Map s="V_int" id="594" />
-        <Map s="S1|Organism|SmallIntestine|Mucosa|Duodenum|Interstitial|Volume" id="595" />
-        <Map s="V_int_duo" id="596" />
-        <Map s="S1|Organism|SmallIntestine|Mucosa|LowerIleum|Interstitial|Volume" id="597" />
-        <Map s="V_int_lil" id="598" />
-        <Map s="S1|Organism|SmallIntestine|Mucosa|LowerJejunum|Interstitial|Volume" id="599" />
-        <Map s="V_int_lje" id="600" />
-        <Map s="S1|Organism|SmallIntestine|Mucosa|UpperIleum|Interstitial|Volume" id="601" />
-        <Map s="V_int_uil" id="602" />
-        <Map s="S1|Organism|SmallIntestine|Mucosa|UpperJejunum|Interstitial|Volume" id="603" />
-        <Map s="V_int_uje" id="604" />
-        <Map s="S1|Organism|SmallIntestine|Intracellular|Volume" id="605" />
-        <Map s="V_cell" id="606" />
-        <Map s="S1|Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|Volume" id="607" />
-        <Map s="V_cell_duo" id="608" />
-        <Map s="S1|Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|Volume" id="609" />
-        <Map s="V_cell_lil" id="610" />
-        <Map s="S1|Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|Volume" id="611" />
-        <Map s="V_cell_lje" id="612" />
-        <Map s="S1|Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|Volume" id="613" />
-        <Map s="V_cell_uil" id="614" />
-        <Map s="S1|Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|Volume" id="615" />
-        <Map s="V_cell_uje" id="616" />
-        <Map s="S1|Organism|SmallIntestine|Intracellular|C1" id="617" />
-        <Map s="M_cell" id="618" />
-        <Map s="S1|Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|C1" id="619" />
-        <Map s="M_cell_duo" id="620" />
-        <Map s="S1|Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|C1" id="621" />
-        <Map s="M_cell_lil" id="622" />
-        <Map s="S1|Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|C1" id="623" />
-        <Map s="M_cell_lje" id="624" />
-        <Map s="S1|Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|C1" id="625" />
-        <Map s="M_cell_uil" id="626" />
-        <Map s="S1|Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|C1" id="627" />
-        <Map s="M_cell_uje" id="628" />
-        <Map s="S1|Organism|SmallIntestine|Interstitial|C1" id="629" />
-        <Map s="M_int" id="630" />
-        <Map s="S1|Organism|SmallIntestine|Mucosa|Duodenum|Interstitial|C1" id="631" />
-        <Map s="M_int_duo" id="632" />
-        <Map s="S1|Organism|SmallIntestine|Mucosa|LowerIleum|Interstitial|C1" id="633" />
-        <Map s="M_int_lil" id="634" />
-        <Map s="S1|Organism|SmallIntestine|Mucosa|LowerJejunum|Interstitial|C1" id="635" />
-        <Map s="M_int_lje" id="636" />
-        <Map s="S1|Organism|SmallIntestine|Mucosa|UpperIleum|Interstitial|C1" id="637" />
-        <Map s="M_int_uil" id="638" />
-        <Map s="S1|Organism|SmallIntestine|Mucosa|UpperJejunum|Interstitial|C1" id="639" />
-        <Map s="M_int_uje" id="640" />
-        <Map s="..|Mucosa|Caecum|Volume" id="641" />
-        <Map s="V_cae" id="642" />
-        <Map s="..|Mucosa|ColonAscendens|Volume" id="643" />
-        <Map s="V_ca" id="644" />
-        <Map s="..|Mucosa|ColonDescendens|Volume" id="645" />
-        <Map s="V_cd" id="646" />
-        <Map s="..|Mucosa|ColonSigmoid|Volume" id="647" />
-        <Map s="V_cs" id="648" />
-        <Map s="..|Mucosa|ColonTransversum|Volume" id="649" />
-        <Map s="V_ct" id="650" />
-        <Map s="..|Mucosa|Rectum|Volume" id="651" />
-        <Map s="V_rec" id="652" />
-        <Map s="..|Large intestinal transit time" id="653" />
-        <Map s="LITT" id="654" />
-        <Map s="..|Large intestinal transit time factor intercept" id="655" />
-        <Map s="..|Large intestinal transit time factor slope" id="656" />
-        <Map s="..|Mucosa|Caecum|Fluid recirculation flow rate" id="657" />
-        <Map s="J_iso_cae" id="658" />
-        <Map s="..|Mucosa|ColonAscendens|Fluid recirculation flow rate" id="659" />
-        <Map s="J_iso_colasc" id="660" />
-        <Map s="..|Mucosa|ColonDescendens|Fluid recirculation flow rate" id="661" />
-        <Map s="J_iso_coldesc" id="662" />
-        <Map s="..|Mucosa|ColonSigmoid|Fluid recirculation flow rate" id="663" />
-        <Map s="J_iso_colsigm" id="664" />
-        <Map s="..|Mucosa|ColonTransversum|Fluid recirculation flow rate" id="665" />
-        <Map s="J_iso_coltrans" id="666" />
-        <Map s="..|Mucosa|Rectum|Fluid recirculation flow rate" id="667" />
-        <Map s="J_iso_rect" id="668" />
-        <Map s="..|Mucosa|Caecum|Lymph flow rate" id="669" />
-        <Map s="Q_lymph_cae" id="670" />
-        <Map s="..|Mucosa|ColonAscendens|Lymph flow rate" id="671" />
-        <Map s="Q_lymph_colasc" id="672" />
-        <Map s="..|Mucosa|ColonDescendens|Lymph flow rate" id="673" />
-        <Map s="Q_lymph_coldesc" id="674" />
-        <Map s="..|Mucosa|ColonSigmoid|Lymph flow rate" id="675" />
-        <Map s="Q_lymph_colsigm" id="676" />
-        <Map s="..|Mucosa|ColonTransversum|Lymph flow rate" id="677" />
-        <Map s="Q_lymph_coltrans" id="678" />
-        <Map s="..|Mucosa|Rectum|Lymph flow rate" id="679" />
-        <Map s="Q_lymph_rect" id="680" />
-        <Map s="S1|Neighborhoods|LargeIntestine_pls_LargeIntestine_int|Surface area (plasma/interstitial)" id="681" />
-        <Map s="S1|Neighborhoods|LargeIntestine_int_LargeIntestine_cell|C1|Partition coefficient (interstitial/water)" id="682" />
-        <Map s="S1|Neighborhoods|LargeIntestine_int_LargeIntestine_cell|C1|Partition coefficient (intracellular/water)" id="683" />
-        <Map s="..|..|..|..|Lumen|Caecum|Volume (gut wall)" id="684" />
-        <Map s="S1|Neighborhoods|Caecum_pls_Caecum_int|Surface area (plasma/interstitial)" id="685" />
-        <Map s="S1|Neighborhoods|Caecum_int_Caecum_cell|C1|Partition coefficient (interstitial/water)" id="686" />
-        <Map s="S1|Neighborhoods|Caecum_int_Caecum_cell|C1|Partition coefficient (intracellular/water)" id="687" />
-        <Map s="..|..|..|..|Lumen|ColonAscendens|Volume (gut wall)" id="688" />
-        <Map s="S1|Neighborhoods|ColonAscendens_pls_ColonAscendens_int|Surface area (plasma/interstitial)" id="689" />
-        <Map s="S1|Neighborhoods|ColonAscendens_int_ColonAscendens_cell|C1|Partition coefficient (interstitial/water)" id="690" />
-        <Map s="S1|Neighborhoods|ColonAscendens_int_ColonAscendens_cell|C1|Partition coefficient (intracellular/water)" id="691" />
-        <Map s="..|..|..|..|Lumen|ColonTransversum|Volume (gut wall)" id="692" />
-        <Map s="S1|Neighborhoods|ColonTransversum_pls_ColonTransversum_int|Surface area (plasma/interstitial)" id="693" />
-        <Map s="S1|Neighborhoods|ColonTransversum_int_ColonTransversum_cell|C1|Partition coefficient (interstitial/water)" id="694" />
-        <Map s="S1|Neighborhoods|ColonTransversum_int_ColonTransversum_cell|C1|Partition coefficient (intracellular/water)" id="695" />
-        <Map s="..|..|..|..|Lumen|ColonDescendens|Volume (gut wall)" id="696" />
-        <Map s="S1|Neighborhoods|ColonDescendens_pls_ColonDescendens_int|Surface area (plasma/interstitial)" id="697" />
-        <Map s="S1|Neighborhoods|ColonDescendens_int_ColonDescendens_cell|C1|Partition coefficient (interstitial/water)" id="698" />
-        <Map s="S1|Neighborhoods|ColonDescendens_int_ColonDescendens_cell|C1|Partition coefficient (intracellular/water)" id="699" />
-        <Map s="..|..|..|..|Lumen|ColonSigmoid|Volume (gut wall)" id="700" />
-        <Map s="S1|Neighborhoods|ColonSigmoid_pls_ColonSigmoid_int|Surface area (plasma/interstitial)" id="701" />
-        <Map s="S1|Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|C1|Partition coefficient (interstitial/water)" id="702" />
-        <Map s="S1|Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|C1|Partition coefficient (intracellular/water)" id="703" />
-        <Map s="..|..|..|..|Lumen|Rectum|Volume (gut wall)" id="704" />
-        <Map s="S1|Neighborhoods|Rectum_pls_Rectum_int|Surface area (plasma/interstitial)" id="705" />
-        <Map s="S1|Neighborhoods|Rectum_int_Rectum_cell|C1|Partition coefficient (interstitial/water)" id="706" />
-        <Map s="S1|Neighborhoods|Rectum_int_Rectum_cell|C1|Partition coefficient (intracellular/water)" id="707" />
-        <Map s="S1|Organism|LargeIntestine|Interstitial|Volume" id="708" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|Caecum|Interstitial|Volume" id="709" />
-        <Map s="V_int_cae" id="710" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|ColonAscendens|Interstitial|Volume" id="711" />
-        <Map s="V_int_colasc" id="712" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|ColonDescendens|Interstitial|Volume" id="713" />
-        <Map s="V_int_coldesc" id="714" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|ColonSigmoid|Interstitial|Volume" id="715" />
-        <Map s="V_int_colsigm" id="716" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|ColonTransversum|Interstitial|Volume" id="717" />
-        <Map s="V_int_coltrans" id="718" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|Rectum|Interstitial|Volume" id="719" />
-        <Map s="V_int_rect" id="720" />
-        <Map s="S1|Organism|LargeIntestine|Intracellular|Volume" id="721" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|Caecum|Intracellular|Volume" id="722" />
-        <Map s="V_cell_cae" id="723" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|Volume" id="724" />
-        <Map s="V_cell_colasc" id="725" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|Volume" id="726" />
-        <Map s="V_cell_coldesc" id="727" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|Volume" id="728" />
-        <Map s="V_cell_colsigm" id="729" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|Volume" id="730" />
-        <Map s="V_cell_coltrans" id="731" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|Rectum|Intracellular|Volume" id="732" />
-        <Map s="V_cell_rect" id="733" />
-        <Map s="S1|Organism|LargeIntestine|Intracellular|C1" id="734" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|Caecum|Intracellular|C1" id="735" />
-        <Map s="M_cell_cae" id="736" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|C1" id="737" />
-        <Map s="M_cell_colasc" id="738" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|C1" id="739" />
-        <Map s="M_cell_coldesc" id="740" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|C1" id="741" />
-        <Map s="M_cell_colsigm" id="742" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|C1" id="743" />
-        <Map s="M_cell_coltrans" id="744" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|Rectum|Intracellular|C1" id="745" />
-        <Map s="M_cell_rect" id="746" />
-        <Map s="S1|Organism|LargeIntestine|Interstitial|C1" id="747" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|Caecum|Interstitial|C1" id="748" />
-        <Map s="M_int_cae" id="749" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|ColonAscendens|Interstitial|C1" id="750" />
-        <Map s="M_int_colasc" id="751" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|ColonDescendens|Interstitial|C1" id="752" />
-        <Map s="M_int_coldesc" id="753" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|ColonSigmoid|Interstitial|C1" id="754" />
-        <Map s="M_int_colsigm" id="755" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|ColonTransversum|Interstitial|C1" id="756" />
-        <Map s="M_int_coltrans" id="757" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|Rectum|Interstitial|C1" id="758" />
-        <Map s="M_int_rect" id="759" />
-        <Map s="S1|Neighborhoods|Liver_pls_Liver_int|Surface area (plasma/interstitial)" id="760" />
-        <Map s="S1|Neighborhoods|Liver_int_Liver_cell|C1|Partition coefficient (interstitial/water)" id="761" />
-        <Map s="S1|Neighborhoods|Liver_int_Liver_cell|C1|Partition coefficient (intracellular/water)" id="762" />
-        <Map s="S1|Neighborhoods|Lung_pls_Lung_int|Surface area (plasma/interstitial)" id="763" />
-        <Map s="S1|Organism|Bone|Blood flow rate" id="764" />
-        <Map s="Q_bon" id="765" />
-        <Map s="S1|Organism|Brain|Blood flow rate" id="766" />
-        <Map s="Q_brn" id="767" />
-        <Map s="S1|Organism|Fat|Blood flow rate" id="768" />
-        <Map s="Q_fat" id="769" />
-        <Map s="S1|Organism|Gonads|Blood flow rate" id="770" />
-        <Map s="Q_tes" id="771" />
-        <Map s="S1|Organism|Heart|Blood flow rate" id="772" />
-        <Map s="Q_hrt" id="773" />
-        <Map s="S1|Organism|Kidney|Blood flow rate" id="774" />
-        <Map s="Q_kid" id="775" />
-        <Map s="S1|Organism|LargeIntestine|Blood flow rate" id="776" />
-        <Map s="Q_lin" id="777" />
-        <Map s="S1|Organism|Liver|Blood flow rate" id="778" />
-        <Map s="Q_liv" id="779" />
-        <Map s="S1|Organism|Muscle|Blood flow rate" id="780" />
-        <Map s="Q_mus" id="781" />
-        <Map s="S1|Organism|Pancreas|Blood flow rate" id="782" />
-        <Map s="Q_pan" id="783" />
-        <Map s="S1|Organism|Skin|Blood flow rate" id="784" />
-        <Map s="Q_skn" id="785" />
-        <Map s="S1|Organism|SmallIntestine|Blood flow rate" id="786" />
-        <Map s="Q_sin" id="787" />
-        <Map s="S1|Organism|Spleen|Blood flow rate" id="788" />
-        <Map s="Q_spl" id="789" />
-        <Map s="S1|Organism|Stomach|Blood flow rate" id="790" />
-        <Map s="Q_sto" id="791" />
-        <Map s="S1|Neighborhoods|Lung_int_Lung_cell|C1|Partition coefficient (interstitial/water)" id="792" />
-        <Map s="S1|Neighborhoods|Lung_int_Lung_cell|C1|Partition coefficient (intracellular/water)" id="793" />
-        <Map s="S1|Neighborhoods|Muscle_pls_Muscle_int|Surface area (plasma/interstitial)" id="794" />
-        <Map s="S1|Neighborhoods|Muscle_int_Muscle_cell|C1|Partition coefficient (interstitial/water)" id="795" />
-        <Map s="S1|Neighborhoods|Muscle_int_Muscle_cell|C1|Partition coefficient (intracellular/water)" id="796" />
-        <Map s="S1|Neighborhoods|Pancreas_pls_Pancreas_int|Surface area (plasma/interstitial)" id="797" />
-        <Map s="S1|Neighborhoods|Pancreas_int_Pancreas_cell|C1|Partition coefficient (interstitial/water)" id="798" />
-        <Map s="S1|Neighborhoods|Pancreas_int_Pancreas_cell|C1|Partition coefficient (intracellular/water)" id="799" />
-        <Map s="S1|Organism|LargeIntestine|Lymph flow rate (incl. mucosa)" id="800" />
-        <Map s="Q_Lymph_lin_incl_Mucosa" id="801" />
-        <Map s="S1|Organism|Pancreas|Lymph flow rate" id="802" />
-        <Map s="Q_Lymph_pan" id="803" />
-        <Map s="S1|Organism|SmallIntestine|Lymph flow rate (incl. mucosa)" id="804" />
-        <Map s="Q_Lymph_sin_incl_Mucosa" id="805" />
-        <Map s="S1|Organism|Spleen|Lymph flow rate" id="806" />
-        <Map s="Q_Lymph_spl" id="807" />
-        <Map s="S1|Organism|Stomach|Lymph flow rate" id="808" />
-        <Map s="Q_Lymph_sto" id="809" />
-        <Map s="S1|Neighborhoods|Skin_pls_Skin_int|Surface area (plasma/interstitial)" id="810" />
-        <Map s="S1|Neighborhoods|Skin_int_Skin_cell|C1|Partition coefficient (interstitial/water)" id="811" />
-        <Map s="S1|Neighborhoods|Skin_int_Skin_cell|C1|Partition coefficient (intracellular/water)" id="812" />
-        <Map s="S1|Neighborhoods|Spleen_pls_Spleen_int|Surface area (plasma/interstitial)" id="813" />
-        <Map s="S1|Neighborhoods|Spleen_int_Spleen_cell|C1|Partition coefficient (interstitial/water)" id="814" />
-        <Map s="S1|Neighborhoods|Spleen_int_Spleen_cell|C1|Partition coefficient (intracellular/water)" id="815" />
-        <Map s="S1|Organism|Saliva|Volume" id="816" />
-        <Map s="V_slv" id="817" />
-        <Map s="..|GET_beta (Weibull function)" id="818" />
-        <Map s="Meal_beta" id="819" />
-        <Map s="..|Meal energy content" id="820" />
-        <Map s="Energy" id="821" />
-        <Map s="S1|Organism|Lumen|Stomach|GET_alpha (Weibull function) variability factor" id="822" />
-        <Map s="Variability_Factor" id="823" />
-        <Map s="..|Meal fraction solid" id="824" />
-        <Map s="fraction_solid" id="825" />
-        <Map s="S1|Organism|Lumen|Stomach|GET_beta (Weibull function) variability factor" id="826" />
-        <Map s="..|..|..|Meal volume" id="827" />
-        <Map s="MealVolume" id="828" />
-        <Map s="..|..|..|GET_alpha (Weibull function)" id="829" />
-        <Map s="Meal_alpha" id="830" />
-        <Map s="..|..|..|GET_beta (Weibull function)" id="831" />
-        <Map s="..|..|Start time" id="832" />
-        <Map s="StartTime" id="833" />
-        <Map s="..|..|..|Meal_pH_exponent" id="834" />
-        <Map s="S1|Organism|Lumen|Stomach|pH in fasted state" id="835" />
-        <Map s="S1|Organism|Lumen|Stomach|pH in fed state" id="836" />
-        <Map s="pH_fed" id="837" />
-        <Map s="..|Start time" id="838" />
-        <Map s="S1|Organism|Lumen|Stomach|Gastric emptying time" id="839" />
-        <Map s="StomachIntestinalTransitRate" id="840" />
-        <Map s="S1|Organism|Gallbladder|C1" id="841" />
-        <Map s="S1|Organism|Gallbladder|Gallbladder ejection fraction" id="842" />
-        <Map s="EHC_EjectionFraction" id="843" />
-        <Map s="S1|Organism|Gallbladder|Gallbladder ejection half-time" id="844" />
-        <Map s="EHC_Halftime" id="845" />
-        <Map s="..|..|Gallbladder emptying enabled" id="846" />
-        <Map s="EHC_Enabled" id="847" />
-        <Map s="..|..|Gallbladder emptying lag time" id="848" />
-        <Map s="EHCLagTime" id="849" />
-        <Map s="S1|Organism|Gallbladder|Time to complete gallbladder refilling" id="850" />
-        <Map s="GallbladderRefillTime" id="851" />
-        <Map s="S1|Organism|VenousBlood|BloodCells|C1|Concentration" id="852" />
-        <Map s="S1|Organism|VenousBlood|Plasma|C1|Concentration" id="853" />
-        <Map s="S1|C1|P (blood cells-&gt;plasma)" id="854" />
-        <Map s="P_rbc_pls" id="855" />
-        <Map s="Velocity" id="856" />
-        <Map s="S1|C1|P (plasma-&gt;blood cells)" id="857" />
-        <Map s="P_pls_rbc" id="858" />
-        <Map s="S1|Neighborhoods|VenousBlood_pls_VenousBlood_bc|Surface area (blood cells/plasma)" id="859" />
-        <Map s="SA_bc" id="860" />
-        <Map s="S1|Organism|VenousBlood|Plasma|..|Volume" id="861" />
-        <Map s="S1|Organism|Surface/Volume ratio (blood cells)" id="862" />
-        <Map s="A_to_V_bc" id="863" />
-        <Map s="S1|Organism|Lung|Plasma|..|Blood flow rate" id="864" />
-        <Map s="S1|Organism|Lung|BloodCells|..|Blood flow rate" id="865" />
-        <Map s="S1|Neighborhoods|ArterialBlood_pls_ArterialBlood_bc|Surface area (blood cells/plasma)" id="866" />
-        <Map s="S1|Organism|ArterialBlood|Plasma|..|Volume" id="867" />
-        <Map s="S1|Organism|Bone|Plasma|..|Blood flow rate" id="868" />
-        <Map s="S1|Organism|Bone|BloodCells|..|Blood flow rate" id="869" />
-        <Map s="S1|Organism|Protein ratio (interstial/plasma)" id="870" />
-        <Map s="f_proteins_int_to_pls" id="871" />
-        <Map s="S1|Organism|Vf (water,interstitial)" id="872" />
-        <Map s="f_water_int" id="873" />
-        <Map s="S1|Organism|Vf (water,plasma)" id="874" />
-        <Map s="f_water_pls" id="875" />
-        <Map s="S1|Organism|Bone|Interstitial|C1|Concentration" id="876" />
-        <Map s="S1|Neighborhoods|Bone_pls_Bone_int|C1|P (plasma&lt;-&gt;interstitial)" id="877" />
-        <Map s="P_endothelial" id="878" />
-        <Map s="S1|Neighborhoods|Bone_pls_Bone_int|C1|Partition coefficient (interstitial/plasma)" id="879" />
-        <Map s="K_int_pls" id="880" />
-        <Map s="SA" id="881" />
-        <Map s="S1|Organism|Bone|Plasma|..|Fraction vascular" id="882" />
-        <Map s="f_vas_org" id="883" />
-        <Map s="S1|Organism|Bone|Plasma|..|Volume" id="884" />
-        <Map s="S1|Organism|SA proportionality factor" id="885" />
-        <Map s="S1|Neighborhoods|Bone_pls_Bone_bc|Surface area (blood cells/plasma)" id="886" />
-        <Map s="..|Partition coefficient (intracellular/plasma)" id="887" />
-        <Map s="K_cell_pls" id="888" />
-        <Map s="S1|C1|Lipophilicity" id="889" />
-        <Map s="LogMA" id="890" />
-        <Map s="Log Units" id="891" />
-        <Map s="S1|C1|Partition coefficient (water/protein)" id="892" />
-        <Map s="KProt" id="893" />
-        <Map s="S1|Organism|Bone|Interstitial|..|Vf (lipid)" id="894" />
-        <Map s="f_lipids" id="895" />
-        <Map s="S1|Organism|Bone|Interstitial|..|Vf (protein)" id="896" />
-        <Map s="f_proteins" id="897" />
-        <Map s="S1|Organism|Bone|Interstitial|..|Vf (water)" id="898" />
-        <Map s="f_water" id="899" />
-        <Map s="..|P_int_cell_factor" id="900" />
-        <Map s="P_int_cell_factor" id="901" />
-        <Map s="S1|C1|Permeability" id="902" />
-        <Map s="P" id="903" />
-        <Map s="..|P_cell_int_factor" id="904" />
-        <Map s="P_cell_int_factor" id="905" />
-        <Map s="..|P (interstitial-&gt;intracellular)" id="906" />
-        <Map s="P_int_cell" id="907" />
-        <Map s="..|..|Surface area (interstitial/intracellular)" id="908" />
-        <Map s="..|P (intracellular-&gt;interstitial)" id="909" />
-        <Map s="P_cell_int" id="910" />
-        <Map s="S1|Organism|Bone|Intracellular|C1|Concentration" id="911" />
-        <Map s="S1|Neighborhoods|Bone_int_Bone_cell|C1|P*SA interstitial -&gt; intracellular" id="912" />
-        <Map s="PA_int_cell" id="913" />
-        <Map s="S1|Neighborhoods|Bone_int_Bone_cell|C1|P*SA intracellular -&gt; interstitial" id="914" />
-        <Map s="PA_cell_int" id="915" />
-        <Map s="S1|Organism|Bone|Interstitial|..|Volume" id="916" />
-        <Map s="S1|Organism|Brain|BloodCells|C1|Concentration" id="917" />
-        <Map s="S1|Organism|Brain|Plasma|C1|Concentration" id="918" />
-        <Map s="S1|Neighborhoods|Brain_pls_Brain_bc|Surface area (blood cells/plasma)" id="919" />
-        <Map s="S1|Organism|Brain|Plasma|..|Fraction vascular" id="920" />
-        <Map s="S1|Organism|Brain|Plasma|..|Volume" id="921" />
-        <Map s="S1|Organism|Brain|Interstitial|..|Vf (lipid)" id="922" />
-        <Map s="S1|Organism|Brain|Interstitial|..|Vf (protein)" id="923" />
-        <Map s="S1|Organism|Brain|Interstitial|..|Vf (water)" id="924" />
-        <Map s="S1|Neighborhoods|Brain_pls_Brain_int|C1|Partition coefficient (interstitial/plasma)" id="925" />
-        <Map s="S1|Organism|Brain|Intracellular|C1|Concentration" id="926" />
-        <Map s="S1|Organism|Brain|Interstitial|C1|Concentration" id="927" />
-        <Map s="S1|Neighborhoods|Brain_int_Brain_cell|C1|P*SA interstitial -&gt; intracellular" id="928" />
-        <Map s="S1|Neighborhoods|Brain_int_Brain_cell|C1|P*SA intracellular -&gt; interstitial" id="929" />
-        <Map s="S1|Organism|Brain|Interstitial|..|Volume" id="930" />
-        <Map s="S1|Organism|Brain|Plasma|..|Blood flow rate" id="931" />
-        <Map s="S1|Neighborhoods|Brain_pls_Brain_int|C1|P (plasma&lt;-&gt;interstitial)" id="932" />
-        <Map s="S1|Organism|Brain|BloodCells|..|Blood flow rate" id="933" />
-        <Map s="S1|Organism|Fat|Plasma|..|Blood flow rate" id="934" />
-        <Map s="S1|Neighborhoods|Fat_pls_Fat_bc|Surface area (blood cells/plasma)" id="935" />
-        <Map s="S1|Organism|Fat|Plasma|..|Fraction vascular" id="936" />
-        <Map s="S1|Organism|Fat|Plasma|..|Volume" id="937" />
-        <Map s="S1|Organism|Fat|Interstitial|..|Vf (lipid)" id="938" />
-        <Map s="S1|Organism|Fat|Interstitial|..|Vf (protein)" id="939" />
-        <Map s="S1|Organism|Fat|Interstitial|..|Vf (water)" id="940" />
-        <Map s="S1|Neighborhoods|Fat_pls_Fat_int|C1|Partition coefficient (interstitial/plasma)" id="941" />
-        <Map s="S1|Organism|Fat|Intracellular|C1|Concentration" id="942" />
-        <Map s="S1|Organism|Fat|Interstitial|C1|Concentration" id="943" />
-        <Map s="S1|Neighborhoods|Fat_int_Fat_cell|C1|P*SA interstitial -&gt; intracellular" id="944" />
-        <Map s="S1|Neighborhoods|Fat_int_Fat_cell|C1|P*SA intracellular -&gt; interstitial" id="945" />
-        <Map s="S1|Organism|Fat|Interstitial|..|Volume" id="946" />
-        <Map s="S1|Organism|Fat|BloodCells|..|Blood flow rate" id="947" />
-        <Map s="S1|Neighborhoods|Fat_pls_Fat_int|C1|P (plasma&lt;-&gt;interstitial)" id="948" />
-        <Map s="S1|Organism|Gonads|BloodCells|..|Blood flow rate" id="949" />
-        <Map s="S1|Organism|Gonads|BloodCells|C1|Concentration" id="950" />
-        <Map s="S1|Organism|Gonads|Plasma|..|Blood flow rate" id="951" />
-        <Map s="S1|Organism|Gonads|Plasma|C1|Concentration" id="952" />
-        <Map s="S1|Organism|Gonads|Interstitial|C1|Concentration" id="953" />
-        <Map s="S1|Neighborhoods|Gonads_pls_Gonads_int|C1|P (plasma&lt;-&gt;interstitial)" id="954" />
-        <Map s="S1|Neighborhoods|Gonads_pls_Gonads_int|C1|Partition coefficient (interstitial/plasma)" id="955" />
-        <Map s="S1|Organism|Gonads|Plasma|..|Fraction vascular" id="956" />
-        <Map s="S1|Organism|Gonads|Plasma|..|Volume" id="957" />
-        <Map s="S1|Neighborhoods|Gonads_pls_Gonads_bc|Surface area (blood cells/plasma)" id="958" />
-        <Map s="S1|Organism|Gonads|Interstitial|..|Vf (lipid)" id="959" />
-        <Map s="S1|Organism|Gonads|Interstitial|..|Vf (protein)" id="960" />
-        <Map s="S1|Organism|Gonads|Interstitial|..|Vf (water)" id="961" />
-        <Map s="S1|Organism|Gonads|Intracellular|C1|Concentration" id="962" />
-        <Map s="S1|Neighborhoods|Gonads_int_Gonads_cell|C1|P*SA interstitial -&gt; intracellular" id="963" />
-        <Map s="S1|Neighborhoods|Gonads_int_Gonads_cell|C1|P*SA intracellular -&gt; interstitial" id="964" />
-        <Map s="S1|Organism|Gonads|Interstitial|..|Volume" id="965" />
-        <Map s="S1|Organism|Heart|BloodCells|..|Blood flow rate" id="966" />
-        <Map s="S1|Organism|Heart|BloodCells|C1|Concentration" id="967" />
-        <Map s="S1|Organism|Heart|Interstitial|..|Vf (lipid)" id="968" />
-        <Map s="S1|Organism|Heart|Interstitial|..|Vf (protein)" id="969" />
-        <Map s="S1|Organism|Heart|Interstitial|..|Vf (water)" id="970" />
-        <Map s="S1|Neighborhoods|Heart_pls_Heart_int|C1|Partition coefficient (interstitial/plasma)" id="971" />
-        <Map s="S1|Organism|Heart|Intracellular|C1|Concentration" id="972" />
-        <Map s="S1|Organism|Heart|Interstitial|C1|Concentration" id="973" />
-        <Map s="S1|Neighborhoods|Heart_int_Heart_cell|C1|P*SA interstitial -&gt; intracellular" id="974" />
-        <Map s="S1|Neighborhoods|Heart_int_Heart_cell|C1|P*SA intracellular -&gt; interstitial" id="975" />
-        <Map s="S1|Organism|Heart|Interstitial|..|Volume" id="976" />
-        <Map s="S1|Organism|Heart|Plasma|C1|Concentration" id="977" />
-        <Map s="S1|Neighborhoods|Heart_pls_Heart_bc|Surface area (blood cells/plasma)" id="978" />
-        <Map s="S1|Organism|Heart|Plasma|..|Fraction vascular" id="979" />
-        <Map s="S1|Organism|Heart|Plasma|..|Volume" id="980" />
-        <Map s="S1|Neighborhoods|Heart_pls_Heart_int|C1|P (plasma&lt;-&gt;interstitial)" id="981" />
-        <Map s="S1|Organism|Heart|Plasma|..|Blood flow rate" id="982" />
-        <Map s="S1|Organism|Kidney|BloodCells|..|Blood flow rate" id="983" />
-        <Map s="S1|Organism|Kidney|BloodCells|C1|Concentration" id="984" />
-        <Map s="S1|Organism|Kidney|Interstitial|..|Vf (lipid)" id="985" />
-        <Map s="S1|Organism|Kidney|Interstitial|..|Vf (protein)" id="986" />
-        <Map s="S1|Organism|Kidney|Interstitial|..|Vf (water)" id="987" />
-        <Map s="S1|Neighborhoods|Kidney_pls_Kidney_int|C1|Partition coefficient (interstitial/plasma)" id="988" />
-        <Map s="S1|Organism|Kidney|Intracellular|C1|Concentration" id="989" />
-        <Map s="S1|Organism|Kidney|Interstitial|C1|Concentration" id="990" />
-        <Map s="S1|Neighborhoods|Kidney_int_Kidney_cell|C1|P*SA interstitial -&gt; intracellular" id="991" />
-        <Map s="S1|Neighborhoods|Kidney_int_Kidney_cell|C1|P*SA intracellular -&gt; interstitial" id="992" />
-        <Map s="S1|Organism|Kidney|Interstitial|..|Volume" id="993" />
-        <Map s="S1|Organism|Kidney|Plasma|C1|Concentration" id="994" />
-        <Map s="S1|Neighborhoods|Kidney_pls_Kidney_bc|Surface area (blood cells/plasma)" id="995" />
-        <Map s="S1|Organism|Kidney|Plasma|..|Fraction vascular" id="996" />
-        <Map s="S1|Organism|Kidney|Plasma|..|Volume" id="997" />
-        <Map s="S1|Neighborhoods|Kidney_pls_Kidney_int|C1|P (plasma&lt;-&gt;interstitial)" id="998" />
-        <Map s="S1|Organism|SmallIntestine|Mucosa|UpperJejunum|Plasma|C1|Concentration" id="999" />
-        <Map s="S1|Organism|SmallIntestine|Mucosa|UpperJejunum|Plasma|..|Blood flow rate" id="1000" />
-        <Map s="S1|Neighborhoods|UpperJejunum_pls_PortalVein_pls|C1|Mass transfer rate (mucosa to portal vein plasma)" id="1001" />
-        <Map s="MassTransferMucosaToPvePlasmaRate" id="1002" />
-        <Map s="S1|Neighborhoods|Lumen_uje_UpperJejunum_cell|C1|DrugAbsorption_trans|ProcessRate" id="1003" />
-        <Map s="P_1" id="1004" />
-        <Map s="..|pKa_pH_WS_cell_F1" id="1005" />
-        <Map s="..|pKa_pH_WS_cell_F2" id="1006" />
-        <Map s="..|pKa_pH_WS_cell_F3" id="1007" />
-        <Map s="S1|Organism|Lumen|UpperJejunum|Effective surface area enhancement factor" id="1008" />
-        <Map s="AeffFactor" id="1009" />
-        <Map s="S1|Organism|Lumen|UpperJejunum|Geometric surface area" id="1010" />
-        <Map s="Ageom" id="1011" />
-        <Map s="S1|Organism|Lumen|UpperJejunum|Liquid" id="1012" />
-        <Map s="DrugLiquid" id="1013" />
-        <Map s="S1|Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|C1|Concentration" id="1014" />
-        <Map s="DrugMucosa" id="1015" />
-        <Map s="S1|C1|Intestinal permeability (transcellular)" id="1016" />
-        <Map s="P_int_trans" id="1017" />
-        <Map s="S1|C1|Molecular weight" id="1018" />
-        <Map s="MW" id="1019" />
-        <Map s="Molecular weight" id="1020" />
-        <Map s="S1|Neighborhoods|Lumen_uje_UpperJejunum_cell|C1|P_int_trans_cell_lum_factor" id="1021" />
-        <Map s="P_int_trans_cell_lum_factor" id="1022" />
-        <Map s="S1|Neighborhoods|Lumen_uje_UpperJejunum_cell|C1|P_int_trans_lum_cell_factor" id="1023" />
-        <Map s="P_int_trans_lum_cell_factor" id="1024" />
-        <Map s="S1|Organism|Lumen|UpperJejunum|C1|Solubility" id="1025" />
-        <Map s="S1|Organism|Lumen|UpperJejunum|..|OralApplicationsEnabled" id="1026" />
-        <Map s="S1|Organism|Lumen|UpperJejunum|..|Transcellular absorption sink condition" id="1027" />
-        <Map s="SinkCondition_trans" id="1028" />
-        <Map s="..|pKa_pH_WS_cell_K1" id="1029" />
-        <Map s="..|pKa_pH_WS_cell_K2" id="1030" />
-        <Map s="..|pKa_pH_WS_cell_K3" id="1031" />
-        <Map s="..|pKa_pH_WS_cell_K4" id="1032" />
-        <Map s="..|pKa_pH_WS_cell_K5" id="1033" />
-        <Map s="..|pKa_pH_WS_cell_K6" id="1034" />
-        <Map s="..|pKa_pH_WS_cell_K7" id="1035" />
-        <Map s="..|pKa_pH_WS_cell_K8" id="1036" />
-        <Map s="S1|C1|base_For_Pint_Factor" id="1037" />
-        <Map s="S1|C1|Use pH- and pKa-dependent penalty factor for charged molecule fraction" id="1038" />
-        <Map s="UsePenaltyFactor" id="1039" />
-        <Map s="S1|Neighborhoods|UpperJejunum_int_UpperJejunum_cell|C1|Partition coefficient (intracellular/plasma)" id="1040" />
-        <Map s="S1|Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|pH" id="1041" />
-        <Map s="S1|Organism|Lumen|UpperJejunum|pH" id="1042" />
-        <Map s="S1|Neighborhoods|Lumen_uje_UpperJejunum_cell|C1|Drug absorption rate (lumen to mucosa)" id="1043" />
-        <Map s="DrugAbsorptionLumenToMucosaRate" id="1044" />
-        <Map s="S1|C1|Intestinal permeability (paracellular)" id="1045" />
-        <Map s="P_int_para" id="1046" />
-        <Map s="S1|Organism|Lumen|UpperJejunum|..|Paracellular absorption sink condition" id="1047" />
-        <Map s="SinkCondition_para" id="1048" />
-        <Map s="S1|Neighborhoods|Lumen_uje_UpperJejunum_pls|C1|DrugAbsorption_para|ProcessRate" id="1049" />
-        <Map s="S1|Neighborhoods|Lumen_uje_UpperJejunum_pls|C1|Drug absorption rate (lumen to mucosa)" id="1050" />
-        <Map s="S1|Organism|SmallIntestine|Mucosa|UpperJejunum|BloodCells|C1|Concentration" id="1051" />
-        <Map s="S1|Organism|SmallIntestine|Mucosa|UpperJejunum|BloodCells|..|Blood flow rate" id="1052" />
-        <Map s="S1|Neighborhoods|UpperJejunum_bc_PortalVein_bc|C1|Mass transfer rate (mucosa to portal vein blood cells)" id="1053" />
-        <Map s="MassTransferMucosaToPveBCRate" id="1054" />
-        <Map s="S1|Organism|Kidney|Plasma|..|Blood flow rate" id="1055" />
-        <Map s="S1|Organism|Lumen|UpperIleum|..|OralApplicationsEnabled" id="1056" />
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-        <Map s="S1|Neighborhoods|LargeIntestine_pls_LargeIntestine_int|C1|Partition coefficient (interstitial/plasma)" id="1266" />
-        <Map s="S1|Organism|LargeIntestine|Intracellular|C1|Concentration" id="1267" />
-        <Map s="S1|Organism|LargeIntestine|Interstitial|C1|Concentration" id="1268" />
-        <Map s="S1|Neighborhoods|LargeIntestine_int_LargeIntestine_cell|C1|P*SA interstitial -&gt; intracellular" id="1269" />
-        <Map s="S1|Neighborhoods|LargeIntestine_int_LargeIntestine_cell|C1|P*SA intracellular -&gt; interstitial" id="1270" />
-        <Map s="S1|Organism|LargeIntestine|Interstitial|..|Volume" id="1271" />
-        <Map s="S1|Organism|LargeIntestine|Volume (mucosa)" id="1272" />
-        <Map s="S1|Neighborhoods|LargeIntestine_pls_LargeIntestine_int|C1|P (plasma&lt;-&gt;interstitial)" id="1273" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|Caecum|Plasma|..|Blood flow rate" id="1274" />
-        <Map s="S1|Neighborhoods|LargeIntestine_pls_Caecum_pls|C1|Mass transfer rate (intestine to mucosa plasma)" id="1275" />
-        <Map s="S1|Organism|LargeIntestine|Plasma|..|Blood flow rate" id="1276" />
-        <Map s="S1|Organism|LargeIntestine|Plasma|..|Mucosa blood flow fraction" id="1277" />
-        <Map s="S1|Organism|Liver|BloodCells|C1|Concentration" id="1278" />
-        <Map s="S1|Organism|Liver|Plasma|C1|Concentration" id="1279" />
-        <Map s="S1|Neighborhoods|Liver_pls_Liver_bc|Surface area (blood cells/plasma)" id="1280" />
-        <Map s="S1|Organism|Liver|Plasma|..|Fraction vascular" id="1281" />
-        <Map s="S1|Organism|Liver|Plasma|..|Volume" id="1282" />
-        <Map s="S1|Organism|Liver|Plasma|..|Blood flow rate" id="1283" />
-        <Map s="S1|Organism|Liver|Plasma|..|..|PortalVein|Blood flow rate" id="1284" />
-        <Map s="Q_pve" id="1285" />
-        <Map s="S1|Organism|Liver|Interstitial|..|Vf (lipid)" id="1286" />
-        <Map s="S1|Organism|Liver|Interstitial|..|Vf (protein)" id="1287" />
-        <Map s="S1|Organism|Liver|Interstitial|..|Vf (water)" id="1288" />
-        <Map s="..|P*SA interstitial -&gt; intracellular" id="1289" />
-        <Map s="PA_liv" id="1290" />
-        <Map s="S1|Organism|Liver|Interstitial|..|Blood flow rate" id="1291" />
-        <Map s="S1|Organism|Liver|Interstitial|..|..|PortalVein|Blood flow rate" id="1292" />
-        <Map s="S1|Neighborhoods|Liver_pls_Liver_int|C1|Partition coefficient (interstitial/plasma)" id="1293" />
-        <Map s="S1|Organism|Liver|Intracellular|C1|Concentration" id="1294" />
-        <Map s="S1|Organism|Liver|Interstitial|C1|Concentration" id="1295" />
-        <Map s="S1|Neighborhoods|Liver_int_Liver_cell|C1|P*SA interstitial -&gt; intracellular" id="1296" />
-        <Map s="S1|Neighborhoods|Liver_int_Liver_cell|C1|P*SA intracellular -&gt; interstitial" id="1297" />
-        <Map s="S1|Organism|Liver|Interstitial|..|Volume" id="1298" />
-        <Map s="S1|Neighborhoods|Liver_pls_Liver_int|C1|P (plasma&lt;-&gt;interstitial)" id="1299" />
-        <Map s="GallbladderEmptyingRate" id="1300" />
-        <Map s="S1|Organism|Liver|BloodCells|..|Blood flow rate" id="1301" />
-        <Map s="S1|Organism|Liver|BloodCells|..|..|PortalVein|Blood flow rate" id="1302" />
-        <Map s="S1|Organism|Lung|BloodCells|C1|Concentration" id="1303" />
-        <Map s="S1|Organism|Lung|Plasma|C1|Concentration" id="1304" />
-        <Map s="S1|Neighborhoods|Lung_pls_Lung_bc|Surface area (blood cells/plasma)" id="1305" />
-        <Map s="S1|Organism|Lung|Plasma|..|Fraction vascular" id="1306" />
-        <Map s="S1|Organism|Lung|Plasma|..|Volume" id="1307" />
-        <Map s="S1|Organism|Lung|Interstitial|C1|Concentration" id="1308" />
-        <Map s="S1|Neighborhoods|Lung_pls_Lung_int|C1|P (plasma&lt;-&gt;interstitial)" id="1309" />
-        <Map s="S1|Neighborhoods|Lung_pls_Lung_int|C1|Partition coefficient (interstitial/plasma)" id="1310" />
-        <Map s="S1|Organism|Lung|Interstitial|..|Vf (lipid)" id="1311" />
-        <Map s="S1|Organism|Lung|Interstitial|..|Vf (protein)" id="1312" />
-        <Map s="S1|Organism|Lung|Interstitial|..|Vf (water)" id="1313" />
-        <Map s="S1|Organism|Lung|Intracellular|C1|Concentration" id="1314" />
-        <Map s="S1|Neighborhoods|Lung_int_Lung_cell|C1|P*SA interstitial -&gt; intracellular" id="1315" />
-        <Map s="S1|Neighborhoods|Lung_int_Lung_cell|C1|P*SA intracellular -&gt; interstitial" id="1316" />
-        <Map s="S1|Organism|Lung|Interstitial|..|Volume" id="1317" />
-        <Map s="S1|Organism|Muscle|Interstitial|..|Vf (lipid)" id="1318" />
-        <Map s="S1|Organism|Muscle|Interstitial|..|Vf (protein)" id="1319" />
-        <Map s="S1|Organism|Muscle|Interstitial|..|Vf (water)" id="1320" />
-        <Map s="S1|Neighborhoods|Muscle_pls_Muscle_int|C1|Partition coefficient (interstitial/plasma)" id="1321" />
-        <Map s="S1|Organism|Muscle|Intracellular|C1|Concentration" id="1322" />
-        <Map s="S1|Organism|Muscle|Interstitial|C1|Concentration" id="1323" />
-        <Map s="S1|Neighborhoods|Muscle_int_Muscle_cell|C1|P*SA interstitial -&gt; intracellular" id="1324" />
-        <Map s="S1|Neighborhoods|Muscle_int_Muscle_cell|C1|P*SA intracellular -&gt; interstitial" id="1325" />
-        <Map s="S1|Organism|Muscle|Interstitial|..|Volume" id="1326" />
-        <Map s="S1|Neighborhoods|Muscle_pls_Muscle_bc|Surface area (blood cells/plasma)" id="1327" />
-        <Map s="S1|Organism|Muscle|Plasma|..|Fraction vascular" id="1328" />
-        <Map s="S1|Organism|Muscle|Plasma|..|Volume" id="1329" />
-        <Map s="S1|Neighborhoods|Muscle_pls_Muscle_int|C1|P (plasma&lt;-&gt;interstitial)" id="1330" />
-        <Map s="S1|Organism|Muscle|Plasma|..|Blood flow rate" id="1331" />
-        <Map s="S1|Organism|Muscle|BloodCells|..|Blood flow rate" id="1332" />
-        <Map s="S1|Organism|Pancreas|BloodCells|C1|Concentration" id="1333" />
-        <Map s="S1|Organism|Pancreas|Plasma|C1|Concentration" id="1334" />
-        <Map s="S1|Neighborhoods|Pancreas_pls_Pancreas_bc|Surface area (blood cells/plasma)" id="1335" />
-        <Map s="S1|Organism|Pancreas|Plasma|..|Fraction vascular" id="1336" />
-        <Map s="S1|Organism|Pancreas|Plasma|..|Volume" id="1337" />
-        <Map s="S1|Organism|Pancreas|Interstitial|C1|Concentration" id="1338" />
-        <Map s="S1|Neighborhoods|Pancreas_pls_Pancreas_int|C1|P (plasma&lt;-&gt;interstitial)" id="1339" />
-        <Map s="S1|Neighborhoods|Pancreas_pls_Pancreas_int|C1|Partition coefficient (interstitial/plasma)" id="1340" />
-        <Map s="S1|Organism|Pancreas|Plasma|..|Blood flow rate" id="1341" />
-        <Map s="S1|Organism|Pancreas|Interstitial|..|Vf (lipid)" id="1342" />
-        <Map s="S1|Organism|Pancreas|Interstitial|..|Vf (protein)" id="1343" />
-        <Map s="S1|Organism|Pancreas|Interstitial|..|Vf (water)" id="1344" />
-        <Map s="S1|Organism|Pancreas|Intracellular|C1|Concentration" id="1345" />
-        <Map s="S1|Neighborhoods|Pancreas_int_Pancreas_cell|C1|P*SA interstitial -&gt; intracellular" id="1346" />
-        <Map s="S1|Neighborhoods|Pancreas_int_Pancreas_cell|C1|P*SA intracellular -&gt; interstitial" id="1347" />
-        <Map s="S1|Organism|Pancreas|Interstitial|..|Volume" id="1348" />
-        <Map s="S1|Organism|Pancreas|BloodCells|..|Blood flow rate" id="1349" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|Rectum|Intracellular|pH" id="1350" />
-        <Map s="S1|Organism|Lumen|Rectum|Effective surface area enhancement factor" id="1351" />
-        <Map s="S1|Organism|Lumen|Rectum|Geometric surface area" id="1352" />
-        <Map s="S1|Organism|Lumen|Rectum|Liquid" id="1353" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|Rectum|Intracellular|C1|Concentration" id="1354" />
-        <Map s="S1|Neighborhoods|Lumen_rect_Rectum_cell|C1|P_int_trans_cell_lum_factor" id="1355" />
-        <Map s="S1|Neighborhoods|Lumen_rect_Rectum_cell|C1|P_int_trans_lum_cell_factor" id="1356" />
-        <Map s="S1|Organism|Lumen|Rectum|C1|Solubility" id="1357" />
-        <Map s="S1|Organism|Lumen|Rectum|..|Transcellular absorption sink condition" id="1358" />
-        <Map s="S1|Neighborhoods|Rectum_int_Rectum_cell|C1|Partition coefficient (intracellular/plasma)" id="1359" />
-        <Map s="S1|Neighborhoods|Lumen_rect_Rectum_cell|C1|DrugAbsorption_trans|ProcessRate" id="1360" />
-        <Map s="S1|Organism|Lumen|Rectum|pH" id="1361" />
-        <Map s="S1|Neighborhoods|Lumen_rect_Rectum_cell|C1|Drug absorption rate (lumen to mucosa)" id="1362" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|Rectum|Plasma|C1|Concentration" id="1363" />
-        <Map s="S1|Neighborhoods|Rectum_pls_PortalVein_pls|C1|Mass transfer rate (mucosa to portal vein plasma)" id="1364" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|Rectum|BloodCells|C1|Concentration" id="1365" />
-        <Map s="S1|Neighborhoods|Rectum_bc_PortalVein_bc|C1|Mass transfer rate (mucosa to portal vein blood cells)" id="1366" />
-        <Map s="S1|Organism|Lumen|Rectum|..|Paracellular absorption sink condition" id="1367" />
-        <Map s="S1|Organism|PortalVein|Plasma|..|Blood flow rate" id="1368" />
-        <Map s="S1|Organism|PortalVein|Plasma|C1|Concentration" id="1369" />
-        <Map s="S1|Organism|PortalVein|BloodCells|C1|Concentration" id="1370" />
-        <Map s="S1|Neighborhoods|PortalVein_pls_PortalVein_bc|Surface area (blood cells/plasma)" id="1371" />
-        <Map s="S1|Organism|PortalVein|Plasma|..|Volume" id="1372" />
-        <Map s="S1|Organism|PortalVein|BloodCells|..|Blood flow rate" id="1373" />
-        <Map s="S1|Organism|Skin|Plasma|..|Blood flow rate" id="1374" />
-        <Map s="S1|Neighborhoods|Skin_pls_Skin_bc|Surface area (blood cells/plasma)" id="1375" />
-        <Map s="S1|Organism|Skin|Plasma|..|Fraction vascular" id="1376" />
-        <Map s="S1|Organism|Skin|Plasma|..|Volume" id="1377" />
-        <Map s="S1|Organism|Skin|Interstitial|..|Vf (lipid)" id="1378" />
-        <Map s="S1|Organism|Skin|Interstitial|..|Vf (protein)" id="1379" />
-        <Map s="S1|Organism|Skin|Interstitial|..|Vf (water)" id="1380" />
-        <Map s="S1|Neighborhoods|Skin_pls_Skin_int|C1|Partition coefficient (interstitial/plasma)" id="1381" />
-        <Map s="S1|Organism|Skin|Intracellular|C1|Concentration" id="1382" />
-        <Map s="S1|Organism|Skin|Interstitial|C1|Concentration" id="1383" />
-        <Map s="S1|Neighborhoods|Skin_int_Skin_cell|C1|P*SA interstitial -&gt; intracellular" id="1384" />
-        <Map s="S1|Neighborhoods|Skin_int_Skin_cell|C1|P*SA intracellular -&gt; interstitial" id="1385" />
-        <Map s="S1|Organism|Skin|Interstitial|..|Volume" id="1386" />
-        <Map s="S1|Neighborhoods|Skin_pls_Skin_int|C1|P (plasma&lt;-&gt;interstitial)" id="1387" />
-        <Map s="S1|Organism|Skin|BloodCells|..|Blood flow rate" id="1388" />
-        <Map s="S1|Organism|Spleen|Plasma|..|Blood flow rate" id="1389" />
-        <Map s="S1|Organism|Spleen|Plasma|C1|Concentration" id="1390" />
-        <Map s="S1|Organism|Spleen|Interstitial|..|Vf (lipid)" id="1391" />
-        <Map s="S1|Organism|Spleen|Interstitial|..|Vf (protein)" id="1392" />
-        <Map s="S1|Organism|Spleen|Interstitial|..|Vf (water)" id="1393" />
-        <Map s="S1|Neighborhoods|Spleen_pls_Spleen_int|C1|Partition coefficient (interstitial/plasma)" id="1394" />
-        <Map s="S1|Organism|Spleen|Intracellular|C1|Concentration" id="1395" />
-        <Map s="S1|Organism|Spleen|Interstitial|C1|Concentration" id="1396" />
-        <Map s="S1|Neighborhoods|Spleen_int_Spleen_cell|C1|P*SA interstitial -&gt; intracellular" id="1397" />
-        <Map s="S1|Neighborhoods|Spleen_int_Spleen_cell|C1|P*SA intracellular -&gt; interstitial" id="1398" />
-        <Map s="S1|Organism|Spleen|Interstitial|..|Volume" id="1399" />
-        <Map s="S1|Neighborhoods|Spleen_pls_Spleen_int|C1|P (plasma&lt;-&gt;interstitial)" id="1400" />
-        <Map s="S1|Organism|Spleen|Plasma|..|Fraction vascular" id="1401" />
-        <Map s="S1|Organism|Spleen|Plasma|..|Volume" id="1402" />
-        <Map s="S1|Organism|Spleen|BloodCells|C1|Concentration" id="1403" />
-        <Map s="S1|Neighborhoods|Spleen_pls_Spleen_bc|Surface area (blood cells/plasma)" id="1404" />
-        <Map s="S1|Organism|Spleen|BloodCells|..|Blood flow rate" id="1405" />
-        <Map s="..|SalivaPlasmaRatio" id="1406" />
-        <Map s="R" id="1407" />
-        <Map s="S1|Organism|Saliva|Saliva|pH (saliva)" id="1408" />
-        <Map s="pH_slv" id="1409" />
-        <Map s="S1|Organism|pH (plasma)" id="1410" />
-        <Map s="pH_PLS" id="1411" />
-        <Map s="S1|Organism|Saliva|SalivaGland|..|Saliva flow rate" id="1412" />
-        <Map s="Q_slv" id="1413" />
-        <Map s="S1|Organism|Saliva|SalivaGland|..|..|ArterialBlood|Plasma|C1|Concentration" id="1414" />
-        <Map s="S1|Organism|Saliva|Saliva|C1|Concentration" id="1415" />
-        <Map s="C_slv" id="1416" />
-        <Map s="S1|Neighborhoods|Saliva_slv_Saliva_slv|C1|Partition coefficient (intracellular/plasma)" id="1417" />
-        <Map s="K_slv_pls" id="1418" />
-        <Map s="S1|Organism|SmallIntestine|Mucosa|Duodenum|BloodCells|C1|Concentration" id="1419" />
-        <Map s="S1|Organism|SmallIntestine|Mucosa|Duodenum|Plasma|C1|Concentration" id="1420" />
-        <Map s="S1|Neighborhoods|Duodenum_pls_Duodenum_bc|Surface area (blood cells/plasma)" id="1421" />
-        <Map s="S1|Organism|SmallIntestine|Mucosa|Duodenum|Plasma|..|Fraction vascular" id="1422" />
-        <Map s="S1|Organism|SmallIntestine|Mucosa|Duodenum|Plasma|..|Volume" id="1423" />
-        <Map s="S1|Organism|SmallIntestine|Mucosa|Duodenum|Interstitial|C1|Concentration" id="1424" />
-        <Map s="S1|Neighborhoods|Duodenum_pls_Duodenum_int|C1|P (plasma&lt;-&gt;interstitial)" id="1425" />
-        <Map s="S1|Neighborhoods|Duodenum_pls_Duodenum_int|C1|Partition coefficient (interstitial/plasma)" id="1426" />
-        <Map s="S1|C1|Mucosa permeability scale factor (transcellular)" id="1427" />
-        <Map s="P_int_scalefactor" id="1428" />
-        <Map s="S1|Organism|SmallIntestine|Mucosa|Duodenum|Interstitial|..|Vf (lipid)" id="1429" />
-        <Map s="S1|Organism|SmallIntestine|Mucosa|Duodenum|Interstitial|..|Vf (protein)" id="1430" />
-        <Map s="S1|Organism|SmallIntestine|Mucosa|Duodenum|Interstitial|..|Vf (water)" id="1431" />
-        <Map s="S1|Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|C1|Concentration" id="1432" />
-        <Map s="S1|Neighborhoods|Duodenum_int_Duodenum_cell|C1|P*SA interstitial -&gt; intracellular" id="1433" />
-        <Map s="S1|Neighborhoods|Duodenum_int_Duodenum_cell|C1|P*SA intracellular -&gt; interstitial" id="1434" />
-        <Map s="S1|Organism|Lumen|Duodenum|Effective surface area enhancement factor" id="1435" />
-        <Map s="S1|Organism|Lumen|Duodenum|Geometric surface area" id="1436" />
-        <Map s="S1|Organism|Lumen|Duodenum|Microvilli factor" id="1437" />
-        <Map s="MicrovilliFactor" id="1438" />
-        <Map s="S1|Organism|SmallIntestine|Mucosa|UpperJejunum|Interstitial|..|Vf (lipid)" id="1439" />
-        <Map s="S1|Organism|SmallIntestine|Mucosa|UpperJejunum|Interstitial|..|Vf (protein)" id="1440" />
-        <Map s="S1|Organism|SmallIntestine|Mucosa|UpperJejunum|Interstitial|..|Vf (water)" id="1441" />
-        <Map s="S1|Organism|SmallIntestine|Mucosa|UpperJejunum|Interstitial|C1|Concentration" id="1442" />
-        <Map s="S1|Neighborhoods|UpperJejunum_int_UpperJejunum_cell|C1|P*SA interstitial -&gt; intracellular" id="1443" />
-        <Map s="S1|Neighborhoods|UpperJejunum_int_UpperJejunum_cell|C1|P*SA intracellular -&gt; interstitial" id="1444" />
-        <Map s="S1|Organism|Lumen|UpperJejunum|Microvilli factor" id="1445" />
-        <Map s="S1|Neighborhoods|UpperJejunum_pls_UpperJejunum_bc|Surface area (blood cells/plasma)" id="1446" />
-        <Map s="S1|Organism|SmallIntestine|Mucosa|UpperJejunum|Plasma|..|Fraction vascular" id="1447" />
-        <Map s="S1|Organism|SmallIntestine|Mucosa|UpperJejunum|Plasma|..|Volume" id="1448" />
-        <Map s="S1|Neighborhoods|UpperJejunum_pls_UpperJejunum_int|C1|P (plasma&lt;-&gt;interstitial)" id="1449" />
-        <Map s="S1|Neighborhoods|UpperJejunum_pls_UpperJejunum_int|C1|Partition coefficient (interstitial/plasma)" id="1450" />
-        <Map s="S1|Organism|SmallIntestine|Mucosa|LowerJejunum|Interstitial|C1|Concentration" id="1451" />
-        <Map s="S1|Neighborhoods|LowerJejunum_pls_LowerJejunum_int|C1|P (plasma&lt;-&gt;interstitial)" id="1452" />
-        <Map s="S1|Neighborhoods|LowerJejunum_pls_LowerJejunum_int|C1|Partition coefficient (interstitial/plasma)" id="1453" />
-        <Map s="S1|Organism|SmallIntestine|Mucosa|LowerJejunum|Plasma|..|Fraction vascular" id="1454" />
-        <Map s="S1|Organism|SmallIntestine|Mucosa|LowerJejunum|Plasma|..|Volume" id="1455" />
-        <Map s="S1|Neighborhoods|LowerJejunum_pls_LowerJejunum_bc|Surface area (blood cells/plasma)" id="1456" />
-        <Map s="S1|Organism|SmallIntestine|Mucosa|LowerJejunum|Interstitial|..|Vf (lipid)" id="1457" />
-        <Map s="S1|Organism|SmallIntestine|Mucosa|LowerJejunum|Interstitial|..|Vf (protein)" id="1458" />
-        <Map s="S1|Organism|SmallIntestine|Mucosa|LowerJejunum|Interstitial|..|Vf (water)" id="1459" />
-        <Map s="S1|Neighborhoods|LowerJejunum_int_LowerJejunum_cell|C1|P*SA interstitial -&gt; intracellular" id="1460" />
-        <Map s="S1|Neighborhoods|LowerJejunum_int_LowerJejunum_cell|C1|P*SA intracellular -&gt; interstitial" id="1461" />
-        <Map s="S1|Organism|Lumen|LowerJejunum|Microvilli factor" id="1462" />
-        <Map s="S1|Organism|SmallIntestine|Mucosa|UpperIleum|Interstitial|..|Vf (lipid)" id="1463" />
-        <Map s="S1|Organism|SmallIntestine|Mucosa|UpperIleum|Interstitial|..|Vf (protein)" id="1464" />
-        <Map s="S1|Organism|SmallIntestine|Mucosa|UpperIleum|Interstitial|..|Vf (water)" id="1465" />
-        <Map s="S1|Organism|SmallIntestine|Mucosa|UpperIleum|Interstitial|C1|Concentration" id="1466" />
-        <Map s="S1|Neighborhoods|UpperIleum_int_UpperIleum_cell|C1|P*SA interstitial -&gt; intracellular" id="1467" />
-        <Map s="S1|Neighborhoods|UpperIleum_int_UpperIleum_cell|C1|P*SA intracellular -&gt; interstitial" id="1468" />
-        <Map s="S1|Organism|Lumen|UpperIleum|Microvilli factor" id="1469" />
-        <Map s="S1|Neighborhoods|UpperIleum_pls_UpperIleum_bc|Surface area (blood cells/plasma)" id="1470" />
-        <Map s="S1|Organism|SmallIntestine|Mucosa|UpperIleum|Plasma|..|Fraction vascular" id="1471" />
-        <Map s="S1|Organism|SmallIntestine|Mucosa|UpperIleum|Plasma|..|Volume" id="1472" />
-        <Map s="S1|Neighborhoods|UpperIleum_pls_UpperIleum_int|C1|P (plasma&lt;-&gt;interstitial)" id="1473" />
-        <Map s="S1|Neighborhoods|UpperIleum_pls_UpperIleum_int|C1|Partition coefficient (interstitial/plasma)" id="1474" />
-        <Map s="S1|Neighborhoods|LowerIleum_pls_LowerIleum_bc|Surface area (blood cells/plasma)" id="1475" />
-        <Map s="S1|Organism|SmallIntestine|Mucosa|LowerIleum|Plasma|..|Fraction vascular" id="1476" />
-        <Map s="S1|Organism|SmallIntestine|Mucosa|LowerIleum|Plasma|..|Volume" id="1477" />
-        <Map s="S1|Organism|SmallIntestine|Mucosa|LowerIleum|Interstitial|..|Vf (lipid)" id="1478" />
-        <Map s="S1|Organism|SmallIntestine|Mucosa|LowerIleum|Interstitial|..|Vf (protein)" id="1479" />
-        <Map s="S1|Organism|SmallIntestine|Mucosa|LowerIleum|Interstitial|..|Vf (water)" id="1480" />
-        <Map s="S1|Organism|SmallIntestine|Mucosa|LowerIleum|Interstitial|C1|Concentration" id="1481" />
-        <Map s="S1|Neighborhoods|LowerIleum_int_LowerIleum_cell|C1|P*SA interstitial -&gt; intracellular" id="1482" />
-        <Map s="S1|Neighborhoods|LowerIleum_int_LowerIleum_cell|C1|P*SA intracellular -&gt; interstitial" id="1483" />
-        <Map s="S1|Organism|Lumen|LowerIleum|Microvilli factor" id="1484" />
-        <Map s="S1|Neighborhoods|LowerIleum_pls_LowerIleum_int|C1|P (plasma&lt;-&gt;interstitial)" id="1485" />
-        <Map s="S1|Neighborhoods|LowerIleum_pls_LowerIleum_int|C1|Partition coefficient (interstitial/plasma)" id="1486" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|Caecum|Interstitial|C1|Concentration" id="1487" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|Caecum|Plasma|C1|Concentration" id="1488" />
-        <Map s="S1|Neighborhoods|Caecum_pls_Caecum_int|C1|P (plasma&lt;-&gt;interstitial)" id="1489" />
-        <Map s="S1|Neighborhoods|Caecum_pls_Caecum_int|C1|Partition coefficient (interstitial/plasma)" id="1490" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|Caecum|Plasma|..|Fraction vascular" id="1491" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|Caecum|Plasma|..|Volume" id="1492" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|Caecum|BloodCells|C1|Concentration" id="1493" />
-        <Map s="S1|Neighborhoods|Caecum_pls_Caecum_bc|Surface area (blood cells/plasma)" id="1494" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|Caecum|Interstitial|..|Vf (lipid)" id="1495" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|Caecum|Interstitial|..|Vf (protein)" id="1496" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|Caecum|Interstitial|..|Vf (water)" id="1497" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|Caecum|Intracellular|C1|Concentration" id="1498" />
-        <Map s="S1|Neighborhoods|Caecum_int_Caecum_cell|C1|P*SA interstitial -&gt; intracellular" id="1499" />
-        <Map s="S1|Neighborhoods|Caecum_int_Caecum_cell|C1|P*SA intracellular -&gt; interstitial" id="1500" />
-        <Map s="S1|Organism|Lumen|Caecum|Effective surface area enhancement factor" id="1501" />
-        <Map s="S1|Organism|Lumen|Caecum|Geometric surface area" id="1502" />
-        <Map s="S1|Organism|Lumen|Caecum|Microvilli factor" id="1503" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|ColonAscendens|BloodCells|C1|Concentration" id="1504" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|ColonAscendens|Plasma|C1|Concentration" id="1505" />
-        <Map s="S1|Neighborhoods|ColonAscendens_pls_ColonAscendens_bc|Surface area (blood cells/plasma)" id="1506" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|ColonAscendens|Plasma|..|Fraction vascular" id="1507" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|ColonAscendens|Plasma|..|Volume" id="1508" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|ColonAscendens|Interstitial|..|Vf (lipid)" id="1509" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|ColonAscendens|Interstitial|..|Vf (protein)" id="1510" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|ColonAscendens|Interstitial|..|Vf (water)" id="1511" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|C1|Concentration" id="1512" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|ColonAscendens|Interstitial|C1|Concentration" id="1513" />
-        <Map s="S1|Neighborhoods|ColonAscendens_int_ColonAscendens_cell|C1|P*SA interstitial -&gt; intracellular" id="1514" />
-        <Map s="S1|Neighborhoods|ColonAscendens_int_ColonAscendens_cell|C1|P*SA intracellular -&gt; interstitial" id="1515" />
-        <Map s="S1|Organism|Lumen|ColonAscendens|Effective surface area enhancement factor" id="1516" />
-        <Map s="S1|Organism|Lumen|ColonAscendens|Geometric surface area" id="1517" />
-        <Map s="S1|Organism|Lumen|ColonAscendens|Microvilli factor" id="1518" />
-        <Map s="S1|Neighborhoods|ColonAscendens_pls_ColonAscendens_int|C1|P (plasma&lt;-&gt;interstitial)" id="1519" />
-        <Map s="S1|Neighborhoods|ColonAscendens_pls_ColonAscendens_int|C1|Partition coefficient (interstitial/plasma)" id="1520" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|ColonTransversum|Interstitial|..|Vf (lipid)" id="1521" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|ColonTransversum|Interstitial|..|Vf (protein)" id="1522" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|ColonTransversum|Interstitial|..|Vf (water)" id="1523" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|C1|Concentration" id="1524" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|ColonTransversum|Interstitial|C1|Concentration" id="1525" />
-        <Map s="S1|Neighborhoods|ColonTransversum_int_ColonTransversum_cell|C1|P*SA interstitial -&gt; intracellular" id="1526" />
-        <Map s="S1|Neighborhoods|ColonTransversum_int_ColonTransversum_cell|C1|P*SA intracellular -&gt; interstitial" id="1527" />
-        <Map s="S1|Organism|Lumen|ColonTransversum|Effective surface area enhancement factor" id="1528" />
-        <Map s="S1|Organism|Lumen|ColonTransversum|Geometric surface area" id="1529" />
-        <Map s="S1|Organism|Lumen|ColonTransversum|Microvilli factor" id="1530" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|ColonTransversum|BloodCells|C1|Concentration" id="1531" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|ColonTransversum|Plasma|C1|Concentration" id="1532" />
-        <Map s="S1|Neighborhoods|ColonTransversum_pls_ColonTransversum_bc|Surface area (blood cells/plasma)" id="1533" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|ColonTransversum|Plasma|..|Fraction vascular" id="1534" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|ColonTransversum|Plasma|..|Volume" id="1535" />
-        <Map s="S1|Neighborhoods|ColonTransversum_pls_ColonTransversum_int|C1|P (plasma&lt;-&gt;interstitial)" id="1536" />
-        <Map s="S1|Neighborhoods|ColonTransversum_pls_ColonTransversum_int|C1|Partition coefficient (interstitial/plasma)" id="1537" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|ColonDescendens|Interstitial|C1|Concentration" id="1538" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|ColonDescendens|Plasma|C1|Concentration" id="1539" />
-        <Map s="S1|Neighborhoods|ColonDescendens_pls_ColonDescendens_int|C1|P (plasma&lt;-&gt;interstitial)" id="1540" />
-        <Map s="S1|Neighborhoods|ColonDescendens_pls_ColonDescendens_int|C1|Partition coefficient (interstitial/plasma)" id="1541" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|ColonDescendens|Plasma|..|Fraction vascular" id="1542" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|ColonDescendens|Plasma|..|Volume" id="1543" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|ColonDescendens|BloodCells|C1|Concentration" id="1544" />
-        <Map s="S1|Neighborhoods|ColonDescendens_pls_ColonDescendens_bc|Surface area (blood cells/plasma)" id="1545" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|ColonDescendens|Interstitial|..|Vf (lipid)" id="1546" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|ColonDescendens|Interstitial|..|Vf (protein)" id="1547" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|ColonDescendens|Interstitial|..|Vf (water)" id="1548" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|C1|Concentration" id="1549" />
-        <Map s="S1|Neighborhoods|ColonDescendens_int_ColonDescendens_cell|C1|P*SA interstitial -&gt; intracellular" id="1550" />
-        <Map s="S1|Neighborhoods|ColonDescendens_int_ColonDescendens_cell|C1|P*SA intracellular -&gt; interstitial" id="1551" />
-        <Map s="S1|Organism|Lumen|ColonDescendens|Effective surface area enhancement factor" id="1552" />
-        <Map s="S1|Organism|Lumen|ColonDescendens|Geometric surface area" id="1553" />
-        <Map s="S1|Organism|Lumen|ColonDescendens|Microvilli factor" id="1554" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|ColonSigmoid|Interstitial|C1|Concentration" id="1555" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|ColonSigmoid|Plasma|C1|Concentration" id="1556" />
-        <Map s="S1|Neighborhoods|ColonSigmoid_pls_ColonSigmoid_int|C1|P (plasma&lt;-&gt;interstitial)" id="1557" />
-        <Map s="S1|Neighborhoods|ColonSigmoid_pls_ColonSigmoid_int|C1|Partition coefficient (interstitial/plasma)" id="1558" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|ColonSigmoid|Plasma|..|Fraction vascular" id="1559" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|ColonSigmoid|Plasma|..|Volume" id="1560" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|ColonSigmoid|BloodCells|C1|Concentration" id="1561" />
-        <Map s="S1|Neighborhoods|ColonSigmoid_pls_ColonSigmoid_bc|Surface area (blood cells/plasma)" id="1562" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|ColonSigmoid|Interstitial|..|Vf (lipid)" id="1563" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|ColonSigmoid|Interstitial|..|Vf (protein)" id="1564" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|ColonSigmoid|Interstitial|..|Vf (water)" id="1565" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|C1|Concentration" id="1566" />
-        <Map s="S1|Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|C1|P*SA interstitial -&gt; intracellular" id="1567" />
-        <Map s="S1|Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|C1|P*SA intracellular -&gt; interstitial" id="1568" />
-        <Map s="S1|Organism|Lumen|ColonSigmoid|Effective surface area enhancement factor" id="1569" />
-        <Map s="S1|Organism|Lumen|ColonSigmoid|Geometric surface area" id="1570" />
-        <Map s="S1|Organism|Lumen|ColonSigmoid|Microvilli factor" id="1571" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|Rectum|Interstitial|C1|Concentration" id="1572" />
-        <Map s="S1|Neighborhoods|Rectum_pls_Rectum_int|C1|P (plasma&lt;-&gt;interstitial)" id="1573" />
-        <Map s="S1|Neighborhoods|Rectum_pls_Rectum_int|C1|Partition coefficient (interstitial/plasma)" id="1574" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|Rectum|Plasma|..|Fraction vascular" id="1575" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|Rectum|Plasma|..|Volume" id="1576" />
-        <Map s="S1|Neighborhoods|Rectum_pls_Rectum_bc|Surface area (blood cells/plasma)" id="1577" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|Rectum|Interstitial|..|Vf (lipid)" id="1578" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|Rectum|Interstitial|..|Vf (protein)" id="1579" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|Rectum|Interstitial|..|Vf (water)" id="1580" />
-        <Map s="S1|Neighborhoods|Rectum_int_Rectum_cell|C1|P*SA interstitial -&gt; intracellular" id="1581" />
-        <Map s="S1|Neighborhoods|Rectum_int_Rectum_cell|C1|P*SA intracellular -&gt; interstitial" id="1582" />
-        <Map s="S1|Organism|Lumen|Rectum|Microvilli factor" id="1583" />
-        <Map s="S1|Neighborhoods|Caecum_bc_PortalVein_bc|C1|Mass transfer rate (mucosa to portal vein blood cells)" id="1584" />
-        <Map s="S1|Organism|Lumen|Caecum|Liquid" id="1585" />
-        <Map s="S1|Neighborhoods|Lumen_cae_Caecum_cell|C1|P_int_trans_cell_lum_factor" id="1586" />
-        <Map s="S1|Neighborhoods|Lumen_cae_Caecum_cell|C1|P_int_trans_lum_cell_factor" id="1587" />
-        <Map s="S1|Organism|Lumen|Caecum|C1|Solubility" id="1588" />
-        <Map s="S1|Organism|Lumen|Caecum|..|Transcellular absorption sink condition" id="1589" />
-        <Map s="S1|Neighborhoods|Caecum_int_Caecum_cell|C1|Partition coefficient (intracellular/plasma)" id="1590" />
-        <Map s="S1|Organism|Lumen|Caecum|pH" id="1591" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|Caecum|Intracellular|pH" id="1592" />
-        <Map s="S1|Neighborhoods|Lumen_cae_Caecum_cell|C1|DrugAbsorption_trans|ProcessRate" id="1593" />
-        <Map s="S1|Neighborhoods|Lumen_cae_Caecum_cell|C1|Drug absorption rate (lumen to mucosa)" id="1594" />
-        <Map s="S1|Organism|Lumen|Caecum|..|Paracellular absorption sink condition" id="1595" />
-        <Map s="S1|Neighborhoods|Caecum_pls_PortalVein_pls|C1|Mass transfer rate (mucosa to portal vein plasma)" id="1596" />
-        <Map s="S1|Organism|Lumen|ColonTransversum|Liquid" id="1597" />
-        <Map s="S1|Organism|Lumen|ColonTransversum|C1|Solubility" id="1598" />
-        <Map s="S1|Organism|Lumen|ColonTransversum|..|Paracellular absorption sink condition" id="1599" />
-        <Map s="S1|Neighborhoods|ColonAscendens_bc_PortalVein_bc|C1|Mass transfer rate (mucosa to portal vein blood cells)" id="1600" />
-        <Map s="S1|Neighborhoods|ColonAscendens_pls_PortalVein_pls|C1|Mass transfer rate (mucosa to portal vein plasma)" id="1601" />
-        <Map s="S1|Neighborhoods|ColonSigmoid_pls_PortalVein_pls|C1|Mass transfer rate (mucosa to portal vein plasma)" id="1602" />
-        <Map s="S1|Organism|Lumen|ColonSigmoid|Liquid" id="1603" />
-        <Map s="S1|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|C1|P_int_trans_cell_lum_factor" id="1604" />
-        <Map s="S1|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|C1|P_int_trans_lum_cell_factor" id="1605" />
-        <Map s="S1|Organism|Lumen|ColonSigmoid|C1|Solubility" id="1606" />
-        <Map s="S1|Organism|Lumen|ColonSigmoid|..|Transcellular absorption sink condition" id="1607" />
-        <Map s="S1|Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|C1|Partition coefficient (intracellular/plasma)" id="1608" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|pH" id="1609" />
-        <Map s="S1|Organism|Lumen|ColonSigmoid|pH" id="1610" />
-        <Map s="S1|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|C1|DrugAbsorption_trans|ProcessRate" id="1611" />
-        <Map s="S1|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|C1|Drug absorption rate (lumen to mucosa)" id="1612" />
-        <Map s="S1|Organism|Lumen|ColonSigmoid|..|Paracellular absorption sink condition" id="1613" />
-        <Map s="S1|Neighborhoods|ColonDescendens_bc_PortalVein_bc|C1|Mass transfer rate (mucosa to portal vein blood cells)" id="1614" />
-        <Map s="S1|Neighborhoods|ColonDescendens_pls_PortalVein_pls|C1|Mass transfer rate (mucosa to portal vein plasma)" id="1615" />
-        <Map s="S1|Neighborhoods|ColonSigmoid_bc_PortalVein_bc|C1|Mass transfer rate (mucosa to portal vein blood cells)" id="1616" />
-        <Map s="S1|Organism|Lumen|ColonDescendens|pH" id="1617" />
-        <Map s="S1|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|C1|DrugAbsorption_trans|ProcessRate" id="1618" />
-        <Map s="S1|Neighborhoods|ColonDescendens_int_ColonDescendens_cell|C1|Partition coefficient (intracellular/plasma)" id="1619" />
-        <Map s="S1|Organism|Lumen|ColonDescendens|Liquid" id="1620" />
-        <Map s="S1|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|C1|P_int_trans_cell_lum_factor" id="1621" />
-        <Map s="S1|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|C1|P_int_trans_lum_cell_factor" id="1622" />
-        <Map s="S1|Organism|Lumen|ColonDescendens|C1|Solubility" id="1623" />
-        <Map s="S1|Organism|Lumen|ColonDescendens|..|Transcellular absorption sink condition" id="1624" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|pH" id="1625" />
-        <Map s="S1|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|C1|Drug absorption rate (lumen to mucosa)" id="1626" />
-        <Map s="S1|Organism|Lumen|ColonDescendens|..|Paracellular absorption sink condition" id="1627" />
-        <Map s="S1|Neighborhoods|ColonTransversum_bc_PortalVein_bc|C1|Mass transfer rate (mucosa to portal vein blood cells)" id="1628" />
-        <Map s="S1|Neighborhoods|ColonTransversum_pls_PortalVein_pls|C1|Mass transfer rate (mucosa to portal vein plasma)" id="1629" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|pH" id="1630" />
-        <Map s="S1|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|C1|P_int_trans_cell_lum_factor" id="1631" />
-        <Map s="S1|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|C1|P_int_trans_lum_cell_factor" id="1632" />
-        <Map s="S1|Organism|Lumen|ColonTransversum|..|Transcellular absorption sink condition" id="1633" />
-        <Map s="S1|Neighborhoods|ColonTransversum_int_ColonTransversum_cell|C1|Partition coefficient (intracellular/plasma)" id="1634" />
-        <Map s="S1|Organism|Lumen|ColonTransversum|pH" id="1635" />
-        <Map s="S1|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|C1|DrugAbsorption_trans|ProcessRate" id="1636" />
-        <Map s="S1|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|C1|Drug absorption rate (lumen to mucosa)" id="1637" />
-        <Map s="S1|Organism|Lumen|ColonAscendens|pH" id="1638" />
-        <Map s="S1|Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|pH" id="1639" />
-        <Map s="S1|Organism|Lumen|ColonAscendens|Liquid" id="1640" />
-        <Map s="S1|Neighborhoods|Lumen_colasc_ColonAscendens_cell|C1|P_int_trans_cell_lum_factor" id="1641" />
-        <Map s="S1|Neighborhoods|Lumen_colasc_ColonAscendens_cell|C1|P_int_trans_lum_cell_factor" id="1642" />
-        <Map s="S1|Organism|Lumen|ColonAscendens|C1|Solubility" id="1643" />
-        <Map s="S1|Organism|Lumen|ColonAscendens|..|Transcellular absorption sink condition" id="1644" />
-        <Map s="S1|Neighborhoods|ColonAscendens_int_ColonAscendens_cell|C1|Partition coefficient (intracellular/plasma)" id="1645" />
-        <Map s="S1|Neighborhoods|Lumen_colasc_ColonAscendens_cell|C1|DrugAbsorption_trans|ProcessRate" id="1646" />
-        <Map s="S1|Neighborhoods|Lumen_colasc_ColonAscendens_cell|C1|Drug absorption rate (lumen to mucosa)" id="1647" />
-        <Map s="S1|Organism|Lumen|ColonAscendens|..|Paracellular absorption sink condition" id="1648" />
-        <Map s="S1|Neighborhoods|Duodenum_bc_PortalVein_bc|C1|Mass transfer rate (mucosa to portal vein blood cells)" id="1649" />
-        <Map s="S1|Neighborhoods|Duodenum_pls_PortalVein_pls|C1|Mass transfer rate (mucosa to portal vein plasma)" id="1650" />
-        <Map s="S1|Organism|Lumen|Duodenum|pH" id="1651" />
-        <Map s="S1|Neighborhoods|Lumen_duo_Duodenum_cell|C1|DrugAbsorption_trans|ProcessRate" id="1652" />
-        <Map s="S1|Organism|Lumen|Duodenum|Liquid" id="1653" />
-        <Map s="S1|Neighborhoods|Lumen_duo_Duodenum_cell|C1|P_int_trans_cell_lum_factor" id="1654" />
-        <Map s="S1|Neighborhoods|Lumen_duo_Duodenum_cell|C1|P_int_trans_lum_cell_factor" id="1655" />
-        <Map s="S1|Organism|Lumen|Duodenum|C1|Solubility" id="1656" />
-        <Map s="S1|Organism|Lumen|Duodenum|..|Transcellular absorption sink condition" id="1657" />
-        <Map s="S1|Neighborhoods|Duodenum_int_Duodenum_cell|C1|Partition coefficient (intracellular/plasma)" id="1658" />
-        <Map s="S1|Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|pH" id="1659" />
-        <Map s="S1|Neighborhoods|Lumen_duo_Duodenum_cell|C1|Drug absorption rate (lumen to mucosa)" id="1660" />
-        <Map s="S1|Organism|Lumen|Duodenum|..|Paracellular absorption sink condition" id="1661" />
-        <Map s="S1|Neighborhoods|Lumen_duo_Duodenum_pls|C1|DrugAbsorption_para|ProcessRate" id="1662" />
-        <Map s="S1|Neighborhoods|Lumen_duo_Duodenum_pls|C1|Drug absorption rate (lumen to mucosa)" id="1663" />
-        <Map s="S1|C1|Specific intestinal permeability (transcellular)" id="1664" />
-        <Map s="P_int_InVitro" id="1665" />
-        <Map s="..|Default Intestinal permeability (transcellular)" id="1666" />
-        <Map s="P_int_trans_default" id="1667" />
-        <Map s="..|Intestinal permeability (transcellular)" id="1668" />
-        <Map s="S1|C1|P_pls_bc_factor" id="1669" />
-        <Map s="P_pls_rbc_factor" id="1670" />
-        <Map s="S1|C1|Calculated specific intestinal permeability (transcellular)" id="1671" />
-        <Map s="S1|Organism|Vf (lipid, blood cells)" id="1672" />
-        <Map s="f_lipids_rbc" id="1673" />
-        <Map s="S1|Organism|Vf (protein,blood cells)" id="1674" />
-        <Map s="f_proteins_rbc" id="1675" />
-        <Map s="S1|Organism|Vf (water,blood cells)" id="1676" />
-        <Map s="f_water_rbc" id="1677" />
-        <Map s="S1|C1|P_bc_pls_factor" id="1678" />
-        <Map s="P_rbc_pls_factor" id="1679" />
-        <Map s="..|BP_AGP" id="1680" />
-        <Map s="Agp" id="1681" />
-        <Map s="..|BP_ALBUMIN" id="1682" />
-        <Map s="Albumin" id="1683" />
-        <Map s="..|Fraction unbound (plasma, reference value)" id="1684" />
-        <Map s="fu_ref" id="1685" />
-        <Map s="..|Plasma protein binding partner" id="1686" />
-        <Map s="BindingPartner" id="1687" />
-        <Map s="S1|Organism|Ontogeny factor (albumin)" id="1688" />
-        <Map s="AlbuminOntgenyFactor" id="1689" />
-        <Map s="S1|Organism|Ontogeny factor (alpha1-acid glycoprotein)" id="1690" />
-        <Map s="AgpOntogenyFactor" id="1691" />
-        <Map s="S1|Organism|Plasma protein scale factor" id="1692" />
-        <Map s="PlasmaProteinScaleFactor" id="1693" />
-        <Map s="LogP" id="1694" />
-        <Map s="..|Compound type 0" id="1695" />
-        <Map s="..|Compound type 1" id="1696" />
-        <Map s="..|CT_ACID" id="1697" />
-        <Map s="CT_ACID" id="1698" />
-        <Map s="..|pKa value 0" id="1699" />
-        <Map s="..|pKa value 1" id="1700" />
-        <Map s="..|pKa value 2" id="1701" />
-        <Map s="..|pKa_Acids_Count" id="1702" />
-        <Map s="pKa_Acids_Count" id="1703" />
-        <Map s="..|pKa_pH_WS_sol_F1" id="1704" />
-        <Map s="..|pKa_pH_WS_sol_F2" id="1705" />
-        <Map s="..|pKa_pH_WS_sol_F3" id="1706" />
-        <Map s="..|Is triprotic acid" id="1707" />
-        <Map s="IsTriproticAcid" id="1708" />
-        <Map s="..|pKa_Acid_0" id="1709" />
-        <Map s="pKa_Acid_0" id="1710" />
-        <Map s="..|pKa_Acid_2" id="1711" />
-        <Map s="pKa_Acid_2" id="1712" />
-        <Map s="..|Is triprotic base" id="1713" />
-        <Map s="IsTriproticBase" id="1714" />
-        <Map s="..|pKa_Base_0" id="1715" />
-        <Map s="pKa_Base_0" id="1716" />
-        <Map s="..|pKa_Base_2" id="1717" />
-        <Map s="pKa_Base_2" id="1718" />
-        <Map s="..|CT_BASE" id="1719" />
-        <Map s="CT_BASE" id="1720" />
-        <Map s="..|pKa_Bases_Count" id="1721" />
-        <Map s="pKa_Bases_Count" id="1722" />
-        <Map s="..|Compound type 2" id="1723" />
-        <Map s="..|pKa_pH_WS_sol_K1" id="1724" />
-        <Map s="..|pKa_pH_WS_sol_K2" id="1725" />
-        <Map s="..|pKa_pH_WS_sol_K3" id="1726" />
-        <Map s="..|pKa_pH_WS_sol_K4" id="1727" />
-        <Map s="..|pKa_pH_WS_sol_K5" id="1728" />
-        <Map s="..|pKa_pH_WS_sol_K6" id="1729" />
-        <Map s="..|pKa_pH_WS_sol_K7" id="1730" />
-        <Map s="..|pKa_pH_WS_sol_K8" id="1731" />
-        <Map s="..|Solubility gain per charge" id="1732" />
-        <Map s="..|pKa_ThreeBases_1" id="1733" />
-        <Map s="pKa_ThreeBases_1" id="1734" />
-        <Map s="..|pKa_TwoBases_1" id="1735" />
-        <Map s="pKa_TwoBases_1" id="1736" />
-        <Map s="CT_0" id="1737" />
-        <Map s="CT_1" id="1738" />
-        <Map s="CT_2" id="1739" />
-        <Map s="..|pKa_OneAcid_0" id="1740" />
-        <Map s="pKa_OneAcid_0" id="1741" />
-        <Map s="..|pKa_ThreeAcids_0" id="1742" />
-        <Map s="pKa_ThreeAcids_0" id="1743" />
-        <Map s="..|pKa_TwoAcids_0" id="1744" />
-        <Map s="pKa_TwoAcids_0" id="1745" />
-        <Map s="..|pKa_ThreeAcids_1" id="1746" />
-        <Map s="pKa_ThreeAcids_1" id="1747" />
-        <Map s="..|pKa_TwoAcids_1" id="1748" />
-        <Map s="pKa_TwoAcids_1" id="1749" />
-        <Map s="..|pKa_OneBase_0" id="1750" />
-        <Map s="pKa_OneBase_0" id="1751" />
-        <Map s="..|pKa_ThreeBases_0" id="1752" />
-        <Map s="pKa_ThreeBases_0" id="1753" />
-        <Map s="..|pKa_TwoBases_0" id="1754" />
-        <Map s="pKa_TwoBases_0" id="1755" />
-        <Map s="..|CT_NEUTRAL" id="1756" />
-        <Map s="..|Reference pH" id="1757" />
-        <Map s="..|Br" id="1758" />
-        <Map s="Br" id="1759" />
-        <Map s="..|Cl" id="1760" />
-        <Map s="Cl" id="1761" />
-        <Map s="..|F" id="1762" />
-        <Map s="F" id="1763" />
-        <Map s="..|I" id="1764" />
-        <Map s="I" id="1765" />
-        <Map s="..|Molecular weight" id="1766" />
-        <Map s="..|Effective molecular weight" id="1767" />
-        <Map s="MWEff" id="1768" />
-        <Map s="..|Is small molecule" id="1769" />
-        <Map s="IsSmallMolecule" id="1770" />
-        <Map s="..|Lipophilicity" id="1771" />
-        <Map s="Chlor" id="1772" />
-        <Map s="..|Tablet_Location" id="1773" />
-        <Map s="location" id="1774" />
-        <Map s="..|Tablet time delay factor" id="1775" />
-        <Map s="w_fact" id="1776" />
-        <Map s="..|Tablet_Location_cae" id="1777" />
-        <Map s="location_cae" id="1778" />
-        <Map s="..|Tablet_Location_colasc" id="1779" />
-        <Map s="location_colasc" id="1780" />
-        <Map s="..|Tablet_Location_coldesc" id="1781" />
-        <Map s="location_coldesc" id="1782" />
-        <Map s="..|Tablet_Location_colsigm" id="1783" />
-        <Map s="location_colsigm" id="1784" />
-        <Map s="..|Tablet_Location_coltrans" id="1785" />
-        <Map s="location_coltrans" id="1786" />
-        <Map s="..|Tablet_Location_duo" id="1787" />
-        <Map s="location_duo" id="1788" />
-        <Map s="..|Tablet_Location_lil" id="1789" />
-        <Map s="location_lil" id="1790" />
-        <Map s="..|Tablet_Location_lje" id="1791" />
-        <Map s="location_lje" id="1792" />
-        <Map s="..|Tablet_Location_rect" id="1793" />
-        <Map s="location_rect" id="1794" />
-        <Map s="..|Tablet_Location_sto" id="1795" />
-        <Map s="location_sto" id="1796" />
-        <Map s="..|Tablet_Location_uil" id="1797" />
-        <Map s="location_uil" id="1798" />
-        <Map s="..|Tablet_Location_uje" id="1799" />
-        <Map s="location_uje" id="1800" />
-        <Map s="..|TabletIsActive" id="1801" />
-        <Map s="TabletIsActive" id="1802" />
-        <Map s="..|ProtocolSchemaItem|Start time" id="1803" />
-        <Map s="S1|Organism|Lumen|Stomach|GET of non-disintegrated moiety" id="1804" />
-        <Map s="LagTime" id="1805" />
-        <Map s="w_sto" id="1806" />
-        <Map s="FillLevelFlag_duo" id="1807" />
-        <Map s="w_duo" id="1808" />
-        <Map s="FillLevelFlag_uje" id="1809" />
-        <Map s="w_uje" id="1810" />
-        <Map s="FillLevelFlag_lje" id="1811" />
-        <Map s="w_lje" id="1812" />
-        <Map s="FillLevelFlag_uil" id="1813" />
-        <Map s="w_uil" id="1814" />
-        <Map s="FillLevelFlag_lil" id="1815" />
-        <Map s="w_lil" id="1816" />
-        <Map s="FillLevelFlag_cae" id="1817" />
-        <Map s="w_cae" id="1818" />
-        <Map s="FillLevelFlag_colasc" id="1819" />
-        <Map s="w_colasc" id="1820" />
-        <Map s="FillLevelFlag_coltrans" id="1821" />
-        <Map s="w_coltrans" id="1822" />
-        <Map s="FillLevelFlag_coldesc" id="1823" />
-        <Map s="w_coldesc" id="1824" />
-        <Map s="FillLevelFlag_colsigm" id="1825" />
-        <Map s="w_colsigm" id="1826" />
-        <Map s="FillLevelFlag_rect" id="1827" />
-        <Map s="w_rect" id="1828" />
-        <Map s="..|..|ProtocolSchemaItem|DrugMass" id="1829" />
-        <Map s="DrugMass" id="1830" />
-        <Map s="..|..|ProtocolSchemaItem|Amount of water" id="1831" />
-        <Map s="Water" id="1832" />
-        <Map s="Tablet_Location" id="1833" />
-        <Map s="..|Dose" id="1834" />
-        <Map s="Dose" id="1835" />
-        <Map s="..|DosePerBodyWeight" id="1836" />
-        <Map s="DosePerBodyWeight" id="1837" />
-        <Map s="Dose per body weight" id="1838" />
-        <Map s="..|Volume of water/body weight" id="1839" />
-        <Map s="AmountOfWaterPerBodyWeight" id="1840" />
-        <Map s="Volume per body weight" id="1841" />
-        <Map s="..|C1" id="1842" />
-        <Map s="BinDrugMassSolid" id="1843" />
-        <Map s="..|InsolubleDrug|C1" id="1844" />
-        <Map s="BinDrugMassInsoluble" id="1845" />
-        <Map s="..|DrugMass of particle bin" id="1846" />
-        <Map s="BinDrugMass" id="1847" />
-        <Map s="..|Fraction insoluble" id="1848" />
-        <Map s="FractionInsoluble" id="1849" />
-        <Map s="..|Fraction solid" id="1850" />
-        <Map s="FractionSolid" id="1851" />
-        <Map s="..|Number of particles" id="1852" />
-        <Map s="N" id="1853" />
-        <Map s="..|Particle radius (at t=0)" id="1854" />
-        <Map s="r0" id="1855" />
-        <Map s="S1|C1|Density (drug)" id="1856" />
-        <Map s="DrugDensity" id="1857" />
-        <Map s="..|Number_Of_Particles_Factor" id="1858" />
-        <Map s="Number_Of_Particles_Factor" id="1859" />
-        <Map s="Inversed volume" id="1860" />
-        <Map s="..|..|..|Tablet_Location_cae" id="1861" />
-        <Map s="Tablet_Location_cae" id="1862" />
-        <Map s="..|..|..|Tablet_Location_colasc" id="1863" />
-        <Map s="Tablet_Location_colasc" id="1864" />
-        <Map s="..|..|..|Tablet_Location_coldesc" id="1865" />
-        <Map s="Tablet_Location_coldesc" id="1866" />
-        <Map s="..|..|..|Tablet_Location_colsigm" id="1867" />
-        <Map s="Tablet_Location_colsigm" id="1868" />
-        <Map s="..|..|..|Tablet_Location_coltrans" id="1869" />
-        <Map s="Tablet_Location_coltrans" id="1870" />
-        <Map s="..|..|..|Tablet_Location_duo" id="1871" />
-        <Map s="Tablet_Location_duo" id="1872" />
-        <Map s="..|..|..|Tablet_Location_lil" id="1873" />
-        <Map s="Tablet_Location_lil" id="1874" />
-        <Map s="..|..|..|Tablet_Location_lje" id="1875" />
-        <Map s="Tablet_Location_lje" id="1876" />
-        <Map s="..|..|..|Tablet_Location_rect" id="1877" />
-        <Map s="Tablet_Location_rect" id="1878" />
-        <Map s="..|..|..|Tablet_Location_sto" id="1879" />
-        <Map s="Tablet_Location_sto" id="1880" />
-        <Map s="..|..|..|Tablet_Location_uil" id="1881" />
-        <Map s="Tablet_Location_uil" id="1882" />
-        <Map s="..|..|..|Tablet_Location_uje" id="1883" />
-        <Map s="Tablet_Location_uje" id="1884" />
-        <Map s="rho" id="1885" />
-        <Map s="S1|C1|Immediately dissolve particles smaller than" id="1886" />
-        <Map s="ParticleRadiusDissolved" id="1887" />
-        <Map s="..|..|..|..|DrugMass of particle bin" id="1888" />
-        <Map s="X0" id="1889" />
-        <Map s="..|..|..|..|Particle radius (at t=0)" id="1890" />
-        <Map s="..|..|..|..|..|..|Thickness (unstirred water layer)" id="1891" />
-        <Map s="h" id="1892" />
-        <Map s="S1|C1|Aqueous diffusion coefficient" id="1893" />
-        <Map s="D" id="1894" />
-        <Map s="Diffusion coefficient" id="1895" />
-        <Map s="..|..|..|..|C1" id="1896" />
-        <Map s="X" id="1897" />
-        <Map s="S" id="1898" />
-        <Map s="S1|C1|Treat precipitated drug as" id="1899" />
-        <Map s="PrecipitatedDrugSoluble" id="1900" />
-        <Map s="..|..|..|..|Tablet_Location_cae" id="1901" />
-        <Map s="..|..|..|..|TabletIsActive" id="1902" />
-        <Map s="Precipitation rate of the tablet" id="1903" />
-        <Map s="ParticlesPrecipitationRate" id="1904" />
-        <Map s="..|..|..|..|Tablet_Location_colasc" id="1905" />
-        <Map s="..|..|..|..|Tablet_Location_coldesc" id="1906" />
-        <Map s="..|..|..|..|Tablet_Location_colsigm" id="1907" />
-        <Map s="..|..|..|..|Tablet_Location_coltrans" id="1908" />
-        <Map s="..|..|..|..|Tablet_Location_duo" id="1909" />
-        <Map s="..|..|..|..|Tablet_Location_lil" id="1910" />
-        <Map s="..|..|..|..|Tablet_Location_lje" id="1911" />
-        <Map s="..|..|..|..|Tablet_Location_rect" id="1912" />
-        <Map s="S1|Organism|Lumen|Stomach|C1|Solubility" id="1913" />
-        <Map s="..|..|..|..|Tablet_Location_sto" id="1914" />
-        <Map s="..|..|..|..|Tablet_Location_uil" id="1915" />
-        <Map s="..|..|..|..|Tablet_Location_uje" id="1916" />
-        <Map s="..|..|..|DrugMass of particle bin" id="1917" />
-        <Map s="..|..|..|Particle radius (at t=0)" id="1918" />
-        <Map s="..|..|..|..|..|Thickness (unstirred water layer)" id="1919" />
-        <Map s="..|.." id="1920" />
-        <Map s="..|..|..|TabletIsActive" id="1921" />
-        <Map s="Release rate of the tablet" id="1922" />
-        <Map s="TabletReleaseRate" id="1923" />
-        <Map s="ParticleBinDrugMass" id="1924" />
-        <Map s="S1|Applications|Particles|Application_1|ProtocolSchemaItem|DrugMass" id="1925" />
-        <Map s="M_1" id="1926" />
-      </StringMap>
-    </FormulaCache>
-  </Model>
-</MoBiSimulation>
\ No newline at end of file
diff --git a/tests/MoBi.Tests/TestFiles/ModelCoreSimulation3_0.pkml b/tests/MoBi.Tests/TestFiles/ModelCoreSimulation3_0.pkml
deleted file mode 100644
index 49d602c8f..000000000
--- a/tests/MoBi.Tests/TestFiles/ModelCoreSimulation3_0.pkml
+++ /dev/null
@@ -1,47375 +0,0 @@
-<?xml version="1.0" encoding="utf-8"?>
-<ModelCoreSimulation id="IJJv3kA_CUu03DiwXf9kIg" name="T1">
-  <BuildConfiguration>
-    <Molecules id="6JwkEM4jyU-TXuP0XM1WzQ" name="T1">
-      <Builders>
-        <MoleculeBuilder id="wHEYooS4z0u_6x-QKyspVg" name="Drug" icon="Drug" mode="Logical" containerType="Other" isFloating="1" quantityType="Drug" defaultStartFormula="aqBwpXZN_0KsbmO30G0sjg">
-          <Children>
-            <Parameter id="0HJZZ51OiEy2yBvtHkaAwg" name="pKa_Acid_2" description="Largest acid pKa" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_Acid_2" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="oWYlgoFR5EO_-RZpsifdrg" name="pKa_pH_WS_sol_K1" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_K1" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="8JUJ92spxkeiq3ITGjfBCA" name="Is triprotic base" description="Is triprotic base" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_IsTriproticBase" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="K4l1ts32U0exMX_l6B5u-Q" name="Molecular weight" description="Molecular weight" persistable="0" isFixedValue="0" formula="rBI1eaMaOECu1Ncq4ZB7hw" dim="MolecularWeight" quantityType="0" buildMode="Property" />
-            <Parameter id="_IMusuH_Tkag2DLcGFFzrw" name="pKa value 0" description="pKa value" persistable="0" isFixedValue="0" formula="Ec8Ve1hf10C3ioY5R_PjMA" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="ginUAfGtvU22Wd9PmlR1pg" name="pKa value 1" description="pKa value" persistable="0" isFixedValue="0" formula="CaINSfHRwUmn26YMqJpmJQ" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="1J9b7K3xX0qd6p3FmRamZg" name="pKa value 2" description="pKa value" persistable="0" isFixedValue="0" formula="Y2xBY54IUEmVvLgA27LBuQ" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="bmgJ5hVmoU6tH6P8vbBMPQ" name="Is strong base" description="Supporting parameter for partition coeffs in RR-Modell (at least one basic pKa&gt;=7)" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_HasStrongBase" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="GjZd0ZC-4UGUHNF48Ndj0w" name="pKa_Acid_1" description="Middle acid pKa" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_Acid_1" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="fHoNfkVasUiqLdwrQaSXvA" name="Is small molecule" description="Treat compound as small molecule or not (if not, both organ specific and intestinal permeability will be set to zero)" persistable="0" isFixedValue="0" formula="Wc1mqeP_6EKVQ2PvCA-qBw" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="dOoguWRUv0SNpk8f2HMV-g" name="pKa_Acids_Count" description="Number of acidic groups in compound" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_Acids_Count" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="zZLTR1v5Z0abdA5pg3o1CQ" name="pKa_Base_0" description="Smallest base pKa" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_Base_0" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="EUr_d67InkSD8DSi_m0RSQ" name="pKa_Base_1" description="Middle base pKa" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_Base_1" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="T1sLZ6pt8kCsNe06MKL-Xw" name="pKa_Base_2" description="Largest base pKa" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_Base_2" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="2MAN0H9WA0i5uzemqHBZJg" name="pKa_Bases_Count" description="Number of basic groups in compound" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_Bases_Count" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="FmICVSrMf0me1OM3XPa4GA" name="pKa_OneAcid_0" description="Smallest acid pKa for compound with 1 acid group" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_OneAcid_0" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="NRz1g9DeokicfvsvDJMINw" name="pKa_OneBase_0" description="Smallest base pKa for compound with 1 base group" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_OneBase_0" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="gcgNOxe7okyJcG7LcilWdw" name="pKa_pH_WS_sol_F1" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_F1" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="u9UdW-BiJ0WHGiZhPvItUw" name="pKa_pH_WS_sol_F2" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_F2" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="vO-RMmjYskid-wDtscbWPw" name="pKa_Acid_0" description="Smallest acid pKa" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_Acid_0" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="5vP0xgtFJ0KiFkD3iOK4hg" name="I" description="Number of iodine atoms in molecule" persistable="0" isFixedValue="0" formula="F1XVoTRk50GtVHVn3IiFyg" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="_iCxdznmeUODWtz2M_4gYQ" name="Compound type 1" description="Compound type (-1: acid, +1: base, 0: neutral)" persistable="0" isFixedValue="0" formula="omKYv_6MNUOanwYY3G_-Aw" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="5gbfNbL8hUudfkuY2El7OQ" name="Compound type 2" description="Compound type (-1: acid, +1: base, 0: neutral)" persistable="0" isFixedValue="0" formula="YEPBPO4UU0mj36Wg0q4LKg" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="yFhqx5iQb0yVfDqo-i821Q" name="CT_ACID" description="Constant for compound type acid" persistable="0" isFixedValue="0" formula="4ucIU-OIA0eeLtMESEDjkQ" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="IB3ivVlYZU-x7VcbGk5hgw" name="CT_BASE" description="Constant for compound type base" persistable="0" isFixedValue="0" formula="uzCMYE7MtU6ob7jySb3E4Q" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="BgeOcwkJGUm9Ba4XlJsaVw" name="CT_NEUTRAL" description="Constant for compound type neutral" persistable="0" isFixedValue="0" formula="MtLydXgmwU2r3KdsucmGRQ" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="TKzj1TAS6kyU7YzWtWxPNw" name="Effective molecular weight" description="Effective molecular weight" persistable="0" isFixedValue="0" formula="CompoundMW_PKSim.PARAM_MWEff" dim="MolecularWeight" quantityType="0" buildMode="Property" />
-            <Parameter id="4v9dV0S-0U6ypKKzjH47dg" name="F" description="Number of fluorine atoms in molecule" persistable="0" isFixedValue="0" formula="T7znnychRE-5Lyp2H3WIxg" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="Q01jF-USDkG31zAMUvWPdQ" name="Is triprotic acid" description="Is triprotic acid" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_IsTriproticAcid" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="CuFRBz5B8Ei2sr41j0EXfg" name="Has halogens" description="Supporting parameter for compound" persistable="0" isFixedValue="0" formula="CompoundMW_PKSim.PARAM_HasHalogens" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="dQa7Ai-tvUyCrm2Gj4sG3w" name="pKa_pH_WS_sol_K2" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_K2" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="HqA5iMrjC0SmPIaBHdhtfQ" name="Is diprotic acid" description="Is diprotic acid" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_IsDiproticAcid" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="33qgINt0LU2-7UOt3Clt1g" name="Is diprotic base" description="Is diprotic base" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_IsDiproticBase" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="MZ2Do-XdiU2bl83B-QW-Sw" name="Is diprotic base monoprotic acid" description="Is diprotic base monoprotic acid" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_IsDiproticBaseMonoproticAcid" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="Xyq5UB0zwEuZW2OD58yf3w" name="Is floating in lumen" description="Is floating in lumen" persistable="0" isFixedValue="0" formula="TpGu2JtAOUqTE4Yni1CwIg" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="j7nwwgFJYEOJCr7RXVpNKA" name="Is monoprotic acid" description="Is monoprotic acid" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_IsMonoproticAcid" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="dGqJ92vONEK5tqxzWZGI7g" name="Is monoprotic base" description="Is monoprotic base" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_IsMonoproticBase" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="S9mCGx5710a1W-Fst2sBXA" name="Is monoprotic base diprotic acid" description="Is monoprotic base diprotic acid" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_IsMonoproticBaseDiproticAcid" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="wn3ePkin6kGpIXExPk74JQ" name="Is monoprotic base monoprotic acid" description="Is monoprotic base monoprotic acid" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_IsMonoproticBaseMonoproticAcid" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="GjBLNC4p6ECzK-G18Q8Ztg" name="Is neutral" description="Supporting parameter for partition coeffs in RR-Modell" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_IsNeutral" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="fG5MwhGxb0SgfsAkD929UA" name="pKa_pH_WS_sol_F3" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_F3" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="xJ46Oe8Xnk2QrWLpnkkf2A" name="pKa_TwoAcids_1" description="Middle acid pKa for compound with 2 acid groups" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_TwoAcids_1" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="5aVvDChupEqBzc_IGcZ4kQ" name="pKa_pH_WS_sol_K3" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_K3" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="l0hnPEtm7E2Mg6EfKDymRg" name="pKa_pH_WS_sol_K4" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_K4" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="VnqOHERYjkauHGVjVKtAGA" name="pKa_pH_WS_sol_K5" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_K5" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="maeXqhS8dkyfyTn4uOQjpQ" name="pKa_pH_WS_sol_K6" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_K6" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="IxzWkxQsK0W38uDLnX3S5A" name="pKa_pH_WS_sol_K7" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_K7" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="sh61BDQyqkevbTJbEVGLjw" name="pKa_pH_WS_sol_K8" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_K8" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="9Nx_35PYoU6yYrtd39HJcQ" name="pKa_ThreeAcids_0" description="Smallest acid pKa for compound with 3 acid groups" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_ThreeAcids_0" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="1wurg_r9CUKW-RIH2XMnmg" name="pKa_ThreeAcids_1" description="Middle acid pKa for compound with 3 acid groups" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_ThreeAcids_1" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="0U6vm_eJu0avqs9WPEFJDg" name="pKa_ThreeBases_0" description="Smallest base pKa for compound with 3 base groups" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_ThreeBases_0" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="U2D-sqfQ1UeflxcMxwXoYA" name="pKa_TwoAcids_0" description="Smallest acid pKa for compound with 2 acid groups" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_TwoAcids_0" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="nv9hSvGVCE-6aj39GAdFcQ" name="pKa_TwoBases_0" description="Smallest base pKa for compound with 2 base groups" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_TwoBases_0" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="SkGXzgzLhUK1qIuxhMhg6g" name="pKa_TwoBases_1" description="Middle base pKa for compound with 2 base groups" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_TwoBases_1" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="aqnRTkt64Eq1kfLhylPedA" name="Solubility gain per charge" description="Supporting parameter for calculation of pKa- and pH- dependent values of intestinal solubilty" persistable="0" isFixedValue="0" formula="39qWs34RSk6H__xVJgJYZQ" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="3wZkGPP960SYp1Q_8lfO2A" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_RefpH_Factor" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="9GaGcpVti0Sr5ikd4crAiA" name="Total oral drug mass" description="Total oral drug mass" persistable="0" isFixedValue="0" formula="r6RCH_D26kSvFRHyoEV7QA" dim="Amount" quantityType="0" buildMode="Property" />
-            <Parameter id="AXpc7lDUDk2utmmyKL3lpA" name="pKa_ThreeBases_1" description="Middle base pKa for compound with 3 base groups" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_ThreeBases_1" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="P8YWWiNs7kOh61BIR1Im9g" name="Cl" description="Number of chlorine atoms in molecule" persistable="0" isFixedValue="0" formula="vN2LMVfm0kq95bEkkujMdw" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="wI_ud-R3VUuZXUssNmcO2g" name="Br" description="Number of bromine atoms in molecule" persistable="0" isFixedValue="0" formula="NlU0xA3QPEODngmqKQcMjg" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="Vk3aZIQqAkaiVOr8hljkyQ" name="Compound type 0" description="Compound type (-1: acid, +1: base, 0: neutral)" persistable="0" isFixedValue="0" formula="W77bFDXprk--9rIpnz6j3w" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="Q8Iay2nt0UyQrhhNIFTY6Q" name="base_For_KaPL_Factor" description="Supporting parameter for calculation of pKa- and pH- dependent values of KaPL" persistable="0" isFixedValue="0" formula="xt5auC5C10Gk8WznytiUIA" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="gYHWk8RwKE-xMnNgmiIyLA" name="base_For_logD_Factor" description="Supporting parameter for calculation of pKa- and pH- dependent logD" persistable="0" isFixedValue="0" formula="dM8u_cjxG0iYSAAr5ZOWrg" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="NQ4xbjh3FkOIm_hwmER8uQ" name="base_For_P_cell_Factor" description="Supporting parameter for calculation of pKa- and pH- dependent permeability to/from cells" persistable="0" isFixedValue="0" formula="dpxXSMbTkUum8jXIc0F70A" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="rAx6x5WlyUqeke0SQhWplA" name="base_For_Pint_Factor" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="U11W8yIUpUuEgh3yV7vuCA" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="sQHb-Yn7AkyV2mnssh0SlA" name="Lipophilicity" description="Model dependent lipophilicity measure: LogMA / LogP / ..." persistable="0" isFixedValue="0" formula="JLvkwXryp06oPp5KL5ew9w" dim="Lipophilicity" quantityType="0" buildMode="Property" />
-            <Parameter id="FrPOkD-oN0eLOORi9LIMcA" name="Fraction unbound (plasma)" description="Fraction unbound in plasma" persistable="0" isFixedValue="0" formula="yFmgBNO9n0i5dw3LwKDbBQ" dim="Fraction" quantityType="0" buildMode="Property" />
-            <Parameter id="Nn7ZpaMRqUaL2TF77gJJkA" name="Solubility at reference pH" description="Solubility at reference pH" persistable="0" isFixedValue="0" formula="fs7LHl3osEKCWcs9jRkO0w" dim="Concentration" quantityType="0" buildMode="Property" />
-            <Parameter id="3aj_g5qMHUqGJVya9AxsyQ" name="Reference pH" description="Reference pH" persistable="0" isFixedValue="0" formula="1CKaI9w3AkK5CxRsA1TqoA" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="W79y2dp1SkutUiSHahqWdw" name="Permeability" description="Permeability" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_P" dim="Velocity" quantityType="0" buildMode="Property" />
-            <Parameter id="r_-M3981PkOwYJf2SwFlBg" name="Specific intestinal permeability (transcellular)" description="Specific intestinal permeability (transcellular)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_InVitro" dim="Velocity" quantityType="0" buildMode="Property" />
-            <Parameter id="dMLzSs0AIEWDZWJdVBrzLQ" name="Partition coefficient (water/protein)" description="Partition coefficient water to protein" persistable="0" isFixedValue="0" formula="DistributionInVitro_PKSim.PARAM_KProt" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="9gUOYunfqkeXKKKuB0up7w" name="Treat precipitated drug as" description="Treat precipitated drug as either soluble or insoluble" persistable="0" isFixedValue="0" formula="das5TTr4SEi8utp_LML_tw" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="ldirdvgqRkacrvMBwUtMaQ" name="Aqueous diffusion coefficient" description="Aqueous diffusion coefficient&#xA;of the drug" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_Aqueous_diffusion_coefficient" dim="DiffusionCoefficient" quantityType="0" buildMode="Property" />
-            <Parameter id="EwTpW77mC0qBP4maEDQxmw" name="Density (drug)" description="Density of drug material" persistable="0" isFixedValue="0" formula="YcvsqVCdB0C7OSjx9p7Hhg" dim="Density" quantityType="0" buildMode="Property" />
-            <Parameter id="jnjqOxjcLUOzfR-9dUZrng" name="Immediately dissolve particles smaller than" description="Threshold for the particle radius of immediate dissolution" persistable="0" isFixedValue="0" formula="l_dREQPki06PiqdnGGomDA" dim="Nanolength" quantityType="0" buildMode="Property" />
-            <Parameter id="4WVdziJHKUi8kxFYxq_z4Q" name="Radius (solute)" description="Solute radius" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_Ae" dim="Nanolength" quantityType="0" buildMode="Property" />
-            <Parameter id="A01VLmMA9UW1WO6aBVaPeQ" name="Kd (FcRn)" description="Dissociation constant for binding of drug to FcRn" persistable="0" isFixedValue="0" formula="5SiFtDkBl0ScQFEgMC2wvg" dim="MolarConcentration" quantityType="0" buildMode="Property" />
-            <Parameter id="bsh7bst4WEemVQiLnlvYuw" name="Use pH- and pKa-dependent penalty factor for charged molecule fraction" description="Penalty factor for charged molecule fraction is used for &quot;Intestinal permeability (transcellular)&quot; only" persistable="0" isFixedValue="0" formula="SLgIn2riak6ti9LXWbkPOw" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="bIwyf-1Z7EqrDP-oY1xSsg" name="Concentration" persistable="0" isFixedValue="0" formula="ConcFormula" dim="MolarConcentration" quantityType="0" />
-          </Children>
-          <UsedCalculationMethods>
-            <UsedCalculationMethod category="DistributionCellular" calculationMethod="Cellular partition coefficient method - PK-Sim Standard" />
-            <UsedCalculationMethod category="DiffusionIntCell" calculationMethod="Cellular permeability - PK-Sim Standard" />
-            <UsedCalculationMethod category="DistributionInterstitial" calculationMethod="Interstitial partition coefficient method - Schmitt" />
-          </UsedCalculationMethods>
-        </MoleculeBuilder>
-        <MoleculeBuilder id="llvbJtjat0abo-WSYdvz_Q" name="Cyp" icon="Enzyme" mode="Logical" containerType="Other" isFloating="0" quantityType="Enzyme" defaultStartFormula="CompoundCommon.STARTAMOUNT_Protein">
-          <Children>
-            <Parameter id="GtTdrbA2A0ijyve-NRzD6A" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" formula="qtkLrA9XkUaqau0uwIXXnQ" dim="Dimensionless" quantityType="0" />
-            <Parameter id="2tOkh6ffqkCZrC_nURA5Ag" name="Relative expression in plasma (normalized)" description="Relative expression norm in plasma" persistable="0" isFixedValue="0" formula="7F3SxkuynE2fHZNCn98NqQ" dim="Fraction" quantityType="0" buildMode="Global" />
-            <Parameter id="sxs8Iw33_E-CymPqYOg3cw" name="Relative expression out." description="Relative Expression that will be used in the simulation" persistable="0" isFixedValue="0" formula="RkWer8pqGE2smn6AFwsnuw" dim="Fraction" quantityType="0" />
-            <Parameter id="pBewmzccT0O3kZE4oHWYHw" name="Relative expression in vascular endothelium" description="Relative expression in vasc. Endothelium" persistable="0" isFixedValue="0" formula="dwiqqm7OoEqu8h9RrYbt6Q" dim="Fraction" quantityType="0" buildMode="Global" />
-            <Parameter id="tyUjBNrk1k-RYXLqT3ccVQ" name="Relative expression in plasma" description="Relative expression in plasma" persistable="0" isFixedValue="0" formula="I4saaf0Z-EW2o8WnU1rm1A" dim="Fraction" quantityType="0" buildMode="Global" />
-            <Parameter id="bHXdX-ZbgkCkWVBTP8rITg" name="Relative expression in blood cells" description="Relative expression in blood cells" persistable="0" isFixedValue="0" formula="0QE5O1EaG0GgAtu2h4--sQ" dim="Fraction" quantityType="0" buildMode="Global" />
-            <Parameter id="TM6mcrU7B0SeL3oLpEOQ8A" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" persistable="0" isFixedValue="0" formula="BO0ulxyFTkydolRsa7k7IA" dim="Fraction" quantityType="0" />
-            <Parameter id="XVFDtqaX_0-2H5Q1LkdILQ" name="Relative expression" description="Relative expression" persistable="0" isFixedValue="0" formula="3fc_VsCcy0SITgdlXh18hw" dim="Fraction" quantityType="0" />
-            <Parameter id="pi8nSD0XeECUBlMI7XQ5ig" name="Rel. exp. variability factor" description="Variability factor for relative expressions" persistable="0" isFixedValue="0" formula="oMOJ5Jrptk6CrbeIf9RrUw" dim="Dimensionless" quantityType="0" buildMode="Global" />
-            <Parameter id="7Mz0UgB3HUWnx9zVVYMXIA" name="Reference concentration" description="Reference concentration" persistable="0" isFixedValue="0" formula="TtTKJpymqku03s8t0zMflQ" dim="MolarConcentration" quantityType="0" buildMode="Global" />
-            <Parameter id="sCVaWzywz0WHhvxg0bX5xg" name="Relative expression in vascular endothelium (normalized)" description="Relative expression in vasc. Endothelium" persistable="0" isFixedValue="0" formula="IobAQXFfY0e-vMk27h95kg" dim="Fraction" quantityType="0" buildMode="Global" />
-            <Parameter id="NOWMhzSgck28RYDfDgQleQ" name="Relative expression in blood cells (normalized)" description="Relative expression norm in blood cells" persistable="0" isFixedValue="0" formula="kwIvO439A0G2211Xzwl2fQ" dim="Fraction" quantityType="0" buildMode="Global" />
-            <Parameter id="H__jd5txqUOONtQ9mgeYwQ" name="pKa_Acid_2" description="Largest acid pKa" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_Acid_2" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="9BTA_F8Nr0ePpi4m4Va_6w" name="pKa_pH_WS_sol_K1" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_K1" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="NDECwo5UaEqLT1gF-smiMw" name="Is triprotic base" description="Is triprotic base" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_IsTriproticBase" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="0bwYEY740kOcPeclPegQbg" name="Molecular weight" description="Molecular weight" persistable="0" isFixedValue="0" formula="JZYl1MxAHkCpAFdoLOeY9g" dim="MolecularWeight" quantityType="0" buildMode="Property" />
-            <Parameter id="wLX47vDq9EOl5KfPM9n3OA" name="pKa value 0" description="pKa value" persistable="0" isFixedValue="0" formula="1J8vm7jJEEOWFf01HBiLOA" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="QdS84wWQdkOIEGxZaF5j0g" name="pKa value 1" description="pKa value" persistable="0" isFixedValue="0" formula="oLVIfnPbiUiQ8d_mtEZCFA" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="v6hAhDGD3kGxSYcCh4S3Jg" name="pKa value 2" description="pKa value" persistable="0" isFixedValue="0" formula="NP18mY51KkSlZUj_aiybVQ" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="wkLUkwTbk0qzHsTvRsUtVA" name="Is strong base" description="Supporting parameter for partition coeffs in RR-Modell (at least one basic pKa&gt;=7)" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_HasStrongBase" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="Qggg_iixSUCuCZgbJdzjvQ" name="pKa_Acid_1" description="Middle acid pKa" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_Acid_1" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="4Ewf-yLcREyFGRtefrNnEg" name="Is small molecule" description="Treat compound as small molecule or not (if not, both organ specific and intestinal permeability will be set to zero)" persistable="0" isFixedValue="0" formula="8xSl-euTp02lbh1wmCZarg" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="aIvflG1_3km1xh1PSXlMAA" name="pKa_Acids_Count" description="Number of acidic groups in compound" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_Acids_Count" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="Z8qg8bvo8kK2N9BsPRmAug" name="pKa_Base_0" description="Smallest base pKa" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_Base_0" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="JRc8e0cU6E2OeRmfVsyEbA" name="pKa_Base_1" description="Middle base pKa" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_Base_1" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="d8mO2YJpEkqtL-56MmH3kg" name="pKa_Base_2" description="Largest base pKa" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_Base_2" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="cAIdXqyUJkuJT394ZB339Q" name="pKa_Bases_Count" description="Number of basic groups in compound" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_Bases_Count" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="6TqURIfYD0Cvh1_wWAaYMQ" name="pKa_OneAcid_0" description="Smallest acid pKa for compound with 1 acid group" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_OneAcid_0" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="B5pXDu9P8kytuGtFpY07ug" name="pKa_OneBase_0" description="Smallest base pKa for compound with 1 base group" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_OneBase_0" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="FabVqI1AvUKPDDOj_ttKFw" name="pKa_pH_WS_sol_F1" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_F1" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="Nd_jXNe7BU6eLFgbxYTeIw" name="pKa_pH_WS_sol_F2" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_F2" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="faz8smfoo0-1WwOQiCu2tQ" name="pKa_Acid_0" description="Smallest acid pKa" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_Acid_0" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="Xo6dg591I0Gw0cBsq75dbg" name="I" description="Number of iodine atoms in molecule" persistable="0" isFixedValue="0" formula="NJclQnwSvUmPoFvhv7fSdg" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="a2bSzen6NE6njUvBt58qpw" name="Compound type 1" description="Compound type (-1: acid, +1: base, 0: neutral)" persistable="0" isFixedValue="0" formula="qAKxZA5hr0y-U-3x418IsA" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="fJeGZlQvzky16m2mv1RaXw" name="Compound type 2" description="Compound type (-1: acid, +1: base, 0: neutral)" persistable="0" isFixedValue="0" formula="JnRYoSPHcU-5FawbO05MKg" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="R3ZR_KDaRE-IaL7is2KFdQ" name="CT_ACID" description="Constant for compound type acid" persistable="0" isFixedValue="0" formula="VWFmEe0AL0yqLftfs0vZ4A" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="Pty7xU45BkKK901GeqByyQ" name="CT_BASE" description="Constant for compound type base" persistable="0" isFixedValue="0" formula="D-cWcUjn5k25fTHcob9wxQ" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="uJMi7nC91k-ZagovfRxCNw" name="CT_NEUTRAL" description="Constant for compound type neutral" persistable="0" isFixedValue="0" formula="52_QPEVbNkCFCFqiHF687Q" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="8F_GLoj6tUmgLzi5rTxvSA" name="Effective molecular weight" description="Effective molecular weight" persistable="0" isFixedValue="0" formula="CompoundMW_PKSim.PARAM_MWEff" dim="MolecularWeight" quantityType="0" buildMode="Property" />
-            <Parameter id="Lku1vEa-LEuClwHowQ3Z2w" name="F" description="Number of fluorine atoms in molecule" persistable="0" isFixedValue="0" formula="wxPFOzTR7E68g7Q5_yxQuQ" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="FjgCFi1K2UKzYFuJRSpCRA" name="Is triprotic acid" description="Is triprotic acid" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_IsTriproticAcid" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="2xc_ZJfR_UWHPS35e-sbQw" name="Has halogens" description="Supporting parameter for compound" persistable="0" isFixedValue="0" formula="CompoundMW_PKSim.PARAM_HasHalogens" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="6bq29F1NdUatAAFpYM5xSg" name="pKa_pH_WS_sol_K2" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_K2" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="Lgg_UzbrfUy27q0FbclcjA" name="Is diprotic acid" description="Is diprotic acid" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_IsDiproticAcid" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="E43Zjx7oo0WtIBFfrUSPkw" name="Is diprotic base" description="Is diprotic base" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_IsDiproticBase" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="MB64x8d1iU-a6I9IINtKKw" name="Is diprotic base monoprotic acid" description="Is diprotic base monoprotic acid" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_IsDiproticBaseMonoproticAcid" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="AyNNI0MAhkWrSx_J59iBkg" name="Is floating in lumen" description="Is floating in lumen" persistable="0" isFixedValue="0" formula="NTvAhGq56kafne4uynWH4Q" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="tYjFZD3qYkqK6umAtv3hBg" name="Is monoprotic acid" description="Is monoprotic acid" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_IsMonoproticAcid" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="GCJFi9HfqE-nmGdBQJTrEg" name="Is monoprotic base" description="Is monoprotic base" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_IsMonoproticBase" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="VeIaLGzWrEOx9l9kLIFOqA" name="Is monoprotic base diprotic acid" description="Is monoprotic base diprotic acid" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_IsMonoproticBaseDiproticAcid" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="kj7aYNz70kSEEs8z_p2HfQ" name="Is monoprotic base monoprotic acid" description="Is monoprotic base monoprotic acid" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_IsMonoproticBaseMonoproticAcid" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="CMkPXoodO06WPe0A-_VHOw" name="Is neutral" description="Supporting parameter for partition coeffs in RR-Modell" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_IsNeutral" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="uPSYLlUNQU2TyH2EXGWpzg" name="pKa_pH_WS_sol_F3" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_F3" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="TeLZNCeGZ0Wwm-aibqmYOQ" name="pKa_TwoAcids_1" description="Middle acid pKa for compound with 2 acid groups" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_TwoAcids_1" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="ghFACXZd10OaF4rS1bDKWQ" name="pKa_pH_WS_sol_K3" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_K3" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="erycn5q4b0CJS23Zrr2W1w" name="pKa_pH_WS_sol_K4" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_K4" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="gMZZxm5cHkaaC6m5s7FVUg" name="pKa_pH_WS_sol_K5" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_K5" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="iK9rNy5ahkCxjx_6r6_HEQ" name="pKa_pH_WS_sol_K6" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_K6" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="b-QiRM8NxEO3UFf10ALKjg" name="pKa_pH_WS_sol_K7" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_K7" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="jmmDqhKbjUejvlpLyrLF8g" name="pKa_pH_WS_sol_K8" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_K8" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="2EDYdQadsUmzY_zoRNnG1g" name="pKa_ThreeAcids_0" description="Smallest acid pKa for compound with 3 acid groups" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_ThreeAcids_0" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="L3N2hW11xEC-MAlF0gpuTg" name="pKa_ThreeAcids_1" description="Middle acid pKa for compound with 3 acid groups" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_ThreeAcids_1" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="PsJ8ewJsg06a57RUjeMacQ" name="pKa_ThreeBases_0" description="Smallest base pKa for compound with 3 base groups" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_ThreeBases_0" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="fynmaA0p-kyenQYNtt82xg" name="pKa_TwoAcids_0" description="Smallest acid pKa for compound with 2 acid groups" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_TwoAcids_0" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="hh3VPtaEh0SSrbbzy1IfWA" name="pKa_TwoBases_0" description="Smallest base pKa for compound with 2 base groups" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_TwoBases_0" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="-TQGvsLGAEO8zsdByhFqBQ" name="pKa_TwoBases_1" description="Middle base pKa for compound with 2 base groups" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_TwoBases_1" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="hlFTXQgcsECJ-g7FuxxtLg" name="Solubility gain per charge" description="Supporting parameter for calculation of pKa- and pH- dependent values of intestinal solubilty" persistable="0" isFixedValue="0" formula="vt9hfWV_6kqeOzZQ7EVPNQ" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="YsCqFBGU4UCPufLSF4xQ2g" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_RefpH_Factor" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="elyeUZx1F0aGJKiP5aV_OA" name="Total oral drug mass" description="Total oral drug mass" persistable="0" isFixedValue="0" formula="smHt76gkIE2twRVjCEu_1w" dim="Amount" quantityType="0" buildMode="Property" />
-            <Parameter id="uYl1IlnPlEWgJUYnTxEOjQ" name="pKa_ThreeBases_1" description="Middle base pKa for compound with 3 base groups" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_ThreeBases_1" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="NyKZM6uh9EqI2mlzB1uPFA" name="Cl" description="Number of chlorine atoms in molecule" persistable="0" isFixedValue="0" formula="D3CC4_5wrEaf_fJR78w5pw" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="2bL5qH68Y0SKqfCcAZMvmg" name="Br" description="Number of bromine atoms in molecule" persistable="0" isFixedValue="0" formula="rEK7ry4MGEiucblst7jLlQ" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="UUeEIGoYV06oxz6pmZ3uGg" name="Compound type 0" description="Compound type (-1: acid, +1: base, 0: neutral)" persistable="0" isFixedValue="0" formula="6-WYy2zMa0u3XRB4iayBVA" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="zVOk1V0Sd0qCo3hxMlYKEg" name="base_For_KaPL_Factor" description="Supporting parameter for calculation of pKa- and pH- dependent values of KaPL" persistable="0" isFixedValue="0" formula="hNwb244010m7NATzsHnxCQ" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="mZDvZYrvpkyiKTbkyz1yfw" name="base_For_logD_Factor" description="Supporting parameter for calculation of pKa- and pH- dependent logD" persistable="0" isFixedValue="0" formula="xs4c1cx-e0e2QQX0P22pew" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="dIBOa3w_DkGtnN4GOy11_Q" name="base_For_P_cell_Factor" description="Supporting parameter for calculation of pKa- and pH- dependent permeability to/from cells" persistable="0" isFixedValue="0" formula="WPR3n32FV02yCX-LMf-l5A" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="AuGmgC6L10yXUPWjhxe2Xg" name="base_For_Pint_Factor" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="4oH0NiNzikSj7dLR7gvBtg" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="VRsQLhm3q06qRjlGSlL63A" name="Lipophilicity" description="Model dependent lipophilicity measure: LogMA / LogP / ..." persistable="0" isFixedValue="0" formula="1gg8EoU9pEir90Cd-dKbAQ" dim="Lipophilicity" quantityType="0" buildMode="Property" />
-            <Parameter id="kkddlMbij0aN1iJUzdh0Iw" name="Fraction unbound (plasma)" description="Fraction unbound in plasma" persistable="0" isFixedValue="0" formula="-0q7ZLIm_kOGb9difHnPaw" dim="Fraction" quantityType="0" buildMode="Property" />
-            <Parameter id="FKVVdqcczk63P9dvFed3ig" name="Solubility at reference pH" description="Solubility at reference pH" persistable="0" isFixedValue="0" formula="PBq7ZblelkKaLUnkutmYrw" dim="Concentration" quantityType="0" buildMode="Property" />
-            <Parameter id="tCOoolnvIEKSM3HTS_pCiQ" name="Reference pH" description="Reference pH" persistable="0" isFixedValue="0" formula="gHDNQ-oiEE-BFjEy5a84nQ" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="qwfXLxeVWEaQ3YbluGElsA" name="Permeability" description="Permeability" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_P" dim="Velocity" quantityType="0" buildMode="Property" />
-            <Parameter id="2vaK-AuVtEWNeKkBb3MIdg" name="Specific intestinal permeability (transcellular)" description="Specific intestinal permeability (transcellular)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_InVitro" dim="Velocity" quantityType="0" buildMode="Property" />
-            <Parameter id="Xj3T91HsQEqskc-YoqgDrw" name="Partition coefficient (water/protein)" description="Partition coefficient water to protein" persistable="0" isFixedValue="0" formula="DistributionInVitro_PKSim.PARAM_KProt" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="2jiGbAQK5E6iurmxdTVb1A" name="Treat precipitated drug as" description="Treat precipitated drug as either soluble or insoluble" persistable="0" isFixedValue="0" formula="403R0GlXCE6hq84CoKf5UQ" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="fZXUT8xiHUC-uFQXNu8C1A" name="Aqueous diffusion coefficient" description="Aqueous diffusion coefficient&#xA;of the drug" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_Aqueous_diffusion_coefficient" dim="DiffusionCoefficient" quantityType="0" buildMode="Property" />
-            <Parameter id="JB5JTREvL0SIJwy823FNUg" name="Density (drug)" description="Density of drug material" persistable="0" isFixedValue="0" formula="vT0SLjzjmU-Sq71q5b7FxA" dim="Density" quantityType="0" buildMode="Property" />
-            <Parameter id="6VpgNB0tp02K90LLhBBHiA" name="Immediately dissolve particles smaller than" description="Threshold for the particle radius of immediate dissolution" persistable="0" isFixedValue="0" formula="T5Z2A5Xnr0WD2t8zcWctFQ" dim="Nanolength" quantityType="0" buildMode="Property" />
-            <Parameter id="VpqB90yEIUqVR7fPlw6QqQ" name="Radius (solute)" description="Solute radius" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_Ae" dim="Nanolength" quantityType="0" buildMode="Property" />
-            <Parameter id="vTacDJUgVkOiLUinuVpI7g" name="Kd (FcRn)" description="Dissociation constant for binding of drug to FcRn" persistable="0" isFixedValue="0" formula="5wvjPg8Nwk2VI05CY1M5uQ" dim="MolarConcentration" quantityType="0" buildMode="Property" />
-            <Parameter id="TbDUJIRbmE2q-OsYG6dfeg" name="Use pH- and pKa-dependent penalty factor for charged molecule fraction" description="Penalty factor for charged molecule fraction is used for &quot;Intestinal permeability (transcellular)&quot; only" persistable="0" isFixedValue="0" formula="pXYG8ZyFM0Osy5tgELW87A" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="ysYPInu9Ika9k3v9qTU0TQ" name="Concentration" persistable="0" isFixedValue="0" formula="ConcFormula" dim="MolarConcentration" quantityType="0" />
-          </Children>
-          <UsedCalculationMethods>
-            <UsedCalculationMethod category="DistributionCellular" calculationMethod="Cellular partition coefficient method - PK-Sim Standard" />
-            <UsedCalculationMethod category="DiffusionIntCell" calculationMethod="Cellular permeability - PK-Sim Standard" />
-            <UsedCalculationMethod category="DistributionInterstitial" calculationMethod="Interstitial partition coefficient method - Schmitt" />
-          </UsedCalculationMethods>
-        </MoleculeBuilder>
-        <MoleculeBuilder id="JjXu5fagDkSH5SM6ih7jww" name="Drug-Cyp Metabolite" mode="Logical" containerType="Other" isFloating="0" quantityType="Metabolite" defaultStartFormula="O3hi-jYiYE-bBbGkzlkvSA">
-          <Children>
-            <Parameter id="DfqcAbt3VE2YtHsI4Orgig" name="pKa_Acid_2" description="Largest acid pKa" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_Acid_2" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="wL6rwqP7ZU67xrvXLisCAA" name="pKa_pH_WS_sol_K1" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_K1" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="5S72EaKD60WFtEbCe8KSAA" name="Is triprotic base" description="Is triprotic base" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_IsTriproticBase" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="ZE1K5Gm5NU-dxg3SNXoC8w" name="Molecular weight" description="Molecular weight" persistable="0" isFixedValue="0" formula="O90Q_QN4REaP-zavI8x31A" dim="MolecularWeight" quantityType="0" buildMode="Property" />
-            <Parameter id="puP05QNy_0S-Nce1xGEKJg" name="pKa value 0" description="pKa value" persistable="0" isFixedValue="0" formula="nQL0HBGvNEuugcLgUBn7Dw" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="uXTxwXw6fUSMZS9jNtjpuA" name="pKa value 1" description="pKa value" persistable="0" isFixedValue="0" formula="Y2lN88eS-EqyBLjvF3VgFw" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="Gc8ZiXFPzkCG2pt2vLpEvw" name="pKa value 2" description="pKa value" persistable="0" isFixedValue="0" formula="l0iTKW7BjUmge8CFRRl2GQ" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="mXX9TGVCUEaX7qRUi7TF5w" name="Is strong base" description="Supporting parameter for partition coeffs in RR-Modell (at least one basic pKa&gt;=7)" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_HasStrongBase" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="MYJgjCcqjUWTJfrhr99hfw" name="pKa_Acid_1" description="Middle acid pKa" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_Acid_1" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="lgbK8BLekEeZkZVsvwbABw" name="Is small molecule" description="Treat compound as small molecule or not (if not, both organ specific and intestinal permeability will be set to zero)" persistable="0" isFixedValue="0" formula="xpLe-Fvy0k2JdlRTpKyfUw" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="07chYU3CAkua6_Kjrzusyg" name="pKa_Acids_Count" description="Number of acidic groups in compound" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_Acids_Count" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="ReStYt0nqk2uXMFhIsLKfQ" name="pKa_Base_0" description="Smallest base pKa" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_Base_0" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="2uJ_Lv4wdUKSF7HSHrTHUg" name="pKa_Base_1" description="Middle base pKa" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_Base_1" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="qi9WxzGjWk-uTtydkxfqVA" name="pKa_Base_2" description="Largest base pKa" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_Base_2" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="LjAcRB-JjEufQGU4zqpDxA" name="pKa_Bases_Count" description="Number of basic groups in compound" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_Bases_Count" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="2RfEuc6Z2U-PQXR8mlIwrA" name="pKa_OneAcid_0" description="Smallest acid pKa for compound with 1 acid group" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_OneAcid_0" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="A3YO6c7hNkivSIcZffZm9g" name="pKa_OneBase_0" description="Smallest base pKa for compound with 1 base group" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_OneBase_0" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="-m5kLbbYsUud-DKimHh8xw" name="pKa_pH_WS_sol_F1" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_F1" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="di_ZzCC5SEOrtS1_iAa7ww" name="pKa_pH_WS_sol_F2" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_F2" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="3Oo9qBkXeUOB_HL0R63lRA" name="pKa_Acid_0" description="Smallest acid pKa" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_Acid_0" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="9BiXYpA6Uk2cvUG-_MkTeg" name="I" description="Number of iodine atoms in molecule" persistable="0" isFixedValue="0" formula="f6rdLLFJ0UOpH1OJDP6b-Q" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="EL7xIduoE0WXHK_R1Vdg6A" name="Compound type 1" description="Compound type (-1: acid, +1: base, 0: neutral)" persistable="0" isFixedValue="0" formula="0e7QeV6z7Eagm4fT4Q248Q" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="_2QYcup1Hk-vRonZfzPh1w" name="Compound type 2" description="Compound type (-1: acid, +1: base, 0: neutral)" persistable="0" isFixedValue="0" formula="daIehZQK8UC5Z9RmvybI0A" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="sWGC-LyP2EmtzOgZ8WBGUA" name="CT_ACID" description="Constant for compound type acid" persistable="0" isFixedValue="0" formula="EN0ErM2EQESMnfLclc0kHw" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="Hbq2J2Xp4UayE0P7C3agkQ" name="CT_BASE" description="Constant for compound type base" persistable="0" isFixedValue="0" formula="tB4hpqVV6EW5gWDrQ0o-ww" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="mfQ6FOE0kUSjmVduVH5zkA" name="CT_NEUTRAL" description="Constant for compound type neutral" persistable="0" isFixedValue="0" formula="OxK_toM0tUKkQIy98inKWQ" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="59bj0-KRNkaiYZdAJFg5Kw" name="Effective molecular weight" description="Effective molecular weight" persistable="0" isFixedValue="0" formula="CompoundMW_PKSim.PARAM_MWEff" dim="MolecularWeight" quantityType="0" buildMode="Property" />
-            <Parameter id="Ar93YUNclEiQ09k6EyzFlw" name="F" description="Number of fluorine atoms in molecule" persistable="0" isFixedValue="0" formula="50TDQk-b5UK4SM_FsQfelQ" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="paRqDOnsDEydfD9fPfXS0w" name="Is triprotic acid" description="Is triprotic acid" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_IsTriproticAcid" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="tEpUkAtPs0iyR4iZdHW5Fg" name="Has halogens" description="Supporting parameter for compound" persistable="0" isFixedValue="0" formula="CompoundMW_PKSim.PARAM_HasHalogens" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="E7oZlfJ15UKYuoY4xamSmg" name="pKa_pH_WS_sol_K2" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_K2" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="XTFz_Q8GnEymhZN-XkvBpA" name="Is diprotic acid" description="Is diprotic acid" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_IsDiproticAcid" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="tHp7gYCttU6YOsRK4hR6Hw" name="Is diprotic base" description="Is diprotic base" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_IsDiproticBase" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="zdOrjUL6VkSzCuhXFskCfA" name="Is diprotic base monoprotic acid" description="Is diprotic base monoprotic acid" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_IsDiproticBaseMonoproticAcid" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="M5-7zwcX2k-Z_V14NOghUw" name="Is floating in lumen" description="Is floating in lumen" persistable="0" isFixedValue="0" formula="D8G-fwAMhkOqW23r5LobiQ" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="pzdDioTVxkSXvoQTWJAsuw" name="Is monoprotic acid" description="Is monoprotic acid" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_IsMonoproticAcid" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="o0z2t0Bui0aepiEOKQQ51A" name="Is monoprotic base" description="Is monoprotic base" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_IsMonoproticBase" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="JSFtnmz5S0GMETpou3tA3Q" name="Is monoprotic base diprotic acid" description="Is monoprotic base diprotic acid" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_IsMonoproticBaseDiproticAcid" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="hgUJnH9PTkqEikAXOS4r4A" name="Is monoprotic base monoprotic acid" description="Is monoprotic base monoprotic acid" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_IsMonoproticBaseMonoproticAcid" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="HFLbFVzPlUuERadrmnSlDA" name="Is neutral" description="Supporting parameter for partition coeffs in RR-Modell" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_IsNeutral" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="5kMZs49VxEOKjX-dSAjVnQ" name="pKa_pH_WS_sol_F3" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_F3" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="lh5JDtNJKkC0SIXM5R76pw" name="pKa_TwoAcids_1" description="Middle acid pKa for compound with 2 acid groups" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_TwoAcids_1" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="NDFdQZWYuEWC4xrsKU0s8Q" name="pKa_pH_WS_sol_K3" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_K3" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="6agpy_9zY0qUUmxRdnf5_A" name="pKa_pH_WS_sol_K4" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_K4" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="tsQ_dAAkHESwRGzgyK5qHg" name="pKa_pH_WS_sol_K5" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_K5" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="xMJvmcYxtEKnsgFdfYbXnQ" name="pKa_pH_WS_sol_K6" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_K6" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="EYycIg0-XEaCxn4DvU79Sg" name="pKa_pH_WS_sol_K7" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_K7" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="Jfkr10vxK02WfGfQ1eqG1g" name="pKa_pH_WS_sol_K8" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_K8" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="zXzXRhNdhke6f1jYl59Z5g" name="pKa_ThreeAcids_0" description="Smallest acid pKa for compound with 3 acid groups" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_ThreeAcids_0" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="z8Dncc3LG0arXYlbLKtL7A" name="pKa_ThreeAcids_1" description="Middle acid pKa for compound with 3 acid groups" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_ThreeAcids_1" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="2pLj4u2YdUqZ9fDTZdqzTw" name="pKa_ThreeBases_0" description="Smallest base pKa for compound with 3 base groups" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_ThreeBases_0" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="maLX-QWQOEiKmQz4SJO40A" name="pKa_TwoAcids_0" description="Smallest acid pKa for compound with 2 acid groups" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_TwoAcids_0" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="RBGKG_l2GEimKAYfzQavwA" name="pKa_TwoBases_0" description="Smallest base pKa for compound with 2 base groups" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_TwoBases_0" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="mSCDTfsyTkSpUkuLboKXXg" name="pKa_TwoBases_1" description="Middle base pKa for compound with 2 base groups" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_TwoBases_1" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="sy2IQrUiUUiuTO91ntHxCQ" name="Solubility gain per charge" description="Supporting parameter for calculation of pKa- and pH- dependent values of intestinal solubilty" persistable="0" isFixedValue="0" formula="68u4c30X0Ey9pfbHYeaalA" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="4v7rHs8gOUGeLL7CiPf2yQ" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_RefpH_Factor" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="uLqNLlB_v0OCqazw62w-xA" name="Total oral drug mass" description="Total oral drug mass" persistable="0" isFixedValue="0" formula="2H-VgpsphEybRlgwySBveg" dim="Amount" quantityType="0" buildMode="Property" />
-            <Parameter id="sXDVUpfjj0ioRGfI-g3bkQ" name="pKa_ThreeBases_1" description="Middle base pKa for compound with 3 base groups" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_ThreeBases_1" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="ihLTgI_nEEG5iae7eFie5g" name="Cl" description="Number of chlorine atoms in molecule" persistable="0" isFixedValue="0" formula="Jhkwf6miEU2xkrLpgPaQeQ" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="vlnKj44i1kiIuw0n-NOgMg" name="Br" description="Number of bromine atoms in molecule" persistable="0" isFixedValue="0" formula="2HI7abczp0Sm7xRz-KQclg" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="6ynsNADSzUaiUZG3h6S0vg" name="Compound type 0" description="Compound type (-1: acid, +1: base, 0: neutral)" persistable="0" isFixedValue="0" formula="tAAUMdyZh0SA0hxzmnUtWA" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="5qmXh9keYkO67TkNE8WxnQ" name="base_For_KaPL_Factor" description="Supporting parameter for calculation of pKa- and pH- dependent values of KaPL" persistable="0" isFixedValue="0" formula="cvHIGLZVy0-dTEXiC4kHog" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="9zrysr5cgUG1fZQqdzK-9A" name="base_For_logD_Factor" description="Supporting parameter for calculation of pKa- and pH- dependent logD" persistable="0" isFixedValue="0" formula="rPY_cBa_HEeECZz-2AlpdA" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="B7G1-DBI3EyNKavAH1_h0w" name="base_For_P_cell_Factor" description="Supporting parameter for calculation of pKa- and pH- dependent permeability to/from cells" persistable="0" isFixedValue="0" formula="oNCu6b4W_EO3kBxAso4vNA" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="jC1BAI5SoEmQlv0vdPm-eQ" name="base_For_Pint_Factor" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="z-8LOWhG-0i3qtxOeKHW2Q" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="1EOrgOdaNUOcUBs9hneyTA" name="Lipophilicity" description="Model dependent lipophilicity measure: LogMA / LogP / ..." persistable="0" isFixedValue="0" formula="vh7tOBhNik6Cr3bUFGgHTw" dim="Lipophilicity" quantityType="0" buildMode="Property" />
-            <Parameter id="n-S_OQWUaEiNGYroivKBhg" name="Fraction unbound (plasma)" description="Fraction unbound in plasma" persistable="0" isFixedValue="0" formula="dxJhgOaXlEObnNv7QfLUzw" dim="Fraction" quantityType="0" buildMode="Property" />
-            <Parameter id="A1VHE5BKNEadKB51eWqE-g" name="Solubility at reference pH" description="Solubility at reference pH" persistable="0" isFixedValue="0" formula="qal4JbqLl0qxnKw7X5Ph6g" dim="Concentration" quantityType="0" buildMode="Property" />
-            <Parameter id="mZYlXZb04kmrPE2ODHeRDg" name="Reference pH" description="Reference pH" persistable="0" isFixedValue="0" formula="Yfu-Nxi_l0uwaStFcuo_WA" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="aRexaygXGkijSbB1NwtStg" name="Permeability" description="Permeability" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_P" dim="Velocity" quantityType="0" buildMode="Property" />
-            <Parameter id="ZaBwAtFWaEqy_nDXyVDnZw" name="Specific intestinal permeability (transcellular)" description="Specific intestinal permeability (transcellular)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_InVitro" dim="Velocity" quantityType="0" buildMode="Property" />
-            <Parameter id="1ClieYeR3UeOMtjuDSzKeg" name="Partition coefficient (water/protein)" description="Partition coefficient water to protein" persistable="0" isFixedValue="0" formula="DistributionInVitro_PKSim.PARAM_KProt" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="QLX-u1h6lEi3rxg_dWJ6Ew" name="Treat precipitated drug as" description="Treat precipitated drug as either soluble or insoluble" persistable="0" isFixedValue="0" formula="tp00_JDrrk-QK8yQsoRZbQ" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="bqE4RKNuDEKVccIb50HWVQ" name="Aqueous diffusion coefficient" description="Aqueous diffusion coefficient&#xA;of the drug" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_Aqueous_diffusion_coefficient" dim="DiffusionCoefficient" quantityType="0" buildMode="Property" />
-            <Parameter id="JoF3b1RgLkaZLBAOPZAWJQ" name="Density (drug)" description="Density of drug material" persistable="0" isFixedValue="0" formula="ZhLl-ltvqUqg5ET8iMpbVA" dim="Density" quantityType="0" buildMode="Property" />
-            <Parameter id="XUIpG7A0Q06SrzZhztHL3g" name="Immediately dissolve particles smaller than" description="Threshold for the particle radius of immediate dissolution" persistable="0" isFixedValue="0" formula="pf88KUnryk2A2myTOplPeg" dim="Nanolength" quantityType="0" buildMode="Property" />
-            <Parameter id="b-zKpbcoFUOy3jppeiU4gQ" name="Radius (solute)" description="Solute radius" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_Ae" dim="Nanolength" quantityType="0" buildMode="Property" />
-            <Parameter id="XocdbE-CdUOj0Y6FLAkkow" name="Kd (FcRn)" description="Dissociation constant for binding of drug to FcRn" persistable="0" isFixedValue="0" formula="w_jOMWAz7kq0J8KSo7RSIQ" dim="MolarConcentration" quantityType="0" buildMode="Property" />
-            <Parameter id="kJoXOzPc8kuoc1zcF5A4_g" name="Use pH- and pKa-dependent penalty factor for charged molecule fraction" description="Penalty factor for charged molecule fraction is used for &quot;Intestinal permeability (transcellular)&quot; only" persistable="0" isFixedValue="0" formula="9pK84-LlBEuDRuO7oUhTlw" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="hywWbdxKXUKR5zYhYDydig" name="Concentration" persistable="0" isFixedValue="0" formula="ConcFormula" dim="MolarConcentration" quantityType="0" />
-          </Children>
-          <UsedCalculationMethods>
-            <UsedCalculationMethod category="DistributionCellular" calculationMethod="Cellular partition coefficient method - PK-Sim Standard" />
-            <UsedCalculationMethod category="DiffusionIntCell" calculationMethod="Cellular permeability - PK-Sim Standard" />
-            <UsedCalculationMethod category="DistributionInterstitial" calculationMethod="Interstitial partition coefficient method - Schmitt" />
-          </UsedCalculationMethods>
-        </MoleculeBuilder>
-      </Builders>
-      <FormulaCache>
-        <Formulas>
-          <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_Acid_2" name="PARAM_pKa_Acid_2" dim="Dimensionless" formula="IsTriproticAcid ? Max (pKa_0; Max (pKa_1; pKa_2)) : 0">
-            <Paths>
-              <Path path="0" as="1" />
-              <Path path="2" as="3" />
-              <Path path="4" as="5" />
-              <Path path="6" as="7" />
-            </Paths>
-          </Formula>
-          <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_sol_K1" name="PARAM_pKa_pH_WS_sol_K1" dim="Dimensionless" formula="F1*F2*F3">
-            <Paths>
-              <Path path="8" as="9" />
-              <Path path="10" as="11" />
-              <Path path="12" as="13" />
-            </Paths>
-          </Formula>
-          <Formula id="CompoundAcidBase_PKSim.PARAM_IsTriproticBase" name="PARAM_IsTriproticBase" dim="Dimensionless" formula="pKa_Acids_Count=0 &amp; pKa_Bases_Count = 3 ? 1 : 0">
-            <Paths>
-              <Path path="14" as="15" />
-              <Path path="16" as="17" />
-            </Paths>
-          </Formula>
-          <Formula id="CompoundAcidBase_PKSim.PARAM_HasStrongBase" name="PARAM_HasStrongBase" dim="Dimensionless" formula="(CT_0=1 AND pKa_0&gt;=7) OR (CT_1=1 AND pKa_1&gt;=7) OR (CT_2=1 AND pKa_2&gt;=7)">
-            <Paths>
-              <Path path="18" as="19" />
-              <Path path="20" as="21" />
-              <Path path="22" as="23" />
-              <Path path="2" as="3" />
-              <Path path="4" as="5" />
-              <Path path="6" as="7" />
-            </Paths>
-          </Formula>
-          <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_Acid_1" name="PARAM_pKa_Acid_1" dim="Dimensionless" formula="pKa_TwoAcids_1+pKa_ThreeAcids_1">
-            <Paths>
-              <Path path="24" as="25" />
-              <Path path="26" as="27" />
-            </Paths>
-          </Formula>
-          <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_Acids_Count" name="PARAM_pKa_Acids_Count" dim="Dimensionless" formula="(CT0 = CT_ACID ? 1 : 0) + (CT1 = CT_ACID ? 1 : 0) + (CT2 = CT_ACID ? 1 : 0)">
-            <Paths>
-              <Path path="18" as="28" />
-              <Path path="20" as="29" />
-              <Path path="22" as="30" />
-              <Path path="31" as="32" />
-            </Paths>
-          </Formula>
-          <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_Base_0" name="PARAM_pKa_Base_0" dim="Dimensionless" formula="pKa_OneBase_0+pKa_TwoBases_0+pKa_ThreeBases_0">
-            <Paths>
-              <Path path="33" as="34" />
-              <Path path="35" as="36" />
-              <Path path="37" as="38" />
-            </Paths>
-          </Formula>
-          <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_Base_1" name="PARAM_pKa_Base_1" dim="Dimensionless" formula="pKa_TwoBases_1+pKa_ThreeBases_1">
-            <Paths>
-              <Path path="39" as="40" />
-              <Path path="41" as="42" />
-            </Paths>
-          </Formula>
-          <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_Base_2" name="PARAM_pKa_Base_2" dim="Dimensionless" formula="IsTriproticBase ? Max (pKa_0; Max (pKa_1; pKa_2)) : 0">
-            <Paths>
-              <Path path="43" as="44" />
-              <Path path="2" as="3" />
-              <Path path="4" as="5" />
-              <Path path="6" as="7" />
-            </Paths>
-          </Formula>
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-            <Paths>
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-          <Formula id="SmDuODjwaU2noyWKUmWVZg" name="MassTransferOrgPl2BloodPool_pve" dim="Rate" formula="Q*(1-HCT)*C_pls">
-            <Paths>
-              <Path path="23" as="16" dim="17" />
-              <Path path="18" as="19" dim="20" />
-              <Path path="21" as="22" />
-            </Paths>
-          </Formula>
-          <Formula id="o0GoPp69ZEyrDwOozi4i5A" name="MassTransferOrgRBC2BloodPool" dim="Rate" formula="Q*HCT*C_bc">
-            <Paths>
-              <Path path="23" as="16" dim="17" />
-              <Path path="18" as="24" dim="20" />
-              <Path path="21" as="22" />
-            </Paths>
-          </Formula>
-          <Formula id="EcOw8jKajEu7r1wITvOXeA" name="MassTransferOrgRBC2BloodPool_Liv" dim="Rate" formula="(Q_liv +Q_pve)*HCT*C_bc">
-            <Paths>
-              <Path path="23" as="36" dim="17" />
-              <Path path="18" as="24" dim="20" />
-              <Path path="37" as="38" dim="17" />
-              <Path path="21" as="22" />
-            </Paths>
-          </Formula>
-          <Formula id="pP6ciEsSHkKVwNz0aDcXiw" name="MassTransferOrgRBC2BloodPool_Lng" dim="Rate" formula="Q*HCT*C_bc">
-            <Paths>
-              <Path path="23" as="16" dim="17" />
-              <Path path="18" as="24" dim="20" />
-              <Path path="21" as="22" />
-            </Paths>
-          </Formula>
-          <Formula id="gGqV3BIlyUSaRuElcybwwA" name="MassTransferOrgRBC2BloodPool_Pve" dim="Rate" formula="Q*HCT*C_bc">
-            <Paths>
-              <Path path="23" as="16" dim="17" />
-              <Path path="18" as="24" dim="20" />
-              <Path path="21" as="22" />
-            </Paths>
-          </Formula>
-          <Formula id="GUNEwM5NlUCZQ1IQdKi3GQ" name="PassiveDiffusionInt2Cell" dim="Rate" formula="K_water_int * PA_int_cell * C_int - K_water_cell * PA_cell_int * C_cell">
-            <Paths>
-              <Path path="39" as="40" dim="20" />
-              <Path path="18" as="41" dim="20" />
-              <Path path="42" as="43" dim="17" />
-              <Path path="44" as="45" dim="17" />
-              <Path path="46" as="47" />
-              <Path path="48" as="49" />
-            </Paths>
-          </Formula>
-          <Formula id="FMb0w01mnUi2_OgFzj7MFw" name="PassiveDiffusionPl2Int" dim="Rate" formula="fu * P_endothelial * SA /1000 * (C_pls - C_int / K_int_pls)">
-            <Paths>
-              <Path path="39" as="41" dim="20" />
-              <Path path="18" as="19" dim="20" />
-              <Path path="50" as="51" dim="52" />
-              <Path path="53" as="54" dim="55" />
-              <Path path="56" as="57" />
-              <Path path="58" as="59" dim="60" />
-            </Paths>
-          </Formula>
-          <Formula id="_WyZJiV2SkKfXxjAOoAM0w" name="PassiveDiffusionPl2RBC" dim="Rate" formula="SA_bc /1000 * fu * (P_pls_rbc * C_pls - P_rbc_pls * C_bc  /K_rbc)">
-            <Paths>
-              <Path path="39" as="24" dim="20" />
-              <Path path="18" as="19" dim="20" />
-              <Path path="50" as="51" dim="52" />
-              <Path path="61" as="62" dim="55" />
-              <Path path="63" as="64" dim="55" />
-              <Path path="65" as="66" />
-              <Path path="67" as="68" dim="60" />
-            </Paths>
-          </Formula>
-          <Formula id="XmQ29cIeWE-cO0xAeI8ZWw" name="PassiveDiffusionPlsToSaliva" dim="Rate" formula="fu * (C_pls_art - C_slv / K_slv_pls) * Q_slv">
-            <Paths>
-              <Path path="69" as="70" dim="17" />
-              <Path path="71" as="72" dim="20" />
-              <Path path="39" as="73" dim="20" />
-              <Path path="50" as="51" dim="52" />
-              <Path path="74" as="75" />
-            </Paths>
-          </Formula>
-          <Formula id="kbNwzXDtxUyT0cuDATI7tQ" name="GallbladderEmptyingRate" dim="Rate" formula="GallbladderEmptyingRate">
-            <Paths>
-              <Path path="76" as="77" dim="2" />
-            </Paths>
-          </Formula>
-        </Formulas>
-        <StringMap>
-          <Map s="NEIGHBORHOOD|MOLECULE|Drug absorption rate (lumen to mucosa)" id="0" />
-          <Map s="DrugAbsorptionLumenToMucosaRate" id="1" />
-          <Map s="Rate" id="2" />
-          <Map s="SOURCE|..|OralApplicationsEnabled" id="3" />
-          <Map s="OralApplicationsEnabled" id="4" />
-          <Map s="SOURCE|MOLECULE" id="5" />
-          <Map s="Drug" id="6" />
-          <Map s="Amount" id="7" />
-          <Map s="MOLECULE|Is floating in lumen" id="8" />
-          <Map s="IsFloatingInLumen" id="9" />
-          <Map s="SOURCE|Intestinal transit rate (absolute)" id="10" />
-          <Map s="w" id="11" />
-          <Map s="InversedTime" id="12" />
-          <Map s="TARGET|FillLevelFlag" id="13" />
-          <Map s="FillLevelFlagNext" id="14" />
-          <Map s="TARGET|..|Blood flow rate" id="15" />
-          <Map s="Q" id="16" />
-          <Map s="Flow (volume)" id="17" />
-          <Map s="SOURCE|MOLECULE|Concentration" id="18" />
-          <Map s="C_pls" id="19" />
-          <Map s="MolarConcentration" id="20" />
-          <Map s="Organism|Hematocrit" id="21" />
-          <Map s="HCT" id="22" />
-          <Map s="SOURCE|..|Blood flow rate" id="23" />
-          <Map s="C_bc" id="24" />
-          <Map s="SOURCE|..|Mucosa blood flow fraction" id="25" />
-          <Map s="fractQ" id="26" />
-          <Map s="C" id="27" />
-          <Map s="NEIGHBORHOOD|MOLECULE|Mass transfer rate (intestine to mucosa blood cells)" id="28" />
-          <Map s="MassTransferIntestineToMucosaBCRate" id="29" />
-          <Map s="NEIGHBORHOOD|MOLECULE|Mass transfer rate (intestine to mucosa plasma)" id="30" />
-          <Map s="MassTransferIntestineToMucosaPlasmaRate" id="31" />
-          <Map s="NEIGHBORHOOD|MOLECULE|Mass transfer rate (mucosa to portal vein blood cells)" id="32" />
-          <Map s="MassTransferMucosaToPveBCRate" id="33" />
-          <Map s="NEIGHBORHOOD|MOLECULE|Mass transfer rate (mucosa to portal vein plasma)" id="34" />
-          <Map s="MassTransferMucosaToPvePlasmaRate" id="35" />
-          <Map s="Q_liv" id="36" />
-          <Map s="SOURCE|..|..|PortalVein|Blood flow rate" id="37" />
-          <Map s="Q_pve" id="38" />
-          <Map s="TARGET|MOLECULE|Concentration" id="39" />
-          <Map s="C_cell" id="40" />
-          <Map s="C_int" id="41" />
-          <Map s="NEIGHBORHOOD|MOLECULE|P*SA interstitial -&gt; intracellular" id="42" />
-          <Map s="PA_int_cell" id="43" />
-          <Map s="NEIGHBORHOOD|MOLECULE|P*SA intracellular -&gt; interstitial" id="44" />
-          <Map s="PA_cell_int" id="45" />
-          <Map s="NEIGHBORHOOD|MOLECULE|Partition coefficient (interstitial/water)" id="46" />
-          <Map s="K_water_int" id="47" />
-          <Map s="NEIGHBORHOOD|MOLECULE|Partition coefficient (intracellular/water)" id="48" />
-          <Map s="K_water_cell" id="49" />
-          <Map s="MOLECULE|Fraction unbound (plasma)" id="50" />
-          <Map s="fu" id="51" />
-          <Map s="Fraction" id="52" />
-          <Map s="NEIGHBORHOOD|MOLECULE|P (plasma&lt;-&gt;interstitial)" id="53" />
-          <Map s="P_endothelial" id="54" />
-          <Map s="Velocity" id="55" />
-          <Map s="NEIGHBORHOOD|MOLECULE|Partition coefficient (interstitial/plasma)" id="56" />
-          <Map s="K_int_pls" id="57" />
-          <Map s="NEIGHBORHOOD|Surface area (plasma/interstitial)" id="58" />
-          <Map s="SA" id="59" />
-          <Map s="Surface" id="60" />
-          <Map s="MOLECULE|P (blood cells-&gt;plasma)" id="61" />
-          <Map s="P_rbc_pls" id="62" />
-          <Map s="MOLECULE|P (plasma-&gt;blood cells)" id="63" />
-          <Map s="P_pls_rbc" id="64" />
-          <Map s="MOLECULE|Partition coefficient (blood cells/plasma)" id="65" />
-          <Map s="K_rbc" id="66" />
-          <Map s="NEIGHBORHOOD|Surface area (blood cells/plasma)" id="67" />
-          <Map s="SA_bc" id="68" />
-          <Map s="SOURCE|..|Saliva flow rate" id="69" />
-          <Map s="Q_slv" id="70" />
-          <Map s="SOURCE|..|..|ArterialBlood|Plasma|MOLECULE|Concentration" id="71" />
-          <Map s="C_pls_art" id="72" />
-          <Map s="C_slv" id="73" />
-          <Map s="NEIGHBORHOOD|MOLECULE|Partition coefficient (intracellular/plasma)" id="74" />
-          <Map s="K_slv_pls" id="75" />
-          <Map s="Organism|Gallbladder|Gallbladder emptying rate" id="76" />
-          <Map s="GallbladderEmptyingRate" id="77" />
-        </StringMap>
-      </FormulaCache>
-    </PassiveTransports>
-    <Reactions id="d2wExONkDkWChTPkcPmNzQ" name="T1">
-      <Builders>
-        <ReactionBuilder id="-RMt8K-hiU2_yT0aQNwmvA" name="Cyp-ME" icon="Metabolism" formula="KV3OPFY8kUGXbJFRrxuMOQ">
-          <Educts>
-            <ReactionPartnerBuilder moleculeName="Drug" stoichiometricCoefficient="1" />
-          </Educts>
-          <Products>
-            <ReactionPartnerBuilder moleculeName="Drug-Cyp Metabolite" stoichiometricCoefficient="1" />
-          </Products>
-          <ModifierNames>
-            <ModifierNamesChild>Cyp</ModifierNamesChild>
-          </ModifierNames>
-          <Parameters>
-            <Parameter id="Y9jckvZBRkWTqcke9AZBJQ" name="Volume (liver)" description="Volume of the liver" persistable="0" isFixedValue="0" formula="INAaAi7WNk677teyxfnH0A" dim="Volume" quantityType="0" buildMode="Global" />
-            <Parameter id="4HgwZLHm_kubrdc7QhWtHg" name="Enzyme concentration" description="Enzyme concentration in organ of individual where the process took place or in the assay where the experiment was performed" persistable="0" isFixedValue="0" formula="zDg2njdQvU-L_4CINgSzKA" dim="MolarConcentration" quantityType="0" buildMode="Global" />
-            <Parameter id="BgNqvF6ct0yOrJOhppc6ew" name="CLspec/[Enzyme]" description="Specific clearance normalized to the enzyme concentration" persistable="0" isFixedValue="0" formula="rGpXoK3Yv0mp7vdznUG7fA" dim="SpecificClearancePerProtein" quantityType="0" buildMode="Global" />
-            <Parameter id="P-43UtXyt0mvCjmrqQVPFg" name="Fraction intracellular (liver)" description="Fraction of intracellular space of the liver" persistable="0" isFixedValue="0" formula="8PrDIq7KEkqC_q_MYAVTAA" dim="Dimensionless" quantityType="0" buildMode="Global" />
-            <Parameter id="lRiI3dKhv06IRZExspCmKg" name="Intrinsic clearance" description="Intrinsic clearance" persistable="0" isFixedValue="0" formula="bXlMLo5Cu0-rsxjkFigMJg" dim="Flow (volume)" quantityType="0" buildMode="Global" />
-            <Parameter id="p4ORrbtXWkK1JN6d7Hf7yw" name="Specific clearance" description="Intrinsic clearance normalized to the volume where the process occurs" persistable="0" isFixedValue="0" formula="T-MJDDP-vUiKyCbr1wf9LQ" dim="InversedTime" quantityType="0" buildMode="Global" />
-          </Parameters>
-        </ReactionBuilder>
-      </Builders>
-      <FormulaCache>
-        <Formulas>
-          <Formula id="KV3OPFY8kUGXbJFRrxuMOQ" name="Cyp-ME-Metabolization_FirstOrder" dim="Rate" formula="CP * CLspecPerEnzyme * M * K_water">
-            <Paths>
-              <Path path="0" as="1" dim="2" />
-              <Path path="3" as="4" dim="5" />
-              <Path path="6" as="7" />
-              <Path path="8" as="9" dim="10" />
-            </Paths>
-          </Formula>
-          <ConstantFormula id="INAaAi7WNk677teyxfnH0A" dim="Dimensionless" value="2.3578466712" />
-          <ConstantFormula id="zDg2njdQvU-L_4CINgSzKA" dim="Dimensionless" value="1" />
-          <Formula id="rGpXoK3Yv0mp7vdznUG7fA" name="PARAM_CLSpecPerEnzyme_From_CLSpec" dim="SpecificClearancePerProtein" formula="CLspec / EnzymeConcentration">
-            <Paths>
-              <Path path="11" as="12" dim="2" />
-              <Path path="13" as="14" dim="15" />
-            </Paths>
-          </Formula>
-          <ConstantFormula id="8PrDIq7KEkqC_q_MYAVTAA" dim="Dimensionless" value="0.667" />
-          <ConstantFormula id="bXlMLo5Cu0-rsxjkFigMJg" dim="Dimensionless" value="0.25" />
-          <Formula id="T-MJDDP-vUiKyCbr1wf9LQ" name="PARAM_CLSpec_From_CLInt" dim="SpecificClearancePerProtein" formula="CLInt / (V * f_cell)">
-            <Paths>
-              <Path path="16" as="17" />
-              <Path path="18" as="19" dim="20" />
-              <Path path="21" as="22" dim="23" />
-            </Paths>
-          </Formula>
-        </Formulas>
-        <StringMap>
-          <Map s="..|Cyp|Concentration" id="0" />
-          <Map s="CP" id="1" />
-          <Map s="MolarConcentration" id="2" />
-          <Map s="..|Drug" id="3" />
-          <Map s="M" id="4" />
-          <Map s="Amount" id="5" />
-          <Map s="..|Drug|Partition coefficient (water/container)" id="6" />
-          <Map s="K_water" id="7" />
-          <Map s="Cyp-ME|CLspec/[Enzyme]" id="8" />
-          <Map s="CLspecPerEnzyme" id="9" />
-          <Map s="SpecificClearancePerProtein" id="10" />
-          <Map s="..|Enzyme concentration" id="11" />
-          <Map s="EnzymeConcentration" id="12" />
-          <Map s="..|Specific clearance" id="13" />
-          <Map s="CLspec" id="14" />
-          <Map s="InversedTime" id="15" />
-          <Map s="..|Fraction intracellular (liver)" id="16" />
-          <Map s="f_cell" id="17" />
-          <Map s="..|Intrinsic clearance" id="18" />
-          <Map s="CLInt" id="19" />
-          <Map s="Flow (volume)" id="20" />
-          <Map s="..|Volume (liver)" id="21" />
-          <Map s="V" id="22" />
-          <Map s="Volume" id="23" />
-        </StringMap>
-      </FormulaCache>
-    </Reactions>
-    <SpatialStructure id="Qwk1nE9efkex98DTb78Yeg" name="T1">
-      <GlobalMoleculeDependentProperties id="V5iExdhmWUup_PcpOmIAIg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-        <Children>
-          <Parameter id="tj4aKuzStUOPvvxFUfDIHQ" name="Intestinal permeability (paracellular)" description="Intestinal permeability via paracellular route" persistable="0" isFixedValue="0" formula="cwfmgQX9Jk685-mtN0lOCg" dim="Velocity" quantityType="0" buildMode="Global" />
-          <Parameter id="LAZzxikN80eeJiESFMgPqg" name="P_bc_pls_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" dim="Dimensionless" quantityType="0" buildMode="Global" />
-          <Parameter id="i8uMShgVeUqZ2xaxjmvxuQ" name="P (blood cells-&gt;plasma)" description="Permeability from blood cells to plasma" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_P_rbc_pls" dim="Velocity" quantityType="0" buildMode="Global" />
-          <Parameter id="vVQ9k6lp6EmuJdsOZN4IWw" name="Partition coefficient (blood/plasma)" description="Partition coefficient between blood and plasma" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_bld" dim="Dimensionless" quantityType="0" buildMode="Global" />
-          <Parameter id="yqPEHhws-0aCE9SczJUvqw" name="Partition coefficient (blood cells/plasma)" description="Partition coefficient between blood cells and plasma" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" dim="Dimensionless" quantityType="0" buildMode="Global" />
-          <Parameter id="ilw5DRxYuEyqiVEYsQS50Q" name="P_pls_bc_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" dim="Dimensionless" quantityType="0" buildMode="Global" />
-          <Parameter id="I9N6sqjyXUCM_-nzxF6_mg" name="P (plasma-&gt;blood cells)" description="Permeability from plasma to blood cells" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_P_pls_rbc" dim="Velocity" quantityType="0" buildMode="Global" />
-          <Parameter id="5M94RBiTSUWfSzpVFkPGew" name="Intestinal permeability (transcellular)" description="Intestinal permeability via transcellular route" persistable="0" isFixedValue="0" formula="IntestinalPermeability_PKSim.PARAM_P_int" dim="Velocity" quantityType="0" buildMode="Global" />
-        </Children>
-      </GlobalMoleculeDependentProperties>
-      <TopContainers>
-        <Container id="xC3bd71YUEKNjG8bBp_yMQ" name="Organism" description="Organism" icon="Organism" mode="Logical" containerType="Organism">
-          <Tags>
-            <Tag value="Organism" />
-          </Tags>
-          <Children>
-            <Parameter id="QKT5zehFq0yO2mh0SoXUUw" name="BMI" description="Body mass index" persistable="0" isFixedValue="0" formula="BMI.PARAM_BMI" dim="BMI" quantityType="0" />
-            <Parameter id="EdR5hfjHa02lyGHARradcQ" name="Weight" description="Body weight" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_BW" dim="Mass" quantityType="0" />
-            <Parameter id="BS1eSBPNbkuHqPexW2rufg" name="Volume (plasma)" description="Whole body plasma volume" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_VolumePlasma" dim="Volume" quantityType="0" />
-            <Parameter id="JBTQv4SmJ0uX3ZOAektAEA" name="Estimated gestational age" description="Estimated gestational age" persistable="0" isFixedValue="0" formula="GFR_Calculation.PARAM_PostMenstrualAge" dim="AgeInWeeks" quantityType="0" />
-            <Parameter id="hZt47-10uE2qyCLzbiu5tw" name="Surface area scaling exponent" description="Global shape parameter; used (as exponent) for calculating diffusion stream between plasma and interstitial space" persistable="0" isFixedValue="0" formula="2m5pJqJLokaWmfaNXijqHg" dim="Dimensionless" quantityType="0" />
-            <Parameter id="EVK8k8DM106WM6nj7XC77Q" name="SA proportionality factor" description="Proportionality factor for the surface area plasma &lt;=&gt; int" persistable="0" isFixedValue="0" formula="bJ1wVntY1kCLJlez-aPAbA" dim="Dimensionless" quantityType="0" />
-            <Parameter id="VVZH49uFC02sFksDpQ9btA" name="Specific clearance (endosome)" description="Specific endosomal clearance" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_CLSpec_endosomal_global" dim="InversedTime" quantityType="0" />
-            <Parameter id="UnL3Yx3jrUWW-MWJZ0yD6Q" name="Vf (lipid, blood cells)" description="Fractional volume content of lipid in blood cells" persistable="0" isFixedValue="0" formula="pV7jUY615E607oos4H0cHg" dim="Dimensionless" quantityType="0" />
-            <Parameter id="W2XU3T4JZUygg6o2vgx7KQ" name="Vf (water,blood cells)" description="Fractional volume content of water in blood cells used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="wYnC3WmtL0e_Uh2L7FCvVw" dim="Dimensionless" quantityType="0" />
-            <Parameter id="eAfBPYzfXUeFj0ybiU72XQ" name="FcRn receptor conc. (endosome)" description="Concentration of FcRn receptor in endosomal space" persistable="0" isFixedValue="0" formula="eOubYQYDNEq64Y23EoQadw" dim="MolarConcentration" quantityType="0" />
-            <Parameter id="RyjdMvl_P0ipoFllTCXkbw" name="Vf (water,interstitial)" description="Fractional volume content of water in interstitial space used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="1XY0h82Jykq1-wg6D3iY4Q" dim="Dimensionless" quantityType="0" />
-            <Parameter id="W60LOByUF0SK6B54QkBIyw" name="Protein ratio (interstial/plasma)" description="The ratio between the protein volume fraction in interstitial space and plasma" persistable="0" isFixedValue="0" formula="WFFJASYONky7z94cQJWsJQ" dim="Dimensionless" quantityType="0" />
-            <Parameter id="y2-v0nFFuUmGzqFV3mz3FA" name="Vf (protein,plasma)" description="Fractional volume content of protein in plasma used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="y3rFfjkNdkuR5Ck_cQ4yoA" dim="Dimensionless" quantityType="0" />
-            <Parameter id="ww2NL7oSEEuWUNV3Vr50Ww" name="Vf (protein,blood cells)" description="Fractional volume content of protein in blood cells used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="4e3R-I9960WXi9CuaXM_mQ" dim="Dimensionless" quantityType="0" />
-            <Parameter id="2WoaVvx5t0i9LaIeik8DRQ" name="Vf (neutral lipid, plasma)-RR" description="Fractional volume content of neutral lipid in plasma used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="0F2VkcspAkOJb1TkISCjCw" dim="Dimensionless" quantityType="0" />
-            <Parameter id="uMkVPEfudUaCGCr-AbKX_w" name="Vf (neutral lipid, blood cells)-WS" description="Fractional volume content of neutral lipid in blood cells used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="1lj5mluiMUOGSQo7jUTzVw" dim="Dimensionless" quantityType="0" />
-            <Parameter id="nmrf09wyt0GHy2dIDBvWdg" name="Vf (lipid, plasma)" description="Fractional volume content of lipid in plasma" persistable="0" isFixedValue="0" formula="NXbjJ7tC_0iFEnI-GxKpJQ" dim="Dimensionless" quantityType="0" />
-            <Parameter id="Uxzw7CQLCEGNAWF7WTF7FQ" name="Vf (water,plasma)" description="Fractional volume content of water in plasma used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="JCKT1N-QeEm2FkAtZtYT2g" dim="Dimensionless" quantityType="0" />
-            <Parameter id="E9wdiS6q5EykvpJoko_plw" name="Na" description="Avogadro constant" persistable="0" isFixedValue="0" formula="EZL_mfONkEqGQjESCrTDkQ" dim="InversedMol" quantityType="0" />
-            <Parameter id="IzHU-Crm4Uei3ufEt8f83Q" name="R*T" description="Gas constant-body temperature product (37°C)" persistable="0" isFixedValue="0" formula="eZo6LVJYfU2Ekv9Qsk42pw" dim="RT" quantityType="0" />
-            <Parameter id="SEj8rochsUOYTROSg4vuUA" name="Age" description="Age" persistable="0" isFixedValue="0" formula="uTHBvpiZwUWrEvdhBbKCbg" dim="Age" quantityType="0" />
-            <Parameter id="-yNsN4qVYU-sONfMJ6vrMQ" name="Rate constant for recycling from endosomal space (global)" description="Rate constant for recycling from endosomal space for all organs" persistable="0" isFixedValue="0" formula="ReMiI5nupkuv0spAL1eN8A" dim="InversedTime" quantityType="0" />
-            <Parameter id="-G3HLsBRx02oTJBTrQk0Ug" name="Rate constant for endosomal uptake (global)" description="Rate constant for endosomal uptake for all organs" persistable="0" isFixedValue="0" formula="yETEW7beXkqbfzmyn0cH7g" dim="InversedTime" quantityType="0" />
-            <Parameter id="5UJg7ehA3U2wjdV_tzx1Jg" name="Fraction recycled to plasma (global)" description="Fraction of recycled drug to plasma relative to recycling to interstitial space" persistable="0" isFixedValue="0" formula="PKGudC26pkmb7zCm7LbtjA" dim="Fraction" quantityType="0" />
-            <Parameter id="l7L7gFrANkCtNO1dAcneJQ" name="Fraction of endosomal uptake from plasma (global)" description="Fraction of drug uptake from plasma into endosomal space relative to uptake from interstitial space" persistable="0" isFixedValue="0" formula="cFyAhNxilEuhfhGZvf8o9g" dim="Fraction" quantityType="0" />
-            <Parameter id="84Y8sh1A1kmJDO8cCXbAhw" name="Surface/Volume ratio (blood cells)" description="Surface area to volume ratio of blood cells" persistable="0" isFixedValue="0" formula="aliUihhovkqtFlG23drw6g" dim="Dimensionless" quantityType="0" />
-            <Parameter id="qBvWRb2eWke1w05HJF2Gow" name="pH (blood cells)" description="Intracellular pH of blood cells" persistable="0" isFixedValue="0" formula="xVNj2bwQpk-_CqTy4ECCPQ" dim="Dimensionless" quantityType="0" />
-            <Parameter id="QI-AIYHGTkyDdtv6zu6zpg" name="pH (interstitial)" description="pH of interstitial space" persistable="0" isFixedValue="0" formula="RA3e0qXTpUGwSP93VxUjhQ" dim="Dimensionless" quantityType="0" />
-            <Parameter id="23ocZfiPYki4W7PsGeOb7A" name="pH (intracellular)" description="pH of intracellular space" persistable="0" isFixedValue="0" formula="ZuIoFbWkm0mhuOxhw_eMYA" dim="Dimensionless" quantityType="0" />
-            <Parameter id="8K_u7nlz4Ea_b-Tn8JUaUA" name="pH (plasma)" description="pH of plasma" persistable="0" isFixedValue="0" formula="9PCTssAtpEKYYKPfbV7A5A" dim="Dimensionless" quantityType="0" />
-            <Parameter id="Rpdo1SjQokifYsGorKCoYg" name="Thickness (endothelium)" description="Thickness of vascular endothelium" persistable="0" isFixedValue="0" formula="XgDv8egruUiFpscLAdnoxw" dim="Length" quantityType="0" />
-            <Parameter id="1iI1dsGQ4EupUNV0Bg-nTA" name="Height" description="Body height" persistable="0" isFixedValue="0" formula="ol3MD6deykSXe95oS0ypDQ" dim="Length" quantityType="0" />
-            <Parameter id="K74su1Mu50SPU5Zc9fZW8Q" name="Fraction endosomal (global)" description="Fraction of endosomal space in vascular endothelium" persistable="0" isFixedValue="0" formula="w59qfPnlmEGNBYU8wjxI9Q" dim="Fraction" quantityType="0" />
-            <Parameter id="M3vfCKbN_Uiu57UZmK1Wzw" name="Vf (neutral phospholipid, blood cells)-WS" description="Fractional volume content of neutral phospholipid in blood cells used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="C_Frqvsk3kmmCzVZj3ucUA" dim="Dimensionless" quantityType="0" />
-            <Parameter id="hCxNxXhJxEu_0iSUQPGK9w" name="Vf (neutral lipid, plasma)-PT" description="Fractional volume content of neutral lipid in plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="50hLftkmpk6RrrQ8Sux_iA" dim="Dimensionless" quantityType="0" />
-            <Parameter id="z_Uq0BnCm0u4NDVCh6xJyw" name="Vf (neutral phospholipid, plasma)-RR" description="Fractional volume content of neutral phospholipid in plasma used in ithe partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="ZiAMr4xOMEa6vmN7w1sYcw" dim="Dimensionless" quantityType="0" />
-            <Parameter id="q0vA5xZ_jUWdH2OMUnoS0w" name="Vf (acidic phospholipids, blood cells)-WS" description="Fractional volume content of acidic phospholipid in blood cells used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="AOh2tg6Zd0KZyGvDWZyGeQ" dim="Dimensionless" quantityType="0" />
-            <Parameter id="DmeQ43oBDEumH7CHR7U2Tw" name="Vf (phospholipid, plasma)-PT" description="Fractional volume content of phospholipid in plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="AUGrLKfXH0Ks7OM7qsXEZw" dim="Dimensionless" quantityType="0" />
-            <Parameter id="q7lCFxS3ykCV1zCLWtoYEQ" name="Vf (neutral lipid, blood cells)-RR" description="Fractional volume content of neutral lipid in blood cells used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="DkbcHzARjkmn3g4hDsaLAQ" dim="Dimensionless" quantityType="0" />
-            <Parameter id="TjgrqnRxbECw2gHMGWgfiQ" name="Vf (neutral phospholipid, blood cells)-RR" description="Fractional volume content of neutral phospholipid in blood cells used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="YSHKwyAO0EO79z35FV4Jfw" dim="Dimensionless" quantityType="0" />
-            <Parameter id="IH_RfdWTc0KwQne2OL1xEw" name="Vf (water,plasma)-PT" description="Fractional volume content of water in plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="uOxTgG8EuEye7zcqPMbcnA" dim="Dimensionless" quantityType="0" />
-            <Parameter id="9jg080wlR0CyT16qpyPH6g" name="Acidic phospholipids (blood cells) [mg/g] - RR" description="Concentration of acidic phospholipids in red blood cells [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="CNHeir4ivU2XEsokD96yYw" dim="Dimensionless" quantityType="0" />
-            <Parameter id="Ky0VB5w-5kmcv_Nq8ukxxA" name="Vf (intracellular water, blood cells)-RR" description="Fractional volume content of intracellular water in blood cells used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="zHnuQqf2z0GdA8elCuRQYw" dim="Dimensionless" quantityType="0" />
-            <DistributedParameter id="kxOA8OcvNU6YodArHd8UgA" name="MeanBW" description="Weight" persistable="1" isFixedValue="0" formula="2RAD3NZdBUm2fRm_XBhSqA" dim="Mass" quantityType="0" mode="Logical">
-              <Children>
-                <Parameter id="sg3NT6Eq40mxWYOLIlykQw" name="Percentile" persistable="0" isFixedValue="0" formula="YxYuWXlYSEy8c9Rk2VnQ0A" dim="Dimensionless" quantityType="0" />
-                <Parameter id="dzvYsS_wbEa_z1kxbQDy_w" name="Mean" persistable="0" isFixedValue="0" formula="QDmVMhsBoEKqadyVHpQ4_w" dim="Mass" quantityType="0" />
-                <Parameter id="McxGzlXXQkStyEmadfCZZA" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" formula="tWrxAK-0F0mdCtfSlfetHw" dim="Mass" quantityType="0" />
-              </Children>
-            </DistributedParameter>
-            <DistributedParameter id="CL1VHlsHfEKSKMYdF_zQZg" name="MeanHeight" description="Height" persistable="1" isFixedValue="0" formula="rcJyXzBoB06MGhymylD3Bg" dim="Length" quantityType="0" mode="Logical">
-              <Children>
-                <Parameter id="jDmThOM0a0KU9ob-u49Y9Q" name="Percentile" persistable="0" isFixedValue="0" formula="dxC1ecGHmkKVwBiI3GNrpw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="SsDtvCwvn0Oh9w2dVmibWA" name="Mean" persistable="0" isFixedValue="0" formula="2Ns1aa4qvUycFpdIbhyynw" dim="Length" quantityType="0" />
-                <Parameter id="yZcXdXdLA0SnmMKKZwnb4g" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" formula="a3gdi0P_XkW68MPADR_ylQ" dim="Length" quantityType="0" />
-              </Children>
-            </DistributedParameter>
-            <DistributedParameter id="tK7uuJ-mqUqbkJ5mnKVqdw" name="Hematocrit" description="Hematocrit" persistable="1" isFixedValue="0" formula="MiRweV5Hck2Pas02gCbGPQ" dim="Dimensionless" quantityType="0" mode="Logical">
-              <Children>
-                <Parameter id="Tp25zBZqik2uCUxOhoLgmQ" name="Percentile" persistable="0" isFixedValue="0" formula="TOdYDpJzGUyWyYB9tPsijg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="i7pttH5ulU6DTdhFBaEXSA" name="Mean" persistable="0" isFixedValue="0" formula="BP8a6IIRk0y7uY9L81fU4g" dim="Dimensionless" quantityType="0" />
-              </Children>
-            </DistributedParameter>
-            <Container id="xgdhW0vf40GB-0JVWSLR_Q" name="PeripheralVenousBlood" description="Peripheral Venous Blood" icon="VenousBlood" mode="Logical" containerType="Organ">
-              <Tags>
-                <Tag value="PeripheralVenousBlood" />
-              </Tags>
-              <Children>
-                <Parameter id="fr-1vL1GF0-OqPK8cuFqLw" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" formula="0j_N-7vDJEaNFlnP9i15nw" dim="Density" quantityType="0" />
-              </Children>
-            </Container>
-            <Container id="Vtw2-oLrLk2V1UvOk4626A" name="VenousBlood" description="VenousBlood" icon="VenousBlood" mode="Logical" containerType="Organ">
-              <Tags>
-                <Tag value="VenousBlood" />
-                <Tag value="BloodOrgan" />
-              </Tags>
-              <Children>
-                <Parameter id="xOdHUeIeVkmzTY4aGWLlKw" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" persistable="0" isFixedValue="0" formula="McbcxygrjEGtYershyuqZw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="VjE4m6IRR02HZY9ATseYEA" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" formula="_7DP15DJYEubzJbEsPjzJA" dim="Density" quantityType="0" />
-                <Parameter id="KKZq60GJmEK2TKfZSvREFQ" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" formula="GUFXSxrs6ESV5lzr7IHdiA" dim="Dimensionless" quantityType="0" />
-                <DistributedParameter id="sJc9J1KLAUGwfYIaD7ogVQ" name="Volume" description="Volume of organ or compartment" persistable="1" isFixedValue="0" formula="yAaygTopfESC3NkYhBe7dw" dim="Volume" quantityType="0" mode="Logical">
-                  <Children>
-                    <Parameter id="PAjIsBkZ1kyHXRVLAAcnaQ" name="Percentile" persistable="0" isFixedValue="0" formula="V6kXZ066WEWil4kkLEkJPw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="L6edLYVwG0W_KxqIKbMBLw" name="Mean" persistable="0" isFixedValue="0" formula="TzgoFPYkekKmam2DxFFt0g" dim="Volume" quantityType="0" />
-                    <Parameter id="VQTL02tCP06HblrFGrtTcw" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" formula="DFDRBv-vSU-ehDi3XpLEcQ" dim="Volume" quantityType="0" />
-                  </Children>
-                </DistributedParameter>
-                <Container id="j2n6uKMQM0uCZWZ--9NUbg" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Plasma" />
-                    <Tag value="BloodOrgan" />
-                    <Tag value="VenousBlood" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="ZOGZRvjAWECThRcpXNOX4g" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                    <Parameter id="2br38kPD_0qrO9vZpHqdsQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_pls_BloodOrgan_4Comp" dim="Volume" quantityType="0" />
-                    <Container id="whlDIFZQQEyhF9Ak19Dgug" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Tags>
-                        <Tag value="MoleculeProperties" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="AeSB92U790WvNOCggRDhlA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" dim="Dimensionless" quantityType="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="td5KxHkAVkiuQetPlAwgVQ" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="BloodCells" />
-                    <Tag value="BloodOrgan" />
-                    <Tag value="VenousBlood" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="j3gqSfSPWEq3v4_d9IEkGA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                    <Parameter id="akSHqiCd7Em1fGHCt305OQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_bc_blood_organ_4comp" dim="Volume" quantityType="0" />
-                    <Container id="GXkM5zdTaU-HYT_hU39t5Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Tags>
-                        <Tag value="MoleculeProperties" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="NZBjqSUcHkuHObjJeUdQTg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" dim="Dimensionless" quantityType="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-              </Children>
-            </Container>
-            <Container id="KvpmZg6O1U2qTA-Tr9b8Jw" name="ArterialBlood" description="ArterialBlood" icon="ArterialBlood" mode="Logical" containerType="Organ">
-              <Tags>
-                <Tag value="ArterialBlood" />
-                <Tag value="BloodOrgan" />
-              </Tags>
-              <Children>
-                <Parameter id="1qMchx_wA0eXFt24eHFstQ" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" persistable="0" isFixedValue="0" formula="R-VvYQDydk2AYostLb-_-A" dim="Dimensionless" quantityType="0" />
-                <Parameter id="uceTGobr0kG5lBr2pM8lSA" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" formula="XK5ldnmC9kegT_bYdzctZg" dim="Density" quantityType="0" />
-                <Parameter id="Z1XOYF4lOUGlLrZUWnvKDg" name="Peripheral blood flow fraction" description="Blood flow fraction in organ used for calculation of peripheral venous blood concentrations" persistable="0" isFixedValue="0" formula="vr_qps01MkiEN6bkB5i9kw" dim="Fraction" quantityType="0" />
-                <Parameter id="u6iju4GaDEOkK5wDHR1c9w" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" formula="mkw7cXAseUSaVPXmUe12tg" dim="Dimensionless" quantityType="0" />
-                <DistributedParameter id="ZzPLqhJUGkeRabecWG9IBQ" name="Volume" description="Volume of organ or compartment" persistable="1" isFixedValue="0" formula="BS7z27AxwUuPhK8-5AyNlQ" dim="Volume" quantityType="0" mode="Logical">
-                  <Children>
-                    <Parameter id="3XhRjKAZuUiLxQiVAqkKbA" name="Percentile" persistable="0" isFixedValue="0" formula="i2zen8S_w02faNR54xHUgQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="ieL0vIS_LUe-CyLNRVZSWw" name="Mean" persistable="0" isFixedValue="0" formula="KoCPOQAC-UePgefOZXAhtw" dim="Volume" quantityType="0" />
-                    <Parameter id="NzYZYIrh-U6UPrcIlmdg-g" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" formula="f_dJzAWPaEe5tA47xs_88A" dim="Volume" quantityType="0" />
-                  </Children>
-                </DistributedParameter>
-                <Container id="CcmyB0FGkEKvncpso4EAvQ" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Plasma" />
-                    <Tag value="ArterialBlood" />
-                    <Tag value="BloodOrgan" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="12j2lX7tG06K86tkPko5lw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                    <Parameter id="13q2CS_vo02TzbKGKTtsgQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_pls_BloodOrgan_4Comp" dim="Volume" quantityType="0" />
-                    <Container id="8ix0RRzhxkOPABZfPCvTNA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Tags>
-                        <Tag value="MoleculeProperties" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="dNQYOke_TUK0mBUI5yvW6g" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" dim="Dimensionless" quantityType="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="Q5cCzzKlnke4qkHZ8xor5Q" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="BloodCells" />
-                    <Tag value="ArterialBlood" />
-                    <Tag value="BloodOrgan" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="rLtQpGDLVEKe-jpSrwxFig" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                    <Parameter id="PAv3eMk5X0ajnd_-2XU65Q" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_bc_blood_organ_4comp" dim="Volume" quantityType="0" />
-                    <Container id="IlBZnFur206P8HSZDRQV_w" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Tags>
-                        <Tag value="MoleculeProperties" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="5I-ig2SwM0WTwjmFWeKAKg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" dim="Dimensionless" quantityType="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-              </Children>
-            </Container>
-            <Container id="R3nOYl7_VU62l9QCspJwVA" name="Gallbladder" description="Bile compartment used to collect excretion to the bile" mode="Physical" containerType="Organ">
-              <Tags>
-                <Tag value="Gallbladder" />
-                <Tag value="Liver" />
-              </Tags>
-              <Children>
-                <Parameter id="hBWngz-RekaU3hJ_NjF0nA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="DhZciD-ErUe1rfonkb1aeA" dim="Volume" quantityType="0" />
-                <Parameter id="wAT24WCE10WGTAxMRa6oMQ" name="Gallbladder emptying rate" description="Rate of gallbladder emptying" persistable="0" isFixedValue="0" formula="EisY_ySBB0yLkxe7JgDv4A" dim="Rate" quantityType="0" />
-                <Parameter id="IyYuinRUf0KcAp8_WHgsRg" name="Time to complete gallbladder refilling" description="Time to complete gallbladder refilling" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_GallbladderRefillTime" dim="Time" quantityType="0" />
-                <Parameter id="dfWK7_2f0k-cJfshKLUzaA" name="Gallbladder ejection half-time" description="Gallbladder ejection half-time" persistable="0" isFixedValue="0" formula="IpbnoxwiQ0Ksab043IYNsA" dim="Time" quantityType="0" />
-                <Parameter id="oWjN9RIGoE2xVKdDrlAFJg" name="Gallbladder ejection fraction" description="Gallbladder ejection fraction" persistable="0" isFixedValue="0" formula="lP8kYZ5puEemZrvvDOYldQ" dim="Fraction" quantityType="0" />
-                <Container id="n5AQl_9FEUikNuF70HDCVg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                  <Tags>
-                    <Tag value="MoleculeProperties" />
-                  </Tags>
-                </Container>
-              </Children>
-            </Container>
-            <Container id="_wHsYzyYYUe0jhpQQR0R0g" name="Bone" description="Bone" icon="Bone" mode="Logical" containerType="Organ">
-              <Tags>
-                <Tag value="Bone" />
-                <Tag value="TissueOrgan" />
-              </Tags>
-              <Children>
-                <Parameter id="038hIrEnlkCWZE2y3LiVog" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_Q_from_Qspec" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="tBjKDBuDcUmRsBoecDMkTQ" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" formula="VascularEndoVolume.VOLUME_VascularEndo_bon" dim="Volume" quantityType="0" />
-                <Parameter id="yEAuhr7Ri0-10QIeIzgWbw" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_f_cell" dim="Dimensionless" quantityType="0" />
-                <Parameter id="D0WGYvOF702zxD-F_iGg5Q" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" persistable="0" isFixedValue="0" formula="5OsmFsF4j0elJolEnBNxNQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="_roxIahSZkCcqwWIhf1MEQ" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" formula="e5j0p7OFtUSxWxuq7TDVRg" dim="Density" quantityType="0" />
-                <Parameter id="AZd1i2pVA02KvqDEu23_sQ" name="Peripheral blood flow fraction" description="Blood flow fraction in organ used for calculation of peripheral venous blood concentrations" persistable="0" isFixedValue="0" formula="9rXPDKYmMEOWFLRTqB__IQ" dim="Fraction" quantityType="0" />
-                <Parameter id="wew3DF2yOEqyHaWs-CQY7g" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" formula="QbTqJElu50yRxgafv98O7Q" dim="Dimensionless" quantityType="0" />
-                <Parameter id="LDXDdW_500iu_MKT7feR8A" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" formula="y9WKHH5f4ke89lDFsxo8NA" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="d0PrFEaEXk2n3ybbkNDDoA" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" formula="nMLSMszvdUGYdZ652tFBdw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="n6B5UcPLRUW8wBfuyt8y5A" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" formula="kYcl66AaHkyYqfO6n6Qc8g" dim="Nanolength" quantityType="0" />
-                <Parameter id="5dusnIAdy02IYOtJa7YETw" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" formula="7bDjQ0QwzkWOSqpHx6MjOg" dim="Nanolength" quantityType="0" />
-                <Parameter id="3scEdjh-RkejL4sHGhysUQ" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" formula="fjMRSp4LMUuqGD7_YaoSBA" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="KMFqS7Ee0ECyYw3-bnpbug" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" formula="nmsDa5yAr0aYxU2F0nE31g" dim="HydraulicConductivity" quantityType="0" />
-                <Parameter id="Dv65cuE6CUmf_rDTq4Tovg" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="9woPKW2hO0GzGI_0KHhOsA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="ZWAv2bVYbUCG3aLI5enBoQ" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="p-NRjP1BuE-DjjDanHTWEw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="7Y92TLumEkiY-TbNbganuA" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" formula="zwZJ4Fv6mkyu8i5zSHzjHQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="_wAYEXfn0Uaj-XXSuk_lwg" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="XKPit_H_SUqpkAVXsylcsQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="JPSbYtLjCES-mAMNErAszA" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="Ng2zdcsc8UW1-FFhGT5mew" dim="Dimensionless" quantityType="0" />
-                <Parameter id="GUVrb5CyU0KgUft88-k9jg" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="z0af2QZ4k0yKjdEinZnEQQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="M43xvE3kZkCfpIbIC-OfJA" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="2Q9IOtORbUKgQMJeiUFZ9A" dim="Dimensionless" quantityType="0" />
-                <Parameter id="IrJt2bC60E-AEDzc4OHkFw" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="SuDIw6Ip-kuWtt1_wmvmtg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="a9YXC8ijLkqB29IuFsoNMQ" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="JIflW34iQUirJ7Ru1YSwXw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="3wpqVhjleUKycwq63pT9Bw" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="B78Diz9N5kCxCAymJD1k3w" dim="Dimensionless" quantityType="0" />
-                <Parameter id="936BCKrWpUaSCq_zm_EmLA" name="Microsomal protein mass/g tissue" description="Microsomal protein content per gram tissue" persistable="0" isFixedValue="0" formula="Jb5LLpPgR0uUdUcBMCWWnA" dim="MassProteinPerTissue" quantityType="0" />
-                <Parameter id="rtc2unwpd0y4-NSrocODgA" name="Number of cells/g tissue" description="Number of cells per gram tissue" persistable="0" isFixedValue="0" formula="erTPsTUqPUG7zDSUkOmU8w" dim="CellQuantityPerTissue" quantityType="0" />
-                <Parameter id="PH0MgarfRUWolOrPNbuOsg" name="Protein mass/g tissue" description="Total protein content per gram tissue" persistable="0" isFixedValue="0" formula="5TrvIpjq8EiaJMjLGiz_2A" dim="MassProteinPerTissue" quantityType="0" />
-                <Parameter id="LSSwQ1YrokOOKCOtbLvKRA" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" formula="a0HTvs2qrEm_nAMABKd8yQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="0vHUx-qYYUeItG_tiLd65Q" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="2KCDnogBvUKBFourWDqYsw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="OsWLL2KX6UeGbrwXFyIvOw" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="mzKtgiocz06kFw_o93RYNg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="_WzXpEFlBUWD8oVgoxUeLg" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="G76mPpowbkeI5uxNpq4NHg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="yuLo_D8BKkqbkRVOkJA1kQ" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="U5TP4YvJu0GuZanOZZT0MQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="PqLuXEN4zECNgPHAAiq8Aw" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="tkvTsKLfI020MkniIWMapw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="FbuQyEevLEScPs5N-AaFOg" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="WcJJMvz_H0u_7rtdBvAiWA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="P0SkOxrC5Uqzz2TBYT7gqg" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="R2gRjFqyM0y-LuN7jmsKzQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="cKlBGu8ni0Sy6vDdgr-VnQ" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="eDbmwvydoUix53TLgiZlpQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="Nc0wz3upDEO7521oNMxpOw" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="nVIqB9UIjE6nJGjKW9zHXQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="T9-SYrPYHkqcAiGakEj9Gg" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="PenIff0lo0K-LA2RjBP1Fg" dim="Dimensionless" quantityType="0" />
-                <DistributedParameter id="HCMdxtrZxUChCaL7IQXbPg" name="Specific blood flow rate" description="Blood flow rate normalized to the organ volume" persistable="1" isFixedValue="0" formula="zzigPcprqUy2Io9fY-QCkg" dim="Flow (volume) per organ weight" quantityType="0" mode="Logical">
-                  <Children>
-                    <Parameter id="imlIXzvKt0eFrscRb3ua5w" name="Percentile" persistable="0" isFixedValue="0" formula="WcmkfiE3KkGn0naPXF_Ceg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="K4LNplO8TU6wwl4ab_IbUA" name="Mean" persistable="0" isFixedValue="0" formula="7Zi0UEx9bEK27TYrm6uDiQ" dim="Flow (volume) per organ weight" quantityType="0" />
-                    <Parameter id="s949BIwPK0-aHOkBSCmKyg" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" formula="PfNdTElQikWB-QLwB0tBWA" dim="Flow (volume) per organ weight" quantityType="0" />
-                  </Children>
-                </DistributedParameter>
-                <DistributedParameter id="cOwBZSoigUGgL_rLu6gWgQ" name="Volume" description="Volume of organ or compartment" persistable="1" isFixedValue="0" formula="tNcubZ5pPEqowqUBGo0nlg" dim="Volume" quantityType="0" mode="Logical">
-                  <Children>
-                    <Parameter id="D0d-RuNJmk-Om9YFDQxsMg" name="Percentile" persistable="0" isFixedValue="0" formula="3D874HbdW02nsr38CHM2vw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="jV5gIYNnGk--5HyJmdS00Q" name="Mean" persistable="0" isFixedValue="0" formula="IsDC2kv-LEauIK6bEftwvg" dim="Volume" quantityType="0" />
-                    <Parameter id="uaMOpMkB0UG9GEdYAEdl1w" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" formula="76X6lm-JU0qD1dxxulOdUw" dim="Volume" quantityType="0" />
-                  </Children>
-                </DistributedParameter>
-                <Container id="1QX1qBETMkegE2iTSbuxZw" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Plasma" />
-                    <Tag value="Bone" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="6CY3AYBCQ0-t8gYQrZQm1g" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                    <Parameter id="0lFmtE5N-EaY0rFsjVNs-A" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" dim="Volume" quantityType="0" />
-                    <Container id="juCNrvhbuES2aJnVnaz2Vw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Tags>
-                        <Tag value="MoleculeProperties" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="6kEre5VMaUyNIqYEd14XKw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" dim="Dimensionless" quantityType="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="IdyTRgrwCk2h6V80mW3PDQ" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="BloodCells" />
-                    <Tag value="Bone" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="34xrcsxyZkusLMT1ybaZdQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                    <Parameter id="wIIZFCaQ_U6vF6YrX3D1vw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" dim="Volume" quantityType="0" />
-                    <Container id="jvTfG-isyEuiHjfTFknz0w" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Tags>
-                        <Tag value="MoleculeProperties" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="AY7ZTP05XECQ3PQ1sX8dtA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" dim="Dimensionless" quantityType="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="fVle7EGUPUCUc-_DIn6HPQ" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Interstitial" />
-                    <Tag value="Bone" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="MieaEDfPYkeJCsGHTk3n_w" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                    <Parameter id="yGWqCajPOEu4hlVunne_fg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" dim="Volume" quantityType="0" />
-                    <Parameter id="ViLpx-Zal0aVsCIB326rOw" name="pH" description="pH" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_pH_INT" dim="Dimensionless" quantityType="0" />
-                    <Container id="iNbdR2TxcEKsvnYjqV32vQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Tags>
-                        <Tag value="MoleculeProperties" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="_AUGEXfzME6YYH8bQtVqOQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_bon" dim="Dimensionless" quantityType="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="NjEZJ1GMDEGlYTPRpeO31A" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Intracellular" />
-                    <Tag value="Bone" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="b8VWEj-Fk02ZZehuM0fxUQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" dim="Volume" quantityType="0" />
-                    <Parameter id="Mae4dSgSaE6EN24ylBJCDQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" dim="Volume" quantityType="0" />
-                    <Parameter id="WqmNVTKooUOBFsdiMEB8oA" name="pH" description="pH" persistable="0" isFixedValue="0" formula="VoqonYPdKUCQnZc26yKrFA" dim="Dimensionless" quantityType="0" />
-                    <Container id="ZFgnQf03uEmsiKMVfGP8nQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Tags>
-                        <Tag value="MoleculeProperties" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="t0h1dfTlX0mP1Qgp8nxDEA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_bon" dim="Dimensionless" quantityType="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-              </Children>
-            </Container>
-            <Container id="Vo5xb6EfI0aeRqky84S6vQ" name="Brain" description="Brain" icon="Brain" mode="Logical" containerType="Organ">
-              <Tags>
-                <Tag value="Brain" />
-                <Tag value="TissueOrgan" />
-              </Tags>
-              <Children>
-                <Parameter id="V6nOOCFC90eBS1YDIDUJtA" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" formula="VascularEndoVolume.VOLUME_VascularEndo_brn" dim="Volume" quantityType="0" />
-                <Parameter id="Z5QST8Rh30-6fZ19715Lyw" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_f_cell" dim="Dimensionless" quantityType="0" />
-                <Parameter id="4q8dVhHCw0CvTmRg9m9IXw" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_Q_from_Qspec" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="n5zviY_vm0aIn427Ju7uyA" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" persistable="0" isFixedValue="0" formula="agEZW3LbPE28iVDS8vTTqA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="qngZtXF7XkuNzLg0NZu-vA" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" formula="t-c0S_1_HE21VWjc-LbNKw" dim="Density" quantityType="0" />
-                <Parameter id="3Il12bfII02BbVX-vfKikg" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" formula="_6DUNGJQekeAKl1cDnh8zg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="T0F3RqFlzEqmCvkPOy-kcQ" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" formula="jbHZDdyMAkWwIHJyBRhZug" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="Kyr7gd6OYUSs3J6NMs3fzw" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" formula="cqoyzlYfuEG8g0fOhP32yg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="YxUvIBq4w0OJgJzsBm7lmg" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" formula="K5TEqZ5fN0iFZRBO4frEAw" dim="HydraulicConductivity" quantityType="0" />
-                <Parameter id="ce_NYpLWz0inZKODEiEi7A" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" formula="UPsmw7eH20yrZP5DuR7Gng" dim="Nanolength" quantityType="0" />
-                <Parameter id="8doMVd6RBEu1XgDOMTZiUg" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" formula="oZknFDf9ykOzlIy94vvbIA" dim="Nanolength" quantityType="0" />
-                <Parameter id="suQgIxkOB0ylKVN7eOKxLQ" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" formula="6svr4TNCskWm4Gbq7xJmcQ" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="4ZsOgrDWZ0u_4BCg0jtP3w" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="_xbS6C2ftEaH905s0ePRzg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="_fQpEtQzCU-xSQJgRtQxCw" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="VNISUefirUKDwndSxFaUXQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="2tInu4t3p0ODd1Vzwz7kUw" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" formula="noexEFBmL0iJeZTfZVo0nA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="ZfdLrzsFNkOJ1zemR5vU_w" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="i77EbW0ZM0KtZBAMxSnu5g" dim="Dimensionless" quantityType="0" />
-                <Parameter id="IyuYeP2efUWJ2W0k5QtpHw" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="CO1m2KcwgUWT7w-w7cCbaw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="D5tdsDBu4U-FRNE4V1MnMg" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="HAeC-7UqSUS8qUhi--MsxA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="7BEvf0eFv0KKS2rKQJkIbg" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="YKHQV6WAC0mXxVmHhMjmyw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="tv9RTfjwMESvhBxQfn4skw" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="p8kCjs1-qU-sLgnKBlmVbQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="GXqcj3Y0okuRfeRRixKFiA" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="a1HMTD60dUiW1-09nuaLKg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="Brr7ahv9v0aIyB48f8TXAA" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="CvMkjRZTnE-P_j8tr8Lj-w" dim="Dimensionless" quantityType="0" />
-                <Parameter id="6089P3dtn0201Cg2Nmxnvg" name="Number of cells/g tissue" description="Number of cells per gram tissue" persistable="0" isFixedValue="0" formula="nt0z4XiDKU299x6WNFDUKg" dim="CellQuantityPerTissue" quantityType="0" />
-                <Parameter id="TMpH-9Wc00CTniWKJC0e9A" name="Microsomal protein mass/g tissue" description="Microsomal protein content per gram tissue" persistable="0" isFixedValue="0" formula="UdmVlfb3PUC8dAYHjSxJfg" dim="MassProteinPerTissue" quantityType="0" />
-                <Parameter id="HoINhsx7mUKcooKCHqLUdw" name="Protein mass/g tissue" description="Total protein content per gram tissue" persistable="0" isFixedValue="0" formula="6s_nJrUjoUmpQnq-KzoNNw" dim="MassProteinPerTissue" quantityType="0" />
-                <Parameter id="wz0QNYpQaEaG6YMvlJhMLg" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" formula="9_UH8qCBC0-VeivVcY2OtQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="ZnCawC52vk-MIuvr0ZYZjg" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="tE6H04oJ6EaoHMyiJAekig" dim="Dimensionless" quantityType="0" />
-                <Parameter id="yss_AF3rLU2MIZ2lZT8PrA" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="SGuaZozei0eUyiERXPrj1w" dim="Dimensionless" quantityType="0" />
-                <Parameter id="hmn3HhxO_EypO7-Uvig3fg" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="6cWokcjnI0O3FViS4gPTAA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="OVcogzzcyUOv6vDD_ZEsGg" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="TxuO_wdi1UKEaMNas7ROoA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="zWAJsCi39Ui3-q7zqIocWg" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="QJgKthZll0mFAs5y_eqA8w" dim="Dimensionless" quantityType="0" />
-                <Parameter id="suZC22N6XU-BAYyvXpd4iw" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="8Mm-lsdPFEu2r87npM63Yw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="W75qO6v4JU-t__GiR9QBJQ" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="TZLNtX6sFEW1Q-5otK_Jlg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="204QK23jK0y87ruOHeBU0Q" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="hEDng5qEVUyrpjmAa9orVQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="tiiAW7XzPU6GI0mFw6-61g" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="zV0N-1vggkiO80zrc1tLGQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="yV7Rb2WJYUO6HckyNk00Ag" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="HozQT3nQLES8b7tPE5cJvg" dim="Dimensionless" quantityType="0" />
-                <DistributedParameter id="FFdyTnO_0UCNxiHpjuLXeQ" name="Volume" description="Volume of organ or compartment" persistable="1" isFixedValue="0" formula="W65EI3ZNEkKhnwnO4VpwAw" dim="Volume" quantityType="0" mode="Logical">
-                  <Children>
-                    <Parameter id="a6U4-Ro2BU6tdInhBMd8Dg" name="Percentile" persistable="0" isFixedValue="0" formula="LV15LJgcaE28TZIT61PtUQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="wUnLXBMN8UeaMNcbpC9Bvw" name="Mean" persistable="0" isFixedValue="0" formula="KX6fMv0DAUCvBpIdHGQmKA" dim="Volume" quantityType="0" />
-                    <Parameter id="clOLQW4hEEegPdyezE1VAQ" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" formula="_MjSpmh7x0Wrm5E6HYATDg" dim="Volume" quantityType="0" />
-                  </Children>
-                </DistributedParameter>
-                <DistributedParameter id="x_W9pNPfekCdld5Z3rAgZQ" name="Specific blood flow rate" description="Blood flow rate normalized to the organ volume" persistable="1" isFixedValue="0" formula="XeKwjbLo9U2p1LOrWXVXUg" dim="Flow (volume) per organ weight" quantityType="0" mode="Logical">
-                  <Children>
-                    <Parameter id="JBM1d-lmb06iI7p4RLneKg" name="Percentile" persistable="0" isFixedValue="0" formula="CB12c2m1JEej441Pfqv_2A" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="ZVPV5ZX_0k2OxyXDuJmTwA" name="Mean" persistable="0" isFixedValue="0" formula="3wnboC0D4Eyk-7eC70qVFA" dim="Flow (volume) per organ weight" quantityType="0" />
-                    <Parameter id="LqksKMaHYUS0l59iNFAMJQ" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" formula="ssoA1b9XqkOaVwb2GnyIOQ" dim="Flow (volume) per organ weight" quantityType="0" />
-                  </Children>
-                </DistributedParameter>
-                <Container id="ozvB9jxtHUKYb5zIJ-i0oA" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Plasma" />
-                    <Tag value="Brain" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="dcXlqVSzI0mY0w6r1ZUUEQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                    <Parameter id="3etSdowHrUeakegHWY2BIg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" dim="Volume" quantityType="0" />
-                    <Container id="p75OoBFr9U2hduYWUr-H5Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Tags>
-                        <Tag value="MoleculeProperties" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="4oeB3CM3U02SFtihQx2jKQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" dim="Dimensionless" quantityType="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="LnYylnnd70CKWWLhZ5wiiw" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="BloodCells" />
-                    <Tag value="Brain" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="DoCUIYODwUaV1YsMtgg21A" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                    <Parameter id="4hEPXrtVrkGvpjfcKbt21A" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" dim="Volume" quantityType="0" />
-                    <Container id="-jMhpM-IVUisxCdHp1XfuA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Tags>
-                        <Tag value="MoleculeProperties" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="jhQzFFktv0Kl2y97YNFsPw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" dim="Dimensionless" quantityType="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="OFqosGHD3k6-j26RlBdWAg" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Interstitial" />
-                    <Tag value="Brain" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="6H9QwfypIkSm2jwHPGsaKQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                    <Parameter id="6Rj9HonHiEywtsTr9UxWXw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" dim="Volume" quantityType="0" />
-                    <Parameter id="vCvrEbQ7nkKAzn9YnLkFRg" name="pH" description="pH" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_pH_INT" dim="Dimensionless" quantityType="0" />
-                    <Container id="ZNcs3MXxeUG3ufelefkVQA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Tags>
-                        <Tag value="MoleculeProperties" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="NCKXZuAk_UKj0jIkyB3keg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_brn" dim="Dimensionless" quantityType="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="KCg-1x-QxESKsTdue2PYPQ" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Intracellular" />
-                    <Tag value="Brain" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="D9i4M1z40keSBoFYXglgzQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" dim="Volume" quantityType="0" />
-                    <Parameter id="4Va2tQ77rkyCzyhKwO6fJg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" dim="Volume" quantityType="0" />
-                    <Parameter id="bA9qSfYNDUKHyoLh5R4hcA" name="pH" description="pH" persistable="0" isFixedValue="0" formula="Vij4XLVyiEqLxN1QZpXfKA" dim="Dimensionless" quantityType="0" />
-                    <Container id="2EIPtc23QU63sbg_VvT5Xw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Tags>
-                        <Tag value="MoleculeProperties" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="q_wLytBkpkWAerPInwdEwg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_brn" dim="Dimensionless" quantityType="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-              </Children>
-            </Container>
-            <Container id="9NaHjOdlZkKrVPXt-eHJ_g" name="Fat" description="Fat" icon="Fat" mode="Logical" containerType="Organ">
-              <Tags>
-                <Tag value="Fat" />
-                <Tag value="TissueOrgan" />
-              </Tags>
-              <Children>
-                <Parameter id="1UA924Jb2kKFAwfGRXXF_A" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" formula="VascularEndoVolume.VOLUME_VascularEndo_fat" dim="Volume" quantityType="0" />
-                <Parameter id="E1hz5zABaU-MtSM7ypIAVg" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_f_cell" dim="Dimensionless" quantityType="0" />
-                <Parameter id="2tuTX20Cg0avCTaiSmJA0A" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_Q_from_Qspec" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="ra8b9VE05UWxU7yxpbyqjQ" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" persistable="0" isFixedValue="0" formula="iPZgURI8vEmCN07g-4C0HA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="2r3tVsN7PEGzSY5B9mB-jw" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" formula="mwyla7LcxkmHg0l2wJaqLQ" dim="Density" quantityType="0" />
-                <Parameter id="BOfM2_y_dUO6BlLCAViIBA" name="Peripheral blood flow fraction" description="Blood flow fraction in organ used for calculation of peripheral venous blood concentrations" persistable="0" isFixedValue="0" formula="IWZMpSPjE0KXcAdGGBoy8g" dim="Fraction" quantityType="0" />
-                <Parameter id="VVAIxkk3bEKoHkKti1ytiw" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" formula="GNjB9o4rpUWlB_ZjTaPZdQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="EZGWQlhB706l3UK9f4CtTg" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" formula="EtlLcxhRqU-a3K5REvRkKg" dim="Nanolength" quantityType="0" />
-                <Parameter id="WP3XKiEFyEivsBEkw78-Hw" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" formula="stv7AUzzikOBdFCU-ntLDg" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="GLHHK7dptkykqlJ6SRdYEw" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" formula="ryNlXHauF0ioAvkP2uQBMw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="ALUEA-saeEyeVuqsZ_eLpQ" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" formula="AhLyer8GH0uWJRvLWy0zuQ" dim="Nanolength" quantityType="0" />
-                <Parameter id="yCl0b4aWxkW1lMseM33d4g" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" formula="nyRogNXPAkyWDg1lzIHPrw" dim="HydraulicConductivity" quantityType="0" />
-                <Parameter id="LQ_askk980aiuXWlTUzG7Q" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" formula="NvPtrYoc-ECCZcSedp5QrQ" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="hNzrobZCKkOmSJhgvnOyvQ" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="0RMwiVM6mkaO6is8mJHEuw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="VR-1SIIpiU-EJFkcMtos6A" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="lsZVE_jq60qTm0VH6cgxdA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="7lgFiy3SRk-5BjEKyjc2bg" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" formula="Q_AIK3GkKkKJ5iHe_BUjUQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="XfM91ATSCEGeS05RKr_GLA" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="I2yl5rw4mEWy36rF3L82aQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="rAWkIAGbhkq3zvvxSLffgA" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="AbUitxkA8ESNeWTy2aqeAQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="QCN-9vQH7kamWWseue6Dlw" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="_WRdMFHLMkSkaqp0Rxu_OQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="5iA1d9k5cE-SWnyHSoIsuQ" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="Vdk0ypvH5UmId6Gr0zONtw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="dfylU8bDEk2Tatp5rIIbYg" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="pPmZ3SX5skOMNy0vodCxaQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="IqZK2hzTaUaB8lwqnX63Rg" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="QkS5mpe-U0-5R90M0Q2dVQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="GbabwqcMFUeBsSZnUu_eZw" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="pG6fxpmJ_k6_bBdIA1E5Gw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="fptYqfJBlUiEGe54qk87Ow" name="Number of cells/g tissue" description="Number of cells per gram tissue" persistable="0" isFixedValue="0" formula="lrIcTZI5H0CeRJcVY_CJ5w" dim="CellQuantityPerTissue" quantityType="0" />
-                <Parameter id="YZdJFeyA20iYq4Sh7GZmKg" name="Protein mass/g tissue" description="Total protein content per gram tissue" persistable="0" isFixedValue="0" formula="FElwmNVg2k6_GCmIrdELcQ" dim="MassProteinPerTissue" quantityType="0" />
-                <Parameter id="AA_sgUUITkSUqDfO29XfdA" name="Microsomal protein mass/g tissue" description="Microsomal protein content per gram tissue" persistable="0" isFixedValue="0" formula="7EVC6MmU8kegBNaTpW6I6g" dim="MassProteinPerTissue" quantityType="0" />
-                <Parameter id="_VAZU1af3UyL4c0Ya3Ji2g" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="KKXdFmS_EU64aP_0Gm2JIA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="w48gZqMnT02YvTvQIoPCMA" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="OH5Ww7nKbUeAsrZpkSA4jA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="LxPeKElJLk-h0dp4afMrpw" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="vOPHF_fBCkuPSH_lkmqE8Q" dim="Dimensionless" quantityType="0" />
-                <Parameter id="v4UV2OktB0ScK1wVBSKqfQ" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="uCsEtys8pECfnIk3Dy3M0A" dim="Dimensionless" quantityType="0" />
-                <Parameter id="34WGpAwBuEG6PUn5rGSKSQ" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="dYgrrt3yo0qcjraYJ6uq6Q" dim="Dimensionless" quantityType="0" />
-                <Parameter id="Z0WihovP70i9cE7qaWO9Og" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="KK_F008nvkSRM-u_k6OAtQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="rH79mLMa1066DM41h472mQ" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="cKdTpDVv1EK42-CL0vsBDA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="OKJgetbHUUaY7UyfPzWoFQ" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="ah2FEz4vYkym8tbuKERtOg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="lkE7XxIdw0KxGKqfE5Qbxw" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="i0q1YPAeO0mZ6_nY4ssUFQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="OYlkK1TUw0OwAGTn1ISpCg" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="u1CI5JZDqEyAbsSKzzV9Kw" dim="Dimensionless" quantityType="0" />
-                <DistributedParameter id="iPaZbQhFIUGsUAA0isprRQ" name="Volume fraction lipids scale factor" description="Volume fraction lipids scalefactor" persistable="1" isFixedValue="0" formula="BgZG__xitUiz0xiIJJZB8g" dim="Dimensionless" quantityType="0" mode="Logical">
-                  <Children>
-                    <Parameter id="QauDc2DiAUGAjFox6rN6YQ" name="Percentile" persistable="0" isFixedValue="0" formula="-5IgxAr9c0i52mhv58O_8Q" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="Sq7AflnrXk64aeZJI5TPgg" name="Mean" persistable="0" isFixedValue="0" formula="T8V5w5XYLE2bKHuZx6YhLg" dim="Dimensionless" quantityType="0" />
-                  </Children>
-                </DistributedParameter>
-                <DistributedParameter id="cVrgMCgYRkqRsKAw8nTmYQ" name="Volume fraction water scale factor" description="Volume fraction proteins scalefactor" persistable="1" isFixedValue="0" formula="Ncv4el2EvUuFX8DD4KTZMA" dim="Dimensionless" quantityType="0" mode="Logical">
-                  <Children>
-                    <Parameter id="-4J_OdQXBkCZcn19VGOMWw" name="Percentile" persistable="0" isFixedValue="0" formula="XMQJJVRaMEazSJg9iTiTzQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="tBmkkRPK5kiNe4ercErCPQ" name="Mean" persistable="0" isFixedValue="0" formula="zHTBmjrDxU6gVjyN2Qc26A" dim="Dimensionless" quantityType="0" />
-                  </Children>
-                </DistributedParameter>
-                <DistributedParameter id="SxnFDLD1PkyXHx3ZX7_1gQ" name="Volume" description="Volume of organ or compartment" persistable="1" isFixedValue="0" formula="xCqaltL8z0KqjXQig0PNAw" dim="Volume" quantityType="0" mode="Logical">
-                  <Children>
-                    <Parameter id="tP7v7SBtJ0eaLHnSGfEq-Q" name="Percentile" persistable="0" isFixedValue="0" formula="Goqm9CCfDUaOCXIPVJQjlg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="v9LLC0nkI0ytsaaeXgW0BA" name="Mean" persistable="0" isFixedValue="0" formula="OGdXwjSv00G73EiCFQiIjA" dim="Volume" quantityType="0" />
-                    <Parameter id="HnS2gGhtbEmdYsbbivcMgw" name="GeometricDeviation" description="Geometric standard deviation of LogNormal distribution" persistable="0" isFixedValue="0" formula="dAze_orE8k-OQ1lG1EJ_Qw" dim="Dimensionless" quantityType="0" />
-                  </Children>
-                </DistributedParameter>
-                <DistributedParameter id="RVfqa6ii1kOZSU32rrgvYQ" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="1" isFixedValue="0" formula="uF-LYSdteUukgyPM6HowbQ" dim="Dimensionless" quantityType="0" mode="Logical">
-                  <Children>
-                    <Parameter id="D2_V_00JS0qE_G220sDqHQ" name="Percentile" persistable="0" isFixedValue="0" formula="zk1zVodLnUOjR3SQN1IdtQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="Ol8-Tt3_nEuwzDlAkv3YXw" name="Mean" persistable="0" isFixedValue="0" formula="8OP3UltypkSp67sZ24e8cg" dim="Dimensionless" quantityType="0" />
-                  </Children>
-                </DistributedParameter>
-                <DistributedParameter id="frSuYvPp-0mrhwPCsVs1mA" name="Specific blood flow rate" description="Blood flow rate normalized to the organ volume" persistable="1" isFixedValue="0" formula="-wlIRYqF9kiOWi2yzlcN1w" dim="Flow (volume) per organ weight" quantityType="0" mode="Logical">
-                  <Children>
-                    <Parameter id="xyU1jzJQR0y7U1yXi8zYNA" name="Percentile" persistable="0" isFixedValue="0" formula="EPuySBrrYkm1iHgr6MDsBw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="amifkzAdokGr9J2YSVyoKw" name="Mean" persistable="0" isFixedValue="0" formula="CQiMp4XVKE-qwzRzSW-tEQ" dim="Flow (volume) per organ weight" quantityType="0" />
-                    <Parameter id="iHTf6GYQVUKM70NKNrfggg" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" formula="qqS9xZEp1kKTJAaleWQN8Q" dim="Flow (volume) per organ weight" quantityType="0" />
-                  </Children>
-                </DistributedParameter>
-                <Container id="TB2j7eh8O0ujgR7ZSmvJyQ" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Plasma" />
-                    <Tag value="Fat" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="HgbWqrQCXkWEOco0pNSPXA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                    <Parameter id="D_FGcWaYsUqe1gtcYoLviQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" dim="Volume" quantityType="0" />
-                    <Container id="cMqVxhjs50-6v-MtOdBA-Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Tags>
-                        <Tag value="MoleculeProperties" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="QYs2aHrKFkOVMgyq-TkRMA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" dim="Dimensionless" quantityType="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="_oYSlCwAvEqqYY-nr9vV-A" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="BloodCells" />
-                    <Tag value="Fat" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="QPa5L_WoZ0iaY_lpc4AsBw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                    <Parameter id="VgN0XGYTa0GHhmqf6TQnxQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" dim="Volume" quantityType="0" />
-                    <Container id="1qjvTZYPb02pRSEVOHxWYw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Tags>
-                        <Tag value="MoleculeProperties" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="1_xYqtZfC0uUny2fe6BsyQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" dim="Dimensionless" quantityType="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="M9k4PJfLME653ailMNDypA" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Interstitial" />
-                    <Tag value="Fat" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="OHoKJ8aP1EKxIAr8ItcL1Q" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                    <Parameter id="yk4tPLoBH0WhgBJahLjQFQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" dim="Volume" quantityType="0" />
-                    <Parameter id="j-9n_nMg7EWs5Nhxm4GSNg" name="pH" description="pH" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_pH_INT" dim="Dimensionless" quantityType="0" />
-                    <Container id="3K512R40-EOtIkzYBmfGwA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Tags>
-                        <Tag value="MoleculeProperties" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="0TLfMXZKb0GP56qFm1a-rQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_fat" dim="Dimensionless" quantityType="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="DW5RiC3hLkOsej5WSXn9iA" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Intracellular" />
-                    <Tag value="Fat" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="360YUeTqeUiZErpPoKs2CQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" dim="Volume" quantityType="0" />
-                    <Parameter id="exWrFOQj-EmJVSkTfjyuag" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" dim="Volume" quantityType="0" />
-                    <Parameter id="6P6v0bZR90eNZYVJ9k7qsw" name="pH" description="pH" persistable="0" isFixedValue="0" formula="9b7E4l4X_kSBr352C6EEUg" dim="Dimensionless" quantityType="0" />
-                    <Container id="oMpOFf7pnkmZWJkyekaRgw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Tags>
-                        <Tag value="MoleculeProperties" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="fhAnklNhHEmhQTwXKNfcWQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_fat" dim="Dimensionless" quantityType="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-              </Children>
-            </Container>
-            <Container id="0XnjhezuvU-ZlRVEaUWpMQ" name="Gonads" description="Gonads" icon="Gonads" mode="Logical" containerType="Organ">
-              <Tags>
-                <Tag value="Gonads" />
-                <Tag value="TissueOrgan" />
-              </Tags>
-              <Children>
-                <Parameter id="5snq2VhCjEGrBwTxf5w1Jg" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" formula="VascularEndoVolume.VOLUME_VascularEndo_tes" dim="Volume" quantityType="0" />
-                <Parameter id="eFWpVwR1XEaTxCKh33p53Q" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_f_cell" dim="Dimensionless" quantityType="0" />
-                <Parameter id="BOOnfv8rB0CPGgZGjvNR1A" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_Q_from_Qspec" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="BU8sRTqnCE-xHNnrgWCNyg" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" persistable="0" isFixedValue="0" formula="z3uTYY8FzUKVi5YNwBtLng" dim="Dimensionless" quantityType="0" />
-                <Parameter id="MYQ3XtgEN0-EXGoOYPug-A" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" formula="GAiNXZ-OAEuNkGksalfFMg" dim="Density" quantityType="0" />
-                <Parameter id="_NCafPrdd0yslfXJAACrKQ" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" formula="KnA4I9V__0WmckbZGkq_Mg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="dpfzYlXLWEKNSfGjH4jA2w" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" formula="AItKL3NKFE6rBikzmE6mAw" dim="HydraulicConductivity" quantityType="0" />
-                <Parameter id="vaqZ6NnW-UW1LE51yhvlPA" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" formula="YysrVjS1zUKq5V5j-sd94w" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="EeON9SQ3kkWCX1zuqKI2Hg" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" formula="2qFJccun-E-FV9SNoV8ShA" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="DnPhAOLJeEGv646IGajVBw" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" formula="e0_ms2u9cEuyVpZTMdZ6Bw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="TybxiwRupUuAZfGSY3q6qg" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" formula="n2g_SFHtNUSSF9W9imuYiA" dim="Nanolength" quantityType="0" />
-                <Parameter id="uM3W9q1AuU-f9PSsFs8JCw" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" formula="1Hd4cvpciE2cao082vtldQ" dim="Nanolength" quantityType="0" />
-                <Parameter id="UK2HwS5HXEWM4I3fnQXDRQ" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="G_vceYgHlEm0f2ANLencNg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="GFWMMpC23U6jQ4xa-M29-g" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="KYYGIyW350uM9VN1_M6oiw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="zq1iD3Yb1UuVtP6wN2anEg" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" formula="ONgpKLJneE6mUe7ngwVwYA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="7SfLoraZJk-meTVlrSiT5A" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="E3alMD9GGkqlVGECrRzIEg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="kPdsm5eJL06z3bu0zgn23Q" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="DX_0Iu_wDkK9LxvkYfJjAQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="pr_Ywgi0AU6cXhRvfDWbmw" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="f3LIP6q3rkSUIuNoWCuj3g" dim="Dimensionless" quantityType="0" />
-                <Parameter id="pJxhJ7WMWk--HWyhzd23-Q" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="NvE8JkdZs0q1wdkSXAdSNw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="UDrJ-LLkQUiTx0FO5Ofqsg" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="nfL7N63uC0C_48SwNMstZw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="XJoIgAkcoU6VYNo7W_aDvg" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="nPE83spU-U2OYQij4la0tw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="VxQ1v8SXakGJ6b5Anb6wow" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="BNP65DyPF0yhH9nsxYliVA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="oG7aJlMlN0qfnZYslzNfvQ" name="Number of cells/g tissue" description="Number of cells per gram tissue" persistable="0" isFixedValue="0" formula="7cTMoSrGZkeh2yEVHLry1w" dim="CellQuantityPerTissue" quantityType="0" />
-                <Parameter id="cm7hakpOtEmiWF3t07MJAA" name="Protein mass/g tissue" description="Total protein content per gram tissue" persistable="0" isFixedValue="0" formula="yCyTjwTyVkOzngPMEFxDvQ" dim="MassProteinPerTissue" quantityType="0" />
-                <Parameter id="HBGCXWtdqkSGCocKDHwUtA" name="Microsomal protein mass/g tissue" description="Microsomal protein content per gram tissue" persistable="0" isFixedValue="0" formula="4CIGC5GtPUuuq9zxddlaBQ" dim="MassProteinPerTissue" quantityType="0" />
-                <Parameter id="KkzvT0kinE-QyNa7DCSkVw" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" formula="maFW_dE2R0WoGiyrJj3hcA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="7ONeuoaBHk61Ab0iygkIcw" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="LGTpiN6Oq06M0obrV0s02Q" dim="Dimensionless" quantityType="0" />
-                <Parameter id="GeAmQyL-q06tMDHfXWH34w" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="x-j2VLmDOkC8kmxs9BgEmA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="im_L_2qGS0uEFYEwUy-HWA" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="XwgMvkgGY0yArFyo-r0dpw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="Ku7xNXlYvUWTe6NVx--HsA" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="ZxEASzjbGEWj8Br9V9uENA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="ce8HgTOtiUSTlNwbYw6g3g" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="AZoScJItMUS6YOWMbGuQuA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="J3ISzk6gKE28HA21YIRG7g" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="RnQHMKneY0OLCRCpWqmsAQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="1PsTHMzkhkuQClvcWAd_Cg" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="bKHOtN42s02y484eBjp6Pw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="1DpV21uI_EmfPyjJOkVB5w" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="FBXpesHXF02wlwgfxZYiZw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="AIzzyjaM9EyFc5Dv3Bx3gw" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="B_MmpflHLES1KxdYwAt4Sw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="5zkCKmiYLUWobJ7_rWQj_Q" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="5tz-kK66aUWImkDb_YrHwg" dim="Dimensionless" quantityType="0" />
-                <DistributedParameter id="-WvKh_iZCUepmg12fPkbBg" name="Volume" description="Volume of organ or compartment" persistable="1" isFixedValue="0" formula="G0GJLL5_SUGksjfIw4f16w" dim="Volume" quantityType="0" mode="Logical">
-                  <Children>
-                    <Parameter id="9v50SONRTESXTDjro4F86Q" name="Percentile" persistable="0" isFixedValue="0" formula="rTM_UgNbq0iIdMD9205e9A" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="QAFRc_GL8EyJj4lBkIvgCg" name="Mean" persistable="0" isFixedValue="0" formula="nnS32mIX7EqMfdLVgjJa5g" dim="Volume" quantityType="0" />
-                    <Parameter id="34tm5sbcvECTryGsHnN7zQ" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" formula="jwBqkN1oOU-liEQ9i_3fgQ" dim="Volume" quantityType="0" />
-                  </Children>
-                </DistributedParameter>
-                <DistributedParameter id="ZNr_Z8pQBUGgxnT_UnEHtw" name="Specific blood flow rate" description="Blood flow rate normalized to the organ volume" persistable="1" isFixedValue="0" formula="WFL89_nUSUC6ftowZx_bPQ" dim="Flow (volume) per organ weight" quantityType="0" mode="Logical">
-                  <Children>
-                    <Parameter id="jh4yMJ5YR0aRKucWSHMhFg" name="Percentile" persistable="0" isFixedValue="0" formula="b7iTxQXeKEK5hfMljdwOZQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="8vZ9AiSCa0GpjnGPPuFDhA" name="Mean" persistable="0" isFixedValue="0" formula="ar3xCU7Zf0SyJ5IyEULlIg" dim="Flow (volume) per organ weight" quantityType="0" />
-                    <Parameter id="8O53h3bx_kS6ePFBA5lGcQ" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" formula="gGZlzSYbhE6gvlNabE04GA" dim="Flow (volume) per organ weight" quantityType="0" />
-                  </Children>
-                </DistributedParameter>
-                <Container id="P1zi7RPUsk27LJ1SfhYvgw" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Plasma" />
-                    <Tag value="Gonads" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="qENbM1wclE-2tVhPsQB1Kw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                    <Parameter id="22gpBMo_Jkm3z5mHtl0wJg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" dim="Volume" quantityType="0" />
-                    <Container id="z-yFSilke0q35t7KL16Wdw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Tags>
-                        <Tag value="MoleculeProperties" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="2KchSvHX7UiVcf1pOHHNKA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" dim="Dimensionless" quantityType="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="eaIswCZLm0uzQT4GU7uRVA" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="BloodCells" />
-                    <Tag value="Gonads" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="pI0XGjgDXEudAf3I2xPuGQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                    <Parameter id="qLTvNoMIYUiLHA3jYj_Duw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" dim="Volume" quantityType="0" />
-                    <Container id="xN4hg_x1mUCxSQD6FLp4jg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Tags>
-                        <Tag value="MoleculeProperties" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="knywDIwM20-sVnosMEqkiw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" dim="Dimensionless" quantityType="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="ewqB_sVllUqKRrHxiVkMsg" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Interstitial" />
-                    <Tag value="Gonads" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="nLYVQhr77EGw4WL6JPPByA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                    <Parameter id="INExtY2fyUWIL2dHNZnOuQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" dim="Volume" quantityType="0" />
-                    <Parameter id="f38qBwiRdkSYeJjPRK2zlA" name="pH" description="pH" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_pH_INT" dim="Dimensionless" quantityType="0" />
-                    <Container id="EBf90TpxlkWJEQZe-y7qBQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Tags>
-                        <Tag value="MoleculeProperties" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="yMmhci1cd0m-jnhH_jQeVg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_tes" dim="Dimensionless" quantityType="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="mvPEUvCjjE2amGVxx_avJA" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Intracellular" />
-                    <Tag value="Gonads" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="kXCg_jHDvUmNG5KXuNOvqw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" dim="Volume" quantityType="0" />
-                    <Parameter id="SWm2SzuL9UiDzI-molNKkg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" dim="Volume" quantityType="0" />
-                    <Parameter id="fs62qVCynEGnGQy4JEBO3w" name="pH" description="pH" persistable="0" isFixedValue="0" formula="2NMyGLzS4EyhkpL_q6rQFA" dim="Dimensionless" quantityType="0" />
-                    <Container id="Y0u2ZNOQhkq63iYml1hsBA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Tags>
-                        <Tag value="MoleculeProperties" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="QfqQZKTQXUmVCX35Wg-mmA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_tes" dim="Dimensionless" quantityType="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-              </Children>
-            </Container>
-            <Container id="-XoxXu70P0-OZznvtsb84Q" name="Heart" description="Heart" icon="Heart" mode="Logical" containerType="Organ">
-              <Tags>
-                <Tag value="Heart" />
-                <Tag value="TissueOrgan" />
-              </Tags>
-              <Children>
-                <Parameter id="DrDmEgYECUSXc70QytSnqQ" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" formula="VascularEndoVolume.VOLUME_VascularEndo_hrt" dim="Volume" quantityType="0" />
-                <Parameter id="wQX4LDlD5kScusHbcyKxBw" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_f_cell" dim="Dimensionless" quantityType="0" />
-                <Parameter id="wMiLz9ykYkezjkfAVEfZpA" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_Q_from_Qspec" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="zPUkFEchO0K8mSslYgJ4Uw" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" persistable="0" isFixedValue="0" formula="NqsBzguwWEuS6Kngc8_F0g" dim="Dimensionless" quantityType="0" />
-                <Parameter id="omsksZ0S70eAmPsAWg020g" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" formula="f27F8xcdgEWY__2lmlW2Zg" dim="Density" quantityType="0" />
-                <Parameter id="4iSBc_jdN0KOLWCjzl5QCw" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" formula="b9FIpBSC_EOrC8SwTFLuSQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="4Wz3VDsIdEWTlfQPM9GASw" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" formula="kaW_jcYd7Em43UsZ88sHCg" dim="Nanolength" quantityType="0" />
-                <Parameter id="gMEBV8Lp4Eaec701lRVlGw" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" formula="k6JnxzyTm0yieAUnRihnUA" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="8T7-_wc0JEGLxA5qmSmWQw" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" formula="9vjJY2VXAEq3RyrI6lNNSw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="zOYekBect0q5BYS2ADGw1A" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" formula="_kCtdXMmF0Kg_PVub4lfPw" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="wDN6e6_McUG8GA2CKBzdMQ" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" formula="xaG4GHs1rkukHH8xYXMiOA" dim="HydraulicConductivity" quantityType="0" />
-                <Parameter id="HsTFRrrV1kKkZUoTWatswQ" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" formula="LlOi15vxy0y7UplV1w6kTQ" dim="Nanolength" quantityType="0" />
-                <Parameter id="XFlatpDYsk6ji6830DPXzA" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="XnrgLLkFIUmunk5PmPCscw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="33dRTCHGkUyj5xfiWz-iTA" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="443CB60qok6nCGHEoV2lsw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="Gkmp3A9QXUq-CNyl53DcDg" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" formula="gC2oURWxy0eNVMlzdqQhxQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="fKfisoYbP0G_eK9IivbjrQ" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="EVPu-iCSmUiEKzWEnRx5Vw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="nJPu5yhhQ0GPffZSKSMq_g" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="aKw3W9E2NEmVnSU8uO9orQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="FPO24gKXmECchSBswoHOUw" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="k9uh8oCuPkWIB5YwSREnEw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="tahDaFEfN0Kd6KcFU7RQgg" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="bbxwon-E6EGRbWtHMrEP-A" dim="Dimensionless" quantityType="0" />
-                <Parameter id="21LeLzFHqU-tjnKccSGgiw" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="19yhsPxH2UqBVhH4yuwYyg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="5y4yM09O2UuDFGSh9MdYwg" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="mxJgfRr-WkGsl9mn5pkrxw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="1P4Nzf2ldECckks49X00Eg" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="UuZVfkwHgkOkEShPAsZtHQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="GCfJtKWzCk2iC27nxzcaTw" name="Microsomal protein mass/g tissue" description="Microsomal protein content per gram tissue" persistable="0" isFixedValue="0" formula="o5BsqhAyUkuGAK_JOCpPaQ" dim="MassProteinPerTissue" quantityType="0" />
-                <Parameter id="ETBNIiH240uAN-_NRpjusg" name="Protein mass/g tissue" description="Total protein content per gram tissue" persistable="0" isFixedValue="0" formula="5bpdev4lr0ajOB_LuScr_g" dim="MassProteinPerTissue" quantityType="0" />
-                <Parameter id="sXpTg86ba0ScTO9aCTR6Gg" name="Number of cells/g tissue" description="Number of cells per gram tissue" persistable="0" isFixedValue="0" formula="d9wQ3kNigEWw59yVo57tng" dim="CellQuantityPerTissue" quantityType="0" />
-                <Parameter id="w2tNitaOKUmezW68HrUJWA" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" formula="YyONqckv-Uufw2TMQIRjdg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="SlfoXK2oiEiWzaKOVrAZoQ" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="9Ij9FZTA2Ey57UvbEczvLA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="9PuaXLzm9kyh6HgdtK4m5w" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="ZLoWw_RSY0ucJekLuTzQHA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="YO91AMMvRE2Ss21CeNw8aA" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="UkE_h7cIMkGd-IWM2rCbWg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="V-MH3dDRyE-WVkYuGS0Mig" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="AyU4WEsjLE-uPX5FW-7Few" dim="Dimensionless" quantityType="0" />
-                <Parameter id="6eT2xwRR8EeZHGHzoqOtJw" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="FRD8jcIQT0CjiKmpY71Zgg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="ZqUZCqo4_Eaff5K69-sp3A" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="sLwQSjbZsU-VGx1w2uBh6Q" dim="Dimensionless" quantityType="0" />
-                <Parameter id="ogNAgql67UKog2Y-HZ55Og" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="pk0ok5p040yfUPVU6PO9iQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="GJFn1NM0mkeSBJPB9bTOcw" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="tz3N5CwaVES1ANx4yeZegw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="-E6TXoQD5Uypo5ZQ_r9kzg" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="jiHrmrrMqUuJ0L3yH71PoA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="IrFYo0UKjkSpZGPisF0W7w" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="uJ_-9ECydUy5b4l49yde8Q" dim="Dimensionless" quantityType="0" />
-                <DistributedParameter id="LNm2pxz3W0aMn321mz0Ffg" name="Volume" description="Volume of organ or compartment" persistable="1" isFixedValue="0" formula="quKam-CNrESHnyOWpYBxDA" dim="Volume" quantityType="0" mode="Logical">
-                  <Children>
-                    <Parameter id="z4nWTlKsCEawTq6Pv4fXPA" name="Percentile" persistable="0" isFixedValue="0" formula="2umQIXUw9ECPEVanca2u0Q" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="Op2bx8hvFk6VkHmiEVZfRw" name="Mean" persistable="0" isFixedValue="0" formula="a1H3WE3v9Em4KRRywGsPdQ" dim="Volume" quantityType="0" />
-                    <Parameter id="vbyGvVaCVEC-51BwqDI1Ow" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" formula="ihKDgM_hskGyonO3Qc__Jw" dim="Volume" quantityType="0" />
-                  </Children>
-                </DistributedParameter>
-                <DistributedParameter id="N6jXep8vY0i-KVl3NB3M1w" name="Specific blood flow rate" description="Blood flow rate normalized to the organ volume" persistable="1" isFixedValue="0" formula="-ERxkZbrHkeuZxcd-C7oSg" dim="Flow (volume) per organ weight" quantityType="0" mode="Logical">
-                  <Children>
-                    <Parameter id="FSKLFr0UnEG-c7-r7B_5Tg" name="Percentile" persistable="0" isFixedValue="0" formula="4H4b3nyjVEyxjPOUrvI9dg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="vi7Or-bQKECc6P5Oa5cC8w" name="Mean" persistable="0" isFixedValue="0" formula="jg58xcfBHEWl7ZQ-h5GhgQ" dim="Flow (volume) per organ weight" quantityType="0" />
-                    <Parameter id="7nUWwmd7bEmIRo91BnsrKg" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" formula="HtkuivPGGUuM-pzpmf8AgA" dim="Flow (volume) per organ weight" quantityType="0" />
-                  </Children>
-                </DistributedParameter>
-                <Container id="XAQdPJN_Z02jzlcPJL4q9Q" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Plasma" />
-                    <Tag value="Heart" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="FJq5JE8K60q13268hEOHtg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                    <Parameter id="OUG3ZcBRK0-lDXlzldZAmg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" dim="Volume" quantityType="0" />
-                    <Container id="nyzTN5BI3EiA-5e3rueHUg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Tags>
-                        <Tag value="MoleculeProperties" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="w6rIgUBCDEOwM4lZzjYhgg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" dim="Dimensionless" quantityType="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="6CFlcb_lrU6luBMQ8jh8fg" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="BloodCells" />
-                    <Tag value="Heart" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="_L0KMi8VeEOT9_3Muhlfgg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                    <Parameter id="xsJqB76uUEyS3-l-Tft-4Q" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" dim="Volume" quantityType="0" />
-                    <Container id="BnCxcFeuF0-pXDJhSHMd1Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Tags>
-                        <Tag value="MoleculeProperties" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="jXx0VZ0Gski7NDxLVN5hcA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" dim="Dimensionless" quantityType="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="I7bINaSuD0WzKUqQQL0fGw" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Interstitial" />
-                    <Tag value="Heart" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="Kv-VJZq9Rk6D-LzTLH1o4g" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                    <Parameter id="l3pcFx0c-0ilA5-IbwOuEw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" dim="Volume" quantityType="0" />
-                    <Parameter id="DxyHaMoE5EGXv3tZR1_0xQ" name="pH" description="pH" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_pH_INT" dim="Dimensionless" quantityType="0" />
-                    <Container id="hD87u2vuTkSGl7JC6I6eEQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Tags>
-                        <Tag value="MoleculeProperties" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="ov-_KTiuU0epV2chnaYQBw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_hrt" dim="Dimensionless" quantityType="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="FmqZSzKh90W-2a_HA6avrw" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Intracellular" />
-                    <Tag value="Heart" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="hTjYt2vTXECSkeaIWkj4ew" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" dim="Volume" quantityType="0" />
-                    <Parameter id="rkVzmUbKQEmolQnbuaNtaA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" dim="Volume" quantityType="0" />
-                    <Parameter id="OMxbmstvYU6WQzDNEIBBEA" name="pH" description="pH" persistable="0" isFixedValue="0" formula="PatA1X5G6UOoh4LAxJjd9Q" dim="Dimensionless" quantityType="0" />
-                    <Container id="KswwFfCqI063Mv85j9pXMg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Tags>
-                        <Tag value="MoleculeProperties" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="hDtyvervmU20NaWjZiQA9A" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_hrt" dim="Dimensionless" quantityType="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-              </Children>
-            </Container>
-            <Container id="utE_a8v-I0WENNeQSLmbZA" name="Kidney" description="Kidney" icon="Kidney" mode="Logical" containerType="Organ">
-              <Tags>
-                <Tag value="Kidney" />
-                <Tag value="TissueOrgan" />
-              </Tags>
-              <Children>
-                <Parameter id="pZ22O9Pn_kqVAGZwzbgEHQ" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" formula="VascularEndoVolume.VOLUME_VascularEndo_kid" dim="Volume" quantityType="0" />
-                <Parameter id="s-9bD9OruEmF10AOflZGqA" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_f_cell" dim="Dimensionless" quantityType="0" />
-                <Parameter id="G2qug2IVcEqUZvlQaU54Fg" name="GFR (specific)" description="Glomerular filtration rate normalized to the volume of the kidney" persistable="0" isFixedValue="0" formula="GFR_Calculation.PARAM_GFR_Spec" dim="Flow (volume) per organ weight" quantityType="0" />
-                <Parameter id="-gEZpe36bkOFWzstsTj25w" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_Q_from_Qspec" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="0962DmnNwkuo-snTOPh_eQ" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" persistable="0" isFixedValue="0" formula="sV4SKCIk-UiwE34KaVEoWg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="JXSnBFyeEUmh26NIJVK7tw" name="Volume (standard kidney)" description="Volume (standard kidney)" persistable="0" isFixedValue="0" formula="ukYcQodGcUaqwnIGrUT3rA" dim="Volume" quantityType="0" />
-                <Parameter id="ZqzKaVOwx0OZfHjib4udZg" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" formula="AkAfqFgOckiAh-MYNBR7xA" dim="Density" quantityType="0" />
-                <Parameter id="jtmbhN95rEG7FXlYHESXeA" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" formula="1bJWaBSmmEiz9f5k8pgaeQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="PxqDEIgOR0Ss7xyFS9pESw" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" formula="3gNtvvTsJUC8t-mvC93qdw" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="bAEibdBrO02qXVIFF6l39w" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" formula="hkw6pktfxUmzIRc6nrXz3w" dim="HydraulicConductivity" quantityType="0" />
-                <Parameter id="zXLNPfDGcEKoZJoOKhokHA" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" formula="aeW0zPkvk0mKSTjqjm168A" dim="Dimensionless" quantityType="0" />
-                <Parameter id="FLTG7YrVukC3Cs-YVVl0BA" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" formula="ptu1vg-4V0Wa3LQ10sRF1A" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="SMge-ohoHEetKNyQJzaysg" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" formula="6kppqxI0oUSrg4uQUP177A" dim="Nanolength" quantityType="0" />
-                <Parameter id="_rnU1gre9E2vOjir7C02gA" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" formula="PH403K66KUqeVhhHuScFcQ" dim="Nanolength" quantityType="0" />
-                <Parameter id="NSuH_HDIs0iy12uyCTnyog" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="DJVJYCCHGEyLbf59VAqbKg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="J5FUcTpV30-QIvkJJC_-QA" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="NG8Nxv7q2E-uSusobWh8Ig" dim="Dimensionless" quantityType="0" />
-                <Parameter id="PYYlhAUxxEWnT5Ai1bPnJw" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" formula="rooRjltQg0G4XY586XzI4Q" dim="Dimensionless" quantityType="0" />
-                <Parameter id="KFduMF3AIEmOC10_085hkw" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="N970JTUiAkGtakg3JZMEAw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="wcPE2ms16ECHO9RM38LQxw" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="5qcZ3xYkJ02vOU78GE5v2A" dim="Dimensionless" quantityType="0" />
-                <Parameter id="heHyrorQC0-v8rOUjJLbwQ" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="W0ZjUwE8GUeg2oSUPGlYuw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="ohMsd7-bekyvrcX6Kcr7BA" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="sqkTYZvtjUysMMYygTldoA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="v0I16RLNRkqjp4HD5UCgzw" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="NtNDLM6Z-kOn0w9LFyI-ow" dim="Dimensionless" quantityType="0" />
-                <Parameter id="LWGSRtBv5kmHOTdNn4RSLg" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="eN7u67UI9UOxWmkJXjHzZg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="mjaEIJpHLEG3uerWOZRQxA" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="2zotKY0oZ0CWhoZF-vRNUQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="BvJFJtn_AEG6R3yoX4U70Q" name="Number of cells/g tissue" description="Number of cells per gram tissue" persistable="0" isFixedValue="0" formula="tx6C2TPxxEWwcKhigSlBAA" dim="CellQuantityPerTissue" quantityType="0" />
-                <Parameter id="yDRW4V-rKUKKgVRHgy0xug" name="Protein mass/g tissue" description="Total protein content per gram tissue" persistable="0" isFixedValue="0" formula="6pseLTxeKkebEH2h_hskRQ" dim="MassProteinPerTissue" quantityType="0" />
-                <Parameter id="zrVYV_V7UEWYfur5i8NfZg" name="Microsomal protein mass/g tissue" description="Microsomal protein content per gram tissue" persistable="0" isFixedValue="0" formula="XSymVImv6Ua61gDb1g_Pzw" dim="MassProteinPerTissue" quantityType="0" />
-                <Parameter id="MbyZMwFdS0u2XF61W1o_Gw" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" formula="GGqb_3C_b0erxEv53oON-A" dim="Dimensionless" quantityType="0" />
-                <Parameter id="hQFjH5-XckykPSiop_4LYg" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="hg7hDNC7k0a7enODRlMLYQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="oJg5cIEwX0CxNXLNOU5cPA" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="Uq60h1wHq0Oudjs0Wgxang" dim="Dimensionless" quantityType="0" />
-                <Parameter id="flZvkSwApUO5vBjqGa-40Q" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="Iy01U2i32US2I4Gem7XPOw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="JFZvOncmBUCqTtG4td5wjg" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="4YSRM9YYD0-ihtxYKqBZtw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="dGufsh_Z5k2cxnf-dYsnog" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="LmlJM-2SXE2Qf4ybTuQI7A" dim="Dimensionless" quantityType="0" />
-                <Parameter id="G9XficNV90a4BSbDTaEoqA" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="7bq65-9LfE-j2tLBmvw4mw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="IerweM2uGEetbic4TaUgEQ" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="lpK0GsbTM0elSQeDnj7f1A" dim="Dimensionless" quantityType="0" />
-                <Parameter id="xzxb5gien0m8CL3rf5JaOQ" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="kVIsp_Cep0OSXMxKcqTBEA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="3F22cnM3b0-rAJY4bU7x5Q" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="HxOvLjnCqE67yA4iQ-Vc9w" dim="Dimensionless" quantityType="0" />
-                <Parameter id="Pxkw8OHTpU6XngfCRVf2Nw" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="fPBI9jb8M0e73O1mPUre3A" dim="Dimensionless" quantityType="0" />
-                <Parameter id="luExsddpKkS7HKUxViMIpw" name="fGFRpremat" description="Fractional offset in the GFR that corrects for a tendency to slightly underestimate the observed median GFR values in preterm infants below approximately 32 weeks of gestation" persistable="0" isFixedValue="0" formula="PrS3PJVEgUiN1RdmnjAVLg" dim="Dimensionless" quantityType="0" />
-                <DistributedParameter id="nfEHYziHS0qTLY4EXhxjBQ" name="Volume" description="Volume of organ or compartment" persistable="1" isFixedValue="0" formula="HFwQ3e0nBUun3kn8c_XyCw" dim="Volume" quantityType="0" mode="Logical">
-                  <Children>
-                    <Parameter id="OICBQYOFsUqXKiioG105fQ" name="Percentile" persistable="0" isFixedValue="0" formula="ZH-ZJxxZp0SZ_Cj4N-zJ1w" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="TyniDebTAUuE76pShXSwmw" name="Mean" persistable="0" isFixedValue="0" formula="NTjy6jG-2U6GiBO3cTxiLw" dim="Volume" quantityType="0" />
-                    <Parameter id="vTdXRxK-B0CkJ96dVDr0Sw" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" formula="dL4kSilhmUGSXhZtmZ3zAQ" dim="Volume" quantityType="0" />
-                  </Children>
-                </DistributedParameter>
-                <DistributedParameter id="BJ0j1Ur63UuoXZlYDm-OLQ" name="TM50 for GFR" description="TM50 for GFR calculation" persistable="1" isFixedValue="0" formula="G4JaJT8xakGABWXPpGrzsQ" dim="AgeInWeeks" quantityType="0" mode="Logical">
-                  <Children>
-                    <Parameter id="zcy9yK_tdUme6K_eaOpQwQ" name="Percentile" persistable="0" isFixedValue="0" formula="8tWHR2yP00-0-gB2m_3I0w" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="GZjk4HXvtUi84mQUlXZGOw" name="Mean" persistable="0" isFixedValue="0" formula="-5EOfz7_f0Gh3t_N6YCJ0w" dim="AgeInWeeks" quantityType="0" />
-                    <Parameter id="vMZwOY-17E-DCQ3jw6lflQ" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" formula="OPVM1ejSNUqNmk4V18PuLg" dim="AgeInWeeks" quantityType="0" />
-                  </Children>
-                </DistributedParameter>
-                <DistributedParameter id="YrUN9Ebu60uDQXkw-ozWeA" name="Hill coefficient for GFR" description="Hill coefficient for GFR calculation" persistable="1" isFixedValue="0" formula="3pulc2VtI0CXsUA6H3kh0g" dim="Dimensionless" quantityType="0" mode="Logical">
-                  <Children>
-                    <Parameter id="eZqCBilNiUKQEirXjWyPng" name="Percentile" persistable="0" isFixedValue="0" formula="rDwJn0nKAUWWxXWfVMuquw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="hCAGc_lTxEaF3y522V7uYw" name="Mean" persistable="0" isFixedValue="0" formula="pIhnQrGNn0yZ-hmnBM-wqg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="DNfuvojw80ybn15XCg64zw" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" formula="RN08RTSZq0CCNooIH8k0Qw" dim="Dimensionless" quantityType="0" />
-                  </Children>
-                </DistributedParameter>
-                <DistributedParameter id="7Fre3-ikbkSzTuzEAUykgQ" name="GFRmat" description="Mature value for GFR in a healthy adult individual weighing 70 kg (=117 mL/min)" persistable="1" isFixedValue="0" formula="XI5g5PaerkysdWFYvUohBA" dim="Flow (volume)" quantityType="0" mode="Logical">
-                  <Children>
-                    <Parameter id="bQkV-0k1ZUW2GQjFy7xjVQ" name="Percentile" persistable="0" isFixedValue="0" formula="5bNXw43E7U2CJ-wgrte_zA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="d1Sg2GtXnEan3PdcFrAyCg" name="Mean" persistable="0" isFixedValue="0" formula="X6ix2YZM7kema5N1r_DSEA" dim="Flow (volume)" quantityType="0" />
-                    <Parameter id="0LXy7jEAkkC0FXjHSoY_sg" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" formula="I0BUwUZ6hU2IwPClP1RmyA" dim="Flow (volume)" quantityType="0" />
-                  </Children>
-                </DistributedParameter>
-                <DistributedParameter id="ISS3y_V2AEKOQvN3Rg8ydQ" name="Specific blood flow rate" description="Blood flow rate normalized to the organ volume" persistable="1" isFixedValue="0" formula="wf6TMQ8sbkWuo5vh811LRw" dim="Flow (volume) per organ weight" quantityType="0" mode="Logical">
-                  <Children>
-                    <Parameter id="rBFaHWpUHEGU-WKh6GQrJw" name="Percentile" persistable="0" isFixedValue="0" formula="XitXASbATUisIHugSEfzgA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="teyTaugtlkedjxVLOuZnOQ" name="Mean" persistable="0" isFixedValue="0" formula="2qJXxoZvSEmnH-QH86G6lw" dim="Flow (volume) per organ weight" quantityType="0" />
-                    <Parameter id="dcl0oKlptkeioR8QomYyWg" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" formula="k1yQ89heF0CWPZtCHPJTTA" dim="Flow (volume) per organ weight" quantityType="0" />
-                  </Children>
-                </DistributedParameter>
-                <Container id="GMY3DO0pi0WpPr2z2G0OmQ" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Plasma" />
-                    <Tag value="Kidney" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="xdqhpXxxcUqiLbzkUpJ_Dw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                    <Parameter id="liiHvBkOlk-P3SIDORLvCQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" dim="Volume" quantityType="0" />
-                    <Container id="Ch6HgWM0dEisqUQR6jycLw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Tags>
-                        <Tag value="MoleculeProperties" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="va_x4WyCVkavytgTphbH0g" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" dim="Dimensionless" quantityType="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="t7OB_yOuqEKWnXRIgdzF5w" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="BloodCells" />
-                    <Tag value="Kidney" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="VL58sWjuPEuXZPXKKmGsHQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                    <Parameter id="2rOcgZ5RIk-y6EYyPPt70g" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" dim="Volume" quantityType="0" />
-                    <Container id="eyVKBY52FEOU2yWFVid0Xw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Tags>
-                        <Tag value="MoleculeProperties" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="CkFmgx0_cka9iCWd8ZPZgw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" dim="Dimensionless" quantityType="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="bradPcqe70-hKncU74RHjw" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Interstitial" />
-                    <Tag value="Kidney" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="KTBk9cYYck2rTYt9dtrp1Q" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                    <Parameter id="OzVQ9o3Owkasm3fxoQ18lQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" dim="Volume" quantityType="0" />
-                    <Parameter id="6USdVeNz1Uumy4jOi6cogw" name="pH" description="pH" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_pH_INT" dim="Dimensionless" quantityType="0" />
-                    <Container id="NZjNT1k0oEeo874jU5GvkA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Tags>
-                        <Tag value="MoleculeProperties" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="jYvRb86EPUOD4a0bJ-sDCg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_kid" dim="Dimensionless" quantityType="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="awyUty3Xo0q15yG3VtdgPw" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Intracellular" />
-                    <Tag value="Kidney" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="ejd8V0XQeEazhmcVxIm7xA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" dim="Volume" quantityType="0" />
-                    <Parameter id="SVrDHnt360uA4HvMxWesHQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" dim="Volume" quantityType="0" />
-                    <Parameter id="aL51WmRM60K90cGhwZKIIg" name="pH" description="pH" persistable="0" isFixedValue="0" formula="5aVcVBa2JkG04cWaE2yxOw" dim="Dimensionless" quantityType="0" />
-                    <Container id="ynRDnvqvTUeXS_6jGHQ-qA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Tags>
-                        <Tag value="MoleculeProperties" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="ZknUSZcty0WxYs-xReFgxw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_kid" dim="Dimensionless" quantityType="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="wCRMVktFRESZSVW-L5fKcg" name="Urine" description="Urine compartment used to collect the fraction excreted to urine" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Urine" />
-                    <Tag value="Kidney" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="VkQ6NjWt-UqlKCC0jUkAsA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="qR_itsvghk6qcQs0Mx-jLA" dim="Volume" quantityType="0" />
-                    <Container id="yYdCpJv3GEmdBkvPPc1_fg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Tags>
-                        <Tag value="MoleculeProperties" />
-                      </Tags>
-                    </Container>
-                  </Children>
-                </Container>
-              </Children>
-            </Container>
-            <Container id="bij05GoSbU-hq-uKYRfbTA" name="Lumen" description="Lumen" icon="Lumen" mode="Logical" containerType="Organ">
-              <Tags>
-                <Tag value="Lumen" />
-              </Tags>
-              <Children>
-                <Parameter id="fLCkPPGLqEGZ6ioQj8QsIw" name="OralApplicationsEnabled" description="Enables/disables all transports between mucosa and lumen" persistable="0" isFixedValue="0" formula="Q79YGaXrhkKZa4lXwBdxVg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="M929zlOD4kmPYJ_7mSxXew" name="Paracellular absorption sink condition" description="Flag for conditions of the environment for paracellular absorption: 1= no sink condition, 0 = sink condition" persistable="0" isFixedValue="0" formula="99CFdykbjkuICStIuFHVqg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="eUCdefRS60C1YoZKj5EHhg" name="Transcellular absorption sink condition" description="Flag for conditions of the environment for transcellular absorption: 1=no sink condition, 0=sink condition" persistable="0" isFixedValue="0" formula="ADY_mUJ0GESV1mO9segx3w" dim="Dimensionless" quantityType="0" />
-                <Container id="hnGAUcV_iUqKJigxybLqhQ" name="Stomach" description="Stomach" icon="Stomach" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Stomach" />
-                    <Tag value="Lumen" />
-                    <Tag value="LumenSegment" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="6_2DGrsnYEKU4v1XzULeKQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                    <Parameter id="ogEIj3Wxs0S6eq_fi9V2fA" name="Volume (gut wall)" description="Volume of the gut wall" persistable="0" isFixedValue="0" formula="MucosaVolume.PARAM_VolumeGutWall" dim="Volume" quantityType="0" />
-                    <Parameter id="gO-r-h48n0mUUlYcq1XROQ" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_FillLevel" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="4rzko1bVikqqWZrPMaOi-g" name="FillLevelFlag" description="Fill Level Flag" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_FillLevelFlagFlag" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="RDykxrBHaEyuJYzYCMx-Vw" name="Geometric surface area" description="Geometric surface area of GI segment" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_Area" dim="Surface" quantityType="0" />
-                    <Parameter id="ydr5yVXGyEuvqUMKhoU6Gw" name="GET of non-disintegrated moiety" description="Gastric emptying time of the non-disintegrated moiety" persistable="0" isFixedValue="0" formula="aY5JeQi8k0KzUvnVKhFlew" dim="Time" quantityType="0" />
-                    <Parameter id="8NaRHfqw70-htfqQSb577A" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_InverseGastricEmptyingTime" dim="InversedTime" quantityType="0" />
-                    <Parameter id="mSz-LDE5pkOHI-b1sK3yEw" name="Liquid" description="Liquid" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_Liquid_StartValue" dim="Volume" quantityType="0" rHSFormula="Lumen_PKSim.LiquidRHS_sto" />
-                    <Parameter id="fWLQ1Xa100y1ReH58FWRaw" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_LiquidTransferRate_sto" dim="Rate" quantityType="0" />
-                    <Parameter id="VG11-EVUMkSFwxiQvorTLg" name="pH" description="pH" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_pH_from_pH_fasted" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="EcVCCUAco0GL53So43KVwg" name="Secretion of liquid" description="Rate of liquid inflow" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_Inflow_Stomach" dim="Flow (volume)" quantityType="0" />
-                    <Parameter id="L5aLDmI3E06tNFVWSLlMQg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_LumenSegment" dim="Volume" quantityType="0" />
-                    <Parameter id="xjfy5HoD5kOPFlCEIgzjpQ" name="Absorption of liquid" description="rate of liquid outflow" persistable="0" isFixedValue="0" formula="pE_F0tQ62U6bSb0yI7SrBQ" dim="InversedTime" quantityType="0" />
-                    <Parameter id="R-fckuN5BUSec7T6CfLlRQ" name="pH in fasted state" description="pH in fasted state" persistable="0" isFixedValue="0" formula="qovug8coIE2B4Hrz5DT2Kg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="M1V2D6SE2EST2dgxKrBTng" name="Inverse rate of inflow of liquid into stomach" description="Inverse rate of inflow of liquid into stomach" persistable="0" isFixedValue="0" formula="aLWW6oHTB0ChsRvjiHTtag" dim="Time" quantityType="0" />
-                    <Parameter id="KkFOnuQaKUySaSr5fsQ02g" name="Gastric emptying time" description="Gastric emptying time" persistable="0" isFixedValue="0" formula="MlI265LwZESCg4524965Og" dim="Time" quantityType="0" />
-                    <Parameter id="SYprDksJJ0qjr2tMeZOyxg" name="pH in fed state" description="pH in fed state" persistable="0" isFixedValue="0" formula="gjCKmampUEe8VzOFLDQOmg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="QqjYoBpHeEWZngJfaGCHZg" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" persistable="0" isFixedValue="0" formula="oIdTxJa4wEyKgPuWsEyOJw" dim="Fraction" quantityType="0" />
-                    <Parameter id="HN-YBf_NUUqvvRvZxtMBnw" name="Thickness of gut wall" description="Thickness of Gut Wall" persistable="0" isFixedValue="0" formula="zthLBR7_aUCgGp-IOc5Dkg" dim="Length" quantityType="0" />
-                    <DistributedParameter id="aVXU9a53vE-dm6RfIMdU2A" name="Distal radius" description="Distal radius of intestinal segment" persistable="1" isFixedValue="0" formula="IeYiFooLWEuvqC9skfIP5w" dim="Length" quantityType="0" mode="Logical">
-                      <Children>
-                        <Parameter id="ll8Uaq2xYk-K_5mbDw3orw" name="Percentile" persistable="0" isFixedValue="0" formula="he__VFBWXUCgga9iEw8vIw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="LtqBpyuM20CWcL-D6wU7WQ" name="Mean" persistable="0" isFixedValue="0" formula="uo7bF38XH0qTn_YLDZ4fdg" dim="Length" quantityType="0" />
-                      </Children>
-                    </DistributedParameter>
-                    <DistributedParameter id="po2_FsJQiUWqnNndUbTMTQ" name="Proximal radius" description="Proximal radius of intestinal segment" persistable="1" isFixedValue="0" formula="Ph5HiWjS70qpSxOwflRe0A" dim="Length" quantityType="0" mode="Logical">
-                      <Children>
-                        <Parameter id="UqBCfGjUp0WOT9ZuYgMC6Q" name="Percentile" persistable="0" isFixedValue="0" formula="dWmG6uCCkkal5vcYsHyN8w" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="WRxAqZmCMEGrYX4TPRz93Q" name="Mean" persistable="0" isFixedValue="0" formula="mpGNFhrwlky1Nv8CYI-VWg" dim="Length" quantityType="0" />
-                      </Children>
-                    </DistributedParameter>
-                    <DistributedParameter id="GkCj_wk2pkG3btuLTuPVAw" name="Length" description="Length" persistable="1" isFixedValue="0" formula="i0X7IM8uT0qR5SjFOp3lqw" dim="Length" quantityType="0" mode="Logical">
-                      <Children>
-                        <Parameter id="mQ3NKbyYWU2Zq53RRBEoDw" name="Percentile" persistable="0" isFixedValue="0" formula="EUyR2Ay_l02K69ilhj6VKQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="pHVr4Fusg0CYQkGSIyf3hA" name="Mean" persistable="0" isFixedValue="0" formula="hdMtyD4bU0SGfMejJT4sLA" dim="Length" quantityType="0" />
-                      </Children>
-                    </DistributedParameter>
-                    <Container id="M_MyaB3iT0SS3mgEkvlfrw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Tags>
-                        <Tag value="MoleculeProperties" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="2Plh2-04Jk-W4OBWBJBhdw" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="IVINnLuBvECeun--_ZjVlA" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="aqUhYpAOFUeUjrBn4rufqw" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="V01xnpbZ7EmlYlyopblAEw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="-eQ7jLzUdUufs1LpthlH4A" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="sFiXgmBvCkmcX6GCxRF2fw" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="IoiYRCvdA0CddJiQmGlrvA" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="6lp4Re_BLki2JOe8Rn1RzQ" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="pv4e-bNqE06wSvpFVDDi7A" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="KhYWthz0BE6lOdolZwkxQg" name="Solubility" description="Solubility" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_IntestinalSolubility" dim="Concentration" quantityType="0" />
-                        <Parameter id="a7ikM9F2hkyTh5_8aWqFrA" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="Pl3Ykofw6UqO4ug9BmWB_w" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="Xjvigo4VVECkO4Nmyi0KiA" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="4sDoumvbTUeXW1JScnpYfg" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="lcNdyoUgCU2xsPt0YlUtOQ" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" dim="Dimensionless" quantityType="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="0GDB2v61NEaYOE7qtRF98A" name="Duodenum" description="Duodenum" icon="Duodenum" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Duodenum" />
-                    <Tag value="Lumen" />
-                    <Tag value="LumenSegment" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="zmPb6S-iSU-miAg3eJOGTw" name="Distal radius" description="Distal radius of intestinal segment" persistable="0" isFixedValue="0" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R2" dim="Length" quantityType="0" />
-                    <Parameter id="KnzOjQYxZUCXCeIGLugQqg" name="FillLevelFlag" description="Fill Level Flag" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_FillLevelFlagFlag" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="ncAkySl6P0ODP5l-XdcpVA" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_FillLevel" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="Mawu6QEwC0Kj7fs7TYrAqA" name="Geometric surface area" description="Geometric surface area of GI segment" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_Area" dim="Surface" quantityType="0" />
-                    <Parameter id="tMv3Xqff-UyAJHYrEMhkoA" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_InverseSITT_Factor_Duodenum" dim="InversedTime" quantityType="0" />
-                    <Parameter id="Vz0iZdf4UEuBZVbcE_pV6A" name="Length" description="Length" persistable="0" isFixedValue="0" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Length" dim="Length" quantityType="0" />
-                    <Parameter id="CGUoo0rEBUW_skN4T9RQJg" name="Liquid" description="Liquid" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_Liquid_StartValue" dim="Volume" quantityType="0" rHSFormula="Lumen_PKSim.LiquidRHS_duo" />
-                    <Parameter id="4RDDfS2O7UCxnGbI9ZqXug" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_LiquidTransferRate_duo" dim="Rate" quantityType="0" />
-                    <Parameter id="CMn8x9kLbESNWFgVuwZlAA" name="Proximal radius" description="Proximal radius of intestinal segment" persistable="0" isFixedValue="0" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R1" dim="Length" quantityType="0" />
-                    <Parameter id="y-1VF8v0mEOgdBFg7XfpqQ" name="Thickness of gut wall" description="Thickness of Gut Wall" persistable="0" isFixedValue="0" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Thickness" dim="Length" quantityType="0" />
-                    <Parameter id="eBt73YKeSkeISONvNYCm4w" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_LumenSegment" dim="Volume" quantityType="0" />
-                    <Parameter id="U4eMXuT-oUK6MTd-f196QA" name="Volume (gut wall)" description="Volume of the gut wall" persistable="0" isFixedValue="0" formula="MucosaVolume.PARAM_VolumeGutWall" dim="Volume" quantityType="0" />
-                    <Parameter id="lrv05Zpiy06UI0rkRTQpIQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                    <Parameter id="gAReVu_rgkmN7OaEsryT2g" name="Secretion of liquid" description="Rate of liquid inflow" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_Inflow_Duodenum" dim="Flow (volume)" quantityType="0" />
-                    <Parameter id="Dl7ubKDCCU6JovjbxT40EQ" name="Absorption of liquid" description="rate of liquid outflow" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_Outflow_Duodenum" dim="InversedTime" quantityType="0" />
-                    <Parameter id="oyBWioPfuUeTGxHCnqTgPg" name="pH" description="pH" persistable="0" isFixedValue="0" formula="H_1jf3KANU-UgCXwF5DHrg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="pK0XzhO-bEu4BOX3d_m1Dg" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" formula="HODDkb9Saky01owcvUw9kw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="pwI_ccGJM0KEsh3rmsoMGQ" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" persistable="0" isFixedValue="0" formula="uO4WGhbykEqsAISJVh8jRQ" dim="Fraction" quantityType="0" />
-                    <Parameter id="kA9Z4tdQpk-da4NxfVDcbw" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="MBk-TZG-PUG-ez-4pPPpSg" dim="Length" quantityType="0" />
-                    <Parameter id="6j6fh6WAgECw-TApgPsnCg" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" formula="NiQD2TBO8kunD3OcIY0BHA" dim="InversedLength" quantityType="0" />
-                    <Parameter id="Z8UmbBKxhUuz-vKf6FsmvA" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" formula="KCS4Rn8UGE-5VkZYGnR1Og" dim="Length" quantityType="0" />
-                    <Parameter id="VcPDIZZ-hkyq1ImFkvVPtg" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="XuSGBePpBk-ITjI0VeNfyQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="Vfzm95MNn0-R2VlCIx8nUw" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="5uYDe8LH_EelG45MQIkSqA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="lGL0ihJdxUy5XdPtXdICLw" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="EmyF8EqfJk6_ka6PBqIgbQ" dim="Length" quantityType="0" />
-                    <Parameter id="jT2WNWfZuk6241vm0I7s8g" name="Microvilli factor" description="Microvilli factor" persistable="0" isFixedValue="0" formula="Hk2aZeOI-ECYXqt7V5_bEw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="tAyBN4K9Gk2JM-7k0Ob1LQ" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="LnybbwnpnkyGWuT9u5rWuw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="sYVT9YsejkiWrHks8CJQRQ" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="IwoYHZkK4kmGCX-h3DUdxQ" dim="Length" quantityType="0" />
-                    <Parameter id="JJC-1wagm0OoZOCNfeW4FQ" name="Intestinal transit rate" description="Transit rate along intestinal segments" persistable="0" isFixedValue="0" formula="1d-sWkhBgk2yKbRAtwMMcQ" dim="InversedTime" quantityType="0" />
-                    <Parameter id="pX4c8QpUM0-K5xgOk_mU9g" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" formula="EVQpuTiatU63vS-xGL_RLw" dim="Length" quantityType="0" />
-                    <Container id="b9_8MxckJEy-ldxn5n3MJw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Tags>
-                        <Tag value="MoleculeProperties" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="LukTqrf7X0K_fAe8thHIHg" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="AiWzcCqIh0qBNygEGaRT2A" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="nMKy90GcKEGXxOXh39mXfQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="cRaAsjbuY0e0GEk7xNylrg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="XwLBn0JHC0qcl1I_BMxj0w" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" persistable="0" isFixedValue="0" formula="IUhe8Bk9fESenFgdfSH6yw" dim="Amount" quantityType="0" rHSFormula="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_duo" />
-                        <Parameter id="bywauQeMfUCBAj-w7ywmow" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="XC-eRrpM4ker-rYTZyffzA" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="DJ8Gsmw4sEe5SSPkNjuFyQ" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="s8172ibvwUGD4Fs1XztXZw" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="Xyj2VFornU2VBqJN_Bgfqw" name="Solubility" description="Solubility" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_IntestinalSolubility" dim="Concentration" quantityType="0" />
-                        <Parameter id="qoBBa4ubf0qiI7_vdOPYwQ" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="joiIQy_Be0GpIFLm4dmMRA" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="fYo6Kbu9C02SU-IW5eIWHA" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="V7CbOutZBEe_0H6xrq4I4Q" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="FnEWT96sO0C1gMQQDhtXfA" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="gVYiSfcpoEOZkgRmmLWX4A" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" dim="Dimensionless" quantityType="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="pv8ky3IO4EKyi5gJ8H1ypw" name="UpperJejunum" description="Upper Jejunum" icon="UpperJejunum" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="UpperJejunum" />
-                    <Tag value="Lumen" />
-                    <Tag value="LumenSegment" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="cEy3ELfRmU2dsiYDOXk_Rw" name="Absorption of liquid" description="rate of liquid outflow" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_Outflow_UpperJejunum" dim="InversedTime" quantityType="0" />
-                    <Parameter id="zyMnUaWQ4EKxBWRueTzrXQ" name="Distal radius" description="Distal radius of intestinal segment" persistable="0" isFixedValue="0" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R2" dim="Length" quantityType="0" />
-                    <Parameter id="Kgu0KuV1O0Ku695j7pL_aQ" name="FillLevelFlag" description="Fill Level Flag" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_FillLevelFlagFlag" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="gfW1OxANnkO6Km1oOJO4lw" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_FillLevel" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="TIaKYVOAbE6018OGPKfqsw" name="Geometric surface area" description="Geometric surface area of GI segment" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_Area" dim="Surface" quantityType="0" />
-                    <Parameter id="cKvic4z2YUaiP6e-katGmA" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_InverseSITT_Factor_UpperJejunum" dim="InversedTime" quantityType="0" />
-                    <Parameter id="ptI59THVbkWgGANfE3efiw" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_LiquidTransferRate_uje" dim="Rate" quantityType="0" />
-                    <Parameter id="5tH-7u-E-Eq754PV19On9w" name="Length" description="Length" persistable="0" isFixedValue="0" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Length" dim="Length" quantityType="0" />
-                    <Parameter id="BOOUwhXAA0udO5FoI-oxZw" name="Proximal radius" description="Proximal radius of intestinal segment" persistable="0" isFixedValue="0" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R1" dim="Length" quantityType="0" />
-                    <Parameter id="61U-YKjGzUmOyhYSumnJOQ" name="Secretion of liquid" description="Rate of liquid inflow" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_Inflow_UpperJejunum" dim="Flow (volume)" quantityType="0" />
-                    <Parameter id="mGJal4VA_ECGHbfLdgQ6xw" name="Thickness of gut wall" description="Thickness of Gut Wall" persistable="0" isFixedValue="0" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Thickness" dim="Length" quantityType="0" />
-                    <Parameter id="2Tg-uiCJiU2xkrHmd6wh7g" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_LumenSegment" dim="Volume" quantityType="0" />
-                    <Parameter id="_B8FIyzdiUu0AqbSXzUx3Q" name="Volume (gut wall)" description="Volume of the gut wall" persistable="0" isFixedValue="0" formula="MucosaVolume.PARAM_VolumeGutWall" dim="Volume" quantityType="0" />
-                    <Parameter id="YUg6TAcA8k20wmAN5oKXog" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                    <Parameter id="HL8f_8BaVkWFJUY6tF_PMA" name="Liquid" description="Liquid" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_Liquid_StartValue" dim="Volume" quantityType="0" rHSFormula="Lumen_PKSim.LiquidRHS_uje" />
-                    <Parameter id="6trf88RqzkG9bMsrQWi9jw" name="pH" description="pH" persistable="0" isFixedValue="0" formula="PxOH7YNmxEinvQklOVussg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="2A1F9k8gK0eY0LGrG_E4Dw" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="Q4kPBqPWFkCx7VsOtm5Abw" dim="Length" quantityType="0" />
-                    <Parameter id="2paOCoK2xkqIaSRNBTZ0aA" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" persistable="0" isFixedValue="0" formula="dWyVMw4gLEOfci1iqjlXGw" dim="Fraction" quantityType="0" />
-                    <Parameter id="F8aMuLY5Tky-7RbL73grGA" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" formula="fsLjjW04iEGzatRwCvALbw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="lWHbz9U6JEatExBvp2fOQA" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="0A8u921Drkq4z4I9_U2OHA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="flk15pFCsE2FqUT33gRwfQ" name="Intestinal transit rate" description="Transit rate along intestinal segments" persistable="0" isFixedValue="0" formula="Dft85e4BmEKrhG4Lx-G0Pg" dim="InversedTime" quantityType="0" />
-                    <Parameter id="xrKtrhNOfEW1L7eQfeHsOA" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" formula="S-eC8Q8UZEeMRN_jQYk0GQ" dim="Length" quantityType="0" />
-                    <Parameter id="7NSYffI8UE-bTvJNpV-CYQ" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" formula="OTDUMCFP80O2ACQbfmsfMA" dim="InversedLength" quantityType="0" />
-                    <Parameter id="F_tNgfBps06OEZnJeSq7_w" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" formula="4XDUC_apiUaYOBbtp7LhwQ" dim="Length" quantityType="0" />
-                    <Parameter id="BJSI6XA5WEuFQPAVoR7bdw" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="EuQ0sSp-ikiK2BhTRaOtGA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="DwekcCP_8U-1hGtLOOAUFQ" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="eT9WZ_eRu0mfwmAfTJ-Fzg" dim="Length" quantityType="0" />
-                    <Parameter id="M_86okxF9Uq3fqSuAkQ6nw" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="xpDfDM6iAUChmTvo_-cggw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="Ie36bwFOdkG68YZIsepb6Q" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="E05Yb87U5k2RfOEIZ46GOw" dim="Length" quantityType="0" />
-                    <Parameter id="DSFarn2ubUCMmEwOCqAU6Q" name="Microvilli factor" description="Microvilli factor" persistable="0" isFixedValue="0" formula="jCVxip_HJUyGMyfHUj6E6Q" dim="Dimensionless" quantityType="0" />
-                    <Container id="O08l3XJPkUilsft7v03zaw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Tags>
-                        <Tag value="MoleculeProperties" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="D5NKWR4-J0WxnqHnjjoeFA" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="PH42uyescE2ZOHBUedFOoQ" name="Solubility" description="Solubility" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_IntestinalSolubility" dim="Concentration" quantityType="0" />
-                        <Parameter id="bJdlcKftsEWkJTrYO0dVBA" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="_fd59MIt-U6fEySyt7eJJw" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="SwI5pGVMtkyc_wUav6xBmQ" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="CO1vuLscrEOi_eO09Tp2Lg" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="VxHGqNQIkUCvWdRuuwHY-g" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="JgHxRGxi4kSdVEFr91gyIQ" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="b9gH-AJro024tDdOlmcVVQ" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="8BNIbw2Z2EyMubr7RjPCqw" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="3VBtjtBoTEO4eUaxTlsAzg" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="pHnPgPL74Eq9uen7BRQIpQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="sAQn92ou40K7pkYSbkFt-w" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="8RPM99SqfE65iAfv7hjP-A" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" persistable="0" isFixedValue="0" formula="vdcTblntY0aUz36jo1p5Nw" dim="Amount" quantityType="0" rHSFormula="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_uje" />
-                        <Parameter id="p_UGbxMsCk-FQYsazLF_gg" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="TM9WbiGf_0GiAbFrK-abNQ" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" dim="Dimensionless" quantityType="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="zK9Pbyu03UyPlyTlgcagCw" name="LowerJejunum" description="Lower Jejunum" icon="LowerJejunum" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="LowerJejunum" />
-                    <Tag value="Lumen" />
-                    <Tag value="LumenSegment" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="BiuJJB4cOkersmPiskQWsw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_LumenSegment" dim="Volume" quantityType="0" />
-                    <Parameter id="mwq8s3tovUyiLSk6P-3CKA" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_FillLevel" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="zQkiQTBYik-_ha0YcOMoZA" name="Absorption of liquid" description="rate of liquid outflow" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_Outflow_LowerJejunum" dim="InversedTime" quantityType="0" />
-                    <Parameter id="b04w60CcsUGgJnDTPNEF9g" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                    <Parameter id="dsyQKP1yzUONaUa4co1wJg" name="FillLevelFlag" description="Fill Level Flag" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_FillLevelFlagFlag" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="Y7mm3DrKukWGOvVAUY_M3w" name="Volume (gut wall)" description="Volume of the gut wall" persistable="0" isFixedValue="0" formula="MucosaVolume.PARAM_VolumeGutWall" dim="Volume" quantityType="0" />
-                    <Parameter id="Lxcz3M9sGEOgZvcfsxppfQ" name="Geometric surface area" description="Geometric surface area of GI segment" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_Area" dim="Surface" quantityType="0" />
-                    <Parameter id="IABk6MfcaU-0auGA920wcw" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_InverseSITT_Factor_LowerJejunum" dim="InversedTime" quantityType="0" />
-                    <Parameter id="w7_30yRE-EyECYcXEHdWEQ" name="Length" description="Length" persistable="0" isFixedValue="0" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Length" dim="Length" quantityType="0" />
-                    <Parameter id="QnsVJfw0HkmjXXm_-5ygfQ" name="Liquid" description="Liquid" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_Liquid_StartValue" dim="Volume" quantityType="0" rHSFormula="Lumen_PKSim.LiquidRHS_lje" />
-                    <Parameter id="CxHc_0ltcUqFyM_-GxdBZw" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_LiquidTransferRate_lje" dim="Rate" quantityType="0" />
-                    <Parameter id="My54eDEVmEGsLaY1XB7juw" name="Proximal radius" description="Proximal radius of intestinal segment" persistable="0" isFixedValue="0" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R1" dim="Length" quantityType="0" />
-                    <Parameter id="g_RDO9jVyUSYfQ6s9e2gcA" name="Secretion of liquid" description="Rate of liquid inflow" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_Inflow_LowerJejunum" dim="Flow (volume)" quantityType="0" />
-                    <Parameter id="Ude3UHRPt0ewtaDV_eineQ" name="Thickness of gut wall" description="Thickness of Gut Wall" persistable="0" isFixedValue="0" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Thickness" dim="Length" quantityType="0" />
-                    <Parameter id="lfJZzAfUIUe4t-F18NwQkg" name="Distal radius" description="Distal radius of intestinal segment" persistable="0" isFixedValue="0" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R2" dim="Length" quantityType="0" />
-                    <Parameter id="8oJ46PTgHUqRDNdOctkjXQ" name="pH" description="pH" persistable="0" isFixedValue="0" formula="INmvi7ad8UGbKPoTxTChoQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="0KEY-IhtvkKx7S59Z6DiYA" name="Microvilli factor" description="Microvilli factor" persistable="0" isFixedValue="0" formula="k8J3_Bj3-EquYvu-jcOAQg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="TFMblI4n60eop8NFAiOutA" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="lDAUqM7uCkSshGSG4Pb3rA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="xUglvf_IO0KUOeCiQswYsQ" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="DMMMZz1agU2L6axN_enYvQ" dim="Length" quantityType="0" />
-                    <Parameter id="lTRr_9eaG0-MtjW7HknAng" name="Intestinal transit rate" description="Transit rate along intestinal segments" persistable="0" isFixedValue="0" formula="wcI6-rdyc0KJ0oKrLn_sSw" dim="InversedTime" quantityType="0" />
-                    <Parameter id="Irk-hmxAuU2S_aLVCkwLLQ" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" persistable="0" isFixedValue="0" formula="q9v5w9A9EUSwU_6csIlfNg" dim="Fraction" quantityType="0" />
-                    <Parameter id="EkvWBAswMkaU4u2VZkTXbQ" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="SDcOc-BMxE2NN5t_UVKWmQ" dim="Length" quantityType="0" />
-                    <Parameter id="OA0Jp-Ty1EKXHK-sIgUZFA" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" formula="a1n2jVN4KEetOgH8atxhIg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="O_Al5iDMlEWMrA307oyMUQ" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="_YA8iiqgnEuHRPeSzOuf1w" dim="Length" quantityType="0" />
-                    <Parameter id="52Gd1iYs0E6wblZOqA8Hyg" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="1YAJM-neT0SVGYU6FahepQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="v5bqA2HSzkCjWGURvqH4tQ" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" formula="jt66tQphk0-UwbiYoliKVQ" dim="InversedLength" quantityType="0" />
-                    <Parameter id="JRyol2dTzUOeBzR7gCmWhw" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" formula="zmVWH4vzOUCYnKljrGpz1g" dim="Length" quantityType="0" />
-                    <Parameter id="5_iI-KgiYUuIkr9KaUaq-w" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" formula="dATPxtkKUUqLL0s_8YmMdQ" dim="Length" quantityType="0" />
-                    <Parameter id="Hv2TvJE3Vkq0HUONUNG0Dw" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="5xAUXKWzhUONvoUnHgQdAA" dim="Dimensionless" quantityType="0" />
-                    <Container id="nzHnoWeXu0CN4_tLaVJJUw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Tags>
-                        <Tag value="MoleculeProperties" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="5O8SdAZmWkyn34_jo0wgWw" name="Solubility" description="Solubility" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_IntestinalSolubility" dim="Concentration" quantityType="0" />
-                        <Parameter id="-TjbvuRjpU6Ef_YhMVU1ZQ" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="A802tBPs-Ee0hjmFlQ9JRw" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="0V6y2WifwE-uE0YL2gbbgQ" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="Q-qn45_Srk-CG1YnGfHleQ" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="Pzfx1n3nBE6xBV05hmZlGQ" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="tx57XDUwCUGFC78RCRquMg" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="aY6DFe-hME6IjKx4xzps2A" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="xBvIu52E8EKVOxiVKxZb1g" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="jkL35Rl3uUO6vmVfnL3DfQ" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="N38K_MTKykKQc5EAB4wgUg" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="3FseT7Q-EkSn6kfF_yWELQ" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="zikPkdy-a06PFNBpmFtBVw" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" persistable="0" isFixedValue="0" formula="RRfKTKih8EWmTHxGkmDuDw" dim="Amount" quantityType="0" rHSFormula="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_lje" />
-                        <Parameter id="U07aqItaQUqupjfxgwFp_g" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="sRsnZ3zueU2tZRyEV1B3bg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="ZswS3wHS3U-tI4vzLySypA" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" dim="Dimensionless" quantityType="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="Lyr8qWpSH02MuqWATY6opQ" name="UpperIleum" description="Upper Ileum" icon="UpperIleum" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="UpperIleum" />
-                    <Tag value="Lumen" />
-                    <Tag value="LumenSegment" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="rkna1lbu7EmbJExXWszDdg" name="Absorption of liquid" description="rate of liquid outflow" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_Outflow_UpperIleum" dim="InversedTime" quantityType="0" />
-                    <Parameter id="sqLFeZBNPkSDXo674-HZ9w" name="Distal radius" description="Distal radius of intestinal segment" persistable="0" isFixedValue="0" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R2" dim="Length" quantityType="0" />
-                    <Parameter id="AIBQJ5q5HkKvDMGF7AUT3g" name="FillLevelFlag" description="Fill Level Flag" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_FillLevelFlagFlag" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="r3sEAtg7wEqGsXodcXLYKw" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_FillLevel" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="Bn73owPACUiPh68ogHwhOA" name="Geometric surface area" description="Geometric surface area of GI segment" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_Area" dim="Surface" quantityType="0" />
-                    <Parameter id="DCbrljC3okicowTPcNKgFg" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_InverseSITT_Factor_UpperIleum" dim="InversedTime" quantityType="0" />
-                    <Parameter id="pJ-ghVQ3hk6Q17dcQUYmig" name="Length" description="Length" persistable="0" isFixedValue="0" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Length" dim="Length" quantityType="0" />
-                    <Parameter id="A6wIKgs_xE25IhN1_ijtsw" name="Liquid" description="Liquid" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_Liquid_StartValue" dim="Volume" quantityType="0" rHSFormula="Lumen_PKSim.LiquidRHS_uil" />
-                    <Parameter id="04dnhDLN4E6nfEfsVA0iaw" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_LiquidTransferRate_uil" dim="Rate" quantityType="0" />
-                    <Parameter id="hc16Vsz7SU67YuNZyPZsgA" name="Proximal radius" description="Proximal radius of intestinal segment" persistable="0" isFixedValue="0" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R1" dim="Length" quantityType="0" />
-                    <Parameter id="PdG2dHXw3k6T9cypKGN-OQ" name="Thickness of gut wall" description="Thickness of Gut Wall" persistable="0" isFixedValue="0" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Thickness" dim="Length" quantityType="0" />
-                    <Parameter id="mkUf6mqVl0GYD8wtFnmxlw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_LumenSegment" dim="Volume" quantityType="0" />
-                    <Parameter id="APj9oahiP0izuYKS9f1DKw" name="Volume (gut wall)" description="Volume of the gut wall" persistable="0" isFixedValue="0" formula="MucosaVolume.PARAM_VolumeGutWall" dim="Volume" quantityType="0" />
-                    <Parameter id="hncK7e7rxE-NurqpaWEiEQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                    <Parameter id="ZatSKP3fMUKbY-jh8HxDSQ" name="Secretion of liquid" description="Rate of liquid inflow" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_Inflow_UpperIleum" dim="Flow (volume)" quantityType="0" />
-                    <Parameter id="otOyXTQtUUCvYLvUjFXQiQ" name="pH" description="pH" persistable="0" isFixedValue="0" formula="l_s1bGwqD02w8H_ytZnKZg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="y38pE-yZ-EGFQJRgYqW3Ew" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" formula="GJAjcK75VEGgC2W2i4vtuA" dim="InversedLength" quantityType="0" />
-                    <Parameter id="px-WkvzKo0GkWyAGzap9IA" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="2v00qoVlnECw5KFRuTltYw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="0UJSMoKb_0uf_kKU2TIAxg" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" formula="MWjvGS_al0Gu-R5vYk6gEQ" dim="Length" quantityType="0" />
-                    <Parameter id="MDpHP7YZt0SoqZuKWY9iWw" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" persistable="0" isFixedValue="0" formula="Rzmm4S8XiEqsG8FvyTAQng" dim="Fraction" quantityType="0" />
-                    <Parameter id="IAYAaVUAKEeqlE0RyiJF2Q" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="dt2immExXUqAF_IZ1gqVYQ" dim="Length" quantityType="0" />
-                    <Parameter id="_Z5AdLLCcUGwIkrfonxvyA" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="HCoUXSYro0-QjfjUCf_VHw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="ynhV-0I7MUydtCwZSjgX4g" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="Xy_smBZJqkW18VqP7JFiPA" dim="Length" quantityType="0" />
-                    <Parameter id="lszy2j4JF0mkNyRj1FjaXw" name="Microvilli factor" description="Microvilli factor" persistable="0" isFixedValue="0" formula="VKSQ2Cf4UUWNLsuaBOWEYg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="knDuqk3fT0aLWU7hoE-F7Q" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="UfuPEFeIf0yl3IKvJ7a72A" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="WL-zBMhpbUWDd2LOrnRYfQ" name="Intestinal transit rate" description="Transit rate along intestinal segments" persistable="0" isFixedValue="0" formula="JgaG0scGBU2QzdHH0h48Yw" dim="InversedTime" quantityType="0" />
-                    <Parameter id="CmPQSSlEPUK_t8RlLXowTQ" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" formula="2wljIh3dZ0qGzdUZcukvlg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="7MZBbBnlkk-C2uCS9Dmurg" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" formula="dIZ9Wht6DEuYDp5sGUA0ow" dim="Length" quantityType="0" />
-                    <Parameter id="SidQJ9m0IUCRSMgLnclV4w" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="96ny9wtFMU6_2Nn4o_5FRw" dim="Length" quantityType="0" />
-                    <Container id="9Mh_Ay-lB0u9BAM6Tqadrw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Tags>
-                        <Tag value="MoleculeProperties" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="JX9H1lABaUukNQfVTNM3TQ" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="iA0QGDHmrUG9FzkCx0Aehw" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="QKM4-VK250u8GXRn05a0Og" name="Solubility" description="Solubility" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_IntestinalSolubility" dim="Concentration" quantityType="0" />
-                        <Parameter id="YKWXD_kdK0OZDUqCrMJJIA" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="tOsfxlfHFU224yS5ZzJL1w" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="1zS-boZfTkeL9BW9TA6Y2g" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" persistable="0" isFixedValue="0" formula="XgqzlBBhAEqioI0WZh6NJQ" dim="Amount" quantityType="0" rHSFormula="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_uil" />
-                        <Parameter id="9JqJ2eNdME2RyqFpPHbCEQ" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="8jmYb_NPZUWmL6ipOt6jFQ" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="vjQ3sGsDkU64GirDqXW08w" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="bJ_bY19J0Uuawo-Jc-ytpA" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="7mXR4OXuZkWAmzIX6Gvt4A" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="GbiT9pGOLEigMmH9MAICcA" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="GAcDr8Q-MEywnYHTvKI05g" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="YeWUEABo9EmMZxJxBwO_4A" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="f0l1k5-_CEmeaV1fmG5FuA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="_yy2KxXhWkGKUppXb826_A" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" dim="Dimensionless" quantityType="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="fEBnSbA_6USbWW4hwxLwgA" name="LowerIleum" description="Lower Ileum" icon="LowerIleum" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="LowerIleum" />
-                    <Tag value="Lumen" />
-                    <Tag value="LumenSegment" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="s62dXtrOYEeXbRJ11pHt4g" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_LiquidTransferRate_lil" dim="Rate" quantityType="0" />
-                    <Parameter id="QPtJTy-KOk6B-sOGrju4XA" name="Proximal radius" description="Proximal radius of intestinal segment" persistable="0" isFixedValue="0" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R1" dim="Length" quantityType="0" />
-                    <Parameter id="nuYnvUVgJkKUNd4zRMaoxw" name="Secretion of liquid" description="Rate of liquid inflow" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_Inflow_LowerIleum" dim="Flow (volume)" quantityType="0" />
-                    <Parameter id="WnVwwch3LUKiWekArc5DbA" name="Thickness of gut wall" description="Thickness of Gut Wall" persistable="0" isFixedValue="0" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Thickness" dim="Length" quantityType="0" />
-                    <Parameter id="ykIDVlXAuU6EVWWi7XOT-w" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_LumenSegment" dim="Volume" quantityType="0" />
-                    <Parameter id="FvcSO4yjBEmmt2BEQCl5ZQ" name="Volume (gut wall)" description="Volume of the gut wall" persistable="0" isFixedValue="0" formula="MucosaVolume.PARAM_VolumeGutWall" dim="Volume" quantityType="0" />
-                    <Parameter id="jpE5Avb-MUquN4VtKjCi5w" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                    <Parameter id="IpIIkaZ2fE6cXM2R6jfq2Q" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_InverseSITT_Factor_LowerIleum" dim="InversedTime" quantityType="0" />
-                    <Parameter id="nOAyhhUJi0iQcM_hZdNPsA" name="Liquid" description="Liquid" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_Liquid_StartValue" dim="Volume" quantityType="0" rHSFormula="Lumen_PKSim.LiquidRHS_lil" />
-                    <Parameter id="Ww6Hpuq6AUGBrpSxFBMOZQ" name="Absorption of liquid" description="rate of liquid outflow" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_Outflow_LowerIleum" dim="InversedTime" quantityType="0" />
-                    <Parameter id="M7w3RQMp-UiCRhkIFB9qXQ" name="Distal radius" description="Distal radius of intestinal segment" persistable="0" isFixedValue="0" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R2" dim="Length" quantityType="0" />
-                    <Parameter id="cWsfGTvrP0ihXMlc2Ky7-Q" name="FillLevelFlag" description="Fill Level Flag" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_FillLevelFlagFlag" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="fOkLc8Np_kyntVY5HYkHkA" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_FillLevel" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="eWTilCqS2EO8mX3gu7D7BQ" name="Geometric surface area" description="Geometric surface area of GI segment" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_Area" dim="Surface" quantityType="0" />
-                    <Parameter id="nxpzqEY35UaYZihagBOXEw" name="Length" description="Length" persistable="0" isFixedValue="0" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Length" dim="Length" quantityType="0" />
-                    <Parameter id="4SehK65td0myDzqqGhAqew" name="Microvilli factor" description="Microvilli factor" persistable="0" isFixedValue="0" formula="35LHJOlkak-Eqkvu0SnOVg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="rR-wai7fnEib_egUMHHHOA" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" formula="EtL3JEdApkG1NNrlpV-eFg" dim="Length" quantityType="0" />
-                    <Parameter id="w1TcGwsakk-ULXarBZwZww" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="w6M8TZQ7O0GeTtus2wVnhw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="VgzIKgQeEUG-3IMZlYPelA" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="VtafeDX-v023CaV5YVdy_Q" dim="Length" quantityType="0" />
-                    <Parameter id="U3ifzzezQUyyYjEAlNwS1g" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="2Ezd8SgHFEKLKFC-pY6D9A" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="59Peda9oKUWpafBsBKUg-Q" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" formula="s6SIlw3zcUyi7TUO8B-vDA" dim="InversedLength" quantityType="0" />
-                    <Parameter id="f0THK_1I1kihG2ll3AK4og" name="pH" description="pH" persistable="0" isFixedValue="0" formula="EnnK9g43Y0i34SE3Aculhw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="Q0ABh6mcaUS37EsxN_xxMg" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="JTuz_mNsbk-8Ka0mmI0-bg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="Gcd0NJNGv0micS3Ene3UHA" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="otkTyHaEdEisgqZmml_s2Q" dim="Length" quantityType="0" />
-                    <Parameter id="CsqHlVbXVU2vlPULqPhK1g" name="Intestinal transit rate" description="Transit rate along intestinal segments" persistable="0" isFixedValue="0" formula="6NKCAfkVwEatA5v8F-5okw" dim="InversedTime" quantityType="0" />
-                    <Parameter id="chUfKA37CkaSOYlP-wQfXw" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" persistable="0" isFixedValue="0" formula="4qVv6_Z5wU-wTID6okTLxg" dim="Fraction" quantityType="0" />
-                    <Parameter id="wKbs-kzGpUiGslPHjwwK6Q" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" formula="yqoi4PHGt02xddCYg1VLZA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="Iy_TFVo9IU-1IL3pdNWfvw" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="MT9poEKNk0OXK2jLpW_jBQ" dim="Length" quantityType="0" />
-                    <Parameter id="94ZQHo4h1EubghzCfyrXTg" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" formula="wXyns6GGCEeF_n_dxhKF4A" dim="Length" quantityType="0" />
-                    <Container id="DIrWP_3lIUWrIqiwVFuX5Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Tags>
-                        <Tag value="MoleculeProperties" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="NzHQbGM24Ea_UxIGsTmS8Q" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="QPRBkag20Uy41I1ofqXqmg" name="Solubility" description="Solubility" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_IntestinalSolubility" dim="Concentration" quantityType="0" />
-                        <Parameter id="sLltRz1dYk-78qlQUxRntw" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="rh2RAUljJUatLDQfkBbdwQ" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="yE89TiIHtUK2LDkct1APxg" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="rMYYBKP_MkaST8MAngetCQ" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="p9TbP6hJBEGVeMo_-Q5yMA" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="MgV_VT87CEmM4FnHXIYclg" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="s0JPd54KSEKf0cm3smTF-g" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="ndKJGRi520G5uN6b4deeOw" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="up4VWCsTskif7nDPCaGgXw" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="t6KwaaAjOka3CVCMyEQXRQ" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="IVuO4-JFt0yBGUjw4LixEw" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="1Xq7xtxvP0a96Ta7iKQz1Q" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="ApKKHhQ0fU2Qr-BPtSifjA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="GVAcjYdFsEidxNvzXbwqfA" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" persistable="0" isFixedValue="0" formula="2w5-XhVnekGwbZgBuDWwRA" dim="Amount" quantityType="0" rHSFormula="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_lil" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="Tb_XB9kBdEijMjvfTLCFmg" name="Caecum" description="Cecum" icon="Caecum" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Caecum" />
-                    <Tag value="Lumen" />
-                    <Tag value="LumenSegment" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="jjWvxBmjq0iY05T5bwFPOQ" name="Volume (gut wall)" description="Volume of the gut wall" persistable="0" isFixedValue="0" formula="MucosaVolume.PARAM_VolumeGutWall" dim="Volume" quantityType="0" />
-                    <Parameter id="uvIrWPrYCEychjZMmtX2Pg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_LumenSegment" dim="Volume" quantityType="0" />
-                    <Parameter id="gxVQ8MVOEEu-rLT0CJ8iNw" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_FillLevel" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="ka3ySm4O0E21f0r2IuidgQ" name="Absorption of liquid" description="rate of liquid outflow" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_Outflow_Caecum" dim="InversedTime" quantityType="0" />
-                    <Parameter id="mLIGTDv4R0qPENUhQFwF0A" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                    <Parameter id="dh_Ibq863EOZ8XtIi346DA" name="FillLevelFlag" description="Fill Level Flag" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_FillLevelFlagFlag" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="Q-DdhzdqgUW6zKHQYEDUmQ" name="Geometric surface area" description="Geometric surface area of GI segment" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_Area" dim="Surface" quantityType="0" />
-                    <Parameter id="6syno-2ZKECDcRKXXEzqCQ" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_InverseLITT_Factor_Caecum" dim="InversedTime" quantityType="0" />
-                    <Parameter id="8VgN4sAgvEyhUcHFM25xeA" name="Length" description="Length" persistable="0" isFixedValue="0" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Length" dim="Length" quantityType="0" />
-                    <Parameter id="vZuQiPx_gkua09i7o4HJ_g" name="Liquid" description="Liquid" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_Liquid_StartValue" dim="Volume" quantityType="0" rHSFormula="Lumen_PKSim.LiquidRHS_cae" />
-                    <Parameter id="V4wzmuzQqUCYVAcLW_eaSA" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_LiquidTransferRate_cae" dim="Rate" quantityType="0" />
-                    <Parameter id="XGgzh20ZKkeu4yNwJWmKTg" name="Proximal radius" description="Proximal radius of intestinal segment" persistable="0" isFixedValue="0" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R1" dim="Length" quantityType="0" />
-                    <Parameter id="QeyNXTgQhUKPQg5mm6HPUw" name="Secretion of liquid" description="Rate of liquid inflow" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_Inflow_Caecum" dim="Flow (volume)" quantityType="0" />
-                    <Parameter id="X0LIhTxA60KPjlqTy_aEjw" name="Thickness of gut wall" description="Thickness of Gut Wall" persistable="0" isFixedValue="0" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Thickness" dim="Length" quantityType="0" />
-                    <Parameter id="ZBoRbvmOJkShadkeStxLkw" name="Distal radius" description="Distal radius of intestinal segment" persistable="0" isFixedValue="0" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R2" dim="Length" quantityType="0" />
-                    <Parameter id="GNFu33qekUmvFZWQOFaF8w" name="pH" description="pH" persistable="0" isFixedValue="0" formula="wVuiKMlsykyAygtyt0qYMg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="pp-B7gU5806dAbSfQIujZQ" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" formula="Rbgc9yRVm02Dma1dRkrA1g" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="1Dsie57PS0uNjvULtMda2A" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="XG9m_mGmM0Sw2TxpCGteuw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="aiEkZa_poEe_BEWpMFUmgw" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" formula="D3a5Hxi1Dk-sBoRpafD0lw" dim="InversedLength" quantityType="0" />
-                    <Parameter id="a_nifL8q7keqRf5HGrVyyQ" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" formula="PHNKqf0RQ06lZZxSHYkbUA" dim="Length" quantityType="0" />
-                    <Parameter id="D3j7Ji2MJEqep5KjHg1xOQ" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" formula="RTEQJKiyTE23oXBwaZN3rA" dim="Length" quantityType="0" />
-                    <Parameter id="f0p2PhDUT0WcyKn5LTteFg" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="Pm-sSe5GlE2pMjsEodUwsQ" dim="Length" quantityType="0" />
-                    <Parameter id="kQZfwZSNQ0m3pA3M8jCJFQ" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="LOj6FUEpj0CtE_2fQuUIzQ" dim="Length" quantityType="0" />
-                    <Parameter id="GeHvjJcQtUyDk_pk_OfVSg" name="Microvilli factor" description="Microvilli factor" persistable="0" isFixedValue="0" formula="yWbn213N5kafqkyHsGLmKQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="vDzSvrLLfkSdrRD1lCzD_Q" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="UvcxTxZFm0GzLP7iVPdBzA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="rb2Qfs36j0-3g8ufZh88BA" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="OcVqEMqvXkeCH0gxYh9pmw" dim="Length" quantityType="0" />
-                    <Parameter id="-QNgQjB3DUCOjxBB6EXzjg" name="Intestinal transit rate" description="Transit rate along intestinal segments" persistable="0" isFixedValue="0" formula="jduEfJWyhU2D25FZVFN2wQ" dim="InversedTime" quantityType="0" />
-                    <Parameter id="7qG17ilgQESZmfiCu2V2Uw" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" persistable="0" isFixedValue="0" formula="QVo4SSPgY06fP2Btrtw_VA" dim="Fraction" quantityType="0" />
-                    <Parameter id="7v-_yv1J-0Sjf9HDQjheLw" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="osv70mG2MESfba5Zletx4g" dim="Dimensionless" quantityType="0" />
-                    <Container id="3PQka_NiH0O70IT1sqbyDQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Tags>
-                        <Tag value="MoleculeProperties" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="gSJ-7ruVHk257JsPO4aXgA" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="n0PPfSro0kGLWzuyBLpYgg" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="kcFZHmLnNUqX9Fhma-qQnA" name="Solubility" description="Solubility" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_IntestinalSolubility" dim="Concentration" quantityType="0" />
-                        <Parameter id="Of-jQC57HEa9ubRzqx-hZA" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="pKjA400Twkq2aqCwkqZdhA" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="8cxh9UJBQUOD4BvHA0H8aw" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="B_UU0-iJi0qX9OquFphIhA" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="XbQN_0ksqk6DKnrkF_j62w" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="wE0q9oMya0OndQnka4htSQ" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="_4vVav9XCE-IUHIFm_pgog" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="kaDTGVUpMU6VVoE9ZV3zew" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="Ue9i7Shh8kK75cvTToEekg" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="8jx9_SzWn0yErhFhbTC7sw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="ioIgWmXxSkSZOnI3eTSfbQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="Tblf3qz1kkanyo1P5S5oZw" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" persistable="0" isFixedValue="0" formula="Z6_5mVMo7E6ZpBQ_Ib0SCA" dim="Amount" quantityType="0" rHSFormula="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_cae" />
-                        <Parameter id="clx3k6hFu0SuyaBbJYtd3g" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" dim="Dimensionless" quantityType="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="px9VS6HKjEufLOLkVEmyiQ" name="ColonAscendens" description="Colon Ascendens" icon="ColonAscendens" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="ColonAscendens" />
-                    <Tag value="Lumen" />
-                    <Tag value="LumenSegment" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="HLVFyOm9s0mMjXOy9DQNWw" name="Thickness of gut wall" description="Thickness of Gut Wall" persistable="0" isFixedValue="0" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Thickness" dim="Length" quantityType="0" />
-                    <Parameter id="rhERlXpYIE-B7Ie7i9XMcg" name="Absorption of liquid" description="rate of liquid outflow" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_Outflow_ColonAscendens" dim="InversedTime" quantityType="0" />
-                    <Parameter id="L7aQzFaCbkeyJD78OMftWw" name="Distal radius" description="Distal radius of intestinal segment" persistable="0" isFixedValue="0" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R2" dim="Length" quantityType="0" />
-                    <Parameter id="ksiUbo6R_E6UUmmgeUO_aA" name="FillLevelFlag" description="Fill Level Flag" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_FillLevelFlagFlag" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="PeEYl2ZOW0-l4HaqDBLCDQ" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_FillLevel" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="y43tyWi-HkK0-fO6GFniUQ" name="Geometric surface area" description="Geometric surface area of GI segment" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_Area" dim="Surface" quantityType="0" />
-                    <Parameter id="bk6ZXDd_e0ut1S2f0a-_KQ" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_InverseLITT_Factor_ColonAscendens" dim="InversedTime" quantityType="0" />
-                    <Parameter id="D4myJaTkP0GMv7iuk7WEpw" name="Length" description="Length" persistable="0" isFixedValue="0" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Length" dim="Length" quantityType="0" />
-                    <Parameter id="tGi4C0vA8kCwvbAgTafMrg" name="Liquid" description="Liquid" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_Liquid_StartValue" dim="Volume" quantityType="0" rHSFormula="Lumen_PKSim.LiquidRHS_colasc" />
-                    <Parameter id="0rjd4c1nxk-voMZuEG-3Gw" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_LiquidTransferRate_colasc" dim="Rate" quantityType="0" />
-                    <Parameter id="a-sUu1CQfkyTFdYoaA9Nhw" name="Secretion of liquid" description="Rate of liquid inflow" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_Inflow_ColonAscendens" dim="Flow (volume)" quantityType="0" />
-                    <Parameter id="CEKW0tdrGkeE3qO9rOabkQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_LumenSegment" dim="Volume" quantityType="0" />
-                    <Parameter id="PQJIaAKfREuI_Qr895_daQ" name="Volume (gut wall)" description="Volume of the gut wall" persistable="0" isFixedValue="0" formula="MucosaVolume.PARAM_VolumeGutWall" dim="Volume" quantityType="0" />
-                    <Parameter id="uBrd9yCi90utCgQhHuRagw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                    <Parameter id="B2G5qtChHEq0gLRU2e9Idg" name="Proximal radius" description="Proximal radius of intestinal segment" persistable="0" isFixedValue="0" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R1" dim="Length" quantityType="0" />
-                    <Parameter id="3kCGVdZNF0uFTVAETv6b7w" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="hcCSNzpW70-X6byOwnu-2g" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="r8Tz4tuq0EK1QvcKJhDs_g" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" formula="BwTSVcrWl0GEqFq_FEsRXQ" dim="InversedLength" quantityType="0" />
-                    <Parameter id="fECLIGToskuf4SVEyjnKGg" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" formula="Y1cHOGk3wUawkI1kOql4Eg" dim="Length" quantityType="0" />
-                    <Parameter id="YtHnhbzB9EWL3b3iERhWWA" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="N9kjj1qxFE6w_5RDRIqaJA" dim="Length" quantityType="0" />
-                    <Parameter id="SZu-8reYukK0EAK7-60LOg" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="nGxKxQBr-kyi7cNxQmpimA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="ulP3pO_Ur0K-aYiXu6yJOA" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="RoB18J8RPUK5FpXR1dZ5PQ" dim="Length" quantityType="0" />
-                    <Parameter id="S3gDQP4g_UC1N5leZiNPDA" name="pH" description="pH" persistable="0" isFixedValue="0" formula="n1_XMBec4Ei01McBGkAoRQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="GZKjHHiZpka0fsZIiUw8bg" name="Microvilli factor" description="Microvilli factor" persistable="0" isFixedValue="0" formula="kSwRisawq06FLjsXe5HRIA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="5yhI4Xzx_EOw5N6ns2yawQ" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="Y49UfJ1n7U2WOI-nHk-svw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="bhNnM2sMUUypJGgjHctMZQ" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" formula="YWludcb1S06qmG-IYInxDw" dim="Length" quantityType="0" />
-                    <Parameter id="FRrhuBXRrEGq8qftZdTymg" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" persistable="0" isFixedValue="0" formula="xlLTE_ZUtE6I0Ij_j7dc0w" dim="Fraction" quantityType="0" />
-                    <Parameter id="WueRfWdq6k24cGL7iVl-lA" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="6VVH7CXfUEW0zmAYA6JudQ" dim="Length" quantityType="0" />
-                    <Parameter id="cqbR-w3x8ECkX0Z6e4V0qA" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" formula="L6umBJ6TbUerJzF4Rwx9ow" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="B3a9sqHNak-L-uc29OSH0w" name="Intestinal transit rate" description="Transit rate along intestinal segments" persistable="0" isFixedValue="0" formula="F1NfQ7SpP0SOhjfi1jtbig" dim="InversedTime" quantityType="0" />
-                    <Container id="8o349omOdEuHRthuzqT3mQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Tags>
-                        <Tag value="MoleculeProperties" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="MHfPnKpXuE-yRQODFP-crw" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="yeoNyYv-9kKpFd7L7GTLvg" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="PBo5Qvwz4EecWM0_a7Fj0Q" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="yDipozXBVEKqwhBd0FGS7Q" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="LLrDAETmU06Llv8NRjevBQ" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" persistable="0" isFixedValue="0" formula="bB9_5HI4yEKcvea4m0-7ug" dim="Amount" quantityType="0" rHSFormula="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_colasc" />
-                        <Parameter id="0IryvnHWMEuYrtlxws96nw" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="m7iCmiRnmkSAWYlifPIPjQ" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="CJw9wL3u4kG7r8JfUKMa1A" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="Bq6ek8I7G0eXOjIkag47mQ" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="PWhYarNm5UqgrDsOKXQjlA" name="Solubility" description="Solubility" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_IntestinalSolubility" dim="Concentration" quantityType="0" />
-                        <Parameter id="5IV11DtxeU6RoY03sooC-w" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="qWWWR8Z2xU-q7SfElRW7Ww" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="XOYkQy77QkOYgpivTBoB2A" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="gmRLlQ3qEE-2HZWdcJBbcQ" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="bX43tNLOf0Gf5u2e9PVyyg" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="yRUS7B0pW0KvMV_2dJGzjg" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" dim="Dimensionless" quantityType="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="0VK_KFeZDUK2wXtt8tiCFw" name="ColonTransversum" description="Colon Transversum" icon="ColonTransversum" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="ColonTransversum" />
-                    <Tag value="Lumen" />
-                    <Tag value="LumenSegment" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="xvvYYnMJ6UunIYetA-751g" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_InverseLITT_Factor_ColonTransversum" dim="InversedTime" quantityType="0" />
-                    <Parameter id="fArAdl5iHkq810yeSymf5Q" name="Absorption of liquid" description="rate of liquid outflow" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_Outflow_ColonTransversum" dim="InversedTime" quantityType="0" />
-                    <Parameter id="3OS0psog9kGCLjng0KU7dA" name="Distal radius" description="Distal radius of intestinal segment" persistable="0" isFixedValue="0" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R2" dim="Length" quantityType="0" />
-                    <Parameter id="yrjjleCuuk6u7wycC0czZA" name="FillLevelFlag" description="Fill Level Flag" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_FillLevelFlagFlag" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="Ic_Hqr8M10ielvkj6zQKSQ" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_FillLevel" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="CWor2yr7okODk-5zmuD-zQ" name="Length" description="Length" persistable="0" isFixedValue="0" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Length" dim="Length" quantityType="0" />
-                    <Parameter id="agSWdeM6L0yY03wJasVISQ" name="Geometric surface area" description="Geometric surface area of GI segment" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_Area" dim="Surface" quantityType="0" />
-                    <Parameter id="I3H0CNPYDkGLBgBpwmJ8ug" name="Liquid" description="Liquid" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_Liquid_StartValue" dim="Volume" quantityType="0" rHSFormula="Lumen_PKSim.LiquidRHS_coltrans" />
-                    <Parameter id="UEOLiJTSSUCcMaaOUTORvQ" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_LiquidTransferRate_coltrans" dim="Rate" quantityType="0" />
-                    <Parameter id="I8GnAUwWk029xargFpvo7Q" name="Proximal radius" description="Proximal radius of intestinal segment" persistable="0" isFixedValue="0" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R1" dim="Length" quantityType="0" />
-                    <Parameter id="2Ti0Raru2USXqg74pOkLdA" name="Secretion of liquid" description="Rate of liquid inflow" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_Inflow_ColonTransversum" dim="Flow (volume)" quantityType="0" />
-                    <Parameter id="GTkYSfsShkavurws0weLZw" name="Thickness of gut wall" description="Thickness of Gut Wall" persistable="0" isFixedValue="0" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Thickness" dim="Length" quantityType="0" />
-                    <Parameter id="FjTDd6a0DEWmPZ7C3FYE3A" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_LumenSegment" dim="Volume" quantityType="0" />
-                    <Parameter id="BoKS56E2IEGPmcCF3VnVig" name="Volume (gut wall)" description="Volume of the gut wall" persistable="0" isFixedValue="0" formula="MucosaVolume.PARAM_VolumeGutWall" dim="Volume" quantityType="0" />
-                    <Parameter id="byCNpRNmNUWZVNGbD5khLQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                    <Parameter id="oxA91U_qWESKLyApG9Y8CQ" name="Intestinal transit rate" description="Transit rate along intestinal segments" persistable="0" isFixedValue="0" formula="6Sggk6E7dkiGHAy9VC_5CA" dim="InversedTime" quantityType="0" />
-                    <Parameter id="7_GtxnS_QkC6XJq4Mss_Ig" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" persistable="0" isFixedValue="0" formula="SXtF7gf8fUSFMw34Tk479g" dim="Fraction" quantityType="0" />
-                    <Parameter id="A7kzaCI6R0q7Ws86QEVYVA" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" formula="9F6otaV5SUK20OIuvTC-vQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="M2JPslW3-0uwajp4wBSQTA" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="PF5cf0mdnkOYmasSOYX-dA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="R5Qla9mjmU67Lo5OZutz7A" name="Microvilli factor" description="Microvilli factor" persistable="0" isFixedValue="0" formula="Sp6lJUufPEuMVly3sDkc3g" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="QlXyK3w2t0OE_bLFs6ZeUw" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" formula="AHCj7SYZNEWXxff-wcBdBA" dim="Length" quantityType="0" />
-                    <Parameter id="ywN51qrDfUyqbSnDktioUw" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="xVHmQeqFiUW9fC27fVHyQg" dim="Length" quantityType="0" />
-                    <Parameter id="sjz1ugcfKEGXlUmN-oTC_Q" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" formula="jq_ZatZ-0E2Pf5okfNks8Q" dim="InversedLength" quantityType="0" />
-                    <Parameter id="X_1dBEWMF0KkUoEL6xY1iA" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" formula="dKOyVtfUF0q4kvXAESIuUA" dim="Length" quantityType="0" />
-                    <Parameter id="ucZIPOBPk0Cl_4nm_Kcm6Q" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="42f7qMn0XUug8ZVdzgbOcA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="a2D303tF_kOw2C4UhW-a_w" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="zGfcMP9XHkSDtU03HHKatQ" dim="Length" quantityType="0" />
-                    <Parameter id="RBb0Ij9ze0i22O-pw7UlWg" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="ZKVkmbSPF0-h7-L6YerKbg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="k51BPulAY0qJO5g5OFS1_Q" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="ZmEs9XBx_Em29xo5ojyOZw" dim="Length" quantityType="0" />
-                    <Parameter id="duNcQZab3EGDuQL3CmwWTw" name="pH" description="pH" persistable="0" isFixedValue="0" formula="u0jYGpkjtEuSb8vlF3IKQA" dim="Dimensionless" quantityType="0" />
-                    <Container id="q8FeYx8pEE-0mrqN6JuKFg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Tags>
-                        <Tag value="MoleculeProperties" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="weE833256kaEu4ttrbxQtQ" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="mSsuvIcbgUyqSvFC6JwL3g" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="RXe2Q35w-kGg4A84t6YVWA" name="Solubility" description="Solubility" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_IntestinalSolubility" dim="Concentration" quantityType="0" />
-                        <Parameter id="IteCebUBiE-EJhHx_-WkTQ" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="QtVeRSwTsU-NJfLSbdRnwg" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="HLAe0EMD2k-07wfx_PdN2w" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="IS-3eWrA_ES6SyUFdaTSXA" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="DsKx3geN406kFno3c_tI0g" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="sgzIlgZQGUGq_GAiw8r_6Q" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="3p4vMZFbOkmsooXM7tkR2w" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="ABxG2Z4FjkWV-pO4c-GJDw" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="YxJBgb-oo0axFZItr44VaQ" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="NwFMRv0xhUyDrVo16OITEQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="g5poWcAdBUepTp9Jh1Bw1A" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="yZKFEegVNUyf7Fdt2k2BTA" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" persistable="0" isFixedValue="0" formula="X2Z_oXx_QEWPB3GzPJAgSw" dim="Amount" quantityType="0" rHSFormula="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_coltrans" />
-                        <Parameter id="UGYD7Kg6SEeGRkGuvKOCjw" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" dim="Dimensionless" quantityType="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="hCfl5QSnmkScQGM_92IC7A" name="ColonDescendens" description="Colon Descendens / Distal Colon 1" icon="ColonDescendens" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="ColonDescendens" />
-                    <Tag value="Lumen" />
-                    <Tag value="LumenSegment" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="fSXavtrobUe8qn9y9uQFaA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                    <Parameter id="Nn-Nk574BESf5vsJCEuZRA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_LumenSegment" dim="Volume" quantityType="0" />
-                    <Parameter id="Uhl-rUTCSUuzagBRd5gYnw" name="FillLevelFlag" description="Fill Level Flag" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_FillLevelFlagFlag" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="G073qarhvE65KAjZj8alkQ" name="Volume (gut wall)" description="Volume of the gut wall" persistable="0" isFixedValue="0" formula="MucosaVolume.PARAM_VolumeGutWall" dim="Volume" quantityType="0" />
-                    <Parameter id="gh_-e34lxk2P6YYC1BfeyQ" name="Distal radius" description="Distal radius of intestinal segment" persistable="0" isFixedValue="0" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R2" dim="Length" quantityType="0" />
-                    <Parameter id="2Cwf6Oqk6kOH5Nu9q2tVMA" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_FillLevel" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="vwl17z3tMkyVVhuGErgx-A" name="Geometric surface area" description="Geometric surface area of GI segment" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_Area" dim="Surface" quantityType="0" />
-                    <Parameter id="QZEFY-BuvUaSho2p8aT6xQ" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_InverseLITT_Factor_ColonDescendens" dim="InversedTime" quantityType="0" />
-                    <Parameter id="e_MvkoX--0-SG2SdiiAhjQ" name="Length" description="Length" persistable="0" isFixedValue="0" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Length" dim="Length" quantityType="0" />
-                    <Parameter id="PmtBuFojoUq4c-5_tw1woQ" name="Liquid" description="Liquid" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_Liquid_StartValue" dim="Volume" quantityType="0" rHSFormula="Lumen_PKSim.LiquidRHS_coldesc" />
-                    <Parameter id="IOJNpfvf9EKNzjCI40ymiQ" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_LiquidTransferRate_coldesc" dim="Rate" quantityType="0" />
-                    <Parameter id="1wTctDitSkaPmK9l-7Pb6w" name="Proximal radius" description="Proximal radius of intestinal segment" persistable="0" isFixedValue="0" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R1" dim="Length" quantityType="0" />
-                    <Parameter id="Dhv2is1a6E-lHHU_OQaQ2Q" name="Secretion of liquid" description="Rate of liquid inflow" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_Inflow_ColonDescendens" dim="Flow (volume)" quantityType="0" />
-                    <Parameter id="OY00alG3K0iyVvKT2TrTRg" name="Thickness of gut wall" description="Thickness of Gut Wall" persistable="0" isFixedValue="0" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Thickness" dim="Length" quantityType="0" />
-                    <Parameter id="I-inAVzDwUuF_xVAyWRr5w" name="Absorption of liquid" description="rate of liquid outflow" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_Outflow_ColonDescendens" dim="InversedTime" quantityType="0" />
-                    <Parameter id="9lgUx2rRIEaqIr8qx7alig" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="hSbBSKhBhUCaUPzgLzIR8w" dim="Length" quantityType="0" />
-                    <Parameter id="M8FSLdPfIUidwTQMBakxew" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" formula="yu6qaBDzFEmwe9K9kvVsYA" dim="InversedLength" quantityType="0" />
-                    <Parameter id="8QRw6BZ0U0qGjSN5W1Tx3Q" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" formula="IhJuF1VTBUiwrv3ceVgrIQ" dim="Length" quantityType="0" />
-                    <Parameter id="hIcnP1VLjE6jcSvUw0MOJw" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" formula="Zb46k_rqKUGzNgwt_88aYA" dim="Length" quantityType="0" />
-                    <Parameter id="N6bwWgvYEUC35SN2Lfrz9Q" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="xtsxA4pDO0qyM0cGcoLRLw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="4hY0inTGlkSQhELQEAktSA" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="6_saK5t3OEm84CNK1zAf8g" dim="Length" quantityType="0" />
-                    <Parameter id="-Imtw5QxeEK-RQfWMZHzzw" name="pH" description="pH" persistable="0" isFixedValue="0" formula="5-4QPgdyhUiHEzVHRvkIXw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="3WlNtYG0nUuzRRydwGpafQ" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="rppCWtkMdkOusICmBW81ig" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="L8av0keqUkObzLOmvHp05w" name="Microvilli factor" description="Microvilli factor" persistable="0" isFixedValue="0" formula="POZ59qSxIEio3S6sWEKERg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="UOnLlbCbKUm4Y1LB6n5gUw" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="2at4ymKkUEaudtLDHhU0qg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="G8BdVcQoJ0y5d-pXyiLT8Q" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="Tam_wgaEAkevbsPXdc1k3Q" dim="Length" quantityType="0" />
-                    <Parameter id="_ncj_4yYhE-RsnSKiLVHiA" name="Intestinal transit rate" description="Transit rate along intestinal segments" persistable="0" isFixedValue="0" formula="nSx2J2drlkacUpnynBUUaw" dim="InversedTime" quantityType="0" />
-                    <Parameter id="ZS2wegJpYEKEXEyzNj2oAQ" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" persistable="0" isFixedValue="0" formula="vOJV250J20uW5vElc_h85Q" dim="Fraction" quantityType="0" />
-                    <Parameter id="U5JhbrjB60uFlycWJy9JUA" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" formula="lnkwgBqoc0Cl1O0BddJXDw" dim="Dimensionless" quantityType="0" />
-                    <Container id="D7QkzvUIe0OkllGYXwXLVA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Tags>
-                        <Tag value="MoleculeProperties" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="Ozb5b24K9kCV9rqGpBeE-g" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="hxE9ckWx-0yUBT2FlXgpsQ" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="xK8fiz_IHkOu68C2Z_edeQ" name="Solubility" description="Solubility" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_IntestinalSolubility" dim="Concentration" quantityType="0" />
-                        <Parameter id="12tFPcj8XU2s4LbfyZlNVA" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="yemoD_cGzECxR57A4q8yQw" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="f-a6_wftpkK1gV9ilFTcBQ" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="b6-4gDH7TkCpK-O52UV-Kw" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="RGoN-vLZDkK0ZTq-Jx0fSw" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="R2Od_C2OZ0-DUVoUYtr0LQ" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="EKypVkeTpEusNpcn_hDTHg" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="lJ6nrRCjuEiHwNYgVHRZvw" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="OdYF50QF9UaPgXz554_zmA" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="igiwbJRCNkuVcbFuFmznSA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="9j-jfBD6aUajPfzUQ9aVBw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="VK_NjbqH7Uqa5zJ5kYx66Q" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" persistable="0" isFixedValue="0" formula="07L5RmsKfEyG4_QwjjMdGQ" dim="Amount" quantityType="0" rHSFormula="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_coldesc" />
-                        <Parameter id="cTNXjPf05kSASplc03WdBw" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" dim="Dimensionless" quantityType="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="Bi4ZMIHKqEWJTZaSDxNssw" name="ColonSigmoid" description="Colon Sigmoid / Distal Colon 2" icon="ColonSigmoid" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="ColonSigmoid" />
-                    <Tag value="Lumen" />
-                    <Tag value="LumenSegment" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="HULT57LKz0qSINb2j1DS5A" name="Secretion of liquid" description="Rate of liquid inflow" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_Inflow_ColonSigmoid" dim="Flow (volume)" quantityType="0" />
-                    <Parameter id="r0b2M6QZFkm_kKNnjyL9ZQ" name="Absorption of liquid" description="rate of liquid outflow" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_Outflow_ColonSigmoid" dim="InversedTime" quantityType="0" />
-                    <Parameter id="V-nTCgScuUytwZBJeGnzqQ" name="Distal radius" description="Distal radius of intestinal segment" persistable="0" isFixedValue="0" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R2" dim="Length" quantityType="0" />
-                    <Parameter id="6vJs1AX5dU-4k7tGpbjcsw" name="FillLevelFlag" description="Fill Level Flag" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_FillLevelFlagFlag" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="OvnMSw70j0SDB5zqdUf0Kg" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_FillLevel" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="aJV9UpqXt0Khx01V5wMB2A" name="Geometric surface area" description="Geometric surface area of GI segment" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_Area" dim="Surface" quantityType="0" />
-                    <Parameter id="alhR3b52t0C2n6OGu5g2YQ" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_InverseLITT_Factor_ColonSigmoid" dim="InversedTime" quantityType="0" />
-                    <Parameter id="TbG6LcdjFUSqei5Q_RXRtw" name="Length" description="Length" persistable="0" isFixedValue="0" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Length" dim="Length" quantityType="0" />
-                    <Parameter id="gIWTbJ1YK0yuCUSNC_8O7g" name="Liquid" description="Liquid" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_Liquid_StartValue" dim="Volume" quantityType="0" rHSFormula="Lumen_PKSim.LiquidRHS_colsigm" />
-                    <Parameter id="bL403AwWfECtvL5uOHarmg" name="Proximal radius" description="Proximal radius of intestinal segment" persistable="0" isFixedValue="0" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R1" dim="Length" quantityType="0" />
-                    <Parameter id="MM6bnPvGIUO1eb9x8k7E4Q" name="Thickness of gut wall" description="Thickness of Gut Wall" persistable="0" isFixedValue="0" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Thickness" dim="Length" quantityType="0" />
-                    <Parameter id="fzWVsn5O_ECTL8Iz93xH2w" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_LumenSegment" dim="Volume" quantityType="0" />
-                    <Parameter id="vpBIjzcHoUK9bXQqj4Zwyg" name="Volume (gut wall)" description="Volume of the gut wall" persistable="0" isFixedValue="0" formula="MucosaVolume.PARAM_VolumeGutWall" dim="Volume" quantityType="0" />
-                    <Parameter id="H2uuAna7TUeh0tdX5v4FjA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                    <Parameter id="3v-M6mbt6kCSY3tREKrxjA" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_LiquidTransferRate_colsigm" dim="Rate" quantityType="0" />
-                    <Parameter id="YzVEJBDzCE2C2GX5W-zbmA" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" formula="qH3FRrKlM0-4lLDcdB5gaA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="l1ZOJhimVkODQOKc3wN9DA" name="pH" description="pH" persistable="0" isFixedValue="0" formula="fRxB8dND0EScQhkz6VID1Q" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="4cusjM7nrE6gmjo-sPj4rg" name="Microvilli factor" description="Microvilli factor" persistable="0" isFixedValue="0" formula="17Ft4--dAEWiiBFika8rsg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="1kEDT7CO6EGQwCGWxUxx-Q" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="BdLu60sf5Eep_UpoM3lfAw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="sPZLRKNz5EuEf0u0hxR1ZA" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="Yh2pXCdcs0aa-d9CtznE_A" dim="Length" quantityType="0" />
-                    <Parameter id="p2A9L4a7sE-xZ3DVxbMwjw" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="i3a9cdJeMEuyCjeDd5_akQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="pWbHdUv4F0q-cycuCvwaMA" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" persistable="0" isFixedValue="0" formula="usECLvc1CkKSv6aHTIu5sQ" dim="Fraction" quantityType="0" />
-                    <Parameter id="xQK0IeMAs0OVW2YwbGHAGA" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="UvPZ_9QoD0arBxrDtj1yXw" dim="Length" quantityType="0" />
-                    <Parameter id="ANY-fy4Wbk2w9pQ7WfkVTw" name="Intestinal transit rate" description="Transit rate along intestinal segments" persistable="0" isFixedValue="0" formula="QSEA8AY9aEuk71cfyxWxgw" dim="InversedTime" quantityType="0" />
-                    <Parameter id="yOMuPyZ0iEGf-_TdSUGbqg" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="LgYe_t9Xe0GiCHKyujBD6Q" dim="Length" quantityType="0" />
-                    <Parameter id="MCcOTGqIe0iIFBlY27Vo5g" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" formula="l1sJKQUo_ECDj04QYqGsOQ" dim="InversedLength" quantityType="0" />
-                    <Parameter id="zHF0Qs8bFkmDoy7RFwlKrQ" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" formula="4SQEfNB64UKIL-EvrcGbgg" dim="Length" quantityType="0" />
-                    <Parameter id="AFTvzhW3h0KIVLTpdAscyQ" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" formula="zYBcbKXNxUaEgM5Yn5zmkg" dim="Length" quantityType="0" />
-                    <Parameter id="oBykzw9fHUClpmcmaHddXg" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="EkLwKQ8tLkq3JKlTDDNovg" dim="Dimensionless" quantityType="0" />
-                    <Container id="CzVjj5a-_E-M2PXAjoE4Xg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Tags>
-                        <Tag value="MoleculeProperties" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="L6mWeONz9Eapam2S6ZTIQQ" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="NazvjCtrGU-MXm--gaWLWQ" name="Solubility" description="Solubility" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_IntestinalSolubility" dim="Concentration" quantityType="0" />
-                        <Parameter id="pNzjThrXW0KVw9vgam-_7Q" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="lq9J9b_23USxCjPwU7Th0Q" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="dIQk-JoHL0mfQE4EOHYaaQ" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="TikJZSX-l0u_qqgF8JtcVQ" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="hOTmj3Q2AkCvdmN6ZyNOFg" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="3LflJMGqX0qtWHwp8OIJHA" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="O-_rkoESE0SeHmtyGudhYQ" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="6paoGrKzwEWqotHLN8DKRw" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="A1Yhvd00QE6EZLrFgUAanw" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="uMShzFFqx0uG9vcoESPr2A" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="iW6al8T3xE6yZnGj33ogMA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="MpWqsLanWkipkA203h_ouw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="1BYKg4TJPkeYk2ka4yv2Tg" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" persistable="0" isFixedValue="0" formula="0h-EbXrbvES8W4ElqdJsng" dim="Amount" quantityType="0" rHSFormula="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_colsigm" />
-                        <Parameter id="0f0eAl1GUEy4iSSz2jpBPw" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" dim="Dimensionless" quantityType="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="BSo2lLHrCkGHE23rSU5SRw" name="Rectum" description="Rectum" icon="Rectum" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Rectum" />
-                    <Tag value="Lumen" />
-                    <Tag value="LumenSegment" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="qMIol1FG4kGpoqrQAO328Q" name="Geometric surface area" description="Geometric surface area of GI segment" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_Area" dim="Surface" quantityType="0" />
-                    <Parameter id="peK5wLJrQUCsSFUNUyTUnw" name="Absorption of liquid" description="rate of liquid outflow" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_Outflow_Rectum" dim="InversedTime" quantityType="0" />
-                    <Parameter id="7Ght5NaU1kmBOGecI5xr0w" name="Distal radius" description="Distal radius of intestinal segment" persistable="0" isFixedValue="0" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R2" dim="Length" quantityType="0" />
-                    <Parameter id="1rwAmrQrBkK4SQLg1A4CaA" name="FillLevelFlag" description="Fill Level Flag" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_FillLevelFlagFlag" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="PZ3sgFVXqEqrePSIa4bUdQ" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_InverseLITT_Factor_Rectum" dim="InversedTime" quantityType="0" />
-                    <Parameter id="eznmgP8cf0emt9BHpsQV7Q" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_FillLevel" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="5k7HBPsJ7UyaMm4zUqhFRQ" name="Length" description="Length" persistable="0" isFixedValue="0" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Length" dim="Length" quantityType="0" />
-                    <Parameter id="h3EtXTLyp0OKhhpj6Tz7vw" name="Liquid" description="Liquid" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_Liquid_StartValue" dim="Volume" quantityType="0" rHSFormula="Lumen_PKSim.LiquidRHS_rect" />
-                    <Parameter id="8qQ4xdCdDE6p49xzKdW7ZQ" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_LiquidTransferRate_rect" dim="Rate" quantityType="0" />
-                    <Parameter id="zOAnUWDri0a5wqAzpZ5qnw" name="Proximal radius" description="Proximal radius of intestinal segment" persistable="0" isFixedValue="0" formula="Lumen_Geometry.PARAM_Lumen_Geometry_R1" dim="Length" quantityType="0" />
-                    <Parameter id="eqBMTCD8IkKPVHQWe2eUTw" name="Secretion of liquid" description="Rate of liquid inflow" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_Inflow_Rectum" dim="Flow (volume)" quantityType="0" />
-                    <Parameter id="mtqjMpTe306A_UR7977LdA" name="Thickness of gut wall" description="Thickness of Gut Wall" persistable="0" isFixedValue="0" formula="Lumen_Geometry.PARAM_Lumen_Geometry_Thickness" dim="Length" quantityType="0" />
-                    <Parameter id="d6hneZImh0a8vzEFSpalkQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_LumenSegment" dim="Volume" quantityType="0" />
-                    <Parameter id="aXd7vF4DBkajKPwTmElLJA" name="Volume (gut wall)" description="Volume of the gut wall" persistable="0" isFixedValue="0" formula="MucosaVolume.PARAM_VolumeGutWall" dim="Volume" quantityType="0" />
-                    <Parameter id="sIWF8lhj_0-wsnB_4BQutA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                    <Parameter id="giZ2lwSENk-ohCLMi54NKQ" name="Intestinal transit rate" description="Transit rate along intestinal segments" persistable="0" isFixedValue="0" formula="SclHDJFrI0uGg4PzXZQDcw" dim="InversedTime" quantityType="0" />
-                    <Parameter id="YVbkmNlDi0m6cLnYupueIw" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="cr9bhaNC50-P49rAY9iKIA" dim="Length" quantityType="0" />
-                    <Parameter id="DF31Cr3p6USez9bX0kNvkg" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="krDdXCUyu0mF7bIBMC1DMQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="jspVunSHNUCpHxP761o5Jw" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="hVjEsJsa90mQ8kGq5ZD9XQ" dim="Length" quantityType="0" />
-                    <Parameter id="j2rMckFJlUexITKgp4E_lA" name="pH" description="pH" persistable="0" isFixedValue="0" formula="Czjlffo10EOsUMEyRopvHw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="GpKaedg8z0CbRehy50Phyg" name="Microvilli factor" description="Microvilli factor" persistable="0" isFixedValue="0" formula="cnOuRPqMCk-cEMo-8q4aXg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="j9STnX11lkCZb9lOcBtWTA" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="kY4NL8Rw6EazF2Jchn-0QQ" dim="Length" quantityType="0" />
-                    <Parameter id="paZQVoNHjECBjQiPWDeIzA" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" persistable="0" isFixedValue="0" formula="Ci5wiQ6bkkWp7psm6iFP5g" dim="Fraction" quantityType="0" />
-                    <Parameter id="GuB3xLKs9UagGr_ZOF2rRQ" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" formula="HRD1ipe8HUqEd5gPYALEEg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="PQaMizMHZkuHHDfMJFnOmg" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="G1txCHuMpkaMpMK8F549gw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="9FfWIgPEjEeiLM7kXbZJxg" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" formula="Mzm0eUIIN0Oz5UFWc4eIvg" dim="Length" quantityType="0" />
-                    <Parameter id="zHSQgs0pn02RFrCreRyjcg" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="kxNCuEKcnUG7JkvFl2SDqA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="IzwQ064A3EGeF0Y1PE0JxQ" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" formula="HnVbsNXU_UWKj6uyve8ACw" dim="InversedLength" quantityType="0" />
-                    <Parameter id="qSp7itX2ok2Wgyr0Ge_CcQ" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" formula="ntGU7synQUqRROI0_nSU4A" dim="Length" quantityType="0" />
-                    <Container id="QKzzcH-eqkK5HndcuFjTHg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Tags>
-                        <Tag value="MoleculeProperties" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="Zbhozd0uyECnR3tzgBbkCQ" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" persistable="0" isFixedValue="0" formula="cwbCWivnF0aiXPWerzPr-A" dim="Amount" quantityType="0" rHSFormula="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_rect" />
-                        <Parameter id="RO0UD9hx7kqJLsE6Um8z2g" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="SRl_kIbZSkegAgow3mceBg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="6lHOG_CGc0S9nl_xwPLAJg" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="t3dOcoHzOk2MloK0sqRSsg" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="VQb1oIv0BEaeoyTlbL59iA" name="Solubility" description="Solubility" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_IntestinalSolubility" dim="Concentration" quantityType="0" />
-                        <Parameter id="zaw5yI_y40WW3OqivLYZoQ" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K8" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="UZQi1QI7K0W83cw5CXp4gQ" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="KNYuOZdMGEaROF7dAYptsA" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="hduVI_-xAUWTxPy8cZ8sMQ" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="5kSdGeHnWkmlVYDsxieQnA" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="MxCKPFXlPk2B7jD3cDnXBg" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="Nhf2ETkAF02j0xPT9jTzAA" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="JV-MVNeRW0WwOT4Kulb9Cg" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="e9_vDMgWY0ShwO1PUgDC0Q" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="ejKqUAUJCky9UrvEjkzpqg" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" dim="Dimensionless" quantityType="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="7r-hCC6l_EqDsW0kbuL8tA" name="Feces" description="Feces compartment used to collect the fraction excreted of the compound from the instestinal wall into the gut lumen." mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Feces" />
-                    <Tag value="Lumen" />
-                    <Tag value="LumenSegment" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="Tqj83jVZXkePzjzejZWhKw" name="Liquid" description="Liquid" persistable="0" isFixedValue="0" formula="0TGo83W1QUKlf0PWC7e_wg" dim="Volume" quantityType="0" rHSFormula="Lumen_PKSim.LiquidRHS_fec" />
-                    <Parameter id="DoCht2jvmEm3GujtUPjJNw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="otIUcHmffkasT-d2aSJl3g" dim="Volume" quantityType="0" />
-                  </Children>
-                </Container>
-              </Children>
-            </Container>
-            <Container id="MNdX2umV5E2JxNJjuLR7_Q" name="Stomach" description="Stomach" icon="Stomach" mode="Logical" containerType="Organ">
-              <Tags>
-                <Tag value="Stomach" />
-                <Tag value="Portal Vein Supplying Organ" />
-                <Tag value="TissueOrgan" />
-              </Tags>
-              <Children>
-                <Parameter id="npDy0FUUvUeO7l9LMvVkzQ" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" formula="VascularEndoVolume.VOLUME_VascularEndo_sto" dim="Volume" quantityType="0" />
-                <Parameter id="WKbzavV0C0eiGiW3XX2ddg" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_f_cell" dim="Dimensionless" quantityType="0" />
-                <Parameter id="f6D_EGVmBU2pulZHTjTMkg" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_Q_from_Qspec" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="IM9fg6giyU6rIQ1PtYzNwg" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" persistable="0" isFixedValue="0" formula="1rjW1UKmUEmilQF_TO1ukA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="diYpkrdxvU6_CWbcTvha5g" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" formula="GDdmg-7ezUerbmn3n4WHHQ" dim="Density" quantityType="0" />
-                <Parameter id="TQhW6FzzWk6zoWXRfo8BiA" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" formula="5z1H1ttKIkurqfNGJYBLCA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="wzw8RfBWRUK79aUDJmupmw" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" formula="CiLwOy1QL067wWVRRlpjJw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="KDFe9SHgh0arOXlvp0ZTWA" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" formula="p25Q5JcWtECpwYuVkobz-A" dim="Nanolength" quantityType="0" />
-                <Parameter id="7xSlrKFSoU6n49BFGmuZfg" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" formula="iTDrvofcHEmwuDUMXBDXyw" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="CbsWZ9B4bUe3GvfyxwiWug" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" formula="ReV91-MB6ke4A_txq-upBQ" dim="Nanolength" quantityType="0" />
-                <Parameter id="GI68NYrheECYK2P8KtTQlA" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" formula="zl8nVhVFtEWfkg7qvwyG3g" dim="HydraulicConductivity" quantityType="0" />
-                <Parameter id="7YFkK8MK5UCacCevicB1XA" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" formula="8Qr9x7XuSkuaDTwk5g8neg" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="iJa0XY3a70W7i6EF6xekFg" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="1MHL4PYfN0e5fFbymPW02g" dim="Dimensionless" quantityType="0" />
-                <Parameter id="8MwaAb9Ee0CFSTBo6rnGgg" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="QvouSUOw3EKC-X5EAbw1DQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="150BZ-yl7EK6thdB0IvSDw" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" formula="Sr4lKEWKXEC4r2lGh7So4w" dim="Dimensionless" quantityType="0" />
-                <Parameter id="zBwRzM-4O0-XzskJsrk8jg" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="XTCnBSz3O0mjocJl2z4LmA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="okkkrIaAyUaS0SHkcyOdRQ" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="64CCbsYUoEOdZ6o-OnFrfQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="RrgUwN9vbEuHU4RlQ_ba1Q" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="Qs8KaPwuG0STV1LZrRtxtQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="qOgiGfSItE-7xEjKNwyHfA" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="fk2_34fv10GZJsu9du9g7w" dim="Dimensionless" quantityType="0" />
-                <Parameter id="-a04TSO_dkaDIR8EYmJTtg" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="b3M3OlTbWEuauLIxxnNrqQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="HPyzhWqCAkSwzVA8NiowfA" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="M7aQzSb8nE6Jaixxxlu0qA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="K2xy54yzBEC_l4AJc-G_bg" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="Mznm45MMv0GXdNndyd067g" dim="Dimensionless" quantityType="0" />
-                <Parameter id="KurG2vIlR0akYOUz384ePw" name="Microsomal protein mass/g tissue" description="Microsomal protein content per gram tissue" persistable="0" isFixedValue="0" formula="Bkj1S15qJEuCnwPbEZXl1A" dim="MassProteinPerTissue" quantityType="0" />
-                <Parameter id="pRdHXy-SWUetNgY00hMPtw" name="Number of cells/g tissue" description="Number of cells per gram tissue" persistable="0" isFixedValue="0" formula="Ci74Hnt_f0an864qZengMw" dim="CellQuantityPerTissue" quantityType="0" />
-                <Parameter id="4aLLxU88LUyYbPbi218SPQ" name="Protein mass/g tissue" description="Total protein content per gram tissue" persistable="0" isFixedValue="0" formula="pth_210YGEC8B88O0JHgyA" dim="MassProteinPerTissue" quantityType="0" />
-                <Parameter id="-Cv75CKJh0eRVr653IeukA" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" formula="NbYzw3-qYUK3NRzYa2m46w" dim="Dimensionless" quantityType="0" />
-                <Parameter id="ajrx1PxHo0an2N3iFXWXRQ" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="sL3k_D8OWUSmdQ1azhLeog" dim="Dimensionless" quantityType="0" />
-                <Parameter id="kokfeCEEmUW_O50zq8mbew" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="m2SMvUQbOE6khBGyZpubTw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="pkq7gQsm1U-ofUlyZjg3gw" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="vn6yNh1Wxk2sw-NkaEid9Q" dim="Dimensionless" quantityType="0" />
-                <Parameter id="y90WUPZr3USz-Pmn1V0Z8A" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="YntncCU9hkeBkFJ9kh27cQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="hDoMPQUhN0ev4UpOMrawEA" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="r6aT8k7i2EyN6OCtjIyyMw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="cBDB-5IpwU-cDWfaRPQqAg" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="AY3gtsbh_kuZ2N-vterJow" dim="Dimensionless" quantityType="0" />
-                <Parameter id="Vt30fwjWXEeJJhwZNfEwMA" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="5ZcpYt2ovE-TWo51C60ACg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="g5z4lFMXYUumGNNwGXtm1g" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="p-lUYwb5D0-CnicNMCag0g" dim="Dimensionless" quantityType="0" />
-                <Parameter id="l-K6L5tqgkCnfU9FmU51ig" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="8ZH0wFS0OUiKwyq6Codh8g" dim="Dimensionless" quantityType="0" />
-                <Parameter id="cbU0dm7Q4k6lEycs_AEwUg" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="dYNx5FHmY0WlqoWIWpxqNA" dim="Dimensionless" quantityType="0" />
-                <DistributedParameter id="7Ak-ZIC_h0e3AMs0gwUpRg" name="Volume" description="Volume of organ or compartment" persistable="1" isFixedValue="0" formula="Z9HBMbQrrEC0I0H9dexNnA" dim="Volume" quantityType="0" mode="Logical">
-                  <Children>
-                    <Parameter id="PJ9lCnMfD0aP8IJnbjSYoQ" name="Percentile" persistable="0" isFixedValue="0" formula="_dtleNaxRkKlfs1EsMKpOw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="r0esHpJ6GkO6ZBfxPmPGqg" name="Mean" persistable="0" isFixedValue="0" formula="9LAChuGH6U2TIsEotDLppA" dim="Volume" quantityType="0" />
-                    <Parameter id="Z6LYqtWlgkGmyYf_eu1DVg" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" formula="krZDAennLkmHh8J79XoWcA" dim="Volume" quantityType="0" />
-                  </Children>
-                </DistributedParameter>
-                <DistributedParameter id="4rIHMCBj4Ee7eSlEsmiWoA" name="Specific blood flow rate" description="Blood flow rate normalized to the organ volume" persistable="1" isFixedValue="0" formula="PRTAPOXIg0KxenodsPzfRA" dim="Flow (volume) per organ weight" quantityType="0" mode="Logical">
-                  <Children>
-                    <Parameter id="a1IHV6AEOkKkMblMKDgFQQ" name="Percentile" persistable="0" isFixedValue="0" formula="lD8UfZjjNEOWJbEq0cCSDA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="BTSphC7-a0mTxxIxHwXEjQ" name="Mean" persistable="0" isFixedValue="0" formula="J1sRsYvKa0Gdh-hr6w1J0g" dim="Flow (volume) per organ weight" quantityType="0" />
-                    <Parameter id="H1SSa7ybmkGlfGBaq-x7sQ" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" formula="BfLmmvm55EaN9KOQ-S_PXg" dim="Flow (volume) per organ weight" quantityType="0" />
-                  </Children>
-                </DistributedParameter>
-                <Container id="pVA-97xMJk2pIZRvafTI-w" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Plasma" />
-                    <Tag value="Portal Vein Supplying Organ" />
-                    <Tag value="Stomach" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="PUlpjrmQv0i-5sRsW2DsFA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                    <Parameter id="uaX8T4nwqUmdRApKTeLoyw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" dim="Volume" quantityType="0" />
-                    <Container id="2jMMqmMdLEewSB7bBeLMgw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Tags>
-                        <Tag value="MoleculeProperties" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="eLeR4wSLL0e8OtQlhNtQTg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" dim="Dimensionless" quantityType="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="6rJ8cqge0U28pltXPlJSGg" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="BloodCells" />
-                    <Tag value="Portal Vein Supplying Organ" />
-                    <Tag value="Stomach" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="6ekYsgZcG0O2Ra0AC_gvuw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                    <Parameter id="5M1XvqDrUUGSv37wrgmyNg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" dim="Volume" quantityType="0" />
-                    <Container id="t5UdOZYFkECHYvTdzk2tLg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Tags>
-                        <Tag value="MoleculeProperties" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="x8xgysPyBk-fYbBxKvyfSw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" dim="Dimensionless" quantityType="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="qy33QgWMT0asBh6M83zXDg" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Interstitial" />
-                    <Tag value="Portal Vein Supplying Organ" />
-                    <Tag value="Stomach" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="jmLBWSUmSEKlO1CVcJjXHw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                    <Parameter id="AeAnUG21wE2HlzO8GACPQw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" dim="Volume" quantityType="0" />
-                    <Parameter id="_Vaajljj9E2ojjp7jSALWQ" name="pH" description="pH" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_pH_INT" dim="Dimensionless" quantityType="0" />
-                    <Container id="78tMdgQv00-1cwtkQi6Kqw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Tags>
-                        <Tag value="MoleculeProperties" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="qOB77GAO0069v_97QcfenA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_sto" dim="Dimensionless" quantityType="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="HVHehptfYU29BpEja2I2vA" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Intracellular" />
-                    <Tag value="Portal Vein Supplying Organ" />
-                    <Tag value="Stomach" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="-aR68xrpDkS9-VWpLZpiLg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" dim="Volume" quantityType="0" />
-                    <Parameter id="SNUEBtifJUW9BHv6qab3Ug" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" dim="Volume" quantityType="0" />
-                    <Parameter id="TwgCiCPw-k6rGUjiqleohw" name="pH" description="pH" persistable="0" isFixedValue="0" formula="59sy97ovoEa00BvYV7Wmsg" dim="Dimensionless" quantityType="0" />
-                    <Container id="j0sWlniY80OBM1z8HclbpA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Tags>
-                        <Tag value="MoleculeProperties" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="tR-jMYe-DESCp1feF7vCqA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_sto" dim="Dimensionless" quantityType="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-              </Children>
-            </Container>
-            <Container id="G4MRDr6wnU-l5GflqsEPPg" name="SmallIntestine" description="SmallIntestine" icon="SmallIntestine" mode="Logical" containerType="Organ">
-              <Tags>
-                <Tag value="SmallIntestine" />
-                <Tag value="Portal Vein Supplying Organ" />
-                <Tag value="TissueOrgan" />
-              </Tags>
-              <Children>
-                <Parameter id="4tC2Y7GI0kaw5y62Vq8SSA" name="Small intestinal transit time factor" description="Small intestinal transit time factor" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_SITT_Factor" dim="Dimensionless" quantityType="0" />
-                <Parameter id="UApmYOxl9UiYmysnNVA_aw" name="Colon_Arrival_Time_Slope" description="Supporting parameter for calculation of colon arrival time" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_Colon_Arrival_Time_Slope" dim="Time" quantityType="0" />
-                <Parameter id="TwAT91WG1Ei7M5pKu6Ogzg" name="Colon_Arrival_Time_Intercept" description="Supporting parameter for calculation of colon arrival time" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_Colon_Arrival_Time_Intercept" dim="Time" quantityType="0" />
-                <Parameter id="REUX5bwTCkOAU3I1JBoM-g" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_Q_Lymph_sin" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="1yOwQoWQC0eOKurJNgVA-w" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" formula="VascularEndoVolume.VOLUME_VascularEndo_sin" dim="Volume" quantityType="0" />
-                <Parameter id="wP9HVrgnoEmDO1QZuGV3XA" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_FluidRecirculationRate_sin" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="3mmLxvOLdES7zYnFyRdYJQ" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_f_cell" dim="Dimensionless" quantityType="0" />
-                <Parameter id="YLWC7PafgUa2zfxZiic2qA" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_Q_from_Qspec" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="BgwNr4RoOU-3a5KMXUkH3Q" name="Volume (mucosa)" description="Volume of mucosa" persistable="0" isFixedValue="0" formula="MucosaVolume.VOLUME_SmallIntestineMucosa" dim="Volume" quantityType="0" />
-                <Parameter id="3SCDMG_qMkywpO8dAkC35g" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" persistable="0" isFixedValue="0" formula="-aJkWaOtK0-CYLedc8wpLQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="M_zC6lX0ukm7zbsoRqNrAw" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" formula="2kS59SdKzkqKAleeLQgoIw" dim="Density" quantityType="0" />
-                <Parameter id="qeb30ACp70iuciGsT1wYuA" name="Colon_Arrival_Time_Intercept_a0" description="Supporting parameter for calculation of colon arrival time" persistable="0" isFixedValue="0" formula="dkcNivxQckuLzb9rxvlAOQ" dim="Time" quantityType="0" />
-                <Parameter id="bjyCiBllbE-sEdjp2DhsXw" name="Colon arrival time" description="Colon arrival time" persistable="0" isFixedValue="0" formula="3p2YtlRXKkKF4TDdmGvaxw" dim="Time" quantityType="0" />
-                <Parameter id="_PCHIHMkJk2a9EyRQPDDsg" name="Mucosa blood flow fraction" description="Blood fraction which goes to mucosa" persistable="0" isFixedValue="0" formula="QOvbJZ6C9UG3MCC-ogfvcw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="oCbTp4cfUkCUh2A3kXx6Hg" name="Colon_Arrival_Time_Slope_a2" description="Supporting parameter for calculation of colon arrival time" persistable="0" isFixedValue="0" formula="gpVANoVJQEWLQyLMZnA4Gw" dim="InversedTime" quantityType="0" />
-                <Parameter id="FF6PyTuhFkOn3nlLmiS3Og" name="Colon_Arrival_Time_Slope_a1" description="Supporting parameter for calculation of colon arrival time" persistable="0" isFixedValue="0" formula="f6MPdqCATEyyg9BkPIM1fg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="Oyeygy4YTEC3G9YRv54u1A" name="Colon_Arrival_Time_Slope_a0" description="Supporting parameter for calculation of colon arrival time" persistable="0" isFixedValue="0" formula="NGZMfQJycki67-bJxhjmDw" dim="Time" quantityType="0" />
-                <Parameter id="CmOtFhq7aky6dAjAdFx55w" name="Colon_Arrival_Time_Intercept_a1" description="Supporting parameter for calculation of colon arrival time" persistable="0" isFixedValue="0" formula="cTogM5fsd0a_Qag8roUTSQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="dlSLL3JygECtOM7-YSnFLA" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" formula="jEigHwHnrkya7CGs_PtfBQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="YsLpvyO_U0Sp7PAqbHmuZw" name="Lymph flow rate (incl. mucosa)" description="Lymph flow rate (incl. mucosa)" persistable="0" isFixedValue="0" formula="Fjnom9eETkWZwSP2ItXeiQ" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="WMbUujB7GEaViCrrzmAIaA" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" formula="BVOU8c6M-UaToEt2NIvHmQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="kLj9T3LJnkenmMBcTowi2w" name="Fluid recirculation flow rate (incl. mucosa)" description="Fluid recirculation flow rate between plasma and interstitial space (incl. mucosa)" persistable="0" isFixedValue="0" formula="RTA7ucQRFUGOgfO4wDVh2Q" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="V-j8pulenE-j9wR3TU3Jhg" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" formula="I4rm7WNgVkupmPjrgCbesA" dim="HydraulicConductivity" quantityType="0" />
-                <Parameter id="CVjifgqV_E-ic7bLQvPYLg" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" formula="7Tug8gZu6E2UVV0CAi26YA" dim="Nanolength" quantityType="0" />
-                <Parameter id="-fpNNLfGf0-1URo_npqp2Q" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" formula="ZppG6rMzd0Ck_zz7tdtiEA" dim="Nanolength" quantityType="0" />
-                <Parameter id="T0gVQIPzPUakJG1fadifKA" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="3fhcZD6AG0CxBp8UiOx5xQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="JlE79EDgRUif-7gTXgxuCA" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="Oha5KMQ5bkKhXC9TwVIt-w" dim="Dimensionless" quantityType="0" />
-                <Parameter id="BiQaHyKWQ0qhCVPHOsEBRg" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" formula="7BjekycZ0kmjrOA1PUNZxw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="2B9lorrY0EOdjYLVeQ6d9A" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="bPUnmYJGH06_mOEVDCS_YA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="L3BM9lU-KkeNeePZ0ued6w" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="ZaA8B-jJ9kq3WD4a2DGf3A" dim="Dimensionless" quantityType="0" />
-                <Parameter id="_lG5tEEdUU27fxIc6tkbwQ" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="saFlbbNfckG-Gray_v9Gyg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="ND8bGXYzZEGZiQIyPjxkSQ" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="szhehiC9RUecSJ8-qGH7zg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="HUorJn64MkiFu1lUtPDeiA" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="wu1Oi4il3E-PA9XqhHkZGQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="7tZmxMiiB0m_CQlUdVR_YQ" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="vGSguVmDqkCB96uLIc1bEw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="4EyRT_ln00y8Ovm4q51fWw" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="id3Mf0LsXUCHp6Z_WxrfIQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="SfTsw03Q_UOzWO5hzLlAwg" name="Microsomal protein mass/g tissue" description="Microsomal protein content per gram tissue" persistable="0" isFixedValue="0" formula="iedx92PnHUOvTGB52CyEow" dim="MassProteinPerTissue" quantityType="0" />
-                <Parameter id="Opuga7Xb9EWnQHaPry62fA" name="Number of cells/g tissue" description="Number of cells per gram tissue" persistable="0" isFixedValue="0" formula="bXggTLEoSEKLtB13lwzq2g" dim="CellQuantityPerTissue" quantityType="0" />
-                <Parameter id="7TsIm0GLkEiAcjTM3ktofw" name="Protein mass/g tissue" description="Total protein content per gram tissue" persistable="0" isFixedValue="0" formula="WA7Cnkh-ek6r2Hb4wLdaDg" dim="MassProteinPerTissue" quantityType="0" />
-                <Parameter id="eU6pzkokK0KVmiO2qE9Qrw" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" formula="TXDHCiQEYEGV4dnq34hikA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="856BuZMXXESBhOlncrtc1w" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="vuDHmE94z0Oltl6EeztKMQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="IjVLegloO0yNNJgSv60lUw" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="6B01JYgh0Umf0-xQYyTNoQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="BPddtBOF5UC4abNPHxwVwA" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="X1nshlWzQkaJ81_9Xr_10Q" dim="Dimensionless" quantityType="0" />
-                <Parameter id="1yCsAMxhskOxgjr4LxnXww" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="QWG2xyJfuUCWvvDazUctQQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="k8VWPCD8LUSM_Eh8FaDZmg" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="rs-bmK5vwUurC8pro7MXog" dim="Dimensionless" quantityType="0" />
-                <Parameter id="Lt8fSaS2jU-CCF_b7YUJ3Q" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="zl2-_FCZ50OxXpa2FaoCYQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="EG7r-7_FGkOLkrlUL2bESw" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="5QnjSBmOO0myPBg2aT6uyA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="1un6a7u8vkuhds1FCLpBxQ" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="1zsoVHm5U0ayEl1-srrE5A" dim="Dimensionless" quantityType="0" />
-                <Parameter id="aYi3eXMg_EabVIVJLZKb0A" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="ojkPFrpmNUmSH1JD20b0lA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="uoVBgn_gv0avh-z8oQDh4g" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="osd4q3YDyEOq9SX1cCxe4A" dim="Dimensionless" quantityType="0" />
-                <DistributedParameter id="QDGnGA57-kazSeEpCVrvgA" name="Volume" description="Volume of organ or compartment" persistable="1" isFixedValue="0" formula="XlqvQEAwgkmYd9n0u_Asdw" dim="Volume" quantityType="0" mode="Logical">
-                  <Children>
-                    <Parameter id="OV09p22OWE2JYTWoaES4dA" name="Percentile" persistable="0" isFixedValue="0" formula="fxH7-hhDQk-MziGjVIMdjg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="4bqAzOzyakSwZF8LgwgxTQ" name="Mean" persistable="0" isFixedValue="0" formula="t2y-_GRHSkyPiDjB9b2x1Q" dim="Volume" quantityType="0" />
-                    <Parameter id="ejIic2FrVk6hsRtQutAgNg" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" formula="7e_MAqNDvk601b72g9UT2w" dim="Volume" quantityType="0" />
-                  </Children>
-                </DistributedParameter>
-                <DistributedParameter id="2pW5D90K8ESydFZTCMpdsA" name="Specific blood flow rate" description="Blood flow rate normalized to the organ volume" persistable="1" isFixedValue="0" formula="xxvRl5usgEOXeQ2BsjLTyw" dim="Flow (volume) per organ weight" quantityType="0" mode="Logical">
-                  <Children>
-                    <Parameter id="hX2_BeRXLU2XuPfx89E9cA" name="Percentile" persistable="0" isFixedValue="0" formula="7gNY3RDpyEuSRoDzNhcekQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="HFtZtsTt10aKtzXRCm1yJA" name="Mean" persistable="0" isFixedValue="0" formula="m6EXR2TeOkCWNWE183LEzA" dim="Flow (volume) per organ weight" quantityType="0" />
-                    <Parameter id="mBjq1iGGwk6B462isDyfbA" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" formula="EQrP2qSSXkuxERo8GtXJ8A" dim="Flow (volume) per organ weight" quantityType="0" />
-                  </Children>
-                </DistributedParameter>
-                <Container id="9bNBf7f5bECO2rVlpa9ohg" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Plasma" />
-                    <Tag value="Portal Vein Supplying Organ" />
-                    <Tag value="SmallIntestine" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="v2v-cXeaW0OaVj7TJKoqeQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                    <Parameter id="SLBzvaRX9kOwNmIGXIpgwg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_pls_SinLin" dim="Volume" quantityType="0" />
-                    <Container id="4NFFIQhpg0GBZdsYFMpSUQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Tags>
-                        <Tag value="MoleculeProperties" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="H2sozrmX7EuofdgCBnYTTw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" dim="Dimensionless" quantityType="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="aSoZ2sizDky7iyqNn7-KEg" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="BloodCells" />
-                    <Tag value="Portal Vein Supplying Organ" />
-                    <Tag value="SmallIntestine" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="nHfmnrAvRECWCFmdjSnfhw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                    <Parameter id="zlRoWroFtkuqa_6kc_FlTw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_bc_SinLin" dim="Volume" quantityType="0" />
-                    <Container id="drCRoiLLlE-H1eshcO26IQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Tags>
-                        <Tag value="MoleculeProperties" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="pKjGNopiVECznDt0NGcvGA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" dim="Dimensionless" quantityType="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="oqAJaFWZKki03c9kilSh2Q" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Interstitial" />
-                    <Tag value="Portal Vein Supplying Organ" />
-                    <Tag value="SmallIntestine" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="SJUOwnvLRk-weSMlPVXQ5A" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                    <Parameter id="lxxAQHhxGU6wjM8MNuiGuQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_int_SinLin" dim="Volume" quantityType="0" />
-                    <Parameter id="wdsjI1QD_UCUeE3xgq4tYA" name="pH" description="pH" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_pH_INT" dim="Dimensionless" quantityType="0" />
-                    <Container id="kEAFp8yw8UaRi4Y1t58kuQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Tags>
-                        <Tag value="MoleculeProperties" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="768NpIItakebj0m6BNuAWw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_sin" dim="Dimensionless" quantityType="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="ULhix8ymhkqjAN0AfH3VDg" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Intracellular" />
-                    <Tag value="Portal Vein Supplying Organ" />
-                    <Tag value="SmallIntestine" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="7Utu9-Vzv0KATDykgbdQ2Q" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ_SinLin" dim="Volume" quantityType="0" />
-                    <Parameter id="04frhqoBlUepCsczktAm-A" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_cell_SinLin" dim="Volume" quantityType="0" />
-                    <Parameter id="DqSPGNtpJESNpFApVF6V9g" name="pH" description="pH" persistable="0" isFixedValue="0" formula="bBdB5nDFL0ahHIkUa2uMzQ" dim="Dimensionless" quantityType="0" />
-                    <Container id="FEqDEAIQrUOYYbC8qW21zA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Tags>
-                        <Tag value="MoleculeProperties" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="EmBgnDJ2yEmATkJGOPoayA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_sin" dim="Dimensionless" quantityType="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="fk_P0310t0msyk3m0rCMeA" name="Mucosa" description="Mucosa" mode="Logical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Mucosa" />
-                  </Tags>
-                  <Children>
-                    <Container id="e-WGMhUwUEimDskcfHMAxQ" name="Duodenum" description="Duodenum" icon="Duodenum" mode="Logical" containerType="Compartment">
-                      <Tags>
-                        <Tag value="Duodenum" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="tCiTgcfo-k-t9MESW8Zvow" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="MucosaVolume.VOLUME_MucosaDuodenum" dim="Volume" quantityType="0" />
-                        <Parameter id="UjPeeAlLNEWPtjxG2azMOQ" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_J_iso_Mucosa" dim="Flow (volume)" quantityType="0" />
-                        <Parameter id="2f9zLv9hm0OeTGgl7WolGw" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_Q_lymph_mucosa" dim="Flow (volume)" quantityType="0" />
-                        <Parameter id="n0UrUmxCI0C6TZe5dQUzKA" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" formula="VascularEndoVolume.VOLUME_VascularEndo_duo" dim="Volume" quantityType="0" />
-                        <Parameter id="gRotjCsQm0ybQH3ZxftouQ" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_Q_mucosa" dim="Flow (volume)" quantityType="0" />
-                        <Parameter id="XInUnAiLS0-ansjxVrslGg" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_f_cell" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="Ue9afk2BI0WOnMTIBthj-A" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" formula="LAsSDCdLk024DOexMc5g2Q" dim="Density" quantityType="0" />
-                        <Parameter id="BkWrzaBeFUedUy4qxem47w" name="Fraction mucosa" description="Mucosal fraction of regional intestinal tissue mass" persistable="0" isFixedValue="0" formula="XVsXu3zLB0WV_XXPtX9Ucw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="qPT4G03M5kSi795EwwGIFA" name="Fraction of regional blood flow rate" description="Regional blood flow fraction supplying the mucosal tissue of the segment" persistable="0" isFixedValue="0" formula="rO5HKgPLNE2ded6C5j8iAA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="tqZ9YiXd4ES2CfO7ePQFJw" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" formula="BclPwCUpq06iPPKJxbiotA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="Tyr-0h3axkeA7x73NVu_Vw" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" formula="85Z_IitjNkqgtQRgsuZktA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="5g5fqm2mIkWYCFdcW0caHA" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" formula="Roc2snZHbkOj5D2A1-WNaQ" dim="HydraulicConductivity" quantityType="0" />
-                        <Parameter id="90pFeIBOZE2tZr5xjvwk0w" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" formula="Po9W_KLeBEK7pju6JZRT1A" dim="Nanolength" quantityType="0" />
-                        <Parameter id="ZmhrU9exR0myRWnye4evKA" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" formula="qw15H5MXDUO32xmpB_12qg" dim="Nanolength" quantityType="0" />
-                        <Parameter id="3B0D3a8nyEioC3S5BSdqoA" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="UObD2OZNm0aO6baZC3rL3w" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="gxAcpH_ft0y06Lc_c3sFKA" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="4fIos9dmDEubi7CfctK6Xg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="ydc0WzaEUEmU4MD0LxiXog" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" formula="dHyYqAXAYk2S-fhguCW4gQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="pEc9Cxv-CkKd2SW6QGTLWQ" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="j4Sj55jGYkOtf7IO4eQQwQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="NBSLwElKF0SKsd4p2MA3-w" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="OSMKmbW0kk6IINKJ9XUmYA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="C3WgxIrpXEiDJ2Tu5xDc_A" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="tl_ilfljiE2wJbGLPfrbnw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="yitYm2XjfkGhSS59cqnwpA" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="_tN8Evj7HkKuWO5bYIxP0w" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="qrNjBz7eukCZIhqp6CMrtQ" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="XDiIbYdn4kO91U5t6jTgpw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="m6zBvn9srkGo34HCMMg8Hw" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="qTo9GVcQM0mrktfG8RnFxA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="K86GEyNuREmU6X5BnWrnXQ" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="iwtHnSpzYkWsZpZvGlHIJg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="5Moj6KhOUUmLNDJWKxlH2g" name="Microsomal protein mass/g tissue" description="Microsomal protein content per gram tissue" persistable="0" isFixedValue="0" formula="N43kcuPPkUqx22frHHbf4g" dim="MassProteinPerTissue" quantityType="0" />
-                        <Parameter id="5XGj59lJ9kOA46-_2-iCyg" name="Number of cells/g tissue" description="Number of cells per gram tissue" persistable="0" isFixedValue="0" formula="6ZvwQ2eaIUedMjm-PHSW3w" dim="CellQuantityPerTissue" quantityType="0" />
-                        <Parameter id="GdCOFw6Nvka5g9Yn0YRNaw" name="Protein mass/g tissue" description="Total protein content per gram tissue" persistable="0" isFixedValue="0" formula="-Z06QV5wk0OERpeSYuaquw" dim="MassProteinPerTissue" quantityType="0" />
-                        <Parameter id="ymGWGCC9bE2YrvKFu9k3XQ" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" formula="_-Hc7hTgKUOftvx6U3MzfQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="QVLx5FGJJEiiJ1UPhWmY6Q" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="5WrHCXCcgkeS0uqWneEMZA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="yiLd1yI4iE2Ur5vNxcriGw" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="kCOJ7uCzzEaTo5tgm4dJvQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="1hjQ-weWD0uZjKRXkl1Ueg" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="48hUov7L402lNxkOuwQMBw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="HBsJF28fv0aHwfiwSsG4Hg" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="PmABekPJ50OWVbxZ023Lnw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="17oJNWR830OaPbkke1MpbA" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="7ij9wpas80CxaglO4oD9sw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="C3RJ70cizE65-zCbhx7Umw" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="HowlSNtHI0Wmd_-A65vJuQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="1B__Pcs33UKwvcG3wnZ3Yw" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="iVVyfycQdkiVIfvBxzafZA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="5OHDAHfD-Ue7qUoGuutWUg" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="7xjqrWepOEm_VtZFkYSK5w" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="BjXm69O-hESyHtz4ym4QIA" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="PMi_CtD9bkmCHaxoQivNjw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="auTBRP06vECchWNR-h1FsQ" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="swolLOWRJEeBQJhEL6AQUA" dim="Dimensionless" quantityType="0" />
-                        <Container id="Uw8BHY6NWESXphEVCwU2-Q" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Plasma" />
-                            <Tag value="Duodenum" />
-                            <Tag value="Mucosa" />
-                            <Tag value="SmallIntestineSegment" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="ESjC39dQD0aI7611jqq2Qg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                            <Parameter id="sHhlgjKTtkiz_oXsqRTcrQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" dim="Volume" quantityType="0" />
-                            <Container id="4uny8V2gtkaO_7wubpovXg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Tags>
-                                <Tag value="MoleculeProperties" />
-                              </Tags>
-                              <Children>
-                                <Parameter id="gE0pBDtOhUGygL-9oj89TA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" dim="Dimensionless" quantityType="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="pkv5-3lim0ytLpaYYc02Bg" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="BloodCells" />
-                            <Tag value="Duodenum" />
-                            <Tag value="Mucosa" />
-                            <Tag value="SmallIntestineSegment" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="YLzH5fGKHE-hRYwP8hiGQQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                            <Parameter id="wcRvcc4zHEuESVGHEaVCKQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" dim="Volume" quantityType="0" />
-                            <Container id="VlYGX3EA7U6Q2dXTc_eBSQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Tags>
-                                <Tag value="MoleculeProperties" />
-                              </Tags>
-                              <Children>
-                                <Parameter id="mmv6v_yB2kKFzBidaROf0g" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" dim="Dimensionless" quantityType="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="mQNOnFI5gkWapmSPOH2IGQ" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Interstitial" />
-                            <Tag value="Duodenum" />
-                            <Tag value="Mucosa" />
-                            <Tag value="SmallIntestineSegment" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="kK5S7DuoHECT88vHE4Td2Q" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                            <Parameter id="sV3Yx7YD20m9dZNV4ugJ8Q" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" dim="Volume" quantityType="0" />
-                            <Parameter id="eM2X4EjU2Eu-o5QNDIpMYA" name="pH" description="pH" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_pH_INT" dim="Dimensionless" quantityType="0" />
-                            <Container id="ezqxrVN2kE6cuFn1uAlT6Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Tags>
-                                <Tag value="MoleculeProperties" />
-                              </Tags>
-                              <Children>
-                                <Parameter id="ieu-njmrnE-vPhFpWTqDjw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_duo" dim="Dimensionless" quantityType="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="Ky1ukmcECUWZ1yd2GXs5Yg" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Intracellular" />
-                            <Tag value="Duodenum" />
-                            <Tag value="IntestinalSecretionSource" />
-                            <Tag value="Mucosa" />
-                            <Tag value="SmallIntestineSegment" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="D7ebwWPC7UmZ-ih-DvrBag" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" dim="Volume" quantityType="0" />
-                            <Parameter id="hPXfFMGboUW1p5o3yGc8Ow" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" dim="Volume" quantityType="0" />
-                            <Parameter id="6B6m6iDfKk2iT4KgHAWDhA" name="pH" description="pH" persistable="0" isFixedValue="0" formula="jHHiayqGOUKU0XSDd2BXPQ" dim="Dimensionless" quantityType="0" />
-                            <Container id="5blBCK5iJkiBq2lYLdl3Iw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Tags>
-                                <Tag value="MoleculeProperties" />
-                              </Tags>
-                              <Children>
-                                <Parameter id="S6xN3S9eF0mjR7F9b5H7Dw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_duo" dim="Dimensionless" quantityType="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="r2svWG0MLkW5Tj47fHn-hQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                          <Tags>
-                            <Tag value="MoleculeProperties" />
-                          </Tags>
-                        </Container>
-                      </Children>
-                    </Container>
-                    <Container id="bpNygYe-6EOR8ExXTayL3g" name="UpperJejunum" description="Upper Jejunum" icon="UpperJejunum" mode="Logical" containerType="Compartment">
-                      <Tags>
-                        <Tag value="UpperJejunum" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="6-tCGafkfUa6Qx2ftF6Vzw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="MucosaVolume.VOLUME_MucosaUpperJejunum" dim="Volume" quantityType="0" />
-                        <Parameter id="9z0Y4A77-0CsFq6JgxPGXQ" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_Q_lymph_mucosa" dim="Flow (volume)" quantityType="0" />
-                        <Parameter id="MI4m5c8OOU-l2qzYVFvH0A" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_J_iso_Mucosa" dim="Flow (volume)" quantityType="0" />
-                        <Parameter id="V0zLf6kHFEGIrirNZ-e-ww" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" formula="VascularEndoVolume.VOLUME_VascularEndo_uje" dim="Volume" quantityType="0" />
-                        <Parameter id="iv6DqX-cCkG1uCs9iYtNGw" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_Q_mucosa" dim="Flow (volume)" quantityType="0" />
-                        <Parameter id="1mgTk7-IAkyKPkVKUDyfIw" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_f_cell" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="J41yqOqfJkKisGxRVqvCiQ" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" formula="d43-0ymkzkyIG1NplDla8A" dim="Density" quantityType="0" />
-                        <Parameter id="5bguZ63bP0GT9BZAcfe7hw" name="Fraction of regional blood flow rate" description="Regional blood flow fraction supplying the mucosal tissue of the segment" persistable="0" isFixedValue="0" formula="y-bfU858WUKbQ3WFPA1raA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="TAwa__0VYkq8fVE1tIiaKg" name="Fraction mucosa" description="Mucosal fraction of regional intestinal tissue mass" persistable="0" isFixedValue="0" formula="oN2Rak2_EE6WY_0L1n2jzg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="sj_N1aMdLUGyaqPpOjmu5w" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" formula="gzkS6lYi1kabc6aDD-HwvQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="YHyq4U8UgkqY0b1lN_l0Jg" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" formula="8cNQTSv6zkyNfPKjmR6Yww" dim="Nanolength" quantityType="0" />
-                        <Parameter id="vnAHLLLdmU-r3sPZ7rEEuA" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" formula="qIVbnFMxk0moAvOAVjk-pw" dim="Nanolength" quantityType="0" />
-                        <Parameter id="okaUzYhkPEOLSXstw1tpjQ" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" formula="g-tjscKt30KOt076RTtCcA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="EE0BGBNUqkaVwxvGdufMOA" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" formula="VH5tVJKN8UepSzsAbs17Yg" dim="HydraulicConductivity" quantityType="0" />
-                        <Parameter id="Tzr6VE6Q60CGY-E0TKn33Q" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="hNtic53JS0Wo5LYfUzIidA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="FuLdGslTNEChKZ2Ty4lWlw" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="VdoH0j9L_0eZS9ZKjkLTiQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="y8pHC01Yv0mn6IgtDygoBQ" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" formula="DiHgya3600SV8EsUow-gZw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="99WyKaHgl0O33MFWbBi_vQ" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="dykXDuzuOUK7BglPHqzYcA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="zkvedwzM2kK0rdtq-9vSjw" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="x3Z3tDJ7i0yu33zRIv7LzA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="iav_qvdGgki4qeGo9tUNww" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="tux723VBCEKSL4ZL_z_0Uw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="OYxqYWuwAEGJT4_CMW71fQ" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="nnHBlci89EW_Z95m6ngC6w" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="svyPhoH_mkKFMcumRUS5PA" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="fRff7oTos0OU4pWQIOw9IA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="E4_juKn26kus_LJIIvXzhg" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="KTLI3DPEaEmbb_b8OI669g" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="MvhOFuEviU-MJsr39Ox_uA" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="ha9Co9dXc0au-9ajO5VxvA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="AAKoINi7GUqtSMLpZ7g15w" name="Microsomal protein mass/g tissue" description="Microsomal protein content per gram tissue" persistable="0" isFixedValue="0" formula="7Pc2hI60dkya7lPisVkFxw" dim="MassProteinPerTissue" quantityType="0" />
-                        <Parameter id="lEasbsxWnEqw5nCGDqqGmg" name="Number of cells/g tissue" description="Number of cells per gram tissue" persistable="0" isFixedValue="0" formula="HHtZVfNfBE-LeEfL-UtaSA" dim="CellQuantityPerTissue" quantityType="0" />
-                        <Parameter id="uaeci3e4-kmYFPLOPcM2cA" name="Protein mass/g tissue" description="Total protein content per gram tissue" persistable="0" isFixedValue="0" formula="YHHS-HnzAEeowJr14P8B-A" dim="MassProteinPerTissue" quantityType="0" />
-                        <Parameter id="kfTKf2ARIUC0IEtOofxWyQ" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" formula="mdkPUmAUe0KRNDjWcCZeIA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="02hWo01Ol0miNA9acbhtPA" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="P1TZglozskmq_WnNMVQPKw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="BD8MXLxIN0-_P08Nv3L-9Q" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="Fuq80ugtCU6dPt5GSgZb0g" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="swixLAx_TkGfg8eieTuKMw" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="pa3UHLbYBkuNK7H48idudQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="AgBI_M3m-EKBBfSQENkk9g" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="Z-dg56gXOUWqVGGxfbTcqA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="Zp_txsgvxk6ZJ6SX01i63g" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="sNkDYy9d1kqJdCGFeWr-hA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="1OzhLErNw0eb8Gn8hboJ4A" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="1BND9gXyX0OdDZAfL9Rj8w" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="Ahi5RniGa0KmFcEfwjK0ng" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="qdzrus3xPkm10Gef9oIJ1g" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="T2fAVV_wyUOnUWu1GiyWYg" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="WvDm_W3c_kS3_m_DkaLzVQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="rwINjo136kSaMIq7pdjE_g" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="LJsXZHeb0UCWtLsHu88UoA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="feuY2b4hIEOpkKrVdlj_DQ" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="NDqwrvC-WEyFdTXDR6owxQ" dim="Dimensionless" quantityType="0" />
-                        <Container id="Y5LCVOCIvUeBojIUHl8qUg" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Plasma" />
-                            <Tag value="Mucosa" />
-                            <Tag value="SmallIntestineSegment" />
-                            <Tag value="UpperJejunum" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="Xo2EYEIcU0mShlqszwakQw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                            <Parameter id="OJ2X1JRWEkCcjbN6blkH3Q" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" dim="Volume" quantityType="0" />
-                            <Container id="cws2QLx76k656HJOxV9CwA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Tags>
-                                <Tag value="MoleculeProperties" />
-                              </Tags>
-                              <Children>
-                                <Parameter id="Tkf0TDYylUu5sTXKE5DqNA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" dim="Dimensionless" quantityType="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="WRMyELazgU6an4teJnpZQg" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="BloodCells" />
-                            <Tag value="Mucosa" />
-                            <Tag value="SmallIntestineSegment" />
-                            <Tag value="UpperJejunum" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="oLWIrF29E0yVMFELZrRkxA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                            <Parameter id="RySUf3wXXUmvQhqQ9c5R0g" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" dim="Volume" quantityType="0" />
-                            <Container id="HoA6b3yfJkWjUOmvXxCEbw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Tags>
-                                <Tag value="MoleculeProperties" />
-                              </Tags>
-                              <Children>
-                                <Parameter id="m5N9SHrIMkWlI3w9zJfD_g" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" dim="Dimensionless" quantityType="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="ZTNzlNnynECErKkDEmJ9DA" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Interstitial" />
-                            <Tag value="Mucosa" />
-                            <Tag value="SmallIntestineSegment" />
-                            <Tag value="UpperJejunum" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="nCK3udVAMU6oi3637hVirQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                            <Parameter id="-1yAlmpfNkiDGHxbffpuIw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" dim="Volume" quantityType="0" />
-                            <Parameter id="915gOFr85UeV8zMtmH6Ytw" name="pH" description="pH" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_pH_INT" dim="Dimensionless" quantityType="0" />
-                            <Container id="zByb4GEyj0mTqr0fQX2nQg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Tags>
-                                <Tag value="MoleculeProperties" />
-                              </Tags>
-                              <Children>
-                                <Parameter id="wujJb_79NkmQTG28fg28Gw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_uje" dim="Dimensionless" quantityType="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="hh0X-zoJO0ioIifqKclJWw" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Intracellular" />
-                            <Tag value="IntestinalSecretionSource" />
-                            <Tag value="Mucosa" />
-                            <Tag value="SmallIntestineSegment" />
-                            <Tag value="UpperJejunum" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="DSnAmP8cO0attiQwilpjXA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" dim="Volume" quantityType="0" />
-                            <Parameter id="ii7r_qOIbESwbDw-CXINww" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" dim="Volume" quantityType="0" />
-                            <Parameter id="FExTSZVvLEyo4i8lB2pIgw" name="pH" description="pH" persistable="0" isFixedValue="0" formula="lkYjonfKO0qC62KI8qVr6Q" dim="Dimensionless" quantityType="0" />
-                            <Container id="L48aWUX4MESP5sxIE6DoIQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Tags>
-                                <Tag value="MoleculeProperties" />
-                              </Tags>
-                              <Children>
-                                <Parameter id="3d6FnHz1UEaNI3bPs1V9WA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_uje" dim="Dimensionless" quantityType="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="KkogQ6KFkUeolQZQsdslXA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                          <Tags>
-                            <Tag value="MoleculeProperties" />
-                          </Tags>
-                        </Container>
-                      </Children>
-                    </Container>
-                    <Container id="Y-DzqnuDOE2kZqEUQvWFqg" name="LowerJejunum" description="Lower Jejunum" icon="LowerJejunum" mode="Logical" containerType="Compartment">
-                      <Tags>
-                        <Tag value="LowerJejunum" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="LKa0NLiy5kWDZUVMO5QGig" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="MucosaVolume.VOLUME_MucosaLowerJejunum" dim="Volume" quantityType="0" />
-                        <Parameter id="05c3gajzGE2MT5Nc55jrfw" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" formula="VascularEndoVolume.VOLUME_VascularEndo_lje" dim="Volume" quantityType="0" />
-                        <Parameter id="WOtpnnMEVEWTQWKtYrVQpQ" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_J_iso_Mucosa" dim="Flow (volume)" quantityType="0" />
-                        <Parameter id="z2VpjFJ1rEa7C-XDMshGhQ" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_Q_lymph_mucosa" dim="Flow (volume)" quantityType="0" />
-                        <Parameter id="ObL3Yto38E6zOlA_Tey75A" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_Q_mucosa" dim="Flow (volume)" quantityType="0" />
-                        <Parameter id="XBDtWain_UmQugHgarx8rQ" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_f_cell" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="xaA-5pHzXUOJl3OpuPNTpA" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" formula="jFu4p8DA5k6s4mDODtASDw" dim="Density" quantityType="0" />
-                        <Parameter id="6G9OK1F4AUm7xvd1kbu8GQ" name="Fraction of regional blood flow rate" description="Regional blood flow fraction supplying the mucosal tissue of the segment" persistable="0" isFixedValue="0" formula="74KMhDu2Kky9xw7Zj4BiWw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="TV1vQI7UwEKGBgmF2XijdQ" name="Fraction mucosa" description="Mucosal fraction of regional intestinal tissue mass" persistable="0" isFixedValue="0" formula="ieUwiXE1IEa-UwAEAh4QOg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="eD9pQGRhTU23Oe8AREkwvQ" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" formula="Q3M8d8fDxECkoO0OaPUdkw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="uz1XKwZTdUuSYvufuqds_Q" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" formula="LE1J1NNtXEeC6tvyWAS3DQ" dim="Nanolength" quantityType="0" />
-                        <Parameter id="fpO1yhvcPke6jOiqnfsOxw" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" formula="sCN4SsvoVk2R_FKnKYwmcQ" dim="Nanolength" quantityType="0" />
-                        <Parameter id="DW_PBNUYF0ydtYUmlAjqvQ" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" formula="-nOcOyt4pk2YomEXUkEGpQ" dim="HydraulicConductivity" quantityType="0" />
-                        <Parameter id="CP98ii44hkieJBIU9cB06g" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" formula="B40-vaxxnUWhBr1hO4ZfHA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="Hfmj1_9kbEm4n33tsfPVIg" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="U3Jfl6KCGU-8ZHmR3WXgeg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="_T7-_o77K0-rqRkn3xL7_g" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="gkFOtDmnyESj5TiMMkysig" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="eicea43ElEuxX_wfQrxURg" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" formula="UXP6SoeK00SO4NG5eTM8pw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="8EqvK3AbgUuLhx4-IBlelw" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="0iNYNWxxLEO9rntQ9_dnyA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="QzOvwk9HW0er19pxWzcxXg" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="eQPK1zTQTkqv4zQMH3DkUA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="P2ZRPrtHzE28JSPE8V_4Cw" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="GvAo-3k_rEuoPacYhf-euA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="glODT_Z38k2pspkNHnBtBw" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="qmvsiEn7rUKn9dYoXc_qDQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="q2qJ5SNuekuH6JS9cbi9Cg" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="XM0jG4Zt3EOovWCjdU7Udg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="3OulxFpodUmhTLRIhoslsg" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="yY6vlY5V8kyoZLy6D8Sy3A" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="QU0xCVne-EW6v-gdvnufFA" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="AbwWY7i_M0Ww4QDXMh_M7Q" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="4J7NYY7vK0eBh6fxxf2hGA" name="Microsomal protein mass/g tissue" description="Microsomal protein content per gram tissue" persistable="0" isFixedValue="0" formula="_cVFNqNeAEOEcjcTusJ_rg" dim="MassProteinPerTissue" quantityType="0" />
-                        <Parameter id="qk-Vf1rLVU6lSlIt8MwmAQ" name="Number of cells/g tissue" description="Number of cells per gram tissue" persistable="0" isFixedValue="0" formula="xqpojo9luU66qCx4jyAzFw" dim="CellQuantityPerTissue" quantityType="0" />
-                        <Parameter id="OjRhFN3SSkyuU5VKffnfGA" name="Protein mass/g tissue" description="Total protein content per gram tissue" persistable="0" isFixedValue="0" formula="b6eXo3xPZ0KYYCBibhDIAA" dim="MassProteinPerTissue" quantityType="0" />
-                        <Parameter id="dEiBrc3UAESJYt6Tx5ji8Q" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" formula="-UB0l-9RZkCkbNYEU8Dpyw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="YKK7kL-2z0aMt7sW8xYbdA" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="KKRwILf83U2WU3EIYd18EQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="qy9WJI0hr0SV08rqHBXDLQ" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="snv75ZaJAk26JSPUGV1ZxA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="oVKnyqbClEq1bCDmH24cKA" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="nKyRRkPt2U2NzdeDWGXDYg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="f-M-8cBGp0-a3yWT9D1ZXw" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="uQ1RqjTbcUyD0k2Ut2libA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="--J4ekKExESr42APW9_5iA" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="dxwH2qj21US2DO6mTHHLvA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="PmAWSNogVECOi5Xq0VzvYQ" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="7bcg2-xqAUyarcX-DHvYNA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="nRzjw9fOfU-WyKRQdWFI5g" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="DD_WNDnVMkqrXEjgkKuO7A" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="N9KbyQPvB06sDLZ--SAI2g" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="G4ErznABKUy9jQg1OdDc1g" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="xYB0QeSbREuoTfem4Iu9yQ" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="wG8ZnIXmYkinIOftmjgGmA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="t5UrPAqkyESR2sEZILI94g" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="CXwb3L5DPE-MDyX-ZlV3_A" dim="Dimensionless" quantityType="0" />
-                        <Container id="OSgBdGflYku_NnIddypazA" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Plasma" />
-                            <Tag value="LowerJejunum" />
-                            <Tag value="Mucosa" />
-                            <Tag value="SmallIntestineSegment" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="XbXqayO-WUe2l5-mvO7GOg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                            <Parameter id="gLm6apA9B0-aV_J4cDd_5A" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" dim="Volume" quantityType="0" />
-                            <Container id="_aUlIOziSkq9P-sNhAA2OQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Tags>
-                                <Tag value="MoleculeProperties" />
-                              </Tags>
-                              <Children>
-                                <Parameter id="SO40JWngo0uNDqdk1G886Q" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" dim="Dimensionless" quantityType="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="md8QdYDu-E2ZDBw6wj8WEg" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="BloodCells" />
-                            <Tag value="LowerJejunum" />
-                            <Tag value="Mucosa" />
-                            <Tag value="SmallIntestineSegment" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="YKZyrdS5k0SWrj2M003_VA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                            <Parameter id="D3DlQUoJn0ml8CBRLcNFSQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" dim="Volume" quantityType="0" />
-                            <Container id="SMyXLXBVH0qKfDwsc6bJLw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Tags>
-                                <Tag value="MoleculeProperties" />
-                              </Tags>
-                              <Children>
-                                <Parameter id="7s8oaWQTHUiFuy7U2FqB3A" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" dim="Dimensionless" quantityType="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="mFJVbWQiyEeTSVQGayMAUQ" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Interstitial" />
-                            <Tag value="LowerJejunum" />
-                            <Tag value="Mucosa" />
-                            <Tag value="SmallIntestineSegment" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="PofogUeUo0SGYLS2zzQLYA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                            <Parameter id="9jLZ29VrzEShR0Hui063tQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" dim="Volume" quantityType="0" />
-                            <Parameter id="8Nt5znvEZUiZjJ59FkRUVQ" name="pH" description="pH" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_pH_INT" dim="Dimensionless" quantityType="0" />
-                            <Container id="hzgfFEEBc0qmqvq90jWoAg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Tags>
-                                <Tag value="MoleculeProperties" />
-                              </Tags>
-                              <Children>
-                                <Parameter id="Xdn-yZ_0CECe9mog7QfrcQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_lje" dim="Dimensionless" quantityType="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="e7tmWdt_iUatH8wBlrecHA" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Intracellular" />
-                            <Tag value="IntestinalSecretionSource" />
-                            <Tag value="LowerJejunum" />
-                            <Tag value="Mucosa" />
-                            <Tag value="SmallIntestineSegment" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="OoRe3TjSEUG8KPUpHgRPAg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" dim="Volume" quantityType="0" />
-                            <Parameter id="CvAgOHuY_EGQv4QizaePOA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" dim="Volume" quantityType="0" />
-                            <Parameter id="F7XOAmW5yES17y3qPbwxbg" name="pH" description="pH" persistable="0" isFixedValue="0" formula="jbUPvMuW5UGJQVq7jl_-Og" dim="Dimensionless" quantityType="0" />
-                            <Container id="yxjlVHn3qEWGru9vcBO2HA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Tags>
-                                <Tag value="MoleculeProperties" />
-                              </Tags>
-                              <Children>
-                                <Parameter id="25BTo4wgJ0WtgMVFda8oGw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_lje" dim="Dimensionless" quantityType="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="Sdlo6aZw20G9wwfKBTlLmw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                          <Tags>
-                            <Tag value="MoleculeProperties" />
-                          </Tags>
-                        </Container>
-                      </Children>
-                    </Container>
-                    <Container id="WWqGG6-7WEKyfCJeFrywiA" name="UpperIleum" description="Upper Ileum" icon="UpperIleum" mode="Logical" containerType="Compartment">
-                      <Tags>
-                        <Tag value="UpperIleum" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="4UHGS4ZGvEiERljWdybQaQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="MucosaVolume.VOLUME_MucosaUpperIleum" dim="Volume" quantityType="0" />
-                        <Parameter id="7MTqUm7oYUWQFmcGwbNAOA" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_J_iso_Mucosa" dim="Flow (volume)" quantityType="0" />
-                        <Parameter id="5jK1fBZfMUifAwrkYeNCzg" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" formula="VascularEndoVolume.VOLUME_VascularEndo_uil" dim="Volume" quantityType="0" />
-                        <Parameter id="pPgQqlOp6UuMR6dmbKwY1w" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_Q_lymph_mucosa" dim="Flow (volume)" quantityType="0" />
-                        <Parameter id="Efz7hVIRjkqhPjUeIFdCyA" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_Q_mucosa" dim="Flow (volume)" quantityType="0" />
-                        <Parameter id="65dK58NUHEWBOvRq_Vaghw" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_f_cell" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="VqJ5FEI-gUCCtVK3NFdIVw" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" formula="fGP8ZdvbVUCvO7FUuaRfZg" dim="Density" quantityType="0" />
-                        <Parameter id="RXDQxKApuE-k1oXcAV_PuQ" name="Fraction of regional blood flow rate" description="Regional blood flow fraction supplying the mucosal tissue of the segment" persistable="0" isFixedValue="0" formula="1OD1t_NL8Ea1F_kA5YV3Og" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="QUG05o2e70miAKukLn4Vaw" name="Fraction mucosa" description="Mucosal fraction of regional intestinal tissue mass" persistable="0" isFixedValue="0" formula="kWS6ubKLcEeHx2dZSHvKDw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="KLLcw9CTdEapyI43y44ymA" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" formula="wdMXJKubMEqOoV4EFTzAGg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="VEQSnCdsD06YCpJWVmDIeQ" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" formula="8mNulZZH8UKifR7q-Xo8zQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="sPGcOaeycUq0tyb1lkN0rw" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" formula="1GwninLPBU-g6vq5ecurvw" dim="HydraulicConductivity" quantityType="0" />
-                        <Parameter id="TkWH8k_2SEOnIkXYBzGsRw" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" formula="D6BJX2HlT0WnNnhhZz3ZBw" dim="Nanolength" quantityType="0" />
-                        <Parameter id="CCEiSymTDUelgV41DkePIw" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" formula="29nBLiNds0yLYsowrC1rIA" dim="Nanolength" quantityType="0" />
-                        <Parameter id="PGTuBfrCE0ui8MNuNK86xA" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="jhTDWxnNV0OGYBv8p73V7Q" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="mXfjHZwukkuzhRAnYotkew" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="TbRZYX09rUCAjpG5t94CEQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="wP9OJ9b78UqwodU8bCdKXg" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" formula="SGQaQmgS6EmJYFT4JBkbwQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="sp_DZBHYOUOVwLoefpFj0g" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="stCJwq0jbUiHKA1AjAQ6QQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="5HfYRyt49UajpBGrOLoOaQ" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="Q-rqs_7Kd0qyh1Dn7ZxBSw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="Zu3NxjqZEEi-ZUqEk7YKKg" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="6oP5qaGu-UuedYTw2Qm-UQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="IQxkaO6x9E6ySLumcQp-wQ" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="MBHp8JbYRUCv7P6LGGKSnQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="EIMgWornu02tBGjCVKqTCg" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="IymGCKIuFECpn3MLElHRbA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="mV2_8PgqRkSzdbvVT2FNpw" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="7F6Jeq2Kk06xgV6wgC8Y2Q" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="gtAvgu2YpkitF8qAS0kusg" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="PSW7ofKKeEyLuOG0FWbBZg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="ZxkC2s5cv0eFN-br8gk-wg" name="Number of cells/g tissue" description="Number of cells per gram tissue" persistable="0" isFixedValue="0" formula="vzFhWae_4U6nQBsBtErQXg" dim="CellQuantityPerTissue" quantityType="0" />
-                        <Parameter id="zz9Bs2wzlE-a9ZC5qxXUFw" name="Protein mass/g tissue" description="Total protein content per gram tissue" persistable="0" isFixedValue="0" formula="_AVm__YdZUu8gCU5whPBZw" dim="MassProteinPerTissue" quantityType="0" />
-                        <Parameter id="-U1Tv694xkClbuT78pf_vQ" name="Microsomal protein mass/g tissue" description="Microsomal protein content per gram tissue" persistable="0" isFixedValue="0" formula="2qRZlCf3l0uKn5NbbR117w" dim="MassProteinPerTissue" quantityType="0" />
-                        <Parameter id="V5j7xQNHQ0KcjQ0bzhHtew" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" formula="qYAj2GeWkU-eJLIyL5skdA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="BhFjdhBds0qhC0VOjgJ-TQ" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="LAZLsmwZOkCcgkjLkCRKBg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="n8VdFL_MXky9a2TEpi8C5g" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="93Je1GKG3UKL1jaNr1fHag" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="pupm_MSswEuTY5GTygsPYg" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="pJYfm5_dmku0cMQjqGKV2w" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="ai3iKJvZHkS5BM3i73VeKw" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="2rRygVT_hkCXEypgD6twNA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="CQ4q-wWHVEex-FYmYezr3Q" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="V9Jds5WJ_U653ltb4BDvmg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="L8DkLrZ4GkmsDHEWIVM2Zg" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="zjvMWaWETUmbLx0TWadYKg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="FPSA3_0zMEii0roeZn8BKQ" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="KYtHDDqk40WdRdCyf-PCSA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="XxkaQpnaikOSmw8HIOHK6g" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="g-W-kDijHUaa_NZiwZdLyw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="gcJDjiTAtkSwAgAEm531aw" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="mmIk1o06bkq0sGaBmKxhFw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="05gd0STIpUiOT4tkXxgs-w" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="po1WO3xvAEmLaI0G7CWgSA" dim="Dimensionless" quantityType="0" />
-                        <Container id="66G9xUKPyECPdQdGwnYfSw" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Plasma" />
-                            <Tag value="Mucosa" />
-                            <Tag value="SmallIntestineSegment" />
-                            <Tag value="UpperIleum" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="bu437-6nBkCje8CWyiUuLQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                            <Parameter id="CQ2DieiO0kmVVikYWK8w_g" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" dim="Volume" quantityType="0" />
-                            <Container id="_4ZBdq_HFUaUFsOlnDcZYw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Tags>
-                                <Tag value="MoleculeProperties" />
-                              </Tags>
-                              <Children>
-                                <Parameter id="ZDqB-Ei0Z0qHMZsULkUk9g" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" dim="Dimensionless" quantityType="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="VDYdAer0LkaTdqAFYYkuhg" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="BloodCells" />
-                            <Tag value="Mucosa" />
-                            <Tag value="SmallIntestineSegment" />
-                            <Tag value="UpperIleum" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="d1WwUwqon0-F5wi5CeUo3w" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                            <Parameter id="OMow5b5J5UCoUT0NTC_1pw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" dim="Volume" quantityType="0" />
-                            <Container id="yWgDlkiYO0yzdnlKXqMPOw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Tags>
-                                <Tag value="MoleculeProperties" />
-                              </Tags>
-                              <Children>
-                                <Parameter id="guOK1MTE50CKXOB9Z13MJg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" dim="Dimensionless" quantityType="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="Euo90j7RXEKG2jF2Qb1zJg" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Interstitial" />
-                            <Tag value="Mucosa" />
-                            <Tag value="SmallIntestineSegment" />
-                            <Tag value="UpperIleum" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="bJX0pBIEGkWxWRPCimBK4Q" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                            <Parameter id="odyf2DAy-ka4CkanlLssTw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" dim="Volume" quantityType="0" />
-                            <Parameter id="LgzDOeFiEk-B_Kp1EECXTg" name="pH" description="pH" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_pH_INT" dim="Dimensionless" quantityType="0" />
-                            <Container id="omNShsYDVkWVkn1oU9_3NQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Tags>
-                                <Tag value="MoleculeProperties" />
-                              </Tags>
-                              <Children>
-                                <Parameter id="Xte97wKjiUWY4lkYW_Cydg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_uil" dim="Dimensionless" quantityType="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="_XEu4SuUvUqKPjzK6x0c8w" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Intracellular" />
-                            <Tag value="IntestinalSecretionSource" />
-                            <Tag value="Mucosa" />
-                            <Tag value="SmallIntestineSegment" />
-                            <Tag value="UpperIleum" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="2r_6g1PM2kKboQ1k1hH17w" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" dim="Volume" quantityType="0" />
-                            <Parameter id="knm4lXPhd0eESHddramm3Q" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" dim="Volume" quantityType="0" />
-                            <Parameter id="W5TELvb4P0O0H_vHvnNoWA" name="pH" description="pH" persistable="0" isFixedValue="0" formula="K1P-JeymxkC1PQngy_A9LA" dim="Dimensionless" quantityType="0" />
-                            <Container id="UKbMnJCcZkehQVImZkpDsw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Tags>
-                                <Tag value="MoleculeProperties" />
-                              </Tags>
-                              <Children>
-                                <Parameter id="W3ZSiF9wFEWuFhHD1JPnew" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_uil" dim="Dimensionless" quantityType="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="Z1b3hbyuHkGyssm2E5B-6A" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                          <Tags>
-                            <Tag value="MoleculeProperties" />
-                          </Tags>
-                        </Container>
-                      </Children>
-                    </Container>
-                    <Container id="91udgVpZDEO6XiHqJ-A2FQ" name="LowerIleum" description="Lower Ileum" icon="LowerIleum" mode="Logical" containerType="Compartment">
-                      <Tags>
-                        <Tag value="LowerIleum" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="hRde3gzS6UyXn3xXuJ3LSw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="MucosaVolume.VOLUME_MucosaLowerIleum" dim="Volume" quantityType="0" />
-                        <Parameter id="JEoP-jS2_USUStbZ2BugVQ" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_J_iso_Mucosa" dim="Flow (volume)" quantityType="0" />
-                        <Parameter id="uKBxFogqEU2cqpHUTIJg9w" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_Q_lymph_mucosa" dim="Flow (volume)" quantityType="0" />
-                        <Parameter id="DQ9iyLceyEOldcdG6NIAug" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" formula="VascularEndoVolume.VOLUME_VascularEndo_lil" dim="Volume" quantityType="0" />
-                        <Parameter id="A0DNk9bUW0qWqhGek0rOMA" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_Q_mucosa" dim="Flow (volume)" quantityType="0" />
-                        <Parameter id="Wv_OD5Ctj0uuB6-0-y2MeQ" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_f_cell" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="RQYJyztRfEOAEzqkj1yoAg" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" formula="zVAguT96kkeqCuZaf_PSNA" dim="Density" quantityType="0" />
-                        <Parameter id="fk47x-JLDEmpSSU0x3qLsw" name="Fraction mucosa" description="Mucosal fraction of regional intestinal tissue mass" persistable="0" isFixedValue="0" formula="auI0701hWUmFKoegan70nw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="ZdITiahW8k6wg6yy5OPsKw" name="Fraction of regional blood flow rate" description="Regional blood flow fraction supplying the mucosal tissue of the segment" persistable="0" isFixedValue="0" formula="oa5qKCuIiEmX7tHtDoC5Wg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="aSBpRo0pWE-QGul7F3QF8Q" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" formula="rB_Yk2w4e0qYZurKatLqfw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="FGY4FaVHSEesH_cVerLSEw" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" formula="MoLfwXZuxka2ajjdNHEMgQ" dim="Nanolength" quantityType="0" />
-                        <Parameter id="OxwQODZ6IkqmDeCFlU_3NA" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" formula="gOjcVYTrZkOYWmExUGdJ0g" dim="Nanolength" quantityType="0" />
-                        <Parameter id="KiDvg02r3UqESBIDwNeJ9Q" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" formula="2VGK2opmj0myehTl34CNrA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="EO3o7_M8L0SMPEjy_lM0-Q" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" formula="Yqse_bK0qUGqPDEJMbVfKQ" dim="HydraulicConductivity" quantityType="0" />
-                        <Parameter id="poPGExA9zkmrHitb4A0jVQ" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="5S7OW5wdxUyQFpFQ9shayQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="K9zS1X0_U0O1QiV01fxarw" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="IU5WOVtN9UCUcFOawHxTlQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="rxxmTd3LC0-YLdoU0e0gKg" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" formula="ldMVmievik2tx4-Jk1kdMg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="X7mPjho2KkqVMTOjjaWEeA" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="rbGei5ARTUq-FrLrmtj9cw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="vuIJwTXEvkWiptyWIwFNhA" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="ZuRg4BHFO06g-Yayxqo6AQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="nQ2jpQEDykipc6HDXI_Jyg" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="R6O-9twheU6EhJ2BaRagMg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="GV3fs55PdEuf6Xn1SEq_xQ" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="s2F_F5k0EEihKRabQfALPg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="BM_Sorq2MUqy-jNVCRA-0A" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="fWJeXly9rE-hmPn2M9eMPw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="IN8ACt6HjUW6HJjCPjqW7w" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="Kem8NcPZUU2NyQ7voS_nbQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="Xyos6F_5pU2hGQhazCLxbQ" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="dscwQwSmOEOwtQWstXssbg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="p4ju2Y9HFEmCoRl4mA0P5A" name="Protein mass/g tissue" description="Total protein content per gram tissue" persistable="0" isFixedValue="0" formula="qQGTrIZH8kqYlJi1OGJOgw" dim="MassProteinPerTissue" quantityType="0" />
-                        <Parameter id="EHj91gV_IkGCscu_ue-GpA" name="Microsomal protein mass/g tissue" description="Microsomal protein content per gram tissue" persistable="0" isFixedValue="0" formula="hL0M52S1Rky967fnfsklMA" dim="MassProteinPerTissue" quantityType="0" />
-                        <Parameter id="7lrWA_19tk2CZCuoqxEOcg" name="Number of cells/g tissue" description="Number of cells per gram tissue" persistable="0" isFixedValue="0" formula="S4sKKbMgUk6NjzFVi5si-g" dim="CellQuantityPerTissue" quantityType="0" />
-                        <Parameter id="jlrk_3qTpk23m0Dp83Sybg" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" formula="RAGFxChcyk2hapfqYd327w" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="H8zX7vY_8Eevn_u_-aCwkQ" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="1IYz-U9E90SH-lsYm2A76Q" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="uxfqzDdvhEmR0Wxr0skC9w" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="0KhN6V9LpUW3AUX_9clhIA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="0bnypDdHJkqQYnH-l6tQXQ" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="U78SUij4dkC-QiNhO2wiug" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="8QBTXdwvAEOgcYtkzGKnIg" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="t4Lmz0K7EECJMqpy-4AReQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="LhpRnTfwwkiWlb14FXgnRA" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="lBLtyKaeX06cP02ZxQpdBw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="qupXsZTtlkC7cCX1aWDoYA" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="i4f-bkqtc0S4px1kMcNGDQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="iLmuT0uSe0iwseA2cDSaeg" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="2Sdet-XzPUO9jRzN785Adg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="eJrplflhxUqYsYDzl8je4g" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="AmkRTU-340SE3ITQKvo_mQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="Ny0_xkE3fkayKF8KhGWfgQ" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="XbpZ-w0c5kGEq_E8SKzKMQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="QIPCecP82UaPvEhs3bVUsg" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="qQ1oMitjJkufYcSkhlx3fg" dim="Dimensionless" quantityType="0" />
-                        <Container id="HOj-zR3PPUW6yX-B0rLz0g" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Plasma" />
-                            <Tag value="LowerIleum" />
-                            <Tag value="Mucosa" />
-                            <Tag value="SmallIntestineSegment" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="tGt2tv0nqUWPl7AE41B3Qw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                            <Parameter id="e5AZil9u4UyYhtGnUZN_Hw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" dim="Volume" quantityType="0" />
-                            <Container id="oCJn-JgGxkSp6piZhbxmVA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Tags>
-                                <Tag value="MoleculeProperties" />
-                              </Tags>
-                              <Children>
-                                <Parameter id="VhhSNxzcd0SYsVjrD-Aw1Q" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" dim="Dimensionless" quantityType="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="MFDAv_PfOkiQzDjjkslSHw" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="BloodCells" />
-                            <Tag value="LowerIleum" />
-                            <Tag value="Mucosa" />
-                            <Tag value="SmallIntestineSegment" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="mLd1SEfDPE2wFJ1retLkGA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                            <Parameter id="5bzcohkXoUaIzw0h-GFwbg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" dim="Volume" quantityType="0" />
-                            <Container id="SKDkfVoZ20OzMyryGsZcwQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Tags>
-                                <Tag value="MoleculeProperties" />
-                              </Tags>
-                              <Children>
-                                <Parameter id="GoAJX4tUp0CeWjimasSebQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" dim="Dimensionless" quantityType="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="J3IEuqYFyUSB5ap7fJ9EXQ" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Interstitial" />
-                            <Tag value="LowerIleum" />
-                            <Tag value="Mucosa" />
-                            <Tag value="SmallIntestineSegment" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="G-1yH-elsUqFjUAWSYjC2w" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                            <Parameter id="qHrbH50AmUOnCQFkXV9nWw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" dim="Volume" quantityType="0" />
-                            <Parameter id="efvnERAn2U2CpPhLmGSkFw" name="pH" description="pH" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_pH_INT" dim="Dimensionless" quantityType="0" />
-                            <Container id="N7wlsj6sUkOOuRRkGM244w" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Tags>
-                                <Tag value="MoleculeProperties" />
-                              </Tags>
-                              <Children>
-                                <Parameter id="eb8CmLB4p0yNS_crQ24EtA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_lil" dim="Dimensionless" quantityType="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="O2GTTPwRekuvYZ3QMo8Raw" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Intracellular" />
-                            <Tag value="IntestinalSecretionSource" />
-                            <Tag value="LowerIleum" />
-                            <Tag value="Mucosa" />
-                            <Tag value="SmallIntestineSegment" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="I9vfpW85kE-DeO-wu27esA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" dim="Volume" quantityType="0" />
-                            <Parameter id="FyPRFOElUESgYNHnI-Rsyg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" dim="Volume" quantityType="0" />
-                            <Parameter id="B_K3TlEgykaynp5svZ8j3w" name="pH" description="pH" persistable="0" isFixedValue="0" formula="G--AxaIfo0y9teWydo6ltw" dim="Dimensionless" quantityType="0" />
-                            <Container id="aUuaOGI8UEedncecfQf9_w" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Tags>
-                                <Tag value="MoleculeProperties" />
-                              </Tags>
-                              <Children>
-                                <Parameter id="l_jsYoGWWEq0MsQHq1sRsA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_lil" dim="Dimensionless" quantityType="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="NPeQKp7lOUiXG5YEkPRjaw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                          <Tags>
-                            <Tag value="MoleculeProperties" />
-                          </Tags>
-                        </Container>
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-              </Children>
-            </Container>
-            <Container id="9MF_4L9PYkyzjJaifeV48A" name="LargeIntestine" description="LargeIntestine" icon="LargeIntestine" mode="Logical" containerType="Organ">
-              <Tags>
-                <Tag value="LargeIntestine" />
-                <Tag value="Portal Vein Supplying Organ" />
-                <Tag value="TissueOrgan" />
-              </Tags>
-              <Children>
-                <Parameter id="cu2SPOKhfUmGOn--gzLQrg" name="Large intestinal transit time factor" description="Large intestinal transit time factor" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_LITT_Factor" dim="Dimensionless" quantityType="0" />
-                <Parameter id="n4UMYuPUUkms_m9tu9Gtpw" name="Volume (mucosa)" description="Volume of mucosa" persistable="0" isFixedValue="0" formula="MucosaVolume.VOLUME_LargeIntestineMucosa" dim="Volume" quantityType="0" />
-                <Parameter id="7bBh-9qNHkSBNLSECUGlYg" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" formula="VascularEndoVolume.VOLUME_VascularEndo_lin" dim="Volume" quantityType="0" />
-                <Parameter id="Qgb_hOq0aU6IFloNp5eVcg" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_Q_Lymph_lin" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="FtYFm5LYGEOA0S3MBqiWEg" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_FluidRecirculationRate_lin" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="EW2Hh6-FlU2wYCU8pePx4A" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_f_cell" dim="Dimensionless" quantityType="0" />
-                <Parameter id="Ax4CopGVJU-XvRpYq-wAVw" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_Q_from_Qspec" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="hfT6AgWgH0qpnWwrxZlKrQ" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" persistable="0" isFixedValue="0" formula="ybFwFsSPdk-tWF9v_RvErw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="XTNMzE1ILU-CwJxnGNiS7g" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" formula="WF7KodxRI0WmJzrZIZIJsA" dim="Density" quantityType="0" />
-                <Parameter id="vE4n8OUtzEWMfvVMg3yGqQ" name="Excretion_Time_k2" description="Supporting parameter for calculation of excretion time" persistable="0" isFixedValue="0" formula="31yVQQT_K02UVqX40b5KvQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="pzye8VISakup3uGfh_1R7A" name="Excretion_Time_k1" description="Supporting parameter for calculation of excretion time" persistable="0" isFixedValue="0" formula="rHdo-Unqh0KfS74iZ2kpig" dim="Time" quantityType="0" />
-                <Parameter id="l0YfQ2oNAkG9fHWDNUNTew" name="Excretion_Time_k0" description="Supporting parameter for calculation of excretion time" persistable="0" isFixedValue="0" formula="NIwZbzY_Yku8Zo7lZMyilQ" dim="Time" quantityType="0" />
-                <Parameter id="UCTYGhGKDkKH1LV6kWOqcQ" name="Excretion time" description="Excretion time" persistable="0" isFixedValue="0" formula="Q3GmIsOBL0G6asO1W6EHxQ" dim="Time" quantityType="0" />
-                <Parameter id="Gqye7f1UXk-d3x_mlBINEA" name="Mucosa blood flow fraction" description="Blood fraction which goes to mucosa" persistable="0" isFixedValue="0" formula="kEUz5mL13kWxXvZqrw9NzA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="B13p0y3I4kCo0MKUnSbeqg" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" formula="4oa5tPRxpUa4u422abnQ8w" dim="Dimensionless" quantityType="0" />
-                <Parameter id="-V31yGQ4-0S7kwnCIuD6mg" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" formula="NlrTN83iBki6KDDMAsOATg" dim="Nanolength" quantityType="0" />
-                <Parameter id="NzwRf2YHKkeoXd82QzBxtQ" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" formula="4WtUYzh-G0CH1-TthyW44w" dim="Nanolength" quantityType="0" />
-                <Parameter id="1GiZkaznGkuuKUbHqHEyYg" name="Lymph flow rate (incl. mucosa)" description="Lymph flow rate (incl. mucosa)" persistable="0" isFixedValue="0" formula="7j9CsT_2uku8zJUwX_NHbg" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="KQqVF8xTH0CW9tkYqhKirQ" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" formula="u4xi5TLne0qSHxcjSg78vg" dim="HydraulicConductivity" quantityType="0" />
-                <Parameter id="kpaLcVnY20e78zIkHYSSlA" name="Fluid recirculation flow rate (incl. mucosa)" description="Fluid recirculation flow rate between plasma and interstitial space (incl. mucosa)" persistable="0" isFixedValue="0" formula="yBoCJCmy8UuK0QdvAMYttg" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="EldxZbEuXkqyjMWlFtsqNw" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" formula="fcPd3k8QxEGjWrloAr4RMg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="k-9A-VkQDUqIMjGU41Js9A" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="l02L8XH5CUWksj94wRUpuA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="wuMQ28rGoEuuCnJ9K0MFnw" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="8jW-pyDTZEqIZb_ucYUEYA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="SzbPJJaDVkebtGgYX1T2VA" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" formula="tt6buBBcv0WqjEq1j-xGng" dim="Dimensionless" quantityType="0" />
-                <Parameter id="gPVvQBiv-UWcMTU91VwByQ" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="cl3vSHmEi0GUyvdjacY6QA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="kTMVgzqEbkqiugON2PyOQQ" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="6_w3INwnN0qRjHFBCKW2fQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="NXwCTg6d3UeCS_HgYJqb2Q" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="5GeLi04y60eU-JYdGunkHw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="JntacpxcYEKxMw-d3vw48Q" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="gFv0Y1bZNEG8cTLlYxrPqg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="-JGr2eI9yEa3q2nQTKlJPQ" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="M2OTBju8DUClfxYEr0M1vw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="Mt98IJ4MbU6iAYEhuScvVg" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="WJWWF0x8ukqQOebXn7AUhg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="09dydKAcm0euX80YzGmfRw" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="noSZ-yswjEOvGPrR_KaL0Q" dim="Dimensionless" quantityType="0" />
-                <Parameter id="97K5QZmrdEuXodsp9UrRBA" name="Protein mass/g tissue" description="Total protein content per gram tissue" persistable="0" isFixedValue="0" formula="LsNixsd4YEq_ixFANfs6cQ" dim="MassProteinPerTissue" quantityType="0" />
-                <Parameter id="lEurKwThC0GRr2hR-bOBsg" name="Microsomal protein mass/g tissue" description="Microsomal protein content per gram tissue" persistable="0" isFixedValue="0" formula="TRkKtRL0P0CmUEvlaD3zrw" dim="MassProteinPerTissue" quantityType="0" />
-                <Parameter id="Gn7sVXO23kyupB3l-qPa0g" name="Number of cells/g tissue" description="Number of cells per gram tissue" persistable="0" isFixedValue="0" formula="RHNmRB3QiUiUmOftoYxwMw" dim="CellQuantityPerTissue" quantityType="0" />
-                <Parameter id="ONH0mSVg2UG9kBsH5J35iQ" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" formula="rH2Hb-2WYEuB_lprUmD0cw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="CyRzAmut20GGrPtg7peJMw" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="LcCarURvN0-gaeJZIQq9OA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="T_UX2Fp2lkGH4aKSfnceIg" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="ZGIQfDMM2E28tDogVwi09w" dim="Dimensionless" quantityType="0" />
-                <Parameter id="DiBen34elUCTj9fG6fWatg" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="Ff9MaSSPN0OWh0G1Lhvi5g" dim="Dimensionless" quantityType="0" />
-                <Parameter id="kjlglYVwJ06CaWqJAABBfA" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="3izNV4uU30aslN44O-TuUQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="UF9I8YFrHE-038GrFz8gdQ" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="BeN1OC6D0EG91IRRRnOUMg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="l-cboEdoAEeheRD6knUBmQ" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="hgtokakl4kaOVYce7ly4vw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="JGNraUaWMkKKjArlIUaf7A" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="pHVzUppedEeRx32HxFAycQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="w9ACFYgZQkS-chGw8V8NMg" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="479NN_2WyUGeFcurbj1L5w" dim="Dimensionless" quantityType="0" />
-                <Parameter id="3rLwNvuuz0W5YkaVOIqQJQ" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="yK33KhIE7kGFu8-yWBwVbg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="f-jiNQteZEuhMTZAXvlqXw" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="_gE4f5w5tkafMxwo201EGQ" dim="Dimensionless" quantityType="0" />
-                <DistributedParameter id="K6KodFMsQUGsFmdaLrNlrA" name="Volume" description="Volume of organ or compartment" persistable="1" isFixedValue="0" formula="s4-Kcq3jTE-d6vV51TmPsw" dim="Volume" quantityType="0" mode="Logical">
-                  <Children>
-                    <Parameter id="CvSSessmc02NwH7wJWZ60g" name="Percentile" persistable="0" isFixedValue="0" formula="OKWTBeTMQkibTCVi83wKEA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="WOSjDDA_cECwVdxXLOZCiQ" name="Mean" persistable="0" isFixedValue="0" formula="_naCA5KUCE6RCvbRlmsnVA" dim="Volume" quantityType="0" />
-                    <Parameter id="IQCBs9uYmE2YAL7voxgnsQ" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" formula="lLs-f_W_0kKoVLII8CjpyQ" dim="Volume" quantityType="0" />
-                  </Children>
-                </DistributedParameter>
-                <DistributedParameter id="-y7c6AE3cU-QiY30dZHO0A" name="Specific blood flow rate" description="Blood flow rate normalized to the organ volume" persistable="1" isFixedValue="0" formula="mnuHl4gPfEyw86aS_ajSMw" dim="Flow (volume) per organ weight" quantityType="0" mode="Logical">
-                  <Children>
-                    <Parameter id="5KdfizxAzkSvGNgZLzLSug" name="Percentile" persistable="0" isFixedValue="0" formula="KMvkmFn5bE6zIe3JOQ3fGg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="pgooNYkYzUmgurGHa59emQ" name="Mean" persistable="0" isFixedValue="0" formula="nwJes-e9C0-M_N4GTkZMew" dim="Flow (volume) per organ weight" quantityType="0" />
-                    <Parameter id="rwFPtiHFVEOQO1uTUwfXyg" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" formula="H-MCzcD4YkqMBesTS7xzJw" dim="Flow (volume) per organ weight" quantityType="0" />
-                  </Children>
-                </DistributedParameter>
-                <Container id="KnL-t0swKEGlt4XXJPF8sA" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Plasma" />
-                    <Tag value="LargeIntestine" />
-                    <Tag value="Portal Vein Supplying Organ" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="hEKeaAaM50e_zg_gUnnuAA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                    <Parameter id="i-eTtq40NkS00rQloVNdCA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_pls_SinLin" dim="Volume" quantityType="0" />
-                    <Container id="bWqTEvjt806BnLf-OQwJig" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Tags>
-                        <Tag value="MoleculeProperties" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="qKhuP4iPKESgzO_-y0B4cw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" dim="Dimensionless" quantityType="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="4VlXh1FvuEi4iThCgPo84g" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="BloodCells" />
-                    <Tag value="LargeIntestine" />
-                    <Tag value="Portal Vein Supplying Organ" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="9g75SWgqHkWumoOYZje07w" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                    <Parameter id="wgTCHLpbBEiQk7Aftz12zA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_bc_SinLin" dim="Volume" quantityType="0" />
-                    <Container id="6kr6y7MHYUqOQTOXN2ZU1A" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Tags>
-                        <Tag value="MoleculeProperties" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="YWg2hmGi-EWL7HDyFSelzA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" dim="Dimensionless" quantityType="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="aKhkW1Ped0KharW9yTH8kQ" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Interstitial" />
-                    <Tag value="LargeIntestine" />
-                    <Tag value="Portal Vein Supplying Organ" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="vPzuuvliZ0itQ_fzaBhxxA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                    <Parameter id="zosEMWz9IE-EKH2IqoOkUA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_int_SinLin" dim="Volume" quantityType="0" />
-                    <Parameter id="s07hpIi-YkicmNU3W8npmg" name="pH" description="pH" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_pH_INT" dim="Dimensionless" quantityType="0" />
-                    <Container id="--AU14GzhU-gdGh7WhfzOg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Tags>
-                        <Tag value="MoleculeProperties" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="l4AaW3DoWEi58XjZT98dcg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_lin" dim="Dimensionless" quantityType="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="kUScFceMJk2wTz5XwgEvTQ" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Intracellular" />
-                    <Tag value="LargeIntestine" />
-                    <Tag value="Portal Vein Supplying Organ" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="QUd0vJ8M7ECq-s0BtBdoGQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ_SinLin" dim="Volume" quantityType="0" />
-                    <Parameter id="GXGDGMl-1kCVjKYRPkHGiw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_cell_SinLin" dim="Volume" quantityType="0" />
-                    <Parameter id="Ti0jBLrIYkqV3f7lH89_qw" name="pH" description="pH" persistable="0" isFixedValue="0" formula="91H8LLUO4U22eA_wTHC7ug" dim="Dimensionless" quantityType="0" />
-                    <Container id="jGR2p-h9rEqbphsolUi1gA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Tags>
-                        <Tag value="MoleculeProperties" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="jvCoLPAT8EqqYAGXuNTI3A" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_lin" dim="Dimensionless" quantityType="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="dkeKrzn1rUCIldYdXcHIXA" name="Mucosa" description="Mucosa" mode="Logical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Mucosa" />
-                  </Tags>
-                  <Children>
-                    <Container id="RKM2WKz6Lk2rb_4mY-Nqxw" name="Caecum" description="Cecum" icon="Caecum" mode="Logical" containerType="Compartment">
-                      <Tags>
-                        <Tag value="Caecum" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="yE3wQJrOt0O1pPYtSRqekg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="MucosaVolume.VOLUME_MucosaCaecum" dim="Volume" quantityType="0" />
-                        <Parameter id="q-HaC1yO9EyhNlv2ctLPrw" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_J_iso_Mucosa" dim="Flow (volume)" quantityType="0" />
-                        <Parameter id="rN8qw1AS6EqpidBDV-0s1Q" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_Q_lymph_mucosa" dim="Flow (volume)" quantityType="0" />
-                        <Parameter id="F-gZWZoPSke0kS6wzZmF_w" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" formula="VascularEndoVolume.VOLUME_VascularEndo_cae" dim="Volume" quantityType="0" />
-                        <Parameter id="P5Ha9BpRnUiiFcUHPi6pKw" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_Q_mucosa" dim="Flow (volume)" quantityType="0" />
-                        <Parameter id="01DjfelkkkKx0B88nZahEA" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_f_cell" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="85wX2T0Lvkmj5h6OFqupNA" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" formula="Egi5OY-NA0iGdsGr68ubpw" dim="Density" quantityType="0" />
-                        <Parameter id="AskS6BYAXUGbVOfeFfHcsw" name="Fraction of regional blood flow rate" description="Regional blood flow fraction supplying the mucosal tissue of the segment" persistable="0" isFixedValue="0" formula="ZcfE9L6d20-ZK2hT0d3N5Q" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="HdR3e3SePU6L0ZNq5Gh84w" name="Fraction mucosa" description="Mucosal fraction of regional intestinal tissue mass" persistable="0" isFixedValue="0" formula="K3MwZsGzB0-PK5fplFfXag" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="ix0CkvRw30ij4KuoVRe59g" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" formula="aeo3WJyJkkyJyRkTcXwEvQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="tIjtIzkw2EWKCg4gLYULVQ" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" formula="OpneXWx_skSkFBxSmctF6A" dim="Nanolength" quantityType="0" />
-                        <Parameter id="5mm1D1sfG0OqZvJ5c_-6Ow" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" formula="8RrJhJNBtUeI26WH12ELRw" dim="Nanolength" quantityType="0" />
-                        <Parameter id="wyaTDEAQn0u8TaFJ8u5roQ" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" formula="cYH0gHJ0ZU-CrFJD4-A9MQ" dim="HydraulicConductivity" quantityType="0" />
-                        <Parameter id="T9yTznGBJ06OHJ2dWZfNdg" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" formula="RTU7tbeEoEOMLZokPVIQjw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="Unvk2g3tEUqKeUuM74cP7g" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="TJ48iKPtmEqMJm1Byy4mqQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="R48h_NK3aUqZYfWx096b8Q" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="BpNqYuVDU0GWEx2wXNtjxw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="Yf4Q2m1g7k2WZdmAoku4RA" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" formula="KVaRz_0xY0qEi1O6SaBpBw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="F7qTsrU5IkK3kK0C87oooQ" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="jPOde9iJS0ymm7MugOorCw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="FghiRsb4MU-B9C8ZzjoshQ" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="i7pmVHm9fEylZ4ahSq9iKg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="MyvK-WFy90qfFOQLhKZOtg" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="qqfGFiAvZUq-7lbp8VR2Lw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="uXpPTLDrS0m0nGFhR5Umcw" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="NRmIqw3QpU-In3Wpi_tPuw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="Eq_wHEvcqkmhVaYUMfGI-Q" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="ijH0bufl7Em7qwfoWkxVAA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="0E56ou9YMUy31lA-ypGB-g" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="INrTybwzcUi85ZCx55gmGA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="kcEp0oM-HkmF06LXogZXrg" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="4lFxB9R20Ue3SUDlzxGIqQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="PZ4R-ynnIEaIv649hIgC_A" name="Microsomal protein mass/g tissue" description="Microsomal protein content per gram tissue" persistable="0" isFixedValue="0" formula="pR9lYWtOKkedIOZPsb0N6A" dim="MassProteinPerTissue" quantityType="0" />
-                        <Parameter id="vQcruRh5Wka1tYi54UcZcg" name="Number of cells/g tissue" description="Number of cells per gram tissue" persistable="0" isFixedValue="0" formula="whA_DV3pL0eZbnFZ7YJbzg" dim="CellQuantityPerTissue" quantityType="0" />
-                        <Parameter id="IAKibZNXr0-Ok4vL5MJE8Q" name="Protein mass/g tissue" description="Total protein content per gram tissue" persistable="0" isFixedValue="0" formula="-vfVJ-1PUk2tWArn0KsUwA" dim="MassProteinPerTissue" quantityType="0" />
-                        <Parameter id="t-SWCocjfkSFNIZJ1WpMmA" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" formula="mmWTIvYBfUqEv6XnsXCq1w" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="Hegdj5bc7Uq-bWga5bB5Yw" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="SP1VmDP5Sk6b6_7_9RxKrA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="-wknK6E-ZEiJFRZ5AtkIng" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="p-3-F80iskqNj7cDh4lTNA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="qps9VmpShkiVnIPCh267Pg" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="MKB1T56Wf0-m-t6ZYCB-uQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="cyM0EKNNHkCoO0R6cXexwA" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="x0PiX6MBGUyMOiy43IEuBw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="3GV8qNWUZ0aqruS0l-gWQg" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="IMt5D4W-5UGHdpQiS5OO2g" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="w6ZYjDMn7kahU1ulqkOQBg" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="hJkt-lmAj0iQGctdhuhVmw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="tHyT55uMuEC1Rg4A8tOg8w" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="CBNd33N9lkqrjVwdhPQI-g" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="ueC6GVhLGkKxb4wNrHTHYg" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="QC4DShzS_kC-jH26-yg4bg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="vA9WljwH3UimG6FyANJhqw" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="3oUp0B3l6U-TBj2wHdQB9g" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="_B89TGvz7k6Mv04_A06tTQ" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="sSKVoE_KfE-aFe3izCINdg" dim="Dimensionless" quantityType="0" />
-                        <Container id="CKUV4Ze6d0eoYQnRGiicug" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Plasma" />
-                            <Tag value="Caecum" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="9yQYtVy1dUeHVb-bw_gxzQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                            <Parameter id="OcIXzYSLD0e1B5tV7uJX1Q" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" dim="Volume" quantityType="0" />
-                            <Container id="AbaDr3UUTUuydRGif6yk-g" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Tags>
-                                <Tag value="MoleculeProperties" />
-                              </Tags>
-                              <Children>
-                                <Parameter id="iGtvSB-DSUiHCE8lYYizfg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" dim="Dimensionless" quantityType="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="b6vJ67uVlUGBdmnT37TEDw" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="BloodCells" />
-                            <Tag value="Caecum" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="tq54eYR9SEWdh72f-ZhX9A" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                            <Parameter id="HZ_3BDKekEmuapf3Ohe08w" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" dim="Volume" quantityType="0" />
-                            <Container id="QJksc174q0SHD3Zb8-lq5A" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Tags>
-                                <Tag value="MoleculeProperties" />
-                              </Tags>
-                              <Children>
-                                <Parameter id="xs9ifODT0EqsGXOmr0zYpg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" dim="Dimensionless" quantityType="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="DO-uiyvH6kydG7Dl1iSS2Q" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Interstitial" />
-                            <Tag value="Caecum" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="JBdZZIZCE0Cnd0lsIO-7gg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                            <Parameter id="94vNLJEPaUGvLdbjnsfn5w" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" dim="Volume" quantityType="0" />
-                            <Parameter id="KqwHI7r0Ike1Xsjftu9FtQ" name="pH" description="pH" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_pH_INT" dim="Dimensionless" quantityType="0" />
-                            <Container id="_5VIX3-XU0uv1tKOSsAloQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Tags>
-                                <Tag value="MoleculeProperties" />
-                              </Tags>
-                              <Children>
-                                <Parameter id="HT4QsAja8kqcKpAmjvgE-w" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_cae" dim="Dimensionless" quantityType="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="H5cljX5ikE-xPBwWkmCcVw" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Intracellular" />
-                            <Tag value="Caecum" />
-                            <Tag value="IntestinalSecretionSource" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="hHv5h8R7HU6tupQQfqHNwA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" dim="Volume" quantityType="0" />
-                            <Parameter id="qVVFZsF3D0KNUED2PN_7iw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" dim="Volume" quantityType="0" />
-                            <Parameter id="qfL-E9Gy_0OtfzOwkedEhA" name="pH" description="pH" persistable="0" isFixedValue="0" formula="vJj08grGTUuNJZDNmzLDSQ" dim="Dimensionless" quantityType="0" />
-                            <Container id="Ca5ei0pzrESjHTlqmrI-OA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Tags>
-                                <Tag value="MoleculeProperties" />
-                              </Tags>
-                              <Children>
-                                <Parameter id="kzD3qdpuCEC75-ENCTR7EQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_cae" dim="Dimensionless" quantityType="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="8O4KSU3feUKZt_niy_ZXZA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                          <Tags>
-                            <Tag value="MoleculeProperties" />
-                          </Tags>
-                        </Container>
-                      </Children>
-                    </Container>
-                    <Container id="uyXF9muTF0W_YGdIeMSKvQ" name="ColonAscendens" description="Colon Ascendens" icon="ColonAscendens" mode="Logical" containerType="Compartment">
-                      <Tags>
-                        <Tag value="ColonAscendens" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="R3k2ShBkdESC9NAi7pmYdA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="MucosaVolume.VOLUME_MucosaColonAscendens" dim="Volume" quantityType="0" />
-                        <Parameter id="qY3t7RwzeUWeatJcwijEog" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" formula="VascularEndoVolume.VOLUME_VascularEndo_colasc" dim="Volume" quantityType="0" />
-                        <Parameter id="MXnCli7JG0a3WLXE-1sK0Q" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_Q_lymph_mucosa" dim="Flow (volume)" quantityType="0" />
-                        <Parameter id="y_ISXWO5x02XWF2GO3rxCA" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_J_iso_Mucosa" dim="Flow (volume)" quantityType="0" />
-                        <Parameter id="I5qjZrIVREqjdHtB6SgG-Q" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_Q_mucosa" dim="Flow (volume)" quantityType="0" />
-                        <Parameter id="7yn27u1v0kyh18GnNL-nEw" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_f_cell" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="NKfJmdbq2k-sxnGC_3uhHQ" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" formula="Ul_IRNnrfU-R68P_myQrMA" dim="Density" quantityType="0" />
-                        <Parameter id="DRPGDpkkI06OB8IbzUAroQ" name="Fraction of regional blood flow rate" description="Regional blood flow fraction supplying the mucosal tissue of the segment" persistable="0" isFixedValue="0" formula="uLUuuIylTEe2oSRGIoyAjg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="K2KBjRqpgEeKIP-8I7xdBw" name="Fraction mucosa" description="Mucosal fraction of regional intestinal tissue mass" persistable="0" isFixedValue="0" formula="ae_T2o-Rvkq0V2q3z_Cp_g" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="DQda9--QMkWjTjqf_ipU7g" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" formula="NWe2kUy_l0SV7U8WJzgx2A" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="moztukEmPkCs8kZwSncEoQ" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" formula="Em2K95NNx0-oObcCmvNcYw" dim="Nanolength" quantityType="0" />
-                        <Parameter id="GgfJQY4b30qKeLtmgVMuww" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" formula="kX4yMZYgq0qKRUbDhgfNGw" dim="Nanolength" quantityType="0" />
-                        <Parameter id="w_tfL1tvp0eJZVJxOeTCKQ" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" formula="vli0bQ4jVkiioXIoZBXR3g" dim="HydraulicConductivity" quantityType="0" />
-                        <Parameter id="3kQvIFqUJUaB8oOGKdWyPQ" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" formula="_HXJq5cvPUGkCakpb0HT5A" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="U-2KKpa68UOthiYS3ZQw3Q" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="dMXjHTiIb0ua-iVnNPkL5w" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="sWUonzIfjkKZ7JYyVlVvbw" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="aJC0jCS2L0mQ04lk4IyKtg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="FqMILY1iu0Wz2o0eqOQ1Rg" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" formula="Mldh6SEuf02eQTuYhsuXig" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="ecBw6dnWCEm4SWsZD5-oZQ" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="BsWozv1Zq0iqt4fGNTonsQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="1t4x1_YB4UaANlMz5L_Z1g" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="Z6WtfDY0g0yD-9Pr4Xa-tQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="0YvOpD_93k-lsGq7kKrkKw" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="s6RlD__N-E2PEe9FBGhtnA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="Mp3WQob3mE-nGzDFL_jn2w" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="-X5BJIf7r0mpyfU4Rtqfqw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="lyDs126ln0m-Tx1ej32slw" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="o6hXl3uZu0WxXL8MYGeYcA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="IEjkvpJc5UmdrOR0XGBsRg" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="rgsV-K7e506UDl81R7SwFA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="MxHZc75i5E67XsADH2Nanw" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="fkHxoyjNd0KsAGTge5U-YA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="cU_7sQDFD0qHosKajvnxXw" name="Microsomal protein mass/g tissue" description="Microsomal protein content per gram tissue" persistable="0" isFixedValue="0" formula="1vM_Ewkgiki-5lA34ciAbw" dim="MassProteinPerTissue" quantityType="0" />
-                        <Parameter id="mH7oPaDB80qVkwkKKWONcQ" name="Protein mass/g tissue" description="Total protein content per gram tissue" persistable="0" isFixedValue="0" formula="31-cgKOaCE-Yy6MoepwSuA" dim="MassProteinPerTissue" quantityType="0" />
-                        <Parameter id="dlGmaspvxE-IGnwEWOHHwQ" name="Number of cells/g tissue" description="Number of cells per gram tissue" persistable="0" isFixedValue="0" formula="ZykkB0eN2EqPzYbtBy4VkA" dim="CellQuantityPerTissue" quantityType="0" />
-                        <Parameter id="I-szDxXfP0iHthR0MyPBeQ" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" formula="qMk5UPi39Ey78SkSjlkmRQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="Lsko3nYq60mAjW2lyjdQZg" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="2v1VlyZlK0eaX3ZvisGCvQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="vRJ4J2MqFkOFlds1B78uog" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="UTqSOSMrM0-nT2lsnIR8Ag" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="fvkI-MesI02rjHZtSonYNA" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="YKXGlzbasUujJnjN-9-tfg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="AZs8d9-h5062Lm_FhgI4Rw" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="_MHZtDfQoEqYPKvTme_exA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="vadevjv9pUuQy3Ph8Gn1lQ" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="evCvZq4Bm0-455MrPIB5kw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="k3WA5gXUIEeQRxHgV_C29A" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="tkHPU73HTEqQfyi-NHVr7Q" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="nRoIraXLS0KJRx5lR67dgA" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="oF3CLEmNaEKchG8CH8vjQA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="n1LA5uxII0isluSScDapgQ" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="upzjSR22lUyPPnP5oF271g" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="pWZaldo5ukW6lxWBAcqk8Q" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="9ByaQM73o06nhzh0qIc1cQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="EFJdUMP6H0efMF-aXIoSog" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="Wb9k7GSw0UOG1_SsD-jaSQ" dim="Dimensionless" quantityType="0" />
-                        <Container id="lD1ALP8VY0eUEmlEri8jWA" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Plasma" />
-                            <Tag value="ColonAscendens" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="arEbUiRTx0GzCSQEUoNGpg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                            <Parameter id="iJX8WjUla0GTxjKeygqItQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" dim="Volume" quantityType="0" />
-                            <Container id="Y_5mZIDpDkqGfHHYMwdtOg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Tags>
-                                <Tag value="MoleculeProperties" />
-                              </Tags>
-                              <Children>
-                                <Parameter id="qeAtMtqL-kaEOcUHxlwk5Q" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" dim="Dimensionless" quantityType="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="61Zi-_Bk6k2KAceYwRaXCw" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="BloodCells" />
-                            <Tag value="ColonAscendens" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="6-r4kKF3BkC6TkI3BEXOeQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                            <Parameter id="XMV3inmKfUmROQJzx7qNpQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" dim="Volume" quantityType="0" />
-                            <Container id="0A_nact7oEG88fAATIpr7g" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Tags>
-                                <Tag value="MoleculeProperties" />
-                              </Tags>
-                              <Children>
-                                <Parameter id="8JyfoXFBcUile5VVD5m_Gw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" dim="Dimensionless" quantityType="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="WxXF7NOOo0S5mxz-XY-A6g" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Interstitial" />
-                            <Tag value="ColonAscendens" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="ou4EwTglIUW7kq_dWgslAw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                            <Parameter id="Ewu22b42zUiDoO8XO-bIBA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" dim="Volume" quantityType="0" />
-                            <Parameter id="4ZhbFTl9CUG1twTP_EDG5w" name="pH" description="pH" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_pH_INT" dim="Dimensionless" quantityType="0" />
-                            <Container id="HDC2W4UeIEGZ7o3YCVQO3g" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Tags>
-                                <Tag value="MoleculeProperties" />
-                              </Tags>
-                              <Children>
-                                <Parameter id="NA9u-odH8ESWOmdJ_n5R9A" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_colasc" dim="Dimensionless" quantityType="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="hvfn0Cc3kU2or6mhw1stFA" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Intracellular" />
-                            <Tag value="ColonAscendens" />
-                            <Tag value="IntestinalSecretionSource" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="CkHZRP9YXk-wIVNKI00SNA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" dim="Volume" quantityType="0" />
-                            <Parameter id="v8BFPeavpUChL3udN1CbOw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" dim="Volume" quantityType="0" />
-                            <Parameter id="QdnLdxoSNEK6MKn-_bO-Dg" name="pH" description="pH" persistable="0" isFixedValue="0" formula="m1F5YlU3m067ZPefVUS1iw" dim="Dimensionless" quantityType="0" />
-                            <Container id="EQnzVWc6sEqt9uv-1x6kPA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Tags>
-                                <Tag value="MoleculeProperties" />
-                              </Tags>
-                              <Children>
-                                <Parameter id="YzOVLKGevkCUFbXU0Wko5g" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_colasc" dim="Dimensionless" quantityType="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="ztbD_SuG2EGjgXYAVDMKJw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                          <Tags>
-                            <Tag value="MoleculeProperties" />
-                          </Tags>
-                        </Container>
-                      </Children>
-                    </Container>
-                    <Container id="Vqrl1fxS_0OE_fPu7_z0JA" name="ColonTransversum" description="Colon Transversum" icon="ColonTransversum" mode="Logical" containerType="Compartment">
-                      <Tags>
-                        <Tag value="ColonTransversum" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="UbtG5SI1DkKL2JLd97_WXA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="MucosaVolume.VOLUME_MucosaColonTransversum" dim="Volume" quantityType="0" />
-                        <Parameter id="OEa7C4qSu0yc__PjjZq03g" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_Q_lymph_mucosa" dim="Flow (volume)" quantityType="0" />
-                        <Parameter id="ljcPu2thKkqICmf8llOYfg" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" formula="VascularEndoVolume.VOLUME_VascularEndo_coltrans" dim="Volume" quantityType="0" />
-                        <Parameter id="tUXNewjef0iadtVQcg2hAQ" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_J_iso_Mucosa" dim="Flow (volume)" quantityType="0" />
-                        <Parameter id="9kmYbR1cd0Oce26Y4cARhw" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_Q_mucosa" dim="Flow (volume)" quantityType="0" />
-                        <Parameter id="BxW1AG9UdEexF-o5wP9F6g" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_f_cell" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="5sE40M8s-U6CXSdN21GoVA" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" formula="CPX9ZTghMEO9-B0vywJ_gQ" dim="Density" quantityType="0" />
-                        <Parameter id="OtDd9ah4MEWGsPMoftenhA" name="Fraction of regional blood flow rate" description="Regional blood flow fraction supplying the mucosal tissue of the segment" persistable="0" isFixedValue="0" formula="nqNO70aqQE-x7lXjiUElxw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="-LMT030XG0yrnarOzdcIBQ" name="Fraction mucosa" description="Mucosal fraction of regional intestinal tissue mass" persistable="0" isFixedValue="0" formula="QQSBCW-52kW-tEfmhlW_mQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="G2eFkvOkmkKQrBVwuw1eGw" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" formula="MFLOcvGySUuBIumOxDIPng" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="6G_swuyq006ajdmalfSGzg" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" formula="498zuJrReU-JZxWhM3gnsw" dim="Nanolength" quantityType="0" />
-                        <Parameter id="HrYwKxiUdkKS7aeTMEqL0A" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" formula="zPHn4P3pKUaWxt4nF8ZY6g" dim="HydraulicConductivity" quantityType="0" />
-                        <Parameter id="KTv5kpEzQEWM3eTLNFeFAg" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" formula="uzgF3v8Ns0OcoeLiZuSVEQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="R4SvX1p0b0uoRGf19g724Q" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" formula="FwRq5qggC0q1FGUMD5rrVQ" dim="Nanolength" quantityType="0" />
-                        <Parameter id="XlTzLKJTSkCfj_JyQt9zoA" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="CseW9-MRIkCDoAdWthlfYg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="KyrYBlpKiEOV60JJWOeUmg" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="RVulzilpJUOIc6_jtAepqQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="9NfaxcG9cUmobUb15zSQTQ" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" formula="1VTUTgK_5EWxDUm1nVu07Q" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="j6r8zZaf50SFpJK8qGx3-w" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="OoGauEcAEkqI-Keip2Yz5w" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="NhGjs_IhvEKhW352Pyrc1Q" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="WZuOsY1qU0Kt7nFNJxHbxQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="dXF5soeAbk-hpXPyiLgC2Q" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="r7pnbUZl7U6LQ0KU0WSBtQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="im0rKFwlU0ChdISAPewA1w" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="EXfhajkXEkaoC4KzztRRJw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="qCM5_3Qv0ka29kZRQ8H-TQ" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="9_UhTYej3Um4ZodxxEDwxw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="oofZo9yDeEeuCyVy2xpPqA" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="osfGkT7CYUOGarHsRxEQog" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="5clkC42E3EWqdIGlXckxjw" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="gnSi4_cOIkmbHpwKY2UlTQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="ybqO_vZitkekhVz28qkB0A" name="Microsomal protein mass/g tissue" description="Microsomal protein content per gram tissue" persistable="0" isFixedValue="0" formula="4VeViz29T0Sd5308aJlFHQ" dim="MassProteinPerTissue" quantityType="0" />
-                        <Parameter id="HwBNMifCy0i-nIsTQ8clAg" name="Protein mass/g tissue" description="Total protein content per gram tissue" persistable="0" isFixedValue="0" formula="9Jx_B-rUsESP6AWY0mt4lg" dim="MassProteinPerTissue" quantityType="0" />
-                        <Parameter id="JuEOPyjdmUayGBDgnvwUoA" name="Number of cells/g tissue" description="Number of cells per gram tissue" persistable="0" isFixedValue="0" formula="Yb8EoK5ibkuZV4etMITgpg" dim="CellQuantityPerTissue" quantityType="0" />
-                        <Parameter id="a4l9M5UGN06PmroSQYb_vw" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" formula="MeycAz_hg026X0PvATLDBw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="E5ocpQuzQEC0NRJBcQdxZw" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="_u74PG1eyUeUWSkewlylyQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="SHHvVfxqqEuit8O6gfWRmw" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="94LnYKVjf0Wj4x25zCjEwA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="HPxAPtYLn0KyYFP9qVdA4Q" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="0hIukm0ziE-QCQwVNhHT6Q" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="gsMW4_M9yU2U1k3DOkM-oA" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="A3lTBeJDaU66oe-6QjS2yw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="MeJ-TZtU5kuL32lE38-jOw" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="FqZVUo08jkGZafLGISOKFg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="eRlylkGiGUefLJQk-puj6Q" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="jJN7WWF03UmZbQvVIv23Hg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="RU4XCI0NpU2dWnDyJ4BQkg" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="nKPWN4e64kWsptbBDpa2mw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="XWuknjVFpkifaKtCMEN10Q" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="vh6afEfHb06QurbjYx6C0g" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="HwollqwkeESRNERfDCft5A" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="YE9hPXB2YU6C6rOYJAn6PQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="YDFuQ-hyjk2PLs5_Hrw-Qw" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="7NuO35FZIE2Zuo_MOCJeLg" dim="Dimensionless" quantityType="0" />
-                        <Container id="iPvRkWZ76UCcWPzFPJlJxQ" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Plasma" />
-                            <Tag value="ColonTransversum" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="yHc5sU-1PEGXQXILL3DkAA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                            <Parameter id="lGQymxzreEKZHbEZeCLjVA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" dim="Volume" quantityType="0" />
-                            <Container id="Q5pdvN0dLUKbWBK15FcFHA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Tags>
-                                <Tag value="MoleculeProperties" />
-                              </Tags>
-                              <Children>
-                                <Parameter id="nDUf7YIzqUCy9k_MHMTfXw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" dim="Dimensionless" quantityType="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="k3eDZxhGcUSx99US8MzGjg" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="BloodCells" />
-                            <Tag value="ColonTransversum" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="lID4GisrG0mMtQnIinHbUA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                            <Parameter id="lAMS2XkSW0yv2KoTrZY47Q" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" dim="Volume" quantityType="0" />
-                            <Container id="1q8HUuNrTUWXFB8qbaRiRg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Tags>
-                                <Tag value="MoleculeProperties" />
-                              </Tags>
-                              <Children>
-                                <Parameter id="oLs7xG6QqkKrs0NqBVxXvA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" dim="Dimensionless" quantityType="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="wRo9qjn_cEa29Q-7tBy4zw" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Interstitial" />
-                            <Tag value="ColonTransversum" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="UgoMJ8AqiEyR-V5Ua9lekw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                            <Parameter id="47cBeOEsSEGWa4WFpC48BQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" dim="Volume" quantityType="0" />
-                            <Parameter id="9Xtb6e9Kr0a0P5ugtPfU8w" name="pH" description="pH" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_pH_INT" dim="Dimensionless" quantityType="0" />
-                            <Container id="gV_o9Xn5yU2bmSoqikF69g" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Tags>
-                                <Tag value="MoleculeProperties" />
-                              </Tags>
-                              <Children>
-                                <Parameter id="SAI11vMFPk6ZjqePtHnwwA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_coltrans" dim="Dimensionless" quantityType="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="x1kSFFO9_kq-91UQyO7UCw" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Intracellular" />
-                            <Tag value="ColonTransversum" />
-                            <Tag value="IntestinalSecretionSource" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="cyzMA1UoFEuSIXZQD4bKiw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" dim="Volume" quantityType="0" />
-                            <Parameter id="7A7xIYhx3Ueq1V7C70K0sw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" dim="Volume" quantityType="0" />
-                            <Parameter id="d0I2xhfWtE-LXifJhCpe1g" name="pH" description="pH" persistable="0" isFixedValue="0" formula="AtmaL0eiJESBrkPS7qqDHg" dim="Dimensionless" quantityType="0" />
-                            <Container id="vcvZSgu_DE209i1tY1mzPQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Tags>
-                                <Tag value="MoleculeProperties" />
-                              </Tags>
-                              <Children>
-                                <Parameter id="RTr_5yNdDU2pFZVFb53MJQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_coltrans" dim="Dimensionless" quantityType="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="iTH8TUpYJ0CzncM2oCbr_Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                          <Tags>
-                            <Tag value="MoleculeProperties" />
-                          </Tags>
-                        </Container>
-                      </Children>
-                    </Container>
-                    <Container id="AQP7A4TNjUmGKJs54kXc-g" name="ColonDescendens" description="Colon Descendens / Distal Colon 1" icon="ColonDescendens" mode="Logical" containerType="Compartment">
-                      <Tags>
-                        <Tag value="ColonDescendens" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="w0EeU9LfxkeovLicBfSfyg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="MucosaVolume.VOLUME_MucosaColonDescendens" dim="Volume" quantityType="0" />
-                        <Parameter id="_NVBE6CShkOl7RE_M6rC1Q" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" formula="VascularEndoVolume.VOLUME_VascularEndo_coldesc" dim="Volume" quantityType="0" />
-                        <Parameter id="ek58m94yLUeejNDMjpSjRw" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_Q_lymph_mucosa" dim="Flow (volume)" quantityType="0" />
-                        <Parameter id="D3PVn77RNk-EPK2kPUu4kA" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_J_iso_Mucosa" dim="Flow (volume)" quantityType="0" />
-                        <Parameter id="94wXPcCb7Ua5O-L7ulTuQw" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_Q_mucosa" dim="Flow (volume)" quantityType="0" />
-                        <Parameter id="phJllIFMvEGqsvXSmQD95g" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_f_cell" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="FHSbzho9v02Jod0oHxP_CA" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" formula="yJrBkOVkXUO-5j0NTFyLvg" dim="Density" quantityType="0" />
-                        <Parameter id="5cFZiaxfg0mSoozhMfwSCA" name="Fraction of regional blood flow rate" description="Regional blood flow fraction supplying the mucosal tissue of the segment" persistable="0" isFixedValue="0" formula="xJ1EvlwOGE6xR5rm8i344g" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="IlZrzECtcE2TvuwO8WEphQ" name="Fraction mucosa" description="Mucosal fraction of regional intestinal tissue mass" persistable="0" isFixedValue="0" formula="ImZO1nbo8kmMyxqoYCUwSg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="WlTgJvYvYk6iwzQ2YZjYgw" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" formula="E0HMUE5cgkG6utjbbMdJPQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="PArvitB6B0muaV0qu_lKfw" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" formula="VoMsSPBxbUuQFv7sPHJ4vQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="YVGgvmPg_k-FiZh4ClidAQ" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" formula="MeryPgkxoUKEEwin__A_zg" dim="Nanolength" quantityType="0" />
-                        <Parameter id="1xj12Q5nUk6EQkOX_PfwrA" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" formula="DItqQydnmEmaJBVPP1qSng" dim="Nanolength" quantityType="0" />
-                        <Parameter id="VbNU_JuHDU6K8hpcmnhOcA" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" formula="mtNtihhwgEayHiVN3fs09g" dim="HydraulicConductivity" quantityType="0" />
-                        <Parameter id="iwcLshAUhECI-cYzzQLJ-w" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="AIOBZCsQWk2uxwyJkBHlQQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="YOc9om3Ms0KQke-83OjTZg" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="Pmv8zSTPJEyQ9MEb7BkLSw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="CnxEc-pAukSl3FN-qiwDvQ" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" formula="raO32uCGJ06aJxJZZFqnaA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="LcBLlI7EqU-ufH4kJWseIA" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="PRNJH4YAgUScLx1RVJf5WA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="KjqRWeNqxUiJj6WhqKRojQ" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="vStGkaJAREqG7ksvxgOh8Q" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="Y97YPtb63kybv78dOdzt8Q" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="KMc0rqQgN0GaSCtNeQJoVQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="-b037bURZEC5h38Fvlm16g" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="7keE9m65KUSMSKnWuxK1Zg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="l7HT2xEfrkCxZmXbm-GFdA" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="Yk5pm3VtKEyI_uJWURejHQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="jJ7ryrLz70KB7NtKB97i0A" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="SiN_5kpo00WTPeI8hsBuOg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="5Me-UYo3sk66YlIy1oA3Ww" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="favjEIlaaEC0v7ehooQmKQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="CIGkHj-eBEOYcgdful6kpw" name="Protein mass/g tissue" description="Total protein content per gram tissue" persistable="0" isFixedValue="0" formula="TG93se2BXkquf4axnHrDvg" dim="MassProteinPerTissue" quantityType="0" />
-                        <Parameter id="95wBs_qlBEWF5W5hyXOSVQ" name="Number of cells/g tissue" description="Number of cells per gram tissue" persistable="0" isFixedValue="0" formula="Tmic4OVL_0iWhaW-dZMOXA" dim="CellQuantityPerTissue" quantityType="0" />
-                        <Parameter id="TxMkLAV-QUGRmZaoQ5tWTQ" name="Microsomal protein mass/g tissue" description="Microsomal protein content per gram tissue" persistable="0" isFixedValue="0" formula="mnFiU2dStke_Kav_BbkQag" dim="MassProteinPerTissue" quantityType="0" />
-                        <Parameter id="9KpCitYsp0O9zM5lyoxMXw" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" formula="X1YjjGt3ZUOmYcepJSFh_Q" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="YPVSzAK1Mkueg-d-iboc3g" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="F43oV_Y210W2IsIOyg-pIw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="k-607VgJxUKV49uACjYjvA" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="W4fdNMlsZE6OIDllOyJClg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="3xoIkbD95kSUTShCtL7Ipg" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="DyKzoKLyUkyP97S5G2nJnQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="HD2610YvD02J_vfjobM72w" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="JXoCaAKg80CvR0ytJpIvQA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="WK-X465kr0eLtdB3HY3dUQ" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="S7ubBEKjOUevgecCDP6ZIA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="FuBBwBvvSkGmkQ6Fklpv_w" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="MVIWwKkekUO1nUVE116zdA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="yPMRpCB3AkCuwiW1EZ-E7Q" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="zGE9l2ryAEWTfOW7UkLedA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="wM0mIuc2S0OtuQgDWp-08g" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="33llHh66WU2oSF93VVZmCA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="3gMgiy0sDEegTWJYbFgy3w" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="R50F0ISQUEC7x2lAgu2PlQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="8FMW3BSlzUWqc1QIwkk4MA" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="_-DOiG7qaUOMqU45uGbpGQ" dim="Dimensionless" quantityType="0" />
-                        <Container id="z4zcH_HhW0yr4B9Cwg_sfw" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Plasma" />
-                            <Tag value="ColonDescendens" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="1IWEpv9jiE6pkWg6x2Agew" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                            <Parameter id="i-t-4JPxeUC8tMpLeZ31pA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" dim="Volume" quantityType="0" />
-                            <Container id="765chGR1eEyqH7zK9TGzPw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Tags>
-                                <Tag value="MoleculeProperties" />
-                              </Tags>
-                              <Children>
-                                <Parameter id="VAl9NewvK0-WLXdMYLe8Fg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" dim="Dimensionless" quantityType="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="XK3vUE0RlU2Uq4VMEUyDFQ" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="BloodCells" />
-                            <Tag value="ColonDescendens" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="sV49YOcP6Uy8lKwYzfHHLw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                            <Parameter id="uowTUSQo1kCeW9j_fDo2KQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" dim="Volume" quantityType="0" />
-                            <Container id="TGSdqJGwPUmQ_ez8GTSciA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Tags>
-                                <Tag value="MoleculeProperties" />
-                              </Tags>
-                              <Children>
-                                <Parameter id="gXY0cAic0UuzBMQjJIFNTA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" dim="Dimensionless" quantityType="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="_DlcNLs4P0-oyPZTTygREA" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Interstitial" />
-                            <Tag value="ColonDescendens" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="uKD_1Cw53UepJd3mvheXCg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                            <Parameter id="7IyhomR3vEu5A5BK-wCBMw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" dim="Volume" quantityType="0" />
-                            <Parameter id="TbIYCXQ0t0erTI4FDgzuUg" name="pH" description="pH" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_pH_INT" dim="Dimensionless" quantityType="0" />
-                            <Container id="pph7frUB3EefZjXN5K3Q4Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Tags>
-                                <Tag value="MoleculeProperties" />
-                              </Tags>
-                              <Children>
-                                <Parameter id="deokCTvkbUu0yklDs8p_EA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_coldesc" dim="Dimensionless" quantityType="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="vZZk3ffGfEecawifpPNcpA" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Intracellular" />
-                            <Tag value="ColonDescendens" />
-                            <Tag value="IntestinalSecretionSource" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="mQUUlnVbIU-i9q6konKDNw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" dim="Volume" quantityType="0" />
-                            <Parameter id="YHbdBFsElkmIxVmezRM3nA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" dim="Volume" quantityType="0" />
-                            <Parameter id="dvh74jKzEke_GD-FLyIhXQ" name="pH" description="pH" persistable="0" isFixedValue="0" formula="soHSltP8Vk6p66iQ71Ae0w" dim="Dimensionless" quantityType="0" />
-                            <Container id="o3Scsieks0aEx0cWRyjI8w" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Tags>
-                                <Tag value="MoleculeProperties" />
-                              </Tags>
-                              <Children>
-                                <Parameter id="_U8Rrg_dNEGgp3PoJo407g" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_coldesc" dim="Dimensionless" quantityType="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="IDIk3Wx8XEWDOgJtvhDmkA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                          <Tags>
-                            <Tag value="MoleculeProperties" />
-                          </Tags>
-                        </Container>
-                      </Children>
-                    </Container>
-                    <Container id="BrY804I5OkalWB51Lpq4Rg" name="ColonSigmoid" description="Colon Sigmoid / Distal Colon 2" icon="ColonSigmoid" mode="Logical" containerType="Compartment">
-                      <Tags>
-                        <Tag value="ColonSigmoid" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="YF3VJn-pD0Ca-ePn6Ee4TA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="MucosaVolume.VOLUME_MucosaColonSigmoid" dim="Volume" quantityType="0" />
-                        <Parameter id="C1RChTMr-06ZtYlRZyLn0Q" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" formula="VascularEndoVolume.VOLUME_VascularEndo_colsigm" dim="Volume" quantityType="0" />
-                        <Parameter id="qWb0M-7_5U6X3P6fyv7Pwg" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_J_iso_Mucosa" dim="Flow (volume)" quantityType="0" />
-                        <Parameter id="aH23bTcaG0uRP0tHfBrJRQ" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_Q_lymph_mucosa" dim="Flow (volume)" quantityType="0" />
-                        <Parameter id="4wLaQDTEO0O-RyCHKrcQQg" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_Q_mucosa" dim="Flow (volume)" quantityType="0" />
-                        <Parameter id="8kx1aUovokKXCW1S-dPS7Q" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_f_cell" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="2uCbZR_6X06FFI4ugCbiog" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" formula="ZeEbFGfAUk-9ywwsUk623g" dim="Density" quantityType="0" />
-                        <Parameter id="QRj4E4rjGEqtpfbz7FZOdQ" name="Fraction mucosa" description="Mucosal fraction of regional intestinal tissue mass" persistable="0" isFixedValue="0" formula="AcIhdBs6BUaXiaP3qDWFLQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="yNzvn2q8S0OQ25CjcsXA-Q" name="Fraction of regional blood flow rate" description="Regional blood flow fraction supplying the mucosal tissue of the segment" persistable="0" isFixedValue="0" formula="RVYUoRG9Ok6YtWPuaNOOfw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="84UHeu8o6UWrH8HfoD8QiA" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" formula="txnl7hcmQEiJx0MzHgtXNg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="5YdQh-UNAki-yNkkdmRbEA" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" formula="JShe6qd-KkCqMz7rG6YU9w" dim="Nanolength" quantityType="0" />
-                        <Parameter id="d9aH-_9gW0WoAxBHLFguZA" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" formula="KHBq42SsikyYXmcfsfBH6g" dim="Nanolength" quantityType="0" />
-                        <Parameter id="2-MnsBLFsUaX95kEeaunNQ" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" formula="qoXDlg_s606JjcSYC0jvLg" dim="HydraulicConductivity" quantityType="0" />
-                        <Parameter id="ofxHZBUTRE-dKdbazKH8wg" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" formula="UURQ0q6eaEKcK0BYeA2Sew" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="bF3RgsRWMUG5xwLRYnJhew" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="bBaXjY-wBEaFVuu6TjIFqw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="SJBsyfzLNUmnvY30sY2IZQ" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="Ie-7Wum55UCIMc-OOp_cNA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="gV_BFAJI6U6nzHLYMZ_a-g" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" formula="CsVFSwvtFUCWD4CEA21iQQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="j3uXkLnAGk-qQQncsgWmXg" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="1YmgphCzU0KoMOLlvjbhpg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="pFMe4-DuIkOZy4RhC9cQbw" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="D239xgkL3k2OOY-YD1g-mw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="UJGHxDG-OUupPQKrdiJsWw" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="cDu2Uz9FU0GEZGI-fl_QyQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="dp4HXDpDJ0y0uyp8pcT0mw" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="BThF6RhbFUOfFGcFOhwpcg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="Q2PCP06Xl0eBSphsjTLnkA" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="ZsRInGijz0GcLc8Pp3VnXg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="za_hMAcphkym0FfGHtQyOQ" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="XE6IXqrkSkOvdRBd-qlUkA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="aIH_M0humE2pzwDGDu2wyA" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="9BmbZ_TzhEmU6eIDFy1CLg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="gmpsX3y_rUWtanB6GGct1w" name="Microsomal protein mass/g tissue" description="Microsomal protein content per gram tissue" persistable="0" isFixedValue="0" formula="haPnuinCw02L_bx28bHTYw" dim="MassProteinPerTissue" quantityType="0" />
-                        <Parameter id="sLJmaPvCWkmdc7pC4JICMQ" name="Number of cells/g tissue" description="Number of cells per gram tissue" persistable="0" isFixedValue="0" formula="CGNO3msm2EWrwywtvKMEog" dim="CellQuantityPerTissue" quantityType="0" />
-                        <Parameter id="fOXl0LS2hESfjyOuGhkRsA" name="Protein mass/g tissue" description="Total protein content per gram tissue" persistable="0" isFixedValue="0" formula="pPx73JxRPkmzYtkgUxJI1Q" dim="MassProteinPerTissue" quantityType="0" />
-                        <Parameter id="-n7TyjYFeEG2b6dq66tIUQ" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" formula="4cg2OmSb_UGWyvWTYz45lw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="YA_XYs8ip0anJx0x-rJ2zw" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="5S4aIGUX60uud7tblxPK4A" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="b_fvlvOG5ky3RwB2-lfr0w" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="iZ-BzpNVs0CyBaFaHw3DrA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="7RhrE_I_Zky465FQF96Tjw" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="DTlyfbGq9UiQUkSL2fxj8Q" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="jH5T7qA7IEGzrdPrMdvC_Q" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="eaiMwfR5ok6-bdZXSX94bQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="snwJRa5Z0UCvZoMfY0j-iA" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="_DicYcX4JE60qvDZlAF-NA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="v5jAaIsJ9U2Lh6itpj5ARg" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="48eLcGz5f0ufhhfjPZJrig" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="YYJX1is5N0aOOk_kHGpcXQ" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="Sis-gl8R0EqThAijzmorNg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="uJY9MXSpZEyrxFVIMghzdg" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="mwfDqais2U-NU7V2p0t_vw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="BkXuVomPM0uPEFssRnxFQA" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="yRcKufDCWUKwV3eIVfzemA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="y4DfFBJma0u0c8djNOW2tw" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="LdAXih05RE22JI-Ox74MdA" dim="Dimensionless" quantityType="0" />
-                        <Container id="FyoEzv-8O0WMSz47wtJ9gg" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Plasma" />
-                            <Tag value="ColonSigmoid" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="5CyiQZ7uJ0GqDxfTpgsH7w" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                            <Parameter id="o_DiW9wYg0u4szFegve_sw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" dim="Volume" quantityType="0" />
-                            <Container id="Rhd0PuzB3UeJvk-JqRfDIQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Tags>
-                                <Tag value="MoleculeProperties" />
-                              </Tags>
-                              <Children>
-                                <Parameter id="dn9yGmdMw0qGWBiPSdIUqA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" dim="Dimensionless" quantityType="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="Yo5tHCCFQUekhjV8Ghb7RQ" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="BloodCells" />
-                            <Tag value="ColonSigmoid" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="Lmac_VTAH0iCA2rc80lasA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                            <Parameter id="gFrCIEo66k2TVOAYt9pn2Q" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" dim="Volume" quantityType="0" />
-                            <Container id="WrH_l_3YrEO81Ba9ZJhStw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Tags>
-                                <Tag value="MoleculeProperties" />
-                              </Tags>
-                              <Children>
-                                <Parameter id="05ADJUEBCEGhynq1gUYlMQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" dim="Dimensionless" quantityType="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="0V3VgRSNWEK4JG3IV72CEw" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Interstitial" />
-                            <Tag value="ColonSigmoid" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="QCzQEOpjZEGow6R6f0S-UA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                            <Parameter id="h26DWLWliEC1tt9omxY0sg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" dim="Volume" quantityType="0" />
-                            <Parameter id="j3-SMNYCsUOUcfNj1vhQVA" name="pH" description="pH" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_pH_INT" dim="Dimensionless" quantityType="0" />
-                            <Container id="NUTDNXqmvUibyHIHvheiuA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Tags>
-                                <Tag value="MoleculeProperties" />
-                              </Tags>
-                              <Children>
-                                <Parameter id="i27J7bY7P0-Aun4lONGP-Q" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_colsigm" dim="Dimensionless" quantityType="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="7Y9A4sqt2Eig287pq_CdWg" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Intracellular" />
-                            <Tag value="ColonSigmoid" />
-                            <Tag value="IntestinalSecretionSource" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="MpioryiKBUuMTMRslQbEXQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" dim="Volume" quantityType="0" />
-                            <Parameter id="4RsbKTDD4kGdAYDDhOrfgw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" dim="Volume" quantityType="0" />
-                            <Parameter id="5TZfuyFFKkWnFuPOTy6T7Q" name="pH" description="pH" persistable="0" isFixedValue="0" formula="j8W5G2SFIUWfrCJKjU4IAg" dim="Dimensionless" quantityType="0" />
-                            <Container id="WOAS4GZOdUiW3QD-2gz1Mg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Tags>
-                                <Tag value="MoleculeProperties" />
-                              </Tags>
-                              <Children>
-                                <Parameter id="cbrbyw5SAE6y98t1kilb5Q" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_colsigm" dim="Dimensionless" quantityType="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="uWdPH0ErmEywhG3-dPuvnA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                          <Tags>
-                            <Tag value="MoleculeProperties" />
-                          </Tags>
-                        </Container>
-                      </Children>
-                    </Container>
-                    <Container id="aOGRJ9p5DEaP8zlIYdXvYQ" name="Rectum" description="Rectum" icon="Rectum" mode="Logical" containerType="Compartment">
-                      <Tags>
-                        <Tag value="Rectum" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="DCCn8OqJNkajwmh8kIncXA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="MucosaVolume.VOLUME_MucosaRectum" dim="Volume" quantityType="0" />
-                        <Parameter id="uYzTrPtXM0CYrcoGL0Tlqg" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" formula="VascularEndoVolume.VOLUME_VascularEndo_rect" dim="Volume" quantityType="0" />
-                        <Parameter id="FUxF-o1Q2UCuEEVe5BoddQ" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_Q_lymph_mucosa" dim="Flow (volume)" quantityType="0" />
-                        <Parameter id="Uhsfl3xGAUGjXB5s2_gpvA" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_J_iso_Mucosa" dim="Flow (volume)" quantityType="0" />
-                        <Parameter id="wPUVmvNO-0WQ52p8nx4yQQ" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_Q_mucosa" dim="Flow (volume)" quantityType="0" />
-                        <Parameter id="te9uR_zl_kOQeYIDD77KBg" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_f_cell" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="HX3wE4AmMk2I8MV-jVDslw" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" formula="qB9tzy1Ah0yOTA4hsts8vw" dim="Density" quantityType="0" />
-                        <Parameter id="iDJ-Qzabr0ecU6ua8N7aCA" name="Fraction of regional blood flow rate" description="Regional blood flow fraction supplying the mucosal tissue of the segment" persistable="0" isFixedValue="0" formula="8dJqQ0GWM0a9xledFEmX2Q" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="SlFXIeXPREONfG5TJn_drA" name="Fraction mucosa" description="Mucosal fraction of regional intestinal tissue mass" persistable="0" isFixedValue="0" formula="KsIQUJ0Uxk-6jn0I-K7bYw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="EvZUET0PQkiGyKJyysgGKQ" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" formula="7R3BP2EOpUOEvD4SM8fbCg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="8xih5pcjGkuMGQYdAfK6WA" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" formula="NBLSNMOR90S5zYWJ61ruCQ" dim="Nanolength" quantityType="0" />
-                        <Parameter id="6q2ROnFWnkGElrMYHjnSpQ" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" formula="SBaoFG9jQUiwAfYXja5C4g" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="RE6lnCmizU-Ubp_IsWODag" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" formula="K-lW0k7bC0C_51_HbMaZpw" dim="HydraulicConductivity" quantityType="0" />
-                        <Parameter id="bw-mVURB40ioPXnezHS9Dw" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" formula="Js1AGuXkDkK1EkpNmM-0Lw" dim="Nanolength" quantityType="0" />
-                        <Parameter id="UL146s2lHEeBxtKLNM0V6A" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="4WsUb8oUsEKKLIwZ6ppnuw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="IbjKiVsupk2J_Hswm7q27Q" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="Luad5gGwfkeMIgxiSDB6lQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="Kc_-IiJTOUKSMk3N2Gy4xQ" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" formula="b2RIwm54C0GVNKKwZtxlLQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="ywRxH3bS7EmhIbF_ysNDfw" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="1DFhSsERDkmMu-sCjpt2SA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="kv5T6-5oHkuYOOxyzeuz4w" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="qnLvn2tYIESbNltdDCNf1Q" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="Uz9uPPiBq0aeAd87temWQA" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="VJwsFr1uZ0KeivGL_bSzSQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="lcC2kJEMIUG2SIrxnq5nAg" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="NIUFNwiHck-DQTQBcLzLEg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="GqUkg2776UW4j6Fl1vP16A" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="FKbrM00osEukUZTNiTlpig" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="jlsH17w3rE-x6a9sY8SiyQ" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="U_oXBhmnn0GzNdULYp-PoA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="Cv_G34hdXEi4AipDomrDyw" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="oqCLn21zsUO7UVbBK4XQaQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="jaonF4fvxEC3QGhhysRd4w" name="Protein mass/g tissue" description="Total protein content per gram tissue" persistable="0" isFixedValue="0" formula="HT4LmPxyWEO5iU82scEtdQ" dim="MassProteinPerTissue" quantityType="0" />
-                        <Parameter id="dh2JDsryRUWFq9qQMhcq9g" name="Number of cells/g tissue" description="Number of cells per gram tissue" persistable="0" isFixedValue="0" formula="o2Yhuqvxe0G-gKyPsbBG7Q" dim="CellQuantityPerTissue" quantityType="0" />
-                        <Parameter id="Sg6YuVi9_UG_kKT06qPuZw" name="Microsomal protein mass/g tissue" description="Microsomal protein content per gram tissue" persistable="0" isFixedValue="0" formula="TIy4Mc0c7k-KypmG9X9Rbg" dim="MassProteinPerTissue" quantityType="0" />
-                        <Parameter id="ljCk-0VZyEuLvUN_YBpwfw" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" formula="0dTSIyhXNUKo53alskzZjw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="yj_J_9-8HUuPWPaDBHNNVA" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="vpOq-BwKbkCXhqjqjfBbrA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="rsJOvMcOBUqVAT_7W6wSJg" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="Mis68nkvsE6nSum3sSkKkQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="IHTGr7IRb0SBlaRZvffkgg" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="pVjvnsq3wEOI57wwFKvgUw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="Ihd4TEGsKkKpj53sTEkefA" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="uOnady0SbEOWsVAsPcluIQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="u2W2ZnUAME6YEXybuWucpA" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="QD5s3hSwPUec6DxTcdKQlA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="CNo00HSfeUqTkzBIh-Y15A" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="8L3vd4_g-kGlCVXNluxsJw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="61BfRqum5U-V91VdDKdD-A" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="Ao0YPqdN7k2itPv-MoJFhg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="VQbAIZqS9UWK7kN7ttxx9Q" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="NVt3AG4hZUmf_-dHk3omRQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="M-aFVlAEI02NPzy10J7Kqg" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="X4AAPBD_D02RLFNfiOsJkw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="5m_7PHTF90yVKGbapTqCGg" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="JTNnKvJSjEeKDNZ0QZcdLw" dim="Dimensionless" quantityType="0" />
-                        <Container id="eJzNOCYba06diGWhCWqi1Q" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Plasma" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                            <Tag value="Rectum" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="5wRNr_e4dEy7uMJpgL866A" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                            <Parameter id="hWkgVf278EOfkXzFEsaH1w" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" dim="Volume" quantityType="0" />
-                            <Container id="hT8_mLqOq0yfSjzdT-W0tA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Tags>
-                                <Tag value="MoleculeProperties" />
-                              </Tags>
-                              <Children>
-                                <Parameter id="cY009VrEOkutoVksE40orQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" dim="Dimensionless" quantityType="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="udxtFKMRFUe0Mj2-C-W3hg" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="BloodCells" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                            <Tag value="Rectum" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="uGZGk2Q6TkCl2CfwAhSQVg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                            <Parameter id="t2UeM65plUeWkH1cOWBc_A" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" dim="Volume" quantityType="0" />
-                            <Container id="8qi5ZfRHEkWokXP_f4opuQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Tags>
-                                <Tag value="MoleculeProperties" />
-                              </Tags>
-                              <Children>
-                                <Parameter id="WqqNCXrGCUGMDm2O5MVpxw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" dim="Dimensionless" quantityType="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="kneyb0hNCECbiWiCu5EmKA" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Interstitial" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                            <Tag value="Rectum" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="cb_zvsRynUyCauBCD6naXQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                            <Parameter id="fhPbUMXYTUyQe2rB3JMI2A" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" dim="Volume" quantityType="0" />
-                            <Parameter id="Mw901wwsGkqXc0IwhCoxOA" name="pH" description="pH" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_pH_INT" dim="Dimensionless" quantityType="0" />
-                            <Container id="ESL9Nu60OkacK3WdTpsZ8g" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Tags>
-                                <Tag value="MoleculeProperties" />
-                              </Tags>
-                              <Children>
-                                <Parameter id="0vfKlONjCEuuKUDJS8qXtA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_rect" dim="Dimensionless" quantityType="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="QsQ9xRaAm0yGNxNTxJ3PuA" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Intracellular" />
-                            <Tag value="IntestinalSecretionSource" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                            <Tag value="Rectum" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="cmo2IhC1w0eKzk5fY9G__g" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" dim="Volume" quantityType="0" />
-                            <Parameter id="gqfpN_EYWk64i_OjHUfJ5Q" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" dim="Volume" quantityType="0" />
-                            <Parameter id="lGjIm0ZeSEKag8zuVYQUkg" name="pH" description="pH" persistable="0" isFixedValue="0" formula="FtGPsx6f5E2FVVBWmfQb3Q" dim="Dimensionless" quantityType="0" />
-                            <Container id="XM-8s3zflUWqIkMSlFTn-A" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                              <Tags>
-                                <Tag value="MoleculeProperties" />
-                              </Tags>
-                              <Children>
-                                <Parameter id="cSAjNmumxkSukALLyTFydQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_rect" dim="Dimensionless" quantityType="0" />
-                              </Children>
-                            </Container>
-                          </Children>
-                        </Container>
-                        <Container id="JQWqTEzAM020kq-T9gItHQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                          <Tags>
-                            <Tag value="MoleculeProperties" />
-                          </Tags>
-                        </Container>
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-              </Children>
-            </Container>
-            <Container id="qhic4YrGoUSzAXRalzTLrg" name="Liver" description="Liver" icon="Liver" mode="Logical" containerType="Organ">
-              <Tags>
-                <Tag value="Liver" />
-                <Tag value="TissueOrgan" />
-              </Tags>
-              <Children>
-                <Parameter id="e9DAK9XIZESG_5itqIxr4w" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" formula="VascularEndoVolume.VOLUME_VascularEndo_liv" dim="Volume" quantityType="0" />
-                <Parameter id="_6x9SUXuJEeNi-H3Iy_rIA" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_f_cell" dim="Dimensionless" quantityType="0" />
-                <Parameter id="yKRHtCIf1kCyN_9qxnscGg" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_Q_from_Qspec" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="AEVBBdHUREuCvH0QiJXFQQ" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" persistable="0" isFixedValue="0" formula="cVJHApcEv0GpYrbIOJVj0A" dim="Dimensionless" quantityType="0" />
-                <Parameter id="YIvvRNzx3U6Bpek7LfFDTw" name="EHC continuous fraction" description="Fraction of biliary secreted compound continuously entering the duodenum without being temporarily stored in the gallbladder. The fraction of hepatic bile directly entering the duodenum is species-dependent and amounts to about 30-50% in fasted humans to 100% in rats, because the rat lacks a gallbladder." persistable="0" isFixedValue="0" formula="haWSK08J8kOvXzoUqUsrFg" dim="Fraction" quantityType="0" />
-                <Parameter id="Nt_-iOdSa062ttVXrWzf_g" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" formula="530OjyInHE6wAMiUoVY1uQ" dim="Density" quantityType="0" />
-                <Parameter id="aXw_YnYuKk2mfkZJWllFMQ" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" formula="2_Sv2-fc10m5SJ-l2NWrTg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="X9KLV2EfIEe5mYspdLi7vA" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" formula="0_UStKFEyUCaslQ3faWgTw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="y-MNkJSklEqShNCHWTHTog" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" formula="waJMK35eg0GRdfm_jrp9QQ" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="-SEBf5BQRk-mLOqB17LXkA" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" formula="zxetEuUwJ0KaHS82EO7PWg" dim="Nanolength" quantityType="0" />
-                <Parameter id="cdOZiT6BZ0en-LpYWupWvg" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" formula="cjZSxokwEUaDUweTqmqQ_g" dim="Nanolength" quantityType="0" />
-                <Parameter id="CpgtG9kFY0GNyEphX8FaLQ" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" formula="wU9hdxEaKkedXsOtvgQx6w" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="z1OpvQVR_0O36vtyidbA1A" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" formula="M5hoNJx-FEuBNxwGIuWr-g" dim="HydraulicConductivity" quantityType="0" />
-                <Parameter id="uVCCn4bo5kC_7eeGCoffhQ" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="HPuamdZjBU-lNruz_kqZ9A" dim="Dimensionless" quantityType="0" />
-                <Parameter id="ft90W3J0MUKDgWMYpoOxLw" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="2o1LLmg8gkOxrm2v23B8Vg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="yxEnpEmTQEmr0pG42vGzVQ" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" formula="zLnaRtaWoU6xGm9zkJB3Nw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="L6bsztbJzkqXD7wlZ514vw" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="PkaV0qOFDkqCvJwR8pr1Gw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="eLZ3QlaJdEuQxxi4F335sw" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="XO3qCl45nUeefkx4c3tuXA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="8ms_jFpPW0aPz32z2zyRpQ" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="Z5gLY9TCLUCpe_gH4wrRLA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="0Ezs3xTrf0y9k63dYZbxGw" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="q5BWlKTvukCzb9s134octw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="DcJIeW1rVku-hNxuP2CBVg" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="xTOnc8L2oEmaru1oXF_lQA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="PwUSZQ7XT0qdUgutOejBsQ" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="xB59Vz-JAUaIO88eGlmviw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="Txz8ztJqLkmVu0_2TLTFQQ" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="2M2eErqtb06-fbjyCqIqhg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="UtX_Qm5FQU6Hlbx4RydzOA" name="Microsomal protein mass/g tissue" description="Microsomal protein content per gram tissue" persistable="0" isFixedValue="0" formula="yfAUBFCrQESYKzmVc8l-jQ" dim="MassProteinPerTissue" quantityType="0" />
-                <Parameter id="dN2eewbs-EmIXH5CxwvGJw" name="Number of cells/g tissue" description="Number of cells per gram tissue" persistable="0" isFixedValue="0" formula="EA6T4P58Qkufiouk-btHsw" dim="CellQuantityPerTissue" quantityType="0" />
-                <Parameter id="yg0rw1uuykSKU2RNwgJb7g" name="Protein mass/g tissue" description="Total protein content per gram tissue" persistable="0" isFixedValue="0" formula="5nZm_A2ZV0SbJPJt4XFwMQ" dim="MassProteinPerTissue" quantityType="0" />
-                <Parameter id="Eo1rwc8Z2ki-CnLazVqBCQ" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" formula="is9Q6V2G3UKOXzxc1CsVgA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="cdlztU9GhUGym2xr9mNw1Q" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="5JDP8yry-kCVX87BmpwLjQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="BJgJlOLBmEqpUreraMKqiQ" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="c8e0tH8BcE2ewN0oKWUQkA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="P5PlLKnh_EygRy_DXNiKHQ" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="wBVuJHFa_0Ce5ziw16PzVg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="Hb1NCd9LHUOBFKqLe0IC5w" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="QIBITxITd0G_NjUzzgwqfw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="BTDu_Q1ZAEWMoOp_TSzntg" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="Aq0slAxDGkG72ILqPNR-sw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="Ius6WGBnIUihoBKJI9iYKQ" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="4gMUMOHv70eK6XlCVVqDQA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="YUn_QHbjc0ahgQle78TYDA" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="k-yx9MHk-kWs8ZD4GqUIMw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="ycIKYwt9HUydrt3G9FVE7w" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="biqvE3ABoEGUuftH7mp15A" dim="Dimensionless" quantityType="0" />
-                <Parameter id="pv44y8OdUk-H8FKbUlk7HA" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="pHKqGaZi80-suU4GE2WZ-A" dim="Dimensionless" quantityType="0" />
-                <Parameter id="13LOmLvFXkyVmYUGCbFSRw" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="C4Y9Jytr-0S2b6Y5Hdn4kw" dim="Dimensionless" quantityType="0" />
-                <DistributedParameter id="EHG2Ya1gBUePZ5zqdTTEig" name="Volume" description="Volume of organ or compartment" persistable="1" isFixedValue="0" formula="zdZer73MqUeB6CH6HCUI3A" dim="Volume" quantityType="0" mode="Logical">
-                  <Children>
-                    <Parameter id="mbI9Eh_BXEKHU_Em_u-p6g" name="Percentile" persistable="0" isFixedValue="0" formula="k8X-2sOIMEKG94AfpU41MQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="7C3YdnWbE0edf6NBQ3WR6Q" name="Mean" persistable="0" isFixedValue="0" formula="3SfggFtm0UG3fHv-KGsU1g" dim="Volume" quantityType="0" />
-                    <Parameter id="Nm88IIRcq0G2mVTqBezn5A" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" formula="4YDjxL_br0OOSbb-1yckkA" dim="Volume" quantityType="0" />
-                  </Children>
-                </DistributedParameter>
-                <DistributedParameter id="amSChJzklEKJiN06mdF3aw" name="Specific blood flow rate" description="Blood flow rate normalized to the organ volume" persistable="1" isFixedValue="0" formula="Xg93X5wbTEa2pLjbAH_Ejw" dim="Flow (volume) per organ weight" quantityType="0" mode="Logical">
-                  <Children>
-                    <Parameter id="0oLNUXKs9kqzm-G68v-cyA" name="Percentile" persistable="0" isFixedValue="0" formula="9b3YYG18E028AzPMgA7AMQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="FGiolmdVJ0aArTJRxcLzsw" name="Mean" persistable="0" isFixedValue="0" formula="xT0gjzau20WGefgJ7YD1Dw" dim="Flow (volume) per organ weight" quantityType="0" />
-                    <Parameter id="XOL-KMlhYE6v8iZlnRsQIg" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" formula="kzsdKPfRq0SFTnjNUbJXdg" dim="Flow (volume) per organ weight" quantityType="0" />
-                  </Children>
-                </DistributedParameter>
-                <Container id="tyWN5KXnjESqo6psq7MKGg" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Plasma" />
-                    <Tag value="Liver" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="80p2yHm-tUOpqL2yiq69LQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                    <Parameter id="eU-uZze1MEeD4my3786BqQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" dim="Volume" quantityType="0" />
-                    <Container id="7HVjGOo8P0KdKtXlS-PpWg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Tags>
-                        <Tag value="MoleculeProperties" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="dXQ1H32Pg0eVQBvuIGGr6Q" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" dim="Dimensionless" quantityType="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="XysqfO-qtUmc2ATdlw_i7w" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="BloodCells" />
-                    <Tag value="Liver" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="K3HmsphNmUO4i1hAoJVVag" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                    <Parameter id="Utq-AofZdkuRta-cTmCCJw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" dim="Volume" quantityType="0" />
-                    <Container id="He9fnFWwM06bhprXfQe69Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Tags>
-                        <Tag value="MoleculeProperties" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="sSQS6SeKKEK4ZXBCMxtRyQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" dim="Dimensionless" quantityType="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="XC-kBHkNoE-6hvHY_lkMug" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Interstitial" />
-                    <Tag value="Liver" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="twZWa-sItEe_MkvzU2Ebaw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                    <Parameter id="IJx09jo0H0-RfYfGrslv1w" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" dim="Volume" quantityType="0" />
-                    <Parameter id="0k-xcr0xYEiHHuAH3m1HbQ" name="pH" description="pH" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_pH_INT" dim="Dimensionless" quantityType="0" />
-                    <Container id="UNUPaFg9kEKwLcDddWv6Mw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Tags>
-                        <Tag value="MoleculeProperties" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="NxmdPxrb7EaimY3AGhnoKg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_liv" dim="Dimensionless" quantityType="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="isrXizHu7E-JR92xn5ckRg" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Intracellular" />
-                    <Tag value="Liver" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="QbfG2IBkzE2rUHfSUwRvQw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" dim="Volume" quantityType="0" />
-                    <Parameter id="X8wWTVcX1EisVEfv0T4GHQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" dim="Volume" quantityType="0" />
-                    <Parameter id="15AC_cIrcEevnpGKVW3Tzg" name="pH" description="pH" persistable="0" isFixedValue="0" formula="1781kqu0xUSA90IEHJadUg" dim="Dimensionless" quantityType="0" />
-                    <Container id="MpUgFPhieEibRUeZSVYUUQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Tags>
-                        <Tag value="MoleculeProperties" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="rFG9mnbEvkqyWL5zLPkfMQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_liv" dim="Dimensionless" quantityType="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-              </Children>
-            </Container>
-            <Container id="nWJhp3YILkCEDxLnAA8P0w" name="Lung" description="Lung" icon="Lung" mode="Logical" containerType="Organ">
-              <Tags>
-                <Tag value="Lung" />
-                <Tag value="TissueOrgan" />
-              </Tags>
-              <Children>
-                <Parameter id="0zYaqjFhNEWhyKXfhKxi2w" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" formula="VascularEndoVolume.VOLUME_VascularEndo_lng" dim="Volume" quantityType="0" />
-                <Parameter id="t_3hFZ1kNkumsGBCHGszLQ" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_f_cell" dim="Dimensionless" quantityType="0" />
-                <Parameter id="qD_fETVfbkW_udpRC1ToLA" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_Q_lng" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="Oy5Rzr8IzEm6o_ZrOhu-Sw" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" persistable="0" isFixedValue="0" formula="MwFjmfEkUk6I1e8A3915yA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="d9M9mHdKzEia77uX9vEqyA" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" formula="R4XWYBvKGkKRRACW6HmIPw" dim="Density" quantityType="0" />
-                <Parameter id="SAOKsKvea02bZ5EOfIAHUA" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" formula="LuRrvdsPAU2Vy_sqf6P3aA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="JdzvIbLFe0yfMADYxbAe9g" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" formula="2DO5BNgIg0m-POVjhE7B9A" dim="Dimensionless" quantityType="0" />
-                <Parameter id="DR2-TOlRgEi08m__5eEVzQ" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" formula="prhu-5NG10qZ1iTprBaZ6w" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="8v-Cnizbf06KUjSUNP-Iyw" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" formula="740LskbWKUacq010_EtPeg" dim="HydraulicConductivity" quantityType="0" />
-                <Parameter id="rEW40AgQjECEpKxV89uSIw" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" formula="SurfoegdP0u35ee_qwYGTw" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="xWTXlZeJOE6bbQtt57jBrw" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" formula="9oLpgqsBMUaw8028YqRhKQ" dim="Nanolength" quantityType="0" />
-                <Parameter id="5qoCpjV_sEu_we0StY_2Kg" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" formula="Mt6AEL8ftUS-_No8zJRRCg" dim="Nanolength" quantityType="0" />
-                <Parameter id="UC5ibhrYbES383U8AUlEIw" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="a7lf_Z-fZkGTfXQsTiFnGg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="7BiRoBZmq0uiF-HBgk7ODQ" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="roU8HswLlE29j_2MOAjRYw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="s_kXQyCwIk6oPF1CgYJtgw" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="GE7VmuWg70WlQ4WYdcMIDQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="AcZt3U9zjkaaYMc5Pm2uOw" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="WxtXn6H0L0uCYGEDSdFL4A" dim="Dimensionless" quantityType="0" />
-                <Parameter id="yanacq93WUukMDJylhafWg" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="c2dOhRt1LUaVVhnsx4n-qg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="gjknaDs8SkyPpLBhb3JYEA" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="dxVe_gq1nkiva8jWysQ0xw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="FJRvmQRym0-ZVTlptaymbA" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="wBFPVbdXSUS0p-2p2D5Gsg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="7O6pVRAnBk2CM8g-DceQ-Q" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="kMk4lDMp1UiGf_kRQjtHlw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="hiwn0h65TUi7mZIzKfihFA" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="yLTtsMCqpkiWaFHOCKDWBw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="GrZVv8x8EEKq46PYvVTc8g" name="Protein mass/g tissue" description="Total protein content per gram tissue" persistable="0" isFixedValue="0" formula="KhK5iZPz4EmJftg79EZZiw" dim="MassProteinPerTissue" quantityType="0" />
-                <Parameter id="vQw1Q2sv40C_4K2powD4Mg" name="Number of cells/g tissue" description="Number of cells per gram tissue" persistable="0" isFixedValue="0" formula="kTvCNK4kWEGZD0Ulax_vAg" dim="CellQuantityPerTissue" quantityType="0" />
-                <Parameter id="b2LnaoFpI0ezXWUR4RbnEQ" name="Microsomal protein mass/g tissue" description="Microsomal protein content per gram tissue" persistable="0" isFixedValue="0" formula="MBpn7eQ8XEuV0bZMN4KayA" dim="MassProteinPerTissue" quantityType="0" />
-                <Parameter id="Mn3VEliBP0mTaX6ZR88fyQ" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" formula="7o06JR9-FUe9uH-6k896QA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="zhXySxtEF02989m7C3dgYA" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="u4zDyQdUA0-CuzxK28IF7A" dim="Dimensionless" quantityType="0" />
-                <Parameter id="Mh67_TV1Dk-LoiILNDiQng" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="bZksRnexZUe2GA_6sA16Tw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="3nI-jcos5kCQc3nOO4rH6g" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="ilkWcGoTYUe3FUK5d50Vyg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="Rn7vUeyF6kOpncQs9Np3sw" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="2Fd21ijeC0u9BKux56PY6w" dim="Dimensionless" quantityType="0" />
-                <Parameter id="F1txzzHrNkeK6IHOkB2nCw" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="mjN9nNQdW0eS1sDv2phuhQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="Qfaq63MPdUagEZ7b41aD3Q" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="s8Nrg3QjpE-lsDhnGsUHlA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="kpUyX95rfEycyOXY05dyzw" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="kb0G5t0XyEGPhd_dA8DhGA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="HK-Pom_vS0ijGrxdti8Lfw" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="umNUuCqd6ESeA_CvfElZBw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="hwy4Q1jdKUuhu3IT1mgYYw" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="9QGugrZtdk2Enu17Q0Np_Q" dim="Dimensionless" quantityType="0" />
-                <Parameter id="7o9toqH42kuT8KnCty4xjA" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="o_FdnGhGSky_fq_vTpC0vw" dim="Dimensionless" quantityType="0" />
-                <DistributedParameter id="AziPEQ-waUGsL_uPnt9sAQ" name="Volume" description="Volume of organ or compartment" persistable="1" isFixedValue="0" formula="R0aKG0eWWkeYrDE92qlPtQ" dim="Volume" quantityType="0" mode="Logical">
-                  <Children>
-                    <Parameter id="qRpuwGqir0uDriFyXDRPug" name="Percentile" persistable="0" isFixedValue="0" formula="2rcrYjrFTUuHf0_1xpO3Xg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="V97BtnFGR0Wry111Tyol-A" name="Mean" persistable="0" isFixedValue="0" formula="NMvjd7F3lUOGopk2c29MIw" dim="Volume" quantityType="0" />
-                    <Parameter id="3fIoPX5H-kG355dAb0BDUw" name="GeometricDeviation" description="Geometric standard deviation of LogNormal distribution" persistable="0" isFixedValue="0" formula="p4MZ_zZ6bE-zzwg7louqTQ" dim="Dimensionless" quantityType="0" />
-                  </Children>
-                </DistributedParameter>
-                <DistributedParameter id="zFLjaKQl0k2jcEErlDwEJw" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="1" isFixedValue="0" formula="20y0zg76h0e22DWJKc0dSQ" dim="Dimensionless" quantityType="0" mode="Logical">
-                  <Children>
-                    <Parameter id="YvHybzVZV0KyWbdWHtJp4Q" name="Percentile" persistable="0" isFixedValue="0" formula="EC7HmpJIS0Gzl_BkMcorMA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="2U1Gf2lRPE-NMNHZv1nlpA" name="Mean" persistable="0" isFixedValue="0" formula="ppJhkP1ZGkCf4-ZqkD91pg" dim="Dimensionless" quantityType="0" />
-                  </Children>
-                </DistributedParameter>
-                <Container id="WCwWAQPlBEiu2DPVUYG1Zg" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Plasma" />
-                    <Tag value="Lung" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="4_soAx9LVEewTYToq6UrSQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                    <Parameter id="rNU1DUIX4kyysoVkVQMBAw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" dim="Volume" quantityType="0" />
-                    <Container id="hE-B_9PJzke3LeGIH0DNCg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Tags>
-                        <Tag value="MoleculeProperties" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="r_YYgqnjC0CCdw2BgbZ7cQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" dim="Dimensionless" quantityType="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="8Hxc0s3ANEWMmGloh6Tvcg" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="BloodCells" />
-                    <Tag value="Lung" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="CXXTrrJ1bkaemWKsxJkBoQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                    <Parameter id="aedL537p1kWt_on3UP1yHQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" dim="Volume" quantityType="0" />
-                    <Container id="elZZeNklzEm6S8aYIN7yiw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Tags>
-                        <Tag value="MoleculeProperties" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="TLKaqNXqwUODawbn69Qn9A" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" dim="Dimensionless" quantityType="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="vy0-0MwNqkSeHPIm4MJFRQ" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Interstitial" />
-                    <Tag value="Lung" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="-OG-ZFQ20kqOLlY4l9zCOw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                    <Parameter id="sa0EIaTLxky3tJWS3Ojilg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" dim="Volume" quantityType="0" />
-                    <Parameter id="oiCRj4xJXEuF-LVRPCNhkw" name="pH" description="pH" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_pH_INT" dim="Dimensionless" quantityType="0" />
-                    <Container id="4wAUp9e_fU-eVliN2bpKxA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Tags>
-                        <Tag value="MoleculeProperties" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="DufmvGC0mEe24vwaGkGAdQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_lng" dim="Dimensionless" quantityType="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="ui-P-36aJEiMnjRMP4Nx2g" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Intracellular" />
-                    <Tag value="Lung" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="6dwO336lkUaod1KqtiTwsA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" dim="Volume" quantityType="0" />
-                    <Parameter id="Cp-bLQ32oEqBJL9MrMX5Vg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" dim="Volume" quantityType="0" />
-                    <Parameter id="BkMwX7DWKkKg-gCjLMuxIw" name="pH" description="pH" persistable="0" isFixedValue="0" formula="orJJS9juE02_ftbE27bn4A" dim="Dimensionless" quantityType="0" />
-                    <Container id="7Ci8kl3mwUydMrbx52I-qQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Tags>
-                        <Tag value="MoleculeProperties" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="w_6i_hmssEW379j_T-E1Dg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_lng" dim="Dimensionless" quantityType="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-              </Children>
-            </Container>
-            <Container id="L-dRZ0kYRkS7V2l7EorEdQ" name="Muscle" description="Muscle" icon="Muscle" mode="Logical" containerType="Organ">
-              <Tags>
-                <Tag value="Muscle" />
-                <Tag value="TissueOrgan" />
-              </Tags>
-              <Children>
-                <Parameter id="EV-i8ms6g0OsM20J99C9Jg" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" formula="VascularEndoVolume.VOLUME_VascularEndo_mus" dim="Volume" quantityType="0" />
-                <Parameter id="ZJVgkJ8BkkKBX1BW6cLPEQ" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_f_cell" dim="Dimensionless" quantityType="0" />
-                <Parameter id="3Ho2EBnskEGCQHTY2uMeGA" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_Q_from_Qspec" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="cOqNkvYJH0uAy-7mKgnivA" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" persistable="0" isFixedValue="0" formula="ZtC-Aj1ClUqzfg-zdTaScw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="LqWVrdPF-kKwZ11KMnC2kQ" name="Peripheral blood flow fraction" description="Blood flow fraction in organ used for calculation of peripheral venous blood concentrations" persistable="0" isFixedValue="0" formula="yrmySXaccEKGjbajhHi9Qw" dim="Fraction" quantityType="0" />
-                <Parameter id="FQBPJvdE-EaSAyTyR0FBgA" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" formula="ROqYCMWsN0a1RmCz8mgxfw" dim="Density" quantityType="0" />
-                <Parameter id="6jUfZRF7oEGhkYjqxfgReA" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" formula="I1IBKTuwi0Oh3U4FsF9OHg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="hS-W5A0qwEOztTE0aYtkZg" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" formula="DaQ-XKqY9k-vVdWbHqtV0A" dim="Nanolength" quantityType="0" />
-                <Parameter id="XijeobUv0UeyAeHL1vUGew" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" formula="ZfU_86QOiUKOHEAzTIHN4A" dim="Dimensionless" quantityType="0" />
-                <Parameter id="RLRJlY9C0k-xzZfYerQO2Q" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" formula="nKJLsaDg8kayG0ce2-eCZA" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="2tUKG-wwOUK0f6Eo3tCBlg" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" formula="5za3eSlYaUaKZhVEdTFXdg" dim="HydraulicConductivity" quantityType="0" />
-                <Parameter id="t0d9UGFjRESDcZaP4MmMuQ" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" formula="RslWqcRDkU6LR475469cdg" dim="Nanolength" quantityType="0" />
-                <Parameter id="4l4G_5dNMUG4R9APQuUXeg" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" formula="Rd_uAREh6Um6O9H8ApQsTg" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="GzuFpuP6i0eAF62qpH6KOg" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="kh-TnV7vu0CFvdVtOBmUHg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="aHizf-V4A0WOdq_3AH_24Q" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="xwne0afwe0OLzyXL5r6mUQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="5GSRcjHo7k2f_fgiD_3_FA" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" formula="N6U4wEL3dUCoixjijWyb3A" dim="Dimensionless" quantityType="0" />
-                <Parameter id="TJgZ-p5t_U-eV7HC7bEWAg" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="fW1XzkcoSkicg_WvTMPKNQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="_cvW8GwQAkGZ3xmhV6gaLw" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="f0wzRYvcRE2Mi3eyZY6-SQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="c3afAv6HckSH7698TxlFnQ" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="YBQiKoTppUGsvOFqLadqLQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="0LnKkMFafEuycqPWCGrpiQ" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="RNOp2cTxWU-p2gW3XiQzNw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="COd4rkR59UiHvYc36vLkEw" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="F2QSICUGhU-8AFPBROPG-g" dim="Dimensionless" quantityType="0" />
-                <Parameter id="wI1Gvd2Y_ka8RkN5fYy33g" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="dwVcYKulK0u-wPWqwTif3A" dim="Dimensionless" quantityType="0" />
-                <Parameter id="P_YLU6ESJEiEDO3Bntrihw" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="8_3xquVMpUeuM3RB-iYPrw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="6K5N7Ipw4EOXmY6C-FzlYA" name="Microsomal protein mass/g tissue" description="Microsomal protein content per gram tissue" persistable="0" isFixedValue="0" formula="JF0HniIEdESssuJYBOLqeQ" dim="MassProteinPerTissue" quantityType="0" />
-                <Parameter id="gTKcvJ5J10KfR86qTsd6Fw" name="Number of cells/g tissue" description="Number of cells per gram tissue" persistable="0" isFixedValue="0" formula="wvQCcGYbEEaoUZzaW1zEew" dim="CellQuantityPerTissue" quantityType="0" />
-                <Parameter id="mhIMUQmZ8EiEFG4gg3n9SA" name="Protein mass/g tissue" description="Total protein content per gram tissue" persistable="0" isFixedValue="0" formula="iiejM3tseEWEtN5Vp0ko1Q" dim="MassProteinPerTissue" quantityType="0" />
-                <Parameter id="HTOnBrzR5Ea5YHXQQAaJEQ" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="0W8io0lo1EeqCypbZMxQPg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="-z4oJmuLhkmz1ssGN9BkBA" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="NCBSRmtuzk2oXdc5JAIV4A" dim="Dimensionless" quantityType="0" />
-                <Parameter id="aHju74TBr0G4jYUspOW4ZA" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="fehkXO2tf0CCzLFlMxnvHA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="ef8IHMEfbUaSu9PzHCYhYw" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="zeUdG_HgiEOpRetCnCPw3w" dim="Dimensionless" quantityType="0" />
-                <Parameter id="YufV80dw_EG-D-WNCt_s2w" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="V9qQtANNZUyoXc3u3tGObg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="-BjNNc6G70u91EHjV7Fmbg" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="E4dpi9ZJI0GqAFq5ayx9pw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="XJV5mHNm1U6kPg316WxpTw" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="YUYIN-EF7EWwXMtUCYoiRg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="XM9NP2pFjUiQvlZbeE_5_A" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="tAAMQgmmvEWT3zA9mnzCxA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="n1xlwVHOgEeAZDOf4N1tTg" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="Oky576lcIUWs4ZXac2gX8A" dim="Dimensionless" quantityType="0" />
-                <Parameter id="ycJxiImBa0WmpCNFwydJKw" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="RXtEqVg5x06IpKmrfW1y1Q" dim="Dimensionless" quantityType="0" />
-                <DistributedParameter id="l8MXHmc6J0qoF3_gyHv6IA" name="Volume fraction water scale factor" description="Volume fraction proteins scalefactor" persistable="1" isFixedValue="0" formula="gNl_ntvUU063BWLR-Emsqg" dim="Dimensionless" quantityType="0" mode="Logical">
-                  <Children>
-                    <Parameter id="b60GWoFPMUSM9qCCKMW4Og" name="Percentile" persistable="0" isFixedValue="0" formula="xVlkuslR6E-NO-AVuOntfA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="kMuHuCXNb0SFJVy6zhklYQ" name="Mean" persistable="0" isFixedValue="0" formula="i9ehc4E5wEqPwD7KpVERPw" dim="Dimensionless" quantityType="0" />
-                  </Children>
-                </DistributedParameter>
-                <DistributedParameter id="4NbFCH9rJE2TRud1DiIDDw" name="Volume fraction proteins scale factor" description="Volume fraction proteins scalefactor" persistable="1" isFixedValue="0" formula="5OA_dSLOh0iXXwvHQWF7JA" dim="Dimensionless" quantityType="0" mode="Logical">
-                  <Children>
-                    <Parameter id="fKgXYUzPCUGNECz9wDNdUw" name="Percentile" persistable="0" isFixedValue="0" formula="AIc4C1gg4k2i3TDrT_7L0g" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="5Yyu6hHdyEyZFsVy6POO2Q" name="Mean" persistable="0" isFixedValue="0" formula="oeWaOr19FEiWhxjkk2txSA" dim="Dimensionless" quantityType="0" />
-                  </Children>
-                </DistributedParameter>
-                <DistributedParameter id="AARMsWM_Dkuoj6f56y7GEg" name="Volume fraction lipids scale factor" description="Volume fraction lipids scalefactor" persistable="1" isFixedValue="0" formula="nczXV44DL0WKq_LFtcuyQA" dim="Dimensionless" quantityType="0" mode="Logical">
-                  <Children>
-                    <Parameter id="iTBQY-Iw_UqXH09JG-82Dg" name="Percentile" persistable="0" isFixedValue="0" formula="pyemqnp4dUWCy8XT2UwP0w" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="UY3QRAWb4Um2sJB1mEv47A" name="Mean" persistable="0" isFixedValue="0" formula="eHqxcc1AOk2p9GORyN5qhw" dim="Dimensionless" quantityType="0" />
-                  </Children>
-                </DistributedParameter>
-                <DistributedParameter id="5X5E2digwEyAtHpUq15s6w" name="Volume" description="Volume of organ or compartment" persistable="1" isFixedValue="0" formula="VxfBESTXMkq-akxZkhdGZA" dim="Volume" quantityType="0" mode="Logical">
-                  <Children>
-                    <Parameter id="JgRKIr4Vq0GR7TR3omOziw" name="Percentile" persistable="0" isFixedValue="0" formula="3YPFHHqElEiB3DD92JW3TA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="MQEfrSnun0qbRE13uFsuPw" name="Mean" persistable="0" isFixedValue="0" formula="rBFa58cb8k-T_Y7vBGnJ5A" dim="Volume" quantityType="0" />
-                    <Parameter id="9w0BS3XSYEeZ5jazaE6xMw" name="GeometricDeviation" description="Geometric standard deviation of LogNormal distribution" persistable="0" isFixedValue="0" formula="Muagk21mC0C39TJR3Q2Olg" dim="Dimensionless" quantityType="0" />
-                  </Children>
-                </DistributedParameter>
-                <DistributedParameter id="iE2KQgHDBUmScyWluVcpWA" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="1" isFixedValue="0" formula="EueU5gXZNkCeZlYbFLzPtA" dim="Dimensionless" quantityType="0" mode="Logical">
-                  <Children>
-                    <Parameter id="ycy0RXROnESFQdLpNt4ehQ" name="Percentile" persistable="0" isFixedValue="0" formula="hbPF_Bkaw0uzmu-_rpWp0w" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="9IVDVvZzREq-cL0aw3DnYg" name="Mean" persistable="0" isFixedValue="0" formula="TzgOccKxaE2L_LBwroDosA" dim="Dimensionless" quantityType="0" />
-                  </Children>
-                </DistributedParameter>
-                <DistributedParameter id="0Ex0TTpdhEifHeOBeUH2lQ" name="Specific blood flow rate" description="Blood flow rate normalized to the organ volume" persistable="1" isFixedValue="0" formula="2PSgIWszQ02d2Fm-y41Xbg" dim="Flow (volume) per organ weight" quantityType="0" mode="Logical">
-                  <Children>
-                    <Parameter id="OxhfU2pn2kOu_Bqzt9Iq4g" name="Percentile" persistable="0" isFixedValue="0" formula="O9si4MkGQUW1E-gEGYJikQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="QIAGIyHW_0i47zUKwyBj2A" name="Mean" persistable="0" isFixedValue="0" formula="rwoxiJAIkkOkyz_uiZDlEg" dim="Flow (volume) per organ weight" quantityType="0" />
-                    <Parameter id="-osABaDRC0SuA1qMCPXK3A" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" formula="5kk_beSFGka8WIz9hP_R0Q" dim="Flow (volume) per organ weight" quantityType="0" />
-                  </Children>
-                </DistributedParameter>
-                <Container id="GC636Tx7uE61b65qVROxZA" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Plasma" />
-                    <Tag value="Muscle" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="y4m-636rT0eknQBDJkIYSw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                    <Parameter id="qQiU2jI4tE-MmRmj9DF7Sw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" dim="Volume" quantityType="0" />
-                    <Container id="IU70aL6Bn0OGoosE5Dzh_A" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Tags>
-                        <Tag value="MoleculeProperties" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="vSqMhSPNWkO99iSlA0eIKA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" dim="Dimensionless" quantityType="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="eK9VyfeChkylRBoB9HqkvQ" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="BloodCells" />
-                    <Tag value="Muscle" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="yC7_VeuPU0aYV3sMMR_K4w" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                    <Parameter id="4Uuu5ByKNUeaQLEgej87IQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" dim="Volume" quantityType="0" />
-                    <Container id="BiUXZGV3q0OvDhsNdpB_gg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Tags>
-                        <Tag value="MoleculeProperties" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="OXgXsTwIXkuEIk2h6-o9Sw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" dim="Dimensionless" quantityType="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="JaBSUUCDD06oopTalTFBLA" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Interstitial" />
-                    <Tag value="Muscle" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="wqqWeHul9kC9TuJ3PBXkOA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                    <Parameter id="luWJYeBRXU2izAdiNgJA1w" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" dim="Volume" quantityType="0" />
-                    <Parameter id="SzwWFenPbEyda_Mr9mjbAQ" name="pH" description="pH" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_pH_INT" dim="Dimensionless" quantityType="0" />
-                    <Container id="j7KyvgWKikaTtijkUcEqOg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Tags>
-                        <Tag value="MoleculeProperties" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="u_WI0ARDCUuKIVh4up7X6w" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_mus" dim="Dimensionless" quantityType="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="80SRRXbsyUWeN3fS1NqrUA" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Intracellular" />
-                    <Tag value="Muscle" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="xf_VU-SdL0KdFaZCZFd1wg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" dim="Volume" quantityType="0" />
-                    <Parameter id="YTipZ5St00abqdXk3OqJ5g" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" dim="Volume" quantityType="0" />
-                    <Parameter id="Tex3VAJ0nUa_G6SDty5k4w" name="pH" description="pH" persistable="0" isFixedValue="0" formula="4I0fXSAnI0yFMeNvG79q6Q" dim="Dimensionless" quantityType="0" />
-                    <Container id="6MavtFIkK0iKixGgEtYHDA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Tags>
-                        <Tag value="MoleculeProperties" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="zQJrssOsl0qIw_vX8CSbuw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_mus" dim="Dimensionless" quantityType="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-              </Children>
-            </Container>
-            <Container id="NtrF-Tdha0e6Wbrc43o9EQ" name="Pancreas" description="Pancreas" icon="Pancreas" mode="Logical" containerType="Organ">
-              <Tags>
-                <Tag value="Pancreas" />
-                <Tag value="Portal Vein Supplying Organ" />
-                <Tag value="TissueOrgan" />
-              </Tags>
-              <Children>
-                <Parameter id="9sAiJI4ZM0iuOEugEUrSLg" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" formula="VascularEndoVolume.VOLUME_VascularEndo_pan" dim="Volume" quantityType="0" />
-                <Parameter id="xiOGANAuYE6JQCelj3nm-w" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_f_cell" dim="Dimensionless" quantityType="0" />
-                <Parameter id="660_P9FQY02pIJ9XPXBYkg" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_Q_from_Qspec" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="FwxnjfMBBU6Rt19uNXmH9A" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" persistable="0" isFixedValue="0" formula="yBpVOeE3a0SVMj0HEJX2og" dim="Dimensionless" quantityType="0" />
-                <Parameter id="4rFzknsCcEeRQNh1D5CTcQ" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" formula="9wd-Ox2wP0SrxO-ygFPm8Q" dim="Density" quantityType="0" />
-                <Parameter id="xZ1Lt5hyokmSHHureLjiEQ" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" formula="AiARUSECH0W09VebLLKNCQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="oahNbNuy7U-8SugKETAMhg" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" formula="2xrBxHcsCkS0TszXYkne3g" dim="HydraulicConductivity" quantityType="0" />
-                <Parameter id="FYEiZwZTeEeS7cuNeb43UA" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" formula="Yi5QgbSsw0maxp64ym3cqw" dim="Nanolength" quantityType="0" />
-                <Parameter id="-DDUlBYjuEiLHTNSoh2aFA" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" formula="TAXGnoeAK0Gh9T9Tk0-f1A" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="kHU3GIvF40-nu7eUnhq-Lg" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" formula="v4Tn5TYkx0ijPGpn91X0_w" dim="Dimensionless" quantityType="0" />
-                <Parameter id="MvATOrEuWUeIYVstYFFVHg" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" formula="vmjKCRoESkmyp22dHiNkrg" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="eSt_SJAkbkmcchgrIeG48Q" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" formula="8WmjT1uTkUuuIo-akyiKgw" dim="Nanolength" quantityType="0" />
-                <Parameter id="gDWq51GLxU6M0F0xyyiqCQ" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="TnkZuhKgxk2BpPS8CcwkqA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="3nUgBlFP_EetVK2Y6mBt9Q" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="1JvmrCWMQUSGQF_gMjx35g" dim="Dimensionless" quantityType="0" />
-                <Parameter id="BHyur7uP6kiNAa2UFuAi_Q" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" formula="nwW2si5mbEmLLjA5dBcTzw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="DmdZAezyk02DRVYa119PQg" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="Yyj22lRnQESHD9VNwryitg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="gSV10uPxP0qBKz2oEnF4Kg" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="4WnMH0GUJU-ed3X6JbxQUQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="REtJsA9XNkGLR5ugBb9HuQ" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="t4YWqp__bEGNU-jYrlMgSg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="1Re6pS9ujEq5BQnEGPPbbA" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="mcwqnvi0K0OEuaL78uFnlA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="hRMiHdFlR0S2F565nTBI8A" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="pvisbZDtrU2JJoNP9-AETw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="buF25oS6xEmdohI_-q8XRw" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="c0ttOz9zxEqYK7BJtz57uw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="ckwS3ty60UKrcM-HASz3_Q" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="boSeBKz22EyDuhBBIITb0g" dim="Dimensionless" quantityType="0" />
-                <Parameter id="GxueepYJR0C9ArnmV_myOQ" name="Protein mass/g tissue" description="Total protein content per gram tissue" persistable="0" isFixedValue="0" formula="S2Qr8wHZjEixxKz_IM9I6g" dim="MassProteinPerTissue" quantityType="0" />
-                <Parameter id="m5r9T6fJakW3NCRCNoMIHA" name="Number of cells/g tissue" description="Number of cells per gram tissue" persistable="0" isFixedValue="0" formula="V1loUKhxSEWkrEUxoB6UYw" dim="CellQuantityPerTissue" quantityType="0" />
-                <Parameter id="FtNv6Y9kEkaLdm1kCh9Hiw" name="Microsomal protein mass/g tissue" description="Microsomal protein content per gram tissue" persistable="0" isFixedValue="0" formula="MpKLd-aWBkSWsYl6omppWw" dim="MassProteinPerTissue" quantityType="0" />
-                <Parameter id="cIYB7_ZL_kWa9ZZ17OpRiA" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" formula="MqidiJyeTEm751csU-MZRA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="ewIAWiFfdkSq0Aa2xGu2bQ" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="Tk1P_wGdj0KhbaoaiwUtBw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="FxitnMmJNEWg54zcOdmb6w" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="DUA-yMbAAEavvU_Qar-t9g" dim="Dimensionless" quantityType="0" />
-                <Parameter id="rEKx4hKraEuUncMpz6O-vQ" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="T5p_7Wst4UqlwpJMHkIJ-Q" dim="Dimensionless" quantityType="0" />
-                <Parameter id="EJGeZEWIJEirSTFxuCD-5A" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="PKiXoA90QE6unAxafO1OqQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="MT7otvZYAU6tPMMOfGfg_Q" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="lGv6FkE5AUiTX7kxort6BA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="R5wbSdKYmUmB78LPZyFF7g" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="FuhmyuVCx0OVjbwqTareFQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="Es0g_wnrG0y7ijGVNSpqtA" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="5QeQQPA6D0ymoLxd-zCPBA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="1fsP1P456EKrnCMKMmUG8Q" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="1Cc1hToz0EWFOhQtG9E-CQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="SbnL9JCtkEO-tylcpKobMg" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="fXxfSsrK7UmP0T67eJeXGQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="kBXWh7X4_0iq2f5eB5dYMg" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="17PC8So5F06mc_Ps6Lfjng" dim="Dimensionless" quantityType="0" />
-                <DistributedParameter id="2w-wd2S_JUCb1GADGLGgow" name="Volume" description="Volume of organ or compartment" persistable="1" isFixedValue="0" formula="kvrWRA4NZk6JclA1veKceg" dim="Volume" quantityType="0" mode="Logical">
-                  <Children>
-                    <Parameter id="Qre_ONa2SUW-qmO4YNoi6A" name="Percentile" persistable="0" isFixedValue="0" formula="5fqVxs3Lb0KBjk8HZ9cicw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="0NpqImNXFUiaTDXtOV7_aQ" name="Mean" persistable="0" isFixedValue="0" formula="jw6IOSBdukCfkdodPk1d0w" dim="Volume" quantityType="0" />
-                    <Parameter id="-EHGPivXf06hVD0vvhy_GQ" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" formula="Jy2oG6BfQkSq_NcFKB06Qg" dim="Volume" quantityType="0" />
-                  </Children>
-                </DistributedParameter>
-                <DistributedParameter id="-DxXRJeRcUeazwpDbe29Uw" name="Specific blood flow rate" description="Blood flow rate normalized to the organ volume" persistable="1" isFixedValue="0" formula="Zy45tPCeWUOvaqLEwldn-g" dim="Flow (volume) per organ weight" quantityType="0" mode="Logical">
-                  <Children>
-                    <Parameter id="DNfo00ey3Um3_LUJpEge8g" name="Percentile" persistable="0" isFixedValue="0" formula="9-5zg10v7kCQErlq03I_Dw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="NMmjOnZl6keimQX9_6LxWA" name="Mean" persistable="0" isFixedValue="0" formula="jV-7SLNbeEGeRS1IWf34GA" dim="Flow (volume) per organ weight" quantityType="0" />
-                    <Parameter id="pFTj1aUgG0-3Aw0KqOS1qw" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" formula="1lWyv8rLz0-QmFG8xrv80g" dim="Flow (volume) per organ weight" quantityType="0" />
-                  </Children>
-                </DistributedParameter>
-                <Container id="qaSDqw_STUiUKqcQ2q2fbQ" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Plasma" />
-                    <Tag value="Pancreas" />
-                    <Tag value="Portal Vein Supplying Organ" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="iCFbs5M-oUmkhlTTbH3Q3A" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                    <Parameter id="jbrQt_6_3UOKIdJXJ2ALDA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" dim="Volume" quantityType="0" />
-                    <Container id="AqqS52GouUC5sxkMkburHg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Tags>
-                        <Tag value="MoleculeProperties" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="Hw1TJm1rl0Kj8kzAIwidkw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" dim="Dimensionless" quantityType="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="rqg-Om2JMU-ELUIO56tN4w" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="BloodCells" />
-                    <Tag value="Pancreas" />
-                    <Tag value="Portal Vein Supplying Organ" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="tTNtdPhlIESY1lDOaMXEqw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                    <Parameter id="YYeORJrvD0mOhu8N-dNNPQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" dim="Volume" quantityType="0" />
-                    <Container id="_RQsJ0NqJEK_xGa24B0Ryw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Tags>
-                        <Tag value="MoleculeProperties" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="kpGUuVS9KkCGiOi2cy6QRg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" dim="Dimensionless" quantityType="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="_-P7kL13fU6q9uvAPmHqGg" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Interstitial" />
-                    <Tag value="Pancreas" />
-                    <Tag value="Portal Vein Supplying Organ" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="1rztFAfGUU6dFQAmBn7ACg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                    <Parameter id="6tG8uKb3h0qXQD-gCPzjvA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" dim="Volume" quantityType="0" />
-                    <Parameter id="C39qAYL_70WOPHGaOxEmTw" name="pH" description="pH" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_pH_INT" dim="Dimensionless" quantityType="0" />
-                    <Container id="yzYPQ_GxKUalHkROXXt6NQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Tags>
-                        <Tag value="MoleculeProperties" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="6t-YjOznzE2Ybz7-Q0Nm1w" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_pan" dim="Dimensionless" quantityType="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="jIlAfjg-CUSGghK47lyr2w" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Intracellular" />
-                    <Tag value="Pancreas" />
-                    <Tag value="Portal Vein Supplying Organ" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="fJJNdpm9Ck2LH33K9fOlJA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" dim="Volume" quantityType="0" />
-                    <Parameter id="GQsNcx8gpUeESJyjBw5R1g" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" dim="Volume" quantityType="0" />
-                    <Parameter id="6hrQlu-Va0GRPk0T4c7xLQ" name="pH" description="pH" persistable="0" isFixedValue="0" formula="j3JJMvKv7UKXDM3ASF4JAA" dim="Dimensionless" quantityType="0" />
-                    <Container id="CsBqc-u14ku8tBu1qLdy5g" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Tags>
-                        <Tag value="MoleculeProperties" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="l4VL-XZca0qhzBw9-nMLTA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_pan" dim="Dimensionless" quantityType="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-              </Children>
-            </Container>
-            <Container id="xZihn0-5WEKp0AQ69YQEjQ" name="PortalVein" description="PortalVein" icon="PortalVein" mode="Logical" containerType="Organ">
-              <Tags>
-                <Tag value="PortalVein" />
-                <Tag value="BloodOrgan" />
-              </Tags>
-              <Children>
-                <Parameter id="ev7IuqxwgE6QUp1y-pjhzw" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_Q_Lymph_pve" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="i-Ng_4mZtUGJhYOLGvOfmA" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_Q_pve" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="6e_YiGh8qkqJ-Js5P8A3Bg" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" persistable="0" isFixedValue="0" formula="25QI0YBXfUGRc3d9Wi2bVw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="B5Ke3B2uCEGu5ku1Rjeeiw" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" formula="KCDzBBueM0K0OE4xU48Ybw" dim="Density" quantityType="0" />
-                <Parameter id="rDUVR9meF0CbX7PbP3_tFA" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" formula="dr-vj8NatkC9AZ_af8VaHg" dim="Dimensionless" quantityType="0" />
-                <DistributedParameter id="SzofLzy3eUqBPmIbzleCjw" name="Volume" description="Volume of organ or compartment" persistable="1" isFixedValue="0" formula="HnPvhwcPJESq5-g6jz8LIg" dim="Volume" quantityType="0" mode="Logical">
-                  <Children>
-                    <Parameter id="AsktCQehKE6daiSqcTJXrQ" name="Percentile" persistable="0" isFixedValue="0" formula="ihoGwx2RkE6q26LvAI6NzQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="xxltxebltki9XfwApMkONQ" name="Mean" persistable="0" isFixedValue="0" formula="rwpC8xvl5EGyC6ZVb8jrBg" dim="Volume" quantityType="0" />
-                    <Parameter id="cVRtexhKJUC_oi3x-g2e7g" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" formula="kTYlgbausUmSEodCVwHEQA" dim="Volume" quantityType="0" />
-                  </Children>
-                </DistributedParameter>
-                <Container id="w0IqwDHp6UGv317_8RFz7w" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Plasma" />
-                    <Tag value="BloodOrgan" />
-                    <Tag value="PortalVein" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="LpC1r9I8XE-nXilTCu4kPw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                    <Parameter id="6CvQrzBRj0KlcVUpFAZabg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_pls_BloodOrgan_4Comp" dim="Volume" quantityType="0" />
-                    <Container id="tGBEY0XnkEGy57rZqD4dJg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Tags>
-                        <Tag value="MoleculeProperties" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="DwXYnWAvHUOQTjVMqVoT4w" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" dim="Dimensionless" quantityType="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="f1NQXRLB-0m-az7rPFpZXw" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="BloodCells" />
-                    <Tag value="BloodOrgan" />
-                    <Tag value="PortalVein" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="_KMRUKJ7C0CLD-aA-pgM0w" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                    <Parameter id="lWLz-VqF70yC1kuFfSq-gg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_bc_blood_organ_4comp" dim="Volume" quantityType="0" />
-                    <Container id="vsMEyEpyX0KWuVKe31_UGQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Tags>
-                        <Tag value="MoleculeProperties" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="xcBiy_RaEkmP3bW-YIK0tw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" dim="Dimensionless" quantityType="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-              </Children>
-            </Container>
-            <Container id="ZYwtU15nX0Ohw0YpCq5ELQ" name="Skin" description="Skin" icon="Skin" mode="Logical" containerType="Organ">
-              <Tags>
-                <Tag value="Skin" />
-                <Tag value="TissueOrgan" />
-              </Tags>
-              <Children>
-                <Parameter id="HOufIYT79EqrN8qyrHYSIQ" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" formula="VascularEndoVolume.VOLUME_VascularEndo_skn" dim="Volume" quantityType="0" />
-                <Parameter id="4XmagrA3HU-zizThbazyDA" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_f_cell" dim="Dimensionless" quantityType="0" />
-                <Parameter id="dKDg1OiYzEi1VcMJUXDMmA" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_Q_from_Qspec" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="VGmmBlDS1U2etaimyHwurA" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" persistable="0" isFixedValue="0" formula="lJ4AVAbQrU2uRE1LG85A6Q" dim="Dimensionless" quantityType="0" />
-                <Parameter id="hCt-SSRqcECEfD6UF57i9g" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" formula="kfEdq8Eyx0-sluB5imWJZw" dim="Density" quantityType="0" />
-                <Parameter id="Jx9Ie8XqCU6sx6vmuj4J7g" name="Peripheral blood flow fraction" description="Blood flow fraction in organ used for calculation of peripheral venous blood concentrations" persistable="0" isFixedValue="0" formula="p22FiBec0U-Vtaza-9KxBw" dim="Fraction" quantityType="0" />
-                <Parameter id="3o9X-Q8Lqkq3wX3d1m9G1Q" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" formula="5hflLyEIg0OPnbHv_xOfpg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="VqRlOfWZZUOygOuD4GIn3Q" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" formula="oDbnUQeCHkuXlTfiHcTGeA" dim="Nanolength" quantityType="0" />
-                <Parameter id="_Ed4mL5AGEulNgwAztVwrQ" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" formula="2dRqTxNDbEy_yJvnSHr9Hg" dim="Nanolength" quantityType="0" />
-                <Parameter id="0UiVvDDfEk-LQzJsd98Lcw" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" formula="OeOT8JBKUUi0_gQ0PH6lKA" dim="HydraulicConductivity" quantityType="0" />
-                <Parameter id="Ooo8ASB6n0uKGbrvxTU_bQ" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" formula="GsNz0pPV506ImD3IKD_gng" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="x8V-j8HacUWUbLIIc9hdjA" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" formula="zU7H_YSExUGRK0aP-z2AwA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="Y4G8fhdeBkyhSicnBHOIgA" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" formula="5Qn7YGT3FUSdYM36-ytCrA" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="TwhcOzlZik6AbapI5rk5Iw" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="dmzUK-p5r0OPjiqdKNQNWA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="fp67MGd9pU26pRHltMhxsQ" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="zp2GngmDLEKJ38yHCUdm0g" dim="Dimensionless" quantityType="0" />
-                <Parameter id="VI_iZKuhJUyNFweYxlaabg" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" formula="BD69toyH-kWCRsbVYpJHKg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="p57zOp0YsEmfPPQwaZN0UQ" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="KWQit-L5EECTVm1DYRMQTw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="96eHbV0zyEW9Ss9cwiQtKQ" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="sNsMxEg2vkWPD2d9K7B8xw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="mbCkMuzFqUKVoH2XfzaqmQ" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="DNuuyhYetUm4vCT-rZ632g" dim="Dimensionless" quantityType="0" />
-                <Parameter id="XLz2HOkROE-lDebCFJqN8g" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="-w-Asvh2YUmvOMt8Jh4Csw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="di2YkhjHD0-jGFuTCV67fA" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="bllPImYzLk6JKxzuroqsfg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="ALuyBQaSTEqnlzsP9O1qkg" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="1f0I_Lt-YUWcQfEyK1qrxg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="gf1Y_ZbS00i7Y4gzcPSROA" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="mA3Kq1dr_U-EKQ-aPRv5Wg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="cNcs97cmUEuDs0vzP1aCkQ" name="Protein mass/g tissue" description="Total protein content per gram tissue" persistable="0" isFixedValue="0" formula="ZfRpqvWNy0az9ng62Ftlcw" dim="MassProteinPerTissue" quantityType="0" />
-                <Parameter id="7nThDHgSnEWi2iBSfYgiHw" name="Number of cells/g tissue" description="Number of cells per gram tissue" persistable="0" isFixedValue="0" formula="KYfwgd7c1UyT86myL07haQ" dim="CellQuantityPerTissue" quantityType="0" />
-                <Parameter id="bPD6HeNzI0KQPJSFfQ_ofg" name="Microsomal protein mass/g tissue" description="Microsomal protein content per gram tissue" persistable="0" isFixedValue="0" formula="KhhR91BNyEqjrSCaDT1VNg" dim="MassProteinPerTissue" quantityType="0" />
-                <Parameter id="ytoYAYEJPUieo-te_crsiw" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" formula="CwpH7XMUC0OvblNMbmoulA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="SZZLIkOBh0qLYAnLn-OLug" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="_Y91QOTgKE2OsJYGKrsMpg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="nI9boBS9H0-qDP2dfdD55Q" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="c6PxzyYh1EeQNfmBz6eAPg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="U2EsSq-_fEGeHiTNNDG9Mg" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="JspNfSqAxEuUJo9afPpL1w" dim="Dimensionless" quantityType="0" />
-                <Parameter id="01oueuhIC0GSIF0pEPczYA" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="FCKUjDJuJ0KYYj5zPKx2ow" dim="Dimensionless" quantityType="0" />
-                <Parameter id="qH14siE73Uey8rokVQn-VA" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="JjvL6FGpcUG06MM0S1zfsg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="LAHekcU2n0WTKMLQc4nDKw" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="uG490qLiTkW9KuT_DQbtWQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="y5yhREEr1EagPCRigixuxQ" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="DMyplZLDRkWY80TCbyWPWg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="qUEvHY7u80eaLdr0JSXlFg" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="5j1Ehs5tKUegnhYSDuBVew" dim="Dimensionless" quantityType="0" />
-                <Parameter id="nHrFzU8MUUiZIQKCPI47vA" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="eYlWtXsJmE6_MZedeExOZg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="lqFR0AE_R0-3F6nk0m8I4w" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="QOSyDAGYhkC_Fgh_t7mrTw" dim="Dimensionless" quantityType="0" />
-                <DistributedParameter id="Gp1ohHeY8U-Ha3XZZogTNA" name="Volume" description="Volume of organ or compartment" persistable="1" isFixedValue="0" formula="bHd62u4Mr0eEmX9YkjHOOw" dim="Volume" quantityType="0" mode="Logical">
-                  <Children>
-                    <Parameter id="01fGs_OTfEGTW3PkkUBcGQ" name="Percentile" persistable="0" isFixedValue="0" formula="pHebrXpt60-nOsq4h0crFQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="i_kEqCVgVk2HvBAepzNyaw" name="Mean" persistable="0" isFixedValue="0" formula="d05g02mFoEmeDlNtpFCg5g" dim="Volume" quantityType="0" />
-                    <Parameter id="38oP3rh1vEy83XA9YZW7Vg" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" formula="Jy2qAgi6V0mFaXZfA81wIw" dim="Volume" quantityType="0" />
-                  </Children>
-                </DistributedParameter>
-                <DistributedParameter id="trchJKoZcUqIGeN0JNhvvg" name="Specific blood flow rate" description="Blood flow rate normalized to the organ volume" persistable="1" isFixedValue="0" formula="6tz2UCwNkUqsnb7-AmxhOg" dim="Flow (volume) per organ weight" quantityType="0" mode="Logical">
-                  <Children>
-                    <Parameter id="UNBI7FdqMkWR_XpJh4yYqA" name="Percentile" persistable="0" isFixedValue="0" formula="YYk0LhzDYE6HMthBlYe5Ew" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="Qqh5bXmdq0mh8EhoyOrpwA" name="Mean" persistable="0" isFixedValue="0" formula="6r0IsvrEQUGj5mI7JqDwgw" dim="Flow (volume) per organ weight" quantityType="0" />
-                    <Parameter id="kKnhj6oJV02MllcXfvt-FQ" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" formula="0Nben_IYMEK0PqH9uYE77A" dim="Flow (volume) per organ weight" quantityType="0" />
-                  </Children>
-                </DistributedParameter>
-                <Container id="G6h-cYh_e0yFknyXZd5Mwg" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Plasma" />
-                    <Tag value="Skin" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="l-X9dSACMUiu5T1GgvgXOw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                    <Parameter id="9AjT1A-5hUi767R53RvGSQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" dim="Volume" quantityType="0" />
-                    <Container id="NOyXQKxVREKuEJ6ECQTMEQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Tags>
-                        <Tag value="MoleculeProperties" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="-2bHWqzixUaCE1l5JxDFqA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" dim="Dimensionless" quantityType="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="qvC9N1AfkEK8pOJosYCAXA" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="BloodCells" />
-                    <Tag value="Skin" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="4Eaf29A7VU-tJofqV20msw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                    <Parameter id="diBh-UAkg0yhozxBgLp_hQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" dim="Volume" quantityType="0" />
-                    <Container id="KZawbysOIU-qlhUnT_A5pg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Tags>
-                        <Tag value="MoleculeProperties" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="hhoWe8AcPUycGHnN8ILFwA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" dim="Dimensionless" quantityType="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="Kn-rrzRbwk2lP_Bz0Q8xBw" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Interstitial" />
-                    <Tag value="Skin" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="CrRiEJfCPUCtXsstC7RdOw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                    <Parameter id="42pGEx0gZkyrkaWHuslM6g" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" dim="Volume" quantityType="0" />
-                    <Parameter id="XQj926ntkk2F8gplGL63nQ" name="pH" description="pH" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_pH_INT" dim="Dimensionless" quantityType="0" />
-                    <Container id="ZB_eLk5SrkCMZ66pk8KJSw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Tags>
-                        <Tag value="MoleculeProperties" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="NLTy0vvZVEmpLgLnU6yybw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_skn" dim="Dimensionless" quantityType="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="3hWpFFMIdUONNmNyctMGVQ" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Intracellular" />
-                    <Tag value="Skin" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="Q-qC4Z0MbkWZgk0BtZknsA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" dim="Volume" quantityType="0" />
-                    <Parameter id="vdzGWvqiN0-eq1ETQmzZbw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" dim="Volume" quantityType="0" />
-                    <Parameter id="8t5SDww2wkSAwfIRddiGQw" name="pH" description="pH" persistable="0" isFixedValue="0" formula="VgMYPgLlcUCl20m5-A5I-Q" dim="Dimensionless" quantityType="0" />
-                    <Container id="BGuFYHe7IUO4xM-0rbTUDA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Tags>
-                        <Tag value="MoleculeProperties" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="ay1HnYyS2kakHvW3nkzIZQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_skn" dim="Dimensionless" quantityType="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-              </Children>
-            </Container>
-            <Container id="Drz_Z3pAKEifC0LfqdGNYA" name="Spleen" description="Spleen" icon="Spleen" mode="Logical" containerType="Organ">
-              <Tags>
-                <Tag value="Spleen" />
-                <Tag value="Portal Vein Supplying Organ" />
-                <Tag value="TissueOrgan" />
-              </Tags>
-              <Children>
-                <Parameter id="ynCmU9NhdEuey1rZLhBxKg" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" formula="VascularEndoVolume.VOLUME_VascularEndo_spl" dim="Volume" quantityType="0" />
-                <Parameter id="3GOz3RJs_kCWWd4CeDw_Uw" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_f_cell" dim="Dimensionless" quantityType="0" />
-                <Parameter id="oTdnM0rpo0K7qjEYeBBwbA" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_Q_from_Qspec" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="GmHzEJ2scEGdT_to_FC4Dw" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" persistable="0" isFixedValue="0" formula="3IaDrfyvpE-ZDGbCVMZFbQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="bLrqDihYSU2IJWcBJ2eq2A" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" formula="5VD3kF6At0yMjwAlFcAM8Q" dim="Density" quantityType="0" />
-                <Parameter id="CPxkLoJtOEW6zAnIALZ91w" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" formula="xkkI3nvrc0uWlLcmGfMOaw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="BI2r-o076USNCGCw7uF0ow" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" formula="ZORF4zNXM0WgJll4JZb7vQ" dim="Nanolength" quantityType="0" />
-                <Parameter id="LK_Q0xJWO0-wIkAUbqbEzw" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" formula="TwvFGoxk706Hdwce7F7aVg" dim="Nanolength" quantityType="0" />
-                <Parameter id="0L64DPwJnUyp9Leq7TuP3A" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" formula="rLt4Sz4p0EKuS7plwFYM4g" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="kcddQFGE_0eoLKGzswz1pQ" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" formula="bsKAEQBngU-Gxqe6vO_QWg" dim="HydraulicConductivity" quantityType="0" />
-                <Parameter id="0Y3h5A391ESx_itJ7gdwqg" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" formula="aOaHXu7bM02Mi1gwvAzpoA" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="gImGsWP5f0ulgtwgkwjvSQ" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" formula="D2SHe18W5U2lTlN0uNJWhw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="NDtNyRiCo0-NB-z_J6gAeQ" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="gHMNXeZsiU6xphTkMcRdtA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="IOAjalZKgUuWX_sxEVH0KA" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="naW9zRGxvkCqjie61D_Cmw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="DfmJwM6_iEu0DxZxXHzUJw" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" formula="k4ph8LgyEUGzdpo6mtui_w" dim="Dimensionless" quantityType="0" />
-                <Parameter id="_IrE8mGzIkmLCCWZtH7hww" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="5Gj5tPmY-UuK6vEoOVlr7w" dim="Dimensionless" quantityType="0" />
-                <Parameter id="ZCY38PZGcEmSUPzpQmdUMg" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="d1yeA7UaPkO2J7XnGwBJXw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="e0C2ZZWNak-8Qp6oaDJHAQ" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="iDFZMculjUWN4DsBSbO-kg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="prtxvvpfGUGwUmvW5ylzEg" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="TbMxZgDEwkeXm4Pca6bF5w" dim="Dimensionless" quantityType="0" />
-                <Parameter id="_TuHivL7sUSZiuVSkSzCLw" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="9G8fwoTg0kOXtRjc3bFFYQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="zcKprj27fUKYyrOOJgHMoQ" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="MqXV5l0Q90SyAFIQJwJ7UA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="K28OvyPp1E6bdXtvucv46g" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="qMHDQYzzDk6KjUykcVjzPg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="xrUTpvxJbE2rsWSckMzJXQ" name="Protein mass/g tissue" description="Total protein content per gram tissue" persistable="0" isFixedValue="0" formula="IU_3gD_sqUqSypgck5M51A" dim="MassProteinPerTissue" quantityType="0" />
-                <Parameter id="uPGAiJj4W0qFoKC90P6-ag" name="Number of cells/g tissue" description="Number of cells per gram tissue" persistable="0" isFixedValue="0" formula="6SWwVVdf-0iO7JXE0RwUjQ" dim="CellQuantityPerTissue" quantityType="0" />
-                <Parameter id="n_wENjteLUSWUc45YbtrOA" name="Microsomal protein mass/g tissue" description="Microsomal protein content per gram tissue" persistable="0" isFixedValue="0" formula="BdTjHMZgXkqzYf_RPd8jAA" dim="MassProteinPerTissue" quantityType="0" />
-                <Parameter id="2hkkvqGiNE2QRmmP5zCo3g" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" formula="veNR-rXqgUqQU4AaWw8xuw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="vxoeWzpdIU2atxj6AiZpeA" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="W7YtkbYVc0q3rBDWCmvvAQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="55GmATZqo0ajEmMCDDyOoQ" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="CDFmYTujkEy1rLZl25A8Vw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="JSxPP6XAikKq_6D5oLVtgw" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="qtZ_itzV1kOSgUWzy4QwTQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="BxFL1q-A6UOF3SFPOmqInQ" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="E_bMjkmhGESEJ9wov00WNQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="BAhOGjStOkqyXiK-1RiPkA" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="3MSRmRjAckSZ7s0elPlEIA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="L28mpmr0zEGTsTpv6mx_1g" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="n8D7z0qEi0iiyeg_oCwBHg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="lOI_wYW4cE-5mer0YIAayw" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="5q0_5uEJfEu92TjQGKS4vw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="nQvtaR6lvEOD749yCo-4Ug" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="rncxfHdNYkm-R26bNnqd5Q" dim="Dimensionless" quantityType="0" />
-                <Parameter id="ksknaDTWY0CKW_EBFcVzOg" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="pD_gArmW7Ea-uhouXA8nEg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="8nh-7w94X0WIufxylfp2kw" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="iunfmmpZtU61t_9YPkSnBQ" dim="Dimensionless" quantityType="0" />
-                <DistributedParameter id="C-V8nsiI1EehS2bli0LHxw" name="Volume" description="Volume of organ or compartment" persistable="1" isFixedValue="0" formula="VeNpPaX2SkWoXYrnw1PN7g" dim="Volume" quantityType="0" mode="Logical">
-                  <Children>
-                    <Parameter id="-Vy5Bzc5NUqQLJU1gXc2IQ" name="Percentile" persistable="0" isFixedValue="0" formula="1vT-dvgmokeBiTRnU85bqQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="nEg0QO6NikaGcU-xk_mGsw" name="Mean" persistable="0" isFixedValue="0" formula="MuVlLvme0EG3p1Kn_qVXFg" dim="Volume" quantityType="0" />
-                    <Parameter id="O0vCWDWZ7U-X5Hu8AAm5_g" name="GeometricDeviation" description="Geometric standard deviation of LogNormal distribution" persistable="0" isFixedValue="0" formula="1IHK-1q4jUi-Xvl4yH9A4A" dim="Dimensionless" quantityType="0" />
-                  </Children>
-                </DistributedParameter>
-                <DistributedParameter id="cu1hVLKUxUuLxjJbHHZVRg" name="Specific blood flow rate" description="Blood flow rate normalized to the organ volume" persistable="1" isFixedValue="0" formula="1r56RzYwLEekxPC8MVDhzA" dim="Flow (volume) per organ weight" quantityType="0" mode="Logical">
-                  <Children>
-                    <Parameter id="Y8uR2m4-3U-TDQ3B-_5JQg" name="Percentile" persistable="0" isFixedValue="0" formula="GNUAR9KQy02ryS9SjMj73g" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="wgnHx1Q9GUOrlElzH2cgNw" name="Mean" persistable="0" isFixedValue="0" formula="HTHz0jnPaUyDpviLdbpX1w" dim="Flow (volume) per organ weight" quantityType="0" />
-                    <Parameter id="IEEMZjIjDEy98NMH9EtU1Q" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" formula="C_bWD-E6iUmT-kg8XEsISQ" dim="Flow (volume) per organ weight" quantityType="0" />
-                  </Children>
-                </DistributedParameter>
-                <Container id="rc0YARtG-Eunbt8MATEJfw" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Plasma" />
-                    <Tag value="Portal Vein Supplying Organ" />
-                    <Tag value="Spleen" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="A2FHr9m470-RqGOTxwtaYQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                    <Parameter id="e7xVS7qzLEe1Xo7L0tLUyA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" dim="Volume" quantityType="0" />
-                    <Container id="uJ-gpgapg0ODw4PCBmlqlQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Tags>
-                        <Tag value="MoleculeProperties" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="yDPRuICF6UeETIw26G3D-Q" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_PLS" dim="Dimensionless" quantityType="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="kHaRuNvhZU2sFR-n9sC5oQ" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="BloodCells" />
-                    <Tag value="Portal Vein Supplying Organ" />
-                    <Tag value="Spleen" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="OILbl1ljEUOQa0wC11kAMA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                    <Parameter id="qW-6SK85s0GeDh5NjHaTFw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_bc_4Comp" dim="Volume" quantityType="0" />
-                    <Container id="KZ95DaTWQUeXhU9316-PhQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Tags>
-                        <Tag value="MoleculeProperties" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="ane4XkZCRUa5zOf0OJUHoA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_BC" dim="Dimensionless" quantityType="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="wBcGoQrNPkmc-L9H-rAxeQ" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Interstitial" />
-                    <Tag value="Portal Vein Supplying Organ" />
-                    <Tag value="Spleen" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="TH1FfqF-xECWW0QJQX_TYQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Compartment" dim="Volume" quantityType="0" />
-                    <Parameter id="am2HC5TXj0mmtrRdzUkTmQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_int_4Comp" dim="Volume" quantityType="0" />
-                    <Parameter id="TloXPfL5XEaJcvcGX1LnOA" name="pH" description="pH" persistable="0" isFixedValue="0" formula="Individual_PKSim.PARAM_pH_INT" dim="Dimensionless" quantityType="0" />
-                    <Container id="lxNsdewSjEqSk80r6rMsnA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Tags>
-                        <Tag value="MoleculeProperties" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="eYKbPM2uYUWgnu5cc0EcXQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_INT_spl" dim="Dimensionless" quantityType="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="WWc5qJwmekWeZ-35762U1Q" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Intracellular" />
-                    <Tag value="Portal Vein Supplying Organ" />
-                    <Tag value="Spleen" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="KY0caKYddUib1HSqJ-BbQQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="CompoundCommon.PARAM_ProteinContainerVolume_Organ" dim="Volume" quantityType="0" />
-                    <Parameter id="Y5wslFieZkOpGxnZfW6C5w" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_cell_4Comp" dim="Volume" quantityType="0" />
-                    <Parameter id="ghzxgduigU6cz-GIJ4mHmg" name="pH" description="pH" persistable="0" isFixedValue="0" formula="y5-Wyf_7N0mNTXP2ZADdCQ" dim="Dimensionless" quantityType="0" />
-                    <Container id="Y9FNSlATO0ufgEO3cW18Gw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Tags>
-                        <Tag value="MoleculeProperties" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="Fyw9NpBbeEqS9c93b-WRFA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_Water_CELL_spl" dim="Dimensionless" quantityType="0" />
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-              </Children>
-            </Container>
-            <Container id="Vor84zlzbU-4c2iKCcwfaQ" name="Saliva" description="Saliva: sampling compartment, not effective for total mass balance" mode="Logical" containerType="Organ">
-              <Tags>
-                <Tag value="Saliva" />
-              </Tags>
-              <Children>
-                <Parameter id="mBfLggzmgUqU_6aVrRM-Xg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="Individual_PKSim.VOLUME_Saliva_Organ" dim="Volume" quantityType="0" />
-                <Parameter id="P-cdH3VIHEqmv2a1skN8cQ" name="Saliva flow rate" description="Saliva flow rate" persistable="0" isFixedValue="0" formula="Ckb6tSGTnEy_VsKM_VP_UQ" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="nix0Yyig-kqteSOftxBalA" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" formula="JCnKBUq4JkSxhIW-D0HnOw" dim="Density" quantityType="0" />
-                <Container id="_6zflDoluUqVmHs9DMUJ3w" name="Saliva" description="Saliva: sampling compartment, not effective for total mass balance" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Saliva" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="1X4lKlrnY0m9YwlGmb_lKQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_slv_slv" dim="Volume" quantityType="0" />
-                    <Parameter id="6vesjGzAn0OT_1XVlT1p_g" name="pH (saliva)" description="pH of saliva" persistable="0" isFixedValue="0" formula="QOjl3YXrtEuFVg2SNIkzmw" dim="Dimensionless" quantityType="0" />
-                    <Container id="ZdLvcuAT70GUHuysjhUYeg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Tags>
-                        <Tag value="MoleculeProperties" />
-                      </Tags>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="VIR7U2IoDUSBFGnqmfad_A" name="SalivaGland" description="Salivary Gland" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="SalivaGland" />
-                    <Tag value="Saliva" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="ggk5gc0dAk62AwB9QaeXGA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="CompartmentsVolume_4Comp.VOLUME_slv_slv" dim="Volume" quantityType="0" />
-                    <Container id="asW3wGlbI0C21f85BcXziQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
-                      <Tags>
-                        <Tag value="MoleculeProperties" />
-                      </Tags>
-                    </Container>
-                  </Children>
-                </Container>
-              </Children>
-            </Container>
-          </Children>
-        </Container>
-        <Container id="qysVn9JYWUW07_aSIm1h3Q" name="Events" description="Parent container for all non-application events" mode="Logical" containerType="Other">
-          <Tags>
-            <Tag value="Events" />
-          </Tags>
-        </Container>
-      </TopContainers>
-      <NeighborhoodsContainer id="j_2mkCgCM0qHEZQF_yW1MQ" name="Neighborhoods" description="Neighborhoods" mode="Logical" containerType="Other">
-        <Children>
-          <NeighborhoodBuilder id="OOaXhoo2pki3INNalfGLzQ" name="VenousBlood_pls_VenousBlood_bc" description="Neighborhood between Venous Blood/Plasma and Venous Blood/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="j2n6uKMQM0uCZWZ--9NUbg" secondNeighbor="td5KxHkAVkiuQetPlAwgVQ">
-            <Tags>
-              <Tag value="VenousBlood_pls_VenousBlood_bc" />
-              <Tag value="Neighborhood: Plasma / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="wNZFdQ25kUWR3PiT3exyMQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              <Parameter id="tB4csJTx4kykYAaWepq9CA" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls_Blood_Organ" dim="Surface" quantityType="0" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="lcGTDNmVEUml0OiQVoqsPg" name="VenousBlood_bc_Lung_bc" description="Neighborhood between Venous Blood/Blood Cells and Lung/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="td5KxHkAVkiuQetPlAwgVQ" secondNeighbor="8Hxc0s3ANEWMmGloh6Tvcg">
-            <Tags>
-              <Tag value="VenousBlood_bc_Lung_bc" />
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="NKcHREyU0E2zr-ts0B4gZw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="Mr_pnw3EcUGRxfYiEviIjg" name="VenousBlood_pls_Lung_pls" description="Neighborhood between Venous Blood/Plasma and Lung/Plasma" mode="Logical" containerType="Other" firstNeighbor="j2n6uKMQM0uCZWZ--9NUbg" secondNeighbor="WCwWAQPlBEiu2DPVUYG1Zg">
-            <Tags>
-              <Tag value="VenousBlood_pls_Lung_pls" />
-              <Tag value="Neighborhood: Plasma / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="_ZZoVXo8pEq-mINdpZnw7Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="fabk3GGVFUG7DXPf9uVOlw" name="ArterialBlood_pls_ArterialBlood_bc" description="Neighborhood between Arterial Blood/Plasma and Arterial Blood/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="CcmyB0FGkEKvncpso4EAvQ" secondNeighbor="Q5cCzzKlnke4qkHZ8xor5Q">
-            <Tags>
-              <Tag value="ArterialBlood_pls_ArterialBlood_bc" />
-              <Tag value="Neighborhood: Plasma / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="K_QN5iFHrkKkC1s7z6gSzQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              <Parameter id="aOosYnmpj0uvdKMn7JNyLg" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls_Blood_Organ" dim="Surface" quantityType="0" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="JvNtYW100kC7fZ-5tMjMKw" name="Bone_int_Bone_cell" description="Neighborhood between Bone/Interstitial and Bone/Intracellular" mode="Logical" containerType="Other" firstNeighbor="fVle7EGUPUCUc-_DIn6HPQ" secondNeighbor="NjEZJ1GMDEGlYTPRpeO31A">
-            <Tags>
-              <Tag value="Bone_int_Bone_cell" />
-              <Tag value="Neighborhood: Interstitial / Intracellular" />
-            </Tags>
-            <Children>
-              <Container id="MA8HxVG6BUmWU_YRhSK4nQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="GI0W_eP_SEeyvyNH47V5Ug" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" dim="Velocity" quantityType="0" />
-                  <Parameter id="SMN1O2cffk6AQ_FEAYX1sQ" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" dim="Velocity" quantityType="0" />
-                  <Parameter id="9Gq02VQ0nECXWBVvmFMwGg" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" dim="Flow (volume)" quantityType="0" />
-                  <Parameter id="MO0evd-CQEKlHmnG9nBIdw" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" dim="Flow (volume)" quantityType="0" />
-                  <Parameter id="vjZqYrjeCkWPyMSWcUXEnA" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="PDraBZR1bEGgyXD8vIiESA" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="ktqHk50x_UaCYfsDccPi_w" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="zc6ToFmhAkeW9cJ18tK8Hw" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" dim="Dimensionless" quantityType="0" />
-                </Children>
-              </Container>
-              <Parameter id="JZM9Zfz3dkqKqoWjJcQQng" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_bon" dim="Surface" quantityType="0" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="npGIDpKcR0uESGVI0l9-YQ" name="Bone_bc_VenousBlood_bc" description="Neighborhood between Bone/Blood Cells and Venous Blood/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="IdyTRgrwCk2h6V80mW3PDQ" secondNeighbor="td5KxHkAVkiuQetPlAwgVQ">
-            <Tags>
-              <Tag value="Bone_bc_VenousBlood_bc" />
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="1v-wU2QZgE2OW-PXXhd06Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="YW5DLdK5EEKrYbS8ynaOHQ" name="Bone_pls_Bone_int" description="Neighborhood between Bone/Plasma and Bone/Interstitial" mode="Logical" containerType="Other" firstNeighbor="1QX1qBETMkegE2iTSbuxZw" secondNeighbor="fVle7EGUPUCUc-_DIn6HPQ">
-            <Tags>
-              <Tag value="Bone_pls_Bone_int" />
-              <Tag value="Neighborhood: Plasma / Interstitial" />
-            </Tags>
-            <Children>
-              <Container id="W9M97LByBUmxjECqgQRV-A" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="XP2nCLLVtUeAdAcBxB_7Jw" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" formula="NLgpMQWgn0yrrZLgTEw2vA" dim="Velocity" quantityType="0" />
-                  <Parameter id="i88AnUf8eEmu-RbgcAkcjQ" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" dim="Dimensionless" quantityType="0" />
-                </Children>
-              </Container>
-              <Parameter id="hcufOxEIGECzhynN8JAeTQ" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" dim="Surface" quantityType="0" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="U2ELfEKZFUOmIF6xfUzxDw" name="Bone_pls_VenousBlood_pls" description="Neighborhood between Bone/Plasma and Venous Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="1QX1qBETMkegE2iTSbuxZw" secondNeighbor="j2n6uKMQM0uCZWZ--9NUbg">
-            <Tags>
-              <Tag value="Bone_pls_VenousBlood_pls" />
-              <Tag value="Neighborhood: Plasma / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="61fi5aaL80Cf95hOF_Ke5Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="3WGQjSr5P0Wr_zP3EMUlZA" name="Bone_pls_Bone_bc" description="Neighborhood between Bone/Plasma and Bone/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="1QX1qBETMkegE2iTSbuxZw" secondNeighbor="IdyTRgrwCk2h6V80mW3PDQ">
-            <Tags>
-              <Tag value="Bone_pls_Bone_bc" />
-              <Tag value="Neighborhood: Plasma / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="wf_CeBcWO0Oy-oEcjcTmGQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              <Parameter id="Z39yfvCAPUO2__Jb4NkszA" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" dim="Surface" quantityType="0" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="jQuP_8ckm0-ba-NqMBCuAQ" name="Brain_pls_Brain_bc" description="Neighborhood between Brain/Plasma and Brain/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="ozvB9jxtHUKYb5zIJ-i0oA" secondNeighbor="LnYylnnd70CKWWLhZ5wiiw">
-            <Tags>
-              <Tag value="Brain_pls_Brain_bc" />
-              <Tag value="Neighborhood: Plasma / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="QimAJij_mkSRscDcF3qL6Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              <Parameter id="4HTEeo9Cd02nidDndsLoGA" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" dim="Surface" quantityType="0" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="6kD0JnbWy0ecVn-3PDhQyA" name="Brain_pls_VenousBlood_pls" description="Neighborhood between Brain/Plasma and Venous Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="ozvB9jxtHUKYb5zIJ-i0oA" secondNeighbor="j2n6uKMQM0uCZWZ--9NUbg">
-            <Tags>
-              <Tag value="Brain_pls_VenousBlood_pls" />
-              <Tag value="Neighborhood: Plasma / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="ABwlyshbyk-v5shhojXlPw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="IOmSI5KIrUS6bGg2xPMIvg" name="Brain_pls_Brain_int" description="Neighborhood between Brain/Plasma and Brain/Interstitial" mode="Logical" containerType="Other" firstNeighbor="ozvB9jxtHUKYb5zIJ-i0oA" secondNeighbor="OFqosGHD3k6-j26RlBdWAg">
-            <Tags>
-              <Tag value="Brain_pls_Brain_int" />
-              <Tag value="Neighborhood: Plasma / Interstitial" />
-            </Tags>
-            <Children>
-              <Container id="eXjrnwDSDUKsa4-QNBQb4w" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="bx4Q5jyJO0iKgJXrdJ2dXg" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="J4v8259rU0uZXY6ttbxAjA" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" formula="DiffusionPlasma_PKSim.PARAM_P_endothelial_Brain" dim="Velocity" quantityType="0" />
-                </Children>
-              </Container>
-              <Parameter id="PQ_AhvqjHEqBNYRANEZdAQ" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" dim="Surface" quantityType="0" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="cwDyHL9k_EOApQiu4GWGlA" name="Brain_bc_VenousBlood_bc" description="Neighborhood between Brain/Blood Cells and Venous Blood/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="LnYylnnd70CKWWLhZ5wiiw" secondNeighbor="td5KxHkAVkiuQetPlAwgVQ">
-            <Tags>
-              <Tag value="Brain_bc_VenousBlood_bc" />
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="nIWPRSD_I02OuGkWWDObqg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="e75Q4cJSO0O-ROzcmMH_mQ" name="Brain_int_Brain_cell" description="Neighborhood between Brain/Interstitial and Brain/Intracellular" mode="Logical" containerType="Other" firstNeighbor="OFqosGHD3k6-j26RlBdWAg" secondNeighbor="KCg-1x-QxESKsTdue2PYPQ">
-            <Tags>
-              <Tag value="Brain_int_Brain_cell" />
-              <Tag value="Neighborhood: Interstitial / Intracellular" />
-            </Tags>
-            <Children>
-              <Container id="8R8OdBv0rEuYvmqtN_UOpA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="lDZP94eOSUOuQAR_VIrl4g" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" dim="Velocity" quantityType="0" />
-                  <Parameter id="MsAMNnRNXkuKqTTPfS-7GQ" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" dim="Velocity" quantityType="0" />
-                  <Parameter id="-ozZZMmLp0-Bxer7zDwFUQ" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" dim="Flow (volume)" quantityType="0" />
-                  <Parameter id="e8MBwiHanUaVzDPxJTS5Lg" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" dim="Flow (volume)" quantityType="0" />
-                  <Parameter id="uxl0Q_xN10yGye1m1x0xKQ" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="eZ_ifLbaCUaq7nUi70ASww" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="_xoETVJJg0ag4GTncutANg" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="r3UAdd6pJkGVUxnkgYpBEQ" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" dim="Dimensionless" quantityType="0" />
-                </Children>
-              </Container>
-              <Parameter id="jhk2sTiukEGA1zTy5wwuMA" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_brn" dim="Surface" quantityType="0" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="4KeU8PMkWkuqjREI4eq2bg" name="Fat_pls_Fat_bc" description="Neighborhood between Fat/Plasma and Fat/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="TB2j7eh8O0ujgR7ZSmvJyQ" secondNeighbor="_oYSlCwAvEqqYY-nr9vV-A">
-            <Tags>
-              <Tag value="Fat_pls_Fat_bc" />
-              <Tag value="Neighborhood: Plasma / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="xGz_9q7s_EmKqKxp7yU1Ag" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              <Parameter id="9DpIe1RYKEmvtiaNCrFwTA" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" dim="Surface" quantityType="0" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="9k2-SEm9c0SMphMusSMdlA" name="Fat_bc_VenousBlood_bc" description="Neighborhood between Fat/Blood Cells and Venous Blood/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="_oYSlCwAvEqqYY-nr9vV-A" secondNeighbor="td5KxHkAVkiuQetPlAwgVQ">
-            <Tags>
-              <Tag value="Fat_bc_VenousBlood_bc" />
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="5uWPjbRWhkKwXxKs99-mGg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="67ualX4XcUmoMe7Xh3GOwQ" name="Fat_int_Fat_cell" description="Neighborhood between Fat/Interstitial and Fat/Intracellular" mode="Logical" containerType="Other" firstNeighbor="M9k4PJfLME653ailMNDypA" secondNeighbor="DW5RiC3hLkOsej5WSXn9iA">
-            <Tags>
-              <Tag value="Fat_int_Fat_cell" />
-              <Tag value="Neighborhood: Interstitial / Intracellular" />
-            </Tags>
-            <Children>
-              <Container id="uCjVYmJfTEGWezfntL5ZMg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="34iIeA0BOEqUPJHKLrDUNA" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" dim="Flow (volume)" quantityType="0" />
-                  <Parameter id="69lrXROT9EWiJOEHEMUckw" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" dim="Velocity" quantityType="0" />
-                  <Parameter id="EhrgCZEoYkyulDkNkE8pBQ" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" dim="Flow (volume)" quantityType="0" />
-                  <Parameter id="PcfHrwITq0mwFCO99H_iDw" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="3FeZgSkM0Ue7IrqHZtpplQ" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="42xiMWpDR0CsAjK29hbJSg" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="EyZ2tPb4e0Onq8r06N5NpQ" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="SVk29GWMtkaNfJKgNVsK8g" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" dim="Velocity" quantityType="0" />
-                </Children>
-              </Container>
-              <Parameter id="2iEZIaFRY0CR2dzMFBzmpQ" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_fat" dim="Surface" quantityType="0" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="31-h9aonQEyBtM4k1ZR4aw" name="Fat_pls_Fat_int" description="Neighborhood between Fat/Plasma and Fat/Interstitial" mode="Logical" containerType="Other" firstNeighbor="TB2j7eh8O0ujgR7ZSmvJyQ" secondNeighbor="M9k4PJfLME653ailMNDypA">
-            <Tags>
-              <Tag value="Fat_pls_Fat_int" />
-              <Tag value="Neighborhood: Plasma / Interstitial" />
-            </Tags>
-            <Children>
-              <Container id="uLAaj9Dnlku6ysOjpyNYhw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="3urrL6zIQEGIgTNImM778g" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="Sz47EG0utkWJcWQ66jF9IQ" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" formula="MXyBiTJ8xU-TTbInqrxq7g" dim="Velocity" quantityType="0" />
-                </Children>
-              </Container>
-              <Parameter id="WZuHKRvmPUmNclPlOwYa-A" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" dim="Surface" quantityType="0" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="LbrXG9elc0C_rPE4Sr-6ig" name="Fat_pls_VenousBlood_pls" description="Neighborhood between Fat/Plasma and Venous Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="TB2j7eh8O0ujgR7ZSmvJyQ" secondNeighbor="j2n6uKMQM0uCZWZ--9NUbg">
-            <Tags>
-              <Tag value="Fat_pls_VenousBlood_pls" />
-              <Tag value="Neighborhood: Plasma / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="eBHl2e-Nr0SJmqpUEYwKNw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="WECgE5FllkivAsk5L_bPDA" name="Gonads_bc_VenousBlood_bc" description="Neighborhood between Gonads/Blood Cells and Venous Blood/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="eaIswCZLm0uzQT4GU7uRVA" secondNeighbor="td5KxHkAVkiuQetPlAwgVQ">
-            <Tags>
-              <Tag value="Gonads_bc_VenousBlood_bc" />
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="_1Hv0kYOlUWYRF89pDSVOw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="z1S4h-LWZkWROYSzRQLzvg" name="Gonads_pls_VenousBlood_pls" description="Neighborhood between Gonads/Plasma and Venous Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="P1zi7RPUsk27LJ1SfhYvgw" secondNeighbor="j2n6uKMQM0uCZWZ--9NUbg">
-            <Tags>
-              <Tag value="Gonads_pls_VenousBlood_pls" />
-              <Tag value="Neighborhood: Plasma / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="owiQKQ_cUUqFIUS-ePryrA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="rQu2pAgONUS3ILS_F-41OA" name="Gonads_int_Gonads_cell" description="Neighborhood between Gonads/Interstitial and Gonads/Intracellular" mode="Logical" containerType="Other" firstNeighbor="ewqB_sVllUqKRrHxiVkMsg" secondNeighbor="mvPEUvCjjE2amGVxx_avJA">
-            <Tags>
-              <Tag value="Gonads_int_Gonads_cell" />
-              <Tag value="Neighborhood: Interstitial / Intracellular" />
-            </Tags>
-            <Children>
-              <Container id="YEE1IknrfEiJzi29d0ywjw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="mBaOLyT13E-j_krZ8Y1oQA" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="AWL_tpbDDECaRfuJKFCeDA" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" dim="Velocity" quantityType="0" />
-                  <Parameter id="VTFBwuN-jUqJyyS-MS77UQ" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" dim="Velocity" quantityType="0" />
-                  <Parameter id="IGbu8WTBIkCcnNYrhj0Vcw" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" dim="Flow (volume)" quantityType="0" />
-                  <Parameter id="rCFlfqfBhkuOXJT3Yv7DYg" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="u4B0QkL_VESG5unufAe5lg" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="r3I1nOWMLkGPIH5IfjpgyQ" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="jgkcg4vbrkexBAJcwf02AQ" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" dim="Flow (volume)" quantityType="0" />
-                </Children>
-              </Container>
-              <Parameter id="Z5K4NDn1YUmDiybq_b1T8g" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_tes" dim="Surface" quantityType="0" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="ayNqnay74kic1VnPSSpUKA" name="Gonads_pls_Gonads_bc" description="Neighborhood between Gonads/Plasma and Gonads/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="P1zi7RPUsk27LJ1SfhYvgw" secondNeighbor="eaIswCZLm0uzQT4GU7uRVA">
-            <Tags>
-              <Tag value="Gonads_pls_Gonads_bc" />
-              <Tag value="Neighborhood: Plasma / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="78w__6rxdUiZkBwf1ytw9A" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              <Parameter id="xkELncjqFkakjGRNNqVRRA" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" dim="Surface" quantityType="0" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="OAx7hmLhk0O8zOOtNFW17A" name="Gonads_pls_Gonads_int" description="Neighborhood between Gonads/Plasma and Gonads/Interstitial" mode="Logical" containerType="Other" firstNeighbor="P1zi7RPUsk27LJ1SfhYvgw" secondNeighbor="ewqB_sVllUqKRrHxiVkMsg">
-            <Tags>
-              <Tag value="Gonads_pls_Gonads_int" />
-              <Tag value="Neighborhood: Plasma / Interstitial" />
-            </Tags>
-            <Children>
-              <Container id="tGy69ynPtEG6CjP65rSxJg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="v1R5EJMmc0OIuWxifO8L3w" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" formula="x3WstOUmi06xGEKt9XdaIA" dim="Velocity" quantityType="0" />
-                  <Parameter id="OFW5v7mBxkWCVRzxbGdi1A" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" dim="Dimensionless" quantityType="0" />
-                </Children>
-              </Container>
-              <Parameter id="w5BmIdyVj0G7SCvtVUxPrg" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" dim="Surface" quantityType="0" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="EXYYDisCpE-Sa6a2sqdCkQ" name="Heart_pls_Heart_bc" description="Neighborhood between Heart/Plasma and Heart/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="XAQdPJN_Z02jzlcPJL4q9Q" secondNeighbor="6CFlcb_lrU6luBMQ8jh8fg">
-            <Tags>
-              <Tag value="Heart_pls_Heart_bc" />
-              <Tag value="Neighborhood: Plasma / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="ALrlBuepmECftiEYm96ozA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              <Parameter id="p4NlperruU-iZcweBlN-DQ" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" dim="Surface" quantityType="0" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="zBN3cwezmEmhabml20I3uA" name="Heart_pls_VenousBlood_pls" description="Neighborhood between Heart/Plasma and Venous Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="XAQdPJN_Z02jzlcPJL4q9Q" secondNeighbor="j2n6uKMQM0uCZWZ--9NUbg">
-            <Tags>
-              <Tag value="Heart_pls_VenousBlood_pls" />
-              <Tag value="Neighborhood: Plasma / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="bE44vKSv2kKrycfXRpC7xQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="Fdx68AzwHU2L5_13BvFSxg" name="Heart_pls_Heart_int" description="Neighborhood between Heart/Plasma and Heart/Interstitial" mode="Logical" containerType="Other" firstNeighbor="XAQdPJN_Z02jzlcPJL4q9Q" secondNeighbor="I7bINaSuD0WzKUqQQL0fGw">
-            <Tags>
-              <Tag value="Heart_pls_Heart_int" />
-              <Tag value="Neighborhood: Plasma / Interstitial" />
-            </Tags>
-            <Children>
-              <Container id="tSXw5bWjGUC5rfA033wubQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="ayOTnETOu0Ckpbf-rpdRsw" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" formula="4dMoxcy670mSAo9jnxZoVQ" dim="Velocity" quantityType="0" />
-                  <Parameter id="z91OsrQIBk-mArGYk_0Dsg" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" dim="Dimensionless" quantityType="0" />
-                </Children>
-              </Container>
-              <Parameter id="SooSQzpjBUiER5GWCUicLw" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" dim="Surface" quantityType="0" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="v4XNzgSv40S0wWpIwk4MAQ" name="Heart_int_Heart_cell" description="Neighborhood between Heart/Interstitial and Heart/Intracellular" mode="Logical" containerType="Other" firstNeighbor="I7bINaSuD0WzKUqQQL0fGw" secondNeighbor="FmqZSzKh90W-2a_HA6avrw">
-            <Tags>
-              <Tag value="Heart_int_Heart_cell" />
-              <Tag value="Neighborhood: Interstitial / Intracellular" />
-            </Tags>
-            <Children>
-              <Container id="D5g7BfUgqU6IB_d3eelsNw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="Iip6xfhvpE2_V9EMhrp5pQ" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="TnzevDIDRUirZCyVujxQ1w" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" dim="Velocity" quantityType="0" />
-                  <Parameter id="uQP6lbHhqUGTerOmw9IODw" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" dim="Velocity" quantityType="0" />
-                  <Parameter id="49luCM1TeEiJHlQhprdZlQ" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" dim="Flow (volume)" quantityType="0" />
-                  <Parameter id="xCk3OunMfk-bfDwc2RxUDQ" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" dim="Flow (volume)" quantityType="0" />
-                  <Parameter id="yU6VtOXVDEOTQbl7k1C-pg" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="9nl7TDlzDU-5LXKjCCK5ow" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="i-xods89j02LX5mCdlV3Eg" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" dim="Dimensionless" quantityType="0" />
-                </Children>
-              </Container>
-              <Parameter id="2JhXo_q4REqeDi3f2KkY2Q" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_hrt" dim="Surface" quantityType="0" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="7hupMyN6u0yobxWtJOg_Bw" name="Heart_bc_VenousBlood_bc" description="Neighborhood between Heart/Blood Cells and Venous Blood/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="6CFlcb_lrU6luBMQ8jh8fg" secondNeighbor="td5KxHkAVkiuQetPlAwgVQ">
-            <Tags>
-              <Tag value="Heart_bc_VenousBlood_bc" />
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="yWDlPJSZbkq894Uo01D3TQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="cjQ_zuBQdkG6NQt11r9Rpw" name="Kidney_bc_VenousBlood_bc" description="Neighborhood between Kidney/Blood Cells and Venous Blood/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="t7OB_yOuqEKWnXRIgdzF5w" secondNeighbor="td5KxHkAVkiuQetPlAwgVQ">
-            <Tags>
-              <Tag value="Kidney_bc_VenousBlood_bc" />
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="vUn7X3FQakOHs-M13fcU4A" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="Uwn7zYd6d0KRnbR5fyxzBQ" name="Kidney_cell_Kidney_ur" description="Neighborhood between Kidney/Intracellular and Kidney/Urine" mode="Logical" containerType="Other" firstNeighbor="awyUty3Xo0q15yG3VtdgPw" secondNeighbor="wCRMVktFRESZSVW-L5fKcg">
-            <Tags>
-              <Tag value="Kidney_cell_Kidney_ur" />
-              <Tag value="Neighborhood: Intracellular / Urine" />
-            </Tags>
-            <Children>
-              <Container id="_WOn9xjAukyjr1sWT1STVg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="pVxzDLbJGUiZoSBPI3VeHA" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_water_cell_Kidney" dim="Dimensionless" quantityType="0" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="PDICtfk1jUCLTF22w42APA" name="Kidney_pls_Kidney_bc" description="Neighborhood between Kidney/Plasma and Kidney/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="GMY3DO0pi0WpPr2z2G0OmQ" secondNeighbor="t7OB_yOuqEKWnXRIgdzF5w">
-            <Tags>
-              <Tag value="Kidney_pls_Kidney_bc" />
-              <Tag value="Neighborhood: Plasma / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="_cUrqoCtc0y05IsOs_CAWw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              <Parameter id="GQeCC_Q8UEeEDtrodQ--hw" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" dim="Surface" quantityType="0" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="z0oHlKLTqE-9milbmrQQFQ" name="Kidney_pls_Kidney_int" description="Neighborhood between Kidney/Plasma and Kidney/Interstitial" mode="Logical" containerType="Other" firstNeighbor="GMY3DO0pi0WpPr2z2G0OmQ" secondNeighbor="bradPcqe70-hKncU74RHjw">
-            <Tags>
-              <Tag value="Kidney_pls_Kidney_int" />
-              <Tag value="Neighborhood: Plasma / Interstitial" />
-            </Tags>
-            <Children>
-              <Container id="vn04Ksx2QEC7KfXX3sJNaA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="M9fshwLquUG-bL79pFPPPQ" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" formula="uADR6c37kUizo46OPIvCUQ" dim="Velocity" quantityType="0" />
-                  <Parameter id="ohEzeFEa3k-UjwyaJyjhkw" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" dim="Dimensionless" quantityType="0" />
-                </Children>
-              </Container>
-              <Parameter id="y12PHx_d50-PTv3WDyBXaw" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" dim="Surface" quantityType="0" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="BQS7rC4FEk-hOQkgfOvuZg" name="Kidney_pls_Kidney_ur" description="Neighborhood between Kidney/Plasma and Kidney/Urine" mode="Logical" containerType="Other" firstNeighbor="GMY3DO0pi0WpPr2z2G0OmQ" secondNeighbor="wCRMVktFRESZSVW-L5fKcg">
-            <Tags>
-              <Tag value="Kidney_pls_Kidney_ur" />
-              <Tag value="Neighborhood: Plasma / Urine" />
-            </Tags>
-            <Children>
-              <Container id="5UmIsLQBXEGX_rXYqiTfZg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="M0IxgUXb3k6dmNu7SaK9Kw" name="Kidney_pls_VenousBlood_pls" description="Neighborhood between Kidney/Plasma and Venous Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="GMY3DO0pi0WpPr2z2G0OmQ" secondNeighbor="j2n6uKMQM0uCZWZ--9NUbg">
-            <Tags>
-              <Tag value="Kidney_pls_VenousBlood_pls" />
-              <Tag value="Neighborhood: Plasma / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="LDSK5IB2rUqfMCJJYOyNFg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="8pLv1JYD-kKXCCY1MCIYVA" name="Kidney_int_Kidney_cell" description="Neighborhood between Kidney/Interstitial and Kidney/Intracellular" mode="Logical" containerType="Other" firstNeighbor="bradPcqe70-hKncU74RHjw" secondNeighbor="awyUty3Xo0q15yG3VtdgPw">
-            <Tags>
-              <Tag value="Kidney_int_Kidney_cell" />
-              <Tag value="Neighborhood: Interstitial / Intracellular" />
-            </Tags>
-            <Children>
-              <Container id="iHx-bcmrgUu4T-_4oRdbxQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="23ldVTqMIEy5St2tMu-oEw" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" dim="Velocity" quantityType="0" />
-                  <Parameter id="nKSs9wAhi0SPKNVXNScF5g" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" dim="Velocity" quantityType="0" />
-                  <Parameter id="HFRwKK-SD0iHRRnbKqwsbw" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" dim="Flow (volume)" quantityType="0" />
-                  <Parameter id="03mVHiU5p0u3ebW8_1Zemw" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" dim="Flow (volume)" quantityType="0" />
-                  <Parameter id="BWdtxf14bk65Q-SXrGWBVA" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="jEMUpK3MLU6M4UaGt8lFBg" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="vbft4iE810iEzAO4uIYNIg" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="e-J7wQ0Y2kSUw47abVNWvA" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" dim="Dimensionless" quantityType="0" />
-                </Children>
-              </Container>
-              <Parameter id="AV2N9tp4SkutuhTTruVN-A" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_kid" dim="Surface" quantityType="0" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="IkavP1GZKUSv0zraOUXR5Q" name="Lumen_uje_UpperJejunum_cell" description="Neighborhood between Lumen/Upper Jejunum and Mucosa/Upper Jejunum/Intracellular" mode="Logical" containerType="Other" firstNeighbor="pv8ky3IO4EKyi5gJ8H1ypw" secondNeighbor="hh0X-zoJO0ioIifqKclJWw">
-            <Tags>
-              <Tag value="Lumen_uje_UpperJejunum_cell" />
-              <Tag value="Neighborhood: UpperJejunum / Intracellular" />
-            </Tags>
-            <Children>
-              <Container id="6OV0NCrc9U2d_Euw5MEmqw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="Fb7Ily_CQ0etLeSo7TwRFg" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K7" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="4h-wR_ItJEWqNTq8Ed8vow" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K8" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="7-mGDxmnwUyWCo6XTy1q7A" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K4" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="mBU9y6T8MES1tGLrr9DjdQ" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K4" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="Rjn6qK2pCUWd4vkmWE6-3Q" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_DrugAbsorption_trans" dim="Rate" quantityType="0" />
-                  <Parameter id="x-VrtYe0vEy_nFdXw03lhw" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_cell_lum_factor" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="IaVdksBXtECdYvfXaMvxFQ" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_lum_cell_factor" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="bNzTG_nIWk29FHgL0KdZww" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_K_cell_pls_UpperJejunum" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="mhvnQ-OfOUiIXHInsfY7xA" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_UpperJejunum" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="DQDAiCnnP0-wH8XcMpjQ9Q" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F1" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="-39S1J_S70qeUdErJl32IA" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F2" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="ry54cCl0m0SO3yxisLfqKg" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F3" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="ZKMx6788QEu3j3_cwGOsRA" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K1" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="rd6odl6CIUa_8WLIullgKw" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K6" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="5fT587k57k2Tk-EWjxq9Iw" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K3" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="2vl4tcToEU6sxtmqueXXXg" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K5" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="8E6h8SXMNEi0e87yU2f45w" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K5" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="IhJ-4d7IPkqi1Tm5KyXavg" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K6" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="rZ7xA9-4WUuHUbV8-OGkqQ" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K7" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="MZK_ny7czUe7jn4pUySx4w" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K8" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="tNEpnuM0ak23ASpQhxLUEg" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F1" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="rq5KFp7cpEOrUrYtDpdhMg" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F2" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="XaK426fjA0-TSD9kKyI8Wg" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F3" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="p4CvV_8w5kazGf75b9FGuw" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K1" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="QHnKYcgCeUaU1bFvbtRwRA" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K2" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="Jl0lfjs7E0K9FeD0UmGYCA" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K3" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="HvPpDqn4IkCq_3ii9jERjg" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K2" dim="Dimensionless" quantityType="0" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="CNDjvLLj5kmJPZ-R7OiQxA" name="UpperJejunum_bc_PortalVein_bc" description="Neighborhood between Upper Jejunum/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="WRMyELazgU6an4teJnpZQg" secondNeighbor="f1NQXRLB-0m-az7rPFpZXw">
-            <Tags>
-              <Tag value="UpperJejunum_bc_PortalVein_bc" />
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="kVB1JFIP60ucz3KfJM3idg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="Z_K_qxl6_Uum6tK3avFqZA" name="Mass transfer rate (mucosa to portal vein blood cells)" description="Mass transfer rate (mucosa to portal vein blood cells)" persistable="0" isFixedValue="0" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPveBloodCells" dim="Rate" quantityType="0" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="mL3uKtvIOU2UTGZMtacDPw" name="UpperJejunum_pls_PortalVein_pls" description="Neighborhood between Upper Jejunum/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="Y5LCVOCIvUeBojIUHl8qUg" secondNeighbor="w0IqwDHp6UGv317_8RFz7w">
-            <Tags>
-              <Tag value="UpperJejunum_pls_PortalVein_pls" />
-              <Tag value="Neighborhood: Plasma / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="kzBXociL00SK1ygxeqPeog" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="J5_F1NCwCU6e-bXAXZ_Hlw" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" persistable="0" isFixedValue="0" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPvePlasma" dim="Rate" quantityType="0" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="tvFXhx9oxkycnnAoNv6KFg" name="Lumen_uje_UpperJejunum_pls" description="Neighborhood between Lumen/Upper Jejunum and Mucosa/Upper Jejunum/Plasma" mode="Logical" containerType="Other" firstNeighbor="pv8ky3IO4EKyi5gJ8H1ypw" secondNeighbor="Y5LCVOCIvUeBojIUHl8qUg">
-            <Tags>
-              <Tag value="Lumen_uje_UpperJejunum_pls" />
-              <Tag value="Neighborhood: UpperJejunum / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="yI00eTw9yEmRdM73_Ig5lg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="X6Ob1wIIKUWVOECftJCZ6A" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_DrugAbsorption_para" dim="Rate" quantityType="0" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="1YB8QtsnHkW56ZNNaKL9FA" name="Lumen_lje_LowerJejunum_pls" description="Neighborhood between Lumen/Lower Jejunum and Mucosa/Lower Jejunum/Plasma" mode="Logical" containerType="Other" firstNeighbor="zK9Pbyu03UyPlyTlgcagCw" secondNeighbor="OSgBdGflYku_NnIddypazA">
-            <Tags>
-              <Tag value="Lumen_lje_LowerJejunum_pls" />
-              <Tag value="Neighborhood: LowerJejunum / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="DVsli6TBt0-Sc6uu0jAEdg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="mB2NVnLceEScY271A5b4xg" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_DrugAbsorption_para" dim="Rate" quantityType="0" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="1UK0HmlMT0qwBtphyQ5Veg" name="Lumen_lje_LowerJejunum_cell" description="Neighborhood between Lumen/Lower Jejunum and Mucosa/Lower Jejunum/Intracellular" mode="Logical" containerType="Other" firstNeighbor="zK9Pbyu03UyPlyTlgcagCw" secondNeighbor="e7tmWdt_iUatH8wBlrecHA">
-            <Tags>
-              <Tag value="Lumen_lje_LowerJejunum_cell" />
-              <Tag value="Neighborhood: LowerJejunum / Intracellular" />
-            </Tags>
-            <Children>
-              <Container id="LG2jKMsqM0G9iaJVEWlz5w" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="_ZwoMxtChE6zGmlmWhWSVg" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K8" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="kzGa_gj7Oken2ze7aeF7VQ" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K7" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="o0Ys-U7xh0igToqA5lKpdg" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K8" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="jo8jGoulGEK_3MK383Gvbg" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F1" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="222fDxX6uUuUsbCHPMjKaQ" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F2" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="bA0MxpxwPUOLcxsxBggV1g" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F3" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="9hOE2kaDfkGee3USeKdNng" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K1" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="amEIkmY-5EGTp4HmqYRSxQ" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K2" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="yIUqe3sdiEqRIGB8o5Eqaw" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K3" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="L-ybijDfE02g2qD3gnaL1A" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K4" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="EJ2hyRD6Pk-qSjqp0EiFeA" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K5" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="EwFPdRouCEi0skP7ZZdsVg" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K7" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="IPml6adwCUmFp1-JdyaDTA" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K6" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="mVldZcDAEEGRHSQz4YCrDw" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K4" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="hqWMKiCprE-Uf3cV4G-haA" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K6" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="SfcDm70KfESqVxvDZmo-Cw" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_cell_lum_factor" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="VnTQC9YWnUCPrE8P5d57lQ" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_DrugAbsorption_trans" dim="Rate" quantityType="0" />
-                  <Parameter id="dI4jrHPaCECiqz0yIULWag" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_lum_cell_factor" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="a6HK7UctT0mM-IHVs-WS5g" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_K_cell_pls_LowerJejunum" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="pj1TrJ9cj0-0vH9XaPWN-g" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_LowerJejunum" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="DeRxphChrk-DFiIwJ0faWg" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F1" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="MTZ0vTmKO0qx8liQiLd66Q" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F2" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="GtvSF4efA0KggG8nPNT4PA" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F3" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="4kVuY2VAb02-x6RryZkrFw" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K1" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="WxA__6nm2EeJLg1AV_2shw" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K2" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="BJ3JcbYUlEOW8ZipWV2ZRA" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K3" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="OrdX2dyYqU-boqjteAvvJw" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K5" dim="Dimensionless" quantityType="0" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="llrkXlyL2kSrubaXfcJPog" name="LowerJejunum_pls_PortalVein_pls" description="Neighborhood between Lower Jejunum/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="OSgBdGflYku_NnIddypazA" secondNeighbor="w0IqwDHp6UGv317_8RFz7w">
-            <Tags>
-              <Tag value="LowerJejunum_pls_PortalVein_pls" />
-              <Tag value="Neighborhood: Plasma / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="svBj0vzhMEKG4Pz3TRzdvA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="rEytEbw1gEyWiYqg-Xqbvg" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" persistable="0" isFixedValue="0" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPvePlasma" dim="Rate" quantityType="0" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="5gm1-GcjtEe_qA7e_AZmKg" name="LowerJejunum_bc_PortalVein_bc" description="Neighborhood between Lower Jejunum/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="md8QdYDu-E2ZDBw6wj8WEg" secondNeighbor="f1NQXRLB-0m-az7rPFpZXw">
-            <Tags>
-              <Tag value="LowerJejunum_bc_PortalVein_bc" />
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="HfdnRdvX7EeBR2Z2WziNbA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="pFM8PoCz70imR8NZ-gl27g" name="Mass transfer rate (mucosa to portal vein blood cells)" description="Mass transfer rate (mucosa to portal vein blood cells)" persistable="0" isFixedValue="0" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPveBloodCells" dim="Rate" quantityType="0" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="og38RUAmDUGzrZVKfYZfPw" name="Lumen_coldesc_Lumen_colsigm" description="Neighborhood between Lumen/Colon Descendens and Lumen/Colon Sigmoid" mode="Logical" containerType="Other" firstNeighbor="hCfl5QSnmkScQGM_92IC7A" secondNeighbor="Bi4ZMIHKqEWJTZaSDxNssw">
-            <Tags>
-              <Tag value="Lumen_coldesc_Lumen_colsigm" />
-              <Tag value="Neighborhood: ColonDescendens / ColonSigmoid" />
-            </Tags>
-            <Children>
-              <Container id="yVC-ylVnR0-XKnIGxUkyQw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="4eDb51HNwkKk1LOwXcUF8Q" name="Lumen_sto_Lumen_duo" description="Neighborhood between Lumen/Stomach and Lumen/Duodenum" mode="Logical" containerType="Other" firstNeighbor="hnGAUcV_iUqKJigxybLqhQ" secondNeighbor="0GDB2v61NEaYOE7qtRF98A">
-            <Tags>
-              <Tag value="Lumen_sto_Lumen_duo" />
-              <Tag value="Neighborhood: Stomach / Duodenum" />
-            </Tags>
-            <Children>
-              <Container id="ghrh6ez4XUibKzkYzqObWg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="mTJ70pbQGU-O2lKi7H7zyw" name="Oral mass absorbed" description="Oral mass absorbed from Lumen into mucosa" persistable="0" isFixedValue="0" formula="d0mzm_bYJUyaSt-5fZUR8g" dim="Amount" quantityType="0" rHSFormula="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="tuj31FMihkyk9ev3GZW5aw" name="Lumen_uje_Lumen_lje" description="Neighborhood between Lumen/Upper Jejunum and Lumen/Lower Jejunum" mode="Logical" containerType="Other" firstNeighbor="pv8ky3IO4EKyi5gJ8H1ypw" secondNeighbor="zK9Pbyu03UyPlyTlgcagCw">
-            <Tags>
-              <Tag value="Lumen_uje_Lumen_lje" />
-              <Tag value="Neighborhood: UpperJejunum / LowerJejunum" />
-            </Tags>
-            <Children>
-              <Container id="1y_iwHiAWEWPOw8IxvwWtQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="C3aNzVvF2US6iuWvtmyIuw" name="Lumen_uil_Lumen_lil" description="Neighborhood between Lumen/Upper Ileum and Lumen/Lower Ileum" mode="Logical" containerType="Other" firstNeighbor="Lyr8qWpSH02MuqWATY6opQ" secondNeighbor="fEBnSbA_6USbWW4hwxLwgA">
-            <Tags>
-              <Tag value="Lumen_uil_Lumen_lil" />
-              <Tag value="Neighborhood: UpperIleum / LowerIleum" />
-            </Tags>
-            <Children>
-              <Container id="a-9HHkiVbEOFo7mbsSwFxA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="F4TUySsNSEGfoeepEezTKA" name="Lumen_lil_Lumen_cae" description="Neighborhood between Lumen/Lower Ileum and Lumen/Cecum" mode="Logical" containerType="Other" firstNeighbor="fEBnSbA_6USbWW4hwxLwgA" secondNeighbor="Tb_XB9kBdEijMjvfTLCFmg">
-            <Tags>
-              <Tag value="Lumen_lil_Lumen_cae" />
-              <Tag value="Neighborhood: LowerIleum / Caecum" />
-            </Tags>
-            <Children>
-              <Container id="uhx_WefXUkSSuSdxGFkNWg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="eXzKTcZg7kq2aOR3TiDVDg" name="Lumen_cae_Lumen_colasc" description="Neighborhood between Lumen/Cecum and Lumen/Colon Ascendens" mode="Logical" containerType="Other" firstNeighbor="Tb_XB9kBdEijMjvfTLCFmg" secondNeighbor="px9VS6HKjEufLOLkVEmyiQ">
-            <Tags>
-              <Tag value="Lumen_cae_Lumen_colasc" />
-              <Tag value="Neighborhood: Caecum / ColonAscendens" />
-            </Tags>
-            <Children>
-              <Container id="87MMddVtA0CyJFRoB0seKw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="KBuUN-gFpkyKBpLOv14SmA" name="Lumen_colasc_Lumen_coltrans" description="Neighborhood between Lumen/Colon Ascendens and Lumen/Colon Transversum" mode="Logical" containerType="Other" firstNeighbor="px9VS6HKjEufLOLkVEmyiQ" secondNeighbor="0VK_KFeZDUK2wXtt8tiCFw">
-            <Tags>
-              <Tag value="Lumen_colasc_Lumen_coltrans" />
-              <Tag value="Neighborhood: ColonAscendens / ColonTransversum" />
-            </Tags>
-            <Children>
-              <Container id="t32QRgnhSEeJA7pmDhwKxA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="NTQT0PP600uvy4eZpk6aXA" name="Lumen_coltrans_Lumen_coldesc" description="Neighborhood between Lumen/Colon Transversum and Lumen/Colon Descendens" mode="Logical" containerType="Other" firstNeighbor="0VK_KFeZDUK2wXtt8tiCFw" secondNeighbor="hCfl5QSnmkScQGM_92IC7A">
-            <Tags>
-              <Tag value="Lumen_coltrans_Lumen_coldesc" />
-              <Tag value="Neighborhood: ColonTransversum / ColonDescendens" />
-            </Tags>
-            <Children>
-              <Container id="k6nu2qYabUmDPUztnNFcDQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="7nPJuOUpU0W82EvSRl-f6A" name="Lumen_lje_Lumen_uil" description="Neighborhood between Lumen/Lower Jejunum and Lumen/Upper Ileum" mode="Logical" containerType="Other" firstNeighbor="zK9Pbyu03UyPlyTlgcagCw" secondNeighbor="Lyr8qWpSH02MuqWATY6opQ">
-            <Tags>
-              <Tag value="Lumen_lje_Lumen_uil" />
-              <Tag value="Neighborhood: LowerJejunum / UpperIleum" />
-            </Tags>
-            <Children>
-              <Container id="w-SXaJzCjE2IjSShU8GVAQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="KfHRqXkj9U-GD2ZBVnljAw" name="Lumen_duo_Lumen_uje" description="Neighborhood between Lumen/Duodenum and Lumen/Upper Jejunum" mode="Logical" containerType="Other" firstNeighbor="0GDB2v61NEaYOE7qtRF98A" secondNeighbor="pv8ky3IO4EKyi5gJ8H1ypw">
-            <Tags>
-              <Tag value="Lumen_duo_Lumen_uje" />
-              <Tag value="Neighborhood: Duodenum / UpperJejunum" />
-            </Tags>
-            <Children>
-              <Container id="SoF1FZjOvk6GDs4IXiNhyQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="xqm5cGpagE2T4NXpmLrVSw" name="Lumen_colsigm_Lumen_rect" description="Neighborhood between Lumen/Colon Sigmoid and Lumen/Rectum" mode="Logical" containerType="Other" firstNeighbor="Bi4ZMIHKqEWJTZaSDxNssw" secondNeighbor="BSo2lLHrCkGHE23rSU5SRw">
-            <Tags>
-              <Tag value="Lumen_colsigm_Lumen_rect" />
-              <Tag value="Neighborhood: ColonSigmoid / Rectum" />
-            </Tags>
-            <Children>
-              <Container id="3pLi61flZE2x6z0DEbhdmg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="n7uHhBBX3UO9aa584pVf0w" name="Lumen_rect_Lumen_fec" description="Neighborhood between Lumen/Rectum and Lumen/Feces" mode="Logical" containerType="Other" firstNeighbor="BSo2lLHrCkGHE23rSU5SRw" secondNeighbor="7r-hCC6l_EqDsW0kbuL8tA">
-            <Tags>
-              <Tag value="Lumen_rect_Lumen_fec" />
-              <Tag value="Neighborhood: Rectum / Feces" />
-            </Tags>
-            <Children>
-              <Container id="pN-mQ5ABX0Gwz6T8M1MA2A" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="vw9UcexdL0q0akvF6W0YYw" name="Stomach_int_Stomach_cell" description="Neighborhood between Stomach/Interstitial and Stomach/Intracellular" mode="Logical" containerType="Other" firstNeighbor="qy33QgWMT0asBh6M83zXDg" secondNeighbor="HVHehptfYU29BpEja2I2vA">
-            <Tags>
-              <Tag value="Stomach_int_Stomach_cell" />
-              <Tag value="Neighborhood: Interstitial / Intracellular" />
-            </Tags>
-            <Children>
-              <Container id="if3SeAo6n0u8Q6miyff7TQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="rCrLTx4jPkugnUsJ_dQt6w" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="-8PnfqjYiU-swOFXifTxDg" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" dim="Velocity" quantityType="0" />
-                  <Parameter id="XGmNymV9H0GK-GZsjauiFA" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" dim="Velocity" quantityType="0" />
-                  <Parameter id="G-p3jQI2s069r7totKoA-w" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" dim="Flow (volume)" quantityType="0" />
-                  <Parameter id="iOWJv4XPIEyFvLYW-jarMA" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="lFcstkkNV0agX7XO-_8Eyg" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="BVMdjRCF202bNFvqtVxfUQ" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="JZN4jYV-lkKmXXCVWt1aZg" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" dim="Flow (volume)" quantityType="0" />
-                </Children>
-              </Container>
-              <Parameter id="sxr8UDX4Y0i2FjsVHYUpVw" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_sto" dim="Surface" quantityType="0" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="GY95FL1IlECrLzATP8cMfw" name="Stomach_pls_PortalVein_pls" description="Neighborhood between Stomach/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="pVA-97xMJk2pIZRvafTI-w" secondNeighbor="w0IqwDHp6UGv317_8RFz7w">
-            <Tags>
-              <Tag value="Stomach_pls_PortalVein_pls" />
-              <Tag value="Neighborhood: Plasma / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="dNHa9TQQU0eE4BY694-l8A" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="3k6sBJjl-kuz4y7P4frEaw" name="Stomach_bc_PortalVein_bc" description="Neighborhood between Stomach/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="6rJ8cqge0U28pltXPlJSGg" secondNeighbor="f1NQXRLB-0m-az7rPFpZXw">
-            <Tags>
-              <Tag value="Stomach_bc_PortalVein_bc" />
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="PsmAI8yejUqeeZgVF3X7qw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="y-ZqTaYS60agKneRhniMHw" name="Stomach_pls_Stomach_int" description="Neighborhood between Stomach/Plasma and Stomach/Interstitial" mode="Logical" containerType="Other" firstNeighbor="pVA-97xMJk2pIZRvafTI-w" secondNeighbor="qy33QgWMT0asBh6M83zXDg">
-            <Tags>
-              <Tag value="Stomach_pls_Stomach_int" />
-              <Tag value="Neighborhood: Plasma / Interstitial" />
-            </Tags>
-            <Children>
-              <Container id="5M-DWF-RsU-wKDmger8cYw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="qLk4pDMQikOpGiBJCfbzHg" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" formula="MKIC_fnd8Uyiz3I_jWqQAw" dim="Velocity" quantityType="0" />
-                  <Parameter id="SQUN4kVyI0WoiOLobD7z-Q" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" dim="Dimensionless" quantityType="0" />
-                </Children>
-              </Container>
-              <Parameter id="EIJ66JiFO02XrJWvvoRdPw" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" dim="Surface" quantityType="0" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="wUdq5jZzIE-Wx6IBriRq1Q" name="Stomach_pls_Stomach_bc" description="Neighborhood between Stomach/Plasma and Stomach/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="pVA-97xMJk2pIZRvafTI-w" secondNeighbor="6rJ8cqge0U28pltXPlJSGg">
-            <Tags>
-              <Tag value="Stomach_pls_Stomach_bc" />
-              <Tag value="Neighborhood: Plasma / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="F4NYow26aU69wkwJTR4NsA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              <Parameter id="X-TTE0FbgUmjJcezkcvqQw" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" dim="Surface" quantityType="0" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="Enm8MnepYEa0811rZF7QBw" name="Lumen_uil_UpperIleum_pls" description="Neighborhood between Lumen/Upper Ileum and Mucosa/Upper Ileum/Plasma" mode="Logical" containerType="Other" firstNeighbor="Lyr8qWpSH02MuqWATY6opQ" secondNeighbor="66G9xUKPyECPdQdGwnYfSw">
-            <Tags>
-              <Tag value="Lumen_uil_UpperIleum_pls" />
-              <Tag value="Neighborhood: UpperIleum / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="TMy2D-98_E6eaKzMmlgaXg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="_PyNuOm00EyvSjYAEqcP2A" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_DrugAbsorption_para" dim="Rate" quantityType="0" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="h6PbYcZuC0CkdI0XQbTnVA" name="Lumen_uil_UpperIleum_cell" description="Neighborhood between Lumen/Upper Ileum and Mucosa/Upper Ileum/Intracellular" mode="Logical" containerType="Other" firstNeighbor="Lyr8qWpSH02MuqWATY6opQ" secondNeighbor="_XEu4SuUvUqKPjzK6x0c8w">
-            <Tags>
-              <Tag value="Lumen_uil_UpperIleum_cell" />
-              <Tag value="Neighborhood: UpperIleum / Intracellular" />
-            </Tags>
-            <Children>
-              <Container id="IfpG8QHMeEmnU526yZlfgw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="npPKpjv1aEe4h7cl8gZDDw" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K8" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="eBcuVtDEI0-bk_AZEZO7Sw" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K8" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="sQmtmYyHpE6zCbzudNHxDA" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_UpperIleum" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="g-rZgAIpVECa4Y-CUkPV7A" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F1" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="DGmBDer30k-ckxnYHyFJZg" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F2" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="vdp_ECy52kC5vhUTRMnQfA" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F3" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="u7ia7vaxxUmHXZlaTvvhcQ" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K1" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="FFVEwT0mE0a207OQgxbqDA" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K2" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="XRKkOTUsvEW7CTX-cp5vbw" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K3" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="XMiLxMkh80WfoiLQhewq6Q" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K4" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="ijupmJ2D9UGehgSb-FPfnw" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K5" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="1yOdbCT6nUOdLs8J1aJ6_g" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_lum_cell_factor" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="uQiCCURHwEyXxp8rks7NDQ" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K7" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="Xwz5rUD7KkynOJ1eHf5R1w" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_cell_lum_factor" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="QltEv68NQUSs6Qx7Fv4TSg" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F1" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="QpIOoL5OT0m1JWXDCWRDww" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F2" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="JjmJCpAiukGrEHxjzBgcXw" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F3" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="EqzM_RbArkKNnjJkM37Uzw" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K1" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="fW5XoA_BtUC5OrC8ENEWSg" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K2" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="1DsVYLd5VEW73moL-p84BA" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K3" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="pfFJk2HUWkme3dleWooqAQ" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K4" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="p5djaszPLEyljMVy2CynPw" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K5" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="AU8Kvu2eAUu-v9NDUxFH0A" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K6" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="14C3QZ-rQU2_vyhS5B0uwA" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K6" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="0c4ohsRvtUGEdb44Q0f2jQ" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_K_cell_pls_UpperIleum" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="ooCijnFYW0uB41LLY8VYpQ" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_DrugAbsorption_trans" dim="Rate" quantityType="0" />
-                  <Parameter id="LRdxGlqFPUWpvIxgWMgEJA" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K7" dim="Dimensionless" quantityType="0" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="Ky8VYXQ_L0u6iqK7BF1BIQ" name="UpperIleum_pls_PortalVein_pls" description="Neighborhood between Upper Ileum/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="66G9xUKPyECPdQdGwnYfSw" secondNeighbor="w0IqwDHp6UGv317_8RFz7w">
-            <Tags>
-              <Tag value="UpperIleum_pls_PortalVein_pls" />
-              <Tag value="Neighborhood: Plasma / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="w7LjYSJ56kmd6aXJC8dWtw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="hhMPo-1_j0qc77BP2DBR9A" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" persistable="0" isFixedValue="0" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPvePlasma" dim="Rate" quantityType="0" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="ZpFfVdJOW0OpYdaCeQzyXw" name="UpperIleum_bc_PortalVein_bc" description="Neighborhood between Upper Ileum/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="VDYdAer0LkaTdqAFYYkuhg" secondNeighbor="f1NQXRLB-0m-az7rPFpZXw">
-            <Tags>
-              <Tag value="UpperIleum_bc_PortalVein_bc" />
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="jqwq6vGNkEaQk0FJ9k5IvQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="dl6uxio6bU2CGjaWJ-H-Gw" name="Mass transfer rate (mucosa to portal vein blood cells)" description="Mass transfer rate (mucosa to portal vein blood cells)" persistable="0" isFixedValue="0" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPveBloodCells" dim="Rate" quantityType="0" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="8a1XySljIEqcWgHkIIHFBA" name="SmallIntestine_pls_SmallIntestine_bc" description="Neighborhood between Small Intestine/Plasma and Small Intestine/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="9bNBf7f5bECO2rVlpa9ohg" secondNeighbor="aSoZ2sizDky7iyqNn7-KEg">
-            <Tags>
-              <Tag value="SmallIntestine_pls_SmallIntestine_bc" />
-              <Tag value="Neighborhood: Plasma / BloodCells" />
-              <Tag value="Small intestine  neighborhood" />
-            </Tags>
-            <Children>
-              <Container id="kvAK8XeqD0qDy6Az2Z7h8g" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              <Parameter id="O9pDFi54vUmsdLdn-2PQUA" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls_sinlin" dim="Surface" quantityType="0" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="HEQt8g-dX0CEOkjyC0cvjA" name="SmallIntestine_bc_PortalVein_bc" description="Neighborhood between Small Intestine/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="aSoZ2sizDky7iyqNn7-KEg" secondNeighbor="f1NQXRLB-0m-az7rPFpZXw">
-            <Tags>
-              <Tag value="SmallIntestine_bc_PortalVein_bc" />
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="v2M97_9SvUKuz5sgjaHXWg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="DOORrJcoT0-7vhlZWzctgg" name="SmallIntestine_pls_SmallIntestine_int" description="Neighborhood between Small Intestine/Plasma and Small Intestine/Interstitial" mode="Logical" containerType="Other" firstNeighbor="9bNBf7f5bECO2rVlpa9ohg" secondNeighbor="oqAJaFWZKki03c9kilSh2Q">
-            <Tags>
-              <Tag value="SmallIntestine_pls_SmallIntestine_int" />
-              <Tag value="Neighborhood: Plasma / Interstitial" />
-              <Tag value="Small intestine  neighborhood" />
-            </Tags>
-            <Children>
-              <Container id="fCpQx0NlCUGAqogquGJvcQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="vKho4WGXJ0K5k9waMCDT-w" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="1XGI-7Kjy02WxfgKzTHA_w" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" formula="2Df1qoSvvEOjneiXFLtuSw" dim="Velocity" quantityType="0" />
-                </Children>
-              </Container>
-              <Parameter id="yzcwr8bcyEymJMf6pTeQOw" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int_sinlin" dim="Surface" quantityType="0" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="8yEFUQXIa0mLm9HwLNy5IQ" name="SmallIntestine_pls_PortalVein_pls" description="Neighborhood between Small Intestine/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="9bNBf7f5bECO2rVlpa9ohg" secondNeighbor="w0IqwDHp6UGv317_8RFz7w">
-            <Tags>
-              <Tag value="SmallIntestine_pls_PortalVein_pls" />
-              <Tag value="Neighborhood: Plasma / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="C0tx_kWdrEmIpNFEAj1qlg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="JMuUj5HUxU2xzorRptsKaQ" name="SmallIntestine_int_SmallIntestine_cell" description="Neighborhood between Small Intestine/Interstitial and Small Intestine/Intracellular" mode="Logical" containerType="Other" firstNeighbor="oqAJaFWZKki03c9kilSh2Q" secondNeighbor="ULhix8ymhkqjAN0AfH3VDg">
-            <Tags>
-              <Tag value="SmallIntestine_int_SmallIntestine_cell" />
-              <Tag value="Neighborhood: Interstitial / Intracellular" />
-              <Tag value="Small intestine  neighborhood" />
-            </Tags>
-            <Children>
-              <Container id="f_m8SktlE0eavENgZyPGBA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="HIR5hATBMEqMc1fJ7wvY-Q" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" dim="Velocity" quantityType="0" />
-                  <Parameter id="s-RLcYLL40WFuFvoK5Iv-A" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" dim="Velocity" quantityType="0" />
-                  <Parameter id="d3nHZn3ir02becLdFkF5fw" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" dim="Flow (volume)" quantityType="0" />
-                  <Parameter id="i3lRpDw23UuFepu87HOqRg" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" dim="Flow (volume)" quantityType="0" />
-                  <Parameter id="aNzEmFQ9T0C3B8qTLHaJyQ" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="z4M8DCWX3Emnmagaii6vvA" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="Mj8k-oEgDkao1blgBqL9IQ" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="t-mb5BYBSkClaL3PerWSnQ" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" dim="Dimensionless" quantityType="0" />
-                </Children>
-              </Container>
-              <Parameter id="ipyaQqSsoUCiwzU5hwcsIQ" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_sin" dim="Surface" quantityType="0" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="Rxu4OAxv0UKAQkwWDwbBhQ" name="SmallIntestine_bc_LowerIleum_bc" description="Neighborhood between Small Intestine/Blood Cells_ and Lower Ileum/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="aSoZ2sizDky7iyqNn7-KEg" secondNeighbor="MFDAv_PfOkiQzDjjkslSHw">
-            <Tags>
-              <Tag value="SmallIntestine_bc_LowerIleum_bc" />
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="6_3pMAIog06_V1poTTaPJQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="rUa7cvh1ckynHfvb0NURMA" name="Mass transfer rate (intestine to mucosa blood cells)" description="Mass transfer rate (intestine to mucosa blood cells)" persistable="0" isFixedValue="0" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaBloodCells" dim="Rate" quantityType="0" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="G-UQueSasECmTkCXxzIVUA" name="SmallIntestine_pls_Duodenum_pls" description="Neighborhood between Small Intestine/Plasma_ and Duodenum/Plasma" mode="Logical" containerType="Other" firstNeighbor="9bNBf7f5bECO2rVlpa9ohg" secondNeighbor="Uw8BHY6NWESXphEVCwU2-Q">
-            <Tags>
-              <Tag value="SmallIntestine_pls_Duodenum_pls" />
-              <Tag value="Neighborhood: Plasma / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="1xsfFKeV30GtPVTJL2WU8A" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="eYF03K-Tvk2OYFnbCGVpjg" name="Mass transfer rate (intestine to mucosa plasma)" description="Mass transfer rate (intestine to mucosa plasma)" persistable="0" isFixedValue="0" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaPlasma" dim="Rate" quantityType="0" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="gE90quY3T0yCNoUJ2SnFDA" name="SmallIntestine_bc_Duodenum_bc" description="Neighborhood between Small Intestine/Blood Cells_ and Duodenum/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="aSoZ2sizDky7iyqNn7-KEg" secondNeighbor="pkv5-3lim0ytLpaYYc02Bg">
-            <Tags>
-              <Tag value="SmallIntestine_bc_Duodenum_bc" />
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="sgzTIHTBj0GOz-cHj2os_Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="cGt1jZmrzUyV8VYcT_ORjA" name="Mass transfer rate (intestine to mucosa blood cells)" description="Mass transfer rate (intestine to mucosa blood cells)" persistable="0" isFixedValue="0" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaBloodCells" dim="Rate" quantityType="0" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="rtqQWFLqgEeloG3WKbDPNw" name="SmallIntestine_pls_UpperJejunum_pls" description="Neighborhood between Small Intestine/Plasma_ and Upper Jejunum/Plasma" mode="Logical" containerType="Other" firstNeighbor="9bNBf7f5bECO2rVlpa9ohg" secondNeighbor="Y5LCVOCIvUeBojIUHl8qUg">
-            <Tags>
-              <Tag value="SmallIntestine_pls_UpperJejunum_pls" />
-              <Tag value="Neighborhood: Plasma / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="esWjx0xQ2UmQrmkgIuXUUw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="yBv8GjsvKkypycO3wdD8xA" name="Mass transfer rate (intestine to mucosa plasma)" description="Mass transfer rate (intestine to mucosa plasma)" persistable="0" isFixedValue="0" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaPlasma" dim="Rate" quantityType="0" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="rqA-2F_R8UOtgI4AzayF1A" name="SmallIntestine_bc_UpperJejunum_bc" description="Neighborhood between Small Intestine/Blood Cells_ and Upper Jejunum/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="aSoZ2sizDky7iyqNn7-KEg" secondNeighbor="WRMyELazgU6an4teJnpZQg">
-            <Tags>
-              <Tag value="SmallIntestine_bc_UpperJejunum_bc" />
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="Z7vy5N1g0E22gDxWb_QehQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="2Cnm1-RDCkCdsHvRlZtOWg" name="Mass transfer rate (intestine to mucosa blood cells)" description="Mass transfer rate (intestine to mucosa blood cells)" persistable="0" isFixedValue="0" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaBloodCells" dim="Rate" quantityType="0" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="rwCyutFZfE6kKuZYhqdiXA" name="SmallIntestine_pls_LowerJejunum_pls" description="Neighborhood between Small Intestine/Plasma_ and Lower Jejunum/Plasma" mode="Logical" containerType="Other" firstNeighbor="9bNBf7f5bECO2rVlpa9ohg" secondNeighbor="OSgBdGflYku_NnIddypazA">
-            <Tags>
-              <Tag value="SmallIntestine_pls_LowerJejunum_pls" />
-              <Tag value="Neighborhood: Plasma / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="YoNmm0vPxkmNTVfhpaLPdQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="MaoIqbaqW0qf7oGS8Ci_kg" name="Mass transfer rate (intestine to mucosa plasma)" description="Mass transfer rate (intestine to mucosa plasma)" persistable="0" isFixedValue="0" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaPlasma" dim="Rate" quantityType="0" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="F8tpL5JI-0WuVl75LgVl5Q" name="SmallIntestine_bc_LowerJejunum_bc" description="Neighborhood between Small Intestine/Blood Cells_ and Lower Jejunum/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="aSoZ2sizDky7iyqNn7-KEg" secondNeighbor="md8QdYDu-E2ZDBw6wj8WEg">
-            <Tags>
-              <Tag value="SmallIntestine_bc_LowerJejunum_bc" />
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="RCmULKC6YU-S0IkX1DIe7w" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="Hk_gJQu3r0W8tlWeBU5dLA" name="Mass transfer rate (intestine to mucosa blood cells)" description="Mass transfer rate (intestine to mucosa blood cells)" persistable="0" isFixedValue="0" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaBloodCells" dim="Rate" quantityType="0" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="Nmpwf0GMeEeO4Zje8SoQlg" name="SmallIntestine_pls_UpperIleum_pls" description="Neighborhood between Small Intestine/Plasma_ and Upper Ileum/Plasma" mode="Logical" containerType="Other" firstNeighbor="9bNBf7f5bECO2rVlpa9ohg" secondNeighbor="66G9xUKPyECPdQdGwnYfSw">
-            <Tags>
-              <Tag value="SmallIntestine_pls_UpperIleum_pls" />
-              <Tag value="Neighborhood: Plasma / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="WnF5eqVzkki7H7-RbihRNA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="zaZ0ffom90uRpzCTAFhkhw" name="Mass transfer rate (intestine to mucosa plasma)" description="Mass transfer rate (intestine to mucosa plasma)" persistable="0" isFixedValue="0" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaPlasma" dim="Rate" quantityType="0" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="g9XrWxsnbEuqVK_A9uuEEA" name="SmallIntestine_bc_UpperIleum_bc" description="Neighborhood between Small Intestine/Blood Cells_ and Upper Ileum/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="aSoZ2sizDky7iyqNn7-KEg" secondNeighbor="VDYdAer0LkaTdqAFYYkuhg">
-            <Tags>
-              <Tag value="SmallIntestine_bc_UpperIleum_bc" />
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="2FXCRj3sYEOAiL1SQFBcCA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="H-tXGfgLAkSEviqDY9jzwQ" name="Mass transfer rate (intestine to mucosa blood cells)" description="Mass transfer rate (intestine to mucosa blood cells)" persistable="0" isFixedValue="0" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaBloodCells" dim="Rate" quantityType="0" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="J0QfSXduZEOpRsFNog19ug" name="Lumen_lil_LowerIleum_pls" description="Neighborhood between Lumen/Lower Ileum and Mucosa/Lower Ileum/Plasma" mode="Logical" containerType="Other" firstNeighbor="fEBnSbA_6USbWW4hwxLwgA" secondNeighbor="HOj-zR3PPUW6yX-B0rLz0g">
-            <Tags>
-              <Tag value="Lumen_lil_LowerIleum_pls" />
-              <Tag value="Neighborhood: LowerIleum / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="AbRaHP15xUiKgrSWZ0u6vw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="CUScMSwvXUKCcCbDqIrQhg" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_DrugAbsorption_para" dim="Rate" quantityType="0" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="ZIXqzJHAL0K9XvQSv27r3A" name="SmallIntestine_pls_LowerIleum_pls" description="Neighborhood between Small Intestine/Plasma_ and Lower Ileum/Plasma" mode="Logical" containerType="Other" firstNeighbor="9bNBf7f5bECO2rVlpa9ohg" secondNeighbor="HOj-zR3PPUW6yX-B0rLz0g">
-            <Tags>
-              <Tag value="SmallIntestine_pls_LowerIleum_pls" />
-              <Tag value="Neighborhood: Plasma / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="zQHkdFTSRku2pckFwqYn-g" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="VMGd_2iIH0WcDAxvJfF6Jw" name="Mass transfer rate (intestine to mucosa plasma)" description="Mass transfer rate (intestine to mucosa plasma)" persistable="0" isFixedValue="0" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaPlasma" dim="Rate" quantityType="0" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="CaFOdSsia0GRG1m2Fm3U7A" name="LowerIleum_pls_PortalVein_pls" description="Neighborhood between Lower Ileum/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="HOj-zR3PPUW6yX-B0rLz0g" secondNeighbor="w0IqwDHp6UGv317_8RFz7w">
-            <Tags>
-              <Tag value="LowerIleum_pls_PortalVein_pls" />
-              <Tag value="Neighborhood: Plasma / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="ChIgAcM3nUCnouSZWiDubg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="ixaaLI5L_EWxeFb3pzAVMQ" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" persistable="0" isFixedValue="0" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPvePlasma" dim="Rate" quantityType="0" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="evpi-XjJQkCGtaYdbhqOTA" name="LowerIleum_bc_PortalVein_bc" description="Neighborhood between Lower Ileum/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="MFDAv_PfOkiQzDjjkslSHw" secondNeighbor="f1NQXRLB-0m-az7rPFpZXw">
-            <Tags>
-              <Tag value="LowerIleum_bc_PortalVein_bc" />
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="wGzfI8XdwkagElP_Tc63YA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="YGL5z5zutE-026RgZepqKQ" name="Mass transfer rate (mucosa to portal vein blood cells)" description="Mass transfer rate (mucosa to portal vein blood cells)" persistable="0" isFixedValue="0" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPveBloodCells" dim="Rate" quantityType="0" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="lLBbm2pXo0ixLsyYLGLPBg" name="Lumen_lil_LowerIleum_cell" description="Neighborhood between Lumen/Lower Ileum and Mucosa/Lower Ileum/Intracellular" mode="Logical" containerType="Other" firstNeighbor="fEBnSbA_6USbWW4hwxLwgA" secondNeighbor="O2GTTPwRekuvYZ3QMo8Raw">
-            <Tags>
-              <Tag value="Lumen_lil_LowerIleum_cell" />
-              <Tag value="Neighborhood: LowerIleum / Intracellular" />
-            </Tags>
-            <Children>
-              <Container id="0GqbmnThuUaAt5o1z4rF9Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="A_W_zPF0hUmXRvl9I-_ebw" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F3" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="juKonisNgE2GOgn7w0agGw" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K1" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="-NV88Hrp8U-Ex-qopEIKkw" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K2" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="4u3kAErRG0KERXIwTwDnkQ" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K3" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="abwpuKwGN0KfNWTWEGsXYQ" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K4" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="ZJEigMTN1EyOEZfEabdl5A" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K5" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="keyQ3amxd02BpCXOO0I4ow" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K6" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="w52fnhxC-kS9Et3NeDFLIw" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K7" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="hL0DoNZi8kW-Be6r2Yf5Ig" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K8" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="nXURS9QvWEaGnwVprMhTVA" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F1" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="LyeXyglG806X9suLLRcJ_w" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K8" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="p2A-VWXzK0a84LdT-B1_bg" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_LowerIleum" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="EjMr_fV1mk-aFiYfkR7Dhg" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_DrugAbsorption_trans" dim="Rate" quantityType="0" />
-                  <Parameter id="4tM4q4A-MkOCzo7s7YzvCg" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_cell_lum_factor" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="qBcPmfn1H0eL3BwRlmvJtg" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F2" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="4hKvE3Qyq0eU0S3pmcwa-w" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_K_cell_pls_LowerIleum" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="J1JlUgm3akCWPLxLorRkZQ" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F1" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="DhraXbwUA0qKFSDFCxqyZg" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F2" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="4ti8EzMIUEisW71p2kVF5A" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F3" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="oxcUGa-S3kqnU-wgL8NgTg" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K1" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="uqXDTVCFHEuMmefiB81PJA" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K2" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="1fOTP83glUuZstjnRgARFg" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K3" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="Gy1kh8UOrUig1QsuBJd8tA" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K4" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="l0fVFBkSMU2btqCWUXQ7Lg" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K5" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="o9WmhdyYPkKP1HA2tPTSqw" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K6" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="un7LMyJEqUaeGa9rzfRgAA" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K7" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="wTEqNX94OkmgaCfsGhyTaQ" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_lum_cell_factor" dim="Dimensionless" quantityType="0" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="LpI_nCWIyk-rCZZTdWY0wg" name="LargeIntestine_bc_Rectum_bc" description="Neighborhood between Large Intestine/Blood Cells_ and Rectum/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="4VlXh1FvuEi4iThCgPo84g" secondNeighbor="udxtFKMRFUe0Mj2-C-W3hg">
-            <Tags>
-              <Tag value="LargeIntestine_bc_Rectum_bc" />
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="3HiwvZYk70KOjKP4OyOU0A" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="f8KyC_GMLU-WwlcSaE-d3Q" name="Mass transfer rate (intestine to mucosa blood cells)" description="Mass transfer rate (intestine to mucosa blood cells)" persistable="0" isFixedValue="0" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaBloodCells" dim="Rate" quantityType="0" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="KOfnFadWt0Cc8p3TXsP1OA" name="LargeIntestine_pls_Rectum_pls" description="Neighborhood between Large Intestine/Plasma_ and Rectum/Plasma" mode="Logical" containerType="Other" firstNeighbor="KnL-t0swKEGlt4XXJPF8sA" secondNeighbor="eJzNOCYba06diGWhCWqi1Q">
-            <Tags>
-              <Tag value="LargeIntestine_pls_Rectum_pls" />
-              <Tag value="Neighborhood: Plasma / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="0VFlgDNE_E2jC45OpvYNSQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="b_lJp-zHg0WNcoPGDEtbqg" name="Mass transfer rate (intestine to mucosa plasma)" description="Mass transfer rate (intestine to mucosa plasma)" persistable="0" isFixedValue="0" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaPlasma" dim="Rate" quantityType="0" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="8DjtgO6Gj0iEq_TuxquUGw" name="LargeIntestine_bc_ColonSigmoid_bc" description="Neighborhood between Large Intestine/Blood Cells_ and Colon Sigmoid/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="4VlXh1FvuEi4iThCgPo84g" secondNeighbor="Yo5tHCCFQUekhjV8Ghb7RQ">
-            <Tags>
-              <Tag value="LargeIntestine_bc_ColonSigmoid_bc" />
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="K7l4mAf0skaUVfQwpl6yUQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="kqyztdpF6Eu-0ruUHCOm0Q" name="Mass transfer rate (intestine to mucosa blood cells)" description="Mass transfer rate (intestine to mucosa blood cells)" persistable="0" isFixedValue="0" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaBloodCells" dim="Rate" quantityType="0" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="An_oS8D2fEKzNkx5rKgavg" name="LargeIntestine_pls_ColonSigmoid_pls" description="Neighborhood between Large Intestine/Plasma_ and Colon Sigmoid/Plasma" mode="Logical" containerType="Other" firstNeighbor="KnL-t0swKEGlt4XXJPF8sA" secondNeighbor="FyoEzv-8O0WMSz47wtJ9gg">
-            <Tags>
-              <Tag value="LargeIntestine_pls_ColonSigmoid_pls" />
-              <Tag value="Neighborhood: Plasma / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="Orx9jwV8CEWqoqJ0iMM1cg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="cggQGde8nUWuRALqkuxLbQ" name="Mass transfer rate (intestine to mucosa plasma)" description="Mass transfer rate (intestine to mucosa plasma)" persistable="0" isFixedValue="0" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaPlasma" dim="Rate" quantityType="0" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="gik0-PV5CE2eXn7UVYkXnQ" name="LargeIntestine_bc_ColonDescendens_bc" description="Neighborhood between Large Intestine/Blood Cells_ and Colon Descendens/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="4VlXh1FvuEi4iThCgPo84g" secondNeighbor="XK3vUE0RlU2Uq4VMEUyDFQ">
-            <Tags>
-              <Tag value="LargeIntestine_bc_ColonDescendens_bc" />
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="Aef3-r-C-EWRA75PTl7XbA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="T24phj_cCkexYh6X30N2MQ" name="Mass transfer rate (intestine to mucosa blood cells)" description="Mass transfer rate (intestine to mucosa blood cells)" persistable="0" isFixedValue="0" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaBloodCells" dim="Rate" quantityType="0" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="4sYj-uA8NkSIPnqiWzWH7w" name="LargeIntestine_pls_ColonDescendens_pls" description="Neighborhood between Large Intestine/Plasma_ and Colon Descendens/Plasma" mode="Logical" containerType="Other" firstNeighbor="KnL-t0swKEGlt4XXJPF8sA" secondNeighbor="z4zcH_HhW0yr4B9Cwg_sfw">
-            <Tags>
-              <Tag value="LargeIntestine_pls_ColonDescendens_pls" />
-              <Tag value="Neighborhood: Plasma / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="qsQLRJiu00Oy1695JF-Nyw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="DVo6b9yxGk2ZwnQ0R15Uvg" name="Mass transfer rate (intestine to mucosa plasma)" description="Mass transfer rate (intestine to mucosa plasma)" persistable="0" isFixedValue="0" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaPlasma" dim="Rate" quantityType="0" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="x0YjGi59pEWZpMJGD5mVQA" name="LargeIntestine_pls_ColonTransversum_pls" description="Neighborhood between Large Intestine/Plasma_ and Colon Transversum/Plasma" mode="Logical" containerType="Other" firstNeighbor="KnL-t0swKEGlt4XXJPF8sA" secondNeighbor="iPvRkWZ76UCcWPzFPJlJxQ">
-            <Tags>
-              <Tag value="LargeIntestine_pls_ColonTransversum_pls" />
-              <Tag value="Neighborhood: Plasma / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="Yy94I7tWBE2rZ3K66Lx72w" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="QLwmH84NH0KPJKf86g4qlw" name="Mass transfer rate (intestine to mucosa plasma)" description="Mass transfer rate (intestine to mucosa plasma)" persistable="0" isFixedValue="0" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaPlasma" dim="Rate" quantityType="0" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="cl5eeVOPBEiSicgiVPwG5g" name="LargeIntestine_bc_ColonAscendens_bc" description="Neighborhood between Large Intestine/Blood Cells_ and Colon Ascendens/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="4VlXh1FvuEi4iThCgPo84g" secondNeighbor="61Zi-_Bk6k2KAceYwRaXCw">
-            <Tags>
-              <Tag value="LargeIntestine_bc_ColonAscendens_bc" />
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="UIArd9rSI0mdK2yS7A3cjA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="juJtXaF69U24NdMUqk-uKw" name="Mass transfer rate (intestine to mucosa blood cells)" description="Mass transfer rate (intestine to mucosa blood cells)" persistable="0" isFixedValue="0" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaBloodCells" dim="Rate" quantityType="0" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="aLnQ1hfgyU-lGnAmRAelhQ" name="LargeIntestine_pls_ColonAscendens_pls" description="Neighborhood between Large Intestine/Plasma_ and Colon Ascendens/Plasma" mode="Logical" containerType="Other" firstNeighbor="KnL-t0swKEGlt4XXJPF8sA" secondNeighbor="lD1ALP8VY0eUEmlEri8jWA">
-            <Tags>
-              <Tag value="LargeIntestine_pls_ColonAscendens_pls" />
-              <Tag value="Neighborhood: Plasma / Plasma" />
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-            <Children>
-              <Container id="SM-SgX8P2kSY9Co3_UYoTQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="8Vf01urLdkeTRrADHINfbg" name="Mass transfer rate (intestine to mucosa plasma)" description="Mass transfer rate (intestine to mucosa plasma)" persistable="0" isFixedValue="0" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaPlasma" dim="Rate" quantityType="0" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="LcjwYR0t1UWbzlOYDoSWTg" name="LargeIntestine_bc_Caecum_bc" description="Neighborhood between Large Intestine/Blood Cells_ and Cecum/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="4VlXh1FvuEi4iThCgPo84g" secondNeighbor="b6vJ67uVlUGBdmnT37TEDw">
-            <Tags>
-              <Tag value="LargeIntestine_bc_Caecum_bc" />
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="3D0caNeTqUOfI-ZK4OUtPA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="55KqkDxpPkqiX_2IZjylcg" name="Mass transfer rate (intestine to mucosa blood cells)" description="Mass transfer rate (intestine to mucosa blood cells)" persistable="0" isFixedValue="0" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaBloodCells" dim="Rate" quantityType="0" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="TKogpHf0OEKre4JZ5__n0Q" name="LargeIntestine_pls_Caecum_pls" description="Neighborhood between Large Intestine/Plasma_ and Cecum/Plasma" mode="Logical" containerType="Other" firstNeighbor="KnL-t0swKEGlt4XXJPF8sA" secondNeighbor="CKUV4Ze6d0eoYQnRGiicug">
-            <Tags>
-              <Tag value="LargeIntestine_pls_Caecum_pls" />
-              <Tag value="Neighborhood: Plasma / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="ub1cObwXb0yU2OtU6aoVRQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="KsPMJ_GOn0atpg4XaHVMHw" name="Mass transfer rate (intestine to mucosa plasma)" description="Mass transfer rate (intestine to mucosa plasma)" persistable="0" isFixedValue="0" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaPlasma" dim="Rate" quantityType="0" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="w-jUowHSMECpkzBP2eQdxQ" name="LargeIntestine_bc_ColonTransversum_bc" description="Neighborhood between Large Intestine/Blood Cells_ and Colon Transversum/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="4VlXh1FvuEi4iThCgPo84g" secondNeighbor="k3eDZxhGcUSx99US8MzGjg">
-            <Tags>
-              <Tag value="LargeIntestine_bc_ColonTransversum_bc" />
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="FSW64JKfIEW14Xn6fGfUMA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="Sn3tRDr34UKFLMdWRdJEFg" name="Mass transfer rate (intestine to mucosa blood cells)" description="Mass transfer rate (intestine to mucosa blood cells)" persistable="0" isFixedValue="0" formula="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaBloodCells" dim="Rate" quantityType="0" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="kjV7PwxRtkGdAQ612CaR5A" name="LargeIntestine_bc_PortalVein_bc" description="Neighborhood between Large Intestine/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="4VlXh1FvuEi4iThCgPo84g" secondNeighbor="f1NQXRLB-0m-az7rPFpZXw">
-            <Tags>
-              <Tag value="LargeIntestine_bc_PortalVein_bc" />
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="xur9tAJihEul96EnfcBn3w" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="4lhpQImF10yUAVMUrK8Rrw" name="LargeIntestine_pls_PortalVein_pls" description="Neighborhood between Large Intestine/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="KnL-t0swKEGlt4XXJPF8sA" secondNeighbor="w0IqwDHp6UGv317_8RFz7w">
-            <Tags>
-              <Tag value="LargeIntestine_pls_PortalVein_pls" />
-              <Tag value="Neighborhood: Plasma / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="9uyIIgB7vkioHJ81WG6JOA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="QsGgKrTDBkCMOxOhZh2DDg" name="LargeIntestine_pls_LargeIntestine_int" description="Neighborhood between Large Intestine/Plasma and Large Intestine/Interstitial" mode="Logical" containerType="Other" firstNeighbor="KnL-t0swKEGlt4XXJPF8sA" secondNeighbor="aKhkW1Ped0KharW9yTH8kQ">
-            <Tags>
-              <Tag value="LargeIntestine_pls_LargeIntestine_int" />
-              <Tag value="Large intestine  neighborhood" />
-              <Tag value="Neighborhood: Plasma / Interstitial" />
-            </Tags>
-            <Children>
-              <Container id="VOwevrJEDk-AmPJJvmxU6A" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="m2PFsZHTikCeskXhy9xbLA" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" formula="4EV9_t1cc0Cib6dGES1GwA" dim="Velocity" quantityType="0" />
-                  <Parameter id="1xdhtVbVHUC5crucUYEvIg" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" dim="Dimensionless" quantityType="0" />
-                </Children>
-              </Container>
-              <Parameter id="LVh3VJxzzESc7UG-KQNkig" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int_sinlin" dim="Surface" quantityType="0" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="_YI56orKQ0-CqZbbqHQXag" name="LargeIntestine_pls_LargeIntestine_bc" description="Neighborhood between Large Intestine/Plasma and Large Intestine/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="KnL-t0swKEGlt4XXJPF8sA" secondNeighbor="4VlXh1FvuEi4iThCgPo84g">
-            <Tags>
-              <Tag value="LargeIntestine_pls_LargeIntestine_bc" />
-              <Tag value="Large intestine  neighborhood" />
-              <Tag value="Neighborhood: Plasma / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="R6uiwQVB40mxbRCx_vYy0w" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              <Parameter id="2KuzbZP-i0aK5kmpWGTZfA" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls_sinlin" dim="Surface" quantityType="0" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="MJFCzK5-_Uur_Le9mA21qQ" name="LargeIntestine_int_LargeIntestine_cell" description="Neighborhood between Large Intestine/Interstitial and Large Intestine/Intracellular" mode="Logical" containerType="Other" firstNeighbor="aKhkW1Ped0KharW9yTH8kQ" secondNeighbor="kUScFceMJk2wTz5XwgEvTQ">
-            <Tags>
-              <Tag value="LargeIntestine_int_LargeIntestine_cell" />
-              <Tag value="Large intestine  neighborhood" />
-              <Tag value="Neighborhood: Interstitial / Intracellular" />
-            </Tags>
-            <Children>
-              <Container id="C189iHlJD0mfxpaDVWqicQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="kFZWlG-JqUyLM8poq4NP2g" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" dim="Velocity" quantityType="0" />
-                  <Parameter id="y4SJiuNW7kyzqNxVll3hkw" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" dim="Velocity" quantityType="0" />
-                  <Parameter id="2dnIAHlOaEm0BPgtX7D0gw" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" dim="Flow (volume)" quantityType="0" />
-                  <Parameter id="C9wn2CSF6UmcMn7xijlzFA" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" dim="Flow (volume)" quantityType="0" />
-                  <Parameter id="Kh8NzL--bE-RysRNMsZCNw" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="swDWL_T9xEqQnEFYXeyLkw" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="nrdoT-Vb0kWw9-lzNTr1BA" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="203gvUjDl0mkm2hLSkN4Kg" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" dim="Dimensionless" quantityType="0" />
-                </Children>
-              </Container>
-              <Parameter id="W918rl3S6kGyQzr1NFDQqw" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_lin" dim="Surface" quantityType="0" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="Hxl6XxWc-UKbR07_JZzHlA" name="Liver_cell_Gallbladder" description="Neighborhood between Liver/Intracellular and Gallbladder" mode="Logical" containerType="Other" firstNeighbor="isrXizHu7E-JR92xn5ckRg" secondNeighbor="R3nOYl7_VU62l9QCspJwVA">
-            <Tags>
-              <Tag value="Liver_cell_Gallbladder" />
-              <Tag value="Neighborhood: Intracellular / Gallbladder" />
-            </Tags>
-            <Children>
-              <Container id="sX9ODMQ7REWRb3R3wjl2XQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="1XpzAdRTYEeVkQq8o2F4DA" name="Liver_pls_Liver_bc" description="Neighborhood between Liver/Plasma and Liver/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="tyWN5KXnjESqo6psq7MKGg" secondNeighbor="XysqfO-qtUmc2ATdlw_i7w">
-            <Tags>
-              <Tag value="Liver_pls_Liver_bc" />
-              <Tag value="Neighborhood: Plasma / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="kk7PYbGaXE-ABUFBFEGzZA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              <Parameter id="CamoymoKb0qs4nUeYGon6g" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" dim="Surface" quantityType="0" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="KeAZXg-cA0ij4naTpSzxIA" name="Liver_bc_VenousBlood_bc" description="Neighborhood between Liver/Blood Cells and Venous Blood/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="XysqfO-qtUmc2ATdlw_i7w" secondNeighbor="td5KxHkAVkiuQetPlAwgVQ">
-            <Tags>
-              <Tag value="Liver_bc_VenousBlood_bc" />
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="y0LQRzt9rU-Au12ZncyJtw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="LN4cxdVebU-KFu_camoNSw" name="Liver_pls_Liver_int" description="Neighborhood between Liver/Plasma and Liver/Interstitial" mode="Logical" containerType="Other" firstNeighbor="tyWN5KXnjESqo6psq7MKGg" secondNeighbor="XC-kBHkNoE-6hvHY_lkMug">
-            <Tags>
-              <Tag value="Liver_pls_Liver_int" />
-              <Tag value="Neighborhood: Plasma / Interstitial" />
-            </Tags>
-            <Children>
-              <Container id="hlvA_CS4bEOXfCiThoOMHQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="bo2z9xKkwkGUWKCWPka3XA" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="9GEgQ9A-MkCE8wTpnXWoUA" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" formula="ZGh8fCj8eUeC2oLu-qxlrQ" dim="Velocity" quantityType="0" />
-                </Children>
-              </Container>
-              <Parameter id="xzInfe7paU-JLnm6h0Y0cw" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" dim="Surface" quantityType="0" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="8P0UnFKlP0SqYJaI6rPTnw" name="Liver_pls_VenousBlood_pls" description="Neighborhood between Liver/Plasma and Venous Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="tyWN5KXnjESqo6psq7MKGg" secondNeighbor="j2n6uKMQM0uCZWZ--9NUbg">
-            <Tags>
-              <Tag value="Liver_pls_VenousBlood_pls" />
-              <Tag value="Neighborhood: Plasma / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="nkEUVVkULEWShRRb6Dpo9Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="aqF1fj-6_E62-bD-QvQuSg" name="Liver_int_Liver_cell" description="Neighborhood between Liver/Interstitial and Liver/Intracellular" mode="Logical" containerType="Other" firstNeighbor="XC-kBHkNoE-6hvHY_lkMug" secondNeighbor="isrXizHu7E-JR92xn5ckRg">
-            <Tags>
-              <Tag value="Liver_int_Liver_cell" />
-              <Tag value="Neighborhood: Interstitial / Intracellular" />
-            </Tags>
-            <Children>
-              <Container id="N8akRq5GsUO-gegAjgG2-g" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="37X9v9ZlZUyO6drImhzswQ" name="Min (PA, Q)" description="Minimum between permeability and blood flow" persistable="0" isFixedValue="0" formula="PlasmaClearance_PKSim.PARAM_min_PA_Q" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="gcVr34gJkEKLY5qONInfAw" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" dim="Velocity" quantityType="0" />
-                  <Parameter id="epzEjmSkdUOTztfWZgHzwA" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" dim="Velocity" quantityType="0" />
-                  <Parameter id="qZvWZ6kls0KjQtnzvd-p_Q" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" dim="Flow (volume)" quantityType="0" />
-                  <Parameter id="JOOhA2oB8keRQ2dYbCotvw" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" dim="Flow (volume)" quantityType="0" />
-                  <Parameter id="FGF49qbVbUG-_s_VmUwCAg" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="n28Q9aSZC0u-Y8gM38aznQ" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="Z_5Xv6gTlkmivaaT8bqhGg" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="OFt3XMOwhEySAYx2YOSebw" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" dim="Dimensionless" quantityType="0" />
-                </Children>
-              </Container>
-              <Parameter id="rzFTVttqB0Oe_l2TAgcYAA" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_liv" dim="Surface" quantityType="0" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="oePJTqErJ0i8fOAxygm9ag" name="Gallbladder_Lumen_duo" description="Gallbladder and Lumen/Duodenum" mode="Logical" containerType="Other" firstNeighbor="R3nOYl7_VU62l9QCspJwVA" secondNeighbor="0GDB2v61NEaYOE7qtRF98A">
-            <Tags>
-              <Tag value="Gallbladder_Lumen_duo" />
-              <Tag value="Neighborhood: Gallbladder / Duodenum" />
-            </Tags>
-            <Children>
-              <Container id="t5jdKt8HS0yYIJI8yhG_xA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="c4KEOHSkVkaaRLH_DkIWlw" name="Liver_cell_Lumen_duo" description="Neighborhood between Liver/Intracellular and Lumen/Duodenum" mode="Logical" containerType="Other" firstNeighbor="isrXizHu7E-JR92xn5ckRg" secondNeighbor="0GDB2v61NEaYOE7qtRF98A">
-            <Tags>
-              <Tag value="Liver_cell_Lumen_duo" />
-              <Tag value="Neighborhood: Intracellular / Duodenum" />
-            </Tags>
-            <Children>
-              <Container id="8-TkMgWPmUCS1WhsJBaCEA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="Lv3BZAirYUWZDsPHokcziw" name="Lung_bc_ArterialBlood_bc" description="Neighborhood between Lung/Blood Cells and Arterial Blood/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="8Hxc0s3ANEWMmGloh6Tvcg" secondNeighbor="Q5cCzzKlnke4qkHZ8xor5Q">
-            <Tags>
-              <Tag value="Lung_bc_ArterialBlood_bc" />
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="MjT9tL9n2UOfRIGDTIgNZw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="T_G7AuGl-0-TT0xzkUFFCQ" name="Lung_pls_ArterialBlood_pls" description="Neighborhood between Lung/Plasma and Arterial Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="WCwWAQPlBEiu2DPVUYG1Zg" secondNeighbor="CcmyB0FGkEKvncpso4EAvQ">
-            <Tags>
-              <Tag value="Lung_pls_ArterialBlood_pls" />
-              <Tag value="Neighborhood: Plasma / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="F3L3y_AYWEG7cyKbrLS6Zg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="VJW4MTMO7Um6Zlcl3urNhg" name="Lung_pls_Lung_bc" description="Neighborhood between Lung/Plasma and Lung/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="WCwWAQPlBEiu2DPVUYG1Zg" secondNeighbor="8Hxc0s3ANEWMmGloh6Tvcg">
-            <Tags>
-              <Tag value="Lung_pls_Lung_bc" />
-              <Tag value="Neighborhood: Plasma / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="N72vngBWiUqQEpPqbsctmg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              <Parameter id="oZ18oE09OUiwXSLu42Hplg" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" dim="Surface" quantityType="0" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="7Dcn4iKh30qxgRMJZBqxFQ" name="Lung_pls_Lung_int" description="Neighborhood between Lung/Plasma and Lung/Interstitial" mode="Logical" containerType="Other" firstNeighbor="WCwWAQPlBEiu2DPVUYG1Zg" secondNeighbor="vy0-0MwNqkSeHPIm4MJFRQ">
-            <Tags>
-              <Tag value="Lung_pls_Lung_int" />
-              <Tag value="Neighborhood: Plasma / Interstitial" />
-            </Tags>
-            <Children>
-              <Container id="e3zM4t2Jrke9xli6P8CncQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="9MjI9J6zZEqbcsbaTR6bWQ" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" formula="UYZiOtbMMkG3fOFqkIxOQg" dim="Velocity" quantityType="0" />
-                  <Parameter id="BN3h0UBN60aOtgXc5gwqxw" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" dim="Dimensionless" quantityType="0" />
-                </Children>
-              </Container>
-              <Parameter id="k0V6fDs-dU-HlFQisMLzIw" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" dim="Surface" quantityType="0" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="z4KqzRfmU0Kh96obAmbZ2A" name="Lung_int_Lung_cell" description="Neighborhood between Lung/Interstitial and Lung/Intracellular" mode="Logical" containerType="Other" firstNeighbor="vy0-0MwNqkSeHPIm4MJFRQ" secondNeighbor="ui-P-36aJEiMnjRMP4Nx2g">
-            <Tags>
-              <Tag value="Lung_int_Lung_cell" />
-              <Tag value="Neighborhood: Interstitial / Intracellular" />
-            </Tags>
-            <Children>
-              <Container id="-MX2YZL48Uqd6403ocCoyQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="5oe_knSMH0qexuaMT7CPHA" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="BfRhkw-RukOFeJBQNn6YrA" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="x82qxkFcX0CIu0yk8OHGxQ" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="kaILVgre0EGG83kB9aNUhw" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="C9W1y9LYmUisrWVBrOqGmQ" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" dim="Velocity" quantityType="0" />
-                  <Parameter id="5FSFvqvaAUal0-1Psu3BhA" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" dim="Flow (volume)" quantityType="0" />
-                  <Parameter id="_Hk5OY--EkKvoFsQjiuPYw" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" dim="Flow (volume)" quantityType="0" />
-                  <Parameter id="oF-2spzZt0SXHGIpNdvqYg" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" dim="Velocity" quantityType="0" />
-                </Children>
-              </Container>
-              <Parameter id="_KtkzVwr4E-KtTl8DEeFMw" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_lng" dim="Surface" quantityType="0" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="J7YJ91h0IUu28W1HXfLs3w" name="Muscle_int_Muscle_cell" description="Neighborhood between Muscle/Interstitial and Muscle/Intracellular" mode="Logical" containerType="Other" firstNeighbor="JaBSUUCDD06oopTalTFBLA" secondNeighbor="80SRRXbsyUWeN3fS1NqrUA">
-            <Tags>
-              <Tag value="Muscle_int_Muscle_cell" />
-              <Tag value="Neighborhood: Interstitial / Intracellular" />
-            </Tags>
-            <Children>
-              <Container id="5hVw_uyeWk-iUHAC-bQiKA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="r9t1gNOsi0KYP7c-z0FF-Q" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="tMMQ21IHeEyNIPtIOHdT8g" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" dim="Velocity" quantityType="0" />
-                  <Parameter id="5UtfZ2bdUEGmyDlvghS1nA" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" dim="Velocity" quantityType="0" />
-                  <Parameter id="WdYjtef0r0WtK2SJU1gf-A" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" dim="Flow (volume)" quantityType="0" />
-                  <Parameter id="GFDfCElNYEmiweJSd35waw" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="Lpuc6_7pfEOP00zcWc8tmg" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" dim="Flow (volume)" quantityType="0" />
-                  <Parameter id="dTM5M-EbkEylULAoWT6Ggg" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="l9fOohJcA0-txhqNkdJbnA" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" dim="Dimensionless" quantityType="0" />
-                </Children>
-              </Container>
-              <Parameter id="9Uev_dWjsU-Zzd93TjgNHg" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mus" dim="Surface" quantityType="0" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="CEhVuM2Ac0ykXnA9z76oDQ" name="Muscle_pls_Muscle_bc" description="Neighborhood between Muscle/Plasma and Muscle/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="GC636Tx7uE61b65qVROxZA" secondNeighbor="eK9VyfeChkylRBoB9HqkvQ">
-            <Tags>
-              <Tag value="Muscle_pls_Muscle_bc" />
-              <Tag value="Neighborhood: Plasma / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="iWptVyXuzU-o2mSYs4FIWw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              <Parameter id="MJ8JaiW6Y0iJ4CEWJK4a-A" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" dim="Surface" quantityType="0" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="VFQ8sG0g3UGGdlMk5biBgQ" name="Muscle_pls_VenousBlood_pls" description="Neighborhood between Muscle/Plasma and Venous Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="GC636Tx7uE61b65qVROxZA" secondNeighbor="j2n6uKMQM0uCZWZ--9NUbg">
-            <Tags>
-              <Tag value="Muscle_pls_VenousBlood_pls" />
-              <Tag value="Neighborhood: Plasma / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="AFOuOEoVtk-GPueOMjAk5Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="xPQwFLsDz0KKUKiRndw5Tg" name="Muscle_pls_Muscle_int" description="Neighborhood between Muscle/Plasma and Muscle/Interstitial" mode="Logical" containerType="Other" firstNeighbor="GC636Tx7uE61b65qVROxZA" secondNeighbor="JaBSUUCDD06oopTalTFBLA">
-            <Tags>
-              <Tag value="Muscle_pls_Muscle_int" />
-              <Tag value="Neighborhood: Plasma / Interstitial" />
-            </Tags>
-            <Children>
-              <Container id="huLpKIrZDUSgI9mWQyLmiQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="qRjNAkf5OU-g4DXpPzmSpA" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" formula="aaLJSrFj80im_nAsnJJ4rw" dim="Velocity" quantityType="0" />
-                  <Parameter id="LxSI9AWYgkmdX4tCNBQt2w" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" dim="Dimensionless" quantityType="0" />
-                </Children>
-              </Container>
-              <Parameter id="n9Q6JAWZFEOlTAtannOnfQ" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" dim="Surface" quantityType="0" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="O8lPWxGTsku2JSpQjS3Sog" name="Muscle_bc_VenousBlood_bc" description="Neighborhood between Muscle/Blood Cells and Venous Blood/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="eK9VyfeChkylRBoB9HqkvQ" secondNeighbor="td5KxHkAVkiuQetPlAwgVQ">
-            <Tags>
-              <Tag value="Muscle_bc_VenousBlood_bc" />
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="TCDyWy5kwESmvRsSvATYRA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="ZEqbt90Q1EGqt8j9xP2JSw" name="Pancreas_bc_PortalVein_bc" description="Neighborhood between Pancreas/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="rqg-Om2JMU-ELUIO56tN4w" secondNeighbor="f1NQXRLB-0m-az7rPFpZXw">
-            <Tags>
-              <Tag value="Pancreas_bc_PortalVein_bc" />
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="M7tSU3hRqUSHYhQZxsFDmw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="UbYx5cYGYEqnWXOpquO8mA" name="Pancreas_pls_PortalVein_pls" description="Neighborhood between Pancreas/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="qaSDqw_STUiUKqcQ2q2fbQ" secondNeighbor="w0IqwDHp6UGv317_8RFz7w">
-            <Tags>
-              <Tag value="Pancreas_pls_PortalVein_pls" />
-              <Tag value="Neighborhood: Plasma / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="DPMc4Xn1cUC7KcDx9xYMVA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="3CEy8FBSbEyxtMbO4XVFdA" name="Pancreas_pls_Pancreas_int" description="Neighborhood between Pancreas/Plasma and Pancreas/Interstitial" mode="Logical" containerType="Other" firstNeighbor="qaSDqw_STUiUKqcQ2q2fbQ" secondNeighbor="_-P7kL13fU6q9uvAPmHqGg">
-            <Tags>
-              <Tag value="Pancreas_pls_Pancreas_int" />
-              <Tag value="Neighborhood: Plasma / Interstitial" />
-            </Tags>
-            <Children>
-              <Container id="a8GUBy6CqE6OV88WUo_GqQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="2OQIGDdaqEOHSFvgW0csOg" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" formula="rH6G-yLAk0qtu4M7pUQyCQ" dim="Velocity" quantityType="0" />
-                  <Parameter id="0wBZZj8dnEW-9SoIHanXog" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" dim="Dimensionless" quantityType="0" />
-                </Children>
-              </Container>
-              <Parameter id="bt6_CvLtsEeWQeRvPlTs9A" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" dim="Surface" quantityType="0" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="SYDuA4SCCUO3s773cK0MJg" name="Pancreas_pls_Pancreas_bc" description="Neighborhood between Pancreas/Plasma and Pancreas/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="qaSDqw_STUiUKqcQ2q2fbQ" secondNeighbor="rqg-Om2JMU-ELUIO56tN4w">
-            <Tags>
-              <Tag value="Pancreas_pls_Pancreas_bc" />
-              <Tag value="Neighborhood: Plasma / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="7jKjlUE6-0WqtmkVNLYu6Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              <Parameter id="RL9kNsEHh0-ddv5cQznAfg" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" dim="Surface" quantityType="0" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="1OPcR0Ygl0qnLATvmchguQ" name="Pancreas_int_Pancreas_cell" description="Neighborhood between Pancreas/Interstitial and Pancreas/Intracellular" mode="Logical" containerType="Other" firstNeighbor="_-P7kL13fU6q9uvAPmHqGg" secondNeighbor="jIlAfjg-CUSGghK47lyr2w">
-            <Tags>
-              <Tag value="Pancreas_int_Pancreas_cell" />
-              <Tag value="Neighborhood: Interstitial / Intracellular" />
-            </Tags>
-            <Children>
-              <Container id="mislfgA8F0mhbUanadXcYg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="kfsuUl6zYUmfScBGxURgGQ" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="4F6j2GuHTk265KeKWjMl_w" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="k9NaRSULbEKWQasjYeeC7w" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" dim="Velocity" quantityType="0" />
-                  <Parameter id="zUMFb5p-n0-NANcDODg9JA" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" dim="Velocity" quantityType="0" />
-                  <Parameter id="4MAZ8vCQMEaAPREB1bqjyw" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" dim="Flow (volume)" quantityType="0" />
-                  <Parameter id="Q-3PTu0CkkuuxGIOYgw_Eg" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" dim="Flow (volume)" quantityType="0" />
-                  <Parameter id="xmKSd-st20mJRG3ZoHbsnQ" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="2GS7hXSuZ0yDz3yFREnONA" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" dim="Dimensionless" quantityType="0" />
-                </Children>
-              </Container>
-              <Parameter id="8gAr36JbLUGtMz-g3Qfqfw" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_pan" dim="Surface" quantityType="0" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="Y24Gzd1vsk-_Rvyz2Znz6g" name="Lumen_rect_Rectum_cell" description="Neighborhood between Lumen/Rectum and Mucosa/Rectum/Intracellular" mode="Logical" containerType="Other" firstNeighbor="BSo2lLHrCkGHE23rSU5SRw" secondNeighbor="QsQ9xRaAm0yGNxNTxJ3PuA">
-            <Tags>
-              <Tag value="Lumen_rect_Rectum_cell" />
-              <Tag value="Neighborhood: Rectum / Intracellular" />
-            </Tags>
-            <Children>
-              <Container id="It9V9APcUEaSXxj31tR6JQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="3gxtBNzeVk67kR4frgeiTQ" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F2" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="O5HxEXb5eEeXXeMR04U2Ag" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K8" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="UJvOnCLvA0iLZEZgd649MQ" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K7" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="cSzftRJXLUWd5stkNAXG-w" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K6" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="W9Z6c1yYQkC_42emaWEuhg" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K5" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="VivXrs2CTEGfApowAcRaEw" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K4" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="QaOfbZneV0i90sV1FToaSw" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K3" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="l4EafuCPzUGEB8H63o_Rmw" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K2" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="zxKKPp0xFkKPvIvlTAkEPg" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F3" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="SFxtCeN1hkK9yGZI1saCUQ" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F1" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="6IGpgNoe-0GafwmVC1x_Rg" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K8" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="0ZBtpaXcl06scClwZ54saQ" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K7" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="6yBaktl8c0mbAFmQuJf8Ow" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K6" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="wMZN4MZ7gUKwzkIq621RZQ" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K5" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="BSL9bzCj7kKuqJe8UTlJrg" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K4" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="_PpRs5-3aUa1iLNouM0omg" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K3" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="al2essMWD0mGDfvHK6da0A" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K2" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="2uX2ZDzCHkuDfJ9pTdmXrQ" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K1" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="uFRP0WXTxk-rRGzyhCsy1A" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F3" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="d6Ft-aGejE-jqJN6nzw1YA" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F2" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="3olZsyl1ckO21CPRrnR6lg" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F1" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="Rux-A1RvHEGJhJci6kq_tA" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K1" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="lBLz78-mLUK012hATsdRhQ" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_lum_cell_factor" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="USQyemzC1kGse1hAaDHclQ" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_Rectum" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="CaSibeZpr0OMtefyJnBS9w" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_cell_lum_factor" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="ERdLsh-fdkiaisIG5DgQmw" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_DrugAbsorption_trans" dim="Rate" quantityType="0" />
-                  <Parameter id="rzAPVorYpEOsBMLJZLjsOA" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_K_cell_pls_Rectum" dim="Dimensionless" quantityType="0" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="O4qlqgJLL022LwThdaI7RQ" name="Rectum_bc_PortalVein_bc" description="Neighborhood between Rectum/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="udxtFKMRFUe0Mj2-C-W3hg" secondNeighbor="f1NQXRLB-0m-az7rPFpZXw">
-            <Tags>
-              <Tag value="Rectum_bc_PortalVein_bc" />
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="uZ59QfFL9kCrlBTp6dkHuw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="62TQg9ZXEkiAZDHuW-Xc-A" name="Mass transfer rate (mucosa to portal vein blood cells)" description="Mass transfer rate (mucosa to portal vein blood cells)" persistable="0" isFixedValue="0" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPveBloodCells" dim="Rate" quantityType="0" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="xadCEIAUBEGP_l0nxsn7AA" name="Rectum_pls_PortalVein_pls" description="Neighborhood between Rectum/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="eJzNOCYba06diGWhCWqi1Q" secondNeighbor="w0IqwDHp6UGv317_8RFz7w">
-            <Tags>
-              <Tag value="Rectum_pls_PortalVein_pls" />
-              <Tag value="Neighborhood: Plasma / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="XYS4o1hww0SB_ZkX6ttg6Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="HoEAjO6vUUORYMQ9hfdEyg" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" persistable="0" isFixedValue="0" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPvePlasma" dim="Rate" quantityType="0" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="oi8tq_ngDkyTSzJCv78tNA" name="Lumen_rect_Rectum_pls" description="Neighborhood between Lumen/Rectum and Mucosa/Rectum/Plasma" mode="Logical" containerType="Other" firstNeighbor="BSo2lLHrCkGHE23rSU5SRw" secondNeighbor="eJzNOCYba06diGWhCWqi1Q">
-            <Tags>
-              <Tag value="Lumen_rect_Rectum_pls" />
-              <Tag value="Neighborhood: Rectum / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="7Gt1s4X_l0in690kQ7UFKA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="dF2kMwk-pkmrUHzZX5ApuA" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_DrugAbsorption_para" dim="Rate" quantityType="0" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="CMzrx_KUAEiShPI75Epy-A" name="PortalVein_pls_PortalVein_bc" description="Neighborhood between PortalVein/Plasma and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="w0IqwDHp6UGv317_8RFz7w" secondNeighbor="f1NQXRLB-0m-az7rPFpZXw">
-            <Tags>
-              <Tag value="PortalVein_pls_PortalVein_bc" />
-              <Tag value="Neighborhood: Plasma / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="wWkusxiCMkGP5-TBZ89-2g" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              <Parameter id="3v91jenk0kCMP58rx5v4eQ" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls_Blood_Organ" dim="Surface" quantityType="0" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="vuJgpyk53kaHBzu2gMISfA" name="PortalVein_bc_Liver_bc" description="Neighborhood between PortalVein/Blood Cells and Liver/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="f1NQXRLB-0m-az7rPFpZXw" secondNeighbor="XysqfO-qtUmc2ATdlw_i7w">
-            <Tags>
-              <Tag value="PortalVein_bc_Liver_bc" />
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="3OIPbLxZi0a3xhbbx45mHA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="BWWkxeJdj0SBXxyzW6BVeA" name="PortalVein_pls_Liver_pls" description="Neighborhood between PortalVein/Plasma and Liver/Plasma" mode="Logical" containerType="Other" firstNeighbor="w0IqwDHp6UGv317_8RFz7w" secondNeighbor="tyWN5KXnjESqo6psq7MKGg">
-            <Tags>
-              <Tag value="PortalVein_pls_Liver_pls" />
-              <Tag value="Neighborhood: Plasma / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="BzwZnXszE0mA2ijcnmC0Cg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="hNgGz3Oha0u8_5FP_TYMpQ" name="Skin_pls_Skin_bc" description="Neighborhood between Skin/Plasma and Skin/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="G6h-cYh_e0yFknyXZd5Mwg" secondNeighbor="qvC9N1AfkEK8pOJosYCAXA">
-            <Tags>
-              <Tag value="Skin_pls_Skin_bc" />
-              <Tag value="Neighborhood: Plasma / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="41aCA5pLHUCQyb1ol00DSA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              <Parameter id="W1FCUUOiNEGAXEXaJXp9hQ" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" dim="Surface" quantityType="0" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="Vbuuodtd5E-ipQMjuUexNg" name="Skin_int_Skin_cell" description="Neighborhood between Skin/Interstitial and Skin/Intracellular" mode="Logical" containerType="Other" firstNeighbor="Kn-rrzRbwk2lP_Bz0Q8xBw" secondNeighbor="3hWpFFMIdUONNmNyctMGVQ">
-            <Tags>
-              <Tag value="Skin_int_Skin_cell" />
-              <Tag value="Neighborhood: Interstitial / Intracellular" />
-            </Tags>
-            <Children>
-              <Container id="Ah7n2BQ3p0-9Ng8rBY1pFg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="fNUa_wB-nk-lc9ut5HQU1w" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="j6qgMqWkSUuFbDdBlshZQw" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" dim="Velocity" quantityType="0" />
-                  <Parameter id="Zlnff_JuXEyetli0125CBQ" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" dim="Velocity" quantityType="0" />
-                  <Parameter id="IhV3sC7MnUWnqZTfrzYpwQ" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" dim="Flow (volume)" quantityType="0" />
-                  <Parameter id="3wH8gxeuG0S36TantT9HFA" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" dim="Flow (volume)" quantityType="0" />
-                  <Parameter id="Pbv6tZQrDEymSYMKXm8UrA" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="zMnvEe5kq0W2OuNw8FCIIw" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="mH4wbVHu-0KK1xOcKLY5Sw" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" dim="Dimensionless" quantityType="0" />
-                </Children>
-              </Container>
-              <Parameter id="5APQ0IxsEkynGchj5dzUVQ" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_skn" dim="Surface" quantityType="0" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="P9mM4wxN_Ei6urpGDcEg0Q" name="Skin_bc_VenousBlood_bc" description="Neighborhood between Skin/Blood Cells and Venous Blood/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="qvC9N1AfkEK8pOJosYCAXA" secondNeighbor="td5KxHkAVkiuQetPlAwgVQ">
-            <Tags>
-              <Tag value="Skin_bc_VenousBlood_bc" />
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="JVej5pQq402iYXs0AZCHeA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="3YFKhiouuUmqDswbOq5Gvg" name="Skin_pls_Skin_int" description="Neighborhood between Skin/Plasma and Skin/Interstitial" mode="Logical" containerType="Other" firstNeighbor="G6h-cYh_e0yFknyXZd5Mwg" secondNeighbor="Kn-rrzRbwk2lP_Bz0Q8xBw">
-            <Tags>
-              <Tag value="Skin_pls_Skin_int" />
-              <Tag value="Neighborhood: Plasma / Interstitial" />
-            </Tags>
-            <Children>
-              <Container id="bBTgD3mzGUS60nXcWolRsg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="H0kaOV4WrUG5f2JHTv5h-g" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" formula="B1M0qUn2S0yXWQmRc1pTfg" dim="Velocity" quantityType="0" />
-                  <Parameter id="mLByep3ka0CYS5ekay97EA" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" dim="Dimensionless" quantityType="0" />
-                </Children>
-              </Container>
-              <Parameter id="jEBwkdC1kUKEG4WfhVlFTQ" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" dim="Surface" quantityType="0" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="75PJYXlicUS2JbDinhzElg" name="Skin_pls_VenousBlood_pls" description="Neighborhood between Skin/Plasma and Venous Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="G6h-cYh_e0yFknyXZd5Mwg" secondNeighbor="j2n6uKMQM0uCZWZ--9NUbg">
-            <Tags>
-              <Tag value="Skin_pls_VenousBlood_pls" />
-              <Tag value="Neighborhood: Plasma / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="l1QXf2AJ4EOeZVGpEEoXwg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="Rcix3ULvZUKXiFU0gGWbBw" name="Spleen_bc_PortalVein_bc" description="Neighborhood between Spleen/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="kHaRuNvhZU2sFR-n9sC5oQ" secondNeighbor="f1NQXRLB-0m-az7rPFpZXw">
-            <Tags>
-              <Tag value="Spleen_bc_PortalVein_bc" />
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="HF0bQPhFGUWEfXYeAxsETg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="64fUme6beUWYfpV4I96TGg" name="Spleen_int_Spleen_cell" description="Neighborhood between Spleen/Interstitial and Spleen/Intracellular" mode="Logical" containerType="Other" firstNeighbor="wBcGoQrNPkmc-L9H-rAxeQ" secondNeighbor="WWc5qJwmekWeZ-35762U1Q">
-            <Tags>
-              <Tag value="Spleen_int_Spleen_cell" />
-              <Tag value="Neighborhood: Interstitial / Intracellular" />
-            </Tags>
-            <Children>
-              <Container id="VnSjMc-yF0-KqtiyJ6uzQw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="uVpNQJAUGEyTZHj73UQIMQ" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" dim="Velocity" quantityType="0" />
-                  <Parameter id="Qvf6v4Zq90SHL1OFEF4nZQ" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" dim="Velocity" quantityType="0" />
-                  <Parameter id="k2GVKEoapEGgzZ1ql3CQ_Q" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" dim="Flow (volume)" quantityType="0" />
-                  <Parameter id="wXoBO4jZeE6wpcaZm9FKfQ" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" dim="Flow (volume)" quantityType="0" />
-                  <Parameter id="qvNkOZuGXEieoNHRpoXzKw" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="GtuYYsFcUk-kzveq9zuitA" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="2JbEDsJ4EEif-nFRLzNzHA" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="BSLY0xuvIU-WqzgZd_WvpA" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" dim="Dimensionless" quantityType="0" />
-                </Children>
-              </Container>
-              <Parameter id="PLBdlO_psk-Fgo7qD2A_Iw" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_spl" dim="Surface" quantityType="0" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="wKwgOBHq4EqF4qk9FrHjKg" name="Spleen_pls_Spleen_bc" description="Neighborhood between Spleen/Plasma and Spleen/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="rc0YARtG-Eunbt8MATEJfw" secondNeighbor="kHaRuNvhZU2sFR-n9sC5oQ">
-            <Tags>
-              <Tag value="Spleen_pls_Spleen_bc" />
-              <Tag value="Neighborhood: Plasma / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="IUtbtQ1Ygki8QljC5JDN2g" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              <Parameter id="bNIexkeb5k6JTRw2GeuD2A" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" dim="Surface" quantityType="0" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="SCqXfGqFmECJbXV7YKry9A" name="Spleen_pls_Spleen_int" description="Neighborhood between Spleen/Plasma and Spleen/Interstitial" mode="Logical" containerType="Other" firstNeighbor="rc0YARtG-Eunbt8MATEJfw" secondNeighbor="wBcGoQrNPkmc-L9H-rAxeQ">
-            <Tags>
-              <Tag value="Spleen_pls_Spleen_int" />
-              <Tag value="Neighborhood: Plasma / Interstitial" />
-            </Tags>
-            <Children>
-              <Container id="pevEFLwJc0Cc3VCfYIDMCQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="TrajZOJQqE-BPGihPtu1Zw" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="Gi1fVCx54k2Gb8ylucXNng" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" formula="CKckyw2G8UayLIziC09gbQ" dim="Velocity" quantityType="0" />
-                </Children>
-              </Container>
-              <Parameter id="hGt3u5YgH0SEmK0kKCcU3A" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" dim="Surface" quantityType="0" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="peiwSkl1DUiOq1_SNGgn_A" name="Spleen_pls_PortalVein_pls" description="Neighborhood between Spleen/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="rc0YARtG-Eunbt8MATEJfw" secondNeighbor="w0IqwDHp6UGv317_8RFz7w">
-            <Tags>
-              <Tag value="Spleen_pls_PortalVein_pls" />
-              <Tag value="Neighborhood: Plasma / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="fvZTu_YlM0Ki3EppCtzYJg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="D0VMnETBwku5wd5iqU7oMg" name="Saliva_slv_Saliva_slv" description="Neighborhood between Saliva/SalivaGland and Saliva/Saliva" mode="Logical" containerType="Other" firstNeighbor="VIR7U2IoDUSBFGnqmfad_A" secondNeighbor="_6zflDoluUqVmHs9DMUJ3w">
-            <Tags>
-              <Tag value="Saliva_slv_Saliva_slv" />
-              <Tag value="Neighborhood: SalivaGland / Saliva" />
-            </Tags>
-            <Children>
-              <Container id="_gidsYW0NkCli2AITmDfPA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="jglOR6mgT0qo10iyc1rfPQ" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" formula="DistributionSaliva_PKSim.PARAM_K_cell_pls_slv" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="pnMpaWud4U6fGVfZVdRCWw" name="SalivaPlasmaRatio" description="Ratio of saliva vs. plasma concentrations" persistable="0" isFixedValue="0" formula="DistributionSaliva_PKSim.PARAM_SalivaPlasmaRatio" dim="Dimensionless" quantityType="0" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="T-NSWv7zQ0uEnPWbIi-Zpw" name="Duodenum_pls_Duodenum_int" description="Neighborhood between Small Intestine/Mucosa/Duodenum/Plasma and Small Intestine/Mucosa/Duodenum/Interstitial" mode="Logical" containerType="Other" firstNeighbor="Uw8BHY6NWESXphEVCwU2-Q" secondNeighbor="mQNOnFI5gkWapmSPOH2IGQ">
-            <Tags>
-              <Tag value="Duodenum_pls_Duodenum_int" />
-              <Tag value="Neighborhood: Plasma / Interstitial" />
-              <Tag value="Small intestine  neighborhood" />
-            </Tags>
-            <Children>
-              <Container id="PaGCBtPqu0248ScFERPJBQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="dYMBo-Qzo0a0KUgI_qYrNQ" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="7V2IPehr7Uq7CFn7jQ-xYQ" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" formula="fJEQdWnrakeWX9CodSh5DQ" dim="Velocity" quantityType="0" />
-                </Children>
-              </Container>
-              <Parameter id="DdkwfYfUmkukqsFrwFSirA" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" dim="Surface" quantityType="0" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="zhKGceNXIEqyWWmEGRRYHQ" name="Duodenum_pls_Duodenum_bc" description="Neighborhood between Small Intestine/Mucosa/Duodenum/Plasma and Small Intestine/Mucosa/Duodenum/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="Uw8BHY6NWESXphEVCwU2-Q" secondNeighbor="pkv5-3lim0ytLpaYYc02Bg">
-            <Tags>
-              <Tag value="Duodenum_pls_Duodenum_bc" />
-              <Tag value="Neighborhood: Plasma / BloodCells" />
-              <Tag value="Small intestine  neighborhood" />
-            </Tags>
-            <Children>
-              <Container id="QPOaAgHqR0224liQVHRGZw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              <Parameter id="6UTuz6Z1WUC9niD5fmdUwg" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" dim="Surface" quantityType="0" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="wyXCHtDzfEK-MItfbzBOkA" name="Duodenum_int_Duodenum_cell" description="Neighborhood between Small Intestine/Mucosa/Duodenum/Interstitial and Small Intestine/Mucosa/Duodenum/Intracellular" mode="Logical" containerType="Other" firstNeighbor="mQNOnFI5gkWapmSPOH2IGQ" secondNeighbor="Ky1ukmcECUWZ1yd2GXs5Yg">
-            <Tags>
-              <Tag value="Duodenum_int_Duodenum_cell" />
-              <Tag value="Neighborhood: Interstitial / Intracellular" />
-              <Tag value="Small intestine  neighborhood" />
-            </Tags>
-            <Children>
-              <Container id="Jb94OO-xWUmQov1hm3WOxw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="BF-DzikTaUGjC7Z9FKG5nw" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" dim="Velocity" quantityType="0" />
-                  <Parameter id="JrNHCxz82UGr9zk8phYgXg" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" dim="Flow (volume)" quantityType="0" />
-                  <Parameter id="gngxowrlBUOXnRC9VTb0IQ" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" dim="Flow (volume)" quantityType="0" />
-                  <Parameter id="K--JLWcvqU65AqlZB-676Q" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="5iARN5o_2U-RX2azOGHkvw" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="I8YiCnOHWkWD6gj2MWlEnw" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="Ez44czbyRU6p2q8tZAEwWw" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="43GKru7Qv0u2kDCAzaPXNQ" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" dim="Velocity" quantityType="0" />
-                </Children>
-              </Container>
-              <Parameter id="CGCaIY4LYEu431w5xd0D3w" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mucosa_duo" dim="Surface" quantityType="0" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="O-lzgz0N4U22X2cX4Uyqug" name="UpperJejunum_pls_UpperJejunum_bc" description="Neighborhood between Small Intestine/Mucosa/Upper Jejunum/Plasma and Small Intestine/Mucosa/Upper Jejunum/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="Y5LCVOCIvUeBojIUHl8qUg" secondNeighbor="WRMyELazgU6an4teJnpZQg">
-            <Tags>
-              <Tag value="UpperJejunum_pls_UpperJejunum_bc" />
-              <Tag value="Neighborhood: Plasma / BloodCells" />
-              <Tag value="Small intestine  neighborhood" />
-            </Tags>
-            <Children>
-              <Container id="Ptr6wTFZPU2zHMa4b4-kzg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              <Parameter id="_8kGg667QkS90CyftOpwqg" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" dim="Surface" quantityType="0" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="v3Wy_HcHXkG7GvVkDzUDUQ" name="UpperJejunum_int_UpperJejunum_cell" description="Neighborhood between Small Intestine/Mucosa/Upper Jejunum/Interstitial and Small Intestine/Mucosa/Upper Jejunum/Intracellular" mode="Logical" containerType="Other" firstNeighbor="ZTNzlNnynECErKkDEmJ9DA" secondNeighbor="hh0X-zoJO0ioIifqKclJWw">
-            <Tags>
-              <Tag value="UpperJejunum_int_UpperJejunum_cell" />
-              <Tag value="Neighborhood: Interstitial / Intracellular" />
-              <Tag value="Small intestine  neighborhood" />
-            </Tags>
-            <Children>
-              <Container id="QxZmKhP3JkeKq_WmshmxvA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="qRh35ArsyEOlDmofq8lBqA" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="WzWEvZvOEkWtGYl6q1EJJA" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="hYgtWCkXO0WNhEWqMnk8Mg" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" dim="Velocity" quantityType="0" />
-                  <Parameter id="91bfZYB600-oQou3UwUNVg" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" dim="Velocity" quantityType="0" />
-                  <Parameter id="BwamL3Gg2UahTzJ7hlfysg" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" dim="Flow (volume)" quantityType="0" />
-                  <Parameter id="l-Ia-YW-wkilGR2aL5BIgg" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" dim="Flow (volume)" quantityType="0" />
-                  <Parameter id="4-Hn4qp-D0ObJNSZC3pqfQ" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="YbFhQFXPYUKJZfTt_1U1ag" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" dim="Dimensionless" quantityType="0" />
-                </Children>
-              </Container>
-              <Parameter id="1jE1SELyTEmrIMdeT3RZnQ" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mucosa_uje" dim="Surface" quantityType="0" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="03yTVYxsB0S2lQci7yX6PA" name="UpperJejunum_pls_UpperJejunum_int" description="Neighborhood between Small Intestine/Mucosa/Upper Jejunum/Plasma and Small Intestine/Mucosa/Upper Jejunum/Interstitial" mode="Logical" containerType="Other" firstNeighbor="Y5LCVOCIvUeBojIUHl8qUg" secondNeighbor="ZTNzlNnynECErKkDEmJ9DA">
-            <Tags>
-              <Tag value="UpperJejunum_pls_UpperJejunum_int" />
-              <Tag value="Neighborhood: Plasma / Interstitial" />
-              <Tag value="Small intestine  neighborhood" />
-            </Tags>
-            <Children>
-              <Container id="6JfGNBsLwUOeVDzxEZ-WeA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="ZR1HXew8PkuxpiVPFccHUQ" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" formula="hlG3f04XYE-MrG8KIIT20Q" dim="Velocity" quantityType="0" />
-                  <Parameter id="xu2YPeFHbkiBS7tHKIg2PA" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" dim="Dimensionless" quantityType="0" />
-                </Children>
-              </Container>
-              <Parameter id="I1TGgxLLnEmEJQ8DYTcGtw" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" dim="Surface" quantityType="0" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="MgUU_IdEWUSf8p6EbiJzvg" name="LowerJejunum_pls_LowerJejunum_int" description="Neighborhood between Small Intestine/Mucosa/Lower Jejunum/Plasma and Small Intestine/Mucosa/Lower Jejunum/Interstitial" mode="Logical" containerType="Other" firstNeighbor="OSgBdGflYku_NnIddypazA" secondNeighbor="mFJVbWQiyEeTSVQGayMAUQ">
-            <Tags>
-              <Tag value="LowerJejunum_pls_LowerJejunum_int" />
-              <Tag value="Neighborhood: Plasma / Interstitial" />
-              <Tag value="Small intestine  neighborhood" />
-            </Tags>
-            <Children>
-              <Container id="w8p9-zhs7ke7iarWluHz_A" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="meF6UpImH0yIlzNuyJpdIQ" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" formula="rRySKmsqvU2Cl1tYLy5txA" dim="Velocity" quantityType="0" />
-                  <Parameter id="8mQbPXm3vUetHNbVWMaNog" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" dim="Dimensionless" quantityType="0" />
-                </Children>
-              </Container>
-              <Parameter id="IAbPlT4mzUyRSoVn1XnjHg" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" dim="Surface" quantityType="0" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="uLAWUcN_HEqYRozPTwZXYA" name="LowerJejunum_pls_LowerJejunum_bc" description="Neighborhood between Small Intestine/Mucosa/Lower Jejunum/Plasma and Small Intestine/Mucosa/Lower Jejunum/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="OSgBdGflYku_NnIddypazA" secondNeighbor="md8QdYDu-E2ZDBw6wj8WEg">
-            <Tags>
-              <Tag value="LowerJejunum_pls_LowerJejunum_bc" />
-              <Tag value="Neighborhood: Plasma / BloodCells" />
-              <Tag value="Small intestine  neighborhood" />
-            </Tags>
-            <Children>
-              <Container id="-Fx9f0Ath0aD3Ljs3Mp0Rg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              <Parameter id="7YAKmsluL0uo6HDlDPqX4Q" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" dim="Surface" quantityType="0" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="pNrcU5AZlUCiZeZT3sZSRA" name="LowerJejunum_int_LowerJejunum_cell" description="Neighborhood between Small Intestine/Mucosa/Lower Jejunum/Interstitial and Small Intestine/Mucosa/Lower Jejunum/Intracellular" mode="Logical" containerType="Other" firstNeighbor="mFJVbWQiyEeTSVQGayMAUQ" secondNeighbor="e7tmWdt_iUatH8wBlrecHA">
-            <Tags>
-              <Tag value="LowerJejunum_int_LowerJejunum_cell" />
-              <Tag value="Neighborhood: Interstitial / Intracellular" />
-              <Tag value="Small intestine  neighborhood" />
-            </Tags>
-            <Children>
-              <Container id="f04jLVRoF0a0O17NCqhqEA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="XEq40Fb3nEmja9hyT9wY1A" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" dim="Flow (volume)" quantityType="0" />
-                  <Parameter id="YFrzhyRH_k2xL-BfTh_j6A" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" dim="Flow (volume)" quantityType="0" />
-                  <Parameter id="dinw1ras7ky6giFdbJPN1w" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="XLtQJDyJFEua3uvSs4apxw" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="yHwA4eDEmEKSyoCpYRi2wg" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="HCVnW7F6eU-agGYBTXtb5Q" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="ZzOxhDYah0KMQVY_WWxtSg" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" dim="Velocity" quantityType="0" />
-                  <Parameter id="Zat_bEYlyEGz3h9Ey2RUZQ" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" dim="Velocity" quantityType="0" />
-                </Children>
-              </Container>
-              <Parameter id="vn354MxIMkiMUP7OU7JEew" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mucosa_lje" dim="Surface" quantityType="0" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="o9ZMkVqW90e_Uc9o1opTOA" name="UpperIleum_pls_UpperIleum_int" description="Neighborhood between Small Intestine/Mucosa/Upper Ileum/Plasma and Small Intestine/Mucosa/Upper Ileum/Interstitial" mode="Logical" containerType="Other" firstNeighbor="66G9xUKPyECPdQdGwnYfSw" secondNeighbor="Euo90j7RXEKG2jF2Qb1zJg">
-            <Tags>
-              <Tag value="UpperIleum_pls_UpperIleum_int" />
-              <Tag value="Neighborhood: Plasma / Interstitial" />
-              <Tag value="Small intestine  neighborhood" />
-            </Tags>
-            <Children>
-              <Container id="fbArLv_pdk-IaJDzn9jgfA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="valmLQlXDU-v6qkcMtSWFA" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="RlJgNU7e-kC4oN-QAl7owQ" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" formula="T4nzrgAtw0uAIH8vjdwCmw" dim="Velocity" quantityType="0" />
-                </Children>
-              </Container>
-              <Parameter id="7yoqDQ9YzECSBDgXl2A8zw" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" dim="Surface" quantityType="0" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="YH0lJazgA06-fS5xIrceww" name="UpperIleum_pls_UpperIleum_bc" description="Neighborhood between Small Intestine/Mucosa/Upper Ileum/Plasma and Small Intestine/Mucosa/Upper Ileum/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="66G9xUKPyECPdQdGwnYfSw" secondNeighbor="VDYdAer0LkaTdqAFYYkuhg">
-            <Tags>
-              <Tag value="UpperIleum_pls_UpperIleum_bc" />
-              <Tag value="Neighborhood: Plasma / BloodCells" />
-              <Tag value="Small intestine  neighborhood" />
-            </Tags>
-            <Children>
-              <Container id="oxU9RWYcT0mElA72AWuTZQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              <Parameter id="qgHhqLAi-0yGX9sIpL8cnw" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" dim="Surface" quantityType="0" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="RR5kFec4EE6LNT_kUyyYYg" name="UpperIleum_int_UpperIleum_cell" description="Neighborhood between Small Intestine/Mucosa/Upper Ileum/Interstitial and Small Intestine/Mucosa/Upper Ileum/Intracellular" mode="Logical" containerType="Other" firstNeighbor="Euo90j7RXEKG2jF2Qb1zJg" secondNeighbor="_XEu4SuUvUqKPjzK6x0c8w">
-            <Tags>
-              <Tag value="UpperIleum_int_UpperIleum_cell" />
-              <Tag value="Neighborhood: Interstitial / Intracellular" />
-              <Tag value="Small intestine  neighborhood" />
-            </Tags>
-            <Children>
-              <Container id="RRCBD7NNJ06y8yj0cLf5FA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="pk8XoSa_-EKGDuEF8fNg4A" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="eUhyRHKwD0GHDY0LGH1Vkw" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" dim="Velocity" quantityType="0" />
-                  <Parameter id="2xcHXz6MeE6pdzStbbKLvQ" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" dim="Velocity" quantityType="0" />
-                  <Parameter id="mpMFTnrMM06-LpKAyOP4Gw" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" dim="Flow (volume)" quantityType="0" />
-                  <Parameter id="v0CVLF4AhEiXI5f1x_DfYA" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" dim="Flow (volume)" quantityType="0" />
-                  <Parameter id="VHKKlLZbGEe6kkL5HrOcnQ" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="F8nC945VPkKBD7a9RTatPw" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="eFiAKjcr_EioA9zBH_0Esw" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" dim="Dimensionless" quantityType="0" />
-                </Children>
-              </Container>
-              <Parameter id="J2SnnnPeF0SCY5RWmFxdfQ" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mucosa_uil" dim="Surface" quantityType="0" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="3H83VZT1rkqcSDegXU289Q" name="LowerIleum_pls_LowerIleum_int" description="Neighborhood between Small Intestine/Mucosa/Lower Ileum/Plasma and Small Intestine/Mucosa/Lower Ileum/Interstitial" mode="Logical" containerType="Other" firstNeighbor="HOj-zR3PPUW6yX-B0rLz0g" secondNeighbor="J3IEuqYFyUSB5ap7fJ9EXQ">
-            <Tags>
-              <Tag value="LowerIleum_pls_LowerIleum_int" />
-              <Tag value="Neighborhood: Plasma / Interstitial" />
-              <Tag value="Small intestine  neighborhood" />
-            </Tags>
-            <Children>
-              <Container id="6bisWnB33Uyu0hqXBfdXmg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="eFF2t1utX0mU6IShHX5UqQ" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="MVvN0lY-ZEeu4Zo4B7DwIg" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" formula="xoD3ZoSqqkOlbNbl3MsH7g" dim="Velocity" quantityType="0" />
-                </Children>
-              </Container>
-              <Parameter id="rvK1DhSA8kKk9ocjh0vuBQ" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" dim="Surface" quantityType="0" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="C1YgfUkiKEunXCVQoZar8Q" name="LowerIleum_pls_LowerIleum_bc" description="Neighborhood between Small Intestine/Mucosa/Lower Ileum/Plasma and Small Intestine/Mucosa/Lower Ileum/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="HOj-zR3PPUW6yX-B0rLz0g" secondNeighbor="MFDAv_PfOkiQzDjjkslSHw">
-            <Tags>
-              <Tag value="LowerIleum_pls_LowerIleum_bc" />
-              <Tag value="Neighborhood: Plasma / BloodCells" />
-              <Tag value="Small intestine  neighborhood" />
-            </Tags>
-            <Children>
-              <Container id="UQWCesk8zkiav42GGUcdZw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              <Parameter id="aI63wHdsPE2D7Y6_v_CNuA" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" dim="Surface" quantityType="0" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="acqR9HXxW0udLxB0M47sEg" name="LowerIleum_int_LowerIleum_cell" description="Neighborhood between Small Intestine/Mucosa/Lower Ileum/Interstitial and Small Intestine/Mucosa/Lower Ileum/Intracellular" mode="Logical" containerType="Other" firstNeighbor="J3IEuqYFyUSB5ap7fJ9EXQ" secondNeighbor="O2GTTPwRekuvYZ3QMo8Raw">
-            <Tags>
-              <Tag value="LowerIleum_int_LowerIleum_cell" />
-              <Tag value="Neighborhood: Interstitial / Intracellular" />
-              <Tag value="Small intestine  neighborhood" />
-            </Tags>
-            <Children>
-              <Container id="4H_VK_xVMkOqz6snJ-Nzbw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="Rz-cEGSKZEuPalS3zx-scQ" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="o0lZjxCXqkaQVX-6aHTwww" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" dim="Velocity" quantityType="0" />
-                  <Parameter id="0wrJCkRTkk6HW8c-Nk-mpg" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" dim="Velocity" quantityType="0" />
-                  <Parameter id="Bjp_azMz_ke-V9zGoFxOMw" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" dim="Flow (volume)" quantityType="0" />
-                  <Parameter id="FMYJPUjfv02vL7Hzj98nqQ" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="EyLKCUEKwUuKEBMVOy_-rg" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="TyTA3dpmWkualTnFprGdeA" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="ABjJQgFs-ESVcrlJrQKifg" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" dim="Flow (volume)" quantityType="0" />
-                </Children>
-              </Container>
-              <Parameter id="ALpxyj3eKUa28i9CxKiptQ" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mucosa_lil" dim="Surface" quantityType="0" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="BVQV3ANkV0yiY_Yb5RDoNQ" name="Caecum_pls_Caecum_int" description="Neighborhood between Large Intestine/Mucosa/Cecum/Plasma and Large Intestine/Mucosa/Cecum/Interstitial" mode="Logical" containerType="Other" firstNeighbor="CKUV4Ze6d0eoYQnRGiicug" secondNeighbor="DO-uiyvH6kydG7Dl1iSS2Q">
-            <Tags>
-              <Tag value="Caecum_pls_Caecum_int" />
-              <Tag value="Large intestine  neighborhood" />
-              <Tag value="Neighborhood: Plasma / Interstitial" />
-            </Tags>
-            <Children>
-              <Container id="QbIX2fQYy02PSt1BxO-GLw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="KyqgkI1uSU65Aze5PDFzTg" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="zM_DzIE4pkKnrxYBbOC02Q" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" formula="OL0sw7Ll7UyJnu2bLoobjA" dim="Velocity" quantityType="0" />
-                </Children>
-              </Container>
-              <Parameter id="h9dESafJqECmIYxJNWo8Jg" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" dim="Surface" quantityType="0" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="CadqeWSuEE-8J-7Ov_FliA" name="Caecum_pls_Caecum_bc" description="Neighborhood between Large Intestine/Mucosa/Cecum/Plasma and Large Intestine/Mucosa/Cecum/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="CKUV4Ze6d0eoYQnRGiicug" secondNeighbor="b6vJ67uVlUGBdmnT37TEDw">
-            <Tags>
-              <Tag value="Caecum_pls_Caecum_bc" />
-              <Tag value="Large intestine  neighborhood" />
-              <Tag value="Neighborhood: Plasma / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="lP11EgNGaEKUFT2UzHFYNQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              <Parameter id="kgJi6mOJokmmSCpJ3DThNA" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" dim="Surface" quantityType="0" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="gVSBgLQ9LEqF8kp91HIn3A" name="Caecum_int_Caecum_cell" description="Neighborhood between Large Intestine/Mucosa/Cecum/Interstitial and Large Intestine/Mucosa/Cecum/Intracellular" mode="Logical" containerType="Other" firstNeighbor="DO-uiyvH6kydG7Dl1iSS2Q" secondNeighbor="H5cljX5ikE-xPBwWkmCcVw">
-            <Tags>
-              <Tag value="Caecum_int_Caecum_cell" />
-              <Tag value="Large intestine  neighborhood" />
-              <Tag value="Neighborhood: Interstitial / Intracellular" />
-            </Tags>
-            <Children>
-              <Container id="M-9-OAg_aUi1p2FuS-51Bg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="76FTwDq3UE2inFZGzKHm3w" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="SpDNbLfiH0q7ZZPnrfIdVg" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" dim="Velocity" quantityType="0" />
-                  <Parameter id="7451jwFsFkOvBHBL3qkvaQ" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" dim="Velocity" quantityType="0" />
-                  <Parameter id="JFGWs2ELV0OCmf8tVAsdiA" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" dim="Flow (volume)" quantityType="0" />
-                  <Parameter id="36QfrVG8qEuW78xo05OxTQ" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="oKq-PHIlRE6BcgefgdfErA" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="KrH0qR2WfU2t0sfDa4pW3A" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="Qa2BenhngEuyXiPXcowLZA" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" dim="Flow (volume)" quantityType="0" />
-                </Children>
-              </Container>
-              <Parameter id="EKG_nXOsp0eYoxhGUVL1-w" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mucosa_cae" dim="Surface" quantityType="0" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="ymuN_i6GBUWZlAFGiSVCAA" name="ColonAscendens_pls_ColonAscendens_int" description="Neighborhood between Large Intestine/Mucosa/Colon Ascendens/Plasma and Large Intestine/Mucosa/Colon Ascendens/Interstitial" mode="Logical" containerType="Other" firstNeighbor="lD1ALP8VY0eUEmlEri8jWA" secondNeighbor="WxXF7NOOo0S5mxz-XY-A6g">
-            <Tags>
-              <Tag value="ColonAscendens_pls_ColonAscendens_int" />
-              <Tag value="Large intestine  neighborhood" />
-              <Tag value="Neighborhood: Plasma / Interstitial" />
-            </Tags>
-            <Children>
-              <Container id="Lih-qeLnPky14i_jN2s8QQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="2DfZL_HD0EKsPL0sJL6N7Q" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" formula="Pau2AQsMdU2F4TZ0Wz550A" dim="Velocity" quantityType="0" />
-                  <Parameter id="Yr9VdaF45E2GkvGB8WZuNw" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" dim="Dimensionless" quantityType="0" />
-                </Children>
-              </Container>
-              <Parameter id="SA2lPtjJs0e10bdUyg2IqA" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" dim="Surface" quantityType="0" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="xU7HMixKOEqX3qLCtkElSg" name="ColonAscendens_int_ColonAscendens_cell" description="Neighborhood between Large Intestine/Mucosa/Colon Ascendens/Interstitial and Large Intestine/Mucosa/Colon Ascendens/Intracellular" mode="Logical" containerType="Other" firstNeighbor="WxXF7NOOo0S5mxz-XY-A6g" secondNeighbor="hvfn0Cc3kU2or6mhw1stFA">
-            <Tags>
-              <Tag value="ColonAscendens_int_ColonAscendens_cell" />
-              <Tag value="Large intestine  neighborhood" />
-              <Tag value="Neighborhood: Interstitial / Intracellular" />
-            </Tags>
-            <Children>
-              <Container id="LuMhqrieJEajak7KWM7Qbg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="vzL7U7-ZMUqz673it8kXXw" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" dim="Flow (volume)" quantityType="0" />
-                  <Parameter id="NSwfh-5n9kKAnU8mJtRr_w" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" dim="Velocity" quantityType="0" />
-                  <Parameter id="D2FT6L7AiU2miDxLKYGRXQ" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" dim="Flow (volume)" quantityType="0" />
-                  <Parameter id="gd0O3MMnD0SEXnLfWKrfzA" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="vz0N7EQGh0y-QtN44kPjoA" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="LFDXziIMzUKTQdshf9QsTQ" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="AuUYhgNu4EOrMJHdLkjhlQ" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="XARTWrFw2kupZ6wOGvdQEQ" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" dim="Velocity" quantityType="0" />
-                </Children>
-              </Container>
-              <Parameter id="4FruhteGIUarfUR0j74OTw" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mucosa_colasc" dim="Surface" quantityType="0" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="7sCCoKSjNkWAZ39-OxyCjQ" name="ColonAscendens_pls_ColonAscendens_bc" description="Neighborhood between Large Intestine/Mucosa/Colon Ascendens/Plasma and Large Intestine/Mucosa/Colon Ascendens/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="lD1ALP8VY0eUEmlEri8jWA" secondNeighbor="61Zi-_Bk6k2KAceYwRaXCw">
-            <Tags>
-              <Tag value="ColonAscendens_pls_ColonAscendens_bc" />
-              <Tag value="Large intestine  neighborhood" />
-              <Tag value="Neighborhood: Plasma / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="ZCUOYIK3WEWHhR84eE5dDQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              <Parameter id="_-8lxBVPi0OYVUCMfiC5KQ" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" dim="Surface" quantityType="0" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="wXSXQSXLwU2E02f-XSMqmg" name="ColonTransversum_pls_ColonTransversum_bc" description="Neighborhood between Large Intestine/Mucosa/Colon Transversum/Plasma and Large Intestine/Mucosa/Colon Transversum/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="iPvRkWZ76UCcWPzFPJlJxQ" secondNeighbor="k3eDZxhGcUSx99US8MzGjg">
-            <Tags>
-              <Tag value="ColonTransversum_pls_ColonTransversum_bc" />
-              <Tag value="Large intestine  neighborhood" />
-              <Tag value="Neighborhood: Plasma / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="yDv1C3Wr20C5j1bouwdDVQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              <Parameter id="EmNXzrUW_kuCz86lVieEyA" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" dim="Surface" quantityType="0" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="vbH8tqMz_0q8isVKx5wMOw" name="ColonTransversum_pls_ColonTransversum_int" description="Neighborhood between Large Intestine/Mucosa/Colon Transversum/Plasma and Large Intestine/Mucosa/Colon Transversum/Interstitial" mode="Logical" containerType="Other" firstNeighbor="iPvRkWZ76UCcWPzFPJlJxQ" secondNeighbor="wRo9qjn_cEa29Q-7tBy4zw">
-            <Tags>
-              <Tag value="ColonTransversum_pls_ColonTransversum_int" />
-              <Tag value="Large intestine  neighborhood" />
-              <Tag value="Neighborhood: Plasma / Interstitial" />
-            </Tags>
-            <Children>
-              <Container id="QggPBM-YdECE4l2Rh-ANUw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="VcRAJc5hC0y_B-asdN6ZXA" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="3N9yMbQzI0yKTla6nokpIQ" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" formula="jxV9dNPQvk6BZ0obwTaTdw" dim="Velocity" quantityType="0" />
-                </Children>
-              </Container>
-              <Parameter id="tfh6RdFh9EuF7XAlQ4eObg" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" dim="Surface" quantityType="0" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="bH-bSAxOrkGZ0MdCZ1T63w" name="ColonTransversum_int_ColonTransversum_cell" description="Neighborhood between Large Intestine/Mucosa/Colon Transversum/Interstitial and Large Intestine/Mucosa/Colon Transversum/Intracellular" mode="Logical" containerType="Other" firstNeighbor="wRo9qjn_cEa29Q-7tBy4zw" secondNeighbor="x1kSFFO9_kq-91UQyO7UCw">
-            <Tags>
-              <Tag value="ColonTransversum_int_ColonTransversum_cell" />
-              <Tag value="Large intestine  neighborhood" />
-              <Tag value="Neighborhood: Interstitial / Intracellular" />
-            </Tags>
-            <Children>
-              <Container id="9n2oAN83I0O1Yd_Yk8jZQQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="Jn-bSVAlRE-CUY0esQ3HHw" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" dim="Velocity" quantityType="0" />
-                  <Parameter id="HESQYveSCk--ygTQD5Ntbg" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" dim="Velocity" quantityType="0" />
-                  <Parameter id="kAwoJlDRa0GNjpVb_AlDbg" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" dim="Flow (volume)" quantityType="0" />
-                  <Parameter id="rXy7ND-nR0eyRFPXbxNMcg" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" dim="Flow (volume)" quantityType="0" />
-                  <Parameter id="wPB7GmBHvUyNB8ld7jxhBA" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="jYUDy81pwEWUst7W01oyQA" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="O2Kz2AjQg02unZFHbSK5IA" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="72kZ1eCmy0e9K2wfmXYqiA" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" dim="Dimensionless" quantityType="0" />
-                </Children>
-              </Container>
-              <Parameter id="Uf0vlViIEkyO-lgnjXwnGg" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mucosa_coltrans" dim="Surface" quantityType="0" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="jqXsJbtabEe4YZjKeKlJTg" name="ColonDescendens_pls_ColonDescendens_int" description="Neighborhood between Large Intestine/Mucosa/Colon Descendens/Plasma and Large Intestine/Mucosa/Colon Descendens/Interstitial" mode="Logical" containerType="Other" firstNeighbor="z4zcH_HhW0yr4B9Cwg_sfw" secondNeighbor="_DlcNLs4P0-oyPZTTygREA">
-            <Tags>
-              <Tag value="ColonDescendens_pls_ColonDescendens_int" />
-              <Tag value="Large intestine  neighborhood" />
-              <Tag value="Neighborhood: Plasma / Interstitial" />
-            </Tags>
-            <Children>
-              <Container id="n6d9X1jqFkOhqSzbfEji9g" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="4JfMczooNUCuL20wqgZRqw" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" formula="sJ37omMJfkOSU3ughWpdqg" dim="Velocity" quantityType="0" />
-                  <Parameter id="_FfH3xlvvEumZ0V-sauHxQ" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" dim="Dimensionless" quantityType="0" />
-                </Children>
-              </Container>
-              <Parameter id="VPWkCHWLE0-kC4SHr641GA" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" dim="Surface" quantityType="0" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="4eEAlL2IHE2_S6O3FIQ2ng" name="ColonDescendens_pls_ColonDescendens_bc" description="Neighborhood between Large Intestine/Mucosa/Colon Descendens/Plasma and Large Intestine/Mucosa/Colon Descendens/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="z4zcH_HhW0yr4B9Cwg_sfw" secondNeighbor="XK3vUE0RlU2Uq4VMEUyDFQ">
-            <Tags>
-              <Tag value="ColonDescendens_pls_ColonDescendens_bc" />
-              <Tag value="Large intestine  neighborhood" />
-              <Tag value="Neighborhood: Plasma / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="MbSsxYod6kKfb1Ov6SR5nA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              <Parameter id="j9ximsR1A0SG9kJrYPnuzA" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" dim="Surface" quantityType="0" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="Jr0N8lyiQkaS3D9JRD9YCw" name="ColonDescendens_int_ColonDescendens_cell" description="Neighborhood between Large Intestine/Mucosa/Colon Descendens/Interstitial and Large Intestine/Mucosa/Colon Descendens/Intracellular" mode="Logical" containerType="Other" firstNeighbor="_DlcNLs4P0-oyPZTTygREA" secondNeighbor="vZZk3ffGfEecawifpPNcpA">
-            <Tags>
-              <Tag value="ColonDescendens_int_ColonDescendens_cell" />
-              <Tag value="Large intestine  neighborhood" />
-              <Tag value="Neighborhood: Interstitial / Intracellular" />
-            </Tags>
-            <Children>
-              <Container id="cqxqzOjgJkWssWPDZQ0rjQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="yXK5q7IQdkqSkVDxqCDQkQ" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="5pGFGRpbgESKdnM47vMmSQ" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="-VQekKTWEkS8-f-GZS0g3Q" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="wLKxOrMFx02Q6XlWlosZrg" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="gF8YEUn3rES7wMyWYqCFbQ" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" dim="Flow (volume)" quantityType="0" />
-                  <Parameter id="25p4fOOxz0-iZZwEde-8zQ" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" dim="Velocity" quantityType="0" />
-                  <Parameter id="OT7wj4jAhU-Q8dHjeJyN6A" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" dim="Velocity" quantityType="0" />
-                  <Parameter id="hj4msKp9TU6JYttyG5DtYA" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" dim="Flow (volume)" quantityType="0" />
-                </Children>
-              </Container>
-              <Parameter id="HVmvpyFE70CfgWcyWO7EmQ" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mucosa_coldesc" dim="Surface" quantityType="0" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="bHS9wW33G0K2fAumiY4_XQ" name="ColonSigmoid_pls_ColonSigmoid_int" description="Neighborhood between Large Intestine/Mucosa/Colon Sigmoid/Plasma and Large Intestine/Mucosa/Colon Sigmoid/Interstitial" mode="Logical" containerType="Other" firstNeighbor="FyoEzv-8O0WMSz47wtJ9gg" secondNeighbor="0V3VgRSNWEK4JG3IV72CEw">
-            <Tags>
-              <Tag value="ColonSigmoid_pls_ColonSigmoid_int" />
-              <Tag value="Large intestine  neighborhood" />
-              <Tag value="Neighborhood: Plasma / Interstitial" />
-            </Tags>
-            <Children>
-              <Container id="8GASIzTaU06NBXHUiOI4cA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="y_6fzZTbw0O_HfWznlKk7w" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" formula="ENhNxqvYmUaPtSj95TblEg" dim="Velocity" quantityType="0" />
-                  <Parameter id="RgnrJQwcJEWe5m6RBewTPA" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" dim="Dimensionless" quantityType="0" />
-                </Children>
-              </Container>
-              <Parameter id="I5wMvAL5JES4r0WpsOXgDw" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" dim="Surface" quantityType="0" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="mQy8Ei1Kg0KcLkkigIEt2Q" name="ColonSigmoid_pls_ColonSigmoid_bc" description="Neighborhood between Large Intestine/Mucosa/Colon Sigmoid/Plasma and Large Intestine/Mucosa/Colon Sigmoid/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="FyoEzv-8O0WMSz47wtJ9gg" secondNeighbor="Yo5tHCCFQUekhjV8Ghb7RQ">
-            <Tags>
-              <Tag value="ColonSigmoid_pls_ColonSigmoid_bc" />
-              <Tag value="Large intestine  neighborhood" />
-              <Tag value="Neighborhood: Plasma / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="66jTv0VIS0iF7kwDtaMnag" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              <Parameter id="_2c97Y8ZV0OvHv-RnYWcQQ" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" dim="Surface" quantityType="0" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="imgshGOZiEeg4sJYC3ePmQ" name="ColonSigmoid_int_ColonSigmoid_cell" description="Neighborhood between Large Intestine/Mucosa/Colon Sigmoid/Interstitial and Large Intestine/Mucosa/Colon Sigmoid/Intracellular" mode="Logical" containerType="Other" firstNeighbor="0V3VgRSNWEK4JG3IV72CEw" secondNeighbor="7Y9A4sqt2Eig287pq_CdWg">
-            <Tags>
-              <Tag value="ColonSigmoid_int_ColonSigmoid_cell" />
-              <Tag value="Large intestine  neighborhood" />
-              <Tag value="Neighborhood: Interstitial / Intracellular" />
-            </Tags>
-            <Children>
-              <Container id="BTy3jUd_90uk--tYTFcOnQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="epOegrI150WHt5UKY4zBfQ" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" dim="Flow (volume)" quantityType="0" />
-                  <Parameter id="U0p3HVqg8EukENdyZrVAYA" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" dim="Flow (volume)" quantityType="0" />
-                  <Parameter id="rIj45Z5rlUW5AOCYC7c5Pw" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="f4yPmH2CF02EsXYzNvTP5w" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="jOfb_7Ihr0SHZlnfSZSmSg" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="VaM_ROYpYE6C0HU6YdtZJQ" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="o5jXPbmN1EaEAZ6NwLfaHw" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" dim="Velocity" quantityType="0" />
-                  <Parameter id="1oma1sfpFkS2zn25xMuqjw" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" dim="Velocity" quantityType="0" />
-                </Children>
-              </Container>
-              <Parameter id="eX1TUpnCtEeJ6WoSHcH9sw" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mucosa_colsigm" dim="Surface" quantityType="0" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="g46jdnE1TEGPE4iyQkru2Q" name="Rectum_int_Rectum_cell" description="Neighborhood between Large Intestine/Mucosa/Rectum/Interstitial and Large Intestine/Mucosa/Rectum/Intracellular" mode="Logical" containerType="Other" firstNeighbor="kneyb0hNCECbiWiCu5EmKA" secondNeighbor="QsQ9xRaAm0yGNxNTxJ3PuA">
-            <Tags>
-              <Tag value="Rectum_int_Rectum_cell" />
-              <Tag value="Large intestine  neighborhood" />
-              <Tag value="Neighborhood: Interstitial / Intracellular" />
-            </Tags>
-            <Children>
-              <Container id="xSIPhixaO0KoOCzK9Q7eWQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="oeeGkUiyekC5mf5tfujeow" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="stEyLHnllkW6DxUnVX0E3g" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_P_int_cell" dim="Velocity" quantityType="0" />
-                  <Parameter id="5jT_-Gc_7kCJK6wTQ2WPOw" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_P_cell_int" dim="Velocity" quantityType="0" />
-                  <Parameter id="jLJ62C1P-UeHOs_Z-Hxuig" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_PA_int_cell" dim="Flow (volume)" quantityType="0" />
-                  <Parameter id="z88r4gQXEUuZ5fDZRtex9g" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.CELLULAR PERMEABILITY FACTOR RATE" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="eUcbRGbR-US6QZEkzQL9LQ" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.PARTITION COEFFICIENT FORMULA" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="jWZpyPqFR0mP1vQs5VfT5A" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_wat_cell" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="AyTAucDFt0qkos9YcdEzrw" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="DiffusionCommon_PKSim.PARAM_PA_cell_int" dim="Flow (volume)" quantityType="0" />
-                </Children>
-              </Container>
-              <Parameter id="as7kaStX8E2BKpTXmQM7Qw" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" formula="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mucosa_rect" dim="Surface" quantityType="0" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="XwEMtGg-_0aC_79mYHDCyg" name="Rectum_pls_Rectum_bc" description="Neighborhood between Large Intestine/Mucosa/Rectum/Plasma and Large Intestine/Mucosa/Rectum/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="eJzNOCYba06diGWhCWqi1Q" secondNeighbor="udxtFKMRFUe0Mj2-C-W3hg">
-            <Tags>
-              <Tag value="Rectum_pls_Rectum_bc" />
-              <Tag value="Large intestine  neighborhood" />
-              <Tag value="Neighborhood: Plasma / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="jxNHtsEaSUOw4-ZHwMpZTQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-              <Parameter id="Q5UBFdorwkarTn2eBCC83A" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" formula="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" dim="Surface" quantityType="0" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="PP5qCKtkBk2S5eNJ7gh00Q" name="Rectum_pls_Rectum_int" description="Neighborhood between Large Intestine/Mucosa/Rectum/Plasma and Large Intestine/Mucosa/Rectum/Interstitial" mode="Logical" containerType="Other" firstNeighbor="eJzNOCYba06diGWhCWqi1Q" secondNeighbor="kneyb0hNCECbiWiCu5EmKA">
-            <Tags>
-              <Tag value="Rectum_pls_Rectum_int" />
-              <Tag value="Large intestine  neighborhood" />
-              <Tag value="Neighborhood: Plasma / Interstitial" />
-            </Tags>
-            <Children>
-              <Container id="2UBFlriLpE6IzjTz2-I1eA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="qvMbepyJpU64OIY1jcYGZQ" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" formula="u6miwZmfY0mg0xkEWlSlXg" dim="Velocity" quantityType="0" />
-                  <Parameter id="XZpONZra-UiWggfqSKiWBQ" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" formula="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" dim="Dimensionless" quantityType="0" />
-                </Children>
-              </Container>
-              <Parameter id="RAT5tRxV2UmMT_V7oYrSzA" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" formula="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" dim="Surface" quantityType="0" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="t39GVve-j0elvlmgajYihg" name="ColonTransversum_pls_PortalVein_pls" description="Neighborhood between Colon Transversum/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="iPvRkWZ76UCcWPzFPJlJxQ" secondNeighbor="w0IqwDHp6UGv317_8RFz7w">
-            <Tags>
-              <Tag value="ColonTransversum_pls_PortalVein_pls" />
-              <Tag value="Neighborhood: Plasma / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="iGQFufak4EWEDXx5JlDE4w" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="1v2gHP-wYkqM394pMi8ivQ" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" persistable="0" isFixedValue="0" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPvePlasma" dim="Rate" quantityType="0" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="dBIAtckhnkeoBMSohPZd1w" name="Lumen_colsigm_ColonSigmoid_cell" description="Neighborhood between Lumen/Colon Sigmoid and Mucosa/Colon Sigmoid/Intracellular" mode="Logical" containerType="Other" firstNeighbor="Bi4ZMIHKqEWJTZaSDxNssw" secondNeighbor="7Y9A4sqt2Eig287pq_CdWg">
-            <Tags>
-              <Tag value="Lumen_colsigm_ColonSigmoid_cell" />
-              <Tag value="Neighborhood: ColonSigmoid / Intracellular" />
-            </Tags>
-            <Children>
-              <Container id="jIE7zrzUskmhMzgCsi0gww" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="HUJxXDFE4UK-5ojvPP_IKQ" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F3" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="VY7XqwaB6kOC4SgWyLWa0Q" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F2" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="i_mYLgpjn0qKCWNNYg-4Jg" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F1" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="1EadDO8pT06dHXv1-M0ROw" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_ColonSigmoid" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="_LhZI0t0u0-LbFP2VURf8Q" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_K_cell_pls_ColonSigmoid" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="d45xsptR1UmACSbAgcJtuw" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_lum_cell_factor" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="5gkIMblk1ky8Ukvymr28YQ" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_cell_lum_factor" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="l-9Lu7z0qkaJEzfYbFoMAA" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_DrugAbsorption_trans" dim="Rate" quantityType="0" />
-                  <Parameter id="_Hf_TJjhSEixaNkYp_6qgA" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K2" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="jPj0D5X-rEit5gQT7_CMqg" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K3" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="opGh_0I1FkKjsqmpzyEtGw" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K6" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="lSVEalgEJ06n0qpUr73UnA" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K1" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="lIzBh1-tcUGcdVAuqjsBPA" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K7" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="J5gw0EwYwEKVR_b8fxutcQ" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K5" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="9xgFmJblmkODnGhEs0r8Rg" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K4" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="_fzsTC7Y90u29-m1S9eX4w" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K3" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="261S_prgL0SFYWJd7MmbhA" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K2" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="hU4gJ52dX06wegMWRqPrBQ" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K1" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="CZvjtLQWI0SzcqWuWbyO3g" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F3" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="y-LZFTqujE2xMC4SyhWFZA" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F2" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="dbTbtdjkbkC0z8yp2GEgZA" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F1" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="iKytwxmLB0KZpoLkqOJC-Q" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K8" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="6C2ScOtWME6gVlGBZj4qpA" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K7" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="tOFYCJ0pYEGicx33SeR-DQ" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K6" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="98lSd1llA0OpHiET7PaRXg" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K5" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="fgkzTJKHI0OmVfjnGWdo4w" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K4" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="tgQcRcbbiE2xQAZ4KmxkNQ" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K8" dim="Dimensionless" quantityType="0" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="H6-xHehcQEGl3Ke-7Bc8Gw" name="Caecum_bc_PortalVein_bc" description="Neighborhood between Cecum/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="b6vJ67uVlUGBdmnT37TEDw" secondNeighbor="f1NQXRLB-0m-az7rPFpZXw">
-            <Tags>
-              <Tag value="Caecum_bc_PortalVein_bc" />
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="VaZLMzfEPkW60yrDydt_jg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="UB_5-Iv3D0OOwkyNFsZLXA" name="Mass transfer rate (mucosa to portal vein blood cells)" description="Mass transfer rate (mucosa to portal vein blood cells)" persistable="0" isFixedValue="0" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPveBloodCells" dim="Rate" quantityType="0" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="9_gZIrrRP0C2BH7c17T9Zw" name="Lumen_colasc_ColonAscendens_pls" description="Neighborhood between Lumen/Colon Ascendens and Mucosa/Colon Ascendens/Plasma" mode="Logical" containerType="Other" firstNeighbor="px9VS6HKjEufLOLkVEmyiQ" secondNeighbor="lD1ALP8VY0eUEmlEri8jWA">
-            <Tags>
-              <Tag value="Lumen_colasc_ColonAscendens_pls" />
-              <Tag value="Neighborhood: ColonAscendens / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="NNu-1Iwsp0mNML04HEzMoQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="zNLX84tj2k-p9G65n5a6WQ" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_DrugAbsorption_para" dim="Rate" quantityType="0" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="3JoOsKBzi06WHAqoHyQ-JQ" name="Lumen_colasc_ColonAscendens_cell" description="Neighborhood between Lumen/Colon Ascendens and Mucosa/Colon Ascendens/Intracellular" mode="Logical" containerType="Other" firstNeighbor="px9VS6HKjEufLOLkVEmyiQ" secondNeighbor="hvfn0Cc3kU2or6mhw1stFA">
-            <Tags>
-              <Tag value="Lumen_colasc_ColonAscendens_cell" />
-              <Tag value="Neighborhood: ColonAscendens / Intracellular" />
-            </Tags>
-            <Children>
-              <Container id="AZFvaPZY-EaW4sQYRLTzpg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="vATXLI3Duk2kOPSAmjRlNw" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K6" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="g2mmOF7SF0ysnBFJJEv3Dw" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K8" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="h9WaZRHOMkCtmMXfyJGLcQ" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K7" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="Lcb9ABlKKE-KAMco5DeMag" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K6" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="STrN8dYFS0iGHgFq_OFpNg" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K5" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="9InFNsYMJkeAP_SxBbICqA" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K4" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="WPi9NFFE-kqfBE3V9KG2Xg" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K3" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="nUC_qX7poUK9mkQWvo-z5g" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K2" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="QO91Df8Hc02gR6P6LocBjA" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K1" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="p1c10DZTEk258EQyAMpJJQ" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F3" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="2ygOyyW_yEmE03c64DRECg" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F2" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="fVdf8zcnZ0mg1codg604Lw" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F1" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="8vHaSCZrJ0ut7p1krHiTIw" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K7" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="79wGfYLBjEay9Qnh4YHSXA" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K5" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="kUjJSPTRZUysUl40syujyQ" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K4" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="6eKO2HaQqk2PkIcWMoTPHw" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K3" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="YTdKIhbef0ymR_8wGReiIg" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K2" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="oRUJs46CsU65cVZDqToiRg" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K1" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="c1_wWVMClUqywwKSLFZN0A" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F3" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="2V5Gu3TjY0yAIGkt4Dp4lw" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F2" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="JjC2-glRm0KzYkhB60wpQA" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F1" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="aOe8nCvgFEesDnIgpAClaQ" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_ColonAscendens" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="dbWIxuaG-kKAFDPMNYfrcg" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_K_cell_pls_ColonAscendens" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="y7QpeZw4Z0mCKGOuhfKwYQ" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_lum_cell_factor" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="5foVLlN69kSYLNdhzWGj0Q" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_cell_lum_factor" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="VxiWDdm-NESX3PvbXxkrnQ" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_DrugAbsorption_trans" dim="Rate" quantityType="0" />
-                  <Parameter id="NrWjez7rN0S-p7YPMOGdAQ" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K8" dim="Dimensionless" quantityType="0" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="6pANBd9gm02Fw9JJ2Hqg_w" name="ColonAscendens_pls_PortalVein_pls" description="Neighborhood between Colon Ascendens/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="lD1ALP8VY0eUEmlEri8jWA" secondNeighbor="w0IqwDHp6UGv317_8RFz7w">
-            <Tags>
-              <Tag value="ColonAscendens_pls_PortalVein_pls" />
-              <Tag value="Neighborhood: Plasma / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="ccDjsXm34UypYbJrtHjA2Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="MtUuEPmBmE6_jyhgDl-aiw" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" persistable="0" isFixedValue="0" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPvePlasma" dim="Rate" quantityType="0" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="JWKm3_HzaEWpoRPMzjF3MA" name="ColonAscendens_bc_PortalVein_bc" description="Neighborhood between Colon Ascendens/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="61Zi-_Bk6k2KAceYwRaXCw" secondNeighbor="f1NQXRLB-0m-az7rPFpZXw">
-            <Tags>
-              <Tag value="ColonAscendens_bc_PortalVein_bc" />
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="WX6ynWAc40aI0bqrq0-qsQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="E4FOhskKoUu_2eeUY8ygQQ" name="Mass transfer rate (mucosa to portal vein blood cells)" description="Mass transfer rate (mucosa to portal vein blood cells)" persistable="0" isFixedValue="0" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPveBloodCells" dim="Rate" quantityType="0" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="B7WuLrz3A0OrSC-2ffmm5Q" name="Lumen_cae_Caecum_cell" description="Neighborhood between Lumen/Cecum and Mucosa/Cecum/Intracellular" mode="Logical" containerType="Other" firstNeighbor="Tb_XB9kBdEijMjvfTLCFmg" secondNeighbor="H5cljX5ikE-xPBwWkmCcVw">
-            <Tags>
-              <Tag value="Lumen_cae_Caecum_cell" />
-              <Tag value="Neighborhood: Caecum / Intracellular" />
-            </Tags>
-            <Children>
-              <Container id="pp6NUwBNbEWrUI6YV3lyMA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="ozy4cunev0CohYb6c3Y0RA" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_Caecum" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="QiA8jadpJUiR1x85KqPEvQ" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_DrugAbsorption_trans" dim="Rate" quantityType="0" />
-                  <Parameter id="oV5g74qdeECHinJw9sQ4KQ" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_cell_lum_factor" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="9wj2wMFLCk-EiQoi3S2MfA" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_lum_cell_factor" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="nHlf-UR9qkeGZmn9ynaVmg" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_K_cell_pls_Caecum" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="n5veHAqDlUmr8anPrONBqQ" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F1" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="XqPSBPuEiUWIRWemejD-lQ" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K1" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="vn8xiCUGrUuqREsX9IPvLA" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K8" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="tI1joQY4fUKy9Dp2HoTY5w" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K7" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="9Fg5_crXfk6ZVociTIm7Zw" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K6" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="CUXRuSf4-0WWCkpbqukdSQ" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K5" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="hMw-BnyEd0y2c3AyITuKSg" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K4" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="lTany6EaMUS5d4Nk0iKfFw" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K2" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="v447vkMBcUCYJZpkU0tASQ" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F3" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="mjMM0HrGeEmB7O4-pt5fkw" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F2" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="YYfjyP5x-EKZSyN35iThXw" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F1" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="Ie7eXix7-k292X7PtPkARg" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K8" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="xI6RykIU2kK08jxktusfOw" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K7" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="btwwwgMqSE2OtH01jzjfhg" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K6" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="AByiGovbj025VzCv5TLZrg" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K5" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="EU2slKHqiUOOgzVTzW1TRg" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K4" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="t9rVOzrB7UKbG1AnOlwd8w" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K3" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="7S6L_Avm80eQqYn2slV_3g" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K2" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="onULEVS-FEqAVnKZn6-UMg" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K1" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="Sg1WOp2N90-C5P06-KAn_g" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F3" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="aKSROhSaL0i6r-MR8SZyjw" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F2" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="Z7PxTx0_J02desojPzI61w" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K3" dim="Dimensionless" quantityType="0" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="eeAdPfYYM0WIjXmvSDPOKg" name="Lumen_coltrans_ColonTransversum_cell" description="Neighborhood between Lumen/Colon Transversum and Mucosa/Colon Transversum/Intracellular" mode="Logical" containerType="Other" firstNeighbor="0VK_KFeZDUK2wXtt8tiCFw" secondNeighbor="x1kSFFO9_kq-91UQyO7UCw">
-            <Tags>
-              <Tag value="Lumen_coltrans_ColonTransversum_cell" />
-              <Tag value="Neighborhood: ColonTransversum / Intracellular" />
-            </Tags>
-            <Children>
-              <Container id="VKKnbIHVQkG9rA53ZCYUYw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="aJSMsUmd_Uyw_yQNQ-DSHQ" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F2" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="ciWa4lfXmUO_bb5S25ag9g" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K2" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="OmI5DUVkMkG4bqQ0LiBXJQ" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K1" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="sPQBou2CrkaNn2k06V_XyA" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F3" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="zWKwZah780Odhbbxrcfr-Q" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F2" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="dJVUBRR0akqkZCfGOYxhNg" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F1" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="bBoJ6NacOkORiLJz55Cjaw" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K8" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="lrsluA0bRESFSi3EZyiaFw" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K7" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="-4slmTBaS0SGhMmfjlYiig" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K6" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="AJeD5cNEC0yfGOT4m2e00w" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K5" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="za5qMonGWEuV75DN6hG5Wg" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K4" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="8dieKz2LkE65Q4D1GRdS6Q" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K3" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="3nJpKdksCkq50-FbOmybKQ" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K2" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="so5JZh-YJkKVryhACctKhg" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F3" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="lLk0_j7yZECLDDJoBZw55w" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K5" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="2th8Sx4ptkWT0_wYi-OgRg" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F1" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="vDzoIh4pfEafpjcaXjhBpg" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_ColonTransversum" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="-6l9cjRGyEKpn2TtxwH7IQ" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_K_cell_pls_ColonTransversum" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="_patPXFW6EqgmmeMdhSrhA" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_lum_cell_factor" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="wEG72p9-OEGHbcn83UB0tw" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_cell_lum_factor" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="k9OJckUMvkaagj-sOZ6E1A" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_DrugAbsorption_trans" dim="Rate" quantityType="0" />
-                  <Parameter id="Yzf-ddQ3K0uSmnPz0YjrJQ" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K1" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="IKLdwiCkRUaR987MhBLhog" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K3" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="8e_FU-2YJU2N_iNVhlPk7Q" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K4" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="gynInRT1rUC8Z6RddeArfg" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K8" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="ISZcDX3TokyyB_Dh12lgkA" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K7" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="TQfsulV8sk2wxiATvsvzBQ" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K6" dim="Dimensionless" quantityType="0" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="jyBGv6t7cEyyoX75pu7iGA" name="Lumen_cae_Caecum_pls" description="Neighborhood between Lumen/Cecum and Mucosa/Cecum/Plasma" mode="Logical" containerType="Other" firstNeighbor="Tb_XB9kBdEijMjvfTLCFmg" secondNeighbor="CKUV4Ze6d0eoYQnRGiicug">
-            <Tags>
-              <Tag value="Lumen_cae_Caecum_pls" />
-              <Tag value="Neighborhood: Caecum / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="OTOMWRBJzUy7ZAy4DDWTZw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="2qWnwkYvQ0yrAc7r6nZ5tQ" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_DrugAbsorption_para" dim="Rate" quantityType="0" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="kSf8rG1-00iswGo8mbI80g" name="ColonTransversum_bc_PortalVein_bc" description="Neighborhood between Colon Transversum/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="k3eDZxhGcUSx99US8MzGjg" secondNeighbor="f1NQXRLB-0m-az7rPFpZXw">
-            <Tags>
-              <Tag value="ColonTransversum_bc_PortalVein_bc" />
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="cuSEGgdqd0a8Z4GkiohlCg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="powcQHljLE6U14jEERv0lw" name="Mass transfer rate (mucosa to portal vein blood cells)" description="Mass transfer rate (mucosa to portal vein blood cells)" persistable="0" isFixedValue="0" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPveBloodCells" dim="Rate" quantityType="0" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="JFr0Go6zyU2HXZ1lQIdoAw" name="Lumen_coldesc_ColonDescendens_pls" description="Neighborhood between Lumen/Colon Descendens and Mucosa/Colon Descendens/Plasma" mode="Logical" containerType="Other" firstNeighbor="hCfl5QSnmkScQGM_92IC7A" secondNeighbor="z4zcH_HhW0yr4B9Cwg_sfw">
-            <Tags>
-              <Tag value="Lumen_coldesc_ColonDescendens_pls" />
-              <Tag value="Neighborhood: ColonDescendens / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="OXeZQtEyzU6RrPrEp_ce0Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="LuLD9wH1r0moUHRFNI-JgA" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_DrugAbsorption_para" dim="Rate" quantityType="0" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="0ER-8hKLFUihGEQv5vhaJQ" name="Lumen_coldesc_ColonDescendens_cell" description="Neighborhood between Lumen/Colon Descendens and Mucosa/Colon Descendens/Intracellular" mode="Logical" containerType="Other" firstNeighbor="hCfl5QSnmkScQGM_92IC7A" secondNeighbor="vZZk3ffGfEecawifpPNcpA">
-            <Tags>
-              <Tag value="Lumen_coldesc_ColonDescendens_cell" />
-              <Tag value="Neighborhood: ColonDescendens / Intracellular" />
-            </Tags>
-            <Children>
-              <Container id="6InypfUHukGA-0MvJXDGqg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="cD2kVIlHG0SlKluJAcFz3w" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K8" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="2JIF9Le960CHqNefVZky7w" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_DrugAbsorption_trans" dim="Rate" quantityType="0" />
-                  <Parameter id="K0CEw2VETEmhfxd7Vha_iQ" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K6" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="0csUzyqXE02aRsp4QAAzrg" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K5" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="Ua2uuI2c5EGKafVSsSUJrg" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K4" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="kUHyLfsShU-hxrW5lXJGkg" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K3" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="YRZYuPr0tEmItlOSCrYW_g" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K2" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="ztkdFfltXkONGPkaIIrvAg" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K1" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="YHCuTNnKckewbpDU-soOVg" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F3" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="TkORusjBxUSXD8sD1mmE0w" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F2" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="y5XvNQTBbk6sitA99QW2AQ" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F1" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="yaLdO5SObUOGP-4BCE8dNQ" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_ColonDescendens" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="CQhRdIPqjEiF92fCC2LTBA" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_K_cell_pls_ColonDescendens" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="sVh2Ys8cL0-gfS-c6AP4Dg" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_cell_lum_factor" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="TEmRGBtQW0y4uMk3eJdGYQ" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_lum_cell_factor" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="R-8hil8Xm0-551FmwhbFFw" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F1" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="qqLQMM1Xo02VbdaEOb_Msg" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K7" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="_qO9sjIRgEqSKwLVDhXsTA" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K8" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="PxoiWRaTOkKp5I-bPHe-7Q" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K7" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="j0-KvlunZ0ej2a2djRvwbw" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K6" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="Wgl72eEAq0OHQjwcas0F8g" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K5" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="ngnZKbE9RU6S79gK5sKojw" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K4" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="_P5v3_NYVkarvTq23pieSw" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K3" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="aQQm_55oNk6Rb1vvMUHh3w" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K2" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="PpK4h2KMnE69nA5BmLSzCg" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K1" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="FJ09hJFTukuH5aw0im7L7A" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F3" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="rWxnTAQWRECjdkJWUEE7Ag" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F2" dim="Dimensionless" quantityType="0" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="v4kQH1UAQ0mmVHBW_DAPvA" name="ColonDescendens_pls_PortalVein_pls" description="Neighborhood between Colon Descendens/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="z4zcH_HhW0yr4B9Cwg_sfw" secondNeighbor="w0IqwDHp6UGv317_8RFz7w">
-            <Tags>
-              <Tag value="ColonDescendens_pls_PortalVein_pls" />
-              <Tag value="Neighborhood: Plasma / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="j_iHgdbMhEif-SBUuiAUWQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="cqzRiXvXPEWtc6ArGi1lDA" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" persistable="0" isFixedValue="0" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPvePlasma" dim="Rate" quantityType="0" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="HzI1hh72nUq0dXEnJ-6nbw" name="ColonDescendens_bc_PortalVein_bc" description="Neighborhood between Colon Descendens/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="XK3vUE0RlU2Uq4VMEUyDFQ" secondNeighbor="f1NQXRLB-0m-az7rPFpZXw">
-            <Tags>
-              <Tag value="ColonDescendens_bc_PortalVein_bc" />
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="-NHgCcWz3EaN79QgNJvqGQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="voty1AJkPEG43kib9tpPIg" name="Mass transfer rate (mucosa to portal vein blood cells)" description="Mass transfer rate (mucosa to portal vein blood cells)" persistable="0" isFixedValue="0" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPveBloodCells" dim="Rate" quantityType="0" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="qZJJukOoG0m0VrjJmi7Yww" name="Lumen_coltrans_ColonTransversum_pls" description="Neighborhood between Lumen/Colon Transversum and Mucosa/Colon Transversum/Plasma" mode="Logical" containerType="Other" firstNeighbor="0VK_KFeZDUK2wXtt8tiCFw" secondNeighbor="iPvRkWZ76UCcWPzFPJlJxQ">
-            <Tags>
-              <Tag value="Lumen_coltrans_ColonTransversum_pls" />
-              <Tag value="Neighborhood: ColonTransversum / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="Ua4K8sTq2Ei0PpB4bfE3Yw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="lnyq-8tX8EeVyhlCbHM9Vg" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_DrugAbsorption_para" dim="Rate" quantityType="0" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="BnbmO6gh6kaVMeU5NpnREA" name="Caecum_pls_PortalVein_pls" description="Neighborhood between Cecum/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="CKUV4Ze6d0eoYQnRGiicug" secondNeighbor="w0IqwDHp6UGv317_8RFz7w">
-            <Tags>
-              <Tag value="Caecum_pls_PortalVein_pls" />
-              <Tag value="Neighborhood: Plasma / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="aVtA8x_MjkS1gAoslUb6jQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="F8fUMIem3ESgWtSJy94hBg" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" persistable="0" isFixedValue="0" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPvePlasma" dim="Rate" quantityType="0" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="mfFtqXkNc0W2Y17-xNuYOw" name="ColonSigmoid_pls_PortalVein_pls" description="Neighborhood between Colon Sigmoid/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="FyoEzv-8O0WMSz47wtJ9gg" secondNeighbor="w0IqwDHp6UGv317_8RFz7w">
-            <Tags>
-              <Tag value="ColonSigmoid_pls_PortalVein_pls" />
-              <Tag value="Neighborhood: Plasma / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="p1z-v7A66kW_33I-7JBGsA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="J1qLklzJnU2bbXgX6PvpGw" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" persistable="0" isFixedValue="0" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPvePlasma" dim="Rate" quantityType="0" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="VYb3YtTybEazE_AN2UjYQA" name="Lumen_duo_Duodenum_pls" description="Neighborhood between Lumen/Duodenum and Mucosa/Duodenum/Plasma" mode="Logical" containerType="Other" firstNeighbor="0GDB2v61NEaYOE7qtRF98A" secondNeighbor="Uw8BHY6NWESXphEVCwU2-Q">
-            <Tags>
-              <Tag value="Lumen_duo_Duodenum_pls" />
-              <Tag value="Neighborhood: Duodenum / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="1C6_GudV0EuMnXnvAhFbVw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="NgA3Tb4abU6buOFS-HAsyg" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_DrugAbsorption_para" dim="Rate" quantityType="0" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="xTBGf5u0MkyjgKUA48fyzQ" name="Lumen_duo_Duodenum_cell" description="Neighborhood between Lumen/Duodenum and Mucosa/Duodenum/Intracellular" mode="Logical" containerType="Other" firstNeighbor="0GDB2v61NEaYOE7qtRF98A" secondNeighbor="Ky1ukmcECUWZ1yd2GXs5Yg">
-            <Tags>
-              <Tag value="Lumen_duo_Duodenum_cell" />
-              <Tag value="Neighborhood: Duodenum / Intracellular" />
-            </Tags>
-            <Children>
-              <Container id="Nd5SVmPCJE643RbI3f7nMg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="J0IgSrFXcki96eHHVqskEg" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K4" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="LfLA7q8eeUW1M_dUsY8i6g" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K4" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="RPd89ngMEEmfCqoDGEXSeA" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K5" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="FuSAXFknbUCfq-yRcf0V1w" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K6" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="yX3P4L_-cUiLJnVT2ZR6iw" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K7" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="2I7lDQ8WWEGPDK6GqBiNbA" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K8" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="PU-Bqf87Rkmchan6k63Qcw" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F1" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="VQYVPVZTdU-fpGRqI7k4HA" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F2" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="jT2FBq8UGEqQmC5vtwpV5w" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F3" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="TuXfHkLpFkSIBne309ISZw" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K1" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="Ef6ILt5xL0mDu4LvDFksFg" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K2" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="nLEa-dPDq0iJvEJ6ecFeWQ" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K3" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="JRIFWgvKfEep7QnY8MPrlQ" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K1" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="7F4zUmeA0UGjCz6xpEjVRw" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K5" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="hrdETs7AZ0K9TjWkAON45A" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K6" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="-KVrt8zb0UuJbA-uViFyDQ" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K7" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="chRm6F20BEGQK_sjOKG4RQ" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K8" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="TvBXKJbfukKkwGxaqsZf-w" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K2" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="5K0xI0pw8UCfXPJIlMmB6Q" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K3" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="ne658pE0ukO4_Shc7pstJg" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_DrugAbsorption_trans" dim="Rate" quantityType="0" />
-                  <Parameter id="zc4oeyntKUykvVrKM3kDHA" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_cell_lum_factor" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="gEY3sbdHGE-MvgdvknuCyA" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_lum_cell_factor" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="-jI7lyavY0uh722rE719NA" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_K_cell_pls_Duodenum" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="m23rO091aEuKza5rI1BoFw" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" formula="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_Duodenum" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="gKarvxoBKkyJl-4Y2JUn1g" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F1" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="yEHaLEWw_0W7uSWt4yMVFw" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F2" dim="Dimensionless" quantityType="0" />
-                  <Parameter id="DKDmyXHElU2bmB6DwXRypw" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F3" dim="Dimensionless" quantityType="0" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="055WVTyyHE-93lEmzbkN4g" name="Duodenum_pls_PortalVein_pls" description="Neighborhood between Duodenum/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="Uw8BHY6NWESXphEVCwU2-Q" secondNeighbor="w0IqwDHp6UGv317_8RFz7w">
-            <Tags>
-              <Tag value="Duodenum_pls_PortalVein_pls" />
-              <Tag value="Neighborhood: Plasma / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="zbxESWzLs0mS0z-rrb-Yvw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="Z2ebjOeYbEizlZJU4RgShQ" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" persistable="0" isFixedValue="0" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPvePlasma" dim="Rate" quantityType="0" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="ixd_VlmUfUGLZrtp1NL7vA" name="Duodenum_bc_PortalVein_bc" description="Neighborhood between Duodenum/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="pkv5-3lim0ytLpaYYc02Bg" secondNeighbor="f1NQXRLB-0m-az7rPFpZXw">
-            <Tags>
-              <Tag value="Duodenum_bc_PortalVein_bc" />
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="jiV9GpcAQU-wWIJcELrkSg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="knlRq1m5-EStmMJrXMFVsw" name="Mass transfer rate (mucosa to portal vein blood cells)" description="Mass transfer rate (mucosa to portal vein blood cells)" persistable="0" isFixedValue="0" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPveBloodCells" dim="Rate" quantityType="0" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="ihdGR-xkdk-Cu6b7g8X0gw" name="Lumen_colsigm_ColonSigmoid_pls" description="Neighborhood between Lumen/Colon Sigmoid and Mucosa/Colon Sigmoid/Plasma" mode="Logical" containerType="Other" firstNeighbor="Bi4ZMIHKqEWJTZaSDxNssw" secondNeighbor="FyoEzv-8O0WMSz47wtJ9gg">
-            <Tags>
-              <Tag value="Lumen_colsigm_ColonSigmoid_pls" />
-              <Tag value="Neighborhood: ColonSigmoid / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="dLBYvJTA1UqWt6ImM5dDnA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="9MxtRid9WUi8mQyAHF49HQ" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" formula="Lumen_PKSim.PARAM_DrugAbsorption_para" dim="Rate" quantityType="0" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="Shb2ikMIQUG1ZCsalOholg" name="ColonSigmoid_bc_PortalVein_bc" description="Neighborhood between Colon Sigmoid/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="Yo5tHCCFQUekhjV8Ghb7RQ" secondNeighbor="f1NQXRLB-0m-az7rPFpZXw">
-            <Tags>
-              <Tag value="ColonSigmoid_bc_PortalVein_bc" />
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="d0i2KzkheUeUKcRSQz_R_g" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
-                <Children>
-                  <Parameter id="FKHDwgspFEmT8tFyXsaVlg" name="Mass transfer rate (mucosa to portal vein blood cells)" description="Mass transfer rate (mucosa to portal vein blood cells)" persistable="0" isFixedValue="0" formula="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPveBloodCells" dim="Rate" quantityType="0" />
-                </Children>
-              </Container>
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="8QzTGZJDX0CZtN17JaB2kg" name="ArterialBlood_bc_Brain_bc" description="Neighborhood between Arterial Blood/Blood Cells and Brain/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="Q5cCzzKlnke4qkHZ8xor5Q" secondNeighbor="LnYylnnd70CKWWLhZ5wiiw">
-            <Tags>
-              <Tag value="ArterialBlood_bc_Brain_bc" />
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="cLymH5R4ZEaz4TbAB3y_DA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="lYvH6EhdP0iSMTucDupnTw" name="ArterialBlood_bc_Bone_bc" description="Neighborhood between Arterial Blood/Blood Cells and Bone/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="Q5cCzzKlnke4qkHZ8xor5Q" secondNeighbor="IdyTRgrwCk2h6V80mW3PDQ">
-            <Tags>
-              <Tag value="ArterialBlood_bc_Bone_bc" />
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="-cXe5_a7pUGcUxaPofG3bw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="q6zBfFLpr0m-0qDmxoDNaA" name="ArterialBlood_bc_Fat_bc" description="Neighborhood between Arterial Blood/Blood Cells and Fat/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="Q5cCzzKlnke4qkHZ8xor5Q" secondNeighbor="_oYSlCwAvEqqYY-nr9vV-A">
-            <Tags>
-              <Tag value="ArterialBlood_bc_Fat_bc" />
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="X82-jhBFzEaUBi6SbyZPLg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="bmUuwfLekkypamiER0Om7A" name="ArterialBlood_bc_Gonads_bc" description="Neighborhood between Arterial Blood/Blood Cells and Gonads/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="Q5cCzzKlnke4qkHZ8xor5Q" secondNeighbor="eaIswCZLm0uzQT4GU7uRVA">
-            <Tags>
-              <Tag value="ArterialBlood_bc_Gonads_bc" />
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="JVBeod4Ej0GBzTe0WUo6Pw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="bYgtsYRRQ0uw3xLMd7q-ug" name="ArterialBlood_bc_Heart_bc" description="Neighborhood between Arterial Blood/Blood Cells and Heart/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="Q5cCzzKlnke4qkHZ8xor5Q" secondNeighbor="6CFlcb_lrU6luBMQ8jh8fg">
-            <Tags>
-              <Tag value="ArterialBlood_bc_Heart_bc" />
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="khWsBB7DSkmy86-E3qVbSg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="T3AIE26qXEuMqUq0UUe8Lw" name="ArterialBlood_bc_Kidney_bc" description="Neighborhood between Arterial Blood/Blood Cells and Kidney/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="Q5cCzzKlnke4qkHZ8xor5Q" secondNeighbor="t7OB_yOuqEKWnXRIgdzF5w">
-            <Tags>
-              <Tag value="ArterialBlood_bc_Kidney_bc" />
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="RLd_-H09o0CZ4gqo21GstA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="woLQW5hYUUyc-OCRYB9l4w" name="ArterialBlood_bc_LargeIntestine_bc" description="Neighborhood between Arterial Blood/Blood Cells and Large Intestine/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="Q5cCzzKlnke4qkHZ8xor5Q" secondNeighbor="4VlXh1FvuEi4iThCgPo84g">
-            <Tags>
-              <Tag value="ArterialBlood_bc_LargeIntestine_bc" />
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="ot3c6QCQvUupXZ3vn-LUxA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="SsMZxohHIUiN53eW0uX67A" name="ArterialBlood_bc_Liver_bc" description="Neighborhood between Arterial Blood/Blood Cells and Liver/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="Q5cCzzKlnke4qkHZ8xor5Q" secondNeighbor="XysqfO-qtUmc2ATdlw_i7w">
-            <Tags>
-              <Tag value="ArterialBlood_bc_Liver_bc" />
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="8sB3hI8rZU2Lar_Tukt7zQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="frrlrV84Ekqyy-9sHcBdHg" name="ArterialBlood_bc_Skin_bc" description="Neighborhood between Arterial Blood/Blood Cells and Skin/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="Q5cCzzKlnke4qkHZ8xor5Q" secondNeighbor="qvC9N1AfkEK8pOJosYCAXA">
-            <Tags>
-              <Tag value="ArterialBlood_bc_Skin_bc" />
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="lRotUP0TJk-MX37x3BWakQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="RJ1Ah79NTUGyyPFm1fpedQ" name="ArterialBlood_bc_Muscle_bc" description="Neighborhood between Arterial Blood/Blood Cells and Muscle/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="Q5cCzzKlnke4qkHZ8xor5Q" secondNeighbor="eK9VyfeChkylRBoB9HqkvQ">
-            <Tags>
-              <Tag value="ArterialBlood_bc_Muscle_bc" />
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="msWpVX_EmU6n2yWSbShPMw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="iC1U_NEFokCAPxV4rhZvuA" name="ArterialBlood_pls_SmallIntestine_pls" description="Neighborhood between Arterial Blood/Plasma and Small Intestine/Plasma" mode="Logical" containerType="Other" firstNeighbor="CcmyB0FGkEKvncpso4EAvQ" secondNeighbor="9bNBf7f5bECO2rVlpa9ohg">
-            <Tags>
-              <Tag value="ArterialBlood_pls_SmallIntestine_pls" />
-              <Tag value="Neighborhood: Plasma / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="HNZG7RZo30CfNR8s69NiqA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="X9k0qQKF-U-d-i_Wx5ceBg" name="ArterialBlood_pls_Heart_pls" description="Neighborhood between Arterial Blood/Plasma and Heart/Plasma" mode="Logical" containerType="Other" firstNeighbor="CcmyB0FGkEKvncpso4EAvQ" secondNeighbor="XAQdPJN_Z02jzlcPJL4q9Q">
-            <Tags>
-              <Tag value="ArterialBlood_pls_Heart_pls" />
-              <Tag value="Neighborhood: Plasma / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="Rno8P6neJE-EyaHpgxWfrA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="u9A8psbMykmAq3xACz10ag" name="ArterialBlood_bc_SmallIntestine_bc" description="Neighborhood between Arterial Blood/Blood Cells and Small Intestine/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="Q5cCzzKlnke4qkHZ8xor5Q" secondNeighbor="aSoZ2sizDky7iyqNn7-KEg">
-            <Tags>
-              <Tag value="ArterialBlood_bc_SmallIntestine_bc" />
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="2SIXQJ11FkCrFW7HY8736w" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="h4Df4DbVdkSRUHb3Wj41VA" name="ArterialBlood_bc_Spleen_bc" description="Neighborhood between Arterial Blood/Blood Cells and Spleen/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="Q5cCzzKlnke4qkHZ8xor5Q" secondNeighbor="kHaRuNvhZU2sFR-n9sC5oQ">
-            <Tags>
-              <Tag value="ArterialBlood_bc_Spleen_bc" />
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="wgNc1glzHkmdVdgl-jY1tw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="2qQrS-E1kkKfdiewFr-2ew" name="ArterialBlood_bc_Stomach_bc" description="Neighborhood between Arterial Blood/Blood Cells and Stomach/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="Q5cCzzKlnke4qkHZ8xor5Q" secondNeighbor="6rJ8cqge0U28pltXPlJSGg">
-            <Tags>
-              <Tag value="ArterialBlood_bc_Stomach_bc" />
-              <Tag value="Neighborhood: BloodCells / BloodCells" />
-            </Tags>
-            <Children>
-              <Container id="wxSEEJn7uUar89RHrbNqJQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
-          <NeighborhoodBuilder id="YJ4A2TGsik2EzXMs_6Q-hQ" name="ArterialBlood_pls_Bone_pls" description="Neighborhood between Arterial Blood/Plasma and Bone/Plasma" mode="Logical" containerType="Other" firstNeighbor="CcmyB0FGkEKvncpso4EAvQ" secondNeighbor="1QX1qBETMkegE2iTSbuxZw">
-            <Tags>
-              <Tag value="ArterialBlood_pls_Bone_pls" />
-              <Tag value="Neighborhood: Plasma / Plasma" />
-            </Tags>
-            <Children>
-              <Container id="LzfSTrXB1US0CkwmGIM1cQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
-            </Children>
-          </NeighborhoodBuilder>
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-              <Tag value="LowerJejunum_cell__VenousBlood_pls" />
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-              <Path path="52" as="53" dim="21" />
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-              <Path path="42" as="43" dim="21" />
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-              <Path path="78" as="79" />
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-              <Path path="80" as="81" />
-              <Path path="48" as="49" dim="21" />
-              <Path path="82" as="83" />
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-              <Path path="52" as="53" dim="21" />
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-            <Paths>
-              <Path path="86" as="87" dim="87" />
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-            <Paths>
-              <Path path="88" as="89" dim="90" />
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-            <Paths>
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-              <Path path="96" as="97" dim="21" />
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-          </Formula>
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-            </Paths>
-          </Formula>
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-              <TimePath />
-            </Paths>
-          </Formula>
-          <Formula id="Individual_PKSim.PARAM_Q_from_Qspec" name="PARAM_Q_from_Qspec" dim="Dimensionless" formula="Qspec*Volume">
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-            </Paths>
-          </Formula>
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-            </Paths>
-          </Formula>
-          <Formula id="Individual_PKSim.PARAM_f_cell" name="PARAM_f_cell" dim="Dimensionless" formula="1 - f_int - f_vas">
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-            </Paths>
-          </Formula>
-          <Formula id="CompartmentsVolume_4Comp.VOLUME_pls_4Comp" name="VOLUME_pls_4Comp" dim="Volume" formula="f_vas*(1-HCT)*V_org">
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-          </Formula>
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-              <Path path="7" as="8" />
-            </Paths>
-          </Formula>
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-            </Paths>
-          </Formula>
-          <Formula id="Individual_PKSim.PARAM_pH_INT" name="PARAM_pH_INT" dim="Dimensionless" formula="pH_int">
-            <Paths>
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-            </Paths>
-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_bon" name="PARAM_K_Water_INT_bon" dim="Dimensionless" formula="K_water_int">
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-            </Paths>
-          </Formula>
-          <Formula id="CompoundCommon.PARAM_ProteinContainerVolume_Organ" name="PARAM_ProteinContainerVolume_Organ" dim="Volume" formula="Volume">
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-            </Paths>
-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_bon" name="PARAM_K_Water_CELL_bon" dim="Dimensionless" formula="K_water_cell">
-            <Paths>
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-            </Paths>
-          </Formula>
-          <Formula id="VascularEndoVolume.VOLUME_VascularEndo_brn" name="VOLUME_VascularEndo_brn" dim="Volume" formula="SA_pls_int*d_endo/1000">
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-          </Formula>
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-            <Paths>
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-          </Formula>
-          <Formula id="VascularEndoVolume.VOLUME_VascularEndo_tes" name="VOLUME_VascularEndo_tes" dim="Volume" formula="SA_pls_int*d_endo/1000">
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-          <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_tes" name="PARAM_K_Water_INT_tes" dim="Dimensionless" formula="K_water_int">
-            <Paths>
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-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_tes" name="PARAM_K_Water_CELL_tes" dim="Dimensionless" formula="K_water_cell">
-            <Paths>
-              <Path path="133" as="124" />
-            </Paths>
-          </Formula>
-          <Formula id="VascularEndoVolume.VOLUME_VascularEndo_hrt" name="VOLUME_VascularEndo_hrt" dim="Volume" formula="SA_pls_int*d_endo/1000">
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-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_hrt" name="PARAM_K_Water_INT_hrt" dim="Dimensionless" formula="K_water_int">
-            <Paths>
-              <Path path="135" as="120" />
-            </Paths>
-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_hrt" name="PARAM_K_Water_CELL_hrt" dim="Dimensionless" formula="K_water_cell">
-            <Paths>
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-            </Paths>
-          </Formula>
-          <Formula id="VascularEndoVolume.VOLUME_VascularEndo_kid" name="VOLUME_VascularEndo_kid" dim="Volume" formula="SA_pls_int*d_endo/1000">
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-            </Paths>
-          </Formula>
-          <Formula id="GFR_Calculation.PARAM_GFR_Spec" name="PARAM_GFR_Spec" dim="Dimensionless" formula="(PMA^Hill/(TM50^Hill+PMA^Hill)*(1-GFR_premat)+GFR_premat) * GFR_mat / V_kid_std">
-            <Paths>
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-            </Paths>
-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_kid" name="PARAM_K_Water_INT_kid" dim="Dimensionless" formula="K_water_int">
-            <Paths>
-              <Path path="152" as="120" />
-            </Paths>
-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_kid" name="PARAM_K_Water_CELL_kid" dim="Dimensionless" formula="K_water_cell">
-            <Paths>
-              <Path path="153" as="124" />
-            </Paths>
-          </Formula>
-          <Formula id="MucosaVolume.PARAM_VolumeGutWall" name="PARAM_VolumeGutWall" dim="Volume" formula="Area*d/1000">
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-            </Paths>
-          </Formula>
-          <Formula id="Lumen_PKSim.PARAM_FillLevel" name="PARAM_FillLevel" dim="Dimensionless" formula="Liquid/V">
-            <Paths>
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-              <Path path="93" as="97" dim="21" />
-            </Paths>
-          </Formula>
-          <Formula id="Lumen_PKSim.PARAM_FillLevelFlagFlag" name="PARAM_FillLevelFlagFlag" dim="Dimensionless" formula="(FillLevel&lt;0.9?1:1/(1+exp((FillLevel-1)/0.01)))">
-            <Paths>
-              <Path path="160" as="161" />
-            </Paths>
-          </Formula>
-          <Formula id="Lumen_PKSim.PARAM_Area" name="PARAM_Area" dim="Surface" formula="PI*(r1+r2)*L">
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-            </Paths>
-          </Formula>
-          <Formula id="Lumen_PKSim.PARAM_InverseGastricEmptyingTime" name="PARAM_InverseGastricEmptyingTime" dim="InversedTime" formula="1/GET">
-            <Paths>
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-            </Paths>
-          </Formula>
-          <Formula id="Lumen_PKSim.PARAM_Liquid_StartValue" name="PARAM_Liquid_StartValue" dim="Volume" formula="V*SteadyStateFillLevel">
-            <Paths>
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-              <Path path="93" as="97" dim="21" />
-            </Paths>
-          </Formula>
-          <Formula id="Lumen_PKSim.LiquidRHS_sto" name="LiquidRHS_sto" dim="Dimensionless" formula="OralApplicationsEnabled ? -LT_sto + Inflow*FillLevelFlag : 0">
-            <Paths>
-              <Path path="172" as="173" />
-              <Path path="174" as="175" dim="176" />
-              <Path path="177" as="178" dim="145" />
-              <Path path="179" as="180" />
-            </Paths>
-          </Formula>
-          <Formula id="Lumen_PKSim.PARAM_LiquidTransferRate_sto" name="PARAM_LiquidTransferRate_sto" dim="Rate" formula="w*Liquid*FillLevelFlagNext">
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-              <Path path="181" as="182" dim="90" />
-              <Path path="158" as="159" dim="21" />
-              <Path path="183" as="184" />
-            </Paths>
-          </Formula>
-          <Formula id="Lumen_PKSim.PARAM_pH_from_pH_fasted" name="PARAM_pH_from_pH_fasted" dim="Dimensionless" formula="pH_fasted">
-            <Paths>
-              <Path path="185" as="186" />
-            </Paths>
-          </Formula>
-          <Formula id="Lumen_PKSim.PARAM_Inflow_Stomach" name="PARAM_Inflow_Stomach" dim="Dimensionless" formula="SteadyStateFillLevel*V/StomachInflowTime">
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-              <Path path="187" as="188" dim="103" />
-              <Path path="93" as="97" dim="21" />
-              <TimePath />
-            </Paths>
-          </Formula>
-          <Formula id="CompartmentsVolume_4Comp.VOLUME_LumenSegment" name="VOLUME_LumenSegment" dim="Volume" formula="PI*(r1*r1+r1*r2+r2*r2)/3*L/1000">
-            <Paths>
-              <Path path="162" as="163" dim="15" />
-              <Path path="164" as="165" dim="15" />
-              <Path path="166" as="167" dim="15" />
-            </Paths>
-          </Formula>
-          <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F3" name="PARAM_pKa_pH_WS_lum_ForSol_F3" dim="Dimensionless" formula="CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1">
-            <Paths>
-              <Path path="189" as="190" />
-              <Path path="191" as="192" />
-              <Path path="193" as="194" />
-              <Path path="195" as="196" />
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-          </Formula>
-          <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F2" name="PARAM_pKa_pH_WS_lum_ForSol_F2" dim="Dimensionless" formula="CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1">
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-          </Formula>
-          <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_F1" name="PARAM_pKa_pH_WS_lum_ForSol_F1" dim="Dimensionless" formula="CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1">
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-              <Path path="201" as="202" />
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-              <Path path="195" as="196" />
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-          </Formula>
-          <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K3" name="PARAM_pKa_pH_WS_lum_ForSol_K3" dim="Dimensionless" formula="F1*(1-F2)*F3">
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-          <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K1" name="PARAM_pKa_pH_WS_lum_ForSol_K1" dim="Dimensionless" formula="F1*F2*F3">
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-          <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K2" name="PARAM_pKa_pH_WS_lum_ForSol_K2" dim="Dimensionless" formula="(1-F1)*F2*F3">
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-              <Path path="209" as="210" />
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-          </Formula>
-          <Formula id="CompoundAcidBase_PKSim.PARAM_Solubility_pKa_pH_Factor" name="PARAM_Solubility_pKa_pH_Factor" dim="Dimensionless" formula="K1+K2/base^(CT0^2)+K3/base^(CT1^2)+K4/base^(CT2^2)+K5/base^max(CT0+CT1;-CT0-CT1)+K6/base^max(CT0+CT2;-CT0-CT2)+K7/base^max(CT1+CT2;-CT1-CT2)+K8/base^max(CT0+CT1+CT2;-CT0-CT1-CT2)">
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-          <Formula id="Lumen_PKSim.PARAM_IntestinalSolubility" name="PARAM_IntestinalSolubility" dim="Concentration" formula="Solubility * Solubility_pKa_REFpH_Factor / Solubility_pKa_pH_Factor">
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-          <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K7" name="PARAM_pKa_pH_WS_lum_ForSol_K7" dim="Dimensionless" formula="F1*(1-F2)*(1-F3)">
-            <Paths>
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-              <Path path="207" as="208" />
-              <Path path="209" as="210" />
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-          </Formula>
-          <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K6" name="PARAM_pKa_pH_WS_lum_ForSol_K6" dim="Dimensionless" formula="(1-F1)*F2*(1-F3)">
-            <Paths>
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-              <Path path="207" as="208" />
-              <Path path="209" as="210" />
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-          </Formula>
-          <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K5" name="PARAM_pKa_pH_WS_lum_ForSol_K5" dim="Dimensionless" formula="(1-F1)*(1-F2)*F3">
-            <Paths>
-              <Path path="205" as="206" />
-              <Path path="207" as="208" />
-              <Path path="209" as="210" />
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-          </Formula>
-          <Formula id="CompoundAcidBase_PKSim.PARAM_pKa_pH_WS_lum_ForSol_K4" name="PARAM_pKa_pH_WS_lum_ForSol_K4" dim="Dimensionless" formula="F1*F2*(1-F3)">
-            <Paths>
-              <Path path="205" as="206" />
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-              <Path path="209" as="210" />
-            </Paths>
-          </Formula>
-          <Formula id="Lumen_Geometry.PARAM_Lumen_Geometry_R2" name="PARAM_Lumen_Geometry_R2" dim="Length" formula="r2_p0 + Height*r2_p1">
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-              <Path path="237" as="238" dim="15" />
-              <Path path="239" as="240" />
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-          </Formula>
-          <Formula id="Lumen_PKSim.PARAM_InverseSITT_Factor_Duodenum" name="PARAM_InverseSITT_Factor_Duodenum" dim="InversedTime" formula="LuminalVelocity/SITT_fact">
-            <Paths>
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-          </Formula>
-          <Formula id="Lumen_Geometry.PARAM_Lumen_Geometry_Length" name="PARAM_Lumen_Geometry_Length" dim="Length" formula="L_p0 + Height*L_p1">
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-              <Path path="245" as="246" dim="15" />
-              <Path path="247" as="248" />
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-          </Formula>
-          <Formula id="Lumen_PKSim.LiquidRHS_duo" name="LiquidRHS_duo" dim="Dimensionless" formula="OralApplicationsEnabled ? LT_sto - LT_duo + Inflow*FillLevelFlag - Outflow*Liquid : 0">
-            <Paths>
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-              <Path path="172" as="173" />
-              <Path path="158" as="159" dim="21" />
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-              <Path path="179" as="180" />
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-          </Formula>
-          <Formula id="Lumen_PKSim.PARAM_LiquidTransferRate_duo" name="PARAM_LiquidTransferRate_duo" dim="Rate" formula="w*Liquid*FillLevelFlagNext">
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-              <Path path="158" as="159" dim="21" />
-              <Path path="253" as="184" />
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-          </Formula>
-          <Formula id="Lumen_Geometry.PARAM_Lumen_Geometry_R1" name="PARAM_Lumen_Geometry_R1" dim="Length" formula="r1_p0 + Height*r1_p1">
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-          </Formula>
-          <Formula id="Lumen_Geometry.PARAM_Lumen_Geometry_Thickness" name="PARAM_Lumen_Geometry_Thickness" dim="Length" formula="Thickness_p1 + Thickness_p2*(1-exp(Thickness_p3*Height))">
-            <Paths>
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-              <Path path="260" as="261" dim="15" />
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-          </Formula>
-          <Formula id="Lumen_PKSim.PARAM_Inflow_Duodenum" name="PARAM_Inflow_Duodenum" dim="Dimensionless" formula="0.02894*V">
-            <Paths>
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-            </Paths>
-          </Formula>
-          <Formula id="Lumen_PKSim.PARAM_Outflow_Duodenum" name="PARAM_Outflow_Duodenum" dim="InversedTime" formula="(k_p*alpha_p*V_p+inflow-k*alpha*V)/(alpha*V)">
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-              <Path path="181" as="266" dim="90" />
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-              <Path path="270" as="271" dim="90" />
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-            </Paths>
-          </Formula>
-          <Formula id="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_duo" name="PARAM_OralMassAbsorbed_RHS_duo" dim="Rate" formula="DA_para_duo+DA_trans_duo">
-            <Paths>
-              <Path path="274" as="275" dim="176" />
-              <Path path="276" as="277" dim="176" />
-            </Paths>
-          </Formula>
-          <Formula id="Lumen_PKSim.PARAM_Outflow_UpperJejunum" name="PARAM_Outflow_UpperJejunum" dim="InversedTime" formula="(k_p*alpha_p*V_p+inflow-k*alpha*V)/(alpha*V)">
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-            </Paths>
-          </Formula>
-          <Formula id="Lumen_PKSim.PARAM_Outflow_Rectum" name="PARAM_Outflow_Rectum" dim="InversedTime" formula="(k_p*alpha_p*V_p+inflow-k*alpha*V)/(alpha*V)">
-            <Paths>
-              <Path path="170" as="265" dim="100" />
-              <Path path="181" as="266" dim="90" />
-              <Path path="177" as="267" dim="145" />
-              <Path path="93" as="97" dim="21" />
-              <Path path="370" as="269" dim="100" />
-              <Path path="371" as="271" dim="90" />
-              <Path path="372" as="273" dim="21" />
-            </Paths>
-          </Formula>
-          <Formula id="Lumen_PKSim.PARAM_InverseLITT_Factor_Rectum" name="PARAM_InverseLITT_Factor_Rectum" dim="InversedTime" formula="LuminalVelocity/LITT_fact">
-            <Paths>
-              <Path path="241" as="242" dim="90" />
-              <Path path="321" as="322" />
-            </Paths>
-          </Formula>
-          <Formula id="Lumen_PKSim.LiquidRHS_rect" name="LiquidRHS_rect" dim="Dimensionless" formula="OralApplicationsEnabled ? LT_colsigm - LT_rect + Inflow*FillLevelFlag : 0">
-            <Paths>
-              <Path path="172" as="173" />
-              <Path path="174" as="373" dim="176" />
-              <Path path="177" as="178" dim="145" />
-              <Path path="374" as="363" dim="176" />
-              <Path path="179" as="180" />
-            </Paths>
-          </Formula>
-          <Formula id="Lumen_PKSim.PARAM_LiquidTransferRate_rect" name="PARAM_LiquidTransferRate_rect" dim="Rate" formula="w*Liquid">
-            <Paths>
-              <Path path="181" as="182" dim="90" />
-              <Path path="158" as="159" dim="21" />
-            </Paths>
-          </Formula>
-          <Formula id="Lumen_PKSim.PARAM_Inflow_Rectum" name="PARAM_Inflow_Rectum" dim="Dimensionless" formula="0.00071247*V">
-            <Paths>
-              <Path path="93" as="97" dim="21" />
-            </Paths>
-          </Formula>
-          <Formula id="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS_rect" name="PARAM_OralMassAbsorbed_RHS_rect" dim="Rate" formula="DA_para_rect+DA_trans_rect">
-            <Paths>
-              <Path path="375" as="376" dim="176" />
-              <Path path="377" as="378" dim="176" />
-            </Paths>
-          </Formula>
-          <Formula id="Lumen_PKSim.LiquidRHS_fec" name="LiquidRHS_fec" dim="Dimensionless" formula="OralApplicationsEnabled ? LT_rec : 0">
-            <Paths>
-              <Path path="379" as="380" dim="176" />
-              <Path path="179" as="180" />
-            </Paths>
-          </Formula>
-          <Formula id="VascularEndoVolume.VOLUME_VascularEndo_sto" name="VOLUME_VascularEndo_sto" dim="Volume" formula="SA_pls_int*d_endo/1000">
-            <Paths>
-              <Path path="107" as="108" dim="15" />
-              <Path path="381" as="110" dim="111" />
-            </Paths>
-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_sto" name="PARAM_K_Water_INT_sto" dim="Dimensionless" formula="K_water_int">
-            <Paths>
-              <Path path="382" as="120" />
-            </Paths>
-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_sto" name="PARAM_K_Water_CELL_sto" dim="Dimensionless" formula="K_water_cell">
-            <Paths>
-              <Path path="383" as="124" />
-            </Paths>
-          </Formula>
-          <Formula id="Lumen_PKSim.PARAM_SITT_Factor" name="PARAM_SITT_Factor" dim="Dimensionless" formula="(Colon_Arrival_Time/60 - Colon_Arrival_Time_Intercept) / Colon_Arrival_Time_Slope">
-            <Paths>
-              <Path path="384" as="385" dim="103" />
-              <Path path="386" as="387" dim="103" />
-              <Path path="388" as="389" dim="103" />
-              <TimePath />
-            </Paths>
-          </Formula>
-          <Formula id="Lumen_PKSim.PARAM_Colon_Arrival_Time_Slope" name="PARAM_Colon_Arrival_Time_Slope" dim="Dimensionless" formula="a0 + a1*GET + a2*GET^2">
-            <Paths>
-              <Path path="390" as="391" dim="103" />
-              <Path path="392" as="393" />
-              <Path path="394" as="395" dim="90" />
-              <Path path="396" as="169" dim="103" />
-            </Paths>
-          </Formula>
-          <Formula id="Lumen_PKSim.PARAM_Colon_Arrival_Time_Intercept" name="PARAM_Colon_Arrival_Time_Intercept" dim="Time" formula="a0 + a1*GET">
-            <Paths>
-              <Path path="397" as="391" dim="103" />
-              <Path path="398" as="393" />
-              <Path path="396" as="169" dim="103" />
-            </Paths>
-          </Formula>
-          <Formula id="Individual_PKSim.PARAM_Q_Lymph_sin" name="PARAM_Q_Lymph_sin" dim="Dimensionless" formula="Q_lymph_incl_Mucosa-Q_lymph_duo-Q_lymph_uje-Q_lymph_lje-Q_lymph_uil-Q_lymph_lil">
-            <Paths>
-              <Path path="399" as="400" dim="145" />
-              <Path path="401" as="402" dim="145" />
-              <Path path="403" as="404" dim="145" />
-              <Path path="405" as="406" dim="145" />
-              <Path path="407" as="408" dim="145" />
-              <Path path="409" as="410" dim="145" />
-            </Paths>
-          </Formula>
-          <Formula id="VascularEndoVolume.VOLUME_VascularEndo_sin" name="VOLUME_VascularEndo_sin" dim="Volume" formula="SA_pls_int*d_endo/1000">
-            <Paths>
-              <Path path="107" as="108" dim="15" />
-              <Path path="411" as="110" dim="111" />
-            </Paths>
-          </Formula>
-          <Formula id="Individual_PKSim.PARAM_FluidRecirculationRate_sin" name="PARAM_FluidRecirculationRate_sin" dim="Dimensionless" formula="J_iso_incl_Mucosa-J_iso_duo-J_iso_uje-J_iso_lje-J_iso_uil-J_iso_lil">
-            <Paths>
-              <Path path="412" as="413" dim="145" />
-              <Path path="414" as="415" dim="145" />
-              <Path path="416" as="417" dim="145" />
-              <Path path="418" as="419" dim="145" />
-              <Path path="420" as="421" dim="145" />
-              <Path path="422" as="423" dim="145" />
-            </Paths>
-          </Formula>
-          <Formula id="MucosaVolume.VOLUME_SmallIntestineMucosa" name="VOLUME_SmallIntestineMucosa" dim="Volume" formula="V_duo+V_uje+V_lje+V_uil+V_lil">
-            <Paths>
-              <Path path="424" as="425" dim="21" />
-              <Path path="426" as="427" dim="21" />
-              <Path path="428" as="429" dim="21" />
-              <Path path="430" as="431" dim="21" />
-              <Path path="432" as="433" dim="21" />
-            </Paths>
-          </Formula>
-          <Formula id="CompartmentsVolume_4Comp.VOLUME_pls_SinLin" name="VOLUME_pls_SinLin" dim="Volume" formula="f_vas*(1-HCT)*(V-V_Mucosa)">
-            <Paths>
-              <Path path="94" as="95" />
-              <Path path="96" as="97" dim="21" />
-              <Path path="434" as="435" dim="21" />
-              <Path path="7" as="8" />
-            </Paths>
-          </Formula>
-          <Formula id="CompartmentsVolume_4Comp.VOLUME_bc_SinLin" name="VOLUME_bc_SinLin" dim="Volume" formula="f_vas*HCT*(V-V_Mucosa)">
-            <Paths>
-              <Path path="94" as="95" />
-              <Path path="96" as="97" dim="21" />
-              <Path path="434" as="435" dim="21" />
-              <Path path="7" as="8" />
-            </Paths>
-          </Formula>
-          <Formula id="CompartmentsVolume_4Comp.VOLUME_int_SinLin" name="VOLUME_int_SinLin" dim="Volume" formula="f_int*(V-V_Mucosa)">
-            <Paths>
-              <Path path="116" as="113" />
-              <Path path="96" as="97" dim="21" />
-              <Path path="434" as="435" dim="21" />
-            </Paths>
-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_sin" name="PARAM_K_Water_INT_sin" dim="Dimensionless" formula="K_water_int">
-            <Paths>
-              <Path path="436" as="120" />
-            </Paths>
-          </Formula>
-          <Formula id="CompoundCommon.PARAM_ProteinContainerVolume_Organ_SinLin" name="PARAM_ProteinContainerVolume_Organ_SinLin" dim="Volume" formula="Volume-V_Mucosa">
-            <Paths>
-              <Path path="96" as="21" dim="21" />
-              <Path path="434" as="435" dim="21" />
-            </Paths>
-          </Formula>
-          <Formula id="CompartmentsVolume_4Comp.VOLUME_cell_SinLin" name="VOLUME_cell_SinLin" dim="Volume" formula="f_cell*(V-V_Mucosa)">
-            <Paths>
-              <Path path="121" as="122" />
-              <Path path="96" as="97" dim="21" />
-              <Path path="434" as="435" dim="21" />
-            </Paths>
-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_sin" name="PARAM_K_Water_CELL_sin" dim="Dimensionless" formula="K_water_cell">
-            <Paths>
-              <Path path="437" as="124" />
-            </Paths>
-          </Formula>
-          <Formula id="MucosaVolume.VOLUME_MucosaDuodenum" name="VOLUME_MucosaDuodenum" dim="Volume" formula="V_GutWall*fractionMucosa">
-            <Paths>
-              <Path path="438" as="439" />
-              <Path path="440" as="441" dim="21" />
-            </Paths>
-          </Formula>
-          <Formula id="Individual_PKSim.PARAM_J_iso_Mucosa" name="PARAM_J_iso_Mucosa" dim="Dimensionless" formula="J_iso_intestine * V_seg / V_intestine">
-            <Paths>
-              <Path path="442" as="443" dim="145" />
-              <Path path="444" as="445" dim="21" />
-              <Path path="93" as="446" dim="21" />
-            </Paths>
-          </Formula>
-          <Formula id="Individual_PKSim.PARAM_Q_lymph_mucosa" name="PARAM_Q_lymph_mucosa" dim="Dimensionless" formula="Q_lymph_intestine * V_seg / V_intestine">
-            <Paths>
-              <Path path="447" as="448" dim="145" />
-              <Path path="444" as="445" dim="21" />
-              <Path path="93" as="446" dim="21" />
-            </Paths>
-          </Formula>
-          <Formula id="VascularEndoVolume.VOLUME_VascularEndo_duo" name="VOLUME_VascularEndo_duo" dim="Volume" formula="SA_pls_int*d_endo/1000">
-            <Paths>
-              <Path path="107" as="108" dim="15" />
-              <Path path="449" as="110" dim="111" />
-            </Paths>
-          </Formula>
-          <Formula id="Individual_PKSim.PARAM_Q_mucosa" name="PARAM_Q_mucosa" dim="Dimensionless" formula="Q * fractQ * regionalFractQ">
-            <Paths>
-              <Path path="450" as="451" dim="145" />
-              <Path path="452" as="453" />
-              <Path path="454" as="455" />
-            </Paths>
-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_duo" name="PARAM_K_Water_INT_duo" dim="Dimensionless" formula="K_water_int">
-            <Paths>
-              <Path path="456" as="120" />
-            </Paths>
-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_duo" name="PARAM_K_Water_CELL_duo" dim="Dimensionless" formula="K_water_cell">
-            <Paths>
-              <Path path="457" as="124" />
-            </Paths>
-          </Formula>
-          <Formula id="MucosaVolume.VOLUME_MucosaUpperJejunum" name="VOLUME_MucosaUpperJejunum" dim="Volume" formula="V_GutWall*fractionMucosa">
-            <Paths>
-              <Path path="438" as="439" />
-              <Path path="458" as="441" dim="21" />
-            </Paths>
-          </Formula>
-          <Formula id="VascularEndoVolume.VOLUME_VascularEndo_uje" name="VOLUME_VascularEndo_uje" dim="Volume" formula="SA_pls_int*d_endo/1000">
-            <Paths>
-              <Path path="107" as="108" dim="15" />
-              <Path path="459" as="110" dim="111" />
-            </Paths>
-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_uje" name="PARAM_K_Water_INT_uje" dim="Dimensionless" formula="K_water_int">
-            <Paths>
-              <Path path="460" as="120" />
-            </Paths>
-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_uje" name="PARAM_K_Water_CELL_uje" dim="Dimensionless" formula="K_water_cell">
-            <Paths>
-              <Path path="461" as="124" />
-            </Paths>
-          </Formula>
-          <Formula id="MucosaVolume.VOLUME_MucosaLowerJejunum" name="VOLUME_MucosaLowerJejunum" dim="Volume" formula="V_GutWall*fractionMucosa">
-            <Paths>
-              <Path path="438" as="439" />
-              <Path path="462" as="441" dim="21" />
-            </Paths>
-          </Formula>
-          <Formula id="VascularEndoVolume.VOLUME_VascularEndo_lje" name="VOLUME_VascularEndo_lje" dim="Volume" formula="SA_pls_int*d_endo/1000">
-            <Paths>
-              <Path path="107" as="108" dim="15" />
-              <Path path="463" as="110" dim="111" />
-            </Paths>
-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_lje" name="PARAM_K_Water_INT_lje" dim="Dimensionless" formula="K_water_int">
-            <Paths>
-              <Path path="464" as="120" />
-            </Paths>
-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_lje" name="PARAM_K_Water_CELL_lje" dim="Dimensionless" formula="K_water_cell">
-            <Paths>
-              <Path path="465" as="124" />
-            </Paths>
-          </Formula>
-          <Formula id="MucosaVolume.VOLUME_MucosaUpperIleum" name="VOLUME_MucosaUpperIleum" dim="Volume" formula="V_GutWall*fractionMucosa">
-            <Paths>
-              <Path path="438" as="439" />
-              <Path path="466" as="441" dim="21" />
-            </Paths>
-          </Formula>
-          <Formula id="VascularEndoVolume.VOLUME_VascularEndo_uil" name="VOLUME_VascularEndo_uil" dim="Volume" formula="SA_pls_int*d_endo/1000">
-            <Paths>
-              <Path path="107" as="108" dim="15" />
-              <Path path="467" as="110" dim="111" />
-            </Paths>
-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_uil" name="PARAM_K_Water_INT_uil" dim="Dimensionless" formula="K_water_int">
-            <Paths>
-              <Path path="468" as="120" />
-            </Paths>
-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_uil" name="PARAM_K_Water_CELL_uil" dim="Dimensionless" formula="K_water_cell">
-            <Paths>
-              <Path path="469" as="124" />
-            </Paths>
-          </Formula>
-          <Formula id="MucosaVolume.VOLUME_MucosaLowerIleum" name="VOLUME_MucosaLowerIleum" dim="Volume" formula="V_GutWall*fractionMucosa">
-            <Paths>
-              <Path path="438" as="439" />
-              <Path path="470" as="441" dim="21" />
-            </Paths>
-          </Formula>
-          <Formula id="VascularEndoVolume.VOLUME_VascularEndo_lil" name="VOLUME_VascularEndo_lil" dim="Volume" formula="SA_pls_int*d_endo/1000">
-            <Paths>
-              <Path path="107" as="108" dim="15" />
-              <Path path="471" as="110" dim="111" />
-            </Paths>
-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_lil" name="PARAM_K_Water_INT_lil" dim="Dimensionless" formula="K_water_int">
-            <Paths>
-              <Path path="472" as="120" />
-            </Paths>
-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_lil" name="PARAM_K_Water_CELL_lil" dim="Dimensionless" formula="K_water_cell">
-            <Paths>
-              <Path path="473" as="124" />
-            </Paths>
-          </Formula>
-          <Formula id="Lumen_PKSim.PARAM_LITT_Factor" name="PARAM_LITT_Factor" dim="Dimensionless" formula="(Excretion_Time/60 - Excretion_Time_k0 - Excretion_Time_k2 * Colon_Arrival_Time/60) / Excretion_Time_k1">
-            <Paths>
-              <Path path="474" as="475" dim="103" />
-              <Path path="476" as="477" dim="103" />
-              <Path path="478" as="479" dim="103" />
-              <Path path="480" as="481" />
-              <Path path="482" as="385" dim="103" />
-              <TimePath />
-            </Paths>
-          </Formula>
-          <Formula id="MucosaVolume.VOLUME_LargeIntestineMucosa" name="VOLUME_LargeIntestineMucosa" dim="Volume" formula="V_cae+V_ca+V_ct+V_cd+V_cs+V_rec">
-            <Paths>
-              <Path path="483" as="484" dim="21" />
-              <Path path="485" as="486" dim="21" />
-              <Path path="487" as="488" dim="21" />
-              <Path path="489" as="490" dim="21" />
-              <Path path="491" as="492" dim="21" />
-              <Path path="493" as="494" dim="21" />
-            </Paths>
-          </Formula>
-          <Formula id="VascularEndoVolume.VOLUME_VascularEndo_lin" name="VOLUME_VascularEndo_lin" dim="Volume" formula="SA_pls_int*d_endo/1000">
-            <Paths>
-              <Path path="107" as="108" dim="15" />
-              <Path path="495" as="110" dim="111" />
-            </Paths>
-          </Formula>
-          <Formula id="Individual_PKSim.PARAM_Q_Lymph_lin" name="PARAM_Q_Lymph_lin" dim="Dimensionless" formula="Q_lymph_incl_Mucosa-Q_lymph_cae-Q_lymph_colasc-Q_lymph_coltrans-Q_lymph_coldesc-Q_lymph_colsigm-Q_lymph_rect">
-            <Paths>
-              <Path path="399" as="400" dim="145" />
-              <Path path="496" as="497" dim="145" />
-              <Path path="498" as="499" dim="145" />
-              <Path path="500" as="501" dim="145" />
-              <Path path="502" as="503" dim="145" />
-              <Path path="504" as="505" dim="145" />
-              <Path path="506" as="507" dim="145" />
-            </Paths>
-          </Formula>
-          <Formula id="Individual_PKSim.PARAM_FluidRecirculationRate_lin" name="PARAM_FluidRecirculationRate_lin" dim="Dimensionless" formula="J_iso_incl_Mucosa-J_iso_cae-J_iso_colasc-J_iso_coltrans-J_iso_coldesc-J_iso_colsigm-J_iso_rect">
-            <Paths>
-              <Path path="412" as="413" dim="145" />
-              <Path path="508" as="509" dim="145" />
-              <Path path="510" as="511" dim="145" />
-              <Path path="512" as="513" dim="145" />
-              <Path path="514" as="515" dim="145" />
-              <Path path="516" as="517" dim="145" />
-              <Path path="518" as="519" dim="145" />
-            </Paths>
-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_lin" name="PARAM_K_Water_INT_lin" dim="Dimensionless" formula="K_water_int">
-            <Paths>
-              <Path path="520" as="120" />
-            </Paths>
-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_lin" name="PARAM_K_Water_CELL_lin" dim="Dimensionless" formula="K_water_cell">
-            <Paths>
-              <Path path="521" as="124" />
-            </Paths>
-          </Formula>
-          <Formula id="MucosaVolume.VOLUME_MucosaCaecum" name="VOLUME_MucosaCaecum" dim="Volume" formula="V_GutWall*fractionMucosa">
-            <Paths>
-              <Path path="438" as="439" />
-              <Path path="522" as="441" dim="21" />
-            </Paths>
-          </Formula>
-          <Formula id="VascularEndoVolume.VOLUME_VascularEndo_cae" name="VOLUME_VascularEndo_cae" dim="Volume" formula="SA_pls_int*d_endo/1000">
-            <Paths>
-              <Path path="107" as="108" dim="15" />
-              <Path path="523" as="110" dim="111" />
-            </Paths>
-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_cae" name="PARAM_K_Water_INT_cae" dim="Dimensionless" formula="K_water_int">
-            <Paths>
-              <Path path="524" as="120" />
-            </Paths>
-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_cae" name="PARAM_K_Water_CELL_cae" dim="Dimensionless" formula="K_water_cell">
-            <Paths>
-              <Path path="525" as="124" />
-            </Paths>
-          </Formula>
-          <Formula id="MucosaVolume.VOLUME_MucosaColonAscendens" name="VOLUME_MucosaColonAscendens" dim="Volume" formula="V_GutWall*fractionMucosa">
-            <Paths>
-              <Path path="438" as="439" />
-              <Path path="526" as="441" dim="21" />
-            </Paths>
-          </Formula>
-          <Formula id="VascularEndoVolume.VOLUME_VascularEndo_colasc" name="VOLUME_VascularEndo_colasc" dim="Volume" formula="SA_pls_int*d_endo/1000">
-            <Paths>
-              <Path path="107" as="108" dim="15" />
-              <Path path="527" as="110" dim="111" />
-            </Paths>
-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_colasc" name="PARAM_K_Water_INT_colasc" dim="Dimensionless" formula="K_water_int">
-            <Paths>
-              <Path path="528" as="120" />
-            </Paths>
-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_colasc" name="PARAM_K_Water_CELL_colasc" dim="Dimensionless" formula="K_water_cell">
-            <Paths>
-              <Path path="529" as="124" />
-            </Paths>
-          </Formula>
-          <Formula id="MucosaVolume.VOLUME_MucosaColonTransversum" name="VOLUME_MucosaColonTransversum" dim="Volume" formula="V_GutWall*fractionMucosa">
-            <Paths>
-              <Path path="438" as="439" />
-              <Path path="530" as="441" dim="21" />
-            </Paths>
-          </Formula>
-          <Formula id="VascularEndoVolume.VOLUME_VascularEndo_coltrans" name="VOLUME_VascularEndo_coltrans" dim="Volume" formula="SA_pls_int*d_endo/1000">
-            <Paths>
-              <Path path="107" as="108" dim="15" />
-              <Path path="531" as="110" dim="111" />
-            </Paths>
-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_coltrans" name="PARAM_K_Water_INT_coltrans" dim="Dimensionless" formula="K_water_int">
-            <Paths>
-              <Path path="532" as="120" />
-            </Paths>
-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_coltrans" name="PARAM_K_Water_CELL_coltrans" dim="Dimensionless" formula="K_water_cell">
-            <Paths>
-              <Path path="533" as="124" />
-            </Paths>
-          </Formula>
-          <Formula id="MucosaVolume.VOLUME_MucosaColonDescendens" name="VOLUME_MucosaColonDescendens" dim="Volume" formula="V_GutWall*fractionMucosa">
-            <Paths>
-              <Path path="438" as="439" />
-              <Path path="534" as="441" dim="21" />
-            </Paths>
-          </Formula>
-          <Formula id="VascularEndoVolume.VOLUME_VascularEndo_coldesc" name="VOLUME_VascularEndo_coldesc" dim="Volume" formula="SA_pls_int*d_endo/1000">
-            <Paths>
-              <Path path="107" as="108" dim="15" />
-              <Path path="535" as="110" dim="111" />
-            </Paths>
-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_coldesc" name="PARAM_K_Water_INT_coldesc" dim="Dimensionless" formula="K_water_int">
-            <Paths>
-              <Path path="536" as="120" />
-            </Paths>
-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_coldesc" name="PARAM_K_Water_CELL_coldesc" dim="Dimensionless" formula="K_water_cell">
-            <Paths>
-              <Path path="537" as="124" />
-            </Paths>
-          </Formula>
-          <Formula id="MucosaVolume.VOLUME_MucosaColonSigmoid" name="VOLUME_MucosaColonSigmoid" dim="Volume" formula="V_GutWall*fractionMucosa">
-            <Paths>
-              <Path path="438" as="439" />
-              <Path path="538" as="441" dim="21" />
-            </Paths>
-          </Formula>
-          <Formula id="VascularEndoVolume.VOLUME_VascularEndo_colsigm" name="VOLUME_VascularEndo_colsigm" dim="Volume" formula="SA_pls_int*d_endo/1000">
-            <Paths>
-              <Path path="107" as="108" dim="15" />
-              <Path path="539" as="110" dim="111" />
-            </Paths>
-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_colsigm" name="PARAM_K_Water_INT_colsigm" dim="Dimensionless" formula="K_water_int">
-            <Paths>
-              <Path path="540" as="120" />
-            </Paths>
-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_colsigm" name="PARAM_K_Water_CELL_colsigm" dim="Dimensionless" formula="K_water_cell">
-            <Paths>
-              <Path path="541" as="124" />
-            </Paths>
-          </Formula>
-          <Formula id="MucosaVolume.VOLUME_MucosaRectum" name="VOLUME_MucosaRectum" dim="Volume" formula="V_GutWall*fractionMucosa">
-            <Paths>
-              <Path path="438" as="439" />
-              <Path path="542" as="441" dim="21" />
-            </Paths>
-          </Formula>
-          <Formula id="VascularEndoVolume.VOLUME_VascularEndo_rect" name="VOLUME_VascularEndo_rect" dim="Volume" formula="SA_pls_int*d_endo/1000">
-            <Paths>
-              <Path path="107" as="108" dim="15" />
-              <Path path="543" as="110" dim="111" />
-            </Paths>
-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_rect" name="PARAM_K_Water_INT_rect" dim="Dimensionless" formula="K_water_int">
-            <Paths>
-              <Path path="544" as="120" />
-            </Paths>
-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_rect" name="PARAM_K_Water_CELL_rect" dim="Dimensionless" formula="K_water_cell">
-            <Paths>
-              <Path path="545" as="124" />
-            </Paths>
-          </Formula>
-          <Formula id="VascularEndoVolume.VOLUME_VascularEndo_liv" name="VOLUME_VascularEndo_liv" dim="Volume" formula="SA_pls_int*d_endo/1000">
-            <Paths>
-              <Path path="107" as="108" dim="15" />
-              <Path path="546" as="110" dim="111" />
-            </Paths>
-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_liv" name="PARAM_K_Water_INT_liv" dim="Dimensionless" formula="K_water_int">
-            <Paths>
-              <Path path="547" as="120" />
-            </Paths>
-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_liv" name="PARAM_K_Water_CELL_liv" dim="Dimensionless" formula="K_water_cell">
-            <Paths>
-              <Path path="548" as="124" />
-            </Paths>
-          </Formula>
-          <Formula id="VascularEndoVolume.VOLUME_VascularEndo_lng" name="VOLUME_VascularEndo_lng" dim="Volume" formula="SA_pls_int*d_endo/1000">
-            <Paths>
-              <Path path="107" as="108" dim="15" />
-              <Path path="549" as="110" dim="111" />
-            </Paths>
-          </Formula>
-          <Formula id="Individual_PKSim.PARAM_Q_lng" name="PARAM_Q_lng" dim="Dimensionless" formula="Q_sto + Q_sin + Q_lin + Q_pan + Q_spl + Q_liv + Q_mus + Q_fat + Q_skn + Q_kid + Q_brn + Q_hrt + Q_bon + Q_tes">
-            <Paths>
-              <Path path="550" as="551" dim="145" />
-              <Path path="552" as="553" dim="145" />
-              <Path path="554" as="555" dim="145" />
-              <Path path="556" as="557" dim="145" />
-              <Path path="558" as="559" dim="145" />
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-              <Path path="576" as="577" dim="145" />
-            </Paths>
-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_lng" name="PARAM_K_Water_INT_lng" dim="Dimensionless" formula="K_water_int">
-            <Paths>
-              <Path path="578" as="120" />
-            </Paths>
-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_lng" name="PARAM_K_Water_CELL_lng" dim="Dimensionless" formula="K_water_cell">
-            <Paths>
-              <Path path="579" as="124" />
-            </Paths>
-          </Formula>
-          <Formula id="VascularEndoVolume.VOLUME_VascularEndo_mus" name="VOLUME_VascularEndo_mus" dim="Volume" formula="SA_pls_int*d_endo/1000">
-            <Paths>
-              <Path path="107" as="108" dim="15" />
-              <Path path="580" as="110" dim="111" />
-            </Paths>
-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_mus" name="PARAM_K_Water_INT_mus" dim="Dimensionless" formula="K_water_int">
-            <Paths>
-              <Path path="581" as="120" />
-            </Paths>
-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_mus" name="PARAM_K_Water_CELL_mus" dim="Dimensionless" formula="K_water_cell">
-            <Paths>
-              <Path path="582" as="124" />
-            </Paths>
-          </Formula>
-          <Formula id="VascularEndoVolume.VOLUME_VascularEndo_pan" name="VOLUME_VascularEndo_pan" dim="Volume" formula="SA_pls_int*d_endo/1000">
-            <Paths>
-              <Path path="107" as="108" dim="15" />
-              <Path path="583" as="110" dim="111" />
-            </Paths>
-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_pan" name="PARAM_K_Water_INT_pan" dim="Dimensionless" formula="K_water_int">
-            <Paths>
-              <Path path="584" as="120" />
-            </Paths>
-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_pan" name="PARAM_K_Water_CELL_pan" dim="Dimensionless" formula="K_water_cell">
-            <Paths>
-              <Path path="585" as="124" />
-            </Paths>
-          </Formula>
-          <Formula id="Individual_PKSim.PARAM_Q_Lymph_pve" name="PARAM_Q_Lymph_pve" dim="Dimensionless" formula="Q_Lymph_sto + Q_Lymph_sin_incl_Mucosa + Q_Lymph_lin_incl_Mucosa + Q_Lymph_pan + Q_Lymph_spl">
-            <Paths>
-              <Path path="586" as="587" dim="145" />
-              <Path path="588" as="589" dim="145" />
-              <Path path="590" as="591" dim="145" />
-              <Path path="592" as="593" dim="145" />
-              <Path path="594" as="595" dim="145" />
-            </Paths>
-          </Formula>
-          <Formula id="Individual_PKSim.PARAM_Q_pve" name="PARAM_Q_pve" dim="Dimensionless" formula="Q_sto + Q_sin + Q_lin + Q_pan + Q_spl">
-            <Paths>
-              <Path path="562" as="563" dim="145" />
-              <Path path="568" as="569" dim="145" />
-              <Path path="572" as="573" dim="145" />
-              <Path path="574" as="575" dim="145" />
-              <Path path="576" as="577" dim="145" />
-            </Paths>
-          </Formula>
-          <Formula id="VascularEndoVolume.VOLUME_VascularEndo_skn" name="VOLUME_VascularEndo_skn" dim="Volume" formula="SA_pls_int*d_endo/1000">
-            <Paths>
-              <Path path="107" as="108" dim="15" />
-              <Path path="596" as="110" dim="111" />
-            </Paths>
-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_skn" name="PARAM_K_Water_INT_skn" dim="Dimensionless" formula="K_water_int">
-            <Paths>
-              <Path path="597" as="120" />
-            </Paths>
-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_skn" name="PARAM_K_Water_CELL_skn" dim="Dimensionless" formula="K_water_cell">
-            <Paths>
-              <Path path="598" as="124" />
-            </Paths>
-          </Formula>
-          <Formula id="VascularEndoVolume.VOLUME_VascularEndo_spl" name="VOLUME_VascularEndo_spl" dim="Volume" formula="SA_pls_int*d_endo/1000">
-            <Paths>
-              <Path path="107" as="108" dim="15" />
-              <Path path="599" as="110" dim="111" />
-            </Paths>
-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_Water_INT_spl" name="PARAM_K_Water_INT_spl" dim="Dimensionless" formula="K_water_int">
-            <Paths>
-              <Path path="600" as="120" />
-            </Paths>
-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_Water_CELL_spl" name="PARAM_K_Water_CELL_spl" dim="Dimensionless" formula="K_water_cell">
-            <Paths>
-              <Path path="601" as="124" />
-            </Paths>
-          </Formula>
-          <Formula id="Individual_PKSim.VOLUME_Saliva_Organ" name="VOLUME_Saliva_Organ" dim="Volume" formula="0.006 * BW / 73">
-            <Paths>
-              <Path path="16" as="17" dim="18" />
-            </Paths>
-          </Formula>
-          <Formula id="CompartmentsVolume_4Comp.VOLUME_slv_slv" name="VOLUME_slv_slv" dim="Volume" formula="V_slv">
-            <Paths>
-              <Path path="602" as="603" dim="21" />
-            </Paths>
-          </Formula>
-          <Formula id="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls_Blood_Organ" name="PARAM_SA_rbc_pls_Blood_Organ" dim="Surface" formula="HCT * A_to_V_bc * 0.6 * V * 1000">
-            <Paths>
-              <Path path="604" as="97" dim="21" />
-              <Path path="7" as="8" />
-              <Path path="605" as="606" />
-            </Paths>
-          </Formula>
-          <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_bon" name="PARAM_SA_int_cell_bon" dim="Surface" formula="(V_bon * 1000 / 28.2)^0.75 * 10 * 1E4">
-            <Paths>
-              <Path path="604" as="23" dim="21" />
-            </Paths>
-          </Formula>
-          <Formula id="DiffusionCommon_PKSim.PARAM_P_int_cell" name="PARAM_P_int_cell" dim="Velocity" formula="P * P_int_cell_factor">
-            <Paths>
-              <Path path="607" as="608" />
-              <Path path="2" as="3" dim="4" />
-            </Paths>
-          </Formula>
-          <Formula id="DiffusionCommon_PKSim.PARAM_P_cell_int" name="PARAM_P_cell_int" dim="Velocity" formula="P * P_cell_int_factor">
-            <Paths>
-              <Path path="609" as="610" />
-              <Path path="2" as="3" dim="4" />
-            </Paths>
-          </Formula>
-          <Formula id="DiffusionCommon_PKSim.PARAM_PA_int_cell" name="PARAM_PA_int_cell" dim="Dimensionless" formula="P_int_cell * SA /1000">
-            <Paths>
-              <Path path="611" as="612" dim="4" />
-              <Path path="613" as="614" dim="111" />
-            </Paths>
-          </Formula>
-          <Formula id="DiffusionCommon_PKSim.PARAM_PA_cell_int" name="PARAM_PA_cell_int" dim="Dimensionless" formula="P_cell_int * SA /1000">
-            <Paths>
-              <Path path="615" as="616" dim="4" />
-              <Path path="613" as="614" dim="111" />
-            </Paths>
-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_wat_cell" name="PARAM_K_wat_cell" dim="Dimensionless" formula="fu/K_cell_pls">
-            <Paths>
-              <Path path="617" as="618" />
-              <Path path="98" as="99" dim="100" />
-            </Paths>
-          </Formula>
-          <Formula id="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int" name="PARAM_SA_pls_int" dim="Surface" formula="k * f_vas_org * V_org">
-            <Paths>
-              <Path path="619" as="620" />
-              <Path path="604" as="115" dim="21" />
-              <Path path="621" as="266" />
-            </Paths>
-          </Formula>
-          <BlackBoxFormula id="BlackBox_CalculationMethod.INTERSTITIAL PARTITION COEFFICIENT FORMULA" name="INTERSTITIAL PARTITION COEFFICIENT FORMULA" dim="Dimensionless" />
-          <Formula id="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls" name="PARAM_SA_rbc_pls" dim="Surface" formula="HCT * A_to_V_bc * 0.6 * V * f_vas * 1000">
-            <Paths>
-              <Path path="619" as="95" />
-              <Path path="604" as="97" dim="21" />
-              <Path path="7" as="8" />
-              <Path path="605" as="606" />
-            </Paths>
-          </Formula>
-          <Formula id="DiffusionPlasma_PKSim.PARAM_P_endothelial_Brain" name="PARAM_P_endothelial_Brain" dim="Velocity" formula="P/2">
-            <Paths>
-              <Path path="2" as="3" dim="4" />
-            </Paths>
-          </Formula>
-          <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_brn" name="PARAM_SA_int_cell_brn" dim="Surface" formula="(V_brn  * 1000 / 1.671)^0.75 * 0.0006 * 1E4">
-            <Paths>
-              <Path path="604" as="25" dim="21" />
-            </Paths>
-          </Formula>
-          <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_fat" name="PARAM_SA_int_cell_fat" dim="Surface" formula="(V_fat * 1000 / 14.2)^0.75 * 5 * 1E4">
-            <Paths>
-              <Path path="604" as="27" dim="21" />
-            </Paths>
-          </Formula>
-          <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_tes" name="PARAM_SA_int_cell_tes" dim="Surface" formula="(V_tes * 1000 / 2.5)^0.75 * 2 * 1E4">
-            <Paths>
-              <Path path="604" as="29" dim="21" />
-            </Paths>
-          </Formula>
-          <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_hrt" name="PARAM_SA_int_cell_hrt" dim="Surface" formula="(V_hrt * 1000 / 1.2)^0.75 * 7.54 * 1E4">
-            <Paths>
-              <Path path="604" as="31" dim="21" />
-            </Paths>
-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_water_cell_Kidney" name="PARAM_K_water_cell_Kidney" dim="Dimensionless" formula="K_water_cell">
-            <Paths>
-              <Path path="153" as="124" />
-            </Paths>
-          </Formula>
-          <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_kid" name="PARAM_SA_int_cell_kid" dim="Surface" formula="(V_kid * 1000 / 7)^0.75 * 1000 * 1E4">
-            <Paths>
-              <Path path="604" as="33" dim="21" />
-            </Paths>
-          </Formula>
-          <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K7" name="PARAM_pKa_pH_WS_lum_K7" dim="Dimensionless" formula="F1*(1-F2)*(1-F3)">
-            <Paths>
-              <Path path="205" as="206" />
-              <Path path="207" as="208" />
-              <Path path="209" as="210" />
-            </Paths>
-          </Formula>
-          <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K8" name="PARAM_pKa_pH_WS_lum_K8" dim="Dimensionless" formula="(1-F1)*(1-F2)*(1-F3)">
-            <Paths>
-              <Path path="205" as="206" />
-              <Path path="207" as="208" />
-              <Path path="209" as="210" />
-            </Paths>
-          </Formula>
-          <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K4" name="PARAM_pKa_pH_WS_lum_K4" dim="Dimensionless" formula="F1*F2*(1-F3)">
-            <Paths>
-              <Path path="205" as="206" />
-              <Path path="207" as="208" />
-              <Path path="209" as="210" />
-            </Paths>
-          </Formula>
-          <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K4" name="PARAM_pKa_pH_WS_mucosacell_K4" dim="Dimensionless" formula="F1*F2*(1-F3)">
-            <Paths>
-              <Path path="622" as="206" />
-              <Path path="623" as="208" />
-              <Path path="624" as="210" />
-            </Paths>
-          </Formula>
-          <Formula id="Lumen_PKSim.PARAM_DrugAbsorption_trans" name="PARAM_DrugAbsorption_trans" dim="Rate" formula="OralApplicationsEnabled ? P_int_trans*Ageom*AeffFactor*(P_int_trans_lum_cell_factor*min(Solubility/ MW ;DrugLiquid/(Liquid))-(k_Liquid_trans ? P_int_trans_cell_lum_factor*fu/K_cell_pls*DrugMucosa : 0))*1e-3 : 0">
-            <Paths>
-              <Path path="617" as="618" />
-              <Path path="625" as="626" />
-              <Path path="627" as="628" dim="111" />
-              <Path path="629" as="159" dim="21" />
-              <Path path="630" as="631" dim="632" />
-              <Path path="633" as="634" dim="635" />
-              <Path path="98" as="99" dim="100" />
-              <Path path="636" as="637" dim="4" />
-              <Path path="638" as="639" dim="640" />
-              <Path path="641" as="642" />
-              <Path path="643" as="644" />
-              <Path path="645" as="232" dim="233" />
-              <Path path="646" as="180" />
-              <Path path="647" as="648" />
-            </Paths>
-          </Formula>
-          <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_cell_lum_factor" name="PARAM_P_int_trans_cell_lum_factor" dim="Dimensionless" formula="UsePenaltyFactor ? K1+ (K2 +K3 +K4)* base ^ 1 + K5* base ^ max(CT0+CT1;-CT0-CT1) +K6* base ^ max(CT0+CT2;-CT0-CT2) +K7* base ^ max(CT2+CT1;-CT2-CT1) +K8* base ^ max(CT0+CT1+CT2;-CT0-CT1-CT2) : 1">
-            <Paths>
-              <Path path="649" as="212" />
-              <Path path="650" as="214" />
-              <Path path="651" as="216" />
-              <Path path="652" as="218" />
-              <Path path="653" as="220" />
-              <Path path="654" as="222" />
-              <Path path="655" as="224" />
-              <Path path="656" as="226" />
-              <Path path="657" as="228" />
-              <Path path="201" as="202" />
-              <Path path="197" as="198" />
-              <Path path="189" as="190" />
-              <Path path="658" as="659" />
-            </Paths>
-          </Formula>
-          <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_P_int_trans_lum_cell_factor" name="PARAM_P_int_trans_lum_cell_factor" dim="Dimensionless" formula="UsePenaltyFactor ? K1+ (K2 +K3 +K4)* base ^ 1 + K5* base ^ max(CT0+CT1;-CT0-CT1) +K6* base ^ max(CT0+CT2;-CT0-CT2) +K7* base ^ max(CT2+CT1;-CT2-CT1) +K8* base ^ max(CT0+CT1+CT2;-CT0-CT1-CT2) : 1">
-            <Paths>
-              <Path path="211" as="212" />
-              <Path path="213" as="214" />
-              <Path path="215" as="216" />
-              <Path path="217" as="218" />
-              <Path path="219" as="220" />
-              <Path path="221" as="222" />
-              <Path path="223" as="224" />
-              <Path path="225" as="226" />
-              <Path path="657" as="228" />
-              <Path path="201" as="202" />
-              <Path path="197" as="198" />
-              <Path path="189" as="190" />
-              <Path path="658" as="659" />
-            </Paths>
-          </Formula>
-          <Formula id="Lumen_PKSim.PARAM_K_cell_pls_UpperJejunum" name="PARAM_K_cell_pls_UpperJejunum" dim="Dimensionless" formula="K_cell_pls">
-            <Paths>
-              <Path path="660" as="618" />
-            </Paths>
-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_UpperJejunum" name="PARAM_K_wat_cell_Lumen_UpperJejunum" dim="Dimensionless" formula="K_water_cell">
-            <Paths>
-              <Path path="461" as="124" />
-            </Paths>
-          </Formula>
-          <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F1" name="PARAM_pKa_pH_WS_mucosacell_F1" dim="Dimensionless" formula="CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1">
-            <Paths>
-              <Path path="201" as="202" />
-              <Path path="191" as="192" />
-              <Path path="203" as="204" />
-              <Path path="661" as="196" />
-            </Paths>
-          </Formula>
-          <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F2" name="PARAM_pKa_pH_WS_mucosacell_F2" dim="Dimensionless" formula="CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1">
-            <Paths>
-              <Path path="197" as="198" />
-              <Path path="191" as="192" />
-              <Path path="199" as="200" />
-              <Path path="661" as="196" />
-            </Paths>
-          </Formula>
-          <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F3" name="PARAM_pKa_pH_WS_mucosacell_F3" dim="Dimensionless" formula="CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1">
-            <Paths>
-              <Path path="189" as="190" />
-              <Path path="191" as="192" />
-              <Path path="193" as="194" />
-              <Path path="661" as="196" />
-            </Paths>
-          </Formula>
-          <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K1" name="PARAM_pKa_pH_WS_mucosacell_K1" dim="Dimensionless" formula="F1*F2*F3">
-            <Paths>
-              <Path path="622" as="206" />
-              <Path path="623" as="208" />
-              <Path path="624" as="210" />
-            </Paths>
-          </Formula>
-          <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K6" name="PARAM_pKa_pH_WS_lum_K6" dim="Dimensionless" formula="(1-F1)*F2*(1-F3)">
-            <Paths>
-              <Path path="205" as="206" />
-              <Path path="207" as="208" />
-              <Path path="209" as="210" />
-            </Paths>
-          </Formula>
-          <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K3" name="PARAM_pKa_pH_WS_mucosacell_K3" dim="Dimensionless" formula="F1*(1-F2)*F3">
-            <Paths>
-              <Path path="622" as="206" />
-              <Path path="623" as="208" />
-              <Path path="624" as="210" />
-            </Paths>
-          </Formula>
-          <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K5" name="PARAM_pKa_pH_WS_lum_K5" dim="Dimensionless" formula="(1-F1)*(1-F2)*F3">
-            <Paths>
-              <Path path="205" as="206" />
-              <Path path="207" as="208" />
-              <Path path="209" as="210" />
-            </Paths>
-          </Formula>
-          <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K5" name="PARAM_pKa_pH_WS_mucosacell_K5" dim="Dimensionless" formula="(1-F1)*(1-F2)*F3">
-            <Paths>
-              <Path path="622" as="206" />
-              <Path path="623" as="208" />
-              <Path path="624" as="210" />
-            </Paths>
-          </Formula>
-          <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K6" name="PARAM_pKa_pH_WS_mucosacell_K6" dim="Dimensionless" formula="(1-F1)*F2*(1-F3)">
-            <Paths>
-              <Path path="622" as="206" />
-              <Path path="623" as="208" />
-              <Path path="624" as="210" />
-            </Paths>
-          </Formula>
-          <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K7" name="PARAM_pKa_pH_WS_mucosacell_K7" dim="Dimensionless" formula="F1*(1-F2)*(1-F3)">
-            <Paths>
-              <Path path="622" as="206" />
-              <Path path="623" as="208" />
-              <Path path="624" as="210" />
-            </Paths>
-          </Formula>
-          <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K8" name="PARAM_pKa_pH_WS_mucosacell_K8" dim="Dimensionless" formula="(1-F1)*(1-F2)*(1-F3)">
-            <Paths>
-              <Path path="622" as="206" />
-              <Path path="623" as="208" />
-              <Path path="624" as="210" />
-            </Paths>
-          </Formula>
-          <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F1" name="PARAM_pKa_pH_WS_lum_F1" dim="Dimensionless" formula="CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1">
-            <Paths>
-              <Path path="662" as="196" />
-              <Path path="201" as="202" />
-              <Path path="191" as="192" />
-              <Path path="203" as="204" />
-            </Paths>
-          </Formula>
-          <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F2" name="PARAM_pKa_pH_WS_lum_F2" dim="Dimensionless" formula="CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1">
-            <Paths>
-              <Path path="662" as="196" />
-              <Path path="197" as="198" />
-              <Path path="191" as="192" />
-              <Path path="199" as="200" />
-            </Paths>
-          </Formula>
-          <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_F3" name="PARAM_pKa_pH_WS_lum_F3" dim="Dimensionless" formula="CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1">
-            <Paths>
-              <Path path="662" as="196" />
-              <Path path="189" as="190" />
-              <Path path="191" as="192" />
-              <Path path="193" as="194" />
-            </Paths>
-          </Formula>
-          <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K1" name="PARAM_pKa_pH_WS_lum_K1" dim="Dimensionless" formula="F1*F2*F3">
-            <Paths>
-              <Path path="205" as="206" />
-              <Path path="207" as="208" />
-              <Path path="209" as="210" />
-            </Paths>
-          </Formula>
-          <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K2" name="PARAM_pKa_pH_WS_lum_K2" dim="Dimensionless" formula="(1-F1)*F2*F3">
-            <Paths>
-              <Path path="205" as="206" />
-              <Path path="207" as="208" />
-              <Path path="209" as="210" />
-            </Paths>
-          </Formula>
-          <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_lum_K3" name="PARAM_pKa_pH_WS_lum_K3" dim="Dimensionless" formula="F1*(1-F2)*F3">
-            <Paths>
-              <Path path="205" as="206" />
-              <Path path="207" as="208" />
-              <Path path="209" as="210" />
-            </Paths>
-          </Formula>
-          <Formula id="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_K2" name="PARAM_pKa_pH_WS_mucosacell_K2" dim="Dimensionless" formula="(1-F1)*F2*F3">
-            <Paths>
-              <Path path="622" as="206" />
-              <Path path="623" as="208" />
-              <Path path="624" as="210" />
-            </Paths>
-          </Formula>
-          <Formula id="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPveBloodCells" name="PARAM_MassTransferMucosaToPveBloodCells" dim="Rate" formula="Q*HCT*C_bc">
-            <Paths>
-              <Path path="663" as="664" dim="635" />
-              <Path path="665" as="451" dim="145" />
-              <Path path="7" as="8" />
-            </Paths>
-          </Formula>
-          <Formula id="MassTransferLink_PKSim.PARAM_MassTransferMucosaToPvePlasma" name="PARAM_MassTransferMucosaToPvePlasma" dim="Rate" formula="Q*(1-HCT)*C_pls">
-            <Paths>
-              <Path path="663" as="666" dim="635" />
-              <Path path="665" as="451" dim="145" />
-              <Path path="7" as="8" />
-            </Paths>
-          </Formula>
-          <Formula id="Lumen_PKSim.PARAM_DrugAbsorption_para" name="PARAM_DrugAbsorption_para" dim="Rate" formula="OralApplicationsEnabled ? P_int_para*Ageom*AeffFactor*(min(Solubility/ MW ;DrugLiquid/(Liquid))-(k_Liquid_para ? fu*DrugMucosa : 0))*1e-3 : 0">
-            <Paths>
-              <Path path="625" as="626" />
-              <Path path="627" as="628" dim="111" />
-              <Path path="629" as="159" dim="21" />
-              <Path path="630" as="631" dim="632" />
-              <Path path="633" as="634" dim="635" />
-              <Path path="98" as="99" dim="100" />
-              <Path path="667" as="668" dim="4" />
-              <Path path="638" as="639" dim="640" />
-              <Path path="645" as="232" dim="233" />
-              <Path path="646" as="180" />
-              <Path path="669" as="670" />
-            </Paths>
-          </Formula>
-          <Formula id="Lumen_PKSim.PARAM_K_cell_pls_LowerJejunum" name="PARAM_K_cell_pls_LowerJejunum" dim="Dimensionless" formula="K_cell_pls">
-            <Paths>
-              <Path path="671" as="618" />
-            </Paths>
-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_LowerJejunum" name="PARAM_K_wat_cell_Lumen_LowerJejunum" dim="Dimensionless" formula="K_water_cell">
-            <Paths>
-              <Path path="465" as="124" />
-            </Paths>
-          </Formula>
-          <Formula id="Lumen_PKSim.PARAM_OralMassAbsorbed_RHS" name="PARAM_OralMassAbsorbed_RHS" dim="Rate" formula="DA_para_duo+DA_trans_duo+DA_para_uje+DA_trans_uje+DA_para_lje+DA_trans_lje+DA_para_uil+DA_trans_uil+DA_para_lil+DA_trans_lil+DA_para_cae+DA_trans_cae+DA_para_colasc+DA_trans_colasc+DA_para_coltrans+DA_trans_coltrans+DA_para_coldesc+DA_trans_coldesc+DA_para_colsigm+DA_trans_colsigm+DA_para_rect+DA_trans_rect">
-            <Paths>
-              <Path path="326" as="327" dim="176" />
-              <Path path="336" as="337" dim="176" />
-              <Path path="356" as="357" dim="176" />
-              <Path path="366" as="367" dim="176" />
-              <Path path="346" as="347" dim="176" />
-              <Path path="274" as="275" dim="176" />
-              <Path path="314" as="315" dim="176" />
-              <Path path="294" as="295" dim="176" />
-              <Path path="375" as="376" dim="176" />
-              <Path path="304" as="305" dim="176" />
-              <Path path="284" as="285" dim="176" />
-              <Path path="328" as="329" dim="176" />
-              <Path path="338" as="339" dim="176" />
-              <Path path="358" as="359" dim="176" />
-              <Path path="368" as="369" dim="176" />
-              <Path path="348" as="349" dim="176" />
-              <Path path="276" as="277" dim="176" />
-              <Path path="316" as="317" dim="176" />
-              <Path path="296" as="297" dim="176" />
-              <Path path="377" as="378" dim="176" />
-              <Path path="306" as="307" dim="176" />
-              <Path path="286" as="287" dim="176" />
-            </Paths>
-          </Formula>
-          <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_sto" name="PARAM_SA_int_cell_sto" dim="Surface" formula="(V_sto * 1000 / 1.1)^0.75 * 1000 * 1E4">
-            <Paths>
-              <Path path="604" as="53" dim="21" />
-            </Paths>
-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_UpperIleum" name="PARAM_K_wat_cell_Lumen_UpperIleum" dim="Dimensionless" formula="K_water_cell">
-            <Paths>
-              <Path path="469" as="124" />
-            </Paths>
-          </Formula>
-          <Formula id="Lumen_PKSim.PARAM_K_cell_pls_UpperIleum" name="PARAM_K_cell_pls_UpperIleum" dim="Dimensionless" formula="K_cell_pls">
-            <Paths>
-              <Path path="672" as="618" />
-            </Paths>
-          </Formula>
-          <Formula id="SurfaceAreaRbcPls_PKSim.PARAM_SA_rbc_pls_sinlin" name="PARAM_SA_rbc_pls_sinlin" dim="Surface" formula="HCT * A_to_V_bc * 0.6 * (V-V_Mucosa) * f_vas * 1000">
-            <Paths>
-              <Path path="619" as="95" />
-              <Path path="604" as="97" dim="21" />
-              <Path path="673" as="435" dim="21" />
-              <Path path="7" as="8" />
-              <Path path="605" as="606" />
-            </Paths>
-          </Formula>
-          <Formula id="SurfaceAreaPlsInt_VAR1.PARAM_SA_pls_int_sinlin" name="PARAM_SA_pls_int_sinlin" dim="Surface" formula="k * f_vas_org * (V_org-V_Mucosa)">
-            <Paths>
-              <Path path="619" as="620" />
-              <Path path="604" as="115" dim="21" />
-              <Path path="673" as="435" dim="21" />
-              <Path path="621" as="266" />
-            </Paths>
-          </Formula>
-          <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_sin" name="PARAM_SA_int_cell_sin" dim="Surface" formula="((V_sin-V_Mucosa) * 1000 / 11.1)^0.75 * 1000 * 1E4">
-            <Paths>
-              <Path path="604" as="49" dim="21" />
-              <Path path="674" as="435" dim="21" />
-            </Paths>
-          </Formula>
-          <Formula id="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaBloodCells" name="PARAM_MassTransferIntestineToMucosaBloodCells" dim="Rate" formula="Q*HCT*C_bc">
-            <Paths>
-              <Path path="675" as="451" dim="145" />
-              <Path path="663" as="664" dim="635" />
-              <Path path="7" as="8" />
-            </Paths>
-          </Formula>
-          <Formula id="MassTransferLink_PKSim.PARAM_MassTransferIntestineToMucosaPlasma" name="PARAM_MassTransferIntestineToMucosaPlasma" dim="Rate" formula="Q*(1-HCT)*C_pls">
-            <Paths>
-              <Path path="675" as="451" dim="145" />
-              <Path path="663" as="666" dim="635" />
-              <Path path="7" as="8" />
-            </Paths>
-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_LowerIleum" name="PARAM_K_wat_cell_Lumen_LowerIleum" dim="Dimensionless" formula="K_water_cell">
-            <Paths>
-              <Path path="473" as="124" />
-            </Paths>
-          </Formula>
-          <Formula id="Lumen_PKSim.PARAM_K_cell_pls_LowerIleum" name="PARAM_K_cell_pls_LowerIleum" dim="Dimensionless" formula="K_cell_pls">
-            <Paths>
-              <Path path="676" as="618" />
-            </Paths>
-          </Formula>
-          <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_lin" name="PARAM_SA_int_cell_lin" dim="Surface" formula="((V_lin-V_Mucosa) * 1000 / 11.1)^0.75 * 1000 * 1E4">
-            <Paths>
-              <Path path="604" as="35" dim="21" />
-              <Path path="677" as="435" dim="21" />
-            </Paths>
-          </Formula>
-          <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_liv" name="PARAM_SA_int_cell_liv" dim="Surface" formula="(V_liv * 1000 / 10)^0.75 * 82 * 1E4">
-            <Paths>
-              <Path path="604" as="37" dim="21" />
-            </Paths>
-          </Formula>
-          <Formula id="PlasmaClearance_PKSim.PARAM_min_PA_Q" name="PARAM_min_PA_Q" dim="Dimensionless" formula="Min(PA_liv ;Q_liv + Q_pve)">
-            <Paths>
-              <Path path="678" as="679" dim="145" />
-              <Path path="665" as="565" dim="145" />
-              <Path path="680" as="681" dim="145" />
-            </Paths>
-          </Formula>
-          <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_lng" name="PARAM_SA_int_cell_lng" dim="Surface" formula="(V_lng * 1000  / 2.2)^0.75 * 0.096 * 1E4">
-            <Paths>
-              <Path path="604" as="39" dim="21" />
-            </Paths>
-          </Formula>
-          <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mus" name="PARAM_SA_int_cell_mus" dim="Surface" formula="(V_mus * 1000 / 110.1)^0.75 * 7.54 * 1E4">
-            <Paths>
-              <Path path="604" as="41" dim="21" />
-            </Paths>
-          </Formula>
-          <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_pan" name="PARAM_SA_int_cell_pan" dim="Surface" formula="(V_pan * 1000 / 1.3)^0.75 * 1000 * 1E4">
-            <Paths>
-              <Path path="604" as="43" dim="21" />
-            </Paths>
-          </Formula>
-          <Formula id="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_Rectum" name="PARAM_K_wat_cell_Lumen_Rectum" dim="Dimensionless" formula="K_water_cell">
-            <Paths>
-              <Path path="545" as="124" />
-            </Paths>
-          </Formula>
-          <Formula id="Lumen_PKSim.PARAM_K_cell_pls_Rectum" name="PARAM_K_cell_pls_Rectum" dim="Dimensionless" formula="K_cell_pls">
-            <Paths>
-              <Path path="682" as="618" />
-            </Paths>
-          </Formula>
-          <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_skn" name="PARAM_SA_int_cell_skn" dim="Surface" formula="(V_skn * 1000 / 43.4)^0.75 * 0.12 * 1E4">
-            <Paths>
-              <Path path="604" as="47" dim="21" />
-            </Paths>
-          </Formula>
-          <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_spl" name="PARAM_SA_int_cell_spl" dim="Surface" formula="(V_spl * 1000 / 1.3)^0.75 * 1000 * 1E4">
-            <Paths>
-              <Path path="604" as="51" dim="21" />
-            </Paths>
-          </Formula>
-          <Formula id="DistributionSaliva_PKSim.PARAM_K_cell_pls_slv" name="PARAM_K_cell_pls_slv" dim="Dimensionless" formula="R * fu">
-            <Paths>
-              <Path path="683" as="684" />
-              <Path path="98" as="99" dim="100" />
-            </Paths>
-          </Formula>
-          <Formula id="DistributionSaliva_PKSim.PARAM_SalivaPlasmaRatio" name="PARAM_SalivaPlasmaRatio" dim="Dimensionless" formula="1">
-            <Paths>
-              <Path path="203" as="204" />
-              <Path path="199" as="200" />
-              <Path path="193" as="194" />
-              <Path path="685" as="686" />
-              <Path path="687" as="688" />
-            </Paths>
-          </Formula>
-          <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mucosa_duo" name="PARAM_SA_int_cell_mucosa_duo" dim="Dimensionless" formula="Ageom * AeffFactor / MicrovilliFactor">
-            <Paths>
-              <Path path="689" as="626" />
-              <Path path="690" as="628" dim="111" />
-              <Path path="691" as="692" />
-            </Paths>
-          </Formula>
-          <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mucosa_uje" name="PARAM_SA_int_cell_mucosa_uje" dim="Dimensionless" formula="Ageom * AeffFactor / MicrovilliFactor">
-            <Paths>
-              <Path path="693" as="626" />
-              <Path path="694" as="628" dim="111" />
-              <Path path="695" as="692" />
-            </Paths>
-          </Formula>
-          <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mucosa_lje" name="PARAM_SA_int_cell_mucosa_lje" dim="Dimensionless" formula="Ageom * AeffFactor / MicrovilliFactor">
-            <Paths>
-              <Path path="696" as="626" />
-              <Path path="697" as="628" dim="111" />
-              <Path path="698" as="692" />
-            </Paths>
-          </Formula>
-          <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mucosa_uil" name="PARAM_SA_int_cell_mucosa_uil" dim="Dimensionless" formula="Ageom * AeffFactor / MicrovilliFactor">
-            <Paths>
-              <Path path="699" as="626" />
-              <Path path="700" as="628" dim="111" />
-              <Path path="701" as="692" />
-            </Paths>
-          </Formula>
-          <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mucosa_lil" name="PARAM_SA_int_cell_mucosa_lil" dim="Dimensionless" formula="Ageom * AeffFactor / MicrovilliFactor">
-            <Paths>
-              <Path path="702" as="626" />
-              <Path path="703" as="628" dim="111" />
-              <Path path="704" as="692" />
-            </Paths>
-          </Formula>
-          <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mucosa_cae" name="PARAM_SA_int_cell_mucosa_cae" dim="Dimensionless" formula="Ageom * AeffFactor / MicrovilliFactor">
-            <Paths>
-              <Path path="705" as="626" />
-              <Path path="706" as="628" dim="111" />
-              <Path path="707" as="692" />
-            </Paths>
-          </Formula>
-          <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mucosa_colasc" name="PARAM_SA_int_cell_mucosa_colasc" dim="Dimensionless" formula="Ageom * AeffFactor / MicrovilliFactor">
-            <Paths>
-              <Path path="708" as="626" />
-              <Path path="709" as="628" dim="111" />
-              <Path path="710" as="692" />
-            </Paths>
-          </Formula>
-          <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mucosa_coltrans" name="PARAM_SA_int_cell_mucosa_coltrans" dim="Dimensionless" formula="Ageom * AeffFactor / MicrovilliFactor">
-            <Paths>
-              <Path path="711" as="626" />
-              <Path path="712" as="628" dim="111" />
-              <Path path="713" as="692" />
-            </Paths>
-          </Formula>
-          <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mucosa_coldesc" name="PARAM_SA_int_cell_mucosa_coldesc" dim="Dimensionless" formula="Ageom * AeffFactor / MicrovilliFactor">
-            <Paths>
-              <Path path="714" as="626" />
-              <Path path="715" as="628" dim="111" />
-              <Path path="716" as="692" />
-            </Paths>
-          </Formula>
-          <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mucosa_colsigm" name="PARAM_SA_int_cell_mucosa_colsigm" dim="Dimensionless" formula="Ageom * AeffFactor / MicrovilliFactor">
-            <Paths>
-              <Path path="717" as="626" />
-              <Path path="718" as="628" dim="111" />
-              <Path path="719" as="692" />
-            </Paths>
-          </Formula>
-          <Formula id="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_mucosa_rect" name="PARAM_SA_int_cell_mucosa_rect" dim="Dimensionless" formula="Ageom * AeffFactor / MicrovilliFactor">
-            <Paths>
-              <Path path="720" as="626" />
-              <Path path="721" as="628" dim="111" />
-              <Path path="722" as="692" />
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-        <StringMap>
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-          <Map s="MOLECULE|Permeability" id="2" />
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-          <Map s="Organism|Gonads|Volume" id="28" />
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-          <Map s="Organism|Kidney|Volume" id="32" />
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-          <Map s="Organism|Pancreas|Volume" id="42" />
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-          <Map s="Organism|PortalVein|Volume" id="44" />
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-          <Map s="Organism|SmallIntestine|Volume" id="48" />
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-          <Map s="Organism|Spleen|Volume" id="50" />
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-          <Map s="Organism|Stomach|Volume" id="52" />
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-          <Map s="Organism|Brain|Fraction vascular" id="58" />
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-          <Map s="Organism|Lung|Fraction vascular" id="72" />
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-          <Map s="Organism|Muscle|Fraction vascular" id="74" />
-          <Map s="f_vas_mus" id="75" />
-          <Map s="Organism|Pancreas|Fraction vascular" id="76" />
-          <Map s="f_vas_pan" id="77" />
-          <Map s="Organism|Skin|Fraction vascular" id="78" />
-          <Map s="f_vas_skn" id="79" />
-          <Map s="Organism|SmallIntestine|Fraction vascular" id="80" />
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-          <Map s="f_vas_spl" id="83" />
-          <Map s="Organism|Stomach|Fraction vascular" id="84" />
-          <Map s="f_vas_sto" id="85" />
-          <Map s="..|Age" id="86" />
-          <Map s="Age" id="87" />
-          <Map s="Organism|Rate constant for endosomal uptake (global)" id="88" />
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-          <Map s="InversedTime" id="90" />
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-          <Map s="K_rec" id="92" />
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-          <Map s="..|..|Fraction vascular" id="94" />
-          <Map s="f_vas" id="95" />
-          <Map s="..|..|Volume" id="96" />
-          <Map s="V" id="97" />
-          <Map s="MOLECULE|Fraction unbound (plasma)" id="98" />
-          <Map s="fu" id="99" />
-          <Map s="Fraction" id="100" />
-          <Map s="..|Gallbladder ejection half-time" id="101" />
-          <Map s="EHC_HalfTime" id="102" />
-          <Map s="Time" id="103" />
-          <Map s="..|Specific blood flow rate" id="104" />
-          <Map s="Qspec" id="105" />
-          <Map s="Flow (volume) per organ weight" id="106" />
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-          <Map s="d_endo" id="108" />
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-          <Map s="Surface" id="111" />
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-          <Map s="f_int" id="113" />
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-          <Map s="pH_int" id="118" />
-          <Map s="Neighborhoods|Bone_int_Bone_cell|MOLECULE|Partition coefficient (interstitial/water)" id="119" />
-          <Map s="K_water_int" id="120" />
-          <Map s="..|..|Fraction intracellular" id="121" />
-          <Map s="f_cell" id="122" />
-          <Map s="Neighborhoods|Bone_int_Bone_cell|MOLECULE|Partition coefficient (intracellular/water)" id="123" />
-          <Map s="K_water_cell" id="124" />
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-          <Map s="Neighborhoods|Brain_int_Brain_cell|MOLECULE|Partition coefficient (interstitial/water)" id="126" />
-          <Map s="Neighborhoods|Brain_int_Brain_cell|MOLECULE|Partition coefficient (intracellular/water)" id="127" />
-          <Map s="Neighborhoods|Fat_pls_Fat_int|Surface area (plasma/interstitial)" id="128" />
-          <Map s="Neighborhoods|Fat_int_Fat_cell|MOLECULE|Partition coefficient (interstitial/water)" id="129" />
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-          <Map s="Neighborhoods|Gonads_pls_Gonads_int|Surface area (plasma/interstitial)" id="131" />
-          <Map s="Neighborhoods|Gonads_int_Gonads_cell|MOLECULE|Partition coefficient (interstitial/water)" id="132" />
-          <Map s="Neighborhoods|Gonads_int_Gonads_cell|MOLECULE|Partition coefficient (intracellular/water)" id="133" />
-          <Map s="Neighborhoods|Heart_pls_Heart_int|Surface area (plasma/interstitial)" id="134" />
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-          <Map s="Neighborhoods|Kidney_pls_Kidney_int|Surface area (plasma/interstitial)" id="137" />
-          <Map s="Organism|Estimated gestational age" id="138" />
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-          <Map s="Organism|Kidney|GFRmat" id="143" />
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-          <Map s="Hill" id="147" />
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-          <Map s="Neighborhoods|Kidney_int_Kidney_cell|MOLECULE|Partition coefficient (intracellular/water)" id="153" />
-          <Map s="..|Geometric surface area" id="154" />
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-          <Map s="Concentration" id="233" />
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-          <Map s="..|..|..|Height" id="236" />
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-          <Map s="..|..|Stomach|Liquid transfer rate" id="252" />
-          <Map s="..|..|UpperJejunum|FillLevelFlag" id="253" />
-          <Map s="..|r1_p0" id="254" />
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-          <Map s="..|Thickness_p1" id="258" />
-          <Map s="Thickness_p1" id="259" />
-          <Map s="..|Thickness_p2" id="260" />
-          <Map s="Thickness_p2" id="261" />
-          <Map s="..|Thickness_p3" id="262" />
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-          <Map s="..|..|Stomach|Fractional steady state fill level" id="268" />
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-          <Map s="Neighborhoods|Lumen_duo_Duodenum_pls|MOLECULE|Drug absorption rate (lumen to mucosa)" id="274" />
-          <Map s="DA_para_duo" id="275" />
-          <Map s="Neighborhoods|Lumen_duo_Duodenum_cell|MOLECULE|Drug absorption rate (lumen to mucosa)" id="276" />
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-          <Map s="..|..|Duodenum|Intestinal transit rate (absolute)" id="279" />
-          <Map s="..|..|Duodenum|Volume" id="280" />
-          <Map s="..|..|LowerJejunum|FillLevelFlag" id="281" />
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-          <Map s="..|..|Duodenum|Liquid transfer rate" id="283" />
-          <Map s="Neighborhoods|Lumen_uje_UpperJejunum_pls|MOLECULE|Drug absorption rate (lumen to mucosa)" id="284" />
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-          <Map s="Neighborhoods|Lumen_uje_UpperJejunum_cell|MOLECULE|Drug absorption rate (lumen to mucosa)" id="286" />
-          <Map s="DA_trans_uje" id="287" />
-          <Map s="..|..|UpperJejunum|Fractional steady state fill level" id="288" />
-          <Map s="..|..|UpperJejunum|Intestinal transit rate (absolute)" id="289" />
-          <Map s="..|..|UpperJejunum|Volume" id="290" />
-          <Map s="LT_lje" id="291" />
-          <Map s="..|..|UpperJejunum|Liquid transfer rate" id="292" />
-          <Map s="..|..|UpperIleum|FillLevelFlag" id="293" />
-          <Map s="Neighborhoods|Lumen_lje_LowerJejunum_pls|MOLECULE|Drug absorption rate (lumen to mucosa)" id="294" />
-          <Map s="DA_para_lje" id="295" />
-          <Map s="Neighborhoods|Lumen_lje_LowerJejunum_cell|MOLECULE|Drug absorption rate (lumen to mucosa)" id="296" />
-          <Map s="DA_trans_lje" id="297" />
-          <Map s="..|..|LowerJejunum|Fractional steady state fill level" id="298" />
-          <Map s="..|..|LowerJejunum|Intestinal transit rate (absolute)" id="299" />
-          <Map s="..|..|LowerJejunum|Volume" id="300" />
-          <Map s="LT_uil" id="301" />
-          <Map s="..|..|LowerJejunum|Liquid transfer rate" id="302" />
-          <Map s="..|..|LowerIleum|FillLevelFlag" id="303" />
-          <Map s="Neighborhoods|Lumen_uil_UpperIleum_pls|MOLECULE|Drug absorption rate (lumen to mucosa)" id="304" />
-          <Map s="DA_para_uil" id="305" />
-          <Map s="Neighborhoods|Lumen_uil_UpperIleum_cell|MOLECULE|Drug absorption rate (lumen to mucosa)" id="306" />
-          <Map s="DA_trans_uil" id="307" />
-          <Map s="..|..|Caecum|FillLevelFlag" id="308" />
-          <Map s="LT_lil" id="309" />
-          <Map s="..|..|UpperIleum|Liquid transfer rate" id="310" />
-          <Map s="..|..|UpperIleum|Fractional steady state fill level" id="311" />
-          <Map s="..|..|UpperIleum|Intestinal transit rate (absolute)" id="312" />
-          <Map s="..|..|UpperIleum|Volume" id="313" />
-          <Map s="Neighborhoods|Lumen_lil_LowerIleum_pls|MOLECULE|Drug absorption rate (lumen to mucosa)" id="314" />
-          <Map s="DA_para_lil" id="315" />
-          <Map s="Neighborhoods|Lumen_lil_LowerIleum_cell|MOLECULE|Drug absorption rate (lumen to mucosa)" id="316" />
-          <Map s="DA_trans_lil" id="317" />
-          <Map s="..|..|LowerIleum|Fractional steady state fill level" id="318" />
-          <Map s="..|..|LowerIleum|Intestinal transit rate (absolute)" id="319" />
-          <Map s="..|..|LowerIleum|Volume" id="320" />
-          <Map s="Organism|LargeIntestine|Large intestinal transit time factor" id="321" />
-          <Map s="LITT_fact" id="322" />
-          <Map s="LT_cae" id="323" />
-          <Map s="..|..|LowerIleum|Liquid transfer rate" id="324" />
-          <Map s="..|..|ColonAscendens|FillLevelFlag" id="325" />
-          <Map s="Neighborhoods|Lumen_cae_Caecum_pls|MOLECULE|Drug absorption rate (lumen to mucosa)" id="326" />
-          <Map s="DA_para_cae" id="327" />
-          <Map s="Neighborhoods|Lumen_cae_Caecum_cell|MOLECULE|Drug absorption rate (lumen to mucosa)" id="328" />
-          <Map s="DA_trans_cae" id="329" />
-          <Map s="..|..|Caecum|Fractional steady state fill level" id="330" />
-          <Map s="..|..|Caecum|Intestinal transit rate (absolute)" id="331" />
-          <Map s="..|..|Caecum|Volume" id="332" />
-          <Map s="LT_colasc" id="333" />
-          <Map s="..|..|Caecum|Liquid transfer rate" id="334" />
-          <Map s="..|..|ColonTransversum|FillLevelFlag" id="335" />
-          <Map s="Neighborhoods|Lumen_colasc_ColonAscendens_pls|MOLECULE|Drug absorption rate (lumen to mucosa)" id="336" />
-          <Map s="DA_para_colasc" id="337" />
-          <Map s="Neighborhoods|Lumen_colasc_ColonAscendens_cell|MOLECULE|Drug absorption rate (lumen to mucosa)" id="338" />
-          <Map s="DA_trans_colasc" id="339" />
-          <Map s="..|..|ColonAscendens|Fractional steady state fill level" id="340" />
-          <Map s="..|..|ColonAscendens|Intestinal transit rate (absolute)" id="341" />
-          <Map s="..|..|ColonAscendens|Volume" id="342" />
-          <Map s="LT_coltrans" id="343" />
-          <Map s="..|..|ColonAscendens|Liquid transfer rate" id="344" />
-          <Map s="..|..|ColonDescendens|FillLevelFlag" id="345" />
-          <Map s="Neighborhoods|Lumen_coltrans_ColonTransversum_pls|MOLECULE|Drug absorption rate (lumen to mucosa)" id="346" />
-          <Map s="DA_para_coltrans" id="347" />
-          <Map s="Neighborhoods|Lumen_coltrans_ColonTransversum_cell|MOLECULE|Drug absorption rate (lumen to mucosa)" id="348" />
-          <Map s="DA_trans_coltrans" id="349" />
-          <Map s="LT_coldesc" id="350" />
-          <Map s="..|..|ColonTransversum|Liquid transfer rate" id="351" />
-          <Map s="..|..|ColonSigmoid|FillLevelFlag" id="352" />
-          <Map s="..|..|ColonTransversum|Fractional steady state fill level" id="353" />
-          <Map s="..|..|ColonTransversum|Intestinal transit rate (absolute)" id="354" />
-          <Map s="..|..|ColonTransversum|Volume" id="355" />
-          <Map s="Neighborhoods|Lumen_coldesc_ColonDescendens_pls|MOLECULE|Drug absorption rate (lumen to mucosa)" id="356" />
-          <Map s="DA_para_coldesc" id="357" />
-          <Map s="Neighborhoods|Lumen_coldesc_ColonDescendens_cell|MOLECULE|Drug absorption rate (lumen to mucosa)" id="358" />
-          <Map s="DA_trans_coldesc" id="359" />
-          <Map s="..|..|ColonDescendens|Fractional steady state fill level" id="360" />
-          <Map s="..|..|ColonDescendens|Intestinal transit rate (absolute)" id="361" />
-          <Map s="..|..|ColonDescendens|Volume" id="362" />
-          <Map s="LT_colsigm" id="363" />
-          <Map s="..|..|ColonDescendens|Liquid transfer rate" id="364" />
-          <Map s="..|..|Rectum|FillLevelFlag" id="365" />
-          <Map s="Neighborhoods|Lumen_colsigm_ColonSigmoid_pls|MOLECULE|Drug absorption rate (lumen to mucosa)" id="366" />
-          <Map s="DA_para_colsigm" id="367" />
-          <Map s="Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|MOLECULE|Drug absorption rate (lumen to mucosa)" id="368" />
-          <Map s="DA_trans_colsigm" id="369" />
-          <Map s="..|..|ColonSigmoid|Fractional steady state fill level" id="370" />
-          <Map s="..|..|ColonSigmoid|Intestinal transit rate (absolute)" id="371" />
-          <Map s="..|..|ColonSigmoid|Volume" id="372" />
-          <Map s="LT_rect" id="373" />
-          <Map s="..|..|ColonSigmoid|Liquid transfer rate" id="374" />
-          <Map s="Neighborhoods|Lumen_rect_Rectum_pls|MOLECULE|Drug absorption rate (lumen to mucosa)" id="375" />
-          <Map s="DA_para_rect" id="376" />
-          <Map s="Neighborhoods|Lumen_rect_Rectum_cell|MOLECULE|Drug absorption rate (lumen to mucosa)" id="377" />
-          <Map s="DA_trans_rect" id="378" />
-          <Map s="..|..|Rectum|Liquid transfer rate" id="379" />
-          <Map s="LT_rec" id="380" />
-          <Map s="Neighborhoods|Stomach_pls_Stomach_int|Surface area (plasma/interstitial)" id="381" />
-          <Map s="Neighborhoods|Stomach_int_Stomach_cell|MOLECULE|Partition coefficient (interstitial/water)" id="382" />
-          <Map s="Neighborhoods|Stomach_int_Stomach_cell|MOLECULE|Partition coefficient (intracellular/water)" id="383" />
-          <Map s="..|Colon arrival time" id="384" />
-          <Map s="Colon_Arrival_Time" id="385" />
-          <Map s="..|Colon_Arrival_Time_Intercept" id="386" />
-          <Map s="Colon_Arrival_Time_Intercept" id="387" />
-          <Map s="..|Colon_Arrival_Time_Slope" id="388" />
-          <Map s="Colon_Arrival_Time_Slope" id="389" />
-          <Map s="..|Colon_Arrival_Time_Slope_a0" id="390" />
-          <Map s="a0" id="391" />
-          <Map s="..|Colon_Arrival_Time_Slope_a1" id="392" />
-          <Map s="a1" id="393" />
-          <Map s="..|Colon_Arrival_Time_Slope_a2" id="394" />
-          <Map s="a2" id="395" />
-          <Map s="Organism|Lumen|Stomach|Gastric emptying time" id="396" />
-          <Map s="..|Colon_Arrival_Time_Intercept_a0" id="397" />
-          <Map s="..|Colon_Arrival_Time_Intercept_a1" id="398" />
-          <Map s="..|Lymph flow rate (incl. mucosa)" id="399" />
-          <Map s="Q_lymph_incl_Mucosa" id="400" />
-          <Map s="..|Mucosa|Duodenum|Lymph flow rate" id="401" />
-          <Map s="Q_lymph_duo" id="402" />
-          <Map s="..|Mucosa|LowerIleum|Lymph flow rate" id="403" />
-          <Map s="Q_lymph_lil" id="404" />
-          <Map s="..|Mucosa|LowerJejunum|Lymph flow rate" id="405" />
-          <Map s="Q_lymph_lje" id="406" />
-          <Map s="..|Mucosa|UpperIleum|Lymph flow rate" id="407" />
-          <Map s="Q_lymph_uil" id="408" />
-          <Map s="..|Mucosa|UpperJejunum|Lymph flow rate" id="409" />
-          <Map s="Q_lymph_uje" id="410" />
-          <Map s="Neighborhoods|SmallIntestine_pls_SmallIntestine_int|Surface area (plasma/interstitial)" id="411" />
-          <Map s="..|Fluid recirculation flow rate (incl. mucosa)" id="412" />
-          <Map s="J_iso_incl_Mucosa" id="413" />
-          <Map s="..|Mucosa|Duodenum|Fluid recirculation flow rate" id="414" />
-          <Map s="J_iso_duo" id="415" />
-          <Map s="..|Mucosa|LowerIleum|Fluid recirculation flow rate" id="416" />
-          <Map s="J_iso_lil" id="417" />
-          <Map s="..|Mucosa|LowerJejunum|Fluid recirculation flow rate" id="418" />
-          <Map s="J_iso_lje" id="419" />
-          <Map s="..|Mucosa|UpperIleum|Fluid recirculation flow rate" id="420" />
-          <Map s="J_iso_uil" id="421" />
-          <Map s="..|Mucosa|UpperJejunum|Fluid recirculation flow rate" id="422" />
-          <Map s="J_iso_uje" id="423" />
-          <Map s="..|Mucosa|Duodenum|Volume" id="424" />
-          <Map s="V_duo" id="425" />
-          <Map s="..|Mucosa|LowerIleum|Volume" id="426" />
-          <Map s="V_lil" id="427" />
-          <Map s="..|Mucosa|LowerJejunum|Volume" id="428" />
-          <Map s="V_lje" id="429" />
-          <Map s="..|Mucosa|UpperIleum|Volume" id="430" />
-          <Map s="V_uil" id="431" />
-          <Map s="..|Mucosa|UpperJejunum|Volume" id="432" />
-          <Map s="V_uje" id="433" />
-          <Map s="..|..|Volume (mucosa)" id="434" />
-          <Map s="V_Mucosa" id="435" />
-          <Map s="Neighborhoods|SmallIntestine_int_SmallIntestine_cell|MOLECULE|Partition coefficient (interstitial/water)" id="436" />
-          <Map s="Neighborhoods|SmallIntestine_int_SmallIntestine_cell|MOLECULE|Partition coefficient (intracellular/water)" id="437" />
-          <Map s="..|Fraction mucosa" id="438" />
-          <Map s="fractionMucosa" id="439" />
-          <Map s="..|..|..|..|Lumen|Duodenum|Volume (gut wall)" id="440" />
-          <Map s="V_GutWall" id="441" />
-          <Map s="..|..|..|Fluid recirculation flow rate (incl. mucosa)" id="442" />
-          <Map s="J_iso_intestine" id="443" />
-          <Map s="..|..|..|Volume" id="444" />
-          <Map s="V_intestine" id="445" />
-          <Map s="V_seg" id="446" />
-          <Map s="..|..|..|Lymph flow rate (incl. mucosa)" id="447" />
-          <Map s="Q_lymph_intestine" id="448" />
-          <Map s="Neighborhoods|Duodenum_pls_Duodenum_int|Surface area (plasma/interstitial)" id="449" />
-          <Map s="..|..|..|Blood flow rate" id="450" />
-          <Map s="Q" id="451" />
-          <Map s="..|Fraction of regional blood flow rate" id="452" />
-          <Map s="regionalFractQ" id="453" />
-          <Map s="..|..|..|Mucosa blood flow fraction" id="454" />
-          <Map s="fractQ" id="455" />
-          <Map s="Neighborhoods|Duodenum_int_Duodenum_cell|MOLECULE|Partition coefficient (interstitial/water)" id="456" />
-          <Map s="Neighborhoods|Duodenum_int_Duodenum_cell|MOLECULE|Partition coefficient (intracellular/water)" id="457" />
-          <Map s="..|..|..|..|Lumen|UpperJejunum|Volume (gut wall)" id="458" />
-          <Map s="Neighborhoods|UpperJejunum_pls_UpperJejunum_int|Surface area (plasma/interstitial)" id="459" />
-          <Map s="Neighborhoods|UpperJejunum_int_UpperJejunum_cell|MOLECULE|Partition coefficient (interstitial/water)" id="460" />
-          <Map s="Neighborhoods|UpperJejunum_int_UpperJejunum_cell|MOLECULE|Partition coefficient (intracellular/water)" id="461" />
-          <Map s="..|..|..|..|Lumen|LowerJejunum|Volume (gut wall)" id="462" />
-          <Map s="Neighborhoods|LowerJejunum_pls_LowerJejunum_int|Surface area (plasma/interstitial)" id="463" />
-          <Map s="Neighborhoods|LowerJejunum_int_LowerJejunum_cell|MOLECULE|Partition coefficient (interstitial/water)" id="464" />
-          <Map s="Neighborhoods|LowerJejunum_int_LowerJejunum_cell|MOLECULE|Partition coefficient (intracellular/water)" id="465" />
-          <Map s="..|..|..|..|Lumen|UpperIleum|Volume (gut wall)" id="466" />
-          <Map s="Neighborhoods|UpperIleum_pls_UpperIleum_int|Surface area (plasma/interstitial)" id="467" />
-          <Map s="Neighborhoods|UpperIleum_int_UpperIleum_cell|MOLECULE|Partition coefficient (interstitial/water)" id="468" />
-          <Map s="Neighborhoods|UpperIleum_int_UpperIleum_cell|MOLECULE|Partition coefficient (intracellular/water)" id="469" />
-          <Map s="..|..|..|..|Lumen|LowerIleum|Volume (gut wall)" id="470" />
-          <Map s="Neighborhoods|LowerIleum_pls_LowerIleum_int|Surface area (plasma/interstitial)" id="471" />
-          <Map s="Neighborhoods|LowerIleum_int_LowerIleum_cell|MOLECULE|Partition coefficient (interstitial/water)" id="472" />
-          <Map s="Neighborhoods|LowerIleum_int_LowerIleum_cell|MOLECULE|Partition coefficient (intracellular/water)" id="473" />
-          <Map s="..|Excretion time" id="474" />
-          <Map s="Excretion_Time" id="475" />
-          <Map s="..|Excretion_Time_k0" id="476" />
-          <Map s="Excretion_Time_k0" id="477" />
-          <Map s="..|Excretion_Time_k1" id="478" />
-          <Map s="Excretion_Time_k1" id="479" />
-          <Map s="..|Excretion_Time_k2" id="480" />
-          <Map s="Excretion_Time_k2" id="481" />
-          <Map s="Organism|SmallIntestine|Colon arrival time" id="482" />
-          <Map s="..|Mucosa|Caecum|Volume" id="483" />
-          <Map s="V_cae" id="484" />
-          <Map s="..|Mucosa|ColonAscendens|Volume" id="485" />
-          <Map s="V_ca" id="486" />
-          <Map s="..|Mucosa|ColonDescendens|Volume" id="487" />
-          <Map s="V_cd" id="488" />
-          <Map s="..|Mucosa|ColonSigmoid|Volume" id="489" />
-          <Map s="V_cs" id="490" />
-          <Map s="..|Mucosa|ColonTransversum|Volume" id="491" />
-          <Map s="V_ct" id="492" />
-          <Map s="..|Mucosa|Rectum|Volume" id="493" />
-          <Map s="V_rec" id="494" />
-          <Map s="Neighborhoods|LargeIntestine_pls_LargeIntestine_int|Surface area (plasma/interstitial)" id="495" />
-          <Map s="..|Mucosa|Caecum|Lymph flow rate" id="496" />
-          <Map s="Q_lymph_cae" id="497" />
-          <Map s="..|Mucosa|ColonAscendens|Lymph flow rate" id="498" />
-          <Map s="Q_lymph_colasc" id="499" />
-          <Map s="..|Mucosa|ColonDescendens|Lymph flow rate" id="500" />
-          <Map s="Q_lymph_coldesc" id="501" />
-          <Map s="..|Mucosa|ColonSigmoid|Lymph flow rate" id="502" />
-          <Map s="Q_lymph_colsigm" id="503" />
-          <Map s="..|Mucosa|ColonTransversum|Lymph flow rate" id="504" />
-          <Map s="Q_lymph_coltrans" id="505" />
-          <Map s="..|Mucosa|Rectum|Lymph flow rate" id="506" />
-          <Map s="Q_lymph_rect" id="507" />
-          <Map s="..|Mucosa|Caecum|Fluid recirculation flow rate" id="508" />
-          <Map s="J_iso_cae" id="509" />
-          <Map s="..|Mucosa|ColonAscendens|Fluid recirculation flow rate" id="510" />
-          <Map s="J_iso_colasc" id="511" />
-          <Map s="..|Mucosa|ColonDescendens|Fluid recirculation flow rate" id="512" />
-          <Map s="J_iso_coldesc" id="513" />
-          <Map s="..|Mucosa|ColonSigmoid|Fluid recirculation flow rate" id="514" />
-          <Map s="J_iso_colsigm" id="515" />
-          <Map s="..|Mucosa|ColonTransversum|Fluid recirculation flow rate" id="516" />
-          <Map s="J_iso_coltrans" id="517" />
-          <Map s="..|Mucosa|Rectum|Fluid recirculation flow rate" id="518" />
-          <Map s="J_iso_rect" id="519" />
-          <Map s="Neighborhoods|LargeIntestine_int_LargeIntestine_cell|MOLECULE|Partition coefficient (interstitial/water)" id="520" />
-          <Map s="Neighborhoods|LargeIntestine_int_LargeIntestine_cell|MOLECULE|Partition coefficient (intracellular/water)" id="521" />
-          <Map s="..|..|..|..|Lumen|Caecum|Volume (gut wall)" id="522" />
-          <Map s="Neighborhoods|Caecum_pls_Caecum_int|Surface area (plasma/interstitial)" id="523" />
-          <Map s="Neighborhoods|Caecum_int_Caecum_cell|MOLECULE|Partition coefficient (interstitial/water)" id="524" />
-          <Map s="Neighborhoods|Caecum_int_Caecum_cell|MOLECULE|Partition coefficient (intracellular/water)" id="525" />
-          <Map s="..|..|..|..|Lumen|ColonAscendens|Volume (gut wall)" id="526" />
-          <Map s="Neighborhoods|ColonAscendens_pls_ColonAscendens_int|Surface area (plasma/interstitial)" id="527" />
-          <Map s="Neighborhoods|ColonAscendens_int_ColonAscendens_cell|MOLECULE|Partition coefficient (interstitial/water)" id="528" />
-          <Map s="Neighborhoods|ColonAscendens_int_ColonAscendens_cell|MOLECULE|Partition coefficient (intracellular/water)" id="529" />
-          <Map s="..|..|..|..|Lumen|ColonTransversum|Volume (gut wall)" id="530" />
-          <Map s="Neighborhoods|ColonTransversum_pls_ColonTransversum_int|Surface area (plasma/interstitial)" id="531" />
-          <Map s="Neighborhoods|ColonTransversum_int_ColonTransversum_cell|MOLECULE|Partition coefficient (interstitial/water)" id="532" />
-          <Map s="Neighborhoods|ColonTransversum_int_ColonTransversum_cell|MOLECULE|Partition coefficient (intracellular/water)" id="533" />
-          <Map s="..|..|..|..|Lumen|ColonDescendens|Volume (gut wall)" id="534" />
-          <Map s="Neighborhoods|ColonDescendens_pls_ColonDescendens_int|Surface area (plasma/interstitial)" id="535" />
-          <Map s="Neighborhoods|ColonDescendens_int_ColonDescendens_cell|MOLECULE|Partition coefficient (interstitial/water)" id="536" />
-          <Map s="Neighborhoods|ColonDescendens_int_ColonDescendens_cell|MOLECULE|Partition coefficient (intracellular/water)" id="537" />
-          <Map s="..|..|..|..|Lumen|ColonSigmoid|Volume (gut wall)" id="538" />
-          <Map s="Neighborhoods|ColonSigmoid_pls_ColonSigmoid_int|Surface area (plasma/interstitial)" id="539" />
-          <Map s="Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|MOLECULE|Partition coefficient (interstitial/water)" id="540" />
-          <Map s="Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|MOLECULE|Partition coefficient (intracellular/water)" id="541" />
-          <Map s="..|..|..|..|Lumen|Rectum|Volume (gut wall)" id="542" />
-          <Map s="Neighborhoods|Rectum_pls_Rectum_int|Surface area (plasma/interstitial)" id="543" />
-          <Map s="Neighborhoods|Rectum_int_Rectum_cell|MOLECULE|Partition coefficient (interstitial/water)" id="544" />
-          <Map s="Neighborhoods|Rectum_int_Rectum_cell|MOLECULE|Partition coefficient (intracellular/water)" id="545" />
-          <Map s="Neighborhoods|Liver_pls_Liver_int|Surface area (plasma/interstitial)" id="546" />
-          <Map s="Neighborhoods|Liver_int_Liver_cell|MOLECULE|Partition coefficient (interstitial/water)" id="547" />
-          <Map s="Neighborhoods|Liver_int_Liver_cell|MOLECULE|Partition coefficient (intracellular/water)" id="548" />
-          <Map s="Neighborhoods|Lung_pls_Lung_int|Surface area (plasma/interstitial)" id="549" />
-          <Map s="Organism|Bone|Blood flow rate" id="550" />
-          <Map s="Q_bon" id="551" />
-          <Map s="Organism|Brain|Blood flow rate" id="552" />
-          <Map s="Q_brn" id="553" />
-          <Map s="Organism|Fat|Blood flow rate" id="554" />
-          <Map s="Q_fat" id="555" />
-          <Map s="Organism|Gonads|Blood flow rate" id="556" />
-          <Map s="Q_tes" id="557" />
-          <Map s="Organism|Heart|Blood flow rate" id="558" />
-          <Map s="Q_hrt" id="559" />
-          <Map s="Organism|Kidney|Blood flow rate" id="560" />
-          <Map s="Q_kid" id="561" />
-          <Map s="Organism|LargeIntestine|Blood flow rate" id="562" />
-          <Map s="Q_lin" id="563" />
-          <Map s="Organism|Liver|Blood flow rate" id="564" />
-          <Map s="Q_liv" id="565" />
-          <Map s="Organism|Muscle|Blood flow rate" id="566" />
-          <Map s="Q_mus" id="567" />
-          <Map s="Organism|Pancreas|Blood flow rate" id="568" />
-          <Map s="Q_pan" id="569" />
-          <Map s="Organism|Skin|Blood flow rate" id="570" />
-          <Map s="Q_skn" id="571" />
-          <Map s="Organism|SmallIntestine|Blood flow rate" id="572" />
-          <Map s="Q_sin" id="573" />
-          <Map s="Organism|Spleen|Blood flow rate" id="574" />
-          <Map s="Q_spl" id="575" />
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-        <ParameterStartValue startValue="100">
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-        <ParameterStartValue startValue="100">
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-        <ParameterStartValue startValue="100">
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-        <ParameterStartValue startValue="100">
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-        <ParameterStartValue startValue="100">
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-        <ParameterStartValue startValue="100">
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-        <ParameterStartValue startValue="100">
-          <ParameterPath path="1837" />
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-        <ParameterStartValue startValue="100">
-          <ParameterPath path="1838" />
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-        <ParameterStartValue startValue="100">
-          <ParameterPath path="1839" />
-        </ParameterStartValue>
-        <ParameterStartValue startValue="100">
-          <ParameterPath path="1840" />
-        </ParameterStartValue>
-        <ParameterStartValue startValue="100">
-          <ParameterPath path="1841" />
-        </ParameterStartValue>
-        <ParameterStartValue startValue="100">
-          <ParameterPath path="1842" />
-        </ParameterStartValue>
-        <ParameterStartValue startValue="100">
-          <ParameterPath path="1843" />
-        </ParameterStartValue>
-        <ParameterStartValue startValue="100">
-          <ParameterPath path="1844" />
-        </ParameterStartValue>
-        <ParameterStartValue startValue="100">
-          <ParameterPath path="1845" />
-        </ParameterStartValue>
-        <ParameterStartValue startValue="100">
-          <ParameterPath path="1846" />
-        </ParameterStartValue>
-        <ParameterStartValue startValue="100">
-          <ParameterPath path="1847" />
-        </ParameterStartValue>
-        <ParameterStartValue startValue="100">
-          <ParameterPath path="1848" />
-        </ParameterStartValue>
-        <ParameterStartValue startValue="100">
-          <ParameterPath path="1849" />
-        </ParameterStartValue>
-        <ParameterStartValue startValue="100">
-          <ParameterPath path="1850" />
-        </ParameterStartValue>
-        <ParameterStartValue startValue="100">
-          <ParameterPath path="1851" />
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-        <ParameterStartValue startValue="100">
-          <ParameterPath path="1852" />
-        </ParameterStartValue>
-        <ParameterStartValue startValue="100">
-          <ParameterPath path="1853" />
-        </ParameterStartValue>
-        <ParameterStartValue startValue="100">
-          <ParameterPath path="1854" />
-        </ParameterStartValue>
-        <ParameterStartValue startValue="100">
-          <ParameterPath path="1855" />
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-        <ParameterStartValue startValue="100">
-          <ParameterPath path="1856" />
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-        <ParameterStartValue startValue="100">
-          <ParameterPath path="1857" />
-        </ParameterStartValue>
-        <ParameterStartValue startValue="100">
-          <ParameterPath path="1858" />
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-        <ParameterStartValue startValue="100">
-          <ParameterPath path="1859" />
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-        <ParameterStartValue startValue="100">
-          <ParameterPath path="1860" />
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-        <ParameterStartValue startValue="100">
-          <ParameterPath path="1861" />
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-        <ParameterStartValue startValue="100">
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-        <ParameterStartValue startValue="100">
-          <ParameterPath path="1863" />
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-        <ParameterStartValue startValue="100">
-          <ParameterPath path="1864" />
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-            </Paths>
-          </Formula>
-          <Formula id="ActiveProcess_PKSim.RelExpBloodCellsGlobal" name="RelExpBloodCellsGlobal" dim="Dimensionless" formula="rel_exp_bc">
-            <Paths>
-              <Path path="1868" as="1869" dim="1867" />
-            </Paths>
-          </Formula>
-          <Formula id="ActiveProcess_PKSim.RelExpOutFromNorm" name="RelExpOutFromNorm" dim="Dimensionless" formula="rel_exp_norm">
-            <Paths>
-              <Path path="1870" as="1871" dim="1867" />
-            </Paths>
-          </Formula>
-          <Formula id="ActiveProcess_PKSim.RelExpPlasmaNormGlobal" name="RelExpPlasmaNormGlobal" dim="Dimensionless" formula="rel_exp_pls_norm">
-            <Paths>
-              <Path path="1872" as="1873" dim="1867" />
-            </Paths>
-          </Formula>
-          <Formula id="ActiveProcess_PKSim.RelExpPlasmaGlobal" name="RelExpPlasmaGlobal" dim="Dimensionless" formula="rel_exp_pls">
-            <Paths>
-              <Path path="1874" as="1875" dim="1867" />
-            </Paths>
-          </Formula>
-        </Formulas>
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-          <Map s="Organism|VenousBlood|BloodCells|Cyp|Ontogeny factor" id="2" />
-          <Map s="Organism|ArterialBlood|Plasma|Cyp|Ontogeny factor" id="3" />
-          <Map s="Organism|ArterialBlood|BloodCells|Cyp|Ontogeny factor" id="4" />
-          <Map s="Organism|Bone|Plasma|Cyp|Ontogeny factor" id="5" />
-          <Map s="Organism|Bone|BloodCells|Cyp|Ontogeny factor" id="6" />
-          <Map s="Organism|Bone|Interstitial|Cyp|Ontogeny factor" id="7" />
-          <Map s="Organism|Bone|Intracellular|Cyp|Ontogeny factor" id="8" />
-          <Map s="Organism|Brain|Plasma|Cyp|Ontogeny factor" id="9" />
-          <Map s="Organism|Brain|BloodCells|Cyp|Ontogeny factor" id="10" />
-          <Map s="Organism|Brain|Interstitial|Cyp|Ontogeny factor" id="11" />
-          <Map s="Organism|Brain|Intracellular|Cyp|Ontogeny factor" id="12" />
-          <Map s="Organism|Fat|Plasma|Cyp|Ontogeny factor" id="13" />
-          <Map s="Organism|Fat|BloodCells|Cyp|Ontogeny factor" id="14" />
-          <Map s="Organism|Fat|Interstitial|Cyp|Ontogeny factor" id="15" />
-          <Map s="Organism|Fat|Intracellular|Cyp|Ontogeny factor" id="16" />
-          <Map s="Organism|Gonads|Plasma|Cyp|Ontogeny factor" id="17" />
-          <Map s="Organism|Gonads|BloodCells|Cyp|Ontogeny factor" id="18" />
-          <Map s="Organism|Gonads|Interstitial|Cyp|Ontogeny factor" id="19" />
-          <Map s="Organism|Gonads|Intracellular|Cyp|Ontogeny factor" id="20" />
-          <Map s="Organism|Heart|Plasma|Cyp|Ontogeny factor" id="21" />
-          <Map s="Organism|Heart|BloodCells|Cyp|Ontogeny factor" id="22" />
-          <Map s="Organism|Heart|Interstitial|Cyp|Ontogeny factor" id="23" />
-          <Map s="Organism|Heart|Intracellular|Cyp|Ontogeny factor" id="24" />
-          <Map s="Organism|Kidney|Plasma|Cyp|Ontogeny factor" id="25" />
-          <Map s="Organism|Kidney|BloodCells|Cyp|Ontogeny factor" id="26" />
-          <Map s="Organism|Kidney|Interstitial|Cyp|Ontogeny factor" id="27" />
-          <Map s="Organism|Kidney|Intracellular|Cyp|Ontogeny factor" id="28" />
-          <Map s="Organism|Kidney|Urine|Cyp|Ontogeny factor" id="29" />
-          <Map s="Organism|Lumen|Stomach|Cyp|Ontogeny factor" id="30" />
-          <Map s="Organism|Lumen|Duodenum|Cyp|Ontogeny factor" id="31" />
-          <Map s="Organism|Lumen|UpperJejunum|Cyp|Ontogeny factor" id="32" />
-          <Map s="Organism|Lumen|LowerJejunum|Cyp|Ontogeny factor" id="33" />
-          <Map s="Organism|Lumen|UpperIleum|Cyp|Ontogeny factor" id="34" />
-          <Map s="Organism|Lumen|LowerIleum|Cyp|Ontogeny factor" id="35" />
-          <Map s="Organism|Lumen|Caecum|Cyp|Ontogeny factor" id="36" />
-          <Map s="Organism|Lumen|ColonAscendens|Cyp|Ontogeny factor" id="37" />
-          <Map s="Organism|Lumen|ColonTransversum|Cyp|Ontogeny factor" id="38" />
-          <Map s="Organism|Lumen|ColonDescendens|Cyp|Ontogeny factor" id="39" />
-          <Map s="Organism|Lumen|ColonSigmoid|Cyp|Ontogeny factor" id="40" />
-          <Map s="Organism|Lumen|Rectum|Cyp|Ontogeny factor" id="41" />
-          <Map s="Organism|Lumen|Feces|Cyp|Ontogeny factor" id="42" />
-          <Map s="Organism|Stomach|Plasma|Cyp|Ontogeny factor" id="43" />
-          <Map s="Organism|Stomach|BloodCells|Cyp|Ontogeny factor" id="44" />
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-          <Map s="Organism|Stomach|Intracellular|Cyp|Ontogeny factor" id="46" />
-          <Map s="Organism|SmallIntestine|Plasma|Cyp|Ontogeny factor" id="47" />
-          <Map s="Organism|SmallIntestine|BloodCells|Cyp|Ontogeny factor" id="48" />
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-          <Map s="Organism|SmallIntestine|Intracellular|Cyp|Ontogeny factor" id="50" />
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-          <Map s="Organism|LargeIntestine|Mucosa|Rectum|Intracellular|Cyp|Ontogeny factor" id="98" />
-          <Map s="Organism|Liver|Plasma|Cyp|Ontogeny factor" id="99" />
-          <Map s="Organism|Liver|BloodCells|Cyp|Ontogeny factor" id="100" />
-          <Map s="Organism|Liver|Interstitial|Cyp|Ontogeny factor" id="101" />
-          <Map s="Organism|Liver|Intracellular|Cyp|Ontogeny factor" id="102" />
-          <Map s="Organism|Lung|Plasma|Cyp|Ontogeny factor" id="103" />
-          <Map s="Organism|Lung|BloodCells|Cyp|Ontogeny factor" id="104" />
-          <Map s="Organism|Lung|Interstitial|Cyp|Ontogeny factor" id="105" />
-          <Map s="Organism|Lung|Intracellular|Cyp|Ontogeny factor" id="106" />
-          <Map s="Organism|Muscle|Plasma|Cyp|Ontogeny factor" id="107" />
-          <Map s="Organism|Muscle|BloodCells|Cyp|Ontogeny factor" id="108" />
-          <Map s="Organism|Muscle|Interstitial|Cyp|Ontogeny factor" id="109" />
-          <Map s="Organism|Muscle|Intracellular|Cyp|Ontogeny factor" id="110" />
-          <Map s="Organism|Pancreas|Plasma|Cyp|Ontogeny factor" id="111" />
-          <Map s="Organism|Pancreas|BloodCells|Cyp|Ontogeny factor" id="112" />
-          <Map s="Organism|Pancreas|Interstitial|Cyp|Ontogeny factor" id="113" />
-          <Map s="Organism|Pancreas|Intracellular|Cyp|Ontogeny factor" id="114" />
-          <Map s="Organism|PortalVein|Plasma|Cyp|Ontogeny factor" id="115" />
-          <Map s="Organism|PortalVein|BloodCells|Cyp|Ontogeny factor" id="116" />
-          <Map s="Organism|Skin|Plasma|Cyp|Ontogeny factor" id="117" />
-          <Map s="Organism|Skin|BloodCells|Cyp|Ontogeny factor" id="118" />
-          <Map s="Organism|Skin|Interstitial|Cyp|Ontogeny factor" id="119" />
-          <Map s="Organism|Skin|Intracellular|Cyp|Ontogeny factor" id="120" />
-          <Map s="Organism|Spleen|Plasma|Cyp|Ontogeny factor" id="121" />
-          <Map s="Organism|Spleen|BloodCells|Cyp|Ontogeny factor" id="122" />
-          <Map s="Organism|Spleen|Interstitial|Cyp|Ontogeny factor" id="123" />
-          <Map s="Organism|Spleen|Intracellular|Cyp|Ontogeny factor" id="124" />
-          <Map s="Organism|Saliva|Saliva|Cyp|Ontogeny factor" id="125" />
-          <Map s="Organism|Saliva|SalivaGland|Cyp|Ontogeny factor" id="126" />
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-          <Map s="Organism|VenousBlood|BloodCells|Cyp|Relative expression out." id="130" />
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-          <Map s="Organism|ArterialBlood|BloodCells|Cyp|Relative expression out." id="132" />
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-          <Map s="Organism|Bone|BloodCells|Cyp|Relative expression out." id="134" />
-          <Map s="Organism|Bone|Interstitial|Cyp|Relative expression out." id="135" />
-          <Map s="Organism|Bone|Intracellular|Cyp|Relative expression out." id="136" />
-          <Map s="Organism|Brain|Plasma|Cyp|Relative expression out." id="137" />
-          <Map s="Organism|Brain|BloodCells|Cyp|Relative expression out." id="138" />
-          <Map s="Organism|Brain|Interstitial|Cyp|Relative expression out." id="139" />
-          <Map s="Organism|Brain|Intracellular|Cyp|Relative expression out." id="140" />
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-          <Map s="Organism|Fat|BloodCells|Cyp|Relative expression out." id="142" />
-          <Map s="Organism|Fat|Interstitial|Cyp|Relative expression out." id="143" />
-          <Map s="Organism|Fat|Intracellular|Cyp|Relative expression out." id="144" />
-          <Map s="Organism|Gonads|Plasma|Cyp|Relative expression out." id="145" />
-          <Map s="Organism|Gonads|BloodCells|Cyp|Relative expression out." id="146" />
-          <Map s="Organism|Gonads|Interstitial|Cyp|Relative expression out." id="147" />
-          <Map s="Organism|Gonads|Intracellular|Cyp|Relative expression out." id="148" />
-          <Map s="Organism|Heart|Plasma|Cyp|Relative expression out." id="149" />
-          <Map s="Organism|Heart|BloodCells|Cyp|Relative expression out." id="150" />
-          <Map s="Organism|Heart|Interstitial|Cyp|Relative expression out." id="151" />
-          <Map s="Organism|Heart|Intracellular|Cyp|Relative expression out." id="152" />
-          <Map s="Organism|Kidney|Plasma|Cyp|Relative expression out." id="153" />
-          <Map s="Organism|Kidney|BloodCells|Cyp|Relative expression out." id="154" />
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-          <Map s="Organism|Kidney|Intracellular|Cyp|Relative expression out." id="156" />
-          <Map s="Organism|Kidney|Urine|Cyp|Relative expression out." id="157" />
-          <Map s="Organism|Lumen|Stomach|Cyp|Relative expression out." id="158" />
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-          <Map s="Organism|Lumen|UpperIleum|Cyp|Relative expression out." id="162" />
-          <Map s="Organism|Lumen|LowerIleum|Cyp|Relative expression out." id="163" />
-          <Map s="Organism|Lumen|Caecum|Cyp|Relative expression out." id="164" />
-          <Map s="Organism|Lumen|ColonAscendens|Cyp|Relative expression out." id="165" />
-          <Map s="Organism|Lumen|ColonTransversum|Cyp|Relative expression out." id="166" />
-          <Map s="Organism|Lumen|ColonDescendens|Cyp|Relative expression out." id="167" />
-          <Map s="Organism|Lumen|ColonSigmoid|Cyp|Relative expression out." id="168" />
-          <Map s="Organism|Lumen|Rectum|Cyp|Relative expression out." id="169" />
-          <Map s="Organism|Lumen|Feces|Cyp|Relative expression out." id="170" />
-          <Map s="Organism|Stomach|Plasma|Cyp|Relative expression out." id="171" />
-          <Map s="Organism|Stomach|BloodCells|Cyp|Relative expression out." id="172" />
-          <Map s="Organism|Stomach|Interstitial|Cyp|Relative expression out." id="173" />
-          <Map s="Organism|Stomach|Intracellular|Cyp|Relative expression out." id="174" />
-          <Map s="Organism|SmallIntestine|Plasma|Cyp|Relative expression out." id="175" />
-          <Map s="Organism|SmallIntestine|BloodCells|Cyp|Relative expression out." id="176" />
-          <Map s="Organism|SmallIntestine|Interstitial|Cyp|Relative expression out." id="177" />
-          <Map s="Organism|SmallIntestine|Intracellular|Cyp|Relative expression out." id="178" />
-          <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Plasma|Cyp|Relative expression out." id="179" />
-          <Map s="Organism|SmallIntestine|Mucosa|Duodenum|BloodCells|Cyp|Relative expression out." id="180" />
-          <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Interstitial|Cyp|Relative expression out." id="181" />
-          <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|Cyp|Relative expression out." id="182" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Plasma|Cyp|Relative expression out." id="183" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|BloodCells|Cyp|Relative expression out." id="184" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Interstitial|Cyp|Relative expression out." id="185" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|Cyp|Relative expression out." id="186" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Plasma|Cyp|Relative expression out." id="187" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|BloodCells|Cyp|Relative expression out." id="188" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Interstitial|Cyp|Relative expression out." id="189" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|Cyp|Relative expression out." id="190" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Plasma|Cyp|Relative expression out." id="191" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|BloodCells|Cyp|Relative expression out." id="192" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Interstitial|Cyp|Relative expression out." id="193" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|Cyp|Relative expression out." id="194" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Plasma|Cyp|Relative expression out." id="195" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|BloodCells|Cyp|Relative expression out." id="196" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Interstitial|Cyp|Relative expression out." id="197" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|Cyp|Relative expression out." id="198" />
-          <Map s="Organism|LargeIntestine|Plasma|Cyp|Relative expression out." id="199" />
-          <Map s="Organism|LargeIntestine|BloodCells|Cyp|Relative expression out." id="200" />
-          <Map s="Organism|LargeIntestine|Interstitial|Cyp|Relative expression out." id="201" />
-          <Map s="Organism|LargeIntestine|Intracellular|Cyp|Relative expression out." id="202" />
-          <Map s="Organism|LargeIntestine|Mucosa|Caecum|Plasma|Cyp|Relative expression out." id="203" />
-          <Map s="Organism|LargeIntestine|Mucosa|Caecum|BloodCells|Cyp|Relative expression out." id="204" />
-          <Map s="Organism|LargeIntestine|Mucosa|Caecum|Interstitial|Cyp|Relative expression out." id="205" />
-          <Map s="Organism|LargeIntestine|Mucosa|Caecum|Intracellular|Cyp|Relative expression out." id="206" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonAscendens|Plasma|Cyp|Relative expression out." id="207" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonAscendens|BloodCells|Cyp|Relative expression out." id="208" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonAscendens|Interstitial|Cyp|Relative expression out." id="209" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|Cyp|Relative expression out." id="210" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonTransversum|Plasma|Cyp|Relative expression out." id="211" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonTransversum|BloodCells|Cyp|Relative expression out." id="212" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonTransversum|Interstitial|Cyp|Relative expression out." id="213" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|Cyp|Relative expression out." id="214" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonDescendens|Plasma|Cyp|Relative expression out." id="215" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonDescendens|BloodCells|Cyp|Relative expression out." id="216" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonDescendens|Interstitial|Cyp|Relative expression out." id="217" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|Cyp|Relative expression out." id="218" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonSigmoid|Plasma|Cyp|Relative expression out." id="219" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonSigmoid|BloodCells|Cyp|Relative expression out." id="220" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonSigmoid|Interstitial|Cyp|Relative expression out." id="221" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|Cyp|Relative expression out." id="222" />
-          <Map s="Organism|LargeIntestine|Mucosa|Rectum|Plasma|Cyp|Relative expression out." id="223" />
-          <Map s="Organism|LargeIntestine|Mucosa|Rectum|BloodCells|Cyp|Relative expression out." id="224" />
-          <Map s="Organism|LargeIntestine|Mucosa|Rectum|Interstitial|Cyp|Relative expression out." id="225" />
-          <Map s="Organism|LargeIntestine|Mucosa|Rectum|Intracellular|Cyp|Relative expression out." id="226" />
-          <Map s="Organism|Liver|Plasma|Cyp|Relative expression out." id="227" />
-          <Map s="Organism|Liver|BloodCells|Cyp|Relative expression out." id="228" />
-          <Map s="Organism|Liver|Interstitial|Cyp|Relative expression out." id="229" />
-          <Map s="Organism|Liver|Intracellular|Cyp|Relative expression out." id="230" />
-          <Map s="Organism|Lung|Plasma|Cyp|Relative expression out." id="231" />
-          <Map s="Organism|Lung|BloodCells|Cyp|Relative expression out." id="232" />
-          <Map s="Organism|Lung|Interstitial|Cyp|Relative expression out." id="233" />
-          <Map s="Organism|Lung|Intracellular|Cyp|Relative expression out." id="234" />
-          <Map s="Organism|Muscle|Plasma|Cyp|Relative expression out." id="235" />
-          <Map s="Organism|Muscle|BloodCells|Cyp|Relative expression out." id="236" />
-          <Map s="Organism|Muscle|Interstitial|Cyp|Relative expression out." id="237" />
-          <Map s="Organism|Muscle|Intracellular|Cyp|Relative expression out." id="238" />
-          <Map s="Organism|Pancreas|Plasma|Cyp|Relative expression out." id="239" />
-          <Map s="Organism|Pancreas|BloodCells|Cyp|Relative expression out." id="240" />
-          <Map s="Organism|Pancreas|Interstitial|Cyp|Relative expression out." id="241" />
-          <Map s="Organism|Pancreas|Intracellular|Cyp|Relative expression out." id="242" />
-          <Map s="Organism|PortalVein|Plasma|Cyp|Relative expression out." id="243" />
-          <Map s="Organism|PortalVein|BloodCells|Cyp|Relative expression out." id="244" />
-          <Map s="Organism|Skin|Plasma|Cyp|Relative expression out." id="245" />
-          <Map s="Organism|Skin|BloodCells|Cyp|Relative expression out." id="246" />
-          <Map s="Organism|Skin|Interstitial|Cyp|Relative expression out." id="247" />
-          <Map s="Organism|Skin|Intracellular|Cyp|Relative expression out." id="248" />
-          <Map s="Organism|Spleen|Plasma|Cyp|Relative expression out." id="249" />
-          <Map s="Organism|Spleen|BloodCells|Cyp|Relative expression out." id="250" />
-          <Map s="Organism|Spleen|Interstitial|Cyp|Relative expression out." id="251" />
-          <Map s="Organism|Spleen|Intracellular|Cyp|Relative expression out." id="252" />
-          <Map s="Organism|Saliva|Saliva|Cyp|Relative expression out." id="253" />
-          <Map s="Organism|Saliva|SalivaGland|Cyp|Relative expression out." id="254" />
-          <Map s="Cyp|Relative expression in vascular endothelium" id="255" />
-          <Map s="Cyp|Relative expression in plasma" id="256" />
-          <Map s="Cyp|Relative expression in blood cells" id="257" />
-          <Map s="Organism|Gallbladder|Cyp|Relative expression (normalized)" id="258" />
-          <Map s="Organism|VenousBlood|Plasma|Cyp|Relative expression (normalized)" id="259" />
-          <Map s="Organism|VenousBlood|BloodCells|Cyp|Relative expression (normalized)" id="260" />
-          <Map s="Organism|ArterialBlood|Plasma|Cyp|Relative expression (normalized)" id="261" />
-          <Map s="Organism|ArterialBlood|BloodCells|Cyp|Relative expression (normalized)" id="262" />
-          <Map s="Organism|Bone|Plasma|Cyp|Relative expression (normalized)" id="263" />
-          <Map s="Organism|Bone|BloodCells|Cyp|Relative expression (normalized)" id="264" />
-          <Map s="Organism|Bone|Interstitial|Cyp|Relative expression (normalized)" id="265" />
-          <Map s="Organism|Bone|Intracellular|Cyp|Relative expression (normalized)" id="266" />
-          <Map s="Organism|Brain|Plasma|Cyp|Relative expression (normalized)" id="267" />
-          <Map s="Organism|Brain|BloodCells|Cyp|Relative expression (normalized)" id="268" />
-          <Map s="Organism|Brain|Interstitial|Cyp|Relative expression (normalized)" id="269" />
-          <Map s="Organism|Brain|Intracellular|Cyp|Relative expression (normalized)" id="270" />
-          <Map s="Organism|Fat|Plasma|Cyp|Relative expression (normalized)" id="271" />
-          <Map s="Organism|Fat|BloodCells|Cyp|Relative expression (normalized)" id="272" />
-          <Map s="Organism|Fat|Interstitial|Cyp|Relative expression (normalized)" id="273" />
-          <Map s="Organism|Fat|Intracellular|Cyp|Relative expression (normalized)" id="274" />
-          <Map s="Organism|Gonads|Plasma|Cyp|Relative expression (normalized)" id="275" />
-          <Map s="Organism|Gonads|BloodCells|Cyp|Relative expression (normalized)" id="276" />
-          <Map s="Organism|Gonads|Interstitial|Cyp|Relative expression (normalized)" id="277" />
-          <Map s="Organism|Gonads|Intracellular|Cyp|Relative expression (normalized)" id="278" />
-          <Map s="Organism|Heart|Plasma|Cyp|Relative expression (normalized)" id="279" />
-          <Map s="Organism|Heart|BloodCells|Cyp|Relative expression (normalized)" id="280" />
-          <Map s="Organism|Heart|Interstitial|Cyp|Relative expression (normalized)" id="281" />
-          <Map s="Organism|Heart|Intracellular|Cyp|Relative expression (normalized)" id="282" />
-          <Map s="Organism|Kidney|Plasma|Cyp|Relative expression (normalized)" id="283" />
-          <Map s="Organism|Kidney|BloodCells|Cyp|Relative expression (normalized)" id="284" />
-          <Map s="Organism|Kidney|Interstitial|Cyp|Relative expression (normalized)" id="285" />
-          <Map s="Organism|Kidney|Intracellular|Cyp|Relative expression (normalized)" id="286" />
-          <Map s="Organism|Kidney|Urine|Cyp|Relative expression (normalized)" id="287" />
-          <Map s="Organism|Lumen|Stomach|Cyp|Relative expression (normalized)" id="288" />
-          <Map s="Organism|Lumen|Duodenum|Cyp|Relative expression (normalized)" id="289" />
-          <Map s="Organism|Lumen|UpperJejunum|Cyp|Relative expression (normalized)" id="290" />
-          <Map s="Organism|Lumen|LowerJejunum|Cyp|Relative expression (normalized)" id="291" />
-          <Map s="Organism|Lumen|UpperIleum|Cyp|Relative expression (normalized)" id="292" />
-          <Map s="Organism|Lumen|LowerIleum|Cyp|Relative expression (normalized)" id="293" />
-          <Map s="Organism|Lumen|Caecum|Cyp|Relative expression (normalized)" id="294" />
-          <Map s="Organism|Lumen|ColonAscendens|Cyp|Relative expression (normalized)" id="295" />
-          <Map s="Organism|Lumen|ColonTransversum|Cyp|Relative expression (normalized)" id="296" />
-          <Map s="Organism|Lumen|ColonDescendens|Cyp|Relative expression (normalized)" id="297" />
-          <Map s="Organism|Lumen|ColonSigmoid|Cyp|Relative expression (normalized)" id="298" />
-          <Map s="Organism|Lumen|Rectum|Cyp|Relative expression (normalized)" id="299" />
-          <Map s="Organism|Lumen|Feces|Cyp|Relative expression (normalized)" id="300" />
-          <Map s="Organism|Stomach|Plasma|Cyp|Relative expression (normalized)" id="301" />
-          <Map s="Organism|Stomach|BloodCells|Cyp|Relative expression (normalized)" id="302" />
-          <Map s="Organism|Stomach|Interstitial|Cyp|Relative expression (normalized)" id="303" />
-          <Map s="Organism|Stomach|Intracellular|Cyp|Relative expression (normalized)" id="304" />
-          <Map s="Organism|SmallIntestine|Plasma|Cyp|Relative expression (normalized)" id="305" />
-          <Map s="Organism|SmallIntestine|BloodCells|Cyp|Relative expression (normalized)" id="306" />
-          <Map s="Organism|SmallIntestine|Interstitial|Cyp|Relative expression (normalized)" id="307" />
-          <Map s="Organism|SmallIntestine|Intracellular|Cyp|Relative expression (normalized)" id="308" />
-          <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Plasma|Cyp|Relative expression (normalized)" id="309" />
-          <Map s="Organism|SmallIntestine|Mucosa|Duodenum|BloodCells|Cyp|Relative expression (normalized)" id="310" />
-          <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Interstitial|Cyp|Relative expression (normalized)" id="311" />
-          <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|Cyp|Relative expression (normalized)" id="312" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Plasma|Cyp|Relative expression (normalized)" id="313" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|BloodCells|Cyp|Relative expression (normalized)" id="314" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Interstitial|Cyp|Relative expression (normalized)" id="315" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|Cyp|Relative expression (normalized)" id="316" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Plasma|Cyp|Relative expression (normalized)" id="317" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|BloodCells|Cyp|Relative expression (normalized)" id="318" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Interstitial|Cyp|Relative expression (normalized)" id="319" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|Cyp|Relative expression (normalized)" id="320" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Plasma|Cyp|Relative expression (normalized)" id="321" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|BloodCells|Cyp|Relative expression (normalized)" id="322" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Interstitial|Cyp|Relative expression (normalized)" id="323" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|Cyp|Relative expression (normalized)" id="324" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Plasma|Cyp|Relative expression (normalized)" id="325" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|BloodCells|Cyp|Relative expression (normalized)" id="326" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Interstitial|Cyp|Relative expression (normalized)" id="327" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|Cyp|Relative expression (normalized)" id="328" />
-          <Map s="Organism|LargeIntestine|Plasma|Cyp|Relative expression (normalized)" id="329" />
-          <Map s="Organism|LargeIntestine|BloodCells|Cyp|Relative expression (normalized)" id="330" />
-          <Map s="Organism|LargeIntestine|Interstitial|Cyp|Relative expression (normalized)" id="331" />
-          <Map s="Organism|LargeIntestine|Intracellular|Cyp|Relative expression (normalized)" id="332" />
-          <Map s="Organism|LargeIntestine|Mucosa|Caecum|Plasma|Cyp|Relative expression (normalized)" id="333" />
-          <Map s="Organism|LargeIntestine|Mucosa|Caecum|BloodCells|Cyp|Relative expression (normalized)" id="334" />
-          <Map s="Organism|LargeIntestine|Mucosa|Caecum|Interstitial|Cyp|Relative expression (normalized)" id="335" />
-          <Map s="Organism|LargeIntestine|Mucosa|Caecum|Intracellular|Cyp|Relative expression (normalized)" id="336" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonAscendens|Plasma|Cyp|Relative expression (normalized)" id="337" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonAscendens|BloodCells|Cyp|Relative expression (normalized)" id="338" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonAscendens|Interstitial|Cyp|Relative expression (normalized)" id="339" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|Cyp|Relative expression (normalized)" id="340" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonTransversum|Plasma|Cyp|Relative expression (normalized)" id="341" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonTransversum|BloodCells|Cyp|Relative expression (normalized)" id="342" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonTransversum|Interstitial|Cyp|Relative expression (normalized)" id="343" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|Cyp|Relative expression (normalized)" id="344" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonDescendens|Plasma|Cyp|Relative expression (normalized)" id="345" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonDescendens|BloodCells|Cyp|Relative expression (normalized)" id="346" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonDescendens|Interstitial|Cyp|Relative expression (normalized)" id="347" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|Cyp|Relative expression (normalized)" id="348" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonSigmoid|Plasma|Cyp|Relative expression (normalized)" id="349" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonSigmoid|BloodCells|Cyp|Relative expression (normalized)" id="350" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonSigmoid|Interstitial|Cyp|Relative expression (normalized)" id="351" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|Cyp|Relative expression (normalized)" id="352" />
-          <Map s="Organism|LargeIntestine|Mucosa|Rectum|Plasma|Cyp|Relative expression (normalized)" id="353" />
-          <Map s="Organism|LargeIntestine|Mucosa|Rectum|BloodCells|Cyp|Relative expression (normalized)" id="354" />
-          <Map s="Organism|LargeIntestine|Mucosa|Rectum|Interstitial|Cyp|Relative expression (normalized)" id="355" />
-          <Map s="Organism|LargeIntestine|Mucosa|Rectum|Intracellular|Cyp|Relative expression (normalized)" id="356" />
-          <Map s="Organism|Liver|Plasma|Cyp|Relative expression (normalized)" id="357" />
-          <Map s="Organism|Liver|BloodCells|Cyp|Relative expression (normalized)" id="358" />
-          <Map s="Organism|Liver|Interstitial|Cyp|Relative expression (normalized)" id="359" />
-          <Map s="Organism|Liver|Intracellular|Cyp|Relative expression (normalized)" id="360" />
-          <Map s="Organism|Lung|Plasma|Cyp|Relative expression (normalized)" id="361" />
-          <Map s="Organism|Lung|BloodCells|Cyp|Relative expression (normalized)" id="362" />
-          <Map s="Organism|Lung|Interstitial|Cyp|Relative expression (normalized)" id="363" />
-          <Map s="Organism|Lung|Intracellular|Cyp|Relative expression (normalized)" id="364" />
-          <Map s="Organism|Muscle|Plasma|Cyp|Relative expression (normalized)" id="365" />
-          <Map s="Organism|Muscle|BloodCells|Cyp|Relative expression (normalized)" id="366" />
-          <Map s="Organism|Muscle|Interstitial|Cyp|Relative expression (normalized)" id="367" />
-          <Map s="Organism|Muscle|Intracellular|Cyp|Relative expression (normalized)" id="368" />
-          <Map s="Organism|Pancreas|Plasma|Cyp|Relative expression (normalized)" id="369" />
-          <Map s="Organism|Pancreas|BloodCells|Cyp|Relative expression (normalized)" id="370" />
-          <Map s="Organism|Pancreas|Interstitial|Cyp|Relative expression (normalized)" id="371" />
-          <Map s="Organism|Pancreas|Intracellular|Cyp|Relative expression (normalized)" id="372" />
-          <Map s="Organism|PortalVein|Plasma|Cyp|Relative expression (normalized)" id="373" />
-          <Map s="Organism|PortalVein|BloodCells|Cyp|Relative expression (normalized)" id="374" />
-          <Map s="Organism|Skin|Plasma|Cyp|Relative expression (normalized)" id="375" />
-          <Map s="Organism|Skin|BloodCells|Cyp|Relative expression (normalized)" id="376" />
-          <Map s="Organism|Skin|Interstitial|Cyp|Relative expression (normalized)" id="377" />
-          <Map s="Organism|Skin|Intracellular|Cyp|Relative expression (normalized)" id="378" />
-          <Map s="Organism|Spleen|Plasma|Cyp|Relative expression (normalized)" id="379" />
-          <Map s="Organism|Spleen|BloodCells|Cyp|Relative expression (normalized)" id="380" />
-          <Map s="Organism|Spleen|Interstitial|Cyp|Relative expression (normalized)" id="381" />
-          <Map s="Organism|Spleen|Intracellular|Cyp|Relative expression (normalized)" id="382" />
-          <Map s="Organism|Saliva|Saliva|Cyp|Relative expression (normalized)" id="383" />
-          <Map s="Organism|Saliva|SalivaGland|Cyp|Relative expression (normalized)" id="384" />
-          <Map s="Organism|Gallbladder|Cyp|Relative expression" id="385" />
-          <Map s="Organism|VenousBlood|Plasma|Cyp|Relative expression" id="386" />
-          <Map s="Organism|VenousBlood|BloodCells|Cyp|Relative expression" id="387" />
-          <Map s="Organism|ArterialBlood|Plasma|Cyp|Relative expression" id="388" />
-          <Map s="Organism|ArterialBlood|BloodCells|Cyp|Relative expression" id="389" />
-          <Map s="Organism|Bone|Plasma|Cyp|Relative expression" id="390" />
-          <Map s="Organism|Bone|BloodCells|Cyp|Relative expression" id="391" />
-          <Map s="Organism|Bone|Interstitial|Cyp|Relative expression" id="392" />
-          <Map s="Organism|Bone|Intracellular|Cyp|Relative expression" id="393" />
-          <Map s="Organism|Brain|Plasma|Cyp|Relative expression" id="394" />
-          <Map s="Organism|Brain|BloodCells|Cyp|Relative expression" id="395" />
-          <Map s="Organism|Brain|Interstitial|Cyp|Relative expression" id="396" />
-          <Map s="Organism|Brain|Intracellular|Cyp|Relative expression" id="397" />
-          <Map s="Organism|Fat|Plasma|Cyp|Relative expression" id="398" />
-          <Map s="Organism|Fat|BloodCells|Cyp|Relative expression" id="399" />
-          <Map s="Organism|Fat|Interstitial|Cyp|Relative expression" id="400" />
-          <Map s="Organism|Fat|Intracellular|Cyp|Relative expression" id="401" />
-          <Map s="Organism|Gonads|Plasma|Cyp|Relative expression" id="402" />
-          <Map s="Organism|Gonads|BloodCells|Cyp|Relative expression" id="403" />
-          <Map s="Organism|Gonads|Interstitial|Cyp|Relative expression" id="404" />
-          <Map s="Organism|Gonads|Intracellular|Cyp|Relative expression" id="405" />
-          <Map s="Organism|Heart|Plasma|Cyp|Relative expression" id="406" />
-          <Map s="Organism|Heart|BloodCells|Cyp|Relative expression" id="407" />
-          <Map s="Organism|Heart|Interstitial|Cyp|Relative expression" id="408" />
-          <Map s="Organism|Heart|Intracellular|Cyp|Relative expression" id="409" />
-          <Map s="Organism|Kidney|Plasma|Cyp|Relative expression" id="410" />
-          <Map s="Organism|Kidney|BloodCells|Cyp|Relative expression" id="411" />
-          <Map s="Organism|Kidney|Interstitial|Cyp|Relative expression" id="412" />
-          <Map s="Organism|Kidney|Intracellular|Cyp|Relative expression" id="413" />
-          <Map s="Organism|Kidney|Urine|Cyp|Relative expression" id="414" />
-          <Map s="Organism|Lumen|Stomach|Cyp|Relative expression" id="415" />
-          <Map s="Organism|Lumen|Duodenum|Cyp|Relative expression" id="416" />
-          <Map s="Organism|Lumen|UpperJejunum|Cyp|Relative expression" id="417" />
-          <Map s="Organism|Lumen|LowerJejunum|Cyp|Relative expression" id="418" />
-          <Map s="Organism|Lumen|UpperIleum|Cyp|Relative expression" id="419" />
-          <Map s="Organism|Lumen|LowerIleum|Cyp|Relative expression" id="420" />
-          <Map s="Organism|Lumen|Caecum|Cyp|Relative expression" id="421" />
-          <Map s="Organism|Lumen|ColonAscendens|Cyp|Relative expression" id="422" />
-          <Map s="Organism|Lumen|ColonTransversum|Cyp|Relative expression" id="423" />
-          <Map s="Organism|Lumen|ColonDescendens|Cyp|Relative expression" id="424" />
-          <Map s="Organism|Lumen|ColonSigmoid|Cyp|Relative expression" id="425" />
-          <Map s="Organism|Lumen|Rectum|Cyp|Relative expression" id="426" />
-          <Map s="Organism|Lumen|Feces|Cyp|Relative expression" id="427" />
-          <Map s="Organism|Stomach|Plasma|Cyp|Relative expression" id="428" />
-          <Map s="Organism|Stomach|BloodCells|Cyp|Relative expression" id="429" />
-          <Map s="Organism|Stomach|Interstitial|Cyp|Relative expression" id="430" />
-          <Map s="Organism|Stomach|Intracellular|Cyp|Relative expression" id="431" />
-          <Map s="Organism|SmallIntestine|Plasma|Cyp|Relative expression" id="432" />
-          <Map s="Organism|SmallIntestine|BloodCells|Cyp|Relative expression" id="433" />
-          <Map s="Organism|SmallIntestine|Interstitial|Cyp|Relative expression" id="434" />
-          <Map s="Organism|SmallIntestine|Intracellular|Cyp|Relative expression" id="435" />
-          <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Plasma|Cyp|Relative expression" id="436" />
-          <Map s="Organism|SmallIntestine|Mucosa|Duodenum|BloodCells|Cyp|Relative expression" id="437" />
-          <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Interstitial|Cyp|Relative expression" id="438" />
-          <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|Cyp|Relative expression" id="439" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Plasma|Cyp|Relative expression" id="440" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|BloodCells|Cyp|Relative expression" id="441" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Interstitial|Cyp|Relative expression" id="442" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|Cyp|Relative expression" id="443" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Plasma|Cyp|Relative expression" id="444" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|BloodCells|Cyp|Relative expression" id="445" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Interstitial|Cyp|Relative expression" id="446" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|Cyp|Relative expression" id="447" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Plasma|Cyp|Relative expression" id="448" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|BloodCells|Cyp|Relative expression" id="449" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Interstitial|Cyp|Relative expression" id="450" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|Cyp|Relative expression" id="451" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Plasma|Cyp|Relative expression" id="452" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|BloodCells|Cyp|Relative expression" id="453" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Interstitial|Cyp|Relative expression" id="454" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|Cyp|Relative expression" id="455" />
-          <Map s="Organism|LargeIntestine|Plasma|Cyp|Relative expression" id="456" />
-          <Map s="Organism|LargeIntestine|BloodCells|Cyp|Relative expression" id="457" />
-          <Map s="Organism|LargeIntestine|Interstitial|Cyp|Relative expression" id="458" />
-          <Map s="Organism|LargeIntestine|Intracellular|Cyp|Relative expression" id="459" />
-          <Map s="Organism|LargeIntestine|Mucosa|Caecum|Plasma|Cyp|Relative expression" id="460" />
-          <Map s="Organism|LargeIntestine|Mucosa|Caecum|BloodCells|Cyp|Relative expression" id="461" />
-          <Map s="Organism|LargeIntestine|Mucosa|Caecum|Interstitial|Cyp|Relative expression" id="462" />
-          <Map s="Organism|LargeIntestine|Mucosa|Caecum|Intracellular|Cyp|Relative expression" id="463" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonAscendens|Plasma|Cyp|Relative expression" id="464" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonAscendens|BloodCells|Cyp|Relative expression" id="465" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonAscendens|Interstitial|Cyp|Relative expression" id="466" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|Cyp|Relative expression" id="467" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonTransversum|Plasma|Cyp|Relative expression" id="468" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonTransversum|BloodCells|Cyp|Relative expression" id="469" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonTransversum|Interstitial|Cyp|Relative expression" id="470" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|Cyp|Relative expression" id="471" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonDescendens|Plasma|Cyp|Relative expression" id="472" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonDescendens|BloodCells|Cyp|Relative expression" id="473" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonDescendens|Interstitial|Cyp|Relative expression" id="474" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|Cyp|Relative expression" id="475" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonSigmoid|Plasma|Cyp|Relative expression" id="476" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonSigmoid|BloodCells|Cyp|Relative expression" id="477" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonSigmoid|Interstitial|Cyp|Relative expression" id="478" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|Cyp|Relative expression" id="479" />
-          <Map s="Organism|LargeIntestine|Mucosa|Rectum|Plasma|Cyp|Relative expression" id="480" />
-          <Map s="Organism|LargeIntestine|Mucosa|Rectum|BloodCells|Cyp|Relative expression" id="481" />
-          <Map s="Organism|LargeIntestine|Mucosa|Rectum|Interstitial|Cyp|Relative expression" id="482" />
-          <Map s="Organism|LargeIntestine|Mucosa|Rectum|Intracellular|Cyp|Relative expression" id="483" />
-          <Map s="Organism|Liver|Plasma|Cyp|Relative expression" id="484" />
-          <Map s="Organism|Liver|BloodCells|Cyp|Relative expression" id="485" />
-          <Map s="Organism|Liver|Interstitial|Cyp|Relative expression" id="486" />
-          <Map s="Organism|Liver|Intracellular|Cyp|Relative expression" id="487" />
-          <Map s="Organism|Lung|Plasma|Cyp|Relative expression" id="488" />
-          <Map s="Organism|Lung|BloodCells|Cyp|Relative expression" id="489" />
-          <Map s="Organism|Lung|Interstitial|Cyp|Relative expression" id="490" />
-          <Map s="Organism|Lung|Intracellular|Cyp|Relative expression" id="491" />
-          <Map s="Organism|Muscle|Plasma|Cyp|Relative expression" id="492" />
-          <Map s="Organism|Muscle|BloodCells|Cyp|Relative expression" id="493" />
-          <Map s="Organism|Muscle|Interstitial|Cyp|Relative expression" id="494" />
-          <Map s="Organism|Muscle|Intracellular|Cyp|Relative expression" id="495" />
-          <Map s="Organism|Pancreas|Plasma|Cyp|Relative expression" id="496" />
-          <Map s="Organism|Pancreas|BloodCells|Cyp|Relative expression" id="497" />
-          <Map s="Organism|Pancreas|Interstitial|Cyp|Relative expression" id="498" />
-          <Map s="Organism|Pancreas|Intracellular|Cyp|Relative expression" id="499" />
-          <Map s="Organism|PortalVein|Plasma|Cyp|Relative expression" id="500" />
-          <Map s="Organism|PortalVein|BloodCells|Cyp|Relative expression" id="501" />
-          <Map s="Organism|Skin|Plasma|Cyp|Relative expression" id="502" />
-          <Map s="Organism|Skin|BloodCells|Cyp|Relative expression" id="503" />
-          <Map s="Organism|Skin|Interstitial|Cyp|Relative expression" id="504" />
-          <Map s="Organism|Skin|Intracellular|Cyp|Relative expression" id="505" />
-          <Map s="Organism|Spleen|Plasma|Cyp|Relative expression" id="506" />
-          <Map s="Organism|Spleen|BloodCells|Cyp|Relative expression" id="507" />
-          <Map s="Organism|Spleen|Interstitial|Cyp|Relative expression" id="508" />
-          <Map s="Organism|Spleen|Intracellular|Cyp|Relative expression" id="509" />
-          <Map s="Organism|Saliva|Saliva|Cyp|Relative expression" id="510" />
-          <Map s="Organism|Saliva|SalivaGland|Cyp|Relative expression" id="511" />
-          <Map s="Cyp|Rel. exp. variability factor" id="512" />
-          <Map s="Cyp|Reference concentration" id="513" />
-          <Map s="Cyp|Relative expression in vascular endothelium (normalized)" id="514" />
-          <Map s="Cyp|Relative expression in blood cells (normalized)" id="515" />
-          <Map s="Organism|Surface area scaling exponent" id="516" />
-          <Map s="Organism|SA proportionality factor" id="517" />
-          <Map s="Organism|Vf (lipid, blood cells)" id="518" />
-          <Map s="Organism|Vf (water,blood cells)" id="519" />
-          <Map s="Organism|FcRn receptor conc. (endosome)" id="520" />
-          <Map s="Organism|Vf (water,interstitial)" id="521" />
-          <Map s="Organism|Protein ratio (interstial/plasma)" id="522" />
-          <Map s="Organism|Vf (protein,plasma)" id="523" />
-          <Map s="Organism|Vf (protein,blood cells)" id="524" />
-          <Map s="Organism|Vf (neutral lipid, plasma)-RR" id="525" />
-          <Map s="Organism|Vf (neutral lipid, blood cells)-WS" id="526" />
-          <Map s="Organism|Vf (lipid, plasma)" id="527" />
-          <Map s="Organism|Vf (water,plasma)" id="528" />
-          <Map s="Organism|Na" id="529" />
-          <Map s="Organism|R*T" id="530" />
-          <Map s="Organism|Age" id="531" />
-          <Map s="Organism|Rate constant for recycling from endosomal space (global)" id="532" />
-          <Map s="Organism|Rate constant for endosomal uptake (global)" id="533" />
-          <Map s="Organism|Fraction recycled to plasma (global)" id="534" />
-          <Map s="Organism|Fraction of endosomal uptake from plasma (global)" id="535" />
-          <Map s="Organism|Surface/Volume ratio (blood cells)" id="536" />
-          <Map s="Organism|pH (blood cells)" id="537" />
-          <Map s="Organism|pH (interstitial)" id="538" />
-          <Map s="Organism|pH (intracellular)" id="539" />
-          <Map s="Organism|pH (plasma)" id="540" />
-          <Map s="Organism|Thickness (endothelium)" id="541" />
-          <Map s="Organism|Height" id="542" />
-          <Map s="Organism|Fraction endosomal (global)" id="543" />
-          <Map s="Organism|Vf (neutral phospholipid, blood cells)-WS" id="544" />
-          <Map s="Organism|Vf (neutral lipid, plasma)-PT" id="545" />
-          <Map s="Organism|Vf (neutral phospholipid, plasma)-RR" id="546" />
-          <Map s="Organism|Vf (acidic phospholipids, blood cells)-WS" id="547" />
-          <Map s="Organism|Vf (phospholipid, plasma)-PT" id="548" />
-          <Map s="Organism|Vf (neutral lipid, blood cells)-RR" id="549" />
-          <Map s="Organism|Vf (neutral phospholipid, blood cells)-RR" id="550" />
-          <Map s="Organism|Vf (water,plasma)-PT" id="551" />
-          <Map s="Organism|Acidic phospholipids (blood cells) [mg/g] - RR" id="552" />
-          <Map s="Organism|Vf (intracellular water, blood cells)-RR" id="553" />
-          <Map s="Organism|MeanBW|Percentile" id="554" />
-          <Map s="Organism|MeanBW|Mean" id="555" />
-          <Map s="Organism|MeanBW|Deviation" id="556" />
-          <Map s="Organism|MeanHeight|Percentile" id="557" />
-          <Map s="Organism|MeanHeight|Mean" id="558" />
-          <Map s="Organism|MeanHeight|Deviation" id="559" />
-          <Map s="Organism|Hematocrit|Percentile" id="560" />
-          <Map s="Organism|Hematocrit|Mean" id="561" />
-          <Map s="Organism|PeripheralVenousBlood|Density (tissue)" id="562" />
-          <Map s="Organism|VenousBlood|Allometric scale factor" id="563" />
-          <Map s="Organism|VenousBlood|Density (tissue)" id="564" />
-          <Map s="Organism|VenousBlood|Fraction vascular" id="565" />
-          <Map s="Organism|VenousBlood|Volume|Percentile" id="566" />
-          <Map s="Organism|VenousBlood|Volume|Mean" id="567" />
-          <Map s="Organism|VenousBlood|Volume|Deviation" id="568" />
-          <Map s="Organism|ArterialBlood|Allometric scale factor" id="569" />
-          <Map s="Organism|ArterialBlood|Density (tissue)" id="570" />
-          <Map s="Organism|ArterialBlood|Peripheral blood flow fraction" id="571" />
-          <Map s="Organism|ArterialBlood|Fraction vascular" id="572" />
-          <Map s="Organism|ArterialBlood|Volume|Percentile" id="573" />
-          <Map s="Organism|ArterialBlood|Volume|Mean" id="574" />
-          <Map s="Organism|ArterialBlood|Volume|Deviation" id="575" />
-          <Map s="Organism|Gallbladder|Volume" id="576" />
-          <Map s="Organism|Gallbladder|Gallbladder emptying rate" id="577" />
-          <Map s="Organism|Gallbladder|Gallbladder ejection half-time" id="578" />
-          <Map s="Organism|Gallbladder|Gallbladder ejection fraction" id="579" />
-          <Map s="Organism|Bone|Allometric scale factor" id="580" />
-          <Map s="Organism|Bone|Density (tissue)" id="581" />
-          <Map s="Organism|Bone|Peripheral blood flow fraction" id="582" />
-          <Map s="Organism|Bone|Fraction of blood for sampling" id="583" />
-          <Map s="Organism|Bone|Fluid recirculation flow rate" id="584" />
-          <Map s="Organism|Bone|Flow fraction via large pores" id="585" />
-          <Map s="Organism|Bone|Radius (small pores)" id="586" />
-          <Map s="Organism|Bone|Radius (large pores)" id="587" />
-          <Map s="Organism|Bone|Lymph flow rate" id="588" />
-          <Map s="Organism|Bone|Hydraulic conductivity" id="589" />
-          <Map s="Organism|Bone|Vf (neutral lipid)-PT" id="590" />
-          <Map s="Organism|Bone|Vf (lipid)" id="591" />
-          <Map s="Organism|Bone|Fraction vascular" id="592" />
-          <Map s="Organism|Bone|Vf (protein)" id="593" />
-          <Map s="Organism|Bone|Vf (phospholipid)-PT" id="594" />
-          <Map s="Organism|Bone|Albumin ratio (tissue/plasma)" id="595" />
-          <Map s="Organism|Bone|Lipoprotein ratio (tissue/plasma)" id="596" />
-          <Map s="Organism|Bone|Albumin ratio (tissue/plasma)-PT" id="597" />
-          <Map s="Organism|Bone|Vf (water)" id="598" />
-          <Map s="Organism|Bone|Vf (water)-PT" id="599" />
-          <Map s="Organism|Bone|Microsomal protein mass/g tissue" id="600" />
-          <Map s="Organism|Bone|Number of cells/g tissue" id="601" />
-          <Map s="Organism|Bone|Protein mass/g tissue" id="602" />
-          <Map s="Organism|Bone|Fraction interstitial" id="603" />
-          <Map s="Organism|Bone|Vf (neutral lipid)-RR" id="604" />
-          <Map s="Organism|Bone|Vf (neutral lipid)-WS" id="605" />
-          <Map s="Organism|Bone|Vf (neutral phospholipid, plasma)-WS" id="606" />
-          <Map s="Organism|Bone|Vf (neutral phospholipid)-RR" id="607" />
-          <Map s="Organism|Bone|Vf (extracellular water)-RR" id="608" />
-          <Map s="Organism|Bone|Vf (protein)-WS" id="609" />
-          <Map s="Organism|Bone|Vf (water)-WS" id="610" />
-          <Map s="Organism|Bone|Vf (intracellular water)-RR" id="611" />
-          <Map s="Organism|Bone|Vf (acidic phospholipids)-WS" id="612" />
-          <Map s="Organism|Bone|Acidic phospholipids [mg/g] - RR" id="613" />
-          <Map s="Organism|Bone|Specific blood flow rate|Percentile" id="614" />
-          <Map s="Organism|Bone|Specific blood flow rate|Mean" id="615" />
-          <Map s="Organism|Bone|Specific blood flow rate|Deviation" id="616" />
-          <Map s="Organism|Bone|Volume|Percentile" id="617" />
-          <Map s="Organism|Bone|Volume|Mean" id="618" />
-          <Map s="Organism|Bone|Volume|Deviation" id="619" />
-          <Map s="Organism|Bone|Intracellular|pH" id="620" />
-          <Map s="Organism|Brain|Allometric scale factor" id="621" />
-          <Map s="Organism|Brain|Density (tissue)" id="622" />
-          <Map s="Organism|Brain|Fraction of blood for sampling" id="623" />
-          <Map s="Organism|Brain|Fluid recirculation flow rate" id="624" />
-          <Map s="Organism|Brain|Flow fraction via large pores" id="625" />
-          <Map s="Organism|Brain|Hydraulic conductivity" id="626" />
-          <Map s="Organism|Brain|Radius (large pores)" id="627" />
-          <Map s="Organism|Brain|Radius (small pores)" id="628" />
-          <Map s="Organism|Brain|Lymph flow rate" id="629" />
-          <Map s="Organism|Brain|Vf (neutral lipid)-PT" id="630" />
-          <Map s="Organism|Brain|Vf (lipid)" id="631" />
-          <Map s="Organism|Brain|Fraction vascular" id="632" />
-          <Map s="Organism|Brain|Vf (phospholipid)-PT" id="633" />
-          <Map s="Organism|Brain|Vf (protein)" id="634" />
-          <Map s="Organism|Brain|Albumin ratio (tissue/plasma)-PT" id="635" />
-          <Map s="Organism|Brain|Vf (water)" id="636" />
-          <Map s="Organism|Brain|Lipoprotein ratio (tissue/plasma)" id="637" />
-          <Map s="Organism|Brain|Vf (water)-PT" id="638" />
-          <Map s="Organism|Brain|Albumin ratio (tissue/plasma)" id="639" />
-          <Map s="Organism|Brain|Number of cells/g tissue" id="640" />
-          <Map s="Organism|Brain|Microsomal protein mass/g tissue" id="641" />
-          <Map s="Organism|Brain|Protein mass/g tissue" id="642" />
-          <Map s="Organism|Brain|Fraction interstitial" id="643" />
-          <Map s="Organism|Brain|Vf (neutral lipid)-RR" id="644" />
-          <Map s="Organism|Brain|Vf (neutral lipid)-WS" id="645" />
-          <Map s="Organism|Brain|Vf (neutral phospholipid, plasma)-WS" id="646" />
-          <Map s="Organism|Brain|Vf (neutral phospholipid)-RR" id="647" />
-          <Map s="Organism|Brain|Vf (extracellular water)-RR" id="648" />
-          <Map s="Organism|Brain|Vf (protein)-WS" id="649" />
-          <Map s="Organism|Brain|Vf (intracellular water)-RR" id="650" />
-          <Map s="Organism|Brain|Vf (water)-WS" id="651" />
-          <Map s="Organism|Brain|Vf (acidic phospholipids)-WS" id="652" />
-          <Map s="Organism|Brain|Acidic phospholipids [mg/g] - RR" id="653" />
-          <Map s="Organism|Brain|Volume|Percentile" id="654" />
-          <Map s="Organism|Brain|Volume|Mean" id="655" />
-          <Map s="Organism|Brain|Volume|Deviation" id="656" />
-          <Map s="Organism|Brain|Specific blood flow rate|Percentile" id="657" />
-          <Map s="Organism|Brain|Specific blood flow rate|Mean" id="658" />
-          <Map s="Organism|Brain|Specific blood flow rate|Deviation" id="659" />
-          <Map s="Organism|Brain|Intracellular|pH" id="660" />
-          <Map s="Organism|Fat|Allometric scale factor" id="661" />
-          <Map s="Organism|Fat|Density (tissue)" id="662" />
-          <Map s="Organism|Fat|Peripheral blood flow fraction" id="663" />
-          <Map s="Organism|Fat|Fraction of blood for sampling" id="664" />
-          <Map s="Organism|Fat|Radius (large pores)" id="665" />
-          <Map s="Organism|Fat|Lymph flow rate" id="666" />
-          <Map s="Organism|Fat|Flow fraction via large pores" id="667" />
-          <Map s="Organism|Fat|Radius (small pores)" id="668" />
-          <Map s="Organism|Fat|Hydraulic conductivity" id="669" />
-          <Map s="Organism|Fat|Fluid recirculation flow rate" id="670" />
-          <Map s="Organism|Fat|Vf (neutral lipid)-PT" id="671" />
-          <Map s="Organism|Fat|Vf (lipid)" id="672" />
-          <Map s="Organism|Fat|Fraction vascular" id="673" />
-          <Map s="Organism|Fat|Vf (protein)" id="674" />
-          <Map s="Organism|Fat|Vf (phospholipid)-PT" id="675" />
-          <Map s="Organism|Fat|Vf (water)-PT" id="676" />
-          <Map s="Organism|Fat|Lipoprotein ratio (tissue/plasma)" id="677" />
-          <Map s="Organism|Fat|Vf (water)" id="678" />
-          <Map s="Organism|Fat|Albumin ratio (tissue/plasma)-PT" id="679" />
-          <Map s="Organism|Fat|Albumin ratio (tissue/plasma)" id="680" />
-          <Map s="Organism|Fat|Number of cells/g tissue" id="681" />
-          <Map s="Organism|Fat|Protein mass/g tissue" id="682" />
-          <Map s="Organism|Fat|Microsomal protein mass/g tissue" id="683" />
-          <Map s="Organism|Fat|Vf (neutral lipid)-WS" id="684" />
-          <Map s="Organism|Fat|Vf (neutral lipid)-RR" id="685" />
-          <Map s="Organism|Fat|Vf (neutral phospholipid, plasma)-WS" id="686" />
-          <Map s="Organism|Fat|Vf (neutral phospholipid)-RR" id="687" />
-          <Map s="Organism|Fat|Vf (protein)-WS" id="688" />
-          <Map s="Organism|Fat|Vf (extracellular water)-RR" id="689" />
-          <Map s="Organism|Fat|Vf (intracellular water)-RR" id="690" />
-          <Map s="Organism|Fat|Vf (water)-WS" id="691" />
-          <Map s="Organism|Fat|Vf (acidic phospholipids)-WS" id="692" />
-          <Map s="Organism|Fat|Acidic phospholipids [mg/g] - RR" id="693" />
-          <Map s="Organism|Fat|Volume fraction lipids scale factor|Percentile" id="694" />
-          <Map s="Organism|Fat|Volume fraction lipids scale factor|Mean" id="695" />
-          <Map s="Organism|Fat|Volume fraction water scale factor|Percentile" id="696" />
-          <Map s="Organism|Fat|Volume fraction water scale factor|Mean" id="697" />
-          <Map s="Organism|Fat|Volume|Percentile" id="698" />
-          <Map s="Organism|Fat|Volume|Mean" id="699" />
-          <Map s="Organism|Fat|Volume|GeometricDeviation" id="700" />
-          <Map s="Organism|Fat|Fraction interstitial|Percentile" id="701" />
-          <Map s="Organism|Fat|Fraction interstitial|Mean" id="702" />
-          <Map s="Organism|Fat|Specific blood flow rate|Percentile" id="703" />
-          <Map s="Organism|Fat|Specific blood flow rate|Mean" id="704" />
-          <Map s="Organism|Fat|Specific blood flow rate|Deviation" id="705" />
-          <Map s="Organism|Fat|Intracellular|pH" id="706" />
-          <Map s="Organism|Gonads|Allometric scale factor" id="707" />
-          <Map s="Organism|Gonads|Density (tissue)" id="708" />
-          <Map s="Organism|Gonads|Fraction of blood for sampling" id="709" />
-          <Map s="Organism|Gonads|Hydraulic conductivity" id="710" />
-          <Map s="Organism|Gonads|Fluid recirculation flow rate" id="711" />
-          <Map s="Organism|Gonads|Lymph flow rate" id="712" />
-          <Map s="Organism|Gonads|Flow fraction via large pores" id="713" />
-          <Map s="Organism|Gonads|Radius (large pores)" id="714" />
-          <Map s="Organism|Gonads|Radius (small pores)" id="715" />
-          <Map s="Organism|Gonads|Vf (lipid)" id="716" />
-          <Map s="Organism|Gonads|Vf (neutral lipid)-PT" id="717" />
-          <Map s="Organism|Gonads|Fraction vascular" id="718" />
-          <Map s="Organism|Gonads|Vf (protein)" id="719" />
-          <Map s="Organism|Gonads|Vf (phospholipid)-PT" id="720" />
-          <Map s="Organism|Gonads|Lipoprotein ratio (tissue/plasma)" id="721" />
-          <Map s="Organism|Gonads|Albumin ratio (tissue/plasma)" id="722" />
-          <Map s="Organism|Gonads|Albumin ratio (tissue/plasma)-PT" id="723" />
-          <Map s="Organism|Gonads|Vf (water)-PT" id="724" />
-          <Map s="Organism|Gonads|Vf (water)" id="725" />
-          <Map s="Organism|Gonads|Number of cells/g tissue" id="726" />
-          <Map s="Organism|Gonads|Protein mass/g tissue" id="727" />
-          <Map s="Organism|Gonads|Microsomal protein mass/g tissue" id="728" />
-          <Map s="Organism|Gonads|Fraction interstitial" id="729" />
-          <Map s="Organism|Gonads|Vf (neutral lipid)-WS" id="730" />
-          <Map s="Organism|Gonads|Vf (neutral lipid)-RR" id="731" />
-          <Map s="Organism|Gonads|Vf (neutral phospholipid)-RR" id="732" />
-          <Map s="Organism|Gonads|Vf (neutral phospholipid, plasma)-WS" id="733" />
-          <Map s="Organism|Gonads|Vf (protein)-WS" id="734" />
-          <Map s="Organism|Gonads|Vf (extracellular water)-RR" id="735" />
-          <Map s="Organism|Gonads|Vf (water)-WS" id="736" />
-          <Map s="Organism|Gonads|Vf (intracellular water)-RR" id="737" />
-          <Map s="Organism|Gonads|Acidic phospholipids [mg/g] - RR" id="738" />
-          <Map s="Organism|Gonads|Vf (acidic phospholipids)-WS" id="739" />
-          <Map s="Organism|Gonads|Volume|Percentile" id="740" />
-          <Map s="Organism|Gonads|Volume|Mean" id="741" />
-          <Map s="Organism|Gonads|Volume|Deviation" id="742" />
-          <Map s="Organism|Gonads|Specific blood flow rate|Percentile" id="743" />
-          <Map s="Organism|Gonads|Specific blood flow rate|Mean" id="744" />
-          <Map s="Organism|Gonads|Specific blood flow rate|Deviation" id="745" />
-          <Map s="Organism|Gonads|Intracellular|pH" id="746" />
-          <Map s="Organism|Heart|Allometric scale factor" id="747" />
-          <Map s="Organism|Heart|Density (tissue)" id="748" />
-          <Map s="Organism|Heart|Fraction of blood for sampling" id="749" />
-          <Map s="Organism|Heart|Radius (large pores)" id="750" />
-          <Map s="Organism|Heart|Fluid recirculation flow rate" id="751" />
-          <Map s="Organism|Heart|Flow fraction via large pores" id="752" />
-          <Map s="Organism|Heart|Lymph flow rate" id="753" />
-          <Map s="Organism|Heart|Hydraulic conductivity" id="754" />
-          <Map s="Organism|Heart|Radius (small pores)" id="755" />
-          <Map s="Organism|Heart|Vf (neutral lipid)-PT" id="756" />
-          <Map s="Organism|Heart|Vf (lipid)" id="757" />
-          <Map s="Organism|Heart|Fraction vascular" id="758" />
-          <Map s="Organism|Heart|Vf (phospholipid)-PT" id="759" />
-          <Map s="Organism|Heart|Vf (protein)" id="760" />
-          <Map s="Organism|Heart|Albumin ratio (tissue/plasma)" id="761" />
-          <Map s="Organism|Heart|Albumin ratio (tissue/plasma)-PT" id="762" />
-          <Map s="Organism|Heart|Vf (water)-PT" id="763" />
-          <Map s="Organism|Heart|Vf (water)" id="764" />
-          <Map s="Organism|Heart|Lipoprotein ratio (tissue/plasma)" id="765" />
-          <Map s="Organism|Heart|Microsomal protein mass/g tissue" id="766" />
-          <Map s="Organism|Heart|Protein mass/g tissue" id="767" />
-          <Map s="Organism|Heart|Number of cells/g tissue" id="768" />
-          <Map s="Organism|Heart|Fraction interstitial" id="769" />
-          <Map s="Organism|Heart|Vf (neutral lipid)-RR" id="770" />
-          <Map s="Organism|Heart|Vf (neutral lipid)-WS" id="771" />
-          <Map s="Organism|Heart|Vf (neutral phospholipid)-RR" id="772" />
-          <Map s="Organism|Heart|Vf (neutral phospholipid, plasma)-WS" id="773" />
-          <Map s="Organism|Heart|Vf (extracellular water)-RR" id="774" />
-          <Map s="Organism|Heart|Vf (protein)-WS" id="775" />
-          <Map s="Organism|Heart|Vf (water)-WS" id="776" />
-          <Map s="Organism|Heart|Vf (intracellular water)-RR" id="777" />
-          <Map s="Organism|Heart|Acidic phospholipids [mg/g] - RR" id="778" />
-          <Map s="Organism|Heart|Vf (acidic phospholipids)-WS" id="779" />
-          <Map s="Organism|Heart|Volume|Percentile" id="780" />
-          <Map s="Organism|Heart|Volume|Mean" id="781" />
-          <Map s="Organism|Heart|Volume|Deviation" id="782" />
-          <Map s="Organism|Heart|Specific blood flow rate|Percentile" id="783" />
-          <Map s="Organism|Heart|Specific blood flow rate|Mean" id="784" />
-          <Map s="Organism|Heart|Specific blood flow rate|Deviation" id="785" />
-          <Map s="Organism|Heart|Intracellular|pH" id="786" />
-          <Map s="Organism|Kidney|Allometric scale factor" id="787" />
-          <Map s="Organism|Kidney|Volume (standard kidney)" id="788" />
-          <Map s="Organism|Kidney|Density (tissue)" id="789" />
-          <Map s="Organism|Kidney|Fraction of blood for sampling" id="790" />
-          <Map s="Organism|Kidney|Lymph flow rate" id="791" />
-          <Map s="Organism|Kidney|Hydraulic conductivity" id="792" />
-          <Map s="Organism|Kidney|Flow fraction via large pores" id="793" />
-          <Map s="Organism|Kidney|Fluid recirculation flow rate" id="794" />
-          <Map s="Organism|Kidney|Radius (small pores)" id="795" />
-          <Map s="Organism|Kidney|Radius (large pores)" id="796" />
-          <Map s="Organism|Kidney|Vf (neutral lipid)-PT" id="797" />
-          <Map s="Organism|Kidney|Vf (lipid)" id="798" />
-          <Map s="Organism|Kidney|Fraction vascular" id="799" />
-          <Map s="Organism|Kidney|Vf (protein)" id="800" />
-          <Map s="Organism|Kidney|Vf (phospholipid)-PT" id="801" />
-          <Map s="Organism|Kidney|Vf (water)" id="802" />
-          <Map s="Organism|Kidney|Lipoprotein ratio (tissue/plasma)" id="803" />
-          <Map s="Organism|Kidney|Vf (water)-PT" id="804" />
-          <Map s="Organism|Kidney|Albumin ratio (tissue/plasma)-PT" id="805" />
-          <Map s="Organism|Kidney|Albumin ratio (tissue/plasma)" id="806" />
-          <Map s="Organism|Kidney|Number of cells/g tissue" id="807" />
-          <Map s="Organism|Kidney|Protein mass/g tissue" id="808" />
-          <Map s="Organism|Kidney|Microsomal protein mass/g tissue" id="809" />
-          <Map s="Organism|Kidney|Fraction interstitial" id="810" />
-          <Map s="Organism|Kidney|Vf (neutral lipid)-RR" id="811" />
-          <Map s="Organism|Kidney|Vf (neutral lipid)-WS" id="812" />
-          <Map s="Organism|Kidney|Vf (neutral phospholipid, plasma)-WS" id="813" />
-          <Map s="Organism|Kidney|Vf (neutral phospholipid)-RR" id="814" />
-          <Map s="Organism|Kidney|Vf (extracellular water)-RR" id="815" />
-          <Map s="Organism|Kidney|Vf (protein)-WS" id="816" />
-          <Map s="Organism|Kidney|Vf (intracellular water)-RR" id="817" />
-          <Map s="Organism|Kidney|Vf (water)-WS" id="818" />
-          <Map s="Organism|Kidney|Acidic phospholipids [mg/g] - RR" id="819" />
-          <Map s="Organism|Kidney|Vf (acidic phospholipids)-WS" id="820" />
-          <Map s="Organism|Kidney|fGFRpremat" id="821" />
-          <Map s="Organism|Kidney|Volume|Percentile" id="822" />
-          <Map s="Organism|Kidney|Volume|Mean" id="823" />
-          <Map s="Organism|Kidney|Volume|Deviation" id="824" />
-          <Map s="Organism|Kidney|TM50 for GFR|Percentile" id="825" />
-          <Map s="Organism|Kidney|TM50 for GFR|Mean" id="826" />
-          <Map s="Organism|Kidney|TM50 for GFR|Deviation" id="827" />
-          <Map s="Organism|Kidney|Hill coefficient for GFR|Percentile" id="828" />
-          <Map s="Organism|Kidney|Hill coefficient for GFR|Mean" id="829" />
-          <Map s="Organism|Kidney|Hill coefficient for GFR|Deviation" id="830" />
-          <Map s="Organism|Kidney|GFRmat|Percentile" id="831" />
-          <Map s="Organism|Kidney|GFRmat|Mean" id="832" />
-          <Map s="Organism|Kidney|GFRmat|Deviation" id="833" />
-          <Map s="Organism|Kidney|Specific blood flow rate|Percentile" id="834" />
-          <Map s="Organism|Kidney|Specific blood flow rate|Mean" id="835" />
-          <Map s="Organism|Kidney|Specific blood flow rate|Deviation" id="836" />
-          <Map s="Organism|Kidney|Intracellular|pH" id="837" />
-          <Map s="Organism|Kidney|Urine|Volume" id="838" />
-          <Map s="Organism|Lumen|OralApplicationsEnabled" id="839" />
-          <Map s="Organism|Lumen|Paracellular absorption sink condition" id="840" />
-          <Map s="Organism|Lumen|Transcellular absorption sink condition" id="841" />
-          <Map s="Organism|Lumen|Stomach|GET of non-disintegrated moiety" id="842" />
-          <Map s="Organism|Lumen|Stomach|Absorption of liquid" id="843" />
-          <Map s="Organism|Lumen|Stomach|pH in fasted state" id="844" />
-          <Map s="Organism|Lumen|Stomach|Inverse rate of inflow of liquid into stomach" id="845" />
-          <Map s="Organism|Lumen|Stomach|Gastric emptying time" id="846" />
-          <Map s="Organism|Lumen|Stomach|pH in fed state" id="847" />
-          <Map s="Organism|Lumen|Stomach|Fractional steady state fill level" id="848" />
-          <Map s="Organism|Lumen|Stomach|Thickness of gut wall" id="849" />
-          <Map s="Organism|Lumen|Stomach|Distal radius|Percentile" id="850" />
-          <Map s="Organism|Lumen|Stomach|Distal radius|Mean" id="851" />
-          <Map s="Organism|Lumen|Stomach|Proximal radius|Percentile" id="852" />
-          <Map s="Organism|Lumen|Stomach|Proximal radius|Mean" id="853" />
-          <Map s="Organism|Lumen|Stomach|Length|Percentile" id="854" />
-          <Map s="Organism|Lumen|Stomach|Length|Mean" id="855" />
-          <Map s="Organism|Lumen|Stomach|MoleculeProperties|Partition coefficient (water/container)" id="856" />
-          <Map s="Organism|Lumen|Duodenum|pH" id="857" />
-          <Map s="Organism|Lumen|Duodenum|Effective surface area enhancement factor" id="858" />
-          <Map s="Organism|Lumen|Duodenum|Fractional steady state fill level" id="859" />
-          <Map s="Organism|Lumen|Duodenum|r2_p0" id="860" />
-          <Map s="Organism|Lumen|Duodenum|Thickness_p3" id="861" />
-          <Map s="Organism|Lumen|Duodenum|Thickness_p2" id="862" />
-          <Map s="Organism|Lumen|Duodenum|r2_p1" id="863" />
-          <Map s="Organism|Lumen|Duodenum|r1_p1" id="864" />
-          <Map s="Organism|Lumen|Duodenum|r1_p0" id="865" />
-          <Map s="Organism|Lumen|Duodenum|Microvilli factor" id="866" />
-          <Map s="Organism|Lumen|Duodenum|L_p1" id="867" />
-          <Map s="Organism|Lumen|Duodenum|L_p0" id="868" />
-          <Map s="Organism|Lumen|Duodenum|Intestinal transit rate" id="869" />
-          <Map s="Organism|Lumen|Duodenum|Thickness_p1" id="870" />
-          <Map s="Organism|Lumen|Duodenum|MoleculeProperties|Partition coefficient (water/container)" id="871" />
-          <Map s="Organism|Lumen|Duodenum|MoleculeProperties|Oral mass absorbed segment" id="872" />
-          <Map s="Organism|Lumen|UpperJejunum|pH" id="873" />
-          <Map s="Organism|Lumen|UpperJejunum|L_p0" id="874" />
-          <Map s="Organism|Lumen|UpperJejunum|Fractional steady state fill level" id="875" />
-          <Map s="Organism|Lumen|UpperJejunum|Effective surface area enhancement factor" id="876" />
-          <Map s="Organism|Lumen|UpperJejunum|L_p1" id="877" />
-          <Map s="Organism|Lumen|UpperJejunum|Intestinal transit rate" id="878" />
-          <Map s="Organism|Lumen|UpperJejunum|Thickness_p2" id="879" />
-          <Map s="Organism|Lumen|UpperJejunum|Thickness_p3" id="880" />
-          <Map s="Organism|Lumen|UpperJejunum|Thickness_p1" id="881" />
-          <Map s="Organism|Lumen|UpperJejunum|r2_p1" id="882" />
-          <Map s="Organism|Lumen|UpperJejunum|r2_p0" id="883" />
-          <Map s="Organism|Lumen|UpperJejunum|r1_p1" id="884" />
-          <Map s="Organism|Lumen|UpperJejunum|r1_p0" id="885" />
-          <Map s="Organism|Lumen|UpperJejunum|Microvilli factor" id="886" />
-          <Map s="Organism|Lumen|UpperJejunum|MoleculeProperties|Partition coefficient (water/container)" id="887" />
-          <Map s="Organism|Lumen|UpperJejunum|MoleculeProperties|Oral mass absorbed segment" id="888" />
-          <Map s="Organism|Lumen|LowerJejunum|pH" id="889" />
-          <Map s="Organism|Lumen|LowerJejunum|Microvilli factor" id="890" />
-          <Map s="Organism|Lumen|LowerJejunum|L_p1" id="891" />
-          <Map s="Organism|Lumen|LowerJejunum|L_p0" id="892" />
-          <Map s="Organism|Lumen|LowerJejunum|Intestinal transit rate" id="893" />
-          <Map s="Organism|Lumen|LowerJejunum|Fractional steady state fill level" id="894" />
-          <Map s="Organism|Lumen|LowerJejunum|r2_p0" id="895" />
-          <Map s="Organism|Lumen|LowerJejunum|Effective surface area enhancement factor" id="896" />
-          <Map s="Organism|Lumen|LowerJejunum|r1_p0" id="897" />
-          <Map s="Organism|Lumen|LowerJejunum|r1_p1" id="898" />
-          <Map s="Organism|Lumen|LowerJejunum|Thickness_p3" id="899" />
-          <Map s="Organism|Lumen|LowerJejunum|Thickness_p2" id="900" />
-          <Map s="Organism|Lumen|LowerJejunum|Thickness_p1" id="901" />
-          <Map s="Organism|Lumen|LowerJejunum|r2_p1" id="902" />
-          <Map s="Organism|Lumen|LowerJejunum|MoleculeProperties|Oral mass absorbed segment" id="903" />
-          <Map s="Organism|Lumen|LowerJejunum|MoleculeProperties|Partition coefficient (water/container)" id="904" />
-          <Map s="Organism|Lumen|UpperIleum|pH" id="905" />
-          <Map s="Organism|Lumen|UpperIleum|Thickness_p3" id="906" />
-          <Map s="Organism|Lumen|UpperIleum|r2_p1" id="907" />
-          <Map s="Organism|Lumen|UpperIleum|Thickness_p2" id="908" />
-          <Map s="Organism|Lumen|UpperIleum|Fractional steady state fill level" id="909" />
-          <Map s="Organism|Lumen|UpperIleum|r2_p0" id="910" />
-          <Map s="Organism|Lumen|UpperIleum|r1_p1" id="911" />
-          <Map s="Organism|Lumen|UpperIleum|r1_p0" id="912" />
-          <Map s="Organism|Lumen|UpperIleum|Microvilli factor" id="913" />
-          <Map s="Organism|Lumen|UpperIleum|L_p1" id="914" />
-          <Map s="Organism|Lumen|UpperIleum|Intestinal transit rate" id="915" />
-          <Map s="Organism|Lumen|UpperIleum|Effective surface area enhancement factor" id="916" />
-          <Map s="Organism|Lumen|UpperIleum|Thickness_p1" id="917" />
-          <Map s="Organism|Lumen|UpperIleum|L_p0" id="918" />
-          <Map s="Organism|Lumen|UpperIleum|MoleculeProperties|Oral mass absorbed segment" id="919" />
-          <Map s="Organism|Lumen|UpperIleum|MoleculeProperties|Partition coefficient (water/container)" id="920" />
-          <Map s="Organism|Lumen|LowerIleum|Microvilli factor" id="921" />
-          <Map s="Organism|Lumen|LowerIleum|Thickness_p1" id="922" />
-          <Map s="Organism|Lumen|LowerIleum|r2_p1" id="923" />
-          <Map s="Organism|Lumen|LowerIleum|r2_p0" id="924" />
-          <Map s="Organism|Lumen|LowerIleum|r1_p1" id="925" />
-          <Map s="Organism|Lumen|LowerIleum|Thickness_p3" id="926" />
-          <Map s="Organism|Lumen|LowerIleum|pH" id="927" />
-          <Map s="Organism|Lumen|LowerIleum|L_p1" id="928" />
-          <Map s="Organism|Lumen|LowerIleum|L_p0" id="929" />
-          <Map s="Organism|Lumen|LowerIleum|Intestinal transit rate" id="930" />
-          <Map s="Organism|Lumen|LowerIleum|Fractional steady state fill level" id="931" />
-          <Map s="Organism|Lumen|LowerIleum|Effective surface area enhancement factor" id="932" />
-          <Map s="Organism|Lumen|LowerIleum|r1_p0" id="933" />
-          <Map s="Organism|Lumen|LowerIleum|Thickness_p2" id="934" />
-          <Map s="Organism|Lumen|LowerIleum|MoleculeProperties|Partition coefficient (water/container)" id="935" />
-          <Map s="Organism|Lumen|LowerIleum|MoleculeProperties|Oral mass absorbed segment" id="936" />
-          <Map s="Organism|Lumen|Caecum|pH" id="937" />
-          <Map s="Organism|Lumen|Caecum|Effective surface area enhancement factor" id="938" />
-          <Map s="Organism|Lumen|Caecum|r1_p1" id="939" />
-          <Map s="Organism|Lumen|Caecum|Thickness_p3" id="940" />
-          <Map s="Organism|Lumen|Caecum|Thickness_p2" id="941" />
-          <Map s="Organism|Lumen|Caecum|Thickness_p1" id="942" />
-          <Map s="Organism|Lumen|Caecum|r2_p0" id="943" />
-          <Map s="Organism|Lumen|Caecum|r1_p0" id="944" />
-          <Map s="Organism|Lumen|Caecum|Microvilli factor" id="945" />
-          <Map s="Organism|Lumen|Caecum|L_p1" id="946" />
-          <Map s="Organism|Lumen|Caecum|L_p0" id="947" />
-          <Map s="Organism|Lumen|Caecum|Intestinal transit rate" id="948" />
-          <Map s="Organism|Lumen|Caecum|Fractional steady state fill level" id="949" />
-          <Map s="Organism|Lumen|Caecum|r2_p1" id="950" />
-          <Map s="Organism|Lumen|Caecum|MoleculeProperties|Partition coefficient (water/container)" id="951" />
-          <Map s="Organism|Lumen|Caecum|MoleculeProperties|Oral mass absorbed segment" id="952" />
-          <Map s="Organism|Lumen|ColonAscendens|r2_p1" id="953" />
-          <Map s="Organism|Lumen|ColonAscendens|Thickness_p3" id="954" />
-          <Map s="Organism|Lumen|ColonAscendens|Thickness_p1" id="955" />
-          <Map s="Organism|Lumen|ColonAscendens|r2_p0" id="956" />
-          <Map s="Organism|Lumen|ColonAscendens|r1_p1" id="957" />
-          <Map s="Organism|Lumen|ColonAscendens|r1_p0" id="958" />
-          <Map s="Organism|Lumen|ColonAscendens|pH" id="959" />
-          <Map s="Organism|Lumen|ColonAscendens|Microvilli factor" id="960" />
-          <Map s="Organism|Lumen|ColonAscendens|L_p1" id="961" />
-          <Map s="Organism|Lumen|ColonAscendens|Thickness_p2" id="962" />
-          <Map s="Organism|Lumen|ColonAscendens|Fractional steady state fill level" id="963" />
-          <Map s="Organism|Lumen|ColonAscendens|L_p0" id="964" />
-          <Map s="Organism|Lumen|ColonAscendens|Effective surface area enhancement factor" id="965" />
-          <Map s="Organism|Lumen|ColonAscendens|Intestinal transit rate" id="966" />
-          <Map s="Organism|Lumen|ColonAscendens|MoleculeProperties|Partition coefficient (water/container)" id="967" />
-          <Map s="Organism|Lumen|ColonAscendens|MoleculeProperties|Oral mass absorbed segment" id="968" />
-          <Map s="Organism|Lumen|ColonTransversum|Intestinal transit rate" id="969" />
-          <Map s="Organism|Lumen|ColonTransversum|Fractional steady state fill level" id="970" />
-          <Map s="Organism|Lumen|ColonTransversum|Effective surface area enhancement factor" id="971" />
-          <Map s="Organism|Lumen|ColonTransversum|L_p1" id="972" />
-          <Map s="Organism|Lumen|ColonTransversum|Microvilli factor" id="973" />
-          <Map s="Organism|Lumen|ColonTransversum|Thickness_p2" id="974" />
-          <Map s="Organism|Lumen|ColonTransversum|L_p0" id="975" />
-          <Map s="Organism|Lumen|ColonTransversum|Thickness_p3" id="976" />
-          <Map s="Organism|Lumen|ColonTransversum|Thickness_p1" id="977" />
-          <Map s="Organism|Lumen|ColonTransversum|r2_p1" id="978" />
-          <Map s="Organism|Lumen|ColonTransversum|r2_p0" id="979" />
-          <Map s="Organism|Lumen|ColonTransversum|r1_p1" id="980" />
-          <Map s="Organism|Lumen|ColonTransversum|r1_p0" id="981" />
-          <Map s="Organism|Lumen|ColonTransversum|pH" id="982" />
-          <Map s="Organism|Lumen|ColonTransversum|MoleculeProperties|Partition coefficient (water/container)" id="983" />
-          <Map s="Organism|Lumen|ColonTransversum|MoleculeProperties|Oral mass absorbed segment" id="984" />
-          <Map s="Organism|Lumen|ColonDescendens|r1_p0" id="985" />
-          <Map s="Organism|Lumen|ColonDescendens|Thickness_p3" id="986" />
-          <Map s="Organism|Lumen|ColonDescendens|Thickness_p2" id="987" />
-          <Map s="Organism|Lumen|ColonDescendens|Thickness_p1" id="988" />
-          <Map s="Organism|Lumen|ColonDescendens|r2_p1" id="989" />
-          <Map s="Organism|Lumen|ColonDescendens|r2_p0" id="990" />
-          <Map s="Organism|Lumen|ColonDescendens|pH" id="991" />
-          <Map s="Organism|Lumen|ColonDescendens|r1_p1" id="992" />
-          <Map s="Organism|Lumen|ColonDescendens|Microvilli factor" id="993" />
-          <Map s="Organism|Lumen|ColonDescendens|L_p1" id="994" />
-          <Map s="Organism|Lumen|ColonDescendens|L_p0" id="995" />
-          <Map s="Organism|Lumen|ColonDescendens|Intestinal transit rate" id="996" />
-          <Map s="Organism|Lumen|ColonDescendens|Fractional steady state fill level" id="997" />
-          <Map s="Organism|Lumen|ColonDescendens|Effective surface area enhancement factor" id="998" />
-          <Map s="Organism|Lumen|ColonDescendens|MoleculeProperties|Partition coefficient (water/container)" id="999" />
-          <Map s="Organism|Lumen|ColonDescendens|MoleculeProperties|Oral mass absorbed segment" id="1000" />
-          <Map s="Organism|Lumen|ColonSigmoid|Effective surface area enhancement factor" id="1001" />
-          <Map s="Organism|Lumen|ColonSigmoid|pH" id="1002" />
-          <Map s="Organism|Lumen|ColonSigmoid|Microvilli factor" id="1003" />
-          <Map s="Organism|Lumen|ColonSigmoid|L_p1" id="1004" />
-          <Map s="Organism|Lumen|ColonSigmoid|L_p0" id="1005" />
-          <Map s="Organism|Lumen|ColonSigmoid|r1_p1" id="1006" />
-          <Map s="Organism|Lumen|ColonSigmoid|Fractional steady state fill level" id="1007" />
-          <Map s="Organism|Lumen|ColonSigmoid|r2_p0" id="1008" />
-          <Map s="Organism|Lumen|ColonSigmoid|Intestinal transit rate" id="1009" />
-          <Map s="Organism|Lumen|ColonSigmoid|r1_p0" id="1010" />
-          <Map s="Organism|Lumen|ColonSigmoid|Thickness_p3" id="1011" />
-          <Map s="Organism|Lumen|ColonSigmoid|Thickness_p2" id="1012" />
-          <Map s="Organism|Lumen|ColonSigmoid|Thickness_p1" id="1013" />
-          <Map s="Organism|Lumen|ColonSigmoid|r2_p1" id="1014" />
-          <Map s="Organism|Lumen|ColonSigmoid|MoleculeProperties|Partition coefficient (water/container)" id="1015" />
-          <Map s="Organism|Lumen|ColonSigmoid|MoleculeProperties|Oral mass absorbed segment" id="1016" />
-          <Map s="Organism|Lumen|Rectum|Intestinal transit rate" id="1017" />
-          <Map s="Organism|Lumen|Rectum|r2_p0" id="1018" />
-          <Map s="Organism|Lumen|Rectum|r1_p1" id="1019" />
-          <Map s="Organism|Lumen|Rectum|r1_p0" id="1020" />
-          <Map s="Organism|Lumen|Rectum|pH" id="1021" />
-          <Map s="Organism|Lumen|Rectum|Microvilli factor" id="1022" />
-          <Map s="Organism|Lumen|Rectum|L_p0" id="1023" />
-          <Map s="Organism|Lumen|Rectum|Fractional steady state fill level" id="1024" />
-          <Map s="Organism|Lumen|Rectum|Effective surface area enhancement factor" id="1025" />
-          <Map s="Organism|Lumen|Rectum|L_p1" id="1026" />
-          <Map s="Organism|Lumen|Rectum|Thickness_p2" id="1027" />
-          <Map s="Organism|Lumen|Rectum|r2_p1" id="1028" />
-          <Map s="Organism|Lumen|Rectum|Thickness_p3" id="1029" />
-          <Map s="Organism|Lumen|Rectum|Thickness_p1" id="1030" />
-          <Map s="Organism|Lumen|Rectum|MoleculeProperties|Oral mass absorbed segment" id="1031" />
-          <Map s="Organism|Lumen|Rectum|MoleculeProperties|Partition coefficient (water/container)" id="1032" />
-          <Map s="Organism|Lumen|Feces|Liquid" id="1033" />
-          <Map s="Organism|Lumen|Feces|Volume" id="1034" />
-          <Map s="Organism|Stomach|Allometric scale factor" id="1035" />
-          <Map s="Organism|Stomach|Density (tissue)" id="1036" />
-          <Map s="Organism|Stomach|Fraction of blood for sampling" id="1037" />
-          <Map s="Organism|Stomach|Flow fraction via large pores" id="1038" />
-          <Map s="Organism|Stomach|Radius (small pores)" id="1039" />
-          <Map s="Organism|Stomach|Fluid recirculation flow rate" id="1040" />
-          <Map s="Organism|Stomach|Radius (large pores)" id="1041" />
-          <Map s="Organism|Stomach|Hydraulic conductivity" id="1042" />
-          <Map s="Organism|Stomach|Lymph flow rate" id="1043" />
-          <Map s="Organism|Stomach|Vf (lipid)" id="1044" />
-          <Map s="Organism|Stomach|Vf (neutral lipid)-PT" id="1045" />
-          <Map s="Organism|Stomach|Fraction vascular" id="1046" />
-          <Map s="Organism|Stomach|Vf (phospholipid)-PT" id="1047" />
-          <Map s="Organism|Stomach|Vf (protein)" id="1048" />
-          <Map s="Organism|Stomach|Albumin ratio (tissue/plasma)" id="1049" />
-          <Map s="Organism|Stomach|Lipoprotein ratio (tissue/plasma)" id="1050" />
-          <Map s="Organism|Stomach|Vf (water)" id="1051" />
-          <Map s="Organism|Stomach|Vf (water)-PT" id="1052" />
-          <Map s="Organism|Stomach|Albumin ratio (tissue/plasma)-PT" id="1053" />
-          <Map s="Organism|Stomach|Microsomal protein mass/g tissue" id="1054" />
-          <Map s="Organism|Stomach|Number of cells/g tissue" id="1055" />
-          <Map s="Organism|Stomach|Protein mass/g tissue" id="1056" />
-          <Map s="Organism|Stomach|Fraction interstitial" id="1057" />
-          <Map s="Organism|Stomach|Vf (neutral lipid)-WS" id="1058" />
-          <Map s="Organism|Stomach|Vf (neutral lipid)-RR" id="1059" />
-          <Map s="Organism|Stomach|Vf (neutral phospholipid)-RR" id="1060" />
-          <Map s="Organism|Stomach|Vf (neutral phospholipid, plasma)-WS" id="1061" />
-          <Map s="Organism|Stomach|Vf (extracellular water)-RR" id="1062" />
-          <Map s="Organism|Stomach|Vf (protein)-WS" id="1063" />
-          <Map s="Organism|Stomach|Vf (intracellular water)-RR" id="1064" />
-          <Map s="Organism|Stomach|Vf (water)-WS" id="1065" />
-          <Map s="Organism|Stomach|Vf (acidic phospholipids)-WS" id="1066" />
-          <Map s="Organism|Stomach|Acidic phospholipids [mg/g] - RR" id="1067" />
-          <Map s="Organism|Stomach|Volume|Percentile" id="1068" />
-          <Map s="Organism|Stomach|Volume|Mean" id="1069" />
-          <Map s="Organism|Stomach|Volume|Deviation" id="1070" />
-          <Map s="Organism|Stomach|Specific blood flow rate|Percentile" id="1071" />
-          <Map s="Organism|Stomach|Specific blood flow rate|Mean" id="1072" />
-          <Map s="Organism|Stomach|Specific blood flow rate|Deviation" id="1073" />
-          <Map s="Organism|Stomach|Intracellular|pH" id="1074" />
-          <Map s="Organism|SmallIntestine|Allometric scale factor" id="1075" />
-          <Map s="Organism|SmallIntestine|Density (tissue)" id="1076" />
-          <Map s="Organism|SmallIntestine|Colon_Arrival_Time_Intercept_a0" id="1077" />
-          <Map s="Organism|SmallIntestine|Colon arrival time" id="1078" />
-          <Map s="Organism|SmallIntestine|Mucosa blood flow fraction" id="1079" />
-          <Map s="Organism|SmallIntestine|Colon_Arrival_Time_Slope_a2" id="1080" />
-          <Map s="Organism|SmallIntestine|Colon_Arrival_Time_Slope_a1" id="1081" />
-          <Map s="Organism|SmallIntestine|Colon_Arrival_Time_Slope_a0" id="1082" />
-          <Map s="Organism|SmallIntestine|Colon_Arrival_Time_Intercept_a1" id="1083" />
-          <Map s="Organism|SmallIntestine|Fraction of blood for sampling" id="1084" />
-          <Map s="Organism|SmallIntestine|Lymph flow rate (incl. mucosa)" id="1085" />
-          <Map s="Organism|SmallIntestine|Flow fraction via large pores" id="1086" />
-          <Map s="Organism|SmallIntestine|Fluid recirculation flow rate (incl. mucosa)" id="1087" />
-          <Map s="Organism|SmallIntestine|Hydraulic conductivity" id="1088" />
-          <Map s="Organism|SmallIntestine|Radius (small pores)" id="1089" />
-          <Map s="Organism|SmallIntestine|Radius (large pores)" id="1090" />
-          <Map s="Organism|SmallIntestine|Vf (lipid)" id="1091" />
-          <Map s="Organism|SmallIntestine|Vf (neutral lipid)-PT" id="1092" />
-          <Map s="Organism|SmallIntestine|Fraction vascular" id="1093" />
-          <Map s="Organism|SmallIntestine|Vf (phospholipid)-PT" id="1094" />
-          <Map s="Organism|SmallIntestine|Vf (protein)" id="1095" />
-          <Map s="Organism|SmallIntestine|Vf (water)-PT" id="1096" />
-          <Map s="Organism|SmallIntestine|Vf (water)" id="1097" />
-          <Map s="Organism|SmallIntestine|Lipoprotein ratio (tissue/plasma)" id="1098" />
-          <Map s="Organism|SmallIntestine|Albumin ratio (tissue/plasma)-PT" id="1099" />
-          <Map s="Organism|SmallIntestine|Albumin ratio (tissue/plasma)" id="1100" />
-          <Map s="Organism|SmallIntestine|Microsomal protein mass/g tissue" id="1101" />
-          <Map s="Organism|SmallIntestine|Number of cells/g tissue" id="1102" />
-          <Map s="Organism|SmallIntestine|Protein mass/g tissue" id="1103" />
-          <Map s="Organism|SmallIntestine|Fraction interstitial" id="1104" />
-          <Map s="Organism|SmallIntestine|Vf (neutral lipid)-RR" id="1105" />
-          <Map s="Organism|SmallIntestine|Vf (neutral lipid)-WS" id="1106" />
-          <Map s="Organism|SmallIntestine|Vf (neutral phospholipid, plasma)-WS" id="1107" />
-          <Map s="Organism|SmallIntestine|Vf (neutral phospholipid)-RR" id="1108" />
-          <Map s="Organism|SmallIntestine|Vf (protein)-WS" id="1109" />
-          <Map s="Organism|SmallIntestine|Vf (extracellular water)-RR" id="1110" />
-          <Map s="Organism|SmallIntestine|Vf (intracellular water)-RR" id="1111" />
-          <Map s="Organism|SmallIntestine|Vf (water)-WS" id="1112" />
-          <Map s="Organism|SmallIntestine|Acidic phospholipids [mg/g] - RR" id="1113" />
-          <Map s="Organism|SmallIntestine|Vf (acidic phospholipids)-WS" id="1114" />
-          <Map s="Organism|SmallIntestine|Volume|Percentile" id="1115" />
-          <Map s="Organism|SmallIntestine|Volume|Mean" id="1116" />
-          <Map s="Organism|SmallIntestine|Volume|Deviation" id="1117" />
-          <Map s="Organism|SmallIntestine|Specific blood flow rate|Percentile" id="1118" />
-          <Map s="Organism|SmallIntestine|Specific blood flow rate|Mean" id="1119" />
-          <Map s="Organism|SmallIntestine|Specific blood flow rate|Deviation" id="1120" />
-          <Map s="Organism|SmallIntestine|Intracellular|pH" id="1121" />
-          <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Density (tissue)" id="1122" />
-          <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Fraction mucosa" id="1123" />
-          <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Fraction of regional blood flow rate" id="1124" />
-          <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Fraction of blood for sampling" id="1125" />
-          <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Flow fraction via large pores" id="1126" />
-          <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Hydraulic conductivity" id="1127" />
-          <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Radius (large pores)" id="1128" />
-          <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Radius (small pores)" id="1129" />
-          <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Vf (neutral lipid)-PT" id="1130" />
-          <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Vf (lipid)" id="1131" />
-          <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Fraction vascular" id="1132" />
-          <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Vf (phospholipid)-PT" id="1133" />
-          <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Vf (protein)" id="1134" />
-          <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Lipoprotein ratio (tissue/plasma)" id="1135" />
-          <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Vf (water)" id="1136" />
-          <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Vf (water)-PT" id="1137" />
-          <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Albumin ratio (tissue/plasma)-PT" id="1138" />
-          <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Albumin ratio (tissue/plasma)" id="1139" />
-          <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Microsomal protein mass/g tissue" id="1140" />
-          <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Number of cells/g tissue" id="1141" />
-          <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Protein mass/g tissue" id="1142" />
-          <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Fraction interstitial" id="1143" />
-          <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Vf (neutral lipid)-WS" id="1144" />
-          <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Vf (neutral lipid)-RR" id="1145" />
-          <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Vf (neutral phospholipid)-RR" id="1146" />
-          <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Vf (neutral phospholipid, plasma)-WS" id="1147" />
-          <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Vf (extracellular water)-RR" id="1148" />
-          <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Vf (protein)-WS" id="1149" />
-          <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Vf (intracellular water)-RR" id="1150" />
-          <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Vf (water)-WS" id="1151" />
-          <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Acidic phospholipids [mg/g] - RR" id="1152" />
-          <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Vf (acidic phospholipids)-WS" id="1153" />
-          <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|pH" id="1154" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Density (tissue)" id="1155" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Fraction of regional blood flow rate" id="1156" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Fraction mucosa" id="1157" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Fraction of blood for sampling" id="1158" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Radius (small pores)" id="1159" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Radius (large pores)" id="1160" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Flow fraction via large pores" id="1161" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Hydraulic conductivity" id="1162" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Vf (neutral lipid)-PT" id="1163" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Vf (lipid)" id="1164" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Fraction vascular" id="1165" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Vf (phospholipid)-PT" id="1166" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Vf (protein)" id="1167" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Albumin ratio (tissue/plasma)" id="1168" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Lipoprotein ratio (tissue/plasma)" id="1169" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Albumin ratio (tissue/plasma)-PT" id="1170" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Vf (water)-PT" id="1171" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Vf (water)" id="1172" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Microsomal protein mass/g tissue" id="1173" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Number of cells/g tissue" id="1174" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Protein mass/g tissue" id="1175" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Fraction interstitial" id="1176" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Vf (neutral lipid)-WS" id="1177" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Vf (neutral lipid)-RR" id="1178" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Vf (neutral phospholipid, plasma)-WS" id="1179" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Vf (neutral phospholipid)-RR" id="1180" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Vf (protein)-WS" id="1181" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Vf (extracellular water)-RR" id="1182" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Vf (water)-WS" id="1183" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Vf (intracellular water)-RR" id="1184" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Acidic phospholipids [mg/g] - RR" id="1185" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Vf (acidic phospholipids)-WS" id="1186" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|pH" id="1187" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Density (tissue)" id="1188" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Fraction of regional blood flow rate" id="1189" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Fraction mucosa" id="1190" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Fraction of blood for sampling" id="1191" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Radius (large pores)" id="1192" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Radius (small pores)" id="1193" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Hydraulic conductivity" id="1194" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Flow fraction via large pores" id="1195" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Vf (neutral lipid)-PT" id="1196" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Vf (lipid)" id="1197" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Fraction vascular" id="1198" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Vf (phospholipid)-PT" id="1199" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Vf (protein)" id="1200" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Albumin ratio (tissue/plasma)-PT" id="1201" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Lipoprotein ratio (tissue/plasma)" id="1202" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Albumin ratio (tissue/plasma)" id="1203" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Vf (water)" id="1204" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Vf (water)-PT" id="1205" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Microsomal protein mass/g tissue" id="1206" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Number of cells/g tissue" id="1207" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Protein mass/g tissue" id="1208" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Fraction interstitial" id="1209" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Vf (neutral lipid)-RR" id="1210" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Vf (neutral lipid)-WS" id="1211" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Vf (neutral phospholipid, plasma)-WS" id="1212" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Vf (neutral phospholipid)-RR" id="1213" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Vf (extracellular water)-RR" id="1214" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Vf (protein)-WS" id="1215" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Vf (water)-WS" id="1216" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Vf (intracellular water)-RR" id="1217" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Acidic phospholipids [mg/g] - RR" id="1218" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Vf (acidic phospholipids)-WS" id="1219" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|pH" id="1220" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Density (tissue)" id="1221" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Fraction of regional blood flow rate" id="1222" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Fraction mucosa" id="1223" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Fraction of blood for sampling" id="1224" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Flow fraction via large pores" id="1225" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Hydraulic conductivity" id="1226" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Radius (large pores)" id="1227" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Radius (small pores)" id="1228" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Vf (lipid)" id="1229" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Vf (neutral lipid)-PT" id="1230" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Fraction vascular" id="1231" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Vf (protein)" id="1232" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Vf (phospholipid)-PT" id="1233" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Albumin ratio (tissue/plasma)-PT" id="1234" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Albumin ratio (tissue/plasma)" id="1235" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Lipoprotein ratio (tissue/plasma)" id="1236" />
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-          <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Vf (water)-PT" id="1238" />
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-          <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Vf (neutral lipid)-WS" id="1243" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Vf (neutral lipid)-RR" id="1244" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Vf (neutral phospholipid)-RR" id="1245" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Vf (neutral phospholipid, plasma)-WS" id="1246" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Vf (extracellular water)-RR" id="1247" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Vf (protein)-WS" id="1248" />
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-          <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Vf (intracellular water)-RR" id="1250" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Vf (acidic phospholipids)-WS" id="1251" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Acidic phospholipids [mg/g] - RR" id="1252" />
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-          <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Fraction of blood for sampling" id="1257" />
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-          <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Radius (small pores)" id="1259" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Flow fraction via large pores" id="1260" />
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-          <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Vf (neutral lipid)-PT" id="1262" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Vf (lipid)" id="1263" />
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-          <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Vf (protein)" id="1266" />
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-          <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Vf (water)-PT" id="1268" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Vf (water)" id="1269" />
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-          <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Lipoprotein ratio (tissue/plasma)" id="1271" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Protein mass/g tissue" id="1272" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Microsomal protein mass/g tissue" id="1273" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Number of cells/g tissue" id="1274" />
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-          <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Vf (neutral lipid)-WS" id="1276" />
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-          <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Vf (neutral phospholipid, plasma)-WS" id="1278" />
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-          <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Vf (protein)-WS" id="1280" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Vf (extracellular water)-RR" id="1281" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Vf (water)-WS" id="1282" />
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-          <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Acidic phospholipids [mg/g] - RR" id="1285" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|pH" id="1286" />
-          <Map s="Organism|LargeIntestine|Allometric scale factor" id="1287" />
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-          <Map s="Organism|LargeIntestine|Excretion_Time_k2" id="1289" />
-          <Map s="Organism|LargeIntestine|Excretion_Time_k1" id="1290" />
-          <Map s="Organism|LargeIntestine|Excretion_Time_k0" id="1291" />
-          <Map s="Organism|LargeIntestine|Excretion time" id="1292" />
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-          <Map s="Organism|LargeIntestine|Fraction of blood for sampling" id="1294" />
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-          <Map s="Organism|LargeIntestine|Radius (large pores)" id="1296" />
-          <Map s="Organism|LargeIntestine|Lymph flow rate (incl. mucosa)" id="1297" />
-          <Map s="Organism|LargeIntestine|Hydraulic conductivity" id="1298" />
-          <Map s="Organism|LargeIntestine|Fluid recirculation flow rate (incl. mucosa)" id="1299" />
-          <Map s="Organism|LargeIntestine|Flow fraction via large pores" id="1300" />
-          <Map s="Organism|LargeIntestine|Vf (neutral lipid)-PT" id="1301" />
-          <Map s="Organism|LargeIntestine|Vf (lipid)" id="1302" />
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-          <Map s="Organism|LargeIntestine|Vf (phospholipid)-PT" id="1304" />
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-          <Map s="Organism|LargeIntestine|Lipoprotein ratio (tissue/plasma)" id="1308" />
-          <Map s="Organism|LargeIntestine|Vf (water)" id="1309" />
-          <Map s="Organism|LargeIntestine|Vf (water)-PT" id="1310" />
-          <Map s="Organism|LargeIntestine|Protein mass/g tissue" id="1311" />
-          <Map s="Organism|LargeIntestine|Microsomal protein mass/g tissue" id="1312" />
-          <Map s="Organism|LargeIntestine|Number of cells/g tissue" id="1313" />
-          <Map s="Organism|LargeIntestine|Fraction interstitial" id="1314" />
-          <Map s="Organism|LargeIntestine|Vf (neutral lipid)-RR" id="1315" />
-          <Map s="Organism|LargeIntestine|Vf (neutral lipid)-WS" id="1316" />
-          <Map s="Organism|LargeIntestine|Vf (neutral phospholipid)-RR" id="1317" />
-          <Map s="Organism|LargeIntestine|Vf (neutral phospholipid, plasma)-WS" id="1318" />
-          <Map s="Organism|LargeIntestine|Vf (extracellular water)-RR" id="1319" />
-          <Map s="Organism|LargeIntestine|Vf (protein)-WS" id="1320" />
-          <Map s="Organism|LargeIntestine|Vf (intracellular water)-RR" id="1321" />
-          <Map s="Organism|LargeIntestine|Vf (water)-WS" id="1322" />
-          <Map s="Organism|LargeIntestine|Vf (acidic phospholipids)-WS" id="1323" />
-          <Map s="Organism|LargeIntestine|Acidic phospholipids [mg/g] - RR" id="1324" />
-          <Map s="Organism|LargeIntestine|Volume|Percentile" id="1325" />
-          <Map s="Organism|LargeIntestine|Volume|Mean" id="1326" />
-          <Map s="Organism|LargeIntestine|Volume|Deviation" id="1327" />
-          <Map s="Organism|LargeIntestine|Specific blood flow rate|Percentile" id="1328" />
-          <Map s="Organism|LargeIntestine|Specific blood flow rate|Mean" id="1329" />
-          <Map s="Organism|LargeIntestine|Specific blood flow rate|Deviation" id="1330" />
-          <Map s="Organism|LargeIntestine|Intracellular|pH" id="1331" />
-          <Map s="Organism|LargeIntestine|Mucosa|Caecum|Density (tissue)" id="1332" />
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-          <Map s="Organism|LargeIntestine|Mucosa|Caecum|Fraction mucosa" id="1334" />
-          <Map s="Organism|LargeIntestine|Mucosa|Caecum|Fraction of blood for sampling" id="1335" />
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-          <Map s="Organism|LargeIntestine|Mucosa|Caecum|Radius (large pores)" id="1337" />
-          <Map s="Organism|LargeIntestine|Mucosa|Caecum|Hydraulic conductivity" id="1338" />
-          <Map s="Organism|LargeIntestine|Mucosa|Caecum|Flow fraction via large pores" id="1339" />
-          <Map s="Organism|LargeIntestine|Mucosa|Caecum|Vf (lipid)" id="1340" />
-          <Map s="Organism|LargeIntestine|Mucosa|Caecum|Vf (neutral lipid)-PT" id="1341" />
-          <Map s="Organism|LargeIntestine|Mucosa|Caecum|Fraction vascular" id="1342" />
-          <Map s="Organism|LargeIntestine|Mucosa|Caecum|Vf (protein)" id="1343" />
-          <Map s="Organism|LargeIntestine|Mucosa|Caecum|Vf (phospholipid)-PT" id="1344" />
-          <Map s="Organism|LargeIntestine|Mucosa|Caecum|Albumin ratio (tissue/plasma)" id="1345" />
-          <Map s="Organism|LargeIntestine|Mucosa|Caecum|Vf (water)-PT" id="1346" />
-          <Map s="Organism|LargeIntestine|Mucosa|Caecum|Vf (water)" id="1347" />
-          <Map s="Organism|LargeIntestine|Mucosa|Caecum|Lipoprotein ratio (tissue/plasma)" id="1348" />
-          <Map s="Organism|LargeIntestine|Mucosa|Caecum|Albumin ratio (tissue/plasma)-PT" id="1349" />
-          <Map s="Organism|LargeIntestine|Mucosa|Caecum|Microsomal protein mass/g tissue" id="1350" />
-          <Map s="Organism|LargeIntestine|Mucosa|Caecum|Number of cells/g tissue" id="1351" />
-          <Map s="Organism|LargeIntestine|Mucosa|Caecum|Protein mass/g tissue" id="1352" />
-          <Map s="Organism|LargeIntestine|Mucosa|Caecum|Fraction interstitial" id="1353" />
-          <Map s="Organism|LargeIntestine|Mucosa|Caecum|Vf (neutral lipid)-WS" id="1354" />
-          <Map s="Organism|LargeIntestine|Mucosa|Caecum|Vf (neutral lipid)-RR" id="1355" />
-          <Map s="Organism|LargeIntestine|Mucosa|Caecum|Vf (neutral phospholipid, plasma)-WS" id="1356" />
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-          <Map s="Organism|LargeIntestine|Mucosa|Caecum|Vf (protein)-WS" id="1358" />
-          <Map s="Organism|LargeIntestine|Mucosa|Caecum|Vf (extracellular water)-RR" id="1359" />
-          <Map s="Organism|LargeIntestine|Mucosa|Caecum|Vf (intracellular water)-RR" id="1360" />
-          <Map s="Organism|LargeIntestine|Mucosa|Caecum|Vf (water)-WS" id="1361" />
-          <Map s="Organism|LargeIntestine|Mucosa|Caecum|Vf (acidic phospholipids)-WS" id="1362" />
-          <Map s="Organism|LargeIntestine|Mucosa|Caecum|Acidic phospholipids [mg/g] - RR" id="1363" />
-          <Map s="Organism|LargeIntestine|Mucosa|Caecum|Intracellular|pH" id="1364" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonAscendens|Density (tissue)" id="1365" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonAscendens|Fraction of regional blood flow rate" id="1366" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonAscendens|Fraction mucosa" id="1367" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonAscendens|Fraction of blood for sampling" id="1368" />
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-          <Map s="Organism|LargeIntestine|Mucosa|ColonAscendens|Radius (large pores)" id="1370" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonAscendens|Hydraulic conductivity" id="1371" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonAscendens|Flow fraction via large pores" id="1372" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonAscendens|Vf (lipid)" id="1373" />
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-          <Map s="Organism|LargeIntestine|Mucosa|ColonAscendens|Fraction vascular" id="1375" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonAscendens|Vf (protein)" id="1376" />
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-          <Map s="Organism|LargeIntestine|Mucosa|ColonAscendens|Vf (water)" id="1378" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonAscendens|Albumin ratio (tissue/plasma)" id="1379" />
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-          <Map s="Organism|LargeIntestine|Mucosa|ColonAscendens|Lipoprotein ratio (tissue/plasma)" id="1381" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonAscendens|Albumin ratio (tissue/plasma)-PT" id="1382" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonAscendens|Microsomal protein mass/g tissue" id="1383" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonAscendens|Protein mass/g tissue" id="1384" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonAscendens|Number of cells/g tissue" id="1385" />
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-          <Map s="Organism|LargeIntestine|Mucosa|ColonAscendens|Vf (protein)-WS" id="1392" />
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-          <Map s="Organism|LargeIntestine|Mucosa|ColonAscendens|Vf (acidic phospholipids)-WS" id="1395" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonAscendens|Acidic phospholipids [mg/g] - RR" id="1396" />
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-          <Map s="Organism|LargeIntestine|Mucosa|ColonTransversum|Vf (lipid)" id="1406" />
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-          <Map s="Organism|LargeIntestine|Mucosa|ColonTransversum|Albumin ratio (tissue/plasma)-PT" id="1414" />
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-          <Map s="Organism|LargeIntestine|Mucosa|ColonTransversum|Microsomal protein mass/g tissue" id="1416" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonTransversum|Protein mass/g tissue" id="1417" />
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-          <Map s="Organism|LargeIntestine|Mucosa|ColonDescendens|Vf (neutral lipid)-WS" id="1454" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonDescendens|Vf (neutral phospholipid)-RR" id="1455" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonDescendens|Vf (neutral phospholipid, plasma)-WS" id="1456" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonDescendens|Vf (protein)-WS" id="1457" />
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-          <Map s="Organism|LargeIntestine|Mucosa|ColonDescendens|Acidic phospholipids [mg/g] - RR" id="1461" />
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-          <Map s="Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|pH" id="1463" />
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-          <Map s="Organism|LargeIntestine|Mucosa|ColonSigmoid|Fraction mucosa" id="1465" />
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-          <Map s="Organism|LargeIntestine|Mucosa|ColonSigmoid|Fraction of blood for sampling" id="1467" />
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-          <Map s="Organism|LargeIntestine|Mucosa|ColonSigmoid|Radius (large pores)" id="1469" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonSigmoid|Hydraulic conductivity" id="1470" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonSigmoid|Flow fraction via large pores" id="1471" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonSigmoid|Vf (lipid)" id="1472" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonSigmoid|Vf (neutral lipid)-PT" id="1473" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonSigmoid|Fraction vascular" id="1474" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonSigmoid|Vf (protein)" id="1475" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonSigmoid|Vf (phospholipid)-PT" id="1476" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonSigmoid|Albumin ratio (tissue/plasma)" id="1477" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonSigmoid|Albumin ratio (tissue/plasma)-PT" id="1478" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonSigmoid|Lipoprotein ratio (tissue/plasma)" id="1479" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonSigmoid|Vf (water)-PT" id="1480" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonSigmoid|Vf (water)" id="1481" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonSigmoid|Microsomal protein mass/g tissue" id="1482" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonSigmoid|Number of cells/g tissue" id="1483" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonSigmoid|Protein mass/g tissue" id="1484" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonSigmoid|Fraction interstitial" id="1485" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonSigmoid|Vf (neutral lipid)-RR" id="1486" />
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-          <Map s="Organism|LargeIntestine|Mucosa|ColonSigmoid|Vf (neutral phospholipid, plasma)-WS" id="1488" />
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-          <Map s="Organism|LargeIntestine|Mucosa|ColonSigmoid|Vf (extracellular water)-RR" id="1490" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonSigmoid|Vf (protein)-WS" id="1491" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonSigmoid|Vf (intracellular water)-RR" id="1492" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonSigmoid|Vf (water)-WS" id="1493" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonSigmoid|Acidic phospholipids [mg/g] - RR" id="1494" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonSigmoid|Vf (acidic phospholipids)-WS" id="1495" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|pH" id="1496" />
-          <Map s="Organism|LargeIntestine|Mucosa|Rectum|Density (tissue)" id="1497" />
-          <Map s="Organism|LargeIntestine|Mucosa|Rectum|Fraction of regional blood flow rate" id="1498" />
-          <Map s="Organism|LargeIntestine|Mucosa|Rectum|Fraction mucosa" id="1499" />
-          <Map s="Organism|LargeIntestine|Mucosa|Rectum|Fraction of blood for sampling" id="1500" />
-          <Map s="Organism|LargeIntestine|Mucosa|Rectum|Radius (small pores)" id="1501" />
-          <Map s="Organism|LargeIntestine|Mucosa|Rectum|Flow fraction via large pores" id="1502" />
-          <Map s="Organism|LargeIntestine|Mucosa|Rectum|Hydraulic conductivity" id="1503" />
-          <Map s="Organism|LargeIntestine|Mucosa|Rectum|Radius (large pores)" id="1504" />
-          <Map s="Organism|LargeIntestine|Mucosa|Rectum|Vf (lipid)" id="1505" />
-          <Map s="Organism|LargeIntestine|Mucosa|Rectum|Vf (neutral lipid)-PT" id="1506" />
-          <Map s="Organism|LargeIntestine|Mucosa|Rectum|Fraction vascular" id="1507" />
-          <Map s="Organism|LargeIntestine|Mucosa|Rectum|Vf (phospholipid)-PT" id="1508" />
-          <Map s="Organism|LargeIntestine|Mucosa|Rectum|Vf (protein)" id="1509" />
-          <Map s="Organism|LargeIntestine|Mucosa|Rectum|Vf (water)-PT" id="1510" />
-          <Map s="Organism|LargeIntestine|Mucosa|Rectum|Albumin ratio (tissue/plasma)" id="1511" />
-          <Map s="Organism|LargeIntestine|Mucosa|Rectum|Albumin ratio (tissue/plasma)-PT" id="1512" />
-          <Map s="Organism|LargeIntestine|Mucosa|Rectum|Lipoprotein ratio (tissue/plasma)" id="1513" />
-          <Map s="Organism|LargeIntestine|Mucosa|Rectum|Vf (water)" id="1514" />
-          <Map s="Organism|LargeIntestine|Mucosa|Rectum|Protein mass/g tissue" id="1515" />
-          <Map s="Organism|LargeIntestine|Mucosa|Rectum|Number of cells/g tissue" id="1516" />
-          <Map s="Organism|LargeIntestine|Mucosa|Rectum|Microsomal protein mass/g tissue" id="1517" />
-          <Map s="Organism|LargeIntestine|Mucosa|Rectum|Fraction interstitial" id="1518" />
-          <Map s="Organism|LargeIntestine|Mucosa|Rectum|Vf (neutral lipid)-WS" id="1519" />
-          <Map s="Organism|LargeIntestine|Mucosa|Rectum|Vf (neutral lipid)-RR" id="1520" />
-          <Map s="Organism|LargeIntestine|Mucosa|Rectum|Vf (neutral phospholipid, plasma)-WS" id="1521" />
-          <Map s="Organism|LargeIntestine|Mucosa|Rectum|Vf (neutral phospholipid)-RR" id="1522" />
-          <Map s="Organism|LargeIntestine|Mucosa|Rectum|Vf (extracellular water)-RR" id="1523" />
-          <Map s="Organism|LargeIntestine|Mucosa|Rectum|Vf (protein)-WS" id="1524" />
-          <Map s="Organism|LargeIntestine|Mucosa|Rectum|Vf (intracellular water)-RR" id="1525" />
-          <Map s="Organism|LargeIntestine|Mucosa|Rectum|Vf (water)-WS" id="1526" />
-          <Map s="Organism|LargeIntestine|Mucosa|Rectum|Acidic phospholipids [mg/g] - RR" id="1527" />
-          <Map s="Organism|LargeIntestine|Mucosa|Rectum|Vf (acidic phospholipids)-WS" id="1528" />
-          <Map s="Organism|LargeIntestine|Mucosa|Rectum|Intracellular|pH" id="1529" />
-          <Map s="Organism|Liver|Allometric scale factor" id="1530" />
-          <Map s="Organism|Liver|EHC continuous fraction" id="1531" />
-          <Map s="Organism|Liver|Density (tissue)" id="1532" />
-          <Map s="Organism|Liver|Fraction of blood for sampling" id="1533" />
-          <Map s="Organism|Liver|Flow fraction via large pores" id="1534" />
-          <Map s="Organism|Liver|Fluid recirculation flow rate" id="1535" />
-          <Map s="Organism|Liver|Radius (small pores)" id="1536" />
-          <Map s="Organism|Liver|Radius (large pores)" id="1537" />
-          <Map s="Organism|Liver|Lymph flow rate" id="1538" />
-          <Map s="Organism|Liver|Hydraulic conductivity" id="1539" />
-          <Map s="Organism|Liver|Vf (lipid)" id="1540" />
-          <Map s="Organism|Liver|Vf (neutral lipid)-PT" id="1541" />
-          <Map s="Organism|Liver|Fraction vascular" id="1542" />
-          <Map s="Organism|Liver|Vf (protein)" id="1543" />
-          <Map s="Organism|Liver|Vf (phospholipid)-PT" id="1544" />
-          <Map s="Organism|Liver|Albumin ratio (tissue/plasma)-PT" id="1545" />
-          <Map s="Organism|Liver|Albumin ratio (tissue/plasma)" id="1546" />
-          <Map s="Organism|Liver|Lipoprotein ratio (tissue/plasma)" id="1547" />
-          <Map s="Organism|Liver|Vf (water)" id="1548" />
-          <Map s="Organism|Liver|Vf (water)-PT" id="1549" />
-          <Map s="Organism|Liver|Microsomal protein mass/g tissue" id="1550" />
-          <Map s="Organism|Liver|Number of cells/g tissue" id="1551" />
-          <Map s="Organism|Liver|Protein mass/g tissue" id="1552" />
-          <Map s="Organism|Liver|Fraction interstitial" id="1553" />
-          <Map s="Organism|Liver|Vf (neutral lipid)-RR" id="1554" />
-          <Map s="Organism|Liver|Vf (neutral lipid)-WS" id="1555" />
-          <Map s="Organism|Liver|Vf (neutral phospholipid)-RR" id="1556" />
-          <Map s="Organism|Liver|Vf (neutral phospholipid, plasma)-WS" id="1557" />
-          <Map s="Organism|Liver|Vf (extracellular water)-RR" id="1558" />
-          <Map s="Organism|Liver|Vf (protein)-WS" id="1559" />
-          <Map s="Organism|Liver|Vf (water)-WS" id="1560" />
-          <Map s="Organism|Liver|Vf (intracellular water)-RR" id="1561" />
-          <Map s="Organism|Liver|Acidic phospholipids [mg/g] - RR" id="1562" />
-          <Map s="Organism|Liver|Vf (acidic phospholipids)-WS" id="1563" />
-          <Map s="Organism|Liver|Volume|Percentile" id="1564" />
-          <Map s="Organism|Liver|Volume|Mean" id="1565" />
-          <Map s="Organism|Liver|Volume|Deviation" id="1566" />
-          <Map s="Organism|Liver|Specific blood flow rate|Percentile" id="1567" />
-          <Map s="Organism|Liver|Specific blood flow rate|Mean" id="1568" />
-          <Map s="Organism|Liver|Specific blood flow rate|Deviation" id="1569" />
-          <Map s="Organism|Liver|Intracellular|pH" id="1570" />
-          <Map s="Organism|Lung|Allometric scale factor" id="1571" />
-          <Map s="Organism|Lung|Density (tissue)" id="1572" />
-          <Map s="Organism|Lung|Fraction of blood for sampling" id="1573" />
-          <Map s="Organism|Lung|Flow fraction via large pores" id="1574" />
-          <Map s="Organism|Lung|Fluid recirculation flow rate" id="1575" />
-          <Map s="Organism|Lung|Hydraulic conductivity" id="1576" />
-          <Map s="Organism|Lung|Lymph flow rate" id="1577" />
-          <Map s="Organism|Lung|Radius (large pores)" id="1578" />
-          <Map s="Organism|Lung|Radius (small pores)" id="1579" />
-          <Map s="Organism|Lung|Vf (neutral lipid)-PT" id="1580" />
-          <Map s="Organism|Lung|Vf (lipid)" id="1581" />
-          <Map s="Organism|Lung|Vf (protein)" id="1582" />
-          <Map s="Organism|Lung|Vf (phospholipid)-PT" id="1583" />
-          <Map s="Organism|Lung|Lipoprotein ratio (tissue/plasma)" id="1584" />
-          <Map s="Organism|Lung|Vf (water)" id="1585" />
-          <Map s="Organism|Lung|Vf (water)-PT" id="1586" />
-          <Map s="Organism|Lung|Albumin ratio (tissue/plasma)-PT" id="1587" />
-          <Map s="Organism|Lung|Albumin ratio (tissue/plasma)" id="1588" />
-          <Map s="Organism|Lung|Protein mass/g tissue" id="1589" />
-          <Map s="Organism|Lung|Number of cells/g tissue" id="1590" />
-          <Map s="Organism|Lung|Microsomal protein mass/g tissue" id="1591" />
-          <Map s="Organism|Lung|Fraction interstitial" id="1592" />
-          <Map s="Organism|Lung|Vf (neutral lipid)-RR" id="1593" />
-          <Map s="Organism|Lung|Vf (neutral lipid)-WS" id="1594" />
-          <Map s="Organism|Lung|Vf (neutral phospholipid)-RR" id="1595" />
-          <Map s="Organism|Lung|Vf (neutral phospholipid, plasma)-WS" id="1596" />
-          <Map s="Organism|Lung|Vf (protein)-WS" id="1597" />
-          <Map s="Organism|Lung|Vf (extracellular water)-RR" id="1598" />
-          <Map s="Organism|Lung|Vf (intracellular water)-RR" id="1599" />
-          <Map s="Organism|Lung|Vf (water)-WS" id="1600" />
-          <Map s="Organism|Lung|Acidic phospholipids [mg/g] - RR" id="1601" />
-          <Map s="Organism|Lung|Vf (acidic phospholipids)-WS" id="1602" />
-          <Map s="Organism|Lung|Volume|Percentile" id="1603" />
-          <Map s="Organism|Lung|Volume|Mean" id="1604" />
-          <Map s="Organism|Lung|Volume|GeometricDeviation" id="1605" />
-          <Map s="Organism|Lung|Fraction vascular|Percentile" id="1606" />
-          <Map s="Organism|Lung|Fraction vascular|Mean" id="1607" />
-          <Map s="Organism|Lung|Intracellular|pH" id="1608" />
-          <Map s="Organism|Muscle|Allometric scale factor" id="1609" />
-          <Map s="Organism|Muscle|Peripheral blood flow fraction" id="1610" />
-          <Map s="Organism|Muscle|Density (tissue)" id="1611" />
-          <Map s="Organism|Muscle|Fraction of blood for sampling" id="1612" />
-          <Map s="Organism|Muscle|Radius (small pores)" id="1613" />
-          <Map s="Organism|Muscle|Flow fraction via large pores" id="1614" />
-          <Map s="Organism|Muscle|Fluid recirculation flow rate" id="1615" />
-          <Map s="Organism|Muscle|Hydraulic conductivity" id="1616" />
-          <Map s="Organism|Muscle|Radius (large pores)" id="1617" />
-          <Map s="Organism|Muscle|Lymph flow rate" id="1618" />
-          <Map s="Organism|Muscle|Vf (lipid)" id="1619" />
-          <Map s="Organism|Muscle|Vf (neutral lipid)-PT" id="1620" />
-          <Map s="Organism|Muscle|Fraction vascular" id="1621" />
-          <Map s="Organism|Muscle|Vf (phospholipid)-PT" id="1622" />
-          <Map s="Organism|Muscle|Vf (protein)" id="1623" />
-          <Map s="Organism|Muscle|Albumin ratio (tissue/plasma)" id="1624" />
-          <Map s="Organism|Muscle|Vf (water)" id="1625" />
-          <Map s="Organism|Muscle|Albumin ratio (tissue/plasma)-PT" id="1626" />
-          <Map s="Organism|Muscle|Lipoprotein ratio (tissue/plasma)" id="1627" />
-          <Map s="Organism|Muscle|Vf (water)-PT" id="1628" />
-          <Map s="Organism|Muscle|Microsomal protein mass/g tissue" id="1629" />
-          <Map s="Organism|Muscle|Number of cells/g tissue" id="1630" />
-          <Map s="Organism|Muscle|Protein mass/g tissue" id="1631" />
-          <Map s="Organism|Muscle|Vf (neutral lipid)-WS" id="1632" />
-          <Map s="Organism|Muscle|Vf (neutral lipid)-RR" id="1633" />
-          <Map s="Organism|Muscle|Vf (neutral phospholipid, plasma)-WS" id="1634" />
-          <Map s="Organism|Muscle|Vf (neutral phospholipid)-RR" id="1635" />
-          <Map s="Organism|Muscle|Vf (extracellular water)-RR" id="1636" />
-          <Map s="Organism|Muscle|Vf (protein)-WS" id="1637" />
-          <Map s="Organism|Muscle|Vf (water)-WS" id="1638" />
-          <Map s="Organism|Muscle|Vf (intracellular water)-RR" id="1639" />
-          <Map s="Organism|Muscle|Vf (acidic phospholipids)-WS" id="1640" />
-          <Map s="Organism|Muscle|Acidic phospholipids [mg/g] - RR" id="1641" />
-          <Map s="Organism|Muscle|Volume fraction water scale factor|Percentile" id="1642" />
-          <Map s="Organism|Muscle|Volume fraction water scale factor|Mean" id="1643" />
-          <Map s="Organism|Muscle|Volume fraction proteins scale factor|Percentile" id="1644" />
-          <Map s="Organism|Muscle|Volume fraction proteins scale factor|Mean" id="1645" />
-          <Map s="Organism|Muscle|Volume fraction lipids scale factor|Percentile" id="1646" />
-          <Map s="Organism|Muscle|Volume fraction lipids scale factor|Mean" id="1647" />
-          <Map s="Organism|Muscle|Volume|Percentile" id="1648" />
-          <Map s="Organism|Muscle|Volume|Mean" id="1649" />
-          <Map s="Organism|Muscle|Volume|GeometricDeviation" id="1650" />
-          <Map s="Organism|Muscle|Fraction interstitial|Percentile" id="1651" />
-          <Map s="Organism|Muscle|Fraction interstitial|Mean" id="1652" />
-          <Map s="Organism|Muscle|Specific blood flow rate|Percentile" id="1653" />
-          <Map s="Organism|Muscle|Specific blood flow rate|Mean" id="1654" />
-          <Map s="Organism|Muscle|Specific blood flow rate|Deviation" id="1655" />
-          <Map s="Organism|Muscle|Intracellular|pH" id="1656" />
-          <Map s="Organism|Pancreas|Allometric scale factor" id="1657" />
-          <Map s="Organism|Pancreas|Density (tissue)" id="1658" />
-          <Map s="Organism|Pancreas|Fraction of blood for sampling" id="1659" />
-          <Map s="Organism|Pancreas|Hydraulic conductivity" id="1660" />
-          <Map s="Organism|Pancreas|Radius (large pores)" id="1661" />
-          <Map s="Organism|Pancreas|Lymph flow rate" id="1662" />
-          <Map s="Organism|Pancreas|Flow fraction via large pores" id="1663" />
-          <Map s="Organism|Pancreas|Fluid recirculation flow rate" id="1664" />
-          <Map s="Organism|Pancreas|Radius (small pores)" id="1665" />
-          <Map s="Organism|Pancreas|Vf (neutral lipid)-PT" id="1666" />
-          <Map s="Organism|Pancreas|Vf (lipid)" id="1667" />
-          <Map s="Organism|Pancreas|Fraction vascular" id="1668" />
-          <Map s="Organism|Pancreas|Vf (phospholipid)-PT" id="1669" />
-          <Map s="Organism|Pancreas|Vf (protein)" id="1670" />
-          <Map s="Organism|Pancreas|Albumin ratio (tissue/plasma)" id="1671" />
-          <Map s="Organism|Pancreas|Lipoprotein ratio (tissue/plasma)" id="1672" />
-          <Map s="Organism|Pancreas|Albumin ratio (tissue/plasma)-PT" id="1673" />
-          <Map s="Organism|Pancreas|Vf (water)" id="1674" />
-          <Map s="Organism|Pancreas|Vf (water)-PT" id="1675" />
-          <Map s="Organism|Pancreas|Protein mass/g tissue" id="1676" />
-          <Map s="Organism|Pancreas|Number of cells/g tissue" id="1677" />
-          <Map s="Organism|Pancreas|Microsomal protein mass/g tissue" id="1678" />
-          <Map s="Organism|Pancreas|Fraction interstitial" id="1679" />
-          <Map s="Organism|Pancreas|Vf (neutral lipid)-WS" id="1680" />
-          <Map s="Organism|Pancreas|Vf (neutral lipid)-RR" id="1681" />
-          <Map s="Organism|Pancreas|Vf (neutral phospholipid)-RR" id="1682" />
-          <Map s="Organism|Pancreas|Vf (neutral phospholipid, plasma)-WS" id="1683" />
-          <Map s="Organism|Pancreas|Vf (protein)-WS" id="1684" />
-          <Map s="Organism|Pancreas|Vf (extracellular water)-RR" id="1685" />
-          <Map s="Organism|Pancreas|Vf (water)-WS" id="1686" />
-          <Map s="Organism|Pancreas|Vf (intracellular water)-RR" id="1687" />
-          <Map s="Organism|Pancreas|Vf (acidic phospholipids)-WS" id="1688" />
-          <Map s="Organism|Pancreas|Acidic phospholipids [mg/g] - RR" id="1689" />
-          <Map s="Organism|Pancreas|Volume|Percentile" id="1690" />
-          <Map s="Organism|Pancreas|Volume|Mean" id="1691" />
-          <Map s="Organism|Pancreas|Volume|Deviation" id="1692" />
-          <Map s="Organism|Pancreas|Specific blood flow rate|Percentile" id="1693" />
-          <Map s="Organism|Pancreas|Specific blood flow rate|Mean" id="1694" />
-          <Map s="Organism|Pancreas|Specific blood flow rate|Deviation" id="1695" />
-          <Map s="Organism|Pancreas|Intracellular|pH" id="1696" />
-          <Map s="Organism|PortalVein|Allometric scale factor" id="1697" />
-          <Map s="Organism|PortalVein|Density (tissue)" id="1698" />
-          <Map s="Organism|PortalVein|Fraction vascular" id="1699" />
-          <Map s="Organism|PortalVein|Volume|Percentile" id="1700" />
-          <Map s="Organism|PortalVein|Volume|Mean" id="1701" />
-          <Map s="Organism|PortalVein|Volume|Deviation" id="1702" />
-          <Map s="Organism|Skin|Allometric scale factor" id="1703" />
-          <Map s="Organism|Skin|Density (tissue)" id="1704" />
-          <Map s="Organism|Skin|Peripheral blood flow fraction" id="1705" />
-          <Map s="Organism|Skin|Fraction of blood for sampling" id="1706" />
-          <Map s="Organism|Skin|Radius (large pores)" id="1707" />
-          <Map s="Organism|Skin|Radius (small pores)" id="1708" />
-          <Map s="Organism|Skin|Hydraulic conductivity" id="1709" />
-          <Map s="Organism|Skin|Lymph flow rate" id="1710" />
-          <Map s="Organism|Skin|Flow fraction via large pores" id="1711" />
-          <Map s="Organism|Skin|Fluid recirculation flow rate" id="1712" />
-          <Map s="Organism|Skin|Vf (lipid)" id="1713" />
-          <Map s="Organism|Skin|Vf (neutral lipid)-PT" id="1714" />
-          <Map s="Organism|Skin|Fraction vascular" id="1715" />
-          <Map s="Organism|Skin|Vf (protein)" id="1716" />
-          <Map s="Organism|Skin|Vf (phospholipid)-PT" id="1717" />
-          <Map s="Organism|Skin|Albumin ratio (tissue/plasma)-PT" id="1718" />
-          <Map s="Organism|Skin|Vf (water)-PT" id="1719" />
-          <Map s="Organism|Skin|Vf (water)" id="1720" />
-          <Map s="Organism|Skin|Lipoprotein ratio (tissue/plasma)" id="1721" />
-          <Map s="Organism|Skin|Albumin ratio (tissue/plasma)" id="1722" />
-          <Map s="Organism|Skin|Protein mass/g tissue" id="1723" />
-          <Map s="Organism|Skin|Number of cells/g tissue" id="1724" />
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-          <Map s="Organism|Skin|Vf (intracellular water)-RR" id="1733" />
-          <Map s="Organism|Skin|Vf (water)-WS" id="1734" />
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-          <Map s="Organism|Skin|Volume|Percentile" id="1737" />
-          <Map s="Organism|Skin|Volume|Mean" id="1738" />
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-          <Map s="Organism|Skin|Specific blood flow rate|Percentile" id="1740" />
-          <Map s="Organism|Skin|Specific blood flow rate|Mean" id="1741" />
-          <Map s="Organism|Skin|Specific blood flow rate|Deviation" id="1742" />
-          <Map s="Organism|Skin|Intracellular|pH" id="1743" />
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-          <Map s="Organism|Spleen|Fluid recirculation flow rate" id="1751" />
-          <Map s="Organism|Spleen|Flow fraction via large pores" id="1752" />
-          <Map s="Organism|Spleen|Vf (lipid)" id="1753" />
-          <Map s="Organism|Spleen|Vf (neutral lipid)-PT" id="1754" />
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-          <Map s="Organism|Spleen|Vf (protein)" id="1756" />
-          <Map s="Organism|Spleen|Vf (phospholipid)-PT" id="1757" />
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-          <Map s="Organism|Spleen|Albumin ratio (tissue/plasma)" id="1761" />
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-          <Map s="Organism|Fat|Plasma" id="13" />
-          <Map s="Organism|Fat|BloodCells" id="14" />
-          <Map s="Organism|Fat|Interstitial" id="15" />
-          <Map s="Organism|Fat|Intracellular" id="16" />
-          <Map s="Organism|Gonads|Plasma" id="17" />
-          <Map s="Organism|Gonads|BloodCells" id="18" />
-          <Map s="Organism|Gonads|Interstitial" id="19" />
-          <Map s="Organism|Gonads|Intracellular" id="20" />
-          <Map s="Organism|Heart|Plasma" id="21" />
-          <Map s="Organism|Heart|BloodCells" id="22" />
-          <Map s="Organism|Heart|Interstitial" id="23" />
-          <Map s="Organism|Heart|Intracellular" id="24" />
-          <Map s="Organism|Kidney|Plasma" id="25" />
-          <Map s="Organism|Kidney|BloodCells" id="26" />
-          <Map s="Organism|Kidney|Interstitial" id="27" />
-          <Map s="Organism|Kidney|Intracellular" id="28" />
-          <Map s="Organism|Kidney|Urine" id="29" />
-          <Map s="Organism|Lumen|Stomach" id="30" />
-          <Map s="Organism|Lumen|Duodenum" id="31" />
-          <Map s="Organism|Lumen|UpperJejunum" id="32" />
-          <Map s="Organism|Lumen|LowerJejunum" id="33" />
-          <Map s="Organism|Lumen|UpperIleum" id="34" />
-          <Map s="Organism|Lumen|LowerIleum" id="35" />
-          <Map s="Organism|Lumen|Caecum" id="36" />
-          <Map s="Organism|Lumen|ColonAscendens" id="37" />
-          <Map s="Organism|Lumen|ColonTransversum" id="38" />
-          <Map s="Organism|Lumen|ColonDescendens" id="39" />
-          <Map s="Organism|Lumen|ColonSigmoid" id="40" />
-          <Map s="Organism|Lumen|Rectum" id="41" />
-          <Map s="Organism|Lumen|Feces" id="42" />
-          <Map s="Organism|Stomach|Plasma" id="43" />
-          <Map s="Organism|Stomach|BloodCells" id="44" />
-          <Map s="Organism|Stomach|Interstitial" id="45" />
-          <Map s="Organism|Stomach|Intracellular" id="46" />
-          <Map s="Organism|SmallIntestine|Plasma" id="47" />
-          <Map s="Organism|SmallIntestine|BloodCells" id="48" />
-          <Map s="Organism|SmallIntestine|Interstitial" id="49" />
-          <Map s="Organism|SmallIntestine|Intracellular" id="50" />
-          <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Plasma" id="51" />
-          <Map s="Organism|SmallIntestine|Mucosa|Duodenum|BloodCells" id="52" />
-          <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Interstitial" id="53" />
-          <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Intracellular" id="54" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Plasma" id="55" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|BloodCells" id="56" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Interstitial" id="57" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular" id="58" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Plasma" id="59" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|BloodCells" id="60" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Interstitial" id="61" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular" id="62" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Plasma" id="63" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|BloodCells" id="64" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Interstitial" id="65" />
-          <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular" id="66" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Plasma" id="67" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|BloodCells" id="68" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Interstitial" id="69" />
-          <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular" id="70" />
-          <Map s="Organism|LargeIntestine|Plasma" id="71" />
-          <Map s="Organism|LargeIntestine|BloodCells" id="72" />
-          <Map s="Organism|LargeIntestine|Interstitial" id="73" />
-          <Map s="Organism|LargeIntestine|Intracellular" id="74" />
-          <Map s="Organism|LargeIntestine|Mucosa|Caecum|Plasma" id="75" />
-          <Map s="Organism|LargeIntestine|Mucosa|Caecum|BloodCells" id="76" />
-          <Map s="Organism|LargeIntestine|Mucosa|Caecum|Interstitial" id="77" />
-          <Map s="Organism|LargeIntestine|Mucosa|Caecum|Intracellular" id="78" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonAscendens|Plasma" id="79" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonAscendens|BloodCells" id="80" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonAscendens|Interstitial" id="81" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular" id="82" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonTransversum|Plasma" id="83" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonTransversum|BloodCells" id="84" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonTransversum|Interstitial" id="85" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular" id="86" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonDescendens|Plasma" id="87" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonDescendens|BloodCells" id="88" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonDescendens|Interstitial" id="89" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular" id="90" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonSigmoid|Plasma" id="91" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonSigmoid|BloodCells" id="92" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonSigmoid|Interstitial" id="93" />
-          <Map s="Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular" id="94" />
-          <Map s="Organism|LargeIntestine|Mucosa|Rectum|Plasma" id="95" />
-          <Map s="Organism|LargeIntestine|Mucosa|Rectum|BloodCells" id="96" />
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-          <Map s="Organism|LargeIntestine|Mucosa|Rectum|Intracellular" id="98" />
-          <Map s="Organism|Liver|Plasma" id="99" />
-          <Map s="Organism|Liver|BloodCells" id="100" />
-          <Map s="Organism|Liver|Interstitial" id="101" />
-          <Map s="Organism|Liver|Intracellular" id="102" />
-          <Map s="Organism|Lung|Plasma" id="103" />
-          <Map s="Organism|Lung|BloodCells" id="104" />
-          <Map s="Organism|Lung|Interstitial" id="105" />
-          <Map s="Organism|Lung|Intracellular" id="106" />
-          <Map s="Organism|Muscle|Plasma" id="107" />
-          <Map s="Organism|Muscle|BloodCells" id="108" />
-          <Map s="Organism|Muscle|Interstitial" id="109" />
-          <Map s="Organism|Muscle|Intracellular" id="110" />
-          <Map s="Organism|Pancreas|Plasma" id="111" />
-          <Map s="Organism|Pancreas|BloodCells" id="112" />
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-          <Map s="Organism|Pancreas|Intracellular" id="114" />
-          <Map s="Organism|PortalVein|Plasma" id="115" />
-          <Map s="Organism|PortalVein|BloodCells" id="116" />
-          <Map s="Organism|Skin|Plasma" id="117" />
-          <Map s="Organism|Skin|BloodCells" id="118" />
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-          <Map s="Organism|Spleen|BloodCells" id="122" />
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-          <Map s="Organism|Spleen|Intracellular" id="124" />
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-    <AllCalculationMethods>
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-                <Path path="16" as="17" />
-                <Path path="18" as="19" />
-              </Paths>
-            </Formula>
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-                </DescriptorConditions>
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-            <Map s="fu" id="1" />
-            <Map s="Fraction" id="2" />
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-            <Map s="LogMA" id="4" />
-            <Map s="Lipophilicity" id="5" />
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-            <Map s="Organism|Vf (lipid, blood cells)" id="8" />
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-            <Map s="Organism|Vf (protein,blood cells)" id="10" />
-            <Map s="f_proteins_rbc" id="11" />
-            <Map s="Organism|Vf (water,blood cells)" id="12" />
-            <Map s="f_water_rbc" id="13" />
-            <Map s="FIRST_NEIGHBOR|..|Vf (lipid)" id="14" />
-            <Map s="f_lipids" id="15" />
-            <Map s="FIRST_NEIGHBOR|..|Vf (protein)" id="16" />
-            <Map s="f_proteins" id="17" />
-            <Map s="FIRST_NEIGHBOR|..|Vf (water)" id="18" />
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-      </CoreCalculationMethod>
-      <CoreCalculationMethod name="Cellular permeability - PK-Sim Standard" category="DiffusionIntCell">
-        <OutputFormulas>
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-                </DescriptorConditions>
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-        <HelpParameters />
-        <FormulaCache>
-          <StringMap />
-        </FormulaCache>
-      </CoreCalculationMethod>
-      <CoreCalculationMethod name="Interstitial partition coefficient method - Schmitt" category="DistributionInterstitial">
-        <OutputFormulas>
-          <KeyValue>
-            <Formula id="Interstitial partition coefficient method - Schmitt.PARAM_K_int_pls" name="PARAM_K_int_pls" dim="Dimensionless" formula="(f_water_int + f_proteins_int_to_pls * (1/fu - f_water_pls)) * fu">
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-                <Path path="3" as="4" />
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-                <Path path="7" as="8" />
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-                  <MatchTagCondition tag="Neighborhood: Plasma / Interstitial" />
-                </DescriptorConditions>
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-          <KeyValue>
-            <ConstantFormula id="bTEX-0ooiE2ADJ0nTEKECQ" dim="Dimensionless" value="1" />
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-                  <MatchTagCondition tag="EndogenousIgG_int_EndogenousIgG_pls" />
-                </DescriptorConditions>
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-        <HelpParameters>
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-            <Parameter id="dJxp7vggzUKDOO4GTDsQww" name="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" formula="Interstitial partition coefficient method - Schmitt.PARAM_K_water_int_bon_Schmitt" dim="Dimensionless" quantityType="0" />
-            <DescriptorCriteria>
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-            <DescriptorCriteria>
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-            <DescriptorCriteria>
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-                <MatchTagCondition tag="Heart_int_Heart_cell" />
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-            <DescriptorCriteria>
-              <DescriptorConditions>
-                <MatchTagCondition tag="Kidney_int_Kidney_cell" />
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-            <DescriptorCriteria>
-              <DescriptorConditions>
-                <MatchTagCondition tag="Large intestine  neighborhood" />
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-              </DescriptorConditions>
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-          <KeyValue>
-            <Parameter id="k_ME0o3BckKd2GqIKj9H3A" name="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" formula="Interstitial partition coefficient method - Schmitt.PARAM_K_water_int_liv_Schmitt" dim="Dimensionless" quantityType="0" />
-            <DescriptorCriteria>
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-                <MatchTagCondition tag="Liver_int_Liver_cell" />
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-            <DescriptorCriteria>
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-            <DescriptorCriteria>
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-                <MatchTagCondition tag="Pancreas_int_Pancreas_cell" />
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-            <Formula id="Interstitial partition coefficient method - Schmitt.PARAM_K_water_int_fat_Schmitt" name="PARAM_K_water_int_fat_Schmitt" dim="Dimensionless" formula="fu/K_int_pls">
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-            </Formula>
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-              <Paths>
-                <Path path="0" as="1" dim="2" />
-                <Path path="14" as="10" />
-              </Paths>
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-              <Paths>
-                <Path path="0" as="1" dim="2" />
-                <Path path="15" as="10" />
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-            </Formula>
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-              <Paths>
-                <Path path="0" as="1" dim="2" />
-                <Path path="16" as="10" />
-              </Paths>
-            </Formula>
-            <Formula id="Interstitial partition coefficient method - Schmitt.PARAM_K_water_int_lng_Schmitt" name="PARAM_K_water_int_lng_Schmitt" dim="Dimensionless" formula="fu/K_int_pls">
-              <Paths>
-                <Path path="0" as="1" dim="2" />
-                <Path path="17" as="10" />
-              </Paths>
-            </Formula>
-            <Formula id="Interstitial partition coefficient method - Schmitt.PARAM_K_water_int_mus_Schmitt" name="PARAM_K_water_int_mus_Schmitt" dim="Dimensionless" formula="fu/K_int_pls">
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-                <Path path="0" as="1" dim="2" />
-                <Path path="18" as="10" />
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-            <Formula id="Interstitial partition coefficient method - Schmitt.PARAM_K_water_int_pan_Schmitt" name="PARAM_K_water_int_pan_Schmitt" dim="Dimensionless" formula="fu/K_int_pls">
-              <Paths>
-                <Path path="0" as="1" dim="2" />
-                <Path path="19" as="10" />
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-            <Formula id="Interstitial partition coefficient method - Schmitt.PARAM_K_water_int_sin_Schmitt" name="PARAM_K_water_int_sin_Schmitt" dim="Dimensionless" formula="fu/K_int_pls">
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-                <Path path="20" as="10" />
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-            <Formula id="Interstitial partition coefficient method - Schmitt.PARAM_K_water_int_skn_Schmitt" name="PARAM_K_water_int_skn_Schmitt" dim="Dimensionless" formula="fu/K_int_pls">
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-                <Path path="21" as="10" />
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-            <Formula id="Interstitial partition coefficient method - Schmitt.PARAM_K_water_int_spl_Schmitt" name="PARAM_K_water_int_spl_Schmitt" dim="Dimensionless" formula="fu/K_int_pls">
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-                <Path path="22" as="10" />
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-            <Formula id="Interstitial partition coefficient method - Schmitt.PARAM_K_water_int_sto_Schmitt" name="PARAM_K_water_int_sto_Schmitt" dim="Dimensionless" formula="fu/K_int_pls">
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-                <Path path="23" as="10" />
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-          <StringMap>
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-            <Map s="fu" id="1" />
-            <Map s="Fraction" id="2" />
-            <Map s="Organism|Protein ratio (interstial/plasma)" id="3" />
-            <Map s="f_proteins_int_to_pls" id="4" />
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-            <Map s="f_water_int" id="6" />
-            <Map s="Organism|Vf (water,plasma)" id="7" />
-            <Map s="f_water_pls" id="8" />
-            <Map s="Neighborhoods|Bone_pls_Bone_int|MOLECULE|Partition coefficient (interstitial/plasma)" id="9" />
-            <Map s="K_int_pls" id="10" />
-            <Map s="Neighborhoods|Brain_pls_Brain_int|MOLECULE|Partition coefficient (interstitial/plasma)" id="11" />
-            <Map s="Neighborhoods|Fat_pls_Fat_int|MOLECULE|Partition coefficient (interstitial/plasma)" id="12" />
-            <Map s="Neighborhoods|Heart_pls_Heart_int|MOLECULE|Partition coefficient (interstitial/plasma)" id="13" />
-            <Map s="Neighborhoods|Kidney_pls_Kidney_int|MOLECULE|Partition coefficient (interstitial/plasma)" id="14" />
-            <Map s="Neighborhoods|LargeIntestine_pls_LargeIntestine_int|MOLECULE|Partition coefficient (interstitial/plasma)" id="15" />
-            <Map s="Neighborhoods|Liver_pls_Liver_int|MOLECULE|Partition coefficient (interstitial/plasma)" id="16" />
-            <Map s="Neighborhoods|Lung_pls_Lung_int|MOLECULE|Partition coefficient (interstitial/plasma)" id="17" />
-            <Map s="Neighborhoods|Muscle_pls_Muscle_int|MOLECULE|Partition coefficient (interstitial/plasma)" id="18" />
-            <Map s="Neighborhoods|Pancreas_pls_Pancreas_int|MOLECULE|Partition coefficient (interstitial/plasma)" id="19" />
-            <Map s="Neighborhoods|SmallIntestine_pls_SmallIntestine_int|MOLECULE|Partition coefficient (interstitial/plasma)" id="20" />
-            <Map s="Neighborhoods|Skin_pls_Skin_int|MOLECULE|Partition coefficient (interstitial/plasma)" id="21" />
-            <Map s="Neighborhoods|Spleen_pls_Spleen_int|MOLECULE|Partition coefficient (interstitial/plasma)" id="22" />
-            <Map s="Neighborhoods|Stomach_pls_Stomach_int|MOLECULE|Partition coefficient (interstitial/plasma)" id="23" />
-            <Map s="Neighborhoods|Gonads_pls_Gonads_int|MOLECULE|Partition coefficient (interstitial/plasma)" id="24" />
-          </StringMap>
-        </FormulaCache>
-      </CoreCalculationMethod>
-    </AllCalculationMethods>
-  </BuildConfiguration>
-  <SimulationConfiguration randomSeed="1">
-    <CVODESettings solverName="CVODE1002_2" absTol="1E-09" relTol="0.0001" h0="1E-10" hMax="60" hMin="0" mxStep="100000" useJacobian="1" dynamicName="Solver" />
-    <OutputSchema>
-      <Intervals>
-        <OutputInterval startTime="0" endTime="1440" resolution="4" />
-      </Intervals>
-    </OutputSchema>
-  </SimulationConfiguration>
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-      <Tags>
-        <Tag value="RootContainer" />
-      </Tags>
-      <Children>
-        <Container id="cij_7OaR6keNqytPsNfsow" name="Organism" description="Organism" icon="Organism" mode="Logical" containerType="Organism">
-          <Tags>
-            <Tag value="Organism" />
-          </Tags>
-          <Children>
-            <Parameter id="tLVPssv2lkSSjQI3q3cYrA" name="BMI" description="Body mass index" persistable="0" isFixedValue="0" formula="Qb7nQ3HRT0Ce_cS3ciSIZg" dim="BMI" quantityType="0" />
-            <Parameter id="5ogoqVQU5E6sxHmPPjuSKQ" name="Weight" description="Body weight" persistable="0" isFixedValue="0" formula="tSobV-ANhE6XfXxMiDroBw" dim="Mass" quantityType="0" />
-            <Parameter id="yNRl2RUpaUCgji3NQNlb9w" name="Volume (plasma)" description="Whole body plasma volume" persistable="0" isFixedValue="0" formula="DS1ik1gi-ku0dD95TvEB1Q" dim="Volume" quantityType="0" />
-            <Parameter id="aoR7uJ2rZUep1cE_BEEcSg" name="Estimated gestational age" description="Estimated gestational age" persistable="0" isFixedValue="0" formula="p7nX_wgFY0SMhFsdWkKBUA" dim="AgeInWeeks" quantityType="0" />
-            <Parameter id="ro2ZjcWSy0OmH5NXKp-3-Q" name="Surface area scaling exponent" description="Global shape parameter; used (as exponent) for calculating diffusion stream between plasma and interstitial space" persistable="0" isFixedValue="0" formula="V-_Btes0hEWyOE5vW_LC3w" dim="Dimensionless" quantityType="0" />
-            <Parameter id="Y_R-_BZ5mEm2KRf6sK3wog" name="SA proportionality factor" description="Proportionality factor for the surface area plasma &lt;=&gt; int" persistable="0" isFixedValue="0" formula="7SEvxzmn_UisboTs_-_8Jg" dim="Dimensionless" quantityType="0" />
-            <Parameter id="X5iibcdUI02gneZ-RXOJ_w" name="Specific clearance (endosome)" description="Specific endosomal clearance" persistable="0" isFixedValue="0" formula="UcTkWtzk2EiVNhBp6pSkqA" dim="InversedTime" quantityType="0" />
-            <Parameter id="Us_o1cOC4UaTeNPnHxwpxg" name="Vf (lipid, blood cells)" description="Fractional volume content of lipid in blood cells" persistable="0" isFixedValue="0" formula="13VFSKS6fkqYTHb-K9Gmig" dim="Dimensionless" quantityType="0" />
-            <Parameter id="pQkqBhG2D0O31wxK7NOrkQ" name="Vf (water,blood cells)" description="Fractional volume content of water in blood cells used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="hxDG8cWMj0iBWWd1FM0-GA" dim="Dimensionless" quantityType="0" />
-            <Parameter id="mBIbZj87yEC-Xa86pryyjA" name="FcRn receptor conc. (endosome)" description="Concentration of FcRn receptor in endosomal space" persistable="0" isFixedValue="0" formula="xuxL0ZG_PUK1XJlEhn-hPQ" dim="MolarConcentration" quantityType="0" />
-            <Parameter id="EXrSUBoxhUqohVbwpUUHpw" name="Vf (water,interstitial)" description="Fractional volume content of water in interstitial space used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="8HCiXLyBukyQzUGPd4wx3A" dim="Dimensionless" quantityType="0" />
-            <Parameter id="erWlIeT7A0eieQBp4N9JAw" name="Protein ratio (interstial/plasma)" description="The ratio between the protein volume fraction in interstitial space and plasma" persistable="0" isFixedValue="0" formula="HdOaifbTJUy04E4buH5LdQ" dim="Dimensionless" quantityType="0" />
-            <Parameter id="TMwfty8aCUSiDvXrTwC--Q" name="Vf (protein,plasma)" description="Fractional volume content of protein in plasma used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="IjeJ3naoFk20BBG23N89KA" dim="Dimensionless" quantityType="0" />
-            <Parameter id="I7wco6UkS0O9tkT_p2EyYQ" name="Vf (protein,blood cells)" description="Fractional volume content of protein in blood cells used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="J2iC-FnYvki8l5dvbJqTZg" dim="Dimensionless" quantityType="0" />
-            <Parameter id="Exskc9hDZEWZQLmMwtRTMA" name="Vf (neutral lipid, plasma)-RR" description="Fractional volume content of neutral lipid in plasma used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="3YEu9s94a0Ct5hElJk_-VQ" dim="Dimensionless" quantityType="0" />
-            <Parameter id="LJn9Chg-xUWo9iY9PWe0Lg" name="Vf (neutral lipid, blood cells)-WS" description="Fractional volume content of neutral lipid in blood cells used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="rhbDYbnbu0e7gYRjF00Leg" dim="Dimensionless" quantityType="0" />
-            <Parameter id="Lk6wmkJudEmcoipm4SYO-w" name="Vf (lipid, plasma)" description="Fractional volume content of lipid in plasma" persistable="0" isFixedValue="0" formula="8_5pImpbLkCE6L6UiG1ZKQ" dim="Dimensionless" quantityType="0" />
-            <Parameter id="66ImO_F8REuLtgvBUC1bUQ" name="Vf (water,plasma)" description="Fractional volume content of water in plasma used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="10R0xygA2UWc7EYaOWtifw" dim="Dimensionless" quantityType="0" />
-            <Parameter id="5xYjh-zlYE61uc0UJyeu8w" name="Na" description="Avogadro constant" persistable="0" isFixedValue="0" formula="27cHQkLHi0ekmY4V1IBdXA" dim="InversedMol" quantityType="0" />
-            <Parameter id="NsJQWDC-mUeYFyctPEM05g" name="R*T" description="Gas constant-body temperature product (37°C)" persistable="0" isFixedValue="0" formula="eLsbfkotJk6t0Clcrwx_mA" dim="RT" quantityType="0" />
-            <Parameter id="tvVrBdT9jUSrSE_gyVfUEw" name="Age" description="Age" persistable="0" isFixedValue="0" formula="iOWUgNVJ3EaXI6ddQNmLQg" dim="Age" quantityType="0" />
-            <Parameter id="ngvsDf9nDU2ecwG4olp2Ow" name="Rate constant for recycling from endosomal space (global)" description="Rate constant for recycling from endosomal space for all organs" persistable="0" isFixedValue="0" formula="VPVNFI4i_UazEChbTcY1Ag" dim="InversedTime" quantityType="0" />
-            <Parameter id="khyKQcGzcUmUQ9pGuS3x8Q" name="Rate constant for endosomal uptake (global)" description="Rate constant for endosomal uptake for all organs" persistable="0" isFixedValue="0" formula="TyL-ZugB-kGMVX-xPAkGCQ" dim="InversedTime" quantityType="0" />
-            <Parameter id="m9a9mGRsQU6wUonmRkUG8A" name="Fraction recycled to plasma (global)" description="Fraction of recycled drug to plasma relative to recycling to interstitial space" persistable="0" isFixedValue="0" formula="uIcu9annHUiez192r9i0BA" dim="Fraction" quantityType="0" />
-            <Parameter id="l01JRszk8UuyQeSCwxCyDw" name="Fraction of endosomal uptake from plasma (global)" description="Fraction of drug uptake from plasma into endosomal space relative to uptake from interstitial space" persistable="0" isFixedValue="0" formula="DUYMUUL4u0mchx-otCnBvg" dim="Fraction" quantityType="0" />
-            <Parameter id="aJQljUYnLUKovvWQNwqKFg" name="Surface/Volume ratio (blood cells)" description="Surface area to volume ratio of blood cells" persistable="0" isFixedValue="0" formula="Gj05bOM_cEWpWf17oU5MZw" dim="Dimensionless" quantityType="0" />
-            <Parameter id="L4WCI_-xFkqKwTSx6ZRKrA" name="pH (blood cells)" description="Intracellular pH of blood cells" persistable="0" isFixedValue="0" formula="E7JR9fIs-kKTbx0R0UrDZA" dim="Dimensionless" quantityType="0" />
-            <Parameter id="rd1wsDcOqECxySAK1igaOg" name="pH (interstitial)" description="pH of interstitial space" persistable="0" isFixedValue="0" formula="3wWnDpvlH0uijYHJ-GBubA" dim="Dimensionless" quantityType="0" />
-            <Parameter id="KM73um9us0mSMAyVTY_YGw" name="pH (intracellular)" description="pH of intracellular space" persistable="0" isFixedValue="0" formula="hS74zpjdskqPYEJKyk4Q8w" dim="Dimensionless" quantityType="0" />
-            <Parameter id="4OppTLFLokOISPsNfsmDaQ" name="pH (plasma)" description="pH of plasma" persistable="0" isFixedValue="0" formula="68pH81q4YUOWvgvd_SQ2bA" dim="Dimensionless" quantityType="0" />
-            <Parameter id="MRTFZ_FAE06D96y2xmSUVQ" name="Thickness (endothelium)" description="Thickness of vascular endothelium" persistable="0" isFixedValue="0" formula="kFZF42Csn0a7H5QvBqcIwA" dim="Length" quantityType="0" />
-            <Parameter id="eIGl2OML10mS3EzfN1A4aw" name="Height" description="Body height" persistable="0" isFixedValue="0" formula="CbNrs_DUVk6vIFVKyeAWvA" dim="Length" quantityType="0" />
-            <Parameter id="06UtdFxxykGLa4PEm4kRIA" name="Fraction endosomal (global)" description="Fraction of endosomal space in vascular endothelium" persistable="0" isFixedValue="0" formula="wsFUlhrzkkqzzwIZC_5lPQ" dim="Fraction" quantityType="0" />
-            <Parameter id="ZgRA9k2R5k2_YDgrTpaOwA" name="Vf (neutral phospholipid, blood cells)-WS" description="Fractional volume content of neutral phospholipid in blood cells used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="3q5kHaPEo0q9AMKrZr6nyQ" dim="Dimensionless" quantityType="0" />
-            <Parameter id="jiUrSY_OZ0aK2XU1EmYKYw" name="Vf (neutral lipid, plasma)-PT" description="Fractional volume content of neutral lipid in plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="CJ3dOEdxFEWlWs2OkCUmgw" dim="Dimensionless" quantityType="0" />
-            <Parameter id="Xa7lacNkYEuFWNhSKisFQw" name="Vf (neutral phospholipid, plasma)-RR" description="Fractional volume content of neutral phospholipid in plasma used in ithe partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="PPVClU9EH02ING5KpW_oEg" dim="Dimensionless" quantityType="0" />
-            <Parameter id="Np-ABorB6kG0N1ostvzKAw" name="Vf (acidic phospholipids, blood cells)-WS" description="Fractional volume content of acidic phospholipid in blood cells used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="YhI5DUMRbkaMqaMXX4M6kw" dim="Dimensionless" quantityType="0" />
-            <Parameter id="tPhV8osoeEyGJTVS3ijWNg" name="Vf (phospholipid, plasma)-PT" description="Fractional volume content of phospholipid in plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="eDn4BMOlJkSyGQO3LAjy5Q" dim="Dimensionless" quantityType="0" />
-            <Parameter id="SaHe7aKLxkuYDWPBZPLh5g" name="Vf (neutral lipid, blood cells)-RR" description="Fractional volume content of neutral lipid in blood cells used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="8ZQFEKwAAUCFzCC9yN4RaA" dim="Dimensionless" quantityType="0" />
-            <Parameter id="vTX4jJ3Gvku-jH2x1MjyBA" name="Vf (neutral phospholipid, blood cells)-RR" description="Fractional volume content of neutral phospholipid in blood cells used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="SWDK3by0v0-T1R6ywfOHuw" dim="Dimensionless" quantityType="0" />
-            <Parameter id="4mw_qTIX6U-hCM_8jb5pJw" name="Vf (water,plasma)-PT" description="Fractional volume content of water in plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="J5BqF13ROk-h_uod9aVB4g" dim="Dimensionless" quantityType="0" />
-            <Parameter id="I7nHTC4OeU29_21ur-OuZA" name="Acidic phospholipids (blood cells) [mg/g] - RR" description="Concentration of acidic phospholipids in red blood cells [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="7Goz49Zdc0eLhVOlTZmuOw" dim="Dimensionless" quantityType="0" />
-            <Parameter id="st3IJGHpNkeKVjpYedkmjg" name="Vf (intracellular water, blood cells)-RR" description="Fractional volume content of intracellular water in blood cells used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="di4d_VZNlUuxeeSXpxSBGw" dim="Dimensionless" quantityType="0" />
-            <DistributedParameter id="VuVucrANbkqL0-zvVi4L4w" name="MeanBW" description="Weight" persistable="1" isFixedValue="0" formula="L0yHOrE5oUyXWMEPzomJPg" dim="Mass" quantityType="0" mode="Logical">
-              <Children>
-                <Parameter id="Edve1aYZGE6_H4_oD4HYFg" name="Percentile" persistable="0" isFixedValue="0" formula="mdK99lBxYE-hgjVvASWNXg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="QRen1_XbIECjphCi9Da0aA" name="Mean" persistable="0" isFixedValue="0" formula="ktpNMGCEEU-f7oNajCpcEQ" dim="Mass" quantityType="0" />
-                <Parameter id="XzARtLmPnUyvwezjSci7cw" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" formula="aWeHNQX0-E28RvNTuSdZ1g" dim="Mass" quantityType="0" />
-              </Children>
-            </DistributedParameter>
-            <DistributedParameter id="S7wzwadvmk-lja5F7nvdBQ" name="MeanHeight" description="Height" persistable="1" isFixedValue="0" formula="OqTvyCjDNkSgeJsg4KqVQA" dim="Length" quantityType="0" mode="Logical">
-              <Children>
-                <Parameter id="7uIcalN8HUSklSnXm7wvFA" name="Percentile" persistable="0" isFixedValue="0" formula="bbTPvi1yNkeXZvkyM1y28g" dim="Dimensionless" quantityType="0" />
-                <Parameter id="MF8lhvGhwEGGWcAn5I2JPg" name="Mean" persistable="0" isFixedValue="0" formula="k9sraA3TnEuzzzXFA7t7wQ" dim="Length" quantityType="0" />
-                <Parameter id="IeHBIiY9AEiWztqYf_7imw" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" formula="G0cAN8GVCkq7XO1CHJUSeg" dim="Length" quantityType="0" />
-              </Children>
-            </DistributedParameter>
-            <DistributedParameter id="KNFLpPoL006-LulzurGPLQ" name="Hematocrit" description="Hematocrit" persistable="1" isFixedValue="0" formula="qN0tUAB1KkynLaS7VqIesw" dim="Dimensionless" quantityType="0" mode="Logical">
-              <Children>
-                <Parameter id="hmGP0a0r9kCrkVUVDj9rdw" name="Percentile" persistable="0" isFixedValue="0" formula="1HuvXT9OaUqoQmAU4bffZA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="wVH4M0an_kyHF5bdBWFoLQ" name="Mean" persistable="0" isFixedValue="0" formula="_bkySkTZdkOeKbbU904gOA" dim="Dimensionless" quantityType="0" />
-              </Children>
-            </DistributedParameter>
-            <Container id="Xkw8N5-HQUeUdcvqp57_YQ" name="PeripheralVenousBlood" description="Peripheral Venous Blood" icon="VenousBlood" mode="Logical" containerType="Organ">
-              <Tags>
-                <Tag value="PeripheralVenousBlood" />
-              </Tags>
-              <Children>
-                <Parameter id="ASHVAgN6iUiUD5DGyv4uhg" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" formula="icbbyklmQk2Mnr47obVHPg" dim="Density" quantityType="0" />
-                <Container id="7aI-DtxY0UuZe6wE5BIT9A" name="Drug" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Observer id="4xQ5yK0mn0-Zyv60wGszaQ" name="Blood Cells" description="Blood Cells" persistable="1" isFixedValue="0" formula="FyCzENPEbU25yIsk0h0FDg" dim="MolarConcentration" quantityType="Drug, Observer" />
-                    <Observer id="gRExZ3wC2UiZSGqxIyp3Rw" name="Plasma (Peripheral Venous Blood)" description="Plasma" persistable="1" isFixedValue="0" formula="JbiXq2O5AUKsCnUrPGbOCA" dim="MolarConcentration" quantityType="Drug, Observer" />
-                    <Observer id="Ykelqvai7ES5HbtGyM0BRg" name="Plasma Unbound (Peripheral Venous Blood)" description="Plasma Unbound" persistable="1" isFixedValue="0" formula="YMuMI4-M70GieeCLhTpfbw" dim="MolarConcentration" quantityType="Drug, Observer" />
-                    <Observer id="MLuzVv61QUu-DRnhrcUf7A" name="Whole Blood (Peripheral Venous Blood)" description="Whole Blood" persistable="1" isFixedValue="0" formula="FSTBIhvvjEKgWC6RPUgdfA" dim="MolarConcentration" quantityType="Drug, Observer" />
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-                    <Parameter id="4iSy4QDUVEO_3GNHWCnZXg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="FhG3giE_-ESA40myfZN-IA" dim="Volume" quantityType="0" />
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-                        <Parameter id="poalOhNLrUiBHkZZbrC-6A" name="Relative expression" description="Relative expression" persistable="0" isFixedValue="0" formula="_J3C13ewoUatoCS2w-zxeg" dim="Fraction" quantityType="0" />
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-                <Tag value="BloodOrgan" />
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-                <Parameter id="_kZ9Ma8qS0u9REh3QogSUQ" name="Peripheral blood flow fraction" description="Blood flow fraction in organ used for calculation of peripheral venous blood concentrations" persistable="0" isFixedValue="0" formula="mzC08kOdW0WC0QwDRK0PcA" dim="Fraction" quantityType="0" />
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-                  <Tags>
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-                    <Tag value="ArterialBlood" />
-                    <Tag value="BloodOrgan" />
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-                    <Parameter id="hbL_zIJA_EqtMH1jBLwXBA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="owgI66XQcE2ClB4BHV50ew" dim="Volume" quantityType="0" />
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-                      <Children>
-                        <Parameter id="u8vX4NYd50aT5qBDDHPzWg" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" formula="nxMIMqgYGEOgHHuOAXryWQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="JfTxWgVZjUWGBDMuDcJL8g" name="Relative expression out." description="Relative Expression that will be used in the simulation" persistable="0" isFixedValue="0" formula="GtBZCb_uvUKgURPKDkyZKA" dim="Fraction" quantityType="0" />
-                        <Parameter id="1Obuy2rNK0yUoqr-aoQcrQ" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" persistable="0" isFixedValue="0" formula="FTxLv_b4CkKigLwWdcA4xg" dim="Fraction" quantityType="0" />
-                        <Parameter id="w-vdEqq-5kaBlB9z2_8apQ" name="Relative expression" description="Relative expression" persistable="0" isFixedValue="0" formula="_J3C13ewoUatoCS2w-zxeg" dim="Fraction" quantityType="0" />
-                        <Parameter id="u5-dZtsip0Oh_LZuSH9NBg" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Observer id="SCboAKR8QkCeP7rBZcpqRQ" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Enzyme, Observer" />
-                      </Children>
-                    </MoleculeAmount>
-                    <MoleculeAmount id="O8XBrIIVPEqaQZSn9t_uuw" name="Drug-Cyp Metabolite" persistable="0" isFixedValue="0" formula="pQhBjq_0Q0ObPZ2tgyWb2Q" dim="Amount" quantityType="Metabolite" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="TRdG6xpTRUCoqsouhq9Jhw" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Observer id="PiI8fcNUGUS0wyo7N1ormw" name="Fraction of dose" description="Metabolized fraction of administered dose" persistable="1" isFixedValue="0" formula="aUoTQ3n3a0OShljd8bUj3w" dim="Fraction" quantityType="Metabolite, Observer" />
-                      </Children>
-                    </MoleculeAmount>
-                    <Reaction id="9S5Iy9j79UyNesw00ICiag" name="Cyp-ME" icon="Metabolism" mode="Logical" containerType="Other" dimension="Dimensionless" formula="NrKgrsKmwkiGET1q7OIPYg">
-                      <Educts>
-                        <ReactionPartner stoichiometricCoefficient="1" partner="KoF_gPV3a0C8KDxsooKTTQ" />
-                      </Educts>
-                      <Products>
-                        <ReactionPartner stoichiometricCoefficient="1" partner="O8XBrIIVPEqaQZSn9t_uuw" />
-                      </Products>
-                      <ModifierNames>
-                        <ModifierNamesChild>Cyp</ModifierNamesChild>
-                      </ModifierNames>
-                    </Reaction>
-                  </Children>
-                </Container>
-                <Container id="H6eUvLBjvkSveDPHiXPWGQ" name="Drug" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Observer id="2qTJKDMjRUyUUFiGQiHI2g" name="Whole Blood" description="Whole Blood" persistable="1" isFixedValue="0" formula="BQIQTUcNiUS8HwIPoVaLiw" dim="MolarConcentration" quantityType="Drug, Observer" />
-                  </Children>
-                </Container>
-              </Children>
-            </Container>
-            <Container id="uBLlR7CrAkeiLW2yuKLD4g" name="Gallbladder" description="Bile compartment used to collect excretion to the bile" mode="Physical" containerType="Organ">
-              <Tags>
-                <Tag value="Gallbladder" />
-                <Tag value="Liver" />
-              </Tags>
-              <Children>
-                <Parameter id="CcQ10rEozkOSI1Z1aHUY1g" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="64UbBuJae0mSIhmUmTsL2A" dim="Volume" quantityType="0" />
-                <Parameter id="8VByRPnqG0yAjgZOOIBSBg" name="Gallbladder emptying rate" description="Rate of gallbladder emptying" persistable="0" isFixedValue="0" formula="wYZ8533pYEmU6HKGO-98SA" dim="Rate" quantityType="0" />
-                <Parameter id="TvYFW5WNJUKmN7arW_UC5w" name="Time to complete gallbladder refilling" description="Time to complete gallbladder refilling" persistable="0" isFixedValue="0" formula="x5whAEr6sUWDFWkFTqNeVQ" dim="Time" quantityType="0" />
-                <Parameter id="0P1b64Hmckie0Y-dZ4AApw" name="Gallbladder ejection half-time" description="Gallbladder ejection half-time" persistable="0" isFixedValue="0" formula="jA_-KwKKWEez1rARX6HxYA" dim="Time" quantityType="0" />
-                <Parameter id="1CS1Y97u-kC-hFqmSBa_fw" name="Gallbladder ejection fraction" description="Gallbladder ejection fraction" persistable="0" isFixedValue="0" formula="XqVtHKq2U0K7uqkKMvuTVg" dim="Fraction" quantityType="0" />
-                <MoleculeAmount id="bC6OL3OSKECC8fraNnuVyw" name="Drug" icon="Drug" persistable="1" isFixedValue="0" formula="SHM1FGagoUu0Jy0p-6rwFg" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1">
-                  <Children>
-                    <Parameter id="xXggsJKNmU2efmLgqa1B9Q" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                  </Children>
-                </MoleculeAmount>
-              </Children>
-            </Container>
-            <Container id="EqILaEnTM0ylm88Ggqudpg" name="Bone" description="Bone" icon="Bone" mode="Logical" containerType="Organ">
-              <Tags>
-                <Tag value="Bone" />
-                <Tag value="TissueOrgan" />
-              </Tags>
-              <Children>
-                <Parameter id="D0dHwZaBxkSVhJXUwrbe5Q" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" formula="mVEWvGqrgE-KcEv8JHNkQw" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="KAYNz37O2k2jBhCC97r8pw" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" formula="qulfGMl9HUK_L28fGYesuQ" dim="Volume" quantityType="0" />
-                <Parameter id="o0lB4dPls0GTiXKCcUPdow" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" formula="FbGzbaLst0K5o2gc_gSjaQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="vWnJsV4Kmk-vrWVAjY-haA" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" persistable="0" isFixedValue="0" formula="usQNXsnT2U-2Q2tUMH2REw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="m2blpMvT0Eywl5bb0Cgh-Q" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" formula="C_8JmsGDIkaf_jh0oyN8Ag" dim="Density" quantityType="0" />
-                <Parameter id="nElWeYYBQkuZYqOVjrvjdw" name="Peripheral blood flow fraction" description="Blood flow fraction in organ used for calculation of peripheral venous blood concentrations" persistable="0" isFixedValue="0" formula="t7Hu2Yh8w0mhQlW789Babw" dim="Fraction" quantityType="0" />
-                <Parameter id="mrwPMobM2UeSMcRFIuhgKA" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" formula="3GlRek-RJEudqODcTtbdOg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="JO6zQcKrGEaA8ycAGh1dBg" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" formula="uImNZ4jsvEOkkPlPrxu8AA" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="egk4pZlfKUCzH6CpOLiWQA" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" formula="TrjcG_Mkykue_Yb-MnZ8Fw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="iaTP2md2rEWLshytNQg3UQ" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" formula="-I4_phy_xEuhptvfuU_xPQ" dim="Nanolength" quantityType="0" />
-                <Parameter id="0Lv7Wsfec0q5rAkrfLd3_w" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" formula="1zxP7UYUHEema4XupnoPww" dim="Nanolength" quantityType="0" />
-                <Parameter id="pNuVF2CJ00-y9JqPuzWmmg" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" formula="pw7XuWjy8E61auWIlObw0w" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="iLY76Rpw90-rwdWNzuVkcw" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" formula="8W1lciQI5EWPLP7wbBij-A" dim="HydraulicConductivity" quantityType="0" />
-                <Parameter id="uvOoUc6h-kSeVfS3VRecTQ" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="JPp_YHBI1EWQdIkt3ITDGA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="Z3MbzLZB7k-g47JYgicbFg" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="qsJXHGK0f0Gefj5LqVKhVQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="yQQ1OQ3VTE-bpZzSq3vUjQ" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" formula="sPAXBktUCEOYlEow6E1RcA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="vC9y5pC9jEu61AququkHKQ" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="H2yyJmRPVkWNE7uxdD7FEA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="Mq192xCsnEW-x5DmxRmbVw" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="Of4qnfUOpUOiDcXAH-XzIg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="71BDhgLv80Gz5dwOCCxnfQ" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="e3lye7d7pEGHoMKNWHlaRg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="otwKon_S-Ei4j9xH4z1dWA" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="5UwNB5_fB0ynpscEDJkfNg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="Hkcu3uP89EOHihml6m_DrQ" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="IIy9E9lIkkimcJA39LXyMA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="dTZU3FM8YkaNnE563X_8aQ" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="Wd5kaK_ENUWElE9axMtvfg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="oOy1s0Uk9E6kNkStXk5Z1w" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="KjtEyq7YgUmcp-AvsIrW9Q" dim="Dimensionless" quantityType="0" />
-                <Parameter id="GxQfCUg-IkSXgEkwGuDtRA" name="Microsomal protein mass/g tissue" description="Microsomal protein content per gram tissue" persistable="0" isFixedValue="0" formula="8IVF0Rs2aUmACEdQObwKKQ" dim="MassProteinPerTissue" quantityType="0" />
-                <Parameter id="TgQXJShXVk60KpU4W6knjQ" name="Number of cells/g tissue" description="Number of cells per gram tissue" persistable="0" isFixedValue="0" formula="ur4uw14dakGAm1fw3xsGRA" dim="CellQuantityPerTissue" quantityType="0" />
-                <Parameter id="JCItyR7NQkSWMxOPz6KjkQ" name="Protein mass/g tissue" description="Total protein content per gram tissue" persistable="0" isFixedValue="0" formula="EEqGbnp-PU6mGb55Bq45pA" dim="MassProteinPerTissue" quantityType="0" />
-                <Parameter id="lYhtj3lI-UmNIjY_14WWSw" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" formula="YAHBuQW6ok6xKJYf7jD5uQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="qdCCyjgrEEWm2oqDq2C6MA" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="sFBtCoiWG06SjVIO2wHHxA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="en5mVcg-TUaVcegc7tMgAQ" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="Krvya-6hC0SfzFnlRlmBMw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="JTB45ZOcbkWx8_mD4VXLcQ" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="RAD0VbcoVU-nR0gs5d41mw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="0YQkjrS7nU-Lh-egCiqu_w" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="_-_XtyNGOESQxt8sF5iUXw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="6RcQG49nEkCxbvh8VDA2GQ" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="_LUPezUUx0W3fzF7qPmScg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="epd01XMSaEiA1SFPC_exEA" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="MoPE9r9AjUyB8gv4SWa0yQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="ph9jZc2oS0qs2enK60517w" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="K7rtQ-ShAU2QQLGAJ-3yrQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="hF7jocXmgESSYr7B8JMn6w" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="9RQp7xUrlkCTgKLncnR5Mg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="DK7FZruKr0yswqxv2ui20w" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="h_9nYQxnJkipASjzDLcKCg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="lQaWBE4i1Eq49Sb07BgyVg" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="2YTrEOEB8kmjVbgdd5cHow" dim="Dimensionless" quantityType="0" />
-                <DistributedParameter id="zI7Hz5gdDUyA00SBK8PqwA" name="Specific blood flow rate" description="Blood flow rate normalized to the organ volume" persistable="1" isFixedValue="0" formula="THMjGpwZUECidTvnZ7Nh8w" dim="Flow (volume) per organ weight" quantityType="0" mode="Logical">
-                  <Children>
-                    <Parameter id="zAmmXfHogkSi13Sv1OAZYA" name="Percentile" persistable="0" isFixedValue="0" formula="Kc71hB62bUiTI_gtyoBxCw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="AanOkkslKkiRHR5KhKRwPA" name="Mean" persistable="0" isFixedValue="0" formula="mZ5jveEHAUmp66cut_HeIg" dim="Flow (volume) per organ weight" quantityType="0" />
-                    <Parameter id="H-Kl6NMTOUGZ4VICtY7zvw" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" formula="olX-N_XED0ivPGF8BduwyA" dim="Flow (volume) per organ weight" quantityType="0" />
-                  </Children>
-                </DistributedParameter>
-                <DistributedParameter id="qExc73tqSUaQhpa--uqTKg" name="Volume" description="Volume of organ or compartment" persistable="1" isFixedValue="0" formula="75Bs28eFpU-CVpAJoRA2zg" dim="Volume" quantityType="0" mode="Logical">
-                  <Children>
-                    <Parameter id="MBr-YmZl0kSOqdB28wXvSw" name="Percentile" persistable="0" isFixedValue="0" formula="qx_QWmsyU0mvnyi2ESH8hg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="PkHcdo84-UyTIyxmtW4yCQ" name="Mean" persistable="0" isFixedValue="0" formula="NKgNIpKdxkS8qHtefG9w4g" dim="Volume" quantityType="0" />
-                    <Parameter id="ofZRDxl0WUCZKxT5ARDMag" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" formula="1W04BaRc6kikwUL7MjygLw" dim="Volume" quantityType="0" />
-                  </Children>
-                </DistributedParameter>
-                <Container id="pdisLuqFw0KHSEKiS47vmg" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Plasma" />
-                    <Tag value="Bone" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="IZizVOKACk2XKwdkYsJ2lg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="owgI66XQcE2ClB4BHV50ew" dim="Volume" quantityType="0" />
-                    <Parameter id="PsFAK5xyGEihgFEgr6MjQA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="rbp4e7PXpUyuD1ZtA8Ocxw" dim="Volume" quantityType="0" />
-                    <MoleculeAmount id="W1-NePRLxkyUOBkmLtikoA" name="Drug" icon="Drug" persistable="0" isFixedValue="0" formula="sLu6zAA0SUmY20vYazmjHw" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="sY-6qUdti0eCJ7Qa0Zec0w" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Parameter id="FB7UOiwvk0adN0twuU1BgQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="MioCu6D8lEKKPeEuV4Jhrg" dim="Dimensionless" quantityType="0" />
-                        <Observer id="D8z9xcBgnEyOozLw147FMw" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Drug, Observer" />
-                      </Children>
-                    </MoleculeAmount>
-                    <MoleculeAmount id="43n2P-HlX0-FSD-l_XdXrQ" name="Cyp" icon="Enzyme" persistable="0" isFixedValue="0" formula="wb5yCXJZxUeVY_7iSBmoSg" dim="Amount" quantityType="Enzyme" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="OYCpk5HxHkWWM-ZO4rZiWw" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" formula="fx9eZeXqZkye7wY7-zcZaA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="99kfTtKBnkq17p4XvomTMQ" name="Relative expression out." description="Relative Expression that will be used in the simulation" persistable="0" isFixedValue="0" formula="GtBZCb_uvUKgURPKDkyZKA" dim="Fraction" quantityType="0" />
-                        <Parameter id="V1ZfuGVxHEKdiL6r53g3Qw" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" persistable="0" isFixedValue="0" formula="Qv2OyMi-nU-kPqJ48WVuVw" dim="Fraction" quantityType="0" />
-                        <Parameter id="ggMnQd1WOkSNmQKXKXuoyA" name="Relative expression" description="Relative expression" persistable="0" isFixedValue="0" formula="iUzjEbj_NkSh4u8TNBhFgQ" dim="Fraction" quantityType="0" />
-                        <Parameter id="73jJChTUpkiArasb1bhpRA" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Observer id="oO1OmbMAVEC33du3cWnOgg" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Enzyme, Observer" />
-                      </Children>
-                    </MoleculeAmount>
-                    <MoleculeAmount id="JXajNGRKd0-CasoCXSk_mQ" name="Drug-Cyp Metabolite" persistable="0" isFixedValue="0" formula="NbslKT5s7UawMymY13qvyg" dim="Amount" quantityType="Metabolite" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="PPvreSCa2k-cwSAoVi-RjQ" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Observer id="cYzcBB1KPku5uTAYo60dEw" name="Fraction of dose" description="Metabolized fraction of administered dose" persistable="1" isFixedValue="0" formula="aUoTQ3n3a0OShljd8bUj3w" dim="Fraction" quantityType="Metabolite, Observer" />
-                      </Children>
-                    </MoleculeAmount>
-                    <Reaction id="StZ3s0EELEagyt2YvC3Apg" name="Cyp-ME" icon="Metabolism" mode="Logical" containerType="Other" dimension="Dimensionless" formula="NrKgrsKmwkiGET1q7OIPYg">
-                      <Educts>
-                        <ReactionPartner stoichiometricCoefficient="1" partner="W1-NePRLxkyUOBkmLtikoA" />
-                      </Educts>
-                      <Products>
-                        <ReactionPartner stoichiometricCoefficient="1" partner="JXajNGRKd0-CasoCXSk_mQ" />
-                      </Products>
-                      <ModifierNames>
-                        <ModifierNamesChild>Cyp</ModifierNamesChild>
-                      </ModifierNames>
-                    </Reaction>
-                  </Children>
-                </Container>
-                <Container id="9PgVSRUEFky2ekQwkIaHHw" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="BloodCells" />
-                    <Tag value="Bone" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="fgBlkaX6PESR4gfgWnpE4A" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="owgI66XQcE2ClB4BHV50ew" dim="Volume" quantityType="0" />
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-              <Tags>
-                <Tag value="Brain" />
-                <Tag value="TissueOrgan" />
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-                <Parameter id="RNRBKV0fDE2PS_fC7ZJVQg" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" formula="oyJuhobQiE26k0PCriklCA" dim="Volume" quantityType="0" />
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-                <Parameter id="hFYFqueDMUKXHW0zgBbrQQ" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" formula="7pxDSRmQFEmX_5IGu4SNpw" dim="Density" quantityType="0" />
-                <Parameter id="U9ZI_yVKcEeFc_nZrCBcng" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" formula="qWx5dRXpj02sQcXg1xVAqw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="aCRE5TagX0GW2K_kqqVo-w" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" formula="FV63PVptTEiimxYdW9Q93w" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="mv79Dc6n1U-G9uOjOA49Cw" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" formula="xtHV1DkEC0WC8vsmcYSBdQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="yQugq8gdUEi5j0YdDTYAOw" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" formula="oNJgIT8IX0GxOIlO9ltk1w" dim="HydraulicConductivity" quantityType="0" />
-                <Parameter id="1BRyn1kgn0yynyj0S4wHtg" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" formula="o8DE-FLDHEyXwnywe3X2yg" dim="Nanolength" quantityType="0" />
-                <Parameter id="Ej3gz_pmekGlYwjl2uzHng" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" formula="vMf3E8tlEU6vpf6i6Gbg4A" dim="Nanolength" quantityType="0" />
-                <Parameter id="gfbToRNlCECFokhydT17Cg" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" formula="JPaHVx9nEECXqNV2_hegsA" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="qqAAiZoDH068WddyyPpwpA" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="eoFFLn8h_UOCHrs0KggbIQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="kotV_aVZUUGXqv7x4QaWAg" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="4cJ3vHbaqEmvzzyeZfpC5A" dim="Dimensionless" quantityType="0" />
-                <Parameter id="b5l7WDGoxEKT80YcNpgW1A" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" formula="JBiyu3J3V0OR10g-MH6Qjg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="0CYuPMT6R0eHgiDa9sy_sg" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="U3a186dIOk2RpPwh4i12cA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="wXMf9VS-sEe4KjJKWUvBww" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="9cckqA4cgEeUO8SG7jnpfw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="7d0U07tAKUesVn0hjsYLZA" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="dEK3_dEF-U2RQdwgNGjFjw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="IuHOayf3fEK-Snv5AlcLHg" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="D9KxTMRnDkugUKZCBzSFZg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="qM5CfrdNSki3TDZeitIOPA" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="y_5jolYphEuB0Xam7OS0Vw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="xA34asZXEk6vAIBneCIjwA" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="jNqSvb8IRU6RR4S6MfsciQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="xfACaQcp_U2Jx3lbLRyWkg" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="iGlOcCxAVU2DeA1UdQxAqA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="zJhxNaNphkqwKlomHnDAdQ" name="Number of cells/g tissue" description="Number of cells per gram tissue" persistable="0" isFixedValue="0" formula="BOhvlz2Fv0ySD6hUp5bxdg" dim="CellQuantityPerTissue" quantityType="0" />
-                <Parameter id="Qm4u6i3jSkCKUQIR9eWABA" name="Microsomal protein mass/g tissue" description="Microsomal protein content per gram tissue" persistable="0" isFixedValue="0" formula="jd5Gek7__U6MFgOeFz-AiQ" dim="MassProteinPerTissue" quantityType="0" />
-                <Parameter id="k4BGOODCDEC8Qem8NzxOFA" name="Protein mass/g tissue" description="Total protein content per gram tissue" persistable="0" isFixedValue="0" formula="E1gtDr1aAEi_f0A1ClYzrw" dim="MassProteinPerTissue" quantityType="0" />
-                <Parameter id="lJ17EcPM_Uu9kNpgBBvsCg" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" formula="rrEgdr3d-0-8O41eaJnv5g" dim="Dimensionless" quantityType="0" />
-                <Parameter id="RMMkH3qCZkaZkLmzTgPLqQ" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="cQVHGNuWvEqbCTI4lftc-w" dim="Dimensionless" quantityType="0" />
-                <Parameter id="Mn3XTgGA1kCHDj2A9G142g" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="Zh_hw2BKvEGqjTXi-1LKnQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="5lRPuVNdCkWPCmrY0NeNmA" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="g05nThbk4kqf4vL8HDx3Og" dim="Dimensionless" quantityType="0" />
-                <Parameter id="15CCCpLCU0K4lXYqWwWvcA" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="BwsUE-S7Bk2AgYQ2KPExUg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="_rs95BuvoE6laMWL0KE1DA" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="yz5V0WjnMEq4684mXN3mVQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="GByai_NDPUS7-_6TCYft-w" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="CMEqh_FpA0i0CE_LpQyrqw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="NWsRnAGLyUmJS6E3xtgjCQ" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="hg_0sfCVv0aHumeLSzTjmw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="7RjRhO_TXUiDeezdarFPJA" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="0XilLSOSj0WAC10Q3tHG2g" dim="Dimensionless" quantityType="0" />
-                <Parameter id="Cy8sLGrU_U6IbieqXoGA6w" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="_PEYQMYrsUqawN_0bxghnA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="fW_eYLcvKEeQSv5G-mEQYQ" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="gFKznHjPX0WK0EnyKQo6HA" dim="Dimensionless" quantityType="0" />
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-                    <Parameter id="hjRqd6bIF02EPqdKFPnDVw" name="Mean" persistable="0" isFixedValue="0" formula="H37vkAJ7rkC1FA493T3XJQ" dim="Flow (volume) per organ weight" quantityType="0" />
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-                    <Parameter id="GmRi25fOTE-p1iTRBv_TvA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="owgI66XQcE2ClB4BHV50ew" dim="Volume" quantityType="0" />
-                    <Parameter id="95vbRyfeVUSSRuC8hYX6UQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="rbp4e7PXpUyuD1ZtA8Ocxw" dim="Volume" quantityType="0" />
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-                        <Parameter id="84AcTp1RKUyXEP6GGvVGLA" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" persistable="0" isFixedValue="0" formula="mKQH3bCNBk6gqb605yY_1Q" dim="Fraction" quantityType="0" />
-                        <Parameter id="hgz0CcsT0EWywoOIUyg8mQ" name="Relative expression" description="Relative expression" persistable="0" isFixedValue="0" formula="hceH4knuF0SUQsH75UIp6Q" dim="Fraction" quantityType="0" />
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-              <Tags>
-                <Tag value="Fat" />
-                <Tag value="TissueOrgan" />
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-                <Parameter id="M3UVzxMFGkWNBN_KCxUCHQ" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" formula="Jj_R4K3uOEO127sBueRNwg" dim="Volume" quantityType="0" />
-                <Parameter id="4IFk092LNUKpz5DoyjZL7w" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" formula="FbGzbaLst0K5o2gc_gSjaQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="oJaezHFt3kmu10udhFHdgw" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" formula="mVEWvGqrgE-KcEv8JHNkQw" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="LqIy7a4-EEagFkqUf961Yg" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" persistable="0" isFixedValue="0" formula="GE_bESOmFEqpX6Bc85VZGg" dim="Dimensionless" quantityType="0" />
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-                <Parameter id="C8fAtQPauUmLybx80qrp9A" name="Peripheral blood flow fraction" description="Blood flow fraction in organ used for calculation of peripheral venous blood concentrations" persistable="0" isFixedValue="0" formula="fgaYU_ATQ0W_VUsbW5A17A" dim="Fraction" quantityType="0" />
-                <Parameter id="BSlPDiUEfkyoKUSCi5capA" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" formula="KWy0bnTK0kOpUlDOCmAtzg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="V__2JQMxT0GCJZOA1UNfsA" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" formula="6jKNmqw6MECJVUFls9_Mvg" dim="Nanolength" quantityType="0" />
-                <Parameter id="8F5DAW-GAEWfNJPsn8u1Ug" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" formula="7gG0wLzmQU-ZDbBQ_XmsbA" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="JFrPSbtj-ka4vWtDWw4nTQ" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" formula="jjiuGOnMsUKAjnSGh6xezw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="wrLGOLYV8UOQyhwn_xUMDg" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" formula="i9R-bjyfXkeGKnd9eHPOQA" dim="Nanolength" quantityType="0" />
-                <Parameter id="niFlngnQykeNJtDuCCi2Wg" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" formula="Btm0Vtfz3USOKlevHpCwHQ" dim="HydraulicConductivity" quantityType="0" />
-                <Parameter id="s6nmycz00UCRcyWa4hBSuQ" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" formula="DVJZpfEJC0euJKXCJqoPpQ" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="XaZdIEKo-Eettuo3rnnHjA" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="bFdic2NV_UOw68smwg31Zg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="otOJfcZB70iumX5Xz3axsg" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="hyjYKWYzQkKcpfW1MdA0wA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="tbTtQk5cDU6_4vUWz-y_0g" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" formula="uu6PSDtxJUOXhnvlhg7HaQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="SO3IpL1Mi0a1vOMPnU3jxQ" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="M9RFdrLcSU2iKVp3mdu0Xw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="iTQfUDHipUqaPtBH5eaBiQ" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="b_xdaNyWAEag05aaWVitPw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="FiXva3FlJ02Yj33Pm1mboA" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="VT6UUxamkEyrwC_U-HBXPQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="WKFEw1Gb5EahfoNbBDDQIQ" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="Bd0d0GYB1UWbfLpt_Vd2LA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="MMyodd_qpUCnXCFmNEl8rQ" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="rQqvIzuHPkqHOv3-XHd7KA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="_JYrmeyvjkexowKwK8oQEQ" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="qF0BYv0gUk2VAoRloHYERA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="kTmibyKDdk-L5x1icabshg" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="Zva6sv6ddkaEdmOrS5YOMg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="EbD83ta1GUq37F_hm2JVwA" name="Number of cells/g tissue" description="Number of cells per gram tissue" persistable="0" isFixedValue="0" formula="u9m1CjJ8jU2oCqY8aG72lw" dim="CellQuantityPerTissue" quantityType="0" />
-                <Parameter id="vABUAuIseUuXDIwHbEL5EQ" name="Protein mass/g tissue" description="Total protein content per gram tissue" persistable="0" isFixedValue="0" formula="TB7wnwxHN0eVmm7BTYN1CQ" dim="MassProteinPerTissue" quantityType="0" />
-                <Parameter id="c-l2klyajEKm0UEdIPW4YQ" name="Microsomal protein mass/g tissue" description="Microsomal protein content per gram tissue" persistable="0" isFixedValue="0" formula="BnrPzYTifUm-Dj_cwx6srw" dim="MassProteinPerTissue" quantityType="0" />
-                <Parameter id="Vit60vmC5UqeaOMvjTvHzg" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="dk8nDlGcbEeu64Shi4w96g" dim="Dimensionless" quantityType="0" />
-                <Parameter id="QawlXbPC7Eqr9CIST7PJ3g" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="MJfonTPYNEuqGb80p9FXSw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="46MY4obdiEOkQ-hL78gebg" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="xok_VUyIdkui6Tuogqic9w" dim="Dimensionless" quantityType="0" />
-                <Parameter id="XDRoKBoynEm_QYhA1JlqQw" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="b7pvH6vy9kWFQTvCbVesrw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="aBwcIwAL0UmrfJMAw5LoOQ" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="3JQLVtBiLEKwaRSP0csFbQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="EOFf3cf_C0uvjqy9lmztZQ" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="Of97T0aJQkWjsZHClOuHEA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="PCOJdSAOI0KF5QqwA5E1tg" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="cEpo9p6XU0CwD1Hf0hnPYw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="88AhRvW9nkay7yEJ0pR64Q" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="Gk65UZtPMUCYl8l3dAwoBw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="35lR_TVOOk-U-RW95NexIw" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="1A9W694QskuSkXR1WunQcw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="8rET-5sRdE2U3IDEr9lC3Q" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="jsVwS_V8zEOueYBHpMP1LA" dim="Dimensionless" quantityType="0" />
-                <DistributedParameter id="0-O5DaMBq0iG3Hg8PlcMbg" name="Volume fraction lipids scale factor" description="Volume fraction lipids scalefactor" persistable="1" isFixedValue="0" formula="kANLusO8wEu_ab3YlgknfA" dim="Dimensionless" quantityType="0" mode="Logical">
-                  <Children>
-                    <Parameter id="-tYmWy7NkUeLF0WP5qaCvg" name="Percentile" persistable="0" isFixedValue="0" formula="1junKlJr_EqCnWYMghgGuQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="6cUnTiEj60u97kKCeXAzdQ" name="Mean" persistable="0" isFixedValue="0" formula="kvruXTmC80WbTk14oZsIaA" dim="Dimensionless" quantityType="0" />
-                  </Children>
-                </DistributedParameter>
-                <DistributedParameter id="VL4WbudSdE2YpafaQPOmaA" name="Volume fraction water scale factor" description="Volume fraction proteins scalefactor" persistable="1" isFixedValue="0" formula="f0vOJ563B0ao1y4chpaI7g" dim="Dimensionless" quantityType="0" mode="Logical">
-                  <Children>
-                    <Parameter id="JD2GwCLepkipTDhqmcf0Ew" name="Percentile" persistable="0" isFixedValue="0" formula="Ammm7dZkH0CjxQ59nZGifg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="mLv0O6nsWUGrmMW16UP8LQ" name="Mean" persistable="0" isFixedValue="0" formula="JMWbSSitXU6wtvRxHzOwqQ" dim="Dimensionless" quantityType="0" />
-                  </Children>
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-                <DistributedParameter id="uutOvgRoO0S95hwJqj4A-A" name="Volume" description="Volume of organ or compartment" persistable="1" isFixedValue="0" formula="Ej4lGio2VUC658ClPs-nXQ" dim="Volume" quantityType="0" mode="Logical">
-                  <Children>
-                    <Parameter id="trvm4mcVEkCPuyZJtDhrZw" name="Percentile" persistable="0" isFixedValue="0" formula="0Mdg5mOtA06wIDR--_SWig" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="pO-oFQiH40qt04JU34s7-w" name="Mean" persistable="0" isFixedValue="0" formula="KmnqGdcVyk2pkJaS5HUBeA" dim="Volume" quantityType="0" />
-                    <Parameter id="zjN4pposbki8TXc3MiWfBA" name="GeometricDeviation" description="Geometric standard deviation of LogNormal distribution" persistable="0" isFixedValue="0" formula="3zE6QHQ4jkalFWA9nJh_FQ" dim="Dimensionless" quantityType="0" />
-                  </Children>
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-                <DistributedParameter id="oRoTE1fonEqNbFe6KPxZPA" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="1" isFixedValue="0" formula="Jo9aV_gFC0-bKqA6eIRjpw" dim="Dimensionless" quantityType="0" mode="Logical">
-                  <Children>
-                    <Parameter id="DllS9yyxJUGqx8G4wiEiRA" name="Percentile" persistable="0" isFixedValue="0" formula="jmkWZqIHUkSAtlvmIIYnRQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="dS6o36zbeEiB6HSTsojk6A" name="Mean" persistable="0" isFixedValue="0" formula="VeB_dClFu0q_kg1Gq3RKlA" dim="Dimensionless" quantityType="0" />
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-                <DistributedParameter id="4UHX2T4m9kWa1s5WYdR_wA" name="Specific blood flow rate" description="Blood flow rate normalized to the organ volume" persistable="1" isFixedValue="0" formula="rYKp5FA8yEilvSc4p9w6hw" dim="Flow (volume) per organ weight" quantityType="0" mode="Logical">
-                  <Children>
-                    <Parameter id="f1ZC9yiB-keGu75QQNHCuQ" name="Percentile" persistable="0" isFixedValue="0" formula="kHzn71Zp2k6kJ_uFFalwNQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="_x5eFCXPoECuTlhfXhoDMA" name="Mean" persistable="0" isFixedValue="0" formula="knqYDODKSEO_bhgbTTsIwA" dim="Flow (volume) per organ weight" quantityType="0" />
-                    <Parameter id="quoALhydQkiTtw-ddRB_4A" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" formula="u3-xNSDwBkCbC4Oy1wR9gA" dim="Flow (volume) per organ weight" quantityType="0" />
-                  </Children>
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-                <Container id="0jH8wQWByEGQirnpU3MU9w" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Plasma" />
-                    <Tag value="Fat" />
-                  </Tags>
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-                    <Parameter id="Hj9cqh9zSUK3X21j92aMSw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="owgI66XQcE2ClB4BHV50ew" dim="Volume" quantityType="0" />
-                    <Parameter id="CkpSjPkkik-VpLEE0RVXaQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="rbp4e7PXpUyuD1ZtA8Ocxw" dim="Volume" quantityType="0" />
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-                        <Parameter id="qrdvDvKFvUy2AvhvJxD3vw" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Parameter id="L0lOigHWaUy6KQBTnIv4KA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="Ke9ZXVztbE2mxe8Zs80EqQ" dim="Dimensionless" quantityType="0" />
-                        <Observer id="ZaunfrU7tUqM0KvBUgQ9mg" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Drug, Observer" />
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-                    <MoleculeAmount id="FfaBOSkirU-wNG9BHQWMuA" name="Cyp" icon="Enzyme" persistable="0" isFixedValue="0" formula="wb5yCXJZxUeVY_7iSBmoSg" dim="Amount" quantityType="Enzyme" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="Ng3VRydaA0yHeVygnSZPvg" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" formula="EtcdKJ_2M0m4BQ1PC3ar8g" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="SdRW2DIyR0O2JasMDRdmUg" name="Relative expression out." description="Relative Expression that will be used in the simulation" persistable="0" isFixedValue="0" formula="GtBZCb_uvUKgURPKDkyZKA" dim="Fraction" quantityType="0" />
-                        <Parameter id="9CB49weePkuTIlkIY-7YnA" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" persistable="0" isFixedValue="0" formula="Qv2OyMi-nU-kPqJ48WVuVw" dim="Fraction" quantityType="0" />
-                        <Parameter id="wPPdYaO-Y06O9IzrPnwTFQ" name="Relative expression" description="Relative expression" persistable="0" isFixedValue="0" formula="iUzjEbj_NkSh4u8TNBhFgQ" dim="Fraction" quantityType="0" />
-                        <Parameter id="FAmKYI5Xxk-CxHU230eJCw" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
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-                      <Children>
-                        <Parameter id="i7eCRSjwuEKYqU9D-D7WGw" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Observer id="DYMjufgBJE2cKK6bOWdnlQ" name="Fraction of dose" description="Metabolized fraction of administered dose" persistable="1" isFixedValue="0" formula="aUoTQ3n3a0OShljd8bUj3w" dim="Fraction" quantityType="Metabolite, Observer" />
-                      </Children>
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-                      <Educts>
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-                      </Products>
-                      <ModifierNames>
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-                <Container id="UCI13t7Y1UeZyAqMB-vPQA" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="BloodCells" />
-                    <Tag value="Fat" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="Tu97Eyp82EK7ypGYSoHXdg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="owgI66XQcE2ClB4BHV50ew" dim="Volume" quantityType="0" />
-                    <Parameter id="pqJGep8aJ0S5YuvHyL_Mrg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="tFZiRJ-Sv0qf0gsV7ycmYw" dim="Volume" quantityType="0" />
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-                      <Children>
-                        <Parameter id="OnUCgdQu4EKrTU_FvnQdYg" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" formula="rxrGrIdwsEOZGcO6iXR9Hw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="4UJjhqj6_UCgABHjLqhM6Q" name="Relative expression out." description="Relative Expression that will be used in the simulation" persistable="0" isFixedValue="0" formula="GtBZCb_uvUKgURPKDkyZKA" dim="Fraction" quantityType="0" />
-                        <Parameter id="sQ5VVGL06EGbFTGEdFEAYg" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" persistable="0" isFixedValue="0" formula="FTxLv_b4CkKigLwWdcA4xg" dim="Fraction" quantityType="0" />
-                        <Parameter id="Tyf4D7TgTUGKc8MsbgMdnw" name="Relative expression" description="Relative expression" persistable="0" isFixedValue="0" formula="_J3C13ewoUatoCS2w-zxeg" dim="Fraction" quantityType="0" />
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-                        <Parameter id="SO5r1yzJnUSzORpx6eHB6g" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
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-                      <Educts>
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-                <Container id="i5oPN6d4TUivselGMRZdYg" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Interstitial" />
-                    <Tag value="Fat" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="voPbiJF_7kWrVxYGkdSOsw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="owgI66XQcE2ClB4BHV50ew" dim="Volume" quantityType="0" />
-                    <Parameter id="jrzBCeYfaUGI2VNP-z4wQw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="4VSppd3W3E6-12kllCJ0Mg" dim="Volume" quantityType="0" />
-                    <Parameter id="XSSUmOmnyUW-SIeDaaWXzg" name="pH" description="pH" persistable="0" isFixedValue="0" formula="tKjHIxsi60KoHEPhXQBZrw" dim="Dimensionless" quantityType="0" />
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-                  <Tags>
-                    <Tag value="Intracellular" />
-                    <Tag value="Fat" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="lc1xEl_6f0GZjnBCflglfw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="M9arQg_qfEGMA7JdlSXkFA" dim="Volume" quantityType="0" />
-                    <Parameter id="qDPdWTHhKU25WQf_d5e8XQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="3l84whkuX0S7xUUHglUQpg" dim="Volume" quantityType="0" />
-                    <Parameter id="KVzkl0iuokut8eusKd__mw" name="pH" description="pH" persistable="0" isFixedValue="0" formula="KM7IDyttpU6ZFTrDw-Ok_A" dim="Dimensionless" quantityType="0" />
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-                        <Parameter id="aiJ7Lvj5rU2Ugp9xGKQS0g" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Parameter id="_SfrLSzbU0OYfIw5buF7DQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="GVz1I46WakurMubIsU5byg" dim="Dimensionless" quantityType="0" />
-                        <Observer id="64f5MG3mFk-DmZw1KblIvQ" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Drug, Observer" />
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-                    <MoleculeAmount id="NShdAIrPbUSrK-3054JxeQ" name="Cyp" icon="Enzyme" persistable="0" isFixedValue="0" formula="wb5yCXJZxUeVY_7iSBmoSg" dim="Amount" quantityType="Enzyme" mode="Logical" scaleFactor="1">
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-                        <Parameter id="lmfJ787bc0WtNnciHJQWhA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" formula="e3HXmKt8wkKSmyMCRt7D2g" dim="Dimensionless" quantityType="0" />
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-                        <Parameter id="szoMiGNF2k-wJB4YiOPKow" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" persistable="0" isFixedValue="0" formula="_T_2lAWBDUSSzqsXLGcpgg" dim="Fraction" quantityType="0" />
-                        <Parameter id="MvtdpmF610qJN5Um036LKA" name="Relative expression" description="Relative expression" persistable="0" isFixedValue="0" formula="YbGzykqDoE-yRvRy3g4CFg" dim="Fraction" quantityType="0" />
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-                        <Observer id="jADy_bfwrEiaecZFnfBSkQ" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Enzyme, Observer" />
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-                    <MoleculeAmount id="iRx9lbsjgEq_srPQx8q2QQ" name="Drug-Cyp Metabolite" persistable="0" isFixedValue="0" formula="iG4l3WzUaki_r63nt29Q7g" dim="Amount" quantityType="Metabolite" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="tx8A9YG2tEyhCTXF5AAFYw" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Observer id="SaBKqaZuDEm72HXSd3vylA" name="Fraction of dose" description="Metabolized fraction of administered dose" persistable="1" isFixedValue="0" formula="aUoTQ3n3a0OShljd8bUj3w" dim="Fraction" quantityType="Metabolite, Observer" />
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-                      <Educts>
-                        <ReactionPartner stoichiometricCoefficient="1" partner="whncayrIJ0OLCMz2NFh4Ug" />
-                      </Educts>
-                      <Products>
-                        <ReactionPartner stoichiometricCoefficient="1" partner="iRx9lbsjgEq_srPQx8q2QQ" />
-                      </Products>
-                      <ModifierNames>
-                        <ModifierNamesChild>Cyp</ModifierNamesChild>
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-                <Container id="L8Drz1tW1UuSGVbkzcNBMQ" name="Drug" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Observer id="5gpJpmndMEehAF9T4SvDAA" name="Interstitial Unbound" description="Interstitial Unbound" persistable="1" isFixedValue="0" formula="sb2EI4hIhEWxy5ZYMY2QFw" dim="MolarConcentration" quantityType="Drug, Observer" />
-                    <Observer id="nWQ7CRZ_GEmOUyF7qeGKmg" name="Intracellular Unbound" description="Intracellular Unbound" persistable="1" isFixedValue="0" formula="F5kFVlFTnEmJToE6fKssfA" dim="MolarConcentration" quantityType="Drug, Observer" />
-                    <Observer id="Bm2eo2nJXkGPhYVRik_7Pw" name="Tissue" description="Tissue" persistable="1" isFixedValue="0" formula="wztK_G9P_0mMbsEE9LSVMw" dim="MolarConcentration" quantityType="Drug, Observer" />
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-            <Container id="yPB_AXHrMUuZtHaH3uXejg" name="Gonads" description="Gonads" icon="Gonads" mode="Logical" containerType="Organ">
-              <Tags>
-                <Tag value="Gonads" />
-                <Tag value="TissueOrgan" />
-              </Tags>
-              <Children>
-                <Parameter id="T06-joC-60uZ6KoRNdJxQA" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" formula="mENrEOZzv0iIre1zWGJxlg" dim="Volume" quantityType="0" />
-                <Parameter id="rq9fNifA-E-jI-PRRHK4yA" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" formula="FbGzbaLst0K5o2gc_gSjaQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="xT9mEmPMe0mI9B6cZAozFg" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" formula="mVEWvGqrgE-KcEv8JHNkQw" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="4Ucqd-IMqUe5nryZtsMqfg" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" persistable="0" isFixedValue="0" formula="ajYQlCBkCEa93k8rvm8XUA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="Ed5M181pbkGYXrQN6bTFkQ" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" formula="9Sr2tiJBuUmGqfhDE_C22A" dim="Density" quantityType="0" />
-                <Parameter id="5S1b8_qKB0ONK5ftjkIrHA" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" formula="JE6R6oSzFEKywNqDLEVK5g" dim="Dimensionless" quantityType="0" />
-                <Parameter id="VeOvMCwLr06h8uh_WpSfxg" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" formula="76xjif13zU2E0Bq7YrGQ-g" dim="HydraulicConductivity" quantityType="0" />
-                <Parameter id="n87T_gAH3E6R8626trn5Ng" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" formula="RBiKkdjsakuXtGI5iiRRiQ" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="40I5dA2z8E21ruMq3HfGaw" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" formula="is-Aarcg0UKrh0t7d1tfTw" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="Q8xUhrEJdk6msWb1PgNXYQ" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" formula="Z83_ww-1Okm5ccRr9t1LEQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="IzLqU8fh00KjWoipWkE-Iw" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" formula="HnNkIrSaUk60rgtQ0q0kLA" dim="Nanolength" quantityType="0" />
-                <Parameter id="hRE4-9CR5kSZKh--IytXxQ" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" formula="iZQ5LXL6d0iB6IJg0-ykTw" dim="Nanolength" quantityType="0" />
-                <Parameter id="H1HZO4FORkCrdxc5jjMIAA" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="sAS3BD4r3U-qCROhnqJIgQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="fXCDdgulQU6m0H1RCoXWSg" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="ohM45G3IM06H8JuCA9B5pw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="bwuXtJdSzEyerPAQ2o4Ixg" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" formula="7VZIlLRjgECoEHi0EUdwNg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="YtAgffNmnEWm96ZrUKct_Q" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="Jiv6YojyJkm1pj6LfPm9bA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="gBPltlwBAkOqrAfkLkdmKA" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="vlHvRYVL9kGrUCx06BB15w" dim="Dimensionless" quantityType="0" />
-                <Parameter id="s-gr8xzHpkC6eBRiZ3Ifhw" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="VNgSYVXcdEKZP99mBNeq7A" dim="Dimensionless" quantityType="0" />
-                <Parameter id="1A2jAhl3w0G-GmgadSTNWg" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="-wkjDmvORUKKcOxU30F6vA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="gnO43Ebw1E2KHgha_-y3MQ" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="QaokPM-e8EuGE8lSdUT_Yw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="sqRnbE86F0aHqSP7JMu6Bw" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="MstU1krtkkifv-yHzvxSCg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="9Bd3HPBOW06Qsomxz_xx4Q" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="XJCWItnxhUaGEWrM7ZGkZA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="E_feP2fuXESTakbH7NHngg" name="Number of cells/g tissue" description="Number of cells per gram tissue" persistable="0" isFixedValue="0" formula="j0qoSrIsmkK1HwcyUwq0PQ" dim="CellQuantityPerTissue" quantityType="0" />
-                <Parameter id="sZ1JpQDxlkqQsz6dkA6CnQ" name="Protein mass/g tissue" description="Total protein content per gram tissue" persistable="0" isFixedValue="0" formula="0qZSr2nyAUGw7APeBYC3jQ" dim="MassProteinPerTissue" quantityType="0" />
-                <Parameter id="U-uoFFr1n0KtM1ZEGJ1UKg" name="Microsomal protein mass/g tissue" description="Microsomal protein content per gram tissue" persistable="0" isFixedValue="0" formula="oWCwJEZzKkeCqlwJ0QItKA" dim="MassProteinPerTissue" quantityType="0" />
-                <Parameter id="5CaxiItBc0yG2MYj0xnsKg" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" formula="YGNnybEoZku1zEk2tbJ1aA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="nlPXaIfJhE6H6AueTgYm8Q" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="y-YbrbjSDE-KzAgPG1BqRw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="tVC_qpH3R0mgB69fjvDwUA" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="g0zXqHp5cE2NNoEqpLg5xw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="HHK287rtCk6Vhc4HaJDNmQ" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="ACLh92ThpEGANquCPlyjPQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="fLrVkc4_u0KMdrjQwDr34g" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="QLSf_8_3iEajZtRrBXXS9Q" dim="Dimensionless" quantityType="0" />
-                <Parameter id="7ex46gfYn0WRaOa9it0WWQ" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="yxZ8uBc-wEeYMiJwzYQXwA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="oDYc8_urPU2QdsBZvlxPOg" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="1O2_regIfkmirE7ByNL_4w" dim="Dimensionless" quantityType="0" />
-                <Parameter id="6wQ6bOrvMEKZo6ebDgheAA" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="eK3Pyt8J2UaD0aBCfd03-Q" dim="Dimensionless" quantityType="0" />
-                <Parameter id="zS7x-wTALEWmmkh0B57gEQ" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="0BV1cD6lHk6pgUqJDRfkUw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="CbAujklj4Eql0XKtARZf6Q" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="lBK6JMji3kSGqJFWDejH-Q" dim="Dimensionless" quantityType="0" />
-                <Parameter id="dAQreCNyRkqYvuVlSKzGzg" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="FQFx0Z0zjE6QXg3OCnAGWA" dim="Dimensionless" quantityType="0" />
-                <DistributedParameter id="Su_ZXUztjU2fG2bw90nHJw" name="Volume" description="Volume of organ or compartment" persistable="1" isFixedValue="0" formula="RASBPnA5rEKdNR3K104lLA" dim="Volume" quantityType="0" mode="Logical">
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-                    <Parameter id="7gnlTkcr6E-MvZmL_LhiIA" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" formula="ai1fwOsdm06fv2IieUqTpA" dim="Volume" quantityType="0" />
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-                    <Parameter id="BpMPDTIBgkiBrjJ_AQ-S2g" name="Percentile" persistable="0" isFixedValue="0" formula="lHdj0P1GHUmbZo4ia7esPg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="WJt9Qsf6YEOhqwij8pzeuQ" name="Mean" persistable="0" isFixedValue="0" formula="tLqe8DwClEKgen1MVaxbXA" dim="Flow (volume) per organ weight" quantityType="0" />
-                    <Parameter id="s9srEdxNpkOcWukeIZA2Ug" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" formula="9AzO785du0Sk3WlDJDwgyQ" dim="Flow (volume) per organ weight" quantityType="0" />
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-                    <Tag value="Gonads" />
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-                    <Parameter id="liJDt8e-SkyFfgNIpFkJQw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="owgI66XQcE2ClB4BHV50ew" dim="Volume" quantityType="0" />
-                    <Parameter id="yvITmAN2M0OHsASjFbSJyg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="rbp4e7PXpUyuD1ZtA8Ocxw" dim="Volume" quantityType="0" />
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-                        <Parameter id="vkIRcxhb1kyupBe2S5hfmg" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Parameter id="ffMizWgSik2pfTnS6xvFvA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="kV9xdstBy0C5MTVswgi21w" dim="Dimensionless" quantityType="0" />
-                        <Observer id="C2yWIN7PtkGcX_iT-4eZPQ" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Drug, Observer" />
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-                    <MoleculeAmount id="aFRU3qx-Pk6FSH7lDbamHQ" name="Cyp" icon="Enzyme" persistable="0" isFixedValue="0" formula="wb5yCXJZxUeVY_7iSBmoSg" dim="Amount" quantityType="Enzyme" mode="Logical" scaleFactor="1">
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-                        <Parameter id="vS5337jI9E6tDs8s3wS_Rw" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" formula="6dQqq1E2nU-P0j5B0U8vrA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="7LkaM0Z8TUe6Rh8kFVce7w" name="Relative expression out." description="Relative Expression that will be used in the simulation" persistable="0" isFixedValue="0" formula="GtBZCb_uvUKgURPKDkyZKA" dim="Fraction" quantityType="0" />
-                        <Parameter id="Cknj92tzx0mLISDrzK_Dlg" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" persistable="0" isFixedValue="0" formula="Qv2OyMi-nU-kPqJ48WVuVw" dim="Fraction" quantityType="0" />
-                        <Parameter id="MWaetKDQwkmdJ6cPwvORsg" name="Relative expression" description="Relative expression" persistable="0" isFixedValue="0" formula="iUzjEbj_NkSh4u8TNBhFgQ" dim="Fraction" quantityType="0" />
-                        <Parameter id="mqfz4dCe-USk8UDkg5CKLA" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Observer id="BTq83g26hkuVpUUf1JIjqA" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Enzyme, Observer" />
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-                      <Children>
-                        <Parameter id="W-B08bEvf0GzKtd9L9eONw" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
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-                    <Observer id="deuoHYqyKE6FkUXmF-xRIw" name="Tissue" description="Tissue" persistable="1" isFixedValue="0" formula="wztK_G9P_0mMbsEE9LSVMw" dim="MolarConcentration" quantityType="Drug, Observer" />
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-            <Container id="_O3_cwCnBkOMB85p1VdUZw" name="Heart" description="Heart" icon="Heart" mode="Logical" containerType="Organ">
-              <Tags>
-                <Tag value="Heart" />
-                <Tag value="TissueOrgan" />
-              </Tags>
-              <Children>
-                <Parameter id="Urt-4_NAJ0qe-JRdAHFChw" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" formula="-5t3MBZnk0yYLKcNwv0jpw" dim="Volume" quantityType="0" />
-                <Parameter id="nBrTL2I7b0WaY5bBuoB7IA" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" formula="FbGzbaLst0K5o2gc_gSjaQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="lzqBf_Y4LU-x4YgGJdCvUw" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" formula="mVEWvGqrgE-KcEv8JHNkQw" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="xc-fceUqbka86GlA0E-rrA" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" persistable="0" isFixedValue="0" formula="DMAIxtx3RUW057Vghz3kpA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="Su01x7YJ6kmCKe_eBL3f1g" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" formula="girW7mCFNUeCBdJHIACJ6A" dim="Density" quantityType="0" />
-                <Parameter id="-peHqk_tb0ap04FPqnbGIg" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" formula="And2N636h065DBrl-QTVVQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="-DJfuclPCEm8Zg81002YZA" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" formula="jaGVMtVpgEqTVYonlF0hog" dim="Nanolength" quantityType="0" />
-                <Parameter id="vLnqhm_dX0KuU0jTelMqyQ" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" formula="1tN4plpIL0686t19S93usw" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="MkTc_lThsk2aOvzRhJNf6Q" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" formula="xxg3igc-yU265r-3OYL3Mw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="QiLl8gegA0CUkoFD0jjb8A" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" formula="NIUpnVVrJ0Gzx4U8axJ62g" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="4-BdGkDD5UaAgODiwav9Fw" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" formula="msEziGL3VU66dv2K6T7H9w" dim="HydraulicConductivity" quantityType="0" />
-                <Parameter id="6tEi-ZYqEUGgvKBL7w1Hyg" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" formula="0qWUYUeCoUW6PpGISHgd6g" dim="Nanolength" quantityType="0" />
-                <Parameter id="4f1u3kc6YU-Wc9PBpu6jGQ" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="K4iMJ5pPckOAmP6_K3Ft6A" dim="Dimensionless" quantityType="0" />
-                <Parameter id="SgyOSAFYkkKXsx3HLhGJDg" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="EfTE1wNYyU2KHmkBcx0bJQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="MIapfjiMF0WN_rG9XzK8QQ" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" formula="K7E0xgsEPUKrAja8kbs-ng" dim="Dimensionless" quantityType="0" />
-                <Parameter id="FeGejWZ2fEWMI8HEGydx-w" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="z5vQzBiOdE2FxQrcXhCQQQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="S4roh9wBo0-D9WLOaMt-WA" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="iEzWGtRa_0--xEZvjy-tYQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="DykHbWBBx0KggCObsji5ww" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="5NW4YhA1lEawOLcLh2hUNA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="7K5VV3F0DEynCfQxo_e7Kg" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="epCO_gnFUE-1k5OXgbr11g" dim="Dimensionless" quantityType="0" />
-                <Parameter id="DXuTdjQzVU-z-lP6TYM-dQ" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="1ssIo8_iw0G5YNrcvKUkBg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="GSOKz0FmB0GJGl-jCEAi2g" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="QzFrPwf4CUeOTgFYevHEsA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="pkl69Amq8EiBZnh-Z62CTg" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="GA_TzuqrqkG2Ir7wHHqLHA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="P867E2lZ406lXie5ZxvsIQ" name="Microsomal protein mass/g tissue" description="Microsomal protein content per gram tissue" persistable="0" isFixedValue="0" formula="52y76aMOmkKRg9gTJ19E8A" dim="MassProteinPerTissue" quantityType="0" />
-                <Parameter id="PcbiN5QI1EqPgAFwTHEoEg" name="Protein mass/g tissue" description="Total protein content per gram tissue" persistable="0" isFixedValue="0" formula="wo3nGzebGkKyI-XXqmyqdQ" dim="MassProteinPerTissue" quantityType="0" />
-                <Parameter id="NQHCQPUxx0Smx5_Cf5GtQg" name="Number of cells/g tissue" description="Number of cells per gram tissue" persistable="0" isFixedValue="0" formula="m7X5p2V210K1yM1trH47hA" dim="CellQuantityPerTissue" quantityType="0" />
-                <Parameter id="KYkXXx_5A0Kwnyxa_y5X0Q" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" formula="TDWGEclOIU6vRrDlF78hkg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="K6INfBuo-0KdqsNTd4Q1yg" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="wBVjYw__nk2hmQdqIIjp6g" dim="Dimensionless" quantityType="0" />
-                <Parameter id="CcbJstCU6U2o5TfBPktQVQ" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="Xq7s8WXkIEensoW9fvrHjA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="LnSQh3_ohE-pkwETMk1ftw" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="iLwgVJ6-8ES028yADM1lpw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="3Kvcf_7YWESqq2s0HjwzDw" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="HJSk_7iCmUOKTe3KGniJ5g" dim="Dimensionless" quantityType="0" />
-                <Parameter id="MoZ0lR9hiUiGHf0lqnzYuw" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="t_nxH6oEjUOocipTImjspg" dim="Dimensionless" quantityType="0" />
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-                <Parameter id="R9fH5htri0q4WH2yNzqvhg" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="-hYxPxSRiUmDq8TKfDOyhQ" dim="Dimensionless" quantityType="0" />
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-                <Parameter id="QExDPwSxuUmVPF2Nx3DB9w" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="2UD1QtzzZUuOIINCyrCtFQ" dim="Dimensionless" quantityType="0" />
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-                <Parameter id="QXbwqpt68EagAqaVM-MnHw" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" formula="mVEWvGqrgE-KcEv8JHNkQw" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="vL560U7BrUeOf2wL8d4GLw" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" persistable="0" isFixedValue="0" formula="_1-YthrCUU6I9fGEa8oleg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="oa_VR1yJk0uKROm6IzzGVw" name="Volume (standard kidney)" description="Volume (standard kidney)" persistable="0" isFixedValue="0" formula="nwDcw9IPiEGXijPumweL1w" dim="Volume" quantityType="0" />
-                <Parameter id="z-ZwSdWcT0SEcMWgX1uDFQ" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" formula="Am_LXwAYMEyXfGthQQOFuw" dim="Density" quantityType="0" />
-                <Parameter id="ZF_24tSeW0eLKEGCbvQGVg" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" formula="VipIVpzsmkuATpOOvOmU_A" dim="Dimensionless" quantityType="0" />
-                <Parameter id="_3BWIUk_B0yR_poeSNnVkg" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" formula="RnJzXsSkb023HeQT4PHsdA" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="0iEr9PEBjUK-gYLUbE96bQ" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" formula="qIX--gBZdkS2zRpuYZZwUQ" dim="HydraulicConductivity" quantityType="0" />
-                <Parameter id="HhNM8FREIEu-taoqNZOM6w" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" formula="reY4jesZ1U-ttStfaidegw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="df2xJAkroU6biFjFaAjy2Q" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" formula="34emFVvwC0icK_G0q8ehhQ" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="sTXoR6AWSUSjeu4I1qOE3Q" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" formula="_kjvlueJqUuJ7SSm8Ki2oA" dim="Nanolength" quantityType="0" />
-                <Parameter id="Yy-7Hvz9q0abZo81QHGtrg" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" formula="H4b2us1rF0aRsp343mvkGA" dim="Nanolength" quantityType="0" />
-                <Parameter id="3fPwDjmPu0iEz780LIcJmw" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="w1irwf2GTky0l8fVGi4Umw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="rq9dzma-1kiSBdffKn0RZQ" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="eQ3ZJpz5AUaJVSixuco1Bg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="dHMDEBFISEScflAgbSF5yQ" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" formula="xzxCWX2LEk-PnN6ckGKRhQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="3Yj-_vxjo0ebFabN2wzTmg" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="3r2MCexL1EGV_s2lnfIF7w" dim="Dimensionless" quantityType="0" />
-                <Parameter id="fm6teQ1Owku6CE51ExmZEw" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="vXAwJLmC40eDh86DnHTyfQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="QqMoYxZJ4k2vrOMtAbKfdw" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="L8jYJ2xVI0yx8g6XMyWudw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="8Pkk5orCo0Kn8YPbZfq_SQ" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="t2wKOJHIrU-onhIjk606TQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="043OgnvNI0KHVyKXmi9cTQ" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="Q56i3ugyhUqHGhe-H6vuSw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="nG2hULd0D0eq6ozyp9uiIg" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="Y-qs3Tm17E6L4_4w8gROAQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="LxpBUMj6l0m5iq_-pzKfbw" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="HOrhKiG-PUG44-eJ0HtFBA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="WD0rnkVJ1Em65sYQ_WDqMg" name="Number of cells/g tissue" description="Number of cells per gram tissue" persistable="0" isFixedValue="0" formula="7zgqVdDjJUeFGXqYOBzuyg" dim="CellQuantityPerTissue" quantityType="0" />
-                <Parameter id="myb26iNBREWw9JSvrsg3JA" name="Protein mass/g tissue" description="Total protein content per gram tissue" persistable="0" isFixedValue="0" formula="KhUGDtD4vUuskL49EjVmcA" dim="MassProteinPerTissue" quantityType="0" />
-                <Parameter id="NIEwDCE6xUao-hz7SlJwIQ" name="Microsomal protein mass/g tissue" description="Microsomal protein content per gram tissue" persistable="0" isFixedValue="0" formula="KMHkNcJQW06KouvR6em87A" dim="MassProteinPerTissue" quantityType="0" />
-                <Parameter id="qevq6BSyc0eCzOiP_GgV5g" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" formula="YwfaMyfw8kig7C-uhNGmqw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="2e6pQs12yUGsR7ZlXP9ysg" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="2caojWHVUEKHwH8m7hoiJw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="fBvx1UT8Rku5nrIZnYZUUA" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="ZumxYVLAqkyypom9YkhGFA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="39XMXEgcJEWLqEpYrUctKw" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="weaETI0zi0yrla4VLlmOUw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="Iv8ucKDGhEq27jImX4RCAw" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="9wIJcc39hkC7UVqs8XQ2gQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="6houfyq0Aki9xEI4wSIuYQ" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="9cClF0aUvkOBbQo71dzTlg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="Wl-OWgfogUqnnIpf4IJVHw" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="mdjwHH8zWEG1oC1T7ltwYA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="_4kakXo5ukegnn9DpW1cxQ" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="EdJofAj61U6AqSUYiz3_PA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="b5krle17bEa022M2AQHElw" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="dVPodClI7U-yEhQRcGZgnA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="igR8kJlQ_EKBtZFBCh-_uQ" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="N3Yt7KEoeU6w5o_UwI2Efg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="T6NMfC1iU0yxN4THuSYJLA" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="LRH4MESdT0-bDd4R7nT5wA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="r0-bC2efW06c33jynyQIgQ" name="fGFRpremat" description="Fractional offset in the GFR that corrects for a tendency to slightly underestimate the observed median GFR values in preterm infants below approximately 32 weeks of gestation" persistable="0" isFixedValue="0" formula="sgIn55bLv0C6qjYz4TDMfA" dim="Dimensionless" quantityType="0" />
-                <DistributedParameter id="kZ1ZSFRM5EqHnMUNKuQPJw" name="Volume" description="Volume of organ or compartment" persistable="1" isFixedValue="0" formula="irdiulR1TUmQItEuPb85Gg" dim="Volume" quantityType="0" mode="Logical">
-                  <Children>
-                    <Parameter id="HGaJB4Zg2kSNRgV0qeVA5w" name="Percentile" persistable="0" isFixedValue="0" formula="eL7UcZHnj0O0GhH403EO9g" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="pKU40MIbQ0-ncpQrH3KSog" name="Mean" persistable="0" isFixedValue="0" formula="B0p_dKHVZk6pxza806BXaw" dim="Volume" quantityType="0" />
-                    <Parameter id="Q7KCxiutuEaxE1EV4sH9DA" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" formula="pzcnx_31wkOzQH-qAHT6KQ" dim="Volume" quantityType="0" />
-                  </Children>
-                </DistributedParameter>
-                <DistributedParameter id="0TmlIacyPU-MRjYP0v3FaA" name="TM50 for GFR" description="TM50 for GFR calculation" persistable="1" isFixedValue="0" formula="C6dEMDekvkKXhqhRqNO4ug" dim="AgeInWeeks" quantityType="0" mode="Logical">
-                  <Children>
-                    <Parameter id="Ffq23msrbkq1JpofV0AdyA" name="Percentile" persistable="0" isFixedValue="0" formula="uinhZUWYmE6gS8O7NuaSOg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="SI5BFg2HXEGcA4AwKab1nQ" name="Mean" persistable="0" isFixedValue="0" formula="EwwywjjZKEmh9njYntzFGA" dim="AgeInWeeks" quantityType="0" />
-                    <Parameter id="6Kva85iTDES524QN73NuSw" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" formula="HpPoiqS3xECQeV4tPG4ZRw" dim="AgeInWeeks" quantityType="0" />
-                  </Children>
-                </DistributedParameter>
-                <DistributedParameter id="08xVVNsGM0yxpfAPw52Beg" name="Hill coefficient for GFR" description="Hill coefficient for GFR calculation" persistable="1" isFixedValue="0" formula="Za1XakmX4Ua6-nklDUbrjw" dim="Dimensionless" quantityType="0" mode="Logical">
-                  <Children>
-                    <Parameter id="TkDlTULlpk2zhr-5Bxd9TA" name="Percentile" persistable="0" isFixedValue="0" formula="DCD2HC-9cEOG0yozXHwzXQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="_K-NS5LBYECns4bxhM7QVA" name="Mean" persistable="0" isFixedValue="0" formula="Z5kAhXrtT0ijQPnjlRZ2Xg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="IVSuy1LVBk6KHlIxgQ3Wyg" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" formula="hv-CppnNKUWX1dDn9e3aSw" dim="Dimensionless" quantityType="0" />
-                  </Children>
-                </DistributedParameter>
-                <DistributedParameter id="rJX0IXR74UmYn3p897uZxQ" name="GFRmat" description="Mature value for GFR in a healthy adult individual weighing 70 kg (=117 mL/min)" persistable="1" isFixedValue="0" formula="Nu2IXBFcmkatJiBnMt4D1g" dim="Flow (volume)" quantityType="0" mode="Logical">
-                  <Children>
-                    <Parameter id="TUiJRODsEUKPm9iuUYtEhw" name="Percentile" persistable="0" isFixedValue="0" formula="cqCy0jdBtkS6TPrRk0bjQQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="iqWqv1AmGE2rdIInflHUwQ" name="Mean" persistable="0" isFixedValue="0" formula="BKeVGe_pqka7-o5qpfUI2w" dim="Flow (volume)" quantityType="0" />
-                    <Parameter id="pCytIweYzUOXl_Q2o0peug" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" formula="KftebjnWeUyXDSJtK09JPg" dim="Flow (volume)" quantityType="0" />
-                  </Children>
-                </DistributedParameter>
-                <DistributedParameter id="do8acol3kUes2cHQqOaqGg" name="Specific blood flow rate" description="Blood flow rate normalized to the organ volume" persistable="1" isFixedValue="0" formula="vAEf64rVyESwQUH54vpTKw" dim="Flow (volume) per organ weight" quantityType="0" mode="Logical">
-                  <Children>
-                    <Parameter id="ZrYaZqaF2ka4XeLu2lkykA" name="Percentile" persistable="0" isFixedValue="0" formula="zfRnLvdz6ki1D3H4D9GWuQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="5Q_CmjR1YkSKcu889tTmAw" name="Mean" persistable="0" isFixedValue="0" formula="W1Ff6vhtUkW3XBv9yE4FTw" dim="Flow (volume) per organ weight" quantityType="0" />
-                    <Parameter id="N8DaTqcS20COvaeMkrU4gg" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" formula="SAibMZKfk0CM0-WqbVOHMA" dim="Flow (volume) per organ weight" quantityType="0" />
-                  </Children>
-                </DistributedParameter>
-                <Container id="plC6riLj_Uy-xFs0o2xqbQ" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Plasma" />
-                    <Tag value="Kidney" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="YUuMYdsdak-UdMyZ9ecQqA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="owgI66XQcE2ClB4BHV50ew" dim="Volume" quantityType="0" />
-                    <Parameter id="wnEssIQvL02RjnxTHIsdyQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="rbp4e7PXpUyuD1ZtA8Ocxw" dim="Volume" quantityType="0" />
-                    <MoleculeAmount id="ldw3pQzm0EybvyXjw2rU6Q" name="Drug" icon="Drug" persistable="0" isFixedValue="0" formula="zlVHxcd4gEOgzX8EXx9ECA" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="UxG4QYLiOUyepVmhMUuDYw" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Parameter id="LMV72czKD0q1a4v3COftbg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="8lDdZFBedECpGupQuaY0Kw" dim="Dimensionless" quantityType="0" />
-                        <Observer id="GVmgoHpKn0KqSktgqANonQ" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Drug, Observer" />
-                      </Children>
-                    </MoleculeAmount>
-                    <MoleculeAmount id="M3hh-3i-5EeX8B15mxhksA" name="Cyp" icon="Enzyme" persistable="0" isFixedValue="0" formula="wb5yCXJZxUeVY_7iSBmoSg" dim="Amount" quantityType="Enzyme" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="ILqCFRnT0EGu-QcYbrGd9w" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" formula="glJ7NiwmyU6Jq9ib19uJpw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="y4D68C3StU2tlf6c7BREbg" name="Relative expression out." description="Relative Expression that will be used in the simulation" persistable="0" isFixedValue="0" formula="GtBZCb_uvUKgURPKDkyZKA" dim="Fraction" quantityType="0" />
-                        <Parameter id="lRDoUubYW06_T5Bzf1R5hQ" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" persistable="0" isFixedValue="0" formula="Qv2OyMi-nU-kPqJ48WVuVw" dim="Fraction" quantityType="0" />
-                        <Parameter id="64KSM9ye8kqB5P0imdc9rA" name="Relative expression" description="Relative expression" persistable="0" isFixedValue="0" formula="iUzjEbj_NkSh4u8TNBhFgQ" dim="Fraction" quantityType="0" />
-                        <Parameter id="dRQc4Wv-QE6Q2z8NlIKFhg" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Observer id="e1lbuV8bKE2l0Px4vqUfWA" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Enzyme, Observer" />
-                      </Children>
-                    </MoleculeAmount>
-                    <MoleculeAmount id="q2TtzkJcGUa1SIDtWpk5Hw" name="Drug-Cyp Metabolite" persistable="0" isFixedValue="0" formula="lbugr_g9rk2jWwy6WyHFhQ" dim="Amount" quantityType="Metabolite" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="0FYPXsc3aEGbfoT28DMeiQ" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Observer id="H_gti2288UGuiwxMVmqkRg" name="Fraction of dose" description="Metabolized fraction of administered dose" persistable="1" isFixedValue="0" formula="aUoTQ3n3a0OShljd8bUj3w" dim="Fraction" quantityType="Metabolite, Observer" />
-                      </Children>
-                    </MoleculeAmount>
-                    <Reaction id="fIWj3GqmqUOhf9RTD5m3uA" name="Cyp-ME" icon="Metabolism" mode="Logical" containerType="Other" dimension="Dimensionless" formula="NrKgrsKmwkiGET1q7OIPYg">
-                      <Educts>
-                        <ReactionPartner stoichiometricCoefficient="1" partner="ldw3pQzm0EybvyXjw2rU6Q" />
-                      </Educts>
-                      <Products>
-                        <ReactionPartner stoichiometricCoefficient="1" partner="q2TtzkJcGUa1SIDtWpk5Hw" />
-                      </Products>
-                      <ModifierNames>
-                        <ModifierNamesChild>Cyp</ModifierNamesChild>
-                      </ModifierNames>
-                    </Reaction>
-                  </Children>
-                </Container>
-                <Container id="C7mUPb7PDkWnMGdSpKh67Q" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="BloodCells" />
-                    <Tag value="Kidney" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="PWUPl9mAVkq4v3eF_kXSTA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="owgI66XQcE2ClB4BHV50ew" dim="Volume" quantityType="0" />
-                    <Parameter id="IQ9sxGfVCEqAgksV4zQkPQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="tFZiRJ-Sv0qf0gsV7ycmYw" dim="Volume" quantityType="0" />
-                    <MoleculeAmount id="hUEhZ6ECiEuzm7PPeH7rQw" name="Drug" icon="Drug" persistable="0" isFixedValue="0" formula="GZOtRtKYeEKE8fGnRWC7mg" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="w05jNduvQ0q-VEgoRit7ag" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Parameter id="7RxPwIGt5UW_TiY93UvaIQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="xnw0zMedY023vpZ9Hb-Klg" dim="Dimensionless" quantityType="0" />
-                        <Observer id="-6no5u6sfkuUDPZHDugGZA" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Drug, Observer" />
-                      </Children>
-                    </MoleculeAmount>
-                    <MoleculeAmount id="aUZdhCwiNkqxDQZyM6f2Zw" name="Cyp" icon="Enzyme" persistable="0" isFixedValue="0" formula="wb5yCXJZxUeVY_7iSBmoSg" dim="Amount" quantityType="Enzyme" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="nXigSc1Nx06FHNsaQZg92Q" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" formula="jmJuVTJ_NkSKeakq_gJLaw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="7zfw1V067U6xSoh6-2MOqA" name="Relative expression out." description="Relative Expression that will be used in the simulation" persistable="0" isFixedValue="0" formula="GtBZCb_uvUKgURPKDkyZKA" dim="Fraction" quantityType="0" />
-                        <Parameter id="m3AEBoTi-Eedy0ScHa18HA" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" persistable="0" isFixedValue="0" formula="FTxLv_b4CkKigLwWdcA4xg" dim="Fraction" quantityType="0" />
-                        <Parameter id="5tPfIjK9eE2-4n_33xAr9g" name="Relative expression" description="Relative expression" persistable="0" isFixedValue="0" formula="_J3C13ewoUatoCS2w-zxeg" dim="Fraction" quantityType="0" />
-                        <Parameter id="35ADHyrXBUKZdhVRCKvPTg" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Observer id="dT0USoo9ik-8ouBCpUfmjg" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Enzyme, Observer" />
-                      </Children>
-                    </MoleculeAmount>
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-                      <Educts>
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-                      </Educts>
-                      <Products>
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-                      </Products>
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-                <Container id="tOT926UGpEGOdbLuY_IdDw" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Interstitial" />
-                    <Tag value="Kidney" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="62EGy00JlUiLq-6evmvHTA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="owgI66XQcE2ClB4BHV50ew" dim="Volume" quantityType="0" />
-                    <Parameter id="aNj-rGlBC0CizpCgcDdTxg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="4VSppd3W3E6-12kllCJ0Mg" dim="Volume" quantityType="0" />
-                    <Parameter id="6L79J3RPik-ysBir3BdeNg" name="pH" description="pH" persistable="0" isFixedValue="0" formula="tKjHIxsi60KoHEPhXQBZrw" dim="Dimensionless" quantityType="0" />
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-                        <Parameter id="zG9FM8J5fk6K8rmRvgM5jw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="zCuJqpTCl0yeDsYoqPwLDQ" dim="Dimensionless" quantityType="0" />
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-                    <Parameter id="f73hjkSadE6-mEdtBEI7mA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="3l84whkuX0S7xUUHglUQpg" dim="Volume" quantityType="0" />
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-                        <Parameter id="8jJFSR0ckEm_-MbxDKxNYQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="428n6PzZIkaOqKA1GOrRpw" dim="Dimensionless" quantityType="0" />
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-                        <Parameter id="imqTY-SkWEyqMPaOTNsP5Q" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" formula="1VUxlvkYq02UPZq_ZIhf7Q" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="X2R7IrpT00a6529ciWRaMw" name="Relative expression out." description="Relative Expression that will be used in the simulation" persistable="0" isFixedValue="0" formula="GtBZCb_uvUKgURPKDkyZKA" dim="Fraction" quantityType="0" />
-                        <Parameter id="NLtYdB7F20-7-zfuKXLHYw" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" persistable="0" isFixedValue="0" formula="3qCA-KCagkGaZ7zYs_wxOA" dim="Fraction" quantityType="0" />
-                        <Parameter id="pdFE2a8zuUev2dVWJv1MzQ" name="Relative expression" description="Relative expression" persistable="0" isFixedValue="0" formula="Bac9deOr-ESI9qnVDY3wpw" dim="Fraction" quantityType="0" />
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-                        <Parameter id="alFhCmjRr0G0NMIYzSSJlw" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
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-                      <Educts>
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-                  <Tags>
-                    <Tag value="Urine" />
-                    <Tag value="Kidney" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="RhAB5wXzV0qrKRQb0MsE-w" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="x4bDymCSfUWUIPUeXq-uWw" dim="Volume" quantityType="0" />
-                    <MoleculeAmount id="-nuQjeuN0UK4NAvFfBvG9g" name="Drug" icon="Drug" persistable="0" isFixedValue="0" formula="XAdWrpcSZEqusW6kynqGoQ" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1">
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-                        <Parameter id="tqlXWleno0-GfDsvIx4AHg" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
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-                        <Observer id="AUgXsTPikUSw2X-rRLrD1w" name="Fraction excreted" description="Fraction Excreted" persistable="1" isFixedValue="0" formula="aUoTQ3n3a0OShljd8bUj3w" dim="Fraction" quantityType="Drug, Observer" />
-                      </Children>
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-                <Container id="o8iVilKsJUGCbchv9K4kxQ" name="Drug" mode="Logical" containerType="Molecule">
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-                    <Observer id="ebMxy91vYECdD_UiDdE9jQ" name="Interstitial Unbound" description="Interstitial Unbound" persistable="1" isFixedValue="0" formula="sb2EI4hIhEWxy5ZYMY2QFw" dim="MolarConcentration" quantityType="Drug, Observer" />
-                    <Observer id="fSZbqzBL80KVrrI6tzuAQg" name="Intracellular Unbound" description="Intracellular Unbound" persistable="1" isFixedValue="0" formula="F5kFVlFTnEmJToE6fKssfA" dim="MolarConcentration" quantityType="Drug, Observer" />
-                    <Observer id="xN8-i6Hn5UOaki2-GKXioA" name="Tissue" description="Tissue" persistable="1" isFixedValue="0" formula="wztK_G9P_0mMbsEE9LSVMw" dim="MolarConcentration" quantityType="Drug, Observer" />
-                  </Children>
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-              <Tags>
-                <Tag value="Lumen" />
-              </Tags>
-              <Children>
-                <Parameter id="J4TJkRvpXkS5fQ94PBL-Fw" name="OralApplicationsEnabled" description="Enables/disables all transports between mucosa and lumen" persistable="0" isFixedValue="0" formula="gzLadla4DEu6Ef-KAhlEtQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="fuf8rOo3iUGspY3ZsVn4Jg" name="Paracellular absorption sink condition" description="Flag for conditions of the environment for paracellular absorption: 1= no sink condition, 0 = sink condition" persistable="0" isFixedValue="0" formula="4VPnf3d4206qqddljztB7w" dim="Dimensionless" quantityType="0" />
-                <Parameter id="ea1RPl-7dEOvHS4J3Ow2Ng" name="Transcellular absorption sink condition" description="Flag for conditions of the environment for transcellular absorption: 1=no sink condition, 0=sink condition" persistable="0" isFixedValue="0" formula="aXhcbNJgukaHbcqBA-UnXw" dim="Dimensionless" quantityType="0" />
-                <Container id="dCtqsinD-EmmzbRUUa2_NQ" name="Stomach" description="Stomach" icon="Stomach" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Stomach" />
-                    <Tag value="Lumen" />
-                    <Tag value="LumenSegment" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="j-1MAYFVxkmTf4ADFD86Qw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="owgI66XQcE2ClB4BHV50ew" dim="Volume" quantityType="0" />
-                    <Parameter id="tg1c7G2VrkOLALLidNQX-w" name="Volume (gut wall)" description="Volume of the gut wall" persistable="0" isFixedValue="0" formula="1JjHOu_qXUCfLrDZjfqvTA" dim="Volume" quantityType="0" />
-                    <Parameter id="HAqHV5M1FkmkvtvTUZpQdQ" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" persistable="0" isFixedValue="0" formula="SdN69bnvNEKeuk8z2n3lGQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="5yTsT73gAkyUn_KEV7SY6g" name="FillLevelFlag" description="Fill Level Flag" persistable="0" isFixedValue="0" formula="pBby0d8e50ijLxI1Zd-y8A" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="A6JQfTvYe0OnuewjRjS7Nw" name="Geometric surface area" description="Geometric surface area of GI segment" persistable="0" isFixedValue="0" formula="ngGNoTJOo0KP78BsUQle0g" dim="Surface" quantityType="0" />
-                    <Parameter id="rssSDtDd50SwjkgJnQ_UmQ" name="GET of non-disintegrated moiety" description="Gastric emptying time of the non-disintegrated moiety" persistable="0" isFixedValue="0" formula="FX_P24RTUEC9YKtlxpzzRg" dim="Time" quantityType="0" />
-                    <Parameter id="rPo6LyrNFkenG9Dwix0bDQ" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" persistable="0" isFixedValue="0" formula="T1_Bp6o5TEq4uMSB1-mJMg" dim="InversedTime" quantityType="0" />
-                    <Parameter id="PJPxOE4zXEiP6TS8XksK-w" name="Liquid" description="Liquid" persistable="0" isFixedValue="0" formula="R6kHqMVgX0GtvICqeL6FFw" dim="Volume" quantityType="0" rHSFormula="zqQHt9MvE0WUCy0iK_NICA" />
-                    <Parameter id="G56TlClxF0yI7eK297rkvw" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" persistable="0" isFixedValue="0" formula="n2nnssTKP02C1pZhcA7Rtw" dim="Rate" quantityType="0" />
-                    <Parameter id="i683fMPx2kS_J8A--_odYw" name="pH" description="pH" persistable="0" isFixedValue="0" formula="Ym6fOXDscESkHVS4FPqwJw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="DIC19uXdQkmZbG7lSZoTUQ" name="Secretion of liquid" description="Rate of liquid inflow" persistable="0" isFixedValue="0" formula="cU32MrCG9kqvf1Ue9oLOiQ" dim="Flow (volume)" quantityType="0" />
-                    <Parameter id="cRa1F47KmEinIS8hhPqFNw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="xhED215POEuWycLJEijJ4Q" dim="Volume" quantityType="0" />
-                    <Parameter id="m2jUgmUNr02gd_YQ-tIsWw" name="Absorption of liquid" description="rate of liquid outflow" persistable="0" isFixedValue="0" formula="JjjUYAKMikiAsinUYb_hNw" dim="InversedTime" quantityType="0" />
-                    <Parameter id="lY3Sv7pghUWamFbDMzmNZQ" name="pH in fasted state" description="pH in fasted state" persistable="0" isFixedValue="0" formula="wHEWD4_S5UuZ0DNRYuCDoA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="o506C1JBvUW86mpLrN0iqw" name="Inverse rate of inflow of liquid into stomach" description="Inverse rate of inflow of liquid into stomach" persistable="0" isFixedValue="0" formula="h2NgV8PvWkOnc7vB53xsPQ" dim="Time" quantityType="0" />
-                    <Parameter id="u5IVJ1oHfU-vC-4WCMy_Cw" name="Gastric emptying time" description="Gastric emptying time" persistable="0" isFixedValue="0" formula="SHZFg1KtmUOqwqVRCKkaOA" dim="Time" quantityType="0" />
-                    <Parameter id="a0OXM9DGCEuQYazW3ZOnsg" name="pH in fed state" description="pH in fed state" persistable="0" isFixedValue="0" formula="KeeHTlkGEE6WyzJ3fJH8xA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="1P_TlzzQEkm0GGoLO3RTHQ" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" persistable="0" isFixedValue="0" formula="Y5aSDkMVEUqVaqgqaDdL2Q" dim="Fraction" quantityType="0" />
-                    <Parameter id="hLMuMNMSf0iAKsiZQ22RTw" name="Thickness of gut wall" description="Thickness of Gut Wall" persistable="0" isFixedValue="0" formula="l8p6ZOnNKkCPg_-hvpD8Jg" dim="Length" quantityType="0" />
-                    <DistributedParameter id="0UQ5hoF-9024E0JjUM9MDw" name="Distal radius" description="Distal radius of intestinal segment" persistable="1" isFixedValue="0" formula="LCv_YhcwkkG4wdJPYaJ24w" dim="Length" quantityType="0" mode="Logical">
-                      <Children>
-                        <Parameter id="BxMoVFUpBUKJpRnzTx1a3w" name="Percentile" persistable="0" isFixedValue="0" formula="V76OTE3U6Ei6GBnwyjAYlg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="tvqBd1YpDkK6lFvlP6Twag" name="Mean" persistable="0" isFixedValue="0" formula="7pqVQcPe-EGCwBLTAvWOKQ" dim="Length" quantityType="0" />
-                      </Children>
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-                    <DistributedParameter id="m0fUH8q1LEWQOWOL9vyt_Q" name="Proximal radius" description="Proximal radius of intestinal segment" persistable="1" isFixedValue="0" formula="jckKCf_PeUyRpUHsnNLmwA" dim="Length" quantityType="0" mode="Logical">
-                      <Children>
-                        <Parameter id="KqSS6M4nTU6JA9EKAlSA4g" name="Percentile" persistable="0" isFixedValue="0" formula="qR_AFodsSUCtYZM65HWFDA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="TBYau7pL0E6G6cgMHVxeJw" name="Mean" persistable="0" isFixedValue="0" formula="faZj_1GC80ekS7BTZonZBA" dim="Length" quantityType="0" />
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-                    <DistributedParameter id="Xp9v33tio0uspssdzoR27Q" name="Length" description="Length" persistable="1" isFixedValue="0" formula="Rls5EvvfG0ybNuW8d3G7tQ" dim="Length" quantityType="0" mode="Logical">
-                      <Children>
-                        <Parameter id="lGp8k2U0rUS70rQD9twGzA" name="Percentile" persistable="0" isFixedValue="0" formula="_jdZeW5fK0adwuuQO8Qnyw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="59jUJA1GeUexxbGOU1h2Gw" name="Mean" persistable="0" isFixedValue="0" formula="AoFGg5KN4kyINrvnZL682Q" dim="Length" quantityType="0" />
-                      </Children>
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-                    <MoleculeAmount id="CzE8be5tsEWm86tdh6X94Q" name="Drug" icon="Drug" persistable="0" isFixedValue="0" formula="mdNZgB-loEy8CwDMgSrgkw" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="XpihZ-VQ1EGZ6uuC8a6mzg" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Parameter id="I3-uoTd6TU6lMnDZd345Mg" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="Qmuyl3X8BU26BM9WKJg9Ww" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="-7K52GDU0Ee3hwHTdIwMtA" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="bvDk8fVZB0u7YzCJWBPa5g" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="mNr14pw1vEqR2U4w8Qvm6Q" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="BdCLSost8Uue3XDtpLAuJA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="A8gA0VGcyU2YotCH4EcCUA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="Yn7C285HukurRpbO8rRrCQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="iykbqps8MkSCI4Tmp3F1lg" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="8ZOsmawKHUeQHinznCfxlg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="aLWoLcYt90-4RbRLCQv1Tw" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="PtlsiOrtqU2isza3dTBPWA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="W9cs3p_zikasO7wIROpyvQ" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="K3nK5_PbYUa46cgk2AGXhw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="UG2b-1c9uE-wfMtpVpLGiA" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" persistable="0" isFixedValue="0" formula="g8Jw_TtrXE6c98NC4YLM5g" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="pL0HhPpWIUyxjcWCW5Repg" name="Solubility" description="Solubility" persistable="0" isFixedValue="0" formula="GqZHbIqWaEmTBEx56brOxg" dim="Concentration" quantityType="0" />
-                        <Parameter id="-Ygp6NEAMEKMChmGhXMNZg" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="BaIBjcyJr02PFcJGmsYudg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="wb4hZMM0IkKXa8AnNA0hgw" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="sVDTITeOxUSEwu6xTbiq4A" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="GdTLVXSTzkacPZuqkijPrQ" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="eeibDEo7zUmvsFDTbpvKOw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="Opu0s6O7o0u0vhUg8tTRFA" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="9hLMZSoQAE6qhhktt-T8-g" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="uIpPETKvq0OSeQ4i_gtrVg" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="mJn2ZMMkeUqDhWrvFCb5nw" dim="Dimensionless" quantityType="0" />
-                        <Observer id="VaUnrVpRbEOAkdThX3aq7w" name="Concentration in lumen" description="Concentration of the molecule in lumen" persistable="1" isFixedValue="0" formula="j43RhC6Wv0W0HJ9_uFMTPw" dim="MolarConcentration" quantityType="Drug, Observer" />
-                      </Children>
-                    </MoleculeAmount>
-                    <MoleculeAmount id="3BAP1eiBuEqKQhDs0lmEOA" name="Cyp" icon="Enzyme" persistable="0" isFixedValue="0" formula="wb5yCXJZxUeVY_7iSBmoSg" dim="Amount" quantityType="Enzyme" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="lekCYfXsfEmTF_bLEz2Gvg" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" formula="h4WX3a8VAUmJmRtpEA5Sow" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="DNmq8PP0Q0SVnzAGOx_7ig" name="Relative expression out." description="Relative Expression that will be used in the simulation" persistable="0" isFixedValue="0" formula="GtBZCb_uvUKgURPKDkyZKA" dim="Fraction" quantityType="0" />
-                        <Parameter id="O0_QDl8geEW7wGlO73Jymw" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" persistable="0" isFixedValue="0" formula="JeY7nfg7FUSysVla-kNK0Q" dim="Fraction" quantityType="0" />
-                        <Parameter id="k28rI8L4Bk-KlUQBMWGT4A" name="Relative expression" description="Relative expression" persistable="0" isFixedValue="0" formula="3lAJFGvmx0mlLKLSbYiUQA" dim="Fraction" quantityType="0" />
-                        <Parameter id="pBqLLreRM0ycf6DzGVkOwg" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                      </Children>
-                    </MoleculeAmount>
-                    <MoleculeAmount id="SBZxiieOmkSTwnIV8DzYeg" name="Drug-Cyp Metabolite" persistable="0" isFixedValue="0" formula="uWiGmhEnD0a7adW7xNp9tA" dim="Amount" quantityType="Metabolite" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="46AmsRRPBU-4jrU9HiT7Qw" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Observer id="Dw8pKqL5NUaG5zghc-G2IQ" name="Fraction of dose" description="Metabolized fraction of administered dose" persistable="1" isFixedValue="0" formula="aUoTQ3n3a0OShljd8bUj3w" dim="Fraction" quantityType="Metabolite, Observer" />
-                      </Children>
-                    </MoleculeAmount>
-                    <Reaction id="HnS0TC9wUkiPG2Z5ClXydw" name="Cyp-ME" icon="Metabolism" mode="Logical" containerType="Other" dimension="Dimensionless" formula="NrKgrsKmwkiGET1q7OIPYg">
-                      <Educts>
-                        <ReactionPartner stoichiometricCoefficient="1" partner="CzE8be5tsEWm86tdh6X94Q" />
-                      </Educts>
-                      <Products>
-                        <ReactionPartner stoichiometricCoefficient="1" partner="SBZxiieOmkSTwnIV8DzYeg" />
-                      </Products>
-                      <ModifierNames>
-                        <ModifierNamesChild>Cyp</ModifierNamesChild>
-                      </ModifierNames>
-                    </Reaction>
-                  </Children>
-                </Container>
-                <Container id="lZLwaVLayEa1f_nNQ00DVQ" name="Duodenum" description="Duodenum" icon="Duodenum" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Duodenum" />
-                    <Tag value="Lumen" />
-                    <Tag value="LumenSegment" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="ET0kzFvGcEGAaejTpEIpxQ" name="Distal radius" description="Distal radius of intestinal segment" persistable="0" isFixedValue="0" formula="R46ArBLQ1US2Gb1bCChBmA" dim="Length" quantityType="0" />
-                    <Parameter id="7-EyDkULKkC3QYfBlGLU3Q" name="FillLevelFlag" description="Fill Level Flag" persistable="0" isFixedValue="0" formula="pBby0d8e50ijLxI1Zd-y8A" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="4_o4ieLC9kK0bMcA1-Qmqw" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" persistable="0" isFixedValue="0" formula="SdN69bnvNEKeuk8z2n3lGQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="UXnVUz541k2MbYxgYfGayw" name="Geometric surface area" description="Geometric surface area of GI segment" persistable="0" isFixedValue="0" formula="ngGNoTJOo0KP78BsUQle0g" dim="Surface" quantityType="0" />
-                    <Parameter id="4e2v3Rrl-kmzmzgkyEmfAA" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" persistable="0" isFixedValue="0" formula="4hmQ01ZWN0WLlSsVGuDzvQ" dim="InversedTime" quantityType="0" />
-                    <Parameter id="cowF6hHz0EWrdewe-CvI3g" name="Length" description="Length" persistable="0" isFixedValue="0" formula="GC0lSgOyJUOIXmPp5q-wcg" dim="Length" quantityType="0" />
-                    <Parameter id="ryk1RnY5O0-7GUyYzXe2uA" name="Liquid" description="Liquid" persistable="0" isFixedValue="0" formula="R6kHqMVgX0GtvICqeL6FFw" dim="Volume" quantityType="0" rHSFormula="i6wXbpHGpkS7eZaSfkezvw" />
-                    <Parameter id="hAemk1QJEEirrDdOfrHz0A" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" persistable="0" isFixedValue="0" formula="RINzyaAeV0WpD8gvu7bSRw" dim="Rate" quantityType="0" />
-                    <Parameter id="ujiI0RK-jkCfP05sHNGr-Q" name="Proximal radius" description="Proximal radius of intestinal segment" persistable="0" isFixedValue="0" formula="bOSpmtTi7k2o4j709TGn3A" dim="Length" quantityType="0" />
-                    <Parameter id="gk32S3Eem0OU1z8Y5mkQKw" name="Thickness of gut wall" description="Thickness of Gut Wall" persistable="0" isFixedValue="0" formula="CrwFKdc0AkmmncutO67a1A" dim="Length" quantityType="0" />
-                    <Parameter id="DlXrOuyEbkq6xYwFP3Wh9w" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="xhED215POEuWycLJEijJ4Q" dim="Volume" quantityType="0" />
-                    <Parameter id="FuSqEtuZJUGP_SPSPWCfeQ" name="Volume (gut wall)" description="Volume of the gut wall" persistable="0" isFixedValue="0" formula="1JjHOu_qXUCfLrDZjfqvTA" dim="Volume" quantityType="0" />
-                    <Parameter id="LXE2Ud-0skqLelrCP2jHJQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="owgI66XQcE2ClB4BHV50ew" dim="Volume" quantityType="0" />
-                    <Parameter id="FwRnn19PkUaJEyHOMyfkFQ" name="Secretion of liquid" description="Rate of liquid inflow" persistable="0" isFixedValue="0" formula="5WQeOGtAykeKz1CSAsMldQ" dim="Flow (volume)" quantityType="0" />
-                    <Parameter id="zFwMCKYgQUCcWHKIAMvgrw" name="Absorption of liquid" description="rate of liquid outflow" persistable="0" isFixedValue="0" formula="KPUtrqpH2UG833UP70HC0g" dim="InversedTime" quantityType="0" />
-                    <Parameter id="f4f7diz-nEOAEfM2z33gkQ" name="pH" description="pH" persistable="0" isFixedValue="0" formula="Is_v39Er1kivlXSWs9QFuQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="2jXmB1PiA0inXZWep3u_qg" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" formula="npQzHZVleUGc8APoYXly2A" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="8ZQfQpt4jkyrzrUWrIWnlA" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" persistable="0" isFixedValue="0" formula="A6IjeF4Tb0SzIYGv1u3CPQ" dim="Fraction" quantityType="0" />
-                    <Parameter id="fUAof2MR202r_13hgo0uHQ" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="xMFDBrt4G0OSh1mRl0_5JA" dim="Length" quantityType="0" />
-                    <Parameter id="m8BHxRdBHku9Jy1chMN-aQ" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" formula="qUXHym6KHkWauwen3TTOMA" dim="InversedLength" quantityType="0" />
-                    <Parameter id="9Ljqv-Hy8EK9y6GMUnbBwg" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" formula="aHs3IKwgMEGO6wqylJc5oA" dim="Length" quantityType="0" />
-                    <Parameter id="qEgKNlDwTU6B-Rs5w2xYng" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="IUYSQ2iHDEqxFJiFgM3rig" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="XmDoK0KJGkWdf-ZzQP6rDw" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="k2-qxBDA4U2JzyV_Av7eGw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="gCcqVKuCz0qtNqSKJkiJNA" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="cDs3zqGpDUeRjd_XTKLwKw" dim="Length" quantityType="0" />
-                    <Parameter id="WiDBNZ0gVUWO57kpxoNYEg" name="Microvilli factor" description="Microvilli factor" persistable="0" isFixedValue="0" formula="UYyN3yue9kK9weFgTnnL8A" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="zKEhU8jHG0Cg9QJW5Nb0QQ" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="Q60kX2DQMUy0WvnJzbIGoQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="7nOH35ZVZEiRjsFSgOFPuw" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="1n491-BL9U-0iU79jrU6UA" dim="Length" quantityType="0" />
-                    <Parameter id="r4c3xVtkJEigRlQive6OXg" name="Intestinal transit rate" description="Transit rate along intestinal segments" persistable="0" isFixedValue="0" formula="LeWt6Mq44EatyOu-R9smsA" dim="InversedTime" quantityType="0" />
-                    <Parameter id="zlCeVZL-E0uh98YIbtXNqw" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" formula="QTXZlUzN6UuT-Z4Ha2YOuw" dim="Length" quantityType="0" />
-                    <MoleculeAmount id="Cp9CcV7Ov06YVtSbGuudTw" name="Drug" icon="Drug" persistable="0" isFixedValue="0" formula="JNaALLzRdEOYor4q9N21og" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="X_0JB0hgwU2Rq7jv6WWLqA" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Parameter id="cNO1C4aTRUOs5xFRq-Jn0g" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="6rhmjqGvAUm_FRMCSCNCWA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="Zs2O1kmHTUSNn5TKL-9-eQ" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="_QTJvIWzCk2Mhxo6wsLSiA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="bAJNN2auokq_9TCo7oDkVQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="vAHca0Ly_EGokO4QYu-DzQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="9oDo_YhlqkCwGBbYk6F_kQ" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" persistable="0" isFixedValue="0" formula="na4qgFaVckSLuIOxzXtasw" dim="Amount" quantityType="0" rHSFormula="zOZJc8VHG0KJZo3Kz48UOQ" />
-                        <Parameter id="GwBQEEoKt0eJyGJVQXUttg" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="nDRV00GWfU-_UHLTabvi-w" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="iTvlIfsMD0mwp2ka4EtTPQ" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="h3-k6f_VWUWrwwe2yANnOw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="qHyKnvue80Kpk9wemoEQPw" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="5o6ix2VzlU29PJZ_Y8u16w" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="E_6lbJWFFUep5XNlCxx-Dw" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" persistable="0" isFixedValue="0" formula="V3XFulu3QUW79_4GPI00Uw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="W2FhfY8rzUukq_HIiAse5A" name="Solubility" description="Solubility" persistable="0" isFixedValue="0" formula="DEW1oddsA0OiqxpwK-2veQ" dim="Concentration" quantityType="0" />
-                        <Parameter id="dpESGj6aI0ePadBoIAoOKA" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="yBVUYr80gkmwncroXCU3dw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="ca-_Qc7UvUa9oPTZLmDF9g" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="PqL7HhxnwE-40HPGkzNpGQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="XCJjmBWekUGOwktM-TmbZw" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="T0vN1CkDn0uC5gb66p82kA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="3HOxxSdHXE2QneG3JwVXkA" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="FGTF1bNhQkKrNFRpJdWTCA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="GcMCU8OjxkCwMQVk7p1Y5g" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="99Hdvix3TU6ZE9YtVf6eTQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="FK8qGYoWjUyPbgtOKwhrGQ" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="ajOB3TDKM0SitG8Iji3dXg" dim="Dimensionless" quantityType="0" />
-                        <Observer id="WlPrq6IwVECgEDDpJ6oqwg" name="Concentration in lumen" description="Concentration of the molecule in lumen" persistable="1" isFixedValue="0" formula="j43RhC6Wv0W0HJ9_uFMTPw" dim="MolarConcentration" quantityType="Drug, Observer" />
-                        <Observer id="T90M6KDV6EyCa1r9i7OQ1Q" name="Fraction of oral drug mass absorbed into mucosa segment" description="Fraction of oral drug mass absorbed into mucosa segment" persistable="1" isFixedValue="0" formula="5nbLuxyKsUig2MN-jcY9IA" dim="Fraction" quantityType="Drug, Observer" />
-                      </Children>
-                    </MoleculeAmount>
-                    <MoleculeAmount id="OsIXLtXSOkC215uFZW8RGw" name="Cyp" icon="Enzyme" persistable="0" isFixedValue="0" formula="wb5yCXJZxUeVY_7iSBmoSg" dim="Amount" quantityType="Enzyme" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="rf9b93C5GkKe6IORwLAkgQ" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" formula="Ib0Dfky6M02JYfCR4hwAaA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="U3wxMRjdHE-KHFFwgJpT4Q" name="Relative expression out." description="Relative Expression that will be used in the simulation" persistable="0" isFixedValue="0" formula="GtBZCb_uvUKgURPKDkyZKA" dim="Fraction" quantityType="0" />
-                        <Parameter id="_9fZ3jvs6Ua8ssz4U2EI1Q" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" persistable="0" isFixedValue="0" formula="xIPt1ZZHRE-Bb-MOMPVhjA" dim="Fraction" quantityType="0" />
-                        <Parameter id="RtCCU6YcpU6IkDsqMHVGVQ" name="Relative expression" description="Relative expression" persistable="0" isFixedValue="0" formula="opsO-HgcmESsnLDzRu9BNw" dim="Fraction" quantityType="0" />
-                        <Parameter id="537K1R9cwkOw_APybGOw5g" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                      </Children>
-                    </MoleculeAmount>
-                    <MoleculeAmount id="3lB9Pd1p9UaBeRS28qoD-Q" name="Drug-Cyp Metabolite" persistable="0" isFixedValue="0" formula="GjHoefJJdE2lLbiXQY0lLg" dim="Amount" quantityType="Metabolite" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="YJxhFO97WEiBdJZYxpd5Zg" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Observer id="2lqeQQAmTUugY_dX065x8w" name="Fraction of dose" description="Metabolized fraction of administered dose" persistable="1" isFixedValue="0" formula="aUoTQ3n3a0OShljd8bUj3w" dim="Fraction" quantityType="Metabolite, Observer" />
-                      </Children>
-                    </MoleculeAmount>
-                    <Reaction id="WCUVvUEMN0OnF59aDwl3kQ" name="Cyp-ME" icon="Metabolism" mode="Logical" containerType="Other" dimension="Dimensionless" formula="NrKgrsKmwkiGET1q7OIPYg">
-                      <Educts>
-                        <ReactionPartner stoichiometricCoefficient="1" partner="Cp9CcV7Ov06YVtSbGuudTw" />
-                      </Educts>
-                      <Products>
-                        <ReactionPartner stoichiometricCoefficient="1" partner="3lB9Pd1p9UaBeRS28qoD-Q" />
-                      </Products>
-                      <ModifierNames>
-                        <ModifierNamesChild>Cyp</ModifierNamesChild>
-                      </ModifierNames>
-                    </Reaction>
-                  </Children>
-                </Container>
-                <Container id="T_r3PYDtuUqoyydWMcZ6Ig" name="UpperJejunum" description="Upper Jejunum" icon="UpperJejunum" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="UpperJejunum" />
-                    <Tag value="Lumen" />
-                    <Tag value="LumenSegment" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="Zqb6sFLFu0mRKdxRlIrIaQ" name="Absorption of liquid" description="rate of liquid outflow" persistable="0" isFixedValue="0" formula="t3RAd0LrLEaTx2ci_uqFqA" dim="InversedTime" quantityType="0" />
-                    <Parameter id="2qMb_LSU1EufR3biclFkog" name="Distal radius" description="Distal radius of intestinal segment" persistable="0" isFixedValue="0" formula="R46ArBLQ1US2Gb1bCChBmA" dim="Length" quantityType="0" />
-                    <Parameter id="8nUyK1aGGkCakqYYcTe-Wg" name="FillLevelFlag" description="Fill Level Flag" persistable="0" isFixedValue="0" formula="pBby0d8e50ijLxI1Zd-y8A" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="xR1HbEGsz0mR1miuCRrMbA" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" persistable="0" isFixedValue="0" formula="SdN69bnvNEKeuk8z2n3lGQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="Y4q1PSNjz0qo6JxpFMYoeQ" name="Geometric surface area" description="Geometric surface area of GI segment" persistable="0" isFixedValue="0" formula="ngGNoTJOo0KP78BsUQle0g" dim="Surface" quantityType="0" />
-                    <Parameter id="l3BSAiSvh0mhhxkLiuOO3w" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" persistable="0" isFixedValue="0" formula="UoCC1-a_C0-nr14Dp79UTw" dim="InversedTime" quantityType="0" />
-                    <Parameter id="9uvSgYDmsEuT67eLpxm2Fw" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" persistable="0" isFixedValue="0" formula="RsF-UpFq_keG7CGrmdVzGg" dim="Rate" quantityType="0" />
-                    <Parameter id="5S3Iio62Ck6V-j7SUTN_Tw" name="Length" description="Length" persistable="0" isFixedValue="0" formula="GC0lSgOyJUOIXmPp5q-wcg" dim="Length" quantityType="0" />
-                    <Parameter id="1Xt3UNTPfkmhyIvMbGxEzQ" name="Proximal radius" description="Proximal radius of intestinal segment" persistable="0" isFixedValue="0" formula="bOSpmtTi7k2o4j709TGn3A" dim="Length" quantityType="0" />
-                    <Parameter id="dblzYkcGU0ysUjN1xQor5w" name="Secretion of liquid" description="Rate of liquid inflow" persistable="0" isFixedValue="0" formula="D7Ye2T6dPUako8OV7VAOug" dim="Flow (volume)" quantityType="0" />
-                    <Parameter id="TZcebKqClUOIythjRRo4IA" name="Thickness of gut wall" description="Thickness of Gut Wall" persistable="0" isFixedValue="0" formula="CrwFKdc0AkmmncutO67a1A" dim="Length" quantityType="0" />
-                    <Parameter id="3OtMshxjcUOSH-G5b3Z--Q" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="xhED215POEuWycLJEijJ4Q" dim="Volume" quantityType="0" />
-                    <Parameter id="W6VALvu60UKyAK_gE8wiTg" name="Volume (gut wall)" description="Volume of the gut wall" persistable="0" isFixedValue="0" formula="1JjHOu_qXUCfLrDZjfqvTA" dim="Volume" quantityType="0" />
-                    <Parameter id="yiDO_IeHfkCzVYu0eMwtAw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="owgI66XQcE2ClB4BHV50ew" dim="Volume" quantityType="0" />
-                    <Parameter id="9zPdwwIpX0WwNBcVTV2ewQ" name="Liquid" description="Liquid" persistable="0" isFixedValue="0" formula="R6kHqMVgX0GtvICqeL6FFw" dim="Volume" quantityType="0" rHSFormula="ABlaeASZdk6fKALFPDi3bw" />
-                    <Parameter id="D_kZbgidbE2sU9WFC4GAzQ" name="pH" description="pH" persistable="0" isFixedValue="0" formula="uMG93fRO1UWCEvk6bFXZmw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="bebPeMWhxUK0sTVsI8wHTA" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="wmaU_va-tkucXAGoJ8q_HQ" dim="Length" quantityType="0" />
-                    <Parameter id="5DPYP5-Vv0uE9ZfaXSceOg" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" persistable="0" isFixedValue="0" formula="EkpvdkYXQkOPNpQ6P9RBJw" dim="Fraction" quantityType="0" />
-                    <Parameter id="yJUhtMNqJkeLYNmWp8Xdaw" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" formula="p_cLgFhBpU61k7EStXXyEA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="sH-mH7MWSEqatmVRZ25yPw" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="FdS4mI7Gy0ekjExdx8s2LA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="ZUHLQCtC40iA-ihFTZrb_Q" name="Intestinal transit rate" description="Transit rate along intestinal segments" persistable="0" isFixedValue="0" formula="GiwIg7DOeUyFrCmF8-ZTJw" dim="InversedTime" quantityType="0" />
-                    <Parameter id="qHUyfAztQEq0fGpricUiuA" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" formula="3hJb1B9AHU6ckpjvFGOOeg" dim="Length" quantityType="0" />
-                    <Parameter id="dwPM1WTz9kSVeLTe3PwLlg" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" formula="KpLZYjkBq0qJoNEg7lrmaw" dim="InversedLength" quantityType="0" />
-                    <Parameter id="Kh0YVfqUcUmFHGhGmjiLKQ" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" formula="t-oqKPHqJE6KhUHuXHML-g" dim="Length" quantityType="0" />
-                    <Parameter id="iilThqm73ES22_dakx7i4g" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="hV9NaCGoM0uGKfvvj-3mpQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="KM72dpp940aa9LTxso-cWQ" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="mqRgzWa-7ECV5tdON3lUcA" dim="Length" quantityType="0" />
-                    <Parameter id="XFVCZFKQD0Gvn-taYZQDZQ" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="9MDxrJ3IVEyAp67fuGsdlA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="psDuT09i9Uu2WNTwlpHD_w" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="e08241LEtkCXYxYtgK4oog" dim="Length" quantityType="0" />
-                    <Parameter id="5qOkomeyO0i7EsLoC4zCDg" name="Microvilli factor" description="Microvilli factor" persistable="0" isFixedValue="0" formula="cIypUU28Jk-M3LAmj1QAdA" dim="Dimensionless" quantityType="0" />
-                    <MoleculeAmount id="sY_deNTPkU-udpyOezaONw" name="Drug" icon="Drug" persistable="0" isFixedValue="0" formula="_22I4Eh9MEOG71wFS1tj_Q" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="nmp6fQ5LQ06CIs3CSrImsA" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Parameter id="rNGfXSCfHUCUCR0K_xhnPw" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="0JtLyJw4N0CQPeEr6evL0w" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="HGY3LGMmuUiQQBGNyWzylA" name="Solubility" description="Solubility" persistable="0" isFixedValue="0" formula="sPn0PQIYVUWzd9J2iJOe9Q" dim="Concentration" quantityType="0" />
-                        <Parameter id="43J-S2L1C0qcbwG0zabGDg" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="dsUe_WZOf0CPWGQbCalkcA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="HpoSDORgski1jpZJigBEsA" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="twyJ6BqcwkuOSArrByNk8A" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="NpO1WIudeU6tFtH1LodYHg" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="dIrUtCOG50uRzXULtfkMpQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="PDj6t2Bh9U-peDH3Ewgm4Q" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="REKwB8tikEexPiytQHUZxQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="dNkSjzDJW0yGS5CLfNtiJQ" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="Idjw5iF0iEuIcVX8fFHfUA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="AgOi0iSWmUizhFx4nliYqw" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="amj7I5XxyEafyxwKSB7kNA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="bQUtbg11X0avqeQLHQDxGQ" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="dsYcudbWzUSoHJmPxteT-w" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="Pd6eslHKSEufKbeQbiYr3Q" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="2qkHqueWX0a2Ia7aVPYrDA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="hbt_AUDp00268Dee6iC3yA" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="PGUL87G7rUiyThKXuDDRtw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="JmMlvOwkaEWKDq7wRz_WJg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="Vk85VT9SRU6k8MfCJ8_kcw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="hfTKP6AzB0eCASPgZjWoYw" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" persistable="0" isFixedValue="0" formula="psN2L3rbY0C-eF63Sm92ew" dim="Amount" quantityType="0" rHSFormula="HgpW49moPE-g0lIOLIwjiA" />
-                        <Parameter id="6dO_JYMxd0mJWedkg397_A" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="TXlq6XHmkUeJv8YTuxuTeg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="nZzR9Lw5wUOjaDFnGZrpRA" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" persistable="0" isFixedValue="0" formula="9sowSeHGEkSy4TtxailktQ" dim="Dimensionless" quantityType="0" />
-                        <Observer id="MUgtDeVFZ0ej5m3wu87m8g" name="Concentration in lumen" description="Concentration of the molecule in lumen" persistable="1" isFixedValue="0" formula="j43RhC6Wv0W0HJ9_uFMTPw" dim="MolarConcentration" quantityType="Drug, Observer" />
-                        <Observer id="OqVKRx8gmkOKdAAFFPGMmg" name="Fraction of oral drug mass absorbed into mucosa segment" description="Fraction of oral drug mass absorbed into mucosa segment" persistable="1" isFixedValue="0" formula="5nbLuxyKsUig2MN-jcY9IA" dim="Fraction" quantityType="Drug, Observer" />
-                      </Children>
-                    </MoleculeAmount>
-                    <MoleculeAmount id="WXSaZDw7t0iDxE6endLd7Q" name="Cyp" icon="Enzyme" persistable="0" isFixedValue="0" formula="wb5yCXJZxUeVY_7iSBmoSg" dim="Amount" quantityType="Enzyme" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="iLFEEmhrjkCDRDqJQ9Q5_g" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" formula="8d7iMsn0XUazUaIE_nKmqA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="Dr7XlyZQQUWMhpVBTsYyUg" name="Relative expression out." description="Relative Expression that will be used in the simulation" persistable="0" isFixedValue="0" formula="GtBZCb_uvUKgURPKDkyZKA" dim="Fraction" quantityType="0" />
-                        <Parameter id="di8YUCr8K0ucjIN7n1oqow" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" persistable="0" isFixedValue="0" formula="WLxuJih4bE2AVKElyBwtyw" dim="Fraction" quantityType="0" />
-                        <Parameter id="Z_wkUyUt8kCYhtNy4-Hc_g" name="Relative expression" description="Relative expression" persistable="0" isFixedValue="0" formula="fZ0HViBoTku3DcPtpZJ9Aw" dim="Fraction" quantityType="0" />
-                        <Parameter id="GgX6rQjOzESVVcefUtkkqw" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                      </Children>
-                    </MoleculeAmount>
-                    <MoleculeAmount id="IAZ1Tj9ok0-2CX9VztMEoA" name="Drug-Cyp Metabolite" persistable="0" isFixedValue="0" formula="i46meNmgGESzSRvPbaieVg" dim="Amount" quantityType="Metabolite" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="oLRoFZvy90ivirdQU-cIjA" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Observer id="JNiTm_w79U2WiO0hRYaeDQ" name="Fraction of dose" description="Metabolized fraction of administered dose" persistable="1" isFixedValue="0" formula="aUoTQ3n3a0OShljd8bUj3w" dim="Fraction" quantityType="Metabolite, Observer" />
-                      </Children>
-                    </MoleculeAmount>
-                    <Reaction id="9G60VOG8SUSUBsyRIA2SxQ" name="Cyp-ME" icon="Metabolism" mode="Logical" containerType="Other" dimension="Dimensionless" formula="NrKgrsKmwkiGET1q7OIPYg">
-                      <Educts>
-                        <ReactionPartner stoichiometricCoefficient="1" partner="sY_deNTPkU-udpyOezaONw" />
-                      </Educts>
-                      <Products>
-                        <ReactionPartner stoichiometricCoefficient="1" partner="IAZ1Tj9ok0-2CX9VztMEoA" />
-                      </Products>
-                      <ModifierNames>
-                        <ModifierNamesChild>Cyp</ModifierNamesChild>
-                      </ModifierNames>
-                    </Reaction>
-                  </Children>
-                </Container>
-                <Container id="kIyZFLx3Zka2-n_FBxYOFw" name="LowerJejunum" description="Lower Jejunum" icon="LowerJejunum" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="LowerJejunum" />
-                    <Tag value="Lumen" />
-                    <Tag value="LumenSegment" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="SKECV1o9C0uY7dgaZekrIQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="xhED215POEuWycLJEijJ4Q" dim="Volume" quantityType="0" />
-                    <Parameter id="4VO1A3ZPD0apdXijUtTOeg" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" persistable="0" isFixedValue="0" formula="SdN69bnvNEKeuk8z2n3lGQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="jt9AIQFLf0GjRiUyJpRXxA" name="Absorption of liquid" description="rate of liquid outflow" persistable="0" isFixedValue="0" formula="FHqIFBoT40aLFiOvj7RO4w" dim="InversedTime" quantityType="0" />
-                    <Parameter id="I-wmjlq13U245vGZUbZ21g" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="owgI66XQcE2ClB4BHV50ew" dim="Volume" quantityType="0" />
-                    <Parameter id="nnh50fza1E-IbjtI22HbnA" name="FillLevelFlag" description="Fill Level Flag" persistable="0" isFixedValue="0" formula="pBby0d8e50ijLxI1Zd-y8A" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="e6YaWh-_4kyiiZIR9oRnCQ" name="Volume (gut wall)" description="Volume of the gut wall" persistable="0" isFixedValue="0" formula="1JjHOu_qXUCfLrDZjfqvTA" dim="Volume" quantityType="0" />
-                    <Parameter id="4C4CStf9y0OCtgThA4wbEg" name="Geometric surface area" description="Geometric surface area of GI segment" persistable="0" isFixedValue="0" formula="ngGNoTJOo0KP78BsUQle0g" dim="Surface" quantityType="0" />
-                    <Parameter id="zBDprIUUYkODbmUNWtINjA" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" persistable="0" isFixedValue="0" formula="qOyeDK61a0G1ubfRROj58w" dim="InversedTime" quantityType="0" />
-                    <Parameter id="61BTxu6eKUGV2TnXCNQiJA" name="Length" description="Length" persistable="0" isFixedValue="0" formula="GC0lSgOyJUOIXmPp5q-wcg" dim="Length" quantityType="0" />
-                    <Parameter id="XrPXJ_i9_06MYppu8cHjAw" name="Liquid" description="Liquid" persistable="0" isFixedValue="0" formula="R6kHqMVgX0GtvICqeL6FFw" dim="Volume" quantityType="0" rHSFormula="bkPTDJi1tEOkMgiQWlQhYg" />
-                    <Parameter id="bLpQ1SAoWkiD-pwEqs58wg" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" persistable="0" isFixedValue="0" formula="XOeW3BOI10CCm4KbS4Qd4A" dim="Rate" quantityType="0" />
-                    <Parameter id="6zU_glrWDkOe9y6dIjiFfw" name="Proximal radius" description="Proximal radius of intestinal segment" persistable="0" isFixedValue="0" formula="bOSpmtTi7k2o4j709TGn3A" dim="Length" quantityType="0" />
-                    <Parameter id="A_r9yUxR-ESfCXcDGHFluw" name="Secretion of liquid" description="Rate of liquid inflow" persistable="0" isFixedValue="0" formula="QLrE2qKv4EKJk_U9-BXBmA" dim="Flow (volume)" quantityType="0" />
-                    <Parameter id="QTYfHi1POEWI4yAGgD92BQ" name="Thickness of gut wall" description="Thickness of Gut Wall" persistable="0" isFixedValue="0" formula="CrwFKdc0AkmmncutO67a1A" dim="Length" quantityType="0" />
-                    <Parameter id="iAYwPEcCN0CYRVpVUwaw3Q" name="Distal radius" description="Distal radius of intestinal segment" persistable="0" isFixedValue="0" formula="R46ArBLQ1US2Gb1bCChBmA" dim="Length" quantityType="0" />
-                    <Parameter id="CKpswEl0B0inidb61lJjkw" name="pH" description="pH" persistable="0" isFixedValue="0" formula="ZyVIkMhwd02m4zT5i32SnQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="EK-beIMM3kGFNg9pS1KnWA" name="Microvilli factor" description="Microvilli factor" persistable="0" isFixedValue="0" formula="gKChbtLwbUurWQ_a7VPKxw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="TuHwmNMpPkeTdRvQ-uLH-Q" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="_LLSskDJIUuVhrPf1IvLNA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="HDgmochzcEmOywvv6z8HCw" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="h9SLk-nHqkeqEKmtymXHCg" dim="Length" quantityType="0" />
-                    <Parameter id="4tBZ3csMhUSEX7d9slnAKA" name="Intestinal transit rate" description="Transit rate along intestinal segments" persistable="0" isFixedValue="0" formula="2nbBfaUMPkWWpDiGmtIWIg" dim="InversedTime" quantityType="0" />
-                    <Parameter id="D6EZgSID-UWljqvcGSBE7w" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" persistable="0" isFixedValue="0" formula="4rhW6oVHOUazss5S73sSMQ" dim="Fraction" quantityType="0" />
-                    <Parameter id="h4ToLDoZSUWeJWin1C09AQ" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="odgP-6Z7WEOs5wXoiJIEbw" dim="Length" quantityType="0" />
-                    <Parameter id="hiAO_Ww-8Uqf-LCtMVae3Q" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" formula="2xJD4jzcVkqNRD893R1Xog" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="ezYXLZUzSkClHNMvWgFwTg" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="TVlARGS1o0K8Bl9-Cg2efA" dim="Length" quantityType="0" />
-                    <Parameter id="BCsPg4j60E-6ZbCJm0vHZw" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="DN6q1tSDg0-Hv2GO4xyR5Q" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="rcZPMB6m-kq9F2bIVOsFQA" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" formula="gxOwpDwJJEC_3nnUOkVG_w" dim="InversedLength" quantityType="0" />
-                    <Parameter id="DsqfGzy9QEaEpR7J0cf3Kg" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" formula="lhiMhYvLn0iMFqQkuINlWA" dim="Length" quantityType="0" />
-                    <Parameter id="H0gT_6xi6EeBx-eb5GeFNg" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" formula="2Dgsog116k-3TPVwSg04uw" dim="Length" quantityType="0" />
-                    <Parameter id="n_pb-ss4MUK1jcFevIE-Lw" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="Wif4JJxOv0O4jP_eWr8uPA" dim="Dimensionless" quantityType="0" />
-                    <MoleculeAmount id="sGszVTR3d0Wpec6uwVrB5Q" name="Drug" icon="Drug" persistable="0" isFixedValue="0" formula="7HBSa0f2xE2XR0DLKmznpg" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="7jWhns7oEka2S5o-qN2fFQ" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Parameter id="Bxbnly101kSHF-EZgCNofg" name="Solubility" description="Solubility" persistable="0" isFixedValue="0" formula="6gsw_VV9bESvseWS6KkPhw" dim="Concentration" quantityType="0" />
-                        <Parameter id="0oBzHf3aI06zgv3CiC_QCA" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="hGInJ88jskm5gR5dgYqsdw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="ZJdUgKmzDkinunQpXNR7tA" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="kAIhNXE70E-uKWeB7fFf2g" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="NmJO9DECFkGxk3-bqvd6WQ" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="S8Drwx__mEiyjGyOGk3ZWw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="ip7U8zTxcEyJYhusqmkr8w" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="S6uzDg7lB0aqRJ_GV9sRRg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="GYaF5KNXTk6iRle-23qguw" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="wiJUnQrt10umU6nDHpqhEg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="7Y7YCqgZJ0ykHQZ2aO9fxg" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="ny31uD0_SkmO2lDYk-0scg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="H9Ov7OhynEe_D5E-mLaTtw" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="0Qfu5pIVi0qOtEbjbUz2KA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="xmmFqSZXk0aC3wQmZXgiGg" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="QISECmeXSE-S4FeikgVpMA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="NMSgI-jLDU-9VpPNTSpoPA" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="ryQl8WD7EU64gOTwEuCD8Q" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="CcOzlwhJUEucGkBDIvG20w" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="30kK4FEhL0qSxKvafGiduQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="dpc3LJWEwk-ohcZ2i3_98Q" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="JCI6jJpQPUa8m3lPzXfddQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="hiVghXmeKUKnNKXXmaQBxA" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" persistable="0" isFixedValue="0" formula="yQ5_hfDBo0We-R7CINBbYg" dim="Amount" quantityType="0" rHSFormula="QPG2cm-kr0Ks2PBO04jJ8Q" />
-                        <Parameter id="2UI_nhYgRki0t2GBsWxXdQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="qaYxHzesFU2WHoKj2h3EJw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="BF18xOvnuU-DN2YbnOecIA" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" persistable="0" isFixedValue="0" formula="n93jclfGmE-nKik3wuE0CA" dim="Dimensionless" quantityType="0" />
-                        <Observer id="LCGFZ4HjIk-78eJd6VH1Vw" name="Concentration in lumen" description="Concentration of the molecule in lumen" persistable="1" isFixedValue="0" formula="j43RhC6Wv0W0HJ9_uFMTPw" dim="MolarConcentration" quantityType="Drug, Observer" />
-                        <Observer id="P6MSED9Fv0eCX5KlzTCA2Q" name="Fraction of oral drug mass absorbed into mucosa segment" description="Fraction of oral drug mass absorbed into mucosa segment" persistable="1" isFixedValue="0" formula="5nbLuxyKsUig2MN-jcY9IA" dim="Fraction" quantityType="Drug, Observer" />
-                      </Children>
-                    </MoleculeAmount>
-                    <MoleculeAmount id="5BIOEi87FEOO9iFkXI7Ujw" name="Cyp" icon="Enzyme" persistable="0" isFixedValue="0" formula="wb5yCXJZxUeVY_7iSBmoSg" dim="Amount" quantityType="Enzyme" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="pj6P46N6lUCm9dB2VzWpvA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" formula="jWri_Cw1TUelu40Wzz4GNg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="GL-qLQLq4kufbx9g-uFH0w" name="Relative expression out." description="Relative Expression that will be used in the simulation" persistable="0" isFixedValue="0" formula="GtBZCb_uvUKgURPKDkyZKA" dim="Fraction" quantityType="0" />
-                        <Parameter id="gzXRSHstgk2mWWKf4Myglw" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" persistable="0" isFixedValue="0" formula="8F7Xbf9SrkCdegSeMeo6xA" dim="Fraction" quantityType="0" />
-                        <Parameter id="MrjCPJED5Em5pg82ZXZ46w" name="Relative expression" description="Relative expression" persistable="0" isFixedValue="0" formula="EsHeQ6mxJEeLuzWJRpqjug" dim="Fraction" quantityType="0" />
-                        <Parameter id="wwcj9GMljECv3njYF7mAXA" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                      </Children>
-                    </MoleculeAmount>
-                    <MoleculeAmount id="kw9OnoSiSUSabEtaZE2MqQ" name="Drug-Cyp Metabolite" persistable="0" isFixedValue="0" formula="nhiKtl0eP0CBi1GWT5g7sg" dim="Amount" quantityType="Metabolite" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="IT0cUSJba0qoylFp4EamwQ" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Observer id="wGwn8HXMHEKgOvo2AK7Xvw" name="Fraction of dose" description="Metabolized fraction of administered dose" persistable="1" isFixedValue="0" formula="aUoTQ3n3a0OShljd8bUj3w" dim="Fraction" quantityType="Metabolite, Observer" />
-                      </Children>
-                    </MoleculeAmount>
-                    <Reaction id="tgEBpXmqCE68NqRQl6oLtQ" name="Cyp-ME" icon="Metabolism" mode="Logical" containerType="Other" dimension="Dimensionless" formula="NrKgrsKmwkiGET1q7OIPYg">
-                      <Educts>
-                        <ReactionPartner stoichiometricCoefficient="1" partner="sGszVTR3d0Wpec6uwVrB5Q" />
-                      </Educts>
-                      <Products>
-                        <ReactionPartner stoichiometricCoefficient="1" partner="kw9OnoSiSUSabEtaZE2MqQ" />
-                      </Products>
-                      <ModifierNames>
-                        <ModifierNamesChild>Cyp</ModifierNamesChild>
-                      </ModifierNames>
-                    </Reaction>
-                  </Children>
-                </Container>
-                <Container id="zkRRnNgDBEmC3Btt-NZx3g" name="UpperIleum" description="Upper Ileum" icon="UpperIleum" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="UpperIleum" />
-                    <Tag value="Lumen" />
-                    <Tag value="LumenSegment" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="HyRzTknoNECOSbfnYtekRQ" name="Absorption of liquid" description="rate of liquid outflow" persistable="0" isFixedValue="0" formula="zepsMdcPyEORZ5zSsPaEYw" dim="InversedTime" quantityType="0" />
-                    <Parameter id="Tpm0T4UjZ0mqmaj2c-TCcQ" name="Distal radius" description="Distal radius of intestinal segment" persistable="0" isFixedValue="0" formula="R46ArBLQ1US2Gb1bCChBmA" dim="Length" quantityType="0" />
-                    <Parameter id="CdM_AJ5QTEaROPhjp-35cA" name="FillLevelFlag" description="Fill Level Flag" persistable="0" isFixedValue="0" formula="pBby0d8e50ijLxI1Zd-y8A" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="wLi9SRGqqEeP592S68FJlA" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" persistable="0" isFixedValue="0" formula="SdN69bnvNEKeuk8z2n3lGQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="wWWA_XbkUEu8ekJzsWwxyA" name="Geometric surface area" description="Geometric surface area of GI segment" persistable="0" isFixedValue="0" formula="ngGNoTJOo0KP78BsUQle0g" dim="Surface" quantityType="0" />
-                    <Parameter id="1LbsiA-e6E-mX3FpXpG2lg" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" persistable="0" isFixedValue="0" formula="KHYs_0LiaU-rFY5q8jpGaA" dim="InversedTime" quantityType="0" />
-                    <Parameter id="NWXb4kr4D0mWCyFd0uI1zg" name="Length" description="Length" persistable="0" isFixedValue="0" formula="GC0lSgOyJUOIXmPp5q-wcg" dim="Length" quantityType="0" />
-                    <Parameter id="NX1kOUUmbk28yYJkbAqY9g" name="Liquid" description="Liquid" persistable="0" isFixedValue="0" formula="R6kHqMVgX0GtvICqeL6FFw" dim="Volume" quantityType="0" rHSFormula="zG7ehoVeNU2Tt7ng3dZN4g" />
-                    <Parameter id="22TjKEwTlEqTNsXBdmhfAQ" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" persistable="0" isFixedValue="0" formula="AJGACv7K9kWT4hoF7cCeNA" dim="Rate" quantityType="0" />
-                    <Parameter id="rtC5uWb75EesX4C3nX8pPw" name="Proximal radius" description="Proximal radius of intestinal segment" persistable="0" isFixedValue="0" formula="bOSpmtTi7k2o4j709TGn3A" dim="Length" quantityType="0" />
-                    <Parameter id="yBfyxiIsYkqa6udtZ57AwQ" name="Thickness of gut wall" description="Thickness of Gut Wall" persistable="0" isFixedValue="0" formula="CrwFKdc0AkmmncutO67a1A" dim="Length" quantityType="0" />
-                    <Parameter id="13Jh_DNfa0S2UYj5AgLJ4Q" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="xhED215POEuWycLJEijJ4Q" dim="Volume" quantityType="0" />
-                    <Parameter id="qKwbV8V9LUKMEcG-zMzHPg" name="Volume (gut wall)" description="Volume of the gut wall" persistable="0" isFixedValue="0" formula="1JjHOu_qXUCfLrDZjfqvTA" dim="Volume" quantityType="0" />
-                    <Parameter id="cCx919zJYUKP1k0xp3C57Q" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="owgI66XQcE2ClB4BHV50ew" dim="Volume" quantityType="0" />
-                    <Parameter id="eah0yqRZSkm70um3J4DU3w" name="Secretion of liquid" description="Rate of liquid inflow" persistable="0" isFixedValue="0" formula="CNlqTSBIzUqNYlonSZz13w" dim="Flow (volume)" quantityType="0" />
-                    <Parameter id="GnTyFBljNEm5886oDNVyRg" name="pH" description="pH" persistable="0" isFixedValue="0" formula="IkoD6u7LskaeJhn6byyisQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="nM9Ov_ErTEKRVr8xr5J_oA" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" formula="Xr8NMtZiuUCi9sY4xDHOKg" dim="InversedLength" quantityType="0" />
-                    <Parameter id="MvYoUhiXhk27ug917odx0g" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="4oWmhRVibkGfNZNnUxQJuQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="WqnH6ZQfKkSptWOFuW67lA" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" formula="neq327vae0i0RmJkz3uLtA" dim="Length" quantityType="0" />
-                    <Parameter id="UoiMkhiE3EKTBEXnQhG_aw" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" persistable="0" isFixedValue="0" formula="-uyyUPh1CEOK5xKCHCLkpA" dim="Fraction" quantityType="0" />
-                    <Parameter id="bfrHJo8ujESuopwz5rJzxA" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="u7qiKo8iM0erjGnwrWPbMg" dim="Length" quantityType="0" />
-                    <Parameter id="yvrGLNXJdUmplqjNwegt8Q" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="-v356U7_bkCPH470J6q8iQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="icJHdji3LEShXoXmRYZ3Fw" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="fPRwwELTDUWj3BZa3bFZvg" dim="Length" quantityType="0" />
-                    <Parameter id="glrmP9cdEESFoVO4BUCgMw" name="Microvilli factor" description="Microvilli factor" persistable="0" isFixedValue="0" formula="sxTw1j6NzkKPtwvMruKM6w" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="A7Qq7Ot_QU6txOT4nj-EnQ" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="bWTJF8UEV0S0oIpIvfdjww" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="UbSMjFNxyEi4kyEN6tenYg" name="Intestinal transit rate" description="Transit rate along intestinal segments" persistable="0" isFixedValue="0" formula="CQJrcPYWf06s4dKp19jlcA" dim="InversedTime" quantityType="0" />
-                    <Parameter id="MvFrYw211UqR0DbzVEHeHA" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" formula="fMYxucXf-0W3akAh1xGKZA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="yIg0Ju7crk-FMWDHm41AAw" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" formula="2ZLmVqhLsEevMcbpZ7QTkg" dim="Length" quantityType="0" />
-                    <Parameter id="7xQL7jepR0iZosZ9L3HRJw" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="4sayDkot7U6I2_VtNq8yDg" dim="Length" quantityType="0" />
-                    <MoleculeAmount id="zyfJQqKwG0qIQhif8G_fgg" name="Drug" icon="Drug" persistable="0" isFixedValue="0" formula="YUUkRozlSEaz2dPSdY6B1Q" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="ss6y_piz0ky5lLt8WG0SCg" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Parameter id="RSCdVhz9ekOSIM-5GR2cKA" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CtYyJO3ULU-odzn7WFdimA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="efMwre6V70-ilVz5TZX9-A" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" persistable="0" isFixedValue="0" formula="eEWiszy-H0GZ0r_jBXic1A" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="m4HAMIITlkugQj6R8ABPVA" name="Solubility" description="Solubility" persistable="0" isFixedValue="0" formula="fwPjHhNRhkqUA60riuNtQA" dim="Concentration" quantityType="0" />
-                        <Parameter id="C3l2EpH8ekO_HHvPRBYnlA" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="y0JgC19SOUaYBnT2HFADkQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="1AtRFqgDqE2WR7Dtqa0Wqg" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="hrsFs9lKNESLaXOXmVkj5g" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="8QGERBxjIkCIS2ZlbpahSg" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" persistable="0" isFixedValue="0" formula="E4jyhZeM8E-o1WaIanf7ig" dim="Amount" quantityType="0" rHSFormula="1LHPopet_0SxLA3vQltolQ" />
-                        <Parameter id="_ICs9ysyh0SUl9WSazfiGQ" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="XpvI7-gVXkitvnt98pmm5w" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="PIwmt41a_kSe_yuWdUQKsg" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="lYsx1jBa50O4POUDVjCg1Q" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="xf5WjoRaukSVqvswlWQDdQ" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="-cnDt52ID06FkiLqTcOi9Q" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="_Do9tAbUeUeXmmc2u46Ceg" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="SPPaf8LHo02OGbdjxcNQ1Q" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="dsZNbavIfUW4SlNCjU4uoA" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="cbWC6sGkz0OpviSxnQn0lQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="hXPi_B9JwU-rkJ5zRPsQOQ" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="Fzn73RkPrkug9gAfPyhnGw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="KwlLies8p0iebkRcBB2B7g" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="C6zUhtxvukmjHH9Pjk9fOg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="bzdk4Cic1E-RV1oJkZ8NPg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="G8USEqb_G0mbDcNivtc2Pg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="QuTebWNyg0KzZpkhVfNCvA" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="lJdJMouy-kq4d_gve1ZZCw" dim="Dimensionless" quantityType="0" />
-                        <Observer id="cDNyVlvi50mxm_o3pTHokw" name="Concentration in lumen" description="Concentration of the molecule in lumen" persistable="1" isFixedValue="0" formula="j43RhC6Wv0W0HJ9_uFMTPw" dim="MolarConcentration" quantityType="Drug, Observer" />
-                        <Observer id="bkMyIT5GCEONr35db5Bh1w" name="Fraction of oral drug mass absorbed into mucosa segment" description="Fraction of oral drug mass absorbed into mucosa segment" persistable="1" isFixedValue="0" formula="5nbLuxyKsUig2MN-jcY9IA" dim="Fraction" quantityType="Drug, Observer" />
-                      </Children>
-                    </MoleculeAmount>
-                    <MoleculeAmount id="sunEgxFPGkeQgDo1grK-DA" name="Cyp" icon="Enzyme" persistable="0" isFixedValue="0" formula="wb5yCXJZxUeVY_7iSBmoSg" dim="Amount" quantityType="Enzyme" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="4nHCwW65ZEuCgpoCa7eLzA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" formula="jqsopHsmqUeVyRuT3_x7xg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="4-EbqVc0yU2HBOVITQS01A" name="Relative expression out." description="Relative Expression that will be used in the simulation" persistable="0" isFixedValue="0" formula="GtBZCb_uvUKgURPKDkyZKA" dim="Fraction" quantityType="0" />
-                        <Parameter id="XHnAyU55J0ija1YTCesKMA" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" persistable="0" isFixedValue="0" formula="KFVBgTU6Dk28zPhm4CGgBw" dim="Fraction" quantityType="0" />
-                        <Parameter id="yDdkvsUsx06QoJ2dEeadbQ" name="Relative expression" description="Relative expression" persistable="0" isFixedValue="0" formula="7bFUOXMvvkSdcZ1KrbILdw" dim="Fraction" quantityType="0" />
-                        <Parameter id="EZ97X29EjEmcmxm08yKPrw" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                      </Children>
-                    </MoleculeAmount>
-                    <MoleculeAmount id="i8YHb3D9b0SzYGOXPIG4oA" name="Drug-Cyp Metabolite" persistable="0" isFixedValue="0" formula="3J9ZeOK5IkG6Y24OreOA3g" dim="Amount" quantityType="Metabolite" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="VAi4UR4bE0inSAKqBnfI8Q" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Observer id="1U6gOJPbwUC0a4o87_y5vA" name="Fraction of dose" description="Metabolized fraction of administered dose" persistable="1" isFixedValue="0" formula="aUoTQ3n3a0OShljd8bUj3w" dim="Fraction" quantityType="Metabolite, Observer" />
-                      </Children>
-                    </MoleculeAmount>
-                    <Reaction id="KDwI_GNtRE6Mq58qHMuveg" name="Cyp-ME" icon="Metabolism" mode="Logical" containerType="Other" dimension="Dimensionless" formula="NrKgrsKmwkiGET1q7OIPYg">
-                      <Educts>
-                        <ReactionPartner stoichiometricCoefficient="1" partner="zyfJQqKwG0qIQhif8G_fgg" />
-                      </Educts>
-                      <Products>
-                        <ReactionPartner stoichiometricCoefficient="1" partner="i8YHb3D9b0SzYGOXPIG4oA" />
-                      </Products>
-                      <ModifierNames>
-                        <ModifierNamesChild>Cyp</ModifierNamesChild>
-                      </ModifierNames>
-                    </Reaction>
-                  </Children>
-                </Container>
-                <Container id="Lk6M-N8TdEOKfd5gHwDSMQ" name="LowerIleum" description="Lower Ileum" icon="LowerIleum" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="LowerIleum" />
-                    <Tag value="Lumen" />
-                    <Tag value="LumenSegment" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="6L_W_aWupUSg8iFG0adgOA" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" persistable="0" isFixedValue="0" formula="0Qtj8P1IfU-lLI_1WC6T0g" dim="Rate" quantityType="0" />
-                    <Parameter id="OEfxsBf6bU6oplGclJY6cQ" name="Proximal radius" description="Proximal radius of intestinal segment" persistable="0" isFixedValue="0" formula="bOSpmtTi7k2o4j709TGn3A" dim="Length" quantityType="0" />
-                    <Parameter id="xWy-mSRv10Kyr3JTU6Ne8w" name="Secretion of liquid" description="Rate of liquid inflow" persistable="0" isFixedValue="0" formula="sbNsbUh-J0-vwJl2ZhfrSg" dim="Flow (volume)" quantityType="0" />
-                    <Parameter id="dTGrCblLgUis1fFTOrNLNw" name="Thickness of gut wall" description="Thickness of Gut Wall" persistable="0" isFixedValue="0" formula="CrwFKdc0AkmmncutO67a1A" dim="Length" quantityType="0" />
-                    <Parameter id="WitANq3xSEG28JhPfREqvg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="xhED215POEuWycLJEijJ4Q" dim="Volume" quantityType="0" />
-                    <Parameter id="eDnExP7eQki76P_HhYNv4A" name="Volume (gut wall)" description="Volume of the gut wall" persistable="0" isFixedValue="0" formula="1JjHOu_qXUCfLrDZjfqvTA" dim="Volume" quantityType="0" />
-                    <Parameter id="riu7r1MQSU6bel02oeQPoQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="owgI66XQcE2ClB4BHV50ew" dim="Volume" quantityType="0" />
-                    <Parameter id="fowv-X94H0GWd3VK4-zyuA" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" persistable="0" isFixedValue="0" formula="QVDtQgXOkEarj7mKbTy5FQ" dim="InversedTime" quantityType="0" />
-                    <Parameter id="J7isUVx-wEOe6aLmwM50Ag" name="Liquid" description="Liquid" persistable="0" isFixedValue="0" formula="R6kHqMVgX0GtvICqeL6FFw" dim="Volume" quantityType="0" rHSFormula="UDMy90dUIUOZkFU8dmXwOQ" />
-                    <Parameter id="6gubD238HkO0g-eqHi3i-Q" name="Absorption of liquid" description="rate of liquid outflow" persistable="0" isFixedValue="0" formula="gjiUgYMHgE6Nac05kg5fBQ" dim="InversedTime" quantityType="0" />
-                    <Parameter id="nN-TdvXu20WG-PmVwvz1Dg" name="Distal radius" description="Distal radius of intestinal segment" persistable="0" isFixedValue="0" formula="R46ArBLQ1US2Gb1bCChBmA" dim="Length" quantityType="0" />
-                    <Parameter id="TcXqdMviaE-zS52A2VLqdg" name="FillLevelFlag" description="Fill Level Flag" persistable="0" isFixedValue="0" formula="pBby0d8e50ijLxI1Zd-y8A" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="4DNwxQet1Ee72kk59yusbA" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" persistable="0" isFixedValue="0" formula="SdN69bnvNEKeuk8z2n3lGQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="NaOSoRbOWUCNQ8v2u-dAYQ" name="Geometric surface area" description="Geometric surface area of GI segment" persistable="0" isFixedValue="0" formula="ngGNoTJOo0KP78BsUQle0g" dim="Surface" quantityType="0" />
-                    <Parameter id="biybYBHmJUy5JntH7fDntQ" name="Length" description="Length" persistable="0" isFixedValue="0" formula="GC0lSgOyJUOIXmPp5q-wcg" dim="Length" quantityType="0" />
-                    <Parameter id="pm7lvykhk0GHN5I227G14w" name="Microvilli factor" description="Microvilli factor" persistable="0" isFixedValue="0" formula="GBsse-2rIE6VU45Y_DsMvw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="_XjRS0bqs02dKq2nvssQHQ" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" formula="LJd_X5fmh0C0iXhkFWW63g" dim="Length" quantityType="0" />
-                    <Parameter id="HNCxzTBBRU6WC7PHRwuOMw" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="dEqADjHncUOjFxq-m8EIwg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="PfYPjqUq_0GLdyL7ShFQWg" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="z1EfWOA2YUOZ4fjs3OIhpQ" dim="Length" quantityType="0" />
-                    <Parameter id="4ktG3B3wLk-w-yS3DHh66g" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="cNArocr-Mkyklx4zxgwGnA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="rPpwo-nqXUOWyg_db7CpMg" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" formula="dwRhMy0IVUiSzLAGfBSpog" dim="InversedLength" quantityType="0" />
-                    <Parameter id="4oxL8tONiEGF9gSzGBjhKw" name="pH" description="pH" persistable="0" isFixedValue="0" formula="2_ItvqAuO06G7_4rE0668A" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="83yd_SoxrUS302nFjeLzvQ" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="kOqQ-hv0KES8zgbmSjfn6Q" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="jAwX60tZJkS7PjUXKwdxIg" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="VvbX4yaPt0CxTRLyJ-UySw" dim="Length" quantityType="0" />
-                    <Parameter id="4yUnLbvQQUqs--FNOr3NTA" name="Intestinal transit rate" description="Transit rate along intestinal segments" persistable="0" isFixedValue="0" formula="2H2QRUP_RkmQaQxnF9vBNQ" dim="InversedTime" quantityType="0" />
-                    <Parameter id="sFXQ11knakeyJnwHtJ8bfA" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" persistable="0" isFixedValue="0" formula="zFoEtMD_1Ue1T8dMhauV3A" dim="Fraction" quantityType="0" />
-                    <Parameter id="kVGxgYIJBES2WlQY6hJ6Fw" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" formula="_rDBzfVntUWJfzCAiwGv4g" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="lvRiF2Tknky_x-gFc-TblQ" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="zQOuAimoOE6M1wOS-VzTfA" dim="Length" quantityType="0" />
-                    <Parameter id="laOsaw15z0Kb8TVRBuX8Tw" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" formula="dh6VEOsTwk-fF2AOvpSPbA" dim="Length" quantityType="0" />
-                    <MoleculeAmount id="2rK9g1SMCEOsiulUb04Htg" name="Drug" icon="Drug" persistable="0" isFixedValue="0" formula="WVDDXme5HU-bave5pzGcmA" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="mDZuSGDoNUKcwbIM5TGAAA" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Parameter id="Fju60yIaqEmRGtDfwHQH5w" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" persistable="0" isFixedValue="0" formula="gjtSv0nhQ0SKPsKNYoeW7w" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="RHNFm9LR9EmAWnxkGkgEBQ" name="Solubility" description="Solubility" persistable="0" isFixedValue="0" formula="b5YOJ65-r0a2fIZ6nmANwQ" dim="Concentration" quantityType="0" />
-                        <Parameter id="hUvEYwG5k0GBopIW8NvdzQ" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="avCH91vwAk64bsy5UxTMOQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="FNRoL9kpskOpYF5tdpsZTA" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="6zMPa-EDgkO3GcYfKHwhmw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="qDOcudhKSUG4t0AbwDiS4w" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="5HzGw4w-DEWUAwCLDDQf7A" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="Yn5XsCUhmkSj-Sg0eUzDGQ" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="tTlyqJ90akupI36RJgIYfQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="s2dS3NO8U0-7PZHq-ppQFA" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="FwsBZex0yUC7ydmB-AQ2qA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="l_pROou_8EaV4g1YA1ubfA" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="BYT5eQ8Z2EmPhLZPBTU2eA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="5Lg_LO6Xj0-JRkSzkWJNsg" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="Yr6VT5ivok6r7K8NmV5ngQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="ha7Wv5TwX0ClrP8i7rq9cA" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="6F580dELsk68JQsHS7tnPA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="MFKEOZ5ogUWla-FPoiwtwQ" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="2Ky3Y3gnPkuzL1q4lauJbA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="X5n3NQfUf0Keim1-di7u0g" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="fVvN4E9gs02GrCkQiSP0HA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="dpsFdD09AE6O0kd2XSlNaw" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="V_jGKFDxNkKqoSUZ42lCCQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="f9etrEr5IkmoWGbYkyy-Jg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="1x5wuGQ4QEuwy7xmPFNp1A" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="CpC6grSqxk2ImJINcRyxzQ" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" persistable="0" isFixedValue="0" formula="MKbyQUVRdUGzOb6dPiMVag" dim="Amount" quantityType="0" rHSFormula="uWUBaQ-SCEao9LOzG5lWpg" />
-                        <Observer id="s96DRl_z-0eOplHZLYAdDw" name="Concentration in lumen" description="Concentration of the molecule in lumen" persistable="1" isFixedValue="0" formula="j43RhC6Wv0W0HJ9_uFMTPw" dim="MolarConcentration" quantityType="Drug, Observer" />
-                        <Observer id="ggCK3-9LU0iOR7OTdUnyyQ" name="Fraction of oral drug mass absorbed into mucosa segment" description="Fraction of oral drug mass absorbed into mucosa segment" persistable="1" isFixedValue="0" formula="5nbLuxyKsUig2MN-jcY9IA" dim="Fraction" quantityType="Drug, Observer" />
-                      </Children>
-                    </MoleculeAmount>
-                    <MoleculeAmount id="h_ipezhnd0ajXapl5ywmiw" name="Cyp" icon="Enzyme" persistable="0" isFixedValue="0" formula="wb5yCXJZxUeVY_7iSBmoSg" dim="Amount" quantityType="Enzyme" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="4yWjWnqhRUSuPwZYKdIOXA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" formula="SCwpHKYeokWqUttjC6EWaA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="cI4HvsNUlk6_96ifR7Z17Q" name="Relative expression out." description="Relative Expression that will be used in the simulation" persistable="0" isFixedValue="0" formula="GtBZCb_uvUKgURPKDkyZKA" dim="Fraction" quantityType="0" />
-                        <Parameter id="3pcGSaNeakqnF6J095llrA" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" persistable="0" isFixedValue="0" formula="CWdJeS_STkSWBK2MYrxnag" dim="Fraction" quantityType="0" />
-                        <Parameter id="qYG_sV4r-0mYr1w3NpWPGg" name="Relative expression" description="Relative expression" persistable="0" isFixedValue="0" formula="6tYwugLelkWbj3CFCEbpmg" dim="Fraction" quantityType="0" />
-                        <Parameter id="1wV-G_tD_0yr3DPN1prLLg" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                      </Children>
-                    </MoleculeAmount>
-                    <MoleculeAmount id="l1YoyLuokkeyG9ptAEs7nw" name="Drug-Cyp Metabolite" persistable="0" isFixedValue="0" formula="yAP45TjCfUeKcXSZdL-mbA" dim="Amount" quantityType="Metabolite" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="yOzcLZTx9EqeLiettNi2dA" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Observer id="nRb3UUqwz0a-WGKEsLJx0w" name="Fraction of dose" description="Metabolized fraction of administered dose" persistable="1" isFixedValue="0" formula="aUoTQ3n3a0OShljd8bUj3w" dim="Fraction" quantityType="Metabolite, Observer" />
-                      </Children>
-                    </MoleculeAmount>
-                    <Reaction id="89ejlTHo20eOGKiJFb1YvA" name="Cyp-ME" icon="Metabolism" mode="Logical" containerType="Other" dimension="Dimensionless" formula="NrKgrsKmwkiGET1q7OIPYg">
-                      <Educts>
-                        <ReactionPartner stoichiometricCoefficient="1" partner="2rK9g1SMCEOsiulUb04Htg" />
-                      </Educts>
-                      <Products>
-                        <ReactionPartner stoichiometricCoefficient="1" partner="l1YoyLuokkeyG9ptAEs7nw" />
-                      </Products>
-                      <ModifierNames>
-                        <ModifierNamesChild>Cyp</ModifierNamesChild>
-                      </ModifierNames>
-                    </Reaction>
-                  </Children>
-                </Container>
-                <Container id="hnrXLSFg2E-aaJshK4BODA" name="Caecum" description="Cecum" icon="Caecum" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Caecum" />
-                    <Tag value="Lumen" />
-                    <Tag value="LumenSegment" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="r5jaUZh4eke5bT7EA3C-Vg" name="Volume (gut wall)" description="Volume of the gut wall" persistable="0" isFixedValue="0" formula="1JjHOu_qXUCfLrDZjfqvTA" dim="Volume" quantityType="0" />
-                    <Parameter id="HAc7xWbGQEiL5Qft3EJK-A" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="xhED215POEuWycLJEijJ4Q" dim="Volume" quantityType="0" />
-                    <Parameter id="2_MWZuPyhECW8ZPQACaA5Q" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" persistable="0" isFixedValue="0" formula="SdN69bnvNEKeuk8z2n3lGQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="qTcGKiSoBEOQuY0I0Ctciw" name="Absorption of liquid" description="rate of liquid outflow" persistable="0" isFixedValue="0" formula="67cI_wremUeT0R2mvThImw" dim="InversedTime" quantityType="0" />
-                    <Parameter id="KlrdIPetmESuOJ4xb4uxEA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="owgI66XQcE2ClB4BHV50ew" dim="Volume" quantityType="0" />
-                    <Parameter id="8GA9HsP8w0e3dPvIs1WyHQ" name="FillLevelFlag" description="Fill Level Flag" persistable="0" isFixedValue="0" formula="pBby0d8e50ijLxI1Zd-y8A" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="wfgs2sUgR0u5moNDYb5NYQ" name="Geometric surface area" description="Geometric surface area of GI segment" persistable="0" isFixedValue="0" formula="ngGNoTJOo0KP78BsUQle0g" dim="Surface" quantityType="0" />
-                    <Parameter id="ckCvG3qrvEycJKoAHSECDw" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" persistable="0" isFixedValue="0" formula="96qOe-_FYUSWaqpEL62Siw" dim="InversedTime" quantityType="0" />
-                    <Parameter id="vAcPO_Fd2E-PZhHi7hx7Ag" name="Length" description="Length" persistable="0" isFixedValue="0" formula="GC0lSgOyJUOIXmPp5q-wcg" dim="Length" quantityType="0" />
-                    <Parameter id="dRFDMUF9PU2n6N0SMLcIcQ" name="Liquid" description="Liquid" persistable="0" isFixedValue="0" formula="R6kHqMVgX0GtvICqeL6FFw" dim="Volume" quantityType="0" rHSFormula="Z1FqKiLWrkSre006MGntbg" />
-                    <Parameter id="xNfa_G-8vkiHv3wyoYRRPw" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" persistable="0" isFixedValue="0" formula="8zK7g_8kW0a9S5pM5_WnaQ" dim="Rate" quantityType="0" />
-                    <Parameter id="VCg3Iqk1L02aa5LwVgezcA" name="Proximal radius" description="Proximal radius of intestinal segment" persistable="0" isFixedValue="0" formula="bOSpmtTi7k2o4j709TGn3A" dim="Length" quantityType="0" />
-                    <Parameter id="rzS8w90vjU2ZezsHQkUv1g" name="Secretion of liquid" description="Rate of liquid inflow" persistable="0" isFixedValue="0" formula="ZP6U8bDDcUKkjp1G1qYp3g" dim="Flow (volume)" quantityType="0" />
-                    <Parameter id="cGRoNGcEm0iIFx-HiO11IQ" name="Thickness of gut wall" description="Thickness of Gut Wall" persistable="0" isFixedValue="0" formula="CrwFKdc0AkmmncutO67a1A" dim="Length" quantityType="0" />
-                    <Parameter id="6pOvfqNaAECifeJJD8YQ4A" name="Distal radius" description="Distal radius of intestinal segment" persistable="0" isFixedValue="0" formula="R46ArBLQ1US2Gb1bCChBmA" dim="Length" quantityType="0" />
-                    <Parameter id="wBa0oL4iK0OuzFmyO0bgxw" name="pH" description="pH" persistable="0" isFixedValue="0" formula="kwEnf1eu3UO1B0i7yi6svA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="qKQLSbRRSUiAVF1G_4zuXA" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" formula="ajoruUSFl0G9CzZt4I1L7w" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="qGeHcJ9aVUCfSswHGKggmQ" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="N0wZFvZ10UG3hLl81MfWKQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="u8pm44JiR0OFCDetstI2Nw" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" formula="8uGoyxSxhkG8kwzaJp3bDw" dim="InversedLength" quantityType="0" />
-                    <Parameter id="vCUvdpIBdEG3EbpNm-z2Ag" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" formula="Jwl3OxAXpU2_ft1TkYd6Hw" dim="Length" quantityType="0" />
-                    <Parameter id="OhndVfeNAEODc4FeggluaA" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" formula="-WqpQgHGQEmGH1S7_XT-Ww" dim="Length" quantityType="0" />
-                    <Parameter id="CDDdbnvKtEWxxxB1A-q8ew" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="tcZb0maaUU6N1GFhiLjsbA" dim="Length" quantityType="0" />
-                    <Parameter id="HLHo4hl10kWCETgqkxf5Zg" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="7Tw-02TusE2KYIaF5q7R3A" dim="Length" quantityType="0" />
-                    <Parameter id="DdI5htp41UqiYKnRaF7NLQ" name="Microvilli factor" description="Microvilli factor" persistable="0" isFixedValue="0" formula="TbP1yCgVFU6Udj5OUJ5b7g" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="z9WSLOzuM0CyTObKQVJcIQ" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="OvXNF2TUAUu7BfjjiN_31A" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="UYpOAlzW80-W7aCRkpi--A" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="gmzcnvpFekizKOfR8gSCUQ" dim="Length" quantityType="0" />
-                    <Parameter id="IZkU2O__9EGrN18ZVd1OUg" name="Intestinal transit rate" description="Transit rate along intestinal segments" persistable="0" isFixedValue="0" formula="SG2605b9-kODU86xRmCusg" dim="InversedTime" quantityType="0" />
-                    <Parameter id="15KXqO3FvUq4aQCW6DGAGg" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" persistable="0" isFixedValue="0" formula="advGi1hAq0y3rAFkYsZ0Pw" dim="Fraction" quantityType="0" />
-                    <Parameter id="AfpRiuMJSUypZLhuvuBrkg" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="FIKEA9Wdq0-_sk51h0HeZQ" dim="Dimensionless" quantityType="0" />
-                    <MoleculeAmount id="MnNILc-ThEuWb2MmUdz8QQ" name="Drug" icon="Drug" persistable="0" isFixedValue="0" formula="YOqIhwCaTkmpuLrBOPELvA" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="AQ_Lq19LjkuxE2PtWFRs5Q" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Parameter id="UtRdKYcxIUOwRRLyKqzv-w" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="XiaTZ2zgKEa2soF1Cd4Izw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="eAtDg6ZZYUGTzEhotX7Fng" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" persistable="0" isFixedValue="0" formula="ArT1ZX5SX0-og0CtPX2uGg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="7M2KpVpmWU-Ayor2RNkwyQ" name="Solubility" description="Solubility" persistable="0" isFixedValue="0" formula="Rc_aBl67GE29bFewOCL4wg" dim="Concentration" quantityType="0" />
-                        <Parameter id="mupmHR8v-UaFaPSXDB9OWg" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="N_Mnvkcuhkit18pbUSDxvw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="HPoCZfOf6UeG8a3RXSq-IQ" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="uqu2QvItwk2YLt6nWntrPA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="4v0B5aDcTEKcOovx6e6sXQ" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="J5SRraM5Okqeh3RpzEKd9g" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="ZpCoRMVuoUOrxrY_x0D5Kg" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="k-uqZI39xk2zuVbB1PykZA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="XMXtTaO_OkuMe50IsuSgdw" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="2GeEyPd_dky8llEbMBN3hA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="YkdddHBwskmK8tzugCrmsA" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="qoKG8I616E-OlQ4C7gIwfA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="sOfYlK3XrEatQIxwyI-ugA" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="Tp9ia2KReE2kcOG1klrnzQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="38UYmJa1tkeqmyLDK6msfA" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="JJ-zHhAjaU-AZfo495ugiQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="EQ2e1iOpFUaR3n2PrDgQ5A" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="j0KSpwvHREKph0gtyJUxKg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="oOcgv534B0SUSUFJJh4lag" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="QLuKcyCb5kOdupWTLhrTFg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="LnBIGddjsUCgo2GQI0drIg" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" persistable="0" isFixedValue="0" formula="suQZxujDrkC5FxBJiquzJA" dim="Amount" quantityType="0" rHSFormula="2636aZuGy02jKPoR3OROBA" />
-                        <Parameter id="CIoPS5qYokS0c930QhudJA" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="zzKb3G4__0SlVE7tgdMZgA" dim="Dimensionless" quantityType="0" />
-                        <Observer id="fxd-UuMeykOGEq9y6R1mug" name="Concentration in lumen" description="Concentration of the molecule in lumen" persistable="1" isFixedValue="0" formula="j43RhC6Wv0W0HJ9_uFMTPw" dim="MolarConcentration" quantityType="Drug, Observer" />
-                        <Observer id="iT6k9JJxDkWOFHoYacNbHQ" name="Fraction of oral drug mass absorbed into mucosa segment" description="Fraction of oral drug mass absorbed into mucosa segment" persistable="1" isFixedValue="0" formula="5nbLuxyKsUig2MN-jcY9IA" dim="Fraction" quantityType="Drug, Observer" />
-                      </Children>
-                    </MoleculeAmount>
-                    <MoleculeAmount id="XtXQ8DDRVkSS8PrWx82Z2Q" name="Cyp" icon="Enzyme" persistable="0" isFixedValue="0" formula="wb5yCXJZxUeVY_7iSBmoSg" dim="Amount" quantityType="Enzyme" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="aGo4QSJus0Kk-dvSHS3ArQ" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" formula="QgpVhCQJ-0ee2r6OEWx5XA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="OiK-b8vdFkmU8_1VEHSZLQ" name="Relative expression out." description="Relative Expression that will be used in the simulation" persistable="0" isFixedValue="0" formula="GtBZCb_uvUKgURPKDkyZKA" dim="Fraction" quantityType="0" />
-                        <Parameter id="wDSB3KvdE0OCYJIx_yJgEg" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" persistable="0" isFixedValue="0" formula="1zZl_8I89UCvw-cfIUCr-Q" dim="Fraction" quantityType="0" />
-                        <Parameter id="E5XxYnzSG0GgaDPhjp9Fnw" name="Relative expression" description="Relative expression" persistable="0" isFixedValue="0" formula="pL5JNqdhdEOjubsbirWy2A" dim="Fraction" quantityType="0" />
-                        <Parameter id="a6iraa1q-kWlCHjaewjWKA" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                      </Children>
-                    </MoleculeAmount>
-                    <MoleculeAmount id="hlgv7zvAHkKE5uX9r2PHaA" name="Drug-Cyp Metabolite" persistable="0" isFixedValue="0" formula="5gYQB-Rx5Uaq_2JREUmG1g" dim="Amount" quantityType="Metabolite" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="GHrx74yl0kmzCDzTslLvWA" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Observer id="34TYMz01pkumOpFKfozi_A" name="Fraction of dose" description="Metabolized fraction of administered dose" persistable="1" isFixedValue="0" formula="aUoTQ3n3a0OShljd8bUj3w" dim="Fraction" quantityType="Metabolite, Observer" />
-                      </Children>
-                    </MoleculeAmount>
-                    <Reaction id="iqQSCxgh7US-XAeT-BMkBA" name="Cyp-ME" icon="Metabolism" mode="Logical" containerType="Other" dimension="Dimensionless" formula="NrKgrsKmwkiGET1q7OIPYg">
-                      <Educts>
-                        <ReactionPartner stoichiometricCoefficient="1" partner="MnNILc-ThEuWb2MmUdz8QQ" />
-                      </Educts>
-                      <Products>
-                        <ReactionPartner stoichiometricCoefficient="1" partner="hlgv7zvAHkKE5uX9r2PHaA" />
-                      </Products>
-                      <ModifierNames>
-                        <ModifierNamesChild>Cyp</ModifierNamesChild>
-                      </ModifierNames>
-                    </Reaction>
-                  </Children>
-                </Container>
-                <Container id="zUyNSXS6uEitLMuf2-ef3Q" name="ColonAscendens" description="Colon Ascendens" icon="ColonAscendens" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="ColonAscendens" />
-                    <Tag value="Lumen" />
-                    <Tag value="LumenSegment" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="v3ylWGdl5ECp2fUWOFGUlQ" name="Thickness of gut wall" description="Thickness of Gut Wall" persistable="0" isFixedValue="0" formula="CrwFKdc0AkmmncutO67a1A" dim="Length" quantityType="0" />
-                    <Parameter id="AqqvrKw0mEq1g6iy5hQ47A" name="Absorption of liquid" description="rate of liquid outflow" persistable="0" isFixedValue="0" formula="3gNUqCzBFEKyae91Mar2Ng" dim="InversedTime" quantityType="0" />
-                    <Parameter id="TLknz2P5F0Ki7i3qYTXDmQ" name="Distal radius" description="Distal radius of intestinal segment" persistable="0" isFixedValue="0" formula="R46ArBLQ1US2Gb1bCChBmA" dim="Length" quantityType="0" />
-                    <Parameter id="-IuTKge1EEOG2A_UyrHFwg" name="FillLevelFlag" description="Fill Level Flag" persistable="0" isFixedValue="0" formula="pBby0d8e50ijLxI1Zd-y8A" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="Qu8Lp_D6-EauMjYidXxiPQ" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" persistable="0" isFixedValue="0" formula="SdN69bnvNEKeuk8z2n3lGQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="_a5a3nAwfkOdMaknuWsIpA" name="Geometric surface area" description="Geometric surface area of GI segment" persistable="0" isFixedValue="0" formula="ngGNoTJOo0KP78BsUQle0g" dim="Surface" quantityType="0" />
-                    <Parameter id="mXRfw2O2aU2hlinO6OJMbw" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" persistable="0" isFixedValue="0" formula="_g3GoRmt1k6g_755sYi7Xg" dim="InversedTime" quantityType="0" />
-                    <Parameter id="XirxUppTukWwcLuyc7gm0A" name="Length" description="Length" persistable="0" isFixedValue="0" formula="GC0lSgOyJUOIXmPp5q-wcg" dim="Length" quantityType="0" />
-                    <Parameter id="bGdSdW45XU-O45ZhNlCHSw" name="Liquid" description="Liquid" persistable="0" isFixedValue="0" formula="R6kHqMVgX0GtvICqeL6FFw" dim="Volume" quantityType="0" rHSFormula="ayLc_-Ed1EmtSh9H18XbSA" />
-                    <Parameter id="l5J2uDvHpkqkhkREQQ4E0w" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" persistable="0" isFixedValue="0" formula="7oafGajqHUaCXh-HWjAQbg" dim="Rate" quantityType="0" />
-                    <Parameter id="AZEov7w5ukGOqhxSCIU-Lg" name="Secretion of liquid" description="Rate of liquid inflow" persistable="0" isFixedValue="0" formula="PZcqit70TUyZf2P1t9BO8A" dim="Flow (volume)" quantityType="0" />
-                    <Parameter id="hSbPvUdwgk6jHD3hETmwgw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="xhED215POEuWycLJEijJ4Q" dim="Volume" quantityType="0" />
-                    <Parameter id="Kj8HGWeR6EaN3zKQb1rN_Q" name="Volume (gut wall)" description="Volume of the gut wall" persistable="0" isFixedValue="0" formula="1JjHOu_qXUCfLrDZjfqvTA" dim="Volume" quantityType="0" />
-                    <Parameter id="yCRdV5VXXUiFRgAOVyF1Tw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="owgI66XQcE2ClB4BHV50ew" dim="Volume" quantityType="0" />
-                    <Parameter id="-wir6sRlvkW0fIBzgLGjZg" name="Proximal radius" description="Proximal radius of intestinal segment" persistable="0" isFixedValue="0" formula="bOSpmtTi7k2o4j709TGn3A" dim="Length" quantityType="0" />
-                    <Parameter id="45YwPhe1xkWcC9WotACOCw" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="PpjJWjk1-kKXiS_hmEpDsA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="q1Q0M5J-JU-bIY66Berajg" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" formula="tn_QR4q8ukCFYdRtf8eGpA" dim="InversedLength" quantityType="0" />
-                    <Parameter id="acshprU8oUiyPvaFqqkxdw" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" formula="O_MdbgIv-UiXz0hQ-ZFLAA" dim="Length" quantityType="0" />
-                    <Parameter id="yEfi6f6duUOmtYagTvNHgw" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="UrMBmPgmbkmeX5nO5W_Uog" dim="Length" quantityType="0" />
-                    <Parameter id="8PQw13v1wkCco05Z_SRO1Q" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="JbakT-WTJkqpM9fsDcxBuw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="QMfcVS09pUyA6oLU12IO2A" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="ziyVuW0T3Eq2-blCSpOZZQ" dim="Length" quantityType="0" />
-                    <Parameter id="E6_WLucEiUajOTnMCmhGTw" name="pH" description="pH" persistable="0" isFixedValue="0" formula="8LAVbRyXCEqL4ofIdz27PQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="shky88SsKkOxKswnXlUs8A" name="Microvilli factor" description="Microvilli factor" persistable="0" isFixedValue="0" formula="e0CRGvUkXkmQGPT7mt6NyQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="BZfny1Q130Wkei7fQy_haA" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="RpYGyv6oLEOBMi_kEWueAQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="DUPAbxLVH02BkmVLMUksTg" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" formula="P3lzdNJ47UWPnDmsimhWVA" dim="Length" quantityType="0" />
-                    <Parameter id="UH53kTVw0kSselOBFY6Fiw" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" persistable="0" isFixedValue="0" formula="6f7FCj2DAEu0cyaM-CSmDw" dim="Fraction" quantityType="0" />
-                    <Parameter id="TIzuRIDSKEibmuwNNJuiTQ" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="CCZl75J0iEmsAtrfIfDReg" dim="Length" quantityType="0" />
-                    <Parameter id="NI1pgFdLa0Ki6UKrnQ3yyA" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" formula="YZsK4PtRSUmPgr7whaTHnA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="pt0YGpKa9024PjbwdwLxIw" name="Intestinal transit rate" description="Transit rate along intestinal segments" persistable="0" isFixedValue="0" formula="9-VrkJUXE0Si_LiAArQwXQ" dim="InversedTime" quantityType="0" />
-                    <MoleculeAmount id="jyt3cPowb0KjcfkF_O9aLA" name="Drug" icon="Drug" persistable="0" isFixedValue="0" formula="mmrTkI3eV0mdcdaDUPStoQ" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="zoGvv5pbEUqQpjYcfLT7xg" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Parameter id="ugSL_Mt6Z0alhYPT1iSOxA" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="6XSBrbHn6EK2Y9S6Uo8sMA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="4jRO8SP2_0qXcVbz_9KddA" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="9xk57bsJ0kqtO717umqqAw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="FrrLeW5xZEC-H5S4Cc6F7g" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="Yl3Cg2Xrzka6sBLU4SN5nA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="NbkHtIOsSUazCS0E_x2tmw" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" persistable="0" isFixedValue="0" formula="z8wTgk7osUO80fhzyDMgPA" dim="Amount" quantityType="0" rHSFormula="VR_2pqWgck6djAetskrnCg" />
-                        <Parameter id="zchQUa1qCE6JdIpZTUxh1g" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="z3tNWUzCmUGmLjIJp1ALJg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="6aUW4jvC50yXXOwM-TpqnQ" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="nRk6FjslPEugkHo2N6bZkg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="eIDaNO3ZwUGv2mrI4bBJrQ" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="DqwOeXQtEUyHiQhpOF41iA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="wq5PAgzYgkqk63iIbXUAWw" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" persistable="0" isFixedValue="0" formula="C_C-nGL3MEuvv5y8OnYqFA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="VghPcbh4YE-jtzXmUzSmLg" name="Solubility" description="Solubility" persistable="0" isFixedValue="0" formula="1WC8NKa3z0ikSvQqHy_CYw" dim="Concentration" quantityType="0" />
-                        <Parameter id="yT_79KcPOUqJ_dsj2oHsew" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="x4P5V9KTiki1Q1MRrKM3Wg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="yxGPDC9AfkeJ3DCGczS9zA" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="KyRsTlE6SEWcjC7ZKqdvlg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="ymGzQ6J4rU6IsJ4xcDJrMw" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="S_SM6CT7_0mqn_roS6eOMg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="EGWfeZjSk0qd_ci-Fi4pWA" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="18e0FGxhIUaqH29-C9W9mA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="XUVtPyHxqke3m-glUp0b-w" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IYEQix8cyUm7E8Vh7T5JlA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="pFW91U5CbkmVlXCauTAM2w" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="Au6XpfyfeEi3eXru-QSDaQ" dim="Dimensionless" quantityType="0" />
-                        <Observer id="UKfqfkD_BEe3NEcT6TalRA" name="Concentration in lumen" description="Concentration of the molecule in lumen" persistable="1" isFixedValue="0" formula="j43RhC6Wv0W0HJ9_uFMTPw" dim="MolarConcentration" quantityType="Drug, Observer" />
-                        <Observer id="rffSGNN4mUGYeFLmTnQ0oQ" name="Fraction of oral drug mass absorbed into mucosa segment" description="Fraction of oral drug mass absorbed into mucosa segment" persistable="1" isFixedValue="0" formula="5nbLuxyKsUig2MN-jcY9IA" dim="Fraction" quantityType="Drug, Observer" />
-                      </Children>
-                    </MoleculeAmount>
-                    <MoleculeAmount id="y7rwu9M9rk-zDkowAkbsSA" name="Cyp" icon="Enzyme" persistable="0" isFixedValue="0" formula="wb5yCXJZxUeVY_7iSBmoSg" dim="Amount" quantityType="Enzyme" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="NI_ObC666EewrFv7v3Tk9g" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" formula="z2wgS3Hp4ESA0-oo_SoKkg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="ItzCP7iTeECyCH11_l4m9A" name="Relative expression out." description="Relative Expression that will be used in the simulation" persistable="0" isFixedValue="0" formula="GtBZCb_uvUKgURPKDkyZKA" dim="Fraction" quantityType="0" />
-                        <Parameter id="wkNzTiejYEGhlYter8wR1A" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" persistable="0" isFixedValue="0" formula="IVNIQdKFr0ujLT8AS78yyQ" dim="Fraction" quantityType="0" />
-                        <Parameter id="nr4-C485pECMzFo4WdUSGQ" name="Relative expression" description="Relative expression" persistable="0" isFixedValue="0" formula="lptwKe15-UW14yquGO74vw" dim="Fraction" quantityType="0" />
-                        <Parameter id="MV7q8nd3kk2TAUdZc-jpbA" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                      </Children>
-                    </MoleculeAmount>
-                    <MoleculeAmount id="ZpugtfyRdE2I-0kaY9dZJw" name="Drug-Cyp Metabolite" persistable="0" isFixedValue="0" formula="Xd5-dPkD3kGSseHyHgxiSg" dim="Amount" quantityType="Metabolite" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="VKrZlJ37dkenJMtjGwthRg" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Observer id="oz5y3sQWg0yZUmKORU6-zw" name="Fraction of dose" description="Metabolized fraction of administered dose" persistable="1" isFixedValue="0" formula="aUoTQ3n3a0OShljd8bUj3w" dim="Fraction" quantityType="Metabolite, Observer" />
-                      </Children>
-                    </MoleculeAmount>
-                    <Reaction id="oLkZU_V0bE-017zZ-42Prw" name="Cyp-ME" icon="Metabolism" mode="Logical" containerType="Other" dimension="Dimensionless" formula="NrKgrsKmwkiGET1q7OIPYg">
-                      <Educts>
-                        <ReactionPartner stoichiometricCoefficient="1" partner="jyt3cPowb0KjcfkF_O9aLA" />
-                      </Educts>
-                      <Products>
-                        <ReactionPartner stoichiometricCoefficient="1" partner="ZpugtfyRdE2I-0kaY9dZJw" />
-                      </Products>
-                      <ModifierNames>
-                        <ModifierNamesChild>Cyp</ModifierNamesChild>
-                      </ModifierNames>
-                    </Reaction>
-                  </Children>
-                </Container>
-                <Container id="Rs3PRJYB9UKcgdddhyZaZg" name="ColonTransversum" description="Colon Transversum" icon="ColonTransversum" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="ColonTransversum" />
-                    <Tag value="Lumen" />
-                    <Tag value="LumenSegment" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="nTW5m6qxLkGHx5W0SrZ7uQ" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" persistable="0" isFixedValue="0" formula="A86Wx1CxikGar1xkoOfHAQ" dim="InversedTime" quantityType="0" />
-                    <Parameter id="-3nIMXVu1k6uB_OBmBE2Fw" name="Absorption of liquid" description="rate of liquid outflow" persistable="0" isFixedValue="0" formula="moZrusVzt0Cqqxm41YMhyw" dim="InversedTime" quantityType="0" />
-                    <Parameter id="Hw5Q1i290kGy4uqI5kBU7A" name="Distal radius" description="Distal radius of intestinal segment" persistable="0" isFixedValue="0" formula="R46ArBLQ1US2Gb1bCChBmA" dim="Length" quantityType="0" />
-                    <Parameter id="0V1KGRlSoEm9_De2Cns8XQ" name="FillLevelFlag" description="Fill Level Flag" persistable="0" isFixedValue="0" formula="pBby0d8e50ijLxI1Zd-y8A" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="u4e6-DzG9UiVuVVUy-Osbg" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" persistable="0" isFixedValue="0" formula="SdN69bnvNEKeuk8z2n3lGQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="79SuKjctJUidyJFT3FP7bA" name="Length" description="Length" persistable="0" isFixedValue="0" formula="GC0lSgOyJUOIXmPp5q-wcg" dim="Length" quantityType="0" />
-                    <Parameter id="UKa3d7wK_EaDspc_VxTybg" name="Geometric surface area" description="Geometric surface area of GI segment" persistable="0" isFixedValue="0" formula="ngGNoTJOo0KP78BsUQle0g" dim="Surface" quantityType="0" />
-                    <Parameter id="BUrB5pGKC063hwb_yxomWQ" name="Liquid" description="Liquid" persistable="0" isFixedValue="0" formula="R6kHqMVgX0GtvICqeL6FFw" dim="Volume" quantityType="0" rHSFormula="pw5guo7EZECJlp_U2OgseQ" />
-                    <Parameter id="EpnskszfXkGBs0PRyTDizQ" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" persistable="0" isFixedValue="0" formula="LWkyuTA7DUOqqbaA-5UJBg" dim="Rate" quantityType="0" />
-                    <Parameter id="tLKsrmsjkkC5gh2iYeoE7w" name="Proximal radius" description="Proximal radius of intestinal segment" persistable="0" isFixedValue="0" formula="bOSpmtTi7k2o4j709TGn3A" dim="Length" quantityType="0" />
-                    <Parameter id="XFdECaO8LUOq8eaUmxB6MQ" name="Secretion of liquid" description="Rate of liquid inflow" persistable="0" isFixedValue="0" formula="hInJxwKqn0Gt3neZvM_GsQ" dim="Flow (volume)" quantityType="0" />
-                    <Parameter id="Fx0Ke3lEJ0O-shAbfgL_lw" name="Thickness of gut wall" description="Thickness of Gut Wall" persistable="0" isFixedValue="0" formula="CrwFKdc0AkmmncutO67a1A" dim="Length" quantityType="0" />
-                    <Parameter id="-W_gWW-410C2-vyk4uNHzA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="xhED215POEuWycLJEijJ4Q" dim="Volume" quantityType="0" />
-                    <Parameter id="RWTm1_XsbU-6JG3y7IurIQ" name="Volume (gut wall)" description="Volume of the gut wall" persistable="0" isFixedValue="0" formula="1JjHOu_qXUCfLrDZjfqvTA" dim="Volume" quantityType="0" />
-                    <Parameter id="I7qJEbGRv0-NKxIEKw1FRg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="owgI66XQcE2ClB4BHV50ew" dim="Volume" quantityType="0" />
-                    <Parameter id="uptQZrbu6UiEtRJFRtghTw" name="Intestinal transit rate" description="Transit rate along intestinal segments" persistable="0" isFixedValue="0" formula="95RFxEwpKEST-v33i5Fo5g" dim="InversedTime" quantityType="0" />
-                    <Parameter id="DEcvcgvU3EO65cVLHLY-rA" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" persistable="0" isFixedValue="0" formula="MivdLpKbcUeEnDCwe3R7kQ" dim="Fraction" quantityType="0" />
-                    <Parameter id="Mf_kgoK_EUK1RvDvaknHyA" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" formula="n_TA5203qUmwUyLHSnRMfg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="wfQNVgRtJkyPRytnpnoyig" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="pD_RG8nH9UC9zCUgF7-rHQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="XmsQdByY3UO5CYJlivw5Kw" name="Microvilli factor" description="Microvilli factor" persistable="0" isFixedValue="0" formula="p_dRQ9xHhUetjwTQjoUOGA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="7M35enyAi022AL5zj_wdCw" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" formula="e6f_kJRAoke0kOUG6AKPCA" dim="Length" quantityType="0" />
-                    <Parameter id="cY6lYL408kCJ3Ni-xHRdrw" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="g7cL14tegUex3p-7Bs_k4A" dim="Length" quantityType="0" />
-                    <Parameter id="dGoPuq9WDE-v2LhERNP1Uw" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" formula="rfejEXNKw0KwXOFgsV5fpQ" dim="InversedLength" quantityType="0" />
-                    <Parameter id="SZalJWinxE-2gNiGzDhdig" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" formula="FLEYQyn88kq1zOgZBmv5Uw" dim="Length" quantityType="0" />
-                    <Parameter id="YedkChaU3kKP0r8kscx6pg" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="MeQL2pnPKkiO0z6trtBHsQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="HaSjOzzKvUy1UP5zRloG4w" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="ENbPwy9m7UelxHvk5qWjhw" dim="Length" quantityType="0" />
-                    <Parameter id="xE7SHSGv_kOqRXHuTZ49Ng" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="wnSYDYAB50y238vz5mQ4Ag" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="tM7bXmEcgkSS8u8bX5b1sw" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="z6NKA4uyg0qcdIPMVQb7dA" dim="Length" quantityType="0" />
-                    <Parameter id="UfjlEMBF3kOUZ0gtUEnnfQ" name="pH" description="pH" persistable="0" isFixedValue="0" formula="hpMpYEIASkyKtmbzrYd1hw" dim="Dimensionless" quantityType="0" />
-                    <MoleculeAmount id="bRBIqa0pgkWCj0_OcRNkPA" name="Drug" icon="Drug" persistable="0" isFixedValue="0" formula="zZz9SnU_HkaGmaZvOVoNvA" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="H9XYOgUVKUeHF7_iudODow" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Parameter id="dEShCy7n4EG4HQhvfUr0jA" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="vhRQbsfHaEWS4xsEJH6YDQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="pmaDeY4fnUWM4lDr7SrCZQ" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" persistable="0" isFixedValue="0" formula="GgkatGebBU-wgACFV03hPA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="oGUyXZfAQUyrEJR__ywcCg" name="Solubility" description="Solubility" persistable="0" isFixedValue="0" formula="8idDY7c6qE2I8WpaNqaBoQ" dim="Concentration" quantityType="0" />
-                        <Parameter id="f0dPE2Ixz02ohG3PYehM7A" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="dJUsoN17dkqp44UFuPLkhw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="6sprQuO6bUqwXanRPxI42A" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="0vgdBTS6a06mcJfyuN0oUQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="KKcDcuAJnE20y860BgUF0w" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="Ub9afLEw402iwnw_35tsJw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="SLEXFztXDkaQ9-LvO4K5rg" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="KzKIZ5izIUyDdS-kTYKRzw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="avRo_LWb5kqKNvNO1dUWUA" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="AEwHlNmNK0-nEBLNx71aTw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="aTXT2MEa8kuhT_POV2J_lw" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="UwTvLoNtkEqOH2xpweZOsg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="0zo3dPRXIUSPC-JMOrHxVA" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="9rbdQHi0HUyjA5BAwVvkLQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="JomlZ3PIcU-RU7EEKlnF3g" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="L0pxzqb5TkCShhYNCoRTLA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="BdtKOMj8g0aftB_VhjURdA" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="apibLTIfzE2EWHp18XRtGg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="BQgBaDNh20KVuYwV8ThqFA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="i4B0Hn9dGUOP4De2cCXsxg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="5rbRLlrGSUK0SvtRs7JG1g" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" persistable="0" isFixedValue="0" formula="exMkUrc9kEauUgVS_x8BPg" dim="Amount" quantityType="0" rHSFormula="KOI7RBdArUWhjCEL0C0jWw" />
-                        <Parameter id="oHorcALSSUKdJfXRtq2KbQ" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="61sDuQm7w0GakLxLtTArYg" dim="Dimensionless" quantityType="0" />
-                        <Observer id="nJgqj6tjkkanciGPb1lvpw" name="Concentration in lumen" description="Concentration of the molecule in lumen" persistable="1" isFixedValue="0" formula="j43RhC6Wv0W0HJ9_uFMTPw" dim="MolarConcentration" quantityType="Drug, Observer" />
-                        <Observer id="MJzBRTLo3Ee9Y6ouXqwRNA" name="Fraction of oral drug mass absorbed into mucosa segment" description="Fraction of oral drug mass absorbed into mucosa segment" persistable="1" isFixedValue="0" formula="5nbLuxyKsUig2MN-jcY9IA" dim="Fraction" quantityType="Drug, Observer" />
-                      </Children>
-                    </MoleculeAmount>
-                    <MoleculeAmount id="sTq3LD7Yb0ikk9TtkBidpg" name="Cyp" icon="Enzyme" persistable="0" isFixedValue="0" formula="wb5yCXJZxUeVY_7iSBmoSg" dim="Amount" quantityType="Enzyme" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="vICFc2q0A0-vMjbLGaQRZg" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" formula="RVz23eASmEan01V1SR_Z4A" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="GwNuQQYFgU-ffJycBjq6Xw" name="Relative expression out." description="Relative Expression that will be used in the simulation" persistable="0" isFixedValue="0" formula="GtBZCb_uvUKgURPKDkyZKA" dim="Fraction" quantityType="0" />
-                        <Parameter id="7whKqsAhAEKKdjb4U19qxw" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" persistable="0" isFixedValue="0" formula="DueZfjlxbkmydthhCqbIUg" dim="Fraction" quantityType="0" />
-                        <Parameter id="SVziEVo31E6qaNNa7XNLoQ" name="Relative expression" description="Relative expression" persistable="0" isFixedValue="0" formula="XoZks4UtAkCq9-C2T5B9kQ" dim="Fraction" quantityType="0" />
-                        <Parameter id="hodElF9s-0qE7M4wSIr8FQ" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                      </Children>
-                    </MoleculeAmount>
-                    <MoleculeAmount id="V_QtbLGWek-UEtqaQ7jBdA" name="Drug-Cyp Metabolite" persistable="0" isFixedValue="0" formula="1MX8SJKMhkekbG03dg0I-Q" dim="Amount" quantityType="Metabolite" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="U-3BrILafU2ZOXjHfmnBug" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Observer id="_nh5yJXuMUmM4JYaqjN-dQ" name="Fraction of dose" description="Metabolized fraction of administered dose" persistable="1" isFixedValue="0" formula="aUoTQ3n3a0OShljd8bUj3w" dim="Fraction" quantityType="Metabolite, Observer" />
-                      </Children>
-                    </MoleculeAmount>
-                    <Reaction id="zQduU0XNokK3XfYSvfy7pA" name="Cyp-ME" icon="Metabolism" mode="Logical" containerType="Other" dimension="Dimensionless" formula="NrKgrsKmwkiGET1q7OIPYg">
-                      <Educts>
-                        <ReactionPartner stoichiometricCoefficient="1" partner="bRBIqa0pgkWCj0_OcRNkPA" />
-                      </Educts>
-                      <Products>
-                        <ReactionPartner stoichiometricCoefficient="1" partner="V_QtbLGWek-UEtqaQ7jBdA" />
-                      </Products>
-                      <ModifierNames>
-                        <ModifierNamesChild>Cyp</ModifierNamesChild>
-                      </ModifierNames>
-                    </Reaction>
-                  </Children>
-                </Container>
-                <Container id="9jArwMBpW06x34mUf4QukQ" name="ColonDescendens" description="Colon Descendens / Distal Colon 1" icon="ColonDescendens" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="ColonDescendens" />
-                    <Tag value="Lumen" />
-                    <Tag value="LumenSegment" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="lgVLYWHsvESYC3BdqHMGvQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="owgI66XQcE2ClB4BHV50ew" dim="Volume" quantityType="0" />
-                    <Parameter id="auutaGK7sUmbbkKe6atziA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="xhED215POEuWycLJEijJ4Q" dim="Volume" quantityType="0" />
-                    <Parameter id="zeDJs_tHhEC17AQk2_uBMQ" name="FillLevelFlag" description="Fill Level Flag" persistable="0" isFixedValue="0" formula="pBby0d8e50ijLxI1Zd-y8A" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="MHS4KYFu8UyVsCrRZPQ3qA" name="Volume (gut wall)" description="Volume of the gut wall" persistable="0" isFixedValue="0" formula="1JjHOu_qXUCfLrDZjfqvTA" dim="Volume" quantityType="0" />
-                    <Parameter id="UR8Jr-vp2ECn094B2W5p-g" name="Distal radius" description="Distal radius of intestinal segment" persistable="0" isFixedValue="0" formula="R46ArBLQ1US2Gb1bCChBmA" dim="Length" quantityType="0" />
-                    <Parameter id="XvSCMzaGd0eqKYShenemeA" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" persistable="0" isFixedValue="0" formula="SdN69bnvNEKeuk8z2n3lGQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="UeE5qLHrekSF5ZMFNaGCbQ" name="Geometric surface area" description="Geometric surface area of GI segment" persistable="0" isFixedValue="0" formula="ngGNoTJOo0KP78BsUQle0g" dim="Surface" quantityType="0" />
-                    <Parameter id="5-r3TUqKQE6yCo7mf9Yehg" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" persistable="0" isFixedValue="0" formula="KlLT4g_PK0OpqEyohyifIA" dim="InversedTime" quantityType="0" />
-                    <Parameter id="KRRb__O4M0CiCqUj991kjQ" name="Length" description="Length" persistable="0" isFixedValue="0" formula="GC0lSgOyJUOIXmPp5q-wcg" dim="Length" quantityType="0" />
-                    <Parameter id="be67SvjA4kO1sb78PoJQDA" name="Liquid" description="Liquid" persistable="0" isFixedValue="0" formula="R6kHqMVgX0GtvICqeL6FFw" dim="Volume" quantityType="0" rHSFormula="XEfgQYufQ0KP4COVGc6Vxg" />
-                    <Parameter id="ZjFmj3ENvUayDU3nntPgCA" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" persistable="0" isFixedValue="0" formula="bIWPEes42k2VAM6pAjcc4Q" dim="Rate" quantityType="0" />
-                    <Parameter id="K4X5vv-qekeCbhYdvNGraQ" name="Proximal radius" description="Proximal radius of intestinal segment" persistable="0" isFixedValue="0" formula="bOSpmtTi7k2o4j709TGn3A" dim="Length" quantityType="0" />
-                    <Parameter id="tnAcvKb5zUi7McWV4N81Cg" name="Secretion of liquid" description="Rate of liquid inflow" persistable="0" isFixedValue="0" formula="306Zj3K2nkeDvArR_5AX9w" dim="Flow (volume)" quantityType="0" />
-                    <Parameter id="ldvCQiv5g0GcC35tyqFz8Q" name="Thickness of gut wall" description="Thickness of Gut Wall" persistable="0" isFixedValue="0" formula="CrwFKdc0AkmmncutO67a1A" dim="Length" quantityType="0" />
-                    <Parameter id="hqd803z_602TeEXRXyI5UA" name="Absorption of liquid" description="rate of liquid outflow" persistable="0" isFixedValue="0" formula="-ThPdjHMNUiUZynIrZzGWg" dim="InversedTime" quantityType="0" />
-                    <Parameter id="8WaTyfooDEyqKpF5noMynw" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="xgEiZZ0k1EOEBqSrxdqncQ" dim="Length" quantityType="0" />
-                    <Parameter id="Bpr7TC-6_0OqMyg-X-P-Kw" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" formula="H-KufmeA20e3RLhQZvibgA" dim="InversedLength" quantityType="0" />
-                    <Parameter id="I5EcAbO7_Uy7Ad8Ld9W-vw" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" formula="osTOmwgPlke6HyB79cTvuA" dim="Length" quantityType="0" />
-                    <Parameter id="zRa0JEj8Y0KEjfVB1YehKw" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" formula="4zaAMxXU50yxsHHhuNsk5w" dim="Length" quantityType="0" />
-                    <Parameter id="5CDbgs4xyEeIHkqyInBn1Q" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="mynmzDOZhk6HJbhrVUy1gQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="o9viAxce4kG0Vv5SCvU7jw" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="0-oY9jZYf0Gsnh6sWAk2AQ" dim="Length" quantityType="0" />
-                    <Parameter id="NMka-6RmfkOHdKP6MWu_3w" name="pH" description="pH" persistable="0" isFixedValue="0" formula="S__cdLb3_U2fYwPU34hxKg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="DnxlBa3t9EWI1lLwLkYf4w" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="QG_2GS6r9UO0bqLIZXG8hQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="Hgxrig-uOUe30WTJv1IL9w" name="Microvilli factor" description="Microvilli factor" persistable="0" isFixedValue="0" formula="lZL90A7n2EiaM7SFzEVU9w" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="rR5a-Sw7j0OELKPBPT9ejg" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="6jC0qvhl-EGrP-ddT7Pf7A" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="a2lDdhKvuUafsSmY2bxKSw" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="W2faLVqlP0ayIvT4QMmNQQ" dim="Length" quantityType="0" />
-                    <Parameter id="RKW5IHnaEE-pBsLwuBa7Rg" name="Intestinal transit rate" description="Transit rate along intestinal segments" persistable="0" isFixedValue="0" formula="HemYkRATskiq194jyznzOw" dim="InversedTime" quantityType="0" />
-                    <Parameter id="nU6Pa--GDEGiU8k6AA4YGw" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" persistable="0" isFixedValue="0" formula="eEixkOee5EeIFjB5jIf3eA" dim="Fraction" quantityType="0" />
-                    <Parameter id="haZ7RrBMNUyHLBEhtJ2-wQ" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" formula="cq4v3m1kjk6QWuY4gm47aA" dim="Dimensionless" quantityType="0" />
-                    <MoleculeAmount id="NcJB6NUxaEGwgdsFjtyx4w" name="Drug" icon="Drug" persistable="0" isFixedValue="0" formula="vzdOXpk29Uy7sQhRtlt45Q" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="6tGLl27Bl02dWB1UqoOxLA" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Parameter id="un7JER_WrEqW6FGy5zcMGQ" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="UPXt0_AP70qXuYoaNp4MVQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="-ylSmH08KUmdjjmzVy5tLQ" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" persistable="0" isFixedValue="0" formula="c0va08aIuUOl4ZO0KmADBw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="Ppt8dGPSJ0uU2DnOVHXnoQ" name="Solubility" description="Solubility" persistable="0" isFixedValue="0" formula="HhFtsFYLFUKHRPzK_PGzig" dim="Concentration" quantityType="0" />
-                        <Parameter id="qhPo9KWtsU63tzKPwV8hnA" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="3CuXp7ClckWx0ocNUGmJqw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="6iBCi-JNv0aRZonUrVM9mQ" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="BpYYG5PGt06s213ARIOTqw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="1RDllGsgS0q4SicJT_qOrw" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="4e21lExWVEq3GqfVuOQADQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="IqVVLb4pYE2wmnBmLlQQvA" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="0gLVa5sBE0uUM1UMv8olLQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="L7ZihVwBt0mVnr4E_ZHnTw" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="RilDugXWUk6dF07cKVaDQQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="WBHDN90UGkiBJws3BH8I3Q" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="ugaq-EZzA0eAyb7ngNPdfQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="-CH2LmV1eU2PTTL3NhD1kw" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="_mL2NKF_UkmcxhHeoJnCSw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="QA3kss-NZEqnPVe1G0WaRw" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="6no67oojXkiXMYSfmG5Q0Q" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="co18SXzdEk-axFeyhrbDTQ" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="CpCPip8TXkKooGUVHdKLfw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="xEmZ4rUPv0CSF5qpsb0PJA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="M3kqXAC0W0qzg-CDIrpymw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="RVUG91xR0UKEczEoKAeTkA" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" persistable="0" isFixedValue="0" formula="mw6a05IPD0iWgyjXxKt4eA" dim="Amount" quantityType="0" rHSFormula="nW2IA77cfkCieZeV01bZ_g" />
-                        <Parameter id="RxJO3ATbj0mNkmsBemkpUw" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="QSRyQE1vuEGXWD55igyCQg" dim="Dimensionless" quantityType="0" />
-                        <Observer id="BpLIlyBeWEm9M-J0uvNCIQ" name="Concentration in lumen" description="Concentration of the molecule in lumen" persistable="1" isFixedValue="0" formula="j43RhC6Wv0W0HJ9_uFMTPw" dim="MolarConcentration" quantityType="Drug, Observer" />
-                        <Observer id="qsMd-3uVKkWtMIDzKcFpgw" name="Fraction of oral drug mass absorbed into mucosa segment" description="Fraction of oral drug mass absorbed into mucosa segment" persistable="1" isFixedValue="0" formula="5nbLuxyKsUig2MN-jcY9IA" dim="Fraction" quantityType="Drug, Observer" />
-                      </Children>
-                    </MoleculeAmount>
-                    <MoleculeAmount id="nobAifJUY0KLqOmPfVHnyA" name="Cyp" icon="Enzyme" persistable="0" isFixedValue="0" formula="wb5yCXJZxUeVY_7iSBmoSg" dim="Amount" quantityType="Enzyme" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="UIi0js1YB0aRLcU2PuLvfQ" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" formula="MkTFj4dMskSottWGzQQweA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="yhvlDxwuwEiw4ZD8K0Ixlg" name="Relative expression out." description="Relative Expression that will be used in the simulation" persistable="0" isFixedValue="0" formula="GtBZCb_uvUKgURPKDkyZKA" dim="Fraction" quantityType="0" />
-                        <Parameter id="Z9LrnJklWkeNVLG4m7RvaQ" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" persistable="0" isFixedValue="0" formula="P1APnoIlAkqKhy5akpaTcg" dim="Fraction" quantityType="0" />
-                        <Parameter id="-n1lI5BAOEe3ygA1xYE-jg" name="Relative expression" description="Relative expression" persistable="0" isFixedValue="0" formula="_MYVWRtMSk29HnDYU4gkig" dim="Fraction" quantityType="0" />
-                        <Parameter id="A7OZ2pslekmRiztTL6WvlQ" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                      </Children>
-                    </MoleculeAmount>
-                    <MoleculeAmount id="EWJFZUvTbUml4QQyxVVvBA" name="Drug-Cyp Metabolite" persistable="0" isFixedValue="0" formula="yQ56GgTFBEG_9l7b-o_0fA" dim="Amount" quantityType="Metabolite" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="pJ9PVhICaEe3CeSSqGQH1Q" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Observer id="47a93RuGaEGA9gXWSlN6LA" name="Fraction of dose" description="Metabolized fraction of administered dose" persistable="1" isFixedValue="0" formula="aUoTQ3n3a0OShljd8bUj3w" dim="Fraction" quantityType="Metabolite, Observer" />
-                      </Children>
-                    </MoleculeAmount>
-                    <Reaction id="x9XJPgSAI06weOpUNJH4xA" name="Cyp-ME" icon="Metabolism" mode="Logical" containerType="Other" dimension="Dimensionless" formula="NrKgrsKmwkiGET1q7OIPYg">
-                      <Educts>
-                        <ReactionPartner stoichiometricCoefficient="1" partner="NcJB6NUxaEGwgdsFjtyx4w" />
-                      </Educts>
-                      <Products>
-                        <ReactionPartner stoichiometricCoefficient="1" partner="EWJFZUvTbUml4QQyxVVvBA" />
-                      </Products>
-                      <ModifierNames>
-                        <ModifierNamesChild>Cyp</ModifierNamesChild>
-                      </ModifierNames>
-                    </Reaction>
-                  </Children>
-                </Container>
-                <Container id="t9buGgr6O02MMqVEqnLjgQ" name="ColonSigmoid" description="Colon Sigmoid / Distal Colon 2" icon="ColonSigmoid" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="ColonSigmoid" />
-                    <Tag value="Lumen" />
-                    <Tag value="LumenSegment" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="e_9hPfqTYkWa3Rz85HQorw" name="Secretion of liquid" description="Rate of liquid inflow" persistable="0" isFixedValue="0" formula="SRecG7mO50abXnYMA8xCaw" dim="Flow (volume)" quantityType="0" />
-                    <Parameter id="WEcHREHIwUW946kZEBvxlQ" name="Absorption of liquid" description="rate of liquid outflow" persistable="0" isFixedValue="0" formula="Xavw3vbF2Uyruw_IMCeO9A" dim="InversedTime" quantityType="0" />
-                    <Parameter id="OKLWIrfmD0mJvfMOBjxuUw" name="Distal radius" description="Distal radius of intestinal segment" persistable="0" isFixedValue="0" formula="R46ArBLQ1US2Gb1bCChBmA" dim="Length" quantityType="0" />
-                    <Parameter id="w3XyjbEc4UCIYPv1RB4baw" name="FillLevelFlag" description="Fill Level Flag" persistable="0" isFixedValue="0" formula="pBby0d8e50ijLxI1Zd-y8A" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="fgmIUbL1vUuy9fBB4qC1tg" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" persistable="0" isFixedValue="0" formula="SdN69bnvNEKeuk8z2n3lGQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="HhWtYZOqp0q5D_tl63dJzA" name="Geometric surface area" description="Geometric surface area of GI segment" persistable="0" isFixedValue="0" formula="ngGNoTJOo0KP78BsUQle0g" dim="Surface" quantityType="0" />
-                    <Parameter id="aAtNhQR-r0S8niCZdVUYlg" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" persistable="0" isFixedValue="0" formula="KlFSrsqCUkywFefQBjCwwQ" dim="InversedTime" quantityType="0" />
-                    <Parameter id="wjMqXZkxCUaK3gLpM2aaQw" name="Length" description="Length" persistable="0" isFixedValue="0" formula="GC0lSgOyJUOIXmPp5q-wcg" dim="Length" quantityType="0" />
-                    <Parameter id="pxOjzeN10kym0TPbyxDrCQ" name="Liquid" description="Liquid" persistable="0" isFixedValue="0" formula="R6kHqMVgX0GtvICqeL6FFw" dim="Volume" quantityType="0" rHSFormula="mboJhD-XVUamapvMK2DMSg" />
-                    <Parameter id="pm9k6RhdokS-_164sGkkyw" name="Proximal radius" description="Proximal radius of intestinal segment" persistable="0" isFixedValue="0" formula="bOSpmtTi7k2o4j709TGn3A" dim="Length" quantityType="0" />
-                    <Parameter id="TgqFgTBO6kyclBGbWwp4Ig" name="Thickness of gut wall" description="Thickness of Gut Wall" persistable="0" isFixedValue="0" formula="CrwFKdc0AkmmncutO67a1A" dim="Length" quantityType="0" />
-                    <Parameter id="nd0hN94dO0ym0LqtE-pYXA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="xhED215POEuWycLJEijJ4Q" dim="Volume" quantityType="0" />
-                    <Parameter id="VIJ_GDzvBUOn3PVgBBlehA" name="Volume (gut wall)" description="Volume of the gut wall" persistable="0" isFixedValue="0" formula="1JjHOu_qXUCfLrDZjfqvTA" dim="Volume" quantityType="0" />
-                    <Parameter id="ldrVB05H4UCUGtDvsu3SKQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="owgI66XQcE2ClB4BHV50ew" dim="Volume" quantityType="0" />
-                    <Parameter id="PNq4TCsfBU2s67QQzvToWw" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" persistable="0" isFixedValue="0" formula="H4TdhW-rnkeQxupaqKrYNg" dim="Rate" quantityType="0" />
-                    <Parameter id="vJ1n2qWFnky1gH-6UbrdPA" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" formula="WsZJh2dYE0ebov-QCJh24Q" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="xPeG7saZb0-ACJWA8hiUQw" name="pH" description="pH" persistable="0" isFixedValue="0" formula="Tol-Q7vx1EK3KQrdHYj4uw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="N8xkD-E3kESKK-G5OW6fUg" name="Microvilli factor" description="Microvilli factor" persistable="0" isFixedValue="0" formula="HZccZfcgRU6ccLhP7mxayA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="HxQTrS3q5EClanDIcmezFg" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="emwsanpOlkuP5jZmH9Jc8w" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="c6ijyiKTk0OO7SeUGEiTAg" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="Iv5uUhfsvEi8Xes9OiH-gQ" dim="Length" quantityType="0" />
-                    <Parameter id="sF1P5dfqjU6J5xawCng5uw" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="in2uDWEeSESbiBrBmcBGXg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="wbzSMx_gP0mu-4YFMUGubQ" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" persistable="0" isFixedValue="0" formula="boxjDChPWEOA6pOypYwebg" dim="Fraction" quantityType="0" />
-                    <Parameter id="jh4OgIlyXUirdHE1VLfgHQ" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="QKbQ3mRqwUmKVe7FuT9D1A" dim="Length" quantityType="0" />
-                    <Parameter id="BOHS4pZdWUm9ogtGqdxRqw" name="Intestinal transit rate" description="Transit rate along intestinal segments" persistable="0" isFixedValue="0" formula="qVT8R_tV0kOtgFkQiuZPSQ" dim="InversedTime" quantityType="0" />
-                    <Parameter id="hCsDRyQBqEqItVCY4OexjQ" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="bn9OnheQyUe2sdYjuTGpgw" dim="Length" quantityType="0" />
-                    <Parameter id="5B0Z6eBrSkO59LBj-mRbRg" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" formula="GZRT-bqPkkax9G51pSbt9Q" dim="InversedLength" quantityType="0" />
-                    <Parameter id="Xs3VP-Zf4EO2fkWcqmJfDQ" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" formula="V1e2vU2wRku8BxcA_9u_Iw" dim="Length" quantityType="0" />
-                    <Parameter id="L7DmtpE-7EOd-HAe2QomtA" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" formula="uTLUkplCJUGioHKvLl8ASQ" dim="Length" quantityType="0" />
-                    <Parameter id="Tus71cWxxU61jRg3LVt5rA" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="wktdczNHRUCendkpya_0vA" dim="Dimensionless" quantityType="0" />
-                    <MoleculeAmount id="zyEivk-9f02yySFoyDYMYQ" name="Drug" icon="Drug" persistable="0" isFixedValue="0" formula="bPlsu-5KpkefQfTiV9m4OA" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="wTLSnZ4L2UqsP6n-1wuH2Q" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Parameter id="AEffRnEQtUanSEOEStAFgA" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" persistable="0" isFixedValue="0" formula="yGKit7S_EUKp8VSq4i0UCg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="F0HrFmWN-kqpeRNxCMM1Hw" name="Solubility" description="Solubility" persistable="0" isFixedValue="0" formula="Klu4p6mHb0Gwth7R57qr9A" dim="Concentration" quantityType="0" />
-                        <Parameter id="Sabc5CoIlkOp0mQv3kBOOQ" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="ZRbNMw1KtECCecS5AxVgow" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="1MvQkaRb60SnOVDAqkQLyQ" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="cKFRLAMJB0KQP3xSOyDVYg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="GY0asPSpskae-Z2mQoBg3Q" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="8PVEGbhwpk-kUGMWqVkcEg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="Y3ovFg6eP0CX6nn2mA91Ww" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="ijlNAcuEcECcHSKxp3-pPQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="tnWVBVDRLk6fgGf0p3AI1w" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="YoU_Muzl7UqQ8cMF2VTsKg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="NpnFHN2OLEqkx5jULaCfIw" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="0x7LwCTEO06EP8rfstrN6w" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="0L-iETWtyUOwK99VEGeh7Q" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="z7uxtrbMO0O5dP280JgFYw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="o5OzeHtJ_0K3X-sFrHVtwg" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="tA_ds1WSvEWtXyJez6RK4Q" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="d4142Z_ml06g9NACc2mh2w" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="DqlovrzdjUWhSvqh5r3YVw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="eN7pK3ok8kS6QEilRcg_4w" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="A808EGbvO0Kqda8PfF7xSQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="qzWafqRN3kKmmMgFwXC9AQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="SZQpl1KnvUWWBtOh-Ny-Eg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="ARbKp2rQ1Uy7lDIhjmPIeA" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" persistable="0" isFixedValue="0" formula="YyN3jbQ3Ek-nk5GYA9T17g" dim="Amount" quantityType="0" rHSFormula="ptTtF6iI1USY3WdrlsvmwQ" />
-                        <Parameter id="97PcRVBSA0iYax-6Z5NXbw" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="5vQuOEbE1UmD0MEEz3rDcw" dim="Dimensionless" quantityType="0" />
-                        <Observer id="-c-Qt52-C0OuumNcz_R5IA" name="Concentration in lumen" description="Concentration of the molecule in lumen" persistable="1" isFixedValue="0" formula="j43RhC6Wv0W0HJ9_uFMTPw" dim="MolarConcentration" quantityType="Drug, Observer" />
-                        <Observer id="PeVO-QAv6k-T6ylQmXJJWQ" name="Fraction of oral drug mass absorbed into mucosa segment" description="Fraction of oral drug mass absorbed into mucosa segment" persistable="1" isFixedValue="0" formula="5nbLuxyKsUig2MN-jcY9IA" dim="Fraction" quantityType="Drug, Observer" />
-                      </Children>
-                    </MoleculeAmount>
-                    <MoleculeAmount id="Jl8q1Y-Y2Eqg9vd8S4jRxA" name="Cyp" icon="Enzyme" persistable="0" isFixedValue="0" formula="wb5yCXJZxUeVY_7iSBmoSg" dim="Amount" quantityType="Enzyme" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="qXSm07SlSECfK8t21lV5wg" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" formula="JkjeDltvO0GFmeBKdTxOpw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="EgNuBBKCxkqVUiBey1rnKA" name="Relative expression out." description="Relative Expression that will be used in the simulation" persistable="0" isFixedValue="0" formula="GtBZCb_uvUKgURPKDkyZKA" dim="Fraction" quantityType="0" />
-                        <Parameter id="Ojf9M84LlkG80UgPZGDYxg" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" persistable="0" isFixedValue="0" formula="pCEf8zEKw0-CmV-Qev75bw" dim="Fraction" quantityType="0" />
-                        <Parameter id="nNBU_cOtaUG9u__q8n3AKA" name="Relative expression" description="Relative expression" persistable="0" isFixedValue="0" formula="BRtvkMeMHU6E9fSI_cQD4Q" dim="Fraction" quantityType="0" />
-                        <Parameter id="RSsuyCvkzEWZRQP0DzZCuA" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                      </Children>
-                    </MoleculeAmount>
-                    <MoleculeAmount id="D0Jmj6auhkKrH-sIWrhGeQ" name="Drug-Cyp Metabolite" persistable="0" isFixedValue="0" formula="NGUtVpYI8kOJkxuMfwNGlQ" dim="Amount" quantityType="Metabolite" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="tB7bXJBgEUSE1QqXxgHfOQ" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Observer id="vwM8P5bl60GVxVhgxTj8Ew" name="Fraction of dose" description="Metabolized fraction of administered dose" persistable="1" isFixedValue="0" formula="aUoTQ3n3a0OShljd8bUj3w" dim="Fraction" quantityType="Metabolite, Observer" />
-                      </Children>
-                    </MoleculeAmount>
-                    <Reaction id="oe7xMR_0S0ar8AQha3ENmw" name="Cyp-ME" icon="Metabolism" mode="Logical" containerType="Other" dimension="Dimensionless" formula="NrKgrsKmwkiGET1q7OIPYg">
-                      <Educts>
-                        <ReactionPartner stoichiometricCoefficient="1" partner="zyEivk-9f02yySFoyDYMYQ" />
-                      </Educts>
-                      <Products>
-                        <ReactionPartner stoichiometricCoefficient="1" partner="D0Jmj6auhkKrH-sIWrhGeQ" />
-                      </Products>
-                      <ModifierNames>
-                        <ModifierNamesChild>Cyp</ModifierNamesChild>
-                      </ModifierNames>
-                    </Reaction>
-                  </Children>
-                </Container>
-                <Container id="OMeI603lPki93VUfJyqQow" name="Rectum" description="Rectum" icon="Rectum" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Rectum" />
-                    <Tag value="Lumen" />
-                    <Tag value="LumenSegment" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="lEM18aGBX0qcPRoDcS5RMA" name="Geometric surface area" description="Geometric surface area of GI segment" persistable="0" isFixedValue="0" formula="ngGNoTJOo0KP78BsUQle0g" dim="Surface" quantityType="0" />
-                    <Parameter id="0jt7svIIEEqShpR_N-EiFQ" name="Absorption of liquid" description="rate of liquid outflow" persistable="0" isFixedValue="0" formula="zM--LK813k2IISJbLPVUNw" dim="InversedTime" quantityType="0" />
-                    <Parameter id="Yro0YOwqz0WUBdfRbWSodA" name="Distal radius" description="Distal radius of intestinal segment" persistable="0" isFixedValue="0" formula="R46ArBLQ1US2Gb1bCChBmA" dim="Length" quantityType="0" />
-                    <Parameter id="nJdopHZf1Uuo3w9jMDz1MQ" name="FillLevelFlag" description="Fill Level Flag" persistable="0" isFixedValue="0" formula="pBby0d8e50ijLxI1Zd-y8A" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="5ijilJBkUkKAB_gV8GUxCQ" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" persistable="0" isFixedValue="0" formula="R8YUpuD9WUq3gmHvTNnXvQ" dim="InversedTime" quantityType="0" />
-                    <Parameter id="jRtNElBDn0ClmPIHaozQoA" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" persistable="0" isFixedValue="0" formula="SdN69bnvNEKeuk8z2n3lGQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="ok25rhu4dkamF-n7TIaIlA" name="Length" description="Length" persistable="0" isFixedValue="0" formula="GC0lSgOyJUOIXmPp5q-wcg" dim="Length" quantityType="0" />
-                    <Parameter id="jdURp6zsBka5VDddQBSDkg" name="Liquid" description="Liquid" persistable="0" isFixedValue="0" formula="R6kHqMVgX0GtvICqeL6FFw" dim="Volume" quantityType="0" rHSFormula="DL_a0Dg0k0C5tFCQj7p5Xg" />
-                    <Parameter id="5UOwqwelcEa6P8y4v2VLbA" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" persistable="0" isFixedValue="0" formula="VgdcgTvFEE25D0o7rafJfg" dim="Rate" quantityType="0" />
-                    <Parameter id="0bkYclkbb0Gg7TQah2V7rw" name="Proximal radius" description="Proximal radius of intestinal segment" persistable="0" isFixedValue="0" formula="bOSpmtTi7k2o4j709TGn3A" dim="Length" quantityType="0" />
-                    <Parameter id="Qc_UL1uVz0qF6CJzfDPZ0A" name="Secretion of liquid" description="Rate of liquid inflow" persistable="0" isFixedValue="0" formula="piA8aElv4UiQSGajhmOVZg" dim="Flow (volume)" quantityType="0" />
-                    <Parameter id="377ySTVK1ESFzLekELNxPw" name="Thickness of gut wall" description="Thickness of Gut Wall" persistable="0" isFixedValue="0" formula="CrwFKdc0AkmmncutO67a1A" dim="Length" quantityType="0" />
-                    <Parameter id="d0FXvDkjaUikNdAOvPb_BQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="xhED215POEuWycLJEijJ4Q" dim="Volume" quantityType="0" />
-                    <Parameter id="b1ImzGxuoEWOlNTBWRW84A" name="Volume (gut wall)" description="Volume of the gut wall" persistable="0" isFixedValue="0" formula="1JjHOu_qXUCfLrDZjfqvTA" dim="Volume" quantityType="0" />
-                    <Parameter id="a4Hf2-mGhkeqrn4r1V9hIA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="owgI66XQcE2ClB4BHV50ew" dim="Volume" quantityType="0" />
-                    <Parameter id="q2SQ0wfkDkKuzcDzGUrEmg" name="Intestinal transit rate" description="Transit rate along intestinal segments" persistable="0" isFixedValue="0" formula="bHie-eF_VUer31KC01bvXg" dim="InversedTime" quantityType="0" />
-                    <Parameter id="RAEcGbe3n0SA1V-AzBrR4g" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="0ZEAtyCVGkyWTA0SNSylmw" dim="Length" quantityType="0" />
-                    <Parameter id="GIpToIBV2EmCQQeLbe1oBw" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="ZtO7r1x91UODkzmKNJocWw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="xdXqGp8G4kyzINZtuU-T8g" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="pi_w3M3p1EmFK27-gAz0ZA" dim="Length" quantityType="0" />
-                    <Parameter id="s1ufLsPIlkm7l1I7tAn_2Q" name="pH" description="pH" persistable="0" isFixedValue="0" formula="mRx0e3ShMk254Hc-npDIDQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="m4zGqSUYJk-p8k82-O-omg" name="Microvilli factor" description="Microvilli factor" persistable="0" isFixedValue="0" formula="4s1jeNhO60iYfiKGkSU9tw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="PEZPZuqxNk2aFNOcXYxdNA" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="gbpQmrCJsE-1kiATH6utsw" dim="Length" quantityType="0" />
-                    <Parameter id="Kvyg13KSokCQQQIhTXo-yA" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" persistable="0" isFixedValue="0" formula="q0qqHyqVkkKEZq0C6M9D5A" dim="Fraction" quantityType="0" />
-                    <Parameter id="OgKdx1Bo9EubGkIUIO_q1g" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" formula="7Y42NwJCrUeV0T-_hS-sBQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="EEZoHWT86EOEl0bjdUBaEw" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="cuxOGeOoCUanl17uoTmW5g" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="aPvAIadfDEmkpVLlvSW6DA" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" formula="MDzFEBDs_065rtIwIO81Vw" dim="Length" quantityType="0" />
-                    <Parameter id="YD3MJg2yUkWEJwaP5X31Mg" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." persistable="0" isFixedValue="0" formula="qhK8MUmNh0agzUEaNPrv-Q" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="5wQcSRCFCEKloOrJtb10wA" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" formula="x8cas679P0W4LmtWLV0XzA" dim="InversedLength" quantityType="0" />
-                    <Parameter id="K-P5bvu6R0yRPlsTMLyY4w" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." persistable="0" isFixedValue="0" formula="GR5WFYZ13kCedzvVG3d6NQ" dim="Length" quantityType="0" />
-                    <MoleculeAmount id="2jgxGdCNzUeUlFBm086prw" name="Drug" icon="Drug" persistable="0" isFixedValue="0" formula="QUY2EkrzE0-SmULHwUm9rg" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="KxHj7tFHSk2JPErI9bv1rw" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Parameter id="gP7zBl2wK0ahfMNJArmGYw" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" persistable="0" isFixedValue="0" formula="fBazVHP0M0uffy8bqBdZOw" dim="Amount" quantityType="0" rHSFormula="NFz4N9S-B0e-gl2hzy_IqA" />
-                        <Parameter id="aJkx7mPXkECkx2i6ECGKQg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="Lbw-p_T_s0maGbZbgr8n5g" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="o-REGdaSLEi0KU8s91-FcQ" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="OE4FfGUDBkma3R1ExgwFow" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="AqWaP4IDrEWRswNpcef2tA" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" persistable="0" isFixedValue="0" formula="RrG_-Fxb9EmjBf8-IF9PWA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="c8R2HGfShEa47wSz6o7Pzg" name="Solubility" description="Solubility" persistable="0" isFixedValue="0" formula="mjoRc5bGQ0uENr9Wir9H8g" dim="Concentration" quantityType="0" />
-                        <Parameter id="SVwiLkAswE-Eu_K5TTuGsg" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="t_mBMttbJEuFHQgp2BUFpQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="2jX5KeYBj0aQbs0GG2OWVA" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="SJ9zHWR740mvGPWKwQP8MQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="EvKFLP5xLEa-hB5caeDxHQ" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="mUXf-LjAB0aTLPr97gxjiA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="qEvnefkwVEeRzHjYko3ncg" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="GFQv4SJf4k6I1nYmNDdzVQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="oTVuFW9Gh0WeLkAcBwohSQ" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="c3qMqqyIaUugXK5m_x-G5Q" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="sQJ9d1ABukqj67dwUsLI2w" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="QV9HEyR3rUugj3TmlZ6OhQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="vv6h7G8oyUuU2nOSxKma7A" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="h-lBK2tLl0ioXtx3aFMmjQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="EYxUjPC6A02TWiJQfSjXvg" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="k_7HLzqXSE-b3tkBZFaZHQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="ThW3Bta1kUWz4aX06ZpYnA" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="kscELFafrEyaMjTPJb31FQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="Bq1vqa1AQkSga_A9CAhJ5Q" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="o2GjSzMBNUaKBfcG0xLp1g" dim="Dimensionless" quantityType="0" />
-                        <Observer id="xNMLIy2Qt0e4z8f4F7FE-A" name="Concentration in lumen" description="Concentration of the molecule in lumen" persistable="1" isFixedValue="0" formula="j43RhC6Wv0W0HJ9_uFMTPw" dim="MolarConcentration" quantityType="Drug, Observer" />
-                        <Observer id="eAZYM3Lh1UiMB4HAqm0Uyw" name="Fraction of oral drug mass absorbed into mucosa segment" description="Fraction of oral drug mass absorbed into mucosa segment" persistable="1" isFixedValue="0" formula="5nbLuxyKsUig2MN-jcY9IA" dim="Fraction" quantityType="Drug, Observer" />
-                      </Children>
-                    </MoleculeAmount>
-                    <MoleculeAmount id="eTo6rwhJjU6gUN8JmZEzvw" name="Cyp" icon="Enzyme" persistable="0" isFixedValue="0" formula="wb5yCXJZxUeVY_7iSBmoSg" dim="Amount" quantityType="Enzyme" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="mM1p471g40Gb-0bWcn723g" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" formula="WE7Y3nwHXUWe1iin8SJXXA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="_DQEeNUdIEqYioKbc4HoGw" name="Relative expression out." description="Relative Expression that will be used in the simulation" persistable="0" isFixedValue="0" formula="GtBZCb_uvUKgURPKDkyZKA" dim="Fraction" quantityType="0" />
-                        <Parameter id="QBQSKCpo0kOLolWaEr5lkQ" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" persistable="0" isFixedValue="0" formula="B5_VvOhHUkOrHzDEDs_ZTw" dim="Fraction" quantityType="0" />
-                        <Parameter id="Qptapij5GEamUuC_QUNMQg" name="Relative expression" description="Relative expression" persistable="0" isFixedValue="0" formula="cuzKHlsTM0SnthBZ0I4Hmw" dim="Fraction" quantityType="0" />
-                        <Parameter id="SQwF1n7iJ06yH0HzJ3i45g" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                      </Children>
-                    </MoleculeAmount>
-                    <MoleculeAmount id="M-FDbbW5b0q5c0gLxcl9Fg" name="Drug-Cyp Metabolite" persistable="0" isFixedValue="0" formula="nFWeZ5JTskOOQ41r4tOPTA" dim="Amount" quantityType="Metabolite" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="0e_DtBI_IEi4sUx_asHBlg" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Observer id="iWwRWmyafkOcf_js4NqLWg" name="Fraction of dose" description="Metabolized fraction of administered dose" persistable="1" isFixedValue="0" formula="aUoTQ3n3a0OShljd8bUj3w" dim="Fraction" quantityType="Metabolite, Observer" />
-                      </Children>
-                    </MoleculeAmount>
-                    <Reaction id="R-3f0flrkUu9hTwYXBWJNw" name="Cyp-ME" icon="Metabolism" mode="Logical" containerType="Other" dimension="Dimensionless" formula="NrKgrsKmwkiGET1q7OIPYg">
-                      <Educts>
-                        <ReactionPartner stoichiometricCoefficient="1" partner="2jgxGdCNzUeUlFBm086prw" />
-                      </Educts>
-                      <Products>
-                        <ReactionPartner stoichiometricCoefficient="1" partner="M-FDbbW5b0q5c0gLxcl9Fg" />
-                      </Products>
-                      <ModifierNames>
-                        <ModifierNamesChild>Cyp</ModifierNamesChild>
-                      </ModifierNames>
-                    </Reaction>
-                  </Children>
-                </Container>
-                <Container id="Zb000C93tkOQsbWGbFP-_w" name="Feces" description="Feces compartment used to collect the fraction excreted of the compound from the instestinal wall into the gut lumen." mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Feces" />
-                    <Tag value="Lumen" />
-                    <Tag value="LumenSegment" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="UzrCWxhJQkCkmJ8FWrLn3Q" name="Liquid" description="Liquid" persistable="0" isFixedValue="0" formula="EM-4W2yguUyQGEKHmQICbg" dim="Volume" quantityType="0" rHSFormula="21-WjSahnUuto28QobZ-iw" />
-                    <Parameter id="-z8b-6IeR0KPd_OC8qzCGg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="8jt-NGZqLkagLmixqXseZg" dim="Volume" quantityType="0" />
-                    <MoleculeAmount id="aSxEuZbc3kiOJhMGmIHJUQ" name="Drug" icon="Drug" persistable="0" isFixedValue="0" formula="TF9bNejYpEGJ9qiFq9bDCQ" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="M4yGsUiQPU6B2JMr0XMjFw" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Observer id="Y27uVTN56EGzPHLV01XSZA" name="Concentration in lumen" description="Concentration of the molecule in lumen" persistable="1" isFixedValue="0" formula="j43RhC6Wv0W0HJ9_uFMTPw" dim="MolarConcentration" quantityType="Drug, Observer" />
-                      </Children>
-                    </MoleculeAmount>
-                  </Children>
-                </Container>
-                <Container id="35VX_Ke3Ak2_sWxN-rQSTg" name="Drug" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Observer id="VwSJqM4NWkiQ-lCdr_N8Yw" name="Fraction dissolved" description="Dissolved fraction of all oral applications" persistable="1" isFixedValue="0" formula="UziCyN-lcUCjSXPZRH72mw" dim="Fraction" quantityType="Drug, Observer" />
-                    <Observer id="LRrp8UQuWUqcFGJb1TxPWw" name="Fraction of oral drug mass absorbed into mucosa" description="Fraction of oral drug mass absorbed into mucosa" persistable="1" isFixedValue="0" formula="C2geHtqTKUavWTs776zHig" dim="Fraction" quantityType="Drug, Observer" />
-                  </Children>
-                </Container>
-              </Children>
-            </Container>
-            <Container id="8NTwhMErsUy0k8diSjpQvw" name="Stomach" description="Stomach" icon="Stomach" mode="Logical" containerType="Organ">
-              <Tags>
-                <Tag value="Stomach" />
-                <Tag value="Portal Vein Supplying Organ" />
-                <Tag value="TissueOrgan" />
-              </Tags>
-              <Children>
-                <Parameter id="yG6t9e9jykKpO-1j-BI0Dg" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" formula="e00rJLV-2ESSluAEqpp3eg" dim="Volume" quantityType="0" />
-                <Parameter id="Edl1UvItZUioWbF4VdcdNQ" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" formula="FbGzbaLst0K5o2gc_gSjaQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="oSvMiZBGpka29fpO9lP9Dw" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" formula="mVEWvGqrgE-KcEv8JHNkQw" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="824P3eYA9EaUGQBvsRwdBQ" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" persistable="0" isFixedValue="0" formula="cgwwiOZXSk6Fbt3KVNscrA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="ELtTICboc02kD99q8VEUkQ" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" formula="rQNgT5I9w0CugJgtKeqn2g" dim="Density" quantityType="0" />
-                <Parameter id="xfDImfZ5BUCnsFi9GhX7Yw" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" formula="f-wDmu6wNE-m5XjCb_Y3jw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="O-o5ldVvzEOUu-ANwT3SQg" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" formula="6zJI7ULHVUOgKLMqOHulAg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="PEvB8gIzjEmr_JVOUYFAQw" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" formula="CLPNhoyXPkWkR2j_UBm6qA" dim="Nanolength" quantityType="0" />
-                <Parameter id="eaUp8gCmUU2PlvduUNn3rw" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" formula="imwJVN-VBUSxC94IE0mZlA" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="cTMUeIXoJUyJ2NQpEDUiPA" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" formula="VDU8z4p34ECFCacdS7qDAg" dim="Nanolength" quantityType="0" />
-                <Parameter id="r2WyeAyClEGS7KcFQ3bwTQ" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" formula="0sRtHg6_HUy5LQ-8seWdtQ" dim="HydraulicConductivity" quantityType="0" />
-                <Parameter id="kYOrhZIx-0qUjjG4YOCbzQ" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" formula="dtcV6e2fS0WayklyIEY95Q" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="yISU95Z2LUieopgWZd_1iA" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="hniY98-vfUOfCQroO5NuCw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="sON8Nl5g8EqHHZGR0VincA" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="1XGlse0CK0Km4fMBrDWv9w" dim="Dimensionless" quantityType="0" />
-                <Parameter id="unla_FfmfUWs7hFA_3w3pA" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" formula="M1ByMR4EZUGV-TT9w6h_LA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="AH_XsdfutkW_6gM0aTe_DQ" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="O4KWRMJ7H06YrmUdIZjWpQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="pQoZMhccZEG6A9jgznozFA" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="g2OHzjexH0yt6kgge7ytvg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="5YhlsjPQN0KofQd9EPN8AA" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="fB0V55O08Uusu7xh7F4IVg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="KOqnSjDJaE6y2L-mL9gcfg" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="zK4eXC5UMUCatGnii2GCjA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="fas-G9-xzku9VOQ1er6epg" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="7P1EeuRxXk-dOKjIps0bUQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="5EWEDr3af0O-q26N3U-c0w" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="B8kvIAFLwUm4NK7mJ_LP_A" dim="Dimensionless" quantityType="0" />
-                <Parameter id="czYR40f2hk-5ZvXes0ZNbQ" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="ADJY61BMZE-2PcCFqGs6Tg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="X4zQ6AUEA02vHy9-2x0yOA" name="Microsomal protein mass/g tissue" description="Microsomal protein content per gram tissue" persistable="0" isFixedValue="0" formula="_80C_z_aa0WJyP25x2n1Gw" dim="MassProteinPerTissue" quantityType="0" />
-                <Parameter id="rAT_cXgmZUusZi6mL1jXnQ" name="Number of cells/g tissue" description="Number of cells per gram tissue" persistable="0" isFixedValue="0" formula="ZkfY_ATnlUi258lm_bc02A" dim="CellQuantityPerTissue" quantityType="0" />
-                <Parameter id="QjeQq6n4Pka0dlnKpiW6lQ" name="Protein mass/g tissue" description="Total protein content per gram tissue" persistable="0" isFixedValue="0" formula="xVRMM8948UC38-JqDUPFJQ" dim="MassProteinPerTissue" quantityType="0" />
-                <Parameter id="HCs_w6_U80S-GODQWDOGuA" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" formula="gQDIQr_Tn0eCoYTHCG1YtA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="s7j8nDmj3UmFy6xXU15sfQ" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="RpowUvhVu0uuAracnwu_zA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="qIfdryhBdkuJ5I7e8n4Kgw" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="cDwATj0gCk-4dfBWHmI2qA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="5s02NruXDUWAQdcgu2YkWA" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="D8ZQ-sCBKkeAlFVBFeHSaA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="lWUIT4dJmkuLts-tTzEkjQ" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="Fp_00-2l2UKQM_rrNcsnNA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="HSlISoEkM0CtwY7ySXDgIA" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="0_5rJJFp1EOo-_bGmM-RbA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="DB4s22eeeEuY_XqPlqCvKA" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="Sx2FC30BRkG3-Vz37iPKaA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="eCDm3T5r7kmegz_DR-cf9A" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="YMXC09gphEeLaZd-efhtng" dim="Dimensionless" quantityType="0" />
-                <Parameter id="7Nc6VzMpDEyI098RckI-uA" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="D5Y_6ga7W0SSqMv-zR1FTw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="hbSD_70u_Uuxb8z6nwf9iA" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="0nub9dLS8UimtF3hczUK3g" dim="Dimensionless" quantityType="0" />
-                <Parameter id="GQW5e7b3eEu70MhduGf-yw" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="c5o-JB41hUm3647IbSuCIg" dim="Dimensionless" quantityType="0" />
-                <DistributedParameter id="m-FqdrHuoUqr9FRyzQjCxw" name="Volume" description="Volume of organ or compartment" persistable="1" isFixedValue="0" formula="rEmpLWl0MECiV-N90zAbgw" dim="Volume" quantityType="0" mode="Logical">
-                  <Children>
-                    <Parameter id="0v3n4irhy0G-v-n38dRkBg" name="Percentile" persistable="0" isFixedValue="0" formula="MSVOG6_76kC1DrmqyjhkMw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="wdWlFN7us0CA68vPfTkKqQ" name="Mean" persistable="0" isFixedValue="0" formula="2t1BWoHQ90mTkkFEGwpm1Q" dim="Volume" quantityType="0" />
-                    <Parameter id="vrOfiy0920eK6k5g2bBLrA" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" formula="SoUG1tY3n0-zplAE9-VBVA" dim="Volume" quantityType="0" />
-                  </Children>
-                </DistributedParameter>
-                <DistributedParameter id="Li0Y-wbiVUCQckg4l6wvfA" name="Specific blood flow rate" description="Blood flow rate normalized to the organ volume" persistable="1" isFixedValue="0" formula="dxCWQJPziEiF96h2fsTRkA" dim="Flow (volume) per organ weight" quantityType="0" mode="Logical">
-                  <Children>
-                    <Parameter id="LjkaQ1cVb06bXlalktN-7g" name="Percentile" persistable="0" isFixedValue="0" formula="pEIFHJCc80GwVc1VJ-Mh-g" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="lzm35mw4xU-SAzyBvbASOQ" name="Mean" persistable="0" isFixedValue="0" formula="lE7AX6LLQ06DIg4g9hgeGQ" dim="Flow (volume) per organ weight" quantityType="0" />
-                    <Parameter id="Pxfua_nbsEuFLrWLmyDW7w" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" formula="9xS9L28Ll0Sgu2I12LBoUw" dim="Flow (volume) per organ weight" quantityType="0" />
-                  </Children>
-                </DistributedParameter>
-                <Container id="j-2k7VES9ka5euMEPF9T8w" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Plasma" />
-                    <Tag value="Portal Vein Supplying Organ" />
-                    <Tag value="Stomach" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="-hPv0q_IukKlFwJxCO91nQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="owgI66XQcE2ClB4BHV50ew" dim="Volume" quantityType="0" />
-                    <Parameter id="F29tcNGN90mwgXNby_M-dw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="rbp4e7PXpUyuD1ZtA8Ocxw" dim="Volume" quantityType="0" />
-                    <MoleculeAmount id="kKt46BLgxk2cFdLr4ynp5g" name="Drug" icon="Drug" persistable="0" isFixedValue="0" formula="RSCVtJRhh0yEbXUMsRn_Jw" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1">
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-                        <Parameter id="j1YJ31nuZU-sHR5SsqxJTQ" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Parameter id="ryLALeU-SE2eD_EjKphSIg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="gyP-_TRrf0WLoWvyz7w-dw" dim="Dimensionless" quantityType="0" />
-                        <Observer id="9UxEFxq3W0WDB0Gw6G1k-Q" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Drug, Observer" />
-                      </Children>
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-                    <MoleculeAmount id="1F6y5jV4N0-apq5TFE4ydQ" name="Cyp" icon="Enzyme" persistable="0" isFixedValue="0" formula="wb5yCXJZxUeVY_7iSBmoSg" dim="Amount" quantityType="Enzyme" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="K_igYiJ77kCkm04bjq-Syw" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" formula="gcLOy2wWZUyEaYiTPSBfGw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="0UnAWTjRMkGH2RZtTt02Yw" name="Relative expression out." description="Relative Expression that will be used in the simulation" persistable="0" isFixedValue="0" formula="GtBZCb_uvUKgURPKDkyZKA" dim="Fraction" quantityType="0" />
-                        <Parameter id="k3akLK9xQEqAbIZ85VDl8A" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" persistable="0" isFixedValue="0" formula="Qv2OyMi-nU-kPqJ48WVuVw" dim="Fraction" quantityType="0" />
-                        <Parameter id="3elGBDODGE-kgFk1CuH7ww" name="Relative expression" description="Relative expression" persistable="0" isFixedValue="0" formula="iUzjEbj_NkSh4u8TNBhFgQ" dim="Fraction" quantityType="0" />
-                        <Parameter id="yNkAvldJ-E-IkWFPyQWdRQ" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Observer id="efFAI3YWyk6b5v5E8H7PYQ" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Enzyme, Observer" />
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-                    <MoleculeAmount id="QNkSom5u7Ue7i_nstCk-lw" name="Drug-Cyp Metabolite" persistable="0" isFixedValue="0" formula="pPXy8xwpDE2HMwrljDZGwQ" dim="Amount" quantityType="Metabolite" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="BfZi2jieMkiLY12U6r5XUA" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Observer id="DzynMD7qkEiNJk5QF3Ua4Q" name="Fraction of dose" description="Metabolized fraction of administered dose" persistable="1" isFixedValue="0" formula="aUoTQ3n3a0OShljd8bUj3w" dim="Fraction" quantityType="Metabolite, Observer" />
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-                      <Educts>
-                        <ReactionPartner stoichiometricCoefficient="1" partner="kKt46BLgxk2cFdLr4ynp5g" />
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-                        <ReactionPartner stoichiometricCoefficient="1" partner="QNkSom5u7Ue7i_nstCk-lw" />
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-                      <ModifierNames>
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-                <Container id="bHoVLvrvKUOmXQKR7iPaJg" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="BloodCells" />
-                    <Tag value="Portal Vein Supplying Organ" />
-                    <Tag value="Stomach" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="JDxnVmv7zUGPn6OXp7xBJw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="owgI66XQcE2ClB4BHV50ew" dim="Volume" quantityType="0" />
-                    <Parameter id="Em9GrzRAZkaQy6ZzDuCXng" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="tFZiRJ-Sv0qf0gsV7ycmYw" dim="Volume" quantityType="0" />
-                    <MoleculeAmount id="B5S9SFj4f02rIOWx3cl5jA" name="Drug" icon="Drug" persistable="0" isFixedValue="0" formula="3S_AzLShiEOFxeeLNHQABw" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="KGkIce8saEq0rYLHHXsjwg" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Parameter id="CvQVrvD06061oS_vMhWReA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="B7GvWAjGjE-90_Xdbd8_LA" dim="Dimensionless" quantityType="0" />
-                        <Observer id="Vx65QKU0dk24xACWCcO-5w" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Drug, Observer" />
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-                    <MoleculeAmount id="CZDJyxrGrEisXk4hURxAsg" name="Cyp" icon="Enzyme" persistable="0" isFixedValue="0" formula="wb5yCXJZxUeVY_7iSBmoSg" dim="Amount" quantityType="Enzyme" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="kSLlJwgsYUKdLZGQe9wYAg" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" formula="Mq0atFzd50ys_I6txMVhiA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="5Gr9WQgSCESNfJEOGlbVCg" name="Relative expression out." description="Relative Expression that will be used in the simulation" persistable="0" isFixedValue="0" formula="GtBZCb_uvUKgURPKDkyZKA" dim="Fraction" quantityType="0" />
-                        <Parameter id="AKon39T7MUSGYo5pvaEQWQ" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" persistable="0" isFixedValue="0" formula="FTxLv_b4CkKigLwWdcA4xg" dim="Fraction" quantityType="0" />
-                        <Parameter id="qO91mPeLC0-PZ55q4W6nwA" name="Relative expression" description="Relative expression" persistable="0" isFixedValue="0" formula="_J3C13ewoUatoCS2w-zxeg" dim="Fraction" quantityType="0" />
-                        <Parameter id="wCmC25pV4EylcB0pJYkf0w" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
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-                        <Parameter id="WMwFBIc8_06f_sTi3Cqpzg" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
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-                      <Educts>
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-                      <ModifierNames>
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-                <Container id="dsM-eBic2EiX35Jw6MAWJQ" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Interstitial" />
-                    <Tag value="Portal Vein Supplying Organ" />
-                    <Tag value="Stomach" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="rA7F10d-80WOEUQjeTMfeQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="owgI66XQcE2ClB4BHV50ew" dim="Volume" quantityType="0" />
-                    <Parameter id="gTjdA8YgMkWyCkpI_Smt4A" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="4VSppd3W3E6-12kllCJ0Mg" dim="Volume" quantityType="0" />
-                    <Parameter id="y6Ode0WLp0CWSf0_aANpfw" name="pH" description="pH" persistable="0" isFixedValue="0" formula="tKjHIxsi60KoHEPhXQBZrw" dim="Dimensionless" quantityType="0" />
-                    <MoleculeAmount id="yw8Zl0mYSk-wXOPqkEExpA" name="Drug" icon="Drug" persistable="0" isFixedValue="0" formula="5L0EH1qob0y366oPMRwcYA" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1">
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-                        <Parameter id="Fp5Q9zirQUip0GAAtPkPTg" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Parameter id="hFyq8FLr8Uu-rYphfpfBzQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="9S3oWEfWFkK-stI3jeNPhA" dim="Dimensionless" quantityType="0" />
-                        <Observer id="aCJXGqLCVkekWDTdH0-hig" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Drug, Observer" />
-                      </Children>
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-                <Container id="4zjuWX0sR0eCa5Fxtr1w2g" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Intracellular" />
-                    <Tag value="Portal Vein Supplying Organ" />
-                    <Tag value="Stomach" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="6XfOIV8Kp0eIaDuLI21hkA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="M9arQg_qfEGMA7JdlSXkFA" dim="Volume" quantityType="0" />
-                    <Parameter id="5IUGgLBvDUqfy2KNGfo3bA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="3l84whkuX0S7xUUHglUQpg" dim="Volume" quantityType="0" />
-                    <Parameter id="Fo-F1zHFWEi4bAQN1ZSqRA" name="pH" description="pH" persistable="0" isFixedValue="0" formula="G76cc_qbPUCqdq8Oo6XH8w" dim="Dimensionless" quantityType="0" />
-                    <MoleculeAmount id="XEssCflDyEOpsFc7tNK4OQ" name="Drug" icon="Drug" persistable="0" isFixedValue="0" formula="Xc22AwXvpEe8WxK3E55PyQ" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="qPznwNKKXk-blZ147cUI2w" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Parameter id="OadFhRoB6EyHKQjiHChDrQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="4D6Fj7tVyk6RldjIfOkTQA" dim="Dimensionless" quantityType="0" />
-                        <Observer id="eh-pa222_UqUqO1sVCTmYA" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Drug, Observer" />
-                      </Children>
-                    </MoleculeAmount>
-                    <MoleculeAmount id="FDpHc513pE29IVoARPBbZw" name="Cyp" icon="Enzyme" persistable="0" isFixedValue="0" formula="wb5yCXJZxUeVY_7iSBmoSg" dim="Amount" quantityType="Enzyme" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="U40inwXDcUiGge5fB7Nf3w" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" formula="U4Ijupf8oUuGX1Nc7twN5Q" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="h190rxzu5EChFOuoxJIoMQ" name="Relative expression out." description="Relative Expression that will be used in the simulation" persistable="0" isFixedValue="0" formula="GtBZCb_uvUKgURPKDkyZKA" dim="Fraction" quantityType="0" />
-                        <Parameter id="6Jm9UuiWzU6lvFyS7eIQgA" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" persistable="0" isFixedValue="0" formula="kl-p-EGhlkCBhiSF3YIyow" dim="Fraction" quantityType="0" />
-                        <Parameter id="J3ld4zQyxUSM2jpEZzOcAw" name="Relative expression" description="Relative expression" persistable="0" isFixedValue="0" formula="mEz7S2R6eEyZnkIml6RuiA" dim="Fraction" quantityType="0" />
-                        <Parameter id="vqRDtEpGbEaEfKHhpPNXQg" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Observer id="GQhUXQAhJkqnVuoLkLfSnA" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Enzyme, Observer" />
-                      </Children>
-                    </MoleculeAmount>
-                    <MoleculeAmount id="4sM4DIZhw0q__LGLnakMvg" name="Drug-Cyp Metabolite" persistable="0" isFixedValue="0" formula="WK_T5L5N00qApTWlP9Sv0w" dim="Amount" quantityType="Metabolite" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="V2S69y1KaEy-JcY94WiTvg" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Observer id="do8JsDHSXEq3t1SG2P0yag" name="Fraction of dose" description="Metabolized fraction of administered dose" persistable="1" isFixedValue="0" formula="aUoTQ3n3a0OShljd8bUj3w" dim="Fraction" quantityType="Metabolite, Observer" />
-                      </Children>
-                    </MoleculeAmount>
-                    <Reaction id="8vcL0k3Y_kalG94Psm0SnA" name="Cyp-ME" icon="Metabolism" mode="Logical" containerType="Other" dimension="Dimensionless" formula="NrKgrsKmwkiGET1q7OIPYg">
-                      <Educts>
-                        <ReactionPartner stoichiometricCoefficient="1" partner="XEssCflDyEOpsFc7tNK4OQ" />
-                      </Educts>
-                      <Products>
-                        <ReactionPartner stoichiometricCoefficient="1" partner="4sM4DIZhw0q__LGLnakMvg" />
-                      </Products>
-                      <ModifierNames>
-                        <ModifierNamesChild>Cyp</ModifierNamesChild>
-                      </ModifierNames>
-                    </Reaction>
-                  </Children>
-                </Container>
-                <Container id="1ddfViFWBU6kodpAmg53yw" name="Drug" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Observer id="H3BnhQrah0CSiNgtmIob8Q" name="Interstitial Unbound" description="Interstitial Unbound" persistable="1" isFixedValue="0" formula="sb2EI4hIhEWxy5ZYMY2QFw" dim="MolarConcentration" quantityType="Drug, Observer" />
-                    <Observer id="MpteMdYdYE2jSULnu3vqWg" name="Intracellular Unbound" description="Intracellular Unbound" persistable="1" isFixedValue="0" formula="F5kFVlFTnEmJToE6fKssfA" dim="MolarConcentration" quantityType="Drug, Observer" />
-                    <Observer id="xGhy7gsNGkK-GEkLzCrN4w" name="Tissue" description="Tissue" persistable="1" isFixedValue="0" formula="wztK_G9P_0mMbsEE9LSVMw" dim="MolarConcentration" quantityType="Drug, Observer" />
-                  </Children>
-                </Container>
-              </Children>
-            </Container>
-            <Container id="QidVhpTRsEmqQHWvltQc0w" name="SmallIntestine" description="SmallIntestine" icon="SmallIntestine" mode="Logical" containerType="Organ">
-              <Tags>
-                <Tag value="SmallIntestine" />
-                <Tag value="Portal Vein Supplying Organ" />
-                <Tag value="TissueOrgan" />
-              </Tags>
-              <Children>
-                <Parameter id="2VdM6aWgwkuaoS5Uoo92LA" name="Small intestinal transit time factor" description="Small intestinal transit time factor" persistable="0" isFixedValue="0" formula="HL49MmuXoESojKXaiICOdg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="-lzndjPjyUujCcVNNtOI2g" name="Colon_Arrival_Time_Slope" description="Supporting parameter for calculation of colon arrival time" persistable="0" isFixedValue="0" formula="d49YTmAar06hL8MVS-wFbg" dim="Time" quantityType="0" />
-                <Parameter id="CAyhZpBotUON_DekEDQJwA" name="Colon_Arrival_Time_Intercept" description="Supporting parameter for calculation of colon arrival time" persistable="0" isFixedValue="0" formula="ZGZzSbq7SU-oaS5R5aex1A" dim="Time" quantityType="0" />
-                <Parameter id="sXtJLz1tvEClxJmiVu8dZg" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" formula="cgcMA5AO8kWf0avXSL_A3A" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="YRRq6gXo9E2Z6Yg7ZB90Nw" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" formula="jm2dd-SYQEyLUGjR4FMe-g" dim="Volume" quantityType="0" />
-                <Parameter id="WgMTGkv2C0azr5Vv15Uu6A" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" formula="LUmSCkAESEmWgO2hulog1Q" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="_axebcquLUmcOTucmoI2oA" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" formula="FbGzbaLst0K5o2gc_gSjaQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="FcGn7XF8FUOx88nkooLawQ" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" formula="mVEWvGqrgE-KcEv8JHNkQw" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="I657Kysgr0ywdOT4bIf2_w" name="Volume (mucosa)" description="Volume of mucosa" persistable="0" isFixedValue="0" formula="O2kOff3kEk6QmuxXWJaOwg" dim="Volume" quantityType="0" />
-                <Parameter id="Pyhc3CSpYU-CdnBaQQw2Cw" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" persistable="0" isFixedValue="0" formula="fK_bws8JWU6C-dVGOntqWA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="t-sujXf8QUOD-6jTq39ylQ" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" formula="fWWKRSGXQ0uwhD6ub_jQtQ" dim="Density" quantityType="0" />
-                <Parameter id="DpIho1QSWE2tLOi6LqSeQw" name="Colon_Arrival_Time_Intercept_a0" description="Supporting parameter for calculation of colon arrival time" persistable="0" isFixedValue="0" formula="oUiTgACq50WAMnI4uKuyyQ" dim="Time" quantityType="0" />
-                <Parameter id="8Oo8COoFf0eOjDQ7iS__1g" name="Colon arrival time" description="Colon arrival time" persistable="0" isFixedValue="0" formula="yHwQ_gk5WEGB4gltO-9n6w" dim="Time" quantityType="0" />
-                <Parameter id="hFWNKcMXU0e7jALNSri-Vg" name="Mucosa blood flow fraction" description="Blood fraction which goes to mucosa" persistable="0" isFixedValue="0" formula="m0qWGg3pr0mHGG2W85j9XA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="2FBXA7Ew3k-6Qzg1Y1Pw-Q" name="Colon_Arrival_Time_Slope_a2" description="Supporting parameter for calculation of colon arrival time" persistable="0" isFixedValue="0" formula="mO5SWxDZ4kG-aF75MEH9dA" dim="InversedTime" quantityType="0" />
-                <Parameter id="otG6OjmzrEyjUReuV9WGXA" name="Colon_Arrival_Time_Slope_a1" description="Supporting parameter for calculation of colon arrival time" persistable="0" isFixedValue="0" formula="xncg2rE_a0yHEnzMZHUBBQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="e0eoFVMNK0yWsZT_Kxf8UA" name="Colon_Arrival_Time_Slope_a0" description="Supporting parameter for calculation of colon arrival time" persistable="0" isFixedValue="0" formula="fnp6g1okUEiAZPyzc2TQvA" dim="Time" quantityType="0" />
-                <Parameter id="Prmb4r56kUqz-RxeTTzoRg" name="Colon_Arrival_Time_Intercept_a1" description="Supporting parameter for calculation of colon arrival time" persistable="0" isFixedValue="0" formula="0Nxx25D2wE-CgGqVJrT4yw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="Ps2ZWiNmwUS8Wx5_0uF-Iw" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" formula="p8aIamuq90ajabw3aoe4Cw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="g7YWM0Dr-0SVKx0go1yEfg" name="Lymph flow rate (incl. mucosa)" description="Lymph flow rate (incl. mucosa)" persistable="0" isFixedValue="0" formula="4wiJmAIKIE6NSyfM3xYGWg" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="cKrgHM4Ctk6R3sR0675UXg" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" formula="RKBel-s0MkueE9HiGpUU0A" dim="Dimensionless" quantityType="0" />
-                <Parameter id="j2l7j56jCkW8iAcgdOiWHA" name="Fluid recirculation flow rate (incl. mucosa)" description="Fluid recirculation flow rate between plasma and interstitial space (incl. mucosa)" persistable="0" isFixedValue="0" formula="sdJzzzRNk0OhYyuEpwxy-g" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="KbORqPdioEG5tg1hb6pMcw" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" formula="azjxqSXAUkaR_PDOu6vxTQ" dim="HydraulicConductivity" quantityType="0" />
-                <Parameter id="yVposhfAaU6L6gj9KFpINg" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" formula="NjZY2MNuJ0mWoubprzfeSQ" dim="Nanolength" quantityType="0" />
-                <Parameter id="RMACUapl6UGA_VM9QlxZaQ" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" formula="oYqAxiHbqk23UMIZ716aDg" dim="Nanolength" quantityType="0" />
-                <Parameter id="JrzTU3UaX0KsBil2O8plOw" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="AK6s0nVSVk6DzM4Q0_307Q" dim="Dimensionless" quantityType="0" />
-                <Parameter id="5w8IxNTy7USjoOBMgaGmGQ" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="7xpScne680qYR4z3EjUTBw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="wNaZBgq3lku5P1vd4gyMZQ" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" formula="tkHb9ygrp0-EvCZKPHX4eg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="q56NKRNDWkGH59GYt8j3PQ" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="Q-QzR69KT0ycKHkTkb1K9w" dim="Dimensionless" quantityType="0" />
-                <Parameter id="uuYsavEiDEGvzbxpn9DwYw" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="G7Mv3NumlkSpBfgPgJUoaQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="XuqSvlnTikKrbX3ma-7YSA" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="4H-c_lS9D0yhPx7HU1mvAg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="ea4_7iFLw0CgK2IlP-UwEA" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="Sp_Zg_gfb0m3hA06qyP2_A" dim="Dimensionless" quantityType="0" />
-                <Parameter id="tllctc757k2q0y-SVm6M7Q" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="72yMKzXjXEOV4izIiENO7w" dim="Dimensionless" quantityType="0" />
-                <Parameter id="RMMgcy0KUUicJc-kq9wxWw" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="UbdPmpV6gUabP4HnTLHnVQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="fF1hbD4eoEaKBg5YawL2XA" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="O1IIguWVsUOSpR9IMvOOag" dim="Dimensionless" quantityType="0" />
-                <Parameter id="jLz4YE2HqEu-6fW1ZfLJAg" name="Microsomal protein mass/g tissue" description="Microsomal protein content per gram tissue" persistable="0" isFixedValue="0" formula="whAikSGmFE-gDdZ80BMzcQ" dim="MassProteinPerTissue" quantityType="0" />
-                <Parameter id="0KnrMcwpSUi1ldt6VLLh0g" name="Number of cells/g tissue" description="Number of cells per gram tissue" persistable="0" isFixedValue="0" formula="U53SQeejs0aIBq7l2Q3AMQ" dim="CellQuantityPerTissue" quantityType="0" />
-                <Parameter id="TrIIhvM82kepcQhP62nToA" name="Protein mass/g tissue" description="Total protein content per gram tissue" persistable="0" isFixedValue="0" formula="_UrsGqAL0Eq1iDhD7Lu5iQ" dim="MassProteinPerTissue" quantityType="0" />
-                <Parameter id="tbqoW33GDkeL7vh4_14WqA" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" formula="5fyL9UkFyUSBiKWNiFNwdQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="tc_YZRj9Y0OjoR--cGEpkQ" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="Qbz8JNRFe0CcdqIyjnQHkg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="iQ6xV7VF302ZoOpqC5BOXg" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="bhFXqS4RlkKFvJCpFkMRVA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="S4oPqCUeRU2fhBerLcjMXQ" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="jbNCJII2tUOqdcc-H0T6jw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="YQBaF3V8WEGPc6N-lXRaYg" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="rF5zdGHPlEicTQmoOBoFgQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="4MrR_6AgAEiiB9yJnDqK9A" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="3au1TWYfVkSdvDuteJukDQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="O02EJlkJEUedoi8zGd80KQ" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="QXWZ9f-bwkGEe9v40gbKBQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="weScT6_lC0iVk7A-DzOySg" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="rsmfYrsHi0uYM7yL1ciOCQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="0U2daYBD402jSrkuZ40fug" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="mlkDrUrnj0qsFsXpo975Sw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="3SBg8thLSE6tJHyProeOCA" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="3w1NLeG4JkmCY1ztpV5zQw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="7gbnIrRZ1EON5KNL00r41A" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="K43TfyJpYk2QrCAX5GB7Yg" dim="Dimensionless" quantityType="0" />
-                <DistributedParameter id="fvoZdCMGu0OQzKbMrr5Tlw" name="Volume" description="Volume of organ or compartment" persistable="1" isFixedValue="0" formula="twCtJC942ECcwHfoBlggyA" dim="Volume" quantityType="0" mode="Logical">
-                  <Children>
-                    <Parameter id="HWZR2XkOg06YsJjTHAEklg" name="Percentile" persistable="0" isFixedValue="0" formula="Z-zm6ehA00ujq6Uc7BDhqw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="MqM4WYL5BEWDiE-K1LA_1A" name="Mean" persistable="0" isFixedValue="0" formula="mqaerRWkpUKoZWBOPgxKtQ" dim="Volume" quantityType="0" />
-                    <Parameter id="o63rXsuvVESAvGQrFC-Cuw" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" formula="VKvQPpOnl0iZ_sU0A5axXQ" dim="Volume" quantityType="0" />
-                  </Children>
-                </DistributedParameter>
-                <DistributedParameter id="21hXMUyb-UWl2mY9c9CGUQ" name="Specific blood flow rate" description="Blood flow rate normalized to the organ volume" persistable="1" isFixedValue="0" formula="juWDPQR6VUGogsQU-JQy1A" dim="Flow (volume) per organ weight" quantityType="0" mode="Logical">
-                  <Children>
-                    <Parameter id="rytPN7sJfEeHSc5CVkyP0g" name="Percentile" persistable="0" isFixedValue="0" formula="mneZ7P5QbkClBQJCI_RqZA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="XQTmEopTSU2ftM48_uwHlA" name="Mean" persistable="0" isFixedValue="0" formula="OXHKRrupb0KBDZFWVbRGAA" dim="Flow (volume) per organ weight" quantityType="0" />
-                    <Parameter id="oJNWG_LL_kKV-De4fk_MnA" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" formula="-GXwkPWyjUiLTRoDKclGww" dim="Flow (volume) per organ weight" quantityType="0" />
-                  </Children>
-                </DistributedParameter>
-                <Container id="_l2zQZC3T0igTnQWgWvr8Q" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Plasma" />
-                    <Tag value="Portal Vein Supplying Organ" />
-                    <Tag value="SmallIntestine" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="LtzCqKwmK0SsQSiPlTLQvQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="owgI66XQcE2ClB4BHV50ew" dim="Volume" quantityType="0" />
-                    <Parameter id="KQhR6g1RpkunGgdb-F2Rpg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="yOdsFdfvgU-9h2LWnUPLRw" dim="Volume" quantityType="0" />
-                    <MoleculeAmount id="_992ECbn50GcVDRjD1WdnQ" name="Drug" icon="Drug" persistable="0" isFixedValue="0" formula="latbDbTQyEKYQKrZpIB0qQ" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="2umXjbNu1UycVwq-P-fvfw" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Parameter id="iMcmM2tye0uHOjQkMud6vw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="eVCzuSJ090eVrYZHH9qhXQ" dim="Dimensionless" quantityType="0" />
-                        <Observer id="emVFeVaH0EKBVYicob5MWw" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Drug, Observer" />
-                      </Children>
-                    </MoleculeAmount>
-                    <MoleculeAmount id="QkiJwMBgsU-Lszm5q5njQg" name="Cyp" icon="Enzyme" persistable="0" isFixedValue="0" formula="wb5yCXJZxUeVY_7iSBmoSg" dim="Amount" quantityType="Enzyme" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="CNQWe5FoCE-fiOxEhFufBw" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" formula="aURkllfmw0q_w6P3qmptJQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="YbDO_WTJAkum_ZZU5VL_3Q" name="Relative expression out." description="Relative Expression that will be used in the simulation" persistable="0" isFixedValue="0" formula="GtBZCb_uvUKgURPKDkyZKA" dim="Fraction" quantityType="0" />
-                        <Parameter id="2vqsKSEMJUi3L6owL-9QQw" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" persistable="0" isFixedValue="0" formula="Qv2OyMi-nU-kPqJ48WVuVw" dim="Fraction" quantityType="0" />
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-                        <Parameter id="Xv9iGfMUmUW_nW-P06LO_g" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="EiFnSSiAdEyA4AKI5rM0XQ" dim="Volume" quantityType="0" />
-                        <Parameter id="0rM9ai5tQEKfcEBWeUbs0w" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" formula="6e9LHlTFJkG-PMFyieazhw" dim="Flow (volume)" quantityType="0" />
-                        <Parameter id="q1hL0DCjXEq4H1N3PtNSxQ" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" formula="hB48fjDKB0aPhnPyDobY9g" dim="Flow (volume)" quantityType="0" />
-                        <Parameter id="oXIlgBG-EkytRy9JNxvvxQ" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" formula="TwvXN-oFKUuusOE5NrCoGg" dim="Volume" quantityType="0" />
-                        <Parameter id="WJocHNWLmkCOHnmqwYkj_A" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" formula="PSbm5ReMbUKRj9xRJC3ccA" dim="Flow (volume)" quantityType="0" />
-                        <Parameter id="RYsh8z8iOkKbSGBYl71zhw" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" formula="FbGzbaLst0K5o2gc_gSjaQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="Xg2D0khFSk-lfu3Za5Sgmg" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" formula="lHChGcq4S02bPsMd2kYR9Q" dim="Density" quantityType="0" />
-                        <Parameter id="5CocuiGcl0uXTV2GzN5xwA" name="Fraction mucosa" description="Mucosal fraction of regional intestinal tissue mass" persistable="0" isFixedValue="0" formula="s7bkCDXgfEO0gbMyshQy5Q" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="lumnPksH506TVUweuZnSRA" name="Fraction of regional blood flow rate" description="Regional blood flow fraction supplying the mucosal tissue of the segment" persistable="0" isFixedValue="0" formula="kRph10tyIESLDiQlEf3AaA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="rNiyJzX7qU2OUdAmEHy-Vg" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" formula="KyRuwkPOUUyVD0wZ7t7eNw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="flpLdvOAjUq1X3GR-iJ-wA" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" formula="ttl7296xyk-HngChX3RRTg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="ll77SpE4zkuH8usaqX_MEw" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" formula="NphA4aSgcE2lpfC4RfAa6w" dim="HydraulicConductivity" quantityType="0" />
-                        <Parameter id="o3zuUUzfQEGJQmFYwm2kdA" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" formula="RgnRjE1M70yItsRvctOgYQ" dim="Nanolength" quantityType="0" />
-                        <Parameter id="VjyNDqP7_0ipoSb1ByS-eg" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" formula="lbrISwDddUCZw3Y8hiKz9A" dim="Nanolength" quantityType="0" />
-                        <Parameter id="8nrnNDvHl02U873b1aXuYA" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="7KIKOe6K_UuCvE8VxAHAEQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="lkJ_JSApYUSFCti6HHc0ww" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="9Xb23_3grUm0BrIAoe6FkQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="C2_s5rdS_ECtrjPM-hwTZg" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" formula="czCRvuDM4UyGW__Baffv6g" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="-tnrItDN-kuu8OH_3Kit8A" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="H5xtFHLnHU6vwuug2pv0pQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="Put20U2ZR0Kd104sEM11wg" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="oUL8N3lD2keXjw6wg--9vw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="RSOfzB75WEiIjIno76tOWg" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="8lPQXMzRZ0uLAodmdBpLHA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="MPZLaDPWc0iEN2mn6WvrRw" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="c8mZMXm8BE6KgAAG5MVS8g" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="UX-NA1u2AkW8EvTyNbqMCw" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="kHz0FEr3yU-xToxEdE9kIA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="l-JQQBqpMEWNyeuVIgFawQ" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="-WP9beKDBEe24CqnNStzgA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="5dhOse3TWkOt8MGYWu8pFQ" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="SPkmjmD1O02PsiJCFthLbg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="bA6dIoFv10-O2Q2L1wmUOw" name="Microsomal protein mass/g tissue" description="Microsomal protein content per gram tissue" persistable="0" isFixedValue="0" formula="98RPF6ZKOE21oR4A9WoDUA" dim="MassProteinPerTissue" quantityType="0" />
-                        <Parameter id="xsOTCotqwk2Vg-EkWE9mXQ" name="Number of cells/g tissue" description="Number of cells per gram tissue" persistable="0" isFixedValue="0" formula="qDiYJSkH8kGHLB0246wD6w" dim="CellQuantityPerTissue" quantityType="0" />
-                        <Parameter id="jMaNXy3tfECg3Guqavv7NA" name="Protein mass/g tissue" description="Total protein content per gram tissue" persistable="0" isFixedValue="0" formula="te-HOvYDiEWfTyvqHNTvjA" dim="MassProteinPerTissue" quantityType="0" />
-                        <Parameter id="ncweeq76CEidh1hyKj6Nrg" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" formula="Ks_iBRIxiEySPhr1RWt1_Q" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="ys-52qktr0eSfDvxGc76fQ" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="6Ax0XePlNUm62FJ_1z-TUw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="ClHWWofpOUGcLYfF1b88Fw" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="c5gZ-o8vbEmIeTy3JMDfOg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="TQOI0ELA6US2jbs47BdKrw" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="pLwJXGxKdUSELcdUpKqO_Q" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="Zwagm0Wej0Gm8xPXNTquEQ" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="Wn8XN7-47UuFekj4e6fHlg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="W8JqGoG1U0aZIVFRo2ZI3A" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="ZK6-prm6zUuSoIYSU9MTPg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="OE3kD-Jgmk2aPuQIvZU4BQ" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="iLoM11oEkkegm1W4bNxQKg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="sACgVPKJvUS8GBEaJhfXkQ" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="fWK7D-fnL06A2Ke7hBub-A" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="Hxw_RN2aoEON-lL-EjXXTA" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="2A9A9uD6AEuBe47hoKfJzw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="lfBDUGkDS0aP_12QEmbYbg" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="CQgvo4JENkWQA5LtBZXBdA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="VxjLhs9oRkKKP9E2DZ0FEA" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="OpSST1A2E0WxDr4qr_Yh_g" dim="Dimensionless" quantityType="0" />
-                        <Container id="qpsNmcf0yECPn6bPfvoWbA" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Plasma" />
-                            <Tag value="Duodenum" />
-                            <Tag value="Mucosa" />
-                            <Tag value="SmallIntestineSegment" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="8Ol7srcbTkGTI1H5QwF9tA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="owgI66XQcE2ClB4BHV50ew" dim="Volume" quantityType="0" />
-                            <Parameter id="KYhqTegBdkefmtHnIrhKMg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="rbp4e7PXpUyuD1ZtA8Ocxw" dim="Volume" quantityType="0" />
-                            <MoleculeAmount id="NuXtwyVbBESYGyhe3qyqWQ" name="Drug" icon="Drug" persistable="0" isFixedValue="0" formula="MMYs02zE7E-xhqg_51EOyA" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="VqWnbFOA4ESxDNaXMd-1sg" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Parameter id="FymqErQdB0eGxBbM6csJNQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="5Tl8T8SnTk6OA9sosdq2mw" dim="Dimensionless" quantityType="0" />
-                                <Observer id="Jit6mescDkuCASFR6NRj7A" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Drug, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                            <MoleculeAmount id="hyX4yCQ8d0ifnCaZE8xHbQ" name="Cyp" icon="Enzyme" persistable="0" isFixedValue="0" formula="wb5yCXJZxUeVY_7iSBmoSg" dim="Amount" quantityType="Enzyme" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="GjnduAw5d02yE4eG_5Oliw" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" formula="2uaxYEyajkS2UKBFXM79FQ" dim="Dimensionless" quantityType="0" />
-                                <Parameter id="X8E6anwtUEmCDlMsv58J3g" name="Relative expression out." description="Relative Expression that will be used in the simulation" persistable="0" isFixedValue="0" formula="GtBZCb_uvUKgURPKDkyZKA" dim="Fraction" quantityType="0" />
-                                <Parameter id="VpPWl2jwB0yErR2oOyBPEw" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" persistable="0" isFixedValue="0" formula="Qv2OyMi-nU-kPqJ48WVuVw" dim="Fraction" quantityType="0" />
-                                <Parameter id="--Zl-CH260KYh4s4qrHBQw" name="Relative expression" description="Relative expression" persistable="0" isFixedValue="0" formula="iUzjEbj_NkSh4u8TNBhFgQ" dim="Fraction" quantityType="0" />
-                                <Parameter id="iMiCLkbYikiP6daHJ0Km7g" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Observer id="sOOs7t6bGEuMwI_w-TKabw" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Enzyme, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                            <MoleculeAmount id="5p5ZBriZl0qK1rSZWCPFFw" name="Drug-Cyp Metabolite" persistable="0" isFixedValue="0" formula="1jOfrGcoHUi70hM5oQ0-WA" dim="Amount" quantityType="Metabolite" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="whUHlipfnE2rLxzIJ2X3Tw" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Observer id="JOFfn7MK6UO6cKza6ZlGKw" name="Fraction of dose" description="Metabolized fraction of administered dose" persistable="1" isFixedValue="0" formula="aUoTQ3n3a0OShljd8bUj3w" dim="Fraction" quantityType="Metabolite, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                            <Reaction id="E3UgBXHz0kumVKVG80DW_Q" name="Cyp-ME" icon="Metabolism" mode="Logical" containerType="Other" dimension="Dimensionless" formula="NrKgrsKmwkiGET1q7OIPYg">
-                              <Educts>
-                                <ReactionPartner stoichiometricCoefficient="1" partner="NuXtwyVbBESYGyhe3qyqWQ" />
-                              </Educts>
-                              <Products>
-                                <ReactionPartner stoichiometricCoefficient="1" partner="5p5ZBriZl0qK1rSZWCPFFw" />
-                              </Products>
-                              <ModifierNames>
-                                <ModifierNamesChild>Cyp</ModifierNamesChild>
-                              </ModifierNames>
-                            </Reaction>
-                          </Children>
-                        </Container>
-                        <Container id="G67GNfr5nUejQBYiVNI7Gw" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="BloodCells" />
-                            <Tag value="Duodenum" />
-                            <Tag value="Mucosa" />
-                            <Tag value="SmallIntestineSegment" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="VWuWZnkguUCuGLQtJatiWA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="owgI66XQcE2ClB4BHV50ew" dim="Volume" quantityType="0" />
-                            <Parameter id="ag-jQLU7xU-9tSuMCy9VGg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="tFZiRJ-Sv0qf0gsV7ycmYw" dim="Volume" quantityType="0" />
-                            <MoleculeAmount id="I-wcOfVzhUubhukFSm8Z-A" name="Drug" icon="Drug" persistable="0" isFixedValue="0" formula="f06caPOIL0CvkxYWsmBT6Q" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="hrdc4FxIUUycR2cD7e4eRw" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Parameter id="UG4q2r0YfkK-5oP9VMve2A" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="VI9G2ylwGk2mfwNzJ-Wadg" dim="Dimensionless" quantityType="0" />
-                                <Observer id="DOWmZEgTZ0Gk7f1fx6GUkQ" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Drug, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                            <MoleculeAmount id="nSYt4CygF0i2vzvsU7T0ng" name="Cyp" icon="Enzyme" persistable="0" isFixedValue="0" formula="wb5yCXJZxUeVY_7iSBmoSg" dim="Amount" quantityType="Enzyme" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="uM730Q3WgkyDL_4wYvyw4Q" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" formula="xuU_nngank2N-uRGi-9nqQ" dim="Dimensionless" quantityType="0" />
-                                <Parameter id="AlKof-AVTEOV33x490o2Qg" name="Relative expression out." description="Relative Expression that will be used in the simulation" persistable="0" isFixedValue="0" formula="GtBZCb_uvUKgURPKDkyZKA" dim="Fraction" quantityType="0" />
-                                <Parameter id="FgfCLQ5WSEuLeDwvMxNzWg" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" persistable="0" isFixedValue="0" formula="FTxLv_b4CkKigLwWdcA4xg" dim="Fraction" quantityType="0" />
-                                <Parameter id="PQGt_uUi-0-sXd7HZLaHkw" name="Relative expression" description="Relative expression" persistable="0" isFixedValue="0" formula="_J3C13ewoUatoCS2w-zxeg" dim="Fraction" quantityType="0" />
-                                <Parameter id="w_8JvgZeVEGskqbx4itlzQ" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Observer id="UPI4Upm_M0m81wHLGOjwvQ" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Enzyme, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                            <MoleculeAmount id="sBl-6wHAlE2N_mWQ6Ed0gQ" name="Drug-Cyp Metabolite" persistable="0" isFixedValue="0" formula="pZddoxQ0z0GTzmCYIshNlA" dim="Amount" quantityType="Metabolite" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="UIuzwfzf20SClEpJ7GsTQw" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Observer id="LVNbxWXB_0Ga3DXcbBOXfg" name="Fraction of dose" description="Metabolized fraction of administered dose" persistable="1" isFixedValue="0" formula="aUoTQ3n3a0OShljd8bUj3w" dim="Fraction" quantityType="Metabolite, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                            <Reaction id="LJlfh2jxvEGUaJ85eOeDKg" name="Cyp-ME" icon="Metabolism" mode="Logical" containerType="Other" dimension="Dimensionless" formula="NrKgrsKmwkiGET1q7OIPYg">
-                              <Educts>
-                                <ReactionPartner stoichiometricCoefficient="1" partner="I-wcOfVzhUubhukFSm8Z-A" />
-                              </Educts>
-                              <Products>
-                                <ReactionPartner stoichiometricCoefficient="1" partner="sBl-6wHAlE2N_mWQ6Ed0gQ" />
-                              </Products>
-                              <ModifierNames>
-                                <ModifierNamesChild>Cyp</ModifierNamesChild>
-                              </ModifierNames>
-                            </Reaction>
-                          </Children>
-                        </Container>
-                        <Container id="ywuD3Bwyok28OM2s_VCT0w" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Interstitial" />
-                            <Tag value="Duodenum" />
-                            <Tag value="Mucosa" />
-                            <Tag value="SmallIntestineSegment" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="FAWFJo9gAEyMgKeCZgL1jA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="owgI66XQcE2ClB4BHV50ew" dim="Volume" quantityType="0" />
-                            <Parameter id="B3Z1r3f9L0K-ygGmSFl6mg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="4VSppd3W3E6-12kllCJ0Mg" dim="Volume" quantityType="0" />
-                            <Parameter id="kDlhnW2CREOgwvFeCqoMWA" name="pH" description="pH" persistable="0" isFixedValue="0" formula="tKjHIxsi60KoHEPhXQBZrw" dim="Dimensionless" quantityType="0" />
-                            <MoleculeAmount id="I9BWMF8_3kSBQIDxrfcggQ" name="Drug" icon="Drug" persistable="0" isFixedValue="0" formula="FP8zgCANIkKMVN5xHwIfRg" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="YU5HgBcgoUCkLf70AI8D2g" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Parameter id="dDqDb2niY0-F4QvkmCRBWg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="vwT_mzCP5kW0aqs2ebGfHg" dim="Dimensionless" quantityType="0" />
-                                <Observer id="8HQBvCvav0-5S1rNQeVl7g" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Drug, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                          </Children>
-                        </Container>
-                        <Container id="yo07wiCfk0SB0-zR6Q-smQ" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Intracellular" />
-                            <Tag value="Duodenum" />
-                            <Tag value="IntestinalSecretionSource" />
-                            <Tag value="Mucosa" />
-                            <Tag value="SmallIntestineSegment" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="XzxtC39QF0642xSHLUSWJQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="M9arQg_qfEGMA7JdlSXkFA" dim="Volume" quantityType="0" />
-                            <Parameter id="WdNidwbJR0K6mDtFLR7a2w" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="3l84whkuX0S7xUUHglUQpg" dim="Volume" quantityType="0" />
-                            <Parameter id="ctm3gU55l0KHC6sC5SxFxQ" name="pH" description="pH" persistable="0" isFixedValue="0" formula="AnrczBmXFESZdeAqZSQcuA" dim="Dimensionless" quantityType="0" />
-                            <MoleculeAmount id="lzS0IgRFyUe26aoyeKkgTw" name="Drug" icon="Drug" persistable="0" isFixedValue="0" formula="pS4mdQrh5EiznqajYzpaxQ" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="rHSiPyFJ_EGFQ3V0pYHu5w" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Parameter id="Yx9QbC3EKU2_mU6LHQh1ZA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="sgZICXhCdkWTgz0-1jdHSw" dim="Dimensionless" quantityType="0" />
-                                <Observer id="1hbP-4FTukSIdbJhyT2ELw" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Drug, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                            <MoleculeAmount id="JhxP3O5cwEWCRoZ6SvmX8Q" name="Cyp" icon="Enzyme" persistable="0" isFixedValue="0" formula="wb5yCXJZxUeVY_7iSBmoSg" dim="Amount" quantityType="Enzyme" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="mmjPhIuRSkSM39mqIutivA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" formula="6JMhhJX0A0mymLK5dOG2HA" dim="Dimensionless" quantityType="0" />
-                                <Parameter id="B1HAdSEu50aL53qpFWkmMA" name="Relative expression out." description="Relative Expression that will be used in the simulation" persistable="0" isFixedValue="0" formula="GtBZCb_uvUKgURPKDkyZKA" dim="Fraction" quantityType="0" />
-                                <Parameter id="qYpDFDJajU6pOc9y_uOO8Q" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" persistable="0" isFixedValue="0" formula="-gAn2g9WBkCM0DEM93H1pA" dim="Fraction" quantityType="0" />
-                                <Parameter id="tbz2N3GnsE-MZuZv6BMFZA" name="Relative expression" description="Relative expression" persistable="0" isFixedValue="0" formula="fze_d6wHV0qtE3Mkj2y_tg" dim="Fraction" quantityType="0" />
-                                <Parameter id="7wenYAbAQUa3S21e-ndkCQ" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Observer id="NhHDLr9uH0O0Bb9mYGMGzQ" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Enzyme, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                            <MoleculeAmount id="ykb3bUnFi0aD2xqa3D08Jg" name="Drug-Cyp Metabolite" persistable="0" isFixedValue="0" formula="z-eeZZScy02MjO4T92A54g" dim="Amount" quantityType="Metabolite" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="FgIYW1parUakcgZ27L7nMw" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Observer id="u06UMZu8WE660X-HuMmccA" name="Fraction of dose" description="Metabolized fraction of administered dose" persistable="1" isFixedValue="0" formula="aUoTQ3n3a0OShljd8bUj3w" dim="Fraction" quantityType="Metabolite, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                            <Reaction id="Hb1b14cEtEK8sJcq9EsFCg" name="Cyp-ME" icon="Metabolism" mode="Logical" containerType="Other" dimension="Dimensionless" formula="NrKgrsKmwkiGET1q7OIPYg">
-                              <Educts>
-                                <ReactionPartner stoichiometricCoefficient="1" partner="lzS0IgRFyUe26aoyeKkgTw" />
-                              </Educts>
-                              <Products>
-                                <ReactionPartner stoichiometricCoefficient="1" partner="ykb3bUnFi0aD2xqa3D08Jg" />
-                              </Products>
-                              <ModifierNames>
-                                <ModifierNamesChild>Cyp</ModifierNamesChild>
-                              </ModifierNames>
-                            </Reaction>
-                          </Children>
-                        </Container>
-                      </Children>
-                    </Container>
-                    <Container id="dlBMXlfEt0-ckHvOMXKMxQ" name="UpperJejunum" description="Upper Jejunum" icon="UpperJejunum" mode="Logical" containerType="Compartment">
-                      <Tags>
-                        <Tag value="UpperJejunum" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="PVxOVk7B7kGk9vV8xnmcZQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="cbsbywMo7E2aqhL83RyD3w" dim="Volume" quantityType="0" />
-                        <Parameter id="wh2xD05_VUyJkZpj3A7zFA" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" formula="hB48fjDKB0aPhnPyDobY9g" dim="Flow (volume)" quantityType="0" />
-                        <Parameter id="cdBiwkrbyE-qtfdAZ_BMJg" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" formula="6e9LHlTFJkG-PMFyieazhw" dim="Flow (volume)" quantityType="0" />
-                        <Parameter id="-fVSw_7ARkqiIC9g0Lb9zQ" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" formula="5B4kb9vXCU2mc8TeR9g7FQ" dim="Volume" quantityType="0" />
-                        <Parameter id="8YlT0vJy_k6ZPEfvGuJb5w" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" formula="PSbm5ReMbUKRj9xRJC3ccA" dim="Flow (volume)" quantityType="0" />
-                        <Parameter id="9oEpsmH8pkqoMnZjaJ-a3w" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" formula="FbGzbaLst0K5o2gc_gSjaQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="qfns_QFeOkOlNaL2llOyYw" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" formula="LYRBTU1OakufzOFWY75VuA" dim="Density" quantityType="0" />
-                        <Parameter id="sQ3IV5b9Q0m1VHlr3X8gIQ" name="Fraction of regional blood flow rate" description="Regional blood flow fraction supplying the mucosal tissue of the segment" persistable="0" isFixedValue="0" formula="hvx9rPFL5Uif4ky0HerQAg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="T-i-7PGa006o2-SdSi8HDg" name="Fraction mucosa" description="Mucosal fraction of regional intestinal tissue mass" persistable="0" isFixedValue="0" formula="az3fD22r1kefHJsJaw5QVA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="ijYvYZ8TW0SmVEQ9VR8D0Q" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" formula="i9s6hX6hmE2c2SocBXZDrg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="osKQC487Tk24QMh0BnfnUg" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" formula="L6atI78FqUS8ub7tc0L0Rw" dim="Nanolength" quantityType="0" />
-                        <Parameter id="waVSMi4NT06Iy6HAjctPJQ" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" formula="EW-mNezaiUubO-zEO9K7Og" dim="Nanolength" quantityType="0" />
-                        <Parameter id="47qQypK9G0GX8uHAsP-Pvg" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" formula="VEzF9JeQXEGtXjBcb9FiSQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="VX9GLzMEfU6gq2BKjLTaAw" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" formula="H5rtS8OJRESxhAGhvLI--A" dim="HydraulicConductivity" quantityType="0" />
-                        <Parameter id="M-3B59-b0EORmbTWqGcI1w" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="9Lre8QH_KkK0EecFmIc4Sw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="7WuFd1d6HkGVcJ8TxR2xbw" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="1SmzI6W7W0mIlv_y-v_rZw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="Bsqq4QX38Eub5SUux2-jQw" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" formula="VQCqH0hqhUCZrWUHlDoIqA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="4zhtXoxtP06foy78zPtKpw" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="U5W7WmFnBE6WaUBOv0DU6A" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="jkfuT9KLrkOKZ3uJaZuDlg" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="hlteLcrGt0um3K_UxyPwqg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="Pj_BkGqwjEiwIU5MR1wogQ" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="JZokcylfCE2tXQZB8JQLAw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="FtGpWZIISEy8PQT6PsK17g" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="saeai24hVEeRvedAg1Jweg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="ZUCuY2YyF02hc6vVTFo1Gg" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="2b9m3RvkZU-9Y-wvcVa9IA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="YqmyvV2FX0mOnBKQl7GAdg" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="MJGh3RgGgEayA2Caa4QEQg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="yDanvC7OnES_XiGWVrjAPw" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="BVkTKbZt60KSHhQBSlTbgA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="SrWNYIyCLUS5RsdGOikqEw" name="Microsomal protein mass/g tissue" description="Microsomal protein content per gram tissue" persistable="0" isFixedValue="0" formula="AxyPSD5QkEOkUhbHA8g5mA" dim="MassProteinPerTissue" quantityType="0" />
-                        <Parameter id="f-wcOl8C1k6LR-bReUaPSA" name="Number of cells/g tissue" description="Number of cells per gram tissue" persistable="0" isFixedValue="0" formula="tXH8asZe9kSaWClUij-SFA" dim="CellQuantityPerTissue" quantityType="0" />
-                        <Parameter id="ndjlIqfkPkiuFa74cjlXpg" name="Protein mass/g tissue" description="Total protein content per gram tissue" persistable="0" isFixedValue="0" formula="-snuFDuhuUiHMo-57l1aRw" dim="MassProteinPerTissue" quantityType="0" />
-                        <Parameter id="wWmuXrCBokSwkX0CHuUgFQ" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" formula="pz4JIgQUsEmEgJotDbAY1A" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="JeZe4lFKgE-aVxlvmJ6jhg" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="igjdm1y2l0aV57wmHXuccA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="xYq0f3RnY021HM0mFH6VCw" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="cXniNoWqR0i1PcoOj2RbEA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="xRO_Rizg6UCQQOe3MQywxA" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="GFsmxMsFbU-09u-md5ppbA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="KTdbOwKrs0qxTv855__dxQ" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="FqxwF8wcFEetJgUU2EktAg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="0WpyRB11GkWqA230m_p6gw" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="zWd6p6ohc0uVRnPGR7bFxg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="ZN-RPVoS4UypgVOhdKTdRQ" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="y4OEilp4r0mGl84SVs4SXQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="H5xmvcXySUG3I1-kz34kAA" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="FvycGg_LP0yyOcmsODtCQw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="zrA-YCcmf0u9BUpdJEr2HA" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="Kg-cF1TTQUyp2cf1uq_Skw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="6v9Rng_hQ0Ox-UriHr2stg" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="9aZs4ZJJcE6u-vCz4T1unA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="4w4j-wkndEOnfo_0xgMOMA" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="HeFC5xUmDEeyCtNpbFg-mw" dim="Dimensionless" quantityType="0" />
-                        <Container id="qeqwoTSkakOVMFqQIp36Rw" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Plasma" />
-                            <Tag value="Mucosa" />
-                            <Tag value="SmallIntestineSegment" />
-                            <Tag value="UpperJejunum" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="i3Ac19I_vk-2tv5SMmq0Rg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="owgI66XQcE2ClB4BHV50ew" dim="Volume" quantityType="0" />
-                            <Parameter id="m37T64U7zkKwv8fZnG2vZA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="rbp4e7PXpUyuD1ZtA8Ocxw" dim="Volume" quantityType="0" />
-                            <MoleculeAmount id="Cyoj-iIBBUK7nqW_avA9uw" name="Drug" icon="Drug" persistable="0" isFixedValue="0" formula="ku8pX1dDsEK2ydRbdTzw0Q" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="5DMnZoMh4ESEriRryxPgbg" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Parameter id="zRD-nKMzekC_ubbd4l10vA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="YaQg66OGf0KIH0f7ifHu1A" dim="Dimensionless" quantityType="0" />
-                                <Observer id="zU2AJME8tU6AGSbeuT5yjw" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Drug, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                            <MoleculeAmount id="IfKCleXnsEOmg7kxmtkz-A" name="Cyp" icon="Enzyme" persistable="0" isFixedValue="0" formula="wb5yCXJZxUeVY_7iSBmoSg" dim="Amount" quantityType="Enzyme" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="pqIoBtsiH0yGVm1EtMoJyQ" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" formula="Oye_hb26lEGI4ZEYs59fvw" dim="Dimensionless" quantityType="0" />
-                                <Parameter id="luoqLH31nU2K40NFkNPh8Q" name="Relative expression out." description="Relative Expression that will be used in the simulation" persistable="0" isFixedValue="0" formula="GtBZCb_uvUKgURPKDkyZKA" dim="Fraction" quantityType="0" />
-                                <Parameter id="Vr1PvVbv0kS1aU_WnI175w" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" persistable="0" isFixedValue="0" formula="Qv2OyMi-nU-kPqJ48WVuVw" dim="Fraction" quantityType="0" />
-                                <Parameter id="i330fnpMC0-v1jwa_8lxfg" name="Relative expression" description="Relative expression" persistable="0" isFixedValue="0" formula="iUzjEbj_NkSh4u8TNBhFgQ" dim="Fraction" quantityType="0" />
-                                <Parameter id="nzAby1rWeUqdI65nUUaEhA" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Observer id="58AHYT3e5UyId8olluoFMQ" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Enzyme, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                            <MoleculeAmount id="eaXIbXQrm0KQSpwnhhWodQ" name="Drug-Cyp Metabolite" persistable="0" isFixedValue="0" formula="3wUYfhWRfUijVelUxR5ttA" dim="Amount" quantityType="Metabolite" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="zJIX1A1t60iH5M0G3uzfig" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Observer id="s23BJ3PKYkqcCnokxRGAkA" name="Fraction of dose" description="Metabolized fraction of administered dose" persistable="1" isFixedValue="0" formula="aUoTQ3n3a0OShljd8bUj3w" dim="Fraction" quantityType="Metabolite, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                            <Reaction id="SjVgBHj7mEq9TAzmjKXfhQ" name="Cyp-ME" icon="Metabolism" mode="Logical" containerType="Other" dimension="Dimensionless" formula="NrKgrsKmwkiGET1q7OIPYg">
-                              <Educts>
-                                <ReactionPartner stoichiometricCoefficient="1" partner="Cyoj-iIBBUK7nqW_avA9uw" />
-                              </Educts>
-                              <Products>
-                                <ReactionPartner stoichiometricCoefficient="1" partner="eaXIbXQrm0KQSpwnhhWodQ" />
-                              </Products>
-                              <ModifierNames>
-                                <ModifierNamesChild>Cyp</ModifierNamesChild>
-                              </ModifierNames>
-                            </Reaction>
-                          </Children>
-                        </Container>
-                        <Container id="bkf1EKQC6UWHf1_K1uz-Hg" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="BloodCells" />
-                            <Tag value="Mucosa" />
-                            <Tag value="SmallIntestineSegment" />
-                            <Tag value="UpperJejunum" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="IIEYy8qfQUueQXRd2Z_9Fw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="owgI66XQcE2ClB4BHV50ew" dim="Volume" quantityType="0" />
-                            <Parameter id="Ve2J2Cac_kqOOqSM2yiR5A" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="tFZiRJ-Sv0qf0gsV7ycmYw" dim="Volume" quantityType="0" />
-                            <MoleculeAmount id="9xjcN-quk0yrAPxO3xJMjA" name="Drug" icon="Drug" persistable="0" isFixedValue="0" formula="qfRjrQdnFUutEiuRliqw0w" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="RHvJS5ZF8E-etiBbbx0IlQ" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Parameter id="1uDDsQcX9ECkUNrCVPxU9w" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="DUev837v-0ehi8UNSBb_sw" dim="Dimensionless" quantityType="0" />
-                                <Observer id="GV-sxfpPmkS1r84_UqmWxw" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Drug, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                            <MoleculeAmount id="wx4MtLBpSkO6GZkOxs105A" name="Cyp" icon="Enzyme" persistable="0" isFixedValue="0" formula="wb5yCXJZxUeVY_7iSBmoSg" dim="Amount" quantityType="Enzyme" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="bE2A7Y6nO0C-douGywgOeQ" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" formula="1ykqCYJmCkuOff3HFICctw" dim="Dimensionless" quantityType="0" />
-                                <Parameter id="EG9PXCyt_UasYiNINp2Zow" name="Relative expression out." description="Relative Expression that will be used in the simulation" persistable="0" isFixedValue="0" formula="GtBZCb_uvUKgURPKDkyZKA" dim="Fraction" quantityType="0" />
-                                <Parameter id="_a4L6MMk-0m5sQOY87gVbA" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" persistable="0" isFixedValue="0" formula="FTxLv_b4CkKigLwWdcA4xg" dim="Fraction" quantityType="0" />
-                                <Parameter id="eeXDxwGdK0qLWu9WX6Eb0g" name="Relative expression" description="Relative expression" persistable="0" isFixedValue="0" formula="_J3C13ewoUatoCS2w-zxeg" dim="Fraction" quantityType="0" />
-                                <Parameter id="YsN7E1WuLECLq3EQ2Yi-AQ" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Observer id="Dh7d9X-D1UOmnE8cFFp_yw" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Enzyme, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                            <MoleculeAmount id="xgzG4kajyEynRGaVdrI9kg" name="Drug-Cyp Metabolite" persistable="0" isFixedValue="0" formula="HtMYH6Gk10KbCq1Sa0tB7g" dim="Amount" quantityType="Metabolite" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="2snf82lK4E2_AshlZwGcvg" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Observer id="FkQnxyWBGE2CCuUJ_gVpDg" name="Fraction of dose" description="Metabolized fraction of administered dose" persistable="1" isFixedValue="0" formula="aUoTQ3n3a0OShljd8bUj3w" dim="Fraction" quantityType="Metabolite, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                            <Reaction id="28DjicTuvUCsyq-FBcJV6Q" name="Cyp-ME" icon="Metabolism" mode="Logical" containerType="Other" dimension="Dimensionless" formula="NrKgrsKmwkiGET1q7OIPYg">
-                              <Educts>
-                                <ReactionPartner stoichiometricCoefficient="1" partner="9xjcN-quk0yrAPxO3xJMjA" />
-                              </Educts>
-                              <Products>
-                                <ReactionPartner stoichiometricCoefficient="1" partner="xgzG4kajyEynRGaVdrI9kg" />
-                              </Products>
-                              <ModifierNames>
-                                <ModifierNamesChild>Cyp</ModifierNamesChild>
-                              </ModifierNames>
-                            </Reaction>
-                          </Children>
-                        </Container>
-                        <Container id="THYGK8yE7UOOTBWK-3FzrA" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Interstitial" />
-                            <Tag value="Mucosa" />
-                            <Tag value="SmallIntestineSegment" />
-                            <Tag value="UpperJejunum" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="bMRx5vEn7kKI6DcPr8G53A" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="owgI66XQcE2ClB4BHV50ew" dim="Volume" quantityType="0" />
-                            <Parameter id="VE96Iy_bHUeRfHRv5NY_fw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="4VSppd3W3E6-12kllCJ0Mg" dim="Volume" quantityType="0" />
-                            <Parameter id="P96uRsW-Fk-dOaBg7kWJQQ" name="pH" description="pH" persistable="0" isFixedValue="0" formula="tKjHIxsi60KoHEPhXQBZrw" dim="Dimensionless" quantityType="0" />
-                            <MoleculeAmount id="zTsutIMy7kiNK_k750RykQ" name="Drug" icon="Drug" persistable="0" isFixedValue="0" formula="8qeSQZOF-UGmqa8M1Gs1ng" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="FNeGaV6W4EKAwH9nyVlqVA" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Parameter id="6bWGcpIWr0Gof-lKtX5dWw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="uhVEiYfQ50a8OFSDJ7F1HA" dim="Dimensionless" quantityType="0" />
-                                <Observer id="ipPvI5jAYkm7CI4ZZOOtTQ" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Drug, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                          </Children>
-                        </Container>
-                        <Container id="N3VDr-XRDkSr4mlVC2UkHQ" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Intracellular" />
-                            <Tag value="IntestinalSecretionSource" />
-                            <Tag value="Mucosa" />
-                            <Tag value="SmallIntestineSegment" />
-                            <Tag value="UpperJejunum" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="AQ4PhViDdEa7rwY7_Qmbew" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="M9arQg_qfEGMA7JdlSXkFA" dim="Volume" quantityType="0" />
-                            <Parameter id="0CzODlm96kWc4T4tEDqOdQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="3l84whkuX0S7xUUHglUQpg" dim="Volume" quantityType="0" />
-                            <Parameter id="pbg877IdKk6vJWKI2RlUwQ" name="pH" description="pH" persistable="0" isFixedValue="0" formula="Bbsku2BhCkSq5WfFzXvvBw" dim="Dimensionless" quantityType="0" />
-                            <MoleculeAmount id="PHa0MNb1DUaXgdsbKCSSmQ" name="Drug" icon="Drug" persistable="0" isFixedValue="0" formula="6rDIDWfWY0O9vB0rQsNw_A" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="fwimPk1ukU-5g4WMp7ihFg" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Parameter id="HL-rC79quU67hxabm7qiaA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="YvikgOXajkGHOjYnlJ4e0g" dim="Dimensionless" quantityType="0" />
-                                <Observer id="7jHWUo5cH0CuIOMKxZaiNg" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Drug, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                            <MoleculeAmount id="cH5W5zBp4UaGu-9DxMfBBA" name="Cyp" icon="Enzyme" persistable="0" isFixedValue="0" formula="wb5yCXJZxUeVY_7iSBmoSg" dim="Amount" quantityType="Enzyme" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="H7PT7956lk6eWsSZiuD_ig" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" formula="hh7rEvvmY0iWQsh4Pa2guA" dim="Dimensionless" quantityType="0" />
-                                <Parameter id="bVdykkN8MkClybB5t1qfSA" name="Relative expression out." description="Relative Expression that will be used in the simulation" persistable="0" isFixedValue="0" formula="GtBZCb_uvUKgURPKDkyZKA" dim="Fraction" quantityType="0" />
-                                <Parameter id="6q2EhE5mbEOqBf_htaSzNQ" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" persistable="0" isFixedValue="0" formula="qnqSdqjbWEqpqALKRlYljQ" dim="Fraction" quantityType="0" />
-                                <Parameter id="9eslKIcQME2kGpvbAqo_OA" name="Relative expression" description="Relative expression" persistable="0" isFixedValue="0" formula="EAGVN0rohkKS2i07cGhNAw" dim="Fraction" quantityType="0" />
-                                <Parameter id="m1_yPSt7V0qGtPqG9Z1HOQ" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Observer id="2XSvm4eFMUOLjdnGDLFpCg" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Enzyme, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                            <MoleculeAmount id="RnsuiPYT9kW1pVJGctMS5Q" name="Drug-Cyp Metabolite" persistable="0" isFixedValue="0" formula="wleoF1rjaESMiExKOBynrA" dim="Amount" quantityType="Metabolite" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="Y_e-aE9w00-fJEBQzO-Kpg" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Observer id="pFRAX6wc1EOVde9bdSlxcA" name="Fraction of dose" description="Metabolized fraction of administered dose" persistable="1" isFixedValue="0" formula="aUoTQ3n3a0OShljd8bUj3w" dim="Fraction" quantityType="Metabolite, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                            <Reaction id="Lsw8Ay-GtECU5q_ozg8jfg" name="Cyp-ME" icon="Metabolism" mode="Logical" containerType="Other" dimension="Dimensionless" formula="NrKgrsKmwkiGET1q7OIPYg">
-                              <Educts>
-                                <ReactionPartner stoichiometricCoefficient="1" partner="PHa0MNb1DUaXgdsbKCSSmQ" />
-                              </Educts>
-                              <Products>
-                                <ReactionPartner stoichiometricCoefficient="1" partner="RnsuiPYT9kW1pVJGctMS5Q" />
-                              </Products>
-                              <ModifierNames>
-                                <ModifierNamesChild>Cyp</ModifierNamesChild>
-                              </ModifierNames>
-                            </Reaction>
-                          </Children>
-                        </Container>
-                      </Children>
-                    </Container>
-                    <Container id="aiSV1r4C6UyVv-VFnKQbsw" name="LowerJejunum" description="Lower Jejunum" icon="LowerJejunum" mode="Logical" containerType="Compartment">
-                      <Tags>
-                        <Tag value="LowerJejunum" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="zaO3cWlOX0qYkxfqckFsTA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="Ly8Wta6Y_kS1GW0s0ttEiw" dim="Volume" quantityType="0" />
-                        <Parameter id="REtOaK9ig0KPE07CGAStAg" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" formula="sPycL8rhI0KVxZREPfNaDw" dim="Volume" quantityType="0" />
-                        <Parameter id="VfWZa9MCtU2C8BO_aWtcpw" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" formula="6e9LHlTFJkG-PMFyieazhw" dim="Flow (volume)" quantityType="0" />
-                        <Parameter id="eOwgEtQ1DECPelLgekF-YA" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" formula="hB48fjDKB0aPhnPyDobY9g" dim="Flow (volume)" quantityType="0" />
-                        <Parameter id="qDTbW0GAaUKki_cfgQxJhQ" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" formula="PSbm5ReMbUKRj9xRJC3ccA" dim="Flow (volume)" quantityType="0" />
-                        <Parameter id="cccwmFly7UOMd83gn1ikug" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" formula="FbGzbaLst0K5o2gc_gSjaQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="JkiIIwKB-E6QLoyLCXAO8g" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" formula="W9vRMgLfx0ON7wn0zJEp0Q" dim="Density" quantityType="0" />
-                        <Parameter id="E7CnVPvRLki1juiGe9f7Nw" name="Fraction of regional blood flow rate" description="Regional blood flow fraction supplying the mucosal tissue of the segment" persistable="0" isFixedValue="0" formula="eAXueAKS8kuPvIY3f81MBw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="9XXbnlSi8Ui9NW1QwsUnDA" name="Fraction mucosa" description="Mucosal fraction of regional intestinal tissue mass" persistable="0" isFixedValue="0" formula="TaY2yIfL20KPsZTTavi13w" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="83Y5rWjJj0KylKDWBCgEiQ" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" formula="lFfyuv_ND0i8xVGIqZkkCg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="44qpLsk6rUa0CBRyq3J8lQ" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" formula="9Hqud_rRLU-rsE5UEEiPHw" dim="Nanolength" quantityType="0" />
-                        <Parameter id="jY8dXK4xFUiXnPe24is4Eg" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" formula="fauZSzK5K0-1Ni3j6o21Cg" dim="Nanolength" quantityType="0" />
-                        <Parameter id="pN92q5XRd0yiZBirLpuWZQ" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" formula="mpRxElyS1UWhJgvUp8VCQg" dim="HydraulicConductivity" quantityType="0" />
-                        <Parameter id="KgcqBMfevEe6VcsMfLMv2g" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" formula="3rb7WkyPf0KcSq612bSsNQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="W2HZgXQfPkGnOGMABIo7Tw" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="T4z9dFFFrUekvyck2W78Bg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="YGYf8mkPp0iWv25avig95w" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="MYVYqcIhw0qM-oYa_k6sqg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="2mw8HVy46Uajy78oKHcOHA" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" formula="HMV79z9yXES5hpjJP-46bw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="-dcUjwHTQ0KjmBZgUCog5A" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="eUXkVBzwuUubs9ffkA9r6w" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="51BUSeu6ZUmuLKvxnDgU6g" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="O7mweq7RO0-iRnQ7P05arg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="fa6eN8Q6C0-uyvmoYckRQg" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="qUB9dJmHdkCMD97xzrND4A" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="ECyyF6wQpk-f_FRF4ohIuw" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="qh-Ra2Oq5kq8gWm-xbM5og" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="Q69QGecA-kyYtKkB4m68Dg" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="S5ZjAXcTDUmx9DjBSXhwmA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="nkfmr8qxR06ga7mcPixzRw" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="7ERwrXUAkk-47_rfGyFbQQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="DJzCtaGoFk2bbavJdtmKQw" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="HSeuUlyKiUWCs6v93GCppQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="wcH07IU4EUOi2vIxVjoyuQ" name="Microsomal protein mass/g tissue" description="Microsomal protein content per gram tissue" persistable="0" isFixedValue="0" formula="vYjyoLG32k61933uXM3Z_g" dim="MassProteinPerTissue" quantityType="0" />
-                        <Parameter id="UH3-Whv-jEuFUp0MdyIWxA" name="Number of cells/g tissue" description="Number of cells per gram tissue" persistable="0" isFixedValue="0" formula="SHsGrxPV40iJzIm6uFL_xw" dim="CellQuantityPerTissue" quantityType="0" />
-                        <Parameter id="v2aF-lnKRUyvUemg1-TfVg" name="Protein mass/g tissue" description="Total protein content per gram tissue" persistable="0" isFixedValue="0" formula="Eu3-e-HB0EatIZC0rL_FHg" dim="MassProteinPerTissue" quantityType="0" />
-                        <Parameter id="HZFFmtc7PEKTe0X26_ft-A" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" formula="gSOZnzgaQUWihAaeFG5asQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="q91oUZ-Y-k6J0wgCAw99Tg" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="stPtnue3nUKDNVeslZL6DQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="_yLwLp_mpkm0G-XOYF6xwA" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="6Ypjh-XTFEuzH1uZnl_UaQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="iuHi_v29Rk-J6op0_AsY9w" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="bQOgH94HDka_iB-QFVl4JA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="ukVxth2X9kSEkJeRYHLLRA" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="o5dVaNwCTU-sbEdD-HVk4A" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="Yn0d1-sWmkqROgnRPfBb7Q" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="unNersC77UO5rqnweADD6g" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="b2rU5FIdwEWAcdoGtLXqqA" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="QemVtHvzTkqxZfFqqUIC4g" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="MEoUFRsuEE2ikntfBVzjRQ" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="EPZRKu0ySEuc-PGwbF5VTQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="vgPWBudVgEWT7oaoLk4j4g" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="DEU46GWwYU6GIfAmUIKHBA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="6Ye6sYAS7U2SAWWmtKTVtQ" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="B2OZGhJxeUSzl63o4UyAvQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="hIV8YimvRUuZ5g36cJ6Byg" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="VwZNLj4Dv068bEXqYlOx7g" dim="Dimensionless" quantityType="0" />
-                        <Container id="4Q7zgvuqcE-QpUYXuYeQwA" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Plasma" />
-                            <Tag value="LowerJejunum" />
-                            <Tag value="Mucosa" />
-                            <Tag value="SmallIntestineSegment" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="_dJrGSoFcEqb5RlKokfuPg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="owgI66XQcE2ClB4BHV50ew" dim="Volume" quantityType="0" />
-                            <Parameter id="48t4ev-d-ESYQt6hVD4-Qw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="rbp4e7PXpUyuD1ZtA8Ocxw" dim="Volume" quantityType="0" />
-                            <MoleculeAmount id="IBK3hooVzE2t9QgNnGZ_0w" name="Drug" icon="Drug" persistable="0" isFixedValue="0" formula="cikr3fqTJkGNom52eIL3rg" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="j8AoMW9UbE6Hhcp0JVhQEA" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Parameter id="I4FShEusDkSgxFBln9-r0A" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="SzlNXvDBmU2VQn7B638P6w" dim="Dimensionless" quantityType="0" />
-                                <Observer id="EkrhaW4KfkW4hEVOph2UoQ" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Drug, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                            <MoleculeAmount id="uK5T_SndBEeflV0LOOPoGg" name="Cyp" icon="Enzyme" persistable="0" isFixedValue="0" formula="wb5yCXJZxUeVY_7iSBmoSg" dim="Amount" quantityType="Enzyme" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="Vrshrv8xgkCse__0AfAVMA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" formula="Xd4NN_mBPU6E4IGmtC9W9g" dim="Dimensionless" quantityType="0" />
-                                <Parameter id="ccRtSmQht0mmjAdFpSDkdQ" name="Relative expression out." description="Relative Expression that will be used in the simulation" persistable="0" isFixedValue="0" formula="GtBZCb_uvUKgURPKDkyZKA" dim="Fraction" quantityType="0" />
-                                <Parameter id="gyui8Wm9LEWyHcDhXEBsIg" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" persistable="0" isFixedValue="0" formula="Qv2OyMi-nU-kPqJ48WVuVw" dim="Fraction" quantityType="0" />
-                                <Parameter id="MREIsXTS9kyIVwtwPXBAQA" name="Relative expression" description="Relative expression" persistable="0" isFixedValue="0" formula="iUzjEbj_NkSh4u8TNBhFgQ" dim="Fraction" quantityType="0" />
-                                <Parameter id="WbKRf08eZUynLI8luBu9SQ" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Observer id="MS2od2k6okiBKMbr6tjQkQ" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Enzyme, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                            <MoleculeAmount id="OibEkOmGyUO-AQCf9mo3Sw" name="Drug-Cyp Metabolite" persistable="0" isFixedValue="0" formula="AfdUaNmub0a2iZ_xpj4h9w" dim="Amount" quantityType="Metabolite" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="7Q8Thk6ANUqqJcfCN7ctAQ" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Observer id="KJTb1HEwI0qJZVgpgEK5LQ" name="Fraction of dose" description="Metabolized fraction of administered dose" persistable="1" isFixedValue="0" formula="aUoTQ3n3a0OShljd8bUj3w" dim="Fraction" quantityType="Metabolite, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                            <Reaction id="aHUjUzp43U6iGUGojNdn5A" name="Cyp-ME" icon="Metabolism" mode="Logical" containerType="Other" dimension="Dimensionless" formula="NrKgrsKmwkiGET1q7OIPYg">
-                              <Educts>
-                                <ReactionPartner stoichiometricCoefficient="1" partner="IBK3hooVzE2t9QgNnGZ_0w" />
-                              </Educts>
-                              <Products>
-                                <ReactionPartner stoichiometricCoefficient="1" partner="OibEkOmGyUO-AQCf9mo3Sw" />
-                              </Products>
-                              <ModifierNames>
-                                <ModifierNamesChild>Cyp</ModifierNamesChild>
-                              </ModifierNames>
-                            </Reaction>
-                          </Children>
-                        </Container>
-                        <Container id="MN94QcuVH0aTgduRFgCruw" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="BloodCells" />
-                            <Tag value="LowerJejunum" />
-                            <Tag value="Mucosa" />
-                            <Tag value="SmallIntestineSegment" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="bAmkuqIftUm617tGgQxXpQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="owgI66XQcE2ClB4BHV50ew" dim="Volume" quantityType="0" />
-                            <Parameter id="qjsHUegCBESlmjCbsaH2zQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="tFZiRJ-Sv0qf0gsV7ycmYw" dim="Volume" quantityType="0" />
-                            <MoleculeAmount id="pkwIe2c8m0C2ShdFKX-RLw" name="Drug" icon="Drug" persistable="0" isFixedValue="0" formula="M4fyX16dSECM9Ber2yqlVA" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="9zbVH_Gr4k6Myye_6OH8qA" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Parameter id="LLO8_z2jFEuhqiCCMuoeKg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="rKinsmgbbkGSyNQdw6vu4A" dim="Dimensionless" quantityType="0" />
-                                <Observer id="SX_8vlQoLECpyoFsDxmskw" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Drug, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                            <MoleculeAmount id="FSi2KKwlOEC-X-J903h08w" name="Cyp" icon="Enzyme" persistable="0" isFixedValue="0" formula="wb5yCXJZxUeVY_7iSBmoSg" dim="Amount" quantityType="Enzyme" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="RSoaF-P-d0ucHXGbVzz2lw" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" formula="c0hAn73Y7k6hW4OQsPAA8Q" dim="Dimensionless" quantityType="0" />
-                                <Parameter id="CgDrRoQGRUGgPGG2KiVebA" name="Relative expression out." description="Relative Expression that will be used in the simulation" persistable="0" isFixedValue="0" formula="GtBZCb_uvUKgURPKDkyZKA" dim="Fraction" quantityType="0" />
-                                <Parameter id="pmAAGxjNM0OiPxG7CWiXmQ" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" persistable="0" isFixedValue="0" formula="FTxLv_b4CkKigLwWdcA4xg" dim="Fraction" quantityType="0" />
-                                <Parameter id="chk_p2ClQkqEvphlblk3_A" name="Relative expression" description="Relative expression" persistable="0" isFixedValue="0" formula="_J3C13ewoUatoCS2w-zxeg" dim="Fraction" quantityType="0" />
-                                <Parameter id="4o7VWg56Skq5TVgB3PGBWA" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Observer id="gMAuIXELKkqefklFFxHS3Q" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Enzyme, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                            <MoleculeAmount id="tAVVujSVeEm6UCI7gVi6AA" name="Drug-Cyp Metabolite" persistable="0" isFixedValue="0" formula="QJfXd-blzk2R_0kAy4Y9vQ" dim="Amount" quantityType="Metabolite" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="NJbyD9ajMEmt5pRGDOAvsg" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Observer id="gKvkH9cz8U-zZQb1QDb1rw" name="Fraction of dose" description="Metabolized fraction of administered dose" persistable="1" isFixedValue="0" formula="aUoTQ3n3a0OShljd8bUj3w" dim="Fraction" quantityType="Metabolite, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                            <Reaction id="_pn0uAYDk0Ckgcf1d33jMA" name="Cyp-ME" icon="Metabolism" mode="Logical" containerType="Other" dimension="Dimensionless" formula="NrKgrsKmwkiGET1q7OIPYg">
-                              <Educts>
-                                <ReactionPartner stoichiometricCoefficient="1" partner="pkwIe2c8m0C2ShdFKX-RLw" />
-                              </Educts>
-                              <Products>
-                                <ReactionPartner stoichiometricCoefficient="1" partner="tAVVujSVeEm6UCI7gVi6AA" />
-                              </Products>
-                              <ModifierNames>
-                                <ModifierNamesChild>Cyp</ModifierNamesChild>
-                              </ModifierNames>
-                            </Reaction>
-                          </Children>
-                        </Container>
-                        <Container id="5PomAWE2VkC-slCzt2mnVw" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Interstitial" />
-                            <Tag value="LowerJejunum" />
-                            <Tag value="Mucosa" />
-                            <Tag value="SmallIntestineSegment" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="gvMK6ZhRnEOsUj9Kh-sbsg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="owgI66XQcE2ClB4BHV50ew" dim="Volume" quantityType="0" />
-                            <Parameter id="lcyuu3M_YkiNDOHgyAa5mQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="4VSppd3W3E6-12kllCJ0Mg" dim="Volume" quantityType="0" />
-                            <Parameter id="KnuFdEor8U-9VYZXWUDfOQ" name="pH" description="pH" persistable="0" isFixedValue="0" formula="tKjHIxsi60KoHEPhXQBZrw" dim="Dimensionless" quantityType="0" />
-                            <MoleculeAmount id="5z92tYfgbEi8q7N6MN6VRQ" name="Drug" icon="Drug" persistable="0" isFixedValue="0" formula="GmSMrZaNxUqguuXc3YAq6Q" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="QbOpyh5WBkKAqyaDo-l7yA" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Parameter id="Ekjb5VBAXUuyyMq8OVJx5Q" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="xU9AecSXLU-zveFuNUWbdA" dim="Dimensionless" quantityType="0" />
-                                <Observer id="tcgZrHjq6EmnqVlE8KUwmg" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Drug, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                          </Children>
-                        </Container>
-                        <Container id="5vmKOnRiF06lebQSRhQJOg" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Intracellular" />
-                            <Tag value="IntestinalSecretionSource" />
-                            <Tag value="LowerJejunum" />
-                            <Tag value="Mucosa" />
-                            <Tag value="SmallIntestineSegment" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="GaskyJhvxUmdIbOjHQP9_w" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="M9arQg_qfEGMA7JdlSXkFA" dim="Volume" quantityType="0" />
-                            <Parameter id="1oWLFPQZZUaez5UGQmUejg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="3l84whkuX0S7xUUHglUQpg" dim="Volume" quantityType="0" />
-                            <Parameter id="nMVjWY7Kqk6WbUGfVUcqng" name="pH" description="pH" persistable="0" isFixedValue="0" formula="rKeT1uyEVky7Xm6KlBU-6A" dim="Dimensionless" quantityType="0" />
-                            <MoleculeAmount id="WWPxNCTxFUiGAAGb_xVXCQ" name="Drug" icon="Drug" persistable="0" isFixedValue="0" formula="AXdyDyxr8E2mrTUCiN1ghg" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="zjqwq2lAjE6NZwbRXrQqFQ" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Parameter id="kg0v0fzX1katVVwBtqzj7g" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="T42-ZZcePECARTdO6R7J5w" dim="Dimensionless" quantityType="0" />
-                                <Observer id="pkwaw-mDVUC9lfwGmqpHzQ" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Drug, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                            <MoleculeAmount id="-yA3lrMyyEOvSmtvVq_s5g" name="Cyp" icon="Enzyme" persistable="0" isFixedValue="0" formula="wb5yCXJZxUeVY_7iSBmoSg" dim="Amount" quantityType="Enzyme" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="wjtI7Pa4sUSPYsx7Q2YdOg" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" formula="iqMjuxbh6028MdFCAhEwKg" dim="Dimensionless" quantityType="0" />
-                                <Parameter id="9zt6SKymA0qTvA0UxeN0Ag" name="Relative expression out." description="Relative Expression that will be used in the simulation" persistable="0" isFixedValue="0" formula="GtBZCb_uvUKgURPKDkyZKA" dim="Fraction" quantityType="0" />
-                                <Parameter id="NuX9YnJJVUqDFLC_-ZtvMg" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" persistable="0" isFixedValue="0" formula="OrMJYNdzIUiZ9zQ_NfDW9w" dim="Fraction" quantityType="0" />
-                                <Parameter id="GXAeYkGgq06r0a4PMp35_w" name="Relative expression" description="Relative expression" persistable="0" isFixedValue="0" formula="WUmAd17Wz0GjPw6hiq0Ypw" dim="Fraction" quantityType="0" />
-                                <Parameter id="2U4N6yMuY0qjrHoCNfs11Q" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Observer id="OQtRB-5l2kuRv3o7s6Vypg" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Enzyme, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                            <MoleculeAmount id="hYwWzEAlFkaadLw70Ru-Wg" name="Drug-Cyp Metabolite" persistable="0" isFixedValue="0" formula="CcOSEBOr6UaDdCn6LxUtWw" dim="Amount" quantityType="Metabolite" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="DaWKRaoCx0WtiEupKOzJxw" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Observer id="91Xp77IKM0mJtxPqMa0z9w" name="Fraction of dose" description="Metabolized fraction of administered dose" persistable="1" isFixedValue="0" formula="aUoTQ3n3a0OShljd8bUj3w" dim="Fraction" quantityType="Metabolite, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                            <Reaction id="zBNEO8YC1UKE8KoyiG-m9Q" name="Cyp-ME" icon="Metabolism" mode="Logical" containerType="Other" dimension="Dimensionless" formula="NrKgrsKmwkiGET1q7OIPYg">
-                              <Educts>
-                                <ReactionPartner stoichiometricCoefficient="1" partner="WWPxNCTxFUiGAAGb_xVXCQ" />
-                              </Educts>
-                              <Products>
-                                <ReactionPartner stoichiometricCoefficient="1" partner="hYwWzEAlFkaadLw70Ru-Wg" />
-                              </Products>
-                              <ModifierNames>
-                                <ModifierNamesChild>Cyp</ModifierNamesChild>
-                              </ModifierNames>
-                            </Reaction>
-                          </Children>
-                        </Container>
-                      </Children>
-                    </Container>
-                    <Container id="gqtr0V4-r0Ogno0cUvdkdg" name="UpperIleum" description="Upper Ileum" icon="UpperIleum" mode="Logical" containerType="Compartment">
-                      <Tags>
-                        <Tag value="UpperIleum" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="55wTnHR810KslDWxJhGnFA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="kMAZQxq8bUyy5HlMX_Pptg" dim="Volume" quantityType="0" />
-                        <Parameter id="r8rb4S_CkkSFJxyqbAI3og" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" formula="6e9LHlTFJkG-PMFyieazhw" dim="Flow (volume)" quantityType="0" />
-                        <Parameter id="m0OXsPkpL0aHvKdHoPKfCA" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" formula="xiNULEV19USY00_wFEUSQQ" dim="Volume" quantityType="0" />
-                        <Parameter id="bq864mMXJU-jSll4LNqI2Q" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" formula="hB48fjDKB0aPhnPyDobY9g" dim="Flow (volume)" quantityType="0" />
-                        <Parameter id="33s76i8jkk-kzBjrR0-Mzg" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" formula="PSbm5ReMbUKRj9xRJC3ccA" dim="Flow (volume)" quantityType="0" />
-                        <Parameter id="5oVSzwtgBEyKa2qvkpuvmw" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" formula="FbGzbaLst0K5o2gc_gSjaQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="OBrxOrKHUUCjP_MI_tBDKg" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" formula="WGX8N7R7lUihRjz4Dm5BxQ" dim="Density" quantityType="0" />
-                        <Parameter id="orPHm6AJvUywD2IW7n6fwA" name="Fraction of regional blood flow rate" description="Regional blood flow fraction supplying the mucosal tissue of the segment" persistable="0" isFixedValue="0" formula="Z2l-2h3xcUSWKuUSRPVdBg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="FcfkLJLN10q6HG7oO6FI0g" name="Fraction mucosa" description="Mucosal fraction of regional intestinal tissue mass" persistable="0" isFixedValue="0" formula="etOHECa0OUu0Bb0i_j46Jw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="s_HAhS96WEGX1LyY81wApA" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" formula="K1bEgEHDb0akzOjDYgjhJA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="vu_F4y9X9EG4XieemBLLig" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" formula="mCqYX1NUnkuSgHB-eDft4Q" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="_4qxcr8hPECLP8vqh-k5Qw" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" formula="F75AKRo6fUev2jSmBSGr5w" dim="HydraulicConductivity" quantityType="0" />
-                        <Parameter id="ct06jpWt-UisGByjDxzLig" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" formula="iiW4tnS07kGRjbI9_eq6yw" dim="Nanolength" quantityType="0" />
-                        <Parameter id="fI9JJQYn-kGerUjIVhewdg" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" formula="IJMdbReRSkaXNnkzYk828w" dim="Nanolength" quantityType="0" />
-                        <Parameter id="5_ideKgKG0OoGvuBeMAafw" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="NFJtH8WA7U2smPvRg-Zg6Q" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="yLsoan4ORkWNCzQ5Cc2lxQ" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="fr7BQaxIE0KnOhvTpn1A1g" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="TbsqzKT1lkqWnchb6NljGA" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" formula="3XsYXi1jZ0esTLtpkI8seQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="iNrVnTAfY0-Lgeag3JGfDQ" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="z8HfddhbHUuDhc4l8bnB0Q" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="8oe3ZFI0mEe0tlK2uBS6-Q" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="vCVgFSnN-Eue_jekzk2S7g" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="79OO_K9ZR0aDckLRIfxBCA" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="q8ujKhkXxE6Sd1xIs2_E0A" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="lOdqhHCu8Uu9HLSAOvL53w" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="pVQlG_c4LkykyYufMNat9g" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="X89hOAUJEUm5O4J4ea8OoQ" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="TN4uQhtcKU-c9dF0plL08g" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="zGuTRI_e0k2FzpFGfEK92A" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="iCup-0TeUU6Lm4sPAt-m3w" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="locNIp0I9E2KRaPgmXjhCQ" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="Cd9-H7u28E-uo8yEPsqWJA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="oZ8XKOhi4Eio39iGg_PI7Q" name="Number of cells/g tissue" description="Number of cells per gram tissue" persistable="0" isFixedValue="0" formula="s_zh_nr3bkeaSgSnIl_6cA" dim="CellQuantityPerTissue" quantityType="0" />
-                        <Parameter id="ZAC3Ty80YECIfyAjoBTPYA" name="Protein mass/g tissue" description="Total protein content per gram tissue" persistable="0" isFixedValue="0" formula="R_y1d1PR-UqnvgEXGO0OWQ" dim="MassProteinPerTissue" quantityType="0" />
-                        <Parameter id="E9AJv5gv8EWkJlnsjXCMCw" name="Microsomal protein mass/g tissue" description="Microsomal protein content per gram tissue" persistable="0" isFixedValue="0" formula="2ASmb0WauU-3XL2xvC3KFw" dim="MassProteinPerTissue" quantityType="0" />
-                        <Parameter id="R6ev0qqCPkucU1kuNO9TUw" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" formula="D4oxNGKXcUC_w9UQaoXunw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="NW3_G-E6o02u7ETLETpDnQ" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="hTl3KXQY_UiLpU78vNAw_g" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="TJcoU14rdkmseouxOSRMwg" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="FZGGiyzLuEqgyGinGHoklA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="Uw3zL52Y20GvkHtxhKzo7w" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="_WJ23NLyD0KzhlVgzba7Eg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="U8xTAAvRZ0WW9e6iuL4ZfQ" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="mAJbRdBi6EK8DNobTEtm8Q" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="OnXlYA1_YEKYekjbVxh6zQ" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="ryEnCJRsck-70HBzN_1GUA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="-yheKZbyxECl7qgywACPyQ" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="q6NDwXQmP0ejByMTel82cA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="jhk5fBUMCE-KdC-dCq1y5Q" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="VvjwXwigV0WX1iTPoSr63w" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="Iqzy0Y-QTkujWrCrqymX2g" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="mw-gIHcrTkeFHEhJQSyc6Q" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="0EjiSJbnRE-pkTT0-WbGVQ" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="gwNuJrAGgEy0VW-b-ueYaA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="XWY83_VfXk2i4imxQBgvDQ" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="GKvvfjmLT0ejPxcQdEK_ow" dim="Dimensionless" quantityType="0" />
-                        <Container id="eqxADnXJ7U-yx7RZ9RRnGQ" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Plasma" />
-                            <Tag value="Mucosa" />
-                            <Tag value="SmallIntestineSegment" />
-                            <Tag value="UpperIleum" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="_Z1MTlDIdE-fbuCWFcMkWQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="owgI66XQcE2ClB4BHV50ew" dim="Volume" quantityType="0" />
-                            <Parameter id="VUnHwBV-c0Gipc4jSOJicQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="rbp4e7PXpUyuD1ZtA8Ocxw" dim="Volume" quantityType="0" />
-                            <MoleculeAmount id="3LnxhiZCq0-_1-jmaYhb8w" name="Drug" icon="Drug" persistable="0" isFixedValue="0" formula="P8qU9n2gukaTSC_uLjPC7w" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="7H0AY4AZkUOBLZgZv3ZeQg" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Parameter id="3Matw-RWcUe9N0H7B9ki2w" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="MXF1RLQf2kKzutcXy27SeA" dim="Dimensionless" quantityType="0" />
-                                <Observer id="GmpfbCSbI0mHS_UoqqVFBQ" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Drug, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                            <MoleculeAmount id="sc9epD-KkUCvVE-n0xZfFw" name="Cyp" icon="Enzyme" persistable="0" isFixedValue="0" formula="wb5yCXJZxUeVY_7iSBmoSg" dim="Amount" quantityType="Enzyme" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="DvuThvkO2EGyLsFCVptSZg" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" formula="h-qHdJIdf0i7vDR7QjgK5g" dim="Dimensionless" quantityType="0" />
-                                <Parameter id="5h-QqrCI402GsjW6L4kRWw" name="Relative expression out." description="Relative Expression that will be used in the simulation" persistable="0" isFixedValue="0" formula="GtBZCb_uvUKgURPKDkyZKA" dim="Fraction" quantityType="0" />
-                                <Parameter id="sGreUDbF3kehDkZNv1R5fg" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" persistable="0" isFixedValue="0" formula="Qv2OyMi-nU-kPqJ48WVuVw" dim="Fraction" quantityType="0" />
-                                <Parameter id="XBk7mdhtOEiIgLxBslXhRQ" name="Relative expression" description="Relative expression" persistable="0" isFixedValue="0" formula="iUzjEbj_NkSh4u8TNBhFgQ" dim="Fraction" quantityType="0" />
-                                <Parameter id="dzX1rOQsyUK41DWGNx7HAw" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Observer id="sL6s3hoTEEiodbbONp3AYA" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Enzyme, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                            <MoleculeAmount id="vpJf5l9ozk2WzfInUP0kuA" name="Drug-Cyp Metabolite" persistable="0" isFixedValue="0" formula="1NKjhPSb3UWdpeT-YrjpNw" dim="Amount" quantityType="Metabolite" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="xx8VOqJ-a0eleUXAY9Y41Q" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Observer id="qbXnWivm2Uyi7AQgVGZe7w" name="Fraction of dose" description="Metabolized fraction of administered dose" persistable="1" isFixedValue="0" formula="aUoTQ3n3a0OShljd8bUj3w" dim="Fraction" quantityType="Metabolite, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                            <Reaction id="c_vGlwTMRUeRJPPDx7NNkg" name="Cyp-ME" icon="Metabolism" mode="Logical" containerType="Other" dimension="Dimensionless" formula="NrKgrsKmwkiGET1q7OIPYg">
-                              <Educts>
-                                <ReactionPartner stoichiometricCoefficient="1" partner="3LnxhiZCq0-_1-jmaYhb8w" />
-                              </Educts>
-                              <Products>
-                                <ReactionPartner stoichiometricCoefficient="1" partner="vpJf5l9ozk2WzfInUP0kuA" />
-                              </Products>
-                              <ModifierNames>
-                                <ModifierNamesChild>Cyp</ModifierNamesChild>
-                              </ModifierNames>
-                            </Reaction>
-                          </Children>
-                        </Container>
-                        <Container id="O523UhgKSkeprp67LMaDag" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="BloodCells" />
-                            <Tag value="Mucosa" />
-                            <Tag value="SmallIntestineSegment" />
-                            <Tag value="UpperIleum" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="raNM5euRl0WUeT6vMVRPJg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="owgI66XQcE2ClB4BHV50ew" dim="Volume" quantityType="0" />
-                            <Parameter id="0Ag1bIDVjkeVuquYt_ROMQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="tFZiRJ-Sv0qf0gsV7ycmYw" dim="Volume" quantityType="0" />
-                            <MoleculeAmount id="W8KLhlsWkU6-nxbVlLgfDA" name="Drug" icon="Drug" persistable="0" isFixedValue="0" formula="6WZlUtNwokmZwZRf04Cfng" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="1f3Kje94U0OigVejUKPShw" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Parameter id="ZaR1zRTiHE6tZTaKuzMYWA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="GVT2W2dzGECKli5FTXcv-Q" dim="Dimensionless" quantityType="0" />
-                                <Observer id="2LY5hi-oZEaC4UDcueDQ9A" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Drug, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                            <MoleculeAmount id="IfkvvqqvDUqVrnG35OxtTA" name="Cyp" icon="Enzyme" persistable="0" isFixedValue="0" formula="wb5yCXJZxUeVY_7iSBmoSg" dim="Amount" quantityType="Enzyme" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="4btZG9qJzkKaY6fFrpOxZg" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" formula="g__mu7hxXU6Pqri3LCqf1g" dim="Dimensionless" quantityType="0" />
-                                <Parameter id="Lq4AubkTd0yMWPyRSKC90A" name="Relative expression out." description="Relative Expression that will be used in the simulation" persistable="0" isFixedValue="0" formula="GtBZCb_uvUKgURPKDkyZKA" dim="Fraction" quantityType="0" />
-                                <Parameter id="4vb_vxAogUOWGuVWwPyWTg" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" persistable="0" isFixedValue="0" formula="FTxLv_b4CkKigLwWdcA4xg" dim="Fraction" quantityType="0" />
-                                <Parameter id="qvnVaPM9c0KkK3SLajo_JA" name="Relative expression" description="Relative expression" persistable="0" isFixedValue="0" formula="_J3C13ewoUatoCS2w-zxeg" dim="Fraction" quantityType="0" />
-                                <Parameter id="OQ3B3AnItkm1BbcG7PHJ2g" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Observer id="8LB14CxmIkm2ACoNv1vxsw" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Enzyme, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                            <MoleculeAmount id="isemA3FQfEKn2fTTkIENDg" name="Drug-Cyp Metabolite" persistable="0" isFixedValue="0" formula="sHivuZ9ge0SyPI2HPoWPlQ" dim="Amount" quantityType="Metabolite" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="u5T2BGIHDE-PZI9LbFukyA" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Observer id="tZ8xVImhvka4JjJ19OfP9Q" name="Fraction of dose" description="Metabolized fraction of administered dose" persistable="1" isFixedValue="0" formula="aUoTQ3n3a0OShljd8bUj3w" dim="Fraction" quantityType="Metabolite, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                            <Reaction id="eNjuY2gQRUWziMvR9sYp0g" name="Cyp-ME" icon="Metabolism" mode="Logical" containerType="Other" dimension="Dimensionless" formula="NrKgrsKmwkiGET1q7OIPYg">
-                              <Educts>
-                                <ReactionPartner stoichiometricCoefficient="1" partner="W8KLhlsWkU6-nxbVlLgfDA" />
-                              </Educts>
-                              <Products>
-                                <ReactionPartner stoichiometricCoefficient="1" partner="isemA3FQfEKn2fTTkIENDg" />
-                              </Products>
-                              <ModifierNames>
-                                <ModifierNamesChild>Cyp</ModifierNamesChild>
-                              </ModifierNames>
-                            </Reaction>
-                          </Children>
-                        </Container>
-                        <Container id="h_HrULaBNU63NUv9o6Picg" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Interstitial" />
-                            <Tag value="Mucosa" />
-                            <Tag value="SmallIntestineSegment" />
-                            <Tag value="UpperIleum" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="-lfoSpLf8k6HJW7GkmfJvQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="owgI66XQcE2ClB4BHV50ew" dim="Volume" quantityType="0" />
-                            <Parameter id="N9slW3BVjUa7pTzFcO6jjw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="4VSppd3W3E6-12kllCJ0Mg" dim="Volume" quantityType="0" />
-                            <Parameter id="q1YBEkMZOECt8I9D4jsEWA" name="pH" description="pH" persistable="0" isFixedValue="0" formula="tKjHIxsi60KoHEPhXQBZrw" dim="Dimensionless" quantityType="0" />
-                            <MoleculeAmount id="p0ZWuAT6gE-MyE4o81OmDA" name="Drug" icon="Drug" persistable="0" isFixedValue="0" formula="dMrXGU_1Kk-DOPyOa18rcA" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="jvz53YKxXUWUZTrl2n4oYw" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Parameter id="qaeHbyT2XEuujZDzDXVh_g" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="wNndkLBWVk-9FbTk3nCAnA" dim="Dimensionless" quantityType="0" />
-                                <Observer id="0A076tgUW0KdJepo9HSiaw" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Drug, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                          </Children>
-                        </Container>
-                        <Container id="gBiM91b0lEOFJj41Hgmg7Q" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Intracellular" />
-                            <Tag value="IntestinalSecretionSource" />
-                            <Tag value="Mucosa" />
-                            <Tag value="SmallIntestineSegment" />
-                            <Tag value="UpperIleum" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="6SIgGeFibEGFCbfO6b2O-A" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="M9arQg_qfEGMA7JdlSXkFA" dim="Volume" quantityType="0" />
-                            <Parameter id="JMD4fAAGvkqfokFljwEn3g" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="3l84whkuX0S7xUUHglUQpg" dim="Volume" quantityType="0" />
-                            <Parameter id="bNlZjeibrU2bDN8l15ScWQ" name="pH" description="pH" persistable="0" isFixedValue="0" formula="P-MyVLoyJUuDBO8T7omxeQ" dim="Dimensionless" quantityType="0" />
-                            <MoleculeAmount id="mGYOXZMgJUGhksXmlLzipQ" name="Drug" icon="Drug" persistable="0" isFixedValue="0" formula="sZ9_vPESd0ePxapf-9pRwg" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="tVPlcrSKYE6cwbDrq6DJLg" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Parameter id="5kAZ1_ek20OAnE2-NGGZJQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="wYM6Fv_5EkawQi6RKxft9A" dim="Dimensionless" quantityType="0" />
-                                <Observer id="kY8CNbkq3UCUVb5dJjh_vg" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Drug, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                            <MoleculeAmount id="b9UtTYbut0OL-h6JDWoszA" name="Cyp" icon="Enzyme" persistable="0" isFixedValue="0" formula="wb5yCXJZxUeVY_7iSBmoSg" dim="Amount" quantityType="Enzyme" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="G3oxVNsRj06KM8Ah9BPQ-w" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" formula="7G1MneyD3UKQU4zDm-rIcg" dim="Dimensionless" quantityType="0" />
-                                <Parameter id="0-00fSkT2UyFiQRnX9ZIcg" name="Relative expression out." description="Relative Expression that will be used in the simulation" persistable="0" isFixedValue="0" formula="GtBZCb_uvUKgURPKDkyZKA" dim="Fraction" quantityType="0" />
-                                <Parameter id="aLjr_-PszEih6Spi6TtazA" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" persistable="0" isFixedValue="0" formula="IAQaoJGFyU2nf729OvY7cQ" dim="Fraction" quantityType="0" />
-                                <Parameter id="VlLZ-Pxut0ah-ZdUbTKGEQ" name="Relative expression" description="Relative expression" persistable="0" isFixedValue="0" formula="Gs-wZyyKSkG1y-tG7kF9Ag" dim="Fraction" quantityType="0" />
-                                <Parameter id="Hvr52ZtjOUOCrdkAsPgv-Q" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Observer id="Hn8FxYLpgUOws27tzhKAXQ" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Enzyme, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                            <MoleculeAmount id="sfoZhvqWp0C2TC-OpKe8aw" name="Drug-Cyp Metabolite" persistable="0" isFixedValue="0" formula="SBZofe3J8U-gWKF9isHRCQ" dim="Amount" quantityType="Metabolite" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="3R0TnLjDeUSFhCKBPnikFg" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Observer id="Lrgu7fYrvUiOIW4ZfPAZmA" name="Fraction of dose" description="Metabolized fraction of administered dose" persistable="1" isFixedValue="0" formula="aUoTQ3n3a0OShljd8bUj3w" dim="Fraction" quantityType="Metabolite, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                            <Reaction id="DgjCIrmFQ0m73-rTQ-8j2w" name="Cyp-ME" icon="Metabolism" mode="Logical" containerType="Other" dimension="Dimensionless" formula="NrKgrsKmwkiGET1q7OIPYg">
-                              <Educts>
-                                <ReactionPartner stoichiometricCoefficient="1" partner="mGYOXZMgJUGhksXmlLzipQ" />
-                              </Educts>
-                              <Products>
-                                <ReactionPartner stoichiometricCoefficient="1" partner="sfoZhvqWp0C2TC-OpKe8aw" />
-                              </Products>
-                              <ModifierNames>
-                                <ModifierNamesChild>Cyp</ModifierNamesChild>
-                              </ModifierNames>
-                            </Reaction>
-                          </Children>
-                        </Container>
-                      </Children>
-                    </Container>
-                    <Container id="5ZtVLvzDVUWaLF5GOMaimA" name="LowerIleum" description="Lower Ileum" icon="LowerIleum" mode="Logical" containerType="Compartment">
-                      <Tags>
-                        <Tag value="LowerIleum" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="3YMNG-L-DU2A6lBaxfDMWA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="G5hhljVDr0y8YOkuoGUZsA" dim="Volume" quantityType="0" />
-                        <Parameter id="zttoMVD7ZUWrhtv49yzQyg" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" formula="6e9LHlTFJkG-PMFyieazhw" dim="Flow (volume)" quantityType="0" />
-                        <Parameter id="bYrD6E0lGUiniPQ7wJG7og" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" formula="hB48fjDKB0aPhnPyDobY9g" dim="Flow (volume)" quantityType="0" />
-                        <Parameter id="Qc_uMX1J70aE5gjynKJ50Q" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" formula="MDGIh-dSzECMJZnv2V5MQA" dim="Volume" quantityType="0" />
-                        <Parameter id="fQUXFdB1lkadvEhj5C8Lzg" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" formula="PSbm5ReMbUKRj9xRJC3ccA" dim="Flow (volume)" quantityType="0" />
-                        <Parameter id="mJdJzx9dhUiP_r2n53ZWKQ" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" formula="FbGzbaLst0K5o2gc_gSjaQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="ZlDjxGtQAEW_-ecyHNsT-A" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" formula="pBLmsTIFjUqDyVVhZCdlvA" dim="Density" quantityType="0" />
-                        <Parameter id="RfM1dAdl4UCuV6mTBdrZQQ" name="Fraction mucosa" description="Mucosal fraction of regional intestinal tissue mass" persistable="0" isFixedValue="0" formula="UQ2LvW1P_Ea2fkW6wQf0QA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="yCTjqkl3VUiGrM0Dv1J36g" name="Fraction of regional blood flow rate" description="Regional blood flow fraction supplying the mucosal tissue of the segment" persistable="0" isFixedValue="0" formula="jak8_Wv9u0aLgu4u4c3Rfw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="Vi9dXdmFX0SXrgxqEg_ndg" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" formula="CvIXwul0U0e7-HZpWJRTWQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="BblhltIIi02QwkAW99vGXA" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" formula="2YMft5C-H0iCWFArHhVyEw" dim="Nanolength" quantityType="0" />
-                        <Parameter id="d5KDCsnhJ0ayGBsKmLDbqQ" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" formula="J75rNuU7aUOTjljHH1O-7Q" dim="Nanolength" quantityType="0" />
-                        <Parameter id="JibwMupElUWyjfYHs7VKKQ" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" formula="fBneec5QdkmbUqy4VQz-JA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="FiJ_dqhYxkK7bqvylsm5gg" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" formula="B6qctjwrv0KmOwRFY1ZtIw" dim="HydraulicConductivity" quantityType="0" />
-                        <Parameter id="3SG7aVytk0a4FwZIPyu_VQ" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="bT3HJtzoyUaxuJkhkRT73g" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="_mhyvfVa-0-RVfwlUOhR2Q" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="9sRcMCwtQ0KyPUwNIDt7Lw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="Z9D68_zW_UeoBGuBb9EYgQ" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" formula="febv5u9Zp0GjGLhrOjUZKw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="QnZJDJTWqUahP1uCmaW5zw" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="2TOZ4n8CSkSxO3qH9-OFJA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="DWWGfChhlUSGnExEmSQa8w" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="1lHca9UOV0abBKwIX4GQ0A" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="IPR0s6czrEu7HOvvL7B0WA" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="hQ_9XTOg-k-19SsPTtpsJQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="hyqgbvcmwUy6Jtjlqsdo4A" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="OpKV5HztCUOYOeWWqoznQg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="JI1zQwuq-0imcCZ-jPmtdw" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="zKzoc83SjEyldiKpHt8fog" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="N1PydXR9f0e_Qr1ND16nUg" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="5MApL1JvdECOq2pFxjat9A" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="fD7gQaM4IUehRNPe7SuuEQ" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="vZBTc1Cp7k6rW2_zFN1pqA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="VBv1pRWNLE6UioZw3ym6Nw" name="Protein mass/g tissue" description="Total protein content per gram tissue" persistable="0" isFixedValue="0" formula="aZinu6af5U6sWK3cqyVuJw" dim="MassProteinPerTissue" quantityType="0" />
-                        <Parameter id="Z0YoCi7-tE-9VBBCYTxqsQ" name="Microsomal protein mass/g tissue" description="Microsomal protein content per gram tissue" persistable="0" isFixedValue="0" formula="64lhtUXJdkmxv3Om9Lf9fw" dim="MassProteinPerTissue" quantityType="0" />
-                        <Parameter id="dnpDdNr2tU2zJVnOpVo-TA" name="Number of cells/g tissue" description="Number of cells per gram tissue" persistable="0" isFixedValue="0" formula="q_2U0ItWLkWf5MzqHr6lDA" dim="CellQuantityPerTissue" quantityType="0" />
-                        <Parameter id="o1RETNfa-0CkERZLXOqfRQ" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" formula="MBxXFQBxYUidsKJglwKKvw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="bxBLaUvbM06PUKvdIWvtrA" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="ra455nMULEyDF3eEvzpEKA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="-HgCyd8WiESWHLjooLoPaA" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="oFukFYfqzEyn5I_p3pvijA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="G9fjROQQjkexv3lY8kF5ZQ" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="0Ti4hSSpi0WZjoPdm6KkFQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="5nZtm-ucK0m0bRXNZgQTxQ" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="BWs9K08Ss0-x-2sRQyo-FA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="EKJP7z_LUkSmLHn9AY45EQ" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="5sAp4L_7wEWtlLmNdIdJCA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="p-ftMe5HGk2L7zFdM6XRrA" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="I_LQqTEJNU-qs4-BPNgJBA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="EkXc_GaCP0urlHuPwSsITw" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="7PNSdlgbl0aG5CVGuh6OAQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="8kupPhM9nEm8MxGXpEZvdg" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="KW-H1R1F4Ei9dWR9xj3c8Q" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="BXEgtwXv9UC6q5ohmRS4uA" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="x2E11PrMmU25iMwxfqRgfA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="BUUmnJ4PLUCGNBefgDQ6cw" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="JTzedZdPAEyvWH2TCPgY1A" dim="Dimensionless" quantityType="0" />
-                        <Container id="2U7EZ2uO6USg9Rq74oJ7og" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Plasma" />
-                            <Tag value="LowerIleum" />
-                            <Tag value="Mucosa" />
-                            <Tag value="SmallIntestineSegment" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="tIn3cWIuy0KIq-WGSV3mpA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="owgI66XQcE2ClB4BHV50ew" dim="Volume" quantityType="0" />
-                            <Parameter id="HjLS5MUBSk-RG7-xuhGtfQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="rbp4e7PXpUyuD1ZtA8Ocxw" dim="Volume" quantityType="0" />
-                            <MoleculeAmount id="bh7HbBF4F0WuPbCIz5_eSQ" name="Drug" icon="Drug" persistable="0" isFixedValue="0" formula="w6N9MuRFPUSY79PskQZXww" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="6kddjD5rd0KZ9oBSkMtkEw" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Parameter id="heEgwwcgA0GV0UFvdL_mvg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="6zIcs1nEWkOWHXgZOKSLUQ" dim="Dimensionless" quantityType="0" />
-                                <Observer id="4Fa-yCelRkqslY4_4GDV3w" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Drug, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                            <MoleculeAmount id="sPnsUweW8UqcD07tmzhndg" name="Cyp" icon="Enzyme" persistable="0" isFixedValue="0" formula="wb5yCXJZxUeVY_7iSBmoSg" dim="Amount" quantityType="Enzyme" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="tSq4qnK_cE6iaba1-x9F7A" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" formula="OyaSm2l7ckK31RvUx4-LOg" dim="Dimensionless" quantityType="0" />
-                                <Parameter id="zYARaiJro0m8_9oJFA-NGw" name="Relative expression out." description="Relative Expression that will be used in the simulation" persistable="0" isFixedValue="0" formula="GtBZCb_uvUKgURPKDkyZKA" dim="Fraction" quantityType="0" />
-                                <Parameter id="rs_5MclkiU2eDMTsH0_Rsg" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" persistable="0" isFixedValue="0" formula="Qv2OyMi-nU-kPqJ48WVuVw" dim="Fraction" quantityType="0" />
-                                <Parameter id="vBWznf2Uc0CoO3DYnrarvQ" name="Relative expression" description="Relative expression" persistable="0" isFixedValue="0" formula="iUzjEbj_NkSh4u8TNBhFgQ" dim="Fraction" quantityType="0" />
-                                <Parameter id="zkB8u-G1aECgiJ52P-9X-Q" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Observer id="RjGUqXUhhUK6he4vmqGpBw" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Enzyme, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                            <MoleculeAmount id="5oH6miuBKUqQvlzibzejhA" name="Drug-Cyp Metabolite" persistable="0" isFixedValue="0" formula="-UgU5MFY7U2RXiQfjPFuZQ" dim="Amount" quantityType="Metabolite" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="9Wt7kyfLXkqhStduwoquGQ" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Observer id="oDrIGz66Rk60ouz3x81m8g" name="Fraction of dose" description="Metabolized fraction of administered dose" persistable="1" isFixedValue="0" formula="aUoTQ3n3a0OShljd8bUj3w" dim="Fraction" quantityType="Metabolite, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                            <Reaction id="t97PbdpFxkCYsPp_1E661A" name="Cyp-ME" icon="Metabolism" mode="Logical" containerType="Other" dimension="Dimensionless" formula="NrKgrsKmwkiGET1q7OIPYg">
-                              <Educts>
-                                <ReactionPartner stoichiometricCoefficient="1" partner="bh7HbBF4F0WuPbCIz5_eSQ" />
-                              </Educts>
-                              <Products>
-                                <ReactionPartner stoichiometricCoefficient="1" partner="5oH6miuBKUqQvlzibzejhA" />
-                              </Products>
-                              <ModifierNames>
-                                <ModifierNamesChild>Cyp</ModifierNamesChild>
-                              </ModifierNames>
-                            </Reaction>
-                          </Children>
-                        </Container>
-                        <Container id="y0laXWaK_0ejrydIy9XoSA" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="BloodCells" />
-                            <Tag value="LowerIleum" />
-                            <Tag value="Mucosa" />
-                            <Tag value="SmallIntestineSegment" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="PcZHK-4ej0-_BaRGRvrjbQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="owgI66XQcE2ClB4BHV50ew" dim="Volume" quantityType="0" />
-                            <Parameter id="AMkf8dXai0y8g0rm-NlTZA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="tFZiRJ-Sv0qf0gsV7ycmYw" dim="Volume" quantityType="0" />
-                            <MoleculeAmount id="FMCNNfjTpk2M8Oq8kAgVDA" name="Drug" icon="Drug" persistable="0" isFixedValue="0" formula="jiKRH-xMnUaAh4h_rzazuw" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1">
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-                                <Parameter id="t-kB-EtHWUuqF0A8FbFSGA" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Parameter id="QnnshKhYuUSkjf1OVmogog" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="oAkC1Wtp7EGe24Nj6UG_fg" dim="Dimensionless" quantityType="0" />
-                                <Observer id="wgrv9zSwWEWVStpsnmYSkg" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Drug, Observer" />
-                              </Children>
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-                            <MoleculeAmount id="AaA_GzJgGky8rhtt0RlQ8A" name="Cyp" icon="Enzyme" persistable="0" isFixedValue="0" formula="wb5yCXJZxUeVY_7iSBmoSg" dim="Amount" quantityType="Enzyme" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="tpAb1ZzXbkmqzVyCYKLoXg" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" formula="H4Twmub2ikOv7pqRyeNZ4w" dim="Dimensionless" quantityType="0" />
-                                <Parameter id="zTVSPo5ThEuMyHibSBW3UA" name="Relative expression out." description="Relative Expression that will be used in the simulation" persistable="0" isFixedValue="0" formula="GtBZCb_uvUKgURPKDkyZKA" dim="Fraction" quantityType="0" />
-                                <Parameter id="RfQyeMG2uU6m5lZZOmA_2w" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" persistable="0" isFixedValue="0" formula="FTxLv_b4CkKigLwWdcA4xg" dim="Fraction" quantityType="0" />
-                                <Parameter id="SzcxVEAnY0Wm_5rHhPuVnQ" name="Relative expression" description="Relative expression" persistable="0" isFixedValue="0" formula="_J3C13ewoUatoCS2w-zxeg" dim="Fraction" quantityType="0" />
-                                <Parameter id="esssQe0i0UiNUWg6SGdl6w" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Observer id="iJQVxYgLKUaozJxXMBbY6Q" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Enzyme, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                            <MoleculeAmount id="j_koxBWrH0m0eV_VjnCyRQ" name="Drug-Cyp Metabolite" persistable="0" isFixedValue="0" formula="wM6juA6iNESZ6drK56mCfw" dim="Amount" quantityType="Metabolite" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="GVznbRVot0-m5FdzaEKE-Q" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Observer id="9KUEqEkLZEqCuPM6q6dCxw" name="Fraction of dose" description="Metabolized fraction of administered dose" persistable="1" isFixedValue="0" formula="aUoTQ3n3a0OShljd8bUj3w" dim="Fraction" quantityType="Metabolite, Observer" />
-                              </Children>
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-                            <Reaction id="ybmzEn3jykuJVZWNIVPzSw" name="Cyp-ME" icon="Metabolism" mode="Logical" containerType="Other" dimension="Dimensionless" formula="NrKgrsKmwkiGET1q7OIPYg">
-                              <Educts>
-                                <ReactionPartner stoichiometricCoefficient="1" partner="FMCNNfjTpk2M8Oq8kAgVDA" />
-                              </Educts>
-                              <Products>
-                                <ReactionPartner stoichiometricCoefficient="1" partner="j_koxBWrH0m0eV_VjnCyRQ" />
-                              </Products>
-                              <ModifierNames>
-                                <ModifierNamesChild>Cyp</ModifierNamesChild>
-                              </ModifierNames>
-                            </Reaction>
-                          </Children>
-                        </Container>
-                        <Container id="40GEupwcu0KOCUrSxYbAIg" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Interstitial" />
-                            <Tag value="LowerIleum" />
-                            <Tag value="Mucosa" />
-                            <Tag value="SmallIntestineSegment" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="6L9TZ-VDp06cXCs9hjyvrQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="owgI66XQcE2ClB4BHV50ew" dim="Volume" quantityType="0" />
-                            <Parameter id="h_u78XlEhkWXtl5E3NNO4Q" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="4VSppd3W3E6-12kllCJ0Mg" dim="Volume" quantityType="0" />
-                            <Parameter id="iFvot5kDdUO3CCEW9VT_ig" name="pH" description="pH" persistable="0" isFixedValue="0" formula="tKjHIxsi60KoHEPhXQBZrw" dim="Dimensionless" quantityType="0" />
-                            <MoleculeAmount id="-D_MAFpGl0miz5YGijWeeQ" name="Drug" icon="Drug" persistable="0" isFixedValue="0" formula="2Azdasp2202Z2a1N1B_9mg" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="jeuCYbWB3kKUQLUJ75mEYA" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Parameter id="2goRMcWrikeTJ2lRDrWWYQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="hK5fVN7hJUGHgcwOcXHYCA" dim="Dimensionless" quantityType="0" />
-                                <Observer id="SfqKW0vMdkq1-CCApE1xBw" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Drug, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                          </Children>
-                        </Container>
-                        <Container id="pZKqZ19W4kqEFXqZkxgETw" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Intracellular" />
-                            <Tag value="IntestinalSecretionSource" />
-                            <Tag value="LowerIleum" />
-                            <Tag value="Mucosa" />
-                            <Tag value="SmallIntestineSegment" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="mpGxZVE-HEeHlYbCDvxAKw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="M9arQg_qfEGMA7JdlSXkFA" dim="Volume" quantityType="0" />
-                            <Parameter id="N_YAXlR82E2edRZcazhthg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="3l84whkuX0S7xUUHglUQpg" dim="Volume" quantityType="0" />
-                            <Parameter id="q8MkA1djUE6CBYo7iKoWxw" name="pH" description="pH" persistable="0" isFixedValue="0" formula="XwD2PtDvcUKVaHanAumrUA" dim="Dimensionless" quantityType="0" />
-                            <MoleculeAmount id="RReUSXdPAki3FARiRF47pg" name="Drug" icon="Drug" persistable="0" isFixedValue="0" formula="K7G5NoLg9U2LGtopUxpFEg" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1">
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-                                <Parameter id="-8DXcA1Ty0eO2Re0WWDBSg" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Parameter id="Ynqt9NLQ1UOMz4qaZN1Lsw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="jG4QzDxMNU-zQSCB3QIZ0g" dim="Dimensionless" quantityType="0" />
-                                <Observer id="NU3f3g3plk-CalpNpjnV7w" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Drug, Observer" />
-                              </Children>
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-                            <MoleculeAmount id="2SlmF1WFREOLV5Nc2dBI4w" name="Cyp" icon="Enzyme" persistable="0" isFixedValue="0" formula="wb5yCXJZxUeVY_7iSBmoSg" dim="Amount" quantityType="Enzyme" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="dbzPqsPDmE2re1C3GZujcg" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" formula="bNDjBDJdv0qNT7dedxgH3g" dim="Dimensionless" quantityType="0" />
-                                <Parameter id="A5yc5q_G1UyH4kRdgm7w7Q" name="Relative expression out." description="Relative Expression that will be used in the simulation" persistable="0" isFixedValue="0" formula="GtBZCb_uvUKgURPKDkyZKA" dim="Fraction" quantityType="0" />
-                                <Parameter id="jaGhdNBK-kSGGEGXcGAcdQ" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" persistable="0" isFixedValue="0" formula="uF4NdJKCck2JmfRzpWdF5A" dim="Fraction" quantityType="0" />
-                                <Parameter id="UTC_dFONLkm34t44ZHocGg" name="Relative expression" description="Relative expression" persistable="0" isFixedValue="0" formula="-Cfk5ubrlEKtlBnOLzEbrQ" dim="Fraction" quantityType="0" />
-                                <Parameter id="-XFA39PyDEqHqrpKT_YGBw" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
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-                              </Children>
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-                            <MoleculeAmount id="4HuWJ0uaU0GatGqEuZwPzQ" name="Drug-Cyp Metabolite" persistable="0" isFixedValue="0" formula="CmJogX6iNkyyx8Tx30r3hg" dim="Amount" quantityType="Metabolite" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="3AQ-V0M5OUqc-MOMaj465g" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Observer id="a9bDbq4w_0GCJXpbenDNAg" name="Fraction of dose" description="Metabolized fraction of administered dose" persistable="1" isFixedValue="0" formula="aUoTQ3n3a0OShljd8bUj3w" dim="Fraction" quantityType="Metabolite, Observer" />
-                              </Children>
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-                            <Reaction id="Whpcmp0oh0-mzqgWBquYLw" name="Cyp-ME" icon="Metabolism" mode="Logical" containerType="Other" dimension="Dimensionless" formula="NrKgrsKmwkiGET1q7OIPYg">
-                              <Educts>
-                                <ReactionPartner stoichiometricCoefficient="1" partner="RReUSXdPAki3FARiRF47pg" />
-                              </Educts>
-                              <Products>
-                                <ReactionPartner stoichiometricCoefficient="1" partner="4HuWJ0uaU0GatGqEuZwPzQ" />
-                              </Products>
-                              <ModifierNames>
-                                <ModifierNamesChild>Cyp</ModifierNamesChild>
-                              </ModifierNames>
-                            </Reaction>
-                          </Children>
-                        </Container>
-                      </Children>
-                    </Container>
-                  </Children>
-                </Container>
-                <Container id="cSTcNJL3W0SLG_UByiEgeg" name="Drug" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Observer id="a49JdizazkCr4WKs19G51A" name="Interstitial Unbound" description="Interstitial Unbound" persistable="1" isFixedValue="0" formula="sb2EI4hIhEWxy5ZYMY2QFw" dim="MolarConcentration" quantityType="Drug, Observer" />
-                    <Observer id="-XbIJkYH40eiFqSZhJr3yg" name="Intracellular Unbound" description="Intracellular Unbound" persistable="1" isFixedValue="0" formula="F5kFVlFTnEmJToE6fKssfA" dim="MolarConcentration" quantityType="Drug, Observer" />
-                    <Observer id="kjj9KqWjxUqN-MCLrLobyQ" name="Total Tissue (Small Intestine)" description="Mucosa and nonmucosa tissue" persistable="1" isFixedValue="0" formula="q40woo9HeUiW96XigCeQAQ" dim="MolarConcentration" quantityType="Drug, Observer" />
-                  </Children>
-                </Container>
-              </Children>
-            </Container>
-            <Container id="eRihyQr_u0iVn9Yv1_mPCw" name="LargeIntestine" description="LargeIntestine" icon="LargeIntestine" mode="Logical" containerType="Organ">
-              <Tags>
-                <Tag value="LargeIntestine" />
-                <Tag value="Portal Vein Supplying Organ" />
-                <Tag value="TissueOrgan" />
-              </Tags>
-              <Children>
-                <Parameter id="zWXPtx9RZUGSgcXmIkjEhw" name="Large intestinal transit time factor" description="Large intestinal transit time factor" persistable="0" isFixedValue="0" formula="7f4PilSqbUCusXQZTw9W0g" dim="Dimensionless" quantityType="0" />
-                <Parameter id="c4DRb37b5UWgaJdNAZsljQ" name="Volume (mucosa)" description="Volume of mucosa" persistable="0" isFixedValue="0" formula="7yCpaszz3U2f9Li_XLgKXA" dim="Volume" quantityType="0" />
-                <Parameter id="UAnmfEzJwEuEeriMdgfvTg" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" formula="isV2zRNj6U6N75F_2CcjBA" dim="Volume" quantityType="0" />
-                <Parameter id="cX74J3kYoUG3Tm5smg5RXA" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" formula="T3a9auJ-lEOiLdEnRq14gQ" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="v-c6W-2VG0yox-xYzQkBQw" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" formula="Fr0DGgHy5UiBvEp262AunA" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="jFsO54z4gECH14xTW5tKZw" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" formula="FbGzbaLst0K5o2gc_gSjaQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="JFvodZ9w4U6ObMUD-fKjLA" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" formula="mVEWvGqrgE-KcEv8JHNkQw" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="W_vP4CIRo06lrzqZ8WgWrw" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" persistable="0" isFixedValue="0" formula="b125MTUBXkCmLj5T7XF3Vg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="XRZoHxdBuU2uVygIvpqY2A" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" formula="HKBOfVSvJUiGAeVd6F5BJg" dim="Density" quantityType="0" />
-                <Parameter id="ae9cN8Uq10GNkf9D_O7B4Q" name="Excretion_Time_k2" description="Supporting parameter for calculation of excretion time" persistable="0" isFixedValue="0" formula="Bdpj3NFXfEyjrWArpZBWGg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="ug_mgytRQ0SMxFSaj_Fiow" name="Excretion_Time_k1" description="Supporting parameter for calculation of excretion time" persistable="0" isFixedValue="0" formula="WcLek7_jDkOFkQsuUnrKNg" dim="Time" quantityType="0" />
-                <Parameter id="x3IvOWxUe0muCHKprHqr9Q" name="Excretion_Time_k0" description="Supporting parameter for calculation of excretion time" persistable="0" isFixedValue="0" formula="OrbMozi28EGQF7yjdR6ZPw" dim="Time" quantityType="0" />
-                <Parameter id="KPR_Y-8NAU-G2CTVmApsmw" name="Excretion time" description="Excretion time" persistable="0" isFixedValue="0" formula="OMuPohGWo0-VQ3NEJzydQA" dim="Time" quantityType="0" />
-                <Parameter id="g2fd03vOmEmZ0PWI5UToKg" name="Mucosa blood flow fraction" description="Blood fraction which goes to mucosa" persistable="0" isFixedValue="0" formula="JHF_Q_k5HE6K8E0Eux9_dA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="3ccgRojTcEqacgGVkT5ZaQ" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" formula="YG9ulRIY4EWEBo2mF3Ygyg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="V19XEHMnFUeREs_VvjanKA" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" formula="lu06AINFeEyqMoRPwrKKsw" dim="Nanolength" quantityType="0" />
-                <Parameter id="UTyxuu3Y0UC6Uvbh7Mx2ew" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" formula="vzJKGD2vOk2I-9AQ5IYSNA" dim="Nanolength" quantityType="0" />
-                <Parameter id="ZavmS7xF9U-BG35uKhn0Fg" name="Lymph flow rate (incl. mucosa)" description="Lymph flow rate (incl. mucosa)" persistable="0" isFixedValue="0" formula="FbjVxTn8DECZSZtdiQe9sw" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="RKVulbw9NUic0n120n9V9w" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" formula="JPIyITCi_0GQlO6s1S0VtQ" dim="HydraulicConductivity" quantityType="0" />
-                <Parameter id="PUvlGXx22keIPQsJ4OW1ZA" name="Fluid recirculation flow rate (incl. mucosa)" description="Fluid recirculation flow rate between plasma and interstitial space (incl. mucosa)" persistable="0" isFixedValue="0" formula="xmCg4TGh40yoH8lt4mQPsQ" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="dmBSDMcbTUu0zWA1roEemg" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" formula="Is05A2AhskaY5HhtgkvBHg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="k3BRwBSm0Eud5h1SHu1Qvg" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="3i5UffYu_kupZt7jMZboaQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="5s9Jrihzzk-PsP1mQDgszQ" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="QPjs3JlwxEehpLGIlVuuqg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="W-KWILjYh0a84s70wD9uYA" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" formula="P0taiJ38REi-EJ6p8y1cqg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="mJgmmaki4EixNTJHmAOA9Q" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="VgT9KZSFrU26UarPwSmaRQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="aWcOiUx51Ue5v--eXX12BA" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="1a3hPsB6V0eIIWr5te1SYQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="Zzvq9SyXb0-C6f8nVP1qdw" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="pBCoYiJUjUeDEo_Ik7rs-Q" dim="Dimensionless" quantityType="0" />
-                <Parameter id="nwQDtG5-EE2Bvcntc21jhw" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="EacYyQb6CEyPU9V14pjk0Q" dim="Dimensionless" quantityType="0" />
-                <Parameter id="EbBeFLUQ4EyCz3_9QTOdzg" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="FSVkIAO-oEuBtnXo1TLaAg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="mt9aeqyhhUivkWJxnvilqQ" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="REdVBumI20OS-p5DUJhXbg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="Ys8B8p1bcUCqnpBHTE9d3A" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="a2IJ7oKbtE-5bdYh1Q5Y_Q" dim="Dimensionless" quantityType="0" />
-                <Parameter id="H30gJaTaJUSmb96b5tPUHQ" name="Protein mass/g tissue" description="Total protein content per gram tissue" persistable="0" isFixedValue="0" formula="F2lLKut_s0mMgjP7nKUHlA" dim="MassProteinPerTissue" quantityType="0" />
-                <Parameter id="LSxqlrIKmE6lY2s4LPKgqA" name="Microsomal protein mass/g tissue" description="Microsomal protein content per gram tissue" persistable="0" isFixedValue="0" formula="A29K2ln_ZkKk2Qwdj3mgxg" dim="MassProteinPerTissue" quantityType="0" />
-                <Parameter id="kafZWIcq80-SCMgZdgRqIA" name="Number of cells/g tissue" description="Number of cells per gram tissue" persistable="0" isFixedValue="0" formula="l9XqMDvm9USEuHflSEIcFg" dim="CellQuantityPerTissue" quantityType="0" />
-                <Parameter id="iUCcu0ZZjEKNjx18GyDY3g" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" formula="HYXfOnT2rUu5g8oecZzEdg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="JNk6IzGbgU-dBY6xmBnf7Q" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="xsuxMUM6SUOHr2GCSEdGgQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="H5wacJC7hUegemUaj65V-Q" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="imJO2DFHQ0GVDsotmsLTAw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="pyPv9QTO9UWhXn0ZKVokyQ" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="iDELppKyB0WJ3R4lDHLhCQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="plp_fWvoZ0KE7YvKLUh7IQ" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="9XQs2-fLIU-MEWGzKOuBIg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="_1jGrNieKUWonpWZ5-cW-g" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="V8DLiZVDm0urgsrNf6bWdw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="DlIhag1jx0WhfmKtAjoMMw" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="50ji1CjpAEOEpxjsqfcEqA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="EsUBLtsrlE6C6XFUuAJjlA" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="l9lKU6215EWZ_KtMpOBhbw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="LUN0RCyBJkmbo76de3nN7w" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="wKfb1ahbGkG93dw2eRFoSA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="pX7q4cfZ-ECeeUWSb5y6Sg" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="N3d5Q6lcSkecEsl8zzcKgw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="nhI6XY4l1UGivBXfqcb7Hw" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="Tb87uJSlJE64dyIm2p3sQw" dim="Dimensionless" quantityType="0" />
-                <DistributedParameter id="jIOY4Ub5r0mVlA8F1sIzCg" name="Volume" description="Volume of organ or compartment" persistable="1" isFixedValue="0" formula="RrF92TtFy0axoUdu8yXSmg" dim="Volume" quantityType="0" mode="Logical">
-                  <Children>
-                    <Parameter id="0EUB3V5gvU6nqfIB858UUw" name="Percentile" persistable="0" isFixedValue="0" formula="MKVJbJa6hUWnY_CP5_Ltag" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="whzHaAnaFkCpGNmqOOcLsQ" name="Mean" persistable="0" isFixedValue="0" formula="fAyxUmVS80yC_UD1NraTNQ" dim="Volume" quantityType="0" />
-                    <Parameter id="V38t5n7gSUa0kwrowGsyAw" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" formula="dfsxIrJrI0m9sz0p2cxJ2Q" dim="Volume" quantityType="0" />
-                  </Children>
-                </DistributedParameter>
-                <DistributedParameter id="kfSsipLPw0S1wj_0B0jnQg" name="Specific blood flow rate" description="Blood flow rate normalized to the organ volume" persistable="1" isFixedValue="0" formula="Tkt-nTbNWk6GUVCFGo2HdA" dim="Flow (volume) per organ weight" quantityType="0" mode="Logical">
-                  <Children>
-                    <Parameter id="cM42wo7wfUeKdE2dWZQvrQ" name="Percentile" persistable="0" isFixedValue="0" formula="L-_IOuOWtkmEiu5Vz_TnJw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="XoKXZxgE90m2MfRI39r-eg" name="Mean" persistable="0" isFixedValue="0" formula="4eW58t_WQEO2Sdz2VrvyEg" dim="Flow (volume) per organ weight" quantityType="0" />
-                    <Parameter id="S-udVO-izUOybhaDR5IsBw" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" formula="5_d8k0YRvUCkci_DZOQSyA" dim="Flow (volume) per organ weight" quantityType="0" />
-                  </Children>
-                </DistributedParameter>
-                <Container id="kX3NLMXH5kGsPE4c_l2A7A" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Plasma" />
-                    <Tag value="LargeIntestine" />
-                    <Tag value="Portal Vein Supplying Organ" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="POVJJxPCeEaleDc74FGNrA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="owgI66XQcE2ClB4BHV50ew" dim="Volume" quantityType="0" />
-                    <Parameter id="Jh2YIoJlCkGxr_Ni3x-l7Q" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="yOdsFdfvgU-9h2LWnUPLRw" dim="Volume" quantityType="0" />
-                    <MoleculeAmount id="CeR0DerUEk6Aqx58R2Mk4Q" name="Drug" icon="Drug" persistable="0" isFixedValue="0" formula="9pWFhIXyxEG9AsaTo6-iig" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="JzBrVEUrM0C5bSuHZ6ipig" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Parameter id="lzkZbyA370inYTSnO5FyNQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="pNhuCXLKZkyTjybXXSK2Tw" dim="Dimensionless" quantityType="0" />
-                        <Observer id="qP9nQ8_l1EmiIM-NZsBsLw" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Drug, Observer" />
-                      </Children>
-                    </MoleculeAmount>
-                    <MoleculeAmount id="7OEyflYQPUKpWg9L7BTjpw" name="Cyp" icon="Enzyme" persistable="0" isFixedValue="0" formula="wb5yCXJZxUeVY_7iSBmoSg" dim="Amount" quantityType="Enzyme" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="b89FvDSPLkKJ1S2_2f6t8A" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" formula="rzuIusrH3EC28CJgWr2LMQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="93Hnhod9_UaFIXt_s1UIIA" name="Relative expression out." description="Relative Expression that will be used in the simulation" persistable="0" isFixedValue="0" formula="GtBZCb_uvUKgURPKDkyZKA" dim="Fraction" quantityType="0" />
-                        <Parameter id="cB_sXaGgmUihfKYOoM9fXw" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" persistable="0" isFixedValue="0" formula="Qv2OyMi-nU-kPqJ48WVuVw" dim="Fraction" quantityType="0" />
-                        <Parameter id="QeT1cx3dKU6jgEVTiYqQPg" name="Relative expression" description="Relative expression" persistable="0" isFixedValue="0" formula="iUzjEbj_NkSh4u8TNBhFgQ" dim="Fraction" quantityType="0" />
-                        <Parameter id="qV5WuKEbbkuqlOff_a-BQw" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Observer id="bg2rf2uZq0yCyraOqDP0XA" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Enzyme, Observer" />
-                      </Children>
-                    </MoleculeAmount>
-                    <MoleculeAmount id="-19cD8WEfEeEba-kYQuUUQ" name="Drug-Cyp Metabolite" persistable="0" isFixedValue="0" formula="4OL6j6Lr2kGy1kdjStu_yg" dim="Amount" quantityType="Metabolite" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="u2C6XS5bgEmvMVGfUynaJQ" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Observer id="2R0riOLojkyk2WsFjukWUQ" name="Fraction of dose" description="Metabolized fraction of administered dose" persistable="1" isFixedValue="0" formula="aUoTQ3n3a0OShljd8bUj3w" dim="Fraction" quantityType="Metabolite, Observer" />
-                      </Children>
-                    </MoleculeAmount>
-                    <Reaction id="U8ZwMHgUzUS3vPNZD6_feg" name="Cyp-ME" icon="Metabolism" mode="Logical" containerType="Other" dimension="Dimensionless" formula="NrKgrsKmwkiGET1q7OIPYg">
-                      <Educts>
-                        <ReactionPartner stoichiometricCoefficient="1" partner="CeR0DerUEk6Aqx58R2Mk4Q" />
-                      </Educts>
-                      <Products>
-                        <ReactionPartner stoichiometricCoefficient="1" partner="-19cD8WEfEeEba-kYQuUUQ" />
-                      </Products>
-                      <ModifierNames>
-                        <ModifierNamesChild>Cyp</ModifierNamesChild>
-                      </ModifierNames>
-                    </Reaction>
-                  </Children>
-                </Container>
-                <Container id="wMP3kbtQaUKQg4QfYQVYGg" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="BloodCells" />
-                    <Tag value="LargeIntestine" />
-                    <Tag value="Portal Vein Supplying Organ" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="_cp3jr_In0WhNZzKjrbyTg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="owgI66XQcE2ClB4BHV50ew" dim="Volume" quantityType="0" />
-                    <Parameter id="ytEUodp1k0S0c9KaY7TwzA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="uN7qjO_jDkyLOIbLKq8Agw" dim="Volume" quantityType="0" />
-                    <MoleculeAmount id="BbZT4ZKz3ES0AnolBdIDWw" name="Drug" icon="Drug" persistable="0" isFixedValue="0" formula="i97VmNEgdUag1WjpkqLWoA" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="_0RS-MSJakqUb0bqDDj06g" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Parameter id="frdqDgPqbU2Mgx4MbrZ63g" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="pIcV9M8nJ02kgfMqxFZ3AA" dim="Dimensionless" quantityType="0" />
-                        <Observer id="WqRYP27uIUG2Y-oy8aBXiA" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Drug, Observer" />
-                      </Children>
-                    </MoleculeAmount>
-                    <MoleculeAmount id="8b1VcXO0ckqaOebsCPxGMA" name="Cyp" icon="Enzyme" persistable="0" isFixedValue="0" formula="wb5yCXJZxUeVY_7iSBmoSg" dim="Amount" quantityType="Enzyme" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="tF4vTS5luE6yhGoItmYTCQ" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" formula="iyqpiDGPjkmjCVObSKX7PQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="nqR_B7rqR061fExQIj3eZw" name="Relative expression out." description="Relative Expression that will be used in the simulation" persistable="0" isFixedValue="0" formula="GtBZCb_uvUKgURPKDkyZKA" dim="Fraction" quantityType="0" />
-                        <Parameter id="nyVhTl9mAEig6UdXSh0cBw" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" persistable="0" isFixedValue="0" formula="FTxLv_b4CkKigLwWdcA4xg" dim="Fraction" quantityType="0" />
-                        <Parameter id="nyJhWgz7rEq8RTvFokE6fg" name="Relative expression" description="Relative expression" persistable="0" isFixedValue="0" formula="_J3C13ewoUatoCS2w-zxeg" dim="Fraction" quantityType="0" />
-                        <Parameter id="cESRWL0VBUO1hqc_mYsB5g" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
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-                    <MoleculeAmount id="1ODp8gfcO0OMPa5KTcqMwA" name="Drug-Cyp Metabolite" persistable="0" isFixedValue="0" formula="QTeAIsdTc0WHd5DZawqrHQ" dim="Amount" quantityType="Metabolite" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="Kx6prhCCzUG26BPQUH5Dyw" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Observer id="4z0yfWDjX0GXkHQCwSdNmw" name="Fraction of dose" description="Metabolized fraction of administered dose" persistable="1" isFixedValue="0" formula="aUoTQ3n3a0OShljd8bUj3w" dim="Fraction" quantityType="Metabolite, Observer" />
-                      </Children>
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-                    <Reaction id="CpRvOBNvHECrCdaCGlrsPw" name="Cyp-ME" icon="Metabolism" mode="Logical" containerType="Other" dimension="Dimensionless" formula="NrKgrsKmwkiGET1q7OIPYg">
-                      <Educts>
-                        <ReactionPartner stoichiometricCoefficient="1" partner="BbZT4ZKz3ES0AnolBdIDWw" />
-                      </Educts>
-                      <Products>
-                        <ReactionPartner stoichiometricCoefficient="1" partner="1ODp8gfcO0OMPa5KTcqMwA" />
-                      </Products>
-                      <ModifierNames>
-                        <ModifierNamesChild>Cyp</ModifierNamesChild>
-                      </ModifierNames>
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-                </Container>
-                <Container id="0MSX5zYlDUGmNmmRt_-66g" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Interstitial" />
-                    <Tag value="LargeIntestine" />
-                    <Tag value="Portal Vein Supplying Organ" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="JvMV-MNbXU2tDk8e03JG2w" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="owgI66XQcE2ClB4BHV50ew" dim="Volume" quantityType="0" />
-                    <Parameter id="3ixQUAeVTkOn0uJrBIzeTw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="6t_qjRTVS0KXJ3KXjkxBqQ" dim="Volume" quantityType="0" />
-                    <Parameter id="mue2LYtLdk6Kj6FyQh7R5Q" name="pH" description="pH" persistable="0" isFixedValue="0" formula="tKjHIxsi60KoHEPhXQBZrw" dim="Dimensionless" quantityType="0" />
-                    <MoleculeAmount id="xfE-lNQYs0u0uNUT0IDWdw" name="Drug" icon="Drug" persistable="0" isFixedValue="0" formula="T-1YABGqKk6TnOWN3Hfbjg" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="ghd_wyI29kWuDeOtHw9iKw" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Parameter id="RY12nXaxD0WmfYSRGSwB4Q" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="VL5EXNN8s02HxTWGrR2k5Q" dim="Dimensionless" quantityType="0" />
-                        <Observer id="nTiVaHVkj0WbPd2Jm1rJ1g" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Drug, Observer" />
-                      </Children>
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-                </Container>
-                <Container id="iYxcQ6cTuUi76OZcQHLbbg" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Intracellular" />
-                    <Tag value="LargeIntestine" />
-                    <Tag value="Portal Vein Supplying Organ" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="H7ULGnfP4kOYQfOKXF5Ttg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="eesOXd058064pnhhYx8nCg" dim="Volume" quantityType="0" />
-                    <Parameter id="aXcEHWZTvk6emdXdUkY_OQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="xwF6rFcp20ODTx-ji_f8qA" dim="Volume" quantityType="0" />
-                    <Parameter id="H_RdZwRHpU-6CRml2Vg9rg" name="pH" description="pH" persistable="0" isFixedValue="0" formula="WhcYWMHb1UaktP0ioWATrg" dim="Dimensionless" quantityType="0" />
-                    <MoleculeAmount id="I4gd3Pd1HUGgZcAEqBNrkw" name="Drug" icon="Drug" persistable="0" isFixedValue="0" formula="uVNBFqpbNUazThNWDcZhWA" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="meaQCRvPkUK6Aude4bKdxA" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Parameter id="Ih5O8eQyoUePCddzZhfClA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="F5-occe94UCcvg3M4Q6uXw" dim="Dimensionless" quantityType="0" />
-                        <Observer id="Ncn6z1uAzkWHLkLNqdxAnQ" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Drug, Observer" />
-                      </Children>
-                    </MoleculeAmount>
-                    <MoleculeAmount id="ABrwud24d0WyBxA-NOkSXw" name="Cyp" icon="Enzyme" persistable="0" isFixedValue="0" formula="wb5yCXJZxUeVY_7iSBmoSg" dim="Amount" quantityType="Enzyme" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="96VW4Um66kicXCPRn2L2RA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" formula="oYth9iFn00Kv7NTQbeZ6MQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="Hp68-BnHt0C7LZ8e1xSncw" name="Relative expression out." description="Relative Expression that will be used in the simulation" persistable="0" isFixedValue="0" formula="GtBZCb_uvUKgURPKDkyZKA" dim="Fraction" quantityType="0" />
-                        <Parameter id="4ziv4KLHv0WpcIyNfnpVEg" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" persistable="0" isFixedValue="0" formula="WDa1xtFpSUu-YUhP4sKBPw" dim="Fraction" quantityType="0" />
-                        <Parameter id="W71FfvFBNEquDUrFrJme9Q" name="Relative expression" description="Relative expression" persistable="0" isFixedValue="0" formula="YOwVNVvI2USpbdElfrqIig" dim="Fraction" quantityType="0" />
-                        <Parameter id="Zd_Oeg29rEqjpcybozTvmg" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Observer id="r913JVeS3U-Wo0y5MF1IJQ" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Enzyme, Observer" />
-                      </Children>
-                    </MoleculeAmount>
-                    <MoleculeAmount id="ApbS24_MMUSTbR4EjaabiQ" name="Drug-Cyp Metabolite" persistable="0" isFixedValue="0" formula="RYDb1_3D4UCmZxqO-gJISA" dim="Amount" quantityType="Metabolite" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="0FMwbyQvlUWwPCY2mD4LZA" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Observer id="qAx_6iDIFkCddO-GTecymQ" name="Fraction of dose" description="Metabolized fraction of administered dose" persistable="1" isFixedValue="0" formula="aUoTQ3n3a0OShljd8bUj3w" dim="Fraction" quantityType="Metabolite, Observer" />
-                      </Children>
-                    </MoleculeAmount>
-                    <Reaction id="-pcqwt2UmkahxxPPX_0X7w" name="Cyp-ME" icon="Metabolism" mode="Logical" containerType="Other" dimension="Dimensionless" formula="NrKgrsKmwkiGET1q7OIPYg">
-                      <Educts>
-                        <ReactionPartner stoichiometricCoefficient="1" partner="I4gd3Pd1HUGgZcAEqBNrkw" />
-                      </Educts>
-                      <Products>
-                        <ReactionPartner stoichiometricCoefficient="1" partner="ApbS24_MMUSTbR4EjaabiQ" />
-                      </Products>
-                      <ModifierNames>
-                        <ModifierNamesChild>Cyp</ModifierNamesChild>
-                      </ModifierNames>
-                    </Reaction>
-                  </Children>
-                </Container>
-                <Container id="5TcLmVm2v0qir8xcG9OV9Q" name="Mucosa" description="Mucosa" mode="Logical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Mucosa" />
-                  </Tags>
-                  <Children>
-                    <Container id="BYd3Dj-8VkOq99hqRa0mmQ" name="Caecum" description="Cecum" icon="Caecum" mode="Logical" containerType="Compartment">
-                      <Tags>
-                        <Tag value="Caecum" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="JuQaF8fmX0qaW12Z2Z8_HQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="iUt6VaVpSkquqNmn8V7r4w" dim="Volume" quantityType="0" />
-                        <Parameter id="-t6oHM8rIU6v4DKxlof1BA" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" formula="6e9LHlTFJkG-PMFyieazhw" dim="Flow (volume)" quantityType="0" />
-                        <Parameter id="pKxV4_ZghUW7TdR10ejuOg" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" formula="hB48fjDKB0aPhnPyDobY9g" dim="Flow (volume)" quantityType="0" />
-                        <Parameter id="q6waeCvF0UiEK5myG_4CZw" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" formula="H8bUllkvF02PgOGPI8hxQA" dim="Volume" quantityType="0" />
-                        <Parameter id="e748FnLGJ0-kIunoEWitIg" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" formula="PSbm5ReMbUKRj9xRJC3ccA" dim="Flow (volume)" quantityType="0" />
-                        <Parameter id="jPX28NP0fkG-BJxibZ5bAQ" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" formula="FbGzbaLst0K5o2gc_gSjaQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="UvEck-2Kik2G6eHqgkE3nQ" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" formula="G60_MnwIEEyZSaE3DUph6A" dim="Density" quantityType="0" />
-                        <Parameter id="QtzoQcnFg0So_tO8T4vbZQ" name="Fraction of regional blood flow rate" description="Regional blood flow fraction supplying the mucosal tissue of the segment" persistable="0" isFixedValue="0" formula="DRvi4BD9jUmLeGFzCIm97A" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="uX6Z2aZo5keH-CXIVWDFBQ" name="Fraction mucosa" description="Mucosal fraction of regional intestinal tissue mass" persistable="0" isFixedValue="0" formula="1-KPked_MUO1l7lnuV2Btw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="UtdIbS9JzkyGALiGDdx3eA" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" formula="yRJMVsBUHk-D4r6Co4_G_g" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="SeMnNKDl906sTkbgaHLKcQ" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" formula="MRmyggXWr0ifshTDwnHP7A" dim="Nanolength" quantityType="0" />
-                        <Parameter id="58fxKjHEBkaO0jzE65mdbA" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" formula="0YjLrdhesU-POqcuLICXyQ" dim="Nanolength" quantityType="0" />
-                        <Parameter id="ACjXN6UnXkeaPvitvfetKg" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" formula="GgVcyo0QOECneLyd3vNujw" dim="HydraulicConductivity" quantityType="0" />
-                        <Parameter id="WsQStD_YUk-hBcM1CnU-eA" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" formula="-dUr6z3C2UavLYVOQLioOw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="UyhuUIwrPkS9xAF0fFtcKg" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="p5q7e6A41kC1OWFW6NUmjQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="dD6M65WHs0qyPPHTuWIncg" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="5Qf2QuSBIEWuoypGkSn3gQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="ATTZ-VtayEKrTlG9Wmyt0A" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" formula="8W0dC3X33UecdpYW9YMZcg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="C8cPz7tQ5km5LbIgOj5saw" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="MMkvV73H1UeaZ4SPU6iJ-Q" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="R1K-c8yaBkGjEi12VDjXWw" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="Z4lR6u4hjE-4uIFMkhsbjA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="WkZGu-CpH0iZpXh4KJrdcg" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="OMfWsthDg0Sq6sXEycqwLQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="C5eplQQRl0Gn6gC950Xrww" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="ATB63pWfoUuKB21FhnGfTQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="3HizMPA4dUeBZ1zbuDLa_w" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="nMMBc4YD30SuRu6mXdkgNA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="FIK09bidlE-p23D7DhE-dA" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="pjfuDUOL8Eaobj_ZqJIY2w" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="SskzFFcTJkmelquzNF0hyw" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="9OW2VxGXFEaDbDV0aN0j7A" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="aAJiFd5MhEisImkOzYMT6Q" name="Microsomal protein mass/g tissue" description="Microsomal protein content per gram tissue" persistable="0" isFixedValue="0" formula="jP2Zdh1x4kC-k41xcpKQaQ" dim="MassProteinPerTissue" quantityType="0" />
-                        <Parameter id="By8spjxkFUKQwPgewEoMfg" name="Number of cells/g tissue" description="Number of cells per gram tissue" persistable="0" isFixedValue="0" formula="7sAV6iZ_Ikynp0riSp-00A" dim="CellQuantityPerTissue" quantityType="0" />
-                        <Parameter id="xgsJXbyAHUy8NzY70P5utQ" name="Protein mass/g tissue" description="Total protein content per gram tissue" persistable="0" isFixedValue="0" formula="sDqkS3mbD0mwFtWKt3GchA" dim="MassProteinPerTissue" quantityType="0" />
-                        <Parameter id="Gp-KgVUPmEOelJCQlBFJ5A" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" formula="WV8Hg3xRTk6hsAQvH1TicQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="h9BT_YtA9k6z2IUDYN5Yqw" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="eEvuGTZ1zEyKdH-UCymd2g" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="8MIZjiwGFEiXdwnh7uVKGg" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="TACka5N49UCjLMgIlxZQJA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="PxSg7F0mkUuo2dfLiI8Yzg" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="XUjsyTI1e0i2Ir-99IRTaA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="sIg8ZqcBvEGs-cDYKd1XyQ" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="yaIYiX1uF0KNQF8PiLCjfQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="8x_K12wCCUCmiCqQubqk3A" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="sjddsdplTUKDnMcz-ux95A" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="ivVqRXa8n0WGB1wvwJXSzQ" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="i-8GDow6h0utz28ZkcIXCw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="Bs4j7-2M6ECk4AbxnV2ogA" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="5bqRKXazhEukAe05FB9HlA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="XUf03e_7x0-jYvBLarwzHQ" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="3vnK0f5FA0ubHtYwmN2DTQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="gEFvfYVjsUCudw3Va336Dg" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="gXKY23eVAkCJrQjnp4wAwQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="e9OX1fd1FECSMMbiMvqH6A" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="HM6kpNMl5Eys3niQkXkJ-w" dim="Dimensionless" quantityType="0" />
-                        <Container id="l8icBJ2uN0KH4u_hLlRE-Q" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Plasma" />
-                            <Tag value="Caecum" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="oSPZV7Y9mUSnejSbE1DJdQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="owgI66XQcE2ClB4BHV50ew" dim="Volume" quantityType="0" />
-                            <Parameter id="z41AqrRFp0imdcf5npnPOg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="rbp4e7PXpUyuD1ZtA8Ocxw" dim="Volume" quantityType="0" />
-                            <MoleculeAmount id="0BQVZSFbd0yvGdZJo-TkmQ" name="Drug" icon="Drug" persistable="0" isFixedValue="0" formula="p-pTLhHaU0WzG_GgWPOW_g" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="L75xxVsBGUeCaF4bQIxG8A" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Parameter id="FvZ2_ntLpUSkqxYW4JUIgA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="zDzFB2dyCUKgAEmBeZgfJg" dim="Dimensionless" quantityType="0" />
-                                <Observer id="5ziYeffaKk2vsfalBcGDvA" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Drug, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                            <MoleculeAmount id="mHg622AuZkqZJtuDX4z1eA" name="Cyp" icon="Enzyme" persistable="0" isFixedValue="0" formula="wb5yCXJZxUeVY_7iSBmoSg" dim="Amount" quantityType="Enzyme" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="2PG-cfJCC027VL7xsW3gmw" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" formula="GDhuDdFdPUq-n3T7ApQOMA" dim="Dimensionless" quantityType="0" />
-                                <Parameter id="10RLXQr13k6bDJbUgVZ3hw" name="Relative expression out." description="Relative Expression that will be used in the simulation" persistable="0" isFixedValue="0" formula="GtBZCb_uvUKgURPKDkyZKA" dim="Fraction" quantityType="0" />
-                                <Parameter id="FAtJgSUULUeGCq7_iAQf5A" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" persistable="0" isFixedValue="0" formula="Qv2OyMi-nU-kPqJ48WVuVw" dim="Fraction" quantityType="0" />
-                                <Parameter id="aSTx7Zz-Fk-GSBGCDF3IhQ" name="Relative expression" description="Relative expression" persistable="0" isFixedValue="0" formula="iUzjEbj_NkSh4u8TNBhFgQ" dim="Fraction" quantityType="0" />
-                                <Parameter id="kzbS3I_GA0Wf5ehFqWZAjQ" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Observer id="7nYqIU9g902OFkgB_uZXNA" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Enzyme, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                            <MoleculeAmount id="KJbnEiozeECreTDB45eLMg" name="Drug-Cyp Metabolite" persistable="0" isFixedValue="0" formula="-N2CPthPtEum4HtZDMnHcw" dim="Amount" quantityType="Metabolite" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="DsU-diU0jES4k0yJfhNxxA" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Observer id="rN_bdV4IfE6xfWK2ufTYUQ" name="Fraction of dose" description="Metabolized fraction of administered dose" persistable="1" isFixedValue="0" formula="aUoTQ3n3a0OShljd8bUj3w" dim="Fraction" quantityType="Metabolite, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                            <Reaction id="v2JBeH2aakeOcJRfIAtIng" name="Cyp-ME" icon="Metabolism" mode="Logical" containerType="Other" dimension="Dimensionless" formula="NrKgrsKmwkiGET1q7OIPYg">
-                              <Educts>
-                                <ReactionPartner stoichiometricCoefficient="1" partner="0BQVZSFbd0yvGdZJo-TkmQ" />
-                              </Educts>
-                              <Products>
-                                <ReactionPartner stoichiometricCoefficient="1" partner="KJbnEiozeECreTDB45eLMg" />
-                              </Products>
-                              <ModifierNames>
-                                <ModifierNamesChild>Cyp</ModifierNamesChild>
-                              </ModifierNames>
-                            </Reaction>
-                          </Children>
-                        </Container>
-                        <Container id="z3nIn6C3j0yVWC-W8t3Ztg" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="BloodCells" />
-                            <Tag value="Caecum" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="YsHEuI66ykWN-i-kWAVUUg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="owgI66XQcE2ClB4BHV50ew" dim="Volume" quantityType="0" />
-                            <Parameter id="MHcdKk4CPUm_4Gizgfdohw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="tFZiRJ-Sv0qf0gsV7ycmYw" dim="Volume" quantityType="0" />
-                            <MoleculeAmount id="Bdz3BSeKVE6ApvHc1Oikmg" name="Drug" icon="Drug" persistable="0" isFixedValue="0" formula="9WNxaxKOPkiZmnpbuXAp8Q" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="olfINuojDE2q9Q8vm2jn0Q" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Parameter id="kWbRvZVp00mVm0688X1yGQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="YZnodPT4vkGcUHDhE97cAw" dim="Dimensionless" quantityType="0" />
-                                <Observer id="sZ0kTveKykiutIgHR9rhgA" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Drug, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                            <MoleculeAmount id="bNBkHQTkkEy2J7r_UJ7-WA" name="Cyp" icon="Enzyme" persistable="0" isFixedValue="0" formula="wb5yCXJZxUeVY_7iSBmoSg" dim="Amount" quantityType="Enzyme" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="GsuViIB6ek6MpiV4q3TdvQ" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" formula="5hWk_Hwt8kCd1IES5Mr6mw" dim="Dimensionless" quantityType="0" />
-                                <Parameter id="xaUwWs_PmES-xpxJ54Qv1Q" name="Relative expression out." description="Relative Expression that will be used in the simulation" persistable="0" isFixedValue="0" formula="GtBZCb_uvUKgURPKDkyZKA" dim="Fraction" quantityType="0" />
-                                <Parameter id="SPdEtyJmh0qC_xE56tssCg" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" persistable="0" isFixedValue="0" formula="FTxLv_b4CkKigLwWdcA4xg" dim="Fraction" quantityType="0" />
-                                <Parameter id="tM0VewotEkGyaevA_TJvjA" name="Relative expression" description="Relative expression" persistable="0" isFixedValue="0" formula="_J3C13ewoUatoCS2w-zxeg" dim="Fraction" quantityType="0" />
-                                <Parameter id="8_G5pTEqvECPVSfjpv1qVw" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Observer id="Qax3-9xxf06Y3nZ3LwLtQw" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Enzyme, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                            <MoleculeAmount id="uNOkD27J4kWe9sNZpuIU0A" name="Drug-Cyp Metabolite" persistable="0" isFixedValue="0" formula="xh_PT7Hx7UGlFgIoKQJp3Q" dim="Amount" quantityType="Metabolite" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="wHE58XRQJU2Jphv5FGFN3Q" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Observer id="onZISS2JCEG_xmCaPTY4wg" name="Fraction of dose" description="Metabolized fraction of administered dose" persistable="1" isFixedValue="0" formula="aUoTQ3n3a0OShljd8bUj3w" dim="Fraction" quantityType="Metabolite, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                            <Reaction id="GaJ6YVAWdkiSLv3UHMYUlw" name="Cyp-ME" icon="Metabolism" mode="Logical" containerType="Other" dimension="Dimensionless" formula="NrKgrsKmwkiGET1q7OIPYg">
-                              <Educts>
-                                <ReactionPartner stoichiometricCoefficient="1" partner="Bdz3BSeKVE6ApvHc1Oikmg" />
-                              </Educts>
-                              <Products>
-                                <ReactionPartner stoichiometricCoefficient="1" partner="uNOkD27J4kWe9sNZpuIU0A" />
-                              </Products>
-                              <ModifierNames>
-                                <ModifierNamesChild>Cyp</ModifierNamesChild>
-                              </ModifierNames>
-                            </Reaction>
-                          </Children>
-                        </Container>
-                        <Container id="XQ9QHp4bX0ieSHXh2FVHVw" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Interstitial" />
-                            <Tag value="Caecum" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="-BF7Ll-SqEyqrDDDRCbXYQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="owgI66XQcE2ClB4BHV50ew" dim="Volume" quantityType="0" />
-                            <Parameter id="7U57H2hTfUuDzEfETFNPiw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="4VSppd3W3E6-12kllCJ0Mg" dim="Volume" quantityType="0" />
-                            <Parameter id="C4EGmB01fUeSQSvisJPgAg" name="pH" description="pH" persistable="0" isFixedValue="0" formula="tKjHIxsi60KoHEPhXQBZrw" dim="Dimensionless" quantityType="0" />
-                            <MoleculeAmount id="l5UJjzesd0aVZxrz4twDag" name="Drug" icon="Drug" persistable="0" isFixedValue="0" formula="JishOTM_TUWtM0PrUByvFw" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="WE4EuGZ74k2BP-mzrLCYFg" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Parameter id="daudcYiqPUq4iy6z7RRGqQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="k1Gk0rEveEqAynnyZpsjDQ" dim="Dimensionless" quantityType="0" />
-                                <Observer id="0vKMo7YFVUSZn-feQ7XxYg" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Drug, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                          </Children>
-                        </Container>
-                        <Container id="owoyJrHWdkm0XLbwyDZ8rQ" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Intracellular" />
-                            <Tag value="Caecum" />
-                            <Tag value="IntestinalSecretionSource" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="w4OSCGjugUCuZ6h-N5OHfg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="M9arQg_qfEGMA7JdlSXkFA" dim="Volume" quantityType="0" />
-                            <Parameter id="7TBuOyR8y0OtHXzKBcyA9g" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="3l84whkuX0S7xUUHglUQpg" dim="Volume" quantityType="0" />
-                            <Parameter id="p0q02W5UdkW7OS1efhPfgw" name="pH" description="pH" persistable="0" isFixedValue="0" formula="qCSeMdvzT0CrhEUuVNOJKw" dim="Dimensionless" quantityType="0" />
-                            <MoleculeAmount id="wCOP5C6iSUaesCPdCtMtCg" name="Drug" icon="Drug" persistable="0" isFixedValue="0" formula="UlTG5Nb7Okm_8tsr6pccAg" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="3nodhmmY6EuxiJIkiu4pzA" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Parameter id="BWA8HztgakCXjALDSUNGRA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="xGIEc9exwUyx79ofugVB9w" dim="Dimensionless" quantityType="0" />
-                                <Observer id="vAgev8U0BkO0bmWzMMzHKA" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Drug, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                            <MoleculeAmount id="S88_B_WlGkuoreX_LeAQ_w" name="Cyp" icon="Enzyme" persistable="0" isFixedValue="0" formula="wb5yCXJZxUeVY_7iSBmoSg" dim="Amount" quantityType="Enzyme" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="Hdp2rEcyZkWbUAj9yk4_Iw" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" formula="eaSsBbQjEEC1YzYVex1lHw" dim="Dimensionless" quantityType="0" />
-                                <Parameter id="SEzn-ynzBEaOmKx3-CXDZQ" name="Relative expression out." description="Relative Expression that will be used in the simulation" persistable="0" isFixedValue="0" formula="GtBZCb_uvUKgURPKDkyZKA" dim="Fraction" quantityType="0" />
-                                <Parameter id="cLvIbftxdUSJHSVNBuyoXg" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" persistable="0" isFixedValue="0" formula="urvGaqgwmUeOGsDNdQGf_Q" dim="Fraction" quantityType="0" />
-                                <Parameter id="Dsn8CM_V20Wr1OqTUvB64w" name="Relative expression" description="Relative expression" persistable="0" isFixedValue="0" formula="Vlg4KM3DTEyvCJIHuvs8ow" dim="Fraction" quantityType="0" />
-                                <Parameter id="wJjqVrcodESEn0-u0s9-IQ" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Observer id="RqpwxWIvyEKGjw9tnW7i6Q" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Enzyme, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                            <MoleculeAmount id="z-tTiaXX_UeUQ1FuO2CcQw" name="Drug-Cyp Metabolite" persistable="0" isFixedValue="0" formula="Ygz7M-Fp90WFu_tUDSW01w" dim="Amount" quantityType="Metabolite" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="FNugw3H9OEWtsN0YIb9h-g" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Observer id="MSa-UM7R10CjOsBDI22DWA" name="Fraction of dose" description="Metabolized fraction of administered dose" persistable="1" isFixedValue="0" formula="aUoTQ3n3a0OShljd8bUj3w" dim="Fraction" quantityType="Metabolite, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                            <Reaction id="fLDj_778sE2d5aSEbEGLzg" name="Cyp-ME" icon="Metabolism" mode="Logical" containerType="Other" dimension="Dimensionless" formula="NrKgrsKmwkiGET1q7OIPYg">
-                              <Educts>
-                                <ReactionPartner stoichiometricCoefficient="1" partner="wCOP5C6iSUaesCPdCtMtCg" />
-                              </Educts>
-                              <Products>
-                                <ReactionPartner stoichiometricCoefficient="1" partner="z-tTiaXX_UeUQ1FuO2CcQw" />
-                              </Products>
-                              <ModifierNames>
-                                <ModifierNamesChild>Cyp</ModifierNamesChild>
-                              </ModifierNames>
-                            </Reaction>
-                          </Children>
-                        </Container>
-                      </Children>
-                    </Container>
-                    <Container id="AZFdRUNPNUq8qZxcy4ZMmg" name="ColonAscendens" description="Colon Ascendens" icon="ColonAscendens" mode="Logical" containerType="Compartment">
-                      <Tags>
-                        <Tag value="ColonAscendens" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="e8yOFksLTk6WJnCCSwqdDg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="fbZT3topv0ay54jrSR_Huw" dim="Volume" quantityType="0" />
-                        <Parameter id="SQkU543NnEKMWo663mVX-A" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" formula="S8jH0fDWgkWKYmAKY97new" dim="Volume" quantityType="0" />
-                        <Parameter id="Ftpy96caUUSEj-_eoFquvQ" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" formula="hB48fjDKB0aPhnPyDobY9g" dim="Flow (volume)" quantityType="0" />
-                        <Parameter id="BM_9qVq1-0GcqJ4oyTBXlg" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" formula="6e9LHlTFJkG-PMFyieazhw" dim="Flow (volume)" quantityType="0" />
-                        <Parameter id="YwxcvkcMP0KpxZ3m701COg" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" formula="PSbm5ReMbUKRj9xRJC3ccA" dim="Flow (volume)" quantityType="0" />
-                        <Parameter id="_5TNUbakAkyOHc7efjp3kQ" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" formula="FbGzbaLst0K5o2gc_gSjaQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="ftfT5wUvP0axD-079ZhQMg" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" formula="1dsd3EieKky5bBuLOOqnyg" dim="Density" quantityType="0" />
-                        <Parameter id="YWt05HgTi0S2BKl9Wg8jww" name="Fraction of regional blood flow rate" description="Regional blood flow fraction supplying the mucosal tissue of the segment" persistable="0" isFixedValue="0" formula="xh5zgGrMm0Cc40kT9UoHUQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="71JqhIwvtEKTPIsWMNIPxw" name="Fraction mucosa" description="Mucosal fraction of regional intestinal tissue mass" persistable="0" isFixedValue="0" formula="RAOswL9W20uZyu6tLDJAnw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="ft0EyP4TMUWx-sarPJpa2g" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" formula="6D3MTsZ7g0G0mcN8FS0gaw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="Q3wYF47dZ0-Q0v77Bc5AIw" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" formula="FcZTtz9mxUiTUO2DEC6DvA" dim="Nanolength" quantityType="0" />
-                        <Parameter id="KpqjQqBtcUGq1gxjppxY3w" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" formula="_5k1J-TnQU21zsbVqFlYIg" dim="Nanolength" quantityType="0" />
-                        <Parameter id="xR8Wxm5sCUqNGgoc92grCw" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" formula="NazUcPme4Uyy480jL7122A" dim="HydraulicConductivity" quantityType="0" />
-                        <Parameter id="HNMpPR2PfEatbmS_HvmZGg" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" formula="okftlEDtbkOy-LSkZzxamg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="xLwhS9fQ3kSdGArwou96qA" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="SHZqn9N-4UWgljXp0xECCA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="neU_MuEJ-EawJGT1zVgtCQ" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="HsBK7seV70uJWm3exD8e3w" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="7omNnBp_uE61Nmfg2IGWcg" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" formula="kyKI11kqj0ae5ZyX63MaIA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="KrcgC2EI6Ei0AnN8W0m7ag" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="femmk226J0i_aeW03mpbBg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="uD1E7FZbxkGwzOEKccoRpQ" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="Of5WoJqnUkK7eud6glB04A" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="XAhM_IH_AUuYTQH7yo8dAA" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="RXmeUJYCCUCGhSIXKPMcQw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="LSWmLeSYCU-uGv80GzN_Rw" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="l1lKtSgq5UeKtQnuXl1g9g" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="YeOJmuJ0Wk2RvDC3u_3CjQ" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="863d9NWW20a710GTNfDfSA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="ecaoSzWkcECPsugO0AJB6g" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="cjfkn-tNKUmZFOv-w66fXQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="i1YrwrvkDkqY_NpUnw02Tw" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="_OLgOFeFM0unV8lpjV18uQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="yqGCiiKknUOgWwOl05jxvw" name="Microsomal protein mass/g tissue" description="Microsomal protein content per gram tissue" persistable="0" isFixedValue="0" formula="jBxblvAIVkWbBUpLS_W45Q" dim="MassProteinPerTissue" quantityType="0" />
-                        <Parameter id="GUXtQ9XLOkOmgoQyR5g4hQ" name="Protein mass/g tissue" description="Total protein content per gram tissue" persistable="0" isFixedValue="0" formula="R4Npft_pgkyDGnjqM0fLkQ" dim="MassProteinPerTissue" quantityType="0" />
-                        <Parameter id="zuarC1seaEOg6EKGoMwL9A" name="Number of cells/g tissue" description="Number of cells per gram tissue" persistable="0" isFixedValue="0" formula="1MoqoQfuRE2oE8289meR8Q" dim="CellQuantityPerTissue" quantityType="0" />
-                        <Parameter id="HggRbG8IZ0mlkfTesCws5g" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" formula="t2woicz-30qSFYt6mQCHeA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="hi3ZGAeSYkS5lEQ-taNnSA" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="GUZN29fSE0ONZHD3X8VwiA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="a-DMsTrmPU6iK9VgyH5T6Q" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="IOkzA_UEJkS0HuM9fD-CCQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="ZX7rIz-YdUSij9F663oTzA" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="UMOREOeGmk-pmJcOEYoOdQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="lw4ZpZjftEKsk7d2b0adbw" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="0JEUwwJAikivj4Kq4o0gPw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="KNVMD2xTIEqo6txLQ3DKaw" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="lpIDqjD9gEWmtbKf3q84VA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="IemSqFSLJkqRWnQB-oZs2A" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="6__4dds080mhMGgrvZbAdg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="-_1Zl_OsI0OlPpM_6kMp-g" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="PrHeLjsYykSkmUtQHhmBOg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="5-zBnZnMKkOy-TP3GsWWEg" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="rabwZORJhEaP_fHrkA4XIg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="DTOvQPwKIUmlvlTEL_zhMA" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="EwkWYsgR6E6_8KFR1rpMFQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="PbO96m5mqUCKDvOO7Rrjqg" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="jAdw3FplFEOtMuaa3nWXqQ" dim="Dimensionless" quantityType="0" />
-                        <Container id="BkigLfGvSkiooZ67DLK2NQ" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Plasma" />
-                            <Tag value="ColonAscendens" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="4tcaVeE6z0-gLzCetwyAhQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="owgI66XQcE2ClB4BHV50ew" dim="Volume" quantityType="0" />
-                            <Parameter id="UPOfoo-wFUWkh8rmk5C-kw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="rbp4e7PXpUyuD1ZtA8Ocxw" dim="Volume" quantityType="0" />
-                            <MoleculeAmount id="6ewOCi0jbU6RbncNeaX1hw" name="Drug" icon="Drug" persistable="0" isFixedValue="0" formula="pxJZ_2M4QkynE-j8cmkdww" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="WQubxFWFrUiI06HYvE8cjQ" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Parameter id="Fn4Vk2ZlvkaOJZOuWTzrWA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="Ay4OY7Z0BESxtFLw9wadyw" dim="Dimensionless" quantityType="0" />
-                                <Observer id="SEvJPOELZU6bhCpemuk2cg" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Drug, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                            <MoleculeAmount id="Mjt1rZ1Jbk2V9fOzFWYlbw" name="Cyp" icon="Enzyme" persistable="0" isFixedValue="0" formula="wb5yCXJZxUeVY_7iSBmoSg" dim="Amount" quantityType="Enzyme" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="DR5R5wnNAkmk6mYVvO7Kwg" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" formula="4-dD-foisUSTHpicZSgT4g" dim="Dimensionless" quantityType="0" />
-                                <Parameter id="4nf7jUj3ykOxDgVcP5LtDw" name="Relative expression out." description="Relative Expression that will be used in the simulation" persistable="0" isFixedValue="0" formula="GtBZCb_uvUKgURPKDkyZKA" dim="Fraction" quantityType="0" />
-                                <Parameter id="aDyEmNWbaEi_tTFzp853Uw" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" persistable="0" isFixedValue="0" formula="Qv2OyMi-nU-kPqJ48WVuVw" dim="Fraction" quantityType="0" />
-                                <Parameter id="Shdo2J6r4kWMaCpQYqCuFg" name="Relative expression" description="Relative expression" persistable="0" isFixedValue="0" formula="iUzjEbj_NkSh4u8TNBhFgQ" dim="Fraction" quantityType="0" />
-                                <Parameter id="UWOEAGGERkWrUh9y63e5BQ" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Observer id="8lzRzXnr0UikJe6Whld4eg" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Enzyme, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                            <MoleculeAmount id="4zj5XUXzZ0usal8gw5QZAw" name="Drug-Cyp Metabolite" persistable="0" isFixedValue="0" formula="-CeVUaSLZkS8KPzMa6jZPg" dim="Amount" quantityType="Metabolite" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="fhfZfhCDUECrpAFBruRubA" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Observer id="PoswPvR-S0a8-gjPWltFZg" name="Fraction of dose" description="Metabolized fraction of administered dose" persistable="1" isFixedValue="0" formula="aUoTQ3n3a0OShljd8bUj3w" dim="Fraction" quantityType="Metabolite, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                            <Reaction id="Mzo8aviUUU-Q6Ih8qI2LEQ" name="Cyp-ME" icon="Metabolism" mode="Logical" containerType="Other" dimension="Dimensionless" formula="NrKgrsKmwkiGET1q7OIPYg">
-                              <Educts>
-                                <ReactionPartner stoichiometricCoefficient="1" partner="6ewOCi0jbU6RbncNeaX1hw" />
-                              </Educts>
-                              <Products>
-                                <ReactionPartner stoichiometricCoefficient="1" partner="4zj5XUXzZ0usal8gw5QZAw" />
-                              </Products>
-                              <ModifierNames>
-                                <ModifierNamesChild>Cyp</ModifierNamesChild>
-                              </ModifierNames>
-                            </Reaction>
-                          </Children>
-                        </Container>
-                        <Container id="aBWYhB1S5EmhC-3vnT5kZg" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="BloodCells" />
-                            <Tag value="ColonAscendens" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="QkxCZuo9FkGPsdwTBwqQ2w" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="owgI66XQcE2ClB4BHV50ew" dim="Volume" quantityType="0" />
-                            <Parameter id="VRbyr_kluUupVybNu6Ia-g" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="tFZiRJ-Sv0qf0gsV7ycmYw" dim="Volume" quantityType="0" />
-                            <MoleculeAmount id="2LtEnxRQ-E68v82BoICp1A" name="Drug" icon="Drug" persistable="0" isFixedValue="0" formula="mMMXxmaem02edJc3Ecpf-w" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="EdBriwoFUk6v9knFw3gnNQ" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Parameter id="c0E2b6qrXUys0o9oKCfoNA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="d4DvFdUock-rno4L-keoeg" dim="Dimensionless" quantityType="0" />
-                                <Observer id="ZXgx4ONDJkSYd0AJqsRodA" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Drug, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                            <MoleculeAmount id="ePNoiz-Hr0evqHXkRdrqCA" name="Cyp" icon="Enzyme" persistable="0" isFixedValue="0" formula="wb5yCXJZxUeVY_7iSBmoSg" dim="Amount" quantityType="Enzyme" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="OwGzM0HIS06mY_X_TX9rtQ" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" formula="hDWgmMNEo0KRlt21rr1mrw" dim="Dimensionless" quantityType="0" />
-                                <Parameter id="YxDh9Qu7T0qEYUmhT5gqfw" name="Relative expression out." description="Relative Expression that will be used in the simulation" persistable="0" isFixedValue="0" formula="GtBZCb_uvUKgURPKDkyZKA" dim="Fraction" quantityType="0" />
-                                <Parameter id="a-ED-hJEh0qteSAo1GCuOg" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" persistable="0" isFixedValue="0" formula="FTxLv_b4CkKigLwWdcA4xg" dim="Fraction" quantityType="0" />
-                                <Parameter id="JJDnF5vBpUCQBzaKdEEEJw" name="Relative expression" description="Relative expression" persistable="0" isFixedValue="0" formula="_J3C13ewoUatoCS2w-zxeg" dim="Fraction" quantityType="0" />
-                                <Parameter id="7ovBD5qhEkyxcmUYMBOmkQ" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Observer id="GeN9zaEX50a13qoqIQ1dXg" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Enzyme, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                            <MoleculeAmount id="ecs42sApSEKCW5nShNa-DQ" name="Drug-Cyp Metabolite" persistable="0" isFixedValue="0" formula="yjPJ3V80sU2BHg8iNxpQUg" dim="Amount" quantityType="Metabolite" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="5iNLfzE6n0iQZBZqGe7mOw" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Observer id="BZcSI2i-8EusY7K4-6Y1Ng" name="Fraction of dose" description="Metabolized fraction of administered dose" persistable="1" isFixedValue="0" formula="aUoTQ3n3a0OShljd8bUj3w" dim="Fraction" quantityType="Metabolite, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                            <Reaction id="oIVZ4OXwQUmejc1Rzl3B9A" name="Cyp-ME" icon="Metabolism" mode="Logical" containerType="Other" dimension="Dimensionless" formula="NrKgrsKmwkiGET1q7OIPYg">
-                              <Educts>
-                                <ReactionPartner stoichiometricCoefficient="1" partner="2LtEnxRQ-E68v82BoICp1A" />
-                              </Educts>
-                              <Products>
-                                <ReactionPartner stoichiometricCoefficient="1" partner="ecs42sApSEKCW5nShNa-DQ" />
-                              </Products>
-                              <ModifierNames>
-                                <ModifierNamesChild>Cyp</ModifierNamesChild>
-                              </ModifierNames>
-                            </Reaction>
-                          </Children>
-                        </Container>
-                        <Container id="3wSRCym4P0qw0qkBrNzwjA" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Interstitial" />
-                            <Tag value="ColonAscendens" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="0SzFs40jmkaMJMhevqti2w" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="owgI66XQcE2ClB4BHV50ew" dim="Volume" quantityType="0" />
-                            <Parameter id="_JAp5-9tY0CX3VU7tRdDzw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="4VSppd3W3E6-12kllCJ0Mg" dim="Volume" quantityType="0" />
-                            <Parameter id="cZ9R29SonUKUBHuSK_9-oQ" name="pH" description="pH" persistable="0" isFixedValue="0" formula="tKjHIxsi60KoHEPhXQBZrw" dim="Dimensionless" quantityType="0" />
-                            <MoleculeAmount id="G2LxNyTHWEOKC4Gnxt18xA" name="Drug" icon="Drug" persistable="0" isFixedValue="0" formula="UJB9qXkj3k66MSxcfdL5Sw" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="UQxfX95EUUuFZEzLB1BFOg" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Parameter id="CbyXFd5HgEiSmAZcpgFBlA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="qwy0fYCjtEC8iCkBeWBTaQ" dim="Dimensionless" quantityType="0" />
-                                <Observer id="aNALgl2T9E-3PjLIgUD7LQ" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Drug, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                          </Children>
-                        </Container>
-                        <Container id="iBBpeGvAM0mWO2YbgWcZFw" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Intracellular" />
-                            <Tag value="ColonAscendens" />
-                            <Tag value="IntestinalSecretionSource" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="X2OWrrIP80eq-KXlRIrYYA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="M9arQg_qfEGMA7JdlSXkFA" dim="Volume" quantityType="0" />
-                            <Parameter id="GsPgI8PG3UWP1Rp93vb8Rw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="3l84whkuX0S7xUUHglUQpg" dim="Volume" quantityType="0" />
-                            <Parameter id="4Ey_Bi2_l0WuCkHWakCgZA" name="pH" description="pH" persistable="0" isFixedValue="0" formula="dfVKC0riqkKscT7xUkQULg" dim="Dimensionless" quantityType="0" />
-                            <MoleculeAmount id="xnxvY69E7EKFACGGZTKgzg" name="Drug" icon="Drug" persistable="0" isFixedValue="0" formula="DcBnrPZap02oTnpvQX5jOg" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="99msFpd820yvDLeJ11UGRg" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Parameter id="2g-oJZXo_UeBnFzpj1axmg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="IOON1koFN0SQjOmxIelcRg" dim="Dimensionless" quantityType="0" />
-                                <Observer id="NeMAmRjcGkanUDCXHL7e_Q" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Drug, Observer" />
-                              </Children>
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-                            <MoleculeAmount id="uPHcmiyz8U-QdkzzWCIlgg" name="Cyp" icon="Enzyme" persistable="0" isFixedValue="0" formula="wb5yCXJZxUeVY_7iSBmoSg" dim="Amount" quantityType="Enzyme" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="FRr82amHi06v0BvDspPSZg" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" formula="TyrNVUlv4kyYVdaKmHHD6g" dim="Dimensionless" quantityType="0" />
-                                <Parameter id="n9nnob2bz0OhzVkbsPOrIg" name="Relative expression out." description="Relative Expression that will be used in the simulation" persistable="0" isFixedValue="0" formula="GtBZCb_uvUKgURPKDkyZKA" dim="Fraction" quantityType="0" />
-                                <Parameter id="ee7G52q_gU2ZCQT6J6z5Ug" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" persistable="0" isFixedValue="0" formula="gL1HENXkkUe_AoDHxBr3OQ" dim="Fraction" quantityType="0" />
-                                <Parameter id="XtfN8OyEe0CNHUAg0-8vKw" name="Relative expression" description="Relative expression" persistable="0" isFixedValue="0" formula="TPQA8chaREajaxc__NgeXQ" dim="Fraction" quantityType="0" />
-                                <Parameter id="v86l-Uyqsk2nzq4dxlLAJQ" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
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-                              </Children>
-                            </MoleculeAmount>
-                            <MoleculeAmount id="s6soDMX_pEqE4xVhJaxkFw" name="Drug-Cyp Metabolite" persistable="0" isFixedValue="0" formula="rwS3_or9t0OkJhkDf-EsHQ" dim="Amount" quantityType="Metabolite" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="0zHsIkToA0iilWIOQ3_V4Q" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Observer id="p5qFmtYqWUmaDiH7ZRsnYw" name="Fraction of dose" description="Metabolized fraction of administered dose" persistable="1" isFixedValue="0" formula="aUoTQ3n3a0OShljd8bUj3w" dim="Fraction" quantityType="Metabolite, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                            <Reaction id="eeqWqB2yd0yJAFNyLn2blg" name="Cyp-ME" icon="Metabolism" mode="Logical" containerType="Other" dimension="Dimensionless" formula="NrKgrsKmwkiGET1q7OIPYg">
-                              <Educts>
-                                <ReactionPartner stoichiometricCoefficient="1" partner="xnxvY69E7EKFACGGZTKgzg" />
-                              </Educts>
-                              <Products>
-                                <ReactionPartner stoichiometricCoefficient="1" partner="s6soDMX_pEqE4xVhJaxkFw" />
-                              </Products>
-                              <ModifierNames>
-                                <ModifierNamesChild>Cyp</ModifierNamesChild>
-                              </ModifierNames>
-                            </Reaction>
-                          </Children>
-                        </Container>
-                      </Children>
-                    </Container>
-                    <Container id="YyD7BPDnXk2xDfSsgMGeGg" name="ColonTransversum" description="Colon Transversum" icon="ColonTransversum" mode="Logical" containerType="Compartment">
-                      <Tags>
-                        <Tag value="ColonTransversum" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="RICq7v-mpkWSwpoVzZqysQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="-gTq6hcOAkux2quE5KvEjw" dim="Volume" quantityType="0" />
-                        <Parameter id="WkAtxVpYdkCKwNn-8r8X6Q" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" formula="hB48fjDKB0aPhnPyDobY9g" dim="Flow (volume)" quantityType="0" />
-                        <Parameter id="fqoUN9PCpE6S-h4QRdJrvQ" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" formula="1iYOz2N_e0yQUVEj0em25g" dim="Volume" quantityType="0" />
-                        <Parameter id="_Ycs1XtBZkChcULDWoFjIg" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" formula="6e9LHlTFJkG-PMFyieazhw" dim="Flow (volume)" quantityType="0" />
-                        <Parameter id="YrMy2EdaT0aA7KD1pLD_wQ" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" formula="PSbm5ReMbUKRj9xRJC3ccA" dim="Flow (volume)" quantityType="0" />
-                        <Parameter id="mYgOv7UxI0-XwX5byYS4oQ" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" formula="FbGzbaLst0K5o2gc_gSjaQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="eAsiHfGotk--2CQByAehtQ" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" formula="6ImDLxwAtEaXB1LHDgkbag" dim="Density" quantityType="0" />
-                        <Parameter id="IjBCKvxnZUyOaTGHl880aQ" name="Fraction of regional blood flow rate" description="Regional blood flow fraction supplying the mucosal tissue of the segment" persistable="0" isFixedValue="0" formula="4ylUAu7EkkKO4wGEovi0Ig" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="qBZXl2RDSkiEnxlejigyUg" name="Fraction mucosa" description="Mucosal fraction of regional intestinal tissue mass" persistable="0" isFixedValue="0" formula="0bq-8NKFG0u62Tvo6Mt0nQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="cA-s6PHEtE65192YTO4YKg" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" formula="oKpzAK0Ar0ulGTTfo2cqFA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="SQmTvJ394kaat4PDGX76gw" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" formula="n-wy1Lhia0-PIowws3TdsQ" dim="Nanolength" quantityType="0" />
-                        <Parameter id="fEKsbH-Y6k20F3fxo57h6g" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" formula="XQUMu95dwEeXwOsWb1wiYQ" dim="HydraulicConductivity" quantityType="0" />
-                        <Parameter id="ObL1n3bRpUe4yjd6M9m5hw" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" formula="v1G2YQIEW0uC79ULH_ofyg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="npUaFPtR20aMzVreWoXhdA" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" formula="aNr55wwFb0uzqZRmhn723Q" dim="Nanolength" quantityType="0" />
-                        <Parameter id="qUGo3Ng8tUanliynBUozkw" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="BInyXuWy20yV1orwwDzAQw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="nRuuVkjeok6-xYQFH2xl7Q" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="q0PM4R17QUOxyNdpagPwjw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="8S5_5way5Ei9zECvyxrp9g" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" formula="0RMc47s69kCsCgNELCKHsQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="GiEBVYkKZEilXDQHZd46cw" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="RMhneWN8MEWFv2bRqllrDA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="5GoekJLkT0-dp1uiTX9WjA" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="rIxuDs32uUeW-544_9zNjg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="3fR7SqHVFUWCGdj1ML1QKg" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="28dJ6QPp-E-C6ts7Mnqcyg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="vnUASec3V06hRidIPkB2GQ" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="MSlCEALINU6lJIZjRTYsoA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="RcKapsUXpEGCCiYfrvcE2A" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="ehwetU2tqUyNBW51JeJ9qg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="hZVb-Qfv2kmRkBqek2cXPg" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="zI6koFkHVkaMyBNnIFHY8Q" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="wv2Wggm7zUCpbBFMLuDs0Q" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="LXaO5_d3okWFJoIpjZebzg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="_uhxf4lGl0C6Ngfw6DC8wA" name="Microsomal protein mass/g tissue" description="Microsomal protein content per gram tissue" persistable="0" isFixedValue="0" formula="v79yDEEkREeM6Dl3opvvHA" dim="MassProteinPerTissue" quantityType="0" />
-                        <Parameter id="sXPJZwF3SEKldNjUJnCv6Q" name="Protein mass/g tissue" description="Total protein content per gram tissue" persistable="0" isFixedValue="0" formula="vGxv9-j_jEa-wjjmTdrG_Q" dim="MassProteinPerTissue" quantityType="0" />
-                        <Parameter id="anusNzAnZUKF3FvFDG85HA" name="Number of cells/g tissue" description="Number of cells per gram tissue" persistable="0" isFixedValue="0" formula="ltWC_g3zZU-b1mpHG0laoQ" dim="CellQuantityPerTissue" quantityType="0" />
-                        <Parameter id="ZjH1KBeW0UiQeTt4SsoKVA" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" formula="UKnvb67V80yn3stA__IKtw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="-T3PIh6TzEecTQoHxYvJSA" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="eyBw5UIpPEqqEpNvBMmdQA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="3F_CExhq3kKdhZ1qiv7pyg" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="22UTK4NRkkm-0CGbp58gyA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="dLUTkTZy5ECZhTum3MZIog" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="2XnyrOfjl0--5uhmX6w5eA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="ZKhNRke5qECKWbYaWfuKVg" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="fSVwsHIX40m3kRHEai75eA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="EnXyWxmpj02bLeqyI7qcUw" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="Q7Tz5-gF3kyHBUmAM8BlTw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="5YBM6tKQYkyve1UllL_NEw" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="7T-CW0zShU6PQtz0vuI0MA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="zUea664Ow0WU0qf_XIBf5Q" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="3P1o1_8dDkGQcbOsuyUEaw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="qG2MBu6zok2BQZVGzmtjQw" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="IFBTJnhWvkiff6IbDIOp-w" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="HeKyYReSX0yk1W2I3ayVVA" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="shj8Teh3mEOu8nUZwAPAsg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="joq2VqX6JU259FddZTyBuA" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="8h87bxvEUkeHiObpTMMSXg" dim="Dimensionless" quantityType="0" />
-                        <Container id="j1XM0vRHAEaTiu2blg0NgQ" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Plasma" />
-                            <Tag value="ColonTransversum" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="5SAGsZnVh0GgET9SbjjK1w" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="owgI66XQcE2ClB4BHV50ew" dim="Volume" quantityType="0" />
-                            <Parameter id="ssJHSfB6cEG5JUk6-3u6HQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="rbp4e7PXpUyuD1ZtA8Ocxw" dim="Volume" quantityType="0" />
-                            <MoleculeAmount id="SLgG3jH9c0WpTyMIPQBI2g" name="Drug" icon="Drug" persistable="0" isFixedValue="0" formula="nCPpNoMw7kmCMidVByBOJA" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="zLG3btaGR0aeV6sl7mJHCg" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Parameter id="frxtpk30eE-8aYrI-xOf2g" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="PpV8gj2qREuXTScbUtL5VA" dim="Dimensionless" quantityType="0" />
-                                <Observer id="GmLQOB_WWEK-Fb9Y0u_5ZA" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Drug, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                            <MoleculeAmount id="EcjKsam0qkmIliXzVU1Tlg" name="Cyp" icon="Enzyme" persistable="0" isFixedValue="0" formula="wb5yCXJZxUeVY_7iSBmoSg" dim="Amount" quantityType="Enzyme" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="pAy-BvgGYEa3IDP7mK8oyw" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" formula="bK-PHHbMJkmjspN7t5hP_w" dim="Dimensionless" quantityType="0" />
-                                <Parameter id="xZU-B3-bAkuT8t-GW4WApA" name="Relative expression out." description="Relative Expression that will be used in the simulation" persistable="0" isFixedValue="0" formula="GtBZCb_uvUKgURPKDkyZKA" dim="Fraction" quantityType="0" />
-                                <Parameter id="xZHlAl7DDEWeSTETtZ8V1A" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" persistable="0" isFixedValue="0" formula="Qv2OyMi-nU-kPqJ48WVuVw" dim="Fraction" quantityType="0" />
-                                <Parameter id="1tJtUg7wzkGZYAp9N841ZQ" name="Relative expression" description="Relative expression" persistable="0" isFixedValue="0" formula="iUzjEbj_NkSh4u8TNBhFgQ" dim="Fraction" quantityType="0" />
-                                <Parameter id="tnIIMSKstEyMqSJbDIB2Ew" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Observer id="4xK9lKZfnE6NUPCBekZ5tw" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Enzyme, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                            <MoleculeAmount id="RHFra5suDUq5OQ5gww6r4g" name="Drug-Cyp Metabolite" persistable="0" isFixedValue="0" formula="ARy6B-Jp3UWd0_gh8xiI5A" dim="Amount" quantityType="Metabolite" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="6a40oF8vOUu1aHzmlkypOg" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Observer id="8vmwfbFbkU6YGXhX2w2F7w" name="Fraction of dose" description="Metabolized fraction of administered dose" persistable="1" isFixedValue="0" formula="aUoTQ3n3a0OShljd8bUj3w" dim="Fraction" quantityType="Metabolite, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                            <Reaction id="YrRRQJYupUiDqkR8-VEFhA" name="Cyp-ME" icon="Metabolism" mode="Logical" containerType="Other" dimension="Dimensionless" formula="NrKgrsKmwkiGET1q7OIPYg">
-                              <Educts>
-                                <ReactionPartner stoichiometricCoefficient="1" partner="SLgG3jH9c0WpTyMIPQBI2g" />
-                              </Educts>
-                              <Products>
-                                <ReactionPartner stoichiometricCoefficient="1" partner="RHFra5suDUq5OQ5gww6r4g" />
-                              </Products>
-                              <ModifierNames>
-                                <ModifierNamesChild>Cyp</ModifierNamesChild>
-                              </ModifierNames>
-                            </Reaction>
-                          </Children>
-                        </Container>
-                        <Container id="4h08SDSRP0uZygWcIRA7mg" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="BloodCells" />
-                            <Tag value="ColonTransversum" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="9meIHZE6o0arZdunn4K5Zg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="owgI66XQcE2ClB4BHV50ew" dim="Volume" quantityType="0" />
-                            <Parameter id="HynYl9rwZkyACVZTbWQhgw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="tFZiRJ-Sv0qf0gsV7ycmYw" dim="Volume" quantityType="0" />
-                            <MoleculeAmount id="DQ3BvfhWu0maydUENsDylg" name="Drug" icon="Drug" persistable="0" isFixedValue="0" formula="RDaS6FeL80e2TYY5t25-uA" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="5SW57yysCEO43ASol8_5hg" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Parameter id="KseWCa-aSE2SfDhoiRKJow" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="6yMvSY-49EuqjEQjH_jUVQ" dim="Dimensionless" quantityType="0" />
-                                <Observer id="t_5RwHzaHEKvRHBfFj41Hg" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Drug, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                            <MoleculeAmount id="KlicWXgMkUOUP5w8XvXzyQ" name="Cyp" icon="Enzyme" persistable="0" isFixedValue="0" formula="wb5yCXJZxUeVY_7iSBmoSg" dim="Amount" quantityType="Enzyme" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="3So7o_0W-0aJ-2UHpTnLpA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" formula="vziHJgB0dUCrYGeWKufvxw" dim="Dimensionless" quantityType="0" />
-                                <Parameter id="zPKfS5zpA0yuEMUIeVVTdQ" name="Relative expression out." description="Relative Expression that will be used in the simulation" persistable="0" isFixedValue="0" formula="GtBZCb_uvUKgURPKDkyZKA" dim="Fraction" quantityType="0" />
-                                <Parameter id="QnT_Knhn4EesPizAqIp-fA" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" persistable="0" isFixedValue="0" formula="FTxLv_b4CkKigLwWdcA4xg" dim="Fraction" quantityType="0" />
-                                <Parameter id="Ange-Dxe8EKG81ysNI_CoQ" name="Relative expression" description="Relative expression" persistable="0" isFixedValue="0" formula="_J3C13ewoUatoCS2w-zxeg" dim="Fraction" quantityType="0" />
-                                <Parameter id="jaD1jKDFKkGLJ6gNhY-SmQ" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Observer id="VdOxeua-wESlfWEHyCTK1Q" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Enzyme, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                            <MoleculeAmount id="VHZev4kWmE6NftAPDnSf1A" name="Drug-Cyp Metabolite" persistable="0" isFixedValue="0" formula="hzqN_UrAIE2fMB31z5UMkQ" dim="Amount" quantityType="Metabolite" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="lbdRi-f6WkOrlaFgbMozsQ" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Observer id="4XFDcAGRykORg6_RpzdJrg" name="Fraction of dose" description="Metabolized fraction of administered dose" persistable="1" isFixedValue="0" formula="aUoTQ3n3a0OShljd8bUj3w" dim="Fraction" quantityType="Metabolite, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                            <Reaction id="s0aXZ05bkUSpYFgc1lat6A" name="Cyp-ME" icon="Metabolism" mode="Logical" containerType="Other" dimension="Dimensionless" formula="NrKgrsKmwkiGET1q7OIPYg">
-                              <Educts>
-                                <ReactionPartner stoichiometricCoefficient="1" partner="DQ3BvfhWu0maydUENsDylg" />
-                              </Educts>
-                              <Products>
-                                <ReactionPartner stoichiometricCoefficient="1" partner="VHZev4kWmE6NftAPDnSf1A" />
-                              </Products>
-                              <ModifierNames>
-                                <ModifierNamesChild>Cyp</ModifierNamesChild>
-                              </ModifierNames>
-                            </Reaction>
-                          </Children>
-                        </Container>
-                        <Container id="jMOo8Y0r2kymd4Qciv0Vvw" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Interstitial" />
-                            <Tag value="ColonTransversum" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="70AhxoN0GkeEvRxNAcn-dA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="owgI66XQcE2ClB4BHV50ew" dim="Volume" quantityType="0" />
-                            <Parameter id="niiSZkLcYECsdVBYo55lxg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="4VSppd3W3E6-12kllCJ0Mg" dim="Volume" quantityType="0" />
-                            <Parameter id="OLSS2RLd40u5dHESVkW6Rw" name="pH" description="pH" persistable="0" isFixedValue="0" formula="tKjHIxsi60KoHEPhXQBZrw" dim="Dimensionless" quantityType="0" />
-                            <MoleculeAmount id="aiygZmKWoEGjGHg91OrE-A" name="Drug" icon="Drug" persistable="0" isFixedValue="0" formula="pwkAa934vky0KC1VOA92OA" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="cYmwV9VS4ky6XH9WO0BpHw" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Parameter id="xAqTC7mbp0SUeLIcX2YK1A" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="PxpMBebPNEaCbVc9Sre2iA" dim="Dimensionless" quantityType="0" />
-                                <Observer id="4o0s_Sty1EWI2plK8NPj_Q" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Drug, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                          </Children>
-                        </Container>
-                        <Container id="ajdb6xz_Z0eFXoBiRThZCA" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Intracellular" />
-                            <Tag value="ColonTransversum" />
-                            <Tag value="IntestinalSecretionSource" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="Xzn-00AlQkqEugazwt8tcw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="M9arQg_qfEGMA7JdlSXkFA" dim="Volume" quantityType="0" />
-                            <Parameter id="vBspy6PewkiSpZ5LargWWw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="3l84whkuX0S7xUUHglUQpg" dim="Volume" quantityType="0" />
-                            <Parameter id="38_h0vxm0EGMlzHbm0m0Xg" name="pH" description="pH" persistable="0" isFixedValue="0" formula="tDkR-ZvLlUqW2gholszPng" dim="Dimensionless" quantityType="0" />
-                            <MoleculeAmount id="V5etuBdFRkuq-Q1hP1f8zg" name="Drug" icon="Drug" persistable="0" isFixedValue="0" formula="IUuBUkgAQE-IjFePNGEwbw" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="Sgp_7hrHo0OMbRsLV17H9g" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Parameter id="BfdbDEuveEGeXbPWF6yOfw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="cNtAIWSyakWAE1FUE8aW3w" dim="Dimensionless" quantityType="0" />
-                                <Observer id="idZNIdHRIUOLk3z2zlyFPw" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Drug, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                            <MoleculeAmount id="b4K0ESk6Q0GU7hYAM3x_MQ" name="Cyp" icon="Enzyme" persistable="0" isFixedValue="0" formula="wb5yCXJZxUeVY_7iSBmoSg" dim="Amount" quantityType="Enzyme" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="-OZqDQltzkiHf3obQfzAeA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" formula="NUmE6c0G5ki2TzNOEJwWiA" dim="Dimensionless" quantityType="0" />
-                                <Parameter id="yXFwF0I3oEWLt8aXwb8q4Q" name="Relative expression out." description="Relative Expression that will be used in the simulation" persistable="0" isFixedValue="0" formula="GtBZCb_uvUKgURPKDkyZKA" dim="Fraction" quantityType="0" />
-                                <Parameter id="Q9nrp1lFSEy0YmwaVzz7hQ" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" persistable="0" isFixedValue="0" formula="mg21Y7DmvEKbvrvByszlUw" dim="Fraction" quantityType="0" />
-                                <Parameter id="8OlIP2n4wUCyclPqmBLC7A" name="Relative expression" description="Relative expression" persistable="0" isFixedValue="0" formula="3WeR0NjeMEOnVruAhntDHQ" dim="Fraction" quantityType="0" />
-                                <Parameter id="dZJl0Z9QVE-w6-y6PGhyKQ" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Observer id="8XoU37LQ902kePB7lkAPPQ" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Enzyme, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                            <MoleculeAmount id="Pg_uFM2SSEay1OLOTtXoMw" name="Drug-Cyp Metabolite" persistable="0" isFixedValue="0" formula="NA_CnClALkizORpORrFMAA" dim="Amount" quantityType="Metabolite" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="sPa-4yV5ME6U-D85p9Y8sA" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Observer id="EqMCOoeuFkS2QP96kVrHhg" name="Fraction of dose" description="Metabolized fraction of administered dose" persistable="1" isFixedValue="0" formula="aUoTQ3n3a0OShljd8bUj3w" dim="Fraction" quantityType="Metabolite, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                            <Reaction id="Cb4756mWZUqjAcShVIl5gA" name="Cyp-ME" icon="Metabolism" mode="Logical" containerType="Other" dimension="Dimensionless" formula="NrKgrsKmwkiGET1q7OIPYg">
-                              <Educts>
-                                <ReactionPartner stoichiometricCoefficient="1" partner="V5etuBdFRkuq-Q1hP1f8zg" />
-                              </Educts>
-                              <Products>
-                                <ReactionPartner stoichiometricCoefficient="1" partner="Pg_uFM2SSEay1OLOTtXoMw" />
-                              </Products>
-                              <ModifierNames>
-                                <ModifierNamesChild>Cyp</ModifierNamesChild>
-                              </ModifierNames>
-                            </Reaction>
-                          </Children>
-                        </Container>
-                      </Children>
-                    </Container>
-                    <Container id="JxvxeKeSH0iUDEf5lN8gDg" name="ColonDescendens" description="Colon Descendens / Distal Colon 1" icon="ColonDescendens" mode="Logical" containerType="Compartment">
-                      <Tags>
-                        <Tag value="ColonDescendens" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="XSyP8pm02UWIPrgslJdWaQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="gGNJJ7MplkeIYb00Xz2fcg" dim="Volume" quantityType="0" />
-                        <Parameter id="g-Mcj0eyS06vvmilZf-MVA" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" formula="kKYlk3gnT06CVNcj5eIWPA" dim="Volume" quantityType="0" />
-                        <Parameter id="PHDzwT1WTUijpT2r3gThQg" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" formula="hB48fjDKB0aPhnPyDobY9g" dim="Flow (volume)" quantityType="0" />
-                        <Parameter id="wkNJasDDPU2eFKkJXhSz_Q" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" formula="6e9LHlTFJkG-PMFyieazhw" dim="Flow (volume)" quantityType="0" />
-                        <Parameter id="GKuFn8Fk9EKTM6h7gx05Iw" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" formula="PSbm5ReMbUKRj9xRJC3ccA" dim="Flow (volume)" quantityType="0" />
-                        <Parameter id="hGtrOhRQ2kStzkwo6FAprw" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" formula="FbGzbaLst0K5o2gc_gSjaQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="m0tddmyXsEaC7pzKvz4-RQ" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" formula="JX_Qh6gpokemMfPOXMh0Sg" dim="Density" quantityType="0" />
-                        <Parameter id="PpiiQoEmM0S5uh17lJu2_A" name="Fraction of regional blood flow rate" description="Regional blood flow fraction supplying the mucosal tissue of the segment" persistable="0" isFixedValue="0" formula="fSbVIZnceUuqYRq5iyH7nQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="11SMxB7s70KDWt7PRmA1Wg" name="Fraction mucosa" description="Mucosal fraction of regional intestinal tissue mass" persistable="0" isFixedValue="0" formula="0biMRPud0k-EMojd99Oq_g" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="MJBzNL_alUyy6RSBvZopjQ" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" formula="7oL0wmRUTUeomoYVOwVX2w" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="mDxKOQWXv06nlG6BeaCefA" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" formula="yeY3BZVdeUu7zeLKMP7d0w" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="BfpGFow15kWtY3hyqCnYyQ" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" formula="xnJsZBI0FUanzn9zDN5rEQ" dim="Nanolength" quantityType="0" />
-                        <Parameter id="5oD16NC8HkKmCIdhlBq33w" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" formula="7PqmjM0jgUyJnSXRZVvRug" dim="Nanolength" quantityType="0" />
-                        <Parameter id="kDdD5o3jqUK_6rWuSAbtiQ" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" formula="TcfxvSTqqkuAJYi4Eb_AUA" dim="HydraulicConductivity" quantityType="0" />
-                        <Parameter id="rOcD3PabGkiNnwhMu47Zyg" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="hCnHb3dvuUCdzc7ayis_Yw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="ZfYILxwCBke5WrgjdNhNxw" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="RdKwfFTfVUCnhOLP2rMvAQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="_TVsVb-OUEGtzT3lzBoPiQ" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" formula="YwlUQTzmDESincvsjBlHmQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="-SBFkJIMqUCNm0lApbm81A" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="anYfha8u0E6OkOLZTcYiBw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="wlCDwDCpe0iuirmr91VgSA" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="5yZlkmepM0CSwr7BFayykA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="3sPbp7uYOE6Udv5YzHCVlw" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="l6vFJ-3fV0q-rbzqR4crtw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="pjl7gk0RV0OLBBQ1QFKGuA" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="FkZ9wHhFPUiBx-JgKhNscA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="tZYb-UpuKkCtQecGbo9RqA" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="g4tFy3SxiUOfwRASps6ZFQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="2tKnSNC-M0GZq9a9z-ZwJg" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="AA0KbgzUp0SPNwqI9zpUvg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="WRtcrdJ7r06aslM_mFYoGw" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="qOqKqp39lUam7RUj5cGgOw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="v0wnFW71dEukO267817CWQ" name="Protein mass/g tissue" description="Total protein content per gram tissue" persistable="0" isFixedValue="0" formula="1OiL70EB8kOsEqUSj3U4zA" dim="MassProteinPerTissue" quantityType="0" />
-                        <Parameter id="H_b05iWwe0OsiDxuETdi6g" name="Number of cells/g tissue" description="Number of cells per gram tissue" persistable="0" isFixedValue="0" formula="0LzTIjjbUE66gs45tZMMtg" dim="CellQuantityPerTissue" quantityType="0" />
-                        <Parameter id="fheI9vPEiE2F9y78aQWqbA" name="Microsomal protein mass/g tissue" description="Microsomal protein content per gram tissue" persistable="0" isFixedValue="0" formula="YPLX0KK2N0ejVJByicGVdw" dim="MassProteinPerTissue" quantityType="0" />
-                        <Parameter id="bUpgsUukHEG7jAENvuS0Zg" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" formula="SZWkGI2UkU652qwooo0eig" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="XFtDSSewqkaemmiDQHlZ_w" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="XmH8ekfOP0WTIpKn1fkyyQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="nvM3ArX5CUCxAD4KpVQE-g" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="STJekZ9EPUW9RUh78tzeeQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="Rx7UwnGgVEi2nRTuGKWnmg" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="irPpb3kGfUynZ-hf7HnNcw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="kR1sI1xdMkawQOkrCq0Cfg" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="n-ZdudrBUk2rL_Bt4ObvYA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="yy82S48KKU2xGulki37a4g" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="1IOO0Xmp7Ui4odwZkJjCPQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="lxpWhDrFuk63crQPnk0iJg" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="wT9_b8x1Vk6or8f3M5y5tA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="Yol_1C8izkyhn1LAHW3dDg" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="ekpsS0AG2EuMwcGI6zvAVg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="QRwQZpe5uUy-wgQIaxIt2w" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="d9R929CPhEiSTruvhf9EVA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="ji5edS_Ef0COu9GrRv1ecA" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="SO6DK7lpT0mLeOezyUWlug" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="AN-tWXKBiEa15rJbPrRexg" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="I3SS2GQ4O0yi9Yg0v1V89A" dim="Dimensionless" quantityType="0" />
-                        <Container id="PJgrM6BcSUav3cqJRrmkNA" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Plasma" />
-                            <Tag value="ColonDescendens" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="HZN48QBeVk2vR9G92z-62g" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="owgI66XQcE2ClB4BHV50ew" dim="Volume" quantityType="0" />
-                            <Parameter id="1m4cGeFRU0yzvvf5RS6a-g" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="rbp4e7PXpUyuD1ZtA8Ocxw" dim="Volume" quantityType="0" />
-                            <MoleculeAmount id="W3SdEs2fVUKbnj5EqVBLXw" name="Drug" icon="Drug" persistable="0" isFixedValue="0" formula="pLpl5wwTHk28i44RR1Q7jQ" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="4xXvxiGCFEep_9CGllaifQ" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Parameter id="S5K7rLwznkidKB4LgFrdaA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="ST3rLcl1u0yFzC_Z_PHVYw" dim="Dimensionless" quantityType="0" />
-                                <Observer id="U1SaVVS8AkWfYOdxpbva_g" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Drug, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                            <MoleculeAmount id="J3qniGD7n0S0mp_49iozoQ" name="Cyp" icon="Enzyme" persistable="0" isFixedValue="0" formula="wb5yCXJZxUeVY_7iSBmoSg" dim="Amount" quantityType="Enzyme" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="FkPzF_Od1UytlxGRdGqdfA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" formula="r5PJrMhv50a10hU9PB2kGA" dim="Dimensionless" quantityType="0" />
-                                <Parameter id="yxD5yfgdeE621e-tL9M2Ig" name="Relative expression out." description="Relative Expression that will be used in the simulation" persistable="0" isFixedValue="0" formula="GtBZCb_uvUKgURPKDkyZKA" dim="Fraction" quantityType="0" />
-                                <Parameter id="lYR64CDMbkWpV49-jyVfhw" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" persistable="0" isFixedValue="0" formula="Qv2OyMi-nU-kPqJ48WVuVw" dim="Fraction" quantityType="0" />
-                                <Parameter id="qP3m_vqUA068kgU760HBlw" name="Relative expression" description="Relative expression" persistable="0" isFixedValue="0" formula="iUzjEbj_NkSh4u8TNBhFgQ" dim="Fraction" quantityType="0" />
-                                <Parameter id="rTXMWhME50CquD-PtT-EFg" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Observer id="q52kxs758kemJHUxW9SA_A" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Enzyme, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                            <MoleculeAmount id="1a4e6JDJX06RyleppklNWA" name="Drug-Cyp Metabolite" persistable="0" isFixedValue="0" formula="eSjXxv9KuUa9i7fueLzeTQ" dim="Amount" quantityType="Metabolite" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="iEAz6wY8lkSmQuw5Hc7ivw" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Observer id="m5b_KjhwTE-DZCbesOY_Mw" name="Fraction of dose" description="Metabolized fraction of administered dose" persistable="1" isFixedValue="0" formula="aUoTQ3n3a0OShljd8bUj3w" dim="Fraction" quantityType="Metabolite, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                            <Reaction id="oD4tIwrU_EKm3iHpOamzmQ" name="Cyp-ME" icon="Metabolism" mode="Logical" containerType="Other" dimension="Dimensionless" formula="NrKgrsKmwkiGET1q7OIPYg">
-                              <Educts>
-                                <ReactionPartner stoichiometricCoefficient="1" partner="W3SdEs2fVUKbnj5EqVBLXw" />
-                              </Educts>
-                              <Products>
-                                <ReactionPartner stoichiometricCoefficient="1" partner="1a4e6JDJX06RyleppklNWA" />
-                              </Products>
-                              <ModifierNames>
-                                <ModifierNamesChild>Cyp</ModifierNamesChild>
-                              </ModifierNames>
-                            </Reaction>
-                          </Children>
-                        </Container>
-                        <Container id="atTfkMp6oU6CKOflJP6z3w" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="BloodCells" />
-                            <Tag value="ColonDescendens" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="W0d6aWd5h0KEQGARXwUe2Q" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="owgI66XQcE2ClB4BHV50ew" dim="Volume" quantityType="0" />
-                            <Parameter id="90WIcgr1UUSzxLYCUTXyvw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="tFZiRJ-Sv0qf0gsV7ycmYw" dim="Volume" quantityType="0" />
-                            <MoleculeAmount id="1EnMTQCxHkmgkxQCMDxj7Q" name="Drug" icon="Drug" persistable="0" isFixedValue="0" formula="_kzfaOEj2Ei0HsZuXcVItA" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="glMZVkSndU2uP2hMN1vMiA" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Parameter id="oGjdKhmV20C6PEfSGfEhCg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="FbPuQ7GvD0inpfjj_Uw8ow" dim="Dimensionless" quantityType="0" />
-                                <Observer id="vpPgs4Ng4EK7SoWjAyJzvA" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Drug, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                            <MoleculeAmount id="5gCKFITErkiS0vmFN03Zog" name="Cyp" icon="Enzyme" persistable="0" isFixedValue="0" formula="wb5yCXJZxUeVY_7iSBmoSg" dim="Amount" quantityType="Enzyme" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="zyiwXh42AkuRQp6DYUAweQ" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" formula="bKWRYDyO-UeW5dVph5JvwA" dim="Dimensionless" quantityType="0" />
-                                <Parameter id="Sch_sTEEQUadKqXCeqzSLA" name="Relative expression out." description="Relative Expression that will be used in the simulation" persistable="0" isFixedValue="0" formula="GtBZCb_uvUKgURPKDkyZKA" dim="Fraction" quantityType="0" />
-                                <Parameter id="wMR-4dXpdkm91CLquD1fGA" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" persistable="0" isFixedValue="0" formula="FTxLv_b4CkKigLwWdcA4xg" dim="Fraction" quantityType="0" />
-                                <Parameter id="Iic1BxleskaguiCWlowxLw" name="Relative expression" description="Relative expression" persistable="0" isFixedValue="0" formula="_J3C13ewoUatoCS2w-zxeg" dim="Fraction" quantityType="0" />
-                                <Parameter id="fHwQoFC55kG-pTd3yy_xnQ" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Observer id="lOYBsgVNTkGlDG3t57Gm0g" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Enzyme, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                            <MoleculeAmount id="nR0eNM5wvUSyevBnZmbiyw" name="Drug-Cyp Metabolite" persistable="0" isFixedValue="0" formula="2nmGQ9kDfkqagdZJU29mjA" dim="Amount" quantityType="Metabolite" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="Ii1AyxeEpU2GGQZQnUni2w" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Observer id="TchookxPb0Gj9wjM79bYzw" name="Fraction of dose" description="Metabolized fraction of administered dose" persistable="1" isFixedValue="0" formula="aUoTQ3n3a0OShljd8bUj3w" dim="Fraction" quantityType="Metabolite, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                            <Reaction id="DsrOAIw3F0qiIKCb6QgaYg" name="Cyp-ME" icon="Metabolism" mode="Logical" containerType="Other" dimension="Dimensionless" formula="NrKgrsKmwkiGET1q7OIPYg">
-                              <Educts>
-                                <ReactionPartner stoichiometricCoefficient="1" partner="1EnMTQCxHkmgkxQCMDxj7Q" />
-                              </Educts>
-                              <Products>
-                                <ReactionPartner stoichiometricCoefficient="1" partner="nR0eNM5wvUSyevBnZmbiyw" />
-                              </Products>
-                              <ModifierNames>
-                                <ModifierNamesChild>Cyp</ModifierNamesChild>
-                              </ModifierNames>
-                            </Reaction>
-                          </Children>
-                        </Container>
-                        <Container id="f7z66YOv_0Kv2m70sTfn_g" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Interstitial" />
-                            <Tag value="ColonDescendens" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="NmmKZumltUGxsOsPfg4x1Q" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="owgI66XQcE2ClB4BHV50ew" dim="Volume" quantityType="0" />
-                            <Parameter id="v9fwZGMOa0eYCw1FUWlzwQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="4VSppd3W3E6-12kllCJ0Mg" dim="Volume" quantityType="0" />
-                            <Parameter id="-x-U0PwhtUCEzECzEqg31g" name="pH" description="pH" persistable="0" isFixedValue="0" formula="tKjHIxsi60KoHEPhXQBZrw" dim="Dimensionless" quantityType="0" />
-                            <MoleculeAmount id="CKyJxgj_J0aXIt90lAntLg" name="Drug" icon="Drug" persistable="0" isFixedValue="0" formula="4Mz0QmjI50O02p6sO2Ojaw" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="IqqRhziUsE-fOsQDZs8XRw" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Parameter id="M5dmXea-FE2svtvFx_SxnA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="wPO3z22t0U6pxtynbexi8A" dim="Dimensionless" quantityType="0" />
-                                <Observer id="dgQdiLcBtUmbYW5jItoqiw" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Drug, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                          </Children>
-                        </Container>
-                        <Container id="fhKVy0QUsU65lCWnp-XKEw" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Intracellular" />
-                            <Tag value="ColonDescendens" />
-                            <Tag value="IntestinalSecretionSource" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="pS59tu9R60GlLBOi0knTnA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="M9arQg_qfEGMA7JdlSXkFA" dim="Volume" quantityType="0" />
-                            <Parameter id="b1N-bcyKTU2CQ95bLe6_mQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="3l84whkuX0S7xUUHglUQpg" dim="Volume" quantityType="0" />
-                            <Parameter id="YAvWv9SHYkKjk1QH-YY3hg" name="pH" description="pH" persistable="0" isFixedValue="0" formula="Tx469lVChEyenXN90mVCpw" dim="Dimensionless" quantityType="0" />
-                            <MoleculeAmount id="mEKZGg1cwkGlW7LIRKyu3Q" name="Drug" icon="Drug" persistable="0" isFixedValue="0" formula="siwAEB7fgEaOdy8LH-L5WA" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="TZibvnbS30iqapO5i4GYqQ" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Parameter id="2Frf8dZ3f0a7htvtJUyRhA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="1c5nbJqYlUmurzUd7msH3A" dim="Dimensionless" quantityType="0" />
-                                <Observer id="C2x7QxfdyECk116PgDUQTw" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Drug, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                            <MoleculeAmount id="lIAu75GPMEiLLHCJI2QdNA" name="Cyp" icon="Enzyme" persistable="0" isFixedValue="0" formula="wb5yCXJZxUeVY_7iSBmoSg" dim="Amount" quantityType="Enzyme" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="Wx7OuGDAgkCsCINMZckU9w" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" formula="mEC3JUe6f0qBE0PI4vN6WQ" dim="Dimensionless" quantityType="0" />
-                                <Parameter id="OkQg6L2yA0iRPIFkpbWu1Q" name="Relative expression out." description="Relative Expression that will be used in the simulation" persistable="0" isFixedValue="0" formula="GtBZCb_uvUKgURPKDkyZKA" dim="Fraction" quantityType="0" />
-                                <Parameter id="YRmPj1s5jkOxEslcAvKvkQ" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" persistable="0" isFixedValue="0" formula="7rQWrpuJJESEIEetDBlQqA" dim="Fraction" quantityType="0" />
-                                <Parameter id="gijxg3SDF0ylIHZSGjFHqQ" name="Relative expression" description="Relative expression" persistable="0" isFixedValue="0" formula="pRgR8QWtkEC4Lj-8LhDblw" dim="Fraction" quantityType="0" />
-                                <Parameter id="S0x9xoJSF0-j0BIUIFioTw" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Observer id="mEzE1-qlzkSGKwj7Mnhg1A" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Enzyme, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                            <MoleculeAmount id="KPlEtuj9AUO856qyTA6x-g" name="Drug-Cyp Metabolite" persistable="0" isFixedValue="0" formula="swbBobQ4D0uqiWiex7tAsw" dim="Amount" quantityType="Metabolite" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="YfqbFxmOPEWSjiupy7U9Cw" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Observer id="R5aRnv8MbEGbcY7cTCElZw" name="Fraction of dose" description="Metabolized fraction of administered dose" persistable="1" isFixedValue="0" formula="aUoTQ3n3a0OShljd8bUj3w" dim="Fraction" quantityType="Metabolite, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                            <Reaction id="Li0ryniH10OIPPb5pGn8Sw" name="Cyp-ME" icon="Metabolism" mode="Logical" containerType="Other" dimension="Dimensionless" formula="NrKgrsKmwkiGET1q7OIPYg">
-                              <Educts>
-                                <ReactionPartner stoichiometricCoefficient="1" partner="mEKZGg1cwkGlW7LIRKyu3Q" />
-                              </Educts>
-                              <Products>
-                                <ReactionPartner stoichiometricCoefficient="1" partner="KPlEtuj9AUO856qyTA6x-g" />
-                              </Products>
-                              <ModifierNames>
-                                <ModifierNamesChild>Cyp</ModifierNamesChild>
-                              </ModifierNames>
-                            </Reaction>
-                          </Children>
-                        </Container>
-                      </Children>
-                    </Container>
-                    <Container id="Jwt4w8vvkkqrvNRBqyhbQQ" name="ColonSigmoid" description="Colon Sigmoid / Distal Colon 2" icon="ColonSigmoid" mode="Logical" containerType="Compartment">
-                      <Tags>
-                        <Tag value="ColonSigmoid" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="xOiZ5CK5RESQhR7-J_EmNg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="1F4ywShGdk-NIiIwwDm0eg" dim="Volume" quantityType="0" />
-                        <Parameter id="R5cRaYh9JUivNTyoRr-adg" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" formula="kwODwvzO2EmwsfpoqtwdYg" dim="Volume" quantityType="0" />
-                        <Parameter id="qON1dJtW3kGBuu2nk4-nAw" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" formula="6e9LHlTFJkG-PMFyieazhw" dim="Flow (volume)" quantityType="0" />
-                        <Parameter id="ZlS0Wol6iE-QJPSl1BMTiQ" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" formula="hB48fjDKB0aPhnPyDobY9g" dim="Flow (volume)" quantityType="0" />
-                        <Parameter id="O5JaPuJ6x069MyJ2vPDSag" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" formula="PSbm5ReMbUKRj9xRJC3ccA" dim="Flow (volume)" quantityType="0" />
-                        <Parameter id="3QaJgAc7EkuTJ1wi1UmLpQ" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" formula="FbGzbaLst0K5o2gc_gSjaQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="soeNfkCu0k-Bx99KUR1MKw" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" formula="gzxo9hM0e0S00i0f9_W4bg" dim="Density" quantityType="0" />
-                        <Parameter id="lC_Fd99JjUKJ6hKiKerLkg" name="Fraction mucosa" description="Mucosal fraction of regional intestinal tissue mass" persistable="0" isFixedValue="0" formula="cEM4sJwEiEK3tke4NRLLlg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="PEPrfB_LZUGhbF9A79XQtw" name="Fraction of regional blood flow rate" description="Regional blood flow fraction supplying the mucosal tissue of the segment" persistable="0" isFixedValue="0" formula="Ju_X-QA330CVU7vSWfEQnQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="VroiKowI_EG_5u_xEraMGw" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" formula="pSoZfUh-JkaHvw9t9tcfAw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="dS8yKFWFakqLnxV56jJsYg" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" formula="uWe9jIOw006XNv1YZjNubA" dim="Nanolength" quantityType="0" />
-                        <Parameter id="FGdKMhPzyUSmkDoSsNVcGg" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" formula="ckBKkjov2kusoQly5ZUmYg" dim="Nanolength" quantityType="0" />
-                        <Parameter id="qIMtBwf8L0K9M1eDt3j5tQ" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" formula="ROxB3D7SE0CZSpRfI6SqeA" dim="HydraulicConductivity" quantityType="0" />
-                        <Parameter id="rZF1-Q_BX027pY6QB7_hWg" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" formula="D3VPWAoyk0q6n-AXWhqPOA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="nK9tS12scUiMm-tcwN7mwg" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="MVTEUXI_50m_b5r-Qg2aDA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="1_bYtrzKzkCgVaprRt2l3Q" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="zUoSCkPvX0OU8HDKJtiN4Q" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="Y-rnKltqrkGsywrKV6AzFg" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" formula="YoG91MEaNU-lH7bDuqdNAA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="P5mmGZwZjEi5BgF4OU-LnA" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="_hC2k_aci0ievGnQhNw1qA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="2HEw02dkTUSYxs3pBC3bVw" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="zayFcqcXqkO1zqnHyTeJ_w" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="JVsy-v6_CEOt-oJ82enOQQ" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="otjhm_2UaUmchVaIcXh3jA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="mNjYhL7_jEy5LpReJiuaEA" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="eubNi3n7YUuXQI6EbKECuQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="wL-9bS28bkS4uOc3T0VU5A" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="QOgNXhX1I069pFcAlpbZbQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="HV3xMUd_3EeLHaQTWUKHgw" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="FxmVEiaeM0i8H2KT7-E2dQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="yg310dLHd0-0-Di3rfd0nQ" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="w2uP6bpgS0m7AGRw77b3TA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="hsyvz3_VyUmJ6YPcyaFR5w" name="Microsomal protein mass/g tissue" description="Microsomal protein content per gram tissue" persistable="0" isFixedValue="0" formula="SE0q0hU55UC3zDnbt9GoqA" dim="MassProteinPerTissue" quantityType="0" />
-                        <Parameter id="nQhPeITZaki6wIWYKUhH2A" name="Number of cells/g tissue" description="Number of cells per gram tissue" persistable="0" isFixedValue="0" formula="S0x5Cw3Po0ia70182fHakw" dim="CellQuantityPerTissue" quantityType="0" />
-                        <Parameter id="uMx7BeknZkW5oQPwHCc07A" name="Protein mass/g tissue" description="Total protein content per gram tissue" persistable="0" isFixedValue="0" formula="7bOporE8c0mpvgT9IscFxw" dim="MassProteinPerTissue" quantityType="0" />
-                        <Parameter id="ZjZXGwgi1UaZqaQ5bUA_pw" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" formula="yogmoaojaU6uCJ5crMxXsw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="w1PnOQnQDkOQIQmonu7JsQ" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="lMT7A43sWEWhA3KPChMKpg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="kPQDWgb4Rkq2abGpOKm9Sw" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="-dgHgwY-eUm2FKGcWcgA4g" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="n7rpyrzsC0yXl28MI-IigA" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="N9XRI61eTkCUV3_ZTpDJ9g" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="ccecCOarB0ep8aoAWrQsPg" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="UtVQBrQ0s0qZh83Wr0NG7w" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="3RAFHyEpS0-voH2uheSMpg" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="vKy1nGbogEK5-ChpBM2QwA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="z7z4zD6ySU2Kpe6V5RYH4w" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="XLgQ3Qsihk2j-RDDCYJiPQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="ZHn5PwHgF0ypnS9Wp7WXkQ" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="u8J6WsYi4UufhBK8iXaBEQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="E63tbOSXokOxyu7j2gI1CA" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="mzKQ6KoBFkqm1zZqI6A1-Q" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="32enPLdAO0KzPzDJhaZ_qw" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="zm9dCX7YWEajFWAWR2BJyw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="FEi0FLJU8Uu5vhE1EDkJIg" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="TRuJAvtL70S5sV1kxqjX0g" dim="Dimensionless" quantityType="0" />
-                        <Container id="OueVYReP4UKcfdpQe9-xDg" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Plasma" />
-                            <Tag value="ColonSigmoid" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="3nAKz7AgG0auES7RCn8Heg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="owgI66XQcE2ClB4BHV50ew" dim="Volume" quantityType="0" />
-                            <Parameter id="HJhk5UZ87keBeS2VACQNaw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="rbp4e7PXpUyuD1ZtA8Ocxw" dim="Volume" quantityType="0" />
-                            <MoleculeAmount id="Ecj_rn201Uq4oPkYy48ZIA" name="Drug" icon="Drug" persistable="0" isFixedValue="0" formula="NX6TpumeCUy2CtBHdV6hpA" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="obZOS7kP-EWJwz40OK-9GA" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Parameter id="UU7hIVwerUaXUtwGe_SsYA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="juH_s5qMqE-veNdva1_Ufg" dim="Dimensionless" quantityType="0" />
-                                <Observer id="wizOF66RtUmK8_XrEE3hNQ" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Drug, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                            <MoleculeAmount id="Fndt9v8wH0a5KC_oGbJ2FQ" name="Cyp" icon="Enzyme" persistable="0" isFixedValue="0" formula="wb5yCXJZxUeVY_7iSBmoSg" dim="Amount" quantityType="Enzyme" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="5MHBuk4NM0WcXZJgJDmGuA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" formula="YgtlyfN4hU6jOU2tzMS4Wg" dim="Dimensionless" quantityType="0" />
-                                <Parameter id="DLAXndpZRUucQxkKM_krwQ" name="Relative expression out." description="Relative Expression that will be used in the simulation" persistable="0" isFixedValue="0" formula="GtBZCb_uvUKgURPKDkyZKA" dim="Fraction" quantityType="0" />
-                                <Parameter id="R4AmzlxICUuqwgPHNYRrtQ" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" persistable="0" isFixedValue="0" formula="Qv2OyMi-nU-kPqJ48WVuVw" dim="Fraction" quantityType="0" />
-                                <Parameter id="S_tlHxZd906HtGasIwFirQ" name="Relative expression" description="Relative expression" persistable="0" isFixedValue="0" formula="iUzjEbj_NkSh4u8TNBhFgQ" dim="Fraction" quantityType="0" />
-                                <Parameter id="JBB5YlPMcE2rbzkGr7h9xQ" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Observer id="Qc31gqejLEmej_YM_WB25A" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Enzyme, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                            <MoleculeAmount id="_G4g8vSqvE-OabC1r23xvA" name="Drug-Cyp Metabolite" persistable="0" isFixedValue="0" formula="9qtv07KbMkG4tOKC3OCiHg" dim="Amount" quantityType="Metabolite" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="zxMsYGlOPk6ByAykNizBRQ" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Observer id="xLG83eSGNUaYViKgSX0bcw" name="Fraction of dose" description="Metabolized fraction of administered dose" persistable="1" isFixedValue="0" formula="aUoTQ3n3a0OShljd8bUj3w" dim="Fraction" quantityType="Metabolite, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                            <Reaction id="4YQoIq-0mkqhUKbO3xygKg" name="Cyp-ME" icon="Metabolism" mode="Logical" containerType="Other" dimension="Dimensionless" formula="NrKgrsKmwkiGET1q7OIPYg">
-                              <Educts>
-                                <ReactionPartner stoichiometricCoefficient="1" partner="Ecj_rn201Uq4oPkYy48ZIA" />
-                              </Educts>
-                              <Products>
-                                <ReactionPartner stoichiometricCoefficient="1" partner="_G4g8vSqvE-OabC1r23xvA" />
-                              </Products>
-                              <ModifierNames>
-                                <ModifierNamesChild>Cyp</ModifierNamesChild>
-                              </ModifierNames>
-                            </Reaction>
-                          </Children>
-                        </Container>
-                        <Container id="VFAajW768UeoKlpXQfnVNA" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="BloodCells" />
-                            <Tag value="ColonSigmoid" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="XMgdHjlQZkSFmG-tY-Dwzg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="owgI66XQcE2ClB4BHV50ew" dim="Volume" quantityType="0" />
-                            <Parameter id="sx6teYDZK0ijsIPXmtHTUA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="tFZiRJ-Sv0qf0gsV7ycmYw" dim="Volume" quantityType="0" />
-                            <MoleculeAmount id="bftHsV58IEij5P2Nw6mjNA" name="Drug" icon="Drug" persistable="0" isFixedValue="0" formula="AklF1iW02U-UojSSbKYGLw" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="-kT0fCjh70uWhLFdE9CifA" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Parameter id="UrGqZq0yoUqKX3nTCp4g1Q" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="ozkzB2bMIE-niFwSHecpDQ" dim="Dimensionless" quantityType="0" />
-                                <Observer id="7o-ou9Ay4kmHthvf-FNXlg" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Drug, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                            <MoleculeAmount id="BdpqUl0zsE6XIKTpS1zpog" name="Cyp" icon="Enzyme" persistable="0" isFixedValue="0" formula="wb5yCXJZxUeVY_7iSBmoSg" dim="Amount" quantityType="Enzyme" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="-m97uMieiEurNjp0kPdO0w" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" formula="-rdafvCHS06rcLOngJKbZQ" dim="Dimensionless" quantityType="0" />
-                                <Parameter id="cWR9oV6Clki9uWzAvWylnA" name="Relative expression out." description="Relative Expression that will be used in the simulation" persistable="0" isFixedValue="0" formula="GtBZCb_uvUKgURPKDkyZKA" dim="Fraction" quantityType="0" />
-                                <Parameter id="li-N_FXWAk6DlxTzDzao-g" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" persistable="0" isFixedValue="0" formula="FTxLv_b4CkKigLwWdcA4xg" dim="Fraction" quantityType="0" />
-                                <Parameter id="20Kn5unCXk-trI2QLuoT5A" name="Relative expression" description="Relative expression" persistable="0" isFixedValue="0" formula="_J3C13ewoUatoCS2w-zxeg" dim="Fraction" quantityType="0" />
-                                <Parameter id="aKd6TtoX-0uGARCWzc3W5Q" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Observer id="zNd9FqBOwUKaqRFyRHLzig" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Enzyme, Observer" />
-                              </Children>
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-                            <MoleculeAmount id="VOHL82SY6UyALAMEXNWvbA" name="Drug-Cyp Metabolite" persistable="0" isFixedValue="0" formula="Fvk6VXmP90aJ_89OdgUS_g" dim="Amount" quantityType="Metabolite" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="Qdes3al4CUe9HfF25vxoNA" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Observer id="qEwJixnPVEmEeuzhhaksFA" name="Fraction of dose" description="Metabolized fraction of administered dose" persistable="1" isFixedValue="0" formula="aUoTQ3n3a0OShljd8bUj3w" dim="Fraction" quantityType="Metabolite, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                            <Reaction id="Nn-kg-NlY0el6cHV0oS92g" name="Cyp-ME" icon="Metabolism" mode="Logical" containerType="Other" dimension="Dimensionless" formula="NrKgrsKmwkiGET1q7OIPYg">
-                              <Educts>
-                                <ReactionPartner stoichiometricCoefficient="1" partner="bftHsV58IEij5P2Nw6mjNA" />
-                              </Educts>
-                              <Products>
-                                <ReactionPartner stoichiometricCoefficient="1" partner="VOHL82SY6UyALAMEXNWvbA" />
-                              </Products>
-                              <ModifierNames>
-                                <ModifierNamesChild>Cyp</ModifierNamesChild>
-                              </ModifierNames>
-                            </Reaction>
-                          </Children>
-                        </Container>
-                        <Container id="tp-AgqcxjUix4Bk1CBNHOA" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Interstitial" />
-                            <Tag value="ColonSigmoid" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="kyL1IG3pu0i_i1Z-HQy5-g" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="owgI66XQcE2ClB4BHV50ew" dim="Volume" quantityType="0" />
-                            <Parameter id="dMuOfrNhxUe6rDMzabzbiQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="4VSppd3W3E6-12kllCJ0Mg" dim="Volume" quantityType="0" />
-                            <Parameter id="Cdqzrqe45km5h7Xp6uVYjg" name="pH" description="pH" persistable="0" isFixedValue="0" formula="tKjHIxsi60KoHEPhXQBZrw" dim="Dimensionless" quantityType="0" />
-                            <MoleculeAmount id="Mn9QFm9qE0SmdJIL6qjaHg" name="Drug" icon="Drug" persistable="0" isFixedValue="0" formula="wHFF8bmALkq7GZ_vGY1smQ" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="A7_YOMYQRUiGWQZU6JlqOA" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Parameter id="-c9z7b8s7UOKjJ4wdTcXKg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="Q-_evgFyf0u-VHs0BodYwg" dim="Dimensionless" quantityType="0" />
-                                <Observer id="1vVXeeOei0mvD2Cze58xXw" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Drug, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                          </Children>
-                        </Container>
-                        <Container id="S-Xf7WF0J0CfyWoC5jZgyQ" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Intracellular" />
-                            <Tag value="ColonSigmoid" />
-                            <Tag value="IntestinalSecretionSource" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="FaqckwrpuUaAcFcG-rZcNw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="M9arQg_qfEGMA7JdlSXkFA" dim="Volume" quantityType="0" />
-                            <Parameter id="CaV2JY94UEG9Klz1KkDJpw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="3l84whkuX0S7xUUHglUQpg" dim="Volume" quantityType="0" />
-                            <Parameter id="abLhX4d6T0CQcyc5ICqTcg" name="pH" description="pH" persistable="0" isFixedValue="0" formula="fnBx51dH3ESU150eG12bZA" dim="Dimensionless" quantityType="0" />
-                            <MoleculeAmount id="Q3pUr_-iP0yK59PkKUaZsA" name="Drug" icon="Drug" persistable="0" isFixedValue="0" formula="SyHSg1NbYEeKf7L83c2VRw" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="zUBgupY49UiWAt_ywaJ1wA" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Parameter id="gUXR-jYoxUSqM2BBZkkkug" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="uvAtKXL0KUq8kK21cdrunA" dim="Dimensionless" quantityType="0" />
-                                <Observer id="7a1l4sFOy02dmMwTyk_EKg" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Drug, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                            <MoleculeAmount id="EfDcV-qftE29sXGN2lwI2A" name="Cyp" icon="Enzyme" persistable="0" isFixedValue="0" formula="wb5yCXJZxUeVY_7iSBmoSg" dim="Amount" quantityType="Enzyme" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="Fk-w_r9UT0igEgvbj0_m_A" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" formula="Ox27YcQwekmjo1Bvmv4TkQ" dim="Dimensionless" quantityType="0" />
-                                <Parameter id="XBuYlsXi40qRZVr9MCqlOA" name="Relative expression out." description="Relative Expression that will be used in the simulation" persistable="0" isFixedValue="0" formula="GtBZCb_uvUKgURPKDkyZKA" dim="Fraction" quantityType="0" />
-                                <Parameter id="FcbLgWdbvk-VZU3ILiY6yw" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" persistable="0" isFixedValue="0" formula="qtrbtx_TTE-_syinxnlOLg" dim="Fraction" quantityType="0" />
-                                <Parameter id="jvGT0cKDHUu0iG05A71y9A" name="Relative expression" description="Relative expression" persistable="0" isFixedValue="0" formula="w-tWe3kbmkS4I0tNmz5eOQ" dim="Fraction" quantityType="0" />
-                                <Parameter id="LnFuTAK1l0-RYoq-KGBt7g" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Observer id="kf1Uu1gLPU2sMnv4LMV-FA" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Enzyme, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                            <MoleculeAmount id="0Nt9A3bwmkKoqF_CBz3zgw" name="Drug-Cyp Metabolite" persistable="0" isFixedValue="0" formula="hE0c8N7GiUy-Z5PYxgSXUg" dim="Amount" quantityType="Metabolite" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="PSADQrEw8UeBOWyw8Ou8gA" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Observer id="eJnNkKFmFUaGxq4n2gvl2g" name="Fraction of dose" description="Metabolized fraction of administered dose" persistable="1" isFixedValue="0" formula="aUoTQ3n3a0OShljd8bUj3w" dim="Fraction" quantityType="Metabolite, Observer" />
-                              </Children>
-                            </MoleculeAmount>
-                            <Reaction id="bGJZa5kB2kakn1DIL5ZVGg" name="Cyp-ME" icon="Metabolism" mode="Logical" containerType="Other" dimension="Dimensionless" formula="NrKgrsKmwkiGET1q7OIPYg">
-                              <Educts>
-                                <ReactionPartner stoichiometricCoefficient="1" partner="Q3pUr_-iP0yK59PkKUaZsA" />
-                              </Educts>
-                              <Products>
-                                <ReactionPartner stoichiometricCoefficient="1" partner="0Nt9A3bwmkKoqF_CBz3zgw" />
-                              </Products>
-                              <ModifierNames>
-                                <ModifierNamesChild>Cyp</ModifierNamesChild>
-                              </ModifierNames>
-                            </Reaction>
-                          </Children>
-                        </Container>
-                      </Children>
-                    </Container>
-                    <Container id="9PViAFuCokS1bTJ4N_5gmA" name="Rectum" description="Rectum" icon="Rectum" mode="Logical" containerType="Compartment">
-                      <Tags>
-                        <Tag value="Rectum" />
-                      </Tags>
-                      <Children>
-                        <Parameter id="m2WBnUyD1UGNthvRpIBaTA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="kQcoIxbX70S4AkaZB4T49w" dim="Volume" quantityType="0" />
-                        <Parameter id="kZ5io-ADzkK5WtOSwdGuwg" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" formula="SNxq7u6ab0CIYMd_ttLZ6Q" dim="Volume" quantityType="0" />
-                        <Parameter id="JqnYmj5Lrke-kCjVFWXO0g" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" formula="hB48fjDKB0aPhnPyDobY9g" dim="Flow (volume)" quantityType="0" />
-                        <Parameter id="iVcy2Efehk62dgOO6rnaBg" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" formula="6e9LHlTFJkG-PMFyieazhw" dim="Flow (volume)" quantityType="0" />
-                        <Parameter id="wIrwjhYhrkqp9H1aJgeydA" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" formula="PSbm5ReMbUKRj9xRJC3ccA" dim="Flow (volume)" quantityType="0" />
-                        <Parameter id="jBD3VqvCL0eMq0NOtAsXow" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" formula="FbGzbaLst0K5o2gc_gSjaQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="YmU_XDAR7EevENS08BXvrA" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" formula="uM8iofysCEq9hZA8iqm2JQ" dim="Density" quantityType="0" />
-                        <Parameter id="BGP5opyaukSAamLzlZ4fGA" name="Fraction of regional blood flow rate" description="Regional blood flow fraction supplying the mucosal tissue of the segment" persistable="0" isFixedValue="0" formula="MrGxUq953UyHD63PjkuBcg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="-eymXpRMFUuTrtA5ZkvnnQ" name="Fraction mucosa" description="Mucosal fraction of regional intestinal tissue mass" persistable="0" isFixedValue="0" formula="1oL3ASowTkapHBu1h68Bgg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="caR_dzvQR06KfWLUBCgTrw" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" formula="MNqEskR9tECGL1he2wsbxg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="pdxSgynV0Uug8A4tHyOpEg" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" formula="uhxbmoGZjE2ZEqi-hsBtjw" dim="Nanolength" quantityType="0" />
-                        <Parameter id="q3-H2x8K7Uar6UxP9DsmYw" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" formula="LUtUQXsenUq4X3dRLS2AdQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="PHDuGVceGEWHcGD4mqLfFQ" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" formula="g0iiyKKAMU6vKrMethA3xQ" dim="HydraulicConductivity" quantityType="0" />
-                        <Parameter id="Mxw1Ck0GIU2kAz4KxDUxGg" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" formula="IusF0L1jhEOmhb16tm0vqw" dim="Nanolength" quantityType="0" />
-                        <Parameter id="ry72T63OdEGdDTzz7usNyw" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="uqpbgHfZsU2_LTgg6Ip2_Q" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="hAdUD1DyHECr_AlSX44dmQ" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="QD_YQuy6IEOArSd4CuINXA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="8xhBx4bcRUmbKMY7-E_B6g" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" formula="O5CYCepfNEu-AFzjJB3Veg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="jk21YlhohkegEO7xhTNXbA" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="K4x71b_UTU6FsfN7UpvaYQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="Od7r2s46s0Sbw10qGvHQOg" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="M8nrJnCcgUy6F2quIb8IXw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="bxduchFT_EeLEEoeCNPLxg" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="HORHkwhfIUeyGl9JraENqQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="YMiUmOmGjkyvWEYVZabv1w" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="Aa4AuODxikCE_Cxp0P5iOw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="esn9ED2DAEm4vmmJRmZAYA" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="zcyTWHbLa0SuDe78iVHEtw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="Q0TvpQwlTE-P3pO25hr3Mg" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="6W0COJYosUem1izcrhXcVA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="_dfNDEDbLUuVguGTOBhHkg" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="VlZGcZOi8kCwSJTG03bgsw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="g5_4PKggt0WF-HqOg_yA8g" name="Protein mass/g tissue" description="Total protein content per gram tissue" persistable="0" isFixedValue="0" formula="38w6SRwAckKGVqbrPDM98A" dim="MassProteinPerTissue" quantityType="0" />
-                        <Parameter id="rpw8WPun-EqwOQrTAixJyQ" name="Number of cells/g tissue" description="Number of cells per gram tissue" persistable="0" isFixedValue="0" formula="iSUcwXGfxkyqdVZ9WC84uQ" dim="CellQuantityPerTissue" quantityType="0" />
-                        <Parameter id="QzU8Uc6zpkGSJ8kLVTWoUQ" name="Microsomal protein mass/g tissue" description="Microsomal protein content per gram tissue" persistable="0" isFixedValue="0" formula="HogBvl-L5EWBTkbd0RyHHQ" dim="MassProteinPerTissue" quantityType="0" />
-                        <Parameter id="FMK9v0Ycf0m5WyRztukVkg" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" formula="wCGZJtnVoUWdJ63A2D-8Tg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="Yx_NpkQoRk2KqGmZUieCew" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="UvJJzT72_0amedM-heb6gg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="Dj-A0NZ8C0WvfawYOkzGEw" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="T0kRvdF09ESD8pV7N6_Rkw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="unNb5484qkW86V4L1W9J3A" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="pj0r6sdidkqvCW6MoyEyqw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="nZEs5Ishm0WUVSUP0kQilQ" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="kP4jgpBd0EmdmKviHEvhjg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="ZlfPv3s7AUeZvKdByiFGWg" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="OAMPeFMMgkebZ5lCG4OR3A" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="onQz7k74gku6V71FsGTw3A" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="7QtScXHMmE2PwPXb4XuSNg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="oWTLdpo5aUyj5Lwcu4l-Dw" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="mRmqcRYVHEqTw_LTYIdxjg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="5cOOV9eNIkau_xUp1gt2Ng" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="IIlD16BxaUaW3S0L4pO3Tg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="H12JPEevrUOcm_VGU_TeDQ" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="SAbf82Th6EKSURMh5p86VQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="B8hY1K6TGUub5gPm17jHjQ" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="rXxHcDFglkSpKGJ6gT0mlQ" dim="Dimensionless" quantityType="0" />
-                        <Container id="zhw7k9aVu0eeZFACLC99xw" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Plasma" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                            <Tag value="Rectum" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="vAwtsqe7fEmjatQeX1RQ3A" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="owgI66XQcE2ClB4BHV50ew" dim="Volume" quantityType="0" />
-                            <Parameter id="5SR2h8rg2kaV0YMaAMPoFA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="rbp4e7PXpUyuD1ZtA8Ocxw" dim="Volume" quantityType="0" />
-                            <MoleculeAmount id="r7ItQnvBJ0efZqobBY36mQ" name="Drug" icon="Drug" persistable="0" isFixedValue="0" formula="EXzEyOGUfkqRbUcZ9pmYCw" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1">
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-                                <Parameter id="L7Mhpxk0kk62yfkcJ6lQwA" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Parameter id="E5fZzRIGskC0KNWSEbJUjQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="17zINWWMqEq5k1kiOQsXyQ" dim="Dimensionless" quantityType="0" />
-                                <Observer id="iLQ0j3KyBEWrCxTrDX5ghQ" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Drug, Observer" />
-                              </Children>
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-                            <MoleculeAmount id="vR2TPKNB0UyT2u1njPhiOg" name="Cyp" icon="Enzyme" persistable="0" isFixedValue="0" formula="wb5yCXJZxUeVY_7iSBmoSg" dim="Amount" quantityType="Enzyme" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="j9uOxlnS0Uy0dOIQ3YkhjQ" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" formula="5vDfNUDNikW2ZOwLStNTWw" dim="Dimensionless" quantityType="0" />
-                                <Parameter id="cawoopGjA0ODbKciuvo_Vg" name="Relative expression out." description="Relative Expression that will be used in the simulation" persistable="0" isFixedValue="0" formula="GtBZCb_uvUKgURPKDkyZKA" dim="Fraction" quantityType="0" />
-                                <Parameter id="qCaoz-u7nECW8SzSV4VX4g" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" persistable="0" isFixedValue="0" formula="Qv2OyMi-nU-kPqJ48WVuVw" dim="Fraction" quantityType="0" />
-                                <Parameter id="Yf-pFDK9Gkqyt4E__Doy0Q" name="Relative expression" description="Relative expression" persistable="0" isFixedValue="0" formula="iUzjEbj_NkSh4u8TNBhFgQ" dim="Fraction" quantityType="0" />
-                                <Parameter id="UfcVg_tE20q9qbxuvS2Rag" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Observer id="Xmf6DR1ToUa6LJW9DfcAng" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Enzyme, Observer" />
-                              </Children>
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-                            <MoleculeAmount id="Jgx2T3MD60SbNNZKXQtR0Q" name="Drug-Cyp Metabolite" persistable="0" isFixedValue="0" formula="9t4GWWLClEGs4poZoxH0Tw" dim="Amount" quantityType="Metabolite" mode="Logical" scaleFactor="1">
-                              <Children>
-                                <Parameter id="7_-ye4btoUCpgHHBQvMVCw" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Observer id="OjzW6-lSG0uWi7kGBu66AA" name="Fraction of dose" description="Metabolized fraction of administered dose" persistable="1" isFixedValue="0" formula="aUoTQ3n3a0OShljd8bUj3w" dim="Fraction" quantityType="Metabolite, Observer" />
-                              </Children>
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-                            <Reaction id="ww_tKtKaoUy5F-NBumIIBg" name="Cyp-ME" icon="Metabolism" mode="Logical" containerType="Other" dimension="Dimensionless" formula="NrKgrsKmwkiGET1q7OIPYg">
-                              <Educts>
-                                <ReactionPartner stoichiometricCoefficient="1" partner="r7ItQnvBJ0efZqobBY36mQ" />
-                              </Educts>
-                              <Products>
-                                <ReactionPartner stoichiometricCoefficient="1" partner="Jgx2T3MD60SbNNZKXQtR0Q" />
-                              </Products>
-                              <ModifierNames>
-                                <ModifierNamesChild>Cyp</ModifierNamesChild>
-                              </ModifierNames>
-                            </Reaction>
-                          </Children>
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-                        <Container id="MFTNPY8lYUuHI3TkYqAe_Q" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="BloodCells" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                            <Tag value="Rectum" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="n5-gMYbmzEigmN87-34yHQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="owgI66XQcE2ClB4BHV50ew" dim="Volume" quantityType="0" />
-                            <Parameter id="cFxSSriCI0GRvqXZtFyJXA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="tFZiRJ-Sv0qf0gsV7ycmYw" dim="Volume" quantityType="0" />
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-                                <Parameter id="k1G5dMyURk6_hIpFw69S1Q" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                                <Parameter id="BOUQEYIfz0Sv37IUVGtXBQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="3A4JwxYP8UiNNj7zTMqkDQ" dim="Dimensionless" quantityType="0" />
-                                <Observer id="VfdrK24ghk6907WZlVS4LQ" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Drug, Observer" />
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-                              <Children>
-                                <Parameter id="4KoywVf1fEmelSqlG4IVIA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" formula="Gx1Cbdfof0K3ieW6knsp1A" dim="Dimensionless" quantityType="0" />
-                                <Parameter id="02JidD4Xh0-hdBYiduZtGw" name="Relative expression out." description="Relative Expression that will be used in the simulation" persistable="0" isFixedValue="0" formula="GtBZCb_uvUKgURPKDkyZKA" dim="Fraction" quantityType="0" />
-                                <Parameter id="kVfY1HQjpEeSMqiqnezqLw" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" persistable="0" isFixedValue="0" formula="FTxLv_b4CkKigLwWdcA4xg" dim="Fraction" quantityType="0" />
-                                <Parameter id="8PqsOEq1yEmgcO0CRPUdAg" name="Relative expression" description="Relative expression" persistable="0" isFixedValue="0" formula="_J3C13ewoUatoCS2w-zxeg" dim="Fraction" quantityType="0" />
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-                                <Parameter id="Bd3RFrBj7E-7ATcwcl9Mmw" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
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-                            <Reaction id="jt0Vrq5pgkm9JqT427190w" name="Cyp-ME" icon="Metabolism" mode="Logical" containerType="Other" dimension="Dimensionless" formula="NrKgrsKmwkiGET1q7OIPYg">
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-                        <Container id="8Dqh8-N8EkePTw3n4M3mxA" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Interstitial" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                            <Tag value="Rectum" />
-                          </Tags>
-                          <Children>
-                            <Parameter id="JUoL3_ZPOk-5JCcurODQoQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="owgI66XQcE2ClB4BHV50ew" dim="Volume" quantityType="0" />
-                            <Parameter id="8wKuIRpXXkS_vlL48nlGrw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="4VSppd3W3E6-12kllCJ0Mg" dim="Volume" quantityType="0" />
-                            <Parameter id="psaFTvMpxkeaZ9sSv-WzUA" name="pH" description="pH" persistable="0" isFixedValue="0" formula="tKjHIxsi60KoHEPhXQBZrw" dim="Dimensionless" quantityType="0" />
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-                                <Parameter id="TgSxBP1vB0WYZWcByJWA-g" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="pIOSkaB0-UWaDQrkTk3s3w" dim="Dimensionless" quantityType="0" />
-                                <Observer id="kmH01NrUYUCsYH9bFlsDIQ" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Drug, Observer" />
-                              </Children>
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-                        <Container id="HFtHaV0v7kCC7nIjLb3r1w" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
-                          <Tags>
-                            <Tag value="Intracellular" />
-                            <Tag value="IntestinalSecretionSource" />
-                            <Tag value="LargeIntestineSegment" />
-                            <Tag value="Mucosa" />
-                            <Tag value="Rectum" />
-                          </Tags>
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-                            <Parameter id="YzEj1ulEaUG0ruzLrqevPA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="M9arQg_qfEGMA7JdlSXkFA" dim="Volume" quantityType="0" />
-                            <Parameter id="vZNKjNppRUKTD816ibHWnA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="3l84whkuX0S7xUUHglUQpg" dim="Volume" quantityType="0" />
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-                                <Parameter id="uEe_zmCZR0uG6D45rCUx2g" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
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-                                <Parameter id="qztLn5W7jEaFVmOmIJt-BA" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" persistable="0" isFixedValue="0" formula="uI4RcBntfU6_ipJa6VET1w" dim="Fraction" quantityType="0" />
-                                <Parameter id="sb31OmHCg02vNySpcHtfeg" name="Relative expression" description="Relative expression" persistable="0" isFixedValue="0" formula="wcrXLwe7kUmHHNstGSFibg" dim="Fraction" quantityType="0" />
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-                                <Parameter id="B_DEsUaPx0CLIFjzD-sajw" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
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-                              <Educts>
-                                <ReactionPartner stoichiometricCoefficient="1" partner="Q-WHhoDEmkCqkRQKuB9hMQ" />
-                              </Educts>
-                              <Products>
-                                <ReactionPartner stoichiometricCoefficient="1" partner="K0RHSiHvAUu_yGnAKRm5wA" />
-                              </Products>
-                              <ModifierNames>
-                                <ModifierNamesChild>Cyp</ModifierNamesChild>
-                              </ModifierNames>
-                            </Reaction>
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-                </Container>
-                <Container id="FGM0B7XbGUKI1PdoKxG8BQ" name="Drug" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Observer id="b4bnfpIlYEG_mYso2GJoGg" name="Interstitial Unbound" description="Interstitial Unbound" persistable="1" isFixedValue="0" formula="sb2EI4hIhEWxy5ZYMY2QFw" dim="MolarConcentration" quantityType="Drug, Observer" />
-                    <Observer id="FBbFKDoe4EavosWZH9pPtw" name="Intracellular Unbound" description="Intracellular Unbound" persistable="1" isFixedValue="0" formula="F5kFVlFTnEmJToE6fKssfA" dim="MolarConcentration" quantityType="Drug, Observer" />
-                    <Observer id="sbp-o1aHnUWzJjC_rQgI6g" name="Total Tissue (Large Intestine)" description="Mucosa and nonmucosa tissue" persistable="1" isFixedValue="0" formula="c-W_QUNGZkC3n7yt82JPWQ" dim="MolarConcentration" quantityType="Drug, Observer" />
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-              </Children>
-            </Container>
-            <Container id="qgF1sCkjDUOX4lXyHomjfw" name="Liver" description="Liver" icon="Liver" mode="Logical" containerType="Organ">
-              <Tags>
-                <Tag value="Liver" />
-                <Tag value="TissueOrgan" />
-              </Tags>
-              <Children>
-                <Parameter id="vjSgqLrn-keAen-YkY4T6A" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" formula="-DFwPBr6-EuB8kn5DzuHRw" dim="Volume" quantityType="0" />
-                <Parameter id="0QvwGIVJv0WRy-YDEjBszA" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" formula="FbGzbaLst0K5o2gc_gSjaQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="yDzsWSFOv06xIbHsrAbaSg" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" formula="mVEWvGqrgE-KcEv8JHNkQw" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="z-FUrvBsRES6qJA0OVoSdA" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" persistable="0" isFixedValue="0" formula="wXMNloy6H02Rg9maIjOjrA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="0XYzHT2FpUCAEdfL9Fh70A" name="EHC continuous fraction" description="Fraction of biliary secreted compound continuously entering the duodenum without being temporarily stored in the gallbladder. The fraction of hepatic bile directly entering the duodenum is species-dependent and amounts to about 30-50% in fasted humans to 100% in rats, because the rat lacks a gallbladder." persistable="0" isFixedValue="0" formula="6IiTT-kz3EKwO8XC9LI1OA" dim="Fraction" quantityType="0" />
-                <Parameter id="Lw4OhvHevE-U27483dC4RQ" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" formula="DvAJ9pUguk6j66nXToeDRA" dim="Density" quantityType="0" />
-                <Parameter id="gGXZBqdRC0WPsOnYzVCVUA" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" formula="6c0RAezHQ0uFe7sGY1NH1w" dim="Dimensionless" quantityType="0" />
-                <Parameter id="wBXW7Cuc_UmzhWHo5AvVmQ" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" formula="5mBkOHiKGUSU53K_TXQjRg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="5SqITGhcl0y9Su4p9x3gAA" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" formula="JSrS3sst4kqTLCPO5bUCJQ" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="lt4M47BL9kWCmqXf1_rJgg" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" formula="tyh0SMaS0EuMnjk90Tp14Q" dim="Nanolength" quantityType="0" />
-                <Parameter id="FgFF58t8JUukLCvoL4yLDw" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" formula="I2-S6h18LU2SsSQArEOtnA" dim="Nanolength" quantityType="0" />
-                <Parameter id="wseqSa3Jck2dDmRZ4zOTyA" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" formula="2zvx2bZP_EayA7on7c4f-w" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="aUl--HjnoU6MnzaSRUX1qw" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" formula="nJBZd22J9UWWkeBQ9WHT4A" dim="HydraulicConductivity" quantityType="0" />
-                <Parameter id="gCBJeNWrH0-pFYq4_DvhaQ" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="xdR0pev0akOEj7NWCPrZKQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="CDfAssTtGEmWOKFnHV58Pg" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="Rh2alOcErkia5Q7gbY5f0A" dim="Dimensionless" quantityType="0" />
-                <Parameter id="FxW9GPVSBE2_rbAsnPXyaA" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" formula="tPjr5rSY9UiroWnuP0SWsg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="K5G3-4dhf0WmpMBM3uX7Kw" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="Va0_TeiZb0yXE_I66eVaaQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="_tX-y-SLGU2yjN9U0M5EfA" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="XL9SLz-2cEeENTo5FcI-Ww" dim="Dimensionless" quantityType="0" />
-                <Parameter id="2SRzQ9Q3qkeMLXM4l_ZLcA" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="WQb3xztHsU6a-l7Ik_j9UA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="D2BcEk4UrUqFtDEAusYVoQ" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="1MY8Xm-DwEaXghDfAqWg4A" dim="Dimensionless" quantityType="0" />
-                <Parameter id="DCtPtBJmYkCV0cURXR3MKw" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="aZEk28VRBEabbqcUeGfXRA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="8mLa5lCqoUCAR1_wkV6RZQ" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="CUXUFgQzNk2HPuYQ9QdYNQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="X8i8Ns3UYU60Jdhfy0_eiQ" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="Anwo8vHuokydjqNmO5_Rww" dim="Dimensionless" quantityType="0" />
-                <Parameter id="ESTC7j6CkUyVDVyBd8-tnA" name="Microsomal protein mass/g tissue" description="Microsomal protein content per gram tissue" persistable="0" isFixedValue="0" formula="Wvakz-fiaEuW1GIXxRbMYA" dim="MassProteinPerTissue" quantityType="0" />
-                <Parameter id="q3D9yBssjkSnFvPgLJcYpw" name="Number of cells/g tissue" description="Number of cells per gram tissue" persistable="0" isFixedValue="0" formula="nFIoVb9lLkuto8jezF_awA" dim="CellQuantityPerTissue" quantityType="0" />
-                <Parameter id="q9Mz3J27EEOp5e7Rhym-tQ" name="Protein mass/g tissue" description="Total protein content per gram tissue" persistable="0" isFixedValue="0" formula="O29U3y0ZREieYPmcSbqiyg" dim="MassProteinPerTissue" quantityType="0" />
-                <Parameter id="o33sKBi4FkWu34meJoU3Hw" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" formula="qWQ4venfWUmIn2t-woN8eg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="jN-dwepNqEW3PwQpC-BLkw" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="5w11sBu-xk-xgJksxDexJQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="hxBRiGYxPU6Fi-4rMrQ4tA" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="Nf0hlIbwjUCVEa6ipFuAcg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="DqHpZTU_pkOEMQjlVqNO7w" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="fFE7clYNwUe-BFN-4v53UQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="TaQUzJGt4UuQOrRKp9kgdg" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="N2EHLcpHrEKlKXuOR9GPUA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="d5x6sh1H_EiOOWnzEoZd6w" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="t7WsokADQEeO2bdWOP4tiA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="jUwRPCgk6EOuZlaK7X8K-w" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="xrf1i8PERk-2TtTkiI22QQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="hqvi8dEKzUqZUeMreMo_HQ" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="Dp_TE6QqBkKHOBN3XXZdUA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="KZq90atnUkOTraq71QAHNA" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="Qnzi3ef5O0eOMGGTcg8ieA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="KZ8SGKP_PUS5Tbj1OSeuRQ" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="DLzCqDA2kU6UxLYAk4A5RQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="ABDyQt6Y90e28mqx89_zmg" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="C7SESItXDkiLqoSyt8Mxcg" dim="Dimensionless" quantityType="0" />
-                <DistributedParameter id="8gXICdMi90SUdtHysiYflA" name="Volume" description="Volume of organ or compartment" persistable="1" isFixedValue="0" formula="fLmmXGJVUE-WnAWMssKd_Q" dim="Volume" quantityType="0" mode="Logical">
-                  <Children>
-                    <Parameter id="C1jDYrdPBUSvS8kEL4ZsQQ" name="Percentile" persistable="0" isFixedValue="0" formula="AgdYQBXL6kGUoiHPkteK9A" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="-2B88wbNR0Wi0mcHEXQoLQ" name="Mean" persistable="0" isFixedValue="0" formula="P1Eknvl73Eq1rvvhEfglNw" dim="Volume" quantityType="0" />
-                    <Parameter id="8cDLD6R5-Um3bUVAQnCI1g" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" formula="LXrfJI8NBEG258aTWBK_wA" dim="Volume" quantityType="0" />
-                  </Children>
-                </DistributedParameter>
-                <DistributedParameter id="OhTAWN3LFUen_YTV87zeng" name="Specific blood flow rate" description="Blood flow rate normalized to the organ volume" persistable="1" isFixedValue="0" formula="EPZXnBPBzESmV0tAzMrneQ" dim="Flow (volume) per organ weight" quantityType="0" mode="Logical">
-                  <Children>
-                    <Parameter id="iLXxgFBv9E2g3_MUBtJeuw" name="Percentile" persistable="0" isFixedValue="0" formula="6cP9KlNekk2pwc1ZMu4p3Q" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="y9ptdd_qb02mbO5mrSgz2g" name="Mean" persistable="0" isFixedValue="0" formula="e2THtU6CAkeJmyVn3lEuXQ" dim="Flow (volume) per organ weight" quantityType="0" />
-                    <Parameter id="thlwr43B10qn7qqyQVVLdQ" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" formula="ww8FjD49H0CZxFR7gXBZOw" dim="Flow (volume) per organ weight" quantityType="0" />
-                  </Children>
-                </DistributedParameter>
-                <Container id="_sbIJKlDHEqfMsTisyn56A" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Plasma" />
-                    <Tag value="Liver" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="nllIRS8UDU620e1YIcxnug" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="owgI66XQcE2ClB4BHV50ew" dim="Volume" quantityType="0" />
-                    <Parameter id="vHvboEGMxUWa2eki80NxxQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="rbp4e7PXpUyuD1ZtA8Ocxw" dim="Volume" quantityType="0" />
-                    <MoleculeAmount id="3EA1OLywM0SY7jEyMKI0Hw" name="Drug" icon="Drug" persistable="0" isFixedValue="0" formula="Xllg9rhJIU6txsX01-PF3Q" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="KY7dGflw8k6EIsdoAbqcRQ" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Parameter id="211vROR3bUaL-xS-NhEYXQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="IIe78s2aZk6bFYccSMdHyg" dim="Dimensionless" quantityType="0" />
-                        <Observer id="mnEx4L0QoUupyGijInfQKw" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Drug, Observer" />
-                      </Children>
-                    </MoleculeAmount>
-                    <MoleculeAmount id="hrr55lBGpk-JELJnYJmJzg" name="Cyp" icon="Enzyme" persistable="0" isFixedValue="0" formula="wb5yCXJZxUeVY_7iSBmoSg" dim="Amount" quantityType="Enzyme" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="uzoF88DNgkSHJZg8mEme5A" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" formula="iwcSrEqy106AOpDooy3T8A" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="yuFZVHiARUO8oukyCVimkw" name="Relative expression out." description="Relative Expression that will be used in the simulation" persistable="0" isFixedValue="0" formula="GtBZCb_uvUKgURPKDkyZKA" dim="Fraction" quantityType="0" />
-                        <Parameter id="t-nNrASqAkGS90ST2Vx6bg" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" persistable="0" isFixedValue="0" formula="Qv2OyMi-nU-kPqJ48WVuVw" dim="Fraction" quantityType="0" />
-                        <Parameter id="ewfTSPKj8Uua54PiHbjm1w" name="Relative expression" description="Relative expression" persistable="0" isFixedValue="0" formula="iUzjEbj_NkSh4u8TNBhFgQ" dim="Fraction" quantityType="0" />
-                        <Parameter id="JYIb7ISo7kuQZ9jByiCUzw" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Observer id="v3gHhVwjXUK-IZpWdu5EHg" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Enzyme, Observer" />
-                      </Children>
-                    </MoleculeAmount>
-                    <MoleculeAmount id="Ekd8MLRsmUascjYqYKSMEQ" name="Drug-Cyp Metabolite" persistable="0" isFixedValue="0" formula="c5BRgaRFWESO5LrB7MgYrg" dim="Amount" quantityType="Metabolite" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="pOpDW054BUyToUuxAMTSeg" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Observer id="FgvyUhNS1UWrNt0dw-MTfw" name="Fraction of dose" description="Metabolized fraction of administered dose" persistable="1" isFixedValue="0" formula="aUoTQ3n3a0OShljd8bUj3w" dim="Fraction" quantityType="Metabolite, Observer" />
-                      </Children>
-                    </MoleculeAmount>
-                    <Reaction id="S3GEQXh3v0e_ua7bLgJ7BQ" name="Cyp-ME" icon="Metabolism" mode="Logical" containerType="Other" dimension="Dimensionless" formula="NrKgrsKmwkiGET1q7OIPYg">
-                      <Educts>
-                        <ReactionPartner stoichiometricCoefficient="1" partner="3EA1OLywM0SY7jEyMKI0Hw" />
-                      </Educts>
-                      <Products>
-                        <ReactionPartner stoichiometricCoefficient="1" partner="Ekd8MLRsmUascjYqYKSMEQ" />
-                      </Products>
-                      <ModifierNames>
-                        <ModifierNamesChild>Cyp</ModifierNamesChild>
-                      </ModifierNames>
-                    </Reaction>
-                  </Children>
-                </Container>
-                <Container id="d9wdan-6bEKXeRNfnCMK0g" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="BloodCells" />
-                    <Tag value="Liver" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="GzqEPS1PhEaNmTQunAMnPg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="owgI66XQcE2ClB4BHV50ew" dim="Volume" quantityType="0" />
-                    <Parameter id="UdCWW_cwx0WZ3q7g6O-xTg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="tFZiRJ-Sv0qf0gsV7ycmYw" dim="Volume" quantityType="0" />
-                    <MoleculeAmount id="Ka94IY55pkyxs6zgBn7D9g" name="Drug" icon="Drug" persistable="0" isFixedValue="0" formula="jFSKrzsMQEeziZVfMQjRcg" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="VfJWh1xkD06aaDJgVvNpgQ" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Parameter id="kUA3QTAmXUKDKnh2ZoRYlw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="eSpfQG0j8UWYSo-2NW04XQ" dim="Dimensionless" quantityType="0" />
-                        <Observer id="Gd6IBASnkUyu7bxL-relfg" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Drug, Observer" />
-                      </Children>
-                    </MoleculeAmount>
-                    <MoleculeAmount id="8fgO_L3QKUWGKCqM-rYUBA" name="Cyp" icon="Enzyme" persistable="0" isFixedValue="0" formula="wb5yCXJZxUeVY_7iSBmoSg" dim="Amount" quantityType="Enzyme" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="cTZ_P9rgtEaljFtlF-RV0Q" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" formula="HvmgMQsLukq5RGSHCnPSzA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="fMuDXcqSFU6pWkQ_H_V_bQ" name="Relative expression out." description="Relative Expression that will be used in the simulation" persistable="0" isFixedValue="0" formula="GtBZCb_uvUKgURPKDkyZKA" dim="Fraction" quantityType="0" />
-                        <Parameter id="KfSI1NJ4PEirhekBIzbtJw" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" persistable="0" isFixedValue="0" formula="FTxLv_b4CkKigLwWdcA4xg" dim="Fraction" quantityType="0" />
-                        <Parameter id="UFGv6u6r-0S5tsQyMeRkEQ" name="Relative expression" description="Relative expression" persistable="0" isFixedValue="0" formula="_J3C13ewoUatoCS2w-zxeg" dim="Fraction" quantityType="0" />
-                        <Parameter id="yUxKbojYPEKG_r58iYYbsQ" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Observer id="nlRN3uB2m0qNjZ9FXre3lQ" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Enzyme, Observer" />
-                      </Children>
-                    </MoleculeAmount>
-                    <MoleculeAmount id="ghZlYVc8bUWds8IVlHfMNA" name="Drug-Cyp Metabolite" persistable="0" isFixedValue="0" formula="WgsOAosYKkSS8a7PGTPIjQ" dim="Amount" quantityType="Metabolite" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="8yxdpnTurEGTx5QVhpGxmA" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Observer id="KWmZzGrCMkKOwB4hbaBQCg" name="Fraction of dose" description="Metabolized fraction of administered dose" persistable="1" isFixedValue="0" formula="aUoTQ3n3a0OShljd8bUj3w" dim="Fraction" quantityType="Metabolite, Observer" />
-                      </Children>
-                    </MoleculeAmount>
-                    <Reaction id="ES1xC2aipUCRCxkp0mjHJg" name="Cyp-ME" icon="Metabolism" mode="Logical" containerType="Other" dimension="Dimensionless" formula="NrKgrsKmwkiGET1q7OIPYg">
-                      <Educts>
-                        <ReactionPartner stoichiometricCoefficient="1" partner="Ka94IY55pkyxs6zgBn7D9g" />
-                      </Educts>
-                      <Products>
-                        <ReactionPartner stoichiometricCoefficient="1" partner="ghZlYVc8bUWds8IVlHfMNA" />
-                      </Products>
-                      <ModifierNames>
-                        <ModifierNamesChild>Cyp</ModifierNamesChild>
-                      </ModifierNames>
-                    </Reaction>
-                  </Children>
-                </Container>
-                <Container id="44VqNxVA40SVe6agWBprfg" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Interstitial" />
-                    <Tag value="Liver" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="0Nl4BqVa-kiX05mlfZGnSw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="owgI66XQcE2ClB4BHV50ew" dim="Volume" quantityType="0" />
-                    <Parameter id="GyEE2YJLLkerdNEp9JPNZg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="4VSppd3W3E6-12kllCJ0Mg" dim="Volume" quantityType="0" />
-                    <Parameter id="2UFXblDCB06S7fEtBd68NQ" name="pH" description="pH" persistable="0" isFixedValue="0" formula="tKjHIxsi60KoHEPhXQBZrw" dim="Dimensionless" quantityType="0" />
-                    <MoleculeAmount id="OS3dPN2ioUidstWIZgpXQA" name="Drug" icon="Drug" persistable="0" isFixedValue="0" formula="5f74_NGKfEyjYpCyj_1XNw" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1">
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-                        <Parameter id="k1xi2FFc8UK5AngqUq5SwQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="R-bZvE99jU20popHwvrhyg" dim="Dimensionless" quantityType="0" />
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-                  <Tags>
-                    <Tag value="Intracellular" />
-                    <Tag value="Liver" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="TFVZ2Lebl0arayqzF9l5kw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="M9arQg_qfEGMA7JdlSXkFA" dim="Volume" quantityType="0" />
-                    <Parameter id="7uutlVTLiEyyvA0xTZYE7A" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="3l84whkuX0S7xUUHglUQpg" dim="Volume" quantityType="0" />
-                    <Parameter id="JQeJICDlnU6VAma78GsakQ" name="pH" description="pH" persistable="0" isFixedValue="0" formula="cEWpv7qH4U28c-iVHM5xyQ" dim="Dimensionless" quantityType="0" />
-                    <MoleculeAmount id="danwiYvRrEOmB-ioVuNjmA" name="Drug" icon="Drug" persistable="0" isFixedValue="0" formula="B-kqQ6VrgkCEZq3syCKkhg" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1">
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-                        <Parameter id="4SmjNVB5XU-Uj4wdjQx8bQ" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Parameter id="PZyr-REL2E63FEJ1HbonRg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="6hUqG0DY40KRqG5wT8p0VQ" dim="Dimensionless" quantityType="0" />
-                        <Observer id="AXPBYDmuv0-o726X7VIIbw" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Drug, Observer" />
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-                    <MoleculeAmount id="i5XGFUy0Dk2cAj448EmfxQ" name="Cyp" icon="Enzyme" persistable="0" isFixedValue="0" formula="wb5yCXJZxUeVY_7iSBmoSg" dim="Amount" quantityType="Enzyme" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="sKPj4toClkGGwOZ_-Fj99w" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" formula="EBTdTAhM6kepQqxdk42j1g" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="Nf5rnqCfd0Oib9fYpegg0g" name="Relative expression out." description="Relative Expression that will be used in the simulation" persistable="0" isFixedValue="0" formula="GtBZCb_uvUKgURPKDkyZKA" dim="Fraction" quantityType="0" />
-                        <Parameter id="nNbqW70mN0-V7GkmFl-SnQ" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" persistable="0" isFixedValue="0" formula="JqYT-cyNME23vnKE_aH8Rg" dim="Fraction" quantityType="0" />
-                        <Parameter id="Zm2D6n6veUmsBw6tS8RdZg" name="Relative expression" description="Relative expression" persistable="0" isFixedValue="0" formula="3uULMHPmrke-86E26nHfhA" dim="Fraction" quantityType="0" />
-                        <Parameter id="9m5_sJsQOE-q2AO_guEWbw" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Observer id="0nc8azF4Vkmm4s4jmhJ2Yw" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Enzyme, Observer" />
-                      </Children>
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-                    <MoleculeAmount id="yszSuFu_uE2LLPaSGTRBsA" name="Drug-Cyp Metabolite" persistable="0" isFixedValue="0" formula="i-PUmydVoUeG04ZzdjRvxA" dim="Amount" quantityType="Metabolite" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="u7qiP4WnmkeZXLgp40n6DA" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Observer id="JUgAhkPIGkGiU-8x2X98KA" name="Fraction of dose" description="Metabolized fraction of administered dose" persistable="1" isFixedValue="0" formula="aUoTQ3n3a0OShljd8bUj3w" dim="Fraction" quantityType="Metabolite, Observer" />
-                      </Children>
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-                    <Reaction id="E5LeuF7cEEeib7B3yxM9VA" name="Cyp-ME" icon="Metabolism" mode="Logical" containerType="Other" dimension="Dimensionless" formula="NrKgrsKmwkiGET1q7OIPYg">
-                      <Educts>
-                        <ReactionPartner stoichiometricCoefficient="1" partner="danwiYvRrEOmB-ioVuNjmA" />
-                      </Educts>
-                      <Products>
-                        <ReactionPartner stoichiometricCoefficient="1" partner="yszSuFu_uE2LLPaSGTRBsA" />
-                      </Products>
-                      <ModifierNames>
-                        <ModifierNamesChild>Cyp</ModifierNamesChild>
-                      </ModifierNames>
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-                  </Children>
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-                <Container id="ARVSe4y_M0aeOMjdh6U3Aw" name="Drug" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Observer id="1n2_AQMS30CS7w6QXEWa3w" name="Interstitial Unbound" description="Interstitial Unbound" persistable="1" isFixedValue="0" formula="sb2EI4hIhEWxy5ZYMY2QFw" dim="MolarConcentration" quantityType="Drug, Observer" />
-                    <Observer id="13tdoFLDDUKwH6R_CtXyog" name="Intracellular Unbound" description="Intracellular Unbound" persistable="1" isFixedValue="0" formula="F5kFVlFTnEmJToE6fKssfA" dim="MolarConcentration" quantityType="Drug, Observer" />
-                    <Observer id="UGQTRiLUg0CAtgmcT2JEQw" name="Tissue" description="Tissue" persistable="1" isFixedValue="0" formula="wztK_G9P_0mMbsEE9LSVMw" dim="MolarConcentration" quantityType="Drug, Observer" />
-                  </Children>
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-              </Children>
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-            <Container id="jKZN7gsm20S2tR43iFgyDg" name="Lung" description="Lung" icon="Lung" mode="Logical" containerType="Organ">
-              <Tags>
-                <Tag value="Lung" />
-                <Tag value="TissueOrgan" />
-              </Tags>
-              <Children>
-                <Parameter id="Ve5CJbft2EeLbGQ6ckJ8Ag" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" formula="7dPLwFOO9UGq8vruSpVNOA" dim="Volume" quantityType="0" />
-                <Parameter id="57tUq8omSE-WKr5W0ddiIg" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" formula="FbGzbaLst0K5o2gc_gSjaQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="XHomb6GtxEqVvbjHeuBlnw" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" formula="KF3BvcZj1EmUBDYoVaeQeQ" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="_i-l-VGqPEWDXJLXe58m3A" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" persistable="0" isFixedValue="0" formula="y6o57Z-r80m-oR0Pb6uzOA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="35Y_3vF_JUejEH-2kTmx3w" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" formula="EBB0vo3K3kKp7513k25eoA" dim="Density" quantityType="0" />
-                <Parameter id="3rRPagubBUCEM1ztwfYs7g" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" formula="PrkHtHnNoUCbSltnztn4jw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="C2OxoDLHukGnt0aAwXPimQ" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" formula="2QqtCG62bkaO_PLyItvQdw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="KZcZbFzNwkuKWV4JmmCUXw" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" formula="9CGUlnf78UWlwNY9rxiE6Q" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="IKPPEJh_R0azIPTFWARHxA" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" formula="QmFtISz_8kyRC_1ImFcBpQ" dim="HydraulicConductivity" quantityType="0" />
-                <Parameter id="IgkaPjeJ-E-h2I1UJeCY9A" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" formula="-Q4BLoMK60arlBl5e32eMA" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="339aIPGI9Eq2jBfH4hS3vQ" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" formula="vWoHqcUJA0CcPrPeP6_44w" dim="Nanolength" quantityType="0" />
-                <Parameter id="wex9xG5acUK1RjclB7Cv0g" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" formula="8FyG_xjHKE-5fgA2pXwSfg" dim="Nanolength" quantityType="0" />
-                <Parameter id="9OeOThDY-E2ByHSZOnKPnQ" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="slXC9W5U90234K0EScIANA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="aUGlSQfpDU-DmpXous4Kvw" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="RNvmIzdrF0qFJY8QuTG0AQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="g65w4jvVV02_9si3xHkZFA" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="RbNPojZh4U-XkpNW6xvHag" dim="Dimensionless" quantityType="0" />
-                <Parameter id="k7QEOA1w702byMz1TW4e3g" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="qMdS2XxcZE-LDlqIfgJzfA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="9icA_mNraUunRUHHx30K6Q" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="6iVyaKJ8LUOIOq9QzExUNg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="_2Y8u6jwcECHs9gxlAka8w" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="ri5bD0vlAEmfzzsF_vBuYA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="IV5EURl7bE658ZwPpJR9DQ" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="dAzdqGgjl0OYFqSp6Fdx1Q" dim="Dimensionless" quantityType="0" />
-                <Parameter id="lR6ZnS4mxECYTZ4LK4RAnw" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="NdpeIhuggUCd-A1U_uRGbw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="DBDRYnzye0mv24hUGhuxpw" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="NohRqwWL90mFaxuIDd43SA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="N8R4scJaC02jj8FCuKSrtw" name="Protein mass/g tissue" description="Total protein content per gram tissue" persistable="0" isFixedValue="0" formula="sl48Foyl7k-8dmbTcNNqHQ" dim="MassProteinPerTissue" quantityType="0" />
-                <Parameter id="7p6zI0263EClHqNeqPbi5A" name="Number of cells/g tissue" description="Number of cells per gram tissue" persistable="0" isFixedValue="0" formula="5PpOHEwnD0OADeYn6VUpsw" dim="CellQuantityPerTissue" quantityType="0" />
-                <Parameter id="pYJ-INtRq0CnAHscnXNK3g" name="Microsomal protein mass/g tissue" description="Microsomal protein content per gram tissue" persistable="0" isFixedValue="0" formula="nXVJyUBzm0eJUmHDIAfMFA" dim="MassProteinPerTissue" quantityType="0" />
-                <Parameter id="9s2tTPLxlUOWS3iGJVFYdA" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" formula="K1FWUrpN1kaBMxWV7m2dGA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="O0AJuR5j7E2VHSKUwgRxwg" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="4H4oDsnnS0i2DpsdgWZnbw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="SqGgxlz45U-WqSD6_YfT3w" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="3EJ4h0pQJEWVrKm1EXdWpw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="dOzKsD6dUk6Qkz4DbyM4VA" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="5kM0RYmOb0WoNB61xzj9cA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="scr_gU_R40GGVZnDS857iw" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="eQOkCUHCjEiudm3ejKUPtA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="pk9ZtvxHCECvhc3I0qEx6Q" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="GrawtMxIMk-AB-VucHgn8A" dim="Dimensionless" quantityType="0" />
-                <Parameter id="9QQEW5I4tkS0wpAP-GHhlQ" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="YH_OhEiiqEW0hU-e99R-NQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="3itsXeLrd06WLEri6Z85kw" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="7dkWXb5Q6EqgV8wF87OtVw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="YoVAy5u5jE2Zi5Ob_veDcg" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="8Iq9MRE850eadlCPdD0yjQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="rPG-tFJbfUqX2VkaYsAQnw" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="LRr_NH_Qpk68-fLPj_SQPg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="qhaOHCk06Ea3IrkMhUvTww" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="eRLgguLrSEuIyIlD9HHhHA" dim="Dimensionless" quantityType="0" />
-                <DistributedParameter id="hJNEEChA5Emfx2QVDDqjng" name="Volume" description="Volume of organ or compartment" persistable="1" isFixedValue="0" formula="uNOcnTRjT0-k0PJ5bqgNtg" dim="Volume" quantityType="0" mode="Logical">
-                  <Children>
-                    <Parameter id="oMc0J7uVE0G3XUNQO9mclg" name="Percentile" persistable="0" isFixedValue="0" formula="tNMVO7ZyYkCvkkTaTVk0Fg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="x2fj14G8MU-yq6zmlGKKHg" name="Mean" persistable="0" isFixedValue="0" formula="0vc9MYkAzEKgXZf251kSWQ" dim="Volume" quantityType="0" />
-                    <Parameter id="CUab_ASo0UaozlHA27Ra9w" name="GeometricDeviation" description="Geometric standard deviation of LogNormal distribution" persistable="0" isFixedValue="0" formula="fD_ZTJliWEmO6YN2dAL2Ig" dim="Dimensionless" quantityType="0" />
-                  </Children>
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-                <DistributedParameter id="IQsBMiJ8b0qPRnodEoTV3g" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="1" isFixedValue="0" formula="Jae61NqLR065UA1CPljcRg" dim="Dimensionless" quantityType="0" mode="Logical">
-                  <Children>
-                    <Parameter id="cg1tHgdv5ECFTZXYrW15zQ" name="Percentile" persistable="0" isFixedValue="0" formula="j1sP_aKWiky212hT95yRjA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="6G7ITTSK2kmxZLMaxlw_Jw" name="Mean" persistable="0" isFixedValue="0" formula="VajiaLJzPUO834xgd3fUog" dim="Dimensionless" quantityType="0" />
-                  </Children>
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-                <Container id="y37Pbm_v8kq2DDBtieuQ_w" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Plasma" />
-                    <Tag value="Lung" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="1QgHev9KdEyvtquL3xFbow" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="owgI66XQcE2ClB4BHV50ew" dim="Volume" quantityType="0" />
-                    <Parameter id="iqfZmMbUW0KV0E3Gw-HsRw" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="rbp4e7PXpUyuD1ZtA8Ocxw" dim="Volume" quantityType="0" />
-                    <MoleculeAmount id="w1ZFXYWXKkaN0StkX-XcEg" name="Drug" icon="Drug" persistable="0" isFixedValue="0" formula="Yb7Z35B0tE-GRX1rUWsrGQ" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="Od3AkPGfO062QlJZB47ohg" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Parameter id="1NsiMV_32EitaNLe6RzkSA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="z15fByUUOUibuybre0akdA" dim="Dimensionless" quantityType="0" />
-                        <Observer id="c8O6HD97kkmJSrgaJhivuA" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Drug, Observer" />
-                      </Children>
-                    </MoleculeAmount>
-                    <MoleculeAmount id="DeRTrWQY9U-9QF-SWFLm_g" name="Cyp" icon="Enzyme" persistable="0" isFixedValue="0" formula="wb5yCXJZxUeVY_7iSBmoSg" dim="Amount" quantityType="Enzyme" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="Pt5f90zm5kmZ-z6R4zBdqg" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" formula="e4iInlg4JECLIC9-meTC1w" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="Z2lQ2rYLoEqayv4cCevwwg" name="Relative expression out." description="Relative Expression that will be used in the simulation" persistable="0" isFixedValue="0" formula="GtBZCb_uvUKgURPKDkyZKA" dim="Fraction" quantityType="0" />
-                        <Parameter id="zF5pvkZRpEW0LEEw3Q10eQ" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" persistable="0" isFixedValue="0" formula="Qv2OyMi-nU-kPqJ48WVuVw" dim="Fraction" quantityType="0" />
-                        <Parameter id="PIJSp48LV0murUU-octNXw" name="Relative expression" description="Relative expression" persistable="0" isFixedValue="0" formula="iUzjEbj_NkSh4u8TNBhFgQ" dim="Fraction" quantityType="0" />
-                        <Parameter id="6w2ftMMvR0qheFpFdbW-5w" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Observer id="Dl810qeMa0yYL8v5rXf11A" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Enzyme, Observer" />
-                      </Children>
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-              <Tags>
-                <Tag value="Muscle" />
-                <Tag value="TissueOrgan" />
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-                <Parameter id="0wldP6fpuk-oy555GzJLuA" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" formula="4ISmJWQtpk2AF_LrYQJo2Q" dim="Volume" quantityType="0" />
-                <Parameter id="RoqjeikItkCLfrcxCOFSyA" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" formula="FbGzbaLst0K5o2gc_gSjaQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="qYRo0J9nu0yCJzed5ESlgA" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" formula="mVEWvGqrgE-KcEv8JHNkQw" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="OPqKVQHTqUGKzfIWCGnwRQ" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" persistable="0" isFixedValue="0" formula="-ZWe5iS9O06XEn1hb0IUng" dim="Dimensionless" quantityType="0" />
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-                <Parameter id="pY6k1pSOj0i2Qm0I8qnk9A" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" formula="5RYK04Ica0mWWfq137AAPg" dim="Density" quantityType="0" />
-                <Parameter id="1Pgu4HKBlEibhX4Kefe89g" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" formula="10LNQfjsn0i3kmY5ldi9lw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="2wLg902lS06eUI2SbXcgsw" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" formula="-EW2kgo5tEa3-8Xae_wuyg" dim="Nanolength" quantityType="0" />
-                <Parameter id="_nUvilHsDEeYxhTW7vUNag" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" formula="QEl6YR5Irk2HJdwFJqCd5w" dim="Dimensionless" quantityType="0" />
-                <Parameter id="dvKOVnp6PEWXS9y03DaYIQ" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" formula="CxtSypVVEUOKRLrBM4uk5A" dim="Flow (volume)" quantityType="0" />
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-                <Parameter id="I-9CEtqQ80upvsjnmwtgSA" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" formula="yLfNdG3hWUedA320TLKMIw" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="eAdq8CZQT0GLNNisqH2r3g" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="AiowTOyltESoKioH1_s81Q" dim="Dimensionless" quantityType="0" />
-                <Parameter id="2xvo-F5evkukaXJmjRFdCA" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="vR76j7DHxkyvUp82YXEzew" dim="Dimensionless" quantityType="0" />
-                <Parameter id="YXJ2vIta4Uubi3HSq7UO-g" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" formula="F_Mz_BLFsUaYvj8e4roWIA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="Igryd-RaqEqdwXiRn9cZ5w" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="BSHQIBSb7EOnMEsbZsQp6A" dim="Dimensionless" quantityType="0" />
-                <Parameter id="qOPxNXiG3k-lZn74Emuilw" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="clyfFUGHAUiqOowsoUHOJQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="Tg5nCbtarU-5D9CLS4oWBA" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="dvR-odUuZECWHYkqfena9w" dim="Dimensionless" quantityType="0" />
-                <Parameter id="5fiuFsznO0qepkkYHT-djA" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="5RW7e_-FmkGJe2NBtntbJA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="C0anutKx10mCWlj8LK2AMw" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="wcabgaIV30yTQ1GJ0RViOQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="EO1ExhaStEu4aafEWTgtew" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="B9s0zxrpQkOrZPPsjlN17g" dim="Dimensionless" quantityType="0" />
-                <Parameter id="KRD3FSFLjEKmNOnD5nz-KQ" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="o1vuLQpc80yG2szjmfrj5w" dim="Dimensionless" quantityType="0" />
-                <Parameter id="6CAXZJZbWkeQHlUG6gxDAg" name="Microsomal protein mass/g tissue" description="Microsomal protein content per gram tissue" persistable="0" isFixedValue="0" formula="kqEGoAzVq0WlOasVf0hvkg" dim="MassProteinPerTissue" quantityType="0" />
-                <Parameter id="wb9q7zgXVUyxgQAw2sR0qA" name="Number of cells/g tissue" description="Number of cells per gram tissue" persistable="0" isFixedValue="0" formula="KsEOoBChE0StAdXLTJbvGQ" dim="CellQuantityPerTissue" quantityType="0" />
-                <Parameter id="4dBszJjAiE64RATObAhYQw" name="Protein mass/g tissue" description="Total protein content per gram tissue" persistable="0" isFixedValue="0" formula="z9XBYnfyvUyl9N020Z6m2g" dim="MassProteinPerTissue" quantityType="0" />
-                <Parameter id="j0fltjbVgky3bFojqY3K-g" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="r2Xiyt17mU2TKh2lVQV-VA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="AaBaX7zn5kaCPVGjYNt-pA" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="DRM-bOmVrUWLyO7r8Dnpeg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="la_JUky-QUa-mN19JSB0Sg" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="SMCdOI8E30ODblI_a3qFkg" dim="Dimensionless" quantityType="0" />
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-                <Parameter id="zNnej-lGdkWVmnZ-wS5K2g" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="kFcrT33lJ0-P99ST2qQE2A" dim="Dimensionless" quantityType="0" />
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-                <Parameter id="BomC9FNZ70-jjVxGCJBrFw" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="Dq9SrRtcwEqxe0rAC4NswA" dim="Dimensionless" quantityType="0" />
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-                        <Parameter id="vUae-sx2xkOIHAOVL1-stg" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Observer id="lHf8W-JiJkCdZ-IrXQoGhw" name="Fraction of dose" description="Metabolized fraction of administered dose" persistable="1" isFixedValue="0" formula="aUoTQ3n3a0OShljd8bUj3w" dim="Fraction" quantityType="Metabolite, Observer" />
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-                    <Reaction id="pp9ami0R0EGNQTVNjN4uGw" name="Cyp-ME" icon="Metabolism" mode="Logical" containerType="Other" dimension="Dimensionless" formula="NrKgrsKmwkiGET1q7OIPYg">
-                      <Educts>
-                        <ReactionPartner stoichiometricCoefficient="1" partner="4sHoPdMFYUKpIuxmRIUXMQ" />
-                      </Educts>
-                      <Products>
-                        <ReactionPartner stoichiometricCoefficient="1" partner="z0jNSkB4KUuzkmgmvlOfOg" />
-                      </Products>
-                      <ModifierNames>
-                        <ModifierNamesChild>Cyp</ModifierNamesChild>
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-                </Container>
-                <Container id="YaxUUdkndEa-mOri1WPf0g" name="Drug" mode="Logical" containerType="Molecule">
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-                    <Observer id="2Lqvp1pf906UyyAkMRYdxw" name="Interstitial Unbound" description="Interstitial Unbound" persistable="1" isFixedValue="0" formula="sb2EI4hIhEWxy5ZYMY2QFw" dim="MolarConcentration" quantityType="Drug, Observer" />
-                    <Observer id="0IIhlcyRpUyyiiXJ3nN7eg" name="Intracellular Unbound" description="Intracellular Unbound" persistable="1" isFixedValue="0" formula="F5kFVlFTnEmJToE6fKssfA" dim="MolarConcentration" quantityType="Drug, Observer" />
-                    <Observer id="Ugr9a0BXUkmw5qDJVN4jgA" name="Tissue" description="Tissue" persistable="1" isFixedValue="0" formula="wztK_G9P_0mMbsEE9LSVMw" dim="MolarConcentration" quantityType="Drug, Observer" />
-                  </Children>
-                </Container>
-              </Children>
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-              <Tags>
-                <Tag value="Pancreas" />
-                <Tag value="Portal Vein Supplying Organ" />
-                <Tag value="TissueOrgan" />
-              </Tags>
-              <Children>
-                <Parameter id="p9wpLefnbU-wj7H-isBVuQ" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" formula="dgIJ-oFkQEuf25e79u_6EQ" dim="Volume" quantityType="0" />
-                <Parameter id="zeFbp0_ufUixKy95psHcqA" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" formula="FbGzbaLst0K5o2gc_gSjaQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="w3_XeSuxIE-iCb9vhsu0dQ" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" formula="mVEWvGqrgE-KcEv8JHNkQw" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="63Th2xsgOEOpaoSeAIlbGA" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" persistable="0" isFixedValue="0" formula="z0YW2pBkjkO4iBDeyElq3g" dim="Dimensionless" quantityType="0" />
-                <Parameter id="d71zzYCZEkOXAJU8Kanc5A" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" formula="xXDjDKmb9U26X6EXLc5aeA" dim="Density" quantityType="0" />
-                <Parameter id="PSQU4uPAiU2Z5-kIkP1CMA" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" formula="9f4SrT0GUkybdAL5qCvCbQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="VZty7AGzJ0eT0Eyrykye4A" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" formula="o_NGsrlWrUSa6nIm3DE9eQ" dim="HydraulicConductivity" quantityType="0" />
-                <Parameter id="80tt5RB1GkC07BNNKbjqow" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" formula="XslqFggPHEKPgiy9slZG3g" dim="Nanolength" quantityType="0" />
-                <Parameter id="VbNYndSUF0eEv9AmRXfM_w" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" formula="wJ8p6Ku_WEijVHkcRftAJQ" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="I-TLTYa9wEO6RDogzKy27A" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" formula="XmV-myoZ7k6FZVuatzVSPw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="8OhSvL-8QE-bp5xRqjWnpQ" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" formula="jfsUtjZ_6E2lUA2pnWWnSw" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="mv8IFIR7FESgZzgpc9N0nQ" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" formula="5HWR4eglfEixJljs1b5ySQ" dim="Nanolength" quantityType="0" />
-                <Parameter id="1RmLd-JYs0aTZ5gEF59Pjg" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="xiOJ6zbMTEOUp-Q3OyQvlg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="LMRdFBU14UGpHOXNpJBuSw" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="XhCkHGStgE-xlVjII2sogg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="lNkslt0wNU6LMEz0ddkHWw" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" formula="zr7EM3WCJk-xoquspvyC4w" dim="Dimensionless" quantityType="0" />
-                <Parameter id="QZ0uolxXS0OJ5HK1q8kFNw" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="HXjNJaxV0E21cP1w4-8g8g" dim="Dimensionless" quantityType="0" />
-                <Parameter id="Wmg77nBLH0ugJd7aSXrOCg" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="WW9vSieUKUGId9RT5NIz-w" dim="Dimensionless" quantityType="0" />
-                <Parameter id="waCGm-kogECNQ7hpuy8gjA" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="1n7O4qAVdkqKLWEzss6DYA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="QKOfD8aZjEqtM4phcICQfg" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="_SemMiRuFUSBJ6HJ6B1KLA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="lNDBnEqB9k6p65bKm7N0ag" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="jLNaX7L4kESSpfNOV6Q6XQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="uyKYe5o-g0iLYV4eV-d9QQ" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="NBd_nEBjl0eykoj4UbjeMQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="VDbr7LYfYUGoTg8TqGyhAQ" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="bVyXrwVNmkmTm6hmxhbUzg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="tb5pUdJyyEOmyZ7tvceT1g" name="Protein mass/g tissue" description="Total protein content per gram tissue" persistable="0" isFixedValue="0" formula="yGIqvDO5BEKDDvDl-IufCA" dim="MassProteinPerTissue" quantityType="0" />
-                <Parameter id="X-9ffvxhh0uI4lB7UeKNGA" name="Number of cells/g tissue" description="Number of cells per gram tissue" persistable="0" isFixedValue="0" formula="Kf9_xuDbYEOiyYzNTRj0jQ" dim="CellQuantityPerTissue" quantityType="0" />
-                <Parameter id="OV9vF12us0KFoJsMSzmRXQ" name="Microsomal protein mass/g tissue" description="Microsomal protein content per gram tissue" persistable="0" isFixedValue="0" formula="XuxBcsdyt0uAjceVFu0HDw" dim="MassProteinPerTissue" quantityType="0" />
-                <Parameter id="1ooKYZ4n80-L1lp-kVYAzQ" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" formula="r_rvBzyYm0el8wvxSzbF-g" dim="Dimensionless" quantityType="0" />
-                <Parameter id="oklAka_qnUqAiZwDdQxJtw" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="NEJ3vwe8GkO2dx1BhO7sCw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="lwXVd7eRkUumZ4EEvJ23Sg" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="8CF_B5XXI0anrqNVw_vMpg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="tN1pLOnEWUukfOY4sI8QiQ" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="dLaVwVee5UqH7Bllrk-axg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="iKsVzzmW20OyKnMnsuKeog" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="fZFVjqbMjU2TEJp8jRz9DA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="h2fAKH_6l0WjQA8bW-hnxg" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="sEIb-6fMIUqHqfyTQMfjyA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="5eFM5fwOAkKdjsi0N3sptw" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="tbaXnu5Z2EyfqXleqxWPvQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="zvqFesB6hECEAWx5qcvfRA" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="JPWOxOg2oESCGWXPjO4mgg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="U3QGYlg1Tkmiuoq1_z7TeQ" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="rDaFqpkP9UWdJAWHEqUc9Q" dim="Dimensionless" quantityType="0" />
-                <Parameter id="cDjO00Ncb02Z5srynERwJg" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="pI1tuljWGEm7WL2zYnweoQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="ZHDxFCkfy0uPAyWbnxyCzA" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="_bnDO24amkGkda03YHEKZw" dim="Dimensionless" quantityType="0" />
-                <DistributedParameter id="zWYYOp3btE-3-Yr1gAJhOg" name="Volume" description="Volume of organ or compartment" persistable="1" isFixedValue="0" formula="dRPNp9bxfkW36CVljIIwjQ" dim="Volume" quantityType="0" mode="Logical">
-                  <Children>
-                    <Parameter id="hLA5NaucuUOqFQ97hX3YoA" name="Percentile" persistable="0" isFixedValue="0" formula="RBNL6RhL_ky7buwqKXT0bQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="H5g_v6vM-0OqLvb4Bv-gzw" name="Mean" persistable="0" isFixedValue="0" formula="8BQwsgepxkenDfzinM-Q0w" dim="Volume" quantityType="0" />
-                    <Parameter id="-nBHWa9CYEeMeg5QEGGz2Q" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" formula="iY_M8DaMv0KiQ4wZJb5nSA" dim="Volume" quantityType="0" />
-                  </Children>
-                </DistributedParameter>
-                <DistributedParameter id="55mVICxSsEyOBEaPtAPy2g" name="Specific blood flow rate" description="Blood flow rate normalized to the organ volume" persistable="1" isFixedValue="0" formula="YSl4lSJd60OWmW9DApyHyQ" dim="Flow (volume) per organ weight" quantityType="0" mode="Logical">
-                  <Children>
-                    <Parameter id="PXyhNDAEsESbDwl-j3zBOg" name="Percentile" persistable="0" isFixedValue="0" formula="GPwbJ1ns6Eap9Bh8300QxQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="hqS0wbQUpkyikIf29abg3w" name="Mean" persistable="0" isFixedValue="0" formula="kGC6wAj7Vk6o93C_dtwqiA" dim="Flow (volume) per organ weight" quantityType="0" />
-                    <Parameter id="oNm8I84jrUaP7NdlV-PUdg" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" formula="B03em_nchUWcUfUKickWZQ" dim="Flow (volume) per organ weight" quantityType="0" />
-                  </Children>
-                </DistributedParameter>
-                <Container id="PPDj7eTW0EWOYgdN7qEVYQ" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Plasma" />
-                    <Tag value="Pancreas" />
-                    <Tag value="Portal Vein Supplying Organ" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="UVm9Rn9ra0ud3PhUsNpQcw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="owgI66XQcE2ClB4BHV50ew" dim="Volume" quantityType="0" />
-                    <Parameter id="GCl5ukAa1Ui4DOkREQzLBA" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="rbp4e7PXpUyuD1ZtA8Ocxw" dim="Volume" quantityType="0" />
-                    <MoleculeAmount id="3-mvjTkkBky2YGOmhNBhsA" name="Drug" icon="Drug" persistable="0" isFixedValue="0" formula="5aeVh_2PME-6uVXm-e4tKQ" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="430rChYf1kmRZtGhW4iNGA" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Parameter id="qB4AnxXKakqWg1Come4YKQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="z6tXPGLtXUGlfLpPF4-n9g" dim="Dimensionless" quantityType="0" />
-                        <Observer id="mWqo5Fmn3E2RNks0jkv2kw" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Drug, Observer" />
-                      </Children>
-                    </MoleculeAmount>
-                    <MoleculeAmount id="OwcNlUslq0GJ9ITmdhV0VA" name="Cyp" icon="Enzyme" persistable="0" isFixedValue="0" formula="wb5yCXJZxUeVY_7iSBmoSg" dim="Amount" quantityType="Enzyme" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="i63Caiy2uUuh4jrt-wjmyQ" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" formula="LU6-Q7ay2UiHmpRzpmRf6g" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="1q99IxlTRUeJwM31Vveu8w" name="Relative expression out." description="Relative Expression that will be used in the simulation" persistable="0" isFixedValue="0" formula="GtBZCb_uvUKgURPKDkyZKA" dim="Fraction" quantityType="0" />
-                        <Parameter id="PC-nhK9PyEGQOAyx_d8b4A" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" persistable="0" isFixedValue="0" formula="Qv2OyMi-nU-kPqJ48WVuVw" dim="Fraction" quantityType="0" />
-                        <Parameter id="Rnkoo6u7wkuGSRfVfyWjEQ" name="Relative expression" description="Relative expression" persistable="0" isFixedValue="0" formula="iUzjEbj_NkSh4u8TNBhFgQ" dim="Fraction" quantityType="0" />
-                        <Parameter id="xecmdrujaEOQ6ZgbaWnVFw" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Observer id="QollzJ9U-Ume-An2LZZfzA" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Enzyme, Observer" />
-                      </Children>
-                    </MoleculeAmount>
-                    <MoleculeAmount id="EXLUIRNGvESh7W3JVdAxjw" name="Drug-Cyp Metabolite" persistable="0" isFixedValue="0" formula="kMXgnoNhTkyetyfiGfKJ_g" dim="Amount" quantityType="Metabolite" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="-jG9PQe-8E6o9arM-P4zew" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Observer id="vtjvqbpZ9kydmQy0gKOe6Q" name="Fraction of dose" description="Metabolized fraction of administered dose" persistable="1" isFixedValue="0" formula="aUoTQ3n3a0OShljd8bUj3w" dim="Fraction" quantityType="Metabolite, Observer" />
-                      </Children>
-                    </MoleculeAmount>
-                    <Reaction id="jk9Eef8Va0-4BTyp11niDQ" name="Cyp-ME" icon="Metabolism" mode="Logical" containerType="Other" dimension="Dimensionless" formula="NrKgrsKmwkiGET1q7OIPYg">
-                      <Educts>
-                        <ReactionPartner stoichiometricCoefficient="1" partner="3-mvjTkkBky2YGOmhNBhsA" />
-                      </Educts>
-                      <Products>
-                        <ReactionPartner stoichiometricCoefficient="1" partner="EXLUIRNGvESh7W3JVdAxjw" />
-                      </Products>
-                      <ModifierNames>
-                        <ModifierNamesChild>Cyp</ModifierNamesChild>
-                      </ModifierNames>
-                    </Reaction>
-                  </Children>
-                </Container>
-                <Container id="bC2pK9qHBUKn8mZbyhrQUA" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="BloodCells" />
-                    <Tag value="Pancreas" />
-                    <Tag value="Portal Vein Supplying Organ" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="vKL_JZPYu0CqPq1iy7Nb8g" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="owgI66XQcE2ClB4BHV50ew" dim="Volume" quantityType="0" />
-                    <Parameter id="TUGbwHy3nkeoBdbT55ZdQQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="tFZiRJ-Sv0qf0gsV7ycmYw" dim="Volume" quantityType="0" />
-                    <MoleculeAmount id="9968Lq-A-0-c-nNV7nhWCA" name="Drug" icon="Drug" persistable="0" isFixedValue="0" formula="OLpdwqkrBUCsIwXtY8mn6Q" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="L7TjRe5xdUatptU8dRr5Aw" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Parameter id="kWnkPScmQUivVKRMkZ61MQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="RocL2mxQ10aBRk7VJW0Stg" dim="Dimensionless" quantityType="0" />
-                        <Observer id="U8DlYqqXu0G_s0zeyoYG8w" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Drug, Observer" />
-                      </Children>
-                    </MoleculeAmount>
-                    <MoleculeAmount id="EyP2SZKKAE6BgnXfANA3aw" name="Cyp" icon="Enzyme" persistable="0" isFixedValue="0" formula="wb5yCXJZxUeVY_7iSBmoSg" dim="Amount" quantityType="Enzyme" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="gdhzdO7AF0CTceHFgiAjwA" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" formula="WwsE40RFYE6AtsVOoo6U5Q" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="0FnxhvY97EuMqJwqp6WjpQ" name="Relative expression out." description="Relative Expression that will be used in the simulation" persistable="0" isFixedValue="0" formula="GtBZCb_uvUKgURPKDkyZKA" dim="Fraction" quantityType="0" />
-                        <Parameter id="OdYiJLxK60aLHUML_86HaA" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" persistable="0" isFixedValue="0" formula="FTxLv_b4CkKigLwWdcA4xg" dim="Fraction" quantityType="0" />
-                        <Parameter id="URs-2-HMVUKXmBofsAZg5A" name="Relative expression" description="Relative expression" persistable="0" isFixedValue="0" formula="_J3C13ewoUatoCS2w-zxeg" dim="Fraction" quantityType="0" />
-                        <Parameter id="as3agqtvjUGQWw-_ndTUzQ" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Observer id="rgJJz0RUoUiAsut_pmW1wg" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Enzyme, Observer" />
-                      </Children>
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-              <Tags>
-                <Tag value="Skin" />
-                <Tag value="TissueOrgan" />
-              </Tags>
-              <Children>
-                <Parameter id="B0JqlTDaaUuO0dygICp5Zw" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" formula="RIZT3A90qkOKybqCwH5Tuw" dim="Volume" quantityType="0" />
-                <Parameter id="WY_mulzV3EyrcansxwNpaw" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" formula="FbGzbaLst0K5o2gc_gSjaQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="VG3uDrRLokmDz7uKSRXE5w" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" formula="mVEWvGqrgE-KcEv8JHNkQw" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="fqpFs0nYLkmPC5D5zufpFA" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" persistable="0" isFixedValue="0" formula="63lFnMt5G0KIgbnrMPz54w" dim="Dimensionless" quantityType="0" />
-                <Parameter id="0yXecKeHhUWjx3mgQ7OODg" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" formula="5ndmGKNcn0CYy1sNVPYd6w" dim="Density" quantityType="0" />
-                <Parameter id="LhdGxP_-T0abBsB9Da2Hrw" name="Peripheral blood flow fraction" description="Blood flow fraction in organ used for calculation of peripheral venous blood concentrations" persistable="0" isFixedValue="0" formula="sYrdN4lpmkOQNBu1y5pkRw" dim="Fraction" quantityType="0" />
-                <Parameter id="wk9pU8JOVkSLMkZWENfHJg" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" formula="xnyv67oG1UCP-sNafv9Qbw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="66qtStUtjkmvM5I4SBQQ_w" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" formula="m7Zmuqeu7UK_-WbpBoM8JA" dim="Nanolength" quantityType="0" />
-                <Parameter id="_a3G83QRHECANIeMOaKjpQ" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" formula="GzHw5Az8m0-JH06aKHzH4Q" dim="Nanolength" quantityType="0" />
-                <Parameter id="VCAaDIPgV0ikCZHrzvwRxQ" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" formula="ddY2eSJgn0qGDPBs_sK4iw" dim="HydraulicConductivity" quantityType="0" />
-                <Parameter id="l98yi2Czc0C6CBoPAuQ3ag" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" formula="kJ1Lf6uzJEyVhVn4c4nSnQ" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="zks7rbNuSUaMYkyy_dMHiA" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" formula="cOoeNxWu5E6XgX4Zf1vosg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="ZAUHcCe700W8YXgMXxg42Q" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" formula="9Jo6VicXCEqqO1zvmhRwew" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="1jM_5teyQkeXnrvXewKT-w" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="yx6YfJuscEey7B4pirlovA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="vGHgc_weJkiNAC2-hwPutA" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="lvtFbNorUk-qFi-CiD6GAg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="o8cttbdZpkCkBRFFrRreUw" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" formula="4C72UXnDIkGpOYeyBFJfEQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="eBA63JXSe0KtMEtIqzhMDg" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="XOPuISC6XkKT3B-9irRZfQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="8omiqtKjOUeb7syP5MYOiw" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="-Dwql3R0iUGs1U_-3nm2Ag" dim="Dimensionless" quantityType="0" />
-                <Parameter id="-h_qtNeRS06allURfA19qg" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="lVnkUMIh7UuB4esOziAcmg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="L-sIoQoF9kOT_GIIQof8Gw" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="qCVFMr2YjEOPOIacY3LkdQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="57pUjSt0BUye5xOOYeejZw" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="yI9sMucD4kSTi-1VomomJA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="SVm2hvDaA0y0tpYfyjH_Rw" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="3SKdXa8jzE231IJT3wJYeg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="b55gbeydJ02Ck0McCEDkhA" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="r-EKJm5ICE6Kb-gdFJWmMQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="0ifS2vwXbECJo0f-wVPj2A" name="Protein mass/g tissue" description="Total protein content per gram tissue" persistable="0" isFixedValue="0" formula="i1FKcmxlMESsdbNVY3RGWg" dim="MassProteinPerTissue" quantityType="0" />
-                <Parameter id="7NhFGxXxdUenoMAEcjbgEA" name="Number of cells/g tissue" description="Number of cells per gram tissue" persistable="0" isFixedValue="0" formula="0KP44ivPS0WDIFrdUg1jlQ" dim="CellQuantityPerTissue" quantityType="0" />
-                <Parameter id="epAn80Hufk-7eJvqBwlVMw" name="Microsomal protein mass/g tissue" description="Microsomal protein content per gram tissue" persistable="0" isFixedValue="0" formula="6N8DIPuOmkSFQ_CFeK500w" dim="MassProteinPerTissue" quantityType="0" />
-                <Parameter id="xgx4_j1_lU6y-G4GXqhrZQ" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" formula="P7eMZS1VdECf_Tkr25N8zA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="oRR6fDUaqU6-ljoUq40KhQ" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="KjhnzaRP-0qDkn30K2D39w" dim="Dimensionless" quantityType="0" />
-                <Parameter id="yjRnWC9CfU2Q4m0Da2GdcA" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="DLQLko_woE6NqL-idpbfrQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="44XdoTsoH0CG-x_-nrlX-A" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="mtmtMp5LwkCIPDZDD_83IQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="vavUj7QqLEanrKuR1IQBvg" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="4Br34i6x9kOhgElmuMSsAg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="jjoVkv8Ja06YVXHn7A8clA" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="zbEWsSpHQUeaGUNKYUXrdg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="9xs4rY-YMECdG0sE5snsrQ" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="cnzsWk9JuUWIilRvCD9P8A" dim="Dimensionless" quantityType="0" />
-                <Parameter id="5Jbg6_K6q0S7QoWKopBBtQ" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="E017osfQ0k-qbTdQAsquaA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="-oFYjXbAxE-j3imrVgMlVA" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="zc_52Jj6AEGLwMaUliwORg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="cESENMB6pUSKqWyRQFQV_Q" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="oUUtk2qQaUaRTJRrCxNpdg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="e5QQgOPVuUe22Qf4Jzn51w" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="rNM8crB9IkyQJZ_tsarXPw" dim="Dimensionless" quantityType="0" />
-                <DistributedParameter id="pEmD5qqfIUOJFZ1orcdb4w" name="Volume" description="Volume of organ or compartment" persistable="1" isFixedValue="0" formula="s1H0RfXIAUaZ9nXY3FJARw" dim="Volume" quantityType="0" mode="Logical">
-                  <Children>
-                    <Parameter id="S-YWZQAa30CydPE0WPYM-g" name="Percentile" persistable="0" isFixedValue="0" formula="asQRUthbm0SGo1NJUfN4qw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="Xy9pVyJczUaCk9h3AHs7Bw" name="Mean" persistable="0" isFixedValue="0" formula="dbgUYRTaV0e9su1YAes6yA" dim="Volume" quantityType="0" />
-                    <Parameter id="S3zKYEt1XUWcCmpzCP95ng" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" formula="BEm6QkChw0ewpPqOwAOWLg" dim="Volume" quantityType="0" />
-                  </Children>
-                </DistributedParameter>
-                <DistributedParameter id="iS5x1n5Aqku7rwGUbpP9jg" name="Specific blood flow rate" description="Blood flow rate normalized to the organ volume" persistable="1" isFixedValue="0" formula="SBRNwS8S0ky4k1wZuZBkkw" dim="Flow (volume) per organ weight" quantityType="0" mode="Logical">
-                  <Children>
-                    <Parameter id="7yM4Hlh2JEO6K5E8IGBA5Q" name="Percentile" persistable="0" isFixedValue="0" formula="mFqTkHKvdEi6JO60YFWEfQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="tMYN7tRO30qAV2I1cKIfIQ" name="Mean" persistable="0" isFixedValue="0" formula="xCe7uhkGSUqiHh75HEMUaA" dim="Flow (volume) per organ weight" quantityType="0" />
-                    <Parameter id="rfGSIs0XakC6a12rqMWHCA" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" formula="qkUY6gnvf02SMp65gXKhsw" dim="Flow (volume) per organ weight" quantityType="0" />
-                  </Children>
-                </DistributedParameter>
-                <Container id="y3op8mU0PEKqOFIjtlmvxA" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Plasma" />
-                    <Tag value="Skin" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="hjeea47a-0OmQa1tLLbncg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="owgI66XQcE2ClB4BHV50ew" dim="Volume" quantityType="0" />
-                    <Parameter id="9FTVoPNfm06HX5qjYtEPzQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="rbp4e7PXpUyuD1ZtA8Ocxw" dim="Volume" quantityType="0" />
-                    <MoleculeAmount id="smW_5fUV7Uil14J2vlu7cA" name="Drug" icon="Drug" persistable="0" isFixedValue="0" formula="W4BP1zoOtEmjYwQBRaaHxw" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="V76teHoRJEmz3mSf9f4F_w" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Parameter id="NtrWEfFlbEa4RQAG7-HFsg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="LEycIntGL06kWEEOthwN9g" dim="Dimensionless" quantityType="0" />
-                        <Observer id="7fWjpzM0FEGbvLZGvEgMKg" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Drug, Observer" />
-                      </Children>
-                    </MoleculeAmount>
-                    <MoleculeAmount id="vVtJUSDaT0G9RBGlRW5smQ" name="Cyp" icon="Enzyme" persistable="0" isFixedValue="0" formula="wb5yCXJZxUeVY_7iSBmoSg" dim="Amount" quantityType="Enzyme" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="o1Z5fij7hUeKF3pKqlq2MQ" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" formula="GM2VSzBOu0iPAl9N_i-CjA" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="PhQJMnnGw0KZjkeNpSEd2w" name="Relative expression out." description="Relative Expression that will be used in the simulation" persistable="0" isFixedValue="0" formula="GtBZCb_uvUKgURPKDkyZKA" dim="Fraction" quantityType="0" />
-                        <Parameter id="hLwd19a14E6GY8HWecOBIg" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" persistable="0" isFixedValue="0" formula="Qv2OyMi-nU-kPqJ48WVuVw" dim="Fraction" quantityType="0" />
-                        <Parameter id="6pr67AySL0CbZSdQeBgljw" name="Relative expression" description="Relative expression" persistable="0" isFixedValue="0" formula="iUzjEbj_NkSh4u8TNBhFgQ" dim="Fraction" quantityType="0" />
-                        <Parameter id="1zVrlmJEokuq_XqCj54NAg" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Observer id="IefJFuNJD0SMzCTEIq-tNQ" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Enzyme, Observer" />
-                      </Children>
-                    </MoleculeAmount>
-                    <MoleculeAmount id="_zeB3z71iUuf0zWOu8wRfQ" name="Drug-Cyp Metabolite" persistable="0" isFixedValue="0" formula="1t-dTG3GQ0GSNOujSy2xzQ" dim="Amount" quantityType="Metabolite" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="ucNt0OtjUEiY9LbLlVvYeQ" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Observer id="qRE234ivZ0aH4JfFOoZj_w" name="Fraction of dose" description="Metabolized fraction of administered dose" persistable="1" isFixedValue="0" formula="aUoTQ3n3a0OShljd8bUj3w" dim="Fraction" quantityType="Metabolite, Observer" />
-                      </Children>
-                    </MoleculeAmount>
-                    <Reaction id="ZCe3uFn5m0y8j68gfDM3Yw" name="Cyp-ME" icon="Metabolism" mode="Logical" containerType="Other" dimension="Dimensionless" formula="NrKgrsKmwkiGET1q7OIPYg">
-                      <Educts>
-                        <ReactionPartner stoichiometricCoefficient="1" partner="smW_5fUV7Uil14J2vlu7cA" />
-                      </Educts>
-                      <Products>
-                        <ReactionPartner stoichiometricCoefficient="1" partner="_zeB3z71iUuf0zWOu8wRfQ" />
-                      </Products>
-                      <ModifierNames>
-                        <ModifierNamesChild>Cyp</ModifierNamesChild>
-                      </ModifierNames>
-                    </Reaction>
-                  </Children>
-                </Container>
-                <Container id="CkLwUzDt9Eqp-pbnsLmpig" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="BloodCells" />
-                    <Tag value="Skin" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="vef7nyE9s0S0kLGh2giljw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="owgI66XQcE2ClB4BHV50ew" dim="Volume" quantityType="0" />
-                    <Parameter id="qg_aRAY_D0S3P21Azilmtg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="tFZiRJ-Sv0qf0gsV7ycmYw" dim="Volume" quantityType="0" />
-                    <MoleculeAmount id="uPQUKjkvEkeQDYVMvdnypA" name="Drug" icon="Drug" persistable="0" isFixedValue="0" formula="VradgfVvoEe_KvArTj7F0Q" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="Dqk4U3QKaEi-OSyWn_QF9w" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Parameter id="K6pwfjk-c02fJocQpHiQ6g" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="YVGzv7yv-EK4Z_YAJOvV7w" dim="Dimensionless" quantityType="0" />
-                        <Observer id="tIQzn0zwFkumfAkg8nFn2w" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Drug, Observer" />
-                      </Children>
-                    </MoleculeAmount>
-                    <MoleculeAmount id="xVSFemJfPEKYqFnTAFo2hg" name="Cyp" icon="Enzyme" persistable="0" isFixedValue="0" formula="wb5yCXJZxUeVY_7iSBmoSg" dim="Amount" quantityType="Enzyme" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="G2nOVJpOT0qiPnWZ7MNHXg" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" formula="Kk7-UJkqukWgH9vfyJdgfg" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="5DyTKrzIL0iKYAq5591L2A" name="Relative expression out." description="Relative Expression that will be used in the simulation" persistable="0" isFixedValue="0" formula="GtBZCb_uvUKgURPKDkyZKA" dim="Fraction" quantityType="0" />
-                        <Parameter id="Ogr0WIL2CUCPnK8ImNKSEQ" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" persistable="0" isFixedValue="0" formula="FTxLv_b4CkKigLwWdcA4xg" dim="Fraction" quantityType="0" />
-                        <Parameter id="13lHOP-vLE60H7hoegdC0Q" name="Relative expression" description="Relative expression" persistable="0" isFixedValue="0" formula="_J3C13ewoUatoCS2w-zxeg" dim="Fraction" quantityType="0" />
-                        <Parameter id="9Z_vv2rHfUmXJl7FS1ummg" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Observer id="Mr8DEd9OpUi9FDUg2ypGew" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Enzyme, Observer" />
-                      </Children>
-                    </MoleculeAmount>
-                    <MoleculeAmount id="L1eYz5ilNEuBwkCkNogmcA" name="Drug-Cyp Metabolite" persistable="0" isFixedValue="0" formula="dIsWZoc68kidXgPuJ5m9ug" dim="Amount" quantityType="Metabolite" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="_rGJLn6YE0m9WA8wTehJew" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Observer id="m-21UTc9EkiC6d02663H4g" name="Fraction of dose" description="Metabolized fraction of administered dose" persistable="1" isFixedValue="0" formula="aUoTQ3n3a0OShljd8bUj3w" dim="Fraction" quantityType="Metabolite, Observer" />
-                      </Children>
-                    </MoleculeAmount>
-                    <Reaction id="7KNz8Wu7S0KfVZPvf3GdAg" name="Cyp-ME" icon="Metabolism" mode="Logical" containerType="Other" dimension="Dimensionless" formula="NrKgrsKmwkiGET1q7OIPYg">
-                      <Educts>
-                        <ReactionPartner stoichiometricCoefficient="1" partner="uPQUKjkvEkeQDYVMvdnypA" />
-                      </Educts>
-                      <Products>
-                        <ReactionPartner stoichiometricCoefficient="1" partner="L1eYz5ilNEuBwkCkNogmcA" />
-                      </Products>
-                      <ModifierNames>
-                        <ModifierNamesChild>Cyp</ModifierNamesChild>
-                      </ModifierNames>
-                    </Reaction>
-                  </Children>
-                </Container>
-                <Container id="ijwnJLM3Sk6gFSbU62epSA" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Interstitial" />
-                    <Tag value="Skin" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="lKJuUmMv8UKsKcaSDVM89w" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="owgI66XQcE2ClB4BHV50ew" dim="Volume" quantityType="0" />
-                    <Parameter id="t1-RCylzM0C8l_35VlXkHg" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="4VSppd3W3E6-12kllCJ0Mg" dim="Volume" quantityType="0" />
-                    <Parameter id="KPHwNUxad06sOJAV2k1_kQ" name="pH" description="pH" persistable="0" isFixedValue="0" formula="tKjHIxsi60KoHEPhXQBZrw" dim="Dimensionless" quantityType="0" />
-                    <MoleculeAmount id="YCuAfRjSFECzqzSBBgUTCQ" name="Drug" icon="Drug" persistable="0" isFixedValue="0" formula="7YC6IwFmAUybDYNGb8UOjw" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="boUAkv3M1USFSxi9zdimZA" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Parameter id="Ry66usQsNkSe-73YTs0m0g" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="YjNo3RbIYkWN-r8liu1jvw" dim="Dimensionless" quantityType="0" />
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-                  <Tags>
-                    <Tag value="Intracellular" />
-                    <Tag value="Skin" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="m5y7tMszXkesrtRTRNUsHQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="M9arQg_qfEGMA7JdlSXkFA" dim="Volume" quantityType="0" />
-                    <Parameter id="e7h-zE8B-kiWKliduQSTKQ" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="3l84whkuX0S7xUUHglUQpg" dim="Volume" quantityType="0" />
-                    <Parameter id="eWsY0JGI9kyYsgYtGEKADw" name="pH" description="pH" persistable="0" isFixedValue="0" formula="KwG_Kcn1P0emiufiXPH_zw" dim="Dimensionless" quantityType="0" />
-                    <MoleculeAmount id="1O_wMQkPE0Kja-I5ZURsEw" name="Drug" icon="Drug" persistable="0" isFixedValue="0" formula="0A4dvLMuEUmULxfDziU_8Q" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="TfyW0clmsE2V0c5bInwTAg" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Parameter id="_4G3s0LHkkqVvdtwV0RjCQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="_XRinPgxw0GitohFQ_4TwA" dim="Dimensionless" quantityType="0" />
-                        <Observer id="62TFXkcNt0mxyR7BB3pV5g" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Drug, Observer" />
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-                    <MoleculeAmount id="-CTpKxYQsU6_pmyuSP_RKA" name="Cyp" icon="Enzyme" persistable="0" isFixedValue="0" formula="wb5yCXJZxUeVY_7iSBmoSg" dim="Amount" quantityType="Enzyme" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="S_aL8LzOSE6zgNMEHUaZbw" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" formula="vmF4KG39bUSzkp_3EScrWw" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="IJPG6xPvH0OjO5w-nnT47Q" name="Relative expression out." description="Relative Expression that will be used in the simulation" persistable="0" isFixedValue="0" formula="GtBZCb_uvUKgURPKDkyZKA" dim="Fraction" quantityType="0" />
-                        <Parameter id="kfUBRfIpnkGiIVzLZhEH5g" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" persistable="0" isFixedValue="0" formula="3d_Kkv4AyUSqBjcz-HkVnA" dim="Fraction" quantityType="0" />
-                        <Parameter id="qnabhd-fJEuGpYAKBaEljg" name="Relative expression" description="Relative expression" persistable="0" isFixedValue="0" formula="gpiQI4dYrE2I2DK78egGaw" dim="Fraction" quantityType="0" />
-                        <Parameter id="u3X1qYi270CxO6utLp9sSA" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Observer id="ZReDvDDzLkC25iwGQdgZCw" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Enzyme, Observer" />
-                      </Children>
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-                    <MoleculeAmount id="noogvwqyhkueNFFlMIfSYQ" name="Drug-Cyp Metabolite" persistable="0" isFixedValue="0" formula="fCTQntNAAUeaTBtensOodQ" dim="Amount" quantityType="Metabolite" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="Eo3drJXGP0-e7HOj10HQ-A" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Observer id="GPCN9Wr5aEWRiEIpdDoc4A" name="Fraction of dose" description="Metabolized fraction of administered dose" persistable="1" isFixedValue="0" formula="aUoTQ3n3a0OShljd8bUj3w" dim="Fraction" quantityType="Metabolite, Observer" />
-                      </Children>
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-                    <Reaction id="2mamXZ2y8kayoKIIVMgqVw" name="Cyp-ME" icon="Metabolism" mode="Logical" containerType="Other" dimension="Dimensionless" formula="NrKgrsKmwkiGET1q7OIPYg">
-                      <Educts>
-                        <ReactionPartner stoichiometricCoefficient="1" partner="1O_wMQkPE0Kja-I5ZURsEw" />
-                      </Educts>
-                      <Products>
-                        <ReactionPartner stoichiometricCoefficient="1" partner="noogvwqyhkueNFFlMIfSYQ" />
-                      </Products>
-                      <ModifierNames>
-                        <ModifierNamesChild>Cyp</ModifierNamesChild>
-                      </ModifierNames>
-                    </Reaction>
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-                <Container id="VONe5LHGk0GSWR_KyoPh5Q" name="Drug" mode="Logical" containerType="Molecule">
-                  <Children>
-                    <Observer id="81q5zUql0Eu-xIgvLsGZzw" name="Interstitial Unbound" description="Interstitial Unbound" persistable="1" isFixedValue="0" formula="sb2EI4hIhEWxy5ZYMY2QFw" dim="MolarConcentration" quantityType="Drug, Observer" />
-                    <Observer id="wFqDDQtWSkOkIkFa0emmyg" name="Intracellular Unbound" description="Intracellular Unbound" persistable="1" isFixedValue="0" formula="F5kFVlFTnEmJToE6fKssfA" dim="MolarConcentration" quantityType="Drug, Observer" />
-                    <Observer id="ICx2vDN8WkiYJvMFXT15rw" name="Tissue" description="Tissue" persistable="1" isFixedValue="0" formula="wztK_G9P_0mMbsEE9LSVMw" dim="MolarConcentration" quantityType="Drug, Observer" />
-                  </Children>
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-            </Container>
-            <Container id="vNUTVCFmR02r5FoxPy_wNA" name="Spleen" description="Spleen" icon="Spleen" mode="Logical" containerType="Organ">
-              <Tags>
-                <Tag value="Spleen" />
-                <Tag value="Portal Vein Supplying Organ" />
-                <Tag value="TissueOrgan" />
-              </Tags>
-              <Children>
-                <Parameter id="2y-TJmwC30CAo6khK_wAPw" name="Volume (endothelium)" description="Volume of  vascular endothelium" persistable="0" isFixedValue="0" formula="caMLwM2ZkkafQH-boltkXg" dim="Volume" quantityType="0" />
-                <Parameter id="8ykAElTb10Kx7JmXxjI64Q" name="Fraction intracellular" description="Fraction of intracellular space of the organ" persistable="0" isFixedValue="0" formula="FbGzbaLst0K5o2gc_gSjaQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="iswnx7Abgkiedca6jRrAvA" name="Blood flow rate" description="Organ blood flow rate" persistable="0" isFixedValue="0" formula="mVEWvGqrgE-KcEv8JHNkQw" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="28YswaVsQEGCOv723jU8CQ" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" persistable="0" isFixedValue="0" formula="e8oEgaT5w0KVBbUP4XrlZg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="rwFLH1u4X0iWVOczFehZUA" name="Density (tissue)" description="Density of tissue" persistable="0" isFixedValue="0" formula="qAT32Q9JUkCl-yJfYf-k-A" dim="Density" quantityType="0" />
-                <Parameter id="2nw4kXEAOUmwJDS4sbC1-w" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" persistable="0" isFixedValue="0" formula="SmtFxkNNh02qo0lpoibloQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="AtiNqurbcEycXt3AT6R3dA" name="Radius (large pores)" description="Large endothelial pores radius" persistable="0" isFixedValue="0" formula="aoTKJXhL002N7fXo8TZHSA" dim="Nanolength" quantityType="0" />
-                <Parameter id="QXMMDST_a0S6mx_4pzd23g" name="Radius (small pores)" description="Small endothelial pores radius" persistable="0" isFixedValue="0" formula="MGk1cXyGMUS4mCl4D6m-wg" dim="Nanolength" quantityType="0" />
-                <Parameter id="_BS4MRpw6EivJwwcjpBZkg" name="Lymph flow rate" description="Lymph flow rate" persistable="0" isFixedValue="0" formula="xju7TPp9xUKdYRywULM_NQ" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="xFqlniQoN0qQsqIjKFM3aw" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" persistable="0" isFixedValue="0" formula="AIrAFhfwq0yCzOk1ZUlzQA" dim="HydraulicConductivity" quantityType="0" />
-                <Parameter id="wiymNb049Eyd7_z7mn0JFw" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" persistable="0" isFixedValue="0" formula="oMtQDMJfBkq-cT9GsW29Dg" dim="Flow (volume)" quantityType="0" />
-                <Parameter id="z_9ZYtc8AU6NkbO6xlwaMA" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" persistable="0" isFixedValue="0" formula="gTDOkFLuMUyzOO9xTEjDZg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="iEljzacbpU-ulEiUkOD8MA" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="MbmeFwR500Kh7FGfWFLx_Q" dim="Dimensionless" quantityType="0" />
-                <Parameter id="jjnZlyxalUK83d3CO9v8wg" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="VCziTIr1cUCpuYKjR2Kw0w" dim="Dimensionless" quantityType="0" />
-                <Parameter id="6J4b4Z90qEK5EGx6-kVjrw" name="Fraction vascular" description="Fraction of vascular space of the organ" persistable="0" isFixedValue="0" formula="aQDTYfYQW0Gpxy02Zyu8NA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="AjJhRtbcwEaEeTUxzXdhJg" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="k_OGJAdXAUSBRVkj2Y0XzA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="AAF3jM6PO0mI-rjrHVgihA" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="8Fef8-MvOEOj0CE_3H4i1A" dim="Dimensionless" quantityType="0" />
-                <Parameter id="gIRERgKxK02Nhb1V8Fe0Ww" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" persistable="0" isFixedValue="0" formula="aihEzOno9U6qaFbZSrNp_Q" dim="Dimensionless" quantityType="0" />
-                <Parameter id="6N5EFuXrCUaHY-g9YyoJTg" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="xAGBAhGVC0yd96dZQHCTtA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="NyJEKLdD_UuCWRoStw-P-g" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="xS6I0ArJXkG_SmR-E5P3NA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="aaqX0O0jXkOqZlv3Y5XydA" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" persistable="0" isFixedValue="0" formula="YHorVU-nOU6yB6bzT1A4tg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="B61vsGcjYEyXG4dFSlz1Yw" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" persistable="0" isFixedValue="0" formula="2ojnWsyQHkmw-Y2ucAhVLQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="gSBedq68J0uVZsLRRmR8uw" name="Protein mass/g tissue" description="Total protein content per gram tissue" persistable="0" isFixedValue="0" formula="5Fy9xNdmDEe2JYkhvEVITQ" dim="MassProteinPerTissue" quantityType="0" />
-                <Parameter id="otEHXQsy8EGKAvRkLKsxsA" name="Number of cells/g tissue" description="Number of cells per gram tissue" persistable="0" isFixedValue="0" formula="3GNiJIPd9U2tFmY7XvAMMQ" dim="CellQuantityPerTissue" quantityType="0" />
-                <Parameter id="lByAD8I78Uq4mcZiU2a65w" name="Microsomal protein mass/g tissue" description="Microsomal protein content per gram tissue" persistable="0" isFixedValue="0" formula="PYnKDaCQuUG9Leja1b2Dtw" dim="MassProteinPerTissue" quantityType="0" />
-                <Parameter id="bbjANr2-5E6pjcXHCZ8hVg" name="Fraction interstitial" description="Fraction of interstitial space of the organ" persistable="0" isFixedValue="0" formula="ODXJSQ20l0uD4fOq-dMh7A" dim="Dimensionless" quantityType="0" />
-                <Parameter id="AIrHxS3KRUiUAuTuJ4hr8w" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="kwC7uqq7V0CGVSmwpKgBMA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="VZY4_pY4UkmTLxvkfhks-w" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="Aahszch9-E6L17odMlmiHw" dim="Dimensionless" quantityType="0" />
-                <Parameter id="FJLWk4Pr3020qmcoD45g0g" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="i8gEjQ-vz0qqwyOmO5jtSQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="JUE3GF31KEWjfVHr5h0GRw" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="Ml3pi0jRuUmxzpqY2ADw1g" dim="Dimensionless" quantityType="0" />
-                <Parameter id="PfWckgbWO0S5nQhBPBankQ" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="ftV4-2vVRUCJQ68wD7zJnQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="ksvqBBcLjUKa5zAdg6MKZg" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="C5sPgGyBlESjoaubOQRGWQ" dim="Dimensionless" quantityType="0" />
-                <Parameter id="4yLGkvgTs0WyU6z-tiSYeQ" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="8DikjQdhSEGPoyY74X9N8w" dim="Dimensionless" quantityType="0" />
-                <Parameter id="CFIN8ywWU0GLaMbDte5M6Q" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="oKPjYq0ab0-3AaRWppj8LA" dim="Dimensionless" quantityType="0" />
-                <Parameter id="E4WRDc1jiU6yoi2JFCwwSw" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" persistable="0" isFixedValue="0" formula="BrfdZEza00S9AaDGCSjmRg" dim="Dimensionless" quantityType="0" />
-                <Parameter id="qsjnTHR-vUWru1Gkwvf-xA" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" persistable="0" isFixedValue="0" formula="dSfC9o8bWkGoTN97KpT-tA" dim="Dimensionless" quantityType="0" />
-                <DistributedParameter id="ubBz-IV-MEiNEL3BI20QcQ" name="Volume" description="Volume of organ or compartment" persistable="1" isFixedValue="0" formula="o2MHJOwAyUGT7dQBG8bvgw" dim="Volume" quantityType="0" mode="Logical">
-                  <Children>
-                    <Parameter id="GylwVhZzwUSwIBUwUhHaRA" name="Percentile" persistable="0" isFixedValue="0" formula="6ltOKFXWeEiYSmShCxpjSQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="GbXAByaZDkiCd22mQKLBGw" name="Mean" persistable="0" isFixedValue="0" formula="BrJPDXVmM0ewjSccYSkj2Q" dim="Volume" quantityType="0" />
-                    <Parameter id="V-Cpjn5VBEayjrx_MJhUrw" name="GeometricDeviation" description="Geometric standard deviation of LogNormal distribution" persistable="0" isFixedValue="0" formula="0hZZ78cdkEq8CzCaFXCQiQ" dim="Dimensionless" quantityType="0" />
-                  </Children>
-                </DistributedParameter>
-                <DistributedParameter id="dh2QfX5frEmOfBqP0VQImQ" name="Specific blood flow rate" description="Blood flow rate normalized to the organ volume" persistable="1" isFixedValue="0" formula="maRUBmObpEupnZJLE72V_A" dim="Flow (volume) per organ weight" quantityType="0" mode="Logical">
-                  <Children>
-                    <Parameter id="nMcB33K9ckmUlvACCHPFiQ" name="Percentile" persistable="0" isFixedValue="0" formula="8eoP6qMRuUumf3cz1sU9-w" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="du9Y21E5w0iHaUkkPMPU0A" name="Mean" persistable="0" isFixedValue="0" formula="pkdhdKQpckeHM23NaC5keQ" dim="Flow (volume) per organ weight" quantityType="0" />
-                    <Parameter id="Ze2nq2upiUqttNiA3W8neg" name="Deviation" description="Standard deviation of Normal distribution" persistable="0" isFixedValue="0" formula="gtALpUwNME2CoqW-654miw" dim="Flow (volume) per organ weight" quantityType="0" />
-                  </Children>
-                </DistributedParameter>
-                <Container id="LZ_CQqYrBEO2uhzLfZltGA" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
-                  <Tags>
-                    <Tag value="Plasma" />
-                    <Tag value="Portal Vein Supplying Organ" />
-                    <Tag value="Spleen" />
-                  </Tags>
-                  <Children>
-                    <Parameter id="B-8hnQnsEEyhWUk3RNmVXg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" persistable="0" isFixedValue="0" formula="owgI66XQcE2ClB4BHV50ew" dim="Volume" quantityType="0" />
-                    <Parameter id="jkdPAhUfRUa3E0zc6ZI6ow" name="Volume" description="Volume of organ or compartment" persistable="0" isFixedValue="0" formula="rbp4e7PXpUyuD1ZtA8Ocxw" dim="Volume" quantityType="0" />
-                    <MoleculeAmount id="PJw6pc0knU6Z5oByDI70zA" name="Drug" icon="Drug" persistable="0" isFixedValue="0" formula="x7PSysvu3EG7qve391FHYA" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="8_RtE8kgLka7rAypSGM8SQ" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Parameter id="ijDVXCZJBUyc-lMR4wKSnQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" persistable="0" isFixedValue="0" formula="tF-kIQEB1ECaLBXuAwxQsQ" dim="Dimensionless" quantityType="0" />
-                        <Observer id="C7ZeFsu8Ak64QRQU72sYLg" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Drug, Observer" />
-                      </Children>
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-                    <MoleculeAmount id="eZu4gOzz3kivCLU-DQ98Jg" name="Cyp" icon="Enzyme" persistable="0" isFixedValue="0" formula="wb5yCXJZxUeVY_7iSBmoSg" dim="Amount" quantityType="Enzyme" mode="Logical" scaleFactor="1">
-                      <Children>
-                        <Parameter id="jkr2yYj0n0ebPjx0TE-8bg" name="Ontogeny factor" description="Ontogeny factor" persistable="0" isFixedValue="0" formula="RMF_XJOVREe6Be8R260zdQ" dim="Dimensionless" quantityType="0" />
-                        <Parameter id="3ZR5dffP2U-_rzkr0YcC1w" name="Relative expression out." description="Relative Expression that will be used in the simulation" persistable="0" isFixedValue="0" formula="GtBZCb_uvUKgURPKDkyZKA" dim="Fraction" quantityType="0" />
-                        <Parameter id="gSqAJV8TKEuzh8pCwMUXoQ" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" persistable="0" isFixedValue="0" formula="Qv2OyMi-nU-kPqJ48WVuVw" dim="Fraction" quantityType="0" />
-                        <Parameter id="XMfTDEKr3Emnsm3Tda2aeQ" name="Relative expression" description="Relative expression" persistable="0" isFixedValue="0" formula="iUzjEbj_NkSh4u8TNBhFgQ" dim="Fraction" quantityType="0" />
-                        <Parameter id="xZBErmWGckau6M8hfBCxRA" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Observer id="3W4mk-3jOEuPBOhoI4H32g" name="Concentration in container" description="Concentration of the molecule" persistable="1" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Enzyme, Observer" />
-                      </Children>
-                    </MoleculeAmount>
-                    <MoleculeAmount id="pS5BvIlvokqQMZnzOV7KnA" name="Drug-Cyp Metabolite" persistable="0" isFixedValue="0" formula="yIjYbWfDGEe59WD2M9FF4Q" dim="Amount" quantityType="Metabolite" mode="Logical" scaleFactor="1">
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-                    <Transport id="pZqID5ecHU66eYeuwndoOQ" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Other" dimension="Dimensionless" formula="QSZoI61u3E6tfArSEhsTRA" sourceAmount="-KHwz6KsaUKMJrU3wcwlsw" targetAmount="KoF_gPV3a0C8KDxsooKTTQ" />
-                  </Children>
-                </Container>
-                <Parameter id="NEYUp1WQm0uHRtwW2ADpBQ" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" formula="4duWuwlf-EWC7Z8f_FhXWQ" dim="Surface" quantityType="0" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="pKeAGZUvSkGTY8ogIR4lqw" name="Bone_int_Bone_cell" description="Neighborhood between Bone/Interstitial and Bone/Intracellular" mode="Logical" containerType="Other" firstNeighbor="UiObEggumUShC956NO9_Vg" secondNeighbor="Zd1nQyVUfk-dvBhHmV3vAg">
-              <Tags>
-                <Tag value="Bone_int_Bone_cell" />
-                <Tag value="Neighborhood: Interstitial / Intracellular" />
-              </Tags>
-              <Children>
-                <Container id="7S9sjFNYLE6Vo4MNkJX7sQ" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="MpPCWOp35UuO_dM-4K7VSA" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="xQZ40Mn0s0Wf7QlpiyG1_w" dim="Velocity" quantityType="0" />
-                    <Parameter id="VJfAGN1v40WCqlsGCAooOw" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="3-LEyoK2GEOuCEV2otw_AQ" dim="Velocity" quantityType="0" />
-                    <Parameter id="GEy9Z5vgb0-HiUOLp4eAfw" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="DIQILkkEz06QbATD24Bttw" dim="Flow (volume)" quantityType="0" />
-                    <Parameter id="Asu721uHt0K528dBAU8aOA" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="GRkU-raPfUeXS_32oxTzjQ" dim="Flow (volume)" quantityType="0" />
-                    <Parameter id="q6A50Uo20US-4taXN3jULA" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="QKADJjGIQ0W3Yk6CIARbtw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="9ONlmkzJ9ka0bQP9E2rHDQ" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="17AiOHjQiUmb4ZognmAGqA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="Mor5wf2OVU6Jagmad-Qvtg" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" formula="5fn9APqaCUKsG7o5iB8jmQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="JV0ucaiuIkmJbccVn_W_Zg" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" formula="3cJBFwQjyUqzb_kQadzpHA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="V_u7D6vtLkWVj4vipQJwyg" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" formula="7g8HxvCu1EWbOUrRhqJBsg" dim="Dimensionless" quantityType="0" />
-                    <Transport id="3LKgaRKi2UiUuwFUALxpuw" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Other" dimension="Dimensionless" formula="PuSsKcCNaUeq3F2pa9ha9w" sourceAmount="r9M8cKCM30aQBexecKBBQQ" targetAmount="C6DYncvS3kS8iYQhesM8aw" />
-                  </Children>
-                </Container>
-                <Parameter id="2dF_J_rZQE2G6Y0cqVkhnA" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" formula="rIGr-92g6kSeYTpHJVVJ3w" dim="Surface" quantityType="0" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="zwre2r09XUuOgWlYck9kmQ" name="Bone_bc_VenousBlood_bc" description="Neighborhood between Bone/Blood Cells and Venous Blood/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="9PgVSRUEFky2ekQwkIaHHw" secondNeighbor="vv8rxyxvYkasBnpcCaOSyg">
-              <Tags>
-                <Tag value="Bone_bc_VenousBlood_bc" />
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="7eG8TDgY4EinIlKR-p0zCw" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Transport id="fC2S9GfJyUGiOVIznBbeAw" name="MassTransferOrgRBC2BloodPool" description="Mass transfer from organ: Blood Cells to Arterial Blood: Blood Cells" mode="Logical" containerType="Other" dimension="Dimensionless" formula="RI5RZGQTY0eEP4LZmZaDpQ" sourceAmount="Fn6IF-t_c06tyZDdsv9GJA" targetAmount="FMF6RMb5pkyvcn1PXHNkgw" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="qL9kUbfuUEulcXEpxQfpKA" name="Bone_pls_Bone_int" description="Neighborhood between Bone/Plasma and Bone/Interstitial" mode="Logical" containerType="Other" firstNeighbor="pdisLuqFw0KHSEKiS47vmg" secondNeighbor="UiObEggumUShC956NO9_Vg">
-              <Tags>
-                <Tag value="Bone_pls_Bone_int" />
-                <Tag value="Neighborhood: Plasma / Interstitial" />
-              </Tags>
-              <Children>
-                <Container id="8DNg5y23OEuCDRy1L6C7yA" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="znrEpM65H0SErpUjaUipig" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" formula="P0Yjoba3NUKIhePElNN4IA" dim="Velocity" quantityType="0" />
-                    <Parameter id="AmCqmdBlOEuel37p26uuEw" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" formula="-DEFSC4vn0ajeww6-OP5eg" dim="Dimensionless" quantityType="0" />
-                    <Transport id="03PKywNU10S0c3d_YBpvWA" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Other" dimension="Dimensionless" formula="PQXRLnHfEU-1Q0vo9LGCjA" sourceAmount="W1-NePRLxkyUOBkmLtikoA" targetAmount="r9M8cKCM30aQBexecKBBQQ" />
-                  </Children>
-                </Container>
-                <Parameter id="yqQPmG-Q-0SMFw8NJ9DOLg" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" formula="0rgEdalDDE-tCPoTMx9Iqg" dim="Surface" quantityType="0" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="0uz4r2xTyUG1Dkf2nsYNJA" name="Bone_pls_VenousBlood_pls" description="Neighborhood between Bone/Plasma and Venous Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="pdisLuqFw0KHSEKiS47vmg" secondNeighbor="R5jgBt3okEeUHClw7hT2EA">
-              <Tags>
-                <Tag value="Bone_pls_VenousBlood_pls" />
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="KhCXMaGJ4UmXeWrn3BCAQQ" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Transport id="jxUa158jDU-V3o241CaU-g" name="MassTransferOrgPl2BloodPool" description="Mass transfer from organ: Plasma to Venous Blood: Plasma" mode="Logical" containerType="Other" dimension="Dimensionless" formula="r5ujzZIb4UmHjwsKmQ0fUw" sourceAmount="W1-NePRLxkyUOBkmLtikoA" targetAmount="0z8uD-0gmE61mkI_fDKAZQ" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="JrVRwUYchkehR8C7Px_Yiw" name="Bone_pls_Bone_bc" description="Neighborhood between Bone/Plasma and Bone/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="pdisLuqFw0KHSEKiS47vmg" secondNeighbor="9PgVSRUEFky2ekQwkIaHHw">
-              <Tags>
-                <Tag value="Bone_pls_Bone_bc" />
-                <Tag value="Neighborhood: Plasma / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="Z3hiIV2TwkqfB2stWppe8A" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Transport id="AWK4za_9bkq6iwcrM7gzgg" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Other" dimension="Dimensionless" formula="L0zfeIFJ4k2dmevhD0HkLA" sourceAmount="W1-NePRLxkyUOBkmLtikoA" targetAmount="Fn6IF-t_c06tyZDdsv9GJA" />
-                  </Children>
-                </Container>
-                <Parameter id="chWArpGvpkWgNn0v7GgICQ" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" formula="MBY2irtvo0aU4OlrnOOOzg" dim="Surface" quantityType="0" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="FLlBvkeAcEmpKaiN1rmbsw" name="Brain_pls_Brain_bc" description="Neighborhood between Brain/Plasma and Brain/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="OMWgkiYM0UGkJuNf5FXsQQ" secondNeighbor="xcX6xUb0qUCOHyUT7SoyuQ">
-              <Tags>
-                <Tag value="Brain_pls_Brain_bc" />
-                <Tag value="Neighborhood: Plasma / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="R11b4AZwYUugVrDrv532NA" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Transport id="5Z6sRuaA-U-eDZX6crOeMg" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Other" dimension="Dimensionless" formula="_YGPctRTuUuHG8HaGvKC7g" sourceAmount="yBZAPigg6kqjtxtyvw6vCw" targetAmount="M6OtacKy4UGZaIp9ew6wbw" />
-                  </Children>
-                </Container>
-                <Parameter id="e_15gOBsnUivmKFHzuQdtw" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" formula="VykXM9ZZt0SLhPZYnREkVA" dim="Surface" quantityType="0" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="2U8XolmdVEaXKo_cGMUuZw" name="Brain_pls_VenousBlood_pls" description="Neighborhood between Brain/Plasma and Venous Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="OMWgkiYM0UGkJuNf5FXsQQ" secondNeighbor="R5jgBt3okEeUHClw7hT2EA">
-              <Tags>
-                <Tag value="Brain_pls_VenousBlood_pls" />
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="gHeexLy2CUay4o3N8d-YGQ" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Transport id="zSVFIXmVBkmG5hnjBlywZw" name="MassTransferOrgPl2BloodPool" description="Mass transfer from organ: Plasma to Venous Blood: Plasma" mode="Logical" containerType="Other" dimension="Dimensionless" formula="ofT7TDKF-kqgZ_sqsi9UkA" sourceAmount="yBZAPigg6kqjtxtyvw6vCw" targetAmount="0z8uD-0gmE61mkI_fDKAZQ" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="j5Rjj38yhU2oaYgSxq7clA" name="Brain_pls_Brain_int" description="Neighborhood between Brain/Plasma and Brain/Interstitial" mode="Logical" containerType="Other" firstNeighbor="OMWgkiYM0UGkJuNf5FXsQQ" secondNeighbor="X_p8GZ1SvUWpeiLCVVxKDw">
-              <Tags>
-                <Tag value="Brain_pls_Brain_int" />
-                <Tag value="Neighborhood: Plasma / Interstitial" />
-              </Tags>
-              <Children>
-                <Container id="GTFI2HYuDkOj6DSR1RTcXg" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="qnuc3F91WEC87tCKZJOM4w" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" formula="-DEFSC4vn0ajeww6-OP5eg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="BpMh3wr8IE6rjwlxmhzeVA" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" formula="lDLmJrV660KQvRyGBt7p2g" dim="Velocity" quantityType="0" />
-                    <Transport id="mYSXs_oqHUScc1nUd60DCw" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Other" dimension="Dimensionless" formula="kFa9AoBsek-d9hTe4k-0sQ" sourceAmount="yBZAPigg6kqjtxtyvw6vCw" targetAmount="Sz0YCzmSPkGYP_QKdWyWcA" />
-                  </Children>
-                </Container>
-                <Parameter id="fTO-9_lB4EKCkTn4LGE_Mg" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" formula="t2S59S06gU2evYhuzKhwGA" dim="Surface" quantityType="0" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="9oqne8vKLkmHgDUOpdUrIw" name="Brain_bc_VenousBlood_bc" description="Neighborhood between Brain/Blood Cells and Venous Blood/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="xcX6xUb0qUCOHyUT7SoyuQ" secondNeighbor="vv8rxyxvYkasBnpcCaOSyg">
-              <Tags>
-                <Tag value="Brain_bc_VenousBlood_bc" />
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="h9myP5_nfEyH89uGTWJcIA" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Transport id="FmDn7bPipEOPJ5Rr0V69NA" name="MassTransferOrgRBC2BloodPool" description="Mass transfer from organ: Blood Cells to Arterial Blood: Blood Cells" mode="Logical" containerType="Other" dimension="Dimensionless" formula="fkPYKrhI4EupVOHYq889yA" sourceAmount="M6OtacKy4UGZaIp9ew6wbw" targetAmount="FMF6RMb5pkyvcn1PXHNkgw" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="doYALIZTAE20GxrLaXab7w" name="Brain_int_Brain_cell" description="Neighborhood between Brain/Interstitial and Brain/Intracellular" mode="Logical" containerType="Other" firstNeighbor="X_p8GZ1SvUWpeiLCVVxKDw" secondNeighbor="Eac_25qTukyJb8zKF35SXw">
-              <Tags>
-                <Tag value="Brain_int_Brain_cell" />
-                <Tag value="Neighborhood: Interstitial / Intracellular" />
-              </Tags>
-              <Children>
-                <Container id="NMCRpfugP0GH8WPiPFcZNg" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="54r_7LAw40-xmy3fXRNRSQ" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="xQZ40Mn0s0Wf7QlpiyG1_w" dim="Velocity" quantityType="0" />
-                    <Parameter id="I1MUpdukekekqulCbKH8qA" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="3-LEyoK2GEOuCEV2otw_AQ" dim="Velocity" quantityType="0" />
-                    <Parameter id="6j9FQHbg60uzqD9L6kqgLw" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="DIQILkkEz06QbATD24Bttw" dim="Flow (volume)" quantityType="0" />
-                    <Parameter id="lfLteiJgeEyKUs5yBpNFGg" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="GRkU-raPfUeXS_32oxTzjQ" dim="Flow (volume)" quantityType="0" />
-                    <Parameter id="AHQdoockzkyYJoVFp2B9ug" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="77y-acNA7Ey2TQxOY27MNQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="W4rrGWiCNE26GmyfRB9AwA" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="oN2ATzYjS0yX8ZVdOx27Cg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="zwu3KzZZ10mm6Rxkabm_0g" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" formula="zVyrXKuGrEuXiMr28hbOWw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="mxi80IHBoUeiIosaGAxgAQ" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" formula="3cJBFwQjyUqzb_kQadzpHA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="TIbOIcz3dEK6h9-SppkfbA" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" formula="RfYnbVhHTEGWbtOnyEv3YA" dim="Dimensionless" quantityType="0" />
-                    <Transport id="cUGBzJ8d6US8TNsp7LgCww" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Other" dimension="Dimensionless" formula="9g8IIGo9pUaEDIqMZyPvyg" sourceAmount="Sz0YCzmSPkGYP_QKdWyWcA" targetAmount="9ITwvCfw9kyjNoQJnFtNgw" />
-                  </Children>
-                </Container>
-                <Parameter id="9VOplDqg0EK4bozNqiUvKA" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" formula="9ol6cLXyckaP83cSsTs0-A" dim="Surface" quantityType="0" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="FHgRVDk79064JiruhHUnZA" name="Fat_pls_Fat_bc" description="Neighborhood between Fat/Plasma and Fat/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="0jH8wQWByEGQirnpU3MU9w" secondNeighbor="UCI13t7Y1UeZyAqMB-vPQA">
-              <Tags>
-                <Tag value="Fat_pls_Fat_bc" />
-                <Tag value="Neighborhood: Plasma / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="iRBnwl2gpkuIm7iS1quvnw" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Transport id="W0uPyjmbDk27X_nNk1pDrQ" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Other" dimension="Dimensionless" formula="q9WUByCy-USnNpE4rgFjmw" sourceAmount="I1lH2_D7D0yUrk6B1gdFsg" targetAmount="6Fgkh6wtHEKhlsf-k4BBww" />
-                  </Children>
-                </Container>
-                <Parameter id="qqTtPulNGEKq9qrKKTX1tQ" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" formula="knk97U-JXUyG3w3P4UBrkw" dim="Surface" quantityType="0" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="YBxjzboGokuVJZJOkGgiDA" name="Fat_bc_VenousBlood_bc" description="Neighborhood between Fat/Blood Cells and Venous Blood/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="UCI13t7Y1UeZyAqMB-vPQA" secondNeighbor="vv8rxyxvYkasBnpcCaOSyg">
-              <Tags>
-                <Tag value="Fat_bc_VenousBlood_bc" />
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="XpU1cduws0OkGK3fFVExLw" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Transport id="kaDaqomVq0KaI1AgghMOTA" name="MassTransferOrgRBC2BloodPool" description="Mass transfer from organ: Blood Cells to Arterial Blood: Blood Cells" mode="Logical" containerType="Other" dimension="Dimensionless" formula="1d9HTsKJDE-mGsiBJUjLXw" sourceAmount="6Fgkh6wtHEKhlsf-k4BBww" targetAmount="FMF6RMb5pkyvcn1PXHNkgw" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="5UFG3OZDJk-zhq8L_50o_w" name="Fat_int_Fat_cell" description="Neighborhood between Fat/Interstitial and Fat/Intracellular" mode="Logical" containerType="Other" firstNeighbor="i5oPN6d4TUivselGMRZdYg" secondNeighbor="NeQ8sho6_k-PDOwc7ryHyQ">
-              <Tags>
-                <Tag value="Fat_int_Fat_cell" />
-                <Tag value="Neighborhood: Interstitial / Intracellular" />
-              </Tags>
-              <Children>
-                <Container id="ICOcGvgyxE67NrVzKTMOFg" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="LXocmvFTsUGZTgKP9RoPbA" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="DIQILkkEz06QbATD24Bttw" dim="Flow (volume)" quantityType="0" />
-                    <Parameter id="fxUbD0OikU6sqh5i-9onWw" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="3-LEyoK2GEOuCEV2otw_AQ" dim="Velocity" quantityType="0" />
-                    <Parameter id="MOSZ2BJpFk2q_5v1ER3zwA" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="GRkU-raPfUeXS_32oxTzjQ" dim="Flow (volume)" quantityType="0" />
-                    <Parameter id="OIRMEPHhwkiOyFEUV4gKeA" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="a3AHAyhM206wB22qW3CJpQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="tOOesPb9V0mQ2E5TZWUO7w" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="cQVQIPdMD06RwRb1UOIXkg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="jCj2hqtMmUepyw7qLrCuSg" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" formula="17UJ5M_qeUq5qrgat0aX-w" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="fxGxJKOafkKCxYoQG5CUXA" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" formula="3cJBFwQjyUqzb_kQadzpHA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="kMkzZWcH4UKhvcoBiv66ig" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="xQZ40Mn0s0Wf7QlpiyG1_w" dim="Velocity" quantityType="0" />
-                    <Parameter id="28s_pCqX5U2Csbl5LkBpxw" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" formula="l2yC3XeiUUSeaR-cYrq2dg" dim="Dimensionless" quantityType="0" />
-                    <Transport id="uZKtV9B8xkuZLCj9v0xKGg" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Other" dimension="Dimensionless" formula="2DI9-saW9km9mpp8dFPbnA" sourceAmount="LmLInrymGUuN9qsvL0664g" targetAmount="whncayrIJ0OLCMz2NFh4Ug" />
-                  </Children>
-                </Container>
-                <Parameter id="lz-v7F-5ykWm_OawyiwNZw" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" formula="jXng_tH0QEup1vLSMbn1jg" dim="Surface" quantityType="0" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="siybtVvYgk6oOOR-zthHNg" name="Fat_pls_Fat_int" description="Neighborhood between Fat/Plasma and Fat/Interstitial" mode="Logical" containerType="Other" firstNeighbor="0jH8wQWByEGQirnpU3MU9w" secondNeighbor="i5oPN6d4TUivselGMRZdYg">
-              <Tags>
-                <Tag value="Fat_pls_Fat_int" />
-                <Tag value="Neighborhood: Plasma / Interstitial" />
-              </Tags>
-              <Children>
-                <Container id="wYsybK7Gk0yXXvWEajHn_g" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="h563vgJXRESzZKkajgADCQ" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" formula="-DEFSC4vn0ajeww6-OP5eg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="7G6_ckICn0iVSuumEiJAmw" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" formula="VXKcmSPTIE6Q66r1ZibQ-A" dim="Velocity" quantityType="0" />
-                    <Transport id="Il6CJuI36U6hwxqH4UraTA" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Other" dimension="Dimensionless" formula="Vti_KL7lAEKX-N3H7bhjlA" sourceAmount="I1lH2_D7D0yUrk6B1gdFsg" targetAmount="LmLInrymGUuN9qsvL0664g" />
-                  </Children>
-                </Container>
-                <Parameter id="UYGJLW_odUiCL-9Ty-uEBA" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" formula="jjP4lXCxgU2gowdv5WTwvQ" dim="Surface" quantityType="0" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="bJA9s7yYeUeE0_VZe0epnA" name="Fat_pls_VenousBlood_pls" description="Neighborhood between Fat/Plasma and Venous Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="0jH8wQWByEGQirnpU3MU9w" secondNeighbor="R5jgBt3okEeUHClw7hT2EA">
-              <Tags>
-                <Tag value="Fat_pls_VenousBlood_pls" />
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="STkCacP-FkWUSx96I38zKA" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Transport id="KVEQ0L-dZE2H_GwZSwIIng" name="MassTransferOrgPl2BloodPool" description="Mass transfer from organ: Plasma to Venous Blood: Plasma" mode="Logical" containerType="Other" dimension="Dimensionless" formula="7D_9J6H61E-1mosIEbT5aw" sourceAmount="I1lH2_D7D0yUrk6B1gdFsg" targetAmount="0z8uD-0gmE61mkI_fDKAZQ" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="bFnZuwxQn0uzvt3b8risNw" name="Gonads_bc_VenousBlood_bc" description="Neighborhood between Gonads/Blood Cells and Venous Blood/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="OgNkWaheck6JK2s9i6-9DQ" secondNeighbor="vv8rxyxvYkasBnpcCaOSyg">
-              <Tags>
-                <Tag value="Gonads_bc_VenousBlood_bc" />
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="5AtYQ29GIUWgTuU8ux65Eg" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Transport id="wepMtzfSd0qAxRLVU8we8A" name="MassTransferOrgRBC2BloodPool" description="Mass transfer from organ: Blood Cells to Arterial Blood: Blood Cells" mode="Logical" containerType="Other" dimension="Dimensionless" formula="QuZw0k24j0a4l9mhxrBEtw" sourceAmount="ePM3dZXuUEO7zYoYxZnSKw" targetAmount="FMF6RMb5pkyvcn1PXHNkgw" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="r_HmVZPAiU-yu7MagXNAow" name="Gonads_pls_VenousBlood_pls" description="Neighborhood between Gonads/Plasma and Venous Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="R2x32V7OFkCwNQ0G6YbIJQ" secondNeighbor="R5jgBt3okEeUHClw7hT2EA">
-              <Tags>
-                <Tag value="Gonads_pls_VenousBlood_pls" />
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="MT8Yq4ugWUyT4zQag9IP1g" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Transport id="RepCCtnzRECCAfx4SJM_DA" name="MassTransferOrgPl2BloodPool" description="Mass transfer from organ: Plasma to Venous Blood: Plasma" mode="Logical" containerType="Other" dimension="Dimensionless" formula="tpOiVDVC20iMtvq7qpY3QQ" sourceAmount="GcDRcaYXGkyq82AuLtfy_w" targetAmount="0z8uD-0gmE61mkI_fDKAZQ" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="LIWXgBuGr0i1d6vgZGrNnw" name="Gonads_int_Gonads_cell" description="Neighborhood between Gonads/Interstitial and Gonads/Intracellular" mode="Logical" containerType="Other" firstNeighbor="K9e2tlLKkUGe-jcP_xQN-w" secondNeighbor="zXzYT-bBkEmv1RPflRgipw">
-              <Tags>
-                <Tag value="Gonads_int_Gonads_cell" />
-                <Tag value="Neighborhood: Interstitial / Intracellular" />
-              </Tags>
-              <Children>
-                <Container id="z6acgBffPkSfKDD1UXJLHQ" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="5GV5F6AvBE23CkRsAJIIew" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="Zj9ByYfEK02YWn6gK1bv5w" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="uYxeemEbDkSCDz2ZhR8JNw" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="xQZ40Mn0s0Wf7QlpiyG1_w" dim="Velocity" quantityType="0" />
-                    <Parameter id="TFBG_2OGSk6FjK_UJvo2gw" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="3-LEyoK2GEOuCEV2otw_AQ" dim="Velocity" quantityType="0" />
-                    <Parameter id="hL9GiSlZt0iHN7mfFMd4Jw" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="DIQILkkEz06QbATD24Bttw" dim="Flow (volume)" quantityType="0" />
-                    <Parameter id="Ow2nez6cdEm8l49rXV6fAA" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="ZoEguNKKNEiDzQ3qtQSTCg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="WIFXWHplvUmq111vZjpgZQ" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" formula="GVfwx3p49kqz6s8jqWixsQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="qJ5Vtf0HqUqQtLQnHt5uaQ" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" formula="3cJBFwQjyUqzb_kQadzpHA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="pxXtZTJs1kGusMlnK0ot5g" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="GRkU-raPfUeXS_32oxTzjQ" dim="Flow (volume)" quantityType="0" />
-                    <Parameter id="ouEjPBnE1kGof2z6vF1TVg" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" formula="3l9asbpDiUCpbKgMU8YGbA" dim="Dimensionless" quantityType="0" />
-                    <Transport id="U35o09FCzEuc9615P-o2lQ" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Other" dimension="Dimensionless" formula="ukemqZCLd0a7Pp0nSrLTsA" sourceAmount="xiLkThQjwUizWoy8bV8TaQ" targetAmount="uCTVq09MzE6g1lasVCYgwg" />
-                  </Children>
-                </Container>
-                <Parameter id="m3-N0cKzPk-VkFi5iS5qdA" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" formula="6c19S03wIE2QRaB_IrS1pQ" dim="Surface" quantityType="0" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="d911dKEiPEqShj2TKgPaXA" name="Gonads_pls_Gonads_bc" description="Neighborhood between Gonads/Plasma and Gonads/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="R2x32V7OFkCwNQ0G6YbIJQ" secondNeighbor="OgNkWaheck6JK2s9i6-9DQ">
-              <Tags>
-                <Tag value="Gonads_pls_Gonads_bc" />
-                <Tag value="Neighborhood: Plasma / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="VTZ1dEtvOUeiuhrvu68b7A" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Transport id="yZuwcMiaIUivcI5jjqrY_A" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Other" dimension="Dimensionless" formula="BGG9JM59f0eB78S5cwuL8g" sourceAmount="GcDRcaYXGkyq82AuLtfy_w" targetAmount="ePM3dZXuUEO7zYoYxZnSKw" />
-                  </Children>
-                </Container>
-                <Parameter id="G3zMOPQU1kiWOSWNStqPeQ" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" formula="Wwv9mOPyVk-hF4mfHiCaQA" dim="Surface" quantityType="0" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="E6f10Z3bVEKUK5JEsylc7Q" name="Gonads_pls_Gonads_int" description="Neighborhood between Gonads/Plasma and Gonads/Interstitial" mode="Logical" containerType="Other" firstNeighbor="R2x32V7OFkCwNQ0G6YbIJQ" secondNeighbor="K9e2tlLKkUGe-jcP_xQN-w">
-              <Tags>
-                <Tag value="Gonads_pls_Gonads_int" />
-                <Tag value="Neighborhood: Plasma / Interstitial" />
-              </Tags>
-              <Children>
-                <Container id="D2AmN6Cp_EaV3fOmvyJDKQ" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="lKTLWqyPxkeyhRokC6SfuQ" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" formula="QFY7G2X3HkqoVjbVpAJT9g" dim="Velocity" quantityType="0" />
-                    <Parameter id="__o10A5SFUm2smWrVu0Daw" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" formula="-DEFSC4vn0ajeww6-OP5eg" dim="Dimensionless" quantityType="0" />
-                    <Transport id="Pojz9D2QCky8H1cpWhUTCg" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Other" dimension="Dimensionless" formula="5pcWsDEXTkCnKL1fPcra1g" sourceAmount="GcDRcaYXGkyq82AuLtfy_w" targetAmount="xiLkThQjwUizWoy8bV8TaQ" />
-                  </Children>
-                </Container>
-                <Parameter id="U9O_cZ-Gb0OVfJWF4OvPIw" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" formula="eTkh3nq8-kWUiYJ_1rhMDw" dim="Surface" quantityType="0" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="QLX9N5fX6EW8d22Pjob2Dw" name="Heart_pls_Heart_bc" description="Neighborhood between Heart/Plasma and Heart/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="CsSxO3lz80SgnIM_Zfz4QA" secondNeighbor="p5ZOEMF5SkKVwHS_PuCniQ">
-              <Tags>
-                <Tag value="Heart_pls_Heart_bc" />
-                <Tag value="Neighborhood: Plasma / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="dLm6fX1crU-6OapODt-LiQ" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Transport id="LfafHX4O4EGv6Gr6TgJmug" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Other" dimension="Dimensionless" formula="M2nHP0uSCE6bKGRcXHZgGA" sourceAmount="YMDdX25Q00mDUaG1pnvpJw" targetAmount="lwq80CvTqkiI-A7SBbmn6A" />
-                  </Children>
-                </Container>
-                <Parameter id="Mg1dFVLDG0OpXfGR2Zqi_Q" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" formula="gikbV-k4LE2YasS0SQAJQQ" dim="Surface" quantityType="0" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="owN32mO8YEGvSeVv7RC-Cg" name="Heart_pls_VenousBlood_pls" description="Neighborhood between Heart/Plasma and Venous Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="CsSxO3lz80SgnIM_Zfz4QA" secondNeighbor="R5jgBt3okEeUHClw7hT2EA">
-              <Tags>
-                <Tag value="Heart_pls_VenousBlood_pls" />
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="eixv94wTIES9jnv1OEc2Tw" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Transport id="CRLB8P5WAkGid85dPHr_fg" name="MassTransferOrgPl2BloodPool" description="Mass transfer from organ: Plasma to Venous Blood: Plasma" mode="Logical" containerType="Other" dimension="Dimensionless" formula="uFGm76m500i-S-gTLa08UA" sourceAmount="YMDdX25Q00mDUaG1pnvpJw" targetAmount="0z8uD-0gmE61mkI_fDKAZQ" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="T4uIRg8cJUa7_I6fPI982w" name="Heart_pls_Heart_int" description="Neighborhood between Heart/Plasma and Heart/Interstitial" mode="Logical" containerType="Other" firstNeighbor="CsSxO3lz80SgnIM_Zfz4QA" secondNeighbor="q3Q7c1P_CEKLIDr5kHaHHg">
-              <Tags>
-                <Tag value="Heart_pls_Heart_int" />
-                <Tag value="Neighborhood: Plasma / Interstitial" />
-              </Tags>
-              <Children>
-                <Container id="VCPi34IAj0qDlULi0DX9Wg" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="xufCVANOM0CvaTVgT4xVYQ" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" formula="O3A-V938nUWSKR6yAmzFKQ" dim="Velocity" quantityType="0" />
-                    <Parameter id="Mx--N3VWeU6yQqfq3LEVJw" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" formula="-DEFSC4vn0ajeww6-OP5eg" dim="Dimensionless" quantityType="0" />
-                    <Transport id="Q64vUVDkd0GJHVRjfdaOig" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Other" dimension="Dimensionless" formula="H0spfsRZ_U22dl9ItmNnYA" sourceAmount="YMDdX25Q00mDUaG1pnvpJw" targetAmount="VLWpXq_vMEiDU1SPWWDynQ" />
-                  </Children>
-                </Container>
-                <Parameter id="gdnTMkG490W9l75pp9otVw" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" formula="cjr7AyLR7EyIhbNMYv9uIA" dim="Surface" quantityType="0" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="SlskwARIhkavf0IEJridUQ" name="Heart_int_Heart_cell" description="Neighborhood between Heart/Interstitial and Heart/Intracellular" mode="Logical" containerType="Other" firstNeighbor="q3Q7c1P_CEKLIDr5kHaHHg" secondNeighbor="MNoimPFj90uqGm1i-9DAcA">
-              <Tags>
-                <Tag value="Heart_int_Heart_cell" />
-                <Tag value="Neighborhood: Interstitial / Intracellular" />
-              </Tags>
-              <Children>
-                <Container id="SAmmGvKLlEmw0nDLiM04mg" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="5m-9W0sCpkyTWTpXjA4Ghg" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" formula="3cJBFwQjyUqzb_kQadzpHA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="jpBLqCBeVU6E0MIlS65L4g" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="xQZ40Mn0s0Wf7QlpiyG1_w" dim="Velocity" quantityType="0" />
-                    <Parameter id="yJcosKNRAUqLJPcMUFXC-A" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="3-LEyoK2GEOuCEV2otw_AQ" dim="Velocity" quantityType="0" />
-                    <Parameter id="vlBrLH4Vc02tbZFGk1E7bw" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="DIQILkkEz06QbATD24Bttw" dim="Flow (volume)" quantityType="0" />
-                    <Parameter id="XSG7timlREyiTTrX7JWKqw" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="GRkU-raPfUeXS_32oxTzjQ" dim="Flow (volume)" quantityType="0" />
-                    <Parameter id="z6s82lNeikKugwoTtzTsOQ" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="_HLqFqxQr0KD-FeIQJXLMw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="go7rlU6oa0m3Tg8ashNpfQ" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" formula="fn-g9hq6SE-0MyI1xU2aFw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="c8oGjJTfa06gYvPFz8VnQw" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="F83qr9nnFE-AMHZ_rd3a3g" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="bIEOjqyv6UuNcij4nScHjQ" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" formula="QY_0OBZBhUmlSI4kZel2nA" dim="Dimensionless" quantityType="0" />
-                    <Transport id="hhvnHz6oZUyGMuimUwZ30g" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Other" dimension="Dimensionless" formula="kBTu1hb1REqWyQDvD4DXPg" sourceAmount="VLWpXq_vMEiDU1SPWWDynQ" targetAmount="6bkU3EYxG0ihpZMNf555hw" />
-                  </Children>
-                </Container>
-                <Parameter id="-h04NuGUF06d8lipi3xb4w" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" formula="rIhywZUnmEO73F42MIjigw" dim="Surface" quantityType="0" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="K6s8hhP64kOJ3Xc44RTflw" name="Heart_bc_VenousBlood_bc" description="Neighborhood between Heart/Blood Cells and Venous Blood/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="p5ZOEMF5SkKVwHS_PuCniQ" secondNeighbor="vv8rxyxvYkasBnpcCaOSyg">
-              <Tags>
-                <Tag value="Heart_bc_VenousBlood_bc" />
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="BzoHxWubqk6oaA1SgwU3aA" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Transport id="H2StfNAIDE29mf74R63zog" name="MassTransferOrgRBC2BloodPool" description="Mass transfer from organ: Blood Cells to Arterial Blood: Blood Cells" mode="Logical" containerType="Other" dimension="Dimensionless" formula="viFSVjp1-kCecxWudQQR4Q" sourceAmount="lwq80CvTqkiI-A7SBbmn6A" targetAmount="FMF6RMb5pkyvcn1PXHNkgw" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="uQRPUtjLIkaZAc5ixpSRhA" name="Kidney_bc_VenousBlood_bc" description="Neighborhood between Kidney/Blood Cells and Venous Blood/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="C7mUPb7PDkWnMGdSpKh67Q" secondNeighbor="vv8rxyxvYkasBnpcCaOSyg">
-              <Tags>
-                <Tag value="Kidney_bc_VenousBlood_bc" />
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="YfMsZ60JHkCCRfeST7qBdA" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Transport id="CnQbwEnr7k2ay6XG_MtXsg" name="MassTransferOrgRBC2BloodPool" description="Mass transfer from organ: Blood Cells to Arterial Blood: Blood Cells" mode="Logical" containerType="Other" dimension="Dimensionless" formula="aVHWWIU4xE6mWoBGq0g0EA" sourceAmount="hUEhZ6ECiEuzm7PPeH7rQw" targetAmount="FMF6RMb5pkyvcn1PXHNkgw" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="OiBLY2MPKE-shkgefe1gtA" name="Kidney_cell_Kidney_ur" description="Neighborhood between Kidney/Intracellular and Kidney/Urine" mode="Logical" containerType="Other" firstNeighbor="-gz0TSOaEEmu--WLnwn4cQ" secondNeighbor="spQGy125nkK-kkw11YRbaQ">
-              <Tags>
-                <Tag value="Kidney_cell_Kidney_ur" />
-                <Tag value="Neighborhood: Intracellular / Urine" />
-              </Tags>
-              <Children>
-                <Container id="rzBk306PckCk-0v3pIWdLg" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="5bBWYrUgYE-2HLF6lMnTcA" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" formula="bvbxxhxBq0aSQ5fMyBadQg" dim="Dimensionless" quantityType="0" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="avw2fh4YTkKAIKBTw-S4GA" name="Kidney_pls_Kidney_bc" description="Neighborhood between Kidney/Plasma and Kidney/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="plC6riLj_Uy-xFs0o2xqbQ" secondNeighbor="C7mUPb7PDkWnMGdSpKh67Q">
-              <Tags>
-                <Tag value="Kidney_pls_Kidney_bc" />
-                <Tag value="Neighborhood: Plasma / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="ianTPINMJUS5KqoJMXJpZQ" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Transport id="5iZQzKSFK0O8stmBNzikgQ" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Other" dimension="Dimensionless" formula="peP2_LcTkUqp3CS2hokMhg" sourceAmount="ldw3pQzm0EybvyXjw2rU6Q" targetAmount="hUEhZ6ECiEuzm7PPeH7rQw" />
-                  </Children>
-                </Container>
-                <Parameter id="NfciT6dYnUuMp5FiP7pRLQ" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" formula="yltJMUFhgUG8NQhXC-0IOg" dim="Surface" quantityType="0" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="mmvl_3ORx0ehsfzR7_dTSA" name="Kidney_pls_Kidney_int" description="Neighborhood between Kidney/Plasma and Kidney/Interstitial" mode="Logical" containerType="Other" firstNeighbor="plC6riLj_Uy-xFs0o2xqbQ" secondNeighbor="tOT926UGpEGOdbLuY_IdDw">
-              <Tags>
-                <Tag value="Kidney_pls_Kidney_int" />
-                <Tag value="Neighborhood: Plasma / Interstitial" />
-              </Tags>
-              <Children>
-                <Container id="2s15qreFHEaYe181VGnVZQ" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="XPJ0nilSXUG7-nrjeboj9Q" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" formula="LmVDr4BcO0CYe6Z2i_3Htg" dim="Velocity" quantityType="0" />
-                    <Parameter id="sihZmQLAxESvzV84_-8TqA" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" formula="-DEFSC4vn0ajeww6-OP5eg" dim="Dimensionless" quantityType="0" />
-                    <Transport id="u51VvzIl3kGebclPENVyxw" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Other" dimension="Dimensionless" formula="uhMA2cruskSBUik_ZJwkOA" sourceAmount="ldw3pQzm0EybvyXjw2rU6Q" targetAmount="uV34uosV_UCgDrF-8FzeHw" />
-                  </Children>
-                </Container>
-                <Parameter id="2AsS70wGmE2wxrTOSkRm0Q" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" formula="mflXKmDCekyZKDgoWfrSKw" dim="Surface" quantityType="0" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="4KXfZtClwUmrbBN6tqzgyg" name="Kidney_pls_Kidney_ur" description="Neighborhood between Kidney/Plasma and Kidney/Urine" mode="Logical" containerType="Other" firstNeighbor="plC6riLj_Uy-xFs0o2xqbQ" secondNeighbor="spQGy125nkK-kkw11YRbaQ">
-              <Tags>
-                <Tag value="Kidney_pls_Kidney_ur" />
-                <Tag value="Neighborhood: Plasma / Urine" />
-              </Tags>
-              <Children>
-                <Container id="55CRbc9wAkCobhOACoNuCw" name="Drug" mode="Logical" containerType="Other" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="gqkf4CSQOk6JZ8iEscmPmw" name="Kidney_pls_VenousBlood_pls" description="Neighborhood between Kidney/Plasma and Venous Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="plC6riLj_Uy-xFs0o2xqbQ" secondNeighbor="R5jgBt3okEeUHClw7hT2EA">
-              <Tags>
-                <Tag value="Kidney_pls_VenousBlood_pls" />
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="w6wWf6vNrk-oODqdK2KEkA" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Transport id="r8CewDri9E6RTRrWhxf9bg" name="MassTransferOrgPl2BloodPool" description="Mass transfer from organ: Plasma to Venous Blood: Plasma" mode="Logical" containerType="Other" dimension="Dimensionless" formula="P1v5xjD7dkCMkNczWpN28Q" sourceAmount="ldw3pQzm0EybvyXjw2rU6Q" targetAmount="0z8uD-0gmE61mkI_fDKAZQ" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="okNEokihWkacgJCSF_2ckQ" name="Kidney_int_Kidney_cell" description="Neighborhood between Kidney/Interstitial and Kidney/Intracellular" mode="Logical" containerType="Other" firstNeighbor="tOT926UGpEGOdbLuY_IdDw" secondNeighbor="-gz0TSOaEEmu--WLnwn4cQ">
-              <Tags>
-                <Tag value="Kidney_int_Kidney_cell" />
-                <Tag value="Neighborhood: Interstitial / Intracellular" />
-              </Tags>
-              <Children>
-                <Container id="CRmcmZUDmkuBiSf0MVir5w" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="-241MkhCRku3Dv1y7DNwUg" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="xQZ40Mn0s0Wf7QlpiyG1_w" dim="Velocity" quantityType="0" />
-                    <Parameter id="0ukxtnJWmUeL0wOXU00PUA" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="3-LEyoK2GEOuCEV2otw_AQ" dim="Velocity" quantityType="0" />
-                    <Parameter id="YfDFiZc0EUK664PtA5xlsw" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="DIQILkkEz06QbATD24Bttw" dim="Flow (volume)" quantityType="0" />
-                    <Parameter id="hrsC6NT9dkeiiXLr6OpTKA" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="GRkU-raPfUeXS_32oxTzjQ" dim="Flow (volume)" quantityType="0" />
-                    <Parameter id="otPF56C2k0SchoKg4xnH-g" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="RMzAG9Ou3UmVTtnPsFGugQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="h0WeazJlB0221akb2cTXtA" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="VIw7zKUa6EyR-e2X49o9mA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="W6OLW7rcrk2dtxKzDOOttg" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" formula="kfBcXT0-70W0cSuO8la5Uw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="lYr49nr9HUmDp5gYNTAc9A" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" formula="3cJBFwQjyUqzb_kQadzpHA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="QtHYEScHAESfMYHBiOc6vA" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" formula="ZuzdsOCsrUSOgMcr1e9CAQ" dim="Dimensionless" quantityType="0" />
-                    <Transport id="eYlqGxHCIEyBRYfNsrci6g" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Other" dimension="Dimensionless" formula="8Iy7DmF0QkyYNdodk9loKw" sourceAmount="uV34uosV_UCgDrF-8FzeHw" targetAmount="ij70h-BIA0m2f3cgt7nKFw" />
-                  </Children>
-                </Container>
-                <Parameter id="taY7_pKkTUq9eUpmAWzN0g" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" formula="jt7fZaeF-EGvnWFIcoHPyQ" dim="Surface" quantityType="0" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="0F9b1Jc-_U2DEQDfOGX_WA" name="Lumen_uje_UpperJejunum_cell" description="Neighborhood between Lumen/Upper Jejunum and Mucosa/Upper Jejunum/Intracellular" mode="Logical" containerType="Other" firstNeighbor="T_r3PYDtuUqoyydWMcZ6Ig" secondNeighbor="N3VDr-XRDkSr4mlVC2UkHQ">
-              <Tags>
-                <Tag value="Lumen_uje_UpperJejunum_cell" />
-                <Tag value="Neighborhood: UpperJejunum / Intracellular" />
-              </Tags>
-              <Children>
-                <Container id="eEHIgRifUkSaiLxNu8Px8g" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="9fQsCTAGJUio4hTmpr_IJQ" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="3uQ_8bks5kSiesc_SOfNwA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="cujjGtonWka7S-Qvp0mtGA" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="aJba9lRteUSyHr8r46GXyw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="BsZAVW6u80yjjhUp75IImg" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="Aw8vq5KCWEOCAoMQrVN6FQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="CyJq815hR0q6c3I332uXJQ" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="AAnDqAX9zUqoNDW37i4yBQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="1UtfpheDUEe1iyBHVea91w" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" formula="7YLM1tS0_UCpr3DYiX5MQg" dim="Rate" quantityType="0" />
-                    <Parameter id="6dUsbWwVXku8VAL1t1RxAg" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="RJRIddynfU-kStoSCNdNxQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="T_Ana-MGxkKzJbKDcSX5Qw" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="S5rOyojRIUmpgOV6TPakRQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="CPCEUOAHmUO4gtsglevGwQ" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" formula="m_uQp1YG4EuKnKoLmz1CIw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="MbE1j8aLH0W8ot5eCycYUA" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" formula="-JMvlxXG90iQJ5HE5Zcktw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="adJfP5lcF0KaFbmrPg6N2g" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="zx-8xc1czky80eoto4ngEw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="3u4EJ91B_UKpUKKY0sltTQ" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="LsrlvN1kzk-4m-6Fn4RZSg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="qhs2SVG8m0iALJqr2lYKCQ" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="ftydPCSZkEmXOltiuu-juA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="9bqvXPYefEC1kGC-e65JYA" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="S_qjrFFhlUei9mGuxmLKJg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="xXWGC0sXmEm6KG_tz5-vyA" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="k8hWpEIpF0KjTAC5NbdvbA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="M6sFlrFcSkiy2N9tCfe7Ig" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="WFbKuaD2_Uut_BXIFvFxpA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="vTQ9fGhxTEC035V0cWrBrw" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="SzK_8omVIE-vZmY_eihelA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="0TJZo0eXYEiJNycxAzLqZQ" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="QWN9mrAel0-mdjkWIwyAtw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="MezCdHgREkOFjf3tK8SFvw" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="F6FIReabwUqeLEL5fA8UaA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="oRR5lAo9u0iyjS5TXY5yHg" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="Kf9Bxa2_b0Geq1rJPr-UGQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="A-hTevDo6kCrmMXIJgh0IQ" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="AkRbpFWVBEe9u5MbHZxalg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="A6iKst5fDU6Qh53JDrro-g" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="PNdPmUn30kWtQyW1_2I6dA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="JcfXroPOIUqVHP21Nmy_cg" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="jHqMv0sKAEijzlHGLXlFbQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="NUE7pZcChkueIdO4cllDgQ" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="u5hHZWaTw0Ca6Pfjug_IBg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="fKOKw_G7cEOOKzMlnUBu7w" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="q3UCyneZi0CZtpN2SylR9A" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="muA6k5k0CkmaNDKEQKtQtA" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="aMN4XH4f10CaDLbJlRvOYg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="HfsDyyF5UkC3RVMdunNa_Q" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="PdH_puI8x0SM-tI3E7CmgQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="Vq2ca1Mg0kuh_79eZgT49Q" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="xM7lqQL_aEy-cELqFKBf3w" dim="Dimensionless" quantityType="0" />
-                    <Transport id="4XoPc31YNU6KMS3zdkwumQ" name="DrugAbsorption_trans" description="Drug absorption transcellular" mode="Logical" containerType="Other" dimension="Dimensionless" formula="ODSthQbrHkGmZMtmzDpNMQ" sourceAmount="sY_deNTPkU-udpyOezaONw" targetAmount="PHa0MNb1DUaXgdsbKCSSmQ" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="3gATyrz9HEO248DYFdWAVA" name="UpperJejunum_bc_PortalVein_bc" description="Neighborhood between Upper Jejunum/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="bkf1EKQC6UWHf1_K1uz-Hg" secondNeighbor="UsK_koflU0aP-ubDRlslJQ">
-              <Tags>
-                <Tag value="UpperJejunum_bc_PortalVein_bc" />
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="gkB0hgUN2kmL5XC9p8uS4A" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="7lH0IFKzWEOLmXM4rF_vBA" name="Mass transfer rate (mucosa to portal vein blood cells)" description="Mass transfer rate (mucosa to portal vein blood cells)" persistable="0" isFixedValue="0" formula="JS9yHh7Jtk62lfgVLWdojA" dim="Rate" quantityType="0" />
-                    <Transport id="yw_hFL-Ev0in8ApgpvFBjA" name="MassTransferMucosaToPveBC" description="Mass transfer from Mucosa:Blood Cells To Portal Vein: Blood Cells" mode="Logical" containerType="Other" dimension="Dimensionless" formula="oMbRuFN4EEuFOZtnxEyd7A" sourceAmount="9xjcN-quk0yrAPxO3xJMjA" targetAmount="F8UZepNEFEqiqDVPY4DDnA" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="RYeeYfXxpEKDnfR0Ob9X2w" name="UpperJejunum_pls_PortalVein_pls" description="Neighborhood between Upper Jejunum/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="qeqwoTSkakOVMFqQIp36Rw" secondNeighbor="t3RJcRrWZk6Yk-_IRw-vvA">
-              <Tags>
-                <Tag value="UpperJejunum_pls_PortalVein_pls" />
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="Mz03HsXqf0qjNqkpqJXtWQ" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="M6kIhpoH3k6lYLlMbngRow" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" persistable="0" isFixedValue="0" formula="DBwzCUYLYkmhnDZaG2h9Fw" dim="Rate" quantityType="0" />
-                    <Transport id="jBWQVj_M4Ue8nDQ41bPJjQ" name="MassTransferMucosaToPvePlasma" description="Mass transfer from Mucosa:Plasma To Portal Vein: Plasma" mode="Logical" containerType="Other" dimension="Dimensionless" formula="bhsbgR5Wi0OLnxNjqyG9GQ" sourceAmount="Cyoj-iIBBUK7nqW_avA9uw" targetAmount="3epVIeHC_0m65IYsJjSaDQ" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="mIpO1_3g9EmxdnvcKFpE0w" name="Lumen_uje_UpperJejunum_pls" description="Neighborhood between Lumen/Upper Jejunum and Mucosa/Upper Jejunum/Plasma" mode="Logical" containerType="Other" firstNeighbor="T_r3PYDtuUqoyydWMcZ6Ig" secondNeighbor="qeqwoTSkakOVMFqQIp36Rw">
-              <Tags>
-                <Tag value="Lumen_uje_UpperJejunum_pls" />
-                <Tag value="Neighborhood: UpperJejunum / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="c7h75m7wrk2ctVy84HhQLg" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="PpJntt0rYkSy9lSgp418jw" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" formula="VxoF9hMDFECxqjPJBKYlHg" dim="Rate" quantityType="0" />
-                    <Transport id="slUmH1DkWUeqMavXOyBJhA" name="DrugAbsorption_para" description="Drug absorption paracellular" mode="Logical" containerType="Other" dimension="Dimensionless" formula="3y9jrE_Q0E2_I4qEgVIt-g" sourceAmount="sY_deNTPkU-udpyOezaONw" targetAmount="Cyoj-iIBBUK7nqW_avA9uw" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="sif81w8u1UKlpFtSZ-gWYA" name="Lumen_lje_LowerJejunum_pls" description="Neighborhood between Lumen/Lower Jejunum and Mucosa/Lower Jejunum/Plasma" mode="Logical" containerType="Other" firstNeighbor="kIyZFLx3Zka2-n_FBxYOFw" secondNeighbor="4Q7zgvuqcE-QpUYXuYeQwA">
-              <Tags>
-                <Tag value="Lumen_lje_LowerJejunum_pls" />
-                <Tag value="Neighborhood: LowerJejunum / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="5F_dOQp2QEmrv6fxvV7EKQ" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="71kTjCrtHESXyJJBswa4CA" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" formula="hbV7Z-JU40K4bjElL5aoBQ" dim="Rate" quantityType="0" />
-                    <Transport id="Bxued6tVlkSxsYcF5QMLmA" name="DrugAbsorption_para" description="Drug absorption paracellular" mode="Logical" containerType="Other" dimension="Dimensionless" formula="yLGkGYvGZkafZ_mrOj4n2A" sourceAmount="sGszVTR3d0Wpec6uwVrB5Q" targetAmount="IBK3hooVzE2t9QgNnGZ_0w" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="Xo6P5Ep_DUihTvrPZETY9Q" name="Lumen_lje_LowerJejunum_cell" description="Neighborhood between Lumen/Lower Jejunum and Mucosa/Lower Jejunum/Intracellular" mode="Logical" containerType="Other" firstNeighbor="kIyZFLx3Zka2-n_FBxYOFw" secondNeighbor="5vmKOnRiF06lebQSRhQJOg">
-              <Tags>
-                <Tag value="Lumen_lje_LowerJejunum_cell" />
-                <Tag value="Neighborhood: LowerJejunum / Intracellular" />
-              </Tags>
-              <Children>
-                <Container id="4h9tVf22gUOVA8ZrGoPCAg" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="zjzWVECAJ0eLyENImf6uTQ" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="aJba9lRteUSyHr8r46GXyw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="zc2JrU7MKUmXJOeM5symRw" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="Kf9Bxa2_b0Geq1rJPr-UGQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="N3sGoBKMtEuVq_hyHZExFg" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="AkRbpFWVBEe9u5MbHZxalg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="i0HvNXQ660yirYEQL7scsA" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="APy_0Z-vy0iQTCXjM8EnWA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="nQlIPEpfMUiEX3mUe51MkA" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="HqEF0LgE2E2nASySaYKXRg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="Tt5SJfeKR0OHzwAP-AgTsg" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="MikRJct9jE-7bI0NvpOWOA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="an_1iWB940ygddiPytsoSw" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="q3UCyneZi0CZtpN2SylR9A" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="QS-IAGdNJ0yEZ5ds14xL9A" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="aMN4XH4f10CaDLbJlRvOYg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="g2FyRRQFY0SG-8CVAJ0cEw" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="PdH_puI8x0SM-tI3E7CmgQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="PrpBAnsigEORV_lqF5J3FA" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="Aw8vq5KCWEOCAoMQrVN6FQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="BzsexhBdNE-Rlb1zmPYmGw" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="SzK_8omVIE-vZmY_eihelA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="AS-fxwnv0UWV-HBKhB4hpQ" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="3uQ_8bks5kSiesc_SOfNwA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="jDZl_2Tvfk67Yt8ju3SCGg" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="k8hWpEIpF0KjTAC5NbdvbA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="Tzh1yjPTVEOt8nPO2cuw4w" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="AAnDqAX9zUqoNDW37i4yBQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="0Mak0P-RYkOmTrblUUXY4g" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="F6FIReabwUqeLEL5fA8UaA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="f0nzwX5y5E-i4xHvrPjg4Q" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="RJRIddynfU-kStoSCNdNxQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="E8BrqFzow0O0Mn7ENpu3VQ" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" formula="GUcte5s2QU29B3lYBZLd6A" dim="Rate" quantityType="0" />
-                    <Parameter id="FozzoUJ5ekiIlPCMwScUGg" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="S5rOyojRIUmpgOV6TPakRQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="7EEQ1rJqQ0KkrLVnPWaEDQ" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" formula="uIWF6arDvEumr0Ifj9IbAA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="4dHEfnipMkGVUFe7YYmKqQ" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" formula="RzWcC777DU6-I7L70DHx0A" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="QjNR_2GbVEqwQNfJYbf-vg" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="ZycyQz18Nk29MZ1PFtcG_w" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="4pbx3d4hk0eOVEdbatAIXA" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="cd2hChz-vk2epyez7kyceA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="xJIVP68hCUqnoLZGkNlZ1g" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="4P9QIdLgvUy5rCGmkGsk9g" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="kN8UTms92U-N0dcEcPTjig" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="S_qjrFFhlUei9mGuxmLKJg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="Z1AhvqOtdUaVzXw0pwqnyw" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="xM7lqQL_aEy-cELqFKBf3w" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="nTX5aSLvb0WDsfXpFZEh6Q" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="WFbKuaD2_Uut_BXIFvFxpA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="8zep0ieLOEyGdYFjJDRR1g" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="QWN9mrAel0-mdjkWIwyAtw" dim="Dimensionless" quantityType="0" />
-                    <Transport id="bK-l4MZZeEiz27lY_Epoeg" name="DrugAbsorption_trans" description="Drug absorption transcellular" mode="Logical" containerType="Other" dimension="Dimensionless" formula="yR0JvJxza0Ofobr75nldLg" sourceAmount="sGszVTR3d0Wpec6uwVrB5Q" targetAmount="WWPxNCTxFUiGAAGb_xVXCQ" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="HCxt_Nbdg0-lZLOcc-fgZw" name="LowerJejunum_pls_PortalVein_pls" description="Neighborhood between Lower Jejunum/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="4Q7zgvuqcE-QpUYXuYeQwA" secondNeighbor="t3RJcRrWZk6Yk-_IRw-vvA">
-              <Tags>
-                <Tag value="LowerJejunum_pls_PortalVein_pls" />
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="xXpsctWyVUuUz1MnYmzX0g" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="v-CjBxBP8E-N2lU1g7OS0A" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" persistable="0" isFixedValue="0" formula="wtUFrrDj1kOJzaOMwcdseg" dim="Rate" quantityType="0" />
-                    <Transport id="Dw3m0qkoJ0aUulA4ur0DAQ" name="MassTransferMucosaToPvePlasma" description="Mass transfer from Mucosa:Plasma To Portal Vein: Plasma" mode="Logical" containerType="Other" dimension="Dimensionless" formula="DMettJEP1k6Y-KuR1ka3aw" sourceAmount="IBK3hooVzE2t9QgNnGZ_0w" targetAmount="3epVIeHC_0m65IYsJjSaDQ" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="i4X9W9KIMkCHCFlapgCm0Q" name="LowerJejunum_bc_PortalVein_bc" description="Neighborhood between Lower Jejunum/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="MN94QcuVH0aTgduRFgCruw" secondNeighbor="UsK_koflU0aP-ubDRlslJQ">
-              <Tags>
-                <Tag value="LowerJejunum_bc_PortalVein_bc" />
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="Hv8c2Dps_Um6SiFDX5s36w" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="_fzhQgYCsESzqXUQb09cQg" name="Mass transfer rate (mucosa to portal vein blood cells)" description="Mass transfer rate (mucosa to portal vein blood cells)" persistable="0" isFixedValue="0" formula="Me7-CvAlz0ye7bSxaSvDSQ" dim="Rate" quantityType="0" />
-                    <Transport id="pMv4BNjAIUuZpcW-sw4j1w" name="MassTransferMucosaToPveBC" description="Mass transfer from Mucosa:Blood Cells To Portal Vein: Blood Cells" mode="Logical" containerType="Other" dimension="Dimensionless" formula="X-H7LDQAFk2st5DUERYr-g" sourceAmount="pkwIe2c8m0C2ShdFKX-RLw" targetAmount="F8UZepNEFEqiqDVPY4DDnA" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="4CCYyLIz_0O-x3lHkVZN6g" name="Lumen_coldesc_Lumen_colsigm" description="Neighborhood between Lumen/Colon Descendens and Lumen/Colon Sigmoid" mode="Logical" containerType="Other" firstNeighbor="9jArwMBpW06x34mUf4QukQ" secondNeighbor="t9buGgr6O02MMqVEqnLjgQ">
-              <Tags>
-                <Tag value="Lumen_coldesc_Lumen_colsigm" />
-                <Tag value="Neighborhood: ColonDescendens / ColonSigmoid" />
-              </Tags>
-              <Children>
-                <Container id="SToDX-yTO0Gm_QF50_GW5A" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Transport id="VcOfNlC32E6IR81HwoadVw" name="LumenDrugTransport_colsigm" description="Lumen drug transport from Colon Descendens to Colon Sigmoid" mode="Logical" containerType="Other" dimension="Dimensionless" formula="hQXNEcG6SUq7E10rdX_ccg" sourceAmount="NcJB6NUxaEGwgdsFjtyx4w" targetAmount="zyEivk-9f02yySFoyDYMYQ" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="t-Ep6c-vfU6RpslZ1JfVFg" name="Lumen_sto_Lumen_duo" description="Neighborhood between Lumen/Stomach and Lumen/Duodenum" mode="Logical" containerType="Other" firstNeighbor="dCtqsinD-EmmzbRUUa2_NQ" secondNeighbor="lZLwaVLayEa1f_nNQ00DVQ">
-              <Tags>
-                <Tag value="Lumen_sto_Lumen_duo" />
-                <Tag value="Neighborhood: Stomach / Duodenum" />
-              </Tags>
-              <Children>
-                <Container id="_DL7FSp0A0q06sVwtEEW6A" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="aDBiXtg9ek6A84G_dTaWRw" name="Oral mass absorbed" description="Oral mass absorbed from Lumen into mucosa" persistable="0" isFixedValue="0" formula="ea3Xgee3mUC8hkWv8LmAxA" dim="Amount" quantityType="0" rHSFormula="2M0fjSMl7UGfC2zkXmxtFw" />
-                    <Transport id="5BkcA2HEJ0eS9NJG3P9_RQ" name="LumenDrugTransport_duo" description="Lumen drug transport from Stomach to Duodenum" mode="Logical" containerType="Other" dimension="Dimensionless" formula="tTJb-cmnEUCVfwDHQqu0hg" sourceAmount="CzE8be5tsEWm86tdh6X94Q" targetAmount="Cp9CcV7Ov06YVtSbGuudTw" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="c1fYOPyBkUqwKyeoJ6yNZQ" name="Lumen_uje_Lumen_lje" description="Neighborhood between Lumen/Upper Jejunum and Lumen/Lower Jejunum" mode="Logical" containerType="Other" firstNeighbor="T_r3PYDtuUqoyydWMcZ6Ig" secondNeighbor="kIyZFLx3Zka2-n_FBxYOFw">
-              <Tags>
-                <Tag value="Lumen_uje_Lumen_lje" />
-                <Tag value="Neighborhood: UpperJejunum / LowerJejunum" />
-              </Tags>
-              <Children>
-                <Container id="V2HCgKH44U6TtsIjurJ1BQ" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Transport id="h2VE3y9Kk0qNl4uHJzYbYw" name="LumenDrugTransport_lje" description="Lumen drug transport from Upper Jejunum to Lower Jejunum" mode="Logical" containerType="Other" dimension="Dimensionless" formula="WjoxE5xxHEODx_X9IeOMrw" sourceAmount="sY_deNTPkU-udpyOezaONw" targetAmount="sGszVTR3d0Wpec6uwVrB5Q" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="mFEolYY7nU2sdam3WTSyqA" name="Lumen_uil_Lumen_lil" description="Neighborhood between Lumen/Upper Ileum and Lumen/Lower Ileum" mode="Logical" containerType="Other" firstNeighbor="zkRRnNgDBEmC3Btt-NZx3g" secondNeighbor="Lk6M-N8TdEOKfd5gHwDSMQ">
-              <Tags>
-                <Tag value="Lumen_uil_Lumen_lil" />
-                <Tag value="Neighborhood: UpperIleum / LowerIleum" />
-              </Tags>
-              <Children>
-                <Container id="eBPNFIfvr06t-JLxBaWWaw" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Transport id="0p4n7gWdr0mnPpImBEn6EQ" name="LumenDrugTransport_lil" description="Lumen drug transport from Upper Ileum to Lower Ileum" mode="Logical" containerType="Other" dimension="Dimensionless" formula="M1yc2NrEykq2cukB0xkNLA" sourceAmount="zyfJQqKwG0qIQhif8G_fgg" targetAmount="2rK9g1SMCEOsiulUb04Htg" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="tmyIY3OdRkud4fpC5qFTCQ" name="Lumen_lil_Lumen_cae" description="Neighborhood between Lumen/Lower Ileum and Lumen/Cecum" mode="Logical" containerType="Other" firstNeighbor="Lk6M-N8TdEOKfd5gHwDSMQ" secondNeighbor="hnrXLSFg2E-aaJshK4BODA">
-              <Tags>
-                <Tag value="Lumen_lil_Lumen_cae" />
-                <Tag value="Neighborhood: LowerIleum / Caecum" />
-              </Tags>
-              <Children>
-                <Container id="4PCZdHlUnUq0C5-WxVZgEg" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Transport id="d8-ii6d_nEqvxIinpte1Aw" name="LumenDrugTransport_cae" description="Lumen drug transport from Lower Ileum to Cecum" mode="Logical" containerType="Other" dimension="Dimensionless" formula="CrtyDlPH7EqCMZ3jirEnpQ" sourceAmount="2rK9g1SMCEOsiulUb04Htg" targetAmount="MnNILc-ThEuWb2MmUdz8QQ" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="o4gSoEJ8FUmdGY80RaVtYQ" name="Lumen_cae_Lumen_colasc" description="Neighborhood between Lumen/Cecum and Lumen/Colon Ascendens" mode="Logical" containerType="Other" firstNeighbor="hnrXLSFg2E-aaJshK4BODA" secondNeighbor="zUyNSXS6uEitLMuf2-ef3Q">
-              <Tags>
-                <Tag value="Lumen_cae_Lumen_colasc" />
-                <Tag value="Neighborhood: Caecum / ColonAscendens" />
-              </Tags>
-              <Children>
-                <Container id="MY7qncVGEkyjq3m54rRinA" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Transport id="neGgKLtKVkC914onrrzUww" name="LumenDrugTransport_colasc" description="Lumen drug transport from Cecum to Colon Ascendens" mode="Logical" containerType="Other" dimension="Dimensionless" formula="9wPz0ieyHky4SB88myYfjQ" sourceAmount="MnNILc-ThEuWb2MmUdz8QQ" targetAmount="jyt3cPowb0KjcfkF_O9aLA" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="VXC73KGgAU6l0EpgC1wZqg" name="Lumen_colasc_Lumen_coltrans" description="Neighborhood between Lumen/Colon Ascendens and Lumen/Colon Transversum" mode="Logical" containerType="Other" firstNeighbor="zUyNSXS6uEitLMuf2-ef3Q" secondNeighbor="Rs3PRJYB9UKcgdddhyZaZg">
-              <Tags>
-                <Tag value="Lumen_colasc_Lumen_coltrans" />
-                <Tag value="Neighborhood: ColonAscendens / ColonTransversum" />
-              </Tags>
-              <Children>
-                <Container id="0B-rmvqw2kmYI3lab9vbPg" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Transport id="CnVAjdPenkuJ3Q4QPzmYGA" name="LumenDrugTransport_coltrans" description="Lumen drug transport from Colon Ascendens to Colon Transversum" mode="Logical" containerType="Other" dimension="Dimensionless" formula="QvWAaGEv3kKfNeFdwPg47g" sourceAmount="jyt3cPowb0KjcfkF_O9aLA" targetAmount="bRBIqa0pgkWCj0_OcRNkPA" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="NZGfUHSQokCWbGq2Luw0tQ" name="Lumen_coltrans_Lumen_coldesc" description="Neighborhood between Lumen/Colon Transversum and Lumen/Colon Descendens" mode="Logical" containerType="Other" firstNeighbor="Rs3PRJYB9UKcgdddhyZaZg" secondNeighbor="9jArwMBpW06x34mUf4QukQ">
-              <Tags>
-                <Tag value="Lumen_coltrans_Lumen_coldesc" />
-                <Tag value="Neighborhood: ColonTransversum / ColonDescendens" />
-              </Tags>
-              <Children>
-                <Container id="l3AUvZJFCkKN5ww61oVgLg" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Transport id="jUowGmyic0-id-r3LdHuqA" name="LumenDrugTransport_coldesc" description="Lumen drug transport from Colon Transversum to Colon Descendens" mode="Logical" containerType="Other" dimension="Dimensionless" formula="JMSUzeKl-UuO19hvlpOWWQ" sourceAmount="bRBIqa0pgkWCj0_OcRNkPA" targetAmount="NcJB6NUxaEGwgdsFjtyx4w" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="ncurDNuPSkm1pGRhmXGHkA" name="Lumen_lje_Lumen_uil" description="Neighborhood between Lumen/Lower Jejunum and Lumen/Upper Ileum" mode="Logical" containerType="Other" firstNeighbor="kIyZFLx3Zka2-n_FBxYOFw" secondNeighbor="zkRRnNgDBEmC3Btt-NZx3g">
-              <Tags>
-                <Tag value="Lumen_lje_Lumen_uil" />
-                <Tag value="Neighborhood: LowerJejunum / UpperIleum" />
-              </Tags>
-              <Children>
-                <Container id="uVoPemiFQkS6abKwmJeGJw" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Transport id="gRBS_sEsr0icn43TneaXIg" name="LumenDrugTransport_uil" description="Lumen drug transport from Lower Jejunum to Upper Ileum" mode="Logical" containerType="Other" dimension="Dimensionless" formula="BqYcqrvsTkmMmr4C4qzdYQ" sourceAmount="sGszVTR3d0Wpec6uwVrB5Q" targetAmount="zyfJQqKwG0qIQhif8G_fgg" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="kHaKYwvaAEey6N2603nuIA" name="Lumen_duo_Lumen_uje" description="Neighborhood between Lumen/Duodenum and Lumen/Upper Jejunum" mode="Logical" containerType="Other" firstNeighbor="lZLwaVLayEa1f_nNQ00DVQ" secondNeighbor="T_r3PYDtuUqoyydWMcZ6Ig">
-              <Tags>
-                <Tag value="Lumen_duo_Lumen_uje" />
-                <Tag value="Neighborhood: Duodenum / UpperJejunum" />
-              </Tags>
-              <Children>
-                <Container id="61zRiE3N20OP0QZDTjxlRQ" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Transport id="TLExErrniEOYHgYld9D0HA" name="LumenDrugTransport_uje" description="Lumen drug transport from Duodenum to Upper Jejunum" mode="Logical" containerType="Other" dimension="Dimensionless" formula="sx8O2cEG5EqydDq6KwDLuQ" sourceAmount="Cp9CcV7Ov06YVtSbGuudTw" targetAmount="sY_deNTPkU-udpyOezaONw" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="ESjqCi-LKkOhxHDFPE8ruQ" name="Lumen_colsigm_Lumen_rect" description="Neighborhood between Lumen/Colon Sigmoid and Lumen/Rectum" mode="Logical" containerType="Other" firstNeighbor="t9buGgr6O02MMqVEqnLjgQ" secondNeighbor="OMeI603lPki93VUfJyqQow">
-              <Tags>
-                <Tag value="Lumen_colsigm_Lumen_rect" />
-                <Tag value="Neighborhood: ColonSigmoid / Rectum" />
-              </Tags>
-              <Children>
-                <Container id="aWRFC30LL0mxvNzhe-1vnA" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Transport id="pyPiLyVsFEK3g__rI4xp6A" name="LumenDrugTransport_rect" description="Lumen drug transport from Colon Sigmoid to Rectum" mode="Logical" containerType="Other" dimension="Dimensionless" formula="z6wEM7Qz3Emt4sWjsqIBkg" sourceAmount="zyEivk-9f02yySFoyDYMYQ" targetAmount="2jgxGdCNzUeUlFBm086prw" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="FAc-L_Xnrkaf8kOAHIGhiA" name="Lumen_rect_Lumen_fec" description="Neighborhood between Lumen/Rectum and Lumen/Feces" mode="Logical" containerType="Other" firstNeighbor="OMeI603lPki93VUfJyqQow" secondNeighbor="Zb000C93tkOQsbWGbFP-_w">
-              <Tags>
-                <Tag value="Lumen_rect_Lumen_fec" />
-                <Tag value="Neighborhood: Rectum / Feces" />
-              </Tags>
-              <Children>
-                <Container id="uKCZlWlYEE68JkAXRgOjHQ" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Transport id="hLH7BJU_f02nj3P-vtkKDA" name="LumenDrugTransport_fec" description="Lumen drug transport from Rectum to Feces" mode="Logical" containerType="Other" dimension="Dimensionless" formula="sjAyecDLXkuvmqB4NM_5Ew" sourceAmount="2jgxGdCNzUeUlFBm086prw" targetAmount="aSxEuZbc3kiOJhMGmIHJUQ" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="YTUxFFIknEi9up34T1WxQQ" name="Stomach_int_Stomach_cell" description="Neighborhood between Stomach/Interstitial and Stomach/Intracellular" mode="Logical" containerType="Other" firstNeighbor="dsM-eBic2EiX35Jw6MAWJQ" secondNeighbor="4zjuWX0sR0eCa5Fxtr1w2g">
-              <Tags>
-                <Tag value="Stomach_int_Stomach_cell" />
-                <Tag value="Neighborhood: Interstitial / Intracellular" />
-              </Tags>
-              <Children>
-                <Container id="SRp0g-9DQ0isE8KeNbhn8g" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="FrwITFPTGkC5TYGxCDX54w" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="Q8oIB2_wM0CBmdPWAtxJMQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="0wOq23-cH0-9qpQPIlL86w" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="xQZ40Mn0s0Wf7QlpiyG1_w" dim="Velocity" quantityType="0" />
-                    <Parameter id="hgFmMCHvk0amxJM0V-Mpgg" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="3-LEyoK2GEOuCEV2otw_AQ" dim="Velocity" quantityType="0" />
-                    <Parameter id="MFbyJUPViEGiC_Hsoi3Thg" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="GRkU-raPfUeXS_32oxTzjQ" dim="Flow (volume)" quantityType="0" />
-                    <Parameter id="fJ7iU3l3DEydJmRcnCTH-w" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="DqO6CW_1GEi23v5KMvgZiw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="PdpI1xwq8UKcJALawjAwhg" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" formula="2u-nGwkouEeI_aVIML3ZZw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="ZkiVXFTXOki7hNenwSz_nQ" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" formula="3cJBFwQjyUqzb_kQadzpHA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="Y1fxgxT4uUiQiU3i4gUxNQ" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="DIQILkkEz06QbATD24Bttw" dim="Flow (volume)" quantityType="0" />
-                    <Parameter id="ugDSjK4InEqFLKTolMWTpA" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" formula="-lAAIA3mU0CtcR67BNBY5w" dim="Dimensionless" quantityType="0" />
-                    <Transport id="WnA6qb95EUql7zBTLc7FYw" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Other" dimension="Dimensionless" formula="71awQNunDU2TqGjCms-j9Q" sourceAmount="yw8Zl0mYSk-wXOPqkEExpA" targetAmount="XEssCflDyEOpsFc7tNK4OQ" />
-                  </Children>
-                </Container>
-                <Parameter id="7Vk479Bz6k6SnHJ8vp3XfA" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" formula="iIJrRAv5gkOdYktLSSxqIA" dim="Surface" quantityType="0" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="-b-UYa8QSU2g2aDQkRynxg" name="Stomach_pls_PortalVein_pls" description="Neighborhood between Stomach/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="j-2k7VES9ka5euMEPF9T8w" secondNeighbor="t3RJcRrWZk6Yk-_IRw-vvA">
-              <Tags>
-                <Tag value="Stomach_pls_PortalVein_pls" />
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="YXeLPdqsTk-Cc34c78byPg" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Transport id="GfCy868dOkOEk0pfHARycg" name="MassTransferOrgPl2BloodPool_pve" description="Mass transfer from organ: Plasma to Portal Vein: Plasma" mode="Logical" containerType="Other" dimension="Dimensionless" formula="Xpac5JdXO0K9vxpV-qTPVw" sourceAmount="kKt46BLgxk2cFdLr4ynp5g" targetAmount="3epVIeHC_0m65IYsJjSaDQ" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="mi53uvuj0Eu-LAo-s_gIYg" name="Stomach_bc_PortalVein_bc" description="Neighborhood between Stomach/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="bHoVLvrvKUOmXQKR7iPaJg" secondNeighbor="UsK_koflU0aP-ubDRlslJQ">
-              <Tags>
-                <Tag value="Stomach_bc_PortalVein_bc" />
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="VX3ssds6Lk2xmKFnKSliSw" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Transport id="CmsbaZ2cUUaJVh3jTfybew" name="MassTransferOrgRBC2BloodPool_Pve" description="Mass transfer from organ: Blood Cells to Portal Vein: Blood Cells" mode="Logical" containerType="Other" dimension="Dimensionless" formula="Fprgyxrz1kKSA59PleOlBQ" sourceAmount="B5S9SFj4f02rIOWx3cl5jA" targetAmount="F8UZepNEFEqiqDVPY4DDnA" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="AF7WdHnWkEOzCMOYFAmKdA" name="Stomach_pls_Stomach_int" description="Neighborhood between Stomach/Plasma and Stomach/Interstitial" mode="Logical" containerType="Other" firstNeighbor="j-2k7VES9ka5euMEPF9T8w" secondNeighbor="dsM-eBic2EiX35Jw6MAWJQ">
-              <Tags>
-                <Tag value="Stomach_pls_Stomach_int" />
-                <Tag value="Neighborhood: Plasma / Interstitial" />
-              </Tags>
-              <Children>
-                <Container id="2oiC4DAhOkaBlxoIkgxtvg" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="9jVnoKvg5UGi42WU72hDZQ" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" formula="s4ixGM0Ig0S-R0vidsO2Zw" dim="Velocity" quantityType="0" />
-                    <Parameter id="vJaC4bXQHEmA31yXo7aJkQ" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" formula="-DEFSC4vn0ajeww6-OP5eg" dim="Dimensionless" quantityType="0" />
-                    <Transport id="D607aNjg0U2wh89Yhpda7w" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Other" dimension="Dimensionless" formula="NoEZb2YZs0-XWurQ0krO6w" sourceAmount="kKt46BLgxk2cFdLr4ynp5g" targetAmount="yw8Zl0mYSk-wXOPqkEExpA" />
-                  </Children>
-                </Container>
-                <Parameter id="oaNiEQUtt0Ck2BEfs0wtYg" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" formula="NGIEMUMH40i1JeK30Q_ioA" dim="Surface" quantityType="0" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="Q66xVeKCZ0eBaxNF-eAvzw" name="Stomach_pls_Stomach_bc" description="Neighborhood between Stomach/Plasma and Stomach/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="j-2k7VES9ka5euMEPF9T8w" secondNeighbor="bHoVLvrvKUOmXQKR7iPaJg">
-              <Tags>
-                <Tag value="Stomach_pls_Stomach_bc" />
-                <Tag value="Neighborhood: Plasma / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="IufdsT8fZESiH0yJU8eQGQ" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Transport id="Z5ZngRPPA0ek6YkQAJq-2w" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Other" dimension="Dimensionless" formula="zX0hF2BQEku9vjmLnLpirA" sourceAmount="kKt46BLgxk2cFdLr4ynp5g" targetAmount="B5S9SFj4f02rIOWx3cl5jA" />
-                  </Children>
-                </Container>
-                <Parameter id="KghlMqamnkm13-MvbdjKXg" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" formula="VsGrm_ZeJUaqRIngsmrcbQ" dim="Surface" quantityType="0" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="hoRetnHa_EqFGRf1ioVkVg" name="Lumen_uil_UpperIleum_pls" description="Neighborhood between Lumen/Upper Ileum and Mucosa/Upper Ileum/Plasma" mode="Logical" containerType="Other" firstNeighbor="zkRRnNgDBEmC3Btt-NZx3g" secondNeighbor="eqxADnXJ7U-yx7RZ9RRnGQ">
-              <Tags>
-                <Tag value="Lumen_uil_UpperIleum_pls" />
-                <Tag value="Neighborhood: UpperIleum / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="pbAy2kIQrk2R6nkZxqcljw" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="GiIaxK8u4Uil4tYxAU0CgQ" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" formula="KLCoxzTJ4EGbuR_dFBPQ_Q" dim="Rate" quantityType="0" />
-                    <Transport id="iwLstX_s-kCcKzmaGWTFmA" name="DrugAbsorption_para" description="Drug absorption paracellular" mode="Logical" containerType="Other" dimension="Dimensionless" formula="tDINCj2pmU69v-QiZy2Dvg" sourceAmount="zyfJQqKwG0qIQhif8G_fgg" targetAmount="3LnxhiZCq0-_1-jmaYhb8w" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="UDMRhRSJUkynjR5MdoYofQ" name="Lumen_uil_UpperIleum_cell" description="Neighborhood between Lumen/Upper Ileum and Mucosa/Upper Ileum/Intracellular" mode="Logical" containerType="Other" firstNeighbor="zkRRnNgDBEmC3Btt-NZx3g" secondNeighbor="gBiM91b0lEOFJj41Hgmg7Q">
-              <Tags>
-                <Tag value="Lumen_uil_UpperIleum_cell" />
-                <Tag value="Neighborhood: UpperIleum / Intracellular" />
-              </Tags>
-              <Children>
-                <Container id="fB1HEyUtmUalWbmhcBPFSA" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="jdOJBD8CCU2likGBaka--g" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="AkRbpFWVBEe9u5MbHZxalg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="eouxeiFBBUOvU-jkpSD4FA" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="aJba9lRteUSyHr8r46GXyw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="FTQLnHhF4UeJRhmhVDho9w" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" formula="vzQ5MEryIUKtpUuuVQxD-g" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="7WmGcyMOcUSXSDbDnNSnsA" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="FdkcEegZpkCyGooWdWwgRA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="F_JWzS5nJkWQbq7xjovGhw" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="ciNKNKQZDEKrkSWF4pHueA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="KZi8PF0ZrUurZTZ-0YhQ6w" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="VPM6gMCmS0S54iBW7dqNpQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="tUCsOENdZkiDow0vmWW_HQ" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="S_qjrFFhlUei9mGuxmLKJg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="510wdn9MyUW4zgPfKe-Tsw" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="xM7lqQL_aEy-cELqFKBf3w" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="iyv6crnkKkaTvW61eohxow" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="WFbKuaD2_Uut_BXIFvFxpA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="dlTLQbzcOk-2XA5g7bDNbA" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="AAnDqAX9zUqoNDW37i4yBQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="EAHZKIyQf0i0qKw5DPMOcA" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="QWN9mrAel0-mdjkWIwyAtw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="owGZSakiBUmBnKv-JHVPiw" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="S5rOyojRIUmpgOV6TPakRQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="8JIVmsqkTk2CQJvC85YniQ" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="Kf9Bxa2_b0Geq1rJPr-UGQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="yW0-1StJrkSQs3ntCPtS0g" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="RJRIddynfU-kStoSCNdNxQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="voQtK7xJHkaBtxPe9QMwUQ" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="h-IikbIXa0mQ-9iq-Yj8rw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="c4FpzqezEUiqup3aPZmi2g" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="0ZRu8_moJ0e-qEavtdPdQA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="sAJT02mYSUKObVQrTsP79w" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="012y2BW0T0yhpG3gNWcBhg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="1wLmDb-qjUuLv_e4h3xeMg" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="q3UCyneZi0CZtpN2SylR9A" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="HMuUXnoeO0GszpHcjgG23Q" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="aMN4XH4f10CaDLbJlRvOYg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="GevLyXn33kqFy31b_-8q6Q" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="PdH_puI8x0SM-tI3E7CmgQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="JY208nUB5E6BleKyPXRA3g" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="Aw8vq5KCWEOCAoMQrVN6FQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="wfyXneRuEkyTxrFKXePBqw" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="SzK_8omVIE-vZmY_eihelA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="Xv5XzxyS0kCHZ2xGsEL1nQ" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="k8hWpEIpF0KjTAC5NbdvbA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="61S0VYg29EKNkiHMMFAWsg" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="F6FIReabwUqeLEL5fA8UaA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="LmC4ZfjDoEWA9l81MTuW6Q" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" formula="5dINMRIuHUmuMD0Kus-Slw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="yirXCnR07kO3rhQaogn5Ng" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" formula="UCPI7QnmZEWnSWoeIF7siQ" dim="Rate" quantityType="0" />
-                    <Parameter id="UzZzjJ1NjE6fnxWSPt-sGA" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="3uQ_8bks5kSiesc_SOfNwA" dim="Dimensionless" quantityType="0" />
-                    <Transport id="gXvAGqKbVkSzCnf3jra-mg" name="DrugAbsorption_trans" description="Drug absorption transcellular" mode="Logical" containerType="Other" dimension="Dimensionless" formula="PqfLEbRtPUeg6ds2YJL0-Q" sourceAmount="zyfJQqKwG0qIQhif8G_fgg" targetAmount="mGYOXZMgJUGhksXmlLzipQ" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="3Ok6TFaI4kinu3XIg6mYgw" name="UpperIleum_pls_PortalVein_pls" description="Neighborhood between Upper Ileum/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="eqxADnXJ7U-yx7RZ9RRnGQ" secondNeighbor="t3RJcRrWZk6Yk-_IRw-vvA">
-              <Tags>
-                <Tag value="UpperIleum_pls_PortalVein_pls" />
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="Dec-U3Nh40-ssU5rqxgclQ" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="zdM-wpIxG06VaLvRta8T1Q" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" persistable="0" isFixedValue="0" formula="cxGxgyxwFU2eXwSFlPelwg" dim="Rate" quantityType="0" />
-                    <Transport id="bxhGA7QdE029ARsvqtm_dA" name="MassTransferMucosaToPvePlasma" description="Mass transfer from Mucosa:Plasma To Portal Vein: Plasma" mode="Logical" containerType="Other" dimension="Dimensionless" formula="ZDbJZOer402Hw4-bZzyXhw" sourceAmount="3LnxhiZCq0-_1-jmaYhb8w" targetAmount="3epVIeHC_0m65IYsJjSaDQ" />
-                  </Children>
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-            <Neighborhood id="BSpoCneXG0a5ZVCVrXnOpA" name="UpperIleum_bc_PortalVein_bc" description="Neighborhood between Upper Ileum/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="O523UhgKSkeprp67LMaDag" secondNeighbor="UsK_koflU0aP-ubDRlslJQ">
-              <Tags>
-                <Tag value="UpperIleum_bc_PortalVein_bc" />
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="R6ebIS0pIUWg4EvRTaWGXw" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="Q10SHJIK3kiO_7uN5yTH4A" name="Mass transfer rate (mucosa to portal vein blood cells)" description="Mass transfer rate (mucosa to portal vein blood cells)" persistable="0" isFixedValue="0" formula="06jZR7k0GUCfMVFNvy3eag" dim="Rate" quantityType="0" />
-                    <Transport id="bV7KIRT5_UuoFo0q3jg0Iw" name="MassTransferMucosaToPveBC" description="Mass transfer from Mucosa:Blood Cells To Portal Vein: Blood Cells" mode="Logical" containerType="Other" dimension="Dimensionless" formula="Lq4LbdklDUeaIJ3WF-8UEw" sourceAmount="W8KLhlsWkU6-nxbVlLgfDA" targetAmount="F8UZepNEFEqiqDVPY4DDnA" />
-                  </Children>
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-            </Neighborhood>
-            <Neighborhood id="Am5qlSzYGEiBsZvU6hZaqg" name="SmallIntestine_pls_SmallIntestine_bc" description="Neighborhood between Small Intestine/Plasma and Small Intestine/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="_l2zQZC3T0igTnQWgWvr8Q" secondNeighbor="5Ye_xsRvs0WtJRsgL0Pz9w">
-              <Tags>
-                <Tag value="SmallIntestine_pls_SmallIntestine_bc" />
-                <Tag value="Neighborhood: Plasma / BloodCells" />
-                <Tag value="Small intestine  neighborhood" />
-              </Tags>
-              <Children>
-                <Container id="cXF1vmWgoUWazNiZrMRd5A" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Transport id="AXwMneyTsEKzQFjS24bEcA" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Other" dimension="Dimensionless" formula="wgfCc6Isjk2A9yTDZfn3bQ" sourceAmount="_992ECbn50GcVDRjD1WdnQ" targetAmount="oIRNpnRC2Um9PlliQqHMSQ" />
-                  </Children>
-                </Container>
-                <Parameter id="rH1jmGNj90q_4cg5cI4OkA" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" formula="164ALlmHhUOYzDjNb9tt8w" dim="Surface" quantityType="0" />
-              </Children>
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-            <Neighborhood id="Fevoys_lBEWGWzFl7rp8Fw" name="SmallIntestine_bc_PortalVein_bc" description="Neighborhood between Small Intestine/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="5Ye_xsRvs0WtJRsgL0Pz9w" secondNeighbor="UsK_koflU0aP-ubDRlslJQ">
-              <Tags>
-                <Tag value="SmallIntestine_bc_PortalVein_bc" />
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="LDsa-3WswEOJI7EIARTcuA" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Transport id="3WYtRA4TCkuz5wukHZjcpQ" name="MassTransferSinRBC2BloodPool_Pve" description="Mass transfer from Small Intestine:Blood Cells to Portal Vein: Blood Cells" mode="Logical" containerType="Other" dimension="Dimensionless" formula="5Af5FzSG7U2Gpa8Fd4izBA" sourceAmount="oIRNpnRC2Um9PlliQqHMSQ" targetAmount="F8UZepNEFEqiqDVPY4DDnA" />
-                  </Children>
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-              </Children>
-            </Neighborhood>
-            <Neighborhood id="_WsSgVIYFEu9099rAYKbKg" name="SmallIntestine_pls_SmallIntestine_int" description="Neighborhood between Small Intestine/Plasma and Small Intestine/Interstitial" mode="Logical" containerType="Other" firstNeighbor="_l2zQZC3T0igTnQWgWvr8Q" secondNeighbor="Bj_EPI79EUG7EwTh0uMizQ">
-              <Tags>
-                <Tag value="SmallIntestine_pls_SmallIntestine_int" />
-                <Tag value="Neighborhood: Plasma / Interstitial" />
-                <Tag value="Small intestine  neighborhood" />
-              </Tags>
-              <Children>
-                <Container id="NzQfRM-q3ECyPZ9qx9_-aQ" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="W_HfZChrDEWtj-fCUQeq4g" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" formula="-DEFSC4vn0ajeww6-OP5eg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="_mmpoxOEFUWxldobRroy_A" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" formula="UhphgGC0FEOChR4Fyh4FkQ" dim="Velocity" quantityType="0" />
-                    <Transport id="hi3Ddn3p7UWJ-ro2HZE28A" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Other" dimension="Dimensionless" formula="cs5hKi9o-kOOgzuzbQOdvg" sourceAmount="_992ECbn50GcVDRjD1WdnQ" targetAmount="My-p2ZyGt06nqZi24Wi_Wg" />
-                  </Children>
-                </Container>
-                <Parameter id="UVlLWuQaUE-Oe2XDf3Pwyw" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" formula="_dU_vxLns0Wc0Hx1iRuT9g" dim="Surface" quantityType="0" />
-              </Children>
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-            <Neighborhood id="ehoFyxvC00Cu9C-eu6xeBA" name="SmallIntestine_pls_PortalVein_pls" description="Neighborhood between Small Intestine/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="_l2zQZC3T0igTnQWgWvr8Q" secondNeighbor="t3RJcRrWZk6Yk-_IRw-vvA">
-              <Tags>
-                <Tag value="SmallIntestine_pls_PortalVein_pls" />
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="1W_rIwtR_UyOu0Obb43I2A" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Transport id="797P8mym9EeSh6Yhilhmzg" name="MassTransferSinPlasma2BloodPool_Pve" description="Mass transfer from Small Intestine:Plasma to Portal Vein: Plasma" mode="Logical" containerType="Other" dimension="Dimensionless" formula="HS0l8EkCQ0GmIHnVQNlI6Q" sourceAmount="_992ECbn50GcVDRjD1WdnQ" targetAmount="3epVIeHC_0m65IYsJjSaDQ" />
-                  </Children>
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-            <Neighborhood id="vAdWztNEeEO7WvqS4d86MA" name="SmallIntestine_int_SmallIntestine_cell" description="Neighborhood between Small Intestine/Interstitial and Small Intestine/Intracellular" mode="Logical" containerType="Other" firstNeighbor="Bj_EPI79EUG7EwTh0uMizQ" secondNeighbor="YXKwCrs0YkqN38apvgc6LQ">
-              <Tags>
-                <Tag value="SmallIntestine_int_SmallIntestine_cell" />
-                <Tag value="Neighborhood: Interstitial / Intracellular" />
-                <Tag value="Small intestine  neighborhood" />
-              </Tags>
-              <Children>
-                <Container id="MMM4y2BU7Ee0jo6A6vczKA" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="Nr6Vg7a210udQh1NB0dckA" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="xQZ40Mn0s0Wf7QlpiyG1_w" dim="Velocity" quantityType="0" />
-                    <Parameter id="RR1C9KM9dkquTmomZzbHMw" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="3-LEyoK2GEOuCEV2otw_AQ" dim="Velocity" quantityType="0" />
-                    <Parameter id="W3l3zTy9vEeg0SVj7leA_w" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="DIQILkkEz06QbATD24Bttw" dim="Flow (volume)" quantityType="0" />
-                    <Parameter id="nZwM-Any7EKe7bXG-8-uew" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="GRkU-raPfUeXS_32oxTzjQ" dim="Flow (volume)" quantityType="0" />
-                    <Parameter id="40bub1YUCUuwAIfh8OLJjw" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="ItAyjfTXG0mL4A9S4N7ITg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="5tPArej2FE-n7bNDsFIAog" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="-5QUp3qyFkGwyOG9_-M1nw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="X-LqIhyuIkSgXIO6wzaBaQ" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" formula="jPyKUSRbhk-jwBTY55VKow" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="wWadHb3tmUeTNoe-A67RQA" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" formula="3cJBFwQjyUqzb_kQadzpHA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="TOEnOAtZnEKGg-Oki0STzQ" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" formula="c5popDFczEqzrHUDzoOb2w" dim="Dimensionless" quantityType="0" />
-                    <Transport id="HlnVED2lzkWZUpyo5QKg7A" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Other" dimension="Dimensionless" formula="oppuAuXQM06HYhk_wpcLUg" sourceAmount="My-p2ZyGt06nqZi24Wi_Wg" targetAmount="70LQvrSA1kWlrHYaR8Ed2w" />
-                  </Children>
-                </Container>
-                <Parameter id="oxQRceevnkuC32v9MTi5Pg" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" formula="1d2DL4QYNkO172g9xluOEQ" dim="Surface" quantityType="0" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="c__qUrrM1EGfJQGXXMe-QA" name="SmallIntestine_bc_LowerIleum_bc" description="Neighborhood between Small Intestine/Blood Cells_ and Lower Ileum/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="5Ye_xsRvs0WtJRsgL0Pz9w" secondNeighbor="y0laXWaK_0ejrydIy9XoSA">
-              <Tags>
-                <Tag value="SmallIntestine_bc_LowerIleum_bc" />
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="VVHRIqaNr0G8JzWy2YnInw" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="opa_YDwmHU-YrxvzrSEiDA" name="Mass transfer rate (intestine to mucosa blood cells)" description="Mass transfer rate (intestine to mucosa blood cells)" persistable="0" isFixedValue="0" formula="DbXOOVk9ikeUTszqJ1Spgg" dim="Rate" quantityType="0" />
-                    <Transport id="20tZBl93l0q3W1R3p6gTBQ" name="MassTransferSINToMucosaBC" description="Mass transfer from Small Intestine:Blood Cells to Mucosa: Blood Cells" mode="Logical" containerType="Other" dimension="Dimensionless" formula="RYzae6dNJ0iimDsUC6olTg" sourceAmount="oIRNpnRC2Um9PlliQqHMSQ" targetAmount="FMCNNfjTpk2M8Oq8kAgVDA" />
-                  </Children>
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-              </Children>
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-            <Neighborhood id="jfUqOG4eaEOGdhpio2a9OA" name="SmallIntestine_pls_Duodenum_pls" description="Neighborhood between Small Intestine/Plasma_ and Duodenum/Plasma" mode="Logical" containerType="Other" firstNeighbor="_l2zQZC3T0igTnQWgWvr8Q" secondNeighbor="qpsNmcf0yECPn6bPfvoWbA">
-              <Tags>
-                <Tag value="SmallIntestine_pls_Duodenum_pls" />
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="CpKmFOqRVUejM5kpaZfneA" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="6XGFxQj_Vkm0GwoE3ZozWQ" name="Mass transfer rate (intestine to mucosa plasma)" description="Mass transfer rate (intestine to mucosa plasma)" persistable="0" isFixedValue="0" formula="94V-S13eSk-wTTb7eKlzZA" dim="Rate" quantityType="0" />
-                    <Transport id="VcAnQTO9kkS_5Pq4ZH7UJA" name="MassTransferSINToMucosaPlasma" description="Mass transfer from Small Intestine:Plasma to Mucosa: Plasma" mode="Logical" containerType="Other" dimension="Dimensionless" formula="NrfyZveTpEOj_I5KF1OIGw" sourceAmount="_992ECbn50GcVDRjD1WdnQ" targetAmount="NuXtwyVbBESYGyhe3qyqWQ" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="M_QUQLtnZ0qzkSrSTUce3Q" name="SmallIntestine_bc_Duodenum_bc" description="Neighborhood between Small Intestine/Blood Cells_ and Duodenum/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="5Ye_xsRvs0WtJRsgL0Pz9w" secondNeighbor="G67GNfr5nUejQBYiVNI7Gw">
-              <Tags>
-                <Tag value="SmallIntestine_bc_Duodenum_bc" />
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="3-iVL4Ka0kqCWNI7Ub1b_w" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="b6OwVcJ-eU-oHRPIbK9OZQ" name="Mass transfer rate (intestine to mucosa blood cells)" description="Mass transfer rate (intestine to mucosa blood cells)" persistable="0" isFixedValue="0" formula="KxtzIbbgn0aCaetuv7EkjQ" dim="Rate" quantityType="0" />
-                    <Transport id="yNKV36nwP0y0I0T1RrcOPg" name="MassTransferSINToMucosaBC" description="Mass transfer from Small Intestine:Blood Cells to Mucosa: Blood Cells" mode="Logical" containerType="Other" dimension="Dimensionless" formula="y0nBBlnik0iBtWKhnlNSFQ" sourceAmount="oIRNpnRC2Um9PlliQqHMSQ" targetAmount="I-wcOfVzhUubhukFSm8Z-A" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="G4R51lV7p06ptWoXfbH-nQ" name="SmallIntestine_pls_UpperJejunum_pls" description="Neighborhood between Small Intestine/Plasma_ and Upper Jejunum/Plasma" mode="Logical" containerType="Other" firstNeighbor="_l2zQZC3T0igTnQWgWvr8Q" secondNeighbor="qeqwoTSkakOVMFqQIp36Rw">
-              <Tags>
-                <Tag value="SmallIntestine_pls_UpperJejunum_pls" />
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="5bQcp4mF9kearbFfhNudNA" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="nen3_o9ZZUas3Ubal1TkrA" name="Mass transfer rate (intestine to mucosa plasma)" description="Mass transfer rate (intestine to mucosa plasma)" persistable="0" isFixedValue="0" formula="VpoBAPXBk0W3Lk6dSjCgHQ" dim="Rate" quantityType="0" />
-                    <Transport id="UqT_SATdukWY98UPS1KfPA" name="MassTransferSINToMucosaPlasma" description="Mass transfer from Small Intestine:Plasma to Mucosa: Plasma" mode="Logical" containerType="Other" dimension="Dimensionless" formula="XqQb_J_svUqJevXT9qR6fQ" sourceAmount="_992ECbn50GcVDRjD1WdnQ" targetAmount="Cyoj-iIBBUK7nqW_avA9uw" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="6DtjUoR0fku_TcAsnmdUQQ" name="SmallIntestine_bc_UpperJejunum_bc" description="Neighborhood between Small Intestine/Blood Cells_ and Upper Jejunum/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="5Ye_xsRvs0WtJRsgL0Pz9w" secondNeighbor="bkf1EKQC6UWHf1_K1uz-Hg">
-              <Tags>
-                <Tag value="SmallIntestine_bc_UpperJejunum_bc" />
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="xJGoQI7xok6f_YnPv0KOrg" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="28lgABKcekGb5l8J3F3eNA" name="Mass transfer rate (intestine to mucosa blood cells)" description="Mass transfer rate (intestine to mucosa blood cells)" persistable="0" isFixedValue="0" formula="XEZU4kF6AUK9Bil0SqY4yg" dim="Rate" quantityType="0" />
-                    <Transport id="W9UQ71LlekyQtUXEzHm0cA" name="MassTransferSINToMucosaBC" description="Mass transfer from Small Intestine:Blood Cells to Mucosa: Blood Cells" mode="Logical" containerType="Other" dimension="Dimensionless" formula="1KcpTsIi50ehQetm__dsiw" sourceAmount="oIRNpnRC2Um9PlliQqHMSQ" targetAmount="9xjcN-quk0yrAPxO3xJMjA" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="zSsMDjQgLUaFIBrmAWlO-g" name="SmallIntestine_pls_LowerJejunum_pls" description="Neighborhood between Small Intestine/Plasma_ and Lower Jejunum/Plasma" mode="Logical" containerType="Other" firstNeighbor="_l2zQZC3T0igTnQWgWvr8Q" secondNeighbor="4Q7zgvuqcE-QpUYXuYeQwA">
-              <Tags>
-                <Tag value="SmallIntestine_pls_LowerJejunum_pls" />
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="P5coLCiPmkigANU2XQpx-Q" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="ITrH6fHrbky6c1tvfIqpzA" name="Mass transfer rate (intestine to mucosa plasma)" description="Mass transfer rate (intestine to mucosa plasma)" persistable="0" isFixedValue="0" formula="pwy50mAqJkGiUIoGhp932Q" dim="Rate" quantityType="0" />
-                    <Transport id="STuHal_GEkuL7CWGpZz1ag" name="MassTransferSINToMucosaPlasma" description="Mass transfer from Small Intestine:Plasma to Mucosa: Plasma" mode="Logical" containerType="Other" dimension="Dimensionless" formula="WDcKadvQ90Sd7FaQKjSyvw" sourceAmount="_992ECbn50GcVDRjD1WdnQ" targetAmount="IBK3hooVzE2t9QgNnGZ_0w" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="B3GMPJEZgkSJB6zwfyaArw" name="SmallIntestine_bc_LowerJejunum_bc" description="Neighborhood between Small Intestine/Blood Cells_ and Lower Jejunum/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="5Ye_xsRvs0WtJRsgL0Pz9w" secondNeighbor="MN94QcuVH0aTgduRFgCruw">
-              <Tags>
-                <Tag value="SmallIntestine_bc_LowerJejunum_bc" />
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="8MyYu6vjT0qPIimmsHJtQw" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="VFJesc71X0G_A_yVvrPmhg" name="Mass transfer rate (intestine to mucosa blood cells)" description="Mass transfer rate (intestine to mucosa blood cells)" persistable="0" isFixedValue="0" formula="6rr25GFMwkmzXVx4jb1c1Q" dim="Rate" quantityType="0" />
-                    <Transport id="nLEgnHx5Y02g2qzseW1llA" name="MassTransferSINToMucosaBC" description="Mass transfer from Small Intestine:Blood Cells to Mucosa: Blood Cells" mode="Logical" containerType="Other" dimension="Dimensionless" formula="F6NxchowgUGLW99AhYXJHw" sourceAmount="oIRNpnRC2Um9PlliQqHMSQ" targetAmount="pkwIe2c8m0C2ShdFKX-RLw" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="FcBvbY5W7UWGelnv3vJzqA" name="SmallIntestine_pls_UpperIleum_pls" description="Neighborhood between Small Intestine/Plasma_ and Upper Ileum/Plasma" mode="Logical" containerType="Other" firstNeighbor="_l2zQZC3T0igTnQWgWvr8Q" secondNeighbor="eqxADnXJ7U-yx7RZ9RRnGQ">
-              <Tags>
-                <Tag value="SmallIntestine_pls_UpperIleum_pls" />
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="lKarGM0uSUC0kgzM58cKFg" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="bOTYZMa1CkarbmahI2ZcVw" name="Mass transfer rate (intestine to mucosa plasma)" description="Mass transfer rate (intestine to mucosa plasma)" persistable="0" isFixedValue="0" formula="5VXov1xOe06LuOIXbdFoeA" dim="Rate" quantityType="0" />
-                    <Transport id="8OS_xuMIUEGye3lbe9o6sA" name="MassTransferSINToMucosaPlasma" description="Mass transfer from Small Intestine:Plasma to Mucosa: Plasma" mode="Logical" containerType="Other" dimension="Dimensionless" formula="Wyevfo5JhEiNeQZfr2ZjLA" sourceAmount="_992ECbn50GcVDRjD1WdnQ" targetAmount="3LnxhiZCq0-_1-jmaYhb8w" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="mTwjNEuI1UO-SvTWfKOLqQ" name="SmallIntestine_bc_UpperIleum_bc" description="Neighborhood between Small Intestine/Blood Cells_ and Upper Ileum/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="5Ye_xsRvs0WtJRsgL0Pz9w" secondNeighbor="O523UhgKSkeprp67LMaDag">
-              <Tags>
-                <Tag value="SmallIntestine_bc_UpperIleum_bc" />
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="Ln5dT_cQlUmX_-Yt9UOqfA" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="gqlxdnPbf069WmXd5TPlNA" name="Mass transfer rate (intestine to mucosa blood cells)" description="Mass transfer rate (intestine to mucosa blood cells)" persistable="0" isFixedValue="0" formula="ZcUsSHdFF0uJyFcHrKF2BA" dim="Rate" quantityType="0" />
-                    <Transport id="LV_TpZPngEqJpoJCaGFSdg" name="MassTransferSINToMucosaBC" description="Mass transfer from Small Intestine:Blood Cells to Mucosa: Blood Cells" mode="Logical" containerType="Other" dimension="Dimensionless" formula="3gS9HWCng0uTaJxvpwAV6w" sourceAmount="oIRNpnRC2Um9PlliQqHMSQ" targetAmount="W8KLhlsWkU6-nxbVlLgfDA" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="JRev0F4r40S8Co_Iurv3-Q" name="Lumen_lil_LowerIleum_pls" description="Neighborhood between Lumen/Lower Ileum and Mucosa/Lower Ileum/Plasma" mode="Logical" containerType="Other" firstNeighbor="Lk6M-N8TdEOKfd5gHwDSMQ" secondNeighbor="2U7EZ2uO6USg9Rq74oJ7og">
-              <Tags>
-                <Tag value="Lumen_lil_LowerIleum_pls" />
-                <Tag value="Neighborhood: LowerIleum / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="30VrubomZU6_YdyPkoRKQA" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="dqBXQeVRWkmFn-IvF1FvLA" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" formula="10B7tdCq4USjaqlFgKmEAA" dim="Rate" quantityType="0" />
-                    <Transport id="82t6hCGOpEy-4vBn3yj-fw" name="DrugAbsorption_para" description="Drug absorption paracellular" mode="Logical" containerType="Other" dimension="Dimensionless" formula="iQR3m0GU8UCTnYYqjAZSMA" sourceAmount="2rK9g1SMCEOsiulUb04Htg" targetAmount="bh7HbBF4F0WuPbCIz5_eSQ" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="N_ctpq_PsE-srZbNXXq-ng" name="SmallIntestine_pls_LowerIleum_pls" description="Neighborhood between Small Intestine/Plasma_ and Lower Ileum/Plasma" mode="Logical" containerType="Other" firstNeighbor="_l2zQZC3T0igTnQWgWvr8Q" secondNeighbor="2U7EZ2uO6USg9Rq74oJ7og">
-              <Tags>
-                <Tag value="SmallIntestine_pls_LowerIleum_pls" />
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="-L13O_rMtkW2lOHQ3GdiZQ" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="SiMjDc5Cv0KIJs1KrWEzQA" name="Mass transfer rate (intestine to mucosa plasma)" description="Mass transfer rate (intestine to mucosa plasma)" persistable="0" isFixedValue="0" formula="6DVDs94st0-D3mCm4a0-QA" dim="Rate" quantityType="0" />
-                    <Transport id="sszrX7aaRUGEcQJ58-K0_Q" name="MassTransferSINToMucosaPlasma" description="Mass transfer from Small Intestine:Plasma to Mucosa: Plasma" mode="Logical" containerType="Other" dimension="Dimensionless" formula="Nf8QX5nRsEKUtrEx9Kl11g" sourceAmount="_992ECbn50GcVDRjD1WdnQ" targetAmount="bh7HbBF4F0WuPbCIz5_eSQ" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="81mdiYs-60aqDGBAhYpx4g" name="LowerIleum_pls_PortalVein_pls" description="Neighborhood between Lower Ileum/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="2U7EZ2uO6USg9Rq74oJ7og" secondNeighbor="t3RJcRrWZk6Yk-_IRw-vvA">
-              <Tags>
-                <Tag value="LowerIleum_pls_PortalVein_pls" />
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="97yAaMfeak6J0OIz5rco0Q" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="DdpStOzjOEivwgeiBUIA3w" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" persistable="0" isFixedValue="0" formula="jjclMX3vg0evUeuwCh8NCw" dim="Rate" quantityType="0" />
-                    <Transport id="BCfunl7kJ02yoMazgsamfA" name="MassTransferMucosaToPvePlasma" description="Mass transfer from Mucosa:Plasma To Portal Vein: Plasma" mode="Logical" containerType="Other" dimension="Dimensionless" formula="ClWpkXMgGEWtXfHiFiWMeQ" sourceAmount="bh7HbBF4F0WuPbCIz5_eSQ" targetAmount="3epVIeHC_0m65IYsJjSaDQ" />
-                  </Children>
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-              </Children>
-            </Neighborhood>
-            <Neighborhood id="DKan6eNiXUqoA2QhLi47ag" name="LowerIleum_bc_PortalVein_bc" description="Neighborhood between Lower Ileum/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="y0laXWaK_0ejrydIy9XoSA" secondNeighbor="UsK_koflU0aP-ubDRlslJQ">
-              <Tags>
-                <Tag value="LowerIleum_bc_PortalVein_bc" />
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="W8sFa6xsFkSGTJZV_OZMHw" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="pR3BBcouUEGDYzKvZKBNVg" name="Mass transfer rate (mucosa to portal vein blood cells)" description="Mass transfer rate (mucosa to portal vein blood cells)" persistable="0" isFixedValue="0" formula="GxqP_iri1UGVqcLuATUr5w" dim="Rate" quantityType="0" />
-                    <Transport id="mmU_m2OzUUuspYILWG8HJA" name="MassTransferMucosaToPveBC" description="Mass transfer from Mucosa:Blood Cells To Portal Vein: Blood Cells" mode="Logical" containerType="Other" dimension="Dimensionless" formula="D5_H-4EK6ECRcOMO70U3gw" sourceAmount="FMCNNfjTpk2M8Oq8kAgVDA" targetAmount="F8UZepNEFEqiqDVPY4DDnA" />
-                  </Children>
-                </Container>
-              </Children>
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-            <Neighborhood id="Ssgi3QZ4GU2oR8TcF3bH2A" name="Lumen_lil_LowerIleum_cell" description="Neighborhood between Lumen/Lower Ileum and Mucosa/Lower Ileum/Intracellular" mode="Logical" containerType="Other" firstNeighbor="Lk6M-N8TdEOKfd5gHwDSMQ" secondNeighbor="pZKqZ19W4kqEFXqZkxgETw">
-              <Tags>
-                <Tag value="Lumen_lil_LowerIleum_cell" />
-                <Tag value="Neighborhood: LowerIleum / Intracellular" />
-              </Tags>
-              <Children>
-                <Container id="fB1o4IFmr0C92TWLsw3I3Q" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="nfZ_hSD4vEawHJXFQSiIgg" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="LkNboiryhkGVzCBDg0Yc9g" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="LAI6fOCWXkCbDOn-zrPFGg" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="q3UCyneZi0CZtpN2SylR9A" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="x-GEmvGSy0a5aKbjk_6BbQ" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="aMN4XH4f10CaDLbJlRvOYg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="pZoM7lle80mC3spbLyGOyg" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="PdH_puI8x0SM-tI3E7CmgQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="Yn0T3dSy5UmWHqApl2pE8Q" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="Aw8vq5KCWEOCAoMQrVN6FQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="ANseC5sv9EW9lQF2lNIUqg" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="SzK_8omVIE-vZmY_eihelA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="qSYwbdb9zkCRJ6kBmOW6Eg" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="k8hWpEIpF0KjTAC5NbdvbA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="j6IzL1JBhEmfP2BZB9smAw" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="3uQ_8bks5kSiesc_SOfNwA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="G1pDr2QolUSG-JBgKxvvHA" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="aJba9lRteUSyHr8r46GXyw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="d4RyS5IaXkqcC2v5lK9Xow" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="URpIha-lq0aw2n8vyrHSyg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="HjH-DPHPR0W7QMJA1tzcUg" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="AkRbpFWVBEe9u5MbHZxalg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="gEiDiPVUTk2rT0Xbudq_1Q" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" formula="bAFj5KPL3kOLiJND5UNHjw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="EBx0S01hUUacwLAxxX3hrA" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" formula="h9PB3F_RjkKR4KVhQ6N4vw" dim="Rate" quantityType="0" />
-                    <Parameter id="OfVNUbIR10Oqmj9mWT__ww" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="RJRIddynfU-kStoSCNdNxQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="5hP5pFWZ10SZdFWs1MtTpA" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="zPRuJnFKD0GXaHOzSoB7SQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="65AUECBwkESQEAcOPHwzjg" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" formula="N5RnvvQPCkWvLoSajLEiRA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="TS3DODvcS0Clt6EzD4ULbg" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="chT6KHUUfkiHKSFiIRoCFw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="A5cXUqLXZ0CsWkMaaHJMew" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="QhOaqKlZhkuOHqM8A6FK-A" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="rH2vgToiWUm5Locbl60MIw" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="FsqPz2ggZUC9pPgQo0Y4bw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="ZdVEwzUcv0qqoPyRrt5Qeg" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="S_qjrFFhlUei9mGuxmLKJg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="9nwJ03kOaU2X82oWy0k48A" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="xM7lqQL_aEy-cELqFKBf3w" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="oTCLt7Kpzk610r7U5mJB5g" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="WFbKuaD2_Uut_BXIFvFxpA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="n-7OX5K2H0aQlW6uIB_irw" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="AAnDqAX9zUqoNDW37i4yBQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="DgEaosjHuk-DAztFzAuapA" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="QWN9mrAel0-mdjkWIwyAtw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="AczLzEb-P0eBNgQAZBdRHA" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="F6FIReabwUqeLEL5fA8UaA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="1X6fTLPFd0u2CYUN-RCA5Q" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="Kf9Bxa2_b0Geq1rJPr-UGQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="qGdvhf54lECP4ZSASLg-og" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="S5rOyojRIUmpgOV6TPakRQ" dim="Dimensionless" quantityType="0" />
-                    <Transport id="qyfoe7nD4kC6EuWlzefbcg" name="DrugAbsorption_trans" description="Drug absorption transcellular" mode="Logical" containerType="Other" dimension="Dimensionless" formula="CAfKMsBU3kCeLU0CqWk7SA" sourceAmount="2rK9g1SMCEOsiulUb04Htg" targetAmount="RReUSXdPAki3FARiRF47pg" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="djy8oGZNCECWUaKfe1zvqw" name="LargeIntestine_bc_Rectum_bc" description="Neighborhood between Large Intestine/Blood Cells_ and Rectum/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="wMP3kbtQaUKQg4QfYQVYGg" secondNeighbor="MFTNPY8lYUuHI3TkYqAe_Q">
-              <Tags>
-                <Tag value="LargeIntestine_bc_Rectum_bc" />
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="RG_slJXYME2ixpm-rsmH6Q" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="MdSECBaj4EiJzkMcBV_vEw" name="Mass transfer rate (intestine to mucosa blood cells)" description="Mass transfer rate (intestine to mucosa blood cells)" persistable="0" isFixedValue="0" formula="MG7Nu96KxEuvvtkCV1SpPg" dim="Rate" quantityType="0" />
-                    <Transport id="QeMnvWNwMkW2dlM3EhjHsQ" name="MassTransferLINToMucosaBC" description="Mass transfer from Large Intestine:Blood Cells to Mucosa: Blood Cells" mode="Logical" containerType="Other" dimension="Dimensionless" formula="In0HvHW-zkmp9ZRXRxlOnw" sourceAmount="BbZT4ZKz3ES0AnolBdIDWw" targetAmount="bw0eSCTFWkiTM1Eimt2DBQ" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="S19AjzpHFEGmaCmChymeBw" name="LargeIntestine_pls_Rectum_pls" description="Neighborhood between Large Intestine/Plasma_ and Rectum/Plasma" mode="Logical" containerType="Other" firstNeighbor="kX3NLMXH5kGsPE4c_l2A7A" secondNeighbor="zhw7k9aVu0eeZFACLC99xw">
-              <Tags>
-                <Tag value="LargeIntestine_pls_Rectum_pls" />
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="r50QQdFjrU2EwtIq8GR-Pw" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="C664n2Lo60O8LXcyhMyGVw" name="Mass transfer rate (intestine to mucosa plasma)" description="Mass transfer rate (intestine to mucosa plasma)" persistable="0" isFixedValue="0" formula="Nvdr9nyIDU-gkre5gjrn6Q" dim="Rate" quantityType="0" />
-                    <Transport id="vu64YYU6DEisxWq2h_vYKA" name="MassTransferLINToMucosaPlasma" description="Mass transfer from Large Intestine:Plasma to Mucosa: Plasma" mode="Logical" containerType="Other" dimension="Dimensionless" formula="UO9miYsNGEity-nTbx5IXA" sourceAmount="CeR0DerUEk6Aqx58R2Mk4Q" targetAmount="r7ItQnvBJ0efZqobBY36mQ" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="b6FT7Ozg5k2OkVXEXY7qFA" name="LargeIntestine_bc_ColonSigmoid_bc" description="Neighborhood between Large Intestine/Blood Cells_ and Colon Sigmoid/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="wMP3kbtQaUKQg4QfYQVYGg" secondNeighbor="VFAajW768UeoKlpXQfnVNA">
-              <Tags>
-                <Tag value="LargeIntestine_bc_ColonSigmoid_bc" />
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="GNBMT_m7_k2Z_aJxHhdbXQ" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="DyJrxb77uESB0iogQBojTw" name="Mass transfer rate (intestine to mucosa blood cells)" description="Mass transfer rate (intestine to mucosa blood cells)" persistable="0" isFixedValue="0" formula="xlbW3h5JEU2SBPXGekkffQ" dim="Rate" quantityType="0" />
-                    <Transport id="_SROIQR8qEGNPSDu05foTw" name="MassTransferLINToMucosaBC" description="Mass transfer from Large Intestine:Blood Cells to Mucosa: Blood Cells" mode="Logical" containerType="Other" dimension="Dimensionless" formula="V7ViIYTPrkWWhaDItDPaiQ" sourceAmount="BbZT4ZKz3ES0AnolBdIDWw" targetAmount="bftHsV58IEij5P2Nw6mjNA" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="trWYV6p_XUCMFxWleraGNQ" name="LargeIntestine_pls_ColonSigmoid_pls" description="Neighborhood between Large Intestine/Plasma_ and Colon Sigmoid/Plasma" mode="Logical" containerType="Other" firstNeighbor="kX3NLMXH5kGsPE4c_l2A7A" secondNeighbor="OueVYReP4UKcfdpQe9-xDg">
-              <Tags>
-                <Tag value="LargeIntestine_pls_ColonSigmoid_pls" />
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="Ke96ivF4Jkq0yYXCGBknEA" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="gM28NYcnKE2v7hSEJ6MmKw" name="Mass transfer rate (intestine to mucosa plasma)" description="Mass transfer rate (intestine to mucosa plasma)" persistable="0" isFixedValue="0" formula="wu8VWaWeM0OOeTnkotJkog" dim="Rate" quantityType="0" />
-                    <Transport id="Huj8atuSBkKx0Lo2XBdvkA" name="MassTransferLINToMucosaPlasma" description="Mass transfer from Large Intestine:Plasma to Mucosa: Plasma" mode="Logical" containerType="Other" dimension="Dimensionless" formula="baiFjX2AKUWgN5FevMYA-Q" sourceAmount="CeR0DerUEk6Aqx58R2Mk4Q" targetAmount="Ecj_rn201Uq4oPkYy48ZIA" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="SIYb22YIt0GlPkdoQoy4qQ" name="LargeIntestine_bc_ColonDescendens_bc" description="Neighborhood between Large Intestine/Blood Cells_ and Colon Descendens/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="wMP3kbtQaUKQg4QfYQVYGg" secondNeighbor="atTfkMp6oU6CKOflJP6z3w">
-              <Tags>
-                <Tag value="LargeIntestine_bc_ColonDescendens_bc" />
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="ik3pbdJxE0O83SOaX0o8uA" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="7G_r4D_a2EmwCvi5se7rDg" name="Mass transfer rate (intestine to mucosa blood cells)" description="Mass transfer rate (intestine to mucosa blood cells)" persistable="0" isFixedValue="0" formula="6j0aInE4qk2qYtHwt5JzIQ" dim="Rate" quantityType="0" />
-                    <Transport id="m0SdRH1kH06aZ4jyTkvjTA" name="MassTransferLINToMucosaBC" description="Mass transfer from Large Intestine:Blood Cells to Mucosa: Blood Cells" mode="Logical" containerType="Other" dimension="Dimensionless" formula="Mb3RLDmzNEq6Umr5NHznqQ" sourceAmount="BbZT4ZKz3ES0AnolBdIDWw" targetAmount="1EnMTQCxHkmgkxQCMDxj7Q" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="05HRR4SnmUqKWun6STGIhA" name="LargeIntestine_pls_ColonDescendens_pls" description="Neighborhood between Large Intestine/Plasma_ and Colon Descendens/Plasma" mode="Logical" containerType="Other" firstNeighbor="kX3NLMXH5kGsPE4c_l2A7A" secondNeighbor="PJgrM6BcSUav3cqJRrmkNA">
-              <Tags>
-                <Tag value="LargeIntestine_pls_ColonDescendens_pls" />
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="8xeYBuJ1WkuhXe4-OqF6JA" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="qXv152UdFkuD6SyAqxjljQ" name="Mass transfer rate (intestine to mucosa plasma)" description="Mass transfer rate (intestine to mucosa plasma)" persistable="0" isFixedValue="0" formula="PbSVdCempE2AUwAnCWd7FA" dim="Rate" quantityType="0" />
-                    <Transport id="36oT9QBnmUaWucVvL7MU9Q" name="MassTransferLINToMucosaPlasma" description="Mass transfer from Large Intestine:Plasma to Mucosa: Plasma" mode="Logical" containerType="Other" dimension="Dimensionless" formula="Xu5qQaPM20u45at9Vn7byA" sourceAmount="CeR0DerUEk6Aqx58R2Mk4Q" targetAmount="W3SdEs2fVUKbnj5EqVBLXw" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="5-n22vh_3EiBcH83E-HjKQ" name="LargeIntestine_pls_ColonTransversum_pls" description="Neighborhood between Large Intestine/Plasma_ and Colon Transversum/Plasma" mode="Logical" containerType="Other" firstNeighbor="kX3NLMXH5kGsPE4c_l2A7A" secondNeighbor="j1XM0vRHAEaTiu2blg0NgQ">
-              <Tags>
-                <Tag value="LargeIntestine_pls_ColonTransversum_pls" />
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="Ack5wtMQtUeevWOPl0T1bQ" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="JDH4SZAVXkO32hzgP1Ne2g" name="Mass transfer rate (intestine to mucosa plasma)" description="Mass transfer rate (intestine to mucosa plasma)" persistable="0" isFixedValue="0" formula="NBgrNum5ZUuS9Z9MFrEUiQ" dim="Rate" quantityType="0" />
-                    <Transport id="CzjB891ed0-wD5Fb5UTZ9Q" name="MassTransferLINToMucosaPlasma" description="Mass transfer from Large Intestine:Plasma to Mucosa: Plasma" mode="Logical" containerType="Other" dimension="Dimensionless" formula="kT0N3WHPrEmk8PkzLQgbYg" sourceAmount="CeR0DerUEk6Aqx58R2Mk4Q" targetAmount="SLgG3jH9c0WpTyMIPQBI2g" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="gOuqBS1q4EapWRzWA8TpMA" name="LargeIntestine_bc_ColonAscendens_bc" description="Neighborhood between Large Intestine/Blood Cells_ and Colon Ascendens/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="wMP3kbtQaUKQg4QfYQVYGg" secondNeighbor="aBWYhB1S5EmhC-3vnT5kZg">
-              <Tags>
-                <Tag value="LargeIntestine_bc_ColonAscendens_bc" />
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="-ImUp9pB5kmHqIOi_WJINg" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="Ntuf5H4tzkmDF_NH7xRbAQ" name="Mass transfer rate (intestine to mucosa blood cells)" description="Mass transfer rate (intestine to mucosa blood cells)" persistable="0" isFixedValue="0" formula="LH0pRcPlRkK8VGHHezYKMQ" dim="Rate" quantityType="0" />
-                    <Transport id="7UT7kpCFo0G8dWR_jLKxlQ" name="MassTransferLINToMucosaBC" description="Mass transfer from Large Intestine:Blood Cells to Mucosa: Blood Cells" mode="Logical" containerType="Other" dimension="Dimensionless" formula="L9le0DYwaEyQ_BQ2nyp_7Q" sourceAmount="BbZT4ZKz3ES0AnolBdIDWw" targetAmount="2LtEnxRQ-E68v82BoICp1A" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="0COWdS-oyEmdQmYgDgOe0A" name="LargeIntestine_pls_ColonAscendens_pls" description="Neighborhood between Large Intestine/Plasma_ and Colon Ascendens/Plasma" mode="Logical" containerType="Other" firstNeighbor="kX3NLMXH5kGsPE4c_l2A7A" secondNeighbor="BkigLfGvSkiooZ67DLK2NQ">
-              <Tags>
-                <Tag value="LargeIntestine_pls_ColonAscendens_pls" />
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="gpx8nuWzqE2I7iErPDELNQ" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="XcIYEn5Vqk2RN4R_Q2sn3Q" name="Mass transfer rate (intestine to mucosa plasma)" description="Mass transfer rate (intestine to mucosa plasma)" persistable="0" isFixedValue="0" formula="__5Ad1eoQUqtVZPYeN0ttw" dim="Rate" quantityType="0" />
-                    <Transport id="XDgYXgjZvkehuzX7w-BOnA" name="MassTransferLINToMucosaPlasma" description="Mass transfer from Large Intestine:Plasma to Mucosa: Plasma" mode="Logical" containerType="Other" dimension="Dimensionless" formula="I4OQa5n-30mtUl8O_RZGnQ" sourceAmount="CeR0DerUEk6Aqx58R2Mk4Q" targetAmount="6ewOCi0jbU6RbncNeaX1hw" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="-gyo3HdxDEK9qjQ_qQyhHg" name="LargeIntestine_bc_Caecum_bc" description="Neighborhood between Large Intestine/Blood Cells_ and Cecum/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="wMP3kbtQaUKQg4QfYQVYGg" secondNeighbor="z3nIn6C3j0yVWC-W8t3Ztg">
-              <Tags>
-                <Tag value="LargeIntestine_bc_Caecum_bc" />
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="LV2wPEDr7E6OdobMI5wyGg" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="G6jlxZPbhUe8FWuncpShgg" name="Mass transfer rate (intestine to mucosa blood cells)" description="Mass transfer rate (intestine to mucosa blood cells)" persistable="0" isFixedValue="0" formula="EHCs19e5yECo6xIgM5w_Jw" dim="Rate" quantityType="0" />
-                    <Transport id="8Jldsj9RyEarBlX0E3Zaqg" name="MassTransferLINToMucosaBC" description="Mass transfer from Large Intestine:Blood Cells to Mucosa: Blood Cells" mode="Logical" containerType="Other" dimension="Dimensionless" formula="iz16tNbe4kCqjDbn3EiSKQ" sourceAmount="BbZT4ZKz3ES0AnolBdIDWw" targetAmount="Bdz3BSeKVE6ApvHc1Oikmg" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="zRY31xXFaE6-apB7dgArng" name="LargeIntestine_pls_Caecum_pls" description="Neighborhood between Large Intestine/Plasma_ and Cecum/Plasma" mode="Logical" containerType="Other" firstNeighbor="kX3NLMXH5kGsPE4c_l2A7A" secondNeighbor="l8icBJ2uN0KH4u_hLlRE-Q">
-              <Tags>
-                <Tag value="LargeIntestine_pls_Caecum_pls" />
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="8JFqwLCXmU2YOJT5QGvI4A" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="_R4T7r97nUGNjMGAz74zag" name="Mass transfer rate (intestine to mucosa plasma)" description="Mass transfer rate (intestine to mucosa plasma)" persistable="0" isFixedValue="0" formula="4t4VHVyfzk-XikcC7WEvMA" dim="Rate" quantityType="0" />
-                    <Transport id="2RCXJCEsbkCXCg7ipdCh-w" name="MassTransferLINToMucosaPlasma" description="Mass transfer from Large Intestine:Plasma to Mucosa: Plasma" mode="Logical" containerType="Other" dimension="Dimensionless" formula="hpdzWC8ql0icwxOFmjInrA" sourceAmount="CeR0DerUEk6Aqx58R2Mk4Q" targetAmount="0BQVZSFbd0yvGdZJo-TkmQ" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="0LVyPWwTUE-Kc_Ltn8RizA" name="LargeIntestine_bc_ColonTransversum_bc" description="Neighborhood between Large Intestine/Blood Cells_ and Colon Transversum/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="wMP3kbtQaUKQg4QfYQVYGg" secondNeighbor="4h08SDSRP0uZygWcIRA7mg">
-              <Tags>
-                <Tag value="LargeIntestine_bc_ColonTransversum_bc" />
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="ec2DW4MLWEOOWOTmr7vPRw" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="NDSZhfVy7kau1TM9PrsINg" name="Mass transfer rate (intestine to mucosa blood cells)" description="Mass transfer rate (intestine to mucosa blood cells)" persistable="0" isFixedValue="0" formula="iHb6Rai0-km8zaWfQxmDpQ" dim="Rate" quantityType="0" />
-                    <Transport id="B3LazjsBSEmgpbP33P3gAg" name="MassTransferLINToMucosaBC" description="Mass transfer from Large Intestine:Blood Cells to Mucosa: Blood Cells" mode="Logical" containerType="Other" dimension="Dimensionless" formula="smBoXR3hYk-BylBZdOKSlQ" sourceAmount="BbZT4ZKz3ES0AnolBdIDWw" targetAmount="DQ3BvfhWu0maydUENsDylg" />
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-            <Neighborhood id="WgPaV4hQwE6wb5F6BmzWcw" name="LargeIntestine_bc_PortalVein_bc" description="Neighborhood between Large Intestine/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="wMP3kbtQaUKQg4QfYQVYGg" secondNeighbor="UsK_koflU0aP-ubDRlslJQ">
-              <Tags>
-                <Tag value="LargeIntestine_bc_PortalVein_bc" />
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="sHVHssVCIEykaXxmubyi_A" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Transport id="uQ6YnNQZaEyauzB7UowYmg" name="MassTransferLinRBC2BloodPool_Pve" description="Mass transfer from Large Intestine to Portal Vein: Blood Cells" mode="Logical" containerType="Other" dimension="Dimensionless" formula="8BOH4ubnPEmH2eiju97TBA" sourceAmount="BbZT4ZKz3ES0AnolBdIDWw" targetAmount="F8UZepNEFEqiqDVPY4DDnA" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="VseupBP320yIFMC-lWZ_3Q" name="LargeIntestine_pls_PortalVein_pls" description="Neighborhood between Large Intestine/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="kX3NLMXH5kGsPE4c_l2A7A" secondNeighbor="t3RJcRrWZk6Yk-_IRw-vvA">
-              <Tags>
-                <Tag value="LargeIntestine_pls_PortalVein_pls" />
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="CHelOVvfJ0WiNOmyrm_P8g" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Transport id="wtz5ekTtYU6mavOPhrlzwA" name="MassTransferLinPlasma2BloodPool_Pve" description="Mass transfer from Large Intestine :Plasma to Portal Vein: Plasma" mode="Logical" containerType="Other" dimension="Dimensionless" formula="Rg5ORidojESHkodsP7qF2Q" sourceAmount="CeR0DerUEk6Aqx58R2Mk4Q" targetAmount="3epVIeHC_0m65IYsJjSaDQ" />
-                  </Children>
-                </Container>
-              </Children>
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-            <Neighborhood id="jMI31z0zV0qU70zbsT_7zA" name="LargeIntestine_pls_LargeIntestine_int" description="Neighborhood between Large Intestine/Plasma and Large Intestine/Interstitial" mode="Logical" containerType="Other" firstNeighbor="kX3NLMXH5kGsPE4c_l2A7A" secondNeighbor="0MSX5zYlDUGmNmmRt_-66g">
-              <Tags>
-                <Tag value="LargeIntestine_pls_LargeIntestine_int" />
-                <Tag value="Large intestine  neighborhood" />
-                <Tag value="Neighborhood: Plasma / Interstitial" />
-              </Tags>
-              <Children>
-                <Container id="pUQzD35mZ0207nPLgtzyDA" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="XgAi2nijyker4vBHsOoSuA" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" formula="AqWLHo_Y702eTHeCB2zNrQ" dim="Velocity" quantityType="0" />
-                    <Parameter id="Og_nlXHyJUGZV4UPRUTM-w" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" formula="-DEFSC4vn0ajeww6-OP5eg" dim="Dimensionless" quantityType="0" />
-                    <Transport id="E4jc3PQcAkaVzKCUKzuNkw" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Other" dimension="Dimensionless" formula="PIdPzBEYUUmMxBoGOFycnQ" sourceAmount="CeR0DerUEk6Aqx58R2Mk4Q" targetAmount="xfE-lNQYs0u0uNUT0IDWdw" />
-                  </Children>
-                </Container>
-                <Parameter id="Z91Ty87XjES-Lr23PnuDrg" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" formula="x1k7k8iAI0mPTodxjsXY4Q" dim="Surface" quantityType="0" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="5541nVXlOUObSIWw4FlQog" name="LargeIntestine_pls_LargeIntestine_bc" description="Neighborhood between Large Intestine/Plasma and Large Intestine/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="kX3NLMXH5kGsPE4c_l2A7A" secondNeighbor="wMP3kbtQaUKQg4QfYQVYGg">
-              <Tags>
-                <Tag value="LargeIntestine_pls_LargeIntestine_bc" />
-                <Tag value="Large intestine  neighborhood" />
-                <Tag value="Neighborhood: Plasma / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="6CH3lKU70ECl0nAEjljK8Q" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Transport id="eMyxnQdRG0Kjp4E9dVygmw" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Other" dimension="Dimensionless" formula="JvRM3H5280ywTmGcWPrhmQ" sourceAmount="CeR0DerUEk6Aqx58R2Mk4Q" targetAmount="BbZT4ZKz3ES0AnolBdIDWw" />
-                  </Children>
-                </Container>
-                <Parameter id="xsenCd1DG0egvfoNNLPfbg" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" formula="cOILmEqfvkSuoymhnxTWdA" dim="Surface" quantityType="0" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="Jnjxpe2E5kKHD2khPXVLyA" name="LargeIntestine_int_LargeIntestine_cell" description="Neighborhood between Large Intestine/Interstitial and Large Intestine/Intracellular" mode="Logical" containerType="Other" firstNeighbor="0MSX5zYlDUGmNmmRt_-66g" secondNeighbor="iYxcQ6cTuUi76OZcQHLbbg">
-              <Tags>
-                <Tag value="LargeIntestine_int_LargeIntestine_cell" />
-                <Tag value="Large intestine  neighborhood" />
-                <Tag value="Neighborhood: Interstitial / Intracellular" />
-              </Tags>
-              <Children>
-                <Container id="9hm2YBMnRUmRchjUzRMgjQ" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="lkImqfGiTEyIih0z1JNE9A" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="xQZ40Mn0s0Wf7QlpiyG1_w" dim="Velocity" quantityType="0" />
-                    <Parameter id="JWyBL0-dEUakGqQ-R3FwoA" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="3-LEyoK2GEOuCEV2otw_AQ" dim="Velocity" quantityType="0" />
-                    <Parameter id="RZEuNT_A1UyoIQelXKtc5w" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="DIQILkkEz06QbATD24Bttw" dim="Flow (volume)" quantityType="0" />
-                    <Parameter id="Wu9f40uLo0Sqw7GceeLBnA" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="GRkU-raPfUeXS_32oxTzjQ" dim="Flow (volume)" quantityType="0" />
-                    <Parameter id="GV3FM03nFkil5p8tgc3nKA" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="z17Zk_4lm0m0N8biwHITyw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="2gopaKQPQUCUWzGbHoD4Ag" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="tEbBlxSv-0ihTkGf14bbWQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="MN-MtqgC2kq96TAMFGC20g" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" formula="ny90gf988UeCoxjlMH58bg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="3X5FnhhM_UGQvnXtXftT6g" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" formula="3cJBFwQjyUqzb_kQadzpHA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="kkLCaEewLU-VWWO31-tICw" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" formula="2_XVrQuJi0a9xveJ8sbz5g" dim="Dimensionless" quantityType="0" />
-                    <Transport id="N-DvN59txE2BAG_NA2_WuA" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Other" dimension="Dimensionless" formula="4o5waK5k5EupUj818XnypQ" sourceAmount="xfE-lNQYs0u0uNUT0IDWdw" targetAmount="I4gd3Pd1HUGgZcAEqBNrkw" />
-                  </Children>
-                </Container>
-                <Parameter id="yMIAj5ApAkqUgqyYU_3-mw" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" formula="pzLmNLWxNUSaaR-4GEDRAA" dim="Surface" quantityType="0" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="sdkbAQ7EKkCg8Gs0mej-dA" name="Liver_cell_Gallbladder" description="Neighborhood between Liver/Intracellular and Gallbladder" mode="Logical" containerType="Other" firstNeighbor="w6ywNQ_GkUemc_h0o6uyCA" secondNeighbor="uBLlR7CrAkeiLW2yuKLD4g">
-              <Tags>
-                <Tag value="Liver_cell_Gallbladder" />
-                <Tag value="Neighborhood: Intracellular / Gallbladder" />
-              </Tags>
-              <Children>
-                <Container id="yoeOpCP5lEaJogEoHD3vXg" name="Drug" mode="Logical" containerType="Other" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="fQNnBVKBAUyHGxd2xSdNQg" name="Liver_pls_Liver_bc" description="Neighborhood between Liver/Plasma and Liver/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="_sbIJKlDHEqfMsTisyn56A" secondNeighbor="d9wdan-6bEKXeRNfnCMK0g">
-              <Tags>
-                <Tag value="Liver_pls_Liver_bc" />
-                <Tag value="Neighborhood: Plasma / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="bV0UfbF1gE-3YOpD077-kQ" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Transport id="RhM6u0RbDkKcpGQdOQVXVA" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Other" dimension="Dimensionless" formula="kc0EzE3J6Uu5ZNRVkj3OwA" sourceAmount="3EA1OLywM0SY7jEyMKI0Hw" targetAmount="Ka94IY55pkyxs6zgBn7D9g" />
-                  </Children>
-                </Container>
-                <Parameter id="JgU84o45RE-IXJfR5IKFZQ" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" formula="EYRXsONfKUSAtRwLJIGgxA" dim="Surface" quantityType="0" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="6pc950sOckyYIpDTjvZ3ag" name="Liver_bc_VenousBlood_bc" description="Neighborhood between Liver/Blood Cells and Venous Blood/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="d9wdan-6bEKXeRNfnCMK0g" secondNeighbor="vv8rxyxvYkasBnpcCaOSyg">
-              <Tags>
-                <Tag value="Liver_bc_VenousBlood_bc" />
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="4J0CbdfO8E2DLJbzeTEqwQ" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Transport id="NaRkt-tvoU6h68oDnNlRag" name="MassTransferOrgRBC2BloodPool_Liv" description="Mass transfer from Liver: Blood Cells to Venous Blood: Blood Cells" mode="Logical" containerType="Other" dimension="Dimensionless" formula="T7eh2LRNckmleA-BX9XjkQ" sourceAmount="Ka94IY55pkyxs6zgBn7D9g" targetAmount="FMF6RMb5pkyvcn1PXHNkgw" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="Ox96tn3ynEm0_aDZXWZ5Bg" name="Liver_pls_Liver_int" description="Neighborhood between Liver/Plasma and Liver/Interstitial" mode="Logical" containerType="Other" firstNeighbor="_sbIJKlDHEqfMsTisyn56A" secondNeighbor="44VqNxVA40SVe6agWBprfg">
-              <Tags>
-                <Tag value="Liver_pls_Liver_int" />
-                <Tag value="Neighborhood: Plasma / Interstitial" />
-              </Tags>
-              <Children>
-                <Container id="1pVXjRBx6EmG4ZHRRWMoXg" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="62aY8KiaV0CyWOy0WrjuaA" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" formula="-DEFSC4vn0ajeww6-OP5eg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="5SzdjfpFKEeCF1FyZTeJ5g" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" formula="jmghPEyh-0GKHlkdy5T3gw" dim="Velocity" quantityType="0" />
-                    <Transport id="bP7F6Ue_8EeE5UaVUZgGSg" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Other" dimension="Dimensionless" formula="tuM4a1VU9Emb5dojG0ErLA" sourceAmount="3EA1OLywM0SY7jEyMKI0Hw" targetAmount="OS3dPN2ioUidstWIZgpXQA" />
-                  </Children>
-                </Container>
-                <Parameter id="7Ilv7TtzKUuZdgfPkWbeZA" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" formula="tdT1-bs5G0e9LA2H-YbrMQ" dim="Surface" quantityType="0" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="JXS2T9hgVE-8yBNq2V4xKg" name="Liver_pls_VenousBlood_pls" description="Neighborhood between Liver/Plasma and Venous Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="_sbIJKlDHEqfMsTisyn56A" secondNeighbor="R5jgBt3okEeUHClw7hT2EA">
-              <Tags>
-                <Tag value="Liver_pls_VenousBlood_pls" />
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="cYz-l7iKNEG-8uRbAn_uSg" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Transport id="7x8Dya1jN0uY3KSw6QHDSA" name="MassTransferOrgPl2BloodPool_Liv" description="Mass transfer from Liver: Plasma to Venous Blood: Plasma" mode="Logical" containerType="Other" dimension="Dimensionless" formula="D2G5cK64mUaArlKp4GWQGw" sourceAmount="3EA1OLywM0SY7jEyMKI0Hw" targetAmount="0z8uD-0gmE61mkI_fDKAZQ" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="BiAL9iKq-UuXokHXD7RR6w" name="Liver_int_Liver_cell" description="Neighborhood between Liver/Interstitial and Liver/Intracellular" mode="Logical" containerType="Other" firstNeighbor="44VqNxVA40SVe6agWBprfg" secondNeighbor="w6ywNQ_GkUemc_h0o6uyCA">
-              <Tags>
-                <Tag value="Liver_int_Liver_cell" />
-                <Tag value="Neighborhood: Interstitial / Intracellular" />
-              </Tags>
-              <Children>
-                <Container id="APq24AnZOU6L_t6EWm-OBQ" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="UmXgPosDsEaJ3kRHZRumyQ" name="Min (PA, Q)" description="Minimum between permeability and blood flow" persistable="0" isFixedValue="0" formula="xqvn0_vSK0695FJ36DRTDw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="3wvnUOBdlU-U_tKHZnPxGw" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="xQZ40Mn0s0Wf7QlpiyG1_w" dim="Velocity" quantityType="0" />
-                    <Parameter id="Gr0aUjmrPEuV6S0iFQZaog" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="3-LEyoK2GEOuCEV2otw_AQ" dim="Velocity" quantityType="0" />
-                    <Parameter id="3R0pNB8wqkOa_OQ9_bWOxA" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="DIQILkkEz06QbATD24Bttw" dim="Flow (volume)" quantityType="0" />
-                    <Parameter id="Bo1geZuoYEKDVvM1fUppYA" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="GRkU-raPfUeXS_32oxTzjQ" dim="Flow (volume)" quantityType="0" />
-                    <Parameter id="atN9NwY_e0idhz1G5PX64Q" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="W7B8ULUCGEidZUtH7A8r_Q" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="zBO3RerwxUyVSAjJL1YQOA" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="YM5xYPW3h0CCHZe9hyiPXQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="MZTTpbk3p0y_8EIeqWPTqA" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" formula="DqaLb0MOnE6ivJiTGzLNaQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="C2Zuh2-n5UCWdRWHqfGZLg" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" formula="3cJBFwQjyUqzb_kQadzpHA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="U5WXWthO7EC-LlGr_er8Vw" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" formula="0aOqBRRqJESh0bit6iCG2w" dim="Dimensionless" quantityType="0" />
-                    <Transport id="5xvPgmkDqUOd523ro4v-8Q" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Other" dimension="Dimensionless" formula="UI4IbHdjz0yxchoFJN4X6g" sourceAmount="OS3dPN2ioUidstWIZgpXQA" targetAmount="danwiYvRrEOmB-ioVuNjmA" />
-                  </Children>
-                </Container>
-                <Parameter id="AoqSGFPsr0-U9yeK264ffA" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" formula="zUcIRBP7Xkyvs0QSBjpq0g" dim="Surface" quantityType="0" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="89nAxqX760WRFkAzL6ZvYw" name="Gallbladder_Lumen_duo" description="Gallbladder and Lumen/Duodenum" mode="Logical" containerType="Other" firstNeighbor="uBLlR7CrAkeiLW2yuKLD4g" secondNeighbor="lZLwaVLayEa1f_nNQ00DVQ">
-              <Tags>
-                <Tag value="Gallbladder_Lumen_duo" />
-                <Tag value="Neighborhood: Gallbladder / Duodenum" />
-              </Tags>
-              <Children>
-                <Container id="oAFT7dPI6k2-77QQ-C4LFA" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Transport id="ISXWfVU2JkCUQgH5dDopSQ" name="GallbladderEmptying" description="Gallbladder emptying" mode="Logical" containerType="Other" dimension="Dimensionless" formula="vkDjJWsaE0yLRXfrCC6xaQ" sourceAmount="bC6OL3OSKECC8fraNnuVyw" targetAmount="Cp9CcV7Ov06YVtSbGuudTw" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="-u5z53odPU6zfUIDvyqiMg" name="Liver_cell_Lumen_duo" description="Neighborhood between Liver/Intracellular and Lumen/Duodenum" mode="Logical" containerType="Other" firstNeighbor="w6ywNQ_GkUemc_h0o6uyCA" secondNeighbor="lZLwaVLayEa1f_nNQ00DVQ">
-              <Tags>
-                <Tag value="Liver_cell_Lumen_duo" />
-                <Tag value="Neighborhood: Intracellular / Duodenum" />
-              </Tags>
-              <Children>
-                <Container id="sqpgEvKg_ECMRltGXphumg" name="Drug" mode="Logical" containerType="Other" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="Jag0tK-5G0ukG4y_CPwT8Q" name="Lung_bc_ArterialBlood_bc" description="Neighborhood between Lung/Blood Cells and Arterial Blood/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="s85_Z4kn80SxcALgg648Zg" secondNeighbor="yHKVfLHCj02vJfFqJ_50sQ">
-              <Tags>
-                <Tag value="Lung_bc_ArterialBlood_bc" />
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="nuRxX-XgiEGF4r9HS57atg" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Transport id="ddewfQUGfUuO7KAicdiTDw" name="MassTransferOrgRBC2BloodPool_Lng" description="Mass transfer from Lung: Blood Cells to Arterial Blood: Blood Cells" mode="Logical" containerType="Other" dimension="Dimensionless" formula="i8jVF1EfF0KLmnGKXIiHyA" sourceAmount="PjBa80ZcpUas6y-m_9W8HA" targetAmount="KoF_gPV3a0C8KDxsooKTTQ" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="9KHMTN8W4ka5dpwvChDJeA" name="Lung_pls_ArterialBlood_pls" description="Neighborhood between Lung/Plasma and Arterial Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="y37Pbm_v8kq2DDBtieuQ_w" secondNeighbor="p_fPz7AdjkmBeY1cPby9Qw">
-              <Tags>
-                <Tag value="Lung_pls_ArterialBlood_pls" />
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="vUwN3p7aa0yS7C37Hz6icw" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Transport id="Nepufbh6zkGUaQZDpcDxvw" name="MassTransferOrgPl2BloodPool_Lng" description="Mass transfer from Lung: Plasma to Arterial Blood: Plasma" mode="Logical" containerType="Other" dimension="Dimensionless" formula="2JskqZdRwUKoeR_IzMMfsg" sourceAmount="w1ZFXYWXKkaN0StkX-XcEg" targetAmount="-KHwz6KsaUKMJrU3wcwlsw" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="c9EKImRNU0KJ89-389AJTg" name="Lung_pls_Lung_bc" description="Neighborhood between Lung/Plasma and Lung/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="y37Pbm_v8kq2DDBtieuQ_w" secondNeighbor="s85_Z4kn80SxcALgg648Zg">
-              <Tags>
-                <Tag value="Lung_pls_Lung_bc" />
-                <Tag value="Neighborhood: Plasma / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="mfEjoMSO8UG9NXltcEpisg" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Transport id="qsTfSbvBQU-5KzRnLWMr_Q" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Other" dimension="Dimensionless" formula="5iPuGzXyeUGwP0jozHBhsw" sourceAmount="w1ZFXYWXKkaN0StkX-XcEg" targetAmount="PjBa80ZcpUas6y-m_9W8HA" />
-                  </Children>
-                </Container>
-                <Parameter id="Xmk6KwH5rk6fb6fIbz7tqA" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" formula="xglb91FIak6Tmdvuk9FgGA" dim="Surface" quantityType="0" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="4D5hEfXwhUqQMzwIbQbnpw" name="Lung_pls_Lung_int" description="Neighborhood between Lung/Plasma and Lung/Interstitial" mode="Logical" containerType="Other" firstNeighbor="y37Pbm_v8kq2DDBtieuQ_w" secondNeighbor="HGcrBCIpU0O8ZlFThRwjmA">
-              <Tags>
-                <Tag value="Lung_pls_Lung_int" />
-                <Tag value="Neighborhood: Plasma / Interstitial" />
-              </Tags>
-              <Children>
-                <Container id="hhBv5Oei2kiFr0nJaRE3Qw" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="Q5n8lEJ_-0-XG4i1b1MeCg" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" formula="1wu5QrBPt0uH1m0lSPxoFQ" dim="Velocity" quantityType="0" />
-                    <Parameter id="LL0cXM9u3ESV43WwUUHPSg" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" formula="-DEFSC4vn0ajeww6-OP5eg" dim="Dimensionless" quantityType="0" />
-                    <Transport id="mjNhnAFc70K_nEVccpJtmQ" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Other" dimension="Dimensionless" formula="p89f7XEf7Uac6Wkp706x4w" sourceAmount="w1ZFXYWXKkaN0StkX-XcEg" targetAmount="70aiKKv9ZkyhcArSCq7NiA" />
-                  </Children>
-                </Container>
-                <Parameter id="j-EeOTyjlkO8y9PmxjmYaQ" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" formula="dDIx8unUwkWICmTV0kBq0Q" dim="Surface" quantityType="0" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="zg3owGV-eEiysOSqfTAyAg" name="Lung_int_Lung_cell" description="Neighborhood between Lung/Interstitial and Lung/Intracellular" mode="Logical" containerType="Other" firstNeighbor="HGcrBCIpU0O8ZlFThRwjmA" secondNeighbor="xNhU-Z9yvUGm1ObELEg1Sw">
-              <Tags>
-                <Tag value="Lung_int_Lung_cell" />
-                <Tag value="Neighborhood: Interstitial / Intracellular" />
-              </Tags>
-              <Children>
-                <Container id="kb6e5qHL3kW3Ll67HhoIjg" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="JKPEkjfr5UmvkGjLIFQ1hA" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="fVd-CnXi_UC1VOTiR9S-Uw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="PaL7KI0inE2PssI86EGvWA" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="Lhiv1z-s40CuPIosngmZWw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="4AQ6ch5R6EmvIFZwRZAW7w" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" formula="N79QuFAWAEeZk56q3juIOA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="1U2tUvqikkast-PSDEE2_g" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" formula="3cJBFwQjyUqzb_kQadzpHA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="Qrk5a8X3_UqVC-m527br-w" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="3-LEyoK2GEOuCEV2otw_AQ" dim="Velocity" quantityType="0" />
-                    <Parameter id="VPqYG_gmwkqEfH1rn_ChFA" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="GRkU-raPfUeXS_32oxTzjQ" dim="Flow (volume)" quantityType="0" />
-                    <Parameter id="JrKALKM3LEuHnaQwcx1ewQ" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="DIQILkkEz06QbATD24Bttw" dim="Flow (volume)" quantityType="0" />
-                    <Parameter id="Tp76Z8F6WU2Viepe3lGxSw" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="xQZ40Mn0s0Wf7QlpiyG1_w" dim="Velocity" quantityType="0" />
-                    <Parameter id="WWwDPN0OIUOa3X3tqwjBew" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" formula="O7i8LqCH5UmcTOJVaQUagg" dim="Dimensionless" quantityType="0" />
-                    <Transport id="bTJH0aaOJUqnlj4gAtW5sw" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Other" dimension="Dimensionless" formula="71qtbYqovkChfZ32WVogGg" sourceAmount="70aiKKv9ZkyhcArSCq7NiA" targetAmount="9daj-QIUfUumAKkzRuANLg" />
-                  </Children>
-                </Container>
-                <Parameter id="jufDTK3rvkiV6Jclsd2m-Q" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" formula="TkGHj4vSxE2NQWhOp2yRHw" dim="Surface" quantityType="0" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="ok0CbLGNKEi4GPTL6tZswA" name="Muscle_int_Muscle_cell" description="Neighborhood between Muscle/Interstitial and Muscle/Intracellular" mode="Logical" containerType="Other" firstNeighbor="QBBX9qe4D0aZZ01O2aaTgA" secondNeighbor="TtOc9YUjEkOFo-RzolSs2g">
-              <Tags>
-                <Tag value="Muscle_int_Muscle_cell" />
-                <Tag value="Neighborhood: Interstitial / Intracellular" />
-              </Tags>
-              <Children>
-                <Container id="HrUn5p74TkqZ55AbXnK9xg" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="v6U7UGJ3Y0-psPhGlVUyjg" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="XfveYeSSW0WcaxrwJBXXgA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="2Qemdbml-Uubtc8k53sF0w" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="xQZ40Mn0s0Wf7QlpiyG1_w" dim="Velocity" quantityType="0" />
-                    <Parameter id="1TfMQePzjkWKyOxJdmHaYA" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="3-LEyoK2GEOuCEV2otw_AQ" dim="Velocity" quantityType="0" />
-                    <Parameter id="snGGWyvb3EWvV6TMxz_F0A" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="DIQILkkEz06QbATD24Bttw" dim="Flow (volume)" quantityType="0" />
-                    <Parameter id="Caq8bDpwW0-psdb9kVsIJw" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="uCxjDXSOpkSrQgi9_N8dhQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="_vsuccrlfEqyedJVw9UQNg" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="GRkU-raPfUeXS_32oxTzjQ" dim="Flow (volume)" quantityType="0" />
-                    <Parameter id="7U5rgTFp2Eal_C5aU666WA" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" formula="gqAjBCyHG0GI0tWFCoXbUw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="_1jbkReqDUypHgRj2zu_JQ" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" formula="3cJBFwQjyUqzb_kQadzpHA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="R3P_kjYJmEaplKrJDrxfTQ" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" formula="E514TjSxHEmEerQ8H0iYzQ" dim="Dimensionless" quantityType="0" />
-                    <Transport id="keRABWUY1ke_aOy3uccZ5g" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Other" dimension="Dimensionless" formula="3QyuHKAvtE2GnpBjSVjpMQ" sourceAmount="Vc1nUmQ3mEKNxqUn3aFybg" targetAmount="4sHoPdMFYUKpIuxmRIUXMQ" />
-                  </Children>
-                </Container>
-                <Parameter id="8V5xF-6RgkqmRij86NHvvQ" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" formula="yRezTyL1m0CS-xNqNNgcow" dim="Surface" quantityType="0" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="EufQmQ2e9UOVG0tV2BGOZA" name="Muscle_pls_Muscle_bc" description="Neighborhood between Muscle/Plasma and Muscle/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="j_JrVItAVU6EpRUdZbl0UA" secondNeighbor="20iaSAYZ7U64zlOpve5r9A">
-              <Tags>
-                <Tag value="Muscle_pls_Muscle_bc" />
-                <Tag value="Neighborhood: Plasma / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="1IgV6PT3602eXh7XstcPGQ" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Transport id="PrYFZ-IHF029LPUBFobn-A" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Other" dimension="Dimensionless" formula="TkoQNdz6dkGdeB5y8YAUUQ" sourceAmount="FRsQYyohb0WQw49_fjEwMA" targetAmount="XVzDPQHe_UajzR6Os5RQ9g" />
-                  </Children>
-                </Container>
-                <Parameter id="N7OJzfINyUedqrxFa0GGYQ" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" formula="j-ATKOpp20Khue3AEYVgwQ" dim="Surface" quantityType="0" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="MUaHyvwsvUiWJnYIPxbFTw" name="Muscle_pls_VenousBlood_pls" description="Neighborhood between Muscle/Plasma and Venous Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="j_JrVItAVU6EpRUdZbl0UA" secondNeighbor="R5jgBt3okEeUHClw7hT2EA">
-              <Tags>
-                <Tag value="Muscle_pls_VenousBlood_pls" />
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="NJo2C13du0GVcSMWv1uvlw" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Transport id="9S_Ig6IuD060sFWWI3JYUg" name="MassTransferOrgPl2BloodPool" description="Mass transfer from organ: Plasma to Venous Blood: Plasma" mode="Logical" containerType="Other" dimension="Dimensionless" formula="709sryLQjEOUuiHUfOcJng" sourceAmount="FRsQYyohb0WQw49_fjEwMA" targetAmount="0z8uD-0gmE61mkI_fDKAZQ" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="GXnYaxCkWki38Gq8gnM2ng" name="Muscle_pls_Muscle_int" description="Neighborhood between Muscle/Plasma and Muscle/Interstitial" mode="Logical" containerType="Other" firstNeighbor="j_JrVItAVU6EpRUdZbl0UA" secondNeighbor="QBBX9qe4D0aZZ01O2aaTgA">
-              <Tags>
-                <Tag value="Muscle_pls_Muscle_int" />
-                <Tag value="Neighborhood: Plasma / Interstitial" />
-              </Tags>
-              <Children>
-                <Container id="0IPt5_XrOEqhgx1IdX2jUw" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="lWIeT-8xtUeTuQaDtpwIOg" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" formula="G_o3Oh9eoEydQAFHxGXlCQ" dim="Velocity" quantityType="0" />
-                    <Parameter id="TYqK1VhWTki6CObfEtYkbA" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" formula="-DEFSC4vn0ajeww6-OP5eg" dim="Dimensionless" quantityType="0" />
-                    <Transport id="in5O_N4E10-rObG7ARgnJA" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Other" dimension="Dimensionless" formula="jchUy1D0r0-t8ojMf_vMLA" sourceAmount="FRsQYyohb0WQw49_fjEwMA" targetAmount="Vc1nUmQ3mEKNxqUn3aFybg" />
-                  </Children>
-                </Container>
-                <Parameter id="tkyzwVol5E2c1OWUfmK6mA" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" formula="gwBGZ7Nhe0m9m-7HAnelig" dim="Surface" quantityType="0" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="kCDotSl3tE26L3sSVY2bkw" name="Muscle_bc_VenousBlood_bc" description="Neighborhood between Muscle/Blood Cells and Venous Blood/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="20iaSAYZ7U64zlOpve5r9A" secondNeighbor="vv8rxyxvYkasBnpcCaOSyg">
-              <Tags>
-                <Tag value="Muscle_bc_VenousBlood_bc" />
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="n9WrBI04z0ujr7Ji17wceA" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Transport id="5pK5f8Qg2k2hYMxG_lBykA" name="MassTransferOrgRBC2BloodPool" description="Mass transfer from organ: Blood Cells to Arterial Blood: Blood Cells" mode="Logical" containerType="Other" dimension="Dimensionless" formula="y3562XGpqkuKm9OfKvTnzQ" sourceAmount="XVzDPQHe_UajzR6Os5RQ9g" targetAmount="FMF6RMb5pkyvcn1PXHNkgw" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="Rsz49PMULESawWtZcx6-hQ" name="Pancreas_bc_PortalVein_bc" description="Neighborhood between Pancreas/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="bC2pK9qHBUKn8mZbyhrQUA" secondNeighbor="UsK_koflU0aP-ubDRlslJQ">
-              <Tags>
-                <Tag value="Pancreas_bc_PortalVein_bc" />
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="kj2tVGx8C0GIYzE4RwVjew" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Transport id="rkeDXlBB60eAUhvinDtdQQ" name="MassTransferOrgRBC2BloodPool_Pve" description="Mass transfer from organ: Blood Cells to Portal Vein: Blood Cells" mode="Logical" containerType="Other" dimension="Dimensionless" formula="8wJ-Yi5HVEKgZ0SWlPXdwQ" sourceAmount="9968Lq-A-0-c-nNV7nhWCA" targetAmount="F8UZepNEFEqiqDVPY4DDnA" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="OQKA68inOkak_34uAVJNNw" name="Pancreas_pls_PortalVein_pls" description="Neighborhood between Pancreas/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="PPDj7eTW0EWOYgdN7qEVYQ" secondNeighbor="t3RJcRrWZk6Yk-_IRw-vvA">
-              <Tags>
-                <Tag value="Pancreas_pls_PortalVein_pls" />
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="zYsMVRYEd0mR-NTTYCmu8g" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Transport id="l6enNX2YYk2xgvn8zDLGBQ" name="MassTransferOrgPl2BloodPool_pve" description="Mass transfer from organ: Plasma to Portal Vein: Plasma" mode="Logical" containerType="Other" dimension="Dimensionless" formula="PqyhmYBpBEKTtBiqVEM2zA" sourceAmount="3-mvjTkkBky2YGOmhNBhsA" targetAmount="3epVIeHC_0m65IYsJjSaDQ" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="Lvy_UlI8hUuu8gNbwzcV6g" name="Pancreas_pls_Pancreas_int" description="Neighborhood between Pancreas/Plasma and Pancreas/Interstitial" mode="Logical" containerType="Other" firstNeighbor="PPDj7eTW0EWOYgdN7qEVYQ" secondNeighbor="6daBVrW74EuTLCr7V8QeJQ">
-              <Tags>
-                <Tag value="Pancreas_pls_Pancreas_int" />
-                <Tag value="Neighborhood: Plasma / Interstitial" />
-              </Tags>
-              <Children>
-                <Container id="2qryv1Q1MU-iNE9yGxLpDQ" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="Tyy-Zkgz80Kvq_R-4g8k0g" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" formula="U2eVTxRB0E63kkFytv2xBw" dim="Velocity" quantityType="0" />
-                    <Parameter id="Ts1xfuPK50K-7vfAIizWOA" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" formula="-DEFSC4vn0ajeww6-OP5eg" dim="Dimensionless" quantityType="0" />
-                    <Transport id="olQeH5QR6U2emlC1_pbmjQ" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Other" dimension="Dimensionless" formula="R4ll1623rk2GCkwwvGNIkg" sourceAmount="3-mvjTkkBky2YGOmhNBhsA" targetAmount="SsiNokEHRkSQiH-hD0HtkQ" />
-                  </Children>
-                </Container>
-                <Parameter id="HkJSt11HWUGIkNPw1AMrHQ" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" formula="4Qr4ybESNUGbXnxgME83fg" dim="Surface" quantityType="0" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="mzZhcje9nEaB2Ss0l3DtEA" name="Pancreas_pls_Pancreas_bc" description="Neighborhood between Pancreas/Plasma and Pancreas/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="PPDj7eTW0EWOYgdN7qEVYQ" secondNeighbor="bC2pK9qHBUKn8mZbyhrQUA">
-              <Tags>
-                <Tag value="Pancreas_pls_Pancreas_bc" />
-                <Tag value="Neighborhood: Plasma / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="ZSmLyyuINEyXs6Y8NOvuRA" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Transport id="0YY7eunoDUyN89EfwOYk1A" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Other" dimension="Dimensionless" formula="66PQ2DjJCkuIueXSJkiDrg" sourceAmount="3-mvjTkkBky2YGOmhNBhsA" targetAmount="9968Lq-A-0-c-nNV7nhWCA" />
-                  </Children>
-                </Container>
-                <Parameter id="iCGJBLZPLE2kh2zGiK02Vg" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" formula="LSkha98uKUaBycHsHsN3NQ" dim="Surface" quantityType="0" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="lBfj1WHtWkKCFY-AUSyIhw" name="Pancreas_int_Pancreas_cell" description="Neighborhood between Pancreas/Interstitial and Pancreas/Intracellular" mode="Logical" containerType="Other" firstNeighbor="6daBVrW74EuTLCr7V8QeJQ" secondNeighbor="-1NfSd9xsEipf-8e4l6OnA">
-              <Tags>
-                <Tag value="Pancreas_int_Pancreas_cell" />
-                <Tag value="Neighborhood: Interstitial / Intracellular" />
-              </Tags>
-              <Children>
-                <Container id="CDqXsmjOfUSq5bjRyxHRZg" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="O6L4IfVSe06qWQ4nrQHhMQ" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" formula="D2ClsfwGLEq4cq3Fq2J9Cw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="yiavP8orh0ezXrVWXgexFw" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" formula="3cJBFwQjyUqzb_kQadzpHA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="A1dhKSE9h0eB137K64TjgA" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="xQZ40Mn0s0Wf7QlpiyG1_w" dim="Velocity" quantityType="0" />
-                    <Parameter id="xJKcVxsuHEW1soayM2TeMw" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="3-LEyoK2GEOuCEV2otw_AQ" dim="Velocity" quantityType="0" />
-                    <Parameter id="Z-f_8cFx9EiXF3GR8JpGrg" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="DIQILkkEz06QbATD24Bttw" dim="Flow (volume)" quantityType="0" />
-                    <Parameter id="mU-yvqSKrUy6c68qp6IEJw" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="GRkU-raPfUeXS_32oxTzjQ" dim="Flow (volume)" quantityType="0" />
-                    <Parameter id="XvnGO6_h5kGhoR9-Wjt9kA" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="T5WYRhx1RUq_4WhG8dJhFA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="DYvvJfsegE-HDDLtjs_YHg" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="AxjgvhfmQUeDYTOVaQgFAw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="YZ9KV2qxRkuUGeYdqgER1Q" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" formula="arcQGL87S0-qiJ1zMP6MjQ" dim="Dimensionless" quantityType="0" />
-                    <Transport id="QUM2FP9Nt06jy7s4dbLq8w" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Other" dimension="Dimensionless" formula="zEPH7fIQaU6SYsjX23VpBw" sourceAmount="SsiNokEHRkSQiH-hD0HtkQ" targetAmount="9vVOn5yMKk2EdQJteuwszg" />
-                  </Children>
-                </Container>
-                <Parameter id="V_H-KsQW50OU8nTW9HpEHQ" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" formula="-mWgOQH0-EaILScYWshs4g" dim="Surface" quantityType="0" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="AqmaEDHCOEqIN6AR9rF1JQ" name="Lumen_rect_Rectum_cell" description="Neighborhood between Lumen/Rectum and Mucosa/Rectum/Intracellular" mode="Logical" containerType="Other" firstNeighbor="OMeI603lPki93VUfJyqQow" secondNeighbor="HFtHaV0v7kCC7nIjLb3r1w">
-              <Tags>
-                <Tag value="Lumen_rect_Rectum_cell" />
-                <Tag value="Neighborhood: Rectum / Intracellular" />
-              </Tags>
-              <Children>
-                <Container id="iQCO3HLEgkCNhBMn_8t6vg" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="_FnJERSAykWtP9EhC-lzQg" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="PWrEDGMP-keah5d9gXafDQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="nbYW5qO8yEiDULLJQIxIFg" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="aJba9lRteUSyHr8r46GXyw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="Mew5wBl54EC8Xa86EoEYXA" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="3uQ_8bks5kSiesc_SOfNwA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="ONQgwyewKkCLg0M5Yc6iBA" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="k8hWpEIpF0KjTAC5NbdvbA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="rm8nE2U2QkCmXTEsRxAnOw" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="SzK_8omVIE-vZmY_eihelA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="y38VAEI57E-53wGeJcHfyA" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="Aw8vq5KCWEOCAoMQrVN6FQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="SjaP-My8Z0CTjfsLCxSvaQ" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="PdH_puI8x0SM-tI3E7CmgQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="ltNFJUghzkuHDqiVHLur1Q" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="aMN4XH4f10CaDLbJlRvOYg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="nQ7sQNsTP0-Octbaqb3RLg" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="my3tTUru8k-_e043IJXzgQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="OvMzED5Qa0iJMcex0EEtJg" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="zBp2kSmApkOM_qzM25bDbg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="1X_MmwMBGE61SSEvnc3LAw" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="AkRbpFWVBEe9u5MbHZxalg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="CM8dyySH_02dJDkDneiVpg" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="Kf9Bxa2_b0Geq1rJPr-UGQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="2a-ISnRA0EiT6wtThWE7GA" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="F6FIReabwUqeLEL5fA8UaA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="8sMOpbRBmE2qNUgbp19ycw" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="QWN9mrAel0-mdjkWIwyAtw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="MCJ22pVaeEiwRQ-Zl83a0A" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="AAnDqAX9zUqoNDW37i4yBQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="OQtWb8L5D0ieskyiU2-QDQ" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="WFbKuaD2_Uut_BXIFvFxpA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="VpotRc9ndE-xtdbOwe5G8Q" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="xM7lqQL_aEy-cELqFKBf3w" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="iuc9Kt5OHUGo8T1JFUUsNA" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="S_qjrFFhlUei9mGuxmLKJg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="hXgGunZq90iTlXS-1Pt8wg" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="_oXVjFXhhUeCaJbmVUbcXQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="_5_hhKheLUyNLtzprdOcjw" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="cNM68S---0qpth-NJcbR_A" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="VZy7ajTExUaidFEwfaO26A" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="K84CtVSsOk6WLUKOacBoaA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="bh44g-_Re0eQ9DwZ6GB9kA" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="q3UCyneZi0CZtpN2SylR9A" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="Q_VvE3uXVkKvlDdr2nf1Fg" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="S5rOyojRIUmpgOV6TPakRQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="pBj64DpxPkiyht-FHWadPw" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" formula="Pjqb6HcD9Ea9WZg6f31rag" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="UlvL5pm-zUOssPrx137eOg" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="RJRIddynfU-kStoSCNdNxQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="kzlyt14ipkC_V1j64TwS0Q" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" formula="sOrwOpIF_EWIpRcYRt_YIw" dim="Rate" quantityType="0" />
-                    <Parameter id="ubqk7ZXCcUWr0GSX98dTIA" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" formula="9kqJbWXsb0WZ5Y4HIZpNOQ" dim="Dimensionless" quantityType="0" />
-                    <Transport id="NcVLy-TaPkmEp81J88eQMA" name="DrugAbsorption_trans" description="Drug absorption transcellular" mode="Logical" containerType="Other" dimension="Dimensionless" formula="jnVVDLuQ70uby6m0eBVYGg" sourceAmount="2jgxGdCNzUeUlFBm086prw" targetAmount="Q-WHhoDEmkCqkRQKuB9hMQ" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="W2qCPgFywUaupOq-wMdRDQ" name="Rectum_bc_PortalVein_bc" description="Neighborhood between Rectum/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="MFTNPY8lYUuHI3TkYqAe_Q" secondNeighbor="UsK_koflU0aP-ubDRlslJQ">
-              <Tags>
-                <Tag value="Rectum_bc_PortalVein_bc" />
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="zN9-kByemEGhqtvnb_SPVA" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="5IXiD_vuFUCYYWsmYCpTtQ" name="Mass transfer rate (mucosa to portal vein blood cells)" description="Mass transfer rate (mucosa to portal vein blood cells)" persistable="0" isFixedValue="0" formula="g_xJukQBtUS95UJ2fN3NlQ" dim="Rate" quantityType="0" />
-                    <Transport id="HBRukOYl00qzHKvJ1j14Vw" name="MassTransferMucosaToPveBC" description="Mass transfer from Mucosa:Blood Cells To Portal Vein: Blood Cells" mode="Logical" containerType="Other" dimension="Dimensionless" formula="erz-UsLpxkquw1QWFNZI3Q" sourceAmount="bw0eSCTFWkiTM1Eimt2DBQ" targetAmount="F8UZepNEFEqiqDVPY4DDnA" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="dvsFPZUC5E2Z2un2j4gEJA" name="Rectum_pls_PortalVein_pls" description="Neighborhood between Rectum/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="zhw7k9aVu0eeZFACLC99xw" secondNeighbor="t3RJcRrWZk6Yk-_IRw-vvA">
-              <Tags>
-                <Tag value="Rectum_pls_PortalVein_pls" />
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="vff9M3FqiEi4pmzsUMHoiQ" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="GUws9--hBESrZNZnsU_FPA" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" persistable="0" isFixedValue="0" formula="NnPjiFy8GU2HzF-1NqdmCw" dim="Rate" quantityType="0" />
-                    <Transport id="_4wLW3FkxEmFdNqRGRiHjA" name="MassTransferMucosaToPvePlasma" description="Mass transfer from Mucosa:Plasma To Portal Vein: Plasma" mode="Logical" containerType="Other" dimension="Dimensionless" formula="7xa4C9sDn0ifu5K7_xoOAg" sourceAmount="r7ItQnvBJ0efZqobBY36mQ" targetAmount="3epVIeHC_0m65IYsJjSaDQ" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="i6uNWhx50kajd-5RQPXThw" name="Lumen_rect_Rectum_pls" description="Neighborhood between Lumen/Rectum and Mucosa/Rectum/Plasma" mode="Logical" containerType="Other" firstNeighbor="OMeI603lPki93VUfJyqQow" secondNeighbor="zhw7k9aVu0eeZFACLC99xw">
-              <Tags>
-                <Tag value="Lumen_rect_Rectum_pls" />
-                <Tag value="Neighborhood: Rectum / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="x5GdtPqAl0yaPwU7EUJRjA" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="QnsiTPrvpkS_9PYDKYm2pQ" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" formula="JNYW65WLbk-wVjdV1kMbWA" dim="Rate" quantityType="0" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="gO9dfa4JakWsMRXB5wOzIQ" name="PortalVein_pls_PortalVein_bc" description="Neighborhood between PortalVein/Plasma and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="t3RJcRrWZk6Yk-_IRw-vvA" secondNeighbor="UsK_koflU0aP-ubDRlslJQ">
-              <Tags>
-                <Tag value="PortalVein_pls_PortalVein_bc" />
-                <Tag value="Neighborhood: Plasma / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="EM4D6e0g70We1DeoUg8xxQ" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Transport id="WJKw9LO7ikWoA5k_KOBmCg" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Other" dimension="Dimensionless" formula="u2nQGHwCwEOARK6ReCdyZA" sourceAmount="3epVIeHC_0m65IYsJjSaDQ" targetAmount="F8UZepNEFEqiqDVPY4DDnA" />
-                  </Children>
-                </Container>
-                <Parameter id="yMx3VRTLTE-bNCdQ-czIbg" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" formula="C1tLvzra5kKojnzH8_beaA" dim="Surface" quantityType="0" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="i0B3zYdA6U-hwHOMZ3g7ww" name="PortalVein_bc_Liver_bc" description="Neighborhood between PortalVein/Blood Cells and Liver/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="UsK_koflU0aP-ubDRlslJQ" secondNeighbor="d9wdan-6bEKXeRNfnCMK0g">
-              <Tags>
-                <Tag value="PortalVein_bc_Liver_bc" />
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="NhYiSwUMzUCiDGhktojtzw" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Transport id="U5UO9Ipm20CwdeMxddytug" name="MassTransferBloodPool2OrgRBC_liv" description="Mass transfer from Portal Vein: Blood Cells to Liver: Blood Cells" mode="Logical" containerType="Other" dimension="Dimensionless" formula="D6VpkeCMJECX0WzC6PKLyA" sourceAmount="F8UZepNEFEqiqDVPY4DDnA" targetAmount="Ka94IY55pkyxs6zgBn7D9g" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="b17YFOEEhkOlxWvVUM4iqA" name="PortalVein_pls_Liver_pls" description="Neighborhood between PortalVein/Plasma and Liver/Plasma" mode="Logical" containerType="Other" firstNeighbor="t3RJcRrWZk6Yk-_IRw-vvA" secondNeighbor="_sbIJKlDHEqfMsTisyn56A">
-              <Tags>
-                <Tag value="PortalVein_pls_Liver_pls" />
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="ALJwfH_Ia02S4BN--0At0w" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Transport id="SjISmcqR-U6yN0CHz6Z6hA" name="MassTransferBloodPool2OrgPl_liv" description="Mass transfer from Portal Vein: Plasma to Liver: Plasma" mode="Logical" containerType="Other" dimension="Dimensionless" formula="NsuZN-J8e0GfGDyMq9eKfA" sourceAmount="3epVIeHC_0m65IYsJjSaDQ" targetAmount="3EA1OLywM0SY7jEyMKI0Hw" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="XeKLzMF970GS5nLI5miZSw" name="Skin_pls_Skin_bc" description="Neighborhood between Skin/Plasma and Skin/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="y3op8mU0PEKqOFIjtlmvxA" secondNeighbor="CkLwUzDt9Eqp-pbnsLmpig">
-              <Tags>
-                <Tag value="Skin_pls_Skin_bc" />
-                <Tag value="Neighborhood: Plasma / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="hnGw4HUjp0CRAcDZekFvTA" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Transport id="8fpXxvtRvUCrcR7lTIhMLw" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Other" dimension="Dimensionless" formula="KKECfOGvbkOpT6c2bOsGNA" sourceAmount="smW_5fUV7Uil14J2vlu7cA" targetAmount="uPQUKjkvEkeQDYVMvdnypA" />
-                  </Children>
-                </Container>
-                <Parameter id="x6qJ4eksQ0KEMw78q3pHtQ" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" formula="GALrLSN550SOkSBZHfYOWw" dim="Surface" quantityType="0" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="hXr6QTO91EOEque12h-3SA" name="Skin_int_Skin_cell" description="Neighborhood between Skin/Interstitial and Skin/Intracellular" mode="Logical" containerType="Other" firstNeighbor="ijwnJLM3Sk6gFSbU62epSA" secondNeighbor="2ZSmY1Z10EKqVM4VSYTauQ">
-              <Tags>
-                <Tag value="Skin_int_Skin_cell" />
-                <Tag value="Neighborhood: Interstitial / Intracellular" />
-              </Tags>
-              <Children>
-                <Container id="iX0VfrxXCUSItBDJelQlsA" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="xok3iaxhFEGfOGIs8rlSGg" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" formula="3cJBFwQjyUqzb_kQadzpHA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="IaH9Ytqi-UqgCbFAPbFUdQ" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="xQZ40Mn0s0Wf7QlpiyG1_w" dim="Velocity" quantityType="0" />
-                    <Parameter id="VTOiCnlsjkKVkSOloashzQ" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="3-LEyoK2GEOuCEV2otw_AQ" dim="Velocity" quantityType="0" />
-                    <Parameter id="n_kJlvA5wE2NiXnG46QefQ" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="DIQILkkEz06QbATD24Bttw" dim="Flow (volume)" quantityType="0" />
-                    <Parameter id="rvV1n5EmQk66kollQmIodA" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="GRkU-raPfUeXS_32oxTzjQ" dim="Flow (volume)" quantityType="0" />
-                    <Parameter id="L0FeM0VWtUiaJQqS8bmn9g" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="rDItnD8jEk2IlrE4iyeJCA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="6Kpd9yjyBEmG5vq7S4BiMw" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="VEUZP9ldME-coiRwZoeb1Q" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="iUAJuOsKmESQLZZwcAYKmA" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" formula="rUnJT0aDI02r4hOSUOhZog" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="UXmjZvf6a0-6bhhZvkf9zA" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" formula="aLkQ0X5eTE2M8z5GkHVDaw" dim="Dimensionless" quantityType="0" />
-                    <Transport id="_V_JWYZQiUSGHLceTICnmQ" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Other" dimension="Dimensionless" formula="jDuZTdW9uUGLW4bEhNEtVA" sourceAmount="YCuAfRjSFECzqzSBBgUTCQ" targetAmount="1O_wMQkPE0Kja-I5ZURsEw" />
-                  </Children>
-                </Container>
-                <Parameter id="LvYaGhlK70O5hE7r7RvybQ" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" formula="4V9XnCkWlUKUVlqMyUJUNg" dim="Surface" quantityType="0" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="ugZmf454_EyQPVNcfkQr-w" name="Skin_bc_VenousBlood_bc" description="Neighborhood between Skin/Blood Cells and Venous Blood/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="CkLwUzDt9Eqp-pbnsLmpig" secondNeighbor="vv8rxyxvYkasBnpcCaOSyg">
-              <Tags>
-                <Tag value="Skin_bc_VenousBlood_bc" />
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="YrGRLLIQzkq05FnpDukdwQ" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Transport id="g4459nkimUWhafOSGEZ5Eg" name="MassTransferOrgRBC2BloodPool" description="Mass transfer from organ: Blood Cells to Arterial Blood: Blood Cells" mode="Logical" containerType="Other" dimension="Dimensionless" formula="1gEjGCDk-0Sf8COP0aexWg" sourceAmount="uPQUKjkvEkeQDYVMvdnypA" targetAmount="FMF6RMb5pkyvcn1PXHNkgw" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="kzFYldbAJkiQvega7qSMMg" name="Skin_pls_Skin_int" description="Neighborhood between Skin/Plasma and Skin/Interstitial" mode="Logical" containerType="Other" firstNeighbor="y3op8mU0PEKqOFIjtlmvxA" secondNeighbor="ijwnJLM3Sk6gFSbU62epSA">
-              <Tags>
-                <Tag value="Skin_pls_Skin_int" />
-                <Tag value="Neighborhood: Plasma / Interstitial" />
-              </Tags>
-              <Children>
-                <Container id="Kit8WLkJtEOwUQ3smy8AOw" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="omJVCYkcRUyW2EQzYoQCFg" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" formula="w_nAvz8iNE-nacRlmHHCbw" dim="Velocity" quantityType="0" />
-                    <Parameter id="TrjOUHui60aGSgL0Jpxi5A" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" formula="-DEFSC4vn0ajeww6-OP5eg" dim="Dimensionless" quantityType="0" />
-                    <Transport id="gVoklXoal0im0HqKldmw9w" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Other" dimension="Dimensionless" formula="-saI86mrOUCDqMqPK8wNZA" sourceAmount="smW_5fUV7Uil14J2vlu7cA" targetAmount="YCuAfRjSFECzqzSBBgUTCQ" />
-                  </Children>
-                </Container>
-                <Parameter id="OPp8Ny8ivUmqrfeoGzgZRA" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" formula="QqpuR69_EU6Tp2rgm2Jl2A" dim="Surface" quantityType="0" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="-o6rN6Rm60-ee5lygKlVyQ" name="Skin_pls_VenousBlood_pls" description="Neighborhood between Skin/Plasma and Venous Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="y3op8mU0PEKqOFIjtlmvxA" secondNeighbor="R5jgBt3okEeUHClw7hT2EA">
-              <Tags>
-                <Tag value="Skin_pls_VenousBlood_pls" />
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="SGViUDaqn0qZYlUudaDWWw" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Transport id="25_zy__DNEGuQIQqfoH9fA" name="MassTransferOrgPl2BloodPool" description="Mass transfer from organ: Plasma to Venous Blood: Plasma" mode="Logical" containerType="Other" dimension="Dimensionless" formula="YqdggFYLWUqX4FrxaFR_Zg" sourceAmount="smW_5fUV7Uil14J2vlu7cA" targetAmount="0z8uD-0gmE61mkI_fDKAZQ" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="bMZ6AjV3IU2rfsHBLdn8jw" name="Spleen_bc_PortalVein_bc" description="Neighborhood between Spleen/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="iESkeOAbG0CcBzy_tL1kAg" secondNeighbor="UsK_koflU0aP-ubDRlslJQ">
-              <Tags>
-                <Tag value="Spleen_bc_PortalVein_bc" />
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="c2Zz-SXwc0yqdf-uBFco7w" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Transport id="T0UPJGTspUCPco8wysSKVQ" name="MassTransferOrgRBC2BloodPool_Pve" description="Mass transfer from organ: Blood Cells to Portal Vein: Blood Cells" mode="Logical" containerType="Other" dimension="Dimensionless" formula="iwi_FFQQ10Sx3L71FeS5Kg" sourceAmount="_bcxy0zn60iGPbh97kA1zA" targetAmount="F8UZepNEFEqiqDVPY4DDnA" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="sI96n9_-4k2smnn6gCmgfg" name="Spleen_int_Spleen_cell" description="Neighborhood between Spleen/Interstitial and Spleen/Intracellular" mode="Logical" containerType="Other" firstNeighbor="oB9TovQqSEa_v7Oay6iYqg" secondNeighbor="aM7rrOr_n0GUXbfM3fV19Q">
-              <Tags>
-                <Tag value="Spleen_int_Spleen_cell" />
-                <Tag value="Neighborhood: Interstitial / Intracellular" />
-              </Tags>
-              <Children>
-                <Container id="mvZlJUH4mU28mzijfBXWMg" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="hEsTfRttxEW89UDyUgtZmA" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="3-LEyoK2GEOuCEV2otw_AQ" dim="Velocity" quantityType="0" />
-                    <Parameter id="pWZ8duyeME2o8Hyqc6lfeQ" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="xQZ40Mn0s0Wf7QlpiyG1_w" dim="Velocity" quantityType="0" />
-                    <Parameter id="Nsbm-CEkBUiB0UKukLtqgw" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="DIQILkkEz06QbATD24Bttw" dim="Flow (volume)" quantityType="0" />
-                    <Parameter id="Z8Mzya2D8kqHXYeZlFTNig" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="GRkU-raPfUeXS_32oxTzjQ" dim="Flow (volume)" quantityType="0" />
-                    <Parameter id="z0N6xJy5OUChmtOgtkC1Lw" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="5EeM7xmL50-DmnNjf7Yrxg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="cHE2QK8Yw0Cb0YiRJ8BZtg" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="i3RaHz0JZEaUFSyQ1jsYwg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="4gP57Xz-EkKnbmcsZE50OQ" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" formula="bU1TZf1GKUyJ8fo2dqGPag" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="BMeYDZOKU0CVaS-FSC7muw" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" formula="3cJBFwQjyUqzb_kQadzpHA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="Bf4_zacHt0O9X_JLml6Vfw" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" formula="4prf7w9Rxki6p9_CWfBeyw" dim="Dimensionless" quantityType="0" />
-                    <Transport id="U_o1cITAnEOUDXI_SsfouQ" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Other" dimension="Dimensionless" formula="0NXt6IuBkkGC7MpQIdfk_Q" sourceAmount="45fG3wuu3UOBVvH2O21INw" targetAmount="jchB9qdsp0-c-FkIchy8iA" />
-                  </Children>
-                </Container>
-                <Parameter id="qVZu99LjaEiRE0LnuqHJ7w" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" formula="kXCzc4n0AEmUZmTpcC4VlQ" dim="Surface" quantityType="0" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="vsz9tF5CXEWUmQajZ5Qb-g" name="Spleen_pls_Spleen_bc" description="Neighborhood between Spleen/Plasma and Spleen/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="LZ_CQqYrBEO2uhzLfZltGA" secondNeighbor="iESkeOAbG0CcBzy_tL1kAg">
-              <Tags>
-                <Tag value="Spleen_pls_Spleen_bc" />
-                <Tag value="Neighborhood: Plasma / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="IcuDwRoxZ0SbvkKHoPSm6A" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Transport id="-E8UY2t3I0WExZ80OwdesA" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Other" dimension="Dimensionless" formula="kSFoh5-dbEO5E_VDly5IGQ" sourceAmount="PJw6pc0knU6Z5oByDI70zA" targetAmount="_bcxy0zn60iGPbh97kA1zA" />
-                  </Children>
-                </Container>
-                <Parameter id="lzRvUiB5mUSSRo4Miv4sew" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" formula="S6K8EY-zPUyHAPjGfdsKfA" dim="Surface" quantityType="0" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="rTuYYg9-A0uW-0ABVuhMaA" name="Spleen_pls_Spleen_int" description="Neighborhood between Spleen/Plasma and Spleen/Interstitial" mode="Logical" containerType="Other" firstNeighbor="LZ_CQqYrBEO2uhzLfZltGA" secondNeighbor="oB9TovQqSEa_v7Oay6iYqg">
-              <Tags>
-                <Tag value="Spleen_pls_Spleen_int" />
-                <Tag value="Neighborhood: Plasma / Interstitial" />
-              </Tags>
-              <Children>
-                <Container id="5w6zauwU_U6uN2YBxTIxzw" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="9g0vZ0zjHUyEUaWnDrBzqA" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" formula="-DEFSC4vn0ajeww6-OP5eg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="EAOl_RMcREmkH3ZRIy9GUw" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" formula="1-oAEt54FEemXKGh8gWTrw" dim="Velocity" quantityType="0" />
-                    <Transport id="RqJdNqTxqEGuonfoM6mINQ" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Other" dimension="Dimensionless" formula="JCS7s2NufEmo4pcS7LzrYw" sourceAmount="PJw6pc0knU6Z5oByDI70zA" targetAmount="45fG3wuu3UOBVvH2O21INw" />
-                  </Children>
-                </Container>
-                <Parameter id="CvwDVd5ZwkuoscCGvVPa5g" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" formula="Rx2uM1KsfUefpHxCw3crFw" dim="Surface" quantityType="0" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="Xf2YfHkLiE-d3v2q6nzyHw" name="Spleen_pls_PortalVein_pls" description="Neighborhood between Spleen/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="LZ_CQqYrBEO2uhzLfZltGA" secondNeighbor="t3RJcRrWZk6Yk-_IRw-vvA">
-              <Tags>
-                <Tag value="Spleen_pls_PortalVein_pls" />
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="HEf-tcGvtE6SgeOTFR86gQ" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Transport id="5EAB0FQUwkOpROoPtYkSBQ" name="MassTransferOrgPl2BloodPool_pve" description="Mass transfer from organ: Plasma to Portal Vein: Plasma" mode="Logical" containerType="Other" dimension="Dimensionless" formula="5_cas7sgt0Wl3pidEbfTbQ" sourceAmount="PJw6pc0knU6Z5oByDI70zA" targetAmount="3epVIeHC_0m65IYsJjSaDQ" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="BbQqd_UuZEyJDqZPQtxj3g" name="Saliva_slv_Saliva_slv" description="Neighborhood between Saliva/SalivaGland and Saliva/Saliva" mode="Logical" containerType="Other" firstNeighbor="Iicge5aH6EiCEWYDL9VURQ" secondNeighbor="2auTzdnvFkSIAWYzA2rhmg">
-              <Tags>
-                <Tag value="Saliva_slv_Saliva_slv" />
-                <Tag value="Neighborhood: SalivaGland / Saliva" />
-              </Tags>
-              <Children>
-                <Container id="I2kEk5DODkS0G42EI_9mNw" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="_2JSYs5aB0eMogjP1D68rw" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" formula="cEMgrNsWpkC3nbVT0QcsSw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="qBIQKz4X-0etSHm0Voij4g" name="SalivaPlasmaRatio" description="Ratio of saliva vs. plasma concentrations" persistable="0" isFixedValue="0" formula="ZYj8ctJTiUyRVN6ylL91Iw" dim="Dimensionless" quantityType="0" />
-                    <Transport id="Gzie5dickUGr8I8Tjg1ibg" name="PassiveDiffusionPlsToSaliva" description="Passive diffusion plasma to saliva" mode="Logical" containerType="Other" dimension="Dimensionless" formula="JvvD-ugGWUON2Jx_7tEGyw" sourceAmount="ypoi8e7mvkKINSwSQuLX6Q" targetAmount="YTmTWr5Cp0SC8YIKRKvwGw" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="Df1KwojCSUmz4046aV3Gtg" name="Duodenum_pls_Duodenum_int" description="Neighborhood between Small Intestine/Mucosa/Duodenum/Plasma and Small Intestine/Mucosa/Duodenum/Interstitial" mode="Logical" containerType="Other" firstNeighbor="qpsNmcf0yECPn6bPfvoWbA" secondNeighbor="ywuD3Bwyok28OM2s_VCT0w">
-              <Tags>
-                <Tag value="Duodenum_pls_Duodenum_int" />
-                <Tag value="Neighborhood: Plasma / Interstitial" />
-                <Tag value="Small intestine  neighborhood" />
-              </Tags>
-              <Children>
-                <Container id="2TXnWpMrTUeIw35_HGcQHQ" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="2Meh7ru7W0i-yNvNlve4IQ" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" formula="-DEFSC4vn0ajeww6-OP5eg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="tX2H6Eh1xUKyjRh8rnlI_Q" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" formula="ppxTnQXZ4Um1wA-P7-Mh_A" dim="Velocity" quantityType="0" />
-                    <Transport id="gODNPZoOpUed6aCMbaBv-A" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Other" dimension="Dimensionless" formula="61uKgoxWAEiBMo9LPT9hlA" sourceAmount="NuXtwyVbBESYGyhe3qyqWQ" targetAmount="I9BWMF8_3kSBQIDxrfcggQ" />
-                  </Children>
-                </Container>
-                <Parameter id="vUBQxWg2sUWZO0Dn3oyo3Q" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" formula="sbnQXlTL2kKcwHN7b1vDLQ" dim="Surface" quantityType="0" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="Y03EYuX0fkKk2NxQZ8HtlA" name="Duodenum_pls_Duodenum_bc" description="Neighborhood between Small Intestine/Mucosa/Duodenum/Plasma and Small Intestine/Mucosa/Duodenum/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="qpsNmcf0yECPn6bPfvoWbA" secondNeighbor="G67GNfr5nUejQBYiVNI7Gw">
-              <Tags>
-                <Tag value="Duodenum_pls_Duodenum_bc" />
-                <Tag value="Neighborhood: Plasma / BloodCells" />
-                <Tag value="Small intestine  neighborhood" />
-              </Tags>
-              <Children>
-                <Container id="nt-5RzX7dEKGqkUzWK8VQQ" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Transport id="D3uWzsRvYkmO16cGJGAlPw" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Other" dimension="Dimensionless" formula="oj1Amm1fq0mb0a3ETWM0QA" sourceAmount="NuXtwyVbBESYGyhe3qyqWQ" targetAmount="I-wcOfVzhUubhukFSm8Z-A" />
-                  </Children>
-                </Container>
-                <Parameter id="fe6s2lzkDUevjHuNZAtjAg" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" formula="jKwYj_gjR0OUSysUXD7jTA" dim="Surface" quantityType="0" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="g9Xw4jH8jEG7tw4CUod_Fg" name="Duodenum_int_Duodenum_cell" description="Neighborhood between Small Intestine/Mucosa/Duodenum/Interstitial and Small Intestine/Mucosa/Duodenum/Intracellular" mode="Logical" containerType="Other" firstNeighbor="ywuD3Bwyok28OM2s_VCT0w" secondNeighbor="yo07wiCfk0SB0-zR6Q-smQ">
-              <Tags>
-                <Tag value="Duodenum_int_Duodenum_cell" />
-                <Tag value="Neighborhood: Interstitial / Intracellular" />
-                <Tag value="Small intestine  neighborhood" />
-              </Tags>
-              <Children>
-                <Container id="Gz4IZCiIq0KVoo8BtdFL7w" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="doIvVKWWHUety35BKaNDnQ" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="xQZ40Mn0s0Wf7QlpiyG1_w" dim="Velocity" quantityType="0" />
-                    <Parameter id="IjFAlLKDAUmjdwTGLDOUQA" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="GRkU-raPfUeXS_32oxTzjQ" dim="Flow (volume)" quantityType="0" />
-                    <Parameter id="fHhgTNPKwk2l5rx3wf7qmQ" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="DIQILkkEz06QbATD24Bttw" dim="Flow (volume)" quantityType="0" />
-                    <Parameter id="69AH2zHIK065fu_3iH4o8A" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="wfMemtwXGESiod1l1v3HWg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="h2bhS1iasEeGnR6p0GnHyQ" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="Ml47YNbV20ecVdusL5c1qg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="9Q3baM8FOUGVe_7LBxrHeQ" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" formula="e9uSQfZ4e0-9cSWotkpUcw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="RSI4cCteYEKDWog1b_ld1A" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" formula="3cJBFwQjyUqzb_kQadzpHA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="AV425Km2XUaU111WVv6cNA" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="3-LEyoK2GEOuCEV2otw_AQ" dim="Velocity" quantityType="0" />
-                    <Parameter id="om44WGK8F0Sa703B5tMo4w" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" formula="c5popDFczEqzrHUDzoOb2w" dim="Dimensionless" quantityType="0" />
-                    <Transport id="_Zfq_I6wpk6AsJ6TzNeZyA" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Other" dimension="Dimensionless" formula="8lFfJ5CVyk-7nhlZx7KjoA" sourceAmount="I9BWMF8_3kSBQIDxrfcggQ" targetAmount="lzS0IgRFyUe26aoyeKkgTw" />
-                  </Children>
-                </Container>
-                <Parameter id="XSBY9HSAaEuhPniD-f8G_Q" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" formula="ewdGSxeCwkGu9jURN5mSjw" dim="Surface" quantityType="0" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="XHrFH5y3pE2jTrlERj94OA" name="UpperJejunum_pls_UpperJejunum_bc" description="Neighborhood between Small Intestine/Mucosa/Upper Jejunum/Plasma and Small Intestine/Mucosa/Upper Jejunum/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="qeqwoTSkakOVMFqQIp36Rw" secondNeighbor="bkf1EKQC6UWHf1_K1uz-Hg">
-              <Tags>
-                <Tag value="UpperJejunum_pls_UpperJejunum_bc" />
-                <Tag value="Neighborhood: Plasma / BloodCells" />
-                <Tag value="Small intestine  neighborhood" />
-              </Tags>
-              <Children>
-                <Container id="bM61hQcRykSHeNvCZcz-Mg" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Transport id="MuJmFAWfnkmUmmy4WpyFwQ" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Other" dimension="Dimensionless" formula="QFYxDLFExUi3_xChhwf4Xg" sourceAmount="Cyoj-iIBBUK7nqW_avA9uw" targetAmount="9xjcN-quk0yrAPxO3xJMjA" />
-                  </Children>
-                </Container>
-                <Parameter id="pKAlh3g8wESATv7kA20afg" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" formula="QSfN2OtpPUa5wYMTRhtLgA" dim="Surface" quantityType="0" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="Zm8Rsq1EAEiVE1QNPfSpOA" name="UpperJejunum_int_UpperJejunum_cell" description="Neighborhood between Small Intestine/Mucosa/Upper Jejunum/Interstitial and Small Intestine/Mucosa/Upper Jejunum/Intracellular" mode="Logical" containerType="Other" firstNeighbor="THYGK8yE7UOOTBWK-3FzrA" secondNeighbor="N3VDr-XRDkSr4mlVC2UkHQ">
-              <Tags>
-                <Tag value="UpperJejunum_int_UpperJejunum_cell" />
-                <Tag value="Neighborhood: Interstitial / Intracellular" />
-                <Tag value="Small intestine  neighborhood" />
-              </Tags>
-              <Children>
-                <Container id="VvzwOlqXME-f7jS5SidN8Q" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="Mw4enosdrkSQx2VpnOYPaQ" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" formula="_OnU9PTlkE6e7T2J9hpcZw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="MuJA2CZikU2cnOPcey7Asw" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" formula="3cJBFwQjyUqzb_kQadzpHA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="bUOBNrdyUUqR6omjvhBZSg" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="xQZ40Mn0s0Wf7QlpiyG1_w" dim="Velocity" quantityType="0" />
-                    <Parameter id="4PO8HUGk9EuBW2zJxDB3Jg" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="3-LEyoK2GEOuCEV2otw_AQ" dim="Velocity" quantityType="0" />
-                    <Parameter id="glWD9fXCKUePmLB0JVxjUA" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="DIQILkkEz06QbATD24Bttw" dim="Flow (volume)" quantityType="0" />
-                    <Parameter id="neRJm07IQUelpxH1VxuRhQ" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="GRkU-raPfUeXS_32oxTzjQ" dim="Flow (volume)" quantityType="0" />
-                    <Parameter id="m2zcMdGMWE-NAZK07yWSTQ" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="Ua59kVFbS0yCJL5FxeMY_w" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="LuUl1QajrE6pRAM8DVdjDg" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="8JOULUAudES3DREvGHC_sQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="U2eF_xpcYUir00E4saI40Q" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" formula="c5popDFczEqzrHUDzoOb2w" dim="Dimensionless" quantityType="0" />
-                    <Transport id="mKyv-RzfEUa3US3HUj6AhQ" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Other" dimension="Dimensionless" formula="qRrw7WQEcU230xvC3x456w" sourceAmount="zTsutIMy7kiNK_k750RykQ" targetAmount="PHa0MNb1DUaXgdsbKCSSmQ" />
-                  </Children>
-                </Container>
-                <Parameter id="Q1bUwlEo9ECOAJnWzRqIiw" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" formula="LwQPVKtuPEOTho7XwNaVPQ" dim="Surface" quantityType="0" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="TyxMXT73oU-ePWprZdJOog" name="UpperJejunum_pls_UpperJejunum_int" description="Neighborhood between Small Intestine/Mucosa/Upper Jejunum/Plasma and Small Intestine/Mucosa/Upper Jejunum/Interstitial" mode="Logical" containerType="Other" firstNeighbor="qeqwoTSkakOVMFqQIp36Rw" secondNeighbor="THYGK8yE7UOOTBWK-3FzrA">
-              <Tags>
-                <Tag value="UpperJejunum_pls_UpperJejunum_int" />
-                <Tag value="Neighborhood: Plasma / Interstitial" />
-                <Tag value="Small intestine  neighborhood" />
-              </Tags>
-              <Children>
-                <Container id="9LiohJj-eEem2RiLIa1hnw" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="u--iUQIYMk2W0KUDg0Z45Q" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" formula="HFsXIzjAAU--1EQHp4b6rg" dim="Velocity" quantityType="0" />
-                    <Parameter id="1n2-TC3CAESiTQV2X_bJPg" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" formula="-DEFSC4vn0ajeww6-OP5eg" dim="Dimensionless" quantityType="0" />
-                    <Transport id="b9I5OeJGNkurXNsfKJaL8Q" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Other" dimension="Dimensionless" formula="4JMLfWt9dESd6dFZwdXuOQ" sourceAmount="Cyoj-iIBBUK7nqW_avA9uw" targetAmount="zTsutIMy7kiNK_k750RykQ" />
-                  </Children>
-                </Container>
-                <Parameter id="8Mkl8myyJ0uZof_Yzqc5Ug" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" formula="EDQyGd1LLEen1zzEKFGMUw" dim="Surface" quantityType="0" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="ijhZoEn8t0SMwj1hJYCXjA" name="LowerJejunum_pls_LowerJejunum_int" description="Neighborhood between Small Intestine/Mucosa/Lower Jejunum/Plasma and Small Intestine/Mucosa/Lower Jejunum/Interstitial" mode="Logical" containerType="Other" firstNeighbor="4Q7zgvuqcE-QpUYXuYeQwA" secondNeighbor="5PomAWE2VkC-slCzt2mnVw">
-              <Tags>
-                <Tag value="LowerJejunum_pls_LowerJejunum_int" />
-                <Tag value="Neighborhood: Plasma / Interstitial" />
-                <Tag value="Small intestine  neighborhood" />
-              </Tags>
-              <Children>
-                <Container id="2wjfLyYJm0eKv16jRhIjXQ" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="_Zi3Z5Far0SgMkyjzswNsw" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" formula="nRAnse0Okk--Aq3Tsj2eQA" dim="Velocity" quantityType="0" />
-                    <Parameter id="Ju3zg2hfwkWIJSkam4OllA" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" formula="-DEFSC4vn0ajeww6-OP5eg" dim="Dimensionless" quantityType="0" />
-                    <Transport id="DD6IDsyBQkm3L8TFCCKDZg" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Other" dimension="Dimensionless" formula="G9VxsLi0qUiLcaONkc40wg" sourceAmount="IBK3hooVzE2t9QgNnGZ_0w" targetAmount="5z92tYfgbEi8q7N6MN6VRQ" />
-                  </Children>
-                </Container>
-                <Parameter id="q9Y5soSqjEuSy1HfIAJ8DA" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" formula="im9aPGgOV0Ock6EyDbls9Q" dim="Surface" quantityType="0" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="jb4Px6WybEKrSwugjMUhMA" name="LowerJejunum_pls_LowerJejunum_bc" description="Neighborhood between Small Intestine/Mucosa/Lower Jejunum/Plasma and Small Intestine/Mucosa/Lower Jejunum/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="4Q7zgvuqcE-QpUYXuYeQwA" secondNeighbor="MN94QcuVH0aTgduRFgCruw">
-              <Tags>
-                <Tag value="LowerJejunum_pls_LowerJejunum_bc" />
-                <Tag value="Neighborhood: Plasma / BloodCells" />
-                <Tag value="Small intestine  neighborhood" />
-              </Tags>
-              <Children>
-                <Container id="GyNaGOjJlkixE6yJvYEl_A" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Transport id="nluDWMfCn0CjtNYCDEnXCQ" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Other" dimension="Dimensionless" formula="tTM1bGV52UuuZY69twHuXA" sourceAmount="IBK3hooVzE2t9QgNnGZ_0w" targetAmount="pkwIe2c8m0C2ShdFKX-RLw" />
-                  </Children>
-                </Container>
-                <Parameter id="BuPfEqJcrkiCHlZ3jZk6ig" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" formula="KtMAYSW_Lk2bBgscSGA6Fw" dim="Surface" quantityType="0" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="8WtsQ47hkkKt078TNsN0AQ" name="LowerJejunum_int_LowerJejunum_cell" description="Neighborhood between Small Intestine/Mucosa/Lower Jejunum/Interstitial and Small Intestine/Mucosa/Lower Jejunum/Intracellular" mode="Logical" containerType="Other" firstNeighbor="5PomAWE2VkC-slCzt2mnVw" secondNeighbor="5vmKOnRiF06lebQSRhQJOg">
-              <Tags>
-                <Tag value="LowerJejunum_int_LowerJejunum_cell" />
-                <Tag value="Neighborhood: Interstitial / Intracellular" />
-                <Tag value="Small intestine  neighborhood" />
-              </Tags>
-              <Children>
-                <Container id="Z4OxfZPQKEKX6m_MQaBpaA" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="WsPPyWx-b0yjUQA5Bcu5TA" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="DIQILkkEz06QbATD24Bttw" dim="Flow (volume)" quantityType="0" />
-                    <Parameter id="8bcwKibikkqHjAWUIgYGkw" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="GRkU-raPfUeXS_32oxTzjQ" dim="Flow (volume)" quantityType="0" />
-                    <Parameter id="l-WpNu6tDEWkBv2AYp3N1Q" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="oHNjufq4cE2UtwxChKV6Kw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="9daQexyfMEe0AHL3d4D5Fw" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="nEWCJ2c4w06qO_q87TnqaA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="Xq4-lz_e6kmV4M8v1bX-6w" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" formula="R_QLuLAdzkKL4Qtjsedqhw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="iQvlGfV8dEKJdoNUhYxPeA" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" formula="3cJBFwQjyUqzb_kQadzpHA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="6MgXo7QrtUStuOU7Uf5IAg" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="3-LEyoK2GEOuCEV2otw_AQ" dim="Velocity" quantityType="0" />
-                    <Parameter id="kFboYjY_YE2giIH9dpotLA" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="xQZ40Mn0s0Wf7QlpiyG1_w" dim="Velocity" quantityType="0" />
-                    <Parameter id="SEjbgVjn10qdX4XrUJ9Bfw" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" formula="c5popDFczEqzrHUDzoOb2w" dim="Dimensionless" quantityType="0" />
-                    <Transport id="xBGbAk37FEqiLDGJU_GfKA" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Other" dimension="Dimensionless" formula="il5ZHPh4e0yHmCUodm4ISA" sourceAmount="5z92tYfgbEi8q7N6MN6VRQ" targetAmount="WWPxNCTxFUiGAAGb_xVXCQ" />
-                  </Children>
-                </Container>
-                <Parameter id="FsOxyOC2AEq6gPwnP2NiAw" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" formula="GJRjp2riOEmMM-0zpFbJiA" dim="Surface" quantityType="0" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="I-gCaZtpKEGVBG0kUV2nIg" name="UpperIleum_pls_UpperIleum_int" description="Neighborhood between Small Intestine/Mucosa/Upper Ileum/Plasma and Small Intestine/Mucosa/Upper Ileum/Interstitial" mode="Logical" containerType="Other" firstNeighbor="eqxADnXJ7U-yx7RZ9RRnGQ" secondNeighbor="h_HrULaBNU63NUv9o6Picg">
-              <Tags>
-                <Tag value="UpperIleum_pls_UpperIleum_int" />
-                <Tag value="Neighborhood: Plasma / Interstitial" />
-                <Tag value="Small intestine  neighborhood" />
-              </Tags>
-              <Children>
-                <Container id="QcqrEm72IEqG-Kf84XCwHw" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="odEs0Ds_rkSvASDDuUuD9Q" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" formula="-DEFSC4vn0ajeww6-OP5eg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="YS2D1ed6AU2XgeCOcAb1Yw" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" formula="jOxNVu1J7UqrgSp-9BAi3g" dim="Velocity" quantityType="0" />
-                    <Transport id="uWLfugt6YkaFQVQmf4Tn-A" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Other" dimension="Dimensionless" formula="x_2jXmkK5EC69tYPXumEFQ" sourceAmount="3LnxhiZCq0-_1-jmaYhb8w" targetAmount="p0ZWuAT6gE-MyE4o81OmDA" />
-                  </Children>
-                </Container>
-                <Parameter id="3YHf_JsldkKhsSkP_XC3fQ" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" formula="qkPVuV92Wkut31d-uq0-mw" dim="Surface" quantityType="0" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="s3gp3frXHU-7CarOWEFjCg" name="UpperIleum_pls_UpperIleum_bc" description="Neighborhood between Small Intestine/Mucosa/Upper Ileum/Plasma and Small Intestine/Mucosa/Upper Ileum/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="eqxADnXJ7U-yx7RZ9RRnGQ" secondNeighbor="O523UhgKSkeprp67LMaDag">
-              <Tags>
-                <Tag value="UpperIleum_pls_UpperIleum_bc" />
-                <Tag value="Neighborhood: Plasma / BloodCells" />
-                <Tag value="Small intestine  neighborhood" />
-              </Tags>
-              <Children>
-                <Container id="R_8LT1Suw0-AZCynGwakOw" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Transport id="pgQH-3uVrUaBsg7SSLKCdg" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Other" dimension="Dimensionless" formula="thFlSpvVikCMdx9GBbXlKA" sourceAmount="3LnxhiZCq0-_1-jmaYhb8w" targetAmount="W8KLhlsWkU6-nxbVlLgfDA" />
-                  </Children>
-                </Container>
-                <Parameter id="Vm7n0FJY7kCZkWCn0AH4Ww" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" formula="ZljeZ1blgku1X5HTiX3htw" dim="Surface" quantityType="0" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="lL9WWpSvNEGEmtFiUo4KyQ" name="UpperIleum_int_UpperIleum_cell" description="Neighborhood between Small Intestine/Mucosa/Upper Ileum/Interstitial and Small Intestine/Mucosa/Upper Ileum/Intracellular" mode="Logical" containerType="Other" firstNeighbor="h_HrULaBNU63NUv9o6Picg" secondNeighbor="gBiM91b0lEOFJj41Hgmg7Q">
-              <Tags>
-                <Tag value="UpperIleum_int_UpperIleum_cell" />
-                <Tag value="Neighborhood: Interstitial / Intracellular" />
-                <Tag value="Small intestine  neighborhood" />
-              </Tags>
-              <Children>
-                <Container id="XMmzZdU4j0q1UjXcat19hA" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="ay3ODoabF0WSsdFPm3zjVA" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" formula="v6QrpJV7RkOjxuxVNh8gEg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="7iGqcCIM40Sr8zYoQWpQ6w" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="xQZ40Mn0s0Wf7QlpiyG1_w" dim="Velocity" quantityType="0" />
-                    <Parameter id="qYqQr6PAj0SrzxCon49elw" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="3-LEyoK2GEOuCEV2otw_AQ" dim="Velocity" quantityType="0" />
-                    <Parameter id="Tw_-rjvr8ESe9IgYAzKt_A" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="DIQILkkEz06QbATD24Bttw" dim="Flow (volume)" quantityType="0" />
-                    <Parameter id="qLTaVNkthkOGg-F1z8MNXQ" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="GRkU-raPfUeXS_32oxTzjQ" dim="Flow (volume)" quantityType="0" />
-                    <Parameter id="DiI3jCt4mU2ywY8C1TCwFQ" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="DPC3rdcUNEWyXJ4Ekgq49Q" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="PcVKXufCJ0eD3KqJo0x-nA" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="DGerB5MmyE6l4v-_fwuMfQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="CyGcFtIE3kmBNd_WWvVkrQ" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" formula="3cJBFwQjyUqzb_kQadzpHA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="Pc6AY29Fl0CySep5XspLNQ" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" formula="c5popDFczEqzrHUDzoOb2w" dim="Dimensionless" quantityType="0" />
-                    <Transport id="ccqnnhyikEWtehqlxAUGkA" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Other" dimension="Dimensionless" formula="878KXh43aUaBNhMJO6_-ow" sourceAmount="p0ZWuAT6gE-MyE4o81OmDA" targetAmount="mGYOXZMgJUGhksXmlLzipQ" />
-                  </Children>
-                </Container>
-                <Parameter id="_huSl2ncmEyLHZEeUO03bA" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" formula="5rm6fuRNzUifBRvkMi4Mxw" dim="Surface" quantityType="0" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="dNJNs8tlY06YEk06WT5aZA" name="LowerIleum_pls_LowerIleum_int" description="Neighborhood between Small Intestine/Mucosa/Lower Ileum/Plasma and Small Intestine/Mucosa/Lower Ileum/Interstitial" mode="Logical" containerType="Other" firstNeighbor="2U7EZ2uO6USg9Rq74oJ7og" secondNeighbor="40GEupwcu0KOCUrSxYbAIg">
-              <Tags>
-                <Tag value="LowerIleum_pls_LowerIleum_int" />
-                <Tag value="Neighborhood: Plasma / Interstitial" />
-                <Tag value="Small intestine  neighborhood" />
-              </Tags>
-              <Children>
-                <Container id="8q7nNHSD3kae7xcjyiCPBA" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="ztCNoFnmVEe-xB8E5DmdfQ" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" formula="-DEFSC4vn0ajeww6-OP5eg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="IEdk6b1SkkaRB1AfXxyzpQ" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" formula="-CbzPvUIYEKUBXpeEfOZpg" dim="Velocity" quantityType="0" />
-                    <Transport id="_CVpIws5mUmfJu3Fux74kA" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Other" dimension="Dimensionless" formula="AoUtrNGvMEeNtynnOoJnvA" sourceAmount="bh7HbBF4F0WuPbCIz5_eSQ" targetAmount="-D_MAFpGl0miz5YGijWeeQ" />
-                  </Children>
-                </Container>
-                <Parameter id="hMtUNv4wAUeYzT2b9njPUA" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" formula="c4xnLpRPz0OcVylYmKMOhw" dim="Surface" quantityType="0" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="BhiqDEHvPk-O78ZPDaEbcw" name="LowerIleum_pls_LowerIleum_bc" description="Neighborhood between Small Intestine/Mucosa/Lower Ileum/Plasma and Small Intestine/Mucosa/Lower Ileum/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="2U7EZ2uO6USg9Rq74oJ7og" secondNeighbor="y0laXWaK_0ejrydIy9XoSA">
-              <Tags>
-                <Tag value="LowerIleum_pls_LowerIleum_bc" />
-                <Tag value="Neighborhood: Plasma / BloodCells" />
-                <Tag value="Small intestine  neighborhood" />
-              </Tags>
-              <Children>
-                <Container id="los56PflSkeurr80AYyV5A" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Transport id="U3XWrCDzvUqqZpixHha-aQ" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Other" dimension="Dimensionless" formula="cnn_0Sh9O06ZP3ZpKcKCiw" sourceAmount="bh7HbBF4F0WuPbCIz5_eSQ" targetAmount="FMCNNfjTpk2M8Oq8kAgVDA" />
-                  </Children>
-                </Container>
-                <Parameter id="BDNI-6RKbUaeI_c5MFHyAA" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" formula="vYYXmzAL4k6_0Pu6a-aicg" dim="Surface" quantityType="0" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="Se6EjpxM20-f_O_CoTRqeQ" name="LowerIleum_int_LowerIleum_cell" description="Neighborhood between Small Intestine/Mucosa/Lower Ileum/Interstitial and Small Intestine/Mucosa/Lower Ileum/Intracellular" mode="Logical" containerType="Other" firstNeighbor="40GEupwcu0KOCUrSxYbAIg" secondNeighbor="pZKqZ19W4kqEFXqZkxgETw">
-              <Tags>
-                <Tag value="LowerIleum_int_LowerIleum_cell" />
-                <Tag value="Neighborhood: Interstitial / Intracellular" />
-                <Tag value="Small intestine  neighborhood" />
-              </Tags>
-              <Children>
-                <Container id="uqlLqYOvFE6mDkq9uACH7Q" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="JXS_IketAECLmD515F3FgQ" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="7n357ikMfEKsZHxfIklAkg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="NjTCJnFBm0ytcwCsG86E7A" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="xQZ40Mn0s0Wf7QlpiyG1_w" dim="Velocity" quantityType="0" />
-                    <Parameter id="8v8ateZyUki9qiFoAYk8wg" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="3-LEyoK2GEOuCEV2otw_AQ" dim="Velocity" quantityType="0" />
-                    <Parameter id="liCeSwhRxkCmn0yOsIadbg" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="GRkU-raPfUeXS_32oxTzjQ" dim="Flow (volume)" quantityType="0" />
-                    <Parameter id="g3I_DQfPWkiiEv7E1zspPg" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="LBJ4Kn45KEusam614Q3J7Q" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="Qqcw0ypFuUWUfN5aQXpBow" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" formula="k6-j2eh5ZkS0fnsO9tmPHQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="IfQp9zYrMU-v0C1UZ2iw4Q" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" formula="3cJBFwQjyUqzb_kQadzpHA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="Gxkjk9-lwUG4R62GVsfL-Q" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="DIQILkkEz06QbATD24Bttw" dim="Flow (volume)" quantityType="0" />
-                    <Parameter id="iEHdl8Hk_ECboTE_N_fv3Q" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" formula="c5popDFczEqzrHUDzoOb2w" dim="Dimensionless" quantityType="0" />
-                    <Transport id="BUa5G5u7F0eO3bcmc5AQUg" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Other" dimension="Dimensionless" formula="kq1LykX5u0WsWNkHyrMmxw" sourceAmount="-D_MAFpGl0miz5YGijWeeQ" targetAmount="RReUSXdPAki3FARiRF47pg" />
-                  </Children>
-                </Container>
-                <Parameter id="RH8Y11r5tUizNNuOcmuU3w" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" formula="xgeAnlXqs0uqA8cSrNjyug" dim="Surface" quantityType="0" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="fhsJR3npgkWsPhwqvzO2Gw" name="Caecum_pls_Caecum_int" description="Neighborhood between Large Intestine/Mucosa/Cecum/Plasma and Large Intestine/Mucosa/Cecum/Interstitial" mode="Logical" containerType="Other" firstNeighbor="l8icBJ2uN0KH4u_hLlRE-Q" secondNeighbor="XQ9QHp4bX0ieSHXh2FVHVw">
-              <Tags>
-                <Tag value="Caecum_pls_Caecum_int" />
-                <Tag value="Large intestine  neighborhood" />
-                <Tag value="Neighborhood: Plasma / Interstitial" />
-              </Tags>
-              <Children>
-                <Container id="tR21yq6E3UeJGjWfSxajrQ" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="gKrkhbO7_kKj6iyNp4UCrQ" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" formula="-DEFSC4vn0ajeww6-OP5eg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="VLlp1FnLTkurE50Ve_0hbQ" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" formula="GQg304dBu0G1ILPIKrVL4Q" dim="Velocity" quantityType="0" />
-                    <Transport id="nuOCBCjyLkqTZ4XDGXAGwA" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Other" dimension="Dimensionless" formula="hBus-7OOuEKHTahZ93T4xQ" sourceAmount="0BQVZSFbd0yvGdZJo-TkmQ" targetAmount="l5UJjzesd0aVZxrz4twDag" />
-                  </Children>
-                </Container>
-                <Parameter id="qcGyoEYHgUi34Hhzc6fW5Q" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" formula="efHx7hG1ZUG-8gtdACp0VQ" dim="Surface" quantityType="0" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="gbzxApBWF0OGxr4nG_VDoQ" name="Caecum_pls_Caecum_bc" description="Neighborhood between Large Intestine/Mucosa/Cecum/Plasma and Large Intestine/Mucosa/Cecum/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="l8icBJ2uN0KH4u_hLlRE-Q" secondNeighbor="z3nIn6C3j0yVWC-W8t3Ztg">
-              <Tags>
-                <Tag value="Caecum_pls_Caecum_bc" />
-                <Tag value="Large intestine  neighborhood" />
-                <Tag value="Neighborhood: Plasma / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="y4xISIKarUqpNOun4qhZBg" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Transport id="xmbroIX1xEqMZGiY-mcf-w" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Other" dimension="Dimensionless" formula="SrIFveaJN0GBYHTsYaeWmQ" sourceAmount="0BQVZSFbd0yvGdZJo-TkmQ" targetAmount="Bdz3BSeKVE6ApvHc1Oikmg" />
-                  </Children>
-                </Container>
-                <Parameter id="ZvaqRl6e0U60qDAZbXwbOw" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" formula="DZbEdputSkqCSdQyHLMLlw" dim="Surface" quantityType="0" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="YrgnJAMUQU2RfsvyNDWBcw" name="Caecum_int_Caecum_cell" description="Neighborhood between Large Intestine/Mucosa/Cecum/Interstitial and Large Intestine/Mucosa/Cecum/Intracellular" mode="Logical" containerType="Other" firstNeighbor="XQ9QHp4bX0ieSHXh2FVHVw" secondNeighbor="owoyJrHWdkm0XLbwyDZ8rQ">
-              <Tags>
-                <Tag value="Caecum_int_Caecum_cell" />
-                <Tag value="Large intestine  neighborhood" />
-                <Tag value="Neighborhood: Interstitial / Intracellular" />
-              </Tags>
-              <Children>
-                <Container id="wsUCPYIeg0q7uhc0ZiYiLQ" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="8gEmA9az6kmbXvSYS7Hj-Q" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="dfYpLJtT8EKgZvDCUKka9Q" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="7mAnbgoxXk-hHvCrfMJG5Q" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="xQZ40Mn0s0Wf7QlpiyG1_w" dim="Velocity" quantityType="0" />
-                    <Parameter id="uG_rRP6Tp0KkOvxvyopHWg" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="3-LEyoK2GEOuCEV2otw_AQ" dim="Velocity" quantityType="0" />
-                    <Parameter id="ImB28ZdzMkeVicqrzfVqjA" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="GRkU-raPfUeXS_32oxTzjQ" dim="Flow (volume)" quantityType="0" />
-                    <Parameter id="MgFfnsn7j0Wkg2GuLW5FsA" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="_DivP9f_d0WbX8eneoHLzw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="AV0Pkdohl0yBE8tsigFRiA" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" formula="B88XgU-V3EGzTEOpEk0f5w" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="gtMh0E_o90O-9-_6PhvZdg" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" formula="3cJBFwQjyUqzb_kQadzpHA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="GFfR6hquLUONvLxTAQzGgA" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="DIQILkkEz06QbATD24Bttw" dim="Flow (volume)" quantityType="0" />
-                    <Parameter id="O1jzJOkuOUSt_RtqoMQJvA" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" formula="2_XVrQuJi0a9xveJ8sbz5g" dim="Dimensionless" quantityType="0" />
-                    <Transport id="PA5VOmkZukaebgZcNJa8dg" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Other" dimension="Dimensionless" formula="KrxtfW_FPUS6WTDA8ARGng" sourceAmount="l5UJjzesd0aVZxrz4twDag" targetAmount="wCOP5C6iSUaesCPdCtMtCg" />
-                  </Children>
-                </Container>
-                <Parameter id="2qI8k34y0EmDlPvk-_CG-g" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" formula="Yhg5qgws_0OXT4-MSE1fiA" dim="Surface" quantityType="0" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="cPlwBURK306BGJ4W9P0GZQ" name="ColonAscendens_pls_ColonAscendens_int" description="Neighborhood between Large Intestine/Mucosa/Colon Ascendens/Plasma and Large Intestine/Mucosa/Colon Ascendens/Interstitial" mode="Logical" containerType="Other" firstNeighbor="BkigLfGvSkiooZ67DLK2NQ" secondNeighbor="3wSRCym4P0qw0qkBrNzwjA">
-              <Tags>
-                <Tag value="ColonAscendens_pls_ColonAscendens_int" />
-                <Tag value="Large intestine  neighborhood" />
-                <Tag value="Neighborhood: Plasma / Interstitial" />
-              </Tags>
-              <Children>
-                <Container id="wIJ35rw9EEWeG_qDN2994Q" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="aBY0Q4Jvi0yYD0z9JdOAag" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" formula="Ie7kypoJnUmkbBmsXT2Hsw" dim="Velocity" quantityType="0" />
-                    <Parameter id="0Qg1KI0xNkKjDE0pNmQrcw" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" formula="-DEFSC4vn0ajeww6-OP5eg" dim="Dimensionless" quantityType="0" />
-                    <Transport id="RIdTbb4qCEq9kiwRLdysMQ" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Other" dimension="Dimensionless" formula="QVt1rZLZAUGvy3CNaWJrMQ" sourceAmount="6ewOCi0jbU6RbncNeaX1hw" targetAmount="G2LxNyTHWEOKC4Gnxt18xA" />
-                  </Children>
-                </Container>
-                <Parameter id="IT_QaKiaIk--8b4Rh7JABA" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" formula="MiaRU0ijykOBAuiUoGmWfQ" dim="Surface" quantityType="0" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="7iuVGZnIdEmS62t---0-kg" name="ColonAscendens_int_ColonAscendens_cell" description="Neighborhood between Large Intestine/Mucosa/Colon Ascendens/Interstitial and Large Intestine/Mucosa/Colon Ascendens/Intracellular" mode="Logical" containerType="Other" firstNeighbor="3wSRCym4P0qw0qkBrNzwjA" secondNeighbor="iBBpeGvAM0mWO2YbgWcZFw">
-              <Tags>
-                <Tag value="ColonAscendens_int_ColonAscendens_cell" />
-                <Tag value="Large intestine  neighborhood" />
-                <Tag value="Neighborhood: Interstitial / Intracellular" />
-              </Tags>
-              <Children>
-                <Container id="0BzFwx4e50eBN6OQ03GR9w" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="BLESJQYPcUa6LfMYXvf-MQ" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="GRkU-raPfUeXS_32oxTzjQ" dim="Flow (volume)" quantityType="0" />
-                    <Parameter id="lHClDhCm2kKRnY8OU1n3YQ" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="xQZ40Mn0s0Wf7QlpiyG1_w" dim="Velocity" quantityType="0" />
-                    <Parameter id="AL1MUtKx80GIATXwtK5eRQ" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="DIQILkkEz06QbATD24Bttw" dim="Flow (volume)" quantityType="0" />
-                    <Parameter id="7Wl8azUCJ0uvc7sVjonIaw" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="FCB3BYm4A0CH2ofaB9bZSQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="XkxPLCoFs0-MePM6F17m_A" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="7ZtMS43A-0exMBj4yv12uQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="TC2Rk4lJr0ekK4F8u5qMow" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" formula="Jo8RbKCIXECxrtrmPsJbYg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="30JHepUbukKOO-NgJjuwtA" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" formula="3cJBFwQjyUqzb_kQadzpHA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="rlo-UMgYEkad2HgBcJLRiQ" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="3-LEyoK2GEOuCEV2otw_AQ" dim="Velocity" quantityType="0" />
-                    <Parameter id="pRmZFEjs2ECtpjXYG_hglA" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" formula="2_XVrQuJi0a9xveJ8sbz5g" dim="Dimensionless" quantityType="0" />
-                    <Transport id="uOrVBFkS10elB8C8Pux4NQ" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Other" dimension="Dimensionless" formula="RIfX3I8N00KuSxjdET_YQA" sourceAmount="G2LxNyTHWEOKC4Gnxt18xA" targetAmount="xnxvY69E7EKFACGGZTKgzg" />
-                  </Children>
-                </Container>
-                <Parameter id="kQU1GraRBU6dW1JJSTArrA" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" formula="sHYV5_XjD0C0S5CMzk2mCg" dim="Surface" quantityType="0" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="2oLBMhQC40i77lZo19tj9g" name="ColonAscendens_pls_ColonAscendens_bc" description="Neighborhood between Large Intestine/Mucosa/Colon Ascendens/Plasma and Large Intestine/Mucosa/Colon Ascendens/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="BkigLfGvSkiooZ67DLK2NQ" secondNeighbor="aBWYhB1S5EmhC-3vnT5kZg">
-              <Tags>
-                <Tag value="ColonAscendens_pls_ColonAscendens_bc" />
-                <Tag value="Large intestine  neighborhood" />
-                <Tag value="Neighborhood: Plasma / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="a-55WujIS0KHy-NlclEV9w" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Transport id="CcFtvpPNbEef5Ywb50myuQ" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Other" dimension="Dimensionless" formula="Wzr_6-v7U06x3fogfclN0Q" sourceAmount="6ewOCi0jbU6RbncNeaX1hw" targetAmount="2LtEnxRQ-E68v82BoICp1A" />
-                  </Children>
-                </Container>
-                <Parameter id="8ymCDhtP10qCmikMvxPCSQ" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" formula="ND1K07x4E0GHI-GudgiLGQ" dim="Surface" quantityType="0" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="EU9yNXeV1Ee-nAMI6ucdYw" name="ColonTransversum_pls_ColonTransversum_bc" description="Neighborhood between Large Intestine/Mucosa/Colon Transversum/Plasma and Large Intestine/Mucosa/Colon Transversum/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="j1XM0vRHAEaTiu2blg0NgQ" secondNeighbor="4h08SDSRP0uZygWcIRA7mg">
-              <Tags>
-                <Tag value="ColonTransversum_pls_ColonTransversum_bc" />
-                <Tag value="Large intestine  neighborhood" />
-                <Tag value="Neighborhood: Plasma / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="bTwsWWvQ70ugb63mJ74cHw" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Transport id="nVtS5daO20CCu8UVaZ6Pog" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Other" dimension="Dimensionless" formula="O5LT1xAouUO5XvFbjrYgHg" sourceAmount="SLgG3jH9c0WpTyMIPQBI2g" targetAmount="DQ3BvfhWu0maydUENsDylg" />
-                  </Children>
-                </Container>
-                <Parameter id="oHj39tRzvEqgGn0aOmk0bg" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" formula="K6GMjq1wA0-Oox460YpGZw" dim="Surface" quantityType="0" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="FnHNSDTq3UO3NR5HNuiY_w" name="ColonTransversum_pls_ColonTransversum_int" description="Neighborhood between Large Intestine/Mucosa/Colon Transversum/Plasma and Large Intestine/Mucosa/Colon Transversum/Interstitial" mode="Logical" containerType="Other" firstNeighbor="j1XM0vRHAEaTiu2blg0NgQ" secondNeighbor="jMOo8Y0r2kymd4Qciv0Vvw">
-              <Tags>
-                <Tag value="ColonTransversum_pls_ColonTransversum_int" />
-                <Tag value="Large intestine  neighborhood" />
-                <Tag value="Neighborhood: Plasma / Interstitial" />
-              </Tags>
-              <Children>
-                <Container id="2dYVLmfBtUeT44jwlHVziw" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="yIYUVqp0A0qIouW-fvPLiw" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" formula="-DEFSC4vn0ajeww6-OP5eg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="KiGiwL5YwUq7IKT7mvfFjw" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" formula="_OrDeEVJ5U2cg9wZCSdjVQ" dim="Velocity" quantityType="0" />
-                    <Transport id="oO3wsOLW2UuSWvBN8oYB_w" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Other" dimension="Dimensionless" formula="mqEn2jhpv0G7HqNk13T-UA" sourceAmount="SLgG3jH9c0WpTyMIPQBI2g" targetAmount="aiygZmKWoEGjGHg91OrE-A" />
-                  </Children>
-                </Container>
-                <Parameter id="3H2TAY8tNkuECxfl0U-02w" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" formula="M4YzcbPnBU2LZ7ovEOmJuA" dim="Surface" quantityType="0" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="nKhYzmtOxUqyEUAh0hUwUw" name="ColonTransversum_int_ColonTransversum_cell" description="Neighborhood between Large Intestine/Mucosa/Colon Transversum/Interstitial and Large Intestine/Mucosa/Colon Transversum/Intracellular" mode="Logical" containerType="Other" firstNeighbor="jMOo8Y0r2kymd4Qciv0Vvw" secondNeighbor="ajdb6xz_Z0eFXoBiRThZCA">
-              <Tags>
-                <Tag value="ColonTransversum_int_ColonTransversum_cell" />
-                <Tag value="Large intestine  neighborhood" />
-                <Tag value="Neighborhood: Interstitial / Intracellular" />
-              </Tags>
-              <Children>
-                <Container id="eIYoCCvKLk-lz6iciY9dKA" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="rVPq0VRsdketZ7w1xrF7yg" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="3-LEyoK2GEOuCEV2otw_AQ" dim="Velocity" quantityType="0" />
-                    <Parameter id="IPQXPOKLtEicOGueJUcwiQ" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="xQZ40Mn0s0Wf7QlpiyG1_w" dim="Velocity" quantityType="0" />
-                    <Parameter id="HGUg44huckmucOntsBHjOQ" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="DIQILkkEz06QbATD24Bttw" dim="Flow (volume)" quantityType="0" />
-                    <Parameter id="IdvdWXxSv0Cad8lrV8XRkg" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="GRkU-raPfUeXS_32oxTzjQ" dim="Flow (volume)" quantityType="0" />
-                    <Parameter id="N8ww9LBMPUmV7TSo8tCsgA" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="dthwHllLHEKPuuOX_14PKA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="S3yzNJb4kU6dQbfkPW5g-Q" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="lf-pfpLwREileuprTt-QIA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="uam-Ea-b_UOwknzPGzDazA" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" formula="Ffj_PAh2FUWo_Br8ZFO_aw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="2hWuhIOW6UOp5RpNXgpTNQ" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" formula="3cJBFwQjyUqzb_kQadzpHA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="AytWkI7XkkWNh_XrOaXoPw" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" formula="2_XVrQuJi0a9xveJ8sbz5g" dim="Dimensionless" quantityType="0" />
-                    <Transport id="R8RqC-oGX0CV8gxx_9xSoA" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Other" dimension="Dimensionless" formula="vQgz4aYWlkOfEHSUsG1X9A" sourceAmount="aiygZmKWoEGjGHg91OrE-A" targetAmount="V5etuBdFRkuq-Q1hP1f8zg" />
-                  </Children>
-                </Container>
-                <Parameter id="n1qJhI7Q6UKWRJrjsOIvwA" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" formula="8n24IYEzh0GJb6ExbY1-zw" dim="Surface" quantityType="0" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="Rr2cvsdKske-xxEja_PODw" name="ColonDescendens_pls_ColonDescendens_int" description="Neighborhood between Large Intestine/Mucosa/Colon Descendens/Plasma and Large Intestine/Mucosa/Colon Descendens/Interstitial" mode="Logical" containerType="Other" firstNeighbor="PJgrM6BcSUav3cqJRrmkNA" secondNeighbor="f7z66YOv_0Kv2m70sTfn_g">
-              <Tags>
-                <Tag value="ColonDescendens_pls_ColonDescendens_int" />
-                <Tag value="Large intestine  neighborhood" />
-                <Tag value="Neighborhood: Plasma / Interstitial" />
-              </Tags>
-              <Children>
-                <Container id="PcFboCdcqEqQRog6A-f6Ww" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="lCHYZJSp-0aFRK2f7oihhA" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" formula="bZKr_zA1VUaA3E5oqKmQ-Q" dim="Velocity" quantityType="0" />
-                    <Parameter id="p6SfRkmx3U2782esIE3mYg" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" formula="-DEFSC4vn0ajeww6-OP5eg" dim="Dimensionless" quantityType="0" />
-                    <Transport id="o8B5a6CqXkuTGwyCMxsSTg" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Other" dimension="Dimensionless" formula="GAlwzo8kq0a0Ta5DHRhHuw" sourceAmount="W3SdEs2fVUKbnj5EqVBLXw" targetAmount="CKyJxgj_J0aXIt90lAntLg" />
-                  </Children>
-                </Container>
-                <Parameter id="ZgEF37gerUiYhLH7yHI8bQ" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" formula="iWiS7dCDNkipPoQQ4MBPGg" dim="Surface" quantityType="0" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="_TPeMhmc2UKpJDMdDFYFmA" name="ColonDescendens_pls_ColonDescendens_bc" description="Neighborhood between Large Intestine/Mucosa/Colon Descendens/Plasma and Large Intestine/Mucosa/Colon Descendens/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="PJgrM6BcSUav3cqJRrmkNA" secondNeighbor="atTfkMp6oU6CKOflJP6z3w">
-              <Tags>
-                <Tag value="ColonDescendens_pls_ColonDescendens_bc" />
-                <Tag value="Large intestine  neighborhood" />
-                <Tag value="Neighborhood: Plasma / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="3n3qG6EXX0qvQX6TXPznHw" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Transport id="8Nco9APMPkK7RjK3v_WpXg" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Other" dimension="Dimensionless" formula="3sSKiMqQ5UyTHNpevUcp6Q" sourceAmount="W3SdEs2fVUKbnj5EqVBLXw" targetAmount="1EnMTQCxHkmgkxQCMDxj7Q" />
-                  </Children>
-                </Container>
-                <Parameter id="GpQ18FpOpUeTAx40F3l_zw" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" formula="jK18VfDB7UOtczct6yqN3A" dim="Surface" quantityType="0" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="oMBKMMQvgkO9hBdt2UeDkw" name="ColonDescendens_int_ColonDescendens_cell" description="Neighborhood between Large Intestine/Mucosa/Colon Descendens/Interstitial and Large Intestine/Mucosa/Colon Descendens/Intracellular" mode="Logical" containerType="Other" firstNeighbor="f7z66YOv_0Kv2m70sTfn_g" secondNeighbor="fhKVy0QUsU65lCWnp-XKEw">
-              <Tags>
-                <Tag value="ColonDescendens_int_ColonDescendens_cell" />
-                <Tag value="Large intestine  neighborhood" />
-                <Tag value="Neighborhood: Interstitial / Intracellular" />
-              </Tags>
-              <Children>
-                <Container id="BdbgBPYjeUe5lJ_8J3uAYA" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="AHsQWqz7JUerWoSYMg6uLQ" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="XKUrHw1vSE2ucocno0qfpg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="_UgOKQUKcEOrFUTDaW5ZIQ" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="Ldwh2BMnd0SeZ28DafrTsA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="wfhTV0RoSUWxitITpi3ZAw" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" formula="ujBvRljCEUSlW9rlv-gMQQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="mAAEZVsYx0CkVQOAYLmxcg" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" formula="3cJBFwQjyUqzb_kQadzpHA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="yMwp_K5jpk-bKtsIaGiPZA" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="GRkU-raPfUeXS_32oxTzjQ" dim="Flow (volume)" quantityType="0" />
-                    <Parameter id="lqE_OqcGLEWiyaIVHaOdKg" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="xQZ40Mn0s0Wf7QlpiyG1_w" dim="Velocity" quantityType="0" />
-                    <Parameter id="agCMT2J8BEavobvVicxJvQ" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="3-LEyoK2GEOuCEV2otw_AQ" dim="Velocity" quantityType="0" />
-                    <Parameter id="5Kytl082QE-Syn7_hlNVxA" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="DIQILkkEz06QbATD24Bttw" dim="Flow (volume)" quantityType="0" />
-                    <Parameter id="4XOrH7RNwU2jpwdecG7QVA" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" formula="2_XVrQuJi0a9xveJ8sbz5g" dim="Dimensionless" quantityType="0" />
-                    <Transport id="1fisfXtcLUGnJ5IYQdoJeQ" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Other" dimension="Dimensionless" formula="JH9i_QXrL0q0E_TcaRKCRw" sourceAmount="CKyJxgj_J0aXIt90lAntLg" targetAmount="mEKZGg1cwkGlW7LIRKyu3Q" />
-                  </Children>
-                </Container>
-                <Parameter id="VhZh9KkduUWjQI8tHpVyMw" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" formula="jboZ7pXze0CCBPFxdWEuBg" dim="Surface" quantityType="0" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="HcxfNtS7iEmLsrRyI8ZZ-Q" name="ColonSigmoid_pls_ColonSigmoid_int" description="Neighborhood between Large Intestine/Mucosa/Colon Sigmoid/Plasma and Large Intestine/Mucosa/Colon Sigmoid/Interstitial" mode="Logical" containerType="Other" firstNeighbor="OueVYReP4UKcfdpQe9-xDg" secondNeighbor="tp-AgqcxjUix4Bk1CBNHOA">
-              <Tags>
-                <Tag value="ColonSigmoid_pls_ColonSigmoid_int" />
-                <Tag value="Large intestine  neighborhood" />
-                <Tag value="Neighborhood: Plasma / Interstitial" />
-              </Tags>
-              <Children>
-                <Container id="ttPjDZQsO0qynKxInR_SKg" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="d8a6Yx_qZ0KKjaEY-meVHA" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" formula="qZO0uDtGV0m7MXiF6uUVpA" dim="Velocity" quantityType="0" />
-                    <Parameter id="BlBYB74k_kKhJKCIH9jDtA" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" formula="-DEFSC4vn0ajeww6-OP5eg" dim="Dimensionless" quantityType="0" />
-                    <Transport id="8l2Vqz6EZE-cYmB5gq9aiA" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Other" dimension="Dimensionless" formula="x1FhOYMI2kiTel29J_lzHw" sourceAmount="Ecj_rn201Uq4oPkYy48ZIA" targetAmount="Mn9QFm9qE0SmdJIL6qjaHg" />
-                  </Children>
-                </Container>
-                <Parameter id="PbwG2AC1qk2RbUYb6UdVxg" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" formula="g6lR0tDIkE6EqlB6x3iyUQ" dim="Surface" quantityType="0" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="N3nA4mgN8Ey7o5kzX4Zgkw" name="ColonSigmoid_pls_ColonSigmoid_bc" description="Neighborhood between Large Intestine/Mucosa/Colon Sigmoid/Plasma and Large Intestine/Mucosa/Colon Sigmoid/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="OueVYReP4UKcfdpQe9-xDg" secondNeighbor="VFAajW768UeoKlpXQfnVNA">
-              <Tags>
-                <Tag value="ColonSigmoid_pls_ColonSigmoid_bc" />
-                <Tag value="Large intestine  neighborhood" />
-                <Tag value="Neighborhood: Plasma / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="xcIBEdYuAEqoC7E-sOyy-Q" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Transport id="ctKoYBxTPUeqKTwm4m5Nlg" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Other" dimension="Dimensionless" formula="nqzZ6uVvL02YPOsXysLVWQ" sourceAmount="Ecj_rn201Uq4oPkYy48ZIA" targetAmount="bftHsV58IEij5P2Nw6mjNA" />
-                  </Children>
-                </Container>
-                <Parameter id="oZwIWQqNREeuOctVNB6jAQ" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" formula="4BsuvIW3nEag7aD4jWhyJw" dim="Surface" quantityType="0" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="DuNyimk340WiXdamGz5H0Q" name="ColonSigmoid_int_ColonSigmoid_cell" description="Neighborhood between Large Intestine/Mucosa/Colon Sigmoid/Interstitial and Large Intestine/Mucosa/Colon Sigmoid/Intracellular" mode="Logical" containerType="Other" firstNeighbor="tp-AgqcxjUix4Bk1CBNHOA" secondNeighbor="S-Xf7WF0J0CfyWoC5jZgyQ">
-              <Tags>
-                <Tag value="ColonSigmoid_int_ColonSigmoid_cell" />
-                <Tag value="Large intestine  neighborhood" />
-                <Tag value="Neighborhood: Interstitial / Intracellular" />
-              </Tags>
-              <Children>
-                <Container id="L86GcK3ZS0-0Gj2PmEwqXA" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="Yyxb7DZdAEuywv5LxPrc_w" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="DIQILkkEz06QbATD24Bttw" dim="Flow (volume)" quantityType="0" />
-                    <Parameter id="CAOz_fyOFkqdTIJRS_OTCQ" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="GRkU-raPfUeXS_32oxTzjQ" dim="Flow (volume)" quantityType="0" />
-                    <Parameter id="KmtDKiE82kOHWYdI-hECCg" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="TVyTtwMj_EaF8y7e1f0fNw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="nCbwXwYYpUewZ6TjxalQmw" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="VSSYNk0Jw02htR8C2R2qwg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="6Sdl7G64j0ekjegpUiqUMA" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" formula="cyKQa287VEq5v9pKlUuxsg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="z2VP_jBr-kaVOCP8bDAvjg" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" formula="3cJBFwQjyUqzb_kQadzpHA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="9i56okh0CkCQMMvkSNOMgQ" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="xQZ40Mn0s0Wf7QlpiyG1_w" dim="Velocity" quantityType="0" />
-                    <Parameter id="ocij6yN7gkSPvxdmx3qQUA" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="3-LEyoK2GEOuCEV2otw_AQ" dim="Velocity" quantityType="0" />
-                    <Parameter id="A-uG9oGdlEaCSHVoLVG3rw" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" formula="2_XVrQuJi0a9xveJ8sbz5g" dim="Dimensionless" quantityType="0" />
-                    <Transport id="bvm2eIlZJ06Cu4gnNLoU2A" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Other" dimension="Dimensionless" formula="CXaxF0PLbEiXRxdFnhzrcw" sourceAmount="Mn9QFm9qE0SmdJIL6qjaHg" targetAmount="Q3pUr_-iP0yK59PkKUaZsA" />
-                  </Children>
-                </Container>
-                <Parameter id="lZcWa9UJik6qoRrQ9QkFgw" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" formula="WEJfg_j6JEOn1MCxHyy_Zg" dim="Surface" quantityType="0" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="SvewmdOvN0qQd4DSOfFKEQ" name="Rectum_int_Rectum_cell" description="Neighborhood between Large Intestine/Mucosa/Rectum/Interstitial and Large Intestine/Mucosa/Rectum/Intracellular" mode="Logical" containerType="Other" firstNeighbor="8Dqh8-N8EkePTw3n4M3mxA" secondNeighbor="HFtHaV0v7kCC7nIjLb3r1w">
-              <Tags>
-                <Tag value="Rectum_int_Rectum_cell" />
-                <Tag value="Large intestine  neighborhood" />
-                <Tag value="Neighborhood: Interstitial / Intracellular" />
-              </Tags>
-              <Children>
-                <Container id="s-pEcBODEESOxM892Hjiog" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="hX0LJfbtBkaDqlZeSxgR7Q" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="LAxO62QrGUavGrnEEz6H8w" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="Tyhj2M7cbkSre4-1FIlufw" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="xQZ40Mn0s0Wf7QlpiyG1_w" dim="Velocity" quantityType="0" />
-                    <Parameter id="wEumT13hCk-KRz5L4BZvRw" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="3-LEyoK2GEOuCEV2otw_AQ" dim="Velocity" quantityType="0" />
-                    <Parameter id="mlWy6UXT_E-SWOZ-v7tEZw" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" persistable="0" isFixedValue="0" formula="DIQILkkEz06QbATD24Bttw" dim="Flow (volume)" quantityType="0" />
-                    <Parameter id="kk0HlEBhDkCBTqInqF_Cbw" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="gKI09aGiLE2SHHSXn_a-TA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="vC-Mn--w50yM8NOidAHceg" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" formula="mnlXMUcSHEGeNbWx64VXiQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="bZjvkIi350GZEJ9kMvloUQ" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" formula="3cJBFwQjyUqzb_kQadzpHA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="A5DOS-DO3kqvEN1DricPZw" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" persistable="0" isFixedValue="0" formula="GRkU-raPfUeXS_32oxTzjQ" dim="Flow (volume)" quantityType="0" />
-                    <Parameter id="gyviPz-zUUGqMZDfuMEyow" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" formula="2_XVrQuJi0a9xveJ8sbz5g" dim="Dimensionless" quantityType="0" />
-                    <Transport id="hF7jkoPty0WCeU6ySqqblw" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Other" dimension="Dimensionless" formula="lznNPRu_CU2wOvMCtGH4NA" sourceAmount="dcxjau0F-0mHsNJQ4m5WSQ" targetAmount="Q-WHhoDEmkCqkRQKuB9hMQ" />
-                  </Children>
-                </Container>
-                <Parameter id="5FIzKvOP_UytoDg_8zOmHQ" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" persistable="0" isFixedValue="0" formula="HFWHjb_lY0OuXwYJqIYrYg" dim="Surface" quantityType="0" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="IIHYYFrtpUWhlduxYlUCVQ" name="Rectum_pls_Rectum_bc" description="Neighborhood between Large Intestine/Mucosa/Rectum/Plasma and Large Intestine/Mucosa/Rectum/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="zhw7k9aVu0eeZFACLC99xw" secondNeighbor="MFTNPY8lYUuHI3TkYqAe_Q">
-              <Tags>
-                <Tag value="Rectum_pls_Rectum_bc" />
-                <Tag value="Large intestine  neighborhood" />
-                <Tag value="Neighborhood: Plasma / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="1WAZkxTWGEO142i0Rq-zlQ" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Transport id="6BoAuENsx0aGlbZ6zAuQYw" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Other" dimension="Dimensionless" formula="q_ZLk_C48k6VMALbyliq6A" sourceAmount="r7ItQnvBJ0efZqobBY36mQ" targetAmount="bw0eSCTFWkiTM1Eimt2DBQ" />
-                  </Children>
-                </Container>
-                <Parameter id="3ziwcYTf4kycYH8CW9kX8g" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" persistable="0" isFixedValue="0" formula="ricXU2CQA0mmzVD32a7JxQ" dim="Surface" quantityType="0" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="qcyd-Pm3C0K0WjnoafZUpA" name="Rectum_pls_Rectum_int" description="Neighborhood between Large Intestine/Mucosa/Rectum/Plasma and Large Intestine/Mucosa/Rectum/Interstitial" mode="Logical" containerType="Other" firstNeighbor="zhw7k9aVu0eeZFACLC99xw" secondNeighbor="8Dqh8-N8EkePTw3n4M3mxA">
-              <Tags>
-                <Tag value="Rectum_pls_Rectum_int" />
-                <Tag value="Large intestine  neighborhood" />
-                <Tag value="Neighborhood: Plasma / Interstitial" />
-              </Tags>
-              <Children>
-                <Container id="MH5m7QikUkK1T7m-N7CcBQ" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="onLPBiN6pkeftgZ240To6g" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" persistable="0" isFixedValue="0" formula="NJiN9sdCnUqbCId0Njpppw" dim="Velocity" quantityType="0" />
-                    <Parameter id="g96FXaR4iECSTTWfbbLgXg" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" persistable="0" isFixedValue="0" formula="-DEFSC4vn0ajeww6-OP5eg" dim="Dimensionless" quantityType="0" />
-                    <Transport id="vcT0CqYluk-V606LqrjDXg" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Other" dimension="Dimensionless" formula="w-S-ovTVJEGudVnP4ZA-Tw" sourceAmount="r7ItQnvBJ0efZqobBY36mQ" targetAmount="dcxjau0F-0mHsNJQ4m5WSQ" />
-                  </Children>
-                </Container>
-                <Parameter id="G-WFr0zstU-yBKE2K257GA" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" persistable="0" isFixedValue="0" formula="OLGn0E3WGEeZJg3FkkyHnQ" dim="Surface" quantityType="0" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="YqcZwoFmUUefZqWP-nNOag" name="ColonTransversum_pls_PortalVein_pls" description="Neighborhood between Colon Transversum/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="j1XM0vRHAEaTiu2blg0NgQ" secondNeighbor="t3RJcRrWZk6Yk-_IRw-vvA">
-              <Tags>
-                <Tag value="ColonTransversum_pls_PortalVein_pls" />
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="-Hb1-QzjB0SkEqJ1YxEq9w" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="EUYYNclxLkuz45dLV6aWrw" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" persistable="0" isFixedValue="0" formula="_m16QDJYQEWw-l4UuJ9Gcw" dim="Rate" quantityType="0" />
-                    <Transport id="2YcH5GLbwE-SwwYo3PAzzw" name="MassTransferMucosaToPvePlasma" description="Mass transfer from Mucosa:Plasma To Portal Vein: Plasma" mode="Logical" containerType="Other" dimension="Dimensionless" formula="2AN731uhVkyUrcNottvoSQ" sourceAmount="SLgG3jH9c0WpTyMIPQBI2g" targetAmount="3epVIeHC_0m65IYsJjSaDQ" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="8GhAQN0NjU62kULSCxOC9g" name="Lumen_colsigm_ColonSigmoid_cell" description="Neighborhood between Lumen/Colon Sigmoid and Mucosa/Colon Sigmoid/Intracellular" mode="Logical" containerType="Other" firstNeighbor="t9buGgr6O02MMqVEqnLjgQ" secondNeighbor="S-Xf7WF0J0CfyWoC5jZgyQ">
-              <Tags>
-                <Tag value="Lumen_colsigm_ColonSigmoid_cell" />
-                <Tag value="Neighborhood: ColonSigmoid / Intracellular" />
-              </Tags>
-              <Children>
-                <Container id="DSk0UZ5C8kKGRMYQsob_jA" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="rLsRZIK3fkWxd55kER2aDg" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="wcCD8sEmTUKhyG0DxkCpug" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="lDxPttcYZU2Ot986q2vs2w" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="nsfLmi9rukK1neyDyO4JWA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="4ZJ4YM8tNkepkN31NSAvVg" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="wDa7xWeqUkiuTUmNBVb5Gw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="ImrMkhpC7kWdmZPf4aOgPQ" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" formula="LkPio2MLi0eYfy2YzeD7tw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="P-9Dy451806f96ltVCJUJw" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" formula="8SFD3k75nUS5-GEJBaKMUw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="m29n7z0qaEWBUS6WtmWVgw" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="S5rOyojRIUmpgOV6TPakRQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="lS1RgXwj1UCHneGueX43aA" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="RJRIddynfU-kStoSCNdNxQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="CtT2Baf7Mkengaaq-mkl2g" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" formula="z9HfD89DBkaYWMCL4UrAIA" dim="Rate" quantityType="0" />
-                    <Parameter id="eON2p3drcEuX8kv28ih9hw" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="xM7lqQL_aEy-cELqFKBf3w" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="mi_3J3SUUk-0N5ryPN_ybA" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="WFbKuaD2_Uut_BXIFvFxpA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="9LppXglZsEiV1ZZqQSvxYA" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="k8hWpEIpF0KjTAC5NbdvbA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="NeRDnMNVMEertB9nuCynGA" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="S_qjrFFhlUei9mGuxmLKJg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="gAvHu1u5hkiAWSGme-oQNQ" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="3uQ_8bks5kSiesc_SOfNwA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="-BAk_-ogbkKM9x-137wNOw" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="SzK_8omVIE-vZmY_eihelA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="AM3c0GlAo06zdJ5R55Adjg" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="Aw8vq5KCWEOCAoMQrVN6FQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="ZQ25SXf8TkmWQjWES67NEg" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="PdH_puI8x0SM-tI3E7CmgQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="aLe5rvOuHEqBgjUjRAfLoQ" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="aMN4XH4f10CaDLbJlRvOYg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="U3Tcawkc70yPdeBh00HgsQ" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="q3UCyneZi0CZtpN2SylR9A" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="-ZHFmf33n0eGUeANhkyQ9g" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="bgwCgnpvPEW0kYAXw9hA1A" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="9RMmKnnRp02NU1JU--BnmA" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="qLfPuK6VKkWZprZs_F5v3w" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="H9jcW98RAkunC5IupVaCcg" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="_naC9VdnpkS6SojBAHGu4A" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="S0bvB-2kYUCZC_4EAqu5vA" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="AkRbpFWVBEe9u5MbHZxalg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="P8qEEc1f2UiNH-THKgI1NA" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="Kf9Bxa2_b0Geq1rJPr-UGQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="A_6XdqNPykSpMcTXuaCDnw" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="F6FIReabwUqeLEL5fA8UaA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="8GWKhTiNVkq09To02GBMzg" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="QWN9mrAel0-mdjkWIwyAtw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="nUj4Znb1ZEqHi76s3iMlTw" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="AAnDqAX9zUqoNDW37i4yBQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="ZLGv0lgdDEusbJ2FnFFXKg" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="aJba9lRteUSyHr8r46GXyw" dim="Dimensionless" quantityType="0" />
-                    <Transport id="2uQTJ4nsRkehkaLcp0uy7g" name="DrugAbsorption_trans" description="Drug absorption transcellular" mode="Logical" containerType="Other" dimension="Dimensionless" formula="If33rPOQNkOoJHE1H5H1BQ" sourceAmount="zyEivk-9f02yySFoyDYMYQ" targetAmount="Q3pUr_-iP0yK59PkKUaZsA" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="WCeaUqRW9EWzPDGnMTTu2g" name="Caecum_bc_PortalVein_bc" description="Neighborhood between Cecum/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="z3nIn6C3j0yVWC-W8t3Ztg" secondNeighbor="UsK_koflU0aP-ubDRlslJQ">
-              <Tags>
-                <Tag value="Caecum_bc_PortalVein_bc" />
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="cxQ0Ko6ct0OelOjJtEk1_A" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="Pr_I9g0Fv0GhDp0odMagVg" name="Mass transfer rate (mucosa to portal vein blood cells)" description="Mass transfer rate (mucosa to portal vein blood cells)" persistable="0" isFixedValue="0" formula="kUjXWKBS0kyQOLx--Jtj9w" dim="Rate" quantityType="0" />
-                    <Transport id="cJJ0zyf9WkiqPAX43rzs7Q" name="MassTransferMucosaToPveBC" description="Mass transfer from Mucosa:Blood Cells To Portal Vein: Blood Cells" mode="Logical" containerType="Other" dimension="Dimensionless" formula="OCKdv4MvOUqriBDkPxTFkA" sourceAmount="Bdz3BSeKVE6ApvHc1Oikmg" targetAmount="F8UZepNEFEqiqDVPY4DDnA" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="pJkeACXr-0SCKqyzkw6c4w" name="Lumen_colasc_ColonAscendens_pls" description="Neighborhood between Lumen/Colon Ascendens and Mucosa/Colon Ascendens/Plasma" mode="Logical" containerType="Other" firstNeighbor="zUyNSXS6uEitLMuf2-ef3Q" secondNeighbor="BkigLfGvSkiooZ67DLK2NQ">
-              <Tags>
-                <Tag value="Lumen_colasc_ColonAscendens_pls" />
-                <Tag value="Neighborhood: ColonAscendens / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="9c0b2eORrUquATKcVKvMoA" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="RJjJV95lCkCHaeteat-Phg" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" formula="HDjQSqp360-Loqi08gLFgg" dim="Rate" quantityType="0" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="U2yuduMSVUO-IHUcTPu2Gg" name="Lumen_colasc_ColonAscendens_cell" description="Neighborhood between Lumen/Colon Ascendens and Mucosa/Colon Ascendens/Intracellular" mode="Logical" containerType="Other" firstNeighbor="zUyNSXS6uEitLMuf2-ef3Q" secondNeighbor="iBBpeGvAM0mWO2YbgWcZFw">
-              <Tags>
-                <Tag value="Lumen_colasc_ColonAscendens_cell" />
-                <Tag value="Neighborhood: ColonAscendens / Intracellular" />
-              </Tags>
-              <Children>
-                <Container id="7wGJ6p0T-EuzOmHxvbNZGg" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="ht6BTEdbzkCZffDAjvl6sQ" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="F6FIReabwUqeLEL5fA8UaA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="V0rQROyobkWicUrzX4MBtw" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="aJba9lRteUSyHr8r46GXyw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="X5oUpQbDXkaiIWDZOI54WQ" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="3uQ_8bks5kSiesc_SOfNwA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="MOXDpLd7lU-7d2E9e79S_g" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="k8hWpEIpF0KjTAC5NbdvbA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="6oBdWbnxEEOCPFcGIoIBAg" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="SzK_8omVIE-vZmY_eihelA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="0JIO4sU2C0yQ8IWZgag7cg" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="Aw8vq5KCWEOCAoMQrVN6FQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="4KUVkaGFQ0W33ANl8Tj-mQ" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="PdH_puI8x0SM-tI3E7CmgQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="daD2EjIYrkW6f7R2XXhmjw" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="aMN4XH4f10CaDLbJlRvOYg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="fSadMRSO0UOBGSzN5f7tVw" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="q3UCyneZi0CZtpN2SylR9A" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="gfFKQujB0UaGn1-6h-IAIg" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="Vs4LFEHiykSGO-_HxipmtQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="bRi41c93eEOcYCjvPWBxgg" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="SpfVa6tT50WgRQREp_L5pg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="wsLrMf97R0iXMBr_vHH6nw" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="IkRvLa17QU-axlQ_makHhg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="TbdGJkNSCU-J6u2hURQdBQ" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="Kf9Bxa2_b0Geq1rJPr-UGQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="NyHkOLLXj0-8iZNAPRi1ag" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="QWN9mrAel0-mdjkWIwyAtw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="jzmixUKZfkG4JzOvedFrTQ" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="AAnDqAX9zUqoNDW37i4yBQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="VBOoJC1Sy0aob3XnPbXE9g" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="WFbKuaD2_Uut_BXIFvFxpA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="vXjiZfcAyUmcqmADOcELKg" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="xM7lqQL_aEy-cELqFKBf3w" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="aA6vBhtrJUSG1xb3ZETEiw" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="S_qjrFFhlUei9mGuxmLKJg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="AQ-7P98VEUKppUiTDSKW7Q" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="3IG_AlQC0UO3AaVQBnmIfQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="5LJaKkjV6kiHNINYV7vFuw" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="1TyEQhA3u0qE8p0J3oORpw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="9g4dGotLfEGI0cc-39W-Vw" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="J5SNhcxQ30qjLr2XWPiz0g" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="hNyqaYmPhUa2MDeSdTPFpg" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" formula="RS-XpwlACUCPrguVuL_j5w" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="5vD4zoYkyESsDCmbbe2sJw" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" formula="5dduWcQe1Uate0BKSWv6ew" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="_ptHqMUoL0GgQEMPEeqlMA" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="S5rOyojRIUmpgOV6TPakRQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="Za-7QW51KEGzQ6x08Xjz6g" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="RJRIddynfU-kStoSCNdNxQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="iH0lyJliLEuRZYjDkoPUBg" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" formula="xw_7OJag1EKfPSmZwZBdXw" dim="Rate" quantityType="0" />
-                    <Parameter id="Ut4PtQINB02gqomvvNR1vw" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="AkRbpFWVBEe9u5MbHZxalg" dim="Dimensionless" quantityType="0" />
-                    <Transport id="nnVR4jtKNUu0lSIoAY0DnQ" name="DrugAbsorption_trans" description="Drug absorption transcellular" mode="Logical" containerType="Other" dimension="Dimensionless" formula="MPhJNT-Y70GpJBS5zsbzpw" sourceAmount="jyt3cPowb0KjcfkF_O9aLA" targetAmount="xnxvY69E7EKFACGGZTKgzg" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="bnXJrtFzA0WOnLC7OFZs_Q" name="ColonAscendens_pls_PortalVein_pls" description="Neighborhood between Colon Ascendens/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="BkigLfGvSkiooZ67DLK2NQ" secondNeighbor="t3RJcRrWZk6Yk-_IRw-vvA">
-              <Tags>
-                <Tag value="ColonAscendens_pls_PortalVein_pls" />
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="LznjP8_e1EyQexbwjjhUVQ" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="FqKBJYE5BEqq3bna6Uo-lA" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" persistable="0" isFixedValue="0" formula="ZRmd5YOf20CrnN_xGffGkg" dim="Rate" quantityType="0" />
-                    <Transport id="JfqCfpUXIEm1rO9yOFV2Gw" name="MassTransferMucosaToPvePlasma" description="Mass transfer from Mucosa:Plasma To Portal Vein: Plasma" mode="Logical" containerType="Other" dimension="Dimensionless" formula="B8jv2QUePkeHpb8BClwDMg" sourceAmount="6ewOCi0jbU6RbncNeaX1hw" targetAmount="3epVIeHC_0m65IYsJjSaDQ" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="KRwfFwkcEUOXcBXbZgr0zA" name="ColonAscendens_bc_PortalVein_bc" description="Neighborhood between Colon Ascendens/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="aBWYhB1S5EmhC-3vnT5kZg" secondNeighbor="UsK_koflU0aP-ubDRlslJQ">
-              <Tags>
-                <Tag value="ColonAscendens_bc_PortalVein_bc" />
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="FB4a7lUQh0Sr7N6sxjaVQQ" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="3-5FrRe4qU2wrSSkXr1wrA" name="Mass transfer rate (mucosa to portal vein blood cells)" description="Mass transfer rate (mucosa to portal vein blood cells)" persistable="0" isFixedValue="0" formula="ylRQTS1pKUabRDeFWXuA3Q" dim="Rate" quantityType="0" />
-                    <Transport id="QoVokbnCXU2Q-5FU1yUZ-w" name="MassTransferMucosaToPveBC" description="Mass transfer from Mucosa:Blood Cells To Portal Vein: Blood Cells" mode="Logical" containerType="Other" dimension="Dimensionless" formula="wBDHwlBR4EKOdjA8OsayjQ" sourceAmount="2LtEnxRQ-E68v82BoICp1A" targetAmount="F8UZepNEFEqiqDVPY4DDnA" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="dYvqgXiQskmoPAZxzJDchQ" name="Lumen_cae_Caecum_cell" description="Neighborhood between Lumen/Cecum and Mucosa/Cecum/Intracellular" mode="Logical" containerType="Other" firstNeighbor="hnrXLSFg2E-aaJshK4BODA" secondNeighbor="owoyJrHWdkm0XLbwyDZ8rQ">
-              <Tags>
-                <Tag value="Lumen_cae_Caecum_cell" />
-                <Tag value="Neighborhood: Caecum / Intracellular" />
-              </Tags>
-              <Children>
-                <Container id="pSvEkFlP80uUw14q9gsMZg" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="7pjzW1Vf20Ci078YUnuOPA" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" formula="B1VCxuKqn0OdKj3DlhhmxQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="GIwnebqtv0W39owQwWKp3Q" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" formula="AYkpgQH6HE2MT8qLMNNOYQ" dim="Rate" quantityType="0" />
-                    <Parameter id="217yBel9fUSNjsmQyZEDwA" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="RJRIddynfU-kStoSCNdNxQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="YIQ3LKaJ_ku3vYv_snxekQ" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="S5rOyojRIUmpgOV6TPakRQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="oFTfYus_ukWzwuXrrpPcaw" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" formula="V76GBP5BPEaNX_ctYQtL5w" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="u3tDrgS8FUWKWKO_j_6cUA" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="nPbXkMsKm0qXAnwrnicjwg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="Lc_RghKFiU6sKrJl4D3-Fg" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="q3UCyneZi0CZtpN2SylR9A" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="TXes6G70oUKutsaz2MeVhg" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="aJba9lRteUSyHr8r46GXyw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="2PfDFFxjz0a7mZmtRxSF0Q" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="3uQ_8bks5kSiesc_SOfNwA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="umZKKlsdmEiM9CtzDFCH6Q" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="k8hWpEIpF0KjTAC5NbdvbA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="gnqAmsAHHka24Hem8f59Rg" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="SzK_8omVIE-vZmY_eihelA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="DEqYAXiZC0GD2LSUivRf2A" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="Aw8vq5KCWEOCAoMQrVN6FQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="QFVDH_gqWUWx-COj7mNQDA" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="aMN4XH4f10CaDLbJlRvOYg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="kr1wZSky1kGPtJ2OIDD88A" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="pH8YyDg-Q0-Ahp3vwSvUBA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="8o7gQ3HtR02WRfwdr1n-2g" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="8wmHnmjjG0WfmTYHtYY6WQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="CKwQU4Q59kmDbu4lg2LmWg" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="BV9CGH2rfEuGQbN0yEUMeQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="WPNE5iUB5keK34JOiGPR3g" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="AkRbpFWVBEe9u5MbHZxalg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="eEFl-DPUcEy_2arG6sB_PQ" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="Kf9Bxa2_b0Geq1rJPr-UGQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="rfZ1bw2iKEyIhaS4xIspow" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="F6FIReabwUqeLEL5fA8UaA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="E2TFSWagTE6HYGRWMZLfUw" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="QWN9mrAel0-mdjkWIwyAtw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="nnpR4ZarWU6Z3Mgp-lKmLw" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="AAnDqAX9zUqoNDW37i4yBQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="VleDXCwyFka2END47gBYrw" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="WFbKuaD2_Uut_BXIFvFxpA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="aiUszwrhoUqdq1NTZZ2PGg" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="xM7lqQL_aEy-cELqFKBf3w" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="BwB69W_V_0ikJI4AFV5TTg" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="S_qjrFFhlUei9mGuxmLKJg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="4QNJ9ZmnKkmKVa5aXB51ew" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="uC6jdto_RUq06Om6NrDIVw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="tR-wnWkx2EWo-GQPNJZvdw" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="xuPXxNDI30eIpxyXQSe5gA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="eIJgjsNGw0iNxHMLR_gXYg" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="PdH_puI8x0SM-tI3E7CmgQ" dim="Dimensionless" quantityType="0" />
-                    <Transport id="fSx1dKWAB0-OhKlli74fcQ" name="DrugAbsorption_trans" description="Drug absorption transcellular" mode="Logical" containerType="Other" dimension="Dimensionless" formula="HqeR29sXrU6bVRBsWkW1uA" sourceAmount="MnNILc-ThEuWb2MmUdz8QQ" targetAmount="wCOP5C6iSUaesCPdCtMtCg" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="2de0CZsfwUWthfRHJVGOlQ" name="Lumen_coltrans_ColonTransversum_cell" description="Neighborhood between Lumen/Colon Transversum and Mucosa/Colon Transversum/Intracellular" mode="Logical" containerType="Other" firstNeighbor="Rs3PRJYB9UKcgdddhyZaZg" secondNeighbor="ajdb6xz_Z0eFXoBiRThZCA">
-              <Tags>
-                <Tag value="Lumen_coltrans_ColonTransversum_cell" />
-                <Tag value="Neighborhood: ColonTransversum / Intracellular" />
-              </Tags>
-              <Children>
-                <Container id="HygfJd9yeUGFEaJh0GBKMw" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="6dEUx7ma2kupW-f9x6ZBwQ" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="UTnvuBJ_iUi3LQzWmKeETg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="IP8RWkcH-UyhNCQZ8Q9sIA" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="aMN4XH4f10CaDLbJlRvOYg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="MuwnL_uzxE20DyfMRx4gzQ" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="q3UCyneZi0CZtpN2SylR9A" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="21ZzDEu37EO6M0R8j3sZgA" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="7AaTslTFTEysISSmGaAFgg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="Otg2gysZfUK2pTsy4m45ZQ" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="H4JNWKUpx0-HWnHG8UXulg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="kHllvevQVEOHvfN_uuRj8w" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="h94I4ISHWEyelfXeo_KI5Q" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="mmypFNRVY0GeR_muTdpeIQ" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="AkRbpFWVBEe9u5MbHZxalg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="7gMDi_u4SUG4Ck6xgY_Few" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="Kf9Bxa2_b0Geq1rJPr-UGQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="WzFBNK9LQUqvazqCMq-DSw" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="F6FIReabwUqeLEL5fA8UaA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="Jzo9CSLU70ypgA7CUTUiuA" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="QWN9mrAel0-mdjkWIwyAtw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="EKU78YZsGk27vdoxeBwk0w" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="AAnDqAX9zUqoNDW37i4yBQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="7GBXvQnsckabzVjqgeAXhg" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="WFbKuaD2_Uut_BXIFvFxpA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="RUsohMwWD0eDdzO3tW227g" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="xM7lqQL_aEy-cELqFKBf3w" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="oiDskhxVkkmJ7xlGHLcXfA" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="vvQ-sLG9p0SMb7yctbZFSA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="eytb-d5IQ0qSNFUWikSS0w" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="SzK_8omVIE-vZmY_eihelA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="uS_2RYqmeEuIBDdJDC6itw" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="HDmFkkmgpkK00C3zKokliw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="n0P2QLzY802JgkZqN0fihA" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" formula="2ytDM6dfXE6bHMf0VOt17A" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="iYUEJmhu1km8EBFez4sC3w" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" formula="aRr9Y-V6S0yK1NhbDkjhng" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="x-OMhy_K0kWhqF3zhEuWvw" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="S5rOyojRIUmpgOV6TPakRQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="ns1LCAmxF02teMzrvHgMLA" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="RJRIddynfU-kStoSCNdNxQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="3lrFCp07jkaqV9NAfZi2Fg" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" formula="hWSi6d6b30C0u4DLwF11zg" dim="Rate" quantityType="0" />
-                    <Parameter id="sMIw5vB8_EmSc-Ru1D4Fow" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="S_qjrFFhlUei9mGuxmLKJg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="7Sjyxnn3502D2iPMeBSE_A" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="PdH_puI8x0SM-tI3E7CmgQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="E5D56zWXC0KMEnCxrW8w6A" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="Aw8vq5KCWEOCAoMQrVN6FQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="BTT2U7Rs10OIbtbgnSnOFA" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="aJba9lRteUSyHr8r46GXyw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="v94FHmZBY0SKkQceVEz7cg" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="3uQ_8bks5kSiesc_SOfNwA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="97WJ1ukjvE6DTs2kYwmbhQ" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="k8hWpEIpF0KjTAC5NbdvbA" dim="Dimensionless" quantityType="0" />
-                    <Transport id="eB-AWqG_IEuynwlesqwTzg" name="DrugAbsorption_trans" description="Drug absorption transcellular" mode="Logical" containerType="Other" dimension="Dimensionless" formula="OXDwBL4tSEmEdceweqc6eA" sourceAmount="bRBIqa0pgkWCj0_OcRNkPA" targetAmount="V5etuBdFRkuq-Q1hP1f8zg" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="trgpuXvQGE2mfXbiK6ZSag" name="Lumen_cae_Caecum_pls" description="Neighborhood between Lumen/Cecum and Mucosa/Cecum/Plasma" mode="Logical" containerType="Other" firstNeighbor="hnrXLSFg2E-aaJshK4BODA" secondNeighbor="l8icBJ2uN0KH4u_hLlRE-Q">
-              <Tags>
-                <Tag value="Lumen_cae_Caecum_pls" />
-                <Tag value="Neighborhood: Caecum / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="W30fhrGzxUKccJTa_XxvQA" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="TNAX7sUvlEufwpyTlfJfWA" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" formula="rq3QMpAX7EO5DnYcT437JQ" dim="Rate" quantityType="0" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="c2W2eEQP10uRjhPJSGV_AA" name="ColonTransversum_bc_PortalVein_bc" description="Neighborhood between Colon Transversum/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="4h08SDSRP0uZygWcIRA7mg" secondNeighbor="UsK_koflU0aP-ubDRlslJQ">
-              <Tags>
-                <Tag value="ColonTransversum_bc_PortalVein_bc" />
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="pbS4I8fJXEGQGOko4faJvw" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="EmVoodqruUGjyVKqZ0rGIw" name="Mass transfer rate (mucosa to portal vein blood cells)" description="Mass transfer rate (mucosa to portal vein blood cells)" persistable="0" isFixedValue="0" formula="erWf4NdPf0W1MoIH3fn4Ww" dim="Rate" quantityType="0" />
-                    <Transport id="fGPT6WVgSkWQzzsOwBTLjg" name="MassTransferMucosaToPveBC" description="Mass transfer from Mucosa:Blood Cells To Portal Vein: Blood Cells" mode="Logical" containerType="Other" dimension="Dimensionless" formula="hC52uv23E0aKZp0mlZohdA" sourceAmount="DQ3BvfhWu0maydUENsDylg" targetAmount="F8UZepNEFEqiqDVPY4DDnA" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="700tkdKix0mVVdRYJCHldQ" name="Lumen_coldesc_ColonDescendens_pls" description="Neighborhood between Lumen/Colon Descendens and Mucosa/Colon Descendens/Plasma" mode="Logical" containerType="Other" firstNeighbor="9jArwMBpW06x34mUf4QukQ" secondNeighbor="PJgrM6BcSUav3cqJRrmkNA">
-              <Tags>
-                <Tag value="Lumen_coldesc_ColonDescendens_pls" />
-                <Tag value="Neighborhood: ColonDescendens / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="oT2Rfj9SfUmctpEbX-EoaA" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="fsi4frPJYEi3LATjrAYIVA" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" formula="ODfAvtx5kkWUHnXBeKsncg" dim="Rate" quantityType="0" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="2av1VQeCP0iyf1DPJGUNSw" name="Lumen_coldesc_ColonDescendens_cell" description="Neighborhood between Lumen/Colon Descendens and Mucosa/Colon Descendens/Intracellular" mode="Logical" containerType="Other" firstNeighbor="9jArwMBpW06x34mUf4QukQ" secondNeighbor="fhKVy0QUsU65lCWnp-XKEw">
-              <Tags>
-                <Tag value="Lumen_coldesc_ColonDescendens_cell" />
-                <Tag value="Neighborhood: ColonDescendens / Intracellular" />
-              </Tags>
-              <Children>
-                <Container id="WwtzzsiFuk68Ok2KxOYEyQ" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="apew_jtd1UKoLFgTdOZ4pg" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="AkRbpFWVBEe9u5MbHZxalg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="ECCg2WQ5_U64r03Co_8TfA" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" formula="Zao02Ydk30G2OZSNGJ6dBQ" dim="Rate" quantityType="0" />
-                    <Parameter id="Ha-wC6gfvke8yepqvYYcmg" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="F6FIReabwUqeLEL5fA8UaA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="fJlWEQk70USQHf_Eg9N2tg" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="QWN9mrAel0-mdjkWIwyAtw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="cfUIAVu3-EqAkKdeAWkKGg" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="AAnDqAX9zUqoNDW37i4yBQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="d-hIgbGCak2DW0jJtzh9dg" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="WFbKuaD2_Uut_BXIFvFxpA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="OIE8nbKfPEu1XS02Qwnj5w" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="xM7lqQL_aEy-cELqFKBf3w" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="73_r62qxZE6ofLPATtec_w" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="S_qjrFFhlUei9mGuxmLKJg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="2CXnSueqZEemvyeMVVE4DA" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="_XMUQAuDVEeAZ9x0buQwiQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="NtG9fQOvykm_5UDVVcLenQ" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="2OvlhL5H5UG1Fh1olRvktw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="yONMUk-dEUK2DJGNLg_fbw" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="XgecxeOARkKxQelCfyRyRw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="M-RDHZYO-EuCrI3CC2fUPg" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" formula="Q-anDjKke0Od8qjNQcAcdA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="uSXOOCtpFkaix1mCxeOerw" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" formula="rYGnbCSFG0ua4M3dfXvKmg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="2bwIX_uP8UCHvNdo3c3piw" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="RJRIddynfU-kStoSCNdNxQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="lciZWaoiLU-tZkTqPPpK9A" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="S5rOyojRIUmpgOV6TPakRQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="27dQ4dpukkqhJJs_CJmJqA" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="vWrFxkSipEWpjAAEmXJy7Q" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="xMcJUs1h1UWxeqxN0_8f4g" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="Kf9Bxa2_b0Geq1rJPr-UGQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="gjOqP3Wss0uFKFRQYNqmNg" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="aJba9lRteUSyHr8r46GXyw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="Sj9KgH8UvE-WZSxu1JGSSA" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="3uQ_8bks5kSiesc_SOfNwA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="C-MHB3VJyU-aGtUmFyt7IQ" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="k8hWpEIpF0KjTAC5NbdvbA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="7V6NIdSJ-0CstsWrGt1H7w" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="SzK_8omVIE-vZmY_eihelA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="6cyLPh_ycUqnMfPRbjPDPw" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="Aw8vq5KCWEOCAoMQrVN6FQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="Hy1I-gKvAECYl9QVzbR_6Q" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="PdH_puI8x0SM-tI3E7CmgQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="evOOiGC7iUyP3EXwLm4ccQ" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="aMN4XH4f10CaDLbJlRvOYg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="oFjwBXz8JUW3_UcbAn6ktw" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="q3UCyneZi0CZtpN2SylR9A" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="Rv27i7B_jEa5O7uRw6JHPQ" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="z4FxhKt8sEC3YsXwQiET6A" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="EgVpmGJPDUySGh9kFhStDw" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="FC8vxccsWEiYhZxbgjEcVw" dim="Dimensionless" quantityType="0" />
-                    <Transport id="R7i11a7CY0ixI-EjnKYwOQ" name="DrugAbsorption_trans" description="Drug absorption transcellular" mode="Logical" containerType="Other" dimension="Dimensionless" formula="PV4R0ZCs3k-XcQfFDc81zQ" sourceAmount="NcJB6NUxaEGwgdsFjtyx4w" targetAmount="mEKZGg1cwkGlW7LIRKyu3Q" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="t6-ROLCE3EO86XSM97oHRA" name="ColonDescendens_pls_PortalVein_pls" description="Neighborhood between Colon Descendens/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="PJgrM6BcSUav3cqJRrmkNA" secondNeighbor="t3RJcRrWZk6Yk-_IRw-vvA">
-              <Tags>
-                <Tag value="ColonDescendens_pls_PortalVein_pls" />
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="BZVSFxWrA0mo-B5VEX_Pqg" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="bphovLO4UEW6-BnV_aMSGg" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" persistable="0" isFixedValue="0" formula="XZ0-fnxsb0Gbi5G7otxe7Q" dim="Rate" quantityType="0" />
-                    <Transport id="unuIoMgP70OcY8rdla63Bw" name="MassTransferMucosaToPvePlasma" description="Mass transfer from Mucosa:Plasma To Portal Vein: Plasma" mode="Logical" containerType="Other" dimension="Dimensionless" formula="uyAJLA1y-UGonASzkymDaw" sourceAmount="W3SdEs2fVUKbnj5EqVBLXw" targetAmount="3epVIeHC_0m65IYsJjSaDQ" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="vFwhideAekWeL3Y3k2-SAw" name="ColonDescendens_bc_PortalVein_bc" description="Neighborhood between Colon Descendens/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="atTfkMp6oU6CKOflJP6z3w" secondNeighbor="UsK_koflU0aP-ubDRlslJQ">
-              <Tags>
-                <Tag value="ColonDescendens_bc_PortalVein_bc" />
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="svX46MhNS0666JGfJ_ztXA" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="RQTutjS60EqJZXkJkPNGUg" name="Mass transfer rate (mucosa to portal vein blood cells)" description="Mass transfer rate (mucosa to portal vein blood cells)" persistable="0" isFixedValue="0" formula="YhwY90gbBE2bShPcR_hmRA" dim="Rate" quantityType="0" />
-                    <Transport id="ickf-XIQLk6NSzfB3DB4nw" name="MassTransferMucosaToPveBC" description="Mass transfer from Mucosa:Blood Cells To Portal Vein: Blood Cells" mode="Logical" containerType="Other" dimension="Dimensionless" formula="hcTBFsHEp0-txGcgomUo8A" sourceAmount="1EnMTQCxHkmgkxQCMDxj7Q" targetAmount="F8UZepNEFEqiqDVPY4DDnA" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="_Gc8qKGYNUSM8pkErHBGVA" name="Lumen_coltrans_ColonTransversum_pls" description="Neighborhood between Lumen/Colon Transversum and Mucosa/Colon Transversum/Plasma" mode="Logical" containerType="Other" firstNeighbor="Rs3PRJYB9UKcgdddhyZaZg" secondNeighbor="j1XM0vRHAEaTiu2blg0NgQ">
-              <Tags>
-                <Tag value="Lumen_coltrans_ColonTransversum_pls" />
-                <Tag value="Neighborhood: ColonTransversum / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="1bm02joVMECZFWJwmxbPCA" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="z9Pjb3TMzEKEkeukEujqAA" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" formula="bvZRIT8FtEigllVHDC8kZQ" dim="Rate" quantityType="0" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="lEwb9xD11k-ictF17TRO0w" name="Caecum_pls_PortalVein_pls" description="Neighborhood between Cecum/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="l8icBJ2uN0KH4u_hLlRE-Q" secondNeighbor="t3RJcRrWZk6Yk-_IRw-vvA">
-              <Tags>
-                <Tag value="Caecum_pls_PortalVein_pls" />
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="b4m3PO0FL0CwJXcJR8I8aQ" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="3Vq5YCsiJECcWL0PSvUD6w" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" persistable="0" isFixedValue="0" formula="ym1bSwlkUUeO69V2HoSrvg" dim="Rate" quantityType="0" />
-                    <Transport id="O-VQ5BE0Vk6kubgCaVs-Mg" name="MassTransferMucosaToPvePlasma" description="Mass transfer from Mucosa:Plasma To Portal Vein: Plasma" mode="Logical" containerType="Other" dimension="Dimensionless" formula="u8eyyiw690OfUj_ZCFSfzg" sourceAmount="0BQVZSFbd0yvGdZJo-TkmQ" targetAmount="3epVIeHC_0m65IYsJjSaDQ" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="sUlm8tJAjUupfcikm3iwKQ" name="ColonSigmoid_pls_PortalVein_pls" description="Neighborhood between Colon Sigmoid/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="OueVYReP4UKcfdpQe9-xDg" secondNeighbor="t3RJcRrWZk6Yk-_IRw-vvA">
-              <Tags>
-                <Tag value="ColonSigmoid_pls_PortalVein_pls" />
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="vQLMo2u7oE2aAEr99m0B7A" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="b_gY4STVoEeucoORoJ_bXA" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" persistable="0" isFixedValue="0" formula="xXRbU18Gikm5A-X0UKP5Lw" dim="Rate" quantityType="0" />
-                    <Transport id="cFXb_9H8JEmYdPqEKKWgag" name="MassTransferMucosaToPvePlasma" description="Mass transfer from Mucosa:Plasma To Portal Vein: Plasma" mode="Logical" containerType="Other" dimension="Dimensionless" formula="1qc43JvaK0iYwdBZ5QIVWA" sourceAmount="Ecj_rn201Uq4oPkYy48ZIA" targetAmount="3epVIeHC_0m65IYsJjSaDQ" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="qvFOZT4xVE6mBC151SsBVA" name="Lumen_duo_Duodenum_pls" description="Neighborhood between Lumen/Duodenum and Mucosa/Duodenum/Plasma" mode="Logical" containerType="Other" firstNeighbor="lZLwaVLayEa1f_nNQ00DVQ" secondNeighbor="qpsNmcf0yECPn6bPfvoWbA">
-              <Tags>
-                <Tag value="Lumen_duo_Duodenum_pls" />
-                <Tag value="Neighborhood: Duodenum / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="HvL4RFn_akWwOp4e1p-YtA" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="-93B5uQxiUaZjzyp5y_6_Q" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" formula="il5s5KHAwkObSxKDXaK80w" dim="Rate" quantityType="0" />
-                    <Transport id="IC4oY_ZXEEq363QbfIQQMQ" name="DrugAbsorption_para" description="Drug absorption paracellular" mode="Logical" containerType="Other" dimension="Dimensionless" formula="7nqcF4JuX02TZct9ETL_6g" sourceAmount="Cp9CcV7Ov06YVtSbGuudTw" targetAmount="NuXtwyVbBESYGyhe3qyqWQ" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="8NpDLeX1P0Ggjax84EkUug" name="Lumen_duo_Duodenum_cell" description="Neighborhood between Lumen/Duodenum and Mucosa/Duodenum/Intracellular" mode="Logical" containerType="Other" firstNeighbor="lZLwaVLayEa1f_nNQ00DVQ" secondNeighbor="yo07wiCfk0SB0-zR6Q-smQ">
-              <Tags>
-                <Tag value="Lumen_duo_Duodenum_cell" />
-                <Tag value="Neighborhood: Duodenum / Intracellular" />
-              </Tags>
-              <Children>
-                <Container id="cFcSg2AhaU-KV94BkzR5Sg" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="I_kkdw7RHUm2LExqC_a-uA" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="Aw8vq5KCWEOCAoMQrVN6FQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="vXtqeY1QuEm-dfloFVtgog" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="AAnDqAX9zUqoNDW37i4yBQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="Upgz1tIUzkGsoaD7B3PSHw" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="QWN9mrAel0-mdjkWIwyAtw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="YyW-hWkFb0yogquTMFi4tw" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="F6FIReabwUqeLEL5fA8UaA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="8fVMto0p_UefUGOG_uSncQ" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="Kf9Bxa2_b0Geq1rJPr-UGQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="PIMVXdO2LEmfNJArW6lzvQ" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="AkRbpFWVBEe9u5MbHZxalg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="xVuKOZswvkODR6XrDh8iMg" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="JUngAUX9gUCJH5Zj5zGPCw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="vZibFCdPBkazBcjf25t8ig" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="PpxkCCP9Z0qE-PahQOBMyA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="hS1XpI2qTEGj1ztZKIfCBQ" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="ordaQvtmhUGvMCSZnA5AeQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="4MaCQyf6W06Ri5O31pzl9A" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="q3UCyneZi0CZtpN2SylR9A" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="Fg2I0JrHq02wLYagwDZwLQ" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="xM7lqQL_aEy-cELqFKBf3w" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="Dy-4XYyuhkGcwgut9Rg3DA" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="PdH_puI8x0SM-tI3E7CmgQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="h68VP51zn0WqL66ALkp6pw" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="S_qjrFFhlUei9mGuxmLKJg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="2hSIEWlCXkmnqPj0E2Gafw" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="SzK_8omVIE-vZmY_eihelA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="cZR5dSuoFE6bsnlYANxm5Q" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="k8hWpEIpF0KjTAC5NbdvbA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="QdwGJcfI4kyx475s-byp0w" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="3uQ_8bks5kSiesc_SOfNwA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="4GoRAzs4AUGKLSqWiDmfQg" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="aJba9lRteUSyHr8r46GXyw" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="N1_T8urbrkS69frUaEqt4A" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="aMN4XH4f10CaDLbJlRvOYg" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="iZSkawKEckqlh8OhQhhcyw" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="WFbKuaD2_Uut_BXIFvFxpA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="EMggHI4XkUKW9aVEu9Nqtg" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" formula="JvZ8Tu8tHkOgK84I1hHYqw" dim="Rate" quantityType="0" />
-                    <Parameter id="4WH05bNSTkyEBA0mtzhh7Q" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="RJRIddynfU-kStoSCNdNxQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="Rv39qUDmqE-TrVFBk4_tDQ" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="S5rOyojRIUmpgOV6TPakRQ" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="z3aQNkXPRUyVGzn4y24POg" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" persistable="0" isFixedValue="0" formula="BveKpCpg9UmG-i-pECqAYA" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="vA2fsqtQrEyBiJOTeL-1Dg" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" persistable="0" isFixedValue="0" formula="gruA7u9_dEmTkoev_rv04g" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="uesx_Mzml0u7S7kiYToCkg" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="BxyyZmz-DESaOuk5gdzM7A" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="xRhlWyRbYEqkA3VSibayww" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="7uwBMa6hak63l8CME0302g" dim="Dimensionless" quantityType="0" />
-                    <Parameter id="Cm2w5QuEzki_CyU5BQJ2IQ" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" persistable="0" isFixedValue="0" formula="saXoPWZIxkGO4RXxXBKikw" dim="Dimensionless" quantityType="0" />
-                    <Transport id="-EJcA24u8UCxHxO--UCGYw" name="DrugAbsorption_trans" description="Drug absorption transcellular" mode="Logical" containerType="Other" dimension="Dimensionless" formula="Z1I3ZoP_BkalgosAlbBRXA" sourceAmount="Cp9CcV7Ov06YVtSbGuudTw" targetAmount="lzS0IgRFyUe26aoyeKkgTw" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="cjTSW8cYA0SAW79r83rM-g" name="Duodenum_pls_PortalVein_pls" description="Neighborhood between Duodenum/Plasma and PortalVein/Plasma" mode="Logical" containerType="Other" firstNeighbor="qpsNmcf0yECPn6bPfvoWbA" secondNeighbor="t3RJcRrWZk6Yk-_IRw-vvA">
-              <Tags>
-                <Tag value="Duodenum_pls_PortalVein_pls" />
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="AWGQQtREdkSWKYXwSvpWKw" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="Ryfs-an5cEG3qefsRdHbHw" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" persistable="0" isFixedValue="0" formula="RjPBCrbj2EeehCKsVJ0USw" dim="Rate" quantityType="0" />
-                    <Transport id="ZQVGv8LxBEiun086b0V9sg" name="MassTransferMucosaToPvePlasma" description="Mass transfer from Mucosa:Plasma To Portal Vein: Plasma" mode="Logical" containerType="Other" dimension="Dimensionless" formula="a-x58s1IKEmkgKlWYaQJDg" sourceAmount="NuXtwyVbBESYGyhe3qyqWQ" targetAmount="3epVIeHC_0m65IYsJjSaDQ" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="ojkFVZ-DsESfACX7ViSkWg" name="Duodenum_bc_PortalVein_bc" description="Neighborhood between Duodenum/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="G67GNfr5nUejQBYiVNI7Gw" secondNeighbor="UsK_koflU0aP-ubDRlslJQ">
-              <Tags>
-                <Tag value="Duodenum_bc_PortalVein_bc" />
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="eGpLuRA0gk2PUVDq7d1Ayg" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="IDR1NIblhEe-tGFawCfevA" name="Mass transfer rate (mucosa to portal vein blood cells)" description="Mass transfer rate (mucosa to portal vein blood cells)" persistable="0" isFixedValue="0" formula="JKJMTaiv80C0gCyGKmjD8g" dim="Rate" quantityType="0" />
-                    <Transport id="zxSmqQkPekOe1TUdnmcHRQ" name="MassTransferMucosaToPveBC" description="Mass transfer from Mucosa:Blood Cells To Portal Vein: Blood Cells" mode="Logical" containerType="Other" dimension="Dimensionless" formula="H5_5cUgNzEWrYqmKHHWmTQ" sourceAmount="I-wcOfVzhUubhukFSm8Z-A" targetAmount="F8UZepNEFEqiqDVPY4DDnA" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="KLm-viAPrEKX93hXMKWtLw" name="Lumen_colsigm_ColonSigmoid_pls" description="Neighborhood between Lumen/Colon Sigmoid and Mucosa/Colon Sigmoid/Plasma" mode="Logical" containerType="Other" firstNeighbor="t9buGgr6O02MMqVEqnLjgQ" secondNeighbor="OueVYReP4UKcfdpQe9-xDg">
-              <Tags>
-                <Tag value="Lumen_colsigm_ColonSigmoid_pls" />
-                <Tag value="Neighborhood: ColonSigmoid / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="SjXMYSr9a02K-bUpgRhWhQ" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="KPB80Zy4n0mp9vSvG6AikA" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" persistable="0" isFixedValue="0" formula="S3XPbUNx5EiJlUh6BegeVA" dim="Rate" quantityType="0" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="i8xlzRGsQEWhMKFNjhHzIQ" name="ColonSigmoid_bc_PortalVein_bc" description="Neighborhood between Colon Sigmoid/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="VFAajW768UeoKlpXQfnVNA" secondNeighbor="UsK_koflU0aP-ubDRlslJQ">
-              <Tags>
-                <Tag value="ColonSigmoid_bc_PortalVein_bc" />
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="Xue-9QhGOUetR3Eke1T5Xw" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Parameter id="jRWiqdzc9EG3XCVC_s8ZyA" name="Mass transfer rate (mucosa to portal vein blood cells)" description="Mass transfer rate (mucosa to portal vein blood cells)" persistable="0" isFixedValue="0" formula="VWfViKsyjkCu7dF1WXOItA" dim="Rate" quantityType="0" />
-                    <Transport id="oaxezuPU-U-5UOvQdzwEkA" name="MassTransferMucosaToPveBC" description="Mass transfer from Mucosa:Blood Cells To Portal Vein: Blood Cells" mode="Logical" containerType="Other" dimension="Dimensionless" formula="H5re4n44pE6UlO2Ajfd05w" sourceAmount="bftHsV58IEij5P2Nw6mjNA" targetAmount="F8UZepNEFEqiqDVPY4DDnA" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="DMar9WbjjEKXahbngYZ6-A" name="ArterialBlood_bc_Brain_bc" description="Neighborhood between Arterial Blood/Blood Cells and Brain/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="yHKVfLHCj02vJfFqJ_50sQ" secondNeighbor="xcX6xUb0qUCOHyUT7SoyuQ">
-              <Tags>
-                <Tag value="ArterialBlood_bc_Brain_bc" />
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="4_3_s0EcrkitsAUvGTxLVw" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Transport id="LXdlGrq5f0O9ipp2dPc8Iw" name="MassTransferBloodPool2OrgRBC" description="Mass transfer from ArterialBlood: BloodCells to organ: Blood Cells" mode="Logical" containerType="Other" dimension="Dimensionless" formula="Jj7BmOGAVEOARKASlNz79Q" sourceAmount="KoF_gPV3a0C8KDxsooKTTQ" targetAmount="M6OtacKy4UGZaIp9ew6wbw" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="56AKpFgVvUaGEaHoOa5JIQ" name="ArterialBlood_bc_Bone_bc" description="Neighborhood between Arterial Blood/Blood Cells and Bone/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="yHKVfLHCj02vJfFqJ_50sQ" secondNeighbor="9PgVSRUEFky2ekQwkIaHHw">
-              <Tags>
-                <Tag value="ArterialBlood_bc_Bone_bc" />
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="_I_Tg6qanECKqmzd-OPUTg" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Transport id="43mhMXUGHEWRWFy39HMvtA" name="MassTransferBloodPool2OrgRBC" description="Mass transfer from ArterialBlood: BloodCells to organ: Blood Cells" mode="Logical" containerType="Other" dimension="Dimensionless" formula="NwIdWzuvCEKMiiQzLEbzyQ" sourceAmount="KoF_gPV3a0C8KDxsooKTTQ" targetAmount="Fn6IF-t_c06tyZDdsv9GJA" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="B-lTjbOO3kmGKjim0xCvDA" name="ArterialBlood_bc_Fat_bc" description="Neighborhood between Arterial Blood/Blood Cells and Fat/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="yHKVfLHCj02vJfFqJ_50sQ" secondNeighbor="UCI13t7Y1UeZyAqMB-vPQA">
-              <Tags>
-                <Tag value="ArterialBlood_bc_Fat_bc" />
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="UrutryN3qkOjT29dj5-zTA" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Transport id="Aoekg2tgb0CTCgmDnyJiOA" name="MassTransferBloodPool2OrgRBC" description="Mass transfer from ArterialBlood: BloodCells to organ: Blood Cells" mode="Logical" containerType="Other" dimension="Dimensionless" formula="YDLIOGMy8UKMHIxTcqVyWA" sourceAmount="KoF_gPV3a0C8KDxsooKTTQ" targetAmount="6Fgkh6wtHEKhlsf-k4BBww" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="YLa12rfE1ku88Ue_ZIs99A" name="ArterialBlood_bc_Gonads_bc" description="Neighborhood between Arterial Blood/Blood Cells and Gonads/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="yHKVfLHCj02vJfFqJ_50sQ" secondNeighbor="OgNkWaheck6JK2s9i6-9DQ">
-              <Tags>
-                <Tag value="ArterialBlood_bc_Gonads_bc" />
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="_3oLv_aQRE-9D-CYkEb5Sg" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Transport id="MYFBlpjoWEa8Y5563af_XQ" name="MassTransferBloodPool2OrgRBC" description="Mass transfer from ArterialBlood: BloodCells to organ: Blood Cells" mode="Logical" containerType="Other" dimension="Dimensionless" formula="xWNwq_DOlkqK_wehPF4Qsg" sourceAmount="KoF_gPV3a0C8KDxsooKTTQ" targetAmount="ePM3dZXuUEO7zYoYxZnSKw" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="Rrcc0OoS_0mCRVAg-gph9w" name="ArterialBlood_bc_Heart_bc" description="Neighborhood between Arterial Blood/Blood Cells and Heart/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="yHKVfLHCj02vJfFqJ_50sQ" secondNeighbor="p5ZOEMF5SkKVwHS_PuCniQ">
-              <Tags>
-                <Tag value="ArterialBlood_bc_Heart_bc" />
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-                <Container id="oNMRXyLCOE61mvHhkWa3nQ" name="Drug" mode="Logical" containerType="Other">
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-                    <Transport id="VPGGAAuOUkmbZOw_t_1T7A" name="MassTransferBloodPool2OrgPl" description="Mass transfer from Arterial Blood: Plasma to organ: Plasma" mode="Logical" containerType="Other" dimension="Dimensionless" formula="mZ193FcEQkWqaJemK5mQ-g" sourceAmount="-KHwz6KsaUKMJrU3wcwlsw" targetAmount="smW_5fUV7Uil14J2vlu7cA" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="W9iLlkWhv02nZpelvcBZeg" name="ArterialBlood_bc_Pancreas_bc" description="Neighborhood between Arterial Blood/Blood Cells and Pancreas/Blood Cells" mode="Logical" containerType="Other" firstNeighbor="yHKVfLHCj02vJfFqJ_50sQ" secondNeighbor="bC2pK9qHBUKn8mZbyhrQUA">
-              <Tags>
-                <Tag value="ArterialBlood_bc_Pancreas_bc" />
-                <Tag value="Neighborhood: BloodCells / BloodCells" />
-              </Tags>
-              <Children>
-                <Container id="qfYuN6csJkC2iOF0ld-MJA" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Transport id="UuIugPdYzUCTMce32OCbTg" name="MassTransferBloodPool2OrgRBC" description="Mass transfer from ArterialBlood: BloodCells to organ: Blood Cells" mode="Logical" containerType="Other" dimension="Dimensionless" formula="FObeNZ77y0CUuAFlWeGyeg" sourceAmount="KoF_gPV3a0C8KDxsooKTTQ" targetAmount="9968Lq-A-0-c-nNV7nhWCA" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="fdbeimF-0U2HmMGMzEGt5A" name="ArterialBlood_pls_Fat_pls" description="Neighborhood between Arterial Blood/Plasma and Fat/Plasma" mode="Logical" containerType="Other" firstNeighbor="p_fPz7AdjkmBeY1cPby9Qw" secondNeighbor="0jH8wQWByEGQirnpU3MU9w">
-              <Tags>
-                <Tag value="ArterialBlood_pls_Fat_pls" />
-                <Tag value="Neighborhood: Plasma / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="bUqn-nvarUui653esZ5Ppw" name="Drug" mode="Logical" containerType="Other">
-                  <Children>
-                    <Transport id="h2xjwroXRU6zQSxGRNhy9w" name="MassTransferBloodPool2OrgPl" description="Mass transfer from Arterial Blood: Plasma to organ: Plasma" mode="Logical" containerType="Other" dimension="Dimensionless" formula="Eb0sXdpqaEi5_ZDI_fCH1g" sourceAmount="-KHwz6KsaUKMJrU3wcwlsw" targetAmount="I1lH2_D7D0yUrk6B1gdFsg" />
-                  </Children>
-                </Container>
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="-Ldg7_2LzUSLjrSiy8UwLg" name="LowerJejunum_cell__VenousBlood_pls" description="Neighborhood between SmallIntestine/Mucosa/LowerJejunum/Interstitial and Venous Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="5PomAWE2VkC-slCzt2mnVw" secondNeighbor="R5jgBt3okEeUHClw7hT2EA">
-              <Tags>
-                <Tag value="LowerJejunum_cell__VenousBlood_pls" />
-                <Tag value="Neighborhood: Interstitial / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="0ASM_TG-5UaKomrAJLFtaw" name="Drug" mode="Logical" containerType="Other" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="nilN3UWxY0K1cO9J0WoSIA" name="UpperJejunum_cell__VenousBlood_pls" description="Neighborhood between SmallIntestine/Mucosa/UpperJejunum/Interstitial and Venous Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="THYGK8yE7UOOTBWK-3FzrA" secondNeighbor="R5jgBt3okEeUHClw7hT2EA">
-              <Tags>
-                <Tag value="UpperJejunum_cell__VenousBlood_pls" />
-                <Tag value="Neighborhood: Interstitial / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="PY5n-PW4skiWKizxLjQh4w" name="Drug" mode="Logical" containerType="Other" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="N8A_VpqNcUygRnHVEyl9nA" name="Duodenum_cell__VenousBlood_pls" description="Neighborhood between SmallIntestine/Mucosa/Duodenum/Interstitial and Venous Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="ywuD3Bwyok28OM2s_VCT0w" secondNeighbor="R5jgBt3okEeUHClw7hT2EA">
-              <Tags>
-                <Tag value="Duodenum_cell__VenousBlood_pls" />
-                <Tag value="Neighborhood: Interstitial / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="2qLgWbPQKUW0j6NKkXROOg" name="Drug" mode="Logical" containerType="Other" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="-T1klb4l1EmTwSH8Wv9l3w" name="LowerIleum_cell__VenousBlood_pls" description="Neighborhood between SmallIntestine/Mucosa/LowerIleum/Interstitial and Venous Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="40GEupwcu0KOCUrSxYbAIg" secondNeighbor="R5jgBt3okEeUHClw7hT2EA">
-              <Tags>
-                <Tag value="LowerIleum_cell__VenousBlood_pls" />
-                <Tag value="Neighborhood: Interstitial / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="SnFnI__2m0GfV_6U1e-4Cw" name="Drug" mode="Logical" containerType="Other" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="EsrZgLx58Ei6c_w72l6g5g" name="Caecum_cell__VenousBlood_pls" description="Neighborhood between LargeIntestine/Mucosa/Cecum/Interstitial and Venous Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="XQ9QHp4bX0ieSHXh2FVHVw" secondNeighbor="R5jgBt3okEeUHClw7hT2EA">
-              <Tags>
-                <Tag value="Caecum_cell__VenousBlood_pls" />
-                <Tag value="Neighborhood: Interstitial / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="JHQKdRh830iuuVYWqmK2_g" name="Drug" mode="Logical" containerType="Other" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="IcrOq56KjUiCVCcLQJg4TA" name="UpperIleum_cell__VenousBlood_pls" description="Neighborhood between SmallIntestine/Mucosa/UpperIleum/Interstitial and Venous Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="h_HrULaBNU63NUv9o6Picg" secondNeighbor="R5jgBt3okEeUHClw7hT2EA">
-              <Tags>
-                <Tag value="UpperIleum_cell__VenousBlood_pls" />
-                <Tag value="Neighborhood: Interstitial / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="d6jJOYKEmkmdckhbcmVQXw" name="Drug" mode="Logical" containerType="Other" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="xxrjaTyWtE-6PJVTFdRhrg" name="Rectum_cell__VenousBlood_pls" description="Neighborhood between LargeIntestine/Mucosa/Rectum/Interstitial and Venous Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="8Dqh8-N8EkePTw3n4M3mxA" secondNeighbor="R5jgBt3okEeUHClw7hT2EA">
-              <Tags>
-                <Tag value="Rectum_cell__VenousBlood_pls" />
-                <Tag value="Neighborhood: Interstitial / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="fRuJW-7jp0OK6GEdA1C6wg" name="Drug" mode="Logical" containerType="Other" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="AjCbN8o0g0OkSt629dOZZw" name="ColonSigmoid_cell__VenousBlood_pls" description="Neighborhood between LargeIntestine/Mucosa/ColonSigmoid/Interstitial and Venous Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="tp-AgqcxjUix4Bk1CBNHOA" secondNeighbor="R5jgBt3okEeUHClw7hT2EA">
-              <Tags>
-                <Tag value="ColonSigmoid_cell__VenousBlood_pls" />
-                <Tag value="Neighborhood: Interstitial / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="FKzwOpwhZkqurWTooscuaQ" name="Drug" mode="Logical" containerType="Other" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="5IcJHYTz2UC5VOvdLrJoMA" name="ColonDescendens_cell__VenousBlood_pls" description="Neighborhood between LargeIntestine/Mucosa/ColonDescendens/Interstitial and Venous Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="f7z66YOv_0Kv2m70sTfn_g" secondNeighbor="R5jgBt3okEeUHClw7hT2EA">
-              <Tags>
-                <Tag value="ColonDescendens_cell__VenousBlood_pls" />
-                <Tag value="Neighborhood: Interstitial / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="RxN7kv_BuU2qHXkweKTwzw" name="Drug" mode="Logical" containerType="Other" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="i_OLnuY1Z0-VEjslRI70DA" name="ColonTransversum_cell__VenousBlood_pls" description="Neighborhood between LargeIntestine/Mucosa/ColonTransversum/Interstitial and Venous Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="jMOo8Y0r2kymd4Qciv0Vvw" secondNeighbor="R5jgBt3okEeUHClw7hT2EA">
-              <Tags>
-                <Tag value="ColonTransversum_cell__VenousBlood_pls" />
-                <Tag value="Neighborhood: Interstitial / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="fvRqrBmq0Ei73PadADCujw" name="Drug" mode="Logical" containerType="Other" />
-              </Children>
-            </Neighborhood>
-            <Neighborhood id="JrVJOCNt8E6c8-brlMG0xQ" name="ColonAscendens_cell__VenousBlood_pls" description="Neighborhood between LargeIntestine/Mucosa/ColonAscendens/Interstitial and Venous Blood/Plasma" mode="Logical" containerType="Other" firstNeighbor="3wSRCym4P0qw0qkBrNzwjA" secondNeighbor="R5jgBt3okEeUHClw7hT2EA">
-              <Tags>
-                <Tag value="ColonAscendens_cell__VenousBlood_pls" />
-                <Tag value="Neighborhood: Interstitial / Plasma" />
-              </Tags>
-              <Children>
-                <Container id="GCJBE9TlFUm7B33isbhUjQ" name="Drug" mode="Logical" containerType="Other" />
-              </Children>
-            </Neighborhood>
-          </Children>
-        </Container>
-        <Container id="a3xJnS6bPEa0EL4prcikNg" name="Drug" icon="Drug" mode="Logical" containerType="Molecule">
-          <Children>
-            <Parameter id="EPxgsovrYEez6pbEfK3W7g" name="Intestinal permeability (paracellular)" description="Intestinal permeability via paracellular route" persistable="0" isFixedValue="0" formula="HtNrN9E1_0e9-VOXC29mLg" dim="Velocity" quantityType="0" buildMode="Global" />
-            <Parameter id="HIHTUifzmEKteaPSqwNBLw" name="P_bc_pls_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="D-g9Rz5Xe0qDNbAa3KOp5A" dim="Dimensionless" quantityType="0" buildMode="Global" />
-            <Parameter id="Ep6xLDMr4kqaM0BnBfZlqA" name="P (blood cells-&gt;plasma)" description="Permeability from blood cells to plasma" persistable="0" isFixedValue="0" formula="tv7ASrjReUWDf7oZhf6i5Q" dim="Velocity" quantityType="0" buildMode="Global" />
-            <Parameter id="-xaiMLVMNkmB9uJH_WdYxQ" name="Partition coefficient (blood/plasma)" description="Partition coefficient between blood and plasma" persistable="0" isFixedValue="0" formula="G8r0FVmmDUq7a3YQ9Y41pw" dim="Dimensionless" quantityType="0" buildMode="Global" />
-            <Parameter id="B2vr0FXyJU6tGmZccMO34w" name="Partition coefficient (blood cells/plasma)" description="Partition coefficient between blood cells and plasma" persistable="0" isFixedValue="0" formula="i83qoeOmyUeLVz0sXdZKdA" dim="Dimensionless" quantityType="0" buildMode="Global" />
-            <Parameter id="zkLXp0ZSIEiH_LaOaef9Zg" name="P_pls_bc_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" persistable="0" isFixedValue="0" formula="OZ4R38S8O0G1MUP0ZteriQ" dim="Dimensionless" quantityType="0" buildMode="Global" />
-            <Parameter id="cfOtk4d83UqKkFR5r8Ogcg" name="P (plasma-&gt;blood cells)" description="Permeability from plasma to blood cells" persistable="0" isFixedValue="0" formula="pCBNk-YXzEmu6TNiVXAeYQ" dim="Velocity" quantityType="0" buildMode="Global" />
-            <Parameter id="FsYhH8253UOT2cxs7-BJ7w" name="Intestinal permeability (transcellular)" description="Intestinal permeability via transcellular route" persistable="0" isFixedValue="0" formula="NVuQ0dY20EOCL9DqG_3XUA" dim="Velocity" quantityType="0" buildMode="Global" />
-            <Parameter id="cRl-X-Ipjk2ufsBCzByDFw" name="pKa_Acid_2" description="Largest acid pKa" persistable="0" isFixedValue="0" formula="Sbnk4Q2pMEGgG5FGp4ejOw" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="PlbZbQo8-kGhpHbBnuVTig" name="pKa_pH_WS_sol_K1" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" formula="IUsyf0braEKr7LkaXT_FrQ" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="ip3H8Tiv_kW_FxoTEWPMrg" name="Is triprotic base" description="Is triprotic base" persistable="0" isFixedValue="0" formula="QUAH2vcilUaS2YUIkvoo2w" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="f2Bf39nRNUGvYPD1S0XFWw" name="Molecular weight" description="Molecular weight" persistable="0" isFixedValue="0" formula="xbxF-JStfUugxIWDQwgD_g" dim="MolecularWeight" quantityType="0" buildMode="Property" />
-            <Parameter id="7DZVKuALe0KfkaiVh2Mj0g" name="pKa value 0" description="pKa value" persistable="0" isFixedValue="0" formula="HQqsYcDSpEa9eQDZsf1fXA" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="bFAvEGNSRkSmpcBCdCF3_Q" name="pKa value 1" description="pKa value" persistable="0" isFixedValue="0" formula="JZRmuhWftEW200pwi1H_4w" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="g1kz8UUuFk-HZM3yFBvAAg" name="pKa value 2" description="pKa value" persistable="0" isFixedValue="0" formula="b1X-59v6AEixyGrs0BKlSg" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="9Wni5se_AkuyqxHwwSoaUg" name="Is strong base" description="Supporting parameter for partition coeffs in RR-Modell (at least one basic pKa&gt;=7)" persistable="0" isFixedValue="0" formula="I7sD611OEUKOjVf0X26jvg" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="lmlv_Bq_QEKMF7WElPyqkw" name="pKa_Acid_1" description="Middle acid pKa" persistable="0" isFixedValue="0" formula="F7AT737nJkq7TOYzkpr6AA" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="057nXsmNb06ALxLQOPmXQQ" name="Is small molecule" description="Treat compound as small molecule or not (if not, both organ specific and intestinal permeability will be set to zero)" persistable="0" isFixedValue="0" formula="4uEekK3bEUGk2032uG95aQ" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="aOo86pTyOESYEi_ULMMp3A" name="pKa_Acids_Count" description="Number of acidic groups in compound" persistable="0" isFixedValue="0" formula="9o-qjnFMcEO-kj0fbVIzDQ" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="NKcgrcpzEkinCAg3SAS8Gg" name="pKa_Base_0" description="Smallest base pKa" persistable="0" isFixedValue="0" formula="yKOGwHZyuE6JN1laXWi3ug" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="hwyyvIQ-kk2F0dujfnNULA" name="pKa_Base_1" description="Middle base pKa" persistable="0" isFixedValue="0" formula="qX2i6gDfdEWt02Xov_fB_A" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="dVpaB99PuU2GsVqjYvTVrA" name="pKa_Base_2" description="Largest base pKa" persistable="0" isFixedValue="0" formula="ZsXkbxOhsUG5_TLFbrpJXw" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="vPtN8GIr3kiBSEccXeaOhg" name="pKa_Bases_Count" description="Number of basic groups in compound" persistable="0" isFixedValue="0" formula="XNV_lbiR5kCzx-KPjKVKQA" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="lB8OR6g2ukegahVAV8W9aw" name="pKa_OneAcid_0" description="Smallest acid pKa for compound with 1 acid group" persistable="0" isFixedValue="0" formula="I3oiWlfH9EWJhUe_FoJypw" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="ThcPnppihUqiQZ59OMRSTA" name="pKa_OneBase_0" description="Smallest base pKa for compound with 1 base group" persistable="0" isFixedValue="0" formula="4z9zdsQQh0CtOmMQKH4bBg" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="McSzEYmlLESPwY5SSswQRA" name="pKa_pH_WS_sol_F1" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" formula="hO1aIJvroUGFwJxZYwXnCA" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="EEeJDoF_aEOkU5GMnpV4vA" name="pKa_pH_WS_sol_F2" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" formula="v8GiWmv5AEmwXQPNdC__xQ" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="VT6D-y2gNkWhWd_syTHR9g" name="pKa_Acid_0" description="Smallest acid pKa" persistable="0" isFixedValue="0" formula="jTEVRUtcK0eZ_EKOho1yTA" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="ebeeJl5qBkKK72n0alNqkg" name="I" description="Number of iodine atoms in molecule" persistable="0" isFixedValue="0" formula="1CYgsrqtCEuf30fiyG_ZvQ" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="mO2js0BnhEqQJwwXTGjTjg" name="Compound type 1" description="Compound type (-1: acid, +1: base, 0: neutral)" persistable="0" isFixedValue="0" formula="8sDOBjy5-kCFlhDqdCXdvA" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="uwZACI2D80-B78syW0EIQQ" name="Compound type 2" description="Compound type (-1: acid, +1: base, 0: neutral)" persistable="0" isFixedValue="0" formula="8msV_lcYtEOfKNUmF6hqqA" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="dOwqm-l_dkuYa8MRuQI77A" name="CT_ACID" description="Constant for compound type acid" persistable="0" isFixedValue="0" formula="NOFyeJi3PkCEI56vtR-Nng" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="3kpQBZ32vkCZ170I8duA-A" name="CT_BASE" description="Constant for compound type base" persistable="0" isFixedValue="0" formula="_AH6vauHDkK8MrWyH4s1Ww" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="hCW_KQPZoEuO9cy1eB1fHQ" name="CT_NEUTRAL" description="Constant for compound type neutral" persistable="0" isFixedValue="0" formula="EvaPHA-lMUyAY8jHJow3mA" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="jrsmUzXaj0KPJDGBwklOXA" name="Effective molecular weight" description="Effective molecular weight" persistable="0" isFixedValue="0" formula="_gdeTZzZNE2hkusderSY2A" dim="MolecularWeight" quantityType="0" buildMode="Property" />
-            <Parameter id="Y4yqIzGwyEu-mA5kl2w5vQ" name="F" description="Number of fluorine atoms in molecule" persistable="0" isFixedValue="0" formula="ImjHnUl8GE-n2pGkYPgxuw" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="dnT-dfxbG0ia8l2CguiFrA" name="Is triprotic acid" description="Is triprotic acid" persistable="0" isFixedValue="0" formula="taHuCeqmk0GU2IODCakDiQ" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="OfEXHyOL-UO6Y2SGKKyY9w" name="Has halogens" description="Supporting parameter for compound" persistable="0" isFixedValue="0" formula="wvjng6khI02p3G5uOoLOdg" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="42EADne9Y0Ca6y0-vJDSOA" name="pKa_pH_WS_sol_K2" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" formula="0bOW5_Bv2Uq_VHADmLS4Fg" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="-Kdehue30kWgCsiOTIPUOg" name="Is diprotic acid" description="Is diprotic acid" persistable="0" isFixedValue="0" formula="HVP2j-Ho4UOmjbA4SnnTkw" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="Gev4OzhwOECJytMJ7CWtbA" name="Is diprotic base" description="Is diprotic base" persistable="0" isFixedValue="0" formula="0YTKrSdpm0Cux2Yb2MC28g" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="QPYxxEnVlEa9dqIISZPE8g" name="Is diprotic base monoprotic acid" description="Is diprotic base monoprotic acid" persistable="0" isFixedValue="0" formula="rfnli4GYxkWNJo9QMf91lg" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="2oEsRX0jtkOv6n4zXsEaQw" name="Is floating in lumen" description="Is floating in lumen" persistable="0" isFixedValue="0" formula="9vp7opFXnkySKRWqLXH8-g" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="6ZzLSgukPkWftIY4oD3ETQ" name="Is monoprotic acid" description="Is monoprotic acid" persistable="0" isFixedValue="0" formula="Q2fNORRRoEKh11w5napLkw" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="SW_wAzMNFUGo4CWAdD75iA" name="Is monoprotic base" description="Is monoprotic base" persistable="0" isFixedValue="0" formula="8vK7h4P7h0qh5pTBtsQ1WQ" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="OX5C9WXkdEGSNjksh7KP1w" name="Is monoprotic base diprotic acid" description="Is monoprotic base diprotic acid" persistable="0" isFixedValue="0" formula="lfT6erIuhEuxat5bsF39-A" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="Ni82EIA2BEqeSPMKb6MSyw" name="Is monoprotic base monoprotic acid" description="Is monoprotic base monoprotic acid" persistable="0" isFixedValue="0" formula="4Nqs2BLjG0CcpikW87abDA" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="ZVL-NYOb1k-xzaOMrIjCUA" name="Is neutral" description="Supporting parameter for partition coeffs in RR-Modell" persistable="0" isFixedValue="0" formula="yO1a3sxl_Uy-piXJ6MLWFQ" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="o4rGtS8xrkmCyOP1c9tMPQ" name="pKa_pH_WS_sol_F3" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" formula="AogKch0IZkiIDwUv8nISfw" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="ok-pPRE5NkWU5b_KDuWgvQ" name="pKa_TwoAcids_1" description="Middle acid pKa for compound with 2 acid groups" persistable="0" isFixedValue="0" formula="y3XAaPzNrEiH8y8gCMMMEA" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="gH-I2EVGSECIUo2Qf8_HOg" name="pKa_pH_WS_sol_K3" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" formula="WIaqbOlyNUyKPsp41PeUjA" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="MrSDiMqyuEOYdeSLmpdN7A" name="pKa_pH_WS_sol_K4" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" formula="AAqIBNaST0yWM12Vc93W4g" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="htnDkmPxM0K3qZYxmfI8Cw" name="pKa_pH_WS_sol_K5" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" formula="ERyWKVpZx0Cs1inyglta_A" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="Z4VTogK9TUyG9r4LRceBAA" name="pKa_pH_WS_sol_K6" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" formula="RBMyAucUfki85GoK2w8tzQ" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="NwSFH579lEGyFBxJXkd9KQ" name="pKa_pH_WS_sol_K7" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" formula="4kCZiUPpJUmN5TKPFzHBag" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="0NzBAkaihU26fYBuXS6m_w" name="pKa_pH_WS_sol_K8" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" formula="wWyvtiGq9UygnZ3syUlcIg" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="FOpAUNqPAkyyFNs_DOPkXg" name="pKa_ThreeAcids_0" description="Smallest acid pKa for compound with 3 acid groups" persistable="0" isFixedValue="0" formula="0dTm_ONE1E-_xeX-rZXX3w" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="Bwr-IR-8d02xXHdKZgXUIQ" name="pKa_ThreeAcids_1" description="Middle acid pKa for compound with 3 acid groups" persistable="0" isFixedValue="0" formula="lteSI2UfD0e-7Yz7bP85kQ" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="NGO2OEAaB0Sw_waYXi3aOw" name="pKa_ThreeBases_0" description="Smallest base pKa for compound with 3 base groups" persistable="0" isFixedValue="0" formula="45HlZ2Y860WlJ2jv7Jd-1g" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="7i0uut4unUCVgcb9Uje38g" name="pKa_TwoAcids_0" description="Smallest acid pKa for compound with 2 acid groups" persistable="0" isFixedValue="0" formula="wjpBIMzS90-stcW-3OoAeQ" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="EAmbJRRTj0eWGsuT4H8Suw" name="pKa_TwoBases_0" description="Smallest base pKa for compound with 2 base groups" persistable="0" isFixedValue="0" formula="PC25kBbN3kG0_AVVajJHMQ" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="Ze3qPFPPdkiOZGwTsU091g" name="pKa_TwoBases_1" description="Middle base pKa for compound with 2 base groups" persistable="0" isFixedValue="0" formula="_W32QW30jUGR-IEpVsKOyg" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="hIfNfKn_aUCVcqA4EIca-A" name="Solubility gain per charge" description="Supporting parameter for calculation of pKa- and pH- dependent values of intestinal solubilty" persistable="0" isFixedValue="0" formula="_LlMP-GP0kKR3Mz4hJIefA" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="L7sYdu3Lw0OM2aI5r2HItw" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" persistable="0" isFixedValue="0" formula="x3heyoTGaEm5cpbYuszt0w" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="wmlU0SVKDUG1ofJseYVjLw" name="Total oral drug mass" description="Total oral drug mass" persistable="0" isFixedValue="0" formula="T7Yfjty1fkqV5J8Ji6zKBg" dim="Amount" quantityType="0" buildMode="Property" />
-            <Parameter id="-5XL7ouRQUSemBuWngYbbA" name="pKa_ThreeBases_1" description="Middle base pKa for compound with 3 base groups" persistable="0" isFixedValue="0" formula="vHLCNrQndEaYStB1-XRs6w" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="E93iS_bJVkW284OgxynmTg" name="Cl" description="Number of chlorine atoms in molecule" persistable="0" isFixedValue="0" formula="wZuqalKL2U-wDTdAtRCNnA" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="SNYF0cTuOkOA7vEM3U4RRg" name="Br" description="Number of bromine atoms in molecule" persistable="0" isFixedValue="0" formula="PrM1VUpG6E2whl_wCJ4ong" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="cpdS7tTY0Uuxvo3kao0WvQ" name="Compound type 0" description="Compound type (-1: acid, +1: base, 0: neutral)" persistable="0" isFixedValue="0" formula="pgnC_VjI2EuBFgw0zzLCmA" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="WwzPZwEvGkmJ6_WpVXOnVw" name="base_For_KaPL_Factor" description="Supporting parameter for calculation of pKa- and pH- dependent values of KaPL" persistable="0" isFixedValue="0" formula="YvGB7a9EW0KgShClzFoWPg" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="tivLKERgDEySQ-75-Spzqw" name="base_For_logD_Factor" description="Supporting parameter for calculation of pKa- and pH- dependent logD" persistable="0" isFixedValue="0" formula="Ha1AmjI95UGGY8r5t2e2-g" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="GBwDS8YKnEqTOB1eMqmaoA" name="base_For_P_cell_Factor" description="Supporting parameter for calculation of pKa- and pH- dependent permeability to/from cells" persistable="0" isFixedValue="0" formula="xbfyIErz2E-hxmrEV01eRA" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="pg7jTFkjaEOwVrOdy3tXQw" name="base_For_Pint_Factor" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="6qKwJD9lrk67tOeBFze4FA" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="AECYac-sJUemApdHir3R1A" name="Lipophilicity" description="Model dependent lipophilicity measure: LogMA / LogP / ..." persistable="0" isFixedValue="0" formula="QTGTyJOpzkSyyKQ2x4x4Lg" dim="Lipophilicity" quantityType="0" buildMode="Property" />
-            <Parameter id="pHLLs8yiqkOSCrJhCJB8hg" name="Fraction unbound (plasma)" description="Fraction unbound in plasma" persistable="0" isFixedValue="0" formula="ML95D99scEeWF-gr1I6i4w" dim="Fraction" quantityType="0" buildMode="Property" />
-            <Parameter id="9Yj5Xjlh7kiyQTzyeKr1PQ" name="Solubility at reference pH" description="Solubility at reference pH" persistable="0" isFixedValue="0" formula="cQrv4UI5OkODvNYHTvRW8g" dim="Concentration" quantityType="0" buildMode="Property" />
-            <Parameter id="aWNjQuSEPUy2cYX5845KaQ" name="Reference pH" description="Reference pH" persistable="0" isFixedValue="0" formula="Sx0IssvosUCBmTnhom9NpA" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="ugxan2JeZE6j6_dqdBBd2A" name="Permeability" description="Permeability" persistable="0" isFixedValue="0" formula="Zx90sdkJikGNbUnct14wwg" dim="Velocity" quantityType="0" buildMode="Property" />
-            <Parameter id="asOZIwRzzUyo_TfPS0wH1g" name="Specific intestinal permeability (transcellular)" description="Specific intestinal permeability (transcellular)" persistable="0" isFixedValue="0" formula="KKdfVw7fPUKjSeGnkCAx6Q" dim="Velocity" quantityType="0" buildMode="Property" />
-            <Parameter id="9M0P4vsVL0yK4NoqOt02GQ" name="Partition coefficient (water/protein)" description="Partition coefficient water to protein" persistable="0" isFixedValue="0" formula="FOySywJR2ke5EkXXhNUriQ" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="zxtZ2D7Np0aaUYTPjmBEAg" name="Treat precipitated drug as" description="Treat precipitated drug as either soluble or insoluble" persistable="0" isFixedValue="0" formula="BFzljU8wIky_aeZ9gJWCrA" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="fLlKrIzDwUqfeN4YMWYPjg" name="Aqueous diffusion coefficient" description="Aqueous diffusion coefficient&#xA;of the drug" persistable="0" isFixedValue="0" formula="LDumG6rqjEexHToYOfIjrQ" dim="DiffusionCoefficient" quantityType="0" buildMode="Property" />
-            <Parameter id="FFfZ2AosLUiIj5puY3yOfA" name="Density (drug)" description="Density of drug material" persistable="0" isFixedValue="0" formula="BrqTa8Sh9Ei_5zhO_OgTow" dim="Density" quantityType="0" buildMode="Property" />
-            <Parameter id="yFzgZuHAtUi0qyIbohP71g" name="Immediately dissolve particles smaller than" description="Threshold for the particle radius of immediate dissolution" persistable="0" isFixedValue="0" formula="420WbtQm90O2OKmXyeNOTQ" dim="Nanolength" quantityType="0" buildMode="Property" />
-            <Parameter id="Q09At_BNm0q_GcoTI0EBQQ" name="Radius (solute)" description="Solute radius" persistable="0" isFixedValue="0" formula="433yTHoK0UOv1dgmhHKaXQ" dim="Nanolength" quantityType="0" buildMode="Property" />
-            <Parameter id="ITX_M7HRPUSBQlQ5Ozv_Dw" name="Kd (FcRn)" description="Dissociation constant for binding of drug to FcRn" persistable="0" isFixedValue="0" formula="kla8KnPiEkGTNoT1q1oM2Q" dim="MolarConcentration" quantityType="0" buildMode="Property" />
-            <Parameter id="1QcKhpraLku-jEoUCnfLuw" name="Use pH- and pKa-dependent penalty factor for charged molecule fraction" description="Penalty factor for charged molecule fraction is used for &quot;Intestinal permeability (transcellular)&quot; only" persistable="0" isFixedValue="0" formula="3gvwejaIskOx9c_D3W1ZzQ" dim="Dimensionless" quantityType="0" buildMode="Property" />
-          </Children>
-        </Container>
-        <Container id="H6xFjkNYmUK1UDq6XtsAJg" name="Cyp" icon="Enzyme" mode="Logical" containerType="Molecule">
-          <Children>
-            <Parameter id="lcKA8te0G0SL3Zp5fyJq-A" name="Relative expression in plasma (normalized)" description="Relative expression norm in plasma" persistable="0" isFixedValue="0" formula="9fThSGWtNk2F8InDrBWHhA" dim="Fraction" quantityType="0" buildMode="Global" />
-            <Parameter id="iVTsbtJ7qUqUF_sqtNKkGg" name="Relative expression in vascular endothelium" description="Relative expression in vasc. Endothelium" persistable="0" isFixedValue="0" formula="7GOPAPJTIEqlJEWrJgYb7g" dim="Fraction" quantityType="0" buildMode="Global" />
-            <Parameter id="7CfKEyy5Ckm3fYGTMzW0Nw" name="Relative expression in plasma" description="Relative expression in plasma" persistable="0" isFixedValue="0" formula="pVHYX-RBvkCHNKYvM_6Erg" dim="Fraction" quantityType="0" buildMode="Global" />
-            <Parameter id="rKGy3XQY4kSXVbbPw_m0aw" name="Relative expression in blood cells" description="Relative expression in blood cells" persistable="0" isFixedValue="0" formula="uVfA_hnbNUumZ8oNVzdxbg" dim="Fraction" quantityType="0" buildMode="Global" />
-            <Parameter id="7wy5tiY49EC81Bh_yUGkSQ" name="Rel. exp. variability factor" description="Variability factor for relative expressions" persistable="0" isFixedValue="0" formula="-njLey33dUi3_-ywtoP-Mg" dim="Dimensionless" quantityType="0" buildMode="Global" />
-            <Parameter id="bDebn7odC0iPrmHb_nl_og" name="Reference concentration" description="Reference concentration" persistable="0" isFixedValue="0" formula="dv7zOp73b0WTuYcppgSzLQ" dim="MolarConcentration" quantityType="0" buildMode="Global" />
-            <Parameter id="2EjLSkzXgE-c9FHUMvwlYQ" name="Relative expression in vascular endothelium (normalized)" description="Relative expression in vasc. Endothelium" persistable="0" isFixedValue="0" formula="JHrA4yvAckaK47yKcz3AzQ" dim="Fraction" quantityType="0" buildMode="Global" />
-            <Parameter id="8wZexxSa9kqBPPZVQJwSdw" name="Relative expression in blood cells (normalized)" description="Relative expression norm in blood cells" persistable="0" isFixedValue="0" formula="VTWOsK6V4k-GXiuqvJXrnQ" dim="Fraction" quantityType="0" buildMode="Global" />
-            <Parameter id="r5ErYfd7u0-gbDu14ev2Dg" name="pKa_Acid_2" description="Largest acid pKa" persistable="0" isFixedValue="0" formula="Sbnk4Q2pMEGgG5FGp4ejOw" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="wSaadiZIDUC4JQ4ujmBBtA" name="pKa_pH_WS_sol_K1" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" formula="IUsyf0braEKr7LkaXT_FrQ" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="815NOVoCo0CUCpQPW91IvA" name="Is triprotic base" description="Is triprotic base" persistable="0" isFixedValue="0" formula="QUAH2vcilUaS2YUIkvoo2w" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="wWFh9mQZ3Uq15gQ5oe6ZIw" name="Molecular weight" description="Molecular weight" persistable="0" isFixedValue="0" formula="JfwdlRpck0KgWE0yDXpHxg" dim="MolecularWeight" quantityType="0" buildMode="Property" />
-            <Parameter id="PNUVdEv5i0qLSXSCqQnGXw" name="pKa value 0" description="pKa value" persistable="0" isFixedValue="0" formula="cKGycGw-ZU-i4ZHl_U--NQ" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="_Hir4aWkPUO-uHyyHQH-Eg" name="pKa value 1" description="pKa value" persistable="0" isFixedValue="0" formula="h3a2xtvmx0aIqORBAR84Og" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="rcEFI2gwGkG9YqRe_fx6Xg" name="pKa value 2" description="pKa value" persistable="0" isFixedValue="0" formula="ON6onyuo2kyAB_7Us0Pe3w" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="vMSY2oPKPEKzo0pbEW3KQw" name="Is strong base" description="Supporting parameter for partition coeffs in RR-Modell (at least one basic pKa&gt;=7)" persistable="0" isFixedValue="0" formula="I7sD611OEUKOjVf0X26jvg" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="Cpamfv5xUkex5JzmcK3qYQ" name="pKa_Acid_1" description="Middle acid pKa" persistable="0" isFixedValue="0" formula="F7AT737nJkq7TOYzkpr6AA" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="h9XnEvibbkOKL-WTrTsYmg" name="Is small molecule" description="Treat compound as small molecule or not (if not, both organ specific and intestinal permeability will be set to zero)" persistable="0" isFixedValue="0" formula="Iecym6toTUSAbox_NWdclw" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="E913ItzVfUyczuEeSihoNw" name="pKa_Acids_Count" description="Number of acidic groups in compound" persistable="0" isFixedValue="0" formula="9o-qjnFMcEO-kj0fbVIzDQ" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="beNpQjGenU-nuzJ3mpNpLA" name="pKa_Base_0" description="Smallest base pKa" persistable="0" isFixedValue="0" formula="yKOGwHZyuE6JN1laXWi3ug" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="3wwETUpbIUKe9DIa-pUOpw" name="pKa_Base_1" description="Middle base pKa" persistable="0" isFixedValue="0" formula="qX2i6gDfdEWt02Xov_fB_A" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="rudVsZFQV02mwc1GICt56Q" name="pKa_Base_2" description="Largest base pKa" persistable="0" isFixedValue="0" formula="ZsXkbxOhsUG5_TLFbrpJXw" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="K6172FvmYEq8G5JCOXkVhw" name="pKa_Bases_Count" description="Number of basic groups in compound" persistable="0" isFixedValue="0" formula="XNV_lbiR5kCzx-KPjKVKQA" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="KXXDimWXMEKt_M9FacDhfA" name="pKa_OneAcid_0" description="Smallest acid pKa for compound with 1 acid group" persistable="0" isFixedValue="0" formula="I3oiWlfH9EWJhUe_FoJypw" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="qIWQZCDmKU2ZVSozTv32AQ" name="pKa_OneBase_0" description="Smallest base pKa for compound with 1 base group" persistable="0" isFixedValue="0" formula="4z9zdsQQh0CtOmMQKH4bBg" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="Vx2eBwxZWEG_lv1ckI3aFA" name="pKa_pH_WS_sol_F1" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" formula="hO1aIJvroUGFwJxZYwXnCA" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="bvXeIqcEI0Oy7DrljnBWhA" name="pKa_pH_WS_sol_F2" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" formula="v8GiWmv5AEmwXQPNdC__xQ" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="SB72Et1oXUO23axcEq6Z5Q" name="pKa_Acid_0" description="Smallest acid pKa" persistable="0" isFixedValue="0" formula="jTEVRUtcK0eZ_EKOho1yTA" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="a4ZPWAGZA0Kx9nCdUot6VA" name="I" description="Number of iodine atoms in molecule" persistable="0" isFixedValue="0" formula="t5h4CuEq40mjohju12rcRQ" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="LO80FVlAnU-HGj8sn0SdRA" name="Compound type 1" description="Compound type (-1: acid, +1: base, 0: neutral)" persistable="0" isFixedValue="0" formula="QpLRJ88OMk2ci5PSIqMRww" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="29GGwbej-kafQfD0ykZSqA" name="Compound type 2" description="Compound type (-1: acid, +1: base, 0: neutral)" persistable="0" isFixedValue="0" formula="enhTyQwCwUSAjTqcbvFw3A" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="4hthKqiKC06hPtfx40QHkA" name="CT_ACID" description="Constant for compound type acid" persistable="0" isFixedValue="0" formula="GLrt_mk2NUKkU7vRHa7EUA" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="PK3LXlAMzEu1TBMkbfnmUg" name="CT_BASE" description="Constant for compound type base" persistable="0" isFixedValue="0" formula="fs9JKYkkTk2mRh8lPWUHNw" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="G2x0xDmynkewMRkc7jeEfQ" name="CT_NEUTRAL" description="Constant for compound type neutral" persistable="0" isFixedValue="0" formula="QHR_9uCZtkaL72G6Za9ivw" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="IGbBtkm90kqNvWNOGGsqgw" name="Effective molecular weight" description="Effective molecular weight" persistable="0" isFixedValue="0" formula="_gdeTZzZNE2hkusderSY2A" dim="MolecularWeight" quantityType="0" buildMode="Property" />
-            <Parameter id="o0nxOSBve0Ob2LvQIcXK2Q" name="F" description="Number of fluorine atoms in molecule" persistable="0" isFixedValue="0" formula="g5CA3dA0rkSy-qYYgiStfw" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="38vpkJLp10mJsGcLt9ulYg" name="Is triprotic acid" description="Is triprotic acid" persistable="0" isFixedValue="0" formula="taHuCeqmk0GU2IODCakDiQ" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="7OXxjGc62UKeK7wWJxnRMg" name="Has halogens" description="Supporting parameter for compound" persistable="0" isFixedValue="0" formula="wvjng6khI02p3G5uOoLOdg" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="fLHh1j-6fkic-lRuBalVPA" name="pKa_pH_WS_sol_K2" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" formula="0bOW5_Bv2Uq_VHADmLS4Fg" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="0bIqjXKrUk6gLwksYN1doQ" name="Is diprotic acid" description="Is diprotic acid" persistable="0" isFixedValue="0" formula="HVP2j-Ho4UOmjbA4SnnTkw" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="lb8gCbrHykyMIkVMN-ecmg" name="Is diprotic base" description="Is diprotic base" persistable="0" isFixedValue="0" formula="0YTKrSdpm0Cux2Yb2MC28g" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="MHv9ZjiPRU-5J2st8SyYVw" name="Is diprotic base monoprotic acid" description="Is diprotic base monoprotic acid" persistable="0" isFixedValue="0" formula="rfnli4GYxkWNJo9QMf91lg" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="95RVO7xL9k6J6ZqcDRQt9Q" name="Is floating in lumen" description="Is floating in lumen" persistable="0" isFixedValue="0" formula="tHz4Re9fakOsvR7GvXlAmA" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="RRJt-zcCx0Gv_8gyih7dRw" name="Is monoprotic acid" description="Is monoprotic acid" persistable="0" isFixedValue="0" formula="Q2fNORRRoEKh11w5napLkw" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="s8M4iVaUzEG3Bu9RW4Y2lw" name="Is monoprotic base" description="Is monoprotic base" persistable="0" isFixedValue="0" formula="8vK7h4P7h0qh5pTBtsQ1WQ" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="JXJUL06zQ0-mmWs-xwbpSQ" name="Is monoprotic base diprotic acid" description="Is monoprotic base diprotic acid" persistable="0" isFixedValue="0" formula="lfT6erIuhEuxat5bsF39-A" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="sPS81KJk5Eybg4YF7UQN1A" name="Is monoprotic base monoprotic acid" description="Is monoprotic base monoprotic acid" persistable="0" isFixedValue="0" formula="4Nqs2BLjG0CcpikW87abDA" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="xYcaUrUR8UOalgcoVuLe2Q" name="Is neutral" description="Supporting parameter for partition coeffs in RR-Modell" persistable="0" isFixedValue="0" formula="yO1a3sxl_Uy-piXJ6MLWFQ" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="fAIxfrsYaEGWTpyFU86zsg" name="pKa_pH_WS_sol_F3" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" formula="AogKch0IZkiIDwUv8nISfw" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="mPYobUOCf0K2vpogfTaSgw" name="pKa_TwoAcids_1" description="Middle acid pKa for compound with 2 acid groups" persistable="0" isFixedValue="0" formula="y3XAaPzNrEiH8y8gCMMMEA" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="Xx7lqv_dg0e0TtexFOFPDQ" name="pKa_pH_WS_sol_K3" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" formula="WIaqbOlyNUyKPsp41PeUjA" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="YaLrvAPslUSGTAIjlSy6wQ" name="pKa_pH_WS_sol_K4" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" formula="AAqIBNaST0yWM12Vc93W4g" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="WhiU-sKUKk6Hol6omE9V4g" name="pKa_pH_WS_sol_K5" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" formula="ERyWKVpZx0Cs1inyglta_A" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="QsIsXsMxdkucjHcd9eGPcA" name="pKa_pH_WS_sol_K6" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" formula="RBMyAucUfki85GoK2w8tzQ" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="PbPlpx5sSUOkDnGdglLK0w" name="pKa_pH_WS_sol_K7" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" formula="4kCZiUPpJUmN5TKPFzHBag" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="zi5nVX-wxEyRdsa_OT_dYA" name="pKa_pH_WS_sol_K8" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" formula="wWyvtiGq9UygnZ3syUlcIg" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="m30CiNeWdEm59agYycdPKQ" name="pKa_ThreeAcids_0" description="Smallest acid pKa for compound with 3 acid groups" persistable="0" isFixedValue="0" formula="0dTm_ONE1E-_xeX-rZXX3w" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="C91YXos13ka_oKTx_ak18Q" name="pKa_ThreeAcids_1" description="Middle acid pKa for compound with 3 acid groups" persistable="0" isFixedValue="0" formula="lteSI2UfD0e-7Yz7bP85kQ" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="t6UAHFtKEUaeEl8gOJJ7hw" name="pKa_ThreeBases_0" description="Smallest base pKa for compound with 3 base groups" persistable="0" isFixedValue="0" formula="45HlZ2Y860WlJ2jv7Jd-1g" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="oDR3hlvNd0SIDZc5Li6vrg" name="pKa_TwoAcids_0" description="Smallest acid pKa for compound with 2 acid groups" persistable="0" isFixedValue="0" formula="wjpBIMzS90-stcW-3OoAeQ" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="m1xb1uCwHUCiilisuRzcxw" name="pKa_TwoBases_0" description="Smallest base pKa for compound with 2 base groups" persistable="0" isFixedValue="0" formula="PC25kBbN3kG0_AVVajJHMQ" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="sHharshDuUONaWdEULMigw" name="pKa_TwoBases_1" description="Middle base pKa for compound with 2 base groups" persistable="0" isFixedValue="0" formula="_W32QW30jUGR-IEpVsKOyg" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="9djGzjPLkEyMXu4g2RAs_A" name="Solubility gain per charge" description="Supporting parameter for calculation of pKa- and pH- dependent values of intestinal solubilty" persistable="0" isFixedValue="0" formula="rKYpQjskI0K0nELhhXLeSQ" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="YWGaJqNpyEKdnQPwU90dGA" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" persistable="0" isFixedValue="0" formula="x3heyoTGaEm5cpbYuszt0w" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="-nDWekxM40uPC2FGSBcvRw" name="Total oral drug mass" description="Total oral drug mass" persistable="0" isFixedValue="0" formula="eIfckw33xESYmM9vr3bGwg" dim="Amount" quantityType="0" buildMode="Property" />
-            <Parameter id="M8ycTIrjc06xOPSfob77eQ" name="pKa_ThreeBases_1" description="Middle base pKa for compound with 3 base groups" persistable="0" isFixedValue="0" formula="vHLCNrQndEaYStB1-XRs6w" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="PJInKIb4skKAvJPz8IdaLA" name="Cl" description="Number of chlorine atoms in molecule" persistable="0" isFixedValue="0" formula="Y7-QToKkgESE21re-TRinw" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="2lIKBM3W6U6OCTJYZHsfOg" name="Br" description="Number of bromine atoms in molecule" persistable="0" isFixedValue="0" formula="n0cshJiOrE2ucH9wRr0arA" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="cDqDUrtYykuNJkg_lKXs4w" name="Compound type 0" description="Compound type (-1: acid, +1: base, 0: neutral)" persistable="0" isFixedValue="0" formula="u7CxvHPMFEW439cTFzX7Xg" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="x8bxKAd-o0q6D7gc0Zn98A" name="base_For_KaPL_Factor" description="Supporting parameter for calculation of pKa- and pH- dependent values of KaPL" persistable="0" isFixedValue="0" formula="DwHFzbqAh0ydSNsRqUUNuw" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="wa4OuqHF1EmkOC5M2z0Ajw" name="base_For_logD_Factor" description="Supporting parameter for calculation of pKa- and pH- dependent logD" persistable="0" isFixedValue="0" formula="yWJtmBkUxkekCEdRonPpbQ" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="PfiMub-lQk6M0p653O5v2A" name="base_For_P_cell_Factor" description="Supporting parameter for calculation of pKa- and pH- dependent permeability to/from cells" persistable="0" isFixedValue="0" formula="ZawC_MakvUKN8kCWmMKyfA" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="__gf91EufEit33dXTW0XnQ" name="base_For_Pint_Factor" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="YdILafHfLEym8xdyYYU6Cw" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="ccJIpuaaMUOnvtO_KrYXKg" name="Lipophilicity" description="Model dependent lipophilicity measure: LogMA / LogP / ..." persistable="0" isFixedValue="0" formula="UkvgsZgZ70aq5EPUssO9Cw" dim="Lipophilicity" quantityType="0" buildMode="Property" />
-            <Parameter id="rHdBrrxjF0mdn3ii44mZ_Q" name="Fraction unbound (plasma)" description="Fraction unbound in plasma" persistable="0" isFixedValue="0" formula="guds0nRfJk-0oNPLxjI3gA" dim="Fraction" quantityType="0" buildMode="Property" />
-            <Parameter id="-Wu345Xqj0iFcmU9EiXPAg" name="Solubility at reference pH" description="Solubility at reference pH" persistable="0" isFixedValue="0" formula="39-CVPS_sEmwjJeMGDcepw" dim="Concentration" quantityType="0" buildMode="Property" />
-            <Parameter id="gFdD9rn9LE6ra9n1VER9Ng" name="Reference pH" description="Reference pH" persistable="0" isFixedValue="0" formula="gb7HX6pRsUCXJZxUpKgJqQ" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="4bt2k-m3zEuTs9hK4MvMEA" name="Permeability" description="Permeability" persistable="0" isFixedValue="0" formula="Zx90sdkJikGNbUnct14wwg" dim="Velocity" quantityType="0" buildMode="Property" />
-            <Parameter id="Qtw589wMw0aMEd4woT3Apw" name="Specific intestinal permeability (transcellular)" description="Specific intestinal permeability (transcellular)" persistable="0" isFixedValue="0" formula="KKdfVw7fPUKjSeGnkCAx6Q" dim="Velocity" quantityType="0" buildMode="Property" />
-            <Parameter id="RvFmB_RRZk2j83gVYZB1LQ" name="Partition coefficient (water/protein)" description="Partition coefficient water to protein" persistable="0" isFixedValue="0" formula="FOySywJR2ke5EkXXhNUriQ" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="MVYaSLWPpk24e7c0bMiE1g" name="Treat precipitated drug as" description="Treat precipitated drug as either soluble or insoluble" persistable="0" isFixedValue="0" formula="Ckczy3zvBk-zoHjoc7VJcg" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="NETIYG2fXEKx6Vzab9swGQ" name="Aqueous diffusion coefficient" description="Aqueous diffusion coefficient&#xA;of the drug" persistable="0" isFixedValue="0" formula="LDumG6rqjEexHToYOfIjrQ" dim="DiffusionCoefficient" quantityType="0" buildMode="Property" />
-            <Parameter id="OvEDxcelak6n_sEECxcTJg" name="Density (drug)" description="Density of drug material" persistable="0" isFixedValue="0" formula="CX-B6geNN0aF5WwUi96YJQ" dim="Density" quantityType="0" buildMode="Property" />
-            <Parameter id="q9GXGRYRxk2e68PpE22Tbw" name="Immediately dissolve particles smaller than" description="Threshold for the particle radius of immediate dissolution" persistable="0" isFixedValue="0" formula="tSa49A3xTkCVKxp6Vr-TlQ" dim="Nanolength" quantityType="0" buildMode="Property" />
-            <Parameter id="iYIzhJWtuUGRlzYmaeAX6A" name="Radius (solute)" description="Solute radius" persistable="0" isFixedValue="0" formula="433yTHoK0UOv1dgmhHKaXQ" dim="Nanolength" quantityType="0" buildMode="Property" />
-            <Parameter id="TbtIDhMkK0WigQiz_95Fag" name="Kd (FcRn)" description="Dissociation constant for binding of drug to FcRn" persistable="0" isFixedValue="0" formula="ctkMGxuzfUCHUguR1xVajw" dim="MolarConcentration" quantityType="0" buildMode="Property" />
-            <Parameter id="6irsQtPCcEyX6aHNMmN3Jg" name="Use pH- and pKa-dependent penalty factor for charged molecule fraction" description="Penalty factor for charged molecule fraction is used for &quot;Intestinal permeability (transcellular)&quot; only" persistable="0" isFixedValue="0" formula="vsG3PpYgpk-peZNm2Odl8w" dim="Dimensionless" quantityType="0" buildMode="Property" />
-          </Children>
-        </Container>
-        <Container id="9iCu3db3UEuE1GjqI2t0hw" name="Drug-Cyp Metabolite" mode="Logical" containerType="Molecule">
-          <Children>
-            <Parameter id="U7q89qGm0UOa7WuZiLxWhw" name="pKa_Acid_2" description="Largest acid pKa" persistable="0" isFixedValue="0" formula="Sbnk4Q2pMEGgG5FGp4ejOw" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="PZys8SayIES6Yb5Gfkcv_g" name="pKa_pH_WS_sol_K1" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" formula="IUsyf0braEKr7LkaXT_FrQ" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="468AJbpyOkCxocTIOKJnuA" name="Is triprotic base" description="Is triprotic base" persistable="0" isFixedValue="0" formula="QUAH2vcilUaS2YUIkvoo2w" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="CKp_K_HxfEe0i-Nz-PjQ5A" name="Molecular weight" description="Molecular weight" persistable="0" isFixedValue="0" formula="YCl7Uy03XE-NtdsQigSn-w" dim="MolecularWeight" quantityType="0" buildMode="Property" />
-            <Parameter id="Rovv0sJdRkORYcB1QMhMzA" name="pKa value 0" description="pKa value" persistable="0" isFixedValue="0" formula="D8KnA6zGLU2Q_wWCDwiQQg" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="_Vv_MkiQW02KvQSRChGVLg" name="pKa value 1" description="pKa value" persistable="0" isFixedValue="0" formula="jRPD6D6BXka2NUCl70BsvQ" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="WOGQ8AJpRkWaSsxm-Nidlw" name="pKa value 2" description="pKa value" persistable="0" isFixedValue="0" formula="owZTACJuUkeBXbzKQByazQ" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="1KCleo4lHk6PMzO2YbXaFQ" name="Is strong base" description="Supporting parameter for partition coeffs in RR-Modell (at least one basic pKa&gt;=7)" persistable="0" isFixedValue="0" formula="I7sD611OEUKOjVf0X26jvg" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="EIR-cfWyUEybJp0Urg5yXQ" name="pKa_Acid_1" description="Middle acid pKa" persistable="0" isFixedValue="0" formula="F7AT737nJkq7TOYzkpr6AA" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="N3MsXr8tPUWQXMONKn_cwA" name="Is small molecule" description="Treat compound as small molecule or not (if not, both organ specific and intestinal permeability will be set to zero)" persistable="0" isFixedValue="0" formula="ItG6ANZ5jEueWZaJl7GBhQ" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="fAHnnpsxvkm9pJp5MfJ69Q" name="pKa_Acids_Count" description="Number of acidic groups in compound" persistable="0" isFixedValue="0" formula="9o-qjnFMcEO-kj0fbVIzDQ" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="XIlCluA6WkuHX2-CbM67XQ" name="pKa_Base_0" description="Smallest base pKa" persistable="0" isFixedValue="0" formula="yKOGwHZyuE6JN1laXWi3ug" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="BSDQDyJPKE6I8VJK4DSbuQ" name="pKa_Base_1" description="Middle base pKa" persistable="0" isFixedValue="0" formula="qX2i6gDfdEWt02Xov_fB_A" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="UhQ-aH_1hk2-IDkAmrhetg" name="pKa_Base_2" description="Largest base pKa" persistable="0" isFixedValue="0" formula="ZsXkbxOhsUG5_TLFbrpJXw" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="7bVAKBaIW0u9PFOjO0UTbQ" name="pKa_Bases_Count" description="Number of basic groups in compound" persistable="0" isFixedValue="0" formula="XNV_lbiR5kCzx-KPjKVKQA" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="zsvXOv7gJkyK7Ytnjtqszg" name="pKa_OneAcid_0" description="Smallest acid pKa for compound with 1 acid group" persistable="0" isFixedValue="0" formula="I3oiWlfH9EWJhUe_FoJypw" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="q4SRRGumZ0aTP5k1b9ODRg" name="pKa_OneBase_0" description="Smallest base pKa for compound with 1 base group" persistable="0" isFixedValue="0" formula="4z9zdsQQh0CtOmMQKH4bBg" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="nQE0ksX26k670rnDvnUh4A" name="pKa_pH_WS_sol_F1" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" formula="hO1aIJvroUGFwJxZYwXnCA" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="b5ZXzpY5EEec7496PXkqjA" name="pKa_pH_WS_sol_F2" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" formula="v8GiWmv5AEmwXQPNdC__xQ" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="468DOHItNUyQ3nkS40lrUQ" name="pKa_Acid_0" description="Smallest acid pKa" persistable="0" isFixedValue="0" formula="jTEVRUtcK0eZ_EKOho1yTA" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="_CVDucQBxke1JeWLFZN1kg" name="I" description="Number of iodine atoms in molecule" persistable="0" isFixedValue="0" formula="UGFaaJI9D0-DiVSJGZF6Dg" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="BSmdob9ItUSP5AZfnNM1NQ" name="Compound type 1" description="Compound type (-1: acid, +1: base, 0: neutral)" persistable="0" isFixedValue="0" formula="w5dUjbGY_kWZSRqoLP3cNQ" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="LAk_va5RAUK00EX3HCXVKA" name="Compound type 2" description="Compound type (-1: acid, +1: base, 0: neutral)" persistable="0" isFixedValue="0" formula="zrPVYkzZqUWLum8Ehbyu9A" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="ODPFX17eYESUKiC0jzAQYA" name="CT_ACID" description="Constant for compound type acid" persistable="0" isFixedValue="0" formula="fdDi6zAdL0Ge8USPja_NiQ" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="CtjyGpPSeEGx2V7yE_3mxg" name="CT_BASE" description="Constant for compound type base" persistable="0" isFixedValue="0" formula="vuu7KRfjGkal8rJgp4JiqQ" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="faZYOG_qJEGzAct2Z4IwPw" name="CT_NEUTRAL" description="Constant for compound type neutral" persistable="0" isFixedValue="0" formula="PxJxN_b3vUeG9uJZWxg9tw" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="WxLj3IevCUqea3nbRtUJlA" name="Effective molecular weight" description="Effective molecular weight" persistable="0" isFixedValue="0" formula="_gdeTZzZNE2hkusderSY2A" dim="MolecularWeight" quantityType="0" buildMode="Property" />
-            <Parameter id="bcar-goTQUaLKPi0qj9yAA" name="F" description="Number of fluorine atoms in molecule" persistable="0" isFixedValue="0" formula="RM6oRVUR9k-8nd3sT8Y4pQ" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="KFALkoEnZU6xLhZ5E0sSlg" name="Is triprotic acid" description="Is triprotic acid" persistable="0" isFixedValue="0" formula="taHuCeqmk0GU2IODCakDiQ" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="qNn0EHxHAUSujvd2RUFUyA" name="Has halogens" description="Supporting parameter for compound" persistable="0" isFixedValue="0" formula="wvjng6khI02p3G5uOoLOdg" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="UM5jYlXN4UqXWYScRnBQGg" name="pKa_pH_WS_sol_K2" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" formula="0bOW5_Bv2Uq_VHADmLS4Fg" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="jVeQVDcj1kGDUHq61bKcmA" name="Is diprotic acid" description="Is diprotic acid" persistable="0" isFixedValue="0" formula="HVP2j-Ho4UOmjbA4SnnTkw" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="yw4v6DsXQEy_p31wtj0kQA" name="Is diprotic base" description="Is diprotic base" persistable="0" isFixedValue="0" formula="0YTKrSdpm0Cux2Yb2MC28g" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="FOzMuYoRp0yIqNaVrlB-aw" name="Is diprotic base monoprotic acid" description="Is diprotic base monoprotic acid" persistable="0" isFixedValue="0" formula="rfnli4GYxkWNJo9QMf91lg" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="IX-ugprS2UORM787R-n3TQ" name="Is floating in lumen" description="Is floating in lumen" persistable="0" isFixedValue="0" formula="wOH7MONFC02Q3Z-9d54yWw" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="XSahzeHcok-MnDtIgOGcOQ" name="Is monoprotic acid" description="Is monoprotic acid" persistable="0" isFixedValue="0" formula="Q2fNORRRoEKh11w5napLkw" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="BMWnNcb32UmPQnpnrqGIbw" name="Is monoprotic base" description="Is monoprotic base" persistable="0" isFixedValue="0" formula="8vK7h4P7h0qh5pTBtsQ1WQ" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="ycAHxRaI70-RvpU6w8ak8Q" name="Is monoprotic base diprotic acid" description="Is monoprotic base diprotic acid" persistable="0" isFixedValue="0" formula="lfT6erIuhEuxat5bsF39-A" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="LUH8akick0uELc1gjxUtzg" name="Is monoprotic base monoprotic acid" description="Is monoprotic base monoprotic acid" persistable="0" isFixedValue="0" formula="4Nqs2BLjG0CcpikW87abDA" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="-cS7Bn-9LUezeaLlYy_Vqg" name="Is neutral" description="Supporting parameter for partition coeffs in RR-Modell" persistable="0" isFixedValue="0" formula="yO1a3sxl_Uy-piXJ6MLWFQ" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="St33sr-Z5kOFRFjmqqbzaQ" name="pKa_pH_WS_sol_F3" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" formula="AogKch0IZkiIDwUv8nISfw" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="G70sEtAFaECXcwr0TWL17Q" name="pKa_TwoAcids_1" description="Middle acid pKa for compound with 2 acid groups" persistable="0" isFixedValue="0" formula="y3XAaPzNrEiH8y8gCMMMEA" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="lgrrF_xS_0ahLdIzQrI80g" name="pKa_pH_WS_sol_K3" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" formula="WIaqbOlyNUyKPsp41PeUjA" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="dGjuwSyHeUOJzBRiRjNfjw" name="pKa_pH_WS_sol_K4" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" formula="AAqIBNaST0yWM12Vc93W4g" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="15S4UC9tlkWqwPpViblKzQ" name="pKa_pH_WS_sol_K5" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" formula="ERyWKVpZx0Cs1inyglta_A" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="C5TvJh0Z4Ea-atA12su_ww" name="pKa_pH_WS_sol_K6" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" formula="RBMyAucUfki85GoK2w8tzQ" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="_OaiF6pDSUaDuleXKNOqWA" name="pKa_pH_WS_sol_K7" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" formula="4kCZiUPpJUmN5TKPFzHBag" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="vnH5IGwFfU6ZQ270GAeu7g" name="pKa_pH_WS_sol_K8" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" formula="wWyvtiGq9UygnZ3syUlcIg" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="spffaQhUkEa3uMoJuy10BA" name="pKa_ThreeAcids_0" description="Smallest acid pKa for compound with 3 acid groups" persistable="0" isFixedValue="0" formula="0dTm_ONE1E-_xeX-rZXX3w" dim="Dimensionless" quantityType="0" buildMode="Property" />
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-            <Parameter id="rGqiuKpWdkSrUxsdxuBSGw" name="pKa_ThreeBases_0" description="Smallest base pKa for compound with 3 base groups" persistable="0" isFixedValue="0" formula="45HlZ2Y860WlJ2jv7Jd-1g" dim="Dimensionless" quantityType="0" buildMode="Property" />
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-            <Parameter id="yBPtU3u32Ey31a2hllS5nA" name="Cl" description="Number of chlorine atoms in molecule" persistable="0" isFixedValue="0" formula="hvj2NEeLC0miRo7w_9Th7g" dim="Dimensionless" quantityType="0" buildMode="Property" />
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-            <Parameter id="KzFXkYDuGEi_pMlFWM4Lxw" name="base_For_KaPL_Factor" description="Supporting parameter for calculation of pKa- and pH- dependent values of KaPL" persistable="0" isFixedValue="0" formula="bMryUA9zmUi43YIdb5-4Dw" dim="Dimensionless" quantityType="0" buildMode="Property" />
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-            <Parameter id="BO-W5sfSZ0yHEFvxdhfOcQ" name="base_For_Pint_Factor" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="sYAc10RtCkqGy-nWSqpC5A" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="HfljmkIxZkifCEPs0rmAqw" name="Lipophilicity" description="Model dependent lipophilicity measure: LogMA / LogP / ..." persistable="0" isFixedValue="0" formula="1C8SGvEx7k2xUpdg-or5Sw" dim="Lipophilicity" quantityType="0" buildMode="Property" />
-            <Parameter id="6c9bLWsYaEyGcSflo5fLzg" name="Fraction unbound (plasma)" description="Fraction unbound in plasma" persistable="0" isFixedValue="0" formula="4zoz5-ofkEKJZQSNOsoEPw" dim="Fraction" quantityType="0" buildMode="Property" />
-            <Parameter id="oeTwSfeolEGByw3wBku_tA" name="Solubility at reference pH" description="Solubility at reference pH" persistable="0" isFixedValue="0" formula="jS1wIdaRvEO7BXQBm7qdZg" dim="Concentration" quantityType="0" buildMode="Property" />
-            <Parameter id="FH4fCNtZhE-B6zupPz4dGg" name="Reference pH" description="Reference pH" persistable="0" isFixedValue="0" formula="-dYdQusSzUKvxbNqhsenuQ" dim="Dimensionless" quantityType="0" buildMode="Property" />
-            <Parameter id="qwJnaW-5LUul8SKsjZfo7g" name="Permeability" description="Permeability" persistable="0" isFixedValue="0" formula="Zx90sdkJikGNbUnct14wwg" dim="Velocity" quantityType="0" buildMode="Property" />
-            <Parameter id="twM6PXa8uESqIi0vKFt0ug" name="Specific intestinal permeability (transcellular)" description="Specific intestinal permeability (transcellular)" persistable="0" isFixedValue="0" formula="KKdfVw7fPUKjSeGnkCAx6Q" dim="Velocity" quantityType="0" buildMode="Property" />
-            <Parameter id="4SoYqSkRHEOtCBI4g6QBxw" name="Partition coefficient (water/protein)" description="Partition coefficient water to protein" persistable="0" isFixedValue="0" formula="FOySywJR2ke5EkXXhNUriQ" dim="Dimensionless" quantityType="0" buildMode="Property" />
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-            <Parameter id="jbM2TGOz80-R1zJsUVsUFw" name="Immediately dissolve particles smaller than" description="Threshold for the particle radius of immediate dissolution" persistable="0" isFixedValue="0" formula="xTSfGMa5EkGPgYsyXkzFTA" dim="Nanolength" quantityType="0" buildMode="Property" />
-            <Parameter id="TGiGyDsfQEGxziRvmJnnhw" name="Radius (solute)" description="Solute radius" persistable="0" isFixedValue="0" formula="433yTHoK0UOv1dgmhHKaXQ" dim="Nanolength" quantityType="0" buildMode="Property" />
-            <Parameter id="S9yaQeNMvUmQkhQsezazGA" name="Kd (FcRn)" description="Dissociation constant for binding of drug to FcRn" persistable="0" isFixedValue="0" formula="kyAK377EvUeSGAc6uAaGUg" dim="MolarConcentration" quantityType="0" buildMode="Property" />
-            <Parameter id="soglHt_BNkePJcB5-27JYw" name="Use pH- and pKa-dependent penalty factor for charged molecule fraction" description="Penalty factor for charged molecule fraction is used for &quot;Intestinal permeability (transcellular)&quot; only" persistable="0" isFixedValue="0" formula="HGRyJ_pOFkWGbuJkwvb7gQ" dim="Dimensionless" quantityType="0" buildMode="Property" />
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-            <Parameter id="LqM90Yk1m06Q36twK5xMUQ" name="Enzyme concentration" description="Enzyme concentration in organ of individual where the process took place or in the assay where the experiment was performed" persistable="0" isFixedValue="0" formula="4hVqBbH3v0OtaXVOFibldA" dim="MolarConcentration" quantityType="0" buildMode="Global" />
-            <Parameter id="U3e0DgxCSkmgMifD_87WoA" name="CLspec/[Enzyme]" description="Specific clearance normalized to the enzyme concentration" persistable="0" isFixedValue="0" formula="qT0LHJM0U0isFhoTWsS-Nw" dim="SpecificClearancePerProtein" quantityType="0" buildMode="Global" />
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-            <Parameter id="z6VoHj-tDUGHIpXutzQnnA" name="Intrinsic clearance" description="Intrinsic clearance" persistable="0" isFixedValue="0" formula="pc-j4clDVUWmgG3-ndZYJA" dim="Flow (volume)" quantityType="0" buildMode="Global" />
-            <Parameter id="fnzxvvaq8UeiWB9J-hBeIQ" name="Specific clearance" description="Intrinsic clearance normalized to the volume where the process occurs" persistable="0" isFixedValue="0" formula="wufxjjm18Eu6VXtk9hlSnQ" dim="InversedTime" quantityType="0" buildMode="Global" />
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-                  <Tags>
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-                    <Tag value="Application" />
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-                      <Tags>
-                        <Tag value="ProtocolSchemaItem" />
-                        <Tag value="Application" />
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-                      </Tags>
-                      <Children>
-                        <Parameter id="e6PHXMhXDk-NnrWwii2vGw" name="Start time" description="Start time of application" persistable="0" isFixedValue="0" formula="zA_1f7JbYESjLbYwJaLgLA" dim="Time" quantityType="0" />
-                        <Parameter id="cZ6a75MHC0uTY-61zNe2mg" name="DrugMass" description="Drug mass of application" persistable="0" isFixedValue="0" formula="VILBvjHcy0KKcJswRCdu3w" dim="Amount" quantityType="0" />
-                        <Parameter id="PD6QBBrGwESB6yW-cJ6oeg" name="DosePerBodyWeight" description="Dose" persistable="0" isFixedValue="0" formula="_psR4FSvG0KJg4qSi-61VQ" dim="DosePerBodyWeight" quantityType="0" />
-                        <Parameter id="biV-ic3z4km4-mcA4fTGFA" name="Dose" description="Dose" persistable="0" isFixedValue="0" formula="b_Do5MCsHEuLK6bsQHT61g" dim="MassAmount" quantityType="0" />
-                        <Parameter id="DihOwYuSP0aYCCOFCtM34A" name="Amount of water" description="Amount of water" persistable="0" isFixedValue="0" formula="nHg75W6x7ESMfd4SYUedQw" dim="Volume" quantityType="0" />
-                        <Parameter id="W8azLPoybUqY41HRqvxjIA" name="Volume of water/body weight" description="Volume of water per body weight co-administered with the drug" persistable="0" isFixedValue="0" formula="bBcxWxcC9EmsIKW0HymgeQ" dim="VolumePerBodyWeight" quantityType="0" />
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-                      <Children>
-                        <Parameter id="wz6B4PDe20CZHo2DPWZL2w" name="Concentration" persistable="0" isFixedValue="0" formula="NTD_p3_xGkWGgb7EHoyuUQ" dim="MolarConcentration" quantityType="0" />
-                        <Observer id="9tiOjNMz9U6wiL28Vliy0A" name="Concentration in container" description="Concentration of the molecule" persistable="0" isFixedValue="0" formula="of8oNwjKxEK0toQ4YK155Q" dim="MolarConcentration" quantityType="Drug, Observer" />
-                      </Children>
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-                  </Children>
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-              </Children>
-            </EventGroup>
-            <Parameter id="qpbHFrvEr0qDSHpHqHmxag" name="TotalDrugMass" persistable="0" isFixedValue="0" formula="Efn4dPpRq0eZEdtNK5FTbg" dim="Amount" quantityType="0" />
-          </Children>
-        </EventGroup>
-      </Children>
-    </Root>
-    <FormulaCache>
-      <Formulas>
-        <Formula id="Qb7nQ3HRT0Ce_cS3ciSIZg" name="PARAM_BMI" dim="BMI" formula="Height&gt;0 ? BW / (Height / 100)^2 : 0" origin="BMI.PARAM_BMI">
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-        </Formula>
-        <Formula id="tSobV-ANhE6XfXxMiDroBw" name="PARAM_BW" dim="Dimensionless" formula="V_art + V_sto + V_sin + V_lin + V_pan + V_spl + V_liv + V_lng + V_mus + V_fat + V_skn + V_kid + V_brn + V_hrt + V_bon + V_tes + V_pve + V_ven" origin="Individual_PKSim.PARAM_BW">
-          <Paths>
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-          </Paths>
-        </Formula>
-        <Formula id="DS1ik1gi-ku0dD95TvEB1Q" name="PARAM_VolumePlasma" dim="Volume" formula="(1 - HCT) * (V_ven + V_art + V_pve + f_vas_bon * V_bon + f_vas_brn * V_brn + f_vas_fat * V_fat + f_vas_tes * V_tes + f_vas_hrt * V_hrt + f_vas_kid * V_kid + f_vas_lin * V_lin + f_vas_liv * V_liv + f_vas_lng * V_lng + f_vas_mus * V_mus + f_vas_pan * V_pan + f_vas_skn * V_skn + f_vas_sin * V_sin + f_vas_spl * V_spl + f_vas_sto * V_sto)" origin="Individual_PKSim.PARAM_VolumePlasma">
-          <Paths>
-            <Path path="47" as="48" />
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-          </Paths>
-        </Formula>
-        <Formula id="p7nX_wgFY0SMhFsdWkKBUA" name="PARAM_PostMenstrualAge" dim="AgeInWeeks" formula="Age* 365/7 + 40" origin="GFR_Calculation.PARAM_PostMenstrualAge">
-          <Paths>
-            <Path path="79" as="80" dim="80" />
-          </Paths>
-        </Formula>
-        <ConstantFormula id="V-_Btes0hEWyOE5vW_LC3w" dim="Dimensionless" value="1" />
-        <ConstantFormula id="7SEvxzmn_UisboTs_-_8Jg" dim="Dimensionless" value="950000" />
-        <Formula id="UcTkWtzk2EiVNhBp6pSkqA" name="PARAM_CLSpec_endosomal_global" dim="Dimensionless" formula="K_uptake-K_rec&gt;=0 ? K_uptake-K_rec : 0" origin="Individual_PKSim.PARAM_CLSpec_endosomal_global">
-          <Paths>
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-        <Map s="..|Volume of protein container" id="138" />
-        <Map s="ProteinContainerVolume" id="139" />
-        <Map s="T1|Cyp|Reference concentration" id="140" />
-        <Map s="AF" id="141" />
-        <Map s="Ontogeny factor" id="142" />
-        <Map s="f_onto" id="143" />
-        <Map s="Relative expression out." id="144" />
-        <Map s="rel_exp_out" id="145" />
-        <Map s="T1|Applications|TotalDrugMass" id="146" />
-        <Map s="TotalDrugMass" id="147" />
-        <Map s="..|Cyp|Concentration" id="148" />
-        <Map s="CP" id="149" />
-        <Map s="..|Drug" id="150" />
-        <Map s="..|Drug|Partition coefficient (water/container)" id="151" />
-        <Map s="K_water" id="152" />
-        <Map s="T1|Cyp-ME|CLspec/[Enzyme]" id="153" />
-        <Map s="CLspecPerEnzyme" id="154" />
-        <Map s="SpecificClearancePerProtein" id="155" />
-        <Map s="T1|Drug|Partition coefficient (blood cells/plasma)" id="156" />
-        <Map s="K_rbc" id="157" />
-        <Map s="T1|Cyp|Relative expression in blood cells (normalized)" id="158" />
-        <Map s="rel_exp_bc_norm" id="159" />
-        <Map s="T1|Cyp|Relative expression in blood cells" id="160" />
-        <Map s="rel_exp_bc" id="161" />
-        <Map s="..|..|BloodCells|Drug|Concentration" id="162" />
-        <Map s="C_bc" id="163" />
-        <Map s="..|..|Plasma|Drug|Concentration" id="164" />
-        <Map s="..|Gallbladder ejection half-time" id="165" />
-        <Map s="EHC_HalfTime" id="166" />
-        <Map s="Time" id="167" />
-        <Map s="..|Specific blood flow rate" id="168" />
-        <Map s="Qspec" id="169" />
-        <Map s="Flow (volume) per organ weight" id="170" />
-        <Map s="T1|Organism|Thickness (endothelium)" id="171" />
-        <Map s="d_endo" id="172" />
-        <Map s="T1|Neighborhoods|Bone_pls_Bone_int|Surface area (plasma/interstitial)" id="173" />
-        <Map s="SA_pls_int" id="174" />
-        <Map s="Surface" id="175" />
-        <Map s="..|Fraction interstitial" id="176" />
-        <Map s="f_int" id="177" />
-        <Map s="..|Fraction vascular" id="178" />
-        <Map s="V_org" id="179" />
-        <Map s="..|..|Fraction interstitial" id="180" />
-        <Map s="T1|Organism|pH (interstitial)" id="181" />
-        <Map s="pH_int" id="182" />
-        <Map s="T1|Neighborhoods|Bone_int_Bone_cell|Drug|Partition coefficient (interstitial/water)" id="183" />
-        <Map s="K_water_int" id="184" />
-        <Map s="..|..|Fraction intracellular" id="185" />
-        <Map s="f_cell" id="186" />
-        <Map s="T1|Neighborhoods|Bone_int_Bone_cell|Drug|Partition coefficient (intracellular/water)" id="187" />
-        <Map s="K_water_cell" id="188" />
-        <Map s="..|..|Interstitial|Drug|Concentration" id="189" />
-        <Map s="C_int" id="190" />
-        <Map s="..|..|Interstitial|Drug|Partition coefficient (water/container)" id="191" />
-        <Map s="..|..|Intracellular|Drug|Concentration" id="192" />
-        <Map s="C_cell" id="193" />
-        <Map s="..|..|Intracellular|Drug|Partition coefficient (water/container)" id="194" />
-        <Map s="T1|Neighborhoods|Brain_pls_Brain_int|Surface area (plasma/interstitial)" id="195" />
-        <Map s="T1|Neighborhoods|Brain_int_Brain_cell|Drug|Partition coefficient (interstitial/water)" id="196" />
-        <Map s="T1|Neighborhoods|Brain_int_Brain_cell|Drug|Partition coefficient (intracellular/water)" id="197" />
-        <Map s="T1|Neighborhoods|Fat_pls_Fat_int|Surface area (plasma/interstitial)" id="198" />
-        <Map s="GeometricDeviation" id="199" />
-        <Map s="T1|Neighborhoods|Fat_int_Fat_cell|Drug|Partition coefficient (interstitial/water)" id="200" />
-        <Map s="T1|Neighborhoods|Fat_int_Fat_cell|Drug|Partition coefficient (intracellular/water)" id="201" />
-        <Map s="T1|Neighborhoods|Gonads_pls_Gonads_int|Surface area (plasma/interstitial)" id="202" />
-        <Map s="T1|Neighborhoods|Gonads_int_Gonads_cell|Drug|Partition coefficient (interstitial/water)" id="203" />
-        <Map s="T1|Neighborhoods|Gonads_int_Gonads_cell|Drug|Partition coefficient (intracellular/water)" id="204" />
-        <Map s="T1|Neighborhoods|Heart_pls_Heart_int|Surface area (plasma/interstitial)" id="205" />
-        <Map s="T1|Neighborhoods|Heart_int_Heart_cell|Drug|Partition coefficient (interstitial/water)" id="206" />
-        <Map s="T1|Neighborhoods|Heart_int_Heart_cell|Drug|Partition coefficient (intracellular/water)" id="207" />
-        <Map s="T1|Neighborhoods|Kidney_pls_Kidney_int|Surface area (plasma/interstitial)" id="208" />
-        <Map s="T1|Organism|Estimated gestational age" id="209" />
-        <Map s="PMA" id="210" />
-        <Map s="AgeInWeeks" id="211" />
-        <Map s="T1|Organism|Kidney|fGFRpremat" id="212" />
-        <Map s="GFR_premat" id="213" />
-        <Map s="T1|Organism|Kidney|GFRmat" id="214" />
-        <Map s="GFR_mat" id="215" />
-        <Map s="Flow (volume)" id="216" />
-        <Map s="T1|Organism|Kidney|Hill coefficient for GFR" id="217" />
-        <Map s="Hill" id="218" />
-        <Map s="T1|Organism|Kidney|TM50 for GFR" id="219" />
-        <Map s="TM50" id="220" />
-        <Map s="T1|Organism|Kidney|Volume (standard kidney)" id="221" />
-        <Map s="V_kid_std" id="222" />
-        <Map s="T1|Neighborhoods|Kidney_int_Kidney_cell|Drug|Partition coefficient (interstitial/water)" id="223" />
-        <Map s="T1|Neighborhoods|Kidney_int_Kidney_cell|Drug|Partition coefficient (intracellular/water)" id="224" />
-        <Map s="..|Geometric surface area" id="225" />
-        <Map s="Area" id="226" />
-        <Map s="..|Thickness of gut wall" id="227" />
-        <Map s="d" id="228" />
-        <Map s="..|Liquid" id="229" />
-        <Map s="Liquid" id="230" />
-        <Map s="..|Fraction of geometric volume filled with liquid" id="231" />
-        <Map s="FillLevel" id="232" />
-        <Map s="..|Distal radius" id="233" />
-        <Map s="r2" id="234" />
-        <Map s="..|Length" id="235" />
-        <Map s="L" id="236" />
-        <Map s="..|Proximal radius" id="237" />
-        <Map s="r1" id="238" />
-        <Map s="..|Gastric emptying time" id="239" />
-        <Map s="GET" id="240" />
-        <Map s="..|Fractional steady state fill level" id="241" />
-        <Map s="SteadyStateFillLevel" id="242" />
-        <Map s="..|FillLevelFlag" id="243" />
-        <Map s="FillLevelFlag" id="244" />
-        <Map s="..|Liquid transfer rate" id="245" />
-        <Map s="LT_sto" id="246" />
-        <Map s="Rate" id="247" />
-        <Map s="..|Secretion of liquid" id="248" />
-        <Map s="Inflow" id="249" />
-        <Map s="..|..|OralApplicationsEnabled" id="250" />
-        <Map s="OralApplicationsEnabled" id="251" />
-        <Map s="..|Intestinal transit rate (absolute)" id="252" />
-        <Map s="w" id="253" />
-        <Map s="..|..|Duodenum|FillLevelFlag" id="254" />
-        <Map s="FillLevelFlagNext" id="255" />
-        <Map s="..|pH in fasted state" id="256" />
-        <Map s="pH_fasted" id="257" />
-        <Map s="..|Inverse rate of inflow of liquid into stomach" id="258" />
-        <Map s="StomachInflowTime" id="259" />
-        <Map s="T1|Drug|Compound type 2" id="260" />
-        <Map s="CT2" id="261" />
-        <Map s="T1|Drug|CT_NEUTRAL" id="262" />
-        <Map s="CT_NEUTRAL" id="263" />
-        <Map s="T1|Drug|pKa value 2" id="264" />
-        <Map s="pKa_2" id="265" />
-        <Map s="..|..|pH" id="266" />
-        <Map s="pH" id="267" />
-        <Map s="T1|Drug|Compound type 1" id="268" />
-        <Map s="CT1" id="269" />
-        <Map s="T1|Drug|pKa value 1" id="270" />
-        <Map s="pKa_1" id="271" />
-        <Map s="T1|Drug|Compound type 0" id="272" />
-        <Map s="CT0" id="273" />
-        <Map s="T1|Drug|pKa value 0" id="274" />
-        <Map s="pKa_0" id="275" />
-        <Map s="..|pKa_pH_WS_lum_F1" id="276" />
-        <Map s="F1" id="277" />
-        <Map s="..|pKa_pH_WS_lum_F2" id="278" />
-        <Map s="F2" id="279" />
-        <Map s="..|pKa_pH_WS_lum_F3" id="280" />
-        <Map s="F3" id="281" />
-        <Map s="..|pKa_pH_WS_lum_K1" id="282" />
-        <Map s="K1" id="283" />
-        <Map s="..|pKa_pH_WS_lum_K2" id="284" />
-        <Map s="K2" id="285" />
-        <Map s="..|pKa_pH_WS_lum_K3" id="286" />
-        <Map s="K3" id="287" />
-        <Map s="..|pKa_pH_WS_lum_K4" id="288" />
-        <Map s="K4" id="289" />
-        <Map s="..|pKa_pH_WS_lum_K5" id="290" />
-        <Map s="K5" id="291" />
-        <Map s="..|pKa_pH_WS_lum_K6" id="292" />
-        <Map s="K6" id="293" />
-        <Map s="..|pKa_pH_WS_lum_K7" id="294" />
-        <Map s="K7" id="295" />
-        <Map s="..|pKa_pH_WS_lum_K8" id="296" />
-        <Map s="K8" id="297" />
-        <Map s="T1|Drug|Solubility gain per charge" id="298" />
-        <Map s="base" id="299" />
-        <Map s="..|Solubility_pKa_pH_Factor" id="300" />
-        <Map s="Solubility_pKa_pH_Factor" id="301" />
-        <Map s="T1|Drug|Solubility at reference pH" id="302" />
-        <Map s="Solubility" id="303" />
-        <Map s="Concentration" id="304" />
-        <Map s="T1|Drug|Solubility_pKa_pH_Factor" id="305" />
-        <Map s="Solubility_pKa_REFpH_Factor" id="306" />
-        <Map s="..|..|Liquid" id="307" />
-        <Map s="..|..|..|Height" id="308" />
-        <Map s="..|r2_p0" id="309" />
-        <Map s="r2_p0" id="310" />
-        <Map s="..|r2_p1" id="311" />
-        <Map s="r2_p1" id="312" />
-        <Map s="..|Intestinal transit rate" id="313" />
-        <Map s="LuminalVelocity" id="314" />
-        <Map s="T1|Organism|SmallIntestine|Small intestinal transit time factor" id="315" />
-        <Map s="SITT_fact" id="316" />
-        <Map s="..|L_p0" id="317" />
-        <Map s="L_p0" id="318" />
-        <Map s="..|L_p1" id="319" />
-        <Map s="L_p1" id="320" />
-        <Map s="..|Absorption of liquid" id="321" />
-        <Map s="Outflow" id="322" />
-        <Map s="LT_duo" id="323" />
-        <Map s="..|..|Stomach|Liquid transfer rate" id="324" />
-        <Map s="..|..|UpperJejunum|FillLevelFlag" id="325" />
-        <Map s="..|r1_p0" id="326" />
-        <Map s="r1_p0" id="327" />
-        <Map s="..|r1_p1" id="328" />
-        <Map s="r1_p1" id="329" />
-        <Map s="..|Thickness_p1" id="330" />
-        <Map s="Thickness_p1" id="331" />
-        <Map s="..|Thickness_p2" id="332" />
-        <Map s="Thickness_p2" id="333" />
-        <Map s="..|Thickness_p3" id="334" />
-        <Map s="Thickness_p3" id="335" />
-        <Map s="InversedLength" id="336" />
-        <Map s="alpha" id="337" />
-        <Map s="k" id="338" />
-        <Map s="inflow" id="339" />
-        <Map s="..|..|Stomach|Fractional steady state fill level" id="340" />
-        <Map s="alpha_p" id="341" />
-        <Map s="..|..|Stomach|Intestinal transit rate (absolute)" id="342" />
-        <Map s="k_p" id="343" />
-        <Map s="..|..|Stomach|Volume" id="344" />
-        <Map s="V_p" id="345" />
-        <Map s="T1|Neighborhoods|Lumen_duo_Duodenum_pls|Drug|Drug absorption rate (lumen to mucosa)" id="346" />
-        <Map s="DA_para_duo" id="347" />
-        <Map s="T1|Neighborhoods|Lumen_duo_Duodenum_cell|Drug|Drug absorption rate (lumen to mucosa)" id="348" />
-        <Map s="DA_trans_duo" id="349" />
-        <Map s="..|Oral mass absorbed segment" id="350" />
-        <Map s="MassAbsorbed" id="351" />
-        <Map s="OralDrugMass" id="352" />
-        <Map s="..|..|Duodenum|Fractional steady state fill level" id="353" />
-        <Map s="..|..|Duodenum|Intestinal transit rate (absolute)" id="354" />
-        <Map s="..|..|Duodenum|Volume" id="355" />
-        <Map s="..|..|LowerJejunum|FillLevelFlag" id="356" />
-        <Map s="LT_uje" id="357" />
-        <Map s="..|..|Duodenum|Liquid transfer rate" id="358" />
-        <Map s="T1|Neighborhoods|Lumen_uje_UpperJejunum_pls|Drug|Drug absorption rate (lumen to mucosa)" id="359" />
-        <Map s="DA_para_uje" id="360" />
-        <Map s="T1|Neighborhoods|Lumen_uje_UpperJejunum_cell|Drug|Drug absorption rate (lumen to mucosa)" id="361" />
-        <Map s="DA_trans_uje" id="362" />
-        <Map s="..|..|UpperJejunum|Fractional steady state fill level" id="363" />
-        <Map s="..|..|UpperJejunum|Intestinal transit rate (absolute)" id="364" />
-        <Map s="..|..|UpperJejunum|Volume" id="365" />
-        <Map s="LT_lje" id="366" />
-        <Map s="..|..|UpperJejunum|Liquid transfer rate" id="367" />
-        <Map s="..|..|UpperIleum|FillLevelFlag" id="368" />
-        <Map s="T1|Neighborhoods|Lumen_lje_LowerJejunum_pls|Drug|Drug absorption rate (lumen to mucosa)" id="369" />
-        <Map s="DA_para_lje" id="370" />
-        <Map s="T1|Neighborhoods|Lumen_lje_LowerJejunum_cell|Drug|Drug absorption rate (lumen to mucosa)" id="371" />
-        <Map s="DA_trans_lje" id="372" />
-        <Map s="..|..|LowerJejunum|Fractional steady state fill level" id="373" />
-        <Map s="..|..|LowerJejunum|Intestinal transit rate (absolute)" id="374" />
-        <Map s="..|..|LowerJejunum|Volume" id="375" />
-        <Map s="LT_uil" id="376" />
-        <Map s="..|..|LowerJejunum|Liquid transfer rate" id="377" />
-        <Map s="..|..|LowerIleum|FillLevelFlag" id="378" />
-        <Map s="T1|Neighborhoods|Lumen_uil_UpperIleum_pls|Drug|Drug absorption rate (lumen to mucosa)" id="379" />
-        <Map s="DA_para_uil" id="380" />
-        <Map s="T1|Neighborhoods|Lumen_uil_UpperIleum_cell|Drug|Drug absorption rate (lumen to mucosa)" id="381" />
-        <Map s="DA_trans_uil" id="382" />
-        <Map s="..|..|Caecum|FillLevelFlag" id="383" />
-        <Map s="LT_lil" id="384" />
-        <Map s="..|..|UpperIleum|Liquid transfer rate" id="385" />
-        <Map s="..|..|UpperIleum|Fractional steady state fill level" id="386" />
-        <Map s="..|..|UpperIleum|Intestinal transit rate (absolute)" id="387" />
-        <Map s="..|..|UpperIleum|Volume" id="388" />
-        <Map s="T1|Neighborhoods|Lumen_lil_LowerIleum_pls|Drug|Drug absorption rate (lumen to mucosa)" id="389" />
-        <Map s="DA_para_lil" id="390" />
-        <Map s="T1|Neighborhoods|Lumen_lil_LowerIleum_cell|Drug|Drug absorption rate (lumen to mucosa)" id="391" />
-        <Map s="DA_trans_lil" id="392" />
-        <Map s="..|..|LowerIleum|Fractional steady state fill level" id="393" />
-        <Map s="..|..|LowerIleum|Intestinal transit rate (absolute)" id="394" />
-        <Map s="..|..|LowerIleum|Volume" id="395" />
-        <Map s="T1|Organism|LargeIntestine|Large intestinal transit time factor" id="396" />
-        <Map s="LITT_fact" id="397" />
-        <Map s="LT_cae" id="398" />
-        <Map s="..|..|LowerIleum|Liquid transfer rate" id="399" />
-        <Map s="..|..|ColonAscendens|FillLevelFlag" id="400" />
-        <Map s="T1|Neighborhoods|Lumen_cae_Caecum_pls|Drug|Drug absorption rate (lumen to mucosa)" id="401" />
-        <Map s="DA_para_cae" id="402" />
-        <Map s="T1|Neighborhoods|Lumen_cae_Caecum_cell|Drug|Drug absorption rate (lumen to mucosa)" id="403" />
-        <Map s="DA_trans_cae" id="404" />
-        <Map s="..|..|Caecum|Fractional steady state fill level" id="405" />
-        <Map s="..|..|Caecum|Intestinal transit rate (absolute)" id="406" />
-        <Map s="..|..|Caecum|Volume" id="407" />
-        <Map s="LT_colasc" id="408" />
-        <Map s="..|..|Caecum|Liquid transfer rate" id="409" />
-        <Map s="..|..|ColonTransversum|FillLevelFlag" id="410" />
-        <Map s="T1|Neighborhoods|Lumen_colasc_ColonAscendens_pls|Drug|Drug absorption rate (lumen to mucosa)" id="411" />
-        <Map s="DA_para_colasc" id="412" />
-        <Map s="T1|Neighborhoods|Lumen_colasc_ColonAscendens_cell|Drug|Drug absorption rate (lumen to mucosa)" id="413" />
-        <Map s="DA_trans_colasc" id="414" />
-        <Map s="..|..|ColonAscendens|Fractional steady state fill level" id="415" />
-        <Map s="..|..|ColonAscendens|Intestinal transit rate (absolute)" id="416" />
-        <Map s="..|..|ColonAscendens|Volume" id="417" />
-        <Map s="LT_coltrans" id="418" />
-        <Map s="..|..|ColonAscendens|Liquid transfer rate" id="419" />
-        <Map s="..|..|ColonDescendens|FillLevelFlag" id="420" />
-        <Map s="T1|Neighborhoods|Lumen_coltrans_ColonTransversum_pls|Drug|Drug absorption rate (lumen to mucosa)" id="421" />
-        <Map s="DA_para_coltrans" id="422" />
-        <Map s="T1|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|Drug|Drug absorption rate (lumen to mucosa)" id="423" />
-        <Map s="DA_trans_coltrans" id="424" />
-        <Map s="LT_coldesc" id="425" />
-        <Map s="..|..|ColonTransversum|Liquid transfer rate" id="426" />
-        <Map s="..|..|ColonSigmoid|FillLevelFlag" id="427" />
-        <Map s="..|..|ColonTransversum|Fractional steady state fill level" id="428" />
-        <Map s="..|..|ColonTransversum|Intestinal transit rate (absolute)" id="429" />
-        <Map s="..|..|ColonTransversum|Volume" id="430" />
-        <Map s="T1|Neighborhoods|Lumen_coldesc_ColonDescendens_pls|Drug|Drug absorption rate (lumen to mucosa)" id="431" />
-        <Map s="DA_para_coldesc" id="432" />
-        <Map s="T1|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|Drug|Drug absorption rate (lumen to mucosa)" id="433" />
-        <Map s="DA_trans_coldesc" id="434" />
-        <Map s="..|..|ColonDescendens|Fractional steady state fill level" id="435" />
-        <Map s="..|..|ColonDescendens|Intestinal transit rate (absolute)" id="436" />
-        <Map s="..|..|ColonDescendens|Volume" id="437" />
-        <Map s="LT_colsigm" id="438" />
-        <Map s="..|..|ColonDescendens|Liquid transfer rate" id="439" />
-        <Map s="..|..|Rectum|FillLevelFlag" id="440" />
-        <Map s="T1|Neighborhoods|Lumen_colsigm_ColonSigmoid_pls|Drug|Drug absorption rate (lumen to mucosa)" id="441" />
-        <Map s="DA_para_colsigm" id="442" />
-        <Map s="T1|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|Drug|Drug absorption rate (lumen to mucosa)" id="443" />
-        <Map s="DA_trans_colsigm" id="444" />
-        <Map s="..|..|ColonSigmoid|Fractional steady state fill level" id="445" />
-        <Map s="..|..|ColonSigmoid|Intestinal transit rate (absolute)" id="446" />
-        <Map s="..|..|ColonSigmoid|Volume" id="447" />
-        <Map s="LT_rect" id="448" />
-        <Map s="..|..|ColonSigmoid|Liquid transfer rate" id="449" />
-        <Map s="T1|Neighborhoods|Lumen_rect_Rectum_pls|Drug|Drug absorption rate (lumen to mucosa)" id="450" />
-        <Map s="DA_para_rect" id="451" />
-        <Map s="T1|Neighborhoods|Lumen_rect_Rectum_cell|Drug|Drug absorption rate (lumen to mucosa)" id="452" />
-        <Map s="DA_trans_rect" id="453" />
-        <Map s="..|..|Rectum|Liquid transfer rate" id="454" />
-        <Map s="LT_rec" id="455" />
-        <Map s="T1|Organism|Lumen|Caecum|Drug" id="456" />
-        <Map s="M_cae" id="457" />
-        <Map s="T1|Organism|Lumen|ColonAscendens|Drug" id="458" />
-        <Map s="M_colasc" id="459" />
-        <Map s="T1|Organism|Lumen|ColonDescendens|Drug" id="460" />
-        <Map s="M_coldesc" id="461" />
-        <Map s="T1|Organism|Lumen|ColonSigmoid|Drug" id="462" />
-        <Map s="M_colsigm" id="463" />
-        <Map s="T1|Organism|Lumen|ColonTransversum|Drug" id="464" />
-        <Map s="M_coltrans" id="465" />
-        <Map s="T1|Organism|Lumen|Duodenum|Drug" id="466" />
-        <Map s="M_duo" id="467" />
-        <Map s="T1|Organism|Lumen|Feces|Drug" id="468" />
-        <Map s="M_fec" id="469" />
-        <Map s="T1|Organism|Lumen|LowerIleum|Drug" id="470" />
-        <Map s="M_lil" id="471" />
-        <Map s="T1|Organism|Lumen|LowerJejunum|Drug" id="472" />
-        <Map s="M_lje" id="473" />
-        <Map s="T1|Organism|Lumen|Rectum|Drug" id="474" />
-        <Map s="M_rect" id="475" />
-        <Map s="M_sto" id="476" />
-        <Map s="T1|Organism|Lumen|UpperIleum|Drug" id="477" />
-        <Map s="M_uil" id="478" />
-        <Map s="T1|Organism|Lumen|UpperJejunum|Drug" id="479" />
-        <Map s="M_uje" id="480" />
-        <Map s="T1|Neighborhoods|Lumen_sto_Lumen_duo|Drug|Oral mass absorbed" id="481" />
-        <Map s="Mabs_Mucosa" id="482" />
-        <Map s="TotalOralDrugMass" id="483" />
-        <Map s="T1|Neighborhoods|Stomach_pls_Stomach_int|Surface area (plasma/interstitial)" id="484" />
-        <Map s="T1|Neighborhoods|Stomach_int_Stomach_cell|Drug|Partition coefficient (interstitial/water)" id="485" />
-        <Map s="T1|Neighborhoods|Stomach_int_Stomach_cell|Drug|Partition coefficient (intracellular/water)" id="486" />
-        <Map s="..|Colon arrival time" id="487" />
-        <Map s="Colon_Arrival_Time" id="488" />
-        <Map s="..|Colon_Arrival_Time_Intercept" id="489" />
-        <Map s="Colon_Arrival_Time_Intercept" id="490" />
-        <Map s="..|Colon_Arrival_Time_Slope" id="491" />
-        <Map s="Colon_Arrival_Time_Slope" id="492" />
-        <Map s="..|Colon_Arrival_Time_Slope_a0" id="493" />
-        <Map s="a0" id="494" />
-        <Map s="..|Colon_Arrival_Time_Slope_a1" id="495" />
-        <Map s="a1" id="496" />
-        <Map s="..|Colon_Arrival_Time_Slope_a2" id="497" />
-        <Map s="a2" id="498" />
-        <Map s="T1|Organism|Lumen|Stomach|Gastric emptying time" id="499" />
-        <Map s="..|Colon_Arrival_Time_Intercept_a0" id="500" />
-        <Map s="..|Colon_Arrival_Time_Intercept_a1" id="501" />
-        <Map s="..|Lymph flow rate (incl. mucosa)" id="502" />
-        <Map s="Q_lymph_incl_Mucosa" id="503" />
-        <Map s="..|Mucosa|Duodenum|Lymph flow rate" id="504" />
-        <Map s="Q_lymph_duo" id="505" />
-        <Map s="..|Mucosa|LowerIleum|Lymph flow rate" id="506" />
-        <Map s="Q_lymph_lil" id="507" />
-        <Map s="..|Mucosa|LowerJejunum|Lymph flow rate" id="508" />
-        <Map s="Q_lymph_lje" id="509" />
-        <Map s="..|Mucosa|UpperIleum|Lymph flow rate" id="510" />
-        <Map s="Q_lymph_uil" id="511" />
-        <Map s="..|Mucosa|UpperJejunum|Lymph flow rate" id="512" />
-        <Map s="Q_lymph_uje" id="513" />
-        <Map s="T1|Neighborhoods|SmallIntestine_pls_SmallIntestine_int|Surface area (plasma/interstitial)" id="514" />
-        <Map s="..|Fluid recirculation flow rate (incl. mucosa)" id="515" />
-        <Map s="J_iso_incl_Mucosa" id="516" />
-        <Map s="..|Mucosa|Duodenum|Fluid recirculation flow rate" id="517" />
-        <Map s="J_iso_duo" id="518" />
-        <Map s="..|Mucosa|LowerIleum|Fluid recirculation flow rate" id="519" />
-        <Map s="J_iso_lil" id="520" />
-        <Map s="..|Mucosa|LowerJejunum|Fluid recirculation flow rate" id="521" />
-        <Map s="J_iso_lje" id="522" />
-        <Map s="..|Mucosa|UpperIleum|Fluid recirculation flow rate" id="523" />
-        <Map s="J_iso_uil" id="524" />
-        <Map s="..|Mucosa|UpperJejunum|Fluid recirculation flow rate" id="525" />
-        <Map s="J_iso_uje" id="526" />
-        <Map s="..|Mucosa|Duodenum|Volume" id="527" />
-        <Map s="V_duo" id="528" />
-        <Map s="..|Mucosa|LowerIleum|Volume" id="529" />
-        <Map s="V_lil" id="530" />
-        <Map s="..|Mucosa|LowerJejunum|Volume" id="531" />
-        <Map s="V_lje" id="532" />
-        <Map s="..|Mucosa|UpperIleum|Volume" id="533" />
-        <Map s="V_uil" id="534" />
-        <Map s="..|Mucosa|UpperJejunum|Volume" id="535" />
-        <Map s="V_uje" id="536" />
-        <Map s="..|..|Volume (mucosa)" id="537" />
-        <Map s="V_Mucosa" id="538" />
-        <Map s="T1|Neighborhoods|SmallIntestine_int_SmallIntestine_cell|Drug|Partition coefficient (interstitial/water)" id="539" />
-        <Map s="T1|Neighborhoods|SmallIntestine_int_SmallIntestine_cell|Drug|Partition coefficient (intracellular/water)" id="540" />
-        <Map s="..|Fraction mucosa" id="541" />
-        <Map s="fractionMucosa" id="542" />
-        <Map s="..|..|..|..|Lumen|Duodenum|Volume (gut wall)" id="543" />
-        <Map s="V_GutWall" id="544" />
-        <Map s="..|..|..|Fluid recirculation flow rate (incl. mucosa)" id="545" />
-        <Map s="J_iso_intestine" id="546" />
-        <Map s="..|..|..|Volume" id="547" />
-        <Map s="V_intestine" id="548" />
-        <Map s="V_seg" id="549" />
-        <Map s="..|..|..|Lymph flow rate (incl. mucosa)" id="550" />
-        <Map s="Q_lymph_intestine" id="551" />
-        <Map s="T1|Neighborhoods|Duodenum_pls_Duodenum_int|Surface area (plasma/interstitial)" id="552" />
-        <Map s="..|..|..|Blood flow rate" id="553" />
-        <Map s="Q" id="554" />
-        <Map s="..|Fraction of regional blood flow rate" id="555" />
-        <Map s="regionalFractQ" id="556" />
-        <Map s="..|..|..|Mucosa blood flow fraction" id="557" />
-        <Map s="fractQ" id="558" />
-        <Map s="T1|Neighborhoods|Duodenum_int_Duodenum_cell|Drug|Partition coefficient (interstitial/water)" id="559" />
-        <Map s="T1|Neighborhoods|Duodenum_int_Duodenum_cell|Drug|Partition coefficient (intracellular/water)" id="560" />
-        <Map s="..|..|..|..|Lumen|UpperJejunum|Volume (gut wall)" id="561" />
-        <Map s="T1|Neighborhoods|UpperJejunum_pls_UpperJejunum_int|Surface area (plasma/interstitial)" id="562" />
-        <Map s="T1|Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Drug|Partition coefficient (interstitial/water)" id="563" />
-        <Map s="T1|Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Drug|Partition coefficient (intracellular/water)" id="564" />
-        <Map s="..|..|..|..|Lumen|LowerJejunum|Volume (gut wall)" id="565" />
-        <Map s="T1|Neighborhoods|LowerJejunum_pls_LowerJejunum_int|Surface area (plasma/interstitial)" id="566" />
-        <Map s="T1|Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Drug|Partition coefficient (interstitial/water)" id="567" />
-        <Map s="T1|Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Drug|Partition coefficient (intracellular/water)" id="568" />
-        <Map s="..|..|..|..|Lumen|UpperIleum|Volume (gut wall)" id="569" />
-        <Map s="T1|Neighborhoods|UpperIleum_pls_UpperIleum_int|Surface area (plasma/interstitial)" id="570" />
-        <Map s="T1|Neighborhoods|UpperIleum_int_UpperIleum_cell|Drug|Partition coefficient (interstitial/water)" id="571" />
-        <Map s="T1|Neighborhoods|UpperIleum_int_UpperIleum_cell|Drug|Partition coefficient (intracellular/water)" id="572" />
-        <Map s="..|..|..|..|Lumen|LowerIleum|Volume (gut wall)" id="573" />
-        <Map s="T1|Neighborhoods|LowerIleum_pls_LowerIleum_int|Surface area (plasma/interstitial)" id="574" />
-        <Map s="T1|Neighborhoods|LowerIleum_int_LowerIleum_cell|Drug|Partition coefficient (interstitial/water)" id="575" />
-        <Map s="T1|Neighborhoods|LowerIleum_int_LowerIleum_cell|Drug|Partition coefficient (intracellular/water)" id="576" />
-        <Map s="T1|Organism|SmallIntestine|Interstitial|Volume" id="577" />
-        <Map s="V_int" id="578" />
-        <Map s="T1|Organism|SmallIntestine|Mucosa|Duodenum|Interstitial|Volume" id="579" />
-        <Map s="V_int_duo" id="580" />
-        <Map s="T1|Organism|SmallIntestine|Mucosa|LowerIleum|Interstitial|Volume" id="581" />
-        <Map s="V_int_lil" id="582" />
-        <Map s="T1|Organism|SmallIntestine|Mucosa|LowerJejunum|Interstitial|Volume" id="583" />
-        <Map s="V_int_lje" id="584" />
-        <Map s="T1|Organism|SmallIntestine|Mucosa|UpperIleum|Interstitial|Volume" id="585" />
-        <Map s="V_int_uil" id="586" />
-        <Map s="T1|Organism|SmallIntestine|Mucosa|UpperJejunum|Interstitial|Volume" id="587" />
-        <Map s="V_int_uje" id="588" />
-        <Map s="T1|Organism|SmallIntestine|Intracellular|Volume" id="589" />
-        <Map s="V_cell" id="590" />
-        <Map s="T1|Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|Volume" id="591" />
-        <Map s="V_cell_duo" id="592" />
-        <Map s="T1|Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|Volume" id="593" />
-        <Map s="V_cell_lil" id="594" />
-        <Map s="T1|Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|Volume" id="595" />
-        <Map s="V_cell_lje" id="596" />
-        <Map s="T1|Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|Volume" id="597" />
-        <Map s="V_cell_uil" id="598" />
-        <Map s="T1|Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|Volume" id="599" />
-        <Map s="V_cell_uje" id="600" />
-        <Map s="T1|Organism|SmallIntestine|Intracellular|Drug" id="601" />
-        <Map s="M_cell" id="602" />
-        <Map s="T1|Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|Drug" id="603" />
-        <Map s="M_cell_duo" id="604" />
-        <Map s="T1|Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|Drug" id="605" />
-        <Map s="M_cell_lil" id="606" />
-        <Map s="T1|Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|Drug" id="607" />
-        <Map s="M_cell_lje" id="608" />
-        <Map s="T1|Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|Drug" id="609" />
-        <Map s="M_cell_uil" id="610" />
-        <Map s="T1|Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|Drug" id="611" />
-        <Map s="M_cell_uje" id="612" />
-        <Map s="T1|Organism|SmallIntestine|Interstitial|Drug" id="613" />
-        <Map s="M_int" id="614" />
-        <Map s="T1|Organism|SmallIntestine|Mucosa|Duodenum|Interstitial|Drug" id="615" />
-        <Map s="M_int_duo" id="616" />
-        <Map s="T1|Organism|SmallIntestine|Mucosa|LowerIleum|Interstitial|Drug" id="617" />
-        <Map s="M_int_lil" id="618" />
-        <Map s="T1|Organism|SmallIntestine|Mucosa|LowerJejunum|Interstitial|Drug" id="619" />
-        <Map s="M_int_lje" id="620" />
-        <Map s="T1|Organism|SmallIntestine|Mucosa|UpperIleum|Interstitial|Drug" id="621" />
-        <Map s="M_int_uil" id="622" />
-        <Map s="T1|Organism|SmallIntestine|Mucosa|UpperJejunum|Interstitial|Drug" id="623" />
-        <Map s="M_int_uje" id="624" />
-        <Map s="..|Excretion time" id="625" />
-        <Map s="Excretion_Time" id="626" />
-        <Map s="..|Excretion_Time_k0" id="627" />
-        <Map s="Excretion_Time_k0" id="628" />
-        <Map s="..|Excretion_Time_k1" id="629" />
-        <Map s="Excretion_Time_k1" id="630" />
-        <Map s="..|Excretion_Time_k2" id="631" />
-        <Map s="Excretion_Time_k2" id="632" />
-        <Map s="T1|Organism|SmallIntestine|Colon arrival time" id="633" />
-        <Map s="..|Mucosa|Caecum|Volume" id="634" />
-        <Map s="V_cae" id="635" />
-        <Map s="..|Mucosa|ColonAscendens|Volume" id="636" />
-        <Map s="V_ca" id="637" />
-        <Map s="..|Mucosa|ColonDescendens|Volume" id="638" />
-        <Map s="V_cd" id="639" />
-        <Map s="..|Mucosa|ColonSigmoid|Volume" id="640" />
-        <Map s="V_cs" id="641" />
-        <Map s="..|Mucosa|ColonTransversum|Volume" id="642" />
-        <Map s="V_ct" id="643" />
-        <Map s="..|Mucosa|Rectum|Volume" id="644" />
-        <Map s="V_rec" id="645" />
-        <Map s="T1|Neighborhoods|LargeIntestine_pls_LargeIntestine_int|Surface area (plasma/interstitial)" id="646" />
-        <Map s="..|Mucosa|Caecum|Lymph flow rate" id="647" />
-        <Map s="Q_lymph_cae" id="648" />
-        <Map s="..|Mucosa|ColonAscendens|Lymph flow rate" id="649" />
-        <Map s="Q_lymph_colasc" id="650" />
-        <Map s="..|Mucosa|ColonDescendens|Lymph flow rate" id="651" />
-        <Map s="Q_lymph_coldesc" id="652" />
-        <Map s="..|Mucosa|ColonSigmoid|Lymph flow rate" id="653" />
-        <Map s="Q_lymph_colsigm" id="654" />
-        <Map s="..|Mucosa|ColonTransversum|Lymph flow rate" id="655" />
-        <Map s="Q_lymph_coltrans" id="656" />
-        <Map s="..|Mucosa|Rectum|Lymph flow rate" id="657" />
-        <Map s="Q_lymph_rect" id="658" />
-        <Map s="..|Mucosa|Caecum|Fluid recirculation flow rate" id="659" />
-        <Map s="J_iso_cae" id="660" />
-        <Map s="..|Mucosa|ColonAscendens|Fluid recirculation flow rate" id="661" />
-        <Map s="J_iso_colasc" id="662" />
-        <Map s="..|Mucosa|ColonDescendens|Fluid recirculation flow rate" id="663" />
-        <Map s="J_iso_coldesc" id="664" />
-        <Map s="..|Mucosa|ColonSigmoid|Fluid recirculation flow rate" id="665" />
-        <Map s="J_iso_colsigm" id="666" />
-        <Map s="..|Mucosa|ColonTransversum|Fluid recirculation flow rate" id="667" />
-        <Map s="J_iso_coltrans" id="668" />
-        <Map s="..|Mucosa|Rectum|Fluid recirculation flow rate" id="669" />
-        <Map s="J_iso_rect" id="670" />
-        <Map s="T1|Neighborhoods|LargeIntestine_int_LargeIntestine_cell|Drug|Partition coefficient (interstitial/water)" id="671" />
-        <Map s="T1|Neighborhoods|LargeIntestine_int_LargeIntestine_cell|Drug|Partition coefficient (intracellular/water)" id="672" />
-        <Map s="..|..|..|..|Lumen|Caecum|Volume (gut wall)" id="673" />
-        <Map s="T1|Neighborhoods|Caecum_pls_Caecum_int|Surface area (plasma/interstitial)" id="674" />
-        <Map s="T1|Neighborhoods|Caecum_int_Caecum_cell|Drug|Partition coefficient (interstitial/water)" id="675" />
-        <Map s="T1|Neighborhoods|Caecum_int_Caecum_cell|Drug|Partition coefficient (intracellular/water)" id="676" />
-        <Map s="..|..|..|..|Lumen|ColonAscendens|Volume (gut wall)" id="677" />
-        <Map s="T1|Neighborhoods|ColonAscendens_pls_ColonAscendens_int|Surface area (plasma/interstitial)" id="678" />
-        <Map s="T1|Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Drug|Partition coefficient (interstitial/water)" id="679" />
-        <Map s="T1|Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Drug|Partition coefficient (intracellular/water)" id="680" />
-        <Map s="..|..|..|..|Lumen|ColonTransversum|Volume (gut wall)" id="681" />
-        <Map s="T1|Neighborhoods|ColonTransversum_pls_ColonTransversum_int|Surface area (plasma/interstitial)" id="682" />
-        <Map s="T1|Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Drug|Partition coefficient (interstitial/water)" id="683" />
-        <Map s="T1|Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Drug|Partition coefficient (intracellular/water)" id="684" />
-        <Map s="..|..|..|..|Lumen|ColonDescendens|Volume (gut wall)" id="685" />
-        <Map s="T1|Neighborhoods|ColonDescendens_pls_ColonDescendens_int|Surface area (plasma/interstitial)" id="686" />
-        <Map s="T1|Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Drug|Partition coefficient (interstitial/water)" id="687" />
-        <Map s="T1|Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Drug|Partition coefficient (intracellular/water)" id="688" />
-        <Map s="..|..|..|..|Lumen|ColonSigmoid|Volume (gut wall)" id="689" />
-        <Map s="T1|Neighborhoods|ColonSigmoid_pls_ColonSigmoid_int|Surface area (plasma/interstitial)" id="690" />
-        <Map s="T1|Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Drug|Partition coefficient (interstitial/water)" id="691" />
-        <Map s="T1|Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Drug|Partition coefficient (intracellular/water)" id="692" />
-        <Map s="..|..|..|..|Lumen|Rectum|Volume (gut wall)" id="693" />
-        <Map s="T1|Neighborhoods|Rectum_pls_Rectum_int|Surface area (plasma/interstitial)" id="694" />
-        <Map s="T1|Neighborhoods|Rectum_int_Rectum_cell|Drug|Partition coefficient (interstitial/water)" id="695" />
-        <Map s="T1|Neighborhoods|Rectum_int_Rectum_cell|Drug|Partition coefficient (intracellular/water)" id="696" />
-        <Map s="T1|Organism|LargeIntestine|Interstitial|Volume" id="697" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|Caecum|Interstitial|Volume" id="698" />
-        <Map s="V_int_cae" id="699" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|ColonAscendens|Interstitial|Volume" id="700" />
-        <Map s="V_int_colasc" id="701" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|ColonDescendens|Interstitial|Volume" id="702" />
-        <Map s="V_int_coldesc" id="703" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|ColonSigmoid|Interstitial|Volume" id="704" />
-        <Map s="V_int_colsigm" id="705" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|ColonTransversum|Interstitial|Volume" id="706" />
-        <Map s="V_int_coltrans" id="707" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|Rectum|Interstitial|Volume" id="708" />
-        <Map s="V_int_rect" id="709" />
-        <Map s="T1|Organism|LargeIntestine|Intracellular|Volume" id="710" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|Caecum|Intracellular|Volume" id="711" />
-        <Map s="V_cell_cae" id="712" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|Volume" id="713" />
-        <Map s="V_cell_colasc" id="714" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|Volume" id="715" />
-        <Map s="V_cell_coldesc" id="716" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|Volume" id="717" />
-        <Map s="V_cell_colsigm" id="718" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|Volume" id="719" />
-        <Map s="V_cell_coltrans" id="720" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|Rectum|Intracellular|Volume" id="721" />
-        <Map s="V_cell_rect" id="722" />
-        <Map s="T1|Organism|LargeIntestine|Intracellular|Drug" id="723" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|Caecum|Intracellular|Drug" id="724" />
-        <Map s="M_cell_cae" id="725" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|Drug" id="726" />
-        <Map s="M_cell_colasc" id="727" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|Drug" id="728" />
-        <Map s="M_cell_coldesc" id="729" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|Drug" id="730" />
-        <Map s="M_cell_colsigm" id="731" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|Drug" id="732" />
-        <Map s="M_cell_coltrans" id="733" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|Rectum|Intracellular|Drug" id="734" />
-        <Map s="M_cell_rect" id="735" />
-        <Map s="T1|Organism|LargeIntestine|Interstitial|Drug" id="736" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|Caecum|Interstitial|Drug" id="737" />
-        <Map s="M_int_cae" id="738" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|ColonAscendens|Interstitial|Drug" id="739" />
-        <Map s="M_int_colasc" id="740" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|ColonDescendens|Interstitial|Drug" id="741" />
-        <Map s="M_int_coldesc" id="742" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|ColonSigmoid|Interstitial|Drug" id="743" />
-        <Map s="M_int_colsigm" id="744" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|ColonTransversum|Interstitial|Drug" id="745" />
-        <Map s="M_int_coltrans" id="746" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|Rectum|Interstitial|Drug" id="747" />
-        <Map s="M_int_rect" id="748" />
-        <Map s="T1|Neighborhoods|Liver_pls_Liver_int|Surface area (plasma/interstitial)" id="749" />
-        <Map s="T1|Neighborhoods|Liver_int_Liver_cell|Drug|Partition coefficient (interstitial/water)" id="750" />
-        <Map s="T1|Neighborhoods|Liver_int_Liver_cell|Drug|Partition coefficient (intracellular/water)" id="751" />
-        <Map s="T1|Neighborhoods|Lung_pls_Lung_int|Surface area (plasma/interstitial)" id="752" />
-        <Map s="T1|Organism|Bone|Blood flow rate" id="753" />
-        <Map s="Q_bon" id="754" />
-        <Map s="T1|Organism|Brain|Blood flow rate" id="755" />
-        <Map s="Q_brn" id="756" />
-        <Map s="T1|Organism|Fat|Blood flow rate" id="757" />
-        <Map s="Q_fat" id="758" />
-        <Map s="T1|Organism|Gonads|Blood flow rate" id="759" />
-        <Map s="Q_tes" id="760" />
-        <Map s="T1|Organism|Heart|Blood flow rate" id="761" />
-        <Map s="Q_hrt" id="762" />
-        <Map s="T1|Organism|Kidney|Blood flow rate" id="763" />
-        <Map s="Q_kid" id="764" />
-        <Map s="T1|Organism|LargeIntestine|Blood flow rate" id="765" />
-        <Map s="Q_lin" id="766" />
-        <Map s="T1|Organism|Liver|Blood flow rate" id="767" />
-        <Map s="Q_liv" id="768" />
-        <Map s="T1|Organism|Muscle|Blood flow rate" id="769" />
-        <Map s="Q_mus" id="770" />
-        <Map s="T1|Organism|Pancreas|Blood flow rate" id="771" />
-        <Map s="Q_pan" id="772" />
-        <Map s="T1|Organism|Skin|Blood flow rate" id="773" />
-        <Map s="Q_skn" id="774" />
-        <Map s="T1|Organism|SmallIntestine|Blood flow rate" id="775" />
-        <Map s="Q_sin" id="776" />
-        <Map s="T1|Organism|Spleen|Blood flow rate" id="777" />
-        <Map s="Q_spl" id="778" />
-        <Map s="T1|Organism|Stomach|Blood flow rate" id="779" />
-        <Map s="Q_sto" id="780" />
-        <Map s="T1|Neighborhoods|Lung_int_Lung_cell|Drug|Partition coefficient (interstitial/water)" id="781" />
-        <Map s="T1|Neighborhoods|Lung_int_Lung_cell|Drug|Partition coefficient (intracellular/water)" id="782" />
-        <Map s="T1|Neighborhoods|Muscle_pls_Muscle_int|Surface area (plasma/interstitial)" id="783" />
-        <Map s="T1|Neighborhoods|Muscle_int_Muscle_cell|Drug|Partition coefficient (interstitial/water)" id="784" />
-        <Map s="T1|Neighborhoods|Muscle_int_Muscle_cell|Drug|Partition coefficient (intracellular/water)" id="785" />
-        <Map s="T1|Neighborhoods|Pancreas_pls_Pancreas_int|Surface area (plasma/interstitial)" id="786" />
-        <Map s="T1|Neighborhoods|Pancreas_int_Pancreas_cell|Drug|Partition coefficient (interstitial/water)" id="787" />
-        <Map s="T1|Neighborhoods|Pancreas_int_Pancreas_cell|Drug|Partition coefficient (intracellular/water)" id="788" />
-        <Map s="T1|Organism|LargeIntestine|Lymph flow rate (incl. mucosa)" id="789" />
-        <Map s="Q_Lymph_lin_incl_Mucosa" id="790" />
-        <Map s="T1|Organism|Pancreas|Lymph flow rate" id="791" />
-        <Map s="Q_Lymph_pan" id="792" />
-        <Map s="T1|Organism|SmallIntestine|Lymph flow rate (incl. mucosa)" id="793" />
-        <Map s="Q_Lymph_sin_incl_Mucosa" id="794" />
-        <Map s="T1|Organism|Spleen|Lymph flow rate" id="795" />
-        <Map s="Q_Lymph_spl" id="796" />
-        <Map s="T1|Organism|Stomach|Lymph flow rate" id="797" />
-        <Map s="Q_Lymph_sto" id="798" />
-        <Map s="T1|Neighborhoods|Skin_pls_Skin_int|Surface area (plasma/interstitial)" id="799" />
-        <Map s="T1|Neighborhoods|Skin_int_Skin_cell|Drug|Partition coefficient (interstitial/water)" id="800" />
-        <Map s="T1|Neighborhoods|Skin_int_Skin_cell|Drug|Partition coefficient (intracellular/water)" id="801" />
-        <Map s="T1|Neighborhoods|Spleen_pls_Spleen_int|Surface area (plasma/interstitial)" id="802" />
-        <Map s="T1|Neighborhoods|Spleen_int_Spleen_cell|Drug|Partition coefficient (interstitial/water)" id="803" />
-        <Map s="T1|Neighborhoods|Spleen_int_Spleen_cell|Drug|Partition coefficient (intracellular/water)" id="804" />
-        <Map s="T1|Organism|Saliva|Volume" id="805" />
-        <Map s="V_slv" id="806" />
-        <Map s="T1|Organism|VenousBlood|BloodCells|Drug|Concentration" id="807" />
-        <Map s="T1|Organism|VenousBlood|Plasma|Drug|Concentration" id="808" />
-        <Map s="T1|Drug|P (blood cells-&gt;plasma)" id="809" />
-        <Map s="P_rbc_pls" id="810" />
-        <Map s="Velocity" id="811" />
-        <Map s="T1|Drug|P (plasma-&gt;blood cells)" id="812" />
-        <Map s="P_pls_rbc" id="813" />
-        <Map s="T1|Neighborhoods|VenousBlood_pls_VenousBlood_bc|Surface area (blood cells/plasma)" id="814" />
-        <Map s="SA_bc" id="815" />
-        <Map s="T1|Organism|VenousBlood|Plasma|..|Volume" id="816" />
-        <Map s="T1|Organism|Surface/Volume ratio (blood cells)" id="817" />
-        <Map s="A_to_V_bc" id="818" />
-        <Map s="T1|Organism|Lung|BloodCells|..|Blood flow rate" id="819" />
-        <Map s="T1|Organism|Lung|Plasma|..|Blood flow rate" id="820" />
-        <Map s="T1|Neighborhoods|ArterialBlood_pls_ArterialBlood_bc|Surface area (blood cells/plasma)" id="821" />
-        <Map s="T1|Organism|ArterialBlood|Plasma|..|Volume" id="822" />
-        <Map s="..|P_int_cell_factor" id="823" />
-        <Map s="P_int_cell_factor" id="824" />
-        <Map s="T1|Drug|Permeability" id="825" />
-        <Map s="P" id="826" />
-        <Map s="..|P_cell_int_factor" id="827" />
-        <Map s="P_cell_int_factor" id="828" />
-        <Map s="..|P (interstitial-&gt;intracellular)" id="829" />
-        <Map s="P_int_cell" id="830" />
-        <Map s="..|..|Surface area (interstitial/intracellular)" id="831" />
-        <Map s="SA" id="832" />
-        <Map s="..|P (intracellular-&gt;interstitial)" id="833" />
-        <Map s="P_cell_int" id="834" />
-        <Map s="T1|Drug|Lipophilicity" id="835" />
-        <Map s="LogMA" id="836" />
-        <Map s="Lipophilicity" id="837" />
-        <Map s="T1|Drug|Partition coefficient (water/protein)" id="838" />
-        <Map s="KProt" id="839" />
-        <Map s="T1|Organism|Bone|Interstitial|..|Vf (lipid)" id="840" />
-        <Map s="f_lipids" id="841" />
-        <Map s="T1|Organism|Bone|Interstitial|..|Vf (protein)" id="842" />
-        <Map s="f_proteins" id="843" />
-        <Map s="T1|Organism|Bone|Interstitial|..|Vf (water)" id="844" />
-        <Map s="f_water" id="845" />
-        <Map s="..|Partition coefficient (intracellular/plasma)" id="846" />
-        <Map s="K_cell_pls" id="847" />
-        <Map s="T1|Neighborhoods|Bone_pls_Bone_int|Drug|Partition coefficient (interstitial/plasma)" id="848" />
-        <Map s="K_int_pls" id="849" />
-        <Map s="T1|Organism|Bone|Intracellular|Drug|Concentration" id="850" />
-        <Map s="T1|Organism|Bone|Interstitial|Drug|Concentration" id="851" />
-        <Map s="T1|Neighborhoods|Bone_int_Bone_cell|Drug|P*SA interstitial -&gt; intracellular" id="852" />
-        <Map s="PA_int_cell" id="853" />
-        <Map s="T1|Neighborhoods|Bone_int_Bone_cell|Drug|P*SA intracellular -&gt; interstitial" id="854" />
-        <Map s="PA_cell_int" id="855" />
-        <Map s="T1|Organism|Bone|Interstitial|..|Volume" id="856" />
-        <Map s="T1|Organism|Bone|BloodCells|..|Blood flow rate" id="857" />
-        <Map s="T1|Organism|Protein ratio (interstial/plasma)" id="858" />
-        <Map s="f_proteins_int_to_pls" id="859" />
-        <Map s="T1|Organism|Vf (water,interstitial)" id="860" />
-        <Map s="f_water_int" id="861" />
-        <Map s="T1|Organism|Vf (water,plasma)" id="862" />
-        <Map s="f_water_pls" id="863" />
-        <Map s="T1|Neighborhoods|Bone_pls_Bone_int|Drug|P (plasma&lt;-&gt;interstitial)" id="864" />
-        <Map s="P_endothelial" id="865" />
-        <Map s="T1|Organism|Bone|Plasma|..|Fraction vascular" id="866" />
-        <Map s="f_vas_org" id="867" />
-        <Map s="T1|Organism|Bone|Plasma|..|Volume" id="868" />
-        <Map s="T1|Organism|SA proportionality factor" id="869" />
-        <Map s="T1|Organism|Bone|Plasma|..|Blood flow rate" id="870" />
-        <Map s="T1|Neighborhoods|Bone_pls_Bone_bc|Surface area (blood cells/plasma)" id="871" />
-        <Map s="T1|Organism|Brain|BloodCells|Drug|Concentration" id="872" />
-        <Map s="T1|Organism|Brain|Plasma|Drug|Concentration" id="873" />
-        <Map s="T1|Neighborhoods|Brain_pls_Brain_bc|Surface area (blood cells/plasma)" id="874" />
-        <Map s="T1|Organism|Brain|Plasma|..|Fraction vascular" id="875" />
-        <Map s="T1|Organism|Brain|Plasma|..|Volume" id="876" />
-        <Map s="T1|Organism|Brain|Plasma|..|Blood flow rate" id="877" />
-        <Map s="T1|Organism|Brain|Interstitial|Drug|Concentration" id="878" />
-        <Map s="T1|Neighborhoods|Brain_pls_Brain_int|Drug|P (plasma&lt;-&gt;interstitial)" id="879" />
-        <Map s="T1|Neighborhoods|Brain_pls_Brain_int|Drug|Partition coefficient (interstitial/plasma)" id="880" />
-        <Map s="T1|Organism|Brain|BloodCells|..|Blood flow rate" id="881" />
-        <Map s="T1|Organism|Brain|Interstitial|..|Vf (lipid)" id="882" />
-        <Map s="T1|Organism|Brain|Interstitial|..|Vf (protein)" id="883" />
-        <Map s="T1|Organism|Brain|Interstitial|..|Vf (water)" id="884" />
-        <Map s="T1|Organism|Brain|Intracellular|Drug|Concentration" id="885" />
-        <Map s="T1|Neighborhoods|Brain_int_Brain_cell|Drug|P*SA interstitial -&gt; intracellular" id="886" />
-        <Map s="T1|Neighborhoods|Brain_int_Brain_cell|Drug|P*SA intracellular -&gt; interstitial" id="887" />
-        <Map s="T1|Organism|Brain|Interstitial|..|Volume" id="888" />
-        <Map s="T1|Neighborhoods|Fat_pls_Fat_bc|Surface area (blood cells/plasma)" id="889" />
-        <Map s="T1|Organism|Fat|Plasma|..|Fraction vascular" id="890" />
-        <Map s="T1|Organism|Fat|Plasma|..|Volume" id="891" />
-        <Map s="T1|Organism|Fat|BloodCells|..|Blood flow rate" id="892" />
-        <Map s="T1|Organism|Fat|Interstitial|..|Vf (lipid)" id="893" />
-        <Map s="T1|Organism|Fat|Interstitial|..|Vf (protein)" id="894" />
-        <Map s="T1|Organism|Fat|Interstitial|..|Vf (water)" id="895" />
-        <Map s="T1|Neighborhoods|Fat_pls_Fat_int|Drug|Partition coefficient (interstitial/plasma)" id="896" />
-        <Map s="T1|Organism|Fat|Intracellular|Drug|Concentration" id="897" />
-        <Map s="T1|Organism|Fat|Interstitial|Drug|Concentration" id="898" />
-        <Map s="T1|Neighborhoods|Fat_int_Fat_cell|Drug|P*SA interstitial -&gt; intracellular" id="899" />
-        <Map s="T1|Neighborhoods|Fat_int_Fat_cell|Drug|P*SA intracellular -&gt; interstitial" id="900" />
-        <Map s="T1|Organism|Fat|Interstitial|..|Volume" id="901" />
-        <Map s="T1|Neighborhoods|Fat_pls_Fat_int|Drug|P (plasma&lt;-&gt;interstitial)" id="902" />
-        <Map s="T1|Organism|Fat|Plasma|..|Blood flow rate" id="903" />
-        <Map s="T1|Organism|Gonads|BloodCells|..|Blood flow rate" id="904" />
-        <Map s="T1|Organism|Gonads|BloodCells|Drug|Concentration" id="905" />
-        <Map s="T1|Organism|Gonads|Plasma|..|Blood flow rate" id="906" />
-        <Map s="T1|Organism|Gonads|Plasma|Drug|Concentration" id="907" />
-        <Map s="T1|Organism|Gonads|Interstitial|..|Vf (lipid)" id="908" />
-        <Map s="T1|Organism|Gonads|Interstitial|..|Vf (protein)" id="909" />
-        <Map s="T1|Organism|Gonads|Interstitial|..|Vf (water)" id="910" />
-        <Map s="T1|Neighborhoods|Gonads_pls_Gonads_int|Drug|Partition coefficient (interstitial/plasma)" id="911" />
-        <Map s="T1|Organism|Gonads|Intracellular|Drug|Concentration" id="912" />
-        <Map s="T1|Organism|Gonads|Interstitial|Drug|Concentration" id="913" />
-        <Map s="T1|Neighborhoods|Gonads_int_Gonads_cell|Drug|P*SA interstitial -&gt; intracellular" id="914" />
-        <Map s="T1|Neighborhoods|Gonads_int_Gonads_cell|Drug|P*SA intracellular -&gt; interstitial" id="915" />
-        <Map s="T1|Organism|Gonads|Interstitial|..|Volume" id="916" />
-        <Map s="T1|Neighborhoods|Gonads_pls_Gonads_bc|Surface area (blood cells/plasma)" id="917" />
-        <Map s="T1|Organism|Gonads|Plasma|..|Fraction vascular" id="918" />
-        <Map s="T1|Organism|Gonads|Plasma|..|Volume" id="919" />
-        <Map s="T1|Neighborhoods|Gonads_pls_Gonads_int|Drug|P (plasma&lt;-&gt;interstitial)" id="920" />
-        <Map s="T1|Organism|Heart|BloodCells|Drug|Concentration" id="921" />
-        <Map s="T1|Organism|Heart|Plasma|Drug|Concentration" id="922" />
-        <Map s="T1|Neighborhoods|Heart_pls_Heart_bc|Surface area (blood cells/plasma)" id="923" />
-        <Map s="T1|Organism|Heart|Plasma|..|Fraction vascular" id="924" />
-        <Map s="T1|Organism|Heart|Plasma|..|Volume" id="925" />
-        <Map s="T1|Organism|Heart|Plasma|..|Blood flow rate" id="926" />
-        <Map s="T1|Organism|Heart|Interstitial|Drug|Concentration" id="927" />
-        <Map s="T1|Neighborhoods|Heart_pls_Heart_int|Drug|P (plasma&lt;-&gt;interstitial)" id="928" />
-        <Map s="T1|Neighborhoods|Heart_pls_Heart_int|Drug|Partition coefficient (interstitial/plasma)" id="929" />
-        <Map s="T1|Organism|Heart|Interstitial|..|Vf (lipid)" id="930" />
-        <Map s="T1|Organism|Heart|Interstitial|..|Vf (protein)" id="931" />
-        <Map s="T1|Organism|Heart|Interstitial|..|Vf (water)" id="932" />
-        <Map s="T1|Organism|Heart|Intracellular|Drug|Concentration" id="933" />
-        <Map s="T1|Neighborhoods|Heart_int_Heart_cell|Drug|P*SA interstitial -&gt; intracellular" id="934" />
-        <Map s="T1|Neighborhoods|Heart_int_Heart_cell|Drug|P*SA intracellular -&gt; interstitial" id="935" />
-        <Map s="T1|Organism|Heart|Interstitial|..|Volume" id="936" />
-        <Map s="T1|Organism|Heart|BloodCells|..|Blood flow rate" id="937" />
-        <Map s="T1|Organism|Kidney|BloodCells|..|Blood flow rate" id="938" />
-        <Map s="T1|Organism|Kidney|BloodCells|Drug|Concentration" id="939" />
-        <Map s="T1|Organism|Kidney|Plasma|Drug|Concentration" id="940" />
-        <Map s="T1|Neighborhoods|Kidney_pls_Kidney_bc|Surface area (blood cells/plasma)" id="941" />
-        <Map s="T1|Organism|Kidney|Plasma|..|Fraction vascular" id="942" />
-        <Map s="T1|Organism|Kidney|Plasma|..|Volume" id="943" />
-        <Map s="T1|Organism|Kidney|Interstitial|Drug|Concentration" id="944" />
-        <Map s="T1|Neighborhoods|Kidney_pls_Kidney_int|Drug|P (plasma&lt;-&gt;interstitial)" id="945" />
-        <Map s="T1|Neighborhoods|Kidney_pls_Kidney_int|Drug|Partition coefficient (interstitial/plasma)" id="946" />
-        <Map s="T1|Organism|Kidney|Plasma|..|Blood flow rate" id="947" />
-        <Map s="T1|Organism|Kidney|Interstitial|..|Vf (lipid)" id="948" />
-        <Map s="T1|Organism|Kidney|Interstitial|..|Vf (protein)" id="949" />
-        <Map s="T1|Organism|Kidney|Interstitial|..|Vf (water)" id="950" />
-        <Map s="T1|Organism|Kidney|Intracellular|Drug|Concentration" id="951" />
-        <Map s="T1|Neighborhoods|Kidney_int_Kidney_cell|Drug|P*SA interstitial -&gt; intracellular" id="952" />
-        <Map s="T1|Neighborhoods|Kidney_int_Kidney_cell|Drug|P*SA intracellular -&gt; interstitial" id="953" />
-        <Map s="T1|Organism|Kidney|Interstitial|..|Volume" id="954" />
-        <Map s="..|pKa_pH_WS_cell_F1" id="955" />
-        <Map s="..|pKa_pH_WS_cell_F2" id="956" />
-        <Map s="..|pKa_pH_WS_cell_F3" id="957" />
-        <Map s="T1|Organism|Lumen|UpperJejunum|Effective surface area enhancement factor" id="958" />
-        <Map s="AeffFactor" id="959" />
-        <Map s="T1|Organism|Lumen|UpperJejunum|Geometric surface area" id="960" />
-        <Map s="Ageom" id="961" />
-        <Map s="T1|Organism|Lumen|UpperJejunum|Liquid" id="962" />
-        <Map s="DrugLiquid" id="963" />
-        <Map s="T1|Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|Drug|Concentration" id="964" />
-        <Map s="DrugMucosa" id="965" />
-        <Map s="T1|Drug|Intestinal permeability (transcellular)" id="966" />
-        <Map s="P_int_trans" id="967" />
-        <Map s="T1|Drug|Molecular weight" id="968" />
-        <Map s="MW" id="969" />
-        <Map s="MolecularWeight" id="970" />
-        <Map s="T1|Neighborhoods|Lumen_uje_UpperJejunum_cell|Drug|P_int_trans_cell_lum_factor" id="971" />
-        <Map s="P_int_trans_cell_lum_factor" id="972" />
-        <Map s="T1|Neighborhoods|Lumen_uje_UpperJejunum_cell|Drug|P_int_trans_lum_cell_factor" id="973" />
-        <Map s="P_int_trans_lum_cell_factor" id="974" />
-        <Map s="T1|Organism|Lumen|UpperJejunum|Drug|Solubility" id="975" />
-        <Map s="T1|Organism|Lumen|UpperJejunum|..|OralApplicationsEnabled" id="976" />
-        <Map s="T1|Organism|Lumen|UpperJejunum|..|Transcellular absorption sink condition" id="977" />
-        <Map s="k_Liquid_trans" id="978" />
-        <Map s="..|pKa_pH_WS_cell_K1" id="979" />
-        <Map s="..|pKa_pH_WS_cell_K2" id="980" />
-        <Map s="..|pKa_pH_WS_cell_K3" id="981" />
-        <Map s="..|pKa_pH_WS_cell_K4" id="982" />
-        <Map s="..|pKa_pH_WS_cell_K5" id="983" />
-        <Map s="..|pKa_pH_WS_cell_K6" id="984" />
-        <Map s="..|pKa_pH_WS_cell_K7" id="985" />
-        <Map s="..|pKa_pH_WS_cell_K8" id="986" />
-        <Map s="T1|Drug|base_For_Pint_Factor" id="987" />
-        <Map s="T1|Drug|Use pH- and pKa-dependent penalty factor for charged molecule fraction" id="988" />
-        <Map s="UsePenaltyFactor" id="989" />
-        <Map s="T1|Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Drug|Partition coefficient (intracellular/plasma)" id="990" />
-        <Map s="T1|Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|pH" id="991" />
-        <Map s="T1|Organism|Lumen|UpperJejunum|pH" id="992" />
-        <Map s="DrugAbsorptionLumenToMucosaRate" id="993" />
-        <Map s="T1|Organism|SmallIntestine|Mucosa|UpperJejunum|BloodCells|Drug|Concentration" id="994" />
-        <Map s="T1|Organism|SmallIntestine|Mucosa|UpperJejunum|BloodCells|..|Blood flow rate" id="995" />
-        <Map s="T1|Neighborhoods|UpperJejunum_bc_PortalVein_bc|Drug|Mass transfer rate (mucosa to portal vein blood cells)" id="996" />
-        <Map s="MassTransferMucosaToPveBCRate" id="997" />
-        <Map s="T1|Organism|SmallIntestine|Mucosa|UpperJejunum|Plasma|Drug|Concentration" id="998" />
-        <Map s="T1|Organism|SmallIntestine|Mucosa|UpperJejunum|Plasma|..|Blood flow rate" id="999" />
-        <Map s="T1|Neighborhoods|UpperJejunum_pls_PortalVein_pls|Drug|Mass transfer rate (mucosa to portal vein plasma)" id="1000" />
-        <Map s="MassTransferMucosaToPvePlasmaRate" id="1001" />
-        <Map s="T1|Drug|Intestinal permeability (paracellular)" id="1002" />
-        <Map s="P_int_para" id="1003" />
-        <Map s="T1|Organism|Lumen|UpperJejunum|..|Paracellular absorption sink condition" id="1004" />
-        <Map s="k_Liquid_para" id="1005" />
-        <Map s="T1|Organism|Lumen|LowerJejunum|Effective surface area enhancement factor" id="1006" />
-        <Map s="T1|Organism|Lumen|LowerJejunum|Geometric surface area" id="1007" />
-        <Map s="T1|Organism|Lumen|LowerJejunum|Liquid" id="1008" />
-        <Map s="T1|Organism|SmallIntestine|Mucosa|LowerJejunum|Plasma|Drug|Concentration" id="1009" />
-        <Map s="T1|Organism|Lumen|LowerJejunum|Drug|Solubility" id="1010" />
-        <Map s="T1|Organism|Lumen|LowerJejunum|..|OralApplicationsEnabled" id="1011" />
-        <Map s="T1|Organism|Lumen|LowerJejunum|..|Paracellular absorption sink condition" id="1012" />
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-        <Map s="T1|Organism|Lumen|Stomach|..|OralApplicationsEnabled" id="1031" />
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-        <Map s="T1|Organism|Lumen|Duodenum|FillLevelFlag" id="1033" />
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-        <Map s="T1|Organism|Lumen|LowerJejunum|FillLevelFlag" id="1035" />
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-        <Map s="T1|Organism|Lumen|Caecum|FillLevelFlag" id="1041" />
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-        <Map s="T1|Organism|Lumen|ColonAscendens|FillLevelFlag" id="1044" />
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-        <Map s="T1|Organism|Lumen|Rectum|Intestinal transit rate (absolute)" id="1060" />
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-        <Map s="T1|Organism|Stomach|Interstitial|..|Vf (protein)" id="1062" />
-        <Map s="T1|Organism|Stomach|Interstitial|..|Vf (water)" id="1063" />
-        <Map s="T1|Neighborhoods|Stomach_pls_Stomach_int|Drug|Partition coefficient (interstitial/plasma)" id="1064" />
-        <Map s="T1|Organism|Stomach|Intracellular|Drug|Concentration" id="1065" />
-        <Map s="T1|Organism|Stomach|Interstitial|Drug|Concentration" id="1066" />
-        <Map s="T1|Neighborhoods|Stomach_int_Stomach_cell|Drug|P*SA interstitial -&gt; intracellular" id="1067" />
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-        <Map s="T1|Organism|Stomach|Interstitial|..|Volume" id="1069" />
-        <Map s="T1|Organism|Stomach|Plasma|..|Blood flow rate" id="1070" />
-        <Map s="T1|Organism|Stomach|Plasma|Drug|Concentration" id="1071" />
-        <Map s="T1|Organism|Stomach|BloodCells|..|Blood flow rate" id="1072" />
-        <Map s="T1|Organism|Stomach|BloodCells|Drug|Concentration" id="1073" />
-        <Map s="T1|Neighborhoods|Stomach_pls_Stomach_int|Drug|P (plasma&lt;-&gt;interstitial)" id="1074" />
-        <Map s="T1|Organism|Stomach|Plasma|..|Fraction vascular" id="1075" />
-        <Map s="T1|Organism|Stomach|Plasma|..|Volume" id="1076" />
-        <Map s="T1|Neighborhoods|Stomach_pls_Stomach_bc|Surface area (blood cells/plasma)" id="1077" />
-        <Map s="T1|Organism|Lumen|UpperIleum|Effective surface area enhancement factor" id="1078" />
-        <Map s="T1|Organism|Lumen|UpperIleum|Geometric surface area" id="1079" />
-        <Map s="T1|Organism|Lumen|UpperIleum|Liquid" id="1080" />
-        <Map s="T1|Organism|SmallIntestine|Mucosa|UpperIleum|Plasma|Drug|Concentration" id="1081" />
-        <Map s="T1|Organism|Lumen|UpperIleum|Drug|Solubility" id="1082" />
-        <Map s="T1|Organism|Lumen|UpperIleum|..|Paracellular absorption sink condition" id="1083" />
-        <Map s="T1|Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|pH" id="1084" />
-        <Map s="T1|Organism|Lumen|UpperIleum|pH" id="1085" />
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-        <Map s="T1|Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|Drug|Concentration" id="1087" />
-        <Map s="T1|Neighborhoods|Lumen_uil_UpperIleum_cell|Drug|P_int_trans_cell_lum_factor" id="1088" />
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-        <Map s="T1|Organism|Lumen|UpperIleum|..|Transcellular absorption sink condition" id="1090" />
-        <Map s="T1|Organism|SmallIntestine|Mucosa|UpperIleum|Plasma|..|Blood flow rate" id="1091" />
-        <Map s="T1|Neighborhoods|UpperIleum_pls_PortalVein_pls|Drug|Mass transfer rate (mucosa to portal vein plasma)" id="1092" />
-        <Map s="T1|Organism|SmallIntestine|Mucosa|UpperIleum|BloodCells|Drug|Concentration" id="1093" />
-        <Map s="T1|Organism|SmallIntestine|Mucosa|UpperIleum|BloodCells|..|Blood flow rate" id="1094" />
-        <Map s="T1|Neighborhoods|UpperIleum_bc_PortalVein_bc|Drug|Mass transfer rate (mucosa to portal vein blood cells)" id="1095" />
-        <Map s="T1|Organism|SmallIntestine|BloodCells|Drug|Concentration" id="1096" />
-        <Map s="T1|Organism|SmallIntestine|Plasma|Drug|Concentration" id="1097" />
-        <Map s="T1|Neighborhoods|SmallIntestine_pls_SmallIntestine_bc|Surface area (blood cells/plasma)" id="1098" />
-        <Map s="T1|Organism|SmallIntestine|Plasma|..|Fraction vascular" id="1099" />
-        <Map s="T1|Organism|SmallIntestine|Plasma|..|Volume" id="1100" />
-        <Map s="T1|Organism|SmallIntestine|Plasma|..|Volume (mucosa)" id="1101" />
-        <Map s="T1|Organism|SmallIntestine|BloodCells|..|Blood flow rate" id="1102" />
-        <Map s="T1|Organism|SmallIntestine|BloodCells|..|Mucosa blood flow fraction" id="1103" />
-        <Map s="C" id="1104" />
-        <Map s="T1|Organism|SmallIntestine|Interstitial|Drug|Concentration" id="1105" />
-        <Map s="T1|Neighborhoods|SmallIntestine_pls_SmallIntestine_int|Drug|P (plasma&lt;-&gt;interstitial)" id="1106" />
-        <Map s="T1|Neighborhoods|SmallIntestine_pls_SmallIntestine_int|Drug|Partition coefficient (interstitial/plasma)" id="1107" />
-        <Map s="T1|Organism|SmallIntestine|Plasma|..|Blood flow rate" id="1108" />
-        <Map s="T1|Organism|SmallIntestine|Plasma|..|Mucosa blood flow fraction" id="1109" />
-        <Map s="T1|Organism|SmallIntestine|Interstitial|..|Vf (lipid)" id="1110" />
-        <Map s="T1|Organism|SmallIntestine|Interstitial|..|Vf (protein)" id="1111" />
-        <Map s="T1|Organism|SmallIntestine|Interstitial|..|Vf (water)" id="1112" />
-        <Map s="T1|Organism|SmallIntestine|Intracellular|Drug|Concentration" id="1113" />
-        <Map s="T1|Neighborhoods|SmallIntestine_int_SmallIntestine_cell|Drug|P*SA interstitial -&gt; intracellular" id="1114" />
-        <Map s="T1|Neighborhoods|SmallIntestine_int_SmallIntestine_cell|Drug|P*SA intracellular -&gt; interstitial" id="1115" />
-        <Map s="T1|Organism|SmallIntestine|Interstitial|..|Volume" id="1116" />
-        <Map s="T1|Organism|SmallIntestine|Volume (mucosa)" id="1117" />
-        <Map s="T1|Organism|SmallIntestine|Mucosa|LowerIleum|BloodCells|..|Blood flow rate" id="1118" />
-        <Map s="T1|Neighborhoods|SmallIntestine_bc_LowerIleum_bc|Drug|Mass transfer rate (intestine to mucosa blood cells)" id="1119" />
-        <Map s="MassTransferIntestineToMucosaBCRate" id="1120" />
-        <Map s="T1|Organism|SmallIntestine|Mucosa|Duodenum|Plasma|..|Blood flow rate" id="1121" />
-        <Map s="T1|Neighborhoods|SmallIntestine_pls_Duodenum_pls|Drug|Mass transfer rate (intestine to mucosa plasma)" id="1122" />
-        <Map s="MassTransferIntestineToMucosaPlasmaRate" id="1123" />
-        <Map s="T1|Organism|SmallIntestine|Mucosa|Duodenum|BloodCells|..|Blood flow rate" id="1124" />
-        <Map s="T1|Neighborhoods|SmallIntestine_bc_Duodenum_bc|Drug|Mass transfer rate (intestine to mucosa blood cells)" id="1125" />
-        <Map s="T1|Neighborhoods|SmallIntestine_pls_UpperJejunum_pls|Drug|Mass transfer rate (intestine to mucosa plasma)" id="1126" />
-        <Map s="T1|Neighborhoods|SmallIntestine_bc_UpperJejunum_bc|Drug|Mass transfer rate (intestine to mucosa blood cells)" id="1127" />
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-        <Map s="T1|Neighborhoods|SmallIntestine_bc_LowerJejunum_bc|Drug|Mass transfer rate (intestine to mucosa blood cells)" id="1129" />
-        <Map s="T1|Neighborhoods|SmallIntestine_pls_UpperIleum_pls|Drug|Mass transfer rate (intestine to mucosa plasma)" id="1130" />
-        <Map s="T1|Neighborhoods|SmallIntestine_bc_UpperIleum_bc|Drug|Mass transfer rate (intestine to mucosa blood cells)" id="1131" />
-        <Map s="T1|Organism|Lumen|LowerIleum|Effective surface area enhancement factor" id="1132" />
-        <Map s="T1|Organism|Lumen|LowerIleum|Geometric surface area" id="1133" />
-        <Map s="T1|Organism|Lumen|LowerIleum|Liquid" id="1134" />
-        <Map s="T1|Organism|SmallIntestine|Mucosa|LowerIleum|Plasma|Drug|Concentration" id="1135" />
-        <Map s="T1|Organism|Lumen|LowerIleum|Drug|Solubility" id="1136" />
-        <Map s="T1|Organism|Lumen|LowerIleum|..|Paracellular absorption sink condition" id="1137" />
-        <Map s="T1|Organism|SmallIntestine|Mucosa|LowerIleum|Plasma|..|Blood flow rate" id="1138" />
-        <Map s="T1|Neighborhoods|SmallIntestine_pls_LowerIleum_pls|Drug|Mass transfer rate (intestine to mucosa plasma)" id="1139" />
-        <Map s="T1|Neighborhoods|LowerIleum_pls_PortalVein_pls|Drug|Mass transfer rate (mucosa to portal vein plasma)" id="1140" />
-        <Map s="T1|Organism|SmallIntestine|Mucosa|LowerIleum|BloodCells|Drug|Concentration" id="1141" />
-        <Map s="T1|Neighborhoods|LowerIleum_bc_PortalVein_bc|Drug|Mass transfer rate (mucosa to portal vein blood cells)" id="1142" />
-        <Map s="T1|Organism|Lumen|LowerIleum|pH" id="1143" />
-        <Map s="T1|Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|Drug|Concentration" id="1144" />
-        <Map s="T1|Neighborhoods|Lumen_lil_LowerIleum_cell|Drug|P_int_trans_cell_lum_factor" id="1145" />
-        <Map s="T1|Neighborhoods|Lumen_lil_LowerIleum_cell|Drug|P_int_trans_lum_cell_factor" id="1146" />
-        <Map s="T1|Organism|Lumen|LowerIleum|..|Transcellular absorption sink condition" id="1147" />
-        <Map s="T1|Neighborhoods|LowerIleum_int_LowerIleum_cell|Drug|Partition coefficient (intracellular/plasma)" id="1148" />
-        <Map s="T1|Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|pH" id="1149" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|Rectum|BloodCells|..|Blood flow rate" id="1150" />
-        <Map s="T1|Organism|LargeIntestine|BloodCells|Drug|Concentration" id="1151" />
-        <Map s="T1|Neighborhoods|LargeIntestine_bc_Rectum_bc|Drug|Mass transfer rate (intestine to mucosa blood cells)" id="1152" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|Rectum|Plasma|..|Blood flow rate" id="1153" />
-        <Map s="T1|Organism|LargeIntestine|Plasma|Drug|Concentration" id="1154" />
-        <Map s="T1|Neighborhoods|LargeIntestine_pls_Rectum_pls|Drug|Mass transfer rate (intestine to mucosa plasma)" id="1155" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|ColonSigmoid|BloodCells|..|Blood flow rate" id="1156" />
-        <Map s="T1|Neighborhoods|LargeIntestine_bc_ColonSigmoid_bc|Drug|Mass transfer rate (intestine to mucosa blood cells)" id="1157" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|ColonSigmoid|Plasma|..|Blood flow rate" id="1158" />
-        <Map s="T1|Neighborhoods|LargeIntestine_pls_ColonSigmoid_pls|Drug|Mass transfer rate (intestine to mucosa plasma)" id="1159" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|ColonDescendens|BloodCells|..|Blood flow rate" id="1160" />
-        <Map s="T1|Neighborhoods|LargeIntestine_bc_ColonDescendens_bc|Drug|Mass transfer rate (intestine to mucosa blood cells)" id="1161" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|ColonDescendens|Plasma|..|Blood flow rate" id="1162" />
-        <Map s="T1|Neighborhoods|LargeIntestine_pls_ColonDescendens_pls|Drug|Mass transfer rate (intestine to mucosa plasma)" id="1163" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|ColonTransversum|Plasma|..|Blood flow rate" id="1164" />
-        <Map s="T1|Neighborhoods|LargeIntestine_pls_ColonTransversum_pls|Drug|Mass transfer rate (intestine to mucosa plasma)" id="1165" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|ColonAscendens|BloodCells|..|Blood flow rate" id="1166" />
-        <Map s="T1|Neighborhoods|LargeIntestine_bc_ColonAscendens_bc|Drug|Mass transfer rate (intestine to mucosa blood cells)" id="1167" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|ColonAscendens|Plasma|..|Blood flow rate" id="1168" />
-        <Map s="T1|Neighborhoods|LargeIntestine_pls_ColonAscendens_pls|Drug|Mass transfer rate (intestine to mucosa plasma)" id="1169" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|Caecum|BloodCells|..|Blood flow rate" id="1170" />
-        <Map s="T1|Neighborhoods|LargeIntestine_bc_Caecum_bc|Drug|Mass transfer rate (intestine to mucosa blood cells)" id="1171" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|Caecum|Plasma|..|Blood flow rate" id="1172" />
-        <Map s="T1|Neighborhoods|LargeIntestine_pls_Caecum_pls|Drug|Mass transfer rate (intestine to mucosa plasma)" id="1173" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|ColonTransversum|BloodCells|..|Blood flow rate" id="1174" />
-        <Map s="T1|Neighborhoods|LargeIntestine_bc_ColonTransversum_bc|Drug|Mass transfer rate (intestine to mucosa blood cells)" id="1175" />
-        <Map s="T1|Organism|LargeIntestine|BloodCells|..|Blood flow rate" id="1176" />
-        <Map s="T1|Organism|LargeIntestine|BloodCells|..|Mucosa blood flow fraction" id="1177" />
-        <Map s="T1|Organism|LargeIntestine|Plasma|..|Blood flow rate" id="1178" />
-        <Map s="T1|Organism|LargeIntestine|Plasma|..|Mucosa blood flow fraction" id="1179" />
-        <Map s="T1|Organism|LargeIntestine|Interstitial|Drug|Concentration" id="1180" />
-        <Map s="T1|Neighborhoods|LargeIntestine_pls_LargeIntestine_int|Drug|P (plasma&lt;-&gt;interstitial)" id="1181" />
-        <Map s="T1|Neighborhoods|LargeIntestine_pls_LargeIntestine_int|Drug|Partition coefficient (interstitial/plasma)" id="1182" />
-        <Map s="T1|Organism|LargeIntestine|Plasma|..|Fraction vascular" id="1183" />
-        <Map s="T1|Organism|LargeIntestine|Plasma|..|Volume" id="1184" />
-        <Map s="T1|Organism|LargeIntestine|Plasma|..|Volume (mucosa)" id="1185" />
-        <Map s="T1|Neighborhoods|LargeIntestine_pls_LargeIntestine_bc|Surface area (blood cells/plasma)" id="1186" />
-        <Map s="T1|Organism|LargeIntestine|Interstitial|..|Vf (lipid)" id="1187" />
-        <Map s="T1|Organism|LargeIntestine|Interstitial|..|Vf (protein)" id="1188" />
-        <Map s="T1|Organism|LargeIntestine|Interstitial|..|Vf (water)" id="1189" />
-        <Map s="T1|Organism|LargeIntestine|Intracellular|Drug|Concentration" id="1190" />
-        <Map s="T1|Neighborhoods|LargeIntestine_int_LargeIntestine_cell|Drug|P*SA interstitial -&gt; intracellular" id="1191" />
-        <Map s="T1|Neighborhoods|LargeIntestine_int_LargeIntestine_cell|Drug|P*SA intracellular -&gt; interstitial" id="1192" />
-        <Map s="T1|Organism|LargeIntestine|Interstitial|..|Volume" id="1193" />
-        <Map s="T1|Organism|LargeIntestine|Volume (mucosa)" id="1194" />
-        <Map s="T1|Organism|Liver|BloodCells|Drug|Concentration" id="1195" />
-        <Map s="T1|Organism|Liver|Plasma|Drug|Concentration" id="1196" />
-        <Map s="T1|Neighborhoods|Liver_pls_Liver_bc|Surface area (blood cells/plasma)" id="1197" />
-        <Map s="T1|Organism|Liver|Plasma|..|Fraction vascular" id="1198" />
-        <Map s="T1|Organism|Liver|Plasma|..|Volume" id="1199" />
-        <Map s="T1|Organism|Liver|BloodCells|..|Blood flow rate" id="1200" />
-        <Map s="T1|Organism|Liver|BloodCells|..|..|PortalVein|Blood flow rate" id="1201" />
-        <Map s="Q_pve" id="1202" />
-        <Map s="T1|Organism|Liver|Interstitial|Drug|Concentration" id="1203" />
-        <Map s="T1|Neighborhoods|Liver_pls_Liver_int|Drug|P (plasma&lt;-&gt;interstitial)" id="1204" />
-        <Map s="T1|Neighborhoods|Liver_pls_Liver_int|Drug|Partition coefficient (interstitial/plasma)" id="1205" />
-        <Map s="T1|Organism|Liver|Plasma|..|Blood flow rate" id="1206" />
-        <Map s="T1|Organism|Liver|Plasma|..|..|PortalVein|Blood flow rate" id="1207" />
-        <Map s="..|P*SA interstitial -&gt; intracellular" id="1208" />
-        <Map s="PA_liv" id="1209" />
-        <Map s="T1|Organism|Liver|Interstitial|..|Blood flow rate" id="1210" />
-        <Map s="T1|Organism|Liver|Interstitial|..|..|PortalVein|Blood flow rate" id="1211" />
-        <Map s="T1|Organism|Liver|Interstitial|..|Vf (lipid)" id="1212" />
-        <Map s="T1|Organism|Liver|Interstitial|..|Vf (protein)" id="1213" />
-        <Map s="T1|Organism|Liver|Interstitial|..|Vf (water)" id="1214" />
-        <Map s="T1|Organism|Liver|Intracellular|Drug|Concentration" id="1215" />
-        <Map s="T1|Neighborhoods|Liver_int_Liver_cell|Drug|P*SA interstitial -&gt; intracellular" id="1216" />
-        <Map s="T1|Neighborhoods|Liver_int_Liver_cell|Drug|P*SA intracellular -&gt; interstitial" id="1217" />
-        <Map s="T1|Organism|Liver|Interstitial|..|Volume" id="1218" />
-        <Map s="T1|Organism|Gallbladder|Gallbladder emptying rate" id="1219" />
-        <Map s="GallbladderEmptyingRate" id="1220" />
-        <Map s="T1|Organism|Lung|BloodCells|Drug|Concentration" id="1221" />
-        <Map s="T1|Organism|Lung|Plasma|Drug|Concentration" id="1222" />
-        <Map s="T1|Neighborhoods|Lung_pls_Lung_bc|Surface area (blood cells/plasma)" id="1223" />
-        <Map s="T1|Organism|Lung|Plasma|..|Fraction vascular" id="1224" />
-        <Map s="T1|Organism|Lung|Plasma|..|Volume" id="1225" />
-        <Map s="T1|Organism|Lung|Interstitial|Drug|Concentration" id="1226" />
-        <Map s="T1|Neighborhoods|Lung_pls_Lung_int|Drug|P (plasma&lt;-&gt;interstitial)" id="1227" />
-        <Map s="T1|Neighborhoods|Lung_pls_Lung_int|Drug|Partition coefficient (interstitial/plasma)" id="1228" />
-        <Map s="T1|Organism|Lung|Interstitial|..|Vf (lipid)" id="1229" />
-        <Map s="T1|Organism|Lung|Interstitial|..|Vf (protein)" id="1230" />
-        <Map s="T1|Organism|Lung|Interstitial|..|Vf (water)" id="1231" />
-        <Map s="T1|Organism|Lung|Intracellular|Drug|Concentration" id="1232" />
-        <Map s="T1|Neighborhoods|Lung_int_Lung_cell|Drug|P*SA interstitial -&gt; intracellular" id="1233" />
-        <Map s="T1|Neighborhoods|Lung_int_Lung_cell|Drug|P*SA intracellular -&gt; interstitial" id="1234" />
-        <Map s="T1|Organism|Lung|Interstitial|..|Volume" id="1235" />
-        <Map s="T1|Organism|Muscle|Interstitial|..|Vf (lipid)" id="1236" />
-        <Map s="T1|Organism|Muscle|Interstitial|..|Vf (protein)" id="1237" />
-        <Map s="T1|Organism|Muscle|Interstitial|..|Vf (water)" id="1238" />
-        <Map s="T1|Neighborhoods|Muscle_pls_Muscle_int|Drug|Partition coefficient (interstitial/plasma)" id="1239" />
-        <Map s="T1|Organism|Muscle|Intracellular|Drug|Concentration" id="1240" />
-        <Map s="T1|Organism|Muscle|Interstitial|Drug|Concentration" id="1241" />
-        <Map s="T1|Neighborhoods|Muscle_int_Muscle_cell|Drug|P*SA interstitial -&gt; intracellular" id="1242" />
-        <Map s="T1|Neighborhoods|Muscle_int_Muscle_cell|Drug|P*SA intracellular -&gt; interstitial" id="1243" />
-        <Map s="T1|Organism|Muscle|Interstitial|..|Volume" id="1244" />
-        <Map s="T1|Neighborhoods|Muscle_pls_Muscle_bc|Surface area (blood cells/plasma)" id="1245" />
-        <Map s="T1|Organism|Muscle|Plasma|..|Fraction vascular" id="1246" />
-        <Map s="T1|Organism|Muscle|Plasma|..|Volume" id="1247" />
-        <Map s="T1|Organism|Muscle|Plasma|..|Blood flow rate" id="1248" />
-        <Map s="T1|Neighborhoods|Muscle_pls_Muscle_int|Drug|P (plasma&lt;-&gt;interstitial)" id="1249" />
-        <Map s="T1|Organism|Muscle|BloodCells|..|Blood flow rate" id="1250" />
-        <Map s="T1|Organism|Pancreas|BloodCells|..|Blood flow rate" id="1251" />
-        <Map s="T1|Organism|Pancreas|BloodCells|Drug|Concentration" id="1252" />
-        <Map s="T1|Organism|Pancreas|Plasma|..|Blood flow rate" id="1253" />
-        <Map s="T1|Organism|Pancreas|Plasma|Drug|Concentration" id="1254" />
-        <Map s="T1|Organism|Pancreas|Interstitial|Drug|Concentration" id="1255" />
-        <Map s="T1|Neighborhoods|Pancreas_pls_Pancreas_int|Drug|P (plasma&lt;-&gt;interstitial)" id="1256" />
-        <Map s="T1|Neighborhoods|Pancreas_pls_Pancreas_int|Drug|Partition coefficient (interstitial/plasma)" id="1257" />
-        <Map s="T1|Organism|Pancreas|Plasma|..|Fraction vascular" id="1258" />
-        <Map s="T1|Organism|Pancreas|Plasma|..|Volume" id="1259" />
-        <Map s="T1|Neighborhoods|Pancreas_pls_Pancreas_bc|Surface area (blood cells/plasma)" id="1260" />
-        <Map s="T1|Organism|Pancreas|Interstitial|..|Vf (lipid)" id="1261" />
-        <Map s="T1|Organism|Pancreas|Interstitial|..|Vf (protein)" id="1262" />
-        <Map s="T1|Organism|Pancreas|Interstitial|..|Vf (water)" id="1263" />
-        <Map s="T1|Organism|Pancreas|Intracellular|Drug|Concentration" id="1264" />
-        <Map s="T1|Neighborhoods|Pancreas_int_Pancreas_cell|Drug|P*SA interstitial -&gt; intracellular" id="1265" />
-        <Map s="T1|Neighborhoods|Pancreas_int_Pancreas_cell|Drug|P*SA intracellular -&gt; interstitial" id="1266" />
-        <Map s="T1|Organism|Pancreas|Interstitial|..|Volume" id="1267" />
-        <Map s="T1|Organism|Lumen|Rectum|pH" id="1268" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|Rectum|Intracellular|pH" id="1269" />
-        <Map s="T1|Organism|Lumen|Rectum|Effective surface area enhancement factor" id="1270" />
-        <Map s="T1|Organism|Lumen|Rectum|Geometric surface area" id="1271" />
-        <Map s="T1|Organism|Lumen|Rectum|Liquid" id="1272" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|Rectum|Intracellular|Drug|Concentration" id="1273" />
-        <Map s="T1|Neighborhoods|Lumen_rect_Rectum_cell|Drug|P_int_trans_cell_lum_factor" id="1274" />
-        <Map s="T1|Neighborhoods|Lumen_rect_Rectum_cell|Drug|P_int_trans_lum_cell_factor" id="1275" />
-        <Map s="T1|Organism|Lumen|Rectum|Drug|Solubility" id="1276" />
-        <Map s="T1|Organism|Lumen|Rectum|..|Transcellular absorption sink condition" id="1277" />
-        <Map s="T1|Neighborhoods|Rectum_int_Rectum_cell|Drug|Partition coefficient (intracellular/plasma)" id="1278" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|Rectum|BloodCells|Drug|Concentration" id="1279" />
-        <Map s="T1|Neighborhoods|Rectum_bc_PortalVein_bc|Drug|Mass transfer rate (mucosa to portal vein blood cells)" id="1280" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|Rectum|Plasma|Drug|Concentration" id="1281" />
-        <Map s="T1|Neighborhoods|Rectum_pls_PortalVein_pls|Drug|Mass transfer rate (mucosa to portal vein plasma)" id="1282" />
-        <Map s="T1|Organism|Lumen|Rectum|..|Paracellular absorption sink condition" id="1283" />
-        <Map s="T1|Organism|PortalVein|BloodCells|Drug|Concentration" id="1284" />
-        <Map s="T1|Organism|PortalVein|Plasma|Drug|Concentration" id="1285" />
-        <Map s="T1|Neighborhoods|PortalVein_pls_PortalVein_bc|Surface area (blood cells/plasma)" id="1286" />
-        <Map s="T1|Organism|PortalVein|Plasma|..|Volume" id="1287" />
-        <Map s="T1|Organism|PortalVein|BloodCells|..|Blood flow rate" id="1288" />
-        <Map s="T1|Organism|PortalVein|Plasma|..|Blood flow rate" id="1289" />
-        <Map s="T1|Neighborhoods|Skin_pls_Skin_bc|Surface area (blood cells/plasma)" id="1290" />
-        <Map s="T1|Organism|Skin|Plasma|..|Fraction vascular" id="1291" />
-        <Map s="T1|Organism|Skin|Plasma|..|Volume" id="1292" />
-        <Map s="T1|Organism|Skin|Interstitial|..|Vf (lipid)" id="1293" />
-        <Map s="T1|Organism|Skin|Interstitial|..|Vf (protein)" id="1294" />
-        <Map s="T1|Organism|Skin|Interstitial|..|Vf (water)" id="1295" />
-        <Map s="T1|Neighborhoods|Skin_pls_Skin_int|Drug|Partition coefficient (interstitial/plasma)" id="1296" />
-        <Map s="T1|Organism|Skin|Intracellular|Drug|Concentration" id="1297" />
-        <Map s="T1|Organism|Skin|Interstitial|Drug|Concentration" id="1298" />
-        <Map s="T1|Neighborhoods|Skin_int_Skin_cell|Drug|P*SA interstitial -&gt; intracellular" id="1299" />
-        <Map s="T1|Neighborhoods|Skin_int_Skin_cell|Drug|P*SA intracellular -&gt; interstitial" id="1300" />
-        <Map s="T1|Organism|Skin|Interstitial|..|Volume" id="1301" />
-        <Map s="T1|Organism|Skin|BloodCells|..|Blood flow rate" id="1302" />
-        <Map s="T1|Neighborhoods|Skin_pls_Skin_int|Drug|P (plasma&lt;-&gt;interstitial)" id="1303" />
-        <Map s="T1|Organism|Skin|Plasma|..|Blood flow rate" id="1304" />
-        <Map s="T1|Organism|Spleen|BloodCells|..|Blood flow rate" id="1305" />
-        <Map s="T1|Organism|Spleen|BloodCells|Drug|Concentration" id="1306" />
-        <Map s="T1|Organism|Spleen|Interstitial|..|Vf (lipid)" id="1307" />
-        <Map s="T1|Organism|Spleen|Interstitial|..|Vf (protein)" id="1308" />
-        <Map s="T1|Organism|Spleen|Interstitial|..|Vf (water)" id="1309" />
-        <Map s="T1|Neighborhoods|Spleen_pls_Spleen_int|Drug|Partition coefficient (interstitial/plasma)" id="1310" />
-        <Map s="T1|Organism|Spleen|Intracellular|Drug|Concentration" id="1311" />
-        <Map s="T1|Organism|Spleen|Interstitial|Drug|Concentration" id="1312" />
-        <Map s="T1|Neighborhoods|Spleen_int_Spleen_cell|Drug|P*SA interstitial -&gt; intracellular" id="1313" />
-        <Map s="T1|Neighborhoods|Spleen_int_Spleen_cell|Drug|P*SA intracellular -&gt; interstitial" id="1314" />
-        <Map s="T1|Organism|Spleen|Interstitial|..|Volume" id="1315" />
-        <Map s="T1|Organism|Spleen|Plasma|Drug|Concentration" id="1316" />
-        <Map s="T1|Neighborhoods|Spleen_pls_Spleen_bc|Surface area (blood cells/plasma)" id="1317" />
-        <Map s="T1|Organism|Spleen|Plasma|..|Fraction vascular" id="1318" />
-        <Map s="T1|Organism|Spleen|Plasma|..|Volume" id="1319" />
-        <Map s="T1|Neighborhoods|Spleen_pls_Spleen_int|Drug|P (plasma&lt;-&gt;interstitial)" id="1320" />
-        <Map s="T1|Organism|Spleen|Plasma|..|Blood flow rate" id="1321" />
-        <Map s="..|SalivaPlasmaRatio" id="1322" />
-        <Map s="R" id="1323" />
-        <Map s="T1|Organism|Saliva|Saliva|pH (saliva)" id="1324" />
-        <Map s="pH_slv" id="1325" />
-        <Map s="T1|Organism|pH (plasma)" id="1326" />
-        <Map s="pH_PLS" id="1327" />
-        <Map s="T1|Organism|Saliva|SalivaGland|..|Saliva flow rate" id="1328" />
-        <Map s="Q_slv" id="1329" />
-        <Map s="T1|Organism|Saliva|SalivaGland|..|..|ArterialBlood|Plasma|Drug|Concentration" id="1330" />
-        <Map s="T1|Organism|Saliva|Saliva|Drug|Concentration" id="1331" />
-        <Map s="C_slv" id="1332" />
-        <Map s="T1|Neighborhoods|Saliva_slv_Saliva_slv|Drug|Partition coefficient (intracellular/plasma)" id="1333" />
-        <Map s="K_slv_pls" id="1334" />
-        <Map s="T1|Organism|SmallIntestine|Mucosa|Duodenum|Interstitial|Drug|Concentration" id="1335" />
-        <Map s="T1|Organism|SmallIntestine|Mucosa|Duodenum|Plasma|Drug|Concentration" id="1336" />
-        <Map s="T1|Neighborhoods|Duodenum_pls_Duodenum_int|Drug|P (plasma&lt;-&gt;interstitial)" id="1337" />
-        <Map s="T1|Neighborhoods|Duodenum_pls_Duodenum_int|Drug|Partition coefficient (interstitial/plasma)" id="1338" />
-        <Map s="T1|Organism|SmallIntestine|Mucosa|Duodenum|Plasma|..|Fraction vascular" id="1339" />
-        <Map s="T1|Organism|SmallIntestine|Mucosa|Duodenum|Plasma|..|Volume" id="1340" />
-        <Map s="T1|Organism|SmallIntestine|Mucosa|Duodenum|BloodCells|Drug|Concentration" id="1341" />
-        <Map s="T1|Neighborhoods|Duodenum_pls_Duodenum_bc|Surface area (blood cells/plasma)" id="1342" />
-        <Map s="T1|Organism|SmallIntestine|Mucosa|Duodenum|Interstitial|..|Vf (lipid)" id="1343" />
-        <Map s="T1|Organism|SmallIntestine|Mucosa|Duodenum|Interstitial|..|Vf (protein)" id="1344" />
-        <Map s="T1|Organism|SmallIntestine|Mucosa|Duodenum|Interstitial|..|Vf (water)" id="1345" />
-        <Map s="T1|Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|Drug|Concentration" id="1346" />
-        <Map s="T1|Neighborhoods|Duodenum_int_Duodenum_cell|Drug|P*SA interstitial -&gt; intracellular" id="1347" />
-        <Map s="T1|Neighborhoods|Duodenum_int_Duodenum_cell|Drug|P*SA intracellular -&gt; interstitial" id="1348" />
-        <Map s="T1|Organism|Lumen|Duodenum|Effective surface area enhancement factor" id="1349" />
-        <Map s="T1|Organism|Lumen|Duodenum|Geometric surface area" id="1350" />
-        <Map s="T1|Organism|Lumen|Duodenum|Microvilli factor" id="1351" />
-        <Map s="MicrovilliFactor" id="1352" />
-        <Map s="T1|Neighborhoods|UpperJejunum_pls_UpperJejunum_bc|Surface area (blood cells/plasma)" id="1353" />
-        <Map s="T1|Organism|SmallIntestine|Mucosa|UpperJejunum|Plasma|..|Fraction vascular" id="1354" />
-        <Map s="T1|Organism|SmallIntestine|Mucosa|UpperJejunum|Plasma|..|Volume" id="1355" />
-        <Map s="T1|Organism|SmallIntestine|Mucosa|UpperJejunum|Interstitial|..|Vf (lipid)" id="1356" />
-        <Map s="T1|Organism|SmallIntestine|Mucosa|UpperJejunum|Interstitial|..|Vf (protein)" id="1357" />
-        <Map s="T1|Organism|SmallIntestine|Mucosa|UpperJejunum|Interstitial|..|Vf (water)" id="1358" />
-        <Map s="T1|Organism|SmallIntestine|Mucosa|UpperJejunum|Interstitial|Drug|Concentration" id="1359" />
-        <Map s="T1|Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Drug|P*SA interstitial -&gt; intracellular" id="1360" />
-        <Map s="T1|Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Drug|P*SA intracellular -&gt; interstitial" id="1361" />
-        <Map s="T1|Organism|Lumen|UpperJejunum|Microvilli factor" id="1362" />
-        <Map s="T1|Neighborhoods|UpperJejunum_pls_UpperJejunum_int|Drug|P (plasma&lt;-&gt;interstitial)" id="1363" />
-        <Map s="T1|Neighborhoods|UpperJejunum_pls_UpperJejunum_int|Drug|Partition coefficient (interstitial/plasma)" id="1364" />
-        <Map s="T1|Organism|SmallIntestine|Mucosa|LowerJejunum|Interstitial|Drug|Concentration" id="1365" />
-        <Map s="T1|Neighborhoods|LowerJejunum_pls_LowerJejunum_int|Drug|P (plasma&lt;-&gt;interstitial)" id="1366" />
-        <Map s="T1|Neighborhoods|LowerJejunum_pls_LowerJejunum_int|Drug|Partition coefficient (interstitial/plasma)" id="1367" />
-        <Map s="T1|Organism|SmallIntestine|Mucosa|LowerJejunum|Plasma|..|Fraction vascular" id="1368" />
-        <Map s="T1|Organism|SmallIntestine|Mucosa|LowerJejunum|Plasma|..|Volume" id="1369" />
-        <Map s="T1|Neighborhoods|LowerJejunum_pls_LowerJejunum_bc|Surface area (blood cells/plasma)" id="1370" />
-        <Map s="T1|Organism|SmallIntestine|Mucosa|LowerJejunum|Interstitial|..|Vf (lipid)" id="1371" />
-        <Map s="T1|Organism|SmallIntestine|Mucosa|LowerJejunum|Interstitial|..|Vf (protein)" id="1372" />
-        <Map s="T1|Organism|SmallIntestine|Mucosa|LowerJejunum|Interstitial|..|Vf (water)" id="1373" />
-        <Map s="T1|Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Drug|P*SA interstitial -&gt; intracellular" id="1374" />
-        <Map s="T1|Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Drug|P*SA intracellular -&gt; interstitial" id="1375" />
-        <Map s="T1|Organism|Lumen|LowerJejunum|Microvilli factor" id="1376" />
-        <Map s="T1|Organism|SmallIntestine|Mucosa|UpperIleum|Interstitial|Drug|Concentration" id="1377" />
-        <Map s="T1|Neighborhoods|UpperIleum_pls_UpperIleum_int|Drug|P (plasma&lt;-&gt;interstitial)" id="1378" />
-        <Map s="T1|Neighborhoods|UpperIleum_pls_UpperIleum_int|Drug|Partition coefficient (interstitial/plasma)" id="1379" />
-        <Map s="T1|Organism|SmallIntestine|Mucosa|UpperIleum|Plasma|..|Fraction vascular" id="1380" />
-        <Map s="T1|Organism|SmallIntestine|Mucosa|UpperIleum|Plasma|..|Volume" id="1381" />
-        <Map s="T1|Neighborhoods|UpperIleum_pls_UpperIleum_bc|Surface area (blood cells/plasma)" id="1382" />
-        <Map s="T1|Organism|SmallIntestine|Mucosa|UpperIleum|Interstitial|..|Vf (lipid)" id="1383" />
-        <Map s="T1|Organism|SmallIntestine|Mucosa|UpperIleum|Interstitial|..|Vf (protein)" id="1384" />
-        <Map s="T1|Organism|SmallIntestine|Mucosa|UpperIleum|Interstitial|..|Vf (water)" id="1385" />
-        <Map s="T1|Neighborhoods|UpperIleum_int_UpperIleum_cell|Drug|P*SA interstitial -&gt; intracellular" id="1386" />
-        <Map s="T1|Neighborhoods|UpperIleum_int_UpperIleum_cell|Drug|P*SA intracellular -&gt; interstitial" id="1387" />
-        <Map s="T1|Organism|Lumen|UpperIleum|Microvilli factor" id="1388" />
-        <Map s="T1|Organism|SmallIntestine|Mucosa|LowerIleum|Interstitial|Drug|Concentration" id="1389" />
-        <Map s="T1|Neighborhoods|LowerIleum_pls_LowerIleum_int|Drug|P (plasma&lt;-&gt;interstitial)" id="1390" />
-        <Map s="T1|Neighborhoods|LowerIleum_pls_LowerIleum_int|Drug|Partition coefficient (interstitial/plasma)" id="1391" />
-        <Map s="T1|Organism|SmallIntestine|Mucosa|LowerIleum|Plasma|..|Fraction vascular" id="1392" />
-        <Map s="T1|Organism|SmallIntestine|Mucosa|LowerIleum|Plasma|..|Volume" id="1393" />
-        <Map s="T1|Neighborhoods|LowerIleum_pls_LowerIleum_bc|Surface area (blood cells/plasma)" id="1394" />
-        <Map s="T1|Organism|SmallIntestine|Mucosa|LowerIleum|Interstitial|..|Vf (lipid)" id="1395" />
-        <Map s="T1|Organism|SmallIntestine|Mucosa|LowerIleum|Interstitial|..|Vf (protein)" id="1396" />
-        <Map s="T1|Organism|SmallIntestine|Mucosa|LowerIleum|Interstitial|..|Vf (water)" id="1397" />
-        <Map s="T1|Neighborhoods|LowerIleum_int_LowerIleum_cell|Drug|P*SA interstitial -&gt; intracellular" id="1398" />
-        <Map s="T1|Neighborhoods|LowerIleum_int_LowerIleum_cell|Drug|P*SA intracellular -&gt; interstitial" id="1399" />
-        <Map s="T1|Organism|Lumen|LowerIleum|Microvilli factor" id="1400" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|Caecum|Interstitial|Drug|Concentration" id="1401" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|Caecum|Plasma|Drug|Concentration" id="1402" />
-        <Map s="T1|Neighborhoods|Caecum_pls_Caecum_int|Drug|P (plasma&lt;-&gt;interstitial)" id="1403" />
-        <Map s="T1|Neighborhoods|Caecum_pls_Caecum_int|Drug|Partition coefficient (interstitial/plasma)" id="1404" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|Caecum|Plasma|..|Fraction vascular" id="1405" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|Caecum|Plasma|..|Volume" id="1406" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|Caecum|BloodCells|Drug|Concentration" id="1407" />
-        <Map s="T1|Neighborhoods|Caecum_pls_Caecum_bc|Surface area (blood cells/plasma)" id="1408" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|Caecum|Interstitial|..|Vf (lipid)" id="1409" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|Caecum|Interstitial|..|Vf (protein)" id="1410" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|Caecum|Interstitial|..|Vf (water)" id="1411" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|Caecum|Intracellular|Drug|Concentration" id="1412" />
-        <Map s="T1|Neighborhoods|Caecum_int_Caecum_cell|Drug|P*SA interstitial -&gt; intracellular" id="1413" />
-        <Map s="T1|Neighborhoods|Caecum_int_Caecum_cell|Drug|P*SA intracellular -&gt; interstitial" id="1414" />
-        <Map s="T1|Organism|Lumen|Caecum|Effective surface area enhancement factor" id="1415" />
-        <Map s="T1|Organism|Lumen|Caecum|Geometric surface area" id="1416" />
-        <Map s="T1|Organism|Lumen|Caecum|Microvilli factor" id="1417" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|ColonAscendens|Interstitial|Drug|Concentration" id="1418" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|ColonAscendens|Plasma|Drug|Concentration" id="1419" />
-        <Map s="T1|Neighborhoods|ColonAscendens_pls_ColonAscendens_int|Drug|P (plasma&lt;-&gt;interstitial)" id="1420" />
-        <Map s="T1|Neighborhoods|ColonAscendens_pls_ColonAscendens_int|Drug|Partition coefficient (interstitial/plasma)" id="1421" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|ColonAscendens|Plasma|..|Fraction vascular" id="1422" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|ColonAscendens|Plasma|..|Volume" id="1423" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|ColonAscendens|Interstitial|..|Vf (lipid)" id="1424" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|ColonAscendens|Interstitial|..|Vf (protein)" id="1425" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|ColonAscendens|Interstitial|..|Vf (water)" id="1426" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|Drug|Concentration" id="1427" />
-        <Map s="T1|Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Drug|P*SA interstitial -&gt; intracellular" id="1428" />
-        <Map s="T1|Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Drug|P*SA intracellular -&gt; interstitial" id="1429" />
-        <Map s="T1|Organism|Lumen|ColonAscendens|Effective surface area enhancement factor" id="1430" />
-        <Map s="T1|Organism|Lumen|ColonAscendens|Geometric surface area" id="1431" />
-        <Map s="T1|Organism|Lumen|ColonAscendens|Microvilli factor" id="1432" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|ColonAscendens|BloodCells|Drug|Concentration" id="1433" />
-        <Map s="T1|Neighborhoods|ColonAscendens_pls_ColonAscendens_bc|Surface area (blood cells/plasma)" id="1434" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|ColonTransversum|BloodCells|Drug|Concentration" id="1435" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|ColonTransversum|Plasma|Drug|Concentration" id="1436" />
-        <Map s="T1|Neighborhoods|ColonTransversum_pls_ColonTransversum_bc|Surface area (blood cells/plasma)" id="1437" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|ColonTransversum|Plasma|..|Fraction vascular" id="1438" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|ColonTransversum|Plasma|..|Volume" id="1439" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|ColonTransversum|Interstitial|Drug|Concentration" id="1440" />
-        <Map s="T1|Neighborhoods|ColonTransversum_pls_ColonTransversum_int|Drug|P (plasma&lt;-&gt;interstitial)" id="1441" />
-        <Map s="T1|Neighborhoods|ColonTransversum_pls_ColonTransversum_int|Drug|Partition coefficient (interstitial/plasma)" id="1442" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|ColonTransversum|Interstitial|..|Vf (lipid)" id="1443" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|ColonTransversum|Interstitial|..|Vf (protein)" id="1444" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|ColonTransversum|Interstitial|..|Vf (water)" id="1445" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|Drug|Concentration" id="1446" />
-        <Map s="T1|Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Drug|P*SA interstitial -&gt; intracellular" id="1447" />
-        <Map s="T1|Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Drug|P*SA intracellular -&gt; interstitial" id="1448" />
-        <Map s="T1|Organism|Lumen|ColonTransversum|Effective surface area enhancement factor" id="1449" />
-        <Map s="T1|Organism|Lumen|ColonTransversum|Geometric surface area" id="1450" />
-        <Map s="T1|Organism|Lumen|ColonTransversum|Microvilli factor" id="1451" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|ColonDescendens|Interstitial|Drug|Concentration" id="1452" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|ColonDescendens|Plasma|Drug|Concentration" id="1453" />
-        <Map s="T1|Neighborhoods|ColonDescendens_pls_ColonDescendens_int|Drug|P (plasma&lt;-&gt;interstitial)" id="1454" />
-        <Map s="T1|Neighborhoods|ColonDescendens_pls_ColonDescendens_int|Drug|Partition coefficient (interstitial/plasma)" id="1455" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|ColonDescendens|Plasma|..|Fraction vascular" id="1456" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|ColonDescendens|Plasma|..|Volume" id="1457" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|ColonDescendens|BloodCells|Drug|Concentration" id="1458" />
-        <Map s="T1|Neighborhoods|ColonDescendens_pls_ColonDescendens_bc|Surface area (blood cells/plasma)" id="1459" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|ColonDescendens|Interstitial|..|Vf (lipid)" id="1460" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|ColonDescendens|Interstitial|..|Vf (protein)" id="1461" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|ColonDescendens|Interstitial|..|Vf (water)" id="1462" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|Drug|Concentration" id="1463" />
-        <Map s="T1|Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Drug|P*SA interstitial -&gt; intracellular" id="1464" />
-        <Map s="T1|Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Drug|P*SA intracellular -&gt; interstitial" id="1465" />
-        <Map s="T1|Organism|Lumen|ColonDescendens|Effective surface area enhancement factor" id="1466" />
-        <Map s="T1|Organism|Lumen|ColonDescendens|Geometric surface area" id="1467" />
-        <Map s="T1|Organism|Lumen|ColonDescendens|Microvilli factor" id="1468" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|ColonSigmoid|Interstitial|Drug|Concentration" id="1469" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|ColonSigmoid|Plasma|Drug|Concentration" id="1470" />
-        <Map s="T1|Neighborhoods|ColonSigmoid_pls_ColonSigmoid_int|Drug|P (plasma&lt;-&gt;interstitial)" id="1471" />
-        <Map s="T1|Neighborhoods|ColonSigmoid_pls_ColonSigmoid_int|Drug|Partition coefficient (interstitial/plasma)" id="1472" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|ColonSigmoid|Plasma|..|Fraction vascular" id="1473" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|ColonSigmoid|Plasma|..|Volume" id="1474" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|ColonSigmoid|BloodCells|Drug|Concentration" id="1475" />
-        <Map s="T1|Neighborhoods|ColonSigmoid_pls_ColonSigmoid_bc|Surface area (blood cells/plasma)" id="1476" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|ColonSigmoid|Interstitial|..|Vf (lipid)" id="1477" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|ColonSigmoid|Interstitial|..|Vf (protein)" id="1478" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|ColonSigmoid|Interstitial|..|Vf (water)" id="1479" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|Drug|Concentration" id="1480" />
-        <Map s="T1|Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Drug|P*SA interstitial -&gt; intracellular" id="1481" />
-        <Map s="T1|Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Drug|P*SA intracellular -&gt; interstitial" id="1482" />
-        <Map s="T1|Organism|Lumen|ColonSigmoid|Effective surface area enhancement factor" id="1483" />
-        <Map s="T1|Organism|Lumen|ColonSigmoid|Geometric surface area" id="1484" />
-        <Map s="T1|Organism|Lumen|ColonSigmoid|Microvilli factor" id="1485" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|Rectum|Interstitial|..|Vf (lipid)" id="1486" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|Rectum|Interstitial|..|Vf (protein)" id="1487" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|Rectum|Interstitial|..|Vf (water)" id="1488" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|Rectum|Interstitial|Drug|Concentration" id="1489" />
-        <Map s="T1|Neighborhoods|Rectum_int_Rectum_cell|Drug|P*SA interstitial -&gt; intracellular" id="1490" />
-        <Map s="T1|Neighborhoods|Rectum_int_Rectum_cell|Drug|P*SA intracellular -&gt; interstitial" id="1491" />
-        <Map s="T1|Organism|Lumen|Rectum|Microvilli factor" id="1492" />
-        <Map s="T1|Neighborhoods|Rectum_pls_Rectum_bc|Surface area (blood cells/plasma)" id="1493" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|Rectum|Plasma|..|Fraction vascular" id="1494" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|Rectum|Plasma|..|Volume" id="1495" />
-        <Map s="T1|Neighborhoods|Rectum_pls_Rectum_int|Drug|P (plasma&lt;-&gt;interstitial)" id="1496" />
-        <Map s="T1|Neighborhoods|Rectum_pls_Rectum_int|Drug|Partition coefficient (interstitial/plasma)" id="1497" />
-        <Map s="T1|Neighborhoods|ColonTransversum_pls_PortalVein_pls|Drug|Mass transfer rate (mucosa to portal vein plasma)" id="1498" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|pH" id="1499" />
-        <Map s="T1|Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Drug|Partition coefficient (intracellular/plasma)" id="1500" />
-        <Map s="T1|Organism|Lumen|ColonSigmoid|Liquid" id="1501" />
-        <Map s="T1|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|Drug|P_int_trans_cell_lum_factor" id="1502" />
-        <Map s="T1|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|Drug|P_int_trans_lum_cell_factor" id="1503" />
-        <Map s="T1|Organism|Lumen|ColonSigmoid|Drug|Solubility" id="1504" />
-        <Map s="T1|Organism|Lumen|ColonSigmoid|..|Transcellular absorption sink condition" id="1505" />
-        <Map s="T1|Organism|Lumen|ColonSigmoid|pH" id="1506" />
-        <Map s="T1|Neighborhoods|Caecum_bc_PortalVein_bc|Drug|Mass transfer rate (mucosa to portal vein blood cells)" id="1507" />
-        <Map s="T1|Organism|Lumen|ColonAscendens|Liquid" id="1508" />
-        <Map s="T1|Organism|Lumen|ColonAscendens|Drug|Solubility" id="1509" />
-        <Map s="T1|Organism|Lumen|ColonAscendens|..|Paracellular absorption sink condition" id="1510" />
-        <Map s="T1|Organism|Lumen|ColonAscendens|pH" id="1511" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|pH" id="1512" />
-        <Map s="T1|Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Drug|Partition coefficient (intracellular/plasma)" id="1513" />
-        <Map s="T1|Neighborhoods|Lumen_colasc_ColonAscendens_cell|Drug|P_int_trans_cell_lum_factor" id="1514" />
-        <Map s="T1|Neighborhoods|Lumen_colasc_ColonAscendens_cell|Drug|P_int_trans_lum_cell_factor" id="1515" />
-        <Map s="T1|Organism|Lumen|ColonAscendens|..|Transcellular absorption sink condition" id="1516" />
-        <Map s="T1|Neighborhoods|ColonAscendens_pls_PortalVein_pls|Drug|Mass transfer rate (mucosa to portal vein plasma)" id="1517" />
-        <Map s="T1|Neighborhoods|ColonAscendens_bc_PortalVein_bc|Drug|Mass transfer rate (mucosa to portal vein blood cells)" id="1518" />
-        <Map s="T1|Organism|Lumen|Caecum|Liquid" id="1519" />
-        <Map s="T1|Neighborhoods|Lumen_cae_Caecum_cell|Drug|P_int_trans_cell_lum_factor" id="1520" />
-        <Map s="T1|Neighborhoods|Lumen_cae_Caecum_cell|Drug|P_int_trans_lum_cell_factor" id="1521" />
-        <Map s="T1|Organism|Lumen|Caecum|Drug|Solubility" id="1522" />
-        <Map s="T1|Organism|Lumen|Caecum|..|Transcellular absorption sink condition" id="1523" />
-        <Map s="T1|Neighborhoods|Caecum_int_Caecum_cell|Drug|Partition coefficient (intracellular/plasma)" id="1524" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|Caecum|Intracellular|pH" id="1525" />
-        <Map s="T1|Organism|Lumen|Caecum|pH" id="1526" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|pH" id="1527" />
-        <Map s="T1|Organism|Lumen|ColonTransversum|pH" id="1528" />
-        <Map s="T1|Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Drug|Partition coefficient (intracellular/plasma)" id="1529" />
-        <Map s="T1|Organism|Lumen|ColonTransversum|Liquid" id="1530" />
-        <Map s="T1|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|Drug|P_int_trans_cell_lum_factor" id="1531" />
-        <Map s="T1|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|Drug|P_int_trans_lum_cell_factor" id="1532" />
-        <Map s="T1|Organism|Lumen|ColonTransversum|Drug|Solubility" id="1533" />
-        <Map s="T1|Organism|Lumen|ColonTransversum|..|Transcellular absorption sink condition" id="1534" />
-        <Map s="T1|Organism|Lumen|Caecum|..|Paracellular absorption sink condition" id="1535" />
-        <Map s="T1|Neighborhoods|ColonTransversum_bc_PortalVein_bc|Drug|Mass transfer rate (mucosa to portal vein blood cells)" id="1536" />
-        <Map s="T1|Organism|Lumen|ColonDescendens|Liquid" id="1537" />
-        <Map s="T1|Organism|Lumen|ColonDescendens|Drug|Solubility" id="1538" />
-        <Map s="T1|Organism|Lumen|ColonDescendens|..|Paracellular absorption sink condition" id="1539" />
-        <Map s="T1|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|Drug|P_int_trans_cell_lum_factor" id="1540" />
-        <Map s="T1|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|Drug|P_int_trans_lum_cell_factor" id="1541" />
-        <Map s="T1|Organism|Lumen|ColonDescendens|..|Transcellular absorption sink condition" id="1542" />
-        <Map s="T1|Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|pH" id="1543" />
-        <Map s="T1|Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Drug|Partition coefficient (intracellular/plasma)" id="1544" />
-        <Map s="T1|Organism|Lumen|ColonDescendens|pH" id="1545" />
-        <Map s="T1|Neighborhoods|ColonDescendens_pls_PortalVein_pls|Drug|Mass transfer rate (mucosa to portal vein plasma)" id="1546" />
-        <Map s="T1|Neighborhoods|ColonDescendens_bc_PortalVein_bc|Drug|Mass transfer rate (mucosa to portal vein blood cells)" id="1547" />
-        <Map s="T1|Organism|Lumen|ColonTransversum|..|Paracellular absorption sink condition" id="1548" />
-        <Map s="T1|Neighborhoods|Caecum_pls_PortalVein_pls|Drug|Mass transfer rate (mucosa to portal vein plasma)" id="1549" />
-        <Map s="T1|Neighborhoods|ColonSigmoid_pls_PortalVein_pls|Drug|Mass transfer rate (mucosa to portal vein plasma)" id="1550" />
-        <Map s="T1|Organism|Lumen|Duodenum|Liquid" id="1551" />
-        <Map s="T1|Organism|Lumen|Duodenum|Drug|Solubility" id="1552" />
-        <Map s="T1|Organism|Lumen|Duodenum|..|Paracellular absorption sink condition" id="1553" />
-        <Map s="T1|Organism|Lumen|Duodenum|pH" id="1554" />
-        <Map s="T1|Neighborhoods|Lumen_duo_Duodenum_cell|Drug|P_int_trans_cell_lum_factor" id="1555" />
-        <Map s="T1|Neighborhoods|Lumen_duo_Duodenum_cell|Drug|P_int_trans_lum_cell_factor" id="1556" />
-        <Map s="T1|Organism|Lumen|Duodenum|..|Transcellular absorption sink condition" id="1557" />
-        <Map s="T1|Neighborhoods|Duodenum_int_Duodenum_cell|Drug|Partition coefficient (intracellular/plasma)" id="1558" />
-        <Map s="T1|Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|pH" id="1559" />
-        <Map s="T1|Neighborhoods|Duodenum_pls_PortalVein_pls|Drug|Mass transfer rate (mucosa to portal vein plasma)" id="1560" />
-        <Map s="T1|Neighborhoods|Duodenum_bc_PortalVein_bc|Drug|Mass transfer rate (mucosa to portal vein blood cells)" id="1561" />
-        <Map s="T1|Organism|Lumen|ColonSigmoid|..|Paracellular absorption sink condition" id="1562" />
-        <Map s="T1|Neighborhoods|ColonSigmoid_bc_PortalVein_bc|Drug|Mass transfer rate (mucosa to portal vein blood cells)" id="1563" />
-        <Map s="T1|Drug|P_bc_pls_factor" id="1564" />
-        <Map s="P_rbc_pls_factor" id="1565" />
-        <Map s="T1|Organism|Vf (lipid, blood cells)" id="1566" />
-        <Map s="f_lipids_rbc" id="1567" />
-        <Map s="T1|Organism|Vf (protein,blood cells)" id="1568" />
-        <Map s="f_proteins_rbc" id="1569" />
-        <Map s="T1|Organism|Vf (water,blood cells)" id="1570" />
-        <Map s="f_water_rbc" id="1571" />
-        <Map s="T1|Drug|P_pls_bc_factor" id="1572" />
-        <Map s="P_pls_rbc_factor" id="1573" />
-        <Map s="T1|Drug|Specific intestinal permeability (transcellular)" id="1574" />
-        <Map s="P_int_InVitro" id="1575" />
-        <Map s="..|Is triprotic acid" id="1576" />
-        <Map s="IsTriproticAcid" id="1577" />
-        <Map s="..|pKa value 0" id="1578" />
-        <Map s="..|pKa value 1" id="1579" />
-        <Map s="..|pKa value 2" id="1580" />
-        <Map s="..|pKa_pH_WS_sol_F1" id="1581" />
-        <Map s="..|pKa_pH_WS_sol_F2" id="1582" />
-        <Map s="..|pKa_pH_WS_sol_F3" id="1583" />
-        <Map s="..|pKa_Acids_Count" id="1584" />
-        <Map s="pKa_Acids_Count" id="1585" />
-        <Map s="..|pKa_Bases_Count" id="1586" />
-        <Map s="pKa_Bases_Count" id="1587" />
-        <Map s="..|Compound type 0" id="1588" />
-        <Map s="CT_0" id="1589" />
-        <Map s="..|Compound type 1" id="1590" />
-        <Map s="CT_1" id="1591" />
-        <Map s="..|Compound type 2" id="1592" />
-        <Map s="CT_2" id="1593" />
-        <Map s="..|pKa_ThreeAcids_1" id="1594" />
-        <Map s="pKa_ThreeAcids_1" id="1595" />
-        <Map s="..|pKa_TwoAcids_1" id="1596" />
-        <Map s="pKa_TwoAcids_1" id="1597" />
-        <Map s="..|CT_ACID" id="1598" />
-        <Map s="CT_ACID" id="1599" />
-        <Map s="..|pKa_OneBase_0" id="1600" />
-        <Map s="pKa_OneBase_0" id="1601" />
-        <Map s="..|pKa_ThreeBases_0" id="1602" />
-        <Map s="pKa_ThreeBases_0" id="1603" />
-        <Map s="..|pKa_TwoBases_0" id="1604" />
-        <Map s="pKa_TwoBases_0" id="1605" />
-        <Map s="..|pKa_ThreeBases_1" id="1606" />
-        <Map s="pKa_ThreeBases_1" id="1607" />
-        <Map s="..|pKa_TwoBases_1" id="1608" />
-        <Map s="pKa_TwoBases_1" id="1609" />
-        <Map s="..|Is triprotic base" id="1610" />
-        <Map s="IsTriproticBase" id="1611" />
-        <Map s="..|CT_BASE" id="1612" />
-        <Map s="CT_BASE" id="1613" />
-        <Map s="..|CT_NEUTRAL" id="1614" />
-        <Map s="..|Reference pH" id="1615" />
-        <Map s="..|pKa_OneAcid_0" id="1616" />
-        <Map s="pKa_OneAcid_0" id="1617" />
-        <Map s="..|pKa_ThreeAcids_0" id="1618" />
-        <Map s="pKa_ThreeAcids_0" id="1619" />
-        <Map s="..|pKa_TwoAcids_0" id="1620" />
-        <Map s="pKa_TwoAcids_0" id="1621" />
-        <Map s="..|Br" id="1622" />
-        <Map s="Br" id="1623" />
-        <Map s="..|Cl" id="1624" />
-        <Map s="Cl" id="1625" />
-        <Map s="..|F" id="1626" />
-        <Map s="F" id="1627" />
-        <Map s="..|I" id="1628" />
-        <Map s="I" id="1629" />
-        <Map s="..|Molecular weight" id="1630" />
-        <Map s="Chlor" id="1631" />
-        <Map s="..|pKa_Acid_0" id="1632" />
-        <Map s="pKa_Acid_0" id="1633" />
-        <Map s="..|pKa_Acid_2" id="1634" />
-        <Map s="pKa_Acid_2" id="1635" />
-        <Map s="..|pKa_pH_WS_sol_K1" id="1636" />
-        <Map s="..|pKa_pH_WS_sol_K2" id="1637" />
-        <Map s="..|pKa_pH_WS_sol_K3" id="1638" />
-        <Map s="..|pKa_pH_WS_sol_K4" id="1639" />
-        <Map s="..|pKa_pH_WS_sol_K5" id="1640" />
-        <Map s="..|pKa_pH_WS_sol_K6" id="1641" />
-        <Map s="..|pKa_pH_WS_sol_K7" id="1642" />
-        <Map s="..|pKa_pH_WS_sol_K8" id="1643" />
-        <Map s="..|Solubility gain per charge" id="1644" />
-        <Map s="..|pKa_Base_0" id="1645" />
-        <Map s="pKa_Base_0" id="1646" />
-        <Map s="..|pKa_Base_2" id="1647" />
-        <Map s="pKa_Base_2" id="1648" />
-        <Map s="..|Effective molecular weight" id="1649" />
-        <Map s="MWEff" id="1650" />
-        <Map s="..|Is small molecule" id="1651" />
-        <Map s="IsSmallMolecule" id="1652" />
-        <Map s="..|Lipophilicity" id="1653" />
-        <Map s="..|Enzyme concentration" id="1654" />
-        <Map s="EnzymeConcentration" id="1655" />
-        <Map s="..|Specific clearance" id="1656" />
-        <Map s="CLspec" id="1657" />
-        <Map s="..|Fraction intracellular (liver)" id="1658" />
-        <Map s="..|Intrinsic clearance" id="1659" />
-        <Map s="CLInt" id="1660" />
-        <Map s="..|Volume (liver)" id="1661" />
-        <Map s="..|..|ProtocolSchemaItem|DrugMass" id="1662" />
-        <Map s="DrugMass" id="1663" />
-        <Map s="..|..|ProtocolSchemaItem|Amount of water" id="1664" />
-        <Map s="Water" id="1665" />
-        <Map s="..|ProtocolSchemaItem|Start time" id="1666" />
-        <Map s="StartTime" id="1667" />
-        <Map s="..|Dose" id="1668" />
-        <Map s="Dose" id="1669" />
-        <Map s="MassAmount" id="1670" />
-        <Map s="..|DosePerBodyWeight" id="1671" />
-        <Map s="DosePerBodyWeight" id="1672" />
-        <Map s="..|Volume of water/body weight" id="1673" />
-        <Map s="AmountOfWaterPerBodyWeight" id="1674" />
-        <Map s="VolumePerBodyWeight" id="1675" />
-        <Map s="..|ProtocolSchemaItem|DrugMass" id="1676" />
-        <Map s="..|simple|Application_1|ProtocolSchemaItem|DrugMass" id="1677" />
-        <Map s="M0" id="1678" />
-      </StringMap>
-    </FormulaCache>
-  </Model>
-  <FormulaCache>
-    <StringMap />
-  </FormulaCache>
-</ModelCoreSimulation>
\ No newline at end of file
diff --git a/tests/MoBi.Tests/TestFiles/Molecules.pkml b/tests/MoBi.Tests/TestFiles/Molecules.pkml
index 1cf2def7c..690655bda 100644
--- a/tests/MoBi.Tests/TestFiles/Molecules.pkml
+++ b/tests/MoBi.Tests/TestFiles/Molecules.pkml
@@ -1,200 +1,527 @@
 <?xml version="1.0" encoding="utf-8"?>
-<MoleculeBuildingBlock id="f438ddd6-38ff-41c0-a318-3793fa5c3271" name="Molecules" version="2">
+<MoleculeBuildingBlock id="n5ka-zq8l0qp9ffs1394KA" name="Molecules" icon="Molecule" bbVersion="0" version="13">
+  <Creation createdAt="5248846132857475618" createdBy="Michael" creationMode="New" origin="Other" />
   <Builders>
-    <MoleculeBuilder id="c3e84042-eb4e-4e70-9bca-cb5f51381017" name="Standard Molecule" icon="Drug" mode="Logical" containerType="Other" isFloating="1" quantityType="Drug" defaultStartFormula="730bc622-6fdb-4113-a1be-74479331b8bf">
+    <MoleculeBuilder id="Sw0MLPvOzkmA_VvS4P36PQ" name="Standard Molecule" icon="Drug" mode="Logical" containerType="Other" isFloating="1" quantityType="Drug" isXenobiotic="1" dim="Amount" defaultStartFormula="v4W_hJAbLky9Jzr07Esaiw" displayUnit="µmol">
       <Children>
-        <Parameter id="01ce2981-e50f-48f4-8b81-aae720d5fd32" name="pKa_Acids_Count" description="Number of acidic groups in compound" persistable="0" isFixedValue="0" formula="e5fba224-dd0b-48b9-b2b6-58320cdc413e" dim="Dimensionless" quantityType="0" buildMode="Property" visible="0" canBeVaried="0" />
-        <Parameter id="654e04cf-abe6-45bf-a5ff-4f4fbcd93ce6" name="pKa_pH_WS_sol_K2" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" formula="05f11b57-25ab-40a4-8d35-6c184f907478" dim="Dimensionless" quantityType="0" buildMode="Property" visible="0" canBeVaried="0" />
-        <Parameter id="db84e21f-2126-49d4-a8ee-ed4a8bc8ab43" name="Molecular weight" description="Molecular weight" persistable="0" isFixedValue="0" formula="618eef56-7722-4f75-965c-8d022a8c2a59" dim="MolecularWeight" quantityType="0" buildMode="Property" visible="1" canBeVaried="1" />
-        <Parameter id="500eaa0c-94a5-4540-93c1-273558b2770a" name="pKa value 0" description="pKa value" persistable="0" isFixedValue="0" formula="aba61122-eb22-4acf-bbbc-15a50afc6d10" dim="Dimensionless" quantityType="0" buildMode="Property" visible="1" canBeVaried="1" />
-        <Parameter id="0c4db0d9-7f09-45dc-84d9-d6133b9c1b95" name="pKa value 1" description="pKa value" persistable="0" isFixedValue="0" formula="b9593c99-6170-48ea-ad27-af5e154fceea" dim="Dimensionless" quantityType="0" buildMode="Property" visible="1" canBeVaried="1" />
-        <Parameter id="e651082f-32cf-4f81-956a-194c9925a99b" name="pKa value 2" description="pKa value" persistable="0" isFixedValue="0" formula="8ea3dd2b-2269-4ee3-8e68-82107cccfc16" dim="Dimensionless" quantityType="0" buildMode="Property" visible="1" canBeVaried="1" />
-        <Parameter id="7adab1bf-621e-45a9-ac74-ff3cef6627a2" name="pKa_Acid_0" description="Smallest acid pKa" persistable="0" isFixedValue="0" formula="4426ebce-4576-4306-ba26-9276ce85e1fc" dim="Dimensionless" quantityType="0" buildMode="Property" visible="0" canBeVaried="0" />
-        <Parameter id="68c87d8c-2b31-465b-8cd8-ced43ca1e440" name="Is triprotic acid" description="Is triprotic acid" persistable="0" isFixedValue="0" formula="23604d2d-cb66-4134-92a0-efd2f8824bf3" dim="Dimensionless" quantityType="0" buildMode="Property" visible="0" canBeVaried="0" />
-        <Parameter id="ebc5e3af-2c1d-4dbc-a922-804144a3fc1c" name="pKa_Acid_2" description="Largest acid pKa" persistable="0" isFixedValue="0" formula="ccba3f94-63e1-4602-abb7-72324672e8ca" dim="Dimensionless" quantityType="0" buildMode="Property" visible="0" canBeVaried="0" />
-        <Parameter id="9600108f-146b-4211-8673-5e4376f6056f" name="Is strong base" description="Supporting parameter for partition coeffs in RR-Modell (at least one basic pKa&gt;=7)" persistable="0" isFixedValue="0" formula="40627d66-82e6-45aa-b770-43173bac6f11" dim="Dimensionless" quantityType="0" buildMode="Property" visible="0" canBeVaried="0" />
-        <Parameter id="f9aa4e17-ee4f-48e5-8735-580ad47b6105" name="pKa_Base_0" description="Smallest base pKa" persistable="0" isFixedValue="0" formula="f08e67b2-3f0f-499e-b30d-e4d0ae2dba59" dim="Dimensionless" quantityType="0" buildMode="Property" visible="0" canBeVaried="0" />
-        <Parameter id="f4ce31e2-6d83-41d0-94a8-74ba0e8cc973" name="pKa_Base_1" description="Middle base pKa" persistable="0" isFixedValue="0" formula="4f957f35-6e5f-4207-9f13-3af45171ac94" dim="Dimensionless" quantityType="0" buildMode="Property" visible="0" canBeVaried="0" />
-        <Parameter id="f58b1d7b-769e-456b-a298-58eca6aa39f8" name="pKa_Base_2" description="Largest base pKa" persistable="0" isFixedValue="0" formula="588827f7-e29d-4247-961c-686244ab7ec6" dim="Dimensionless" quantityType="0" buildMode="Property" visible="0" canBeVaried="0" />
-        <Parameter id="5319bb7f-8f0b-41b8-b1cf-3ad5387b4164" name="pKa_Bases_Count" description="Number of basic groups in compound" persistable="0" isFixedValue="0" formula="4bfaaf73-ce9c-405c-81d1-d5eaeb3ac7e2" dim="Dimensionless" quantityType="0" buildMode="Property" visible="0" canBeVaried="0" />
-        <Parameter id="903eca32-9797-4062-a938-ed5373190860" name="pKa_OneAcid_0" description="Smallest acid pKa for compound with 1 acid group" persistable="0" isFixedValue="0" formula="1ba98e86-dddb-4885-9445-62c22b2cac45" dim="Dimensionless" quantityType="0" buildMode="Property" visible="0" canBeVaried="0" />
-        <Parameter id="02d88bfa-e6ca-4364-921e-0f989552ea9a" name="pKa_OneBase_0" description="Smallest base pKa for compound with 1 base group" persistable="0" isFixedValue="0" formula="603773bf-5e5c-4257-9a53-f1ad8cf91850" dim="Dimensionless" quantityType="0" buildMode="Property" visible="0" canBeVaried="0" />
-        <Parameter id="31f0154e-58fd-4e1a-b414-2f36519ed770" name="pKa_pH_WS_sol_F1" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" formula="c7869dc9-aeea-4dc8-951e-38db528f4222" dim="Dimensionless" quantityType="0" buildMode="Property" visible="0" canBeVaried="0" />
-        <Parameter id="185fbe27-a43c-4082-b3c0-33c33a1f4fcc" name="pKa_pH_WS_sol_F2" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" formula="592d062d-25e4-4383-bffc-0d8e70095d89" dim="Dimensionless" quantityType="0" buildMode="Property" visible="0" canBeVaried="0" />
-        <Parameter id="d3551279-55d1-4f3c-999a-7eca8a026337" name="pKa_pH_WS_sol_F3" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" formula="5a89c8e5-9d1c-48bb-afd9-0a39b820c330" dim="Dimensionless" quantityType="0" buildMode="Property" visible="0" canBeVaried="0" />
-        <Parameter id="34295e39-c646-43e8-8817-47c38899db22" name="pKa_Acid_1" description="Middle acid pKa" persistable="0" isFixedValue="0" formula="13adb5a3-ebe2-47ee-ad79-d6d3b4caecd7" dim="Dimensionless" quantityType="0" buildMode="Property" visible="0" canBeVaried="0" />
-        <Parameter id="a5110495-bf14-4c0a-93ea-5591baf6a42f" name="Compound type 2" description="Compound type (-1: acid, +1: base, 0: neutral)" persistable="0" isFixedValue="0" formula="d7f1091c-e77b-4fe0-9338-a15e0c445b4d" dim="Dimensionless" quantityType="0" buildMode="Property" visible="1" canBeVaried="0" />
-        <Parameter id="48226e61-7c6c-4cdd-8c4f-e1b68a273e5a" name="CT_ACID" description="Constant for compound type acid" persistable="0" isFixedValue="0" formula="147990d4-a6ad-433e-82d2-1660c1ce01d4" dim="Dimensionless" quantityType="0" buildMode="Property" visible="0" canBeVaried="0" />
-        <Parameter id="936afab9-a563-4956-8ac4-93e038e68778" name="CT_BASE" description="Constant for compound type base" persistable="0" isFixedValue="0" formula="a2ae4fcd-4eed-4f6f-b1e7-e6582de15cb5" dim="Dimensionless" quantityType="0" buildMode="Property" visible="0" canBeVaried="0" />
-        <Parameter id="27000530-74d7-4ae7-9a14-82d0c5179022" name="CT_NEUTRAL" description="Constant for compound type neutral" persistable="0" isFixedValue="0" formula="aadd817c-094a-4cfb-851e-970a7ca898c5" dim="Dimensionless" quantityType="0" buildMode="Property" visible="0" canBeVaried="0" />
-        <Parameter id="dda729b6-9f5a-4c26-93eb-64dba8f78a62" name="Effective molecular weight" description="Effective molecular weight" persistable="0" isFixedValue="0" formula="3dfa88c0-e274-4976-8510-e80070e6cbc9" dim="MolecularWeight" quantityType="0" buildMode="Property" visible="1" canBeVaried="1" />
-        <Parameter id="97841512-4d22-4d10-a4bf-95a129b3490d" name="F" description="Number of fluorine atoms in molecule" persistable="0" isFixedValue="0" formula="e264fd18-e374-40a3-bc28-1984ed5ff212" dim="Dimensionless" quantityType="0" buildMode="Property" visible="1" canBeVaried="0" />
-        <Parameter id="5dabcd69-cba1-4d1a-ae99-0708c243d7b1" name="Is triprotic base" description="Is triprotic base" persistable="0" isFixedValue="0" formula="f9717cac-a14a-47a3-94e2-8a54145ed3f3" dim="Dimensionless" quantityType="0" buildMode="Property" visible="0" canBeVaried="0" />
-        <Parameter id="03fd7b84-f0f6-49a2-b684-fbfb2c1208e7" name="I" description="Number of iodine atoms in molecule" persistable="0" isFixedValue="0" formula="521446e0-b2c6-4375-9915-5da47993b1e6" dim="Dimensionless" quantityType="0" buildMode="Property" visible="1" canBeVaried="0" />
-        <Parameter id="3a1f77c0-3182-44d9-8893-5a3fc7a04f9a" name="pKa_pH_WS_sol_K3" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" formula="00905a5c-afb6-49b3-af8a-d699d3f35392" dim="Dimensionless" quantityType="0" buildMode="Property" visible="0" canBeVaried="0" />
-        <Parameter id="91649095-e78e-4a50-ae8a-3abd39b740a7" name="Is diprotic acid" description="Is diprotic acid" persistable="0" isFixedValue="0" formula="fe011bb9-63bf-4abe-982c-67e714eb9ef2" dim="Dimensionless" quantityType="0" buildMode="Property" visible="0" canBeVaried="0" />
-        <Parameter id="f3e7ec8f-f5e8-4cfd-a53a-77aac74554b9" name="Is diprotic base" description="Is diprotic base" persistable="0" isFixedValue="0" formula="c2f2c8b1-45e2-4467-9ada-a60d8f8b83dc" dim="Dimensionless" quantityType="0" buildMode="Property" visible="0" canBeVaried="0" />
-        <Parameter id="3a9c28af-08a5-43f3-b132-36f273b635d8" name="Is diprotic base monoprotic acid" description="Is diprotic base monoprotic acid" persistable="0" isFixedValue="0" formula="780e828f-b5ee-49fb-9602-df08118794c7" dim="Dimensionless" quantityType="0" buildMode="Property" visible="0" canBeVaried="0" />
-        <Parameter id="15810a1d-5d72-4836-a0f1-0ee547c7252d" name="Is floating in lumen" description="Is floating in lumen" persistable="0" isFixedValue="0" formula="37466c4f-aab5-4555-b551-e396eecef155" dim="Dimensionless" quantityType="0" buildMode="Property" visible="0" canBeVaried="0" />
-        <Parameter id="a017f799-c3d8-4589-8ebd-9d797a344ff9" name="Is monoprotic acid" description="Is monoprotic acid" persistable="0" isFixedValue="0" formula="1ffe8919-ce6b-4d1b-ad0f-025c20b9c1a1" dim="Dimensionless" quantityType="0" buildMode="Property" visible="0" canBeVaried="0" />
-        <Parameter id="e57ae45c-f961-46b7-bec8-1887377f8660" name="Is monoprotic base" description="Is monoprotic base" persistable="0" isFixedValue="0" formula="261c8b1d-4a70-4e5d-8c50-26da11a8ae53" dim="Dimensionless" quantityType="0" buildMode="Property" visible="0" canBeVaried="0" />
-        <Parameter id="2e70f6ec-ab5f-44ea-9c08-7ab175586721" name="Is monoprotic base diprotic acid" description="Is monoprotic base diprotic acid" persistable="0" isFixedValue="0" formula="f807db4d-d64b-471b-9bf1-d0b47f08aa73" dim="Dimensionless" quantityType="0" buildMode="Property" visible="0" canBeVaried="0" />
-        <Parameter id="bbc76b89-d0e1-4522-9a82-4e237e983a48" name="Is monoprotic base monoprotic acid" description="Is monoprotic base monoprotic acid" persistable="0" isFixedValue="0" formula="d747cc1c-f2fc-4731-adb1-99f28358d033" dim="Dimensionless" quantityType="0" buildMode="Property" visible="0" canBeVaried="0" />
-        <Parameter id="e07b973a-7f78-45fd-925a-00f553d6abf7" name="Is neutral" description="Supporting parameter for partition coeffs in RR-Modell" persistable="0" isFixedValue="0" formula="b72804f9-2ec0-46d1-bfb9-b25c304bf709" dim="Dimensionless" quantityType="0" buildMode="Property" visible="0" canBeVaried="0" />
-        <Parameter id="2252670d-efbf-433b-8d72-0bff5fcc20ea" name="Is small molecule" description="Treat compound as small molecule or not (if not, both organ specific and intestinal permeability will be set to zero)" persistable="0" isFixedValue="0" formula="a197b9b3-776f-46ad-89d0-696bc00e08ea" dim="Dimensionless" quantityType="0" buildMode="Property" visible="0" canBeVaried="0" />
-        <Parameter id="5bd5bc48-372d-4820-9cfb-e9d09b290318" name="Has halogens" description="Supporting parameter for compound" persistable="0" isFixedValue="0" formula="d89cc30f-f8cd-4044-93f2-25b9cf93f6e9" dim="Dimensionless" quantityType="0" buildMode="Property" visible="0" canBeVaried="0" />
-        <Parameter id="61bbf1c8-08fa-47ce-8616-e660e80dea65" name="pKa_pH_WS_sol_K1" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" formula="ae8fe106-e589-490e-9b19-025db8e6f438" dim="Dimensionless" quantityType="0" buildMode="Property" visible="0" canBeVaried="0" />
-        <Parameter id="936eb91b-cd57-485d-becd-115365402647" name="pKa_TwoBases_0" description="Smallest base pKa for compound with 2 base groups" persistable="0" isFixedValue="0" formula="cd365569-a477-4848-b37a-f2c2a1ba1bcb" dim="Dimensionless" quantityType="0" buildMode="Property" visible="0" canBeVaried="0" />
-        <Parameter id="65fc36b4-f06e-494b-a249-78868664093d" name="pKa_pH_WS_sol_K4" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" formula="391179c8-77e7-4376-ab6e-a24155a46d5c" dim="Dimensionless" quantityType="0" buildMode="Property" visible="0" canBeVaried="0" />
-        <Parameter id="9fcc7b61-f2fc-47af-8bcb-6b2d978e77cc" name="pKa_pH_WS_sol_K5" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" formula="804656e6-b3ae-4d1a-9bca-1a4527484336" dim="Dimensionless" quantityType="0" buildMode="Property" visible="0" canBeVaried="0" />
-        <Parameter id="583e6c19-fbd2-4e23-a65a-865b131377cc" name="pKa_pH_WS_sol_K6" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" formula="77405460-ed39-481b-9f55-1857229242d0" dim="Dimensionless" quantityType="0" buildMode="Property" visible="0" canBeVaried="0" />
-        <Parameter id="15879acc-7fd2-4a3c-aeaa-d2135b32bc85" name="pKa_pH_WS_sol_K7" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" formula="402da265-25d6-4416-9d3a-4001088a3061" dim="Dimensionless" quantityType="0" buildMode="Property" visible="0" canBeVaried="0" />
-        <Parameter id="50890cf6-9af6-478f-8fb4-8906844bfc69" name="pKa_pH_WS_sol_K8" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" persistable="0" isFixedValue="0" formula="bb5c8e0e-95bb-4bc3-a233-ae80c72d802c" dim="Dimensionless" quantityType="0" buildMode="Property" visible="0" canBeVaried="0" />
-        <Parameter id="bb7afd7a-f528-4d3b-9e1e-528a24bed85d" name="pKa_ThreeAcids_0" description="Smallest acid pKa for compound with 3 acid groups" persistable="0" isFixedValue="0" formula="cbd3e432-f7c0-4c31-894d-42ea90630201" dim="Dimensionless" quantityType="0" buildMode="Property" visible="0" canBeVaried="0" />
-        <Parameter id="e7347654-2834-4517-9a5a-c5f6bf10e99d" name="pKa_ThreeAcids_1" description="Middle acid pKa for compound with 3 acid groups" persistable="0" isFixedValue="0" formula="fa37f31b-967f-45d2-a76b-0eeecdba84fb" dim="Dimensionless" quantityType="0" buildMode="Property" visible="0" canBeVaried="0" />
-        <Parameter id="5ddc8fe4-7cab-4b12-bbff-804d49b83b8b" name="pKa_ThreeBases_0" description="Smallest base pKa for compound with 3 base groups" persistable="0" isFixedValue="0" formula="9bdded95-3c75-4628-b649-6fdf54dfd41f" dim="Dimensionless" quantityType="0" buildMode="Property" visible="0" canBeVaried="0" />
-        <Parameter id="fafeacae-3f4b-4293-90da-943a8ecd9f00" name="pKa_ThreeBases_1" description="Middle base pKa for compound with 3 base groups" persistable="0" isFixedValue="0" formula="f1efd166-55bf-45b7-8a54-2583b96c8cca" dim="Dimensionless" quantityType="0" buildMode="Property" visible="0" canBeVaried="0" />
-        <Parameter id="594bfeb1-15c2-4e6a-950f-6a4e841a890b" name="pKa_TwoAcids_1" description="Middle acid pKa for compound with 2 acid groups" persistable="0" isFixedValue="0" formula="9f4eacd5-1fda-4a28-81b5-0c1cc676f6ff" dim="Dimensionless" quantityType="0" buildMode="Property" visible="0" canBeVaried="0" />
-        <Parameter id="9a938222-566d-4e51-9cae-9db8520431a8" name="pKa_TwoBases_1" description="Middle base pKa for compound with 2 base groups" persistable="0" isFixedValue="0" formula="8ac9f732-b720-44b7-b2d4-86e24cbf2a2b" dim="Dimensionless" quantityType="0" buildMode="Property" visible="0" canBeVaried="0" />
-        <Parameter id="477f0c31-91d0-4a4b-9a70-2187fe310c03" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" persistable="0" isFixedValue="0" formula="1d7f0e1b-a6aa-43ab-91b8-ffa0f43fa938" dim="Dimensionless" quantityType="0" buildMode="Property" visible="0" canBeVaried="0" />
-        <Parameter id="14b019ed-5513-4c48-af86-20c6fc015128" name="Total oral drug mass" description="Total oral drug mass" persistable="0" isFixedValue="0" formula="724e229b-dd56-4945-ad5e-5cd2a340e492" dim="Amount" quantityType="0" buildMode="Property" visible="0" canBeVaried="0" />
-        <Parameter id="7b12b381-21ab-4c05-a1d3-7c6f9e0adae8" name="pKa_TwoAcids_0" description="Smallest acid pKa for compound with 2 acid groups" persistable="0" isFixedValue="0" formula="fb4dc464-9921-4d36-95f5-087bf530204e" dim="Dimensionless" quantityType="0" buildMode="Property" visible="0" canBeVaried="0" />
-        <Parameter id="91672c6c-499e-494a-a197-00fce82f986b" name="Compound type 0" description="Compound type (-1: acid, +1: base, 0: neutral)" persistable="0" isFixedValue="0" formula="21eea311-5783-49f3-bd2a-7ddcafa488f4" dim="Dimensionless" quantityType="0" buildMode="Property" visible="1" canBeVaried="0" />
-        <Parameter id="176fb2b4-3771-4a83-a94e-d2f9aa8f783c" name="Cl" description="Number of chlorine atoms in molecule" persistable="0" isFixedValue="0" formula="9f2a9f1a-0f43-489d-84e8-cea53bfbe65c" dim="Dimensionless" quantityType="0" buildMode="Property" visible="1" canBeVaried="0" />
-        <Parameter id="a3b55c80-bcd9-406b-8a8f-663f46ab6a4d" name="Compound type 1" description="Compound type (-1: acid, +1: base, 0: neutral)" persistable="0" isFixedValue="0" formula="4bee111b-6310-432d-b1e1-ae79dfec0ec1" dim="Dimensionless" quantityType="0" buildMode="Property" visible="1" canBeVaried="0" />
-        <Parameter id="960b3308-1579-4be4-9010-1c889b916aea" name="base_For_KaPL_Factor" description="Supporting parameter for calculation of pKa- and pH- dependent values of KaPL" persistable="0" isFixedValue="0" formula="0ee8360a-3ba3-4a42-a7e1-07934cabad9f" dim="Dimensionless" quantityType="0" buildMode="Property" visible="0" canBeVaried="0" />
-        <Parameter id="226e2a96-56a1-4a6c-bd61-471fa4c0b7ae" name="base_For_logD_Factor" description="Supporting parameter for calculation of pKa- and pH- dependent logD" persistable="0" isFixedValue="0" formula="d6efbfab-0198-47a9-90c2-529ea9004292" dim="Dimensionless" quantityType="0" buildMode="Property" visible="0" canBeVaried="0" />
-        <Parameter id="e91894cf-97d8-41e7-b424-edacca752ab1" name="base_For_P_cell_Factor" description="Supporting parameter for calculation of pKa- and pH- dependent permeability to/from cells" persistable="0" isFixedValue="0" formula="b0f1f832-4cd7-40a7-a5d0-a89eae4b7d82" dim="Dimensionless" quantityType="0" buildMode="Property" visible="0" canBeVaried="0" />
-        <Parameter id="6ec6dd77-9991-432f-8c92-bef66068da39" name="base_For_Pint_Factor" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="f0ebb3e5-3a68-41ad-a5d4-e1e2a39d60be" dim="Dimensionless" quantityType="0" buildMode="Property" visible="0" canBeVaried="0" />
-        <Parameter id="2ba3b5a5-f343-43b9-9827-8b7dc3b1fe90" name="Br" description="Number of bromine atoms in molecule" persistable="0" isFixedValue="0" formula="0fb0d6d8-d1a8-4165-a6ab-241525e2fd43" dim="Dimensionless" quantityType="0" buildMode="Property" visible="1" canBeVaried="0" />
-        <Parameter id="394d13a4-cce1-40bd-85eb-1eb92deb584d" name="Lipophilicity" description="Model dependent lipophilicity measure: LogMA / LogP / ..." persistable="0" isFixedValue="0" formula="9b164e8f-d30d-4662-b8c1-3af37bfaa6f9" dim="Lipophilicity" quantityType="0" buildMode="Property" visible="1" canBeVaried="1" />
-        <Parameter id="17d37da5-2903-47db-a69d-3c023e71fa64" name="Fraction unbound (plasma)" description="Fraction unbound in plasma" persistable="0" isFixedValue="0" formula="19c0252d-bfc6-44e2-9a99-6e2f515f5aba" dim="Fraction" quantityType="0" buildMode="Property" visible="1" canBeVaried="1" />
-        <Parameter id="259e9a05-ccd3-4e99-837d-e4fca7c14f99" name="Solubility at reference pH" description="Solubility at reference pH" persistable="0" isFixedValue="0" formula="68c0d685-8d53-45db-b8d9-c50fdf78251f" dim="Concentration" quantityType="0" buildMode="Property" visible="1" canBeVaried="1" />
-        <Parameter id="87cad6ae-95cf-4894-a8a2-35431fa4a7f8" name="Reference pH" description="Reference pH" persistable="0" isFixedValue="0" formula="ccaea30a-61a3-497e-a44e-20d380b63b83" dim="Dimensionless" quantityType="0" buildMode="Property" visible="1" canBeVaried="1" />
-        <Parameter id="dc83a069-bf28-401a-91d3-22c5ca1344a7" name="Solubility gain per charge" description="Supporting parameter for calculation of pKa- and pH- dependent values of intestinal solubilty" persistable="0" isFixedValue="0" formula="a0a16c90-9702-4c12-bd15-0ffe67c68b8a" dim="Dimensionless" quantityType="0" buildMode="Property" visible="1" canBeVaried="0" />
-        <Parameter id="f3e51c6d-57af-42bd-9372-c9888bb604bb" name="Permeability" description="Permeability" persistable="0" isFixedValue="0" formula="95ea7e0e-7821-4825-9019-549a4a893785" dim="Velocity" quantityType="0" buildMode="Property" visible="1" canBeVaried="1" />
-        <Parameter id="de9b5c40-bb51-4634-8046-66c3980e5faf" name="Specific intestinal permeability (transcellular)" description="Specific intestinal permeability (transcellular)" persistable="0" isFixedValue="0" formula="2e21b031-4150-413c-8bfe-428d023baf36" dim="Velocity" quantityType="0" buildMode="Property" visible="1" canBeVaried="1" />
-        <Parameter id="319bc9e0-ec1a-4af7-b3d1-79a56f55d8f7" name="Partition coefficient (water/protein)" description="Partition coefficient water to protein" persistable="0" isFixedValue="0" formula="560afe24-0801-4366-90e5-6a213de72ffd" dim="Dimensionless" quantityType="0" buildMode="Property" visible="1" canBeVaried="1" />
-        <Parameter id="fdcc86c8-a27f-455c-ad59-3cdfd37d05df" name="Treat precipitated drug as" description="Treat precipitated drug as either soluble or insoluble" persistable="0" isFixedValue="0" formula="144daa8f-c630-4b32-822a-44e7693f7135" dim="Dimensionless" quantityType="0" buildMode="Property" visible="1" canBeVaried="1" />
-        <Parameter id="3a934922-f698-4d4a-98ed-5599b4c00b8d" name="Aqueous diffusion coefficient" description="Aqueous diffusion coefficient&#xA;of the drug" persistable="0" isFixedValue="0" formula="ecf1d1dd-0642-4c4a-821d-46f238cc8c73" dim="DiffusionCoefficient" quantityType="0" buildMode="Property" visible="1" canBeVaried="1" />
-        <Parameter id="0392b441-ca7f-449d-8f6c-ee3e15803772" name="Density (drug)" description="Density of drug material" persistable="0" isFixedValue="0" formula="a6006406-3d70-409f-8e4f-6e4752f59efa" dim="Density" quantityType="0" buildMode="Property" visible="1" canBeVaried="1" />
-        <Parameter id="a1e3da02-b9e3-4621-bc4c-4d3d0ca8ef7f" name="Immediately dissolve particles smaller than" description="Threshold for the particle radius of immediate dissolution" persistable="0" isFixedValue="0" formula="dc3cde42-2729-4533-9a0a-e7e08f63ea0c" dim="Nanolength" quantityType="0" buildMode="Property" visible="1" canBeVaried="1" />
-        <Parameter id="9f0ea4c2-58b7-4f60-9d6c-760ce930fe1f" name="Radius (solute)" description="Solute radius" persistable="0" isFixedValue="0" formula="9afe72f6-8ce0-430b-981c-6281f680de9f" dim="Nanolength" quantityType="0" buildMode="Property" visible="1" canBeVaried="1" />
-        <Parameter id="5b0dd5e5-e9c2-441b-a46a-069d22bd1336" name="Kd (FcRn)" description="Dissociation constant for binding of drug to FcRn" persistable="0" isFixedValue="0" formula="032f5c87-ac58-4a59-bae7-151c650eaff2" dim="MolarConcentration" quantityType="0" buildMode="Property" visible="1" canBeVaried="1" />
-        <Parameter id="97de7fb9-46a3-49b3-9f70-17bb961ed182" name="Use pH- and pKa-dependent penalty factor for charged molecule fraction" description="Penalty factor for charged molecule fraction is used for &quot;Intestinal permeability (transcellular)&quot; only" persistable="0" isFixedValue="0" formula="8b7c4adc-a4b0-4306-be2d-387331cff826" dim="Dimensionless" quantityType="0" buildMode="Property" visible="1" canBeVaried="1" />
-        <Parameter id="57eff736-2503-427b-bd96-8bdb3eec66bb" name="Concentration" persistable="0" isFixedValue="0" formula="e1406baf-c159-4aba-92f0-080bc51c5a56" dim="MolarConcentration" quantityType="0" visible="0" canBeVaried="0" />
-        <TransporterMoleculeContainer id="c5f7deec-12f3-4f36-a120-d9af8c029db0" name="PGP" transportName="PGP">
-          <ActiveTransportRealizations>
-            <TransportBuilder id="f7d942f4-eaeb-4658-ad45-1cc98cde1e29" name="Like" dimension="Dimensionless" createProcessRateParameter="0" formula="a4bf0961-d8d6-4e96-9654-79991ec47f31" transportType="0">
+        <Parameter id="ZK7dbcNYBEq37LDq9_ZMWQ" name="pKa_Acids_Count" description="Number of acidic groups in compound" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="hVFHSgq4mE2pr2wDGly2Kg" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="qRMzKEkXtUiEnW8qRmefIA" name="pKa_pH_WS_sol_K2" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Szzn0TV2zUq4rihK7WPHOA" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="lUsowY_b_kqUw3WmPTUePQ" name="Molecular weight" description="Molecular weight" icon="Parameter" persistable="0" isFixedValue="0" dim="Molecular weight" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="4E-07" displayUnit="g/mol">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="o9bIIhMzb0mwYr5bH_cRpA" name="pKa value 0" description="pKa value" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="TXCDJZf_1kuiGZb1FH8L0g" name="pKa value 1" description="pKa value" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="VWXMt_kXfkCsQqbgSqx2_w" name="pKa value 2" description="pKa value" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="OT-EQ4XiMUODXXqqBkSFfQ" name="pKa_Acid_0" description="Smallest acid pKa" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="oPf_Gv2bXUWOWAE-AmELkw" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="vqc_S9nfU0Sf57WfzTezZQ" name="Is triprotic acid" description="Is triprotic acid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_EL9ispm0kO1wy6gAxVXkg" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="EB7CqGl7Y0iLQJTpMad-Yw" name="pKa_Acid_2" description="Largest acid pKa" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="SVyCFbx1XkyyzC6_Zssh-w" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="uc8ILuWuk0ixCsshQDcL2g" name="Is strong base" description="Supporting parameter for partition coeffs in RR-Modell (at least one basic pKa&gt;=7)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="gxXfWQ5WI0-5Mp5-aksjqg" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="Yrf_nykThEK-a8rBSQcURw" name="pKa_Base_0" description="Smallest base pKa" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BU5bAzzxxE2iG6SFmmTDBQ" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="VhoTU3uaJ0COBBxhhgkYgA" name="pKa_Base_1" description="Middle base pKa" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="M8KJNlRsPUO_m1iltcp6MA" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="g2_Kl7tyQkKZcScgp5CSgw" name="pKa_Base_2" description="Largest base pKa" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="5VjEtnaMVkaxMtRdxgTnvw" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="nSVnNJXYJ0qYqcGFyRgaaA" name="pKa_Bases_Count" description="Number of basic groups in compound" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="qnQGGHj5N0yYwVLR28J0Jg" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="_sY9Xc7zyUSs2TmyYF-KNg" name="pKa_OneAcid_0" description="Smallest acid pKa for compound with 1 acid group" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="HRwuurQc1EaA7ncM4pJB1w" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="SlVjmFkdoU-zlN3CoMUXPQ" name="pKa_OneBase_0" description="Smallest base pKa for compound with 1 base group" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="VgrdscGuxkWoruk0VqGODQ" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="jyfmnEKP9k-tC1-SMQDD8w" name="pKa_pH_WS_sol_F1" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="0Wd2c452xki5zWpUUc_OWw" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="hgHVrc4no0Gos1hCQRR0xA" name="pKa_pH_WS_sol_F2" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="nqxOK6X-ykiHoJUQoY5xHw" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="a9u0EV0TAUe8A2YMBo1gUg" name="pKa_pH_WS_sol_F3" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ISS_B9d4N0aKX_Zb6w1qmA" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="2--SV4Ez00me2jI-2aJnRA" name="pKa_Acid_1" description="Middle acid pKa" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="WW5qavloYE-lujFoLxCkaA" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="fcMMuVV7B0qpeKfYiif37w" name="Compound type 2" description="Compound type (-1: acid, +1: base, 0: neutral)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="2RA6E8CNA0m4f3wJDOrUQA" name="CT_ACID" description="Constant for compound type acid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="-1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="pc73iPFW2EmZTo-F8CUV3w" name="CT_BASE" description="Constant for compound type base" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="GZnqrTbVUEmVJGfMT5SgDg" name="CT_NEUTRAL" description="Constant for compound type neutral" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="6HuzS8irnUi66Ou-yHkNwQ" name="Effective molecular weight" description="Effective molecular weight" icon="Parameter" persistable="0" isFixedValue="0" dim="Molecular weight" quantityType="Parameter" negativeValuesAllowed="1" formula="R4B76J5_xES-bwD0V4-Eaw" buildMode="Property" isDefault="1" displayUnit="g/mol">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="C4nLfKGiNEisnfvxaNZWwQ" name="F" description="Number of fluorine atoms in molecule" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="tdaRE3gly0yXH_37QBYFQw" name="Is triprotic base" description="Is triprotic base" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="sqs0VyfLeUC2NcI0TsI-jg" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="YLYIS7f9K0Kj1-YdTySZOw" name="I" description="Number of iodine atoms in molecule" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="TOaRwbs0YUinfrwe7oS8Fw" name="pKa_pH_WS_sol_K3" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CrwUJZDPdkuxvUw3_MfYvg" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="BLXkA86NSEueVgtsKrERUg" name="Is diprotic acid" description="Is diprotic acid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="-lEpazMaXECL2cECmijO5w" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="93HvR9TAnkiIOIG5RYYylA" name="Is diprotic base" description="Is diprotic base" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="z88_2ktlt0WYVR3zNrEI4w" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="2uRIaK5MmUW1fHW23IjJ8w" name="Is diprotic base monoprotic acid" description="Is diprotic base monoprotic acid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="2kAuN4ISc0mmzBpjfE5exQ" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="Xcq5Ps4cskK4FTwC9RYllA" name="Is floating in lumen" description="Is floating in lumen" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="0FS7jb1T8UCM35aLuDp_lA" name="Is monoprotic acid" description="Is monoprotic acid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="NPqclKDUXEu43HxlSghvTw" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="8uQg-JFHwkeYISqhdLW4zQ" name="Is monoprotic base" description="Is monoprotic base" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="pEu5n_jVkUmnFyat9x1pOA" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="ZwIepSk1TUWllGR8NyHKXw" name="Is monoprotic base diprotic acid" description="Is monoprotic base diprotic acid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="McjQLaQlbUStSYVN89VisA" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="Psu9Bk5RIkaVbPgk1pWqPg" name="Is monoprotic base monoprotic acid" description="Is monoprotic base monoprotic acid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="D3sGK2m-wkmY4S9HAXQqDQ" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="hF8iQ8Kk8Um_OGws4GW1Cg" name="Is neutral" description="Supporting parameter for partition coeffs in RR-Modell" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="t9A3_RncCEe-6VsJzVVDRw" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="zxIeJ58YDEeNVOVkvzbwAQ" name="Is small molecule" description="Treat compound as small molecule or not (if not, both organ specific and intestinal permeability will be set to zero)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="yNUF8-KVw0-CXdxHpQO1_g" name="Has halogens" description="Supporting parameter for compound" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="UgC4FkZ8bUy4VRgrXxBRdg" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="PgBpY7d6JUe5uVUC7am09A" name="pKa_pH_WS_sol_K1" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="dY2_MKkdT0mL-wNbBJB2bw" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="Q2xvm9q3hkO0srg6LdTyJg" name="pKa_TwoBases_0" description="Smallest base pKa for compound with 2 base groups" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="f7AVAt7mVUezoHQiNVw1iw" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="AzizDSh1EUeqNcsLotAC9Q" name="pKa_pH_WS_sol_K4" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ebR5s5oYGk2nhp7Iotfttw" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="uueqHGS8QUeaCc7OAzbbtQ" name="pKa_pH_WS_sol_K5" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="K6Oz-wT3WEuZcxbCaxXV7g" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="kDgAEGqiqU-z0msoMEP2bQ" name="pKa_pH_WS_sol_K6" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="q19OAc-2IEitwwqwqisjJA" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="3zSa3J6KCUi6eTB6EAytgQ" name="pKa_pH_WS_sol_K7" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="J-GLHfhTdkaWVR-lyMnR3g" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="8EbNbrsnmkqIGNGhwmcYZg" name="pKa_pH_WS_sol_K8" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="78-kbB0qc0CtHWLIQiWMnA" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="1Z6FTfhI8EqRAdrOA8D0LA" name="pKa_ThreeAcids_0" description="Smallest acid pKa for compound with 3 acid groups" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="vHT9x5jzPEm5GXz_0oOFYQ" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="1z0_YRXbyE6oB7oAeq0Gtg" name="pKa_ThreeAcids_1" description="Middle acid pKa for compound with 3 acid groups" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="v4oEcuuGzEC4KPs1famoqw" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="vZsq1Y-xxU6N54S4eDQbcw" name="pKa_ThreeBases_0" description="Smallest base pKa for compound with 3 base groups" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="RPrfJEOyd0u4CcBIIb2hEA" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="ha5ooOWny0eDcKUZIDvYMQ" name="pKa_ThreeBases_1" description="Middle base pKa for compound with 3 base groups" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Q-1Sy1dGj0qhtdiBpiCSvw" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="RhZTPZ2qaEOIZnzvxbFGSQ" name="pKa_TwoAcids_1" description="Middle acid pKa for compound with 2 acid groups" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="k4dwYQRYEEGdYiS5bqzvQA" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="R3S46ldB1UqoKePiX0g5lw" name="pKa_TwoBases_1" description="Middle base pKa for compound with 2 base groups" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="8uBCH8bTCkWgOgtPqEqf7A" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="DVwoM3nXHk-3g-OXvKkN8w" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="hl_xHXhJFE2Adq6jBGTSpA" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="zVgfPjERMUumHuAa41wMVQ" name="Total oral drug mass" description="Total oral drug mass" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0" displayUnit="µmol">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="6dtcdR3FcUeCP0CnwOOXmA" name="pKa_TwoAcids_0" description="Smallest acid pKa for compound with 2 acid groups" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="2xsDcah1h0iQ7F5tc_jRlA" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="cZSz4gKeiEq3j3SK5Ql-vQ" name="Compound type 0" description="Compound type (-1: acid, +1: base, 0: neutral)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="PAiMgkJJykGJpbgeNYVTDA" name="Cl" description="Number of chlorine atoms in molecule" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="-ElbCBqfGkO-OKcN-WAfJQ" name="Compound type 1" description="Compound type (-1: acid, +1: base, 0: neutral)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="8TIgPkYkxEWN_qTnmdDf0g" name="base_For_KaPL_Factor" description="Supporting parameter for calculation of pKa- and pH- dependent values of KaPL" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="20">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="PPMMQPLHPk2DKz-JZ2SExQ" name="base_For_logD_Factor" description="Supporting parameter for calculation of pKa- and pH- dependent logD" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0.001">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="XmNlTOV4Wk-Wc7XaJ0RJ0g" name="base_For_P_cell_Factor" description="Supporting parameter for calculation of pKa- and pH- dependent permeability to/from cells" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0.001">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="qNo57TbzOEmQ9gbLAyeu1g" name="base_For_Pint_Factor" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0.1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="8sdWoQO63kWRfVULzowGuw" name="Br" description="Number of bromine atoms in molecule" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="vkxAULwyR0-p3-D5cJgN-Q" name="Lipophilicity" description="Model dependent lipophilicity measure: LogMA / LogP / ..." icon="Parameter" persistable="0" isFixedValue="0" dim="Log Units" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="3" displayUnit="Log Units">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="bSD7Hp1J_0WOeAnBg-1h8A" name="Fraction unbound (plasma)" description="Fraction unbound in plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0.1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="cbBH0E_h9E6vKhFKGFi1aQ" name="Solubility at reference pH" description="Solubility at reference pH" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0.009999" displayUnit="kg/l">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="5Jx_deenCE27jz5P-jn3xA" name="Reference pH" description="Reference pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="7">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="2G4VGIXk6k2MtJhs0jnBHg" name="Solubility gain per charge" description="Supporting parameter for calculation of pKa- and pH- dependent values of intestinal solubilty" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="1000">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="NSqIjJlk90q2lv3VLcpCVg" name="Permeability" description="Permeability" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="ST9ewPUpnE-YK8yV_YQilg" buildMode="Property" isDefault="1" displayUnit="cm/min">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="DEpw5hZUwUGDTKx4H5VTYg" name="Specific intestinal permeability (transcellular)" description="Specific intestinal permeability (transcellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="MHOQGqWip0qzqqfWs4Av6A" buildMode="Property" isDefault="1" displayUnit="cm/min">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="FuuurVVfB0GhRZNxQ8e81w" name="Partition coefficient (water/protein)" description="Partition coefficient water to protein" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="et_Z9z3qrUWQWf_K67ihbA" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="IvlKy-86h0ab0LdJE2Hgiw" name="Treat precipitated drug as" description="Treat precipitated drug as either soluble or insoluble" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="eY8CySXiD0SHWg0NOuwXoQ" name="Aqueous diffusion coefficient" description="Aqueous diffusion coefficient&#xA;of the drug" icon="Parameter" persistable="0" isFixedValue="0" dim="Diffusion coefficient" quantityType="Parameter" negativeValuesAllowed="1" formula="txSvdn3Qi0eFz57EAQowQg" buildMode="Property" isDefault="1" displayUnit="dm²/min">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="7bZ8Kw1SwEOuPS_-nSuTfA" name="Density (drug)" description="Density of drug material" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="1" displayUnit="g/cm³">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="yy9ls1KVzkajywB311HC7Q" name="Immediately dissolve particles smaller than" description="Threshold for the particle radius of immediate dissolution" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="1E-07" displayUnit="dm">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="v3SstK-6M0qQyk8-pQmxaw" name="Radius (solute)" description="Solute radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="D6SIvwugH0GMrd80Qqztiw" buildMode="Property" isDefault="1" displayUnit="dm">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="Du7G_FyCBE6n4PxlxXAQLQ" name="Kd (FcRn)" description="Dissociation constant for binding of drug to FcRn" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="999999" displayUnit="µmol/l">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="7MvTTJGHNUukfOOD2J1wbg" name="Use pH- and pKa-dependent penalty factor for charged molecule fraction" description="Penalty factor for charged molecule fraction is used for &quot;Intestinal permeability (transcellular)&quot; only" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="euLgoDMpyEeJoWYR_GybFQ" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="KS0RvhqdkE6iSD9ZCkuaQA" isDefault="1" displayUnit="µmol/l">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <TransporterMoleculeContainer id="zrqHIUHgHUyjR9qZvaS6Bg" name="PGP" mode="Logical" containerType="Other" transportName="PGP">
+          <Children>
+            <Parameter id="ZDW4LeG3wEeISLFjRY-yLg" name="km" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Global" isDefault="1" value="1" displayUnit="µmol/min">
+              <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+            </Parameter>
+            <TransportBuilder id="tsDT3FpX6EWSLFUfQc8SQA" name="Like" mode="Logical" containerType="Other" createProcessRateParameter="0" processRateParameterPersistable="0" formula="1lvsN49MrUCRR_VWS4Pjlg" transportType="0">
+              <Children>
+                <Parameter id="0RsNYNMwdEq63Oml1xTzPQ" name="Tada" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0" displayUnit="g/cm³">
+                  <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+                </Parameter>
+              </Children>
               <SourceCriteria />
               <TargetCriteria />
-              <Parameters>
-                <Parameter id="c20214b1-3d0e-4c30-846a-fa3067d30169" name="Tada" persistable="0" isFixedValue="0" formula="3695e1ef-8108-4afd-b60f-64a1f9e44a90" dim="Density" quantityType="0" visible="1" canBeVaried="1" />
-              </Parameters>
+              <MoleculeList forAll="1" />
             </TransportBuilder>
-          </ActiveTransportRealizations>
-          <Parameters>
-            <Parameter id="3eaa713e-c31c-4802-999b-efa9302c068a" name="km" persistable="0" isFixedValue="0" formula="9f249c31-8c68-4dde-9b4a-4324bb1dcc42" dim="Rate" quantityType="0" buildMode="Global" visible="1" canBeVaried="1" />
-          </Parameters>
+          </Children>
         </TransporterMoleculeContainer>
+        <Parameter id="hp-5NniA_U-1a-KavaIKCg" name="Calculated specific intestinal permeability (transcellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="MHOQGqWip0qzqqfWs4Av6A" buildMode="Global" isDefault="1" displayUnit="cm/min">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="SlEyldoHrEu9FaTLvbP2wg" name="Total drug mass" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" formula="oosTscPgCUiJqQI_z4d_Ig" buildMode="Property" isDefault="1" displayUnit="µmol">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
       </Children>
       <UsedCalculationMethods>
         <UsedCalculationMethod category="DistributionCellular" calculationMethod="Cellular partition coefficient method - PK-Sim Standard" />
         <UsedCalculationMethod category="DiffusionIntCell" calculationMethod="Cellular permeability - PK-Sim Standard" />
         <UsedCalculationMethod category="DistributionInterstitial" calculationMethod="Interstitial partition coefficient method - Schmitt" />
       </UsedCalculationMethods>
-      <AllPassiveTransports>
-        <TransportBuilder id="5c0c83c4-6c9f-43f9-b741-c5e0ad1c0f7f" name="GFR" dimension="Rate" createProcessRateParameter="0" formula="0c95604c-10fb-40d2-b879-6a886317e4e8" transportType="0">
-          <SourceCriteria />
-          <TargetCriteria />
-          <Parameters>
-            <Parameter id="dbdce0fd-8426-426a-b733-4ff8ec0f9a8a" name="CLSpec" persistable="0" isFixedValue="0" formula="3f93d61b-72e8-4f3b-b2eb-e8efab1d0986" dim="SpecificClearancePerProtein" quantityType="0" visible="1" canBeVaried="1" />
-          </Parameters>
-        </TransportBuilder>
-      </AllPassiveTransports>
     </MoleculeBuilder>
-    <MoleculeBuilder id="00bc72eb-e97c-4c3d-8091-af74bb86c28b" name="PGP" icon="TRANSPORTER" mode="Logical" containerType="Other" isFloating="0" quantityType="Transporter" defaultStartFormula="83dbf546-64c7-4137-b0f0-08f9af5e69ce">
+    <MoleculeBuilder id="Tlpu2Ky_M0WniCVhJk63Pw" name="PGP" icon="TRANSPORTER" mode="Logical" containerType="Other" isFloating="0" quantityType="Transporter" isXenobiotic="1" dim="Amount" defaultStartFormula="afdoe1RXi06lyfYL9riUFQ" displayUnit="µmol">
       <Children>
-        <Parameter id="02a52525-764c-41b0-a632-b2cafa1fbe2f" name="Aqueous diffusion coefficient" description="Aqueous diffusion coefficient&#xA;of the drug" persistable="0" isFixedValue="0" formula="ecf1d1dd-0642-4c4a-821d-46f238cc8c73" dim="DiffusionCoefficient" quantityType="0" buildMode="Property" visible="1" canBeVaried="1" />
-        <Parameter id="d08495e0-d7bc-4ade-a810-e43f55132e48" name="base_For_KaPL_Factor" description="Supporting parameter for calculation of pKa- and pH- dependent values of KaPL" persistable="0" isFixedValue="0" formula="8e3feaf7-f9b1-4530-86a6-a243e329a360" dim="Dimensionless" quantityType="0" buildMode="Property" visible="0" canBeVaried="0" />
-        <Parameter id="c4ad3d2b-0424-4a81-9b19-522b007b6b2f" name="base_For_logD_Factor" description="Supporting parameter for calculation of pKa- and pH- dependent logD" persistable="0" isFixedValue="0" formula="e114303f-5610-4824-b606-714265fec9b1" dim="Dimensionless" quantityType="0" buildMode="Property" visible="0" canBeVaried="0" />
-        <Parameter id="d8913c7b-812e-4fbc-87c0-0b53635d3c77" name="base_For_P_cell_Factor" description="Supporting parameter for calculation of pKa- and pH- dependent permeability to/from cells" persistable="0" isFixedValue="0" formula="415942b5-7e13-4071-92ec-c577cf0b2191" dim="Dimensionless" quantityType="0" buildMode="Property" visible="0" canBeVaried="0" />
-        <Parameter id="0503a47c-38f6-4a33-adfc-52804df30cd3" name="base_For_Pint_Factor" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" persistable="0" isFixedValue="0" formula="0acb637a-38ce-4acf-b81d-d2b714073353" dim="Dimensionless" quantityType="0" buildMode="Property" visible="0" canBeVaried="0" />
-        <Parameter id="526adeda-05f7-4fd8-bf2b-e22ba592355a" name="Br" description="Number of bromine atoms in molecule" persistable="0" isFixedValue="0" formula="154bf5c8-4f5b-4e00-a590-c3eaf7917728" dim="Dimensionless" quantityType="0" buildMode="Property" visible="1" canBeVaried="0" />
-        <Parameter id="4645506e-b9b5-4a03-a64d-4a96267de6cb" name="Cl" description="Number of chlorine atoms in molecule" persistable="0" isFixedValue="0" formula="326cf200-b6e7-4c1e-9eb6-506084d02d35" dim="Dimensionless" quantityType="0" buildMode="Property" visible="1" canBeVaried="0" />
-        <Parameter id="c3f0acb7-2fd5-4da5-981a-8c8a69e36800" name="Compound type 0" description="Compound type (-1: acid, +1: base, 0: neutral)" persistable="0" isFixedValue="0" formula="cacca64d-774e-4d1e-8f86-8b90015b649b" dim="Dimensionless" quantityType="0" buildMode="Property" visible="1" canBeVaried="0" />
-        <Parameter id="2f519a34-86d0-4516-9cf3-b6d261279808" name="Compound type 1" description="Compound type (-1: acid, +1: base, 0: neutral)" persistable="0" isFixedValue="0" formula="aebafb5f-66b2-456d-83ca-3f3dd43f980a" dim="Dimensionless" quantityType="0" buildMode="Property" visible="1" canBeVaried="0" />
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-        <Parameter id="40079d60-f2d5-496c-9c1c-eb37df335dda" name="Reference pH" description="Reference pH" persistable="0" isFixedValue="0" formula="2785b8c0-2e50-4f79-9942-bfb342bb8ccb" dim="Dimensionless" quantityType="0" buildMode="Property" visible="1" canBeVaried="1" />
-        <Parameter id="9a2f506c-534a-4d95-aba6-9f99d170f392" name="Solubility at reference pH" description="Solubility at reference pH" persistable="0" isFixedValue="0" formula="5a6c5770-8b03-493e-838e-f2b2886ede81" dim="Concentration" quantityType="0" buildMode="Property" visible="1" canBeVaried="1" />
-        <Parameter id="0fc42bc7-7525-4802-855d-3711894d4752" name="Solubility gain per charge" description="Supporting parameter for calculation of pKa- and pH- dependent values of intestinal solubilty" persistable="0" isFixedValue="0" formula="b6a217e0-8372-417c-bb5f-074803a0da73" dim="Dimensionless" quantityType="0" buildMode="Property" visible="1" canBeVaried="0" />
-        <Parameter id="778b5630-fd97-4795-8968-392617223b8d" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" persistable="0" isFixedValue="0" formula="1d7f0e1b-a6aa-43ab-91b8-ffa0f43fa938" dim="Dimensionless" quantityType="0" buildMode="Property" visible="0" canBeVaried="0" />
-        <Parameter id="b0943610-bd54-431d-b9e1-8e4706bbbc40" name="Specific intestinal permeability (transcellular)" description="Specific intestinal permeability (transcellular)" persistable="0" isFixedValue="0" formula="2e21b031-4150-413c-8bfe-428d023baf36" dim="Velocity" quantityType="0" buildMode="Property" visible="1" canBeVaried="1" />
-        <Parameter id="4695315e-77d2-4d08-b846-0dd0f927f294" name="Total oral drug mass" description="Total oral drug mass" persistable="0" isFixedValue="0" formula="bba2067d-2c4c-4db4-851d-d41cbb10baaf" dim="Amount" quantityType="0" buildMode="Property" visible="0" canBeVaried="0" />
-        <Parameter id="27d28eb4-8fcc-4c18-92c6-475d25f2a148" name="Treat precipitated drug as" description="Treat precipitated drug as either soluble or insoluble" persistable="0" isFixedValue="0" formula="f563d5be-24e3-4a71-a709-1fd8548fed1d" dim="Dimensionless" quantityType="0" buildMode="Property" visible="1" canBeVaried="1" />
-        <Parameter id="e0a736a8-2a70-4f17-b7bc-595bb5bf91d9" name="Use pH- and pKa-dependent penalty factor for charged molecule fraction" description="Penalty factor for charged molecule fraction is used for &quot;Intestinal permeability (transcellular)&quot; only" persistable="0" isFixedValue="0" formula="7d8211a1-d9af-4dbd-a46f-1fd657edf128" dim="Dimensionless" quantityType="0" buildMode="Property" visible="1" canBeVaried="1" />
+        <Parameter id="BQpaTpL08k-79k2fgBWIPg" name="Aqueous diffusion coefficient" description="Aqueous diffusion coefficient&#xA;of the drug" icon="Parameter" persistable="0" isFixedValue="0" dim="Diffusion coefficient" quantityType="Parameter" negativeValuesAllowed="1" formula="txSvdn3Qi0eFz57EAQowQg" buildMode="Property" isDefault="1" displayUnit="dm²/min">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="z4pnsiwIhE6U5vAB7DlaqQ" name="base_For_KaPL_Factor" description="Supporting parameter for calculation of pKa- and pH- dependent values of KaPL" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="20">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="KtlepVH4e0e57RI6pqil9g" name="base_For_logD_Factor" description="Supporting parameter for calculation of pKa- and pH- dependent logD" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0.001">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="SMhpbxgqvk2oTsN6Dh8cxw" name="base_For_P_cell_Factor" description="Supporting parameter for calculation of pKa- and pH- dependent permeability to/from cells" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0.001">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="o3oPUNoAGkO4IAqY_8KGKA" name="base_For_Pint_Factor" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0.1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="kRf4ZuLFLE6NMqE6-mN7ew" name="Br" description="Number of bromine atoms in molecule" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="95kPZU8vUkGVSvCGTl2s2A" name="Cl" description="Number of chlorine atoms in molecule" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="dbz2DZhBKUuTyTGjtIS8Ag" name="Compound type 0" description="Compound type (-1: acid, +1: base, 0: neutral)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="2byQqRXZ50-UA2PEANJKIQ" name="Compound type 1" description="Compound type (-1: acid, +1: base, 0: neutral)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="7B9IpUe1bEet0OfUXdD5FQ" name="Compound type 2" description="Compound type (-1: acid, +1: base, 0: neutral)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="ldIGomSjj0K1tbtPevFUkQ" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="KS0RvhqdkE6iSD9ZCkuaQA" isDefault="1" displayUnit="µmol/l">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="2IhG5J-nz0a631y5BenKyw" name="CT_ACID" description="Constant for compound type acid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="-1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="0VUqMVFdH0KX91r8TLsUxQ" name="CT_BASE" description="Constant for compound type base" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="fXiK6bqag0i1T_jVN_k0vA" name="CT_NEUTRAL" description="Constant for compound type neutral" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="_APGncCuuk-pz4B3dkiJKQ" name="Density (drug)" description="Density of drug material" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="1" displayUnit="g/cm³">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="Wdk_cYqYcUSSgKcL-1F_Sg" name="Effective molecular weight" description="Effective molecular weight" icon="Parameter" persistable="0" isFixedValue="0" dim="Molecular weight" quantityType="Parameter" negativeValuesAllowed="1" formula="R4B76J5_xES-bwD0V4-Eaw" buildMode="Property" isDefault="1" displayUnit="g/mol">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="aix8yID9iEqwbykVSdvg9A" name="F" description="Number of fluorine atoms in molecule" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="wE70an7XPUqYgzgRltmjAA" name="Fraction unbound (plasma)" description="Fraction unbound in plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0.1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="Pei0M21f9EapqjvZ-no0Vw" name="Has halogens" description="Supporting parameter for compound" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="UgC4FkZ8bUy4VRgrXxBRdg" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="ed2uZX5ptUuZNSO0iz-2Wg" name="I" description="Number of iodine atoms in molecule" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="6BDclEjrsk6G9h61FhJ2tw" name="Immediately dissolve particles smaller than" description="Threshold for the particle radius of immediate dissolution" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="1E-07" displayUnit="dm">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="ZlSk81ZTYkOdmKqG1EIG_w" name="Is diprotic acid" description="Is diprotic acid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="-lEpazMaXECL2cECmijO5w" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="e1py7V8e80CuAmCjvEjzzw" name="Is diprotic base" description="Is diprotic base" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="z88_2ktlt0WYVR3zNrEI4w" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="2zm886C91UK0HAPAAHb1YQ" name="Is diprotic base monoprotic acid" description="Is diprotic base monoprotic acid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="2kAuN4ISc0mmzBpjfE5exQ" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="ps_uZPo_Q0aaW-7DVsNt0A" name="Is floating in lumen" description="Is floating in lumen" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="3OlGc5AHlkuPolAB777-BA" name="Is monoprotic acid" description="Is monoprotic acid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="NPqclKDUXEu43HxlSghvTw" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="ydIQhx33tkeH5inv6RFizA" name="Is monoprotic base" description="Is monoprotic base" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="pEu5n_jVkUmnFyat9x1pOA" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="M7WcSaFp_kazxjn9p2Lo-g" name="Is monoprotic base diprotic acid" description="Is monoprotic base diprotic acid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="McjQLaQlbUStSYVN89VisA" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="m7-By12iv0WwKBI-8Hi55Q" name="Is monoprotic base monoprotic acid" description="Is monoprotic base monoprotic acid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="D3sGK2m-wkmY4S9HAXQqDQ" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="Vm8IkcsF-Uim_MNTDJV1Rw" name="Is neutral" description="Supporting parameter for partition coeffs in RR-Modell" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="t9A3_RncCEe-6VsJzVVDRw" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="TBWWu5it9Uy-s8eWJfmXOQ" name="Is small molecule" description="Treat compound as small molecule or not (if not, both organ specific and intestinal permeability will be set to zero)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="s77Jj3_BCESZaiHrxlQq_g" name="Is strong base" description="Supporting parameter for partition coeffs in RR-Modell (at least one basic pKa&gt;=7)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="gxXfWQ5WI0-5Mp5-aksjqg" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="2h4ifoLc8kCsKuH8SoXDlA" name="Is triprotic acid" description="Is triprotic acid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_EL9ispm0kO1wy6gAxVXkg" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="9GddVCCnEU2Ar6oEHPnNVw" name="Is triprotic base" description="Is triprotic base" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="sqs0VyfLeUC2NcI0TsI-jg" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="BnpAH6vTdkyRy-CkU-ErEg" name="Kd (FcRn)" description="Dissociation constant for binding of drug to FcRn" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="999999" displayUnit="µmol/l">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="bcMYkF1StUSWiXgESDyETw" name="Lipophilicity" description="Model dependent lipophilicity measure: LogMA / LogP / ..." icon="Parameter" persistable="0" isFixedValue="0" dim="Log Units" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="3" displayUnit="Log Units">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="tl8v5va9mES2H2KOvMDufw" name="Molecular weight" description="Molecular weight" icon="Parameter" persistable="0" isFixedValue="0" dim="Molecular weight" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="4E-07" displayUnit="g/mol">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="eflAW1tBakKk89N1BjCB9Q" name="Partition coefficient (water/protein)" description="Partition coefficient water to protein" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="et_Z9z3qrUWQWf_K67ihbA" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="UScPZ34QJUKvZV-7X_qA4Q" name="Permeability" description="Permeability" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="ST9ewPUpnE-YK8yV_YQilg" buildMode="Property" isDefault="1" displayUnit="cm/min">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="oHJpfoxqQUevZexdDjEwuA" name="pKa value 0" description="pKa value" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="R3L8zwaf10OZ01fuv4_5ZQ" name="pKa value 1" description="pKa value" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="5yf78pUmgUmbfBoFqyFAtQ" name="pKa value 2" description="pKa value" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="WYMKboSUQka27-oomvBVNw" name="pKa_Acid_0" description="Smallest acid pKa" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="oPf_Gv2bXUWOWAE-AmELkw" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="kcAoAsU-h0e85AYGNKNliw" name="pKa_Acid_1" description="Middle acid pKa" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="WW5qavloYE-lujFoLxCkaA" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="TFnIzaeivU2b22YOX9Xuow" name="pKa_Acid_2" description="Largest acid pKa" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="SVyCFbx1XkyyzC6_Zssh-w" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="13_l3lwUyEKCz8fo9ZZY7g" name="pKa_Acids_Count" description="Number of acidic groups in compound" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="hVFHSgq4mE2pr2wDGly2Kg" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="aWlwCjBArUSX_zDsQ62rBw" name="pKa_Base_0" description="Smallest base pKa" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BU5bAzzxxE2iG6SFmmTDBQ" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="wVz7dBEOTEaiopKVPfFk0Q" name="pKa_Base_1" description="Middle base pKa" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="M8KJNlRsPUO_m1iltcp6MA" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="hBT6znkzgEqXnGyQr2WC4Q" name="pKa_Base_2" description="Largest base pKa" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="5VjEtnaMVkaxMtRdxgTnvw" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="FJAlgwowEUCnsXrd48qo4g" name="pKa_Bases_Count" description="Number of basic groups in compound" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="qnQGGHj5N0yYwVLR28J0Jg" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="iUAyh39wVECmMlm47J-NzA" name="pKa_OneAcid_0" description="Smallest acid pKa for compound with 1 acid group" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="HRwuurQc1EaA7ncM4pJB1w" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="uvqwCnzOOkKou53OeRwHxw" name="pKa_OneBase_0" description="Smallest base pKa for compound with 1 base group" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="VgrdscGuxkWoruk0VqGODQ" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="LgUjIlgAdEya-AjNw6FKsg" name="pKa_pH_WS_sol_F1" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="0Wd2c452xki5zWpUUc_OWw" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="LQM0J19gsUu9KT6JgM1jQQ" name="pKa_pH_WS_sol_F2" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="nqxOK6X-ykiHoJUQoY5xHw" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="S7jB3vbpx0mbAMgGa0PC1g" name="pKa_pH_WS_sol_F3" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ISS_B9d4N0aKX_Zb6w1qmA" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="f5CyasqTZ0KofwjA1uabfg" name="pKa_pH_WS_sol_K1" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="dY2_MKkdT0mL-wNbBJB2bw" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="mdTl40VLZkihvVbWlBP2rQ" name="pKa_pH_WS_sol_K2" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Szzn0TV2zUq4rihK7WPHOA" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="mAGfTg7WzECVSU7EWMl8TA" name="pKa_pH_WS_sol_K3" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CrwUJZDPdkuxvUw3_MfYvg" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="Ay6097BKRkKG4x37S-jPEg" name="pKa_pH_WS_sol_K4" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ebR5s5oYGk2nhp7Iotfttw" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="s7DACYIPi0Cz6AAYNffK4g" name="pKa_pH_WS_sol_K5" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="K6Oz-wT3WEuZcxbCaxXV7g" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="3jIxs8Lhfk6J3O8M6rAq8g" name="pKa_pH_WS_sol_K6" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="q19OAc-2IEitwwqwqisjJA" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="Di01ot0MsESGjn8L1yRVZA" name="pKa_pH_WS_sol_K7" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="J-GLHfhTdkaWVR-lyMnR3g" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="t16Ntysj3EyUSYDX_Gv8pQ" name="pKa_pH_WS_sol_K8" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="78-kbB0qc0CtHWLIQiWMnA" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="f4yQmHxH1Eeg_JB2vJ0_CA" name="pKa_ThreeAcids_0" description="Smallest acid pKa for compound with 3 acid groups" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="vHT9x5jzPEm5GXz_0oOFYQ" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="Jly0H-pj7kaMs5qwY2D_RA" name="pKa_ThreeAcids_1" description="Middle acid pKa for compound with 3 acid groups" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="v4oEcuuGzEC4KPs1famoqw" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="xd3SD8FrgUujNUh_p60slA" name="pKa_ThreeBases_0" description="Smallest base pKa for compound with 3 base groups" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="RPrfJEOyd0u4CcBIIb2hEA" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="QNFm3rY3tUK3GBL1q1l2gQ" name="pKa_ThreeBases_1" description="Middle base pKa for compound with 3 base groups" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Q-1Sy1dGj0qhtdiBpiCSvw" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="1j1IN44_fUeLCVaVvYtJHQ" name="pKa_TwoAcids_0" description="Smallest acid pKa for compound with 2 acid groups" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="2xsDcah1h0iQ7F5tc_jRlA" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="JO7ldo8rfEqSeZu0ujMJ9Q" name="pKa_TwoAcids_1" description="Middle acid pKa for compound with 2 acid groups" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="k4dwYQRYEEGdYiS5bqzvQA" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="VSy614dtb0mKrbxkHi8vxQ" name="pKa_TwoBases_0" description="Smallest base pKa for compound with 2 base groups" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="f7AVAt7mVUezoHQiNVw1iw" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="pQwrX4OkgUy2lrQO1jxRVw" name="pKa_TwoBases_1" description="Middle base pKa for compound with 2 base groups" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="8uBCH8bTCkWgOgtPqEqf7A" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="XNshlk3BgUqbZU7UrqEsJw" name="Radius (solute)" description="Solute radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="D6SIvwugH0GMrd80Qqztiw" buildMode="Property" isDefault="1" displayUnit="dm">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="sZQXAW3nTUOH1zSBJWvhRA" name="Reference pH" description="Reference pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="7">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="1QsQkoiP20uxQmKSgVLWxA" name="Solubility at reference pH" description="Solubility at reference pH" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0.009999" displayUnit="kg/l">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="rwJijcY5fE2FWZVSAZVwjQ" name="Solubility gain per charge" description="Supporting parameter for calculation of pKa- and pH- dependent values of intestinal solubilty" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="1000">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="WkM0G56YkEiVNh5Rfeow7Q" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="hl_xHXhJFE2Adq6jBGTSpA" buildMode="Property" isDefault="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="KBe3SXkje0GIxXwMpXaZsA" name="Specific intestinal permeability (transcellular)" description="Specific intestinal permeability (transcellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="MHOQGqWip0qzqqfWs4Av6A" buildMode="Property" isDefault="1" displayUnit="cm/min">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="ZdHbyDZgKEGdOc-fCAoXrA" name="Total oral drug mass" description="Total oral drug mass" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0" displayUnit="µmol">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="h3HiotzX4kmdistmWodWAA" name="Treat precipitated drug as" description="Treat precipitated drug as either soluble or insoluble" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="1">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="8F_YE6JfsUGsHY6r0D3ntw" name="Use pH- and pKa-dependent penalty factor for charged molecule fraction" description="Penalty factor for charged molecule fraction is used for &quot;Intestinal permeability (transcellular)&quot; only" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="VF_aeiKgAEWl6vdcd0Kc3g" name="Calculated specific intestinal permeability (transcellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="MHOQGqWip0qzqqfWs4Av6A" buildMode="Global" isDefault="1" displayUnit="cm/min">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
+        <Parameter id="9OPzn0P2bkSdV3V_8qVZFg" name="Total drug mass" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" formula="oosTscPgCUiJqQI_z4d_Ig" buildMode="Property" isDefault="1" displayUnit="µmol">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
       </Children>
       <UsedCalculationMethods>
         <UsedCalculationMethod category="DistributionCellular" calculationMethod="No Calculation Method" />
@@ -205,7 +532,7 @@
   </Builders>
   <FormulaCache>
     <Formulas>
-      <Formula id="e5fba224-dd0b-48b9-b2b6-58320cdc413e" name="PARAM_pKa_Acids_Count" dim="Dimensionless" formula="(CT0 = CT_ACID ? 1 : 0) + (CT1 = CT_ACID ? 1 : 0) + (CT2 = CT_ACID ? 1 : 0)">
+      <Formula id="hVFHSgq4mE2pr2wDGly2Kg" name="PARAM_pKa_Acids_Count" formula="(CT0 = CT_ACID ? 1 : 0) + (CT1 = CT_ACID ? 1 : 0) + (CT2 = CT_ACID ? 1 : 0)">
         <Paths>
           <Path path="0" as="1" />
           <Path path="2" as="3" />
@@ -213,27 +540,27 @@
           <Path path="6" as="7" />
         </Paths>
       </Formula>
-      <Formula id="05f11b57-25ab-40a4-8d35-6c184f907478" name="PARAM_pKa_pH_WS_sol_K2" dim="Dimensionless" formula="(1-F1)*F2*F3">
+      <Formula id="Szzn0TV2zUq4rihK7WPHOA" name="PARAM_pKa_pH_WS_sol_K2" formula="(1-F1)*F2*F3">
         <Paths>
           <Path path="8" as="9" />
           <Path path="10" as="11" />
           <Path path="12" as="13" />
         </Paths>
       </Formula>
-      <Formula id="4426ebce-4576-4306-ba26-9276ce85e1fc" name="PARAM_pKa_Acid_0" dim="Dimensionless" formula="pKa_OneAcid_0+pKa_TwoAcids_0+pKa_ThreeAcids_0">
+      <Formula id="oPf_Gv2bXUWOWAE-AmELkw" name="PARAM_pKa_Acid_0" formula="pKa_OneAcid_0+pKa_TwoAcids_0+pKa_ThreeAcids_0">
         <Paths>
           <Path path="14" as="15" />
           <Path path="16" as="17" />
           <Path path="18" as="19" />
         </Paths>
       </Formula>
-      <Formula id="23604d2d-cb66-4134-92a0-efd2f8824bf3" name="PARAM_IsTriproticAcid" dim="Dimensionless" formula="pKa_Acids_Count=3 &amp; pKa_Bases_Count = 0 ? 1 : 0">
+      <Formula id="_EL9ispm0kO1wy6gAxVXkg" name="PARAM_IsTriproticAcid" formula="pKa_Acids_Count=3 &amp; pKa_Bases_Count = 0 ? 1 : 0">
         <Paths>
           <Path path="20" as="21" />
           <Path path="22" as="23" />
         </Paths>
       </Formula>
-      <Formula id="ccba3f94-63e1-4602-abb7-72324672e8ca" name="PARAM_pKa_Acid_2" dim="Dimensionless" formula="IsTriproticAcid ? Max (pKa_0; Max (pKa_1; pKa_2)) : 0">
+      <Formula id="SVyCFbx1XkyyzC6_Zssh-w" name="PARAM_pKa_Acid_2" formula="IsTriproticAcid ? Max (pKa_0; Max (pKa_1; pKa_2)) : 0">
         <Paths>
           <Path path="24" as="25" />
           <Path path="26" as="27" />
@@ -241,7 +568,7 @@
           <Path path="30" as="31" />
         </Paths>
       </Formula>
-      <Formula id="40627d66-82e6-45aa-b770-43173bac6f11" name="PARAM_HasStrongBase" dim="Dimensionless" formula="(CT_0=1 AND pKa_0&gt;=7) OR (CT_1=1 AND pKa_1&gt;=7) OR (CT_2=1 AND pKa_2&gt;=7)">
+      <Formula id="gxXfWQ5WI0-5Mp5-aksjqg" name="PARAM_HasStrongBase" formula="(CT_0=1 AND pKa_0&gt;=7) OR (CT_1=1 AND pKa_1&gt;=7) OR (CT_2=1 AND pKa_2&gt;=7)">
         <Paths>
           <Path path="0" as="32" />
           <Path path="2" as="33" />
@@ -251,20 +578,20 @@
           <Path path="30" as="31" />
         </Paths>
       </Formula>
-      <Formula id="f08e67b2-3f0f-499e-b30d-e4d0ae2dba59" name="PARAM_pKa_Base_0" dim="Dimensionless" formula="pKa_OneBase_0+pKa_TwoBases_0+pKa_ThreeBases_0">
+      <Formula id="BU5bAzzxxE2iG6SFmmTDBQ" name="PARAM_pKa_Base_0" formula="pKa_OneBase_0+pKa_TwoBases_0+pKa_ThreeBases_0">
         <Paths>
           <Path path="35" as="36" />
           <Path path="37" as="38" />
           <Path path="39" as="40" />
         </Paths>
       </Formula>
-      <Formula id="4f957f35-6e5f-4207-9f13-3af45171ac94" name="PARAM_pKa_Base_1" dim="Dimensionless" formula="pKa_TwoBases_1+pKa_ThreeBases_1">
+      <Formula id="M8KJNlRsPUO_m1iltcp6MA" name="PARAM_pKa_Base_1" formula="pKa_TwoBases_1+pKa_ThreeBases_1">
         <Paths>
           <Path path="41" as="42" />
           <Path path="43" as="44" />
         </Paths>
       </Formula>
-      <Formula id="588827f7-e29d-4247-961c-686244ab7ec6" name="PARAM_pKa_Base_2" dim="Dimensionless" formula="IsTriproticBase ? Max (pKa_0; Max (pKa_1; pKa_2)) : 0">
+      <Formula id="5VjEtnaMVkaxMtRdxgTnvw" name="PARAM_pKa_Base_2" formula="IsTriproticBase ? Max (pKa_0; Max (pKa_1; pKa_2)) : 0">
         <Paths>
           <Path path="45" as="46" />
           <Path path="26" as="27" />
@@ -272,7 +599,7 @@
           <Path path="30" as="31" />
         </Paths>
       </Formula>
-      <Formula id="4bfaaf73-ce9c-405c-81d1-d5eaeb3ac7e2" name="PARAM_pKa_Bases_Count" dim="Dimensionless" formula="(CT0 = CT_BASE ? 1 : 0) + (CT1 = CT_BASE ? 1 : 0) + (CT2 = CT_BASE ? 1 : 0)">
+      <Formula id="qnQGGHj5N0yYwVLR28J0Jg" name="PARAM_pKa_Bases_Count" formula="(CT0 = CT_BASE ? 1 : 0) + (CT1 = CT_BASE ? 1 : 0) + (CT2 = CT_BASE ? 1 : 0)">
         <Paths>
           <Path path="0" as="1" />
           <Path path="2" as="3" />
@@ -280,7 +607,7 @@
           <Path path="47" as="48" />
         </Paths>
       </Formula>
-      <Formula id="1ba98e86-dddb-4885-9445-62c22b2cac45" name="PARAM_pKa_OneAcid_0" dim="Dimensionless" formula="pKa_Acids_Count=1 ? (CT0=CT_ACID ? pKa_0 : (CT1=CT_ACID ? pKa_1 : pKa_2)) : 0">
+      <Formula id="HRwuurQc1EaA7ncM4pJB1w" name="PARAM_pKa_OneAcid_0" formula="pKa_Acids_Count=1 ? (CT0=CT_ACID ? pKa_0 : (CT1=CT_ACID ? pKa_1 : pKa_2)) : 0">
         <Paths>
           <Path path="0" as="1" />
           <Path path="2" as="3" />
@@ -291,7 +618,7 @@
           <Path path="20" as="21" />
         </Paths>
       </Formula>
-      <Formula id="603773bf-5e5c-4257-9a53-f1ad8cf91850" name="PARAM_pKa_OneBase_0" dim="Dimensionless" formula="pKa_Bases_Count=1 ? (CT0=CT_BASE ? pKa_0 : (CT1=CT_BASE ? pKa_1 : pKa_2)) : 0">
+      <Formula id="VgrdscGuxkWoruk0VqGODQ" name="PARAM_pKa_OneBase_0" formula="pKa_Bases_Count=1 ? (CT0=CT_BASE ? pKa_0 : (CT1=CT_BASE ? pKa_1 : pKa_2)) : 0">
         <Paths>
           <Path path="0" as="1" />
           <Path path="2" as="3" />
@@ -302,7 +629,7 @@
           <Path path="22" as="23" />
         </Paths>
       </Formula>
-      <Formula id="c7869dc9-aeea-4dc8-951e-38db528f4222" name="PARAM_pKa_pH_WS_sol_F1" dim="Dimensionless" formula="CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1">
+      <Formula id="0Wd2c452xki5zWpUUc_OWw" name="PARAM_pKa_pH_WS_sol_F1" formula="CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1">
         <Paths>
           <Path path="0" as="1" />
           <Path path="49" as="50" />
@@ -310,7 +637,7 @@
           <Path path="51" as="52" />
         </Paths>
       </Formula>
-      <Formula id="592d062d-25e4-4383-bffc-0d8e70095d89" name="PARAM_pKa_pH_WS_sol_F2" dim="Dimensionless" formula="CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1">
+      <Formula id="nqxOK6X-ykiHoJUQoY5xHw" name="PARAM_pKa_pH_WS_sol_F2" formula="CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1">
         <Paths>
           <Path path="2" as="3" />
           <Path path="49" as="50" />
@@ -318,7 +645,7 @@
           <Path path="51" as="52" />
         </Paths>
       </Formula>
-      <Formula id="5a89c8e5-9d1c-48bb-afd9-0a39b820c330" name="PARAM_pKa_pH_WS_sol_F3" dim="Dimensionless" formula="CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1">
+      <Formula id="ISS_B9d4N0aKX_Zb6w1qmA" name="PARAM_pKa_pH_WS_sol_F3" formula="CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1">
         <Paths>
           <Path path="4" as="5" />
           <Path path="49" as="50" />
@@ -326,13 +653,13 @@
           <Path path="51" as="52" />
         </Paths>
       </Formula>
-      <Formula id="13adb5a3-ebe2-47ee-ad79-d6d3b4caecd7" name="PARAM_pKa_Acid_1" dim="Dimensionless" formula="pKa_TwoAcids_1+pKa_ThreeAcids_1">
+      <Formula id="WW5qavloYE-lujFoLxCkaA" name="PARAM_pKa_Acid_1" formula="pKa_TwoAcids_1+pKa_ThreeAcids_1">
         <Paths>
           <Path path="53" as="54" />
           <Path path="55" as="56" />
         </Paths>
       </Formula>
-      <Formula id="3dfa88c0-e274-4976-8510-e80070e6cbc9" name="PARAM_MWEff" dim="MolecularWeight" formula="MW - F * 17 - Cl * 22 - Br * 62 - I * 98">
+      <Formula id="R4B76J5_xES-bwD0V4-Eaw" name="PARAM_MWEff" dim="Molecular weight" formula="MW - F * 0.000000017 - Cl * 0.000000022 - Br * 0.000000062 - I * 0.000000098">
         <Paths>
           <Path path="57" as="58" />
           <Path path="59" as="60" />
@@ -341,69 +668,69 @@
           <Path path="65" as="66" dim="67" />
         </Paths>
       </Formula>
-      <Formula id="f9717cac-a14a-47a3-94e2-8a54145ed3f3" name="PARAM_IsTriproticBase" dim="Dimensionless" formula="pKa_Acids_Count=0 &amp; pKa_Bases_Count = 3 ? 1 : 0">
+      <Formula id="sqs0VyfLeUC2NcI0TsI-jg" name="PARAM_IsTriproticBase" formula="pKa_Acids_Count=0 &amp; pKa_Bases_Count = 3 ? 1 : 0">
         <Paths>
           <Path path="20" as="21" />
           <Path path="22" as="23" />
         </Paths>
       </Formula>
-      <Formula id="00905a5c-afb6-49b3-af8a-d699d3f35392" name="PARAM_pKa_pH_WS_sol_K3" dim="Dimensionless" formula="F1*(1-F2)*F3">
+      <Formula id="CrwUJZDPdkuxvUw3_MfYvg" name="PARAM_pKa_pH_WS_sol_K3" formula="F1*(1-F2)*F3">
         <Paths>
           <Path path="8" as="9" />
           <Path path="10" as="11" />
           <Path path="12" as="13" />
         </Paths>
       </Formula>
-      <Formula id="fe011bb9-63bf-4abe-982c-67e714eb9ef2" name="PARAM_IsDiproticAcid" dim="Dimensionless" formula="pKa_Acids_Count=2 &amp; pKa_Bases_Count = 0 ? 1 : 0">
+      <Formula id="-lEpazMaXECL2cECmijO5w" name="PARAM_IsDiproticAcid" formula="pKa_Acids_Count=2 &amp; pKa_Bases_Count = 0 ? 1 : 0">
         <Paths>
           <Path path="20" as="21" />
           <Path path="22" as="23" />
         </Paths>
       </Formula>
-      <Formula id="c2f2c8b1-45e2-4467-9ada-a60d8f8b83dc" name="PARAM_IsDiproticBase" dim="Dimensionless" formula="pKa_Acids_Count=0 &amp; pKa_Bases_Count = 2 ? 1 : 0">
+      <Formula id="z88_2ktlt0WYVR3zNrEI4w" name="PARAM_IsDiproticBase" formula="pKa_Acids_Count=0 &amp; pKa_Bases_Count = 2 ? 1 : 0">
         <Paths>
           <Path path="20" as="21" />
           <Path path="22" as="23" />
         </Paths>
       </Formula>
-      <Formula id="780e828f-b5ee-49fb-9602-df08118794c7" name="PARAM_IsDiproticBaseMonoproticAcid" dim="Dimensionless" formula="pKa_Acids_Count=1 &amp; pKa_Bases_Count = 2 ? 1 : 0">
+      <Formula id="2kAuN4ISc0mmzBpjfE5exQ" name="PARAM_IsDiproticBaseMonoproticAcid" formula="pKa_Acids_Count=1 &amp; pKa_Bases_Count = 2 ? 1 : 0">
         <Paths>
           <Path path="20" as="21" />
           <Path path="22" as="23" />
         </Paths>
       </Formula>
-      <Formula id="1ffe8919-ce6b-4d1b-ad0f-025c20b9c1a1" name="PARAM_IsMonoproticAcid" dim="Dimensionless" formula="pKa_Acids_Count=1 &amp; pKa_Bases_Count = 0 ? 1 : 0">
+      <Formula id="NPqclKDUXEu43HxlSghvTw" name="PARAM_IsMonoproticAcid" formula="pKa_Acids_Count=1 &amp; pKa_Bases_Count = 0 ? 1 : 0">
         <Paths>
           <Path path="20" as="21" />
           <Path path="22" as="23" />
         </Paths>
       </Formula>
-      <Formula id="261c8b1d-4a70-4e5d-8c50-26da11a8ae53" name="PARAM_IsMonoproticBase" dim="Dimensionless" formula="pKa_Acids_Count=0 &amp; pKa_Bases_Count = 1 ? 1 : 0">
+      <Formula id="pEu5n_jVkUmnFyat9x1pOA" name="PARAM_IsMonoproticBase" formula="pKa_Acids_Count=0 &amp; pKa_Bases_Count = 1 ? 1 : 0">
         <Paths>
           <Path path="20" as="21" />
           <Path path="22" as="23" />
         </Paths>
       </Formula>
-      <Formula id="f807db4d-d64b-471b-9bf1-d0b47f08aa73" name="PARAM_IsMonoproticBaseDiproticAcid" dim="Dimensionless" formula="pKa_Acids_Count=2 &amp; pKa_Bases_Count = 1 ? 1 : 0">
+      <Formula id="McjQLaQlbUStSYVN89VisA" name="PARAM_IsMonoproticBaseDiproticAcid" formula="pKa_Acids_Count=2 &amp; pKa_Bases_Count = 1 ? 1 : 0">
         <Paths>
           <Path path="20" as="21" />
           <Path path="22" as="23" />
         </Paths>
       </Formula>
-      <Formula id="d747cc1c-f2fc-4731-adb1-99f28358d033" name="PARAM_IsMonoproticBaseMonoproticAcid" dim="Dimensionless" formula="pKa_Acids_Count=1 &amp; pKa_Bases_Count = 1 ? 1 : 0">
+      <Formula id="D3sGK2m-wkmY4S9HAXQqDQ" name="PARAM_IsMonoproticBaseMonoproticAcid" formula="pKa_Acids_Count=1 &amp; pKa_Bases_Count = 1 ? 1 : 0">
         <Paths>
           <Path path="20" as="21" />
           <Path path="22" as="23" />
         </Paths>
       </Formula>
-      <Formula id="b72804f9-2ec0-46d1-bfb9-b25c304bf709" name="PARAM_IsNeutral" dim="Dimensionless" formula="CT_0 = 0 AND CT_1 = 0 AND CT_2 = 0">
+      <Formula id="t9A3_RncCEe-6VsJzVVDRw" name="PARAM_IsNeutral" formula="CT_0 = 0 AND CT_1 = 0 AND CT_2 = 0">
         <Paths>
           <Path path="0" as="32" />
           <Path path="2" as="33" />
           <Path path="4" as="34" />
         </Paths>
       </Formula>
-      <Formula id="d89cc30f-f8cd-4044-93f2-25b9cf93f6e9" name="PARAM_HasHalogens" dim="Dimensionless" formula="Br + Chlor + F + I &gt; 0">
+      <Formula id="UgC4FkZ8bUy4VRgrXxBRdg" name="PARAM_HasHalogens" formula="Br + Chlor + F + I &gt; 0">
         <Paths>
           <Path path="57" as="58" />
           <Path path="59" as="68" />
@@ -411,14 +738,14 @@
           <Path path="63" as="64" />
         </Paths>
       </Formula>
-      <Formula id="ae8fe106-e589-490e-9b19-025db8e6f438" name="PARAM_pKa_pH_WS_sol_K1" dim="Dimensionless" formula="F1*F2*F3">
+      <Formula id="dY2_MKkdT0mL-wNbBJB2bw" name="PARAM_pKa_pH_WS_sol_K1" formula="F1*F2*F3">
         <Paths>
           <Path path="8" as="9" />
           <Path path="10" as="11" />
           <Path path="12" as="13" />
         </Paths>
       </Formula>
-      <Formula id="cd365569-a477-4848-b37a-f2c2a1ba1bcb" name="PARAM_pKa_TwoBases_0" dim="Dimensionless" formula="pKa_Bases_Count=2 ? (CT0 != CT_BASE ? Min(pKa_1;pKa_2) : (CT1 != CT_BASE ? Min(pKa_0;pKa_2) : Min(pKa_0;pKa_1))) : 0">
+      <Formula id="f7AVAt7mVUezoHQiNVw1iw" name="PARAM_pKa_TwoBases_0" formula="pKa_Bases_Count=2 ? (CT0 != CT_BASE ? Min(pKa_1;pKa_2) : (CT1 != CT_BASE ? Min(pKa_0;pKa_2) : Min(pKa_0;pKa_1))) : 0">
         <Paths>
           <Path path="0" as="1" />
           <Path path="2" as="3" />
@@ -429,42 +756,42 @@
           <Path path="22" as="23" />
         </Paths>
       </Formula>
-      <Formula id="391179c8-77e7-4376-ab6e-a24155a46d5c" name="PARAM_pKa_pH_WS_sol_K4" dim="Dimensionless" formula="F1*F2*(1-F3)">
+      <Formula id="ebR5s5oYGk2nhp7Iotfttw" name="PARAM_pKa_pH_WS_sol_K4" formula="F1*F2*(1-F3)">
         <Paths>
           <Path path="8" as="9" />
           <Path path="10" as="11" />
           <Path path="12" as="13" />
         </Paths>
       </Formula>
-      <Formula id="804656e6-b3ae-4d1a-9bca-1a4527484336" name="PARAM_pKa_pH_WS_sol_K5" dim="Dimensionless" formula="(1-F1)*(1-F2)*F3">
+      <Formula id="K6Oz-wT3WEuZcxbCaxXV7g" name="PARAM_pKa_pH_WS_sol_K5" formula="(1-F1)*(1-F2)*F3">
         <Paths>
           <Path path="8" as="9" />
           <Path path="10" as="11" />
           <Path path="12" as="13" />
         </Paths>
       </Formula>
-      <Formula id="77405460-ed39-481b-9f55-1857229242d0" name="PARAM_pKa_pH_WS_sol_K6" dim="Dimensionless" formula="(1-F1)*F2*(1-F3)">
+      <Formula id="q19OAc-2IEitwwqwqisjJA" name="PARAM_pKa_pH_WS_sol_K6" formula="(1-F1)*F2*(1-F3)">
         <Paths>
           <Path path="8" as="9" />
           <Path path="10" as="11" />
           <Path path="12" as="13" />
         </Paths>
       </Formula>
-      <Formula id="402da265-25d6-4416-9d3a-4001088a3061" name="PARAM_pKa_pH_WS_sol_K7" dim="Dimensionless" formula="F1*(1-F2)*(1-F3)">
+      <Formula id="J-GLHfhTdkaWVR-lyMnR3g" name="PARAM_pKa_pH_WS_sol_K7" formula="F1*(1-F2)*(1-F3)">
         <Paths>
           <Path path="8" as="9" />
           <Path path="10" as="11" />
           <Path path="12" as="13" />
         </Paths>
       </Formula>
-      <Formula id="bb5c8e0e-95bb-4bc3-a233-ae80c72d802c" name="PARAM_pKa_pH_WS_sol_K8" dim="Dimensionless" formula="(1-F1)*(1-F2)*(1-F3)">
+      <Formula id="78-kbB0qc0CtHWLIQiWMnA" name="PARAM_pKa_pH_WS_sol_K8" formula="(1-F1)*(1-F2)*(1-F3)">
         <Paths>
           <Path path="8" as="9" />
           <Path path="10" as="11" />
           <Path path="12" as="13" />
         </Paths>
       </Formula>
-      <Formula id="cbd3e432-f7c0-4c31-894d-42ea90630201" name="PARAM_pKa_ThreeAcids_0" dim="Dimensionless" formula="IsTriproticAcid ? Min (pKa_0; Min (pKa_1; pKa_2)) : 0">
+      <Formula id="vHT9x5jzPEm5GXz_0oOFYQ" name="PARAM_pKa_ThreeAcids_0" formula="IsTriproticAcid ? Min (pKa_0; Min (pKa_1; pKa_2)) : 0">
         <Paths>
           <Path path="24" as="25" />
           <Path path="26" as="27" />
@@ -472,7 +799,7 @@
           <Path path="30" as="31" />
         </Paths>
       </Formula>
-      <Formula id="fa37f31b-967f-45d2-a76b-0eeecdba84fb" name="PARAM_pKa_ThreeAcids_1" dim="Dimensionless" formula="IsTriproticAcid ? (pKa_0 &lt;= pKa_Acid_0 ? min(pKa_1; pKa_2) : (pKa_0 &gt;= pKa_Acid_2 ? max(pKa_1; pKa_2) : pKa_0)) : 0">
+      <Formula id="v4oEcuuGzEC4KPs1famoqw" name="PARAM_pKa_ThreeAcids_1" formula="IsTriproticAcid ? (pKa_0 &lt;= pKa_Acid_0 ? min(pKa_1; pKa_2) : (pKa_0 &gt;= pKa_Acid_2 ? max(pKa_1; pKa_2) : pKa_0)) : 0">
         <Paths>
           <Path path="24" as="25" />
           <Path path="26" as="27" />
@@ -482,7 +809,7 @@
           <Path path="71" as="72" />
         </Paths>
       </Formula>
-      <Formula id="9bdded95-3c75-4628-b649-6fdf54dfd41f" name="PARAM_pKa_ThreeBases_0" dim="Dimensionless" formula="IsTriproticBase ? Min (pKa_0; Min (pKa_1; pKa_2)) : 0">
+      <Formula id="RPrfJEOyd0u4CcBIIb2hEA" name="PARAM_pKa_ThreeBases_0" formula="IsTriproticBase ? Min (pKa_0; Min (pKa_1; pKa_2)) : 0">
         <Paths>
           <Path path="45" as="46" />
           <Path path="26" as="27" />
@@ -490,7 +817,7 @@
           <Path path="30" as="31" />
         </Paths>
       </Formula>
-      <Formula id="f1efd166-55bf-45b7-8a54-2583b96c8cca" name="PARAM_pKa_ThreeBases_1" dim="Dimensionless" formula="IsTriproticBase ? (pKa_0 &lt;= pKa_Base_0 ? min(pKa_1; pKa_2) : (pKa_0 &gt;= pKa_Base_2 ? max(pKa_1; pKa_2) : pKa_0)) : 0">
+      <Formula id="Q-1Sy1dGj0qhtdiBpiCSvw" name="PARAM_pKa_ThreeBases_1" formula="IsTriproticBase ? (pKa_0 &lt;= pKa_Base_0 ? min(pKa_1; pKa_2) : (pKa_0 &gt;= pKa_Base_2 ? max(pKa_1; pKa_2) : pKa_0)) : 0">
         <Paths>
           <Path path="45" as="46" />
           <Path path="26" as="27" />
@@ -500,7 +827,7 @@
           <Path path="75" as="76" />
         </Paths>
       </Formula>
-      <Formula id="9f4eacd5-1fda-4a28-81b5-0c1cc676f6ff" name="PARAM_pKa_TwoAcids_1" dim="Dimensionless" formula="pKa_Acids_Count=2 ? (CT0 != CT_ACID ? Max(pKa_1;pKa_2) : (CT1 != CT_ACID ? Max(pKa_0;pKa_2) : Max(pKa_0;pKa_1))) : 0">
+      <Formula id="k4dwYQRYEEGdYiS5bqzvQA" name="PARAM_pKa_TwoAcids_1" formula="pKa_Acids_Count=2 ? (CT0 != CT_ACID ? Max(pKa_1;pKa_2) : (CT1 != CT_ACID ? Max(pKa_0;pKa_2) : Max(pKa_0;pKa_1))) : 0">
         <Paths>
           <Path path="0" as="1" />
           <Path path="2" as="3" />
@@ -511,7 +838,7 @@
           <Path path="20" as="21" />
         </Paths>
       </Formula>
-      <Formula id="8ac9f732-b720-44b7-b2d4-86e24cbf2a2b" name="PARAM_pKa_TwoBases_1" dim="Dimensionless" formula="pKa_Bases_Count=2 ? (CT0 != CT_BASE ? Max(pKa_1;pKa_2) : (CT1 != CT_BASE ? Max(pKa_0;pKa_2) : Max(pKa_0;pKa_1))) : 0">
+      <Formula id="8uBCH8bTCkWgOgtPqEqf7A" name="PARAM_pKa_TwoBases_1" formula="pKa_Bases_Count=2 ? (CT0 != CT_BASE ? Max(pKa_1;pKa_2) : (CT1 != CT_BASE ? Max(pKa_0;pKa_2) : Max(pKa_0;pKa_1))) : 0">
         <Paths>
           <Path path="0" as="1" />
           <Path path="2" as="3" />
@@ -522,7 +849,7 @@
           <Path path="22" as="23" />
         </Paths>
       </Formula>
-      <Formula id="1d7f0e1b-a6aa-43ab-91b8-ffa0f43fa938" name="PARAM_Solubility_pKa_RefpH_Factor" dim="Dimensionless" formula="K1+K2/base^(CT0^2)+K3/base^(CT1^2)+K4/base^(CT2^2)+K5/base^max(CT0+CT1;-CT0-CT1)+K6/base^max(CT0+CT2;-CT0-CT2)+K7/base^max(CT1+CT2;-CT1-CT2)+K8/base^max(CT0+CT1+CT2;-CT0-CT1-CT2)">
+      <Formula id="hl_xHXhJFE2Adq6jBGTSpA" name="PARAM_Solubility_pKa_RefpH_Factor" formula="K1+K2/base^(CT0^2)+K3/base^(CT1^2)+K4/base^(CT2^2)+K5/base^max(CT0+CT1;-CT0-CT1)+K6/base^max(CT0+CT2;-CT0-CT2)+K7/base^max(CT1+CT2;-CT1-CT2)+K8/base^max(CT0+CT1+CT2;-CT0-CT1-CT2)">
         <Paths>
           <Path path="0" as="1" />
           <Path path="2" as="3" />
@@ -538,7 +865,7 @@
           <Path path="93" as="94" />
         </Paths>
       </Formula>
-      <Formula id="fb4dc464-9921-4d36-95f5-087bf530204e" name="PARAM_pKa_TwoAcids_0" dim="Dimensionless" formula="pKa_Acids_Count=2 ? (CT0 != CT_ACID ? Min(pKa_1;pKa_2) : (CT1 != CT_ACID ? Min(pKa_0;pKa_2) : Min(pKa_0;pKa_1))) : 0">
+      <Formula id="2xsDcah1h0iQ7F5tc_jRlA" name="PARAM_pKa_TwoAcids_0" formula="pKa_Acids_Count=2 ? (CT0 != CT_ACID ? Min(pKa_1;pKa_2) : (CT1 != CT_ACID ? Min(pKa_0;pKa_2) : Min(pKa_0;pKa_1))) : 0">
         <Paths>
           <Path path="0" as="1" />
           <Path path="2" as="3" />
@@ -549,110 +876,52 @@
           <Path path="20" as="21" />
         </Paths>
       </Formula>
-      <Formula id="95ea7e0e-7821-4825-9019-549a4a893785" name="PARAM_P" dim="Velocity" formula="IsSmallMolecule ? (MWEff / 336) ^ (-6) * 10^LogMA / 5 * 1E-4 : 0">
+      <Formula id="ST9ewPUpnE-YK8yV_YQilg" name="PARAM_P" dim="Velocity" formula="IsSmallMolecule ? (MWEff *1E9 / 336) ^ (-6) * 10^LogMA / 5 * 1E-4 *1E-1: 0">
         <Paths>
           <Path path="95" as="96" dim="67" />
           <Path path="97" as="98" />
           <Path path="99" as="100" dim="101" />
         </Paths>
       </Formula>
-      <Formula id="2e21b031-4150-413c-8bfe-428d023baf36" name="PARAM_P_int_InVitro" dim="Velocity" formula="IsSmallMolecule ? (266 * (MWEff ^ ( - 4.5) * 10^LogMA))*60 : 0">
+      <Formula id="MHOQGqWip0qzqqfWs4Av6A" name="PARAM_P_int_InVitro" dim="Velocity" formula="IsSmallMolecule ? 266 * (MWEff * 1E9) ^ ( - 4.5) * 10^LogMA * 60 *1E-1 : 0">
         <Paths>
           <Path path="95" as="96" dim="67" />
           <Path path="97" as="98" />
           <Path path="99" as="100" dim="101" />
         </Paths>
       </Formula>
-      <Formula id="560afe24-0801-4366-90e5-6a213de72ffd" name="PARAM_KProt" dim="Dimensionless" formula="(0.81 + 0.11 * 10^LogMA) / 24.92 * 5.0">
+      <Formula id="et_Z9z3qrUWQWf_K67ihbA" name="PARAM_KProt" formula="(0.81 + 0.11 * 10^LogMA) / 24.92 * 5.0">
         <Paths>
           <Path path="99" as="100" dim="101" />
         </Paths>
       </Formula>
-      <Formula id="ecf1d1dd-0642-4c4a-821d-46f238cc8c73" name="PARAM_Aqueous_diffusion_coefficient" dim="DiffusionCoefficient" formula="60 * 10^(-4.113-0.4609*Log10(MW))">
+      <Formula id="txSvdn3Qi0eFz57EAQowQg" name="PARAM_Aqueous_diffusion_coefficient" dim="Diffusion coefficient" formula="60 * 10^(-4.113-0.4609*Log10(MW * 1E9)) *1E-2">
         <Paths>
           <Path path="65" as="66" dim="67" />
         </Paths>
       </Formula>
-      <Formula id="9afe72f6-8ce0-430b-981c-6281f680de9f" name="PARAM_Ae" dim="Nanolength" formula="0,0333 * MW ^ 0,4226">
+      <Formula id="D6SIvwugH0GMrd80Qqztiw" name="PARAM_Ae" dim="Length" formula="0,0333 * (MW * 1E9) ^ 0,4226 * 1E-8">
         <Paths>
           <Path path="65" as="66" dim="67" />
         </Paths>
       </Formula>
-      <Formula id="e1406baf-c159-4aba-92f0-080bc51c5a56" name="ConcFormula" dim="MolarConcentration" formula="M/V">
+      <Formula id="KS0RvhqdkE6iSD9ZCkuaQA" name="ConcFormula" dim="Concentration (molar)" formula="M/V">
         <Paths>
           <Path path="102" as="103" dim="104" />
           <Path path="105" as="106" dim="107" />
         </Paths>
       </Formula>
-      <ConstantFormula id="618eef56-7722-4f75-965c-8d022a8c2a59" dim="MolecularWeight" value="400" />
-      <ConstantFormula id="aba61122-eb22-4acf-bbbc-15a50afc6d10" dim="Dimensionless" value="0" />
-      <ConstantFormula id="b9593c99-6170-48ea-ad27-af5e154fceea" dim="Dimensionless" value="0" />
-      <ConstantFormula id="8ea3dd2b-2269-4ee3-8e68-82107cccfc16" dim="Dimensionless" value="0" />
-      <ConstantFormula id="d7f1091c-e77b-4fe0-9338-a15e0c445b4d" dim="Dimensionless" value="0" />
-      <ConstantFormula id="147990d4-a6ad-433e-82d2-1660c1ce01d4" dim="Dimensionless" value="-1" />
-      <ConstantFormula id="a2ae4fcd-4eed-4f6f-b1e7-e6582de15cb5" dim="Dimensionless" value="1" />
-      <ConstantFormula id="aadd817c-094a-4cfb-851e-970a7ca898c5" dim="Dimensionless" value="0" />
-      <ConstantFormula id="e264fd18-e374-40a3-bc28-1984ed5ff212" dim="Dimensionless" value="0" />
-      <ConstantFormula id="521446e0-b2c6-4375-9915-5da47993b1e6" dim="Dimensionless" value="0" />
-      <ConstantFormula id="37466c4f-aab5-4555-b551-e396eecef155" dim="MolarConcentration" value="1" />
-      <ConstantFormula id="a197b9b3-776f-46ad-89d0-696bc00e08ea" dim="MolarConcentration" value="1" />
-      <ConstantFormula id="724e229b-dd56-4945-ad5e-5cd2a340e492" dim="Dimensionless" value="0" />
-      <ConstantFormula id="21eea311-5783-49f3-bd2a-7ddcafa488f4" dim="Dimensionless" value="0" />
-      <ConstantFormula id="9f2a9f1a-0f43-489d-84e8-cea53bfbe65c" dim="Dimensionless" value="0" />
-      <ConstantFormula id="4bee111b-6310-432d-b1e1-ae79dfec0ec1" dim="Dimensionless" value="0" />
-      <ConstantFormula id="0ee8360a-3ba3-4a42-a7e1-07934cabad9f" dim="Dimensionless" value="20" />
-      <ConstantFormula id="d6efbfab-0198-47a9-90c2-529ea9004292" dim="Dimensionless" value="0.001" />
-      <ConstantFormula id="b0f1f832-4cd7-40a7-a5d0-a89eae4b7d82" dim="Dimensionless" value="0.001" />
-      <ConstantFormula id="f0ebb3e5-3a68-41ad-a5d4-e1e2a39d60be" dim="Dimensionless" value="0.1" />
-      <ConstantFormula id="0fb0d6d8-d1a8-4165-a6ab-241525e2fd43" dim="Dimensionless" value="0" />
-      <ConstantFormula id="9b164e8f-d30d-4662-b8c1-3af37bfaa6f9" dim="Lipophilicity" value="3" />
-      <ConstantFormula id="19c0252d-bfc6-44e2-9a99-6e2f515f5aba" dim="Fraction" value="0.1" />
-      <ConstantFormula id="68c0d685-8d53-45db-b8d9-c50fdf78251f" dim="Concentration" value="9999000" />
-      <ConstantFormula id="ccaea30a-61a3-497e-a44e-20d380b63b83" dim="Dimensionless" value="7" />
-      <ConstantFormula id="a0a16c90-9702-4c12-bd15-0ffe67c68b8a" dim="Dimensionless" value="1000" />
-      <ConstantFormula id="144daa8f-c630-4b32-822a-44e7693f7135" dim="Dimensionless" value="1" />
-      <ConstantFormula id="a6006406-3d70-409f-8e4f-6e4752f59efa" dim="Density" value="1" />
-      <ConstantFormula id="dc3cde42-2729-4533-9a0a-e7e08f63ea0c" dim="Nanolength" value="10" />
-      <ConstantFormula id="032f5c87-ac58-4a59-bae7-151c650eaff2" dim="MolarConcentration" value="999999" />
-      <ConstantFormula id="8b7c4adc-a4b0-4306-be2d-387331cff826" dim="Dimensionless" value="0" />
-      <ConstantFormula id="a4bf0961-d8d6-4e96-9654-79991ec47f31" dim="Dimensionless" value="0" />
-      <ConstantFormula id="3695e1ef-8108-4afd-b60f-64a1f9e44a90" dim="Density" value="0" />
-      <ConstantFormula id="9f249c31-8c68-4dde-9b4a-4324bb1dcc42" dim="Rate" value="1" />
-      <ConstantFormula id="730bc622-6fdb-4113-a1be-74479331b8bf" dim="Amount" value="0" />
-      <ConstantFormula id="0c95604c-10fb-40d2-b879-6a886317e4e8" dim="Rate" value="0" />
-      <ConstantFormula id="3f93d61b-72e8-4f3b-b2eb-e8efab1d0986" dim="SpecificClearancePerProtein" value="1" />
-      <ConstantFormula id="8e3feaf7-f9b1-4530-86a6-a243e329a360" dim="Dimensionless" value="20" />
-      <ConstantFormula id="e114303f-5610-4824-b606-714265fec9b1" dim="Dimensionless" value="0.001" />
-      <ConstantFormula id="415942b5-7e13-4071-92ec-c577cf0b2191" dim="Dimensionless" value="0.001" />
-      <ConstantFormula id="0acb637a-38ce-4acf-b81d-d2b714073353" dim="Dimensionless" value="0.1" />
-      <ConstantFormula id="154bf5c8-4f5b-4e00-a590-c3eaf7917728" dim="Dimensionless" value="0" />
-      <ConstantFormula id="326cf200-b6e7-4c1e-9eb6-506084d02d35" dim="Dimensionless" value="0" />
-      <ConstantFormula id="cacca64d-774e-4d1e-8f86-8b90015b649b" dim="Dimensionless" value="0" />
-      <ConstantFormula id="aebafb5f-66b2-456d-83ca-3f3dd43f980a" dim="Dimensionless" value="0" />
-      <ConstantFormula id="354e60d6-2cdc-409d-a47c-c4d8d02eae26" dim="Dimensionless" value="0" />
-      <ConstantFormula id="df1b5e59-6b80-4ca6-89f1-cc34fc214af8" dim="Dimensionless" value="-1" />
-      <ConstantFormula id="7da0517f-c940-4b2f-851d-be1932ff2ee2" dim="Dimensionless" value="1" />
-      <ConstantFormula id="47150fcb-c5ee-4fc7-b27d-ca81acf12ae3" dim="Dimensionless" value="0" />
-      <ConstantFormula id="2b198812-7b54-4d0e-a6cd-1838f3c06d00" dim="Density" value="1" />
-      <ConstantFormula id="a13ce15f-4da5-4083-88d5-0a5b0b872312" dim="Dimensionless" value="0" />
-      <ConstantFormula id="59c2e06c-9d9c-4d22-8b8c-b4ec14bbda79" dim="Fraction" value="0.1" />
-      <ConstantFormula id="e4579c4c-412e-4b77-901f-bf1c6f301066" dim="Dimensionless" value="0" />
-      <ConstantFormula id="06499842-026e-42d5-8faf-8338daded2c7" dim="Nanolength" value="10" />
-      <ConstantFormula id="c3c57024-3308-4cc7-8372-3a498634ead6" dim="MolarConcentration" value="1" />
-      <ConstantFormula id="4d0952f5-99e6-40ef-8103-45190d399873" dim="MolarConcentration" value="1" />
-      <ConstantFormula id="af5c060d-b433-491d-93c8-beb1b785ea4a" dim="MolarConcentration" value="999999" />
-      <ConstantFormula id="0e1e86da-35a7-4cf7-802e-66b42b2a285f" dim="Lipophilicity" value="3" />
-      <ConstantFormula id="962377f5-2e59-4bd0-8434-0a53305fb5e1" dim="MolecularWeight" value="400" />
-      <ConstantFormula id="70d4ae9f-89f7-4dbf-b378-a0122557bdf4" dim="Dimensionless" value="0" />
-      <ConstantFormula id="8599775f-1cfc-4e49-aac9-5e8d21582aa0" dim="Dimensionless" value="0" />
-      <ConstantFormula id="4bf5cd13-f890-48bc-a749-c7849f209e1c" dim="Dimensionless" value="0" />
-      <ConstantFormula id="2785b8c0-2e50-4f79-9942-bfb342bb8ccb" dim="Dimensionless" value="7" />
-      <ConstantFormula id="5a6c5770-8b03-493e-838e-f2b2886ede81" dim="Concentration" value="9999000" />
-      <ConstantFormula id="b6a217e0-8372-417c-bb5f-074803a0da73" dim="Dimensionless" value="1000" />
-      <ConstantFormula id="bba2067d-2c4c-4db4-851d-d41cbb10baaf" dim="Dimensionless" value="0" />
-      <ConstantFormula id="f563d5be-24e3-4a71-a709-1fd8548fed1d" dim="Dimensionless" value="1" />
-      <ConstantFormula id="7d8211a1-d9af-4dbd-a46f-1fd657edf128" dim="Dimensionless" value="0" />
-      <ConstantFormula id="83dbf546-64c7-4137-b0f0-08f9af5e69ce" dim="Amount" value="0" />
+      <SumFormula id="oosTscPgCUiJqQI_z4d_Ig" name="PARAM_TotalDrugMass" dim="Amount" variable="P" formulaString="P_#i">
+        <Criteria>
+          <DescriptorConditions>
+            <MatchTagCondition tag="MOLECULE" />
+            <MatchTagCondition tag="DrugMass" />
+          </DescriptorConditions>
+        </Criteria>
+      </SumFormula>
+      <ConstantFormula id="1lvsN49MrUCRR_VWS4Pjlg" value="0" />
+      <ConstantFormula id="v4W_hJAbLky9Jzr07Esaiw" dim="Amount" value="0" />
+      <ConstantFormula id="afdoe1RXi06lyfYL9riUFQ" dim="Amount" value="0" />
     </Formulas>
     <StringMap>
       <Map s="..|Compound type 0" id="0" />
@@ -722,7 +991,7 @@
       <Map s="I" id="64" />
       <Map s="..|Molecular weight" id="65" />
       <Map s="MW" id="66" />
-      <Map s="MolecularWeight" id="67" />
+      <Map s="Molecular weight" id="67" />
       <Map s="Chlor" id="68" />
       <Map s="..|pKa_Acid_0" id="69" />
       <Map s="pKa_Acid_0" id="70" />
@@ -756,7 +1025,7 @@
       <Map s="IsSmallMolecule" id="98" />
       <Map s="..|Lipophilicity" id="99" />
       <Map s="LogMA" id="100" />
-      <Map s="Lipophilicity" id="101" />
+      <Map s="Log Units" id="101" />
       <Map s=".." id="102" />
       <Map s="M" id="103" />
       <Map s="Amount" id="104" />
diff --git a/tests/MoBi.Tests/TestFiles/PK_Manual_Diclofenac.mbp3 b/tests/MoBi.Tests/TestFiles/PK_Manual_Diclofenac.mbp3
index d1f5bf8a1..cb897fdd5 100644
Binary files a/tests/MoBi.Tests/TestFiles/PK_Manual_Diclofenac.mbp3 and b/tests/MoBi.Tests/TestFiles/PK_Manual_Diclofenac.mbp3 differ
diff --git a/tests/MoBi.Tests/TestFiles/Passive Transports.pkml b/tests/MoBi.Tests/TestFiles/Passive Transports.pkml
index 23335d18d..4e3e51029 100644
--- a/tests/MoBi.Tests/TestFiles/Passive Transports.pkml	
+++ b/tests/MoBi.Tests/TestFiles/Passive Transports.pkml	
@@ -1,15 +1,18 @@
 <?xml version="1.0" encoding="utf-8"?>
-<PassiveTransportBuildingBlock id="4f26635c-b577-4279-ab93-be8cc8967674" name="Passive Transports" bbVersion="2" version="3">
+<PassiveTransportBuildingBlock id="p3neKtXLakOrRZZRkMi5lQ" name="Passive Transports" icon="PassiveTransport" bbVersion="2" version="13">
+  <Creation createdAt="5248846133806172061" createdBy="Michael" creationMode="New" origin="Other" />
   <Builders>
-    <TransportBuilder id="7dd8ec32-3bba-4532-9e8c-546544626dbd" name="PassiveTransport" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="8c095700-2229-4a26-a75e-4b708c20af8a" transportType="0">
+    <TransportBuilder id="oVIFCJ5QeUmb2dmkS5TUoQ" name="PassiveTransport" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="jeoTYEpJr0y_p8_hk3J1Gg" transportType="0">
       <Children>
-        <Parameter id="4f9fc8f7-ac53-4f05-a633-7eaa413abcee" name="K" persistable="0" isFixedValue="0" dim="Second order rate constant" quantityType="Parameter" visible="1" canBeVaried="1" value="0.4" displayUnit="l/µmol/min" />
+        <Parameter id="375QeKIKgUmE9BH2jq4eXQ" name="K" icon="Parameter" persistable="0" isFixedValue="0" dim="Second order rate constant" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.4" displayUnit="l/µmol/min">
+          <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+        </Parameter>
       </Children>
       <SourceCriteria />
       <TargetCriteria />
       <MoleculeList forAll="1" />
     </TransportBuilder>
-    <TransportBuilder id="7a981397-5e21-469e-89ff-488b9070a35a" name="GallbladderEmptying" mode="Logical" containerType="Other" dimension="Rate" createProcessRateParameter="0" processRateParameterPersistable="0" formula="73f97cbf-9598-4e80-8298-4b80b326b223" transportType="0">
+    <TransportBuilder id="L9wPWtH6OU6D2FMrj2ZvZA" name="GallbladderEmptying" mode="Logical" containerType="Other" dimension="Rate" createProcessRateParameter="0" processRateParameterPersistable="0" formula="zJ6Rj4LPT02_V2sEqDG1xw" transportType="0">
       <SourceCriteria>
         <DescriptorConditions>
           <MatchTagCondition tag="Gallbladder" />
@@ -26,17 +29,27 @@
   </Builders>
   <FormulaCache>
     <Formulas>
-      <Formula id="73f97cbf-9598-4e80-8298-4b80b326b223" name="GallbladderEmptyingRate" dim="Rate" formula="GallbladderEmptyingRate">
+      <Formula id="zJ6Rj4LPT02_V2sEqDG1xw" name="GallbladderEmptyingRate" dim="Rate" formula="EHC_Active ? ln(2) / EHC_Halftime * M * EHC_EjectionFraction : 0">
         <Paths>
           <Path path="0" as="1" dim="2" />
+          <Path path="3" as="4" />
+          <Path path="5" as="6" dim="2" />
+          <Path path="7" as="8" dim="9" />
         </Paths>
       </Formula>
-      <ConstantFormula id="8c095700-2229-4a26-a75e-4b708c20af8a" dim="Amount per time" value="0" />
+      <ConstantFormula id="jeoTYEpJr0y_p8_hk3J1Gg" dim="Amount per time" value="0" />
     </Formulas>
     <StringMap>
-      <Map s="Organism|Gallbladder|Gallbladder emptying rate" id="0" />
-      <Map s="GallbladderEmptyingRate" id="1" />
-      <Map s="Rate" id="2" />
+      <Map s="Organism|Gallbladder|MOLECULE" id="0" />
+      <Map s="M" id="1" />
+      <Map s="Amount" id="2" />
+      <Map s="Organism|Gallbladder|Gallbladder emptying active" id="3" />
+      <Map s="EHC_Active" id="4" />
+      <Map s="Organism|Gallbladder|Gallbladder ejection fraction" id="5" />
+      <Map s="EHC_EjectionFraction" id="6" />
+      <Map s="Organism|Gallbladder|Gallbladder ejection half-time" id="7" />
+      <Map s="EHC_Halftime" id="8" />
+      <Map s="Time" id="9" />
     </StringMap>
   </FormulaCache>
 </PassiveTransportBuildingBlock>
\ No newline at end of file
diff --git a/tests/MoBi.Tests/TestFiles/Sim.pkml b/tests/MoBi.Tests/TestFiles/Sim.pkml
new file mode 100644
index 000000000..c969880bb
--- /dev/null
+++ b/tests/MoBi.Tests/TestFiles/Sim.pkml
@@ -0,0 +1,70318 @@
+<?xml version="1.0" encoding="utf-8"?>
+<SimulationTransfer id="g1WPlDqcW0-uRUgoqV0fuw" version="13">
+  <Simulation id="2cIiSNq2XE-AmhtOh6ANjQ" name="Sim" icon="Simulation">
+    <BuildConfiguration>
+      <Molecules id="og4quk0DMUe-X8L8UxguIw" name="Sim" icon="Molecule" bbVersion="0">
+        <Creation createdAt="5248777815990464860" createdBy="Michael" creationMode="New" origin="PKSim" version="9.0" internalVersion="77" />
+        <Builders>
+          <MoleculeBuilder id="41c6u5N07UiWrj-7avfs3A" name="CYP344" icon="ENZYME" mode="Logical" containerType="Other" isFloating="0" quantityType="Enzyme" isXenobiotic="0" dim="Amount" defaultStartFormula="9Bpm4mXN3kCeacGHBDElvA" displayUnit="µmol">
+            <Children>
+              <Parameter id="yiXQcmG3uUGP-HligHppYg" name="Degradation coefficient" description="First order turnover rate constant of the enzyme" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="9TQNaU_m3kKEQgJgSoOb5w" isDefault="1" displayUnit="1/min">
+                <ValueOrigin id="33" source="Other" description="OSP Suite Manual Chapter 16. PK-Sim®- Compounds: Defining inhibition/induction processes" />
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="91" />
+              </Parameter>
+              <Parameter id="0BrduNB-hEm_BwKvtrYVdg" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Global" isDefault="1" value="1">
+                <Info min="0" flag="58" seq="1" ref="0" bb="32" group="142" />
+              </Parameter>
+              <Parameter id="l3DWl3b7vUOQhDmzAjefXQ" name="Ontogeny factor GI" description="Ontogeny factor GI" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Global" isDefault="1" value="1">
+                <Info min="0" flag="58" seq="1" ref="0" bb="32" group="142" />
+              </Parameter>
+              <Parameter id="8bFNZQhLNkiTdjBEHa9Q8g" name="Reference concentration" description="CYP Form | [pmol/mg HLM] | [µmol CYP/l Liver tissue]&#xD;&#xA;CYP1A2 | 45 | 1.8&#xD;&#xA;CYP2A6 | 68 | 2.72&#xD;&#xA;CYP2B6 | 39 | 1.56&#xD;&#xA;CYP2C18 | &lt;2,5 | &lt;0,1&#xD;&#xA;CYP2C19 | 19 | 0.76&#xD;&#xA;CYP2C8 | 64 | 2.56&#xD;&#xA;CYP2C9 | 96 | 3.84&#xD;&#xA;CYP2D6 | 10 | 0.4&#xD;&#xA;CYP2E1 | 49 | 1.96&#xD;&#xA;CYP3A4 | 108 | 4.32&#xD;&#xA;CYP3A5 | 1 | 0.04&#xD;&#xA;Source: Rodrigues (1999), Table2" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Global" isDefault="1" value="1" displayUnit="µmol/l">
+                <Info min="0" flag="122" seq="1" ref="0" bb="32" group="91" />
+              </Parameter>
+              <Parameter id="DsrbwxY0YUqJEdSw4gkOLw" name="Rel. exp. variability factor" description="Variability factor for relative expressions" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Global" isDefault="1" value="1">
+                <Info min="0" flag="54" seq="1" ref="0" bb="32" group="91" />
+              </Parameter>
+              <Parameter id="MHNCJ2ymbUizFrCzRbMfwA" name="Relative expression" description="Relative expression" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0">
+                <Info min="0" flag="60" seq="1" ref="0" bb="2" group="91" />
+              </Parameter>
+              <Parameter id="hOUZAcC2fkq9J9md5YVXJg" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0">
+                <Info min="0" flag="58" seq="1" ref="0" bb="2" group="91" />
+              </Parameter>
+              <Parameter id="AJu5KqRztkuSH1zJf_f6ZA" name="Relative expression in blood cells" description="Relative expression in blood cells" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Global" isDefault="1" value="0">
+                <Info min="0" flag="60" seq="1" ref="0" bb="2" group="91" />
+              </Parameter>
+              <Parameter id="MK9Y3TuKiUm8ZK9TIdlBTg" name="Relative expression in blood cells (normalized)" description="Relative expression norm in blood cells" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Global" isDefault="1" value="0">
+                <Info min="0" flag="58" seq="1" ref="0" bb="2" group="91" />
+              </Parameter>
+              <Parameter id="5eiTZpsyl0S4WLLuHCUJ7Q" name="Relative expression out." description="Relative Expression that will be used in the simulation" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0">
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="91" />
+              </Parameter>
+              <Parameter id="fj3RnmGxOkOyajVM_fdo1g" name="Start amount" description="Start amount of molecule" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" formula="G9k8FErhtUCRQAcBa2fsUA" isDefault="1" displayUnit="µmol">
+                <Info flag="54" seq="1" ref="0" bb="2" group="91" />
+              </Parameter>
+              <Parameter id="gKmGrK2L2EOlzzO56eJv_A" name="t1/2 (intestine)" description="Half-life of drug release in the intestine" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Global" isDefault="1" value="1380" displayUnit="h">
+                <Info min="0" flag="106" seq="1" ref="0" bb="32" group="91" />
+              </Parameter>
+              <Parameter id="mIko6fW0IkqHwyzrogK-bg" name="t1/2 (liver)" description="Half-life of drug release in the liver" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Global" isDefault="1" value="2160" displayUnit="h">
+                <Info min="0" flag="106" seq="1" ref="0" bb="32" group="91" />
+              </Parameter>
+              <Parameter id="Qs5x0h9jv0WnjwqzfFYaGw" name="Relative expression in plasma" description="Relative expression in plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Global" isDefault="1" value="0">
+                <Info min="0" flag="60" seq="2" ref="0" bb="2" group="91" />
+              </Parameter>
+              <Parameter id="mf-BnGKWZEa665ygFIyetg" name="Relative expression in plasma (normalized)" description="Relative expression norm in plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Global" isDefault="1" value="0">
+                <Info min="0" flag="58" seq="2" ref="0" bb="2" group="91" />
+              </Parameter>
+              <Parameter id="qaGfkCe--EeTv-EpYpPtNg" name="Relative expression in vascular endothelium" description="Relative expression in vasc. Endothelium" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Global" isDefault="1" value="0">
+                <Info min="0" flag="60" seq="3" ref="0" bb="2" group="91" />
+              </Parameter>
+              <Parameter id="e9pSAQPGMEy-e-P4TlCkew" name="Relative expression in vascular endothelium (normalized)" description="Relative expression in vasc. Endothelium" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Global" isDefault="1" value="0">
+                <Info min="0" flag="58" seq="3" ref="0" bb="2" group="91" />
+              </Parameter>
+              <Parameter id="NcgPbr1BfEW3jkKPV71JQw" name="base_For_KaPL_Factor" description="Supporting parameter for calculation of pKa- and pH- dependent values of KaPL" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="20">
+                <ValueOrigin id="34" source="Publication" description="Toxicol In Vitro. 2008 Mar;22(2):457-67 https://doi.org/10.1016/j.tiv.2007.09.010" />
+                <Info min="0" flag="36" seq="1" ref="0" bb="2" group="16" />
+              </Parameter>
+              <Parameter id="vRUZBzKPLEOTT4jnjXrirg" name="base_For_logD_Factor" description="Supporting parameter for calculation of pKa- and pH- dependent logD" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0.001">
+                <ValueOrigin id="34" source="Publication" description="Toxicol In Vitro. 2008 Mar;22(2):457-67 https://doi.org/10.1016/j.tiv.2007.09.010" />
+                <Info min="0" flag="36" seq="1" ref="0" bb="2" group="16" />
+              </Parameter>
+              <Parameter id="09kdHNPfjE2aoSmo-qIRiw" name="base_For_P_cell_Factor" description="Supporting parameter for calculation of pKa- and pH- dependent permeability to/from cells" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0.001">
+                <Info min="0" flag="36" seq="1" ref="0" bb="2" group="16" />
+              </Parameter>
+              <Parameter id="c1PKm3cn1EywLMdUDoTWEQ" name="base_For_Pint_Factor" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0.1">
+                <Info min="0" flag="36" seq="1" ref="0" bb="2" group="16" />
+              </Parameter>
+              <Parameter id="NhPblvBFD0SvCoOFyn3o9g" name="BP_AGP" description="Constant for binding partner α1-acid glycoprotein" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0">
+                <Info flag="52" seq="1" ref="0" bb="2" group="9" />
+              </Parameter>
+              <Parameter id="ycJPwlMXjkCcJCVNlsupKw" name="BP_ALBUMIN" description="Constant for binding partner albumin" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="1">
+                <Info flag="52" seq="1" ref="0" bb="2" group="9" />
+              </Parameter>
+              <Parameter id="T-gZanrRlky07mopmqVdmA" name="BP_UNKNOWN" description="Constant for binding partner unknown" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="2">
+                <Info flag="52" seq="1" ref="0" bb="2" group="9" />
+              </Parameter>
+              <Parameter id="YIicjNstqUChY8CMte-rSw" name="Br" description="Number of bromine atoms in molecule" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0">
+                <Info min="0" max="10" flag="50" seq="1" ref="0" bb="2" group="13" />
+              </Parameter>
+              <Parameter id="Db2yNlbsN0uiABMOXL314Q" name="Calculated specific intestinal permeability (transcellular)" description="Calculated specific intestinal permeability (transcellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="g2Hl-6SB90uX7RRzAnZRew" buildMode="Global" isDefault="1" displayUnit="cm/min">
+                <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="RN0Pcld_x06EZUZZJ5g52w" name="Cl" description="Number of chlorine atoms in molecule" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0">
+                <Info min="0" max="10" flag="50" seq="1" ref="0" bb="2" group="13" />
+              </Parameter>
+              <Parameter id="Xfy1xA3zVkiBW1bzkVuBsQ" name="Compound type 0" description="Compound type (-1: acid, +1: base, 0: neutral)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0">
+                <Info min="-1" max="1" flag="50" seq="1" ref="0" bb="2" group="16" />
+              </Parameter>
+              <Parameter id="MvKovarGQ0u56AT0U3Z_jQ" name="Compound type 1" description="Compound type (-1: acid, +1: base, 0: neutral)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0">
+                <Info min="-1" max="1" flag="50" seq="1" ref="0" bb="2" group="16" />
+              </Parameter>
+              <Parameter id="TzJZilxRr0mWsDz-vx3ycg" name="Compound type 2" description="Compound type (-1: acid, +1: base, 0: neutral)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0">
+                <Info min="-1" max="1" flag="50" seq="1" ref="0" bb="2" group="16" />
+              </Parameter>
+              <Parameter id="qhg88UXK0kWxzGAkYfihFQ" name="CT_ACID" description="Constant for compound type acid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="-1">
+                <Info min="-1" max="-1" flag="52" seq="1" ref="0" bb="2" group="16" />
+              </Parameter>
+              <Parameter id="wG05iTYSoEKoHUlvBiq1aw" name="CT_BASE" description="Constant for compound type base" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="1">
+                <Info min="1" max="1" flag="52" seq="1" ref="0" bb="2" group="16" />
+              </Parameter>
+              <Parameter id="3myh64RedUa8T_fCj383Zw" name="CT_NEUTRAL" description="Constant for compound type neutral" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0">
+                <Info min="0" max="0" flag="52" seq="1" ref="0" bb="2" group="16" />
+              </Parameter>
+              <Parameter id="VaBfYdPb_0ipQ47PxE3HRw" name="Effective molecular weight" description="Effective molecular weight" icon="Parameter" persistable="0" isFixedValue="0" dim="Molecular weight" quantityType="Parameter" negativeValuesAllowed="1" formula="bjrJlspJx0CVb0sqctCXhw" buildMode="Property" isDefault="1" displayUnit="g/mol">
+                <ValueOrigin id="25" source="Publication" description="Stefan Willmann, Walter Schmitt,Jörg Keldenich, Jörg Lippert, and Jennifer B. Dressman: A Physiological Model for the Estimation of the Fraction Dose Absorbed in Humans. J. Med. Chem. 2004, 47, 4022-4031" />
+                <Info min="1.5E-08" flag="54" seq="1" ref="0" bb="2" group="13" />
+              </Parameter>
+              <Parameter id="e7JMsYsxzEaNfkgEKGE4Cw" name="F" description="Number of fluorine atoms in molecule" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0">
+                <Info min="0" max="10" flag="50" seq="1" ref="0" bb="2" group="13" />
+              </Parameter>
+              <Parameter id="E1guEhTDi0icRKqYYI-Rkw" name="Has halogens" description="Supporting parameter for compound" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="eDrmMuaBIEWvXE2zKj6jCw" buildMode="Property" isDefault="1">
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="13" />
+              </Parameter>
+              <Parameter id="LqbQuuaFfkS3mqetCeFZbw" name="I" description="Number of iodine atoms in molecule" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0">
+                <Info min="0" max="10" flag="50" seq="1" ref="0" bb="2" group="13" />
+              </Parameter>
+              <Parameter id="5PosmLI5wkKgMsM3X__UxQ" name="Is diprotic acid" description="Is diprotic acid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="O0Ygj5BtsUmaMSiCQ2BA2w" buildMode="Property" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="16" />
+              </Parameter>
+              <Parameter id="HPr06ZJ3XEy7OYO6nw7Aiw" name="Is diprotic base" description="Is diprotic base" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="LBv9JCs2O0-e4Rea2Qhb2A" buildMode="Property" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="16" />
+              </Parameter>
+              <Parameter id="58UCfMPMpkuXNyqOr7eOoQ" name="Is diprotic base monoprotic acid" description="Is diprotic base monoprotic acid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IOi-kI6sskuhyfzxHybZ_A" buildMode="Property" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="16" />
+              </Parameter>
+              <Parameter id="6VGVrmWoOUKfP7kh7YqGyA" name="Is floating in lumen" description="Is floating in lumen" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="9" />
+              </Parameter>
+              <Parameter id="DSAGrMTGm0qrEktT1kse9w" name="Is monoprotic acid" description="Is monoprotic acid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="1NjeU1paL0Wl3efDoSLREw" buildMode="Property" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="16" />
+              </Parameter>
+              <Parameter id="j97H5SumiE-ILYoeeKXczQ" name="Is monoprotic base" description="Is monoprotic base" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Ezm2VQdJT06z4p1RJr89Xg" buildMode="Property" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="16" />
+              </Parameter>
+              <Parameter id="e8y5i1qhQk-dNVmNcma3qQ" name="Is monoprotic base diprotic acid" description="Is monoprotic base diprotic acid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CwKTESVg_0OHyq4gXSiKLA" buildMode="Property" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="16" />
+              </Parameter>
+              <Parameter id="mhTpObCJQUOWxcoSgk282Q" name="Is monoprotic base monoprotic acid" description="Is monoprotic base monoprotic acid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="NnE3JQPE1UuvApxiOd8wEw" buildMode="Property" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="16" />
+              </Parameter>
+              <Parameter id="zXOltbQZI0qVq_4FHaLmqw" name="Is neutral" description="Supporting parameter for partition coeffs in RR-Modell" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="0UdLvHK2PU2xFuUkIbBCGw" buildMode="Property" isDefault="1">
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="16" />
+              </Parameter>
+              <Parameter id="ZdhXkD2YCESweeq816492A" name="Is small molecule" description="Treat compound as small molecule or not (if not, both organ specific and intestinal permeability will be set to zero)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="9" />
+              </Parameter>
+              <Parameter id="XsO8VBTKP0el__0_tFzVRA" name="Is strong base" description="Supporting parameter for partition coeffs in RR-Modell (at least one basic pKa&gt;=7)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CbDAqBiHk0aGzu-AaQOI_g" buildMode="Property" isDefault="1">
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="16" />
+              </Parameter>
+              <Parameter id="DbzNe9ly4k-fWixoSRTEhQ" name="Is triprotic acid" description="Is triprotic acid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="NfIRysJkWUu9n8E9oEfRjQ" buildMode="Property" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="16" />
+              </Parameter>
+              <Parameter id="Al2TEfR_ME2OiAYjGpLP1w" name="Is triprotic base" description="Is triprotic base" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="tH4SauLaaE2EhlcuiRWwCQ" buildMode="Property" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="16" />
+              </Parameter>
+              <Parameter id="obpa8cKMlke3fOTpz_79eg" name="Molecular weight" description="Molecular weight" icon="Parameter" persistable="0" isFixedValue="0" dim="Molecular weight" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="NaN" displayUnit="g/mol">
+                <Info min="1.5E-08" flag="48" seq="1" ref="0" bb="2" group="13" />
+              </Parameter>
+              <Parameter id="wQwoZ-KP70qgyBjU2n9sMw" name="pKa value 0" description="pKa value" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0">
+                <Info min="0" max="14" flag="50" seq="1" ref="0" bb="2" group="16" />
+              </Parameter>
+              <Parameter id="fAwaMYee6kaHgXk-85A06Q" name="pKa value 1" description="pKa value" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0">
+                <Info min="0" max="14" flag="50" seq="1" ref="0" bb="2" group="16" />
+              </Parameter>
+              <Parameter id="5nS49hAPfE-cn2YFJ_JQYg" name="pKa value 2" description="pKa value" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0">
+                <Info min="0" max="14" flag="50" seq="1" ref="0" bb="2" group="16" />
+              </Parameter>
+              <Parameter id="yYqabiwKIUGrSjSGk-OzQA" name="pKa_Acid_0" description="Smallest acid pKa" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TXUQXL-TBkiARr5yae4R3g" buildMode="Property" isDefault="1">
+                <Info min="0" max="14" flag="52" seq="1" ref="0" bb="2" group="16" />
+              </Parameter>
+              <Parameter id="C-I8kuQjVEKZ060M4MRt8Q" name="pKa_Acid_1" description="Middle acid pKa" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="qQdEhKKuq0OxvhZn_BRsvA" buildMode="Property" isDefault="1">
+                <Info min="0" max="14" flag="52" seq="1" ref="0" bb="2" group="16" />
+              </Parameter>
+              <Parameter id="cp-G-E95T0KErXSuPclDsw" name="pKa_Acid_2" description="Largest acid pKa" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="925QhXyEaEWMPVvNzOoYmg" buildMode="Property" isDefault="1">
+                <Info min="0" max="14" flag="52" seq="1" ref="0" bb="2" group="16" />
+              </Parameter>
+              <Parameter id="PcQPoXNZ2Uydzqb4-3RnJQ" name="pKa_Acids_Count" description="Number of acidic groups in compound" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="XuGn2ZPtwkOYmMV8vKBHSQ" buildMode="Property" isDefault="1">
+                <Info min="0" max="3" flag="52" seq="1" ref="0" bb="2" group="16" />
+              </Parameter>
+              <Parameter id="TNoYfHSabEueTOXZ88rJNw" name="pKa_Base_0" description="Smallest base pKa" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="kSdbPOqlQkSBX6Vcvi3pzA" buildMode="Property" isDefault="1">
+                <Info min="0" max="14" flag="52" seq="1" ref="0" bb="2" group="16" />
+              </Parameter>
+              <Parameter id="zN6Yh2OHKECgfDo_h02CdQ" name="pKa_Base_1" description="Middle base pKa" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="KJRbNDjHOk-Q4SMsVqwW1w" buildMode="Property" isDefault="1">
+                <Info min="0" max="14" flag="52" seq="1" ref="0" bb="2" group="16" />
+              </Parameter>
+              <Parameter id="M9dQ519_u0Ck7Avr1nAJ2Q" name="pKa_Base_2" description="Largest base pKa" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="HZLI71DS_ECjzZ9gejBHHQ" buildMode="Property" isDefault="1">
+                <Info min="0" max="14" flag="52" seq="1" ref="0" bb="2" group="16" />
+              </Parameter>
+              <Parameter id="IyDX2NdBOUmKwGJWQ0zjnQ" name="pKa_Bases_Count" description="Number of basic groups in compound" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Zj2fWiMTyUWd5C4IveAyvA" buildMode="Property" isDefault="1">
+                <Info min="0" max="3" flag="52" seq="1" ref="0" bb="2" group="16" />
+              </Parameter>
+              <Parameter id="h--gjCvUfEi2qvx-WkcT9Q" name="pKa_OneAcid_0" description="Smallest acid pKa for compound with 1 acid group" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="-xWRE492G0yP4ltbH8_FWA" buildMode="Property" isDefault="1">
+                <Info min="0" max="14" flag="52" seq="1" ref="0" bb="2" group="16" />
+              </Parameter>
+              <Parameter id="jDq29AmQEEmUgMLuUmvyTA" name="pKa_OneBase_0" description="Smallest base pKa for compound with 1 base group" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="wFOA6rTwDUKKUgDWGrmQ9A" buildMode="Property" isDefault="1">
+                <Info min="0" max="14" flag="52" seq="1" ref="0" bb="2" group="16" />
+              </Parameter>
+              <Parameter id="h-FHCBJd4U6-Y5KocnhoRA" name="pKa_pH_WS_sol_F1" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="4d4_CFrA8k658u44iOwF-A" buildMode="Property" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+              </Parameter>
+              <Parameter id="Ubqhsy_7ukWzhFKqgfMh0A" name="pKa_pH_WS_sol_F2" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="GP7bJMyV4EqBSmUMUpwFlg" buildMode="Property" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+              </Parameter>
+              <Parameter id="_suy8sd03UO5Cn-OdpfsQg" name="pKa_pH_WS_sol_F3" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TkeKaZP-t0qdwsta0SDj7w" buildMode="Property" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+              </Parameter>
+              <Parameter id="MtyysC2KxUmifhLujkvv8A" name="pKa_pH_WS_sol_K1" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="kghHnsDg1kaMIRV6LnINtA" buildMode="Property" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+              </Parameter>
+              <Parameter id="BY865GEcE0G6ZE38JnivBA" name="pKa_pH_WS_sol_K2" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="-wZjfwKUgECwz3w56xp3RA" buildMode="Property" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+              </Parameter>
+              <Parameter id="nlCh7C5THU6eTaUqY9ooXw" name="pKa_pH_WS_sol_K3" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="okilccp8REuGb_vyyPnurQ" buildMode="Property" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+              </Parameter>
+              <Parameter id="RSclla0Qr0yud5KY3TA_ug" name="pKa_pH_WS_sol_K4" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="tU5Zl8rJz0W2cgyxfVJXzQ" buildMode="Property" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+              </Parameter>
+              <Parameter id="ouWfsygZjU-rlj6NK3UVSA" name="pKa_pH_WS_sol_K5" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="hZ2-vsXClUeiTaqrJrz_Xg" buildMode="Property" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+              </Parameter>
+              <Parameter id="DTMOVWVBY0y6-RfDa11fyg" name="pKa_pH_WS_sol_K6" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="xHzg9Wk-MkaIxAU2KE3pIg" buildMode="Property" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+              </Parameter>
+              <Parameter id="dixM3ITFl0CbWz_4B0gi8Q" name="pKa_pH_WS_sol_K7" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="I0arg8PMok-TjRLexVSavg" buildMode="Property" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+              </Parameter>
+              <Parameter id="5Nm2LlLXy063DPKOMa0bFw" name="pKa_pH_WS_sol_K8" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ZZ5cNtFtz0GhAtrugDZ7bQ" buildMode="Property" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+              </Parameter>
+              <Parameter id="XbQOXJl5eUycnFpT0CeoxQ" name="pKa_ThreeAcids_0" description="Smallest acid pKa for compound with 3 acid groups" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="hF8MxdoU8EKrbKuyLMVszw" buildMode="Property" isDefault="1">
+                <Info min="0" max="14" flag="52" seq="1" ref="0" bb="2" group="16" />
+              </Parameter>
+              <Parameter id="58zSYKSRTESrk7ni5tX81g" name="pKa_ThreeAcids_1" description="Middle acid pKa for compound with 3 acid groups" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TqBUd1e5bki6S_mjXnIvMQ" buildMode="Property" isDefault="1">
+                <Info min="0" max="14" flag="52" seq="1" ref="0" bb="2" group="16" />
+              </Parameter>
+              <Parameter id="RAbg1Lqll0iSxb-Otl6JoA" name="pKa_ThreeBases_0" description="Smallest base pKa for compound with 3 base groups" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="7m9JECpQiUmn9AUvHKX1UA" buildMode="Property" isDefault="1">
+                <Info min="0" max="14" flag="52" seq="1" ref="0" bb="2" group="16" />
+              </Parameter>
+              <Parameter id="PWtDOqKF9U60zAtQ-Zq6GA" name="pKa_ThreeBases_1" description="Middle base pKa for compound with 3 base groups" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ZXPgGMB0ZEmcGESBHuh0mQ" buildMode="Property" isDefault="1">
+                <Info min="0" max="14" flag="52" seq="1" ref="0" bb="2" group="16" />
+              </Parameter>
+              <Parameter id="BdIb8DSfAki38gobZG4duA" name="pKa_TwoAcids_0" description="Smallest acid pKa for compound with 2 acid groups" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="MM14AMX_aUicLCPROtdHyQ" buildMode="Property" isDefault="1">
+                <Info min="0" max="14" flag="52" seq="1" ref="0" bb="2" group="16" />
+              </Parameter>
+              <Parameter id="j_1jsbf94EyMNhFl9lcZUg" name="pKa_TwoAcids_1" description="Middle acid pKa for compound with 2 acid groups" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="s4kDbBFMO0OOaDJ8MZBKOA" buildMode="Property" isDefault="1">
+                <Info min="0" max="14" flag="52" seq="1" ref="0" bb="2" group="16" />
+              </Parameter>
+              <Parameter id="ysiZt_QDN0K6Q1M_pETqKQ" name="pKa_TwoBases_0" description="Smallest base pKa for compound with 2 base groups" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="xpqP3k9f3k-6AjhJk-Qf1Q" buildMode="Property" isDefault="1">
+                <Info min="0" max="14" flag="52" seq="1" ref="0" bb="2" group="16" />
+              </Parameter>
+              <Parameter id="lKjsEYTojkCcwRI1s_Wnmw" name="pKa_TwoBases_1" description="Middle base pKa for compound with 2 base groups" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="qINVkL2LiUqFCWI2l3gwcA" buildMode="Property" isDefault="1">
+                <Info min="0" max="14" flag="52" seq="1" ref="0" bb="2" group="16" />
+              </Parameter>
+              <Parameter id="x1cp6mFvpkis6wskkGK4Jg" name="Plasma protein binding partner" description="Plasma protein to which the drug is predominantly bound. The ontogeny of the two most important plasma protein binding partners, albumin and α1-acid glycoprotein (AGP) is available in the PK-Sim database so that the fraction unbound in plasma can be scaled to children using the ontogeny of the respective protein. If  the binding partner is neither albumin nor AGP  or if scaling to children is not of interest, the third alternative (unknown) can be used. Please note that any other ontogeny can be uploaded for the scaling to children using the Population Simulation Toolbox in MoBi" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="1">
+                <Info flag="50" seq="1" ref="0" bb="2" group="9" />
+              </Parameter>
+              <Parameter id="Yz9AwtfJbEGWq4ALfG29ZA" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="wgJprPADyUKU8ir_bSOrJA" buildMode="Property" isDefault="1">
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="18" />
+              </Parameter>
+              <Parameter id="pFul8ZqVbUC1B490Qogw_w" name="Total drug mass" description="Total drug mass" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" formula="VD3F_ppSVkiiAkqZJh4jXw" buildMode="Property" isDefault="1" displayUnit="µmol">
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="9" />
+              </Parameter>
+              <Parameter id="dILyEmMkSkGJz-DCaKcqAg" name="Total oral drug mass" description="Total oral drug mass" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0" displayUnit="µmol">
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="63" />
+              </Parameter>
+              <Parameter id="SjyMS7ptH0yPEZXe9AtQ5g" name="Lipophilicity" description="Model dependent lipophilicity measure: LogMA / LogP / ..." icon="Parameter" persistable="0" isFixedValue="0" dim="Log Units" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="NaN" displayUnit="Log Units">
+                <Info min="-10" max="10" flag="50" seq="2" ref="0" bb="2" group="12" />
+              </Parameter>
+              <Parameter id="_sdGpKU89k685GJGp9eTow" name="Fraction unbound (plasma, reference value)" description="Fraction unbound in plasma of the reference individual, i.e. in the case of human typically an average healthy adult. This reference value can be scaled to children based on the ontogeny of the respective plasma protein and/or in diseased subjects using the plasma protein scale factor defined in the individual" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="NaN">
+                <Info min="0" max="1" flag="34" seq="3" ref="0" bb="2" group="10" />
+              </Parameter>
+              <Parameter id="8kG2ZO-vPEC9xc3x3ReiCA" name="Solubility at reference pH" description="Solubility at reference pH" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="NaN" displayUnit="mg/l">
+                <Info min="0" flag="50" seq="4" ref="0" bb="2" group="18" />
+              </Parameter>
+              <Parameter id="Nqo_H4hIDEyv3IMWpQORTw" name="Solubility table" description="Solubility table" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0" displayUnit="mg/l">
+                <Info min="0" flag="48" seq="4" ref="0" bb="2" group="18" />
+              </Parameter>
+              <Parameter id="FxhQrf5D2E67SGN70sQrGg" name="Reference pH" description="Reference pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="7">
+                <Info min="0" max="14" flag="50" seq="5" ref="0" bb="2" group="18" />
+              </Parameter>
+              <Parameter id="xg7nqBDQw0-HZgAAD7XqBA" name="Solubility gain per charge" description="Supporting parameter for calculation of pKa- and pH- dependent values of intestinal solubilty" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="1000">
+                <Info min="0" flag="34" seq="6" ref="0" bb="2" group="18" />
+              </Parameter>
+              <Parameter id="LQNm-4KOd0G6vu--Jbs0Xg" name="Permeability" description="Permeability" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="9EODsFHezUS7W8ZNAmEl4Q" buildMode="Property" isDefault="1" displayUnit="cm/min">
+                <Info min="0" flag="50" seq="7" ref="0" bb="2" group="15" />
+              </Parameter>
+              <Parameter id="j5-kBkpfZk6oCgkhSGH40g" name="Specific intestinal permeability (transcellular)" description="Specific intestinal permeability (transcellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="g2Hl-6SB90uX7RRzAnZRew" buildMode="Property" isDefault="1" displayUnit="cm/min">
+                <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
+                <Info min="0" flag="50" seq="8" ref="0" bb="2" group="11" />
+              </Parameter>
+              <Parameter id="GT68WR2J3kitNGZw4geRRA" name="Partition coefficient (water/protein)" description="Partition coefficient water to protein" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_pOSSZisV0eWF2zyM-B-0Q" buildMode="Global" isDefault="1">
+                <Info min="0" flag="50" seq="9" ref="0" bb="2" group="67" />
+              </Parameter>
+              <Parameter id="yvoeT8PfkkqPuPIVrUJ_YA" name="Treat precipitated drug as" description="Treat precipitated drug as either soluble or insoluble" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="1">
+                <Info min="0" max="1" flag="50" seq="30" ref="0" bb="2" group="14" />
+              </Parameter>
+              <Parameter id="Tlt2KkEc1kiNS_R1uwsCtQ" name="Aqueous diffusion coefficient" description="Aqueous diffusion coefficient&#xA;of the drug" icon="Parameter" persistable="0" isFixedValue="0" dim="Diffusion coefficient" quantityType="Parameter" negativeValuesAllowed="1" formula="mUeJp5uqsU2jDvOsAfTIaw" buildMode="Property" isDefault="1" displayUnit="cm²/min">
+                <ValueOrigin id="32" source="Publication" description="Willmann S, Thelen K, Becker C, et al. Mechanism-based prediction of particle size-dependent dissolution and absorption: cilostazol pharmacokinetics in dogs. Eur J Pharm Biopharm. 2010 Sep;76(1):83-94 https://doi.org/10.1016/j.ejpb.2010.06.003" />
+                <Info min="6E-13" max="0.6" flag="50" seq="31" ref="0" bb="2" group="14" />
+              </Parameter>
+              <Parameter id="Vv5W-DwL20eKrbGiUJBEIQ" name="Density (drug)" description="Density of drug material" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="1" displayUnit="g/cm³">
+                <ValueOrigin id="32" source="Publication" description="Willmann S, Thelen K, Becker C, et al. Mechanism-based prediction of particle size-dependent dissolution and absorption: cilostazol pharmacokinetics in dogs. Eur J Pharm Biopharm. 2010 Sep;76(1):83-94 https://doi.org/10.1016/j.ejpb.2010.06.003" />
+                <Info min="2.5E-06" flag="50" seq="32" ref="0" bb="2" group="14" />
+              </Parameter>
+              <Parameter id="eeQyKNgaMkeiGhuWo4wqjQ" name="Immediately dissolve particles smaller than" description="Threshold for the particle radius of immediate dissolution" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="1E-07" displayUnit="µm">
+                <ValueOrigin id="32" source="Publication" description="Willmann S, Thelen K, Becker C, et al. Mechanism-based prediction of particle size-dependent dissolution and absorption: cilostazol pharmacokinetics in dogs. Eur J Pharm Biopharm. 2010 Sep;76(1):83-94 https://doi.org/10.1016/j.ejpb.2010.06.003" />
+                <Info min="1E-35" flag="50" seq="33" ref="0" bb="2" group="14" />
+              </Parameter>
+              <Parameter id="XrrQuIaa40OnNDou1fCDKw" name="Radius (solute)" description="Solute radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="nQU37iN6-EiyuHr1KQQUUA" buildMode="Property" isDefault="1" displayUnit="µm">
+                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                <Info min="0" flag="50" seq="40" ref="0" bb="2" group="19" />
+              </Parameter>
+              <Parameter id="plGfgaildUOzcYdpoO5G7g" name="Kd (FcRn) in endosomal space" description="Dissociation constant of drug for binding to FcRn in endosomal space" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="999999" displayUnit="µmol/l">
+                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                <Info min="0" flag="50" seq="41" ref="0" bb="2" group="19" />
+              </Parameter>
+              <Parameter id="9ZrEQD_B9UCrAzn7hS6nMQ" name="Kd (FcRn) in plasma/interstitial" description="Dissociation constant of drug for binding to FcRn in plasma/interstitial space. For monoclonal antibodies the binding to FcRn in neutral environment (plasma and interstitial space) is generally very weak or not detectable. In this case the high default value for Kd(FcRn) in plasma/interstitial can be kept." icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="999999" displayUnit="µmol/l">
+                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                <Info min="0" flag="50" seq="42" ref="0" bb="2" group="19" />
+              </Parameter>
+              <Parameter id="waYQS0TPq0OTw4eogCF8Tw" name="kass (FcRn)" description="Association constant of drug for binding to FcRn" icon="Parameter" persistable="0" isFixedValue="0" dim="Second order rate constant" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0.87" displayUnit="l/µmol/min">
+                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                <Info min="0" flag="50" seq="43" ref="0" bb="2" group="19" />
+              </Parameter>
+              <Parameter id="y0BM2gxCCE2vEc2QHUctqg" name="Use pH- and pKa-dependent penalty factor for charged molecule fraction" description="Penalty factor for charged molecule fraction is used for &quot;Intestinal permeability (transcellular)&quot; only" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Global" isDefault="1" value="0">
+                <Info min="0" max="1" flag="50" seq="100" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="T6MiFPCdZkOAhLa8ZMAX8w" name="Enable supersaturation" description="Enabling supersaturation inactivates the limit of how much solute can be dissolved. It should always and only be allowed in combination with particle dissolution formulations; otherwise disabled. Enabling in case of other formulations results in a lack of the solubility limit and hence in infinitely soluble solutes." icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0">
+                <Info min="0" max="1" flag="50" seq="100" ref="0" bb="2" group="14" />
+              </Parameter>
+              <Parameter id="F5D2Iv0Y70C9ML5qvFVzjw" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="P1ACq2dGnUu9TLLm_inTQQ" isDefault="1" displayUnit="µmol/l">
+                <Info min="0" flag="18" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
+            </Children>
+          </MoleculeBuilder>
+          <MoleculeBuilder id="loMnyAWI_EeMM8ApWRyz-A" name="Aciclovir" icon="DRUG" mode="Logical" containerType="Other" isFloating="1" quantityType="Drug" isXenobiotic="1" dim="Amount" defaultStartFormula="fORVLtI2Akm8cWkdhbnPcw" displayUnit="µmol">
+            <Children>
+              <Parameter id="Ib1H1aNuO0mjDDWnPDI1Fg" name="base_For_KaPL_Factor" description="Supporting parameter for calculation of pKa- and pH- dependent values of KaPL" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="20">
+                <ValueOrigin id="34" source="Publication" description="Toxicol In Vitro. 2008 Mar;22(2):457-67 https://doi.org/10.1016/j.tiv.2007.09.010" />
+                <Info min="0" flag="36" seq="1" ref="0" bb="4" group="16" />
+              </Parameter>
+              <Parameter id="hf0OX_ZUQEO-GN4SbLLEtQ" name="base_For_logD_Factor" description="Supporting parameter for calculation of pKa- and pH- dependent logD" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0.001">
+                <ValueOrigin id="34" source="Publication" description="Toxicol In Vitro. 2008 Mar;22(2):457-67 https://doi.org/10.1016/j.tiv.2007.09.010" />
+                <Info min="0" flag="36" seq="1" ref="0" bb="4" group="16" />
+              </Parameter>
+              <Parameter id="B-WSp-5S0UyFdP-ZX9xS0w" name="base_For_P_cell_Factor" description="Supporting parameter for calculation of pKa- and pH- dependent permeability to/from cells" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0.001">
+                <Info min="0" flag="36" seq="1" ref="0" bb="4" group="16" />
+              </Parameter>
+              <Parameter id="iB0F-J0ytE22nMKxvob-Jw" name="base_For_Pint_Factor" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0.1">
+                <Info min="0" flag="36" seq="1" ref="0" bb="4" group="16" />
+              </Parameter>
+              <Parameter id="pkBgvA3hQkCSw15bhieGBA" name="BP_AGP" description="Constant for binding partner α1-acid glycoprotein" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0">
+                <Info flag="52" seq="1" ref="0" bb="4" group="9" />
+              </Parameter>
+              <Parameter id="jSzeZkU82k-E_VAIte7kIg" name="BP_ALBUMIN" description="Constant for binding partner albumin" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="1">
+                <Info flag="52" seq="1" ref="0" bb="4" group="9" />
+              </Parameter>
+              <Parameter id="8MQ6iKZirEe5GzXqQLN_fQ" name="BP_UNKNOWN" description="Constant for binding partner unknown" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="2">
+                <Info flag="52" seq="1" ref="0" bb="4" group="9" />
+              </Parameter>
+              <Parameter id="Uqw3tYSHdEWO8_Db08a-uA" name="Br" description="Number of bromine atoms in molecule" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0">
+                <Info min="0" max="10" flag="58" seq="1" ref="0" bb="4" group="13" />
+              </Parameter>
+              <Parameter id="43k7hhtafkuaPW4kJqKBxg" name="Calculated specific intestinal permeability (transcellular)" description="Calculated specific intestinal permeability (transcellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="g2Hl-6SB90uX7RRzAnZRew" buildMode="Global" isDefault="1" displayUnit="cm/min">
+                <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="V7tbkm5uYE2tTkhUihLn6A" name="Cl" description="Number of chlorine atoms in molecule" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0">
+                <Info min="0" max="10" flag="58" seq="1" ref="0" bb="4" group="13" />
+              </Parameter>
+              <Parameter id="8i0t1_wJy0aYGxwTfEWWsw" name="Compound type 0" description="Compound type (-1: acid, +1: base, 0: neutral)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="-1">
+                <Info min="-1" max="1" flag="58" seq="1" ref="0" bb="4" group="16" />
+              </Parameter>
+              <Parameter id="RV8W1NIjtEC3UqYBZMQxGw" name="Compound type 1" description="Compound type (-1: acid, +1: base, 0: neutral)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="1">
+                <Info min="-1" max="1" flag="58" seq="1" ref="0" bb="4" group="16" />
+              </Parameter>
+              <Parameter id="e-OYWYUwVk6UWL6p0_KbpQ" name="Compound type 2" description="Compound type (-1: acid, +1: base, 0: neutral)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0">
+                <Info min="-1" max="1" flag="58" seq="1" ref="0" bb="4" group="16" />
+              </Parameter>
+              <Parameter id="VlUX6Ud55kqIfks9eu2ctA" name="CT_ACID" description="Constant for compound type acid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="-1">
+                <Info min="-1" max="-1" flag="52" seq="1" ref="0" bb="4" group="16" />
+              </Parameter>
+              <Parameter id="shgLMBNIGES78L9Sb3DKXQ" name="CT_BASE" description="Constant for compound type base" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="1">
+                <Info min="1" max="1" flag="52" seq="1" ref="0" bb="4" group="16" />
+              </Parameter>
+              <Parameter id="PKQf0cPCC0auPnsZZB0p3A" name="CT_NEUTRAL" description="Constant for compound type neutral" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0">
+                <Info min="0" max="0" flag="52" seq="1" ref="0" bb="4" group="16" />
+              </Parameter>
+              <Parameter id="LQWlakjNoEiZdlq7BAh8Yw" name="Effective molecular weight" description="Effective molecular weight" icon="Parameter" persistable="0" isFixedValue="0" dim="Molecular weight" quantityType="Parameter" negativeValuesAllowed="1" formula="bjrJlspJx0CVb0sqctCXhw" buildMode="Property" isDefault="1" displayUnit="g/mol">
+                <ValueOrigin id="25" source="Publication" description="Stefan Willmann, Walter Schmitt,Jörg Keldenich, Jörg Lippert, and Jennifer B. Dressman: A Physiological Model for the Estimation of the Fraction Dose Absorbed in Humans. J. Med. Chem. 2004, 47, 4022-4031" />
+                <Info min="1.5E-08" flag="62" seq="1" ref="0" bb="4" group="13" />
+              </Parameter>
+              <Parameter id="YSlD6pPkc0OtbvNFJ5Jp7w" name="F" description="Number of fluorine atoms in molecule" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0">
+                <Info min="0" max="10" flag="58" seq="1" ref="0" bb="4" group="13" />
+              </Parameter>
+              <Parameter id="9i2qbf7tq0ebssljKC34CQ" name="Has halogens" description="Supporting parameter for compound" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="eDrmMuaBIEWvXE2zKj6jCw" buildMode="Property" isDefault="1">
+                <Info min="0" flag="60" seq="1" ref="0" bb="4" group="13" />
+              </Parameter>
+              <Parameter id="djoMuxSyOUOVqYrkhwYcBg" name="I" description="Number of iodine atoms in molecule" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0">
+                <Info min="0" max="10" flag="58" seq="1" ref="0" bb="4" group="13" />
+              </Parameter>
+              <Parameter id="2mzMXqaa8Uifue6x7jifPQ" name="Is diprotic acid" description="Is diprotic acid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="O0Ygj5BtsUmaMSiCQ2BA2w" buildMode="Property" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="4" group="16" />
+              </Parameter>
+              <Parameter id="p9if1FfLP0Cw-QpTIqHtww" name="Is diprotic base" description="Is diprotic base" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="LBv9JCs2O0-e4Rea2Qhb2A" buildMode="Property" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="4" group="16" />
+              </Parameter>
+              <Parameter id="8vf9GdwyP0m-yWBFYBlA2Q" name="Is diprotic base monoprotic acid" description="Is diprotic base monoprotic acid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IOi-kI6sskuhyfzxHybZ_A" buildMode="Property" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="4" group="16" />
+              </Parameter>
+              <Parameter id="6iO48NJkRkWDIb82zWYSGQ" name="Is floating in lumen" description="Is floating in lumen" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="4" group="9" />
+              </Parameter>
+              <Parameter id="WpmUlYz110-veYXWCpz9Gw" name="Is monoprotic acid" description="Is monoprotic acid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="1NjeU1paL0Wl3efDoSLREw" buildMode="Property" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="4" group="16" />
+              </Parameter>
+              <Parameter id="rCFoSSiWjUObWTqUHREreA" name="Is monoprotic base" description="Is monoprotic base" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Ezm2VQdJT06z4p1RJr89Xg" buildMode="Property" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="4" group="16" />
+              </Parameter>
+              <Parameter id="ZRwlLzu8uky18u0vGLT9sw" name="Is monoprotic base diprotic acid" description="Is monoprotic base diprotic acid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CwKTESVg_0OHyq4gXSiKLA" buildMode="Property" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="4" group="16" />
+              </Parameter>
+              <Parameter id="Bm1KEt_0OkCDm0KYDJV60Q" name="Is monoprotic base monoprotic acid" description="Is monoprotic base monoprotic acid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="NnE3JQPE1UuvApxiOd8wEw" buildMode="Property" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="4" group="16" />
+              </Parameter>
+              <Parameter id="BYJjW4HBeEe06scbKGrr2Q" name="Is neutral" description="Supporting parameter for partition coeffs in RR-Modell" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="0UdLvHK2PU2xFuUkIbBCGw" buildMode="Property" isDefault="1">
+                <Info min="0" flag="52" seq="1" ref="0" bb="4" group="16" />
+              </Parameter>
+              <Parameter id="7Wy_xw_npkWD6sH1Gbib8g" name="Is small molecule" description="Treat compound as small molecule or not (if not, both organ specific and intestinal permeability will be set to zero)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="0" value="1">
+                <Info min="0" max="1" flag="60" seq="1" ref="0" bb="4" group="9" />
+              </Parameter>
+              <Parameter id="3izTbxECHkqjhB1OEyo8xg" name="Is strong base" description="Supporting parameter for partition coeffs in RR-Modell (at least one basic pKa&gt;=7)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CbDAqBiHk0aGzu-AaQOI_g" buildMode="Property" isDefault="1">
+                <Info min="0" flag="52" seq="1" ref="0" bb="4" group="16" />
+              </Parameter>
+              <Parameter id="LU6qhiMRGUiCzkJcpS5NXg" name="Is triprotic acid" description="Is triprotic acid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="NfIRysJkWUu9n8E9oEfRjQ" buildMode="Property" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="4" group="16" />
+              </Parameter>
+              <Parameter id="BxyLZPy9BkaX6_CllTeRVQ" name="Is triprotic base" description="Is triprotic base" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="tH4SauLaaE2EhlcuiRWwCQ" buildMode="Property" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="4" group="16" />
+              </Parameter>
+              <Parameter id="CUroT-bo8U2b-JjNx7QQ8A" name="Molecular weight" description="Molecular weight" icon="Parameter" persistable="0" isFixedValue="0" dim="Molecular weight" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="0" value="2.2521E-07" displayUnit="g/mol">
+                <Info min="1.5E-08" flag="56" seq="1" ref="0" bb="4" group="13" />
+              </Parameter>
+              <Parameter id="OHUwg_v_R0O9aNjVKF3_WQ" name="pKa value 0" description="pKa value" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="9.2">
+                <Info min="0" max="14" flag="58" seq="1" ref="0" bb="4" group="16" />
+              </Parameter>
+              <Parameter id="GuRSPDu-EESxw4Kul81MZQ" name="pKa value 1" description="pKa value" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="2.2">
+                <Info min="0" max="14" flag="58" seq="1" ref="0" bb="4" group="16" />
+              </Parameter>
+              <Parameter id="GkeTwrADyUKL6mgbIYVaKw" name="pKa value 2" description="pKa value" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0">
+                <Info min="0" max="14" flag="58" seq="1" ref="0" bb="4" group="16" />
+              </Parameter>
+              <Parameter id="hDQvFMwCpkOD4sOotQqvnQ" name="pKa_Acid_0" description="Smallest acid pKa" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TXUQXL-TBkiARr5yae4R3g" buildMode="Property" isDefault="1">
+                <Info min="0" max="14" flag="52" seq="1" ref="0" bb="4" group="16" />
+              </Parameter>
+              <Parameter id="lmo07EAbZ0ysHWxzSQUHgw" name="pKa_Acid_1" description="Middle acid pKa" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="qQdEhKKuq0OxvhZn_BRsvA" buildMode="Property" isDefault="1">
+                <Info min="0" max="14" flag="52" seq="1" ref="0" bb="4" group="16" />
+              </Parameter>
+              <Parameter id="7EvUJcb0fUa_IAOrXi4zCg" name="pKa_Acid_2" description="Largest acid pKa" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="925QhXyEaEWMPVvNzOoYmg" buildMode="Property" isDefault="1">
+                <Info min="0" max="14" flag="52" seq="1" ref="0" bb="4" group="16" />
+              </Parameter>
+              <Parameter id="N5XYuLj5UE66FzrBg9Mw7g" name="pKa_Acids_Count" description="Number of acidic groups in compound" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="XuGn2ZPtwkOYmMV8vKBHSQ" buildMode="Property" isDefault="1">
+                <Info min="0" max="3" flag="52" seq="1" ref="0" bb="4" group="16" />
+              </Parameter>
+              <Parameter id="e8n9EVXAw0a4xE6kw_VPPw" name="pKa_Base_0" description="Smallest base pKa" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="kSdbPOqlQkSBX6Vcvi3pzA" buildMode="Property" isDefault="1">
+                <Info min="0" max="14" flag="52" seq="1" ref="0" bb="4" group="16" />
+              </Parameter>
+              <Parameter id="RrZAW83xdkSlRYQPyfJGLA" name="pKa_Base_1" description="Middle base pKa" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="KJRbNDjHOk-Q4SMsVqwW1w" buildMode="Property" isDefault="1">
+                <Info min="0" max="14" flag="52" seq="1" ref="0" bb="4" group="16" />
+              </Parameter>
+              <Parameter id="JdCBC2evREuTD6YBJvTz2g" name="pKa_Base_2" description="Largest base pKa" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="HZLI71DS_ECjzZ9gejBHHQ" buildMode="Property" isDefault="1">
+                <Info min="0" max="14" flag="52" seq="1" ref="0" bb="4" group="16" />
+              </Parameter>
+              <Parameter id="FObijGFZVEOP0w9zP_QMnw" name="pKa_Bases_Count" description="Number of basic groups in compound" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Zj2fWiMTyUWd5C4IveAyvA" buildMode="Property" isDefault="1">
+                <Info min="0" max="3" flag="52" seq="1" ref="0" bb="4" group="16" />
+              </Parameter>
+              <Parameter id="aps90k7Dkk2lUe91CXHBdg" name="pKa_OneAcid_0" description="Smallest acid pKa for compound with 1 acid group" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="-xWRE492G0yP4ltbH8_FWA" buildMode="Property" isDefault="1">
+                <Info min="0" max="14" flag="52" seq="1" ref="0" bb="4" group="16" />
+              </Parameter>
+              <Parameter id="sE10qOUFRkOx3uJX9G1-Gw" name="pKa_OneBase_0" description="Smallest base pKa for compound with 1 base group" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="wFOA6rTwDUKKUgDWGrmQ9A" buildMode="Property" isDefault="1">
+                <Info min="0" max="14" flag="52" seq="1" ref="0" bb="4" group="16" />
+              </Parameter>
+              <Parameter id="uhBvhl09a0CG0wrv4bZxlw" name="pKa_pH_WS_sol_F1" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="4d4_CFrA8k658u44iOwF-A" buildMode="Property" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="4" group="18" />
+              </Parameter>
+              <Parameter id="Rat0a1cr40WmeGXj5C3xHA" name="pKa_pH_WS_sol_F2" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="GP7bJMyV4EqBSmUMUpwFlg" buildMode="Property" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="4" group="18" />
+              </Parameter>
+              <Parameter id="PFTnxT6aWk-AroeHXoKI8g" name="pKa_pH_WS_sol_F3" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TkeKaZP-t0qdwsta0SDj7w" buildMode="Property" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="4" group="18" />
+              </Parameter>
+              <Parameter id="bUaN_9hUl0qZ3BGWAADiDA" name="pKa_pH_WS_sol_K1" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="kghHnsDg1kaMIRV6LnINtA" buildMode="Property" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="4" group="18" />
+              </Parameter>
+              <Parameter id="htgLC2B6DUiksdYAMaZhZA" name="pKa_pH_WS_sol_K2" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="-wZjfwKUgECwz3w56xp3RA" buildMode="Property" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="4" group="18" />
+              </Parameter>
+              <Parameter id="-lPjWJSyu0mJ9N8v2TJjNw" name="pKa_pH_WS_sol_K3" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="okilccp8REuGb_vyyPnurQ" buildMode="Property" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="4" group="18" />
+              </Parameter>
+              <Parameter id="aaeEMaApCEmjl6BMlQRCTw" name="pKa_pH_WS_sol_K4" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="tU5Zl8rJz0W2cgyxfVJXzQ" buildMode="Property" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="4" group="18" />
+              </Parameter>
+              <Parameter id="CGyjGMwzKkmDmZUs8GvyXg" name="pKa_pH_WS_sol_K5" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="hZ2-vsXClUeiTaqrJrz_Xg" buildMode="Property" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="4" group="18" />
+              </Parameter>
+              <Parameter id="758S-FQvB0GML6SOXZKcvQ" name="pKa_pH_WS_sol_K6" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="xHzg9Wk-MkaIxAU2KE3pIg" buildMode="Property" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="4" group="18" />
+              </Parameter>
+              <Parameter id="B1KyMmikIEeSDF6DdpsFoQ" name="pKa_pH_WS_sol_K7" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="I0arg8PMok-TjRLexVSavg" buildMode="Property" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="4" group="18" />
+              </Parameter>
+              <Parameter id="954f-luZLEi2TWWAN4ye4g" name="pKa_pH_WS_sol_K8" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ZZ5cNtFtz0GhAtrugDZ7bQ" buildMode="Property" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="4" group="18" />
+              </Parameter>
+              <Parameter id="cAC2K5eIC0a_GGEPODtlgg" name="pKa_ThreeAcids_0" description="Smallest acid pKa for compound with 3 acid groups" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="hF8MxdoU8EKrbKuyLMVszw" buildMode="Property" isDefault="1">
+                <Info min="0" max="14" flag="52" seq="1" ref="0" bb="4" group="16" />
+              </Parameter>
+              <Parameter id="-fuhVb15HEGdrhvJ2QNKMw" name="pKa_ThreeAcids_1" description="Middle acid pKa for compound with 3 acid groups" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TqBUd1e5bki6S_mjXnIvMQ" buildMode="Property" isDefault="1">
+                <Info min="0" max="14" flag="52" seq="1" ref="0" bb="4" group="16" />
+              </Parameter>
+              <Parameter id="E5rezb-VuU2IZ_L__wm6CQ" name="pKa_ThreeBases_0" description="Smallest base pKa for compound with 3 base groups" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="7m9JECpQiUmn9AUvHKX1UA" buildMode="Property" isDefault="1">
+                <Info min="0" max="14" flag="52" seq="1" ref="0" bb="4" group="16" />
+              </Parameter>
+              <Parameter id="CEVMjktENECjCKN9_PE44g" name="pKa_ThreeBases_1" description="Middle base pKa for compound with 3 base groups" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ZXPgGMB0ZEmcGESBHuh0mQ" buildMode="Property" isDefault="1">
+                <Info min="0" max="14" flag="52" seq="1" ref="0" bb="4" group="16" />
+              </Parameter>
+              <Parameter id="sVKsGnMAjU6b5igyZxpUGA" name="pKa_TwoAcids_0" description="Smallest acid pKa for compound with 2 acid groups" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="MM14AMX_aUicLCPROtdHyQ" buildMode="Property" isDefault="1">
+                <Info min="0" max="14" flag="52" seq="1" ref="0" bb="4" group="16" />
+              </Parameter>
+              <Parameter id="4VfnkWRs_UqROCoHLsl0Pg" name="pKa_TwoAcids_1" description="Middle acid pKa for compound with 2 acid groups" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="s4kDbBFMO0OOaDJ8MZBKOA" buildMode="Property" isDefault="1">
+                <Info min="0" max="14" flag="52" seq="1" ref="0" bb="4" group="16" />
+              </Parameter>
+              <Parameter id="mM7KmUR1EUyFZm38_DVO6A" name="pKa_TwoBases_0" description="Smallest base pKa for compound with 2 base groups" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="xpqP3k9f3k-6AjhJk-Qf1Q" buildMode="Property" isDefault="1">
+                <Info min="0" max="14" flag="52" seq="1" ref="0" bb="4" group="16" />
+              </Parameter>
+              <Parameter id="FFGcvs1BJkK5LqOQHBjP4w" name="pKa_TwoBases_1" description="Middle base pKa for compound with 2 base groups" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="qINVkL2LiUqFCWI2l3gwcA" buildMode="Property" isDefault="1">
+                <Info min="0" max="14" flag="52" seq="1" ref="0" bb="4" group="16" />
+              </Parameter>
+              <Parameter id="0GHRHoqJp0GWm2UCTHL5uw" name="Plasma protein binding partner" description="Plasma protein to which the drug is predominantly bound. The ontogeny of the two most important plasma protein binding partners, albumin and α1-acid glycoprotein (AGP) is available in the PK-Sim database so that the fraction unbound in plasma can be scaled to children using the ontogeny of the respective protein. If  the binding partner is neither albumin nor AGP  or if scaling to children is not of interest, the third alternative (unknown) can be used. Please note that any other ontogeny can be uploaded for the scaling to children using the Population Simulation Toolbox in MoBi" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="0" value="1">
+                <Info flag="58" seq="1" ref="0" bb="4" group="9" />
+              </Parameter>
+              <Parameter id="UlD_OK10LEWmsMZebtqQkQ" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="wgJprPADyUKU8ir_bSOrJA" buildMode="Property" isDefault="1">
+                <Info min="0" flag="52" seq="1" ref="0" bb="4" group="18" />
+              </Parameter>
+              <Parameter id="OULoZIiDX0Gh27ycWcywpA" name="Total drug mass" description="Total drug mass" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" formula="VD3F_ppSVkiiAkqZJh4jXw" buildMode="Property" isDefault="1" displayUnit="µmol">
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="9" />
+              </Parameter>
+              <Parameter id="ERBm1oDkBEur2i2eqUzlWw" name="Total oral drug mass" description="Total oral drug mass" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0" displayUnit="µmol">
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="63" />
+              </Parameter>
+              <Parameter id="8NkRi0Rlw0ejunLZTmHAPQ" name="Lipophilicity" description="Model dependent lipophilicity measure: LogMA / LogP / ..." icon="Parameter" persistable="0" isFixedValue="0" dim="Log Units" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="0" value="-0.097" displayUnit="Log Units">
+                <Info min="-10" max="10" flag="58" seq="2" ref="0" bb="4" group="12" />
+              </Parameter>
+              <Parameter id="j8BnMWbSqk6E6pkvd1B7hQ" name="Fraction unbound (plasma, reference value)" description="Fraction unbound in plasma of the reference individual, i.e. in the case of human typically an average healthy adult. This reference value can be scaled to children based on the ontogeny of the respective plasma protein and/or in diseased subjects using the plasma protein scale factor defined in the individual" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="0" value="0.85">
+                <Info min="0" max="1" flag="106" seq="3" ref="0" bb="4" group="10" />
+              </Parameter>
+              <Parameter id="XrHh35xEKE6lT7uCDIZpgA" name="Solubility at reference pH" description="Solubility at reference pH" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="0" value="0.03399" displayUnit="mg/l">
+                <Info min="0" flag="122" seq="4" ref="0" bb="4" group="18" />
+              </Parameter>
+              <Parameter id="ADsqV0T1Zk2QORtX-5do4Q" name="Solubility table" description="Solubility table" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0" displayUnit="mg/l">
+                <Info min="0" flag="48" seq="4" ref="0" bb="4" group="18" />
+              </Parameter>
+              <Parameter id="HdomRekW40a81l0-ZGX8xg" name="Reference pH" description="Reference pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="0" value="7">
+                <Info min="0" max="14" flag="58" seq="5" ref="0" bb="4" group="18" />
+              </Parameter>
+              <Parameter id="OCsTilPT7k2FP4vGQS5q0Q" name="Solubility gain per charge" description="Supporting parameter for calculation of pKa- and pH- dependent values of intestinal solubilty" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="1000">
+                <Info min="0" flag="42" seq="6" ref="0" bb="4" group="18" />
+              </Parameter>
+              <Parameter id="hej-sTe9ak61X3IE78Gn-w" name="Permeability" description="Permeability" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="9EODsFHezUS7W8ZNAmEl4Q" buildMode="Property" isDefault="1" displayUnit="cm/min">
+                <Info min="0" flag="62" seq="7" ref="0" bb="4" group="15" />
+              </Parameter>
+              <Parameter id="T2QzWWjv6EaaB-DUuy0bEQ" name="Specific intestinal permeability (transcellular)" description="Specific intestinal permeability (transcellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="g2Hl-6SB90uX7RRzAnZRew" buildMode="Property" isDefault="1" displayUnit="cm/min">
+                <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
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+              <Parameter id="mx32meGWsUG8RmUUqFQlig" name="Treat precipitated drug as" description="Treat precipitated drug as either soluble or insoluble" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="1">
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+              <Parameter id="IYEKtfzKJEyGCqsFOEtVlw" name="Aqueous diffusion coefficient" description="Aqueous diffusion coefficient&#xA;of the drug" icon="Parameter" persistable="0" isFixedValue="0" dim="Diffusion coefficient" quantityType="Parameter" negativeValuesAllowed="1" formula="mUeJp5uqsU2jDvOsAfTIaw" buildMode="Property" isDefault="1" displayUnit="cm²/min">
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+                <Info min="6E-13" max="0.6" flag="58" seq="31" ref="0" bb="4" group="14" />
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+              <Parameter id="Idhboiz_ukeVMBMxrhVdJg" name="Density (drug)" description="Density of drug material" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="1" displayUnit="g/cm³">
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+                <Info min="2.5E-06" flag="58" seq="32" ref="0" bb="4" group="14" />
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+              <Parameter id="j9FFIdrGpk-BKmhxHQvCAQ" name="Immediately dissolve particles smaller than" description="Threshold for the particle radius of immediate dissolution" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="1E-07" displayUnit="µm">
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+                <Info min="1E-35" flag="58" seq="33" ref="0" bb="4" group="14" />
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+              <UsedCalculationMethod category="IntestinalPermeability" calculationMethod="IntestinalPermeability_PKSim" />
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+              <Paths>
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+              <Paths>
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+              <Paths>
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+              <Paths>
+                <Path path="59" as="60" />
+                <Path path="43" as="44" />
+                <Path path="45" as="46" />
+                <Path path="47" as="48" />
+                <Path path="90" as="91" />
+                <Path path="92" as="93" />
+              </Paths>
+            </Formula>
+            <Formula id="7m9JECpQiUmn9AUvHKX1UA" name="PARAM_pKa_ThreeBases_0" formula="IsTriproticBase ? Min (pKa_0; Min (pKa_1; pKa_2)) : 0">
+              <Paths>
+                <Path path="76" as="77" />
+                <Path path="43" as="44" />
+                <Path path="45" as="46" />
+                <Path path="47" as="48" />
+              </Paths>
+            </Formula>
+            <Formula id="ZXPgGMB0ZEmcGESBHuh0mQ" name="PARAM_pKa_ThreeBases_1" formula="IsTriproticBase ? (pKa_0 &lt;= pKa_Base_0 ? min(pKa_1; pKa_2) : (pKa_0 &gt;= pKa_Base_2 ? max(pKa_1; pKa_2) : pKa_0)) : 0">
+              <Paths>
+                <Path path="76" as="77" />
+                <Path path="43" as="44" />
+                <Path path="45" as="46" />
+                <Path path="47" as="48" />
+                <Path path="94" as="95" />
+                <Path path="96" as="97" />
+              </Paths>
+            </Formula>
+            <Formula id="MM14AMX_aUicLCPROtdHyQ" name="PARAM_pKa_TwoAcids_0" formula="pKa_Acids_Count=2 ? (CT0 != CT_ACID ? Min(pKa_1;pKa_2) : (CT1 != CT_ACID ? Min(pKa_0;pKa_2) : Min(pKa_0;pKa_1))) : 0">
+              <Paths>
+                <Path path="61" as="62" />
+                <Path path="37" as="63" />
+                <Path path="39" as="64" />
+                <Path path="43" as="44" />
+                <Path path="45" as="46" />
+                <Path path="47" as="48" />
+                <Path path="33" as="34" />
+              </Paths>
+            </Formula>
+            <Formula id="s4kDbBFMO0OOaDJ8MZBKOA" name="PARAM_pKa_TwoAcids_1" formula="pKa_Acids_Count=2 ? (CT0 != CT_ACID ? Max(pKa_1;pKa_2) : (CT1 != CT_ACID ? Max(pKa_0;pKa_2) : Max(pKa_0;pKa_1))) : 0">
+              <Paths>
+                <Path path="61" as="62" />
+                <Path path="37" as="63" />
+                <Path path="39" as="64" />
+                <Path path="43" as="44" />
+                <Path path="45" as="46" />
+                <Path path="47" as="48" />
+                <Path path="33" as="34" />
+              </Paths>
+            </Formula>
+            <Formula id="xpqP3k9f3k-6AjhJk-Qf1Q" name="PARAM_pKa_TwoBases_0" formula="pKa_Bases_Count=2 ? (CT0 != CT_BASE ? Min(pKa_1;pKa_2) : (CT1 != CT_BASE ? Min(pKa_0;pKa_2) : Min(pKa_0;pKa_1))) : 0">
+              <Paths>
+                <Path path="78" as="79" />
+                <Path path="37" as="63" />
+                <Path path="39" as="64" />
+                <Path path="43" as="44" />
+                <Path path="45" as="46" />
+                <Path path="47" as="48" />
+                <Path path="35" as="36" />
+              </Paths>
+            </Formula>
+            <Formula id="qINVkL2LiUqFCWI2l3gwcA" name="PARAM_pKa_TwoBases_1" formula="pKa_Bases_Count=2 ? (CT0 != CT_BASE ? Max(pKa_1;pKa_2) : (CT1 != CT_BASE ? Max(pKa_0;pKa_2) : Max(pKa_0;pKa_1))) : 0">
+              <Paths>
+                <Path path="78" as="79" />
+                <Path path="37" as="63" />
+                <Path path="39" as="64" />
+                <Path path="43" as="44" />
+                <Path path="45" as="46" />
+                <Path path="47" as="48" />
+                <Path path="35" as="36" />
+              </Paths>
+            </Formula>
+            <Formula id="wgJprPADyUKU8ir_bSOrJA" name="PARAM_Solubility_pKa_RefpH_Factor" formula="K1+K2/base^(CT0^2)+K3/base^(CT1^2)+K4/base^(CT2^2)+K5/base^max(CT0+CT1;-CT0-CT1)+K6/base^max(CT0+CT2;-CT0-CT2)+K7/base^max(CT1+CT2;-CT1-CT2)+K8/base^max(CT0+CT1+CT2;-CT0-CT1-CT2)">
+              <Paths>
+                <Path path="37" as="63" />
+                <Path path="39" as="64" />
+                <Path path="41" as="65" />
+                <Path path="98" as="99" />
+                <Path path="100" as="101" />
+                <Path path="102" as="103" />
+                <Path path="104" as="105" />
+                <Path path="106" as="107" />
+                <Path path="108" as="109" />
+                <Path path="110" as="111" />
+                <Path path="112" as="113" />
+                <Path path="114" as="115" />
+              </Paths>
+            </Formula>
+            <SumFormula id="VD3F_ppSVkiiAkqZJh4jXw" name="PARAM_TotalDrugMass" dim="Amount" variable="P" formulaString="P_#i">
+              <Criteria>
+                <DescriptorConditions>
+                  <MatchTagCondition tag="DrugMass" />
+                  <MatchTagCondition tag="MOLECULE" />
+                </DescriptorConditions>
+              </Criteria>
+            </SumFormula>
+            <Formula id="9EODsFHezUS7W8ZNAmEl4Q" name="PARAM_P" dim="Velocity" formula="IsSmallMolecule ? (MWEff *1E9 / 336) ^ (-6) * 10^LogMA / 5 * 1E-4 *1E-1: 0">
+              <Paths>
+                <Path path="14" as="15" dim="16" />
+                <Path path="17" as="18" />
+                <Path path="19" as="20" dim="21" />
+              </Paths>
+            </Formula>
+            <Formula id="_pOSSZisV0eWF2zyM-B-0Q" name="PARAM_KProt" formula="(0.81 + 0.11 * 10^LogMA) / 24.92 * 5.0">
+              <Paths>
+                <Path path="19" as="20" dim="21" />
+              </Paths>
+            </Formula>
+            <Formula id="mUeJp5uqsU2jDvOsAfTIaw" name="PARAM_Aqueous_diffusion_coefficient" dim="Diffusion coefficient" formula="60 * 10^(-4.113-0.4609*Log10(MW * 1E9)) *1E-2">
+              <Paths>
+                <Path path="30" as="31" dim="16" />
+              </Paths>
+            </Formula>
+            <Formula id="nQU37iN6-EiyuHr1KQQUUA" name="PARAM_Ae" dim="Length" formula="0,0333 * (MW * 1E9) ^ 0,4226 * 1E-8">
+              <Paths>
+                <Path path="30" as="31" dim="16" />
+              </Paths>
+            </Formula>
+            <Formula id="9Bpm4mXN3kCeacGHBDElvA" name="STARTAMOUNT_Protein" dim="Amount" formula="M_0">
+              <Paths>
+                <Path path="116" as="117" dim="118" />
+              </Paths>
+            </Formula>
+            <Formula id="P1ACq2dGnUu9TLLm_inTQQ" name="ConcFormula" dim="Concentration (molar)" formula="V&gt;0 ? M/V : 0">
+              <Paths>
+                <Path path="119" as="120" dim="118" />
+                <Path path="121" as="122" dim="13" />
+              </Paths>
+            </Formula>
+            <ConstantFormula id="fORVLtI2Akm8cWkdhbnPcw" dim="Amount" value="0" />
+          </Formulas>
+          <StringMap>
+            <Map s="..|t1/2" id="0" />
+            <Map s="tHalf" id="1" />
+            <Map s="Time" id="2" />
+            <Map s="..|Ontogeny factor" id="3" />
+            <Map s="f_onto" id="4" />
+            <Map s="..|Relative expression out." id="5" />
+            <Map s="rel_exp_out" id="6" />
+            <Map s="Fraction" id="7" />
+            <Map s="MOLECULE|Reference concentration" id="8" />
+            <Map s="AF" id="9" />
+            <Map s="Concentration (molar)" id="10" />
+            <Map s="..|..|Volume of protein container" id="11" />
+            <Map s="ProteinContainerVolume" id="12" />
+            <Map s="Volume" id="13" />
+            <Map s="..|Effective molecular weight" id="14" />
+            <Map s="MWEff" id="15" />
+            <Map s="Molecular weight" id="16" />
+            <Map s="..|Is small molecule" id="17" />
+            <Map s="IsSmallMolecule" id="18" />
+            <Map s="..|Lipophilicity" id="19" />
+            <Map s="LogMA" id="20" />
+            <Map s="Log Units" id="21" />
+            <Map s="..|Br" id="22" />
+            <Map s="Br" id="23" />
+            <Map s="..|Cl" id="24" />
+            <Map s="Cl" id="25" />
+            <Map s="..|F" id="26" />
+            <Map s="F" id="27" />
+            <Map s="..|I" id="28" />
+            <Map s="I" id="29" />
+            <Map s="..|Molecular weight" id="30" />
+            <Map s="MW" id="31" />
+            <Map s="Chlor" id="32" />
+            <Map s="..|pKa_Acids_Count" id="33" />
+            <Map s="pKa_Acids_Count" id="34" />
+            <Map s="..|pKa_Bases_Count" id="35" />
+            <Map s="pKa_Bases_Count" id="36" />
+            <Map s="..|Compound type 0" id="37" />
+            <Map s="CT_0" id="38" />
+            <Map s="..|Compound type 1" id="39" />
+            <Map s="CT_1" id="40" />
+            <Map s="..|Compound type 2" id="41" />
+            <Map s="CT_2" id="42" />
+            <Map s="..|pKa value 0" id="43" />
+            <Map s="pKa_0" id="44" />
+            <Map s="..|pKa value 1" id="45" />
+            <Map s="pKa_1" id="46" />
+            <Map s="..|pKa value 2" id="47" />
+            <Map s="pKa_2" id="48" />
+            <Map s="..|pKa_OneAcid_0" id="49" />
+            <Map s="pKa_OneAcid_0" id="50" />
+            <Map s="..|pKa_ThreeAcids_0" id="51" />
+            <Map s="pKa_ThreeAcids_0" id="52" />
+            <Map s="..|pKa_TwoAcids_0" id="53" />
+            <Map s="pKa_TwoAcids_0" id="54" />
+            <Map s="..|pKa_ThreeAcids_1" id="55" />
+            <Map s="pKa_ThreeAcids_1" id="56" />
+            <Map s="..|pKa_TwoAcids_1" id="57" />
+            <Map s="pKa_TwoAcids_1" id="58" />
+            <Map s="..|Is triprotic acid" id="59" />
+            <Map s="IsTriproticAcid" id="60" />
+            <Map s="..|CT_ACID" id="61" />
+            <Map s="CT_ACID" id="62" />
+            <Map s="CT0" id="63" />
+            <Map s="CT1" id="64" />
+            <Map s="CT2" id="65" />
+            <Map s="..|pKa_OneBase_0" id="66" />
+            <Map s="pKa_OneBase_0" id="67" />
+            <Map s="..|pKa_ThreeBases_0" id="68" />
+            <Map s="pKa_ThreeBases_0" id="69" />
+            <Map s="..|pKa_TwoBases_0" id="70" />
+            <Map s="pKa_TwoBases_0" id="71" />
+            <Map s="..|pKa_ThreeBases_1" id="72" />
+            <Map s="pKa_ThreeBases_1" id="73" />
+            <Map s="..|pKa_TwoBases_1" id="74" />
+            <Map s="pKa_TwoBases_1" id="75" />
+            <Map s="..|Is triprotic base" id="76" />
+            <Map s="IsTriproticBase" id="77" />
+            <Map s="..|CT_BASE" id="78" />
+            <Map s="CT_BASE" id="79" />
+            <Map s="..|CT_NEUTRAL" id="80" />
+            <Map s="CT_NEUTRAL" id="81" />
+            <Map s="..|Reference pH" id="82" />
+            <Map s="pH" id="83" />
+            <Map s="..|pKa_pH_WS_sol_F1" id="84" />
+            <Map s="F1" id="85" />
+            <Map s="..|pKa_pH_WS_sol_F2" id="86" />
+            <Map s="F2" id="87" />
+            <Map s="..|pKa_pH_WS_sol_F3" id="88" />
+            <Map s="F3" id="89" />
+            <Map s="..|pKa_Acid_0" id="90" />
+            <Map s="pKa_Acid_0" id="91" />
+            <Map s="..|pKa_Acid_2" id="92" />
+            <Map s="pKa_Acid_2" id="93" />
+            <Map s="..|pKa_Base_0" id="94" />
+            <Map s="pKa_Base_0" id="95" />
+            <Map s="..|pKa_Base_2" id="96" />
+            <Map s="pKa_Base_2" id="97" />
+            <Map s="..|Solubility gain per charge" id="98" />
+            <Map s="base" id="99" />
+            <Map s="..|pKa_pH_WS_sol_K1" id="100" />
+            <Map s="K1" id="101" />
+            <Map s="..|pKa_pH_WS_sol_K2" id="102" />
+            <Map s="K2" id="103" />
+            <Map s="..|pKa_pH_WS_sol_K3" id="104" />
+            <Map s="K3" id="105" />
+            <Map s="..|pKa_pH_WS_sol_K4" id="106" />
+            <Map s="K4" id="107" />
+            <Map s="..|pKa_pH_WS_sol_K5" id="108" />
+            <Map s="K5" id="109" />
+            <Map s="..|pKa_pH_WS_sol_K6" id="110" />
+            <Map s="K6" id="111" />
+            <Map s="..|pKa_pH_WS_sol_K7" id="112" />
+            <Map s="K7" id="113" />
+            <Map s="..|pKa_pH_WS_sol_K8" id="114" />
+            <Map s="K8" id="115" />
+            <Map s="Start amount" id="116" />
+            <Map s="M_0" id="117" />
+            <Map s="Amount" id="118" />
+            <Map s=".." id="119" />
+            <Map s="M" id="120" />
+            <Map s="..|..|Volume" id="121" />
+            <Map s="V" id="122" />
+          </StringMap>
+        </FormulaCache>
+      </Molecules>
+      <Observers id="4fIXJKxasUufoZn-ABIwiw" name="Sim" icon="Observer" bbVersion="0">
+        <Creation createdAt="5248777815990604820" createdBy="Michael" creationMode="New" origin="PKSim" version="9.0" internalVersion="77" />
+        <Builders>
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+              <DescriptorConditions>
+                <MatchTagCondition tag="PeripheralVenousBlood" />
+              </DescriptorConditions>
+            </ContainerCriteria>
+            <MoleculeList forAll="0">
+              <MoleculeNames>
+                <MoleculeNamesChild>Aciclovir</MoleculeNamesChild>
+              </MoleculeNames>
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+          </ContainerObserverBuilder>
+          <AmountObserverBuilder id="KWz0miTqm0yv9Dt5t1TMtg" name="Concentration in container" icon="Observer" dimension="Concentration (molar)" formula="NKNACCxhwkSZetKtls3dHA">
+            <ContainerCriteria>
+              <DescriptorConditions>
+                <NotMatchTagCondition tag="Gallbladder" />
+                <NotMatchTagCondition tag="LumenSegment" />
+              </DescriptorConditions>
+            </ContainerCriteria>
+            <MoleculeList forAll="1">
+              <MoleculeNames>
+                <MoleculeNamesChild>Aciclovir</MoleculeNamesChild>
+                <MoleculeNamesChild>CYP344</MoleculeNamesChild>
+              </MoleculeNames>
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+          </AmountObserverBuilder>
+          <ContainerObserverBuilder id="-uqzA5FBAk2w5tekUkaYnw" name="Concentration in container (Liver, BloodCells)" icon="Observer" dimension="Concentration (molar)" formula="qmFGsOsE2UW7QR8qvsQCDg">
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+              <DescriptorConditions>
+                <MatchTagCondition tag="BloodCells" />
+                <MatchTagCondition tag="Liver" />
+                <NotMatchTagCondition tag="Pericentral" />
+                <NotMatchTagCondition tag="Periportal" />
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+                <MoleculeNamesChild>Aciclovir</MoleculeNamesChild>
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+            <ContainerCriteria>
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+                <MatchTagCondition tag="Interstitial" />
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+              <DescriptorConditions>
+                <MatchTagCondition tag="Intracellular" />
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+                <NotMatchTagCondition tag="Periportal" />
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+                <NotMatchTagCondition tag="Pericentral" />
+                <NotMatchTagCondition tag="Periportal" />
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+                <MatchTagCondition tag="Feces" />
+                <MatchTagCondition tag="LumenSegment" />
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+              <MoleculeNames>
+                <MoleculeNamesChild>Aciclovir</MoleculeNamesChild>
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+                <NotMatchTagCondition tag="Feces" />
+                <MatchTagCondition tag="LumenSegment" />
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+            <MoleculeList forAll="0">
+              <MoleculeNames>
+                <MoleculeNamesChild>Aciclovir</MoleculeNamesChild>
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+              <MoleculeNames>
+                <MoleculeNamesChild>Aciclovir</MoleculeNamesChild>
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+          <ContainerObserverBuilder id="RXy-vPLKiUWAjRm5wP4FvQ" name="Fraction of oral drug mass absorbed into mucosa" icon="Observer" dimension="Fraction" formula="gnhuwkMbmEKvsVz7A8a0Vg">
+            <ContainerCriteria>
+              <DescriptorConditions>
+                <MatchTagCondition tag="Lumen" />
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+              <MoleculeNames>
+                <MoleculeNamesChild>Aciclovir</MoleculeNamesChild>
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+          <ContainerObserverBuilder id="Mz4AOVk6cEyxs-kvtoMdog" name="Fraction of oral drug mass absorbed into mucosa segment" icon="Observer" dimension="Fraction" formula="UPr1xzEqOkOlK-ce8z1DHw">
+            <ContainerCriteria>
+              <DescriptorConditions>
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+                <MatchTagCondition tag="LumenSegment" />
+                <NotMatchTagCondition tag="Stomach" />
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+              <MoleculeNames>
+                <MoleculeNamesChild>Aciclovir</MoleculeNamesChild>
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+              <DescriptorConditions>
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+              <DescriptorConditions>
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+                <NotMatchTagCondition tag="Endosome" />
+                <NotMatchTagCondition tag="Gallbladder" />
+                <NotMatchTagCondition tag="Interstitial" />
+                <NotMatchTagCondition tag="Intracellular" />
+                <MatchTagCondition tag="Liver" />
+                <NotMatchTagCondition tag="Pericentral" />
+                <NotMatchTagCondition tag="Periportal" />
+                <NotMatchTagCondition tag="Plasma" />
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+            <MoleculeList forAll="0">
+              <MoleculeNames>
+                <MoleculeNamesChild>Aciclovir</MoleculeNamesChild>
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+          </ContainerObserverBuilder>
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+            <ContainerCriteria>
+              <DescriptorConditions>
+                <MatchTagCondition tag="TissueOrgan" />
+              </DescriptorConditions>
+            </ContainerCriteria>
+            <MoleculeList forAll="0">
+              <MoleculeNames>
+                <MoleculeNamesChild>Aciclovir</MoleculeNamesChild>
+              </MoleculeNames>
+            </MoleculeList>
+          </ContainerObserverBuilder>
+          <ContainerObserverBuilder id="mujBmCIsNUevm4nS7tg9Vw" name="Intracellular Unbound (Liver)" icon="Observer" dimension="Concentration (molar)" formula="Fg7P3bae8kW5gzs_GfPbVw">
+            <ContainerCriteria>
+              <DescriptorConditions>
+                <NotMatchTagCondition tag="BloodCells" />
+                <NotMatchTagCondition tag="Endosome" />
+                <NotMatchTagCondition tag="Gallbladder" />
+                <NotMatchTagCondition tag="Interstitial" />
+                <NotMatchTagCondition tag="Intracellular" />
+                <MatchTagCondition tag="Liver" />
+                <NotMatchTagCondition tag="Pericentral" />
+                <NotMatchTagCondition tag="Periportal" />
+                <NotMatchTagCondition tag="Plasma" />
+              </DescriptorConditions>
+            </ContainerCriteria>
+            <MoleculeList forAll="0">
+              <MoleculeNames>
+                <MoleculeNamesChild>Aciclovir</MoleculeNamesChild>
+              </MoleculeNames>
+            </MoleculeList>
+          </ContainerObserverBuilder>
+          <ContainerObserverBuilder id="wVmBb-5UekehNlUQDzadtQ" name="Plasma (Peripheral Venous Blood)" icon="Observer" dimension="Concentration (molar)" formula="gIqm_jZQMUCFH0eg8aW1iw">
+            <ContainerCriteria>
+              <DescriptorConditions>
+                <MatchTagCondition tag="PeripheralVenousBlood" />
+              </DescriptorConditions>
+            </ContainerCriteria>
+            <MoleculeList forAll="1">
+              <MoleculeNames>
+                <MoleculeNamesChild>Aciclovir</MoleculeNamesChild>
+              </MoleculeNames>
+            </MoleculeList>
+          </ContainerObserverBuilder>
+          <AmountObserverBuilder id="h5gY_X2JXUqhu8uFzK0f6w" name="Plasma Unbound" icon="Observer" dimension="Concentration (molar)" formula="AgBzkxT-iE2cELxixWBusA">
+            <ContainerCriteria>
+              <DescriptorConditions>
+                <MatchTagCondition tag="BloodOrgan" />
+                <MatchTagCondition tag="Plasma" />
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+            </ContainerCriteria>
+            <MoleculeList forAll="0">
+              <MoleculeNames>
+                <MoleculeNamesChild>Aciclovir</MoleculeNamesChild>
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+            </MoleculeList>
+          </AmountObserverBuilder>
+          <ContainerObserverBuilder id="8S2P-ji3TkiLyaB2l-17Tw" name="Plasma Unbound (Peripheral Venous Blood)" icon="Observer" dimension="Concentration (molar)" formula="1cv22Kn7j0OmQzyAd0y3rA">
+            <ContainerCriteria>
+              <DescriptorConditions>
+                <MatchTagCondition tag="PeripheralVenousBlood" />
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+            </ContainerCriteria>
+            <MoleculeList forAll="1">
+              <MoleculeNames>
+                <MoleculeNamesChild>Aciclovir</MoleculeNamesChild>
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+            </MoleculeList>
+          </ContainerObserverBuilder>
+          <ContainerObserverBuilder id="S1VMJTuZjkGU0lHM-OeNPw" name="Tissue" icon="Observer" dimension="Concentration (molar)" formula="qxZX8s7daEiG3y6-1Zxjyw">
+            <ContainerCriteria>
+              <DescriptorConditions>
+                <NotMatchTagCondition tag="LargeIntestine" />
+                <NotMatchTagCondition tag="SmallIntestine" />
+                <MatchTagCondition tag="TissueOrgan" />
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+            </ContainerCriteria>
+            <MoleculeList forAll="1">
+              <MoleculeNames>
+                <MoleculeNamesChild>Aciclovir</MoleculeNamesChild>
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+          <ContainerObserverBuilder id="fRZi_kqfVkWcC7DyO1ldUw" name="Tissue (Liver)" icon="Observer" dimension="Concentration (molar)" formula="TotAik474Ue4f2cE_HYafQ">
+            <ContainerCriteria>
+              <DescriptorConditions>
+                <NotMatchTagCondition tag="BloodCells" />
+                <NotMatchTagCondition tag="Endosome" />
+                <NotMatchTagCondition tag="Gallbladder" />
+                <NotMatchTagCondition tag="Interstitial" />
+                <NotMatchTagCondition tag="Intracellular" />
+                <NotMatchTagCondition tag="LargeIntestine" />
+                <MatchTagCondition tag="Liver" />
+                <NotMatchTagCondition tag="Pericentral" />
+                <NotMatchTagCondition tag="Periportal" />
+                <NotMatchTagCondition tag="Plasma" />
+                <NotMatchTagCondition tag="SmallIntestine" />
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+            </ContainerCriteria>
+            <MoleculeList forAll="0">
+              <MoleculeNames>
+                <MoleculeNamesChild>Aciclovir</MoleculeNamesChild>
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+          <ContainerObserverBuilder id="mjxGt4kd70CscOGaMJTk1A" name="Total Tissue (Large Intestine)" icon="Observer" dimension="Concentration (molar)" formula="qc5f1kAAfkmiLzAsk7pWNg">
+            <ContainerCriteria>
+              <DescriptorConditions>
+                <MatchTagCondition tag="LargeIntestine" />
+                <MatchTagCondition tag="TissueOrgan" />
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+            </ContainerCriteria>
+            <MoleculeList forAll="0">
+              <MoleculeNames>
+                <MoleculeNamesChild>Aciclovir</MoleculeNamesChild>
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+          </ContainerObserverBuilder>
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+            <ContainerCriteria>
+              <DescriptorConditions>
+                <MatchTagCondition tag="SmallIntestine" />
+                <MatchTagCondition tag="TissueOrgan" />
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+            <MoleculeList forAll="0">
+              <MoleculeNames>
+                <MoleculeNamesChild>Aciclovir</MoleculeNamesChild>
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+          <ContainerObserverBuilder id="vsGVEHvgQECMekpAq8obqQ" name="Whole Blood" icon="Observer" dimension="Concentration (molar)" formula="7bJ8l2xdv0iw3K3M4H8-hw">
+            <ContainerCriteria>
+              <DescriptorConditions>
+                <NotMatchTagCondition tag="BloodCells" />
+                <MatchTagCondition tag="BloodOrgan" />
+                <NotMatchTagCondition tag="Plasma" />
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+            </ContainerCriteria>
+            <MoleculeList forAll="0">
+              <MoleculeNames>
+                <MoleculeNamesChild>Aciclovir</MoleculeNamesChild>
+              </MoleculeNames>
+            </MoleculeList>
+          </ContainerObserverBuilder>
+          <ContainerObserverBuilder id="XmqmFC8O_EOHE6gmcy6VPA" name="Whole Blood (Peripheral Venous Blood)" icon="Observer" dimension="Concentration (molar)" formula="bTvWJ9tuKkOHiR97NP8jAQ">
+            <ContainerCriteria>
+              <DescriptorConditions>
+                <MatchTagCondition tag="PeripheralVenousBlood" />
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+            </ContainerCriteria>
+            <MoleculeList forAll="0">
+              <MoleculeNames>
+                <MoleculeNamesChild>Aciclovir</MoleculeNamesChild>
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+          </ContainerObserverBuilder>
+          <AmountObserverBuilder id="zy4JZvrLyU6-li6T0P8HSA" name="Fraction excreted to urine" icon="Observer" dimension="Fraction" formula="QRJGgMbS0Uy_B-sTFMHKuQ">
+            <ContainerCriteria>
+              <DescriptorConditions>
+                <MatchTagCondition tag="Urine" />
+              </DescriptorConditions>
+            </ContainerCriteria>
+            <MoleculeList forAll="1">
+              <MoleculeNames>
+                <MoleculeNamesChild>Aciclovir</MoleculeNamesChild>
+              </MoleculeNames>
+            </MoleculeList>
+          </AmountObserverBuilder>
+          <AmountObserverBuilder id="H7X-HONCdkWjnR80KLg0Tw" name="Fraction excreted to bile" icon="Observer" dimension="Fraction" formula="jIxG9Bifr0WtSKWte6deXw">
+            <ContainerCriteria>
+              <DescriptorConditions>
+                <MatchTagCondition tag="Gallbladder" />
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+            </ContainerCriteria>
+            <MoleculeList forAll="0">
+              <MoleculeNames>
+                <MoleculeNamesChild>Aciclovir</MoleculeNamesChild>
+              </MoleculeNames>
+            </MoleculeList>
+          </AmountObserverBuilder>
+          <AmountObserverBuilder id="R62tu20CZ0yzlzmW05jeHA" name="Fraction excreted to feces" icon="Observer" dimension="Fraction" formula="w3tXO7B1JECe386IDraqvA">
+            <ContainerCriteria>
+              <DescriptorConditions>
+                <MatchTagCondition tag="Feces" />
+              </DescriptorConditions>
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+            <MoleculeList forAll="0">
+              <MoleculeNames>
+                <MoleculeNamesChild>Aciclovir</MoleculeNamesChild>
+              </MoleculeNames>
+            </MoleculeList>
+          </AmountObserverBuilder>
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+        <FormulaCache>
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+              <Paths>
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+              <Paths>
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+            <Formula id="G8cqYXr53kCd0CioNqKLCQ" name="OBS_LumenConcentration" dim="Concentration (molar)" formula="EffectiveLumenConcentration">
+              <Paths>
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+              <Paths>
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+              <Paths>
+                <Path path="88" as="92" dim="24" />
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+            </Formula>
+            <Formula id="UPr1xzEqOkOlK-ce8z1DHw" name="OBS_FractionAbsorbedToMucosaSegment" dim="Fraction" formula="OralDrugMass&gt;0.0 ?  MassAbsorbed/OralDrugMass : 0">
+              <Paths>
+                <Path path="94" as="92" dim="24" />
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+            <Formula id="KDcknkKUXEKoSAj4DezFJg" name="OBS_InterstitialUnbound" dim="Concentration (molar)" formula="C_int * K_water_int">
+              <Paths>
+                <Path path="95" as="96" dim="2" />
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+            <Formula id="dj_LlNX1IUaposEZGRFF0w" name="OBS_InterstitialUnbound_liv" dim="Concentration (molar)" formula="(C_int_prp * K_water_int_prp * V_int_prp + C_int_prc * K_water_int_prc * V_int_prc)/(V_int_prp+V_int_prc)">
+              <Paths>
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+            <Formula id="2gRXFQukXUGrUdhBCEovQA" name="OBS_IntracellularUnbound" dim="Concentration (molar)" formula="C_cell * K_water_cell">
+              <Paths>
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+              <Paths>
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+            <Formula id="AgBzkxT-iE2cELxixWBusA" name="OBS_PlasmaUnbound" dim="Concentration (molar)" formula="C_pls*fu">
+              <Paths>
+                <Path path="121" as="122" dim="2" />
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+            </Formula>
+            <Formula id="1cv22Kn7j0OmQzyAd0y3rA" name="OBS_PlasmaUnbound_PeripheralVenousBlood" dim="Concentration (molar)" formula="(fQ_art*C_pls_art+fQ_bon*C_pls_bon+fQ_fat*C_pls_fat+fQ_mus*C_pls_mus+fQ_skn*C_pls_skn)*fu">
+              <Paths>
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+            <Formula id="qxZX8s7daEiG3y6-1Zxjyw" name="OBS_Tissue" dim="Concentration (molar)" formula="(f_int*C_int+f_cell*C_cell)/(f_int+f_cell)">
+              <Paths>
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+            <Formula id="TotAik474Ue4f2cE_HYafQ" name="OBS_Tissue_liv" dim="Concentration (molar)" formula="(C_int_prp * V_int_prp + C_int_prc * V_int_prc + C_cell_prp * V_cell_prp + C_cell_prc * V_cell_prc)/(V_int_prp+V_int_prc+V_cell_prp)">
+              <Paths>
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+              <Paths>
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+                <Path path="201" as="202" dim="27" />
+                <Path path="203" as="204" dim="27" />
+                <Path path="205" as="206" dim="27" />
+                <Path path="207" as="158" dim="24" />
+                <Path path="208" as="209" dim="24" />
+                <Path path="210" as="211" dim="24" />
+                <Path path="212" as="213" dim="24" />
+                <Path path="214" as="215" dim="24" />
+                <Path path="216" as="217" dim="24" />
+                <Path path="218" as="172" dim="24" />
+                <Path path="219" as="220" dim="24" />
+                <Path path="221" as="222" dim="24" />
+                <Path path="223" as="224" dim="24" />
+                <Path path="225" as="226" dim="24" />
+                <Path path="227" as="228" dim="24" />
+              </Paths>
+            </Formula>
+            <Formula id="7bJ8l2xdv0iw3K3M4H8-hw" name="OBS_WholeBlood" dim="Concentration (molar)" formula="(1 - HCT) * C_pls+HCT * C_bc">
+              <Paths>
+                <Path path="229" as="230" dim="2" />
+                <Path path="231" as="122" dim="2" />
+                <Path path="232" as="233" />
+              </Paths>
+            </Formula>
+            <Formula id="bTvWJ9tuKkOHiR97NP8jAQ" name="OBS_WholeBlood_PeripheralVenousBlood" dim="Concentration (molar)" formula="(1-HCT)*(fQ_art*C_pls_art+fQ_bon*C_pls_bon+fQ_fat*C_pls_fat+fQ_mus*C_pls_mus+fQ_skn*C_pls_skn) + HCT*(fQ_art*C_bc_art+fQ_bon*C_bc_bon+fQ_fat*C_bc_fat+fQ_mus*C_bc_mus+fQ_skn*C_bc_skn)">
+              <Paths>
+                <Path path="0" as="1" dim="2" />
+                <Path path="3" as="4" dim="2" />
+                <Path path="5" as="6" dim="2" />
+                <Path path="7" as="8" dim="2" />
+                <Path path="9" as="10" dim="2" />
+                <Path path="111" as="112" dim="2" />
+                <Path path="113" as="114" dim="2" />
+                <Path path="115" as="116" dim="2" />
+                <Path path="117" as="118" dim="2" />
+                <Path path="119" as="120" dim="2" />
+                <Path path="11" as="12" dim="13" />
+                <Path path="14" as="15" dim="13" />
+                <Path path="16" as="17" dim="13" />
+                <Path path="18" as="19" dim="13" />
+                <Path path="20" as="21" dim="13" />
+                <Path path="232" as="233" />
+              </Paths>
+            </Formula>
+            <Formula id="QRJGgMbS0Uy_B-sTFMHKuQ" name="FractionObserver" dim="Fraction" formula="TotalDrugMass&gt;0 ? M/TotalDrugMass : 0">
+              <Paths>
+                <Path path="22" as="23" dim="24" />
+                <Path path="234" as="235" dim="24" />
+              </Paths>
+            </Formula>
+            <Formula id="jIxG9Bifr0WtSKWte6deXw" name="FractionObserver" dim="Fraction" formula="TotalDrugMass&gt;0 ? M/TotalDrugMass : 0">
+              <Paths>
+                <Path path="22" as="23" dim="24" />
+                <Path path="234" as="235" dim="24" />
+              </Paths>
+            </Formula>
+            <Formula id="w3tXO7B1JECe386IDraqvA" name="FractionObserver" dim="Fraction" formula="TotalDrugMass&gt;0 ? M/TotalDrugMass : 0">
+              <Paths>
+                <Path path="22" as="23" dim="24" />
+                <Path path="234" as="235" dim="24" />
+              </Paths>
+            </Formula>
+          </Formulas>
+          <StringMap>
+            <Map s="Organism|ArterialBlood|BloodCells|MOLECULE|Concentration" id="0" />
+            <Map s="C_bc_art" id="1" />
+            <Map s="Concentration (molar)" id="2" />
+            <Map s="Organism|Bone|BloodCells|MOLECULE|Concentration" id="3" />
+            <Map s="C_bc_bon" id="4" />
+            <Map s="Organism|Fat|BloodCells|MOLECULE|Concentration" id="5" />
+            <Map s="C_bc_fat" id="6" />
+            <Map s="Organism|Muscle|BloodCells|MOLECULE|Concentration" id="7" />
+            <Map s="C_bc_mus" id="8" />
+            <Map s="Organism|Skin|BloodCells|MOLECULE|Concentration" id="9" />
+            <Map s="C_bc_skn" id="10" />
+            <Map s="Organism|ArterialBlood|Peripheral blood flow fraction" id="11" />
+            <Map s="fQ_art" id="12" />
+            <Map s="Fraction" id="13" />
+            <Map s="Organism|Bone|Peripheral blood flow fraction" id="14" />
+            <Map s="fQ_bon" id="15" />
+            <Map s="Organism|Fat|Peripheral blood flow fraction" id="16" />
+            <Map s="fQ_fat" id="17" />
+            <Map s="Organism|Muscle|Peripheral blood flow fraction" id="18" />
+            <Map s="fQ_mus" id="19" />
+            <Map s="Organism|Skin|Peripheral blood flow fraction" id="20" />
+            <Map s="fQ_skn" id="21" />
+            <Map s=".." id="22" />
+            <Map s="M" id="23" />
+            <Map s="Amount" id="24" />
+            <Map s="..|..|Volume" id="25" />
+            <Map s="V" id="26" />
+            <Map s="Volume" id="27" />
+            <Map s="Organism|Liver|Pericentral|BloodCells|Volume" id="28" />
+            <Map s="V_bc_prc" id="29" />
+            <Map s="Organism|Liver|Periportal|BloodCells|Volume" id="30" />
+            <Map s="V_bc_prp" id="31" />
+            <Map s="Organism|Liver|Pericentral|BloodCells|MOLECULE|Concentration" id="32" />
+            <Map s="C_bc_prc" id="33" />
+            <Map s="Organism|Liver|Periportal|BloodCells|MOLECULE|Concentration" id="34" />
+            <Map s="C_bc_prp" id="35" />
+            <Map s="Organism|Liver|Pericentral|Interstitial|Volume" id="36" />
+            <Map s="V_int_prc" id="37" />
+            <Map s="Organism|Liver|Periportal|Interstitial|Volume" id="38" />
+            <Map s="V_int_prp" id="39" />
+            <Map s="Organism|Liver|Pericentral|Interstitial|MOLECULE|Concentration" id="40" />
+            <Map s="C_int_prc" id="41" />
+            <Map s="Organism|Liver|Periportal|Interstitial|MOLECULE|Concentration" id="42" />
+            <Map s="C_int_prp" id="43" />
+            <Map s="Organism|Liver|Pericentral|Intracellular|Volume" id="44" />
+            <Map s="V_cell_prc" id="45" />
+            <Map s="Organism|Liver|Periportal|Intracellular|Volume" id="46" />
+            <Map s="V_cell_prp" id="47" />
+            <Map s="Organism|Liver|Pericentral|Intracellular|MOLECULE|Concentration" id="48" />
+            <Map s="C_cell_prc" id="49" />
+            <Map s="Organism|Liver|Periportal|Intracellular|MOLECULE|Concentration" id="50" />
+            <Map s="C_cell_prp" id="51" />
+            <Map s="Organism|Liver|Pericentral|Plasma|Volume" id="52" />
+            <Map s="V_pls_prc" id="53" />
+            <Map s="Organism|Liver|Periportal|Plasma|Volume" id="54" />
+            <Map s="V_pls_prp" id="55" />
+            <Map s="Organism|Liver|Pericentral|Plasma|MOLECULE|Concentration" id="56" />
+            <Map s="C_pls_prc" id="57" />
+            <Map s="Organism|Liver|Periportal|Plasma|MOLECULE|Concentration" id="58" />
+            <Map s="C_pls_prp" id="59" />
+            <Map s="..|Effective concentration in lumen" id="60" />
+            <Map s="EffectiveLumenConcentration" id="61" />
+            <Map s="Organism|Lumen|Caecum|MOLECULE" id="62" />
+            <Map s="M_cae" id="63" />
+            <Map s="Organism|Lumen|ColonAscendens|MOLECULE" id="64" />
+            <Map s="M_colasc" id="65" />
+            <Map s="Organism|Lumen|ColonDescendens|MOLECULE" id="66" />
+            <Map s="M_coldesc" id="67" />
+            <Map s="Organism|Lumen|ColonSigmoid|MOLECULE" id="68" />
+            <Map s="M_colsigm" id="69" />
+            <Map s="Organism|Lumen|ColonTransversum|MOLECULE" id="70" />
+            <Map s="M_coltrans" id="71" />
+            <Map s="Organism|Lumen|Duodenum|MOLECULE" id="72" />
+            <Map s="M_duo" id="73" />
+            <Map s="Organism|Lumen|Feces|MOLECULE" id="74" />
+            <Map s="M_fec" id="75" />
+            <Map s="Organism|Lumen|LowerIleum|MOLECULE" id="76" />
+            <Map s="M_lil" id="77" />
+            <Map s="Organism|Lumen|LowerJejunum|MOLECULE" id="78" />
+            <Map s="M_lje" id="79" />
+            <Map s="Organism|Lumen|Rectum|MOLECULE" id="80" />
+            <Map s="M_rect" id="81" />
+            <Map s="Organism|Lumen|Stomach|MOLECULE" id="82" />
+            <Map s="M_sto" id="83" />
+            <Map s="Organism|Lumen|UpperIleum|MOLECULE" id="84" />
+            <Map s="M_uil" id="85" />
+            <Map s="Organism|Lumen|UpperJejunum|MOLECULE" id="86" />
+            <Map s="M_uje" id="87" />
+            <Map s="Neighborhoods|Lumen_sto_Lumen_duo|MOLECULE|Oral mass absorbed" id="88" />
+            <Map s="Mabs_Mucosa" id="89" />
+            <Map s="MOLECULE|Total oral drug mass" id="90" />
+            <Map s="TotalOralDrugMass" id="91" />
+            <Map s="MassAbsorbed" id="92" />
+            <Map s="OralDrugMass" id="93" />
+            <Map s="..|Oral mass absorbed segment" id="94" />
+            <Map s="..|..|Interstitial|MOLECULE|Concentration" id="95" />
+            <Map s="C_int" id="96" />
+            <Map s="..|..|Interstitial|MOLECULE|Partition coefficient (water/container)" id="97" />
+            <Map s="K_water_int" id="98" />
+            <Map s="Organism|Liver|Pericentral|Interstitial|MOLECULE|Partition coefficient (water/container)" id="99" />
+            <Map s="K_water_int_prc" id="100" />
+            <Map s="Organism|Liver|Periportal|Interstitial|MOLECULE|Partition coefficient (water/container)" id="101" />
+            <Map s="K_water_int_prp" id="102" />
+            <Map s="..|..|Intracellular|MOLECULE|Concentration" id="103" />
+            <Map s="C_cell" id="104" />
+            <Map s="..|..|Intracellular|MOLECULE|Partition coefficient (water/container)" id="105" />
+            <Map s="K_water_cell" id="106" />
+            <Map s="Organism|Liver|Pericentral|Intracellular|MOLECULE|Partition coefficient (water/container)" id="107" />
+            <Map s="K_water_cell_prc" id="108" />
+            <Map s="Organism|Liver|Periportal|Intracellular|MOLECULE|Partition coefficient (water/container)" id="109" />
+            <Map s="K_water_cell_prp" id="110" />
+            <Map s="Organism|ArterialBlood|Plasma|MOLECULE|Concentration" id="111" />
+            <Map s="C_pls_art" id="112" />
+            <Map s="Organism|Bone|Plasma|MOLECULE|Concentration" id="113" />
+            <Map s="C_pls_bon" id="114" />
+            <Map s="Organism|Fat|Plasma|MOLECULE|Concentration" id="115" />
+            <Map s="C_pls_fat" id="116" />
+            <Map s="Organism|Muscle|Plasma|MOLECULE|Concentration" id="117" />
+            <Map s="C_pls_mus" id="118" />
+            <Map s="Organism|Skin|Plasma|MOLECULE|Concentration" id="119" />
+            <Map s="C_pls_skn" id="120" />
+            <Map s="..|Concentration" id="121" />
+            <Map s="C_pls" id="122" />
+            <Map s="MOLECULE|Fraction unbound (plasma)" id="123" />
+            <Map s="fu" id="124" />
+            <Map s="..|..|Fraction interstitial" id="125" />
+            <Map s="f_int" id="126" />
+            <Map s="..|..|Fraction intracellular" id="127" />
+            <Map s="f_cell" id="128" />
+            <Map s="Organism|LargeIntestine|Interstitial|Volume" id="129" />
+            <Map s="V_int" id="130" />
+            <Map s="Organism|LargeIntestine|Mucosa|Caecum|Interstitial|Volume" id="131" />
+            <Map s="V_int_cae" id="132" />
+            <Map s="Organism|LargeIntestine|Mucosa|ColonAscendens|Interstitial|Volume" id="133" />
+            <Map s="V_int_colasc" id="134" />
+            <Map s="Organism|LargeIntestine|Mucosa|ColonDescendens|Interstitial|Volume" id="135" />
+            <Map s="V_int_coldesc" id="136" />
+            <Map s="Organism|LargeIntestine|Mucosa|ColonSigmoid|Interstitial|Volume" id="137" />
+            <Map s="V_int_colsigm" id="138" />
+            <Map s="Organism|LargeIntestine|Mucosa|ColonTransversum|Interstitial|Volume" id="139" />
+            <Map s="V_int_coltrans" id="140" />
+            <Map s="Organism|LargeIntestine|Mucosa|Rectum|Interstitial|Volume" id="141" />
+            <Map s="V_int_rect" id="142" />
+            <Map s="Organism|LargeIntestine|Intracellular|Volume" id="143" />
+            <Map s="V_cell" id="144" />
+            <Map s="Organism|LargeIntestine|Mucosa|Caecum|Intracellular|Volume" id="145" />
+            <Map s="V_cell_cae" id="146" />
+            <Map s="Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|Volume" id="147" />
+            <Map s="V_cell_colasc" id="148" />
+            <Map s="Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|Volume" id="149" />
+            <Map s="V_cell_coldesc" id="150" />
+            <Map s="Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|Volume" id="151" />
+            <Map s="V_cell_colsigm" id="152" />
+            <Map s="Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|Volume" id="153" />
+            <Map s="V_cell_coltrans" id="154" />
+            <Map s="Organism|LargeIntestine|Mucosa|Rectum|Intracellular|Volume" id="155" />
+            <Map s="V_cell_rect" id="156" />
+            <Map s="Organism|LargeIntestine|Intracellular|MOLECULE" id="157" />
+            <Map s="M_cell" id="158" />
+            <Map s="Organism|LargeIntestine|Mucosa|Caecum|Intracellular|MOLECULE" id="159" />
+            <Map s="M_cell_cae" id="160" />
+            <Map s="Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|MOLECULE" id="161" />
+            <Map s="M_cell_colasc" id="162" />
+            <Map s="Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|MOLECULE" id="163" />
+            <Map s="M_cell_coldesc" id="164" />
+            <Map s="Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|MOLECULE" id="165" />
+            <Map s="M_cell_colsigm" id="166" />
+            <Map s="Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|MOLECULE" id="167" />
+            <Map s="M_cell_coltrans" id="168" />
+            <Map s="Organism|LargeIntestine|Mucosa|Rectum|Intracellular|MOLECULE" id="169" />
+            <Map s="M_cell_rect" id="170" />
+            <Map s="Organism|LargeIntestine|Interstitial|MOLECULE" id="171" />
+            <Map s="M_int" id="172" />
+            <Map s="Organism|LargeIntestine|Mucosa|Caecum|Interstitial|MOLECULE" id="173" />
+            <Map s="M_int_cae" id="174" />
+            <Map s="Organism|LargeIntestine|Mucosa|ColonAscendens|Interstitial|MOLECULE" id="175" />
+            <Map s="M_int_colasc" id="176" />
+            <Map s="Organism|LargeIntestine|Mucosa|ColonDescendens|Interstitial|MOLECULE" id="177" />
+            <Map s="M_int_coldesc" id="178" />
+            <Map s="Organism|LargeIntestine|Mucosa|ColonSigmoid|Interstitial|MOLECULE" id="179" />
+            <Map s="M_int_colsigm" id="180" />
+            <Map s="Organism|LargeIntestine|Mucosa|ColonTransversum|Interstitial|MOLECULE" id="181" />
+            <Map s="M_int_coltrans" id="182" />
+            <Map s="Organism|LargeIntestine|Mucosa|Rectum|Interstitial|MOLECULE" id="183" />
+            <Map s="M_int_rect" id="184" />
+            <Map s="Organism|SmallIntestine|Interstitial|Volume" id="185" />
+            <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Interstitial|Volume" id="186" />
+            <Map s="V_int_duo" id="187" />
+            <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Interstitial|Volume" id="188" />
+            <Map s="V_int_lil" id="189" />
+            <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Interstitial|Volume" id="190" />
+            <Map s="V_int_lje" id="191" />
+            <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Interstitial|Volume" id="192" />
+            <Map s="V_int_uil" id="193" />
+            <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Interstitial|Volume" id="194" />
+            <Map s="V_int_uje" id="195" />
+            <Map s="Organism|SmallIntestine|Intracellular|Volume" id="196" />
+            <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|Volume" id="197" />
+            <Map s="V_cell_duo" id="198" />
+            <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|Volume" id="199" />
+            <Map s="V_cell_lil" id="200" />
+            <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|Volume" id="201" />
+            <Map s="V_cell_lje" id="202" />
+            <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|Volume" id="203" />
+            <Map s="V_cell_uil" id="204" />
+            <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|Volume" id="205" />
+            <Map s="V_cell_uje" id="206" />
+            <Map s="Organism|SmallIntestine|Intracellular|MOLECULE" id="207" />
+            <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|MOLECULE" id="208" />
+            <Map s="M_cell_duo" id="209" />
+            <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|MOLECULE" id="210" />
+            <Map s="M_cell_lil" id="211" />
+            <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|MOLECULE" id="212" />
+            <Map s="M_cell_lje" id="213" />
+            <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|MOLECULE" id="214" />
+            <Map s="M_cell_uil" id="215" />
+            <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|MOLECULE" id="216" />
+            <Map s="M_cell_uje" id="217" />
+            <Map s="Organism|SmallIntestine|Interstitial|MOLECULE" id="218" />
+            <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Interstitial|MOLECULE" id="219" />
+            <Map s="M_int_duo" id="220" />
+            <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Interstitial|MOLECULE" id="221" />
+            <Map s="M_int_lil" id="222" />
+            <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Interstitial|MOLECULE" id="223" />
+            <Map s="M_int_lje" id="224" />
+            <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Interstitial|MOLECULE" id="225" />
+            <Map s="M_int_uil" id="226" />
+            <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Interstitial|MOLECULE" id="227" />
+            <Map s="M_int_uje" id="228" />
+            <Map s="..|..|BloodCells|MOLECULE|Concentration" id="229" />
+            <Map s="C_bc" id="230" />
+            <Map s="..|..|Plasma|MOLECULE|Concentration" id="231" />
+            <Map s="Organism|Hematocrit" id="232" />
+            <Map s="HCT" id="233" />
+            <Map s="MOLECULE|Total drug mass" id="234" />
+            <Map s="TotalDrugMass" id="235" />
+          </StringMap>
+        </FormulaCache>
+      </Observers>
+      <EventGroups id="IFoeg9eJl0-ydrtSAc__mw" name="Sim" icon="EventGroup" bbVersion="0">
+        <Creation createdAt="5248777815990584855" createdBy="Michael" creationMode="New" origin="PKSim" version="9.0" internalVersion="77" />
+        <Builders>
+          <EventGroupBuilder id="chQhOsuS1EOMmCz76UlQoQ" name="Applications" icon="Applications" mode="Logical" containerType="EventGroup">
+            <Children>
+              <EventGroupBuilder id="drG5iI5I6kawPmEDD9MtWw" name="IV" mode="Logical" containerType="EventGroup">
+                <Children>
+                  <ApplicationBuilder id="jzEhCptODkipBHQptlocvA" name="Application_1" icon="IntravenousBolus" mode="Logical" containerType="Application" eventGroupType="IntravenousBolus" moleculeName="Aciclovir">
+                    <Tags>
+                      <Tag value="Application" />
+                      <Tag value="Application_1" />
+                      <Tag value="ApplicationRoot" />
+                    </Tags>
+                    <Children>
+                      <EventBuilder id="MkTQgQ07mUWbqSoD4ZDmUg" name="Application_StartEvent" description="Start event for application" oneTime="1" formula="0scNpznCS0OoY_njzeldxw">
+                        <Tags>
+                          <Tag value="Application" />
+                          <Tag value="Application_1" />
+                        </Tags>
+                        <Assignments>
+                          <EventAssignmentBuilder id="g9SeISZ4F0-Gv_SeB_Gq4Q" name="Assignment_1" useAsValue="1" dimension="Amount" formula="i8Wmc7y-n0SEIJc480xgVQ">
+                            <ObjectPath path="0" />
+                          </EventAssignmentBuilder>
+                        </Assignments>
+                      </EventBuilder>
+                      <Container id="R4c25WnbhkO4cGHZv8pvUg" name="ProtocolSchemaItem" description="Protocol Schema Item" mode="Logical" containerType="Other">
+                        <Tags>
+                          <Tag value="Application" />
+                          <Tag value="Application_1" />
+                        </Tags>
+                        <Children>
+                          <Parameter id="rA4DsfxQDEC2vYUOrF09wg" name="Start time" description="Start time of application" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0" displayUnit="h">
+                            <Info min="0" flag="58" seq="1" ref="0" bb="16" group="88" />
+                          </Parameter>
+                          <Parameter id="6c9fNvJ9lECpsW5ASQ0fRw" name="Dose" description="Dose" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="W2ddM-j8iUS3oQLMWCjqag" isDefault="1" displayUnit="mg">
+                            <Info min="0" flag="50" seq="2" ref="0" bb="2" group="88" />
+                          </Parameter>
+                          <Parameter id="3tKT9XSVMU6-ZPK-trx_EQ" name="DosePerBodySurfaceArea" description="Dose" icon="Parameter" persistable="0" isFixedValue="0" dim="Dose per body surface area" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0" displayUnit="mg/m²">
+                            <Info min="0" flag="50" seq="2" ref="0" bb="2" group="88" />
+                          </Parameter>
+                          <Parameter id="lhvlLQTbe0a6fYlE_Sqj6A" name="DosePerBodyWeight" description="Dose" icon="Parameter" persistable="0" isFixedValue="0" dim="Dose per body weight" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1E-06" displayUnit="mg/kg">
+                            <Info min="0" flag="58" seq="2" ref="0" bb="16" group="88" />
+                          </Parameter>
+                          <Parameter id="aVMKH5WvQUSobklwfwFieA" name="DrugMass" description="Drug mass of application" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" formula="AVY7rVJpJUC5GdqAokaEuQ" isDefault="1" displayUnit="µmol">
+                            <Tags>
+                              <Tag value="MOLECULE" />
+                            </Tags>
+                            <Info min="0" flag="54" seq="2" ref="0" bb="2" group="88" />
+                          </Parameter>
+                        </Children>
+                      </Container>
+                      <ApplicationMoleculeBuilder id="cUT_3XjY-0KE42Adh2og_w" name="Application_1" formula="kJrzl2mJKEmGqQwjxmeb5A">
+                        <RelativeContainerPath path="1" />
+                      </ApplicationMoleculeBuilder>
+                    </Children>
+                    <SourceCriteria>
+                      <DescriptorConditions>
+                        <MatchTagCondition tag="Applications" />
+                      </DescriptorConditions>
+                    </SourceCriteria>
+                  </ApplicationBuilder>
+                  <ApplicationBuilder id="XIqitDT42UCflJMoEn2y-A" name="Application_2" icon="IntravenousBolus" mode="Logical" containerType="Application" eventGroupType="IntravenousBolus" moleculeName="Aciclovir">
+                    <Tags>
+                      <Tag value="Application" />
+                      <Tag value="Application_2" />
+                      <Tag value="ApplicationRoot" />
+                    </Tags>
+                    <Children>
+                      <EventBuilder id="koFJ6GuDJ0G2WDfKynAAug" name="Application_StartEvent" description="Start event for application" oneTime="1" formula="0scNpznCS0OoY_njzeldxw">
+                        <Tags>
+                          <Tag value="Application" />
+                          <Tag value="Application_2" />
+                        </Tags>
+                        <Assignments>
+                          <EventAssignmentBuilder id="laa8-DzUNUu1QDNbKS59tA" name="Assignment_1" useAsValue="1" dimension="Amount" formula="i8Wmc7y-n0SEIJc480xgVQ">
+                            <ObjectPath path="0" />
+                          </EventAssignmentBuilder>
+                        </Assignments>
+                      </EventBuilder>
+                      <Container id="oayt8LX000yOH7YLNg-OaA" name="ProtocolSchemaItem" description="Protocol Schema Item" mode="Logical" containerType="Other">
+                        <Tags>
+                          <Tag value="Application" />
+                          <Tag value="Application_2" />
+                        </Tags>
+                        <Children>
+                          <Parameter id="fzWc12tHlU2BqqlMIgLXmA" name="Start time" description="Start time of application" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="480" displayUnit="h">
+                            <Info min="0" flag="58" seq="1" ref="0" bb="16" group="88" />
+                          </Parameter>
+                          <Parameter id="uFSUuQhYUkmdw7m4CzQRzw" name="Dose" description="Dose" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="W2ddM-j8iUS3oQLMWCjqag" isDefault="1" displayUnit="mg">
+                            <Info min="0" flag="50" seq="2" ref="0" bb="2" group="88" />
+                          </Parameter>
+                          <Parameter id="MerQV4jlPk20kmzBDuqqDA" name="DosePerBodySurfaceArea" description="Dose" icon="Parameter" persistable="0" isFixedValue="0" dim="Dose per body surface area" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0" displayUnit="mg/m²">
+                            <Info min="0" flag="50" seq="2" ref="0" bb="2" group="88" />
+                          </Parameter>
+                          <Parameter id="znZCif_mYkOFcvLHMcDTTg" name="DosePerBodyWeight" description="Dose" icon="Parameter" persistable="0" isFixedValue="0" dim="Dose per body weight" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1E-06" displayUnit="mg/kg">
+                            <Info min="0" flag="58" seq="2" ref="0" bb="16" group="88" />
+                          </Parameter>
+                          <Parameter id="PeUIARPsgUmeS_0W-1TN8g" name="DrugMass" description="Drug mass of application" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" formula="AVY7rVJpJUC5GdqAokaEuQ" isDefault="1" displayUnit="µmol">
+                            <Tags>
+                              <Tag value="MOLECULE" />
+                            </Tags>
+                            <Info min="0" flag="54" seq="2" ref="0" bb="2" group="88" />
+                          </Parameter>
+                        </Children>
+                      </Container>
+                      <ApplicationMoleculeBuilder id="rjP-YZQ3YUewESyuEKoItg" name="Application_2" formula="kJrzl2mJKEmGqQwjxmeb5A">
+                        <RelativeContainerPath path="2" />
+                      </ApplicationMoleculeBuilder>
+                    </Children>
+                    <SourceCriteria>
+                      <DescriptorConditions>
+                        <MatchTagCondition tag="Applications" />
+                      </DescriptorConditions>
+                    </SourceCriteria>
+                  </ApplicationBuilder>
+                  <ApplicationBuilder id="62qgmt_XpUuR-CSm7wpLog" name="Application_3" icon="IntravenousBolus" mode="Logical" containerType="Application" eventGroupType="IntravenousBolus" moleculeName="Aciclovir">
+                    <Tags>
+                      <Tag value="Application" />
+                      <Tag value="Application_3" />
+                      <Tag value="ApplicationRoot" />
+                    </Tags>
+                    <Children>
+                      <EventBuilder id="on4vb_FQtUaMtL9_Np1rQQ" name="Application_StartEvent" description="Start event for application" oneTime="1" formula="0scNpznCS0OoY_njzeldxw">
+                        <Tags>
+                          <Tag value="Application" />
+                          <Tag value="Application_3" />
+                        </Tags>
+                        <Assignments>
+                          <EventAssignmentBuilder id="LN62lQa6PEGOlDvmt_HjiQ" name="Assignment_1" useAsValue="1" dimension="Amount" formula="i8Wmc7y-n0SEIJc480xgVQ">
+                            <ObjectPath path="0" />
+                          </EventAssignmentBuilder>
+                        </Assignments>
+                      </EventBuilder>
+                      <Container id="mR__6iIs8Eu2wQokVh6SqQ" name="ProtocolSchemaItem" description="Protocol Schema Item" mode="Logical" containerType="Other">
+                        <Tags>
+                          <Tag value="Application" />
+                          <Tag value="Application_3" />
+                        </Tags>
+                        <Children>
+                          <Parameter id="AFay3My1hkSz-KpedK-P2A" name="Start time" description="Start time of application" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="960" displayUnit="h">
+                            <Info min="0" flag="58" seq="1" ref="0" bb="16" group="88" />
+                          </Parameter>
+                          <Parameter id="6boswXgIGUeUtx_M-uKt7g" name="Dose" description="Dose" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="W2ddM-j8iUS3oQLMWCjqag" isDefault="1" displayUnit="mg">
+                            <Info min="0" flag="50" seq="2" ref="0" bb="2" group="88" />
+                          </Parameter>
+                          <Parameter id="jm0oUC7DjUWx-C2YF6270g" name="DosePerBodySurfaceArea" description="Dose" icon="Parameter" persistable="0" isFixedValue="0" dim="Dose per body surface area" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0" displayUnit="mg/m²">
+                            <Info min="0" flag="50" seq="2" ref="0" bb="2" group="88" />
+                          </Parameter>
+                          <Parameter id="Nh4oIn1ng0KWXx2Eo6ysyw" name="DosePerBodyWeight" description="Dose" icon="Parameter" persistable="0" isFixedValue="0" dim="Dose per body weight" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1E-06" displayUnit="mg/kg">
+                            <Info min="0" flag="58" seq="2" ref="0" bb="16" group="88" />
+                          </Parameter>
+                          <Parameter id="K3edaAjWNUK8rb1jgDh-pw" name="DrugMass" description="Drug mass of application" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" formula="AVY7rVJpJUC5GdqAokaEuQ" isDefault="1" displayUnit="µmol">
+                            <Tags>
+                              <Tag value="MOLECULE" />
+                            </Tags>
+                            <Info min="0" flag="54" seq="2" ref="0" bb="2" group="88" />
+                          </Parameter>
+                        </Children>
+                      </Container>
+                      <ApplicationMoleculeBuilder id="8PRIbkTlIEGo7-4X7sufhw" name="Application_3" formula="kJrzl2mJKEmGqQwjxmeb5A">
+                        <RelativeContainerPath path="3" />
+                      </ApplicationMoleculeBuilder>
+                    </Children>
+                    <SourceCriteria>
+                      <DescriptorConditions>
+                        <MatchTagCondition tag="Applications" />
+                      </DescriptorConditions>
+                    </SourceCriteria>
+                  </ApplicationBuilder>
+                </Children>
+                <SourceCriteria />
+              </EventGroupBuilder>
+            </Children>
+            <SourceCriteria>
+              <DescriptorConditions>
+                <MatchTagCondition tag="RootContainer" />
+              </DescriptorConditions>
+            </SourceCriteria>
+          </EventGroupBuilder>
+        </Builders>
+        <FormulaCache>
+          <Formulas>
+            <Formula id="i8Wmc7y-n0SEIJc480xgVQ" name="IV_Bolus" dim="Amount" formula="M + DrugMass">
+              <Paths>
+                <Path path="0" as="4" dim="5" />
+                <Path path="6" as="7" dim="5" />
+              </Paths>
+            </Formula>
+            <Formula id="0scNpznCS0OoY_njzeldxw" name="AppStartEventCondition" formula="Time=StartTime">
+              <Paths>
+                <Path path="8" as="9" dim="10" />
+                <TimePath />
+              </Paths>
+            </Formula>
+            <Formula id="AVY7rVJpJUC5GdqAokaEuQ" name="PARAM_Application_DrugMass" dim="Amount" formula="Dose / MW">
+              <Paths>
+                <Path path="11" as="12" dim="13" />
+                <Path path="14" as="15" dim="16" />
+              </Paths>
+            </Formula>
+            <Formula id="W2ddM-j8iUS3oQLMWCjqag" name="PARAM_Application_DoseFromDosePerBodyWeight" dim="Mass" formula="DosePerBodyWeight * BW">
+              <Paths>
+                <Path path="17" as="18" dim="19" />
+                <Path path="20" as="21" dim="13" />
+              </Paths>
+            </Formula>
+            <Formula id="kJrzl2mJKEmGqQwjxmeb5A" name="DrugMass" dim="Amount" formula="DrugMass">
+              <Paths>
+                <Path path="22" as="7" dim="5" />
+              </Paths>
+            </Formula>
+          </Formulas>
+          <StringMap>
+            <Map s="Organism|VenousBlood|Plasma|MOLECULE" id="0" />
+            <Map s="..|Application_1" id="1" />
+            <Map s="..|Application_2" id="2" />
+            <Map s="..|Application_3" id="3" />
+            <Map s="M" id="4" />
+            <Map s="Amount" id="5" />
+            <Map s="..|..|ProtocolSchemaItem|DrugMass" id="6" />
+            <Map s="DrugMass" id="7" />
+            <Map s="..|ProtocolSchemaItem|Start time" id="8" />
+            <Map s="StartTime" id="9" />
+            <Map s="Time" id="10" />
+            <Map s="..|Dose" id="11" />
+            <Map s="Dose" id="12" />
+            <Map s="Mass" id="13" />
+            <Map s="MOLECULE|Molecular weight" id="14" />
+            <Map s="MW" id="15" />
+            <Map s="Molecular weight" id="16" />
+            <Map s="..|DosePerBodyWeight" id="17" />
+            <Map s="DosePerBodyWeight" id="18" />
+            <Map s="Dose per body weight" id="19" />
+            <Map s="Organism|Weight" id="20" />
+            <Map s="BW" id="21" />
+            <Map s="..|ProtocolSchemaItem|DrugMass" id="22" />
+          </StringMap>
+        </FormulaCache>
+      </EventGroups>
+      <PassiveTransports id="ATtrK0RD_Ua7dbOyp57Oxw" name="Sim" icon="PassiveTransport" bbVersion="0">
+        <Creation createdAt="5248777815990455205" createdBy="Michael" creationMode="New" origin="PKSim" version="9.0" internalVersion="77" />
+        <Builders>
+          <TransportBuilder id="45W5gi83oUGm8-NRWYg_jw" name="DrugAbsorption_para" description="Drug absorption paracellular" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="1" processRateParameterPersistable="0" formula="88ZRy5SWw0SBFdOmWtL3Rg" transportType="0">
+            <SourceCriteria>
+              <DescriptorConditions>
+                <MatchTagCondition tag="Lumen" />
+              </DescriptorConditions>
+            </SourceCriteria>
+            <TargetCriteria>
+              <DescriptorConditions>
+                <MatchTagCondition tag="Mucosa" />
+                <MatchTagCondition tag="Plasma" />
+                <MatchTagCondition tag="SmallIntestineSegment" />
+              </DescriptorConditions>
+            </TargetCriteria>
+            <MoleculeList forAll="1" />
+          </TransportBuilder>
+          <TransportBuilder id="7yycelMu8km72KMFVjF6dw" name="DrugAbsorption_trans" description="Drug absorption transcellular" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="1" processRateParameterPersistable="0" formula="jE8fIYdGD0mjRRyS9S_bpA" transportType="0">
+            <SourceCriteria>
+              <DescriptorConditions>
+                <NotMatchTagCondition tag="Feces" />
+                <MatchTagCondition tag="Lumen" />
+              </DescriptorConditions>
+            </SourceCriteria>
+            <TargetCriteria>
+              <DescriptorConditions>
+                <MatchTagCondition tag="Intracellular" />
+                <MatchTagCondition tag="Mucosa" />
+              </DescriptorConditions>
+            </TargetCriteria>
+            <MoleculeList forAll="1" />
+          </TransportBuilder>
+          <TransportBuilder id="_JEk8DdtBk2sykrYqEEQuA" name="LumenDrugTransport_cae" description="Lumen drug transport from Lower Ileum to Cecum" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="JdqP5Vma-kOOum7hPlK_wA" transportType="0">
+            <SourceCriteria>
+              <DescriptorConditions>
+                <MatchTagCondition tag="LowerIleum" />
+                <MatchTagCondition tag="Lumen" />
+              </DescriptorConditions>
+            </SourceCriteria>
+            <TargetCriteria>
+              <DescriptorConditions>
+                <MatchTagCondition tag="Caecum" />
+                <MatchTagCondition tag="Lumen" />
+              </DescriptorConditions>
+            </TargetCriteria>
+            <MoleculeList forAll="1" />
+          </TransportBuilder>
+          <TransportBuilder id="kbIxFtaOuEuuPB2VE23WpQ" name="LumenDrugTransport_colasc" description="Lumen drug transport from Cecum to Colon Ascendens" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="JdqP5Vma-kOOum7hPlK_wA" transportType="0">
+            <SourceCriteria>
+              <DescriptorConditions>
+                <MatchTagCondition tag="Caecum" />
+                <MatchTagCondition tag="Lumen" />
+              </DescriptorConditions>
+            </SourceCriteria>
+            <TargetCriteria>
+              <DescriptorConditions>
+                <MatchTagCondition tag="ColonAscendens" />
+                <MatchTagCondition tag="Lumen" />
+              </DescriptorConditions>
+            </TargetCriteria>
+            <MoleculeList forAll="1" />
+          </TransportBuilder>
+          <TransportBuilder id="u9T0JXKZe066en2VH5b67A" name="LumenDrugTransport_coldesc" description="Lumen drug transport from Colon Transversum to Colon Descendens" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="JdqP5Vma-kOOum7hPlK_wA" transportType="0">
+            <SourceCriteria>
+              <DescriptorConditions>
+                <MatchTagCondition tag="ColonTransversum" />
+                <MatchTagCondition tag="Lumen" />
+              </DescriptorConditions>
+            </SourceCriteria>
+            <TargetCriteria>
+              <DescriptorConditions>
+                <MatchTagCondition tag="ColonDescendens" />
+                <MatchTagCondition tag="Lumen" />
+              </DescriptorConditions>
+            </TargetCriteria>
+            <MoleculeList forAll="1" />
+          </TransportBuilder>
+          <TransportBuilder id="_BETcxrtmkCRJYqq_kSLCA" name="LumenDrugTransport_colsigm" description="Lumen drug transport from Colon Descendens to Colon Sigmoid" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="JdqP5Vma-kOOum7hPlK_wA" transportType="0">
+            <SourceCriteria>
+              <DescriptorConditions>
+                <MatchTagCondition tag="ColonDescendens" />
+                <MatchTagCondition tag="Lumen" />
+              </DescriptorConditions>
+            </SourceCriteria>
+            <TargetCriteria>
+              <DescriptorConditions>
+                <MatchTagCondition tag="ColonSigmoid" />
+                <MatchTagCondition tag="Lumen" />
+              </DescriptorConditions>
+            </TargetCriteria>
+            <MoleculeList forAll="1" />
+          </TransportBuilder>
+          <TransportBuilder id="qjTORZITq0aGGZGhKsZcbQ" name="LumenDrugTransport_coltrans" description="Lumen drug transport from Colon Ascendens to Colon Transversum" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="JdqP5Vma-kOOum7hPlK_wA" transportType="0">
+            <SourceCriteria>
+              <DescriptorConditions>
+                <MatchTagCondition tag="ColonAscendens" />
+                <MatchTagCondition tag="Lumen" />
+              </DescriptorConditions>
+            </SourceCriteria>
+            <TargetCriteria>
+              <DescriptorConditions>
+                <MatchTagCondition tag="ColonTransversum" />
+                <MatchTagCondition tag="Lumen" />
+              </DescriptorConditions>
+            </TargetCriteria>
+            <MoleculeList forAll="1" />
+          </TransportBuilder>
+          <TransportBuilder id="zjsnBGRtrU2BaTxAIzeJbA" name="LumenDrugTransport_duo" description="Lumen drug transport from Stomach to Duodenum" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="JdqP5Vma-kOOum7hPlK_wA" transportType="0">
+            <SourceCriteria>
+              <DescriptorConditions>
+                <MatchTagCondition tag="Lumen" />
+                <MatchTagCondition tag="Stomach" />
+              </DescriptorConditions>
+            </SourceCriteria>
+            <TargetCriteria>
+              <DescriptorConditions>
+                <MatchTagCondition tag="Duodenum" />
+                <MatchTagCondition tag="Lumen" />
+              </DescriptorConditions>
+            </TargetCriteria>
+            <MoleculeList forAll="1" />
+          </TransportBuilder>
+          <TransportBuilder id="__ME3Q7fmEu7RYSnQJPj4g" name="LumenDrugTransport_fec" description="Lumen drug transport from Rectum to Feces" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="MEZhdyqX30GaPiBvYMPnbg" transportType="0">
+            <SourceCriteria>
+              <DescriptorConditions>
+                <MatchTagCondition tag="Lumen" />
+                <MatchTagCondition tag="Rectum" />
+              </DescriptorConditions>
+            </SourceCriteria>
+            <TargetCriteria>
+              <DescriptorConditions>
+                <MatchTagCondition tag="Feces" />
+                <MatchTagCondition tag="Lumen" />
+              </DescriptorConditions>
+            </TargetCriteria>
+            <MoleculeList forAll="1" />
+          </TransportBuilder>
+          <TransportBuilder id="C84HSsrKFUaMde65R-9ooA" name="LumenDrugTransport_lil" description="Lumen drug transport from Upper Ileum to Lower Ileum" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="JdqP5Vma-kOOum7hPlK_wA" transportType="0">
+            <SourceCriteria>
+              <DescriptorConditions>
+                <MatchTagCondition tag="Lumen" />
+                <MatchTagCondition tag="UpperIleum" />
+              </DescriptorConditions>
+            </SourceCriteria>
+            <TargetCriteria>
+              <DescriptorConditions>
+                <MatchTagCondition tag="LowerIleum" />
+                <MatchTagCondition tag="Lumen" />
+              </DescriptorConditions>
+            </TargetCriteria>
+            <MoleculeList forAll="1" />
+          </TransportBuilder>
+          <TransportBuilder id="vM3NZhoVOUaz1_l-R9SqoQ" name="LumenDrugTransport_lje" description="Lumen drug transport from Upper Jejunum to Lower Jejunum" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="JdqP5Vma-kOOum7hPlK_wA" transportType="0">
+            <SourceCriteria>
+              <DescriptorConditions>
+                <MatchTagCondition tag="Lumen" />
+                <MatchTagCondition tag="UpperJejunum" />
+              </DescriptorConditions>
+            </SourceCriteria>
+            <TargetCriteria>
+              <DescriptorConditions>
+                <MatchTagCondition tag="LowerJejunum" />
+                <MatchTagCondition tag="Lumen" />
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+            <MoleculeList forAll="1" />
+          </TransportBuilder>
+          <TransportBuilder id="8mYnkhyqxUCr6cmhK06i7w" name="LumenDrugTransport_rect" description="Lumen drug transport from Colon Sigmoid to Rectum" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="JdqP5Vma-kOOum7hPlK_wA" transportType="0">
+            <SourceCriteria>
+              <DescriptorConditions>
+                <MatchTagCondition tag="ColonSigmoid" />
+                <MatchTagCondition tag="Lumen" />
+              </DescriptorConditions>
+            </SourceCriteria>
+            <TargetCriteria>
+              <DescriptorConditions>
+                <MatchTagCondition tag="Lumen" />
+                <MatchTagCondition tag="Rectum" />
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+            </TargetCriteria>
+            <MoleculeList forAll="1" />
+          </TransportBuilder>
+          <TransportBuilder id="QD6rC3A3YEqVZeo7lU0zPA" name="LumenDrugTransport_uil" description="Lumen drug transport from Lower Jejunum to Upper Ileum" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="JdqP5Vma-kOOum7hPlK_wA" transportType="0">
+            <SourceCriteria>
+              <DescriptorConditions>
+                <MatchTagCondition tag="LowerJejunum" />
+                <MatchTagCondition tag="Lumen" />
+              </DescriptorConditions>
+            </SourceCriteria>
+            <TargetCriteria>
+              <DescriptorConditions>
+                <MatchTagCondition tag="Lumen" />
+                <MatchTagCondition tag="UpperIleum" />
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+            </TargetCriteria>
+            <MoleculeList forAll="1" />
+          </TransportBuilder>
+          <TransportBuilder id="S7G-Lo4Te0WIiNEyiicUPA" name="LumenDrugTransport_uje" description="Lumen drug transport from Duodenum to Upper Jejunum" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="JdqP5Vma-kOOum7hPlK_wA" transportType="0">
+            <SourceCriteria>
+              <DescriptorConditions>
+                <MatchTagCondition tag="Duodenum" />
+                <MatchTagCondition tag="Lumen" />
+              </DescriptorConditions>
+            </SourceCriteria>
+            <TargetCriteria>
+              <DescriptorConditions>
+                <MatchTagCondition tag="Lumen" />
+                <MatchTagCondition tag="UpperJejunum" />
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+            </TargetCriteria>
+            <MoleculeList forAll="1" />
+          </TransportBuilder>
+          <TransportBuilder id="bgIzuv3j50SJHy1PtEH1lA" name="MassTransferBloodPool2OrgPl" description="Mass transfer from Arterial Blood: Plasma to organ: Plasma" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="cS4azwgPRUKwC0VtiF-dSg" transportType="0">
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+                <MatchTagCondition tag="ArterialBlood" />
+                <MatchTagCondition tag="Plasma" />
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+              <DescriptorConditions>
+                <NotMatchTagCondition tag="ArterialBlood" />
+                <NotMatchTagCondition tag="Lung" />
+                <MatchTagCondition tag="Plasma" />
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+            <MoleculeList forAll="1" />
+          </TransportBuilder>
+          <TransportBuilder id="xTOD7bTPrE6DW5PCBkSYlQ" name="MassTransferBloodPool2OrgPl_liv" description="Mass transfer from Portal Vein: Plasma to Liver: Plasma" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="RsfLdh46R0eIhzQTyo5nVQ" transportType="0">
+            <SourceCriteria>
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+                <MatchTagCondition tag="Plasma" />
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+              <DescriptorConditions>
+                <MatchTagCondition tag="Liver" />
+                <MatchTagCondition tag="Plasma" />
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+            <MoleculeList forAll="1" />
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+          <TransportBuilder id="CuA1zj37NkqNXkNfw1GHGw" name="MassTransferBloodPool2OrgPl_lng" description="Mass transfer from Venous Blood: Plasma to Lung: Plasma" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="a7-0ODzyDUa-BNwsXs9JYA" transportType="0">
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+                <MatchTagCondition tag="Plasma" />
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+              <DescriptorConditions>
+                <MatchTagCondition tag="Lung" />
+                <MatchTagCondition tag="Plasma" />
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+            <MoleculeList forAll="1" />
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+          <TransportBuilder id="chI39068ak2635fRUlYnqA" name="MassTransferBloodPool2OrgRBC" description="Mass transfer from ArterialBlood: BloodCells to organ: Blood Cells" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="L_JGRrwF8k62zErcePHbHg" transportType="0">
+            <SourceCriteria>
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+                <MatchTagCondition tag="ArterialBlood" />
+                <MatchTagCondition tag="BloodCells" />
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+              <DescriptorConditions>
+                <NotMatchTagCondition tag="ArterialBlood" />
+                <MatchTagCondition tag="BloodCells" />
+                <NotMatchTagCondition tag="Lung" />
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+            <MoleculeList forAll="1" />
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+          <TransportBuilder id="kGrFvkCpaEmtSweZkA3rVA" name="MassTransferBloodPool2OrgRBC_liv" description="Mass transfer from Portal Vein: Blood Cells to Liver: Blood Cells" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="Nvo4GK7fkEG_USbiqIdRxw" transportType="0">
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+                <MatchTagCondition tag="BloodCells" />
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+                <MatchTagCondition tag="BloodCells" />
+                <MatchTagCondition tag="Liver" />
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+            <MoleculeList forAll="1" />
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+          <TransportBuilder id="LD5cBoJDLkuPWvVG-ATLaQ" name="MassTransferBloodPool2OrgRBC_lng" description="Mass transfer from Venous Blood: Blood Cells to Lung: Blood Cells" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="4MSixQ-jIUa1illV8BvEVg" transportType="0">
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+                <MatchTagCondition tag="BloodCells" />
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+                <MatchTagCondition tag="BloodCells" />
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+            <MoleculeList forAll="1" />
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+          <TransportBuilder id="IZB3gHtatESi_GE3SBnhzg" name="MassTransferLINToMucosaBC" description="Mass transfer from Large Intestine:Blood Cells to Mucosa: Blood Cells" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="VPdkrlLNokqlgnYpcUX3hQ" transportType="0">
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+                <MatchTagCondition tag="BloodCells" />
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+                <MatchTagCondition tag="BloodCells" />
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+            <MoleculeList forAll="1" />
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+          <TransportBuilder id="MwjZBUgQu0aUH8coYl55QA" name="MassTransferLINToMucosaPlasma" description="Mass transfer from Large Intestine:Plasma to Mucosa: Plasma" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="SxZwmpRb5UGQfu5vnxM_-A" transportType="0">
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+                <MatchTagCondition tag="LargeIntestine" />
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+                <MatchTagCondition tag="Mucosa" />
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+            <MoleculeList forAll="1" />
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+          <TransportBuilder id="FC9TYYJLbkCXyPd9RFjuaQ" name="MassTransferLinPlasma2BloodPool_Pve" description="Mass transfer from Large Intestine :Plasma to Portal Vein: Plasma" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="bKuYFCRyAkGaH7pE343lrQ" transportType="0">
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+                <MatchTagCondition tag="LargeIntestine" />
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+                <MatchTagCondition tag="Plasma" />
+                <MatchTagCondition tag="PortalVein" />
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+            <MoleculeList forAll="1" />
+          </TransportBuilder>
+          <TransportBuilder id="ZFXa3pLl3k6SyZiPAkHDvA" name="MassTransferLinRBC2BloodPool_Pve" description="Mass transfer from Large Intestine to Portal Vein: Blood Cells" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="7I1q68N8sk-2MlNkTsMozQ" transportType="0">
+            <SourceCriteria>
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+                <MatchTagCondition tag="BloodCells" />
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+                <MatchTagCondition tag="BloodCells" />
+                <MatchTagCondition tag="PortalVein" />
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+            <MoleculeList forAll="1" />
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+          <TransportBuilder id="ORUzgyYOW0OO2YD_ZzBRRw" name="MassTransferMucosaToPveBC" description="Mass transfer from Mucosa:Blood Cells To Portal Vein: Blood Cells" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="Nk770XCSJ0-7cYvCA_7hKw" transportType="0">
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+                <MatchTagCondition tag="BloodCells" />
+                <MatchTagCondition tag="Mucosa" />
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+                <MatchTagCondition tag="BloodCells" />
+                <MatchTagCondition tag="PortalVein" />
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+            <MoleculeList forAll="1" />
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+          <TransportBuilder id="k62Tq5sqkU-9fd7_i47Ncg" name="MassTransferMucosaToPvePlasma" description="Mass transfer from Mucosa:Plasma To Portal Vein: Plasma" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="2qsII7lJNkGKbw3s61wMlQ" transportType="0">
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+                <MatchTagCondition tag="Plasma" />
+                <MatchTagCondition tag="PortalVein" />
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+            <MoleculeList forAll="1" />
+          </TransportBuilder>
+          <TransportBuilder id="eAfDbH42nUG3KCo-Ts8VMg" name="MassTransferOrgPl2BloodPool" description="Mass transfer from organ: Plasma to Venous Blood: Plasma" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="nqSWnflPhkKI99-nxHeXBQ" transportType="0">
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+                <NotMatchTagCondition tag="Liver" />
+                <NotMatchTagCondition tag="Lung" />
+                <MatchTagCondition tag="Plasma" />
+                <NotMatchTagCondition tag="VenousBlood" />
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+                <MatchTagCondition tag="Plasma" />
+                <MatchTagCondition tag="VenousBlood" />
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+            <MoleculeList forAll="1" />
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+          <TransportBuilder id="kdCUCCqVik6oklw9wHI6DA" name="MassTransferOrgPl2BloodPool_Liv" description="Mass transfer from Liver: Plasma to Venous Blood: Plasma" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="qYjpLcgd6UWbowvB-zAMVA" transportType="0">
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+                <MatchTagCondition tag="Liver" />
+                <MatchTagCondition tag="Periportal" />
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+                <MatchTagCondition tag="Plasma" />
+                <MatchTagCondition tag="VenousBlood" />
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+            <MoleculeList forAll="1" />
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+          <TransportBuilder id="eZccCN2vWUCh06qBCyLZdA" name="MassTransferOrgPl2BloodPool_Liv_Pericentral" description="Mass transfer from Liver: Plasma to Venous Blood: Plasma" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="j0hdqmJ9o0a5ANe1tD3jsg" transportType="0">
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+                <MatchTagCondition tag="Plasma" />
+                <MatchTagCondition tag="VenousBlood" />
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+            <MoleculeList forAll="1" />
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+          <TransportBuilder id="dLMTJ4oMPEyWHVeJVB5l8w" name="MassTransferOrgPl2BloodPool_Lng" description="Mass transfer from Lung: Plasma to Arterial Blood: Plasma" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="c6ZwMLWIt0az-96lePEWZw" transportType="0">
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+                <MatchTagCondition tag="Lung" />
+                <MatchTagCondition tag="Plasma" />
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+              <DescriptorConditions>
+                <MatchTagCondition tag="ArterialBlood" />
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+            <MoleculeList forAll="1" />
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+          <TransportBuilder id="kqzS97GtpUukUpmN46r1-g" name="MassTransferOrgPl2BloodPool_pve" description="Mass transfer from organ: Plasma to Portal Vein: Plasma" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="uZUi6PgLuEqSdRX_j_BsQA" transportType="0">
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+                <NotMatchTagCondition tag="LargeIntestine" />
+                <NotMatchTagCondition tag="Mucosa" />
+                <MatchTagCondition tag="Plasma" />
+                <MatchTagCondition tag="Portal Vein Supplying Organ" />
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+                <MatchTagCondition tag="Plasma" />
+                <MatchTagCondition tag="PortalVein" />
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+            <MoleculeList forAll="1" />
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+          <TransportBuilder id="pu9qasyXJkmQXVd1-ChShg" name="MassTransferOrgRBC2BloodPool" description="Mass transfer from organ: Blood Cells to Arterial Blood: Blood Cells" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="dSsfj-UFPEqh3Uj-Xpf9HA" transportType="0">
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+                <MatchTagCondition tag="BloodCells" />
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+                <NotMatchTagCondition tag="VenousBlood" />
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+                <MatchTagCondition tag="BloodCells" />
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+            <MoleculeList forAll="1" />
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+          <TransportBuilder id="5n10Zcwtzku9PGqM3gxc3A" name="MassTransferOrgRBC2BloodPool_Liv" description="Mass transfer from Liver: Blood Cells to Venous Blood: Blood Cells" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="--368xuQmEWOnbb9rVypCA" transportType="0">
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+                <MatchTagCondition tag="BloodCells" />
+                <MatchTagCondition tag="Liver" />
+                <MatchTagCondition tag="Periportal" />
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+                <MatchTagCondition tag="BloodCells" />
+                <MatchTagCondition tag="VenousBlood" />
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+            <MoleculeList forAll="1" />
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+          <TransportBuilder id="dG8MJF3-qEawhDuMlh3MVg" name="MassTransferOrgRBC2BloodPool_Liv_Pericentral" description="Mass transfer from Liver: Blood Cells to Venous Blood: Blood Cells" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="VgYkBLMH60ahAgHZtE2Yig" transportType="0">
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+                <MatchTagCondition tag="BloodCells" />
+                <MatchTagCondition tag="Liver" />
+                <MatchTagCondition tag="Pericentral" />
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+                <MatchTagCondition tag="BloodCells" />
+                <MatchTagCondition tag="VenousBlood" />
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+            <MoleculeList forAll="1" />
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+          <TransportBuilder id="2_pzU3tX8kGiK1gOx17C_Q" name="MassTransferOrgRBC2BloodPool_Lng" description="Mass transfer from Lung: Blood Cells to Arterial Blood: Blood Cells" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="8VMALS0HgkOkQoArzhUARg" transportType="0">
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+                <MatchTagCondition tag="BloodCells" />
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+                <MatchTagCondition tag="ArterialBlood" />
+                <MatchTagCondition tag="BloodCells" />
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+            <MoleculeList forAll="1" />
+          </TransportBuilder>
+          <TransportBuilder id="3dUDhrylek-UCpsG9gx81w" name="MassTransferOrgRBC2BloodPool_Pve" description="Mass transfer from organ: Blood Cells to Portal Vein: Blood Cells" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="Usd-3O_bSUC6ar99fPV-8Q" transportType="0">
+            <SourceCriteria>
+              <DescriptorConditions>
+                <MatchTagCondition tag="BloodCells" />
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+                <NotMatchTagCondition tag="Liver" />
+                <NotMatchTagCondition tag="Mucosa" />
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+              <DescriptorConditions>
+                <MatchTagCondition tag="BloodCells" />
+                <MatchTagCondition tag="PortalVein" />
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+            <MoleculeList forAll="1" />
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+          <TransportBuilder id="8B4wMDhcqEyneQtzq5J7Ew" name="MassTransferSINToMucosaBC" description="Mass transfer from Small Intestine:Blood Cells to Mucosa: Blood Cells" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="VPdkrlLNokqlgnYpcUX3hQ" transportType="0">
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+                <MatchTagCondition tag="BloodCells" />
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+                <MatchTagCondition tag="SmallIntestine" />
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+              <DescriptorConditions>
+                <MatchTagCondition tag="BloodCells" />
+                <MatchTagCondition tag="Mucosa" />
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+            <MoleculeList forAll="1" />
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+          <TransportBuilder id="jsl3Wr4PxkSTyYZj_AvlfA" name="MassTransferSINToMucosaPlasma" description="Mass transfer from Small Intestine:Plasma to Mucosa: Plasma" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="SxZwmpRb5UGQfu5vnxM_-A" transportType="0">
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+                <NotMatchTagCondition tag="Mucosa" />
+                <MatchTagCondition tag="Plasma" />
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+                <MatchTagCondition tag="Mucosa" />
+                <MatchTagCondition tag="Plasma" />
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+            <MoleculeList forAll="1" />
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+          <TransportBuilder id="BPP0PpI89EKqkdz2yX1_YA" name="MassTransferSinPlasma2BloodPool_Pve" description="Mass transfer from Small Intestine:Plasma to Portal Vein: Plasma" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="bKuYFCRyAkGaH7pE343lrQ" transportType="0">
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+                <NotMatchTagCondition tag="Mucosa" />
+                <MatchTagCondition tag="Plasma" />
+                <MatchTagCondition tag="SmallIntestine" />
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+              <DescriptorConditions>
+                <MatchTagCondition tag="Plasma" />
+                <MatchTagCondition tag="PortalVein" />
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+            <MoleculeList forAll="1" />
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+          <TransportBuilder id="CNaqy6vh7kqE5w-NKzIWbw" name="MassTransferSinRBC2BloodPool_Pve" description="Mass transfer from Small Intestine:Blood Cells to Portal Vein: Blood Cells" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="7I1q68N8sk-2MlNkTsMozQ" transportType="0">
+            <SourceCriteria>
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+                <MatchTagCondition tag="BloodCells" />
+                <NotMatchTagCondition tag="Mucosa" />
+                <MatchTagCondition tag="SmallIntestine" />
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+              <DescriptorConditions>
+                <MatchTagCondition tag="BloodCells" />
+                <MatchTagCondition tag="PortalVein" />
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+            <MoleculeList forAll="1" />
+          </TransportBuilder>
+          <TransportBuilder id="AWF0v_u5PUi7dBS4UkHhbA" name="MassTransfer_PeriportalToPericentral_BC" description="Mass transfer from Liver Periportal Blood Cells to Liver Pericentral Blood Cells" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="uqosaOCTo0W4_E7eV3QQvA" transportType="0">
+            <SourceCriteria>
+              <DescriptorConditions>
+                <MatchTagCondition tag="BloodCells" />
+                <MatchTagCondition tag="Liver" />
+                <MatchTagCondition tag="Periportal" />
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+              <DescriptorConditions>
+                <MatchTagCondition tag="BloodCells" />
+                <MatchTagCondition tag="Liver" />
+                <MatchTagCondition tag="Pericentral" />
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+            <MoleculeList forAll="1" />
+          </TransportBuilder>
+          <TransportBuilder id="WRbGMGc10kyialWZawucbA" name="MassTransfer_PeriportalToPericentral_Plasma" description="Mass transfer from Liver Periportal Plasma to Liver Pericentral Plasma" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="fX8typMREUOF35_JsbJFhg" transportType="0">
+            <SourceCriteria>
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+                <MatchTagCondition tag="Liver" />
+                <MatchTagCondition tag="Periportal" />
+                <MatchTagCondition tag="Plasma" />
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+              <DescriptorConditions>
+                <MatchTagCondition tag="Liver" />
+                <MatchTagCondition tag="Pericentral" />
+                <MatchTagCondition tag="Plasma" />
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+            <MoleculeList forAll="1" />
+          </TransportBuilder>
+          <TransportBuilder id="Fyt8Dylk4kW5uruVtxLT_g" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="cZCrlbO_HEWB6HlpsgDUDQ" transportType="0">
+            <SourceCriteria>
+              <DescriptorConditions>
+                <MatchTagCondition tag="Interstitial" />
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+            <TargetCriteria>
+              <DescriptorConditions>
+                <MatchTagCondition tag="Intracellular" />
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+            <MoleculeList forAll="1" />
+          </TransportBuilder>
+          <TransportBuilder id="vh568OJHAkmJ2YZaiHgrvA" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="lRrweqoOPUSqOTC-13H2rg" transportType="0">
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+                <NotMatchTagCondition tag="ArterialBlood" />
+                <NotMatchTagCondition tag="Endogenous_IgG" />
+                <MatchTagCondition tag="Plasma" />
+                <NotMatchTagCondition tag="PortalVein" />
+                <NotMatchTagCondition tag="VenousBlood" />
+              </DescriptorConditions>
+            </SourceCriteria>
+            <TargetCriteria>
+              <DescriptorConditions>
+                <MatchTagCondition tag="Interstitial" />
+              </DescriptorConditions>
+            </TargetCriteria>
+            <MoleculeList forAll="1" />
+          </TransportBuilder>
+          <TransportBuilder id="fXO-6PduMka0qCFrYVCwsw" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="39G8faBkBkWULPnnMTY0Vw" transportType="0">
+            <SourceCriteria>
+              <DescriptorConditions>
+                <MatchTagCondition tag="Plasma" />
+              </DescriptorConditions>
+            </SourceCriteria>
+            <TargetCriteria>
+              <DescriptorConditions>
+                <MatchTagCondition tag="BloodCells" />
+              </DescriptorConditions>
+            </TargetCriteria>
+            <MoleculeList forAll="1" />
+          </TransportBuilder>
+          <TransportBuilder id="EgNaBTrNbkmj8knHEhOWog" name="PassiveDiffusionPlsToSaliva" description="Passive diffusion plasma to saliva" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="npHnQFEa102RT9WkcZFwaw" transportType="0">
+            <SourceCriteria>
+              <DescriptorConditions>
+                <MatchTagCondition tag="Saliva" />
+                <MatchTagCondition tag="SalivaGland" />
+              </DescriptorConditions>
+            </SourceCriteria>
+            <TargetCriteria>
+              <DescriptorConditions>
+                <MatchTagCondition tag="Saliva" />
+                <NotMatchTagCondition tag="SalivaGland" />
+              </DescriptorConditions>
+            </TargetCriteria>
+            <MoleculeList forAll="1" />
+          </TransportBuilder>
+          <TransportBuilder id="AfNkXRTLLkWx2VWj_qbGIg" name="GallbladderEmptying" description="Gallbladder emptying" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="BV_8avpnEUOv3WxvgZi-9w" transportType="0">
+            <SourceCriteria>
+              <DescriptorConditions>
+                <MatchTagCondition tag="Gallbladder" />
+              </DescriptorConditions>
+            </SourceCriteria>
+            <TargetCriteria>
+              <DescriptorConditions>
+                <MatchTagCondition tag="Duodenum" />
+                <MatchTagCondition tag="Lumen" />
+              </DescriptorConditions>
+            </TargetCriteria>
+            <MoleculeList forAll="1" />
+          </TransportBuilder>
+          <TransportBuilder id="Ju97GykVz06ZqLeYaiXCzA" name="Renal Clearances-TS" icon="TubularSecretion" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="QzAJ32zZ_UOKH_H2R6jv8Q" transportType="0">
+            <Children>
+              <Parameter id="I0pFWHf02kC87hRTBCBQMg" name="Volume (kidney)" description="Volume of the kidney" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="0" value="0.4377199853" displayUnit="l">
+                <ValueOrigin source="Unknown" />
+                <Info min="0" flag="58" seq="1" ref="0" bb="4" group="130" />
+              </Parameter>
+              <Parameter id="M8PAuGiA6kqhSrQn0OAJlw" name="Tubular secretion" description="Intrinsic clearance for tubular secretion" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" isDefault="0" value="0.412" displayUnit="l/min">
+                <Info min="0" flag="58" seq="2" ref="0" bb="4" group="130" />
+              </Parameter>
+              <Parameter id="Qk6K-vFu70mMQazgKkTFvg" name="TSspec" description="Specific clearance for tubular secretion" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="uj7hx8HRlUiFH1IYq04UMQ" isDefault="1" displayUnit="1/min">
+                <Info min="0" flag="122" seq="3" ref="0" bb="4" group="131" />
+              </Parameter>
+            </Children>
+            <SourceCriteria>
+              <DescriptorConditions>
+                <MatchTagCondition tag="Kidney" />
+                <MatchTagCondition tag="Plasma" />
+              </DescriptorConditions>
+            </SourceCriteria>
+            <TargetCriteria>
+              <DescriptorConditions>
+                <MatchTagCondition tag="Kidney" />
+                <MatchTagCondition tag="Urine" />
+              </DescriptorConditions>
+            </TargetCriteria>
+            <MoleculeList forAll="0">
+              <MoleculeNames>
+                <MoleculeNamesChild>Aciclovir</MoleculeNamesChild>
+              </MoleculeNames>
+            </MoleculeList>
+          </TransportBuilder>
+          <TransportBuilder id="6_iS5_MDvU2NIxfy1KTBUQ" name="Glomerular Filtration-GFR" icon="GlomerularFiltration" mode="Logical" containerType="Other" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="icYTNLU4wU60MDsnKTVvnw" transportType="0">
+            <Children>
+              <Parameter id="JBTh-VmOYEuUrawg4wmylA" name="GFR fraction" description="Fraction of glomerular filtration rate used for passive renal elimination.&#xD;&#xA;GFR fraction should be reduced in the case of:&#xD;&#xA;* actively reabsorbed molecules&#xD;&#xA;* macromolecules" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="0" value="1">
+                <Info min="0" flag="122" seq="1" ref="0" bb="4" group="131" />
+              </Parameter>
+            </Children>
+            <SourceCriteria>
+              <DescriptorConditions>
+                <MatchTagCondition tag="Kidney" />
+                <MatchTagCondition tag="Plasma" />
+              </DescriptorConditions>
+            </SourceCriteria>
+            <TargetCriteria>
+              <DescriptorConditions>
+                <MatchTagCondition tag="Kidney" />
+                <MatchTagCondition tag="Urine" />
+              </DescriptorConditions>
+            </TargetCriteria>
+            <MoleculeList forAll="0">
+              <MoleculeNames>
+                <MoleculeNamesChild>Aciclovir</MoleculeNamesChild>
+              </MoleculeNames>
+            </MoleculeList>
+          </TransportBuilder>
+        </Builders>
+        <FormulaCache>
+          <Formulas>
+            <Formula id="88ZRy5SWw0SBFdOmWtL3Rg" name="DrugAbsorption_para" dim="Amount per time" formula="DrugAbsorptionLumenToMucosaRate">
+              <Paths>
+                <Path path="0" as="1" dim="2" />
+              </Paths>
+            </Formula>
+            <Formula id="jE8fIYdGD0mjRRyS9S_bpA" name="DrugAbsorption_trans" dim="Amount per time" formula="DrugAbsorptionLumenToMucosaRate">
+              <Paths>
+                <Path path="0" as="1" dim="2" />
+              </Paths>
+            </Formula>
+            <Formula id="JdqP5Vma-kOOum7hPlK_wA" name="LumenDrugTransport" dim="Amount per time" formula="(OralApplicationsEnabled AND IsFloatingInLumen) ? w*Drug*FillLevelFlagNext : 0">
+              <Paths>
+                <Path path="3" as="4" />
+                <Path path="5" as="6" dim="7" />
+                <Path path="8" as="9" />
+                <Path path="10" as="11" dim="12" />
+                <Path path="13" as="14" />
+              </Paths>
+            </Formula>
+            <Formula id="MEZhdyqX30GaPiBvYMPnbg" name="LumenDrugTransport_Feces" dim="Amount per time" formula="OralApplicationsEnabled ? w*Drug : 0">
+              <Paths>
+                <Path path="3" as="4" />
+                <Path path="5" as="6" dim="7" />
+                <Path path="10" as="11" dim="12" />
+              </Paths>
+            </Formula>
+            <Formula id="cS4azwgPRUKwC0VtiF-dSg" name="MassTransferBloodPool2OrgPl" dim="Amount per time" formula="Q*(1-HCT)*C_pls">
+              <Paths>
+                <Path path="15" as="16" dim="17" />
+                <Path path="18" as="19" dim="20" />
+                <Path path="21" as="22" />
+              </Paths>
+            </Formula>
+            <Formula id="RsfLdh46R0eIhzQTyo5nVQ" name="MassTransferBloodPool2OrgPl_liv" dim="Amount per time" formula="Q*(1-HCT)*C_pls">
+              <Paths>
+                <Path path="23" as="16" dim="17" />
+                <Path path="18" as="19" dim="20" />
+                <Path path="21" as="22" />
+              </Paths>
+            </Formula>
+            <Formula id="a7-0ODzyDUa-BNwsXs9JYA" name="MassTransferBloodPool2OrgPl_lng" dim="Amount per time" formula="Q*(1-HCT)*C_pls">
+              <Paths>
+                <Path path="15" as="16" dim="17" />
+                <Path path="18" as="19" dim="20" />
+                <Path path="21" as="22" />
+              </Paths>
+            </Formula>
+            <Formula id="L_JGRrwF8k62zErcePHbHg" name="MassTransferBloodPool2OrgRBC" dim="Amount per time" formula="Q*HCT*C_bc">
+              <Paths>
+                <Path path="15" as="16" dim="17" />
+                <Path path="18" as="24" dim="20" />
+                <Path path="21" as="22" />
+              </Paths>
+            </Formula>
+            <Formula id="Nvo4GK7fkEG_USbiqIdRxw" name="MassTransferBloodPool2OrgRBC_liv" dim="Amount per time" formula="Q*HCT*C_bc">
+              <Paths>
+                <Path path="23" as="16" dim="17" />
+                <Path path="18" as="24" dim="20" />
+                <Path path="21" as="22" />
+              </Paths>
+            </Formula>
+            <Formula id="4MSixQ-jIUa1illV8BvEVg" name="MassTransferBloodPool2OrgRBC_lng" dim="Amount per time" formula="Q*HCT*C_bc">
+              <Paths>
+                <Path path="15" as="16" dim="17" />
+                <Path path="18" as="24" dim="20" />
+                <Path path="21" as="22" />
+              </Paths>
+            </Formula>
+            <Formula id="VPdkrlLNokqlgnYpcUX3hQ" name="MassTransferIntestineToMucosaBC" dim="Amount per time" formula="MassTransferIntestineToMucosaBCRate">
+              <Paths>
+                <Path path="25" as="26" dim="2" />
+              </Paths>
+            </Formula>
+            <Formula id="SxZwmpRb5UGQfu5vnxM_-A" name="MassTransferIntestineToMucosaPlasma" dim="Amount per time" formula="MassTransferIntestineToMucosaPlasmaRate">
+              <Paths>
+                <Path path="27" as="28" dim="2" />
+              </Paths>
+            </Formula>
+            <Formula id="bKuYFCRyAkGaH7pE343lrQ" name="MassTransferSinLinPlasma2BloodPool_Pve" dim="Amount per time" formula="(1-fractQ)*Q*(1-HCT)*C">
+              <Paths>
+                <Path path="23" as="16" dim="17" />
+                <Path path="29" as="30" />
+                <Path path="18" as="31" dim="20" />
+                <Path path="21" as="22" />
+              </Paths>
+            </Formula>
+            <Formula id="7I1q68N8sk-2MlNkTsMozQ" name="MassTransferSinLinRBC2BloodPool_Pve" dim="Amount per time" formula="(1-fractQ)*Q*HCT*C">
+              <Paths>
+                <Path path="23" as="16" dim="17" />
+                <Path path="29" as="30" />
+                <Path path="18" as="31" dim="20" />
+                <Path path="21" as="22" />
+              </Paths>
+            </Formula>
+            <Formula id="Nk770XCSJ0-7cYvCA_7hKw" name="MassTransferMucosaToPveBC" dim="Amount per time" formula="MassTransferMucosaToPveBCRate">
+              <Paths>
+                <Path path="32" as="33" dim="2" />
+              </Paths>
+            </Formula>
+            <Formula id="2qsII7lJNkGKbw3s61wMlQ" name="MassTransferMucosaToPvePlasma" dim="Amount per time" formula="MassTransferMucosaToPvePlasmaRate">
+              <Paths>
+                <Path path="34" as="35" dim="2" />
+              </Paths>
+            </Formula>
+            <Formula id="nqSWnflPhkKI99-nxHeXBQ" name="MassTransferOrgPl2BloodPool" dim="Amount per time" formula="Q*(1-HCT)*C_pls">
+              <Paths>
+                <Path path="23" as="16" dim="17" />
+                <Path path="18" as="19" dim="20" />
+                <Path path="21" as="22" />
+              </Paths>
+            </Formula>
+            <Formula id="qYjpLcgd6UWbowvB-zAMVA" name="MassTransferOrgPl2BloodPool_Liv" dim="Amount per time" formula="IsLiverZonated ? 0 : (Q_liv +Q_pve)*(1-HCT)*C_pls">
+              <Paths>
+                <Path path="23" as="36" dim="17" />
+                <Path path="18" as="19" dim="20" />
+                <Path path="21" as="22" />
+                <Path path="37" as="38" />
+                <Path path="39" as="40" dim="17" />
+              </Paths>
+            </Formula>
+            <Formula id="j0hdqmJ9o0a5ANe1tD3jsg" name="MassTransferOrgPl2BloodPool_Liv_Pericentral" dim="Amount per time" formula="IsLiverZonated ? (Q_liv +Q_pve)*(1-HCT)*C_pls : 0">
+              <Paths>
+                <Path path="23" as="36" dim="17" />
+                <Path path="18" as="19" dim="20" />
+                <Path path="21" as="22" />
+                <Path path="37" as="38" />
+                <Path path="39" as="40" dim="17" />
+              </Paths>
+            </Formula>
+            <Formula id="c6ZwMLWIt0az-96lePEWZw" name="MassTransferOrgPl2BloodPool_Lng" dim="Amount per time" formula="Q*(1-HCT)*C_pls">
+              <Paths>
+                <Path path="23" as="16" dim="17" />
+                <Path path="18" as="19" dim="20" />
+                <Path path="21" as="22" />
+              </Paths>
+            </Formula>
+            <Formula id="uZUi6PgLuEqSdRX_j_BsQA" name="MassTransferOrgPl2BloodPool_pve" dim="Amount per time" formula="Q*(1-HCT)*C_pls">
+              <Paths>
+                <Path path="23" as="16" dim="17" />
+                <Path path="18" as="19" dim="20" />
+                <Path path="21" as="22" />
+              </Paths>
+            </Formula>
+            <Formula id="dSsfj-UFPEqh3Uj-Xpf9HA" name="MassTransferOrgRBC2BloodPool" dim="Amount per time" formula="Q*HCT*C_bc">
+              <Paths>
+                <Path path="23" as="16" dim="17" />
+                <Path path="18" as="24" dim="20" />
+                <Path path="21" as="22" />
+              </Paths>
+            </Formula>
+            <Formula id="--368xuQmEWOnbb9rVypCA" name="MassTransferOrgRBC2BloodPool_Liv" dim="Amount per time" formula="IsLiverZonated ? 0 : (Q_liv +Q_pve)*HCT*C_bc">
+              <Paths>
+                <Path path="23" as="36" dim="17" />
+                <Path path="18" as="24" dim="20" />
+                <Path path="21" as="22" />
+                <Path path="37" as="38" />
+                <Path path="39" as="40" dim="17" />
+              </Paths>
+            </Formula>
+            <Formula id="VgYkBLMH60ahAgHZtE2Yig" name="MassTransferOrgRBC2BloodPool_Liv_Pericentral" dim="Amount per time" formula="IsLiverZonated ? (Q_liv +Q_pve)*HCT*C_bc : 0">
+              <Paths>
+                <Path path="23" as="36" dim="17" />
+                <Path path="18" as="24" dim="20" />
+                <Path path="21" as="22" />
+                <Path path="37" as="38" />
+                <Path path="39" as="40" dim="17" />
+              </Paths>
+            </Formula>
+            <Formula id="8VMALS0HgkOkQoArzhUARg" name="MassTransferOrgRBC2BloodPool_Lng" dim="Amount per time" formula="Q*HCT*C_bc">
+              <Paths>
+                <Path path="23" as="16" dim="17" />
+                <Path path="18" as="24" dim="20" />
+                <Path path="21" as="22" />
+              </Paths>
+            </Formula>
+            <Formula id="Usd-3O_bSUC6ar99fPV-8Q" name="MassTransferOrgRBC2BloodPool_Pve" dim="Amount per time" formula="Q*HCT*C_bc">
+              <Paths>
+                <Path path="23" as="16" dim="17" />
+                <Path path="18" as="24" dim="20" />
+                <Path path="21" as="22" />
+              </Paths>
+            </Formula>
+            <Formula id="uqosaOCTo0W4_E7eV3QQvA" name="MassTransferPeriportal2PericentralBC_liv" dim="Amount per time" formula="IsLiverZonated ? (Q_liv +Q_pve)*HCT*C_bc : 0">
+              <Paths>
+                <Path path="23" as="36" dim="17" />
+                <Path path="18" as="24" dim="20" />
+                <Path path="39" as="40" dim="17" />
+                <Path path="21" as="22" />
+                <Path path="37" as="38" />
+              </Paths>
+            </Formula>
+            <Formula id="fX8typMREUOF35_JsbJFhg" name="MassTransferPeriportal2PericentralPl_liv" dim="Amount per time" formula="IsLiverZonated ? (Q_liv +Q_pve)*(1-HCT)*C_pls : 0">
+              <Paths>
+                <Path path="23" as="36" dim="17" />
+                <Path path="18" as="19" dim="20" />
+                <Path path="39" as="40" dim="17" />
+                <Path path="21" as="22" />
+                <Path path="37" as="38" />
+              </Paths>
+            </Formula>
+            <Formula id="cZCrlbO_HEWB6HlpsgDUDQ" name="PassiveDiffusionInt2Cell" dim="Amount per time" formula="K_water_int * PA_int_cell * C_int - K_water_cell * PA_cell_int * C_cell">
+              <Paths>
+                <Path path="41" as="42" dim="20" />
+                <Path path="18" as="43" dim="20" />
+                <Path path="44" as="45" dim="17" />
+                <Path path="46" as="47" dim="17" />
+                <Path path="48" as="49" />
+                <Path path="50" as="51" />
+              </Paths>
+            </Formula>
+            <Formula id="lRrweqoOPUSqOTC-13H2rg" name="PassiveDiffusionPl2Int" dim="Amount per time" formula="fu * P_endothelial * SA * (C_pls - C_int / K_int_pls)">
+              <Paths>
+                <Path path="41" as="43" dim="20" />
+                <Path path="18" as="19" dim="20" />
+                <Path path="52" as="53" dim="54" />
+                <Path path="55" as="56" dim="57" />
+                <Path path="58" as="59" />
+                <Path path="60" as="61" dim="62" />
+              </Paths>
+            </Formula>
+            <Formula id="39G8faBkBkWULPnnMTY0Vw" name="PassiveDiffusionPl2RBC" dim="Amount per time" formula="SA_bc * fu * (P_pls_rbc * C_pls - P_rbc_pls * C_bc  /K_rbc)">
+              <Paths>
+                <Path path="41" as="24" dim="20" />
+                <Path path="18" as="19" dim="20" />
+                <Path path="52" as="53" dim="54" />
+                <Path path="63" as="64" dim="57" />
+                <Path path="65" as="66" dim="57" />
+                <Path path="67" as="68" />
+                <Path path="69" as="70" dim="62" />
+              </Paths>
+            </Formula>
+            <Formula id="npHnQFEa102RT9WkcZFwaw" name="PassiveDiffusionPlsToSaliva" dim="Amount per time" formula="fu * (C_pls_art - C_slv / K_slv_pls) * Q_slv">
+              <Paths>
+                <Path path="71" as="72" dim="17" />
+                <Path path="73" as="74" dim="20" />
+                <Path path="41" as="75" dim="20" />
+                <Path path="52" as="53" dim="54" />
+                <Path path="76" as="77" />
+              </Paths>
+            </Formula>
+            <Formula id="BV_8avpnEUOv3WxvgZi-9w" name="GallbladderEmptyingRate" dim="Amount per time" formula="EHC_Active ? ln(2) / EHC_Halftime * M * EHC_EjectionFraction : 0">
+              <Paths>
+                <Path path="78" as="79" dim="7" />
+                <Path path="80" as="81" dim="54" />
+                <Path path="82" as="83" dim="84" />
+                <Path path="85" as="86" />
+              </Paths>
+            </Formula>
+            <Formula id="QzAJ32zZ_UOKH_H2R6jv8Q" name="TubularSecretion_FirstOrder" dim="Amount per time" formula="fu * TSspec * V_kid * C_kid_pls * Renal_aging_scaling_factor">
+              <Paths>
+                <Path path="87" as="88" dim="89" />
+                <Path path="18" as="90" dim="20" />
+                <Path path="52" as="53" dim="54" />
+                <Path path="91" as="91" dim="12" />
+                <Path path="92" as="93" />
+              </Paths>
+            </Formula>
+            <Formula id="uj7hx8HRlUiFH1IYq04UMQ" name="PARAM_TSspec_From_TS" dim="Inversed time" formula="TS / V_kid">
+              <Paths>
+                <Path path="94" as="95" dim="17" />
+                <Path path="96" as="88" dim="89" />
+              </Paths>
+            </Formula>
+            <Formula id="icYTNLU4wU60MDsnKTVvnw" name="GFR_Clearance" dim="Amount per time" formula="fu * GFRspec*GFR_Fraction* Weight_Kidney * C_kid_pls">
+              <Paths>
+                <Path path="97" as="98" dim="99" />
+                <Path path="100" as="101" dim="102" />
+                <Path path="18" as="90" dim="20" />
+                <Path path="52" as="53" dim="54" />
+                <Path path="103" as="104" dim="54" />
+              </Paths>
+            </Formula>
+          </Formulas>
+          <StringMap>
+            <Map s="NEIGHBORHOOD|MOLECULE|Drug absorption rate (lumen to mucosa)" id="0" />
+            <Map s="DrugAbsorptionLumenToMucosaRate" id="1" />
+            <Map s="Amount per time" id="2" />
+            <Map s="SOURCE|..|OralApplicationsEnabled" id="3" />
+            <Map s="OralApplicationsEnabled" id="4" />
+            <Map s="SOURCE|MOLECULE" id="5" />
+            <Map s="Drug" id="6" />
+            <Map s="Amount" id="7" />
+            <Map s="MOLECULE|Is floating in lumen" id="8" />
+            <Map s="IsFloatingInLumen" id="9" />
+            <Map s="SOURCE|Intestinal transit rate (absolute)" id="10" />
+            <Map s="w" id="11" />
+            <Map s="Inversed time" id="12" />
+            <Map s="TARGET|FillLevelFlag" id="13" />
+            <Map s="FillLevelFlagNext" id="14" />
+            <Map s="TARGET|..|Blood flow rate" id="15" />
+            <Map s="Q" id="16" />
+            <Map s="Flow" id="17" />
+            <Map s="SOURCE|MOLECULE|Concentration" id="18" />
+            <Map s="C_pls" id="19" />
+            <Map s="Concentration (molar)" id="20" />
+            <Map s="Organism|Hematocrit" id="21" />
+            <Map s="HCT" id="22" />
+            <Map s="SOURCE|..|Blood flow rate" id="23" />
+            <Map s="C_bc" id="24" />
+            <Map s="NEIGHBORHOOD|MOLECULE|Mass transfer rate (intestine to mucosa blood cells)" id="25" />
+            <Map s="MassTransferIntestineToMucosaBCRate" id="26" />
+            <Map s="NEIGHBORHOOD|MOLECULE|Mass transfer rate (intestine to mucosa plasma)" id="27" />
+            <Map s="MassTransferIntestineToMucosaPlasmaRate" id="28" />
+            <Map s="SOURCE|..|Mucosa blood flow fraction" id="29" />
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+            <Map s="C" id="31" />
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+                    <Info min="0" flag="18" seq="1" ref="0" bb="32" group="6" />
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+                  <Parameter id="YOa0vysQi0G8s2Ci6QP4-A" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="73" displayUnit="kg">
+                    <Info min="0" flag="34" seq="1" ref="0" bb="32" group="6" />
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+                <Children>
+                  <Parameter id="21VL4obBX0ylVJ1FC-4y2A" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
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+                <Tags>
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+                    <Tags>
+                      <Tag value="BloodOrgan" />
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+                    <Tags>
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+                    <Info min="0.75" max="0.75" flag="52" seq="1" ref="0" bb="32" group="2" />
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+                  <Parameter id="KdWtB981q0WEaw449m-NZA" name="Fraction vascular" description="Fraction of vascular space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
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+                      <Tag value="BloodOrgan" />
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+                      <Parameter id="punEQrScAEieMrSiDkTKiQ" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.50097470344528">
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+                        <Info min="0" flag="34" seq="1" ref="0" bb="32" group="65" />
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+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="65" />
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+                      <Tag value="BloodOrgan" />
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+                    <Tags>
+                      <Tag value="BloodOrgan" />
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+                    <Children>
+                      <Parameter id="8CF0-u84bUOFSVA2LWAm1Q" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="jUuicTjwYECqpkpEHOcv6w" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
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+                        <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
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+                        <Children>
+                          <Parameter id="6_XXwhMZMUiNB-CQ4z0N2Q" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_o63arufdk2PTQFsOiSkqg" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                          </Parameter>
+                          <Parameter id="OafBFCI_Pk26-uqJJ8mWSQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="pDRD-WocckCSQtVxG1Keug" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                          </Parameter>
+                          <Parameter id="6_EjJ4xoDEqexOtVdaP-Dw" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="3PTNCKfDA0yr8QD63uBncQ" isDefault="1" displayUnit="min">
+                            <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                        </Children>
+                      </Container>
+                    </Children>
+                  </Container>
+                  <Container id="Psihdre1OUqL7biUDEcQDw" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
+                    <Tags>
+                      <Tag value="BloodOrgan" />
+                      <Tag value="VenousBlood" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="6bYl3SiN2Eyye53E8RCzHw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="jUuicTjwYECqpkpEHOcv6w" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="5tqJebYPzUmFefhXyGyE_A" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="lQDqi5dviUeaULP3N3S_ag" isDefault="1" displayUnit="l">
+                        <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                        <Info min="0" flag="62" seq="3" ref="0" bb="2" group="121" />
+                      </Parameter>
+                      <Container id="3BtATRIfuEW-5QrwgoTWQQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
+                        <Children>
+                          <Parameter id="8Ct7eQSy1EmsR91Grf2XGw" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_o63arufdk2PTQFsOiSkqg" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                          </Parameter>
+                          <Parameter id="tXAIqu-XW0mpOWEq_8X0bA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_B4r1Pf9BEa0ce4IJUo7mA" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                          </Parameter>
+                          <Parameter id="FwBw04tWhkWD5bwzE6szLw" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="3PTNCKfDA0yr8QD63uBncQ" isDefault="1" displayUnit="min">
+                            <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                        </Children>
+                      </Container>
+                    </Children>
+                  </Container>
+                </Children>
+              </Container>
+              <Container id="0VLBk7QWP0C-BLy_hF_ksg" name="ArterialBlood" description="ArterialBlood" icon="ArterialBlood" mode="Logical" containerType="Organ">
+                <Tags>
+                  <Tag value="BloodOrgan" />
+                </Tags>
+                <Children>
+                  <Parameter id="PftktX-tCkOPDGZ7ObS0mQ" name="Weight (tissue)" description="Weight of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="wccWBS9A2kuoeEsL1_z2ww" isDefault="1" displayUnit="kg">
+                    <Tags>
+                      <Tag value="BloodOrgan" />
+                    </Tags>
+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
+                  </Parameter>
+                  <Parameter id="419g17a7FUCE0T8IJ1igqg" name="Density (tissue)" description="Density of tissue" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
+                    <Tags>
+                      <Tag value="BloodOrgan" />
+                    </Tags>
+                    <Info min="0" flag="38" seq="1" ref="0" bb="32" group="21" />
+                  </Parameter>
+                  <Parameter id="TRtC5gRcY0WjhJm_SKCm0A" name="Peripheral blood flow fraction" description="Blood flow fraction in organ used for calculation of peripheral venous blood concentrations" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0">
+                    <Tags>
+                      <Tag value="BloodOrgan" />
+                    </Tags>
+                    <ValueOrigin id="46" source="Publication" description="Thiel C, Schneckener S, Krauss M, Ghallab A, Hofmann U, et al. A systematic evaluation of the use of physiologically based pharmacokinetic modeling for cross-species extrapolation. J Pharm Sci. 2015 Jan;104(1):191-206 https://doi.org/10.1002/jps.24214" />
+                    <Info min="0" max="1" flag="122" seq="1" ref="0" bb="32" group="74" />
+                  </Parameter>
+                  <Parameter id="VyZChrD15ESyi3Ytz967FQ" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.75">
+                    <Tags>
+                      <Tag value="BloodOrgan" />
+                    </Tags>
+                    <Info min="0.75" max="0.75" flag="52" seq="1" ref="0" bb="32" group="2" />
+                  </Parameter>
+                  <Parameter id="xHn1ijFU30KU_UijWzxqtQ" name="Fraction vascular" description="Fraction of vascular space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                    <Tags>
+                      <Tag value="BloodOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="62" seq="12" ref="0" bb="32" group="64" />
+                  </Parameter>
+                  <DistributedParameter id="Vbv3eBjKEU6damTlBQrI2Q" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="8Giln7oM3UC2ztbiBOYJEw" mode="Logical" isDefault="1" displayUnit="l">
+                    <Children>
+                      <Parameter id="Du3o48jWpkqy7t938mORnw" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.500388834981007">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="65" />
+                      </Parameter>
+                      <Parameter id="CV9MiU5nXUedJKX1t4J-qA" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.419080314" displayUnit="l">
+                        <Info min="0" flag="34" seq="1" ref="0" bb="32" group="65" />
+                      </Parameter>
+                      <Parameter id="Da2tqvmMT0yd9okdaiT6Ow" name="Deviation" description="Standard deviation of Normal distribution" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.020954016" displayUnit="l">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="65" />
+                      </Parameter>
+                    </Children>
+                    <Tags>
+                      <Tag value="BloodOrgan" />
+                    </Tags>
+                    <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
+                    <Info min="0" flag="106" seq="1" ref="0" bb="32" group="65" />
+                  </DistributedParameter>
+                  <Container id="Hl-Gd6HA30OOrhWd5UIAVQ" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
+                    <Tags>
+                      <Tag value="ArterialBlood" />
+                      <Tag value="BloodOrgan" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="WUncfRN5ukOu1x7Tg4JAeA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="jUuicTjwYECqpkpEHOcv6w" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="lhJJSNuh8E-YpfhNGlPr9w" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="blTeh9R920CZdZ4A1TxD_w" isDefault="1" displayUnit="l">
+                        <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                        <Info min="0" flag="62" seq="4" ref="0" bb="2" group="126" />
+                      </Parameter>
+                      <Container id="ng7B8dQNfEqEAZxScyObWw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
+                        <Children>
+                          <Parameter id="-iZpOJq5T0CxhDn1hXBqfw" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_o63arufdk2PTQFsOiSkqg" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                          </Parameter>
+                          <Parameter id="niC8Hlak-Ue5Ju8VMhuq7Q" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="pDRD-WocckCSQtVxG1Keug" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                          </Parameter>
+                          <Parameter id="wFzJUUBE_UK0wdKy0lvQ3g" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="3PTNCKfDA0yr8QD63uBncQ" isDefault="1" displayUnit="min">
+                            <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                        </Children>
+                      </Container>
+                    </Children>
+                  </Container>
+                  <Container id="bE0VJ8a31Uyaciw1C0jzTg" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
+                    <Tags>
+                      <Tag value="ArterialBlood" />
+                      <Tag value="BloodOrgan" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="XhQ4-Z1hN0OL3FJ06XvPKg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="jUuicTjwYECqpkpEHOcv6w" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="GxOmEFzfFUmKRunOWbkHOg" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="lQDqi5dviUeaULP3N3S_ag" isDefault="1" displayUnit="l">
+                        <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                        <Info min="0" flag="62" seq="4" ref="0" bb="2" group="121" />
+                      </Parameter>
+                      <Container id="rDwo7tzMpEO8WhY-nhSdeA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
+                        <Children>
+                          <Parameter id="6ljzXDuFQEmto-PjED_60w" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_o63arufdk2PTQFsOiSkqg" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                          </Parameter>
+                          <Parameter id="smbZXG4kRkiUmR8GeIn99Q" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_B4r1Pf9BEa0ce4IJUo7mA" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                          </Parameter>
+                          <Parameter id="D8v-fYiTD0ObQMBdVfl1Nw" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="3PTNCKfDA0yr8QD63uBncQ" isDefault="1" displayUnit="min">
+                            <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                        </Children>
+                      </Container>
+                    </Children>
+                  </Container>
+                </Children>
+              </Container>
+              <Container id="MYTVw_GAKE63cK5NZwec7A" name="Bone" description="Bone" icon="Bone" mode="Logical" containerType="Organ">
+                <Tags>
+                  <Tag value="TissueOrgan" />
+                </Tags>
+                <Children>
+                  <Parameter id="4tF8COmXzUmciRZOuLX0Ww" name="Weight (tissue)" description="Weight of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="wccWBS9A2kuoeEsL1_z2ww" isDefault="1" displayUnit="kg">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
+                  </Parameter>
+                  <Parameter id="GvdmqbhnBUeyKx2q_BZfFA" name="Blood flow rate" description="Organ blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="kOPtX3xlRUyjlOOtEoP9Yg" isDefault="1" displayUnit="l/min">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="48" source="Other" description="Absolute value = specific value (i.e. value normalized to the volume of the organ) multiplied by the organ volume" />
+                    <Info min="0" flag="62" seq="2" ref="0" bb="32" group="5" />
+                  </Parameter>
+                  <Parameter id="qCbGjLdZW0my8QjmFf_luA" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="_1qGrWaZQ0-mf9ujtwqKng" isDefault="1" displayUnit="l/min">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="5" ref="0" bb="32" group="27" />
+                  </Parameter>
+                  <Parameter id="lVhAf2n8G0W660Uzxu-QYA" name="Lymph flow rate" description="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="wo_Oqj188kKCGN911xCrEw" isDefault="1" displayUnit="l/min">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="5" ref="0" bb="32" group="58" />
+                  </Parameter>
+                  <Parameter id="Li0A9VswKkWQLOK3opVzOw" name="Volume (endothelium)" description="Volume of  vascular endothelium" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="toeYhWOhTUarTdpf3IhITw" isDefault="1" displayUnit="l">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="62" seq="5" ref="0" bb="32" group="127" />
+                  </Parameter>
+                  <Parameter id="1Z0-5krNmUiEk99xJOKk9A" name="Fraction intracellular" description="Fraction of intracellular space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ZxHXV_JusU-NQSlrOekb3w" isDefault="1">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="62" seq="16" ref="0" bb="32" group="64" />
+                  </Parameter>
+                  <Parameter id="S_Ww5Xvyx0iRFD-svBvFzw" name="Density (tissue)" description="Density of tissue" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="38" seq="1" ref="0" bb="32" group="21" />
+                  </Parameter>
+                  <Parameter id="VV58N6_ibU-lJd2zK7Amcg" name="Fluid recirculation flow proportionality factor" description="proportionality factor linking fluid recirculation flow to lymph flow via small pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.96">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="27" />
+                  </Parameter>
+                  <Parameter id="MfdFdOVuiU6tC2YgDjUyMw" name="Lymph flow proportionality factor" description="Proportionality factor linking lymph flow to plasma flow" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.000662">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="58" />
+                  </Parameter>
+                  <Parameter id="R5-bwT_1uEmyum5kETYI8w" name="Organ volume mouse" description="Organ volume mouse" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.00158" displayUnit="l">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="65" />
+                  </Parameter>
+                  <Parameter id="9wDxn-CXDkaVrwLA7CHCNg" name="Peripheral blood flow fraction" description="Blood flow fraction in organ used for calculation of peripheral venous blood concentrations" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="46" source="Publication" description="Thiel C, Schneckener S, Krauss M, Ghallab A, Hofmann U, et al. A systematic evaluation of the use of physiologically based pharmacokinetic modeling for cross-species extrapolation. J Pharm Sci. 2015 Jan;104(1):191-206 https://doi.org/10.1002/jps.24214" />
+                    <Info min="0" max="1" flag="122" seq="1" ref="0" bb="32" group="74" />
+                  </Parameter>
+                  <Parameter id="CWg-v8_duUqADPaZYNnthw" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="2" max="2" flag="54" seq="1" ref="0" bb="32" group="2" />
+                  </Parameter>
+                  <Parameter id="ozhe96wR50iX3y65KgSI6g" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="54" seq="1" ref="0" bb="32" group="94" />
+                  </Parameter>
+                  <Parameter id="aZvjNrCCekufayeYFSOEDA" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.05">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" max="1" flag="122" seq="5" ref="0" bb="32" group="114" />
+                  </Parameter>
+                  <Parameter id="k-xIgMIHm0-BFdadFufV4g" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" icon="Parameter" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="9E-12" displayUnit="ml/min/N">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="5" ref="0" bb="32" group="115" />
+                  </Parameter>
+                  <Parameter id="ETGULRz7Z0eFOl3ENxqWCw" name="Radius (large pores)" description="Large endothelial pores radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.5E-07" displayUnit="µm">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
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+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
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+                    <Tags>
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+                      <Parameter id="sn5xQCjoXkqFmEubYBCcIw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="jUuicTjwYECqpkpEHOcv6w" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
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+                      <Parameter id="hCufNXWHtkKF_B-uXzAFGQ" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="V2_FdO3puUGekuCdqn4lGg" isDefault="1" displayUnit="l">
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+                        <Info min="0" flag="62" seq="5" ref="0" bb="2" group="121" />
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+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
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+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
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+                      <Tag value="Bone" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="N6mFh4iKEUC7K9OY76gjDg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="jUuicTjwYECqpkpEHOcv6w" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="Hg0WrCbtRUertpssrE1ZgQ" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="FsvYOeKl5kaJQ1JZ4JcXpg" isDefault="1" displayUnit="l">
+                        <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                        <Info min="0" flag="62" seq="5" ref="0" bb="2" group="124" />
+                      </Parameter>
+                      <Parameter id="FT7b1_-M0E6zVg0ZDS5qYA" name="pH" description="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="vNehtSpde0yreA4KgSiy2A" isDefault="1">
+                        <Tags>
+                          <Tag value="Bone" />
+                        </Tags>
+                        <Info min="0" max="14" flag="122" seq="17" ref="0" bb="32" group="84" />
+                      </Parameter>
+                      <Container id="yTYWud6o2ESdYiRpxPz_eg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
+                        <Children>
+                          <Parameter id="N0tYgRme0UqosEFg275JIw" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_o63arufdk2PTQFsOiSkqg" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                          </Parameter>
+                          <Parameter id="UcQ8n8T0v0i0rm2U9nxNcg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="2Rc44tw1R0GyB903wqsw-w" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                          </Parameter>
+                          <Parameter id="3VY5FlokUk-suA9XXzmO5g" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="3PTNCKfDA0yr8QD63uBncQ" isDefault="1" displayUnit="min">
+                            <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                        </Children>
+                      </Container>
+                    </Children>
+                  </Container>
+                  <Container id="wIeTkK9Vzki_vii_2KxnOw" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
+                    <Tags>
+                      <Tag value="Bone" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="EB38JgMT80KtZvU6OubohA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="-ijMbq55KEWxwtKNegWm3g" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="Ih2Z-JM5l0yi0DvMtVU-XA" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="nGzrbq1s0U6FgEbhM3oFgQ" isDefault="1" displayUnit="l">
+                        <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                        <Info min="0" flag="62" seq="5" ref="0" bb="2" group="125" />
+                      </Parameter>
+                      <Parameter id="3iOnKLI_r0OVUrwEpm6L0g" name="pH" description="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7">
+                        <Tags>
+                          <Tag value="Bone" />
+                        </Tags>
+                        <ValueOrigin id="34" source="Publication" description="Toxicol In Vitro. 2008 Mar;22(2):457-67 https://doi.org/10.1016/j.tiv.2007.09.010" />
+                        <Info min="0" max="14" flag="122" seq="17" ref="0" bb="32" group="83" />
+                      </Parameter>
+                      <Container id="8gy7VQXjf0WniV7wWBI2jw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
+                        <Children>
+                          <Parameter id="fmSyqRMwtUeYfurBsqnXXA" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_o63arufdk2PTQFsOiSkqg" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                          </Parameter>
+                          <Parameter id="yYaUfFcbZ060DafQoq5r4Q" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="0tLzIzlgrEuQtaqWJCE1ag" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                          </Parameter>
+                          <Parameter id="kLdESdT0pEyrs_NYIdkD9A" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="3PTNCKfDA0yr8QD63uBncQ" isDefault="1" displayUnit="min">
+                            <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                        </Children>
+                      </Container>
+                    </Children>
+                  </Container>
+                </Children>
+              </Container>
+              <Container id="cF7FrPZ-VU6lkR9nGKRj4w" name="Gallbladder" description="Bile compartment used to collect excretion to the bile" icon="Gallbladder" mode="Physical" containerType="Organ">
+                <Tags>
+                  <Tag value="Liver" />
+                </Tags>
+                <Children>
+                  <Parameter id="qUA624EM0EuJAqYomC5dfg" name="Time to complete gallbladder refilling" description="Time to complete gallbladder refilling" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="VKaDdCt7QU-8kQEibefBDg" isDefault="1" displayUnit="min">
+                    <Info min="0" flag="122" seq="3" ref="0" bb="2" group="128" />
+                  </Parameter>
+                  <Parameter id="AIkf4vQi3EK_mPXrKmT-Jw" name="Gallbladder emptying active" description="Gallbladder emptying active" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0">
+                    <Info min="0" max="1" flag="52" seq="4" ref="0" bb="2" group="128" />
+                  </Parameter>
+                  <Parameter id="LEwO4agDT0-71m3QrgtWJw" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="l">
+                    <Info min="0" flag="38" seq="666" ref="0" bb="2" group="65" />
+                  </Parameter>
+                  <Parameter id="J4DD8cWh8U6-vW9LUcRKYw" name="Gallbladder ejection half-time" description="Half time for gallbladder emptying (exponential release)" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="19.7" displayUnit="min">
+                    <Tags>
+                      <Tag value="Liver" />
+                    </Tags>
+                    <Info min="0" flag="122" seq="1" ref="0" bb="32" group="128" />
+                  </Parameter>
+                  <Parameter id="cxzKk9dHyU6utU02RCGgpw" name="Gallbladder ejection fraction" description="Fraction of liquid volume discretely ejected into the duodenum. The total liquid volume available in the gallbladder depends on the time after last gallbladder emptying and the parameter &quot;Time to complete gallbladder refilling&quot;" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.65">
+                    <Tags>
+                      <Tag value="Liver" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="2" ref="0" bb="32" group="128" />
+                  </Parameter>
+                  <Container id="ppSQYL5SkkaKy7FcICyllA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule" />
+                </Children>
+              </Container>
+              <Container id="lYnJ0bnSbE654iVML-rKmw" name="Brain" description="Brain" icon="Brain" mode="Logical" containerType="Organ">
+                <Tags>
+                  <Tag value="TissueOrgan" />
+                </Tags>
+                <Children>
+                  <Parameter id="1yXL2BzbCky6TdrWK-dvDg" name="Weight (tissue)" description="Weight of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="wccWBS9A2kuoeEsL1_z2ww" isDefault="1" displayUnit="kg">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
+                  </Parameter>
+                  <Parameter id="Q7C2F7wVtku9fhVy5lxygQ" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="_1qGrWaZQ0-mf9ujtwqKng" isDefault="1" displayUnit="l/min">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="6" ref="0" bb="32" group="27" />
+                  </Parameter>
+                  <Parameter id="xkgtQ5Dx-0mum4DxAl9Ddw" name="Lymph flow rate" description="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="wo_Oqj188kKCGN911xCrEw" isDefault="1" displayUnit="l/min">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="6" ref="0" bb="32" group="58" />
+                  </Parameter>
+                  <Parameter id="VXE3Wecb2UiMpCSC2Hc_Cw" name="Volume (endothelium)" description="Volume of  vascular endothelium" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="69uwc7hUYEqsHGYCWrRzIQ" isDefault="1" displayUnit="l">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="62" seq="6" ref="0" bb="32" group="127" />
+                  </Parameter>
+                  <Parameter id="uVpqJvyz3U2BQRmJyeZ02Q" name="Fraction intracellular" description="Fraction of intracellular space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ZxHXV_JusU-NQSlrOekb3w" isDefault="1">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="62" seq="19" ref="0" bb="32" group="64" />
+                  </Parameter>
+                  <Parameter id="RtvseZR8zUKpYSOuh21MJA" name="Blood flow rate" description="Organ blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="kOPtX3xlRUyjlOOtEoP9Yg" isDefault="1" displayUnit="l/min">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="48" source="Other" description="Absolute value = specific value (i.e. value normalized to the volume of the organ) multiplied by the organ volume" />
+                    <Info min="0" flag="62" seq="22" ref="0" bb="32" group="5" />
+                  </Parameter>
+                  <Parameter id="hZOS2P_K5kSbbrAkXlYFKA" name="Density (tissue)" description="Density of tissue" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="38" seq="1" ref="0" bb="32" group="21" />
+                  </Parameter>
+                  <Parameter id="uIhym2U5SkOajqxDV8Q7Uw" name="Fluid recirculation flow proportionality factor" description="proportionality factor linking fluid recirculation flow to lymph flow via small pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.404">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="27" />
+                  </Parameter>
+                  <Parameter id="yG24dm_R6kuX16xQVXV9mQ" name="Lymph flow proportionality factor" description="Proportionality factor linking lymph flow to plasma flow" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.27E-05">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="58" />
+                  </Parameter>
+                  <Parameter id="QN-vz7e-4EuoivjXc5g7CA" name="Organ volume mouse" description="Organ volume mouse" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.00017" displayUnit="l">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="65" />
+                  </Parameter>
+                  <Parameter id="C-tDVRSISEW_PJLWlDI0og" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="0" flag="54" seq="1" ref="0" bb="32" group="2" />
+                  </Parameter>
+                  <Parameter id="1Ju37DprXEKXlewXmFCoug" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="54" seq="1" ref="0" bb="32" group="94" />
+                  </Parameter>
+                  <Parameter id="ki9nlskjK065_DScqmoh8w" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.05">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" max="1" flag="122" seq="6" ref="0" bb="32" group="114" />
+                  </Parameter>
+                  <Parameter id="rl512rbUUECZQJ6L7Yxilw" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" icon="Parameter" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="5E-14" displayUnit="ml/min/N">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="6" ref="0" bb="32" group="115" />
+                  </Parameter>
+                  <Parameter id="zZx2uMgp0UmYA_a4Z51MPQ" name="Radius (large pores)" description="Large endothelial pores radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.5E-07" displayUnit="µm">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="6" ref="0" bb="32" group="55" />
+                  </Parameter>
+                  <Parameter id="IGbWdtna90qWCWMMBNedaw" name="Radius (small pores)" description="Small endothelial pores radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="4.5E-08" displayUnit="µm">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="6" ref="0" bb="32" group="99" />
+                  </Parameter>
+                  <Parameter id="8i-VvbdW4kqGdiahxv_Zxw" name="Fraction vascular" description="Fraction of vascular space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.039">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="40" source="Publication" description="Edginton, A.N., Schmitt, W. &amp; Willmann, S. Clin Pharmacokinet (2006) 45: 1013. https://doi.org/10.2165/00003088-200645100-00005" />
+                    <Info min="0" max="1" flag="62" seq="18" ref="0" bb="32" group="64" />
+                  </Parameter>
+                  <Parameter id="AGfXrcUCbUmshG2lPEBf2g" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.11">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
+                    <Info min="0" max="1" flag="122" seq="18" ref="0" bb="32" group="85" />
+                  </Parameter>
+                  <Parameter id="0MWbYyXmd0y7S2SLXuqCwA" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.051">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="18" ref="0" bb="32" group="86" />
+                  </Parameter>
+                  <Parameter id="INiucsKTMk-JYJFvXPVzSA" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0565">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="19" ref="0" bb="32" group="86" />
+                  </Parameter>
+                  <Parameter id="QGG7UERwj0uzdoN2eGihKQ" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.081">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
+                    <Info min="0" max="1" flag="122" seq="19" ref="0" bb="32" group="85" />
+                  </Parameter>
+                  <Parameter id="x7NnVmdJXUCjyc8txFYgXA" name="Fraction interstitial" description="Fraction of interstitial space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.004">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="19" source="Publication" description="Kawai R, Lemaire M, Steimer JL, Bruelisauer A, Niederberger W, Rowland M. Physiologically based pharmacokinetic study on a cyclosporin derivative, SDZ IMM 125. J Pharmacokinet Biopharm. 1994 Oct;22(5):327-65." />
+                    <Info min="0" max="1" flag="62" seq="20" ref="0" bb="32" group="64" />
+                  </Parameter>
+                  <Parameter id="ihtp7YUmTkiXJLe4g1a-cQ" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.048">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="22" source="Publication" description="Rodgers T, Rowland M. Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J Pharm Sci. 2006 Jun;95(6):1238-57 https://doi.org/10.1002/jps.20502" />
+                    <Info min="0" max="1" flag="122" seq="20" ref="0" bb="32" group="111" />
+                  </Parameter>
+                  <Parameter id="5hmHfFafrk-8lItKNxLclA" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="24" source="Publication" description="POULIN P, THEIL F. Prediction of Pharmacokinetics Prior to In Vivo Studies. 1. Mechanism-Based Prediction of Volume of Distribution. JOURNAL OF PHARMACEUTICAL SCIENCES, VOL. 91, NO. 1, JANUARY 2002" />
+                    <Info min="0" max="1" flag="122" seq="20" ref="0" bb="32" group="112" />
+                  </Parameter>
+                  <Parameter id="o8PHm0_DZka65NNY8dZDDA" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.041">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
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+                  </Container>
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+              </Container>
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+                <Tags>
+                  <Tag value="TissueOrgan" />
+                </Tags>
+                <Children>
+                  <Parameter id="kCbn07CkMEOH_DD4O4ctUQ" name="Weight (tissue)" description="Weight of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="wccWBS9A2kuoeEsL1_z2ww" isDefault="1" displayUnit="kg">
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+                    </Tags>
+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
+                  </Parameter>
+                  <Parameter id="KLaudDPdKkWcPt7LU4bQOg" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="_1qGrWaZQ0-mf9ujtwqKng" isDefault="1" displayUnit="l/min">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
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+                    <Info min="0" flag="122" seq="7" ref="0" bb="32" group="27" />
+                  </Parameter>
+                  <Parameter id="HxMqUWCFbEKCBgECwh41PA" name="Lymph flow rate" description="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="wo_Oqj188kKCGN911xCrEw" isDefault="1" displayUnit="l/min">
+                    <Tags>
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+                    <Info min="0" flag="122" seq="7" ref="0" bb="32" group="58" />
+                  </Parameter>
+                  <Parameter id="Y4X7KzpH7UygAEXEG2djNg" name="Volume (endothelium)" description="Volume of  vascular endothelium" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="OKXwBmpuG0CrI_8xQJdp5Q" isDefault="1" displayUnit="l">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="62" seq="7" ref="0" bb="32" group="127" />
+                  </Parameter>
+                  <Parameter id="Bs_pZ1XyG06fSRv3FZf9bA" name="Fraction intracellular" description="Fraction of intracellular space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ZxHXV_JusU-NQSlrOekb3w" isDefault="1">
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+                    <Info min="0" max="1" flag="62" seq="22" ref="0" bb="32" group="64" />
+                  </Parameter>
+                  <Parameter id="T7YDErq0p0mr6E6QKC6Smg" name="Blood flow rate" description="Organ blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="kOPtX3xlRUyjlOOtEoP9Yg" isDefault="1" displayUnit="l/min">
+                    <Tags>
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+                    <ValueOrigin id="48" source="Other" description="Absolute value = specific value (i.e. value normalized to the volume of the organ) multiplied by the organ volume" />
+                    <Info min="0" flag="62" seq="42" ref="0" bb="32" group="5" />
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+                  <Parameter id="uR6Ia92oS0uYEZhvtpPubQ" name="Density (tissue)" description="Density of tissue" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
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+                    <Info min="0" flag="38" seq="1" ref="0" bb="32" group="21" />
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+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="27" />
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+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="65" />
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+                  <Parameter id="WHuZcQ64OkKmVAbBb74rPg" name="Peripheral blood flow fraction" description="Blood flow fraction in organ used for calculation of peripheral venous blood concentrations" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
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+                    <ValueOrigin id="46" source="Publication" description="Thiel C, Schneckener S, Krauss M, Ghallab A, Hofmann U, et al. A systematic evaluation of the use of physiologically based pharmacokinetic modeling for cross-species extrapolation. J Pharm Sci. 2015 Jan;104(1):191-206 https://doi.org/10.1002/jps.24214" />
+                    <Info min="0" max="1" flag="122" seq="1" ref="0" bb="32" group="74" />
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+                    <Info min="0" flag="122" seq="7" ref="0" bb="32" group="55" />
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+                    <Info min="0" max="1" flag="122" seq="22" ref="0" bb="32" group="85" />
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+                    <Tags>
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+                    <Info min="0" max="1" flag="122" seq="23" ref="0" bb="32" group="111" />
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+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="86" />
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+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="86" />
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+                        <Info min="0" max="1" flag="50" seq="1" ref="0" bb="32" group="86" />
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+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="64" />
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+                    <Children>
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+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="85" />
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+                        <Info min="0" max="1" flag="50" seq="1" ref="0" bb="32" group="85" />
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+                    <ValueOrigin id="40" source="Publication" description="Edginton, A.N., Schmitt, W. &amp; Willmann, S. Clin Pharmacokinet (2006) 45: 1013. https://doi.org/10.2165/00003088-200645100-00005" />
+                    <Info min="0" max="1" flag="122" seq="23" ref="0" bb="32" group="85" />
+                  </DistributedParameter>
+                  <DistributedParameter id="z0S3uf8E1EOhWYpUHjmW_A" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="cxrE15ICK0-IR4z5iC8xJA" mode="Logical" isDefault="1">
+                    <Children>
+                      <Parameter id="pchCyNZ21Einwk7mObuhnA" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="86" />
+                      </Parameter>
+                      <Parameter id="IaBVFaiVI0WMbXBUuDg78w" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.18">
+                        <Info min="0" max="1" flag="50" seq="1" ref="0" bb="32" group="86" />
+                      </Parameter>
+                    </Children>
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="23" ref="0" bb="32" group="86" />
+                  </DistributedParameter>
+                  <DistributedParameter id="RmRdA7nOME6EVzu7poiOVQ" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="wsA2fu6qlUy0oIY55YHbgg" mode="Logical" isDefault="1">
+                    <Children>
+                      <Parameter id="zJ9k0Rs-4Uu9oaJCxE1Okw" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="92" />
+                      </Parameter>
+                      <Parameter id="kqjdIRrTTUqcr6pr_0apFg" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.853">
+                        <Info min="0" max="1" flag="50" seq="1" ref="0" bb="32" group="92" />
+                      </Parameter>
+                    </Children>
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="35" ref="0" bb="32" group="92" />
+                  </DistributedParameter>
+                  <DistributedParameter id="ZYRxRObIQU69px1FCVef0A" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="y7HIcTWtfEOCnE9tettRgQ" mode="Logical" isDefault="1">
+                    <Children>
+                      <Parameter id="SFUIUSfE3EqX4GoV0J6v3w" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="95" />
+                      </Parameter>
+                      <Parameter id="9DtVIn7Z1E2hFXvgg6xT6A" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.92">
+                        <Info min="0" max="1" flag="50" seq="1" ref="0" bb="32" group="95" />
+                      </Parameter>
+                    </Children>
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="35" ref="0" bb="32" group="95" />
+                  </DistributedParameter>
+                  <DistributedParameter id="c1fpxLgOXE2Ju678J-XU0w" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="iAX_Yq364E-_87ndJiCosA" mode="Logical" isDefault="1">
+                    <Children>
+                      <Parameter id="u4G24sC8G0iZ2Q0PeFaNcA" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="92" />
+                      </Parameter>
+                      <Parameter id="dD3vB8NQfEewM9tcuEqi6g" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0016">
+                        <Info min="0" max="1" flag="50" seq="1" ref="0" bb="32" group="92" />
+                      </Parameter>
+                    </Children>
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="36" ref="0" bb="32" group="92" />
+                  </DistributedParameter>
+                  <DistributedParameter id="agocq_milUWJ4KCoMla8jg" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="H7bqFXVg1UaTP57wA6z0ag" mode="Logical" isDefault="1">
+                    <Children>
+                      <Parameter id="JiCIUivWgUCy8I2wdsIz1Q" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="95" />
+                      </Parameter>
+                      <Parameter id="DyPrSW4IHEqKJ3YrQDeT3Q" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.002024">
+                        <Info min="0" max="1" flag="50" seq="1" ref="0" bb="32" group="95" />
+                      </Parameter>
+                    </Children>
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="36" ref="0" bb="32" group="95" />
+                  </DistributedParameter>
+                  <DistributedParameter id="c4djvtB7y0KD2px1E8VCnA" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ZOnbv4tZHkOToCC8w2rxGg" mode="Logical" isDefault="1">
+                    <Children>
+                      <Parameter id="Bg3kkTcva0iZphU76Uxwzw" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="92" />
+                      </Parameter>
+                      <Parameter id="TS5lZ38GA0egaQ-15a4fAA" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.135">
+                        <Info min="0" max="1" flag="50" seq="1" ref="0" bb="32" group="92" />
+                      </Parameter>
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+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="37" ref="0" bb="32" group="92" />
+                  </DistributedParameter>
+                  <DistributedParameter id="94NrRt_OjEe_Xbo7-ejrWg" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IuEF2pMUJU2sbFtW0DzwfA" mode="Logical" isDefault="1">
+                    <Children>
+                      <Parameter id="VTd-rhH3lkqN7BU_LanuNw" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="92" />
+                      </Parameter>
+                      <Parameter id="HIr4MCcVJkWLDBAcdblh0w" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.00899999999999998">
+                        <Info min="0" max="1" flag="50" seq="1" ref="0" bb="32" group="92" />
+                      </Parameter>
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+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="38" ref="0" bb="32" group="92" />
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+                  <DistributedParameter id="3WesFOlJ40eNn_GoRB3-5Q" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ep40pMrHW0WIoP661e6JVg" mode="Logical" isDefault="1">
+                    <Children>
+                      <Parameter id="-mdLSWuYcUyOWn_sEEKWXQ" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="95" />
+                      </Parameter>
+                      <Parameter id="zkgy4eKE3ECR34yOZGzE6g" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.03">
+                        <Info min="0" max="1" flag="50" seq="1" ref="0" bb="32" group="95" />
+                      </Parameter>
+                    </Children>
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="38" ref="0" bb="32" group="95" />
+                  </DistributedParameter>
+                  <DistributedParameter id="-nZ0LzOQB06fkBRBtcAcGg" name="Specific blood flow rate" description="Blood flow rate normalized to the organ volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" formula="PPFWi2qR-UKqcr00F9gmag" mode="Logical" isDefault="1" displayUnit="ml/min/100g organ">
+                    <Children>
+                      <Parameter id="3GBrOCLno0iw69NF_2Xqog" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="5" />
+                      </Parameter>
+                      <Parameter id="-EBzEJKFOUWqYf6WfVhn6w" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.02184" displayUnit="ml/min/100g organ">
+                        <Info min="0" flag="50" seq="1" ref="0" bb="32" group="5" />
+                      </Parameter>
+                      <Parameter id="TKAnslk7RkiftOFEuJgHXw" name="Deviation" description="Standard deviation of Normal distribution" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.001092" displayUnit="ml/min/100g organ">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="5" />
+                      </Parameter>
+                    </Children>
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="40" source="Publication" description="Edginton, A.N., Schmitt, W. &amp; Willmann, S. Clin Pharmacokinet (2006) 45: 1013. https://doi.org/10.2165/00003088-200645100-00005" />
+                    <Info min="0" flag="122" seq="41" ref="0" bb="32" group="5" />
+                  </DistributedParameter>
+                  <Container id="hrh6Bbq1yECrUjUyce8Xvg" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
+                    <Tags>
+                      <Tag value="Fat" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="-hMJc_9cIEmiBeSaTxXLtg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="jUuicTjwYECqpkpEHOcv6w" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="S_dzX3olukOdWSkEVdC1kg" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="2ErPZJcYvUyL3QogRRKmZg" isDefault="1" displayUnit="l">
+                        <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                        <Info min="0" flag="62" seq="7" ref="0" bb="2" group="126" />
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+                      <Container id="urok0oxpnEutbUXF-1YgpA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
+                        <Children>
+                          <Parameter id="5xfE7FeUpkuo_cPbyP_soA" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_o63arufdk2PTQFsOiSkqg" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                          </Parameter>
+                          <Parameter id="Gd9Vn3SQgU2i5pdU8I3Pyw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="pDRD-WocckCSQtVxG1Keug" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                          </Parameter>
+                          <Parameter id="FF-1oC7DNE-_0wlSpcsnPA" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="3PTNCKfDA0yr8QD63uBncQ" isDefault="1" displayUnit="min">
+                            <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
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+                    </Children>
+                  </Container>
+                  <Container id="y-Nrpm_4AEGF3WJNdy4pUQ" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
+                    <Tags>
+                      <Tag value="Fat" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="77GqaSz-e0SXMzg66c04Ug" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="jUuicTjwYECqpkpEHOcv6w" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="SdcHJyeAYkm4rV5SplUhOQ" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="V2_FdO3puUGekuCdqn4lGg" isDefault="1" displayUnit="l">
+                        <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                        <Info min="0" flag="62" seq="7" ref="0" bb="2" group="121" />
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+                      <Container id="IEg3QQ1Jw0CJztYVKdlE_w" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
+                        <Children>
+                          <Parameter id="0Fqoh8TalEC-Jh1txBD5Sg" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_o63arufdk2PTQFsOiSkqg" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                          </Parameter>
+                          <Parameter id="feaMIaXvuEidhdARnTqFZg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_B4r1Pf9BEa0ce4IJUo7mA" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
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+                          <Parameter id="RmVqnWZjr0Wp2b16ZvkflA" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="3PTNCKfDA0yr8QD63uBncQ" isDefault="1" displayUnit="min">
+                            <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
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+                    <Tags>
+                      <Tag value="Fat" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="kJvzpasxgEiWiMAwANaSMQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="jUuicTjwYECqpkpEHOcv6w" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="WNeT3TCxwk-sJmvqaIEkmg" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="FsvYOeKl5kaJQ1JZ4JcXpg" isDefault="1" displayUnit="l">
+                        <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                        <Info min="0" flag="62" seq="7" ref="0" bb="2" group="124" />
+                      </Parameter>
+                      <Parameter id="2PmrEhkvb02SJOmdBhxREg" name="pH" description="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="vNehtSpde0yreA4KgSiy2A" isDefault="1">
+                        <Tags>
+                          <Tag value="Fat" />
+                        </Tags>
+                        <Info min="0" max="14" flag="122" seq="23" ref="0" bb="32" group="84" />
+                      </Parameter>
+                      <Container id="j0o19RC_7UqsjUVpJtJs_A" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
+                        <Children>
+                          <Parameter id="P3BePo1yH06eo1KxlS39xg" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_o63arufdk2PTQFsOiSkqg" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                          </Parameter>
+                          <Parameter id="iosVBeE-G0O3QjBdpKFBWw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="RQ_T_QP_yEmlEtR0xxovXA" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                          </Parameter>
+                          <Parameter id="tPSbT_yP7kenbgHauDZ2VA" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="3PTNCKfDA0yr8QD63uBncQ" isDefault="1" displayUnit="min">
+                            <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                        </Children>
+                      </Container>
+                    </Children>
+                  </Container>
+                  <Container id="Ir0opX_oJUK91yMOaPMmSQ" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
+                    <Tags>
+                      <Tag value="Fat" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="qdwcVLUscU-2tdgMqCNb7A" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="-ijMbq55KEWxwtKNegWm3g" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="F8gBCH7v-k6BUcwgxcOJkQ" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="nGzrbq1s0U6FgEbhM3oFgQ" isDefault="1" displayUnit="l">
+                        <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                        <Info min="0" flag="62" seq="7" ref="0" bb="2" group="125" />
+                      </Parameter>
+                      <Parameter id="kIfgMpDrZk-LHkLGtZDWiQ" name="pH" description="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.1">
+                        <Tags>
+                          <Tag value="Fat" />
+                        </Tags>
+                        <ValueOrigin id="34" source="Publication" description="Toxicol In Vitro. 2008 Mar;22(2):457-67 https://doi.org/10.1016/j.tiv.2007.09.010" />
+                        <Info min="0" max="14" flag="122" seq="23" ref="0" bb="32" group="83" />
+                      </Parameter>
+                      <Container id="HdRD0cNjEEaPyZJn3WXsqw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
+                        <Children>
+                          <Parameter id="xZ0BzYLuLEmklV5C7ivwhg" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_o63arufdk2PTQFsOiSkqg" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                          </Parameter>
+                          <Parameter id="20N-Q88WtEy78LKa_v3KGw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="mDaF0RwTc0Wa5VuCWstePQ" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                          </Parameter>
+                          <Parameter id="etSWR7xlu0izWlfNVz8L_A" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="3PTNCKfDA0yr8QD63uBncQ" isDefault="1" displayUnit="min">
+                            <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                        </Children>
+                      </Container>
+                    </Children>
+                  </Container>
+                </Children>
+              </Container>
+              <Container id="YMdLpYOSkUGZc-FRNc33mw" name="Gonads" description="Gonads" icon="Gonads" mode="Logical" containerType="Organ">
+                <Tags>
+                  <Tag value="TissueOrgan" />
+                </Tags>
+                <Children>
+                  <Parameter id="WX2tNSmB1Um0GMkKirEI2w" name="Weight (tissue)" description="Weight of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="wccWBS9A2kuoeEsL1_z2ww" isDefault="1" displayUnit="kg">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
+                  </Parameter>
+                  <Parameter id="YPQRLKRA6kOltqkYZcn4GQ" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="_1qGrWaZQ0-mf9ujtwqKng" isDefault="1" displayUnit="l/min">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="10" ref="0" bb="32" group="27" />
+                  </Parameter>
+                  <Parameter id="FXth3jrZBUWBT9U8Y4a_AA" name="Lymph flow rate" description="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="wo_Oqj188kKCGN911xCrEw" isDefault="1" displayUnit="l/min">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="10" ref="0" bb="32" group="58" />
+                  </Parameter>
+                  <Parameter id="3eR8XBOUdE-rShOZG3Gpxg" name="Volume (endothelium)" description="Volume of  vascular endothelium" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="LgMw4nwIXkSAZXoZdkP9XA" isDefault="1" displayUnit="l">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="62" seq="10" ref="0" bb="32" group="127" />
+                  </Parameter>
+                  <Parameter id="cKQqm6vmHE2N83g7JwG1Bw" name="Fraction intracellular" description="Fraction of intracellular space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ZxHXV_JusU-NQSlrOekb3w" isDefault="1">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="62" seq="31" ref="0" bb="32" group="64" />
+                  </Parameter>
+                  <Parameter id="c-CSps8Uj0av2PBVgbP69Q" name="Blood flow rate" description="Organ blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="kOPtX3xlRUyjlOOtEoP9Yg" isDefault="1" displayUnit="l/min">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="48" source="Other" description="Absolute value = specific value (i.e. value normalized to the volume of the organ) multiplied by the organ volume" />
+                    <Info min="0" flag="62" seq="62" ref="0" bb="32" group="5" />
+                  </Parameter>
+                  <Parameter id="gFlpYquuaUynn2UtRLSTcA" name="Density (tissue)" description="Density of tissue" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="38" seq="1" ref="0" bb="32" group="21" />
+                  </Parameter>
+                  <Parameter id="phUAqXCiY0GUlce-hizkAQ" name="Fluid recirculation flow proportionality factor" description="proportionality factor linking fluid recirculation flow to lymph flow via small pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.96">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="27" />
+                  </Parameter>
+                  <Parameter id="-5tcStiqNEercVvPCwmaJA" name="Lymph flow proportionality factor" description="Proportionality factor linking lymph flow to plasma flow" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0111">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="58" />
+                  </Parameter>
+                  <Parameter id="vQ9-M4oCgUiJZO5hOPxu3A" name="Organ volume mouse" description="Organ volume mouse" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.00025" displayUnit="l">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="65" />
+                  </Parameter>
+                  <Parameter id="W_VLBfB5h0S_G7H362x5-w" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.75">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0.75" max="0.75" flag="54" seq="1" ref="0" bb="32" group="2" />
+                  </Parameter>
+                  <Parameter id="uHhhGfZoOESz00S-EuDxQA" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="54" seq="1" ref="0" bb="32" group="94" />
+                  </Parameter>
+                  <Parameter id="WtVL2NK8zkyzXH5Q9ntGnw" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.05">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" max="1" flag="122" seq="10" ref="0" bb="32" group="114" />
+                  </Parameter>
+                  <Parameter id="iXPuAksLCUuQP_1egycoDw" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" icon="Parameter" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="9E-12" displayUnit="ml/min/N">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="10" ref="0" bb="32" group="115" />
+                  </Parameter>
+                  <Parameter id="ea5DikUCckCs9hjG2804Xg" name="Radius (large pores)" description="Large endothelial pores radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.5E-07" displayUnit="µm">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="10" ref="0" bb="32" group="55" />
+                  </Parameter>
+                  <Parameter id="7jo9qxzp40eUyQpljXwKOA" name="Radius (small pores)" description="Small endothelial pores radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="4.5E-08" displayUnit="µm">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="10" ref="0" bb="32" group="99" />
+                  </Parameter>
+                  <Parameter id="WIE0lWiDGkCmYW2z3rJd8g" name="Fraction vascular" description="Fraction of vascular space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.055">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="40" source="Publication" description="Edginton, A.N., Schmitt, W. &amp; Willmann, S. Clin Pharmacokinet (2006) 45: 1013. https://doi.org/10.2165/00003088-200645100-00005" />
+                    <Info min="0" max="1" flag="62" seq="30" ref="0" bb="32" group="64" />
+                  </Parameter>
+                  <Parameter id="yFqG0Lxxf0-aqlKMqHyrTg" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.031">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
+                    <Info min="0" max="1" flag="122" seq="30" ref="0" bb="32" group="85" />
+                  </Parameter>
+                  <Parameter id="ZeaI5g8sIEaB4LHA_G8fcQ" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0048">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="30" ref="0" bb="32" group="86" />
+                  </Parameter>
+                  <Parameter id="1oke5_NQDEGXNRxaQ4aeBQ" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.01405">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="31" ref="0" bb="32" group="86" />
+                  </Parameter>
+                  <Parameter id="JNheY_GeAEu6uBxJtQPqtg" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.12">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
+                    <Info min="0" max="1" flag="122" seq="31" ref="0" bb="32" group="85" />
+                  </Parameter>
+                  <Parameter id="E1h4Tvmld02aaP0DdcjGcQ" name="Fraction interstitial" description="Fraction of interstitial space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.069">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="40" source="Publication" description="Edginton, A.N., Schmitt, W. &amp; Willmann, S. Clin Pharmacokinet (2006) 45: 1013. https://doi.org/10.2165/00003088-200645100-00005" />
+                    <Info min="0" max="1" flag="62" seq="32" ref="0" bb="32" group="64" />
+                  </Parameter>
+                  <Parameter id="67tumhdYh0qiqm0sGkfzAA" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.048">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="32" ref="0" bb="32" group="111" />
+                  </Parameter>
+                  <Parameter id="-tU3i3zlvkCiKOaq7kLdCg" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="24" source="Publication" description="POULIN P, THEIL F. Prediction of Pharmacokinetics Prior to In Vivo Studies. 1. Mechanism-Based Prediction of Volume of Distribution. JOURNAL OF PHARMACEUTICAL SCIENCES, VOL. 91, NO. 1, JANUARY 2002" />
+                    <Info min="0" max="1" flag="122" seq="32" ref="0" bb="32" group="112" />
+                  </Parameter>
+                  <Parameter id="qi0Ffpx1AE-RAGcChJPt6w" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.041">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="32" ref="0" bb="32" group="113" />
+                  </Parameter>
+                  <Parameter id="GH6fOla2KkmmEzgokOioZA" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.8">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
+                    <Info min="0" max="1" flag="122" seq="32" ref="0" bb="32" group="85" />
+                  </Parameter>
+                  <Parameter id="HsLGK6cYe0SxVS5OkhVzDw" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.8">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="32" ref="0" bb="32" group="86" />
+                  </Parameter>
+                  <Parameter id="eC6l5ymQREavxBoAHh7U5g" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0048">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
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+                    <Info min="0" max="1" flag="122" seq="50" ref="0" bb="32" group="92" />
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+                  <Parameter id="ypOxvRm24EeCIdcKrNdzvg" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="50" ref="0" bb="32" group="95" />
+                  </Parameter>
+                  <Parameter id="uOk6GpPlfEKKFwdokISCuA" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0116">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="51" ref="0" bb="32" group="92" />
+                  </Parameter>
+                  <Parameter id="Fm-cluxFF0ePyojLwHN0wQ" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0249">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="51" ref="0" bb="32" group="95" />
+                  </Parameter>
+                  <Parameter id="5wFXdzJRhEaiBvJt2c1huw" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.03">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="20" source="Publication" description="Rodgers T, Leahy D, Rowland M. Tissue distribution of basic drugs: accounting for enantiomeric, compound and regional differences amongst beta-blocking drugs in rat. J Pharm Sci. 2005 Jun;94(6):1237-48. https://doi.org/10.1002/jps.20323" />
+                    <Info min="0" max="1" flag="122" seq="52" ref="0" bb="32" group="92" />
+                  </Parameter>
+                  <Parameter id="tKhVUCJW50SjX5I3liQ71w" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.13">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="52" ref="0" bb="32" group="95" />
+                  </Parameter>
+                  <Parameter id="jXKvEAsCp06WyPr_lHc8ZQ" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.83">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="20" source="Publication" description="Rodgers T, Leahy D, Rowland M. Tissue distribution of basic drugs: accounting for enantiomeric, compound and regional differences amongst beta-blocking drugs in rat. J Pharm Sci. 2005 Jun;94(6):1237-48. https://doi.org/10.1002/jps.20323" />
+                    <Info min="0" max="1" flag="122" seq="53" ref="0" bb="32" group="92" />
+                  </Parameter>
+                  <Parameter id="RRx3vabw2EavW1bqpgZrLA" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.78">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="53" ref="0" bb="32" group="95" />
+                  </Parameter>
+                  <Parameter id="dCguO4tToU6SqDh8_p34-g" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.45">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="20" source="Publication" description="Rodgers T, Leahy D, Rowland M. Tissue distribution of basic drugs: accounting for enantiomeric, compound and regional differences amongst beta-blocking drugs in rat. J Pharm Sci. 2005 Jun;94(6):1237-48. https://doi.org/10.1002/jps.20323" />
+                    <Info min="0" max="1000" flag="122" seq="54" ref="0" bb="32" group="92" />
+                  </Parameter>
+                  <Parameter id="GDhZZ35Y5EeZJCe57qMpBw" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0054">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="54" ref="0" bb="32" group="95" />
+                  </Parameter>
+                  <DistributedParameter id="jpybDFtROEiTBxqRCsZRHQ" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="K45B5rJnqkWJvwjceZjcgA" mode="Logical" isDefault="1" displayUnit="l">
+                    <Children>
+                      <Parameter id="3UNaRWjBVkK_DdfcFHOyHQ" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.50001668930209">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="65" />
+                      </Parameter>
+                      <Parameter id="Vi6Oiym2OUixAfWcUM2iEw" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.040268154912" displayUnit="l">
+                        <Info min="0" flag="34" seq="1" ref="0" bb="32" group="65" />
+                      </Parameter>
+                      <Parameter id="fiRMJdQUXk2pcbj5_MhzMQ" name="Deviation" description="Standard deviation of Normal distribution" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0020134077456" displayUnit="l">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="65" />
+                      </Parameter>
+                    </Children>
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
+                    <Info min="0" flag="106" seq="5" ref="0" bb="32" group="65" />
+                  </DistributedParameter>
+                  <DistributedParameter id="B3U6lg2y2UuRpj3rbvI2Fg" name="Specific blood flow rate" description="Blood flow rate normalized to the organ volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" formula="ov4GJ4O5sEmJUEPIIoYTxA" mode="Logical" isDefault="1" displayUnit="ml/min/100g organ">
+                    <Children>
+                      <Parameter id="gmKq0acGT0miQ1gm5szTIA" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="5" />
+                      </Parameter>
+                      <Parameter id="71IIv_ysgUWd3weIGH4fRQ" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0806" displayUnit="ml/min/100g organ">
+                        <Info min="0" flag="50" seq="1" ref="0" bb="32" group="5" />
+                      </Parameter>
+                      <Parameter id="mITwdK94C0-9n2oY2BoOlw" name="Deviation" description="Standard deviation of Normal distribution" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.00403" displayUnit="ml/min/100g organ">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="5" />
+                      </Parameter>
+                    </Children>
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="40" source="Publication" description="Edginton, A.N., Schmitt, W. &amp; Willmann, S. Clin Pharmacokinet (2006) 45: 1013. https://doi.org/10.2165/00003088-200645100-00005" />
+                    <Info min="0" flag="122" seq="61" ref="0" bb="32" group="5" />
+                  </DistributedParameter>
+                  <Container id="yPB5n3md30-4KI9XTzIWaA" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
+                    <Tags>
+                      <Tag value="Gonads" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="_XtLaLZuL0aIpBxviL51Jg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="jUuicTjwYECqpkpEHOcv6w" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="w9pXrSyL9EmSQWUXMUVawQ" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="2ErPZJcYvUyL3QogRRKmZg" isDefault="1" displayUnit="l">
+                        <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                        <Info min="0" flag="62" seq="10" ref="0" bb="2" group="126" />
+                      </Parameter>
+                      <Container id="q-oNcF4J-UqniynDawNqVA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
+                        <Children>
+                          <Parameter id="jmIetOtpyEqWPuDuD1cUKg" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_o63arufdk2PTQFsOiSkqg" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                          </Parameter>
+                          <Parameter id="qOC5TR-RvUSLxWpNbm9BWw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="pDRD-WocckCSQtVxG1Keug" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                          </Parameter>
+                          <Parameter id="M2c2s_2ExUyX_o-YBVxdxA" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="3PTNCKfDA0yr8QD63uBncQ" isDefault="1" displayUnit="min">
+                            <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                        </Children>
+                      </Container>
+                    </Children>
+                  </Container>
+                  <Container id="PDxTJKGF10G81bGQzM6xCA" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
+                    <Tags>
+                      <Tag value="Gonads" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="IJe6OXXH5kOMuOkBtaURLQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="jUuicTjwYECqpkpEHOcv6w" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="4PNkKavRJESzqhRsxt3Wow" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="V2_FdO3puUGekuCdqn4lGg" isDefault="1" displayUnit="l">
+                        <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                        <Info min="0" flag="62" seq="10" ref="0" bb="2" group="121" />
+                      </Parameter>
+                      <Container id="yukaOugnSkOD0eA6pdOtpg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
+                        <Children>
+                          <Parameter id="GFBq46TY5Eq5WCfCbQmO5w" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_o63arufdk2PTQFsOiSkqg" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                          </Parameter>
+                          <Parameter id="IIydwmhohUCY_-7t4OxJ7Q" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_B4r1Pf9BEa0ce4IJUo7mA" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                          </Parameter>
+                          <Parameter id="_RpFEyRNWEOgpFEfxPfVLQ" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="3PTNCKfDA0yr8QD63uBncQ" isDefault="1" displayUnit="min">
+                            <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                        </Children>
+                      </Container>
+                    </Children>
+                  </Container>
+                  <Container id="1LmvpJQ9KkmJ_aDJzspkcg" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
+                    <Tags>
+                      <Tag value="Gonads" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="UEQShW_9rEuEfTejrh83_Q" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="jUuicTjwYECqpkpEHOcv6w" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="8aggFm9c2kun52k9I7JcgA" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="FsvYOeKl5kaJQ1JZ4JcXpg" isDefault="1" displayUnit="l">
+                        <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                        <Info min="0" flag="62" seq="10" ref="0" bb="2" group="124" />
+                      </Parameter>
+                      <Parameter id="Gsjha5KyMkap5mAKYd9Ixg" name="pH" description="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="vNehtSpde0yreA4KgSiy2A" isDefault="1">
+                        <Tags>
+                          <Tag value="Gonads" />
+                        </Tags>
+                        <Info min="0" max="14" flag="122" seq="32" ref="0" bb="32" group="84" />
+                      </Parameter>
+                      <Container id="Y2pju1Bpc0a7bdC2Fn36dA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
+                        <Children>
+                          <Parameter id="_HxIYr8yAEq-G--E3dzUOw" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_o63arufdk2PTQFsOiSkqg" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                          </Parameter>
+                          <Parameter id="vKLLvItR7USWnkTCH4w88w" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="N2hPp5qe60SUp4mIQ5lCkg" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                          </Parameter>
+                          <Parameter id="HG0q-cXxcU2BLu2qNunaMw" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="3PTNCKfDA0yr8QD63uBncQ" isDefault="1" displayUnit="min">
+                            <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                        </Children>
+                      </Container>
+                    </Children>
+                  </Container>
+                  <Container id="4LStjMi3mUabzS2qaRoDIA" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
+                    <Tags>
+                      <Tag value="Gonads" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="-eAouYRPO02VMyGQYKpqcA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="-ijMbq55KEWxwtKNegWm3g" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="wDrK5QaPGk68Xw204VQiYA" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="nGzrbq1s0U6FgEbhM3oFgQ" isDefault="1" displayUnit="l">
+                        <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                        <Info min="0" flag="62" seq="10" ref="0" bb="2" group="125" />
+                      </Parameter>
+                      <Parameter id="9AsI46r4g0umMN41A2OHQw" name="pH" description="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7">
+                        <Tags>
+                          <Tag value="Gonads" />
+                        </Tags>
+                        <ValueOrigin id="34" source="Publication" description="Toxicol In Vitro. 2008 Mar;22(2):457-67 https://doi.org/10.1016/j.tiv.2007.09.010" />
+                        <Info min="0" max="14" flag="122" seq="32" ref="0" bb="32" group="83" />
+                      </Parameter>
+                      <Container id="O5a3_ALEu0ifSIIdMyTG9A" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
+                        <Children>
+                          <Parameter id="U7gvhIM72EWBYGi2eV_m_Q" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_o63arufdk2PTQFsOiSkqg" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                          </Parameter>
+                          <Parameter id="jY18uGoBiEmmA3AWfJAPvg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="HRTVQ7cK3EOp_wT7Ye0TRw" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                          </Parameter>
+                          <Parameter id="WsikW7KCykGOBu0wtuaeyQ" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="3PTNCKfDA0yr8QD63uBncQ" isDefault="1" displayUnit="min">
+                            <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                        </Children>
+                      </Container>
+                    </Children>
+                  </Container>
+                </Children>
+              </Container>
+              <Container id="WP31L4pix0W_-kHKc3ECvg" name="Heart" description="Heart" icon="Heart" mode="Logical" containerType="Organ">
+                <Tags>
+                  <Tag value="TissueOrgan" />
+                </Tags>
+                <Children>
+                  <Parameter id="MuC2RjoAgk6UL4-A2fjiyA" name="Weight (tissue)" description="Weight of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="wccWBS9A2kuoeEsL1_z2ww" isDefault="1" displayUnit="kg">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
+                  </Parameter>
+                  <Parameter id="37ZeTGkcq0up6ukzAwR5OQ" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="_1qGrWaZQ0-mf9ujtwqKng" isDefault="1" displayUnit="l/min">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="11" ref="0" bb="32" group="27" />
+                  </Parameter>
+                  <Parameter id="Sa4CQyFxQ0-rulWLL7MHcA" name="Lymph flow rate" description="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="wo_Oqj188kKCGN911xCrEw" isDefault="1" displayUnit="l/min">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="11" ref="0" bb="32" group="58" />
+                  </Parameter>
+                  <Parameter id="DPWYpF2fVkm63mEmQSD5vQ" name="Volume (endothelium)" description="Volume of  vascular endothelium" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="OBi7L86YIka1gsv-9CviAQ" isDefault="1" displayUnit="l">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="62" seq="11" ref="0" bb="32" group="127" />
+                  </Parameter>
+                  <Parameter id="_xZio12ItUKUn-BAunSFcg" name="Fraction intracellular" description="Fraction of intracellular space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ZxHXV_JusU-NQSlrOekb3w" isDefault="1">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="62" seq="34" ref="0" bb="32" group="64" />
+                  </Parameter>
+                  <Parameter id="hob9TvuvOEWDuTg9vjW6hQ" name="Blood flow rate" description="Organ blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="kOPtX3xlRUyjlOOtEoP9Yg" isDefault="1" displayUnit="l/min">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="48" source="Other" description="Absolute value = specific value (i.e. value normalized to the volume of the organ) multiplied by the organ volume" />
+                    <Info min="0" flag="62" seq="82" ref="0" bb="32" group="5" />
+                  </Parameter>
+                  <Parameter id="SdpYkUR-JEKkImn98aHbtg" name="Density (tissue)" description="Density of tissue" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="38" seq="1" ref="0" bb="32" group="21" />
+                  </Parameter>
+                  <Parameter id="y18khTA340qXDV7600MKHw" name="Fluid recirculation flow proportionality factor" description="proportionality factor linking fluid recirculation flow to lymph flow via small pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.96">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="27" />
+                  </Parameter>
+                  <Parameter id="3RtOOEm_2E27SheSjPhZ1A" name="Lymph flow proportionality factor" description="Proportionality factor linking lymph flow to plasma flow" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.00147">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="58" />
+                  </Parameter>
+                  <Parameter id="lDh3_kRCHkKNUQ-m3YyvVA" name="Organ volume mouse" description="Organ volume mouse" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="9.5E-05" displayUnit="l">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="65" />
+                  </Parameter>
+                  <Parameter id="BS6pJRh_Pkabwq1h7pbXOQ" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.75">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0.75" max="0.75" flag="54" seq="1" ref="0" bb="32" group="2" />
+                  </Parameter>
+                  <Parameter id="pVJ5QfpT9kGGVWFmXqCulw" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="54" seq="1" ref="0" bb="32" group="94" />
+                  </Parameter>
+                  <Parameter id="l4KrTs7dEEyyDIBk5Jm6CQ" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.05">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" max="1" flag="122" seq="11" ref="0" bb="32" group="114" />
+                  </Parameter>
+                  <Parameter id="EJOUzOdP6U6UUHAJqRI4rQ" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" icon="Parameter" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.43333333333333E-11" displayUnit="ml/min/N">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="11" ref="0" bb="32" group="115" />
+                  </Parameter>
+                  <Parameter id="7gplyXteXEeq5qboRaNlkA" name="Radius (large pores)" description="Large endothelial pores radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.5E-07" displayUnit="µm">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="11" ref="0" bb="32" group="55" />
+                  </Parameter>
+                  <Parameter id="gtfUaxRqb0elIz9eAc_OaQ" name="Radius (small pores)" description="Small endothelial pores radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="4.5E-08" displayUnit="µm">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="11" ref="0" bb="32" group="99" />
+                  </Parameter>
+                  <Parameter id="QQHRYFhKwUGzBve77GEO1w" name="Fraction vascular" description="Fraction of vascular space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.14">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
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+                    <Info min="0" max="1" flag="122" seq="33" ref="0" bb="32" group="85" />
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+                      <Tag value="TissueOrgan" />
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+                    <Info min="0" max="1" flag="122" seq="33" ref="0" bb="32" group="86" />
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+                    <Info min="0" max="1" flag="122" seq="34" ref="0" bb="32" group="86" />
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+                    <Info min="0" max="1" flag="122" seq="34" ref="0" bb="32" group="85" />
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+                  <Parameter id="yUtYqhCS1USr2o-tOtHKnA" name="Fraction interstitial" description="Fraction of interstitial space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.1">
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+                      <Tag value="TissueOrgan" />
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+                    <ValueOrigin id="19" source="Publication" description="Kawai R, Lemaire M, Steimer JL, Bruelisauer A, Niederberger W, Rowland M. Physiologically based pharmacokinetic study on a cyclosporin derivative, SDZ IMM 125. J Pharmacokinet Biopharm. 1994 Oct;22(5):327-65." />
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+                    <Info min="0" max="1" flag="122" seq="57" ref="0" bb="32" group="92" />
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+                        <Info min="0" flag="34" seq="1" ref="0" bb="32" group="65" />
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+                        <Info min="0" flag="50" seq="1" ref="0" bb="32" group="5" />
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+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="5" />
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+                      <Parameter id="uy6tiPPO-Eih7HrGGgDMRQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="jUuicTjwYECqpkpEHOcv6w" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
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+                            <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
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+                    <Tags>
+                      <Tag value="Heart" />
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+                      <Parameter id="EMjjtmwI80GAV8GH0FLc4Q" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="jUuicTjwYECqpkpEHOcv6w" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
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+                      <Parameter id="z2tIFhfk1k2xDKUnb6B5YA" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="V2_FdO3puUGekuCdqn4lGg" isDefault="1" displayUnit="l">
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+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
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+                          <Parameter id="H7jvsGcJq0W40O59mlTYRg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_B4r1Pf9BEa0ce4IJUo7mA" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
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+                            <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
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+                    <Tags>
+                      <Tag value="Heart" />
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+                      <Parameter id="hhtdp1yo7UO5KO--00Bv9Q" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="jUuicTjwYECqpkpEHOcv6w" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
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+                      <Parameter id="HAYZZnmiRUKuOCo7c1YESA" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="FsvYOeKl5kaJQ1JZ4JcXpg" isDefault="1" displayUnit="l">
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+                        <Info min="0" flag="62" seq="11" ref="0" bb="2" group="124" />
+                      </Parameter>
+                      <Parameter id="itQ4HH4fHEa7eu51sPIbLw" name="pH" description="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="vNehtSpde0yreA4KgSiy2A" isDefault="1">
+                        <Tags>
+                          <Tag value="Heart" />
+                        </Tags>
+                        <Info min="0" max="14" flag="122" seq="35" ref="0" bb="32" group="84" />
+                      </Parameter>
+                      <Container id="sTlb9IduSUSGfP-6h1VA2A" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
+                        <Children>
+                          <Parameter id="v6yBRJFENECIDOtEkikULQ" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_o63arufdk2PTQFsOiSkqg" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                          </Parameter>
+                          <Parameter id="b__b5bp1uUWYgTubOjRU5Q" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="G2ThG-miOkSliCqmOXMSag" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                          </Parameter>
+                          <Parameter id="RTuzF8gQ302FXDb4ZI-xnA" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="3PTNCKfDA0yr8QD63uBncQ" isDefault="1" displayUnit="min">
+                            <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                        </Children>
+                      </Container>
+                    </Children>
+                  </Container>
+                  <Container id="w76-1ar03UKTtqfryYI_Sg" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
+                    <Tags>
+                      <Tag value="Heart" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="x9gJiVMxRUWL7jnAGQQsSQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="-ijMbq55KEWxwtKNegWm3g" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="ycKnB_lGu0qVY9E4HMV3-w" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="nGzrbq1s0U6FgEbhM3oFgQ" isDefault="1" displayUnit="l">
+                        <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                        <Info min="0" flag="62" seq="11" ref="0" bb="2" group="125" />
+                      </Parameter>
+                      <Parameter id="3fB52EXDyE2Z4H8RroIrUA" name="pH" description="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.1">
+                        <Tags>
+                          <Tag value="Heart" />
+                        </Tags>
+                        <ValueOrigin id="34" source="Publication" description="Toxicol In Vitro. 2008 Mar;22(2):457-67 https://doi.org/10.1016/j.tiv.2007.09.010" />
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+                      </Parameter>
+                      <Container id="i2sCaCKvzUurgyaoH-jv6w" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
+                        <Children>
+                          <Parameter id="hx7uqTKgE0OVW476wMBXqg" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_o63arufdk2PTQFsOiSkqg" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                          </Parameter>
+                          <Parameter id="ASYy7vJIOUa4oD6lPxvcTg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="2qkkX-OwA02AdyKzGygP4Q" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                          </Parameter>
+                          <Parameter id="njReZnawrEefeuDOisirjQ" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="3PTNCKfDA0yr8QD63uBncQ" isDefault="1" displayUnit="min">
+                            <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                        </Children>
+                      </Container>
+                    </Children>
+                  </Container>
+                </Children>
+              </Container>
+              <Container id="scXAUgb-70q2UIXEO3CYNA" name="Kidney" description="Kidney" icon="Kidney" mode="Logical" containerType="Organ">
+                <Tags>
+                  <Tag value="TissueOrgan" />
+                </Tags>
+                <Children>
+                  <Parameter id="mQ-HiB63KE-c1-1wXjVQmg" name="Weight (tissue)" description="Weight of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="wccWBS9A2kuoeEsL1_z2ww" isDefault="1" displayUnit="kg">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
+                  </Parameter>
+                  <Parameter id="IW3-FhhETE2RmPhqExxVZg" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="_1qGrWaZQ0-mf9ujtwqKng" isDefault="1" displayUnit="l/min">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
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+                    <Info min="0" flag="122" seq="12" ref="0" bb="32" group="27" />
+                  </Parameter>
+                  <Parameter id="0ijnQ13TX0i6v1O2g-WlMQ" name="Lymph flow rate" description="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="wo_Oqj188kKCGN911xCrEw" isDefault="1" displayUnit="l/min">
+                    <Tags>
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+                    </Tags>
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+                    <Info min="0" flag="122" seq="12" ref="0" bb="32" group="58" />
+                  </Parameter>
+                  <Parameter id="6vYHm6kRvkGJLvOtVPupeg" name="Volume (endothelium)" description="Volume of  vascular endothelium" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="tQrmK6cHaEWnMCyaMVxGNQ" isDefault="1" displayUnit="l">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="62" seq="12" ref="0" bb="32" group="127" />
+                  </Parameter>
+                  <Parameter id="TpsCgGHFy0OJdsHXr9OqIQ" name="Fraction intracellular" description="Fraction of intracellular space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ZxHXV_JusU-NQSlrOekb3w" isDefault="1">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="62" seq="37" ref="0" bb="32" group="64" />
+                  </Parameter>
+                  <Parameter id="Q6g8gGDndUG1DtTck4xIZw" name="GFR" description="Glomerular filtration rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="k-IWP-ene02mzK9qaaAAVA" isDefault="1" displayUnit="ml/min">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="60" seq="99" ref="0" bb="32" group="30" />
+                  </Parameter>
+                  <Parameter id="ZHMl5QSWtUebAcmEwm0hlQ" name="GFR (specific)" description="Glomerular filtration rate normalized to the volume of the kidney" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" formula="zjecs4om0E6x4-kVJbZp-Q" isDefault="1" displayUnit="ml/min/100g organ">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="15" source="Publication" description="Schlender J-F, Meyer M, et al. Development of a Whole-Body Physiologically Based Pharmacokinetic Approach to Assess the Pharmacokinetics of Drugs in Elderly Individuals. Clinical Pharmacokinetics. 2016;55(12):1573-1589. doi:10.1007/s40262-016-0422-3" />
+                    <Info min="0" flag="122" seq="99" ref="0" bb="32" group="30" />
+                  </Parameter>
+                  <Parameter id="m-Ff_9uXYUuyBBtQA-Caiw" name="Renal aging scaling factor" description="Defines the aging rate for renal elimination processes based on the kidney size dependence" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="bDf_LjDDMkO3KFD3Oj6R7g" isDefault="1">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="52" seq="99" ref="0" bb="32" group="30" />
+                  </Parameter>
+                  <Parameter id="r9qonYEBkEORR2DwRR9UKw" name="Blood flow rate" description="Organ blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="kOPtX3xlRUyjlOOtEoP9Yg" isDefault="1" displayUnit="l/min">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="48" source="Other" description="Absolute value = specific value (i.e. value normalized to the volume of the organ) multiplied by the organ volume" />
+                    <Info min="0" flag="62" seq="102" ref="0" bb="32" group="5" />
+                  </Parameter>
+                  <Parameter id="P3Wo7ikiQ0-VVZp6hZ35vA" name="Density (tissue)" description="Density of tissue" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="38" seq="1" ref="0" bb="32" group="21" />
+                  </Parameter>
+                  <Parameter id="NtqjgmrrDUCEQ7ck-7Ri_w" name="Fluid recirculation flow proportionality factor" description="proportionality factor linking fluid recirculation flow to lymph flow via small pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.761">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="27" />
+                  </Parameter>
+                  <Parameter id="swTb5icXBkq63ryiqYgkeA" name="Lymph flow proportionality factor" description="Proportionality factor linking lymph flow to plasma flow" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.000709">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="58" />
+                  </Parameter>
+                  <Parameter id="EhROuCSmbky3s07J_MERng" name="Organ volume mouse" description="Organ volume mouse" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.00034" displayUnit="l">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="65" />
+                  </Parameter>
+                  <Parameter id="31w9BVb0uUW3su_Co2NhIw" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.75">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0.75" max="0.75" flag="54" seq="1" ref="0" bb="32" group="2" />
+                  </Parameter>
+                  <Parameter id="aE5T_Z6BtESfwU2mchb6Qg" name="Volume (standard kidney)" description="Volume (standard kidney)" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.44" displayUnit="l">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="52" seq="1" ref="0" bb="32" group="6" />
+                  </Parameter>
+                  <Parameter id="qN_v2OQUykW586otLk-k5Q" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="54" seq="1" ref="0" bb="32" group="94" />
+                  </Parameter>
+                  <Parameter id="2REh0sLBmkeReG-_ZXxF5g" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.05">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" max="1" flag="122" seq="12" ref="0" bb="32" group="114" />
+                  </Parameter>
+                  <Parameter id="uD0tAzenTkugwNZBLRx3lA" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" icon="Parameter" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.25E-10" displayUnit="ml/min/N">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="12" ref="0" bb="32" group="115" />
+                  </Parameter>
+                  <Parameter id="7Tyh_LlBmUOKS_h_5ua5tA" name="Radius (large pores)" description="Large endothelial pores radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.5E-07" displayUnit="µm">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="12" ref="0" bb="32" group="55" />
+                  </Parameter>
+                  <Parameter id="00VtnUqjB06BgCkV3Om0fQ" name="Radius (small pores)" description="Small endothelial pores radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="4.5E-08" displayUnit="µm">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="12" ref="0" bb="32" group="99" />
+                  </Parameter>
+                  <Parameter id="QmmboYTIBUi4aD0piG5DUA" name="Fraction vascular" description="Fraction of vascular space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.23">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="40" source="Publication" description="Edginton, A.N., Schmitt, W. &amp; Willmann, S. Clin Pharmacokinet (2006) 45: 1013. https://doi.org/10.2165/00003088-200645100-00005" />
+                    <Info min="0" max="1" flag="62" seq="36" ref="0" bb="32" group="64" />
+                  </Parameter>
+                  <Parameter id="h5gYb0HRbkSDHz5Mi_RViw" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.052">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
+                    <Info min="0" max="1" flag="122" seq="36" ref="0" bb="32" group="85" />
+                  </Parameter>
+                  <Parameter id="O6YDfRTcHkSzLX2lgmlenA" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0207">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="36" ref="0" bb="32" group="86" />
+                  </Parameter>
+                  <Parameter id="FffNMVu7kEe324OE2VRhtQ" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0162">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="37" ref="0" bb="32" group="86" />
+                  </Parameter>
+                  <Parameter id="dgmEd1rfeEm-pk_XMiF3bw" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.171">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
+                    <Info min="0" max="1" flag="122" seq="37" ref="0" bb="32" group="85" />
+                  </Parameter>
+                  <Parameter id="OaE3OHm7T0iuMLyk3dcLFQ" name="Fraction interstitial" description="Fraction of interstitial space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.2">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="19" source="Publication" description="Kawai R, Lemaire M, Steimer JL, Bruelisauer A, Niederberger W, Rowland M. Physiologically based pharmacokinetic study on a cyclosporin derivative, SDZ IMM 125. J Pharmacokinet Biopharm. 1994 Oct;22(5):327-65." />
+                    <Info min="0" max="1" flag="62" seq="38" ref="0" bb="32" group="64" />
+                  </Parameter>
+                  <Parameter id="1LJEmLQc8EaE6oQGImEnOQ" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.13">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="22" source="Publication" description="Rodgers T, Rowland M. Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J Pharm Sci. 2006 Jun;95(6):1238-57 https://doi.org/10.1002/jps.20502" />
+                    <Info min="0" max="1" flag="122" seq="38" ref="0" bb="32" group="111" />
+                  </Parameter>
+                  <Parameter id="s-teX1N8g0y5sEqraRA9Mw" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="24" source="Publication" description="POULIN P, THEIL F. Prediction of Pharmacokinetics Prior to In Vivo Studies. 1. Mechanism-Based Prediction of Volume of Distribution. JOURNAL OF PHARMACEUTICAL SCIENCES, VOL. 91, NO. 1, JANUARY 2002" />
+                    <Info min="0" max="1" flag="122" seq="38" ref="0" bb="32" group="112" />
+                  </Parameter>
+                  <Parameter id="GArNKcVXhkeW_Ak1h4bDpA" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.137">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="22" source="Publication" description="Rodgers T, Rowland M. Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J Pharm Sci. 2006 Jun;95(6):1238-57 https://doi.org/10.1002/jps.20502" />
+                    <Info min="0" max="1" flag="122" seq="38" ref="0" bb="32" group="113" />
+                  </Parameter>
+                  <Parameter id="fxYFegRY1kOcR3PKSyS5DA" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.774">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
+                    <Info min="0" max="1" flag="122" seq="38" ref="0" bb="32" group="85" />
+                  </Parameter>
+                  <Parameter id="PDniboRGzk6aHCfrikw5iw" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.783">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="38" ref="0" bb="32" group="86" />
+                  </Parameter>
+                  <Parameter id="KsszPt0pQUitg7NS9lwXVQ" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0121">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="22" source="Publication" description="Rodgers T, Rowland M. Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J Pharm Sci. 2006 Jun;95(6):1238-57 https://doi.org/10.1002/jps.20502" />
+                    <Info min="0" max="1" flag="122" seq="60" ref="0" bb="32" group="92" />
+                  </Parameter>
+                  <Parameter id="KVVVdI_zeUmB4Ycw9zrjPw" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0156">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="60" ref="0" bb="32" group="95" />
+                  </Parameter>
+                  <Parameter id="ydA2g5le4Uet0qq_XVqUsg" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.024">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="22" source="Publication" description="Rodgers T, Rowland M. Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J Pharm Sci. 2006 Jun;95(6):1238-57 https://doi.org/10.1002/jps.20502" />
+                    <Info min="0" max="1" flag="122" seq="61" ref="0" bb="32" group="92" />
+                  </Parameter>
+                  <Parameter id="hRvfQDyUc0m0EsNil2PWyQ" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0366">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="61" ref="0" bb="32" group="95" />
+                  </Parameter>
+                  <Parameter id="o0aoIGisg028bkiOgBSUOg" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.273">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="21" source="Publication" description="Rodgers T, Leahy D, Rowland M. Physiologically based pharmacokinetic modeling 1: predicting the tissue distribution of moderate-to-strong bases. J Pharm Sci. 2005 Jun;94(6):1259-76. https://doi.org/10.1002/jps.20322" />
+                    <Info min="0" max="1" flag="122" seq="62" ref="0" bb="32" group="92" />
+                  </Parameter>
+                  <Parameter id="UkbDZMmHUU2v2fw3-FPy9g" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.21">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="62" ref="0" bb="32" group="95" />
+                  </Parameter>
+                  <Parameter id="DLVb6WereEC_VcidKWGmZg" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.399">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="22" source="Publication" description="Rodgers T, Rowland M. Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J Pharm Sci. 2006 Jun;95(6):1238-57 https://doi.org/10.1002/jps.20502" />
+                    <Info min="0" max="1" flag="122" seq="63" ref="0" bb="32" group="92" />
+                  </Parameter>
+                  <Parameter id="p2haRspjzkGjVwhJ-Qgdww" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.73">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="63" ref="0" bb="32" group="95" />
+                  </Parameter>
+                  <Parameter id="qpWbsvWGt0umAHDQsgXRZQ" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="5.03">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="21" source="Publication" description="Rodgers T, Leahy D, Rowland M. Physiologically based pharmacokinetic modeling 1: predicting the tissue distribution of moderate-to-strong bases. J Pharm Sci. 2005 Jun;94(6):1259-76. https://doi.org/10.1002/jps.20322" />
+                    <Info min="0" max="1000" flag="122" seq="64" ref="0" bb="32" group="92" />
+                  </Parameter>
+                  <Parameter id="8Hg1myTZ-kms0ABKDykP1A" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0078">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="64" ref="0" bb="32" group="95" />
+                  </Parameter>
+                  <Parameter id="OkOC69_BZkurEWZmiMEZ1g" name="fGFRpremat" description="Fractional offset in the GFR that corrects for a tendency to slightly underestimate the observed median GFR values in preterm infants below approximately 32 weeks of gestation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.258">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="27" source="Publication" description="Claassen K, Thelen K, Coboeken K, Gaub T, Lippert J, Allegaert K, Willmann S. Development of a Physiologically-Based Pharmacokinetic Model for Preterm Neonates: Evaluation with In Vivo Data. Current Pharmaceutical Design, 2015, 21, 5688-5698" />
+                    <Info min="0.258" max="0.258" flag="54" seq="99" ref="0" bb="32" group="30" />
+                  </Parameter>
+                  <DistributedParameter id="OuWq-92uCEWu6Bf06nLxjg" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="jfbg24q4JUiepcWVu2cpMw" mode="Logical" isDefault="1" displayUnit="l">
+                    <Children>
+                      <Parameter id="ajPaRk_Adk2DykQpLcNEjA" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.503084571851831">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="65" />
+                      </Parameter>
+                      <Parameter id="ROfHVErPJ06qcy2UbKVhyQ" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.43771998528" displayUnit="l">
+                        <Info min="0" flag="34" seq="1" ref="0" bb="32" group="65" />
+                      </Parameter>
+                      <Parameter id="Pa8-L288_0SSUUCd1SvVoQ" name="Deviation" description="Standard deviation of Normal distribution" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.107804039048952" displayUnit="l">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="65" />
+                      </Parameter>
+                    </Children>
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
+                    <Info min="0" flag="106" seq="7" ref="0" bb="32" group="65" />
+                  </DistributedParameter>
+                  <DistributedParameter id="JFNMZ7cCu0iE74ENCncppQ" name="Age of aging onset" description="Sets the start age for aging processes" persistable="0" isFixedValue="0" dim="Age in years" quantityType="Parameter" negativeValuesAllowed="1" formula="dwduEhkOOEO5LwcrGqma9A" mode="Logical" isDefault="1" displayUnit="year(s)">
+                    <Children>
+                      <Parameter id="EwNhslKNkU2ob7jPpuQRwg" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="30" />
+                      </Parameter>
+                      <Parameter id="bAlZirIeb0aQwMTjSZEuHA" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Age in years" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="30" displayUnit="year(s)">
+                        <Info min="30" max="30" flag="50" seq="1" ref="0" bb="32" group="30" />
+                      </Parameter>
+                    </Children>
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="15" source="Publication" description="Schlender J-F, Meyer M, et al. Development of a Whole-Body Physiologically Based Pharmacokinetic Approach to Assess the Pharmacokinetics of Drugs in Elderly Individuals. Clinical Pharmacokinetics. 2016;55(12):1573-1589. doi:10.1007/s40262-016-0422-3" />
+                    <Info min="30" max="30" flag="54" seq="99" ref="0" bb="32" group="30" />
+                  </DistributedParameter>
+                  <DistributedParameter id="zhT9W1lk706aypGJCnpcDg" name="Aging half-time" description="Describes the age where the specific GFR reduction is half way decreased" persistable="0" isFixedValue="0" dim="Age in years" quantityType="Parameter" negativeValuesAllowed="1" formula="gsy3NmY1QEa71hejURx65A" mode="Logical" isDefault="1" displayUnit="year(s)">
+                    <Children>
+                      <Parameter id="vcABH1HKsUi_elVc9fkpSw" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="30" />
+                      </Parameter>
+                      <Parameter id="wCrlablZa0m47WtJ-J2Bvg" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Age in years" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="54" displayUnit="year(s)">
+                        <Info min="30" max="100" flag="50" seq="1" ref="0" bb="32" group="30" />
+                      </Parameter>
+                    </Children>
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="15" source="Publication" description="Schlender J-F, Meyer M, et al. Development of a Whole-Body Physiologically Based Pharmacokinetic Approach to Assess the Pharmacokinetics of Drugs in Elderly Individuals. Clinical Pharmacokinetics. 2016;55(12):1573-1589. doi:10.1007/s40262-016-0422-3" />
+                    <Info min="30" max="100" flag="54" seq="99" ref="0" bb="32" group="30" />
+                  </DistributedParameter>
+                  <DistributedParameter id="dnhfvEjHRUKGzh5oMZcQhw" name="GFRmat" description="Mature value for GFR in a healthy adult individual weighing 70 kg (=117 mL/min)" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="qsccsT_UQU63VNizoqFF-w" mode="Logical" isDefault="1" displayUnit="l/min">
+                    <Children>
+                      <Parameter id="Q3FFqUn61UiiE7SOcWiP_A" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="30" />
+                      </Parameter>
+                      <Parameter id="kT-F1yphG0CudZF2sAJJhg" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.11704" displayUnit="l/min">
+                        <Info min="0" flag="50" seq="1" ref="0" bb="32" group="30" />
+                      </Parameter>
+                      <Parameter id="YCPJi50wtk6NwnSUN1Mycw" name="Deviation" description="Standard deviation of Normal distribution" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.026708" displayUnit="l/min">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="30" />
+                      </Parameter>
+                    </Children>
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="27" source="Publication" description="Claassen K, Thelen K, Coboeken K, Gaub T, Lippert J, Allegaert K, Willmann S. Development of a Physiologically-Based Pharmacokinetic Model for Preterm Neonates: Evaluation with In Vivo Data. Current Pharmaceutical Design, 2015, 21, 5688-5698" />
+                    <Info min="0" flag="54" seq="99" ref="0" bb="32" group="30" />
+                  </DistributedParameter>
+                  <DistributedParameter id="-ddITgcGwEenq7dxKg97Ug" name="Hill coefficient for aging GFR" description="Parameter informing the exponential reduction of the aging GFR" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="S-8QwodHHEa9wWXtPXJicQ" mode="Logical" isDefault="1">
+                    <Children>
+                      <Parameter id="ZxYIN8jNqE6tHL4iiyb3Ig" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="30" />
+                      </Parameter>
+                      <Parameter id="ARi0EQzz1kqdYBncaP4khw" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.5">
+                        <Info min="0" flag="34" seq="1" ref="0" bb="32" group="30" />
+                      </Parameter>
+                    </Children>
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="15" source="Publication" description="Schlender J-F, Meyer M, et al. Development of a Whole-Body Physiologically Based Pharmacokinetic Approach to Assess the Pharmacokinetics of Drugs in Elderly Individuals. Clinical Pharmacokinetics. 2016;55(12):1573-1589. doi:10.1007/s40262-016-0422-3" />
+                    <Info min="0" flag="38" seq="99" ref="0" bb="32" group="30" />
+                  </DistributedParameter>
+                  <DistributedParameter id="BCJXZPdY3U6CIn8OQrkpPQ" name="Hill coefficient for GFR" description="Parameter describing the cooperativity of the process for GFR calculation" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TdI_gPhw10OKcoa8P3v5KQ" mode="Logical" isDefault="1">
+                    <Children>
+                      <Parameter id="jpWM6j5xtUyncYhjXYrstg" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="30" />
+                      </Parameter>
+                      <Parameter id="UQpZfMhNg0iJpZW61pUqVw" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="15">
+                        <Info min="1" flag="50" seq="1" ref="0" bb="32" group="30" />
+                      </Parameter>
+                      <Parameter id="otVPeDf-vkerdSoMQG_JZw" name="Deviation" description="Standard deviation of Normal distribution" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.257">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="30" />
+                      </Parameter>
+                    </Children>
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="27" source="Publication" description="Claassen K, Thelen K, Coboeken K, Gaub T, Lippert J, Allegaert K, Willmann S. Development of a Physiologically-Based Pharmacokinetic Model for Preterm Neonates: Evaluation with In Vivo Data. Current Pharmaceutical Design, 2015, 21, 5688-5698" />
+                    <Info min="1" flag="54" seq="99" ref="0" bb="32" group="30" />
+                  </DistributedParameter>
+                  <DistributedParameter id="tkdZy0F0w0KA6qazh-THJw" name="Maximal decreasing rate factor" description="Parameter describes the maximal decreasing rate per year of age" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BMbu3xOsjU6t-b3u387EsQ" mode="Logical" isDefault="1">
+                    <Children>
+                      <Parameter id="ekzKfZLM2UiGurPrhVo52A" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="30" />
+                      </Parameter>
+                      <Parameter id="01ILuQaQfkmArpI78HKi1Q" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.9">
+                        <Info min="0" flag="50" seq="1" ref="0" bb="32" group="30" />
+                      </Parameter>
+                    </Children>
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="15" source="Publication" description="Schlender J-F, Meyer M, et al. Development of a Whole-Body Physiologically Based Pharmacokinetic Approach to Assess the Pharmacokinetics of Drugs in Elderly Individuals. Clinical Pharmacokinetics. 2016;55(12):1573-1589. doi:10.1007/s40262-016-0422-3" />
+                    <Info min="0" flag="54" seq="99" ref="0" bb="32" group="30" />
+                  </DistributedParameter>
+                  <DistributedParameter id="xQt4JLG7RUitFCo2a_WOAw" name="TM50 for GFR" description="TM50 for GFR calculation" persistable="0" isFixedValue="0" dim="Age in weeks" quantityType="Parameter" negativeValuesAllowed="1" formula="hlDzCHtmaUqGQ8ddptW-Tw" mode="Logical" isDefault="1" displayUnit="week(s)">
+                    <Children>
+                      <Parameter id="Ry_9MclecES5RnFp6fT5Vw" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="30" />
+                      </Parameter>
+                      <Parameter id="24n-a8oyXUiF5G-3XQqj-g" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Age in weeks" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="44.4" displayUnit="week(s)">
+                        <Info min="1" flag="50" seq="1" ref="0" bb="32" group="30" />
+                      </Parameter>
+                      <Parameter id="O_hxwVoZOkOUnIQtSTH82g" name="Deviation" description="Standard deviation of Normal distribution" icon="Parameter" persistable="0" isFixedValue="0" dim="Age in weeks" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.04" displayUnit="week(s)">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="30" />
+                      </Parameter>
+                    </Children>
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="27" source="Publication" description="Claassen K, Thelen K, Coboeken K, Gaub T, Lippert J, Allegaert K, Willmann S. Development of a Physiologically-Based Pharmacokinetic Model for Preterm Neonates: Evaluation with In Vivo Data. Current Pharmaceutical Design, 2015, 21, 5688-5698" />
+                    <Info min="1" flag="54" seq="99" ref="0" bb="32" group="30" />
+                  </DistributedParameter>
+                  <DistributedParameter id="oPf27f8EEEiyoQJ67FHCVw" name="Specific blood flow rate" description="Blood flow rate normalized to the organ volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" formula="a9WY-bVpAUWD-I4T67IF7Q" mode="Logical" isDefault="1" displayUnit="ml/min/100g organ">
+                    <Children>
+                      <Parameter id="cJ0GUk1XekCy-Tt4e-YQmQ" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="5" />
+                      </Parameter>
+                      <Parameter id="cJW6YHGXY0qfH8s5AdGwBQ" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="3.02705" displayUnit="ml/min/100g organ">
+                        <Info min="0" flag="50" seq="1" ref="0" bb="32" group="5" />
+                      </Parameter>
+                      <Parameter id="gYqbW5pIhkCWyHwtgGCcIg" name="Deviation" description="Standard deviation of Normal distribution" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.1513525" displayUnit="ml/min/100g organ">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="5" />
+                      </Parameter>
+                    </Children>
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="40" source="Publication" description="Edginton, A.N., Schmitt, W. &amp; Willmann, S. Clin Pharmacokinet (2006) 45: 1013. https://doi.org/10.2165/00003088-200645100-00005" />
+                    <Info min="0" flag="122" seq="101" ref="0" bb="32" group="5" />
+                  </DistributedParameter>
+                  <Container id="g0ppnZPQBkqwKVu3lsxWKw" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
+                    <Tags>
+                      <Tag value="Kidney" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="mOTmNmb1nUKwmx7IF9cPmw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="jUuicTjwYECqpkpEHOcv6w" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="WNrIq-Nga06bddkSXDG4lQ" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="2ErPZJcYvUyL3QogRRKmZg" isDefault="1" displayUnit="l">
+                        <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                        <Info min="0" flag="62" seq="12" ref="0" bb="2" group="126" />
+                      </Parameter>
+                      <Container id="aRIyzTGKHkOyz9AYexjoHg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
+                        <Children>
+                          <Parameter id="2S-ZGsQ_gEyCy2WTEjilLw" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_o63arufdk2PTQFsOiSkqg" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                          </Parameter>
+                          <Parameter id="l40j0myK6UWl0WYOSjKwQg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="pDRD-WocckCSQtVxG1Keug" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                          </Parameter>
+                          <Parameter id="FQjjlJH_G0W8B5nVLz0Sdg" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="3PTNCKfDA0yr8QD63uBncQ" isDefault="1" displayUnit="min">
+                            <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                        </Children>
+                      </Container>
+                    </Children>
+                  </Container>
+                  <Container id="fpo7n9IKhEKtWLMWgD88GQ" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
+                    <Tags>
+                      <Tag value="Kidney" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="ZJajNooYskWTy0E46vE1JQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="jUuicTjwYECqpkpEHOcv6w" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="q91K2wKh00KNlAX46_hJRA" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="V2_FdO3puUGekuCdqn4lGg" isDefault="1" displayUnit="l">
+                        <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                        <Info min="0" flag="62" seq="12" ref="0" bb="2" group="121" />
+                      </Parameter>
+                      <Container id="sSeTow4li0-ASYDIHPKP1Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
+                        <Children>
+                          <Parameter id="h1LU9ytJLU-F7HoSncsvLA" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_o63arufdk2PTQFsOiSkqg" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                          </Parameter>
+                          <Parameter id="6pktCrFHIku0SF9OImMyvA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_B4r1Pf9BEa0ce4IJUo7mA" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                          </Parameter>
+                          <Parameter id="Qkc6mgFpEUmLye00lvGn_g" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="3PTNCKfDA0yr8QD63uBncQ" isDefault="1" displayUnit="min">
+                            <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                        </Children>
+                      </Container>
+                    </Children>
+                  </Container>
+                  <Container id="80QMPHaFAUOAEMdImEADzw" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
+                    <Tags>
+                      <Tag value="Kidney" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="SdpOg2VSi02K-jcop9W11g" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="jUuicTjwYECqpkpEHOcv6w" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="NHS50LqHU0WaftIddLg33Q" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="FsvYOeKl5kaJQ1JZ4JcXpg" isDefault="1" displayUnit="l">
+                        <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                        <Info min="0" flag="62" seq="12" ref="0" bb="2" group="124" />
+                      </Parameter>
+                      <Parameter id="vgvyRfjOckSRYm5vNF7HLQ" name="pH" description="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="vNehtSpde0yreA4KgSiy2A" isDefault="1">
+                        <Tags>
+                          <Tag value="Kidney" />
+                        </Tags>
+                        <Info min="0" max="14" flag="122" seq="38" ref="0" bb="32" group="84" />
+                      </Parameter>
+                      <Container id="FvoWY-h-PkKa2EDTBDo-NA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
+                        <Children>
+                          <Parameter id="iaCTVf4IkE2dGzDROyfDrA" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_o63arufdk2PTQFsOiSkqg" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                          </Parameter>
+                          <Parameter id="TEoY1-VFwUmY78xC3iGykw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="oDTXqqzLWEWj6dQ3AqYGIQ" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                          </Parameter>
+                          <Parameter id="tyBVb1-MJ0O8uO3tTehr6Q" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="3PTNCKfDA0yr8QD63uBncQ" isDefault="1" displayUnit="min">
+                            <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                        </Children>
+                      </Container>
+                    </Children>
+                  </Container>
+                  <Container id="CUgealQGGUa_yk3fJucd5w" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
+                    <Tags>
+                      <Tag value="Kidney" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="QvJNcYP0ZE-K3mwJYq1L-A" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="-ijMbq55KEWxwtKNegWm3g" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="tCIvzq7EQkW4vDAV58CGJA" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="nGzrbq1s0U6FgEbhM3oFgQ" isDefault="1" displayUnit="l">
+                        <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                        <Info min="0" flag="62" seq="12" ref="0" bb="2" group="125" />
+                      </Parameter>
+                      <Parameter id="CTVioLDxvEi6VAmttSLZCQ" name="pH" description="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.22">
+                        <Tags>
+                          <Tag value="Kidney" />
+                        </Tags>
+                        <ValueOrigin id="34" source="Publication" description="Toxicol In Vitro. 2008 Mar;22(2):457-67 https://doi.org/10.1016/j.tiv.2007.09.010" />
+                        <Info min="0" max="14" flag="122" seq="38" ref="0" bb="32" group="83" />
+                      </Parameter>
+                      <Container id="w4exSzOFVkWvSuy9o6xnsQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
+                        <Children>
+                          <Parameter id="cTcsSRgjDkatREGH8TkS0Q" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_o63arufdk2PTQFsOiSkqg" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                          </Parameter>
+                          <Parameter id="0-5ofo_V9UWYyE8sfweKFw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="OH1RKadKc06EkAg9VpDXXQ" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                          </Parameter>
+                          <Parameter id="cyJojNofUUiVGqZPtYSZhA" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="3PTNCKfDA0yr8QD63uBncQ" isDefault="1" displayUnit="min">
+                            <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                        </Children>
+                      </Container>
+                    </Children>
+                  </Container>
+                  <Container id="iW_tZ2dDfEmYSkQBNj57aQ" name="Urine" description="Urine compartment used to collect the fraction excreted to urine" mode="Physical" containerType="Compartment">
+                    <Tags>
+                      <Tag value="Kidney" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="P4NUiYL7c0iCxnQdiZavow" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="l">
+                        <Info min="0" flag="54" seq="666" ref="0" bb="2" group="65" />
+                      </Parameter>
+                      <Container id="AkTltFuk5EuTE-Ep_YAlRw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Container>
+              <Container id="6OyqPzv0L0mVIlDlQR9DrA" name="Lumen" description="Lumen" icon="Lumen" mode="Logical" containerType="Organ">
+                <Children>
+                  <Parameter id="Jk9hcnemjkumSBnSF8T8sg" name="OralApplicationsEnabled" description="Enables/disables all transports between mucosa and lumen" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                    <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="63" />
+                  </Parameter>
+                  <Parameter id="5Ay1B51Qgkmsi7EJKwC2Mw" name="Paracellular absorption sink condition" description="Flag for conditions of the environment for paracellular absorption: 1= no sink condition, 0 = sink condition" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                    <Info min="0" max="1" flag="58" seq="1" ref="0" bb="2" group="39" />
+                  </Parameter>
+                  <Parameter id="iiYxTHtYw0SqzsWx6F9lPQ" name="Transcellular absorption sink condition" description="Flag for conditions of the environment for transcellular absorption: 1=no sink condition, 0=sink condition" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                    <Info min="0" max="1" flag="58" seq="1" ref="0" bb="2" group="39" />
+                  </Parameter>
+                  <DistributedParameter id="DDOHSo5OXkq5ceMDSOz0fw" name="Effective surface area variability factor" description="Effective surface area variability factor" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="hS8Y61jeNU6PISiRwqrylA" mode="Logical" isDefault="1">
+                    <Children>
+                      <Parameter id="HRHJOuycTk-pWfyXz3NW5Q" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="144" />
+                      </Parameter>
+                      <Parameter id="JL0zFoGJ0kq8iE-A5zHDRg" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                        <Info min="0" flag="34" seq="1" ref="0" bb="32" group="144" />
+                      </Parameter>
+                      <Parameter id="cAkwDD40L0O5X1gG-KIGhA" name="GeometricDeviation" description="Geometric standard deviation of LogNormal distribution" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.6">
+                        <Info min="1" flag="18" seq="1" ref="0" bb="32" group="144" />
+                      </Parameter>
+                    </Children>
+                    <Info min="0" flag="106" seq="1" ref="0" bb="32" group="144" />
+                  </DistributedParameter>
+                  <Container id="x_RtXB5WrkSeYcZWpjSEKA" name="Stomach" description="Stomach" icon="Stomach" mode="Physical" containerType="Compartment">
+                    <Tags>
+                      <Tag value="Lumen" />
+                      <Tag value="LumenSegment" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="zB0AKI0JKEu2DRtyvSsjfQ" name="Absorption of liquid" description="rate of liquid outflow" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0" displayUnit="1/min">
+                        <Info flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="0ovUgnRdW0mNp_VDHKuDKw" name="FillLevelFlag" description="Fill Level Flag" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="7HeksdzzjUeQj7kX8vDHbg" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="uZ3CjOzGu0GjP1dzcbvm1w" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="1idWGEaDeE2qn5k830utxA" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="uzRcurygQEKgmancpQt0CQ" name="Geometric surface area" description="Geometric surface area of GI segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="c4Zv_ty3ZEOIEkFTsiKx8A" isDefault="1" displayUnit="cm²">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="62" seq="1" ref="0" bb="32" group="33" />
+                      </Parameter>
+                      <Parameter id="2K-7jZ48_0OEB46gZf5hiw" name="GET of non-disintegrated moiety" description="The time point at which a solid dosage leaves the stomach and enters the duodenum. Please note that the discrete emptying of a solid dosage form depends on both the physiological properties of the individual and the dosage form." icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="60" displayUnit="min">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="39" />
+                      </Parameter>
+                      <Parameter id="4z_pm57KFEKgQPRlouvt0Q" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Myfy1bCLN0e5XhzYuHVojA" isDefault="1" displayUnit="1/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="UHy9byUssES3YpebcRbohQ" name="Liquid" description="Liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="N0wzZBKIDkiUKbOSRMr88w" isDefault="1" rHSFormula="sVSG0yebgEaPjr2hFT7fpg" displayUnit="l">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="sGIp3BsYEUGyk2dzPZTaxQ" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="ZjtYE6Afe025Qxrr-Xpc4w" isDefault="1" displayUnit="l/min">
+                        <Info flag="52" seq="1" ref="0" bb="2" group="39" />
+                      </Parameter>
+                      <Parameter id="LMFWcmPPnkGr_X5kPbU1Aw" name="pH" description="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="jrEXErubXUaiDzmrIt6FUQ" isDefault="1">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" max="14" flag="52" seq="1" ref="0" bb="32" group="41" />
+                      </Parameter>
+                      <Parameter id="e1bJJxgLo0KsY8k3joZMfw" name="Secretion of liquid" description="Rate of liquid inflow" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="97T2B-AfCkeD4Mbijl-6og" isDefault="1" displayUnit="l/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="pGyvAKTFxkG2ntO7Fhq8Ig" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="WpAy5WPuG0WjdRWkmGKlHA" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="62" seq="1" ref="0" bb="2" group="56" />
+                      </Parameter>
+                      <Parameter id="rYwMbwYOpEuAxnhluomgjA" name="Volume (gut wall)" description="Volume of the gut wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="6MpHobl9jEOg7NwC02cMmg" isDefault="1" displayUnit="l">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="62" seq="1" ref="0" bb="32" group="44" />
+                      </Parameter>
+                      <Parameter id="V8urVyaCL0KwgPdlrVInug" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="jUuicTjwYECqpkpEHOcv6w" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="rex8UOHhCkqgSRTVpYjwmw" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.030169">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="58" seq="1" ref="0" bb="32" group="43" />
+                      </Parameter>
+                      <Parameter id="8uQ7mT-2lU25wMoVrSMgng" name="pH in fed state" description="pH in fed state" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="5.5">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" max="14" flag="52" seq="1" ref="0" bb="32" group="41" />
+                      </Parameter>
+                      <Parameter id="LrM5mkO3wU6rXIV1ofi5pw" name="Thickness of gut wall" description="Thickness of Gut Wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.022668" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="54" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <Parameter id="fZeZE5pSLEeW614fdodavQ" name="Inverse rate of inflow of liquid into stomach" description="Inverse rate of inflow of liquid into stomach" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="15" displayUnit="min">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="1" max="10000" flag="54" seq="1" ref="0" bb="32" group="46" />
+                      </Parameter>
+                      <Parameter id="y0T3ZdGDykW39ZfamS4ORw" name="pH in fasted state" description="pH in fasted state" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <ValueOrigin id="25" source="Publication" description="Stefan Willmann, Walter Schmitt,Jörg Keldenich, Jörg Lippert, and Jennifer B. Dressman: A Physiological Model for the Estimation of the Fraction Dose Absorbed in Humans. J. Med. Chem. 2004, 47, 4022-4031" />
+                        <Info min="0" max="14" flag="122" seq="1" ref="0" bb="32" group="41" />
+                      </Parameter>
+                      <DistributedParameter id="ccHbv5VnMkqEz8SkHhcNog" name="Distal radius" description="Distal radius of intestinal segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="RELiHZO1f02T_oD1rHzb1Q" mode="Logical" isDefault="1" displayUnit="cm">
+                        <Children>
+                          <Parameter id="9ur8QWoIOkysCQMnREkHNA" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="32" group="35" />
+                          </Parameter>
+                          <Parameter id="QjVtpLmvo0m-wxGxqm4ypw" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5" displayUnit="cm">
+                            <Info min="0" flag="50" seq="1" ref="0" bb="32" group="35" />
+                          </Parameter>
+                        </Children>
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="122" seq="1" ref="0" bb="32" group="35" />
+                      </DistributedParameter>
+                      <DistributedParameter id="XhTNxHg6o06ZYuPAUOECcw" name="Gastric emptying time" description="The time at which the (1-1/e)th part (approximately 63%) of the applied dose (fasted state) is released from the stomach into the duodenum according to a first order process. Please note that in the case that a meal is co-administered with the drug, the gastric emptying rate is described using a Weibull function. The parameters of the Weibull function and, thus, the gastric emptying time, then depend on the volume and composition of the meal" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="rqEHjlG8-0y6pRW7RYD7Xg" mode="Logical" isDefault="1" displayUnit="min">
+                        <Children>
+                          <Parameter id="hADleuwJ00-7S48R1YF8Yg" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="32" group="46" />
+                          </Parameter>
+                          <Parameter id="4mlGEUhUMkiFqH95jyFFqA" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="15" displayUnit="min">
+                            <Info min="1" max="10000" flag="50" seq="1" ref="0" bb="32" group="46" />
+                          </Parameter>
+                          <Parameter id="DDrE4Ej7E02TwuzML2pvqQ" name="GeometricDeviation" description="Geometric standard deviation of LogNormal distribution" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.6">
+                            <Info min="1" flag="18" seq="1" ref="0" bb="32" group="46" />
+                          </Parameter>
+                        </Children>
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="1" max="10000" flag="122" seq="1" ref="0" bb="32" group="46" />
+                      </DistributedParameter>
+                      <DistributedParameter id="8vDKjRaeCkOB3A2mglIXUQ" name="GET_alpha (Weibull function) variability factor" description="GET_alpha (Weibull function) variability factor" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="yC9D_uF84EesPTtG7-KXaw" mode="Logical" isDefault="1">
+                        <Children>
+                          <Parameter id="DPzLg7tJZk21Ez7rA-iOtw" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="32" group="46" />
+                          </Parameter>
+                          <Parameter id="i0_8DFaQukyJuV6dgnsBOw" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                            <Info min="0" flag="34" seq="1" ref="0" bb="32" group="46" />
+                          </Parameter>
+                          <Parameter id="r1-2ILYF30a1q745vOzJaA" name="GeometricDeviation" description="Geometric standard deviation of LogNormal distribution" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.74">
+                            <Info min="1" flag="18" seq="1" ref="0" bb="32" group="46" />
+                          </Parameter>
+                        </Children>
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="38" seq="1" ref="0" bb="32" group="46" />
+                      </DistributedParameter>
+                      <DistributedParameter id="zViPqz8EmUa2X2ZZW5RtXA" name="GET_beta (Weibull function) variability factor" description="GET_beta (Weibull function) variability factor" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="6VBAXgR0q0G300MgcBo5yw" mode="Logical" isDefault="1">
+                        <Children>
+                          <Parameter id="YsLyzbdy402OwzgWDscJ_Q" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="32" group="46" />
+                          </Parameter>
+                          <Parameter id="NBQ4OVmuH0av6C-woQeNDQ" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                            <Info min="0" flag="34" seq="1" ref="0" bb="32" group="46" />
+                          </Parameter>
+                          <Parameter id="8BomXQMMD02zfSynGzgoAQ" name="GeometricDeviation" description="Geometric standard deviation of LogNormal distribution" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.32">
+                            <Info min="1" flag="18" seq="1" ref="0" bb="32" group="46" />
+                          </Parameter>
+                        </Children>
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="38" seq="1" ref="0" bb="32" group="46" />
+                      </DistributedParameter>
+                      <DistributedParameter id="s-UovICo0kqHxh8yrV6TNw" name="Length" description="Length" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="6BmcqC0SYUqc8-rsSB-qJw" mode="Logical" isDefault="1" displayUnit="cm">
+                        <Children>
+                          <Parameter id="sWgGHMIY6Uul7ijcQeUVFA" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="32" group="34" />
+                          </Parameter>
+                          <Parameter id="528oiGieU0S51CredNxRkg" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2" displayUnit="cm">
+                            <Info min="0" flag="50" seq="1" ref="0" bb="32" group="34" />
+                          </Parameter>
+                        </Children>
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="122" seq="1" ref="0" bb="32" group="34" />
+                      </DistributedParameter>
+                      <DistributedParameter id="Qzh9NpkAQUOWdR3cQixwWA" name="Proximal radius" description="Proximal radius of intestinal segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="o5jQo0UVTUuGShakyWvPvw" mode="Logical" isDefault="1" displayUnit="cm">
+                        <Children>
+                          <Parameter id="zNlXur4yw0GzppIkM8WbGw" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="32" group="35" />
+                          </Parameter>
+                          <Parameter id="-_HR73Cf-UeUwVsbtERhfw" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5" displayUnit="cm">
+                            <Info min="0" flag="50" seq="1" ref="0" bb="32" group="35" />
+                          </Parameter>
+                        </Children>
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="122" seq="1" ref="0" bb="32" group="35" />
+                      </DistributedParameter>
+                      <Container id="_kJ88k7K_EK1xtMpfKfTxw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
+                        <Children>
+                          <Parameter id="WH2sG-fWWUK2J4XCo0Iiqw" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="sAgLzzcSbU-Lro2PDBo-zw" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                          </Parameter>
+                          <Parameter id="a81HQ2jFc0m27FV3nimcmg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                          </Parameter>
+                          <Parameter id="OLbqXS-QFkKAee8aObqBbw" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="pLyHG64fYUuuwJbDRsgYXQ" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="VSCwKSXrGE66N2AXqCZj8Q" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="jnFn0dVW_UuaZKn4VZQsbw" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="ZbfWkrmK8EqB1-Z6MYevgg" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IQoV9Bf6fEeClxkhrWQndA" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="2cug7oE79kas2a4QzE77TQ" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="4y77xOcuwUu3mD-0abcfTw" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="uhOHnQ09N0OsY3txbe0K4A" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="HGw1h1qmUUaU5u59svvqag" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="lqeFIQJ48EyZnpFSsigFlw" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="D-O5q7FU9kGs7Oj13xfQWQ" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="pdOPcuiRVEKyEyq4IimPEg" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="KL0CMa-gw0eRoTHybxaRuA" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="C6eZKLJuC0uxAR2HrVxd3Q" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IKKvq7FNH0WVqLL1WlK98g" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="OgY91mdMZ0yCmLBFJNLxWw" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="PTWduXcrQE6TuiaHRV7EEQ" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="BPSmEjU9r0OHbmTTl4WNDA" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cs_aXu3q5EC0C6PdBucAFw" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="fMyRAAnUGUi8b3511pSV3Q" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="mHb-SliHRUiy2nu8AVrlRg" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="ayCsUZs_Ikqj_YTt0HsufQ" name="Solubility" description="Solubility" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="iRY4N1Pqn0W2jBOrCG0ptg" isDefault="1" displayUnit="mg/l">
+                            <Info min="0" flag="122" seq="1" ref="0" bb="2" group="42" />
+                          </Parameter>
+                          <Parameter id="gCaXx23NN0-cqkckwXCDMw" name="Solubility table" description="Solubility table" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="sPp7vgPS5EaDrVIJGaPr-Q" isDefault="1" displayUnit="mg/l">
+                            <Info min="0" flag="50" seq="1" ref="0" bb="2" group="42" />
+                          </Parameter>
+                          <Parameter id="jgyW8Y5u_kmigp2e6QIWJA" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="laSZo7Mr50SoKS70JH3d2Q" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="OrzQtqxG00eEVVNkTbrNuQ" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="YQERj92sg0eOeddA3tJEnw" isDefault="1" displayUnit="min">
+                            <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="MSSjE9z7fEOmUnSSMMdQcw" name="Effective concentration in lumen" description="In case of supersaturation: molecule amount divided by liquid volume. Otherwise: Min(intestinal solubility; molecule amount divided by liquid volume)." icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="MjUWb6J9o0C-1UWLMLGCqw" isDefault="1" displayUnit="µmol/l">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="42" />
+                          </Parameter>
+                        </Children>
+                      </Container>
+                    </Children>
+                  </Container>
+                  <Container id="Uh4b9ySQo0-IEUYhzejKww" name="Duodenum" description="Duodenum" icon="Duodenum" mode="Physical" containerType="Compartment">
+                    <Tags>
+                      <Tag value="Lumen" />
+                      <Tag value="LumenSegment" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="rIlq9P0I8UeAAB7QRXwtnw" name="Absorption of liquid" description="rate of liquid outflow" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="s-m16un1jkmMcHoYY5NuQA" isDefault="1" displayUnit="1/min">
+                        <Info flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="e9FflC1vIUSL-Kqwni-iJw" name="Distal radius" description="Distal radius of intestinal segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="p-ifWBsgtkCYNe8r-x0_mQ" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="fxE9vBFhgEKBgIHvs80IYg" name="Effective surface area" description="Effective surface area of GI segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="ycPdUcIp5EKqELapSr2u-w" isDefault="1" displayUnit="cm²">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
+                        <Info min="0" flag="52" seq="1" ref="0" bb="32" group="33" />
+                      </Parameter>
+                      <Parameter id="8zj4xO1b8UqWEZ24pmeviw" name="FillLevelFlag" description="Fill Level Flag" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="7HeksdzzjUeQj7kX8vDHbg" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="jmjFWx4QVUK1zqgW6-efNw" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="1idWGEaDeE2qn5k830utxA" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="WhX3s4n5pkSxB_F_u6jE_g" name="Geometric surface area" description="Geometric surface area of GI segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="c4Zv_ty3ZEOIEkFTsiKx8A" isDefault="1" displayUnit="cm²">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="62" seq="1" ref="0" bb="32" group="33" />
+                      </Parameter>
+                      <Parameter id="pY-raJhvcEC6fV2Knm-Mzg" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="2X9DfesBjUGJCU8jcgo3mQ" isDefault="1" displayUnit="1/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="wK12wKC7OE2y8LRIcgeNZQ" name="Length" description="Length" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="-nYOr4fSp0GX3ocYyuhcOw" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="106" seq="1" ref="0" bb="32" group="34" />
+                      </Parameter>
+                      <Parameter id="mFqFDYoheUehHcWUUB8lWA" name="Liquid" description="Liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="N0wzZBKIDkiUKbOSRMr88w" isDefault="1" rHSFormula="ZeH7ljwXuk218MUlMtbKtg" displayUnit="l">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="ThehzaSgq0KKYkeav_mgCg" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="7n3OGS0uWUuF_kiHTIVzfg" isDefault="1" displayUnit="l/min">
+                        <Info flag="52" seq="1" ref="0" bb="2" group="39" />
+                      </Parameter>
+                      <Parameter id="RDitA3TXo0aGRjvtnUWu4w" name="Proximal radius" description="Proximal radius of intestinal segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="68xm_j1F_kadz1plb4Humw" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="SvO1uIHJB0aqXiYzTWLi-A" name="Secretion of liquid" description="Rate of liquid inflow" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="wg3SPt1OSUuJpoKXx5bJVg" isDefault="1" displayUnit="l/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="xKBRGNKHiEGUQYQg23Z86w" name="Thickness of gut wall" description="Thickness of Gut Wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Zhmtbn4PVkKNtMUGll4olg" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="38" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <Parameter id="0UW-VJ_b_0W2G3QZmNhC0w" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="WpAy5WPuG0WjdRWkmGKlHA" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="62" seq="1" ref="0" bb="2" group="56" />
+                      </Parameter>
+                      <Parameter id="ZHj4nynQP0GC2ffl4iFARQ" name="Volume (gut wall)" description="Volume of the gut wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="4ckdHAFjsEq4hAtf7Vo77w" isDefault="1" displayUnit="l">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="62" seq="1" ref="0" bb="32" group="44" />
+                      </Parameter>
+                      <Parameter id="RLV6P51N6k6wJOGQHiC8yA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="jUuicTjwYECqpkpEHOcv6w" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="ov_d1-GrEUqWKSFYNUMz8g" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.06">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="58" seq="1" ref="0" bb="32" group="43" />
+                      </Parameter>
+                      <Parameter id="BLXHPRXJT0K_qFjkZuftDQ" name="Intestinal transit rate" description="Transit rate along intestinal segments" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="116" displayUnit="1/min">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="54" seq="1" ref="0" bb="32" group="46" />
+                      </Parameter>
+                      <Parameter id="SKyyca2sLUC8V_x_C7nn8w" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0289872252" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="34" />
+                      </Parameter>
+                      <Parameter id="EzhewbpibEavv5y-c14viQ" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.129622362">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="34" />
+                      </Parameter>
+                      <Parameter id="XpTfMJKdekWQtBvQR7dVjw" name="Microvilli factor" description="Microvilli factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="25">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="38" seq="1" ref="0" bb="32" group="33" />
+                      </Parameter>
+                      <Parameter id="1qvgfUp23kmWxm_NoS1K5Q" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.002264627" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="ANQAw7j1lk6hVSjUs_TXIA" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.010126747">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="GdnME41G-E6uod98honImQ" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0020705161" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="cAQCChYbFEqyV50w-bYv7Q" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.00925874">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="rNk24tIKTEWPZWYCjY4R2g" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0186500479" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <Parameter id="T6Ujdepf40mlHo1GGtjP3g" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0441002752" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <Parameter id="F-N7xVg440CbznrciVE6_g" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.30705627" displayUnit="1/cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <Parameter id="fX4hfCeKXk-81k9N4rTIfQ" name="pH" description="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="6">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
+                        <Info min="0" max="14" flag="122" seq="1" ref="0" bb="32" group="41" />
+                      </Parameter>
+                      <DistributedParameter id="adQKH3RPgkO_hqFzh9GCrw" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="M_LNjddH1Ue57tVh3nwBow" mode="Logical" isDefault="1">
+                        <Children>
+                          <Parameter id="4eKAp7KhoUGoSvUKR9GlGA" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="32" group="32" />
+                          </Parameter>
+                          <Parameter id="ijI4apTsOkOfzA7C_aIMNw" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="292.6883">
+                            <Info min="0" flag="50" seq="1" ref="0" bb="32" group="32" />
+                          </Parameter>
+                        </Children>
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="122" seq="1" ref="0" bb="32" group="32" />
+                      </DistributedParameter>
+                      <Container id="tS8dQ9eH4kueADHFcqF8Lw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
+                        <Children>
+                          <Parameter id="t2hiGNIlTUuJICGz0VITBg" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="sAgLzzcSbU-Lro2PDBo-zw" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                          </Parameter>
+                          <Parameter id="uFE64-3nl0S0D5fIwrLD1g" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" rHSFormula="KEsnKsQgpU2gj_6DSPbLHw" value="0" displayUnit="µmol">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Parameter id="atqeLoy7kU6e1vy6GH-uqA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                          </Parameter>
+                          <Parameter id="OV-LMlNO4U6NNJk6P3-5ww" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="pLyHG64fYUuuwJbDRsgYXQ" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="eirz7bJJpku0dw8icXXBJQ" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="jnFn0dVW_UuaZKn4VZQsbw" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="E-rxVhalgEGQiLkm3qDiTA" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IQoV9Bf6fEeClxkhrWQndA" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="WJVG09eS_kOY1YQm3eKMKA" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="4y77xOcuwUu3mD-0abcfTw" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="xSMjTpfNj0SlZ9l9LY-i1g" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="HGw1h1qmUUaU5u59svvqag" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="zzrm2VTqnk-VkQPTRjy1UQ" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="D-O5q7FU9kGs7Oj13xfQWQ" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="0BIoGBSfPk6GN8ASp4jWww" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="KL0CMa-gw0eRoTHybxaRuA" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="AOydXpels02NIJ03PvDFJA" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IKKvq7FNH0WVqLL1WlK98g" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="2RdmfQd-zU-H9X8tpH6Gwg" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="PTWduXcrQE6TuiaHRV7EEQ" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="JgB5ZslZ6U22nXyESbM-8w" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cs_aXu3q5EC0C6PdBucAFw" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="pRGL83mnKEW5iIkf59VzHw" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="mHb-SliHRUiy2nu8AVrlRg" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="9A-idcUFOUCOinYlWRGVsA" name="Solubility" description="Solubility" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="iRY4N1Pqn0W2jBOrCG0ptg" isDefault="1" displayUnit="mg/l">
+                            <Info min="0" flag="122" seq="1" ref="0" bb="2" group="42" />
+                          </Parameter>
+                          <Parameter id="YbwQG-WTQkqPqSOAJchwHg" name="Solubility table" description="Solubility table" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="sPp7vgPS5EaDrVIJGaPr-Q" isDefault="1" displayUnit="mg/l">
+                            <Info min="0" flag="50" seq="1" ref="0" bb="2" group="42" />
+                          </Parameter>
+                          <Parameter id="HNdsPQG6wkyk8pcAasVWZA" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="laSZo7Mr50SoKS70JH3d2Q" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="vZkNqAdqe0i8tI3KNiGWQQ" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="YQERj92sg0eOeddA3tJEnw" isDefault="1" displayUnit="min">
+                            <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="pqPkphaATEO91bNTJKm_Vw" name="Effective concentration in lumen" description="In case of supersaturation: molecule amount divided by liquid volume. Otherwise: Min(intestinal solubility; molecule amount divided by liquid volume)." icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="MjUWb6J9o0C-1UWLMLGCqw" isDefault="1" displayUnit="µmol/l">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="42" />
+                          </Parameter>
+                        </Children>
+                      </Container>
+                    </Children>
+                  </Container>
+                  <Container id="B36E9D-lFUOd3Jraml_2Kg" name="UpperJejunum" description="Upper Jejunum" icon="UpperJejunum" mode="Physical" containerType="Compartment">
+                    <Tags>
+                      <Tag value="Lumen" />
+                      <Tag value="LumenSegment" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="IG4VugeakUyYrCgBFZmrhQ" name="Absorption of liquid" description="rate of liquid outflow" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="hyDD00OcRU64hzfPoDx1Aw" isDefault="1" displayUnit="1/min">
+                        <Info flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="k1JxUCDlt0KZNtGVyzjycg" name="Distal radius" description="Distal radius of intestinal segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="p-ifWBsgtkCYNe8r-x0_mQ" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="__F8FHdgKUyPNFpRNl7s5Q" name="Effective surface area" description="Effective surface area of GI segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="ycPdUcIp5EKqELapSr2u-w" isDefault="1" displayUnit="cm²">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
+                        <Info min="0" flag="52" seq="1" ref="0" bb="32" group="33" />
+                      </Parameter>
+                      <Parameter id="H-0TVGOtQEey1PyIm4j3GQ" name="FillLevelFlag" description="Fill Level Flag" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="7HeksdzzjUeQj7kX8vDHbg" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="W1r4pkWtjkKlXDOvrd2qaw" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="1idWGEaDeE2qn5k830utxA" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="tQlha8_Ap0mndDoYA7mW7g" name="Geometric surface area" description="Geometric surface area of GI segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="c4Zv_ty3ZEOIEkFTsiKx8A" isDefault="1" displayUnit="cm²">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="62" seq="1" ref="0" bb="32" group="33" />
+                      </Parameter>
+                      <Parameter id="iPwuznaMXEGE0rTMQ9AApw" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="eMZ9igVDL0aaHT2o0W9pCg" isDefault="1" displayUnit="1/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="rdMMhm8oMUeSjP_0ETAWQw" name="Length" description="Length" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="-nYOr4fSp0GX3ocYyuhcOw" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="106" seq="1" ref="0" bb="32" group="34" />
+                      </Parameter>
+                      <Parameter id="_uv7NIdtGUSFL-bOdjGIYQ" name="Liquid" description="Liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="N0wzZBKIDkiUKbOSRMr88w" isDefault="1" rHSFormula="61WgkpcYv0KrKPB6a_ld2Q" displayUnit="l">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="0mxgkLwpdEiz_DGeqmE-nQ" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="8icURHoFvkuBE3I4_Pv1Ig" isDefault="1" displayUnit="l/min">
+                        <Info flag="52" seq="1" ref="0" bb="2" group="39" />
+                      </Parameter>
+                      <Parameter id="e1M9L0N5MEWKm8C0vrSArA" name="Proximal radius" description="Proximal radius of intestinal segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="68xm_j1F_kadz1plb4Humw" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="npXBZMjhikuv65dVj9JuhA" name="Secretion of liquid" description="Rate of liquid inflow" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="QKuhUvR0v0ms0Y1lEr5ogQ" isDefault="1" displayUnit="l/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="RuwQllenOUC6ASYraSjoMA" name="Thickness of gut wall" description="Thickness of Gut Wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Zhmtbn4PVkKNtMUGll4olg" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="38" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <Parameter id="rQCCF5Y8Z02PdUzNNrG6qg" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="WpAy5WPuG0WjdRWkmGKlHA" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="62" seq="1" ref="0" bb="2" group="56" />
+                      </Parameter>
+                      <Parameter id="46ZhOyDSLEOLB17hau6ozA" name="Volume (gut wall)" description="Volume of the gut wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="y_Gtl5GN-ECXlADZZXSg2w" isDefault="1" displayUnit="l">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="62" seq="1" ref="0" bb="32" group="44" />
+                      </Parameter>
+                      <Parameter id="j55nCPFhFkeU8qn0S3-U-w" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="jUuicTjwYECqpkpEHOcv6w" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="sdJKy2bAl0yjsIxF__8woQ" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.064841">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="58" seq="1" ref="0" bb="32" group="43" />
+                      </Parameter>
+                      <Parameter id="4H9n8dusAkKRKSuAupm2LQ" name="Intestinal transit rate" description="Transit rate along intestinal segments" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="5.0162" displayUnit="1/min">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="54" seq="1" ref="0" bb="32" group="46" />
+                      </Parameter>
+                      <Parameter id="1q9MX3p0O0WvKaR9MPitOQ" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0670329582" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="34" />
+                      </Parameter>
+                      <Parameter id="MA8W7Dt50UKN9-uaXZlkBg" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.299751712">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="34" />
+                      </Parameter>
+                      <Parameter id="B7W_J0Qq302hTy3sdKO_Ow" name="Microvilli factor" description="Microvilli factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="25">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="38" seq="1" ref="0" bb="32" group="33" />
+                      </Parameter>
+                      <Parameter id="gFMhn9di8kG64-tv4muRbQ" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0020705161" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="T-IkPGyDIU2cFAqgEATWRw" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.00925874">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="0AsZU1MylkaMuhO-ZmyAFg" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0019411088" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="ESGoZ7u1MkivBdti0bH0Dw" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.008680069">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="027KZPb2-kSwNj97_bZBZQ" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.024936327" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <Parameter id="WjRit3FDHUe9zzTf2zrzZQ" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0589752766" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <Parameter id="Aq_Q0qKdpkm9F26Lf60MAQ" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.30703115" displayUnit="1/cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <Parameter id="bh6sVg7UG0GWs1vYdLnsJg" name="pH" description="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="6.25">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
+                        <Info min="0" max="14" flag="122" seq="1" ref="0" bb="32" group="41" />
+                      </Parameter>
+                      <DistributedParameter id="HptuRsI63Ems7AwU9Oe8qg" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="OHTb1v_0TUe9r5rn3zEhlw" mode="Logical" isDefault="1">
+                        <Children>
+                          <Parameter id="bWniqqq8Vk-aI6uo7BSsxQ" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="32" group="32" />
+                          </Parameter>
+                          <Parameter id="mQk-j0IyKk2Q0vp8VzrxTA" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="447.9877">
+                            <Info min="0" flag="50" seq="1" ref="0" bb="32" group="32" />
+                          </Parameter>
+                        </Children>
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="122" seq="1" ref="0" bb="32" group="32" />
+                      </DistributedParameter>
+                      <Container id="81lHEQ4Ze0etsCKZIa0Kxg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
+                        <Children>
+                          <Parameter id="_dane1VvUEGsSb2AOzGnQg" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="sAgLzzcSbU-Lro2PDBo-zw" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                          </Parameter>
+                          <Parameter id="UeHa2hSHsEyAzEq8h0N_xg" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" rHSFormula="rN-jXn9r7kqheKuPHqLnQQ" value="0" displayUnit="µmol">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Parameter id="3yPEkK4TjUee6XS3z5V45g" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                          </Parameter>
+                          <Parameter id="Rv5x_20okEGPHGf6H2Hzlw" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="pLyHG64fYUuuwJbDRsgYXQ" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="KmcUSd-s2EyMsIyG0Zsdcg" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="jnFn0dVW_UuaZKn4VZQsbw" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="RhzyFvJ1H024sg0a_sD0yQ" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IQoV9Bf6fEeClxkhrWQndA" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="TmlrtvhRFUScBD_f5rW7Aw" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="4y77xOcuwUu3mD-0abcfTw" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="hxahDzBP5UKw4siuJNJzPg" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="HGw1h1qmUUaU5u59svvqag" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="st9iE-JD8UWlNqsrvvinKg" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="D-O5q7FU9kGs7Oj13xfQWQ" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="s0pNTla8EkCio5--Zv4uFA" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="KL0CMa-gw0eRoTHybxaRuA" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="46W9FiLo60-MvJaMPDJsFw" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IKKvq7FNH0WVqLL1WlK98g" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="vDFvLqg5bUO1uSCtPg9W-w" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="PTWduXcrQE6TuiaHRV7EEQ" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="tPQ3PCBnIEaBz50tMwWFCQ" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cs_aXu3q5EC0C6PdBucAFw" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="ZXiXVflhFESJvuhWiT_TFQ" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="mHb-SliHRUiy2nu8AVrlRg" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="KaqdH-DasU61ZjWqNhNrMA" name="Solubility" description="Solubility" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="iRY4N1Pqn0W2jBOrCG0ptg" isDefault="1" displayUnit="mg/l">
+                            <Info min="0" flag="122" seq="1" ref="0" bb="2" group="42" />
+                          </Parameter>
+                          <Parameter id="IZuJ0s3SPEujmo32Gy9kyQ" name="Solubility table" description="Solubility table" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="sPp7vgPS5EaDrVIJGaPr-Q" isDefault="1" displayUnit="mg/l">
+                            <Info min="0" flag="50" seq="1" ref="0" bb="2" group="42" />
+                          </Parameter>
+                          <Parameter id="6Yp4VoJbg0KLwStkAinoZQ" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="laSZo7Mr50SoKS70JH3d2Q" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="V0Vy_opxIEyKQu6LzAlH0A" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="YQERj92sg0eOeddA3tJEnw" isDefault="1" displayUnit="min">
+                            <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="u3abfqqh4EW_H5iVJwK5zg" name="Effective concentration in lumen" description="In case of supersaturation: molecule amount divided by liquid volume. Otherwise: Min(intestinal solubility; molecule amount divided by liquid volume)." icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="MjUWb6J9o0C-1UWLMLGCqw" isDefault="1" displayUnit="µmol/l">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="42" />
+                          </Parameter>
+                        </Children>
+                      </Container>
+                    </Children>
+                  </Container>
+                  <Container id="d6r-EDw0QkWFAW4A9RaMOg" name="LowerJejunum" description="Lower Jejunum" icon="LowerJejunum" mode="Physical" containerType="Compartment">
+                    <Tags>
+                      <Tag value="Lumen" />
+                      <Tag value="LumenSegment" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="GiBohuTpRkycBYHIYBKzsA" name="Absorption of liquid" description="rate of liquid outflow" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="OVZkt8S5V0KBO-xr_2SKRQ" isDefault="1" displayUnit="1/min">
+                        <Info flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="BbFImogw-kOJLbS1r4qdrw" name="Distal radius" description="Distal radius of intestinal segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="p-ifWBsgtkCYNe8r-x0_mQ" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="ie2WN-cdQUCUsHNYt0xC7Q" name="Effective surface area" description="Effective surface area of GI segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="ycPdUcIp5EKqELapSr2u-w" isDefault="1" displayUnit="cm²">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
+                        <Info min="0" flag="52" seq="1" ref="0" bb="32" group="33" />
+                      </Parameter>
+                      <Parameter id="KNMQR3-VS0aCFxK15qQW_g" name="FillLevelFlag" description="Fill Level Flag" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="7HeksdzzjUeQj7kX8vDHbg" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="hpV9Sdxrj0C0ymT9N9zIcQ" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="1idWGEaDeE2qn5k830utxA" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="RkgZRxeJT0KKX9kUBP2TGA" name="Geometric surface area" description="Geometric surface area of GI segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="c4Zv_ty3ZEOIEkFTsiKx8A" isDefault="1" displayUnit="cm²">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="62" seq="1" ref="0" bb="32" group="33" />
+                      </Parameter>
+                      <Parameter id="MMffj1BAbUKYn4Bkk7ocWg" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="QrWENhkyAkiVcc1IC_5Wcg" isDefault="1" displayUnit="1/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="gGSESAm0m0q1j3hBCfNzuA" name="Length" description="Length" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="-nYOr4fSp0GX3ocYyuhcOw" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="106" seq="1" ref="0" bb="32" group="34" />
+                      </Parameter>
+                      <Parameter id="vboJXQvYjUG8-V46Me_Dow" name="Liquid" description="Liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="N0wzZBKIDkiUKbOSRMr88w" isDefault="1" rHSFormula="kkjZjh-hNUmceBqO_q4Hzg" displayUnit="l">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="uKtu_PyoF0ic7Ul4ILESCA" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="bwsvbaLdVUei639qOun4Fg" isDefault="1" displayUnit="l/min">
+                        <Info flag="52" seq="1" ref="0" bb="2" group="39" />
+                      </Parameter>
+                      <Parameter id="7oeuDI0JxkO2UzAyWmUQWA" name="Proximal radius" description="Proximal radius of intestinal segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="68xm_j1F_kadz1plb4Humw" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="jlKkRu-nyUOBcnQ18mct8g" name="Secretion of liquid" description="Rate of liquid inflow" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="cGIMx9jqh0yIoDGu6zhoMg" isDefault="1" displayUnit="l/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="gVH-8jYAx02z3EmCyxokew" name="Thickness of gut wall" description="Thickness of Gut Wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Zhmtbn4PVkKNtMUGll4olg" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="38" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <Parameter id="l-B-D6j6yEGZbuKi4o3lNg" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="WpAy5WPuG0WjdRWkmGKlHA" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="62" seq="1" ref="0" bb="2" group="56" />
+                      </Parameter>
+                      <Parameter id="P8VBbyCJv0KcFzMfP0_0Yw" name="Volume (gut wall)" description="Volume of the gut wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="sXBylCkM7EWBp2pQKfYWzA" isDefault="1" displayUnit="l">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="62" seq="1" ref="0" bb="32" group="44" />
+                      </Parameter>
+                      <Parameter id="0tBPBVNxxEW09WoPQ-S2yg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="jUuicTjwYECqpkpEHOcv6w" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="KkRwUpD0N0yPxMBk9ZMzyQ" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.064841">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="58" seq="1" ref="0" bb="32" group="43" />
+                      </Parameter>
+                      <Parameter id="j1-mwAExqk6FWILMb31xSg" name="Intestinal transit rate" description="Transit rate along intestinal segments" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="5.0162" displayUnit="1/min">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="54" seq="1" ref="0" bb="32" group="46" />
+                      </Parameter>
+                      <Parameter id="1C9K3kT10UC0HtJW_8sS5w" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0670329582" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="34" />
+                      </Parameter>
+                      <Parameter id="UNAJoBXsA0mQYJ10K-oOxA" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.299751712">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="34" />
+                      </Parameter>
+                      <Parameter id="9Ne51zP0rU2y-4jY2U9EpA" name="Microvilli factor" description="Microvilli factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="25">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="38" seq="1" ref="0" bb="32" group="33" />
+                      </Parameter>
+                      <Parameter id="B2yPGBQ2tUCpa4kJHnhzfw" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0019411088" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="dr6llmzEvEil7AFSUCnRbw" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.008680069">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="KnIoBp96s0W6UJ1v4BLP8w" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0018117016" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="X6UWtCp_NE-TvpFy7X3afA" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.008101398">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="SEhdnDaaT02uLz1ektebLQ" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0196976609" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <Parameter id="NNQKGgcYFkSqC9VP4-dpnA" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0465856499" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <Parameter id="PoYedIFzL0-yauOvY2lxAQ" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.30703115" displayUnit="1/cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <Parameter id="rY5OrjStm0akW32GfxvE2Q" name="pH" description="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="6.9167">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
+                        <Info min="0" max="14" flag="122" seq="1" ref="0" bb="32" group="41" />
+                      </Parameter>
+                      <DistributedParameter id="_ZdwjIf1HESX0kj-68Xpmw" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="UuyDUbKZjEihUO5IzrmEHQ" mode="Logical" isDefault="1">
+                        <Children>
+                          <Parameter id="A5Bsz6Zq4k6qZG-VSjq-Vg" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="32" group="32" />
+                          </Parameter>
+                          <Parameter id="If_xSJA27Eqy3WMpgm6GnQ" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="372.9358">
+                            <Info min="0" flag="50" seq="1" ref="0" bb="32" group="32" />
+                          </Parameter>
+                        </Children>
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="122" seq="1" ref="0" bb="32" group="32" />
+                      </DistributedParameter>
+                      <Container id="bIMZHBqiD0-Pwma7Lmd7-w" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
+                        <Children>
+                          <Parameter id="2U0cHFcZVkm17B-zKw4JlA" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="sAgLzzcSbU-Lro2PDBo-zw" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                          </Parameter>
+                          <Parameter id="CwUMi9acF0SnltjjDO8L7Q" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" rHSFormula="pGe_l_acJUuqOiatMow8Xg" value="0" displayUnit="µmol">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Parameter id="HR0WTsZ6aUKU7s577V_uow" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                          </Parameter>
+                          <Parameter id="M8ZvkpamP0OD_zZnvdNcLA" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="pLyHG64fYUuuwJbDRsgYXQ" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="p2uYmsok80mae0PwV-gsWQ" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="jnFn0dVW_UuaZKn4VZQsbw" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="cbjVAfs7J0a3lmNqvfqCDA" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IQoV9Bf6fEeClxkhrWQndA" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="hY8qV1xuqk6uWyT8FPpskw" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="4y77xOcuwUu3mD-0abcfTw" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="F5S4-Odq3E-MTerxaL5nGg" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="HGw1h1qmUUaU5u59svvqag" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="XpPlhEcqPUefma0MsrR0WA" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="D-O5q7FU9kGs7Oj13xfQWQ" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="8MqtMHlHf0KaEeLCir8s3A" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="KL0CMa-gw0eRoTHybxaRuA" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="gmw3RZbpHUK7qAWRmxmLyA" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IKKvq7FNH0WVqLL1WlK98g" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="agNcvEZ3eEuWsK5LPxPfgg" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="PTWduXcrQE6TuiaHRV7EEQ" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="4Y3vbHGrWEOfJssUSGdL_w" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cs_aXu3q5EC0C6PdBucAFw" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="4raSjxSuXkSWowKHVgK_Cg" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="mHb-SliHRUiy2nu8AVrlRg" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="304jCwh4Q0CNUCdv_POruw" name="Solubility" description="Solubility" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="iRY4N1Pqn0W2jBOrCG0ptg" isDefault="1" displayUnit="mg/l">
+                            <Info min="0" flag="122" seq="1" ref="0" bb="2" group="42" />
+                          </Parameter>
+                          <Parameter id="FsSXORH5gUOTJY-BxT-oLQ" name="Solubility table" description="Solubility table" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="sPp7vgPS5EaDrVIJGaPr-Q" isDefault="1" displayUnit="mg/l">
+                            <Info min="0" flag="50" seq="1" ref="0" bb="2" group="42" />
+                          </Parameter>
+                          <Parameter id="7VU1JF8jYkCE7jHADGYt2w" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="laSZo7Mr50SoKS70JH3d2Q" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="7-zm3a6yF0yX7vTYrxjr4A" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="YQERj92sg0eOeddA3tJEnw" isDefault="1" displayUnit="min">
+                            <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="AuPQW6ksZEeWP-Ssep0vqg" name="Effective concentration in lumen" description="In case of supersaturation: molecule amount divided by liquid volume. Otherwise: Min(intestinal solubility; molecule amount divided by liquid volume)." icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="MjUWb6J9o0C-1UWLMLGCqw" isDefault="1" displayUnit="µmol/l">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="42" />
+                          </Parameter>
+                        </Children>
+                      </Container>
+                    </Children>
+                  </Container>
+                  <Container id="cmRRlhfsYkmrjs8gJ_QPNg" name="UpperIleum" description="Upper Ileum" icon="UpperIleum" mode="Physical" containerType="Compartment">
+                    <Tags>
+                      <Tag value="Lumen" />
+                      <Tag value="LumenSegment" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="cMn1MKzioEa-acF3zpuVpw" name="Absorption of liquid" description="rate of liquid outflow" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="y3tHSBPXyEWUX--RGEvFTQ" isDefault="1" displayUnit="1/min">
+                        <Info flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="mlWKxijiBEiqtAlHOClMzg" name="Distal radius" description="Distal radius of intestinal segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="p-ifWBsgtkCYNe8r-x0_mQ" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="ZYHHSe8n3ke98NedrH2Xeg" name="Effective surface area" description="Effective surface area of GI segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="ycPdUcIp5EKqELapSr2u-w" isDefault="1" displayUnit="cm²">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
+                        <Info min="0" flag="52" seq="1" ref="0" bb="32" group="33" />
+                      </Parameter>
+                      <Parameter id="p18jdZ9HK0e0NUCVqPTmsg" name="FillLevelFlag" description="Fill Level Flag" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="7HeksdzzjUeQj7kX8vDHbg" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="2rs163shQU2fuqdJnYE45A" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="1idWGEaDeE2qn5k830utxA" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="U04425-o_USnGFc3hyifJQ" name="Geometric surface area" description="Geometric surface area of GI segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="c4Zv_ty3ZEOIEkFTsiKx8A" isDefault="1" displayUnit="cm²">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="62" seq="1" ref="0" bb="32" group="33" />
+                      </Parameter>
+                      <Parameter id="3zzg3wFKCkiYb6Q9mDjABQ" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="8YcGKxMdL0mK__Ns21kjXw" isDefault="1" displayUnit="1/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="e-NIlrG41EmQGPnVCqYK2w" name="Length" description="Length" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="-nYOr4fSp0GX3ocYyuhcOw" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="106" seq="1" ref="0" bb="32" group="34" />
+                      </Parameter>
+                      <Parameter id="NRewxuNrNESl8KGW4mUOBw" name="Liquid" description="Liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="N0wzZBKIDkiUKbOSRMr88w" isDefault="1" rHSFormula="wiC-r8ZiqkyRnLrAty901A" displayUnit="l">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="kTKeE2WXYkCHQTXyA_-FFQ" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="55KdrJoNSkSxTgicTEUMhQ" isDefault="1" displayUnit="l/min">
+                        <Info flag="52" seq="1" ref="0" bb="2" group="39" />
+                      </Parameter>
+                      <Parameter id="SOjWuYtVL0-f90hnU_CJJA" name="Proximal radius" description="Proximal radius of intestinal segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="68xm_j1F_kadz1plb4Humw" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="w04iW2TfbU6rK2D6i3tZ4w" name="Secretion of liquid" description="Rate of liquid inflow" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="8rtMrqZQ4kCM1xb162mpPg" isDefault="1" displayUnit="l/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="DHjPhkCeHkiRO77UNp9h8g" name="Thickness of gut wall" description="Thickness of Gut Wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Zhmtbn4PVkKNtMUGll4olg" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="38" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <Parameter id="l44TL60g2Uq4D3SDglULng" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="WpAy5WPuG0WjdRWkmGKlHA" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="62" seq="1" ref="0" bb="2" group="56" />
+                      </Parameter>
+                      <Parameter id="eeorKtZvN0KQuqS2OJR3dw" name="Volume (gut wall)" description="Volume of the gut wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="Y7-g6OZD1EuWOoCTEko_zg" isDefault="1" displayUnit="l">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="62" seq="1" ref="0" bb="32" group="44" />
+                      </Parameter>
+                      <Parameter id="FjnBB9NZpEW6_xv8zFOgNA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="jUuicTjwYECqpkpEHOcv6w" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="51_WXlceC0aZIaiQ03O52w" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.064841">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="58" seq="1" ref="0" bb="32" group="43" />
+                      </Parameter>
+                      <Parameter id="wPF5McXWgUGDMHTpPTnM8A" name="Intestinal transit rate" description="Transit rate along intestinal segments" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="3.3745" displayUnit="1/min">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="54" seq="1" ref="0" bb="32" group="46" />
+                      </Parameter>
+                      <Parameter id="2nwrjAfzd0WnuTlsSDVT6A" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0996435866" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="34" />
+                      </Parameter>
+                      <Parameter id="OSLju73ldEWhtZ2WjVI1nQ" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.445576869">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="34" />
+                      </Parameter>
+                      <Parameter id="fOPULcSGbkaFsOUm-pmiUw" name="Microvilli factor" description="Microvilli factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="25">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="38" seq="1" ref="0" bb="32" group="33" />
+                      </Parameter>
+                      <Parameter id="JPvPCUPwHEGQ_owJt0O_OA" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0018117016" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="nq5NRjjq702BJoU7yAL2Jw" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.008101398">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="sRlYgIKsJk-4ZkEF6lqKSg" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0015528871" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="cuyN1ik25E6Qk0tnDOSTXg" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.006944055">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="l7jQESC_f02HZF1d2nnzEQ" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0260258863" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <Parameter id="4i093G07UEW3R8xiRmoiJw" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.061552122" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <Parameter id="-fcuGC2Xuky-v9kWDHwK5Q" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.30703115" displayUnit="1/cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <Parameter id="gMVtpLEeCke5T5chV_fKPQ" name="pH" description="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.2083">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
+                        <Info min="0" max="14" flag="122" seq="1" ref="0" bb="32" group="41" />
+                      </Parameter>
+                      <DistributedParameter id="rb2KrDTa1UG5RHn2k5FCyQ" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="2LOgvb5C3k66abbNzobt3Q" mode="Logical" isDefault="1">
+                        <Children>
+                          <Parameter id="KJXnOIrZH0GmBokDWu8XGA" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="32" group="32" />
+                          </Parameter>
+                          <Parameter id="fPwphSV_JUmdSLN_Uynasg" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="260.7527">
+                            <Info min="0" flag="50" seq="1" ref="0" bb="32" group="32" />
+                          </Parameter>
+                        </Children>
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="122" seq="1" ref="0" bb="32" group="32" />
+                      </DistributedParameter>
+                      <Container id="85YRVOIufUO-SYkr3LyR3w" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
+                        <Children>
+                          <Parameter id="hPD6ClKBSUORKZJUfV6Nrg" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="sAgLzzcSbU-Lro2PDBo-zw" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                          </Parameter>
+                          <Parameter id="FdM4XbiMUkudIuUIFO8PEQ" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" rHSFormula="0nH5V-caOUa67p6vvduHVw" value="0" displayUnit="µmol">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Parameter id="tisaYi3prUOSeTLAbvdk0w" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                          </Parameter>
+                          <Parameter id="qZKPgiCjjkmjuB2hS1QNUg" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="pLyHG64fYUuuwJbDRsgYXQ" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="NdQkw6TaVEyMBijtwZtClQ" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="jnFn0dVW_UuaZKn4VZQsbw" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="MI20CVMsq0yjImpakiGC1A" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IQoV9Bf6fEeClxkhrWQndA" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="SRcs9V1HBkKo1t0Le54PMA" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="4y77xOcuwUu3mD-0abcfTw" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="vQR_nn49okau41JjaBfCpQ" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="HGw1h1qmUUaU5u59svvqag" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="LWtGl0whikqtWIBPjgyQYA" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="D-O5q7FU9kGs7Oj13xfQWQ" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="FWnWE_RfrEaXPXNAmCc9rg" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="KL0CMa-gw0eRoTHybxaRuA" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="Dg5vpIrvlEarrMS-yLtnzA" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IKKvq7FNH0WVqLL1WlK98g" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="3ibFLuzJO0uap-T9rqvf4g" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="PTWduXcrQE6TuiaHRV7EEQ" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="YVrxSPLjl0-3G7Iz9hCMAQ" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cs_aXu3q5EC0C6PdBucAFw" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="EEaXTQOVTEauKcslifMr2Q" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="mHb-SliHRUiy2nu8AVrlRg" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="ttqblh_eWUC7puJ_oJ8AuA" name="Solubility" description="Solubility" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="iRY4N1Pqn0W2jBOrCG0ptg" isDefault="1" displayUnit="mg/l">
+                            <Info min="0" flag="122" seq="1" ref="0" bb="2" group="42" />
+                          </Parameter>
+                          <Parameter id="DXtSv_25Q0OZaP2aT9p1zw" name="Solubility table" description="Solubility table" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="sPp7vgPS5EaDrVIJGaPr-Q" isDefault="1" displayUnit="mg/l">
+                            <Info min="0" flag="50" seq="1" ref="0" bb="2" group="42" />
+                          </Parameter>
+                          <Parameter id="2dotr9RzHUmhyZrQexfdYQ" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="laSZo7Mr50SoKS70JH3d2Q" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="ygJ_k304ikyjUQcJYPVU-g" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="YQERj92sg0eOeddA3tJEnw" isDefault="1" displayUnit="min">
+                            <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="u2yPoViJ90SQ3slTwxqnFA" name="Effective concentration in lumen" description="In case of supersaturation: molecule amount divided by liquid volume. Otherwise: Min(intestinal solubility; molecule amount divided by liquid volume)." icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="MjUWb6J9o0C-1UWLMLGCqw" isDefault="1" displayUnit="µmol/l">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="42" />
+                          </Parameter>
+                        </Children>
+                      </Container>
+                    </Children>
+                  </Container>
+                  <Container id="wen_VH77NE2ORWa-gn7jMw" name="LowerIleum" description="Lower Ileum" icon="LowerIleum" mode="Physical" containerType="Compartment">
+                    <Tags>
+                      <Tag value="Lumen" />
+                      <Tag value="LumenSegment" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="FthIstgDJE25-jjmKCUZvg" name="Absorption of liquid" description="rate of liquid outflow" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="v7gy48OkGEW9fIXU5jI_AQ" isDefault="1" displayUnit="1/min">
+                        <Info flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="D2yCMUpSM0GTUZZM_v_D1w" name="Distal radius" description="Distal radius of intestinal segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="p-ifWBsgtkCYNe8r-x0_mQ" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="G7q-vrYHpk6eafR_j6bIZA" name="Effective surface area" description="Effective surface area of GI segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="ycPdUcIp5EKqELapSr2u-w" isDefault="1" displayUnit="cm²">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
+                        <Info min="0" flag="52" seq="1" ref="0" bb="32" group="33" />
+                      </Parameter>
+                      <Parameter id="rYHkrqRJukiO_-42cHzXKg" name="FillLevelFlag" description="Fill Level Flag" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="7HeksdzzjUeQj7kX8vDHbg" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="rVCwM5ujU0WlmmNOKLvsfA" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="1idWGEaDeE2qn5k830utxA" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="GDpsbljdaUqAVGw0aTx4Zw" name="Geometric surface area" description="Geometric surface area of GI segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="c4Zv_ty3ZEOIEkFTsiKx8A" isDefault="1" displayUnit="cm²">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="62" seq="1" ref="0" bb="32" group="33" />
+                      </Parameter>
+                      <Parameter id="v9_QAsNiyE67ZwgBruPJfg" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="9NzJWLMhDUWzcKdySy-Nkw" isDefault="1" displayUnit="1/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="tn2-NDuqlECcMcQjA7VqyQ" name="Length" description="Length" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="-nYOr4fSp0GX3ocYyuhcOw" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="106" seq="1" ref="0" bb="32" group="34" />
+                      </Parameter>
+                      <Parameter id="FxtY4FQH4kqe7N7c73ZReA" name="Liquid" description="Liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="N0wzZBKIDkiUKbOSRMr88w" isDefault="1" rHSFormula="GSzpIFNb4EaVSGFfwXre5A" displayUnit="l">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="0Uevy9FozkucOROFQlC6ig" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="omDmX_l6dUSwjxnaPrTh1g" isDefault="1" displayUnit="l/min">
+                        <Info flag="52" seq="1" ref="0" bb="2" group="39" />
+                      </Parameter>
+                      <Parameter id="asZ1hecvwkaQIIOtQSLe9g" name="Proximal radius" description="Proximal radius of intestinal segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="68xm_j1F_kadz1plb4Humw" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="_14j6HpwG0uaLucixtVBzA" name="Secretion of liquid" description="Rate of liquid inflow" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="78ug1hbmxUi6nkJVuK3U2Q" isDefault="1" displayUnit="l/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="V7Y9sLtDDkixtXSIhoVAZQ" name="Thickness of gut wall" description="Thickness of Gut Wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Zhmtbn4PVkKNtMUGll4olg" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="38" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <Parameter id="_IjqPgKSFkaSwdjS4r1frQ" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="WpAy5WPuG0WjdRWkmGKlHA" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="62" seq="1" ref="0" bb="2" group="56" />
+                      </Parameter>
+                      <Parameter id="7lghO9R7BUKjp9FINyKWZQ" name="Volume (gut wall)" description="Volume of the gut wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="NJ-4DGu0_kedDIyatR7KJQ" isDefault="1" displayUnit="l">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="62" seq="1" ref="0" bb="32" group="44" />
+                      </Parameter>
+                      <Parameter id="Sz0sl11DkEmVDeVd7M83HA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="jUuicTjwYECqpkpEHOcv6w" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="ZxVqOp46Ak-XeJBNR6DHLw" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.064841">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="58" seq="1" ref="0" bb="32" group="43" />
+                      </Parameter>
+                      <Parameter id="dg_o0sNrSk63jzSiRHGQ-g" name="Intestinal transit rate" description="Transit rate along intestinal segments" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="3.3745" displayUnit="1/min">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="54" seq="1" ref="0" bb="32" group="46" />
+                      </Parameter>
+                      <Parameter id="6ByDOroswU-Njwa9v4-YaA" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0996435866" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="34" />
+                      </Parameter>
+                      <Parameter id="bM8n2dzKVECIAj9JY0v_SQ" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.445576869">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="34" />
+                      </Parameter>
+                      <Parameter id="ZDdswONClUivv1AdF8p7Vw" name="Microvilli factor" description="Microvilli factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="25">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="38" seq="1" ref="0" bb="32" group="33" />
+                      </Parameter>
+                      <Parameter id="bIqPr4JqrUWjslWZVMUcpw" name="pH" description="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.4583">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
+                        <Info min="0" max="14" flag="122" seq="1" ref="0" bb="32" group="41" />
+                      </Parameter>
+                      <Parameter id="o_fj_iu_ZkCNr4AwnDtdrA" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0015528871" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="DIbDtFeq40iwzixjBgqiRw" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.006944055">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="1pUwWbCVlkyCtWQD1r-a8w" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0012940725" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="vXQFv1uB3EKK0TPzyBBxrg" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.005786713">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="Q4HSTNn5IUKktnxjHR-Ieg" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0148137399" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <Parameter id="gGymIbK1HEGucfjnZlPrhA" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0350288649" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <Parameter id="euMGJ5Ttt0-tEBufbMYQoA" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.30705627" displayUnit="1/cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <DistributedParameter id="Xron-FZRHE-OUH_dicZQuw" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="jrFU046W4ESkMH2J6VuUww" mode="Logical" isDefault="1">
+                        <Children>
+                          <Parameter id="utXXuHCNT0WdANpsP6YLzw" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="32" group="32" />
+                          </Parameter>
+                          <Parameter id="m4gbFYLrMUmO-f5C7Iq3yg" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="146.565">
+                            <Info min="0" flag="50" seq="1" ref="0" bb="32" group="32" />
+                          </Parameter>
+                        </Children>
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="122" seq="1" ref="0" bb="32" group="32" />
+                      </DistributedParameter>
+                      <Container id="SpONVxxP8kqSjaJldpcnMA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
+                        <Children>
+                          <Parameter id="AqC85RqeRUKKNf5cVL0GQg" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="sAgLzzcSbU-Lro2PDBo-zw" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                          </Parameter>
+                          <Parameter id="HbMYw5XaLUq6KU5mmkcWqg" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" rHSFormula="zVtVOTSZhU6OVWqVTiklZg" value="0" displayUnit="µmol">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Parameter id="lXz4EQRWVku9TaF8-OipEQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                          </Parameter>
+                          <Parameter id="rK1xFqKD_EqZt3tvSHha-g" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="pLyHG64fYUuuwJbDRsgYXQ" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="ChFgJPvNXk-O4nKvhrA3Qg" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="jnFn0dVW_UuaZKn4VZQsbw" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="U2_cacd7F0uHgDx1g4yUjg" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IQoV9Bf6fEeClxkhrWQndA" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="2NOfanss4U-JcaUCD5k_Aw" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="4y77xOcuwUu3mD-0abcfTw" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="qs8ZKrzP3UCpVxj56ydqNw" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="HGw1h1qmUUaU5u59svvqag" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="hMPefBGBvkKEfkuZ-qTQiw" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="D-O5q7FU9kGs7Oj13xfQWQ" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="vSjXGtgnXEi0MNu6sPJbtg" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="KL0CMa-gw0eRoTHybxaRuA" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="CHb_N7BGPEufImk-8J1KiA" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IKKvq7FNH0WVqLL1WlK98g" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="merMSfGN6ke4TCCn15WZPw" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="PTWduXcrQE6TuiaHRV7EEQ" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="g8sea8MjNk2_I4W20zAOEg" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cs_aXu3q5EC0C6PdBucAFw" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="OJvj95rMH022L_aXF245QQ" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="mHb-SliHRUiy2nu8AVrlRg" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="7vXA-sfrfECGa2TETC-jzA" name="Solubility" description="Solubility" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="iRY4N1Pqn0W2jBOrCG0ptg" isDefault="1" displayUnit="mg/l">
+                            <Info min="0" flag="122" seq="1" ref="0" bb="2" group="42" />
+                          </Parameter>
+                          <Parameter id="Rzbh47g7b0y-78NitC3aqw" name="Solubility table" description="Solubility table" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="sPp7vgPS5EaDrVIJGaPr-Q" isDefault="1" displayUnit="mg/l">
+                            <Info min="0" flag="50" seq="1" ref="0" bb="2" group="42" />
+                          </Parameter>
+                          <Parameter id="18_C_d6CE02Nv4ODPRUmQg" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="laSZo7Mr50SoKS70JH3d2Q" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="IRNGy9ajR0y0_2uEIUiz8A" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="YQERj92sg0eOeddA3tJEnw" isDefault="1" displayUnit="min">
+                            <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="hmYGFsqRi0qXEGnVVsEsAQ" name="Effective concentration in lumen" description="In case of supersaturation: molecule amount divided by liquid volume. Otherwise: Min(intestinal solubility; molecule amount divided by liquid volume)." icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="MjUWb6J9o0C-1UWLMLGCqw" isDefault="1" displayUnit="µmol/l">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="42" />
+                          </Parameter>
+                        </Children>
+                      </Container>
+                    </Children>
+                  </Container>
+                  <Container id="3tZuU9v7b0uAi8jCQ6JTTQ" name="Caecum" description="Cecum" icon="Caecum" mode="Physical" containerType="Compartment">
+                    <Tags>
+                      <Tag value="Lumen" />
+                      <Tag value="LumenSegment" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="kFjyWcI4Y0ev_aZ_vaKbVA" name="Absorption of liquid" description="rate of liquid outflow" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Q1fBumzOek-DbtTCCNWwtw" isDefault="1" displayUnit="1/min">
+                        <Info flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="qO_p29Xr70uAwHOHojMbSQ" name="Distal radius" description="Distal radius of intestinal segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="p-ifWBsgtkCYNe8r-x0_mQ" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="IyEOOW-X0kWatlCnf80ZPA" name="Effective surface area" description="Effective surface area of GI segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="ycPdUcIp5EKqELapSr2u-w" isDefault="1" displayUnit="cm²">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
+                        <Info min="0" flag="52" seq="1" ref="0" bb="32" group="33" />
+                      </Parameter>
+                      <Parameter id="uuogvCdWBkOoOjnhtBbSnQ" name="FillLevelFlag" description="Fill Level Flag" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="7HeksdzzjUeQj7kX8vDHbg" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="CswDHyno70OzxD-Nuv0fLQ" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="1idWGEaDeE2qn5k830utxA" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="NUNhELRsUE60Y0C7GiE7IA" name="Geometric surface area" description="Geometric surface area of GI segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="c4Zv_ty3ZEOIEkFTsiKx8A" isDefault="1" displayUnit="cm²">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="62" seq="1" ref="0" bb="32" group="33" />
+                      </Parameter>
+                      <Parameter id="OQMOKl0umkCaHL5UVkCftQ" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="WYe41mNVfke4hs7izFNiWg" isDefault="1" displayUnit="1/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="4_0vhXvgi0us0Huiqm7v4g" name="Length" description="Length" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="-nYOr4fSp0GX3ocYyuhcOw" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="106" seq="1" ref="0" bb="32" group="34" />
+                      </Parameter>
+                      <Parameter id="6eVpwxYnP0S_NcaMDS13fg" name="Liquid" description="Liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="N0wzZBKIDkiUKbOSRMr88w" isDefault="1" rHSFormula="ra0mHrCHnUqsT6zjuofVTA" displayUnit="l">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="zY2EYkDNTEirz27k-Nd7dw" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="pZg-6eh8S0W338QDWxbIqQ" isDefault="1" displayUnit="l/min">
+                        <Info flag="52" seq="1" ref="0" bb="2" group="39" />
+                      </Parameter>
+                      <Parameter id="ADuZWjoLEEWMRuxZRJjmgQ" name="Proximal radius" description="Proximal radius of intestinal segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="68xm_j1F_kadz1plb4Humw" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="oubvgI86EUSvvtGMtMvE0w" name="Secretion of liquid" description="Rate of liquid inflow" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="tbz1zB4UAk-hthOHbNfM3g" isDefault="1" displayUnit="l/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="o6vJvF6QkkSWtH5Bjdb6gw" name="Thickness of gut wall" description="Thickness of Gut Wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Zhmtbn4PVkKNtMUGll4olg" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="38" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <Parameter id="dbYtEx0jwEmOwnxbdh-Meg" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="WpAy5WPuG0WjdRWkmGKlHA" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="62" seq="1" ref="0" bb="2" group="56" />
+                      </Parameter>
+                      <Parameter id="i2tZB8TNDEiR9MAo7y8tnw" name="Volume (gut wall)" description="Volume of the gut wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="RBOIWsF_e0GzRrTlBlDCLA" isDefault="1" displayUnit="l">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="62" seq="1" ref="0" bb="32" group="44" />
+                      </Parameter>
+                      <Parameter id="y2Rtnegl80uaGbAHQ_EPWQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="jUuicTjwYECqpkpEHOcv6w" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="a-yhIK4-CEOapqYF8LRU3Q" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0060009">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="58" seq="1" ref="0" bb="32" group="43" />
+                      </Parameter>
+                      <Parameter id="IMTuhFJLFEC7y4jxNzlhEg" name="Intestinal transit rate" description="Transit rate along intestinal segments" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="18.3333" displayUnit="1/min">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="54" seq="1" ref="0" bb="32" group="46" />
+                      </Parameter>
+                      <Parameter id="1wRykYVDvUStlg4dhwfRbg" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.1152851235" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="34" />
+                      </Parameter>
+                      <Parameter id="R3fllu1Ms0yW1XDWZlhVmA" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.026864843">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="34" />
+                      </Parameter>
+                      <Parameter id="vpviCSrGkkmSPseRG4Cb3w" name="Microvilli factor" description="Microvilli factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="38" seq="1" ref="0" bb="32" group="33" />
+                      </Parameter>
+                      <Parameter id="P7M7z0NLt0WKdQRdYHgHFQ" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.067256381" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="nemz2XNg8kCRAJLlwQ6NcA" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.015672726">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="NH5soGHyd0q8qNM4_qq7OA" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.067256381" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="eBVMdwjz0kareB7tU7bJGA" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.015672726">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="1Kr05vufu0Cn6ciu7u1RRA" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.00877" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <Parameter id="QJBC08bPf02TkyZCdMOzjw" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0446435379" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <Parameter id="LRaIQbEwwEq0X1h4DWAV3A" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0897885" displayUnit="1/cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <Parameter id="r3vdlQNYekapstfAQPE0Yw" name="pH" description="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="5.7">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
+                        <Info min="0" max="14" flag="122" seq="1" ref="0" bb="32" group="41" />
+                      </Parameter>
+                      <DistributedParameter id="OtW-lF7FCUGI6bacjSsefA" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="na5Xpp5pWEaomDKcdIA7kQ" mode="Logical" isDefault="1">
+                        <Children>
+                          <Parameter id="-PdPvz-nG0GgUoK-OWCgfQ" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="32" group="32" />
+                          </Parameter>
+                          <Parameter id="TqTdO1smwkyMyc1DgJfZyQ" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.8">
+                            <Info min="0" flag="50" seq="1" ref="0" bb="32" group="32" />
+                          </Parameter>
+                        </Children>
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="122" seq="1" ref="0" bb="32" group="32" />
+                      </DistributedParameter>
+                      <Container id="M7d1NZafUE-MX013L4GNJg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
+                        <Children>
+                          <Parameter id="nkFh35XOiUmbowfIK2gmdA" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="sAgLzzcSbU-Lro2PDBo-zw" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                          </Parameter>
+                          <Parameter id="W_g2eHgYcUirkwEebYKAiw" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" rHSFormula="KQLTSxsSVUCAQ8Qa9dCONA" value="0" displayUnit="µmol">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Parameter id="4R4AN4tWw0Cs96yP4rNgNQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                          </Parameter>
+                          <Parameter id="Yo0fz8VEcEG_excacwndQw" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="pLyHG64fYUuuwJbDRsgYXQ" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="8eVl8JPg40y_3ESjsDr00A" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="jnFn0dVW_UuaZKn4VZQsbw" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="e2j-uHFIcEuGgRqDu7raQQ" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IQoV9Bf6fEeClxkhrWQndA" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="I66npxTtskSgYbPSkeVPdA" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="4y77xOcuwUu3mD-0abcfTw" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="7lqCLyqaKk-SVSe54OMpTQ" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="HGw1h1qmUUaU5u59svvqag" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="rq1auVEmxUq5AVvjY_q94w" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="D-O5q7FU9kGs7Oj13xfQWQ" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="owm_iu9Rz0qUDX7s92zidA" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="KL0CMa-gw0eRoTHybxaRuA" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="vcgACESG-0e0yQOVo0xv5w" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IKKvq7FNH0WVqLL1WlK98g" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="JVA3jCg_DESVHOAmsmSf7g" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="PTWduXcrQE6TuiaHRV7EEQ" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="BrET9Ci0tEWtEFct_EO5yA" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cs_aXu3q5EC0C6PdBucAFw" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="ZxaF92NrAkKM0mmv7dzQrw" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="mHb-SliHRUiy2nu8AVrlRg" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="slmdrQBw9kyC6fTYskROyQ" name="Solubility" description="Solubility" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="iRY4N1Pqn0W2jBOrCG0ptg" isDefault="1" displayUnit="mg/l">
+                            <Info min="0" flag="122" seq="1" ref="0" bb="2" group="42" />
+                          </Parameter>
+                          <Parameter id="SxXTSS1LqEi9euMuF0xmSw" name="Solubility table" description="Solubility table" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="sPp7vgPS5EaDrVIJGaPr-Q" isDefault="1" displayUnit="mg/l">
+                            <Info min="0" flag="50" seq="1" ref="0" bb="2" group="42" />
+                          </Parameter>
+                          <Parameter id="wW4bfV8hpEiZPN7e649Ivw" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="laSZo7Mr50SoKS70JH3d2Q" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="o0KDmgpTcke1sQs_wdluvQ" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="YQERj92sg0eOeddA3tJEnw" isDefault="1" displayUnit="min">
+                            <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="1WjmvP4dnkCmEIDCPK5GOw" name="Effective concentration in lumen" description="In case of supersaturation: molecule amount divided by liquid volume. Otherwise: Min(intestinal solubility; molecule amount divided by liquid volume)." icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="MjUWb6J9o0C-1UWLMLGCqw" isDefault="1" displayUnit="µmol/l">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="42" />
+                          </Parameter>
+                        </Children>
+                      </Container>
+                    </Children>
+                  </Container>
+                  <Container id="YMbLwVT-lkaxj25aTkoiQg" name="ColonAscendens" description="Colon Ascendens" icon="ColonAscendens" mode="Physical" containerType="Compartment">
+                    <Tags>
+                      <Tag value="Lumen" />
+                      <Tag value="LumenSegment" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="6Hz7MTJJLEGA4vsOsTcEww" name="Absorption of liquid" description="rate of liquid outflow" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="tkkmnR4PcEKvkN0VdR6LWQ" isDefault="1" displayUnit="1/min">
+                        <Info flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="aVid3Gmya0iZkrtiIpDJUA" name="Distal radius" description="Distal radius of intestinal segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="p-ifWBsgtkCYNe8r-x0_mQ" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="KURWVdVZs0afgytMN6OzZw" name="Effective surface area" description="Effective surface area of GI segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="ycPdUcIp5EKqELapSr2u-w" isDefault="1" displayUnit="cm²">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
+                        <Info min="0" flag="52" seq="1" ref="0" bb="32" group="33" />
+                      </Parameter>
+                      <Parameter id="ykfeBpAabEmhV_RKbhM38Q" name="FillLevelFlag" description="Fill Level Flag" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="7HeksdzzjUeQj7kX8vDHbg" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="emEzQoWmhkmSDzTxiUm3BQ" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="1idWGEaDeE2qn5k830utxA" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="hjKVOBK89E2wk9lZmFHTyA" name="Geometric surface area" description="Geometric surface area of GI segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="c4Zv_ty3ZEOIEkFTsiKx8A" isDefault="1" displayUnit="cm²">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="62" seq="1" ref="0" bb="32" group="33" />
+                      </Parameter>
+                      <Parameter id="dmK2G-Xq_0urCvadqAC6Ig" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="s5HpSDrASUmW41jK-GT_BA" isDefault="1" displayUnit="1/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="vy5mu3CQR0GHWIABegI_Zw" name="Length" description="Length" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="-nYOr4fSp0GX3ocYyuhcOw" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="106" seq="1" ref="0" bb="32" group="34" />
+                      </Parameter>
+                      <Parameter id="ZKvj_fSvHE63D9VFB-yQBA" name="Liquid" description="Liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="N0wzZBKIDkiUKbOSRMr88w" isDefault="1" rHSFormula="giM7cNbj70yC48KMNzNfeg" displayUnit="l">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="JlNxrV0VFEGHwaNCwfB6SA" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="vOTTAch-OEGoFu6F7CTb8g" isDefault="1" displayUnit="l/min">
+                        <Info flag="52" seq="1" ref="0" bb="2" group="39" />
+                      </Parameter>
+                      <Parameter id="QStNvbCZG0CQ59BYRGNGig" name="Proximal radius" description="Proximal radius of intestinal segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="68xm_j1F_kadz1plb4Humw" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="ydf-0KmI10yozQPCrHkj6Q" name="Secretion of liquid" description="Rate of liquid inflow" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="2319-RO840i-HNWOBPguPg" isDefault="1" displayUnit="l/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="IvA3rDHs30-43xJ6F3J1XA" name="Thickness of gut wall" description="Thickness of Gut Wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Zhmtbn4PVkKNtMUGll4olg" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="38" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <Parameter id="XVuqz9Opw0asKaRifnUd4Q" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="WpAy5WPuG0WjdRWkmGKlHA" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="62" seq="1" ref="0" bb="2" group="56" />
+                      </Parameter>
+                      <Parameter id="9SMPDoRGDEKbBRWc-RsZPg" name="Volume (gut wall)" description="Volume of the gut wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="C4gfI3l89kqHL4-iH81OrA" isDefault="1" displayUnit="l">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="62" seq="1" ref="0" bb="32" group="44" />
+                      </Parameter>
+                      <Parameter id="rUcvOGEwm0OzahSh90L2Xg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="jUuicTjwYECqpkpEHOcv6w" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="c1Ttb_UP4UW3rpjWZspqZA" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0060009">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="58" seq="1" ref="0" bb="32" group="43" />
+                      </Parameter>
+                      <Parameter id="gGqR_TVcZUeX00nAWwPv6w" name="Intestinal transit rate" description="Transit rate along intestinal segments" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="1/min">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="54" seq="1" ref="0" bb="32" group="46" />
+                      </Parameter>
+                      <Parameter id="wDsuY5-oL0q7QlShU_6GHA" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.3117189273" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="34" />
+                      </Parameter>
+                      <Parameter id="hxRjQBntAkevNN6sVnumgg" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.075727844">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="34" />
+                      </Parameter>
+                      <Parameter id="DqMoRlF-BUWLgJiIfdHJdQ" name="Microvilli factor" description="Microvilli factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="38" seq="1" ref="0" bb="32" group="33" />
+                      </Parameter>
+                      <Parameter id="cD-RJCJaUUWBHX4f1P0Hzg" name="pH" description="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="5.6">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
+                        <Info min="0" max="14" flag="122" seq="1" ref="0" bb="32" group="41" />
+                      </Parameter>
+                      <Parameter id="NjOFnGNXbUSppgUCLvVBFA" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.067256381" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="9B7XTDpmmkyR7W5SbUa4-g" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.015672726">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="ZIgHZjfZcEadJ-tfSdUQ2g" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.067256381" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="SrmiPdpcQkuxY-1Oc7iKyA" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.015672726">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="QsQUz71e30uh3XmGetJwgQ" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.00554" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <Parameter id="Y6vCZVjJ-EKmJfZYUQtUEQ" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0280138174" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <Parameter id="mAg-bkPnH0CCjqLY19W4DA" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.09106073" displayUnit="1/cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <DistributedParameter id="bJY5n4H1M06VV-J11bwB8w" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="D2dx9GneuE2ELgQOqoTHyA" mode="Logical" isDefault="1">
+                        <Children>
+                          <Parameter id="bkxAyXtBnEWuEsb80H_V7g" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="32" group="32" />
+                          </Parameter>
+                          <Parameter id="wLAEARPlGUyoqdONiqcS-A" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.5">
+                            <Info min="0" flag="50" seq="1" ref="0" bb="32" group="32" />
+                          </Parameter>
+                        </Children>
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="122" seq="1" ref="0" bb="32" group="32" />
+                      </DistributedParameter>
+                      <Container id="bVV3EG182EW5Ar4iHiRFCA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
+                        <Children>
+                          <Parameter id="_wq68o1fXkyv5vq9g9cNhw" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="sAgLzzcSbU-Lro2PDBo-zw" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                          </Parameter>
+                          <Parameter id="MeUm58GgG0yyCdKw-RIsaQ" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" rHSFormula="CbHBIDCd9UCPiyObpHz4Qg" value="0" displayUnit="µmol">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Parameter id="nN6s2fmz70KNeyQSz3m4Hw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                          </Parameter>
+                          <Parameter id="S25iEdbpPkqp7E72czB-QQ" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="pLyHG64fYUuuwJbDRsgYXQ" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="mIWCYQtM-0agjvEqt34C7Q" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="jnFn0dVW_UuaZKn4VZQsbw" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="twBfGIffWEqsWWd9yRB1eQ" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IQoV9Bf6fEeClxkhrWQndA" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="wwpb8uuj2E-zPvnZN13w7A" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="4y77xOcuwUu3mD-0abcfTw" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="goDNZ4o6u0-Fw2KBdhZWFQ" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="HGw1h1qmUUaU5u59svvqag" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="AUTT7-IodEa6frqK4dNq7g" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="D-O5q7FU9kGs7Oj13xfQWQ" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="12QnXhUbvEyiZLqBZDfmsg" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="KL0CMa-gw0eRoTHybxaRuA" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="2C2tbxyyyUyWmxJRHD20gQ" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IKKvq7FNH0WVqLL1WlK98g" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="1HPi4TZ8P06MikLYmqEH-Q" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="PTWduXcrQE6TuiaHRV7EEQ" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="T3rgxH_dA0WEWK9PDYo0oA" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cs_aXu3q5EC0C6PdBucAFw" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="VZadVAZniUeEwin9pbt5NA" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="mHb-SliHRUiy2nu8AVrlRg" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="XwdQBwO3Ckqz59OerJQNLw" name="Solubility" description="Solubility" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="iRY4N1Pqn0W2jBOrCG0ptg" isDefault="1" displayUnit="mg/l">
+                            <Info min="0" flag="122" seq="1" ref="0" bb="2" group="42" />
+                          </Parameter>
+                          <Parameter id="iRlVe4PGO0-ySDn3NCH_OA" name="Solubility table" description="Solubility table" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="sPp7vgPS5EaDrVIJGaPr-Q" isDefault="1" displayUnit="mg/l">
+                            <Info min="0" flag="50" seq="1" ref="0" bb="2" group="42" />
+                          </Parameter>
+                          <Parameter id="Xar7scd72UeHMesCzWYEEg" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="laSZo7Mr50SoKS70JH3d2Q" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="TPCcs4TZbUOh27gkAP8-2g" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="YQERj92sg0eOeddA3tJEnw" isDefault="1" displayUnit="min">
+                            <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="vuhqkS0G00eoilPd2Z-Uwg" name="Effective concentration in lumen" description="In case of supersaturation: molecule amount divided by liquid volume. Otherwise: Min(intestinal solubility; molecule amount divided by liquid volume)." icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="MjUWb6J9o0C-1UWLMLGCqw" isDefault="1" displayUnit="µmol/l">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="42" />
+                          </Parameter>
+                        </Children>
+                      </Container>
+                    </Children>
+                  </Container>
+                  <Container id="DdIHOXwYBUCq93VVa5oJ7g" name="ColonTransversum" description="Colon Transversum" icon="ColonTransversum" mode="Physical" containerType="Compartment">
+                    <Tags>
+                      <Tag value="Lumen" />
+                      <Tag value="LumenSegment" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="71uninUipEu8iDqX1ZCRQw" name="Absorption of liquid" description="rate of liquid outflow" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="kaRDWceerUqXWaP-qgl_Zw" isDefault="1" displayUnit="1/min">
+                        <Info flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="GgKD0igvWEaP2aaynMjmeQ" name="Distal radius" description="Distal radius of intestinal segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="p-ifWBsgtkCYNe8r-x0_mQ" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="JVc7-LblJEqRYnRtZElmmg" name="Effective surface area" description="Effective surface area of GI segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="ycPdUcIp5EKqELapSr2u-w" isDefault="1" displayUnit="cm²">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
+                        <Info min="0" flag="52" seq="1" ref="0" bb="32" group="33" />
+                      </Parameter>
+                      <Parameter id="5evcBvgYpU2skUrZynteeQ" name="FillLevelFlag" description="Fill Level Flag" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="7HeksdzzjUeQj7kX8vDHbg" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="BORAIfbffkaS-MDmuwWVPQ" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="1idWGEaDeE2qn5k830utxA" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="qA6DLANrzE-D2yOknvM-Dg" name="Geometric surface area" description="Geometric surface area of GI segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="c4Zv_ty3ZEOIEkFTsiKx8A" isDefault="1" displayUnit="cm²">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="62" seq="1" ref="0" bb="32" group="33" />
+                      </Parameter>
+                      <Parameter id="U1DFkjIAak2Nv_vMRGkHoA" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="mEVcDlLaEUyG_BDTgYh8SA" isDefault="1" displayUnit="1/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="oVXFDtzJF0eHFNQvS7dbRw" name="Length" description="Length" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="-nYOr4fSp0GX3ocYyuhcOw" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="106" seq="1" ref="0" bb="32" group="34" />
+                      </Parameter>
+                      <Parameter id="3rTnpikd5k6qmGbrfr5r4A" name="Liquid" description="Liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="N0wzZBKIDkiUKbOSRMr88w" isDefault="1" rHSFormula="RELbaq49qUGJXrbr3kuQOw" displayUnit="l">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="xsZTKvAKGkGMA-KbTdpECw" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="g19pbO_laECIzd7DRmXOdg" isDefault="1" displayUnit="l/min">
+                        <Info flag="52" seq="1" ref="0" bb="2" group="39" />
+                      </Parameter>
+                      <Parameter id="jwXB4uIZt0GwOpICrFulUA" name="Proximal radius" description="Proximal radius of intestinal segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="68xm_j1F_kadz1plb4Humw" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="WHfBPWcr6Ui4kzDtxlR9vg" name="Secretion of liquid" description="Rate of liquid inflow" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="WKCAKX2wNkmDbywahi79jg" isDefault="1" displayUnit="l/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="EalPbrtX00qeLKY2vtS5FQ" name="Thickness of gut wall" description="Thickness of Gut Wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Zhmtbn4PVkKNtMUGll4olg" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="38" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <Parameter id="d871lPrmKUm2PBppdV0AmA" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="WpAy5WPuG0WjdRWkmGKlHA" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="62" seq="1" ref="0" bb="2" group="56" />
+                      </Parameter>
+                      <Parameter id="_b50NlZ7hkukhSNyoyvlvg" name="Volume (gut wall)" description="Volume of the gut wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="5hePi0UqyE6Ygu16w_2Lkg" isDefault="1" displayUnit="l">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="62" seq="1" ref="0" bb="32" group="44" />
+                      </Parameter>
+                      <Parameter id="rgMhZmL8KEWPZZ6W-qDpjA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="jUuicTjwYECqpkpEHOcv6w" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="wUFggXpwe0e-PXEogo4ysw" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0060009">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="58" seq="1" ref="0" bb="32" group="43" />
+                      </Parameter>
+                      <Parameter id="oqihIC-idEOCuscKgyeNhQ" name="Intestinal transit rate" description="Transit rate along intestinal segments" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="3.3333" displayUnit="1/min">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="54" seq="1" ref="0" bb="32" group="46" />
+                      </Parameter>
+                      <Parameter id="jRUGsY9T3UKMvdBsqESOiQ" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.6886041141" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="34" />
+                      </Parameter>
+                      <Parameter id="gMGb6-9qYESSSOVb7F-UiQ" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.144607745">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="34" />
+                      </Parameter>
+                      <Parameter id="U0DvdnoggkKzIIB5c5gyLg" name="Microvilli factor" description="Microvilli factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="38" seq="1" ref="0" bb="32" group="33" />
+                      </Parameter>
+                      <Parameter id="h6UY2D7xLUKZyFbp9rbC1w" name="pH" description="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="5.7">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
+                        <Info min="0" max="14" flag="122" seq="1" ref="0" bb="32" group="41" />
+                      </Parameter>
+                      <Parameter id="E0WrSliKCUmGuHAJ2e-pEw" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.067256381" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="ZvHjeP26GUyb3Wt2yQbh1w" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.015672726">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="ULs5LMK8DkCSn2favFjOWA" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0384322177" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="Bzqs9GtiKkG3OGdvCaVO9Q" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.008955843">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="yYhQvqMZXE2AKiXgfbPE4w" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0076" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <Parameter id="hNvYj1mTYUWrwtCLlHtcgw" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0394956146" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <Parameter id="Yf1qaLVl0km_lfilaVQEIQ" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.08637087" displayUnit="1/cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <DistributedParameter id="T2MV8LvkYUm4p9-LdcQ8BQ" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DjdvDUqf9UC3Qid69zuZZw" mode="Logical" isDefault="1">
+                        <Children>
+                          <Parameter id="A0w80Uh7WkSxgY4UAectxQ" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="32" group="32" />
+                          </Parameter>
+                          <Parameter id="SHlVR9i-j0uQGbox4irs_Q" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.5">
+                            <Info min="0" flag="50" seq="1" ref="0" bb="32" group="32" />
+                          </Parameter>
+                        </Children>
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="122" seq="1" ref="0" bb="32" group="32" />
+                      </DistributedParameter>
+                      <Container id="4qkr0zXvuE2QranWp-cfpw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
+                        <Children>
+                          <Parameter id="4j3CKcvrJ0i_QsF2aYo59w" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="sAgLzzcSbU-Lro2PDBo-zw" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                          </Parameter>
+                          <Parameter id="h2sKmxAi1EWGBidWOfR7Mg" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" rHSFormula="tE6JJ0II20GjJxIWCo0Q_w" value="0" displayUnit="µmol">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Parameter id="JSknAsfcsUGNNkinndG_kg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                          </Parameter>
+                          <Parameter id="LHvm3XBotES5mzvoSoLmJQ" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="pLyHG64fYUuuwJbDRsgYXQ" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="oLlI4uB_uE-q42nnM5-5PA" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="jnFn0dVW_UuaZKn4VZQsbw" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="CoeDt-G0kUu50cWzyPVb7A" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IQoV9Bf6fEeClxkhrWQndA" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="OhDMiB8ZfUyJjO-5oC6bqg" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="4y77xOcuwUu3mD-0abcfTw" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="JE1aesGbNE-TeOjV4T18VQ" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="HGw1h1qmUUaU5u59svvqag" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="vShOYyapUku-uamsJn1MFQ" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="D-O5q7FU9kGs7Oj13xfQWQ" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="BYXJypexZkeZPt1xtk9bfw" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="KL0CMa-gw0eRoTHybxaRuA" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="8DVjJ6EXpkuXELl6sUGxKQ" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IKKvq7FNH0WVqLL1WlK98g" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="rOqmTQTcikS71rXwXLewVQ" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="PTWduXcrQE6TuiaHRV7EEQ" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="YUfHkmFA60W390jd1J1DgA" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cs_aXu3q5EC0C6PdBucAFw" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="rq9rzmTGcUSNcmR8GVO0TQ" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="mHb-SliHRUiy2nu8AVrlRg" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="DLpMB6LzTUaNQMxBrzaGuQ" name="Solubility" description="Solubility" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="iRY4N1Pqn0W2jBOrCG0ptg" isDefault="1" displayUnit="mg/l">
+                            <Info min="0" flag="122" seq="1" ref="0" bb="2" group="42" />
+                          </Parameter>
+                          <Parameter id="vb0h3yIQVUuJKPkNB3n6xQ" name="Solubility table" description="Solubility table" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="sPp7vgPS5EaDrVIJGaPr-Q" isDefault="1" displayUnit="mg/l">
+                            <Info min="0" flag="50" seq="1" ref="0" bb="2" group="42" />
+                          </Parameter>
+                          <Parameter id="X_UztYhCyk6keq_zsQVRdg" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="laSZo7Mr50SoKS70JH3d2Q" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="Ld_DxpV8C0C3wWXnjYY11w" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="YQERj92sg0eOeddA3tJEnw" isDefault="1" displayUnit="min">
+                            <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="7cLRM5H0x06P0GReZW3eiA" name="Effective concentration in lumen" description="In case of supersaturation: molecule amount divided by liquid volume. Otherwise: Min(intestinal solubility; molecule amount divided by liquid volume)." icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="MjUWb6J9o0C-1UWLMLGCqw" isDefault="1" displayUnit="µmol/l">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="42" />
+                          </Parameter>
+                        </Children>
+                      </Container>
+                    </Children>
+                  </Container>
+                  <Container id="ibG_MtDU_UeUGcopqh_FaQ" name="ColonDescendens" description="Colon Descendens / Distal Colon 1" icon="ColonDescendens" mode="Physical" containerType="Compartment">
+                    <Tags>
+                      <Tag value="Lumen" />
+                      <Tag value="LumenSegment" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="dc9ABO5uo0yZW6JaBnhlOw" name="Absorption of liquid" description="rate of liquid outflow" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="N4ZfBaP0bU-p4Pl3Ll_Yqw" isDefault="1" displayUnit="1/min">
+                        <Info flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="5zZjLdgPhUOkVt703R397g" name="Distal radius" description="Distal radius of intestinal segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="p-ifWBsgtkCYNe8r-x0_mQ" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="32YYA8-nE0W1PhOmSLhKZg" name="Effective surface area" description="Effective surface area of GI segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="ycPdUcIp5EKqELapSr2u-w" isDefault="1" displayUnit="cm²">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
+                        <Info min="0" flag="52" seq="1" ref="0" bb="32" group="33" />
+                      </Parameter>
+                      <Parameter id="Oio01w7MhEin05SoYIsBqA" name="FillLevelFlag" description="Fill Level Flag" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="7HeksdzzjUeQj7kX8vDHbg" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="Z5tx2-WASUeqwGoIM0htyg" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="1idWGEaDeE2qn5k830utxA" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="DmNzE6lWw0CnV__uQnVAqg" name="Geometric surface area" description="Geometric surface area of GI segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="c4Zv_ty3ZEOIEkFTsiKx8A" isDefault="1" displayUnit="cm²">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="62" seq="1" ref="0" bb="32" group="33" />
+                      </Parameter>
+                      <Parameter id="LJFjX2KhuEe90_rYUtVS4A" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="px_qW122EkCCS1Nz_R6apQ" isDefault="1" displayUnit="1/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="0NMDPnP510yR0-Qtj4QXHQ" name="Length" description="Length" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="-nYOr4fSp0GX3ocYyuhcOw" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="106" seq="1" ref="0" bb="32" group="34" />
+                      </Parameter>
+                      <Parameter id="bZdZ005WDEyg-HeUJd3S-g" name="Liquid" description="Liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="N0wzZBKIDkiUKbOSRMr88w" isDefault="1" rHSFormula="2QVqRHPbpk-fCyGdaepQvw" displayUnit="l">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="3ucgQhIACUSBQFHSH9LBOw" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="gRiD_7x45EiTKZ2w71cH1g" isDefault="1" displayUnit="l/min">
+                        <Info flag="52" seq="1" ref="0" bb="2" group="39" />
+                      </Parameter>
+                      <Parameter id="gjAkXZDLgEWJ6k6ayBpmtg" name="Proximal radius" description="Proximal radius of intestinal segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="68xm_j1F_kadz1plb4Humw" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="D4ni2KxrDEiFsHbYvYM61Q" name="Secretion of liquid" description="Rate of liquid inflow" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="kxBpcZGfcEGzcmmTT6XQeQ" isDefault="1" displayUnit="l/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="21Mqrad0ckqBuxDHR_Kd1A" name="Thickness of gut wall" description="Thickness of Gut Wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Zhmtbn4PVkKNtMUGll4olg" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="38" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <Parameter id="2XXuDdH5S0aGEmqTCSC_xA" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="WpAy5WPuG0WjdRWkmGKlHA" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="62" seq="1" ref="0" bb="2" group="56" />
+                      </Parameter>
+                      <Parameter id="iC-wDIP5lUSEuNWQLwKKTg" name="Volume (gut wall)" description="Volume of the gut wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="zKCZTaZMz0K5ME2MfwwBOQ" isDefault="1" displayUnit="l">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="62" seq="1" ref="0" bb="32" group="44" />
+                      </Parameter>
+                      <Parameter id="WDIcQ-ZnrUmH7loC5VErcQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="jUuicTjwYECqpkpEHOcv6w" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="fkOou3imy0CaVll-IARv3w" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0060009">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="58" seq="1" ref="0" bb="32" group="43" />
+                      </Parameter>
+                      <Parameter id="bsftuzkQX0y6rlYZBdtrKw" name="Intestinal transit rate" description="Transit rate along intestinal segments" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="5" displayUnit="1/min">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="54" seq="1" ref="0" bb="32" group="46" />
+                      </Parameter>
+                      <Parameter id="u6ar8DROE06jwx-WBBclwA" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.4227543951" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="34" />
+                      </Parameter>
+                      <Parameter id="eTi3icvE-Eyl2xvVQb-bsA" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.098514277">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="34" />
+                      </Parameter>
+                      <Parameter id="k4cBlCRBJk-oEQdxS325Vg" name="Microvilli factor" description="Microvilli factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="38" seq="1" ref="0" bb="32" group="33" />
+                      </Parameter>
+                      <Parameter id="TWAzmIbHmkS5P1xPf8fnwQ" name="pH" description="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="6.6">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
+                        <Info min="0" max="14" flag="122" seq="1" ref="0" bb="32" group="41" />
+                      </Parameter>
+                      <Parameter id="VdGA90BPLECyTcIGsBWbmA" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0384322177" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="oZWaxehqPUihYwNQsM7hlQ" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.008955843">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="1gaJMuZBxEuJnsmuhi0NyQ" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0384322177" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="fzh5yZBpqke3IwTJSmcZSA" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.008955843">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="nWmUUXpvW0OW7DYaO8snjw" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0118" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <Parameter id="3c3m_x8cGUiuDv8UAVw8Mg" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0601543776" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <Parameter id="o2eoIDv2aUOGkKvwqQBSbQ" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.08977747" displayUnit="1/cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <DistributedParameter id="ns-QRii3XkC2IliwPwAbkg" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="6Uhk-o_IHEyOKNB6yWfqjQ" mode="Logical" isDefault="1">
+                        <Children>
+                          <Parameter id="HlISvNOZPU6_WGyPkyJosA" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="32" group="32" />
+                          </Parameter>
+                          <Parameter id="7o4urv1MkE2AGuIEyzee_g" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.5">
+                            <Info min="0" flag="50" seq="1" ref="0" bb="32" group="32" />
+                          </Parameter>
+                        </Children>
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="122" seq="1" ref="0" bb="32" group="32" />
+                      </DistributedParameter>
+                      <Container id="EX9wwENXxkWeK_bp6DRDbg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
+                        <Children>
+                          <Parameter id="f3_0WpZVaUKE1s8gb1U-Cg" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="sAgLzzcSbU-Lro2PDBo-zw" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                          </Parameter>
+                          <Parameter id="jPInFa-BX0q-iWWmDhlNJQ" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" rHSFormula="QxPqChOxWESqUe5UyDSWZA" value="0" displayUnit="µmol">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Parameter id="lSmXXmH36UyY6SNZdCxrNQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                          </Parameter>
+                          <Parameter id="zSoNsHScAkWDAjIXx1BC3g" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="pLyHG64fYUuuwJbDRsgYXQ" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="HU5QMnyySEuCTGltSXZtSA" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="jnFn0dVW_UuaZKn4VZQsbw" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="ZmirzAGVikuEbu97sRpTgA" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IQoV9Bf6fEeClxkhrWQndA" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="SKry0EXDQ0Ca3e37Xv2v8w" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="4y77xOcuwUu3mD-0abcfTw" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="r1hwZC3pnkWIErRDLF8rTA" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="HGw1h1qmUUaU5u59svvqag" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="i9wc0n48e0S6T1tX5-SLuQ" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="D-O5q7FU9kGs7Oj13xfQWQ" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="VYBFKkmH5E-pDuTCxYiU1w" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="KL0CMa-gw0eRoTHybxaRuA" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="jA-4wG4GzUCz3YumB6b1xg" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IKKvq7FNH0WVqLL1WlK98g" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="cQ0fLHNCKUSSW7ZW9H6mfg" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="PTWduXcrQE6TuiaHRV7EEQ" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="AqNizPgtaE23TF4nlaAxHw" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cs_aXu3q5EC0C6PdBucAFw" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="rnLfdQhWlEOGyK4v2TmYgg" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="mHb-SliHRUiy2nu8AVrlRg" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="yiVJLITi1kqhwD031YMwqA" name="Solubility" description="Solubility" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="iRY4N1Pqn0W2jBOrCG0ptg" isDefault="1" displayUnit="mg/l">
+                            <Info min="0" flag="122" seq="1" ref="0" bb="2" group="42" />
+                          </Parameter>
+                          <Parameter id="irqKMS1Ah02uZv9MiPqKYw" name="Solubility table" description="Solubility table" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="sPp7vgPS5EaDrVIJGaPr-Q" isDefault="1" displayUnit="mg/l">
+                            <Info min="0" flag="50" seq="1" ref="0" bb="2" group="42" />
+                          </Parameter>
+                          <Parameter id="KcNXdtPFgkia353ypsu_qw" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="laSZo7Mr50SoKS70JH3d2Q" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="vAbKSJhXiEa0N2KwTbaMuQ" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="YQERj92sg0eOeddA3tJEnw" isDefault="1" displayUnit="min">
+                            <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="aTIVGy12kE-MxQnlgBmpBg" name="Effective concentration in lumen" description="In case of supersaturation: molecule amount divided by liquid volume. Otherwise: Min(intestinal solubility; molecule amount divided by liquid volume)." icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="MjUWb6J9o0C-1UWLMLGCqw" isDefault="1" displayUnit="µmol/l">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="42" />
+                          </Parameter>
+                        </Children>
+                      </Container>
+                    </Children>
+                  </Container>
+                  <Container id="sHZCByHK30-UYnBeZG7BKw" name="ColonSigmoid" description="Colon Sigmoid / Distal Colon 2" icon="ColonSigmoid" mode="Physical" containerType="Compartment">
+                    <Tags>
+                      <Tag value="Lumen" />
+                      <Tag value="LumenSegment" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="9iNFuCSHRkeGk-VDtSUb3w" name="Absorption of liquid" description="rate of liquid outflow" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="_NYTLA4Z9EqF_4Ey-92V1g" isDefault="1" displayUnit="1/min">
+                        <Info flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="lWd8uw2GfUynAHDQeVACaA" name="Distal radius" description="Distal radius of intestinal segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="p-ifWBsgtkCYNe8r-x0_mQ" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="I47axHYcwEiF8BoJDD4wIQ" name="Effective surface area" description="Effective surface area of GI segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="ycPdUcIp5EKqELapSr2u-w" isDefault="1" displayUnit="cm²">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
+                        <Info min="0" flag="52" seq="1" ref="0" bb="32" group="33" />
+                      </Parameter>
+                      <Parameter id="RgPczDsmJ0eNWCksIpsvgQ" name="FillLevelFlag" description="Fill Level Flag" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="7HeksdzzjUeQj7kX8vDHbg" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="Tu_g1ezJvU6hpmJdSEQa4A" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="1idWGEaDeE2qn5k830utxA" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="_eM0D97DkkivEoxm8dBSJg" name="Geometric surface area" description="Geometric surface area of GI segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="c4Zv_ty3ZEOIEkFTsiKx8A" isDefault="1" displayUnit="cm²">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="62" seq="1" ref="0" bb="32" group="33" />
+                      </Parameter>
+                      <Parameter id="-2e4qiTbN0iiUK1kboZwJg" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="ByGPV9JXx0aPWfyujly96Q" isDefault="1" displayUnit="1/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="DZvk8BTuzUqFwS_yccir1g" name="Length" description="Length" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="-nYOr4fSp0GX3ocYyuhcOw" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="106" seq="1" ref="0" bb="32" group="34" />
+                      </Parameter>
+                      <Parameter id="b2ti_LtbakWO1g6i4ZLvvQ" name="Liquid" description="Liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="N0wzZBKIDkiUKbOSRMr88w" isDefault="1" rHSFormula="pVrB4n2orkeZo884nOsnzQ" displayUnit="l">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="MmfOzAOlJ0mxMRH9fc6ufA" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="wjvuZK2IikWXh8-tLT2QfQ" isDefault="1" displayUnit="l/min">
+                        <Info flag="52" seq="1" ref="0" bb="2" group="39" />
+                      </Parameter>
+                      <Parameter id="ENysXkbQSkacLtGAuy_nfQ" name="Proximal radius" description="Proximal radius of intestinal segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="68xm_j1F_kadz1plb4Humw" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="9EFQzbiumUSlT0JQrVCdzQ" name="Secretion of liquid" description="Rate of liquid inflow" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="fLYIYkz90UKr1KVsTab17w" isDefault="1" displayUnit="l/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="FCiBb1fAtECobIqMKU1Jqw" name="Thickness of gut wall" description="Thickness of Gut Wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Zhmtbn4PVkKNtMUGll4olg" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="38" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <Parameter id="9dAaImDIdU-DkCe_ejafsA" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="WpAy5WPuG0WjdRWkmGKlHA" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="62" seq="1" ref="0" bb="2" group="56" />
+                      </Parameter>
+                      <Parameter id="uZa5s0MGwkupYbwlbAnSAw" name="Volume (gut wall)" description="Volume of the gut wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="UA3XKc6iSkSbkyNGUHcV9w" isDefault="1" displayUnit="l">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="62" seq="1" ref="0" bb="32" group="44" />
+                      </Parameter>
+                      <Parameter id="Bq_z5yCh0EuG3QlPvCSEKQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="jUuicTjwYECqpkpEHOcv6w" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="qU_W6993zEKRI9G8ED-Spg" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0060009">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="58" seq="1" ref="0" bb="32" group="43" />
+                      </Parameter>
+                      <Parameter id="7SNjmzQogkGGru23YSvVBA" name="Intestinal transit rate" description="Transit rate along intestinal segments" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="4.0741" displayUnit="1/min">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="54" seq="1" ref="0" bb="32" group="46" />
+                      </Parameter>
+                      <Parameter id="zRG_QeZGtEmK8w_XuFHb9w" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5337898629" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="34" />
+                      </Parameter>
+                      <Parameter id="mK6guVj_jUSYYfvW2yw7Nw" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.121300709">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="34" />
+                      </Parameter>
+                      <Parameter id="b_MQvJDSyUei1wOURxPfcQ" name="Microvilli factor" description="Microvilli factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="38" seq="1" ref="0" bb="32" group="33" />
+                      </Parameter>
+                      <Parameter id="w7F4FEaNwEWjtsdgL6ckAg" name="pH" description="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="6.6">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
+                        <Info min="0" max="14" flag="122" seq="1" ref="0" bb="32" group="41" />
+                      </Parameter>
+                      <Parameter id="0y9zk52RpEyT4d6M8-JBWg" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0384322177" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="9DIl8hFnEkCMKhUFawUTow" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.008955843">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="DyXaStvw3ESmlcc7eAUEvQ" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0384322177" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="QJaHU73WhEygT-Sa2DZjlw" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.008955843">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="g7k6zDscBEWAqLUduMr7Qg" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.00536" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <Parameter id="KkiDpulzVkaXiG6yZYF0cQ" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0274432593" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <Parameter id="WvLSxtN7BEyG4Y8gNP8jGQ" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0889014" displayUnit="1/cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <DistributedParameter id="k1DvnHLbnEWguOmT4GZ0wQ" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="MiSGm5xytk-6RE4gu6-krg" mode="Logical" isDefault="1">
+                        <Children>
+                          <Parameter id="wxTpIeLJcUaB0oBmBAy6NA" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="32" group="32" />
+                          </Parameter>
+                          <Parameter id="Hy2sxyooWUaCmZZ1LYPF6w" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.5">
+                            <Info min="0" flag="50" seq="1" ref="0" bb="32" group="32" />
+                          </Parameter>
+                        </Children>
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="122" seq="1" ref="0" bb="32" group="32" />
+                      </DistributedParameter>
+                      <Container id="ixAc4jr3fkGODf74Apor6w" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
+                        <Children>
+                          <Parameter id="OqxulR-UnUiITSp51jRBMw" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="sAgLzzcSbU-Lro2PDBo-zw" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                          </Parameter>
+                          <Parameter id="_bjiOkdXHk2uACPpi6iZsQ" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" rHSFormula="ubEQZdDX70KP_Q2t_IBukg" value="0" displayUnit="µmol">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Parameter id="vIolCkxVz0OjFow46hPcvw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                          </Parameter>
+                          <Parameter id="jw8wdN0fg0etFjmXreOdSw" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="pLyHG64fYUuuwJbDRsgYXQ" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="7dP2vxEXEkmPGU5BoG_n5w" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="jnFn0dVW_UuaZKn4VZQsbw" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="r_-3oaCUPECZ_nbTdB6nMA" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IQoV9Bf6fEeClxkhrWQndA" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="f3VdkRXAYESA2I66bQEpZQ" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="4y77xOcuwUu3mD-0abcfTw" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="h0VAbMMdt06MzukZUDvivQ" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="HGw1h1qmUUaU5u59svvqag" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="itJigNMpl0qMlW5ZKw-knQ" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="D-O5q7FU9kGs7Oj13xfQWQ" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="JErD4dsYgkSmrbzUwf-BcQ" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="KL0CMa-gw0eRoTHybxaRuA" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="221NW8lvoE6qvak5wR4BgA" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IKKvq7FNH0WVqLL1WlK98g" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="LuQCxsYbV0ORjXjKVApm_Q" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="PTWduXcrQE6TuiaHRV7EEQ" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="6_8hOurkHUKYgWlOK9kCIg" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cs_aXu3q5EC0C6PdBucAFw" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="1BFJDT33w0yoeY76_kaxDg" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="mHb-SliHRUiy2nu8AVrlRg" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="F5eUwieDW0WK6jv3XwCeGg" name="Solubility" description="Solubility" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="iRY4N1Pqn0W2jBOrCG0ptg" isDefault="1" displayUnit="mg/l">
+                            <Info min="0" flag="122" seq="1" ref="0" bb="2" group="42" />
+                          </Parameter>
+                          <Parameter id="DSv7vXhdbE6tmqbppWYKug" name="Solubility table" description="Solubility table" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="sPp7vgPS5EaDrVIJGaPr-Q" isDefault="1" displayUnit="mg/l">
+                            <Info min="0" flag="50" seq="1" ref="0" bb="2" group="42" />
+                          </Parameter>
+                          <Parameter id="nvYCdK9znU6KgxdIowEV1g" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="laSZo7Mr50SoKS70JH3d2Q" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="tQvS_wjyhEKvoCG9r6Nzpw" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="YQERj92sg0eOeddA3tJEnw" isDefault="1" displayUnit="min">
+                            <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="mxQGEeUF_UWLdBEMDpGxgQ" name="Effective concentration in lumen" description="In case of supersaturation: molecule amount divided by liquid volume. Otherwise: Min(intestinal solubility; molecule amount divided by liquid volume)." icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="MjUWb6J9o0C-1UWLMLGCqw" isDefault="1" displayUnit="µmol/l">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="42" />
+                          </Parameter>
+                        </Children>
+                      </Container>
+                    </Children>
+                  </Container>
+                  <Container id="WXUsQpIjG0WT7kojm5PhDg" name="Rectum" description="Rectum" icon="Rectum" mode="Physical" containerType="Compartment">
+                    <Tags>
+                      <Tag value="Lumen" />
+                      <Tag value="LumenSegment" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="drL_lnyR1ki3LPfj2OlqYA" name="Absorption of liquid" description="rate of liquid outflow" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="j2zBPMNj2UyPphylX_iJsw" isDefault="1" displayUnit="1/min">
+                        <Info flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="QZyYuwvKQkuzda2xTfqBYw" name="Distal radius" description="Distal radius of intestinal segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="p-ifWBsgtkCYNe8r-x0_mQ" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="SK7Vyt674E-lz0dZT-F0Sg" name="Effective surface area" description="Effective surface area of GI segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="ycPdUcIp5EKqELapSr2u-w" isDefault="1" displayUnit="cm²">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
+                        <Info min="0" flag="52" seq="1" ref="0" bb="32" group="33" />
+                      </Parameter>
+                      <Parameter id="c7b9Gn2t9kuNVE6Lg5tPGQ" name="FillLevelFlag" description="Fill Level Flag" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="7HeksdzzjUeQj7kX8vDHbg" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="arQ5Xq0rAEujhahlcS7hKw" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="1idWGEaDeE2qn5k830utxA" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="tYSHf-0_OEKUXfTCXqs59w" name="Geometric surface area" description="Geometric surface area of GI segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="c4Zv_ty3ZEOIEkFTsiKx8A" isDefault="1" displayUnit="cm²">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="62" seq="1" ref="0" bb="32" group="33" />
+                      </Parameter>
+                      <Parameter id="RII02L5NQke7ltEP64l58g" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="ZoJ7916bgk-CCc3Q9yMNJg" isDefault="1" displayUnit="1/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="oRW5TtYg_kiHupeQGl3DgQ" name="Length" description="Length" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="-nYOr4fSp0GX3ocYyuhcOw" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="106" seq="1" ref="0" bb="32" group="34" />
+                      </Parameter>
+                      <Parameter id="O928WO2r9kuN-_7uck52Iw" name="Liquid" description="Liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="N0wzZBKIDkiUKbOSRMr88w" isDefault="1" rHSFormula="8wQlrsXdfkW-Ex6bAsDELw" displayUnit="l">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="rx9LvACfnU-AKuNIEEcm5g" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="fPauJ0fLpk61w78HrNm4RQ" isDefault="1" displayUnit="l/min">
+                        <Info flag="52" seq="1" ref="0" bb="2" group="39" />
+                      </Parameter>
+                      <Parameter id="m4bB5O4oxkGIY_S5yGfehg" name="Proximal radius" description="Proximal radius of intestinal segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="68xm_j1F_kadz1plb4Humw" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="L--V8uYFKE-PaP8ZP9cK_g" name="Secretion of liquid" description="Rate of liquid inflow" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="FtWKNu337U6d26aH9-SVnA" isDefault="1" displayUnit="l/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="YcK7gBjnEUWG_L5lGiYsHw" name="Thickness of gut wall" description="Thickness of Gut Wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Zhmtbn4PVkKNtMUGll4olg" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="38" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <Parameter id="uRMnaDkFXEyfN83X-ii3MA" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="WpAy5WPuG0WjdRWkmGKlHA" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="62" seq="1" ref="0" bb="2" group="56" />
+                      </Parameter>
+                      <Parameter id="WZFKs4nP2EqKYyyMvqR3FA" name="Volume (gut wall)" description="Volume of the gut wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="4aipDQ1MVE-V-2yyaX3Q9g" isDefault="1" displayUnit="l">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="62" seq="1" ref="0" bb="32" group="44" />
+                      </Parameter>
+                      <Parameter id="f9f3g6x4YEas1Jx1_8QbVw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="jUuicTjwYECqpkpEHOcv6w" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="Al2kSZNqe0-QOKgMlVsu2A" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0060009">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="58" seq="1" ref="0" bb="32" group="43" />
+                      </Parameter>
+                      <Parameter id="VKPHo1lr6EOTYhhBB_Yi4Q" name="Intestinal transit rate" description="Transit rate along intestinal segments" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="315.618" displayUnit="1/min">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="54" seq="1" ref="0" bb="32" group="46" />
+                      </Parameter>
+                      <Parameter id="eRAR3KVgR0KMTkgaAjVS5w" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.1569046761" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="34" />
+                      </Parameter>
+                      <Parameter id="EGiD7OPOLUWJYJghvo2z7g" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.052420808">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="34" />
+                      </Parameter>
+                      <Parameter id="tOpjNEjO-kuQgXAvEulmWw" name="Microvilli factor" description="Microvilli factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="38" seq="1" ref="0" bb="32" group="33" />
+                      </Parameter>
+                      <Parameter id="q74DGOEFfkq8DmBaHsl7VQ" name="pH" description="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="6.6">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
+                        <Info min="0" max="14" flag="122" seq="1" ref="0" bb="32" group="41" />
+                      </Parameter>
+                      <Parameter id="uex90fAna0KfnIW14F6qdA" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0384322177" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="nIj7dflOO06DuiiruzsmMg" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.008955843">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="GUOlAvY5fEWs63ZzUB8M4g" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0240201361" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="R2FKvOGdi0eMW78G8x2b9Q" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.005597402">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="APy5GsoDE0KGRLnMHol2vw" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.00665" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <Parameter id="NKAxuUaNiEi26JK2fLzlRg" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0324721331" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <Parameter id="gwKmBTkpv0WOPHC6twjlog" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.10014267" displayUnit="1/cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <DistributedParameter id="3YoBnFXeS0O3Vyu9Fm5VxQ" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="kS3acwwBak--bQmoL3MyGQ" mode="Logical" isDefault="1">
+                        <Children>
+                          <Parameter id="RVBVzYQ550uJx5AekzRFSw" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="32" group="32" />
+                          </Parameter>
+                          <Parameter id="MISM7hyYwEixIHVciYaNzA" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="3.56">
+                            <Info min="0" flag="50" seq="1" ref="0" bb="32" group="32" />
+                          </Parameter>
+                        </Children>
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="122" seq="1" ref="0" bb="32" group="32" />
+                      </DistributedParameter>
+                      <Container id="IeeZ5ru1Hk-oO6PqKrseIQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
+                        <Children>
+                          <Parameter id="aB79GrKk9EeRS11OHGrH1w" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="sAgLzzcSbU-Lro2PDBo-zw" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                          </Parameter>
+                          <Parameter id="B8liE_rvikGgOO1vMc_-uw" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" rHSFormula="t_nq58p5mkqNK8PHGafw9A" value="0" displayUnit="µmol">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Parameter id="UvDlKBIRHEesIj2LTDflFw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                          </Parameter>
+                          <Parameter id="e1RFc00BMkGOHuSiEa2GSw" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="pLyHG64fYUuuwJbDRsgYXQ" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="XmEAEDzgNUKSwe4v9zkp2A" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="jnFn0dVW_UuaZKn4VZQsbw" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="KSFcHNrGhk-RlyXhSyUcHg" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IQoV9Bf6fEeClxkhrWQndA" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="IJZus9f8V0mbeYjA7OxWWw" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="4y77xOcuwUu3mD-0abcfTw" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="N2y1DLus3Uutk6tvOgHeeg" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="HGw1h1qmUUaU5u59svvqag" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="HM2eLFMD1Uejoz-0yejyHQ" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="D-O5q7FU9kGs7Oj13xfQWQ" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="15Uo5041rkmkFoTHce3ivg" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="KL0CMa-gw0eRoTHybxaRuA" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="dgawhZs3eEGL61EQKBG-Hw" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IKKvq7FNH0WVqLL1WlK98g" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="sAH74-YrE0WaC5TM-H185A" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="PTWduXcrQE6TuiaHRV7EEQ" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="23E8JDPcdEys6LL0-t2E3A" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cs_aXu3q5EC0C6PdBucAFw" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="5uDgOjaZtEiKLVpPqeugkw" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="mHb-SliHRUiy2nu8AVrlRg" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="et1rkOfUAkicUvvcJg4fcQ" name="Solubility" description="Solubility" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="iRY4N1Pqn0W2jBOrCG0ptg" isDefault="1" displayUnit="mg/l">
+                            <Info min="0" flag="122" seq="1" ref="0" bb="2" group="42" />
+                          </Parameter>
+                          <Parameter id="Y7IoOZQiIEu5B89XeAUeOg" name="Solubility table" description="Solubility table" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="sPp7vgPS5EaDrVIJGaPr-Q" isDefault="1" displayUnit="mg/l">
+                            <Info min="0" flag="50" seq="1" ref="0" bb="2" group="42" />
+                          </Parameter>
+                          <Parameter id="imVpGRFTNkWrlYsjnnKGQw" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="laSZo7Mr50SoKS70JH3d2Q" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="LDHHVcD4FUiWCrzm3XLvxg" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="YQERj92sg0eOeddA3tJEnw" isDefault="1" displayUnit="min">
+                            <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="LnOxutNOIUWh52Qv8k_XHA" name="Effective concentration in lumen" description="In case of supersaturation: molecule amount divided by liquid volume. Otherwise: Min(intestinal solubility; molecule amount divided by liquid volume)." icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="MjUWb6J9o0C-1UWLMLGCqw" isDefault="1" displayUnit="µmol/l">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="42" />
+                          </Parameter>
+                        </Children>
+                      </Container>
+                    </Children>
+                  </Container>
+                  <Container id="o0KEj_vMWUWC2aTyBZvYmg" name="Feces" description="Feces compartment used to collect the fraction excreted of the compound from the instestinal wall into the gut lumen." mode="Physical" containerType="Compartment">
+                    <Tags>
+                      <Tag value="Lumen" />
+                      <Tag value="LumenSegment" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="9BZgLWtQxUq7dTtd88oP8g" name="Liquid" description="Liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" rHSFormula="6lMdeiwK8UGD1vZDTRYWIg" value="0" displayUnit="l">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="uWtKdeGHwk-PmRzWs3dUhg" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="l">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="56" />
+                      </Parameter>
+                    </Children>
+                  </Container>
+                </Children>
+              </Container>
+              <Container id="rX2poSWbvki6wnLlavD7QA" name="Stomach" description="Stomach" icon="Stomach" mode="Logical" containerType="Organ">
+                <Tags>
+                  <Tag value="Portal Vein Supplying Organ" />
+                  <Tag value="TissueOrgan" />
+                </Tags>
+                <Children>
+                  <Parameter id="Ey8lGbdzQkSNPEG1-8PlBg" name="Weight (tissue)" description="Weight of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="wccWBS9A2kuoeEsL1_z2ww" isDefault="1" displayUnit="kg">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
+                  </Parameter>
+                  <Parameter id="fYK9BdxtqkW8ClUmMcezlg" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="_1qGrWaZQ0-mf9ujtwqKng" isDefault="1" displayUnit="l/min">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="14" ref="0" bb="32" group="27" />
+                  </Parameter>
+                  <Parameter id="p-dzedOoz0-HwCmmz9CrVg" name="Lymph flow rate" description="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="wo_Oqj188kKCGN911xCrEw" isDefault="1" displayUnit="l/min">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="14" ref="0" bb="32" group="58" />
+                  </Parameter>
+                  <Parameter id="cKI5a7ysG0yaUH3lUhIfsg" name="Volume (endothelium)" description="Volume of  vascular endothelium" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="zU_l_c4DsE-aU0ZJyePxJw" isDefault="1" displayUnit="l">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="62" seq="14" ref="0" bb="32" group="127" />
+                  </Parameter>
+                  <Parameter id="kvvEPsUYGkWtGRmmaH8ouw" name="Fraction intracellular" description="Fraction of intracellular space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ZxHXV_JusU-NQSlrOekb3w" isDefault="1">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="62" seq="43" ref="0" bb="32" group="64" />
+                  </Parameter>
+                  <Parameter id="nklqRoc9q0CcInbbIPMKlQ" name="Blood flow rate" description="Organ blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="kOPtX3xlRUyjlOOtEoP9Yg" isDefault="1" displayUnit="l/min">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="48" source="Other" description="Absolute value = specific value (i.e. value normalized to the volume of the organ) multiplied by the organ volume" />
+                    <Info min="0" flag="62" seq="262" ref="0" bb="32" group="5" />
+                  </Parameter>
+                  <Parameter id="Zn-Tb-975UGeIBRZlM-T1Q" name="Density (tissue)" description="Density of tissue" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="38" seq="1" ref="0" bb="32" group="21" />
+                  </Parameter>
+                  <Parameter id="32W-YyHsYESLgbCEL01dfQ" name="Fluid recirculation flow proportionality factor" description="proportionality factor linking fluid recirculation flow to lymph flow via small pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.96">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="27" />
+                  </Parameter>
+                  <Parameter id="p9d3t4Xv8EyGY0rngKVy-Q" name="Lymph flow proportionality factor" description="Proportionality factor linking lymph flow to plasma flow" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.00204">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="58" />
+                  </Parameter>
+                  <Parameter id="8f6hmYfzok6gr384ccMqNA" name="Organ volume mouse" description="Organ volume mouse" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.00011" displayUnit="l">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="65" />
+                  </Parameter>
+                  <Parameter id="tsXzhGXhhkOdKSPAY3sZew" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.75">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0.75" max="0.75" flag="54" seq="1" ref="0" bb="32" group="2" />
+                  </Parameter>
+                  <Parameter id="vZyPpKesf0CLt8mx7frYlw" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="54" seq="1" ref="0" bb="32" group="94" />
+                  </Parameter>
+                  <Parameter id="ckKSRm7TyEuz1_wsOCff3g" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.05">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" max="1" flag="122" seq="14" ref="0" bb="32" group="114" />
+                  </Parameter>
+                  <Parameter id="uj-MNT161UGwvxD8qKwxIQ" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" icon="Parameter" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="3.97222222222222E-11" displayUnit="ml/min/N">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="14" ref="0" bb="32" group="115" />
+                  </Parameter>
+                  <Parameter id="Y1uDQ3nODk-8d-uNJ4Sj_Q" name="Radius (large pores)" description="Large endothelial pores radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.5E-07" displayUnit="µm">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="14" ref="0" bb="32" group="55" />
+                  </Parameter>
+                  <Parameter id="wRgNNd4Phky_KHf9WPGHvg" name="Radius (small pores)" description="Small endothelial pores radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="4.5E-08" displayUnit="µm">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="14" ref="0" bb="32" group="99" />
+                  </Parameter>
+                  <Parameter id="Yr7ji7PBS06K0nNF0V1zxg" name="Fraction vascular" description="Fraction of vascular space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.032">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="19" source="Publication" description="Kawai R, Lemaire M, Steimer JL, Bruelisauer A, Niederberger W, Rowland M. Physiologically based pharmacokinetic study on a cyclosporin derivative, SDZ IMM 125. J Pharmacokinet Biopharm. 1994 Oct;22(5):327-65." />
+                    <Info min="0" max="1" flag="62" seq="42" ref="0" bb="32" group="64" />
+                  </Parameter>
+                  <Parameter id="_9QmUAcNi0agaEQuD38OWQ" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.062">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
+                    <Info min="0" max="1" flag="122" seq="42" ref="0" bb="32" group="85" />
+                  </Parameter>
+                  <Parameter id="r2QzXnN0w0eM3fWUyqNBtg" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0487">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="42" ref="0" bb="32" group="86" />
+                  </Parameter>
+                  <Parameter id="y_glTsPcY0OKpae7ZHgR5w" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0163">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="43" ref="0" bb="32" group="86" />
+                  </Parameter>
+                  <Parameter id="lUZNEpZgukyWY5UM63YYNw" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.133">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
+                    <Info min="0" max="1" flag="122" seq="43" ref="0" bb="32" group="85" />
+                  </Parameter>
+                  <Parameter id="31wVsWAYNE6GJa-8a8oRfg" name="Fraction interstitial" description="Fraction of interstitial space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.1">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="19" source="Publication" description="Kawai R, Lemaire M, Steimer JL, Bruelisauer A, Niederberger W, Rowland M. Physiologically based pharmacokinetic study on a cyclosporin derivative, SDZ IMM 125. J Pharmacokinet Biopharm. 1994 Oct;22(5):327-65." />
+                    <Info min="0" max="1" flag="62" seq="44" ref="0" bb="32" group="64" />
+                  </Parameter>
+                  <Parameter id="DkuFcolUl0SlL7YTO5gV7A" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.158">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="22" source="Publication" description="Rodgers T, Rowland M. Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J Pharm Sci. 2006 Jun;95(6):1238-57 https://doi.org/10.1002/jps.20502" />
+                    <Info min="0" max="1" flag="122" seq="44" ref="0" bb="32" group="111" />
+                  </Parameter>
+                  <Parameter id="wXOe3M82O0W3zdVotwrqHA" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="24" source="Publication" description="POULIN P, THEIL F. Prediction of Pharmacokinetics Prior to In Vivo Studies. 1. Mechanism-Based Prediction of Volume of Distribution. JOURNAL OF PHARMACEUTICAL SCIENCES, VOL. 91, NO. 1, JANUARY 2002" />
+                    <Info min="0" max="1" flag="122" seq="44" ref="0" bb="32" group="112" />
+                  </Parameter>
+                  <Parameter id="VCKWD27tLEa2wRbzRhWdbA" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.141">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="22" source="Publication" description="Rodgers T, Rowland M. Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J Pharm Sci. 2006 Jun;95(6):1238-57 https://doi.org/10.1002/jps.20502" />
+                    <Info min="0" max="1" flag="122" seq="44" ref="0" bb="32" group="113" />
+                  </Parameter>
+                  <Parameter id="ECS25ln2VEqK4uwGIY_Q7g" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.792">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
+                    <Info min="0" max="1" flag="122" seq="44" ref="0" bb="32" group="85" />
+                  </Parameter>
+                  <Parameter id="0pXfTNH2ikyU2o0ZHchqPQ" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.718">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="44" ref="0" bb="32" group="86" />
+                  </Parameter>
+                  <Parameter id="Te6AZD9fBEyVnLeCRBuKiQ" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0375">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="22" source="Publication" description="Rodgers T, Rowland M. Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J Pharm Sci. 2006 Jun;95(6):1238-57 https://doi.org/10.1002/jps.20502" />
+                    <Info min="0" max="1" flag="122" seq="70" ref="0" bb="32" group="92" />
+                  </Parameter>
+                  <Parameter id="7l0plL2GYk2iKLyZGJ4C6Q" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0483">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="70" ref="0" bb="32" group="95" />
+                  </Parameter>
+                  <Parameter id="SfGEJSNwY0SYHBYPoeBlKQ" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0124">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="22" source="Publication" description="Rodgers T, Rowland M. Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J Pharm Sci. 2006 Jun;95(6):1238-57 https://doi.org/10.1002/jps.20502" />
+                    <Info min="0" max="1" flag="122" seq="71" ref="0" bb="32" group="92" />
+                  </Parameter>
+                  <Parameter id="JFhSwz2i7k2GcPuG52tfXA" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0182">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="71" ref="0" bb="32" group="95" />
+                  </Parameter>
+                  <Parameter id="tqWttg1Dh0Gwy8SxXTZ2kA" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.282">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="21" source="Publication" description="Rodgers T, Leahy D, Rowland M. Physiologically based pharmacokinetic modeling 1: predicting the tissue distribution of moderate-to-strong bases. J Pharm Sci. 2005 Jun;94(6):1259-76. https://doi.org/10.1002/jps.20322" />
+                    <Info min="0" max="1" flag="122" seq="72" ref="0" bb="32" group="92" />
+                  </Parameter>
+                  <Parameter id="cIWBZBsYnUu9J-gQ95N5Rg" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.15">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="72" ref="0" bb="32" group="95" />
+                  </Parameter>
+                  <Parameter id="ifHkE5t8IUSagU3YoxCrkA" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.456">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="22" source="Publication" description="Rodgers T, Rowland M. Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J Pharm Sci. 2006 Jun;95(6):1238-57 https://doi.org/10.1002/jps.20502" />
+                    <Info min="0" max="1" flag="122" seq="73" ref="0" bb="32" group="92" />
+                  </Parameter>
+                  <Parameter id="1uhAw_bk3kyXfe8mhKOI0A" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.78">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="73" ref="0" bb="32" group="95" />
+                  </Parameter>
+                  <Parameter id="YGm1Nfod2UyZzzbuY5d9vg" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.41">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="21" source="Publication" description="Rodgers T, Leahy D, Rowland M. Physiologically based pharmacokinetic modeling 1: predicting the tissue distribution of moderate-to-strong bases. J Pharm Sci. 2005 Jun;94(6):1259-76. https://doi.org/10.1002/jps.20322" />
+                    <Info min="0" max="1000" flag="122" seq="74" ref="0" bb="32" group="92" />
+                  </Parameter>
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+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="74" ref="0" bb="32" group="95" />
+                  </Parameter>
+                  <DistributedParameter id="KaCdReE1IUyQGN-AMN-FnQ" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="7QEqCm4Chkm11cnAsL46eQ" mode="Logical" isDefault="1" displayUnit="l">
+                    <Children>
+                      <Parameter id="7J_gku7eNEuVJkAtfGiuCQ" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.500633682521338">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="65" />
+                      </Parameter>
+                      <Parameter id="Po0v9FHcAEuKDJJP-Mzdfg" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.16847666928" displayUnit="l">
+                        <Info min="0" flag="34" seq="1" ref="0" bb="32" group="65" />
+                      </Parameter>
+                      <Parameter id="8tIbPo-x5Ear_smjasuEjg" name="Deviation" description="Standard deviation of Normal distribution" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.025271500392" displayUnit="l">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="65" />
+                      </Parameter>
+                    </Children>
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
+                    <Info min="0" flag="106" seq="18" ref="0" bb="32" group="65" />
+                  </DistributedParameter>
+                  <DistributedParameter id="OtXlv1eh6EK3FXHEjp-9JQ" name="Specific blood flow rate" description="Blood flow rate normalized to the organ volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" formula="_jZzJFgPqEWM-QpMz8APFg" mode="Logical" isDefault="1" displayUnit="ml/min/100g organ">
+                    <Children>
+                      <Parameter id="5MX5k7FVMESx2WVig7G2jA" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="5" />
+                      </Parameter>
+                      <Parameter id="you8dplhCU-7tUiY1vJgYw" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.3861" displayUnit="ml/min/100g organ">
+                        <Info min="0" flag="50" seq="1" ref="0" bb="32" group="5" />
+                      </Parameter>
+                      <Parameter id="v0nhkO9hXkGMjRrEO5MFdg" name="Deviation" description="Standard deviation of Normal distribution" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.019305" displayUnit="ml/min/100g organ">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="5" />
+                      </Parameter>
+                    </Children>
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="40" source="Publication" description="Edginton, A.N., Schmitt, W. &amp; Willmann, S. Clin Pharmacokinet (2006) 45: 1013. https://doi.org/10.2165/00003088-200645100-00005" />
+                    <Info min="0" flag="122" seq="261" ref="0" bb="32" group="5" />
+                  </DistributedParameter>
+                  <Container id="gdyMOOU0gkaW4spE0BcIjA" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="Stomach" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="GF_J6UG-7USQSmUV_GyPfw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="jUuicTjwYECqpkpEHOcv6w" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="DX-MfRf8m0qjhZ8XTus_zg" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="2ErPZJcYvUyL3QogRRKmZg" isDefault="1" displayUnit="l">
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+                        <Info min="0" flag="62" seq="14" ref="0" bb="2" group="126" />
+                      </Parameter>
+                      <Container id="kpVI7YGHMU-GeTIk2tZL4w" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
+                        <Children>
+                          <Parameter id="vpeHAt_XTkubzow-ZkDX6Q" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_o63arufdk2PTQFsOiSkqg" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                          </Parameter>
+                          <Parameter id="Yz7_Qwy2ZE6FibbxzL0I0A" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="pDRD-WocckCSQtVxG1Keug" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                          </Parameter>
+                          <Parameter id="IcgZC50jhE-acBrVXPTYTg" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="3PTNCKfDA0yr8QD63uBncQ" isDefault="1" displayUnit="min">
+                            <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                        </Children>
+                      </Container>
+                    </Children>
+                  </Container>
+                  <Container id="zHyBX88dpUCaGtm-lIfGkA" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="Stomach" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="I9S4OdZbgEmwTVgmwheumQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="jUuicTjwYECqpkpEHOcv6w" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="LEHsK_waDkOc5Kd935Zj3g" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="V2_FdO3puUGekuCdqn4lGg" isDefault="1" displayUnit="l">
+                        <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                        <Info min="0" flag="62" seq="14" ref="0" bb="2" group="121" />
+                      </Parameter>
+                      <Container id="dq7rjmKb10q-R4vbwUbjyQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
+                        <Children>
+                          <Parameter id="UQlLdhjNikKSoWO-42IZdQ" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_o63arufdk2PTQFsOiSkqg" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                          </Parameter>
+                          <Parameter id="8IyU4ZI4AU-5ZPf2lg2tWA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_B4r1Pf9BEa0ce4IJUo7mA" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                          </Parameter>
+                          <Parameter id="WySj4X0fjkm5oPUggjwthQ" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="3PTNCKfDA0yr8QD63uBncQ" isDefault="1" displayUnit="min">
+                            <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                        </Children>
+                      </Container>
+                    </Children>
+                  </Container>
+                  <Container id="NcLdQmZ2c0Wg97SMqL1wjg" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="Stomach" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="D9oqWlZXkESCoXu0zIeu-Q" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="jUuicTjwYECqpkpEHOcv6w" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="KB-3E2UiDEqAvtTN1OhhOw" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="FsvYOeKl5kaJQ1JZ4JcXpg" isDefault="1" displayUnit="l">
+                        <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                        <Info min="0" flag="62" seq="14" ref="0" bb="2" group="124" />
+                      </Parameter>
+                      <Parameter id="f4FQfh6EQ0OKLIt-WeZupQ" name="pH" description="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="vNehtSpde0yreA4KgSiy2A" isDefault="1">
+                        <Tags>
+                          <Tag value="Portal Vein Supplying Organ" />
+                          <Tag value="Stomach" />
+                        </Tags>
+                        <Info min="0" max="14" flag="122" seq="44" ref="0" bb="32" group="84" />
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+                      <Container id="JHrfY79-c0OJmflqUA5SlA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
+                        <Children>
+                          <Parameter id="NfVvL7q9tEOWJxJ_lWwODQ" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_o63arufdk2PTQFsOiSkqg" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                          </Parameter>
+                          <Parameter id="ocuRGihoJkGudXnjgeJ29A" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DD8IUKX9-E6jwxb_EdFx8w" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
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+                          <Parameter id="yLOmf2i5YkG3fTUYOeDwsQ" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="3PTNCKfDA0yr8QD63uBncQ" isDefault="1" displayUnit="min">
+                            <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
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+                    </Children>
+                  </Container>
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+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="Stomach" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="cQMvQCJ3_kip020eGR3D8w" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="-ijMbq55KEWxwtKNegWm3g" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
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+                      <Parameter id="dyUnaP888kinA-i0rQTp0g" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="nGzrbq1s0U6FgEbhM3oFgQ" isDefault="1" displayUnit="l">
+                        <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                        <Info min="0" flag="62" seq="14" ref="0" bb="2" group="125" />
+                      </Parameter>
+                      <Parameter id="xrDxpiglV0OMmFnSSaLXHQ" name="pH" description="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.4">
+                        <Tags>
+                          <Tag value="Portal Vein Supplying Organ" />
+                          <Tag value="Stomach" />
+                        </Tags>
+                        <Info min="0" max="14" flag="122" seq="44" ref="0" bb="32" group="83" />
+                      </Parameter>
+                      <Container id="x1TKevYT-0Cd0ducJy1dyg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
+                        <Children>
+                          <Parameter id="guZPm8qO2km72YUx3bgfyg" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_o63arufdk2PTQFsOiSkqg" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                          </Parameter>
+                          <Parameter id="tK2iT_knc0GHXM_62nTKVg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ENdyyDzgOkiCrIGKzY6R-A" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                          </Parameter>
+                          <Parameter id="b-HCLdc4bUOkF_zfioqkfw" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="3PTNCKfDA0yr8QD63uBncQ" isDefault="1" displayUnit="min">
+                            <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
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+                      </Container>
+                    </Children>
+                  </Container>
+                </Children>
+              </Container>
+              <Container id="3v2tr2jNU0WgyuKN1fD23Q" name="SmallIntestine" description="SmallIntestine" icon="SmallIntestine" mode="Logical" containerType="Organ">
+                <Tags>
+                  <Tag value="Portal Vein Supplying Organ" />
+                  <Tag value="TissueOrgan" />
+                </Tags>
+                <Children>
+                  <Parameter id="rimfSBDRaUqa2swIP-w1uw" name="Small intestinal transit time factor" description="Small intestinal transit time factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="RaOlctBQKkmfWmU-8iYx9Q" isDefault="1">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="38" seq="1" ref="0" bb="32" group="46" />
+                  </Parameter>
+                  <Parameter id="_W6c1lZjB0ewe29-lQj_7g" name="Weight (tissue)" description="Weight of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="wccWBS9A2kuoeEsL1_z2ww" isDefault="1" displayUnit="kg">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
+                  </Parameter>
+                  <Parameter id="SV2doOXb6EeVpL_13WcGtw" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="C2ZRssi1wUyld-vysX5PEg" isDefault="1" displayUnit="l/min">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="62" seq="15" ref="0" bb="32" group="27" />
+                  </Parameter>
+                  <Parameter id="O4mwzpksTkahmd6hVQho1Q" name="Fluid recirculation flow rate (incl. mucosa)" description="Fluid recirculation flow rate between plasma and interstitial space (incl. mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="_1qGrWaZQ0-mf9ujtwqKng" isDefault="1" displayUnit="l/min">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
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+                    <Info min="0" flag="122" seq="15" ref="0" bb="32" group="27" />
+                  </Parameter>
+                  <Parameter id="PyJRCS3QwkeY51Lua69YWg" name="Lymph flow rate" description="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="C9MOp44KUkC8Og1w2K7mgw" isDefault="1" displayUnit="l/min">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
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+                    <Info min="0" flag="62" seq="15" ref="0" bb="32" group="58" />
+                  </Parameter>
+                  <Parameter id="xMHUPA_x1EyhRJMm5DngXw" name="Lymph flow rate (incl. mucosa)" description="Lymph flow rate (incl. mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="wo_Oqj188kKCGN911xCrEw" isDefault="1" displayUnit="l/min">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="15" ref="0" bb="32" group="58" />
+                  </Parameter>
+                  <Parameter id="g0C52nKOLkyFORlVAnqBmA" name="Volume (endothelium)" description="Volume of  vascular endothelium" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="GNLt_FmSmkq9uFD2yjCdgQ" isDefault="1" displayUnit="l">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="62" seq="15" ref="0" bb="32" group="127" />
+                  </Parameter>
+                  <Parameter id="bSXOcMD95kyVBR0kyiEGgQ" name="Fraction intracellular" description="Fraction of intracellular space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ZxHXV_JusU-NQSlrOekb3w" isDefault="1">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="62" seq="46" ref="0" bb="32" group="64" />
+                  </Parameter>
+                  <Parameter id="bjvZ0Qa12kabCWk5nbgQ-w" name="Blood flow rate" description="Organ blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="kOPtX3xlRUyjlOOtEoP9Yg" isDefault="1" displayUnit="l/min">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="48" source="Other" description="Absolute value = specific value (i.e. value normalized to the volume of the organ) multiplied by the organ volume" />
+                    <Info min="0" flag="62" seq="222" ref="0" bb="32" group="5" />
+                  </Parameter>
+                  <Parameter id="rcAbjQFYTUa4GuTJWneLJQ" name="Volume (mucosa)" description="Volume of mucosa" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="iszZ74Mnw0aSg3VMhD9y8g" isDefault="1" displayUnit="l">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="62" seq="666" ref="0" bb="32" group="129" />
+                  </Parameter>
+                  <Parameter id="zbV9433tIkmi7waWCNNUjA" name="Density (tissue)" description="Density of tissue" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="38" seq="1" ref="0" bb="32" group="21" />
+                  </Parameter>
+                  <Parameter id="uOM0debMWU6DyFJPNVpHCA" name="Fluid recirculation flow proportionality factor" description="proportionality factor linking fluid recirculation flow to lymph flow via small pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.179">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="27" />
+                  </Parameter>
+                  <Parameter id="TOQ7RSLTBUqpqKZaFNmDYw" name="Lymph flow proportionality factor" description="Proportionality factor linking lymph flow to plasma flow" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.00195">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="58" />
+                  </Parameter>
+                  <Parameter id="XfQkYTnFH0WbT0c7xlC8fw" name="Organ volume mouse" description="Organ volume mouse" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.001406" displayUnit="l">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="65" />
+                  </Parameter>
+                  <Parameter id="Q40QvgL8U0mawbNQiPb0jA" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.75">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0.75" max="0.75" flag="54" seq="1" ref="0" bb="32" group="2" />
+                  </Parameter>
+                  <Parameter id="-08FE49j_k263ghx6VautQ" name="Mucosa blood flow fraction" description="Blood fraction which goes to mucosa" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.75">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="39" />
+                  </Parameter>
+                  <Parameter id="W82qLy90WUa74MGgBsqdNA" name="Small intestinal transit time factor intercept" description="Small intestinal transit time factor intercept" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-4.52">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info flag="52" seq="1" ref="0" bb="32" group="46" />
+                  </Parameter>
+                  <Parameter id="Kn_abtdkp0etM-kuTfxkdA" name="Small intestinal transit time factor slope" description="Small intestinal transit time factor slope" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.602" displayUnit="1/min">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info flag="52" seq="1" ref="0" bb="32" group="46" />
+                  </Parameter>
+                  <Parameter id="dYakMcFCG0uCMW1jHcJIWw" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="54" seq="1" ref="0" bb="32" group="94" />
+                  </Parameter>
+                  <Parameter id="l5Ti_o-4gk64JTNLj9-uLA" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.05">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" max="1" flag="122" seq="15" ref="0" bb="32" group="114" />
+                  </Parameter>
+                  <Parameter id="bcDBlux-uUKYCjN4UZ806A" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" icon="Parameter" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.53888888888889E-10" displayUnit="ml/min/N">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="15" ref="0" bb="32" group="115" />
+                  </Parameter>
+                  <Parameter id="R4l4dPE9hkyPy0GNp_qfrw" name="Radius (large pores)" description="Large endothelial pores radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.5E-07" displayUnit="µm">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="15" ref="0" bb="32" group="55" />
+                  </Parameter>
+                  <Parameter id="kyndRa5mL0CCqXZLe8zvWw" name="Radius (small pores)" description="Small endothelial pores radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="4.5E-08" displayUnit="µm">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="15" ref="0" bb="32" group="99" />
+                  </Parameter>
+                  <Parameter id="Sn7kjybKy0CWSI7BeCpl8A" name="Fraction vascular" description="Fraction of vascular space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.024">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="19" source="Publication" description="Kawai R, Lemaire M, Steimer JL, Bruelisauer A, Niederberger W, Rowland M. Physiologically based pharmacokinetic study on a cyclosporin derivative, SDZ IMM 125. J Pharmacokinet Biopharm. 1994 Oct;22(5):327-65." />
+                    <Info min="0" max="1" flag="62" seq="45" ref="0" bb="32" group="64" />
+                  </Parameter>
+                  <Parameter id="Z4q6qd0TFkS1JhA2QQb5Yw" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.062">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
+                    <Info min="0" max="1" flag="122" seq="45" ref="0" bb="32" group="85" />
+                  </Parameter>
+                  <Parameter id="djGfh2oCPkyWBWmC8HuTzA" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0487">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="45" ref="0" bb="32" group="86" />
+                  </Parameter>
+                  <Parameter id="fDhVovtdjUuHQi2IO3_9vQ" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0163">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="46" ref="0" bb="32" group="86" />
+                  </Parameter>
+                  <Parameter id="PkY9zaAU9kuhzSh0lQic0Q" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.133">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
+                    <Info min="0" max="1" flag="122" seq="46" ref="0" bb="32" group="85" />
+                  </Parameter>
+                  <Parameter id="eaonMHEZoEGHi6QNJwBg5Q" name="Fraction interstitial" description="Fraction of interstitial space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.094">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="19" source="Publication" description="Kawai R, Lemaire M, Steimer JL, Bruelisauer A, Niederberger W, Rowland M. Physiologically based pharmacokinetic study on a cyclosporin derivative, SDZ IMM 125. J Pharmacokinet Biopharm. 1994 Oct;22(5):327-65." />
+                    <Info min="0" max="1" flag="62" seq="47" ref="0" bb="32" group="64" />
+                  </Parameter>
+                  <Parameter id="MC4-Kj3u90yl1fxPp66ClQ" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.158">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="22" source="Publication" description="Rodgers T, Rowland M. Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J Pharm Sci. 2006 Jun;95(6):1238-57 https://doi.org/10.1002/jps.20502" />
+                    <Info min="0" max="1" flag="122" seq="47" ref="0" bb="32" group="111" />
+                  </Parameter>
+                  <Parameter id="rFUnSjTGwkq3h6y6U391NA" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="24" source="Publication" description="POULIN P, THEIL F. Prediction of Pharmacokinetics Prior to In Vivo Studies. 1. Mechanism-Based Prediction of Volume of Distribution. JOURNAL OF PHARMACEUTICAL SCIENCES, VOL. 91, NO. 1, JANUARY 2002" />
+                    <Info min="0" max="1" flag="122" seq="47" ref="0" bb="32" group="112" />
+                  </Parameter>
+                  <Parameter id="3fX1ednBQkWIl-LhbWKOqw" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.141">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="22" source="Publication" description="Rodgers T, Rowland M. Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J Pharm Sci. 2006 Jun;95(6):1238-57 https://doi.org/10.1002/jps.20502" />
+                    <Info min="0" max="1" flag="122" seq="47" ref="0" bb="32" group="113" />
+                  </Parameter>
+                  <Parameter id="TqWF1Skowk2VFmetMcHaiw" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.792">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
+                    <Info min="0" max="1" flag="122" seq="47" ref="0" bb="32" group="85" />
+                  </Parameter>
+                  <Parameter id="AFmZtLeX7UmS8_Lck7s3Pg" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.718">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="47" ref="0" bb="32" group="86" />
+                  </Parameter>
+                  <Parameter id="WqzIKr300E6ZxcDQTHedQw" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0375">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="22" source="Publication" description="Rodgers T, Rowland M. Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J Pharm Sci. 2006 Jun;95(6):1238-57 https://doi.org/10.1002/jps.20502" />
+                    <Info min="0" max="1" flag="122" seq="75" ref="0" bb="32" group="92" />
+                  </Parameter>
+                  <Parameter id="lmd6KkeTZk6cE9KhtUrdYg" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0483">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="75" ref="0" bb="32" group="95" />
+                  </Parameter>
+                  <Parameter id="5PU3m65iikq3pwv9T_bb0w" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0124">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="22" source="Publication" description="Rodgers T, Rowland M. Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J Pharm Sci. 2006 Jun;95(6):1238-57 https://doi.org/10.1002/jps.20502" />
+                    <Info min="0" max="1" flag="122" seq="76" ref="0" bb="32" group="92" />
+                  </Parameter>
+                  <Parameter id="rT0jFF1rUE2GMzKfE4pWmA" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0182">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="76" ref="0" bb="32" group="95" />
+                  </Parameter>
+                  <Parameter id="Ck6lKCaAhUSf9W8QiDK8kA" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.282">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="21" source="Publication" description="Rodgers T, Leahy D, Rowland M. Physiologically based pharmacokinetic modeling 1: predicting the tissue distribution of moderate-to-strong bases. J Pharm Sci. 2005 Jun;94(6):1259-76. https://doi.org/10.1002/jps.20322" />
+                    <Info min="0" max="1" flag="122" seq="77" ref="0" bb="32" group="92" />
+                  </Parameter>
+                  <Parameter id="4hMiIt2eaESSpTFA6zlUXQ" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.15">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="77" ref="0" bb="32" group="95" />
+                  </Parameter>
+                  <Parameter id="38HN-Dm7c0-1ILEMGtpWeQ" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.456">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="22" source="Publication" description="Rodgers T, Rowland M. Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J Pharm Sci. 2006 Jun;95(6):1238-57 https://doi.org/10.1002/jps.20502" />
+                    <Info min="0" max="1" flag="122" seq="78" ref="0" bb="32" group="92" />
+                  </Parameter>
+                  <Parameter id="BVjsRAcDwEG1coyfiA4ZVA" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.78">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="78" ref="0" bb="32" group="95" />
+                  </Parameter>
+                  <Parameter id="9ZYOfJaC5UmPkPP6Ck6xkQ" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.41">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="21" source="Publication" description="Rodgers T, Leahy D, Rowland M. Physiologically based pharmacokinetic modeling 1: predicting the tissue distribution of moderate-to-strong bases. J Pharm Sci. 2005 Jun;94(6):1259-76. https://doi.org/10.1002/jps.20322" />
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+                          <Parameter id="4GYdH2NWC0WZicDbgzSj1Q" name="Fraction of regional blood flow rate" description="Regional blood flow fraction supplying the mucosal tissue of the segment" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.093">
+                            <Info min="0" flag="54" seq="1" ref="0" bb="32" group="39" />
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+                            <Info min="0" max="1" flag="54" seq="1" ref="0" bb="32" group="94" />
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+                          <Parameter id="bPLTvXX7MU2QxKI1TWXWvw" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.05">
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+                            <Info min="0" max="1" flag="122" seq="111" ref="0" bb="32" group="114" />
+                          </Parameter>
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+                          <Parameter id="iZqXg4wKiEGKOMkYlXV5Hw" name="Radius (large pores)" description="Large endothelial pores radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.5E-07" displayUnit="µm">
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+                            <Info min="0" flag="122" seq="111" ref="0" bb="32" group="99" />
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+                          <Parameter id="HfZKippGlkCVN3Opb9OSGQ" name="Fraction vascular" description="Fraction of vascular space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.13">
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+                          <Parameter id="aZdYlQbLHE-5QVVYKKtmNw" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.06">
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+                            <Info min="0" max="1" flag="122" seq="333" ref="0" bb="32" group="85" />
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+                            <Info min="0" max="1" flag="122" seq="333" ref="0" bb="32" group="86" />
+                          </Parameter>
+                          <Parameter id="MKUunH2lM0223-cfV-lUcg" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0163">
+                            <Info min="0" max="1" flag="122" seq="334" ref="0" bb="32" group="86" />
+                          </Parameter>
+                          <Parameter id="U9loPXJ4X0e9APrW4YrLNQ" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.08">
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+                          <Parameter id="coDettTMVE2xQ4vur78oqg" name="Fraction interstitial" description="Fraction of interstitial space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.42">
+                            <Info min="0" max="1" flag="62" seq="335" ref="0" bb="32" group="64" />
+                          </Parameter>
+                          <Parameter id="Gt9UjPTJaU2cWDwQ7TliWA" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.158">
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+                          <Parameter id="NeLD7goRVEik1p3puc7UPw" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
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+                          <Parameter id="mPA2inX5rkuUIsbyIeSpoQ" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.8">
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+                            <Info min="0" max="1" flag="122" seq="335" ref="0" bb="32" group="85" />
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+                          <Parameter id="Eogye7UKX0a6OCYm5DnEGg" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.718">
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+                          <Parameter id="SschKx41cE-B9Xog7TtM8Q" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.282">
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+                            <Info min="0" max="1" flag="122" seq="557" ref="0" bb="32" group="92" />
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+                          <Parameter id="0bKX5RaQfUOjm6Nj2CzQoA" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.15">
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+                          </Parameter>
+                          <Parameter id="8_hG3ROsTEieTMVVmrD34w" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.456">
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+                          </Parameter>
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+                            <Info min="0" max="1000" flag="122" seq="559" ref="0" bb="32" group="92" />
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+                              <Tag value="Mucosa" />
+                              <Tag value="SmallIntestineSegment" />
+                            </Tags>
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+                              <Parameter id="ey3cx53NkE-eyAn4iDZKPQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="jUuicTjwYECqpkpEHOcv6w" isDefault="1" displayUnit="l">
+                                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
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+                                <Info min="0" flag="62" seq="111" ref="0" bb="2" group="126" />
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+                                  <Parameter id="jMl4f4LJRUy4cqYTqNfc-Q" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_o63arufdk2PTQFsOiSkqg" isDefault="1">
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+                                  <Parameter id="DshSQ2shTkCVw4j5eO6GlQ" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="YQERj92sg0eOeddA3tJEnw" isDefault="1" displayUnit="min">
+                                    <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
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+                            <Tags>
+                              <Tag value="Duodenum" />
+                              <Tag value="Mucosa" />
+                              <Tag value="SmallIntestineSegment" />
+                            </Tags>
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+                              <Parameter id="Oh1o_tbc60iVYS0QaHxwbQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="jUuicTjwYECqpkpEHOcv6w" isDefault="1" displayUnit="l">
+                                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
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+                              <Parameter id="EScnPKUT1UWOi4zGQTj4nQ" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="V2_FdO3puUGekuCdqn4lGg" isDefault="1" displayUnit="l">
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+                              <Container id="uEMMzs3r80u7En64liymqA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
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+                                  <Parameter id="XWcq9-G8gUKUNhjFlBFDNA" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_o63arufdk2PTQFsOiSkqg" isDefault="1">
+                                    <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
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+                                  <Parameter id="56zt3w_TfEu6wgLQeu0Qqg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_B4r1Pf9BEa0ce4IJUo7mA" isDefault="1">
+                                    <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
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+                                  <Parameter id="oFiXk702okyQ-kjWcLmIYA" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="YQERj92sg0eOeddA3tJEnw" isDefault="1" displayUnit="min">
+                                    <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
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+                          <Container id="C7hTSXNAWUyi0kaAzMdxxg" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
+                            <Tags>
+                              <Tag value="Duodenum" />
+                              <Tag value="Mucosa" />
+                              <Tag value="SmallIntestineSegment" />
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+                              <Parameter id="QNBU2G3QjUaw7rDuokAZJg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="jUuicTjwYECqpkpEHOcv6w" isDefault="1" displayUnit="l">
+                                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
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+                              <Parameter id="yQLQI4DtRk6T4MWVTEbXwg" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="FsvYOeKl5kaJQ1JZ4JcXpg" isDefault="1" displayUnit="l">
+                                <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                                <Info min="0" flag="62" seq="111" ref="0" bb="2" group="124" />
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+                              <Parameter id="_lfVioRqBUuiIrbTuUQkMQ" name="pH" description="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="vNehtSpde0yreA4KgSiy2A" isDefault="1">
+                                <Tags>
+                                  <Tag value="Duodenum" />
+                                  <Tag value="Mucosa" />
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+                                <Info min="0" max="14" flag="122" seq="335" ref="0" bb="32" group="84" />
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+                                    <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
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+                                  <Parameter id="Pb05zbsQX0yY2eDr3Xr6sA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CFvv_rfWYEuXh5P9rqYSTw" isDefault="1">
+                                    <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
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+                                  <Parameter id="7KsUHsI96EyLIrNfrFOV1Q" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="YQERj92sg0eOeddA3tJEnw" isDefault="1" displayUnit="min">
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+                          <Container id="RAm9rDhc0E6uCneMFHfcSQ" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
+                            <Tags>
+                              <Tag value="Duodenum" />
+                              <Tag value="IntestinalSecretionSource" />
+                              <Tag value="Mucosa" />
+                              <Tag value="SmallIntestineSegment" />
+                            </Tags>
+                            <Children>
+                              <Parameter id="Qe76-xrblUyRWNlj53nIbQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="-ijMbq55KEWxwtKNegWm3g" isDefault="1" displayUnit="l">
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+                              <Parameter id="m5wWg2I6F0Gs8_DW7d7RPQ" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="nGzrbq1s0U6FgEbhM3oFgQ" isDefault="1" displayUnit="l">
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+                                <Tags>
+                                  <Tag value="Duodenum" />
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+                        <Children>
+                          <Parameter id="MN4wi0A-8EuuRiWeLfr0dw" name="Weight (tissue)" description="Weight of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="wccWBS9A2kuoeEsL1_z2ww" isDefault="1" displayUnit="kg">
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+                            <Info min="0" flag="62" seq="112" ref="0" bb="32" group="127" />
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+                          <Parameter id="hG2GnwECs0SZPbkWfaWsQg" name="Blood flow rate" description="Organ blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="-59WJ32EKk6Yd8JvyG1b8Q" isDefault="1" displayUnit="l/min">
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+                            <Info min="0" flag="122" seq="301" ref="0" bb="32" group="5" />
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+                          <Parameter id="pXsBap0NGUKl1MAdtt5CeA" name="Fraction intracellular" description="Fraction of intracellular space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ZxHXV_JusU-NQSlrOekb3w" isDefault="1">
+                            <Info min="0" max="1" flag="62" seq="337" ref="0" bb="32" group="64" />
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+                            <Info min="0" flag="38" seq="1" ref="0" bb="32" group="21" />
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+                          <Parameter id="yyocDDUxiUeVDYDrD4PkXA" name="Fraction mucosa" description="Mucosal fraction of regional intestinal tissue mass" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.26">
+                            <Info min="0" max="1" flag="122" seq="1" ref="0" bb="32" group="40" />
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+                          <Parameter id="SryvJCanZkqzf5l2Ga-4pA" name="Fraction of regional blood flow rate" description="Regional blood flow fraction supplying the mucosal tissue of the segment" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.219">
+                            <Info min="0" flag="54" seq="1" ref="0" bb="32" group="39" />
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+                            <Info min="0" max="1" flag="54" seq="1" ref="0" bb="32" group="94" />
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+                          <Parameter id="DsVgQRXS2kyRVRPPibCmBA" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.05">
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+                            <Info min="0" max="1" flag="122" seq="112" ref="0" bb="32" group="114" />
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+                          <Parameter id="rmmNfhaiq0SpbbPwe9IrtQ" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" icon="Parameter" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.53888888888889E-10" displayUnit="ml/min/N">
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+                            <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
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+                          <Parameter id="xBf55_QYpk21K2zhyrjxKg" name="Fraction vascular" description="Fraction of vascular space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.13">
+                            <Info min="0" max="1" flag="62" seq="336" ref="0" bb="32" group="64" />
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+                          <Parameter id="Qly3PE5iZkeXGHVb2PPopQ" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.06">
+                            <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
+                            <Info min="0" max="1" flag="122" seq="336" ref="0" bb="32" group="85" />
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+                          <Parameter id="CSI8JsfW0E6YQf80fZPxbw" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0487">
+                            <Info min="0" max="1" flag="122" seq="336" ref="0" bb="32" group="86" />
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+                          <Parameter id="NTN9mYrNuk-2TgOz2TwF4w" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0163">
+                            <Info min="0" max="1" flag="122" seq="337" ref="0" bb="32" group="86" />
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+                            <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
+                            <Info min="0" max="1" flag="122" seq="337" ref="0" bb="32" group="85" />
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+                          <Parameter id="ALbEYChWyUG7T7rj_byJnA" name="Fraction interstitial" description="Fraction of interstitial space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.35">
+                            <Info min="0" max="1" flag="62" seq="338" ref="0" bb="32" group="64" />
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+                          <Parameter id="Bii4uFbB4kW9oiX_G4vdoQ" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.158">
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+                          <Parameter id="XedhLCmGMU-KY4XAA_sUOA" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0375">
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+                          <Parameter id="UCUrCSDbrki9Kk_d3MSglQ" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0124">
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+                            <Info min="0" max="1" flag="122" seq="561" ref="0" bb="32" group="92" />
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+                          <Parameter id="lZNlJqqHX0yycfmaMm_Cig" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0182">
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+                          <Parameter id="GfM-3WLMNkWdu7QdXQXfqg" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.282">
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+                            <Info min="0" max="1" flag="122" seq="562" ref="0" bb="32" group="92" />
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+                          <Parameter id="3aS8g1qcSkG2K9TzxSZiEQ" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.15">
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+                          <Parameter id="233Eyuc9fUCZ5hHqX-jTlQ" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.456">
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+                            <Info min="0" max="1" flag="122" seq="563" ref="0" bb="32" group="92" />
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+                          <Parameter id="DL0k-T0ddU-2ZQv29Zlemg" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.78">
+                            <Info min="0" max="1" flag="122" seq="563" ref="0" bb="32" group="95" />
+                          </Parameter>
+                          <Parameter id="7aRksoI4lE-efv-8tX8R2g" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.41">
+                            <ValueOrigin id="21" source="Publication" description="Rodgers T, Leahy D, Rowland M. Physiologically based pharmacokinetic modeling 1: predicting the tissue distribution of moderate-to-strong bases. J Pharm Sci. 2005 Jun;94(6):1259-76. https://doi.org/10.1002/jps.20322" />
+                            <Info min="0" max="1000" flag="122" seq="564" ref="0" bb="32" group="92" />
+                          </Parameter>
+                          <Parameter id="KlVSds7-fE2w4VlXV-MjAA" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0035">
+                            <Info min="0" max="1" flag="122" seq="564" ref="0" bb="32" group="95" />
+                          </Parameter>
+                          <Container id="ZKtVpdVbAkeG3MsVGPjvZA" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
+                            <Tags>
+                              <Tag value="Mucosa" />
+                              <Tag value="SmallIntestineSegment" />
+                              <Tag value="UpperJejunum" />
+                            </Tags>
+                            <Children>
+                              <Parameter id="0Zt53E7NWkyP38QyIrUgKA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="jUuicTjwYECqpkpEHOcv6w" isDefault="1" displayUnit="l">
+                                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                              </Parameter>
+                              <Parameter id="zE28yFljHEqU6mzzmGOg_w" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="2ErPZJcYvUyL3QogRRKmZg" isDefault="1" displayUnit="l">
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+                                <Info min="0" flag="62" seq="112" ref="0" bb="2" group="126" />
+                              </Parameter>
+                              <Container id="cOofaoe5q0a-Hpl-XbC98A" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
+                                <Children>
+                                  <Parameter id="G-mJHRIty0GkDUX79Dy86Q" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_o63arufdk2PTQFsOiSkqg" isDefault="1">
+                                    <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                                  </Parameter>
+                                  <Parameter id="d47Dokbi-0CTn379aBtDbw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="pDRD-WocckCSQtVxG1Keug" isDefault="1">
+                                    <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                                  </Parameter>
+                                  <Parameter id="ohJ9Dt9uQESWzTa9sOHVdg" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="YQERj92sg0eOeddA3tJEnw" isDefault="1" displayUnit="min">
+                                    <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                                  </Parameter>
+                                </Children>
+                              </Container>
+                            </Children>
+                          </Container>
+                          <Container id="TE4MZUgC30mHln4P6rXnUg" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
+                            <Tags>
+                              <Tag value="Mucosa" />
+                              <Tag value="SmallIntestineSegment" />
+                              <Tag value="UpperJejunum" />
+                            </Tags>
+                            <Children>
+                              <Parameter id="ymR8bNjYCEGl96k7luB9zw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="jUuicTjwYECqpkpEHOcv6w" isDefault="1" displayUnit="l">
+                                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                              </Parameter>
+                              <Parameter id="vFSxvn1_DUKpXIRMReZgBg" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="V2_FdO3puUGekuCdqn4lGg" isDefault="1" displayUnit="l">
+                                <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                                <Info min="0" flag="62" seq="112" ref="0" bb="2" group="121" />
+                              </Parameter>
+                              <Container id="266NvjhMUEWencEs-Z1Bvw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
+                                <Children>
+                                  <Parameter id="JBoosJLW9Eq8jGtYhz7QPg" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_o63arufdk2PTQFsOiSkqg" isDefault="1">
+                                    <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                                  </Parameter>
+                                  <Parameter id="zC4paao5Aky_CnfJPy_Rxw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_B4r1Pf9BEa0ce4IJUo7mA" isDefault="1">
+                                    <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                                  </Parameter>
+                                  <Parameter id="ionl9Zv1XkC54VeBUI9JJw" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="YQERj92sg0eOeddA3tJEnw" isDefault="1" displayUnit="min">
+                                    <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                                  </Parameter>
+                                </Children>
+                              </Container>
+                            </Children>
+                          </Container>
+                          <Container id="v4S0FxtaWUa5mdhk99294A" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
+                            <Tags>
+                              <Tag value="Mucosa" />
+                              <Tag value="SmallIntestineSegment" />
+                              <Tag value="UpperJejunum" />
+                            </Tags>
+                            <Children>
+                              <Parameter id="kvVTETE8CEqqw0CwMdn8Jg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="jUuicTjwYECqpkpEHOcv6w" isDefault="1" displayUnit="l">
+                                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                              </Parameter>
+                              <Parameter id="7WTP13fzZU6i63z0wa4UsA" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="FsvYOeKl5kaJQ1JZ4JcXpg" isDefault="1" displayUnit="l">
+                                <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                                <Info min="0" flag="62" seq="112" ref="0" bb="2" group="124" />
+                              </Parameter>
+                              <Parameter id="X2xr7dgxBkGGf-m01T5hhA" name="pH" description="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="vNehtSpde0yreA4KgSiy2A" isDefault="1">
+                                <Tags>
+                                  <Tag value="Mucosa" />
+                                  <Tag value="SmallIntestineSegment" />
+                                  <Tag value="UpperJejunum" />
+                                </Tags>
+                                <Info min="0" max="14" flag="122" seq="338" ref="0" bb="32" group="84" />
+                              </Parameter>
+                              <Container id="mTHZyO0uWk2Ry3XybrB6hA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
+                                <Children>
+                                  <Parameter id="D_mtIBkjzUekkY2NcKIvBw" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_o63arufdk2PTQFsOiSkqg" isDefault="1">
+                                    <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                                  </Parameter>
+                                  <Parameter id="cR2rkJaVSUCYWfI75NoSjA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="tACvVGCMtU-8iV2V5Py4fA" isDefault="1">
+                                    <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                                  </Parameter>
+                                  <Parameter id="pY-JJlHVakS60fEn7PYC1A" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="YQERj92sg0eOeddA3tJEnw" isDefault="1" displayUnit="min">
+                                    <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                                  </Parameter>
+                                </Children>
+                              </Container>
+                            </Children>
+                          </Container>
+                          <Container id="-Du8nsEYSUmtfhASJQIGtA" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
+                            <Tags>
+                              <Tag value="IntestinalSecretionSource" />
+                              <Tag value="Mucosa" />
+                              <Tag value="SmallIntestineSegment" />
+                              <Tag value="UpperJejunum" />
+                            </Tags>
+                            <Children>
+                              <Parameter id="BPY9559P40i2kFOCPapSew" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="-ijMbq55KEWxwtKNegWm3g" isDefault="1" displayUnit="l">
+                                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                              </Parameter>
+                              <Parameter id="HmRuL9OxN0OrlCqc4F0I4Q" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="nGzrbq1s0U6FgEbhM3oFgQ" isDefault="1" displayUnit="l">
+                                <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                                <Info min="0" flag="62" seq="112" ref="0" bb="2" group="125" />
+                              </Parameter>
+                              <Parameter id="p6rWi_Co4EO4N5UbVq7S5w" name="pH" description="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.3">
+                                <Tags>
+                                  <Tag value="IntestinalSecretionSource" />
+                                  <Tag value="Mucosa" />
+                                  <Tag value="SmallIntestineSegment" />
+                                  <Tag value="UpperJejunum" />
+                                </Tags>
+                                <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
+                                <Info min="0" max="14" flag="122" seq="338" ref="0" bb="32" group="83" />
+                              </Parameter>
+                              <Container id="-f6nAeyv7UuXb64b0nCMTA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
+                                <Children>
+                                  <Parameter id="XvWgVFlKcku1_P05GlkBGQ" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_o63arufdk2PTQFsOiSkqg" isDefault="1">
+                                    <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                                  </Parameter>
+                                  <Parameter id="Mg2Y73m-gEu8i0AnzkzyRA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ueV1DN8oAEWGk_MZlSZ7qg" isDefault="1">
+                                    <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                                  </Parameter>
+                                  <Parameter id="nJTFXeoW402TEgrNrsY9cg" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="YQERj92sg0eOeddA3tJEnw" isDefault="1" displayUnit="min">
+                                    <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                                  </Parameter>
+                                </Children>
+                              </Container>
+                            </Children>
+                          </Container>
+                          <Container id="wEiU6SaTyU2EEC45MQ6Xew" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule" />
+                        </Children>
+                      </Container>
+                      <Container id="3wpEqACoAUGPLrCQO21YqA" name="LowerJejunum" description="Lower Jejunum" icon="LowerJejunum" mode="Logical" containerType="Compartment">
+                        <Children>
+                          <Parameter id="AlcTqtzftkSagEM0yKnbuQ" name="Weight (tissue)" description="Weight of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="wccWBS9A2kuoeEsL1_z2ww" isDefault="1" displayUnit="kg">
+                            <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
+                          </Parameter>
+                          <Parameter id="J3xVXKTFo0imb3ui-KOGOw" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="hiiK03XDtUCBOwpP5Gs1dQ" isDefault="1" displayUnit="l">
+                            <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
+                            <Info min="0" flag="122" seq="22" ref="0" bb="32" group="65" />
+                          </Parameter>
+                          <Parameter id="-cVvvIGtqEqiiWsBsv3SeQ" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="043DNcStI0-iJ7SmugQrkQ" isDefault="1" displayUnit="l/min">
+                            <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                            <Info min="0" flag="122" seq="113" ref="0" bb="32" group="27" />
+                          </Parameter>
+                          <Parameter id="HM1jMzqbqEuDJPHxV-Zu4A" name="Lymph flow rate" description="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="oycYaJK_AUabQcZsxoWAsA" isDefault="1" displayUnit="l/min">
+                            <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                            <Info min="0" flag="122" seq="113" ref="0" bb="32" group="58" />
+                          </Parameter>
+                          <Parameter id="qFUlOunZ2k2hziOo_9mDUQ" name="Volume (endothelium)" description="Volume of  vascular endothelium" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="1KjGMl-QlkO9LxcVJD_sZg" isDefault="1" displayUnit="l">
+                            <Info min="0" flag="62" seq="113" ref="0" bb="32" group="127" />
+                          </Parameter>
+                          <Parameter id="0fsZqgkvyU-9l6kVTNZrqg" name="Blood flow rate" description="Organ blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="-59WJ32EKk6Yd8JvyG1b8Q" isDefault="1" displayUnit="l/min">
+                            <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
+                            <Info min="0" flag="122" seq="302" ref="0" bb="32" group="5" />
+                          </Parameter>
+                          <Parameter id="TfRJHzOUgkqiszuE6zWqbg" name="Fraction intracellular" description="Fraction of intracellular space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ZxHXV_JusU-NQSlrOekb3w" isDefault="1">
+                            <Info min="0" max="1" flag="62" seq="340" ref="0" bb="32" group="64" />
+                          </Parameter>
+                          <Parameter id="5jvrmklP5EehFdVHZGsJIg" name="Density (tissue)" description="Density of tissue" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
+                            <Info min="0" flag="38" seq="1" ref="0" bb="32" group="21" />
+                          </Parameter>
+                          <Parameter id="NWlfit7CF0qE1UO1VwjrQA" name="Fraction mucosa" description="Mucosal fraction of regional intestinal tissue mass" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.26">
+                            <Info min="0" max="1" flag="122" seq="1" ref="0" bb="32" group="40" />
+                          </Parameter>
+                          <Parameter id="VOfFLcpr0Ui7hb0M6cp8Qg" name="Fraction of regional blood flow rate" description="Regional blood flow fraction supplying the mucosal tissue of the segment" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.219">
+                            <Info min="0" flag="54" seq="1" ref="0" bb="32" group="39" />
+                          </Parameter>
+                          <Parameter id="TsYPvDoA0EiTJ8Pq3pD4Ow" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                            <Info min="0" max="1" flag="54" seq="1" ref="0" bb="32" group="94" />
+                          </Parameter>
+                          <Parameter id="5IgxqvQrHU6Ys1ZlqAEQrw" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.05">
+                            <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                            <Info min="0" max="1" flag="122" seq="113" ref="0" bb="32" group="114" />
+                          </Parameter>
+                          <Parameter id="z1Fz06H_aUe-mz-8E0vgjQ" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" icon="Parameter" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.53888888888889E-10" displayUnit="ml/min/N">
+                            <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                            <Info min="0" flag="122" seq="113" ref="0" bb="32" group="115" />
+                          </Parameter>
+                          <Parameter id="iAXzcchnuUm4OzkDk-zC3Q" name="Radius (large pores)" description="Large endothelial pores radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.5E-07" displayUnit="µm">
+                            <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                            <Info min="0" flag="122" seq="113" ref="0" bb="32" group="55" />
+                          </Parameter>
+                          <Parameter id="ecyMTUVNBUGLB69mN_kj_Q" name="Radius (small pores)" description="Small endothelial pores radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="4.5E-08" displayUnit="µm">
+                            <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                            <Info min="0" flag="122" seq="113" ref="0" bb="32" group="99" />
+                          </Parameter>
+                          <Parameter id="tbuKSvdT3kCplHL4xeB7bw" name="Fraction vascular" description="Fraction of vascular space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.13">
+                            <Info min="0" max="1" flag="62" seq="339" ref="0" bb="32" group="64" />
+                          </Parameter>
+                          <Parameter id="nIJPseH7c0Se1bb49lRbzA" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.06">
+                            <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
+                            <Info min="0" max="1" flag="122" seq="339" ref="0" bb="32" group="85" />
+                          </Parameter>
+                          <Parameter id="YbFxd8zc5USDgUxR1DWJMQ" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0487">
+                            <Info min="0" max="1" flag="122" seq="339" ref="0" bb="32" group="86" />
+                          </Parameter>
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+                            <Info min="0" max="1000" flag="122" seq="574" ref="0" bb="32" group="92" />
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+                              <Tag value="SmallIntestineSegment" />
+                              <Tag value="UpperIleum" />
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+                              <Parameter id="y05vA5JadU6QQJB2_8Obmw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="jUuicTjwYECqpkpEHOcv6w" isDefault="1" displayUnit="l">
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+                                  <Parameter id="4LyP2Zw4pUqysh5fRFpwgA" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_o63arufdk2PTQFsOiSkqg" isDefault="1">
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+                                  <Parameter id="pxyinJGfv0-QMy-1br40rg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="pDRD-WocckCSQtVxG1Keug" isDefault="1">
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+                                  </Parameter>
+                                  <Parameter id="DtY7fQgDuky7LdcohrvMww" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="YQERj92sg0eOeddA3tJEnw" isDefault="1" displayUnit="min">
+                                    <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
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+                          </Container>
+                          <Container id="r0WtY-vx3UWxfs1sK8Zxcg" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
+                            <Tags>
+                              <Tag value="Mucosa" />
+                              <Tag value="SmallIntestineSegment" />
+                              <Tag value="UpperIleum" />
+                            </Tags>
+                            <Children>
+                              <Parameter id="xnGZVPAFrEyVbbqJ8xBUrA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="jUuicTjwYECqpkpEHOcv6w" isDefault="1" displayUnit="l">
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+                                <Children>
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+                                  <Parameter id="09jH53-60EyuRvyrdFjlkg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_B4r1Pf9BEa0ce4IJUo7mA" isDefault="1">
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+                              <Tag value="SmallIntestineSegment" />
+                              <Tag value="UpperIleum" />
+                            </Tags>
+                            <Children>
+                              <Parameter id="ymaE8-XZSUqOb8r9QeYPRA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="jUuicTjwYECqpkpEHOcv6w" isDefault="1" displayUnit="l">
+                                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                              </Parameter>
+                              <Parameter id="96mJSkXS9kqqWRkMtAyTzw" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="FsvYOeKl5kaJQ1JZ4JcXpg" isDefault="1" displayUnit="l">
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+                              <Parameter id="ckCsNYUkYEejeXhy_AIklQ" name="pH" description="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="vNehtSpde0yreA4KgSiy2A" isDefault="1">
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+                              <Tag value="SmallIntestineSegment" />
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+                            </Tags>
+                            <Children>
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+                                <Tags>
+                                  <Tag value="IntestinalSecretionSource" />
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+                                    <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                                  </Parameter>
+                                  <Parameter id="Evt9ROmEKkCFyWpfDMgFKQ" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="YQERj92sg0eOeddA3tJEnw" isDefault="1" displayUnit="min">
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+                      <Container id="xtLIAXcQ50OeMgYxgd40zg" name="LowerIleum" description="Lower Ileum" icon="LowerIleum" mode="Logical" containerType="Compartment">
+                        <Children>
+                          <Parameter id="0Wn5XIQlgEykBUT9UEDpYg" name="Weight (tissue)" description="Weight of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="wccWBS9A2kuoeEsL1_z2ww" isDefault="1" displayUnit="kg">
+                            <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
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+                          <Parameter id="o5nkHX9ZS0aXXX8Xsv99aQ" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="E7p6wRzBH0yKt2_R4YFlLg" isDefault="1" displayUnit="l">
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+                            <Info min="0" flag="122" seq="24" ref="0" bb="32" group="65" />
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+                          <Parameter id="c0M0UbeAoU-91nb5XJhIXA" name="Volume (endothelium)" description="Volume of  vascular endothelium" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="lTeCO4jbI06szxB_phbe3A" isDefault="1" displayUnit="l">
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+                          <Parameter id="eoNvdc3e-UuOyq-oiEcjhg" name="Blood flow rate" description="Organ blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="-59WJ32EKk6Yd8JvyG1b8Q" isDefault="1" displayUnit="l/min">
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+                          <Parameter id="4dZbhEPJ80O1nQm8K6t2Qw" name="Fraction intracellular" description="Fraction of intracellular space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ZxHXV_JusU-NQSlrOekb3w" isDefault="1">
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+                            <Info min="0" max="1" flag="122" seq="1" ref="0" bb="32" group="40" />
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+                          <Parameter id="JkM25irjjkehy6qibRQ2rw" name="Fraction of regional blood flow rate" description="Regional blood flow fraction supplying the mucosal tissue of the segment" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.2345">
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+                            <Info min="0" max="1" flag="122" seq="345" ref="0" bb="32" group="85" />
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+                            <Info min="0" max="1" flag="122" seq="346" ref="0" bb="32" group="85" />
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+                            <Info min="0" max="1" flag="62" seq="347" ref="0" bb="32" group="64" />
+                          </Parameter>
+                          <Parameter id="RIkGxdNOEUKI2ecDt_h0RA" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.158">
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+                            <Info min="0" max="1" flag="122" seq="347" ref="0" bb="32" group="112" />
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+                          <Parameter id="xcE7ENoZ_Uinhy3ep4bFBg" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.8">
+                            <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
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+                          <Parameter id="w0dFs8p5SUa98hN1UVenCg" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0375">
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+                            <Info min="0" max="1" flag="122" seq="575" ref="0" bb="32" group="92" />
+                          </Parameter>
+                          <Parameter id="CYvVPAchTkKd3wBKZq17JA" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0483">
+                            <Info min="0" max="1" flag="122" seq="575" ref="0" bb="32" group="95" />
+                          </Parameter>
+                          <Parameter id="FysjBmbR4Uaf-8nYalFTEg" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0124">
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+                            <Info min="0" max="1" flag="122" seq="576" ref="0" bb="32" group="92" />
+                          </Parameter>
+                          <Parameter id="1AfWomUhqE-ydYTEoreWXg" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0182">
+                            <Info min="0" max="1" flag="122" seq="576" ref="0" bb="32" group="95" />
+                          </Parameter>
+                          <Parameter id="yH5vfNYAi0CvP0ORW6po3A" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.282">
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+                            <Info min="0" max="1" flag="122" seq="577" ref="0" bb="32" group="92" />
+                          </Parameter>
+                          <Parameter id="XbXD45EqjUufub1hyFIH-Q" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.15">
+                            <Info min="0" max="1" flag="122" seq="577" ref="0" bb="32" group="95" />
+                          </Parameter>
+                          <Parameter id="YL1v7b7FiUmLC3Al5UZvGw" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.456">
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+                            <Info min="0" max="1" flag="122" seq="578" ref="0" bb="32" group="92" />
+                          </Parameter>
+                          <Parameter id="8kZ8r5WccEmX7OwDZICpyA" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.78">
+                            <Info min="0" max="1" flag="122" seq="578" ref="0" bb="32" group="95" />
+                          </Parameter>
+                          <Parameter id="7mRPH36BS06DEtScLFuckA" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.41">
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+                            <Info min="0" max="1000" flag="122" seq="579" ref="0" bb="32" group="92" />
+                          </Parameter>
+                          <Parameter id="qRH5ZUQEnkS5loFmy_cNCg" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0035">
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+                          </Parameter>
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+                              <Tag value="LowerIleum" />
+                              <Tag value="Mucosa" />
+                              <Tag value="SmallIntestineSegment" />
+                            </Tags>
+                            <Children>
+                              <Parameter id="YLdGyJr0q0u5MMp8P8c-kA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="jUuicTjwYECqpkpEHOcv6w" isDefault="1" displayUnit="l">
+                                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                              </Parameter>
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+                                <Info min="0" flag="62" seq="115" ref="0" bb="2" group="126" />
+                              </Parameter>
+                              <Container id="5RP_WGULcEW_yGp8qQT6DA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
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+                                    <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                                  </Parameter>
+                                  <Parameter id="RBZTi2Txb0mczu_mZM1Abw" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="YQERj92sg0eOeddA3tJEnw" isDefault="1" displayUnit="min">
+                                    <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
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+                              </Container>
+                            </Children>
+                          </Container>
+                          <Container id="UfLnRhyqGECHvI26DqDXOQ" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
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+                              <Tag value="LowerIleum" />
+                              <Tag value="Mucosa" />
+                              <Tag value="SmallIntestineSegment" />
+                            </Tags>
+                            <Children>
+                              <Parameter id="UaDciNpDG0iG-2BW3_vi2g" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="jUuicTjwYECqpkpEHOcv6w" isDefault="1" displayUnit="l">
+                                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                              </Parameter>
+                              <Parameter id="MkqNgS8BEUyCt7VR2JedAA" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="V2_FdO3puUGekuCdqn4lGg" isDefault="1" displayUnit="l">
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+                                <Info min="0" flag="62" seq="115" ref="0" bb="2" group="121" />
+                              </Parameter>
+                              <Container id="WEJQKbHU_Em0v81V_l7e9g" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
+                                <Children>
+                                  <Parameter id="HeBQtxLff06p5vlD0I3QOw" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_o63arufdk2PTQFsOiSkqg" isDefault="1">
+                                    <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
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+                                  <Parameter id="iquSj7uzs0WVdS2l6xsEDA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_B4r1Pf9BEa0ce4IJUo7mA" isDefault="1">
+                                    <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                                  </Parameter>
+                                  <Parameter id="wcfcGxmpaUKPfi8h2d-0-A" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="YQERj92sg0eOeddA3tJEnw" isDefault="1" displayUnit="min">
+                                    <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
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+                          </Container>
+                          <Container id="7b85cR4vJ0aGJEWuwq4eQA" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
+                            <Tags>
+                              <Tag value="LowerIleum" />
+                              <Tag value="Mucosa" />
+                              <Tag value="SmallIntestineSegment" />
+                            </Tags>
+                            <Children>
+                              <Parameter id="oz7V1M7HbUucQanaWUm5Qg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="jUuicTjwYECqpkpEHOcv6w" isDefault="1" displayUnit="l">
+                                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
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+                                <Info min="0" flag="62" seq="115" ref="0" bb="2" group="124" />
+                              </Parameter>
+                              <Parameter id="DXiZeqHLNUGPWnMffvvtcg" name="pH" description="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="vNehtSpde0yreA4KgSiy2A" isDefault="1">
+                                <Tags>
+                                  <Tag value="LowerIleum" />
+                                  <Tag value="Mucosa" />
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+                                </Tags>
+                                <Info min="0" max="14" flag="122" seq="347" ref="0" bb="32" group="84" />
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+                              <Container id="7CbFQjKrDU6yQv-4lyHz_Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
+                                <Children>
+                                  <Parameter id="ZwahcppGC0yXbGS5Ahh6fQ" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_o63arufdk2PTQFsOiSkqg" isDefault="1">
+                                    <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                                  </Parameter>
+                                  <Parameter id="zAw1hPXNNkyMaNpKeRL3Iw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="5i45Lz7BDkqZhyxL7WMcNQ" isDefault="1">
+                                    <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
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+                                  <Parameter id="DoQQlbgVcUe46fNa8HtDtw" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="YQERj92sg0eOeddA3tJEnw" isDefault="1" displayUnit="min">
+                                    <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
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+                            </Children>
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+                              <Tag value="LowerIleum" />
+                              <Tag value="Mucosa" />
+                              <Tag value="SmallIntestineSegment" />
+                            </Tags>
+                            <Children>
+                              <Parameter id="JCwiF6ltFEu5EJrFdROxSA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="-ijMbq55KEWxwtKNegWm3g" isDefault="1" displayUnit="l">
+                                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
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+                              <Parameter id="cEPgEa4nRUCvKx_CminmZw" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="nGzrbq1s0U6FgEbhM3oFgQ" isDefault="1" displayUnit="l">
+                                <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                                <Info min="0" flag="62" seq="115" ref="0" bb="2" group="125" />
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+                              <Parameter id="a-SgKeSAfUuAb-HYx0z-sQ" name="pH" description="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.3">
+                                <Tags>
+                                  <Tag value="IntestinalSecretionSource" />
+                                  <Tag value="LowerIleum" />
+                                  <Tag value="Mucosa" />
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+                                <Info min="0" max="14" flag="122" seq="347" ref="0" bb="32" group="83" />
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+                                  <Parameter id="csLdgpXM4U-33FmKHqTYRA" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_o63arufdk2PTQFsOiSkqg" isDefault="1">
+                                    <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
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+                                    <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
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+                                  <Parameter id="Sl-MwFxGNUGR0qtz4UYWww" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="YQERj92sg0eOeddA3tJEnw" isDefault="1" displayUnit="min">
+                                    <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
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+                </Children>
+              </Container>
+              <Container id="_GWrA2UJhUioaxod1293LA" name="LargeIntestine" description="LargeIntestine" icon="LargeIntestine" mode="Logical" containerType="Organ">
+                <Tags>
+                  <Tag value="Portal Vein Supplying Organ" />
+                  <Tag value="TissueOrgan" />
+                </Tags>
+                <Children>
+                  <Parameter id="5JvnzQjUeEKv5TSjrX1ytw" name="Large intestinal transit time factor" description="Large intestinal transit time factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="80r9IeahNEen6xHrwAYvzg" isDefault="1">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="38" seq="1" ref="0" bb="32" group="46" />
+                  </Parameter>
+                  <Parameter id="10c-obzVmUWWcIdKOcSOCg" name="Volume (mucosa)" description="Volume of mucosa" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="QGgMbhSCpEO21EHBF2cuSw" isDefault="1" displayUnit="l">
+                    <Tags>
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+                      <Tag value="TissueOrgan" />
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+                    <Info min="0" flag="62" seq="1" ref="0" bb="32" group="129" />
+                  </Parameter>
+                  <Parameter id="QPaWh_W7C0mndISCH4CMiQ" name="Weight (tissue)" description="Weight of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="wccWBS9A2kuoeEsL1_z2ww" isDefault="1" displayUnit="kg">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
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+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
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+                  <Parameter id="z0h3VVtKAkWzzXDinrEOnQ" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="22iEX7_fxUShQLhymMklYw" isDefault="1" displayUnit="l/min">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
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+                    <Info min="0" flag="62" seq="16" ref="0" bb="32" group="27" />
+                  </Parameter>
+                  <Parameter id="NYdMQJTm5kSeQhm-zJxx_A" name="Fluid recirculation flow rate (incl. mucosa)" description="Fluid recirculation flow rate between plasma and interstitial space (incl. mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="_1qGrWaZQ0-mf9ujtwqKng" isDefault="1" displayUnit="l/min">
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+                    <Info min="0" flag="122" seq="16" ref="0" bb="32" group="58" />
+                  </Parameter>
+                  <Parameter id="EnNtuDWqvkqk2t2EFcXmgw" name="Volume (endothelium)" description="Volume of  vascular endothelium" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="3sl69TJkjkSKfVadIMNK8Q" isDefault="1" displayUnit="l">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="62" seq="16" ref="0" bb="32" group="127" />
+                  </Parameter>
+                  <Parameter id="g3Q67kCwSECzgdsx3p2TEg" name="Fraction intracellular" description="Fraction of intracellular space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ZxHXV_JusU-NQSlrOekb3w" isDefault="1">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="62" seq="49" ref="0" bb="32" group="64" />
+                  </Parameter>
+                  <Parameter id="i4aoIS2cv0edE8Y_482DSg" name="Blood flow rate" description="Organ blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="kOPtX3xlRUyjlOOtEoP9Yg" isDefault="1" displayUnit="l/min">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="48" source="Other" description="Absolute value = specific value (i.e. value normalized to the volume of the organ) multiplied by the organ volume" />
+                    <Info min="0" flag="62" seq="122" ref="0" bb="32" group="5" />
+                  </Parameter>
+                  <Parameter id="yTBprcVtNka_woQ52fwc_A" name="Density (tissue)" description="Density of tissue" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="38" seq="1" ref="0" bb="32" group="21" />
+                  </Parameter>
+                  <Parameter id="1rIBAt8lvkG-M_xw3Ub8jA" name="Fluid recirculation flow proportionality factor" description="proportionality factor linking fluid recirculation flow to lymph flow via small pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.179">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="27" />
+                  </Parameter>
+                  <Parameter id="dXfYNlnnQkmjAV9DheSSjg" name="Lymph flow proportionality factor" description="Proportionality factor linking lymph flow to plasma flow" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0144">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="58" />
+                  </Parameter>
+                  <Parameter id="GK-zhJv6v0yuluTw2qbA4w" name="Organ volume mouse" description="Organ volume mouse" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.000627" displayUnit="l">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="65" />
+                  </Parameter>
+                  <Parameter id="Xi9V46nOak6gXAgy4HjFXQ" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.75">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0.75" max="0.75" flag="54" seq="1" ref="0" bb="32" group="2" />
+                  </Parameter>
+                  <Parameter id="HIP5JUBDhkCwDSyF19yYAA" name="Large intestinal transit time factor intercept" description="Large intestinal transit time factor intercept" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="47.6">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info flag="52" seq="1" ref="0" bb="32" group="46" />
+                  </Parameter>
+                  <Parameter id="sQfHroYGVkGgKQmMzlxvGw" name="Large intestinal transit time factor slope" description="Large intestinal transit time factor slope" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.938" displayUnit="1/min">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info flag="52" seq="1" ref="0" bb="32" group="46" />
+                  </Parameter>
+                  <Parameter id="MsqM8oxt7UCpwFDUZLoc6w" name="Mucosa blood flow fraction" description="Blood fraction which goes to mucosa" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.75">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="39" />
+                  </Parameter>
+                  <Parameter id="sS2bB9RnDUqR_Lngjc-Jqw" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="54" seq="1" ref="0" bb="32" group="94" />
+                  </Parameter>
+                  <Parameter id="UdP_euUGuUCG1D68cUPf5w" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.05">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" max="1" flag="122" seq="16" ref="0" bb="32" group="114" />
+                  </Parameter>
+                  <Parameter id="rkXAur6bY0uERt1r7C9uyw" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" icon="Parameter" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.86944444444444E-10" displayUnit="ml/min/N">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="16" ref="0" bb="32" group="115" />
+                  </Parameter>
+                  <Parameter id="TUwIHH2qukqL55Ctxm2iYA" name="Radius (large pores)" description="Large endothelial pores radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.5E-07" displayUnit="µm">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="16" ref="0" bb="32" group="55" />
+                  </Parameter>
+                  <Parameter id="CPMKTnPfEk2-OL-me6opGA" name="Radius (small pores)" description="Small endothelial pores radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="4.5E-08" displayUnit="µm">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="16" ref="0" bb="32" group="99" />
+                  </Parameter>
+                  <Parameter id="8Klq1Lt-j0Wo0eVCNfU_hA" name="Fraction vascular" description="Fraction of vascular space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.024">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="19" source="Publication" description="Kawai R, Lemaire M, Steimer JL, Bruelisauer A, Niederberger W, Rowland M. Physiologically based pharmacokinetic study on a cyclosporin derivative, SDZ IMM 125. J Pharmacokinet Biopharm. 1994 Oct;22(5):327-65." />
+                    <Info min="0" max="1" flag="62" seq="48" ref="0" bb="32" group="64" />
+                  </Parameter>
+                  <Parameter id="w1mz-t7mQ0iwyYbb4Q8foQ" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.062">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
+                    <Info min="0" max="1" flag="122" seq="48" ref="0" bb="32" group="85" />
+                  </Parameter>
+                  <Parameter id="SuvR4tku4UqipB3ELwQa0Q" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0487">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="48" ref="0" bb="32" group="86" />
+                  </Parameter>
+                  <Parameter id="DuSg74Ykg0iuQKnwqCuh-Q" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0163">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="49" ref="0" bb="32" group="86" />
+                  </Parameter>
+                  <Parameter id="F1eOjtiGvE6re2e92hXkIA" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.133">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
+                    <Info min="0" max="1" flag="122" seq="49" ref="0" bb="32" group="85" />
+                  </Parameter>
+                  <Parameter id="KR3UPhBRgUuhig293ms1cw" name="Fraction interstitial" description="Fraction of interstitial space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.094">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="19" source="Publication" description="Kawai R, Lemaire M, Steimer JL, Bruelisauer A, Niederberger W, Rowland M. Physiologically based pharmacokinetic study on a cyclosporin derivative, SDZ IMM 125. J Pharmacokinet Biopharm. 1994 Oct;22(5):327-65." />
+                    <Info min="0" max="1" flag="62" seq="50" ref="0" bb="32" group="64" />
+                  </Parameter>
+                  <Parameter id="NMwNTxvrek26L-wjekO7-A" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.158">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="22" source="Publication" description="Rodgers T, Rowland M. Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J Pharm Sci. 2006 Jun;95(6):1238-57 https://doi.org/10.1002/jps.20502" />
+                    <Info min="0" max="1" flag="122" seq="50" ref="0" bb="32" group="111" />
+                  </Parameter>
+                  <Parameter id="PXaYmJN5tEmRzNOH_vb1IQ" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="24" source="Publication" description="POULIN P, THEIL F. Prediction of Pharmacokinetics Prior to In Vivo Studies. 1. Mechanism-Based Prediction of Volume of Distribution. JOURNAL OF PHARMACEUTICAL SCIENCES, VOL. 91, NO. 1, JANUARY 2002" />
+                    <Info min="0" max="1" flag="122" seq="50" ref="0" bb="32" group="112" />
+                  </Parameter>
+                  <Parameter id="Km5YNqVMAkuh1HCnIaf8FA" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.141">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="22" source="Publication" description="Rodgers T, Rowland M. Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J Pharm Sci. 2006 Jun;95(6):1238-57 https://doi.org/10.1002/jps.20502" />
+                    <Info min="0" max="1" flag="122" seq="50" ref="0" bb="32" group="113" />
+                  </Parameter>
+                  <Parameter id="-yLcAWb1cUevY26GWAWLvw" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.792">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
+                    <Info min="0" max="1" flag="122" seq="50" ref="0" bb="32" group="85" />
+                  </Parameter>
+                  <Parameter id="pkAUYDjM4Uq3nuA8f8k6iQ" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.718">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="50" ref="0" bb="32" group="86" />
+                  </Parameter>
+                  <Parameter id="y-w-LV1pA0m-JLsWL5bwIQ" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0375">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="22" source="Publication" description="Rodgers T, Rowland M. Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J Pharm Sci. 2006 Jun;95(6):1238-57 https://doi.org/10.1002/jps.20502" />
+                    <Info min="0" max="1" flag="122" seq="80" ref="0" bb="32" group="92" />
+                  </Parameter>
+                  <Parameter id="89jizC4xeEGXCcRx23UZPA" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0483">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="80" ref="0" bb="32" group="95" />
+                  </Parameter>
+                  <Parameter id="L6_tzBrDx0S94GpTNvTeXQ" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0124">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="22" source="Publication" description="Rodgers T, Rowland M. Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J Pharm Sci. 2006 Jun;95(6):1238-57 https://doi.org/10.1002/jps.20502" />
+                    <Info min="0" max="1" flag="122" seq="81" ref="0" bb="32" group="92" />
+                  </Parameter>
+                  <Parameter id="BKKWfGoYP02qszCKSZJ1VA" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0182">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="81" ref="0" bb="32" group="95" />
+                  </Parameter>
+                  <Parameter id="HQYMYzYheEytsldeSxGydA" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.282">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="21" source="Publication" description="Rodgers T, Leahy D, Rowland M. Physiologically based pharmacokinetic modeling 1: predicting the tissue distribution of moderate-to-strong bases. J Pharm Sci. 2005 Jun;94(6):1259-76. https://doi.org/10.1002/jps.20322" />
+                    <Info min="0" max="1" flag="122" seq="82" ref="0" bb="32" group="92" />
+                  </Parameter>
+                  <Parameter id="hvLol4oXmky7Wo8q9nauAw" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.15">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="82" ref="0" bb="32" group="95" />
+                  </Parameter>
+                  <Parameter id="EPnY7jWSSU2FpmcalYuI3Q" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.456">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="22" source="Publication" description="Rodgers T, Rowland M. Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J Pharm Sci. 2006 Jun;95(6):1238-57 https://doi.org/10.1002/jps.20502" />
+                    <Info min="0" max="1" flag="122" seq="83" ref="0" bb="32" group="92" />
+                  </Parameter>
+                  <Parameter id="47UNDkkNTUCb1S1touJ55Q" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.78">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="83" ref="0" bb="32" group="95" />
+                  </Parameter>
+                  <Parameter id="sJUEQLHvU0WUYdpPgEUohQ" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.41">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="21" source="Publication" description="Rodgers T, Leahy D, Rowland M. Physiologically based pharmacokinetic modeling 1: predicting the tissue distribution of moderate-to-strong bases. J Pharm Sci. 2005 Jun;94(6):1259-76. https://doi.org/10.1002/jps.20322" />
+                    <Info min="0" max="1000" flag="122" seq="84" ref="0" bb="32" group="92" />
+                  </Parameter>
+                  <Parameter id="G1z_rqW6MUu9lkHJC8Zb0A" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0035">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="84" ref="0" bb="32" group="95" />
+                  </Parameter>
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+                      <Parameter id="PRU7DAmHZUysfN8ihaS_xA" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.41217159744" displayUnit="l">
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+                        <Info min="0" flag="50" seq="1" ref="0" bb="32" group="5" />
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+                      <Tag value="Portal Vein Supplying Organ" />
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+                      <Parameter id="kgoWYjwVbUuHP5D2wYVe0w" name="pH" description="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="vNehtSpde0yreA4KgSiy2A" isDefault="1">
+                        <Tags>
+                          <Tag value="LargeIntestine" />
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+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
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+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
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+                            <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
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+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
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+                          <Parameter id="XDEKiFileEGZDtZb4TeTNg" name="Weight (tissue)" description="Weight of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="wccWBS9A2kuoeEsL1_z2ww" isDefault="1" displayUnit="kg">
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+                          <Parameter id="DvEh7ucCgU2_Ent1jfgg5A" name="Fraction intracellular" description="Fraction of intracellular space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ZxHXV_JusU-NQSlrOekb3w" isDefault="1">
+                            <Info min="0" max="1" flag="62" seq="349" ref="0" bb="32" group="64" />
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+                            <Info min="0" max="1" flag="122" seq="1" ref="0" bb="32" group="40" />
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+                          <Parameter id="PVbJcHC3hke09Mtg7XBSjA" name="Fraction of regional blood flow rate" description="Regional blood flow fraction supplying the mucosal tissue of the segment" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.084706">
+                            <Info min="0" flag="54" seq="1" ref="0" bb="32" group="39" />
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+                          <Parameter id="KSa6T5k7JE6UjfV2ba-TSQ" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                            <Info min="0" max="1" flag="54" seq="1" ref="0" bb="32" group="94" />
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+                          <Parameter id="LDmxG1VZOUOFa_HWnWgpSg" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.05">
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+                            <Info min="0" max="1" flag="122" seq="116" ref="0" bb="32" group="114" />
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+                          <Parameter id="TZ2O8e6LeUyzTwn5a2tXow" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" icon="Parameter" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.86944444444444E-10" displayUnit="ml/min/N">
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+                          <Parameter id="uwgqxaf26keZA-TIwy7gWQ" name="Fraction vascular" description="Fraction of vascular space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.13">
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+                          <Parameter id="mj6zSn-3E0mxHPFzTMvM-g" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.06">
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+                            <Info min="0" max="1" flag="122" seq="348" ref="0" bb="32" group="85" />
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+                            <Info min="0" max="1" flag="122" seq="348" ref="0" bb="32" group="86" />
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+                            <Info min="0" max="1" flag="122" seq="349" ref="0" bb="32" group="85" />
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+                          <Parameter id="Xrr7utMEMkiU2ckXeuMP_g" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.158">
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+                          <Parameter id="gD7ndIwzMEGLGAyNnGvIKw" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0375">
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+                          <Parameter id="0hYHiM3O1kWN-0PELKqBvQ" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.282">
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+                              <Tag value="LargeIntestineSegment" />
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+                              <Tag value="LargeIntestineSegment" />
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+                                <Tags>
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+                                    <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
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+                                  <Parameter id="Jb8meaF_nUuqX8mApRoQxg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="XCEQm4K3KU6kn12G_tWpCQ" isDefault="1">
+                                    <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
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+                                    <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
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+                              <Tag value="IntestinalSecretionSource" />
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+                                <Tags>
+                                  <Tag value="Caecum" />
+                                  <Tag value="IntestinalSecretionSource" />
+                                  <Tag value="LargeIntestineSegment" />
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+                              <Container id="9Sdxw1CeLUWUHjgxlL4tCQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
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+                                  <Parameter id="mxQ5uZ6loUCFISwOOieSyg" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="YQERj92sg0eOeddA3tJEnw" isDefault="1" displayUnit="min">
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+                          <Container id="MMuLHyyA_kuWrtnNHK3-SA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule" />
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+                          <Parameter id="VQQVeazZmkycC7JdILN6Pg" name="Weight (tissue)" description="Weight of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="wccWBS9A2kuoeEsL1_z2ww" isDefault="1" displayUnit="kg">
+                            <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
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+                          <Parameter id="IGfOsjwmhESwexYMo004rg" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="W7x7hK_gvEOLInc2cycSrw" isDefault="1" displayUnit="l">
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+                            <Info min="0" flag="122" seq="26" ref="0" bb="32" group="65" />
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+                          <Parameter id="pbTkJzeNLk2U859_-HALVg" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="043DNcStI0-iJ7SmugQrkQ" isDefault="1" displayUnit="l/min">
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+                          <Parameter id="_LpmADsxJUOIRcdrCXuk8g" name="Lymph flow rate" description="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="oycYaJK_AUabQcZsxoWAsA" isDefault="1" displayUnit="l/min">
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+                          <Parameter id="Qr9EpXKJUUaqslgGn7jsug" name="Volume (endothelium)" description="Volume of  vascular endothelium" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="QbqDyXgU-ECYnuwTK59E3w" isDefault="1" displayUnit="l">
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+                          <Parameter id="ukS7whQYLUqtX_vnAMMEfg" name="Blood flow rate" description="Organ blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="-59WJ32EKk6Yd8JvyG1b8Q" isDefault="1" displayUnit="l/min">
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+                            <Info min="0" flag="122" seq="306" ref="0" bb="32" group="5" />
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+                          <Parameter id="T-dmwSMMFUyv0rbk27pzKw" name="Fraction intracellular" description="Fraction of intracellular space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ZxHXV_JusU-NQSlrOekb3w" isDefault="1">
+                            <Info min="0" max="1" flag="62" seq="352" ref="0" bb="32" group="64" />
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+                          <Parameter id="7lZyhW3SWkKBx9-OzCqqoA" name="Density (tissue)" description="Density of tissue" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
+                            <Info min="0" flag="38" seq="1" ref="0" bb="32" group="21" />
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+                          <Parameter id="Pev8LRp4pEm_e371ZeWSwg" name="Fraction mucosa" description="Mucosal fraction of regional intestinal tissue mass" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.19">
+                            <Info min="0" max="1" flag="122" seq="1" ref="0" bb="32" group="40" />
+                          </Parameter>
+                          <Parameter id="wkofHsWF9EOD5bu1-c3pmw" name="Fraction of regional blood flow rate" description="Regional blood flow fraction supplying the mucosal tissue of the segment" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.15529">
+                            <Info min="0" flag="54" seq="1" ref="0" bb="32" group="39" />
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+                            <Info min="0" max="1" flag="54" seq="1" ref="0" bb="32" group="94" />
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+                          <Parameter id="z5dJPfpyTkOlQ6ntmH8p0g" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.05">
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+                          <Parameter id="eT1Hbqn1bU2kXVr9S6SxKQ" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" icon="Parameter" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.86944444444444E-10" displayUnit="ml/min/N">
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+                            <Info min="0" flag="122" seq="117" ref="0" bb="32" group="99" />
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+                          <Parameter id="IZzpr0BsV0SSRa1Dvp9Gmw" name="Fraction vascular" description="Fraction of vascular space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.13">
+                            <Info min="0" max="1" flag="62" seq="351" ref="0" bb="32" group="64" />
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+                          <Parameter id="H5kNVh0Df0upES7k1p4jvg" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.06">
+                            <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
+                            <Info min="0" max="1" flag="122" seq="351" ref="0" bb="32" group="85" />
+                          </Parameter>
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+                            <Info min="0" max="1" flag="122" seq="351" ref="0" bb="32" group="86" />
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+                            <Info min="0" max="1" flag="122" seq="352" ref="0" bb="32" group="85" />
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+                          <Parameter id="hOCKssQMYEC7BSiDVWX8ng" name="Fraction interstitial" description="Fraction of interstitial space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.73">
+                            <Info min="0" max="1" flag="62" seq="353" ref="0" bb="32" group="64" />
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+                          <Parameter id="-ADuyqr8h0-WF7BQwHCYGQ" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.158">
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+                          <Parameter id="ku0hlSJjH0iznZGog4lFtw" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.8">
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+                          <Parameter id="8T1MYIeIW02cXLTXOQR-aQ" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0375">
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+                          <Parameter id="buN0wqnigk6KzOvimsWLGg" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0124">
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+                            <Info min="0" max="1" flag="122" seq="586" ref="0" bb="32" group="92" />
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+                          <Parameter id="FN0leFYde0yi5wwIuEYyfw" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0182">
+                            <Info min="0" max="1" flag="122" seq="586" ref="0" bb="32" group="95" />
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+                          <Parameter id="8uDAGOYc70abfEiKG-6U5g" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.282">
+                            <ValueOrigin id="21" source="Publication" description="Rodgers T, Leahy D, Rowland M. Physiologically based pharmacokinetic modeling 1: predicting the tissue distribution of moderate-to-strong bases. J Pharm Sci. 2005 Jun;94(6):1259-76. https://doi.org/10.1002/jps.20322" />
+                            <Info min="0" max="1" flag="122" seq="587" ref="0" bb="32" group="92" />
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+                          <Parameter id="NnZubF1fK0e5iLJa1ZHyHw" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.15">
+                            <Info min="0" max="1" flag="122" seq="587" ref="0" bb="32" group="95" />
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+                          <Parameter id="-FKkRKvl00WveIfp-_La6g" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.456">
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+                            <Info min="0" max="1" flag="122" seq="588" ref="0" bb="32" group="92" />
+                          </Parameter>
+                          <Parameter id="VUugm8UkyUuJcF_bdPQzaw" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.78">
+                            <Info min="0" max="1" flag="122" seq="588" ref="0" bb="32" group="95" />
+                          </Parameter>
+                          <Parameter id="kSdIIG7E3kOgKE6_RSnrGw" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.41">
+                            <ValueOrigin id="21" source="Publication" description="Rodgers T, Leahy D, Rowland M. Physiologically based pharmacokinetic modeling 1: predicting the tissue distribution of moderate-to-strong bases. J Pharm Sci. 2005 Jun;94(6):1259-76. https://doi.org/10.1002/jps.20322" />
+                            <Info min="0" max="1000" flag="122" seq="589" ref="0" bb="32" group="92" />
+                          </Parameter>
+                          <Parameter id="x9xBPOwQcUWFJgIfTaC0YQ" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0035">
+                            <Info min="0" max="1" flag="122" seq="589" ref="0" bb="32" group="95" />
+                          </Parameter>
+                          <Container id="nddA3OCFX0GdKSVDib1zbQ" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
+                            <Tags>
+                              <Tag value="ColonAscendens" />
+                              <Tag value="LargeIntestineSegment" />
+                              <Tag value="Mucosa" />
+                            </Tags>
+                            <Children>
+                              <Parameter id="6LAgqQ7tI0OlIPjtop4LBA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="jUuicTjwYECqpkpEHOcv6w" isDefault="1" displayUnit="l">
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+                              <Tag value="LargeIntestineSegment" />
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+                              <Tag value="LargeIntestineSegment" />
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+                            </Tags>
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+                              <Tag value="IntestinalSecretionSource" />
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+                                  <Tag value="ColonAscendens" />
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+                          <Parameter id="igpUzJvWZUuv8M3I0bHamQ" name="Weight (tissue)" description="Weight of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="wccWBS9A2kuoeEsL1_z2ww" isDefault="1" displayUnit="kg">
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+                          <Parameter id="ejf4AzCZnUqJZxDyMkLDaQ" name="Fraction intracellular" description="Fraction of intracellular space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ZxHXV_JusU-NQSlrOekb3w" isDefault="1">
+                            <Info min="0" max="1" flag="62" seq="355" ref="0" bb="32" group="64" />
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+                            <Info min="0" max="1" flag="122" seq="1" ref="0" bb="32" group="40" />
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+                          <Parameter id="Ekcq4jlabkCxuz5fDDsXDA" name="Fraction vascular" description="Fraction of vascular space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.12">
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+                          <Parameter id="TUXHpUSdRUKcy4Ojy0ggtg" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.06">
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+                          <Parameter id="7l9goz-xz02eYpuo3qai_Q" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.158">
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+                          <Parameter id="91t-21ugN0uGWMXGOq1X5w" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.8">
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+                          <Parameter id="1UJ-xFCpnkub8wRYOZ1g_A" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0375">
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+                          <Parameter id="Ha3OKe1otkmJjC9lz9BU-w" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.282">
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+                              <Tag value="LargeIntestineSegment" />
+                              <Tag value="Mucosa" />
+                            </Tags>
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+                              <Parameter id="IUCOfIc-ykC9_uxbnAyLjA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="jUuicTjwYECqpkpEHOcv6w" isDefault="1" displayUnit="l">
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+                              <Parameter id="an55jd71T0SWCXX8YlJ2rg" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="2ErPZJcYvUyL3QogRRKmZg" isDefault="1" displayUnit="l">
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+                              <Container id="V-FM9mu5I0Wyy7GBvEzrtg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
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+                                  <Parameter id="4YC26FGw0E6gie0AnzV7dQ" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_o63arufdk2PTQFsOiSkqg" isDefault="1">
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+                                    <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
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+                          </Container>
+                          <Container id="9tf7XE_EBkqMwcotfbazmQ" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
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+                              <Tag value="LargeIntestineSegment" />
+                              <Tag value="Mucosa" />
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+                                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
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+                              <Parameter id="PBQgGWS6X0u5R69Dd6g0Uw" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="V2_FdO3puUGekuCdqn4lGg" isDefault="1" displayUnit="l">
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+                                <Info min="0" flag="62" seq="118" ref="0" bb="2" group="121" />
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+                                  <Parameter id="DbJ9IQK9S0Gizh2C7lArXA" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_o63arufdk2PTQFsOiSkqg" isDefault="1">
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+                                    <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
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+                                  <Parameter id="dJry-SXdW02a4bOhCNQ5wg" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="YQERj92sg0eOeddA3tJEnw" isDefault="1" displayUnit="min">
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+                              <Tag value="LargeIntestineSegment" />
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+                              <Tag value="IntestinalSecretionSource" />
+                              <Tag value="LargeIntestineSegment" />
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+                          <Parameter id="yTSEF9Lqi0Wba0YV3NTJVQ" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="043DNcStI0-iJ7SmugQrkQ" isDefault="1" displayUnit="l/min">
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+                          <Parameter id="CYIuG6FVVk63sApexGhypg" name="Lymph flow rate" description="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="oycYaJK_AUabQcZsxoWAsA" isDefault="1" displayUnit="l/min">
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+                          <Parameter id="QN9jqdG6SUirC4nM_FXljw" name="Volume (endothelium)" description="Volume of  vascular endothelium" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="7lppG989z0-8x6sUXOLNaQ" isDefault="1" displayUnit="l">
+                            <Info min="0" flag="62" seq="119" ref="0" bb="32" group="127" />
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+                          <Parameter id="jg_2KszZPEaL0Ubr_pIUGg" name="Blood flow rate" description="Organ blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="-59WJ32EKk6Yd8JvyG1b8Q" isDefault="1" displayUnit="l/min">
+                            <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
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+                          <Parameter id="jDZ721rKc0CaxlXjF2XAsw" name="Fraction intracellular" description="Fraction of intracellular space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ZxHXV_JusU-NQSlrOekb3w" isDefault="1">
+                            <Info min="0" max="1" flag="62" seq="358" ref="0" bb="32" group="64" />
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+                            <Info min="0" flag="38" seq="1" ref="0" bb="32" group="21" />
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+                            <Info min="0" max="1" flag="122" seq="1" ref="0" bb="32" group="40" />
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+                          <Parameter id="XgkBig90t0WfjOUogYC4nA" name="Fraction of regional blood flow rate" description="Regional blood flow fraction supplying the mucosal tissue of the segment" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.24">
+                            <Info min="0" flag="54" seq="1" ref="0" bb="32" group="39" />
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+                          <Parameter id="BjN_t4cO70yDlOmcJMpLmA" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                            <Info min="0" max="1" flag="54" seq="1" ref="0" bb="32" group="94" />
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+                          <Parameter id="5q_RNyYnPUSh_GjJvHBJhg" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.05">
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+                            <Info min="0" max="1" flag="122" seq="119" ref="0" bb="32" group="114" />
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+                          <Parameter id="eK8ViYOAgkSfbeNZBEszaw" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" icon="Parameter" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.86944444444444E-10" displayUnit="ml/min/N">
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+                            <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
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+                          <Parameter id="dAsudu2UAEW-X-1HsR33DA" name="Radius (small pores)" description="Small endothelial pores radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="4.5E-08" displayUnit="µm">
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+                            <Info min="0" flag="122" seq="119" ref="0" bb="32" group="99" />
+                          </Parameter>
+                          <Parameter id="eiKKVgZAQECPKe_ZiIwNGA" name="Fraction vascular" description="Fraction of vascular space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.12">
+                            <Info min="0" max="1" flag="62" seq="357" ref="0" bb="32" group="64" />
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+                          <Parameter id="07Qh839F1UGXo1U7af6M7A" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.06">
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+                            <Info min="0" max="1" flag="122" seq="357" ref="0" bb="32" group="85" />
+                          </Parameter>
+                          <Parameter id="CcQAuLJVi0KHjK2qGl0buw" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0487">
+                            <Info min="0" max="1" flag="122" seq="357" ref="0" bb="32" group="86" />
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+                          <Parameter id="Bb2oN8PP1U2SSZC0t23Scw" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0163">
+                            <Info min="0" max="1" flag="122" seq="358" ref="0" bb="32" group="86" />
+                          </Parameter>
+                          <Parameter id="WfZtiwxW10mJEm9rb6cJtg" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.08">
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+                            <Info min="0" max="1" flag="122" seq="358" ref="0" bb="32" group="85" />
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+                          <Parameter id="z3SgaeCKw0GLul7wRQo6zA" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.158">
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+                            <Info min="0" max="1000" flag="122" seq="599" ref="0" bb="32" group="92" />
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+                              <Tag value="LargeIntestineSegment" />
+                              <Tag value="Mucosa" />
+                            </Tags>
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+                              <Parameter id="Ht7awzAGnkO4wxY-4yxvCA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="jUuicTjwYECqpkpEHOcv6w" isDefault="1" displayUnit="l">
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+                                    <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
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+                                  <Parameter id="ELFPyC7vnEKC0xpwcxETmg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="pDRD-WocckCSQtVxG1Keug" isDefault="1">
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+                                  <Parameter id="5RuxJeuxpEGjryZ-h2UTqw" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="YQERj92sg0eOeddA3tJEnw" isDefault="1" displayUnit="min">
+                                    <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
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+                            </Children>
+                          </Container>
+                          <Container id="b1XobftQwUiN9-8v8K-ffA" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
+                            <Tags>
+                              <Tag value="ColonDescendens" />
+                              <Tag value="LargeIntestineSegment" />
+                              <Tag value="Mucosa" />
+                            </Tags>
+                            <Children>
+                              <Parameter id="vX1xgpp_ska83Do8UAXYfg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="jUuicTjwYECqpkpEHOcv6w" isDefault="1" displayUnit="l">
+                                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
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+                              <Parameter id="KT7gA2d6dkuaI_fpU6l-4Q" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="V2_FdO3puUGekuCdqn4lGg" isDefault="1" displayUnit="l">
+                                <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                                <Info min="0" flag="62" seq="119" ref="0" bb="2" group="121" />
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+                              <Container id="6K-O0wskS06NBSlg0bAOXQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
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+                                  <Parameter id="mtUx-IOqp0SwbWi9SN80zA" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_o63arufdk2PTQFsOiSkqg" isDefault="1">
+                                    <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
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+                                  <Parameter id="InnyGg-wSE6WMdL3u-f_OQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_B4r1Pf9BEa0ce4IJUo7mA" isDefault="1">
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+                              <Tag value="LargeIntestineSegment" />
+                              <Tag value="Mucosa" />
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+                                <Tags>
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+                                  <Tag value="ColonDescendens" />
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+                        <Children>
+                          <Parameter id="91DztiLuJkWRKIKQBxMUAg" name="Weight (tissue)" description="Weight of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="wccWBS9A2kuoeEsL1_z2ww" isDefault="1" displayUnit="kg">
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+                          <Parameter id="IejhNk4pRESy4I7l83rt3g" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.158">
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+                          <Parameter id="Yyct_G0ofUWh_OigOkm_mg" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0124">
+                            <ValueOrigin id="22" source="Publication" description="Rodgers T, Rowland M. Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J Pharm Sci. 2006 Jun;95(6):1238-57 https://doi.org/10.1002/jps.20502" />
+                            <Info min="0" max="1" flag="122" seq="601" ref="0" bb="32" group="92" />
+                          </Parameter>
+                          <Parameter id="_76HDvW3s0GeEZTgJXQpVw" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0182">
+                            <Info min="0" max="1" flag="122" seq="601" ref="0" bb="32" group="95" />
+                          </Parameter>
+                          <Parameter id="l11GGPUeiUGlQvmomayRWw" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.282">
+                            <ValueOrigin id="21" source="Publication" description="Rodgers T, Leahy D, Rowland M. Physiologically based pharmacokinetic modeling 1: predicting the tissue distribution of moderate-to-strong bases. J Pharm Sci. 2005 Jun;94(6):1259-76. https://doi.org/10.1002/jps.20322" />
+                            <Info min="0" max="1" flag="122" seq="602" ref="0" bb="32" group="92" />
+                          </Parameter>
+                          <Parameter id="hK22QPysZEqHmcxuT2NVEg" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.15">
+                            <Info min="0" max="1" flag="122" seq="602" ref="0" bb="32" group="95" />
+                          </Parameter>
+                          <Parameter id="CFoO3BTxZke4WtYXtGnciQ" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.456">
+                            <ValueOrigin id="22" source="Publication" description="Rodgers T, Rowland M. Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J Pharm Sci. 2006 Jun;95(6):1238-57 https://doi.org/10.1002/jps.20502" />
+                            <Info min="0" max="1" flag="122" seq="603" ref="0" bb="32" group="92" />
+                          </Parameter>
+                          <Parameter id="lEy6H7c96U-VFDBZNax3sQ" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.78">
+                            <Info min="0" max="1" flag="122" seq="603" ref="0" bb="32" group="95" />
+                          </Parameter>
+                          <Parameter id="GZqaSyzwdkqiM-Fd4sJnUA" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.41">
+                            <ValueOrigin id="21" source="Publication" description="Rodgers T, Leahy D, Rowland M. Physiologically based pharmacokinetic modeling 1: predicting the tissue distribution of moderate-to-strong bases. J Pharm Sci. 2005 Jun;94(6):1259-76. https://doi.org/10.1002/jps.20322" />
+                            <Info min="0" max="1000" flag="122" seq="604" ref="0" bb="32" group="92" />
+                          </Parameter>
+                          <Parameter id="RSWRs-6-40KOsWDFrmLuCQ" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0035">
+                            <Info min="0" max="1" flag="122" seq="604" ref="0" bb="32" group="95" />
+                          </Parameter>
+                          <Container id="NnYDxAvR50id6cKL1JK05A" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
+                            <Tags>
+                              <Tag value="ColonSigmoid" />
+                              <Tag value="LargeIntestineSegment" />
+                              <Tag value="Mucosa" />
+                            </Tags>
+                            <Children>
+                              <Parameter id="EQrUqAATUkaXAY1bcPL48w" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="jUuicTjwYECqpkpEHOcv6w" isDefault="1" displayUnit="l">
+                                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                              </Parameter>
+                              <Parameter id="Gv208GP85U-4m8YaFNBJ6Q" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="2ErPZJcYvUyL3QogRRKmZg" isDefault="1" displayUnit="l">
+                                <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                                <Info min="0" flag="62" seq="120" ref="0" bb="2" group="126" />
+                              </Parameter>
+                              <Container id="W3ERIw8b7E2xF8GNPp_26Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
+                                <Children>
+                                  <Parameter id="PT-bE-6mV0uGHwhGIk87SQ" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_o63arufdk2PTQFsOiSkqg" isDefault="1">
+                                    <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                                  </Parameter>
+                                  <Parameter id="X4gnEMotDES52vxNpQh9Kw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="pDRD-WocckCSQtVxG1Keug" isDefault="1">
+                                    <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                                  </Parameter>
+                                  <Parameter id="DJWPIwu1X02-jFfxM_6KnQ" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="YQERj92sg0eOeddA3tJEnw" isDefault="1" displayUnit="min">
+                                    <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                                  </Parameter>
+                                </Children>
+                              </Container>
+                            </Children>
+                          </Container>
+                          <Container id="9rh5uMJZKkCrCkUcs7GNfA" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
+                            <Tags>
+                              <Tag value="ColonSigmoid" />
+                              <Tag value="LargeIntestineSegment" />
+                              <Tag value="Mucosa" />
+                            </Tags>
+                            <Children>
+                              <Parameter id="lmS8RmfDakCFg1zZMQgMxQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="jUuicTjwYECqpkpEHOcv6w" isDefault="1" displayUnit="l">
+                                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                              </Parameter>
+                              <Parameter id="fy3yWH2xdkitp-4jcj1TKA" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="V2_FdO3puUGekuCdqn4lGg" isDefault="1" displayUnit="l">
+                                <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                                <Info min="0" flag="62" seq="120" ref="0" bb="2" group="121" />
+                              </Parameter>
+                              <Container id="uaeNYZs_80mpAza3wWfARg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
+                                <Children>
+                                  <Parameter id="rehSv9x7WkibS_r6isOZQA" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_o63arufdk2PTQFsOiSkqg" isDefault="1">
+                                    <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                                  </Parameter>
+                                  <Parameter id="Eg69apITUUujJdwsv-Nw5Q" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_B4r1Pf9BEa0ce4IJUo7mA" isDefault="1">
+                                    <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                                  </Parameter>
+                                  <Parameter id="nQWZO2O2qUCEJvPDJy62iw" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="YQERj92sg0eOeddA3tJEnw" isDefault="1" displayUnit="min">
+                                    <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                                  </Parameter>
+                                </Children>
+                              </Container>
+                            </Children>
+                          </Container>
+                          <Container id="-BJYLLzaN0GrVt8nmTiwTQ" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
+                            <Tags>
+                              <Tag value="ColonSigmoid" />
+                              <Tag value="LargeIntestineSegment" />
+                              <Tag value="Mucosa" />
+                            </Tags>
+                            <Children>
+                              <Parameter id="iu1mxLx73UqprOtyWAKsAw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="jUuicTjwYECqpkpEHOcv6w" isDefault="1" displayUnit="l">
+                                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                              </Parameter>
+                              <Parameter id="ITU6KEub_0uVotlGWZuFUQ" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="FsvYOeKl5kaJQ1JZ4JcXpg" isDefault="1" displayUnit="l">
+                                <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                                <Info min="0" flag="62" seq="120" ref="0" bb="2" group="124" />
+                              </Parameter>
+                              <Parameter id="J14v9nwlukGzS0t5aM4mmQ" name="pH" description="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="vNehtSpde0yreA4KgSiy2A" isDefault="1">
+                                <Tags>
+                                  <Tag value="ColonSigmoid" />
+                                  <Tag value="LargeIntestineSegment" />
+                                  <Tag value="Mucosa" />
+                                </Tags>
+                                <Info min="0" max="14" flag="122" seq="362" ref="0" bb="32" group="84" />
+                              </Parameter>
+                              <Container id="tolbtwmBz0i9TMQMA233kA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
+                                <Children>
+                                  <Parameter id="jT8eJyQDkUyLY9O0gH2BYQ" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_o63arufdk2PTQFsOiSkqg" isDefault="1">
+                                    <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                                  </Parameter>
+                                  <Parameter id="VCdU2-_fi0igzP8G-qjaOw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="lJjPXHaf3kiIsrYG_mZMiA" isDefault="1">
+                                    <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                                  </Parameter>
+                                  <Parameter id="hKDyAICwW02T1usyl1zo9w" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="YQERj92sg0eOeddA3tJEnw" isDefault="1" displayUnit="min">
+                                    <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                                  </Parameter>
+                                </Children>
+                              </Container>
+                            </Children>
+                          </Container>
+                          <Container id="mN0sgeauwEOO8CBAEY9_3g" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
+                            <Tags>
+                              <Tag value="ColonSigmoid" />
+                              <Tag value="IntestinalSecretionSource" />
+                              <Tag value="LargeIntestineSegment" />
+                              <Tag value="Mucosa" />
+                            </Tags>
+                            <Children>
+                              <Parameter id="cS-RQe5SKkat6Wdwp9eoBA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="-ijMbq55KEWxwtKNegWm3g" isDefault="1" displayUnit="l">
+                                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                              </Parameter>
+                              <Parameter id="7llej3FeQk2T6fVRkgn7Aw" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="nGzrbq1s0U6FgEbhM3oFgQ" isDefault="1" displayUnit="l">
+                                <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                                <Info min="0" flag="62" seq="120" ref="0" bb="2" group="125" />
+                              </Parameter>
+                              <Parameter id="zAUKyH23akS0KBWBVhNxdA" name="pH" description="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.3">
+                                <Tags>
+                                  <Tag value="ColonSigmoid" />
+                                  <Tag value="IntestinalSecretionSource" />
+                                  <Tag value="LargeIntestineSegment" />
+                                  <Tag value="Mucosa" />
+                                </Tags>
+                                <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
+                                <Info min="0" max="14" flag="122" seq="362" ref="0" bb="32" group="83" />
+                              </Parameter>
+                              <Container id="yoz-Hf6jiUiwCNYhaRHt-g" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
+                                <Children>
+                                  <Parameter id="MfQ4bwN9sU6AgU6AoxE1Dw" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_o63arufdk2PTQFsOiSkqg" isDefault="1">
+                                    <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                                  </Parameter>
+                                  <Parameter id="kLKehU2fnE2sZfcSvmKmVA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="35S7wpNxpU-nMUyL5eSU2A" isDefault="1">
+                                    <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                                  </Parameter>
+                                  <Parameter id="TJeoNCBqw0iJ4RpC3lGiJA" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="YQERj92sg0eOeddA3tJEnw" isDefault="1" displayUnit="min">
+                                    <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
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+                            </Children>
+                          </Container>
+                          <Container id="2Zdsmk50i027gjGddWGGaA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule" />
+                        </Children>
+                      </Container>
+                      <Container id="hGiUjjhtmEGzSFOYmRHimw" name="Rectum" description="Rectum" icon="Rectum" mode="Logical" containerType="Compartment">
+                        <Children>
+                          <Parameter id="3JlKKQ6kHkqpBjEPX_O7ug" name="Weight (tissue)" description="Weight of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="wccWBS9A2kuoeEsL1_z2ww" isDefault="1" displayUnit="kg">
+                            <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
+                          </Parameter>
+                          <Parameter id="TfzB4StF8Uu-biysRsh9sw" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="S0PgbWWoN0ufdVuBzLG-0g" isDefault="1" displayUnit="l">
+                            <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
+                            <Info min="0" flag="122" seq="30" ref="0" bb="32" group="65" />
+                          </Parameter>
+                          <Parameter id="9PjMuSWu-0CWSTERRCS87g" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="043DNcStI0-iJ7SmugQrkQ" isDefault="1" displayUnit="l/min">
+                            <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                            <Info min="0" flag="122" seq="121" ref="0" bb="32" group="27" />
+                          </Parameter>
+                          <Parameter id="8otvz3_upEu4nU8aScFUaQ" name="Lymph flow rate" description="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="oycYaJK_AUabQcZsxoWAsA" isDefault="1" displayUnit="l/min">
+                            <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                            <Info min="0" flag="122" seq="121" ref="0" bb="32" group="58" />
+                          </Parameter>
+                          <Parameter id="OZdqcMHiokemUi2HCQzBDw" name="Volume (endothelium)" description="Volume of  vascular endothelium" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="HkR7HpI5skKWgOGO4zCbGg" isDefault="1" displayUnit="l">
+                            <Info min="0" flag="62" seq="121" ref="0" bb="32" group="127" />
+                          </Parameter>
+                          <Parameter id="9y-AJBCtykeCR9BMHeY8Wg" name="Blood flow rate" description="Organ blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="-59WJ32EKk6Yd8JvyG1b8Q" isDefault="1" displayUnit="l/min">
+                            <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
+                            <Info min="0" flag="122" seq="310" ref="0" bb="32" group="5" />
+                          </Parameter>
+                          <Parameter id="6QuTnUT0-EuviOui7RF5rQ" name="Fraction intracellular" description="Fraction of intracellular space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ZxHXV_JusU-NQSlrOekb3w" isDefault="1">
+                            <Info min="0" max="1" flag="46" seq="364" ref="0" bb="32" group="64" />
+                          </Parameter>
+                          <Parameter id="b-3srpHaKUGL1K_i1sCchA" name="Density (tissue)" description="Density of tissue" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
+                            <Info min="0" flag="38" seq="1" ref="0" bb="32" group="21" />
+                          </Parameter>
+                          <Parameter id="7gvysWY3SUStNjyGZ269iQ" name="Fraction mucosa" description="Mucosal fraction of regional intestinal tissue mass" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.3">
+                            <Info min="0" max="1" flag="122" seq="1" ref="0" bb="32" group="40" />
+                          </Parameter>
+                          <Parameter id="9CLGYVFadESBp1h4A5c1hQ" name="Fraction of regional blood flow rate" description="Regional blood flow fraction supplying the mucosal tissue of the segment" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.055">
+                            <Info min="0" flag="54" seq="1" ref="0" bb="32" group="39" />
+                          </Parameter>
+                          <Parameter id="QIFa2KDpEEGj8tQCwmZQVg" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                            <Info min="0" max="1" flag="54" seq="1" ref="0" bb="32" group="94" />
+                          </Parameter>
+                          <Parameter id="yyl11Mj3V0CwqibcDSXSaQ" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.05">
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+                            <Info min="0" max="1" flag="122" seq="121" ref="0" bb="32" group="114" />
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+                          <Parameter id="Tpu4x3Z81kaiSN9qhFLf0w" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" icon="Parameter" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.86944444444444E-10" displayUnit="ml/min/N">
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+                          <Parameter id="ssx06yL3wUO5xr0PUbNyYA" name="Fraction vascular" description="Fraction of vascular space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.08">
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+                          <Parameter id="-idcmoxNRU-Eod9fkbQfEA" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.06">
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+                            <Info min="0" max="1" flag="122" seq="363" ref="0" bb="32" group="85" />
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+                          <Parameter id="zIKUvv24qEykUr1YWJHQCQ" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0163">
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+                          <Parameter id="tvp1jI0_hEKngQKAMSQziQ" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.08">
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+                            <Info min="0" max="1" flag="122" seq="364" ref="0" bb="32" group="85" />
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+                          <Parameter id="RLcUXjO93k6XlwuwiyUgYQ" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.158">
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+                                    <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
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+                              <Tag value="LargeIntestineSegment" />
+                              <Tag value="Mucosa" />
+                              <Tag value="Rectum" />
+                            </Tags>
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+                                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
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+                                    <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
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+                                  <Parameter id="URbC5dJQlUi_uNBbnfVOoA" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="YQERj92sg0eOeddA3tJEnw" isDefault="1" displayUnit="min">
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+                              <Tag value="LargeIntestineSegment" />
+                              <Tag value="Mucosa" />
+                              <Tag value="Rectum" />
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+                              <Parameter id="JryYGjGoRkmbGICPB-UN4w" name="pH" description="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="vNehtSpde0yreA4KgSiy2A" isDefault="1">
+                                <Tags>
+                                  <Tag value="LargeIntestineSegment" />
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+                                <Info min="0" max="14" flag="122" seq="365" ref="0" bb="32" group="84" />
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+                                    <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
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+                                  <Parameter id="YQZb_XPonkuyamPg-0xiyg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TQlkP_blh0KMZiGVpQwlGg" isDefault="1">
+                                    <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
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+                                  <Parameter id="zE_onLTp2kGBhIt3ENoO8Q" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="YQERj92sg0eOeddA3tJEnw" isDefault="1" displayUnit="min">
+                                    <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
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+                              <Tag value="IntestinalSecretionSource" />
+                              <Tag value="LargeIntestineSegment" />
+                              <Tag value="Mucosa" />
+                              <Tag value="Rectum" />
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+                              <Parameter id="xmlQqkBNfEaFneqRd4q2AQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="-ijMbq55KEWxwtKNegWm3g" isDefault="1" displayUnit="l">
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+                              <Parameter id="hjYscshEzUK-871AjOGxvQ" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="nGzrbq1s0U6FgEbhM3oFgQ" isDefault="1" displayUnit="l">
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+                                <Tags>
+                                  <Tag value="IntestinalSecretionSource" />
+                                  <Tag value="LargeIntestineSegment" />
+                                  <Tag value="Mucosa" />
+                                  <Tag value="Rectum" />
+                                </Tags>
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+              <Container id="T0Mm5rwfEEGvMgAUNZA6HA" name="Liver" description="Liver" icon="Liver" mode="Logical" containerType="Organ">
+                <Children>
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+                  <Parameter id="15uUtIpPfUmS1K63KXaYEg" name="EHC continuous fraction" description="Fraction of biliary secreted compound continuously entering the duodenum without being temporarily stored in the gallbladder. The fraction of hepatic bile directly entering the duodenum is species-dependent and amounts to about 30-50% in fasted humans to 100% in rats, because the rat lacks a gallbladder." icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0">
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+                    <Info min="0" max="1" flag="54" seq="1" ref="0" bb="32" group="94" />
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+                  </Parameter>
+                  <Parameter id="Q0_kEBtUS06o6zFGnd8W9g" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.68">
+                    <Info min="0" max="1" flag="122" seq="88" ref="0" bb="32" group="95" />
+                  </Parameter>
+                  <Parameter id="JM355vshv0qnODiVNKoIDg" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="4.56">
+                    <ValueOrigin id="21" source="Publication" description="Rodgers T, Leahy D, Rowland M. Physiologically based pharmacokinetic modeling 1: predicting the tissue distribution of moderate-to-strong bases. J Pharm Sci. 2005 Jun;94(6):1259-76. https://doi.org/10.1002/jps.20322" />
+                    <Info min="0" max="1000" flag="122" seq="89" ref="0" bb="32" group="92" />
+                  </Parameter>
+                  <Parameter id="ziaJ-YEkvUGI2lyKhfKv4A" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0088">
+                    <Info min="0" max="1" flag="122" seq="89" ref="0" bb="32" group="95" />
+                  </Parameter>
+                  <DistributedParameter id="HBwo8EnlskitkxnIPs9vfg" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="SN1fiYDhMkqWgo_n_gnxqQ" mode="Logical" isDefault="1" displayUnit="l">
+                    <Children>
+                      <Parameter id="XJEISymeckG5Nq7AOZ61uA" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.513760933563919">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="65" />
+                      </Parameter>
+                      <Parameter id="23O5MxJtN0qybDYfbNuJTA" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.3578466712" displayUnit="l">
+                        <Info min="0" flag="34" seq="1" ref="0" bb="32" group="65" />
+                      </Parameter>
+                      <Parameter id="c8FemuyPh0mhV3MN0lR9Lg" name="Deviation" description="Standard deviation of Normal distribution" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.551406891692952" displayUnit="l">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="65" />
+                      </Parameter>
+                    </Children>
+                    <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
+                    <Info min="0" flag="106" seq="9" ref="0" bb="32" group="65" />
+                  </DistributedParameter>
+                  <DistributedParameter id="FqIUp6JE10iJW421I3cj0A" name="Specific blood flow rate" description="Blood flow rate normalized to the organ volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" formula="Y5BBWkGV4ESjXGe2nFdVpQ" mode="Logical" isDefault="1" displayUnit="ml/min/100g organ">
+                    <Children>
+                      <Parameter id="WB8tztq1rUmwsOZ9E7rsJQ" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="5" />
+                      </Parameter>
+                      <Parameter id="VnpNQakvC0m5x-1pwg8ZlA" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.1794" displayUnit="ml/min/100g organ">
+                        <Info min="0" flag="50" seq="1" ref="0" bb="32" group="5" />
+                      </Parameter>
+                      <Parameter id="P3A7U5_cXUK3eDgmKoA0PQ" name="Deviation" description="Standard deviation of Normal distribution" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.00897" displayUnit="ml/min/100g organ">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="5" />
+                      </Parameter>
+                    </Children>
+                    <ValueOrigin id="40" source="Publication" description="Edginton, A.N., Schmitt, W. &amp; Willmann, S. Clin Pharmacokinet (2006) 45: 1013. https://doi.org/10.2165/00003088-200645100-00005" />
+                    <Info min="0" flag="122" seq="141" ref="0" bb="32" group="5" />
+                  </DistributedParameter>
+                  <Container id="ECFuO3Q-EE6lTfhF7Nft2g" name="Periportal" description="Liver Periportal" icon="Periportal" mode="Logical" containerType="Compartment">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="i1npUHdC70WUz_s3fRMV7w" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="NeZcEvDV_k2GhukQNLpbeQ" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0.75" max="0.75" flag="54" seq="1" ref="0" bb="32" group="2" />
+                      </Parameter>
+                      <Parameter id="Q001NRRNC0GKfRr_amvzKA" name="Density (tissue)" description="Density of tissue" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" formula="ydre17hfLU2Y1u6A4uOXdg" isDefault="1" displayUnit="g/cm³">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" flag="38" seq="1" ref="0" bb="32" group="21" />
+                      </Parameter>
+                      <Parameter id="37JtKdbKlUCJftDGVuBdlg" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="bmActhe4rUCfHNoeEPn1hQ" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="1" ref="0" bb="32" group="94" />
+                      </Parameter>
+                      <Parameter id="lXtX6bINkU2bY2o_sGOl-w" name="Weight (tissue)" description="Weight of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="wccWBS9A2kuoeEsL1_z2ww" isDefault="1" displayUnit="kg">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
+                      </Parameter>
+                      <Parameter id="qaWqUTpX3kqeoen9qng-nQ" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="0uVIwHTGPUqHosZbUkXEDQ" isDefault="1" displayUnit="l">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" flag="62" seq="9" ref="0" bb="32" group="65" />
+                      </Parameter>
+                      <Parameter id="pD7blMyRZkCuSZISG0bP5Q" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="cY_6PA10eUKbEe2AxEgWcw" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="17" ref="0" bb="32" group="114" />
+                      </Parameter>
+                      <Parameter id="4edvJDEXf0K4oKuJzQOEbQ" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="iShmPT0Zc02yNJRaJoQ2_Q" isDefault="1" displayUnit="l/min">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                        <Info min="0" flag="62" seq="17" ref="0" bb="32" group="27" />
+                      </Parameter>
+                      <Parameter id="W8nf9Ig_3kevX9F1FBWUVA" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" icon="Parameter" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" negativeValuesAllowed="1" formula="zURrstlIAEGi-Ju0VvdVyw" isDefault="1" displayUnit="ml/min/N">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" flag="54" seq="17" ref="0" bb="32" group="115" />
+                      </Parameter>
+                      <Parameter id="CfwQtaQ9ME2ymEWph99LKw" name="Lymph flow rate" description="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="-0rrymhN3kiBrD_2WTaAUA" isDefault="1" displayUnit="l/min">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                        <Info min="0" flag="62" seq="17" ref="0" bb="32" group="58" />
+                      </Parameter>
+                      <Parameter id="0gIn4gxU_U2D3Et4b63d1g" name="Radius (large pores)" description="Large endothelial pores radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="PmzDG-5WrUKeEKUeghSYpA" isDefault="1" displayUnit="µm">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" flag="54" seq="17" ref="0" bb="32" group="55" />
+                      </Parameter>
+                      <Parameter id="irHEDjCbBEWieouoJvPMZg" name="Radius (small pores)" description="Small endothelial pores radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="VNBb2-2WG0CAxCny20P5Ug" isDefault="1" displayUnit="µm">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" flag="54" seq="17" ref="0" bb="32" group="99" />
+                      </Parameter>
+                      <Parameter id="0QcC-yuOUkO6EeVtuWvsnA" name="Volume (endothelium)" description="Volume of  vascular endothelium" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="Pzpz4blB-0aJaLhbIVrogg" isDefault="1" displayUnit="l">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" flag="62" seq="17" ref="0" bb="32" group="127" />
+                      </Parameter>
+                      <Parameter id="MDEkkYQ37Ue7DYiACC2fSg" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="w1AxDT0MGE-AoYigSYDnEg" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="51" ref="0" bb="32" group="85" />
+                      </Parameter>
+                      <Parameter id="hkkF9zbjLEO-gJO0XcUU9w" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="fKCGKyQp4EaaX2xZG1-ceQ" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="51" ref="0" bb="32" group="86" />
+                      </Parameter>
+                      <Parameter id="D4addNHcOE-HkI4zl0NMew" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="X5smbsmZ3EGDbyakvHANHQ" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="52" ref="0" bb="32" group="86" />
+                      </Parameter>
+                      <Parameter id="cbvnbk5fAE-zExd5VOFIJw" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="fLHeycB2bEaF4A0Inolp_w" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="52" ref="0" bb="32" group="85" />
+                      </Parameter>
+                      <Parameter id="2LGDrdWmmk2ymZce6KzKIA" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="aaabYn8N3UeY1uohZvChmA" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="53" ref="0" bb="32" group="111" />
+                      </Parameter>
+                      <Parameter id="TKcB2JwD60KRarVJTftXwQ" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="x0d20DoAREqDXee2afnajw" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="53" ref="0" bb="32" group="112" />
+                      </Parameter>
+                      <Parameter id="qylf2_843E6y5XX1oid7vA" name="Fraction vascular" description="Fraction of vascular space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="pkCiDsaPZ0iMOw-UhqOYPg" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="53" ref="0" bb="32" group="64" />
+                      </Parameter>
+                      <Parameter id="TsVsartiRkOlbft2IChqXg" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="wQLOzVc_fEq-qzhq7Ni_5w" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="53" ref="0" bb="32" group="113" />
+                      </Parameter>
+                      <Parameter id="0Y4Pu3bS30-By1BNnX-Hjg" name="Microsomal protein mass/g tissue" description="Microsomal protein content per gram tissue" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass per tissue" quantityType="Parameter" negativeValuesAllowed="1" formula="a5E9vQHGeU2K-aC2SYlYJw" isDefault="1" displayUnit="mg/g">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="53" ref="0" bb="32" group="59" />
+                      </Parameter>
+                      <Parameter id="aZNYNcJDr0WGCSyocUNBuA" name="Number of cells/g tissue" description="Number of cells per gram tissue" icon="Parameter" persistable="0" isFixedValue="0" dim="Count per mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Ije5FafDSEmFC1TrFSEEfA" isDefault="1" displayUnit="x10^6/g">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1000000" flag="54" seq="53" ref="0" bb="32" group="61" />
+                      </Parameter>
+                      <Parameter id="HZkz6Nnd2k-QxXWbdbaWTg" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="1aiq4aWndk-jsSgEPTDQkA" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="53" ref="0" bb="32" group="85" />
+                      </Parameter>
+                      <Parameter id="NCTBojz72EyDmE9Z3-ALaQ" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="j8XRW8KFrkGxoTVtyYJqzw" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="53" ref="0" bb="32" group="86" />
+                      </Parameter>
+                      <Parameter id="-i5d7ncUvEOZqGHo99nluw" name="Fraction intracellular" description="Fraction of intracellular space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="nwDLN_ltPECLMJnNdvfljA" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="56" ref="0" bb="32" group="64" />
+                      </Parameter>
+                      <Parameter id="n126yP9o_UWrmmjjVZcntw" name="Fraction interstitial" description="Fraction of interstitial space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="eYpiQeKFGEqXYXCKtnk_cA" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="59" ref="0" bb="32" group="64" />
+                      </Parameter>
+                      <Parameter id="201F6Ccz10ui4ksTG-mHmg" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="YzBUzujmW0WjO9MEoqLikw" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="85" ref="0" bb="32" group="92" />
+                      </Parameter>
+                      <Parameter id="NcVvF3JovU6Wi72yAPZN3w" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="N85nhFuI4UGWkHaBKLaG5w" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="85" ref="0" bb="32" group="95" />
+                      </Parameter>
+                      <Parameter id="7mR-iFH71EqUL3s-9c6QyA" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="z3VOO6JxMEGFSgrldeBqew" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="86" ref="0" bb="32" group="92" />
+                      </Parameter>
+                      <Parameter id="c0QrUp-JyE-EkWow_B8Gew" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cel8C141V02p7XVbyYN37w" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="86" ref="0" bb="32" group="95" />
+                      </Parameter>
+                      <Parameter id="zwOsN1wvbUW0U5l3ddVgiA" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="d2LO3Ks77EiZsadRqIdWLQ" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="87" ref="0" bb="32" group="92" />
+                      </Parameter>
+                      <Parameter id="VHBFZMJorUO5SJDX1Oyuiw" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="yle2gjYraEacdW2qiPLbLQ" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="87" ref="0" bb="32" group="95" />
+                      </Parameter>
+                      <Parameter id="IIfSz2lk_066SgV8LYgksQ" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="G8Cf0Ao8A0Ox1edIqHdong" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="88" ref="0" bb="32" group="92" />
+                      </Parameter>
+                      <Parameter id="qGwYU5QCNk66TIlW8PtkfQ" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="6PZrkK73fUu4egAAYcPDWQ" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="88" ref="0" bb="32" group="95" />
+                      </Parameter>
+                      <Parameter id="gu8yzR0zs0CONgsQe6uwMA" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ATjLIunwTkm9POavCPbZ3A" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1000" flag="54" seq="89" ref="0" bb="32" group="92" />
+                      </Parameter>
+                      <Parameter id="NhRFB_MEBES0-u7bt_k96g" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Yly7irfBSEONRwzpzT5E6Q" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="89" ref="0" bb="32" group="95" />
+                      </Parameter>
+                      <Parameter id="uilvhwzoPkKsT-wQ32l9Dw" name="Specific blood flow rate" description="Blood flow rate normalized to the organ volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" formula="DT2JfrOfbk2yefIXFv3R4w" isDefault="1" displayUnit="ml/min/100g organ">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" flag="54" seq="141" ref="0" bb="32" group="5" />
+                      </Parameter>
+                      <Parameter id="AkBsMeoZz0aFecNjul7UYw" name="Blood flow rate" description="Organ blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="nwgnUPIRXU2glCSHdwRh1A" isDefault="1" displayUnit="l/min">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" flag="54" seq="142" ref="0" bb="32" group="5" />
+                      </Parameter>
+                      <Container id="23PubB3JsEmwt4zxO6YDIw" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
+                        <Tags>
+                          <Tag value="Liver" />
+                          <Tag value="Periportal" />
+                        </Tags>
+                        <Children>
+                          <Parameter id="rGtrYU9Ty0yb-MUS415QlQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="jUuicTjwYECqpkpEHOcv6w" isDefault="1" displayUnit="l">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Parameter id="Rhfx9EC4sUilYEKE4B7HiQ" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="2ErPZJcYvUyL3QogRRKmZg" isDefault="1" displayUnit="l">
+                            <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                            <Info min="0" flag="62" seq="17" ref="0" bb="2" group="126" />
+                          </Parameter>
+                          <Container id="v7HkGtyfo0ijk6jAYct9CA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
+                            <Children>
+                              <Parameter id="kYtycrp_9Emq-reDocJ7BA" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_o63arufdk2PTQFsOiSkqg" isDefault="1">
+                                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                              </Parameter>
+                              <Parameter id="p8J9oYc8LkmdX5KGFVpAWw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="pDRD-WocckCSQtVxG1Keug" isDefault="1">
+                                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                              </Parameter>
+                              <Parameter id="koJO5HE6dUC2LX_syVDigQ" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="3PTNCKfDA0yr8QD63uBncQ" isDefault="1" displayUnit="min">
+                                <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                              </Parameter>
+                            </Children>
+                          </Container>
+                        </Children>
+                      </Container>
+                      <Container id="gN_9yZiLj0uUZO_KvTppTg" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
+                        <Tags>
+                          <Tag value="Liver" />
+                          <Tag value="Periportal" />
+                        </Tags>
+                        <Children>
+                          <Parameter id="1R87L6LbC0uN8TAbHe63eA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="jUuicTjwYECqpkpEHOcv6w" isDefault="1" displayUnit="l">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Parameter id="S8JRhJyvakypXZ3SBW4EMg" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="V2_FdO3puUGekuCdqn4lGg" isDefault="1" displayUnit="l">
+                            <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                            <Info min="0" flag="62" seq="17" ref="0" bb="2" group="121" />
+                          </Parameter>
+                          <Container id="HK_VU2eCH0eSCdZy3WAMpg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
+                            <Children>
+                              <Parameter id="TiSfywhcek62g4y5Xg2sOQ" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_o63arufdk2PTQFsOiSkqg" isDefault="1">
+                                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                              </Parameter>
+                              <Parameter id="Tc_k_dKbm0-5JH8es6OO7Q" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_B4r1Pf9BEa0ce4IJUo7mA" isDefault="1">
+                                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                              </Parameter>
+                              <Parameter id="4B8H0QsjBEG7HDQQ6BtlyA" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="3PTNCKfDA0yr8QD63uBncQ" isDefault="1" displayUnit="min">
+                                <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                              </Parameter>
+                            </Children>
+                          </Container>
+                        </Children>
+                      </Container>
+                      <Container id="iwcOYPQDV0icbjREmm0PAQ" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
+                        <Tags>
+                          <Tag value="Liver" />
+                          <Tag value="Periportal" />
+                        </Tags>
+                        <Children>
+                          <Parameter id="UhC_tAOkgEOfamYPg7b7FA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="jUuicTjwYECqpkpEHOcv6w" isDefault="1" displayUnit="l">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Parameter id="toIic41abU6C8_4td0Q40A" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="FsvYOeKl5kaJQ1JZ4JcXpg" isDefault="1" displayUnit="l">
+                            <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                            <Info min="0" flag="62" seq="17" ref="0" bb="2" group="124" />
+                          </Parameter>
+                          <Parameter id="Gjol4f-KwkWOq97cbAwOCA" name="pH" description="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="vNehtSpde0yreA4KgSiy2A" isDefault="1">
+                            <Tags>
+                              <Tag value="Liver" />
+                              <Tag value="Periportal" />
+                            </Tags>
+                            <Info min="0" max="14" flag="122" seq="54" ref="0" bb="32" group="84" />
+                          </Parameter>
+                          <Container id="Y8O5NgQnJ0WAxho1qbRs8Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
+                            <Children>
+                              <Parameter id="3ihIMHCPCEaUA2iggrR_aA" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_o63arufdk2PTQFsOiSkqg" isDefault="1">
+                                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                              </Parameter>
+                              <Parameter id="Q1qk7SeRWkq8is1C3O832g" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="-n4UAAfsu0OlQ6qJgR04VA" isDefault="1">
+                                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                              </Parameter>
+                              <Parameter id="MnXJdSdwbk-BQ7M_pAOmhQ" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="3PTNCKfDA0yr8QD63uBncQ" isDefault="1" displayUnit="min">
+                                <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                              </Parameter>
+                            </Children>
+                          </Container>
+                        </Children>
+                      </Container>
+                      <Container id="duoz3sQvW0G6Dhbi2qm2tA" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
+                        <Tags>
+                          <Tag value="Liver" />
+                          <Tag value="Periportal" />
+                        </Tags>
+                        <Children>
+                          <Parameter id="5u-4vdXnhE6mSZSMb4RPxQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="-ijMbq55KEWxwtKNegWm3g" isDefault="1" displayUnit="l">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Parameter id="I2n1TdqWb0qADuq3LYigng" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="nGzrbq1s0U6FgEbhM3oFgQ" isDefault="1" displayUnit="l">
+                            <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                            <Info min="0" flag="62" seq="17" ref="0" bb="2" group="125" />
+                          </Parameter>
+                          <Parameter id="iwC1NavKMEGHrmXnOWRSfA" name="pH" description="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="d7BtMBVNMkGBeGiAma7Ecg" isDefault="1">
+                            <Tags>
+                              <Tag value="Liver" />
+                              <Tag value="Periportal" />
+                            </Tags>
+                            <Info min="0" max="14" flag="122" seq="55" ref="0" bb="32" group="83" />
+                          </Parameter>
+                          <Container id="P18AHHb4BkiD5G21UVVZgw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
+                            <Children>
+                              <Parameter id="wO1F4Jz4iEaGSTkGuLGk9g" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_o63arufdk2PTQFsOiSkqg" isDefault="1">
+                                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                              </Parameter>
+                              <Parameter id="mPtjWxc1RkmR3KH-fC5ULg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="JfRMN4_lukyIUnFdWY7Qnw" isDefault="1">
+                                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                              </Parameter>
+                              <Parameter id="mTVbSBosgEqTjoPkCO2GJw" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="3PTNCKfDA0yr8QD63uBncQ" isDefault="1" displayUnit="min">
+                                <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                              </Parameter>
+                            </Children>
+                          </Container>
+                        </Children>
+                      </Container>
+                    </Children>
+                  </Container>
+                  <Container id="kXCGvqE90kyk9jRzevjP9g" name="Pericentral" description="Liver Pericentral" icon="Pericentral" mode="Logical" containerType="Compartment">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="0PGH5SYemkqY91_g2tdjEQ" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="NeZcEvDV_k2GhukQNLpbeQ" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0.75" max="0.75" flag="54" seq="1" ref="0" bb="32" group="2" />
+                      </Parameter>
+                      <Parameter id="JN5HNIH6_ECpD3OyPZjOYQ" name="Density (tissue)" description="Density of tissue" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" formula="ydre17hfLU2Y1u6A4uOXdg" isDefault="1" displayUnit="g/cm³">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" flag="38" seq="1" ref="0" bb="32" group="21" />
+                      </Parameter>
+                      <Parameter id="SXcrJAUVP0m3KIrkpvtzcQ" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="bmActhe4rUCfHNoeEPn1hQ" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="1" ref="0" bb="32" group="94" />
+                      </Parameter>
+                      <Parameter id="smYq3srnc0KiqsKO8OCwkA" name="Weight (tissue)" description="Weight of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="wccWBS9A2kuoeEsL1_z2ww" isDefault="1" displayUnit="kg">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
+                      </Parameter>
+                      <Parameter id="HCoC1j75l0iXSa9IoQqmqg" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="uep8Gnk-5E608GNzy_NVRA" isDefault="1" displayUnit="l">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" flag="62" seq="10" ref="0" bb="32" group="65" />
+                      </Parameter>
+                      <Parameter id="-TuI_FPhVEOTdQMmlgpFZA" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="cY_6PA10eUKbEe2AxEgWcw" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="17" ref="0" bb="32" group="114" />
+                      </Parameter>
+                      <Parameter id="cbTA6uXv8EGXlaW3Fd3o2Q" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" icon="Parameter" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" negativeValuesAllowed="1" formula="zURrstlIAEGi-Ju0VvdVyw" isDefault="1" displayUnit="ml/min/N">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" flag="54" seq="17" ref="0" bb="32" group="115" />
+                      </Parameter>
+                      <Parameter id="WHCM3zb--k6p2uzjN9rUhg" name="Radius (large pores)" description="Large endothelial pores radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="PmzDG-5WrUKeEKUeghSYpA" isDefault="1" displayUnit="µm">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" flag="54" seq="17" ref="0" bb="32" group="55" />
+                      </Parameter>
+                      <Parameter id="koFrhOX8R0aKqMWPWoybkg" name="Radius (small pores)" description="Small endothelial pores radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="VNBb2-2WG0CAxCny20P5Ug" isDefault="1" displayUnit="µm">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" flag="54" seq="17" ref="0" bb="32" group="99" />
+                      </Parameter>
+                      <Parameter id="S5Xt4xPLxUeHPZNwSleTLQ" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="_fqX8V3b10CVWJwpKyAKFg" isDefault="1" displayUnit="l/min">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                        <Info min="0" flag="62" seq="18" ref="0" bb="32" group="27" />
+                      </Parameter>
+                      <Parameter id="wLvCerCJWU6CtW1g8hdQdw" name="Lymph flow rate" description="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="48-Cm86vzEeAqMLKlF_SGw" isDefault="1" displayUnit="l/min">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                        <Info min="0" flag="62" seq="18" ref="0" bb="32" group="58" />
+                      </Parameter>
+                      <Parameter id="Acdz6qIWQ0KEOalyHWW8tQ" name="Volume (endothelium)" description="Volume of  vascular endothelium" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="h136HUqmKECLpy0j1kK2hA" isDefault="1" displayUnit="l">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" flag="62" seq="18" ref="0" bb="32" group="127" />
+                      </Parameter>
+                      <Parameter id="w798U1nJI0CtpOl5q469oQ" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="w1AxDT0MGE-AoYigSYDnEg" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="51" ref="0" bb="32" group="85" />
+                      </Parameter>
+                      <Parameter id="wWttEb4iK0CGHfVskrsTwA" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="fKCGKyQp4EaaX2xZG1-ceQ" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="51" ref="0" bb="32" group="86" />
+                      </Parameter>
+                      <Parameter id="_jGOfSowXUO-yUK_WWFBcw" name="Fraction vascular" description="Fraction of vascular space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="pkCiDsaPZ0iMOw-UhqOYPg" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="52" ref="0" bb="32" group="64" />
+                      </Parameter>
+                      <Parameter id="fwjM1wdjgEunauGWFl-p3A" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="X5smbsmZ3EGDbyakvHANHQ" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="52" ref="0" bb="32" group="86" />
+                      </Parameter>
+                      <Parameter id="UccBquT7d0erAIESMoSLgA" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="fLHeycB2bEaF4A0Inolp_w" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="52" ref="0" bb="32" group="85" />
+                      </Parameter>
+                      <Parameter id="R_a7nYrNdUa_KZ7DTfyaaA" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="aaabYn8N3UeY1uohZvChmA" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="53" ref="0" bb="32" group="111" />
+                      </Parameter>
+                      <Parameter id="l3sR0UhUFUOvwFCEnYkLgg" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="x0d20DoAREqDXee2afnajw" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="53" ref="0" bb="32" group="112" />
+                      </Parameter>
+                      <Parameter id="T2L_AHZQ902YtRxcd9LXKQ" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="wQLOzVc_fEq-qzhq7Ni_5w" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="53" ref="0" bb="32" group="113" />
+                      </Parameter>
+                      <Parameter id="wm5xaIKcGku9phX_830HKA" name="Microsomal protein mass/g tissue" description="Microsomal protein content per gram tissue" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass per tissue" quantityType="Parameter" negativeValuesAllowed="1" formula="a5E9vQHGeU2K-aC2SYlYJw" isDefault="1" displayUnit="mg/g">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="53" ref="0" bb="32" group="59" />
+                      </Parameter>
+                      <Parameter id="n-hSYW28FkqE7TbzpB_LVg" name="Number of cells/g tissue" description="Number of cells per gram tissue" icon="Parameter" persistable="0" isFixedValue="0" dim="Count per mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Ije5FafDSEmFC1TrFSEEfA" isDefault="1" displayUnit="x10^6/g">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1000000" flag="54" seq="53" ref="0" bb="32" group="61" />
+                      </Parameter>
+                      <Parameter id="Pb15j9lOAEOULh0Ypl-OgQ" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="1aiq4aWndk-jsSgEPTDQkA" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="53" ref="0" bb="32" group="85" />
+                      </Parameter>
+                      <Parameter id="PyfZeXfpDkSdU8kKw8pgVg" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="j8XRW8KFrkGxoTVtyYJqzw" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="53" ref="0" bb="32" group="86" />
+                      </Parameter>
+                      <Parameter id="5rc08UQFsUKnEa4CeBaFnA" name="Fraction intracellular" description="Fraction of intracellular space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="nwDLN_ltPECLMJnNdvfljA" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="55" ref="0" bb="32" group="64" />
+                      </Parameter>
+                      <Parameter id="QVnAnxut3k6AQJChDq4i4Q" name="Fraction interstitial" description="Fraction of interstitial space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="eYpiQeKFGEqXYXCKtnk_cA" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="58" ref="0" bb="32" group="64" />
+                      </Parameter>
+                      <Parameter id="qweUTgzNcUqTyMdWwXnqJg" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="YzBUzujmW0WjO9MEoqLikw" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="85" ref="0" bb="32" group="92" />
+                      </Parameter>
+                      <Parameter id="P4AzFsymnEymaYXSJ8RW8Q" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="N85nhFuI4UGWkHaBKLaG5w" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="85" ref="0" bb="32" group="95" />
+                      </Parameter>
+                      <Parameter id="nj3iJ4edtEChLxVp25aVWw" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="z3VOO6JxMEGFSgrldeBqew" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="86" ref="0" bb="32" group="92" />
+                      </Parameter>
+                      <Parameter id="Q1FrDTeoskS7NsjqX0y-wA" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cel8C141V02p7XVbyYN37w" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="86" ref="0" bb="32" group="95" />
+                      </Parameter>
+                      <Parameter id="kHMRoswYZk6T54e8c5GkSA" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="d2LO3Ks77EiZsadRqIdWLQ" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="87" ref="0" bb="32" group="92" />
+                      </Parameter>
+                      <Parameter id="aEdZbUIMMUuYhpTzQzV1gQ" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="yle2gjYraEacdW2qiPLbLQ" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="87" ref="0" bb="32" group="95" />
+                      </Parameter>
+                      <Parameter id="0DrqLKC8bEuaen7VDOVKUw" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="G8Cf0Ao8A0Ox1edIqHdong" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="88" ref="0" bb="32" group="92" />
+                      </Parameter>
+                      <Parameter id="9y3fw7QBmkCmjVVok0XPLQ" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="6PZrkK73fUu4egAAYcPDWQ" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="88" ref="0" bb="32" group="95" />
+                      </Parameter>
+                      <Parameter id="dGXAPo87UECxcOTqi2VGjw" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ATjLIunwTkm9POavCPbZ3A" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1000" flag="54" seq="89" ref="0" bb="32" group="92" />
+                      </Parameter>
+                      <Parameter id="fxeLCshU3ku2m2CEt7jMBA" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Yly7irfBSEONRwzpzT5E6Q" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="89" ref="0" bb="32" group="95" />
+                      </Parameter>
+                      <Parameter id="MEbK8q7Nu0q0o_fsjYanEw" name="Specific blood flow rate" description="Blood flow rate normalized to the organ volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" formula="DT2JfrOfbk2yefIXFv3R4w" isDefault="1" displayUnit="ml/min/100g organ">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" flag="54" seq="141" ref="0" bb="32" group="5" />
+                      </Parameter>
+                      <Parameter id="_ykBAAqu2kWrMYPKgzPXXg" name="Blood flow rate" description="Organ blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="nwgnUPIRXU2glCSHdwRh1A" isDefault="1" displayUnit="l/min">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" flag="54" seq="142" ref="0" bb="32" group="5" />
+                      </Parameter>
+                      <Container id="4ON-uIC2yka_hwoIl3K68w" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
+                        <Tags>
+                          <Tag value="Liver" />
+                          <Tag value="Pericentral" />
+                        </Tags>
+                        <Children>
+                          <Parameter id="pvjCjcp1PEe8FxucVVGcBw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="jUuicTjwYECqpkpEHOcv6w" isDefault="1" displayUnit="l">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Parameter id="lnKbP8--iEadu9o7-X1ECQ" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="2ErPZJcYvUyL3QogRRKmZg" isDefault="1" displayUnit="l">
+                            <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                            <Info min="0" flag="62" seq="17" ref="0" bb="2" group="126" />
+                          </Parameter>
+                          <Container id="4dz0SpUGtUePjhmxKFgjiA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
+                            <Children>
+                              <Parameter id="NV2tHrOiL0SUjj_b46zvDQ" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_o63arufdk2PTQFsOiSkqg" isDefault="1">
+                                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                              </Parameter>
+                              <Parameter id="OsL-XL8e0UG6X2KjDLZEcQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="pDRD-WocckCSQtVxG1Keug" isDefault="1">
+                                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                              </Parameter>
+                              <Parameter id="vm0EyFEo9kGNAntKZaC28g" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="3PTNCKfDA0yr8QD63uBncQ" isDefault="1" displayUnit="min">
+                                <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                              </Parameter>
+                            </Children>
+                          </Container>
+                        </Children>
+                      </Container>
+                      <Container id="5bZh8mQG10-PXIrw1ZTguw" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
+                        <Tags>
+                          <Tag value="Liver" />
+                          <Tag value="Pericentral" />
+                        </Tags>
+                        <Children>
+                          <Parameter id="uLCrQ4SSPU2ANDtxpMrEyQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="jUuicTjwYECqpkpEHOcv6w" isDefault="1" displayUnit="l">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Parameter id="nNGzp6mPn0GOF7VIUasr5w" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="V2_FdO3puUGekuCdqn4lGg" isDefault="1" displayUnit="l">
+                            <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                            <Info min="0" flag="62" seq="17" ref="0" bb="2" group="121" />
+                          </Parameter>
+                          <Container id="q1xI0OMwY0yImBDvIFruRg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
+                            <Children>
+                              <Parameter id="AIAbs749_U-MGEzhYc2FzQ" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_o63arufdk2PTQFsOiSkqg" isDefault="1">
+                                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                              </Parameter>
+                              <Parameter id="3RsiIBN1M0ytI0ojjYhT6w" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_B4r1Pf9BEa0ce4IJUo7mA" isDefault="1">
+                                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                              </Parameter>
+                              <Parameter id="U9skUYb8oUuypPv1oV5bOA" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="3PTNCKfDA0yr8QD63uBncQ" isDefault="1" displayUnit="min">
+                                <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                              </Parameter>
+                            </Children>
+                          </Container>
+                        </Children>
+                      </Container>
+                      <Container id="OGrw2W605U2rhhi3U_alow" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
+                        <Tags>
+                          <Tag value="Liver" />
+                          <Tag value="Pericentral" />
+                        </Tags>
+                        <Children>
+                          <Parameter id="vScebGOIukOsyr7Kw-HrxQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="jUuicTjwYECqpkpEHOcv6w" isDefault="1" displayUnit="l">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Parameter id="5jEZx24_HU6o6EQC3pcfQA" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="FsvYOeKl5kaJQ1JZ4JcXpg" isDefault="1" displayUnit="l">
+                            <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                            <Info min="0" flag="62" seq="17" ref="0" bb="2" group="124" />
+                          </Parameter>
+                          <Parameter id="YUdgRkq7K0y5ksniv8DXIw" name="pH" description="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="vNehtSpde0yreA4KgSiy2A" isDefault="1">
+                            <Tags>
+                              <Tag value="Liver" />
+                              <Tag value="Pericentral" />
+                            </Tags>
+                            <Info min="0" max="14" flag="122" seq="55" ref="0" bb="32" group="84" />
+                          </Parameter>
+                          <Container id="ewnu9isH7UOfYV-QgJqeEg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
+                            <Children>
+                              <Parameter id="KUOxfquW-UaYFMEDzMiK0w" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_o63arufdk2PTQFsOiSkqg" isDefault="1">
+                                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                              </Parameter>
+                              <Parameter id="XqXb8CPzXUmoy2QuoCHj5A" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="-n4UAAfsu0OlQ6qJgR04VA" isDefault="1">
+                                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                              </Parameter>
+                              <Parameter id="zTtk3K47-kiBk6VqYhOE5w" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="3PTNCKfDA0yr8QD63uBncQ" isDefault="1" displayUnit="min">
+                                <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                              </Parameter>
+                            </Children>
+                          </Container>
+                        </Children>
+                      </Container>
+                      <Container id="1VLcjVXjU0Ohi8ry9Yp7AA" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
+                        <Tags>
+                          <Tag value="Liver" />
+                          <Tag value="Pericentral" />
+                        </Tags>
+                        <Children>
+                          <Parameter id="rqfUiG8emUOmrTaimQLaqg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="-ijMbq55KEWxwtKNegWm3g" isDefault="1" displayUnit="l">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Parameter id="1iET_nmigkajwJWVVSSayg" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="nGzrbq1s0U6FgEbhM3oFgQ" isDefault="1" displayUnit="l">
+                            <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                            <Info min="0" flag="62" seq="17" ref="0" bb="2" group="125" />
+                          </Parameter>
+                          <Parameter id="0dNFwDdMWUS-7wqj10rrwQ" name="pH" description="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="d7BtMBVNMkGBeGiAma7Ecg" isDefault="1">
+                            <Tags>
+                              <Tag value="Liver" />
+                              <Tag value="Pericentral" />
+                            </Tags>
+                            <Info min="0" max="14" flag="122" seq="56" ref="0" bb="32" group="83" />
+                          </Parameter>
+                          <Container id="dBE7Uz3ZNkaj_QWXPg7nUQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
+                            <Children>
+                              <Parameter id="xmUhDwG6rEiU3OcMvv7thw" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_o63arufdk2PTQFsOiSkqg" isDefault="1">
+                                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                              </Parameter>
+                              <Parameter id="6W4ol_xHDUSME48TtI2LRA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="JfRMN4_lukyIUnFdWY7Qnw" isDefault="1">
+                                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                              </Parameter>
+                              <Parameter id="Vaj4W_4umEeEj538QJMfdg" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="3PTNCKfDA0yr8QD63uBncQ" isDefault="1" displayUnit="min">
+                                <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                              </Parameter>
+                            </Children>
+                          </Container>
+                        </Children>
+                      </Container>
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+                  <Parameter id="z9ZRo23kn0K31ykNxO7LSA" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.11">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="92" ref="0" bb="32" group="95" />
+                  </Parameter>
+                  <Parameter id="9o5po0F8gUqbOUKDZqYodw" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.238">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="22" source="Publication" description="Rodgers T, Rowland M. Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J Pharm Sci. 2006 Jun;95(6):1238-57 https://doi.org/10.1002/jps.20502" />
+                    <Info min="0" max="1" flag="122" seq="93" ref="0" bb="32" group="92" />
+                  </Parameter>
+                  <Parameter id="5YbuKtQ1kkmONFKkF4YP5w" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.74">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="93" ref="0" bb="32" group="95" />
+                  </Parameter>
+                  <Parameter id="0KZX-a9iAUuUjyapnMKtow" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="3.91">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="21" source="Publication" description="Rodgers T, Leahy D, Rowland M. Physiologically based pharmacokinetic modeling 1: predicting the tissue distribution of moderate-to-strong bases. J Pharm Sci. 2005 Jun;94(6):1259-76. https://doi.org/10.1002/jps.20322" />
+                    <Info min="0" max="1000" flag="122" seq="94" ref="0" bb="32" group="92" />
+                  </Parameter>
+                  <Parameter id="2seOmCtdBEiMBopxNguPjw" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0044">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="94" ref="0" bb="32" group="95" />
+                  </Parameter>
+                  <DistributedParameter id="tyPwfrbfwkO_A3wh4bxNTw" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="28FNKG5n0Ea1yegcWETbwQ" mode="Logical" isDefault="1" displayUnit="l">
+                    <Children>
+                      <Parameter id="wLhpCCCSf0CXIgbCiUUj7Q" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.403636248736259">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="65" />
+                      </Parameter>
+                      <Parameter id="Zcq2OPAYZE6wqMFt2lqVGQ" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.2943497288" displayUnit="l">
+                        <Info min="0" flag="34" seq="1" ref="0" bb="32" group="65" />
+                      </Parameter>
+                      <Parameter id="ti22qH1MHEKT-ArEc9aAwA" name="GeometricDeviation" description="Geometric standard deviation of LogNormal distribution" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.3">
+                        <Info min="1" flag="18" seq="1" ref="0" bb="32" group="65" />
+                      </Parameter>
+                    </Children>
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
+                    <Info min="0" flag="106" seq="10" ref="0" bb="32" group="65" />
+                  </DistributedParameter>
+                  <DistributedParameter id="FtXUkb6EkUi96xECE7faFg" name="Fraction vascular" description="Fraction of vascular space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="HA3jP5ydYE6Pj8f48SF7hA" mode="Logical" isDefault="1">
+                    <Children>
+                      <Parameter id="1ZfUAIXlNUGZa03lyY0Q5Q" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="64" />
+                      </Parameter>
+                      <Parameter id="vO6hkcR4BUK6TTWppRmn3w" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.58">
+                        <Info min="0" max="1" flag="50" seq="1" ref="0" bb="32" group="64" />
+                      </Parameter>
+                    </Children>
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="40" source="Publication" description="Edginton, A.N., Schmitt, W. &amp; Willmann, S. Clin Pharmacokinet (2006) 45: 1013. https://doi.org/10.2165/00003088-200645100-00005" />
+                    <Info min="0" max="1" flag="62" seq="60" ref="0" bb="32" group="64" />
+                  </DistributedParameter>
+                  <Container id="ZZhPPTmN4UK9ZYEZpa3LFg" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
+                    <Tags>
+                      <Tag value="Lung" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="rBQvBLlCi0OCqfAUApFMug" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="jUuicTjwYECqpkpEHOcv6w" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="0yKfGlU8oE6V-0Z5A6r1FA" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="2ErPZJcYvUyL3QogRRKmZg" isDefault="1" displayUnit="l">
+                        <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                        <Info min="0" flag="62" seq="18" ref="0" bb="2" group="126" />
+                      </Parameter>
+                      <Container id="0i2gaWUPME-Fj5mRCyIiDw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
+                        <Children>
+                          <Parameter id="We4-eQUmX06gYO4US-5VBQ" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_o63arufdk2PTQFsOiSkqg" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                          </Parameter>
+                          <Parameter id="L36RqiCf1UqRl-sks8TfmQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="pDRD-WocckCSQtVxG1Keug" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                          </Parameter>
+                          <Parameter id="pcMWIWde5U6PVvLOdCfmTg" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="3PTNCKfDA0yr8QD63uBncQ" isDefault="1" displayUnit="min">
+                            <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                        </Children>
+                      </Container>
+                    </Children>
+                  </Container>
+                  <Container id="4-BftgHXdUGy3Tm3_NV1kA" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
+                    <Tags>
+                      <Tag value="Lung" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="iSUhsNMg3kWSZh3wlrFZSg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="jUuicTjwYECqpkpEHOcv6w" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="dhlGWtuaTkKQJ5ENcoWXEg" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="V2_FdO3puUGekuCdqn4lGg" isDefault="1" displayUnit="l">
+                        <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                        <Info min="0" flag="62" seq="18" ref="0" bb="2" group="121" />
+                      </Parameter>
+                      <Container id="oRucCPEwY0yHfBcUVMAsjA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
+                        <Children>
+                          <Parameter id="gQzSsCczF0azg3mDCDleyQ" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_o63arufdk2PTQFsOiSkqg" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                          </Parameter>
+                          <Parameter id="N-nZlq6gMUGrVdNfeXlH4Q" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_B4r1Pf9BEa0ce4IJUo7mA" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                          </Parameter>
+                          <Parameter id="TI_4tZbvjUmkCdF16cXRzg" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="3PTNCKfDA0yr8QD63uBncQ" isDefault="1" displayUnit="min">
+                            <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                        </Children>
+                      </Container>
+                    </Children>
+                  </Container>
+                  <Container id="9ckZpDyMwk6AKCwClTHdIw" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
+                    <Tags>
+                      <Tag value="Lung" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="CaLWbBoDskae1P1OUPzqEA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="jUuicTjwYECqpkpEHOcv6w" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="Rg4cJYL0eEmR5mjMwHb-NQ" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="FsvYOeKl5kaJQ1JZ4JcXpg" isDefault="1" displayUnit="l">
+                        <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                        <Info min="0" flag="62" seq="18" ref="0" bb="2" group="124" />
+                      </Parameter>
+                      <Parameter id="9zaC7qtomk-yhPU0wzeQBQ" name="pH" description="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="vNehtSpde0yreA4KgSiy2A" isDefault="1">
+                        <Tags>
+                          <Tag value="Lung" />
+                        </Tags>
+                        <Info min="0" max="14" flag="122" seq="56" ref="0" bb="32" group="84" />
+                      </Parameter>
+                      <Container id="GwXw6onBlUyDYKjNCIlBwQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
+                        <Children>
+                          <Parameter id="CEmQYEzQ-0-LHmLFKtsVbw" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_o63arufdk2PTQFsOiSkqg" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                          </Parameter>
+                          <Parameter id="r1njsZBwXkilKLHxaD9PuQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="T-vSZ42ckk6doAz7MZWtTw" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                          </Parameter>
+                          <Parameter id="ay7ZoxTJDEeksbOz6g6sdA" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="3PTNCKfDA0yr8QD63uBncQ" isDefault="1" displayUnit="min">
+                            <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                        </Children>
+                      </Container>
+                    </Children>
+                  </Container>
+                  <Container id="1NzsX0eh2kKlC_xJpZEnJw" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
+                    <Tags>
+                      <Tag value="Lung" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="3xlqZKWpaU-1c3EWxAcNug" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="-ijMbq55KEWxwtKNegWm3g" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="uvWGIBv8oEuRAnO8KNOSuA" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="nGzrbq1s0U6FgEbhM3oFgQ" isDefault="1" displayUnit="l">
+                        <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                        <Info min="0" flag="62" seq="18" ref="0" bb="2" group="125" />
+                      </Parameter>
+                      <Parameter id="bF2RPz9EiUeAfi5XzOTpdA" name="pH" description="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="6.6">
+                        <Tags>
+                          <Tag value="Lung" />
+                        </Tags>
+                        <ValueOrigin id="34" source="Publication" description="Toxicol In Vitro. 2008 Mar;22(2):457-67 https://doi.org/10.1016/j.tiv.2007.09.010" />
+                        <Info min="0" max="14" flag="122" seq="57" ref="0" bb="32" group="83" />
+                      </Parameter>
+                      <Container id="HE_d15Y9D02q51Smfq2_1Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
+                        <Children>
+                          <Parameter id="hXKQhGevFEKQLFMc0nJSyQ" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_o63arufdk2PTQFsOiSkqg" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                          </Parameter>
+                          <Parameter id="nhOjtW-G-Uie3jGfn23mgg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="E5oG2FbIMUOneOnjGHjBBA" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                          </Parameter>
+                          <Parameter id="miHdJVWLhU2kFTUXRI9YPQ" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="3PTNCKfDA0yr8QD63uBncQ" isDefault="1" displayUnit="min">
+                            <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                        </Children>
+                      </Container>
+                    </Children>
+                  </Container>
+                </Children>
+              </Container>
+              <Container id="Thg1MysYAkKZ4HJwcB7P8A" name="Muscle" description="Muscle" icon="Muscle" mode="Logical" containerType="Organ">
+                <Tags>
+                  <Tag value="TissueOrgan" />
+                </Tags>
+                <Children>
+                  <Parameter id="A0gz6Gpv_EmV8sbdQcFz3A" name="Weight (tissue)" description="Weight of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="wccWBS9A2kuoeEsL1_z2ww" isDefault="1" displayUnit="kg">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
+                  </Parameter>
+                  <Parameter id="Gg66rsYBfk2mE-KhH7pU0w" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="_1qGrWaZQ0-mf9ujtwqKng" isDefault="1" displayUnit="l/min">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="19" ref="0" bb="32" group="27" />
+                  </Parameter>
+                  <Parameter id="XcoHNil9F0Svv9xFEw6SIg" name="Lymph flow rate" description="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="wo_Oqj188kKCGN911xCrEw" isDefault="1" displayUnit="l/min">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="19" ref="0" bb="32" group="58" />
+                  </Parameter>
+                  <Parameter id="_CSYyYSlsUWHkzdOKorIFg" name="Volume (endothelium)" description="Volume of  vascular endothelium" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="FbJvejWKQEC2yJU-5mGB1A" isDefault="1" displayUnit="l">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="62" seq="19" ref="0" bb="32" group="127" />
+                  </Parameter>
+                  <Parameter id="VNaDOyyDfkOGsI8dbyFlmA" name="Fraction intracellular" description="Fraction of intracellular space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ZxHXV_JusU-NQSlrOekb3w" isDefault="1">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="62" seq="64" ref="0" bb="32" group="64" />
+                  </Parameter>
+                  <Parameter id="4g7_4u5kMU-qnkqZdzEhFw" name="Blood flow rate" description="Organ blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="kOPtX3xlRUyjlOOtEoP9Yg" isDefault="1" displayUnit="l/min">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="48" source="Other" description="Absolute value = specific value (i.e. value normalized to the volume of the organ) multiplied by the organ volume" />
+                    <Info min="0" flag="62" seq="162" ref="0" bb="32" group="5" />
+                  </Parameter>
+                  <Parameter id="fNiPfRVezke8NZOkwdCm0w" name="Density (tissue)" description="Density of tissue" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="38" seq="1" ref="0" bb="32" group="21" />
+                  </Parameter>
+                  <Parameter id="hu0JFpjuTkSYxs15nAXRcw" name="Fluid recirculation flow proportionality factor" description="proportionality factor linking fluid recirculation flow to lymph flow via small pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.292">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="27" />
+                  </Parameter>
+                  <Parameter id="urSDyoAA40GLKX0zW65ZNg" name="Lymph flow proportionality factor" description="Proportionality factor linking lymph flow to plasma flow" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.00201">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="58" />
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+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="65" />
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+                    <ValueOrigin id="46" source="Publication" description="Thiel C, Schneckener S, Krauss M, Ghallab A, Hofmann U, et al. A systematic evaluation of the use of physiologically based pharmacokinetic modeling for cross-species extrapolation. J Pharm Sci. 2015 Jan;104(1):191-206 https://doi.org/10.1002/jps.24214" />
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+                      <Tag value="TissueOrgan" />
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+                    <Info min="0" max="1" flag="122" seq="19" ref="0" bb="32" group="114" />
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+                    <Tags>
+                      <Tag value="TissueOrgan" />
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+                    <ValueOrigin id="23" source="Publication" description="Rodgers T, Rowland M. Mechanistic approaches to volume of distribution predictions: understanding the processes. Pharm Res. 2007 May;24(5):918-33. https://doi.org/10.1007/s11095-006-9210-3" />
+                    <Info min="0" max="1" flag="122" seq="96" ref="0" bb="32" group="92" />
+                  </DistributedParameter>
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+                    <Children>
+                      <Parameter id="dGBYlAKFFkKa1cAaPVWzAA" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="95" />
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+                      <Parameter id="3hP-ONsTeke5xHqOF2Htzg" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0042">
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+                      </Parameter>
+                    </Children>
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+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="96" ref="0" bb="32" group="95" />
+                  </DistributedParameter>
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+                    <Children>
+                      <Parameter id="PryhYl44i0e1l6jtJMt6xw" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="92" />
+                      </Parameter>
+                      <Parameter id="9wUaCyJiz0GCKn0Pui4P7A" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.079">
+                        <Info min="0" max="1" flag="50" seq="1" ref="0" bb="32" group="92" />
+                      </Parameter>
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+                    </Tags>
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+                  </DistributedParameter>
+                  <DistributedParameter id="9THj81LRqUuJRA6F8fCp1w" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="KjVjbpAwDEuOM3u3zOc62w" mode="Logical" isDefault="1">
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+                      <Parameter id="CIkUafj8IUKGUdJSq5y8TA" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
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+                    <Children>
+                      <Parameter id="zTpsh2SIQkOQOZu7oCnaXw" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="92" />
+                      </Parameter>
+                      <Parameter id="jV7mNwYMq0GzVTJRfPR2SA" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.666">
+                        <Info min="0" max="1" flag="50" seq="1" ref="0" bb="32" group="92" />
+                      </Parameter>
+                    </Children>
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="98" ref="0" bb="32" group="92" />
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+                    <Children>
+                      <Parameter id="i4D8i_83SUWjBSPeiRSEbg" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="95" />
+                      </Parameter>
+                      <Parameter id="RaDQOGXaYE6VqJtaD1GYhQ" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.76">
+                        <Info min="0" max="1" flag="50" seq="1" ref="0" bb="32" group="95" />
+                      </Parameter>
+                    </Children>
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="98" ref="0" bb="32" group="95" />
+                  </DistributedParameter>
+                  <DistributedParameter id="iPm152mTgUKZPIS7otPVdw" name="Specific blood flow rate" description="Blood flow rate normalized to the organ volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" formula="X22nwMziLk-0qpVRNyytCw" mode="Logical" isDefault="1" displayUnit="ml/min/100g organ">
+                    <Children>
+                      <Parameter id="oDfjbOjc9EKM1Nc7N1G9nA" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="5" />
+                      </Parameter>
+                      <Parameter id="mfxbGBhAw0azvORGyyj4wQ" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.03419" displayUnit="ml/min/100g organ">
+                        <Info min="0" flag="50" seq="1" ref="0" bb="32" group="5" />
+                      </Parameter>
+                      <Parameter id="2EkF0FcjU0WR6UDPXO9EIg" name="Deviation" description="Standard deviation of Normal distribution" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0017095" displayUnit="ml/min/100g organ">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="5" />
+                      </Parameter>
+                    </Children>
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="40" source="Publication" description="Edginton, A.N., Schmitt, W. &amp; Willmann, S. Clin Pharmacokinet (2006) 45: 1013. https://doi.org/10.2165/00003088-200645100-00005" />
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+                  </DistributedParameter>
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+                    <Tags>
+                      <Tag value="Muscle" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="hrdaKjpLck2Fgqj86RMjig" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="jUuicTjwYECqpkpEHOcv6w" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="uNtyRSXiqUmvNXtBMt20gg" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="2ErPZJcYvUyL3QogRRKmZg" isDefault="1" displayUnit="l">
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+                        <Info min="0" flag="62" seq="19" ref="0" bb="2" group="126" />
+                      </Parameter>
+                      <Container id="vym45Qo-4EqYIeLYfFdpqA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
+                        <Children>
+                          <Parameter id="RwEXdP12XE2qmLCi4vyThg" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_o63arufdk2PTQFsOiSkqg" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                          </Parameter>
+                          <Parameter id="obfv9QhJzkeiFpvZFAeAdw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="pDRD-WocckCSQtVxG1Keug" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                          </Parameter>
+                          <Parameter id="c9DNLn1jaUiGpnjiDmXp2g" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="3PTNCKfDA0yr8QD63uBncQ" isDefault="1" displayUnit="min">
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+                    <Tags>
+                      <Tag value="Muscle" />
+                    </Tags>
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+                      <Parameter id="Lt_fO8hzrE2awzueOT4Qng" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="jUuicTjwYECqpkpEHOcv6w" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
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+                      <Container id="tBAMdTqETUObASmoHMYLkQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
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+                          <Parameter id="TSmdfLm-cEqZfEuStIiXxg" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_o63arufdk2PTQFsOiSkqg" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
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+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
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+                            <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
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+                    <Tags>
+                      <Tag value="Muscle" />
+                    </Tags>
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+                      <Parameter id="PN0UvdIdnUiugcQSBDUFNg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="jUuicTjwYECqpkpEHOcv6w" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
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+                        <Tags>
+                          <Tag value="Muscle" />
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+                        <Info min="0" max="14" flag="122" seq="59" ref="0" bb="32" group="84" />
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+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
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+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
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+                            <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
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+                    <Tags>
+                      <Tag value="Muscle" />
+                    </Tags>
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+                      <Parameter id="DlJNrJrZpUep0KEBvmh4lw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="-ijMbq55KEWxwtKNegWm3g" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="dIIzPtflZU-tae8ew2Qs-g" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="nGzrbq1s0U6FgEbhM3oFgQ" isDefault="1" displayUnit="l">
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+                        <Info min="0" flag="62" seq="19" ref="0" bb="2" group="125" />
+                      </Parameter>
+                      <Parameter id="OOKSRPtGQEGzlsgRjQmwdw" name="pH" description="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="6.81">
+                        <Tags>
+                          <Tag value="Muscle" />
+                        </Tags>
+                        <ValueOrigin id="34" source="Publication" description="Toxicol In Vitro. 2008 Mar;22(2):457-67 https://doi.org/10.1016/j.tiv.2007.09.010" />
+                        <Info min="0" max="14" flag="122" seq="59" ref="0" bb="32" group="83" />
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+                      <Container id="tJ4UzxvDGECc9I_P9TYJwA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
+                        <Children>
+                          <Parameter id="GRzrVBxbxkmpaiVhd8m30w" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_o63arufdk2PTQFsOiSkqg" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
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+                          <Parameter id="1za3MGzNyk6B9iPXbBNE5A" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="-wpaO7dZgkCBE7jnVBFDJg" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                          </Parameter>
+                          <Parameter id="f-_FLbv2MEq4YAkCvruw5A" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="3PTNCKfDA0yr8QD63uBncQ" isDefault="1" displayUnit="min">
+                            <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
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+                    </Children>
+                  </Container>
+                </Children>
+              </Container>
+              <Container id="O2-0m3L1FUGgvdyyZucOaA" name="Pancreas" description="Pancreas" icon="Pancreas" mode="Logical" containerType="Organ">
+                <Tags>
+                  <Tag value="Portal Vein Supplying Organ" />
+                  <Tag value="TissueOrgan" />
+                </Tags>
+                <Children>
+                  <Parameter id="_cmiVcOzl0SAkgzVRj8Nlw" name="Weight (tissue)" description="Weight of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="wccWBS9A2kuoeEsL1_z2ww" isDefault="1" displayUnit="kg">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
+                  </Parameter>
+                  <Parameter id="TxHmgQGRDUOEken9qV4qqQ" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="_1qGrWaZQ0-mf9ujtwqKng" isDefault="1" displayUnit="l/min">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
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+                    <Info min="0" flag="122" seq="20" ref="0" bb="32" group="27" />
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+                  <Parameter id="Q4GqenkQOUO41_hQZU3ZBg" name="Lymph flow rate" description="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="wo_Oqj188kKCGN911xCrEw" isDefault="1" displayUnit="l/min">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
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+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
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+                    <Info min="0" flag="62" seq="20" ref="0" bb="32" group="127" />
+                  </Parameter>
+                  <Parameter id="VjHLldveeEOdZ2DIhGG7Rw" name="Fraction intracellular" description="Fraction of intracellular space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ZxHXV_JusU-NQSlrOekb3w" isDefault="1">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="62" seq="67" ref="0" bb="32" group="64" />
+                  </Parameter>
+                  <Parameter id="lBcw_CgQrUGRXMvmnqOcrQ" name="Blood flow rate" description="Organ blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="kOPtX3xlRUyjlOOtEoP9Yg" isDefault="1" displayUnit="l/min">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="48" source="Other" description="Absolute value = specific value (i.e. value normalized to the volume of the organ) multiplied by the organ volume" />
+                    <Info min="0" flag="62" seq="182" ref="0" bb="32" group="5" />
+                  </Parameter>
+                  <Parameter id="smMyJWf6yE6tfxks9UpLOQ" name="Density (tissue)" description="Density of tissue" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="38" seq="1" ref="0" bb="32" group="21" />
+                  </Parameter>
+                  <Parameter id="Tge7ho432EuViretsAoO-Q" name="Fluid recirculation flow proportionality factor" description="proportionality factor linking fluid recirculation flow to lymph flow via small pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.01">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="27" />
+                  </Parameter>
+                  <Parameter id="tnIQD4k4hky5JNjmMDTARA" name="Lymph flow proportionality factor" description="Proportionality factor linking lymph flow to plasma flow" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0303">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="58" />
+                  </Parameter>
+                  <Parameter id="KxZ27rsQLEub2MtswEbhoQ" name="Organ volume mouse" description="Organ volume mouse" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.00013" displayUnit="l">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="65" />
+                  </Parameter>
+                  <Parameter id="fU6kKnLnDESPmJlVvYKYWw" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.75">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0.75" max="0.75" flag="54" seq="1" ref="0" bb="32" group="2" />
+                  </Parameter>
+                  <Parameter id="cd6RNmMQzkWUr2IdJ6PTuQ" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="54" seq="1" ref="0" bb="32" group="94" />
+                  </Parameter>
+                  <Parameter id="_QlCSsuLQke9tbojYGnp0A" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.05">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" max="1" flag="122" seq="20" ref="0" bb="32" group="114" />
+                  </Parameter>
+                  <Parameter id="bXp945NdAkCtNTYKSwVFHQ" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" icon="Parameter" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="3.22222222222222E-11" displayUnit="ml/min/N">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="20" ref="0" bb="32" group="115" />
+                  </Parameter>
+                  <Parameter id="_CXpJ65Dzke_cVaTu_-Bmg" name="Radius (large pores)" description="Large endothelial pores radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.5E-07" displayUnit="µm">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="20" ref="0" bb="32" group="55" />
+                  </Parameter>
+                  <Parameter id="NyLxU5wfhEOpQP98czWGAA" name="Radius (small pores)" description="Small endothelial pores radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="4.5E-08" displayUnit="µm">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="20" ref="0" bb="32" group="99" />
+                  </Parameter>
+                  <Parameter id="jsukkSjshkCNFs7NRVgNWw" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.08">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
+                    <Info min="0" max="1" flag="122" seq="60" ref="0" bb="32" group="85" />
+                  </Parameter>
+                  <Parameter id="GitrHCnNWE-QbSufl6WLXA" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0403">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="60" ref="0" bb="32" group="86" />
+                  </Parameter>
+                  <Parameter id="vTRSd-K34UeUu99UxQYhgw" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.01067">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="61" ref="0" bb="32" group="86" />
+                  </Parameter>
+                  <Parameter id="lVpsbx6EIEWIxXs5jgYylQ" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.13">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
+                    <Info min="0" max="1" flag="122" seq="61" ref="0" bb="32" group="85" />
+                  </Parameter>
+                  <Parameter id="cHdrvs32GEG87La5RpfryQ" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.06">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="22" source="Publication" description="Rodgers T, Rowland M. Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J Pharm Sci. 2006 Jun;95(6):1238-57 https://doi.org/10.1002/jps.20502" />
+                    <Info min="0" max="1" flag="122" seq="62" ref="0" bb="32" group="111" />
+                  </Parameter>
+                  <Parameter id="uysvBgvkq0GT62aW9Nly_g" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="24" source="Publication" description="POULIN P, THEIL F. Prediction of Pharmacokinetics Prior to In Vivo Studies. 1. Mechanism-Based Prediction of Volume of Distribution. JOURNAL OF PHARMACEUTICAL SCIENCES, VOL. 91, NO. 1, JANUARY 2002" />
+                    <Info min="0" max="1" flag="122" seq="62" ref="0" bb="32" group="112" />
+                  </Parameter>
+                  <Parameter id="h4rz5gmKUUimh90uy8nOzQ" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.06">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
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+                    <Info min="0" max="1" flag="122" seq="62" ref="0" bb="32" group="113" />
+                  </Parameter>
+                  <Parameter id="mu8gUMJpSU28aOmmxp8T5g" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.71">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
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+                    </Tags>
+                    <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
+                    <Info min="0" max="1" flag="122" seq="62" ref="0" bb="32" group="85" />
+                  </Parameter>
+                  <Parameter id="P6Zu2qWk20aiB-A3OvlYMQ" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.71">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="62" ref="0" bb="32" group="86" />
+                  </Parameter>
+                  <Parameter id="XQajmxne20aJAWxY6SdBZg" name="Fraction vascular" description="Fraction of vascular space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.2">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="40" source="Publication" description="Edginton, A.N., Schmitt, W. &amp; Willmann, S. Clin Pharmacokinet (2006) 45: 1013. https://doi.org/10.2165/00003088-200645100-00005" />
+                    <Info min="0" max="1" flag="62" seq="66" ref="0" bb="32" group="64" />
+                  </Parameter>
+                  <Parameter id="EdCnkKg2HkaEJQ23lpz7YQ" name="Fraction interstitial" description="Fraction of interstitial space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.12">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="19" source="Publication" description="Kawai R, Lemaire M, Steimer JL, Bruelisauer A, Niederberger W, Rowland M. Physiologically based pharmacokinetic study on a cyclosporin derivative, SDZ IMM 125. J Pharmacokinet Biopharm. 1994 Oct;22(5):327-65." />
+                    <Info min="0" max="1" flag="62" seq="68" ref="0" bb="32" group="64" />
+                  </Parameter>
+                  <Parameter id="DlX8wivyhEG0rovbI4dRbA" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0403">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="22" source="Publication" description="Rodgers T, Rowland M. Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J Pharm Sci. 2006 Jun;95(6):1238-57 https://doi.org/10.1002/jps.20502" />
+                    <Info min="0" max="1" flag="122" seq="100" ref="0" bb="32" group="92" />
+                  </Parameter>
+                  <Parameter id="-lw_iLyPcEq6VLkeSMjYCA" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0403">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="100" ref="0" bb="32" group="95" />
+                  </Parameter>
+                  <Parameter id="Wq1zPZU08kiy7dhEq5ucqw" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.009">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
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+                    <ValueOrigin id="22" source="Publication" description="Rodgers T, Rowland M. Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J Pharm Sci. 2006 Jun;95(6):1238-57 https://doi.org/10.1002/jps.20502" />
+                    <Info min="0" max="1" flag="122" seq="101" ref="0" bb="32" group="92" />
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+                  <Parameter id="IR0Oma1JdkCfyndDkPk1cg" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.009">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="101" ref="0" bb="32" group="95" />
+                  </Parameter>
+                  <Parameter id="anEjSFnrhESrFBGzlypSXg" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.12">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="21" source="Publication" description="Rodgers T, Leahy D, Rowland M. Physiologically based pharmacokinetic modeling 1: predicting the tissue distribution of moderate-to-strong bases. J Pharm Sci. 2005 Jun;94(6):1259-76. https://doi.org/10.1002/jps.20322" />
+                    <Info min="0" max="1" flag="122" seq="102" ref="0" bb="32" group="92" />
+                  </Parameter>
+                  <Parameter id="7Dhs9nFENkK2_BTyENAa_Q" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.13">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="102" ref="0" bb="32" group="95" />
+                  </Parameter>
+                  <Parameter id="DhTGt4NkkkaAAzeuKbfl1Q" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.521">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="22" source="Publication" description="Rodgers T, Rowland M. Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J Pharm Sci. 2006 Jun;95(6):1238-57 https://doi.org/10.1002/jps.20502" />
+                    <Info min="0" max="1" flag="122" seq="103" ref="0" bb="32" group="92" />
+                  </Parameter>
+                  <Parameter id="1isKPA_BT0aMXiid3jP-Iw" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.71">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="103" ref="0" bb="32" group="95" />
+                  </Parameter>
+                  <Parameter id="8I2qrO5gq02zPUESBA_Qcg" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.67">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
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+                    <Info min="0" max="1000" flag="122" seq="104" ref="0" bb="32" group="92" />
+                  </Parameter>
+                  <Parameter id="cue3y-IiM02JVadpxObr-g" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.00167">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="104" ref="0" bb="32" group="95" />
+                  </Parameter>
+                  <DistributedParameter id="k1c30xhfPEyyt3uID1lHXQ" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="scEHTBKHvkGAocCvOJlnvg" mode="Logical" isDefault="1" displayUnit="l">
+                    <Children>
+                      <Parameter id="VuP8_PbfJk2-n8MI-IgI8w" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.501571763654894">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="65" />
+                      </Parameter>
+                      <Parameter id="XIFrMLyeZ0O6ieudUuWyHA" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.19026527664" displayUnit="l">
+                        <Info min="0" flag="34" seq="1" ref="0" bb="32" group="65" />
+                      </Parameter>
+                      <Parameter id="ggY6JEut5kOgijmqJYTIEQ" name="Deviation" description="Standard deviation of Normal distribution" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.051153121992552" displayUnit="l">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="65" />
+                      </Parameter>
+                    </Children>
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
+                    <Info min="0" flag="106" seq="12" ref="0" bb="32" group="65" />
+                  </DistributedParameter>
+                  <DistributedParameter id="PdyJIGYKYku7EnDxSvberA" name="Specific blood flow rate" description="Blood flow rate normalized to the organ volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" formula="QeU1hwJTMU-E_vONpE8Shg" mode="Logical" isDefault="1" displayUnit="ml/min/100g organ">
+                    <Children>
+                      <Parameter id="RB5BViZ1y0C-J0Z57dh-oA" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
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+                        <Info min="0" flag="50" seq="1" ref="0" bb="32" group="5" />
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+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="5" />
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+                      <Tag value="Portal Vein Supplying Organ" />
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+                      <Container id="RbHVX1mOJ0uxXjVLGicQAw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
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+                          <Parameter id="TQQZWt6hy0uSl4Kde3Z-QQ" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_o63arufdk2PTQFsOiSkqg" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                          </Parameter>
+                          <Parameter id="gRbQD3wqKE-puIa9Yqmgeg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_B4r1Pf9BEa0ce4IJUo7mA" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                          </Parameter>
+                          <Parameter id="l3En-5EPCkipTL-3MeERHQ" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="3PTNCKfDA0yr8QD63uBncQ" isDefault="1" displayUnit="min">
+                            <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                        </Children>
+                      </Container>
+                    </Children>
+                  </Container>
+                </Children>
+              </Container>
+              <Container id="-SyMFuP2H0upzXXBCrRT9A" name="Skin" description="Skin" icon="Skin" mode="Logical" containerType="Organ">
+                <Tags>
+                  <Tag value="TissueOrgan" />
+                </Tags>
+                <Children>
+                  <Parameter id="n9SJNCiuAUyCrVTwnepCpA" name="Weight (tissue)" description="Weight of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="wccWBS9A2kuoeEsL1_z2ww" isDefault="1" displayUnit="kg">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
+                  </Parameter>
+                  <Parameter id="lCT_YbrLck69O2V3S6QBKA" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="_1qGrWaZQ0-mf9ujtwqKng" isDefault="1" displayUnit="l/min">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="23" ref="0" bb="32" group="27" />
+                  </Parameter>
+                  <Parameter id="g0gjLBpuj0yvg_faKgTB6A" name="Lymph flow rate" description="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="wo_Oqj188kKCGN911xCrEw" isDefault="1" displayUnit="l/min">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="23" ref="0" bb="32" group="58" />
+                  </Parameter>
+                  <Parameter id="rOfVqVTBZkqsGwCX7NKuvw" name="Volume (endothelium)" description="Volume of  vascular endothelium" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="PdPV-J4sGEOi4SLsy0pw0w" isDefault="1" displayUnit="l">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="62" seq="23" ref="0" bb="32" group="127" />
+                  </Parameter>
+                  <Parameter id="j5EnQMOGbk6ThH2Oq_QX-g" name="Fraction intracellular" description="Fraction of intracellular space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ZxHXV_JusU-NQSlrOekb3w" isDefault="1">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="62" seq="71" ref="0" bb="32" group="64" />
+                  </Parameter>
+                  <Parameter id="x4wME78DNkGLH7KxG9nQRA" name="Blood flow rate" description="Organ blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="kOPtX3xlRUyjlOOtEoP9Yg" isDefault="1" displayUnit="l/min">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="48" source="Other" description="Absolute value = specific value (i.e. value normalized to the volume of the organ) multiplied by the organ volume" />
+                    <Info min="0" flag="62" seq="202" ref="0" bb="32" group="5" />
+                  </Parameter>
+                  <Parameter id="ITer5bvfF0actcGmjAnZQQ" name="Density (tissue)" description="Density of tissue" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="38" seq="1" ref="0" bb="32" group="21" />
+                  </Parameter>
+                  <Parameter id="lAm0pOdk3EWUhWNCSi8gbA" name="Fluid recirculation flow proportionality factor" description="proportionality factor linking fluid recirculation flow to lymph flow via small pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.617">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="27" />
+                  </Parameter>
+                  <Parameter id="9kf4-QZMBUe10LgjEao22w" name="Lymph flow proportionality factor" description="Proportionality factor linking lymph flow to plasma flow" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.00352">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="58" />
+                  </Parameter>
+                  <Parameter id="CTdVrQ755EegY6lSxx9tMw" name="Organ volume mouse" description="Organ volume mouse" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0029" displayUnit="l">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="65" />
+                  </Parameter>
+                  <Parameter id="EradqnwykU-ny4E3inZRQw" name="Peripheral blood flow fraction" description="Blood flow fraction in organ used for calculation of peripheral venous blood concentrations" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.713">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="46" source="Publication" description="Thiel C, Schneckener S, Krauss M, Ghallab A, Hofmann U, et al. A systematic evaluation of the use of physiologically based pharmacokinetic modeling for cross-species extrapolation. J Pharm Sci. 2015 Jan;104(1):191-206 https://doi.org/10.1002/jps.24214" />
+                    <Info min="0" max="1" flag="122" seq="1" ref="0" bb="32" group="74" />
+                  </Parameter>
+                  <Parameter id="J-eCKwULuUeufkK6pCtZIA" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.6">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="1.6" max="1.6" flag="54" seq="1" ref="0" bb="32" group="2" />
+                  </Parameter>
+                  <Parameter id="lVfX1POKbUGcWQk0KusB4g" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="54" seq="1" ref="0" bb="32" group="94" />
+                  </Parameter>
+                  <Parameter id="KArXrqztNUK832wD34V6YA" name="Fraction vascular" description="Fraction of vascular space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.046">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="40" source="Publication" description="Edginton, A.N., Schmitt, W. &amp; Willmann, S. Clin Pharmacokinet (2006) 45: 1013. https://doi.org/10.2165/00003088-200645100-00005" />
+                    <Info min="0" max="1" flag="62" seq="10" ref="0" bb="32" group="64" />
+                  </Parameter>
+                  <Parameter id="9YhG0vXhCkWjs7QVSe-tOg" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.05">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" max="1" flag="122" seq="23" ref="0" bb="32" group="114" />
+                  </Parameter>
+                  <Parameter id="EWjjM9IBtUaAgxzyNT-dtA" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" icon="Parameter" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.94722E-11" displayUnit="ml/min/N">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="23" ref="0" bb="32" group="115" />
+                  </Parameter>
+                  <Parameter id="XOkcBYd9RUC6K4jb1-kssg" name="Radius (large pores)" description="Large endothelial pores radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.5E-07" displayUnit="µm">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="23" ref="0" bb="32" group="55" />
+                  </Parameter>
+                  <Parameter id="hJV--ODFDEy6WUHJLioyqg" name="Radius (small pores)" description="Small endothelial pores radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="4.5E-08" displayUnit="µm">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="23" ref="0" bb="32" group="99" />
+                  </Parameter>
+                  <Parameter id="s03AoroEtU29yJPpKND7bA" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.1">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
+                    <Info min="0" max="1" flag="122" seq="69" ref="0" bb="32" group="85" />
+                  </Parameter>
+                  <Parameter id="CiEeFYU0MkSt_Qv1UPy6CQ" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0284">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="69" ref="0" bb="32" group="86" />
+                  </Parameter>
+                  <Parameter id="wnT8ZdS5dUmXCXnD3AkSYA" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0111">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="70" ref="0" bb="32" group="86" />
+                  </Parameter>
+                  <Parameter id="hpY2tZoRuUO8Dnti29rXJA" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.288">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
+                    <Info min="0" max="1" flag="122" seq="70" ref="0" bb="32" group="85" />
+                  </Parameter>
+                  <Parameter id="YqnB033VfUi56tPLf21Vmg" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.277">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="22" source="Publication" description="Rodgers T, Rowland M. Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J Pharm Sci. 2006 Jun;95(6):1238-57 https://doi.org/10.1002/jps.20502" />
+                    <Info min="0" max="1" flag="122" seq="71" ref="0" bb="32" group="111" />
+                  </Parameter>
+                  <Parameter id="AJO8xyxd5EuDJweCbtp-1g" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="24" source="Publication" description="POULIN P, THEIL F. Prediction of Pharmacokinetics Prior to In Vivo Studies. 1. Mechanism-Based Prediction of Volume of Distribution. JOURNAL OF PHARMACEUTICAL SCIENCES, VOL. 91, NO. 1, JANUARY 2002" />
+                    <Info min="0" max="1" flag="122" seq="71" ref="0" bb="32" group="112" />
+                  </Parameter>
+                  <Parameter id="UqbMKrlQyk651su14jlAFA" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.096">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="22" source="Publication" description="Rodgers T, Rowland M. Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J Pharm Sci. 2006 Jun;95(6):1238-57 https://doi.org/10.1002/jps.20502" />
+                    <Info min="0" max="1" flag="122" seq="71" ref="0" bb="32" group="113" />
+                  </Parameter>
+                  <Parameter id="rbqVPPKAg0WS9psjDeFYdA" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.612">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
+                    <Info min="0" max="1" flag="122" seq="71" ref="0" bb="32" group="85" />
+                  </Parameter>
+                  <Parameter id="eDUuJX3Xw0GrHGim979WIQ" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.718">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="71" ref="0" bb="32" group="86" />
+                  </Parameter>
+                  <Parameter id="JltB-DVEuUWlWtTFqZEVVw" name="Fraction interstitial" description="Fraction of interstitial space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.302">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="19" source="Publication" description="Kawai R, Lemaire M, Steimer JL, Bruelisauer A, Niederberger W, Rowland M. Physiologically based pharmacokinetic study on a cyclosporin derivative, SDZ IMM 125. J Pharmacokinet Biopharm. 1994 Oct;22(5):327-65." />
+                    <Info min="0" max="1" flag="62" seq="72" ref="0" bb="32" group="64" />
+                  </Parameter>
+                  <Parameter id="bTbFysfGBUOXVfwEJdmX3w" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0603">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="22" source="Publication" description="Rodgers T, Rowland M. Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J Pharm Sci. 2006 Jun;95(6):1238-57 https://doi.org/10.1002/jps.20502" />
+                    <Info min="0" max="1" flag="122" seq="115" ref="0" bb="32" group="92" />
+                  </Parameter>
+                  <Parameter id="MyJRuBOEIkSPYh1p1EVUuw" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.126">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="115" ref="0" bb="32" group="95" />
+                  </Parameter>
+                  <Parameter id="_Bth3oiM8k6x6uopLgAgeA" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0044">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="22" source="Publication" description="Rodgers T, Rowland M. Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J Pharm Sci. 2006 Jun;95(6):1238-57 https://doi.org/10.1002/jps.20502" />
+                    <Info min="0" max="1" flag="122" seq="116" ref="0" bb="32" group="92" />
+                  </Parameter>
+                  <Parameter id="l3Tz2hH9hkKW4rko8S2ZwA" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0112">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="116" ref="0" bb="32" group="95" />
+                  </Parameter>
+                  <Parameter id="8Sw4HHvbD0uuxlN_f151FA" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.382">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="21" source="Publication" description="Rodgers T, Leahy D, Rowland M. Physiologically based pharmacokinetic modeling 1: predicting the tissue distribution of moderate-to-strong bases. J Pharm Sci. 2005 Jun;94(6):1259-76. https://doi.org/10.1002/jps.20322" />
+                    <Info min="0" max="1" flag="122" seq="117" ref="0" bb="32" group="92" />
+                  </Parameter>
+                  <Parameter id="b3uERDVjK0Or364YRyxXSA" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.41">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="117" ref="0" bb="32" group="95" />
+                  </Parameter>
+                  <Parameter id="iQEVDUdnhkKRIBugk7vurQ" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.276">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="22" source="Publication" description="Rodgers T, Rowland M. Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J Pharm Sci. 2006 Jun;95(6):1238-57 https://doi.org/10.1002/jps.20502" />
+                    <Info min="0" max="1" flag="122" seq="118" ref="0" bb="32" group="92" />
+                  </Parameter>
+                  <Parameter id="K__H_MfFNkys0ae6UHyf_w" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.47">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="118" ref="0" bb="32" group="95" />
+                  </Parameter>
+                  <Parameter id="DTS2mVSN2EyB1wxynrK-4A" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.32">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
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+                    <Info min="0" max="1000" flag="122" seq="119" ref="0" bb="32" group="92" />
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+                      <Tag value="TissueOrgan" />
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+                    <Children>
+                      <Parameter id="48tmDcuFZkW5kddEuI3yWA" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.50438901661299">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="65" />
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+                      <Parameter id="0XDaWgavek6nEPENPGMUVw" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="3.760912944" displayUnit="l">
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+                      </Parameter>
+                      <Parameter id="I2DJpt52BkCIc-OFNo4TrA" name="Deviation" description="Standard deviation of Normal distribution" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.1880456472" displayUnit="l">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="65" />
+                      </Parameter>
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+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
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+                      <Parameter id="LePc13BTMUuIeVrxvxy7pQ" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
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+                        <Info min="0" flag="50" seq="1" ref="0" bb="32" group="5" />
+                      </Parameter>
+                      <Parameter id="d_2TkXcSl0q8ikzZALFQFw" name="Deviation" description="Standard deviation of Normal distribution" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0043225" displayUnit="ml/min/100g organ">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="5" />
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+                    </Tags>
+                    <ValueOrigin id="40" source="Publication" description="Edginton, A.N., Schmitt, W. &amp; Willmann, S. Clin Pharmacokinet (2006) 45: 1013. https://doi.org/10.2165/00003088-200645100-00005" />
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+                      <Tag value="Skin" />
+                    </Tags>
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+                      <Parameter id="ajCJdhc6Lk6RYNW5iBfwYQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="jUuicTjwYECqpkpEHOcv6w" isDefault="1" displayUnit="l">
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+                          <Parameter id="UB3AaTOxtkOXhl2Opy-OrQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="pDRD-WocckCSQtVxG1Keug" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                          </Parameter>
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+                    <Tags>
+                      <Tag value="Skin" />
+                    </Tags>
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+                      <Parameter id="nx5rChShD06l2iSgFjZYNw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="jUuicTjwYECqpkpEHOcv6w" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
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+                        <Info min="0" flag="62" seq="23" ref="0" bb="2" group="121" />
+                      </Parameter>
+                      <Container id="J2_dpnZaN0ytXOc-GV27sQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
+                        <Children>
+                          <Parameter id="5DdazluN6UuczgZxza_T0g" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_o63arufdk2PTQFsOiSkqg" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
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+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                          </Parameter>
+                          <Parameter id="ors_FeCzJ02lcN1qcBAepA" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="3PTNCKfDA0yr8QD63uBncQ" isDefault="1" displayUnit="min">
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+                    <Tags>
+                      <Tag value="Skin" />
+                    </Tags>
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+                      <Parameter id="m093N3SMu0eUCu9W_DhAzA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="jUuicTjwYECqpkpEHOcv6w" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
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+                        <Info min="0" flag="62" seq="23" ref="0" bb="2" group="124" />
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+                        <Tags>
+                          <Tag value="Skin" />
+                        </Tags>
+                        <Info min="0" max="14" flag="122" seq="71" ref="0" bb="32" group="84" />
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+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                          </Parameter>
+                          <Parameter id="7mqHHybqnkWYeATNJJb2Yg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DHSuCiFnZEG81_Yw2ZVMmA" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
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+                          <Parameter id="Tf6uOr7SSUGXe_tR8HIHkA" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="3PTNCKfDA0yr8QD63uBncQ" isDefault="1" displayUnit="min">
+                            <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
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+                    <Tags>
+                      <Tag value="Skin" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="NAhiwhFStEmzIlnosu72uQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="-ijMbq55KEWxwtKNegWm3g" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
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+                      <Parameter id="3HjyL8ivpkKRDSibEfe2Vw" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="nGzrbq1s0U6FgEbhM3oFgQ" isDefault="1" displayUnit="l">
+                        <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                        <Info min="0" flag="62" seq="23" ref="0" bb="2" group="125" />
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+                      <Parameter id="oVsZI4omkEC-dwZw93549w" name="pH" description="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7">
+                        <Tags>
+                          <Tag value="Skin" />
+                        </Tags>
+                        <ValueOrigin id="34" source="Publication" description="Toxicol In Vitro. 2008 Mar;22(2):457-67 https://doi.org/10.1016/j.tiv.2007.09.010" />
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+                          <Parameter id="NJjYA0ttxEmt4Q7rZP37CQ" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_o63arufdk2PTQFsOiSkqg" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
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+                          <Parameter id="5GbV7OXud0WHUIBokb4R7w" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="dOg2ztqdmkqbKiIk-vtXjQ" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
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+                          <Parameter id="KGe6F_t65kehw3lPQBMPFA" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="3PTNCKfDA0yr8QD63uBncQ" isDefault="1" displayUnit="min">
+                            <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
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+              </Container>
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+                <Tags>
+                  <Tag value="Portal Vein Supplying Organ" />
+                  <Tag value="TissueOrgan" />
+                </Tags>
+                <Children>
+                  <Parameter id="vUqn2sbQKk-CKrGZtHHGcg" name="Weight (tissue)" description="Weight of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="wccWBS9A2kuoeEsL1_z2ww" isDefault="1" displayUnit="kg">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
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+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
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+                  <Parameter id="iqLrobpIXkKqK7R2YpJRXQ" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="_1qGrWaZQ0-mf9ujtwqKng" isDefault="1" displayUnit="l/min">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
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+                    <Info min="0" flag="122" seq="24" ref="0" bb="32" group="27" />
+                  </Parameter>
+                  <Parameter id="VeSKrl76JUK5dZt4dWdB0Q" name="Lymph flow rate" description="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="wo_Oqj188kKCGN911xCrEw" isDefault="1" displayUnit="l/min">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
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+                    <Info min="0" flag="122" seq="24" ref="0" bb="32" group="58" />
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+                  <Parameter id="pou68FoZskKqV-044wm6QA" name="Volume (endothelium)" description="Volume of  vascular endothelium" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="bCzb6aG-60GOqnpBmjVKHg" isDefault="1" displayUnit="l">
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+                    <Info min="0" flag="62" seq="24" ref="0" bb="32" group="127" />
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+                  <Parameter id="l8tKaBpnrEqaAJo_L-e-WQ" name="Fraction intracellular" description="Fraction of intracellular space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ZxHXV_JusU-NQSlrOekb3w" isDefault="1">
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+                      <Tag value="Portal Vein Supplying Organ" />
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+                    <Info min="0" max="1" flag="62" seq="74" ref="0" bb="32" group="64" />
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+                  <Parameter id="jtMwZv4lx02SMsZL-zqfEA" name="Blood flow rate" description="Organ blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="kOPtX3xlRUyjlOOtEoP9Yg" isDefault="1" displayUnit="l/min">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
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+                    <ValueOrigin id="48" source="Other" description="Absolute value = specific value (i.e. value normalized to the volume of the organ) multiplied by the organ volume" />
+                    <Info min="0" flag="62" seq="242" ref="0" bb="32" group="5" />
+                  </Parameter>
+                  <Parameter id="KGKW_0Id5U6hUJuZi5BSVg" name="Density (tissue)" description="Density of tissue" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
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+                    <Info min="0" flag="38" seq="1" ref="0" bb="32" group="21" />
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+                  <Parameter id="7B3ae2GRDUWv4O-y0jPyQw" name="Fluid recirculation flow proportionality factor" description="proportionality factor linking fluid recirculation flow to lymph flow via small pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.01">
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+                      <Tag value="Portal Vein Supplying Organ" />
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+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="27" />
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+                  <Parameter id="VcSa2imgL0Sf6e0dhgrW3Q" name="Lymph flow proportionality factor" description="Proportionality factor linking lymph flow to plasma flow" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0199">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
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+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="58" />
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+                  <Parameter id="sO808VXDxE6vhtO_QWEXBg" name="Organ volume mouse" description="Organ volume mouse" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0001" displayUnit="l">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
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+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="65" />
+                  </Parameter>
+                  <Parameter id="bLFWnmoaeUiyyuzHpStxfA" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.75">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0.75" max="0.75" flag="54" seq="1" ref="0" bb="32" group="2" />
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+                    <Info min="0" max="1" flag="122" seq="74" ref="0" bb="32" group="86" />
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+                    <ValueOrigin id="19" source="Publication" description="Kawai R, Lemaire M, Steimer JL, Bruelisauer A, Niederberger W, Rowland M. Physiologically based pharmacokinetic study on a cyclosporin derivative, SDZ IMM 125. J Pharmacokinet Biopharm. 1994 Oct;22(5):327-65." />
+                    <Info min="0" max="1" flag="62" seq="75" ref="0" bb="32" group="64" />
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+                    <Info min="0" max="1" flag="122" seq="122" ref="0" bb="32" group="92" />
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+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="5" />
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+                        <Info min="0" flag="50" seq="1" ref="0" bb="32" group="5" />
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+                      <Parameter id="mn8w4sIKfU6XKBEBo4rVMg" name="Deviation" description="Standard deviation of Normal distribution" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.04005625" displayUnit="ml/min/100g organ">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="5" />
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+                      <Parameter id="urg3JZNXT0e69xCIvD2hvw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="jUuicTjwYECqpkpEHOcv6w" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
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+                      <Parameter id="H5aXOWarfUiJaPN8CGdKBw" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="2ErPZJcYvUyL3QogRRKmZg" isDefault="1" displayUnit="l">
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+                        <Info min="0" flag="62" seq="24" ref="0" bb="2" group="126" />
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+                      <Container id="FKe-eMRa002BGiQ9mae9lw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
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+                          <Parameter id="dxtS8tp85kmmHZwh_XfU2A" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="pDRD-WocckCSQtVxG1Keug" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                          </Parameter>
+                          <Parameter id="O8spqyt9dEWULMdnzAy3WQ" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="3PTNCKfDA0yr8QD63uBncQ" isDefault="1" displayUnit="min">
+                            <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                        </Children>
+                      </Container>
+                    </Children>
+                  </Container>
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+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="Spleen" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="zl_vHZBL0keER7c9WavUrA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="jUuicTjwYECqpkpEHOcv6w" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="xxLIaBe6wk-ZPoYtX48GuA" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="V2_FdO3puUGekuCdqn4lGg" isDefault="1" displayUnit="l">
+                        <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                        <Info min="0" flag="62" seq="24" ref="0" bb="2" group="121" />
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+                      <Container id="wyOWgDo900-Xj5M5w3EFNg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
+                        <Children>
+                          <Parameter id="iqEEzdFSm06picYQjlIQXg" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_o63arufdk2PTQFsOiSkqg" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                          </Parameter>
+                          <Parameter id="fBOtcjdzcU-hu5EF-VnvfA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_B4r1Pf9BEa0ce4IJUo7mA" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                          </Parameter>
+                          <Parameter id="SgOJIMJoqE2Sb7c4iaRC2Q" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="3PTNCKfDA0yr8QD63uBncQ" isDefault="1" displayUnit="min">
+                            <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
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+                    </Children>
+                  </Container>
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+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="Spleen" />
+                    </Tags>
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+                      <Parameter id="YcM3d98OwEWyOm0HFaKcSQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="jUuicTjwYECqpkpEHOcv6w" isDefault="1" displayUnit="l">
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+                      <Container id="-ya3_ZYFC0GqNSySeJL-_w" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
+                        <Children>
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+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
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+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                          </Parameter>
+                          <Parameter id="MdIpi4LGcES-TEsDo-RYdw" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="3PTNCKfDA0yr8QD63uBncQ" isDefault="1" displayUnit="min">
+                            <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                        </Children>
+                      </Container>
+                    </Children>
+                  </Container>
+                  <Container id="i1qACGojb0OWgiB4FLoxfQ" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="Spleen" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="43xN_eD2tkutfmgv72tSOA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="-ijMbq55KEWxwtKNegWm3g" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="Z2i_fqK8Zky-csEuYN-rAg" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="nGzrbq1s0U6FgEbhM3oFgQ" isDefault="1" displayUnit="l">
+                        <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                        <Info min="0" flag="62" seq="24" ref="0" bb="2" group="125" />
+                      </Parameter>
+                      <Parameter id="hJRxeiFUVE6_DJF558p2Nw" name="pH" description="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7">
+                        <Tags>
+                          <Tag value="Portal Vein Supplying Organ" />
+                          <Tag value="Spleen" />
+                        </Tags>
+                        <ValueOrigin id="34" source="Publication" description="Toxicol In Vitro. 2008 Mar;22(2):457-67 https://doi.org/10.1016/j.tiv.2007.09.010" />
+                        <Info min="0" max="14" flag="122" seq="74" ref="0" bb="32" group="83" />
+                      </Parameter>
+                      <Container id="OFD9pgorkE6sSDqxwW8kMg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Molecule">
+                        <Children>
+                          <Parameter id="MqsoabRBUEebhb39igIp8A" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_o63arufdk2PTQFsOiSkqg" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                          </Parameter>
+                          <Parameter id="cUd_FgWa3EqERpiJAB0gZA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Z_J_Z1DtCEKTOu5UKTjnDA" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                          </Parameter>
+                          <Parameter id="-mobJ-L6kkmidt4BWLmhjg" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="3PTNCKfDA0yr8QD63uBncQ" isDefault="1" displayUnit="min">
+                            <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
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+              <Container id="A5VY0tNQckqHmkgT3kafKw" name="Saliva" description="Saliva" icon="Saliva" mode="Logical" containerType="Organ">
+                <Children>
+                  <Parameter id="GCvew4gpEUKccJYCP0LYFw" name="Weight (tissue)" description="Weight of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="wccWBS9A2kuoeEsL1_z2ww" isDefault="1" displayUnit="kg">
+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
+                  </Parameter>
+                  <Parameter id="941ClgYk8kKkTMxqQcJOmQ" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="AQdOk3vYeESnjaGIiK2RSQ" isDefault="1" displayUnit="l">
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+                    <Info min="0" flag="122" seq="14" ref="0" bb="32" group="65" />
+                  </Parameter>
+                  <Parameter id="ThHIRfuoqkiK_HgOjBqUzA" name="Density (tissue)" description="Density of tissue" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
+                    <Info min="0" flag="38" seq="1" ref="0" bb="32" group="21" />
+                  </Parameter>
+                  <Parameter id="Lzz-HeedwEK2eOqoXldbLg" name="Saliva flow rate" description="Saliva flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.001" displayUnit="l/min">
+                    <ValueOrigin id="43" source="Internet" description="Willi Cawello. Pharmacokinetics and bioavailability derived from various body fluids. http://www.agah.eu/fileadmin/_migrated/content_uploads/W._Cawello__2__25.05.07.pdf" />
+                    <Info min="0.0001" max="0.01" flag="122" seq="1" ref="0" bb="32" group="93" />
+                  </Parameter>
+                  <Container id="tn0uSAa4EEmp4WYEGGvtIw" name="Saliva" description="Saliva" icon="Saliva" mode="Physical" containerType="Compartment">
+                    <Tags>
+                      <Tag value="Saliva" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="3ip3YRTgokahR0-jZBF6Lw" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="UWxwleFSdECDymhLy2WmBQ" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="54" seq="666" ref="0" bb="2" group="65" />
+                      </Parameter>
+                      <Parameter id="19Sjg-nLd0GJEt0SR7KXAw" name="pH (saliva)" description="pH of saliva" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.4">
+                        <Tags>
+                          <Tag value="Saliva" />
+                        </Tags>
+                        <ValueOrigin id="43" source="Internet" description="Willi Cawello. Pharmacokinetics and bioavailability derived from various body fluids. http://www.agah.eu/fileadmin/_migrated/content_uploads/W._Cawello__2__25.05.07.pdf" />
+                        <Info min="0" max="14" flag="122" seq="1" ref="0" bb="32" group="82" />
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+                    <Tags>
+                      <Tag value="Saliva" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="aKMQULDMtUSh2EuVVJ8klw" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="UWxwleFSdECDymhLy2WmBQ" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="54" seq="666" ref="0" bb="2" group="65" />
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+              <Tags>
+                <Tag value="Neighborhood: BloodCells / BloodCells" />
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+              <Tags>
+                <Tag value="Neighborhood: Plasma / Plasma" />
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+              <Tags>
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+                <Container id="T5wDzKAm8k27jlbGerSvog" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+                <Parameter id="BViTxKS81E-rRXgHn5UJyg" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="MBpwdXYbNUiqS3uQZDhduw" isDefault="1" displayUnit="cm²">
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+                <Parameter id="UKH42ekgB0eYNSaXhn_oZA" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="MBpwdXYbNUiqS3uQZDhduw" isDefault="1" displayUnit="cm²">
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+              <Tags>
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+                    <Parameter id="fDkGfsIFlkekWIYvCQOIdg" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="pn4TOZacr0GWHd9xAwFj8g" isDefault="1" displayUnit="cm/min">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="78" />
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+                    <Parameter id="8W7YkiQduEG4-Kc8Pq3SZw" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="QkTJVxVP3Ee97Zuh3Lg62w" isDefault="1" displayUnit="cm/min">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="76" />
+                    </Parameter>
+                    <Parameter id="9tugN7X_u0u6uml81H-Ucw" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="SZrmcd1JDEW6MIjlHsCCew" isDefault="1" displayUnit="l/min">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="n0lXkGIkf06vgBCfrWUPQA" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="y659fcMlZEKHrLpFwmHmIw" isDefault="1" displayUnit="l/min">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="G2MWowAidUajhN_TP5JeVg" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="UgZ8q0MWoUqtJhxPStVohw" isDefault="1">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="0PLfuBhDzU2_j3EeEupMdQ" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="UgZ8q0MWoUqtJhxPStVohw" isDefault="1">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="-eCYsVXTCkimJC-TZ5u4-w" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="LFxvD31Yj0GGjFItDGX_mg" isDefault="1">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="69" />
+                    </Parameter>
+                    <Parameter id="TH0SNlZiy0yHfZ218fUcPA" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="AGiWTt8CvEmeuesoKmPNgw" isDefault="1">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+                    </Parameter>
+                  </Children>
+                </Container>
+                <Parameter id="9CNwBKw6b0msrAbLvMwT8g" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="xEuPIYqLIk2lKuyHeKmz_w" isDefault="1" displayUnit="cm²">
+                  <Tags>
+                    <Tag value="Neighborhood: Interstitial / Intracellular" />
+                  </Tags>
+                  <Info min="0" flag="122" seq="1" ref="0" bb="32" group="105" />
+                </Parameter>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="kUZZ072tXkmtBjg2vqQUxg" name="Bone_pls_Bone_bc" description="Neighborhood between Bone/Plasma and Bone/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="GOuaccg6akC1RvBP5q6UXA" secondNeighbor="wRGMBojr30ywQhW67eF8qw">
+              <Tags>
+                <Tag value="Neighborhood: Plasma / BloodCells" />
+              </Tags>
+              <Children>
+                <Container id="dpoNTz4Ep0-1l2_c3WZOKw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+                <Parameter id="Pbw4k4E_HkSf7cHO4OksPQ" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="xH6OXEC65ESnPJ2unASWQA" isDefault="1" displayUnit="cm²">
+                  <Tags>
+                    <Tag value="Neighborhood: Plasma / BloodCells" />
+                  </Tags>
+                  <Info min="0" flag="122" seq="3" ref="0" bb="32" group="104" />
+                </Parameter>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="pHVdvM0LGk2FJuFlkZZpVQ" name="Bone_pls_Bone_int" description="Neighborhood between Bone/Plasma and Bone/Interstitial" mode="Logical" containerType="Neighborhood" firstNeighbor="GOuaccg6akC1RvBP5q6UXA" secondNeighbor="YoF-WLk2CkSpyTLDur7R8g">
+              <Tags>
+                <Tag value="Neighborhood: Plasma / Interstitial" />
+              </Tags>
+              <Children>
+                <Container id="QuuGeiplfUyuNi8nmA0kqg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="4ysDIZKUFUmzqJICaB2fsA" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
+                      <ValueOrigin id="49" source="Other" method="Assumption" description="Assumption: very fast exchange" />
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="77" />
+                    </Parameter>
+                    <Parameter id="1p59xtqNvkCeZYnWPls_8w" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="iKUspopJzEClLaOxGRLgvw" isDefault="1">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="70" />
+                    </Parameter>
+                  </Children>
+                </Container>
+                <Parameter id="RJ1VuDp9DUuSJUrLLD7Xbg" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="YX57qmODbU-M9-4csS_AyA" isDefault="1" displayUnit="cm²">
+                  <Tags>
+                    <Tag value="Neighborhood: Plasma / Interstitial" />
+                  </Tags>
+                  <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                  <Info min="0" flag="122" seq="1" ref="0" bb="32" group="106" />
+                </Parameter>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="U8W-HyI_U0O_W2lojzOAkw" name="Bone_pls_VenousBlood_pls" description="Neighborhood between Bone/Plasma and Venous Blood/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="GOuaccg6akC1RvBP5q6UXA" secondNeighbor="OW9eeGpb1Ui7R75zcOETVQ">
+              <Tags>
+                <Tag value="Neighborhood: Plasma / Plasma" />
+              </Tags>
+              <Children>
+                <Container id="uEfmkWGkQ0GAZByeTX-L8A" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="UhMjNrdE_kSPF3cGI2KfIA" name="Brain_bc_VenousBlood_bc" description="Neighborhood between Brain/Blood Cells and Venous Blood/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="bN3VXHsGO0OXJk_ZKrzMRA" secondNeighbor="Psihdre1OUqL7biUDEcQDw">
+              <Tags>
+                <Tag value="Neighborhood: BloodCells / BloodCells" />
+              </Tags>
+              <Children>
+                <Container id="u1trrXKb-UqXSRwO8Qd34g" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="9mee7SMOgUO32aubLtwe3A" name="Brain_int_Brain_cell" description="Neighborhood between Brain/Interstitial and Brain/Intracellular" mode="Logical" containerType="Neighborhood" firstNeighbor="hNqEEM7hGUynXaLr_g4p3A" secondNeighbor="ghU-3KHXG0qFUU_DuZrhUg">
+              <Tags>
+                <Tag value="Neighborhood: Interstitial / Intracellular" />
+              </Tags>
+              <Children>
+                <Container id="updsc_zmH0OrHgYPPWaCnw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="BLn-HKpejUewWbAjTyANjw" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="pn4TOZacr0GWHd9xAwFj8g" isDefault="1" displayUnit="cm/min">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="78" />
+                    </Parameter>
+                    <Parameter id="nTJMr8gKk02APohifsMenQ" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="QkTJVxVP3Ee97Zuh3Lg62w" isDefault="1" displayUnit="cm/min">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="76" />
+                    </Parameter>
+                    <Parameter id="ywUAlWC7u0ma1tEcAPHJLg" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="SZrmcd1JDEW6MIjlHsCCew" isDefault="1" displayUnit="l/min">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="l2fZCufYsEGExFHChACIbQ" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="y659fcMlZEKHrLpFwmHmIw" isDefault="1" displayUnit="l/min">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="jlAPvz_lKkCXlSOmr6zYUg" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="UgZ8q0MWoUqtJhxPStVohw" isDefault="1">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="tI_ZsH7yvECfh0eL7iJxUQ" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="UgZ8q0MWoUqtJhxPStVohw" isDefault="1">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="S641c20kJEaTelZR4jWc9A" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="LFxvD31Yj0GGjFItDGX_mg" isDefault="1">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="69" />
+                    </Parameter>
+                    <Parameter id="3zt3F4cUJEiO0Qodg46dsg" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="AGiWTt8CvEmeuesoKmPNgw" isDefault="1">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+                    </Parameter>
+                  </Children>
+                </Container>
+                <Parameter id="Zr_uIug3hU6Ed0kROScn4A" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="yXJJyWUUEUOJSSViPlaHNw" isDefault="1" displayUnit="cm²">
+                  <Tags>
+                    <Tag value="Neighborhood: Interstitial / Intracellular" />
+                  </Tags>
+                  <Info min="0" flag="122" seq="2" ref="0" bb="32" group="105" />
+                </Parameter>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="BN0JqXTUBkiwseaeVAVQow" name="Brain_pls_Brain_bc" description="Neighborhood between Brain/Plasma and Brain/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="7DNB5PpQXESK4u6Vgt7P3w" secondNeighbor="bN3VXHsGO0OXJk_ZKrzMRA">
+              <Tags>
+                <Tag value="Neighborhood: Plasma / BloodCells" />
+              </Tags>
+              <Children>
+                <Container id="GQmHYsOS30WjuERnLJvZRA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+                <Parameter id="mg5JDkJszEiAxBg0wZcYSw" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="xH6OXEC65ESnPJ2unASWQA" isDefault="1" displayUnit="cm²">
+                  <Tags>
+                    <Tag value="Neighborhood: Plasma / BloodCells" />
+                  </Tags>
+                  <Info min="0" flag="122" seq="4" ref="0" bb="32" group="104" />
+                </Parameter>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="SGFZ8jqiw0GNiqNoazX9Kg" name="Brain_pls_Brain_int" description="Neighborhood between Brain/Plasma and Brain/Interstitial" mode="Logical" containerType="Neighborhood" firstNeighbor="7DNB5PpQXESK4u6Vgt7P3w" secondNeighbor="hNqEEM7hGUynXaLr_g4p3A">
+              <Tags>
+                <Tag value="Neighborhood: Plasma / Interstitial" />
+              </Tags>
+              <Children>
+                <Container id="d_ARMhpCtUGeTIkz7mLXow" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="nnAUEhnUY0S3iz1U9o1G7A" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="RvyzeQxsbku3OjJ_WfADbg" isDefault="1" displayUnit="cm/min">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="77" />
+                    </Parameter>
+                    <Parameter id="yQAPBmCtQUKcbbbln-UcMw" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="iKUspopJzEClLaOxGRLgvw" isDefault="1">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="70" />
+                    </Parameter>
+                  </Children>
+                </Container>
+                <Parameter id="Ie94rUFoF02WVszNKOyePw" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="YX57qmODbU-M9-4csS_AyA" isDefault="1" displayUnit="cm²">
+                  <Tags>
+                    <Tag value="Neighborhood: Plasma / Interstitial" />
+                  </Tags>
+                  <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                  <Info min="0" flag="122" seq="2" ref="0" bb="32" group="106" />
+                </Parameter>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="4t_kCXbc6UWacVCdrw_KGA" name="Brain_pls_VenousBlood_pls" description="Neighborhood between Brain/Plasma and Venous Blood/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="7DNB5PpQXESK4u6Vgt7P3w" secondNeighbor="OW9eeGpb1Ui7R75zcOETVQ">
+              <Tags>
+                <Tag value="Neighborhood: Plasma / Plasma" />
+              </Tags>
+              <Children>
+                <Container id="mHur1uMoaki3nNuAYYK3zg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="n7H707rR0ESgUE3DCNGcAA" name="Fat_bc_VenousBlood_bc" description="Neighborhood between Fat/Blood Cells and Venous Blood/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="y-Nrpm_4AEGF3WJNdy4pUQ" secondNeighbor="Psihdre1OUqL7biUDEcQDw">
+              <Tags>
+                <Tag value="Neighborhood: BloodCells / BloodCells" />
+              </Tags>
+              <Children>
+                <Container id="lFNjTHHk60WMEKXbiIzACg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="23mGDm0WQ0ChifQukEzfng" name="Fat_int_Fat_cell" description="Neighborhood between Fat/Interstitial and Fat/Intracellular" mode="Logical" containerType="Neighborhood" firstNeighbor="zk4tg5SnG0WzJcOnfvt3_Q" secondNeighbor="Ir0opX_oJUK91yMOaPMmSQ">
+              <Tags>
+                <Tag value="Neighborhood: Interstitial / Intracellular" />
+              </Tags>
+              <Children>
+                <Container id="NxlnqW6vq0249n2DBm7rog" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="_Z2DepLBxkixU7zCy5YJtQ" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="pn4TOZacr0GWHd9xAwFj8g" isDefault="1" displayUnit="cm/min">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="78" />
+                    </Parameter>
+                    <Parameter id="aOKSOHjLNE6sIweA6fQd2A" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="QkTJVxVP3Ee97Zuh3Lg62w" isDefault="1" displayUnit="cm/min">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="76" />
+                    </Parameter>
+                    <Parameter id="Hg1bkGqrX0GmPL1dkZh2vQ" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="SZrmcd1JDEW6MIjlHsCCew" isDefault="1" displayUnit="l/min">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="Pe3i9lFq7UeG7HwcEo5oxA" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="y659fcMlZEKHrLpFwmHmIw" isDefault="1" displayUnit="l/min">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="Z4IXliEAskKVNpW0Wy0iCA" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="UgZ8q0MWoUqtJhxPStVohw" isDefault="1">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="apl_2biDokSEcx4uY5i6Wg" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="UgZ8q0MWoUqtJhxPStVohw" isDefault="1">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="xHuIYntDI0yYugd7fCRXww" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="LFxvD31Yj0GGjFItDGX_mg" isDefault="1">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="69" />
+                    </Parameter>
+                    <Parameter id="Imb430bB80uOvyJxcIenVw" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="AGiWTt8CvEmeuesoKmPNgw" isDefault="1">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+                    </Parameter>
+                  </Children>
+                </Container>
+                <Parameter id="MBbOXlIhQEq5Awxg130yNw" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="WTz46GvVGk-Je33to6e9ww" isDefault="1" displayUnit="cm²">
+                  <Tags>
+                    <Tag value="Neighborhood: Interstitial / Intracellular" />
+                  </Tags>
+                  <Info min="0" flag="122" seq="3" ref="0" bb="32" group="105" />
+                </Parameter>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="HCS2b8r670Wn62t9NeDTFA" name="Fat_pls_Fat_bc" description="Neighborhood between Fat/Plasma and Fat/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="hrh6Bbq1yECrUjUyce8Xvg" secondNeighbor="y-Nrpm_4AEGF3WJNdy4pUQ">
+              <Tags>
+                <Tag value="Neighborhood: Plasma / BloodCells" />
+              </Tags>
+              <Children>
+                <Container id="sxt8iawr6EizCVy0yWLguA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+                <Parameter id="P-_JNx2abEOHRphRF3dCSw" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="xH6OXEC65ESnPJ2unASWQA" isDefault="1" displayUnit="cm²">
+                  <Tags>
+                    <Tag value="Neighborhood: Plasma / BloodCells" />
+                  </Tags>
+                  <Info min="0" flag="122" seq="5" ref="0" bb="32" group="104" />
+                </Parameter>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="xibRGHTdbkCHwMWmHrlVxg" name="Fat_pls_Fat_int" description="Neighborhood between Fat/Plasma and Fat/Interstitial" mode="Logical" containerType="Neighborhood" firstNeighbor="hrh6Bbq1yECrUjUyce8Xvg" secondNeighbor="zk4tg5SnG0WzJcOnfvt3_Q">
+              <Tags>
+                <Tag value="Neighborhood: Plasma / Interstitial" />
+              </Tags>
+              <Children>
+                <Container id="J7hdlppQXkOeuPHiD-oHoA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="AGfvR_Dr6Uqz-zCSg7DqSA" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
+                      <ValueOrigin id="49" source="Other" method="Assumption" description="Assumption: very fast exchange" />
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="77" />
+                    </Parameter>
+                    <Parameter id="B2IgpFxLk0mkHezBsrwDZw" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="iKUspopJzEClLaOxGRLgvw" isDefault="1">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="70" />
+                    </Parameter>
+                  </Children>
+                </Container>
+                <Parameter id="vpuKQvecmEWTv8g6P0cZ0Q" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="YX57qmODbU-M9-4csS_AyA" isDefault="1" displayUnit="cm²">
+                  <Tags>
+                    <Tag value="Neighborhood: Plasma / Interstitial" />
+                  </Tags>
+                  <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                  <Info min="0" flag="122" seq="3" ref="0" bb="32" group="106" />
+                </Parameter>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="fvAbFeqaxkylydr5hvKupA" name="Fat_pls_VenousBlood_pls" description="Neighborhood between Fat/Plasma and Venous Blood/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="hrh6Bbq1yECrUjUyce8Xvg" secondNeighbor="OW9eeGpb1Ui7R75zcOETVQ">
+              <Tags>
+                <Tag value="Neighborhood: Plasma / Plasma" />
+              </Tags>
+              <Children>
+                <Container id="wmwUlFBzVUu029gYwuwMFg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="9ZPqzqJhI0qjMvGnlA2bWA" name="Gonads_bc_VenousBlood_bc" description="Neighborhood between Gonads/Blood Cells and Venous Blood/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="PDxTJKGF10G81bGQzM6xCA" secondNeighbor="Psihdre1OUqL7biUDEcQDw">
+              <Tags>
+                <Tag value="Neighborhood: BloodCells / BloodCells" />
+              </Tags>
+              <Children>
+                <Container id="4G0un0yXo06MzD9XJml4tQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="VxC0_ywKsk6EaDxhgSIRSQ" name="Gonads_int_Gonads_cell" description="Neighborhood between Gonads/Interstitial and Gonads/Intracellular" mode="Logical" containerType="Neighborhood" firstNeighbor="1LmvpJQ9KkmJ_aDJzspkcg" secondNeighbor="4LStjMi3mUabzS2qaRoDIA">
+              <Tags>
+                <Tag value="Neighborhood: Interstitial / Intracellular" />
+              </Tags>
+              <Children>
+                <Container id="FAaj1YapAEq48GASKx1XWA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="dkDENiHTWEWnW3wErRuSRQ" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="pn4TOZacr0GWHd9xAwFj8g" isDefault="1" displayUnit="cm/min">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="78" />
+                    </Parameter>
+                    <Parameter id="_GL_6XwkrUuqJim3twDWzw" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="QkTJVxVP3Ee97Zuh3Lg62w" isDefault="1" displayUnit="cm/min">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="76" />
+                    </Parameter>
+                    <Parameter id="XAww5DQofUOjBigvDtXPpg" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="SZrmcd1JDEW6MIjlHsCCew" isDefault="1" displayUnit="l/min">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="2I7N6_gF9Ui0_3kn8FJSoA" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="y659fcMlZEKHrLpFwmHmIw" isDefault="1" displayUnit="l/min">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="BM_OTws6vUqjMk4mAPx-pw" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="UgZ8q0MWoUqtJhxPStVohw" isDefault="1">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="wGH_EwjmqUKRDaSZTPrwAw" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="UgZ8q0MWoUqtJhxPStVohw" isDefault="1">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="R7S8T9DC8kqgSRf8ZubhQg" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="LFxvD31Yj0GGjFItDGX_mg" isDefault="1">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="69" />
+                    </Parameter>
+                    <Parameter id="0SV00qlGaEaFwJz_rlN6aQ" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="AGiWTt8CvEmeuesoKmPNgw" isDefault="1">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+                    </Parameter>
+                  </Children>
+                </Container>
+                <Parameter id="aUDgTvbANUC58MvVrn1XKQ" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="kntRcDHEqUygxc6M3EBKNA" isDefault="1" displayUnit="cm²">
+                  <Tags>
+                    <Tag value="Neighborhood: Interstitial / Intracellular" />
+                  </Tags>
+                  <Info min="0" flag="122" seq="4" ref="0" bb="32" group="105" />
+                </Parameter>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="ihgNxsycA0i45p8jPwW-uw" name="Gonads_pls_Gonads_bc" description="Neighborhood between Gonads/Plasma and Gonads/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="yPB5n3md30-4KI9XTzIWaA" secondNeighbor="PDxTJKGF10G81bGQzM6xCA">
+              <Tags>
+                <Tag value="Neighborhood: Plasma / BloodCells" />
+              </Tags>
+              <Children>
+                <Container id="4I9BIdzVe0K4AEM6xCEQww" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+                <Parameter id="fYBtJQBCq0Geuzovt8DkXQ" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="xH6OXEC65ESnPJ2unASWQA" isDefault="1" displayUnit="cm²">
+                  <Tags>
+                    <Tag value="Neighborhood: Plasma / BloodCells" />
+                  </Tags>
+                  <Info min="0" flag="122" seq="6" ref="0" bb="32" group="104" />
+                </Parameter>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="0mZnR69PIka_B4yOmIJOTA" name="Gonads_pls_Gonads_int" description="Neighborhood between Gonads/Plasma and Gonads/Interstitial" mode="Logical" containerType="Neighborhood" firstNeighbor="yPB5n3md30-4KI9XTzIWaA" secondNeighbor="1LmvpJQ9KkmJ_aDJzspkcg">
+              <Tags>
+                <Tag value="Neighborhood: Plasma / Interstitial" />
+              </Tags>
+              <Children>
+                <Container id="zzEIascRUkq5z6Wrz0xllA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="soMSxHlJtEaCMEMHD--itQ" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
+                      <ValueOrigin id="49" source="Other" method="Assumption" description="Assumption: very fast exchange" />
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="77" />
+                    </Parameter>
+                    <Parameter id="bcRTZT8jmE-gTtUtjo4bWw" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="iKUspopJzEClLaOxGRLgvw" isDefault="1">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="70" />
+                    </Parameter>
+                  </Children>
+                </Container>
+                <Parameter id="aqEtVgxDgUCgwPW_qoUjAQ" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="YX57qmODbU-M9-4csS_AyA" isDefault="1" displayUnit="cm²">
+                  <Tags>
+                    <Tag value="Neighborhood: Plasma / Interstitial" />
+                  </Tags>
+                  <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                  <Info min="0" flag="122" seq="4" ref="0" bb="32" group="106" />
+                </Parameter>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="9wYUbuQEEUW__Y1wgr4ZCA" name="Gonads_pls_VenousBlood_pls" description="Neighborhood between Gonads/Plasma and Venous Blood/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="yPB5n3md30-4KI9XTzIWaA" secondNeighbor="OW9eeGpb1Ui7R75zcOETVQ">
+              <Tags>
+                <Tag value="Neighborhood: Plasma / Plasma" />
+              </Tags>
+              <Children>
+                <Container id="HSrmFR3PiUOaK7Nr-nb6ng" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="4mqLM62m_0qLHFxs3pr4Sw" name="Heart_bc_VenousBlood_bc" description="Neighborhood between Heart/Blood Cells and Venous Blood/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="XGjCqmNgsEiMW9ot69l81A" secondNeighbor="Psihdre1OUqL7biUDEcQDw">
+              <Tags>
+                <Tag value="Neighborhood: BloodCells / BloodCells" />
+              </Tags>
+              <Children>
+                <Container id="I4slaNF-_Ee-CS-VY0uegw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="NgFd6Xf7A0GgxLMdQu5nZw" name="Heart_int_Heart_cell" description="Neighborhood between Heart/Interstitial and Heart/Intracellular" mode="Logical" containerType="Neighborhood" firstNeighbor="1J0PG5NZq06wlO8fgAT1TQ" secondNeighbor="w76-1ar03UKTtqfryYI_Sg">
+              <Tags>
+                <Tag value="Neighborhood: Interstitial / Intracellular" />
+              </Tags>
+              <Children>
+                <Container id="wiNcAeQLmEyilCm1Mf-lhQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="C_fNXGMa2EG0C8jIO3zueQ" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="pn4TOZacr0GWHd9xAwFj8g" isDefault="1" displayUnit="cm/min">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="78" />
+                    </Parameter>
+                    <Parameter id="nDs7DhKV20y9vsXa9aGGgg" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="QkTJVxVP3Ee97Zuh3Lg62w" isDefault="1" displayUnit="cm/min">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="76" />
+                    </Parameter>
+                    <Parameter id="Y4Gq4miPO0SgM4ulff2uXw" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="SZrmcd1JDEW6MIjlHsCCew" isDefault="1" displayUnit="l/min">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="-jCv5U2J9ki4daAaIYqXNg" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="y659fcMlZEKHrLpFwmHmIw" isDefault="1" displayUnit="l/min">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="yV3qQNBUV0-eqt8AS3RU7Q" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="UgZ8q0MWoUqtJhxPStVohw" isDefault="1">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="lMXlYyEBoEGPWjtUSagoLA" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="UgZ8q0MWoUqtJhxPStVohw" isDefault="1">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="XQrYsjTcQEitCJclkuYk9Q" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="LFxvD31Yj0GGjFItDGX_mg" isDefault="1">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="69" />
+                    </Parameter>
+                    <Parameter id="o8spaT7_N02PVvSJvJhXNw" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="AGiWTt8CvEmeuesoKmPNgw" isDefault="1">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+                    </Parameter>
+                  </Children>
+                </Container>
+                <Parameter id="PiLX70Ian0eQULAxfzZkFQ" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="QsEW-YdRnE2ni5bwzVMxFQ" isDefault="1" displayUnit="cm²">
+                  <Tags>
+                    <Tag value="Neighborhood: Interstitial / Intracellular" />
+                  </Tags>
+                  <Info min="0" flag="122" seq="5" ref="0" bb="32" group="105" />
+                </Parameter>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="_55aUeDXakSk-m3bUAr3Jw" name="Heart_pls_Heart_bc" description="Neighborhood between Heart/Plasma and Heart/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="--ffw1zMZEOBxhdNSV1Q1w" secondNeighbor="XGjCqmNgsEiMW9ot69l81A">
+              <Tags>
+                <Tag value="Neighborhood: Plasma / BloodCells" />
+              </Tags>
+              <Children>
+                <Container id="5A7uY33qNEG3IUhFGhT0fw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+                <Parameter id="BnPuaiJjA02EbzLUtb8BqA" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="xH6OXEC65ESnPJ2unASWQA" isDefault="1" displayUnit="cm²">
+                  <Tags>
+                    <Tag value="Neighborhood: Plasma / BloodCells" />
+                  </Tags>
+                  <Info min="0" flag="122" seq="7" ref="0" bb="32" group="104" />
+                </Parameter>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="MBnJHEc62EyzbOejhkI0FA" name="Heart_pls_Heart_int" description="Neighborhood between Heart/Plasma and Heart/Interstitial" mode="Logical" containerType="Neighborhood" firstNeighbor="--ffw1zMZEOBxhdNSV1Q1w" secondNeighbor="1J0PG5NZq06wlO8fgAT1TQ">
+              <Tags>
+                <Tag value="Neighborhood: Plasma / Interstitial" />
+              </Tags>
+              <Children>
+                <Container id="JY-9v9o85UOoEUiuyC5rgQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="BjciWCN5t0qQXIfZHR0jjQ" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
+                      <ValueOrigin id="49" source="Other" method="Assumption" description="Assumption: very fast exchange" />
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="77" />
+                    </Parameter>
+                    <Parameter id="I67UQvaHA0O8QdnIqvK0LA" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="iKUspopJzEClLaOxGRLgvw" isDefault="1">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="70" />
+                    </Parameter>
+                  </Children>
+                </Container>
+                <Parameter id="rn3hBrbX_EakI8ivjAkCuw" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="YX57qmODbU-M9-4csS_AyA" isDefault="1" displayUnit="cm²">
+                  <Tags>
+                    <Tag value="Neighborhood: Plasma / Interstitial" />
+                  </Tags>
+                  <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                  <Info min="0" flag="122" seq="5" ref="0" bb="32" group="106" />
+                </Parameter>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="VS4KLMKOvE6eFKM0GfH7pA" name="Heart_pls_VenousBlood_pls" description="Neighborhood between Heart/Plasma and Venous Blood/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="--ffw1zMZEOBxhdNSV1Q1w" secondNeighbor="OW9eeGpb1Ui7R75zcOETVQ">
+              <Tags>
+                <Tag value="Neighborhood: Plasma / Plasma" />
+              </Tags>
+              <Children>
+                <Container id="V17PWf2Qcki6sri9ABin8A" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="_nYV3dbSnUSSrAYI4IqIMw" name="Kidney_bc_VenousBlood_bc" description="Neighborhood between Kidney/Blood Cells and Venous Blood/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="fpo7n9IKhEKtWLMWgD88GQ" secondNeighbor="Psihdre1OUqL7biUDEcQDw">
+              <Tags>
+                <Tag value="Neighborhood: BloodCells / BloodCells" />
+              </Tags>
+              <Children>
+                <Container id="8r5Wc-MB7E-UOZX1xKGgDQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="hb3YWiJ60USTJ2FKIPGeHw" name="Kidney_int_Kidney_cell" description="Neighborhood between Kidney/Interstitial and Kidney/Intracellular" mode="Logical" containerType="Neighborhood" firstNeighbor="80QMPHaFAUOAEMdImEADzw" secondNeighbor="CUgealQGGUa_yk3fJucd5w">
+              <Tags>
+                <Tag value="Neighborhood: Interstitial / Intracellular" />
+              </Tags>
+              <Children>
+                <Container id="94emkA3JSUeOHjXs1eIs3g" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="eNXJcYnfDEqvoxgtFZcswg" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="pn4TOZacr0GWHd9xAwFj8g" isDefault="1" displayUnit="cm/min">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="78" />
+                    </Parameter>
+                    <Parameter id="xJMo2eiFik21IB2wif5afA" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="QkTJVxVP3Ee97Zuh3Lg62w" isDefault="1" displayUnit="cm/min">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="76" />
+                    </Parameter>
+                    <Parameter id="DOMphS2ncEmDabe_bGlhJQ" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="SZrmcd1JDEW6MIjlHsCCew" isDefault="1" displayUnit="l/min">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="-ZgSW6lKAkae9K3Fc3NfTw" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="y659fcMlZEKHrLpFwmHmIw" isDefault="1" displayUnit="l/min">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="fThOXDjthUSgxNUusnmHOQ" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="UgZ8q0MWoUqtJhxPStVohw" isDefault="1">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="NpX5k3oKVESTnVZvfQFlug" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="UgZ8q0MWoUqtJhxPStVohw" isDefault="1">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="XLTa66vFD0G7ZvantZ3pQQ" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="LFxvD31Yj0GGjFItDGX_mg" isDefault="1">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="69" />
+                    </Parameter>
+                    <Parameter id="Vj-tWPWvBE6Jf0KjJ7kAfQ" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="AGiWTt8CvEmeuesoKmPNgw" isDefault="1">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+                    </Parameter>
+                  </Children>
+                </Container>
+                <Parameter id="lJbRTFcO0kSFpzyz9NBDeA" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SvRlXiAuFkCoyheS7hsGLg" isDefault="1" displayUnit="cm²">
+                  <Tags>
+                    <Tag value="Neighborhood: Interstitial / Intracellular" />
+                  </Tags>
+                  <Info min="0" flag="122" seq="6" ref="0" bb="32" group="105" />
+                </Parameter>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="wDCRpJNz2k6kaS1f5U2cnQ" name="Kidney_cell_Kidney_ur" description="Neighborhood between Kidney/Intracellular and Kidney/Urine" mode="Logical" containerType="Neighborhood" firstNeighbor="CUgealQGGUa_yk3fJucd5w" secondNeighbor="iW_tZ2dDfEmYSkQBNj57aQ">
+              <Tags>
+                <Tag value="Neighborhood: Intracellular / Urine" />
+              </Tags>
+              <Children>
+                <Container id="gBWkh62CJEW9fBR3YlUJvw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="e_Zzzoh3kk27ExDjmodGmQ" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="LPqANrUMBk2yj0xbB9-f-Q" isDefault="1">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+                    </Parameter>
+                  </Children>
+                </Container>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="Bkw4-Xjg4UaSgoYf3DZbjg" name="Kidney_pls_Kidney_bc" description="Neighborhood between Kidney/Plasma and Kidney/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="g0ppnZPQBkqwKVu3lsxWKw" secondNeighbor="fpo7n9IKhEKtWLMWgD88GQ">
+              <Tags>
+                <Tag value="Neighborhood: Plasma / BloodCells" />
+              </Tags>
+              <Children>
+                <Container id="wkN3RS4RWUCPpx2DIah0cg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+                <Parameter id="suNRnCGX2k-_CgaSWaPQlg" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="xH6OXEC65ESnPJ2unASWQA" isDefault="1" displayUnit="cm²">
+                  <Tags>
+                    <Tag value="Neighborhood: Plasma / BloodCells" />
+                  </Tags>
+                  <Info min="0" flag="122" seq="8" ref="0" bb="32" group="104" />
+                </Parameter>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="WPdFJS9SgU67RYXl9C3N-Q" name="Kidney_pls_Kidney_int" description="Neighborhood between Kidney/Plasma and Kidney/Interstitial" mode="Logical" containerType="Neighborhood" firstNeighbor="g0ppnZPQBkqwKVu3lsxWKw" secondNeighbor="80QMPHaFAUOAEMdImEADzw">
+              <Tags>
+                <Tag value="Neighborhood: Plasma / Interstitial" />
+              </Tags>
+              <Children>
+                <Container id="v2BP8fBlQkSObLtdWbguWg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="_-Hreyk2L0iJf3Ftw34v5Q" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
+                      <ValueOrigin id="49" source="Other" method="Assumption" description="Assumption: very fast exchange" />
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="77" />
+                    </Parameter>
+                    <Parameter id="F8_J6LRcI0ODWso0Q-mSDA" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="iKUspopJzEClLaOxGRLgvw" isDefault="1">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="70" />
+                    </Parameter>
+                  </Children>
+                </Container>
+                <Parameter id="wxW7gVpLvU6w38csn1NtbA" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="YX57qmODbU-M9-4csS_AyA" isDefault="1" displayUnit="cm²">
+                  <Tags>
+                    <Tag value="Neighborhood: Plasma / Interstitial" />
+                  </Tags>
+                  <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                  <Info min="0" flag="122" seq="6" ref="0" bb="32" group="106" />
+                </Parameter>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="WMfTeG3csEiKm3MlRVpr1w" name="Kidney_pls_Kidney_ur" description="Neighborhood between Kidney/Plasma and Kidney/Urine" mode="Logical" containerType="Neighborhood" firstNeighbor="g0ppnZPQBkqwKVu3lsxWKw" secondNeighbor="iW_tZ2dDfEmYSkQBNj57aQ">
+              <Tags>
+                <Tag value="Neighborhood: Plasma / Urine" />
+              </Tags>
+              <Children>
+                <Container id="r22oaZL2aUqTIQ4hQywsyw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="dm4SsOzLmEeBUJYzV9nhTw" name="Kidney_pls_VenousBlood_pls" description="Neighborhood between Kidney/Plasma and Venous Blood/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="g0ppnZPQBkqwKVu3lsxWKw" secondNeighbor="OW9eeGpb1Ui7R75zcOETVQ">
+              <Tags>
+                <Tag value="Neighborhood: Plasma / Plasma" />
+              </Tags>
+              <Children>
+                <Container id="-PO7eEmFpUu-het_s5EG4g" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="bHAMUvo_Kk2VJz9A6EvrXw" name="Lumen_uje_UpperJejunum_pls" description="Neighborhood between Lumen/Upper Jejunum and Mucosa/Upper Jejunum/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="B36E9D-lFUOd3Jraml_2Kg" secondNeighbor="ZKtVpdVbAkeG3MsVGPjvZA">
+              <Tags>
+                <Tag value="Neighborhood: UpperJejunum / Plasma" />
+              </Tags>
+              <Children>
+                <Container id="2zsYOgQ7KUeVcotuX1Vq4Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="y_GnQj8PRUOi_i3UfpXBeA" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="uKzg5qsit06VAeEp5xibnA" isDefault="1" displayUnit="µmol/min">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                    </Parameter>
+                    <Parameter id="zclYRUUxzEG1lHA-a_fGJQ" name="Sum of active process rates" description="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="5sKqjuv3WE2Nr_cTaUCUkQ" isDefault="1" displayUnit="µmol/min">
+                      <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                    </Parameter>
+                    <Parameter id="i3oen549jEu3zAbSH3gf-g" name="Sum of passive process rates" description="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="CxnCjO7-kUCjpt84KomgXw" isDefault="1" displayUnit="µmol/min">
+                      <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                    </Parameter>
+                  </Children>
+                </Container>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="NrdltjsYP0a7vDQWI5nJ6g" name="Lumen_uje_UpperJejunum_cell" description="Neighborhood between Lumen/Upper Jejunum and Mucosa/Upper Jejunum/Intracellular" mode="Logical" containerType="Neighborhood" firstNeighbor="B36E9D-lFUOd3Jraml_2Kg" secondNeighbor="-Du8nsEYSUmtfhASJQIGtA">
+              <Tags>
+                <Tag value="Neighborhood: UpperJejunum / Intracellular" />
+              </Tags>
+              <Children>
+                <Container id="jM_GdIILY0eQnkQM3Rp5fw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="KM4fB1sH7EGziV7R0vKYXg" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="q0YooqvoU0qrUqycI7T_vw" isDefault="1" displayUnit="µmol/min">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                    </Parameter>
+                    <Parameter id="AuYYV-YMjUu1pilPvsjX-w" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="2vtZBgPdHESzFsyX5jWdxw" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="2uNAked-OUqDPl2pgu-pJw" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="J07S_NBj0kuLL902KgFuKg" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="IQt1wcw4Kk6xbJ8LTAt6mg" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="hv1yuUWZSEacngh-4AFLGw" isDefault="1">
+                      <Info min="0" flag="36" seq="1" ref="0" bb="2" group="67" />
+                    </Parameter>
+                    <Parameter id="_u9dEnEIFUqf4hgtObIJkA" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="a8sr3g9pCEaE2bkNS5Sadg" isDefault="1">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+                    </Parameter>
+                    <Parameter id="lRzGIqHIPkG-NQoSh-0J7A" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="0acefClmxUSAhyraL0v7UA" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="rDKXyI_tnUq60BzwZ7NhTg" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="El15YtuX6keaW1PAleyuBQ" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="195icvo7OkmTnmPIcaP91w" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="27eSzHkQ3Umh5UZeqHG6aQ" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="OV0imSb1v0q2DsdeGJ1zfg" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="MFpVdInbNE-cKxWJrXVfXA" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="a7kw_AakVE65eA0Zogrcng" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="0b4LjT2SYkCetYN153ppjQ" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="Ie2XQPQDgEW9p47Aiq7g6A" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="YzJvRkHMtUeiQyO2fhP81g" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="gKUsvOO7ZEWLF20OvledFg" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Ap07gK_0Pk-62qv7f9OnrQ" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="CUubbGaq6Uq-2VfMIKBD4Q" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="nVfYZ66FF0W84y9RBYsn8g" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="1MaYojutiE-Rawth830lcA" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="gVsmm42vjUCp5xgwTI9NtA" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="W6Z6mmrhsEmKUhwE9J3lhA" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="tE3kbrj5vEq-h8ChtOQtHA" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="hgv0xAI_80uKgYPtTZkqBQ" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="4dKbSKIcqEOpuVa3g3kiFA" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="Rg9UQhrnfkaSlKEP4v1dyQ" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Yqc1pqXfwUu4RTTUuBnOMw" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="gL7YzVE3WkmGyrPgLk1jGA" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="kNxHC5F-a0SRE5tzNBa5Tw" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="SDlKBlIDW0280LCt4JOIcw" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="o3bt8HMD8k-qhDrXNRJPKw" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="tTNN-nW27kugwCk4poZuTQ" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="WBNyhWEmyEq682ssPupytg" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="N96OfMBNykKK2E6v2jB73g" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="hfJ8fmA9TU-M1chssktruQ" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="TDNAYG10n0Gn4nHmRZCvsA" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="JAt57xHu6068UYo-USk-CQ" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="mciMcsT980Ok0AXDaNzZ9A" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CIta8XEcZ0-vg6OK2e7YMg" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="CKkQpqlyTkmCE0QGgBNLnA" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ggTKHPU3-ESxtInpiqhz0Q" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="iZ6RtVTqs0mu1Z8v083cZw" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TIMTClcjEkWa2Jrpm18ahQ" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="Qi6Kc2RBikmBigotDjUpTg" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="OSp6wupiGUm1ZDNcKvvKkA" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="e4jehDOxU0u9ALSXT1WLPg" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="QGKMNC3BIU-L8isldgY-8A" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="ukgBFdS0XkaNDbvWy4n3xA" name="Sum of active process rates" description="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="5sKqjuv3WE2Nr_cTaUCUkQ" isDefault="1" displayUnit="µmol/min">
+                      <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                    </Parameter>
+                    <Parameter id="8Ry_Dhf0CEK2BH_N-SEEvw" name="Sum of passive process rates" description="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="CxnCjO7-kUCjpt84KomgXw" isDefault="1" displayUnit="µmol/min">
+                      <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                    </Parameter>
+                  </Children>
+                </Container>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="mb8MT2TB_kKKURyutJW33g" name="UpperJejunum_pls_PortalVein_pls" description="Neighborhood between Upper Jejunum/Plasma and PortalVein/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="ZKtVpdVbAkeG3MsVGPjvZA" secondNeighbor="7wRB5qMJl0aPiDibnmji6g">
+              <Tags>
+                <Tag value="Neighborhood: Plasma / Plasma" />
+              </Tags>
+              <Children>
+                <Container id="t5gReqosEk2y2jpWQWur_w" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="j7mZcDltZkSKq0XF44embQ" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="XpzF09V4WECHn0Y8QxGOGA" isDefault="1" displayUnit="µmol/min">
+                      <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                    </Parameter>
+                  </Children>
+                </Container>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="yVceokSLq02FUPKA51aM3w" name="UpperJejunum_bc_PortalVein_bc" description="Neighborhood between Upper Jejunum/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="TE4MZUgC30mHln4P6rXnUg" secondNeighbor="KB1_4NK_sU6lDGk5n9VoOQ">
+              <Tags>
+                <Tag value="Neighborhood: BloodCells / BloodCells" />
+              </Tags>
+              <Children>
+                <Container id="bhDl3AUw-UuiUtK4WdKNQw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="j9ILbK203kKgl3vFiouqSw" name="Mass transfer rate (mucosa to portal vein blood cells)" description="Mass transfer rate (mucosa to portal vein blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="8RqexjECt0iuSu_Ga-vZ2Q" isDefault="1" displayUnit="µmol/min">
+                      <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                    </Parameter>
+                  </Children>
+                </Container>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="nNCi5dlGHke19ivRBlDTnw" name="Lumen_lje_LowerJejunum_pls" description="Neighborhood between Lumen/Lower Jejunum and Mucosa/Lower Jejunum/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="d6r-EDw0QkWFAW4A9RaMOg" secondNeighbor="s7paVHLpgU-ARIQEjrTkow">
+              <Tags>
+                <Tag value="Neighborhood: LowerJejunum / Plasma" />
+              </Tags>
+              <Children>
+                <Container id="WB1aYQvZmkS2iYNncsfepg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="awKT_FYqDEm6E9mqY487aQ" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="uKzg5qsit06VAeEp5xibnA" isDefault="1" displayUnit="µmol/min">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                    </Parameter>
+                    <Parameter id="OIS7T3yoCEi5cL5RagPgnw" name="Sum of active process rates" description="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="5sKqjuv3WE2Nr_cTaUCUkQ" isDefault="1" displayUnit="µmol/min">
+                      <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                    </Parameter>
+                    <Parameter id="w7Ei7VvrM0Gn7bWfH5NhZQ" name="Sum of passive process rates" description="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="CxnCjO7-kUCjpt84KomgXw" isDefault="1" displayUnit="µmol/min">
+                      <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                    </Parameter>
+                  </Children>
+                </Container>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="4vXUBAQksU-enhrWEiigoQ" name="Lumen_lje_LowerJejunum_cell" description="Neighborhood between Lumen/Lower Jejunum and Mucosa/Lower Jejunum/Intracellular" mode="Logical" containerType="Neighborhood" firstNeighbor="d6r-EDw0QkWFAW4A9RaMOg" secondNeighbor="8bvEwbMCp0GhYbP0b2MTKw">
+              <Tags>
+                <Tag value="Neighborhood: LowerJejunum / Intracellular" />
+              </Tags>
+              <Children>
+                <Container id="f5M0jSzB8kGuH-vMirPt9g" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="63-QmnPnJEmoK9i4ZgznDA" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="q0YooqvoU0qrUqycI7T_vw" isDefault="1" displayUnit="µmol/min">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                    </Parameter>
+                    <Parameter id="HGcvgjqQ9kSO1xU4P6hUXQ" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="2vtZBgPdHESzFsyX5jWdxw" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="U4X6HnSj6E2q58gSNFwiGA" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="J07S_NBj0kuLL902KgFuKg" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="ex-JLsqsvkiX5MQdJS3PdQ" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="cYMdRMBEBUeT_pnqpij1lg" isDefault="1">
+                      <Info min="0" flag="36" seq="1" ref="0" bb="2" group="67" />
+                    </Parameter>
+                    <Parameter id="UfHHArGCDUeZmCyDGlUiUw" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="jJgMnGk1hUqY-rA0Vh1sDQ" isDefault="1">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+                    </Parameter>
+                    <Parameter id="_pTQV-3Mx02Y4HioyZQx5g" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="0acefClmxUSAhyraL0v7UA" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="9zE43LDeDkKVjVrCqabuzw" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="El15YtuX6keaW1PAleyuBQ" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="V2IVYw0Dl02QmVk8DLW0mw" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="27eSzHkQ3Umh5UZeqHG6aQ" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="XFG0T5Scf0CB8OetSjmGZA" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="MFpVdInbNE-cKxWJrXVfXA" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="9OzBobzrEEG7ZKZCQh_ESg" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="0b4LjT2SYkCetYN153ppjQ" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="AQOR1hScpkyDCa3RNNo5Tg" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="YzJvRkHMtUeiQyO2fhP81g" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="UFsveRWBNEaUqrLqILaQkw" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Ap07gK_0Pk-62qv7f9OnrQ" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="zMeqHqPbq0y6l2ltAiiunw" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="nVfYZ66FF0W84y9RBYsn8g" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="9dBZ2e00B0yp9BsLuKRK8w" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="gVsmm42vjUCp5xgwTI9NtA" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="lGSSjKJFxEqFBch5XtZRVA" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="tE3kbrj5vEq-h8ChtOQtHA" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="Xx4A6ol7CUGu-S1XolCj0A" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="4dKbSKIcqEOpuVa3g3kiFA" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="yYGy0AWwc0ug-Is4pOv6aA" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Yqc1pqXfwUu4RTTUuBnOMw" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="vqkGeCOsH0eb_lqWFNfWOA" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="kNxHC5F-a0SRE5tzNBa5Tw" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="okg-f88czUS-rPPz3E0C0Q" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="o3bt8HMD8k-qhDrXNRJPKw" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="3WhAntngJUWnJ_4ZNQ9pBw" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="WBNyhWEmyEq682ssPupytg" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="3D1F4tbXTEeBnuktfe-B4A" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="hfJ8fmA9TU-M1chssktruQ" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="EZHo607u_EaWMU_qhitwyA" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="JAt57xHu6068UYo-USk-CQ" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="lxrqJTYg1EKb9M5UVCleEg" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CIta8XEcZ0-vg6OK2e7YMg" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="ZCM1_scf70umFrrkFRSMMA" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ggTKHPU3-ESxtInpiqhz0Q" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="JolpvmUtwkKuVRPMYlVktg" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TIMTClcjEkWa2Jrpm18ahQ" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="q6glLKpggkqMLlnPxNYeIA" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="OSp6wupiGUm1ZDNcKvvKkA" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="1r5gjD3QBESBbLAHr-KiVg" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="QGKMNC3BIU-L8isldgY-8A" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="a1AKnnlarUC6P0BkF4kcFQ" name="Sum of active process rates" description="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="5sKqjuv3WE2Nr_cTaUCUkQ" isDefault="1" displayUnit="µmol/min">
+                      <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                    </Parameter>
+                    <Parameter id="BB0QIRKLy0yWxKI0OyxiWQ" name="Sum of passive process rates" description="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="CxnCjO7-kUCjpt84KomgXw" isDefault="1" displayUnit="µmol/min">
+                      <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                    </Parameter>
+                  </Children>
+                </Container>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="gHixD_0gjE-JrfbYiWgCYg" name="LowerJejunum_pls_PortalVein_pls" description="Neighborhood between Lower Jejunum/Plasma and PortalVein/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="s7paVHLpgU-ARIQEjrTkow" secondNeighbor="7wRB5qMJl0aPiDibnmji6g">
+              <Tags>
+                <Tag value="Neighborhood: Plasma / Plasma" />
+              </Tags>
+              <Children>
+                <Container id="Oak2buRDd0OYmnIBe9FTfQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="gHH_L4EqHUqJcuOOScG6Aw" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="XpzF09V4WECHn0Y8QxGOGA" isDefault="1" displayUnit="µmol/min">
+                      <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                    </Parameter>
+                  </Children>
+                </Container>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="_eRGt2ina02ZckcmmpcM3g" name="LowerJejunum_bc_PortalVein_bc" description="Neighborhood between Lower Jejunum/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="VukDQ4kjKEK6n1m_HO3RKg" secondNeighbor="KB1_4NK_sU6lDGk5n9VoOQ">
+              <Tags>
+                <Tag value="Neighborhood: BloodCells / BloodCells" />
+              </Tags>
+              <Children>
+                <Container id="epJxORPrqkiLsu5qwnVleA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="lSumTlG1E0O8D9TnKwuFhg" name="Mass transfer rate (mucosa to portal vein blood cells)" description="Mass transfer rate (mucosa to portal vein blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="8RqexjECt0iuSu_Ga-vZ2Q" isDefault="1" displayUnit="µmol/min">
+                      <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                    </Parameter>
+                  </Children>
+                </Container>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="-QBHul4X6UGuZ1LErGEc3A" name="Lumen_sto_Lumen_duo" description="Neighborhood between Lumen/Stomach and Lumen/Duodenum" mode="Logical" containerType="Neighborhood" firstNeighbor="x_RtXB5WrkSeYcZWpjSEKA" secondNeighbor="Uh4b9ySQo0-IEUYhzejKww">
+              <Tags>
+                <Tag value="Neighborhood: Stomach / Duodenum" />
+              </Tags>
+              <Children>
+                <Container id="KNVSaDR18kiU8BkAobpHoQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="rOcz82qxAEeo_JNyh7v21w" name="Oral mass absorbed" description="Oral mass absorbed from Lumen into mucosa" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" formula="dUb6Z17llk2BO1fNDqmvbw" isDefault="1" displayUnit="µmol">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                    </Parameter>
+                  </Children>
+                </Container>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="FvY_Qw1FVEitRNvsrmFyLQ" name="Lumen_duo_Lumen_uje" description="Neighborhood between Lumen/Duodenum and Lumen/Upper Jejunum" mode="Logical" containerType="Neighborhood" firstNeighbor="Uh4b9ySQo0-IEUYhzejKww" secondNeighbor="B36E9D-lFUOd3Jraml_2Kg">
+              <Tags>
+                <Tag value="Neighborhood: Duodenum / UpperJejunum" />
+              </Tags>
+              <Children>
+                <Container id="QpenbBK0c0Sbe37O5vjakw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="-rYw2F7qnEeFNecoLQJqug" name="Lumen_uje_Lumen_lje" description="Neighborhood between Lumen/Upper Jejunum and Lumen/Lower Jejunum" mode="Logical" containerType="Neighborhood" firstNeighbor="B36E9D-lFUOd3Jraml_2Kg" secondNeighbor="d6r-EDw0QkWFAW4A9RaMOg">
+              <Tags>
+                <Tag value="Neighborhood: UpperJejunum / LowerJejunum" />
+              </Tags>
+              <Children>
+                <Container id="ou8cPpGF30GE5mYj4taV6Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="W8zAKJigbkK-doQaGjMMLw" name="Lumen_lje_Lumen_uil" description="Neighborhood between Lumen/Lower Jejunum and Lumen/Upper Ileum" mode="Logical" containerType="Neighborhood" firstNeighbor="d6r-EDw0QkWFAW4A9RaMOg" secondNeighbor="cmRRlhfsYkmrjs8gJ_QPNg">
+              <Tags>
+                <Tag value="Neighborhood: LowerJejunum / UpperIleum" />
+              </Tags>
+              <Children>
+                <Container id="i2UTwM7gjEi9RNm8al7Q9A" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="Kddv8lcMd0mAVk0u8RgKVA" name="Lumen_uil_Lumen_lil" description="Neighborhood between Lumen/Upper Ileum and Lumen/Lower Ileum" mode="Logical" containerType="Neighborhood" firstNeighbor="cmRRlhfsYkmrjs8gJ_QPNg" secondNeighbor="wen_VH77NE2ORWa-gn7jMw">
+              <Tags>
+                <Tag value="Neighborhood: UpperIleum / LowerIleum" />
+              </Tags>
+              <Children>
+                <Container id="9mkGcvTTG0mOkQFEN9p8JQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="h6ZbLv_Kr0mGFrvQMq6-Ug" name="Lumen_lil_Lumen_cae" description="Neighborhood between Lumen/Lower Ileum and Lumen/Cecum" mode="Logical" containerType="Neighborhood" firstNeighbor="wen_VH77NE2ORWa-gn7jMw" secondNeighbor="3tZuU9v7b0uAi8jCQ6JTTQ">
+              <Tags>
+                <Tag value="Neighborhood: LowerIleum / Caecum" />
+              </Tags>
+              <Children>
+                <Container id="8Ik_R8Yx4UKh3Ve_ZXQdrg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="GcLs3e_Pu0SQbcehBtlANA" name="Lumen_cae_Lumen_colasc" description="Neighborhood between Lumen/Cecum and Lumen/Colon Ascendens" mode="Logical" containerType="Neighborhood" firstNeighbor="3tZuU9v7b0uAi8jCQ6JTTQ" secondNeighbor="YMbLwVT-lkaxj25aTkoiQg">
+              <Tags>
+                <Tag value="Neighborhood: Caecum / ColonAscendens" />
+              </Tags>
+              <Children>
+                <Container id="6F-CuYGbnUaQOjrOPKk2kw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="vi7YeksOv0eIsEb9Oek_Hg" name="Lumen_colasc_Lumen_coltrans" description="Neighborhood between Lumen/Colon Ascendens and Lumen/Colon Transversum" mode="Logical" containerType="Neighborhood" firstNeighbor="YMbLwVT-lkaxj25aTkoiQg" secondNeighbor="DdIHOXwYBUCq93VVa5oJ7g">
+              <Tags>
+                <Tag value="Neighborhood: ColonAscendens / ColonTransversum" />
+              </Tags>
+              <Children>
+                <Container id="kss-rp3jzUC_CeP6Cpe6Ww" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="7x-Yv5GAZEymoozK8MuMnA" name="Lumen_coltrans_Lumen_coldesc" description="Neighborhood between Lumen/Colon Transversum and Lumen/Colon Descendens" mode="Logical" containerType="Neighborhood" firstNeighbor="DdIHOXwYBUCq93VVa5oJ7g" secondNeighbor="ibG_MtDU_UeUGcopqh_FaQ">
+              <Tags>
+                <Tag value="Neighborhood: ColonTransversum / ColonDescendens" />
+              </Tags>
+              <Children>
+                <Container id="FGv1rWbcAUOSBflDpB1y0w" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="Oybj4gMImkWEckeZP04TXA" name="Lumen_coldesc_Lumen_colsigm" description="Neighborhood between Lumen/Colon Descendens and Lumen/Colon Sigmoid" mode="Logical" containerType="Neighborhood" firstNeighbor="ibG_MtDU_UeUGcopqh_FaQ" secondNeighbor="sHZCByHK30-UYnBeZG7BKw">
+              <Tags>
+                <Tag value="Neighborhood: ColonDescendens / ColonSigmoid" />
+              </Tags>
+              <Children>
+                <Container id="dz7cRdmXkkm2tRVpjnfxyw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="xgMd6ekkTkuTcaIidTe35Q" name="Lumen_colsigm_Lumen_rect" description="Neighborhood between Lumen/Colon Sigmoid and Lumen/Rectum" mode="Logical" containerType="Neighborhood" firstNeighbor="sHZCByHK30-UYnBeZG7BKw" secondNeighbor="WXUsQpIjG0WT7kojm5PhDg">
+              <Tags>
+                <Tag value="Neighborhood: ColonSigmoid / Rectum" />
+              </Tags>
+              <Children>
+                <Container id="veAlgpQzI0CpcNiRdwkE0g" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="v_uuUgi7a0-Oy-ksicHaGA" name="Lumen_rect_Lumen_fec" description="Neighborhood between Lumen/Rectum and Lumen/Feces" mode="Logical" containerType="Neighborhood" firstNeighbor="WXUsQpIjG0WT7kojm5PhDg" secondNeighbor="o0KEj_vMWUWC2aTyBZvYmg">
+              <Tags>
+                <Tag value="Neighborhood: Rectum / Feces" />
+              </Tags>
+              <Children>
+                <Container id="6J7DQNm670KxbA56CSjjLQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="37vquyDJj0SlLE7yta7AEw" name="Stomach_bc_PortalVein_bc" description="Neighborhood between Stomach/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="zHyBX88dpUCaGtm-lIfGkA" secondNeighbor="KB1_4NK_sU6lDGk5n9VoOQ">
+              <Tags>
+                <Tag value="Neighborhood: BloodCells / BloodCells" />
+              </Tags>
+              <Children>
+                <Container id="t6_rJS43qESaL_iEN-6PtA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="C8ssU2XUQE-aZCaJHahazw" name="Stomach_int_Stomach_cell" description="Neighborhood between Stomach/Interstitial and Stomach/Intracellular" mode="Logical" containerType="Neighborhood" firstNeighbor="NcLdQmZ2c0Wg97SMqL1wjg" secondNeighbor="Pv-3tRq_Q0yUw9QxgJnHNw">
+              <Tags>
+                <Tag value="Neighborhood: Interstitial / Intracellular" />
+              </Tags>
+              <Children>
+                <Container id="HKdBGwf1Jk61-HcjtOMtGA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="_8SeYrmbU0awvPcMw4pnpw" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="pn4TOZacr0GWHd9xAwFj8g" isDefault="1" displayUnit="cm/min">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="78" />
+                    </Parameter>
+                    <Parameter id="A3aQ-bjv50-Dp23jyXrpyg" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="QkTJVxVP3Ee97Zuh3Lg62w" isDefault="1" displayUnit="cm/min">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="76" />
+                    </Parameter>
+                    <Parameter id="L5WWdtXZ-0ydx_wLAnl-CA" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="SZrmcd1JDEW6MIjlHsCCew" isDefault="1" displayUnit="l/min">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="nUeCC35sy0SYsnnp9ZGbpA" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="y659fcMlZEKHrLpFwmHmIw" isDefault="1" displayUnit="l/min">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="ZbxVXrmHBEu3QrvHPqj2lA" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="UgZ8q0MWoUqtJhxPStVohw" isDefault="1">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="IJ2G1YCyYkSNNXF-VFa3QA" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="UgZ8q0MWoUqtJhxPStVohw" isDefault="1">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="4AoGgQub3U6p038fMBXjkQ" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="LFxvD31Yj0GGjFItDGX_mg" isDefault="1">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="69" />
+                    </Parameter>
+                    <Parameter id="JG0GkP5TcEu33hM7S_AHtg" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="AGiWTt8CvEmeuesoKmPNgw" isDefault="1">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+                    </Parameter>
+                  </Children>
+                </Container>
+                <Parameter id="iliOGcS7q0G8f7uoQZcMjQ" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Tpp6KUrtKUi5jWWnk1dJ0Q" isDefault="1" displayUnit="cm²">
+                  <Tags>
+                    <Tag value="Neighborhood: Interstitial / Intracellular" />
+                  </Tags>
+                  <Info min="0" flag="122" seq="17" ref="0" bb="32" group="105" />
+                </Parameter>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="VU9ZO6jyhkiybWdQTWt__w" name="Stomach_pls_PortalVein_pls" description="Neighborhood between Stomach/Plasma and PortalVein/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="gdyMOOU0gkaW4spE0BcIjA" secondNeighbor="7wRB5qMJl0aPiDibnmji6g">
+              <Tags>
+                <Tag value="Neighborhood: Plasma / Plasma" />
+              </Tags>
+              <Children>
+                <Container id="2UOWiMzMbUa4I35K7So-LQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="XQRPOu3tX0STYN-_XGUlmw" name="Stomach_pls_Stomach_bc" description="Neighborhood between Stomach/Plasma and Stomach/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="gdyMOOU0gkaW4spE0BcIjA" secondNeighbor="zHyBX88dpUCaGtm-lIfGkA">
+              <Tags>
+                <Tag value="Neighborhood: Plasma / BloodCells" />
+              </Tags>
+              <Children>
+                <Container id="KIANoMxKdkqqD4ABWDJVVw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+                <Parameter id="xqIRr-FhBkqzEgAPnKCRzw" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="xH6OXEC65ESnPJ2unASWQA" isDefault="1" displayUnit="cm²">
+                  <Tags>
+                    <Tag value="Neighborhood: Plasma / BloodCells" />
+                  </Tags>
+                  <Info min="0" flag="122" seq="20" ref="0" bb="32" group="104" />
+                </Parameter>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="mLlc7gDz7EugOj2JdodnEA" name="Stomach_pls_Stomach_int" description="Neighborhood between Stomach/Plasma and Stomach/Interstitial" mode="Logical" containerType="Neighborhood" firstNeighbor="gdyMOOU0gkaW4spE0BcIjA" secondNeighbor="NcLdQmZ2c0Wg97SMqL1wjg">
+              <Tags>
+                <Tag value="Neighborhood: Plasma / Interstitial" />
+              </Tags>
+              <Children>
+                <Container id="Hl-5z-_CnUeHO3cUPrsARQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="KEVk7A2QvUW2t98fOFtj0w" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
+                      <ValueOrigin id="49" source="Other" method="Assumption" description="Assumption: very fast exchange" />
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="77" />
+                    </Parameter>
+                    <Parameter id="wEOGLNf9J029_d-zI-Hq2A" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="iKUspopJzEClLaOxGRLgvw" isDefault="1">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="70" />
+                    </Parameter>
+                  </Children>
+                </Container>
+                <Parameter id="LaNTx4lPnk-d3GFpKOBLPw" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="YX57qmODbU-M9-4csS_AyA" isDefault="1" displayUnit="cm²">
+                  <Tags>
+                    <Tag value="Neighborhood: Plasma / Interstitial" />
+                  </Tags>
+                  <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                  <Info min="0" flag="122" seq="17" ref="0" bb="32" group="106" />
+                </Parameter>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="gPhmSmWlIkaZDhFydGu20w" name="Lumen_uil_UpperIleum_pls" description="Neighborhood between Lumen/Upper Ileum and Mucosa/Upper Ileum/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="cmRRlhfsYkmrjs8gJ_QPNg" secondNeighbor="ExfgzEZMLEKihI9r6OGmqA">
+              <Tags>
+                <Tag value="Neighborhood: UpperIleum / Plasma" />
+              </Tags>
+              <Children>
+                <Container id="urRWuSzwt0CSteGmxGVYRw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="hug-HPxCZkOsaCo6vDmN6A" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="uKzg5qsit06VAeEp5xibnA" isDefault="1" displayUnit="µmol/min">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                    </Parameter>
+                    <Parameter id="9z2oKvSG7UOhJGrezPzfcg" name="Sum of active process rates" description="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="5sKqjuv3WE2Nr_cTaUCUkQ" isDefault="1" displayUnit="µmol/min">
+                      <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                    </Parameter>
+                    <Parameter id="Fgwdhj05rEmpyirTHdfsZA" name="Sum of passive process rates" description="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="CxnCjO7-kUCjpt84KomgXw" isDefault="1" displayUnit="µmol/min">
+                      <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                    </Parameter>
+                  </Children>
+                </Container>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="XfJPobdsP0iP7f4bZ03SuA" name="Lumen_uil_UpperIleum_cell" description="Neighborhood between Lumen/Upper Ileum and Mucosa/Upper Ileum/Intracellular" mode="Logical" containerType="Neighborhood" firstNeighbor="cmRRlhfsYkmrjs8gJ_QPNg" secondNeighbor="L1bm6q9hXUaQWfjmYlWmTg">
+              <Tags>
+                <Tag value="Neighborhood: UpperIleum / Intracellular" />
+              </Tags>
+              <Children>
+                <Container id="mT9Bv0brHUKIt7voSwimBA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="Qx0MUqp3lEa9iPdf77tUUw" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="q0YooqvoU0qrUqycI7T_vw" isDefault="1" displayUnit="µmol/min">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                    </Parameter>
+                    <Parameter id="vUJB357ZdEC8TsK9Gu055w" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="2vtZBgPdHESzFsyX5jWdxw" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="mRCS2Zd2Ck2o01CbytnMXg" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="J07S_NBj0kuLL902KgFuKg" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="z4Zg72Z2iU-AHNZVPyOKXQ" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="sOLnUnH-o0CcEUobvoUVtA" isDefault="1">
+                      <Info min="0" flag="36" seq="1" ref="0" bb="2" group="67" />
+                    </Parameter>
+                    <Parameter id="3p5z-JsT9EypAxTA9D4g0g" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="NZZJ4zNQGU-dcSAVJbs_hA" isDefault="1">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+                    </Parameter>
+                    <Parameter id="f_QpANzQ0EG5WQDunz8d3g" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="0acefClmxUSAhyraL0v7UA" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="IprEJ9vzpEqEEaouXonHeQ" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="El15YtuX6keaW1PAleyuBQ" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="ZLnDoiInRE-N8EEUJOlGpw" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="27eSzHkQ3Umh5UZeqHG6aQ" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="AtsKCtrvuEatWgsobQOE_w" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="MFpVdInbNE-cKxWJrXVfXA" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="PXNaHF1R-UydFmCr8rPBGg" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="0b4LjT2SYkCetYN153ppjQ" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="pTTekgpnf0KA5DJ_IMOQAA" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="YzJvRkHMtUeiQyO2fhP81g" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="cP7PYoX_b0OiSn2cE9bE_g" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Ap07gK_0Pk-62qv7f9OnrQ" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="HA20MihhdEGFqVWaa9ZInA" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="nVfYZ66FF0W84y9RBYsn8g" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="CMJSDP5-oUmKyyqDx2iebg" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="gVsmm42vjUCp5xgwTI9NtA" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="6MmhMv2xtEyvbfxN1GCZPA" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="tE3kbrj5vEq-h8ChtOQtHA" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="aiCTnNrIzEW8rJpNnAsiaQ" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="4dKbSKIcqEOpuVa3g3kiFA" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="YbUaICXVWEqYozUjgSxzTA" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Yqc1pqXfwUu4RTTUuBnOMw" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="0m3mNRS3G0W61e4rz6cX5g" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="kNxHC5F-a0SRE5tzNBa5Tw" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="RN1JYXMRuU-5OLy4kgJohQ" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="o3bt8HMD8k-qhDrXNRJPKw" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="d08LzOOm1EKv-1dAOP1LYA" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="WBNyhWEmyEq682ssPupytg" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="2iyl4A19hk-3K9SqFq3ZJA" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="hfJ8fmA9TU-M1chssktruQ" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="UcKVEEXS60Gu8_B-Q-4qmg" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="JAt57xHu6068UYo-USk-CQ" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="yWrqWUcpKkuHVoRhXsJ1tQ" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CIta8XEcZ0-vg6OK2e7YMg" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="eE_hX1gxU0CCGPdxSEBZpA" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ggTKHPU3-ESxtInpiqhz0Q" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="XY7Hgw2Tq0CeCI8UI6ZP7Q" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TIMTClcjEkWa2Jrpm18ahQ" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="CjbgTswkS0SWWQeUDYTueg" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="OSp6wupiGUm1ZDNcKvvKkA" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="D4Dgi4dNmU-ro6w-yt6F1g" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="QGKMNC3BIU-L8isldgY-8A" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="eofzDu88_U2tVmiR0CmMhQ" name="Sum of active process rates" description="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="5sKqjuv3WE2Nr_cTaUCUkQ" isDefault="1" displayUnit="µmol/min">
+                      <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                    </Parameter>
+                    <Parameter id="ysIuaEIX1Uq-pin25wes9Q" name="Sum of passive process rates" description="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="CxnCjO7-kUCjpt84KomgXw" isDefault="1" displayUnit="µmol/min">
+                      <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                    </Parameter>
+                  </Children>
+                </Container>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="zbFRRihi1U2rg59QNnUfyA" name="UpperIleum_pls_PortalVein_pls" description="Neighborhood between Upper Ileum/Plasma and PortalVein/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="ExfgzEZMLEKihI9r6OGmqA" secondNeighbor="7wRB5qMJl0aPiDibnmji6g">
+              <Tags>
+                <Tag value="Neighborhood: Plasma / Plasma" />
+              </Tags>
+              <Children>
+                <Container id="n9pRVX3G60axPPTkfVVgpA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="KP5JSXjA5kOG6B6Gswc05w" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="XpzF09V4WECHn0Y8QxGOGA" isDefault="1" displayUnit="µmol/min">
+                      <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                    </Parameter>
+                  </Children>
+                </Container>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="uZAB67X5q0KcTZHDafEKJw" name="UpperIleum_bc_PortalVein_bc" description="Neighborhood between Upper Ileum/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="r0WtY-vx3UWxfs1sK8Zxcg" secondNeighbor="KB1_4NK_sU6lDGk5n9VoOQ">
+              <Tags>
+                <Tag value="Neighborhood: BloodCells / BloodCells" />
+              </Tags>
+              <Children>
+                <Container id="0oimq-2Bx0mj7acHjrjw-g" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="PtUiFBYzYEmexfFyD7tqHw" name="Mass transfer rate (mucosa to portal vein blood cells)" description="Mass transfer rate (mucosa to portal vein blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="8RqexjECt0iuSu_Ga-vZ2Q" isDefault="1" displayUnit="µmol/min">
+                      <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                    </Parameter>
+                  </Children>
+                </Container>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="tBua9aBL9k-cUS-AUxOQXw" name="SmallIntestine_bc_PortalVein_bc" description="Neighborhood between Small Intestine/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="E0vWo0BDME6DiS7jT6IlYg" secondNeighbor="KB1_4NK_sU6lDGk5n9VoOQ">
+              <Tags>
+                <Tag value="Neighborhood: BloodCells / BloodCells" />
+              </Tags>
+              <Children>
+                <Container id="GWRcyvAgsUacUxE6rOWhOw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="pOEGZa6rqE6Ef60ZyKF8bw" name="SmallIntestine_int_SmallIntestine_cell" description="Neighborhood between Small Intestine/Interstitial and Small Intestine/Intracellular" mode="Logical" containerType="Neighborhood" firstNeighbor="ePk4I1ZCKU-a5eZuJJCIJw" secondNeighbor="FrT86gSA5UCFxRthJxSZvA">
+              <Tags>
+                <Tag value="Neighborhood: Interstitial / Intracellular" />
+                <Tag value="Small intestine  neighborhood" />
+              </Tags>
+              <Children>
+                <Container id="LVTwUJbS9kypUUdXIFmZJg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="PNVkBH3BUUKQmHhnn_Q8OQ" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="pn4TOZacr0GWHd9xAwFj8g" isDefault="1" displayUnit="cm/min">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="78" />
+                    </Parameter>
+                    <Parameter id="MTyf30DM0EmWxzyE6aWrUQ" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="QkTJVxVP3Ee97Zuh3Lg62w" isDefault="1" displayUnit="cm/min">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="76" />
+                    </Parameter>
+                    <Parameter id="gjOxG8GH8kurvOnex0VByQ" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="SZrmcd1JDEW6MIjlHsCCew" isDefault="1" displayUnit="l/min">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="yTD7acdMZUChidlcp3OrIQ" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="y659fcMlZEKHrLpFwmHmIw" isDefault="1" displayUnit="l/min">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="FdqpcOSWM0-HJeNUuxAmgw" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="UgZ8q0MWoUqtJhxPStVohw" isDefault="1">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="qAQ2er3Grkecao7mG4Y6hA" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="UgZ8q0MWoUqtJhxPStVohw" isDefault="1">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="fp5rOnsHdUi7z5MCfCymvQ" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="LFxvD31Yj0GGjFItDGX_mg" isDefault="1">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="69" />
+                    </Parameter>
+                    <Parameter id="bgVsfU189UeI6Ay5zERt7A" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="AGiWTt8CvEmeuesoKmPNgw" isDefault="1">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+                    </Parameter>
+                  </Children>
+                </Container>
+                <Parameter id="zVb05zW6B0mhvLn5ezB-uw" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="BO9x1YEl20OHj4PcTuGyBg" isDefault="1" displayUnit="cm²">
+                  <Tags>
+                    <Tag value="Neighborhood: Interstitial / Intracellular" />
+                    <Tag value="Small intestine  neighborhood" />
+                  </Tags>
+                  <Info min="0" flag="122" seq="15" ref="0" bb="32" group="105" />
+                </Parameter>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="dOY4G39hQUuXpUE-IB8wqg" name="SmallIntestine_pls_PortalVein_pls" description="Neighborhood between Small Intestine/Plasma and PortalVein/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="7uENbPvU7kOunFwGm9NtzA" secondNeighbor="7wRB5qMJl0aPiDibnmji6g">
+              <Tags>
+                <Tag value="Neighborhood: Plasma / Plasma" />
+              </Tags>
+              <Children>
+                <Container id="mFmRNguo_0OqizaJDtnYeA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="V_m4fbLfpkOvDhaRPwnTqg" name="SmallIntestine_pls_SmallIntestine_bc" description="Neighborhood between Small Intestine/Plasma and Small Intestine/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="7uENbPvU7kOunFwGm9NtzA" secondNeighbor="E0vWo0BDME6DiS7jT6IlYg">
+              <Tags>
+                <Tag value="Neighborhood: Plasma / BloodCells" />
+                <Tag value="Small intestine  neighborhood" />
+              </Tags>
+              <Children>
+                <Container id="UilOidDxpEWGRFTeVxMDgw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+                <Parameter id="a56TkAlnoEKoY7A0_Gcl4A" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="cx-m9dLIjEq_fcm5rtTErg" isDefault="1" displayUnit="cm²">
+                  <Tags>
+                    <Tag value="Neighborhood: Plasma / BloodCells" />
+                    <Tag value="Small intestine  neighborhood" />
+                  </Tags>
+                  <Info min="0" flag="122" seq="18" ref="0" bb="32" group="104" />
+                </Parameter>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="y9PPIXzW906RL-lMfyHNFg" name="SmallIntestine_pls_SmallIntestine_int" description="Neighborhood between Small Intestine/Plasma and Small Intestine/Interstitial" mode="Logical" containerType="Neighborhood" firstNeighbor="7uENbPvU7kOunFwGm9NtzA" secondNeighbor="ePk4I1ZCKU-a5eZuJJCIJw">
+              <Tags>
+                <Tag value="Neighborhood: Plasma / Interstitial" />
+                <Tag value="Small intestine  neighborhood" />
+              </Tags>
+              <Children>
+                <Container id="6hlPasE0sEy3XdwJiznd1g" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="SF3oazAJlkyyd5_t56azDA" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
+                      <ValueOrigin id="49" source="Other" method="Assumption" description="Assumption: very fast exchange" />
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="77" />
+                    </Parameter>
+                    <Parameter id="9FI1myMs4Ee1oN9uj7BDOQ" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="iKUspopJzEClLaOxGRLgvw" isDefault="1">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="70" />
+                    </Parameter>
+                  </Children>
+                </Container>
+                <Parameter id="s6AqccUb_kiD5V8cWSvmQQ" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="0FlRc-zSNkat5Aao48Bp-A" isDefault="1" displayUnit="cm²">
+                  <Tags>
+                    <Tag value="Neighborhood: Plasma / Interstitial" />
+                    <Tag value="Small intestine  neighborhood" />
+                  </Tags>
+                  <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                  <Info min="0" flag="122" seq="15" ref="0" bb="32" group="106" />
+                </Parameter>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="etRnOAWoTU2-J1kRaMSGvQ" name="SmallIntestine_pls_Duodenum_pls" description="Neighborhood between Small Intestine/Plasma_ and Duodenum/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="7uENbPvU7kOunFwGm9NtzA" secondNeighbor="qCGoNzAmJUeTktSdRLCDpQ">
+              <Tags>
+                <Tag value="Neighborhood: Plasma / Plasma" />
+              </Tags>
+              <Children>
+                <Container id="BAO8H92z80yccS-BdN13_Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="m6K25CbM1kiVgHPtpvoANw" name="Mass transfer rate (intestine to mucosa plasma)" description="Mass transfer rate (intestine to mucosa plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="qIfhIqP5eEqwyfjkWwy98Q" isDefault="1" displayUnit="µmol/min">
+                      <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                    </Parameter>
+                  </Children>
+                </Container>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="QjwcEGQJfUSjk8FemWhPxQ" name="SmallIntestine_bc_Duodenum_bc" description="Neighborhood between Small Intestine/Blood Cells_ and Duodenum/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="E0vWo0BDME6DiS7jT6IlYg" secondNeighbor="r4SZfck0GEir1mEuobAUCg">
+              <Tags>
+                <Tag value="Neighborhood: BloodCells / BloodCells" />
+              </Tags>
+              <Children>
+                <Container id="isjvoJwTc0CJmQBUr9RXrQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="zv63JCQE9E2NQoWww5t_Cw" name="Mass transfer rate (intestine to mucosa blood cells)" description="Mass transfer rate (intestine to mucosa blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="zc-z__JGpk2IpJnqbvTzxQ" isDefault="1" displayUnit="µmol/min">
+                      <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                    </Parameter>
+                  </Children>
+                </Container>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="bs9qohkYzU-74Ies8h9BYA" name="SmallIntestine_pls_UpperJejunum_pls" description="Neighborhood between Small Intestine/Plasma_ and Upper Jejunum/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="7uENbPvU7kOunFwGm9NtzA" secondNeighbor="ZKtVpdVbAkeG3MsVGPjvZA">
+              <Tags>
+                <Tag value="Neighborhood: Plasma / Plasma" />
+              </Tags>
+              <Children>
+                <Container id="-8x0_N7-20e28vs6vMe8Tw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="SzaGS-zrTEOqj9ggwWy_RQ" name="Mass transfer rate (intestine to mucosa plasma)" description="Mass transfer rate (intestine to mucosa plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="qIfhIqP5eEqwyfjkWwy98Q" isDefault="1" displayUnit="µmol/min">
+                      <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                    </Parameter>
+                  </Children>
+                </Container>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="TVsDAeks_UOCjmf_UQsYtg" name="SmallIntestine_bc_UpperJejunum_bc" description="Neighborhood between Small Intestine/Blood Cells_ and Upper Jejunum/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="E0vWo0BDME6DiS7jT6IlYg" secondNeighbor="TE4MZUgC30mHln4P6rXnUg">
+              <Tags>
+                <Tag value="Neighborhood: BloodCells / BloodCells" />
+              </Tags>
+              <Children>
+                <Container id="rr440E3PN02cziUvJHLFSA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="qowKV2M0ZEG1N6gKNMaCNQ" name="Mass transfer rate (intestine to mucosa blood cells)" description="Mass transfer rate (intestine to mucosa blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="zc-z__JGpk2IpJnqbvTzxQ" isDefault="1" displayUnit="µmol/min">
+                      <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                    </Parameter>
+                  </Children>
+                </Container>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="ZjjRd_CYG0a_7iWgVWMu_Q" name="SmallIntestine_pls_LowerJejunum_pls" description="Neighborhood between Small Intestine/Plasma_ and Lower Jejunum/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="7uENbPvU7kOunFwGm9NtzA" secondNeighbor="s7paVHLpgU-ARIQEjrTkow">
+              <Tags>
+                <Tag value="Neighborhood: Plasma / Plasma" />
+              </Tags>
+              <Children>
+                <Container id="wcbV7pulF02XGauKvfGYfg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="-RLOTJVig0iiMUkwKfZKkA" name="Mass transfer rate (intestine to mucosa plasma)" description="Mass transfer rate (intestine to mucosa plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="qIfhIqP5eEqwyfjkWwy98Q" isDefault="1" displayUnit="µmol/min">
+                      <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                    </Parameter>
+                  </Children>
+                </Container>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="pCkuDKB2rEK6PQTx7ZlreA" name="SmallIntestine_bc_LowerJejunum_bc" description="Neighborhood between Small Intestine/Blood Cells_ and Lower Jejunum/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="E0vWo0BDME6DiS7jT6IlYg" secondNeighbor="VukDQ4kjKEK6n1m_HO3RKg">
+              <Tags>
+                <Tag value="Neighborhood: BloodCells / BloodCells" />
+              </Tags>
+              <Children>
+                <Container id="EFufMY_3G0KYfhC8uWox3Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="UukIXw8csUqYdKqWZbAc-w" name="Mass transfer rate (intestine to mucosa blood cells)" description="Mass transfer rate (intestine to mucosa blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="zc-z__JGpk2IpJnqbvTzxQ" isDefault="1" displayUnit="µmol/min">
+                      <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                    </Parameter>
+                  </Children>
+                </Container>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="vJoaAuJTX02Sv89mTqcrbQ" name="SmallIntestine_pls_UpperIleum_pls" description="Neighborhood between Small Intestine/Plasma_ and Upper Ileum/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="7uENbPvU7kOunFwGm9NtzA" secondNeighbor="ExfgzEZMLEKihI9r6OGmqA">
+              <Tags>
+                <Tag value="Neighborhood: Plasma / Plasma" />
+              </Tags>
+              <Children>
+                <Container id="ym6_4bj1HkC4RYuPd_clDg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="a-lKQKe2cEWiEqp-JguoVQ" name="Mass transfer rate (intestine to mucosa plasma)" description="Mass transfer rate (intestine to mucosa plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="qIfhIqP5eEqwyfjkWwy98Q" isDefault="1" displayUnit="µmol/min">
+                      <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                    </Parameter>
+                  </Children>
+                </Container>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="2UPVudA_P02Dg_as1DcfWQ" name="SmallIntestine_bc_UpperIleum_bc" description="Neighborhood between Small Intestine/Blood Cells_ and Upper Ileum/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="E0vWo0BDME6DiS7jT6IlYg" secondNeighbor="r0WtY-vx3UWxfs1sK8Zxcg">
+              <Tags>
+                <Tag value="Neighborhood: BloodCells / BloodCells" />
+              </Tags>
+              <Children>
+                <Container id="jwpWH-7TKUCtkv1NeoJYkg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="yZkFJd8RZ0mEMZUONQBwpA" name="Mass transfer rate (intestine to mucosa blood cells)" description="Mass transfer rate (intestine to mucosa blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="zc-z__JGpk2IpJnqbvTzxQ" isDefault="1" displayUnit="µmol/min">
+                      <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                    </Parameter>
+                  </Children>
+                </Container>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="vlql-FIzL06xoqYNBJu8Vg" name="Lumen_lil_LowerIleum_pls" description="Neighborhood between Lumen/Lower Ileum and Mucosa/Lower Ileum/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="wen_VH77NE2ORWa-gn7jMw" secondNeighbor="VAgy9eJ0pEWBUkCbQwloUw">
+              <Tags>
+                <Tag value="Neighborhood: LowerIleum / Plasma" />
+              </Tags>
+              <Children>
+                <Container id="Qt04mrWQ90a1dftuWUXL7g" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="97cKzbM-MkCeRjcGeC1uTQ" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="uKzg5qsit06VAeEp5xibnA" isDefault="1" displayUnit="µmol/min">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                    </Parameter>
+                    <Parameter id="u9sJ7QnoTkuTJSTZ6DJYAw" name="Sum of active process rates" description="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="5sKqjuv3WE2Nr_cTaUCUkQ" isDefault="1" displayUnit="µmol/min">
+                      <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                    </Parameter>
+                    <Parameter id="uBVkB_d9Akemvy6JOqRkZQ" name="Sum of passive process rates" description="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="CxnCjO7-kUCjpt84KomgXw" isDefault="1" displayUnit="µmol/min">
+                      <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                    </Parameter>
+                  </Children>
+                </Container>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="lRGqhuzWJkCPBhcY2nrA3w" name="Lumen_lil_LowerIleum_cell" description="Neighborhood between Lumen/Lower Ileum and Mucosa/Lower Ileum/Intracellular" mode="Logical" containerType="Neighborhood" firstNeighbor="wen_VH77NE2ORWa-gn7jMw" secondNeighbor="0vcKW7cWtU23dRVwq49IaA">
+              <Tags>
+                <Tag value="Neighborhood: LowerIleum / Intracellular" />
+              </Tags>
+              <Children>
+                <Container id="zBiKuYzZ0kCFleZkBMSi1w" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="t-fDmfTpU0uwIQheZE-_TQ" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="q0YooqvoU0qrUqycI7T_vw" isDefault="1" displayUnit="µmol/min">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                    </Parameter>
+                    <Parameter id="070n-SW6SkmRTfx2cRfVvQ" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="2vtZBgPdHESzFsyX5jWdxw" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="hBA8QnEPZ068yFQrT-a0YQ" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="J07S_NBj0kuLL902KgFuKg" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="TAWixPrFnE--lYHcq4cWgw" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Je8eB1IWckW3s8WiJf8JWg" isDefault="1">
+                      <Info min="0" flag="36" seq="1" ref="0" bb="2" group="67" />
+                    </Parameter>
+                    <Parameter id="u-G9sl9mVEqwNzm6ra7mxw" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CN9qX9dxzk-oukufQTDYaA" isDefault="1">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+                    </Parameter>
+                    <Parameter id="f7IQykTiNE-qzYhatzPJlA" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="0acefClmxUSAhyraL0v7UA" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="17hhQCzxV0WvV9aNpddZvg" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="El15YtuX6keaW1PAleyuBQ" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="jwHpjQVkE06Yks3u1v9YYA" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="27eSzHkQ3Umh5UZeqHG6aQ" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="aSeX1TV3REamgEXE_ivEkQ" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="MFpVdInbNE-cKxWJrXVfXA" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="jypSN_z6BkWZEXY1Ws5Ktw" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="0b4LjT2SYkCetYN153ppjQ" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="fqMN_dx_yU2JHBMqP7iiTQ" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="YzJvRkHMtUeiQyO2fhP81g" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="FOC3MDfxXkW0ZE6sBGj0yw" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Ap07gK_0Pk-62qv7f9OnrQ" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="E4hl4LNUikOI55VFBfv_lg" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="nVfYZ66FF0W84y9RBYsn8g" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="I9eTmNp9akSyyFecnwjI8A" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="gVsmm42vjUCp5xgwTI9NtA" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="sGHOe_hLrEeK-jhHFFrdmA" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="tE3kbrj5vEq-h8ChtOQtHA" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="gmjKizAog0yTaqaUn0wydw" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="4dKbSKIcqEOpuVa3g3kiFA" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
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+                    <Parameter id="ow_dvhqUFkeabAN-0vP9Vw" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Yqc1pqXfwUu4RTTUuBnOMw" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="o8h-5Ku2KE283qB6sRBgcw" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="kNxHC5F-a0SRE5tzNBa5Tw" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="I4tGgRsHFE-zbXweEM8fCg" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="o3bt8HMD8k-qhDrXNRJPKw" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="6HYjp3vxjU2MzV67h3gc7A" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="WBNyhWEmyEq682ssPupytg" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="xPaVgX-qe06ekfbA5b4vFQ" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="hfJ8fmA9TU-M1chssktruQ" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="hc_kW-SZgkKL4c91_mITYw" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="JAt57xHu6068UYo-USk-CQ" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="skUhud5VSkOQ5S3a7FRKlA" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CIta8XEcZ0-vg6OK2e7YMg" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="J_vZNbDrv06KBmceNs6CZg" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ggTKHPU3-ESxtInpiqhz0Q" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="boQWclkS3UmJ_F4Bf-ey-A" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TIMTClcjEkWa2Jrpm18ahQ" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="uU0YCOM2Mkmw7EvpJvRs9A" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="OSp6wupiGUm1ZDNcKvvKkA" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="GNxSXZEqJ06waQoFjfnrEQ" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="QGKMNC3BIU-L8isldgY-8A" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="0JrXxd3F4kSr3C1dgawj-Q" name="Sum of active process rates" description="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="5sKqjuv3WE2Nr_cTaUCUkQ" isDefault="1" displayUnit="µmol/min">
+                      <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                    </Parameter>
+                    <Parameter id="bSJQUKljvEe6UtdVBtbh6Q" name="Sum of passive process rates" description="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="CxnCjO7-kUCjpt84KomgXw" isDefault="1" displayUnit="µmol/min">
+                      <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                    </Parameter>
+                  </Children>
+                </Container>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="y5XyXjQYp06ZLuPbwuJBlA" name="SmallIntestine_pls_LowerIleum_pls" description="Neighborhood between Small Intestine/Plasma_ and Lower Ileum/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="7uENbPvU7kOunFwGm9NtzA" secondNeighbor="VAgy9eJ0pEWBUkCbQwloUw">
+              <Tags>
+                <Tag value="Neighborhood: Plasma / Plasma" />
+              </Tags>
+              <Children>
+                <Container id="4F8TyEZeUEqyayyC-obUbA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="WNUfJVYEfkK4IB0YVwWbcg" name="Mass transfer rate (intestine to mucosa plasma)" description="Mass transfer rate (intestine to mucosa plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="qIfhIqP5eEqwyfjkWwy98Q" isDefault="1" displayUnit="µmol/min">
+                      <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
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+                    <Parameter id="SA7Ktk3T_Een-fZov3E1kQ" name="Mass transfer rate (intestine to mucosa plasma)" description="Mass transfer rate (intestine to mucosa plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="qIfhIqP5eEqwyfjkWwy98Q" isDefault="1" displayUnit="µmol/min">
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+            <NeighborhoodBuilder id="TcZ9vfmSV0OlZO37Q4g5GA" name="LargeIntestine_bc_ColonDescendens_bc" description="Neighborhood between Large Intestine/Blood Cells_ and Colon Descendens/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="wsEjCxUbhEew0Q0BivassA" secondNeighbor="b1XobftQwUiN9-8v8K-ffA">
+              <Tags>
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+                    <Parameter id="AhJYgW-9KEqTzox7PJu13g" name="Mass transfer rate (intestine to mucosa blood cells)" description="Mass transfer rate (intestine to mucosa blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="zc-z__JGpk2IpJnqbvTzxQ" isDefault="1" displayUnit="µmol/min">
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+            <NeighborhoodBuilder id="pPnOQlnLFEuHMCYqMBcwIw" name="LargeIntestine_pls_ColonSigmoid_pls" description="Neighborhood between Large Intestine/Plasma_ and Colon Sigmoid/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="yOFV-yMQV0u3LENWNLEw4w" secondNeighbor="NnYDxAvR50id6cKL1JK05A">
+              <Tags>
+                <Tag value="Neighborhood: Plasma / Plasma" />
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+                <Container id="ol6iPBZhrUWczBSr0iEf8g" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
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+                    <Parameter id="WOywk3wBi0KwSauAHv3zag" name="Mass transfer rate (intestine to mucosa plasma)" description="Mass transfer rate (intestine to mucosa plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="qIfhIqP5eEqwyfjkWwy98Q" isDefault="1" displayUnit="µmol/min">
+                      <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
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+            <NeighborhoodBuilder id="wQHIwuziQkiNBtvCnR0rpQ" name="LargeIntestine_bc_ColonSigmoid_bc" description="Neighborhood between Large Intestine/Blood Cells_ and Colon Sigmoid/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="wsEjCxUbhEew0Q0BivassA" secondNeighbor="9rh5uMJZKkCrCkUcs7GNfA">
+              <Tags>
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+                <Container id="Wx5sL4ZyWkW8euhKTyJADg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
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+                    <Parameter id="7NZ8vCdPJUK5WtgwJb9vZw" name="Mass transfer rate (intestine to mucosa blood cells)" description="Mass transfer rate (intestine to mucosa blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="zc-z__JGpk2IpJnqbvTzxQ" isDefault="1" displayUnit="µmol/min">
+                      <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
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+            <NeighborhoodBuilder id="3LJ-posHlUOAU2S7-41-tA" name="LargeIntestine_pls_Rectum_pls" description="Neighborhood between Large Intestine/Plasma_ and Rectum/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="yOFV-yMQV0u3LENWNLEw4w" secondNeighbor="gR3w3fNA-kyAJ2dbxne0lw">
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+                <Container id="Gzia92Zrv0OVd9gpjTAwDg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
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+                <Container id="WijfFc7SJUS3tcvTDATn2g" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
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+                    <Tag value="Neighborhood: Plasma / BloodCells" />
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+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="pAXNhvjRnkG2lGKbQIPTqw" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="LFxvD31Yj0GGjFItDGX_mg" isDefault="1">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="69" />
+                    </Parameter>
+                    <Parameter id="uZ70IZRemkGffGusXaY9Kg" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="AGiWTt8CvEmeuesoKmPNgw" isDefault="1">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+                    </Parameter>
+                  </Children>
+                </Container>
+                <Parameter id="UdwyT0CfDkWuu8v4DEcBzw" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="mJOlP-5JSUugXTNxUGY-ww" isDefault="1" displayUnit="cm²">
+                  <Tags>
+                    <Tag value="Neighborhood: Interstitial / Intracellular" />
+                  </Tags>
+                  <Info min="0" flag="62" seq="10" ref="0" bb="32" group="105" />
+                </Parameter>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="b9WNf0UAvEqGZVaT_K0Hyg" name="Pericentral_pls_Pericentral_bc" description="Neighborhood between Liver/Pericentral/Plasma and Liver/Pericentral/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="4ON-uIC2yka_hwoIl3K68w" secondNeighbor="5bZh8mQG10-PXIrw1ZTguw">
+              <Tags>
+                <Tag value="Neighborhood: Plasma / BloodCells" />
+              </Tags>
+              <Children>
+                <Container id="kPRRc2iAM0WCNm0hnHJAhw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+                <Parameter id="laTASLttPUu2S84rt-hKwg" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="9dd2ygRzU02wgsSlWWXoZQ" isDefault="1" displayUnit="cm²">
+                  <Tags>
+                    <Tag value="Neighborhood: Plasma / BloodCells" />
+                  </Tags>
+                  <Info min="0" flag="62" seq="12" ref="0" bb="32" group="104" />
+                </Parameter>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="QAdxyJjGWUiBJhisOztwZA" name="Pericentral_pls_Pericentral_int" description="Neighborhood between Liver/Pericentral/Plasma and Liver/Pericentral/Interstitial" mode="Logical" containerType="Neighborhood" firstNeighbor="4ON-uIC2yka_hwoIl3K68w" secondNeighbor="OGrw2W605U2rhhi3U_alow">
+              <Tags>
+                <Tag value="Neighborhood: Plasma / Interstitial" />
+              </Tags>
+              <Children>
+                <Container id="AbZKxP4BU0S3Z0gZ1RLIjQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="YC1MxfuM90StGqB5Ba0ebg" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
+                      <ValueOrigin id="49" source="Other" method="Assumption" description="Assumption: very fast exchange" />
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="77" />
+                    </Parameter>
+                    <Parameter id="luAIFmDgDUifotb_gwvqwg" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="iKUspopJzEClLaOxGRLgvw" isDefault="1">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="70" />
+                    </Parameter>
+                  </Children>
+                </Container>
+                <Parameter id="b3QxHCYQBEmGGMA-D9FgBQ" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="UZbqyBbb902joHFZE9nR9Q" isDefault="1" displayUnit="cm²">
+                  <Tags>
+                    <Tag value="Neighborhood: Plasma / Interstitial" />
+                  </Tags>
+                  <Info min="0" flag="62" seq="10" ref="0" bb="32" group="106" />
+                </Parameter>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="UibYRyz3hE2RpWqcVUPq3Q" name="Lung_bc_ArterialBlood_bc" description="Neighborhood between Lung/Blood Cells and Arterial Blood/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="4-BftgHXdUGy3Tm3_NV1kA" secondNeighbor="bE0VJ8a31Uyaciw1C0jzTg">
+              <Tags>
+                <Tag value="Neighborhood: BloodCells / BloodCells" />
+              </Tags>
+              <Children>
+                <Container id="75CVi4ncSE-AJyGJWTafXQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="e42JtwGWQE-pRE5A0KmpjQ" name="Lung_int_Lung_cell" description="Neighborhood between Lung/Interstitial and Lung/Intracellular" mode="Logical" containerType="Neighborhood" firstNeighbor="9ckZpDyMwk6AKCwClTHdIw" secondNeighbor="1NzsX0eh2kKlC_xJpZEnJw">
+              <Tags>
+                <Tag value="Neighborhood: Interstitial / Intracellular" />
+              </Tags>
+              <Children>
+                <Container id="gnOGd2DSs02ENwtHzDmofQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="Z_-u_gdYeU-S4UArBl79aw" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="pn4TOZacr0GWHd9xAwFj8g" isDefault="1" displayUnit="cm/min">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="78" />
+                    </Parameter>
+                    <Parameter id="FHm3PVHm6EWsLG1GcdpeKA" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="QkTJVxVP3Ee97Zuh3Lg62w" isDefault="1" displayUnit="cm/min">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="76" />
+                    </Parameter>
+                    <Parameter id="TeNBJZPo70GnB9p_NPdaqg" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="SZrmcd1JDEW6MIjlHsCCew" isDefault="1" displayUnit="l/min">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="GnV1xngkO0-OFG8_7dbJhQ" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="y659fcMlZEKHrLpFwmHmIw" isDefault="1" displayUnit="l/min">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="69rzqodE_UWeGk51WAGnNQ" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="UgZ8q0MWoUqtJhxPStVohw" isDefault="1">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="ZuYY5CBEUECGs3wzuTuTPA" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="UgZ8q0MWoUqtJhxPStVohw" isDefault="1">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="aUoD_3gSnUSYAvwzkBPFyQ" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="LFxvD31Yj0GGjFItDGX_mg" isDefault="1">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="69" />
+                    </Parameter>
+                    <Parameter id="cu16GloBJU2HXvZpzQxwVQ" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="AGiWTt8CvEmeuesoKmPNgw" isDefault="1">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+                    </Parameter>
+                  </Children>
+                </Container>
+                <Parameter id="rh29UsJUHUq43tVfvHetSQ" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="fyqJbzL8-kqsR30BYqkXrg" isDefault="1" displayUnit="cm²">
+                  <Tags>
+                    <Tag value="Neighborhood: Interstitial / Intracellular" />
+                  </Tags>
+                  <Info min="0" flag="122" seq="11" ref="0" bb="32" group="105" />
+                </Parameter>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="IY4k3QxFuEGJCXvhcvS-nA" name="Lung_pls_ArterialBlood_pls" description="Neighborhood between Lung/Plasma and Arterial Blood/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="ZZhPPTmN4UK9ZYEZpa3LFg" secondNeighbor="Hl-Gd6HA30OOrhWd5UIAVQ">
+              <Tags>
+                <Tag value="Neighborhood: Plasma / Plasma" />
+              </Tags>
+              <Children>
+                <Container id="OvQ1lZnAukefEheajSjBGw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="_UNv3ng8XEON3--rZLqwOg" name="Lung_pls_Lung_bc" description="Neighborhood between Lung/Plasma and Lung/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="ZZhPPTmN4UK9ZYEZpa3LFg" secondNeighbor="4-BftgHXdUGy3Tm3_NV1kA">
+              <Tags>
+                <Tag value="Neighborhood: Plasma / BloodCells" />
+              </Tags>
+              <Children>
+                <Container id="0TH1QpsDCUq3KcQHP7ofLQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+                <Parameter id="yNrkeVyJM0-HKqFhSK27QQ" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="xH6OXEC65ESnPJ2unASWQA" isDefault="1" displayUnit="cm²">
+                  <Tags>
+                    <Tag value="Neighborhood: Plasma / BloodCells" />
+                  </Tags>
+                  <Info min="0" flag="122" seq="13" ref="0" bb="32" group="104" />
+                </Parameter>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="TODdQ-cEpEKFb1CjvTh_cw" name="Lung_pls_Lung_int" description="Neighborhood between Lung/Plasma and Lung/Interstitial" mode="Logical" containerType="Neighborhood" firstNeighbor="ZZhPPTmN4UK9ZYEZpa3LFg" secondNeighbor="9ckZpDyMwk6AKCwClTHdIw">
+              <Tags>
+                <Tag value="Neighborhood: Plasma / Interstitial" />
+              </Tags>
+              <Children>
+                <Container id="PChL0w-tLkmOh0HrfYZ5GA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="mV95JDHpQk-y_d0HQnxZ7A" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
+                      <ValueOrigin id="49" source="Other" method="Assumption" description="Assumption: very fast exchange" />
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="77" />
+                    </Parameter>
+                    <Parameter id="n4q4xDW90EKvFQCdjmDz8A" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="iKUspopJzEClLaOxGRLgvw" isDefault="1">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="70" />
+                    </Parameter>
+                  </Children>
+                </Container>
+                <Parameter id="flAcB1USXUStXnb7e1a96w" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="YX57qmODbU-M9-4csS_AyA" isDefault="1" displayUnit="cm²">
+                  <Tags>
+                    <Tag value="Neighborhood: Plasma / Interstitial" />
+                  </Tags>
+                  <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                  <Info min="0" flag="122" seq="11" ref="0" bb="32" group="106" />
+                </Parameter>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="WQvj0EskhkCU6hmNWb7ZIw" name="Muscle_bc_VenousBlood_bc" description="Neighborhood between Muscle/Blood Cells and Venous Blood/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="79ZV95ZikEqUvwM-RF-COg" secondNeighbor="Psihdre1OUqL7biUDEcQDw">
+              <Tags>
+                <Tag value="Neighborhood: BloodCells / BloodCells" />
+              </Tags>
+              <Children>
+                <Container id="EZjwtrgwk0iaf-c8SA9KUg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="iVzB6YERs0umc65fP77f0Q" name="Muscle_int_Muscle_cell" description="Neighborhood between Muscle/Interstitial and Muscle/Intracellular" mode="Logical" containerType="Neighborhood" firstNeighbor="LhvDbOn0kUiDCeTB3tKnLw" secondNeighbor="a2F1U1ZEMU6sCT9rH_ZO-w">
+              <Tags>
+                <Tag value="Neighborhood: Interstitial / Intracellular" />
+              </Tags>
+              <Children>
+                <Container id="8ieJL9yKKUuy0iOPFbmGjw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="IOLTuo-_I06N-qrOYfn5Ww" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="pn4TOZacr0GWHd9xAwFj8g" isDefault="1" displayUnit="cm/min">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="78" />
+                    </Parameter>
+                    <Parameter id="tMaeoikM7UybFOTBn3YY-Q" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="QkTJVxVP3Ee97Zuh3Lg62w" isDefault="1" displayUnit="cm/min">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="76" />
+                    </Parameter>
+                    <Parameter id="FKu0lKEMwUKskll8DId7BQ" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="SZrmcd1JDEW6MIjlHsCCew" isDefault="1" displayUnit="l/min">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="0xnUOmoxCk-YRZvqEtf0Ng" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="y659fcMlZEKHrLpFwmHmIw" isDefault="1" displayUnit="l/min">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="pXDfjQlFc0iM7kK-EuBhEQ" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="UgZ8q0MWoUqtJhxPStVohw" isDefault="1">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="AFyG4_OJrEyfwg28rRmbCg" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="UgZ8q0MWoUqtJhxPStVohw" isDefault="1">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="X4PeNpsUrEiH_HydxFWHiQ" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="LFxvD31Yj0GGjFItDGX_mg" isDefault="1">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="69" />
+                    </Parameter>
+                    <Parameter id="EJzuR62dzEuTB2ZmEE_DPA" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="AGiWTt8CvEmeuesoKmPNgw" isDefault="1">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+                    </Parameter>
+                  </Children>
+                </Container>
+                <Parameter id="A9QGQ_vrQUqdp8PrHs5oRg" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="R02yhvoiskOrS6HS6Qwpcw" isDefault="1" displayUnit="cm²">
+                  <Tags>
+                    <Tag value="Neighborhood: Interstitial / Intracellular" />
+                  </Tags>
+                  <Info min="0" flag="122" seq="12" ref="0" bb="32" group="105" />
+                </Parameter>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="ZUrLr0l22kuOsUss2CQYXA" name="Muscle_pls_Muscle_bc" description="Neighborhood between Muscle/Plasma and Muscle/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="_MamKH2EmEu_zsln6IKUnQ" secondNeighbor="79ZV95ZikEqUvwM-RF-COg">
+              <Tags>
+                <Tag value="Neighborhood: Plasma / BloodCells" />
+              </Tags>
+              <Children>
+                <Container id="x6-OqGN4AEWowRNcskolOw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+                <Parameter id="A3eo5lT5f0aNeOJoTABxMg" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="xH6OXEC65ESnPJ2unASWQA" isDefault="1" displayUnit="cm²">
+                  <Tags>
+                    <Tag value="Neighborhood: Plasma / BloodCells" />
+                  </Tags>
+                  <Info min="0" flag="122" seq="14" ref="0" bb="32" group="104" />
+                </Parameter>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="zC49wGHfdU2V5hKw1CA46A" name="Muscle_pls_Muscle_int" description="Neighborhood between Muscle/Plasma and Muscle/Interstitial" mode="Logical" containerType="Neighborhood" firstNeighbor="_MamKH2EmEu_zsln6IKUnQ" secondNeighbor="LhvDbOn0kUiDCeTB3tKnLw">
+              <Tags>
+                <Tag value="Neighborhood: Plasma / Interstitial" />
+              </Tags>
+              <Children>
+                <Container id="T_Um-FReUUOAxAVaIIqp6Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="Lv4iyC8uJES7EjIB8SUBmw" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
+                      <ValueOrigin id="49" source="Other" method="Assumption" description="Assumption: very fast exchange" />
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="77" />
+                    </Parameter>
+                    <Parameter id="ae15enFAC0CeENoxVdjPFQ" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="iKUspopJzEClLaOxGRLgvw" isDefault="1">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="70" />
+                    </Parameter>
+                  </Children>
+                </Container>
+                <Parameter id="vA4XmaR1WEarUs6uTYTp-Q" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="YX57qmODbU-M9-4csS_AyA" isDefault="1" displayUnit="cm²">
+                  <Tags>
+                    <Tag value="Neighborhood: Plasma / Interstitial" />
+                  </Tags>
+                  <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                  <Info min="0" flag="122" seq="12" ref="0" bb="32" group="106" />
+                </Parameter>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="-ByyBqGAhEeo86Zot8OXdw" name="Muscle_pls_VenousBlood_pls" description="Neighborhood between Muscle/Plasma and Venous Blood/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="_MamKH2EmEu_zsln6IKUnQ" secondNeighbor="OW9eeGpb1Ui7R75zcOETVQ">
+              <Tags>
+                <Tag value="Neighborhood: Plasma / Plasma" />
+              </Tags>
+              <Children>
+                <Container id="Ios8Zw-TMUW6S1hgAD2ykg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="_m_Ll8GqWUC6yWKBlZeyZQ" name="Pancreas_bc_PortalVein_bc" description="Neighborhood between Pancreas/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="rBmONNF-9U-E114Fh8WruQ" secondNeighbor="KB1_4NK_sU6lDGk5n9VoOQ">
+              <Tags>
+                <Tag value="Neighborhood: BloodCells / BloodCells" />
+              </Tags>
+              <Children>
+                <Container id="pV6ySJwDjEKsLqqvoLAdTg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="9aPVMvSAfES8JDy8lDO3gw" name="Pancreas_int_Pancreas_cell" description="Neighborhood between Pancreas/Interstitial and Pancreas/Intracellular" mode="Logical" containerType="Neighborhood" firstNeighbor="d9leJK1DNESWcTk1thvpqg" secondNeighbor="0qO7HDJeR0C1HEzJhovYTw">
+              <Tags>
+                <Tag value="Neighborhood: Interstitial / Intracellular" />
+              </Tags>
+              <Children>
+                <Container id="GNxQFYnSQkqVDSKHqpsLGA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="tvIq1ggGGEO-KoSnpTUAxg" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="pn4TOZacr0GWHd9xAwFj8g" isDefault="1" displayUnit="cm/min">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="78" />
+                    </Parameter>
+                    <Parameter id="CAstxboTiUavH4GvRF06Jg" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="QkTJVxVP3Ee97Zuh3Lg62w" isDefault="1" displayUnit="cm/min">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="76" />
+                    </Parameter>
+                    <Parameter id="6D8tTUu4X0e83KClo78Bdg" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="SZrmcd1JDEW6MIjlHsCCew" isDefault="1" displayUnit="l/min">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="DbdFjrMTHEeJBTYp0y7NdA" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="y659fcMlZEKHrLpFwmHmIw" isDefault="1" displayUnit="l/min">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="eokaw2YZPUCAH7MzLh9TYg" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="UgZ8q0MWoUqtJhxPStVohw" isDefault="1">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="0GuGRWNLOk-zdS3j5JkUvA" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="UgZ8q0MWoUqtJhxPStVohw" isDefault="1">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="dFf8Vo3-UU66EIazwlOAGA" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="LFxvD31Yj0GGjFItDGX_mg" isDefault="1">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="69" />
+                    </Parameter>
+                    <Parameter id="7D1HN7MNp0aJvviVX94T-g" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="AGiWTt8CvEmeuesoKmPNgw" isDefault="1">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+                    </Parameter>
+                  </Children>
+                </Container>
+                <Parameter id="uGsShL8CckuSQKQajRfcUA" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="RCKEOKgoGU-bQzr56xEn5Q" isDefault="1" displayUnit="cm²">
+                  <Tags>
+                    <Tag value="Neighborhood: Interstitial / Intracellular" />
+                  </Tags>
+                  <Info min="0" flag="122" seq="13" ref="0" bb="32" group="105" />
+                </Parameter>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="xnMiJN1p8kO9KC3MxWoOLA" name="Pancreas_pls_Pancreas_bc" description="Neighborhood between Pancreas/Plasma and Pancreas/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="m5U8oucV-EO-_1sOC7LuFQ" secondNeighbor="rBmONNF-9U-E114Fh8WruQ">
+              <Tags>
+                <Tag value="Neighborhood: Plasma / BloodCells" />
+              </Tags>
+              <Children>
+                <Container id="h5_elf1rJEuOmtSyw6gcyQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+                <Parameter id="uBFAi8NAzEiNnZYD-AaurQ" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="xH6OXEC65ESnPJ2unASWQA" isDefault="1" displayUnit="cm²">
+                  <Tags>
+                    <Tag value="Neighborhood: Plasma / BloodCells" />
+                  </Tags>
+                  <Info min="0" flag="122" seq="15" ref="0" bb="32" group="104" />
+                </Parameter>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="fbdk1Or7Q0-RVPXLUV0_WQ" name="Pancreas_pls_Pancreas_int" description="Neighborhood between Pancreas/Plasma and Pancreas/Interstitial" mode="Logical" containerType="Neighborhood" firstNeighbor="m5U8oucV-EO-_1sOC7LuFQ" secondNeighbor="d9leJK1DNESWcTk1thvpqg">
+              <Tags>
+                <Tag value="Neighborhood: Plasma / Interstitial" />
+              </Tags>
+              <Children>
+                <Container id="Z6lo_I5nkEKDhHX17fJWnw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="hPNPN1OxxU2OYpDI4XKqQw" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
+                      <ValueOrigin id="49" source="Other" method="Assumption" description="Assumption: very fast exchange" />
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="77" />
+                    </Parameter>
+                    <Parameter id="B1hMEwu5rk25v9RDBPtngw" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="iKUspopJzEClLaOxGRLgvw" isDefault="1">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="70" />
+                    </Parameter>
+                  </Children>
+                </Container>
+                <Parameter id="QlrH5DRgNU6RKaTlGScFQw" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="YX57qmODbU-M9-4csS_AyA" isDefault="1" displayUnit="cm²">
+                  <Tags>
+                    <Tag value="Neighborhood: Plasma / Interstitial" />
+                  </Tags>
+                  <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                  <Info min="0" flag="122" seq="13" ref="0" bb="32" group="106" />
+                </Parameter>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="sjiTgDNNAUyFcMelBJNelA" name="Pancreas_pls_PortalVein_pls" description="Neighborhood between Pancreas/Plasma and PortalVein/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="m5U8oucV-EO-_1sOC7LuFQ" secondNeighbor="7wRB5qMJl0aPiDibnmji6g">
+              <Tags>
+                <Tag value="Neighborhood: Plasma / Plasma" />
+              </Tags>
+              <Children>
+                <Container id="NP_9WZpO60yL6IrwQjmphw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="cxnn6xqytkGJoAsAe2CBkQ" name="Lumen_rect_Rectum_pls" description="Neighborhood between Lumen/Rectum and Mucosa/Rectum/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="WXUsQpIjG0WT7kojm5PhDg" secondNeighbor="gR3w3fNA-kyAJ2dbxne0lw">
+              <Tags>
+                <Tag value="Neighborhood: Rectum / Plasma" />
+              </Tags>
+              <Children>
+                <Container id="8Rn7cl5Eok-u9q4BzpFeOA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="6uEUZotJx0epdKzXNO3JPQ" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="uKzg5qsit06VAeEp5xibnA" isDefault="1" displayUnit="µmol/min">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                    </Parameter>
+                    <Parameter id="JURa9i7w_k24fJT8fVN0rg" name="Sum of active process rates" description="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="5sKqjuv3WE2Nr_cTaUCUkQ" isDefault="1" displayUnit="µmol/min">
+                      <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                    </Parameter>
+                    <Parameter id="-AU58s-0-UWcA8fiCWplSg" name="Sum of passive process rates" description="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="CxnCjO7-kUCjpt84KomgXw" isDefault="1" displayUnit="µmol/min">
+                      <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                    </Parameter>
+                  </Children>
+                </Container>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="8uuQHqeuZ0CA0i9MCNJ7XQ" name="Lumen_rect_Rectum_cell" description="Neighborhood between Lumen/Rectum and Mucosa/Rectum/Intracellular" mode="Logical" containerType="Neighborhood" firstNeighbor="WXUsQpIjG0WT7kojm5PhDg" secondNeighbor="Rn97Mtjr40q020tADawIvg">
+              <Tags>
+                <Tag value="Neighborhood: Rectum / Intracellular" />
+              </Tags>
+              <Children>
+                <Container id="KPs_ZUGqhkqE7m4cbcDr6A" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="jIy7Pg8AkUiNs3QMBPAkxw" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="q0YooqvoU0qrUqycI7T_vw" isDefault="1" displayUnit="µmol/min">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                    </Parameter>
+                    <Parameter id="cphTqoU8wkmj9EDn9d0Ubg" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="2vtZBgPdHESzFsyX5jWdxw" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="EGkeCT12XUm_RTbYpGi-lw" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="J07S_NBj0kuLL902KgFuKg" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="j5Q4z0h9Xki5z4mifyLgCg" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ub8wK1jPEU-9zK32XCrdJA" isDefault="1">
+                      <Info min="0" flag="36" seq="1" ref="0" bb="2" group="67" />
+                    </Parameter>
+                    <Parameter id="ejeOF5MLA0CbejW47fUO_g" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="SR-4beBij0Wcja3x5w_jew" isDefault="1">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+                    </Parameter>
+                    <Parameter id="Ve60haG-c0eGhu5rhu2GxA" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="0acefClmxUSAhyraL0v7UA" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="FFhUdkzyIE2eHXdYg91TZw" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="El15YtuX6keaW1PAleyuBQ" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="dfFN2NlZFEC6cA9TuCasCA" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="27eSzHkQ3Umh5UZeqHG6aQ" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="lmy-1zZBkEGFm6NdgkpMyw" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="MFpVdInbNE-cKxWJrXVfXA" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="RZMzcRknq0CJE3NrGl564A" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="0b4LjT2SYkCetYN153ppjQ" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="T9mczFXUU0-9qTFMtDJFiw" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="YzJvRkHMtUeiQyO2fhP81g" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="f_v_d3b4CkKCczcSjl8jAQ" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Ap07gK_0Pk-62qv7f9OnrQ" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="2iZdQuylik2_S3jXFANGeQ" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="nVfYZ66FF0W84y9RBYsn8g" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="DA8cWW0Xe0aOWzxF5h95Sg" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="gVsmm42vjUCp5xgwTI9NtA" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="5XMdG_7GTUaagkQh96ZbPQ" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="tE3kbrj5vEq-h8ChtOQtHA" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="X-cwHwqa1kmwCJnsUMA45Q" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="4dKbSKIcqEOpuVa3g3kiFA" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="k9HagVrCAEKiwvcHDUaWNw" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Yqc1pqXfwUu4RTTUuBnOMw" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="y3CDPA3ERkq6jN-vH8Ds-g" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="kNxHC5F-a0SRE5tzNBa5Tw" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="0gBtPgqITE-GLsbci3bysQ" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="o3bt8HMD8k-qhDrXNRJPKw" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="PTfCtg6oz0y8GhkvF5YCOQ" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="WBNyhWEmyEq682ssPupytg" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="EqW3NAdCnUW3jwLGMJ-O4A" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="hfJ8fmA9TU-M1chssktruQ" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="FXiYPCW9VkqyqP3EhCuyRQ" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="JAt57xHu6068UYo-USk-CQ" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="XPbFhP_0e06y-2OJ69Qw2A" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CIta8XEcZ0-vg6OK2e7YMg" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="glafoNY4t0K-ZXsIqUHcCA" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ggTKHPU3-ESxtInpiqhz0Q" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="aI-EQEmiRka5gq3CHze6wA" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TIMTClcjEkWa2Jrpm18ahQ" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="Vwna4qkAKUa7jvt6en_Fpw" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="OSp6wupiGUm1ZDNcKvvKkA" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="M3VYelZV8UarWHvql1nM5Q" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="QGKMNC3BIU-L8isldgY-8A" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="eBqMBsr3R0Ox49tAHKlxbg" name="Sum of active process rates" description="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="5sKqjuv3WE2Nr_cTaUCUkQ" isDefault="1" displayUnit="µmol/min">
+                      <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                    </Parameter>
+                    <Parameter id="PnQwUEsn40KNkEW6jqJbtA" name="Sum of passive process rates" description="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="CxnCjO7-kUCjpt84KomgXw" isDefault="1" displayUnit="µmol/min">
+                      <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                    </Parameter>
+                  </Children>
+                </Container>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="oJauRHoZ6E-RU1m1wi87lQ" name="Rectum_pls_PortalVein_pls" description="Neighborhood between Rectum/Plasma and PortalVein/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="gR3w3fNA-kyAJ2dbxne0lw" secondNeighbor="7wRB5qMJl0aPiDibnmji6g">
+              <Tags>
+                <Tag value="Neighborhood: Plasma / Plasma" />
+              </Tags>
+              <Children>
+                <Container id="ZF52vAKQCUiT-SsafDMIUg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="AcMq9W-tTU6bAlRdA97x8g" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="XpzF09V4WECHn0Y8QxGOGA" isDefault="1" displayUnit="µmol/min">
+                      <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                    </Parameter>
+                  </Children>
+                </Container>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="LaPINz3yr0ivdVpNSJ4XEA" name="Rectum_bc_PortalVein_bc" description="Neighborhood between Rectum/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="mfre2X8CW0iMNT9dYG5xdg" secondNeighbor="KB1_4NK_sU6lDGk5n9VoOQ">
+              <Tags>
+                <Tag value="Neighborhood: BloodCells / BloodCells" />
+              </Tags>
+              <Children>
+                <Container id="f0LeSTmKJUq1sG1nHflxkg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="hAW9BERJ7UO6f7dNqg-VWQ" name="Mass transfer rate (mucosa to portal vein blood cells)" description="Mass transfer rate (mucosa to portal vein blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="8RqexjECt0iuSu_Ga-vZ2Q" isDefault="1" displayUnit="µmol/min">
+                      <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                    </Parameter>
+                  </Children>
+                </Container>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="I1sYfeYjj0C_U6XM5LYI_Q" name="PortalVein_pls_PortalVein_bc" description="Neighborhood between PortalVein/Plasma and PortalVein/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="7wRB5qMJl0aPiDibnmji6g" secondNeighbor="KB1_4NK_sU6lDGk5n9VoOQ">
+              <Tags>
+                <Tag value="Neighborhood: Plasma / BloodCells" />
+              </Tags>
+              <Children>
+                <Container id="g8sRxPoYOkCNGen2KBVjbQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+                <Parameter id="VHgpvuD8pkS_LpcvbFWMJA" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="MBpwdXYbNUiqS3uQZDhduw" isDefault="1" displayUnit="cm²">
+                  <Tags>
+                    <Tag value="Neighborhood: Plasma / BloodCells" />
+                  </Tags>
+                  <Info min="0" flag="122" seq="16" ref="0" bb="32" group="104" />
+                </Parameter>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="ii6YCOH__UCJKh4_K2wH-w" name="Skin_bc_VenousBlood_bc" description="Neighborhood between Skin/Blood Cells and Venous Blood/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="oEd7E3QlUUWulGR8Pf0DSQ" secondNeighbor="Psihdre1OUqL7biUDEcQDw">
+              <Tags>
+                <Tag value="Neighborhood: BloodCells / BloodCells" />
+              </Tags>
+              <Children>
+                <Container id="XmCi4bKXP0a5HNitwJnl7Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="Ugb50t10t0q2eZHH3sZAlg" name="Skin_int_Skin_cell" description="Neighborhood between Skin/Interstitial and Skin/Intracellular" mode="Logical" containerType="Neighborhood" firstNeighbor="7dC_SGmW_kaN81K7bvLkcg" secondNeighbor="G1XMPpe0UEqk1O3Pu-eGQg">
+              <Tags>
+                <Tag value="Neighborhood: Interstitial / Intracellular" />
+              </Tags>
+              <Children>
+                <Container id="c10tFjhhO0SV3Dq1WUZscw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="ePoPy_yHEkeXhexdEMeMDA" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="pn4TOZacr0GWHd9xAwFj8g" isDefault="1" displayUnit="cm/min">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="78" />
+                    </Parameter>
+                    <Parameter id="f1s-lyCJrE-DGQ4ferBZig" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="QkTJVxVP3Ee97Zuh3Lg62w" isDefault="1" displayUnit="cm/min">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="76" />
+                    </Parameter>
+                    <Parameter id="IlcplKPwIEitxK1p1E5Iwg" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="SZrmcd1JDEW6MIjlHsCCew" isDefault="1" displayUnit="l/min">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="YOsLzgHPDkyH7QmTvO94fg" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="y659fcMlZEKHrLpFwmHmIw" isDefault="1" displayUnit="l/min">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="1MBOfyG1W0SDkUQPdwd4oA" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="UgZ8q0MWoUqtJhxPStVohw" isDefault="1">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="fzY28aR5E0SYRXsSjWAZhA" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="UgZ8q0MWoUqtJhxPStVohw" isDefault="1">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="XjWJrCt9A0Ob1hFjVqnYzw" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="LFxvD31Yj0GGjFItDGX_mg" isDefault="1">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="69" />
+                    </Parameter>
+                    <Parameter id="vicHVcB5EEGmT0xQ5OG1lw" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="AGiWTt8CvEmeuesoKmPNgw" isDefault="1">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+                    </Parameter>
+                  </Children>
+                </Container>
+                <Parameter id="PnqhwHA5H0CHvO9ZUNvA6g" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="M8z5CbIzNEu_bANY-JbQjA" isDefault="1" displayUnit="cm²">
+                  <Tags>
+                    <Tag value="Neighborhood: Interstitial / Intracellular" />
+                  </Tags>
+                  <Info min="0" flag="122" seq="14" ref="0" bb="32" group="105" />
+                </Parameter>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="bSc6ia7noUieEcJpNRQbOg" name="Skin_pls_Skin_bc" description="Neighborhood between Skin/Plasma and Skin/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="eLnrUcbYMk6o07W_5SFa_A" secondNeighbor="oEd7E3QlUUWulGR8Pf0DSQ">
+              <Tags>
+                <Tag value="Neighborhood: Plasma / BloodCells" />
+              </Tags>
+              <Children>
+                <Container id="bGokJ9Afs0aUu4qK-ZA0pQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+                <Parameter id="afYHCEmBRU6EZzpDx9xUSQ" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="xH6OXEC65ESnPJ2unASWQA" isDefault="1" displayUnit="cm²">
+                  <Tags>
+                    <Tag value="Neighborhood: Plasma / BloodCells" />
+                  </Tags>
+                  <Info min="0" flag="122" seq="17" ref="0" bb="32" group="104" />
+                </Parameter>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="htbcbU5OIkuC8C-cq0_Xqw" name="Skin_pls_Skin_int" description="Neighborhood between Skin/Plasma and Skin/Interstitial" mode="Logical" containerType="Neighborhood" firstNeighbor="eLnrUcbYMk6o07W_5SFa_A" secondNeighbor="7dC_SGmW_kaN81K7bvLkcg">
+              <Tags>
+                <Tag value="Neighborhood: Plasma / Interstitial" />
+              </Tags>
+              <Children>
+                <Container id="uwpJCtTL8ECR-70HXL0HJg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="9nHDk1R2w0O3yEJMlhoJQQ" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
+                      <ValueOrigin id="49" source="Other" method="Assumption" description="Assumption: very fast exchange" />
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="77" />
+                    </Parameter>
+                    <Parameter id="De_chgR5akGkL7cLER5D1A" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="iKUspopJzEClLaOxGRLgvw" isDefault="1">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="70" />
+                    </Parameter>
+                  </Children>
+                </Container>
+                <Parameter id="ykQNt5txFEKTwn0lkGdA8g" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="YX57qmODbU-M9-4csS_AyA" isDefault="1" displayUnit="cm²">
+                  <Tags>
+                    <Tag value="Neighborhood: Plasma / Interstitial" />
+                  </Tags>
+                  <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                  <Info min="0" flag="122" seq="14" ref="0" bb="32" group="106" />
+                </Parameter>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="gyQKhXS0VUWpuCgGsSEwLA" name="Skin_pls_VenousBlood_pls" description="Neighborhood between Skin/Plasma and Venous Blood/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="eLnrUcbYMk6o07W_5SFa_A" secondNeighbor="OW9eeGpb1Ui7R75zcOETVQ">
+              <Tags>
+                <Tag value="Neighborhood: Plasma / Plasma" />
+              </Tags>
+              <Children>
+                <Container id="3LW5e0om_kqCrCssZn1oPw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="4VA7DQMrcUu7Su-v_IGzEQ" name="Spleen_bc_PortalVein_bc" description="Neighborhood between Spleen/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="M2WKAv8OrkawUNjTsjLgyg" secondNeighbor="KB1_4NK_sU6lDGk5n9VoOQ">
+              <Tags>
+                <Tag value="Neighborhood: BloodCells / BloodCells" />
+              </Tags>
+              <Children>
+                <Container id="bKDFjeS74EaKwbO_chQqBQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="zRU0-QjQ9UOBsXm4oofyxQ" name="Spleen_int_Spleen_cell" description="Neighborhood between Spleen/Interstitial and Spleen/Intracellular" mode="Logical" containerType="Neighborhood" firstNeighbor="2fraxtueHkm8lMM3fOiLXw" secondNeighbor="i1qACGojb0OWgiB4FLoxfQ">
+              <Tags>
+                <Tag value="Neighborhood: Interstitial / Intracellular" />
+              </Tags>
+              <Children>
+                <Container id="8A0CNVc2mkCD6a-E270grg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="4ggfMokOtUuy3u1yinotQg" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="pn4TOZacr0GWHd9xAwFj8g" isDefault="1" displayUnit="cm/min">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="78" />
+                    </Parameter>
+                    <Parameter id="dNAfIaP_5UGtasv_qfGMmg" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="QkTJVxVP3Ee97Zuh3Lg62w" isDefault="1" displayUnit="cm/min">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="76" />
+                    </Parameter>
+                    <Parameter id="EGpnhMCoME2PjrO9h6bNMQ" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="SZrmcd1JDEW6MIjlHsCCew" isDefault="1" displayUnit="l/min">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="YyHK-6e2Xk2fLXt_bwwV3g" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="y659fcMlZEKHrLpFwmHmIw" isDefault="1" displayUnit="l/min">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="pVoMcG_aNUaIk6idXQNwTw" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="UgZ8q0MWoUqtJhxPStVohw" isDefault="1">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="MfymuG-OsEmaryYs4Vo5Ng" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="UgZ8q0MWoUqtJhxPStVohw" isDefault="1">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="bT2pzr53IU666NVF4XNb3w" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="LFxvD31Yj0GGjFItDGX_mg" isDefault="1">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="69" />
+                    </Parameter>
+                    <Parameter id="uHIw-AgwnUqz3cl4trhFbw" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="AGiWTt8CvEmeuesoKmPNgw" isDefault="1">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+                    </Parameter>
+                  </Children>
+                </Container>
+                <Parameter id="mnLCM_1Cj02jmuR79pVpNw" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="V_8FhgpcLEyoqrRRXlMh-w" isDefault="1" displayUnit="cm²">
+                  <Tags>
+                    <Tag value="Neighborhood: Interstitial / Intracellular" />
+                  </Tags>
+                  <Info min="0" flag="122" seq="16" ref="0" bb="32" group="105" />
+                </Parameter>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="GZlZgOELTkitdpuH_mxd6w" name="Spleen_pls_PortalVein_pls" description="Neighborhood between Spleen/Plasma and PortalVein/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="b277qVHUMki37Y-xN7qKrQ" secondNeighbor="7wRB5qMJl0aPiDibnmji6g">
+              <Tags>
+                <Tag value="Neighborhood: Plasma / Plasma" />
+              </Tags>
+              <Children>
+                <Container id="Ao_LjWwpZ0SWVUe5-1MYiw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="DaYScs2-U0-U4F_v2_tEfA" name="Spleen_pls_Spleen_bc" description="Neighborhood between Spleen/Plasma and Spleen/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="b277qVHUMki37Y-xN7qKrQ" secondNeighbor="M2WKAv8OrkawUNjTsjLgyg">
+              <Tags>
+                <Tag value="Neighborhood: Plasma / BloodCells" />
+              </Tags>
+              <Children>
+                <Container id="EhuQrzLsGUq8dOSK5yTw9A" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+                <Parameter id="XwkEajb0NE-267sBNnkTZA" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="xH6OXEC65ESnPJ2unASWQA" isDefault="1" displayUnit="cm²">
+                  <Tags>
+                    <Tag value="Neighborhood: Plasma / BloodCells" />
+                  </Tags>
+                  <Info min="0" flag="122" seq="19" ref="0" bb="32" group="104" />
+                </Parameter>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="siYvtxtMHEWEFjI7tPpIFA" name="Spleen_pls_Spleen_int" description="Neighborhood between Spleen/Plasma and Spleen/Interstitial" mode="Logical" containerType="Neighborhood" firstNeighbor="b277qVHUMki37Y-xN7qKrQ" secondNeighbor="2fraxtueHkm8lMM3fOiLXw">
+              <Tags>
+                <Tag value="Neighborhood: Plasma / Interstitial" />
+              </Tags>
+              <Children>
+                <Container id="eog8Vam8GkOXZlKngtAglA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="lfVsPMd-kE66nGqofG6sMA" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
+                      <ValueOrigin id="49" source="Other" method="Assumption" description="Assumption: very fast exchange" />
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="77" />
+                    </Parameter>
+                    <Parameter id="_9txp99SI0iHWTXusyvbSw" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="iKUspopJzEClLaOxGRLgvw" isDefault="1">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="70" />
+                    </Parameter>
+                  </Children>
+                </Container>
+                <Parameter id="rpkXZs9FOUSC0P_jJpSPcw" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="YX57qmODbU-M9-4csS_AyA" isDefault="1" displayUnit="cm²">
+                  <Tags>
+                    <Tag value="Neighborhood: Plasma / Interstitial" />
+                  </Tags>
+                  <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                  <Info min="0" flag="122" seq="16" ref="0" bb="32" group="106" />
+                </Parameter>
+              </Children>
+            </NeighborhoodBuilder>
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+                <Tag value="Neighborhood: SalivaGland / Saliva" />
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+                <Container id="oAVnUtckMECm3DsvnPtm6g" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
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+                      <ValueOrigin id="43" source="Internet" description="Willi Cawello. Pharmacokinetics and bioavailability derived from various body fluids. http://www.agah.eu/fileadmin/_migrated/content_uploads/W._Cawello__2__25.05.07.pdf" />
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="69" />
+                    </Parameter>
+                    <Parameter id="xfmIR8kGwUuZEcAyW0g-tA" name="SalivaPlasmaRatio" description="Ratio of saliva vs. plasma concentrations" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="QCZGq05qgEWrku5ohYUPmw" isDefault="1">
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+                <Tag value="Neighborhood: Interstitial / Intracellular" />
+                <Tag value="Small intestine  neighborhood" />
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+                <Container id="GRpeKbp_jUqV5ZQkJZbxAA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
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+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
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+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
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+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
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+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
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+                    <Parameter id="dvyZpqS5oUu61MJgsjluLw" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="LFxvD31Yj0GGjFItDGX_mg" isDefault="1">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="147" />
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+                    <Parameter id="0Z6facyvN0iCNly2y3kTvQ" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="AGiWTt8CvEmeuesoKmPNgw" isDefault="1">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
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+                <Parameter id="CLyn38E5NkmhQqvY2u2j6w" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="kKtQ1PFoz0OCyHhlywizOA" isDefault="1" displayUnit="cm²">
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+                    <Tag value="Neighborhood: Interstitial / Intracellular" />
+                    <Tag value="Small intestine  neighborhood" />
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+                  <Tags>
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+                    <Tag value="Small intestine  neighborhood" />
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+                  <Info min="0" flag="122" seq="21" ref="0" bb="32" group="104" />
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+                <Tag value="Small intestine  neighborhood" />
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+                <Container id="YckBopehlUyiJaKasSebQQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
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+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
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+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="147" />
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+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
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+                    <Tag value="Small intestine  neighborhood" />
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+                  <Info min="0" flag="122" seq="19" ref="0" bb="32" group="105" />
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+                <Tag value="Small intestine  neighborhood" />
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+                  <Tags>
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+                <Tag value="Neighborhood: Interstitial / Intracellular" />
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+                <Container id="elE2bBwjqESrP4rq2pvduQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
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+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="133" />
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+                    <Parameter id="GD4mvF3SsUyDPE-ZKiIaDA" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="SZrmcd1JDEW6MIjlHsCCew" isDefault="1" displayUnit="l/min">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
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+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
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+                    <Parameter id="-YDwzowh9kS1lksgZc2Esg" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="UgZ8q0MWoUqtJhxPStVohw" isDefault="1">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
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+                    <Parameter id="lPDoItyEOkCzKE8R8JCuCg" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="UgZ8q0MWoUqtJhxPStVohw" isDefault="1">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
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+                    <Parameter id="ER6kXTZtCUyHG4gXuVlEgQ" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="LFxvD31Yj0GGjFItDGX_mg" isDefault="1">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="147" />
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+                    <Parameter id="58NYQ7B28kqFHncn-Q-4ww" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="AGiWTt8CvEmeuesoKmPNgw" isDefault="1">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
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+                  <Tags>
+                    <Tag value="Neighborhood: Interstitial / Intracellular" />
+                    <Tag value="Small intestine  neighborhood" />
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+                  <Info min="0" flag="122" seq="20" ref="0" bb="32" group="105" />
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+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="8_lWlOj0-kaCAOuDvLlUSw" name="LowerJejunum_pls_LowerJejunum_bc" description="Neighborhood between Small Intestine/Mucosa/Lower Jejunum/Plasma and Small Intestine/Mucosa/Lower Jejunum/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="s7paVHLpgU-ARIQEjrTkow" secondNeighbor="VukDQ4kjKEK6n1m_HO3RKg">
+              <Tags>
+                <Tag value="Neighborhood: Plasma / BloodCells" />
+                <Tag value="Small intestine  neighborhood" />
+              </Tags>
+              <Children>
+                <Container id="I6o0EyOdtUmQZc8ZLAy3rA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+                <Parameter id="QAxqL3yglUKyEFoySCzR-Q" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="xH6OXEC65ESnPJ2unASWQA" isDefault="1" displayUnit="cm²">
+                  <Tags>
+                    <Tag value="Neighborhood: Plasma / BloodCells" />
+                    <Tag value="Small intestine  neighborhood" />
+                  </Tags>
+                  <Info min="0" flag="122" seq="23" ref="0" bb="32" group="104" />
+                </Parameter>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="uNcC4Go_OUS4a2glZzQDtw" name="LowerJejunum_pls_LowerJejunum_int" description="Neighborhood between Small Intestine/Mucosa/Lower Jejunum/Plasma and Small Intestine/Mucosa/Lower Jejunum/Interstitial" mode="Logical" containerType="Neighborhood" firstNeighbor="s7paVHLpgU-ARIQEjrTkow" secondNeighbor="Q4E86CQOH0K7uQpKh7V0fA">
+              <Tags>
+                <Tag value="Neighborhood: Plasma / Interstitial" />
+                <Tag value="Small intestine  neighborhood" />
+              </Tags>
+              <Children>
+                <Container id="hDXmsBW_S06JB6BcPGxweA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="mF5Ez0SJSUylAHlbSCJorQ" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
+                      <ValueOrigin id="49" source="Other" method="Assumption" description="Assumption: very fast exchange" />
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="134" />
+                    </Parameter>
+                    <Parameter id="HtRCGFldv0-3H5BXKJksCA" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="iKUspopJzEClLaOxGRLgvw" isDefault="1">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="148" />
+                    </Parameter>
+                  </Children>
+                </Container>
+                <Parameter id="9cWowut2_0-b2_mWcDxArQ" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="YX57qmODbU-M9-4csS_AyA" isDefault="1" displayUnit="cm²">
+                  <Tags>
+                    <Tag value="Neighborhood: Plasma / Interstitial" />
+                    <Tag value="Small intestine  neighborhood" />
+                  </Tags>
+                  <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                  <Info min="0" flag="122" seq="20" ref="0" bb="32" group="106" />
+                </Parameter>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="3K6bhgL4zkWxSig_aJ0o_w" name="UpperIleum_int_UpperIleum_cell" description="Neighborhood between Small Intestine/Mucosa/Upper Ileum/Interstitial and Small Intestine/Mucosa/Upper Ileum/Intracellular" mode="Logical" containerType="Neighborhood" firstNeighbor="8d23X9v4OUO6u2MqRJcTOA" secondNeighbor="L1bm6q9hXUaQWfjmYlWmTg">
+              <Tags>
+                <Tag value="Neighborhood: Interstitial / Intracellular" />
+                <Tag value="Small intestine  neighborhood" />
+              </Tags>
+              <Children>
+                <Container id="EdcAgucZ_06gOP86lUoD5g" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="DbZCt1dcP0-NmdrTXzEZ2A" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="BZvTAvj0WkmqeZtWTfgNdg" isDefault="1" displayUnit="cm/min">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="135" />
+                    </Parameter>
+                    <Parameter id="qZd-gXt6P06OAMajfI7y2Q" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="kVr36g4fqk6rVcAmgk03Gg" isDefault="1" displayUnit="cm/min">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="133" />
+                    </Parameter>
+                    <Parameter id="xawrG4SjLkmwIWqshgTdig" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="SZrmcd1JDEW6MIjlHsCCew" isDefault="1" displayUnit="l/min">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="6pvQ2lo88UOh28GjaV8kXw" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="y659fcMlZEKHrLpFwmHmIw" isDefault="1" displayUnit="l/min">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="7hcvkvdaGUiEigynLobSGw" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="UgZ8q0MWoUqtJhxPStVohw" isDefault="1">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="QDHFs4vuZECTkK9Rk5y6Rg" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="UgZ8q0MWoUqtJhxPStVohw" isDefault="1">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="EXjjqAEjskyxn_X1-7Fa5w" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="LFxvD31Yj0GGjFItDGX_mg" isDefault="1">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="147" />
+                    </Parameter>
+                    <Parameter id="UT46tifkP0KANUTEiQbdvQ" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="AGiWTt8CvEmeuesoKmPNgw" isDefault="1">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+                    </Parameter>
+                  </Children>
+                </Container>
+                <Parameter id="2BnsC4mwd0WnqUOLw3_yRQ" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="WPx8ZHNKakmzDlNLLc-vjw" isDefault="1" displayUnit="cm²">
+                  <Tags>
+                    <Tag value="Neighborhood: Interstitial / Intracellular" />
+                    <Tag value="Small intestine  neighborhood" />
+                  </Tags>
+                  <Info min="0" flag="122" seq="21" ref="0" bb="32" group="105" />
+                </Parameter>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="da3wP_Bx20mU2h1aKMx1WQ" name="UpperIleum_pls_UpperIleum_bc" description="Neighborhood between Small Intestine/Mucosa/Upper Ileum/Plasma and Small Intestine/Mucosa/Upper Ileum/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="ExfgzEZMLEKihI9r6OGmqA" secondNeighbor="r0WtY-vx3UWxfs1sK8Zxcg">
+              <Tags>
+                <Tag value="Neighborhood: Plasma / BloodCells" />
+                <Tag value="Small intestine  neighborhood" />
+              </Tags>
+              <Children>
+                <Container id="Q6eJyDahkUau-EbhBbRfjA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+                <Parameter id="0oL6pEZG40SrreNDLKrsxg" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="xH6OXEC65ESnPJ2unASWQA" isDefault="1" displayUnit="cm²">
+                  <Tags>
+                    <Tag value="Neighborhood: Plasma / BloodCells" />
+                    <Tag value="Small intestine  neighborhood" />
+                  </Tags>
+                  <Info min="0" flag="122" seq="24" ref="0" bb="32" group="104" />
+                </Parameter>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="Y9QRXUz8vE2eNCqN4e5H1A" name="UpperIleum_pls_UpperIleum_int" description="Neighborhood between Small Intestine/Mucosa/Upper Ileum/Plasma and Small Intestine/Mucosa/Upper Ileum/Interstitial" mode="Logical" containerType="Neighborhood" firstNeighbor="ExfgzEZMLEKihI9r6OGmqA" secondNeighbor="8d23X9v4OUO6u2MqRJcTOA">
+              <Tags>
+                <Tag value="Neighborhood: Plasma / Interstitial" />
+                <Tag value="Small intestine  neighborhood" />
+              </Tags>
+              <Children>
+                <Container id="Rhtz7jk_GUCSQqAk63NMOA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="pl1UGOfozEWk_yqrbuk_TA" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
+                      <ValueOrigin id="49" source="Other" method="Assumption" description="Assumption: very fast exchange" />
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="134" />
+                    </Parameter>
+                    <Parameter id="3R8P4iv4OE6aZeO8UwDXmA" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="iKUspopJzEClLaOxGRLgvw" isDefault="1">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="148" />
+                    </Parameter>
+                  </Children>
+                </Container>
+                <Parameter id="FIDIdvx1AEubBChr6Hb6XA" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="YX57qmODbU-M9-4csS_AyA" isDefault="1" displayUnit="cm²">
+                  <Tags>
+                    <Tag value="Neighborhood: Plasma / Interstitial" />
+                    <Tag value="Small intestine  neighborhood" />
+                  </Tags>
+                  <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                  <Info min="0" flag="122" seq="21" ref="0" bb="32" group="106" />
+                </Parameter>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="xOVw4vGGmEyVFxahnPnbGw" name="LowerIleum_int_LowerIleum_cell" description="Neighborhood between Small Intestine/Mucosa/Lower Ileum/Interstitial and Small Intestine/Mucosa/Lower Ileum/Intracellular" mode="Logical" containerType="Neighborhood" firstNeighbor="7b85cR4vJ0aGJEWuwq4eQA" secondNeighbor="0vcKW7cWtU23dRVwq49IaA">
+              <Tags>
+                <Tag value="Neighborhood: Interstitial / Intracellular" />
+                <Tag value="Small intestine  neighborhood" />
+              </Tags>
+              <Children>
+                <Container id="bO3qmz-OckSWEPS6367NAg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="TlitIqP4D02fq3rcfu22nw" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="BZvTAvj0WkmqeZtWTfgNdg" isDefault="1" displayUnit="cm/min">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="135" />
+                    </Parameter>
+                    <Parameter id="1s1Ko0AB60SZ5nbLuBFlYw" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="kVr36g4fqk6rVcAmgk03Gg" isDefault="1" displayUnit="cm/min">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="133" />
+                    </Parameter>
+                    <Parameter id="Wr6Tq35QNkmosuNrS_xFfw" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="SZrmcd1JDEW6MIjlHsCCew" isDefault="1" displayUnit="l/min">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="Mh3h1SGcoUyttqF43hnu3w" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="y659fcMlZEKHrLpFwmHmIw" isDefault="1" displayUnit="l/min">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="5ioqEy_5-EKP3t1gfL4zIQ" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="UgZ8q0MWoUqtJhxPStVohw" isDefault="1">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="4xpfuLxXMUmkjV-W4BwLUw" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="UgZ8q0MWoUqtJhxPStVohw" isDefault="1">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="07QXMxZbbUWpZ9E__J9jnA" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="LFxvD31Yj0GGjFItDGX_mg" isDefault="1">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="147" />
+                    </Parameter>
+                    <Parameter id="AiCkrWWS00q2IWqPpYfc_A" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="AGiWTt8CvEmeuesoKmPNgw" isDefault="1">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+                    </Parameter>
+                  </Children>
+                </Container>
+                <Parameter id="WmSoznEdt0yaEiN-sgXmBw" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="eCVRSCjBV0a7XUo2zmeH2A" isDefault="1" displayUnit="cm²">
+                  <Tags>
+                    <Tag value="Neighborhood: Interstitial / Intracellular" />
+                    <Tag value="Small intestine  neighborhood" />
+                  </Tags>
+                  <Info min="0" flag="122" seq="22" ref="0" bb="32" group="105" />
+                </Parameter>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="qoEVdL8cL0qBzuHMVmOFcQ" name="LowerIleum_pls_LowerIleum_bc" description="Neighborhood between Small Intestine/Mucosa/Lower Ileum/Plasma and Small Intestine/Mucosa/Lower Ileum/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="VAgy9eJ0pEWBUkCbQwloUw" secondNeighbor="UfLnRhyqGECHvI26DqDXOQ">
+              <Tags>
+                <Tag value="Neighborhood: Plasma / BloodCells" />
+                <Tag value="Small intestine  neighborhood" />
+              </Tags>
+              <Children>
+                <Container id="7AJwiPa-yUmTJOq0yxS5CA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+                <Parameter id="HZhygxfdY0ePwvc12TXpOQ" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="xH6OXEC65ESnPJ2unASWQA" isDefault="1" displayUnit="cm²">
+                  <Tags>
+                    <Tag value="Neighborhood: Plasma / BloodCells" />
+                    <Tag value="Small intestine  neighborhood" />
+                  </Tags>
+                  <Info min="0" flag="122" seq="25" ref="0" bb="32" group="104" />
+                </Parameter>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="kfyn_rUGj0CcHWhs6aLq7A" name="LowerIleum_pls_LowerIleum_int" description="Neighborhood between Small Intestine/Mucosa/Lower Ileum/Plasma and Small Intestine/Mucosa/Lower Ileum/Interstitial" mode="Logical" containerType="Neighborhood" firstNeighbor="VAgy9eJ0pEWBUkCbQwloUw" secondNeighbor="7b85cR4vJ0aGJEWuwq4eQA">
+              <Tags>
+                <Tag value="Neighborhood: Plasma / Interstitial" />
+                <Tag value="Small intestine  neighborhood" />
+              </Tags>
+              <Children>
+                <Container id="i6l4QGjgQEqdcr9cG6l_uQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="F44DDhO71E6do8te16aRWg" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
+                      <ValueOrigin id="49" source="Other" method="Assumption" description="Assumption: very fast exchange" />
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="134" />
+                    </Parameter>
+                    <Parameter id="ah8Euvl2Zkqu9nq3BIyPbQ" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="iKUspopJzEClLaOxGRLgvw" isDefault="1">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="148" />
+                    </Parameter>
+                  </Children>
+                </Container>
+                <Parameter id="hWVe_UaiwkO1D0C34x4EDw" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="YX57qmODbU-M9-4csS_AyA" isDefault="1" displayUnit="cm²">
+                  <Tags>
+                    <Tag value="Neighborhood: Plasma / Interstitial" />
+                    <Tag value="Small intestine  neighborhood" />
+                  </Tags>
+                  <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                  <Info min="0" flag="122" seq="22" ref="0" bb="32" group="106" />
+                </Parameter>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="7vLOKlm8TkODFGAlXYNrSw" name="Caecum_int_Caecum_cell" description="Neighborhood between Large Intestine/Mucosa/Cecum/Interstitial and Large Intestine/Mucosa/Cecum/Intracellular" mode="Logical" containerType="Neighborhood" firstNeighbor="CtrU9WUZf0qEHKEvvammJA" secondNeighbor="_AgQRAoUBU-0UiC2NRNm0w">
+              <Tags>
+                <Tag value="Large intestine  neighborhood" />
+                <Tag value="Neighborhood: Interstitial / Intracellular" />
+              </Tags>
+              <Children>
+                <Container id="DieeDZTi2EO2g3U0xkUn_Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="hvqrg8xjXUeD_9BhkFylfg" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="BZvTAvj0WkmqeZtWTfgNdg" isDefault="1" displayUnit="cm/min">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="135" />
+                    </Parameter>
+                    <Parameter id="jqpS28qxWkmWe88iV1af1Q" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="kVr36g4fqk6rVcAmgk03Gg" isDefault="1" displayUnit="cm/min">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="133" />
+                    </Parameter>
+                    <Parameter id="9csnllrjPEe70UBUtADp1Q" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="SZrmcd1JDEW6MIjlHsCCew" isDefault="1" displayUnit="l/min">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="A7b3Qc8s2k29b9tCgO96Rw" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="y659fcMlZEKHrLpFwmHmIw" isDefault="1" displayUnit="l/min">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="lgwvTeFszEi9-HEa8WiOkw" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="UgZ8q0MWoUqtJhxPStVohw" isDefault="1">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="y7-wbOzO3kKGSBVF6fSF-g" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="UgZ8q0MWoUqtJhxPStVohw" isDefault="1">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="43yDjuQjtU2QUXTOqvyV3Q" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="LFxvD31Yj0GGjFItDGX_mg" isDefault="1">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="147" />
+                    </Parameter>
+                    <Parameter id="da-YDUtiaUm0G2DRdS6VvA" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="AGiWTt8CvEmeuesoKmPNgw" isDefault="1">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+                    </Parameter>
+                  </Children>
+                </Container>
+                <Parameter id="ny7fDpLN5ESev_Sw9xeVTw" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="QaiQ4e5Fjk-PGrSi2ixG6w" isDefault="1" displayUnit="cm²">
+                  <Tags>
+                    <Tag value="Large intestine  neighborhood" />
+                    <Tag value="Neighborhood: Interstitial / Intracellular" />
+                  </Tags>
+                  <Info min="0" flag="122" seq="23" ref="0" bb="32" group="105" />
+                </Parameter>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="Dg-ayw3kW06wTrhUTglLPw" name="Caecum_pls_Caecum_bc" description="Neighborhood between Large Intestine/Mucosa/Cecum/Plasma and Large Intestine/Mucosa/Cecum/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="qukz-ldkCE-evbUN-Ei9Xg" secondNeighbor="6EXMi4P7Zk--PviGX-m75Q">
+              <Tags>
+                <Tag value="Large intestine  neighborhood" />
+                <Tag value="Neighborhood: Plasma / BloodCells" />
+              </Tags>
+              <Children>
+                <Container id="-5yHtBdnLUyJOI8NMWJsYQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+                <Parameter id="6bE63yR1YEeUsz3mqJ_tcA" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="xH6OXEC65ESnPJ2unASWQA" isDefault="1" displayUnit="cm²">
+                  <Tags>
+                    <Tag value="Large intestine  neighborhood" />
+                    <Tag value="Neighborhood: Plasma / BloodCells" />
+                  </Tags>
+                  <Info min="0" flag="122" seq="26" ref="0" bb="32" group="104" />
+                </Parameter>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="hj8UTCIgyECj3cdVBVspxw" name="Caecum_pls_Caecum_int" description="Neighborhood between Large Intestine/Mucosa/Cecum/Plasma and Large Intestine/Mucosa/Cecum/Interstitial" mode="Logical" containerType="Neighborhood" firstNeighbor="qukz-ldkCE-evbUN-Ei9Xg" secondNeighbor="CtrU9WUZf0qEHKEvvammJA">
+              <Tags>
+                <Tag value="Large intestine  neighborhood" />
+                <Tag value="Neighborhood: Plasma / Interstitial" />
+              </Tags>
+              <Children>
+                <Container id="LepXUe0Hc0yXd0yVW84fdw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="Pi5UjBZnnkOf2IgVeQBKIg" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
+                      <ValueOrigin id="49" source="Other" method="Assumption" description="Assumption: very fast exchange" />
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="134" />
+                    </Parameter>
+                    <Parameter id="AE2sIZNhOEKDEp8PbMpEXA" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="iKUspopJzEClLaOxGRLgvw" isDefault="1">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="148" />
+                    </Parameter>
+                  </Children>
+                </Container>
+                <Parameter id="yF3QFQvMx0S0n46GCRfKAg" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="YX57qmODbU-M9-4csS_AyA" isDefault="1" displayUnit="cm²">
+                  <Tags>
+                    <Tag value="Large intestine  neighborhood" />
+                    <Tag value="Neighborhood: Plasma / Interstitial" />
+                  </Tags>
+                  <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                  <Info min="0" flag="122" seq="23" ref="0" bb="32" group="106" />
+                </Parameter>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="No6u1xejsEyXZIhGz-n-5g" name="ColonAscendens_int_ColonAscendens_cell" description="Neighborhood between Large Intestine/Mucosa/Colon Ascendens/Interstitial and Large Intestine/Mucosa/Colon Ascendens/Intracellular" mode="Logical" containerType="Neighborhood" firstNeighbor="g9hqGHJYvkeWOhIzeQpElw" secondNeighbor="mI0h7BjrzU2jay0BKO-pig">
+              <Tags>
+                <Tag value="Large intestine  neighborhood" />
+                <Tag value="Neighborhood: Interstitial / Intracellular" />
+              </Tags>
+              <Children>
+                <Container id="l2OetWB8XUCjmgfbrtCO0w" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="pM1zDSVIWkyIWx69bClPBg" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="BZvTAvj0WkmqeZtWTfgNdg" isDefault="1" displayUnit="cm/min">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="135" />
+                    </Parameter>
+                    <Parameter id="r41Rt8uxuUugvINiI6iiYw" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="kVr36g4fqk6rVcAmgk03Gg" isDefault="1" displayUnit="cm/min">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="133" />
+                    </Parameter>
+                    <Parameter id="FL6C2TbyW0OOiFOIBnh-sQ" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="SZrmcd1JDEW6MIjlHsCCew" isDefault="1" displayUnit="l/min">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="_0W2HWYe7E-9znVfsX8mhA" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="y659fcMlZEKHrLpFwmHmIw" isDefault="1" displayUnit="l/min">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="YUKWkmX7TE6vGchyye8Ztw" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="UgZ8q0MWoUqtJhxPStVohw" isDefault="1">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="afsS2b-AhUOFJ-zG_sjmew" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="UgZ8q0MWoUqtJhxPStVohw" isDefault="1">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="JFfxS1V51ESupcjMH2LQsg" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="LFxvD31Yj0GGjFItDGX_mg" isDefault="1">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="147" />
+                    </Parameter>
+                    <Parameter id="gB5ySMUPAk2TBucm9dUxXg" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="AGiWTt8CvEmeuesoKmPNgw" isDefault="1">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+                    </Parameter>
+                  </Children>
+                </Container>
+                <Parameter id="Gv91_zeWW0qyVUy6cYQoFw" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="6QcbO30LpUqTT-QqTn9dYA" isDefault="1" displayUnit="cm²">
+                  <Tags>
+                    <Tag value="Large intestine  neighborhood" />
+                    <Tag value="Neighborhood: Interstitial / Intracellular" />
+                  </Tags>
+                  <Info min="0" flag="122" seq="24" ref="0" bb="32" group="105" />
+                </Parameter>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="p6f_fJqSEkGSQtFyDC4tGA" name="ColonAscendens_pls_ColonAscendens_bc" description="Neighborhood between Large Intestine/Mucosa/Colon Ascendens/Plasma and Large Intestine/Mucosa/Colon Ascendens/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="nddA3OCFX0GdKSVDib1zbQ" secondNeighbor="lFy3o88xskuHqY8VQAn88Q">
+              <Tags>
+                <Tag value="Large intestine  neighborhood" />
+                <Tag value="Neighborhood: Plasma / BloodCells" />
+              </Tags>
+              <Children>
+                <Container id="aPQJ1oiiDkO75OXDPb43ZQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+                <Parameter id="tDGbsQd0uUWw9L9F9mxYDQ" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="xH6OXEC65ESnPJ2unASWQA" isDefault="1" displayUnit="cm²">
+                  <Tags>
+                    <Tag value="Large intestine  neighborhood" />
+                    <Tag value="Neighborhood: Plasma / BloodCells" />
+                  </Tags>
+                  <Info min="0" flag="122" seq="27" ref="0" bb="32" group="104" />
+                </Parameter>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="vMiLu5aLhkyN9ISDAQvvrA" name="ColonAscendens_pls_ColonAscendens_int" description="Neighborhood between Large Intestine/Mucosa/Colon Ascendens/Plasma and Large Intestine/Mucosa/Colon Ascendens/Interstitial" mode="Logical" containerType="Neighborhood" firstNeighbor="nddA3OCFX0GdKSVDib1zbQ" secondNeighbor="g9hqGHJYvkeWOhIzeQpElw">
+              <Tags>
+                <Tag value="Large intestine  neighborhood" />
+                <Tag value="Neighborhood: Plasma / Interstitial" />
+              </Tags>
+              <Children>
+                <Container id="vV26N_qIz0GJb-LqvLfXgA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="-Cmlt_C5CUGd8jMsszHF3A" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
+                      <ValueOrigin id="49" source="Other" method="Assumption" description="Assumption: very fast exchange" />
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="134" />
+                    </Parameter>
+                    <Parameter id="6JBXRd6rCEuKw7uGn6k8bQ" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="iKUspopJzEClLaOxGRLgvw" isDefault="1">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="148" />
+                    </Parameter>
+                  </Children>
+                </Container>
+                <Parameter id="l-Za2GP2qEuaaek8JSDeNQ" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="YX57qmODbU-M9-4csS_AyA" isDefault="1" displayUnit="cm²">
+                  <Tags>
+                    <Tag value="Large intestine  neighborhood" />
+                    <Tag value="Neighborhood: Plasma / Interstitial" />
+                  </Tags>
+                  <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                  <Info min="0" flag="122" seq="24" ref="0" bb="32" group="106" />
+                </Parameter>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="7Ys8jwPIe0Ga8NV8GSvZ3A" name="ColonTransversum_int_ColonTransversum_cell" description="Neighborhood between Large Intestine/Mucosa/Colon Transversum/Interstitial and Large Intestine/Mucosa/Colon Transversum/Intracellular" mode="Logical" containerType="Neighborhood" firstNeighbor="7G_St76qx0mqUjrG7nB_fA" secondNeighbor="rFBqnzSBzUej0jy-NJYHwQ">
+              <Tags>
+                <Tag value="Large intestine  neighborhood" />
+                <Tag value="Neighborhood: Interstitial / Intracellular" />
+              </Tags>
+              <Children>
+                <Container id="EZz04kRQy0-KdlyZJpQ3ng" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="zULAzcpNz0SMdXpL4Yk3xQ" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="BZvTAvj0WkmqeZtWTfgNdg" isDefault="1" displayUnit="cm/min">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="135" />
+                    </Parameter>
+                    <Parameter id="0t2wjYUWM0OBJHuqaQvsQQ" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="kVr36g4fqk6rVcAmgk03Gg" isDefault="1" displayUnit="cm/min">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="133" />
+                    </Parameter>
+                    <Parameter id="B2hmTw7mckmXOU2g8fKlcg" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="SZrmcd1JDEW6MIjlHsCCew" isDefault="1" displayUnit="l/min">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="H9x98LODeUeVHMXMSa8Q4g" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="y659fcMlZEKHrLpFwmHmIw" isDefault="1" displayUnit="l/min">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="7kzcINCym0K6VJdhRaM0vQ" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="UgZ8q0MWoUqtJhxPStVohw" isDefault="1">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="3VeUEESAjUmByWvmNRqD0w" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="UgZ8q0MWoUqtJhxPStVohw" isDefault="1">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="oj2IEVrVR06vF0EErQZN3w" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="LFxvD31Yj0GGjFItDGX_mg" isDefault="1">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="147" />
+                    </Parameter>
+                    <Parameter id="nwxKdi9yvU6tgqSrzhYTKw" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="AGiWTt8CvEmeuesoKmPNgw" isDefault="1">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+                    </Parameter>
+                  </Children>
+                </Container>
+                <Parameter id="u0x4NoLvbk2A6SXFy9wmiA" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="2IZUbYMmYEKZlHpTU5xwlg" isDefault="1" displayUnit="cm²">
+                  <Tags>
+                    <Tag value="Large intestine  neighborhood" />
+                    <Tag value="Neighborhood: Interstitial / Intracellular" />
+                  </Tags>
+                  <Info min="0" flag="122" seq="25" ref="0" bb="32" group="105" />
+                </Parameter>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="lTGnBDRrm0W2D2x9Ax-Wfw" name="ColonTransversum_pls_ColonTransversum_bc" description="Neighborhood between Large Intestine/Mucosa/Colon Transversum/Plasma and Large Intestine/Mucosa/Colon Transversum/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="cSWtcUReDEOC_vr4QwkFJA" secondNeighbor="9tf7XE_EBkqMwcotfbazmQ">
+              <Tags>
+                <Tag value="Large intestine  neighborhood" />
+                <Tag value="Neighborhood: Plasma / BloodCells" />
+              </Tags>
+              <Children>
+                <Container id="ji-14iqlFkmMhk3Uk4ZFcA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+                <Parameter id="GzcvIUsB5Ua6GTGJ1TJnZA" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="xH6OXEC65ESnPJ2unASWQA" isDefault="1" displayUnit="cm²">
+                  <Tags>
+                    <Tag value="Large intestine  neighborhood" />
+                    <Tag value="Neighborhood: Plasma / BloodCells" />
+                  </Tags>
+                  <Info min="0" flag="122" seq="28" ref="0" bb="32" group="104" />
+                </Parameter>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="RC-XVUe4P0OgPpG2JnBi2Q" name="ColonTransversum_pls_ColonTransversum_int" description="Neighborhood between Large Intestine/Mucosa/Colon Transversum/Plasma and Large Intestine/Mucosa/Colon Transversum/Interstitial" mode="Logical" containerType="Neighborhood" firstNeighbor="cSWtcUReDEOC_vr4QwkFJA" secondNeighbor="7G_St76qx0mqUjrG7nB_fA">
+              <Tags>
+                <Tag value="Large intestine  neighborhood" />
+                <Tag value="Neighborhood: Plasma / Interstitial" />
+              </Tags>
+              <Children>
+                <Container id="3LU5RGCuZ0C7gTLCHQAsUQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="Ai1SC4cM8UKGRN2nThk-KQ" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
+                      <ValueOrigin id="49" source="Other" method="Assumption" description="Assumption: very fast exchange" />
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="134" />
+                    </Parameter>
+                    <Parameter id="tV7WABobokqyD9lw5i6nIg" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="iKUspopJzEClLaOxGRLgvw" isDefault="1">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="148" />
+                    </Parameter>
+                  </Children>
+                </Container>
+                <Parameter id="5j8XBO-s3ESpj3KfdA9ajg" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="YX57qmODbU-M9-4csS_AyA" isDefault="1" displayUnit="cm²">
+                  <Tags>
+                    <Tag value="Large intestine  neighborhood" />
+                    <Tag value="Neighborhood: Plasma / Interstitial" />
+                  </Tags>
+                  <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                  <Info min="0" flag="122" seq="25" ref="0" bb="32" group="106" />
+                </Parameter>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="tA26zxnvjkqMM3JimNP9_A" name="ColonDescendens_int_ColonDescendens_cell" description="Neighborhood between Large Intestine/Mucosa/Colon Descendens/Interstitial and Large Intestine/Mucosa/Colon Descendens/Intracellular" mode="Logical" containerType="Neighborhood" firstNeighbor="WJhsAHbQDkuE3t4ndWlF_w" secondNeighbor="zsiyKimiGEeUQIIZc604yg">
+              <Tags>
+                <Tag value="Large intestine  neighborhood" />
+                <Tag value="Neighborhood: Interstitial / Intracellular" />
+              </Tags>
+              <Children>
+                <Container id="9TF-X3dxgkGY1XJhj4f9pg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="D3b2Y2tm60Ss12J6EIZk0A" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="BZvTAvj0WkmqeZtWTfgNdg" isDefault="1" displayUnit="cm/min">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="135" />
+                    </Parameter>
+                    <Parameter id="q1T1Vapx4kyyOKiAQtX5nw" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="kVr36g4fqk6rVcAmgk03Gg" isDefault="1" displayUnit="cm/min">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="133" />
+                    </Parameter>
+                    <Parameter id="_4WO64iJaEKTjmdWjC1YOQ" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="SZrmcd1JDEW6MIjlHsCCew" isDefault="1" displayUnit="l/min">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="cN3w_R4_l06Dtn0CoZMGbg" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="y659fcMlZEKHrLpFwmHmIw" isDefault="1" displayUnit="l/min">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="1qCHhQor90WDngV2WMGD3g" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="UgZ8q0MWoUqtJhxPStVohw" isDefault="1">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="ntbdF1H1mkWgkuwDp5eMcQ" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="UgZ8q0MWoUqtJhxPStVohw" isDefault="1">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="xJugzcnZu0uNN2wIO83tKA" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="LFxvD31Yj0GGjFItDGX_mg" isDefault="1">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="147" />
+                    </Parameter>
+                    <Parameter id="pyO7feYHw0utJkfo9MSAfg" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="AGiWTt8CvEmeuesoKmPNgw" isDefault="1">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+                    </Parameter>
+                  </Children>
+                </Container>
+                <Parameter id="jVNbuPDTTk-ULAnLu7wOaA" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="QMbfeMR5_UW7IlN5ZhsElw" isDefault="1" displayUnit="cm²">
+                  <Tags>
+                    <Tag value="Large intestine  neighborhood" />
+                    <Tag value="Neighborhood: Interstitial / Intracellular" />
+                  </Tags>
+                  <Info min="0" flag="122" seq="26" ref="0" bb="32" group="105" />
+                </Parameter>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="IaDNpAFs3UaY7pAw_Z2rBw" name="ColonDescendens_pls_ColonDescendens_bc" description="Neighborhood between Large Intestine/Mucosa/Colon Descendens/Plasma and Large Intestine/Mucosa/Colon Descendens/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="pIzMA-eWSUisOrBZ-cC5jw" secondNeighbor="b1XobftQwUiN9-8v8K-ffA">
+              <Tags>
+                <Tag value="Large intestine  neighborhood" />
+                <Tag value="Neighborhood: Plasma / BloodCells" />
+              </Tags>
+              <Children>
+                <Container id="l5F8lKM6wEG-23Ql164_Rg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+                <Parameter id="WOedyFIWZUOi6Xv2U5eINw" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="xH6OXEC65ESnPJ2unASWQA" isDefault="1" displayUnit="cm²">
+                  <Tags>
+                    <Tag value="Large intestine  neighborhood" />
+                    <Tag value="Neighborhood: Plasma / BloodCells" />
+                  </Tags>
+                  <Info min="0" flag="122" seq="29" ref="0" bb="32" group="104" />
+                </Parameter>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="LG58vB1YtkO9I9TAMY0WDQ" name="ColonDescendens_pls_ColonDescendens_int" description="Neighborhood between Large Intestine/Mucosa/Colon Descendens/Plasma and Large Intestine/Mucosa/Colon Descendens/Interstitial" mode="Logical" containerType="Neighborhood" firstNeighbor="pIzMA-eWSUisOrBZ-cC5jw" secondNeighbor="WJhsAHbQDkuE3t4ndWlF_w">
+              <Tags>
+                <Tag value="Large intestine  neighborhood" />
+                <Tag value="Neighborhood: Plasma / Interstitial" />
+              </Tags>
+              <Children>
+                <Container id="o9_ol3dQU0q0AY7EKidfdQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="Wv2vW_ft-kyVwExrB7HA-g" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
+                      <ValueOrigin id="49" source="Other" method="Assumption" description="Assumption: very fast exchange" />
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="134" />
+                    </Parameter>
+                    <Parameter id="YQVrF83vq0ic_T7GY32w7w" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="iKUspopJzEClLaOxGRLgvw" isDefault="1">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="148" />
+                    </Parameter>
+                  </Children>
+                </Container>
+                <Parameter id="vZcoDEAem0Wh672ZAsYxtQ" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="YX57qmODbU-M9-4csS_AyA" isDefault="1" displayUnit="cm²">
+                  <Tags>
+                    <Tag value="Large intestine  neighborhood" />
+                    <Tag value="Neighborhood: Plasma / Interstitial" />
+                  </Tags>
+                  <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                  <Info min="0" flag="122" seq="26" ref="0" bb="32" group="106" />
+                </Parameter>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="YhHiFnxrSUu4mwIrirbzbQ" name="ColonSigmoid_int_ColonSigmoid_cell" description="Neighborhood between Large Intestine/Mucosa/Colon Sigmoid/Interstitial and Large Intestine/Mucosa/Colon Sigmoid/Intracellular" mode="Logical" containerType="Neighborhood" firstNeighbor="-BJYLLzaN0GrVt8nmTiwTQ" secondNeighbor="mN0sgeauwEOO8CBAEY9_3g">
+              <Tags>
+                <Tag value="Large intestine  neighborhood" />
+                <Tag value="Neighborhood: Interstitial / Intracellular" />
+              </Tags>
+              <Children>
+                <Container id="MOUiNWEx_kGwLPikfxQ05g" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="7za855G9lEa_pQFraKakbQ" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="BZvTAvj0WkmqeZtWTfgNdg" isDefault="1" displayUnit="cm/min">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="135" />
+                    </Parameter>
+                    <Parameter id="AsKuXXvwoEqJ8OeakOLhQA" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="kVr36g4fqk6rVcAmgk03Gg" isDefault="1" displayUnit="cm/min">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="133" />
+                    </Parameter>
+                    <Parameter id="y7RRchRAkkKxlyVJlThlng" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="SZrmcd1JDEW6MIjlHsCCew" isDefault="1" displayUnit="l/min">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="A1vjKcqCEEe8DQMlXBus9A" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="y659fcMlZEKHrLpFwmHmIw" isDefault="1" displayUnit="l/min">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="fug--zTHbUKOFtolDlfUzA" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="UgZ8q0MWoUqtJhxPStVohw" isDefault="1">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="qJv0ReNP2kGe3hi47mR0Kg" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="UgZ8q0MWoUqtJhxPStVohw" isDefault="1">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="yvk7i15a1kyus3I2CGZB6g" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="LFxvD31Yj0GGjFItDGX_mg" isDefault="1">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="147" />
+                    </Parameter>
+                    <Parameter id="lf4BUjAlsE-S5bAU3qylrA" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="AGiWTt8CvEmeuesoKmPNgw" isDefault="1">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+                    </Parameter>
+                  </Children>
+                </Container>
+                <Parameter id="kklpw6YeukWArFswjdpnGQ" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="1SPuRgyi4ECx-nmkxsC6Zg" isDefault="1" displayUnit="cm²">
+                  <Tags>
+                    <Tag value="Large intestine  neighborhood" />
+                    <Tag value="Neighborhood: Interstitial / Intracellular" />
+                  </Tags>
+                  <Info min="0" flag="122" seq="27" ref="0" bb="32" group="105" />
+                </Parameter>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="FyostfFta0yb9O7TkWrSJQ" name="ColonSigmoid_pls_ColonSigmoid_bc" description="Neighborhood between Large Intestine/Mucosa/Colon Sigmoid/Plasma and Large Intestine/Mucosa/Colon Sigmoid/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="NnYDxAvR50id6cKL1JK05A" secondNeighbor="9rh5uMJZKkCrCkUcs7GNfA">
+              <Tags>
+                <Tag value="Large intestine  neighborhood" />
+                <Tag value="Neighborhood: Plasma / BloodCells" />
+              </Tags>
+              <Children>
+                <Container id="vBxvZmoXBUeNHm04f5mRHw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+                <Parameter id="CxR7zfSgXEWo4amoV1HbtA" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="xH6OXEC65ESnPJ2unASWQA" isDefault="1" displayUnit="cm²">
+                  <Tags>
+                    <Tag value="Large intestine  neighborhood" />
+                    <Tag value="Neighborhood: Plasma / BloodCells" />
+                  </Tags>
+                  <Info min="0" flag="122" seq="30" ref="0" bb="32" group="104" />
+                </Parameter>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="l_NojvJtSk2SZgBVazhkUw" name="ColonSigmoid_pls_ColonSigmoid_int" description="Neighborhood between Large Intestine/Mucosa/Colon Sigmoid/Plasma and Large Intestine/Mucosa/Colon Sigmoid/Interstitial" mode="Logical" containerType="Neighborhood" firstNeighbor="NnYDxAvR50id6cKL1JK05A" secondNeighbor="-BJYLLzaN0GrVt8nmTiwTQ">
+              <Tags>
+                <Tag value="Large intestine  neighborhood" />
+                <Tag value="Neighborhood: Plasma / Interstitial" />
+              </Tags>
+              <Children>
+                <Container id="Q711VAdOeEmw6v9ZjZG5eQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="8REHdq7psEKhkW0QZeDfyw" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
+                      <ValueOrigin id="49" source="Other" method="Assumption" description="Assumption: very fast exchange" />
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="134" />
+                    </Parameter>
+                    <Parameter id="xgcPDoBA7ESHoe_dEjRxCA" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="iKUspopJzEClLaOxGRLgvw" isDefault="1">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="148" />
+                    </Parameter>
+                  </Children>
+                </Container>
+                <Parameter id="K1dowp4hnkamUyf4aEWXXA" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="YX57qmODbU-M9-4csS_AyA" isDefault="1" displayUnit="cm²">
+                  <Tags>
+                    <Tag value="Large intestine  neighborhood" />
+                    <Tag value="Neighborhood: Plasma / Interstitial" />
+                  </Tags>
+                  <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                  <Info min="0" flag="122" seq="27" ref="0" bb="32" group="106" />
+                </Parameter>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="SAs55JwhiUqmZTeAJwf2zw" name="Rectum_int_Rectum_cell" description="Neighborhood between Large Intestine/Mucosa/Rectum/Interstitial and Large Intestine/Mucosa/Rectum/Intracellular" mode="Logical" containerType="Neighborhood" firstNeighbor="c6iso5cc4Eu-rSgVPq2QxA" secondNeighbor="Rn97Mtjr40q020tADawIvg">
+              <Tags>
+                <Tag value="Large intestine  neighborhood" />
+                <Tag value="Neighborhood: Interstitial / Intracellular" />
+              </Tags>
+              <Children>
+                <Container id="or3-DY58zUGCEoMX73rl6Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="pfj--1DawkCBgoHymZ14EQ" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="BZvTAvj0WkmqeZtWTfgNdg" isDefault="1" displayUnit="cm/min">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="135" />
+                    </Parameter>
+                    <Parameter id="6TtZSCun_UuIDGxYtn041g" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="kVr36g4fqk6rVcAmgk03Gg" isDefault="1" displayUnit="cm/min">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="133" />
+                    </Parameter>
+                    <Parameter id="Mjg4xWSP30ygZitd7D_gWQ" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="SZrmcd1JDEW6MIjlHsCCew" isDefault="1" displayUnit="l/min">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="a31JdJcYYEKTjNJkNj_Eag" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="y659fcMlZEKHrLpFwmHmIw" isDefault="1" displayUnit="l/min">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="lma7ecMZ9UuCdxO_Fm1nsg" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="UgZ8q0MWoUqtJhxPStVohw" isDefault="1">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="ZJvoggA3y0C_wbkuGBAnEA" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="UgZ8q0MWoUqtJhxPStVohw" isDefault="1">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="cnk2Z78Ae02nHZ7cnfiJKw" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="LFxvD31Yj0GGjFItDGX_mg" isDefault="1">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="147" />
+                    </Parameter>
+                    <Parameter id="CZOxBzot7U2oOECQpgpUhQ" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="AGiWTt8CvEmeuesoKmPNgw" isDefault="1">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+                    </Parameter>
+                  </Children>
+                </Container>
+                <Parameter id="ArwobIE1TU6yzQ1UcRkFWw" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Y3niiL_5sEet3wsdSNLfPw" isDefault="1" displayUnit="cm²">
+                  <Tags>
+                    <Tag value="Large intestine  neighborhood" />
+                    <Tag value="Neighborhood: Interstitial / Intracellular" />
+                  </Tags>
+                  <Info min="0" flag="122" seq="28" ref="0" bb="32" group="105" />
+                </Parameter>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="2TyLzo4tkE-LvNpbVNPQiA" name="Rectum_pls_Rectum_bc" description="Neighborhood between Large Intestine/Mucosa/Rectum/Plasma and Large Intestine/Mucosa/Rectum/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="gR3w3fNA-kyAJ2dbxne0lw" secondNeighbor="mfre2X8CW0iMNT9dYG5xdg">
+              <Tags>
+                <Tag value="Large intestine  neighborhood" />
+                <Tag value="Neighborhood: Plasma / BloodCells" />
+              </Tags>
+              <Children>
+                <Container id="6rmWz_LiuESpcZ9PSGYSOw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+                <Parameter id="yMshPY44QkOo2aHjPj_CSA" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="xH6OXEC65ESnPJ2unASWQA" isDefault="1" displayUnit="cm²">
+                  <Tags>
+                    <Tag value="Large intestine  neighborhood" />
+                    <Tag value="Neighborhood: Plasma / BloodCells" />
+                  </Tags>
+                  <Info min="0" flag="122" seq="31" ref="0" bb="32" group="104" />
+                </Parameter>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="bp2QuyqTlkOusWgLvLd0TA" name="Rectum_pls_Rectum_int" description="Neighborhood between Large Intestine/Mucosa/Rectum/Plasma and Large Intestine/Mucosa/Rectum/Interstitial" mode="Logical" containerType="Neighborhood" firstNeighbor="gR3w3fNA-kyAJ2dbxne0lw" secondNeighbor="c6iso5cc4Eu-rSgVPq2QxA">
+              <Tags>
+                <Tag value="Large intestine  neighborhood" />
+                <Tag value="Neighborhood: Plasma / Interstitial" />
+              </Tags>
+              <Children>
+                <Container id="c4LO9RWN-EK8vLzKN9VHSg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="zMvue-Ks6EaCzoKgFrLegQ" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
+                      <ValueOrigin id="49" source="Other" method="Assumption" description="Assumption: very fast exchange" />
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="134" />
+                    </Parameter>
+                    <Parameter id="rKn95bsq6Eip960sghfESg" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="iKUspopJzEClLaOxGRLgvw" isDefault="1">
+                      <Info min="0" flag="122" seq="1" ref="0" bb="2" group="148" />
+                    </Parameter>
+                  </Children>
+                </Container>
+                <Parameter id="CndcBimzpkKUcQ5cAfK7yw" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="YX57qmODbU-M9-4csS_AyA" isDefault="1" displayUnit="cm²">
+                  <Tags>
+                    <Tag value="Large intestine  neighborhood" />
+                    <Tag value="Neighborhood: Plasma / Interstitial" />
+                  </Tags>
+                  <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                  <Info min="0" flag="122" seq="28" ref="0" bb="32" group="106" />
+                </Parameter>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="KBewaBy_pUi3YLmNVFEfWA" name="ArterialBlood_bc_Bone_bc" description="Neighborhood between Arterial Blood/Blood Cells and Bone/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="bE0VJ8a31Uyaciw1C0jzTg" secondNeighbor="wRGMBojr30ywQhW67eF8qw">
+              <Tags>
+                <Tag value="Neighborhood: BloodCells / BloodCells" />
+              </Tags>
+              <Children>
+                <Container id="0lW_ktzbGE6dksoUMxEM0Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="Y371iMBhXUSYTZuX8p7ohA" name="ArterialBlood_bc_Brain_bc" description="Neighborhood between Arterial Blood/Blood Cells and Brain/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="bE0VJ8a31Uyaciw1C0jzTg" secondNeighbor="bN3VXHsGO0OXJk_ZKrzMRA">
+              <Tags>
+                <Tag value="Neighborhood: BloodCells / BloodCells" />
+              </Tags>
+              <Children>
+                <Container id="Bon6JPXNM0y9fDBYDjv86A" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="IldrorF_0Uyeg65jiW-AhA" name="ArterialBlood_bc_Fat_bc" description="Neighborhood between Arterial Blood/Blood Cells and Fat/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="bE0VJ8a31Uyaciw1C0jzTg" secondNeighbor="y-Nrpm_4AEGF3WJNdy4pUQ">
+              <Tags>
+                <Tag value="Neighborhood: BloodCells / BloodCells" />
+              </Tags>
+              <Children>
+                <Container id="LvxKAABrTkqL-rYADApPPg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="cUTDasY3dU2F1FAIiK_7Fg" name="ArterialBlood_bc_Gonads_bc" description="Neighborhood between Arterial Blood/Blood Cells and Gonads/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="bE0VJ8a31Uyaciw1C0jzTg" secondNeighbor="PDxTJKGF10G81bGQzM6xCA">
+              <Tags>
+                <Tag value="Neighborhood: BloodCells / BloodCells" />
+              </Tags>
+              <Children>
+                <Container id="pFIeqYY8x0iby-SzZ7MgIA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="6O20aGn9U0eLc_wh85Nb1A" name="ArterialBlood_bc_Heart_bc" description="Neighborhood between Arterial Blood/Blood Cells and Heart/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="bE0VJ8a31Uyaciw1C0jzTg" secondNeighbor="XGjCqmNgsEiMW9ot69l81A">
+              <Tags>
+                <Tag value="Neighborhood: BloodCells / BloodCells" />
+              </Tags>
+              <Children>
+                <Container id="MMCxr62qbEKq640nk2p4VQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="_SBLaCVghkynsftk2_EANg" name="ArterialBlood_bc_Kidney_bc" description="Neighborhood between Arterial Blood/Blood Cells and Kidney/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="bE0VJ8a31Uyaciw1C0jzTg" secondNeighbor="fpo7n9IKhEKtWLMWgD88GQ">
+              <Tags>
+                <Tag value="Neighborhood: BloodCells / BloodCells" />
+              </Tags>
+              <Children>
+                <Container id="GS36zUYLzkWClHpGXondRw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="7UJKpfSHpk-ETqmNyvuTZw" name="ArterialBlood_bc_LargeIntestine_bc" description="Neighborhood between Arterial Blood/Blood Cells and Large Intestine/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="bE0VJ8a31Uyaciw1C0jzTg" secondNeighbor="wsEjCxUbhEew0Q0BivassA">
+              <Tags>
+                <Tag value="Neighborhood: BloodCells / BloodCells" />
+              </Tags>
+              <Children>
+                <Container id="2zYA_UnfXk2IT9lfmS-NUQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="Bt1VZTnnlUeOkteAHu-y6A" name="ArterialBlood_bc_Muscle_bc" description="Neighborhood between Arterial Blood/Blood Cells and Muscle/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="bE0VJ8a31Uyaciw1C0jzTg" secondNeighbor="79ZV95ZikEqUvwM-RF-COg">
+              <Tags>
+                <Tag value="Neighborhood: BloodCells / BloodCells" />
+              </Tags>
+              <Children>
+                <Container id="ZD5JVRJboESJ7vnu0ehswg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="FwdKD5Kq_0SJ1ik28Fy9XQ" name="ArterialBlood_bc_Pancreas_bc" description="Neighborhood between Arterial Blood/Blood Cells and Pancreas/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="bE0VJ8a31Uyaciw1C0jzTg" secondNeighbor="rBmONNF-9U-E114Fh8WruQ">
+              <Tags>
+                <Tag value="Neighborhood: BloodCells / BloodCells" />
+              </Tags>
+              <Children>
+                <Container id="9l-8OEEmY0CihJ7iGIHXdg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="B6tWC_7WaE6mX8rBExn7ew" name="ArterialBlood_bc_Skin_bc" description="Neighborhood between Arterial Blood/Blood Cells and Skin/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="bE0VJ8a31Uyaciw1C0jzTg" secondNeighbor="oEd7E3QlUUWulGR8Pf0DSQ">
+              <Tags>
+                <Tag value="Neighborhood: BloodCells / BloodCells" />
+              </Tags>
+              <Children>
+                <Container id="X9jLNJGDWEOQurAU2TIA4w" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="_aq_URcjikykpia24m3iGw" name="ArterialBlood_bc_SmallIntestine_bc" description="Neighborhood between Arterial Blood/Blood Cells and Small Intestine/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="bE0VJ8a31Uyaciw1C0jzTg" secondNeighbor="E0vWo0BDME6DiS7jT6IlYg">
+              <Tags>
+                <Tag value="Neighborhood: BloodCells / BloodCells" />
+              </Tags>
+              <Children>
+                <Container id="gOgi5rS5QUyb4mbZ9bY8sg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="rzM3nLWBf0moPbd9t_wiGg" name="ArterialBlood_bc_Spleen_bc" description="Neighborhood between Arterial Blood/Blood Cells and Spleen/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="bE0VJ8a31Uyaciw1C0jzTg" secondNeighbor="M2WKAv8OrkawUNjTsjLgyg">
+              <Tags>
+                <Tag value="Neighborhood: BloodCells / BloodCells" />
+              </Tags>
+              <Children>
+                <Container id="RoJGSsRJn0OIIJh5YW6Hig" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="Ztj7u2HCvkSO3KE-0Sdk_A" name="ArterialBlood_bc_Stomach_bc" description="Neighborhood between Arterial Blood/Blood Cells and Stomach/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="bE0VJ8a31Uyaciw1C0jzTg" secondNeighbor="zHyBX88dpUCaGtm-lIfGkA">
+              <Tags>
+                <Tag value="Neighborhood: BloodCells / BloodCells" />
+              </Tags>
+              <Children>
+                <Container id="6lq4NaJE-Eut244rOxggvA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="4iRvelijpkWUzZIEMdZAMg" name="ArterialBlood_pls_Bone_pls" description="Neighborhood between Arterial Blood/Plasma and Bone/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="Hl-Gd6HA30OOrhWd5UIAVQ" secondNeighbor="GOuaccg6akC1RvBP5q6UXA">
+              <Tags>
+                <Tag value="Neighborhood: Plasma / Plasma" />
+              </Tags>
+              <Children>
+                <Container id="ObUNT3TapUaLNDEhM0Jz9g" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="2f3OD4_Kv0GEOPAkWT223w" name="ArterialBlood_pls_Brain_pls" description="Neighborhood between Arterial Blood/Plasma and Brain/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="Hl-Gd6HA30OOrhWd5UIAVQ" secondNeighbor="7DNB5PpQXESK4u6Vgt7P3w">
+              <Tags>
+                <Tag value="Neighborhood: Plasma / Plasma" />
+              </Tags>
+              <Children>
+                <Container id="iJwE3EqIeE699hsQFTlNZQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="Aa3X5QOhq06hNSAd4jw3tw" name="ArterialBlood_pls_Fat_pls" description="Neighborhood between Arterial Blood/Plasma and Fat/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="Hl-Gd6HA30OOrhWd5UIAVQ" secondNeighbor="hrh6Bbq1yECrUjUyce8Xvg">
+              <Tags>
+                <Tag value="Neighborhood: Plasma / Plasma" />
+              </Tags>
+              <Children>
+                <Container id="OGF5njaTD0qpfrR8gThG4w" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="glUdq3KH302wZG9euQvACw" name="ArterialBlood_pls_Gonads_pls" description="Neighborhood between Arterial Blood/Plasma and Gonads/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="Hl-Gd6HA30OOrhWd5UIAVQ" secondNeighbor="yPB5n3md30-4KI9XTzIWaA">
+              <Tags>
+                <Tag value="Neighborhood: Plasma / Plasma" />
+              </Tags>
+              <Children>
+                <Container id="-a7j0ejEk0eI8rkNp8QwBg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="9IHnKJdTcki17EzZ73rLBg" name="ArterialBlood_pls_Heart_pls" description="Neighborhood between Arterial Blood/Plasma and Heart/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="Hl-Gd6HA30OOrhWd5UIAVQ" secondNeighbor="--ffw1zMZEOBxhdNSV1Q1w">
+              <Tags>
+                <Tag value="Neighborhood: Plasma / Plasma" />
+              </Tags>
+              <Children>
+                <Container id="bxVMgQAbqEiPuv2v3pUNMg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="Lmez5lVUUEuinUNAzrBNfA" name="ArterialBlood_pls_Kidney_pls" description="Neighborhood between Arterial Blood/Plasma and Kidney/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="Hl-Gd6HA30OOrhWd5UIAVQ" secondNeighbor="g0ppnZPQBkqwKVu3lsxWKw">
+              <Tags>
+                <Tag value="Neighborhood: Plasma / Plasma" />
+              </Tags>
+              <Children>
+                <Container id="QIaZlGvHg0G-ponRVe8cfA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="gxCRNpjtwUaFhxMIewMjHA" name="ArterialBlood_pls_LargeIntestine_pls" description="Neighborhood between Arterial Blood/Plasma and Large Intestine/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="Hl-Gd6HA30OOrhWd5UIAVQ" secondNeighbor="yOFV-yMQV0u3LENWNLEw4w">
+              <Tags>
+                <Tag value="Neighborhood: Plasma / Plasma" />
+              </Tags>
+              <Children>
+                <Container id="fXsKs6FYo0qiVra6me98Hw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="1W4QA_ZRuU2_igoXsGEyOg" name="ArterialBlood_pls_Muscle_pls" description="Neighborhood between Arterial Blood/Plasma and Muscle/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="Hl-Gd6HA30OOrhWd5UIAVQ" secondNeighbor="_MamKH2EmEu_zsln6IKUnQ">
+              <Tags>
+                <Tag value="Neighborhood: Plasma / Plasma" />
+              </Tags>
+              <Children>
+                <Container id="sXfox-Io-0OXEgIxJ5upBA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="sC84-MlF4U-KBHgsImmUhg" name="ArterialBlood_pls_Pancreas_pls" description="Neighborhood between Arterial Blood/Plasma and Pancreas/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="Hl-Gd6HA30OOrhWd5UIAVQ" secondNeighbor="m5U8oucV-EO-_1sOC7LuFQ">
+              <Tags>
+                <Tag value="Neighborhood: Plasma / Plasma" />
+              </Tags>
+              <Children>
+                <Container id="Jrm5Fw-6ikepE_97SIaY-g" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="0cYHCu8j5U2BFFyL8cG-hA" name="ArterialBlood_pls_Skin_pls" description="Neighborhood between Arterial Blood/Plasma and Skin/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="Hl-Gd6HA30OOrhWd5UIAVQ" secondNeighbor="eLnrUcbYMk6o07W_5SFa_A">
+              <Tags>
+                <Tag value="Neighborhood: Plasma / Plasma" />
+              </Tags>
+              <Children>
+                <Container id="nROAAO6ldUWWwJpSPLHoDw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="uts2VcdoXUmzboE212EqSg" name="ArterialBlood_pls_SmallIntestine_pls" description="Neighborhood between Arterial Blood/Plasma and Small Intestine/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="Hl-Gd6HA30OOrhWd5UIAVQ" secondNeighbor="7uENbPvU7kOunFwGm9NtzA">
+              <Tags>
+                <Tag value="Neighborhood: Plasma / Plasma" />
+              </Tags>
+              <Children>
+                <Container id="yBPd35nny0KSvtLmmwUsJw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="ybYx0xyH60y_cDO9KSF9dg" name="ArterialBlood_pls_Spleen_pls" description="Neighborhood between Arterial Blood/Plasma and Spleen/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="Hl-Gd6HA30OOrhWd5UIAVQ" secondNeighbor="b277qVHUMki37Y-xN7qKrQ">
+              <Tags>
+                <Tag value="Neighborhood: Plasma / Plasma" />
+              </Tags>
+              <Children>
+                <Container id="qEgVC5zeaU2TE1NKYZ4Xjg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="KbAIfNQwAUy86VotSmAU7Q" name="ArterialBlood_pls_Stomach_pls" description="Neighborhood between Arterial Blood/Plasma and Stomach/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="Hl-Gd6HA30OOrhWd5UIAVQ" secondNeighbor="gdyMOOU0gkaW4spE0BcIjA">
+              <Tags>
+                <Tag value="Neighborhood: Plasma / Plasma" />
+              </Tags>
+              <Children>
+                <Container id="K4R5_QKWqkSvZzuXFL8Yeg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="6nOpz3nCLkuuZhEVX48CQg" name="Lumen_duo_Duodenum_pls" description="Neighborhood between Lumen/Duodenum and Mucosa/Duodenum/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="Uh4b9ySQo0-IEUYhzejKww" secondNeighbor="qCGoNzAmJUeTktSdRLCDpQ">
+              <Tags>
+                <Tag value="Neighborhood: Duodenum / Plasma" />
+              </Tags>
+              <Children>
+                <Container id="f_HpSUXFg0iwxQ4VUq9F-Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="-UJejCipHkO4MQnKCEeesQ" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="uKzg5qsit06VAeEp5xibnA" isDefault="1" displayUnit="µmol/min">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                    </Parameter>
+                    <Parameter id="h3RXE5jIdk2JwvesgLc3bA" name="Sum of active process rates" description="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="5sKqjuv3WE2Nr_cTaUCUkQ" isDefault="1" displayUnit="µmol/min">
+                      <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                    </Parameter>
+                    <Parameter id="Y-dxml9HM0Cm-dcJepYIlQ" name="Sum of passive process rates" description="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="CxnCjO7-kUCjpt84KomgXw" isDefault="1" displayUnit="µmol/min">
+                      <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                    </Parameter>
+                  </Children>
+                </Container>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="AC4zWD2Zm0mY18VxC290tQ" name="Lumen_duo_Duodenum_cell" description="Neighborhood between Lumen/Duodenum and Mucosa/Duodenum/Intracellular" mode="Logical" containerType="Neighborhood" firstNeighbor="Uh4b9ySQo0-IEUYhzejKww" secondNeighbor="RAm9rDhc0E6uCneMFHfcSQ">
+              <Tags>
+                <Tag value="Neighborhood: Duodenum / Intracellular" />
+              </Tags>
+              <Children>
+                <Container id="3jSyeiYBvUe-FrncNSKL9A" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="YFBGz2hfZ0yAOLfn_7g9Pg" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="q0YooqvoU0qrUqycI7T_vw" isDefault="1" displayUnit="µmol/min">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                    </Parameter>
+                    <Parameter id="-2NDM7QVx0WeMiRHKTMx2Q" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="2vtZBgPdHESzFsyX5jWdxw" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="WAOsBdq2aEqAtvmM5dI60Q" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="J07S_NBj0kuLL902KgFuKg" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="Xof590e0KkS-J139F69jwA" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="U0AqhFZ_qUWTC1_L57WXKQ" isDefault="1">
+                      <Info min="0" flag="36" seq="1" ref="0" bb="2" group="67" />
+                    </Parameter>
+                    <Parameter id="DvQRVQmBeUGVLRa9Po6iQA" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="7F_DufGsVEOpc4M-u4ynzA" isDefault="1">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+                    </Parameter>
+                    <Parameter id="hbecnRaIIUiLu5NUOVG6tQ" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="0acefClmxUSAhyraL0v7UA" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="8_5jbE1cBUy3c1cVFuNPTQ" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="El15YtuX6keaW1PAleyuBQ" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="CZgzHgAfHki9N75b2aBNgQ" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="27eSzHkQ3Umh5UZeqHG6aQ" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="TziFFR8_nUO9jbibZOFWyw" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="MFpVdInbNE-cKxWJrXVfXA" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="jtyplt-Eb0Sml9-vbS1Jcw" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="0b4LjT2SYkCetYN153ppjQ" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="oTJ1EUM-bE2baSh6Je3xJw" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="YzJvRkHMtUeiQyO2fhP81g" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="GSLvnq5SUE2lYCMSJJMvZQ" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Ap07gK_0Pk-62qv7f9OnrQ" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="ZrbUNLveWE6ma98ieRRRZQ" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="nVfYZ66FF0W84y9RBYsn8g" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="oQz_rdoMfk6KpziwUlNUAQ" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="gVsmm42vjUCp5xgwTI9NtA" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="mEce-slKZUemKILtu1AMzw" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="tE3kbrj5vEq-h8ChtOQtHA" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="Vygh5ReoKEuDjfLSR16nAA" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="4dKbSKIcqEOpuVa3g3kiFA" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="iqjcq_JzVE6yGtd5tzLBkA" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Yqc1pqXfwUu4RTTUuBnOMw" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="Sy68A-bkR0iJROCfeBfdXQ" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="kNxHC5F-a0SRE5tzNBa5Tw" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="vBJvc3gaGUmzlScecfBo-A" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="o3bt8HMD8k-qhDrXNRJPKw" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="QXBCHKjypkeTuk5PQQavmQ" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="WBNyhWEmyEq682ssPupytg" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="GQ9HF53HVUG2aUFs7FnfAQ" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="hfJ8fmA9TU-M1chssktruQ" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="0J0Bzf68hUiQEPdUhq9IZg" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="JAt57xHu6068UYo-USk-CQ" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="stMIf3q5MEyO29oS0t_U0A" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CIta8XEcZ0-vg6OK2e7YMg" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="uzaQ-jo7WU2h6PTmzb9Dmg" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ggTKHPU3-ESxtInpiqhz0Q" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="atkm69P-RUeseKYE864uww" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TIMTClcjEkWa2Jrpm18ahQ" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="BkKMCtesn0qYmcLFMy38Gw" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="OSp6wupiGUm1ZDNcKvvKkA" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="QC3JjMSfWEa61s_fvw15XA" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="QGKMNC3BIU-L8isldgY-8A" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="YZ-q2lAumUCLt2Vqn7SxvQ" name="Sum of active process rates" description="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="5sKqjuv3WE2Nr_cTaUCUkQ" isDefault="1" displayUnit="µmol/min">
+                      <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                    </Parameter>
+                    <Parameter id="SqsEI1cL1ke27Wf9PmDZeQ" name="Sum of passive process rates" description="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="CxnCjO7-kUCjpt84KomgXw" isDefault="1" displayUnit="µmol/min">
+                      <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                    </Parameter>
+                  </Children>
+                </Container>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="NlcGsie_PESrB0QIcgCahw" name="Duodenum_pls_PortalVein_pls" description="Neighborhood between Duodenum/Plasma and PortalVein/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="qCGoNzAmJUeTktSdRLCDpQ" secondNeighbor="7wRB5qMJl0aPiDibnmji6g">
+              <Tags>
+                <Tag value="Neighborhood: Plasma / Plasma" />
+              </Tags>
+              <Children>
+                <Container id="Wzp44qPnwkW11vd07m00jw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="C_WeF0-hWkKZLd7wfN0OqA" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="XpzF09V4WECHn0Y8QxGOGA" isDefault="1" displayUnit="µmol/min">
+                      <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                    </Parameter>
+                  </Children>
+                </Container>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="ACy4NeqUWEC4Q1ibp9Z9pw" name="Duodenum_bc_PortalVein_bc" description="Neighborhood between Duodenum/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="r4SZfck0GEir1mEuobAUCg" secondNeighbor="KB1_4NK_sU6lDGk5n9VoOQ">
+              <Tags>
+                <Tag value="Neighborhood: BloodCells / BloodCells" />
+              </Tags>
+              <Children>
+                <Container id="8I8bi3B0FEuvXxymxnMvHA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="nD-CsHxYGU-DKd-lDo8zRw" name="Mass transfer rate (mucosa to portal vein blood cells)" description="Mass transfer rate (mucosa to portal vein blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="8RqexjECt0iuSu_Ga-vZ2Q" isDefault="1" displayUnit="µmol/min">
+                      <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                    </Parameter>
+                  </Children>
+                </Container>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="wRh22mdiDkSHBnlsCkkpPw" name="Lumen_cae_Caecum_pls" description="Neighborhood between Lumen/Cecum and Mucosa/Cecum/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="3tZuU9v7b0uAi8jCQ6JTTQ" secondNeighbor="qukz-ldkCE-evbUN-Ei9Xg">
+              <Tags>
+                <Tag value="Neighborhood: Caecum / Plasma" />
+              </Tags>
+              <Children>
+                <Container id="HCelqiDsfkefMU42Ag2FtA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="KqI5LU-2O0OybcYIDfDRRQ" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="uKzg5qsit06VAeEp5xibnA" isDefault="1" displayUnit="µmol/min">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                    </Parameter>
+                    <Parameter id="88WSWdnxy0On-l3CD-YnEQ" name="Sum of active process rates" description="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="5sKqjuv3WE2Nr_cTaUCUkQ" isDefault="1" displayUnit="µmol/min">
+                      <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                    </Parameter>
+                    <Parameter id="v82fOJRyZ0agkck38bCbuQ" name="Sum of passive process rates" description="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="CxnCjO7-kUCjpt84KomgXw" isDefault="1" displayUnit="µmol/min">
+                      <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                    </Parameter>
+                  </Children>
+                </Container>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="LcWg5dNNr0aKHg8Mw732FA" name="Lumen_cae_Caecum_cell" description="Neighborhood between Lumen/Cecum and Mucosa/Cecum/Intracellular" mode="Logical" containerType="Neighborhood" firstNeighbor="3tZuU9v7b0uAi8jCQ6JTTQ" secondNeighbor="_AgQRAoUBU-0UiC2NRNm0w">
+              <Tags>
+                <Tag value="Neighborhood: Caecum / Intracellular" />
+              </Tags>
+              <Children>
+                <Container id="r4hOIymlIk-ndwf-M9kDgg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="wryJVJ9hgEqfp1bat5Do1g" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="q0YooqvoU0qrUqycI7T_vw" isDefault="1" displayUnit="µmol/min">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                    </Parameter>
+                    <Parameter id="iAXHcPOig0ibN1TEU3mJ6w" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="2vtZBgPdHESzFsyX5jWdxw" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="TVHUqrNQH0eZY5Nm2H3YVQ" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="J07S_NBj0kuLL902KgFuKg" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="kkSqAU_P6E-YVUgJOGNUgg" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ZNeZxFCcP0CMDsWUgwUl2Q" isDefault="1">
+                      <Info min="0" flag="36" seq="1" ref="0" bb="2" group="67" />
+                    </Parameter>
+                    <Parameter id="UrOPM6DAwk-tW_rUYeZ2NA" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="osdNWuX4QEikDU9ruSGldA" isDefault="1">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+                    </Parameter>
+                    <Parameter id="CK61aYPOZkS3nuVaadN_fw" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="0acefClmxUSAhyraL0v7UA" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="rdYaGeAyxE2XEs3Km6UTcg" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="El15YtuX6keaW1PAleyuBQ" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="WQf9f_4ETkmbZY9I2RTZbg" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="27eSzHkQ3Umh5UZeqHG6aQ" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="GmYUir6sa0GmN49c9MWnyQ" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="MFpVdInbNE-cKxWJrXVfXA" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="gcglNiIRp0yL1BJh4_48Fg" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="0b4LjT2SYkCetYN153ppjQ" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="LmK66608EUS1YjHB8H-aIQ" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="YzJvRkHMtUeiQyO2fhP81g" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="SLMmMiMw7ESf2h5SbcfF6A" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Ap07gK_0Pk-62qv7f9OnrQ" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="6uaSqQlEyEiuN2NI1RWNeQ" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="nVfYZ66FF0W84y9RBYsn8g" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="53zu7uwHq0SLeZg4rZTe6Q" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="gVsmm42vjUCp5xgwTI9NtA" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="Vf6GuPBs40ahnlDGjrKJ9g" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="tE3kbrj5vEq-h8ChtOQtHA" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="S-3GIwNbnEaqd6b5jpVj4A" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="4dKbSKIcqEOpuVa3g3kiFA" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="uJ4WqHK4dUOAiD0DeJAlwA" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Yqc1pqXfwUu4RTTUuBnOMw" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="D365J1DMT0iXVblFvwX0LQ" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="kNxHC5F-a0SRE5tzNBa5Tw" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="y-Yjgc-HGUGWB7uKk3GsHg" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="o3bt8HMD8k-qhDrXNRJPKw" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="oo5puzwkz0mcQfR96kukHQ" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="WBNyhWEmyEq682ssPupytg" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="zZGmH0o9h0CvVE3M54K0QA" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="hfJ8fmA9TU-M1chssktruQ" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="_Iyd69j0cEq0v6jWiG731Q" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="JAt57xHu6068UYo-USk-CQ" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="6pYGKJsvqEeKow1wL62NhQ" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CIta8XEcZ0-vg6OK2e7YMg" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="BMvq-qb3w02tH5eR8Df6lw" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ggTKHPU3-ESxtInpiqhz0Q" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="luokRYdS5EWOH8hY0FuO6g" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TIMTClcjEkWa2Jrpm18ahQ" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="9_zw1bmrUkyl2AhibMBZPQ" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="OSp6wupiGUm1ZDNcKvvKkA" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="0oZ0zh1N80iMT-hBWwvSug" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="QGKMNC3BIU-L8isldgY-8A" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="_JcuTrCl4UatbAIukiN3Rg" name="Sum of active process rates" description="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="5sKqjuv3WE2Nr_cTaUCUkQ" isDefault="1" displayUnit="µmol/min">
+                      <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                    </Parameter>
+                    <Parameter id="rFi5MjqPDEWwiY64pDGebA" name="Sum of passive process rates" description="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="CxnCjO7-kUCjpt84KomgXw" isDefault="1" displayUnit="µmol/min">
+                      <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                    </Parameter>
+                  </Children>
+                </Container>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="id-8OubDxkiaCmBRirrQyA" name="Caecum_pls_PortalVein_pls" description="Neighborhood between Cecum/Plasma and PortalVein/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="qukz-ldkCE-evbUN-Ei9Xg" secondNeighbor="7wRB5qMJl0aPiDibnmji6g">
+              <Tags>
+                <Tag value="Neighborhood: Plasma / Plasma" />
+              </Tags>
+              <Children>
+                <Container id="LbFCZUR7sUaKoHj7eG9XgA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="Atjk2qdCqUeGxAlK1DrPrw" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="XpzF09V4WECHn0Y8QxGOGA" isDefault="1" displayUnit="µmol/min">
+                      <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                    </Parameter>
+                  </Children>
+                </Container>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="LKfUt9NKjUOWqIfYnrBOuw" name="Caecum_bc_PortalVein_bc" description="Neighborhood between Cecum/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="6EXMi4P7Zk--PviGX-m75Q" secondNeighbor="KB1_4NK_sU6lDGk5n9VoOQ">
+              <Tags>
+                <Tag value="Neighborhood: BloodCells / BloodCells" />
+              </Tags>
+              <Children>
+                <Container id="5_JxqyM7tkOC2qttamDTkQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="tt53dFyg60OO6eK7wdICTA" name="Mass transfer rate (mucosa to portal vein blood cells)" description="Mass transfer rate (mucosa to portal vein blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="8RqexjECt0iuSu_Ga-vZ2Q" isDefault="1" displayUnit="µmol/min">
+                      <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                    </Parameter>
+                  </Children>
+                </Container>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="Tes-Nt69pkOrU0JfaOrNlQ" name="Lumen_colasc_ColonAscendens_pls" description="Neighborhood between Lumen/Colon Ascendens and Mucosa/Colon Ascendens/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="YMbLwVT-lkaxj25aTkoiQg" secondNeighbor="nddA3OCFX0GdKSVDib1zbQ">
+              <Tags>
+                <Tag value="Neighborhood: ColonAscendens / Plasma" />
+              </Tags>
+              <Children>
+                <Container id="DNgr8OsuAUiN9y5r7AxoWA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="0lgGuFc45EiMA8Vj6hKwNQ" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="uKzg5qsit06VAeEp5xibnA" isDefault="1" displayUnit="µmol/min">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                    </Parameter>
+                    <Parameter id="-bZnGA4XIUexyoWllcmR6g" name="Sum of active process rates" description="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="5sKqjuv3WE2Nr_cTaUCUkQ" isDefault="1" displayUnit="µmol/min">
+                      <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                    </Parameter>
+                    <Parameter id="IGTPv-JT8ESY4SQG0vkO7A" name="Sum of passive process rates" description="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="CxnCjO7-kUCjpt84KomgXw" isDefault="1" displayUnit="µmol/min">
+                      <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                    </Parameter>
+                  </Children>
+                </Container>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="inasUc-WmECVCOwuqw0wgA" name="Lumen_colasc_ColonAscendens_cell" description="Neighborhood between Lumen/Colon Ascendens and Mucosa/Colon Ascendens/Intracellular" mode="Logical" containerType="Neighborhood" firstNeighbor="YMbLwVT-lkaxj25aTkoiQg" secondNeighbor="mI0h7BjrzU2jay0BKO-pig">
+              <Tags>
+                <Tag value="Neighborhood: ColonAscendens / Intracellular" />
+              </Tags>
+              <Children>
+                <Container id="5dTvJrdNckCKwsn6f3aLnw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="l9Ume_ijTk-PPLKlYMFixw" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="q0YooqvoU0qrUqycI7T_vw" isDefault="1" displayUnit="µmol/min">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                    </Parameter>
+                    <Parameter id="XdWDNvsYREa8m-QJ3gfsaA" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="2vtZBgPdHESzFsyX5jWdxw" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="e_Z_MCIc3Ueap2pfwJHNzw" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="J07S_NBj0kuLL902KgFuKg" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="yRf89H51VEujct1mIOQQXA" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TprvG8cZuE-04CvDlyTCxg" isDefault="1">
+                      <Info min="0" flag="36" seq="1" ref="0" bb="2" group="67" />
+                    </Parameter>
+                    <Parameter id="lhGe5SsxnkCFFPNPYAdTxg" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Z9GWRmCZpEm9boCUwMtsmQ" isDefault="1">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+                    </Parameter>
+                    <Parameter id="5J6BgOsAnkquQPKg9TEGgw" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="0acefClmxUSAhyraL0v7UA" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="S9L4vdQxWkWWPSjPrCHTPw" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="El15YtuX6keaW1PAleyuBQ" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="2hRBaynT-kiZlFLZcXguDw" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="27eSzHkQ3Umh5UZeqHG6aQ" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="1-I3okOxs0e3vZoTk-ouZQ" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="MFpVdInbNE-cKxWJrXVfXA" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="gbMtUrFTU0KMKDOpzNBcuQ" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="0b4LjT2SYkCetYN153ppjQ" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="mOzcV-1TjUuoRYZ1UtGWrg" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="YzJvRkHMtUeiQyO2fhP81g" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="-TwjQrvT3UuM3RGgCk7TdA" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Ap07gK_0Pk-62qv7f9OnrQ" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="uSwnGcjTC0OmKmlrEo-eGA" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="nVfYZ66FF0W84y9RBYsn8g" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="eNLPnMfSX0OjhJPl0vt3fQ" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="gVsmm42vjUCp5xgwTI9NtA" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="B5N9qAT2FkqljIstCFlg2A" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="tE3kbrj5vEq-h8ChtOQtHA" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="-QR32bfDjUWmda3Njl4Tnw" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="4dKbSKIcqEOpuVa3g3kiFA" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="36D27PGPhkaHQdasAIssbA" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Yqc1pqXfwUu4RTTUuBnOMw" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="vC29_zD3qU-s9z4-m9MejQ" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="kNxHC5F-a0SRE5tzNBa5Tw" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="3oNi93y9cECrkVqnHk5uqw" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="o3bt8HMD8k-qhDrXNRJPKw" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="R52HmPajak2xV_4C1lSUjw" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="WBNyhWEmyEq682ssPupytg" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="QgOULexN0U-yg6KwEl2EcA" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="hfJ8fmA9TU-M1chssktruQ" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="sBfj0uapCkySGDviiqv5Fw" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="JAt57xHu6068UYo-USk-CQ" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="d65Z6AyVo06o73CJrjBJlg" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CIta8XEcZ0-vg6OK2e7YMg" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="mRCv8dUa-EKiIQkygY6zKg" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ggTKHPU3-ESxtInpiqhz0Q" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="rVm6fMKpnk-JxP7ZLwtgGg" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TIMTClcjEkWa2Jrpm18ahQ" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="bt26LhA5-0qozqEpTKuTxA" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="OSp6wupiGUm1ZDNcKvvKkA" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="nhAED2UamkmX6iG3NgIZfA" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="QGKMNC3BIU-L8isldgY-8A" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="f3CulQXEn0CjslkC5AHzjQ" name="Sum of active process rates" description="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="5sKqjuv3WE2Nr_cTaUCUkQ" isDefault="1" displayUnit="µmol/min">
+                      <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                    </Parameter>
+                    <Parameter id="5zFNAsyR0EGX1Rk6u9M0aA" name="Sum of passive process rates" description="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="CxnCjO7-kUCjpt84KomgXw" isDefault="1" displayUnit="µmol/min">
+                      <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                    </Parameter>
+                  </Children>
+                </Container>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="2QpftStfvE-EFgU9fj3YlA" name="ColonAscendens_pls_PortalVein_pls" description="Neighborhood between Colon Ascendens/Plasma and PortalVein/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="nddA3OCFX0GdKSVDib1zbQ" secondNeighbor="7wRB5qMJl0aPiDibnmji6g">
+              <Tags>
+                <Tag value="Neighborhood: Plasma / Plasma" />
+              </Tags>
+              <Children>
+                <Container id="xhDV_vYOh0G4Q7DlfBQmMA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="TAV4fquSSUW3Y0tl_tAzJQ" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="XpzF09V4WECHn0Y8QxGOGA" isDefault="1" displayUnit="µmol/min">
+                      <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                    </Parameter>
+                  </Children>
+                </Container>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="VpbBDwOMYEK30zGYiU8I4w" name="ColonAscendens_bc_PortalVein_bc" description="Neighborhood between Colon Ascendens/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="lFy3o88xskuHqY8VQAn88Q" secondNeighbor="KB1_4NK_sU6lDGk5n9VoOQ">
+              <Tags>
+                <Tag value="Neighborhood: BloodCells / BloodCells" />
+              </Tags>
+              <Children>
+                <Container id="B7fGDhsdLk22uCrvx5QpBQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="xCvwaWOeu0iynkrSeViI2w" name="Mass transfer rate (mucosa to portal vein blood cells)" description="Mass transfer rate (mucosa to portal vein blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="8RqexjECt0iuSu_Ga-vZ2Q" isDefault="1" displayUnit="µmol/min">
+                      <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                    </Parameter>
+                  </Children>
+                </Container>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="NhM9SgrVTUOcsGe_IvQgGA" name="Lumen_coltrans_ColonTransversum_pls" description="Neighborhood between Lumen/Colon Transversum and Mucosa/Colon Transversum/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="DdIHOXwYBUCq93VVa5oJ7g" secondNeighbor="cSWtcUReDEOC_vr4QwkFJA">
+              <Tags>
+                <Tag value="Neighborhood: ColonTransversum / Plasma" />
+              </Tags>
+              <Children>
+                <Container id="TLyecSXVcESSxdOGuZO2sg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="iP4eZFclkke9_fRbNoCTtw" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="uKzg5qsit06VAeEp5xibnA" isDefault="1" displayUnit="µmol/min">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                    </Parameter>
+                    <Parameter id="HnobCc3XTkykyswslXZLOQ" name="Sum of active process rates" description="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="5sKqjuv3WE2Nr_cTaUCUkQ" isDefault="1" displayUnit="µmol/min">
+                      <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                    </Parameter>
+                    <Parameter id="pqSN8bFGvUycNLOQcKcnCw" name="Sum of passive process rates" description="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="CxnCjO7-kUCjpt84KomgXw" isDefault="1" displayUnit="µmol/min">
+                      <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                    </Parameter>
+                  </Children>
+                </Container>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="T5QVRcYguEq3Ad8BvXsgqg" name="Lumen_coltrans_ColonTransversum_cell" description="Neighborhood between Lumen/Colon Transversum and Mucosa/Colon Transversum/Intracellular" mode="Logical" containerType="Neighborhood" firstNeighbor="DdIHOXwYBUCq93VVa5oJ7g" secondNeighbor="rFBqnzSBzUej0jy-NJYHwQ">
+              <Tags>
+                <Tag value="Neighborhood: ColonTransversum / Intracellular" />
+              </Tags>
+              <Children>
+                <Container id="_6vXzv6ogky_XcZbmnN-1Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="IKNhiKyocE2wpyU37YEMkw" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="q0YooqvoU0qrUqycI7T_vw" isDefault="1" displayUnit="µmol/min">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                    </Parameter>
+                    <Parameter id="PzX6bW_zR02RezxKqVJFvQ" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="2vtZBgPdHESzFsyX5jWdxw" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="labVpwED5kOG0qjzYojijg" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="J07S_NBj0kuLL902KgFuKg" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="MaBj6eHeQ0KdLCnpRqLFhg" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="rNJHRI6hfkejQ5usY15RHA" isDefault="1">
+                      <Info min="0" flag="36" seq="1" ref="0" bb="2" group="67" />
+                    </Parameter>
+                    <Parameter id="kTovxR6FFEePKSgqwJSoxw" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Nnw5WD4aDk-5PIoVOcD1gQ" isDefault="1">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+                    </Parameter>
+                    <Parameter id="ua0uleVUyEiWcW1TupWchw" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="0acefClmxUSAhyraL0v7UA" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="FLs9WwbR-Uma27V-PZ9ejQ" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="El15YtuX6keaW1PAleyuBQ" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="O2QuUAu9UUKU0tTH0cGGtA" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="27eSzHkQ3Umh5UZeqHG6aQ" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="NdjwtrMWK0anzTKC876lYA" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="MFpVdInbNE-cKxWJrXVfXA" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="s7lgYhxKoUiffofmoh_b7g" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="0b4LjT2SYkCetYN153ppjQ" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="yLLezf7D3Uy04SE-DaK15A" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="YzJvRkHMtUeiQyO2fhP81g" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="kz9iN3BEV0-0i7SV7U9JxQ" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Ap07gK_0Pk-62qv7f9OnrQ" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="v9iZ_qzOh0Cl3xgaR6QHxA" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="nVfYZ66FF0W84y9RBYsn8g" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="Yd7oBoA-nU274RRVCa9pUg" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="gVsmm42vjUCp5xgwTI9NtA" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="TqFqepqhWkK9XRoYPh8jFQ" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="tE3kbrj5vEq-h8ChtOQtHA" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="4dpUYXiU3ESQdQSBVS43ew" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="4dKbSKIcqEOpuVa3g3kiFA" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="t3NEdFQhJEObBh39upBchw" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Yqc1pqXfwUu4RTTUuBnOMw" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="CEUViydQdUm96c3rl9eh7Q" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="kNxHC5F-a0SRE5tzNBa5Tw" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="PGOkAD6YoUGBYgSuCNDtGQ" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="o3bt8HMD8k-qhDrXNRJPKw" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="Ss7y31MdskaY6TTTybiH9g" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="WBNyhWEmyEq682ssPupytg" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="dqyI1yGYcEm8k2uFY-GAIg" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="hfJ8fmA9TU-M1chssktruQ" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="4Qz6HcpRm0GV6FBjVeQuwA" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="JAt57xHu6068UYo-USk-CQ" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="5MEerfNOwUCJzvrVbaN41w" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CIta8XEcZ0-vg6OK2e7YMg" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="Z9mbImfy6k2UgSNUnnt0_Q" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ggTKHPU3-ESxtInpiqhz0Q" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="wbLwgMubWkGSQDPqkdYy2w" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TIMTClcjEkWa2Jrpm18ahQ" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="f-xuYm-zcEC1-fxJCR6tvA" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="OSp6wupiGUm1ZDNcKvvKkA" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="3_9-JDmrkk25PFSsrBXaKQ" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="QGKMNC3BIU-L8isldgY-8A" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="yeWOPAudhU-vudUSvvwIig" name="Sum of active process rates" description="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="5sKqjuv3WE2Nr_cTaUCUkQ" isDefault="1" displayUnit="µmol/min">
+                      <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                    </Parameter>
+                    <Parameter id="lcmq_cEzXU2uf9vqTNdo3A" name="Sum of passive process rates" description="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="CxnCjO7-kUCjpt84KomgXw" isDefault="1" displayUnit="µmol/min">
+                      <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                    </Parameter>
+                  </Children>
+                </Container>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="QdGAj6l8qEO3pFn-B6H_7A" name="ColonTransversum_pls_PortalVein_pls" description="Neighborhood between Colon Transversum/Plasma and PortalVein/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="cSWtcUReDEOC_vr4QwkFJA" secondNeighbor="7wRB5qMJl0aPiDibnmji6g">
+              <Tags>
+                <Tag value="Neighborhood: Plasma / Plasma" />
+              </Tags>
+              <Children>
+                <Container id="or7fUs-0Nk64MMJts6S9hQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="MFbQ-vLu6EmJotjEKcUVCg" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="XpzF09V4WECHn0Y8QxGOGA" isDefault="1" displayUnit="µmol/min">
+                      <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                    </Parameter>
+                  </Children>
+                </Container>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="UytD1r9-t0a00zwgQc0EfQ" name="ColonTransversum_bc_PortalVein_bc" description="Neighborhood between Colon Transversum/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="9tf7XE_EBkqMwcotfbazmQ" secondNeighbor="KB1_4NK_sU6lDGk5n9VoOQ">
+              <Tags>
+                <Tag value="Neighborhood: BloodCells / BloodCells" />
+              </Tags>
+              <Children>
+                <Container id="oBgB7Z7OhUy2JHnMrZF4lQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="PF0pDA4KEkKW30CoLGlQLA" name="Mass transfer rate (mucosa to portal vein blood cells)" description="Mass transfer rate (mucosa to portal vein blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="8RqexjECt0iuSu_Ga-vZ2Q" isDefault="1" displayUnit="µmol/min">
+                      <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                    </Parameter>
+                  </Children>
+                </Container>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="Fg6yVhLzFEK4VnTVvm-GOQ" name="Lumen_coldesc_ColonDescendens_pls" description="Neighborhood between Lumen/Colon Descendens and Mucosa/Colon Descendens/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="ibG_MtDU_UeUGcopqh_FaQ" secondNeighbor="pIzMA-eWSUisOrBZ-cC5jw">
+              <Tags>
+                <Tag value="Neighborhood: ColonDescendens / Plasma" />
+              </Tags>
+              <Children>
+                <Container id="PnINy0OmZEGEDWfqIl8J9A" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="Wh5BvHItn0G_seT7guVRZw" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="uKzg5qsit06VAeEp5xibnA" isDefault="1" displayUnit="µmol/min">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                    </Parameter>
+                    <Parameter id="BOAFXS-cPUSljcSlPivn-A" name="Sum of active process rates" description="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="5sKqjuv3WE2Nr_cTaUCUkQ" isDefault="1" displayUnit="µmol/min">
+                      <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                    </Parameter>
+                    <Parameter id="UApkK0dFnkiDo6Rsi7BTZw" name="Sum of passive process rates" description="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="CxnCjO7-kUCjpt84KomgXw" isDefault="1" displayUnit="µmol/min">
+                      <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                    </Parameter>
+                  </Children>
+                </Container>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="p0n4QGhSOECxSkFaBovOOw" name="Lumen_coldesc_ColonDescendens_cell" description="Neighborhood between Lumen/Colon Descendens and Mucosa/Colon Descendens/Intracellular" mode="Logical" containerType="Neighborhood" firstNeighbor="ibG_MtDU_UeUGcopqh_FaQ" secondNeighbor="zsiyKimiGEeUQIIZc604yg">
+              <Tags>
+                <Tag value="Neighborhood: ColonDescendens / Intracellular" />
+              </Tags>
+              <Children>
+                <Container id="oaR3iORwoUiUjmPDIxYOoQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="xVd3UprxlUyFB029KGwNLg" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="q0YooqvoU0qrUqycI7T_vw" isDefault="1" displayUnit="µmol/min">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                    </Parameter>
+                    <Parameter id="QmswK87BxEiTtlqZJ7ohQA" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="2vtZBgPdHESzFsyX5jWdxw" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="8uaa_W-wAEGI1mwPxixpnw" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="J07S_NBj0kuLL902KgFuKg" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="9FobCHfwX0-FFG5e4oqB1w" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="NV_LugAaI0CZIFIJeyqf_w" isDefault="1">
+                      <Info min="0" flag="36" seq="1" ref="0" bb="2" group="67" />
+                    </Parameter>
+                    <Parameter id="BJPkKsUjckOAtnr46wBCqg" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="RBHQyXiDU0ewL1I1y21WdA" isDefault="1">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+                    </Parameter>
+                    <Parameter id="zkr9OSEzn0ybTGZfbV-ekQ" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="0acefClmxUSAhyraL0v7UA" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="YuCBi_X2yUam3KnF9Bhvhw" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="El15YtuX6keaW1PAleyuBQ" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="m71nEVOPvE6fRiaq0Wqpng" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="27eSzHkQ3Umh5UZeqHG6aQ" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="5C8o5ErkQ0CW41o3v1vUfw" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="MFpVdInbNE-cKxWJrXVfXA" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="OXgnCLXV6kuZDUF-ti7rfA" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="0b4LjT2SYkCetYN153ppjQ" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="wDKDx72yBkCLQ0yDnb9hCA" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="YzJvRkHMtUeiQyO2fhP81g" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="6qw4mATgx0aOijayZJFjFA" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Ap07gK_0Pk-62qv7f9OnrQ" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="9ML9Hin3Wkii3uHXGSVQ7g" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="nVfYZ66FF0W84y9RBYsn8g" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="JnxUfWnWckqS5Dq2CTdsrQ" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="gVsmm42vjUCp5xgwTI9NtA" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="yaXCJgm6GkCBg-HHy0ckTA" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="tE3kbrj5vEq-h8ChtOQtHA" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="BHa3CNEX2kSDygxhQSa0Dw" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="4dKbSKIcqEOpuVa3g3kiFA" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="gF5eqlwtokOF1FejBBdQWQ" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Yqc1pqXfwUu4RTTUuBnOMw" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="ot2z-4gCHEGExZvaFjiiNA" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="kNxHC5F-a0SRE5tzNBa5Tw" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="FEdtxcsOK0CYYpWZnoRoGA" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="o3bt8HMD8k-qhDrXNRJPKw" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="0uWCtqr2nEKP2f6DNnN88A" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="WBNyhWEmyEq682ssPupytg" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="C1SwjzyXKEqgSengWtme1w" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="hfJ8fmA9TU-M1chssktruQ" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="gifu7hW-bEm3rkK3R8yW0g" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="JAt57xHu6068UYo-USk-CQ" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="iBuwc2m1l0ensO3jctSXPA" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CIta8XEcZ0-vg6OK2e7YMg" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="2dufxcL4TUywNPQv0zOAKg" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ggTKHPU3-ESxtInpiqhz0Q" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="TPIMHm1RT0uxYQPSNwZoZA" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TIMTClcjEkWa2Jrpm18ahQ" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="F4985jP7e0iqYEWyaC8kFA" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="OSp6wupiGUm1ZDNcKvvKkA" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="qnnHydrKaEOm6WVXjtf_SQ" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="QGKMNC3BIU-L8isldgY-8A" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="dkENNiMC5USkotuaigqcUQ" name="Sum of active process rates" description="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="5sKqjuv3WE2Nr_cTaUCUkQ" isDefault="1" displayUnit="µmol/min">
+                      <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                    </Parameter>
+                    <Parameter id="dU3hjkh8B0eH8-qk2mKsyA" name="Sum of passive process rates" description="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="CxnCjO7-kUCjpt84KomgXw" isDefault="1" displayUnit="µmol/min">
+                      <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                    </Parameter>
+                  </Children>
+                </Container>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="nx4es-lWoEi08SZeT-Cxiw" name="ColonDescendens_pls_PortalVein_pls" description="Neighborhood between Colon Descendens/Plasma and PortalVein/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="pIzMA-eWSUisOrBZ-cC5jw" secondNeighbor="7wRB5qMJl0aPiDibnmji6g">
+              <Tags>
+                <Tag value="Neighborhood: Plasma / Plasma" />
+              </Tags>
+              <Children>
+                <Container id="wmhckRz3Gk2S2gF0GqC2Cg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="exQ4BwFJfUaJyanTmi3s1Q" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="XpzF09V4WECHn0Y8QxGOGA" isDefault="1" displayUnit="µmol/min">
+                      <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                    </Parameter>
+                  </Children>
+                </Container>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="WAe2RjL9fkeWMVFFvvFtCw" name="ColonDescendens_bc_PortalVein_bc" description="Neighborhood between Colon Descendens/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="b1XobftQwUiN9-8v8K-ffA" secondNeighbor="KB1_4NK_sU6lDGk5n9VoOQ">
+              <Tags>
+                <Tag value="Neighborhood: BloodCells / BloodCells" />
+              </Tags>
+              <Children>
+                <Container id="Yqe72jXGzkyLyg6R__gowg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="cY0d85X8a0CxB9djKVpJcA" name="Mass transfer rate (mucosa to portal vein blood cells)" description="Mass transfer rate (mucosa to portal vein blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="8RqexjECt0iuSu_Ga-vZ2Q" isDefault="1" displayUnit="µmol/min">
+                      <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                    </Parameter>
+                  </Children>
+                </Container>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="UUyXNneUtUmlUBBc_jKUgw" name="Lumen_colsigm_ColonSigmoid_pls" description="Neighborhood between Lumen/Colon Sigmoid and Mucosa/Colon Sigmoid/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="sHZCByHK30-UYnBeZG7BKw" secondNeighbor="NnYDxAvR50id6cKL1JK05A">
+              <Tags>
+                <Tag value="Neighborhood: ColonSigmoid / Plasma" />
+              </Tags>
+              <Children>
+                <Container id="F-L2vZrMDEy4pFthR7Eplw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="p_6Uv5gHUk2D6b-uKDlyMQ" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="uKzg5qsit06VAeEp5xibnA" isDefault="1" displayUnit="µmol/min">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                    </Parameter>
+                    <Parameter id="KE_f99jn_0CtW1El_yTupQ" name="Sum of active process rates" description="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="5sKqjuv3WE2Nr_cTaUCUkQ" isDefault="1" displayUnit="µmol/min">
+                      <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                    </Parameter>
+                    <Parameter id="mK0tVVDVaEmTIamgoqLipg" name="Sum of passive process rates" description="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="CxnCjO7-kUCjpt84KomgXw" isDefault="1" displayUnit="µmol/min">
+                      <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                    </Parameter>
+                  </Children>
+                </Container>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="KmFrraOGlEKj5NjWcXHF_A" name="Lumen_colsigm_ColonSigmoid_cell" description="Neighborhood between Lumen/Colon Sigmoid and Mucosa/Colon Sigmoid/Intracellular" mode="Logical" containerType="Neighborhood" firstNeighbor="sHZCByHK30-UYnBeZG7BKw" secondNeighbor="mN0sgeauwEOO8CBAEY9_3g">
+              <Tags>
+                <Tag value="Neighborhood: ColonSigmoid / Intracellular" />
+              </Tags>
+              <Children>
+                <Container id="y8aDiH-xrkKicZhwAaIXdg" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="9kLDwT-MUUCz0AipVC8yXw" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="q0YooqvoU0qrUqycI7T_vw" isDefault="1" displayUnit="µmol/min">
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                    </Parameter>
+                    <Parameter id="sdzjmTdXlEWrkm7niCQTog" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="2vtZBgPdHESzFsyX5jWdxw" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="Jluep70rUkaGikYri0rPJQ" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="J07S_NBj0kuLL902KgFuKg" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="brjISAycPkavsIExExDQng" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BSJtoYiM70aqYfinS543gw" isDefault="1">
+                      <Info min="0" flag="36" seq="1" ref="0" bb="2" group="67" />
+                    </Parameter>
+                    <Parameter id="csKuIW2qOU-1KySrLf85ig" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DkyscjlThUqSpYNLciZb9Q" isDefault="1">
+                      <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+                    </Parameter>
+                    <Parameter id="s5hlxsO-IE2U-o0D5zqnjA" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="0acefClmxUSAhyraL0v7UA" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="psrxTrh5okSXm-a7IdWktQ" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="El15YtuX6keaW1PAleyuBQ" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="WWhSvvKeX0K3jL3RM3nRqw" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="27eSzHkQ3Umh5UZeqHG6aQ" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="e0jn1-D3rkux5ylbry7xPw" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="MFpVdInbNE-cKxWJrXVfXA" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="__ynx34EyEadR43kEXnfIw" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="0b4LjT2SYkCetYN153ppjQ" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="ZkTa3ueqD06CJaKGl8x38Q" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="YzJvRkHMtUeiQyO2fhP81g" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="uAjSGQ6L30i614zZoLjrAg" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Ap07gK_0Pk-62qv7f9OnrQ" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="SrXK7QMUHEGyHhX4p9T6hQ" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="nVfYZ66FF0W84y9RBYsn8g" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="gks-nQZ5vU6R5EYrQwuaqg" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="gVsmm42vjUCp5xgwTI9NtA" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="ePwwo22K5EObNFph_LoIVA" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="tE3kbrj5vEq-h8ChtOQtHA" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="7fFo4qD_pUuYTOjt56QLuQ" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="4dKbSKIcqEOpuVa3g3kiFA" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="sGXmSYwofUmu71eVc9OBQw" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Yqc1pqXfwUu4RTTUuBnOMw" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="xrVGxkaTsUSfSe0UYNXW7Q" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="kNxHC5F-a0SRE5tzNBa5Tw" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="UfEp9OLHsEeN3LwVDudO1w" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="o3bt8HMD8k-qhDrXNRJPKw" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="X2iKpnaJlU-2_27O6mR40w" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="WBNyhWEmyEq682ssPupytg" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="AK_ZyRWmLEe2PGVL5ZJrpw" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="hfJ8fmA9TU-M1chssktruQ" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="lIuPAyiB0EOLTyNWCVNokw" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="JAt57xHu6068UYo-USk-CQ" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="6iywu6uY-0uY6oUboUMvYQ" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CIta8XEcZ0-vg6OK2e7YMg" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="eu_ukVviWUKFPB9kDnPoWg" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ggTKHPU3-ESxtInpiqhz0Q" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="uGEoEe57Rk-fA54GwDnl5A" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TIMTClcjEkWa2Jrpm18ahQ" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="lJLW3lF98ky0ZaoN27u8zw" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="OSp6wupiGUm1ZDNcKvvKkA" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="Ta3lzQ1snkGZVchdoA0_sQ" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="QGKMNC3BIU-L8isldgY-8A" isDefault="1">
+                      <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                    </Parameter>
+                    <Parameter id="fXeb0X9lv0yL7XrTPXJjXQ" name="Sum of active process rates" description="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="5sKqjuv3WE2Nr_cTaUCUkQ" isDefault="1" displayUnit="µmol/min">
+                      <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                    </Parameter>
+                    <Parameter id="bqDLMlEj9kaeG5a8K7-hRQ" name="Sum of passive process rates" description="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="CxnCjO7-kUCjpt84KomgXw" isDefault="1" displayUnit="µmol/min">
+                      <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                    </Parameter>
+                  </Children>
+                </Container>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="AvYYk5SZ4ke64Dlfm0PFRg" name="ColonSigmoid_pls_PortalVein_pls" description="Neighborhood between Colon Sigmoid/Plasma and PortalVein/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="NnYDxAvR50id6cKL1JK05A" secondNeighbor="7wRB5qMJl0aPiDibnmji6g">
+              <Tags>
+                <Tag value="Neighborhood: Plasma / Plasma" />
+              </Tags>
+              <Children>
+                <Container id="_RuQKLv3TEio-e99tI6-nw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="C3AFYpUOd0OrxbTW4HJsgA" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="XpzF09V4WECHn0Y8QxGOGA" isDefault="1" displayUnit="µmol/min">
+                      <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                    </Parameter>
+                  </Children>
+                </Container>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="_5BzgNWymES9c0lliGt92A" name="ColonSigmoid_bc_PortalVein_bc" description="Neighborhood between Colon Sigmoid/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="9rh5uMJZKkCrCkUcs7GNfA" secondNeighbor="KB1_4NK_sU6lDGk5n9VoOQ">
+              <Tags>
+                <Tag value="Neighborhood: BloodCells / BloodCells" />
+              </Tags>
+              <Children>
+                <Container id="DI9Rnc23hESwOTOYVdgTYQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other">
+                  <Children>
+                    <Parameter id="_TdRVSkLH0-F3zRdkyW60w" name="Mass transfer rate (mucosa to portal vein blood cells)" description="Mass transfer rate (mucosa to portal vein blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="8RqexjECt0iuSu_Ga-vZ2Q" isDefault="1" displayUnit="µmol/min">
+                      <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                      <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                    </Parameter>
+                  </Children>
+                </Container>
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="6SNPtXvq-ES1by4IMlmoiw" name="Duodenum_cell__VenousBlood_pls" description="Neighborhood between SmallIntestine/Mucosa/Duodenum/Interstitial and Venous Blood/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="C7hTSXNAWUyi0kaAzMdxxg" secondNeighbor="OW9eeGpb1Ui7R75zcOETVQ">
+              <Tags>
+                <Tag value="Neighborhood: Interstitial / Plasma" />
+              </Tags>
+              <Children>
+                <Container id="hPS5zxPufEe3mmPkvctNTw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="mtPMCVxJNEi8jap0LpgLbg" name="UpperJejunum_cell__VenousBlood_pls" description="Neighborhood between SmallIntestine/Mucosa/UpperJejunum/Interstitial and Venous Blood/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="v4S0FxtaWUa5mdhk99294A" secondNeighbor="OW9eeGpb1Ui7R75zcOETVQ">
+              <Tags>
+                <Tag value="Neighborhood: Interstitial / Plasma" />
+              </Tags>
+              <Children>
+                <Container id="ygAdSntx5U2n_i0PUz0m4w" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="iaSBK8EQNEmt4wPz3dHpkw" name="LowerJejunum_cell__VenousBlood_pls" description="Neighborhood between SmallIntestine/Mucosa/LowerJejunum/Interstitial and Venous Blood/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="Q4E86CQOH0K7uQpKh7V0fA" secondNeighbor="OW9eeGpb1Ui7R75zcOETVQ">
+              <Tags>
+                <Tag value="Neighborhood: Interstitial / Plasma" />
+              </Tags>
+              <Children>
+                <Container id="DI9BUddRK0u3ZR8mYMt97w" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="DoUOUK8i-UKNoQp-ORtHQA" name="UpperIleum_cell__VenousBlood_pls" description="Neighborhood between SmallIntestine/Mucosa/UpperIleum/Interstitial and Venous Blood/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="8d23X9v4OUO6u2MqRJcTOA" secondNeighbor="OW9eeGpb1Ui7R75zcOETVQ">
+              <Tags>
+                <Tag value="Neighborhood: Interstitial / Plasma" />
+              </Tags>
+              <Children>
+                <Container id="-6LTX-VF8EaOM53fDF3BMw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="n02Zs9XglkypWGrfYEVfqA" name="LowerIleum_cell__VenousBlood_pls" description="Neighborhood between SmallIntestine/Mucosa/LowerIleum/Interstitial and Venous Blood/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="7b85cR4vJ0aGJEWuwq4eQA" secondNeighbor="OW9eeGpb1Ui7R75zcOETVQ">
+              <Tags>
+                <Tag value="Neighborhood: Interstitial / Plasma" />
+              </Tags>
+              <Children>
+                <Container id="5xjWCfi4RkyJfJUMNl7zrw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="xtSRQp3Q7Eyscc2pU-hrUQ" name="Caecum_cell__VenousBlood_pls" description="Neighborhood between LargeIntestine/Mucosa/Cecum/Interstitial and Venous Blood/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="CtrU9WUZf0qEHKEvvammJA" secondNeighbor="OW9eeGpb1Ui7R75zcOETVQ">
+              <Tags>
+                <Tag value="Neighborhood: Interstitial / Plasma" />
+              </Tags>
+              <Children>
+                <Container id="6rChQOIFD0CZ2UyyonRcrw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="putT8Ns0rk-SujyYYsDE-g" name="ColonAscendens_cell__VenousBlood_pls" description="Neighborhood between LargeIntestine/Mucosa/ColonAscendens/Interstitial and Venous Blood/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="g9hqGHJYvkeWOhIzeQpElw" secondNeighbor="OW9eeGpb1Ui7R75zcOETVQ">
+              <Tags>
+                <Tag value="Neighborhood: Interstitial / Plasma" />
+              </Tags>
+              <Children>
+                <Container id="_g_PDHinv0q5aFKXfQ5ixw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="JbyxTYZlXEq6Wpq5kMO36A" name="ColonTransversum_cell__VenousBlood_pls" description="Neighborhood between LargeIntestine/Mucosa/ColonTransversum/Interstitial and Venous Blood/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="7G_St76qx0mqUjrG7nB_fA" secondNeighbor="OW9eeGpb1Ui7R75zcOETVQ">
+              <Tags>
+                <Tag value="Neighborhood: Interstitial / Plasma" />
+              </Tags>
+              <Children>
+                <Container id="4pIFT06_hEa87wR13rSS4Q" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="AokLwsvHTEmWKGA3tfNsOQ" name="ColonDescendens_cell__VenousBlood_pls" description="Neighborhood between LargeIntestine/Mucosa/ColonDescendens/Interstitial and Venous Blood/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="WJhsAHbQDkuE3t4ndWlF_w" secondNeighbor="OW9eeGpb1Ui7R75zcOETVQ">
+              <Tags>
+                <Tag value="Neighborhood: Interstitial / Plasma" />
+              </Tags>
+              <Children>
+                <Container id="6-KodsG8U0Wsnh1muZ8Wng" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="1hZZHBWbz0qtDTdbEj1tHQ" name="ColonSigmoid_cell__VenousBlood_pls" description="Neighborhood between LargeIntestine/Mucosa/ColonSigmoid/Interstitial and Venous Blood/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="-BJYLLzaN0GrVt8nmTiwTQ" secondNeighbor="OW9eeGpb1Ui7R75zcOETVQ">
+              <Tags>
+                <Tag value="Neighborhood: Interstitial / Plasma" />
+              </Tags>
+              <Children>
+                <Container id="wRva_wXLNEGER3RE9tPrGw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="ufwhsXEBsEyM8sn6C06DNg" name="Rectum_cell__VenousBlood_pls" description="Neighborhood between LargeIntestine/Mucosa/Rectum/Interstitial and Venous Blood/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="c6iso5cc4Eu-rSgVPq2QxA" secondNeighbor="OW9eeGpb1Ui7R75zcOETVQ">
+              <Tags>
+                <Tag value="Neighborhood: Interstitial / Plasma" />
+              </Tags>
+              <Children>
+                <Container id="nTTYOHnfy02ApH2CWJg4XA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="UjAgTmalZke-jyUiTKF99w" name="Periportal_pls_Pericentral_pls" description="Neighborhood between Liver/Periportal/Plasma and Liver/Pericentral/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="23PubB3JsEmwt4zxO6YDIw" secondNeighbor="4ON-uIC2yka_hwoIl3K68w">
+              <Children>
+                <Container id="WOvAgQ1LOE6RDtK2jSpDIA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="L3elzWEtpkyJi8QVPl1eEQ" name="Periportal_bc_Pericentral_bc" description="Neighborhood between Liver/Periportal/Blood Cells and Liver/Pericentral/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="gN_9yZiLj0uUZO_KvTppTg" secondNeighbor="5bZh8mQG10-PXIrw1ZTguw">
+              <Children>
+                <Container id="EKpAv19ek0mpotfQ7t4ung" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="qvIg2e1BH0uUSWWEdIW74A" name="ArterialBlood_bc_Periportal_bc" description="Neighborhood between Arterial Blood/Blood Cells and Liver/Periportal/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="bE0VJ8a31Uyaciw1C0jzTg" secondNeighbor="gN_9yZiLj0uUZO_KvTppTg">
+              <Tags>
+                <Tag value="Neighborhood: BloodCells / BloodCells" />
+              </Tags>
+              <Children>
+                <Container id="ux-V9I7kt0afdt1Y-NGycQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="VWR3Hmza9keDNAJ3vIYu2w" name="ArterialBlood_pls_Periportal_pls" description="Neighborhood between Arterial Blood/Plasma and Liver/Periportal/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="Hl-Gd6HA30OOrhWd5UIAVQ" secondNeighbor="23PubB3JsEmwt4zxO6YDIw">
+              <Tags>
+                <Tag value="Neighborhood: Plasma / Plasma" />
+              </Tags>
+              <Children>
+                <Container id="ud_xAnjKTU6gXzXuOqNQ2g" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="yxdMk3q7pU6Z8_mAlVA51Q" name="PortalVein_bc_Periportal_bc" description="Neighborhood between Portal Vein/Blood Cells and Liver/Periportal/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="KB1_4NK_sU6lDGk5n9VoOQ" secondNeighbor="gN_9yZiLj0uUZO_KvTppTg">
+              <Tags>
+                <Tag value="Neighborhood: BloodCells / BloodCells" />
+              </Tags>
+              <Children>
+                <Container id="cgRmbbkf00KOfvOxegjAHA" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="D8dSmiefsE2Ae2MCKVVwSg" name="PortalVein_pls_Periportal_pls" description="Neighborhood between Portal Vein/Plasma and Liver/Periportal/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="7wRB5qMJl0aPiDibnmji6g" secondNeighbor="23PubB3JsEmwt4zxO6YDIw">
+              <Tags>
+                <Tag value="Neighborhood: Plasma / Plasma" />
+              </Tags>
+              <Children>
+                <Container id="TCDCxUmY3UGdfWna4oNYRw" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="8UhjpBBQr0O94Aj_xC7LhA" name="Pericentral_bc_VenousBlood_bc" description="Neighborhood between Liver/Pericentral/Blood Cells and Venous Blood/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="5bZh8mQG10-PXIrw1ZTguw" secondNeighbor="Psihdre1OUqL7biUDEcQDw">
+              <Tags>
+                <Tag value="Neighborhood: BloodCells / BloodCells" />
+              </Tags>
+              <Children>
+                <Container id="rJcHMnQCfUqR33daQ9PnRQ" name="MoleculeProperties" description="Molecule dependent properties" mode="Logical" containerType="Other" />
+              </Children>
+            </NeighborhoodBuilder>
+            <NeighborhoodBuilder id="1dBIIk9xQEik9BVa--RFdw" name="Periportal_bc_VenousBlood_bc" description="Neighborhood between Liver/Periportal/Blood Cells and Venous Blood/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="gN_9yZiLj0uUZO_KvTppTg" secondNeighbor="Psihdre1OUqL7biUDEcQDw">
+              <Tags>
+                <Tag value="Neighborhood: BloodCells / BloodCells" />
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+            <Formula id="Y7-g6OZD1EuWOoCTEko_zg" name="PARAM_VolumeGutWall_UpperIleum" dim="Volume" formula="V_Intestine * 0.324">
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+                <Path path="367" as="368" dim="55" />
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+              <Paths>
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+            <Formula id="WYe41mNVfke4hs7izFNiWg" name="PARAM_InverseLITT_Factor_Caecum" dim="Inversed time" formula="LuminalVelocity/LITT_fact">
+              <Paths>
+                <Path path="343" as="344" dim="50" />
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+            <Formula id="tkkmnR4PcEKvkN0VdR6LWQ" name="PARAM_Outflow_ColonAscendens" dim="Inversed time" formula="(k_p*alpha_p*V_p+inflow-k*alpha*V)/(alpha*V)">
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+            <Formula id="s5HpSDrASUmW41jK-GT_BA" name="PARAM_InverseLITT_Factor_ColonAscendens" dim="Inversed time" formula="LuminalVelocity/LITT_fact">
+              <Paths>
+                <Path path="343" as="344" dim="50" />
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+            <Formula id="vOTTAch-OEGoFu6F7CTb8g" name="PARAM_LiquidTransferRate_colasc" dim="Flow" formula="w*Liquid*FillLevelFlagNext">
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+            <Formula id="C4gfI3l89kqHL4-iH81OrA" name="PARAM_VolumeGutWall_ColonAscendens" dim="Volume" formula="V_Intestine * 0.15529412">
+              <Paths>
+                <Path path="426" as="368" dim="55" />
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+            <Formula id="CbHBIDCd9UCPiyObpHz4Qg" name="PARAM_OralMassAbsorbed_RHS_colasc" dim="Amount per time" formula="PassiveRates_para+PassiveRates_trans-(ActiveRates_para+ActiveRates_trans)">
+              <Paths>
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+            <Formula id="kaRDWceerUqXWaP-qgl_Zw" name="PARAM_Outflow_ColonTransversum" dim="Inversed time" formula="(k_p*alpha_p*V_p+inflow-k*alpha*V)/(alpha*V)">
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+            <Formula id="mEVcDlLaEUyG_BDTgYh8SA" name="PARAM_InverseLITT_Factor_ColonTransversum" dim="Inversed time" formula="LuminalVelocity/LITT_fact">
+              <Paths>
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+            <Formula id="RELbaq49qUGJXrbr3kuQOw" name="LiquidRHS_coltrans" dim="Flow" formula="OralApplicationsEnabled ? LT_colasc - LT_coltrans + Inflow*FillLevelFlag - Outflow*Liquid : 0">
+              <Paths>
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+            <Formula id="g19pbO_laECIzd7DRmXOdg" name="PARAM_LiquidTransferRate_coltrans" dim="Flow" formula="w*Liquid*FillLevelFlagNext">
+              <Paths>
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+            <Formula id="5hePi0UqyE6Ygu16w_2Lkg" name="PARAM_VolumeGutWall_ColonTransversum" dim="Volume" formula="V_Intestine * 0.32">
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+            <Formula id="tE6JJ0II20GjJxIWCo0Q_w" name="PARAM_OralMassAbsorbed_RHS_coltrans" dim="Amount per time" formula="PassiveRates_para+PassiveRates_trans-(ActiveRates_para+ActiveRates_trans)">
+              <Paths>
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+            <Formula id="N4ZfBaP0bU-p4Pl3Ll_Yqw" name="PARAM_Outflow_ColonDescendens" dim="Inversed time" formula="(k_p*alpha_p*V_p+inflow-k*alpha*V)/(alpha*V)">
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+            <Formula id="px_qW122EkCCS1Nz_R6apQ" name="PARAM_InverseLITT_Factor_ColonDescendens" dim="Inversed time" formula="LuminalVelocity/LITT_fact">
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+                <Path path="343" as="344" dim="50" />
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+            <Formula id="gRiD_7x45EiTKZ2w71cH1g" name="PARAM_LiquidTransferRate_coldesc" dim="Flow" formula="w*Liquid*FillLevelFlagNext">
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+            <Formula id="kxBpcZGfcEGzcmmTT6XQeQ" name="PARAM_Inflow_ColonDescendens" dim="Flow" formula="0.00023004*V">
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+            <Formula id="zKCZTaZMz0K5ME2MfwwBOQ" name="PARAM_VolumeGutWall_ColonDescendens" dim="Volume" formula="V_Intestine * 0.24">
+              <Paths>
+                <Path path="426" as="368" dim="55" />
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+            <Formula id="QxPqChOxWESqUe5UyDSWZA" name="PARAM_OralMassAbsorbed_RHS_coldesc" dim="Amount per time" formula="PassiveRates_para+PassiveRates_trans-(ActiveRates_para+ActiveRates_trans)">
+              <Paths>
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+            <Formula id="_NYTLA4Z9EqF_4Ey-92V1g" name="PARAM_Outflow_ColonSigmoid" dim="Inversed time" formula="(k_p*alpha_p*V_p+inflow-k*alpha*V)/(alpha*V)">
+              <Paths>
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+            <Formula id="ByGPV9JXx0aPWfyujly96Q" name="PARAM_InverseLITT_Factor_ColonSigmoid" dim="Inversed time" formula="LuminalVelocity/LITT_fact">
+              <Paths>
+                <Path path="343" as="344" dim="50" />
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+            <Formula id="pVrB4n2orkeZo884nOsnzQ" name="LiquidRHS_colsigm" dim="Flow" formula="OralApplicationsEnabled ? LT_coldesc - LT_colsigm + Inflow*FillLevelFlag - Outflow*Liquid : 0">
+              <Paths>
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+            <Formula id="wjvuZK2IikWXh8-tLT2QfQ" name="PARAM_LiquidTransferRate_colsigm" dim="Flow" formula="w*Liquid*FillLevelFlagNext">
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+            <Formula id="fLYIYkz90UKr1KVsTab17w" name="PARAM_Inflow_ColonSigmoid" dim="Flow" formula="0.00013099*V">
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+            <Formula id="UA3XKc6iSkSbkyNGUHcV9w" name="PARAM_VolumeGutWall_ColonSigmoid" dim="Volume" formula="V_Intestine * 0.135">
+              <Paths>
+                <Path path="426" as="368" dim="55" />
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+            <Formula id="ubEQZdDX70KP_Q2t_IBukg" name="PARAM_OralMassAbsorbed_RHS_colsigm" dim="Amount per time" formula="PassiveRates_para+PassiveRates_trans-(ActiveRates_para+ActiveRates_trans)">
+              <Paths>
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+            <Formula id="j2zBPMNj2UyPphylX_iJsw" name="PARAM_Outflow_Rectum" dim="Inversed time" formula="(k_p*alpha_p*V_p+inflow-k*alpha*V)/(alpha*V)">
+              <Paths>
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+            <Formula id="ZoJ7916bgk-CCc3Q9yMNJg" name="PARAM_InverseLITT_Factor_Rectum" dim="Inversed time" formula="LuminalVelocity/LITT_fact">
+              <Paths>
+                <Path path="343" as="344" dim="50" />
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+            <Formula id="8wQlrsXdfkW-Ex6bAsDELw" name="LiquidRHS_rect" dim="Flow" formula="OralApplicationsEnabled ? LT_colsigm - LT_rect + Inflow*FillLevelFlag : 0">
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+            <Formula id="fPauJ0fLpk61w78HrNm4RQ" name="PARAM_LiquidTransferRate_rect" dim="Flow" formula="w*Liquid">
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+            <Formula id="4aipDQ1MVE-V-2yyaX3Q9g" name="PARAM_VolumeGutWall_Rectum" dim="Volume" formula="V_Intestine * 0.055">
+              <Paths>
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+            <Formula id="m5j9Xpv1PUujWY5hWaaS6A" name="PARAM_K_Water_CELL_rect" formula="K_water_cell">
+              <Paths>
+                <Path path="631" as="183" />
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+            <Formula id="6Z73Gk4WbEiv1RkorQZIdw" name="VOLUME_VascularEndo_liv" dim="Volume" formula="SA_pls_int*d_endo">
+              <Paths>
+                <Path path="166" as="167" dim="127" />
+                <Path path="632" as="169" dim="170" />
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+            <Formula id="NeZcEvDV_k2GhukQNLpbeQ" name="PARAM_Allometric scale factor_LiverZone" formula="Liver_Parameter">
+              <Paths>
+                <Path path="633" as="634" />
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+            </Formula>
+            <Formula id="ydre17hfLU2Y1u6A4uOXdg" name="PARAM_Density (tissue)_LiverZone" dim="Density" formula="Liver_Parameter">
+              <Paths>
+                <Path path="635" as="634" dim="133" />
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+            <Formula id="bmActhe4rUCfHNoeEPn1hQ" name="PARAM_Fraction of blood for sampling_LiverZone" formula="Liver_Parameter">
+              <Paths>
+                <Path path="636" as="634" />
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+            </Formula>
+            <Formula id="0uVIwHTGPUqHosZbUkXEDQ" name="PARAM_Volume_Periportal" dim="Volume" formula="V_liv * (IsLiverZonated ? f_periportal : 1)">
+              <Paths>
+                <Path path="637" as="638" dim="24" />
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+            <Formula id="cY_6PA10eUKbEe2AxEgWcw" name="PARAM_Flow fraction via large pores_LiverZone" formula="Liver_Parameter">
+              <Paths>
+                <Path path="643" as="634" />
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+            <Formula id="iShmPT0Zc02yNJRaJoQ2_Q" name="PARAM_Fluid_recirculation_flow_rate_Liver_Periportal" dim="Flow" formula="J_iso * (IsLiverZonated?  f_periportal : 1)">
+              <Paths>
+                <Path path="644" as="645" dim="157" />
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+            <Formula id="zURrstlIAEGi-Ju0VvdVyw" name="PARAM_Hydraulic conductivity_LiverZone" dim="Hydraulic conductivity" formula="Liver_Parameter">
+              <Paths>
+                <Path path="646" as="634" dim="647" />
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+            <Formula id="-0rrymhN3kiBrD_2WTaAUA" name="PARAM_Lymph_flow_rate_Liver_Periportal" dim="Flow" formula="Q_lymph * (IsLiverZonated?  f_periportal : 1)">
+              <Paths>
+                <Path path="648" as="156" dim="157" />
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+            <Formula id="PmzDG-5WrUKeEKUeghSYpA" name="PARAM_Radius (large pores)_LiverZone" dim="Length" formula="Liver_Parameter">
+              <Paths>
+                <Path path="649" as="634" dim="127" />
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+            <Formula id="VNBb2-2WG0CAxCny20P5Ug" name="PARAM_Radius (small pores)_LiverZone" dim="Length" formula="Liver_Parameter">
+              <Paths>
+                <Path path="650" as="634" dim="127" />
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+            <Formula id="Pzpz4blB-0aJaLhbIVrogg" name="VOLUME_VascularEndo_liv_periportal" dim="Volume" formula="SA_pls_int*d_endo">
+              <Paths>
+                <Path path="166" as="167" dim="127" />
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+            <Formula id="w1AxDT0MGE-AoYigSYDnEg" name="PARAM_Vf (lipid)_LiverZone" formula="Liver_Parameter">
+              <Paths>
+                <Path path="652" as="634" />
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+            <Formula id="fKCGKyQp4EaaX2xZG1-ceQ" name="PARAM_Vf (neutral lipid)-PT_LiverZone" formula="Liver_Parameter">
+              <Paths>
+                <Path path="653" as="634" />
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+            <Formula id="X5smbsmZ3EGDbyakvHANHQ" name="PARAM_Vf (phospholipid)-PT_LiverZone" formula="Liver_Parameter">
+              <Paths>
+                <Path path="654" as="634" />
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+            <Formula id="fLHeycB2bEaF4A0Inolp_w" name="PARAM_Vf (protein)_LiverZone" formula="Liver_Parameter">
+              <Paths>
+                <Path path="655" as="634" />
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+            </Formula>
+            <Formula id="aaabYn8N3UeY1uohZvChmA" name="PARAM_Albumin ratio (tissue/plasma)_LiverZone" formula="Liver_Parameter">
+              <Paths>
+                <Path path="656" as="634" />
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+            </Formula>
+            <Formula id="x0d20DoAREqDXee2afnajw" name="PARAM_Albumin ratio (tissue/plasma)-PT_LiverZone" formula="Liver_Parameter">
+              <Paths>
+                <Path path="657" as="634" />
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+            </Formula>
+            <Formula id="pkCiDsaPZ0iMOw-UhqOYPg" name="PARAM_Fraction vascular_LiverZone" formula="Liver_Parameter">
+              <Paths>
+                <Path path="135" as="634" />
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+            </Formula>
+            <Formula id="wQLOzVc_fEq-qzhq7Ni_5w" name="PARAM_Lipoprotein ratio (tissue/plasma)_LiverZone" formula="Liver_Parameter">
+              <Paths>
+                <Path path="658" as="634" />
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+            <Formula id="a5E9vQHGeU2K-aC2SYlYJw" name="PARAM_Microsomal protein mass/g tissue_LiverZone" dim="Mass per tissue" formula="Liver_Parameter">
+              <Paths>
+                <Path path="659" as="634" dim="660" />
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+            </Formula>
+            <Formula id="Ije5FafDSEmFC1TrFSEEfA" name="PARAM_Number of cells/g tissue_LiverZone" dim="Count per mass" formula="Liver_Parameter">
+              <Paths>
+                <Path path="661" as="634" dim="662" />
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+            <Formula id="1aiq4aWndk-jsSgEPTDQkA" name="PARAM_Vf (water)_LiverZone" formula="Liver_Parameter">
+              <Paths>
+                <Path path="663" as="634" />
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+            <Formula id="j8XRW8KFrkGxoTVtyYJqzw" name="PARAM_Vf (water)-PT_LiverZone" formula="Liver_Parameter">
+              <Paths>
+                <Path path="664" as="634" />
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+            <Formula id="nwDLN_ltPECLMJnNdvfljA" name="PARAM_f_cell_LiverZone" formula="Liver_Parameter">
+              <Paths>
+                <Path path="180" as="634" />
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+            <Formula id="eYpiQeKFGEqXYXCKtnk_cA" name="PARAM_Fraction interstitial_LiverZone" formula="Liver_Parameter">
+              <Paths>
+                <Path path="175" as="634" />
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+            <Formula id="YzBUzujmW0WjO9MEoqLikw" name="PARAM_Vf (neutral lipid)-RR_LiverZone" formula="Liver_Parameter">
+              <Paths>
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+            <Formula id="N85nhFuI4UGWkHaBKLaG5w" name="PARAM_Vf (neutral lipid)-WS_LiverZone" formula="Liver_Parameter">
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+                <Path path="666" as="634" />
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+            <Formula id="d2LO3Ks77EiZsadRqIdWLQ" name="PARAM_Vf (extracellular water)-RR_LiverZone" formula="Liver_Parameter">
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+            <Formula id="yle2gjYraEacdW2qiPLbLQ" name="PARAM_Vf (protein)-WS_LiverZone" formula="Liver_Parameter">
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+            <Formula id="G8Cf0Ao8A0Ox1edIqHdong" name="PARAM_Vf (intracellular water)-RR_LiverZone" formula="Liver_Parameter">
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+              <Paths>
+                <Path path="672" as="634" />
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+            <Formula id="ATjLIunwTkm9POavCPbZ3A" name="PARAM_Acidic phospholipids [mg/g] - RR_LiverZone" formula="Liver_Parameter">
+              <Paths>
+                <Path path="673" as="634" />
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+            <Formula id="Yly7irfBSEONRwzpzT5E6Q" name="PARAM_Vf (acidic phospholipids)-WS_LiverZone" formula="Liver_Parameter">
+              <Paths>
+                <Path path="674" as="634" />
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+            <Formula id="DT2JfrOfbk2yefIXFv3R4w" name="PARAM_Specific blood flow rate_LiverZone" dim="Flow per weight organ" formula="Liver_Parameter">
+              <Paths>
+                <Path path="675" as="634" dim="148" />
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+            <Formula id="nwgnUPIRXU2glCSHdwRh1A" name="PARAM_Q_from_Qspec_LiverZone" dim="Flow" formula="Liver_Parameter">
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+            <Formula id="-n4UAAfsu0OlQ6qJgR04VA" name="PARAM_K_Water_INT_liv" formula="K_water_int">
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+                <Path path="677" as="179" />
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+            <Formula id="d7BtMBVNMkGBeGiAma7Ecg" name="PARAM_PH_Cell_LiverZone" formula="pH_cell_Liver">
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+            <Formula id="JfRMN4_lukyIUnFdWY7Qnw" name="PARAM_K_Water_CELL_liv" formula="K_water_cell">
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+            <Formula id="uep8Gnk-5E608GNzy_NVRA" name="PARAM_Volume_Pericentral" dim="Volume" formula="V_liv * (IsLiverZonated ? 1 - f_periportal : 0)">
+              <Paths>
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+              <Paths>
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+            <Formula id="h136HUqmKECLpy0j1kK2hA" name="VOLUME_VascularEndo_liv_pericentral" dim="Volume" formula="SA_pls_int*d_endo">
+              <Paths>
+                <Path path="166" as="167" dim="127" />
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+            <Formula id="F-f4SIUJmE-fliikGaX71Q" name="VOLUME_VascularEndo_lng" dim="Volume" formula="SA_pls_int*d_endo">
+              <Paths>
+                <Path path="166" as="167" dim="127" />
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+            <Formula id="T-vSZ42ckk6doAz7MZWtTw" name="PARAM_K_Water_INT_lng" formula="K_water_int">
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+            <Formula id="E5oG2FbIMUOneOnjGHjBBA" name="PARAM_K_Water_CELL_lng" formula="K_water_cell">
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+                <Path path="712" as="183" />
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+            <Formula id="FbJvejWKQEC2yJU-5mGB1A" name="VOLUME_VascularEndo_mus" dim="Volume" formula="SA_pls_int*d_endo">
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+            <Formula id="8iH2ohDZuku-MD9XUCfFTg" name="PARAM_K_Water_INT_mus" formula="K_water_int">
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+            <Formula id="91h98mLUTU64965588QzOw" name="VOLUME_VascularEndo_pan" dim="Volume" formula="SA_pls_int*d_endo">
+              <Paths>
+                <Path path="166" as="167" dim="127" />
+                <Path path="716" as="169" dim="170" />
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+            <Formula id="htDvOvJ2dk2VaqWAZzXPGw" name="PARAM_K_Water_INT_pan" formula="K_water_int">
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+                <Path path="717" as="179" />
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+            <Formula id="SsufuszvNU6n8KWtbBFULw" name="PARAM_K_Water_CELL_pan" formula="K_water_cell">
+              <Paths>
+                <Path path="718" as="183" />
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+            <Formula id="cc1afdc_6ES4I56l8Ps4Cg" name="PARAM_Q_Lymph_pve" dim="Flow" formula="Q_Lymph_sto + Q_Lymph_sin_incl_Mucosa + Q_Lymph_lin_incl_Mucosa + Q_Lymph_pan + Q_Lymph_spl">
+              <Paths>
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+                <Path path="721" as="722" dim="157" />
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+                <Path path="727" as="728" dim="157" />
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+                <Path path="705" as="706" dim="157" />
+                <Path path="707" as="708" dim="157" />
+                <Path path="709" as="710" dim="157" />
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+            <Formula id="PdPV-J4sGEOi4SLsy0pw0w" name="VOLUME_VascularEndo_skn" dim="Volume" formula="SA_pls_int*d_endo">
+              <Paths>
+                <Path path="166" as="167" dim="127" />
+                <Path path="729" as="169" dim="170" />
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+            <Formula id="DHSuCiFnZEG81_Yw2ZVMmA" name="PARAM_K_Water_INT_skn" formula="K_water_int">
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+                <Path path="730" as="179" />
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+            <Formula id="dOg2ztqdmkqbKiIk-vtXjQ" name="PARAM_K_Water_CELL_skn" formula="K_water_cell">
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+                <Path path="731" as="183" />
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+            <Formula id="bCzb6aG-60GOqnpBmjVKHg" name="VOLUME_VascularEndo_spl" dim="Volume" formula="SA_pls_int*d_endo">
+              <Paths>
+                <Path path="166" as="167" dim="127" />
+                <Path path="732" as="169" dim="170" />
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+            <Formula id="h4WrpkggukqzOagp1j65XQ" name="PARAM_K_Water_INT_spl" formula="K_water_int">
+              <Paths>
+                <Path path="733" as="179" />
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+            <Formula id="Z_J_Z1DtCEKTOu5UKTjnDA" name="PARAM_K_Water_CELL_spl" formula="K_water_cell">
+              <Paths>
+                <Path path="734" as="183" />
+              </Paths>
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+            <Formula id="AQdOk3vYeESnjaGIiK2RSQ" name="VOLUME_Saliva_Organ" dim="Volume" formula="0.006 * BW / 73">
+              <Paths>
+                <Path path="128" as="129" dim="116" />
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+            </Formula>
+            <Formula id="UWxwleFSdECDymhLy2WmBQ" name="VOLUME_slv_slv" dim="Volume" formula="V_slv">
+              <Paths>
+                <Path path="735" as="736" dim="55" />
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+            <Formula id="MBpwdXYbNUiqS3uQZDhduw" name="PARAM_SA_rbc_pls_Blood_Organ" dim="Area" formula="HCT * A_to_V_bc * 0.6 * V">
+              <Paths>
+                <Path path="737" as="138" dim="55" />
+                <Path path="40" as="41" />
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+            <Formula id="xEuPIYqLIk2lKuyHeKmz_w" name="PARAM_SA_int_cell_bon" dim="Area" formula="(V_bon * 1000 / 28.2)^0.75 * 10 * 1E2">
+              <Paths>
+                <Path path="737" as="740" dim="55" />
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+            <Formula id="pn4TOZacr0GWHd9xAwFj8g" name="PARAM_P_int_cell" dim="Velocity" formula="P * P_int_cell_factor">
+              <Paths>
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+                <Path path="14" as="15" dim="2" />
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+            <Formula id="QkTJVxVP3Ee97Zuh3Lg62w" name="PARAM_P_cell_int" dim="Velocity" formula="P * P_cell_int_factor">
+              <Paths>
+                <Path path="743" as="744" />
+                <Path path="14" as="15" dim="2" />
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+            <Formula id="SZrmcd1JDEW6MIjlHsCCew" name="PARAM_PA_int_cell" dim="Flow" formula="P_int_cell * SA">
+              <Paths>
+                <Path path="745" as="746" dim="2" />
+                <Path path="747" as="748" dim="170" />
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+            <Formula id="y659fcMlZEKHrLpFwmHmIw" name="PARAM_PA_cell_int" dim="Flow" formula="P_cell_int * SA">
+              <Paths>
+                <Path path="749" as="750" dim="2" />
+                <Path path="747" as="748" dim="170" />
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+            <Formula id="AGiWTt8CvEmeuesoKmPNgw" name="PARAM_K_wat_cell" formula="fu/K_cell_pls">
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+            <Formula id="xH6OXEC65ESnPJ2unASWQA" name="PARAM_SA_rbc_pls" dim="Area" formula="HCT * A_to_V_bc * 0.6 * V * f_vas">
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+            <Formula id="YX57qmODbU-M9-4csS_AyA" name="PARAM_SA_pls_int" dim="Area" formula="k * f_vas_org * V_org">
+              <Paths>
+                <Path path="753" as="754" />
+                <Path path="737" as="174" dim="55" />
+                <Path path="755" as="325" dim="366" />
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+            <BlackBoxFormula id="iKUspopJzEClLaOxGRLgvw" name="INTERSTITIAL PARTITION COEFFICIENT FORMULA" />
+            <Formula id="yXJJyWUUEUOJSSViPlaHNw" name="PARAM_SA_int_cell_brn" dim="Area" formula="(V_brn  * 1000 / 1.671)^0.75 * 0.0006 * 1E2">
+              <Paths>
+                <Path path="737" as="756" dim="55" />
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+                <Path path="880" as="880" />
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+            </DiscreteDistributionFormula>
+            <DiscreteDistributionFormula id="MiSGm5xytk-6RE4gu6-krg">
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+            </DiscreteDistributionFormula>
+            <DiscreteDistributionFormula id="kS3acwwBak--bQmoL3MyGQ">
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+              </Paths>
+            </DiscreteDistributionFormula>
+            <NormalDistributionFormula id="7QEqCm4Chkm11cnAsL46eQ" dim="Volume">
+              <Paths>
+                <Path path="880" as="880" dim="55" />
+                <Path path="881" as="881" dim="55" />
+              </Paths>
+            </NormalDistributionFormula>
+            <NormalDistributionFormula id="_jZzJFgPqEWM-QpMz8APFg" dim="Flow per weight organ">
+              <Paths>
+                <Path path="880" as="880" dim="148" />
+                <Path path="881" as="881" dim="148" />
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+            </NormalDistributionFormula>
+            <LogNormalDistributionFormula id="mMLfpB1NQk2HwTbZx3GTCw" dim="Time">
+              <Paths>
+                <Path path="880" as="880" dim="143" />
+                <Path path="882" as="882" />
+              </Paths>
+            </LogNormalDistributionFormula>
+            <NormalDistributionFormula id="8HNCftVpWkeqJMKkpM_Bgw" dim="Volume">
+              <Paths>
+                <Path path="880" as="880" dim="55" />
+                <Path path="881" as="881" dim="55" />
+              </Paths>
+            </NormalDistributionFormula>
+            <NormalDistributionFormula id="pIHP0dbEMU-V6nodk84xvQ" dim="Flow per weight organ">
+              <Paths>
+                <Path path="880" as="880" dim="148" />
+                <Path path="881" as="881" dim="148" />
+              </Paths>
+            </NormalDistributionFormula>
+            <DiscreteDistributionFormula id="vNJCm4SbBkebKERzj3Gd5w" dim="Time">
+              <Paths>
+                <Path path="880" as="880" dim="143" />
+              </Paths>
+            </DiscreteDistributionFormula>
+            <NormalDistributionFormula id="Xq-S3lJ72UaFehdSd3KUDg" dim="Volume">
+              <Paths>
+                <Path path="880" as="880" dim="55" />
+                <Path path="881" as="881" dim="55" />
+              </Paths>
+            </NormalDistributionFormula>
+            <NormalDistributionFormula id="vMvs8ko2p0iw1VddIHjIEQ" dim="Flow per weight organ">
+              <Paths>
+                <Path path="880" as="880" dim="148" />
+                <Path path="881" as="881" dim="148" />
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+            </NormalDistributionFormula>
+            <NormalDistributionFormula id="SN1fiYDhMkqWgo_n_gnxqQ" dim="Volume">
+              <Paths>
+                <Path path="880" as="880" dim="55" />
+                <Path path="881" as="881" dim="55" />
+              </Paths>
+            </NormalDistributionFormula>
+            <NormalDistributionFormula id="Y5BBWkGV4ESjXGe2nFdVpQ" dim="Flow per weight organ">
+              <Paths>
+                <Path path="880" as="880" dim="148" />
+                <Path path="881" as="881" dim="148" />
+              </Paths>
+            </NormalDistributionFormula>
+            <LogNormalDistributionFormula id="28FNKG5n0Ea1yegcWETbwQ" dim="Volume">
+              <Paths>
+                <Path path="880" as="880" dim="55" />
+                <Path path="882" as="882" />
+              </Paths>
+            </LogNormalDistributionFormula>
+            <DiscreteDistributionFormula id="HA3jP5ydYE6Pj8f48SF7hA">
+              <Paths>
+                <Path path="880" as="880" />
+              </Paths>
+            </DiscreteDistributionFormula>
+            <LogNormalDistributionFormula id="EAYQZfzQ0ES0xosS-l99iw" dim="Volume">
+              <Paths>
+                <Path path="880" as="880" dim="55" />
+                <Path path="882" as="882" />
+              </Paths>
+            </LogNormalDistributionFormula>
+            <DiscreteDistributionFormula id="ahXH0foKmEKRndPODOT1UA">
+              <Paths>
+                <Path path="880" as="880" />
+              </Paths>
+            </DiscreteDistributionFormula>
+            <DiscreteDistributionFormula id="CmJjuPqeT0i4qA0yYn43Og">
+              <Paths>
+                <Path path="880" as="880" />
+              </Paths>
+            </DiscreteDistributionFormula>
+            <DiscreteDistributionFormula id="4uDP7veqVEWP0iNzpl-Imw">
+              <Paths>
+                <Path path="880" as="880" />
+              </Paths>
+            </DiscreteDistributionFormula>
+            <DiscreteDistributionFormula id="NAZ-NkT0yUuAQj-0tpPNDg">
+              <Paths>
+                <Path path="880" as="880" />
+              </Paths>
+            </DiscreteDistributionFormula>
+            <DiscreteDistributionFormula id="urI5s6gUR0qCCh_3tM--8Q">
+              <Paths>
+                <Path path="880" as="880" />
+              </Paths>
+            </DiscreteDistributionFormula>
+            <DiscreteDistributionFormula id="hdlXyaxCFEOsx2S7M0WySw">
+              <Paths>
+                <Path path="880" as="880" />
+              </Paths>
+            </DiscreteDistributionFormula>
+            <DiscreteDistributionFormula id="NgZvfGluTEq6K2N-eMZ0JQ">
+              <Paths>
+                <Path path="880" as="880" />
+              </Paths>
+            </DiscreteDistributionFormula>
+            <DiscreteDistributionFormula id="VkPaOl52O0yFPRJPpLIYnw">
+              <Paths>
+                <Path path="880" as="880" />
+              </Paths>
+            </DiscreteDistributionFormula>
+            <DiscreteDistributionFormula id="L-MQti_D4UOmbG6I14hpQA">
+              <Paths>
+                <Path path="880" as="880" />
+              </Paths>
+            </DiscreteDistributionFormula>
+            <DiscreteDistributionFormula id="WJpz5pl8P0uJZHZHPRgNsg">
+              <Paths>
+                <Path path="880" as="880" />
+              </Paths>
+            </DiscreteDistributionFormula>
+            <DiscreteDistributionFormula id="ZJ98mvWsW0iyXWtpG94t9w">
+              <Paths>
+                <Path path="880" as="880" />
+              </Paths>
+            </DiscreteDistributionFormula>
+            <DiscreteDistributionFormula id="QxqHwXvV1kKszbxmFu5Usg">
+              <Paths>
+                <Path path="880" as="880" />
+              </Paths>
+            </DiscreteDistributionFormula>
+            <DiscreteDistributionFormula id="KjVjbpAwDEuOM3u3zOc62w">
+              <Paths>
+                <Path path="880" as="880" />
+              </Paths>
+            </DiscreteDistributionFormula>
+            <DiscreteDistributionFormula id="zWK5nvueBE-Ic15ysfqYhw">
+              <Paths>
+                <Path path="880" as="880" />
+              </Paths>
+            </DiscreteDistributionFormula>
+            <DiscreteDistributionFormula id="GlxuimVsPEeic2NHGYWraQ">
+              <Paths>
+                <Path path="880" as="880" />
+              </Paths>
+            </DiscreteDistributionFormula>
+            <NormalDistributionFormula id="X22nwMziLk-0qpVRNyytCw" dim="Flow per weight organ">
+              <Paths>
+                <Path path="880" as="880" dim="148" />
+                <Path path="881" as="881" dim="148" />
+              </Paths>
+            </NormalDistributionFormula>
+            <NormalDistributionFormula id="scEHTBKHvkGAocCvOJlnvg" dim="Volume">
+              <Paths>
+                <Path path="880" as="880" dim="55" />
+                <Path path="881" as="881" dim="55" />
+              </Paths>
+            </NormalDistributionFormula>
+            <NormalDistributionFormula id="QeU1hwJTMU-E_vONpE8Shg" dim="Flow per weight organ">
+              <Paths>
+                <Path path="880" as="880" dim="148" />
+                <Path path="881" as="881" dim="148" />
+              </Paths>
+            </NormalDistributionFormula>
+            <NormalDistributionFormula id="JopsieBhlUq5XPXDLtl-DQ" dim="Volume">
+              <Paths>
+                <Path path="880" as="880" dim="55" />
+                <Path path="881" as="881" dim="55" />
+              </Paths>
+            </NormalDistributionFormula>
+            <NormalDistributionFormula id="cU9BredOgkS4ZNs-zR7kRw" dim="Volume">
+              <Paths>
+                <Path path="880" as="880" dim="55" />
+                <Path path="881" as="881" dim="55" />
+              </Paths>
+            </NormalDistributionFormula>
+            <NormalDistributionFormula id="akLOqlQgdEGdqBSqFq5LgA" dim="Flow per weight organ">
+              <Paths>
+                <Path path="880" as="880" dim="148" />
+                <Path path="881" as="881" dim="148" />
+              </Paths>
+            </NormalDistributionFormula>
+            <LogNormalDistributionFormula id="6GjQ02Gt_UGMWTemBcFx-Q" dim="Volume">
+              <Paths>
+                <Path path="880" as="880" dim="55" />
+                <Path path="882" as="882" />
+              </Paths>
+            </LogNormalDistributionFormula>
+            <NormalDistributionFormula id="8WtHppqfAEif16gryyDaZA" dim="Flow per weight organ">
+              <Paths>
+                <Path path="880" as="880" dim="148" />
+                <Path path="881" as="881" dim="148" />
+              </Paths>
+            </NormalDistributionFormula>
+          </Formulas>
+          <StringMap>
+            <Map s="MOLECULE|Calculated specific intestinal permeability (transcellular)" id="0" />
+            <Map s="P_int_InVitro" id="1" />
+            <Map s="Velocity" id="2" />
+            <Map s="MOLECULE|Parameter b for correlation of intestinal permeability (transcellular)" id="3" />
+            <Map s="b" id="4" />
+            <Map s="MOLECULE|Parameter m for correlation of intestinal permeability (transcellular)" id="5" />
+            <Map s="m" id="6" />
+            <Map s="MOLECULE|Specific intestinal permeability (transcellular)" id="7" />
+            <Map s="..|Default Intestinal permeability (transcellular)" id="8" />
+            <Map s="P_int_trans_default" id="9" />
+            <Map s="..|Intestinal permeability (transcellular)" id="10" />
+            <Map s="P_int_trans" id="11" />
+            <Map s="MOLECULE|P_bc_pls_factor" id="12" />
+            <Map s="P_rbc_pls_factor" id="13" />
+            <Map s="MOLECULE|Permeability" id="14" />
+            <Map s="P" id="15" />
+            <Map s="MOLECULE|P_pls_bc_factor" id="16" />
+            <Map s="P_pls_rbc_factor" id="17" />
+            <Map s="..|BP_AGP" id="18" />
+            <Map s="Agp" id="19" />
+            <Map s="..|BP_ALBUMIN" id="20" />
+            <Map s="Albumin" id="21" />
+            <Map s="..|Fraction unbound (plasma, reference value)" id="22" />
+            <Map s="fu_ref" id="23" />
+            <Map s="Fraction" id="24" />
+            <Map s="..|Plasma protein binding partner" id="25" />
+            <Map s="BindingPartner" id="26" />
+            <Map s="Organism|Ontogeny factor (albumin)" id="27" />
+            <Map s="AlbuminOntgenyFactor" id="28" />
+            <Map s="Organism|Ontogeny factor (alpha1-acid glycoprotein)" id="29" />
+            <Map s="AgpOntogenyFactor" id="30" />
+            <Map s="Organism|Plasma protein scale factor" id="31" />
+            <Map s="PlasmaProteinScaleFactor" id="32" />
+            <Map s="MOLECULE|Fraction unbound (plasma)" id="33" />
+            <Map s="fu" id="34" />
+            <Map s="MOLECULE|Lipophilicity" id="35" />
+            <Map s="LogP" id="36" />
+            <Map s="Log Units" id="37" />
+            <Map s="MOLECULE|Partition coefficient (water/protein)" id="38" />
+            <Map s="KProt" id="39" />
+            <Map s="Organism|Hematocrit" id="40" />
+            <Map s="HCT" id="41" />
+            <Map s="Organism|Vf (lipid, blood cells)" id="42" />
+            <Map s="f_lipids_rbc" id="43" />
+            <Map s="Organism|Vf (protein,blood cells)" id="44" />
+            <Map s="f_proteins_rbc" id="45" />
+            <Map s="Organism|Vf (water,blood cells)" id="46" />
+            <Map s="f_water_rbc" id="47" />
+            <Map s="Organism|Rate constant for endosomal uptake (global)" id="48" />
+            <Map s="K_uptake" id="49" />
+            <Map s="Inversed time" id="50" />
+            <Map s="Organism|Rate constant for recycling from endosomal space (global)" id="51" />
+            <Map s="K_rec" id="52" />
+            <Map s="Organism|ArterialBlood|Plasma|Volume" id="53" />
+            <Map s="V_pls_art" id="54" />
+            <Map s="Volume" id="55" />
+            <Map s="Organism|Bone|Plasma|Volume" id="56" />
+            <Map s="V_pls_bon" id="57" />
+            <Map s="Organism|Brain|Plasma|Volume" id="58" />
+            <Map s="V_pls_brn" id="59" />
+            <Map s="Organism|Fat|Plasma|Volume" id="60" />
+            <Map s="V_pls_fat" id="61" />
+            <Map s="Organism|Gonads|Plasma|Volume" id="62" />
+            <Map s="V_pls_tes" id="63" />
+            <Map s="Organism|Heart|Plasma|Volume" id="64" />
+            <Map s="V_pls_hrt" id="65" />
+            <Map s="Organism|Kidney|Plasma|Volume" id="66" />
+            <Map s="V_pls_kid" id="67" />
+            <Map s="Organism|LargeIntestine|Plasma|Volume" id="68" />
+            <Map s="V_pls_lin" id="69" />
+            <Map s="Organism|Lung|Plasma|Volume" id="70" />
+            <Map s="V_pls_lng" id="71" />
+            <Map s="Organism|Muscle|Plasma|Volume" id="72" />
+            <Map s="V_pls_mus" id="73" />
+            <Map s="Organism|Pancreas|Plasma|Volume" id="74" />
+            <Map s="V_pls_pan" id="75" />
+            <Map s="Organism|PortalVein|Plasma|Volume" id="76" />
+            <Map s="V_pls_pve" id="77" />
+            <Map s="Organism|Skin|Plasma|Volume" id="78" />
+            <Map s="V_pls_skn" id="79" />
+            <Map s="Organism|SmallIntestine|Plasma|Volume" id="80" />
+            <Map s="V_pls_sin" id="81" />
+            <Map s="Organism|Spleen|Plasma|Volume" id="82" />
+            <Map s="V_pls_spl" id="83" />
+            <Map s="Organism|Stomach|Plasma|Volume" id="84" />
+            <Map s="V_pls_sto" id="85" />
+            <Map s="Organism|VenousBlood|Plasma|Volume" id="86" />
+            <Map s="V_pls_ven" id="87" />
+            <Map s="Organism|SmallIntestine|Mucosa|Duodenum|Plasma|Volume" id="88" />
+            <Map s="V_pls_duo" id="89" />
+            <Map s="Organism|SmallIntestine|Mucosa|UpperJejunum|Plasma|Volume" id="90" />
+            <Map s="V_pls_uje" id="91" />
+            <Map s="Organism|SmallIntestine|Mucosa|LowerJejunum|Plasma|Volume" id="92" />
+            <Map s="V_pls_lje" id="93" />
+            <Map s="Organism|SmallIntestine|Mucosa|UpperIleum|Plasma|Volume" id="94" />
+            <Map s="V_pls_uil" id="95" />
+            <Map s="Organism|SmallIntestine|Mucosa|LowerIleum|Plasma|Volume" id="96" />
+            <Map s="V_pls_lil" id="97" />
+            <Map s="Organism|LargeIntestine|Mucosa|Caecum|Plasma|Volume" id="98" />
+            <Map s="V_pls_cae" id="99" />
+            <Map s="Organism|LargeIntestine|Mucosa|ColonAscendens|Plasma|Volume" id="100" />
+            <Map s="V_pls_colasc" id="101" />
+            <Map s="Organism|LargeIntestine|Mucosa|ColonTransversum|Plasma|Volume" id="102" />
+            <Map s="V_pls_coltrans" id="103" />
+            <Map s="Organism|LargeIntestine|Mucosa|ColonDescendens|Plasma|Volume" id="104" />
+            <Map s="V_pls_coldesc" id="105" />
+            <Map s="Organism|LargeIntestine|Mucosa|ColonSigmoid|Plasma|Volume" id="106" />
+            <Map s="V_pls_colsigm" id="107" />
+            <Map s="Organism|LargeIntestine|Mucosa|Rectum|Plasma|Volume" id="108" />
+            <Map s="V_pls_rect" id="109" />
+            <Map s="Organism|Liver|Periportal|Plasma|Volume" id="110" />
+            <Map s="V_pls_prp" id="111" />
+            <Map s="Organism|Liver|Pericentral|Plasma|Volume" id="112" />
+            <Map s="V_pls_prc" id="113" />
+            <Map s="Organism|Weight of blood organs" id="114" />
+            <Map s="Weight_blood" id="115" />
+            <Map s="Mass" id="116" />
+            <Map s="Organism|Weight of tissue organs" id="117" />
+            <Map s="Weight_tissue" id="118" />
+            <Map s="..|Age" id="119" />
+            <Map s="Age" id="120" />
+            <Map s="Age in years" id="121" />
+            <Map s="..|Gestational age" id="122" />
+            <Map s="GA" id="123" />
+            <Map s="Age in weeks" id="124" />
+            <Map s="Organism|Height" id="125" />
+            <Map s="Height" id="126" />
+            <Map s="Length" id="127" />
+            <Map s="Organism|Weight" id="128" />
+            <Map s="BW" id="129" />
+            <Map s="H" id="130" />
+            <Map s="W" id="131" />
+            <Map s="..|Density (tissue)" id="132" />
+            <Map s="Density" id="133" />
+            <Map s="..|Volume" id="134" />
+            <Map s="..|..|Fraction vascular" id="135" />
+            <Map s="f_vas" id="136" />
+            <Map s="..|..|Volume" id="137" />
+            <Map s="V" id="138" />
+            <Map s="MOLECULE|Ontogeny factor" id="139" />
+            <Map s="f_onto" id="140" />
+            <Map s="MOLECULE|t1/2 (liver)" id="141" />
+            <Map s="tHalf" id="142" />
+            <Map s="Time" id="143" />
+            <Map s="MOLECULE|Partition coefficient (blood cells/plasma)" id="144" />
+            <Map s="K_rbc" id="145" />
+            <Map s="..|Specific blood flow rate" id="146" />
+            <Map s="Qspec" id="147" />
+            <Map s="Flow per weight organ" id="148" />
+            <Map s="..|Weight (tissue)" id="149" />
+            <Map s="Weight" id="150" />
+            <Map s="..|Flow fraction via large pores" id="151" />
+            <Map s="alpha_l" id="152" />
+            <Map s="..|Fluid recirculation flow proportionality factor" id="153" />
+            <Map s="f_Jiso" id="154" />
+            <Map s="..|Lymph flow rate" id="155" />
+            <Map s="Q_lymph" id="156" />
+            <Map s="Flow" id="157" />
+            <Map s="..|Organ volume mouse" id="158" />
+            <Map s="V_mouse" id="159" />
+            <Map s="Organism|Scaling exponent for fluid recirculation flow rate" id="160" />
+            <Map s="exp_Jiso_scale" id="161" />
+            <Map s="..|Blood flow rate" id="162" />
+            <Map s="Q" id="163" />
+            <Map s="..|Lymph flow proportionality factor" id="164" />
+            <Map s="f_lymph" id="165" />
+            <Map s="Organism|Thickness (endothelium)" id="166" />
+            <Map s="d_endo" id="167" />
+            <Map s="Neighborhoods|Bone_pls_Bone_int|Surface area (plasma/interstitial)" id="168" />
+            <Map s="SA_pls_int" id="169" />
+            <Map s="Area" id="170" />
+            <Map s="..|Fraction interstitial" id="171" />
+            <Map s="f_int" id="172" />
+            <Map s="..|Fraction vascular" id="173" />
+            <Map s="V_org" id="174" />
+            <Map s="..|..|Fraction interstitial" id="175" />
+            <Map s="Organism|pH (interstitial)" id="176" />
+            <Map s="pH_int" id="177" />
+            <Map s="Neighborhoods|Bone_int_Bone_cell|MOLECULE|Partition coefficient (interstitial/water)" id="178" />
+            <Map s="K_water_int" id="179" />
+            <Map s="..|..|Fraction intracellular" id="180" />
+            <Map s="f_cell" id="181" />
+            <Map s="Neighborhoods|Bone_int_Bone_cell|MOLECULE|Partition coefficient (intracellular/water)" id="182" />
+            <Map s="K_water_cell" id="183" />
+            <Map s="..|Gallbladder ejection half-time" id="184" />
+            <Map s="EHC_HalfTime" id="185" />
+            <Map s="Neighborhoods|Brain_pls_Brain_int|Surface area (plasma/interstitial)" id="186" />
+            <Map s="Neighborhoods|Brain_int_Brain_cell|MOLECULE|Partition coefficient (interstitial/water)" id="187" />
+            <Map s="Neighborhoods|Brain_int_Brain_cell|MOLECULE|Partition coefficient (intracellular/water)" id="188" />
+            <Map s="Neighborhoods|Fat_pls_Fat_int|Surface area (plasma/interstitial)" id="189" />
+            <Map s="Neighborhoods|Fat_int_Fat_cell|MOLECULE|Partition coefficient (interstitial/water)" id="190" />
+            <Map s="Neighborhoods|Fat_int_Fat_cell|MOLECULE|Partition coefficient (intracellular/water)" id="191" />
+            <Map s="Neighborhoods|Gonads_pls_Gonads_int|Surface area (plasma/interstitial)" id="192" />
+            <Map s="Neighborhoods|Gonads_int_Gonads_cell|MOLECULE|Partition coefficient (interstitial/water)" id="193" />
+            <Map s="Neighborhoods|Gonads_int_Gonads_cell|MOLECULE|Partition coefficient (intracellular/water)" id="194" />
+            <Map s="Neighborhoods|Heart_pls_Heart_int|Surface area (plasma/interstitial)" id="195" />
+            <Map s="Neighborhoods|Heart_int_Heart_cell|MOLECULE|Partition coefficient (interstitial/water)" id="196" />
+            <Map s="Neighborhoods|Heart_int_Heart_cell|MOLECULE|Partition coefficient (intracellular/water)" id="197" />
+            <Map s="Neighborhoods|Kidney_pls_Kidney_int|Surface area (plasma/interstitial)" id="198" />
+            <Map s="Organism|Kidney|GFR (specific)" id="199" />
+            <Map s="GFRspec" id="200" />
+            <Map s="Organism|Kidney|Weight (tissue)" id="201" />
+            <Map s="Weight_Kidney" id="202" />
+            <Map s="Organism|Estimated gestational age" id="203" />
+            <Map s="PMA" id="204" />
+            <Map s="Organism|Kidney|GFRmat" id="205" />
+            <Map s="GFR_mat" id="206" />
+            <Map s="Organism|Kidney|Hill coefficient for GFR" id="207" />
+            <Map s="Hill" id="208" />
+            <Map s="Organism|Kidney|Renal aging scaling factor" id="209" />
+            <Map s="Renal_aging_scaling_factor" id="210" />
+            <Map s="Organism|Kidney|TM50 for GFR" id="211" />
+            <Map s="TM50" id="212" />
+            <Map s="Organism|Kidney|Volume (standard kidney)" id="213" />
+            <Map s="V_kid_std" id="214" />
+            <Map s="Organism|Kidney|fGFRpremat" id="215" />
+            <Map s="GFR_premat" id="216" />
+            <Map s="Organism|Age" id="217" />
+            <Map s="Organism|Kidney|Age of aging onset" id="218" />
+            <Map s="Age_onset" id="219" />
+            <Map s="Organism|Kidney|Aging half-time" id="220" />
+            <Map s="TA50" id="221" />
+            <Map s="Organism|Kidney|Hill coefficient for aging GFR" id="222" />
+            <Map s="Organism|Kidney|Maximal decreasing rate factor" id="223" />
+            <Map s="Decrease_Factor" id="224" />
+            <Map s="Neighborhoods|Kidney_int_Kidney_cell|MOLECULE|Partition coefficient (interstitial/water)" id="225" />
+            <Map s="Neighborhoods|Kidney_int_Kidney_cell|MOLECULE|Partition coefficient (intracellular/water)" id="226" />
+            <Map s="..|Fraction of geometric volume filled with liquid" id="227" />
+            <Map s="FillLevel" id="228" />
+            <Map s="..|Liquid" id="229" />
+            <Map s="Liquid" id="230" />
+            <Map s="..|Distal radius" id="231" />
+            <Map s="r2" id="232" />
+            <Map s="..|Length" id="233" />
+            <Map s="L" id="234" />
+            <Map s="..|Proximal radius" id="235" />
+            <Map s="r1" id="236" />
+            <Map s="..|Gastric emptying time" id="237" />
+            <Map s="GET" id="238" />
+            <Map s="..|Fractional steady state fill level" id="239" />
+            <Map s="SteadyStateFillLevel" id="240" />
+            <Map s="..|FillLevelFlag" id="241" />
+            <Map s="FillLevelFlag" id="242" />
+            <Map s="..|Liquid transfer rate" id="243" />
+            <Map s="LT_sto" id="244" />
+            <Map s="..|Secretion of liquid" id="245" />
+            <Map s="Inflow" id="246" />
+            <Map s="..|..|OralApplicationsEnabled" id="247" />
+            <Map s="OralApplicationsEnabled" id="248" />
+            <Map s="..|Intestinal transit rate (absolute)" id="249" />
+            <Map s="w" id="250" />
+            <Map s="..|..|Duodenum|FillLevelFlag" id="251" />
+            <Map s="FillLevelFlagNext" id="252" />
+            <Map s="..|pH in fasted state" id="253" />
+            <Map s="pH_fasted" id="254" />
+            <Map s="..|Inverse rate of inflow of liquid into stomach" id="255" />
+            <Map s="StomachInflowTime" id="256" />
+            <Map s="..|Geometric surface area" id="257" />
+            <Map s="..|Thickness of gut wall" id="258" />
+            <Map s="d" id="259" />
+            <Map s="MOLECULE|Ontogeny factor GI" id="260" />
+            <Map s="MOLECULE|CT_NEUTRAL" id="261" />
+            <Map s="CT_NEUTRAL" id="262" />
+            <Map s="MOLECULE|Compound type 0" id="263" />
+            <Map s="CT0" id="264" />
+            <Map s="MOLECULE|pKa value 0" id="265" />
+            <Map s="pKa_0" id="266" />
+            <Map s="..|..|pH" id="267" />
+            <Map s="pH" id="268" />
+            <Map s="MOLECULE|Compound type 1" id="269" />
+            <Map s="CT1" id="270" />
+            <Map s="MOLECULE|pKa value 1" id="271" />
+            <Map s="pKa_1" id="272" />
+            <Map s="MOLECULE|Compound type 2" id="273" />
+            <Map s="CT2" id="274" />
+            <Map s="MOLECULE|pKa value 2" id="275" />
+            <Map s="pKa_2" id="276" />
+            <Map s="..|pKa_pH_WS_lum_F1" id="277" />
+            <Map s="F1" id="278" />
+            <Map s="..|pKa_pH_WS_lum_F2" id="279" />
+            <Map s="F2" id="280" />
+            <Map s="..|pKa_pH_WS_lum_F3" id="281" />
+            <Map s="F3" id="282" />
+            <Map s="..|Solubility table" id="283" />
+            <Map s="SolubilityTable" id="284" />
+            <Map s="Concentration (mass)" id="285" />
+            <Map s="..|Solubility_pKa_pH_Factor" id="286" />
+            <Map s="Solubility_pKa_pH_Factor" id="287" />
+            <Map s="MOLECULE|Solubility at reference pH" id="288" />
+            <Map s="Solubility" id="289" />
+            <Map s="MOLECULE|Solubility_pKa_pH_Factor" id="290" />
+            <Map s="Solubility_pKa_REFpH_Factor" id="291" />
+            <Map s="MOLECULE|Solubility table" id="292" />
+            <Map s="Table" id="293" />
+            <Map s="XArg" id="294" />
+            <Map s="..|pKa_pH_WS_lum_K1" id="295" />
+            <Map s="K1" id="296" />
+            <Map s="..|pKa_pH_WS_lum_K2" id="297" />
+            <Map s="K2" id="298" />
+            <Map s="..|pKa_pH_WS_lum_K3" id="299" />
+            <Map s="K3" id="300" />
+            <Map s="..|pKa_pH_WS_lum_K4" id="301" />
+            <Map s="K4" id="302" />
+            <Map s="..|pKa_pH_WS_lum_K5" id="303" />
+            <Map s="K5" id="304" />
+            <Map s="..|pKa_pH_WS_lum_K6" id="305" />
+            <Map s="K6" id="306" />
+            <Map s="..|pKa_pH_WS_lum_K7" id="307" />
+            <Map s="K7" id="308" />
+            <Map s="..|pKa_pH_WS_lum_K8" id="309" />
+            <Map s="K8" id="310" />
+            <Map s="MOLECULE|Solubility gain per charge" id="311" />
+            <Map s="base" id="312" />
+            <Map s="MOLECULE|t1/2 (intestine)" id="313" />
+            <Map s=".." id="314" />
+            <Map s="M" id="315" />
+            <Map s="Amount" id="316" />
+            <Map s="..|Solubility" id="317" />
+            <Map s="MOLECULE|Enable supersaturation" id="318" />
+            <Map s="EnableSupersaturarion" id="319" />
+            <Map s="MOLECULE|Molecular weight" id="320" />
+            <Map s="MW" id="321" />
+            <Map s="Molecular weight" id="322" />
+            <Map s="..|..|Liquid" id="323" />
+            <Map s="alpha" id="324" />
+            <Map s="k" id="325" />
+            <Map s="inflow" id="326" />
+            <Map s="..|..|Stomach|Fractional steady state fill level" id="327" />
+            <Map s="alpha_p" id="328" />
+            <Map s="..|..|Stomach|Intestinal transit rate (absolute)" id="329" />
+            <Map s="k_p" id="330" />
+            <Map s="..|..|Stomach|Volume" id="331" />
+            <Map s="V_p" id="332" />
+            <Map s="..|..|..|Height" id="333" />
+            <Map s="..|r2_p0" id="334" />
+            <Map s="r2_p0" id="335" />
+            <Map s="..|r2_p1" id="336" />
+            <Map s="r2_p1" id="337" />
+            <Map s="..|Effective surface area enhancement factor" id="338" />
+            <Map s="AeffFactor" id="339" />
+            <Map s="Ageom" id="340" />
+            <Map s="Organism|Lumen|Effective surface area variability factor" id="341" />
+            <Map s="AeffVariabilityFactor" id="342" />
+            <Map s="..|Intestinal transit rate" id="343" />
+            <Map s="LuminalVelocity" id="344" />
+            <Map s="Organism|SmallIntestine|Small intestinal transit time factor" id="345" />
+            <Map s="SITT_fact" id="346" />
+            <Map s="..|L_p0" id="347" />
+            <Map s="L_p0" id="348" />
+            <Map s="..|L_p1" id="349" />
+            <Map s="L_p1" id="350" />
+            <Map s="..|Absorption of liquid" id="351" />
+            <Map s="Outflow" id="352" />
+            <Map s="LT_duo" id="353" />
+            <Map s="..|..|Stomach|Liquid transfer rate" id="354" />
+            <Map s="..|..|UpperJejunum|FillLevelFlag" id="355" />
+            <Map s="..|r1_p0" id="356" />
+            <Map s="r1_p0" id="357" />
+            <Map s="..|r1_p1" id="358" />
+            <Map s="r1_p1" id="359" />
+            <Map s="..|Thickness_p1" id="360" />
+            <Map s="Thickness_p1" id="361" />
+            <Map s="..|Thickness_p2" id="362" />
+            <Map s="Thickness_p2" id="363" />
+            <Map s="..|Thickness_p3" id="364" />
+            <Map s="Thickness_p3" id="365" />
+            <Map s="Inversed length" id="366" />
+            <Map s="Organism|SmallIntestine|Volume" id="367" />
+            <Map s="V_Intestine" id="368" />
+            <Map s="Neighborhoods|Lumen_duo_Duodenum_pls|MOLECULE|Sum of active process rates" id="369" />
+            <Map s="ActiveRates_para" id="370" />
+            <Map s="Amount per time" id="371" />
+            <Map s="Neighborhoods|Lumen_duo_Duodenum_cell|MOLECULE|Sum of active process rates" id="372" />
+            <Map s="ActiveRates_trans" id="373" />
+            <Map s="Neighborhoods|Lumen_duo_Duodenum_pls|MOLECULE|Sum of passive process rates" id="374" />
+            <Map s="PassiveRates_para" id="375" />
+            <Map s="Neighborhoods|Lumen_duo_Duodenum_cell|MOLECULE|Sum of passive process rates" id="376" />
+            <Map s="PassiveRates_trans" id="377" />
+            <Map s="..|..|Duodenum|Fractional steady state fill level" id="378" />
+            <Map s="..|..|Duodenum|Intestinal transit rate (absolute)" id="379" />
+            <Map s="..|..|Duodenum|Volume" id="380" />
+            <Map s="LT_uje" id="381" />
+            <Map s="..|..|Duodenum|Liquid transfer rate" id="382" />
+            <Map s="..|..|LowerJejunum|FillLevelFlag" id="383" />
+            <Map s="Neighborhoods|Lumen_uje_UpperJejunum_pls|MOLECULE|Sum of active process rates" id="384" />
+            <Map s="Neighborhoods|Lumen_uje_UpperJejunum_cell|MOLECULE|Sum of active process rates" id="385" />
+            <Map s="Neighborhoods|Lumen_uje_UpperJejunum_pls|MOLECULE|Sum of passive process rates" id="386" />
+            <Map s="Neighborhoods|Lumen_uje_UpperJejunum_cell|MOLECULE|Sum of passive process rates" id="387" />
+            <Map s="..|..|UpperJejunum|Fractional steady state fill level" id="388" />
+            <Map s="..|..|UpperJejunum|Intestinal transit rate (absolute)" id="389" />
+            <Map s="..|..|UpperJejunum|Volume" id="390" />
+            <Map s="LT_lje" id="391" />
+            <Map s="..|..|UpperJejunum|Liquid transfer rate" id="392" />
+            <Map s="..|..|UpperIleum|FillLevelFlag" id="393" />
+            <Map s="Neighborhoods|Lumen_lje_LowerJejunum_pls|MOLECULE|Sum of active process rates" id="394" />
+            <Map s="Neighborhoods|Lumen_lje_LowerJejunum_cell|MOLECULE|Sum of active process rates" id="395" />
+            <Map s="Neighborhoods|Lumen_lje_LowerJejunum_pls|MOLECULE|Sum of passive process rates" id="396" />
+            <Map s="Neighborhoods|Lumen_lje_LowerJejunum_cell|MOLECULE|Sum of passive process rates" id="397" />
+            <Map s="..|..|LowerJejunum|Fractional steady state fill level" id="398" />
+            <Map s="..|..|LowerJejunum|Intestinal transit rate (absolute)" id="399" />
+            <Map s="..|..|LowerJejunum|Volume" id="400" />
+            <Map s="LT_uil" id="401" />
+            <Map s="..|..|LowerJejunum|Liquid transfer rate" id="402" />
+            <Map s="..|..|LowerIleum|FillLevelFlag" id="403" />
+            <Map s="Neighborhoods|Lumen_uil_UpperIleum_pls|MOLECULE|Sum of active process rates" id="404" />
+            <Map s="Neighborhoods|Lumen_uil_UpperIleum_cell|MOLECULE|Sum of active process rates" id="405" />
+            <Map s="Neighborhoods|Lumen_uil_UpperIleum_pls|MOLECULE|Sum of passive process rates" id="406" />
+            <Map s="Neighborhoods|Lumen_uil_UpperIleum_cell|MOLECULE|Sum of passive process rates" id="407" />
+            <Map s="..|..|UpperIleum|Fractional steady state fill level" id="408" />
+            <Map s="..|..|UpperIleum|Intestinal transit rate (absolute)" id="409" />
+            <Map s="..|..|UpperIleum|Volume" id="410" />
+            <Map s="LT_lil" id="411" />
+            <Map s="..|..|UpperIleum|Liquid transfer rate" id="412" />
+            <Map s="..|..|Caecum|FillLevelFlag" id="413" />
+            <Map s="Neighborhoods|Lumen_lil_LowerIleum_pls|MOLECULE|Sum of active process rates" id="414" />
+            <Map s="Neighborhoods|Lumen_lil_LowerIleum_cell|MOLECULE|Sum of active process rates" id="415" />
+            <Map s="Neighborhoods|Lumen_lil_LowerIleum_pls|MOLECULE|Sum of passive process rates" id="416" />
+            <Map s="Neighborhoods|Lumen_lil_LowerIleum_cell|MOLECULE|Sum of passive process rates" id="417" />
+            <Map s="..|..|LowerIleum|Fractional steady state fill level" id="418" />
+            <Map s="..|..|LowerIleum|Intestinal transit rate (absolute)" id="419" />
+            <Map s="..|..|LowerIleum|Volume" id="420" />
+            <Map s="Organism|LargeIntestine|Large intestinal transit time factor" id="421" />
+            <Map s="LITT_fact" id="422" />
+            <Map s="LT_cae" id="423" />
+            <Map s="..|..|LowerIleum|Liquid transfer rate" id="424" />
+            <Map s="..|..|ColonAscendens|FillLevelFlag" id="425" />
+            <Map s="Organism|LargeIntestine|Volume" id="426" />
+            <Map s="Neighborhoods|Lumen_cae_Caecum_pls|MOLECULE|Sum of active process rates" id="427" />
+            <Map s="Neighborhoods|Lumen_cae_Caecum_cell|MOLECULE|Sum of active process rates" id="428" />
+            <Map s="Neighborhoods|Lumen_cae_Caecum_pls|MOLECULE|Sum of passive process rates" id="429" />
+            <Map s="Neighborhoods|Lumen_cae_Caecum_cell|MOLECULE|Sum of passive process rates" id="430" />
+            <Map s="..|..|Caecum|Fractional steady state fill level" id="431" />
+            <Map s="..|..|Caecum|Intestinal transit rate (absolute)" id="432" />
+            <Map s="..|..|Caecum|Volume" id="433" />
+            <Map s="LT_colasc" id="434" />
+            <Map s="..|..|Caecum|Liquid transfer rate" id="435" />
+            <Map s="..|..|ColonTransversum|FillLevelFlag" id="436" />
+            <Map s="Neighborhoods|Lumen_colasc_ColonAscendens_pls|MOLECULE|Sum of active process rates" id="437" />
+            <Map s="Neighborhoods|Lumen_colasc_ColonAscendens_cell|MOLECULE|Sum of active process rates" id="438" />
+            <Map s="Neighborhoods|Lumen_colasc_ColonAscendens_pls|MOLECULE|Sum of passive process rates" id="439" />
+            <Map s="Neighborhoods|Lumen_colasc_ColonAscendens_cell|MOLECULE|Sum of passive process rates" id="440" />
+            <Map s="..|..|ColonAscendens|Fractional steady state fill level" id="441" />
+            <Map s="..|..|ColonAscendens|Intestinal transit rate (absolute)" id="442" />
+            <Map s="..|..|ColonAscendens|Volume" id="443" />
+            <Map s="LT_coltrans" id="444" />
+            <Map s="..|..|ColonAscendens|Liquid transfer rate" id="445" />
+            <Map s="..|..|ColonDescendens|FillLevelFlag" id="446" />
+            <Map s="Neighborhoods|Lumen_coltrans_ColonTransversum_pls|MOLECULE|Sum of active process rates" id="447" />
+            <Map s="Neighborhoods|Lumen_coltrans_ColonTransversum_cell|MOLECULE|Sum of active process rates" id="448" />
+            <Map s="Neighborhoods|Lumen_coltrans_ColonTransversum_pls|MOLECULE|Sum of passive process rates" id="449" />
+            <Map s="Neighborhoods|Lumen_coltrans_ColonTransversum_cell|MOLECULE|Sum of passive process rates" id="450" />
+            <Map s="..|..|ColonTransversum|Fractional steady state fill level" id="451" />
+            <Map s="..|..|ColonTransversum|Intestinal transit rate (absolute)" id="452" />
+            <Map s="..|..|ColonTransversum|Volume" id="453" />
+            <Map s="LT_coldesc" id="454" />
+            <Map s="..|..|ColonTransversum|Liquid transfer rate" id="455" />
+            <Map s="..|..|ColonSigmoid|FillLevelFlag" id="456" />
+            <Map s="Neighborhoods|Lumen_coldesc_ColonDescendens_pls|MOLECULE|Sum of active process rates" id="457" />
+            <Map s="Neighborhoods|Lumen_coldesc_ColonDescendens_cell|MOLECULE|Sum of active process rates" id="458" />
+            <Map s="Neighborhoods|Lumen_coldesc_ColonDescendens_pls|MOLECULE|Sum of passive process rates" id="459" />
+            <Map s="Neighborhoods|Lumen_coldesc_ColonDescendens_cell|MOLECULE|Sum of passive process rates" id="460" />
+            <Map s="..|..|ColonDescendens|Fractional steady state fill level" id="461" />
+            <Map s="..|..|ColonDescendens|Intestinal transit rate (absolute)" id="462" />
+            <Map s="..|..|ColonDescendens|Volume" id="463" />
+            <Map s="LT_colsigm" id="464" />
+            <Map s="..|..|ColonDescendens|Liquid transfer rate" id="465" />
+            <Map s="..|..|Rectum|FillLevelFlag" id="466" />
+            <Map s="Neighborhoods|Lumen_colsigm_ColonSigmoid_pls|MOLECULE|Sum of active process rates" id="467" />
+            <Map s="Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|MOLECULE|Sum of active process rates" id="468" />
+            <Map s="Neighborhoods|Lumen_colsigm_ColonSigmoid_pls|MOLECULE|Sum of passive process rates" id="469" />
+            <Map s="Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|MOLECULE|Sum of passive process rates" id="470" />
+            <Map s="..|..|ColonSigmoid|Fractional steady state fill level" id="471" />
+            <Map s="..|..|ColonSigmoid|Intestinal transit rate (absolute)" id="472" />
+            <Map s="..|..|ColonSigmoid|Volume" id="473" />
+            <Map s="LT_rect" id="474" />
+            <Map s="..|..|ColonSigmoid|Liquid transfer rate" id="475" />
+            <Map s="Neighborhoods|Lumen_rect_Rectum_pls|MOLECULE|Sum of active process rates" id="476" />
+            <Map s="Neighborhoods|Lumen_rect_Rectum_cell|MOLECULE|Sum of active process rates" id="477" />
+            <Map s="Neighborhoods|Lumen_rect_Rectum_pls|MOLECULE|Sum of passive process rates" id="478" />
+            <Map s="Neighborhoods|Lumen_rect_Rectum_cell|MOLECULE|Sum of passive process rates" id="479" />
+            <Map s="..|..|Rectum|Liquid transfer rate" id="480" />
+            <Map s="LT_rec" id="481" />
+            <Map s="Neighborhoods|Stomach_pls_Stomach_int|Surface area (plasma/interstitial)" id="482" />
+            <Map s="Neighborhoods|Stomach_int_Stomach_cell|MOLECULE|Partition coefficient (interstitial/water)" id="483" />
+            <Map s="Neighborhoods|Stomach_int_Stomach_cell|MOLECULE|Partition coefficient (intracellular/water)" id="484" />
+            <Map s="..|Small intestinal transit time" id="485" />
+            <Map s="SITT" id="486" />
+            <Map s="..|Small intestinal transit time factor intercept" id="487" />
+            <Map s="P2" id="488" />
+            <Map s="..|Small intestinal transit time factor slope" id="489" />
+            <Map s="P1" id="490" />
+            <Map s="..|Fluid recirculation flow rate (incl. mucosa)" id="491" />
+            <Map s="J_iso_incl_Mucosa" id="492" />
+            <Map s="..|Mucosa|Duodenum|Fluid recirculation flow rate" id="493" />
+            <Map s="J_iso_duo" id="494" />
+            <Map s="..|Mucosa|LowerIleum|Fluid recirculation flow rate" id="495" />
+            <Map s="J_iso_lil" id="496" />
+            <Map s="..|Mucosa|LowerJejunum|Fluid recirculation flow rate" id="497" />
+            <Map s="J_iso_lje" id="498" />
+            <Map s="..|Mucosa|UpperIleum|Fluid recirculation flow rate" id="499" />
+            <Map s="J_iso_uil" id="500" />
+            <Map s="..|Mucosa|UpperJejunum|Fluid recirculation flow rate" id="501" />
+            <Map s="J_iso_uje" id="502" />
+            <Map s="..|Lymph flow rate (incl. mucosa)" id="503" />
+            <Map s="Q_lymph_incl_Mucosa" id="504" />
+            <Map s="..|Mucosa|Duodenum|Lymph flow rate" id="505" />
+            <Map s="Q_lymph_duo" id="506" />
+            <Map s="..|Mucosa|LowerIleum|Lymph flow rate" id="507" />
+            <Map s="Q_lymph_lil" id="508" />
+            <Map s="..|Mucosa|LowerJejunum|Lymph flow rate" id="509" />
+            <Map s="Q_lymph_lje" id="510" />
+            <Map s="..|Mucosa|UpperIleum|Lymph flow rate" id="511" />
+            <Map s="Q_lymph_uil" id="512" />
+            <Map s="..|Mucosa|UpperJejunum|Lymph flow rate" id="513" />
+            <Map s="Q_lymph_uje" id="514" />
+            <Map s="Neighborhoods|SmallIntestine_pls_SmallIntestine_int|Surface area (plasma/interstitial)" id="515" />
+            <Map s="..|Mucosa|Duodenum|Volume" id="516" />
+            <Map s="V_duo" id="517" />
+            <Map s="..|Mucosa|LowerIleum|Volume" id="518" />
+            <Map s="V_lil" id="519" />
+            <Map s="..|Mucosa|LowerJejunum|Volume" id="520" />
+            <Map s="V_lje" id="521" />
+            <Map s="..|Mucosa|UpperIleum|Volume" id="522" />
+            <Map s="V_uil" id="523" />
+            <Map s="..|Mucosa|UpperJejunum|Volume" id="524" />
+            <Map s="V_uje" id="525" />
+            <Map s="..|..|Volume (mucosa)" id="526" />
+            <Map s="V_Mucosa" id="527" />
+            <Map s="Neighborhoods|SmallIntestine_int_SmallIntestine_cell|MOLECULE|Partition coefficient (interstitial/water)" id="528" />
+            <Map s="Neighborhoods|SmallIntestine_int_SmallIntestine_cell|MOLECULE|Partition coefficient (intracellular/water)" id="529" />
+            <Map s="..|Fraction mucosa" id="530" />
+            <Map s="fractionMucosa" id="531" />
+            <Map s="..|..|..|..|Lumen|Duodenum|Volume (gut wall)" id="532" />
+            <Map s="V_GutWall" id="533" />
+            <Map s="..|..|..|Fluid recirculation flow rate (incl. mucosa)" id="534" />
+            <Map s="J_iso_intestine" id="535" />
+            <Map s="..|..|..|Volume" id="536" />
+            <Map s="V_intestine" id="537" />
+            <Map s="V_seg" id="538" />
+            <Map s="..|..|..|Lymph flow rate (incl. mucosa)" id="539" />
+            <Map s="Q_lymph_intestine" id="540" />
+            <Map s="Neighborhoods|Duodenum_pls_Duodenum_int|Surface area (plasma/interstitial)" id="541" />
+            <Map s="..|..|..|Blood flow rate" id="542" />
+            <Map s="..|Fraction of regional blood flow rate" id="543" />
+            <Map s="regionalFractQ" id="544" />
+            <Map s="..|..|..|Mucosa blood flow fraction" id="545" />
+            <Map s="fractQ" id="546" />
+            <Map s="Neighborhoods|Duodenum_int_Duodenum_cell|MOLECULE|Partition coefficient (interstitial/water)" id="547" />
+            <Map s="Neighborhoods|Duodenum_int_Duodenum_cell|MOLECULE|Partition coefficient (intracellular/water)" id="548" />
+            <Map s="..|..|..|..|Lumen|UpperJejunum|Volume (gut wall)" id="549" />
+            <Map s="Neighborhoods|UpperJejunum_pls_UpperJejunum_int|Surface area (plasma/interstitial)" id="550" />
+            <Map s="Neighborhoods|UpperJejunum_int_UpperJejunum_cell|MOLECULE|Partition coefficient (interstitial/water)" id="551" />
+            <Map s="Neighborhoods|UpperJejunum_int_UpperJejunum_cell|MOLECULE|Partition coefficient (intracellular/water)" id="552" />
+            <Map s="..|..|..|..|Lumen|LowerJejunum|Volume (gut wall)" id="553" />
+            <Map s="Neighborhoods|LowerJejunum_pls_LowerJejunum_int|Surface area (plasma/interstitial)" id="554" />
+            <Map s="Neighborhoods|LowerJejunum_int_LowerJejunum_cell|MOLECULE|Partition coefficient (interstitial/water)" id="555" />
+            <Map s="Neighborhoods|LowerJejunum_int_LowerJejunum_cell|MOLECULE|Partition coefficient (intracellular/water)" id="556" />
+            <Map s="..|..|..|..|Lumen|UpperIleum|Volume (gut wall)" id="557" />
+            <Map s="Neighborhoods|UpperIleum_pls_UpperIleum_int|Surface area (plasma/interstitial)" id="558" />
+            <Map s="Neighborhoods|UpperIleum_int_UpperIleum_cell|MOLECULE|Partition coefficient (interstitial/water)" id="559" />
+            <Map s="Neighborhoods|UpperIleum_int_UpperIleum_cell|MOLECULE|Partition coefficient (intracellular/water)" id="560" />
+            <Map s="..|..|..|..|Lumen|LowerIleum|Volume (gut wall)" id="561" />
+            <Map s="Neighborhoods|LowerIleum_pls_LowerIleum_int|Surface area (plasma/interstitial)" id="562" />
+            <Map s="Neighborhoods|LowerIleum_int_LowerIleum_cell|MOLECULE|Partition coefficient (interstitial/water)" id="563" />
+            <Map s="Neighborhoods|LowerIleum_int_LowerIleum_cell|MOLECULE|Partition coefficient (intracellular/water)" id="564" />
+            <Map s="..|Large intestinal transit time" id="565" />
+            <Map s="LITT" id="566" />
+            <Map s="..|Large intestinal transit time factor intercept" id="567" />
+            <Map s="..|Large intestinal transit time factor slope" id="568" />
+            <Map s="..|Mucosa|Caecum|Volume" id="569" />
+            <Map s="V_cae" id="570" />
+            <Map s="..|Mucosa|ColonAscendens|Volume" id="571" />
+            <Map s="V_ca" id="572" />
+            <Map s="..|Mucosa|ColonDescendens|Volume" id="573" />
+            <Map s="V_cd" id="574" />
+            <Map s="..|Mucosa|ColonSigmoid|Volume" id="575" />
+            <Map s="V_cs" id="576" />
+            <Map s="..|Mucosa|ColonTransversum|Volume" id="577" />
+            <Map s="V_ct" id="578" />
+            <Map s="..|Mucosa|Rectum|Volume" id="579" />
+            <Map s="V_rec" id="580" />
+            <Map s="..|Mucosa|Caecum|Fluid recirculation flow rate" id="581" />
+            <Map s="J_iso_cae" id="582" />
+            <Map s="..|Mucosa|ColonAscendens|Fluid recirculation flow rate" id="583" />
+            <Map s="J_iso_colasc" id="584" />
+            <Map s="..|Mucosa|ColonDescendens|Fluid recirculation flow rate" id="585" />
+            <Map s="J_iso_coldesc" id="586" />
+            <Map s="..|Mucosa|ColonSigmoid|Fluid recirculation flow rate" id="587" />
+            <Map s="J_iso_colsigm" id="588" />
+            <Map s="..|Mucosa|ColonTransversum|Fluid recirculation flow rate" id="589" />
+            <Map s="J_iso_coltrans" id="590" />
+            <Map s="..|Mucosa|Rectum|Fluid recirculation flow rate" id="591" />
+            <Map s="J_iso_rect" id="592" />
+            <Map s="..|Mucosa|Caecum|Lymph flow rate" id="593" />
+            <Map s="Q_lymph_cae" id="594" />
+            <Map s="..|Mucosa|ColonAscendens|Lymph flow rate" id="595" />
+            <Map s="Q_lymph_colasc" id="596" />
+            <Map s="..|Mucosa|ColonDescendens|Lymph flow rate" id="597" />
+            <Map s="Q_lymph_coldesc" id="598" />
+            <Map s="..|Mucosa|ColonSigmoid|Lymph flow rate" id="599" />
+            <Map s="Q_lymph_colsigm" id="600" />
+            <Map s="..|Mucosa|ColonTransversum|Lymph flow rate" id="601" />
+            <Map s="Q_lymph_coltrans" id="602" />
+            <Map s="..|Mucosa|Rectum|Lymph flow rate" id="603" />
+            <Map s="Q_lymph_rect" id="604" />
+            <Map s="Neighborhoods|LargeIntestine_pls_LargeIntestine_int|Surface area (plasma/interstitial)" id="605" />
+            <Map s="Neighborhoods|LargeIntestine_int_LargeIntestine_cell|MOLECULE|Partition coefficient (interstitial/water)" id="606" />
+            <Map s="Neighborhoods|LargeIntestine_int_LargeIntestine_cell|MOLECULE|Partition coefficient (intracellular/water)" id="607" />
+            <Map s="..|..|..|..|Lumen|Caecum|Volume (gut wall)" id="608" />
+            <Map s="Neighborhoods|Caecum_pls_Caecum_int|Surface area (plasma/interstitial)" id="609" />
+            <Map s="Neighborhoods|Caecum_int_Caecum_cell|MOLECULE|Partition coefficient (interstitial/water)" id="610" />
+            <Map s="Neighborhoods|Caecum_int_Caecum_cell|MOLECULE|Partition coefficient (intracellular/water)" id="611" />
+            <Map s="..|..|..|..|Lumen|ColonAscendens|Volume (gut wall)" id="612" />
+            <Map s="Neighborhoods|ColonAscendens_pls_ColonAscendens_int|Surface area (plasma/interstitial)" id="613" />
+            <Map s="Neighborhoods|ColonAscendens_int_ColonAscendens_cell|MOLECULE|Partition coefficient (interstitial/water)" id="614" />
+            <Map s="Neighborhoods|ColonAscendens_int_ColonAscendens_cell|MOLECULE|Partition coefficient (intracellular/water)" id="615" />
+            <Map s="..|..|..|..|Lumen|ColonTransversum|Volume (gut wall)" id="616" />
+            <Map s="Neighborhoods|ColonTransversum_pls_ColonTransversum_int|Surface area (plasma/interstitial)" id="617" />
+            <Map s="Neighborhoods|ColonTransversum_int_ColonTransversum_cell|MOLECULE|Partition coefficient (interstitial/water)" id="618" />
+            <Map s="Neighborhoods|ColonTransversum_int_ColonTransversum_cell|MOLECULE|Partition coefficient (intracellular/water)" id="619" />
+            <Map s="..|..|..|..|Lumen|ColonDescendens|Volume (gut wall)" id="620" />
+            <Map s="Neighborhoods|ColonDescendens_pls_ColonDescendens_int|Surface area (plasma/interstitial)" id="621" />
+            <Map s="Neighborhoods|ColonDescendens_int_ColonDescendens_cell|MOLECULE|Partition coefficient (interstitial/water)" id="622" />
+            <Map s="Neighborhoods|ColonDescendens_int_ColonDescendens_cell|MOLECULE|Partition coefficient (intracellular/water)" id="623" />
+            <Map s="..|..|..|..|Lumen|ColonSigmoid|Volume (gut wall)" id="624" />
+            <Map s="Neighborhoods|ColonSigmoid_pls_ColonSigmoid_int|Surface area (plasma/interstitial)" id="625" />
+            <Map s="Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|MOLECULE|Partition coefficient (interstitial/water)" id="626" />
+            <Map s="Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|MOLECULE|Partition coefficient (intracellular/water)" id="627" />
+            <Map s="..|..|..|..|Lumen|Rectum|Volume (gut wall)" id="628" />
+            <Map s="Neighborhoods|Rectum_pls_Rectum_int|Surface area (plasma/interstitial)" id="629" />
+            <Map s="Neighborhoods|Rectum_int_Rectum_cell|MOLECULE|Partition coefficient (interstitial/water)" id="630" />
+            <Map s="Neighborhoods|Rectum_int_Rectum_cell|MOLECULE|Partition coefficient (intracellular/water)" id="631" />
+            <Map s="Neighborhoods|Liver_pls_Liver_int|Surface area (plasma/interstitial)" id="632" />
+            <Map s="..|..|Allometric scale factor" id="633" />
+            <Map s="Liver_Parameter" id="634" />
+            <Map s="..|..|Density (tissue)" id="635" />
+            <Map s="..|..|Fraction of blood for sampling" id="636" />
+            <Map s="Organism|Liver|Fraction of periportal zone" id="637" />
+            <Map s="f_periportal" id="638" />
+            <Map s="Organism|Liver|Is liver zonated" id="639" />
+            <Map s="IsLiverZonated" id="640" />
+            <Map s="Organism|Liver|Volume" id="641" />
+            <Map s="V_liv" id="642" />
+            <Map s="..|..|Flow fraction via large pores" id="643" />
+            <Map s="..|..|Fluid recirculation flow rate" id="644" />
+            <Map s="J_iso" id="645" />
+            <Map s="..|..|Hydraulic conductivity" id="646" />
+            <Map s="Hydraulic conductivity" id="647" />
+            <Map s="..|..|Lymph flow rate" id="648" />
+            <Map s="..|..|Radius (large pores)" id="649" />
+            <Map s="..|..|Radius (small pores)" id="650" />
+            <Map s="Neighborhoods|Periportal_pls_Periportal_int|Surface area (plasma/interstitial)" id="651" />
+            <Map s="..|..|Vf (lipid)" id="652" />
+            <Map s="..|..|Vf (neutral lipid)-PT" id="653" />
+            <Map s="..|..|Vf (phospholipid)-PT" id="654" />
+            <Map s="..|..|Vf (protein)" id="655" />
+            <Map s="..|..|Albumin ratio (tissue/plasma)" id="656" />
+            <Map s="..|..|Albumin ratio (tissue/plasma)-PT" id="657" />
+            <Map s="..|..|Lipoprotein ratio (tissue/plasma)" id="658" />
+            <Map s="..|..|Microsomal protein mass/g tissue" id="659" />
+            <Map s="Mass per tissue" id="660" />
+            <Map s="..|..|Number of cells/g tissue" id="661" />
+            <Map s="Count per mass" id="662" />
+            <Map s="..|..|Vf (water)" id="663" />
+            <Map s="..|..|Vf (water)-PT" id="664" />
+            <Map s="..|..|Vf (neutral lipid)-RR" id="665" />
+            <Map s="..|..|Vf (neutral lipid)-WS" id="666" />
+            <Map s="..|..|Vf (neutral phospholipid)-RR" id="667" />
+            <Map s="..|..|Vf (neutral phospholipid, plasma)-WS" id="668" />
+            <Map s="..|..|Vf (extracellular water)-RR" id="669" />
+            <Map s="..|..|Vf (protein)-WS" id="670" />
+            <Map s="..|..|Vf (intracellular water)-RR" id="671" />
+            <Map s="..|..|Vf (water)-WS" id="672" />
+            <Map s="..|..|Acidic phospholipids [mg/g] - RR" id="673" />
+            <Map s="..|..|Vf (acidic phospholipids)-WS" id="674" />
+            <Map s="..|..|Specific blood flow rate" id="675" />
+            <Map s="..|..|Blood flow rate" id="676" />
+            <Map s="Neighborhoods|Periportal_int_Periportal_cell|MOLECULE|Partition coefficient (interstitial/water)" id="677" />
+            <Map s="Organism|Liver|Intracellular|pH" id="678" />
+            <Map s="pH_cell_Liver" id="679" />
+            <Map s="Neighborhoods|Periportal_int_Periportal_cell|MOLECULE|Partition coefficient (intracellular/water)" id="680" />
+            <Map s="Neighborhoods|Pericentral_pls_Pericentral_int|Surface area (plasma/interstitial)" id="681" />
+            <Map s="Neighborhoods|Lung_pls_Lung_int|Surface area (plasma/interstitial)" id="682" />
+            <Map s="Organism|Bone|Blood flow rate" id="683" />
+            <Map s="Q_bon" id="684" />
+            <Map s="Organism|Brain|Blood flow rate" id="685" />
+            <Map s="Q_brn" id="686" />
+            <Map s="Organism|Fat|Blood flow rate" id="687" />
+            <Map s="Q_fat" id="688" />
+            <Map s="Organism|Gonads|Blood flow rate" id="689" />
+            <Map s="Q_tes" id="690" />
+            <Map s="Organism|Heart|Blood flow rate" id="691" />
+            <Map s="Q_hrt" id="692" />
+            <Map s="Organism|Kidney|Blood flow rate" id="693" />
+            <Map s="Q_kid" id="694" />
+            <Map s="Organism|LargeIntestine|Blood flow rate" id="695" />
+            <Map s="Q_lin" id="696" />
+            <Map s="Organism|Liver|Blood flow rate" id="697" />
+            <Map s="Q_liv" id="698" />
+            <Map s="Organism|Muscle|Blood flow rate" id="699" />
+            <Map s="Q_mus" id="700" />
+            <Map s="Organism|Pancreas|Blood flow rate" id="701" />
+            <Map s="Q_pan" id="702" />
+            <Map s="Organism|Skin|Blood flow rate" id="703" />
+            <Map s="Q_skn" id="704" />
+            <Map s="Organism|SmallIntestine|Blood flow rate" id="705" />
+            <Map s="Q_sin" id="706" />
+            <Map s="Organism|Spleen|Blood flow rate" id="707" />
+            <Map s="Q_spl" id="708" />
+            <Map s="Organism|Stomach|Blood flow rate" id="709" />
+            <Map s="Q_sto" id="710" />
+            <Map s="Neighborhoods|Lung_int_Lung_cell|MOLECULE|Partition coefficient (interstitial/water)" id="711" />
+            <Map s="Neighborhoods|Lung_int_Lung_cell|MOLECULE|Partition coefficient (intracellular/water)" id="712" />
+            <Map s="Neighborhoods|Muscle_pls_Muscle_int|Surface area (plasma/interstitial)" id="713" />
+            <Map s="Neighborhoods|Muscle_int_Muscle_cell|MOLECULE|Partition coefficient (interstitial/water)" id="714" />
+            <Map s="Neighborhoods|Muscle_int_Muscle_cell|MOLECULE|Partition coefficient (intracellular/water)" id="715" />
+            <Map s="Neighborhoods|Pancreas_pls_Pancreas_int|Surface area (plasma/interstitial)" id="716" />
+            <Map s="Neighborhoods|Pancreas_int_Pancreas_cell|MOLECULE|Partition coefficient (interstitial/water)" id="717" />
+            <Map s="Neighborhoods|Pancreas_int_Pancreas_cell|MOLECULE|Partition coefficient (intracellular/water)" id="718" />
+            <Map s="Organism|LargeIntestine|Lymph flow rate (incl. mucosa)" id="719" />
+            <Map s="Q_Lymph_lin_incl_Mucosa" id="720" />
+            <Map s="Organism|Pancreas|Lymph flow rate" id="721" />
+            <Map s="Q_Lymph_pan" id="722" />
+            <Map s="Organism|SmallIntestine|Lymph flow rate (incl. mucosa)" id="723" />
+            <Map s="Q_Lymph_sin_incl_Mucosa" id="724" />
+            <Map s="Organism|Spleen|Lymph flow rate" id="725" />
+            <Map s="Q_Lymph_spl" id="726" />
+            <Map s="Organism|Stomach|Lymph flow rate" id="727" />
+            <Map s="Q_Lymph_sto" id="728" />
+            <Map s="Neighborhoods|Skin_pls_Skin_int|Surface area (plasma/interstitial)" id="729" />
+            <Map s="Neighborhoods|Skin_int_Skin_cell|MOLECULE|Partition coefficient (interstitial/water)" id="730" />
+            <Map s="Neighborhoods|Skin_int_Skin_cell|MOLECULE|Partition coefficient (intracellular/water)" id="731" />
+            <Map s="Neighborhoods|Spleen_pls_Spleen_int|Surface area (plasma/interstitial)" id="732" />
+            <Map s="Neighborhoods|Spleen_int_Spleen_cell|MOLECULE|Partition coefficient (interstitial/water)" id="733" />
+            <Map s="Neighborhoods|Spleen_int_Spleen_cell|MOLECULE|Partition coefficient (intracellular/water)" id="734" />
+            <Map s="Organism|Saliva|Volume" id="735" />
+            <Map s="V_slv" id="736" />
+            <Map s="FIRST_NEIGHBOR|..|Volume" id="737" />
+            <Map s="Organism|Surface/Volume ratio (blood cells)" id="738" />
+            <Map s="A_to_V_bc" id="739" />
+            <Map s="V_bon" id="740" />
+            <Map s="..|P_int_cell_factor" id="741" />
+            <Map s="P_int_cell_factor" id="742" />
+            <Map s="..|P_cell_int_factor" id="743" />
+            <Map s="P_cell_int_factor" id="744" />
+            <Map s="..|P (interstitial-&gt;intracellular)" id="745" />
+            <Map s="P_int_cell" id="746" />
+            <Map s="..|..|Surface area (interstitial/intracellular)" id="747" />
+            <Map s="SA" id="748" />
+            <Map s="..|P (intracellular-&gt;interstitial)" id="749" />
+            <Map s="P_cell_int" id="750" />
+            <Map s="..|Partition coefficient (intracellular/plasma)" id="751" />
+            <Map s="K_cell_pls" id="752" />
+            <Map s="FIRST_NEIGHBOR|..|Fraction vascular" id="753" />
+            <Map s="f_vas_org" id="754" />
+            <Map s="Organism|SA proportionality factor" id="755" />
+            <Map s="V_brn" id="756" />
+            <Map s="V_fat" id="757" />
+            <Map s="V_tes" id="758" />
+            <Map s="V_hrt" id="759" />
+            <Map s="V_kid" id="760" />
+            <Map s="FIRST_NEIGHBOR|Effective surface area" id="761" />
+            <Map s="Aeff" id="762" />
+            <Map s="SECOND_NEIGHBOR|MOLECULE|Concentration" id="763" />
+            <Map s="DrugMucosa" id="764" />
+            <Map s="Concentration (molar)" id="765" />
+            <Map s="FIRST_NEIGHBOR|MOLECULE|Effective concentration in lumen" id="766" />
+            <Map s="EffectiveLumenConcentration" id="767" />
+            <Map s="MOLECULE|Intestinal permeability (paracellular)" id="768" />
+            <Map s="P_int_para" id="769" />
+            <Map s="FIRST_NEIGHBOR|..|OralApplicationsEnabled" id="770" />
+            <Map s="FIRST_NEIGHBOR|..|Paracellular absorption sink condition" id="771" />
+            <Map s="SinkCondition_para" id="772" />
+            <Map s="MOLECULE|Intestinal permeability (transcellular)" id="773" />
+            <Map s="NEIGHBORHOOD|MOLECULE|P_int_trans_cell_lum_factor" id="774" />
+            <Map s="P_int_trans_cell_lum_factor" id="775" />
+            <Map s="NEIGHBORHOOD|MOLECULE|P_int_trans_lum_cell_factor" id="776" />
+            <Map s="P_int_trans_lum_cell_factor" id="777" />
+            <Map s="FIRST_NEIGHBOR|..|Transcellular absorption sink condition" id="778" />
+            <Map s="SinkCondition_trans" id="779" />
+            <Map s="..|pKa_pH_WS_cell_K1" id="780" />
+            <Map s="..|pKa_pH_WS_cell_K2" id="781" />
+            <Map s="..|pKa_pH_WS_cell_K3" id="782" />
+            <Map s="..|pKa_pH_WS_cell_K4" id="783" />
+            <Map s="..|pKa_pH_WS_cell_K5" id="784" />
+            <Map s="..|pKa_pH_WS_cell_K6" id="785" />
+            <Map s="..|pKa_pH_WS_cell_K7" id="786" />
+            <Map s="..|pKa_pH_WS_cell_K8" id="787" />
+            <Map s="MOLECULE|Use pH- and pKa-dependent penalty factor for charged molecule fraction" id="788" />
+            <Map s="UsePenaltyFactor" id="789" />
+            <Map s="MOLECULE|base_For_Pint_Factor" id="790" />
+            <Map s="Neighborhoods|UpperJejunum_int_UpperJejunum_cell|MOLECULE|Partition coefficient (intracellular/plasma)" id="791" />
+            <Map s="SECOND_NEIGHBOR|pH" id="792" />
+            <Map s="..|pKa_pH_WS_cell_F1" id="793" />
+            <Map s="..|pKa_pH_WS_cell_F2" id="794" />
+            <Map s="..|pKa_pH_WS_cell_F3" id="795" />
+            <Map s="FIRST_NEIGHBOR|pH" id="796" />
+            <Map s="FIRST_NEIGHBOR|MOLECULE|Concentration" id="797" />
+            <Map s="C_pls" id="798" />
+            <Map s="FIRST_NEIGHBOR|..|Blood flow rate" id="799" />
+            <Map s="C_bc" id="800" />
+            <Map s="Neighborhoods|LowerJejunum_int_LowerJejunum_cell|MOLECULE|Partition coefficient (intracellular/plasma)" id="801" />
+            <Map s="Organism|Lumen|Caecum|MOLECULE|Oral mass absorbed segment" id="802" />
+            <Map s="MAbs_cae" id="803" />
+            <Map s="Organism|Lumen|ColonAscendens|MOLECULE|Oral mass absorbed segment" id="804" />
+            <Map s="MAbs_colasc" id="805" />
+            <Map s="Organism|Lumen|ColonDescendens|MOLECULE|Oral mass absorbed segment" id="806" />
+            <Map s="MAbs_coldesc" id="807" />
+            <Map s="Organism|Lumen|ColonSigmoid|MOLECULE|Oral mass absorbed segment" id="808" />
+            <Map s="MAbs_colsigm" id="809" />
+            <Map s="Organism|Lumen|ColonTransversum|MOLECULE|Oral mass absorbed segment" id="810" />
+            <Map s="MAbs_coltrans" id="811" />
+            <Map s="Organism|Lumen|Duodenum|MOLECULE|Oral mass absorbed segment" id="812" />
+            <Map s="MAbs_duo" id="813" />
+            <Map s="Organism|Lumen|LowerIleum|MOLECULE|Oral mass absorbed segment" id="814" />
+            <Map s="MAbs_lil" id="815" />
+            <Map s="Organism|Lumen|LowerJejunum|MOLECULE|Oral mass absorbed segment" id="816" />
+            <Map s="MAbs_lje" id="817" />
+            <Map s="Organism|Lumen|Rectum|MOLECULE|Oral mass absorbed segment" id="818" />
+            <Map s="MAbs_rect" id="819" />
+            <Map s="Organism|Lumen|UpperIleum|MOLECULE|Oral mass absorbed segment" id="820" />
+            <Map s="MAbs_uil" id="821" />
+            <Map s="Organism|Lumen|UpperJejunum|MOLECULE|Oral mass absorbed segment" id="822" />
+            <Map s="MAbs_uje" id="823" />
+            <Map s="V_sto" id="824" />
+            <Map s="Neighborhoods|UpperIleum_int_UpperIleum_cell|MOLECULE|Partition coefficient (intracellular/plasma)" id="825" />
+            <Map s="V_sin" id="826" />
+            <Map s="Organism|SmallIntestine|Volume (mucosa)" id="827" />
+            <Map s="FIRST_NEIGHBOR|..|Volume (mucosa)" id="828" />
+            <Map s="SECOND_NEIGHBOR|..|Blood flow rate" id="829" />
+            <Map s="Neighborhoods|LowerIleum_int_LowerIleum_cell|MOLECULE|Partition coefficient (intracellular/plasma)" id="830" />
+            <Map s="V_lin" id="831" />
+            <Map s="Organism|LargeIntestine|Volume (mucosa)" id="832" />
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+            <QuantitySelection path="Organism|ArterialBlood|Plasma|Aciclovir|Plasma Unbound" quantityType="Drug, Observer" />
+            <QuantitySelection path="Organism|ArterialBlood|BloodCells|Aciclovir|Concentration in container" quantityType="Drug, Observer" />
+            <QuantitySelection path="Organism|ArterialBlood|Aciclovir|Whole Blood" quantityType="Drug, Observer" />
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+              <Map s="FIRST_NEIGHBOR|..|Vf (lipid)" id="14" />
+              <Map s="f_lipids" id="15" />
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+              <Parameter id="2mg0hlcyoUWQ9FRbzNkD8Q" name="Vf (water,plasma)" description="Fractional volume content of water in plasma used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.926">
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+              </Parameter>
+              <Parameter id="noKCUMpsQ0mDW0vjYKvNhg" name="Surface/Volume ratio (blood cells)" description="Surface area to volume ratio of blood cells" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="167000" displayUnit="1/cm">
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+              </Parameter>
+              <Parameter id="tg7Ymi96NUigjRgBg_JGSA" name="Vf (neutral lipid, plasma)-PT" description="Fractional volume content of neutral lipid in plasma used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0035">
+                <Info min="0" max="1" flag="122" seq="2" ref="0" bb="32" group="86" />
+              </Parameter>
+              <Parameter id="80GZkohPzUunyJQbVtWr7w" name="Vf (neutral phospholipid, blood cells)-WS" description="Fractional volume content of neutral phospholipid in blood cells used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0059">
+                <Info min="0" max="1" flag="122" seq="2" ref="0" bb="32" group="95" />
+              </Parameter>
+              <Parameter id="KGIBZzTI50uQXC7c6-237w" name="Vf (neutral phospholipid, plasma)-RR" description="Fractional volume content of neutral phospholipid in plasma used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0021">
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+                <Info min="0" max="25" flag="62" seq="3" ref="0" bb="32" group="6" />
+              </Parameter>
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+                <Info min="0" flag="42" seq="3" ref="0" bb="32" group="142" />
+              </Parameter>
+              <Parameter id="flujZMXuxUGhV2uOlcIzMw" name="Plasma protein scale factor" description="Scale factor for the fraction unbound in plasma. This factor can be used if changes in the plasma protein concentration and, as a result, in the plasma protein binding of the drug are expected due to e.g. ageing or certain diseases such as cirrhosis, sepsis, or renal failure" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
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+                <ValueOrigin id="23" source="Publication" description="Rodgers T, Rowland M. Mechanistic approaches to volume of distribution predictions: understanding the processes. Pharm Res. 2007 May;24(5):918-33. https://doi.org/10.1007/s11095-006-9210-3" />
+                <Info min="0" max="1" flag="122" seq="6" ref="0" bb="32" group="92" />
+              </Parameter>
+              <Parameter id="gcgIdmREJka7j46fKItoyg" name="Rate constant for endosomal uptake (global)" description="Rate constant for endosomal uptake for all organs" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.294" displayUnit="1/min">
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+                <Children>
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+                    <Info min="0" flag="18" seq="1" ref="0" bb="32" group="6" />
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+                    <Info min="0" flag="34" seq="1" ref="0" bb="32" group="6" />
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+                <Children>
+                  <Parameter id="vPi4xK2VvEC4y5OP9-q3Tw" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                    <Info min="0" flag="18" seq="1" ref="0" bb="32" group="6" />
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+                    <Info min="0" flag="34" seq="1" ref="0" bb="32" group="6" />
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+                <Info min="0" flag="38" seq="3" ref="0" bb="32" group="6" />
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+              <Container id="PyL229qczUS50ZkpPVEuxg" name="PeripheralVenousBlood" description="Peripheral Venous Blood" icon="VenousBlood" mode="Logical" containerType="Organ">
+                <Children>
+                  <Container id="Kh_3uT0mdkKLT5U5jHt-EQ" name="Aciclovir" mode="Logical" containerType="Molecule">
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+              <Container id="BIcGJzX600qvmej60fiEvw" name="VenousBlood" description="VenousBlood" icon="VenousBlood" mode="Logical" containerType="Organ">
+                <Tags>
+                  <Tag value="BloodOrgan" />
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+                <Children>
+                  <Parameter id="xK1dhuWFi06KwjC5YTC1YA" name="Weight (tissue)" description="Weight of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="fliUWazsPUiRy_qjzM6EaA" isDefault="1" displayUnit="kg">
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+                    <Tags>
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+                      <Tag value="BloodOrgan" />
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+                    <Info min="0.75" max="0.75" flag="52" seq="1" ref="0" bb="32" group="2" />
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+                  <Parameter id="D0rxj8z4vUev5hgL6igpXQ" name="Fraction vascular" description="Fraction of vascular space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                    <Tags>
+                      <Tag value="BloodOrgan" />
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+                    <Info min="0" max="1" flag="62" seq="9" ref="0" bb="32" group="64" />
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+                  <DistributedParameter id="t4_rSjkeJ0ynjV2si6hg2Q" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="lJabNRMvzES8jYjUK-2ZoQ" mode="Logical" isDefault="1" displayUnit="l">
+                    <Children>
+                      <Parameter id="gPLByuM_xkuX92Kxu13YcQ" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.50097470344528">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="65" />
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+                      <Parameter id="Ursuarx-6E2Q5ozx10NHAw" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.963884723" displayUnit="l">
+                        <Info min="0" flag="34" seq="1" ref="0" bb="32" group="65" />
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+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="65" />
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+                      <Container id="bpXxtlLbOUms481AFsMT0w" name="Aciclovir" mode="Logical" containerType="Molecule" />
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+                    <Tags>
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+                    <Children>
+                      <Parameter id="EOhgRcd70EejcyaL_LWZ0g" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="WiDWMA7xi02WdVvl1Rjr0g" isDefault="1" displayUnit="l">
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+                        <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
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+                          <Parameter id="bjvv_82H4USeenWIUb49NA" name="Relative expression" description="Relative expression" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="fqrxyq94VkWMTLJeRjjhEQ" isDefault="1">
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+                          <Parameter id="3ufne8Hkmk-Moiq7ZftPCg" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="5E-2OY76xUaC7BsDYw6QVg" isDefault="1" displayUnit="min">
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+                        </Children>
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+                          <Parameter id="Rg2wfvnt90uD7kYWWFWHPw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="GabIBoJjY02yGA-bpJePLg" isDefault="1">
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+                      <Tag value="BloodOrgan" />
+                      <Tag value="VenousBlood" />
+                    </Tags>
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+                          <Parameter id="AawCVj4DEkqok3IctzBeQA" name="Degradation coefficient" description="First order turnover rate constant of the enzyme" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="c2fNMePAyki4XPdR-AEHaQ" isDefault="1" displayUnit="1/min">
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+                          <Parameter id="slQFQmha7E-xPMaHb1iUhw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="h0mklHy6S0eXhlX4vvP24A" isDefault="1">
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+                        </Children>
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+              </Container>
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+                <Tags>
+                  <Tag value="BloodOrgan" />
+                </Tags>
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+                    <Tags>
+                      <Tag value="BloodOrgan" />
+                    </Tags>
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+                  </Parameter>
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+                    <Tags>
+                      <Tag value="BloodOrgan" />
+                    </Tags>
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+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="65" />
+                      </Parameter>
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+                          <Parameter id="cE-otZhcDEKwwAzSpcRJKw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="quHS5OFyjkGE8pPL8NEZhQ" isDefault="1">
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+                          <Observer id="3FZpXBS52UWMv_d7QfAgbg" name="Plasma Unbound" description="Plasma Unbound" icon="Observer" persistable="1" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" negativeValuesAllowed="1" formula="9ka5eYzDYES6SjBtwzrF0A" displayUnit="µmol/l" />
+                        </Children>
+                      </MoleculeAmount>
+                    </Children>
+                  </Container>
+                  <Container id="FtxmOVy3hEyMCuullB4l-A" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
+                    <Tags>
+                      <Tag value="ArterialBlood" />
+                      <Tag value="BloodOrgan" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="weXtoYMiD02qeIyTJVhQyw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="WiDWMA7xi02WdVvl1Rjr0g" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="HiBCm73750OxobAoLZD-Jw" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="bC13c4QML0S_zVvT6EvEXg" isDefault="1" displayUnit="l">
+                        <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                        <Info min="0" flag="62" seq="4" ref="0" bb="2" group="121" />
+                      </Parameter>
+                      <MoleculeAmount id="rXnZduFauE-_WmdbcqfH_g" name="CYP344" icon="ENZYME" persistable="0" isFixedValue="0" dim="Amount" quantityType="Enzyme" negativeValuesAllowed="0" formula="rMXLZglcaUaofPZ0c6I6Yw" mode="Logical" scaleDivisor="1" displayUnit="µmol">
+                        <Children>
+                          <Parameter id="yipNSfnDUkGlAYwUEes0dg" name="Degradation coefficient" description="First order turnover rate constant of the enzyme" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="c2fNMePAyki4XPdR-AEHaQ" isDefault="1" displayUnit="1/min">
+                            <ValueOrigin id="33" source="Other" description="OSP Suite Manual Chapter 16. PK-Sim®- Compounds: Defining inhibition/induction processes" />
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="AXrGPThL0UycopdZTmrU_w" name="Relative expression" description="Relative expression" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="cLw6IJb0kk-aHdh1YkXHkw" isDefault="1">
+                            <Info min="0" flag="60" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="M0PHSF84fEiQ68IqVCJQ3A" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="xTktpLRZC0e7-rlZenlyLg" isDefault="1">
+                            <Info min="0" flag="58" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="OOJoZkuXJ0Ouq-KKFImB5w" name="Relative expression out." description="Relative Expression that will be used in the simulation" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="fbRCNZOks0i0JlaOaYnbvg" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="91" />
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+                          <Parameter id="DIlWdXY8EU2y4RDkhJMxdg" name="Start amount" description="Start amount of molecule" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" formula="EPX-QNxBZE2pcwiBNY6NfA" isDefault="1" displayUnit="µmol">
+                            <Info flag="54" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="IU4huWwcnk2NTCHPaUIMAQ" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="_5AQF4X5mkuTWnIB24ghvw" isDefault="1" displayUnit="µmol/l">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Parameter id="CyiuKqVXgkecXnrdzASu8Q" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="58bkq_yv60yl49lQaCcEhQ" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                          </Parameter>
+                          <Parameter id="oxdXJYOoUEiOHFbUMu0cxw" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="NpiN9AC9ukSiunn3sXI3FQ" isDefault="1" displayUnit="min">
+                            <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Observer id="r6783LRLu0yWSEGN9d1j6w" name="Concentration in container" description="Concentration of the molecule" icon="Observer" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Enzyme, Observer" negativeValuesAllowed="1" formula="6wCmGaSt3UirOnRpXv6unA" displayUnit="µmol/l" />
+                        </Children>
+                      </MoleculeAmount>
+                      <MoleculeAmount id="gVpumttaHUG12bviSHchzw" name="Aciclovir" icon="DRUG" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" negativeValuesAllowed="0" mode="Logical" scaleDivisor="1" value="0" displayUnit="µmol">
+                        <Children>
+                          <Parameter id="QFG3ou7xRU-VRv69JiE0cw" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="_5AQF4X5mkuTWnIB24ghvw" isDefault="1" displayUnit="µmol/l">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Parameter id="gMp9ZynwlUyMDyk7t9nadQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="GZFxE_8Ry0Ca48OBeAzyUw" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                          </Parameter>
+                          <Observer id="92Mg0sSLa0CTnvtmJ_NiVw" name="Concentration in container" description="Concentration of the molecule" icon="Observer" persistable="1" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" negativeValuesAllowed="1" formula="6wCmGaSt3UirOnRpXv6unA" displayUnit="µmol/l" />
+                        </Children>
+                      </MoleculeAmount>
+                    </Children>
+                  </Container>
+                  <Container id="YTR4Ju2erUidh3ge7byGiA" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Observer id="yerBS3O790SeB9e7_npDFQ" name="Whole Blood" description="Whole Blood" icon="Observer" persistable="1" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" negativeValuesAllowed="1" formula="7iGibQcgYUuLrwW6654a_Q" displayUnit="µmol/l" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Container>
+              <Container id="hgXI4eBVj0ygpvBOivBZaA" name="Bone" description="Bone" icon="Bone" mode="Logical" containerType="Organ">
+                <Tags>
+                  <Tag value="TissueOrgan" />
+                </Tags>
+                <Children>
+                  <Parameter id="Ej_ICwEybkmzqIGUfQbLCA" name="Weight (tissue)" description="Weight of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="fliUWazsPUiRy_qjzM6EaA" isDefault="1" displayUnit="kg">
+                    <Tags>
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+                    </Tags>
+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
+                  </Parameter>
+                  <Parameter id="EGY_Bg6zO0m7_ty-hLg1jA" name="Blood flow rate" description="Organ blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="y6LwIbRu9ku8erXKf1RN9w" isDefault="1" displayUnit="l/min">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="48" source="Other" description="Absolute value = specific value (i.e. value normalized to the volume of the organ) multiplied by the organ volume" />
+                    <Info min="0" flag="62" seq="2" ref="0" bb="32" group="5" />
+                  </Parameter>
+                  <Parameter id="_h7omUHvkUOJb3H4b-vvsg" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="SEONXx9l8UekWRlG-vCS6A" isDefault="1" displayUnit="l/min">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="5" ref="0" bb="32" group="27" />
+                  </Parameter>
+                  <Parameter id="FzmTI08lkE641KSdTiulPg" name="Lymph flow rate" description="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="AHUOFh7VvEGdn9pbFbN0Ng" isDefault="1" displayUnit="l/min">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
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+                    <Info min="0" flag="122" seq="5" ref="0" bb="32" group="58" />
+                  </Parameter>
+                  <Parameter id="K4iJe-B7aUqi4UxBc5xc2g" name="Volume (endothelium)" description="Volume of  vascular endothelium" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="qwvyoVANaE6qdKtRf-uqjA" isDefault="1" displayUnit="l">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="62" seq="5" ref="0" bb="32" group="127" />
+                  </Parameter>
+                  <Parameter id="tHzin-eYkUunNvmOGHtmdA" name="Fraction intracellular" description="Fraction of intracellular space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="I-HZynBcWEaZVIcFkF3iMQ" isDefault="1">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
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+                    <Info min="0" max="1" flag="62" seq="16" ref="0" bb="32" group="64" />
+                  </Parameter>
+                  <Parameter id="6BND7vDK6Eetal8L7jSqCg" name="Density (tissue)" description="Density of tissue" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="38" seq="1" ref="0" bb="32" group="21" />
+                  </Parameter>
+                  <Parameter id="K_rvYY14XEGf5jpSpuxTgg" name="Fluid recirculation flow proportionality factor" description="proportionality factor linking fluid recirculation flow to lymph flow via small pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.96">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="27" />
+                  </Parameter>
+                  <Parameter id="5H9PLXkiKk-HE2pM6DkIDA" name="Lymph flow proportionality factor" description="Proportionality factor linking lymph flow to plasma flow" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.000662">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="58" />
+                  </Parameter>
+                  <Parameter id="L2ZK7E-DC0SDxwwvMZAnfQ" name="Organ volume mouse" description="Organ volume mouse" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.00158" displayUnit="l">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="65" />
+                  </Parameter>
+                  <Parameter id="vsLpWwyK8kuAMcY7It5vCA" name="Peripheral blood flow fraction" description="Blood flow fraction in organ used for calculation of peripheral venous blood concentrations" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="46" source="Publication" description="Thiel C, Schneckener S, Krauss M, Ghallab A, Hofmann U, et al. A systematic evaluation of the use of physiologically based pharmacokinetic modeling for cross-species extrapolation. J Pharm Sci. 2015 Jan;104(1):191-206 https://doi.org/10.1002/jps.24214" />
+                    <Info min="0" max="1" flag="122" seq="1" ref="0" bb="32" group="74" />
+                  </Parameter>
+                  <Parameter id="Bs1aGULd80Ci-gvEJ-_AUA" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
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+                    <Info min="2" max="2" flag="54" seq="1" ref="0" bb="32" group="2" />
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+                  <Parameter id="6QNvlQsMYE6Ji8PAon7gYg" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
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+                    <Info min="0" max="1" flag="54" seq="1" ref="0" bb="32" group="94" />
+                  </Parameter>
+                  <Parameter id="2R-bQZnpb0aE_axjRPUxwA" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.05">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
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+                    <Info min="0" max="1" flag="122" seq="5" ref="0" bb="32" group="114" />
+                  </Parameter>
+                  <Parameter id="geCuclLyLU2L47xFWvlabg" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" icon="Parameter" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="9E-12" displayUnit="ml/min/N">
+                    <Tags>
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+                    <Info min="0" flag="122" seq="5" ref="0" bb="32" group="115" />
+                  </Parameter>
+                  <Parameter id="guDItWXE90SaGHUgGIRL6Q" name="Radius (large pores)" description="Large endothelial pores radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.5E-07" displayUnit="µm">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
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+                    <Info min="0" flag="122" seq="5" ref="0" bb="32" group="55" />
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+                  <Parameter id="A2S05o9FL0eQmlZHuCe9lA" name="Radius (small pores)" description="Small endothelial pores radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="4.5E-08" displayUnit="µm">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
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+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="5" ref="0" bb="32" group="99" />
+                  </Parameter>
+                  <Parameter id="36vSTcnlhkOYQgBJJ_Paaw" name="Fraction vascular" description="Fraction of vascular space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.034">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="40" source="Publication" description="Edginton, A.N., Schmitt, W. &amp; Willmann, S. Clin Pharmacokinet (2006) 45: 1013. https://doi.org/10.2165/00003088-200645100-00005" />
+                    <Info min="0" max="1" flag="62" seq="15" ref="0" bb="32" group="64" />
+                  </Parameter>
+                  <Parameter id="sIKo70A3WkOA_t-YQU28PA" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.268">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
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+                    <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
+                    <Info min="0" max="1" flag="122" seq="15" ref="0" bb="32" group="85" />
+                  </Parameter>
+                  <Parameter id="3cBK0Xziika_602Vay-dDA" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.074">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
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+                    <Info min="0" max="1" flag="122" seq="15" ref="0" bb="32" group="86" />
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+                  <Parameter id="x8-L94H_RECI_LhdcyYlzg" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0011">
+                    <Tags>
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+                    <Info min="0" max="1" flag="122" seq="16" ref="0" bb="32" group="86" />
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+                  <Parameter id="-j2RG2-grk6WKraq-lfGJQ" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.268">
+                    <Tags>
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+                    <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
+                    <Info min="0" max="1" flag="122" seq="16" ref="0" bb="32" group="85" />
+                  </Parameter>
+                  <Parameter id="SlwpmxOTFE2CpdvCYz68-g" name="Fraction interstitial" description="Fraction of interstitial space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.1">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="19" source="Publication" description="Kawai R, Lemaire M, Steimer JL, Bruelisauer A, Niederberger W, Rowland M. Physiologically based pharmacokinetic study on a cyclosporin derivative, SDZ IMM 125. J Pharmacokinet Biopharm. 1994 Oct;22(5):327-65." />
+                    <Info min="0" max="1" flag="62" seq="17" ref="0" bb="32" group="64" />
+                  </Parameter>
+                  <Parameter id="rOh1-52nU0uGPTd28-xmQw" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.1">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="22" source="Publication" description="Rodgers T, Rowland M. Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J Pharm Sci. 2006 Jun;95(6):1238-57 https://doi.org/10.1002/jps.20502" />
+                    <Info min="0" max="1" flag="122" seq="17" ref="0" bb="32" group="111" />
+                  </Parameter>
+                  <Parameter id="ZzVf6BzlyE6iltcLa13YZA" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="24" source="Publication" description="POULIN P, THEIL F. Prediction of Pharmacokinetics Prior to In Vivo Studies. 1. Mechanism-Based Prediction of Volume of Distribution. JOURNAL OF PHARMACEUTICAL SCIENCES, VOL. 91, NO. 1, JANUARY 2002" />
+                    <Info min="0" max="1" flag="122" seq="17" ref="0" bb="32" group="112" />
+                  </Parameter>
+                  <Parameter id="PDhMeBxJU06B00HMgVeu7Q" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.05">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
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+                      <Tag value="TissueOrgan" />
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+                  <Parameter id="kk0qqqquO0incwoVBoaY6A" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.439">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
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+                    <Info min="0" max="1" flag="122" seq="17" ref="0" bb="32" group="86" />
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+                  <Parameter id="dAnT3C72sEWgsVE9asABLQ" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0174">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
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+                    <Info min="0" max="1" flag="122" seq="25" ref="0" bb="32" group="92" />
+                  </Parameter>
+                  <Parameter id="3XfD7LGGoUu0xkWjAOGcXw" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.017">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
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+                    <Info min="0" max="1" flag="122" seq="25" ref="0" bb="32" group="95" />
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+                  <Parameter id="yMdJfpESIEC6DcMEJSZcGg" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0016">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
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+                    <Info min="0" max="1" flag="122" seq="26" ref="0" bb="32" group="92" />
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+                  <Parameter id="57OKrvn2Zk23lqojDqXZCA" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0022">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
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+                  <Parameter id="yD1U2kN1-UK-gBKsns0UQA" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.1">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="21" source="Publication" description="Rodgers T, Leahy D, Rowland M. Physiologically based pharmacokinetic modeling 1: predicting the tissue distribution of moderate-to-strong bases. J Pharm Sci. 2005 Jun;94(6):1259-76. https://doi.org/10.1002/jps.20322" />
+                    <Info min="0" max="1" flag="122" seq="27" ref="0" bb="32" group="92" />
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+                  <Parameter id="T1Hh9RBng0qKpK7s9BSdlw" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.21">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
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+                    <Info min="0" max="1" flag="122" seq="27" ref="0" bb="32" group="95" />
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+                  <Parameter id="iKvEv5RA8kWK-SYUeK8X3g" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.317">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
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+                    <ValueOrigin id="22" source="Publication" description="Rodgers T, Rowland M. Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J Pharm Sci. 2006 Jun;95(6):1238-57 https://doi.org/10.1002/jps.20502" />
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+                  <Parameter id="8njaOkX8lkiv_4LH9a4oBg" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.26">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="28" ref="0" bb="32" group="95" />
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+                  <Parameter id="_vHfMUXKCE6qbPnhsZbCsg" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.67">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
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+                    <ValueOrigin id="21" source="Publication" description="Rodgers T, Leahy D, Rowland M. Physiologically based pharmacokinetic modeling 1: predicting the tissue distribution of moderate-to-strong bases. J Pharm Sci. 2005 Jun;94(6):1259-76. https://doi.org/10.1002/jps.20322" />
+                    <Info min="0" max="1000" flag="122" seq="29" ref="0" bb="32" group="92" />
+                  </Parameter>
+                  <Parameter id="-CNcXakh8EyzVZscr60kCg" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0008">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="29" ref="0" bb="32" group="95" />
+                  </Parameter>
+                  <DistributedParameter id="Y5GLMA8zdkqySX_U0HNUgg" name="Specific blood flow rate" description="Blood flow rate normalized to the organ volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" formula="oEa48DKoWUCRR0hJ2uaZFQ" mode="Logical" isDefault="1" displayUnit="ml/min/100g organ">
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+                      <Parameter id="nhve6pPCeUmjz-BWrXcY6A" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="5" />
+                      </Parameter>
+                      <Parameter id="eBamx0HMLkOenBJCRjbU6Q" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.027495" displayUnit="ml/min/100g organ">
+                        <Info min="0" flag="50" seq="1" ref="0" bb="32" group="5" />
+                      </Parameter>
+                      <Parameter id="A1A9tOa-j0m5vbEnJsGeFQ" name="Deviation" description="Standard deviation of Normal distribution" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.00137475" displayUnit="ml/min/100g organ">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="5" />
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+                      <Container id="qilYIhQIhk69XukCfBmW-Q" name="Aciclovir" mode="Logical" containerType="Molecule" />
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+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="40" source="Publication" description="Edginton, A.N., Schmitt, W. &amp; Willmann, S. Clin Pharmacokinet (2006) 45: 1013. https://doi.org/10.2165/00003088-200645100-00005" />
+                    <Info min="0" flag="122" seq="1" ref="0" bb="32" group="5" />
+                  </DistributedParameter>
+                  <DistributedParameter id="YfwbdVVjW0-IC_5kkl15Xg" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="hqQKDg3QKkeUoi3k52PUXA" mode="Logical" isDefault="1" displayUnit="l">
+                    <Children>
+                      <Parameter id="HU2nSFxY_EO2kiQc58mOdw" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.503195778884588">
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+                      </Parameter>
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+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="65" />
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+                      <Tag value="TissueOrgan" />
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+                    <Info min="0" flag="106" seq="2" ref="0" bb="32" group="65" />
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+                    <Tags>
+                      <Tag value="Bone" />
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+                      <Parameter id="GkrQw0TOaEOGbjfw5Cw0-A" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="WiDWMA7xi02WdVvl1Rjr0g" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
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+                        <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
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+                      <MoleculeAmount id="kOF7ojFNCUC6MBAwCWFyPQ" name="CYP344" icon="ENZYME" persistable="0" isFixedValue="0" dim="Amount" quantityType="Enzyme" negativeValuesAllowed="0" formula="rMXLZglcaUaofPZ0c6I6Yw" mode="Logical" scaleDivisor="1" displayUnit="µmol">
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+                          <Parameter id="CSxUgt7-l06J0GAUN7CisA" name="Degradation coefficient" description="First order turnover rate constant of the enzyme" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="c2fNMePAyki4XPdR-AEHaQ" isDefault="1" displayUnit="1/min">
+                            <ValueOrigin id="33" source="Other" description="OSP Suite Manual Chapter 16. PK-Sim®- Compounds: Defining inhibition/induction processes" />
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="91" />
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+                          <Parameter id="RJF7KwnXg02U9rIJNe9hDA" name="Relative expression" description="Relative expression" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="fqrxyq94VkWMTLJeRjjhEQ" isDefault="1">
+                            <Info min="0" flag="60" seq="1" ref="0" bb="2" group="91" />
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+                          <Parameter id="xXiCZFNl8UmAkurkySIuWg" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="YQ_SIzoIak2o9B3xCbLazA" isDefault="1">
+                            <Info min="0" flag="58" seq="1" ref="0" bb="2" group="91" />
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+                          <Parameter id="ziLGpB2uQkuzN2mYwfSZdA" name="Relative expression out." description="Relative Expression that will be used in the simulation" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="fbRCNZOks0i0JlaOaYnbvg" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="91" />
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+                          <Parameter id="mefP1rwg9E-h2zIa6lpfKw" name="Start amount" description="Start amount of molecule" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" formula="EPX-QNxBZE2pcwiBNY6NfA" isDefault="1" displayUnit="µmol">
+                            <Info flag="54" seq="1" ref="0" bb="2" group="91" />
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+                          <Parameter id="TY26A2r78Eur0X3Z8B3bWQ" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="_5AQF4X5mkuTWnIB24ghvw" isDefault="1" displayUnit="µmol/l">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="2" group="117" />
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+                          <Parameter id="elPG_ETBrUe1bNw5wIdcFw" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="7ASkZ3qPvU-NoH8dS-e-Fg" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
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+                          <Parameter id="Trb1nAvcZUuv9pQ0R6hGmg" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="4wxQtjbNW0mRERBdQVCzvg" isDefault="1" displayUnit="min">
+                            <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
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+                          <Observer id="rbUVGoFMQkG0Qbao5h-Ukw" name="Concentration in container" description="Concentration of the molecule" icon="Observer" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Enzyme, Observer" negativeValuesAllowed="1" formula="6wCmGaSt3UirOnRpXv6unA" displayUnit="µmol/l" />
+                        </Children>
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+                      <MoleculeAmount id="TGkDx4tZT0ypmP-gEA4AuA" name="Aciclovir" icon="DRUG" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" negativeValuesAllowed="0" mode="Logical" scaleDivisor="1" value="0" displayUnit="µmol">
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+                            <Info min="0" flag="18" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Parameter id="n4fN3OB4jUWCEAMifgXXQw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="PI68lIvecE-qAkep6hyuQA" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                          </Parameter>
+                          <Observer id="AQk8HhAeb0uau8bzClbsmQ" name="Concentration in container" description="Concentration of the molecule" icon="Observer" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" negativeValuesAllowed="1" formula="6wCmGaSt3UirOnRpXv6unA" displayUnit="µmol/l" />
+                        </Children>
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+                    <Tags>
+                      <Tag value="Bone" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="SYrL9JYx5EWduW8tQ4mHwQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="WiDWMA7xi02WdVvl1Rjr0g" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
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+                      <Parameter id="cq4PWLgJk0mbmvQYKXGB_A" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="H_SN9-_mbUGRPDaFmFf1dQ" isDefault="1" displayUnit="l">
+                        <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
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+                        <Children>
+                          <Parameter id="TXJKC3Rs8kqtUWZ02-E0AQ" name="Degradation coefficient" description="First order turnover rate constant of the enzyme" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="c2fNMePAyki4XPdR-AEHaQ" isDefault="1" displayUnit="1/min">
+                            <ValueOrigin id="33" source="Other" description="OSP Suite Manual Chapter 16. PK-Sim®- Compounds: Defining inhibition/induction processes" />
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+                          <Parameter id="7yOBXskHpEqgdJugi9qg-Q" name="Relative expression" description="Relative expression" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="cLw6IJb0kk-aHdh1YkXHkw" isDefault="1">
+                            <Info min="0" flag="60" seq="1" ref="0" bb="2" group="91" />
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+                          <Parameter id="jhTJYp3I-0-n09LaaeE4zg" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="xTktpLRZC0e7-rlZenlyLg" isDefault="1">
+                            <Info min="0" flag="58" seq="1" ref="0" bb="2" group="91" />
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+                          <Parameter id="PyoL-544-kWT7TgSsDIGeQ" name="Relative expression out." description="Relative Expression that will be used in the simulation" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="fbRCNZOks0i0JlaOaYnbvg" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="91" />
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+                            <Info flag="54" seq="1" ref="0" bb="2" group="91" />
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+                          <Parameter id="1q4hegvIYE6aer5ZUR-dTw" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="_5AQF4X5mkuTWnIB24ghvw" isDefault="1" displayUnit="µmol/l">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="2" group="117" />
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+                          <Parameter id="90PS3fk4UEKIDuSTy7frdQ" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="d6gu5LcrNEOmeMPHqG7ZoA" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
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+                          <Parameter id="7SFni4Jb-kGI6na-Gbj-Qg" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="-2YlUk46oUe9dsHRXPM0rQ" isDefault="1" displayUnit="min">
+                            <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Observer id="b-d_JH2d8EOS6M_GxVS7-Q" name="Concentration in container" description="Concentration of the molecule" icon="Observer" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Enzyme, Observer" negativeValuesAllowed="1" formula="6wCmGaSt3UirOnRpXv6unA" displayUnit="µmol/l" />
+                        </Children>
+                      </MoleculeAmount>
+                      <MoleculeAmount id="0bzVR1eNmUGmMRhYoqacIA" name="Aciclovir" icon="DRUG" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" negativeValuesAllowed="0" mode="Logical" scaleDivisor="1" value="0" displayUnit="µmol">
+                        <Children>
+                          <Parameter id="qV2mM-DYrkuZJ3ro9okKDw" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="_5AQF4X5mkuTWnIB24ghvw" isDefault="1" displayUnit="µmol/l">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Parameter id="_0QPIgXrhkiV_-AMzt_XDg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="YNL9XgCy4EuY41nQg3w7rA" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                          </Parameter>
+                          <Observer id="MhmQVTw9a0ysuEx5MgLaCg" name="Concentration in container" description="Concentration of the molecule" icon="Observer" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" negativeValuesAllowed="1" formula="6wCmGaSt3UirOnRpXv6unA" displayUnit="µmol/l" />
+                        </Children>
+                      </MoleculeAmount>
+                    </Children>
+                  </Container>
+                  <Container id="QBUx9bH5y06GCUzGSeKCLw" name="Interstitial" description="Interstitial" icon="Interstitial" mode="Physical" containerType="Compartment">
+                    <Tags>
+                      <Tag value="Bone" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="XB5qWfvX1UGSbUX_eCyB5A" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="WiDWMA7xi02WdVvl1Rjr0g" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="p8kGQosEhUmGnVZ2eSVrfQ" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="9uWm2G1z9EK-p6oBMLbcVA" isDefault="1" displayUnit="l">
+                        <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                        <Info min="0" flag="62" seq="5" ref="0" bb="2" group="124" />
+                      </Parameter>
+                      <Parameter id="ebmXoNwVqkCnBQBsy0Gthg" name="pH" description="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="eK4DKfgMbEONwPdNpejUig" isDefault="1">
+                        <Tags>
+                          <Tag value="Bone" />
+                        </Tags>
+                        <Info min="0" max="14" flag="122" seq="17" ref="0" bb="32" group="84" />
+                      </Parameter>
+                      <MoleculeAmount id="kpPnx5In4Em3nHuoD25U8g" name="Aciclovir" icon="DRUG" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" negativeValuesAllowed="0" mode="Logical" scaleDivisor="1" value="0" displayUnit="µmol">
+                        <Children>
+                          <Parameter id="UCmILoibPEeKd4VGXl5Cig" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="_5AQF4X5mkuTWnIB24ghvw" isDefault="1" displayUnit="µmol/l">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Parameter id="dQOREddPn0q-fSKNsLS_5Q" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="MaePxqI82U6Zu9P5SP30Jw" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                          </Parameter>
+                          <Observer id="_lOc7PWC60OicEmzC5zauA" name="Concentration in container" description="Concentration of the molecule" icon="Observer" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" negativeValuesAllowed="1" formula="6wCmGaSt3UirOnRpXv6unA" displayUnit="µmol/l" />
+                        </Children>
+                      </MoleculeAmount>
+                    </Children>
+                  </Container>
+                  <Container id="hs6hGJmloUeaW8ZS5ktyrw" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
+                    <Tags>
+                      <Tag value="Bone" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="FQpTQo2-rUydorg7EqwwAA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="J_zsXA_hVEGtRM46zqPvJg" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="7coWJ0JkekuQKz-jjFZ8Fw" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="GXZJgB5-lEOADgF16J9WjQ" isDefault="1" displayUnit="l">
+                        <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                        <Info min="0" flag="62" seq="5" ref="0" bb="2" group="125" />
+                      </Parameter>
+                      <Parameter id="BYRsEwEm506iW2AFaAB1WQ" name="pH" description="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7">
+                        <Tags>
+                          <Tag value="Bone" />
+                        </Tags>
+                        <ValueOrigin id="34" source="Publication" description="Toxicol In Vitro. 2008 Mar;22(2):457-67 https://doi.org/10.1016/j.tiv.2007.09.010" />
+                        <Info min="0" max="14" flag="122" seq="17" ref="0" bb="32" group="83" />
+                      </Parameter>
+                      <MoleculeAmount id="o8gRQNpO2k65BVtXDk79eQ" name="CYP344" icon="ENZYME" persistable="0" isFixedValue="0" dim="Amount" quantityType="Enzyme" negativeValuesAllowed="0" formula="rMXLZglcaUaofPZ0c6I6Yw" mode="Logical" scaleDivisor="1" displayUnit="µmol">
+                        <Children>
+                          <Parameter id="uXLAzHU8l0GCoO7u5sBAdg" name="Degradation coefficient" description="First order turnover rate constant of the enzyme" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="c2fNMePAyki4XPdR-AEHaQ" isDefault="1" displayUnit="1/min">
+                            <ValueOrigin id="33" source="Other" description="OSP Suite Manual Chapter 16. PK-Sim®- Compounds: Defining inhibition/induction processes" />
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="0f_HTZU0F0-JoKye6Ut17g" name="Relative expression" description="Relative expression" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0">
+                            <Info min="0" flag="60" seq="1" ref="0" bb="32" group="91" />
+                          </Parameter>
+                          <Parameter id="yOrOzaoMt0OAhi1mDD3ipQ" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0">
+                            <Info min="0" flag="58" seq="1" ref="0" bb="32" group="91" />
+                          </Parameter>
+                          <Parameter id="NdkgOUxwmk-cA49VF07Yow" name="Relative expression out." description="Relative Expression that will be used in the simulation" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="fbRCNZOks0i0JlaOaYnbvg" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="GFRfHLrvYkO6zjncGMq_8g" name="Start amount" description="Start amount of molecule" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" formula="EPX-QNxBZE2pcwiBNY6NfA" isDefault="1" displayUnit="µmol">
+                            <Info flag="54" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="ychKdoSce0mc3iFV--s3mw" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="_5AQF4X5mkuTWnIB24ghvw" isDefault="1" displayUnit="µmol/l">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Parameter id="_CfrLyPQ5UaNgfi6uXXrcg" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Z9NDl48aAkugA4yPR9-guQ" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                          </Parameter>
+                          <Parameter id="7kfMTFqX5UGud_y1ILZ7DA" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="1v96gX7HykuauuV20QFtKg" isDefault="1" displayUnit="min">
+                            <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Observer id="Qjl4wYsgXUujHIYSOSGjdQ" name="Concentration in container" description="Concentration of the molecule" icon="Observer" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Enzyme, Observer" negativeValuesAllowed="1" formula="6wCmGaSt3UirOnRpXv6unA" displayUnit="µmol/l" />
+                        </Children>
+                      </MoleculeAmount>
+                      <MoleculeAmount id="AFhrjVdoiECTbQgiVV716A" name="Aciclovir" icon="DRUG" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" negativeValuesAllowed="0" mode="Logical" scaleDivisor="1" value="0" displayUnit="µmol">
+                        <Children>
+                          <Parameter id="rJJQVQYk1UK4TNN98c48Gg" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="_5AQF4X5mkuTWnIB24ghvw" isDefault="1" displayUnit="µmol/l">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Parameter id="J9WqseJmlEigcLD8RAz6GA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="MXRrMyJvWE2yqyptj2A6sQ" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                          </Parameter>
+                          <Observer id="OYb9j2s-lk6iGpUpz97lYw" name="Concentration in container" description="Concentration of the molecule" icon="Observer" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" negativeValuesAllowed="1" formula="6wCmGaSt3UirOnRpXv6unA" displayUnit="µmol/l" />
+                        </Children>
+                      </MoleculeAmount>
+                    </Children>
+                  </Container>
+                  <Container id="J4TZT7WbHkee2bpm4B439w" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Observer id="uTVshjQMykWjBJy_eqPIDw" name="Interstitial Unbound" description="Interstitial Unbound" icon="Observer" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" negativeValuesAllowed="1" formula="9puGFowK4EWaB_uKiCUkZg" displayUnit="µmol/l" />
+                      <Observer id="L5AMJ44MtU-Z10M9YnWLPg" name="Intracellular Unbound" description="Intracellular Unbound" icon="Observer" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" negativeValuesAllowed="1" formula="teOQNDXPokGxR8_kXybQ_A" displayUnit="µmol/l" />
+                      <Observer id="wn1SVy638E2cvUXmiP6aaA" name="Tissue" description="Tissue" icon="Observer" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" negativeValuesAllowed="1" formula="vXvnx5OPgEOFlJ6Oq1kSGw" displayUnit="µmol/l" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Container>
+              <Container id="0yTaY2gd3UipyrhEBeHPwQ" name="Gallbladder" description="Bile compartment used to collect excretion to the bile" icon="Gallbladder" mode="Physical" containerType="Organ">
+                <Tags>
+                  <Tag value="Liver" />
+                </Tags>
+                <Children>
+                  <Parameter id="C9cLR3Hj6EqSZvL3iWAJFw" name="Time to complete gallbladder refilling" description="Time to complete gallbladder refilling" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="15m_WCg6Z0KK6wvrHWe46w" isDefault="1" displayUnit="min">
+                    <Info min="0" flag="122" seq="3" ref="0" bb="2" group="128" />
+                  </Parameter>
+                  <Parameter id="Gf3swpn-lEKsaJ7M9AqLVw" name="Gallbladder emptying active" description="Gallbladder emptying active" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0">
+                    <Info min="0" max="1" flag="52" seq="4" ref="0" bb="2" group="128" />
+                  </Parameter>
+                  <Parameter id="Es2O4ivRLkG51Y-MNV-x3g" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="l">
+                    <Info min="0" flag="38" seq="666" ref="0" bb="2" group="65" />
+                  </Parameter>
+                  <Parameter id="_oYa1y52CUuTx7sQ-pJMjA" name="Gallbladder ejection half-time" description="Half time for gallbladder emptying (exponential release)" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="19.7" displayUnit="min">
+                    <Tags>
+                      <Tag value="Liver" />
+                    </Tags>
+                    <Info min="0" flag="122" seq="1" ref="0" bb="32" group="128" />
+                  </Parameter>
+                  <Parameter id="hWT6Q30urEuSyCwhJEAj8A" name="Gallbladder ejection fraction" description="Fraction of liquid volume discretely ejected into the duodenum. The total liquid volume available in the gallbladder depends on the time after last gallbladder emptying and the parameter &quot;Time to complete gallbladder refilling&quot;" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.65">
+                    <Tags>
+                      <Tag value="Liver" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="2" ref="0" bb="32" group="128" />
+                  </Parameter>
+                  <MoleculeAmount id="bvwNErPs6U2pactFp6kebQ" name="Aciclovir" icon="DRUG" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" negativeValuesAllowed="0" mode="Logical" scaleDivisor="1" value="0" displayUnit="µmol">
+                    <Children>
+                      <Parameter id="AZn1VGa8F0WaTLSqPNaZYQ" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="_5AQF4X5mkuTWnIB24ghvw" isDefault="1" displayUnit="µmol/l">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Observer id="EYn7gzXRdUq0QWvi_UOdvw" name="Fraction excreted to bile" icon="Observer" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Drug, Observer" negativeValuesAllowed="1" formula="64G-qYh7HkOKmLxKkMl0fA" />
+                    </Children>
+                  </MoleculeAmount>
+                </Children>
+              </Container>
+              <Container id="PL7HMPB8zkeFkFXx77eicQ" name="Brain" description="Brain" icon="Brain" mode="Logical" containerType="Organ">
+                <Tags>
+                  <Tag value="TissueOrgan" />
+                </Tags>
+                <Children>
+                  <Parameter id="P9hy31DOjkGtUBFknS6XZw" name="Weight (tissue)" description="Weight of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="fliUWazsPUiRy_qjzM6EaA" isDefault="1" displayUnit="kg">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
+                  </Parameter>
+                  <Parameter id="a_gyW0u-z0ynQBmItBeN0g" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="SEONXx9l8UekWRlG-vCS6A" isDefault="1" displayUnit="l/min">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="6" ref="0" bb="32" group="27" />
+                  </Parameter>
+                  <Parameter id="zRN90XM6pka1fuRlX4PBOQ" name="Lymph flow rate" description="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="AHUOFh7VvEGdn9pbFbN0Ng" isDefault="1" displayUnit="l/min">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="6" ref="0" bb="32" group="58" />
+                  </Parameter>
+                  <Parameter id="8iIzT98Lr06pcoI2KYZfMA" name="Volume (endothelium)" description="Volume of  vascular endothelium" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="S7A_IthbV0i4gX0pNAuUSQ" isDefault="1" displayUnit="l">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="62" seq="6" ref="0" bb="32" group="127" />
+                  </Parameter>
+                  <Parameter id="l2JwSmiEOEWUho4ilRb_rg" name="Fraction intracellular" description="Fraction of intracellular space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="I-HZynBcWEaZVIcFkF3iMQ" isDefault="1">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="62" seq="19" ref="0" bb="32" group="64" />
+                  </Parameter>
+                  <Parameter id="nDdXUTMxaUWFOMa1g3ijpg" name="Blood flow rate" description="Organ blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="y6LwIbRu9ku8erXKf1RN9w" isDefault="1" displayUnit="l/min">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="48" source="Other" description="Absolute value = specific value (i.e. value normalized to the volume of the organ) multiplied by the organ volume" />
+                    <Info min="0" flag="62" seq="22" ref="0" bb="32" group="5" />
+                  </Parameter>
+                  <Parameter id="dwQueICsl02xGnCMH2qS_g" name="Density (tissue)" description="Density of tissue" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="38" seq="1" ref="0" bb="32" group="21" />
+                  </Parameter>
+                  <Parameter id="QUhWCrVbMk64pgUUNOw5ug" name="Fluid recirculation flow proportionality factor" description="proportionality factor linking fluid recirculation flow to lymph flow via small pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.404">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="27" />
+                  </Parameter>
+                  <Parameter id="z9acep-IRUuMXochZb5asA" name="Lymph flow proportionality factor" description="Proportionality factor linking lymph flow to plasma flow" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.27E-05">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="58" />
+                  </Parameter>
+                  <Parameter id="wgHLJEYO202d0z6W5g1Rtg" name="Organ volume mouse" description="Organ volume mouse" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.00017" displayUnit="l">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="65" />
+                  </Parameter>
+                  <Parameter id="IkHJmWLl1k-PwcGvPcV8zw" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="0" flag="54" seq="1" ref="0" bb="32" group="2" />
+                  </Parameter>
+                  <Parameter id="HJbtJad0-kKVhrii8XAZTA" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="54" seq="1" ref="0" bb="32" group="94" />
+                  </Parameter>
+                  <Parameter id="QW2mVe03QUmRNusvDTQW2w" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.05">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
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+                    <Info min="0" max="1" flag="122" seq="6" ref="0" bb="32" group="114" />
+                  </Parameter>
+                  <Parameter id="qBDy-sCM60GvsxvCuGvKmA" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" icon="Parameter" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="5E-14" displayUnit="ml/min/N">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
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+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="6" ref="0" bb="32" group="115" />
+                  </Parameter>
+                  <Parameter id="5dKwuf39qEiraae_7aA24A" name="Radius (large pores)" description="Large endothelial pores radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.5E-07" displayUnit="µm">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
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+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="6" ref="0" bb="32" group="55" />
+                  </Parameter>
+                  <Parameter id="tm_Vh8YFVU-Y2Xr1shpHUQ" name="Radius (small pores)" description="Small endothelial pores radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="4.5E-08" displayUnit="µm">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="6" ref="0" bb="32" group="99" />
+                  </Parameter>
+                  <Parameter id="fXz5oz4ru0GFB_5qKdF5Tw" name="Fraction vascular" description="Fraction of vascular space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.039">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="40" source="Publication" description="Edginton, A.N., Schmitt, W. &amp; Willmann, S. Clin Pharmacokinet (2006) 45: 1013. https://doi.org/10.2165/00003088-200645100-00005" />
+                    <Info min="0" max="1" flag="62" seq="18" ref="0" bb="32" group="64" />
+                  </Parameter>
+                  <Parameter id="-d5kKbaoPUqDaydyr6H5ZA" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.11">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
+                    <Info min="0" max="1" flag="122" seq="18" ref="0" bb="32" group="85" />
+                  </Parameter>
+                  <Parameter id="kOsmctx0QUuDJ4asvnw-CA" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.051">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="18" ref="0" bb="32" group="86" />
+                  </Parameter>
+                  <Parameter id="l2mYBeV1s06TtCbt9IatKA" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0565">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
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+                    <Info min="0" max="1" flag="122" seq="19" ref="0" bb="32" group="86" />
+                  </Parameter>
+                  <Parameter id="K3ZLmng41km2mcLGI0LaxQ" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.081">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
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+                    <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
+                    <Info min="0" max="1" flag="122" seq="19" ref="0" bb="32" group="85" />
+                  </Parameter>
+                  <Parameter id="P9CEKPN6IkyQIeJFG0DGAw" name="Fraction interstitial" description="Fraction of interstitial space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.004">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="19" source="Publication" description="Kawai R, Lemaire M, Steimer JL, Bruelisauer A, Niederberger W, Rowland M. Physiologically based pharmacokinetic study on a cyclosporin derivative, SDZ IMM 125. J Pharmacokinet Biopharm. 1994 Oct;22(5):327-65." />
+                    <Info min="0" max="1" flag="62" seq="20" ref="0" bb="32" group="64" />
+                  </Parameter>
+                  <Parameter id="0QqPVM7_mke25RGTVw4A7Q" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.048">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="22" source="Publication" description="Rodgers T, Rowland M. Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J Pharm Sci. 2006 Jun;95(6):1238-57 https://doi.org/10.1002/jps.20502" />
+                    <Info min="0" max="1" flag="122" seq="20" ref="0" bb="32" group="111" />
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+                  <Parameter id="rjqwUVmJk0SH_0K1Fd2GnA" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
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+                    <ValueOrigin id="24" source="Publication" description="POULIN P, THEIL F. Prediction of Pharmacokinetics Prior to In Vivo Studies. 1. Mechanism-Based Prediction of Volume of Distribution. JOURNAL OF PHARMACEUTICAL SCIENCES, VOL. 91, NO. 1, JANUARY 2002" />
+                    <Info min="0" max="1" flag="122" seq="20" ref="0" bb="32" group="112" />
+                  </Parameter>
+                  <Parameter id="tGe-7ixKvEKVsy6tM3UGtw" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.041">
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+                    <Info min="0" max="1" flag="122" seq="20" ref="0" bb="32" group="113" />
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+                    <Tags>
+                      <Tag value="TissueOrgan" />
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+                    <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
+                    <Info min="0" max="1" flag="122" seq="20" ref="0" bb="32" group="85" />
+                  </Parameter>
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+                    <Tags>
+                      <Tag value="TissueOrgan" />
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+                    <Info min="0" max="1" flag="122" seq="20" ref="0" bb="32" group="86" />
+                  </Parameter>
+                  <Parameter id="9SuwJSDThUimZ8BZoEF18w" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0391">
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+                    <Info min="0" max="1" flag="122" seq="30" ref="0" bb="32" group="92" />
+                  </Parameter>
+                  <Parameter id="irwZNN-TZEOjC0UgqhaqrQ" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0429">
+                    <Tags>
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+                    <Info min="0" max="1" flag="122" seq="30" ref="0" bb="32" group="95" />
+                  </Parameter>
+                  <Parameter id="pg3RPEkCuE2q-WgKwAQ0rQ" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0015">
+                    <Tags>
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+                    <Info min="0" max="1" flag="122" seq="31" ref="0" bb="32" group="92" />
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+                    <Tags>
+                      <Tag value="TissueOrgan" />
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+                    <Info min="0" max="1" flag="122" seq="31" ref="0" bb="32" group="95" />
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+                  <Parameter id="l5Zo7xeSJkyHO2NF4rgfXA" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.162">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
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+                    <ValueOrigin id="21" source="Publication" description="Rodgers T, Leahy D, Rowland M. Physiologically based pharmacokinetic modeling 1: predicting the tissue distribution of moderate-to-strong bases. J Pharm Sci. 2005 Jun;94(6):1259-76. https://doi.org/10.1002/jps.20322" />
+                    <Info min="0" max="1" flag="122" seq="32" ref="0" bb="32" group="92" />
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+                    <Info min="0" max="1" flag="122" seq="32" ref="0" bb="32" group="95" />
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+                  <Parameter id="xHg7n-Bkt0eizt_-lzNhng" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.591">
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+                    <Info min="0" max="1" flag="122" seq="33" ref="0" bb="32" group="92" />
+                  </Parameter>
+                  <Parameter id="r4YKRTBpc0uYpKs3H-Oo0w" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.79">
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+                      <Tag value="TissueOrgan" />
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+                    <Info min="0" max="1" flag="122" seq="33" ref="0" bb="32" group="95" />
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+                  <Parameter id="c1oeaO6InUeV5JH7ncsWbA" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.4">
+                    <Tags>
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+                    <ValueOrigin id="21" source="Publication" description="Rodgers T, Leahy D, Rowland M. Physiologically based pharmacokinetic modeling 1: predicting the tissue distribution of moderate-to-strong bases. J Pharm Sci. 2005 Jun;94(6):1259-76. https://doi.org/10.1002/jps.20322" />
+                    <Info min="0" max="1000" flag="122" seq="34" ref="0" bb="32" group="92" />
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+                  <Parameter id="Xx439UgiAEeQnVDYlP2pRg" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0143">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
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+                    <Info min="0" max="1" flag="122" seq="34" ref="0" bb="32" group="95" />
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+                  <DistributedParameter id="nbONxRMFCkOvV_Xz8E0qHg" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="NnlpEi1ShUGVQZhB7adckw" mode="Logical" isDefault="1" displayUnit="l">
+                    <Children>
+                      <Parameter id="NEqDwzgn7kKIwrhR87pY0g" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.501756837097977">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="65" />
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+                      <Parameter id="CwXcF2v9wkelEDGo7WAFyw" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.5088" displayUnit="l">
+                        <Info min="0" flag="34" seq="1" ref="0" bb="32" group="65" />
+                      </Parameter>
+                      <Parameter id="p0bl20FMHU66adxMQ4Fhrw" name="Deviation" description="Standard deviation of Normal distribution" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.07544" displayUnit="l">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="65" />
+                      </Parameter>
+                      <Container id="kJMqEuCxj023pO6vxQJ2oQ" name="Aciclovir" mode="Logical" containerType="Molecule" />
+                    </Children>
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+                      <Tag value="TissueOrgan" />
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+                    <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
+                    <Info min="0" flag="106" seq="3" ref="0" bb="32" group="65" />
+                  </DistributedParameter>
+                  <DistributedParameter id="rralngxxuEy2gTYCsG7tfA" name="Specific blood flow rate" description="Blood flow rate normalized to the organ volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" formula="qFrodsl2AUKYGludflT-hQ" mode="Logical" isDefault="1" displayUnit="ml/min/100g organ">
+                    <Children>
+                      <Parameter id="BjX-r9OBsUeJnrKA0vAzyw" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="5" />
+                      </Parameter>
+                      <Parameter id="FZxY5yPWu068ofQ5e6zqmw" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.51675" displayUnit="ml/min/100g organ">
+                        <Info min="0" flag="50" seq="1" ref="0" bb="32" group="5" />
+                      </Parameter>
+                      <Parameter id="ee3rL0Tra06OCKNp83u7Sg" name="Deviation" description="Standard deviation of Normal distribution" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0258375" displayUnit="ml/min/100g organ">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="5" />
+                      </Parameter>
+                      <Container id="LdIwRHHL4UmlS1CrKjij_Q" name="Aciclovir" mode="Logical" containerType="Molecule" />
+                    </Children>
+                    <Tags>
+                      <Tag value="TissueOrgan" />
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+                    <ValueOrigin id="40" source="Publication" description="Edginton, A.N., Schmitt, W. &amp; Willmann, S. Clin Pharmacokinet (2006) 45: 1013. https://doi.org/10.2165/00003088-200645100-00005" />
+                    <Info min="0" flag="122" seq="21" ref="0" bb="32" group="5" />
+                  </DistributedParameter>
+                  <Container id="6o29eHLmlky4_L3eSRa9CQ" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
+                    <Tags>
+                      <Tag value="Brain" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="p22COHfyjEq-baE4hqQqRA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="WiDWMA7xi02WdVvl1Rjr0g" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="g9ZwKzmLQUCi2LMTtEPosA" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="yYX4DjDwkEOGUvd-DF06pA" isDefault="1" displayUnit="l">
+                        <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                        <Info min="0" flag="62" seq="6" ref="0" bb="2" group="126" />
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+                      <MoleculeAmount id="GhrMdLmqxUKm1nxdStCBzg" name="CYP344" icon="ENZYME" persistable="0" isFixedValue="0" dim="Amount" quantityType="Enzyme" negativeValuesAllowed="0" formula="rMXLZglcaUaofPZ0c6I6Yw" mode="Logical" scaleDivisor="1" displayUnit="µmol">
+                        <Children>
+                          <Parameter id="FLPI9KNFJkmq48GZXQil1g" name="Degradation coefficient" description="First order turnover rate constant of the enzyme" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="c2fNMePAyki4XPdR-AEHaQ" isDefault="1" displayUnit="1/min">
+                            <ValueOrigin id="33" source="Other" description="OSP Suite Manual Chapter 16. PK-Sim®- Compounds: Defining inhibition/induction processes" />
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="CCELgU1PFk-idKp9TAloHQ" name="Relative expression" description="Relative expression" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="fqrxyq94VkWMTLJeRjjhEQ" isDefault="1">
+                            <Info min="0" flag="60" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="OfW11LQVbEeb9Qb8SL4kqQ" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="YQ_SIzoIak2o9B3xCbLazA" isDefault="1">
+                            <Info min="0" flag="58" seq="1" ref="0" bb="2" group="91" />
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+                          <Parameter id="fieWV1S460S5wrGRjYFU9g" name="Relative expression out." description="Relative Expression that will be used in the simulation" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="fbRCNZOks0i0JlaOaYnbvg" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="91" />
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+                          <Parameter id="K-RLdVUTEEqonWc5BZo2jA" name="Start amount" description="Start amount of molecule" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" formula="EPX-QNxBZE2pcwiBNY6NfA" isDefault="1" displayUnit="µmol">
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+                      <Tag value="TissueOrgan" />
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+                    <Info min="0" flag="62" seq="7" ref="0" bb="32" group="127" />
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+                  <Parameter id="Wkt5jyCPj0SK-pN9CeALIA" name="Fraction intracellular" description="Fraction of intracellular space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="I-HZynBcWEaZVIcFkF3iMQ" isDefault="1">
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+                    <Info min="0" max="1" flag="62" seq="22" ref="0" bb="32" group="64" />
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+                    <Tags>
+                      <Tag value="TissueOrgan" />
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+                    <Info min="0" flag="38" seq="1" ref="0" bb="32" group="21" />
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+                    <Info min="0" max="1" flag="122" seq="22" ref="0" bb="32" group="85" />
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+                    <Tags>
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+                    <Info min="0" max="1" flag="122" seq="23" ref="0" bb="32" group="111" />
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+                        <Info min="0" max="1" flag="50" seq="1" ref="0" bb="32" group="86" />
+                      </Parameter>
+                      <Container id="Fosjmt3e-Eyqks6ju9_wew" name="Aciclovir" mode="Logical" containerType="Molecule" />
+                    </Children>
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="23" ref="0" bb="32" group="86" />
+                  </DistributedParameter>
+                  <DistributedParameter id="i6RsyXqSVkWo6m4Ia-3OLA" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="lbKSKKmv0E2klUS3KXoyeg" mode="Logical" isDefault="1">
+                    <Children>
+                      <Parameter id="MTWvLoWUskO743c5AvrXtQ" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="92" />
+                      </Parameter>
+                      <Parameter id="wh-eWa1ZeUyWkOIBiiqmLQ" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.853">
+                        <Info min="0" max="1" flag="50" seq="1" ref="0" bb="32" group="92" />
+                      </Parameter>
+                      <Container id="4EAMhITjf0qO7iFTXsHuTg" name="Aciclovir" mode="Logical" containerType="Molecule" />
+                    </Children>
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="35" ref="0" bb="32" group="92" />
+                  </DistributedParameter>
+                  <DistributedParameter id="ko-XLGM0s02x6POghutPeA" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="hUmYfKP8EkC7rKaHF8Z9fA" mode="Logical" isDefault="1">
+                    <Children>
+                      <Parameter id="2vCv7T3iP0is25JHS_mS_g" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="95" />
+                      </Parameter>
+                      <Parameter id="tXCPJgAUgEueuwNG1pulEQ" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.92">
+                        <Info min="0" max="1" flag="50" seq="1" ref="0" bb="32" group="95" />
+                      </Parameter>
+                      <Container id="oD3vRCmFTUCqhi-Cnnx5IQ" name="Aciclovir" mode="Logical" containerType="Molecule" />
+                    </Children>
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="35" ref="0" bb="32" group="95" />
+                  </DistributedParameter>
+                  <DistributedParameter id="d-ndP3P5l0Oj6cDAlkNO6g" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="K8YELbfnZUSgGF_jNm7cAA" mode="Logical" isDefault="1">
+                    <Children>
+                      <Parameter id="tMSIYOEczkWiczyNJei-Ug" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="92" />
+                      </Parameter>
+                      <Parameter id="TliNAWc6xk-GtV0fOjT20g" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0016">
+                        <Info min="0" max="1" flag="50" seq="1" ref="0" bb="32" group="92" />
+                      </Parameter>
+                      <Container id="3hebV1FXLEGAcin4569ZuA" name="Aciclovir" mode="Logical" containerType="Molecule" />
+                    </Children>
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="36" ref="0" bb="32" group="92" />
+                  </DistributedParameter>
+                  <DistributedParameter id="3WrGY6eycU6uKPcYq8vG_A" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="xlFacgbD6k-6hTE_Ejhf7g" mode="Logical" isDefault="1">
+                    <Children>
+                      <Parameter id="b2JfxrdLTUOGT8kj2QUL0w" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="95" />
+                      </Parameter>
+                      <Parameter id="tlSD51Ks3067q4IbFzkPcQ" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.002024">
+                        <Info min="0" max="1" flag="50" seq="1" ref="0" bb="32" group="95" />
+                      </Parameter>
+                      <Container id="M9eEWZOsjkGwy46TtrJQKQ" name="Aciclovir" mode="Logical" containerType="Molecule" />
+                    </Children>
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="36" ref="0" bb="32" group="95" />
+                  </DistributedParameter>
+                  <DistributedParameter id="3m_2itPaRUeXH4_JM3X5CA" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="i_85eyQzXUOhech7cYjTEw" mode="Logical" isDefault="1">
+                    <Children>
+                      <Parameter id="xCGhpMQIYUaTY4Bu9U2X3Q" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="92" />
+                      </Parameter>
+                      <Parameter id="R_tLRrZHP02t8mI_-ndJCg" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.135">
+                        <Info min="0" max="1" flag="50" seq="1" ref="0" bb="32" group="92" />
+                      </Parameter>
+                      <Container id="l75M1_4j2kSLDz_1l054Gw" name="Aciclovir" mode="Logical" containerType="Molecule" />
+                    </Children>
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="37" ref="0" bb="32" group="92" />
+                  </DistributedParameter>
+                  <DistributedParameter id="1m7rUfB2KE-EawoF9WE93w" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="wMDmilY1rUiol8oxSC0o7A" mode="Logical" isDefault="1">
+                    <Children>
+                      <Parameter id="CrcyfkRvtESIaPNLqFYmuw" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="92" />
+                      </Parameter>
+                      <Parameter id="sak9u8pK1kGm9ba6ZJa_Dg" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.00899999999999998">
+                        <Info min="0" max="1" flag="50" seq="1" ref="0" bb="32" group="92" />
+                      </Parameter>
+                      <Container id="W1Xllg57_0-KOP3XfsszQA" name="Aciclovir" mode="Logical" containerType="Molecule" />
+                    </Children>
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="38" ref="0" bb="32" group="92" />
+                  </DistributedParameter>
+                  <DistributedParameter id="BIgAx7t_n0ufGF53BucQzw" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="B1T7ynKEWEGrtplAKJYe0Q" mode="Logical" isDefault="1">
+                    <Children>
+                      <Parameter id="-oHEfT_5LEaKbA_OjWjr_A" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="95" />
+                      </Parameter>
+                      <Parameter id="FfLuel-BxUmiR5VrKdWwJg" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.03">
+                        <Info min="0" max="1" flag="50" seq="1" ref="0" bb="32" group="95" />
+                      </Parameter>
+                      <Container id="61mbQmrjRkCnpDUeoCexxQ" name="Aciclovir" mode="Logical" containerType="Molecule" />
+                    </Children>
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="38" ref="0" bb="32" group="95" />
+                  </DistributedParameter>
+                  <DistributedParameter id="3E6rB-kAvU6q0z5KFTb-Uw" name="Specific blood flow rate" description="Blood flow rate normalized to the organ volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" formula="uFEmxj1kuEa2PvNHj8_3ig" mode="Logical" isDefault="1" displayUnit="ml/min/100g organ">
+                    <Children>
+                      <Parameter id="cC9VPvBG-EWlVy4CC2mwPg" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="5" />
+                      </Parameter>
+                      <Parameter id="x0e-QJ6Fq0C0Qo-ulc54vg" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.02184" displayUnit="ml/min/100g organ">
+                        <Info min="0" flag="50" seq="1" ref="0" bb="32" group="5" />
+                      </Parameter>
+                      <Parameter id="C4nSbz5CbkmpWLnH6GhvnQ" name="Deviation" description="Standard deviation of Normal distribution" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.001092" displayUnit="ml/min/100g organ">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="5" />
+                      </Parameter>
+                      <Container id="ThFyVkPjBEmBusgMuN9lhw" name="Aciclovir" mode="Logical" containerType="Molecule" />
+                    </Children>
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="40" source="Publication" description="Edginton, A.N., Schmitt, W. &amp; Willmann, S. Clin Pharmacokinet (2006) 45: 1013. https://doi.org/10.2165/00003088-200645100-00005" />
+                    <Info min="0" flag="122" seq="41" ref="0" bb="32" group="5" />
+                  </DistributedParameter>
+                  <Container id="jJKX8FGI-UO3bnlzFyUdjw" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
+                    <Tags>
+                      <Tag value="Fat" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="uMQgru4-uEGjWg3w3PG-zw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="WiDWMA7xi02WdVvl1Rjr0g" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="qWF3Uy6yZECZAkBLDFbRSA" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="yYX4DjDwkEOGUvd-DF06pA" isDefault="1" displayUnit="l">
+                        <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                        <Info min="0" flag="62" seq="7" ref="0" bb="2" group="126" />
+                      </Parameter>
+                      <MoleculeAmount id="64FV2p1yekWw0IXk5Srxkw" name="CYP344" icon="ENZYME" persistable="0" isFixedValue="0" dim="Amount" quantityType="Enzyme" negativeValuesAllowed="0" formula="rMXLZglcaUaofPZ0c6I6Yw" mode="Logical" scaleDivisor="1" displayUnit="µmol">
+                        <Children>
+                          <Parameter id="NhZzWazVD0ilP4OyMi5Kbw" name="Degradation coefficient" description="First order turnover rate constant of the enzyme" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="c2fNMePAyki4XPdR-AEHaQ" isDefault="1" displayUnit="1/min">
+                            <ValueOrigin id="33" source="Other" description="OSP Suite Manual Chapter 16. PK-Sim®- Compounds: Defining inhibition/induction processes" />
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="ZRKDN7GoUUiOEebZwfGNCQ" name="Relative expression" description="Relative expression" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="fqrxyq94VkWMTLJeRjjhEQ" isDefault="1">
+                            <Info min="0" flag="60" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="NItFmSMhx0WVRIYIYjoBMQ" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="YQ_SIzoIak2o9B3xCbLazA" isDefault="1">
+                            <Info min="0" flag="58" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="hNdA7W_ahE21bMSKW6URnQ" name="Relative expression out." description="Relative Expression that will be used in the simulation" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="fbRCNZOks0i0JlaOaYnbvg" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="udGUCNKc6kS1f0EveQG9jw" name="Start amount" description="Start amount of molecule" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" formula="EPX-QNxBZE2pcwiBNY6NfA" isDefault="1" displayUnit="µmol">
+                            <Info flag="54" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="jvTQH8in5UiL91N5GUC2zg" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="_5AQF4X5mkuTWnIB24ghvw" isDefault="1" displayUnit="µmol/l">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Parameter id="OjNROjbN6ECQG1QQxmcN1A" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="3oDFFkqayUu9G7HP9-VJIQ" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                          </Parameter>
+                          <Parameter id="B3rgQeXoDUKu0DDEg3qy4Q" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="7JApAJThRUq440OAPRGT6w" isDefault="1" displayUnit="min">
+                            <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Observer id="9MF2Xv6wzkKWAQEjCMvM4g" name="Concentration in container" description="Concentration of the molecule" icon="Observer" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Enzyme, Observer" negativeValuesAllowed="1" formula="6wCmGaSt3UirOnRpXv6unA" displayUnit="µmol/l" />
+                        </Children>
+                      </MoleculeAmount>
+                      <MoleculeAmount id="clnPhL5JykSeqIuCVtRsRg" name="Aciclovir" icon="DRUG" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" negativeValuesAllowed="0" mode="Logical" scaleDivisor="1" value="0" displayUnit="µmol">
+                        <Children>
+                          <Parameter id="OcUpJf91YkefKPuY5ju3Jw" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="_5AQF4X5mkuTWnIB24ghvw" isDefault="1" displayUnit="µmol/l">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Parameter id="hgMmFv1mnUCpZJOsSgU5NA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="1BhfYgYrgk2w01HX52NXfA" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                          </Parameter>
+                          <Observer id="DNWf05qsPEmdpfa5SjV3Dg" name="Concentration in container" description="Concentration of the molecule" icon="Observer" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" negativeValuesAllowed="1" formula="6wCmGaSt3UirOnRpXv6unA" displayUnit="µmol/l" />
+                        </Children>
+                      </MoleculeAmount>
+                    </Children>
+                  </Container>
+                  <Container id="NZxOvgCsl0KK1TCHgZbMYg" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
+                    <Tags>
+                      <Tag value="Fat" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="1ihesvnTnkaLYnA7CMEJWg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="WiDWMA7xi02WdVvl1Rjr0g" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="V7vQPFaT70ifvJaUSIjIlg" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="H_SN9-_mbUGRPDaFmFf1dQ" isDefault="1" displayUnit="l">
+                        <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                        <Info min="0" flag="62" seq="7" ref="0" bb="2" group="121" />
+                      </Parameter>
+                      <MoleculeAmount id="THZJCXqQZkCgQgzgLEGOnw" name="CYP344" icon="ENZYME" persistable="0" isFixedValue="0" dim="Amount" quantityType="Enzyme" negativeValuesAllowed="0" formula="rMXLZglcaUaofPZ0c6I6Yw" mode="Logical" scaleDivisor="1" displayUnit="µmol">
+                        <Children>
+                          <Parameter id="IRaz6p_QxUalpIWgF1czmA" name="Degradation coefficient" description="First order turnover rate constant of the enzyme" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="c2fNMePAyki4XPdR-AEHaQ" isDefault="1" displayUnit="1/min">
+                            <ValueOrigin id="33" source="Other" description="OSP Suite Manual Chapter 16. PK-Sim®- Compounds: Defining inhibition/induction processes" />
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="ukdqw7adjkuu4e_puugMlg" name="Relative expression" description="Relative expression" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="cLw6IJb0kk-aHdh1YkXHkw" isDefault="1">
+                            <Info min="0" flag="60" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="n8ntr096502fC19-J3pzJQ" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="xTktpLRZC0e7-rlZenlyLg" isDefault="1">
+                            <Info min="0" flag="58" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="rAI2bnpAUkKvNDy7jie6fA" name="Relative expression out." description="Relative Expression that will be used in the simulation" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="fbRCNZOks0i0JlaOaYnbvg" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="ngwNpUoxpEGBKYcXOF2HhQ" name="Start amount" description="Start amount of molecule" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" formula="EPX-QNxBZE2pcwiBNY6NfA" isDefault="1" displayUnit="µmol">
+                            <Info flag="54" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="2KgZ2JCnIky2PUyOCHDTHA" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="_5AQF4X5mkuTWnIB24ghvw" isDefault="1" displayUnit="µmol/l">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Parameter id="Mqgcq7YOZEu1MUwkRR3ZgQ" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="jRbB-h0WgkW-tqTYzc1CuA" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                          </Parameter>
+                          <Parameter id="VqySZC7YXEWN25prCvifww" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="GDf3MVm2XU--7aarrVRoPg" isDefault="1" displayUnit="min">
+                            <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Observer id="aiFU9fptxUO6SVh7CR1IRQ" name="Concentration in container" description="Concentration of the molecule" icon="Observer" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Enzyme, Observer" negativeValuesAllowed="1" formula="6wCmGaSt3UirOnRpXv6unA" displayUnit="µmol/l" />
+                        </Children>
+                      </MoleculeAmount>
+                      <MoleculeAmount id="VyJX6uklU0KkdB4Y0-tVow" name="Aciclovir" icon="DRUG" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" negativeValuesAllowed="0" mode="Logical" scaleDivisor="1" value="0" displayUnit="µmol">
+                        <Children>
+                          <Parameter id="1NGkgDENJEiCinGwrKPFtQ" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="_5AQF4X5mkuTWnIB24ghvw" isDefault="1" displayUnit="µmol/l">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Parameter id="iBJURpLdDEKeibgRQQPG2Q" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="mgUhez-RnEuC1LIO0H6KVw" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                          </Parameter>
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+                        </Children>
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+                    </Children>
+                  </Container>
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+                    <Tags>
+                      <Tag value="Fat" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="sOHlsgWgN0-EDm00aHcP4w" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="WiDWMA7xi02WdVvl1Rjr0g" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="-96U8tiuCkaBQhFXhby8Pg" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="9uWm2G1z9EK-p6oBMLbcVA" isDefault="1" displayUnit="l">
+                        <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                        <Info min="0" flag="62" seq="7" ref="0" bb="2" group="124" />
+                      </Parameter>
+                      <Parameter id="O6vhAtqA0ky_iImiZRH1Ew" name="pH" description="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="eK4DKfgMbEONwPdNpejUig" isDefault="1">
+                        <Tags>
+                          <Tag value="Fat" />
+                        </Tags>
+                        <Info min="0" max="14" flag="122" seq="23" ref="0" bb="32" group="84" />
+                      </Parameter>
+                      <MoleculeAmount id="MO350Jid4Uy-RDivvJCeAg" name="Aciclovir" icon="DRUG" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" negativeValuesAllowed="0" mode="Logical" scaleDivisor="1" value="0" displayUnit="µmol">
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+                          <Parameter id="zgOe4k1rGEisO4jx6cwomg" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="_5AQF4X5mkuTWnIB24ghvw" isDefault="1" displayUnit="µmol/l">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Parameter id="N7M4jx6InkyL8U56vVPh9g" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="8ADeUyBa9EWChqFmofLLdQ" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                          </Parameter>
+                          <Observer id="oRpy7GNXmk2qUmiueO320Q" name="Concentration in container" description="Concentration of the molecule" icon="Observer" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" negativeValuesAllowed="1" formula="6wCmGaSt3UirOnRpXv6unA" displayUnit="µmol/l" />
+                        </Children>
+                      </MoleculeAmount>
+                    </Children>
+                  </Container>
+                  <Container id="vSG3Se6VokOfPMnJgaNt6g" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
+                    <Tags>
+                      <Tag value="Fat" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="lhIraG9cpkW5q0uXX18mTw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="J_zsXA_hVEGtRM46zqPvJg" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="YRubUjhg3UC5SfW4SebuJw" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="GXZJgB5-lEOADgF16J9WjQ" isDefault="1" displayUnit="l">
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+                        <Info min="0" flag="62" seq="7" ref="0" bb="2" group="125" />
+                      </Parameter>
+                      <Parameter id="iXaTHcYioEW59Vf5dBufUg" name="pH" description="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.1">
+                        <Tags>
+                          <Tag value="Fat" />
+                        </Tags>
+                        <ValueOrigin id="34" source="Publication" description="Toxicol In Vitro. 2008 Mar;22(2):457-67 https://doi.org/10.1016/j.tiv.2007.09.010" />
+                        <Info min="0" max="14" flag="122" seq="23" ref="0" bb="32" group="83" />
+                      </Parameter>
+                      <MoleculeAmount id="9Ye_e-IcoU6Pu7q8jRn0kw" name="CYP344" icon="ENZYME" persistable="0" isFixedValue="0" dim="Amount" quantityType="Enzyme" negativeValuesAllowed="0" formula="rMXLZglcaUaofPZ0c6I6Yw" mode="Logical" scaleDivisor="1" displayUnit="µmol">
+                        <Children>
+                          <Parameter id="WQK8xRxed0OWqzt26o8Udg" name="Degradation coefficient" description="First order turnover rate constant of the enzyme" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="c2fNMePAyki4XPdR-AEHaQ" isDefault="1" displayUnit="1/min">
+                            <ValueOrigin id="33" source="Other" description="OSP Suite Manual Chapter 16. PK-Sim®- Compounds: Defining inhibition/induction processes" />
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="ze86wgSWlUqOUFnit6zp6Q" name="Relative expression" description="Relative expression" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0">
+                            <Info min="0" flag="60" seq="1" ref="0" bb="32" group="91" />
+                          </Parameter>
+                          <Parameter id="ckR1_1wBIUWHvMnqdCAp5w" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0">
+                            <Info min="0" flag="58" seq="1" ref="0" bb="32" group="91" />
+                          </Parameter>
+                          <Parameter id="Dtj1AvQZTEapdNIWgW8-Tg" name="Relative expression out." description="Relative Expression that will be used in the simulation" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="fbRCNZOks0i0JlaOaYnbvg" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="VD1qOl-BUUuNpEQpp0GaUg" name="Start amount" description="Start amount of molecule" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" formula="EPX-QNxBZE2pcwiBNY6NfA" isDefault="1" displayUnit="µmol">
+                            <Info flag="54" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="O-So-88r50qhoyFzDL0nGg" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="_5AQF4X5mkuTWnIB24ghvw" isDefault="1" displayUnit="µmol/l">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Parameter id="5WzyXIb6fUW_MbGoDVaKVA" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ZdgT6dH47UiwRlfA4aHaaA" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                          </Parameter>
+                          <Parameter id="hxcHfZcNx0O15TKVQLz7eg" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="PXSP6vHCz0OCknQr-KCFog" isDefault="1" displayUnit="min">
+                            <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Observer id="TD50tHDlbk-IRC5JFpp5Ow" name="Concentration in container" description="Concentration of the molecule" icon="Observer" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Enzyme, Observer" negativeValuesAllowed="1" formula="6wCmGaSt3UirOnRpXv6unA" displayUnit="µmol/l" />
+                        </Children>
+                      </MoleculeAmount>
+                      <MoleculeAmount id="B5UZeYaVIU26mxhCdDiJUQ" name="Aciclovir" icon="DRUG" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" negativeValuesAllowed="0" mode="Logical" scaleDivisor="1" value="0" displayUnit="µmol">
+                        <Children>
+                          <Parameter id="OIUzzXucR0KeObcyYvvPaQ" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="_5AQF4X5mkuTWnIB24ghvw" isDefault="1" displayUnit="µmol/l">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Parameter id="2RmO-VHc4Eu2Cs9m0Pz2Qw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="W0wZMgokOE6W3cyhiJBzzA" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                          </Parameter>
+                          <Observer id="C6tbsgH3rU-tzRfeyekkYQ" name="Concentration in container" description="Concentration of the molecule" icon="Observer" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" negativeValuesAllowed="1" formula="6wCmGaSt3UirOnRpXv6unA" displayUnit="µmol/l" />
+                        </Children>
+                      </MoleculeAmount>
+                    </Children>
+                  </Container>
+                  <Container id="yFACK1KziUe-BsxUmDhx0A" name="Aciclovir" mode="Logical" containerType="Molecule">
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+                      <Observer id="H56PZq_bSUKwwUM71MgNwA" name="Interstitial Unbound" description="Interstitial Unbound" icon="Observer" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" negativeValuesAllowed="1" formula="9puGFowK4EWaB_uKiCUkZg" displayUnit="µmol/l" />
+                      <Observer id="4arwa4jLB0msoOcZP-OL0w" name="Intracellular Unbound" description="Intracellular Unbound" icon="Observer" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" negativeValuesAllowed="1" formula="teOQNDXPokGxR8_kXybQ_A" displayUnit="µmol/l" />
+                      <Observer id="pBhe8kCAe0OvJuwlfWuOng" name="Tissue" description="Tissue" icon="Observer" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" negativeValuesAllowed="1" formula="vXvnx5OPgEOFlJ6Oq1kSGw" displayUnit="µmol/l" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Container>
+              <Container id="yofbJKQ45Uu2AdHIz7L8xg" name="Gonads" description="Gonads" icon="Gonads" mode="Logical" containerType="Organ">
+                <Tags>
+                  <Tag value="TissueOrgan" />
+                </Tags>
+                <Children>
+                  <Parameter id="VaftnYm2RkKkp2-DJy7hLQ" name="Weight (tissue)" description="Weight of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="fliUWazsPUiRy_qjzM6EaA" isDefault="1" displayUnit="kg">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
+                  </Parameter>
+                  <Parameter id="wMPA_OL-DE2Kw66AwNJShw" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="SEONXx9l8UekWRlG-vCS6A" isDefault="1" displayUnit="l/min">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
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+                    <Info min="0" flag="122" seq="10" ref="0" bb="32" group="27" />
+                  </Parameter>
+                  <Parameter id="r-L1LCTKnEq85kQG2jViIw" name="Lymph flow rate" description="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="AHUOFh7VvEGdn9pbFbN0Ng" isDefault="1" displayUnit="l/min">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
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+                    <Info min="0" flag="122" seq="10" ref="0" bb="32" group="58" />
+                  </Parameter>
+                  <Parameter id="39hey056UES_WWRRPCf27w" name="Volume (endothelium)" description="Volume of  vascular endothelium" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="gzCTpHiUTE-KC_iQsO1czA" isDefault="1" displayUnit="l">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="62" seq="10" ref="0" bb="32" group="127" />
+                  </Parameter>
+                  <Parameter id="uli8GTrJKE6CZWLiBUEOZg" name="Fraction intracellular" description="Fraction of intracellular space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="I-HZynBcWEaZVIcFkF3iMQ" isDefault="1">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
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+                    <Info min="0" max="1" flag="62" seq="31" ref="0" bb="32" group="64" />
+                  </Parameter>
+                  <Parameter id="SB1HTslge0SURB8LTU-uoA" name="Blood flow rate" description="Organ blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="y6LwIbRu9ku8erXKf1RN9w" isDefault="1" displayUnit="l/min">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="48" source="Other" description="Absolute value = specific value (i.e. value normalized to the volume of the organ) multiplied by the organ volume" />
+                    <Info min="0" flag="62" seq="62" ref="0" bb="32" group="5" />
+                  </Parameter>
+                  <Parameter id="wcm6_rlGmka-y4WxW9lwyg" name="Density (tissue)" description="Density of tissue" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="38" seq="1" ref="0" bb="32" group="21" />
+                  </Parameter>
+                  <Parameter id="gvgFZhF2h0aC9c6eI89ljw" name="Fluid recirculation flow proportionality factor" description="proportionality factor linking fluid recirculation flow to lymph flow via small pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.96">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="27" />
+                  </Parameter>
+                  <Parameter id="lXDzvAyoOkm3JP9ErwpfAw" name="Lymph flow proportionality factor" description="Proportionality factor linking lymph flow to plasma flow" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0111">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="58" />
+                  </Parameter>
+                  <Parameter id="bjqhbfd3V0CVnvdy8g6mvA" name="Organ volume mouse" description="Organ volume mouse" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.00025" displayUnit="l">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
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+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="65" />
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+                  <Parameter id="BXejPcJoIU6ff2cER71gZg" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.75">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0.75" max="0.75" flag="54" seq="1" ref="0" bb="32" group="2" />
+                  </Parameter>
+                  <Parameter id="kiOcZyjya0urnbudl5cZ8Q" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
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+                    <Info min="0" max="1" flag="54" seq="1" ref="0" bb="32" group="94" />
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+                  <Parameter id="gyIf6Zp4ekKGPQiOz2GTtA" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.05">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
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+                    <Info min="0" max="1" flag="122" seq="10" ref="0" bb="32" group="114" />
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+                  <Parameter id="APs728Ly_k6k7JhYSWmrzA" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" icon="Parameter" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="9E-12" displayUnit="ml/min/N">
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+                      <Tag value="TissueOrgan" />
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+                    <Info min="0" flag="122" seq="10" ref="0" bb="32" group="115" />
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+                  <Parameter id="BDzFWBrZlUGvvta3VgK-Qw" name="Radius (large pores)" description="Large endothelial pores radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.5E-07" displayUnit="µm">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
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+                    <Info min="0" flag="122" seq="10" ref="0" bb="32" group="55" />
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+                  <Parameter id="wHVaO0D6p0mzNYAPYptDcQ" name="Radius (small pores)" description="Small endothelial pores radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="4.5E-08" displayUnit="µm">
+                    <Tags>
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+                  <Parameter id="1tt_9M8R_E-XuYlYCcBV2A" name="Fraction vascular" description="Fraction of vascular space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.055">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="40" source="Publication" description="Edginton, A.N., Schmitt, W. &amp; Willmann, S. Clin Pharmacokinet (2006) 45: 1013. https://doi.org/10.2165/00003088-200645100-00005" />
+                    <Info min="0" max="1" flag="62" seq="30" ref="0" bb="32" group="64" />
+                  </Parameter>
+                  <Parameter id="anN92BoxHEuT6Pzwug-LBQ" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.031">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
+                    <Info min="0" max="1" flag="122" seq="30" ref="0" bb="32" group="85" />
+                  </Parameter>
+                  <Parameter id="EG30Xs9fo0GQP1WERHOORg" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0048">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="30" ref="0" bb="32" group="86" />
+                  </Parameter>
+                  <Parameter id="3NkwJhjD_0CrS5voE32SuA" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.01405">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="31" ref="0" bb="32" group="86" />
+                  </Parameter>
+                  <Parameter id="RZ-ATFidWU2U0YFIm_2HGw" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.12">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
+                    <Info min="0" max="1" flag="122" seq="31" ref="0" bb="32" group="85" />
+                  </Parameter>
+                  <Parameter id="ZRsfYVszxUuQxKbFLB_-qg" name="Fraction interstitial" description="Fraction of interstitial space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.069">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="40" source="Publication" description="Edginton, A.N., Schmitt, W. &amp; Willmann, S. Clin Pharmacokinet (2006) 45: 1013. https://doi.org/10.2165/00003088-200645100-00005" />
+                    <Info min="0" max="1" flag="62" seq="32" ref="0" bb="32" group="64" />
+                  </Parameter>
+                  <Parameter id="00Ecq82lAU2jpkFUGmdDtg" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.048">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="32" ref="0" bb="32" group="111" />
+                  </Parameter>
+                  <Parameter id="qm58YA4X30-N4iRGWr2vIg" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="24" source="Publication" description="POULIN P, THEIL F. Prediction of Pharmacokinetics Prior to In Vivo Studies. 1. Mechanism-Based Prediction of Volume of Distribution. JOURNAL OF PHARMACEUTICAL SCIENCES, VOL. 91, NO. 1, JANUARY 2002" />
+                    <Info min="0" max="1" flag="122" seq="32" ref="0" bb="32" group="112" />
+                  </Parameter>
+                  <Parameter id="jogWm76Dj0-qaZqVKq4nng" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.041">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="32" ref="0" bb="32" group="113" />
+                  </Parameter>
+                  <Parameter id="T9AyrdBQT0msxMW9YQVWtA" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.8">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
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+                    <Info min="0" max="1" flag="122" seq="32" ref="0" bb="32" group="85" />
+                  </Parameter>
+                  <Parameter id="zFvBGiHWo0WdyHykEb-iog" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.8">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="32" ref="0" bb="32" group="86" />
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+                  <Parameter id="mMwb4sjNFk6nAy9wNydkhg" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0048">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="50" ref="0" bb="32" group="92" />
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+                  <Parameter id="9mhcMwQJW0y5Dgmr2MV0ew" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="50" ref="0" bb="32" group="95" />
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+                  <Parameter id="VmCmh9frQ0SxS9DfAHzIIw" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0116">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="51" ref="0" bb="32" group="92" />
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+                  <Parameter id="HkRJn7qUok-qdsgJz730tQ" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0249">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="51" ref="0" bb="32" group="95" />
+                  </Parameter>
+                  <Parameter id="zFbprB4SMEqpQiGVzfg9Fg" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.03">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="20" source="Publication" description="Rodgers T, Leahy D, Rowland M. Tissue distribution of basic drugs: accounting for enantiomeric, compound and regional differences amongst beta-blocking drugs in rat. J Pharm Sci. 2005 Jun;94(6):1237-48. https://doi.org/10.1002/jps.20323" />
+                    <Info min="0" max="1" flag="122" seq="52" ref="0" bb="32" group="92" />
+                  </Parameter>
+                  <Parameter id="YZvfTGdDz0aBivlhDMffHA" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.13">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="52" ref="0" bb="32" group="95" />
+                  </Parameter>
+                  <Parameter id="oxEED0arp0-dtYxpKODV-Q" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.83">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="20" source="Publication" description="Rodgers T, Leahy D, Rowland M. Tissue distribution of basic drugs: accounting for enantiomeric, compound and regional differences amongst beta-blocking drugs in rat. J Pharm Sci. 2005 Jun;94(6):1237-48. https://doi.org/10.1002/jps.20323" />
+                    <Info min="0" max="1" flag="122" seq="53" ref="0" bb="32" group="92" />
+                  </Parameter>
+                  <Parameter id="lBVPTFzGUUSCO0xYwaxVrA" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.78">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="53" ref="0" bb="32" group="95" />
+                  </Parameter>
+                  <Parameter id="ns6lZCrybUWLqH5R2g2_vg" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.45">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="20" source="Publication" description="Rodgers T, Leahy D, Rowland M. Tissue distribution of basic drugs: accounting for enantiomeric, compound and regional differences amongst beta-blocking drugs in rat. J Pharm Sci. 2005 Jun;94(6):1237-48. https://doi.org/10.1002/jps.20323" />
+                    <Info min="0" max="1000" flag="122" seq="54" ref="0" bb="32" group="92" />
+                  </Parameter>
+                  <Parameter id="erWkUjkask6o0O-_pgyp5Q" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0054">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="54" ref="0" bb="32" group="95" />
+                  </Parameter>
+                  <DistributedParameter id="pJu4cW2IOkm_Uqnrz1BXUA" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="huOy9LuuK0SCTqPAIieteA" mode="Logical" isDefault="1" displayUnit="l">
+                    <Children>
+                      <Parameter id="12HRwqD9UEKurmbfumOhKQ" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.50001668930209">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="65" />
+                      </Parameter>
+                      <Parameter id="GTH7rM0TAEyklSkdrFJK1g" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.040268154912" displayUnit="l">
+                        <Info min="0" flag="34" seq="1" ref="0" bb="32" group="65" />
+                      </Parameter>
+                      <Parameter id="xmugFWy8xk-omZ2p0Snsrg" name="Deviation" description="Standard deviation of Normal distribution" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0020134077456" displayUnit="l">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="65" />
+                      </Parameter>
+                      <Container id="1aZuFugJhk2znQP8X4O8MQ" name="Aciclovir" mode="Logical" containerType="Molecule" />
+                    </Children>
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
+                    <Info min="0" flag="106" seq="5" ref="0" bb="32" group="65" />
+                  </DistributedParameter>
+                  <DistributedParameter id="jgp_N9jRU02Wu9CRlhvh3Q" name="Specific blood flow rate" description="Blood flow rate normalized to the organ volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" formula="RGqUWoAVxEe5z9r0PSxK8Q" mode="Logical" isDefault="1" displayUnit="ml/min/100g organ">
+                    <Children>
+                      <Parameter id="REgriqSyrU2Mgx0rc5_70g" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="5" />
+                      </Parameter>
+                      <Parameter id="2K62BLEzHEiq9RRWNkUK4Q" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0806" displayUnit="ml/min/100g organ">
+                        <Info min="0" flag="50" seq="1" ref="0" bb="32" group="5" />
+                      </Parameter>
+                      <Parameter id="2cMIdHNQDUiXRIKPdroQow" name="Deviation" description="Standard deviation of Normal distribution" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.00403" displayUnit="ml/min/100g organ">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="5" />
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+                      <Container id="35vq3VmwDE2nBe4hjchF3g" name="Aciclovir" mode="Logical" containerType="Molecule" />
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+                    <Tags>
+                      <Tag value="TissueOrgan" />
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+                    <ValueOrigin id="40" source="Publication" description="Edginton, A.N., Schmitt, W. &amp; Willmann, S. Clin Pharmacokinet (2006) 45: 1013. https://doi.org/10.2165/00003088-200645100-00005" />
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+                    <Tags>
+                      <Tag value="Gonads" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="dOlzBs7WhEyAyx1y2mRZ4Q" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="WiDWMA7xi02WdVvl1Rjr0g" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="4_3zoixFyka3v34PvvRIjQ" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="yYX4DjDwkEOGUvd-DF06pA" isDefault="1" displayUnit="l">
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+                        <Info min="0" flag="62" seq="10" ref="0" bb="2" group="126" />
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+                      <MoleculeAmount id="Ijad0xycR0ih69z8XFjCAg" name="CYP344" icon="ENZYME" persistable="0" isFixedValue="0" dim="Amount" quantityType="Enzyme" negativeValuesAllowed="0" formula="rMXLZglcaUaofPZ0c6I6Yw" mode="Logical" scaleDivisor="1" displayUnit="µmol">
+                        <Children>
+                          <Parameter id="pgwPnlzTJEqXB6U90cWibw" name="Degradation coefficient" description="First order turnover rate constant of the enzyme" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="c2fNMePAyki4XPdR-AEHaQ" isDefault="1" displayUnit="1/min">
+                            <ValueOrigin id="33" source="Other" description="OSP Suite Manual Chapter 16. PK-Sim®- Compounds: Defining inhibition/induction processes" />
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="KgzPYRCO9E-TdzGCMvJlTQ" name="Relative expression" description="Relative expression" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="fqrxyq94VkWMTLJeRjjhEQ" isDefault="1">
+                            <Info min="0" flag="60" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="T_r0ewRwj0mMWivMVqWO1w" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="YQ_SIzoIak2o9B3xCbLazA" isDefault="1">
+                            <Info min="0" flag="58" seq="1" ref="0" bb="2" group="91" />
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+                          <Parameter id="YdG2e2_7XESdIzyDsAggVw" name="Relative expression out." description="Relative Expression that will be used in the simulation" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="fbRCNZOks0i0JlaOaYnbvg" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="lhJDPnDzXUCR7kvBkSAWIw" name="Start amount" description="Start amount of molecule" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" formula="EPX-QNxBZE2pcwiBNY6NfA" isDefault="1" displayUnit="µmol">
+                            <Info flag="54" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="U3j8AUg0B0qdhsonwtsbXg" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="_5AQF4X5mkuTWnIB24ghvw" isDefault="1" displayUnit="µmol/l">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="2" group="117" />
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+                          <Parameter id="zcaOO6Gz0kaV9eJ2kIa6gA" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="N1x8TEmHt06-gS2cfNausA" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
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+                          <Parameter id="zID6ja7FIkqemLkUGWB_rg" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="xx8cpZxfhE6mxoNVLZ6b_Q" isDefault="1" displayUnit="min">
+                            <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Observer id="xSnrA-0hXku5ZBRqT57yWg" name="Concentration in container" description="Concentration of the molecule" icon="Observer" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Enzyme, Observer" negativeValuesAllowed="1" formula="6wCmGaSt3UirOnRpXv6unA" displayUnit="µmol/l" />
+                        </Children>
+                      </MoleculeAmount>
+                      <MoleculeAmount id="mMcNFJzp6EuhC5J9Oc0mGg" name="Aciclovir" icon="DRUG" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" negativeValuesAllowed="0" mode="Logical" scaleDivisor="1" value="0" displayUnit="µmol">
+                        <Children>
+                          <Parameter id="3cMUcmAXyUODvMjFo8TpRw" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="_5AQF4X5mkuTWnIB24ghvw" isDefault="1" displayUnit="µmol/l">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Parameter id="40uW3OjnZki5N9SlIozlbQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="3fTkWovB3E-b120hkkYZ2w" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                          </Parameter>
+                          <Observer id="Y_K0jPXwuEueJn2h3Sg1AQ" name="Concentration in container" description="Concentration of the molecule" icon="Observer" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" negativeValuesAllowed="1" formula="6wCmGaSt3UirOnRpXv6unA" displayUnit="µmol/l" />
+                        </Children>
+                      </MoleculeAmount>
+                    </Children>
+                  </Container>
+                  <Container id="gC60yfPKTkqclHndWv0AHA" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
+                    <Tags>
+                      <Tag value="Gonads" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="-1Oc1ORcDku33cpfylAlPg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="WiDWMA7xi02WdVvl1Rjr0g" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
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+                  <Parameter id="SmkJgEGSfE-5pBROB0sJAw" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.75">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0.75" max="0.75" flag="54" seq="1" ref="0" bb="32" group="2" />
+                  </Parameter>
+                  <Parameter id="lEVPzuGbXEKDKWPw52unXA" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="54" seq="1" ref="0" bb="32" group="94" />
+                  </Parameter>
+                  <Parameter id="378I-lioN02UZKtO7fkQxA" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.05">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" max="1" flag="122" seq="11" ref="0" bb="32" group="114" />
+                  </Parameter>
+                  <Parameter id="KG5sJT7xBUaRfuEqDjOroQ" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" icon="Parameter" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.43333333333333E-11" displayUnit="ml/min/N">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="11" ref="0" bb="32" group="115" />
+                  </Parameter>
+                  <Parameter id="m2W61uJhQUe7_ED3c3kNbw" name="Radius (large pores)" description="Large endothelial pores radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.5E-07" displayUnit="µm">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="11" ref="0" bb="32" group="55" />
+                  </Parameter>
+                  <Parameter id="6eJPzfV1IUuqBoyXmoS3Uw" name="Radius (small pores)" description="Small endothelial pores radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="4.5E-08" displayUnit="µm">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
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+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="11" ref="0" bb="32" group="99" />
+                  </Parameter>
+                  <Parameter id="HLoGh7Ofs0u8k3-j2uH7OQ" name="Fraction vascular" description="Fraction of vascular space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.14">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="40" source="Publication" description="Edginton, A.N., Schmitt, W. &amp; Willmann, S. Clin Pharmacokinet (2006) 45: 1013. https://doi.org/10.2165/00003088-200645100-00005" />
+                    <Info min="0" max="1" flag="62" seq="33" ref="0" bb="32" group="64" />
+                  </Parameter>
+                  <Parameter id="EQDw-jMHfE-zQF_p-oFqkg" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.1">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
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+                    <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
+                    <Info min="0" max="1" flag="122" seq="33" ref="0" bb="32" group="85" />
+                  </Parameter>
+                  <Parameter id="ungTIid1j0WT_lBH8vTYlg" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0115">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="33" ref="0" bb="32" group="86" />
+                  </Parameter>
+                  <Parameter id="3IRev5v9M0yQIpeZ5cbR5A" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0166">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
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+                    <Info min="0" max="1" flag="122" seq="34" ref="0" bb="32" group="86" />
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+                  <Parameter id="40e325kPwE-dhUXIREUpcA" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.168">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
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+                    <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
+                    <Info min="0" max="1" flag="122" seq="34" ref="0" bb="32" group="85" />
+                  </Parameter>
+                  <Parameter id="I-3JWRQ1oEGKpBRzOt3oJQ" name="Fraction interstitial" description="Fraction of interstitial space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.1">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="19" source="Publication" description="Kawai R, Lemaire M, Steimer JL, Bruelisauer A, Niederberger W, Rowland M. Physiologically based pharmacokinetic study on a cyclosporin derivative, SDZ IMM 125. J Pharmacokinet Biopharm. 1994 Oct;22(5):327-65." />
+                    <Info min="0" max="1" flag="62" seq="35" ref="0" bb="32" group="64" />
+                  </Parameter>
+                  <Parameter id="xoby72E86kiTSM0QX_2M4g" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.157">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
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+                    <ValueOrigin id="22" source="Publication" description="Rodgers T, Rowland M. Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J Pharm Sci. 2006 Jun;95(6):1238-57 https://doi.org/10.1002/jps.20502" />
+                    <Info min="0" max="1" flag="122" seq="35" ref="0" bb="32" group="111" />
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+                  <Parameter id="tccs_OauPE-EW3Y-_JjSgw" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
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+                    <ValueOrigin id="24" source="Publication" description="POULIN P, THEIL F. Prediction of Pharmacokinetics Prior to In Vivo Studies. 1. Mechanism-Based Prediction of Volume of Distribution. JOURNAL OF PHARMACEUTICAL SCIENCES, VOL. 91, NO. 1, JANUARY 2002" />
+                    <Info min="0" max="1" flag="122" seq="35" ref="0" bb="32" group="112" />
+                  </Parameter>
+                  <Parameter id="H_M0odP5f0eGOhIscPMPOA" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.16">
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+                      <Tag value="TissueOrgan" />
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+                    <Info min="0" max="1" flag="122" seq="35" ref="0" bb="32" group="113" />
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+                  <Parameter id="LpgRCUak1UexbpIPwAP-6Q" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.731">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
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+                    <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
+                    <Info min="0" max="1" flag="122" seq="35" ref="0" bb="32" group="85" />
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+                  <Parameter id="zFVv1zV21kiIeZLqucUBlQ" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.758">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="35" ref="0" bb="32" group="86" />
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+                  <Parameter id="NKEQYXQlDUuM4wzuELOnCQ" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0135">
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+                    <Info min="0" max="1" flag="122" seq="55" ref="0" bb="32" group="92" />
+                  </Parameter>
+                  <Parameter id="udSKalU5UE-O1kh5GHuiBA" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0528">
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+                    <Info min="0" max="1" flag="122" seq="55" ref="0" bb="32" group="95" />
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+                  <Parameter id="DtRFxZLZykmLAZSFfS_vxQ" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0106">
+                    <Tags>
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+                    <Info min="0" max="1" flag="122" seq="56" ref="0" bb="32" group="92" />
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+                    <Tags>
+                      <Tag value="TissueOrgan" />
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+                    <Info min="0" max="1" flag="122" seq="56" ref="0" bb="32" group="95" />
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+                    <Tags>
+                      <Tag value="TissueOrgan" />
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+                    <ValueOrigin id="21" source="Publication" description="Rodgers T, Leahy D, Rowland M. Physiologically based pharmacokinetic modeling 1: predicting the tissue distribution of moderate-to-strong bases. J Pharm Sci. 2005 Jun;94(6):1259-76. https://doi.org/10.1002/jps.20322" />
+                    <Info min="0" max="1" flag="122" seq="57" ref="0" bb="32" group="92" />
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+                  <Parameter id="4z0CO7hffEKWzIuVcV5cag" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.19">
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+                      <Tag value="TissueOrgan" />
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+                    <Info min="0" max="1" flag="122" seq="57" ref="0" bb="32" group="95" />
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+                  <Parameter id="UAZR4Z9o3kalYEV6ujW9_g" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.248">
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+                    <Info min="0" max="1" flag="122" seq="58" ref="0" bb="32" group="92" />
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+                  <Parameter id="YGpY7DSkV02xkEPSldTjuA" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.7">
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+                      <Tag value="TissueOrgan" />
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+                    <Info min="0" max="1" flag="122" seq="58" ref="0" bb="32" group="95" />
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+                    <Tags>
+                      <Tag value="TissueOrgan" />
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+                    <ValueOrigin id="21" source="Publication" description="Rodgers T, Leahy D, Rowland M. Physiologically based pharmacokinetic modeling 1: predicting the tissue distribution of moderate-to-strong bases. J Pharm Sci. 2005 Jun;94(6):1259-76. https://doi.org/10.1002/jps.20322" />
+                    <Info min="0" max="1000" flag="122" seq="59" ref="0" bb="32" group="92" />
+                  </Parameter>
+                  <Parameter id="hGBkomGhOEqaXL0Vbz8w0w" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0099">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
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+                    <Info min="0" max="1" flag="122" seq="59" ref="0" bb="32" group="95" />
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+                  <DistributedParameter id="sVSK-h71AUqud8SvVZ99lQ" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="uudPLnrCYU-FUwra4ibmiA" mode="Logical" isDefault="1" displayUnit="l">
+                    <Children>
+                      <Parameter id="RyNMX7QliUGIJbJS6qwDZA" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.501739202835752">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="65" />
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+                      <Parameter id="1H8jpw5c40Kuyh0S8bThwQ" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.4171997376" displayUnit="l">
+                        <Info min="0" flag="34" seq="1" ref="0" bb="32" group="65" />
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+                      <Parameter id="Qk0BBlAh2k6Y3H6YiPgamw" name="Deviation" description="Standard deviation of Normal distribution" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.079998771064368" displayUnit="l">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="65" />
+                      </Parameter>
+                      <Container id="exRSLJwszUmqQrKKvQmjFQ" name="Aciclovir" mode="Logical" containerType="Molecule" />
+                    </Children>
+                    <Tags>
+                      <Tag value="TissueOrgan" />
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+                    <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
+                    <Info min="0" flag="106" seq="6" ref="0" bb="32" group="65" />
+                  </DistributedParameter>
+                  <DistributedParameter id="8-Yu_RPo30-3VWsCZAE1DQ" name="Specific blood flow rate" description="Blood flow rate normalized to the organ volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" formula="p1JVTl5cDEysyyq_YEcMdA" mode="Logical" isDefault="1" displayUnit="ml/min/100g organ">
+                    <Children>
+                      <Parameter id="9547sS1AukC_HzsFylrXOQ" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="5" />
+                      </Parameter>
+                      <Parameter id="uggA9977dEen9oRmHbZPCA" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.62335" displayUnit="ml/min/100g organ">
+                        <Info min="0" flag="50" seq="1" ref="0" bb="32" group="5" />
+                      </Parameter>
+                      <Parameter id="me9nCGBRuUO8xZtNN5ti4g" name="Deviation" description="Standard deviation of Normal distribution" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0311675" displayUnit="ml/min/100g organ">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="5" />
+                      </Parameter>
+                      <Container id="2iluQMBQQUWKM0WXU6a6Nw" name="Aciclovir" mode="Logical" containerType="Molecule" />
+                    </Children>
+                    <Tags>
+                      <Tag value="TissueOrgan" />
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+                    <ValueOrigin id="40" source="Publication" description="Edginton, A.N., Schmitt, W. &amp; Willmann, S. Clin Pharmacokinet (2006) 45: 1013. https://doi.org/10.2165/00003088-200645100-00005" />
+                    <Info min="0" flag="122" seq="81" ref="0" bb="32" group="5" />
+                  </DistributedParameter>
+                  <Container id="Ql1dRMGROE-Xunwf1NB9cQ" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
+                    <Tags>
+                      <Tag value="Heart" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="6VMoM5igRUKS4J8_GEQC7A" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="WiDWMA7xi02WdVvl1Rjr0g" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
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+                      <Parameter id="tupNCCesGkOAeEIUZI6zuw" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="yYX4DjDwkEOGUvd-DF06pA" isDefault="1" displayUnit="l">
+                        <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                        <Info min="0" flag="62" seq="11" ref="0" bb="2" group="126" />
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+                      <MoleculeAmount id="dO-XDz-uJEa63Yb2FKrg2w" name="CYP344" icon="ENZYME" persistable="0" isFixedValue="0" dim="Amount" quantityType="Enzyme" negativeValuesAllowed="0" formula="rMXLZglcaUaofPZ0c6I6Yw" mode="Logical" scaleDivisor="1" displayUnit="µmol">
+                        <Children>
+                          <Parameter id="8n8yJKucR0-s47_xLRe9Cw" name="Degradation coefficient" description="First order turnover rate constant of the enzyme" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="c2fNMePAyki4XPdR-AEHaQ" isDefault="1" displayUnit="1/min">
+                            <ValueOrigin id="33" source="Other" description="OSP Suite Manual Chapter 16. PK-Sim®- Compounds: Defining inhibition/induction processes" />
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="K5c8gJbFykCB3MD5BtMN_g" name="Relative expression" description="Relative expression" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="fqrxyq94VkWMTLJeRjjhEQ" isDefault="1">
+                            <Info min="0" flag="60" seq="1" ref="0" bb="2" group="91" />
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+                    <Info min="0" flag="122" seq="12" ref="0" bb="32" group="99" />
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+                    <Info min="0" max="1" flag="122" seq="36" ref="0" bb="32" group="85" />
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+                    <Info min="0" max="1" flag="122" seq="37" ref="0" bb="32" group="85" />
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+                    <ValueOrigin id="19" source="Publication" description="Kawai R, Lemaire M, Steimer JL, Bruelisauer A, Niederberger W, Rowland M. Physiologically based pharmacokinetic study on a cyclosporin derivative, SDZ IMM 125. J Pharmacokinet Biopharm. 1994 Oct;22(5):327-65." />
+                    <Info min="0" max="1" flag="62" seq="38" ref="0" bb="32" group="64" />
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+                    <Info min="0" max="1000" flag="122" seq="64" ref="0" bb="32" group="92" />
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+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="64" ref="0" bb="32" group="95" />
+                  </Parameter>
+                  <Parameter id="CIWG9Sfj8kOV_ewWzlxfyg" name="fGFRpremat" description="Fractional offset in the GFR that corrects for a tendency to slightly underestimate the observed median GFR values in preterm infants below approximately 32 weeks of gestation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.258">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="27" source="Publication" description="Claassen K, Thelen K, Coboeken K, Gaub T, Lippert J, Allegaert K, Willmann S. Development of a Physiologically-Based Pharmacokinetic Model for Preterm Neonates: Evaluation with In Vivo Data. Current Pharmaceutical Design, 2015, 21, 5688-5698" />
+                    <Info min="0.258" max="0.258" flag="54" seq="99" ref="0" bb="32" group="30" />
+                  </Parameter>
+                  <DistributedParameter id="1ITrBksGlEyz8JGNZUK9xg" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="gekgB6uyoUeQgWIwjyFlZA" mode="Logical" isDefault="1" displayUnit="l">
+                    <Children>
+                      <Parameter id="emjflzKDOUi26CWEhqffzQ" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.503084571851831">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="65" />
+                      </Parameter>
+                      <Parameter id="BNHjGczMp0CwfW2DWzAMSQ" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.43771998528" displayUnit="l">
+                        <Info min="0" flag="34" seq="1" ref="0" bb="32" group="65" />
+                      </Parameter>
+                      <Parameter id="tnrEmkthikeiA062yOd64Q" name="Deviation" description="Standard deviation of Normal distribution" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.107804039048952" displayUnit="l">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="65" />
+                      </Parameter>
+                      <Container id="sxTojUXHFEaBgURJYJuz7A" name="Aciclovir" mode="Logical" containerType="Molecule" />
+                    </Children>
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
+                    <Info min="0" flag="106" seq="7" ref="0" bb="32" group="65" />
+                  </DistributedParameter>
+                  <DistributedParameter id="zXen_Fou2EChxKnBra4Dkg" name="Age of aging onset" description="Sets the start age for aging processes" persistable="0" isFixedValue="0" dim="Age in years" quantityType="Parameter" negativeValuesAllowed="1" formula="PfQ0-74r6kGt67gUYTQfqQ" mode="Logical" isDefault="1" displayUnit="year(s)">
+                    <Children>
+                      <Parameter id="5me68Mb0kUypJPczgFgBtw" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="30" />
+                      </Parameter>
+                      <Parameter id="kE_VQcNlPE2ey6L_BFz85Q" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Age in years" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="30" displayUnit="year(s)">
+                        <Info min="30" max="30" flag="50" seq="1" ref="0" bb="32" group="30" />
+                      </Parameter>
+                      <Container id="qadYvM-oaEecCz64Gj66JQ" name="Aciclovir" mode="Logical" containerType="Molecule" />
+                    </Children>
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="15" source="Publication" description="Schlender J-F, Meyer M, et al. Development of a Whole-Body Physiologically Based Pharmacokinetic Approach to Assess the Pharmacokinetics of Drugs in Elderly Individuals. Clinical Pharmacokinetics. 2016;55(12):1573-1589. doi:10.1007/s40262-016-0422-3" />
+                    <Info min="30" max="30" flag="54" seq="99" ref="0" bb="32" group="30" />
+                  </DistributedParameter>
+                  <DistributedParameter id="l89LmxA0tkeHv8CLbhVbQw" name="Aging half-time" description="Describes the age where the specific GFR reduction is half way decreased" persistable="0" isFixedValue="0" dim="Age in years" quantityType="Parameter" negativeValuesAllowed="1" formula="y2ZG0t5gokmVXp4mAWizHA" mode="Logical" isDefault="1" displayUnit="year(s)">
+                    <Children>
+                      <Parameter id="sIhOfzwWWECVlEsbeIvP9Q" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="30" />
+                      </Parameter>
+                      <Parameter id="AG_h6uB3j0yRpgM0q75dtQ" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Age in years" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="54" displayUnit="year(s)">
+                        <Info min="30" max="100" flag="50" seq="1" ref="0" bb="32" group="30" />
+                      </Parameter>
+                      <Container id="krxKHHnFvUy2AcE2BbA_OA" name="Aciclovir" mode="Logical" containerType="Molecule" />
+                    </Children>
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="15" source="Publication" description="Schlender J-F, Meyer M, et al. Development of a Whole-Body Physiologically Based Pharmacokinetic Approach to Assess the Pharmacokinetics of Drugs in Elderly Individuals. Clinical Pharmacokinetics. 2016;55(12):1573-1589. doi:10.1007/s40262-016-0422-3" />
+                    <Info min="30" max="100" flag="54" seq="99" ref="0" bb="32" group="30" />
+                  </DistributedParameter>
+                  <DistributedParameter id="VEUgRYcRckCXWIDMzkEQ2Q" name="GFRmat" description="Mature value for GFR in a healthy adult individual weighing 70 kg (=117 mL/min)" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="VN7KRqZ5lEiDELd5KQGpxQ" mode="Logical" isDefault="1" displayUnit="l/min">
+                    <Children>
+                      <Parameter id="VCpxzJTplU-eNeNkbpk-hA" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="30" />
+                      </Parameter>
+                      <Parameter id="HLLB3B9VAkS5h-dV0rWorg" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.11704" displayUnit="l/min">
+                        <Info min="0" flag="50" seq="1" ref="0" bb="32" group="30" />
+                      </Parameter>
+                      <Parameter id="ciD-J91ZvkaU4GQQ8ts-Aw" name="Deviation" description="Standard deviation of Normal distribution" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.026708" displayUnit="l/min">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="30" />
+                      </Parameter>
+                      <Container id="or3sJN2-K02EoEz45V9erA" name="Aciclovir" mode="Logical" containerType="Molecule" />
+                    </Children>
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="27" source="Publication" description="Claassen K, Thelen K, Coboeken K, Gaub T, Lippert J, Allegaert K, Willmann S. Development of a Physiologically-Based Pharmacokinetic Model for Preterm Neonates: Evaluation with In Vivo Data. Current Pharmaceutical Design, 2015, 21, 5688-5698" />
+                    <Info min="0" flag="54" seq="99" ref="0" bb="32" group="30" />
+                  </DistributedParameter>
+                  <DistributedParameter id="gUd5RR1Ack2cnNK2xzpQ-A" name="Hill coefficient for aging GFR" description="Parameter informing the exponential reduction of the aging GFR" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="SzifsOFZsEqAvixPCDTCbg" mode="Logical" isDefault="1">
+                    <Children>
+                      <Parameter id="zRA32RVb5EStbjXnsw7-Jw" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="30" />
+                      </Parameter>
+                      <Parameter id="6lY_yqo5bEOSmJEiPLWSpg" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.5">
+                        <Info min="0" flag="34" seq="1" ref="0" bb="32" group="30" />
+                      </Parameter>
+                      <Container id="DU_SfsE6YUKvbEXHyZOv4g" name="Aciclovir" mode="Logical" containerType="Molecule" />
+                    </Children>
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="15" source="Publication" description="Schlender J-F, Meyer M, et al. Development of a Whole-Body Physiologically Based Pharmacokinetic Approach to Assess the Pharmacokinetics of Drugs in Elderly Individuals. Clinical Pharmacokinetics. 2016;55(12):1573-1589. doi:10.1007/s40262-016-0422-3" />
+                    <Info min="0" flag="38" seq="99" ref="0" bb="32" group="30" />
+                  </DistributedParameter>
+                  <DistributedParameter id="cU6XGFXKS0CN3UrDDYweVw" name="Hill coefficient for GFR" description="Parameter describing the cooperativity of the process for GFR calculation" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="vKOIC6dtvE6yQTLqJ-eY9A" mode="Logical" isDefault="1">
+                    <Children>
+                      <Parameter id="X9RBKqiOh0-Jwx3RGhUCXA" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="30" />
+                      </Parameter>
+                      <Parameter id="skwaHNCGhkmY7IGpNjkQ-g" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="15">
+                        <Info min="1" flag="50" seq="1" ref="0" bb="32" group="30" />
+                      </Parameter>
+                      <Parameter id="TgE5c09svEu_QU_t6OjVDQ" name="Deviation" description="Standard deviation of Normal distribution" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.257">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="30" />
+                      </Parameter>
+                      <Container id="C9ifU9g1i0CKY4F5WkN0dg" name="Aciclovir" mode="Logical" containerType="Molecule" />
+                    </Children>
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="27" source="Publication" description="Claassen K, Thelen K, Coboeken K, Gaub T, Lippert J, Allegaert K, Willmann S. Development of a Physiologically-Based Pharmacokinetic Model for Preterm Neonates: Evaluation with In Vivo Data. Current Pharmaceutical Design, 2015, 21, 5688-5698" />
+                    <Info min="1" flag="54" seq="99" ref="0" bb="32" group="30" />
+                  </DistributedParameter>
+                  <DistributedParameter id="GQLeQMdp50uX8c4UKBR9sA" name="Maximal decreasing rate factor" description="Parameter describes the maximal decreasing rate per year of age" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ZG0xvNOXm06Nnzk38aA6cQ" mode="Logical" isDefault="1">
+                    <Children>
+                      <Parameter id="YSky5Z0hfE2UpAC_gDTaZw" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="30" />
+                      </Parameter>
+                      <Parameter id="p9jeNa8oU0u5a7vMvrsJOA" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.9">
+                        <Info min="0" flag="50" seq="1" ref="0" bb="32" group="30" />
+                      </Parameter>
+                      <Container id="_TXNLC2GzEqhZ_qe299PRA" name="Aciclovir" mode="Logical" containerType="Molecule" />
+                    </Children>
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="15" source="Publication" description="Schlender J-F, Meyer M, et al. Development of a Whole-Body Physiologically Based Pharmacokinetic Approach to Assess the Pharmacokinetics of Drugs in Elderly Individuals. Clinical Pharmacokinetics. 2016;55(12):1573-1589. doi:10.1007/s40262-016-0422-3" />
+                    <Info min="0" flag="54" seq="99" ref="0" bb="32" group="30" />
+                  </DistributedParameter>
+                  <DistributedParameter id="AW-molUPtUK-P9a5fojCpw" name="TM50 for GFR" description="TM50 for GFR calculation" persistable="0" isFixedValue="0" dim="Age in weeks" quantityType="Parameter" negativeValuesAllowed="1" formula="3CxzOHCYMU2nTlvKLp6rcQ" mode="Logical" isDefault="1" displayUnit="week(s)">
+                    <Children>
+                      <Parameter id="lM7Q9NevIkCJ61Zh84c1-w" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="30" />
+                      </Parameter>
+                      <Parameter id="CSBTpJAkB06FQXiiQ2T95g" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Age in weeks" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="44.4" displayUnit="week(s)">
+                        <Info min="1" flag="50" seq="1" ref="0" bb="32" group="30" />
+                      </Parameter>
+                      <Parameter id="Z9eGng7XhkumBTeGfp_hsg" name="Deviation" description="Standard deviation of Normal distribution" icon="Parameter" persistable="0" isFixedValue="0" dim="Age in weeks" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.04" displayUnit="week(s)">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="30" />
+                      </Parameter>
+                      <Container id="2lrkhnJJfkaQ5BjtXvpL-g" name="Aciclovir" mode="Logical" containerType="Molecule" />
+                    </Children>
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="27" source="Publication" description="Claassen K, Thelen K, Coboeken K, Gaub T, Lippert J, Allegaert K, Willmann S. Development of a Physiologically-Based Pharmacokinetic Model for Preterm Neonates: Evaluation with In Vivo Data. Current Pharmaceutical Design, 2015, 21, 5688-5698" />
+                    <Info min="1" flag="54" seq="99" ref="0" bb="32" group="30" />
+                  </DistributedParameter>
+                  <DistributedParameter id="B2nzuU_uS0OXn5iL-Nz5jw" name="Specific blood flow rate" description="Blood flow rate normalized to the organ volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" formula="cN1DBkrGOUq2D6R32DWBgw" mode="Logical" isDefault="1" displayUnit="ml/min/100g organ">
+                    <Children>
+                      <Parameter id="u9SZjrON80CQ3jKed5ZzLQ" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="5" />
+                      </Parameter>
+                      <Parameter id="5uQGGU2ExEGpOOI31Rymgg" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="3.02705" displayUnit="ml/min/100g organ">
+                        <Info min="0" flag="50" seq="1" ref="0" bb="32" group="5" />
+                      </Parameter>
+                      <Parameter id="nKbLwRXwi0yRLz5TvBdKhA" name="Deviation" description="Standard deviation of Normal distribution" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.1513525" displayUnit="ml/min/100g organ">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="5" />
+                      </Parameter>
+                      <Container id="SZBsEykpzUGavI4IsW9khQ" name="Aciclovir" mode="Logical" containerType="Molecule" />
+                    </Children>
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="40" source="Publication" description="Edginton, A.N., Schmitt, W. &amp; Willmann, S. Clin Pharmacokinet (2006) 45: 1013. https://doi.org/10.2165/00003088-200645100-00005" />
+                    <Info min="0" flag="122" seq="101" ref="0" bb="32" group="5" />
+                  </DistributedParameter>
+                  <Container id="5HBO78nMlkKNzLDJB1gD3w" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
+                    <Tags>
+                      <Tag value="Kidney" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="kGJIb9Aa3UGDbJOOQq7B-A" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="WiDWMA7xi02WdVvl1Rjr0g" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="NHBDLZB5T02sXhLjpBu1qw" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="yYX4DjDwkEOGUvd-DF06pA" isDefault="1" displayUnit="l">
+                        <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                        <Info min="0" flag="62" seq="12" ref="0" bb="2" group="126" />
+                      </Parameter>
+                      <MoleculeAmount id="6n1OnIkxGEeWoQxjI1QLyA" name="CYP344" icon="ENZYME" persistable="0" isFixedValue="0" dim="Amount" quantityType="Enzyme" negativeValuesAllowed="0" formula="rMXLZglcaUaofPZ0c6I6Yw" mode="Logical" scaleDivisor="1" displayUnit="µmol">
+                        <Children>
+                          <Parameter id="Naylzrc6eE-dc2p__aVq1A" name="Degradation coefficient" description="First order turnover rate constant of the enzyme" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="c2fNMePAyki4XPdR-AEHaQ" isDefault="1" displayUnit="1/min">
+                            <ValueOrigin id="33" source="Other" description="OSP Suite Manual Chapter 16. PK-Sim®- Compounds: Defining inhibition/induction processes" />
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="eitLWXLWcUaD1788sftitA" name="Relative expression" description="Relative expression" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="fqrxyq94VkWMTLJeRjjhEQ" isDefault="1">
+                            <Info min="0" flag="60" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="YBp-BsAyfUi1a67i_9SgZQ" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="YQ_SIzoIak2o9B3xCbLazA" isDefault="1">
+                            <Info min="0" flag="58" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="KtgeDyhfhkOkykC14Sj8Xg" name="Relative expression out." description="Relative Expression that will be used in the simulation" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="fbRCNZOks0i0JlaOaYnbvg" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="_euwIvs_m0W-8o-SJXuy-g" name="Start amount" description="Start amount of molecule" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" formula="EPX-QNxBZE2pcwiBNY6NfA" isDefault="1" displayUnit="µmol">
+                            <Info flag="54" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="OsootmoIOUuzjV7_sQNw6g" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="_5AQF4X5mkuTWnIB24ghvw" isDefault="1" displayUnit="µmol/l">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Parameter id="ADN8g5A16UO3PGHUMxB5RA" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="5aQ6x8PYhkWb54v9VifdRg" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                          </Parameter>
+                          <Parameter id="LPLhhCdktUyt31JumTKE1w" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="s-bBHNnsiUWRw-rY8F-WKg" isDefault="1" displayUnit="min">
+                            <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Observer id="wtBZpXTdwkaqAUEdRHk-7w" name="Concentration in container" description="Concentration of the molecule" icon="Observer" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Enzyme, Observer" negativeValuesAllowed="1" formula="6wCmGaSt3UirOnRpXv6unA" displayUnit="µmol/l" />
+                        </Children>
+                      </MoleculeAmount>
+                      <MoleculeAmount id="UIDahFhwD0qylCjxxmdl8g" name="Aciclovir" icon="DRUG" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" negativeValuesAllowed="0" mode="Logical" scaleDivisor="1" value="0" displayUnit="µmol">
+                        <Children>
+                          <Parameter id="qfzspXp2HUePsr-n_i8eCg" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="_5AQF4X5mkuTWnIB24ghvw" isDefault="1" displayUnit="µmol/l">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Parameter id="vzQlia-r8k2B1Rmof3ny6w" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="V-GqiQA_3U6N5EK1j7DL4A" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                          </Parameter>
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+                        <Info min="0" flag="34" seq="1" ref="0" bb="32" group="144" />
+                      </Parameter>
+                      <Parameter id="mKPV2Pk3JkSgbgRgGLxUdA" name="GeometricDeviation" description="Geometric standard deviation of LogNormal distribution" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.6">
+                        <Info min="1" flag="18" seq="1" ref="0" bb="32" group="144" />
+                      </Parameter>
+                    </Children>
+                    <Info min="0" flag="106" seq="1" ref="0" bb="32" group="144" />
+                  </DistributedParameter>
+                  <Container id="YK1AJzgljEe91cerAd5phA" name="Stomach" description="Stomach" icon="Stomach" mode="Physical" containerType="Compartment">
+                    <Tags>
+                      <Tag value="Lumen" />
+                      <Tag value="LumenSegment" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="dN5G2SgsqkGgoLIj_neiHw" name="Absorption of liquid" description="rate of liquid outflow" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0" displayUnit="1/min">
+                        <Info flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="TvlnRLWHYE2Krq_z2k2z5A" name="FillLevelFlag" description="Fill Level Flag" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="GLqHpG_OJkWM8l0SHiAa5g" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="ziJD2xNenEGFNyDuY3aUdw" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="aVy7eAeHjE6ETh8kdqeSuQ" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="g0cK7Vyw40mNEx6DQzjvxg" name="Geometric surface area" description="Geometric surface area of GI segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="wsKEN3Lx60Ku0hovyuGDqw" isDefault="1" displayUnit="cm²">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="62" seq="1" ref="0" bb="32" group="33" />
+                      </Parameter>
+                      <Parameter id="Ckvgf0Z5fkKPmQtgR5SNiw" name="GET of non-disintegrated moiety" description="The time point at which a solid dosage leaves the stomach and enters the duodenum. Please note that the discrete emptying of a solid dosage form depends on both the physiological properties of the individual and the dosage form." icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="60" displayUnit="min">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="39" />
+                      </Parameter>
+                      <Parameter id="M6z0-t3kxk-XKcMe9ZB6rw" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="A2SEF9y0Z06oVaY0rNsZFw" isDefault="1" displayUnit="1/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="TW1bK6ubi0mHKXfkMh4I-w" name="Liquid" description="Liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="DxFS8aU9SUGHF72wLzZs7A" isDefault="1" rHSFormula="J9AQfVrFVk2cgWYcpBeayg" displayUnit="l">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="siuFTdDnEk678u3daRvL-g" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="4DtEkIz8Dk6PidOTBqksiQ" isDefault="1" displayUnit="l/min">
+                        <Info flag="52" seq="1" ref="0" bb="2" group="39" />
+                      </Parameter>
+                      <Parameter id="ZKzM5W3TQka70tUwUt8r-A" name="pH" description="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="u2iUP5GPYk2OdxHjCTuLCA" isDefault="1">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" max="14" flag="52" seq="1" ref="0" bb="32" group="41" />
+                      </Parameter>
+                      <Parameter id="4pdlLjyDGkKM_uAx1H_0AQ" name="Secretion of liquid" description="Rate of liquid inflow" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Q34W-betKEKw7IEFDNesew" isDefault="1" displayUnit="l/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="w1i1PGu-yEaAMPl8GnWGTA" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="v0bWMujBVUKTXasj7lfskg" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="62" seq="1" ref="0" bb="2" group="56" />
+                      </Parameter>
+                      <Parameter id="a82cJC15kEyFkBPmsu6JYg" name="Volume (gut wall)" description="Volume of the gut wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="IXYNaK4GrUWeQymyVXetxg" isDefault="1" displayUnit="l">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="62" seq="1" ref="0" bb="32" group="44" />
+                      </Parameter>
+                      <Parameter id="jPNLnJjVBUm8Br9nC4q4yQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="WiDWMA7xi02WdVvl1Rjr0g" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="ALRspI30Qk-iBp7cvuJ5Jg" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.030169">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="58" seq="1" ref="0" bb="32" group="43" />
+                      </Parameter>
+                      <Parameter id="6qXkM6TpOEy3neq7U7sdVQ" name="pH in fed state" description="pH in fed state" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="5.5">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" max="14" flag="52" seq="1" ref="0" bb="32" group="41" />
+                      </Parameter>
+                      <Parameter id="HFIKsjqEWkSmnfsG7hLw7Q" name="Thickness of gut wall" description="Thickness of Gut Wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.022668" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="54" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <Parameter id="FVN0whlnl0iBpblxRj1G4w" name="Inverse rate of inflow of liquid into stomach" description="Inverse rate of inflow of liquid into stomach" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="15" displayUnit="min">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="1" max="10000" flag="54" seq="1" ref="0" bb="32" group="46" />
+                      </Parameter>
+                      <Parameter id="JiUOaQI9BU6yvjPSBPz_jw" name="pH in fasted state" description="pH in fasted state" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <ValueOrigin id="25" source="Publication" description="Stefan Willmann, Walter Schmitt,Jörg Keldenich, Jörg Lippert, and Jennifer B. Dressman: A Physiological Model for the Estimation of the Fraction Dose Absorbed in Humans. J. Med. Chem. 2004, 47, 4022-4031" />
+                        <Info min="0" max="14" flag="122" seq="1" ref="0" bb="32" group="41" />
+                      </Parameter>
+                      <DistributedParameter id="hybLErQKUUewxmdCYKxc0w" name="Distal radius" description="Distal radius of intestinal segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="Ipkt0lQPDEmci5khHMXzQg" mode="Logical" isDefault="1" displayUnit="cm">
+                        <Children>
+                          <Parameter id="NyLWLoV4NEmA_fs7JtBWXA" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="32" group="35" />
+                          </Parameter>
+                          <Parameter id="sCVY5mbO1USpnDWlTqjTDg" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5" displayUnit="cm">
+                            <Info min="0" flag="50" seq="1" ref="0" bb="32" group="35" />
+                          </Parameter>
+                          <Container id="iCIJ9OpWZE-txDeLjwfZQw" name="Aciclovir" mode="Logical" containerType="Molecule" />
+                        </Children>
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="122" seq="1" ref="0" bb="32" group="35" />
+                      </DistributedParameter>
+                      <DistributedParameter id="evG6jiJe8UuqJUBI3lnqnQ" name="Gastric emptying time" description="The time at which the (1-1/e)th part (approximately 63%) of the applied dose (fasted state) is released from the stomach into the duodenum according to a first order process. Please note that in the case that a meal is co-administered with the drug, the gastric emptying rate is described using a Weibull function. The parameters of the Weibull function and, thus, the gastric emptying time, then depend on the volume and composition of the meal" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="ttg-gOTex0GeHGDaggzexA" mode="Logical" isDefault="1" displayUnit="min">
+                        <Children>
+                          <Parameter id="0-mlVN4yZUaLU9qPYM1vRQ" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="32" group="46" />
+                          </Parameter>
+                          <Parameter id="y0q1N5c6K0itD_XvgB37aw" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="15" displayUnit="min">
+                            <Info min="1" max="10000" flag="50" seq="1" ref="0" bb="32" group="46" />
+                          </Parameter>
+                          <Parameter id="atYymibMLUC0PAyw5kp11Q" name="GeometricDeviation" description="Geometric standard deviation of LogNormal distribution" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.6">
+                            <Info min="1" flag="18" seq="1" ref="0" bb="32" group="46" />
+                          </Parameter>
+                          <Container id="zF23IzdI1UO6F2PlyyCvYA" name="Aciclovir" mode="Logical" containerType="Molecule" />
+                        </Children>
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="1" max="10000" flag="122" seq="1" ref="0" bb="32" group="46" />
+                      </DistributedParameter>
+                      <DistributedParameter id="mo9PtThjGUurQNpgYOPVnA" name="GET_alpha (Weibull function) variability factor" description="GET_alpha (Weibull function) variability factor" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="aLUpPZ3BRE6e08wzZFlB8g" mode="Logical" isDefault="1">
+                        <Children>
+                          <Parameter id="tvamDemflUmby-symB9PXw" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="32" group="46" />
+                          </Parameter>
+                          <Parameter id="U1zFjC6HMEeL_e9AVBkmLQ" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                            <Info min="0" flag="34" seq="1" ref="0" bb="32" group="46" />
+                          </Parameter>
+                          <Parameter id="xyWFsIqWuECLG715v6gD3Q" name="GeometricDeviation" description="Geometric standard deviation of LogNormal distribution" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.74">
+                            <Info min="1" flag="18" seq="1" ref="0" bb="32" group="46" />
+                          </Parameter>
+                          <Container id="e42WC60qtEiDwoY-FiTI8A" name="Aciclovir" mode="Logical" containerType="Molecule" />
+                        </Children>
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="38" seq="1" ref="0" bb="32" group="46" />
+                      </DistributedParameter>
+                      <DistributedParameter id="dd5l8eyrfk2uWI9uV3HtgQ" name="GET_beta (Weibull function) variability factor" description="GET_beta (Weibull function) variability factor" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="QYW3xXRwKU-WSpfab20HDg" mode="Logical" isDefault="1">
+                        <Children>
+                          <Parameter id="i3VaKnLwoU-QbYqd9zbR0A" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="32" group="46" />
+                          </Parameter>
+                          <Parameter id="EbCpvx0FKEypf9Js3S1Pdg" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                            <Info min="0" flag="34" seq="1" ref="0" bb="32" group="46" />
+                          </Parameter>
+                          <Parameter id="9YorGkwPd02wNg4VGKVOnQ" name="GeometricDeviation" description="Geometric standard deviation of LogNormal distribution" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.32">
+                            <Info min="1" flag="18" seq="1" ref="0" bb="32" group="46" />
+                          </Parameter>
+                          <Container id="ryPlS4fof0KoE1Hf5RTtsA" name="Aciclovir" mode="Logical" containerType="Molecule" />
+                        </Children>
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="38" seq="1" ref="0" bb="32" group="46" />
+                      </DistributedParameter>
+                      <DistributedParameter id="sZeAU9CbA06uuVCqkxMRow" name="Length" description="Length" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="3mzO1KC_dk2uolj7lgc_YA" mode="Logical" isDefault="1" displayUnit="cm">
+                        <Children>
+                          <Parameter id="ZpJ-MArT3UqgKIaA39yWXQ" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="32" group="34" />
+                          </Parameter>
+                          <Parameter id="ocACeKZd2k-7mdsucIp0Ag" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2" displayUnit="cm">
+                            <Info min="0" flag="50" seq="1" ref="0" bb="32" group="34" />
+                          </Parameter>
+                          <Container id="_sIWmohVF0WUTacGOF9ojQ" name="Aciclovir" mode="Logical" containerType="Molecule" />
+                        </Children>
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="122" seq="1" ref="0" bb="32" group="34" />
+                      </DistributedParameter>
+                      <DistributedParameter id="MNa5p4GPqUKnIHlLgkVCMQ" name="Proximal radius" description="Proximal radius of intestinal segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="fCgtvW0Fm06imgrprDAjHQ" mode="Logical" isDefault="1" displayUnit="cm">
+                        <Children>
+                          <Parameter id="XFZHmrWWfEmS_IYd6lXLcQ" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="32" group="35" />
+                          </Parameter>
+                          <Parameter id="YW2_KYMtNEyyqyIoCBCWsw" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5" displayUnit="cm">
+                            <Info min="0" flag="50" seq="1" ref="0" bb="32" group="35" />
+                          </Parameter>
+                          <Container id="X0NBC-tjhESi5_SsIv8SfA" name="Aciclovir" mode="Logical" containerType="Molecule" />
+                        </Children>
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="122" seq="1" ref="0" bb="32" group="35" />
+                      </DistributedParameter>
+                      <MoleculeAmount id="N37e80oieUO_KxspDFVAFQ" name="CYP344" icon="ENZYME" persistable="0" isFixedValue="0" dim="Amount" quantityType="Enzyme" negativeValuesAllowed="0" formula="rMXLZglcaUaofPZ0c6I6Yw" mode="Logical" scaleDivisor="1" displayUnit="µmol">
+                        <Children>
+                          <Parameter id="vCFKYbdfpkW6PtqfVbb3tA" name="Degradation coefficient" description="First order turnover rate constant of the enzyme" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="c2fNMePAyki4XPdR-AEHaQ" isDefault="1" displayUnit="1/min">
+                            <ValueOrigin id="33" source="Other" description="OSP Suite Manual Chapter 16. PK-Sim®- Compounds: Defining inhibition/induction processes" />
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="W5wmxSfGO0eK5ZgX6ym80A" name="Relative expression" description="Relative expression" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0">
+                            <Info min="0" flag="60" seq="1" ref="0" bb="32" group="91" />
+                          </Parameter>
+                          <Parameter id="IZmD4sQrzUqjIeIUQiUy-A" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0">
+                            <Info min="0" flag="58" seq="1" ref="0" bb="32" group="91" />
+                          </Parameter>
+                          <Parameter id="ajwnw0gHNk2NNnFVIM5HQQ" name="Relative expression out." description="Relative Expression that will be used in the simulation" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="fbRCNZOks0i0JlaOaYnbvg" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="DwLUENSL6ECJjmdOFZgDKw" name="Start amount" description="Start amount of molecule" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" formula="EPX-QNxBZE2pcwiBNY6NfA" isDefault="1" displayUnit="µmol">
+                            <Info flag="54" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="9uicbwtbvUyq8b5KtHR_lg" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="_5AQF4X5mkuTWnIB24ghvw" isDefault="1" displayUnit="µmol/l">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Parameter id="30SOWRoo10mpoSzAX3SnYg" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="U_2ctnLfeE2XL7M5HfNbtw" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                          </Parameter>
+                          <Parameter id="Rz6HimYbAE2ViFt-7GaXqw" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="NWT1eET6MUme05UVv8nc5A" isDefault="1" displayUnit="min">
+                            <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                        </Children>
+                      </MoleculeAmount>
+                      <MoleculeAmount id="4PpwVZlVAkOcD3Z34R328w" name="Aciclovir" icon="DRUG" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" negativeValuesAllowed="0" mode="Logical" scaleDivisor="1" value="0" displayUnit="µmol">
+                        <Children>
+                          <Parameter id="-5jI6gpJv02jv-BMlAehLg" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="_5AQF4X5mkuTWnIB24ghvw" isDefault="1" displayUnit="µmol/l">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Parameter id="rumY3qg8kEKXNWfCzjMXiQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                          </Parameter>
+                          <Parameter id="oO6kYTxw-0Wr8Ff4QSlgBw" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="hFhZq990KkC5jRbjSWDCNg" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="AJMlMmZeBEKmrLR7xlNrfw" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="jvtdleEdNkWyWFij45BJFg" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="1JazMTVRjkS00NBv2wu4Kw" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ZVZF_QoUWE2wBBbAG2Uf-w" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="r_bjni9oL0CVbMJP42r5SQ" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="8yiMQwv9hkuSoj7akaIp9Q" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="L6i-1_sWdk2rxZXGFvvhPw" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Hp1he6MgYEyhbeCBcoobmQ" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="i2Z3eEuPX02OaTwnjD8MMw" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="R1Id7-mCqECMoSQ8ojHymw" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="_bhW7AgCuUey2uzHO7CFmQ" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Y94riZTQPUacfJA8HNhi0A" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="FzsjtolhlUCUSsdPfCjyzg" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ePIqU3hjRUGDx2yYy-9w9w" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="gC1376m0tU2YR6i9279t4Q" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="gY8KimgHVE64_M08HbWAQQ" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="CAQlygHFx0SrUl_1Pip3rw" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="NAd3FXobJkONp8yexFdL4Q" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="sYdHJb7SZk2ZVnHMpiqw_A" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="oSwggO4dq0-2q6RzoUWtZA" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="9F-siDM7AU2-NBMNZNRYBw" name="Solubility" description="Solubility" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="YqR2OF7FaE-5GYOnyAIbAw" isDefault="1" displayUnit="mg/l">
+                            <Info min="0" flag="122" seq="1" ref="0" bb="2" group="42" />
+                          </Parameter>
+                          <Parameter id="qdY-_r0N6UuG9lq1tYQePg" name="Solubility table" description="Solubility table" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="c48WiT2Pc0Gh1iOAm-6w-Q" isDefault="1" displayUnit="mg/l">
+                            <Info min="0" flag="50" seq="1" ref="0" bb="2" group="42" />
+                          </Parameter>
+                          <Parameter id="ti3f0EYOfU6wWVlGzuvHKA" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="HHHE_dtP_U6wK8Ik-gPBIg" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="0l_YJ4aH9UK2bDrV1QYC9g" name="Effective concentration in lumen" description="In case of supersaturation: molecule amount divided by liquid volume. Otherwise: Min(intestinal solubility; molecule amount divided by liquid volume)." icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="V_VJE9J6HUOBXiFqWyGbAQ" isDefault="1" displayUnit="µmol/l">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="42" />
+                          </Parameter>
+                          <Observer id="8GWb8ccEckyCNqNyxFCW2A" name="Concentration in lumen" description="Concentration of the molecule in lumen" icon="Observer" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" negativeValuesAllowed="1" formula="SEsNpt8BTUG8roHXWpFOQA" displayUnit="µmol/l" />
+                        </Children>
+                      </MoleculeAmount>
+                    </Children>
+                  </Container>
+                  <Container id="FiXHspIznEeQWrX1VkMsyg" name="Duodenum" description="Duodenum" icon="Duodenum" mode="Physical" containerType="Compartment">
+                    <Tags>
+                      <Tag value="Lumen" />
+                      <Tag value="LumenSegment" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="xBFwEiuwRk-TxOzkocy4hA" name="Absorption of liquid" description="rate of liquid outflow" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="UmMKT-hULkiERHGJMVLGUw" isDefault="1" displayUnit="1/min">
+                        <Info flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="I7w4T-omMk2ZO4kUfGzItg" name="Distal radius" description="Distal radius of intestinal segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="qN0sQEkpKUSNvqPOFISgPQ" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="4AdG_Y8M_kCzWs0mw8YyUw" name="Effective surface area" description="Effective surface area of GI segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="UDKQRMZb0kGECYiG1jVLSA" isDefault="1" displayUnit="cm²">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
+                        <Info min="0" flag="52" seq="1" ref="0" bb="32" group="33" />
+                      </Parameter>
+                      <Parameter id="73KCHYT4hEiN1e88Lzfm_g" name="FillLevelFlag" description="Fill Level Flag" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="GLqHpG_OJkWM8l0SHiAa5g" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="nrwTNmFIq0eGQOYzxtsnJA" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="aVy7eAeHjE6ETh8kdqeSuQ" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="Hqw9GnRefUqkgoyoyxW0tQ" name="Geometric surface area" description="Geometric surface area of GI segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="wsKEN3Lx60Ku0hovyuGDqw" isDefault="1" displayUnit="cm²">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="62" seq="1" ref="0" bb="32" group="33" />
+                      </Parameter>
+                      <Parameter id="cdN3-6XkeEm9Tk3i6WbjEw" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="o1djuFo6TEmrDhN8sk34xQ" isDefault="1" displayUnit="1/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="Zmrdz5--L0SJHFRtRG19YA" name="Length" description="Length" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="sIXkaS02_UGII5sFXg9TKg" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="106" seq="1" ref="0" bb="32" group="34" />
+                      </Parameter>
+                      <Parameter id="jhODYVOTAUyPwN64_L9u0A" name="Liquid" description="Liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="DxFS8aU9SUGHF72wLzZs7A" isDefault="1" rHSFormula="T8GtO-LXJ0OBLe0X01njkg" displayUnit="l">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="JOAKIE8gtESRNXFyqNwpNw" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="DPN7hsoR10mEgAQWjEMIDg" isDefault="1" displayUnit="l/min">
+                        <Info flag="52" seq="1" ref="0" bb="2" group="39" />
+                      </Parameter>
+                      <Parameter id="aexqgUMsoEG74Jc7TuuDhA" name="Proximal radius" description="Proximal radius of intestinal segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="FyJ0mmQ3tkGYaA3eL3fCSg" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="p3mZOgyK1U2NaT8vMrlGnQ" name="Secretion of liquid" description="Rate of liquid inflow" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="qD0Mle0pZkiYQ7ZcXu9m0A" isDefault="1" displayUnit="l/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="xvWQ8c73VEy8uN9ny68KMw" name="Thickness of gut wall" description="Thickness of Gut Wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="JHk9xtQ6YUWAs-vav0AWPg" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="38" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <Parameter id="EtvIHkYe20es2JwfU2uRmg" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="v0bWMujBVUKTXasj7lfskg" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="62" seq="1" ref="0" bb="2" group="56" />
+                      </Parameter>
+                      <Parameter id="udv1W6xWKk24piMe2zzg8w" name="Volume (gut wall)" description="Volume of the gut wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="WQ3NHX0mS0mlEFE2hJNOUQ" isDefault="1" displayUnit="l">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="62" seq="1" ref="0" bb="32" group="44" />
+                      </Parameter>
+                      <Parameter id="lf4_VlppD0SSDh_jeXXvJQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="WiDWMA7xi02WdVvl1Rjr0g" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="ez_yUeHXWUKxdDXeIpWjdA" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.06">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="58" seq="1" ref="0" bb="32" group="43" />
+                      </Parameter>
+                      <Parameter id="F8vK5pdG4UScJzC9-s11zg" name="Intestinal transit rate" description="Transit rate along intestinal segments" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="116" displayUnit="1/min">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="54" seq="1" ref="0" bb="32" group="46" />
+                      </Parameter>
+                      <Parameter id="m34UADozwkC5IoxAf2Q7hA" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0289872252" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="34" />
+                      </Parameter>
+                      <Parameter id="hgSidqQl1UmwqcWao6g_Kg" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.129622362">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="34" />
+                      </Parameter>
+                      <Parameter id="VgKs77j7iUismffrLPtMwQ" name="Microvilli factor" description="Microvilli factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="25">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="38" seq="1" ref="0" bb="32" group="33" />
+                      </Parameter>
+                      <Parameter id="f_SzF1nyn0OyII5YxxBAvw" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.002264627" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="3_meRRwCe0mdBzBDppESHA" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.010126747">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="xJDIhh8cWES_Cb5O7sk6_Q" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0020705161" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="5ITEdX30wkCrimpgIjvVGg" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.00925874">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="bkbJpl6RCUqdQCGjWZ6_tQ" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0186500479" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <Parameter id="pReAA_FI5UmH6lny8clpbg" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0441002752" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <Parameter id="O5Q6rQiPykuny0gs2GbCsQ" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.30705627" displayUnit="1/cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <Parameter id="621M2BxtpUSt4uZDF-8M_Q" name="pH" description="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="6">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
+                        <Info min="0" max="14" flag="122" seq="1" ref="0" bb="32" group="41" />
+                      </Parameter>
+                      <DistributedParameter id="d_kc-wQKGUeDJd0amhQdoA" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="dFo_ZOEzykaIAMuTgFnjtw" mode="Logical" isDefault="1">
+                        <Children>
+                          <Parameter id="_xYhpH-GRU-Yw48BHSge7Q" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="32" group="32" />
+                          </Parameter>
+                          <Parameter id="fVU9VAnpcEyJNErRZtR-eg" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="292.6883">
+                            <Info min="0" flag="50" seq="1" ref="0" bb="32" group="32" />
+                          </Parameter>
+                          <Container id="Ro7X0pVFZUWbP9OZxXynzA" name="Aciclovir" mode="Logical" containerType="Molecule" />
+                        </Children>
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="122" seq="1" ref="0" bb="32" group="32" />
+                      </DistributedParameter>
+                      <MoleculeAmount id="g91uBoU8QEy3IjuNcDvyvA" name="CYP344" icon="ENZYME" persistable="0" isFixedValue="0" dim="Amount" quantityType="Enzyme" negativeValuesAllowed="0" formula="rMXLZglcaUaofPZ0c6I6Yw" mode="Logical" scaleDivisor="1" displayUnit="µmol">
+                        <Children>
+                          <Parameter id="VtDvqmtiHUOJSyBF-nA_0A" name="Degradation coefficient" description="First order turnover rate constant of the enzyme" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="c2fNMePAyki4XPdR-AEHaQ" isDefault="1" displayUnit="1/min">
+                            <ValueOrigin id="33" source="Other" description="OSP Suite Manual Chapter 16. PK-Sim®- Compounds: Defining inhibition/induction processes" />
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="zMV0G2fC00umN-dm18_LJg" name="Relative expression" description="Relative expression" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0">
+                            <Info min="0" flag="60" seq="1" ref="0" bb="32" group="91" />
+                          </Parameter>
+                          <Parameter id="YtpXWpxBsEiAVjDLgep6eA" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0">
+                            <Info min="0" flag="58" seq="1" ref="0" bb="32" group="91" />
+                          </Parameter>
+                          <Parameter id="Amjju3PeTk-jiIS0wLk3dQ" name="Relative expression out." description="Relative Expression that will be used in the simulation" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="fbRCNZOks0i0JlaOaYnbvg" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="Ul6VwJWFZEGE2RKpZHyoQQ" name="Start amount" description="Start amount of molecule" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" formula="EPX-QNxBZE2pcwiBNY6NfA" isDefault="1" displayUnit="µmol">
+                            <Info flag="54" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="58FcPQyiT0m3S-B3xV8T_Q" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="_5AQF4X5mkuTWnIB24ghvw" isDefault="1" displayUnit="µmol/l">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Parameter id="NioxDhT8Mke1vjYDAURT6Q" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="yTvsKm4FhkO7sNFUuBvZVA" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                          </Parameter>
+                          <Parameter id="LMwbDTiFfECBQC2BLZuzBg" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="pFEyyrBeEEepmgg-nbccKQ" isDefault="1" displayUnit="min">
+                            <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                        </Children>
+                      </MoleculeAmount>
+                      <MoleculeAmount id="QIs0jmUAIE6ikShycjAOCw" name="Aciclovir" icon="DRUG" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" negativeValuesAllowed="0" mode="Logical" scaleDivisor="1" value="0" displayUnit="µmol">
+                        <Children>
+                          <Parameter id="5YYFTmpMEkil94V6MX5q1A" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="_5AQF4X5mkuTWnIB24ghvw" isDefault="1" displayUnit="µmol/l">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Parameter id="cmxNlEUqNkWjwPKR-1MxmQ" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" rHSFormula="OSfgBAXnF0aNkHHm7fg70A" value="0" displayUnit="µmol">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Parameter id="flBJJBlF5kWSMWOQxOZUVA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                          </Parameter>
+                          <Parameter id="eVLZKHZnN0ye_CdCg10vjw" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="JVwtt9G2m0uTwgYQqK8jvQ" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="mmEI5Vm_7EyygEC7ZU3qpg" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="zdl5XfHBTkq9CQMgyLpomA" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="GbjWxdP9Ckyac8fPx_m6dw" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ORl2tv-drEmYpLOHGxJBtw" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="w9LjHN2sB0uRQtEIkm1UdA" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="17CGeean50qxh1r1CfipcQ" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="T2-HLS0q-k26kbl8_B4NGg" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Q2b_mwN2okSBOt5MUJJ2WQ" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="017sdM7KNEeg8ui-lH-cfQ" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="YJrykU5DK0eFWFLJ1d0d6A" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="KTlIUkZXBEO9NOybWaPMug" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="4E1Pd6HWSkGPty3vI_2uJA" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="r1dWMUz3T0S3ZwLk8tTYGw" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="l6pn4b-B_EmZxXLTykiy2A" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="HfjBFcEihku9vi92kyOdww" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="RodTvk8gpkCiVYNQh3N4uA" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="IlFRX2sY4U6GgZmWQYmEEA" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IhoCYsVCz0WJl50ZEXbFLQ" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="QYA4q8A-YkKFyGn8ZVxmbw" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="QxIccaIqIUWxLCp4MegwrA" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="8AkMLTQJoUienEhFpDu7nQ" name="Solubility" description="Solubility" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="443d-A2UrUWdoYRsYbsLHA" isDefault="1" displayUnit="mg/l">
+                            <Info min="0" flag="122" seq="1" ref="0" bb="2" group="42" />
+                          </Parameter>
+                          <Parameter id="kqieeJ4fs0K7KkBxg9xQ-w" name="Solubility table" description="Solubility table" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="5cP6xEd9e0e2yKL-QW1aYg" isDefault="1" displayUnit="mg/l">
+                            <Info min="0" flag="50" seq="1" ref="0" bb="2" group="42" />
+                          </Parameter>
+                          <Parameter id="F4oBPo9YAEi3UvSGeIIvog" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="3GEoMcCAyEW4xr5tUS4T6Q" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="_x2lX_1tAEeY-VZrllk9Jw" name="Effective concentration in lumen" description="In case of supersaturation: molecule amount divided by liquid volume. Otherwise: Min(intestinal solubility; molecule amount divided by liquid volume)." icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="iukdTo7-LEKnRxXpguGZyQ" isDefault="1" displayUnit="µmol/l">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="42" />
+                          </Parameter>
+                          <Observer id="WDRlkZb-XUG3cGWI3PKz_w" name="Concentration in lumen" description="Concentration of the molecule in lumen" icon="Observer" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" negativeValuesAllowed="1" formula="SEsNpt8BTUG8roHXWpFOQA" displayUnit="µmol/l" />
+                          <Observer id="cZZ_uceBmkCBtKZcG-fI-w" name="Fraction of oral drug mass absorbed into mucosa segment" description="Fraction of oral drug mass absorbed into mucosa segment" icon="Observer" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Drug, Observer" negativeValuesAllowed="1" formula="r43vCSc7BEe5-dGA5yh3BA" />
+                        </Children>
+                      </MoleculeAmount>
+                    </Children>
+                  </Container>
+                  <Container id="Al-BX9A42kuv1-su9wdy3g" name="UpperJejunum" description="Upper Jejunum" icon="UpperJejunum" mode="Physical" containerType="Compartment">
+                    <Tags>
+                      <Tag value="Lumen" />
+                      <Tag value="LumenSegment" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="4mEXo6ql90GmodXVguG-fw" name="Absorption of liquid" description="rate of liquid outflow" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="O4fenhsNREiETfyYYeHK5w" isDefault="1" displayUnit="1/min">
+                        <Info flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="4FtPRfonZk2r6Cl2BbErmw" name="Distal radius" description="Distal radius of intestinal segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="qN0sQEkpKUSNvqPOFISgPQ" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="KvDAM78IDEutOZjLp4D9hA" name="Effective surface area" description="Effective surface area of GI segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="UDKQRMZb0kGECYiG1jVLSA" isDefault="1" displayUnit="cm²">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
+                        <Info min="0" flag="52" seq="1" ref="0" bb="32" group="33" />
+                      </Parameter>
+                      <Parameter id="23zP2oGaq0SDsYNClelrFQ" name="FillLevelFlag" description="Fill Level Flag" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="GLqHpG_OJkWM8l0SHiAa5g" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="GHIf2daitk-JkYegXcFLdA" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="aVy7eAeHjE6ETh8kdqeSuQ" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="4OTc55Oym0Oy7NwXWT31-g" name="Geometric surface area" description="Geometric surface area of GI segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="wsKEN3Lx60Ku0hovyuGDqw" isDefault="1" displayUnit="cm²">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="62" seq="1" ref="0" bb="32" group="33" />
+                      </Parameter>
+                      <Parameter id="9CnKVLD-FEqSbDTnf9Ir7g" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="pu5iMLcODU2s5O_R0veZew" isDefault="1" displayUnit="1/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="0lFxoTOc7EGIroyesyoPGQ" name="Length" description="Length" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="sIXkaS02_UGII5sFXg9TKg" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="106" seq="1" ref="0" bb="32" group="34" />
+                      </Parameter>
+                      <Parameter id="eIiTeWttw0WOnXdY3d_SUA" name="Liquid" description="Liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="DxFS8aU9SUGHF72wLzZs7A" isDefault="1" rHSFormula="dGV3zVh2jkeI8gfEEV1PIQ" displayUnit="l">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="WD5YuCrM9ECgYr5_smnI7Q" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="wmr3GBYQvka2nm0TyTBSLA" isDefault="1" displayUnit="l/min">
+                        <Info flag="52" seq="1" ref="0" bb="2" group="39" />
+                      </Parameter>
+                      <Parameter id="VcApubyUYkqhIiw0lkPOEA" name="Proximal radius" description="Proximal radius of intestinal segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="FyJ0mmQ3tkGYaA3eL3fCSg" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="5TW_lG5kC0ue7VJvtTooIQ" name="Secretion of liquid" description="Rate of liquid inflow" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="j4KjV3upC0qkomcgE_hlbA" isDefault="1" displayUnit="l/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="SWFAyxl8lEegf7moUtJg9g" name="Thickness of gut wall" description="Thickness of Gut Wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="JHk9xtQ6YUWAs-vav0AWPg" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="38" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <Parameter id="ycqMDZ_ngkO5-WDARkV8kg" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="v0bWMujBVUKTXasj7lfskg" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="62" seq="1" ref="0" bb="2" group="56" />
+                      </Parameter>
+                      <Parameter id="6ncN8uhcTkyHsj2soKVFuQ" name="Volume (gut wall)" description="Volume of the gut wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="p711jdid_0eQKuiMGZ5a4A" isDefault="1" displayUnit="l">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="62" seq="1" ref="0" bb="32" group="44" />
+                      </Parameter>
+                      <Parameter id="atLB5C_yPU2FfMbBxRPd0A" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="WiDWMA7xi02WdVvl1Rjr0g" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="qz9zVEAcpk6VIxWbwG8j5g" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.064841">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="58" seq="1" ref="0" bb="32" group="43" />
+                      </Parameter>
+                      <Parameter id="vbNh8-ueS0aL9sQ5bnjp3A" name="Intestinal transit rate" description="Transit rate along intestinal segments" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="5.0162" displayUnit="1/min">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="54" seq="1" ref="0" bb="32" group="46" />
+                      </Parameter>
+                      <Parameter id="jE2Yb1H4LkayYFkcvgPFaQ" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0670329582" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="34" />
+                      </Parameter>
+                      <Parameter id="yFXbZuz670aLEup-LUMaCQ" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.299751712">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="34" />
+                      </Parameter>
+                      <Parameter id="-0SFAoJ-x022WrAwrS4qoQ" name="Microvilli factor" description="Microvilli factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="25">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="38" seq="1" ref="0" bb="32" group="33" />
+                      </Parameter>
+                      <Parameter id="lmssGl2cr0SSXymS-9h0fg" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0020705161" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="4pTABti30kiB6ZL0y9mhsw" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.00925874">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="PcTFCUhO7EOgpCOyPnzhjQ" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0019411088" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="tCspFUCI7Ei2blRJ_LP5Jg" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.008680069">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="HG_Hhrw_eUC8oIyUygfw8Q" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.024936327" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <Parameter id="7_jYaoZdvU6YvXuUfpJ-YQ" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0589752766" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <Parameter id="Dr6QJhRI40ygDJXB3jK9Vw" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.30703115" displayUnit="1/cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <Parameter id="APYGjaC380qHXYVRP0bOtg" name="pH" description="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="6.25">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
+                        <Info min="0" max="14" flag="122" seq="1" ref="0" bb="32" group="41" />
+                      </Parameter>
+                      <DistributedParameter id="qSaxFUycC0KqK2GkuRc91A" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="z0cON8v5-06AiYwVJQfecg" mode="Logical" isDefault="1">
+                        <Children>
+                          <Parameter id="7iQ5nRO7U0OVotcvnHVrzw" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="32" group="32" />
+                          </Parameter>
+                          <Parameter id="Jql7Ox8s-0aKADKXg2Df6Q" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="447.9877">
+                            <Info min="0" flag="50" seq="1" ref="0" bb="32" group="32" />
+                          </Parameter>
+                          <Container id="hEmNUPwjq0OBljBSe0GGYQ" name="Aciclovir" mode="Logical" containerType="Molecule" />
+                        </Children>
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="122" seq="1" ref="0" bb="32" group="32" />
+                      </DistributedParameter>
+                      <MoleculeAmount id="g6P8dLyZWU-9-4Yz8ePugA" name="CYP344" icon="ENZYME" persistable="0" isFixedValue="0" dim="Amount" quantityType="Enzyme" negativeValuesAllowed="0" formula="rMXLZglcaUaofPZ0c6I6Yw" mode="Logical" scaleDivisor="1" displayUnit="µmol">
+                        <Children>
+                          <Parameter id="kr9ZVUkPr0uUFZgj_UKo7g" name="Degradation coefficient" description="First order turnover rate constant of the enzyme" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="c2fNMePAyki4XPdR-AEHaQ" isDefault="1" displayUnit="1/min">
+                            <ValueOrigin id="33" source="Other" description="OSP Suite Manual Chapter 16. PK-Sim®- Compounds: Defining inhibition/induction processes" />
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="P45bPOPMDEiowTOQ9rE6Fg" name="Relative expression" description="Relative expression" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0">
+                            <Info min="0" flag="60" seq="1" ref="0" bb="32" group="91" />
+                          </Parameter>
+                          <Parameter id="tGCGtFUEnEmOmw-_DOG0Jw" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0">
+                            <Info min="0" flag="58" seq="1" ref="0" bb="32" group="91" />
+                          </Parameter>
+                          <Parameter id="EjS6kCeCTk23Ks1GtjFEvQ" name="Relative expression out." description="Relative Expression that will be used in the simulation" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="fbRCNZOks0i0JlaOaYnbvg" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="oT5qRB0xfE2GbCXPEu8r4g" name="Start amount" description="Start amount of molecule" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" formula="EPX-QNxBZE2pcwiBNY6NfA" isDefault="1" displayUnit="µmol">
+                            <Info flag="54" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="9xR7Cx_0sUesbYM6K2f9Gw" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="_5AQF4X5mkuTWnIB24ghvw" isDefault="1" displayUnit="µmol/l">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Parameter id="3dZBaJ-PlECj8Q_1KR4xew" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="kE7RYVS5SEOwqbrykq3hkQ" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                          </Parameter>
+                          <Parameter id="IRgF8Is5pE-2IyrZ6b3Exw" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="omOzQblzLU-xTYjWMcbe5g" isDefault="1" displayUnit="min">
+                            <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                        </Children>
+                      </MoleculeAmount>
+                      <MoleculeAmount id="CSHZ6BJVOEyAMrV3APtuzA" name="Aciclovir" icon="DRUG" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" negativeValuesAllowed="0" mode="Logical" scaleDivisor="1" value="0" displayUnit="µmol">
+                        <Children>
+                          <Parameter id="tM7UqqdmIkyxOplwI4D8CQ" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="_5AQF4X5mkuTWnIB24ghvw" isDefault="1" displayUnit="µmol/l">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Parameter id="TaLJAKK_B0uEmg0XZnuzyA" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" rHSFormula="E3tOmVPRyUOHkLeJ9yW4Wg" value="0" displayUnit="µmol">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Parameter id="DPW6lvme4kqX2GgC_BAUZw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                          </Parameter>
+                          <Parameter id="CmZGSUjdsUOOu2oJcU30ow" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="MI9QZS9kSE2CQjAyhIkKpg" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="HdzWc4yGK02K6i32lf_mfw" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="um8Ck8fh2UmXNOHK-BY7Wg" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="hDcbSyxuIkSdm6IbhFAh3w" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="EvRoEadg00-brqORO6I8EQ" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="mPfKqF601kKXU-oKDdzXMA" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_Do65_222ESzhLxF552BzQ" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="Rr5LBONNrUakBF6WHz__Gg" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="75tZ0v-ISUmbYZKmVh27qw" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="RWRebtGYK02AB7htA2pXqQ" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="fXc6pfpUeEevuCPMmJnKfg" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="DiNnuwbLhUKPkNLtxQLBDQ" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ibLg73UlaEuWFW_YDtAhWQ" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="c6dVXZhfL0e71rtnf5XoFA" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="XE8mGz7zpEON8ssezgETxA" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="VRByKOMehkGV5B2jYXX5jw" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_o6qPDPfB0WU9jjsc0dioA" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="ZM7CsxPZGkSVdMc0gNu2Cw" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="hm0R1xRdjEKXtrUPDMgnCQ" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="xSTwTfwntUyCzG9xRR5WLA" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="AarhpUPWUkWqtwj7eigYbA" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="DoZk15t_S0yVmuZwhonAqA" name="Solubility" description="Solubility" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="82yttmHKKEu7jrYcLjDDVA" isDefault="1" displayUnit="mg/l">
+                            <Info min="0" flag="122" seq="1" ref="0" bb="2" group="42" />
+                          </Parameter>
+                          <Parameter id="Axkwpx9L6U-wuhdt6SkSVw" name="Solubility table" description="Solubility table" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="ojlXuIW-gEaDb2MBPclacw" isDefault="1" displayUnit="mg/l">
+                            <Info min="0" flag="50" seq="1" ref="0" bb="2" group="42" />
+                          </Parameter>
+                          <Parameter id="b93R27UeL0KFCPD6yB_etw" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_GBjn7UZQEC2lSyqCzPsyw" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="IbsHIBrwykCW0zABAE_l1w" name="Effective concentration in lumen" description="In case of supersaturation: molecule amount divided by liquid volume. Otherwise: Min(intestinal solubility; molecule amount divided by liquid volume)." icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="CIvG4C-tqEujXj5hfgY5zw" isDefault="1" displayUnit="µmol/l">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="42" />
+                          </Parameter>
+                          <Observer id="qCWxWVjVR0yKyEQYWqDBvQ" name="Concentration in lumen" description="Concentration of the molecule in lumen" icon="Observer" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" negativeValuesAllowed="1" formula="SEsNpt8BTUG8roHXWpFOQA" displayUnit="µmol/l" />
+                          <Observer id="Dc0ndGctskCGImWjaQU0gA" name="Fraction of oral drug mass absorbed into mucosa segment" description="Fraction of oral drug mass absorbed into mucosa segment" icon="Observer" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Drug, Observer" negativeValuesAllowed="1" formula="r43vCSc7BEe5-dGA5yh3BA" />
+                        </Children>
+                      </MoleculeAmount>
+                    </Children>
+                  </Container>
+                  <Container id="fitLwZdQGUqPqO1eHGEd4A" name="LowerJejunum" description="Lower Jejunum" icon="LowerJejunum" mode="Physical" containerType="Compartment">
+                    <Tags>
+                      <Tag value="Lumen" />
+                      <Tag value="LumenSegment" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="Jeem2NWxQkqRKwRd6-73SA" name="Absorption of liquid" description="rate of liquid outflow" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Ynnwj9PQKU-moKFAqxuzHA" isDefault="1" displayUnit="1/min">
+                        <Info flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="xoFrmuEdNUeFqCEtXoFI_w" name="Distal radius" description="Distal radius of intestinal segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="qN0sQEkpKUSNvqPOFISgPQ" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="LVsl51DdQ0y400UyMQ8HQg" name="Effective surface area" description="Effective surface area of GI segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="UDKQRMZb0kGECYiG1jVLSA" isDefault="1" displayUnit="cm²">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
+                        <Info min="0" flag="52" seq="1" ref="0" bb="32" group="33" />
+                      </Parameter>
+                      <Parameter id="TtoIluOtUUil0Dyp0PFAlQ" name="FillLevelFlag" description="Fill Level Flag" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="GLqHpG_OJkWM8l0SHiAa5g" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="X_9_xows6UGUXoE1j0qqdQ" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="aVy7eAeHjE6ETh8kdqeSuQ" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="VgTLVTOmYUybg3rk1P8b_A" name="Geometric surface area" description="Geometric surface area of GI segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="wsKEN3Lx60Ku0hovyuGDqw" isDefault="1" displayUnit="cm²">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="62" seq="1" ref="0" bb="32" group="33" />
+                      </Parameter>
+                      <Parameter id="MNaRllCgyEStAyUMuwb4tQ" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="S6ibVHLAdUKe1j4A6fJ17Q" isDefault="1" displayUnit="1/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="R_nhIj32xEmNpi_8qPFFqQ" name="Length" description="Length" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="sIXkaS02_UGII5sFXg9TKg" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="106" seq="1" ref="0" bb="32" group="34" />
+                      </Parameter>
+                      <Parameter id="Ep-KjbpM-EGig6lcmyZPkA" name="Liquid" description="Liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="DxFS8aU9SUGHF72wLzZs7A" isDefault="1" rHSFormula="B-UMKn6Wv0SA8NiHCW9k8A" displayUnit="l">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="fqc-6np16UugDRv4dQV0eA" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="a6eeTyh1CkuiJ_SkSs9-AA" isDefault="1" displayUnit="l/min">
+                        <Info flag="52" seq="1" ref="0" bb="2" group="39" />
+                      </Parameter>
+                      <Parameter id="R_0H5F58ZE23LYhFz4VOhQ" name="Proximal radius" description="Proximal radius of intestinal segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="FyJ0mmQ3tkGYaA3eL3fCSg" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="9dPUNOeUh06K2V0QLYtgwg" name="Secretion of liquid" description="Rate of liquid inflow" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="wDHvGgnYb0OIjWasfIkAVQ" isDefault="1" displayUnit="l/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="cShsNTSKGUOpYooDTavW9A" name="Thickness of gut wall" description="Thickness of Gut Wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="JHk9xtQ6YUWAs-vav0AWPg" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="38" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <Parameter id="3irKLTxs6U2N9C8nhqfmDA" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="v0bWMujBVUKTXasj7lfskg" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="62" seq="1" ref="0" bb="2" group="56" />
+                      </Parameter>
+                      <Parameter id="3mkAwEE5vE6GkpI_EaUXKA" name="Volume (gut wall)" description="Volume of the gut wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="4SyJGzZAXU6urc8pWDhBUw" isDefault="1" displayUnit="l">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="62" seq="1" ref="0" bb="32" group="44" />
+                      </Parameter>
+                      <Parameter id="qLVO2uxaiEmBR5e8ltd7bw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="WiDWMA7xi02WdVvl1Rjr0g" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="dhWFa1CeAkKjEVKBvB9frg" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.064841">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="58" seq="1" ref="0" bb="32" group="43" />
+                      </Parameter>
+                      <Parameter id="Hjrc2KjZ5kis_4ikPPgFyg" name="Intestinal transit rate" description="Transit rate along intestinal segments" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="5.0162" displayUnit="1/min">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="54" seq="1" ref="0" bb="32" group="46" />
+                      </Parameter>
+                      <Parameter id="7md4OgdZykG4nJhjZTo3nw" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0670329582" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="34" />
+                      </Parameter>
+                      <Parameter id="6Ce96KWBfEauCXZsy1fKPg" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.299751712">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="34" />
+                      </Parameter>
+                      <Parameter id="3xL-st_a30G5h8xsLnccaw" name="Microvilli factor" description="Microvilli factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="25">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="38" seq="1" ref="0" bb="32" group="33" />
+                      </Parameter>
+                      <Parameter id="RQs_xUt7gEuJxJBaF-X1rw" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0019411088" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="haFN0KjPCUKEWfxLOd4pVg" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.008680069">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="tsD9MW2y3UugrwnJfo1SwA" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0018117016" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="TiY0gLuT7UylTCoaaJclhQ" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.008101398">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="lNZoNaUav068jijWHpm8zg" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0196976609" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <Parameter id="51W2Y6QUwkatEyrYoLHczw" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0465856499" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <Parameter id="o1c_RqgAy0ehbH7R_IjrAA" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.30703115" displayUnit="1/cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <Parameter id="RuYGW9FigUS3t4hwMc324g" name="pH" description="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="6.9167">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
+                        <Info min="0" max="14" flag="122" seq="1" ref="0" bb="32" group="41" />
+                      </Parameter>
+                      <DistributedParameter id="kPIgKQIN70CypjaxxoWmhQ" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="yzB5-eXGaU24K-AupHOXKg" mode="Logical" isDefault="1">
+                        <Children>
+                          <Parameter id="N334y4jzs0-bS6NpqegwyA" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="32" group="32" />
+                          </Parameter>
+                          <Parameter id="NM-5ZTQezkW1V2H7BIPaGw" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="372.9358">
+                            <Info min="0" flag="50" seq="1" ref="0" bb="32" group="32" />
+                          </Parameter>
+                          <Container id="GuRCWPOnNUyG0cfkJBYlUw" name="Aciclovir" mode="Logical" containerType="Molecule" />
+                        </Children>
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="122" seq="1" ref="0" bb="32" group="32" />
+                      </DistributedParameter>
+                      <MoleculeAmount id="f_gi-7lF0Uyn9Af77ctXBw" name="CYP344" icon="ENZYME" persistable="0" isFixedValue="0" dim="Amount" quantityType="Enzyme" negativeValuesAllowed="0" formula="rMXLZglcaUaofPZ0c6I6Yw" mode="Logical" scaleDivisor="1" displayUnit="µmol">
+                        <Children>
+                          <Parameter id="yoFlCAGPnUqWfADiJYqtKw" name="Degradation coefficient" description="First order turnover rate constant of the enzyme" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="c2fNMePAyki4XPdR-AEHaQ" isDefault="1" displayUnit="1/min">
+                            <ValueOrigin id="33" source="Other" description="OSP Suite Manual Chapter 16. PK-Sim®- Compounds: Defining inhibition/induction processes" />
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="4zoJ6MkHz0Szm4MvsX37Cw" name="Relative expression" description="Relative expression" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0">
+                            <Info min="0" flag="60" seq="1" ref="0" bb="32" group="91" />
+                          </Parameter>
+                          <Parameter id="wLyEOLHBnkOhs_3IlteKFg" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0">
+                            <Info min="0" flag="58" seq="1" ref="0" bb="32" group="91" />
+                          </Parameter>
+                          <Parameter id="rhtHPhvpXEqvDfx5KucxeQ" name="Relative expression out." description="Relative Expression that will be used in the simulation" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="fbRCNZOks0i0JlaOaYnbvg" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="e5APjnQzBEiPbxeEnQR0Yw" name="Start amount" description="Start amount of molecule" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" formula="EPX-QNxBZE2pcwiBNY6NfA" isDefault="1" displayUnit="µmol">
+                            <Info flag="54" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="6yPY8Lt1Y0iptptHMgqxOw" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="_5AQF4X5mkuTWnIB24ghvw" isDefault="1" displayUnit="µmol/l">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Parameter id="w4mjGl-4GkOuvQikKYIDQw" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ju57FM-vlUubqKYJiIcCHA" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                          </Parameter>
+                          <Parameter id="08SMEkURX0K3I21iArAt_g" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="dy7JAp91X0O3T4T-LUxu4A" isDefault="1" displayUnit="min">
+                            <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                        </Children>
+                      </MoleculeAmount>
+                      <MoleculeAmount id="PAqF1HO7pkuY5X-5OikQTw" name="Aciclovir" icon="DRUG" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" negativeValuesAllowed="0" mode="Logical" scaleDivisor="1" value="0" displayUnit="µmol">
+                        <Children>
+                          <Parameter id="Lph7ghH3m0-esEFVnkW9cQ" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="_5AQF4X5mkuTWnIB24ghvw" isDefault="1" displayUnit="µmol/l">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Parameter id="4WxWGUT0e0aFJG83VX-rXg" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" rHSFormula="nEs9MSx3tEyr5-j_OYVqew" value="0" displayUnit="µmol">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Parameter id="H5CF5y8pI02uHU0-GB7RfQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                          </Parameter>
+                          <Parameter id="u1ntJs_17EO96zJQ70s0Yw" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="g1wzgEg0ekqhpJy5nk2Z-A" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="XZgbJEfnfECu0uF0jYNQEg" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="FkXsULsSr0ucMfNT9xLfyw" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="ouAVQ4Y4lkO6tXk5HAStgg" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="3wKQb_Bft0Oxh5bsKPpVmA" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="lqnN9y5JlkKFETF2cc7jqw" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ib5KIm2Z8Ua7iaUuW3_ctQ" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="SFxobJ9ZTUarjEepIgvNTg" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="c-3EsSzM0Eab0oiRQ2HdOw" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="zn63hd5QokW9C61Po_4JoA" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="1nHC2IjAyECAsCPnVd-k0Q" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="o9ROJlLwMkmEd94oJMioVQ" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="k85EbHl3fk-5BW2Xg3ii8w" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="b8RDVjyayUa5-yoSDNTLjQ" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="4FDTxuZ8z0eyegMWn6GViw" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="NtqPa-Q33UiN-ljwLFyQMg" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="jFwKfTbK4kaN4Y7_03ddxA" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="1vGmiaEzaUmtkzuvShu2-w" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="PocmRYzpw0uG5lKRvIi7-g" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="xBttUihlREW8dk-EsMiYlA" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="w1JAPPpT00qaIfYH0e3BeA" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="E3mPMVxAGUeUuK3K2YN64Q" name="Solubility" description="Solubility" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="PrMyHl2wu0-PVa3tZw-Tsg" isDefault="1" displayUnit="mg/l">
+                            <Info min="0" flag="122" seq="1" ref="0" bb="2" group="42" />
+                          </Parameter>
+                          <Parameter id="DXNI2VZOVECa2ZnUDdsTtg" name="Solubility table" description="Solubility table" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="69lhebuQbkWMBz5_zLV-AQ" isDefault="1" displayUnit="mg/l">
+                            <Info min="0" flag="50" seq="1" ref="0" bb="2" group="42" />
+                          </Parameter>
+                          <Parameter id="TMlbmv_aHECNINV3N8K9ag" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="AFFCoKYIR0aYbIN_4yl7ag" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="JUJYu-fwm0ycJ_qCrfjd0w" name="Effective concentration in lumen" description="In case of supersaturation: molecule amount divided by liquid volume. Otherwise: Min(intestinal solubility; molecule amount divided by liquid volume)." icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="SFeqOE2mMka93nQskNeB2w" isDefault="1" displayUnit="µmol/l">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="42" />
+                          </Parameter>
+                          <Observer id="R8Ze0KJtdUazaStMsTaLCw" name="Concentration in lumen" description="Concentration of the molecule in lumen" icon="Observer" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" negativeValuesAllowed="1" formula="SEsNpt8BTUG8roHXWpFOQA" displayUnit="µmol/l" />
+                          <Observer id="YwT93oNr5ECg1kTv3vZ8yA" name="Fraction of oral drug mass absorbed into mucosa segment" description="Fraction of oral drug mass absorbed into mucosa segment" icon="Observer" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Drug, Observer" negativeValuesAllowed="1" formula="r43vCSc7BEe5-dGA5yh3BA" />
+                        </Children>
+                      </MoleculeAmount>
+                    </Children>
+                  </Container>
+                  <Container id="KtAGIWDpxEqLmrfrjfTgOQ" name="UpperIleum" description="Upper Ileum" icon="UpperIleum" mode="Physical" containerType="Compartment">
+                    <Tags>
+                      <Tag value="Lumen" />
+                      <Tag value="LumenSegment" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="0AQVLr26_0m2dT_5jxaWJQ" name="Absorption of liquid" description="rate of liquid outflow" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="rfirLMWsSE6aVj0Oy80SUQ" isDefault="1" displayUnit="1/min">
+                        <Info flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="PiSAIIpakEefDOkvMi8pIg" name="Distal radius" description="Distal radius of intestinal segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="qN0sQEkpKUSNvqPOFISgPQ" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="c_K8YMlaCk--adZCkOuirQ" name="Effective surface area" description="Effective surface area of GI segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="UDKQRMZb0kGECYiG1jVLSA" isDefault="1" displayUnit="cm²">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
+                        <Info min="0" flag="52" seq="1" ref="0" bb="32" group="33" />
+                      </Parameter>
+                      <Parameter id="NZD7Xi2oSEu_ffLbOEw3Zw" name="FillLevelFlag" description="Fill Level Flag" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="GLqHpG_OJkWM8l0SHiAa5g" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="4U6l2Kiem0SqiLXCho6h9A" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="aVy7eAeHjE6ETh8kdqeSuQ" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="UWZ3ZQneGEG5_AV89bRwwg" name="Geometric surface area" description="Geometric surface area of GI segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="wsKEN3Lx60Ku0hovyuGDqw" isDefault="1" displayUnit="cm²">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="62" seq="1" ref="0" bb="32" group="33" />
+                      </Parameter>
+                      <Parameter id="wlFxT3rBrEmWYGgYS3l1Zw" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="5MlR6ew63U-C0D8z77vArw" isDefault="1" displayUnit="1/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="ADYORL3TfEaM-WscUeUcVA" name="Length" description="Length" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="sIXkaS02_UGII5sFXg9TKg" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="106" seq="1" ref="0" bb="32" group="34" />
+                      </Parameter>
+                      <Parameter id="ojUfzpRj1UGynqxY6Ulveg" name="Liquid" description="Liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="DxFS8aU9SUGHF72wLzZs7A" isDefault="1" rHSFormula="zdB7zwr5mku8T25Xc63gIg" displayUnit="l">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="j0g2ztiTrEyR-Oduk_-MOw" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="EZdO6dC3fUuAMZMR1IeL2w" isDefault="1" displayUnit="l/min">
+                        <Info flag="52" seq="1" ref="0" bb="2" group="39" />
+                      </Parameter>
+                      <Parameter id="UBs3LEyzZEqaaETbuQViKg" name="Proximal radius" description="Proximal radius of intestinal segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="FyJ0mmQ3tkGYaA3eL3fCSg" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="q5akPU28AE6tJp29uCEnhg" name="Secretion of liquid" description="Rate of liquid inflow" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="OYl9EQP4sEyhJ1WTzrCsng" isDefault="1" displayUnit="l/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="qZS4uiqxuECNgQ7q0UpGjA" name="Thickness of gut wall" description="Thickness of Gut Wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="JHk9xtQ6YUWAs-vav0AWPg" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="38" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <Parameter id="k-i44jsbk0SvlPGFE-e5Rw" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="v0bWMujBVUKTXasj7lfskg" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="62" seq="1" ref="0" bb="2" group="56" />
+                      </Parameter>
+                      <Parameter id="sWCIeWG65U6aWcgk9VZiCQ" name="Volume (gut wall)" description="Volume of the gut wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="YYj8An-up0WvwiqRQ9_p-A" isDefault="1" displayUnit="l">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="62" seq="1" ref="0" bb="32" group="44" />
+                      </Parameter>
+                      <Parameter id="lKdOFTVeR0im2JE5YL_d-w" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="WiDWMA7xi02WdVvl1Rjr0g" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="-Rwq-4oitUmskFuXKtvWgw" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.064841">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="58" seq="1" ref="0" bb="32" group="43" />
+                      </Parameter>
+                      <Parameter id="Uf1iBQ-t50-etCyq5lbZIw" name="Intestinal transit rate" description="Transit rate along intestinal segments" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="3.3745" displayUnit="1/min">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="54" seq="1" ref="0" bb="32" group="46" />
+                      </Parameter>
+                      <Parameter id="3Lus-HsHm0-WrYNybaQRmw" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0996435866" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="34" />
+                      </Parameter>
+                      <Parameter id="s-1qaNmhjEWzLEMykpcZDQ" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.445576869">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="34" />
+                      </Parameter>
+                      <Parameter id="m3p_q0t6nEix4t1c6fF5Vg" name="Microvilli factor" description="Microvilli factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="25">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="38" seq="1" ref="0" bb="32" group="33" />
+                      </Parameter>
+                      <Parameter id="rchnrNungUKf9vR3n9x4LQ" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0018117016" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="J-Vc9MvSvU-G_oHerScKjw" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.008101398">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="wypR6f_a_ES7yZ1KPy_RVA" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0015528871" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="P_UmHBZXR0-TwhjljP2OCA" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.006944055">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="bAsbuCdjcUyjJAL1TDJbww" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0260258863" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <Parameter id="H4nz7je1H0WFGQ9zowNVwA" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.061552122" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <Parameter id="LLiyxqEOo0O69S66Qs19_g" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.30703115" displayUnit="1/cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <Parameter id="-LJdGHGzYESUEvIk6PRMug" name="pH" description="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.2083">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
+                        <Info min="0" max="14" flag="122" seq="1" ref="0" bb="32" group="41" />
+                      </Parameter>
+                      <DistributedParameter id="mb3Qp64JAEOfnfVHM_UZCw" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="vuqpM13xwkS2VgM2p77Buw" mode="Logical" isDefault="1">
+                        <Children>
+                          <Parameter id="jK3oaOGgiEG_HstgT8mT0A" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="32" group="32" />
+                          </Parameter>
+                          <Parameter id="LDC0EGtCHEK_wtIhqAG1iA" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="260.7527">
+                            <Info min="0" flag="50" seq="1" ref="0" bb="32" group="32" />
+                          </Parameter>
+                          <Container id="-tOeJZNShkmJm33PPD-QFw" name="Aciclovir" mode="Logical" containerType="Molecule" />
+                        </Children>
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="122" seq="1" ref="0" bb="32" group="32" />
+                      </DistributedParameter>
+                      <MoleculeAmount id="VmUebBV4SkWT_Ldrb_dzNg" name="CYP344" icon="ENZYME" persistable="0" isFixedValue="0" dim="Amount" quantityType="Enzyme" negativeValuesAllowed="0" formula="rMXLZglcaUaofPZ0c6I6Yw" mode="Logical" scaleDivisor="1" displayUnit="µmol">
+                        <Children>
+                          <Parameter id="KhvvL0_uaUSk2I_ovOK5mQ" name="Degradation coefficient" description="First order turnover rate constant of the enzyme" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="c2fNMePAyki4XPdR-AEHaQ" isDefault="1" displayUnit="1/min">
+                            <ValueOrigin id="33" source="Other" description="OSP Suite Manual Chapter 16. PK-Sim®- Compounds: Defining inhibition/induction processes" />
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="-xup7QxQg0SzLmsWhCEHfA" name="Relative expression" description="Relative expression" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0">
+                            <Info min="0" flag="60" seq="1" ref="0" bb="32" group="91" />
+                          </Parameter>
+                          <Parameter id="9Bj1_xlDH0SaINB1t7iMiw" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0">
+                            <Info min="0" flag="58" seq="1" ref="0" bb="32" group="91" />
+                          </Parameter>
+                          <Parameter id="LNAA7OiNXkqTqg3hi7Xu1w" name="Relative expression out." description="Relative Expression that will be used in the simulation" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="fbRCNZOks0i0JlaOaYnbvg" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="L4yFpMZNwESTjARknabeDQ" name="Start amount" description="Start amount of molecule" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" formula="EPX-QNxBZE2pcwiBNY6NfA" isDefault="1" displayUnit="µmol">
+                            <Info flag="54" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="V3Tei0OjBkO1VA1M0yq9oA" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="_5AQF4X5mkuTWnIB24ghvw" isDefault="1" displayUnit="µmol/l">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Parameter id="dcrHOn-bHU6KxWps4uHIvw" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="6FgUtdrz-Uq8J9qoBHALmQ" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                          </Parameter>
+                          <Parameter id="_EZOZQoAkk2Qx2Zl2Q1SXQ" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="K1SDTbZ8YUCTXyeeAk7q3A" isDefault="1" displayUnit="min">
+                            <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                        </Children>
+                      </MoleculeAmount>
+                      <MoleculeAmount id="umlbmscJb0GFu_HR4Gat4w" name="Aciclovir" icon="DRUG" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" negativeValuesAllowed="0" mode="Logical" scaleDivisor="1" value="0" displayUnit="µmol">
+                        <Children>
+                          <Parameter id="VugwXRGgtEmBnASIaXqyZw" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="_5AQF4X5mkuTWnIB24ghvw" isDefault="1" displayUnit="µmol/l">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Parameter id="Z9GOzP5O7kCqt_EXBZtd8Q" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" rHSFormula="Yvf79BeUDU-oXL8iZnNAkA" value="0" displayUnit="µmol">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Parameter id="R3mii9iUpEORCl0Qr_yGaA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                          </Parameter>
+                          <Parameter id="33cboS2_D0KtBWWHh7YLFw" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="O3uxVDwrlEumwqL8IVVEEQ" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="-4nzpEWGhkWk4NNmOkOKSQ" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="9yB8dK88ski3X8cMxAjQrw" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="yxk9nUaJwUaJfrRahiZp0Q" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BE5HxPL8uEq_C9UBNM3AMQ" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="ArcveOwcA0KyxXCy7zbfdw" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="EzoirkNDwEWaWnKwmkU2lg" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="YVd0_up5Q02A0ieeP-MzEg" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_mYiqtX_ykSSz73N_CjL7Q" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="AMh6uBbugkyKP9DIabBHLA" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="C8A5qLMLg0aZv5taQMlRiw" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="NghRfuGaoUai56QTx_Vo-Q" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="AjnuMJ41uUiMVpoOjwheVw" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="SsiLfOho9EKfPL7Bt_pSIw" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="eVfeR7mXtE2-cr4_WaDsDA" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="L7eeGHyZ10CzyNFtiy5izA" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="H36nTdv6TkydadvpGTkosA" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="D6x3CVYm-Uq1nPixFgCj1g" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="9m1OSGYo_0WYremVutnGQA" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="Swnq_wMq4EuYYF9-Dh3iKg" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="9CEoVwA-QUGIqMnT-xbNkA" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="a8Nh7uXii0mOLfBdYVP6oQ" name="Solubility" description="Solubility" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="ladp0W7xuUeNIr-i8THx2Q" isDefault="1" displayUnit="mg/l">
+                            <Info min="0" flag="122" seq="1" ref="0" bb="2" group="42" />
+                          </Parameter>
+                          <Parameter id="iKjDXSMCLEyeDtnqSc5TDQ" name="Solubility table" description="Solubility table" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="YcpSnBpyNkCCG2Do_spEfg" isDefault="1" displayUnit="mg/l">
+                            <Info min="0" flag="50" seq="1" ref="0" bb="2" group="42" />
+                          </Parameter>
+                          <Parameter id="0wSKOvUzGUGfp3cFbYto8g" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="rl0cwU8ORUeGVyhC6NyUug" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="PLdDDT9pjkSrHKwBY_yU1Q" name="Effective concentration in lumen" description="In case of supersaturation: molecule amount divided by liquid volume. Otherwise: Min(intestinal solubility; molecule amount divided by liquid volume)." icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="i1uuxvgmqUy-t7-UD_O8yA" isDefault="1" displayUnit="µmol/l">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="42" />
+                          </Parameter>
+                          <Observer id="NNEf8btaoU2hW_UMuByd-g" name="Concentration in lumen" description="Concentration of the molecule in lumen" icon="Observer" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" negativeValuesAllowed="1" formula="SEsNpt8BTUG8roHXWpFOQA" displayUnit="µmol/l" />
+                          <Observer id="sz1dOyJAG0yHRSYrGCwYEg" name="Fraction of oral drug mass absorbed into mucosa segment" description="Fraction of oral drug mass absorbed into mucosa segment" icon="Observer" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Drug, Observer" negativeValuesAllowed="1" formula="r43vCSc7BEe5-dGA5yh3BA" />
+                        </Children>
+                      </MoleculeAmount>
+                    </Children>
+                  </Container>
+                  <Container id="gjNISeFIg0K-eV7qBurIeg" name="LowerIleum" description="Lower Ileum" icon="LowerIleum" mode="Physical" containerType="Compartment">
+                    <Tags>
+                      <Tag value="Lumen" />
+                      <Tag value="LumenSegment" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="kLAQtvY1mk-CKzgaaYQejQ" name="Absorption of liquid" description="rate of liquid outflow" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="xrkxSAAhckqc6UHfRF731Q" isDefault="1" displayUnit="1/min">
+                        <Info flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="R98pPIeA9kO4sgpMuBNqkg" name="Distal radius" description="Distal radius of intestinal segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="qN0sQEkpKUSNvqPOFISgPQ" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="y_k8OSnbhki-DYOnBu2m-w" name="Effective surface area" description="Effective surface area of GI segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="UDKQRMZb0kGECYiG1jVLSA" isDefault="1" displayUnit="cm²">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
+                        <Info min="0" flag="52" seq="1" ref="0" bb="32" group="33" />
+                      </Parameter>
+                      <Parameter id="UQTS6NT0i0CAPp4BXLjRRw" name="FillLevelFlag" description="Fill Level Flag" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="GLqHpG_OJkWM8l0SHiAa5g" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="9-p-9t6s-0SpcWAJ1KMtSg" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="aVy7eAeHjE6ETh8kdqeSuQ" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="uBG-afOLeUGMnLDjytlxvA" name="Geometric surface area" description="Geometric surface area of GI segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="wsKEN3Lx60Ku0hovyuGDqw" isDefault="1" displayUnit="cm²">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="62" seq="1" ref="0" bb="32" group="33" />
+                      </Parameter>
+                      <Parameter id="jj_wwLS7206a6hSxhD3vJQ" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="xTnllGAzkUuVSl5Jy7J9KQ" isDefault="1" displayUnit="1/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="mqJS-Ys4qUKuB-V-ZUBXEw" name="Length" description="Length" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="sIXkaS02_UGII5sFXg9TKg" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="106" seq="1" ref="0" bb="32" group="34" />
+                      </Parameter>
+                      <Parameter id="vuZN0zNzh0C0q7Tl2HjymQ" name="Liquid" description="Liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="DxFS8aU9SUGHF72wLzZs7A" isDefault="1" rHSFormula="jlazgzZxRUS_71E4xZJ0nw" displayUnit="l">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="Avaok3bZuk6cgR9hu79ybQ" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="2ugNnp2S5Ee7gVhdPwGYGw" isDefault="1" displayUnit="l/min">
+                        <Info flag="52" seq="1" ref="0" bb="2" group="39" />
+                      </Parameter>
+                      <Parameter id="dXa_xiQYnkm9hCZ74bGmtQ" name="Proximal radius" description="Proximal radius of intestinal segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="FyJ0mmQ3tkGYaA3eL3fCSg" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="mTUDjaLkiEmjPFcp78wlJg" name="Secretion of liquid" description="Rate of liquid inflow" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="6bPVB160Akuw9A8hOKf7fQ" isDefault="1" displayUnit="l/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="tzuIQAVMekCfKUwC4IaDXA" name="Thickness of gut wall" description="Thickness of Gut Wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="JHk9xtQ6YUWAs-vav0AWPg" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="38" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <Parameter id="AKFXmt3HaUCoHpFi1t8qNg" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="v0bWMujBVUKTXasj7lfskg" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="62" seq="1" ref="0" bb="2" group="56" />
+                      </Parameter>
+                      <Parameter id="4rCym1S3_EGLbYSVqHai0g" name="Volume (gut wall)" description="Volume of the gut wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="FAIAR75EsUmhwwN-DiAHrQ" isDefault="1" displayUnit="l">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="62" seq="1" ref="0" bb="32" group="44" />
+                      </Parameter>
+                      <Parameter id="ybQc6Bf7AECLzHjKLKy9Qg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="WiDWMA7xi02WdVvl1Rjr0g" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="9ZVXyDlWI022-gF81jAV8g" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.064841">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="58" seq="1" ref="0" bb="32" group="43" />
+                      </Parameter>
+                      <Parameter id="gxBsgP6A6Uq7lAD2ApanCg" name="Intestinal transit rate" description="Transit rate along intestinal segments" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="3.3745" displayUnit="1/min">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="54" seq="1" ref="0" bb="32" group="46" />
+                      </Parameter>
+                      <Parameter id="DHDX9_BRwE2GhrDJVGcMTw" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0996435866" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="34" />
+                      </Parameter>
+                      <Parameter id="tPN5FuytQkOZr8fFLqfKSA" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.445576869">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="34" />
+                      </Parameter>
+                      <Parameter id="AQ7t3BuuD0qT2qt4mBHy3A" name="Microvilli factor" description="Microvilli factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="25">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="38" seq="1" ref="0" bb="32" group="33" />
+                      </Parameter>
+                      <Parameter id="XQ2v9p7UnUWqEI8pzTNQ_Q" name="pH" description="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.4583">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
+                        <Info min="0" max="14" flag="122" seq="1" ref="0" bb="32" group="41" />
+                      </Parameter>
+                      <Parameter id="0TFWDqFfX0-6wgLmhjw3lQ" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0015528871" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="pCVq43JNFEucF62QwxXP-g" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.006944055">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="Lq40qiATLUG6_HuQ1n_59w" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0012940725" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="VD7zwrEP5E-LKw2O7vEIJg" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.005786713">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="xQm5nRxm8UinODXfNu_crQ" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0148137399" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <Parameter id="VQm9dLSSmE-VsJEt4KJj8Q" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0350288649" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <Parameter id="scGhzvsTn0a1NeDpBTvZPw" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.30705627" displayUnit="1/cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <DistributedParameter id="ltGtxdSK4E2ceOWN6FHDtA" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="7lVLFMkrEkydNN53RxgTjg" mode="Logical" isDefault="1">
+                        <Children>
+                          <Parameter id="cGKln-LK5USzy4kee1rrfA" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="32" group="32" />
+                          </Parameter>
+                          <Parameter id="ZfXKhMqZ1kicKyAhE0F9Lw" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="146.565">
+                            <Info min="0" flag="50" seq="1" ref="0" bb="32" group="32" />
+                          </Parameter>
+                          <Container id="rXRspO-e10Ku9SJKiRr9wA" name="Aciclovir" mode="Logical" containerType="Molecule" />
+                        </Children>
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="122" seq="1" ref="0" bb="32" group="32" />
+                      </DistributedParameter>
+                      <MoleculeAmount id="Z5mYOdhqJUy-jo-1t97lSg" name="CYP344" icon="ENZYME" persistable="0" isFixedValue="0" dim="Amount" quantityType="Enzyme" negativeValuesAllowed="0" formula="rMXLZglcaUaofPZ0c6I6Yw" mode="Logical" scaleDivisor="1" displayUnit="µmol">
+                        <Children>
+                          <Parameter id="u-1K3W-NHUu1T9D8L8YoKA" name="Degradation coefficient" description="First order turnover rate constant of the enzyme" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="c2fNMePAyki4XPdR-AEHaQ" isDefault="1" displayUnit="1/min">
+                            <ValueOrigin id="33" source="Other" description="OSP Suite Manual Chapter 16. PK-Sim®- Compounds: Defining inhibition/induction processes" />
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="RGvfv2-DUU6_VcNwd42dyQ" name="Relative expression" description="Relative expression" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0">
+                            <Info min="0" flag="60" seq="1" ref="0" bb="32" group="91" />
+                          </Parameter>
+                          <Parameter id="iZtV7CmpQkCMbVmvVnsYAg" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0">
+                            <Info min="0" flag="58" seq="1" ref="0" bb="32" group="91" />
+                          </Parameter>
+                          <Parameter id="HpY5jYuYn0GbYqfPSt7r0A" name="Relative expression out." description="Relative Expression that will be used in the simulation" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="fbRCNZOks0i0JlaOaYnbvg" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="Pzur9QEh4Eyfu5fK1toRKQ" name="Start amount" description="Start amount of molecule" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" formula="EPX-QNxBZE2pcwiBNY6NfA" isDefault="1" displayUnit="µmol">
+                            <Info flag="54" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="n9aDkK-3Dky8U8v6vZVQnQ" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="_5AQF4X5mkuTWnIB24ghvw" isDefault="1" displayUnit="µmol/l">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Parameter id="lIPCH2QXiUuTLGHzn6Dr7w" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="1JVdUYcG90WMujOMIgfRMA" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                          </Parameter>
+                          <Parameter id="Jh7oJXT350umCC_hHDHFyw" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="vYobVf1wzUmZcVSzucrRkQ" isDefault="1" displayUnit="min">
+                            <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                        </Children>
+                      </MoleculeAmount>
+                      <MoleculeAmount id="KB6CzQCDLEOmMSsCvtbbxA" name="Aciclovir" icon="DRUG" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" negativeValuesAllowed="0" mode="Logical" scaleDivisor="1" value="0" displayUnit="µmol">
+                        <Children>
+                          <Parameter id="cJX2Niu6TEi92B0dTOhAoQ" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="_5AQF4X5mkuTWnIB24ghvw" isDefault="1" displayUnit="µmol/l">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Parameter id="pSs-HAiSmUGbYHnx_H9fLA" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" rHSFormula="vopKaxwa2Uicv0muvAA5dw" value="0" displayUnit="µmol">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Parameter id="Jazy8NUxHkiHN5PBseLlOw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                          </Parameter>
+                          <Parameter id="zThHqWTBa064eQYvWkTVqQ" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="nNkfDvvQskasyyDDqPZV3w" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="F4PBqjtaBEOzsXurFaQlIw" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="gKQwfGu6XkC0-aIZeUsgVA" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="5vYRTqy5rkmwfN6eslhn-Q" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="zf65QVdJ5UG31qIxIFZUIg" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="U0dC1QnyFEyKmA5KyXwIYQ" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="vuqg-kT_aE-gyUrUtXSGbg" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="D3qD067CC0CvhLggEISLBw" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="go_qNZtbeki5LAgUlb86Ag" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="bfQC0mXWv0qwo6cm35H0mg" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="MPkaBo2cS0OGZBlPygcegw" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="Wiip9qYrZkmuEG4onsuIFw" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="bpgATPAIBEWZhhfOLHFNDg" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="uB5EUlWxJkmUUOQjQFMJgQ" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ImpAD75y0Eim0XcH_wfXvg" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="Es9BbrJIcUGGqCUEUcDj0A" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="z7xhdRgd1EOayp8pYgQUHA" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="2Dl0JBmGlEOeIkUkNlsbsA" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="GYIXgO4VBk2Gapo8hUkV4g" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="fZC1fbAYMkyYb-qOObPaWQ" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="-DvGsiDcXUuxPr4pngwh1A" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="XkYrXCgjxU6mJBYcpHlp0g" name="Solubility" description="Solubility" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="IIG1YDm9UUGYEn9i-DLYhQ" isDefault="1" displayUnit="mg/l">
+                            <Info min="0" flag="122" seq="1" ref="0" bb="2" group="42" />
+                          </Parameter>
+                          <Parameter id="OLb0sA1dgEKA4G665QvY8g" name="Solubility table" description="Solubility table" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="aBTYqvygwUG0hZuV_Cx9Rw" isDefault="1" displayUnit="mg/l">
+                            <Info min="0" flag="50" seq="1" ref="0" bb="2" group="42" />
+                          </Parameter>
+                          <Parameter id="K-t1kM5MzEqEhp-db_ZIpg" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="WD6lKS33P0m4ZGFKPld_lQ" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="bweRC1iIjkOWW0X4-5HAgQ" name="Effective concentration in lumen" description="In case of supersaturation: molecule amount divided by liquid volume. Otherwise: Min(intestinal solubility; molecule amount divided by liquid volume)." icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="bLwRTgHBEESgk3UjOjN8hA" isDefault="1" displayUnit="µmol/l">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="42" />
+                          </Parameter>
+                          <Observer id="3Mg43Kwkxkq69XIllTp09A" name="Concentration in lumen" description="Concentration of the molecule in lumen" icon="Observer" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" negativeValuesAllowed="1" formula="SEsNpt8BTUG8roHXWpFOQA" displayUnit="µmol/l" />
+                          <Observer id="fr070IotZECvEaN5QHPgJA" name="Fraction of oral drug mass absorbed into mucosa segment" description="Fraction of oral drug mass absorbed into mucosa segment" icon="Observer" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Drug, Observer" negativeValuesAllowed="1" formula="r43vCSc7BEe5-dGA5yh3BA" />
+                        </Children>
+                      </MoleculeAmount>
+                    </Children>
+                  </Container>
+                  <Container id="uYzhyHESRE2AJZ8aM48hjw" name="Caecum" description="Cecum" icon="Caecum" mode="Physical" containerType="Compartment">
+                    <Tags>
+                      <Tag value="Lumen" />
+                      <Tag value="LumenSegment" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="YDNVKAj-pkKa3jEhFgJLWg" name="Absorption of liquid" description="rate of liquid outflow" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="1AXHPK2EeECO08WuKnE6kg" isDefault="1" displayUnit="1/min">
+                        <Info flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="RA8zOZuevk2_HtgpZakCqw" name="Distal radius" description="Distal radius of intestinal segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="qN0sQEkpKUSNvqPOFISgPQ" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="VXgss4vNGUWIHLEtTmncCQ" name="Effective surface area" description="Effective surface area of GI segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="UDKQRMZb0kGECYiG1jVLSA" isDefault="1" displayUnit="cm²">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
+                        <Info min="0" flag="52" seq="1" ref="0" bb="32" group="33" />
+                      </Parameter>
+                      <Parameter id="EeEjpj5zJUacGvpS69xwxQ" name="FillLevelFlag" description="Fill Level Flag" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="GLqHpG_OJkWM8l0SHiAa5g" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="GgDgOmZ2-UuRX4PKJJBJ2g" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="aVy7eAeHjE6ETh8kdqeSuQ" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="lbCg7eQ9PEqoRyYmeRbE2g" name="Geometric surface area" description="Geometric surface area of GI segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="wsKEN3Lx60Ku0hovyuGDqw" isDefault="1" displayUnit="cm²">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="62" seq="1" ref="0" bb="32" group="33" />
+                      </Parameter>
+                      <Parameter id="-BUXvwLegkKm1NaNKJ-R-g" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="lX6QNUJR0E2lhr9MLqF8Qg" isDefault="1" displayUnit="1/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="0Qj8g75qeEG66ow9fYaLaQ" name="Length" description="Length" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="sIXkaS02_UGII5sFXg9TKg" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="106" seq="1" ref="0" bb="32" group="34" />
+                      </Parameter>
+                      <Parameter id="NHyzb3nIrkSMPnh6LsDqSQ" name="Liquid" description="Liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="DxFS8aU9SUGHF72wLzZs7A" isDefault="1" rHSFormula="3nGwb1yz0UeZiUeZkBRz0Q" displayUnit="l">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="jPJAW1gJc0KKgR6yPP1QtA" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="FkSEjncor0CL-CIp9oGcRg" isDefault="1" displayUnit="l/min">
+                        <Info flag="52" seq="1" ref="0" bb="2" group="39" />
+                      </Parameter>
+                      <Parameter id="hW4rFob8kkCFdiVA-FsqsA" name="Proximal radius" description="Proximal radius of intestinal segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="FyJ0mmQ3tkGYaA3eL3fCSg" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="tHDsRSEaI0ahADZkj6m6Nw" name="Secretion of liquid" description="Rate of liquid inflow" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Oj9WovUr7kC656zMXcS0qw" isDefault="1" displayUnit="l/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="FnB8NYvbvUq4n6IDy4wvug" name="Thickness of gut wall" description="Thickness of Gut Wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="JHk9xtQ6YUWAs-vav0AWPg" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="38" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <Parameter id="5mmCAIKzlki15icxXamEoQ" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="v0bWMujBVUKTXasj7lfskg" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="62" seq="1" ref="0" bb="2" group="56" />
+                      </Parameter>
+                      <Parameter id="JxKSYhPMj0OEn8nw1HuOzg" name="Volume (gut wall)" description="Volume of the gut wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="WxIxdaZ4NUenCPPxXWYEUQ" isDefault="1" displayUnit="l">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="62" seq="1" ref="0" bb="32" group="44" />
+                      </Parameter>
+                      <Parameter id="-y2f_jUo1ES1e_d25nsKVQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="WiDWMA7xi02WdVvl1Rjr0g" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="jsHG9joCrkCjTSrMVJXAcw" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0060009">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="58" seq="1" ref="0" bb="32" group="43" />
+                      </Parameter>
+                      <Parameter id="AFy18jlbX0uqsdkHw3MVTg" name="Intestinal transit rate" description="Transit rate along intestinal segments" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="18.3333" displayUnit="1/min">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="54" seq="1" ref="0" bb="32" group="46" />
+                      </Parameter>
+                      <Parameter id="GmlT-HsR-EiuuZG9WxD_yA" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.1152851235" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="34" />
+                      </Parameter>
+                      <Parameter id="HG231KF-gUi8RJgPA3b0Cw" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.026864843">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="34" />
+                      </Parameter>
+                      <Parameter id="_tK-_-UI2Ey77oZ2rSQKTQ" name="Microvilli factor" description="Microvilli factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="38" seq="1" ref="0" bb="32" group="33" />
+                      </Parameter>
+                      <Parameter id="Tc7YerNr5UiRaaVUHCyQzw" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.067256381" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="WMatSrGKmkuWEoJQEq78ag" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.015672726">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="N9CAr8IlEECPGRmJzBrfiA" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.067256381" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="Vt1QVpij40Og9uL5w_eE4g" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.015672726">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="xAKCE3vyF026436up0r-Aw" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.00877" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <Parameter id="Abs7pBiKPEygNXA2hi2DSw" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0446435379" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <Parameter id="ylQngfhP106n6SOYBw0Jpg" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0897885" displayUnit="1/cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <Parameter id="2blNUfAtkkarPxJYPZGC2Q" name="pH" description="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="5.7">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
+                        <Info min="0" max="14" flag="122" seq="1" ref="0" bb="32" group="41" />
+                      </Parameter>
+                      <DistributedParameter id="rVybiltVOEWHMGoaLCLrNQ" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="wVkXgnEWt0GdhrAkliObyA" mode="Logical" isDefault="1">
+                        <Children>
+                          <Parameter id="XrOg_1AJwESktJzXbh7Oxg" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="32" group="32" />
+                          </Parameter>
+                          <Parameter id="IbZxwSNFx0ylo-rsAJgFMw" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.8">
+                            <Info min="0" flag="50" seq="1" ref="0" bb="32" group="32" />
+                          </Parameter>
+                          <Container id="Ow99Q-ELv0-PnP_TY8fm_g" name="Aciclovir" mode="Logical" containerType="Molecule" />
+                        </Children>
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="122" seq="1" ref="0" bb="32" group="32" />
+                      </DistributedParameter>
+                      <MoleculeAmount id="FlNjsjafA0W-HpBPKrVaLA" name="CYP344" icon="ENZYME" persistable="0" isFixedValue="0" dim="Amount" quantityType="Enzyme" negativeValuesAllowed="0" formula="rMXLZglcaUaofPZ0c6I6Yw" mode="Logical" scaleDivisor="1" displayUnit="µmol">
+                        <Children>
+                          <Parameter id="h5Vmi9gNgU2nVP1HXlbmpg" name="Degradation coefficient" description="First order turnover rate constant of the enzyme" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="c2fNMePAyki4XPdR-AEHaQ" isDefault="1" displayUnit="1/min">
+                            <ValueOrigin id="33" source="Other" description="OSP Suite Manual Chapter 16. PK-Sim®- Compounds: Defining inhibition/induction processes" />
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="S-GnewF3NUemB2Yicl6NKg" name="Relative expression" description="Relative expression" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0">
+                            <Info min="0" flag="60" seq="1" ref="0" bb="32" group="91" />
+                          </Parameter>
+                          <Parameter id="5lF6ggk5EUqSsYODqubBPg" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0">
+                            <Info min="0" flag="58" seq="1" ref="0" bb="32" group="91" />
+                          </Parameter>
+                          <Parameter id="vhp7O4-7h0GsCcAQnFtZ7Q" name="Relative expression out." description="Relative Expression that will be used in the simulation" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="fbRCNZOks0i0JlaOaYnbvg" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="BrXtl7nsH02slGSqZS4kGw" name="Start amount" description="Start amount of molecule" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" formula="EPX-QNxBZE2pcwiBNY6NfA" isDefault="1" displayUnit="µmol">
+                            <Info flag="54" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="FAj83a57_UeORUntmqaTJg" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="_5AQF4X5mkuTWnIB24ghvw" isDefault="1" displayUnit="µmol/l">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Parameter id="WWkiUmLzBkmyfFIB2xrBUQ" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="cEWnTnCIAU2nqkGiTBSAEA" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                          </Parameter>
+                          <Parameter id="ikka0KFNY06WY7N5r5BwrA" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="5ifuXV1KYkiAY6g0LEVdfA" isDefault="1" displayUnit="min">
+                            <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                        </Children>
+                      </MoleculeAmount>
+                      <MoleculeAmount id="bl-WKAeEGkqp-gMj0y8wBQ" name="Aciclovir" icon="DRUG" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" negativeValuesAllowed="0" mode="Logical" scaleDivisor="1" value="0" displayUnit="µmol">
+                        <Children>
+                          <Parameter id="a4g5poTodk2l48XsulfgXQ" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="_5AQF4X5mkuTWnIB24ghvw" isDefault="1" displayUnit="µmol/l">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Parameter id="UG-xwoa5nkKC3RA10pd8Tg" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" rHSFormula="bvscd6KUXUiuxbn69Q3oeQ" value="0" displayUnit="µmol">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Parameter id="eqB3O805HkOJQTdykVHAhA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                          </Parameter>
+                          <Parameter id="luVfAnAsZUKdRwqnF9nYeA" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ephYTmUcU06FngdbztmnUw" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="HhVkTK_p2Eupp53Wb_Tb6A" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="swIoEG0vpEaKez_n3uCZdA" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="-B-iyE2qN0y5v9uiCy7Skg" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="-IBM-Yl3WkeLuqHArezABg" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="3tAet20Yckydxmi0lwWJ7A" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="wARGvy9GuUaspKUJG57Yug" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="W30zMiFKc0uifwDu4SWa9Q" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Nqkt2MJ1k0CFtSGp1ny61w" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="urLdDnu9_k6PAYNbMAKeSg" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TU6ZmtwqBkeQobd9Kbdkew" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="cIl1wEXVgUGHEaQThkLNkg" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="cCVMMsrhyUiZFUhq5JEbmg" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="P_CqRtcmqUmNVwit0WV_Ww" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="HwbDAFwLTEOOfKoEVUizBg" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="JnspP88PGkGfEHuE6jKN0w" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="XXNiTtYwEkaellAOzaSmeQ" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="WLx6jgoCNUis8DgaorXHaw" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="b5AjOW_M_EyB_PL8pYl0yg" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="BnhTS4Nc_k2SgV7g_wvDmQ" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="qMEGAMIYiUGULmImVhGZ6Q" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="jIFWzqd5KUGVQ0I_14oZcg" name="Solubility" description="Solubility" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="XIoSHXlTOkyQcAt17yvJAw" isDefault="1" displayUnit="mg/l">
+                            <Info min="0" flag="122" seq="1" ref="0" bb="2" group="42" />
+                          </Parameter>
+                          <Parameter id="ou3X4vSCPk6tqELlM1Y3mg" name="Solubility table" description="Solubility table" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="XPajWJITrEqA-2rCzydOEQ" isDefault="1" displayUnit="mg/l">
+                            <Info min="0" flag="50" seq="1" ref="0" bb="2" group="42" />
+                          </Parameter>
+                          <Parameter id="SENBfDVUxky3hzi20LJlnw" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ftmsQVL2oEC4Y40enTSALQ" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="5_UrMLP2mE6VnJaOK7QRsw" name="Effective concentration in lumen" description="In case of supersaturation: molecule amount divided by liquid volume. Otherwise: Min(intestinal solubility; molecule amount divided by liquid volume)." icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="bizPAOQh9UOBfuC9axr2Gg" isDefault="1" displayUnit="µmol/l">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="42" />
+                          </Parameter>
+                          <Observer id="6SVeUJaXyUG8s7HELG2QjA" name="Concentration in lumen" description="Concentration of the molecule in lumen" icon="Observer" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" negativeValuesAllowed="1" formula="SEsNpt8BTUG8roHXWpFOQA" displayUnit="µmol/l" />
+                          <Observer id="6a-EJXMEnEioowo-1_t3Yw" name="Fraction of oral drug mass absorbed into mucosa segment" description="Fraction of oral drug mass absorbed into mucosa segment" icon="Observer" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Drug, Observer" negativeValuesAllowed="1" formula="r43vCSc7BEe5-dGA5yh3BA" />
+                        </Children>
+                      </MoleculeAmount>
+                    </Children>
+                  </Container>
+                  <Container id="tkfxCJO3sk6qgcu2TdYoFQ" name="ColonAscendens" description="Colon Ascendens" icon="ColonAscendens" mode="Physical" containerType="Compartment">
+                    <Tags>
+                      <Tag value="Lumen" />
+                      <Tag value="LumenSegment" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="d2O3gF_IvUSbNZvSeheUxQ" name="Absorption of liquid" description="rate of liquid outflow" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="UL_C4rGicEGLrXVSD2tBjw" isDefault="1" displayUnit="1/min">
+                        <Info flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="5VYpWe2WXE6P3DcdLGleiQ" name="Distal radius" description="Distal radius of intestinal segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="qN0sQEkpKUSNvqPOFISgPQ" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="N_nkBLICnU2K8fcYdRdgxQ" name="Effective surface area" description="Effective surface area of GI segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="UDKQRMZb0kGECYiG1jVLSA" isDefault="1" displayUnit="cm²">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
+                        <Info min="0" flag="52" seq="1" ref="0" bb="32" group="33" />
+                      </Parameter>
+                      <Parameter id="pDxpClw4aU2B45psSRhmUw" name="FillLevelFlag" description="Fill Level Flag" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="GLqHpG_OJkWM8l0SHiAa5g" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="iNDFZPt5PkGmLF2P9xJ5rw" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="aVy7eAeHjE6ETh8kdqeSuQ" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="CKpsq8IlFUWK5aV6YKW68Q" name="Geometric surface area" description="Geometric surface area of GI segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="wsKEN3Lx60Ku0hovyuGDqw" isDefault="1" displayUnit="cm²">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="62" seq="1" ref="0" bb="32" group="33" />
+                      </Parameter>
+                      <Parameter id="ZyvYHktstE2BnlSkZpX0fg" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="lOPxvg6SLEu3jaGD6XrsHQ" isDefault="1" displayUnit="1/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="viaFZD0QrkSF7Mxwh_ALkg" name="Length" description="Length" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="sIXkaS02_UGII5sFXg9TKg" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="106" seq="1" ref="0" bb="32" group="34" />
+                      </Parameter>
+                      <Parameter id="V5uOps1yCUekT9KDXwUH2w" name="Liquid" description="Liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="DxFS8aU9SUGHF72wLzZs7A" isDefault="1" rHSFormula="5Qtn_nhf5Ui_EWb8xiU1OA" displayUnit="l">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="lglZ138D6UuwXRtY3nLW4Q" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="nPbKQ5qhvE6vO3i_r381cQ" isDefault="1" displayUnit="l/min">
+                        <Info flag="52" seq="1" ref="0" bb="2" group="39" />
+                      </Parameter>
+                      <Parameter id="xk_MVnwta0OyzPTMDwEl_w" name="Proximal radius" description="Proximal radius of intestinal segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="FyJ0mmQ3tkGYaA3eL3fCSg" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="iFK6Lwo2mEug6hYhiH73aA" name="Secretion of liquid" description="Rate of liquid inflow" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="iqDlDClRzk2uZGdUtLnmZg" isDefault="1" displayUnit="l/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="U9paeuEYvUGqthIDMSCh3g" name="Thickness of gut wall" description="Thickness of Gut Wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="JHk9xtQ6YUWAs-vav0AWPg" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="38" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <Parameter id="IZlrEGYsdEi1HDwCzhBhqw" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="v0bWMujBVUKTXasj7lfskg" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="62" seq="1" ref="0" bb="2" group="56" />
+                      </Parameter>
+                      <Parameter id="LBryv2V120WgPc-5AYMk1w" name="Volume (gut wall)" description="Volume of the gut wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="8Y6GCrG85EKw0YS6OF0Yvg" isDefault="1" displayUnit="l">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="62" seq="1" ref="0" bb="32" group="44" />
+                      </Parameter>
+                      <Parameter id="O-r-oby6xUG_Hz2xlwc6BQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="WiDWMA7xi02WdVvl1Rjr0g" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="G2IJLpUhHUKYeusUsjtMCA" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0060009">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="58" seq="1" ref="0" bb="32" group="43" />
+                      </Parameter>
+                      <Parameter id="KeO1HfpA-0y5MZqKjMUyLA" name="Intestinal transit rate" description="Transit rate along intestinal segments" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="1/min">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="54" seq="1" ref="0" bb="32" group="46" />
+                      </Parameter>
+                      <Parameter id="vI-gU1e70UOBM0jb9qHF0g" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.3117189273" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="34" />
+                      </Parameter>
+                      <Parameter id="LVtCBj2Y1U-07dlBlvPwhg" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.075727844">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="34" />
+                      </Parameter>
+                      <Parameter id="UUhgRYRqq069oMSMBvsQRw" name="Microvilli factor" description="Microvilli factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="38" seq="1" ref="0" bb="32" group="33" />
+                      </Parameter>
+                      <Parameter id="JrYVZYajTkyYGrdoDy8pIQ" name="pH" description="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="5.6">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
+                        <Info min="0" max="14" flag="122" seq="1" ref="0" bb="32" group="41" />
+                      </Parameter>
+                      <Parameter id="WnNiaz1cb0y74hvplgyY5w" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.067256381" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="jR2Z-hRQEEyOcMvQnXCxmQ" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.015672726">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="EdnooGBCPkWLGdlM10sghQ" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.067256381" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="-QbZzoBQ2k2xvV70n2M9Rw" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.015672726">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="O1-RoTKU8UKFJP-x60gIQQ" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.00554" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <Parameter id="ecFpCjEfKUahkuxXo6WaQg" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0280138174" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <Parameter id="sGmlbXGDBkSW7NuFeHxf-w" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.09106073" displayUnit="1/cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <DistributedParameter id="DWt2hN2KYUu6i4fdlWb6gQ" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DWVS57qFbkmpq-HF1wH5fQ" mode="Logical" isDefault="1">
+                        <Children>
+                          <Parameter id="QoC7lcbfQk6wf243HGjXBw" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="32" group="32" />
+                          </Parameter>
+                          <Parameter id="Wn_QeAeK_0S6NbmX96LEpw" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.5">
+                            <Info min="0" flag="50" seq="1" ref="0" bb="32" group="32" />
+                          </Parameter>
+                          <Container id="onagSqiMp0OT_OG2u0MQiw" name="Aciclovir" mode="Logical" containerType="Molecule" />
+                        </Children>
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="122" seq="1" ref="0" bb="32" group="32" />
+                      </DistributedParameter>
+                      <MoleculeAmount id="_GG4xVY-r0eHpBFvfMLTWg" name="CYP344" icon="ENZYME" persistable="0" isFixedValue="0" dim="Amount" quantityType="Enzyme" negativeValuesAllowed="0" formula="rMXLZglcaUaofPZ0c6I6Yw" mode="Logical" scaleDivisor="1" displayUnit="µmol">
+                        <Children>
+                          <Parameter id="hEJkDDtx_UStvNpvxyM-pA" name="Degradation coefficient" description="First order turnover rate constant of the enzyme" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="c2fNMePAyki4XPdR-AEHaQ" isDefault="1" displayUnit="1/min">
+                            <ValueOrigin id="33" source="Other" description="OSP Suite Manual Chapter 16. PK-Sim®- Compounds: Defining inhibition/induction processes" />
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="hhw2Yz5zykalm23KtHdzdg" name="Relative expression" description="Relative expression" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0">
+                            <Info min="0" flag="60" seq="1" ref="0" bb="32" group="91" />
+                          </Parameter>
+                          <Parameter id="VWZzpLpfEEyIJfvLiEG77g" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0">
+                            <Info min="0" flag="58" seq="1" ref="0" bb="32" group="91" />
+                          </Parameter>
+                          <Parameter id="FZd_GGamo0KROBw-uys_VA" name="Relative expression out." description="Relative Expression that will be used in the simulation" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="fbRCNZOks0i0JlaOaYnbvg" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="n57KoGD_-k2_gwhMJB89Ew" name="Start amount" description="Start amount of molecule" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" formula="EPX-QNxBZE2pcwiBNY6NfA" isDefault="1" displayUnit="µmol">
+                            <Info flag="54" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="NlNHUPBMZkyPmHallEhgIw" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="_5AQF4X5mkuTWnIB24ghvw" isDefault="1" displayUnit="µmol/l">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Parameter id="NgpKKXzTS0KrLUmEL8IecA" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ggvbAygjgU2cVnQHeqLSGw" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                          </Parameter>
+                          <Parameter id="BjTjNoG9e0G4j4hk00Z5Yg" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="I-2ep6EdIUe-MfvRNufTOg" isDefault="1" displayUnit="min">
+                            <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                        </Children>
+                      </MoleculeAmount>
+                      <MoleculeAmount id="JpU_43QuWEeLn_RwxMDZeA" name="Aciclovir" icon="DRUG" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" negativeValuesAllowed="0" mode="Logical" scaleDivisor="1" value="0" displayUnit="µmol">
+                        <Children>
+                          <Parameter id="zjFiNQ8Dk0mBgbbLBi8xkA" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="_5AQF4X5mkuTWnIB24ghvw" isDefault="1" displayUnit="µmol/l">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Parameter id="i_ojfons8kScRAdbButEgw" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" rHSFormula="q6saDs9NWkK3YPB7e-AfOQ" value="0" displayUnit="µmol">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Parameter id="Dq9fWRbWTUuSBteWuE9YdA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                          </Parameter>
+                          <Parameter id="HKp83A5ITUKWZP-KaCEHJQ" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="UMV-l0r1vUKooQr7Y2YQ7g" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="06MSby2NwUmyHGG7cb_h-Q" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="YUYbD2wDq0C_5QS1r3acDw" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="CdYdbmb4G0iFszEo0soCHA" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_G1nf0G2YUyjekEtCSe_CA" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="tp_PPA1bikWy3lfnSzDWcQ" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="T0XfCaLvckuESiW152Nh_w" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="abdfASoRoEml5hDPJlHfJg" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Q4GqmxpVx0qHfnG1sb21Yw" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="ngBtBtIQu0iSd_Sj_n4CdQ" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="efYBg6QsckqLRr9qwQZERQ" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="TVwMVQGi8EeDhUEU40i_Zw" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="D9wnl7tm6UiRiQ635N4mgw" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="wuI9NAomPESIOUviSBUQzg" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="EMgZKyo-f0eyqnEaTzfsaA" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="HM6AMVbgqk-1rSDtmKjzGg" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="8TjNAUw-8UyaCzJFphvYPA" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="Ardp7lHZV06qMlpGnhqwXQ" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ExWK20f8fE2Z4t-B2e3-Bw" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="OxrmpsLrHkeXdQCyTY8vQQ" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="NZVBxGn59U-ZD1w6S_Sh5g" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="W9eyDXtV2UqHKbucp6i_tQ" name="Solubility" description="Solubility" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="amEnaUX5ekOq8fd-5YBL9w" isDefault="1" displayUnit="mg/l">
+                            <Info min="0" flag="122" seq="1" ref="0" bb="2" group="42" />
+                          </Parameter>
+                          <Parameter id="ag2coTJwOEyPy6yoGLGuVg" name="Solubility table" description="Solubility table" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="npquNiSu5EO8AgwE2vnVSA" isDefault="1" displayUnit="mg/l">
+                            <Info min="0" flag="50" seq="1" ref="0" bb="2" group="42" />
+                          </Parameter>
+                          <Parameter id="XoxV-gV_hU2AUZom9Juckg" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="3WdVdm8Rt0SQ3M8HeQ6q6Q" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="ANh-3Njc7E6NNJzbCnnuwg" name="Effective concentration in lumen" description="In case of supersaturation: molecule amount divided by liquid volume. Otherwise: Min(intestinal solubility; molecule amount divided by liquid volume)." icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="rlzxxgqe3Eikfrqkl3M2iQ" isDefault="1" displayUnit="µmol/l">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="42" />
+                          </Parameter>
+                          <Observer id="sbNzR5hYJECdJxqr0FgK8w" name="Concentration in lumen" description="Concentration of the molecule in lumen" icon="Observer" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" negativeValuesAllowed="1" formula="SEsNpt8BTUG8roHXWpFOQA" displayUnit="µmol/l" />
+                          <Observer id="d3gBaB8MlUmuNvCDR3TcgQ" name="Fraction of oral drug mass absorbed into mucosa segment" description="Fraction of oral drug mass absorbed into mucosa segment" icon="Observer" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Drug, Observer" negativeValuesAllowed="1" formula="r43vCSc7BEe5-dGA5yh3BA" />
+                        </Children>
+                      </MoleculeAmount>
+                    </Children>
+                  </Container>
+                  <Container id="lYdNatoo8k6R4a61MnSWxw" name="ColonTransversum" description="Colon Transversum" icon="ColonTransversum" mode="Physical" containerType="Compartment">
+                    <Tags>
+                      <Tag value="Lumen" />
+                      <Tag value="LumenSegment" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="DTdV6Hm3L0u3VzbRhkafXg" name="Absorption of liquid" description="rate of liquid outflow" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="uIi1vJX3xEOQU0LQNdaqaA" isDefault="1" displayUnit="1/min">
+                        <Info flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="002qm_D300e21xgiWc5X3g" name="Distal radius" description="Distal radius of intestinal segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="qN0sQEkpKUSNvqPOFISgPQ" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="sBQJuyENdEe3JFW4qx5ilA" name="Effective surface area" description="Effective surface area of GI segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="UDKQRMZb0kGECYiG1jVLSA" isDefault="1" displayUnit="cm²">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
+                        <Info min="0" flag="52" seq="1" ref="0" bb="32" group="33" />
+                      </Parameter>
+                      <Parameter id="j_ILG5dYjUupGGt5jiEwcA" name="FillLevelFlag" description="Fill Level Flag" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="GLqHpG_OJkWM8l0SHiAa5g" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="mRCkjo_AqU2DIF2vBOZONw" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="aVy7eAeHjE6ETh8kdqeSuQ" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="QztReCeUzkWLJVpWW6jCHw" name="Geometric surface area" description="Geometric surface area of GI segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="wsKEN3Lx60Ku0hovyuGDqw" isDefault="1" displayUnit="cm²">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="62" seq="1" ref="0" bb="32" group="33" />
+                      </Parameter>
+                      <Parameter id="QXSoijaKvECpFWYA4tom2w" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="Tr5VoWR_c0ePtAg8OjsjNQ" isDefault="1" displayUnit="1/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="PO-2XT2GwUqECESA9FNxiQ" name="Length" description="Length" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="sIXkaS02_UGII5sFXg9TKg" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="106" seq="1" ref="0" bb="32" group="34" />
+                      </Parameter>
+                      <Parameter id="YiL7MZFITUWHM0ar4BTUXQ" name="Liquid" description="Liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="DxFS8aU9SUGHF72wLzZs7A" isDefault="1" rHSFormula="LuPYPK1v7ki9IYpoWMMyuw" displayUnit="l">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="AT5mqXPmwkqBpnqAJ-jsVg" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="hGimrzeyMkuimUQpRzWF8A" isDefault="1" displayUnit="l/min">
+                        <Info flag="52" seq="1" ref="0" bb="2" group="39" />
+                      </Parameter>
+                      <Parameter id="knWbwLMRK0y1JSYGm8OsgQ" name="Proximal radius" description="Proximal radius of intestinal segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="FyJ0mmQ3tkGYaA3eL3fCSg" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="mSej_cd-oEewxem3yVwH4Q" name="Secretion of liquid" description="Rate of liquid inflow" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="MToZdlq17UyJuSsyqgFmFg" isDefault="1" displayUnit="l/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="--NkdozF8k-kkOTVzrnbrw" name="Thickness of gut wall" description="Thickness of Gut Wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="JHk9xtQ6YUWAs-vav0AWPg" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="38" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <Parameter id="F5akfLjB-EqolQF49iQc6Q" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="v0bWMujBVUKTXasj7lfskg" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="62" seq="1" ref="0" bb="2" group="56" />
+                      </Parameter>
+                      <Parameter id="s9DGp4XBlUizrBrRe9LQhw" name="Volume (gut wall)" description="Volume of the gut wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="Vfiu4agurke6Bh14nW7Opw" isDefault="1" displayUnit="l">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="62" seq="1" ref="0" bb="32" group="44" />
+                      </Parameter>
+                      <Parameter id="iSR-7lOrAUSP48O28kRQJA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="WiDWMA7xi02WdVvl1Rjr0g" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="7Z7HyyQ0w0iHPvhGB0nA4w" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0060009">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="58" seq="1" ref="0" bb="32" group="43" />
+                      </Parameter>
+                      <Parameter id="uej7qpyD9ECV_DBMXO-W3g" name="Intestinal transit rate" description="Transit rate along intestinal segments" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="3.3333" displayUnit="1/min">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="54" seq="1" ref="0" bb="32" group="46" />
+                      </Parameter>
+                      <Parameter id="jdkS9sGs00-xXe7HfkiQdg" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.6886041141" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="34" />
+                      </Parameter>
+                      <Parameter id="s59faNRxj0WDg1WZlW1fHQ" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.144607745">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="34" />
+                      </Parameter>
+                      <Parameter id="Q9xeoZY9d02KHj47EMscGA" name="Microvilli factor" description="Microvilli factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="38" seq="1" ref="0" bb="32" group="33" />
+                      </Parameter>
+                      <Parameter id="7tMyVFW4bkqbZtyA82VfFg" name="pH" description="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="5.7">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
+                        <Info min="0" max="14" flag="122" seq="1" ref="0" bb="32" group="41" />
+                      </Parameter>
+                      <Parameter id="YHXndsKH9UWDXvNMOz51lQ" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.067256381" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="CWh7x-Dzek6THrgZXRbICQ" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.015672726">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="mXqdrIAQgUeywUQNlo-g7g" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0384322177" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="KNxUK419OUKXhK3hUjQmlg" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.008955843">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="nvziEz5W6Um3GhgNyS4cNw" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0076" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <Parameter id="FK15ZAqdHkWIjv3heVnI8w" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0394956146" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <Parameter id="JWXRC4Ew_0Wl4A5LbXHapg" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.08637087" displayUnit="1/cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <DistributedParameter id="clNAnnuymkOQkBxYUPRgEQ" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_rSwAhGUA0mX23LcfnDiSA" mode="Logical" isDefault="1">
+                        <Children>
+                          <Parameter id="Aj1h_dkeX02XG8G6esqC9Q" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="32" group="32" />
+                          </Parameter>
+                          <Parameter id="BkZj7VKkhUm3vPdzvverdw" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.5">
+                            <Info min="0" flag="50" seq="1" ref="0" bb="32" group="32" />
+                          </Parameter>
+                          <Container id="FMlLiuvdEUGsWxiSMjpLwg" name="Aciclovir" mode="Logical" containerType="Molecule" />
+                        </Children>
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="122" seq="1" ref="0" bb="32" group="32" />
+                      </DistributedParameter>
+                      <MoleculeAmount id="6TBsmIsgAUuGo89J6jBkvQ" name="CYP344" icon="ENZYME" persistable="0" isFixedValue="0" dim="Amount" quantityType="Enzyme" negativeValuesAllowed="0" formula="rMXLZglcaUaofPZ0c6I6Yw" mode="Logical" scaleDivisor="1" displayUnit="µmol">
+                        <Children>
+                          <Parameter id="UqbO1o0p-UeO0F3M1rbXpA" name="Degradation coefficient" description="First order turnover rate constant of the enzyme" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="c2fNMePAyki4XPdR-AEHaQ" isDefault="1" displayUnit="1/min">
+                            <ValueOrigin id="33" source="Other" description="OSP Suite Manual Chapter 16. PK-Sim®- Compounds: Defining inhibition/induction processes" />
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="pfiaMGq6R06Hxovui7Dgyw" name="Relative expression" description="Relative expression" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0">
+                            <Info min="0" flag="60" seq="1" ref="0" bb="32" group="91" />
+                          </Parameter>
+                          <Parameter id="wLqQXNlu7kiA9Jg9o6PbDg" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0">
+                            <Info min="0" flag="58" seq="1" ref="0" bb="32" group="91" />
+                          </Parameter>
+                          <Parameter id="zxVDQLxhnUSEeia59NdPjw" name="Relative expression out." description="Relative Expression that will be used in the simulation" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="fbRCNZOks0i0JlaOaYnbvg" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="KdN3_n8iUU6ydKbvfVT-Gg" name="Start amount" description="Start amount of molecule" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" formula="EPX-QNxBZE2pcwiBNY6NfA" isDefault="1" displayUnit="µmol">
+                            <Info flag="54" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="IBMwaxaBd0OQxVv0wdULQg" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="_5AQF4X5mkuTWnIB24ghvw" isDefault="1" displayUnit="µmol/l">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Parameter id="Wz7Qk7o1vUezDIb92s0h8Q" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="PmypJ-FmP0eWnyDu0WP17g" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                          </Parameter>
+                          <Parameter id="6PfMOWvOyEOTxEVNa50-VQ" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="ZeKpmEyTBk6KdlUDIhYBug" isDefault="1" displayUnit="min">
+                            <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                        </Children>
+                      </MoleculeAmount>
+                      <MoleculeAmount id="Q5OEj64gBkqtBIJ7GLeeGw" name="Aciclovir" icon="DRUG" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" negativeValuesAllowed="0" mode="Logical" scaleDivisor="1" value="0" displayUnit="µmol">
+                        <Children>
+                          <Parameter id="Qku-C2yKR0O0hiaZLU2WHQ" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="_5AQF4X5mkuTWnIB24ghvw" isDefault="1" displayUnit="µmol/l">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Parameter id="vKFLWREFDkuJdJ7M_Qx08w" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" rHSFormula="aYU_LcDzqE2wt9LVzolUFQ" value="0" displayUnit="µmol">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Parameter id="6CO4Sh6PrEmMSaMGo0UkaQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                          </Parameter>
+                          <Parameter id="v8K_zGQ8aES2_vyWqAPbWA" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="NI8i9V3S80aiGBr6zhr9WQ" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="FCXlk0EbU0eKw8K_-eNlzQ" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Hl8fg17VjE-kWGF7qqoeWw" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="6ewDNUx6MUKsVDiePh09ug" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="5aKJzW5Q_0apTR5tAjGlag" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="1fujBz5uQ0-knXvAWXZ1wg" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="579xa75K906h_sJ2igUNcQ" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="O0U3uuXOXE-1jG7c4qlYzw" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="s_IvxGIb3UmmsYjvRtd5sw" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="fsTpmSnkckqdXzfBUJbULw" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="-N6kx_fL3kqa6MMP8w7VHg" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="2GmsHrBA4U-vd1OvF-jssw" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="zDyoICz-NkS-VsjajsbZ_Q" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="t_t2efS1o06XPX4kRvA6NQ" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="LpMNuW7uQ0-E53D7tYKFSQ" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="yu1hl1jCWEiY4uGTOpb5zQ" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="PM1uAQEEG0G1RcF9xFsxGA" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="JqmJ-K1MAEGcdY-kVzZaIQ" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="kECoLaiGlkaolugEtdf9Lw" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="G575y7vMvE2bR4PkvxKjPQ" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="K-HVNjIbzUCS_eDFkDs9lw" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="0lQ-IPen60iZxNUZmiuAYw" name="Solubility" description="Solubility" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="etug4sJXNkmb8hkObMnBEw" isDefault="1" displayUnit="mg/l">
+                            <Info min="0" flag="122" seq="1" ref="0" bb="2" group="42" />
+                          </Parameter>
+                          <Parameter id="UC6Raua51UCGJznGE2ftmw" name="Solubility table" description="Solubility table" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="I2x998FYXUG8Fkag8eBK1Q" isDefault="1" displayUnit="mg/l">
+                            <Info min="0" flag="50" seq="1" ref="0" bb="2" group="42" />
+                          </Parameter>
+                          <Parameter id="M8MomccsiU-jSbmwvpsQIA" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="KBkQftbxeECDixj1vtX_MQ" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="aCaB7q69m0WwTLVM0C8C0w" name="Effective concentration in lumen" description="In case of supersaturation: molecule amount divided by liquid volume. Otherwise: Min(intestinal solubility; molecule amount divided by liquid volume)." icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="Dn0HT2rRDEO8NDxyMCfong" isDefault="1" displayUnit="µmol/l">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="42" />
+                          </Parameter>
+                          <Observer id="k3AQU3-Dik-8NWsGycEpXw" name="Concentration in lumen" description="Concentration of the molecule in lumen" icon="Observer" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" negativeValuesAllowed="1" formula="SEsNpt8BTUG8roHXWpFOQA" displayUnit="µmol/l" />
+                          <Observer id="ajA_iNlmyUSY7sKNNoci2g" name="Fraction of oral drug mass absorbed into mucosa segment" description="Fraction of oral drug mass absorbed into mucosa segment" icon="Observer" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Drug, Observer" negativeValuesAllowed="1" formula="r43vCSc7BEe5-dGA5yh3BA" />
+                        </Children>
+                      </MoleculeAmount>
+                    </Children>
+                  </Container>
+                  <Container id="V5WMpuj5yEWwcXqu6PUWjQ" name="ColonDescendens" description="Colon Descendens / Distal Colon 1" icon="ColonDescendens" mode="Physical" containerType="Compartment">
+                    <Tags>
+                      <Tag value="Lumen" />
+                      <Tag value="LumenSegment" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="RzKKXyPOr0S7-0K_kL_PAQ" name="Absorption of liquid" description="rate of liquid outflow" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="z6DMPvJEE0yt3wWmk5Z3Ow" isDefault="1" displayUnit="1/min">
+                        <Info flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="kwDVlllh_0G1DhVTunqUCA" name="Distal radius" description="Distal radius of intestinal segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="qN0sQEkpKUSNvqPOFISgPQ" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="IV9etd6SfkyAT3dGFUrGCA" name="Effective surface area" description="Effective surface area of GI segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="UDKQRMZb0kGECYiG1jVLSA" isDefault="1" displayUnit="cm²">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
+                        <Info min="0" flag="52" seq="1" ref="0" bb="32" group="33" />
+                      </Parameter>
+                      <Parameter id="AYIGrUYfCUaliInAMli_kg" name="FillLevelFlag" description="Fill Level Flag" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="GLqHpG_OJkWM8l0SHiAa5g" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="CTeRnnkuMEqApk4rnbbWFA" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="aVy7eAeHjE6ETh8kdqeSuQ" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="LTXAXiCfYUSGyP5G1Cpriw" name="Geometric surface area" description="Geometric surface area of GI segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="wsKEN3Lx60Ku0hovyuGDqw" isDefault="1" displayUnit="cm²">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="62" seq="1" ref="0" bb="32" group="33" />
+                      </Parameter>
+                      <Parameter id="FR7qvSM_90OnlDLJKDnA5g" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="T7FD5neESUmrf3t9GHIqyQ" isDefault="1" displayUnit="1/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="D0Mhx96DUUqn_Y5SIrgwoA" name="Length" description="Length" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="sIXkaS02_UGII5sFXg9TKg" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="106" seq="1" ref="0" bb="32" group="34" />
+                      </Parameter>
+                      <Parameter id="ImR1S8U8IEyIVEfmDZcN-A" name="Liquid" description="Liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="DxFS8aU9SUGHF72wLzZs7A" isDefault="1" rHSFormula="im1Nd61hXUakCoFwBfHKfA" displayUnit="l">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="mcojCg_hQ0yzQgklCWPqYA" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="xFK5mt1aL0yUDl5xUlalug" isDefault="1" displayUnit="l/min">
+                        <Info flag="52" seq="1" ref="0" bb="2" group="39" />
+                      </Parameter>
+                      <Parameter id="obePmeqc6Emh8iCnMxMAsA" name="Proximal radius" description="Proximal radius of intestinal segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="FyJ0mmQ3tkGYaA3eL3fCSg" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="YzVZNWWutUexjANbj-SrNA" name="Secretion of liquid" description="Rate of liquid inflow" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="pPHRUtVHy0a5TYGLeTJ0Lw" isDefault="1" displayUnit="l/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="4h8wGT4hUkeYE3gL7iKjrQ" name="Thickness of gut wall" description="Thickness of Gut Wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="JHk9xtQ6YUWAs-vav0AWPg" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="38" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <Parameter id="6VRZZqcb1E29nwacyTEiAQ" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="v0bWMujBVUKTXasj7lfskg" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="62" seq="1" ref="0" bb="2" group="56" />
+                      </Parameter>
+                      <Parameter id="wDbMF1m8XUqMG3qJ6D51rg" name="Volume (gut wall)" description="Volume of the gut wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="RmIs70JWlEys4njJ5LY_JQ" isDefault="1" displayUnit="l">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="62" seq="1" ref="0" bb="32" group="44" />
+                      </Parameter>
+                      <Parameter id="rbN4i4VAqE-lKfthBP6_Ow" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="WiDWMA7xi02WdVvl1Rjr0g" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="kBSGBgtrUkSZCM50HNBLsQ" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0060009">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="58" seq="1" ref="0" bb="32" group="43" />
+                      </Parameter>
+                      <Parameter id="HGWrRRVoc0yzv8T-N8pZnw" name="Intestinal transit rate" description="Transit rate along intestinal segments" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="5" displayUnit="1/min">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="54" seq="1" ref="0" bb="32" group="46" />
+                      </Parameter>
+                      <Parameter id="7rqCmD5nK0uCXtNi8IgawQ" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.4227543951" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="34" />
+                      </Parameter>
+                      <Parameter id="g6YfvYZvG0-ZVor99QQycQ" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.098514277">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="34" />
+                      </Parameter>
+                      <Parameter id="6hLmqM9yG0iV0ZuMuX1WJA" name="Microvilli factor" description="Microvilli factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="38" seq="1" ref="0" bb="32" group="33" />
+                      </Parameter>
+                      <Parameter id="53VB74h760q1g3H1pDLx6g" name="pH" description="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="6.6">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
+                        <Info min="0" max="14" flag="122" seq="1" ref="0" bb="32" group="41" />
+                      </Parameter>
+                      <Parameter id="fcN0jfAI5EO0lG3p4htNmA" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0384322177" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="S-ElcBFo40u57yDQnW02Ug" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.008955843">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="Y_lHavzp6UWfrWleabd2cw" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0384322177" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="1txmxGAT2kCX9pdQGYnVJg" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.008955843">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="yBvZJSseiUed5r8hV4PpRw" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0118" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <Parameter id="JFFRxFWB4Ei7VpRDQ2rN7g" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0601543776" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <Parameter id="dW_vE5RX20aiDLY16SmJxQ" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.08977747" displayUnit="1/cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <DistributedParameter id="kl_GML_uhE-lz2ulDOrSqQ" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="mJZ8kcL1CkqBR-tJ8nkpkw" mode="Logical" isDefault="1">
+                        <Children>
+                          <Parameter id="JxXEZLbxwEubXg78tbKPzQ" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="32" group="32" />
+                          </Parameter>
+                          <Parameter id="wlNm8frKxEuu2Q55WwaVEQ" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.5">
+                            <Info min="0" flag="50" seq="1" ref="0" bb="32" group="32" />
+                          </Parameter>
+                          <Container id="gt7nVrvzp0GV4UiUcifnAw" name="Aciclovir" mode="Logical" containerType="Molecule" />
+                        </Children>
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="122" seq="1" ref="0" bb="32" group="32" />
+                      </DistributedParameter>
+                      <MoleculeAmount id="o8Civ3UJJ0SihvqATv7GyQ" name="CYP344" icon="ENZYME" persistable="0" isFixedValue="0" dim="Amount" quantityType="Enzyme" negativeValuesAllowed="0" formula="rMXLZglcaUaofPZ0c6I6Yw" mode="Logical" scaleDivisor="1" displayUnit="µmol">
+                        <Children>
+                          <Parameter id="UXQrGk9Alkaddsq3K054Cw" name="Degradation coefficient" description="First order turnover rate constant of the enzyme" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="c2fNMePAyki4XPdR-AEHaQ" isDefault="1" displayUnit="1/min">
+                            <ValueOrigin id="33" source="Other" description="OSP Suite Manual Chapter 16. PK-Sim®- Compounds: Defining inhibition/induction processes" />
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="oIZjGs9UMECvWAtbXEo7nQ" name="Relative expression" description="Relative expression" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0">
+                            <Info min="0" flag="60" seq="1" ref="0" bb="32" group="91" />
+                          </Parameter>
+                          <Parameter id="K5z8p0RX9kSLZGEi9pL4iQ" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0">
+                            <Info min="0" flag="58" seq="1" ref="0" bb="32" group="91" />
+                          </Parameter>
+                          <Parameter id="HEZ2mo6WUEWMiXJKDUXmQg" name="Relative expression out." description="Relative Expression that will be used in the simulation" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="fbRCNZOks0i0JlaOaYnbvg" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="r6wnRscrpEqxf_Zu4Z1eJw" name="Start amount" description="Start amount of molecule" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" formula="EPX-QNxBZE2pcwiBNY6NfA" isDefault="1" displayUnit="µmol">
+                            <Info flag="54" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="cWqQQ-LBgku4bLi2_7vKzA" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="_5AQF4X5mkuTWnIB24ghvw" isDefault="1" displayUnit="µmol/l">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Parameter id="U5dw8aII4kq-bFZDThLpVw" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="4egBLK8jdE66PIpuw6QOGg" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                          </Parameter>
+                          <Parameter id="iugyAIY3AkSnfpdWs5ZXYw" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="JiOTVtuVkEan1LlVl4zGUw" isDefault="1" displayUnit="min">
+                            <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                        </Children>
+                      </MoleculeAmount>
+                      <MoleculeAmount id="C6DyIFKpeEmKqHkrCOLznw" name="Aciclovir" icon="DRUG" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" negativeValuesAllowed="0" mode="Logical" scaleDivisor="1" value="0" displayUnit="µmol">
+                        <Children>
+                          <Parameter id="Y7R4hFC4SEizNUOWEtcjsw" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="_5AQF4X5mkuTWnIB24ghvw" isDefault="1" displayUnit="µmol/l">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Parameter id="hOCD87DMPEyQmid_bPvUgA" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" rHSFormula="bd9Z31mg00-B3-RykIqLgQ" value="0" displayUnit="µmol">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Parameter id="i2FAP5sw70WPHIm6yakItA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                          </Parameter>
+                          <Parameter id="Am2ypQ81mku03TDI_nBJGA" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="WQA-CXyfQkyiTsTPI0Afug" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="4DJUEEvOQ0q2YiQWe3Ntug" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="W9j0rYe-dE6-AL63spcfrg" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="3XTS_R_jfECeNKcG03dWRA" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="JA3IwyTzrUO6yjPdLIbLuw" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="ebo5tgC5d0WOkYDO-01bug" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="VrqrTPt1Y0G_aouAF2uGwA" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="EkS0geaoGkONpcZK4mEJjQ" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="3xFcwksRg0SI9gTluTRYXg" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="2UG1Il_1fkSb1dd8EkcSXA" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BzSJNF-Hj06-hMyV2pIRcA" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="cknKIefjKk6CHslTf1l__w" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="VsTu1nJsNkmtIR3HHJWeWQ" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="4mDII4XP80OOaqyBNXTOCQ" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="WtspV7jQekO-CaQR61PIdA" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="f5scs0u9DUOS9Hl0cTJJmA" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="kfpPzdxXMkyGvLUHZzYRzg" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="9ULngTVQ00qHhOn8wnlHBg" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ekIXhyBJA0WhBbHJIjeNOQ" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="sjRLThGXuEaZh0SmiRFTcg" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="8eTxYDpe706iPlkWYWKvLQ" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="SB9WgCLT-0qVj9X82QNNsQ" name="Solubility" description="Solubility" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="oeoeoNsj4kaHDKLkmhcufw" isDefault="1" displayUnit="mg/l">
+                            <Info min="0" flag="122" seq="1" ref="0" bb="2" group="42" />
+                          </Parameter>
+                          <Parameter id="aF1FcpieZEuE71hyEegeHw" name="Solubility table" description="Solubility table" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="FQB3KG0NPk-rDDw7OzGZeg" isDefault="1" displayUnit="mg/l">
+                            <Info min="0" flag="50" seq="1" ref="0" bb="2" group="42" />
+                          </Parameter>
+                          <Parameter id="oiXZG54BuUSSsJRdpstXNw" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="VB8OKCgjgk6INOgYO4Q6ng" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="jr7LjuyYK0mhRu9A3f82iA" name="Effective concentration in lumen" description="In case of supersaturation: molecule amount divided by liquid volume. Otherwise: Min(intestinal solubility; molecule amount divided by liquid volume)." icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="_-Xw1XYOak6LzYdFohyBhQ" isDefault="1" displayUnit="µmol/l">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="42" />
+                          </Parameter>
+                          <Observer id="JJsE2AcOWkem7n1m_8G3FQ" name="Concentration in lumen" description="Concentration of the molecule in lumen" icon="Observer" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" negativeValuesAllowed="1" formula="SEsNpt8BTUG8roHXWpFOQA" displayUnit="µmol/l" />
+                          <Observer id="Q4k8PmDqGUeqIz-6UwijHw" name="Fraction of oral drug mass absorbed into mucosa segment" description="Fraction of oral drug mass absorbed into mucosa segment" icon="Observer" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Drug, Observer" negativeValuesAllowed="1" formula="r43vCSc7BEe5-dGA5yh3BA" />
+                        </Children>
+                      </MoleculeAmount>
+                    </Children>
+                  </Container>
+                  <Container id="QrFcARY080K42hhS9X8Hvg" name="ColonSigmoid" description="Colon Sigmoid / Distal Colon 2" icon="ColonSigmoid" mode="Physical" containerType="Compartment">
+                    <Tags>
+                      <Tag value="Lumen" />
+                      <Tag value="LumenSegment" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="WzXbdoLXMUC_msHT2egj8w" name="Absorption of liquid" description="rate of liquid outflow" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="uLW2lzHpjkqdsRO9ZZui_A" isDefault="1" displayUnit="1/min">
+                        <Info flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="hsnmfkQAZEy4CcS2q9S84w" name="Distal radius" description="Distal radius of intestinal segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="qN0sQEkpKUSNvqPOFISgPQ" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="rG1NSAcETE2DVQm_NapKdw" name="Effective surface area" description="Effective surface area of GI segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="UDKQRMZb0kGECYiG1jVLSA" isDefault="1" displayUnit="cm²">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
+                        <Info min="0" flag="52" seq="1" ref="0" bb="32" group="33" />
+                      </Parameter>
+                      <Parameter id="t73lyHD7VE2pYKBvMj4gfw" name="FillLevelFlag" description="Fill Level Flag" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="GLqHpG_OJkWM8l0SHiAa5g" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="2-EI7GPQWkK1qNkTOcwg5Q" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="aVy7eAeHjE6ETh8kdqeSuQ" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="7e8YJxm8ZkiwRmHWRc2bjA" name="Geometric surface area" description="Geometric surface area of GI segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="wsKEN3Lx60Ku0hovyuGDqw" isDefault="1" displayUnit="cm²">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="62" seq="1" ref="0" bb="32" group="33" />
+                      </Parameter>
+                      <Parameter id="uoKDrsdqZE2Dr9THZGLRqQ" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="HbACTiQqBUixeSXwqyzNlg" isDefault="1" displayUnit="1/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="XVimFuh7b0-cnPmz0xRLNg" name="Length" description="Length" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="sIXkaS02_UGII5sFXg9TKg" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="106" seq="1" ref="0" bb="32" group="34" />
+                      </Parameter>
+                      <Parameter id="Pm8vUa8bqEeGT6u7rZ9XiA" name="Liquid" description="Liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="DxFS8aU9SUGHF72wLzZs7A" isDefault="1" rHSFormula="GYHrwHf5O0WtwcgUaEvO-g" displayUnit="l">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="nbBUHEdSIUG1EdPS_CbqJw" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="MfUGr1xSWkK9twTf2dKAEw" isDefault="1" displayUnit="l/min">
+                        <Info flag="52" seq="1" ref="0" bb="2" group="39" />
+                      </Parameter>
+                      <Parameter id="qA-xDrb4qkeNt-ngKxkmSA" name="Proximal radius" description="Proximal radius of intestinal segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="FyJ0mmQ3tkGYaA3eL3fCSg" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="z5U1Y46GKEKQ0ZnFoUa17w" name="Secretion of liquid" description="Rate of liquid inflow" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="MDh-h21DFkSJKUTcDId5YQ" isDefault="1" displayUnit="l/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="o8x9xdoNjkCFDuaen_wgYw" name="Thickness of gut wall" description="Thickness of Gut Wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="JHk9xtQ6YUWAs-vav0AWPg" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="38" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <Parameter id="Sbtd8agYcUy_9aM0vK_wPw" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="v0bWMujBVUKTXasj7lfskg" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="62" seq="1" ref="0" bb="2" group="56" />
+                      </Parameter>
+                      <Parameter id="hwRyUmLXckuywIpNQQPe0w" name="Volume (gut wall)" description="Volume of the gut wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="2hYl4u0EsEKJTldOxyvj9g" isDefault="1" displayUnit="l">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="62" seq="1" ref="0" bb="32" group="44" />
+                      </Parameter>
+                      <Parameter id="wFrs3mcocUaV9v3cqqSdvA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="WiDWMA7xi02WdVvl1Rjr0g" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="GZT7WXKKKk6ZH_KBZbt9dw" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0060009">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="58" seq="1" ref="0" bb="32" group="43" />
+                      </Parameter>
+                      <Parameter id="ZMoEJ5mfqketR8tt_3Ap4Q" name="Intestinal transit rate" description="Transit rate along intestinal segments" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="4.0741" displayUnit="1/min">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="54" seq="1" ref="0" bb="32" group="46" />
+                      </Parameter>
+                      <Parameter id="PX4SWpqozkSRP22tgHSqkw" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5337898629" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="34" />
+                      </Parameter>
+                      <Parameter id="ly2EGbActk60YDzXDP7_Rg" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.121300709">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="34" />
+                      </Parameter>
+                      <Parameter id="G1CYGSdylkmIA8pYB-18EQ" name="Microvilli factor" description="Microvilli factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="38" seq="1" ref="0" bb="32" group="33" />
+                      </Parameter>
+                      <Parameter id="WgR8wY_7Y0GNA0Xo10l9VA" name="pH" description="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="6.6">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
+                        <Info min="0" max="14" flag="122" seq="1" ref="0" bb="32" group="41" />
+                      </Parameter>
+                      <Parameter id="u3tnWpoSF0SH0bn9aVPV4A" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0384322177" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="8NWVbMsnK0mGOR5Zpa2iqg" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.008955843">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="2nhw63xGR0WE021RJKyU7A" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0384322177" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="Hk2No0S_-ES-OGHLlWO1aQ" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.008955843">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="NlvkfbPcxE-b3WD0Yr8CLQ" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.00536" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <Parameter id="if8wIYaYzkSvODq4-xSr2w" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0274432593" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <Parameter id="Yi3rTFT_mU6qLKmNiImscw" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.0889014" displayUnit="1/cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <DistributedParameter id="3rt2nX-orEqne7KCFomMPQ" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="UsYNUx_YFkGyJ2_OfRm7jw" mode="Logical" isDefault="1">
+                        <Children>
+                          <Parameter id="9806mCP3jUi6Q3NCPsqSxg" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="32" group="32" />
+                          </Parameter>
+                          <Parameter id="hwJZPWz26EuCCTR31Q2cAg" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.5">
+                            <Info min="0" flag="50" seq="1" ref="0" bb="32" group="32" />
+                          </Parameter>
+                          <Container id="l_gtqw0gYkm-CayTSyrcrg" name="Aciclovir" mode="Logical" containerType="Molecule" />
+                        </Children>
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="122" seq="1" ref="0" bb="32" group="32" />
+                      </DistributedParameter>
+                      <MoleculeAmount id="tQXRSlNP3E66XPOzaojNeQ" name="CYP344" icon="ENZYME" persistable="0" isFixedValue="0" dim="Amount" quantityType="Enzyme" negativeValuesAllowed="0" formula="rMXLZglcaUaofPZ0c6I6Yw" mode="Logical" scaleDivisor="1" displayUnit="µmol">
+                        <Children>
+                          <Parameter id="-weARV4KOkaCaMnUPVgpCA" name="Degradation coefficient" description="First order turnover rate constant of the enzyme" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="c2fNMePAyki4XPdR-AEHaQ" isDefault="1" displayUnit="1/min">
+                            <ValueOrigin id="33" source="Other" description="OSP Suite Manual Chapter 16. PK-Sim®- Compounds: Defining inhibition/induction processes" />
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="mxiOXjpM8EeY7DAL2aqFWQ" name="Relative expression" description="Relative expression" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0">
+                            <Info min="0" flag="60" seq="1" ref="0" bb="32" group="91" />
+                          </Parameter>
+                          <Parameter id="XloUiWbx1k69hTlLrldbgg" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0">
+                            <Info min="0" flag="58" seq="1" ref="0" bb="32" group="91" />
+                          </Parameter>
+                          <Parameter id="MXCZnood_EubV3mTk5xGPw" name="Relative expression out." description="Relative Expression that will be used in the simulation" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="fbRCNZOks0i0JlaOaYnbvg" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="Vt9E6awBok6HyaNBTu0flw" name="Start amount" description="Start amount of molecule" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" formula="EPX-QNxBZE2pcwiBNY6NfA" isDefault="1" displayUnit="µmol">
+                            <Info flag="54" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="F1xQnBLKkECbCL_6IuboiA" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="_5AQF4X5mkuTWnIB24ghvw" isDefault="1" displayUnit="µmol/l">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Parameter id="W_mdsDnYx0mX3vtxOtFdzA" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="UmddK034QUaavyPjyTE5FQ" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                          </Parameter>
+                          <Parameter id="Oz8OZHrDzkeE2Void_-q4g" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="GF1RDIrPnUKUvRnUgRGbpg" isDefault="1" displayUnit="min">
+                            <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                        </Children>
+                      </MoleculeAmount>
+                      <MoleculeAmount id="Fza7BQhGyUqFqjma1_gXAQ" name="Aciclovir" icon="DRUG" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" negativeValuesAllowed="0" mode="Logical" scaleDivisor="1" value="0" displayUnit="µmol">
+                        <Children>
+                          <Parameter id="5_Szik5jgkS7cjI_gLZsRA" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="_5AQF4X5mkuTWnIB24ghvw" isDefault="1" displayUnit="µmol/l">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Parameter id="5u1ShcYSqUaXHoaRaxb3qA" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" rHSFormula="w7PRghP-WEKa46kiKisnBg" value="0" displayUnit="µmol">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Parameter id="SV0LreCcIEKZILveTyyo3w" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                          </Parameter>
+                          <Parameter id="E2M2FvsLdEmCLr4LNoRP4A" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="EMbC4m_-70a62l5kgLbNyA" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="-PdLKK8o90aOftmeVAaVYA" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="N55HfiPLlEOA1uQuNUUx7g" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="Yf6oK2wwD0eUzW_gHuvA8g" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Wu0WiJ0dsUemWa7aJc9UfA" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="zb_FaI7AAE-aiPvu-6fqGA" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="HFjOVJBAs0mdpMOoOax2Cg" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="PDsEjhcjgkG0S1XQLG2wcA" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="8a8GbecpkkiNyeKGET99Lw" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="531zucO65UOsi_dndiuZGA" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="nilMYgtgpk-eLHWOgQh52w" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="UM52vy7wdEGebq08yqpm1w" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="fCj0d4zvikOb8GvRxXV6Xw" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="x2csWTwls0Whqk-LGzboEQ" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="fZiIciCinEq37MeOZRCvsw" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="Nt4xktHIJE2G8TFoz5wBWw" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="RZ0YXyMq50u5mFeWml33Ww" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="8nGECJJER0eVonCeoOsfmg" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="P8F6lv9AEkOxZ8THXv8wVw" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="wKDbD4FNDUeXDO0rFDXbFQ" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="xbWQlW_EekKEQ9yY_RGfUA" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="AL5p0Qkni06EYzbAvKKkyQ" name="Solubility" description="Solubility" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="CStaDCQJ6k-aecTvU2zJ2w" isDefault="1" displayUnit="mg/l">
+                            <Info min="0" flag="122" seq="1" ref="0" bb="2" group="42" />
+                          </Parameter>
+                          <Parameter id="IQ1AkibjZEqN_oH1SFvg2A" name="Solubility table" description="Solubility table" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="xF7hn9xEEUWGOOr-0Ci8ng" isDefault="1" displayUnit="mg/l">
+                            <Info min="0" flag="50" seq="1" ref="0" bb="2" group="42" />
+                          </Parameter>
+                          <Parameter id="H1WikjlGAUKdCWI1bDiqiA" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="meItW9eWZkOmPkBa4pnxLg" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="BjrkffsW90eRGczOhB0t-A" name="Effective concentration in lumen" description="In case of supersaturation: molecule amount divided by liquid volume. Otherwise: Min(intestinal solubility; molecule amount divided by liquid volume)." icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="HlBOaSfvE0-J0iRQoLPMng" isDefault="1" displayUnit="µmol/l">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="42" />
+                          </Parameter>
+                          <Observer id="jBiAUM5y9keDJy7lASRsMA" name="Concentration in lumen" description="Concentration of the molecule in lumen" icon="Observer" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" negativeValuesAllowed="1" formula="SEsNpt8BTUG8roHXWpFOQA" displayUnit="µmol/l" />
+                          <Observer id="XY1wv_t0mEy-IckoDkudNw" name="Fraction of oral drug mass absorbed into mucosa segment" description="Fraction of oral drug mass absorbed into mucosa segment" icon="Observer" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Drug, Observer" negativeValuesAllowed="1" formula="r43vCSc7BEe5-dGA5yh3BA" />
+                        </Children>
+                      </MoleculeAmount>
+                    </Children>
+                  </Container>
+                  <Container id="jUxouOhem0ep-Qu6MPS_aw" name="Rectum" description="Rectum" icon="Rectum" mode="Physical" containerType="Compartment">
+                    <Tags>
+                      <Tag value="Lumen" />
+                      <Tag value="LumenSegment" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="WoSO6mkuZkS_Ywo5beHB2w" name="Absorption of liquid" description="rate of liquid outflow" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="FLe2C-RC8UujwJ_K5EwNwQ" isDefault="1" displayUnit="1/min">
+                        <Info flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="4_v93R4Ba06U8F8KXOgjhA" name="Distal radius" description="Distal radius of intestinal segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="qN0sQEkpKUSNvqPOFISgPQ" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="zUFvtTQ1Tky-DCZFnqKNZg" name="Effective surface area" description="Effective surface area of GI segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="UDKQRMZb0kGECYiG1jVLSA" isDefault="1" displayUnit="cm²">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
+                        <Info min="0" flag="52" seq="1" ref="0" bb="32" group="33" />
+                      </Parameter>
+                      <Parameter id="Z_PAFy8udEWiynrHa1rG9A" name="FillLevelFlag" description="Fill Level Flag" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="GLqHpG_OJkWM8l0SHiAa5g" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="sX8LwGdjR0mlMi_inR7hEA" name="Fraction of geometric volume filled with liquid" description="Geometric filling fraction" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="aVy7eAeHjE6ETh8kdqeSuQ" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="RzM58fRzIk68jtBiXT-cxQ" name="Geometric surface area" description="Geometric surface area of GI segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="wsKEN3Lx60Ku0hovyuGDqw" isDefault="1" displayUnit="cm²">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="62" seq="1" ref="0" bb="32" group="33" />
+                      </Parameter>
+                      <Parameter id="uv1lQQS0M0W9hIG0c8NT5A" name="Intestinal transit rate (absolute)" description="Transport rate to next GI segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="dj7tfHdVpEKUnXprvZVhwA" isDefault="1" displayUnit="1/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="v4d9QJ1IkUGpFimMPW1a1A" name="Length" description="Length" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="sIXkaS02_UGII5sFXg9TKg" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="106" seq="1" ref="0" bb="32" group="34" />
+                      </Parameter>
+                      <Parameter id="zqhSL_V00E20YGUOOsP5fA" name="Liquid" description="Liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="DxFS8aU9SUGHF72wLzZs7A" isDefault="1" rHSFormula="QMH4Fx11tk2mNjk3ZAnpSA" displayUnit="l">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="_OjVUtzweU6MPGbgOLO0JA" name="Liquid transfer rate" description="Rate of liquid transfer between lumen segments" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="Etxw2iBMGk2eBqOTZm8b5g" isDefault="1" displayUnit="l/min">
+                        <Info flag="52" seq="1" ref="0" bb="2" group="39" />
+                      </Parameter>
+                      <Parameter id="glu0hyEv3EypVd8ls8OKTQ" name="Proximal radius" description="Proximal radius of intestinal segment" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="FyJ0mmQ3tkGYaA3eL3fCSg" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="106" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="A838yKj4Ek29SDLciRGTug" name="Secretion of liquid" description="Rate of liquid inflow" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="J9bImQ6fF0C5OQAtucDxCg" isDefault="1" displayUnit="l/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="nEOCklGs_kSebshnD7XqiA" name="Thickness of gut wall" description="Thickness of Gut Wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="JHk9xtQ6YUWAs-vav0AWPg" isDefault="1" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="38" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <Parameter id="0WbZcpT7cU6yF1DnT6H6XQ" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="v0bWMujBVUKTXasj7lfskg" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="62" seq="1" ref="0" bb="2" group="56" />
+                      </Parameter>
+                      <Parameter id="rGizJvqA9kacGXxbPMO_MQ" name="Volume (gut wall)" description="Volume of the gut wall" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="Hv6s8y5NXU-CmlQDdjJUng" isDefault="1" displayUnit="l">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="62" seq="1" ref="0" bb="32" group="44" />
+                      </Parameter>
+                      <Parameter id="sPDXzVBb40O08okXpa1Eeg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="WiDWMA7xi02WdVvl1Rjr0g" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="dH9xrm5WeE27R27QjR_cAA" name="Fractional steady state fill level" description="Fractional steady state fill level in fasted state" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0060009">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="58" seq="1" ref="0" bb="32" group="43" />
+                      </Parameter>
+                      <Parameter id="GN-GuCRHzkKbIiYO3Xi-AA" name="Intestinal transit rate" description="Transit rate along intestinal segments" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="315.618" displayUnit="1/min">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="54" seq="1" ref="0" bb="32" group="46" />
+                      </Parameter>
+                      <Parameter id="IBkpvURbc0i--Et-wv3DSQ" name="L_p0" description="Parameter to calculate the length of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.1569046761" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="34" />
+                      </Parameter>
+                      <Parameter id="R5QpjSP_4UepfhQ167i1bQ" name="L_p1" description="Parameter to calculate the length of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.052420808">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="34" />
+                      </Parameter>
+                      <Parameter id="NDfX4HjCmEWVTc8o_XXJ9Q" name="Microvilli factor" description="Microvilli factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="38" seq="1" ref="0" bb="32" group="33" />
+                      </Parameter>
+                      <Parameter id="45ct4j40CkaWu1HjOPYPmA" name="pH" description="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="6.6">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
+                        <Info min="0" max="14" flag="122" seq="1" ref="0" bb="32" group="41" />
+                      </Parameter>
+                      <Parameter id="PkJQ95RA5Ua3SHmEx3gY9A" name="r1_p0" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0384322177" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="CvT2raPgiUK1_gpG37g6Ew" name="r1_p1" description="Parameter to calculate the proximal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.008955843">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="78e1odW1SkqDsZCrsJUGtw" name="r2_p0" description="Parameter to calculate the distal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0240201361" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="ot6mfHKqokeBoJffd0026g" name="r2_p1" description="Parameter to calculate the distal radius of lumen segment depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.005597402">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="35" />
+                      </Parameter>
+                      <Parameter id="RlDJbv2zdkWpMOpVbxO37g" name="Thickness_p1" description="Parameter to calculate the thickness of gut wall depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.00665" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <Parameter id="0JcOuWxPb0Oz9cz0OF4Q6w" name="Thickness_p2" description="Parameter to calculate the thickness of gut wall depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0324721331" displayUnit="cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <Parameter id="Uz2Jb_lV4kumrBtNF82UMQ" name="Thickness_p3" description="Parameter to calculate the thickness of gut wall depending on the body height." icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-0.10014267" displayUnit="1/cm">
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info flag="54" seq="1" ref="0" bb="32" group="45" />
+                      </Parameter>
+                      <DistributedParameter id="RE1zAmVaUkCeZOhKH0iksw" name="Effective surface area enhancement factor" description="Enhancement factor for the calculation of the effective surface area" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="xu71VTKHzkWTbm3RzQiFRg" mode="Logical" isDefault="1">
+                        <Children>
+                          <Parameter id="onssJopAT0q-qScIrVvVqw" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="32" group="32" />
+                          </Parameter>
+                          <Parameter id="w6Nvk4zvlU-zASZt794ZZQ" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="3.56">
+                            <Info min="0" flag="50" seq="1" ref="0" bb="32" group="32" />
+                          </Parameter>
+                          <Container id="VPzZada8qEi8qSharpHZCA" name="Aciclovir" mode="Logical" containerType="Molecule" />
+                        </Children>
+                        <Tags>
+                          <Tag value="Lumen" />
+                          <Tag value="LumenSegment" />
+                        </Tags>
+                        <Info min="0" flag="122" seq="1" ref="0" bb="32" group="32" />
+                      </DistributedParameter>
+                      <MoleculeAmount id="UhStJqWoNk2X50m4t4izcg" name="CYP344" icon="ENZYME" persistable="0" isFixedValue="0" dim="Amount" quantityType="Enzyme" negativeValuesAllowed="0" formula="rMXLZglcaUaofPZ0c6I6Yw" mode="Logical" scaleDivisor="1" displayUnit="µmol">
+                        <Children>
+                          <Parameter id="JX56ktDTC0SFv-05gG_Ffg" name="Degradation coefficient" description="First order turnover rate constant of the enzyme" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="c2fNMePAyki4XPdR-AEHaQ" isDefault="1" displayUnit="1/min">
+                            <ValueOrigin id="33" source="Other" description="OSP Suite Manual Chapter 16. PK-Sim®- Compounds: Defining inhibition/induction processes" />
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="GEP_jEio806O4uq5rkw0bQ" name="Relative expression" description="Relative expression" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0">
+                            <Info min="0" flag="60" seq="1" ref="0" bb="32" group="91" />
+                          </Parameter>
+                          <Parameter id="sBDepLvcR0eesoOlsG0xNA" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0">
+                            <Info min="0" flag="58" seq="1" ref="0" bb="32" group="91" />
+                          </Parameter>
+                          <Parameter id="cGKInq8avUq8_i0PNZz_Jg" name="Relative expression out." description="Relative Expression that will be used in the simulation" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="fbRCNZOks0i0JlaOaYnbvg" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="IR7duZtB10mryvVcJ4peZw" name="Start amount" description="Start amount of molecule" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" formula="EPX-QNxBZE2pcwiBNY6NfA" isDefault="1" displayUnit="µmol">
+                            <Info flag="54" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="BblH81qQYkiqDGPMjaxAYg" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="_5AQF4X5mkuTWnIB24ghvw" isDefault="1" displayUnit="µmol/l">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Parameter id="VEoSs6FaWEqqrNLcZF5t-A" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="SsgZRrZ9DkKRSYzfp0hZFg" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                          </Parameter>
+                          <Parameter id="Yh9ygDgxb0WyzvkxGQCmHA" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="0VyzZNVVQUKEeZ5xj8z8Yg" isDefault="1" displayUnit="min">
+                            <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                        </Children>
+                      </MoleculeAmount>
+                      <MoleculeAmount id="jMO_rCAwBkWG0LU4CcM-ew" name="Aciclovir" icon="DRUG" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" negativeValuesAllowed="0" mode="Logical" scaleDivisor="1" value="0" displayUnit="µmol">
+                        <Children>
+                          <Parameter id="iSLiD6Dlv0uprNymTyM_CQ" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="_5AQF4X5mkuTWnIB24ghvw" isDefault="1" displayUnit="µmol/l">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Parameter id="lq-3L6onVkS2kdwnVo4yVw" name="Oral mass absorbed segment" description="Oral mass absorbed from Lumen segment into mucosa" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" rHSFormula="oOKWKzpp2USQhFaOwZIOow" value="0" displayUnit="µmol">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Parameter id="t_IAl4LZPEyQLJ9i7yLyKg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                          </Parameter>
+                          <Parameter id="NGQ0b3wCaEysxC0sONteQw" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="KKGq7hmqNE6eID8XXoxhmw" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="Nq5a3bZ8kEaz_YfkPMNWwA" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="WXbP3tS57EW1kaASY2fciQ" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="lcv8MYtCg0-45reNyvygeg" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="vpqCY3CysUakS3UFOnihLg" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="-ogrvOZzoUyKckPUKH6Ayg" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="3Y7zzYVLf0eSI82Mj76CUg" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="NvDhNVMIB02DjXZ2vpxwkg" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Q0147zDCPU2no9m_S4f9nQ" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="4t69Mlo-wE2c7GVH34_EEA" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="o3AHo2-RFkiN20DrUaWtpA" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="Y0uLY0u11UWPzA7wn_20eQ" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="-6VWWh9xl0G74FdXm016Kw" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="jsfvKn62RkiBI1dt4ipBXw" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="H7k9ETZRE0aJpuWh74y6vg" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="6xOcBUaAmEu8h5mx7YGtXQ" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="YlRDer3SJ06qDxYf9u8ZRw" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="J2iRWw7z2kO4hLnLKhWaCg" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DX6XUpz1NE-cbBzt-a1QLg" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="G3dNXDTWBUGSc01g4EOH7g" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Ni08PMKu3ECemSZ_fVlfeg" isDefault="1">
+                            <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="ukliExvBcUqCFHBtbnF4fA" name="Solubility" description="Solubility" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="E-gdCkMPdkK3xqA2lfoEGw" isDefault="1" displayUnit="mg/l">
+                            <Info min="0" flag="122" seq="1" ref="0" bb="2" group="42" />
+                          </Parameter>
+                          <Parameter id="I4Q9Dg0XS0O4K8Y54i3oRg" name="Solubility table" description="Solubility table" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" formula="i8VIYEYrqkKF2UIcFO1tvg" isDefault="1" displayUnit="mg/l">
+                            <Info min="0" flag="50" seq="1" ref="0" bb="2" group="42" />
+                          </Parameter>
+                          <Parameter id="Kv8ZJUvvrUeQF-G3HBYFuA" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="8GsX5evVmE6u8Ya3XaPFyg" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="18" />
+                          </Parameter>
+                          <Parameter id="V11ZUy2UHU6Hy5wK5vzHbQ" name="Effective concentration in lumen" description="In case of supersaturation: molecule amount divided by liquid volume. Otherwise: Min(intestinal solubility; molecule amount divided by liquid volume)." icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="DX_vBJxElEa7wE3s7XYsew" isDefault="1" displayUnit="µmol/l">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="42" />
+                          </Parameter>
+                          <Observer id="4CDa5V3x6UOKsDLiGCdFNw" name="Concentration in lumen" description="Concentration of the molecule in lumen" icon="Observer" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" negativeValuesAllowed="1" formula="SEsNpt8BTUG8roHXWpFOQA" displayUnit="µmol/l" />
+                          <Observer id="35_NaFhaVkagtQW-SuZAGQ" name="Fraction of oral drug mass absorbed into mucosa segment" description="Fraction of oral drug mass absorbed into mucosa segment" icon="Observer" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Drug, Observer" negativeValuesAllowed="1" formula="r43vCSc7BEe5-dGA5yh3BA" />
+                        </Children>
+                      </MoleculeAmount>
+                    </Children>
+                  </Container>
+                  <Container id="3aTpkWxuxEGmx-15pjzBvw" name="Feces" description="Feces compartment used to collect the fraction excreted of the compound from the instestinal wall into the gut lumen." mode="Physical" containerType="Compartment">
+                    <Tags>
+                      <Tag value="Lumen" />
+                      <Tag value="LumenSegment" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="aA6UcIbTtEG0iTIaT7j_4g" name="Liquid" description="Liquid" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" rHSFormula="B565V0KaykO6M1tmwlt71Q" value="0" displayUnit="l">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="63" />
+                      </Parameter>
+                      <Parameter id="FNyIkz2vPEOyMTjlOsM7Mw" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="l">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="56" />
+                      </Parameter>
+                      <MoleculeAmount id="tXiqJYw4vU2NkwVEuobrOQ" name="Aciclovir" icon="DRUG" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" negativeValuesAllowed="0" mode="Logical" scaleDivisor="1" value="0" displayUnit="µmol">
+                        <Children>
+                          <Parameter id="AvnUR6j7i0WoLrx66yh7xQ" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="_5AQF4X5mkuTWnIB24ghvw" isDefault="1" displayUnit="µmol/l">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Observer id="pMffN4KNyUGUjFSOeQCPjQ" name="Concentration in feces" description="Concentration in feces" icon="Observer" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" negativeValuesAllowed="1" formula="6wCmGaSt3UirOnRpXv6unA" displayUnit="µmol/l" />
+                          <Observer id="Xg9cknnNoEaePUGMuk1_kw" name="Fraction excreted to feces" icon="Observer" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Drug, Observer" negativeValuesAllowed="1" formula="NKbuJQQs1Eq--ZXLHtUMMw" />
+                        </Children>
+                      </MoleculeAmount>
+                    </Children>
+                  </Container>
+                  <Container id="c1qF4iluek2J-ulVwqgLkw" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Observer id="krGle5oiW0WxMidxWW5giA" name="Fraction dissolved" description="Dissolved fraction of all oral applications" icon="Observer" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Drug, Observer" negativeValuesAllowed="1" formula="t6DIoRZlB0S9NZlCsupLDA" />
+                      <Observer id="aQNdu7y2V06vzk12y5TRdQ" name="Fraction of oral drug mass absorbed into mucosa" description="Fraction of oral drug mass absorbed into mucosa" icon="Observer" persistable="1" isFixedValue="0" dim="Fraction" quantityType="Drug, Observer" negativeValuesAllowed="1" formula="jUMxR4yRl0GF2pTqX3J4dw" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Container>
+              <Container id="hyJ5Vhtpekyb5Oa7Z26GEA" name="Stomach" description="Stomach" icon="Stomach" mode="Logical" containerType="Organ">
+                <Tags>
+                  <Tag value="Portal Vein Supplying Organ" />
+                  <Tag value="TissueOrgan" />
+                </Tags>
+                <Children>
+                  <Parameter id="n2rjQ1UOrkOUKP1UiLlHYw" name="Weight (tissue)" description="Weight of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="fliUWazsPUiRy_qjzM6EaA" isDefault="1" displayUnit="kg">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
+                  </Parameter>
+                  <Parameter id="7tRpv6t6T0OEuqGSrzbFaQ" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="SEONXx9l8UekWRlG-vCS6A" isDefault="1" displayUnit="l/min">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="14" ref="0" bb="32" group="27" />
+                  </Parameter>
+                  <Parameter id="3TaF5uWik0e6W1a1yGpElg" name="Lymph flow rate" description="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="AHUOFh7VvEGdn9pbFbN0Ng" isDefault="1" displayUnit="l/min">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="14" ref="0" bb="32" group="58" />
+                  </Parameter>
+                  <Parameter id="ZE15J17Mpku0oezd79dv0g" name="Volume (endothelium)" description="Volume of  vascular endothelium" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="6FP0OGRZwkGE6KbxjPXbLg" isDefault="1" displayUnit="l">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="62" seq="14" ref="0" bb="32" group="127" />
+                  </Parameter>
+                  <Parameter id="BRGJEXMLnkCy5P0tKZgbYQ" name="Fraction intracellular" description="Fraction of intracellular space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="I-HZynBcWEaZVIcFkF3iMQ" isDefault="1">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="62" seq="43" ref="0" bb="32" group="64" />
+                  </Parameter>
+                  <Parameter id="AZfJbv7FikmQGnukBFgI9g" name="Blood flow rate" description="Organ blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="y6LwIbRu9ku8erXKf1RN9w" isDefault="1" displayUnit="l/min">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="48" source="Other" description="Absolute value = specific value (i.e. value normalized to the volume of the organ) multiplied by the organ volume" />
+                    <Info min="0" flag="62" seq="262" ref="0" bb="32" group="5" />
+                  </Parameter>
+                  <Parameter id="z3_aC_U6xUapB-ws1YrKxw" name="Density (tissue)" description="Density of tissue" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="38" seq="1" ref="0" bb="32" group="21" />
+                  </Parameter>
+                  <Parameter id="hkAo3f6TzESZ2KsuRyRlSA" name="Fluid recirculation flow proportionality factor" description="proportionality factor linking fluid recirculation flow to lymph flow via small pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.96">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="27" />
+                  </Parameter>
+                  <Parameter id="foCu5cPw4UaOWOvnMFgb3g" name="Lymph flow proportionality factor" description="Proportionality factor linking lymph flow to plasma flow" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.00204">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="58" />
+                  </Parameter>
+                  <Parameter id="AWMBH3MgN0iO1ZE-Rt_Tfg" name="Organ volume mouse" description="Organ volume mouse" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.00011" displayUnit="l">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="65" />
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+                    <Info min="0.75" max="0.75" flag="54" seq="1" ref="0" bb="32" group="2" />
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+                      <Tag value="TissueOrgan" />
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+                    <Info min="0" max="1" flag="54" seq="1" ref="0" bb="32" group="94" />
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+                  <Parameter id="eDfZnFS9x0yfAeTTx3fViQ" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.05">
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+                      <Tag value="Portal Vein Supplying Organ" />
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+                    <Info min="0" max="1" flag="122" seq="14" ref="0" bb="32" group="114" />
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+                  <Parameter id="Zl9SuurDH0mK0UU2tImdJw" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" icon="Parameter" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="3.97222222222222E-11" displayUnit="ml/min/N">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
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+                    <Info min="0" flag="122" seq="14" ref="0" bb="32" group="115" />
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+                    <Info min="0" flag="122" seq="14" ref="0" bb="32" group="55" />
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+                  <Parameter id="Rfmf-RNTv0WlvaBQ0XwOTw" name="Radius (small pores)" description="Small endothelial pores radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="4.5E-08" displayUnit="µm">
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+                    <Info min="0" flag="122" seq="14" ref="0" bb="32" group="99" />
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+                  <Parameter id="Dq66d0L2Y02kyLM2WvATJw" name="Fraction vascular" description="Fraction of vascular space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.032">
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+                      <Tag value="Portal Vein Supplying Organ" />
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+                    <Info min="0" max="1" flag="62" seq="42" ref="0" bb="32" group="64" />
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+                    <Info min="0" max="1" flag="122" seq="43" ref="0" bb="32" group="86" />
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+                  <Parameter id="lJ48eySDVESavkj4LBWfew" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.133">
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+                    <Info min="0" max="1" flag="122" seq="43" ref="0" bb="32" group="85" />
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+                  <Parameter id="X7qY1y5IUE-XCXv7gpbNRA" name="Fraction interstitial" description="Fraction of interstitial space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.1">
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+                    <Info min="0" max="1" flag="62" seq="44" ref="0" bb="32" group="64" />
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+                  <Parameter id="ubcaU1wO5kyQqNixh3pBSw" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.158">
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+                    <Info min="0" max="1" flag="122" seq="44" ref="0" bb="32" group="111" />
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+                    <Info min="0" max="1" flag="122" seq="44" ref="0" bb="32" group="112" />
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+                    <Info min="0" max="1" flag="122" seq="44" ref="0" bb="32" group="86" />
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+                    <Info min="0" max="1" flag="122" seq="72" ref="0" bb="32" group="92" />
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+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="65" />
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+                        <Info min="0" flag="34" seq="1" ref="0" bb="32" group="65" />
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+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="65" />
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+                      <Container id="BTIcwg_CJk2-gGT8IgcAKA" name="Aciclovir" mode="Logical" containerType="Molecule" />
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+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="5" />
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+                        <Info min="0" flag="50" seq="1" ref="0" bb="32" group="5" />
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+                      <Parameter id="Ez1VWMeukk-p242OyOVNhA" name="Deviation" description="Standard deviation of Normal distribution" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.019305" displayUnit="ml/min/100g organ">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="5" />
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+                    <Tags>
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+                      <Tag value="Stomach" />
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+                      <Parameter id="1aArJ44zkUe0955E13DtdA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="WiDWMA7xi02WdVvl1Rjr0g" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
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+                      <Observer id="ATNwUdA8TUiH8dK2cZ-kTg" name="Interstitial Unbound" description="Interstitial Unbound" icon="Observer" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" negativeValuesAllowed="1" formula="9puGFowK4EWaB_uKiCUkZg" displayUnit="µmol/l" />
+                      <Observer id="7Au_SEUleEOARhbjFfzI4w" name="Intracellular Unbound" description="Intracellular Unbound" icon="Observer" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" negativeValuesAllowed="1" formula="teOQNDXPokGxR8_kXybQ_A" displayUnit="µmol/l" />
+                      <Observer id="2RuRmbnFqUOUzCyjpNJ37w" name="Tissue" description="Tissue" icon="Observer" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" negativeValuesAllowed="1" formula="vXvnx5OPgEOFlJ6Oq1kSGw" displayUnit="µmol/l" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Container>
+              <Container id="AH5hcQXaMkCO0dxwzTvySA" name="SmallIntestine" description="SmallIntestine" icon="SmallIntestine" mode="Logical" containerType="Organ">
+                <Tags>
+                  <Tag value="Portal Vein Supplying Organ" />
+                  <Tag value="TissueOrgan" />
+                </Tags>
+                <Children>
+                  <Parameter id="3MlVSGE0YUKq1uxzAfv87A" name="Small intestinal transit time factor" description="Small intestinal transit time factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="31_U_Plc9UO5VkKK7QWGJw" isDefault="1">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="38" seq="1" ref="0" bb="32" group="46" />
+                  </Parameter>
+                  <Parameter id="kja0BIedz0iUM5194M5Ziw" name="Weight (tissue)" description="Weight of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="fliUWazsPUiRy_qjzM6EaA" isDefault="1" displayUnit="kg">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
+                  </Parameter>
+                  <Parameter id="0ATqcD4pZ0mWVbNprdNdcQ" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="XfFmtsJCVECrewEFcmePfg" isDefault="1" displayUnit="l/min">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
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+                    <Info min="0" flag="62" seq="15" ref="0" bb="32" group="27" />
+                  </Parameter>
+                  <Parameter id="YVsQ4MhcdEuyNslzEhKkvQ" name="Fluid recirculation flow rate (incl. mucosa)" description="Fluid recirculation flow rate between plasma and interstitial space (incl. mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="SEONXx9l8UekWRlG-vCS6A" isDefault="1" displayUnit="l/min">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
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+                    <Info min="0" flag="122" seq="15" ref="0" bb="32" group="27" />
+                  </Parameter>
+                  <Parameter id="erX7ArSo5UG4vU3izwKpBQ" name="Lymph flow rate" description="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="bQbopld300iirdAMAMFiqQ" isDefault="1" displayUnit="l/min">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
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+                    <Info min="0" flag="62" seq="15" ref="0" bb="32" group="58" />
+                  </Parameter>
+                  <Parameter id="O8fIRMMAPEqM222ZDJAmSA" name="Lymph flow rate (incl. mucosa)" description="Lymph flow rate (incl. mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="AHUOFh7VvEGdn9pbFbN0Ng" isDefault="1" displayUnit="l/min">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
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+                    <Info min="0" flag="122" seq="15" ref="0" bb="32" group="58" />
+                  </Parameter>
+                  <Parameter id="aNm06gRC40u_mooxsKLR4g" name="Volume (endothelium)" description="Volume of  vascular endothelium" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="2FCIaKEsn0G1CVh6XTgvmA" isDefault="1" displayUnit="l">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="62" seq="15" ref="0" bb="32" group="127" />
+                  </Parameter>
+                  <Parameter id="vP0ztCwUjkOzaqIC8Jf6FA" name="Fraction intracellular" description="Fraction of intracellular space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="I-HZynBcWEaZVIcFkF3iMQ" isDefault="1">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="62" seq="46" ref="0" bb="32" group="64" />
+                  </Parameter>
+                  <Parameter id="90jMuiDbJ0CiihluqmMGfw" name="Blood flow rate" description="Organ blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="y6LwIbRu9ku8erXKf1RN9w" isDefault="1" displayUnit="l/min">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="48" source="Other" description="Absolute value = specific value (i.e. value normalized to the volume of the organ) multiplied by the organ volume" />
+                    <Info min="0" flag="62" seq="222" ref="0" bb="32" group="5" />
+                  </Parameter>
+                  <Parameter id="d5l5_QzSxEqIcPpb2Drshg" name="Volume (mucosa)" description="Volume of mucosa" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="fWHDGqYaqE62TgJM_WfFmw" isDefault="1" displayUnit="l">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="62" seq="666" ref="0" bb="32" group="129" />
+                  </Parameter>
+                  <Parameter id="WkHggJk5IUW8hfPYzO44vQ" name="Density (tissue)" description="Density of tissue" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="38" seq="1" ref="0" bb="32" group="21" />
+                  </Parameter>
+                  <Parameter id="ZL7rEa9PAESuzUr8sRQFDQ" name="Fluid recirculation flow proportionality factor" description="proportionality factor linking fluid recirculation flow to lymph flow via small pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.179">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="27" />
+                  </Parameter>
+                  <Parameter id="mbM4f3vlq0qtkkZwTnw9bw" name="Lymph flow proportionality factor" description="Proportionality factor linking lymph flow to plasma flow" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.00195">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="58" />
+                  </Parameter>
+                  <Parameter id="WWBSpnbNV0mx_hyEbkT_NQ" name="Organ volume mouse" description="Organ volume mouse" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.001406" displayUnit="l">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="65" />
+                  </Parameter>
+                  <Parameter id="mDnSum7oGUaYkEj0NkG2Mw" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.75">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0.75" max="0.75" flag="54" seq="1" ref="0" bb="32" group="2" />
+                  </Parameter>
+                  <Parameter id="apTMMu0FGUOwhTqRgMBJ9Q" name="Mucosa blood flow fraction" description="Blood fraction which goes to mucosa" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.75">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="39" />
+                  </Parameter>
+                  <Parameter id="Kxf_3sqq-EOfjLe7ssvWgw" name="Small intestinal transit time factor intercept" description="Small intestinal transit time factor intercept" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="-4.52">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info flag="52" seq="1" ref="0" bb="32" group="46" />
+                  </Parameter>
+                  <Parameter id="JT7ZiMD0j06NbxCBuEH0Ng" name="Small intestinal transit time factor slope" description="Small intestinal transit time factor slope" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.602" displayUnit="1/min">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info flag="52" seq="1" ref="0" bb="32" group="46" />
+                  </Parameter>
+                  <Parameter id="DNGejMvQc02by0wEm-6ouA" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="54" seq="1" ref="0" bb="32" group="94" />
+                  </Parameter>
+                  <Parameter id="iaw_Wn_8UE-xpwJUxG0SUg" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.05">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
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+                    <Info min="0" max="1" flag="122" seq="15" ref="0" bb="32" group="114" />
+                  </Parameter>
+                  <Parameter id="YGfvuqGVr06JJ6VId5xBkw" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" icon="Parameter" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.53888888888889E-10" displayUnit="ml/min/N">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
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+                    <Info min="0" flag="122" seq="15" ref="0" bb="32" group="115" />
+                  </Parameter>
+                  <Parameter id="UOuiMBtGekiobXUM72WrPQ" name="Radius (large pores)" description="Large endothelial pores radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.5E-07" displayUnit="µm">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
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+                    <Info min="0" flag="122" seq="15" ref="0" bb="32" group="55" />
+                  </Parameter>
+                  <Parameter id="PkMEo2bJI0eAaouJu1QpXA" name="Radius (small pores)" description="Small endothelial pores radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="4.5E-08" displayUnit="µm">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
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+                    <Info min="0" flag="122" seq="15" ref="0" bb="32" group="99" />
+                  </Parameter>
+                  <Parameter id="1KIgqVroukWVnJyIHnAggg" name="Fraction vascular" description="Fraction of vascular space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.024">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="19" source="Publication" description="Kawai R, Lemaire M, Steimer JL, Bruelisauer A, Niederberger W, Rowland M. Physiologically based pharmacokinetic study on a cyclosporin derivative, SDZ IMM 125. J Pharmacokinet Biopharm. 1994 Oct;22(5):327-65." />
+                    <Info min="0" max="1" flag="62" seq="45" ref="0" bb="32" group="64" />
+                  </Parameter>
+                  <Parameter id="sF2TbvAeYEycSO51HxDKyw" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.062">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
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+                    <Info min="0" max="1" flag="122" seq="45" ref="0" bb="32" group="85" />
+                  </Parameter>
+                  <Parameter id="7yjNm-ZIvEq8j00Er-DARA" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0487">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
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+                    <Info min="0" max="1" flag="122" seq="45" ref="0" bb="32" group="86" />
+                  </Parameter>
+                  <Parameter id="9hLwnrkapEWQE6n8PzgVzw" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0163">
+                    <Tags>
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+                    <Info min="0" max="1" flag="122" seq="46" ref="0" bb="32" group="86" />
+                  </Parameter>
+                  <Parameter id="iQc4fU1xkUa2ERK2hf1g-g" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.133">
+                    <Tags>
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+                    <Info min="0" max="1" flag="122" seq="46" ref="0" bb="32" group="85" />
+                  </Parameter>
+                  <Parameter id="J0u55GmjMEWz7S5KDtMSEQ" name="Fraction interstitial" description="Fraction of interstitial space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.094">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
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+                    <Info min="0" max="1" flag="62" seq="47" ref="0" bb="32" group="64" />
+                  </Parameter>
+                  <Parameter id="tQLxR9N45UqTIsQGO2qrtQ" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.158">
+                    <Tags>
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+                    <Info min="0" max="1" flag="122" seq="47" ref="0" bb="32" group="111" />
+                  </Parameter>
+                  <Parameter id="Pv5wgBZmdEKjiDrCfVSIsQ" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                    <Tags>
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+                    <ValueOrigin id="24" source="Publication" description="POULIN P, THEIL F. Prediction of Pharmacokinetics Prior to In Vivo Studies. 1. Mechanism-Based Prediction of Volume of Distribution. JOURNAL OF PHARMACEUTICAL SCIENCES, VOL. 91, NO. 1, JANUARY 2002" />
+                    <Info min="0" max="1" flag="122" seq="47" ref="0" bb="32" group="112" />
+                  </Parameter>
+                  <Parameter id="QhM-o6nLl0uF3ilEma94Qg" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.141">
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+                    <Info min="0" max="1" flag="122" seq="47" ref="0" bb="32" group="113" />
+                  </Parameter>
+                  <Parameter id="J7jBAyWXRkqILMa2pLDb8Q" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.792">
+                    <Tags>
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+                    <Info min="0" max="1" flag="122" seq="47" ref="0" bb="32" group="85" />
+                  </Parameter>
+                  <Parameter id="qpmLwpPru0y9iu8QOgfvIg" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.718">
+                    <Tags>
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+                    <Info min="0" max="1" flag="122" seq="47" ref="0" bb="32" group="86" />
+                  </Parameter>
+                  <Parameter id="ftjvn5CiikehtNNknpbcsw" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0375">
+                    <Tags>
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+                    </Tags>
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+                    <Info min="0" max="1" flag="122" seq="75" ref="0" bb="32" group="92" />
+                  </Parameter>
+                  <Parameter id="4_mdKUTFT0eTSV6C2QVhQA" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0483">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="75" ref="0" bb="32" group="95" />
+                  </Parameter>
+                  <Parameter id="N6KIGQ6FfkelIgfHg0MAjQ" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0124">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="22" source="Publication" description="Rodgers T, Rowland M. Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J Pharm Sci. 2006 Jun;95(6):1238-57 https://doi.org/10.1002/jps.20502" />
+                    <Info min="0" max="1" flag="122" seq="76" ref="0" bb="32" group="92" />
+                  </Parameter>
+                  <Parameter id="MOqcrH_vkUKwZMzKjzb9nQ" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0182">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="76" ref="0" bb="32" group="95" />
+                  </Parameter>
+                  <Parameter id="8bc8jPamoE-FYPPvwZh5Jw" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.282">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
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+                    </Tags>
+                    <ValueOrigin id="21" source="Publication" description="Rodgers T, Leahy D, Rowland M. Physiologically based pharmacokinetic modeling 1: predicting the tissue distribution of moderate-to-strong bases. J Pharm Sci. 2005 Jun;94(6):1259-76. https://doi.org/10.1002/jps.20322" />
+                    <Info min="0" max="1" flag="122" seq="77" ref="0" bb="32" group="92" />
+                  </Parameter>
+                  <Parameter id="V9MkW7pueUW-8sOmGsbP6A" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.15">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="77" ref="0" bb="32" group="95" />
+                  </Parameter>
+                  <Parameter id="_nMpQDqrnkuyxGy54CI8RA" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.456">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="22" source="Publication" description="Rodgers T, Rowland M. Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J Pharm Sci. 2006 Jun;95(6):1238-57 https://doi.org/10.1002/jps.20502" />
+                    <Info min="0" max="1" flag="122" seq="78" ref="0" bb="32" group="92" />
+                  </Parameter>
+                  <Parameter id="6VQ_weDpM0umsaTo0cPRLQ" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.78">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="78" ref="0" bb="32" group="95" />
+                  </Parameter>
+                  <Parameter id="4en_ejnc3EuWfW4BKArTHQ" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.41">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
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+                    <Info min="0" max="1000" flag="122" seq="79" ref="0" bb="32" group="92" />
+                  </Parameter>
+                  <Parameter id="2GDKXh6_LESTewpFxHK0QQ" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0035">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="79" ref="0" bb="32" group="95" />
+                  </Parameter>
+                  <DistributedParameter id="Mq6bUbRBT0CfelKgw94j6g" name="Small intestinal transit time" description="The time required for the passage of a non-absorbable compound through the small intestine, defined as the time span between gastric emptying (i.e. the point at which 63% of the drug mass has entered the duodenum) and the time at which 90% has entered the caecum" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="2FNY3ByZiUefMO_U4bkZJQ" mode="Logical" isDefault="1" displayUnit="h">
+                    <Children>
+                      <Parameter id="xJaS3bCwfEK8GQGTbRh9ZQ" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="46" />
+                      </Parameter>
+                      <Parameter id="vwjRkkBbXk-SyhO7uHqlRQ" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="126" displayUnit="h">
+                        <Info min="27.2" max="1200" flag="50" seq="1" ref="0" bb="32" group="46" />
+                      </Parameter>
+                      <Parameter id="eVMlat7EaEaaCU50FmtT4Q" name="GeometricDeviation" description="Geometric standard deviation of LogNormal distribution" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.6">
+                        <Info min="1" flag="18" seq="1" ref="0" bb="32" group="46" />
+                      </Parameter>
+                      <Container id="V3CDBhztmEe7jHtsCiRVtw" name="Aciclovir" mode="Logical" containerType="Molecule" />
+                    </Children>
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="27.2" max="1200" flag="122" seq="1" ref="0" bb="32" group="46" />
+                  </DistributedParameter>
+                  <DistributedParameter id="JXcRMJwkBEynvRQwRnQFMg" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="q5RmzuBHQUOPpv6fL2JhbQ" mode="Logical" isDefault="1" displayUnit="l">
+                    <Children>
+                      <Parameter id="6tyIbj4G50K5lJEC_oBosQ" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.502004214302767">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="65" />
+                      </Parameter>
+                      <Parameter id="J8G-4J_f3U2G1lZrJCd6Gw" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.7240974816" displayUnit="l">
+                        <Info min="0" flag="34" seq="1" ref="0" bb="32" group="65" />
+                      </Parameter>
+                      <Parameter id="5znESHirzEm50uSKEZlwdg" name="Deviation" description="Standard deviation of Normal distribution" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.084725566517592" displayUnit="l">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="65" />
+                      </Parameter>
+                      <Container id="YmffjJjn8kK46DAMpn38BA" name="Aciclovir" mode="Logical" containerType="Molecule" />
+                    </Children>
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
+                    <Info min="0" flag="106" seq="16" ref="0" bb="32" group="65" />
+                  </DistributedParameter>
+                  <DistributedParameter id="sh0IfEgYxEKXpI901uVk9A" name="Specific blood flow rate" description="Blood flow rate normalized to the organ volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" formula="W-gc3i6Vv0mU5vjJoQSwQg" mode="Logical" isDefault="1" displayUnit="ml/min/100g organ">
+                    <Children>
+                      <Parameter id="eW8yD_iCtU6S5QjxwxF-Uw" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="5" />
+                      </Parameter>
+                      <Parameter id="X6flUEJtu0eV-1wYxPx5Tw" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.89765" displayUnit="ml/min/100g organ">
+                        <Info min="0" flag="50" seq="1" ref="0" bb="32" group="5" />
+                      </Parameter>
+                      <Parameter id="pEyDW58IMkS2q1oWAhqPvA" name="Deviation" description="Standard deviation of Normal distribution" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0448825" displayUnit="ml/min/100g organ">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="5" />
+                      </Parameter>
+                      <Container id="zQYZP5QujUeUeuaU9QiEMA" name="Aciclovir" mode="Logical" containerType="Molecule" />
+                    </Children>
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="40" source="Publication" description="Edginton, A.N., Schmitt, W. &amp; Willmann, S. Clin Pharmacokinet (2006) 45: 1013. https://doi.org/10.2165/00003088-200645100-00005" />
+                    <Info min="0" flag="122" seq="221" ref="0" bb="32" group="5" />
+                  </DistributedParameter>
+                  <Container id="Fy6Itf9MIUGQAeAvyt7KGg" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="SmallIntestine" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="D5VaqgWUwk6wSHxa3CgxTQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="WiDWMA7xi02WdVvl1Rjr0g" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="HoBOe46xv0uhfM7nxXovwg" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="iKmS3ppFAU-9Z6ITythjAg" isDefault="1" displayUnit="l">
+                        <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
+                        <Info min="0" flag="62" seq="15" ref="0" bb="2" group="126" />
+                      </Parameter>
+                      <MoleculeAmount id="KwZlGLX-DECXQoxDdqMTCw" name="CYP344" icon="ENZYME" persistable="0" isFixedValue="0" dim="Amount" quantityType="Enzyme" negativeValuesAllowed="0" formula="rMXLZglcaUaofPZ0c6I6Yw" mode="Logical" scaleDivisor="1" displayUnit="µmol">
+                        <Children>
+                          <Parameter id="Y_qBXGvMXUKrdd8vgPnKSg" name="Degradation coefficient" description="First order turnover rate constant of the enzyme" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="c2fNMePAyki4XPdR-AEHaQ" isDefault="1" displayUnit="1/min">
+                            <ValueOrigin id="33" source="Other" description="OSP Suite Manual Chapter 16. PK-Sim®- Compounds: Defining inhibition/induction processes" />
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="9DE3MRH9P0CzAIBe-IV-Yw" name="Relative expression" description="Relative expression" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="fqrxyq94VkWMTLJeRjjhEQ" isDefault="1">
+                            <Info min="0" flag="60" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="4WS3Lu4RakGWajiw5hNVbA" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="YQ_SIzoIak2o9B3xCbLazA" isDefault="1">
+                            <Info min="0" flag="58" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="CGhQpyOdc0mj79lH1bgUCg" name="Relative expression out." description="Relative Expression that will be used in the simulation" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="fbRCNZOks0i0JlaOaYnbvg" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="yCJHMaG_TU-52jfp74UL5Q" name="Start amount" description="Start amount of molecule" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" formula="EPX-QNxBZE2pcwiBNY6NfA" isDefault="1" displayUnit="µmol">
+                            <Info flag="54" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="zc26o_MVa0SZhpCC5XlwMg" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="_5AQF4X5mkuTWnIB24ghvw" isDefault="1" displayUnit="µmol/l">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Parameter id="skOpzDCZLEy2xWL4jtTG-Q" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="zzLL4LrjR0qwZbDT_r2hFQ" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                          </Parameter>
+                          <Parameter id="oboBlBL9bk2AS4dUCs-xJw" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="pivOUE13XUqSSttBz2LA2g" isDefault="1" displayUnit="min">
+                            <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Observer id="Sd0N1a9eq0yrq1xHaPL3Dg" name="Concentration in container" description="Concentration of the molecule" icon="Observer" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Enzyme, Observer" negativeValuesAllowed="1" formula="6wCmGaSt3UirOnRpXv6unA" displayUnit="µmol/l" />
+                        </Children>
+                      </MoleculeAmount>
+                      <MoleculeAmount id="WaDZEuqgsEyV_ckNljlU_g" name="Aciclovir" icon="DRUG" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" negativeValuesAllowed="0" mode="Logical" scaleDivisor="1" value="0" displayUnit="µmol">
+                        <Children>
+                          <Parameter id="iomkGxvNIE2fdaElAKOOZw" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="_5AQF4X5mkuTWnIB24ghvw" isDefault="1" displayUnit="µmol/l">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Parameter id="MPFx8UO42EGVYS1DDx7PYw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="0AWHzn6fx0qH_k6MkXTBDw" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                          </Parameter>
+                          <Observer id="FgqA0sSo6UiQ3B77tiuqQg" name="Concentration in container" description="Concentration of the molecule" icon="Observer" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" negativeValuesAllowed="1" formula="6wCmGaSt3UirOnRpXv6unA" displayUnit="µmol/l" />
+                        </Children>
+                      </MoleculeAmount>
+                    </Children>
+                  </Container>
+                  <Container id="Tg8zUU7tQUiyXi7TzpD9tA" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="SmallIntestine" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="pYceThI6_Em9V4iChGWoqQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="WiDWMA7xi02WdVvl1Rjr0g" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
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+                      <Parameter id="k0vEHX71ykCRhx9JHyMuvw" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="Mg3W60_RhEm_v4eTI1SOOg" isDefault="1" displayUnit="l">
+                        <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
+                        <Info min="0" flag="62" seq="15" ref="0" bb="2" group="121" />
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+                      <MoleculeAmount id="giQHUSajTUmRnEyEG2aE0g" name="CYP344" icon="ENZYME" persistable="0" isFixedValue="0" dim="Amount" quantityType="Enzyme" negativeValuesAllowed="0" formula="rMXLZglcaUaofPZ0c6I6Yw" mode="Logical" scaleDivisor="1" displayUnit="µmol">
+                        <Children>
+                          <Parameter id="BKJ1tiVAFkiGLJRuo9W9jg" name="Degradation coefficient" description="First order turnover rate constant of the enzyme" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="c2fNMePAyki4XPdR-AEHaQ" isDefault="1" displayUnit="1/min">
+                            <ValueOrigin id="33" source="Other" description="OSP Suite Manual Chapter 16. PK-Sim®- Compounds: Defining inhibition/induction processes" />
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="91" />
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+                          <Parameter id="UBt2MLDr00Gyj-xeSpVenA" name="Relative expression" description="Relative expression" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="cLw6IJb0kk-aHdh1YkXHkw" isDefault="1">
+                            <Info min="0" flag="60" seq="1" ref="0" bb="2" group="91" />
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+                          <Parameter id="0Yu2FUghCE-IK5Ox2TAiYA" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="xTktpLRZC0e7-rlZenlyLg" isDefault="1">
+                            <Info min="0" flag="58" seq="1" ref="0" bb="2" group="91" />
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+                          <Parameter id="AztZ5B5KQEebIwRP1KC7cQ" name="Relative expression out." description="Relative Expression that will be used in the simulation" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="fbRCNZOks0i0JlaOaYnbvg" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="91" />
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+                          <Parameter id="X7t6yLqHjkiQib8avpjplQ" name="Start amount" description="Start amount of molecule" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" formula="EPX-QNxBZE2pcwiBNY6NfA" isDefault="1" displayUnit="µmol">
+                            <Info flag="54" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="_mXvyOGZrUqxyLMIZknCzA" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="_5AQF4X5mkuTWnIB24ghvw" isDefault="1" displayUnit="µmol/l">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Parameter id="MlbjIi-6Y06YgrtkhSEQ8g" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="otuin385g0-l770rgIRklg" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
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+                          <Parameter id="s9WX99vbOk6Bybuh_h2CRQ" name="Fraction interstitial" description="Fraction of interstitial space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.42">
+                            <Info min="0" max="1" flag="62" seq="335" ref="0" bb="32" group="64" />
+                          </Parameter>
+                          <Parameter id="lSV_9TqMKUmNKSYh01vILQ" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.158">
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+                            <Info min="0" max="1" flag="122" seq="557" ref="0" bb="32" group="92" />
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+                              <Tag value="SmallIntestineSegment" />
+                            </Tags>
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+                                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
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+                              <Tag value="SmallIntestineSegment" />
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+                            </Tags>
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+                        </Children>
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+                        <Children>
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+                            <Info min="0" max="1" flag="122" seq="339" ref="0" bb="32" group="85" />
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+                              <Parameter id="vnEL1bLb7Uio6dAPdH7TZw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="J_zsXA_hVEGtRM46zqPvJg" isDefault="1" displayUnit="l">
+                                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                              </Parameter>
+                              <Parameter id="Z46EJ8qj0k6qj66_Ketzww" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="GXZJgB5-lEOADgF16J9WjQ" isDefault="1" displayUnit="l">
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+                                <Info min="0" flag="62" seq="113" ref="0" bb="2" group="125" />
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+                              <Parameter id="VYWLAaL_YUmLF7rAkMxH-Q" name="pH" description="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.3">
+                                <Tags>
+                                  <Tag value="IntestinalSecretionSource" />
+                                  <Tag value="LowerJejunum" />
+                                  <Tag value="Mucosa" />
+                                  <Tag value="SmallIntestineSegment" />
+                                </Tags>
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+                                <Info min="0" max="14" flag="122" seq="341" ref="0" bb="32" group="83" />
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+                              <MoleculeAmount id="HNjlX6EU70G5K4R60ES6Ew" name="CYP344" icon="ENZYME" persistable="0" isFixedValue="0" dim="Amount" quantityType="Enzyme" negativeValuesAllowed="0" formula="rMXLZglcaUaofPZ0c6I6Yw" mode="Logical" scaleDivisor="1" displayUnit="µmol">
+                                <Children>
+                                  <Parameter id="bBTdErUuQkqXrhwjzETI4w" name="Degradation coefficient" description="First order turnover rate constant of the enzyme" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="c2fNMePAyki4XPdR-AEHaQ" isDefault="1" displayUnit="1/min">
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+                                  <Parameter id="qLrZ-qRgBEWCVReWvVVKHg" name="Relative expression" description="Relative expression" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0">
+                                    <Info min="0" flag="60" seq="1" ref="0" bb="32" group="91" />
+                                  </Parameter>
+                                  <Parameter id="anGkrVygOEmiuXoVpLiB_A" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0">
+                                    <Info min="0" flag="58" seq="1" ref="0" bb="32" group="91" />
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+                                  <Parameter id="xh-ponbIgkeimSxVBfGdgA" name="Relative expression out." description="Relative Expression that will be used in the simulation" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="fbRCNZOks0i0JlaOaYnbvg" isDefault="1">
+                                    <Info min="0" flag="52" seq="1" ref="0" bb="2" group="91" />
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+                                  <Parameter id="GiB-9xB2LEWYV6NQwXpEog" name="Start amount" description="Start amount of molecule" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" formula="EPX-QNxBZE2pcwiBNY6NfA" isDefault="1" displayUnit="µmol">
+                                    <Info flag="54" seq="1" ref="0" bb="2" group="91" />
+                                  </Parameter>
+                                  <Parameter id="I3_VxCp_P0GfSmPHGcdINg" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="_5AQF4X5mkuTWnIB24ghvw" isDefault="1" displayUnit="µmol/l">
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+                                    <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                                  </Parameter>
+                                  <Parameter id="mox9WSiLcU6IyQMaSB2duQ" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="HiXgbg3RAEaWyCDbpP72bw" isDefault="1" displayUnit="min">
+                                    <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                                  </Parameter>
+                                  <Observer id="uivScMpHTkSSElqDbgeTwQ" name="Concentration in container" description="Concentration of the molecule" icon="Observer" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Enzyme, Observer" negativeValuesAllowed="1" formula="6wCmGaSt3UirOnRpXv6unA" displayUnit="µmol/l" />
+                                </Children>
+                              </MoleculeAmount>
+                              <MoleculeAmount id="X63NpTl_LEiYK284w5QvOQ" name="Aciclovir" icon="DRUG" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" negativeValuesAllowed="0" mode="Logical" scaleDivisor="1" value="0" displayUnit="µmol">
+                                <Children>
+                                  <Parameter id="5ID0ULF-k0uDgFEGXldHsQ" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="_5AQF4X5mkuTWnIB24ghvw" isDefault="1" displayUnit="µmol/l">
+                                    <Info min="0" flag="18" seq="1" ref="0" bb="2" group="117" />
+                                  </Parameter>
+                                  <Parameter id="8sigfgA4kk6SGaxL6G2kAg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Oo9vViWKz06_pbn12XwSOQ" isDefault="1">
+                                    <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                                  </Parameter>
+                                  <Observer id="RfVRouhnQ0yDjI971fgcKw" name="Concentration in container" description="Concentration of the molecule" icon="Observer" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" negativeValuesAllowed="1" formula="6wCmGaSt3UirOnRpXv6unA" displayUnit="µmol/l" />
+                                </Children>
+                              </MoleculeAmount>
+                            </Children>
+                          </Container>
+                        </Children>
+                      </Container>
+                      <Container id="uujBOVOytkGoRd5oSDEYpw" name="UpperIleum" description="Upper Ileum" icon="UpperIleum" mode="Logical" containerType="Compartment">
+                        <Children>
+                          <Parameter id="rUnlWa7Iqkiw9ddOER3Rag" name="Weight (tissue)" description="Weight of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="fliUWazsPUiRy_qjzM6EaA" isDefault="1" displayUnit="kg">
+                            <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
+                          </Parameter>
+                          <Parameter id="xaSbqCyy_kGDx-f7mptfHQ" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="Ja4zTNJbFUao5F5OyUxp6w" isDefault="1" displayUnit="l">
+                            <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
+                            <Info min="0" flag="122" seq="23" ref="0" bb="32" group="65" />
+                          </Parameter>
+                          <Parameter id="GSpEJ5JXMUCqoFDINhf7wQ" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="QlYSvoeuX02TuHXPVFZCtA" isDefault="1" displayUnit="l/min">
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+                          <Parameter id="3nFuVSaH-0C3ZosFsyML_g" name="Lymph flow rate" description="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="d1cVNZytnE2lcqXnxo351w" isDefault="1" displayUnit="l/min">
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+                          </Parameter>
+                          <Parameter id="ekriTQV9X0i_LdGrkVHi-g" name="Volume (endothelium)" description="Volume of  vascular endothelium" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="ygIEcrMluEGuwtmn0dJ3wA" isDefault="1" displayUnit="l">
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+                          <Parameter id="YRgrJkE6ok-vc45OuHmlIg" name="Blood flow rate" description="Organ blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="zgx06UYiLE-TFvmfLI4jxA" isDefault="1" displayUnit="l/min">
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+                          <Parameter id="ifNXN4dEOUmuFPzqpH-_uA" name="Fraction intracellular" description="Fraction of intracellular space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="I-HZynBcWEaZVIcFkF3iMQ" isDefault="1">
+                            <Info min="0" max="1" flag="62" seq="343" ref="0" bb="32" group="64" />
+                          </Parameter>
+                          <Parameter id="JmbDnV0yPE6-Rt_-MYECxQ" name="Density (tissue)" description="Density of tissue" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
+                            <Info min="0" flag="38" seq="1" ref="0" bb="32" group="21" />
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+                          <Parameter id="TEfkSpWTyE6EyFWHiQT-Bg" name="Fraction mucosa" description="Mucosal fraction of regional intestinal tissue mass" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.13">
+                            <Info min="0" max="1" flag="122" seq="1" ref="0" bb="32" group="40" />
+                          </Parameter>
+                          <Parameter id="R3f4_Iqk5E2BpA0lOf_L5A" name="Fraction of regional blood flow rate" description="Regional blood flow fraction supplying the mucosal tissue of the segment" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.2345">
+                            <Info min="0" flag="54" seq="1" ref="0" bb="32" group="39" />
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+                          <Parameter id="c11RhjB9t0mgXgnOLvtuDg" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                            <Info min="0" max="1" flag="54" seq="1" ref="0" bb="32" group="94" />
+                          </Parameter>
+                          <Parameter id="U5xaYtHM30Onlx15qm1LCQ" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.05">
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+                            <Info min="0" max="1" flag="122" seq="114" ref="0" bb="32" group="114" />
+                          </Parameter>
+                          <Parameter id="sY170vRMW0WzeQCX7o-aFg" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" icon="Parameter" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.53888888888889E-10" displayUnit="ml/min/N">
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+                          <Parameter id="iyRPbQDw5EOgDYNaVw3R6Q" name="Radius (large pores)" description="Large endothelial pores radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.5E-07" displayUnit="µm">
+                            <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
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+                            <Info min="0" flag="122" seq="114" ref="0" bb="32" group="99" />
+                          </Parameter>
+                          <Parameter id="rOMbP1pDhEK0l-mcJhHmcg" name="Fraction vascular" description="Fraction of vascular space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.13">
+                            <Info min="0" max="1" flag="62" seq="342" ref="0" bb="32" group="64" />
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+                          <Parameter id="yvHF_m1pGkmcvD_Iu3UTMQ" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.06">
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+                            <Info min="0" max="1" flag="122" seq="342" ref="0" bb="32" group="85" />
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+                            <Info min="0" max="1" flag="122" seq="342" ref="0" bb="32" group="86" />
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+                          <Parameter id="MoZobXNdG0mTaB8YOpQB9A" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0163">
+                            <Info min="0" max="1" flag="122" seq="343" ref="0" bb="32" group="86" />
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+                            <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
+                            <Info min="0" max="1" flag="122" seq="343" ref="0" bb="32" group="85" />
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+                          <Parameter id="2_k6Qp7-40C-MYGg_25TtA" name="Fraction interstitial" description="Fraction of interstitial space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.31">
+                            <Info min="0" max="1" flag="62" seq="344" ref="0" bb="32" group="64" />
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+                          <Parameter id="mO_IVcHscUOhiwyQOnkq-Q" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.158">
+                            <ValueOrigin id="22" source="Publication" description="Rodgers T, Rowland M. Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J Pharm Sci. 2006 Jun;95(6):1238-57 https://doi.org/10.1002/jps.20502" />
+                            <Info min="0" max="1" flag="122" seq="344" ref="0" bb="32" group="111" />
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+                            <ValueOrigin id="24" source="Publication" description="POULIN P, THEIL F. Prediction of Pharmacokinetics Prior to In Vivo Studies. 1. Mechanism-Based Prediction of Volume of Distribution. JOURNAL OF PHARMACEUTICAL SCIENCES, VOL. 91, NO. 1, JANUARY 2002" />
+                            <Info min="0" max="1" flag="122" seq="344" ref="0" bb="32" group="112" />
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+                          <Parameter id="52Mlwczm4k6ZfPnlo5HKZQ" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.141">
+                            <ValueOrigin id="22" source="Publication" description="Rodgers T, Rowland M. Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J Pharm Sci. 2006 Jun;95(6):1238-57 https://doi.org/10.1002/jps.20502" />
+                            <Info min="0" max="1" flag="122" seq="344" ref="0" bb="32" group="113" />
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+                          <Parameter id="onjUoynHiU6uKPOTEdkz1g" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.8">
+                            <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
+                            <Info min="0" max="1" flag="122" seq="344" ref="0" bb="32" group="85" />
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+                          <Parameter id="VhEkqfDD-kG5ocy0kUS2Og" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.718">
+                            <Info min="0" max="1" flag="122" seq="344" ref="0" bb="32" group="86" />
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+                          <Parameter id="BCevySKnPUGptyxTwi5nXg" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0375">
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+                            <Info min="0" max="1" flag="122" seq="570" ref="0" bb="32" group="92" />
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+                          <Parameter id="ncmx2HwsT0qJMUfqpLBWmg" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0483">
+                            <Info min="0" max="1" flag="122" seq="570" ref="0" bb="32" group="95" />
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+                          <Parameter id="emF21_Ynl0-pr-yjX4yN-g" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0124">
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+                            <Info min="0" max="1" flag="122" seq="571" ref="0" bb="32" group="92" />
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+                          <Parameter id="YbLXEmBNaEC8rMq6F5wFLQ" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0182">
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+                            <Info min="0" max="1" flag="122" seq="1" ref="0" bb="32" group="40" />
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+                            <ValueOrigin id="21" source="Publication" description="Rodgers T, Leahy D, Rowland M. Physiologically based pharmacokinetic modeling 1: predicting the tissue distribution of moderate-to-strong bases. J Pharm Sci. 2005 Jun;94(6):1259-76. https://doi.org/10.1002/jps.20322" />
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+                                  <Parameter id="U1TBfqvllkWx17lRAqoLxg" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="_5AQF4X5mkuTWnIB24ghvw" isDefault="1" displayUnit="µmol/l">
+                                    <Info min="0" flag="18" seq="1" ref="0" bb="2" group="117" />
+                                  </Parameter>
+                                  <Parameter id="TDiKb02F4UW_1a48qJex5A" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="WQil1KVpikG3tUfSwGEEsg" isDefault="1">
+                                    <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                                  </Parameter>
+                                  <Parameter id="GpVcRPEmy0W5F1NoUnkeHQ" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="r1FehzyVt0qjeTF60cJ4Rw" isDefault="1" displayUnit="min">
+                                    <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                                  </Parameter>
+                                  <Observer id="Xtf4cnYy4kml33_IOYNW9w" name="Concentration in container" description="Concentration of the molecule" icon="Observer" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Enzyme, Observer" negativeValuesAllowed="1" formula="6wCmGaSt3UirOnRpXv6unA" displayUnit="µmol/l" />
+                                </Children>
+                              </MoleculeAmount>
+                              <MoleculeAmount id="K-XpbxOHZEWVtNyPrJeVHA" name="Aciclovir" icon="DRUG" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" negativeValuesAllowed="0" mode="Logical" scaleDivisor="1" value="0" displayUnit="µmol">
+                                <Children>
+                                  <Parameter id="u1kiNAT79EaP7fOPyDmQ1w" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="_5AQF4X5mkuTWnIB24ghvw" isDefault="1" displayUnit="µmol/l">
+                                    <Info min="0" flag="18" seq="1" ref="0" bb="2" group="117" />
+                                  </Parameter>
+                                  <Parameter id="-EMFImkCrUqBNnwKjORFfw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="YVuMRszehUmA5D_ZuH20tA" isDefault="1">
+                                    <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                                  </Parameter>
+                                  <Observer id="FwjoqpzDy0SJVaccnKNtXw" name="Concentration in container" description="Concentration of the molecule" icon="Observer" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" negativeValuesAllowed="1" formula="6wCmGaSt3UirOnRpXv6unA" displayUnit="µmol/l" />
+                                </Children>
+                              </MoleculeAmount>
+                            </Children>
+                          </Container>
+                        </Children>
+                      </Container>
+                    </Children>
+                  </Container>
+                  <Container id="XbpdYGV_C0GRskNPV9b7lw" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Observer id="Lj0XSHO1XkGrIooqj8XeGA" name="Interstitial Unbound" description="Interstitial Unbound" icon="Observer" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" negativeValuesAllowed="1" formula="9puGFowK4EWaB_uKiCUkZg" displayUnit="µmol/l" />
+                      <Observer id="59jOJofzXUaTzA8HcHh92Q" name="Intracellular Unbound" description="Intracellular Unbound" icon="Observer" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" negativeValuesAllowed="1" formula="teOQNDXPokGxR8_kXybQ_A" displayUnit="µmol/l" />
+                      <Observer id="hXxBuqNU7kGgdH8P7xsTXg" name="Total Tissue (Small Intestine)" description="Mucosa and nonmucosa tissue" icon="Observer" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" negativeValuesAllowed="1" formula="jO56iZyHT02_RofbC1y20w" displayUnit="µmol/l" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Container>
+              <Container id="p-MO8jOSKEi8d6MYAVFmpw" name="LargeIntestine" description="LargeIntestine" icon="LargeIntestine" mode="Logical" containerType="Organ">
+                <Tags>
+                  <Tag value="Portal Vein Supplying Organ" />
+                  <Tag value="TissueOrgan" />
+                </Tags>
+                <Children>
+                  <Parameter id="PUcD96hL30OCr5sY8l3lKg" name="Large intestinal transit time factor" description="Large intestinal transit time factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="eZog_il4Rk2yhDTYXq3G6Q" isDefault="1">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="38" seq="1" ref="0" bb="32" group="46" />
+                  </Parameter>
+                  <Parameter id="vSsmQV_xHkGE3epUSurDCA" name="Volume (mucosa)" description="Volume of mucosa" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="edaaSeHHokuZV_ZO_Bhd9w" isDefault="1" displayUnit="l">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="62" seq="1" ref="0" bb="32" group="129" />
+                  </Parameter>
+                  <Parameter id="5JJDTZrhPUit1ITFqTUbXQ" name="Weight (tissue)" description="Weight of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="fliUWazsPUiRy_qjzM6EaA" isDefault="1" displayUnit="kg">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
+                  </Parameter>
+                  <Parameter id="v0rmLImVcESdyI465APZEQ" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="_Z62aNATUkC4XbfQy70Syw" isDefault="1" displayUnit="l/min">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="62" seq="16" ref="0" bb="32" group="27" />
+                  </Parameter>
+                  <Parameter id="TOv_fXAy3EGdn2FhLdvpug" name="Fluid recirculation flow rate (incl. mucosa)" description="Fluid recirculation flow rate between plasma and interstitial space (incl. mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="SEONXx9l8UekWRlG-vCS6A" isDefault="1" displayUnit="l/min">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="16" ref="0" bb="32" group="27" />
+                  </Parameter>
+                  <Parameter id="HUen6a53uEyqlOxgBrFU-A" name="Lymph flow rate" description="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="6n9xqY9bYEOQvP2uZnGqZw" isDefault="1" displayUnit="l/min">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="62" seq="16" ref="0" bb="32" group="58" />
+                  </Parameter>
+                  <Parameter id="zCBBLX7goEWI3Ic9ANSXLw" name="Lymph flow rate (incl. mucosa)" description="Lymph flow rate (incl. mucosa)" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="AHUOFh7VvEGdn9pbFbN0Ng" isDefault="1" displayUnit="l/min">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="16" ref="0" bb="32" group="58" />
+                  </Parameter>
+                  <Parameter id="KqZLdktifUeXIHYFRPAEZw" name="Volume (endothelium)" description="Volume of  vascular endothelium" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="uDpszY7LbUyM5aWBtxfm9g" isDefault="1" displayUnit="l">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="62" seq="16" ref="0" bb="32" group="127" />
+                  </Parameter>
+                  <Parameter id="rJ1ENkQGIkOCrLHvRe-Fwg" name="Fraction intracellular" description="Fraction of intracellular space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="I-HZynBcWEaZVIcFkF3iMQ" isDefault="1">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="62" seq="49" ref="0" bb="32" group="64" />
+                  </Parameter>
+                  <Parameter id="W0Hw8M9ws0KJZB_kyjWp-w" name="Blood flow rate" description="Organ blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="y6LwIbRu9ku8erXKf1RN9w" isDefault="1" displayUnit="l/min">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="48" source="Other" description="Absolute value = specific value (i.e. value normalized to the volume of the organ) multiplied by the organ volume" />
+                    <Info min="0" flag="62" seq="122" ref="0" bb="32" group="5" />
+                  </Parameter>
+                  <Parameter id="hwasQKxGDUejMndwXXlZzw" name="Density (tissue)" description="Density of tissue" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="38" seq="1" ref="0" bb="32" group="21" />
+                  </Parameter>
+                  <Parameter id="2s1YihkV20eTjmbe1d7V2g" name="Fluid recirculation flow proportionality factor" description="proportionality factor linking fluid recirculation flow to lymph flow via small pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.179">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="27" />
+                  </Parameter>
+                  <Parameter id="X94cdvrf90KOq_WIRbNT7Q" name="Lymph flow proportionality factor" description="Proportionality factor linking lymph flow to plasma flow" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0144">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="58" />
+                  </Parameter>
+                  <Parameter id="WtpnPTy970SqBp4J2Smsfg" name="Organ volume mouse" description="Organ volume mouse" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.000627" displayUnit="l">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="65" />
+                  </Parameter>
+                  <Parameter id="3ltMH8QESk6gtBDDhYCBwA" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.75">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0.75" max="0.75" flag="54" seq="1" ref="0" bb="32" group="2" />
+                  </Parameter>
+                  <Parameter id="jM3GhZvBsEawtGWntsar9w" name="Large intestinal transit time factor intercept" description="Large intestinal transit time factor intercept" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="47.6">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info flag="52" seq="1" ref="0" bb="32" group="46" />
+                  </Parameter>
+                  <Parameter id="YuV_TuYbkkijvVQXxnuyyA" name="Large intestinal transit time factor slope" description="Large intestinal transit time factor slope" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.938" displayUnit="1/min">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info flag="52" seq="1" ref="0" bb="32" group="46" />
+                  </Parameter>
+                  <Parameter id="uJNEwVZm1UupAPsqhGSFjg" name="Mucosa blood flow fraction" description="Blood fraction which goes to mucosa" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.75">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="39" />
+                  </Parameter>
+                  <Parameter id="Z_DaFQDtkkCjuzFRtmunGA" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="54" seq="1" ref="0" bb="32" group="94" />
+                  </Parameter>
+                  <Parameter id="otfK4v809UeQ24zHY7AstA" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.05">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" max="1" flag="122" seq="16" ref="0" bb="32" group="114" />
+                  </Parameter>
+                  <Parameter id="eA9d2Sg9vEWRWFyUGMuqNw" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" icon="Parameter" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.86944444444444E-10" displayUnit="ml/min/N">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="16" ref="0" bb="32" group="115" />
+                  </Parameter>
+                  <Parameter id="Lo4snPCkVUS_U8SSoeU9Ow" name="Radius (large pores)" description="Large endothelial pores radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.5E-07" displayUnit="µm">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="16" ref="0" bb="32" group="55" />
+                  </Parameter>
+                  <Parameter id="klCQfE2qiEqGqc5gk8snUQ" name="Radius (small pores)" description="Small endothelial pores radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="4.5E-08" displayUnit="µm">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="16" ref="0" bb="32" group="99" />
+                  </Parameter>
+                  <Parameter id="qW9GrgqgLU26Vp7CC6o38Q" name="Fraction vascular" description="Fraction of vascular space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.024">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="19" source="Publication" description="Kawai R, Lemaire M, Steimer JL, Bruelisauer A, Niederberger W, Rowland M. Physiologically based pharmacokinetic study on a cyclosporin derivative, SDZ IMM 125. J Pharmacokinet Biopharm. 1994 Oct;22(5):327-65." />
+                    <Info min="0" max="1" flag="62" seq="48" ref="0" bb="32" group="64" />
+                  </Parameter>
+                  <Parameter id="eyPH2NaE5ESm4jNg9DvjhQ" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.062">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
+                    <Info min="0" max="1" flag="122" seq="48" ref="0" bb="32" group="85" />
+                  </Parameter>
+                  <Parameter id="fKanaG--oEi4ODyjrF4RLg" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0487">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="48" ref="0" bb="32" group="86" />
+                  </Parameter>
+                  <Parameter id="XoRuTW6fM0-wZPfvOELsgQ" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0163">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="49" ref="0" bb="32" group="86" />
+                  </Parameter>
+                  <Parameter id="KMd4ca0akUa167r-QpWC9A" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.133">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
+                    <Info min="0" max="1" flag="122" seq="49" ref="0" bb="32" group="85" />
+                  </Parameter>
+                  <Parameter id="YgSvXsTPsEKREiQo5KlJeQ" name="Fraction interstitial" description="Fraction of interstitial space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.094">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="19" source="Publication" description="Kawai R, Lemaire M, Steimer JL, Bruelisauer A, Niederberger W, Rowland M. Physiologically based pharmacokinetic study on a cyclosporin derivative, SDZ IMM 125. J Pharmacokinet Biopharm. 1994 Oct;22(5):327-65." />
+                    <Info min="0" max="1" flag="62" seq="50" ref="0" bb="32" group="64" />
+                  </Parameter>
+                  <Parameter id="uzf2CQF4rE-YAuHX-HmJog" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.158">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="22" source="Publication" description="Rodgers T, Rowland M. Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J Pharm Sci. 2006 Jun;95(6):1238-57 https://doi.org/10.1002/jps.20502" />
+                    <Info min="0" max="1" flag="122" seq="50" ref="0" bb="32" group="111" />
+                  </Parameter>
+                  <Parameter id="QoC8KY2THk6WYNtOM-XdVQ" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="24" source="Publication" description="POULIN P, THEIL F. Prediction of Pharmacokinetics Prior to In Vivo Studies. 1. Mechanism-Based Prediction of Volume of Distribution. JOURNAL OF PHARMACEUTICAL SCIENCES, VOL. 91, NO. 1, JANUARY 2002" />
+                    <Info min="0" max="1" flag="122" seq="50" ref="0" bb="32" group="112" />
+                  </Parameter>
+                  <Parameter id="xY315JCdLkiZEQNV_gMkdA" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.141">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="22" source="Publication" description="Rodgers T, Rowland M. Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J Pharm Sci. 2006 Jun;95(6):1238-57 https://doi.org/10.1002/jps.20502" />
+                    <Info min="0" max="1" flag="122" seq="50" ref="0" bb="32" group="113" />
+                  </Parameter>
+                  <Parameter id="YNTslI2cmU2AXtLW7_j-iQ" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.792">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
+                    <Info min="0" max="1" flag="122" seq="50" ref="0" bb="32" group="85" />
+                  </Parameter>
+                  <Parameter id="rNwYn3dC00ecKb--AEFP9w" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.718">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="50" ref="0" bb="32" group="86" />
+                  </Parameter>
+                  <Parameter id="cZ17P1EIEUOBa-lJjTLolg" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0375">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="22" source="Publication" description="Rodgers T, Rowland M. Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J Pharm Sci. 2006 Jun;95(6):1238-57 https://doi.org/10.1002/jps.20502" />
+                    <Info min="0" max="1" flag="122" seq="80" ref="0" bb="32" group="92" />
+                  </Parameter>
+                  <Parameter id="A5hoTBo7KUSmj7q0qK7-XQ" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0483">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="80" ref="0" bb="32" group="95" />
+                  </Parameter>
+                  <Parameter id="C6bGxkAHQ067XnTX_Zkc6A" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0124">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="22" source="Publication" description="Rodgers T, Rowland M. Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J Pharm Sci. 2006 Jun;95(6):1238-57 https://doi.org/10.1002/jps.20502" />
+                    <Info min="0" max="1" flag="122" seq="81" ref="0" bb="32" group="92" />
+                  </Parameter>
+                  <Parameter id="NEmlAhchrkGjmVlPUD62UA" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0182">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="81" ref="0" bb="32" group="95" />
+                  </Parameter>
+                  <Parameter id="yrKXejxVykenbTjnj-h34Q" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.282">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="21" source="Publication" description="Rodgers T, Leahy D, Rowland M. Physiologically based pharmacokinetic modeling 1: predicting the tissue distribution of moderate-to-strong bases. J Pharm Sci. 2005 Jun;94(6):1259-76. https://doi.org/10.1002/jps.20322" />
+                    <Info min="0" max="1" flag="122" seq="82" ref="0" bb="32" group="92" />
+                  </Parameter>
+                  <Parameter id="WJmKkrTKF0uMjk7P9mQQPA" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.15">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="82" ref="0" bb="32" group="95" />
+                  </Parameter>
+                  <Parameter id="IuBFBKLeAEiz6v_7HbbYUw" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.456">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="22" source="Publication" description="Rodgers T, Rowland M. Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J Pharm Sci. 2006 Jun;95(6):1238-57 https://doi.org/10.1002/jps.20502" />
+                    <Info min="0" max="1" flag="122" seq="83" ref="0" bb="32" group="92" />
+                  </Parameter>
+                  <Parameter id="2bXMLJHSX02jDE6Loj42MA" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.78">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="83" ref="0" bb="32" group="95" />
+                  </Parameter>
+                  <Parameter id="VujmA1ItxkWB7Cw3sQclqw" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.41">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="21" source="Publication" description="Rodgers T, Leahy D, Rowland M. Physiologically based pharmacokinetic modeling 1: predicting the tissue distribution of moderate-to-strong bases. J Pharm Sci. 2005 Jun;94(6):1259-76. https://doi.org/10.1002/jps.20322" />
+                    <Info min="0" max="1000" flag="122" seq="84" ref="0" bb="32" group="92" />
+                  </Parameter>
+                  <Parameter id="-L-nDxRwCUOhoFew0b2MaA" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0035">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="84" ref="0" bb="32" group="95" />
+                  </Parameter>
+                  <DistributedParameter id="-MpVdrbVkEqNFqytelGJmg" name="Large intestinal transit time" description="The time required for the passage of a non-absorbable compound through the large intestine, defined as the time span between small intestinal transit (i.e. the point at which 90% of the drug mass has entered the caecum) and the time at which 70% is excreted into feces" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="9lDS_T8_KU-tutUAgPsDkg" mode="Logical" isDefault="1" displayUnit="h">
+                    <Children>
+                      <Parameter id="jfqdlLjbOkq5ffDvT2R5Gw" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="46" />
+                      </Parameter>
+                      <Parameter id="RUOG4kfAR0aYvYSPvxSTfA" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2652" displayUnit="h">
+                        <Info min="223" max="27000" flag="50" seq="1" ref="0" bb="32" group="46" />
+                      </Parameter>
+                      <Container id="JpLpik7sGUWrcFRPqb_m6A" name="Aciclovir" mode="Logical" containerType="Molecule" />
+                    </Children>
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="223" max="27000" flag="122" seq="1" ref="0" bb="32" group="46" />
+                  </DistributedParameter>
+                  <DistributedParameter id="CjfdImhzf0a720FZNrd9sw" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="sWx-cjF1mU-_RVbqAg0YMQ" mode="Logical" isDefault="1" displayUnit="l">
+                    <Children>
+                      <Parameter id="h-Iy7OLV1kiHBP-hQz9Rng" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.501883035372272">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="65" />
+                      </Parameter>
+                      <Parameter id="J8rop0MIsk2VzbrwE8gLfQ" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.41217159744" displayUnit="l">
+                        <Info min="0" flag="34" seq="1" ref="0" bb="32" group="65" />
+                      </Parameter>
+                      <Parameter id="OwP6VuADiEKYdJ-JWoKAxQ" name="Deviation" description="Standard deviation of Normal distribution" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.080576347522488" displayUnit="l">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="65" />
+                      </Parameter>
+                      <Container id="QdibKiC6WEiUzhAoSsZy-A" name="Aciclovir" mode="Logical" containerType="Molecule" />
+                    </Children>
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
+                    <Info min="0" flag="106" seq="8" ref="0" bb="32" group="65" />
+                  </DistributedParameter>
+                  <DistributedParameter id="TexyR0DRPkOLyjqaxnRI1A" name="Specific blood flow rate" description="Blood flow rate normalized to the organ volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" formula="cDMsY_IqgUefz2Zb7mLUHg" mode="Logical" isDefault="1" displayUnit="ml/min/100g organ">
+                    <Children>
+                      <Parameter id="VrWBFNTHIEWmzMDuKw5c0A" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="5" />
+                      </Parameter>
+                      <Parameter id="KomNgfukuEiOY9tYkvEcwQ" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.6305" displayUnit="ml/min/100g organ">
+                        <Info min="0" flag="50" seq="1" ref="0" bb="32" group="5" />
+                      </Parameter>
+                      <Parameter id="eMw9GuvSQEygVba3cB57ww" name="Deviation" description="Standard deviation of Normal distribution" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.031525" displayUnit="ml/min/100g organ">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="5" />
+                      </Parameter>
+                      <Container id="hhT-46yBb0mSWGmi-pkLTQ" name="Aciclovir" mode="Logical" containerType="Molecule" />
+                    </Children>
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="40" source="Publication" description="Edginton, A.N., Schmitt, W. &amp; Willmann, S. Clin Pharmacokinet (2006) 45: 1013. https://doi.org/10.2165/00003088-200645100-00005" />
+                    <Info min="0" flag="122" seq="121" ref="0" bb="32" group="5" />
+                  </DistributedParameter>
+                  <Container id="ktOYgOHeEU6lrdTGt7nwtw" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
+                    <Tags>
+                      <Tag value="LargeIntestine" />
+                      <Tag value="Portal Vein Supplying Organ" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="6x_MYEXfxEyEkFD6og_lIw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="WiDWMA7xi02WdVvl1Rjr0g" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="7hDaM_FmK0-MyjtvzRSnGg" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="iKmS3ppFAU-9Z6ITythjAg" isDefault="1" displayUnit="l">
+                        <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
+                        <Info min="0" flag="62" seq="16" ref="0" bb="2" group="126" />
+                      </Parameter>
+                      <MoleculeAmount id="xBdqOfF-E0uoyxfVZCCs3w" name="CYP344" icon="ENZYME" persistable="0" isFixedValue="0" dim="Amount" quantityType="Enzyme" negativeValuesAllowed="0" formula="rMXLZglcaUaofPZ0c6I6Yw" mode="Logical" scaleDivisor="1" displayUnit="µmol">
+                        <Children>
+                          <Parameter id="JqMSQ_TnPECN6L0zlHD4lQ" name="Degradation coefficient" description="First order turnover rate constant of the enzyme" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="c2fNMePAyki4XPdR-AEHaQ" isDefault="1" displayUnit="1/min">
+                            <ValueOrigin id="33" source="Other" description="OSP Suite Manual Chapter 16. PK-Sim®- Compounds: Defining inhibition/induction processes" />
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="5oJISUZMa0STlOOI1R4BTw" name="Relative expression" description="Relative expression" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="fqrxyq94VkWMTLJeRjjhEQ" isDefault="1">
+                            <Info min="0" flag="60" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="-I7A9MWabEmby9dq7L8GJw" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="YQ_SIzoIak2o9B3xCbLazA" isDefault="1">
+                            <Info min="0" flag="58" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="6vpkx_x4Hk64rzmnP6AZGg" name="Relative expression out." description="Relative Expression that will be used in the simulation" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="fbRCNZOks0i0JlaOaYnbvg" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="brH7vH25YUWn2qeXDGVxSw" name="Start amount" description="Start amount of molecule" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" formula="EPX-QNxBZE2pcwiBNY6NfA" isDefault="1" displayUnit="µmol">
+                            <Info flag="54" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="mQ4ogWn4H0GOKSYJqPIZow" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="_5AQF4X5mkuTWnIB24ghvw" isDefault="1" displayUnit="µmol/l">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Parameter id="IixSOQdWyEuJG-RNh64wGg" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="1SRrb94h4Em97B0B9y9azQ" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                          </Parameter>
+                          <Parameter id="TTNd4Q35-kCA9mwbIcmNnA" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="e1yoZQaNG0SuJdQwnaONZQ" isDefault="1" displayUnit="min">
+                            <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Observer id="UGQzCJvXyUS5d2w6P7ApUg" name="Concentration in container" description="Concentration of the molecule" icon="Observer" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Enzyme, Observer" negativeValuesAllowed="1" formula="6wCmGaSt3UirOnRpXv6unA" displayUnit="µmol/l" />
+                        </Children>
+                      </MoleculeAmount>
+                      <MoleculeAmount id="egltpUZO6EWeO7Pbo85uvA" name="Aciclovir" icon="DRUG" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" negativeValuesAllowed="0" mode="Logical" scaleDivisor="1" value="0" displayUnit="µmol">
+                        <Children>
+                          <Parameter id="5KLPMN5-0UqyWbbL6Rdh4g" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="_5AQF4X5mkuTWnIB24ghvw" isDefault="1" displayUnit="µmol/l">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Parameter id="ecRezCTVhEOk-zqAqtVnYg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="HORFEyipOkCOKCoxdeBmYA" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                          </Parameter>
+                          <Observer id="UBKKai8FoU6IIeb0XvUftA" name="Concentration in container" description="Concentration of the molecule" icon="Observer" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" negativeValuesAllowed="1" formula="6wCmGaSt3UirOnRpXv6unA" displayUnit="µmol/l" />
+                        </Children>
+                      </MoleculeAmount>
+                    </Children>
+                  </Container>
+                  <Container id="7kXmyJZiGkOucBYhYbZiPg" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
+                    <Tags>
+                      <Tag value="LargeIntestine" />
+                      <Tag value="Portal Vein Supplying Organ" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="pcTWxthjeUWPBvABqnv5FA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="WiDWMA7xi02WdVvl1Rjr0g" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="8DSBFKzhS0yYDSOpKfy_Mw" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="Mg3W60_RhEm_v4eTI1SOOg" isDefault="1" displayUnit="l">
+                        <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
+                        <Info min="0" flag="62" seq="16" ref="0" bb="2" group="121" />
+                      </Parameter>
+                      <MoleculeAmount id="9ISh5ncwpUahmepcU-m-6Q" name="CYP344" icon="ENZYME" persistable="0" isFixedValue="0" dim="Amount" quantityType="Enzyme" negativeValuesAllowed="0" formula="rMXLZglcaUaofPZ0c6I6Yw" mode="Logical" scaleDivisor="1" displayUnit="µmol">
+                        <Children>
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+                            <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
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+                          <Parameter id="iElkOYwdnU2av6m0xSIuRA" name="Fraction vascular" description="Fraction of vascular space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.13">
+                            <Info min="0" max="1" flag="62" seq="348" ref="0" bb="32" group="64" />
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+                          <Parameter id="7sfCH7TyzEikvEhgRd6wog" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.06">
+                            <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
+                            <Info min="0" max="1" flag="122" seq="348" ref="0" bb="32" group="85" />
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+                            <Info min="0" max="1" flag="122" seq="348" ref="0" bb="32" group="86" />
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+                          <Parameter id="PGxgNbzeNkegb6-rtKnHrg" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0163">
+                            <Info min="0" max="1" flag="122" seq="349" ref="0" bb="32" group="86" />
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+                          <Parameter id="U16RlT64kUCyyUNrhsXiTA" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.08">
+                            <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
+                            <Info min="0" max="1" flag="122" seq="349" ref="0" bb="32" group="85" />
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+                            <Info min="0" max="1" flag="62" seq="350" ref="0" bb="32" group="64" />
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+                          <Parameter id="wo2idtNlNka8cRMWc4sz7Q" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.158">
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+                            <Info min="0" max="1" flag="122" seq="581" ref="0" bb="32" group="92" />
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+                            <Info min="0" max="1" flag="122" seq="582" ref="0" bb="32" group="92" />
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+                          <Parameter id="P_3GCA_L60-5J7_Xwb5s3w" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.456">
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+                            <Info min="0" max="1000" flag="122" seq="584" ref="0" bb="32" group="92" />
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+                            </Tags>
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+                                    <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
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+                                  <Parameter id="fKWeUAiWH06CXnz3a_iaGg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="yhaw1bRR5EuEMtjrCcWzWw" isDefault="1">
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+                                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
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+                          <Parameter id="CtN2faOxd0e16YhgH4HH8Q" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0163">
+                            <Info min="0" max="1" flag="122" seq="352" ref="0" bb="32" group="86" />
+                          </Parameter>
+                          <Parameter id="exYVGHP-K0mA6koJLfvTqg" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.08">
+                            <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
+                            <Info min="0" max="1" flag="122" seq="352" ref="0" bb="32" group="85" />
+                          </Parameter>
+                          <Parameter id="ZG5suuskS0i6sKisGpUIBg" name="Fraction interstitial" description="Fraction of interstitial space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.73">
+                            <Info min="0" max="1" flag="62" seq="353" ref="0" bb="32" group="64" />
+                          </Parameter>
+                          <Parameter id="YS7al0mf8keY8QrQXQIxCA" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.158">
+                            <ValueOrigin id="22" source="Publication" description="Rodgers T, Rowland M. Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J Pharm Sci. 2006 Jun;95(6):1238-57 https://doi.org/10.1002/jps.20502" />
+                            <Info min="0" max="1" flag="122" seq="353" ref="0" bb="32" group="111" />
+                          </Parameter>
+                          <Parameter id="DQYG3k4ogkuQwzgJJxFEKw" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                            <ValueOrigin id="24" source="Publication" description="POULIN P, THEIL F. Prediction of Pharmacokinetics Prior to In Vivo Studies. 1. Mechanism-Based Prediction of Volume of Distribution. JOURNAL OF PHARMACEUTICAL SCIENCES, VOL. 91, NO. 1, JANUARY 2002" />
+                            <Info min="0" max="1" flag="122" seq="353" ref="0" bb="32" group="112" />
+                          </Parameter>
+                          <Parameter id="131lIGgh5UiXas9X0CeFCQ" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.141">
+                            <ValueOrigin id="22" source="Publication" description="Rodgers T, Rowland M. Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J Pharm Sci. 2006 Jun;95(6):1238-57 https://doi.org/10.1002/jps.20502" />
+                            <Info min="0" max="1" flag="122" seq="353" ref="0" bb="32" group="113" />
+                          </Parameter>
+                          <Parameter id="shXnqJIiFEusxhktLp4guw" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.8">
+                            <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
+                            <Info min="0" max="1" flag="122" seq="353" ref="0" bb="32" group="85" />
+                          </Parameter>
+                          <Parameter id="F9i-BrmQC0yC8vkjr0WBmw" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.718">
+                            <Info min="0" max="1" flag="122" seq="353" ref="0" bb="32" group="86" />
+                          </Parameter>
+                          <Parameter id="Q2vFHJwxKEO4ChP1mHYNOA" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0375">
+                            <ValueOrigin id="22" source="Publication" description="Rodgers T, Rowland M. Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J Pharm Sci. 2006 Jun;95(6):1238-57 https://doi.org/10.1002/jps.20502" />
+                            <Info min="0" max="1" flag="122" seq="585" ref="0" bb="32" group="92" />
+                          </Parameter>
+                          <Parameter id="y1j5kV-AiEuTrOWsxY9sjg" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0483">
+                            <Info min="0" max="1" flag="122" seq="585" ref="0" bb="32" group="95" />
+                          </Parameter>
+                          <Parameter id="_-AQdcdo_0WqKpkoGEGNKg" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0124">
+                            <ValueOrigin id="22" source="Publication" description="Rodgers T, Rowland M. Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J Pharm Sci. 2006 Jun;95(6):1238-57 https://doi.org/10.1002/jps.20502" />
+                            <Info min="0" max="1" flag="122" seq="586" ref="0" bb="32" group="92" />
+                          </Parameter>
+                          <Parameter id="j1qCN3Yy10m7BKpMnm-3dQ" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0182">
+                            <Info min="0" max="1" flag="122" seq="586" ref="0" bb="32" group="95" />
+                          </Parameter>
+                          <Parameter id="7BrPkRVSyEOk8e8m50B7ow" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.282">
+                            <ValueOrigin id="21" source="Publication" description="Rodgers T, Leahy D, Rowland M. Physiologically based pharmacokinetic modeling 1: predicting the tissue distribution of moderate-to-strong bases. J Pharm Sci. 2005 Jun;94(6):1259-76. https://doi.org/10.1002/jps.20322" />
+                            <Info min="0" max="1" flag="122" seq="587" ref="0" bb="32" group="92" />
+                          </Parameter>
+                          <Parameter id="6UYb_ye9VUmON6ljvQxdaQ" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.15">
+                            <Info min="0" max="1" flag="122" seq="587" ref="0" bb="32" group="95" />
+                          </Parameter>
+                          <Parameter id="5zv9b61hvU-chqS5vRnv1g" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.456">
+                            <ValueOrigin id="22" source="Publication" description="Rodgers T, Rowland M. Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J Pharm Sci. 2006 Jun;95(6):1238-57 https://doi.org/10.1002/jps.20502" />
+                            <Info min="0" max="1" flag="122" seq="588" ref="0" bb="32" group="92" />
+                          </Parameter>
+                          <Parameter id="vHRr0K_8akyYXyuwAXGKaQ" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.78">
+                            <Info min="0" max="1" flag="122" seq="588" ref="0" bb="32" group="95" />
+                          </Parameter>
+                          <Parameter id="XuLh6xDGL0--o3Ab6ZTtpg" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.41">
+                            <ValueOrigin id="21" source="Publication" description="Rodgers T, Leahy D, Rowland M. Physiologically based pharmacokinetic modeling 1: predicting the tissue distribution of moderate-to-strong bases. J Pharm Sci. 2005 Jun;94(6):1259-76. https://doi.org/10.1002/jps.20322" />
+                            <Info min="0" max="1000" flag="122" seq="589" ref="0" bb="32" group="92" />
+                          </Parameter>
+                          <Parameter id="mFfsF11t7kS5k2OLugJLAA" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0035">
+                            <Info min="0" max="1" flag="122" seq="589" ref="0" bb="32" group="95" />
+                          </Parameter>
+                          <Container id="3IX6ZvrqBE2RAum9H4_lpw" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
+                            <Tags>
+                              <Tag value="ColonAscendens" />
+                              <Tag value="LargeIntestineSegment" />
+                              <Tag value="Mucosa" />
+                            </Tags>
+                            <Children>
+                              <Parameter id="9Wt7wWMXuUit9xGROtgPlQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="WiDWMA7xi02WdVvl1Rjr0g" isDefault="1" displayUnit="l">
+                                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                              </Parameter>
+                              <Parameter id="hE36XP-nnk-IBmzzS8YKyg" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="yYX4DjDwkEOGUvd-DF06pA" isDefault="1" displayUnit="l">
+                                <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                                <Info min="0" flag="62" seq="117" ref="0" bb="2" group="126" />
+                              </Parameter>
+                              <MoleculeAmount id="gvi1fSUug02T0V0yhQRbhw" name="CYP344" icon="ENZYME" persistable="0" isFixedValue="0" dim="Amount" quantityType="Enzyme" negativeValuesAllowed="0" formula="rMXLZglcaUaofPZ0c6I6Yw" mode="Logical" scaleDivisor="1" displayUnit="µmol">
+                                <Children>
+                                  <Parameter id="_neFIF052ECc5CmaQyFDYg" name="Degradation coefficient" description="First order turnover rate constant of the enzyme" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="c2fNMePAyki4XPdR-AEHaQ" isDefault="1" displayUnit="1/min">
+                                    <ValueOrigin id="33" source="Other" description="OSP Suite Manual Chapter 16. PK-Sim®- Compounds: Defining inhibition/induction processes" />
+                                    <Info min="0" flag="52" seq="1" ref="0" bb="2" group="91" />
+                                  </Parameter>
+                                  <Parameter id="exAEpkQgmE6VLkbNmrRqNA" name="Relative expression" description="Relative expression" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="fqrxyq94VkWMTLJeRjjhEQ" isDefault="1">
+                                    <Info min="0" flag="60" seq="1" ref="0" bb="2" group="91" />
+                                  </Parameter>
+                                  <Parameter id="KQ3TjOXVekWH4KAEf_b_Kw" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="YQ_SIzoIak2o9B3xCbLazA" isDefault="1">
+                                    <Info min="0" flag="58" seq="1" ref="0" bb="2" group="91" />
+                                  </Parameter>
+                                  <Parameter id="fbJtS-U2zkSrNv6c-qAA2g" name="Relative expression out." description="Relative Expression that will be used in the simulation" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="fbRCNZOks0i0JlaOaYnbvg" isDefault="1">
+                                    <Info min="0" flag="52" seq="1" ref="0" bb="2" group="91" />
+                                  </Parameter>
+                                  <Parameter id="RRrz-9mEgE6dhiIfW8ch2A" name="Start amount" description="Start amount of molecule" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" formula="EPX-QNxBZE2pcwiBNY6NfA" isDefault="1" displayUnit="µmol">
+                                    <Info flag="54" seq="1" ref="0" bb="2" group="91" />
+                                  </Parameter>
+                                  <Parameter id="nFkJixp0i0Cr4wAWUXz1gg" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="_5AQF4X5mkuTWnIB24ghvw" isDefault="1" displayUnit="µmol/l">
+                                    <Info min="0" flag="18" seq="1" ref="0" bb="2" group="117" />
+                                  </Parameter>
+                                  <Parameter id="EtQNBVKpVkGDL0QveD57xw" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DiXGiDOMPEC-LnEd2E0TQw" isDefault="1">
+                                    <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                                  </Parameter>
+                                  <Parameter id="jc0v_5daBUKhvBQ25ehogg" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="cCDpj4FAqU6Ryn2QlLDAxw" isDefault="1" displayUnit="min">
+                                    <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                                  </Parameter>
+                                  <Observer id="KDpXfY2ZlUmH8heyv-dhHw" name="Concentration in container" description="Concentration of the molecule" icon="Observer" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Enzyme, Observer" negativeValuesAllowed="1" formula="6wCmGaSt3UirOnRpXv6unA" displayUnit="µmol/l" />
+                                </Children>
+                              </MoleculeAmount>
+                              <MoleculeAmount id="gdVc1LkaqUKWwNPeWpWNFA" name="Aciclovir" icon="DRUG" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" negativeValuesAllowed="0" mode="Logical" scaleDivisor="1" value="0" displayUnit="µmol">
+                                <Children>
+                                  <Parameter id="X2c8oXoGJUKXI-A-syxmbg" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="_5AQF4X5mkuTWnIB24ghvw" isDefault="1" displayUnit="µmol/l">
+                                    <Info min="0" flag="18" seq="1" ref="0" bb="2" group="117" />
+                                  </Parameter>
+                                  <Parameter id="R51ON7U1vk63o0S3H5z1yQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lo8TiYr9wEaidgpFQertZg" isDefault="1">
+                                    <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                                  </Parameter>
+                                  <Observer id="5lqwYA7OHki6rl0i029Khw" name="Concentration in container" description="Concentration of the molecule" icon="Observer" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" negativeValuesAllowed="1" formula="6wCmGaSt3UirOnRpXv6unA" displayUnit="µmol/l" />
+                                </Children>
+                              </MoleculeAmount>
+                            </Children>
+                          </Container>
+                          <Container id="fY5-Tz2cDk-SgbOQbDDDkQ" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
+                            <Tags>
+                              <Tag value="ColonAscendens" />
+                              <Tag value="LargeIntestineSegment" />
+                              <Tag value="Mucosa" />
+                            </Tags>
+                            <Children>
+                              <Parameter id="aobzLJWatUybQTnIbGoYZg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="WiDWMA7xi02WdVvl1Rjr0g" isDefault="1" displayUnit="l">
+                                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                              </Parameter>
+                              <Parameter id="q5NKgRTkIkC1yy-HNBQnxA" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="H_SN9-_mbUGRPDaFmFf1dQ" isDefault="1" displayUnit="l">
+                                <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                                <Info min="0" flag="62" seq="117" ref="0" bb="2" group="121" />
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+                              <MoleculeAmount id="7WP4fSkbQE6NEgbw8_hCVw" name="CYP344" icon="ENZYME" persistable="0" isFixedValue="0" dim="Amount" quantityType="Enzyme" negativeValuesAllowed="0" formula="rMXLZglcaUaofPZ0c6I6Yw" mode="Logical" scaleDivisor="1" displayUnit="µmol">
+                                <Children>
+                                  <Parameter id="jqJdUZtZxUWWToxZYMViRQ" name="Degradation coefficient" description="First order turnover rate constant of the enzyme" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="c2fNMePAyki4XPdR-AEHaQ" isDefault="1" displayUnit="1/min">
+                                    <ValueOrigin id="33" source="Other" description="OSP Suite Manual Chapter 16. PK-Sim®- Compounds: Defining inhibition/induction processes" />
+                                    <Info min="0" flag="52" seq="1" ref="0" bb="2" group="91" />
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+                                  <Parameter id="CAOAGC1fQEOstoT8nKbp_w" name="Relative expression" description="Relative expression" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="cLw6IJb0kk-aHdh1YkXHkw" isDefault="1">
+                                    <Info min="0" flag="60" seq="1" ref="0" bb="2" group="91" />
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+                                  <Parameter id="_oXvdLIZKUSo2oOHRZpxhw" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="xTktpLRZC0e7-rlZenlyLg" isDefault="1">
+                                    <Info min="0" flag="58" seq="1" ref="0" bb="2" group="91" />
+                                  </Parameter>
+                                  <Parameter id="Nnaus-hXu0qMTtH1HfPwLA" name="Relative expression out." description="Relative Expression that will be used in the simulation" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="fbRCNZOks0i0JlaOaYnbvg" isDefault="1">
+                                    <Info min="0" flag="52" seq="1" ref="0" bb="2" group="91" />
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+                                  <Parameter id="ATeMEwmGv0SMzAh6-xiIRg" name="Start amount" description="Start amount of molecule" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" formula="EPX-QNxBZE2pcwiBNY6NfA" isDefault="1" displayUnit="µmol">
+                                    <Info flag="54" seq="1" ref="0" bb="2" group="91" />
+                                  </Parameter>
+                                  <Parameter id="GxJHGVSR2UyJAgMuw87Qeg" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="_5AQF4X5mkuTWnIB24ghvw" isDefault="1" displayUnit="µmol/l">
+                                    <Info min="0" flag="18" seq="1" ref="0" bb="2" group="117" />
+                                  </Parameter>
+                                  <Parameter id="3vXPAlA-wEGOqBwXjFPKgw" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="dC8_dX76j0Ga22udd0dc4Q" isDefault="1">
+                                    <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                                  </Parameter>
+                                  <Parameter id="KMrWDy-AD06kgokTUIjMig" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="LHpnYSQ2eEK5-LmTnfh6XQ" isDefault="1" displayUnit="min">
+                                    <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                                  </Parameter>
+                                  <Observer id="a75ANu5q8UuSwFEiF3XpLw" name="Concentration in container" description="Concentration of the molecule" icon="Observer" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Enzyme, Observer" negativeValuesAllowed="1" formula="6wCmGaSt3UirOnRpXv6unA" displayUnit="µmol/l" />
+                                </Children>
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+                              <MoleculeAmount id="wSMMb12yZkCZl46czAda2g" name="Aciclovir" icon="DRUG" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" negativeValuesAllowed="0" mode="Logical" scaleDivisor="1" value="0" displayUnit="µmol">
+                                <Children>
+                                  <Parameter id="2EkYfPW8rEKZO3UAUjJZ8Q" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="_5AQF4X5mkuTWnIB24ghvw" isDefault="1" displayUnit="µmol/l">
+                                    <Info min="0" flag="18" seq="1" ref="0" bb="2" group="117" />
+                                  </Parameter>
+                                  <Parameter id="tEiZNFWVQU6gGi9IKtHf-g" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="cEK2PJseYkGmnUUEJUsD_g" isDefault="1">
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+                            <Info min="0" max="1" flag="122" seq="356" ref="0" bb="32" group="111" />
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+                          <Parameter id="emcnrHVGh0apPytNpm9Mag" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                            <ValueOrigin id="24" source="Publication" description="POULIN P, THEIL F. Prediction of Pharmacokinetics Prior to In Vivo Studies. 1. Mechanism-Based Prediction of Volume of Distribution. JOURNAL OF PHARMACEUTICAL SCIENCES, VOL. 91, NO. 1, JANUARY 2002" />
+                            <Info min="0" max="1" flag="122" seq="356" ref="0" bb="32" group="112" />
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+                          <Parameter id="cGl9CK2xDkmuErk1SXrbVQ" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.141">
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+                            <Info min="0" max="1" flag="122" seq="356" ref="0" bb="32" group="113" />
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+                          <Parameter id="k1haOeQexU2_-zNbRlF9hQ" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.8">
+                            <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
+                            <Info min="0" max="1" flag="122" seq="356" ref="0" bb="32" group="85" />
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+                          <Parameter id="GGUEUlfYOUyyo3kHCKx_Uw" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.718">
+                            <Info min="0" max="1" flag="122" seq="356" ref="0" bb="32" group="86" />
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+                          <Parameter id="gJCQNF_pR0ypOMx-2k2Ipw" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0375">
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+                            <Info min="0" max="1" flag="122" seq="590" ref="0" bb="32" group="92" />
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+                            <Info min="0" max="1" flag="122" seq="591" ref="0" bb="32" group="92" />
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+                          <Parameter id="ufTOH_NU_kCMSLumVemkDg" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.282">
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+                            <Info min="0" max="1" flag="122" seq="592" ref="0" bb="32" group="92" />
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+                          <Parameter id="G_fF3CTrKUqOAmLvE-ropw" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.456">
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+                            <Info min="0" max="1000" flag="122" seq="594" ref="0" bb="32" group="92" />
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+                          <Parameter id="EveTAHVbAEeBLDTj4l18Aw" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0035">
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+                              <Tag value="LargeIntestineSegment" />
+                              <Tag value="Mucosa" />
+                            </Tags>
+                            <Children>
+                              <Parameter id="vlpN3q-y5Uu115rzmq-8BQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="WiDWMA7xi02WdVvl1Rjr0g" isDefault="1" displayUnit="l">
+                                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
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+                                  <Parameter id="hnIQ863nLUWLx4hXPp5kjQ" name="Degradation coefficient" description="First order turnover rate constant of the enzyme" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="c2fNMePAyki4XPdR-AEHaQ" isDefault="1" displayUnit="1/min">
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+                                    <Info min="0" flag="52" seq="1" ref="0" bb="2" group="91" />
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+                                    <Info flag="54" seq="1" ref="0" bb="2" group="91" />
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+                                  <Parameter id="dzAv71C6I0aEK7RrkmcYOg" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="_5AQF4X5mkuTWnIB24ghvw" isDefault="1" displayUnit="µmol/l">
+                                    <Info min="0" flag="18" seq="1" ref="0" bb="2" group="117" />
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+                                  <Parameter id="la4OgDJ-x0CpuqsocDRxrg" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="co5OwBijwk-b7_Kszz9T6w" isDefault="1">
+                                    <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
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+                                  <Parameter id="amMoj6c7GUKOoVzGea21ww" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="GpL8bLDPJU2pdUs2ZlRxxg" isDefault="1" displayUnit="min">
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+                                  <Parameter id="E4_QDIO3wEe5cU1aHIPAoA" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="_5AQF4X5mkuTWnIB24ghvw" isDefault="1" displayUnit="µmol/l">
+                                    <Info min="0" flag="18" seq="1" ref="0" bb="2" group="117" />
+                                  </Parameter>
+                                  <Parameter id="CD1e2efz2k6-v1rnAvOp9Q" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="vHKeGmaxT0K1TSkpFV-T8g" isDefault="1">
+                                    <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
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+                              <Tag value="ColonTransversum" />
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+                                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
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+                              <Parameter id="91-p4WP1sk-f6ykzLmodgw" name="pH" description="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="eK4DKfgMbEONwPdNpejUig" isDefault="1">
+                                <Tags>
+                                  <Tag value="ColonTransversum" />
+                                  <Tag value="LargeIntestineSegment" />
+                                  <Tag value="Mucosa" />
+                                </Tags>
+                                <Info min="0" max="14" flag="122" seq="356" ref="0" bb="32" group="84" />
+                              </Parameter>
+                              <MoleculeAmount id="nD6Ye-w4p0OvnbeePD57qQ" name="Aciclovir" icon="DRUG" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" negativeValuesAllowed="0" mode="Logical" scaleDivisor="1" value="0" displayUnit="µmol">
+                                <Children>
+                                  <Parameter id="H8PJsPuRnEyc-Rzwd6XulA" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="_5AQF4X5mkuTWnIB24ghvw" isDefault="1" displayUnit="µmol/l">
+                                    <Info min="0" flag="18" seq="1" ref="0" bb="2" group="117" />
+                                  </Parameter>
+                                  <Parameter id="RlrshU6jYkqw7AD7EuMK9g" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="3gnBWIvxTE6fkZgJPMD6eQ" isDefault="1">
+                                    <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                                  </Parameter>
+                                  <Observer id="wq2AUMaPp0mr6MvkTXzwUA" name="Concentration in container" description="Concentration of the molecule" icon="Observer" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" negativeValuesAllowed="1" formula="6wCmGaSt3UirOnRpXv6unA" displayUnit="µmol/l" />
+                                </Children>
+                              </MoleculeAmount>
+                            </Children>
+                          </Container>
+                          <Container id="K_DTJO3kn0WFG-dPb6WJzw" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
+                            <Tags>
+                              <Tag value="ColonTransversum" />
+                              <Tag value="IntestinalSecretionSource" />
+                              <Tag value="LargeIntestineSegment" />
+                              <Tag value="Mucosa" />
+                            </Tags>
+                            <Children>
+                              <Parameter id="wI7YgHWLXki67ndOT_9Bvg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="J_zsXA_hVEGtRM46zqPvJg" isDefault="1" displayUnit="l">
+                                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                              </Parameter>
+                              <Parameter id="KM33UgQpCk6Zwny_XR2xvA" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="GXZJgB5-lEOADgF16J9WjQ" isDefault="1" displayUnit="l">
+                                <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                                <Info min="0" flag="62" seq="118" ref="0" bb="2" group="125" />
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+                                <Tags>
+                                  <Tag value="ColonTransversum" />
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+                                <Info min="0" max="14" flag="122" seq="356" ref="0" bb="32" group="83" />
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+                              <MoleculeAmount id="VM_HIEzu-kSRKJRD_effYg" name="CYP344" icon="ENZYME" persistable="0" isFixedValue="0" dim="Amount" quantityType="Enzyme" negativeValuesAllowed="0" formula="rMXLZglcaUaofPZ0c6I6Yw" mode="Logical" scaleDivisor="1" displayUnit="µmol">
+                                <Children>
+                                  <Parameter id="7_2BxpnerkafTOUI3a9xqA" name="Degradation coefficient" description="First order turnover rate constant of the enzyme" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="c2fNMePAyki4XPdR-AEHaQ" isDefault="1" displayUnit="1/min">
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+                                  <Parameter id="Vsavby7SNUm8JFcKFyN4kg" name="Relative expression" description="Relative expression" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0">
+                                    <Info min="0" flag="60" seq="1" ref="0" bb="32" group="91" />
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+                                  <Parameter id="rj-ze9EXBUavMTbJNhhkcw" name="Relative expression out." description="Relative Expression that will be used in the simulation" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="fbRCNZOks0i0JlaOaYnbvg" isDefault="1">
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+                                    <Info flag="54" seq="1" ref="0" bb="2" group="91" />
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+                                  <Parameter id="ljb6otfZakqWuMRj5_uVoQ" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="_5AQF4X5mkuTWnIB24ghvw" isDefault="1" displayUnit="µmol/l">
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+                                  <Parameter id="rrdtUHL0Fki2gKqZ-kQG5g" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="3VayxOgowE23Qm7Q9-MBIg" isDefault="1">
+                                    <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
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+                                  <Parameter id="RqweTXVD9kaHNIPToAKo5g" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="Df4vMpYADkWM-qLKfgZz_w" isDefault="1" displayUnit="min">
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+                                  </Parameter>
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+                                </Children>
+                              </MoleculeAmount>
+                              <MoleculeAmount id="WXFcEn0RZU-hAd-SnN8AKQ" name="Aciclovir" icon="DRUG" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" negativeValuesAllowed="0" mode="Logical" scaleDivisor="1" value="0" displayUnit="µmol">
+                                <Children>
+                                  <Parameter id="89vSb0r6J0iOjStSPjt2AQ" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="_5AQF4X5mkuTWnIB24ghvw" isDefault="1" displayUnit="µmol/l">
+                                    <Info min="0" flag="18" seq="1" ref="0" bb="2" group="117" />
+                                  </Parameter>
+                                  <Parameter id="FuIoKbdzSE2zIs2JJndtVA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="FZZXQR-NPEy8aVaF_N_4TA" isDefault="1">
+                                    <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                                  </Parameter>
+                                  <Observer id="YhCwkfR01UaG73E1EMHTXQ" name="Concentration in container" description="Concentration of the molecule" icon="Observer" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" negativeValuesAllowed="1" formula="6wCmGaSt3UirOnRpXv6unA" displayUnit="µmol/l" />
+                                </Children>
+                              </MoleculeAmount>
+                            </Children>
+                          </Container>
+                        </Children>
+                      </Container>
+                      <Container id="8qEnmiNJ4Emo_ODahGJTag" name="ColonDescendens" description="Colon Descendens / Distal Colon 1" icon="ColonDescendens" mode="Logical" containerType="Compartment">
+                        <Children>
+                          <Parameter id="lORt51MRT0WUVUEw4W2OHQ" name="Weight (tissue)" description="Weight of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="fliUWazsPUiRy_qjzM6EaA" isDefault="1" displayUnit="kg">
+                            <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
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+                          <Parameter id="QQyQlOHMrEW5bCJ6xrw17w" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="uUgAVxtJ1E6I_zeJpjUK4g" isDefault="1" displayUnit="l">
+                            <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
+                            <Info min="0" flag="122" seq="28" ref="0" bb="32" group="65" />
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+                          <Parameter id="mlJCuGiRV0eWfFrfgYG7zg" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="QlYSvoeuX02TuHXPVFZCtA" isDefault="1" displayUnit="l/min">
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+                          <Parameter id="PBmfNV4BPEmgcO-thwVi2g" name="Lymph flow rate" description="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="d1cVNZytnE2lcqXnxo351w" isDefault="1" displayUnit="l/min">
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+                          <Parameter id="sIbQlujgXU6JNmfFAjRpHA" name="Volume (endothelium)" description="Volume of  vascular endothelium" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="Y0IEAp3FbUCWv_aRBTPYwQ" isDefault="1" displayUnit="l">
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+                          <Parameter id="NHCRTlOJEEeQpd01hnqMUA" name="Blood flow rate" description="Organ blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="zgx06UYiLE-TFvmfLI4jxA" isDefault="1" displayUnit="l/min">
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+                            <Info min="0" flag="122" seq="308" ref="0" bb="32" group="5" />
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+                          <Parameter id="sDQ2pBA84EavyTmA2cbaBg" name="Fraction intracellular" description="Fraction of intracellular space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="I-HZynBcWEaZVIcFkF3iMQ" isDefault="1">
+                            <Info min="0" max="1" flag="62" seq="358" ref="0" bb="32" group="64" />
+                          </Parameter>
+                          <Parameter id="AMhj_TaEA0etQpFA5FmAZg" name="Density (tissue)" description="Density of tissue" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
+                            <Info min="0" flag="38" seq="1" ref="0" bb="32" group="21" />
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+                          <Parameter id="gORy1_PRLkmwoAE4r7PlqA" name="Fraction mucosa" description="Mucosal fraction of regional intestinal tissue mass" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.14">
+                            <Info min="0" max="1" flag="122" seq="1" ref="0" bb="32" group="40" />
+                          </Parameter>
+                          <Parameter id="T_AwusIfU0-ddlU2hOQUTQ" name="Fraction of regional blood flow rate" description="Regional blood flow fraction supplying the mucosal tissue of the segment" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.24">
+                            <Info min="0" flag="54" seq="1" ref="0" bb="32" group="39" />
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+                          <Parameter id="-80Gy8YaEUGRUp1qRqEsdA" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                            <Info min="0" max="1" flag="54" seq="1" ref="0" bb="32" group="94" />
+                          </Parameter>
+                          <Parameter id="56Svi1vix0GUTGFSH3RysA" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.05">
+                            <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                            <Info min="0" max="1" flag="122" seq="119" ref="0" bb="32" group="114" />
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+                          <Parameter id="M6z-yOSSDkmfdiQHToB7Tg" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" icon="Parameter" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.86944444444444E-10" displayUnit="ml/min/N">
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+                          <Parameter id="mb_p1oxTvEW9HXuQLmCO6w" name="Radius (large pores)" description="Large endothelial pores radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.5E-07" displayUnit="µm">
+                            <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
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+                            <Info min="0" flag="122" seq="119" ref="0" bb="32" group="99" />
+                          </Parameter>
+                          <Parameter id="oaXe4UYNwUW6iKmlf9_Thg" name="Fraction vascular" description="Fraction of vascular space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.12">
+                            <Info min="0" max="1" flag="62" seq="357" ref="0" bb="32" group="64" />
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+                          <Parameter id="vAQmyA5f2E6Jei1ewQON8A" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.06">
+                            <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
+                            <Info min="0" max="1" flag="122" seq="357" ref="0" bb="32" group="85" />
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+                          <Parameter id="pVxuqulVQkmvwLjLcj158w" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0487">
+                            <Info min="0" max="1" flag="122" seq="357" ref="0" bb="32" group="86" />
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+                            <Info min="0" max="1" flag="122" seq="358" ref="0" bb="32" group="86" />
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+                            <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
+                            <Info min="0" max="1" flag="122" seq="358" ref="0" bb="32" group="85" />
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+                          <Parameter id="0njFxsKn6k2cOa0OU2wpAg" name="Fraction interstitial" description="Fraction of interstitial space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.74">
+                            <Info min="0" max="1" flag="62" seq="359" ref="0" bb="32" group="64" />
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+                          <Parameter id="nyi9FAlBsEaGqFR6YC2pmg" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.158">
+                            <ValueOrigin id="22" source="Publication" description="Rodgers T, Rowland M. Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J Pharm Sci. 2006 Jun;95(6):1238-57 https://doi.org/10.1002/jps.20502" />
+                            <Info min="0" max="1" flag="122" seq="359" ref="0" bb="32" group="111" />
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+                          <Parameter id="eOtGJK2glUOVYwoSDLEkDA" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                            <ValueOrigin id="24" source="Publication" description="POULIN P, THEIL F. Prediction of Pharmacokinetics Prior to In Vivo Studies. 1. Mechanism-Based Prediction of Volume of Distribution. JOURNAL OF PHARMACEUTICAL SCIENCES, VOL. 91, NO. 1, JANUARY 2002" />
+                            <Info min="0" max="1" flag="122" seq="359" ref="0" bb="32" group="112" />
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+                          <Parameter id="Vb3hETkBsUqDBktfED3axA" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.141">
+                            <ValueOrigin id="22" source="Publication" description="Rodgers T, Rowland M. Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J Pharm Sci. 2006 Jun;95(6):1238-57 https://doi.org/10.1002/jps.20502" />
+                            <Info min="0" max="1" flag="122" seq="359" ref="0" bb="32" group="113" />
+                          </Parameter>
+                          <Parameter id="pS9FgDgzB0uC2DBtbr4egQ" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.8">
+                            <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
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+                            <Tags>
+                              <Tag value="ColonDescendens" />
+                              <Tag value="IntestinalSecretionSource" />
+                              <Tag value="LargeIntestineSegment" />
+                              <Tag value="Mucosa" />
+                            </Tags>
+                            <Children>
+                              <Parameter id="H51AH3s3-EG7J4Ao8zP-AA" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="J_zsXA_hVEGtRM46zqPvJg" isDefault="1" displayUnit="l">
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+                              <Parameter id="FD-MUIeixk6TMxRxh0qc4w" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="GXZJgB5-lEOADgF16J9WjQ" isDefault="1" displayUnit="l">
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+                                <Info min="0" flag="62" seq="119" ref="0" bb="2" group="125" />
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+                              <Parameter id="kleZPInWQECI3q92NKBr2g" name="pH" description="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="7.3">
+                                <Tags>
+                                  <Tag value="ColonDescendens" />
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+                                  <Parameter id="4QNqNYluykqTCDDpSPMFGA" name="Degradation coefficient" description="First order turnover rate constant of the enzyme" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="c2fNMePAyki4XPdR-AEHaQ" isDefault="1" displayUnit="1/min">
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+                                  <Parameter id="cUsu_jR1EUeKVM3_y3q0Mg" name="Relative expression" description="Relative expression" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0">
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+                                  <Parameter id="VuFTK1ck8UCuNDpso4st2Q" name="Relative expression out." description="Relative Expression that will be used in the simulation" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="fbRCNZOks0i0JlaOaYnbvg" isDefault="1">
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+                                  <Parameter id="nvthvj-zzUqrx-2RHzE__Q" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="_5AQF4X5mkuTWnIB24ghvw" isDefault="1" displayUnit="µmol/l">
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+                                    <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
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+                                  <Parameter id="dN5ksRIJJkGkNzBdDo4W-Q" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="ZQhWlq0UCUO2CRdvEVQxTA" isDefault="1" displayUnit="min">
+                                    <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                                  </Parameter>
+                                  <Observer id="YlHvdKBcKUKrgJNQ-QzOMQ" name="Concentration in container" description="Concentration of the molecule" icon="Observer" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Enzyme, Observer" negativeValuesAllowed="1" formula="6wCmGaSt3UirOnRpXv6unA" displayUnit="µmol/l" />
+                                </Children>
+                              </MoleculeAmount>
+                              <MoleculeAmount id="RLjjqtjktUmVEZwhOKiC5w" name="Aciclovir" icon="DRUG" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" negativeValuesAllowed="0" mode="Logical" scaleDivisor="1" value="0" displayUnit="µmol">
+                                <Children>
+                                  <Parameter id="7HR9gwrPaU6y3a467sep_A" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="_5AQF4X5mkuTWnIB24ghvw" isDefault="1" displayUnit="µmol/l">
+                                    <Info min="0" flag="18" seq="1" ref="0" bb="2" group="117" />
+                                  </Parameter>
+                                  <Parameter id="1_j6hLguSkmAplQWBBUjNQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ei6qDLcD20SAUJUijWHBZw" isDefault="1">
+                                    <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                                  </Parameter>
+                                  <Observer id="SMv9Mdj-b0yGMI1kx7DjZg" name="Concentration in container" description="Concentration of the molecule" icon="Observer" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" negativeValuesAllowed="1" formula="6wCmGaSt3UirOnRpXv6unA" displayUnit="µmol/l" />
+                                </Children>
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+                          <Parameter id="hQ8gPNj4j0W8KkykyIlhgg" name="Weight (tissue)" description="Weight of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="fliUWazsPUiRy_qjzM6EaA" isDefault="1" displayUnit="kg">
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+                          <Parameter id="olt_XiVqOEOEhQ4Vyd0csQ" name="Volume (endothelium)" description="Volume of  vascular endothelium" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="6QkxK4VhwEaiOgBunceQCQ" isDefault="1" displayUnit="l">
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+                          <Parameter id="Ym1H52ORcEiwF5OUCPmDbw" name="Blood flow rate" description="Organ blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="zgx06UYiLE-TFvmfLI4jxA" isDefault="1" displayUnit="l/min">
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+                            <Info min="0" flag="122" seq="309" ref="0" bb="32" group="5" />
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+                          <Parameter id="RnOHblyTVU6LtxCZDkGDSg" name="Fraction intracellular" description="Fraction of intracellular space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="I-HZynBcWEaZVIcFkF3iMQ" isDefault="1">
+                            <Info min="0" max="1" flag="62" seq="361" ref="0" bb="32" group="64" />
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+                          <Parameter id="jnTYmzMuJk6MyzE1tdrIzg" name="Density (tissue)" description="Density of tissue" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
+                            <Info min="0" flag="38" seq="1" ref="0" bb="32" group="21" />
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+                          <Parameter id="6ktH5l_ry0iN8S9KIIwqDQ" name="Fraction mucosa" description="Mucosal fraction of regional intestinal tissue mass" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.3">
+                            <Info min="0" max="1" flag="122" seq="1" ref="0" bb="32" group="40" />
+                          </Parameter>
+                          <Parameter id="ZAhPJoutSUyf04doBR_okA" name="Fraction of regional blood flow rate" description="Regional blood flow fraction supplying the mucosal tissue of the segment" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.135">
+                            <Info min="0" flag="54" seq="1" ref="0" bb="32" group="39" />
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+                            <Info min="0" max="1" flag="54" seq="1" ref="0" bb="32" group="94" />
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+                          <Parameter id="WfKj-3UvMEqRkvJQ2q7y1g" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.05">
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+                            <Info min="0" flag="122" seq="120" ref="0" bb="32" group="99" />
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+                          <Parameter id="rVvTgn21ikmijk3KlXwrtg" name="Fraction vascular" description="Fraction of vascular space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.08">
+                            <Info min="0" max="1" flag="62" seq="360" ref="0" bb="32" group="64" />
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+                          <Parameter id="jaRCoEtw3kOI72pibXlacw" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.06">
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+                            <Info min="0" max="1" flag="122" seq="360" ref="0" bb="32" group="85" />
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+                            <Info min="0" max="1" flag="122" seq="361" ref="0" bb="32" group="85" />
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+                            <Info min="0" max="1" flag="62" seq="362" ref="0" bb="32" group="64" />
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+                          <Parameter id="GqnYCMZLbEWAFvUv4s080w" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.158">
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+                            <Info min="0" max="1" flag="122" seq="362" ref="0" bb="32" group="111" />
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+                            <ValueOrigin id="24" source="Publication" description="POULIN P, THEIL F. Prediction of Pharmacokinetics Prior to In Vivo Studies. 1. Mechanism-Based Prediction of Volume of Distribution. JOURNAL OF PHARMACEUTICAL SCIENCES, VOL. 91, NO. 1, JANUARY 2002" />
+                            <Info min="0" max="1" flag="122" seq="362" ref="0" bb="32" group="112" />
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+                            <Info min="0" max="1" flag="122" seq="362" ref="0" bb="32" group="86" />
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+                          <Parameter id="rmktjjdHZEuR-HMZ02PMVg" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0375">
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+                            <Info min="0" max="1" flag="122" seq="600" ref="0" bb="32" group="92" />
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+                          <Parameter id="IEPOT01_GkSvXl_-mBnHiA" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0483">
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+                          <Parameter id="SXmaN7awz0STu_s7Rm2Whg" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0124">
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+                                  </Parameter>
+                                  <Parameter id="Y5n9FIktoU6K3vKCAZYpew" name="Start amount" description="Start amount of molecule" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" formula="EPX-QNxBZE2pcwiBNY6NfA" isDefault="1" displayUnit="µmol">
+                                    <Info flag="54" seq="1" ref="0" bb="2" group="91" />
+                                  </Parameter>
+                                  <Parameter id="7tXscNYfHUe1aOIbUATYmQ" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="_5AQF4X5mkuTWnIB24ghvw" isDefault="1" displayUnit="µmol/l">
+                                    <Info min="0" flag="18" seq="1" ref="0" bb="2" group="117" />
+                                  </Parameter>
+                                  <Parameter id="UyQUcVYG30aK0eJY9JjXkw" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="H08NhBRDpku24oIxLoSUZQ" isDefault="1">
+                                    <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                                  </Parameter>
+                                  <Parameter id="D0odwm-vIkqaQE-1gzU0zw" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="ckWLspcinE-9a1C5cITARw" isDefault="1" displayUnit="min">
+                                    <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                                  </Parameter>
+                                  <Observer id="Da-n5R5VWkeKRZ95d5xMKQ" name="Concentration in container" description="Concentration of the molecule" icon="Observer" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Enzyme, Observer" negativeValuesAllowed="1" formula="6wCmGaSt3UirOnRpXv6unA" displayUnit="µmol/l" />
+                                </Children>
+                              </MoleculeAmount>
+                              <MoleculeAmount id="IXiI7k4TAkiRJ08hJByC7A" name="Aciclovir" icon="DRUG" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" negativeValuesAllowed="0" mode="Logical" scaleDivisor="1" value="0" displayUnit="µmol">
+                                <Children>
+                                  <Parameter id="ecWpji_h4Uec176mpJ6MVA" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="_5AQF4X5mkuTWnIB24ghvw" isDefault="1" displayUnit="µmol/l">
+                                    <Info min="0" flag="18" seq="1" ref="0" bb="2" group="117" />
+                                  </Parameter>
+                                  <Parameter id="SAmIgMoohkOUw4nC8N6OHA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="D8jo9bzI1EGPnd0F8DjrhA" isDefault="1">
+                                    <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                                  </Parameter>
+                                  <Observer id="hlFeotuc4E2_YfEQbtbAAg" name="Concentration in container" description="Concentration of the molecule" icon="Observer" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" negativeValuesAllowed="1" formula="6wCmGaSt3UirOnRpXv6unA" displayUnit="µmol/l" />
+                                </Children>
+                              </MoleculeAmount>
+                            </Children>
+                          </Container>
+                        </Children>
+                      </Container>
+                    </Children>
+                  </Container>
+                  <Container id="rl0E-d8XbEKWKO8H1WmbSQ" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Observer id="nfssgsvT80OAQaSDxIFVRw" name="Interstitial Unbound" description="Interstitial Unbound" icon="Observer" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" negativeValuesAllowed="1" formula="9puGFowK4EWaB_uKiCUkZg" displayUnit="µmol/l" />
+                      <Observer id="ZGi_mQfTYkmMohE7HT1TJQ" name="Intracellular Unbound" description="Intracellular Unbound" icon="Observer" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" negativeValuesAllowed="1" formula="teOQNDXPokGxR8_kXybQ_A" displayUnit="µmol/l" />
+                      <Observer id="IJT5bUZS8kSG7iXOthT--A" name="Total Tissue (Large Intestine)" description="Mucosa and nonmucosa tissue" icon="Observer" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" negativeValuesAllowed="1" formula="BhsaGOhXBEyF1qJoy1aynQ" displayUnit="µmol/l" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Container>
+              <Container id="TrQnZFX9mUK__nY9eq3ZfA" name="Liver" description="Liver" icon="Liver" mode="Logical" containerType="Organ">
+                <Children>
+                  <Parameter id="U7_tIFKXuESd9n7inN0_Zg" name="Weight (tissue)" description="Weight of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="fliUWazsPUiRy_qjzM6EaA" isDefault="1" displayUnit="kg">
+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
+                  </Parameter>
+                  <Parameter id="fRBVmIn6eUy82C70ztA8Vg" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="SEONXx9l8UekWRlG-vCS6A" isDefault="1" displayUnit="l/min">
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+                    <Info min="0" flag="122" seq="17" ref="0" bb="32" group="27" />
+                  </Parameter>
+                  <Parameter id="HppjIQI0x0KEbCrukv131A" name="Lymph flow rate" description="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="AHUOFh7VvEGdn9pbFbN0Ng" isDefault="1" displayUnit="l/min">
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+                    <Info min="0" flag="122" seq="17" ref="0" bb="32" group="58" />
+                  </Parameter>
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+                    <Info min="0" flag="62" seq="17" ref="0" bb="32" group="127" />
+                  </Parameter>
+                  <Parameter id="hahDky7tbESb99RSw1inZg" name="Fraction intracellular" description="Fraction of intracellular space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="I-HZynBcWEaZVIcFkF3iMQ" isDefault="1">
+                    <Info min="0" max="1" flag="62" seq="54" ref="0" bb="32" group="64" />
+                  </Parameter>
+                  <Parameter id="0Xa7NH6N-kaWza2hQt__cg" name="Is liver zonated" description="Indicates if the liver is zonated" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0">
+                    <Info min="0" max="1" flag="58" seq="54" ref="0" bb="32" group="149" />
+                  </Parameter>
+                  <Parameter id="icjBPWUB-kqQ2YSyH1Qkjw" name="Fraction of periportal zone" description="Fraction of periportal zone in liver" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5" displayUnit="%">
+                    <Info min="0" max="1" flag="74" seq="55" ref="0" bb="32" group="149" />
+                  </Parameter>
+                  <Parameter id="zfe0PHca7UeZJQ42Ztdc0Q" name="Blood flow rate" description="Organ blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="y6LwIbRu9ku8erXKf1RN9w" isDefault="1" displayUnit="l/min">
+                    <ValueOrigin id="48" source="Other" description="Absolute value = specific value (i.e. value normalized to the volume of the organ) multiplied by the organ volume" />
+                    <Info min="0" flag="62" seq="142" ref="0" bb="32" group="5" />
+                  </Parameter>
+                  <Parameter id="q9_oLWf1YEyeGpMjtTiDxQ" name="Density (tissue)" description="Density of tissue" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
+                    <Info min="0" flag="38" seq="1" ref="0" bb="32" group="21" />
+                  </Parameter>
+                  <Parameter id="JWlv2Eq3rEeF9LYnPutLPg" name="EHC continuous fraction" description="Fraction of biliary secreted compound continuously entering the duodenum without being temporarily stored in the gallbladder. The fraction of hepatic bile directly entering the duodenum is species-dependent and amounts to about 30-50% in fasted humans to 100% in rats, because the rat lacks a gallbladder." icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0">
+                    <Info min="0" max="1" flag="122" seq="1" ref="0" bb="32" group="128" />
+                  </Parameter>
+                  <Parameter id="2U6vMQ9ngE6wv8sXvuQCKg" name="Fluid recirculation flow proportionality factor" description="proportionality factor linking fluid recirculation flow to lymph flow via small pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.96">
+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="27" />
+                  </Parameter>
+                  <Parameter id="BR2thiJsd0yCK5zRzO_GFA" name="Lymph flow proportionality factor" description="Proportionality factor linking lymph flow to plasma flow" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0199">
+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="58" />
+                  </Parameter>
+                  <Parameter id="q0RW-HC6_UaqA92Un00Fuw" name="Organ volume mouse" description="Organ volume mouse" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0013" displayUnit="l">
+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="65" />
+                  </Parameter>
+                  <Parameter id="uwIVo2uHkEeofLjm5VgQbw" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.75">
+                    <Info min="0.75" max="0.75" flag="54" seq="1" ref="0" bb="32" group="2" />
+                  </Parameter>
+                  <Parameter id="wnCf9MP2NUqWvWOZLfCAwA" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                    <Info min="0" max="1" flag="54" seq="1" ref="0" bb="32" group="94" />
+                  </Parameter>
+                  <Parameter id="kYHKRvd9Kk-ybMAF9wS3lA" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.8">
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" max="1" flag="122" seq="17" ref="0" bb="32" group="114" />
+                  </Parameter>
+                  <Parameter id="MYGPyhjt0EChLOqs7rJHPQ" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" icon="Parameter" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="3.88888888888889E-11" displayUnit="ml/min/N">
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="17" ref="0" bb="32" group="115" />
+                  </Parameter>
+                  <Parameter id="m5BRrLnIDE-4G0SV3kUNTQ" name="Radius (large pores)" description="Large endothelial pores radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="3.3E-07" displayUnit="µm">
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="17" ref="0" bb="32" group="55" />
+                  </Parameter>
+                  <Parameter id="-a7XUwOL9Uayy3yrXIcrtQ" name="Radius (small pores)" description="Small endothelial pores radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="9E-08" displayUnit="µm">
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="17" ref="0" bb="32" group="99" />
+                  </Parameter>
+                  <Parameter id="j7IEIsWmUE62ywoCBP4C-g" name="Fraction vascular" description="Fraction of vascular space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.17">
+                    <ValueOrigin id="40" source="Publication" description="Edginton, A.N., Schmitt, W. &amp; Willmann, S. Clin Pharmacokinet (2006) 45: 1013. https://doi.org/10.2165/00003088-200645100-00005" />
+                    <Info min="0" max="1" flag="62" seq="51" ref="0" bb="32" group="64" />
+                  </Parameter>
+                  <Parameter id="Idpdr5cOxUymjY_jyQlI2A" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.069">
+                    <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
+                    <Info min="0" max="1" flag="122" seq="51" ref="0" bb="32" group="85" />
+                  </Parameter>
+                  <Parameter id="Eto2qbSZAkKTj8SBcDHJjQ" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0348">
+                    <Info min="0" max="1" flag="122" seq="51" ref="0" bb="32" group="86" />
+                  </Parameter>
+                  <Parameter id="z4k1BwGKpkmfmx657PayvQ" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0252">
+                    <Info min="0" max="1" flag="122" seq="52" ref="0" bb="32" group="86" />
+                  </Parameter>
+                  <Parameter id="soXh_8o0_0KLWsIDJth3xg" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.184">
+                    <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
+                    <Info min="0" max="1" flag="122" seq="52" ref="0" bb="32" group="85" />
+                  </Parameter>
+                  <Parameter id="Mj9b1KN7vk26dCe0utG9BA" name="Microsomal protein mass/g tissue" description="Microsomal protein content per gram tissue" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass per tissue" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.04" displayUnit="mg/g">
+                    <Info min="0" max="1" flag="54" seq="53" ref="0" bb="32" group="59" />
+                  </Parameter>
+                  <Parameter id="spgjNDh1KkempqlK-icfiw" name="Number of cells/g tissue" description="Number of cells per gram tissue" icon="Parameter" persistable="0" isFixedValue="0" dim="Count per mass" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="139000" displayUnit="x10^6/g">
+                    <Info min="0" max="1000000" flag="54" seq="53" ref="0" bb="32" group="61" />
+                  </Parameter>
+                  <Parameter id="5zyNQBmHtUux41ljMRQrgQ" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.086">
+                    <ValueOrigin id="22" source="Publication" description="Rodgers T, Rowland M. Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J Pharm Sci. 2006 Jun;95(6):1238-57 https://doi.org/10.1002/jps.20502" />
+                    <Info min="0" max="1" flag="122" seq="53" ref="0" bb="32" group="111" />
+                  </Parameter>
+                  <Parameter id="RSDePrTgLUCQd7GCiCsn0Q" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                    <ValueOrigin id="24" source="Publication" description="POULIN P, THEIL F. Prediction of Pharmacokinetics Prior to In Vivo Studies. 1. Mechanism-Based Prediction of Volume of Distribution. JOURNAL OF PHARMACEUTICAL SCIENCES, VOL. 91, NO. 1, JANUARY 2002" />
+                    <Info min="0" max="1" flag="122" seq="53" ref="0" bb="32" group="112" />
+                  </Parameter>
+                  <Parameter id="ovA9aDmcZEOVcJ4cS2CHnQ" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.161">
+                    <ValueOrigin id="22" source="Publication" description="Rodgers T, Rowland M. Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J Pharm Sci. 2006 Jun;95(6):1238-57 https://doi.org/10.1002/jps.20502" />
+                    <Info min="0" max="1" flag="122" seq="53" ref="0" bb="32" group="113" />
+                  </Parameter>
+                  <Parameter id="6mhkdi5mS0WYxNvPcn9Dqg" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.747">
+                    <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
+                    <Info min="0" max="1" flag="122" seq="53" ref="0" bb="32" group="85" />
+                  </Parameter>
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+                    <Info min="0" max="1" flag="122" seq="53" ref="0" bb="32" group="86" />
+                  </Parameter>
+                  <Parameter id="QsMUWEMH2EeVlyQRDNy-QQ" name="Fraction interstitial" description="Fraction of interstitial space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.163">
+                    <ValueOrigin id="19" source="Publication" description="Kawai R, Lemaire M, Steimer JL, Bruelisauer A, Niederberger W, Rowland M. Physiologically based pharmacokinetic study on a cyclosporin derivative, SDZ IMM 125. J Pharmacokinet Biopharm. 1994 Oct;22(5):327-65." />
+                    <Info min="0" max="1" flag="62" seq="57" ref="0" bb="32" group="64" />
+                  </Parameter>
+                  <Parameter id="q-iLGGgPDUics3akXo2nrA" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0135">
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+                    <Info min="0" max="1" flag="122" seq="85" ref="0" bb="32" group="92" />
+                  </Parameter>
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+                    <Info min="0" max="1" flag="122" seq="85" ref="0" bb="32" group="95" />
+                  </Parameter>
+                  <Parameter id="v0PHHKX4dkWqojFZ-BKZXQ" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0238">
+                    <ValueOrigin id="22" source="Publication" description="Rodgers T, Rowland M. Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J Pharm Sci. 2006 Jun;95(6):1238-57 https://doi.org/10.1002/jps.20502" />
+                    <Info min="0" max="1" flag="122" seq="86" ref="0" bb="32" group="92" />
+                  </Parameter>
+                  <Parameter id="yYRP5BO1-USmOrkQsh1-Rw" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0472">
+                    <Info min="0" max="1" flag="122" seq="86" ref="0" bb="32" group="95" />
+                  </Parameter>
+                  <Parameter id="PRf4yPXtU0KK7nZM0gxjqw" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.161">
+                    <ValueOrigin id="21" source="Publication" description="Rodgers T, Leahy D, Rowland M. Physiologically based pharmacokinetic modeling 1: predicting the tissue distribution of moderate-to-strong bases. J Pharm Sci. 2005 Jun;94(6):1259-76. https://doi.org/10.1002/jps.20322" />
+                    <Info min="0" max="1" flag="122" seq="87" ref="0" bb="32" group="92" />
+                  </Parameter>
+                  <Parameter id="B45GhPjmr02QMuhAzxDLfg" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.21">
+                    <Info min="0" max="1" flag="122" seq="87" ref="0" bb="32" group="95" />
+                  </Parameter>
+                  <Parameter id="IhGSIC2fH0ioBcgOGYoRVw" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.481">
+                    <ValueOrigin id="22" source="Publication" description="Rodgers T, Rowland M. Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J Pharm Sci. 2006 Jun;95(6):1238-57 https://doi.org/10.1002/jps.20502" />
+                    <Info min="0" max="1" flag="122" seq="88" ref="0" bb="32" group="92" />
+                  </Parameter>
+                  <Parameter id="ijFVLwE1fkCLC7Ohj0SbbQ" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.68">
+                    <Info min="0" max="1" flag="122" seq="88" ref="0" bb="32" group="95" />
+                  </Parameter>
+                  <Parameter id="-2zRuER9Z0ePJfvJ5FnOyA" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="4.56">
+                    <ValueOrigin id="21" source="Publication" description="Rodgers T, Leahy D, Rowland M. Physiologically based pharmacokinetic modeling 1: predicting the tissue distribution of moderate-to-strong bases. J Pharm Sci. 2005 Jun;94(6):1259-76. https://doi.org/10.1002/jps.20322" />
+                    <Info min="0" max="1000" flag="122" seq="89" ref="0" bb="32" group="92" />
+                  </Parameter>
+                  <Parameter id="4dW50gOpAEmUv5PmJJOZ8Q" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0088">
+                    <Info min="0" max="1" flag="122" seq="89" ref="0" bb="32" group="95" />
+                  </Parameter>
+                  <DistributedParameter id="QYRXRQwkE0-8R9nDEHApUA" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="X24b_af9t06rieo4L7lDRg" mode="Logical" isDefault="1" displayUnit="l">
+                    <Children>
+                      <Parameter id="zike1ppQqUmfflmc27SNWg" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.513760933563919">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="65" />
+                      </Parameter>
+                      <Parameter id="45CdK0XfZEqM47sKppwvbA" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="2.3578466712" displayUnit="l">
+                        <Info min="0" flag="34" seq="1" ref="0" bb="32" group="65" />
+                      </Parameter>
+                      <Parameter id="Z9xPILCzmk2rM4LCamloRQ" name="Deviation" description="Standard deviation of Normal distribution" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.551406891692952" displayUnit="l">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="65" />
+                      </Parameter>
+                    </Children>
+                    <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
+                    <Info min="0" flag="106" seq="9" ref="0" bb="32" group="65" />
+                  </DistributedParameter>
+                  <DistributedParameter id="BXdAYMwlb0GrR4hobBS2yQ" name="Specific blood flow rate" description="Blood flow rate normalized to the organ volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" formula="06V3k9vwE0Cqbm4K-yWHxw" mode="Logical" isDefault="1" displayUnit="ml/min/100g organ">
+                    <Children>
+                      <Parameter id="R1VUQdsVoUiHMdYPirEaDQ" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="5" />
+                      </Parameter>
+                      <Parameter id="XBCJGftw_ESpTBugm17vvg" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.1794" displayUnit="ml/min/100g organ">
+                        <Info min="0" flag="50" seq="1" ref="0" bb="32" group="5" />
+                      </Parameter>
+                      <Parameter id="HufvP0_2FUysOTZZZQAMnw" name="Deviation" description="Standard deviation of Normal distribution" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.00897" displayUnit="ml/min/100g organ">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="5" />
+                      </Parameter>
+                    </Children>
+                    <ValueOrigin id="40" source="Publication" description="Edginton, A.N., Schmitt, W. &amp; Willmann, S. Clin Pharmacokinet (2006) 45: 1013. https://doi.org/10.2165/00003088-200645100-00005" />
+                    <Info min="0" flag="122" seq="141" ref="0" bb="32" group="5" />
+                  </DistributedParameter>
+                  <Container id="ITMItQodOkSEFW2tzkh0ng" name="Periportal" description="Liver Periportal" icon="Periportal" mode="Logical" containerType="Compartment">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="j4LDCMTVCk6hHACQGOKeCg" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="m5LVQd4-kECi2gTqfPKbdg" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0.75" max="0.75" flag="54" seq="1" ref="0" bb="32" group="2" />
+                      </Parameter>
+                      <Parameter id="GwaBqxl2aUKlg2pSt0TgpQ" name="Density (tissue)" description="Density of tissue" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" formula="dvU3uL0rWkSwMA1eJfUIUQ" isDefault="1" displayUnit="g/cm³">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" flag="38" seq="1" ref="0" bb="32" group="21" />
+                      </Parameter>
+                      <Parameter id="brKqNyxvhEmv8VUWupks3w" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BX3RfW9W6Eu5LlHdhUkdbg" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="1" ref="0" bb="32" group="94" />
+                      </Parameter>
+                      <Parameter id="lfrmnSCVMECMLD15IsrfXA" name="Weight (tissue)" description="Weight of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="fliUWazsPUiRy_qjzM6EaA" isDefault="1" displayUnit="kg">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
+                      </Parameter>
+                      <Parameter id="KJoDvvXUBUqE1oC_YwhCPw" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="mWm0tuOo_EiyfmV9073mNw" isDefault="1" displayUnit="l">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" flag="62" seq="9" ref="0" bb="32" group="65" />
+                      </Parameter>
+                      <Parameter id="2bv81lwCbEG8S2fx86X2PA" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="tle4l4T7_U2fkncZOMTZRg" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="17" ref="0" bb="32" group="114" />
+                      </Parameter>
+                      <Parameter id="kuMjfCj1tUaKr9pdhDUsRw" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="_JuzmUDyv0mNhV_l5rT27w" isDefault="1" displayUnit="l/min">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                        <Info min="0" flag="62" seq="17" ref="0" bb="32" group="27" />
+                      </Parameter>
+                      <Parameter id="eqcCgMqhUEmbhw7Mcm4Aew" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" icon="Parameter" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" negativeValuesAllowed="1" formula="Bu37S03Z60K0zW0gSifEbg" isDefault="1" displayUnit="ml/min/N">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" flag="54" seq="17" ref="0" bb="32" group="115" />
+                      </Parameter>
+                      <Parameter id="ny-21hYybU6a61AUXZzS5w" name="Lymph flow rate" description="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="A6Tqa6FSVkSsUZk1VD1YPg" isDefault="1" displayUnit="l/min">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                        <Info min="0" flag="62" seq="17" ref="0" bb="32" group="58" />
+                      </Parameter>
+                      <Parameter id="xBhVyyp9fkyKygqRiklLzg" name="Radius (large pores)" description="Large endothelial pores radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="0f4MLpLmIUOm8oNVv2XY9A" isDefault="1" displayUnit="µm">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" flag="54" seq="17" ref="0" bb="32" group="55" />
+                      </Parameter>
+                      <Parameter id="IzGOvDOXfkqrHBPIcLd0JQ" name="Radius (small pores)" description="Small endothelial pores radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="-aNNADxsLUmgc6fv7y1lqw" isDefault="1" displayUnit="µm">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" flag="54" seq="17" ref="0" bb="32" group="99" />
+                      </Parameter>
+                      <Parameter id="Juxa4t3l3EOumo3p5TVZ-w" name="Volume (endothelium)" description="Volume of  vascular endothelium" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="xJQPD2GV1ESIJ3tKBrmSsA" isDefault="1" displayUnit="l">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" flag="62" seq="17" ref="0" bb="32" group="127" />
+                      </Parameter>
+                      <Parameter id="zMk7jsd2hkCvUtelOfMx-A" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="s6ty8I0nRUSgYjCwliCykQ" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="51" ref="0" bb="32" group="85" />
+                      </Parameter>
+                      <Parameter id="A3GSYG6H7EO6QfHrZ99ipw" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="OfxeEvyG60KCNu_gCweB9g" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="51" ref="0" bb="32" group="86" />
+                      </Parameter>
+                      <Parameter id="uJ6RKEm6bEO7JmRbGO1AvA" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="hqQzm0pMAEyGsk6viznbtQ" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="52" ref="0" bb="32" group="86" />
+                      </Parameter>
+                      <Parameter id="Xyewhr06TUCyEKCpaQFFXQ" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="jRHKfL-nkUenUBbLdg1zFA" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="52" ref="0" bb="32" group="85" />
+                      </Parameter>
+                      <Parameter id="ONxYTlzNAku1syQ8jTnyTA" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Zb6bH_Rba0K8z6NUibsNnw" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="53" ref="0" bb="32" group="111" />
+                      </Parameter>
+                      <Parameter id="GXyLYroe_kGgak03X1k9Uw" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="-xVcJOxQmkaZuLmdhqcD3g" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="53" ref="0" bb="32" group="112" />
+                      </Parameter>
+                      <Parameter id="UPamKq7A3EuWidQ9O0MXCw" name="Fraction vascular" description="Fraction of vascular space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="oDAfPHcU8E2WGZ54zlNdVQ" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="53" ref="0" bb="32" group="64" />
+                      </Parameter>
+                      <Parameter id="rzBKTB-ffEKOzfvXnWWkNQ" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="t7x3zoGbYEO7srHBk2_Wpw" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="53" ref="0" bb="32" group="113" />
+                      </Parameter>
+                      <Parameter id="qX63IYHzzkSNqHK5Xh5Xyg" name="Microsomal protein mass/g tissue" description="Microsomal protein content per gram tissue" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass per tissue" quantityType="Parameter" negativeValuesAllowed="1" formula="Z2zcVjH1Sk6LGXVdjXG_Aw" isDefault="1" displayUnit="mg/g">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="53" ref="0" bb="32" group="59" />
+                      </Parameter>
+                      <Parameter id="kZ6cQjfnLUicIqbjb-PA3A" name="Number of cells/g tissue" description="Number of cells per gram tissue" icon="Parameter" persistable="0" isFixedValue="0" dim="Count per mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Kf4Crs4YYUS75tSUzrErXA" isDefault="1" displayUnit="x10^6/g">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1000000" flag="54" seq="53" ref="0" bb="32" group="61" />
+                      </Parameter>
+                      <Parameter id="859RQS8x4kK35bntFMdcEQ" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="fli89AMhvUKKiJ-Q6Zb6xQ" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="53" ref="0" bb="32" group="85" />
+                      </Parameter>
+                      <Parameter id="h8QQNFG3SUKyIE0EZBfwqg" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="KUkaz6U9Y0y0jwWImtUAXw" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="53" ref="0" bb="32" group="86" />
+                      </Parameter>
+                      <Parameter id="MKqaX_LZWkSIxXE-7oYI8Q" name="Fraction intracellular" description="Fraction of intracellular space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_X6z2CBxuUKLwMTmhQBMHQ" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="56" ref="0" bb="32" group="64" />
+                      </Parameter>
+                      <Parameter id="bQ3jSPwqd0qz1hOQ2WO2FA" name="Fraction interstitial" description="Fraction of interstitial space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="SNRSrFl1606Ss_buWaKS8A" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="59" ref="0" bb="32" group="64" />
+                      </Parameter>
+                      <Parameter id="w3QLUIhwGkCaxQ6lGxrGVg" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="GWnGJ38GkUeCAqDlAApeyw" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="85" ref="0" bb="32" group="92" />
+                      </Parameter>
+                      <Parameter id="6gFH70VET0K2i6j8nhJmbg" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="GY06FGQvUE-1dyYU2B0v9A" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="85" ref="0" bb="32" group="95" />
+                      </Parameter>
+                      <Parameter id="jV8YIHbJDUemO94oYrAP4A" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="giwCKQOfzkCov3cyGg_x-Q" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="86" ref="0" bb="32" group="92" />
+                      </Parameter>
+                      <Parameter id="ax-VeFNM-0uXrmf8bdLWQg" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="FlfBM27PekCX_06nfjdN_Q" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="86" ref="0" bb="32" group="95" />
+                      </Parameter>
+                      <Parameter id="on5l7A7q9U6AOBiIYwvFZQ" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="oGvtJpxdDUCTAP3qKnWD9g" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="87" ref="0" bb="32" group="92" />
+                      </Parameter>
+                      <Parameter id="vf1FFV2R502_N1I8WncqSg" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="qwINYy1NV0ynSb2tSt0djg" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="87" ref="0" bb="32" group="95" />
+                      </Parameter>
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+                                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="91" />
+                              </Parameter>
+                              <Parameter id="NNiKiRsPvEia74TNBBrRBw" name="Relative expression" description="Relative expression" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0">
+                                <Info min="0" flag="60" seq="1" ref="0" bb="32" group="91" />
+                              </Parameter>
+                              <Parameter id="6e0dhtI43EelvGL-xOdIGg" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0">
+                                <Info min="0" flag="58" seq="1" ref="0" bb="32" group="91" />
+                              </Parameter>
+                              <Parameter id="grYqVgZgckKpOZG1bX17LA" name="Relative expression out." description="Relative Expression that will be used in the simulation" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="fbRCNZOks0i0JlaOaYnbvg" isDefault="1">
+                                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="91" />
+                              </Parameter>
+                              <Parameter id="Sry7--NDKEuLc1ZVc4brAA" name="Start amount" description="Start amount of molecule" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" formula="EPX-QNxBZE2pcwiBNY6NfA" isDefault="1" displayUnit="µmol">
+                                <Info flag="54" seq="1" ref="0" bb="2" group="91" />
+                              </Parameter>
+                              <Parameter id="mIXBjvodSEGa-JSSWRWjtQ" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="_5AQF4X5mkuTWnIB24ghvw" isDefault="1" displayUnit="µmol/l">
+                                <Info min="0" flag="18" seq="1" ref="0" bb="2" group="117" />
+                              </Parameter>
+                              <Parameter id="GsRq-gLazUuOXFL8B8rkgg" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ahoSJqRfG0-80IqU2UoVDQ" isDefault="1">
+                                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                              </Parameter>
+                              <Parameter id="t4OetFzOY0ibLLjWeDiMaA" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="Uyixq8xt9kq0xZWzZrx4rg" isDefault="1" displayUnit="min">
+                                <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                              </Parameter>
+                              <Observer id="mheIplyt1Ea7X5nGExRdcA" name="Concentration in container" description="Concentration of the molecule" icon="Observer" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Enzyme, Observer" negativeValuesAllowed="1" formula="6wCmGaSt3UirOnRpXv6unA" displayUnit="µmol/l" />
+                            </Children>
+                          </MoleculeAmount>
+                          <MoleculeAmount id="iguGT0JRWkCNjr7lnacULQ" name="Aciclovir" icon="DRUG" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" negativeValuesAllowed="0" mode="Logical" scaleDivisor="1" value="0" displayUnit="µmol">
+                            <Children>
+                              <Parameter id="cQbD0csk30OS8_vuQmZNsw" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="_5AQF4X5mkuTWnIB24ghvw" isDefault="1" displayUnit="µmol/l">
+                                <Info min="0" flag="18" seq="1" ref="0" bb="2" group="117" />
+                              </Parameter>
+                              <Parameter id="sYT4nKh3PUi-cNsW0WxsIA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="p7L-Z4kf5U6yLqJ1UXYMFQ" isDefault="1">
+                                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                              </Parameter>
+                              <Observer id="uCxT_Qi2ukqWbDw-1nVO7Q" name="Concentration in container" description="Concentration of the molecule" icon="Observer" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" negativeValuesAllowed="1" formula="6wCmGaSt3UirOnRpXv6unA" displayUnit="µmol/l" />
+                            </Children>
+                          </MoleculeAmount>
+                        </Children>
+                      </Container>
+                      <Container id="NfqTCN13W0ClVNQdXtCG7g" name="Aciclovir" mode="Logical" containerType="Molecule">
+                        <Children>
+                          <Observer id="IdDNKOZ1y0OboU7JTEjwJQ" name="Interstitial Unbound" description="Interstitial Unbound" icon="Observer" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" negativeValuesAllowed="1" formula="9puGFowK4EWaB_uKiCUkZg" displayUnit="µmol/l" />
+                          <Observer id="2tmabniKpE-Vvr3GRn1vGA" name="Intracellular Unbound" description="Intracellular Unbound" icon="Observer" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" negativeValuesAllowed="1" formula="teOQNDXPokGxR8_kXybQ_A" displayUnit="µmol/l" />
+                          <Observer id="L4OdMpOVIUCl05FaRr096g" name="Tissue" description="Tissue" icon="Observer" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" negativeValuesAllowed="1" formula="vXvnx5OPgEOFlJ6Oq1kSGw" displayUnit="µmol/l" />
+                        </Children>
+                      </Container>
+                    </Children>
+                  </Container>
+                  <Container id="IukXWENNY0yhlUltsG53bA" name="Pericentral" description="Liver Pericentral" icon="Pericentral" mode="Logical" containerType="Compartment">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="f9ILY5OKgkmT88SQ52zEAg" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="m5LVQd4-kECi2gTqfPKbdg" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0.75" max="0.75" flag="54" seq="1" ref="0" bb="32" group="2" />
+                      </Parameter>
+                      <Parameter id="tVIyRbLUTECerEuPEx039A" name="Density (tissue)" description="Density of tissue" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" formula="dvU3uL0rWkSwMA1eJfUIUQ" isDefault="1" displayUnit="g/cm³">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" flag="38" seq="1" ref="0" bb="32" group="21" />
+                      </Parameter>
+                      <Parameter id="qi-vCuH7ekK6xWrTUy1ivA" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BX3RfW9W6Eu5LlHdhUkdbg" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="1" ref="0" bb="32" group="94" />
+                      </Parameter>
+                      <Parameter id="qfnNoWNijk6wIrz47y910Q" name="Weight (tissue)" description="Weight of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="fliUWazsPUiRy_qjzM6EaA" isDefault="1" displayUnit="kg">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" flag="54" seq="1" ref="0" bb="32" group="136" />
+                      </Parameter>
+                      <Parameter id="RGgI3sXNWEWWHXkyPbJgMg" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="UnJ9GSpKOkydcRR_oV6sXw" isDefault="1" displayUnit="l">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" flag="62" seq="10" ref="0" bb="32" group="65" />
+                      </Parameter>
+                      <Parameter id="XwGPnaylWkKYvcQ0iWPTmg" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="tle4l4T7_U2fkncZOMTZRg" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="17" ref="0" bb="32" group="114" />
+                      </Parameter>
+                      <Parameter id="zyXjsz0Jv06q82FRnZdR9w" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" icon="Parameter" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" negativeValuesAllowed="1" formula="Bu37S03Z60K0zW0gSifEbg" isDefault="1" displayUnit="ml/min/N">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" flag="54" seq="17" ref="0" bb="32" group="115" />
+                      </Parameter>
+                      <Parameter id="Y9Vs_lsY_U-jfuIJ_oFhiw" name="Radius (large pores)" description="Large endothelial pores radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="0f4MLpLmIUOm8oNVv2XY9A" isDefault="1" displayUnit="µm">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" flag="54" seq="17" ref="0" bb="32" group="55" />
+                      </Parameter>
+                      <Parameter id="1RSSZsIGKUakltDtytC4vQ" name="Radius (small pores)" description="Small endothelial pores radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="-aNNADxsLUmgc6fv7y1lqw" isDefault="1" displayUnit="µm">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" flag="54" seq="17" ref="0" bb="32" group="99" />
+                      </Parameter>
+                      <Parameter id="EkUgeo1kdE6rTc4sDUg_ow" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="jTjiCRmWoU24QH0Uu5u-gg" isDefault="1" displayUnit="l/min">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                        <Info min="0" flag="62" seq="18" ref="0" bb="32" group="27" />
+                      </Parameter>
+                      <Parameter id="bayutfyzokmPx20sGyXgzw" name="Lymph flow rate" description="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="4T5QLR2g_EifaY7CPeWMJw" isDefault="1" displayUnit="l/min">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                        <Info min="0" flag="62" seq="18" ref="0" bb="32" group="58" />
+                      </Parameter>
+                      <Parameter id="t91_GMDdpU2vA3QpqjWgvQ" name="Volume (endothelium)" description="Volume of  vascular endothelium" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="IgNLC5V4LEyib2eq11a_Tg" isDefault="1" displayUnit="l">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" flag="62" seq="18" ref="0" bb="32" group="127" />
+                      </Parameter>
+                      <Parameter id="FZ0ipG5iXEqgTyUtpSSpyQ" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="s6ty8I0nRUSgYjCwliCykQ" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="51" ref="0" bb="32" group="85" />
+                      </Parameter>
+                      <Parameter id="cDLS5T47akuBSec1or4RzQ" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="OfxeEvyG60KCNu_gCweB9g" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="51" ref="0" bb="32" group="86" />
+                      </Parameter>
+                      <Parameter id="gFTbOmHs8kKQiW_n4h38tA" name="Fraction vascular" description="Fraction of vascular space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="oDAfPHcU8E2WGZ54zlNdVQ" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="52" ref="0" bb="32" group="64" />
+                      </Parameter>
+                      <Parameter id="uhp0UnM8WkKf4PLVCqEplA" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="hqQzm0pMAEyGsk6viznbtQ" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="52" ref="0" bb="32" group="86" />
+                      </Parameter>
+                      <Parameter id="mxWQxR0WhUaouMOwUE7Dxg" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="jRHKfL-nkUenUBbLdg1zFA" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="52" ref="0" bb="32" group="85" />
+                      </Parameter>
+                      <Parameter id="wte5k4QONEWA3tpxYT5IwQ" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Zb6bH_Rba0K8z6NUibsNnw" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="53" ref="0" bb="32" group="111" />
+                      </Parameter>
+                      <Parameter id="2mnlpEkiukmyihMiVbitmQ" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="-xVcJOxQmkaZuLmdhqcD3g" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="53" ref="0" bb="32" group="112" />
+                      </Parameter>
+                      <Parameter id="OaXFt5teAUG2zmaVOF4vgg" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="t7x3zoGbYEO7srHBk2_Wpw" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="53" ref="0" bb="32" group="113" />
+                      </Parameter>
+                      <Parameter id="mDD65peLhUaFqQGKuQhmug" name="Microsomal protein mass/g tissue" description="Microsomal protein content per gram tissue" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass per tissue" quantityType="Parameter" negativeValuesAllowed="1" formula="Z2zcVjH1Sk6LGXVdjXG_Aw" isDefault="1" displayUnit="mg/g">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="53" ref="0" bb="32" group="59" />
+                      </Parameter>
+                      <Parameter id="d6C0L1J_kU6_Ybh0EsCPTg" name="Number of cells/g tissue" description="Number of cells per gram tissue" icon="Parameter" persistable="0" isFixedValue="0" dim="Count per mass" quantityType="Parameter" negativeValuesAllowed="1" formula="Kf4Crs4YYUS75tSUzrErXA" isDefault="1" displayUnit="x10^6/g">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1000000" flag="54" seq="53" ref="0" bb="32" group="61" />
+                      </Parameter>
+                      <Parameter id="74jV6E4_7EGedawrjD20ug" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="fli89AMhvUKKiJ-Q6Zb6xQ" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="53" ref="0" bb="32" group="85" />
+                      </Parameter>
+                      <Parameter id="yryptohmQ0i9nisKmKQXgg" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="KUkaz6U9Y0y0jwWImtUAXw" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="53" ref="0" bb="32" group="86" />
+                      </Parameter>
+                      <Parameter id="USS2jRZx7kWZKawNmv-Wog" name="Fraction intracellular" description="Fraction of intracellular space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_X6z2CBxuUKLwMTmhQBMHQ" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="55" ref="0" bb="32" group="64" />
+                      </Parameter>
+                      <Parameter id="L3se6ZjicEyTDXOKCXwxiA" name="Fraction interstitial" description="Fraction of interstitial space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="SNRSrFl1606Ss_buWaKS8A" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="58" ref="0" bb="32" group="64" />
+                      </Parameter>
+                      <Parameter id="dZXYCDbx6kOYquhSZ5pkIQ" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="GWnGJ38GkUeCAqDlAApeyw" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="85" ref="0" bb="32" group="92" />
+                      </Parameter>
+                      <Parameter id="RLUsBIMV2k6V_-FovK4YTA" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="GY06FGQvUE-1dyYU2B0v9A" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="85" ref="0" bb="32" group="95" />
+                      </Parameter>
+                      <Parameter id="9b5yAZkYL0iVHi33ICQhdA" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="giwCKQOfzkCov3cyGg_x-Q" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="86" ref="0" bb="32" group="92" />
+                      </Parameter>
+                      <Parameter id="d9NySayyMU-q0fRd_J_pwA" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="FlfBM27PekCX_06nfjdN_Q" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="86" ref="0" bb="32" group="95" />
+                      </Parameter>
+                      <Parameter id="82j3Xhnos0e7YEZ3aDxHfg" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="oGvtJpxdDUCTAP3qKnWD9g" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="87" ref="0" bb="32" group="92" />
+                      </Parameter>
+                      <Parameter id="JVIHIhizpkmuy2XYpxaD8Q" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="qwINYy1NV0ynSb2tSt0djg" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="87" ref="0" bb="32" group="95" />
+                      </Parameter>
+                      <Parameter id="SqVa1QWIOk-g5qcJsL0jTw" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="EZH27OUICU6Y6F3lduLKaA" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="88" ref="0" bb="32" group="92" />
+                      </Parameter>
+                      <Parameter id="kXK2Ev1Mfk6U1qStt--tQA" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="EN4qmnZE-UqTcSduTqbjlA" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="88" ref="0" bb="32" group="95" />
+                      </Parameter>
+                      <Parameter id="xd-LAgibv0yI8TwtET8q5g" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="pqBCZamq8061HIUcLXt--w" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1000" flag="54" seq="89" ref="0" bb="32" group="92" />
+                      </Parameter>
+                      <Parameter id="TNTqyfgK0EiEf2eDSA98kw" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Ei4RgOHJU0CiRVzeZE0elw" isDefault="1">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" max="1" flag="54" seq="89" ref="0" bb="32" group="95" />
+                      </Parameter>
+                      <Parameter id="zJBJeC6Rr0ij1WkkSLJiSQ" name="Specific blood flow rate" description="Blood flow rate normalized to the organ volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" formula="mF5cU5PkKEKg3eiAlD72rA" isDefault="1" displayUnit="ml/min/100g organ">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" flag="54" seq="141" ref="0" bb="32" group="5" />
+                      </Parameter>
+                      <Parameter id="Plgho3m5IUizNbqYtZjM0w" name="Blood flow rate" description="Organ blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="ASnXyPmqc0-_7HM37L8jiQ" isDefault="1" displayUnit="l/min">
+                        <Tags>
+                          <Tag value="TissueOrgan" />
+                        </Tags>
+                        <Info min="0" flag="54" seq="142" ref="0" bb="32" group="5" />
+                      </Parameter>
+                      <Container id="nMmv0kFQ_kWYQzIhWEinuQ" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
+                        <Tags>
+                          <Tag value="Liver" />
+                          <Tag value="Pericentral" />
+                        </Tags>
+                        <Children>
+                          <Parameter id="XQO2T4b95Eicl_WGzlzdRg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="WiDWMA7xi02WdVvl1Rjr0g" isDefault="1" displayUnit="l">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Parameter id="Aq2P3YnmqUqpKtpwGjVQqQ" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="yYX4DjDwkEOGUvd-DF06pA" isDefault="1" displayUnit="l">
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+                            <Children>
+                              <Parameter id="NUlweAPD60qbhM2xOCPZ9A" name="Degradation coefficient" description="First order turnover rate constant of the enzyme" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="c2fNMePAyki4XPdR-AEHaQ" isDefault="1" displayUnit="1/min">
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+                              <Parameter id="YYDfq7FtH0S2kTRxGQLgZQ" name="Relative expression" description="Relative expression" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="fqrxyq94VkWMTLJeRjjhEQ" isDefault="1">
+                                <Info min="0" flag="60" seq="1" ref="0" bb="2" group="91" />
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+                              <Parameter id="hFmXe1Br70Oj2r7wVxW7zQ" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="YQ_SIzoIak2o9B3xCbLazA" isDefault="1">
+                                <Info min="0" flag="58" seq="1" ref="0" bb="2" group="91" />
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+                              <Parameter id="j4k_4e7erEeFLdZ9JBndcg" name="Relative expression out." description="Relative Expression that will be used in the simulation" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="fbRCNZOks0i0JlaOaYnbvg" isDefault="1">
+                                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="91" />
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+                              <Parameter id="pWx6n-J7L0apIyZpAIuYeQ" name="Start amount" description="Start amount of molecule" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" formula="EPX-QNxBZE2pcwiBNY6NfA" isDefault="1" displayUnit="µmol">
+                                <Info flag="54" seq="1" ref="0" bb="2" group="91" />
+                              </Parameter>
+                              <Parameter id="VnA5-9Mjm0y-MYnM-dM1uw" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="_5AQF4X5mkuTWnIB24ghvw" isDefault="1" displayUnit="µmol/l">
+                                <Info min="0" flag="18" seq="1" ref="0" bb="2" group="117" />
+                              </Parameter>
+                              <Parameter id="DJoUUPX9wEK35QykFvTrNA" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="JZi8fI56vUmQnKMGTWM7Yw" isDefault="1">
+                                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
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+                              <Parameter id="oaU3wLHGqE-6LwpZt8keiQ" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="lucnALB-dk2S_NDvRO6m0w" isDefault="1" displayUnit="min">
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+                              <Observer id="aKx1-iawO0y9kexd9J8thw" name="Concentration in container" description="Concentration of the molecule" icon="Observer" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Enzyme, Observer" negativeValuesAllowed="1" formula="6wCmGaSt3UirOnRpXv6unA" displayUnit="µmol/l" />
+                            </Children>
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+                          <MoleculeAmount id="as_T4ZrleUmCMyQ2xi_8gQ" name="Aciclovir" icon="DRUG" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" negativeValuesAllowed="0" mode="Logical" scaleDivisor="1" value="0" displayUnit="µmol">
+                            <Children>
+                              <Parameter id="nPdYoLDp60C7lPA-zF6LXw" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="_5AQF4X5mkuTWnIB24ghvw" isDefault="1" displayUnit="µmol/l">
+                                <Info min="0" flag="18" seq="1" ref="0" bb="2" group="117" />
+                              </Parameter>
+                              <Parameter id="-2guOxQqpE6Ys4NYCZr_Hw" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_BQxeA_VOU20Zt1idRX35w" isDefault="1">
+                                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
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+                              <Observer id="Tt3dpwLQgEWvH8P1xOrIWQ" name="Concentration in container" description="Concentration of the molecule" icon="Observer" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" negativeValuesAllowed="1" formula="6wCmGaSt3UirOnRpXv6unA" displayUnit="µmol/l" />
+                            </Children>
+                          </MoleculeAmount>
+                        </Children>
+                      </Container>
+                      <Container id="hdm7_1fsfUmYOyYmPmNQ-A" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
+                        <Tags>
+                          <Tag value="Liver" />
+                          <Tag value="Pericentral" />
+                        </Tags>
+                        <Children>
+                          <Parameter id="tuRadc2pbUepYZTQruWw6A" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="WiDWMA7xi02WdVvl1Rjr0g" isDefault="1" displayUnit="l">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
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+                          <Parameter id="gTfWGUo7KEaFlBKDJM7i7g" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="H_SN9-_mbUGRPDaFmFf1dQ" isDefault="1" displayUnit="l">
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+                                <Info min="0" flag="60" seq="1" ref="0" bb="2" group="91" />
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+                              <Parameter id="bpIb3BgjME2y6UiUTGfirA" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="xTktpLRZC0e7-rlZenlyLg" isDefault="1">
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+                              <Parameter id="EPD4b3JZdUeVWPfk7HRlDw" name="Relative expression out." description="Relative Expression that will be used in the simulation" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="fbRCNZOks0i0JlaOaYnbvg" isDefault="1">
+                                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="91" />
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+                              <Parameter id="tyvnEtmRu0iTqfGWelWuPw" name="Start amount" description="Start amount of molecule" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" formula="EPX-QNxBZE2pcwiBNY6NfA" isDefault="1" displayUnit="µmol">
+                                <Info flag="54" seq="1" ref="0" bb="2" group="91" />
+                              </Parameter>
+                              <Parameter id="sc_Gj7eLdka0FP0bab2ccg" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="_5AQF4X5mkuTWnIB24ghvw" isDefault="1" displayUnit="µmol/l">
+                                <Info min="0" flag="18" seq="1" ref="0" bb="2" group="117" />
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+                              <Parameter id="Tb0CUHpZz0elww5KSs5gRQ" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="lotgH6HuC0e2co_MeaoAsw" isDefault="1">
+                                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                              </Parameter>
+                              <Parameter id="iY7kQN8LW0-_hy0mU9jkLQ" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="ygWmZGDtqU2srf5kYckVFQ" isDefault="1" displayUnit="min">
+                                <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
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+                            </Children>
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+                              <Parameter id="1j1gKKevEkyqzDNPLlzMqQ" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="_5AQF4X5mkuTWnIB24ghvw" isDefault="1" displayUnit="µmol/l">
+                                <Info min="0" flag="18" seq="1" ref="0" bb="2" group="117" />
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+                              <Parameter id="p-QZsx2spEKsYIIQ0pgQZg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="KTx8Kq7NSEe9ryPm7ngMsA" isDefault="1">
+                                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
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+                              <Observer id="tatlfwAwjkWIsobmCyu4eA" name="Concentration in container" description="Concentration of the molecule" icon="Observer" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" negativeValuesAllowed="1" formula="6wCmGaSt3UirOnRpXv6unA" displayUnit="µmol/l" />
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+                        <Tags>
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+                          <Parameter id="0JvDO-X6Q0GE-u3nVIwMBg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="WiDWMA7xi02WdVvl1Rjr0g" isDefault="1" displayUnit="l">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
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+                              <Parameter id="JIV0VjFWlUyp0xubPqw9zQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Um5XPoWaGEyqTT15kQVVbA" isDefault="1">
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+                                <Info min="0" flag="60" seq="1" ref="0" bb="32" group="91" />
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+                              <Parameter id="lOy3zXFyO0CmS06QSAD-uQ" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
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+                  <Parameter id="TcZrV5IJL0qHpMClgZcWfw" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.009">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="55" ref="0" bb="32" group="86" />
+                  </Parameter>
+                  <Parameter id="BbVjEmH8fkmFCuGvo9aiDg" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.183">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
+                    <Info min="0" max="1" flag="122" seq="55" ref="0" bb="32" group="85" />
+                  </Parameter>
+                  <Parameter id="uZJsM6Q9IEOmKeKqX0fMqg" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.212">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="22" source="Publication" description="Rodgers T, Rowland M. Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J Pharm Sci. 2006 Jun;95(6):1238-57 https://doi.org/10.1002/jps.20502" />
+                    <Info min="0" max="1" flag="122" seq="56" ref="0" bb="32" group="111" />
+                  </Parameter>
+                  <Parameter id="Ul4giQqEKUe0-6nRmPVuhw" name="Albumin ratio (tissue/plasma)-PT" description="Ratio of albumin concentration found in tissue vs. plasma used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="24" source="Publication" description="POULIN P, THEIL F. Prediction of Pharmacokinetics Prior to In Vivo Studies. 1. Mechanism-Based Prediction of Volume of Distribution. JOURNAL OF PHARMACEUTICAL SCIENCES, VOL. 91, NO. 1, JANUARY 2002" />
+                    <Info min="0" max="1" flag="122" seq="56" ref="0" bb="32" group="112" />
+                  </Parameter>
+                  <Parameter id="jFsRpIBw20mmWtEs2rwfWA" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.168">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="22" source="Publication" description="Rodgers T, Rowland M. Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J Pharm Sci. 2006 Jun;95(6):1238-57 https://doi.org/10.1002/jps.20502" />
+                    <Info min="0" max="1" flag="122" seq="56" ref="0" bb="32" group="113" />
+                  </Parameter>
+                  <Parameter id="cm8EgV7we0SIIa5TP6TeuQ" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.807">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
+                    <Info min="0" max="1" flag="122" seq="56" ref="0" bb="32" group="85" />
+                  </Parameter>
+                  <Parameter id="U15RwOjGA0iMK_PVwievXA" name="Vf (water)-PT" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.811">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="56" ref="0" bb="32" group="86" />
+                  </Parameter>
+                  <Parameter id="ZxrZpYChKUe3DqPcdotiLQ" name="Fraction interstitial" description="Fraction of interstitial space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.188">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="19" source="Publication" description="Kawai R, Lemaire M, Steimer JL, Bruelisauer A, Niederberger W, Rowland M. Physiologically based pharmacokinetic study on a cyclosporin derivative, SDZ IMM 125. J Pharmacokinet Biopharm. 1994 Oct;22(5):327-65." />
+                    <Info min="0" max="1" flag="62" seq="62" ref="0" bb="32" group="64" />
+                  </Parameter>
+                  <Parameter id="Ha1ymprGSEisSCAAD6ghfw" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0215">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="22" source="Publication" description="Rodgers T, Rowland M. Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J Pharm Sci. 2006 Jun;95(6):1238-57 https://doi.org/10.1002/jps.20502" />
+                    <Info min="0" max="1" flag="122" seq="90" ref="0" bb="32" group="92" />
+                  </Parameter>
+                  <Parameter id="Z8BeYdWf0UuG9ZmTM0xUXg" name="Vf (neutral lipid)-WS" description="Fractional  cell volume content of neutral lipid used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0204">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="90" ref="0" bb="32" group="95" />
+                  </Parameter>
+                  <Parameter id="Aioa649lREGy8ARsMcDrUA" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0123">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="22" source="Publication" description="Rodgers T, Rowland M. Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J Pharm Sci. 2006 Jun;95(6):1238-57 https://doi.org/10.1002/jps.20502" />
+                    <Info min="0" max="1" flag="122" seq="91" ref="0" bb="32" group="92" />
+                  </Parameter>
+                  <Parameter id="QB9qG3ebzkyrYQHdSQxOxA" name="Vf (neutral phospholipid, plasma)-WS" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0152">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="91" ref="0" bb="32" group="95" />
+                  </Parameter>
+                  <Parameter id="zao_m8YwhE2fOv1OyPAozQ" name="Vf (extracellular water)-RR" description="Fractional tissue volume content of extracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.336">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="21" source="Publication" description="Rodgers T, Leahy D, Rowland M. Physiologically based pharmacokinetic modeling 1: predicting the tissue distribution of moderate-to-strong bases. J Pharm Sci. 2005 Jun;94(6):1259-76. https://doi.org/10.1002/jps.20322" />
+                    <Info min="0" max="1" flag="122" seq="92" ref="0" bb="32" group="92" />
+                  </Parameter>
+                  <Parameter id="XDWqbTi0kkuQHNTV15e0cw" name="Vf (protein)-WS" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.11">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="92" ref="0" bb="32" group="95" />
+                  </Parameter>
+                  <Parameter id="Lf4ZOtnJQke5NYPd8f0jhA" name="Vf (intracellular water)-RR" description="Fractional tissue volume content of intracellular water used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.238">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="22" source="Publication" description="Rodgers T, Rowland M. Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J Pharm Sci. 2006 Jun;95(6):1238-57 https://doi.org/10.1002/jps.20502" />
+                    <Info min="0" max="1" flag="122" seq="93" ref="0" bb="32" group="92" />
+                  </Parameter>
+                  <Parameter id="vVKp00TO3EyHCjOh4PLSfQ" name="Vf (water)-WS" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.74">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="93" ref="0" bb="32" group="95" />
+                  </Parameter>
+                  <Parameter id="AWKKSBh_eUORkldYnPTKtg" name="Acidic phospholipids [mg/g] - RR" description="Concentration of acidic phospholipids in tissue [mg/g] used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="3.91">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="21" source="Publication" description="Rodgers T, Leahy D, Rowland M. Physiologically based pharmacokinetic modeling 1: predicting the tissue distribution of moderate-to-strong bases. J Pharm Sci. 2005 Jun;94(6):1259-76. https://doi.org/10.1002/jps.20322" />
+                    <Info min="0" max="1000" flag="122" seq="94" ref="0" bb="32" group="92" />
+                  </Parameter>
+                  <Parameter id="QG7bGk_xr06s0mUDJCTvjA" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0044">
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="94" ref="0" bb="32" group="95" />
+                  </Parameter>
+                  <DistributedParameter id="PP9rr-JHn0ikdHQXD4ItIg" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="tw0kYzHbk0eOK0MbNgZJrw" mode="Logical" isDefault="1" displayUnit="l">
+                    <Children>
+                      <Parameter id="SJ4l0qo8kUWniVpTx5cdKQ" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.403636248736259">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="65" />
+                      </Parameter>
+                      <Parameter id="mo-yITrmD0qpZ2MYIeN6zw" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.2943497288" displayUnit="l">
+                        <Info min="0" flag="34" seq="1" ref="0" bb="32" group="65" />
+                      </Parameter>
+                      <Parameter id="wvCifhV1VE2aMPen7a0LAA" name="GeometricDeviation" description="Geometric standard deviation of LogNormal distribution" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.3">
+                        <Info min="1" flag="18" seq="1" ref="0" bb="32" group="65" />
+                      </Parameter>
+                      <Container id="EJ-6rJKJa02Ly5pz5ljg8w" name="Aciclovir" mode="Logical" containerType="Molecule" />
+                    </Children>
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
+                    <Info min="0" flag="106" seq="10" ref="0" bb="32" group="65" />
+                  </DistributedParameter>
+                  <DistributedParameter id="FBrRRwSXykGgb4XiEHa3Cw" name="Fraction vascular" description="Fraction of vascular space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="q6EMQsmWH0SqhoEsAj0QrQ" mode="Logical" isDefault="1">
+                    <Children>
+                      <Parameter id="ejLzhCK9t0mvA_cxpO2qTg" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="64" />
+                      </Parameter>
+                      <Parameter id="e-BfNg3qzk6GG0wMrfhe-Q" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.58">
+                        <Info min="0" max="1" flag="50" seq="1" ref="0" bb="32" group="64" />
+                      </Parameter>
+                      <Container id="NkjDOL57c0uSn6JaWmVbrw" name="Aciclovir" mode="Logical" containerType="Molecule" />
+                    </Children>
+                    <Tags>
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="40" source="Publication" description="Edginton, A.N., Schmitt, W. &amp; Willmann, S. Clin Pharmacokinet (2006) 45: 1013. https://doi.org/10.2165/00003088-200645100-00005" />
+                    <Info min="0" max="1" flag="62" seq="60" ref="0" bb="32" group="64" />
+                  </DistributedParameter>
+                  <Container id="HTpABK8mZ0aLnKny1tA6pA" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
+                    <Tags>
+                      <Tag value="Lung" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="NDwZwfdAPEGy--3dPdlrwg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="WiDWMA7xi02WdVvl1Rjr0g" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="KNm7d3n0h0CDvNofiIJE7Q" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="yYX4DjDwkEOGUvd-DF06pA" isDefault="1" displayUnit="l">
+                        <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                        <Info min="0" flag="62" seq="18" ref="0" bb="2" group="126" />
+                      </Parameter>
+                      <MoleculeAmount id="KD85ZSO_QkWu9LIBpArOHQ" name="CYP344" icon="ENZYME" persistable="0" isFixedValue="0" dim="Amount" quantityType="Enzyme" negativeValuesAllowed="0" formula="rMXLZglcaUaofPZ0c6I6Yw" mode="Logical" scaleDivisor="1" displayUnit="µmol">
+                        <Children>
+                          <Parameter id="mOO1i-Fn9ki2vAKBp_Hqsg" name="Degradation coefficient" description="First order turnover rate constant of the enzyme" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="c2fNMePAyki4XPdR-AEHaQ" isDefault="1" displayUnit="1/min">
+                            <ValueOrigin id="33" source="Other" description="OSP Suite Manual Chapter 16. PK-Sim®- Compounds: Defining inhibition/induction processes" />
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="udZl-X4mYUCtt95bHsA_uw" name="Relative expression" description="Relative expression" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="fqrxyq94VkWMTLJeRjjhEQ" isDefault="1">
+                            <Info min="0" flag="60" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="FiviJ8v8KkWCLbSqk1Lz3Q" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="YQ_SIzoIak2o9B3xCbLazA" isDefault="1">
+                            <Info min="0" flag="58" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="nuKCgEIPq0CAMulM6e29EA" name="Relative expression out." description="Relative Expression that will be used in the simulation" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="fbRCNZOks0i0JlaOaYnbvg" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="Ur0LJHw_vUaw9JEDPtN5HA" name="Start amount" description="Start amount of molecule" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" formula="EPX-QNxBZE2pcwiBNY6NfA" isDefault="1" displayUnit="µmol">
+                            <Info flag="54" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="Qm9BfYWLQUaAV4gPzjWTgw" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="_5AQF4X5mkuTWnIB24ghvw" isDefault="1" displayUnit="µmol/l">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Parameter id="QfvQeOIgzkqavZ4W_-wmuw" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="usrRjJLIf0WZstfSRe_1Mw" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                          </Parameter>
+                          <Parameter id="F8PUiI25PUC01quBZTjzqQ" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="GFFoZppBsU-rWguekXhpmA" isDefault="1" displayUnit="min">
+                            <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Observer id="DOMjt1XgIEGDIneDIv3B4w" name="Concentration in container" description="Concentration of the molecule" icon="Observer" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Enzyme, Observer" negativeValuesAllowed="1" formula="6wCmGaSt3UirOnRpXv6unA" displayUnit="µmol/l" />
+                        </Children>
+                      </MoleculeAmount>
+                      <MoleculeAmount id="7iG01UndskeLwYVQ2Lt8kw" name="Aciclovir" icon="DRUG" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" negativeValuesAllowed="0" mode="Logical" scaleDivisor="1" value="0" displayUnit="µmol">
+                        <Children>
+                          <Parameter id="3uYPHtizqkuoYm9ChjQHXQ" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="_5AQF4X5mkuTWnIB24ghvw" isDefault="1" displayUnit="µmol/l">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Parameter id="BMxSKXazokWL9cS9vQKrIg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="-RsVxJGWu0W-0STIQoTPPg" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                          </Parameter>
+                          <Observer id="n1dSEOPjfUyhveotp1_iDQ" name="Concentration in container" description="Concentration of the molecule" icon="Observer" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" negativeValuesAllowed="1" formula="6wCmGaSt3UirOnRpXv6unA" displayUnit="µmol/l" />
+                        </Children>
+                      </MoleculeAmount>
+                    </Children>
+                  </Container>
+                  <Container id="1ZY_zvMXA0GuV8WaXkkXmg" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
+                    <Tags>
+                      <Tag value="Lung" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="Mqx_Vy_yU0OnkCLLEaA1Fg" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="WiDWMA7xi02WdVvl1Rjr0g" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="NxYNMmTcPUG1eAXMfGM0Hw" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="H_SN9-_mbUGRPDaFmFf1dQ" isDefault="1" displayUnit="l">
+                        <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                        <Info min="0" flag="62" seq="18" ref="0" bb="2" group="121" />
+                      </Parameter>
+                      <MoleculeAmount id="nnpxmk1HHkeWu4lEyeNBzQ" name="CYP344" icon="ENZYME" persistable="0" isFixedValue="0" dim="Amount" quantityType="Enzyme" negativeValuesAllowed="0" formula="rMXLZglcaUaofPZ0c6I6Yw" mode="Logical" scaleDivisor="1" displayUnit="µmol">
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+                          <Parameter id="ZNgDY7tLlUm4IK0stmMdaw" name="Degradation coefficient" description="First order turnover rate constant of the enzyme" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="c2fNMePAyki4XPdR-AEHaQ" isDefault="1" displayUnit="1/min">
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+                  </DistributedParameter>
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+                    <Children>
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+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="92" />
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+                      <Parameter id="9GeDJD32R0CUAFj4PdteNQ" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.666">
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+                      <Parameter id="4SGCMhvzH0OGN95S-p6tFw" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="95" />
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+                      <Parameter id="lzQllt8r40mLcC6C6M-TLw" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.76">
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+                      <Tag value="TissueOrgan" />
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+                  <DistributedParameter id="-HK4Mb0HIk-TMiuSnIdFXw" name="Specific blood flow rate" description="Blood flow rate normalized to the organ volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" formula="w8kM62OE30q35Rzz_7okdA" mode="Logical" isDefault="1" displayUnit="ml/min/100g organ">
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+                      <Parameter id="SnhEVnZXw0iwKfcgU9Ravw" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
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+                      <Parameter id="e9S09O9N6UC_vruUk25t4A" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.03419" displayUnit="ml/min/100g organ">
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+                      <Parameter id="-GtS_fHfkU-pvnw-vceN9w" name="Deviation" description="Standard deviation of Normal distribution" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0017095" displayUnit="ml/min/100g organ">
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+                    </Tags>
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+                    <Tags>
+                      <Tag value="Muscle" />
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+                      <Parameter id="s9HN7OpJ4UmZh3QbAUQxPQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="WiDWMA7xi02WdVvl1Rjr0g" isDefault="1" displayUnit="l">
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+                          <Parameter id="7HdTw8g_UkarEwCmc4yXtA" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="uFrPp0zroUS0px_NuyuVDw" isDefault="1">
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+                            <Info min="0" flag="60" seq="1" ref="0" bb="2" group="91" />
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+                          <Parameter id="VTfYLayTDUeohkibhxxQog" name="Relative expression out." description="Relative Expression that will be used in the simulation" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="fbRCNZOks0i0JlaOaYnbvg" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="91" />
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+                          <Parameter id="kDI0yZAeC02higLGJbijzQ" name="Start amount" description="Start amount of molecule" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" formula="EPX-QNxBZE2pcwiBNY6NfA" isDefault="1" displayUnit="µmol">
+                            <Info flag="54" seq="1" ref="0" bb="2" group="91" />
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+                          <Parameter id="UUh8FdkMlkCSQoJ5MkiM6w" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="os37bGoXREWk4Xu-spTLrQ" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
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+                          <Parameter id="_0JulVz3IkaJNuvYCeargA" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="fD61rN7zRkmOKa6plUiGvQ" isDefault="1" displayUnit="min">
+                            <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
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+                            <Info min="0" flag="18" seq="1" ref="0" bb="2" group="117" />
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+                          <Parameter id="73iKdWvkekWBzlH99IhwdQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="yMrPmuSOA0CDgXlUMFUOSA" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
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+                      <Tag value="Muscle" />
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+                      <Parameter id="fK21EdvyLEOIkbdx5AUZgw" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="WiDWMA7xi02WdVvl1Rjr0g" isDefault="1" displayUnit="l">
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+                      </Parameter>
+                      <Parameter id="lXcUUjhnJ0-ZbsaZBifZ-A" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="9uWm2G1z9EK-p6oBMLbcVA" isDefault="1" displayUnit="l">
+                        <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                        <Info min="0" flag="62" seq="19" ref="0" bb="2" group="124" />
+                      </Parameter>
+                      <Parameter id="dmffZGP3Y02Ycg-vH8lv_g" name="pH" description="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="eK4DKfgMbEONwPdNpejUig" isDefault="1">
+                        <Tags>
+                          <Tag value="Muscle" />
+                        </Tags>
+                        <Info min="0" max="14" flag="122" seq="59" ref="0" bb="32" group="84" />
+                      </Parameter>
+                      <MoleculeAmount id="tia5cEbIpEuME7LoZw6CFA" name="Aciclovir" icon="DRUG" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" negativeValuesAllowed="0" mode="Logical" scaleDivisor="1" value="0" displayUnit="µmol">
+                        <Children>
+                          <Parameter id="ssj_xrFbU0eQS73is-L5Aw" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="_5AQF4X5mkuTWnIB24ghvw" isDefault="1" displayUnit="µmol/l">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Parameter id="9WQWkdt_KUe3fIxUUqXNeQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="wDhoA7P9DESJOjfUg68AqA" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                          </Parameter>
+                          <Observer id="Cl1H0aM6Z0OuYZd6BJ5DUw" name="Concentration in container" description="Concentration of the molecule" icon="Observer" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" negativeValuesAllowed="1" formula="6wCmGaSt3UirOnRpXv6unA" displayUnit="µmol/l" />
+                        </Children>
+                      </MoleculeAmount>
+                    </Children>
+                  </Container>
+                  <Container id="PUFT_Rx-L0qXs1RoNWy8Kg" name="Intracellular" description="Intracellular" icon="Intracellular" mode="Physical" containerType="Compartment">
+                    <Tags>
+                      <Tag value="Muscle" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="xcK5VIm1aEurUKXM3N3xvQ" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="J_zsXA_hVEGtRM46zqPvJg" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="Dl2nR7wohUOt_--HH5l-Pg" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="GXZJgB5-lEOADgF16J9WjQ" isDefault="1" displayUnit="l">
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+                        <Info min="0" flag="62" seq="19" ref="0" bb="2" group="125" />
+                      </Parameter>
+                      <Parameter id="LrFe9ZXcb0qLXzmUV3K8cw" name="pH" description="pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="6.81">
+                        <Tags>
+                          <Tag value="Muscle" />
+                        </Tags>
+                        <ValueOrigin id="34" source="Publication" description="Toxicol In Vitro. 2008 Mar;22(2):457-67 https://doi.org/10.1016/j.tiv.2007.09.010" />
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+                      </Parameter>
+                      <MoleculeAmount id="6gx2IMLzO0WqT-iqpNrfnw" name="CYP344" icon="ENZYME" persistable="0" isFixedValue="0" dim="Amount" quantityType="Enzyme" negativeValuesAllowed="0" formula="rMXLZglcaUaofPZ0c6I6Yw" mode="Logical" scaleDivisor="1" displayUnit="µmol">
+                        <Children>
+                          <Parameter id="PU41npBzi0iy7LWlqPnvNA" name="Degradation coefficient" description="First order turnover rate constant of the enzyme" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="c2fNMePAyki4XPdR-AEHaQ" isDefault="1" displayUnit="1/min">
+                            <ValueOrigin id="33" source="Other" description="OSP Suite Manual Chapter 16. PK-Sim®- Compounds: Defining inhibition/induction processes" />
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="kaOj38pWt0SuwTl3OJK9fg" name="Relative expression" description="Relative expression" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0">
+                            <Info min="0" flag="60" seq="1" ref="0" bb="32" group="91" />
+                          </Parameter>
+                          <Parameter id="EmltX3K7W0Sw-d6AwX6_Tw" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0">
+                            <Info min="0" flag="58" seq="1" ref="0" bb="32" group="91" />
+                          </Parameter>
+                          <Parameter id="J4X5YVQz5kuPITkh-nQBdg" name="Relative expression out." description="Relative Expression that will be used in the simulation" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="fbRCNZOks0i0JlaOaYnbvg" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="91" />
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+                          <Parameter id="2D2Fi-XIvkGligJIw9dK8Q" name="Start amount" description="Start amount of molecule" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" formula="EPX-QNxBZE2pcwiBNY6NfA" isDefault="1" displayUnit="µmol">
+                            <Info flag="54" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="8JaDZgOnvkasBiho8q9EWg" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="_5AQF4X5mkuTWnIB24ghvw" isDefault="1" displayUnit="µmol/l">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Parameter id="jkKi0zuLTkaUhfv_WAgwRQ" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="3RnpkLT5k02MQopaCGPTaw" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                          </Parameter>
+                          <Parameter id="LBMmWWNtgk6K9plVnJgZ0w" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="by5yO5jv5UeXmdKCnhR6kg" isDefault="1" displayUnit="min">
+                            <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Observer id="uQE2GeRM1EuNuP1e-tiiuw" name="Concentration in container" description="Concentration of the molecule" icon="Observer" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Enzyme, Observer" negativeValuesAllowed="1" formula="6wCmGaSt3UirOnRpXv6unA" displayUnit="µmol/l" />
+                        </Children>
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+                      <MoleculeAmount id="YOBh6JO72U-D7HyHLSvVsg" name="Aciclovir" icon="DRUG" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" negativeValuesAllowed="0" mode="Logical" scaleDivisor="1" value="0" displayUnit="µmol">
+                        <Children>
+                          <Parameter id="rue54XOjPUKvMNhC42GzNA" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="_5AQF4X5mkuTWnIB24ghvw" isDefault="1" displayUnit="µmol/l">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Parameter id="H3xblrFbO02s0j2FbTgNyg" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="mcO-48KLW0W2UtBbVQUprA" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                          </Parameter>
+                          <Observer id="PhVefO5rRUiPx_AD_3Wjag" name="Concentration in container" description="Concentration of the molecule" icon="Observer" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" negativeValuesAllowed="1" formula="6wCmGaSt3UirOnRpXv6unA" displayUnit="µmol/l" />
+                        </Children>
+                      </MoleculeAmount>
+                    </Children>
+                  </Container>
+                  <Container id="-rH6nBrw9kyMDPH_bVgT_w" name="Aciclovir" mode="Logical" containerType="Molecule">
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+                      <Observer id="kc6X5wedoEuM2rAfIG_1mA" name="Interstitial Unbound" description="Interstitial Unbound" icon="Observer" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" negativeValuesAllowed="1" formula="9puGFowK4EWaB_uKiCUkZg" displayUnit="µmol/l" />
+                      <Observer id="OrtnUh8uJkO3c4DIjdjvdg" name="Intracellular Unbound" description="Intracellular Unbound" icon="Observer" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" negativeValuesAllowed="1" formula="teOQNDXPokGxR8_kXybQ_A" displayUnit="µmol/l" />
+                      <Observer id="LlImfJfgW0yW9vQhpUGqQw" name="Tissue" description="Tissue" icon="Observer" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" negativeValuesAllowed="1" formula="vXvnx5OPgEOFlJ6Oq1kSGw" displayUnit="µmol/l" />
+                    </Children>
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+                </Children>
+              </Container>
+              <Container id="JgBB1B1ZAEqvkpkO2qW0JA" name="Pancreas" description="Pancreas" icon="Pancreas" mode="Logical" containerType="Organ">
+                <Tags>
+                  <Tag value="Portal Vein Supplying Organ" />
+                  <Tag value="TissueOrgan" />
+                </Tags>
+                <Children>
+                  <Parameter id="7rd1R9cuSE6L8F0OhxqOaw" name="Weight (tissue)" description="Weight of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Mass" quantityType="Parameter" negativeValuesAllowed="1" formula="fliUWazsPUiRy_qjzM6EaA" isDefault="1" displayUnit="kg">
+                    <Tags>
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+                    </Tags>
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+                  </Parameter>
+                  <Parameter id="Sqo09it0YUqYQ7YD_iV6Yg" name="Fluid recirculation flow rate" description="Fluid recirculation flow rate between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="SEONXx9l8UekWRlG-vCS6A" isDefault="1" displayUnit="l/min">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
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+                  </Parameter>
+                  <Parameter id="z5APK1MVCEGaLa0WhrElhw" name="Lymph flow rate" description="Lymph flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="AHUOFh7VvEGdn9pbFbN0Ng" isDefault="1" displayUnit="l/min">
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+                    <Info min="0" flag="122" seq="20" ref="0" bb="32" group="58" />
+                  </Parameter>
+                  <Parameter id="feFRTKpOtUu3V2iyldlU0g" name="Volume (endothelium)" description="Volume of  vascular endothelium" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="orPBF6zbA0S25upi_ry81w" isDefault="1" displayUnit="l">
+                    <Tags>
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+                    <Info min="0" flag="62" seq="20" ref="0" bb="32" group="127" />
+                  </Parameter>
+                  <Parameter id="h92yS16Idk-lAVlYvzKmRw" name="Fraction intracellular" description="Fraction of intracellular space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="I-HZynBcWEaZVIcFkF3iMQ" isDefault="1">
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+                    <Info min="0" max="1" flag="62" seq="67" ref="0" bb="32" group="64" />
+                  </Parameter>
+                  <Parameter id="Xdv5DNbJSEOxUPcomYXENA" name="Blood flow rate" description="Organ blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="y6LwIbRu9ku8erXKf1RN9w" isDefault="1" displayUnit="l/min">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
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+                  </Parameter>
+                  <Parameter id="5Qb6nNnNO02TfPHC3Ll69A" name="Density (tissue)" description="Density of tissue" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
+                    <Tags>
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+                    <Info min="0" flag="38" seq="1" ref="0" bb="32" group="21" />
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+                  <Parameter id="PDpiOsgqoECe-7I8m8phRQ" name="Fluid recirculation flow proportionality factor" description="proportionality factor linking fluid recirculation flow to lymph flow via small pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.01">
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+                    <Tags>
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+                  <Parameter id="hDVZcygxTUCx1_Bs7rcncg" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.75">
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+                    <Info min="0.75" max="0.75" flag="54" seq="1" ref="0" bb="32" group="2" />
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+                  </Parameter>
+                  <Parameter id="l3TXzUDH50msEJpdkDLSIA" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.05">
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+                  <Parameter id="uZRlcbzZaEKVoq6iOejLqw" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" icon="Parameter" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="3.22222222222222E-11" displayUnit="ml/min/N">
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+                  <Parameter id="TCfmVL25QU26s7yiVEUvow" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.13">
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+                    <Info min="0" max="1" flag="122" seq="61" ref="0" bb="32" group="85" />
+                  </Parameter>
+                  <Parameter id="qC6Fr-3v5kiwyZ83aGwDvA" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.06">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
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+                    <Info min="0" max="1" flag="122" seq="62" ref="0" bb="32" group="111" />
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+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
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+                    <ValueOrigin id="24" source="Publication" description="POULIN P, THEIL F. Prediction of Pharmacokinetics Prior to In Vivo Studies. 1. Mechanism-Based Prediction of Volume of Distribution. JOURNAL OF PHARMACEUTICAL SCIENCES, VOL. 91, NO. 1, JANUARY 2002" />
+                    <Info min="0" max="1" flag="122" seq="62" ref="0" bb="32" group="112" />
+                  </Parameter>
+                  <Parameter id="B2ZIhxrWF0--dXdt-T0UdQ" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.06">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
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+                    <Info min="0" max="1" flag="122" seq="62" ref="0" bb="32" group="113" />
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+                  <Parameter id="44DDHwjWLUOmsSD8nxbitA" name="Vf (water)" description="Fractional tissue volume content of water used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.71">
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+                    <Info min="0" max="1" flag="122" seq="62" ref="0" bb="32" group="85" />
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+                    <Info min="0" max="1" flag="62" seq="66" ref="0" bb="32" group="64" />
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+                  <Parameter id="y6uB_2jx906gtBqzVxfbJA" name="Fraction interstitial" description="Fraction of interstitial space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.12">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
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+                    <ValueOrigin id="19" source="Publication" description="Kawai R, Lemaire M, Steimer JL, Bruelisauer A, Niederberger W, Rowland M. Physiologically based pharmacokinetic study on a cyclosporin derivative, SDZ IMM 125. J Pharmacokinet Biopharm. 1994 Oct;22(5):327-65." />
+                    <Info min="0" max="1" flag="62" seq="68" ref="0" bb="32" group="64" />
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+                  <Parameter id="jD2NaChoWEW7YHyoagnnKA" name="Vf (neutral lipid)-RR" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0403">
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+                    <Tags>
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+                    <Info min="0" max="1" flag="122" seq="100" ref="0" bb="32" group="95" />
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+                  <Parameter id="Ww5FdA3IoEyaCzUsQr7a7g" name="Vf (neutral phospholipid)-RR" description="Fractional cell volume content of neutral phospholipid used in the partition coefficient calculation method 'Rodgers and Rowland'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.009">
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+                    <Info min="0" max="1" flag="122" seq="101" ref="0" bb="32" group="95" />
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+                    <Info min="0" max="1" flag="122" seq="102" ref="0" bb="32" group="92" />
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+                    <Info min="0" max="1" flag="122" seq="102" ref="0" bb="32" group="95" />
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+                    <Info min="0" max="1" flag="122" seq="103" ref="0" bb="32" group="92" />
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+                    <Info min="0" max="1" flag="122" seq="103" ref="0" bb="32" group="95" />
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+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
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+                    <Info min="0" max="1000" flag="122" seq="104" ref="0" bb="32" group="92" />
+                  </Parameter>
+                  <Parameter id="0fTUDMFYaEO1AV6kh8wxKA" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.00167">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
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+                    <Info min="0" max="1" flag="122" seq="104" ref="0" bb="32" group="95" />
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+                  <DistributedParameter id="QuPJjpIE6EKfavGmVQfQHg" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="Ng7FMWZJTUaO5xAcNRId9A" mode="Logical" isDefault="1" displayUnit="l">
+                    <Children>
+                      <Parameter id="Slp0mxvm7ked215DpQ2rBw" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.501571763654894">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="65" />
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+                      <Parameter id="vre7K6cackqUpoH9rzq-tQ" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.19026527664" displayUnit="l">
+                        <Info min="0" flag="34" seq="1" ref="0" bb="32" group="65" />
+                      </Parameter>
+                      <Parameter id="-QZID2ld-0m813w23NHejg" name="Deviation" description="Standard deviation of Normal distribution" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.051153121992552" displayUnit="l">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="65" />
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+                      <Container id="cUlUcyA7JkOYrdgCL0IWgg" name="Aciclovir" mode="Logical" containerType="Molecule" />
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+                    <Info min="0" flag="106" seq="12" ref="0" bb="32" group="65" />
+                  </DistributedParameter>
+                  <DistributedParameter id="4_vuxgUI0Em9W8BxsoY2Gw" name="Specific blood flow rate" description="Blood flow rate normalized to the organ volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" formula="S75bkVAw3Eqa3HEpwuZw-Q" mode="Logical" isDefault="1" displayUnit="ml/min/100g organ">
+                    <Children>
+                      <Parameter id="X4Wr2DX7xUeH-5T_PIvq9g" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="5" />
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+                      <Parameter id="b8_Q6EBRaEingaWI-GPQCg" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.3419" displayUnit="ml/min/100g organ">
+                        <Info min="0" flag="50" seq="1" ref="0" bb="32" group="5" />
+                      </Parameter>
+                      <Parameter id="1YSrgv78T0CsT36M3tFYcA" name="Deviation" description="Standard deviation of Normal distribution" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.017095" displayUnit="ml/min/100g organ">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="5" />
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+                      <Container id="lRVEy-GVVEuc0BNVhYp-RA" name="Aciclovir" mode="Logical" containerType="Molecule" />
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+                    <Info min="0" flag="122" seq="181" ref="0" bb="32" group="5" />
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+                  <Container id="5C6Dv04n9EGG4vtDsR-UpQ" name="Plasma" description="Plasma" icon="Plasma" mode="Physical" containerType="Compartment">
+                    <Tags>
+                      <Tag value="Pancreas" />
+                      <Tag value="Portal Vein Supplying Organ" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="6W0G6OrpY0SE4mE0XMqI4w" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="WiDWMA7xi02WdVvl1Rjr0g" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
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+                      <Parameter id="PGMH4L7tjkqAovsd4iipjA" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="yYX4DjDwkEOGUvd-DF06pA" isDefault="1" displayUnit="l">
+                        <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                        <Info min="0" flag="62" seq="20" ref="0" bb="2" group="126" />
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+                      <MoleculeAmount id="dp_k5jKtiECZXUKe8c6_Iw" name="CYP344" icon="ENZYME" persistable="0" isFixedValue="0" dim="Amount" quantityType="Enzyme" negativeValuesAllowed="0" formula="rMXLZglcaUaofPZ0c6I6Yw" mode="Logical" scaleDivisor="1" displayUnit="µmol">
+                        <Children>
+                          <Parameter id="LZ2A6xzTvUaWw_ZL3X2Oow" name="Degradation coefficient" description="First order turnover rate constant of the enzyme" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="c2fNMePAyki4XPdR-AEHaQ" isDefault="1" displayUnit="1/min">
+                            <ValueOrigin id="33" source="Other" description="OSP Suite Manual Chapter 16. PK-Sim®- Compounds: Defining inhibition/induction processes" />
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="pt7Pg2RRkkeyNm8qyR2O5w" name="Relative expression" description="Relative expression" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="fqrxyq94VkWMTLJeRjjhEQ" isDefault="1">
+                            <Info min="0" flag="60" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="lcPsC9qPjESMVkIA8hBe-Q" name="Relative expression (normalized)" description="Relative expression normalized to maximal value in organ" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="YQ_SIzoIak2o9B3xCbLazA" isDefault="1">
+                            <Info min="0" flag="58" seq="1" ref="0" bb="2" group="91" />
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+                          <Parameter id="IWzPHbhk_0mjBwvyB8CyCw" name="Relative expression out." description="Relative Expression that will be used in the simulation" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="fbRCNZOks0i0JlaOaYnbvg" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="kgFKia52YESAuh6o3c79fg" name="Start amount" description="Start amount of molecule" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" formula="EPX-QNxBZE2pcwiBNY6NfA" isDefault="1" displayUnit="µmol">
+                            <Info flag="54" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Parameter id="qeiHXPTnV02oNazBKFWcPA" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="_5AQF4X5mkuTWnIB24ghvw" isDefault="1" displayUnit="µmol/l">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Parameter id="GnHaPe0fDU29QY6Aq8CTqw" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="tKkYqxt2BU2-vsxR7ba3wg" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
+                          </Parameter>
+                          <Parameter id="t_13--b8x0Sq2U8tQfzLmA" name="t1/2" description="Half-life of drug release" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="fYVol-wdEUeNzZxB6zpTrA" isDefault="1" displayUnit="min">
+                            <Info min="0" flag="38" seq="1" ref="0" bb="2" group="91" />
+                          </Parameter>
+                          <Observer id="Vb-6lxZNG0uH7foHqO5l6A" name="Concentration in container" description="Concentration of the molecule" icon="Observer" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Enzyme, Observer" negativeValuesAllowed="1" formula="6wCmGaSt3UirOnRpXv6unA" displayUnit="µmol/l" />
+                        </Children>
+                      </MoleculeAmount>
+                      <MoleculeAmount id="AdODwmUjQk69oFXjb-S1SA" name="Aciclovir" icon="DRUG" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" negativeValuesAllowed="0" mode="Logical" scaleDivisor="1" value="0" displayUnit="µmol">
+                        <Children>
+                          <Parameter id="wA285l4NuU2p7FTM6Kpcug" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="_5AQF4X5mkuTWnIB24ghvw" isDefault="1" displayUnit="µmol/l">
+                            <Info min="0" flag="18" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                          <Parameter id="gSRyH1QDVkm3JIUZHG_mDQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="PW4CaPaVXESq4iXpcP85Qg" isDefault="1">
+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="67" />
+                          </Parameter>
+                          <Observer id="yqgPAoJnEEiHYPZHRsjxNQ" name="Concentration in container" description="Concentration of the molecule" icon="Observer" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" negativeValuesAllowed="1" formula="6wCmGaSt3UirOnRpXv6unA" displayUnit="µmol/l" />
+                        </Children>
+                      </MoleculeAmount>
+                    </Children>
+                  </Container>
+                  <Container id="i_uU7NwDCEeD0Ik1qMIqWA" name="BloodCells" description="Blood Cells" icon="BloodCells" mode="Physical" containerType="Compartment">
+                    <Tags>
+                      <Tag value="Pancreas" />
+                      <Tag value="Portal Vein Supplying Organ" />
+                    </Tags>
+                    <Children>
+                      <Parameter id="uVYmPpAwoky-3KgyInme7A" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="WiDWMA7xi02WdVvl1Rjr0g" isDefault="1" displayUnit="l">
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+                      <Tag value="BloodOrgan" />
+                      <Tag value="PortalVein" />
+                    </Tags>
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+                        </Children>
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+                        </Children>
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+                <Tags>
+                  <Tag value="TissueOrgan" />
+                </Tags>
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+                  <Parameter id="HYB9px8MsEq040L11W9zYA" name="Fraction vascular" description="Fraction of vascular space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.046">
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+                      <Tag value="TissueOrgan" />
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+                      <Tag value="TissueOrgan" />
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+                    <ValueOrigin id="42" source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
+                    <Info min="0" max="1" flag="122" seq="69" ref="0" bb="32" group="85" />
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+                    <Tags>
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+                    </Tags>
+                    <Info min="0" max="1" flag="122" seq="69" ref="0" bb="32" group="86" />
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+                    <Info min="0" max="1" flag="122" seq="70" ref="0" bb="32" group="86" />
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+                    <Info min="0" max="1" flag="122" seq="70" ref="0" bb="32" group="85" />
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+                  <Parameter id="1YuOw7Me-UqrPvLzatWGqQ" name="Albumin ratio (tissue/plasma)" description="Ratio of albumin concentration found in tissue vs. plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.277">
+                    <Tags>
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+                    <Info min="0" max="1" flag="122" seq="71" ref="0" bb="32" group="111" />
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+                    <Tags>
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+                    <Info min="0" max="1" flag="122" seq="71" ref="0" bb="32" group="112" />
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+                    <Info min="0" max="1" flag="122" seq="71" ref="0" bb="32" group="86" />
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+                  <Parameter id="kOmD7K7Nw0STOoue1kzJuA" name="Fraction interstitial" description="Fraction of interstitial space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.302">
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+                    <ValueOrigin id="19" source="Publication" description="Kawai R, Lemaire M, Steimer JL, Bruelisauer A, Niederberger W, Rowland M. Physiologically based pharmacokinetic study on a cyclosporin derivative, SDZ IMM 125. J Pharmacokinet Biopharm. 1994 Oct;22(5):327-65." />
+                    <Info min="0" max="1" flag="62" seq="72" ref="0" bb="32" group="64" />
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+                    <Info min="0" max="1" flag="122" seq="115" ref="0" bb="32" group="92" />
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+                    <Info min="0" max="1" flag="122" seq="116" ref="0" bb="32" group="92" />
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+                    <Info min="0" max="1" flag="122" seq="117" ref="0" bb="32" group="92" />
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+                    <Info min="0" max="1" flag="122" seq="118" ref="0" bb="32" group="92" />
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+                    <Info min="0" max="1000" flag="122" seq="119" ref="0" bb="32" group="92" />
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+                    <Children>
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+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="65" />
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+                        <Info min="0" flag="34" seq="1" ref="0" bb="32" group="65" />
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+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="65" />
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+                    <Info min="0" flag="106" seq="15" ref="0" bb="32" group="65" />
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+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="5" />
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+                      <Parameter id="ZXbIGAzmoUit2Q2PbcfOTA" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.08645" displayUnit="ml/min/100g organ">
+                        <Info min="0" flag="50" seq="1" ref="0" bb="32" group="5" />
+                      </Parameter>
+                      <Parameter id="HWSTQQTEDkueFUsg9xx76Q" name="Deviation" description="Standard deviation of Normal distribution" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow per weight organ" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0043225" displayUnit="ml/min/100g organ">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="5" />
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+                      <Parameter id="d0sH_n3Yv0OIlkeRAkI76A" name="Volume of protein container" description="Volume of organ/compartment where the protein cocentration was measured" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="WiDWMA7xi02WdVvl1Rjr0g" isDefault="1" displayUnit="l">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
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+                      <Parameter id="h2RpAx1l3ECIoDO1PA4AXg" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="yYX4DjDwkEOGUvd-DF06pA" isDefault="1" displayUnit="l">
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+                        <Info min="0" flag="62" seq="23" ref="0" bb="2" group="126" />
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+                      <MoleculeAmount id="QxQMWusgdEWTv4FJpmZXPA" name="CYP344" icon="ENZYME" persistable="0" isFixedValue="0" dim="Amount" quantityType="Enzyme" negativeValuesAllowed="0" formula="rMXLZglcaUaofPZ0c6I6Yw" mode="Logical" scaleDivisor="1" displayUnit="µmol">
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+                          <Parameter id="S8Z4EPcOzkKogEDoDBv46Q" name="Relative expression" description="Relative expression" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="fqrxyq94VkWMTLJeRjjhEQ" isDefault="1">
+                            <Info min="0" flag="60" seq="1" ref="0" bb="2" group="91" />
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+                            <Info min="0" flag="52" seq="1" ref="0" bb="2" group="142" />
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+                  </Parameter>
+                  <Parameter id="GowXj29F2kq7OvfcqxVO6w" name="Blood flow rate" description="Organ blood flow rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="y6LwIbRu9ku8erXKf1RN9w" isDefault="1" displayUnit="l/min">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <ValueOrigin id="48" source="Other" description="Absolute value = specific value (i.e. value normalized to the volume of the organ) multiplied by the organ volume" />
+                    <Info min="0" flag="62" seq="242" ref="0" bb="32" group="5" />
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+                  <Parameter id="4Gi3o5fw-Ee-f5WRAyDkBg" name="Density (tissue)" description="Density of tissue" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1" displayUnit="g/cm³">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
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+                    <Info min="0" flag="38" seq="1" ref="0" bb="32" group="21" />
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+                  <Parameter id="MkyXLn4SBUqXewMDjtKthQ" name="Fluid recirculation flow proportionality factor" description="proportionality factor linking fluid recirculation flow to lymph flow via small pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.01">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
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+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="27" />
+                  </Parameter>
+                  <Parameter id="bColMdglykiHIs6VkIplqw" name="Lymph flow proportionality factor" description="Proportionality factor linking lymph flow to plasma flow" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0199">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
+                    </Tags>
+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="58" />
+                  </Parameter>
+                  <Parameter id="b_SpuDZl90Cy683DpY30pg" name="Organ volume mouse" description="Organ volume mouse" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0001" displayUnit="l">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
+                      <Tag value="TissueOrgan" />
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+                    <Info min="0" flag="54" seq="1" ref="0" bb="32" group="65" />
+                  </Parameter>
+                  <Parameter id="eWqnL4UNSk6wrbkXNp2CQg" name="Allometric scale factor" description="Allometric scaling for calculating of permeability surface area products for organs" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.75">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
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+                    <Info min="0.75" max="0.75" flag="54" seq="1" ref="0" bb="32" group="2" />
+                  </Parameter>
+                  <Parameter id="HXJ-Zyc6gEa2VI7_BAztIA" name="Fraction of blood for sampling" description="fraction of blood for sampling observer" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
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+                      <Tag value="Portal Vein Supplying Organ" />
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+                    <Info min="0" max="1" flag="54" seq="1" ref="0" bb="32" group="94" />
+                  </Parameter>
+                  <Parameter id="lPvqe8eutU2ZJBi_0MSMZg" name="Flow fraction via large pores" description="Fraction of fluid flow via large endothelial pores" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.8">
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+                      <Tag value="Portal Vein Supplying Organ" />
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+                    <Info min="0" max="1" flag="122" seq="24" ref="0" bb="32" group="114" />
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+                  <Parameter id="xdTwQVXZXk-dwcbzlxbsVQ" name="Hydraulic conductivity" description="Hydraulic conductivity of vascular endothelium" icon="Parameter" persistable="0" isFixedValue="0" dim="Hydraulic conductivity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="3.88888888888889E-11" displayUnit="ml/min/N">
+                    <Tags>
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+                    <Info min="0" flag="122" seq="24" ref="0" bb="32" group="115" />
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+                  <Parameter id="yk0tEUznQEigZf1iShEPpg" name="Radius (large pores)" description="Large endothelial pores radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="3.3E-07" displayUnit="µm">
+                    <Tags>
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+                    <Info min="0" flag="122" seq="24" ref="0" bb="32" group="55" />
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+                    <Info min="0" flag="122" seq="24" ref="0" bb="32" group="99" />
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+                  <Parameter id="8aDNM_Tc20CyYvRU7oqO2g" name="Vf (lipid)" description="Fractional tissue volume content of lipid used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.016">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
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+                    <Info min="0" max="1" flag="122" seq="72" ref="0" bb="32" group="85" />
+                  </Parameter>
+                  <Parameter id="izigYU4sj0-PRSdfkBG_ww" name="Vf (neutral lipid)-PT" description="Fractional cell volume content of neutral lipid used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0201">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
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+                    <Info min="0" max="1" flag="122" seq="72" ref="0" bb="32" group="86" />
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+                  <Parameter id="u8T5v4PVFUG5i3ykjBC8QA" name="Fraction vascular" description="Fraction of vascular space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.33">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
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+                    <Info min="0" max="1" flag="62" seq="73" ref="0" bb="32" group="64" />
+                  </Parameter>
+                  <Parameter id="A2OuXpLL7kedcM0aOtqqjA" name="Vf (phospholipid)-PT" description="Fractional tissue volume content of phospholipid used in the partition coefficient calculation method 'Poulin and Theil'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.0198">
+                    <Tags>
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+                    <Info min="0" max="1" flag="122" seq="73" ref="0" bb="32" group="86" />
+                  </Parameter>
+                  <Parameter id="9XAcBc7UGkW4riidFTQE3g" name="Vf (protein)" description="Fractional tissue volume content of protein used in the partition coefficient calculation method 'PK-Sim Standard'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.194">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
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+                    <Info min="0" max="1" flag="122" seq="73" ref="0" bb="32" group="85" />
+                  </Parameter>
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+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
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+                    <Info min="0" max="1" flag="122" seq="74" ref="0" bb="32" group="111" />
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+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
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+                    <Info min="0" max="1" flag="122" seq="74" ref="0" bb="32" group="112" />
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+                  <Parameter id="hekSxrgCd0Gl-wGK8dw7NA" name="Lipoprotein ratio (tissue/plasma)" description="Ratio of lipoprotein concentration found in tissue vs. plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.207">
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+                    <Info min="0" max="1" flag="122" seq="74" ref="0" bb="32" group="113" />
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+                    <Tags>
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+                    <Info min="0" max="1" flag="122" seq="74" ref="0" bb="32" group="85" />
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+                    <Tags>
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+                    <Info min="0" max="1" flag="122" seq="74" ref="0" bb="32" group="86" />
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+                  <Parameter id="2e4cOSYld0CjMLo_Kgv30Q" name="Fraction interstitial" description="Fraction of interstitial space of the organ" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.15">
+                    <Tags>
+                      <Tag value="Portal Vein Supplying Organ" />
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+                    <ValueOrigin id="19" source="Publication" description="Kawai R, Lemaire M, Steimer JL, Bruelisauer A, Niederberger W, Rowland M. Physiologically based pharmacokinetic study on a cyclosporin derivative, SDZ IMM 125. J Pharmacokinet Biopharm. 1994 Oct;22(5):327-65." />
+                    <Info min="0" max="1" flag="62" seq="75" ref="0" bb="32" group="64" />
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+                    <Info min="0" max="1" flag="122" seq="120" ref="0" bb="32" group="92" />
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+                    <Info min="0" max="1" flag="122" seq="120" ref="0" bb="32" group="95" />
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+                    <Info min="0" max="1" flag="122" seq="122" ref="0" bb="32" group="92" />
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+                    <Info min="0" max="1" flag="122" seq="123" ref="0" bb="32" group="92" />
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+                    <Info min="0" max="1000" flag="122" seq="124" ref="0" bb="32" group="92" />
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+                  <Parameter id="iOP3cpqfHEGpd8vFVeXwbw" name="Vf (acidic phospholipids)-WS" description="Fractional cell volume content of acidic phospholipids used in the partition coefficient calculation method 'Schmitt'" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.003">
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+                    <Info min="0" max="1" flag="122" seq="124" ref="0" bb="32" group="95" />
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+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="65" />
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+                      <Parameter id="fQesRpaXcEu7ZdLq9OGeCQ" name="Mean" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.24341181216" displayUnit="l">
+                        <Info min="0" flag="34" seq="1" ref="0" bb="32" group="65" />
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+                      <Parameter id="n1GXtmY4Ek2ZaNIQsND_uA" name="GeometricDeviation" description="Geometric standard deviation of LogNormal distribution" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1.5">
+                        <Info min="1" flag="18" seq="1" ref="0" bb="32" group="65" />
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+                      <Container id="ShWHpFQVCkujl-VpW7YMuQ" name="Aciclovir" mode="Logical" containerType="Molecule" />
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+                    <Children>
+                      <Parameter id="s9ecneMNO0C_6sfmrabHiw" name="Percentile" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0.5">
+                        <Info min="0" flag="18" seq="1" ref="0" bb="32" group="5" />
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+                        </Children>
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+                        <Children>
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+                          <Parameter id="KWMNQE1khEaDMMDHAOy1hQ" name="Partition coefficient (water/container)" description="Partition coefficient Water / Container (will be mapped to concrete container in the simulation)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="U4lXSKDoeUmY6RFvgzNGSw" isDefault="1">
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+                        <Tags>
+                          <Tag value="Saliva" />
+                        </Tags>
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+                        <Children>
+                          <Parameter id="36WtvjpvB0ytFgAZONmrxw" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="_5AQF4X5mkuTWnIB24ghvw" isDefault="1" displayUnit="µmol/l">
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+                        </Children>
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+                    <Tags>
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+                      <Parameter id="Xx8RqWsVEEi7WoRk45hWdQ" name="Volume" description="Volume of organ or compartment" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" formula="OIJCQWhMx0mSRoq8ZLSdfA" isDefault="1" displayUnit="l">
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+                          <Parameter id="GWgtoNgSaEC_nVCwcVuxuA" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="_5AQF4X5mkuTWnIB24ghvw" isDefault="1" displayUnit="µmol/l">
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+          <Container id="pxXooitF8ESBq-mTk3M0Mg" name="Events" description="Parent container for all non-application events" mode="Logical" containerType="Other" />
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+                <Tags>
+                  <Tag value="Neighborhood: BloodCells / BloodCells" />
+                </Tags>
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+                  <Container id="C719b8Qbzk2AT_EDEWof8A" name="Aciclovir" mode="Logical" containerType="Molecule">
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+                <Tags>
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+                      <Tag value="Neighborhood: Plasma / BloodCells" />
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+                <Tags>
+                  <Tag value="Neighborhood: Plasma / BloodCells" />
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+                  <Parameter id="QZQ-lzCzaUiLrtXY8gO4AQ" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="uaERCpR8zkmWXD5h-K2nPg" isDefault="1" displayUnit="cm²">
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+                <Tags>
+                  <Tag value="Neighborhood: BloodCells / BloodCells" />
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+                  <Container id="Acsl1UG4-E-7_8pQHBC9Wg" name="Aciclovir" mode="Logical" containerType="Molecule">
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+                <Tags>
+                  <Tag value="Neighborhood: Interstitial / Intracellular" />
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+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="78" />
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+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="76" />
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+                      <Parameter id="cEYRxqUp4UOUXHnK5vZYxQ" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="M2WXUlVpY0W18PhhdNB88Q" isDefault="1" displayUnit="l/min">
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+                      <Parameter id="8vHAiKgl-U-_8FZUgCg-mw" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="70Te4TWLFEi68KKWZ6BTqA" isDefault="1" displayUnit="l/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
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+                      <Parameter id="xUfz6PTbHE6vUadTzBWlFA" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
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+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
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+                </Children>
+              </Neighborhood>
+              <Neighborhood id="nOwElCRSTE6L8TdpQEYDXQ" name="Bone_pls_Bone_int" description="Neighborhood between Bone/Plasma and Bone/Interstitial" mode="Logical" containerType="Neighborhood" firstNeighbor="XIexKncboU6oimL2fajUaQ" secondNeighbor="QBUx9bH5y06GCUzGSeKCLw">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / Interstitial" />
+                </Tags>
+                <Children>
+                  <Container id="4ww3asqrskifIOgplAq7Iw" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="pkJ9J3rTGEGRAV5lKDeD5A" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
+                        <ValueOrigin id="49" source="Other" method="Assumption" description="Assumption: very fast exchange" />
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="77" />
+                      </Parameter>
+                      <Parameter id="MaRF8zcAUkeH5B3ViCmKhA" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="WO-8Vog5vUuNvOpjrIOoOg" isDefault="1">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="70" />
+                      </Parameter>
+                      <Transport id="tLm7hK5Ve0-F0e8RMeRNcA" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Transport" dimension="Amount per time" formula="qb9nM4022Ua9vyQI7z5FMQ" sourceAmount="TGkDx4tZT0ypmP-gEA4AuA" targetAmount="kpPnx5In4Em3nHuoD25U8g" />
+                    </Children>
+                  </Container>
+                  <Parameter id="IvuF3P1ATUChmVw3R6ePPw" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="AZkggjdUl0aYrfLaJcnDWw" isDefault="1" displayUnit="cm²">
+                    <Tags>
+                      <Tag value="Neighborhood: Plasma / Interstitial" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="1" ref="0" bb="32" group="106" />
+                  </Parameter>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="6tBNk2tYZkaDhcddV5KAwg" name="Bone_pls_VenousBlood_pls" description="Neighborhood between Bone/Plasma and Venous Blood/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="XIexKncboU6oimL2fajUaQ" secondNeighbor="7Skx_VpY1kGT74Rns_5puw">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / Plasma" />
+                </Tags>
+                <Children>
+                  <Container id="6S7XIrXdAkmD8qrZyjlO0Q" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="BO9hkr_UGECEiQXxDEHCxQ" name="MassTransferOrgPl2BloodPool" description="Mass transfer from organ: Plasma to Venous Blood: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="bmdjC5sInEu_n9pF6g6hEQ" sourceAmount="TGkDx4tZT0ypmP-gEA4AuA" targetAmount="7Rbeovs3_k-ueQGXqYkAXw" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="OPT3_7jkOUqQIw2aY-1tWw" name="Brain_bc_VenousBlood_bc" description="Neighborhood between Brain/Blood Cells and Venous Blood/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="ZZ7zER2x_UqPUjGeqMMoNA" secondNeighbor="9pDSL8Nq0US2M-Z4-4NiNw">
+                <Tags>
+                  <Tag value="Neighborhood: BloodCells / BloodCells" />
+                </Tags>
+                <Children>
+                  <Container id="tuOntrmM20Snmh2sUM-WsQ" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="VbQq3sD2oEC1kcbiZW4kFQ" name="MassTransferOrgRBC2BloodPool" description="Mass transfer from organ: Blood Cells to Arterial Blood: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="DCmhjW5Xm0mYALA5BXvXpg" sourceAmount="XTM3f4NFL0OOb4D7deYV6g" targetAmount="C5df-rtR9kqsgkV4ZWZUKg" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="jo3C0q1EtkqlsEtT2bTkUw" name="Brain_int_Brain_cell" description="Neighborhood between Brain/Interstitial and Brain/Intracellular" mode="Logical" containerType="Neighborhood" firstNeighbor="FrP8e0_vP0-5LHOlQGtnwg" secondNeighbor="q0HNcFDmC0izgpK1GxDEoA">
+                <Tags>
+                  <Tag value="Neighborhood: Interstitial / Intracellular" />
+                </Tags>
+                <Children>
+                  <Container id="dDzk9xfqe0aY59ABgU5QYA" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="O1sBWPLWGkG2WMWYwRhsHw" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="iF9O5xA_e0SIVFmFG1ht8A" isDefault="1" displayUnit="cm/min">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="78" />
+                      </Parameter>
+                      <Parameter id="iVOTdUqAKEKa7hbcg2TXbQ" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="IKrcjT7b50S-hZpXm7B5cQ" isDefault="1" displayUnit="cm/min">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="76" />
+                      </Parameter>
+                      <Parameter id="bXghjM_JVUunU-W-5AQe-w" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="M2WXUlVpY0W18PhhdNB88Q" isDefault="1" displayUnit="l/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="RpR5rksq2E-4gxphnguq6A" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="70Te4TWLFEi68KKWZ6BTqA" isDefault="1" displayUnit="l/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="bdmL01dQRESTyM5LrZYqjQ" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="dh7ogco1lkyB5yrvyj0Onw" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="dJqsH2zfiEOrkkSKLeDWMg" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="8UM55Zd-L0ShxbxvftoUAA" isDefault="1">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="69" />
+                      </Parameter>
+                      <Parameter id="5VT-VZ6nPEeVip7aSXjqlA" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cf5OHy-pE0-BjjqyfS_nTg" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+                      </Parameter>
+                      <Parameter id="6ZlBM2wv10mdZ5-7PiHMAQ" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Bt_w0lgTQUaqAN1PGNzfMg" isDefault="1">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Transport id="52XN3qTEpU2VGCj5tmCbxA" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Transport" dimension="Amount per time" formula="KAbFyL-ddEmHhvi-bCu0vA" sourceAmount="cRtORJFyfESm0hU73qLoaQ" targetAmount="S5-WmtTdbk6h03nBqo-LSQ" />
+                    </Children>
+                  </Container>
+                  <Parameter id="AxBoDf4unkGXpxyQBhy2IA" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="q1KW-AMk506AOOq7NSJj0Q" isDefault="1" displayUnit="cm²">
+                    <Tags>
+                      <Tag value="Neighborhood: Interstitial / Intracellular" />
+                    </Tags>
+                    <Info min="0" flag="122" seq="2" ref="0" bb="32" group="105" />
+                  </Parameter>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="0nBcCnnD6kKQwkkOGDP7lA" name="Brain_pls_Brain_bc" description="Neighborhood between Brain/Plasma and Brain/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="6o29eHLmlky4_L3eSRa9CQ" secondNeighbor="ZZ7zER2x_UqPUjGeqMMoNA">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / BloodCells" />
+                </Tags>
+                <Children>
+                  <Container id="KERcPGqUlkqr3Tfar2lqvA" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="EoFV_HBSakWPLmRfH56hGA" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="gtVPllQBtE-PYpfdnpcjrg" sourceAmount="QK7_wktim0CrMDuiwvhqLw" targetAmount="XTM3f4NFL0OOb4D7deYV6g" />
+                    </Children>
+                  </Container>
+                  <Parameter id="nShpEct84EiYUKYTv2it4Q" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="igOBRcAVbUC8WRlGY5a2LQ" isDefault="1" displayUnit="cm²">
+                    <Tags>
+                      <Tag value="Neighborhood: Plasma / BloodCells" />
+                    </Tags>
+                    <Info min="0" flag="122" seq="4" ref="0" bb="32" group="104" />
+                  </Parameter>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="m6EW-5PBXkad-7y4UcMgFQ" name="Brain_pls_Brain_int" description="Neighborhood between Brain/Plasma and Brain/Interstitial" mode="Logical" containerType="Neighborhood" firstNeighbor="6o29eHLmlky4_L3eSRa9CQ" secondNeighbor="FrP8e0_vP0-5LHOlQGtnwg">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / Interstitial" />
+                </Tags>
+                <Children>
+                  <Container id="ZMF-D7QOCUG4SFjBQJs6tA" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="YPTa82S00EiFN1LrehAKWQ" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="dg5NX0A-B0KIkml-_CfGfg" isDefault="1" displayUnit="cm/min">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="77" />
+                      </Parameter>
+                      <Parameter id="AmykgLDmZk6uru0ByBU-nQ" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="WO-8Vog5vUuNvOpjrIOoOg" isDefault="1">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="70" />
+                      </Parameter>
+                      <Transport id="9yZ20C3ID0Ky8wAVSGGINw" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Transport" dimension="Amount per time" formula="qr4ygZr8MEuT6LL4pAB2uA" sourceAmount="QK7_wktim0CrMDuiwvhqLw" targetAmount="cRtORJFyfESm0hU73qLoaQ" />
+                    </Children>
+                  </Container>
+                  <Parameter id="DSp7yxh0mkqrlxj0xkk3ug" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="cCRaXBSvJkW51VJBYeCkCw" isDefault="1" displayUnit="cm²">
+                    <Tags>
+                      <Tag value="Neighborhood: Plasma / Interstitial" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="2" ref="0" bb="32" group="106" />
+                  </Parameter>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="lP4i6SgHnUKbaRnYXRp3hw" name="Brain_pls_VenousBlood_pls" description="Neighborhood between Brain/Plasma and Venous Blood/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="6o29eHLmlky4_L3eSRa9CQ" secondNeighbor="7Skx_VpY1kGT74Rns_5puw">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / Plasma" />
+                </Tags>
+                <Children>
+                  <Container id="Y6p7m_VD7Uy2Mx8x6RHujg" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="fFeX4nZGjUSXkz4ZRiD5Hw" name="MassTransferOrgPl2BloodPool" description="Mass transfer from organ: Plasma to Venous Blood: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="GWXY8GNdGEinDtHwz8ZERw" sourceAmount="QK7_wktim0CrMDuiwvhqLw" targetAmount="7Rbeovs3_k-ueQGXqYkAXw" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="6DBZ9ZlZvkKS2RRLq1dJkg" name="Fat_bc_VenousBlood_bc" description="Neighborhood between Fat/Blood Cells and Venous Blood/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="NZxOvgCsl0KK1TCHgZbMYg" secondNeighbor="9pDSL8Nq0US2M-Z4-4NiNw">
+                <Tags>
+                  <Tag value="Neighborhood: BloodCells / BloodCells" />
+                </Tags>
+                <Children>
+                  <Container id="YEjVkwH_3UGCGifDXl1kyQ" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="rDS61R2FAUGON9D0Gt-5ow" name="MassTransferOrgRBC2BloodPool" description="Mass transfer from organ: Blood Cells to Arterial Blood: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="xVJRrfz3vUGG-eKaPDq1Ag" sourceAmount="VyJX6uklU0KkdB4Y0-tVow" targetAmount="C5df-rtR9kqsgkV4ZWZUKg" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="W76tprXNd0WullpqXurGag" name="Fat_int_Fat_cell" description="Neighborhood between Fat/Interstitial and Fat/Intracellular" mode="Logical" containerType="Neighborhood" firstNeighbor="tFhmVZNGKUi05kjP3IMsHQ" secondNeighbor="vSG3Se6VokOfPMnJgaNt6g">
+                <Tags>
+                  <Tag value="Neighborhood: Interstitial / Intracellular" />
+                </Tags>
+                <Children>
+                  <Container id="dv20VL8ukEOsdrfp6Ah1dg" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="0zsUsq55FUG4_nEmuB4e_A" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="iF9O5xA_e0SIVFmFG1ht8A" isDefault="1" displayUnit="cm/min">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="78" />
+                      </Parameter>
+                      <Parameter id="sVpWnOTYl0GJW1ygTqkmaw" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="IKrcjT7b50S-hZpXm7B5cQ" isDefault="1" displayUnit="cm/min">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="76" />
+                      </Parameter>
+                      <Parameter id="NacDZwouS0yE0CVJAotLJA" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="M2WXUlVpY0W18PhhdNB88Q" isDefault="1" displayUnit="l/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="26EVbwB1A0270vITgaABOw" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="70Te4TWLFEi68KKWZ6BTqA" isDefault="1" displayUnit="l/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="RxJi6UukeUC_UYlPQZzPhw" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="h8nTt45nDUau9fTTX7kbOg" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="uOrIJZCxjU-v3rTAHeKuTg" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TMa39_XQVUmzkgEe3pscJg" isDefault="1">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="69" />
+                      </Parameter>
+                      <Parameter id="wwXyPhXoiUyX44TlgSr22Q" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cf5OHy-pE0-BjjqyfS_nTg" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+                      </Parameter>
+                      <Parameter id="ZxWaGnDNoUGhLPrZ5rABHw" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="PsxrRyft1kiC4xCIn4gmtg" isDefault="1">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Transport id="_-EBfRHYZ0uEvGaGYHiQKg" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Transport" dimension="Amount per time" formula="ilUhF7v4iUasiFeo8MdAZg" sourceAmount="MO350Jid4Uy-RDivvJCeAg" targetAmount="B5UZeYaVIU26mxhCdDiJUQ" />
+                    </Children>
+                  </Container>
+                  <Parameter id="qZ9wyTaX00GIsIQFyXJjuQ" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="_b9eqYLG70-Cj6hBgpkiyg" isDefault="1" displayUnit="cm²">
+                    <Tags>
+                      <Tag value="Neighborhood: Interstitial / Intracellular" />
+                    </Tags>
+                    <Info min="0" flag="122" seq="3" ref="0" bb="32" group="105" />
+                  </Parameter>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="j-nenLFhckyqZ5ls18M-DA" name="Fat_pls_Fat_bc" description="Neighborhood between Fat/Plasma and Fat/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="jJKX8FGI-UO3bnlzFyUdjw" secondNeighbor="NZxOvgCsl0KK1TCHgZbMYg">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / BloodCells" />
+                </Tags>
+                <Children>
+                  <Container id="Coe_yLFY3k6xa-Yfjja9VQ" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="wqlAx9z1mE6K0ERXW9RKpw" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="bXuSaM2YckG7ER-LG9PL_w" sourceAmount="clnPhL5JykSeqIuCVtRsRg" targetAmount="VyJX6uklU0KkdB4Y0-tVow" />
+                    </Children>
+                  </Container>
+                  <Parameter id="MB0FTEDksUKJqcxn98XUzw" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="8npinDgvQUiGPufPlHvZ8g" isDefault="1" displayUnit="cm²">
+                    <Tags>
+                      <Tag value="Neighborhood: Plasma / BloodCells" />
+                    </Tags>
+                    <Info min="0" flag="122" seq="5" ref="0" bb="32" group="104" />
+                  </Parameter>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="6ntXKpXwxkqyQDjF6yePSQ" name="Fat_pls_Fat_int" description="Neighborhood between Fat/Plasma and Fat/Interstitial" mode="Logical" containerType="Neighborhood" firstNeighbor="jJKX8FGI-UO3bnlzFyUdjw" secondNeighbor="tFhmVZNGKUi05kjP3IMsHQ">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / Interstitial" />
+                </Tags>
+                <Children>
+                  <Container id="7EkPyxXtMkylFtfZ87uYEg" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="8kmOcfxlqUW0V-KUZ9bCsQ" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
+                        <ValueOrigin id="49" source="Other" method="Assumption" description="Assumption: very fast exchange" />
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="77" />
+                      </Parameter>
+                      <Parameter id="-4yMm-IINE-vySFDhwandA" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="WO-8Vog5vUuNvOpjrIOoOg" isDefault="1">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="70" />
+                      </Parameter>
+                      <Transport id="YiPeXFXjp06JnWpiKwcKQA" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Transport" dimension="Amount per time" formula="eTevY0fpcEOpi3JcBLLfCw" sourceAmount="clnPhL5JykSeqIuCVtRsRg" targetAmount="MO350Jid4Uy-RDivvJCeAg" />
+                    </Children>
+                  </Container>
+                  <Parameter id="KZ_t0qqU6EuvoA8ZlCED9Q" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="1nlroyXAMkSY8eLirfpD5Q" isDefault="1" displayUnit="cm²">
+                    <Tags>
+                      <Tag value="Neighborhood: Plasma / Interstitial" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="3" ref="0" bb="32" group="106" />
+                  </Parameter>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="xMsh2Ysc6kyYA1HGvjr2dQ" name="Fat_pls_VenousBlood_pls" description="Neighborhood between Fat/Plasma and Venous Blood/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="jJKX8FGI-UO3bnlzFyUdjw" secondNeighbor="7Skx_VpY1kGT74Rns_5puw">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / Plasma" />
+                </Tags>
+                <Children>
+                  <Container id="h46kKmN0WUqnQT25PX8gwg" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="g7y2GOaljU6FjGIFk5k_FQ" name="MassTransferOrgPl2BloodPool" description="Mass transfer from organ: Plasma to Venous Blood: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="8-xYgRlNFE62XpdPObhMHg" sourceAmount="clnPhL5JykSeqIuCVtRsRg" targetAmount="7Rbeovs3_k-ueQGXqYkAXw" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="vYYWRyRXhkO7bXAlCHD7-Q" name="Gonads_bc_VenousBlood_bc" description="Neighborhood between Gonads/Blood Cells and Venous Blood/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="gC60yfPKTkqclHndWv0AHA" secondNeighbor="9pDSL8Nq0US2M-Z4-4NiNw">
+                <Tags>
+                  <Tag value="Neighborhood: BloodCells / BloodCells" />
+                </Tags>
+                <Children>
+                  <Container id="SYZwSqPtQUSclqypV8OxcA" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="UMOEK_s8fU-ukuG1223s2Q" name="MassTransferOrgRBC2BloodPool" description="Mass transfer from organ: Blood Cells to Arterial Blood: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="aPAneJLiZ0W1CuX5N2XJwA" sourceAmount="LSqLfNMDVk2WXiC6nghR2g" targetAmount="C5df-rtR9kqsgkV4ZWZUKg" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="ehxpV-sgx0eeXUUSBJMoyQ" name="Gonads_int_Gonads_cell" description="Neighborhood between Gonads/Interstitial and Gonads/Intracellular" mode="Logical" containerType="Neighborhood" firstNeighbor="gCx4yXu25EWo4xyIcD309Q" secondNeighbor="DdZ8V2vk90eUwP6IAPU-YA">
+                <Tags>
+                  <Tag value="Neighborhood: Interstitial / Intracellular" />
+                </Tags>
+                <Children>
+                  <Container id="Kdujd4sIe0OCUyGSUKSQhg" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="U7Wl0sdTh0Gxyg_Dgialjw" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="iF9O5xA_e0SIVFmFG1ht8A" isDefault="1" displayUnit="cm/min">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="78" />
+                      </Parameter>
+                      <Parameter id="4L3LhiW0ekWwsoSfIR6Tuw" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="IKrcjT7b50S-hZpXm7B5cQ" isDefault="1" displayUnit="cm/min">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="76" />
+                      </Parameter>
+                      <Parameter id="fLrUj7RcjkykfQ4YjvQl_A" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="M2WXUlVpY0W18PhhdNB88Q" isDefault="1" displayUnit="l/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="_vhadEXqyUilcLSQf0OQvw" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="70Te4TWLFEi68KKWZ6BTqA" isDefault="1" displayUnit="l/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="JJmO2tvVr0WxnihKiIRr8Q" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="v4-jl12dsE-AX2_gXXgRcg" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="vsfJeKsiJkqR5_YYF4j_NQ" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="zN9nmo0TiU-qXqnd2l016A" isDefault="1">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="69" />
+                      </Parameter>
+                      <Parameter id="3xdrKbssmEGpVqUez_VRDw" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cf5OHy-pE0-BjjqyfS_nTg" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+                      </Parameter>
+                      <Parameter id="ZNwEIGZB5UuKJuAoicxPJQ" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_4EoA4HP506lpWplql2e8w" isDefault="1">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Transport id="Fg6T2bALF0iiNd8o1kAbiA" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Transport" dimension="Amount per time" formula="SR7_-1N5eEWAFJM9aAR32Q" sourceAmount="FW3VSauf_0a0Erf3SlS-CQ" targetAmount="bD9BMRqXf0CQzvuU1-iHbg" />
+                    </Children>
+                  </Container>
+                  <Parameter id="_COIGr5FRUeWrwlFH1Xu_A" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="ZhwcUiuAc0WSJWKXpATQig" isDefault="1" displayUnit="cm²">
+                    <Tags>
+                      <Tag value="Neighborhood: Interstitial / Intracellular" />
+                    </Tags>
+                    <Info min="0" flag="122" seq="4" ref="0" bb="32" group="105" />
+                  </Parameter>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="5HtIv3QlOUuY4EUbsKvblQ" name="Gonads_pls_Gonads_bc" description="Neighborhood between Gonads/Plasma and Gonads/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="wol6uDYSXEC0_ZZPDrnoZQ" secondNeighbor="gC60yfPKTkqclHndWv0AHA">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / BloodCells" />
+                </Tags>
+                <Children>
+                  <Container id="MObMsfU3wkqAV5eUdbq4EQ" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="YJYmgvj5UEm9DYgMKmekAA" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="4cKbuxmfHkmJ983J3IpVXw" sourceAmount="mMcNFJzp6EuhC5J9Oc0mGg" targetAmount="LSqLfNMDVk2WXiC6nghR2g" />
+                    </Children>
+                  </Container>
+                  <Parameter id="oG1S94vM_E-Ym59myAsnAw" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="IAwT9O1cOEyQkwNo9MQW_A" isDefault="1" displayUnit="cm²">
+                    <Tags>
+                      <Tag value="Neighborhood: Plasma / BloodCells" />
+                    </Tags>
+                    <Info min="0" flag="122" seq="6" ref="0" bb="32" group="104" />
+                  </Parameter>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="8a7sRvJnBUSZ3dIk3W79mw" name="Gonads_pls_Gonads_int" description="Neighborhood between Gonads/Plasma and Gonads/Interstitial" mode="Logical" containerType="Neighborhood" firstNeighbor="wol6uDYSXEC0_ZZPDrnoZQ" secondNeighbor="gCx4yXu25EWo4xyIcD309Q">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / Interstitial" />
+                </Tags>
+                <Children>
+                  <Container id="BgPQOFARyEe1pVOMP162MQ" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="d6O9dPcXakuwVYySBhBzyA" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
+                        <ValueOrigin id="49" source="Other" method="Assumption" description="Assumption: very fast exchange" />
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="77" />
+                      </Parameter>
+                      <Parameter id="ufkryHlKZ0GDhOt1MoGXig" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="WO-8Vog5vUuNvOpjrIOoOg" isDefault="1">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="70" />
+                      </Parameter>
+                      <Transport id="SlOvfb3-10GBGBcspwMmXw" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Transport" dimension="Amount per time" formula="yOAdiHbmykyw-jz8lZmOKQ" sourceAmount="mMcNFJzp6EuhC5J9Oc0mGg" targetAmount="FW3VSauf_0a0Erf3SlS-CQ" />
+                    </Children>
+                  </Container>
+                  <Parameter id="BfAcOr8P4kut6FJFNokBJA" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="o3IJHolALEqTKGmBuWDLWw" isDefault="1" displayUnit="cm²">
+                    <Tags>
+                      <Tag value="Neighborhood: Plasma / Interstitial" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="4" ref="0" bb="32" group="106" />
+                  </Parameter>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="EfjucIg2L0uCVtXL0gCufw" name="Gonads_pls_VenousBlood_pls" description="Neighborhood between Gonads/Plasma and Venous Blood/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="wol6uDYSXEC0_ZZPDrnoZQ" secondNeighbor="7Skx_VpY1kGT74Rns_5puw">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / Plasma" />
+                </Tags>
+                <Children>
+                  <Container id="12WSNT-KAUOdVtQBLgor2g" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="1zMhk6PR8UGpOR2Ht93a1w" name="MassTransferOrgPl2BloodPool" description="Mass transfer from organ: Plasma to Venous Blood: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="9f3EODjC0Ua_IM1BI4B7wA" sourceAmount="mMcNFJzp6EuhC5J9Oc0mGg" targetAmount="7Rbeovs3_k-ueQGXqYkAXw" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="crXK09ThuUmfKfd3vBXb9Q" name="Heart_bc_VenousBlood_bc" description="Neighborhood between Heart/Blood Cells and Venous Blood/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="25NddIAf-0mKNVC2gSD5nA" secondNeighbor="9pDSL8Nq0US2M-Z4-4NiNw">
+                <Tags>
+                  <Tag value="Neighborhood: BloodCells / BloodCells" />
+                </Tags>
+                <Children>
+                  <Container id="7Xhlia_MkUyiJb3ddJFrVA" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="Lp1BT1BtQUORhjfkjW-mdQ" name="MassTransferOrgRBC2BloodPool" description="Mass transfer from organ: Blood Cells to Arterial Blood: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="PoIO9BddqEeYmA9oIL9mKA" sourceAmount="N9LBQ4qehUmSiJEcITEdVA" targetAmount="C5df-rtR9kqsgkV4ZWZUKg" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="9CkqTqVqN0u5i8-pEbad9Q" name="Heart_int_Heart_cell" description="Neighborhood between Heart/Interstitial and Heart/Intracellular" mode="Logical" containerType="Neighborhood" firstNeighbor="p7-A2Vbx1UiEVIy_3qmPSw" secondNeighbor="0qusEn4MhEyCO9ACWRzPbQ">
+                <Tags>
+                  <Tag value="Neighborhood: Interstitial / Intracellular" />
+                </Tags>
+                <Children>
+                  <Container id="u3_sbwDZuEaaCSrVF60GoA" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="0rIXasLJHEuW3C42zCLwOg" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="iF9O5xA_e0SIVFmFG1ht8A" isDefault="1" displayUnit="cm/min">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="78" />
+                      </Parameter>
+                      <Parameter id="KkuKk76EUU-VAORrei_zLQ" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="IKrcjT7b50S-hZpXm7B5cQ" isDefault="1" displayUnit="cm/min">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="76" />
+                      </Parameter>
+                      <Parameter id="ImhRepfHJEiiJAggmHaXow" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="M2WXUlVpY0W18PhhdNB88Q" isDefault="1" displayUnit="l/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="udiU13iRNE-oRqihm1OM8Q" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="70Te4TWLFEi68KKWZ6BTqA" isDefault="1" displayUnit="l/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="8o5oy8CSykqR9JcN-lsCRA" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="6rssL4GvKECmI7pKU9LYOg" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="DVtwrnAhPUmtuToutYXD7A" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="zVbNhVTmZEKfGXUZBeFk1A" isDefault="1">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="69" />
+                      </Parameter>
+                      <Parameter id="qKNrORLbHUuPsmpu65allA" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cf5OHy-pE0-BjjqyfS_nTg" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+                      </Parameter>
+                      <Parameter id="Vl672s3OkkSQANngX5mXCQ" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="mN4Z2ONUAEq2IMquh8tkzg" isDefault="1">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Transport id="Vj7oVgEZuEi7gvN3dTSiwg" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Transport" dimension="Amount per time" formula="lkq3mD2M5kyeBDpkf_00HA" sourceAmount="gKyf_CrNI0uajfXR1ROvsA" targetAmount="nrHJsilJf0WCQLHxX7JmZg" />
+                    </Children>
+                  </Container>
+                  <Parameter id="TByar9nCkUOk-f8CLM6-Hg" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="FpyixkNvKEG75O0VxecNrA" isDefault="1" displayUnit="cm²">
+                    <Tags>
+                      <Tag value="Neighborhood: Interstitial / Intracellular" />
+                    </Tags>
+                    <Info min="0" flag="122" seq="5" ref="0" bb="32" group="105" />
+                  </Parameter>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="7xmptWADzUOYr6Zy0bUH6w" name="Heart_pls_Heart_bc" description="Neighborhood between Heart/Plasma and Heart/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="Ql1dRMGROE-Xunwf1NB9cQ" secondNeighbor="25NddIAf-0mKNVC2gSD5nA">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / BloodCells" />
+                </Tags>
+                <Children>
+                  <Container id="nLMBFJWOC0ydcapxEWCmEg" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="rNlHsVyMQUaqhVTMEK3i4A" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="rR9DVLGnpkG5yy-tML9Geg" sourceAmount="XyRpEuOb2kq1o-aKqGsssw" targetAmount="N9LBQ4qehUmSiJEcITEdVA" />
+                    </Children>
+                  </Container>
+                  <Parameter id="bn-1XXbZvESlp-UUmqkuhw" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="b5P94zuDY02htKfnGsWTsA" isDefault="1" displayUnit="cm²">
+                    <Tags>
+                      <Tag value="Neighborhood: Plasma / BloodCells" />
+                    </Tags>
+                    <Info min="0" flag="122" seq="7" ref="0" bb="32" group="104" />
+                  </Parameter>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="6kGILDESbkadaGP084HfUg" name="Heart_pls_Heart_int" description="Neighborhood between Heart/Plasma and Heart/Interstitial" mode="Logical" containerType="Neighborhood" firstNeighbor="Ql1dRMGROE-Xunwf1NB9cQ" secondNeighbor="p7-A2Vbx1UiEVIy_3qmPSw">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / Interstitial" />
+                </Tags>
+                <Children>
+                  <Container id="qnwYYw-HI02Qz7kzQJPGVQ" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="Bm5oTDBcNkufOMA_pj17Qg" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
+                        <ValueOrigin id="49" source="Other" method="Assumption" description="Assumption: very fast exchange" />
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="77" />
+                      </Parameter>
+                      <Parameter id="-DY8R6bmmkCLqUxxdt7QPg" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="WO-8Vog5vUuNvOpjrIOoOg" isDefault="1">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="70" />
+                      </Parameter>
+                      <Transport id="kQFd-DlDa0-SKanVKuiE6g" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Transport" dimension="Amount per time" formula="12uz_x2cT0aCBU8Z6ZiIjg" sourceAmount="XyRpEuOb2kq1o-aKqGsssw" targetAmount="gKyf_CrNI0uajfXR1ROvsA" />
+                    </Children>
+                  </Container>
+                  <Parameter id="p_MPfW8D10ep9TQBTdTC6Q" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="DHR0mxlmcU-Cq-WfBtitcw" isDefault="1" displayUnit="cm²">
+                    <Tags>
+                      <Tag value="Neighborhood: Plasma / Interstitial" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="5" ref="0" bb="32" group="106" />
+                  </Parameter>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="lFPsNqYWO0OIJPLAudO0aQ" name="Heart_pls_VenousBlood_pls" description="Neighborhood between Heart/Plasma and Venous Blood/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="Ql1dRMGROE-Xunwf1NB9cQ" secondNeighbor="7Skx_VpY1kGT74Rns_5puw">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / Plasma" />
+                </Tags>
+                <Children>
+                  <Container id="pfi9dY7Yg0y_hO1E7EfOsg" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="bFq3nS2J5kOA0FVvT8dILQ" name="MassTransferOrgPl2BloodPool" description="Mass transfer from organ: Plasma to Venous Blood: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="CCV-loYpsk6XcW2Gt5U_GA" sourceAmount="XyRpEuOb2kq1o-aKqGsssw" targetAmount="7Rbeovs3_k-ueQGXqYkAXw" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="zjCj7tH9CUGO7jVCrh6J2A" name="Kidney_bc_VenousBlood_bc" description="Neighborhood between Kidney/Blood Cells and Venous Blood/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="bmGYwuq6LESERUPPeoFDew" secondNeighbor="9pDSL8Nq0US2M-Z4-4NiNw">
+                <Tags>
+                  <Tag value="Neighborhood: BloodCells / BloodCells" />
+                </Tags>
+                <Children>
+                  <Container id="KUUbEaXWxk2qZi0rSNBGZg" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="KX8eaZFMF0GKcbL4fsF_Xg" name="MassTransferOrgRBC2BloodPool" description="Mass transfer from organ: Blood Cells to Arterial Blood: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="8dkus6DwfECT3PtCuzdk1g" sourceAmount="b5Rk0ZUhO0SbfQmNBmcpOA" targetAmount="C5df-rtR9kqsgkV4ZWZUKg" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="LqcKT9X9VUSwcSH_XiD5GQ" name="Kidney_int_Kidney_cell" description="Neighborhood between Kidney/Interstitial and Kidney/Intracellular" mode="Logical" containerType="Neighborhood" firstNeighbor="mH1BKd2i-ky13maoWxGPaA" secondNeighbor="XIgXWS5nvEuUHScs50XAIg">
+                <Tags>
+                  <Tag value="Neighborhood: Interstitial / Intracellular" />
+                </Tags>
+                <Children>
+                  <Container id="qek3ODOhpUO_G8NQhVaG8A" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="NTNK2nxTzkGORC5zUOloKA" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="iF9O5xA_e0SIVFmFG1ht8A" isDefault="1" displayUnit="cm/min">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="78" />
+                      </Parameter>
+                      <Parameter id="TF5b6yAK_0SbhXO4595B_w" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="IKrcjT7b50S-hZpXm7B5cQ" isDefault="1" displayUnit="cm/min">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="76" />
+                      </Parameter>
+                      <Parameter id="Ux8KOrGk-EK5VmixCNPGGw" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="M2WXUlVpY0W18PhhdNB88Q" isDefault="1" displayUnit="l/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="3y_1_EmT7kWtSjl0fbsLKA" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="70Te4TWLFEi68KKWZ6BTqA" isDefault="1" displayUnit="l/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="GJBvqICCmEC22twYM7aqqA" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="vhXg9mUY-kydzlTXi6kHgg" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="izW58Mpg50ahBanSKjQdow" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="T5xwf-IXu0mJ38J0lKuHuA" isDefault="1">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="69" />
+                      </Parameter>
+                      <Parameter id="8RSwLVU0IUOyNv_An-X2HA" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cf5OHy-pE0-BjjqyfS_nTg" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+                      </Parameter>
+                      <Parameter id="r2PteTeWykCmD1yvfdoK7g" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="-iwvne2mXUqxG8uwmwVAbw" isDefault="1">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Transport id="SrWeqEQL0Ey99Q1TpeB0Kw" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Transport" dimension="Amount per time" formula="hWMWKdj6lEe7d5BqOpbI3A" sourceAmount="CwXqydK_Ak-0zxY2mjGT0A" targetAmount="KcOnPbhe0kiuiA288hEnpA" />
+                    </Children>
+                  </Container>
+                  <Parameter id="CzI2hKO7O0Sk_tn7BEBOAQ" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="8QuJreAtB06qyWH3mMZ-DA" isDefault="1" displayUnit="cm²">
+                    <Tags>
+                      <Tag value="Neighborhood: Interstitial / Intracellular" />
+                    </Tags>
+                    <Info min="0" flag="122" seq="6" ref="0" bb="32" group="105" />
+                  </Parameter>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="OtOgJzdvA06PrWppjw-XsA" name="Kidney_cell_Kidney_ur" description="Neighborhood between Kidney/Intracellular and Kidney/Urine" mode="Logical" containerType="Neighborhood" firstNeighbor="XIgXWS5nvEuUHScs50XAIg" secondNeighbor="wNpjA5Wk3kObDSynVtwYHA">
+                <Tags>
+                  <Tag value="Neighborhood: Intracellular / Urine" />
+                </Tags>
+                <Children>
+                  <Container id="Hai28Gi_VUGk1bi-fC2cKw" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="sfbb3l2N-0SS4-J2K88VSA" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="vQmYM4UZaUalGxv67PdT3w" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+                      </Parameter>
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="FzBEGxW83Eq_U2qkXBpuZw" name="Kidney_pls_Kidney_bc" description="Neighborhood between Kidney/Plasma and Kidney/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="5HBO78nMlkKNzLDJB1gD3w" secondNeighbor="bmGYwuq6LESERUPPeoFDew">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / BloodCells" />
+                </Tags>
+                <Children>
+                  <Container id="D5jCxi3BN0GadQM4tUQDcw" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="R7ty_K5-ski5DDIGnXMz2Q" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="0ln149d8fkmPkd8HRao1uA" sourceAmount="UIDahFhwD0qylCjxxmdl8g" targetAmount="b5Rk0ZUhO0SbfQmNBmcpOA" />
+                    </Children>
+                  </Container>
+                  <Parameter id="fBF7ceB9O0uki0CvmZrFlA" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="muesGvcRBkyQyPGQ1UjDZw" isDefault="1" displayUnit="cm²">
+                    <Tags>
+                      <Tag value="Neighborhood: Plasma / BloodCells" />
+                    </Tags>
+                    <Info min="0" flag="122" seq="8" ref="0" bb="32" group="104" />
+                  </Parameter>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="x8J9YVFyhUmDnTVzqG04Eg" name="Kidney_pls_Kidney_int" description="Neighborhood between Kidney/Plasma and Kidney/Interstitial" mode="Logical" containerType="Neighborhood" firstNeighbor="5HBO78nMlkKNzLDJB1gD3w" secondNeighbor="mH1BKd2i-ky13maoWxGPaA">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / Interstitial" />
+                </Tags>
+                <Children>
+                  <Container id="96oIUlffo0Cdqa02VJGtVA" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="JkqowpiMck2KAn8LOgH-Sg" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
+                        <ValueOrigin id="49" source="Other" method="Assumption" description="Assumption: very fast exchange" />
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="77" />
+                      </Parameter>
+                      <Parameter id="ze_dyX1510udjxUHagtE8Q" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="WO-8Vog5vUuNvOpjrIOoOg" isDefault="1">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="70" />
+                      </Parameter>
+                      <Transport id="0UTfKJZ6t02M_U1QONOBdg" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Transport" dimension="Amount per time" formula="xgbBImhsoUyiNcTOhzgiWQ" sourceAmount="UIDahFhwD0qylCjxxmdl8g" targetAmount="CwXqydK_Ak-0zxY2mjGT0A" />
+                    </Children>
+                  </Container>
+                  <Parameter id="NSHYzqoM802MAPH-z17LcA" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="fDbSg-B_QUuQqcxyz2WIBg" isDefault="1" displayUnit="cm²">
+                    <Tags>
+                      <Tag value="Neighborhood: Plasma / Interstitial" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="6" ref="0" bb="32" group="106" />
+                  </Parameter>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="2lWrIVhp5ESEE1C3W77KVA" name="Kidney_pls_Kidney_ur" description="Neighborhood between Kidney/Plasma and Kidney/Urine" mode="Logical" containerType="Neighborhood" firstNeighbor="5HBO78nMlkKNzLDJB1gD3w" secondNeighbor="wNpjA5Wk3kObDSynVtwYHA">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / Urine" />
+                </Tags>
+                <Children>
+                  <Container id="VxJjgI7mzUKNeF6aq6595A" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="wGvBWbHicEiiNbE7A5qy7Q" name="Renal Clearances-TS" icon="TubularSecretion" mode="Logical" containerType="Transport" dimension="Amount per time" formula="VlWWvvZzkUCUkGHYSHUycw" sourceAmount="UIDahFhwD0qylCjxxmdl8g" targetAmount="KXfS231q7UW25dVduVvvXA">
+                        <Children>
+                          <Parameter id="UWrRf1vUvUiSGCeTlJWGPQ" name="Volume (kidney)" description="Volume of the kidney" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="0" value="0.4377199853" displayUnit="l">
+                            <ValueOrigin source="Unknown" />
+                            <Info min="0" flag="58" seq="1" ref="0" bb="4" group="130" />
+                          </Parameter>
+                          <Parameter id="9UgPaz4WckSaHF1q4GM4Gg" name="Tubular secretion" description="Intrinsic clearance for tubular secretion" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" isDefault="0" value="0.412" displayUnit="l/min">
+                            <Info min="0" flag="58" seq="2" ref="0" bb="4" group="130" />
+                          </Parameter>
+                          <Parameter id="Zlb0O4Nc0kmb30HDx5gRHA" name="TSspec" description="Specific clearance for tubular secretion" icon="Parameter" persistable="0" isFixedValue="0" dim="Inversed time" quantityType="Parameter" negativeValuesAllowed="1" formula="RTvXy1ziBUmPPDJSVo2JuA" isDefault="1" displayUnit="1/min">
+                            <Info min="0" flag="122" seq="3" ref="0" bb="4" group="131" />
+                          </Parameter>
+                        </Children>
+                      </Transport>
+                      <Transport id="Iasn19AtKUyqn91s1hGUgw" name="Glomerular Filtration-GFR" icon="GlomerularFiltration" mode="Logical" containerType="Transport" dimension="Amount per time" formula="yVVccI634kW__mycpzf-7A" sourceAmount="UIDahFhwD0qylCjxxmdl8g" targetAmount="KXfS231q7UW25dVduVvvXA">
+                        <Children>
+                          <Parameter id="e-lKwEJEz0K2KZyFCmEGGA" name="GFR fraction" description="Fraction of glomerular filtration rate used for passive renal elimination.&#xD;&#xA;GFR fraction should be reduced in the case of:&#xD;&#xA;* actively reabsorbed molecules&#xD;&#xA;* macromolecules" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" isDefault="0" value="1">
+                            <Info min="0" flag="122" seq="1" ref="0" bb="4" group="131" />
+                          </Parameter>
+                        </Children>
+                      </Transport>
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="_9CzA7fY6kGXoAuw_rGQtQ" name="Kidney_pls_VenousBlood_pls" description="Neighborhood between Kidney/Plasma and Venous Blood/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="5HBO78nMlkKNzLDJB1gD3w" secondNeighbor="7Skx_VpY1kGT74Rns_5puw">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / Plasma" />
+                </Tags>
+                <Children>
+                  <Container id="PSywsyWpOka0wrmFt5pMsQ" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="Z_Q-MHOS4kWJ9Tb9MCt1CA" name="MassTransferOrgPl2BloodPool" description="Mass transfer from organ: Plasma to Venous Blood: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="AOVAwAdwbEiD9WElAFxC4A" sourceAmount="UIDahFhwD0qylCjxxmdl8g" targetAmount="7Rbeovs3_k-ueQGXqYkAXw" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="f7TsFJWBhkepdj-a8wRMEg" name="Lumen_uje_UpperJejunum_pls" description="Neighborhood between Lumen/Upper Jejunum and Mucosa/Upper Jejunum/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="Al-BX9A42kuv1-su9wdy3g" secondNeighbor="AdnIgrbZwUCQM9gcoqPNFg">
+                <Tags>
+                  <Tag value="Neighborhood: UpperJejunum / Plasma" />
+                </Tags>
+                <Children>
+                  <Container id="11zHmdUroEStvnJmoP85WA" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="oVmcAk9jDEKIImvIZlN6Ng" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="hd9ReWddokK8fg4WxY2Euw" isDefault="1" displayUnit="µmol/min">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                      </Parameter>
+                      <Parameter id="w3H7hNNKjUuloCsICBe3fA" name="Sum of active process rates" description="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="LB12YK8w1kGvHUJlM99XHQ" isDefault="1" displayUnit="µmol/min">
+                        <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="mJoR0z7VaU2HB_0QssUmjQ" name="Sum of passive process rates" description="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="PMr2Out0SE6DNLnxpzA9cw" isDefault="1" displayUnit="µmol/min">
+                        <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Transport id="rvxMvJ8kzkKAWbcFdwpjRg" name="DrugAbsorption_para" description="Drug absorption paracellular" mode="Logical" containerType="Transport" dimension="Amount per time" formula="-KXY_ox-AkmP7yZgRZn0BA" sourceAmount="CSHZ6BJVOEyAMrV3APtuzA" targetAmount="jXed7RBVDE-arIEOj4e22g">
+                        <Children>
+                          <Parameter id="cSxf1FYNq0C9eRATUOPXdQ" name="ProcessRate" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="-KXY_ox-AkmP7yZgRZn0BA" isDefault="1" displayUnit="µmol/min">
+                            <Tags>
+                              <Tag value="DrugAbsorption_para" />
+                              <Tag value="ProcessRate" />
+                              <Tag value="Aciclovir" />
+                              <Tag value="Lumen_uje_UpperJejunum_pls" />
+                              <Tag value="Passive" />
+                            </Tags>
+                            <Info flag="6" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                        </Children>
+                      </Transport>
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="u3aaMt0u-UW7Y2wHI1nUnA" name="Lumen_uje_UpperJejunum_cell" description="Neighborhood between Lumen/Upper Jejunum and Mucosa/Upper Jejunum/Intracellular" mode="Logical" containerType="Neighborhood" firstNeighbor="Al-BX9A42kuv1-su9wdy3g" secondNeighbor="TQzcOQRzpECL6ftYDxUa4A">
+                <Tags>
+                  <Tag value="Neighborhood: UpperJejunum / Intracellular" />
+                </Tags>
+                <Children>
+                  <Container id="HHnf085bHkWMXcg5Ik1HgA" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="0DSUCR0ZXEWFw12r0C003g" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Xt86Mb38yUKgjUOuPZM6TA" isDefault="1" displayUnit="µmol/min">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                      </Parameter>
+                      <Parameter id="D7OtUB3u4E2-fwKXs8OWjw" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="3y6-m8wgOEKD3GtEjz0zzg" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="pdVUzZDNokuNKtwOK9swZg" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="lJ91Y9prMU-IAOmp8VeUZA" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="8v_8o1m-pU6MGLqlFQg1xw" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="GbQHBevvy0WQRWQ8wyLNzw" isDefault="1">
+                        <Info min="0" flag="36" seq="1" ref="0" bb="2" group="67" />
+                      </Parameter>
+                      <Parameter id="4svlRxWcz0OnsjsIZxyLuA" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="eCY18cJN70ObTfKFkAtU6A" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+                      </Parameter>
+                      <Parameter id="S4Yk3jRu60KDB0QQajSosA" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_kycZRSbGEqrN3v09AAh6Q" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="N-zd1c9h90-_NRd-Ki6WXQ" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="WtWBcizupUq9Qkfy5yle4A" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="76WB8Fgty0GffSwyKEFHtw" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="uocV4bv6Tk6IW5_dlWFeUQ" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="eBGZ7Zb7mEuKZTwIrGcukA" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="lfuixO3kjEW_DgVwm-NEkA" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="TS9wvEsNhUyD4CG9iiZpRQ" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="wpZOWtsCVEivIawZ0cJTQQ" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="-Pu-t6KXikSio7q1OQ3lhQ" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="zDjvv8qD_0q6sFClKz_6Dw" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="PgvpAWQ2y06_6jE_eBoiJw" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IIYsrx_Fhkm3HVhCSgi4JA" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="uwz9jBulp0-UGAV4ZMe7NQ" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="unqtYV5AeEOgOCuJHP2VSA" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="UkGpLo4E0kOgkp56oMpvIw" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="bpZDuWciwU2LDzUNVjrx2A" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="sPOlUnohcUGFe2_k9_pAhg" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="WlVW33RvI0izDWhDdH2ACw" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="XKMCxIQ_W0-OSTsvr9P3tg" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="lZaz3UUV6EeQOunL9WZ4_g" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="4xtfueEFB0yTPRANUhFztA" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Tz1WiOG_k0CPB0dEBzi4mA" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="a64hQta5Ekiais6YJ5i8oQ" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="v4RW1E3qckKuhTvRfKdr3g" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="Xa99gNdPIk-tj7J87tyi-A" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="KZweGiz0DEq_XR3_2wRweA" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="SH4vzBW_4EKPpGJD3N34Qw" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="5JG_BBjIek6qnerxqqbp5A" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="acnLkq0F9ECTgBz1Xbg2gg" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="9Avqn_lfmkOYWTl8-_rMmg" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="gaHtqP7tEUiV7KBLazjneA" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ucHi0vXPN0WPpok-4cCWCQ" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="DIHOdobW0kiIk5zO_9VwJg" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Q7JAceEGmkCCiLcIdSgVFg" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="irRvkP7rzk2DxDr1UPwyiw" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cg3-HM5rEkyKAe6nt4Tgnw" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="fR5AUdu0J0GW_RQQRkJboQ" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="rI_XOwPh-kSUkyS48tdLCw" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="PpoquDs6A0etl1a1bbw1Ow" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="2MsqcDgQ9kWp8tSdr6OMJQ" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="VpWgVN0tlk6oh_xzIeRgZA" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="fRQlUllt4kGqcKWlmlGP7g" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="coLL6qSYOUKCPF86c1s6ug" name="Sum of active process rates" description="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="i1VFtzIgcUmh8uFZfnpx9Q" isDefault="1" displayUnit="µmol/min">
+                        <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="mH8HzfUiokWHgecZiL2zSA" name="Sum of passive process rates" description="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="g3T2G4W-b0acl6Fx_pdFpg" isDefault="1" displayUnit="µmol/min">
+                        <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Transport id="l28aux9mp0aIWqZjYt4xNg" name="DrugAbsorption_trans" description="Drug absorption transcellular" mode="Logical" containerType="Transport" dimension="Amount per time" formula="3JMB9TjaN0Wvy22WxVrHIA" sourceAmount="CSHZ6BJVOEyAMrV3APtuzA" targetAmount="1JhFILMnCkmu_eod-U80pA">
+                        <Children>
+                          <Parameter id="y6CUytIB0UCz7oe0-yIQnQ" name="ProcessRate" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="3JMB9TjaN0Wvy22WxVrHIA" isDefault="1" displayUnit="µmol/min">
+                            <Tags>
+                              <Tag value="DrugAbsorption_trans" />
+                              <Tag value="ProcessRate" />
+                              <Tag value="Aciclovir" />
+                              <Tag value="Lumen_uje_UpperJejunum_cell" />
+                              <Tag value="Passive" />
+                            </Tags>
+                            <Info flag="6" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                        </Children>
+                      </Transport>
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="B9HHeeXJPUOvwDCMecBOvQ" name="UpperJejunum_pls_PortalVein_pls" description="Neighborhood between Upper Jejunum/Plasma and PortalVein/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="AdnIgrbZwUCQM9gcoqPNFg" secondNeighbor="s_QiQGLN10Omt7YLmTFwjg">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / Plasma" />
+                </Tags>
+                <Children>
+                  <Container id="XHqteVLSgkqNv8rACpK9Gg" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="L3br9jYxykOL4cemUXqGtA" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Z7aaQ6H-qk2jEawI3bbneg" isDefault="1" displayUnit="µmol/min">
+                        <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                      </Parameter>
+                      <Transport id="YvybzRfVy06pIlJwqrmwOA" name="MassTransferMucosaToPvePlasma" description="Mass transfer from Mucosa:Plasma To Portal Vein: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="oMa8K2QFjkqDvwxNdjWyfQ" sourceAmount="jXed7RBVDE-arIEOj4e22g" targetAmount="JvJXBdwv-UOGE6DoopBJuA" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="nWVGUhWY5USDHKeSqqpf0w" name="UpperJejunum_bc_PortalVein_bc" description="Neighborhood between Upper Jejunum/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="Gu_kquVcG0O_zuSeiO8r4Q" secondNeighbor="-iUsllv1MkOvPkSoihwHiA">
+                <Tags>
+                  <Tag value="Neighborhood: BloodCells / BloodCells" />
+                </Tags>
+                <Children>
+                  <Container id="dh_MAivd_kGQiXaAZlg9HA" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="jmO3bU0hm06K6tegIT0qJA" name="Mass transfer rate (mucosa to portal vein blood cells)" description="Mass transfer rate (mucosa to portal vein blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="qumhahiG30K2lLuwBSNj_g" isDefault="1" displayUnit="µmol/min">
+                        <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                      </Parameter>
+                      <Transport id="OaFFVC7Mj0q-MqPIGUaSSw" name="MassTransferMucosaToPveBC" description="Mass transfer from Mucosa:Blood Cells To Portal Vein: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="B86fXDx4ek6esZdCQa8BqQ" sourceAmount="_8TJYo65bE2WdF0w6RPdjQ" targetAmount="RCAqJaBNgE-vkuaKfPZpnw" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="5BlqUBE68kurObrsRBlfXA" name="Lumen_lje_LowerJejunum_pls" description="Neighborhood between Lumen/Lower Jejunum and Mucosa/Lower Jejunum/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="fitLwZdQGUqPqO1eHGEd4A" secondNeighbor="UFlatkQIoEK5k-bXY6FG-Q">
+                <Tags>
+                  <Tag value="Neighborhood: LowerJejunum / Plasma" />
+                </Tags>
+                <Children>
+                  <Container id="usOI6arkfkqbcx8q6Iwv_w" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="03GCegn370G-Zi4uhTfgIQ" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="n4BntrQjb0Gnw3GTIRkqvw" isDefault="1" displayUnit="µmol/min">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                      </Parameter>
+                      <Parameter id="BgXioo7zl02CYi8bLh0usg" name="Sum of active process rates" description="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="KyNAuEClpUCKQj_xXK22Lw" isDefault="1" displayUnit="µmol/min">
+                        <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="GqtT8N-KhE-lYDUYqjmxsg" name="Sum of passive process rates" description="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="h86cwVWoY02SylaodooiDg" isDefault="1" displayUnit="µmol/min">
+                        <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Transport id="5CURLT7H-E6t1WzSM77vGg" name="DrugAbsorption_para" description="Drug absorption paracellular" mode="Logical" containerType="Transport" dimension="Amount per time" formula="s8oXgplP3kyMz5_j24gwKw" sourceAmount="PAqF1HO7pkuY5X-5OikQTw" targetAmount="MFQ1DjGCz0GYLNDQI5iUVg">
+                        <Children>
+                          <Parameter id="zKnYOhDcrEyhJwIFWBYZ6w" name="ProcessRate" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="yRtxUVqETU-N4_pvuqDnDw" isDefault="1" displayUnit="µmol/min">
+                            <Tags>
+                              <Tag value="DrugAbsorption_para" />
+                              <Tag value="ProcessRate" />
+                              <Tag value="Aciclovir" />
+                              <Tag value="Lumen_lje_LowerJejunum_pls" />
+                              <Tag value="Passive" />
+                            </Tags>
+                            <Info flag="6" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                        </Children>
+                      </Transport>
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="ZEbRZ6UqvUGuMYpPf66BFA" name="Lumen_lje_LowerJejunum_cell" description="Neighborhood between Lumen/Lower Jejunum and Mucosa/Lower Jejunum/Intracellular" mode="Logical" containerType="Neighborhood" firstNeighbor="fitLwZdQGUqPqO1eHGEd4A" secondNeighbor="LMUmav6ZqUmNU0OFAGoySg">
+                <Tags>
+                  <Tag value="Neighborhood: LowerJejunum / Intracellular" />
+                </Tags>
+                <Children>
+                  <Container id="NRmlTagum0urYdmoEYuKJA" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="Rmk1Ga4IM0GboUL8B5aopQ" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="COoQsAd5pEm7sEaj3OQ_uA" isDefault="1" displayUnit="µmol/min">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                      </Parameter>
+                      <Parameter id="ag0IFv0KBEi9WT4SZcrayQ" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="3y6-m8wgOEKD3GtEjz0zzg" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="pt5pGIeP80Obv_Bo2yvLlw" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="lJ91Y9prMU-IAOmp8VeUZA" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="HqYQo7DyUkSeODYBHRTIJQ" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="oIdvPiB-J0ejVXHKaMMjog" isDefault="1">
+                        <Info min="0" flag="36" seq="1" ref="0" bb="2" group="67" />
+                      </Parameter>
+                      <Parameter id="YgtvFbGOiEG-rTH-D_SSRA" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="GADKfOtOk025g6RzaaxEgA" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+                      </Parameter>
+                      <Parameter id="ImZlu7QtJ0iekMsdEvJ2pg" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="7IphMZleEEWG8e-CF7uMbQ" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="kg9KP7iliUmAjmpg7y5dYQ" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="iDotmI2HF02q4wcG2B14lg" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="YePQxE-t9UCNggosL8bdLQ" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TZ_tc4xk2Ea6HurM_ht0LQ" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="ViIW6TWDE0G1a-boqE4M0Q" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="lfuixO3kjEW_DgVwm-NEkA" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="FDgkWDqoikCSYvkZI4727g" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="wpZOWtsCVEivIawZ0cJTQQ" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="g4-3TBgVVEel5ESCmk4jOQ" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="zDjvv8qD_0q6sFClKz_6Dw" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="BH1WGdOVQEOGUvJbSfHcsA" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IIYsrx_Fhkm3HVhCSgi4JA" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="xPfDdShlHkydjLH1YW60ZQ" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="unqtYV5AeEOgOCuJHP2VSA" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="vqNPmnCZVkScJDftNkVoeA" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="bpZDuWciwU2LDzUNVjrx2A" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="0rQyogjrcku1_H7WquOwAA" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="WlVW33RvI0izDWhDdH2ACw" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="NTs5JiGhIUmAI1cT9rdZvA" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="lZaz3UUV6EeQOunL9WZ4_g" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="z5Ezrs_a9UKRkvAnF4OANA" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="D7J_xdnPXUWOeD0U2LS7jw" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="Fp5aPvDA80qcTyFcvln04Q" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="HJxoNUUODka_0hULggJ_DQ" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="A1AkZqjib06k5RjPeYebvw" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="hQRzaYpwy0C7b_D1cO-isw" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="zaAGay2cB0Sy1qzKdEG8Qw" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="5JG_BBjIek6qnerxqqbp5A" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="SmsqF949KEC5t-_WX6nA5g" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="9Avqn_lfmkOYWTl8-_rMmg" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="dNm5lpzv2keOjMmuNMhwHQ" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ucHi0vXPN0WPpok-4cCWCQ" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="oIpk1wWHPECAR9DfQqTx2g" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Q7JAceEGmkCCiLcIdSgVFg" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="YbGpafDNcUS6VKaJi91yRg" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cg3-HM5rEkyKAe6nt4Tgnw" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="ILCQ14pRykCrID2OKRu-4A" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="rI_XOwPh-kSUkyS48tdLCw" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="pCGDZeTR8Um2IyG8wKJUNw" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="2MsqcDgQ9kWp8tSdr6OMJQ" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="Y-cFrL7OR0av533BY16oaA" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="fRQlUllt4kGqcKWlmlGP7g" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="pCkIyDB80USZ2DqiHL2QCA" name="Sum of active process rates" description="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="VQN0xm6kV0eei-3LfWRgKQ" isDefault="1" displayUnit="µmol/min">
+                        <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="Ec1oq7_xsE-OnmbQluUT9g" name="Sum of passive process rates" description="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="cm8TjWiOz0CXwUY6X0P8fg" isDefault="1" displayUnit="µmol/min">
+                        <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Transport id="9SkoU7e4R0yQM7zdjQ3OoQ" name="DrugAbsorption_trans" description="Drug absorption transcellular" mode="Logical" containerType="Transport" dimension="Amount per time" formula="97TVeMgxSEei-6IXJlaRVQ" sourceAmount="PAqF1HO7pkuY5X-5OikQTw" targetAmount="X63NpTl_LEiYK284w5QvOQ">
+                        <Children>
+                          <Parameter id="DsTnM4cSAkSQAYVeHN7fpA" name="ProcessRate" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="jClV_1IwiECfmwnxlZYKJQ" isDefault="1" displayUnit="µmol/min">
+                            <Tags>
+                              <Tag value="DrugAbsorption_trans" />
+                              <Tag value="ProcessRate" />
+                              <Tag value="Aciclovir" />
+                              <Tag value="Lumen_lje_LowerJejunum_cell" />
+                              <Tag value="Passive" />
+                            </Tags>
+                            <Info flag="6" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                        </Children>
+                      </Transport>
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="w2o6MSaq20WDW6ml60Vv6w" name="LowerJejunum_pls_PortalVein_pls" description="Neighborhood between Lower Jejunum/Plasma and PortalVein/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="UFlatkQIoEK5k-bXY6FG-Q" secondNeighbor="s_QiQGLN10Omt7YLmTFwjg">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / Plasma" />
+                </Tags>
+                <Children>
+                  <Container id="iGPfMHyJpkCQXzp3Fr9oOA" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="KGKsYfEmfkCSrVniZZO_xQ" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="ZL6jNTYgTUiczD6hMOgZSg" isDefault="1" displayUnit="µmol/min">
+                        <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                      </Parameter>
+                      <Transport id="ExYi5yT3J06uWx7WogDHsw" name="MassTransferMucosaToPvePlasma" description="Mass transfer from Mucosa:Plasma To Portal Vein: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="SLRtqC1q3kKBuocmn7UCZw" sourceAmount="MFQ1DjGCz0GYLNDQI5iUVg" targetAmount="JvJXBdwv-UOGE6DoopBJuA" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="hx6qUHMkuUGE--vX_4OKJA" name="LowerJejunum_bc_PortalVein_bc" description="Neighborhood between Lower Jejunum/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="yDYh6-IkUEWuusihzT3Z-g" secondNeighbor="-iUsllv1MkOvPkSoihwHiA">
+                <Tags>
+                  <Tag value="Neighborhood: BloodCells / BloodCells" />
+                </Tags>
+                <Children>
+                  <Container id="yFcYo0AkyESJn9H2skhcYQ" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="T82zgd8tbUSKE4k3DVJwig" name="Mass transfer rate (mucosa to portal vein blood cells)" description="Mass transfer rate (mucosa to portal vein blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="X-_sWgRPRESJT7uTKQD4iw" isDefault="1" displayUnit="µmol/min">
+                        <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                      </Parameter>
+                      <Transport id="AYS0XxJAOE-1gZRy9mnWRA" name="MassTransferMucosaToPveBC" description="Mass transfer from Mucosa:Blood Cells To Portal Vein: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="Q4p2g3ZtDESOUO3NMZli_Q" sourceAmount="1QLHcUXHTEqOYm9JCRavcw" targetAmount="RCAqJaBNgE-vkuaKfPZpnw" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="M93wIAWH-UmUNOZextgtEQ" name="Lumen_sto_Lumen_duo" description="Neighborhood between Lumen/Stomach and Lumen/Duodenum" mode="Logical" containerType="Neighborhood" firstNeighbor="YK1AJzgljEe91cerAd5phA" secondNeighbor="FiXHspIznEeQWrX1VkMsyg">
+                <Tags>
+                  <Tag value="Neighborhood: Stomach / Duodenum" />
+                </Tags>
+                <Children>
+                  <Container id="3XwGJT2K9kexqylQLSkI0g" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="EHLH6gABuU-V-yLH2vNWLQ" name="Oral mass absorbed" description="Oral mass absorbed from Lumen into mucosa" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" formula="thCmJBlzUUWD4O2fDYq6HA" isDefault="1" displayUnit="µmol">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Transport id="dA31wEmoS0SHdPjjlSiADA" name="LumenDrugTransport_duo" description="Lumen drug transport from Stomach to Duodenum" mode="Logical" containerType="Transport" dimension="Amount per time" formula="zagwYXuYtEqPNm35I2K1Ew" sourceAmount="4PpwVZlVAkOcD3Z34R328w" targetAmount="QIs0jmUAIE6ikShycjAOCw" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="LdWy6m-iSkq89Jo2nOKBTQ" name="Lumen_duo_Lumen_uje" description="Neighborhood between Lumen/Duodenum and Lumen/Upper Jejunum" mode="Logical" containerType="Neighborhood" firstNeighbor="FiXHspIznEeQWrX1VkMsyg" secondNeighbor="Al-BX9A42kuv1-su9wdy3g">
+                <Tags>
+                  <Tag value="Neighborhood: Duodenum / UpperJejunum" />
+                </Tags>
+                <Children>
+                  <Container id="DwWW1NwWj0-wrjWxL2oQvQ" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="xfqQKesnbUSXTUSyGvEzFw" name="LumenDrugTransport_uje" description="Lumen drug transport from Duodenum to Upper Jejunum" mode="Logical" containerType="Transport" dimension="Amount per time" formula="CxzGBUUMf0unJ4nD6kr5rg" sourceAmount="QIs0jmUAIE6ikShycjAOCw" targetAmount="CSHZ6BJVOEyAMrV3APtuzA" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="0SJjldbc40C6eqzTAvpS4A" name="Lumen_uje_Lumen_lje" description="Neighborhood between Lumen/Upper Jejunum and Lumen/Lower Jejunum" mode="Logical" containerType="Neighborhood" firstNeighbor="Al-BX9A42kuv1-su9wdy3g" secondNeighbor="fitLwZdQGUqPqO1eHGEd4A">
+                <Tags>
+                  <Tag value="Neighborhood: UpperJejunum / LowerJejunum" />
+                </Tags>
+                <Children>
+                  <Container id="GolFTpwsPUmAsePBbboJaA" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="EkcIGJrNlUm9qIVswNsyvg" name="LumenDrugTransport_lje" description="Lumen drug transport from Upper Jejunum to Lower Jejunum" mode="Logical" containerType="Transport" dimension="Amount per time" formula="1Je3ckHVe0yBsEaHPwln8A" sourceAmount="CSHZ6BJVOEyAMrV3APtuzA" targetAmount="PAqF1HO7pkuY5X-5OikQTw" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="yIQL7HPI4EyYwINwbpmnTQ" name="Lumen_lje_Lumen_uil" description="Neighborhood between Lumen/Lower Jejunum and Lumen/Upper Ileum" mode="Logical" containerType="Neighborhood" firstNeighbor="fitLwZdQGUqPqO1eHGEd4A" secondNeighbor="KtAGIWDpxEqLmrfrjfTgOQ">
+                <Tags>
+                  <Tag value="Neighborhood: LowerJejunum / UpperIleum" />
+                </Tags>
+                <Children>
+                  <Container id="WMh2q9w3LE-ZCjUEiaKuEA" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="t2TsoN4p20qSKgGFAeobVQ" name="LumenDrugTransport_uil" description="Lumen drug transport from Lower Jejunum to Upper Ileum" mode="Logical" containerType="Transport" dimension="Amount per time" formula="EH1_CF3m_0-bpkryCP7Ckw" sourceAmount="PAqF1HO7pkuY5X-5OikQTw" targetAmount="umlbmscJb0GFu_HR4Gat4w" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="Ose8WLGTqE-gfT0gVPqDJg" name="Lumen_uil_Lumen_lil" description="Neighborhood between Lumen/Upper Ileum and Lumen/Lower Ileum" mode="Logical" containerType="Neighborhood" firstNeighbor="KtAGIWDpxEqLmrfrjfTgOQ" secondNeighbor="gjNISeFIg0K-eV7qBurIeg">
+                <Tags>
+                  <Tag value="Neighborhood: UpperIleum / LowerIleum" />
+                </Tags>
+                <Children>
+                  <Container id="S5UgsQ8BUEyfTa9CT-i8Eg" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="84YuZwc9pUG8PBnkxS6ZDA" name="LumenDrugTransport_lil" description="Lumen drug transport from Upper Ileum to Lower Ileum" mode="Logical" containerType="Transport" dimension="Amount per time" formula="Xv4CPAhne0qeiwcNckSyJQ" sourceAmount="umlbmscJb0GFu_HR4Gat4w" targetAmount="KB6CzQCDLEOmMSsCvtbbxA" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="dbdX7GBy8kumBkxTgwN9Ew" name="Lumen_lil_Lumen_cae" description="Neighborhood between Lumen/Lower Ileum and Lumen/Cecum" mode="Logical" containerType="Neighborhood" firstNeighbor="gjNISeFIg0K-eV7qBurIeg" secondNeighbor="uYzhyHESRE2AJZ8aM48hjw">
+                <Tags>
+                  <Tag value="Neighborhood: LowerIleum / Caecum" />
+                </Tags>
+                <Children>
+                  <Container id="k0aJ-BIZcEyqrDEy9DjY_g" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="Td-NRzNTn0GU7N_MRhPRFg" name="LumenDrugTransport_cae" description="Lumen drug transport from Lower Ileum to Cecum" mode="Logical" containerType="Transport" dimension="Amount per time" formula="lWDW2cKlKUK_Br_izF1mvw" sourceAmount="KB6CzQCDLEOmMSsCvtbbxA" targetAmount="bl-WKAeEGkqp-gMj0y8wBQ" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="mAYMRn8ZukifMXhot2QILQ" name="Lumen_cae_Lumen_colasc" description="Neighborhood between Lumen/Cecum and Lumen/Colon Ascendens" mode="Logical" containerType="Neighborhood" firstNeighbor="uYzhyHESRE2AJZ8aM48hjw" secondNeighbor="tkfxCJO3sk6qgcu2TdYoFQ">
+                <Tags>
+                  <Tag value="Neighborhood: Caecum / ColonAscendens" />
+                </Tags>
+                <Children>
+                  <Container id="W6-bzs6Tz02fvymWkJpyjg" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="VlczfEp6Y0W_mrqaa3BB_w" name="LumenDrugTransport_colasc" description="Lumen drug transport from Cecum to Colon Ascendens" mode="Logical" containerType="Transport" dimension="Amount per time" formula="HLoj9n0y2kqjx9FMcu5rQg" sourceAmount="bl-WKAeEGkqp-gMj0y8wBQ" targetAmount="JpU_43QuWEeLn_RwxMDZeA" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="eJcmUcBBQkG4JlNKB5CO_A" name="Lumen_colasc_Lumen_coltrans" description="Neighborhood between Lumen/Colon Ascendens and Lumen/Colon Transversum" mode="Logical" containerType="Neighborhood" firstNeighbor="tkfxCJO3sk6qgcu2TdYoFQ" secondNeighbor="lYdNatoo8k6R4a61MnSWxw">
+                <Tags>
+                  <Tag value="Neighborhood: ColonAscendens / ColonTransversum" />
+                </Tags>
+                <Children>
+                  <Container id="AtiwZdkdKU-M0H50pf9gGA" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="nZvuETnGKEu0AikrXE-Uow" name="LumenDrugTransport_coltrans" description="Lumen drug transport from Colon Ascendens to Colon Transversum" mode="Logical" containerType="Transport" dimension="Amount per time" formula="B3ZrPQRwC0Ct_czimj_kXg" sourceAmount="JpU_43QuWEeLn_RwxMDZeA" targetAmount="Q5OEj64gBkqtBIJ7GLeeGw" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="kCg_Dtr98ESxCuDrTmGIjg" name="Lumen_coltrans_Lumen_coldesc" description="Neighborhood between Lumen/Colon Transversum and Lumen/Colon Descendens" mode="Logical" containerType="Neighborhood" firstNeighbor="lYdNatoo8k6R4a61MnSWxw" secondNeighbor="V5WMpuj5yEWwcXqu6PUWjQ">
+                <Tags>
+                  <Tag value="Neighborhood: ColonTransversum / ColonDescendens" />
+                </Tags>
+                <Children>
+                  <Container id="6ZltBECHSUmWx2mfqKyC3A" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="njWyCH38wUuDbcRmn1rBvQ" name="LumenDrugTransport_coldesc" description="Lumen drug transport from Colon Transversum to Colon Descendens" mode="Logical" containerType="Transport" dimension="Amount per time" formula="ixBUsN5JsE2D0Tb7OAeNbg" sourceAmount="Q5OEj64gBkqtBIJ7GLeeGw" targetAmount="C6DyIFKpeEmKqHkrCOLznw" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="0G20BPC21USOa9RvuVGssw" name="Lumen_coldesc_Lumen_colsigm" description="Neighborhood between Lumen/Colon Descendens and Lumen/Colon Sigmoid" mode="Logical" containerType="Neighborhood" firstNeighbor="V5WMpuj5yEWwcXqu6PUWjQ" secondNeighbor="QrFcARY080K42hhS9X8Hvg">
+                <Tags>
+                  <Tag value="Neighborhood: ColonDescendens / ColonSigmoid" />
+                </Tags>
+                <Children>
+                  <Container id="O5jWvHBvL0qCy7ZuSG80Mw" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="obb7RVSiukG3H9rNsnwEIQ" name="LumenDrugTransport_colsigm" description="Lumen drug transport from Colon Descendens to Colon Sigmoid" mode="Logical" containerType="Transport" dimension="Amount per time" formula="GMPu6aPIWUKpbKJY4uh_IA" sourceAmount="C6DyIFKpeEmKqHkrCOLznw" targetAmount="Fza7BQhGyUqFqjma1_gXAQ" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="CwqaIEAn00acqrgIy2dB6Q" name="Lumen_colsigm_Lumen_rect" description="Neighborhood between Lumen/Colon Sigmoid and Lumen/Rectum" mode="Logical" containerType="Neighborhood" firstNeighbor="QrFcARY080K42hhS9X8Hvg" secondNeighbor="jUxouOhem0ep-Qu6MPS_aw">
+                <Tags>
+                  <Tag value="Neighborhood: ColonSigmoid / Rectum" />
+                </Tags>
+                <Children>
+                  <Container id="n2Wb_cbQPUGQPb4f_vV9pA" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="pLLEHHZ6dES8agl2gJ2UQw" name="LumenDrugTransport_rect" description="Lumen drug transport from Colon Sigmoid to Rectum" mode="Logical" containerType="Transport" dimension="Amount per time" formula="8QQ_nI93pE2KK_vgIpIFFw" sourceAmount="Fza7BQhGyUqFqjma1_gXAQ" targetAmount="jMO_rCAwBkWG0LU4CcM-ew" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="-8no0rmktUmlpM2EoGiSQA" name="Lumen_rect_Lumen_fec" description="Neighborhood between Lumen/Rectum and Lumen/Feces" mode="Logical" containerType="Neighborhood" firstNeighbor="jUxouOhem0ep-Qu6MPS_aw" secondNeighbor="3aTpkWxuxEGmx-15pjzBvw">
+                <Tags>
+                  <Tag value="Neighborhood: Rectum / Feces" />
+                </Tags>
+                <Children>
+                  <Container id="slnByY1WTEu-Ou7EndvpsA" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="Ij0I2ceGGUOqdeeAeiIiog" name="LumenDrugTransport_fec" description="Lumen drug transport from Rectum to Feces" mode="Logical" containerType="Transport" dimension="Amount per time" formula="TeFLGIJZD0iSbL8pGOiqOw" sourceAmount="jMO_rCAwBkWG0LU4CcM-ew" targetAmount="tXiqJYw4vU2NkwVEuobrOQ" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="77hPlNvJs0uQhqAy0Gvong" name="Stomach_bc_PortalVein_bc" description="Neighborhood between Stomach/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="S67OZB6elkOyyWZ-Fje_IQ" secondNeighbor="-iUsllv1MkOvPkSoihwHiA">
+                <Tags>
+                  <Tag value="Neighborhood: BloodCells / BloodCells" />
+                </Tags>
+                <Children>
+                  <Container id="M5m58RjFx0CVRYNLTBFLeg" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="FzWIc4qNR0OJCITlTUIFNQ" name="MassTransferOrgRBC2BloodPool_Pve" description="Mass transfer from organ: Blood Cells to Portal Vein: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="rgdim7bfE0SPm-mCvH4OHQ" sourceAmount="DYkNHTJFi06Z_FYe4PQWkw" targetAmount="RCAqJaBNgE-vkuaKfPZpnw" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="0IrRSDf7kkq0EIkbscSHGA" name="Stomach_int_Stomach_cell" description="Neighborhood between Stomach/Interstitial and Stomach/Intracellular" mode="Logical" containerType="Neighborhood" firstNeighbor="2kef6uFgQE-6qFQHEbwo0g" secondNeighbor="nTOZsHGCcEqx9ii4QzE3Ew">
+                <Tags>
+                  <Tag value="Neighborhood: Interstitial / Intracellular" />
+                </Tags>
+                <Children>
+                  <Container id="1BfnGA0xek-Lfw6jtk_RLA" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="AxM7c_QP0kSd_MSQA_wLYA" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="iF9O5xA_e0SIVFmFG1ht8A" isDefault="1" displayUnit="cm/min">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="78" />
+                      </Parameter>
+                      <Parameter id="WLQSVutpSk-oHKsRAD-LYg" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="IKrcjT7b50S-hZpXm7B5cQ" isDefault="1" displayUnit="cm/min">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="76" />
+                      </Parameter>
+                      <Parameter id="oCzR7_f7tEqeEUP6ygPWQg" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="M2WXUlVpY0W18PhhdNB88Q" isDefault="1" displayUnit="l/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="LCeDyIAHlUOT5sOUNxD_Wg" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="70Te4TWLFEi68KKWZ6BTqA" isDefault="1" displayUnit="l/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="_cihjlyQ-0iAOjqQsfdrCw" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="A3PaZhBAJUmr17GM7HkynA" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="W_7esKlkakyTqOYG3aqJyA" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="JFtV3eMCF0qAMQ4c_5jB6Q" isDefault="1">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="69" />
+                      </Parameter>
+                      <Parameter id="8l3sdHwktUyGHrogspj5nA" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cf5OHy-pE0-BjjqyfS_nTg" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+                      </Parameter>
+                      <Parameter id="NZd3CXTeEkeor_tyfYRisA" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="uoffcXpID0uk5jk2l17XGA" isDefault="1">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Transport id="eItvctIbd0-lxDv5CSqNiw" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Transport" dimension="Amount per time" formula="Yf3FDmKIlk2UT-sMPQeO-A" sourceAmount="IqT8dYMJ-0yYkcV6-6qNiA" targetAmount="Hn46e_QSAESEpFXkEnLCTA" />
+                    </Children>
+                  </Container>
+                  <Parameter id="hNWSK4BZTUK4-CkKBei90g" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="ZjD1hTKeIES10CzhtqenlQ" isDefault="1" displayUnit="cm²">
+                    <Tags>
+                      <Tag value="Neighborhood: Interstitial / Intracellular" />
+                    </Tags>
+                    <Info min="0" flag="122" seq="17" ref="0" bb="32" group="105" />
+                  </Parameter>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="XSQ68XuVpE6cQG90zEk4vA" name="Stomach_pls_PortalVein_pls" description="Neighborhood between Stomach/Plasma and PortalVein/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="XcgWz7kj0EeW4Lgi_bRWBg" secondNeighbor="s_QiQGLN10Omt7YLmTFwjg">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / Plasma" />
+                </Tags>
+                <Children>
+                  <Container id="XrSXviaGn06_b-bmLRHz4Q" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="3fVWIpM_7EauaFZZMTMYLA" name="MassTransferOrgPl2BloodPool_pve" description="Mass transfer from organ: Plasma to Portal Vein: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="Blx3I6gCr0mOT31NaeV0Kg" sourceAmount="OtZkUmx1dESechCvzFNp-w" targetAmount="JvJXBdwv-UOGE6DoopBJuA" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="t0-gChAS_UmDEL3o6kCvoQ" name="Stomach_pls_Stomach_bc" description="Neighborhood between Stomach/Plasma and Stomach/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="XcgWz7kj0EeW4Lgi_bRWBg" secondNeighbor="S67OZB6elkOyyWZ-Fje_IQ">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / BloodCells" />
+                </Tags>
+                <Children>
+                  <Container id="4ApryA_JG02V_lvppfY64Q" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="KMT_ARi9-EC7UIwRUjcvgQ" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="Zbtb0FrFnkKP9iFHrn6nfA" sourceAmount="OtZkUmx1dESechCvzFNp-w" targetAmount="DYkNHTJFi06Z_FYe4PQWkw" />
+                    </Children>
+                  </Container>
+                  <Parameter id="KUqjJWFSf0mJpDFVw9rFkQ" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="fQWYYjitoUSu8LCUPjFStQ" isDefault="1" displayUnit="cm²">
+                    <Tags>
+                      <Tag value="Neighborhood: Plasma / BloodCells" />
+                    </Tags>
+                    <Info min="0" flag="122" seq="20" ref="0" bb="32" group="104" />
+                  </Parameter>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="2nyYP55EJk6NP-bJ9cMUaA" name="Stomach_pls_Stomach_int" description="Neighborhood between Stomach/Plasma and Stomach/Interstitial" mode="Logical" containerType="Neighborhood" firstNeighbor="XcgWz7kj0EeW4Lgi_bRWBg" secondNeighbor="2kef6uFgQE-6qFQHEbwo0g">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / Interstitial" />
+                </Tags>
+                <Children>
+                  <Container id="gsFT2SIAREKT3rJz8Qw-3g" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="wiLQeYbqeUmz9AHM44yf5A" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
+                        <ValueOrigin id="49" source="Other" method="Assumption" description="Assumption: very fast exchange" />
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="77" />
+                      </Parameter>
+                      <Parameter id="p4fE7Cn-0kGAep93vWllMw" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="WO-8Vog5vUuNvOpjrIOoOg" isDefault="1">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="70" />
+                      </Parameter>
+                      <Transport id="096G1A1MaUGIyPY93KE2Vw" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Transport" dimension="Amount per time" formula="PxQJDDgDDUu6oZyT4SgF4A" sourceAmount="OtZkUmx1dESechCvzFNp-w" targetAmount="IqT8dYMJ-0yYkcV6-6qNiA" />
+                    </Children>
+                  </Container>
+                  <Parameter id="uT_VkKMz7kuPO_TSBJhNuw" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="uM2afR7yPEGd8Nc0isIbTw" isDefault="1" displayUnit="cm²">
+                    <Tags>
+                      <Tag value="Neighborhood: Plasma / Interstitial" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="17" ref="0" bb="32" group="106" />
+                  </Parameter>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="AnANdc8KvkGttzCWSt7mjw" name="Lumen_uil_UpperIleum_pls" description="Neighborhood between Lumen/Upper Ileum and Mucosa/Upper Ileum/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="KtAGIWDpxEqLmrfrjfTgOQ" secondNeighbor="Y_s9pV1ZD0Ww0f15vGUCCQ">
+                <Tags>
+                  <Tag value="Neighborhood: UpperIleum / Plasma" />
+                </Tags>
+                <Children>
+                  <Container id="d6RjVGpHqEe39fXu14FEpw" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="IYha6VpnakCH-R4udufqWg" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="untJk_X5Q0-ipDAnGGQkYA" isDefault="1" displayUnit="µmol/min">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                      </Parameter>
+                      <Parameter id="GblwxeP5fUCrcCNUR3S32A" name="Sum of active process rates" description="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="IQum4-VT4EuSqwE5wvfsUA" isDefault="1" displayUnit="µmol/min">
+                        <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="ovXDbTR7nU-knE12VSKbzA" name="Sum of passive process rates" description="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="a4YFQAfjUEOvpC-PIvpvlw" isDefault="1" displayUnit="µmol/min">
+                        <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Transport id="22Oq8A3VHkmGNEqAVsvhNQ" name="DrugAbsorption_para" description="Drug absorption paracellular" mode="Logical" containerType="Transport" dimension="Amount per time" formula="Il9HnR8kOU-LAWU5HOubvQ" sourceAmount="umlbmscJb0GFu_HR4Gat4w" targetAmount="5v1KSGAk70O10rniubnfVw">
+                        <Children>
+                          <Parameter id="k_EgQVqIhk2ySVO-QNX5zA" name="ProcessRate" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="h2qqrPn_7UaZk5joZ7vVbQ" isDefault="1" displayUnit="µmol/min">
+                            <Tags>
+                              <Tag value="DrugAbsorption_para" />
+                              <Tag value="ProcessRate" />
+                              <Tag value="Aciclovir" />
+                              <Tag value="Lumen_uil_UpperIleum_pls" />
+                              <Tag value="Passive" />
+                            </Tags>
+                            <Info flag="6" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                        </Children>
+                      </Transport>
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="xK2KQ_IguE6o_ChJ6osEww" name="Lumen_uil_UpperIleum_cell" description="Neighborhood between Lumen/Upper Ileum and Mucosa/Upper Ileum/Intracellular" mode="Logical" containerType="Neighborhood" firstNeighbor="KtAGIWDpxEqLmrfrjfTgOQ" secondNeighbor="Ff3WHy-9B0m4L3fVbldxJw">
+                <Tags>
+                  <Tag value="Neighborhood: UpperIleum / Intracellular" />
+                </Tags>
+                <Children>
+                  <Container id="LiUXLWwDf0aCb8KIgG9nvw" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="oKihLsEKkEqXcimalOO1hg" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="QVmEk5WKP0GsV75hthubnw" isDefault="1" displayUnit="µmol/min">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                      </Parameter>
+                      <Parameter id="nZy9UeEF0UmWRz57zggASQ" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="3y6-m8wgOEKD3GtEjz0zzg" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="fbjN_t7MkE2CAQ5oYG3mfQ" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="lJ91Y9prMU-IAOmp8VeUZA" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="g5tr6UxUUUej3TVVjvJZqg" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="M7nEr1CKgEmsTr1m4G-MmQ" isDefault="1">
+                        <Info min="0" flag="36" seq="1" ref="0" bb="2" group="67" />
+                      </Parameter>
+                      <Parameter id="xbVdhxZTe0aLJGSTqnVlGA" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="xfph776CnEy-2qFur5BNHg" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+                      </Parameter>
+                      <Parameter id="kB6_9mUEBEW5MvdpYXvlTQ" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="k_k1j6AJTUuoTLsJoB0yPg" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="6ZWmv3j6r0mkLA_r5OFMQA" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="8PELnSc-50Wg5ugoFSli4A" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="-OCX10BE3Emi3FYIJLQNEQ" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="CogAfmQGV0mzrLv3RDQOLw" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="7XvauhVLXkSAPH3ygIkAgA" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="lfuixO3kjEW_DgVwm-NEkA" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="0DUxWlaoyU2-3ypJ3ddvbw" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="wpZOWtsCVEivIawZ0cJTQQ" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="CRUSLUY0sUyXsXNfR_VEZA" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="zDjvv8qD_0q6sFClKz_6Dw" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="dg0tUrgA50q9g6BCbTAsXw" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IIYsrx_Fhkm3HVhCSgi4JA" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="aobVJ9rsGkuGuHulD-38cQ" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="unqtYV5AeEOgOCuJHP2VSA" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="WYWUfIrG_0auYU4raIMp6g" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="bpZDuWciwU2LDzUNVjrx2A" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="hrLiaw7U4U-pMw_SLU64XA" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="WlVW33RvI0izDWhDdH2ACw" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="MNr7WiVK7kCbhL-Styh8PQ" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="lZaz3UUV6EeQOunL9WZ4_g" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="p4nxVR1S9EWcXCIudh8Iyg" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="OfHsbS1bA02-vaMDrU8PQw" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="zgnOq5N3gk6lgpk-kAP3yA" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="UfN6hHfK8U2_4lCZn8PX2w" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="Kc7HpeQF6k6_1PLHSDYbzw" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="dRUsAzJlPk6nHsGMdChQUw" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="5lTiO0gIFUWgaclNh2_svA" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="5JG_BBjIek6qnerxqqbp5A" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="bXuv2504r0qKe5Xt_8Mwbg" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="9Avqn_lfmkOYWTl8-_rMmg" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="WqVHqhowFU2RsMc7FuuyBQ" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ucHi0vXPN0WPpok-4cCWCQ" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="fyRmw_vXLkW1S6YVrXq0IQ" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Q7JAceEGmkCCiLcIdSgVFg" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="3kk1Ijvn3Ua9UZrTpOORLQ" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cg3-HM5rEkyKAe6nt4Tgnw" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="yUlGMw00aU2f8jYk_fJXyQ" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="rI_XOwPh-kSUkyS48tdLCw" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="9pg69VwGIE6CgJcuAtasYA" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="2MsqcDgQ9kWp8tSdr6OMJQ" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="z5QkeMKtLkG5QMExgV2fgQ" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="fRQlUllt4kGqcKWlmlGP7g" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="TfvOldcBhE6nfDrxDTsmUQ" name="Sum of active process rates" description="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="KlE2pl8RrUS6DTUxFVpOcw" isDefault="1" displayUnit="µmol/min">
+                        <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="tsQTIF1h3kqcY3yqbHxICg" name="Sum of passive process rates" description="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="RpKyOI9sxEuXbJo9SaUqiA" isDefault="1" displayUnit="µmol/min">
+                        <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Transport id="9DDpkrItTE-tvbcb1irOww" name="DrugAbsorption_trans" description="Drug absorption transcellular" mode="Logical" containerType="Transport" dimension="Amount per time" formula="_EADQecFCkm2H9vVkx8gzg" sourceAmount="umlbmscJb0GFu_HR4Gat4w" targetAmount="464kpYtSoEmHbsxIEfBICQ">
+                        <Children>
+                          <Parameter id="qGapMBwzmkC5khq9UOs4_w" name="ProcessRate" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="-VzBm9wFOkuuu9iS1KPbgg" isDefault="1" displayUnit="µmol/min">
+                            <Tags>
+                              <Tag value="DrugAbsorption_trans" />
+                              <Tag value="ProcessRate" />
+                              <Tag value="Aciclovir" />
+                              <Tag value="Lumen_uil_UpperIleum_cell" />
+                              <Tag value="Passive" />
+                            </Tags>
+                            <Info flag="6" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                        </Children>
+                      </Transport>
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="3HFfBeg57ESSDQ_B2XDUiQ" name="UpperIleum_pls_PortalVein_pls" description="Neighborhood between Upper Ileum/Plasma and PortalVein/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="Y_s9pV1ZD0Ww0f15vGUCCQ" secondNeighbor="s_QiQGLN10Omt7YLmTFwjg">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / Plasma" />
+                </Tags>
+                <Children>
+                  <Container id="vdEKbiRR5EG2DEHLihcDjQ" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="MhoxdvBBpUeNDmTXnnNOcw" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="TOg1VORWfE-v93QeXh2R0g" isDefault="1" displayUnit="µmol/min">
+                        <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                      </Parameter>
+                      <Transport id="WqGcLvspFUe2NdHmAvtfhQ" name="MassTransferMucosaToPvePlasma" description="Mass transfer from Mucosa:Plasma To Portal Vein: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="x7Z4h3_AbEiOOP7aacWZNg" sourceAmount="5v1KSGAk70O10rniubnfVw" targetAmount="JvJXBdwv-UOGE6DoopBJuA" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="iXuceZOuvUaFpzm2qHAa4g" name="UpperIleum_bc_PortalVein_bc" description="Neighborhood between Upper Ileum/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="LlnYb8D-S0u4Z42FsmcSiA" secondNeighbor="-iUsllv1MkOvPkSoihwHiA">
+                <Tags>
+                  <Tag value="Neighborhood: BloodCells / BloodCells" />
+                </Tags>
+                <Children>
+                  <Container id="0AilIhPvQESj9ieZUpnbAg" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="qI9DRAe6iUm3GFZhf560CA" name="Mass transfer rate (mucosa to portal vein blood cells)" description="Mass transfer rate (mucosa to portal vein blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="3w-ozlHVrkyei8RWLX3f1g" isDefault="1" displayUnit="µmol/min">
+                        <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                      </Parameter>
+                      <Transport id="PUsCQ3xznEOqSNzJvNpA2A" name="MassTransferMucosaToPveBC" description="Mass transfer from Mucosa:Blood Cells To Portal Vein: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="MAm6kWB13kukTKFvrEI3gg" sourceAmount="do9IUbs9QUm3akwTT0LqpQ" targetAmount="RCAqJaBNgE-vkuaKfPZpnw" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="REH25LHMqES1yDQT1Cpj2g" name="SmallIntestine_bc_PortalVein_bc" description="Neighborhood between Small Intestine/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="Tg8zUU7tQUiyXi7TzpD9tA" secondNeighbor="-iUsllv1MkOvPkSoihwHiA">
+                <Tags>
+                  <Tag value="Neighborhood: BloodCells / BloodCells" />
+                </Tags>
+                <Children>
+                  <Container id="0naBoZART0-zmrHZsoxvgw" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="ptfnUweAe0iNvDp4b4h7KA" name="MassTransferSinRBC2BloodPool_Pve" description="Mass transfer from Small Intestine:Blood Cells to Portal Vein: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="65yFPxZkgkC0hugNycCPyg" sourceAmount="40NocQSNtUSnzThV6rVJSA" targetAmount="RCAqJaBNgE-vkuaKfPZpnw" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="jEUN_uMSuU2LyG5lF0Okbg" name="SmallIntestine_int_SmallIntestine_cell" description="Neighborhood between Small Intestine/Interstitial and Small Intestine/Intracellular" mode="Logical" containerType="Neighborhood" firstNeighbor="mtBqHFMwREWbA3rNCZF8cw" secondNeighbor="295zoSg3ykyS0pnDU5gf5w">
+                <Tags>
+                  <Tag value="Neighborhood: Interstitial / Intracellular" />
+                  <Tag value="Small intestine  neighborhood" />
+                </Tags>
+                <Children>
+                  <Container id="ZLivNrJj70qK6aOE6lTfSg" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="boAkXmD5O0uOXMTXSw-Row" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="iF9O5xA_e0SIVFmFG1ht8A" isDefault="1" displayUnit="cm/min">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="78" />
+                      </Parameter>
+                      <Parameter id="z0gM6SBAakG-vszp1xmllA" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="IKrcjT7b50S-hZpXm7B5cQ" isDefault="1" displayUnit="cm/min">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="76" />
+                      </Parameter>
+                      <Parameter id="Y_Oj3MEMD0aXcGuRxYjfEw" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="M2WXUlVpY0W18PhhdNB88Q" isDefault="1" displayUnit="l/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="elwyXQTJ1E2M4t8GPjWlcA" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="70Te4TWLFEi68KKWZ6BTqA" isDefault="1" displayUnit="l/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="9CM8T2DSX0a6Bf9cgq3pVA" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="jFzqERGib0-7NExpv_VxYw" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="h2iIw72BQUa8MH8Ipw8I4g" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="4-ztMy_bO0aiyUfPf0r4_w" isDefault="1">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="69" />
+                      </Parameter>
+                      <Parameter id="JqO7vz_8-ke_cX4Jl9gRZw" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cf5OHy-pE0-BjjqyfS_nTg" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+                      </Parameter>
+                      <Parameter id="TvVtgMGsqkagR-mfYh2tDQ" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="4BlVBMvtg0Gz7B9zQVORSw" isDefault="1">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Transport id="XdCN00dsg0yZSrDTkuj7YA" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Transport" dimension="Amount per time" formula="ed1j4XnE5EmJh4J4RPFAoQ" sourceAmount="5sK0jN2nMkySn95JXysk_g" targetAmount="XA5bEMsBHEOyIw_Q6kJo3A" />
+                    </Children>
+                  </Container>
+                  <Parameter id="ykAO3pzQNUmpQrxxYYR0dg" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="HMqm-oQ__0CHl3x_X7lmbg" isDefault="1" displayUnit="cm²">
+                    <Tags>
+                      <Tag value="Neighborhood: Interstitial / Intracellular" />
+                      <Tag value="Small intestine  neighborhood" />
+                    </Tags>
+                    <Info min="0" flag="122" seq="15" ref="0" bb="32" group="105" />
+                  </Parameter>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="S6G3ggaUl0uDZYgN3LgDXA" name="SmallIntestine_pls_PortalVein_pls" description="Neighborhood between Small Intestine/Plasma and PortalVein/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="Fy6Itf9MIUGQAeAvyt7KGg" secondNeighbor="s_QiQGLN10Omt7YLmTFwjg">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / Plasma" />
+                </Tags>
+                <Children>
+                  <Container id="yOphXwtFk0S6a0zEAEPGfg" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="YuFLvrnIgku7636ip3uGgg" name="MassTransferSinPlasma2BloodPool_Pve" description="Mass transfer from Small Intestine:Plasma to Portal Vein: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="xKIJdi9jjUOP94n7QtgWjA" sourceAmount="WaDZEuqgsEyV_ckNljlU_g" targetAmount="JvJXBdwv-UOGE6DoopBJuA" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="ewkbdsF1DEerrxMOVNt25A" name="SmallIntestine_pls_SmallIntestine_bc" description="Neighborhood between Small Intestine/Plasma and Small Intestine/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="Fy6Itf9MIUGQAeAvyt7KGg" secondNeighbor="Tg8zUU7tQUiyXi7TzpD9tA">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / BloodCells" />
+                  <Tag value="Small intestine  neighborhood" />
+                </Tags>
+                <Children>
+                  <Container id="Wv636apWL06_sPM1l7wpJQ" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="BzPOVt_1t0yRfDYva2FsTw" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="5Ci_zc7gdkCO9X2d_x_H4g" sourceAmount="WaDZEuqgsEyV_ckNljlU_g" targetAmount="40NocQSNtUSnzThV6rVJSA" />
+                    </Children>
+                  </Container>
+                  <Parameter id="lfUQsqwkzkKCSsZoHJgUcA" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="qOvN0VtU7km8hXEIK-gtrQ" isDefault="1" displayUnit="cm²">
+                    <Tags>
+                      <Tag value="Neighborhood: Plasma / BloodCells" />
+                      <Tag value="Small intestine  neighborhood" />
+                    </Tags>
+                    <Info min="0" flag="122" seq="18" ref="0" bb="32" group="104" />
+                  </Parameter>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="jTKal_S0jUK3rthDKz7YCA" name="SmallIntestine_pls_SmallIntestine_int" description="Neighborhood between Small Intestine/Plasma and Small Intestine/Interstitial" mode="Logical" containerType="Neighborhood" firstNeighbor="Fy6Itf9MIUGQAeAvyt7KGg" secondNeighbor="mtBqHFMwREWbA3rNCZF8cw">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / Interstitial" />
+                  <Tag value="Small intestine  neighborhood" />
+                </Tags>
+                <Children>
+                  <Container id="o5ue_c7ZDk2CYakMsy0FRQ" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="f49MToInK0iuNRHZK8BXmA" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
+                        <ValueOrigin id="49" source="Other" method="Assumption" description="Assumption: very fast exchange" />
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="77" />
+                      </Parameter>
+                      <Parameter id="9RXS12lOaEiNhQUUo_7f7A" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="WO-8Vog5vUuNvOpjrIOoOg" isDefault="1">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="70" />
+                      </Parameter>
+                      <Transport id="MUU3qnNb2U6VKLMtya93Bw" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Transport" dimension="Amount per time" formula="4UgM0CHntECV9_M7KtJEDQ" sourceAmount="WaDZEuqgsEyV_ckNljlU_g" targetAmount="5sK0jN2nMkySn95JXysk_g" />
+                    </Children>
+                  </Container>
+                  <Parameter id="gOL4ncRhTUODA4X9t_CE6A" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="RnxGrk4TsEurbtHtunu-Xw" isDefault="1" displayUnit="cm²">
+                    <Tags>
+                      <Tag value="Neighborhood: Plasma / Interstitial" />
+                      <Tag value="Small intestine  neighborhood" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="15" ref="0" bb="32" group="106" />
+                  </Parameter>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="kg2GQb2ZTUGOhnqlX5oXAA" name="SmallIntestine_pls_Duodenum_pls" description="Neighborhood between Small Intestine/Plasma_ and Duodenum/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="Fy6Itf9MIUGQAeAvyt7KGg" secondNeighbor="XAgCyFXUeEiKySGRkrx1lw">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / Plasma" />
+                </Tags>
+                <Children>
+                  <Container id="PKpiQtUlPU6ltKJpdcuvGA" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="cdSToaVZQkKF7FZejOI0ng" name="Mass transfer rate (intestine to mucosa plasma)" description="Mass transfer rate (intestine to mucosa plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="kaVGA1A2m0i5zU5bvfjDAw" isDefault="1" displayUnit="µmol/min">
+                        <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                      </Parameter>
+                      <Transport id="We7WmDTbrEuW3hy0b3UZcA" name="MassTransferSINToMucosaPlasma" description="Mass transfer from Small Intestine:Plasma to Mucosa: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="mw5m_Del_EW-RJuHSI6wBw" sourceAmount="WaDZEuqgsEyV_ckNljlU_g" targetAmount="6jMviBffOESTP5M0G7YuJg" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="j4xjHLlGMUe8CCffR8ikhA" name="SmallIntestine_bc_Duodenum_bc" description="Neighborhood between Small Intestine/Blood Cells_ and Duodenum/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="Tg8zUU7tQUiyXi7TzpD9tA" secondNeighbor="YoUcbCdrsUy6MzLzw16fQA">
+                <Tags>
+                  <Tag value="Neighborhood: BloodCells / BloodCells" />
+                </Tags>
+                <Children>
+                  <Container id="C_LahgKhKEueOYkf5R4MNA" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="60h0dc0SIU-hv-kg81yGfw" name="Mass transfer rate (intestine to mucosa blood cells)" description="Mass transfer rate (intestine to mucosa blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="K-2ldofE6EO88oROkpO4SA" isDefault="1" displayUnit="µmol/min">
+                        <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                      </Parameter>
+                      <Transport id="R0EPwAMqp066ktCUZrVV9Q" name="MassTransferSINToMucosaBC" description="Mass transfer from Small Intestine:Blood Cells to Mucosa: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="g-2tu9FSxEeGGhqIiM2CZw" sourceAmount="40NocQSNtUSnzThV6rVJSA" targetAmount="NSDFFYYE00y77UxrZNLCtQ" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="sanKOqJBEka9L2sMvsg_kw" name="SmallIntestine_pls_UpperJejunum_pls" description="Neighborhood between Small Intestine/Plasma_ and Upper Jejunum/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="Fy6Itf9MIUGQAeAvyt7KGg" secondNeighbor="AdnIgrbZwUCQM9gcoqPNFg">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / Plasma" />
+                </Tags>
+                <Children>
+                  <Container id="vGj3S7eyZUC8C6TFGXaj-Q" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="4qb7tzDR-0GRIEQwj3VW1A" name="Mass transfer rate (intestine to mucosa plasma)" description="Mass transfer rate (intestine to mucosa plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="plQtaOuUkE2YGl6EyJtvEQ" isDefault="1" displayUnit="µmol/min">
+                        <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                      </Parameter>
+                      <Transport id="ThlyzEGCYEC50F1vDSIqtQ" name="MassTransferSINToMucosaPlasma" description="Mass transfer from Small Intestine:Plasma to Mucosa: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="lnqRMywHx0OCViJxDedQfQ" sourceAmount="WaDZEuqgsEyV_ckNljlU_g" targetAmount="jXed7RBVDE-arIEOj4e22g" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="yBefNhH4uUusY7rS-Gk1zQ" name="SmallIntestine_bc_UpperJejunum_bc" description="Neighborhood between Small Intestine/Blood Cells_ and Upper Jejunum/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="Tg8zUU7tQUiyXi7TzpD9tA" secondNeighbor="Gu_kquVcG0O_zuSeiO8r4Q">
+                <Tags>
+                  <Tag value="Neighborhood: BloodCells / BloodCells" />
+                </Tags>
+                <Children>
+                  <Container id="E1fJwNtK1Em9OAs0MGn5jw" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="jtRMUQS0Ok2LludoNmXTKw" name="Mass transfer rate (intestine to mucosa blood cells)" description="Mass transfer rate (intestine to mucosa blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="BQT0GbyfI0GYLxATpr3EHQ" isDefault="1" displayUnit="µmol/min">
+                        <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                      </Parameter>
+                      <Transport id="5aYknhxMq0Gju1GflecReQ" name="MassTransferSINToMucosaBC" description="Mass transfer from Small Intestine:Blood Cells to Mucosa: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="uDAcwnCRkUC4WcuvaRgF3g" sourceAmount="40NocQSNtUSnzThV6rVJSA" targetAmount="_8TJYo65bE2WdF0w6RPdjQ" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="GlC5WEfkpEuY0O9Ds46uNg" name="SmallIntestine_pls_LowerJejunum_pls" description="Neighborhood between Small Intestine/Plasma_ and Lower Jejunum/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="Fy6Itf9MIUGQAeAvyt7KGg" secondNeighbor="UFlatkQIoEK5k-bXY6FG-Q">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / Plasma" />
+                </Tags>
+                <Children>
+                  <Container id="ODvUO3d16Uqu0Z3eH-FBdg" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="MMkEJ_6uJEeD7Z8pU9rtLA" name="Mass transfer rate (intestine to mucosa plasma)" description="Mass transfer rate (intestine to mucosa plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="GLDTd1HbwE-PuwKGZgJEwA" isDefault="1" displayUnit="µmol/min">
+                        <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                      </Parameter>
+                      <Transport id="JBPaGW7UKkmJ-IVxLFfTIg" name="MassTransferSINToMucosaPlasma" description="Mass transfer from Small Intestine:Plasma to Mucosa: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="Tum3qUSrG0SRBmLhGBHhuA" sourceAmount="WaDZEuqgsEyV_ckNljlU_g" targetAmount="MFQ1DjGCz0GYLNDQI5iUVg" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="3uq7yjMJLUqAidyYoiH8qQ" name="SmallIntestine_bc_LowerJejunum_bc" description="Neighborhood between Small Intestine/Blood Cells_ and Lower Jejunum/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="Tg8zUU7tQUiyXi7TzpD9tA" secondNeighbor="yDYh6-IkUEWuusihzT3Z-g">
+                <Tags>
+                  <Tag value="Neighborhood: BloodCells / BloodCells" />
+                </Tags>
+                <Children>
+                  <Container id="64oxwTkf2E-EDt2_2iGl-g" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="qiN043c0qUCCR8F-DpkaDw" name="Mass transfer rate (intestine to mucosa blood cells)" description="Mass transfer rate (intestine to mucosa blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="hm3ovruY50WifAjxF6qxcA" isDefault="1" displayUnit="µmol/min">
+                        <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                      </Parameter>
+                      <Transport id="NuOAnBfCRkemfDUMg1nSJw" name="MassTransferSINToMucosaBC" description="Mass transfer from Small Intestine:Blood Cells to Mucosa: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="3YQXxdeyYk2o6xs2QxJlww" sourceAmount="40NocQSNtUSnzThV6rVJSA" targetAmount="1QLHcUXHTEqOYm9JCRavcw" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="RTvIcEuXv0m-c6fXXSAxPg" name="SmallIntestine_pls_UpperIleum_pls" description="Neighborhood between Small Intestine/Plasma_ and Upper Ileum/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="Fy6Itf9MIUGQAeAvyt7KGg" secondNeighbor="Y_s9pV1ZD0Ww0f15vGUCCQ">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / Plasma" />
+                </Tags>
+                <Children>
+                  <Container id="dCY9lAncokad8T_gPLX1pw" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="fsrrNk5Bb0qcvrBbwHqIkw" name="Mass transfer rate (intestine to mucosa plasma)" description="Mass transfer rate (intestine to mucosa plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="JQYESJU6sE2mCjeEpv15SA" isDefault="1" displayUnit="µmol/min">
+                        <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                      </Parameter>
+                      <Transport id="r5KM7atyLk-aD0d44X2mVA" name="MassTransferSINToMucosaPlasma" description="Mass transfer from Small Intestine:Plasma to Mucosa: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="xz3GNbisYECQjCBc5Yxe0w" sourceAmount="WaDZEuqgsEyV_ckNljlU_g" targetAmount="5v1KSGAk70O10rniubnfVw" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="z3BcEqjHsEulA9YWHgEXyg" name="SmallIntestine_bc_UpperIleum_bc" description="Neighborhood between Small Intestine/Blood Cells_ and Upper Ileum/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="Tg8zUU7tQUiyXi7TzpD9tA" secondNeighbor="LlnYb8D-S0u4Z42FsmcSiA">
+                <Tags>
+                  <Tag value="Neighborhood: BloodCells / BloodCells" />
+                </Tags>
+                <Children>
+                  <Container id="iCbjdA03506evPTyekbrrQ" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="ueT0BUVWzEacqjesP983og" name="Mass transfer rate (intestine to mucosa blood cells)" description="Mass transfer rate (intestine to mucosa blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="xvZ0Ew1Eok-QasZhYXTXcg" isDefault="1" displayUnit="µmol/min">
+                        <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                      </Parameter>
+                      <Transport id="t_KRLGg-g0awBkCib3oaRQ" name="MassTransferSINToMucosaBC" description="Mass transfer from Small Intestine:Blood Cells to Mucosa: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="D8gV8kl5REerN1VhMachqw" sourceAmount="40NocQSNtUSnzThV6rVJSA" targetAmount="do9IUbs9QUm3akwTT0LqpQ" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="84OvSFV0_USYs0eGUPGnWA" name="Lumen_lil_LowerIleum_pls" description="Neighborhood between Lumen/Lower Ileum and Mucosa/Lower Ileum/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="gjNISeFIg0K-eV7qBurIeg" secondNeighbor="9tzwJZOJJ0-AQ1gsdsTzQA">
+                <Tags>
+                  <Tag value="Neighborhood: LowerIleum / Plasma" />
+                </Tags>
+                <Children>
+                  <Container id="n7FPkw6wC0qPUNaMbofeTg" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="LNj5IybGEkmBCRmZ3-N4ug" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="jE7iITlO4U-9xP3b_FzpfA" isDefault="1" displayUnit="µmol/min">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                      </Parameter>
+                      <Parameter id="yswfz7O5K0-bp1EwExL8Tw" name="Sum of active process rates" description="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="u-8Tbf9kP0W7rzHxWpbzkQ" isDefault="1" displayUnit="µmol/min">
+                        <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="WaxHvPaM2UKwZMJHOj_Hqg" name="Sum of passive process rates" description="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="vcARpCE_2UCH9ZhQXSjJpg" isDefault="1" displayUnit="µmol/min">
+                        <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Transport id="HsA3L6mLEEeOeOGQ478ltw" name="DrugAbsorption_para" description="Drug absorption paracellular" mode="Logical" containerType="Transport" dimension="Amount per time" formula="ZdtdIqxnFEmBXBrZg9S9lg" sourceAmount="KB6CzQCDLEOmMSsCvtbbxA" targetAmount="TC5L9nJpwkusWgAoYrAeGA">
+                        <Children>
+                          <Parameter id="pFDAxaxQwk-yyPsmr8__tA" name="ProcessRate" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="umA3SndA402CXp2jsNMTgw" isDefault="1" displayUnit="µmol/min">
+                            <Tags>
+                              <Tag value="DrugAbsorption_para" />
+                              <Tag value="ProcessRate" />
+                              <Tag value="Aciclovir" />
+                              <Tag value="Lumen_lil_LowerIleum_pls" />
+                              <Tag value="Passive" />
+                            </Tags>
+                            <Info flag="6" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                        </Children>
+                      </Transport>
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="HyrP2sLaMU2YwKraOCtbtA" name="Lumen_lil_LowerIleum_cell" description="Neighborhood between Lumen/Lower Ileum and Mucosa/Lower Ileum/Intracellular" mode="Logical" containerType="Neighborhood" firstNeighbor="gjNISeFIg0K-eV7qBurIeg" secondNeighbor="NJHSNYdpF0yRamDyRpn9Zw">
+                <Tags>
+                  <Tag value="Neighborhood: LowerIleum / Intracellular" />
+                </Tags>
+                <Children>
+                  <Container id="xzB6vxzQIUecKcUhECxXqw" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="zNBYNmUcwEyCsisvKuP92w" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="W2TqONNIkU-_EYym2i6V7g" isDefault="1" displayUnit="µmol/min">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                      </Parameter>
+                      <Parameter id="sEqkiOxBckKHbQ2T5xnF9g" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="3y6-m8wgOEKD3GtEjz0zzg" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="FnENem_7CEa0sJ2R2sqDkg" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="lJ91Y9prMU-IAOmp8VeUZA" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="WKDH4yH3dU2vRdb_qmxTaw" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="v3vzaETevUqImYA6Jcp1jg" isDefault="1">
+                        <Info min="0" flag="36" seq="1" ref="0" bb="2" group="67" />
+                      </Parameter>
+                      <Parameter id="XwqmhL9aMEugJ5NDxnz6WA" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="3wy7uYYb4kezLP5_Je8CbQ" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+                      </Parameter>
+                      <Parameter id="5pE6aJmvxUKYRgrS8_iEmA" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ChdFJ8HCZEiNnjbIiPM3-A" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="EXJRfHf2PkiVJqfUyTPaOQ" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="4eeff3h5qUWC9Ux2p9cdvw" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="u8TCLZsHG0i3SVzFTcQS6g" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="1VOv92zkkEmUlAsYn_7F7A" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="ys1GSdFmQUGlfqwnC6LFvw" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="lfuixO3kjEW_DgVwm-NEkA" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="07WwEOVsKkKHukyT9dT24A" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="wpZOWtsCVEivIawZ0cJTQQ" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="yu2MTT_5aEidLDEUKM_YKA" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="zDjvv8qD_0q6sFClKz_6Dw" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="BPEZT8oc6UmcRi5SJ9zIIA" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IIYsrx_Fhkm3HVhCSgi4JA" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="xciN51LDQkCeaMdpJASkAg" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="unqtYV5AeEOgOCuJHP2VSA" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="FHCE-hC-9USdUkgEJ3eNjw" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="bpZDuWciwU2LDzUNVjrx2A" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="ooJLAcWDoEuRFxIdEcMycw" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="WlVW33RvI0izDWhDdH2ACw" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="fddLwFA_iEqU34akbTR94A" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="lZaz3UUV6EeQOunL9WZ4_g" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="7KNoVB6xV0al8jK6wGvSug" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="8LdLJEp5tUK_24Fr0vBiaQ" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="mIgeQ-0wV0yeVqnfNYYNYw" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="eFBheauEq065ggK-OWIGZw" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="GnKmCC62RU2IYcMPbxTcvw" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="dmP-Ok9i2UOU7kSIb4NPYQ" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="gpYQGwh22EG2dmP8OmV4xg" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="5JG_BBjIek6qnerxqqbp5A" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="ATbDpSc3YEO-5N0jTZo9VQ" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="9Avqn_lfmkOYWTl8-_rMmg" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="ex65mdyZw02l6hvsYOn_Ng" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ucHi0vXPN0WPpok-4cCWCQ" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="KfapX-x8d0iixepcN26A6w" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Q7JAceEGmkCCiLcIdSgVFg" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="wngtd5MCHE644k7RWVYTfA" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cg3-HM5rEkyKAe6nt4Tgnw" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="KaCEyWct8k23NCcV3IpJqw" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="rI_XOwPh-kSUkyS48tdLCw" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="DQAT_YJXEEqdR6Dd_fjDeg" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="2MsqcDgQ9kWp8tSdr6OMJQ" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="9T8X8_3lFEyCBFk7vwMszQ" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="fRQlUllt4kGqcKWlmlGP7g" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="9d0ruVM8sEmjDVwklZH2jw" name="Sum of active process rates" description="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="ysW5vHpd-kK2F004tSGVzg" isDefault="1" displayUnit="µmol/min">
+                        <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="EwKlDkbs3k6-Q16O6FqxeA" name="Sum of passive process rates" description="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="ZQXHPum7_U6ezmvILqUbFA" isDefault="1" displayUnit="µmol/min">
+                        <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Transport id="aA4v-avmSUuxhdXbMrJMIA" name="DrugAbsorption_trans" description="Drug absorption transcellular" mode="Logical" containerType="Transport" dimension="Amount per time" formula="lQTGE9cIckSXtO8-AgRnPA" sourceAmount="KB6CzQCDLEOmMSsCvtbbxA" targetAmount="K-XpbxOHZEWVtNyPrJeVHA">
+                        <Children>
+                          <Parameter id="UF6F-RHVUUKqMzlYAXNonQ" name="ProcessRate" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="1GGtwpJ2Z0qxiLKcLgadzw" isDefault="1" displayUnit="µmol/min">
+                            <Tags>
+                              <Tag value="DrugAbsorption_trans" />
+                              <Tag value="ProcessRate" />
+                              <Tag value="Aciclovir" />
+                              <Tag value="Lumen_lil_LowerIleum_cell" />
+                              <Tag value="Passive" />
+                            </Tags>
+                            <Info flag="6" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                        </Children>
+                      </Transport>
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="AV07e9DshEaCGh81-OjIrw" name="SmallIntestine_pls_LowerIleum_pls" description="Neighborhood between Small Intestine/Plasma_ and Lower Ileum/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="Fy6Itf9MIUGQAeAvyt7KGg" secondNeighbor="9tzwJZOJJ0-AQ1gsdsTzQA">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / Plasma" />
+                </Tags>
+                <Children>
+                  <Container id="j5wjNCaWJUK5MvHs75kJIQ" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="am1lBa3AnUyEzdFv4xy-sg" name="Mass transfer rate (intestine to mucosa plasma)" description="Mass transfer rate (intestine to mucosa plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="wPX9PXXhH0a5-gCDjwq0JQ" isDefault="1" displayUnit="µmol/min">
+                        <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                      </Parameter>
+                      <Transport id="VJjn-uda4UOYXBEkLLzkMw" name="MassTransferSINToMucosaPlasma" description="Mass transfer from Small Intestine:Plasma to Mucosa: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="kbIXD29ykEmy1KDCfAQcfw" sourceAmount="WaDZEuqgsEyV_ckNljlU_g" targetAmount="TC5L9nJpwkusWgAoYrAeGA" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="TGZgNrX27EadoaMJE8uUwA" name="SmallIntestine_bc_LowerIleum_bc" description="Neighborhood between Small Intestine/Blood Cells_ and Lower Ileum/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="Tg8zUU7tQUiyXi7TzpD9tA" secondNeighbor="kpS3W3QAK0i25MzZVfuS8g">
+                <Tags>
+                  <Tag value="Neighborhood: BloodCells / BloodCells" />
+                </Tags>
+                <Children>
+                  <Container id="6oK1QsckbUWuczvw3yMGxQ" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="PME72T7wmE6h2ciB_DIEEQ" name="Mass transfer rate (intestine to mucosa blood cells)" description="Mass transfer rate (intestine to mucosa blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="-LQ0WbIoqUKDqM6mBV8yEw" isDefault="1" displayUnit="µmol/min">
+                        <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                      </Parameter>
+                      <Transport id="h6_kSqXTZUipx_D3Z1rR2w" name="MassTransferSINToMucosaBC" description="Mass transfer from Small Intestine:Blood Cells to Mucosa: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="0mex2KMw7kesMYlCsMOFpQ" sourceAmount="40NocQSNtUSnzThV6rVJSA" targetAmount="DaWlSCbKcUag3-1UfyXwhg" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="RiuK9aMN-kCvL4KW4gQusA" name="LowerIleum_pls_PortalVein_pls" description="Neighborhood between Lower Ileum/Plasma and PortalVein/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="9tzwJZOJJ0-AQ1gsdsTzQA" secondNeighbor="s_QiQGLN10Omt7YLmTFwjg">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / Plasma" />
+                </Tags>
+                <Children>
+                  <Container id="3ukjorXfj0Ol4lTDT8xg8A" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="W7jf7GxJ7EGdYCC6YZ35Qw" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="unjGGbbD8EOXmwLo7xca2Q" isDefault="1" displayUnit="µmol/min">
+                        <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                      </Parameter>
+                      <Transport id="0l89EuWgxEiOxK78OYhmow" name="MassTransferMucosaToPvePlasma" description="Mass transfer from Mucosa:Plasma To Portal Vein: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="6h_4ReMBvUyGazgrEIggqQ" sourceAmount="TC5L9nJpwkusWgAoYrAeGA" targetAmount="JvJXBdwv-UOGE6DoopBJuA" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="eMjehpYpQ06iOoH3jJMAKw" name="LowerIleum_bc_PortalVein_bc" description="Neighborhood between Lower Ileum/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="kpS3W3QAK0i25MzZVfuS8g" secondNeighbor="-iUsllv1MkOvPkSoihwHiA">
+                <Tags>
+                  <Tag value="Neighborhood: BloodCells / BloodCells" />
+                </Tags>
+                <Children>
+                  <Container id="XMPjt40g9kCW_84-gt82mQ" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="3S27Iy20pU2655jhJSx8Fw" name="Mass transfer rate (mucosa to portal vein blood cells)" description="Mass transfer rate (mucosa to portal vein blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="9ZNZqpqF706xsve1ZwEePQ" isDefault="1" displayUnit="µmol/min">
+                        <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                      </Parameter>
+                      <Transport id="TevKCKK9V0GkRWO6EfkTcw" name="MassTransferMucosaToPveBC" description="Mass transfer from Mucosa:Blood Cells To Portal Vein: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="Rv4Y7TWcu0KZb4XgGSW1Bw" sourceAmount="DaWlSCbKcUag3-1UfyXwhg" targetAmount="RCAqJaBNgE-vkuaKfPZpnw" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="L4aVfUJOukKJxs2sCsG-WA" name="LargeIntestine_bc_PortalVein_bc" description="Neighborhood between Large Intestine/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="7kXmyJZiGkOucBYhYbZiPg" secondNeighbor="-iUsllv1MkOvPkSoihwHiA">
+                <Tags>
+                  <Tag value="Neighborhood: BloodCells / BloodCells" />
+                </Tags>
+                <Children>
+                  <Container id="8BfVYf6bSUWYdaM5d36bew" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="JNCxAwbTUUSzJWpNIw-5cQ" name="MassTransferLinRBC2BloodPool_Pve" description="Mass transfer from Large Intestine to Portal Vein: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="XiGGoMsEjUiG4szHzDuHmQ" sourceAmount="9rqXdL0WmEOIxAFlIbki9w" targetAmount="RCAqJaBNgE-vkuaKfPZpnw" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="ApYS63tR2UuI0aS5yVVOCA" name="LargeIntestine_int_LargeIntestine_cell" description="Neighborhood between Large Intestine/Interstitial and Large Intestine/Intracellular" mode="Logical" containerType="Neighborhood" firstNeighbor="iMM3BdMgf0Wnvj9e_7Mcmw" secondNeighbor="evrr5qPLqEuNV_jkyn7ckA">
+                <Tags>
+                  <Tag value="Large intestine  neighborhood" />
+                  <Tag value="Neighborhood: Interstitial / Intracellular" />
+                </Tags>
+                <Children>
+                  <Container id="mVBvEd2-tU-gqB0uWyKsJw" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="ygWdnKb7Lk-DjTNt6bvXQg" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="iF9O5xA_e0SIVFmFG1ht8A" isDefault="1" displayUnit="cm/min">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="78" />
+                      </Parameter>
+                      <Parameter id="z2LSNo-P-0WEvMUZLVpm8Q" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="IKrcjT7b50S-hZpXm7B5cQ" isDefault="1" displayUnit="cm/min">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="76" />
+                      </Parameter>
+                      <Parameter id="IRaKO1yrlUGKCGSYeW2lXg" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="M2WXUlVpY0W18PhhdNB88Q" isDefault="1" displayUnit="l/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="nGWWqAjQ7UOlW_DEtyL_5Q" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="70Te4TWLFEi68KKWZ6BTqA" isDefault="1" displayUnit="l/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="YMtMdBJ0nE2Pk_7kMDiXpQ" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="9cod-31mFUKkrQ_7rYq_8A" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="7DZv7k_jV0C4SfVf0pl45A" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="KCOUZrmVTkm7r8v5MO84FQ" isDefault="1">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="69" />
+                      </Parameter>
+                      <Parameter id="J-Z4WZsIkEiEW5njYRIAnA" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cf5OHy-pE0-BjjqyfS_nTg" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+                      </Parameter>
+                      <Parameter id="GDxGThiRk0e3giVEkDREzg" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="casC9bQa6kCW8WuZvRnfQQ" isDefault="1">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Transport id="m-iw9FFpQUieFC86K2ooow" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Transport" dimension="Amount per time" formula="_9nxMMBtdk2LWFeWSKH7mw" sourceAmount="4_rjfMQJO0uUw1Qd8Q2aJQ" targetAmount="FdDQaF-jbEeceFWo0Uq_8Q" />
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+                  <Container id="fgfqJjbHkEGVu6qrJ6EfVg" name="Aciclovir" mode="Logical" containerType="Molecule">
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+                      <Parameter id="Ela-8v_REUmbZB4y33wBow" name="Mass transfer rate (intestine to mucosa blood cells)" description="Mass transfer rate (intestine to mucosa blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="JGqHXOg2ukKcC0NSpHB_Gg" isDefault="1" displayUnit="µmol/min">
+                        <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                      </Parameter>
+                      <Transport id="qKaMkcEOh0eModNUMMuupg" name="MassTransferLINToMucosaBC" description="Mass transfer from Large Intestine:Blood Cells to Mucosa: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="YlFt75YWTU-j4Pnuytg3hA" sourceAmount="9rqXdL0WmEOIxAFlIbki9w" targetAmount="KCragzk5OEWZZOrYQdbBjw" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="RYl5Rpj-HEa9kGfj2bDsow" name="LargeIntestine_pls_Rectum_pls" description="Neighborhood between Large Intestine/Plasma_ and Rectum/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="ktOYgOHeEU6lrdTGt7nwtw" secondNeighbor="0CSP90W06Uu1NGW7pHqKUQ">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / Plasma" />
+                </Tags>
+                <Children>
+                  <Container id="iTyScboimka0TXx-PH69Bw" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="21-XuY2Ja0GHd8zcsvKaJg" name="Mass transfer rate (intestine to mucosa plasma)" description="Mass transfer rate (intestine to mucosa plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="rabvkrEVCU-rI--R9owlCA" isDefault="1" displayUnit="µmol/min">
+                        <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                      </Parameter>
+                      <Transport id="kGzCKSsv1kKMQ7djXkasJA" name="MassTransferLINToMucosaPlasma" description="Mass transfer from Large Intestine:Plasma to Mucosa: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="FrbZz573FkmF6UbNBRLroQ" sourceAmount="egltpUZO6EWeO7Pbo85uvA" targetAmount="8pkBuuXtZUSHRQVga9r96Q" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="N5mP-h-EykCnepp06oHeDQ" name="LargeIntestine_bc_Rectum_bc" description="Neighborhood between Large Intestine/Blood Cells_ and Rectum/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="7kXmyJZiGkOucBYhYbZiPg" secondNeighbor="aeMJUV5deEqPjiwgzRk9Sw">
+                <Tags>
+                  <Tag value="Neighborhood: BloodCells / BloodCells" />
+                </Tags>
+                <Children>
+                  <Container id="NGUHj7fnrEq0KpEvLrRPMQ" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="soRR-ZTf80OSfkMmaUXGDw" name="Mass transfer rate (intestine to mucosa blood cells)" description="Mass transfer rate (intestine to mucosa blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="lM0IHiOL-06AMGGeh6FBOw" isDefault="1" displayUnit="µmol/min">
+                        <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                      </Parameter>
+                      <Transport id="WpePD-qOgEymN7RmHQxoHQ" name="MassTransferLINToMucosaBC" description="Mass transfer from Large Intestine:Blood Cells to Mucosa: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="bg8wm_ZNGEK6ovlgkKdFzA" sourceAmount="9rqXdL0WmEOIxAFlIbki9w" targetAmount="KO0_pqb3mkWfWurFI6aujA" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="HfZAJLY3VEuQrHQ6y7orVw" name="Liver_int_Liver_cell" description="Neighborhood between Liver/Interstitial and Liver/Intracellular" mode="Logical" containerType="Neighborhood" firstNeighbor="K3-RsMPDFUejJYffMtS4LA" secondNeighbor="N63xgAuWWEiV_VrpoG6HtA">
+                <Tags>
+                  <Tag value="Neighborhood: Interstitial / Intracellular" />
+                </Tags>
+                <Children>
+                  <Parameter id="KNnJ1GVHwEmo8M5pp1PUhw" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="tMroMHIeZUeHuch-4Qcb0Q" isDefault="1" displayUnit="cm²">
+                    <Tags>
+                      <Tag value="Neighborhood: Interstitial / Intracellular" />
+                    </Tags>
+                    <Info min="0" flag="122" seq="8" ref="0" bb="32" group="105" />
+                  </Parameter>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="qiyMVBht_U2P7uCSQJ6VGQ" name="Liver_pls_Liver_bc" description="Neighborhood between Liver/Plasma and Liver/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="Qxt7JnIyBE6PQaT-fFYBDA" secondNeighbor="_A2N5wI-mkSOzMFXz2m0RA">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / BloodCells" />
+                </Tags>
+                <Children>
+                  <Parameter id="J8OTeyVqU0mebbSdH-gv4Q" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="yGoZPJmGt0eCJN1vTc9hUQ" isDefault="1" displayUnit="cm²">
+                    <Tags>
+                      <Tag value="Neighborhood: Plasma / BloodCells" />
+                    </Tags>
+                    <Info min="0" flag="122" seq="10" ref="0" bb="32" group="104" />
+                  </Parameter>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="GRyMktTqzE2Uv1tGyV5Z8A" name="Liver_pls_Liver_int" description="Neighborhood between Liver/Plasma and Liver/Interstitial" mode="Logical" containerType="Neighborhood" firstNeighbor="Qxt7JnIyBE6PQaT-fFYBDA" secondNeighbor="K3-RsMPDFUejJYffMtS4LA">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / Interstitial" />
+                </Tags>
+                <Children>
+                  <Parameter id="xBJaUdr3FUy20dKl7_wdWg" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="j4yQtJQFZUurIAIQBLEBkA" isDefault="1" displayUnit="cm²">
+                    <Tags>
+                      <Tag value="Neighborhood: Plasma / Interstitial" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="8" ref="0" bb="32" group="106" />
+                  </Parameter>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="e0Lgd45gjE6t-La2-DXXjQ" name="Gallbladder_Lumen_duo" description="Gallbladder and Lumen/Duodenum" mode="Logical" containerType="Neighborhood" firstNeighbor="0yTaY2gd3UipyrhEBeHPwQ" secondNeighbor="FiXHspIznEeQWrX1VkMsyg">
+                <Tags>
+                  <Tag value="Neighborhood: Gallbladder / Duodenum" />
+                </Tags>
+                <Children>
+                  <Container id="pv0ewiaIPEG0dRxn0n4tfg" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="MjEBJZnXgkOAUeq-FE4rPw" name="GallbladderEmptying" description="Gallbladder emptying" mode="Logical" containerType="Transport" dimension="Amount per time" formula="F9Dz4BPBPkKVR-e3axvnOA" sourceAmount="bvwNErPs6U2pactFp6kebQ" targetAmount="QIs0jmUAIE6ikShycjAOCw" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="X6A2elaeyE2dLOsvnsJfCg" name="Periportal_int_Periportal_cell" description="Neighborhood between Liver/Periportal/Interstitial and Liver/Periportal/Intracellular" mode="Logical" containerType="Neighborhood" firstNeighbor="w7euoHyijUC9nuy9AE5Ivg" secondNeighbor="aIxbxCsVOku2QkfQy3lABw">
+                <Tags>
+                  <Tag value="Neighborhood: Interstitial / Intracellular" />
+                </Tags>
+                <Children>
+                  <Container id="vB5-63C44kelInr3PPTiYQ" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="uU8WQBWVqE-NhaPlnzzxfQ" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="iF9O5xA_e0SIVFmFG1ht8A" isDefault="1" displayUnit="cm/min">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="78" />
+                      </Parameter>
+                      <Parameter id="ZiFqCf0nvEKtig6X3s1t-Q" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="IKrcjT7b50S-hZpXm7B5cQ" isDefault="1" displayUnit="cm/min">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="76" />
+                      </Parameter>
+                      <Parameter id="PydFOoCsrkilS24PH2NoKA" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="M2WXUlVpY0W18PhhdNB88Q" isDefault="1" displayUnit="l/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="m1IOxRubqUabvXwWIlvjOw" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="70Te4TWLFEi68KKWZ6BTqA" isDefault="1" displayUnit="l/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="gmZ_L3E8RkqwBu96Lk7r0g" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="228uwmEhaUyDa8tAKOqRpQ" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="sVfDvnKFBkCHpXP_Nvsghw" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="m9C5rpDpUk2ByE7hwdwMZA" isDefault="1">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="69" />
+                      </Parameter>
+                      <Parameter id="-4jJiaD5AEu3hjU5SafyCg" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cf5OHy-pE0-BjjqyfS_nTg" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+                      </Parameter>
+                      <Parameter id="y6Bb84WFCUyPNMd1KQxOFA" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="e7QLHW8Fnkyy4jigDj1nCQ" isDefault="1">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Transport id="3jnmCElllUesO52D7eh32w" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Transport" dimension="Amount per time" formula="LUW7USaNOUSg650glsU4FQ" sourceAmount="ZmC0ArIIREGqHHncR1JOvA" targetAmount="iguGT0JRWkCNjr7lnacULQ" />
+                    </Children>
+                  </Container>
+                  <Parameter id="ucu-Ky0Yjkis2rohh4EvCw" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="tcchSXoP9ECB9nKBliqxjA" isDefault="1" displayUnit="cm²">
+                    <Tags>
+                      <Tag value="Neighborhood: Interstitial / Intracellular" />
+                    </Tags>
+                    <Info min="0" flag="62" seq="9" ref="0" bb="32" group="105" />
+                  </Parameter>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="hRGlBzhi8ke827QYVflQcA" name="Periportal_pls_Periportal_bc" description="Neighborhood between Liver/Periportal/Plasma and Liver/Periportal/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="MdB187oio0-foD_cFf6VMg" secondNeighbor="p0PJVnbRnk2esgod-s-YpQ">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / BloodCells" />
+                </Tags>
+                <Children>
+                  <Container id="KCpveC4xeUyLbe7r8OqYlg" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="wdRM4Q72uEGWKrJovIrcHg" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="GB1C52NfnEa7l2x4KLHZzA" sourceAmount="S_D_72AW7kC50sVDYbL6kg" targetAmount="q8orlQFozEmoeJ0uL0XwLQ" />
+                    </Children>
+                  </Container>
+                  <Parameter id="xw8Ufis4OUW1a5veNpg1Wg" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="fjC1Z63TI0SCIUme6XHXNA" isDefault="1" displayUnit="cm²">
+                    <Tags>
+                      <Tag value="Neighborhood: Plasma / BloodCells" />
+                    </Tags>
+                    <Info min="0" flag="62" seq="11" ref="0" bb="32" group="104" />
+                  </Parameter>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="E07mZmI0-06dh65K0bsqvQ" name="Periportal_pls_Periportal_int" description="Neighborhood between Liver/Periportal/Plasma and Liver/Periportal/Interstitial" mode="Logical" containerType="Neighborhood" firstNeighbor="MdB187oio0-foD_cFf6VMg" secondNeighbor="w7euoHyijUC9nuy9AE5Ivg">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / Interstitial" />
+                </Tags>
+                <Children>
+                  <Container id="qgttzj9dLkiatobTs2qjbw" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="V3priqSLqESPzJu1lq7L6g" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
+                        <ValueOrigin id="49" source="Other" method="Assumption" description="Assumption: very fast exchange" />
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="77" />
+                      </Parameter>
+                      <Parameter id="aDgMrQTSok6l-8AUGCK8Gw" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="WO-8Vog5vUuNvOpjrIOoOg" isDefault="1">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="70" />
+                      </Parameter>
+                      <Transport id="ZrPkd3z5Lkavb7Cjk6mrQQ" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Transport" dimension="Amount per time" formula="SxswYcSFqES3uMs7q41cbQ" sourceAmount="S_D_72AW7kC50sVDYbL6kg" targetAmount="ZmC0ArIIREGqHHncR1JOvA" />
+                    </Children>
+                  </Container>
+                  <Parameter id="aOTVS5TnkUugjgsXjet5aw" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SV1DwoW5QEmUskZc08ZGpQ" isDefault="1" displayUnit="cm²">
+                    <Tags>
+                      <Tag value="Neighborhood: Plasma / Interstitial" />
+                    </Tags>
+                    <Info min="0" flag="62" seq="9" ref="0" bb="32" group="106" />
+                  </Parameter>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="TW5EPBWFhkCuRBqXhsrEGA" name="Pericentral_int_Pericentral_cell" description="Neighborhood between Liver/Pericentral/Interstitial and Liver/Pericentral/Intracellular" mode="Logical" containerType="Neighborhood" firstNeighbor="j-YCxKWZHEaglMpn96BfnA" secondNeighbor="-LvKeSAYSkGcwROyAj_Blg">
+                <Tags>
+                  <Tag value="Neighborhood: Interstitial / Intracellular" />
+                </Tags>
+                <Children>
+                  <Container id="2_A7ZcvLckG6mnjmgubmBg" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="uXSMPTeW5kegLiACuazeLQ" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="iF9O5xA_e0SIVFmFG1ht8A" isDefault="1" displayUnit="cm/min">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="78" />
+                      </Parameter>
+                      <Parameter id="nlmwdCeQhEqAsx8pLSkp1g" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="IKrcjT7b50S-hZpXm7B5cQ" isDefault="1" displayUnit="cm/min">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="76" />
+                      </Parameter>
+                      <Parameter id="-rTktiRfOkWZIPk7C7lYuA" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="M2WXUlVpY0W18PhhdNB88Q" isDefault="1" displayUnit="l/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="qGXZFggb-06uSorFEpJj8Q" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="70Te4TWLFEi68KKWZ6BTqA" isDefault="1" displayUnit="l/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="k4vRvOQ9ykqib-lCiOBjXw" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="9DlxNJlPeEaLnozXLfn9LQ" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="t1XI3YQg2EGYIZlIcvU0Lw" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="SO1F3oaU2UK3NGYIgrP0RQ" isDefault="1">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="69" />
+                      </Parameter>
+                      <Parameter id="thlaSoqsOEa4vOZBgDTCrA" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cf5OHy-pE0-BjjqyfS_nTg" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+                      </Parameter>
+                      <Parameter id="rqsNdHZ95UO-ZKGQGo42JA" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="FD6R_oZE40umQqbhOLAISg" isDefault="1">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Transport id="Kr25nsK__kCd_4CfxTTaNA" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Transport" dimension="Amount per time" formula="Ds8HMlz_30qLdLkiO4PS5A" sourceAmount="evFzmKAMy0ajzy8DDAy9cQ" targetAmount="CKiTLFdTE0G-fsuf1Ajuvw" />
+                    </Children>
+                  </Container>
+                  <Parameter id="mGGeqCyR_UuJ8qskRU7Xkw" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="NRgoVeQQcEGNutSktOWo3w" isDefault="1" displayUnit="cm²">
+                    <Tags>
+                      <Tag value="Neighborhood: Interstitial / Intracellular" />
+                    </Tags>
+                    <Info min="0" flag="62" seq="10" ref="0" bb="32" group="105" />
+                  </Parameter>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="MPNpUERQz0CRJf42_cWFqQ" name="Pericentral_pls_Pericentral_bc" description="Neighborhood between Liver/Pericentral/Plasma and Liver/Pericentral/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="nMmv0kFQ_kWYQzIhWEinuQ" secondNeighbor="hdm7_1fsfUmYOyYmPmNQ-A">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / BloodCells" />
+                </Tags>
+                <Children>
+                  <Container id="-ob1Oo5LvEKCGuUf0HsVJA" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="a_6QiP_GmUWILsEb3Mchcg" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="KkIrEzuxQ0CVUk8kGCbLfg" sourceAmount="as_T4ZrleUmCMyQ2xi_8gQ" targetAmount="kjr24I7cNk6rkfnQhZPKzA" />
+                    </Children>
+                  </Container>
+                  <Parameter id="7LzUTLaFmUCEzH0hwU3Lvw" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="sswP7khtQkOBCSu9Cflfng" isDefault="1" displayUnit="cm²">
+                    <Tags>
+                      <Tag value="Neighborhood: Plasma / BloodCells" />
+                    </Tags>
+                    <Info min="0" flag="62" seq="12" ref="0" bb="32" group="104" />
+                  </Parameter>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="oVm27Lx2CkG_nCV5-S2aXg" name="Pericentral_pls_Pericentral_int" description="Neighborhood between Liver/Pericentral/Plasma and Liver/Pericentral/Interstitial" mode="Logical" containerType="Neighborhood" firstNeighbor="nMmv0kFQ_kWYQzIhWEinuQ" secondNeighbor="j-YCxKWZHEaglMpn96BfnA">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / Interstitial" />
+                </Tags>
+                <Children>
+                  <Container id="9J2wlkkh4UmkQ-59Bl0rAQ" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="I0piXtglBk6jFHXFjMXdXw" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
+                        <ValueOrigin id="49" source="Other" method="Assumption" description="Assumption: very fast exchange" />
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="77" />
+                      </Parameter>
+                      <Parameter id="_k1TygYz7USPflDy1j2ZSQ" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="WO-8Vog5vUuNvOpjrIOoOg" isDefault="1">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="70" />
+                      </Parameter>
+                      <Transport id="KVypcH_fN0m8pFyWDkX8kg" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Transport" dimension="Amount per time" formula="_g-u_VSTVkuQLOLBwma-Cg" sourceAmount="as_T4ZrleUmCMyQ2xi_8gQ" targetAmount="evFzmKAMy0ajzy8DDAy9cQ" />
+                    </Children>
+                  </Container>
+                  <Parameter id="3gI-_8PO1Uqu3hzcyESbfA" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="a1mMUUsec0y8GCYFmYsJDQ" isDefault="1" displayUnit="cm²">
+                    <Tags>
+                      <Tag value="Neighborhood: Plasma / Interstitial" />
+                    </Tags>
+                    <Info min="0" flag="62" seq="10" ref="0" bb="32" group="106" />
+                  </Parameter>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="RB4Pt5lMeUWDqKiBg446nw" name="Lung_bc_ArterialBlood_bc" description="Neighborhood between Lung/Blood Cells and Arterial Blood/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="1ZY_zvMXA0GuV8WaXkkXmg" secondNeighbor="FtxmOVy3hEyMCuullB4l-A">
+                <Tags>
+                  <Tag value="Neighborhood: BloodCells / BloodCells" />
+                </Tags>
+                <Children>
+                  <Container id="XxRKv-3BRkq_Sx59Q_hNhg" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="-j33FbvgA0qBpVY2WWAeTg" name="MassTransferOrgRBC2BloodPool_Lng" description="Mass transfer from Lung: Blood Cells to Arterial Blood: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="wU9X11iFSE2ft9Ozf72B6Q" sourceAmount="ip5plRmlSUqkvy2j2c7QTw" targetAmount="gVpumttaHUG12bviSHchzw" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="VV5y6YX08Eeu_1PYvqlyJA" name="Lung_int_Lung_cell" description="Neighborhood between Lung/Interstitial and Lung/Intracellular" mode="Logical" containerType="Neighborhood" firstNeighbor="07oroyUkA06NRXtnPzAjTw" secondNeighbor="qdkEHfQ76EqWoISIaETCsQ">
+                <Tags>
+                  <Tag value="Neighborhood: Interstitial / Intracellular" />
+                </Tags>
+                <Children>
+                  <Container id="6dXYqinn3EGJzLpAyHkg7A" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="RtqLsxUl60qQl4knv5nB6w" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="iF9O5xA_e0SIVFmFG1ht8A" isDefault="1" displayUnit="cm/min">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="78" />
+                      </Parameter>
+                      <Parameter id="APshmPHHmkSnETvDOK4koQ" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="IKrcjT7b50S-hZpXm7B5cQ" isDefault="1" displayUnit="cm/min">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="76" />
+                      </Parameter>
+                      <Parameter id="sIbSy7acmEOF-AWpH6Jzbw" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="M2WXUlVpY0W18PhhdNB88Q" isDefault="1" displayUnit="l/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="qBAmDaMKn06yZP5GrmxSOg" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="70Te4TWLFEi68KKWZ6BTqA" isDefault="1" displayUnit="l/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="s-VXtPFIbES3pouLJZ31IQ" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="2JNREO9l0UySZmK60sn99A" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="aimaP4TeN0yLuOTMumzcPw" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="LSs8_knbjk6QqHkM7RJB2Q" isDefault="1">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="69" />
+                      </Parameter>
+                      <Parameter id="75A25JuqVkK0FVHm7kM4xw" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cf5OHy-pE0-BjjqyfS_nTg" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+                      </Parameter>
+                      <Parameter id="RCdn1Auo80qklRFQLyARpA" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="N0sgZbfIrUiIB4QIlPJhvg" isDefault="1">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Transport id="sAA81Qd_PEKUYtlQ-uq9YQ" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Transport" dimension="Amount per time" formula="L0seGxCHC0ajEgC3cpRBHQ" sourceAmount="1QJ43jfq9kCsAzesM7eKpw" targetAmount="XnvVEFGAPkmc_vArBjLIMg" />
+                    </Children>
+                  </Container>
+                  <Parameter id="_u0zpcVxzkycLdCTNBSINA" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="u52nFwsWP0irHZOY_xkceA" isDefault="1" displayUnit="cm²">
+                    <Tags>
+                      <Tag value="Neighborhood: Interstitial / Intracellular" />
+                    </Tags>
+                    <Info min="0" flag="122" seq="11" ref="0" bb="32" group="105" />
+                  </Parameter>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="f3sQGs1_EkeDJu-62skFQA" name="Lung_pls_ArterialBlood_pls" description="Neighborhood between Lung/Plasma and Arterial Blood/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="HTpABK8mZ0aLnKny1tA6pA" secondNeighbor="J4LFcXm4AkGl5yqJ_iZoPA">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / Plasma" />
+                </Tags>
+                <Children>
+                  <Container id="JcyzRdFz-EOpJn7Hyt43fA" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="EoMPXYPVPEuyOf0dMmQEAg" name="MassTransferOrgPl2BloodPool_Lng" description="Mass transfer from Lung: Plasma to Arterial Blood: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="wK1TugBtG0isBuUD1-ccFA" sourceAmount="7iG01UndskeLwYVQ2Lt8kw" targetAmount="Ms-OmcTJtEOdeIHT6btWvg" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="gTb-9DGRY0qN5OISHaWelw" name="Lung_pls_Lung_bc" description="Neighborhood between Lung/Plasma and Lung/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="HTpABK8mZ0aLnKny1tA6pA" secondNeighbor="1ZY_zvMXA0GuV8WaXkkXmg">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / BloodCells" />
+                </Tags>
+                <Children>
+                  <Container id="LBa-7Bsi70CmsfARkntJuw" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="xPv7uM47K0WQ1XyKn5MBXg" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="VBIpFTy270WlUBmWtpPz5Q" sourceAmount="7iG01UndskeLwYVQ2Lt8kw" targetAmount="ip5plRmlSUqkvy2j2c7QTw" />
+                    </Children>
+                  </Container>
+                  <Parameter id="oZHNVT2XkUKC4eri49roAA" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="ARgTslmD_k6Z_dL_T5XuyQ" isDefault="1" displayUnit="cm²">
+                    <Tags>
+                      <Tag value="Neighborhood: Plasma / BloodCells" />
+                    </Tags>
+                    <Info min="0" flag="122" seq="13" ref="0" bb="32" group="104" />
+                  </Parameter>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="5RHgFrB8xEGpzrATTs39DQ" name="Lung_pls_Lung_int" description="Neighborhood between Lung/Plasma and Lung/Interstitial" mode="Logical" containerType="Neighborhood" firstNeighbor="HTpABK8mZ0aLnKny1tA6pA" secondNeighbor="07oroyUkA06NRXtnPzAjTw">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / Interstitial" />
+                </Tags>
+                <Children>
+                  <Container id="FBH_rzI_q0ax37bXUDNVhA" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="nKbkf4HcV0GDD-jSm-5PrQ" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
+                        <ValueOrigin id="49" source="Other" method="Assumption" description="Assumption: very fast exchange" />
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="77" />
+                      </Parameter>
+                      <Parameter id="v_SbvjRtbkWA-Z-fDOZB0g" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="WO-8Vog5vUuNvOpjrIOoOg" isDefault="1">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="70" />
+                      </Parameter>
+                      <Transport id="X4YjjcY4tkici2RqzZEAPA" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Transport" dimension="Amount per time" formula="QB1SDwOLzEmTDa4hqOUIMA" sourceAmount="7iG01UndskeLwYVQ2Lt8kw" targetAmount="1QJ43jfq9kCsAzesM7eKpw" />
+                    </Children>
+                  </Container>
+                  <Parameter id="DKqEnFxU1ECecV4kAl2gSA" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Jh8N841QeE6Z4mFZvuQ01Q" isDefault="1" displayUnit="cm²">
+                    <Tags>
+                      <Tag value="Neighborhood: Plasma / Interstitial" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="11" ref="0" bb="32" group="106" />
+                  </Parameter>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="R3QVAU5ujkyR1tgQQp8KbQ" name="Muscle_bc_VenousBlood_bc" description="Neighborhood between Muscle/Blood Cells and Venous Blood/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="YrNyyl3qek2c21v3mmypBA" secondNeighbor="9pDSL8Nq0US2M-Z4-4NiNw">
+                <Tags>
+                  <Tag value="Neighborhood: BloodCells / BloodCells" />
+                </Tags>
+                <Children>
+                  <Container id="kQ7WEER59UmP6VwkyZK9nQ" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="Wpcf_N3Ubk6RB8yhADXZqg" name="MassTransferOrgRBC2BloodPool" description="Mass transfer from organ: Blood Cells to Arterial Blood: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="q6rZxQsLbEyACYRvYS5EeQ" sourceAmount="1uMkucpciUqb_M1_slAxbg" targetAmount="C5df-rtR9kqsgkV4ZWZUKg" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="Su7clmNTS0yte_Z5zVKxnQ" name="Muscle_int_Muscle_cell" description="Neighborhood between Muscle/Interstitial and Muscle/Intracellular" mode="Logical" containerType="Neighborhood" firstNeighbor="OH-vZSELEUyp9mDI8Zq3Xw" secondNeighbor="PUFT_Rx-L0qXs1RoNWy8Kg">
+                <Tags>
+                  <Tag value="Neighborhood: Interstitial / Intracellular" />
+                </Tags>
+                <Children>
+                  <Container id="h2yTtjSAUUC_kvbn-uWrTg" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="p45xNc6d-kOvNB6hDVhgUA" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="iF9O5xA_e0SIVFmFG1ht8A" isDefault="1" displayUnit="cm/min">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="78" />
+                      </Parameter>
+                      <Parameter id="HLVGvuugCUSypETedYMb5Q" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="IKrcjT7b50S-hZpXm7B5cQ" isDefault="1" displayUnit="cm/min">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="76" />
+                      </Parameter>
+                      <Parameter id="LCEcoaE9zUKGERJWAJgerw" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="M2WXUlVpY0W18PhhdNB88Q" isDefault="1" displayUnit="l/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="jza6PhqPiECg15RcZOiHaQ" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="70Te4TWLFEi68KKWZ6BTqA" isDefault="1" displayUnit="l/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="FkoJY1FygUWm1nZ3WIZ5PA" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="qxusxQ4W-EGV2lzM4OoZzw" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="UtfxXYJZr0Ww35Q3rfVJ6g" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="eb6v5T5WnkOeGrnlxxsfmQ" isDefault="1">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="69" />
+                      </Parameter>
+                      <Parameter id="Ga_JdPAyFEWW1vSGS2C-KQ" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cf5OHy-pE0-BjjqyfS_nTg" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+                      </Parameter>
+                      <Parameter id="wFfekVx_x0iSUgTVL2MO6A" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="2TnWvsMqyEuVVzxRs4iRpg" isDefault="1">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Transport id="TUAJ0xyfukq17dsWQCsTCw" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Transport" dimension="Amount per time" formula="c7P-xmMed0iy-dYaCsJ7ow" sourceAmount="tia5cEbIpEuME7LoZw6CFA" targetAmount="YOBh6JO72U-D7HyHLSvVsg" />
+                    </Children>
+                  </Container>
+                  <Parameter id="c2jdtbfDyUuwvUZ31zXJtA" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="D2MDTRnPM0aVvC0jki1XYQ" isDefault="1" displayUnit="cm²">
+                    <Tags>
+                      <Tag value="Neighborhood: Interstitial / Intracellular" />
+                    </Tags>
+                    <Info min="0" flag="122" seq="12" ref="0" bb="32" group="105" />
+                  </Parameter>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="Cr-8YyudkEutaUbvJT6KcQ" name="Muscle_pls_Muscle_bc" description="Neighborhood between Muscle/Plasma and Muscle/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="QuubSGLj2kWxXZwVnyWwJA" secondNeighbor="YrNyyl3qek2c21v3mmypBA">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / BloodCells" />
+                </Tags>
+                <Children>
+                  <Container id="AVafCP2rT0-l8ZiIkTq6Uw" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="IJz7Hmq8M0CrT-wYTdCLow" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="Hn3jWLxjkEWBQpt5qNS7Vg" sourceAmount="bO7yYOOyBEiA8uil4vPbiw" targetAmount="1uMkucpciUqb_M1_slAxbg" />
+                    </Children>
+                  </Container>
+                  <Parameter id="WMtOW_d4l0mIJ0-PPcYkzQ" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="vSVqDbAX00yM2QMn_OcBWQ" isDefault="1" displayUnit="cm²">
+                    <Tags>
+                      <Tag value="Neighborhood: Plasma / BloodCells" />
+                    </Tags>
+                    <Info min="0" flag="122" seq="14" ref="0" bb="32" group="104" />
+                  </Parameter>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="gnvyyPVcNEuyD5Byl1zd_g" name="Muscle_pls_Muscle_int" description="Neighborhood between Muscle/Plasma and Muscle/Interstitial" mode="Logical" containerType="Neighborhood" firstNeighbor="QuubSGLj2kWxXZwVnyWwJA" secondNeighbor="OH-vZSELEUyp9mDI8Zq3Xw">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / Interstitial" />
+                </Tags>
+                <Children>
+                  <Container id="3i_nN8F9x062pfOinlld7Q" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="vkdrWmKI50mcqNhcr139Cw" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
+                        <ValueOrigin id="49" source="Other" method="Assumption" description="Assumption: very fast exchange" />
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="77" />
+                      </Parameter>
+                      <Parameter id="phdQCIWhD0mT2GUNh3I-fg" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="WO-8Vog5vUuNvOpjrIOoOg" isDefault="1">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="70" />
+                      </Parameter>
+                      <Transport id="KnwvE_7SQUi2oxM2j6f41Q" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Transport" dimension="Amount per time" formula="udukQ9gXUkCiKmR_geW9pA" sourceAmount="bO7yYOOyBEiA8uil4vPbiw" targetAmount="tia5cEbIpEuME7LoZw6CFA" />
+                    </Children>
+                  </Container>
+                  <Parameter id="ijHDhrWv5UmgyJaBElo5Yg" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="-GvTWyQqB0GpLqvwN-L1wg" isDefault="1" displayUnit="cm²">
+                    <Tags>
+                      <Tag value="Neighborhood: Plasma / Interstitial" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="12" ref="0" bb="32" group="106" />
+                  </Parameter>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="eRcXb-X1AE6bbN0gwrY5-A" name="Muscle_pls_VenousBlood_pls" description="Neighborhood between Muscle/Plasma and Venous Blood/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="QuubSGLj2kWxXZwVnyWwJA" secondNeighbor="7Skx_VpY1kGT74Rns_5puw">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / Plasma" />
+                </Tags>
+                <Children>
+                  <Container id="xSRXAuypUk-UXjhHYsRzFw" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="X5UPk59tuUmgb9H5AfLxgQ" name="MassTransferOrgPl2BloodPool" description="Mass transfer from organ: Plasma to Venous Blood: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="bSXFHZLKMUSBYHVaXsP73Q" sourceAmount="bO7yYOOyBEiA8uil4vPbiw" targetAmount="7Rbeovs3_k-ueQGXqYkAXw" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="vjxaXW7MZUaZcNWwh_x9Qg" name="Pancreas_bc_PortalVein_bc" description="Neighborhood between Pancreas/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="i_uU7NwDCEeD0Ik1qMIqWA" secondNeighbor="-iUsllv1MkOvPkSoihwHiA">
+                <Tags>
+                  <Tag value="Neighborhood: BloodCells / BloodCells" />
+                </Tags>
+                <Children>
+                  <Container id="8h-Mq47UtkCHnuBPRqChNw" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="t9UhFNCHJ0aicJzdfUQ3yw" name="MassTransferOrgRBC2BloodPool_Pve" description="Mass transfer from organ: Blood Cells to Portal Vein: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="r2OhKVzHB0msumwc-xf-bA" sourceAmount="_HDgRru2E06JCk8r7x3RxQ" targetAmount="RCAqJaBNgE-vkuaKfPZpnw" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="8Lv6QfqSZUmk5WALZxu2lQ" name="Pancreas_int_Pancreas_cell" description="Neighborhood between Pancreas/Interstitial and Pancreas/Intracellular" mode="Logical" containerType="Neighborhood" firstNeighbor="Z0CRYbh2QUeAR4arnWTxbw" secondNeighbor="BClYRueZp06iCi1tM2qFwA">
+                <Tags>
+                  <Tag value="Neighborhood: Interstitial / Intracellular" />
+                </Tags>
+                <Children>
+                  <Container id="K2C9qCF8mUym5SdFkQhqhA" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="_SSdbBJBY06VvZr4eTS52A" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="iF9O5xA_e0SIVFmFG1ht8A" isDefault="1" displayUnit="cm/min">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="78" />
+                      </Parameter>
+                      <Parameter id="He218Ge87UGBVtEzAF1E9Q" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="IKrcjT7b50S-hZpXm7B5cQ" isDefault="1" displayUnit="cm/min">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="76" />
+                      </Parameter>
+                      <Parameter id="uEy9bwgPbU-gTeFPM-Fp2w" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="M2WXUlVpY0W18PhhdNB88Q" isDefault="1" displayUnit="l/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="_9mP0MUSRkaI-u5wrx5Y-Q" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="70Te4TWLFEi68KKWZ6BTqA" isDefault="1" displayUnit="l/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="usThMwPK1ECk0FZy8IIVbQ" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="5z9hHvL13Ee0IgYvQWcNJg" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="Bh8mlsdAmU6APblOb_rsEQ" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="dcr_666xQE6q2ONifeNXbA" isDefault="1">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="69" />
+                      </Parameter>
+                      <Parameter id="kcO7H9c3vEeyj9ngmB6uEQ" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cf5OHy-pE0-BjjqyfS_nTg" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+                      </Parameter>
+                      <Parameter id="8ppAvdHHz0OLdBkbiCGwPQ" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="xbiwcJatf0WBm8kdK3neCA" isDefault="1">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Transport id="dgeGoACM4EGFZsVMpcZrjQ" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Transport" dimension="Amount per time" formula="objDOlU6mUOEup60-CSj0A" sourceAmount="5Wetv1Vy1k-NKhVMgxE8mg" targetAmount="_tPHvEdkHEmc8tryrjj7lQ" />
+                    </Children>
+                  </Container>
+                  <Parameter id="3g1tVzqTNUmCgEhFyQFPCQ" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="NjC0F0NRz0GehzCwE6pnZA" isDefault="1" displayUnit="cm²">
+                    <Tags>
+                      <Tag value="Neighborhood: Interstitial / Intracellular" />
+                    </Tags>
+                    <Info min="0" flag="122" seq="13" ref="0" bb="32" group="105" />
+                  </Parameter>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="s1tp45TcUki9hPgHyVIr2A" name="Pancreas_pls_Pancreas_bc" description="Neighborhood between Pancreas/Plasma and Pancreas/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="5C6Dv04n9EGG4vtDsR-UpQ" secondNeighbor="i_uU7NwDCEeD0Ik1qMIqWA">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / BloodCells" />
+                </Tags>
+                <Children>
+                  <Container id="-wyCh36yGU-crU0--aNRmQ" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="mnK6WbWNu02ZgBZ_gI5jiA" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="Jnxi_Y6QWE-yBBTjwYhwOw" sourceAmount="AdODwmUjQk69oFXjb-S1SA" targetAmount="_HDgRru2E06JCk8r7x3RxQ" />
+                    </Children>
+                  </Container>
+                  <Parameter id="_i-VI65CZEKx0d_JK7amSg" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="raVoIo8flUec5FgePlx7uA" isDefault="1" displayUnit="cm²">
+                    <Tags>
+                      <Tag value="Neighborhood: Plasma / BloodCells" />
+                    </Tags>
+                    <Info min="0" flag="122" seq="15" ref="0" bb="32" group="104" />
+                  </Parameter>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="WmBdkfdZyUKbHfqUYxjbyA" name="Pancreas_pls_Pancreas_int" description="Neighborhood between Pancreas/Plasma and Pancreas/Interstitial" mode="Logical" containerType="Neighborhood" firstNeighbor="5C6Dv04n9EGG4vtDsR-UpQ" secondNeighbor="Z0CRYbh2QUeAR4arnWTxbw">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / Interstitial" />
+                </Tags>
+                <Children>
+                  <Container id="-vQnIm4110aBXGb054yhtg" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="TkBnhx0_MkO2jRfn2mqQeA" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
+                        <ValueOrigin id="49" source="Other" method="Assumption" description="Assumption: very fast exchange" />
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="77" />
+                      </Parameter>
+                      <Parameter id="qAMo1BfoYkGEnvrnJe9y6w" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="WO-8Vog5vUuNvOpjrIOoOg" isDefault="1">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="70" />
+                      </Parameter>
+                      <Transport id="C8pqiBXU0Eyzs4-dgiaTeg" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Transport" dimension="Amount per time" formula="Qc23Fs9lv0W_AdyFMNwDMQ" sourceAmount="AdODwmUjQk69oFXjb-S1SA" targetAmount="5Wetv1Vy1k-NKhVMgxE8mg" />
+                    </Children>
+                  </Container>
+                  <Parameter id="HDhx0M43b0mtjbDRrPQM0g" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="ZxyPYRHSh0ef4r3V80ufpg" isDefault="1" displayUnit="cm²">
+                    <Tags>
+                      <Tag value="Neighborhood: Plasma / Interstitial" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="13" ref="0" bb="32" group="106" />
+                  </Parameter>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="jdiJaEMHnEKtQAWqXi1RaA" name="Pancreas_pls_PortalVein_pls" description="Neighborhood between Pancreas/Plasma and PortalVein/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="5C6Dv04n9EGG4vtDsR-UpQ" secondNeighbor="s_QiQGLN10Omt7YLmTFwjg">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / Plasma" />
+                </Tags>
+                <Children>
+                  <Container id="DU5zv-YjU0eSsen6z1ramw" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="L3j9M9IirUOy7lx4TroYTg" name="MassTransferOrgPl2BloodPool_pve" description="Mass transfer from organ: Plasma to Portal Vein: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="I2O9sjdSXUGeCaXAUNnx8Q" sourceAmount="AdODwmUjQk69oFXjb-S1SA" targetAmount="JvJXBdwv-UOGE6DoopBJuA" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="0ir202RqLUCKlRfyDWIVFA" name="Lumen_rect_Rectum_pls" description="Neighborhood between Lumen/Rectum and Mucosa/Rectum/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="jUxouOhem0ep-Qu6MPS_aw" secondNeighbor="0CSP90W06Uu1NGW7pHqKUQ">
+                <Tags>
+                  <Tag value="Neighborhood: Rectum / Plasma" />
+                </Tags>
+                <Children>
+                  <Container id="K0tWUwaLZEiMk5smB1hkLA" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="k2uWaAc0SUmu7SrGLp2h0Q" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="QcXkUC4ra0mBDOlGLNwtrg" isDefault="1" displayUnit="µmol/min">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                      </Parameter>
+                      <Parameter id="WBs3YPLF70-aJjskeQsh7w" name="Sum of active process rates" description="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="dA5-CfGBAEGpnbUiCyEiAA" isDefault="1" displayUnit="µmol/min">
+                        <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="ycljVC7NMUOjXtegsqfqgA" name="Sum of passive process rates" description="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="38ec0gJIl0uw0C1eSnlxTQ" isDefault="1" displayUnit="µmol/min">
+                        <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="ycaw7MgM8ESityk-De58Zg" name="Lumen_rect_Rectum_cell" description="Neighborhood between Lumen/Rectum and Mucosa/Rectum/Intracellular" mode="Logical" containerType="Neighborhood" firstNeighbor="jUxouOhem0ep-Qu6MPS_aw" secondNeighbor="FM81ONq2DEuyLvEEZVywLg">
+                <Tags>
+                  <Tag value="Neighborhood: Rectum / Intracellular" />
+                </Tags>
+                <Children>
+                  <Container id="bgo7KcMvg0Ss8xIDn-truA" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="oFrobLm57kyyTy7jomY_kw" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="qLc3gTO7TUqDvhpj1yVBag" isDefault="1" displayUnit="µmol/min">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                      </Parameter>
+                      <Parameter id="Wmhpl20X3UW5FIm209glpA" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="3y6-m8wgOEKD3GtEjz0zzg" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="-0qx9aoZaESyFMYx0Jlz5g" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="lJ91Y9prMU-IAOmp8VeUZA" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="s9r5vIPaCEuzcxafgnpAqQ" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="NFMc2OgnRk6qHYYVPCcuYw" isDefault="1">
+                        <Info min="0" flag="36" seq="1" ref="0" bb="2" group="67" />
+                      </Parameter>
+                      <Parameter id="HT9w3P75-UGXRIYKWpCRlQ" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Wh5wzf-mPUycV40RpU6SmA" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+                      </Parameter>
+                      <Parameter id="gknnLVq-skmZ9xSmG18rqQ" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="pVsh-86jOE2jZ8dZUPQscQ" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="6sWWvUdzvUK2Wb8V_oDMLw" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="eESC_ReEwk6KDcP-7OhV0A" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="0oKKg2ecPUSQFlbdrPf0DA" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="yz-mGnS7M0mR5_598pOwSg" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="fULe3p4SKkSuOlPMLaim5Q" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="lfuixO3kjEW_DgVwm-NEkA" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="AZshu-xtN0Sjx7PbCSqW2Q" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="wpZOWtsCVEivIawZ0cJTQQ" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="K8uXzQCAk0u6Fn_nQNmJ1A" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="zDjvv8qD_0q6sFClKz_6Dw" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="zwtJ6F2lRkK9a6PAcYhE1w" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IIYsrx_Fhkm3HVhCSgi4JA" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="MZSHMZ2Bh0KFYdN-wGtnNg" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="unqtYV5AeEOgOCuJHP2VSA" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="pUYRqT-AiEWw9sCmF0yZiQ" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="bpZDuWciwU2LDzUNVjrx2A" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="fb44kqrtKEWg_AK9V9I_Jw" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="WlVW33RvI0izDWhDdH2ACw" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="NfiflS8VH0GyDTAGEG6VpQ" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="lZaz3UUV6EeQOunL9WZ4_g" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="u_0s3NRKn0yskoUUvbgnfg" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="9INkZ_sfq0e_ci_-MmsTQA" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="kpfSixzbFUeiEDSIWcGuNw" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="lDNp_OEVzEOsWIJeobxJdQ" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="UVT_bcUUSkObpmEri26wjg" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="mNxsa8NPT0ySxqWymD1B5A" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="I7ZPgBMKNEyJxEWVYD25rQ" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="5JG_BBjIek6qnerxqqbp5A" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="mFx1h0oqLE6pdeXzaehPDA" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="9Avqn_lfmkOYWTl8-_rMmg" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="ZcW_8rPxcEi2ohT_tFuibg" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ucHi0vXPN0WPpok-4cCWCQ" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="EbJKmU-ZAkmaeCMe151--Q" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Q7JAceEGmkCCiLcIdSgVFg" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="4dD91CnvYEqMEdYpg0uPJg" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cg3-HM5rEkyKAe6nt4Tgnw" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="4uFuVUHKwUGO30izFY9hbw" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="rI_XOwPh-kSUkyS48tdLCw" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="QfrPDxNK6Umrc_g_AxFJjQ" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="2MsqcDgQ9kWp8tSdr6OMJQ" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="yphIfemYa0KFP5VreArV4w" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="fRQlUllt4kGqcKWlmlGP7g" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="-G7D_VsEW0mraK-X7eGznA" name="Sum of active process rates" description="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="4hOpqm54mEOhjfG1pmwT7Q" isDefault="1" displayUnit="µmol/min">
+                        <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="56UUWn7JVkiDctbSmxCVww" name="Sum of passive process rates" description="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="oYexu9XvvUWwB4fJd0e5ag" isDefault="1" displayUnit="µmol/min">
+                        <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Transport id="o2JSH0TnfkqpSls4Cqg1sQ" name="DrugAbsorption_trans" description="Drug absorption transcellular" mode="Logical" containerType="Transport" dimension="Amount per time" formula="7JdCbl31IEmi5zXmdBpk8w" sourceAmount="jMO_rCAwBkWG0LU4CcM-ew" targetAmount="IXiI7k4TAkiRJ08hJByC7A">
+                        <Children>
+                          <Parameter id="s4WveFxNzkKStsGih8sXAQ" name="ProcessRate" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="7fe5078zQEiuXvjIm9SQRQ" isDefault="1" displayUnit="µmol/min">
+                            <Tags>
+                              <Tag value="DrugAbsorption_trans" />
+                              <Tag value="ProcessRate" />
+                              <Tag value="Aciclovir" />
+                              <Tag value="Lumen_rect_Rectum_cell" />
+                              <Tag value="Passive" />
+                            </Tags>
+                            <Info flag="6" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                        </Children>
+                      </Transport>
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="Eu-7sGE1gUGqR5duaCTcLQ" name="Rectum_pls_PortalVein_pls" description="Neighborhood between Rectum/Plasma and PortalVein/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="0CSP90W06Uu1NGW7pHqKUQ" secondNeighbor="s_QiQGLN10Omt7YLmTFwjg">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / Plasma" />
+                </Tags>
+                <Children>
+                  <Container id="yRWQ5yTCj0uYg_fFN42GQg" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="xaSD4miMaEyfwcEs0Xw_xA" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="bzvJme-JjkOMdOvtU9FFvg" isDefault="1" displayUnit="µmol/min">
+                        <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                      </Parameter>
+                      <Transport id="xrj71Pzt1UqOXFJVyT2l_g" name="MassTransferMucosaToPvePlasma" description="Mass transfer from Mucosa:Plasma To Portal Vein: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="6jJ2dnMpnEyw4SxjbqE5mw" sourceAmount="8pkBuuXtZUSHRQVga9r96Q" targetAmount="JvJXBdwv-UOGE6DoopBJuA" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="OGeqvMTWFkOjCiggJ3Ovyw" name="Rectum_bc_PortalVein_bc" description="Neighborhood between Rectum/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="aeMJUV5deEqPjiwgzRk9Sw" secondNeighbor="-iUsllv1MkOvPkSoihwHiA">
+                <Tags>
+                  <Tag value="Neighborhood: BloodCells / BloodCells" />
+                </Tags>
+                <Children>
+                  <Container id="VYiNL001x0-c2jBgzarLSw" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="m9NC6f54oUmMUfAKr5D64w" name="Mass transfer rate (mucosa to portal vein blood cells)" description="Mass transfer rate (mucosa to portal vein blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="C2cqpJYOxUiD_7T8Ixdv2g" isDefault="1" displayUnit="µmol/min">
+                        <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                      </Parameter>
+                      <Transport id="ctrIOeHLu06Rq5Yh8rTXxg" name="MassTransferMucosaToPveBC" description="Mass transfer from Mucosa:Blood Cells To Portal Vein: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="oPq1gXd_K0-5kvXMk9dAuw" sourceAmount="KO0_pqb3mkWfWurFI6aujA" targetAmount="RCAqJaBNgE-vkuaKfPZpnw" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="eoCJ7gH10kyTBMrVp-UWHw" name="PortalVein_pls_PortalVein_bc" description="Neighborhood between PortalVein/Plasma and PortalVein/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="s_QiQGLN10Omt7YLmTFwjg" secondNeighbor="-iUsllv1MkOvPkSoihwHiA">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / BloodCells" />
+                </Tags>
+                <Children>
+                  <Container id="QimmQ4MXhEm-1qxh-hUV7A" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="Y2zsgwNx60Gwtt8CSEbWBw" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="U3bGkEvcz065prA3j0g43g" sourceAmount="JvJXBdwv-UOGE6DoopBJuA" targetAmount="RCAqJaBNgE-vkuaKfPZpnw" />
+                    </Children>
+                  </Container>
+                  <Parameter id="PcPkD2j6C0SVzMuI99CnOg" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="0wNsC_CVjUOEITfk7jqrEA" isDefault="1" displayUnit="cm²">
+                    <Tags>
+                      <Tag value="Neighborhood: Plasma / BloodCells" />
+                    </Tags>
+                    <Info min="0" flag="122" seq="16" ref="0" bb="32" group="104" />
+                  </Parameter>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="R9jJN3VYL0um1XC-3oXqzA" name="Skin_bc_VenousBlood_bc" description="Neighborhood between Skin/Blood Cells and Venous Blood/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="-ecrPvvqpkyCCZH2q8_isQ" secondNeighbor="9pDSL8Nq0US2M-Z4-4NiNw">
+                <Tags>
+                  <Tag value="Neighborhood: BloodCells / BloodCells" />
+                </Tags>
+                <Children>
+                  <Container id="i-2QnANhsE-vwoB_dYOSjw" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="OQQaBzLHjkiZazCE6M1FPA" name="MassTransferOrgRBC2BloodPool" description="Mass transfer from organ: Blood Cells to Arterial Blood: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="8N-5YA2mOkuNznVV6JfEyw" sourceAmount="oEugrKOiFU6poyyXxk4M5w" targetAmount="C5df-rtR9kqsgkV4ZWZUKg" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="fdAg6-aTIUOC95YHhprkRA" name="Skin_int_Skin_cell" description="Neighborhood between Skin/Interstitial and Skin/Intracellular" mode="Logical" containerType="Neighborhood" firstNeighbor="0VwJ4a3WTUaKXCvSR4Y19A" secondNeighbor="NumIY7PtTkaOZIXNtZD3Nw">
+                <Tags>
+                  <Tag value="Neighborhood: Interstitial / Intracellular" />
+                </Tags>
+                <Children>
+                  <Container id="vtECbDFtsEawjYe68McNxg" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="59prxQhL90qFD_BMRX6xTw" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="iF9O5xA_e0SIVFmFG1ht8A" isDefault="1" displayUnit="cm/min">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="78" />
+                      </Parameter>
+                      <Parameter id="yv5GgUiPG0SsUsENpwTkOQ" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="IKrcjT7b50S-hZpXm7B5cQ" isDefault="1" displayUnit="cm/min">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="76" />
+                      </Parameter>
+                      <Parameter id="-jX-xqE4nkuFit8jduMyWw" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="M2WXUlVpY0W18PhhdNB88Q" isDefault="1" displayUnit="l/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="F_L16g4_u0eOko5vH7Y6hA" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="70Te4TWLFEi68KKWZ6BTqA" isDefault="1" displayUnit="l/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="cw-9ex7ym0GXxcgaBsK1NA" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="P9FQ9FkvXkCaLjkKQk2eRQ" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="vv1x1dw21UqSlE8JglNEbg" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BdF9P4wGWEi2kQOvOit64g" isDefault="1">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="69" />
+                      </Parameter>
+                      <Parameter id="RXG1wyPpCUaGAmA4hsLBPg" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cf5OHy-pE0-BjjqyfS_nTg" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+                      </Parameter>
+                      <Parameter id="QvM0wMd56kqnLdNFPEzsbg" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="_FPQ0MxdY0Oll_gwH-TEIQ" isDefault="1">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Transport id="J4x-_3GBi0iUlWeaBCJsbw" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Transport" dimension="Amount per time" formula="ZIgnr4j8RU6hncyh8wSylA" sourceAmount="na09UxfmdkCKb3z4r0fjmA" targetAmount="b1xAoQb40kqPK9ffH5EYRA" />
+                    </Children>
+                  </Container>
+                  <Parameter id="CngR9ir8pka9WxIMAKMywA" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="KQ54ZdqkcUuuRdu2Es8YNQ" isDefault="1" displayUnit="cm²">
+                    <Tags>
+                      <Tag value="Neighborhood: Interstitial / Intracellular" />
+                    </Tags>
+                    <Info min="0" flag="122" seq="14" ref="0" bb="32" group="105" />
+                  </Parameter>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="Hj86CMISA0CutTiDwm58Ng" name="Skin_pls_Skin_bc" description="Neighborhood between Skin/Plasma and Skin/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="eTnjoGpclkKg5pWP1EfS6g" secondNeighbor="-ecrPvvqpkyCCZH2q8_isQ">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / BloodCells" />
+                </Tags>
+                <Children>
+                  <Container id="azgXKaTB2ki-4ZJhRTag0g" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="qsuTNjvXHEysjsUx1FFePQ" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="IHNbEto4902hVIxemxAJCQ" sourceAmount="-L3poskufEiY_yLCZj9nlg" targetAmount="oEugrKOiFU6poyyXxk4M5w" />
+                    </Children>
+                  </Container>
+                  <Parameter id="xFD62Z0JPUezeSS2x7Lgtw" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="yHkNUphU_U2XUrr5N6hOYw" isDefault="1" displayUnit="cm²">
+                    <Tags>
+                      <Tag value="Neighborhood: Plasma / BloodCells" />
+                    </Tags>
+                    <Info min="0" flag="122" seq="17" ref="0" bb="32" group="104" />
+                  </Parameter>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="kQ7_ymO6BEmmig-t4bMSVQ" name="Skin_pls_Skin_int" description="Neighborhood between Skin/Plasma and Skin/Interstitial" mode="Logical" containerType="Neighborhood" firstNeighbor="eTnjoGpclkKg5pWP1EfS6g" secondNeighbor="0VwJ4a3WTUaKXCvSR4Y19A">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / Interstitial" />
+                </Tags>
+                <Children>
+                  <Container id="GXaJaOLRzE6n0QDPawQsCA" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="-RoHMez8OEmmNerpXhxUhw" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
+                        <ValueOrigin id="49" source="Other" method="Assumption" description="Assumption: very fast exchange" />
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="77" />
+                      </Parameter>
+                      <Parameter id="owIABV-uCk2JTWFT0NvZWA" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="WO-8Vog5vUuNvOpjrIOoOg" isDefault="1">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="70" />
+                      </Parameter>
+                      <Transport id="aIlrjMpcMEmAgJo7B1OPGg" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Transport" dimension="Amount per time" formula="l7VM0jGFMUaPcvWFsfa6vg" sourceAmount="-L3poskufEiY_yLCZj9nlg" targetAmount="na09UxfmdkCKb3z4r0fjmA" />
+                    </Children>
+                  </Container>
+                  <Parameter id="ypa9t_N3aUulhNSa_WQ9RA" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="PhrkxFVtCEiPXoqqZ_VQgQ" isDefault="1" displayUnit="cm²">
+                    <Tags>
+                      <Tag value="Neighborhood: Plasma / Interstitial" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="14" ref="0" bb="32" group="106" />
+                  </Parameter>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="cWQiALkASkqsBdRyAgNSrQ" name="Skin_pls_VenousBlood_pls" description="Neighborhood between Skin/Plasma and Venous Blood/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="eTnjoGpclkKg5pWP1EfS6g" secondNeighbor="7Skx_VpY1kGT74Rns_5puw">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / Plasma" />
+                </Tags>
+                <Children>
+                  <Container id="shzgjCvjIEetngkcXcsUeQ" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="FwCK7yxG30GzP6qFsl1DWQ" name="MassTransferOrgPl2BloodPool" description="Mass transfer from organ: Plasma to Venous Blood: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="BjcuzRf7yEyR13KPDSeXmw" sourceAmount="-L3poskufEiY_yLCZj9nlg" targetAmount="7Rbeovs3_k-ueQGXqYkAXw" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="y2MbY0njx0CqC-egh2daMg" name="Spleen_bc_PortalVein_bc" description="Neighborhood between Spleen/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="A67vaaAIQk6PwZbW1swmtA" secondNeighbor="-iUsllv1MkOvPkSoihwHiA">
+                <Tags>
+                  <Tag value="Neighborhood: BloodCells / BloodCells" />
+                </Tags>
+                <Children>
+                  <Container id="EXWmtYj5G0GRizN8kptWDQ" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="heFcS8s-_Ee9SCnmWCGnuQ" name="MassTransferOrgRBC2BloodPool_Pve" description="Mass transfer from organ: Blood Cells to Portal Vein: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="eO-2dYZot021eRuziikelw" sourceAmount="t1oyMNylSECwz5JjP5KtSA" targetAmount="RCAqJaBNgE-vkuaKfPZpnw" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="n2RoHxTUtU2EQFYE-cGUeA" name="Spleen_int_Spleen_cell" description="Neighborhood between Spleen/Interstitial and Spleen/Intracellular" mode="Logical" containerType="Neighborhood" firstNeighbor="MO2TpXEcK0KOZEsv5Nq2OA" secondNeighbor="YRJumXM5KUqzWqmGgvcsXQ">
+                <Tags>
+                  <Tag value="Neighborhood: Interstitial / Intracellular" />
+                </Tags>
+                <Children>
+                  <Container id="07oCg_AmJkyQkFyo9tvu4g" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="5GDb7nGMFk-Yyn924IiREA" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="iF9O5xA_e0SIVFmFG1ht8A" isDefault="1" displayUnit="cm/min">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="78" />
+                      </Parameter>
+                      <Parameter id="QIdTT7Gf90ibriI1QEjRVw" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="IKrcjT7b50S-hZpXm7B5cQ" isDefault="1" displayUnit="cm/min">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="76" />
+                      </Parameter>
+                      <Parameter id="VnM68bKxkUicbml-nJf88g" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="M2WXUlVpY0W18PhhdNB88Q" isDefault="1" displayUnit="l/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="w7-mIToz8Em1xydHzha76g" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="70Te4TWLFEi68KKWZ6BTqA" isDefault="1" displayUnit="l/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="jaMxfpuwYEOJ69BI73nPog" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="XnAIPpsFWU-OXCW4Jodr6w" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="hZpWMym09EaM-dI5dKH1Pw" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="0TZF9Yg-EEGnTnojTJFViQ" isDefault="1">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="69" />
+                      </Parameter>
+                      <Parameter id="z965v4QKFkymJluy7GFDqw" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cf5OHy-pE0-BjjqyfS_nTg" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+                      </Parameter>
+                      <Parameter id="MvcrjlSApU2UGW9k0_OeDw" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="YwNsPggXOkCQzuPpCs1zWQ" isDefault="1">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Transport id="rqQFsf7yBkqy_MEya6_sYA" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Transport" dimension="Amount per time" formula="ybnV79My-0yNs0CF-rffIQ" sourceAmount="ipIddIhwKkuR3ya3uFhpuA" targetAmount="X2mXPf7OTk2HfsrCSwuU9w" />
+                    </Children>
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+                  <Parameter id="on__NK1_wkmaMwixASappQ" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="0qeIaMN2H0O01WqH7jT_PA" isDefault="1" displayUnit="cm²">
+                    <Tags>
+                      <Tag value="Neighborhood: Interstitial / Intracellular" />
+                    </Tags>
+                    <Info min="0" flag="122" seq="16" ref="0" bb="32" group="105" />
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+              </Neighborhood>
+              <Neighborhood id="c-IhjjZ53EyKJa93dzoM3w" name="Spleen_pls_PortalVein_pls" description="Neighborhood between Spleen/Plasma and PortalVein/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="DtIYfXogNkW8hZs4wYJNHQ" secondNeighbor="s_QiQGLN10Omt7YLmTFwjg">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / Plasma" />
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+                <Children>
+                  <Container id="-Gzg28X440WPr4gD3z73jQ" name="Aciclovir" mode="Logical" containerType="Molecule">
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+                <Tags>
+                  <Tag value="Neighborhood: Plasma / BloodCells" />
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+                <Children>
+                  <Container id="jwVYP_MQW0SlCGvQ4IZF2Q" name="Aciclovir" mode="Logical" containerType="Molecule">
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+                    </Children>
+                  </Container>
+                  <Parameter id="lyLVA0STWEGd9N7LbjdyHw" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="o1PpBbkNTEGzCSuSbZFv-Q" isDefault="1" displayUnit="cm²">
+                    <Tags>
+                      <Tag value="Neighborhood: Plasma / BloodCells" />
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+                    <Info min="0" flag="122" seq="19" ref="0" bb="32" group="104" />
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+              <Neighborhood id="Xr8EoHnAgU-q4wzCRD6Pxw" name="Spleen_pls_Spleen_int" description="Neighborhood between Spleen/Plasma and Spleen/Interstitial" mode="Logical" containerType="Neighborhood" firstNeighbor="DtIYfXogNkW8hZs4wYJNHQ" secondNeighbor="MO2TpXEcK0KOZEsv5Nq2OA">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / Interstitial" />
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+                <Children>
+                  <Container id="Lm75cLiNyU6doG2aRn869A" name="Aciclovir" mode="Logical" containerType="Molecule">
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+                        <ValueOrigin id="49" source="Other" method="Assumption" description="Assumption: very fast exchange" />
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="77" />
+                      </Parameter>
+                      <Parameter id="yhWvkTS_cEes075Kj6DCbg" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="WO-8Vog5vUuNvOpjrIOoOg" isDefault="1">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="70" />
+                      </Parameter>
+                      <Transport id="9F_0gjmvqE2O5wQ73bzBNw" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Transport" dimension="Amount per time" formula="lSW-SdsSCkKHW_BYHk8CYg" sourceAmount="Gtf9_5p6HUOjDhTB24z5BA" targetAmount="ipIddIhwKkuR3ya3uFhpuA" />
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+                  </Container>
+                  <Parameter id="ubTFVqW7ckW7T4fRcW8VzQ" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="LXpV874LcE-86eixaqIRlg" isDefault="1" displayUnit="cm²">
+                    <Tags>
+                      <Tag value="Neighborhood: Plasma / Interstitial" />
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+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="16" ref="0" bb="32" group="106" />
+                  </Parameter>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="62Oczfoam0eN7EIiFOqv1A" name="Saliva_slv_Saliva_slv" description="Neighborhood between Saliva/SalivaGland and Saliva/Saliva" mode="Logical" containerType="Neighborhood" firstNeighbor="GlF1QttcxkaOGCn6RfmDJQ" secondNeighbor="h3pp6FWR10unTBCHqvqmjA">
+                <Tags>
+                  <Tag value="Neighborhood: SalivaGland / Saliva" />
+                </Tags>
+                <Children>
+                  <Container id="efXVk7oae06WB3I7Kc5bFw" name="Aciclovir" mode="Logical" containerType="Molecule">
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+                      <Parameter id="9R4YEkPJ_kSYYHmaGzocCg" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="-PfrO3dFOEGYGele2UUqfw" isDefault="1">
+                        <ValueOrigin id="43" source="Internet" description="Willi Cawello. Pharmacokinetics and bioavailability derived from various body fluids. http://www.agah.eu/fileadmin/_migrated/content_uploads/W._Cawello__2__25.05.07.pdf" />
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="69" />
+                      </Parameter>
+                      <Parameter id="IXMgrKRP6k-ffv_ULvaIdg" name="SalivaPlasmaRatio" description="Ratio of saliva vs. plasma concentrations" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="UsUIkG8VRUKISl4fnBkSiA" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="22" />
+                      </Parameter>
+                      <Transport id="GaMcBT9iGkGSgOLeFT5yNA" name="PassiveDiffusionPlsToSaliva" description="Passive diffusion plasma to saliva" mode="Logical" containerType="Transport" dimension="Amount per time" formula="bj8TlB9sbkOftQq56URKRw" sourceAmount="LdXi4b5WN0C6yAu6YjkLwA" targetAmount="hVY-Xq-o50yIypC45J_wSA" />
+                    </Children>
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+              <Neighborhood id="_cor1fFf70uJXLOuYtHq3g" name="Duodenum_int_Duodenum_cell" description="Neighborhood between Small Intestine/Mucosa/Duodenum/Interstitial and Small Intestine/Mucosa/Duodenum/Intracellular" mode="Logical" containerType="Neighborhood" firstNeighbor="Vo76JuhYy02oPyD6ImT7LQ" secondNeighbor="Aj167RPpD0WYC-nZy2suGA">
+                <Tags>
+                  <Tag value="Neighborhood: Interstitial / Intracellular" />
+                  <Tag value="Small intestine  neighborhood" />
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+                <Children>
+                  <Container id="GSvMCY0sMEGdP9QPZD7cuw" name="Aciclovir" mode="Logical" containerType="Molecule">
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+                      <Parameter id="040690PyqUmmEH8e9lZsTw" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="CDnoPurpsUuJ5R948GReCw" isDefault="1" displayUnit="cm/min">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="135" />
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+                      <Parameter id="faP9icsXWES71nyDtoLuoA" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="iYnVDTptR0OXWIAspZi4IA" isDefault="1" displayUnit="cm/min">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="133" />
+                      </Parameter>
+                      <Parameter id="RwQOSiSZZ0CpcxXDGxXMIw" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="M2WXUlVpY0W18PhhdNB88Q" isDefault="1" displayUnit="l/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="prFkBZiu_UaF_xjRECy9eQ" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="70Te4TWLFEi68KKWZ6BTqA" isDefault="1" displayUnit="l/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="ptLAek5I1UKM6sv42lgEsg" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="CopD6LItrESvS_J5tz8mMg" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="znisy9xb_kGnnNVW3-IApw" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="X6PCQs-JbkGbHPGzsfhvRw" isDefault="1">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="147" />
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+                      <Parameter id="darOmcg7OESPdnTM5YxUaQ" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cf5OHy-pE0-BjjqyfS_nTg" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+                      </Parameter>
+                      <Parameter id="gnmh__UhZEKoj_gcj_M0Lw" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="4BlVBMvtg0Gz7B9zQVORSw" isDefault="1">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Transport id="5s9qSTD7u0qgT7Rcp5H9VA" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Transport" dimension="Amount per time" formula="otKCzP04Ukq89Fphf-bO3A" sourceAmount="Hv29XC4xqka5x3gWLx65cw" targetAmount="WZvp19tK5EuOI6FlH_xZ0g" />
+                    </Children>
+                  </Container>
+                  <Parameter id="3OhwBQI7hUecEr6IE50gWw" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="GnAU-oowO0CvXxIdiRaZuQ" isDefault="1" displayUnit="cm²">
+                    <Tags>
+                      <Tag value="Neighborhood: Interstitial / Intracellular" />
+                      <Tag value="Small intestine  neighborhood" />
+                    </Tags>
+                    <Info min="0" flag="122" seq="18" ref="0" bb="32" group="105" />
+                  </Parameter>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="9lTMlMKoYEK_RurhEgiANQ" name="Duodenum_pls_Duodenum_bc" description="Neighborhood between Small Intestine/Mucosa/Duodenum/Plasma and Small Intestine/Mucosa/Duodenum/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="XAgCyFXUeEiKySGRkrx1lw" secondNeighbor="YoUcbCdrsUy6MzLzw16fQA">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / BloodCells" />
+                  <Tag value="Small intestine  neighborhood" />
+                </Tags>
+                <Children>
+                  <Container id="_D6DATWJF0OmAcgiaueNQA" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="hiULbvLkDUy5eCrCRmxJsw" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="UCOeV89L3UaQp9lUBzOaSQ" sourceAmount="6jMviBffOESTP5M0G7YuJg" targetAmount="NSDFFYYE00y77UxrZNLCtQ" />
+                    </Children>
+                  </Container>
+                  <Parameter id="r0FtyHh35UaCV16mdoKojQ" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="mxrKwtc7FEO4GCUdDAHPjw" isDefault="1" displayUnit="cm²">
+                    <Tags>
+                      <Tag value="Neighborhood: Plasma / BloodCells" />
+                      <Tag value="Small intestine  neighborhood" />
+                    </Tags>
+                    <Info min="0" flag="122" seq="21" ref="0" bb="32" group="104" />
+                  </Parameter>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="HifS2kzeHUCKs6Tud5_KEQ" name="Duodenum_pls_Duodenum_int" description="Neighborhood between Small Intestine/Mucosa/Duodenum/Plasma and Small Intestine/Mucosa/Duodenum/Interstitial" mode="Logical" containerType="Neighborhood" firstNeighbor="XAgCyFXUeEiKySGRkrx1lw" secondNeighbor="Vo76JuhYy02oPyD6ImT7LQ">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / Interstitial" />
+                  <Tag value="Small intestine  neighborhood" />
+                </Tags>
+                <Children>
+                  <Container id="fKOKGBpkyUa4tKW7SLaDmw" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="GUmFKT7Cgku1RbD2LdyCvA" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
+                        <ValueOrigin id="49" source="Other" method="Assumption" description="Assumption: very fast exchange" />
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="134" />
+                      </Parameter>
+                      <Parameter id="NhI1BwI8Iky_C-Ys8sIV6A" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="WO-8Vog5vUuNvOpjrIOoOg" isDefault="1">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="148" />
+                      </Parameter>
+                      <Transport id="SD5cyMNF8EKWI4y-4SWd3g" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Transport" dimension="Amount per time" formula="8yYnLhvFaUCkCFKxhM2zZw" sourceAmount="6jMviBffOESTP5M0G7YuJg" targetAmount="Hv29XC4xqka5x3gWLx65cw" />
+                    </Children>
+                  </Container>
+                  <Parameter id="479R49-FCk2wq_Ck19SyXg" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="Oi-k9bSjkkaLHkNh0PVFVQ" isDefault="1" displayUnit="cm²">
+                    <Tags>
+                      <Tag value="Neighborhood: Plasma / Interstitial" />
+                      <Tag value="Small intestine  neighborhood" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="18" ref="0" bb="32" group="106" />
+                  </Parameter>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="V9LC5AzDL0WXzXxJ9sbrGg" name="UpperJejunum_int_UpperJejunum_cell" description="Neighborhood between Small Intestine/Mucosa/Upper Jejunum/Interstitial and Small Intestine/Mucosa/Upper Jejunum/Intracellular" mode="Logical" containerType="Neighborhood" firstNeighbor="9BNnxREkqkyzR0WtWnKqAw" secondNeighbor="TQzcOQRzpECL6ftYDxUa4A">
+                <Tags>
+                  <Tag value="Neighborhood: Interstitial / Intracellular" />
+                  <Tag value="Small intestine  neighborhood" />
+                </Tags>
+                <Children>
+                  <Container id="-_S7yEm4qE2B-SBanpFrBw" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="ShdBmcHmr0mrGVxo2it6lQ" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="CDnoPurpsUuJ5R948GReCw" isDefault="1" displayUnit="cm/min">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="135" />
+                      </Parameter>
+                      <Parameter id="XZSTeMp7m0yh3UzsEKY4jg" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="iYnVDTptR0OXWIAspZi4IA" isDefault="1" displayUnit="cm/min">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="133" />
+                      </Parameter>
+                      <Parameter id="3wCXoBqIrkeXQdMeNIsYeg" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="M2WXUlVpY0W18PhhdNB88Q" isDefault="1" displayUnit="l/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="6hQegqgVD0yWMdNHux11gA" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="70Te4TWLFEi68KKWZ6BTqA" isDefault="1" displayUnit="l/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="hBayCt-fWEixdNqfkAHgOg" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="Jn-ZlCKTUkaydmR9cv0KVg" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="ceVewTjzqkO84mu90kZpqg" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="hd5BZATPAE-bWKo_dJaexw" isDefault="1">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="147" />
+                      </Parameter>
+                      <Parameter id="cu2lG8l7o0aVNwgt5FZAvw" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cf5OHy-pE0-BjjqyfS_nTg" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+                      </Parameter>
+                      <Parameter id="5ka28FQxcEGeenDShRMxhA" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="4BlVBMvtg0Gz7B9zQVORSw" isDefault="1">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Transport id="-MwAokOsBUufYynRwbIu8A" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Transport" dimension="Amount per time" formula="KiqiyFI0cUGYqPlf10hLSw" sourceAmount="kFq7YlSwm0eQTq3NnvSNvQ" targetAmount="1JhFILMnCkmu_eod-U80pA" />
+                    </Children>
+                  </Container>
+                  <Parameter id="Ay4rDJANdk6-MGGUpp7PVA" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="LuNixFBXpkmyN9LGUjam2Q" isDefault="1" displayUnit="cm²">
+                    <Tags>
+                      <Tag value="Neighborhood: Interstitial / Intracellular" />
+                      <Tag value="Small intestine  neighborhood" />
+                    </Tags>
+                    <Info min="0" flag="122" seq="19" ref="0" bb="32" group="105" />
+                  </Parameter>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="OYShGOxI9E2SSMS5aJsIWw" name="UpperJejunum_pls_UpperJejunum_bc" description="Neighborhood between Small Intestine/Mucosa/Upper Jejunum/Plasma and Small Intestine/Mucosa/Upper Jejunum/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="AdnIgrbZwUCQM9gcoqPNFg" secondNeighbor="Gu_kquVcG0O_zuSeiO8r4Q">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / BloodCells" />
+                  <Tag value="Small intestine  neighborhood" />
+                </Tags>
+                <Children>
+                  <Container id="KoPweiTIOUmQ3ockCC_rXg" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="My7_-VpIYEC0_j4GfpdNIg" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="ps5Zk_aHUUCem8e1AVYMWg" sourceAmount="jXed7RBVDE-arIEOj4e22g" targetAmount="_8TJYo65bE2WdF0w6RPdjQ" />
+                    </Children>
+                  </Container>
+                  <Parameter id="29df-MStAEGqsoJ02z66Qw" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="0kwjuH7hqkqwQZLXQ9W_qA" isDefault="1" displayUnit="cm²">
+                    <Tags>
+                      <Tag value="Neighborhood: Plasma / BloodCells" />
+                      <Tag value="Small intestine  neighborhood" />
+                    </Tags>
+                    <Info min="0" flag="122" seq="22" ref="0" bb="32" group="104" />
+                  </Parameter>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="W39XcVGDBUibGbWmKrymIg" name="UpperJejunum_pls_UpperJejunum_int" description="Neighborhood between Small Intestine/Mucosa/Upper Jejunum/Plasma and Small Intestine/Mucosa/Upper Jejunum/Interstitial" mode="Logical" containerType="Neighborhood" firstNeighbor="AdnIgrbZwUCQM9gcoqPNFg" secondNeighbor="9BNnxREkqkyzR0WtWnKqAw">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / Interstitial" />
+                  <Tag value="Small intestine  neighborhood" />
+                </Tags>
+                <Children>
+                  <Container id="Lt6UsdDy6Em6EUUzNGGoTg" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="1JlF7zrEiEePlEGxKg0zDg" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
+                        <ValueOrigin id="49" source="Other" method="Assumption" description="Assumption: very fast exchange" />
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="134" />
+                      </Parameter>
+                      <Parameter id="kTgu9ymL2UGsYMQTUE-RTw" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="WO-8Vog5vUuNvOpjrIOoOg" isDefault="1">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="148" />
+                      </Parameter>
+                      <Transport id="6lnOiIddg0yKPbsqvUvcjw" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Transport" dimension="Amount per time" formula="SJee0tR3mUK79WAAWsKW1A" sourceAmount="jXed7RBVDE-arIEOj4e22g" targetAmount="kFq7YlSwm0eQTq3NnvSNvQ" />
+                    </Children>
+                  </Container>
+                  <Parameter id="Td48hzbTf0iQDjTULqVaGw" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="SVAHOPoXPkCcUvM1VjXJLQ" isDefault="1" displayUnit="cm²">
+                    <Tags>
+                      <Tag value="Neighborhood: Plasma / Interstitial" />
+                      <Tag value="Small intestine  neighborhood" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="19" ref="0" bb="32" group="106" />
+                  </Parameter>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="k8kVQIafAkSJlXIW3G-zZA" name="LowerJejunum_int_LowerJejunum_cell" description="Neighborhood between Small Intestine/Mucosa/Lower Jejunum/Interstitial and Small Intestine/Mucosa/Lower Jejunum/Intracellular" mode="Logical" containerType="Neighborhood" firstNeighbor="GzTlzCxSCkKQdR_RVBxrwg" secondNeighbor="LMUmav6ZqUmNU0OFAGoySg">
+                <Tags>
+                  <Tag value="Neighborhood: Interstitial / Intracellular" />
+                  <Tag value="Small intestine  neighborhood" />
+                </Tags>
+                <Children>
+                  <Container id="mw7gamKCuky6zlqMRp-drA" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="x_IqE0ZVq0-I--X_ubmUfQ" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="CDnoPurpsUuJ5R948GReCw" isDefault="1" displayUnit="cm/min">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="135" />
+                      </Parameter>
+                      <Parameter id="vnqwBNWy8ECFSqj-yUEaHw" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="iYnVDTptR0OXWIAspZi4IA" isDefault="1" displayUnit="cm/min">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="133" />
+                      </Parameter>
+                      <Parameter id="0WRsyOkV9UGTwtv3XoG-6g" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="M2WXUlVpY0W18PhhdNB88Q" isDefault="1" displayUnit="l/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="EIHMt3v6U0izsCUWbzWO9g" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="70Te4TWLFEi68KKWZ6BTqA" isDefault="1" displayUnit="l/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="PbyTQahi_0GawkTJaxMc7w" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="nRQSut5Cm0ehIVLnmHVBaQ" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="En2F9LSeWEWi42vAChVX5w" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="AFhH8laTqke9SIJ9U-uh7w" isDefault="1">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="147" />
+                      </Parameter>
+                      <Parameter id="BSC7OUCPj0aEnNeR4FjDKQ" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cf5OHy-pE0-BjjqyfS_nTg" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+                      </Parameter>
+                      <Parameter id="1G8xXwtcmUej0Aizaxswzg" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="4BlVBMvtg0Gz7B9zQVORSw" isDefault="1">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Transport id="ScrpjVNVR0OXn46by8hF9w" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Transport" dimension="Amount per time" formula="rHU-n61clk63p0dAjiAUfQ" sourceAmount="PV1R_ZhQTk6MVXwAKpn-Iw" targetAmount="X63NpTl_LEiYK284w5QvOQ" />
+                    </Children>
+                  </Container>
+                  <Parameter id="54YLDvQDcEaF6dFZlNoVdg" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="tZbXpC46PUSgyQ7yoZ_iDw" isDefault="1" displayUnit="cm²">
+                    <Tags>
+                      <Tag value="Neighborhood: Interstitial / Intracellular" />
+                      <Tag value="Small intestine  neighborhood" />
+                    </Tags>
+                    <Info min="0" flag="122" seq="20" ref="0" bb="32" group="105" />
+                  </Parameter>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="dtLiNJ4WkEy9fcfvmriLuQ" name="LowerJejunum_pls_LowerJejunum_bc" description="Neighborhood between Small Intestine/Mucosa/Lower Jejunum/Plasma and Small Intestine/Mucosa/Lower Jejunum/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="UFlatkQIoEK5k-bXY6FG-Q" secondNeighbor="yDYh6-IkUEWuusihzT3Z-g">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / BloodCells" />
+                  <Tag value="Small intestine  neighborhood" />
+                </Tags>
+                <Children>
+                  <Container id="1EIW5OK0Mk6xs-IZ_4REJQ" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="iMUte74dWU-pe0kYgtIBMg" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="YR2gQDJilkaYbybBnc8Hpw" sourceAmount="MFQ1DjGCz0GYLNDQI5iUVg" targetAmount="1QLHcUXHTEqOYm9JCRavcw" />
+                    </Children>
+                  </Container>
+                  <Parameter id="-FgZSIc80Ees6Q4KPiAb9g" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="WwVEkQqJJUGyreyj3jqvVg" isDefault="1" displayUnit="cm²">
+                    <Tags>
+                      <Tag value="Neighborhood: Plasma / BloodCells" />
+                      <Tag value="Small intestine  neighborhood" />
+                    </Tags>
+                    <Info min="0" flag="122" seq="23" ref="0" bb="32" group="104" />
+                  </Parameter>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="w_G0KnvBTEeAyKP_dMCEZQ" name="LowerJejunum_pls_LowerJejunum_int" description="Neighborhood between Small Intestine/Mucosa/Lower Jejunum/Plasma and Small Intestine/Mucosa/Lower Jejunum/Interstitial" mode="Logical" containerType="Neighborhood" firstNeighbor="UFlatkQIoEK5k-bXY6FG-Q" secondNeighbor="GzTlzCxSCkKQdR_RVBxrwg">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / Interstitial" />
+                  <Tag value="Small intestine  neighborhood" />
+                </Tags>
+                <Children>
+                  <Container id="utSbVrF5SkurK0ev0b9ktw" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="JkK0MrSPeEOoiza1KRzMmQ" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
+                        <ValueOrigin id="49" source="Other" method="Assumption" description="Assumption: very fast exchange" />
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="134" />
+                      </Parameter>
+                      <Parameter id="nvO2HDsrkEOdR79NlTD5UQ" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="WO-8Vog5vUuNvOpjrIOoOg" isDefault="1">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="148" />
+                      </Parameter>
+                      <Transport id="CotOs5-yr0SiCFO767DIJQ" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Transport" dimension="Amount per time" formula="BEx-V08WkESn7J6yQFENMA" sourceAmount="MFQ1DjGCz0GYLNDQI5iUVg" targetAmount="PV1R_ZhQTk6MVXwAKpn-Iw" />
+                    </Children>
+                  </Container>
+                  <Parameter id="ezhC7Qsup0uPbdVQDDm7ow" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="foccmafK5keY-pmZ115byA" isDefault="1" displayUnit="cm²">
+                    <Tags>
+                      <Tag value="Neighborhood: Plasma / Interstitial" />
+                      <Tag value="Small intestine  neighborhood" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="20" ref="0" bb="32" group="106" />
+                  </Parameter>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="1C4K1JdTOEKEurpHyBojcA" name="UpperIleum_int_UpperIleum_cell" description="Neighborhood between Small Intestine/Mucosa/Upper Ileum/Interstitial and Small Intestine/Mucosa/Upper Ileum/Intracellular" mode="Logical" containerType="Neighborhood" firstNeighbor="ndUKDPX3lEy2sG1SyfoKVw" secondNeighbor="Ff3WHy-9B0m4L3fVbldxJw">
+                <Tags>
+                  <Tag value="Neighborhood: Interstitial / Intracellular" />
+                  <Tag value="Small intestine  neighborhood" />
+                </Tags>
+                <Children>
+                  <Container id="gnGKrPKyJUm0fcAD_0Ll0A" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="ZNu-9DCHDUi2WfNh4lT4yg" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="CDnoPurpsUuJ5R948GReCw" isDefault="1" displayUnit="cm/min">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="135" />
+                      </Parameter>
+                      <Parameter id="pz5eiNONokKSUVog8QhSMQ" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="iYnVDTptR0OXWIAspZi4IA" isDefault="1" displayUnit="cm/min">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="133" />
+                      </Parameter>
+                      <Parameter id="Ke4uCNOJz06LsjUrNynHJQ" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="M2WXUlVpY0W18PhhdNB88Q" isDefault="1" displayUnit="l/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="ebQOcUifqEOC9vSGWvE8NA" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="70Te4TWLFEi68KKWZ6BTqA" isDefault="1" displayUnit="l/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="aq8oc2yjKEieOuJCGwGdug" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="Qn4VN_DH_kupJF76JnYEzg" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="sGZX76F8QE2TszfaRvsurQ" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="SgyJE8kss06RlETywf9ifA" isDefault="1">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="147" />
+                      </Parameter>
+                      <Parameter id="rTrQHBC8_kuOiObJ2INxdA" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cf5OHy-pE0-BjjqyfS_nTg" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+                      </Parameter>
+                      <Parameter id="v4D7Y0FYWkicVJbrV_fYwg" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="4BlVBMvtg0Gz7B9zQVORSw" isDefault="1">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Transport id="rDFQltFu9ES8QFNu7NzUbA" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Transport" dimension="Amount per time" formula="pk4qdq8J8UGaJcPgpCp3MQ" sourceAmount="tu8hTALhIU261xTE_bVAsA" targetAmount="464kpYtSoEmHbsxIEfBICQ" />
+                    </Children>
+                  </Container>
+                  <Parameter id="HOlOFT6NQEGiqLHpNGFtFA" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="PLhFR48Sb0KphuuBlVDG5w" isDefault="1" displayUnit="cm²">
+                    <Tags>
+                      <Tag value="Neighborhood: Interstitial / Intracellular" />
+                      <Tag value="Small intestine  neighborhood" />
+                    </Tags>
+                    <Info min="0" flag="122" seq="21" ref="0" bb="32" group="105" />
+                  </Parameter>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="yqGXJn_dq0SlkKzc9J8qQQ" name="UpperIleum_pls_UpperIleum_bc" description="Neighborhood between Small Intestine/Mucosa/Upper Ileum/Plasma and Small Intestine/Mucosa/Upper Ileum/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="Y_s9pV1ZD0Ww0f15vGUCCQ" secondNeighbor="LlnYb8D-S0u4Z42FsmcSiA">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / BloodCells" />
+                  <Tag value="Small intestine  neighborhood" />
+                </Tags>
+                <Children>
+                  <Container id="ATUeIJygH0WwtvugcT_qAg" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="iiAjrIstY0erDuopMx5m1A" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="741eB6ICaU6X6EuUh1Ym_w" sourceAmount="5v1KSGAk70O10rniubnfVw" targetAmount="do9IUbs9QUm3akwTT0LqpQ" />
+                    </Children>
+                  </Container>
+                  <Parameter id="EbkuBESklkSr0YSprv3tEQ" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="xOWvQpfAHUquQhCaB1S38g" isDefault="1" displayUnit="cm²">
+                    <Tags>
+                      <Tag value="Neighborhood: Plasma / BloodCells" />
+                      <Tag value="Small intestine  neighborhood" />
+                    </Tags>
+                    <Info min="0" flag="122" seq="24" ref="0" bb="32" group="104" />
+                  </Parameter>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="4ojPglX0NEerKlWYXCvpCQ" name="UpperIleum_pls_UpperIleum_int" description="Neighborhood between Small Intestine/Mucosa/Upper Ileum/Plasma and Small Intestine/Mucosa/Upper Ileum/Interstitial" mode="Logical" containerType="Neighborhood" firstNeighbor="Y_s9pV1ZD0Ww0f15vGUCCQ" secondNeighbor="ndUKDPX3lEy2sG1SyfoKVw">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / Interstitial" />
+                  <Tag value="Small intestine  neighborhood" />
+                </Tags>
+                <Children>
+                  <Container id="-0G_4v0AvEmTtKMkJGLqsQ" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="lryt0oykikiGa1DvnpJvSw" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
+                        <ValueOrigin id="49" source="Other" method="Assumption" description="Assumption: very fast exchange" />
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="134" />
+                      </Parameter>
+                      <Parameter id="0ItzCxtCZkCi6iKz9r56Tw" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="WO-8Vog5vUuNvOpjrIOoOg" isDefault="1">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="148" />
+                      </Parameter>
+                      <Transport id="HnUXfmZDrU6Vy4TWBXtG9g" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Transport" dimension="Amount per time" formula="BwlkDXtfME2PjaxuwSphPQ" sourceAmount="5v1KSGAk70O10rniubnfVw" targetAmount="tu8hTALhIU261xTE_bVAsA" />
+                    </Children>
+                  </Container>
+                  <Parameter id="S5rXkSEfjk2OWxg4uSjAcw" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="IIn4SWq32E6bylv04yjHcQ" isDefault="1" displayUnit="cm²">
+                    <Tags>
+                      <Tag value="Neighborhood: Plasma / Interstitial" />
+                      <Tag value="Small intestine  neighborhood" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="21" ref="0" bb="32" group="106" />
+                  </Parameter>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="cH-b4s3ZtkyWfFkEw1pDdQ" name="LowerIleum_int_LowerIleum_cell" description="Neighborhood between Small Intestine/Mucosa/Lower Ileum/Interstitial and Small Intestine/Mucosa/Lower Ileum/Intracellular" mode="Logical" containerType="Neighborhood" firstNeighbor="Wnba1ow11EO4EE9bl1feuQ" secondNeighbor="NJHSNYdpF0yRamDyRpn9Zw">
+                <Tags>
+                  <Tag value="Neighborhood: Interstitial / Intracellular" />
+                  <Tag value="Small intestine  neighborhood" />
+                </Tags>
+                <Children>
+                  <Container id="WXBbANcw7USYAIw_k_KxWA" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="W67LIaXVmkO6tv92kz_o4g" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="CDnoPurpsUuJ5R948GReCw" isDefault="1" displayUnit="cm/min">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="135" />
+                      </Parameter>
+                      <Parameter id="-fqoQaZUH0CrXG0rHp8Sgg" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="iYnVDTptR0OXWIAspZi4IA" isDefault="1" displayUnit="cm/min">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="133" />
+                      </Parameter>
+                      <Parameter id="Txuxdt8fTU-ZMzlpnT-ASQ" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="M2WXUlVpY0W18PhhdNB88Q" isDefault="1" displayUnit="l/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="TfzYc5MJGkmLdHTzucOzpw" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="70Te4TWLFEi68KKWZ6BTqA" isDefault="1" displayUnit="l/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="9AZailN9zEmqLFgdXn6GVA" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="BKtrNxW-HUuvhYiN4jYc6w" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="kKG4QVBSRkyhddZk5H9cOQ" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="hag-Xogdv02T-vXdvDwWkg" isDefault="1">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="147" />
+                      </Parameter>
+                      <Parameter id="6x5a8yS8e0SJGd-5LyjuYA" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cf5OHy-pE0-BjjqyfS_nTg" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+                      </Parameter>
+                      <Parameter id="z-jZoKL2T0WO2xdEbL-d4g" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="4BlVBMvtg0Gz7B9zQVORSw" isDefault="1">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Transport id="71WiNmr-4U--bZj72R0UBQ" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Transport" dimension="Amount per time" formula="06fMxQB_zkWbaECf_sUd-w" sourceAmount="6FE59Qje3k2TuiSXpSXvzg" targetAmount="K-XpbxOHZEWVtNyPrJeVHA" />
+                    </Children>
+                  </Container>
+                  <Parameter id="vd5pwXJ1EkGb6komyUDJzA" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="WNG0Asr5nUq7ATFnZ1L6-Q" isDefault="1" displayUnit="cm²">
+                    <Tags>
+                      <Tag value="Neighborhood: Interstitial / Intracellular" />
+                      <Tag value="Small intestine  neighborhood" />
+                    </Tags>
+                    <Info min="0" flag="122" seq="22" ref="0" bb="32" group="105" />
+                  </Parameter>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="rOeweGRmNUSEKLbaK23QRg" name="LowerIleum_pls_LowerIleum_bc" description="Neighborhood between Small Intestine/Mucosa/Lower Ileum/Plasma and Small Intestine/Mucosa/Lower Ileum/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="9tzwJZOJJ0-AQ1gsdsTzQA" secondNeighbor="kpS3W3QAK0i25MzZVfuS8g">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / BloodCells" />
+                  <Tag value="Small intestine  neighborhood" />
+                </Tags>
+                <Children>
+                  <Container id="8S8uAK-HwUmxUn3WDfjbmA" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="wffqM2QvvECGIcIZw4VzDQ" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="eEUry3MzKUmK_ii_WiY2gQ" sourceAmount="TC5L9nJpwkusWgAoYrAeGA" targetAmount="DaWlSCbKcUag3-1UfyXwhg" />
+                    </Children>
+                  </Container>
+                  <Parameter id="zq9BGY3Cs0qJ9adF85DOVg" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="2Tw7z-SsEE2uAH5c_SBrbw" isDefault="1" displayUnit="cm²">
+                    <Tags>
+                      <Tag value="Neighborhood: Plasma / BloodCells" />
+                      <Tag value="Small intestine  neighborhood" />
+                    </Tags>
+                    <Info min="0" flag="122" seq="25" ref="0" bb="32" group="104" />
+                  </Parameter>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="CwoyZL-VwEOc3p9iu2nnIA" name="LowerIleum_pls_LowerIleum_int" description="Neighborhood between Small Intestine/Mucosa/Lower Ileum/Plasma and Small Intestine/Mucosa/Lower Ileum/Interstitial" mode="Logical" containerType="Neighborhood" firstNeighbor="9tzwJZOJJ0-AQ1gsdsTzQA" secondNeighbor="Wnba1ow11EO4EE9bl1feuQ">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / Interstitial" />
+                  <Tag value="Small intestine  neighborhood" />
+                </Tags>
+                <Children>
+                  <Container id="onzdQrZ99UuEquidIwHD3w" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="AWM_7xS8N0qL9Hc-KbOwFQ" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
+                        <ValueOrigin id="49" source="Other" method="Assumption" description="Assumption: very fast exchange" />
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="134" />
+                      </Parameter>
+                      <Parameter id="O2Awdm2p10-amo7bEOJL0A" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="WO-8Vog5vUuNvOpjrIOoOg" isDefault="1">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="148" />
+                      </Parameter>
+                      <Transport id="PUH-WKg-OkWhpbpXqGORiw" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Transport" dimension="Amount per time" formula="i9qT1ErRu0Cz_9cvF_wwkw" sourceAmount="TC5L9nJpwkusWgAoYrAeGA" targetAmount="6FE59Qje3k2TuiSXpSXvzg" />
+                    </Children>
+                  </Container>
+                  <Parameter id="sARxp-uAsEmD1MScYJ4kMg" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="W5N5j6HzaUmyzgM39pPg4w" isDefault="1" displayUnit="cm²">
+                    <Tags>
+                      <Tag value="Neighborhood: Plasma / Interstitial" />
+                      <Tag value="Small intestine  neighborhood" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="22" ref="0" bb="32" group="106" />
+                  </Parameter>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="9fDXSU7SKkGZR52HPnm7fA" name="Caecum_int_Caecum_cell" description="Neighborhood between Large Intestine/Mucosa/Cecum/Interstitial and Large Intestine/Mucosa/Cecum/Intracellular" mode="Logical" containerType="Neighborhood" firstNeighbor="hd_e-QNvhEOYeLezeWUy1g" secondNeighbor="AKVKQTBp2USrIEs1XsdgtQ">
+                <Tags>
+                  <Tag value="Large intestine  neighborhood" />
+                  <Tag value="Neighborhood: Interstitial / Intracellular" />
+                </Tags>
+                <Children>
+                  <Container id="uqNkfCg3r0Cp3avy-hG5vg" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="yBeauP74JUyJROKvo0dXeg" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="CDnoPurpsUuJ5R948GReCw" isDefault="1" displayUnit="cm/min">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="135" />
+                      </Parameter>
+                      <Parameter id="tnW4Ih1Qi0S8YWJAVGdJQw" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="iYnVDTptR0OXWIAspZi4IA" isDefault="1" displayUnit="cm/min">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="133" />
+                      </Parameter>
+                      <Parameter id="HPC_HHv4bkSSIfYoRDU0MQ" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="M2WXUlVpY0W18PhhdNB88Q" isDefault="1" displayUnit="l/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="cg16pWzjtkuU-Gdm26l4xA" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="70Te4TWLFEi68KKWZ6BTqA" isDefault="1" displayUnit="l/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="saWnaZ6k3Um9LaODaDAKtg" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="k0b3OeP5JE6hec3YZe-x5A" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="irWbv2C_REWQfn9Pq191rA" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="6yDglQx-NUCYKz0COtLpbQ" isDefault="1">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="147" />
+                      </Parameter>
+                      <Parameter id="KUnTudc1oU-CzuJo6gHIUg" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cf5OHy-pE0-BjjqyfS_nTg" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+                      </Parameter>
+                      <Parameter id="pagYQXqGvU2BpSWcnz5WyQ" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="casC9bQa6kCW8WuZvRnfQQ" isDefault="1">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Transport id="0B8xGpif5kezeQ_LLtkBNg" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Transport" dimension="Amount per time" formula="Nz-coTl0_0Om04A8q9AQAA" sourceAmount="wPv27rZ--U2kepMWYgvO8w" targetAmount="_mNlhygPYk6in-N0aLpi3w" />
+                    </Children>
+                  </Container>
+                  <Parameter id="p7R2QxeMZ0q2Qpack_Yn7A" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="ibmur4yRQ0ObS4F49OGWiw" isDefault="1" displayUnit="cm²">
+                    <Tags>
+                      <Tag value="Large intestine  neighborhood" />
+                      <Tag value="Neighborhood: Interstitial / Intracellular" />
+                    </Tags>
+                    <Info min="0" flag="122" seq="23" ref="0" bb="32" group="105" />
+                  </Parameter>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="82wbBbdHwUKfHrX9MpN9Hw" name="Caecum_pls_Caecum_bc" description="Neighborhood between Large Intestine/Mucosa/Cecum/Plasma and Large Intestine/Mucosa/Cecum/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="mJ1VEhL0vEWlFO5jRJmtfA" secondNeighbor="0JvhwzGCx02WPt8g_nY3lg">
+                <Tags>
+                  <Tag value="Large intestine  neighborhood" />
+                  <Tag value="Neighborhood: Plasma / BloodCells" />
+                </Tags>
+                <Children>
+                  <Container id="6iJIN3HlB0qLRy9hC2DxlQ" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="7j3bOSM7ukit5JSOuvc9Gg" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="wH4kmI5KkkeCs_OgJJKzBg" sourceAmount="wao9GN6hn0eOf7hZ3UZj9w" targetAmount="o6NCkHAV3ECgxc8vuMn83w" />
+                    </Children>
+                  </Container>
+                  <Parameter id="eOcitGKl3kqpD2wtCMy7lg" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="kYM8DmQGBUqlKUM8VGNLOQ" isDefault="1" displayUnit="cm²">
+                    <Tags>
+                      <Tag value="Large intestine  neighborhood" />
+                      <Tag value="Neighborhood: Plasma / BloodCells" />
+                    </Tags>
+                    <Info min="0" flag="122" seq="26" ref="0" bb="32" group="104" />
+                  </Parameter>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="-EDSP4iExkmW0-HQ0U9RdQ" name="Caecum_pls_Caecum_int" description="Neighborhood between Large Intestine/Mucosa/Cecum/Plasma and Large Intestine/Mucosa/Cecum/Interstitial" mode="Logical" containerType="Neighborhood" firstNeighbor="mJ1VEhL0vEWlFO5jRJmtfA" secondNeighbor="hd_e-QNvhEOYeLezeWUy1g">
+                <Tags>
+                  <Tag value="Large intestine  neighborhood" />
+                  <Tag value="Neighborhood: Plasma / Interstitial" />
+                </Tags>
+                <Children>
+                  <Container id="2FqlunK1HECMXnWMYk0DvQ" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="sykRBP2-pUWFk-azR4FvTw" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
+                        <ValueOrigin id="49" source="Other" method="Assumption" description="Assumption: very fast exchange" />
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="134" />
+                      </Parameter>
+                      <Parameter id="LlQJWlMfLk26iZRVaR6bYg" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="WO-8Vog5vUuNvOpjrIOoOg" isDefault="1">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="148" />
+                      </Parameter>
+                      <Transport id="g9LL4TTda0mqdg1hVqqyjw" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Transport" dimension="Amount per time" formula="EWJhF-8iSE68y_wPwgtzvg" sourceAmount="wao9GN6hn0eOf7hZ3UZj9w" targetAmount="wPv27rZ--U2kepMWYgvO8w" />
+                    </Children>
+                  </Container>
+                  <Parameter id="zXBxle-QjkapEIZmRY7F7g" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="5QboJ0od9U2tg7dEQ10O3Q" isDefault="1" displayUnit="cm²">
+                    <Tags>
+                      <Tag value="Large intestine  neighborhood" />
+                      <Tag value="Neighborhood: Plasma / Interstitial" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="23" ref="0" bb="32" group="106" />
+                  </Parameter>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="NtbU8g5N6U2QJEWgB-BPOQ" name="ColonAscendens_int_ColonAscendens_cell" description="Neighborhood between Large Intestine/Mucosa/Colon Ascendens/Interstitial and Large Intestine/Mucosa/Colon Ascendens/Intracellular" mode="Logical" containerType="Neighborhood" firstNeighbor="WmJ-WsXVDEimc6NYz6O-CA" secondNeighbor="6GTdN--hKEqMH9mEmfYH6A">
+                <Tags>
+                  <Tag value="Large intestine  neighborhood" />
+                  <Tag value="Neighborhood: Interstitial / Intracellular" />
+                </Tags>
+                <Children>
+                  <Container id="-phter549kqoR1VFxXKN8g" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="RNq5q920ME2ZWtizHmubjQ" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="CDnoPurpsUuJ5R948GReCw" isDefault="1" displayUnit="cm/min">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="135" />
+                      </Parameter>
+                      <Parameter id="jQKYWFqs4kuC34flRcMaVg" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="iYnVDTptR0OXWIAspZi4IA" isDefault="1" displayUnit="cm/min">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="133" />
+                      </Parameter>
+                      <Parameter id="KtwFrmdFBEKK-zwTMM_Xag" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="M2WXUlVpY0W18PhhdNB88Q" isDefault="1" displayUnit="l/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="1AqqD9xGmkqAPN3nrPtyRg" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="70Te4TWLFEi68KKWZ6BTqA" isDefault="1" displayUnit="l/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="-BDy-bIWLU62_h0Dkty6qQ" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="gl7i4nQjtEyXqzw1nL8U3g" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="WMp7-XyIl0eWDzcoZCNDHA" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="yD-cnf1QKkenW67TE7mAkg" isDefault="1">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="147" />
+                      </Parameter>
+                      <Parameter id="Jk4ZZ80_YECzzzwL2TASZA" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cf5OHy-pE0-BjjqyfS_nTg" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+                      </Parameter>
+                      <Parameter id="trtP59tuhUugWM5jnpTqCQ" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="casC9bQa6kCW8WuZvRnfQQ" isDefault="1">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Transport id="6iZoBKWSxUazN17DnHKKog" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Transport" dimension="Amount per time" formula="LsciYmHu1UqpJi010C1lGQ" sourceAmount="MWQ_d9mBWUK4aYUyMUbKMA" targetAmount="KpXMMvTcfEGpXan02OjF7g" />
+                    </Children>
+                  </Container>
+                  <Parameter id="ZcTWE-C740ibKeZsmOdjHg" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="J8YLn2pXGkeonBO40TIPDQ" isDefault="1" displayUnit="cm²">
+                    <Tags>
+                      <Tag value="Large intestine  neighborhood" />
+                      <Tag value="Neighborhood: Interstitial / Intracellular" />
+                    </Tags>
+                    <Info min="0" flag="122" seq="24" ref="0" bb="32" group="105" />
+                  </Parameter>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="fM_DSi40h0OjaM54xOWZkA" name="ColonAscendens_pls_ColonAscendens_bc" description="Neighborhood between Large Intestine/Mucosa/Colon Ascendens/Plasma and Large Intestine/Mucosa/Colon Ascendens/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="3IX6ZvrqBE2RAum9H4_lpw" secondNeighbor="fY5-Tz2cDk-SgbOQbDDDkQ">
+                <Tags>
+                  <Tag value="Large intestine  neighborhood" />
+                  <Tag value="Neighborhood: Plasma / BloodCells" />
+                </Tags>
+                <Children>
+                  <Container id="TGJtND61qUOP_F_RjgESqQ" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="6DmAnaL2DkakXYiGkCTzsA" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="pH-ESf0k2UaM6ARB3AF0rw" sourceAmount="gdVc1LkaqUKWwNPeWpWNFA" targetAmount="wSMMb12yZkCZl46czAda2g" />
+                    </Children>
+                  </Container>
+                  <Parameter id="zc5DNbz4V0GOPNpQMw_3Hg" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="ixkTQpOqHkWDVG9V92K50w" isDefault="1" displayUnit="cm²">
+                    <Tags>
+                      <Tag value="Large intestine  neighborhood" />
+                      <Tag value="Neighborhood: Plasma / BloodCells" />
+                    </Tags>
+                    <Info min="0" flag="122" seq="27" ref="0" bb="32" group="104" />
+                  </Parameter>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="CZ0liRgbmU2C8CJyDoFOzQ" name="ColonAscendens_pls_ColonAscendens_int" description="Neighborhood between Large Intestine/Mucosa/Colon Ascendens/Plasma and Large Intestine/Mucosa/Colon Ascendens/Interstitial" mode="Logical" containerType="Neighborhood" firstNeighbor="3IX6ZvrqBE2RAum9H4_lpw" secondNeighbor="WmJ-WsXVDEimc6NYz6O-CA">
+                <Tags>
+                  <Tag value="Large intestine  neighborhood" />
+                  <Tag value="Neighborhood: Plasma / Interstitial" />
+                </Tags>
+                <Children>
+                  <Container id="pUaZedRJTk6fL7vxgRLE6A" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="qe0w39Dq5UiN4zvRao5_sA" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
+                        <ValueOrigin id="49" source="Other" method="Assumption" description="Assumption: very fast exchange" />
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="134" />
+                      </Parameter>
+                      <Parameter id="tfynju5JxUy35sCnA88ekQ" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="WO-8Vog5vUuNvOpjrIOoOg" isDefault="1">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="148" />
+                      </Parameter>
+                      <Transport id="1aHZPKAKgU6HaWbZ5fDBBQ" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Transport" dimension="Amount per time" formula="M-_fcrvqUUWT93aTsHRVOw" sourceAmount="gdVc1LkaqUKWwNPeWpWNFA" targetAmount="MWQ_d9mBWUK4aYUyMUbKMA" />
+                    </Children>
+                  </Container>
+                  <Parameter id="AYkW53cZsk-yyODIPE0goQ" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="5AebhjFkEEuDikfjpR9lcA" isDefault="1" displayUnit="cm²">
+                    <Tags>
+                      <Tag value="Large intestine  neighborhood" />
+                      <Tag value="Neighborhood: Plasma / Interstitial" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="24" ref="0" bb="32" group="106" />
+                  </Parameter>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="oeZtpYkQV061gq5pyxmnkw" name="ColonTransversum_int_ColonTransversum_cell" description="Neighborhood between Large Intestine/Mucosa/Colon Transversum/Interstitial and Large Intestine/Mucosa/Colon Transversum/Intracellular" mode="Logical" containerType="Neighborhood" firstNeighbor="Bu6xSFBmck2Ur0vpd2XWDA" secondNeighbor="K_DTJO3kn0WFG-dPb6WJzw">
+                <Tags>
+                  <Tag value="Large intestine  neighborhood" />
+                  <Tag value="Neighborhood: Interstitial / Intracellular" />
+                </Tags>
+                <Children>
+                  <Container id="ABio1XTGxE2jI7ugtkQxGQ" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="pB18pLQZgEuSyNRj8aGgFA" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="CDnoPurpsUuJ5R948GReCw" isDefault="1" displayUnit="cm/min">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="135" />
+                      </Parameter>
+                      <Parameter id="NNT2wpDFbEudHu5Em2nkBA" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="iYnVDTptR0OXWIAspZi4IA" isDefault="1" displayUnit="cm/min">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="133" />
+                      </Parameter>
+                      <Parameter id="dfE9n8xEqE-wLXsUZcN73g" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="M2WXUlVpY0W18PhhdNB88Q" isDefault="1" displayUnit="l/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="7Pt6e86Y1U6w770nyh-efg" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="70Te4TWLFEi68KKWZ6BTqA" isDefault="1" displayUnit="l/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="lCZ2gZm7HUOhwEahOSMDNw" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="hMfdIziTcUSlW-2GwjFE2w" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="bJoLkKAOYE-BsSgtI0CA3w" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="KPuqZPGbw0CChmyyK9wzFg" isDefault="1">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="147" />
+                      </Parameter>
+                      <Parameter id="0xyXjNEBAEuqHugeKamlAA" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cf5OHy-pE0-BjjqyfS_nTg" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+                      </Parameter>
+                      <Parameter id="Pv0sWSN4gkW90oPWil3sQQ" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="casC9bQa6kCW8WuZvRnfQQ" isDefault="1">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Transport id="DWUqxg1IaEKvmeW2a0apCQ" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Transport" dimension="Amount per time" formula="PMoYufs4P0uN3Zg0zQAlJw" sourceAmount="nD6Ye-w4p0OvnbeePD57qQ" targetAmount="WXFcEn0RZU-hAd-SnN8AKQ" />
+                    </Children>
+                  </Container>
+                  <Parameter id="hyagoJnYgEGgyuWJg7D8SQ" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="XJC5DwsAeEmYzTFpqa3p-Q" isDefault="1" displayUnit="cm²">
+                    <Tags>
+                      <Tag value="Large intestine  neighborhood" />
+                      <Tag value="Neighborhood: Interstitial / Intracellular" />
+                    </Tags>
+                    <Info min="0" flag="122" seq="25" ref="0" bb="32" group="105" />
+                  </Parameter>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="mmBcQ0nwSUOYNmDwtXpAgQ" name="ColonTransversum_pls_ColonTransversum_bc" description="Neighborhood between Large Intestine/Mucosa/Colon Transversum/Plasma and Large Intestine/Mucosa/Colon Transversum/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="VsgWfVKXeUyOdIOdNnIPwA" secondNeighbor="hGPbabIhQ0KWH06UQE2RbQ">
+                <Tags>
+                  <Tag value="Large intestine  neighborhood" />
+                  <Tag value="Neighborhood: Plasma / BloodCells" />
+                </Tags>
+                <Children>
+                  <Container id="6Ywn9q_RLEe5zQsAa7szDg" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="j5Ywk0M3kkuUAUGKQBWOpQ" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="pkY0hFQdTkm2F246IVfVfw" sourceAmount="pVKp11hx2E6R7VPiZbwHDg" targetAmount="B0qtuVLp9EKHz5VWRWskcw" />
+                    </Children>
+                  </Container>
+                  <Parameter id="6fxB1nSSo0qQ6fSfOmUPJw" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="lYxOIBmjHUiUPPkodzzIdQ" isDefault="1" displayUnit="cm²">
+                    <Tags>
+                      <Tag value="Large intestine  neighborhood" />
+                      <Tag value="Neighborhood: Plasma / BloodCells" />
+                    </Tags>
+                    <Info min="0" flag="122" seq="28" ref="0" bb="32" group="104" />
+                  </Parameter>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="816dRTnNCUa_afBj19JTqA" name="ColonTransversum_pls_ColonTransversum_int" description="Neighborhood between Large Intestine/Mucosa/Colon Transversum/Plasma and Large Intestine/Mucosa/Colon Transversum/Interstitial" mode="Logical" containerType="Neighborhood" firstNeighbor="VsgWfVKXeUyOdIOdNnIPwA" secondNeighbor="Bu6xSFBmck2Ur0vpd2XWDA">
+                <Tags>
+                  <Tag value="Large intestine  neighborhood" />
+                  <Tag value="Neighborhood: Plasma / Interstitial" />
+                </Tags>
+                <Children>
+                  <Container id="ud6NEKBJ9kGZ4pLh9Bjbbw" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="i9xK9Kioz0S2jcsemfJd-w" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
+                        <ValueOrigin id="49" source="Other" method="Assumption" description="Assumption: very fast exchange" />
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="134" />
+                      </Parameter>
+                      <Parameter id="Ddc-teJsEkSsMjGKYguVvw" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="WO-8Vog5vUuNvOpjrIOoOg" isDefault="1">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="148" />
+                      </Parameter>
+                      <Transport id="WshDa0jkZked6_jGcpSx7w" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Transport" dimension="Amount per time" formula="onynZewg5Ei7xLlQ3SAw6A" sourceAmount="pVKp11hx2E6R7VPiZbwHDg" targetAmount="nD6Ye-w4p0OvnbeePD57qQ" />
+                    </Children>
+                  </Container>
+                  <Parameter id="Uef7a87-m0ewz1f5K1bX6Q" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="_9ySIuQQP02JxuKd1uSXHQ" isDefault="1" displayUnit="cm²">
+                    <Tags>
+                      <Tag value="Large intestine  neighborhood" />
+                      <Tag value="Neighborhood: Plasma / Interstitial" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="25" ref="0" bb="32" group="106" />
+                  </Parameter>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="CKMvwZA4EkaLpnBliSFDUg" name="ColonDescendens_int_ColonDescendens_cell" description="Neighborhood between Large Intestine/Mucosa/Colon Descendens/Interstitial and Large Intestine/Mucosa/Colon Descendens/Intracellular" mode="Logical" containerType="Neighborhood" firstNeighbor="zynzBIZtn06uGL5gZqZXTA" secondNeighbor="ElVZCkQsfUuMh4sC6i18Uw">
+                <Tags>
+                  <Tag value="Large intestine  neighborhood" />
+                  <Tag value="Neighborhood: Interstitial / Intracellular" />
+                </Tags>
+                <Children>
+                  <Container id="8ikHK-LWrEybHdirH06-dQ" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="M3otRbNW2U6-fQjN_FX18Q" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="CDnoPurpsUuJ5R948GReCw" isDefault="1" displayUnit="cm/min">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="135" />
+                      </Parameter>
+                      <Parameter id="A284DJE2MEyzBrmEoByxfA" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="iYnVDTptR0OXWIAspZi4IA" isDefault="1" displayUnit="cm/min">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="133" />
+                      </Parameter>
+                      <Parameter id="FotJ5PrNtU6SWej1rMSIUQ" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="M2WXUlVpY0W18PhhdNB88Q" isDefault="1" displayUnit="l/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="fL9JWUX7bUiIufZGHRgUmw" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="70Te4TWLFEi68KKWZ6BTqA" isDefault="1" displayUnit="l/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="7BiL7RiMzkm5X_h6hxHcKA" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="FiNTD8zn306uqpJsSR4sXg" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="RlWBTFBb0kmbJBCuKTnXUg" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Uv99S-vtVUmD4seC0C3saQ" isDefault="1">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="147" />
+                      </Parameter>
+                      <Parameter id="5XcG4U2ZjUSOQHP2dQ2NuQ" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cf5OHy-pE0-BjjqyfS_nTg" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+                      </Parameter>
+                      <Parameter id="7H3FXkDFMU2Fu-jN4ndYBw" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="casC9bQa6kCW8WuZvRnfQQ" isDefault="1">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Transport id="rzvGvB0plEuvWhccpcboVw" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Transport" dimension="Amount per time" formula="Varx1DAyREGqWJwfXmGoeA" sourceAmount="fcU0fpiyb0qPeHcGHZwukg" targetAmount="RLjjqtjktUmVEZwhOKiC5w" />
+                    </Children>
+                  </Container>
+                  <Parameter id="GsGFjyinLECl0-gByP4bKw" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="dpymAULlWE-x3Uy67Bn4xA" isDefault="1" displayUnit="cm²">
+                    <Tags>
+                      <Tag value="Large intestine  neighborhood" />
+                      <Tag value="Neighborhood: Interstitial / Intracellular" />
+                    </Tags>
+                    <Info min="0" flag="122" seq="26" ref="0" bb="32" group="105" />
+                  </Parameter>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="Q15M3IEoa0iYIbFev-pUIQ" name="ColonDescendens_pls_ColonDescendens_bc" description="Neighborhood between Large Intestine/Mucosa/Colon Descendens/Plasma and Large Intestine/Mucosa/Colon Descendens/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="P-Rbv420dU-i31SJUJoEVQ" secondNeighbor="F1M6UAdAQ0-_GF-yyYZDGw">
+                <Tags>
+                  <Tag value="Large intestine  neighborhood" />
+                  <Tag value="Neighborhood: Plasma / BloodCells" />
+                </Tags>
+                <Children>
+                  <Container id="sGyvW_gdQUic5NV-1adyyA" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="7s_mED8pA0Os1YybY2-Rug" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="CKEZwjcBEE-d8Q9aTIRFFg" sourceAmount="482dd-88D02lBVskSk8Wsw" targetAmount="BMXInBiGn0mr_9IW4lNpFA" />
+                    </Children>
+                  </Container>
+                  <Parameter id="sx9s9u1_XkmZE-aBlmy9cg" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="cQnmk7GmnkyONd_keyWhNg" isDefault="1" displayUnit="cm²">
+                    <Tags>
+                      <Tag value="Large intestine  neighborhood" />
+                      <Tag value="Neighborhood: Plasma / BloodCells" />
+                    </Tags>
+                    <Info min="0" flag="122" seq="29" ref="0" bb="32" group="104" />
+                  </Parameter>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="XhS9NQr0EkWcPGJ3usszBQ" name="ColonDescendens_pls_ColonDescendens_int" description="Neighborhood between Large Intestine/Mucosa/Colon Descendens/Plasma and Large Intestine/Mucosa/Colon Descendens/Interstitial" mode="Logical" containerType="Neighborhood" firstNeighbor="P-Rbv420dU-i31SJUJoEVQ" secondNeighbor="zynzBIZtn06uGL5gZqZXTA">
+                <Tags>
+                  <Tag value="Large intestine  neighborhood" />
+                  <Tag value="Neighborhood: Plasma / Interstitial" />
+                </Tags>
+                <Children>
+                  <Container id="lVMoS1Y_skeHjF9w9i1IzA" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="cWeedVwcpky3rXR8PRXoGw" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
+                        <ValueOrigin id="49" source="Other" method="Assumption" description="Assumption: very fast exchange" />
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="134" />
+                      </Parameter>
+                      <Parameter id="2g0hot0wCEqmHDjb1nMiQg" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="WO-8Vog5vUuNvOpjrIOoOg" isDefault="1">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="148" />
+                      </Parameter>
+                      <Transport id="79zHciooiEeh0GO-0oIw0g" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Transport" dimension="Amount per time" formula="4FZbuYdeLk2lvHuwv9QndQ" sourceAmount="482dd-88D02lBVskSk8Wsw" targetAmount="fcU0fpiyb0qPeHcGHZwukg" />
+                    </Children>
+                  </Container>
+                  <Parameter id="NYWmnsfIa0GFXLyQTBa7Lw" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="oyN3-YpjtE6dj4ckdBHORQ" isDefault="1" displayUnit="cm²">
+                    <Tags>
+                      <Tag value="Large intestine  neighborhood" />
+                      <Tag value="Neighborhood: Plasma / Interstitial" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="26" ref="0" bb="32" group="106" />
+                  </Parameter>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="juZWxHMJ40eoRCdGiZHX8Q" name="ColonSigmoid_int_ColonSigmoid_cell" description="Neighborhood between Large Intestine/Mucosa/Colon Sigmoid/Interstitial and Large Intestine/Mucosa/Colon Sigmoid/Intracellular" mode="Logical" containerType="Neighborhood" firstNeighbor="kBF-HCFoIEuAti28q7xE3A" secondNeighbor="PSUOMlWl50mlkNqBQIQxiw">
+                <Tags>
+                  <Tag value="Large intestine  neighborhood" />
+                  <Tag value="Neighborhood: Interstitial / Intracellular" />
+                </Tags>
+                <Children>
+                  <Container id="1k97fZcMZ02_cXTWWuOjsA" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="s0hAe20fwkq4XeDWsqvzeA" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="CDnoPurpsUuJ5R948GReCw" isDefault="1" displayUnit="cm/min">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="135" />
+                      </Parameter>
+                      <Parameter id="s16yY3S_-EORv0bxbzWIVg" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="iYnVDTptR0OXWIAspZi4IA" isDefault="1" displayUnit="cm/min">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="133" />
+                      </Parameter>
+                      <Parameter id="mbimZb5yy0aCYPb7DlfZXA" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="M2WXUlVpY0W18PhhdNB88Q" isDefault="1" displayUnit="l/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="c2RqJWdHJkeGBLlfmCjBJA" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="70Te4TWLFEi68KKWZ6BTqA" isDefault="1" displayUnit="l/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="7EzFjMe_PUunVGgl_VNklw" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="VHXU8On9-kmO295QB4s6cw" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="jsc9F0ar2Easne84CkGvYA" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="3oTiJI10C02purw5BcbjZQ" isDefault="1">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="147" />
+                      </Parameter>
+                      <Parameter id="P-c5POPHEkufgrmIfgLxXA" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cf5OHy-pE0-BjjqyfS_nTg" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+                      </Parameter>
+                      <Parameter id="Y5F0AUaxW0OhTufLtpG7yg" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="casC9bQa6kCW8WuZvRnfQQ" isDefault="1">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Transport id="uh75AoDgwEaMwrvG_p5-kw" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Transport" dimension="Amount per time" formula="2W3fhd8Ps0i9oC_rLKgiZA" sourceAmount="2XI3vkMQnkSqOJvfSvvvqQ" targetAmount="hAH4gRJJZU-e1rGkz_z79A" />
+                    </Children>
+                  </Container>
+                  <Parameter id="fHBrPWB0WkCMNwbkrP8RWw" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="L-sqYt9MzUKB8YzBV1M45Q" isDefault="1" displayUnit="cm²">
+                    <Tags>
+                      <Tag value="Large intestine  neighborhood" />
+                      <Tag value="Neighborhood: Interstitial / Intracellular" />
+                    </Tags>
+                    <Info min="0" flag="122" seq="27" ref="0" bb="32" group="105" />
+                  </Parameter>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="k1OUJlLHfkuzRgU0zLJWlw" name="ColonSigmoid_pls_ColonSigmoid_bc" description="Neighborhood between Large Intestine/Mucosa/Colon Sigmoid/Plasma and Large Intestine/Mucosa/Colon Sigmoid/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="XdIMAdC9gUGtpu_ZPQO26A" secondNeighbor="LEpMQdfgRkWrirgrcKIj7A">
+                <Tags>
+                  <Tag value="Large intestine  neighborhood" />
+                  <Tag value="Neighborhood: Plasma / BloodCells" />
+                </Tags>
+                <Children>
+                  <Container id="bY-iDTSSykmbxBe1EBJpyA" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="eAViInHD3kCjW13q93g0-A" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="v2qwebfXN0S-8gbJVHXmJw" sourceAmount="RfGZnC_3Ck6c4ycMzqk92Q" targetAmount="KCragzk5OEWZZOrYQdbBjw" />
+                    </Children>
+                  </Container>
+                  <Parameter id="dQ7EsQY_wUyqUT3oMKDJBw" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="1LKm9z2vGUeZjK74e87PmQ" isDefault="1" displayUnit="cm²">
+                    <Tags>
+                      <Tag value="Large intestine  neighborhood" />
+                      <Tag value="Neighborhood: Plasma / BloodCells" />
+                    </Tags>
+                    <Info min="0" flag="122" seq="30" ref="0" bb="32" group="104" />
+                  </Parameter>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="6BXQpzicGkiihJ1pL2iH5g" name="ColonSigmoid_pls_ColonSigmoid_int" description="Neighborhood between Large Intestine/Mucosa/Colon Sigmoid/Plasma and Large Intestine/Mucosa/Colon Sigmoid/Interstitial" mode="Logical" containerType="Neighborhood" firstNeighbor="XdIMAdC9gUGtpu_ZPQO26A" secondNeighbor="kBF-HCFoIEuAti28q7xE3A">
+                <Tags>
+                  <Tag value="Large intestine  neighborhood" />
+                  <Tag value="Neighborhood: Plasma / Interstitial" />
+                </Tags>
+                <Children>
+                  <Container id="hrVUzeI6wEqH8GekL9UMvg" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="6Z0_-TPd10mC365nPunj3g" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
+                        <ValueOrigin id="49" source="Other" method="Assumption" description="Assumption: very fast exchange" />
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="134" />
+                      </Parameter>
+                      <Parameter id="IR-A4NlR2kmcEnod38Y7Ag" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="WO-8Vog5vUuNvOpjrIOoOg" isDefault="1">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="148" />
+                      </Parameter>
+                      <Transport id="9bAdZyqEEUajw0XGSZcqRw" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Transport" dimension="Amount per time" formula="QRLLDesa8kiMB81ndI3iwg" sourceAmount="RfGZnC_3Ck6c4ycMzqk92Q" targetAmount="2XI3vkMQnkSqOJvfSvvvqQ" />
+                    </Children>
+                  </Container>
+                  <Parameter id="ld1jNGmQjE6E0mDLvJ_rRQ" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="mXOpr9T77k-me6wzcSWzdA" isDefault="1" displayUnit="cm²">
+                    <Tags>
+                      <Tag value="Large intestine  neighborhood" />
+                      <Tag value="Neighborhood: Plasma / Interstitial" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="27" ref="0" bb="32" group="106" />
+                  </Parameter>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="oLa0fhpH8UiMjKUN2td8vw" name="Rectum_int_Rectum_cell" description="Neighborhood between Large Intestine/Mucosa/Rectum/Interstitial and Large Intestine/Mucosa/Rectum/Intracellular" mode="Logical" containerType="Neighborhood" firstNeighbor="EicGUlMO106zYp-0WDBzYA" secondNeighbor="FM81ONq2DEuyLvEEZVywLg">
+                <Tags>
+                  <Tag value="Large intestine  neighborhood" />
+                  <Tag value="Neighborhood: Interstitial / Intracellular" />
+                </Tags>
+                <Children>
+                  <Container id="eaAy41589EipnZYZR3s7bA" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="vXBpnwQWhkeTogfyGvqQPQ" name="P (interstitial-&gt;intracellular)" description="Permeability from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="CDnoPurpsUuJ5R948GReCw" isDefault="1" displayUnit="cm/min">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="135" />
+                      </Parameter>
+                      <Parameter id="dtXvrBk7q0SIPEvpghKTBQ" name="P (intracellular-&gt;interstitial)" description="Permeability from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="iYnVDTptR0OXWIAspZi4IA" isDefault="1" displayUnit="cm/min">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="133" />
+                      </Parameter>
+                      <Parameter id="0NRN6zeXwUeBcxmU5SoWXA" name="P*SA interstitial -&gt; intracellular" description="Permeability surface area product from interstitial to intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="M2WXUlVpY0W18PhhdNB88Q" isDefault="1" displayUnit="l/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="p4FpFOYGekmtc5tUhTqxBg" name="P*SA intracellular -&gt; interstitial" description="Permeability surface area product from intracellular to interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Flow" quantityType="Parameter" negativeValuesAllowed="1" formula="70Te4TWLFEi68KKWZ6BTqA" isDefault="1" displayUnit="l/min">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="DKcs1-hC1US9v1fdK38JHQ" name="P_cell_int_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="iBPGCnS-QEmWMla5E1DxPQ" name="P_int_cell_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="rCmdiNXNyE-0mdpmc67osA" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="1EL6-LZZhUSJHQ2Qwi8Zsg" isDefault="1">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="147" />
+                      </Parameter>
+                      <Parameter id="zU5YzVdvcEOl8HZ3eTj1CQ" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cf5OHy-pE0-BjjqyfS_nTg" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+                      </Parameter>
+                      <Parameter id="LA31N67q0UOarxnkichEvQ" name="Partition coefficient (interstitial/water)" description="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="casC9bQa6kCW8WuZvRnfQQ" isDefault="1">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Transport id="sKdS7SKRwEyH-TyriADVOw" name="PassiveDiffusionInt2Cell" description="Passive diffusion to cell" mode="Logical" containerType="Transport" dimension="Amount per time" formula="D70Xm5WadEa_iueVW6qWTg" sourceAmount="0bLMlGlF4kSZBbtTMFiDZw" targetAmount="IXiI7k4TAkiRJ08hJByC7A" />
+                    </Children>
+                  </Container>
+                  <Parameter id="Vk6AUffl3keY6CnpuPupGQ" name="Surface area (interstitial/intracellular)" description="Surface area between interstitial and intracellular space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="eB0t_VHEfEiTAyIHG28cTg" isDefault="1" displayUnit="cm²">
+                    <Tags>
+                      <Tag value="Large intestine  neighborhood" />
+                      <Tag value="Neighborhood: Interstitial / Intracellular" />
+                    </Tags>
+                    <Info min="0" flag="122" seq="28" ref="0" bb="32" group="105" />
+                  </Parameter>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="Lcjxpfs1KkegyW24DY11Lg" name="Rectum_pls_Rectum_bc" description="Neighborhood between Large Intestine/Mucosa/Rectum/Plasma and Large Intestine/Mucosa/Rectum/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="0CSP90W06Uu1NGW7pHqKUQ" secondNeighbor="aeMJUV5deEqPjiwgzRk9Sw">
+                <Tags>
+                  <Tag value="Large intestine  neighborhood" />
+                  <Tag value="Neighborhood: Plasma / BloodCells" />
+                </Tags>
+                <Children>
+                  <Container id="gCSDdrSi10WDbF1A5Md3xw" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="gMrSlzrU5UeLn78s13nguA" name="PassiveDiffusionPl2RBC" description="Passive diffusion to blood cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="76gmiyfDQE-OSreJkyqCKQ" sourceAmount="8pkBuuXtZUSHRQVga9r96Q" targetAmount="KO0_pqb3mkWfWurFI6aujA" />
+                    </Children>
+                  </Container>
+                  <Parameter id="JWdVzpF92UGWZXYE-LEn3A" name="Surface area (blood cells/plasma)" description="Surface area between blood cells and plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="CGVz9RwlkkmhEBagYfYWvA" isDefault="1" displayUnit="cm²">
+                    <Tags>
+                      <Tag value="Large intestine  neighborhood" />
+                      <Tag value="Neighborhood: Plasma / BloodCells" />
+                    </Tags>
+                    <Info min="0" flag="122" seq="31" ref="0" bb="32" group="104" />
+                  </Parameter>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="b1JAsjpTokmyfGh7dqol5g" name="Rectum_pls_Rectum_int" description="Neighborhood between Large Intestine/Mucosa/Rectum/Plasma and Large Intestine/Mucosa/Rectum/Interstitial" mode="Logical" containerType="Neighborhood" firstNeighbor="0CSP90W06Uu1NGW7pHqKUQ" secondNeighbor="EicGUlMO106zYp-0WDBzYA">
+                <Tags>
+                  <Tag value="Large intestine  neighborhood" />
+                  <Tag value="Neighborhood: Plasma / Interstitial" />
+                </Tags>
+                <Children>
+                  <Container id="yAe9aIpUiEu3TkjaSeKkGA" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="jRy7z0otDEumjIaWdlPLBA" name="P (plasma&lt;-&gt;interstitial)" description="Permeability between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="10" displayUnit="cm/min">
+                        <ValueOrigin id="49" source="Other" method="Assumption" description="Assumption: very fast exchange" />
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="134" />
+                      </Parameter>
+                      <Parameter id="broglWRZKkG2Tznj3fDdnQ" name="Partition coefficient (interstitial/plasma)" description="Partition coefficient between interstitial space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="WO-8Vog5vUuNvOpjrIOoOg" isDefault="1">
+                        <Info min="0" flag="122" seq="1" ref="0" bb="2" group="148" />
+                      </Parameter>
+                      <Transport id="RRrKVG8cw06cWZljE1oYhg" name="PassiveDiffusionPl2Int" description="Passive diffusion from plasma to interstitial space" mode="Logical" containerType="Transport" dimension="Amount per time" formula="98K04EygCkWCiycFKQsCCA" sourceAmount="8pkBuuXtZUSHRQVga9r96Q" targetAmount="0bLMlGlF4kSZBbtTMFiDZw" />
+                    </Children>
+                  </Container>
+                  <Parameter id="SeKkFC2SNkiUC_A5VY10QA" name="Surface area (plasma/interstitial)" description="Surface area between plasma and interstitial space" icon="Parameter" persistable="0" isFixedValue="0" dim="Area" quantityType="Parameter" negativeValuesAllowed="1" formula="LLKBDcFmgkOvcXUkXF77JA" isDefault="1" displayUnit="cm²">
+                    <Tags>
+                      <Tag value="Large intestine  neighborhood" />
+                      <Tag value="Neighborhood: Plasma / Interstitial" />
+                    </Tags>
+                    <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                    <Info min="0" flag="122" seq="28" ref="0" bb="32" group="106" />
+                  </Parameter>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="_Wi3MM-0nkuvZgINiRksng" name="ArterialBlood_bc_Bone_bc" description="Neighborhood between Arterial Blood/Blood Cells and Bone/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="FtxmOVy3hEyMCuullB4l-A" secondNeighbor="86rQQuQVRUyJz9KAJF1KEA">
+                <Tags>
+                  <Tag value="Neighborhood: BloodCells / BloodCells" />
+                </Tags>
+                <Children>
+                  <Container id="oJ4QdHZjkEWQSGtA13eQOw" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="9RCb56Al2UCCdYwWh_3_wQ" name="MassTransferBloodPool2OrgRBC" description="Mass transfer from ArterialBlood: BloodCells to organ: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="z3CmUKM2B0KHA4bILOhzTQ" sourceAmount="gVpumttaHUG12bviSHchzw" targetAmount="0bzVR1eNmUGmMRhYoqacIA" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="Cq77HjYNFECNKSD1dkZqqQ" name="ArterialBlood_bc_Brain_bc" description="Neighborhood between Arterial Blood/Blood Cells and Brain/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="FtxmOVy3hEyMCuullB4l-A" secondNeighbor="ZZ7zER2x_UqPUjGeqMMoNA">
+                <Tags>
+                  <Tag value="Neighborhood: BloodCells / BloodCells" />
+                </Tags>
+                <Children>
+                  <Container id="zYJLgX_fFkWAYyiCLCozBQ" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="lW4n_M1QqkOSVvLramYSaw" name="MassTransferBloodPool2OrgRBC" description="Mass transfer from ArterialBlood: BloodCells to organ: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="fDS1hFPk6kW184R3xWL35g" sourceAmount="gVpumttaHUG12bviSHchzw" targetAmount="XTM3f4NFL0OOb4D7deYV6g" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="shHwGV_0eUqWfOg99X8Fyw" name="ArterialBlood_bc_Fat_bc" description="Neighborhood between Arterial Blood/Blood Cells and Fat/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="FtxmOVy3hEyMCuullB4l-A" secondNeighbor="NZxOvgCsl0KK1TCHgZbMYg">
+                <Tags>
+                  <Tag value="Neighborhood: BloodCells / BloodCells" />
+                </Tags>
+                <Children>
+                  <Container id="y5Ua9gRQWkqhUMPrhY9Oqg" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="hjiDubwzckSvjP9W19-rkQ" name="MassTransferBloodPool2OrgRBC" description="Mass transfer from ArterialBlood: BloodCells to organ: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="IFAJE40R9EahZmXtutNAXg" sourceAmount="gVpumttaHUG12bviSHchzw" targetAmount="VyJX6uklU0KkdB4Y0-tVow" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="5GDNVXTbj0K4DHWXOZxgwg" name="ArterialBlood_bc_Gonads_bc" description="Neighborhood between Arterial Blood/Blood Cells and Gonads/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="FtxmOVy3hEyMCuullB4l-A" secondNeighbor="gC60yfPKTkqclHndWv0AHA">
+                <Tags>
+                  <Tag value="Neighborhood: BloodCells / BloodCells" />
+                </Tags>
+                <Children>
+                  <Container id="JxOv2s4wJEeU9VlCiF_bXQ" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="w2WFcohSQ0elUlRvit2eMw" name="MassTransferBloodPool2OrgRBC" description="Mass transfer from ArterialBlood: BloodCells to organ: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="WsxlFfHnZEmAbkQICIctcA" sourceAmount="gVpumttaHUG12bviSHchzw" targetAmount="LSqLfNMDVk2WXiC6nghR2g" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="ZE-8FNOVDE2MX6uKNgTHEg" name="ArterialBlood_bc_Heart_bc" description="Neighborhood between Arterial Blood/Blood Cells and Heart/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="FtxmOVy3hEyMCuullB4l-A" secondNeighbor="25NddIAf-0mKNVC2gSD5nA">
+                <Tags>
+                  <Tag value="Neighborhood: BloodCells / BloodCells" />
+                </Tags>
+                <Children>
+                  <Container id="V_pRe5gDXEmeMpVWf1ramA" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="86vgylCYXEiT9OvbuOkbKw" name="MassTransferBloodPool2OrgRBC" description="Mass transfer from ArterialBlood: BloodCells to organ: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="wfrV_RGEDE6gvzMnOIrKjQ" sourceAmount="gVpumttaHUG12bviSHchzw" targetAmount="N9LBQ4qehUmSiJEcITEdVA" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="FGFCrxEfD0u5yQl9tqlFKg" name="ArterialBlood_bc_Kidney_bc" description="Neighborhood between Arterial Blood/Blood Cells and Kidney/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="FtxmOVy3hEyMCuullB4l-A" secondNeighbor="bmGYwuq6LESERUPPeoFDew">
+                <Tags>
+                  <Tag value="Neighborhood: BloodCells / BloodCells" />
+                </Tags>
+                <Children>
+                  <Container id="Ae3paSOZEEi3mBRMBoYG6g" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="kCDW30qXtEW-JkVFb9dpxQ" name="MassTransferBloodPool2OrgRBC" description="Mass transfer from ArterialBlood: BloodCells to organ: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="dwXKUpLwGU6U5-K8sKC1ww" sourceAmount="gVpumttaHUG12bviSHchzw" targetAmount="b5Rk0ZUhO0SbfQmNBmcpOA" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="RAnQ8YP1kUazGTPC5rsIAw" name="ArterialBlood_bc_LargeIntestine_bc" description="Neighborhood between Arterial Blood/Blood Cells and Large Intestine/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="FtxmOVy3hEyMCuullB4l-A" secondNeighbor="7kXmyJZiGkOucBYhYbZiPg">
+                <Tags>
+                  <Tag value="Neighborhood: BloodCells / BloodCells" />
+                </Tags>
+                <Children>
+                  <Container id="xMYvvextpECLX3ve6rx4eg" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="k_M0zinxw025_lsnDJ3YEg" name="MassTransferBloodPool2OrgRBC" description="Mass transfer from ArterialBlood: BloodCells to organ: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="RqX5lW5YfEGtbO7vbl_gUw" sourceAmount="gVpumttaHUG12bviSHchzw" targetAmount="9rqXdL0WmEOIxAFlIbki9w" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="39X9rD1SUEW_YP28MKfcBg" name="ArterialBlood_bc_Muscle_bc" description="Neighborhood between Arterial Blood/Blood Cells and Muscle/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="FtxmOVy3hEyMCuullB4l-A" secondNeighbor="YrNyyl3qek2c21v3mmypBA">
+                <Tags>
+                  <Tag value="Neighborhood: BloodCells / BloodCells" />
+                </Tags>
+                <Children>
+                  <Container id="pRFD4yD1Lk26fySQDRjvQg" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="SaXrjEv50EyrF_M4e59DTw" name="MassTransferBloodPool2OrgRBC" description="Mass transfer from ArterialBlood: BloodCells to organ: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="0KUbe9WbrUu3cwJdzrtioA" sourceAmount="gVpumttaHUG12bviSHchzw" targetAmount="1uMkucpciUqb_M1_slAxbg" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="Nyr3FSA25EW-jhEt1ttEdw" name="ArterialBlood_bc_Pancreas_bc" description="Neighborhood between Arterial Blood/Blood Cells and Pancreas/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="FtxmOVy3hEyMCuullB4l-A" secondNeighbor="i_uU7NwDCEeD0Ik1qMIqWA">
+                <Tags>
+                  <Tag value="Neighborhood: BloodCells / BloodCells" />
+                </Tags>
+                <Children>
+                  <Container id="_P6g_ctUwU-QwvddTba8Hw" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="SMf9ciWlNk-OZXQDJ1VT4w" name="MassTransferBloodPool2OrgRBC" description="Mass transfer from ArterialBlood: BloodCells to organ: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="Jk18-c-BGEaTrsr6MS905w" sourceAmount="gVpumttaHUG12bviSHchzw" targetAmount="_HDgRru2E06JCk8r7x3RxQ" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="EnmSCPmhaEaOew_kGtgD7A" name="ArterialBlood_bc_Skin_bc" description="Neighborhood between Arterial Blood/Blood Cells and Skin/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="FtxmOVy3hEyMCuullB4l-A" secondNeighbor="-ecrPvvqpkyCCZH2q8_isQ">
+                <Tags>
+                  <Tag value="Neighborhood: BloodCells / BloodCells" />
+                </Tags>
+                <Children>
+                  <Container id="sZ0--hML6k-py8CBrATG4A" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="HR3xEty-HUaFaWuaGhnS_Q" name="MassTransferBloodPool2OrgRBC" description="Mass transfer from ArterialBlood: BloodCells to organ: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="InKEGK2uOkCMgEuxjNsa3A" sourceAmount="gVpumttaHUG12bviSHchzw" targetAmount="oEugrKOiFU6poyyXxk4M5w" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="6xjY5CgKIkq-QMhP48AcHQ" name="ArterialBlood_bc_SmallIntestine_bc" description="Neighborhood between Arterial Blood/Blood Cells and Small Intestine/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="FtxmOVy3hEyMCuullB4l-A" secondNeighbor="Tg8zUU7tQUiyXi7TzpD9tA">
+                <Tags>
+                  <Tag value="Neighborhood: BloodCells / BloodCells" />
+                </Tags>
+                <Children>
+                  <Container id="xLwkRSk0M06-rvTqUdM1ow" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="l9G-s2SOjEGO1wYKwL4g3w" name="MassTransferBloodPool2OrgRBC" description="Mass transfer from ArterialBlood: BloodCells to organ: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="jm00ORa4pEiWaOaKe8FOWA" sourceAmount="gVpumttaHUG12bviSHchzw" targetAmount="40NocQSNtUSnzThV6rVJSA" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="BfJXWHn-l0-58qc-vpd55A" name="ArterialBlood_bc_Spleen_bc" description="Neighborhood between Arterial Blood/Blood Cells and Spleen/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="FtxmOVy3hEyMCuullB4l-A" secondNeighbor="A67vaaAIQk6PwZbW1swmtA">
+                <Tags>
+                  <Tag value="Neighborhood: BloodCells / BloodCells" />
+                </Tags>
+                <Children>
+                  <Container id="jXcWt3cohE-6pXDSoLyEuw" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="-w_BQixXN0OKWYEuW2wwxw" name="MassTransferBloodPool2OrgRBC" description="Mass transfer from ArterialBlood: BloodCells to organ: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="NOGRDQzpkEGsQj9qmhorMg" sourceAmount="gVpumttaHUG12bviSHchzw" targetAmount="t1oyMNylSECwz5JjP5KtSA" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="DUk70QKFbUS1dkKu2PuQJg" name="ArterialBlood_bc_Stomach_bc" description="Neighborhood between Arterial Blood/Blood Cells and Stomach/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="FtxmOVy3hEyMCuullB4l-A" secondNeighbor="S67OZB6elkOyyWZ-Fje_IQ">
+                <Tags>
+                  <Tag value="Neighborhood: BloodCells / BloodCells" />
+                </Tags>
+                <Children>
+                  <Container id="R_zStrw6Zkmv8k3NMLuosQ" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="aMdq2GDx4kS-ZSxoFWVdvQ" name="MassTransferBloodPool2OrgRBC" description="Mass transfer from ArterialBlood: BloodCells to organ: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="VhROc-iLCEyDS4B-JppjfA" sourceAmount="gVpumttaHUG12bviSHchzw" targetAmount="DYkNHTJFi06Z_FYe4PQWkw" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="QEywhUBlM06vtHeRZ6UI1Q" name="ArterialBlood_pls_Bone_pls" description="Neighborhood between Arterial Blood/Plasma and Bone/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="J4LFcXm4AkGl5yqJ_iZoPA" secondNeighbor="XIexKncboU6oimL2fajUaQ">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / Plasma" />
+                </Tags>
+                <Children>
+                  <Container id="MtPEHop4uUGucI2rqCIL9A" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="wKhSIHLDlEqQ348tqMaxOA" name="MassTransferBloodPool2OrgPl" description="Mass transfer from Arterial Blood: Plasma to organ: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="2MZlFTuTWUGvHxVYeLxywA" sourceAmount="Ms-OmcTJtEOdeIHT6btWvg" targetAmount="TGkDx4tZT0ypmP-gEA4AuA" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="Wglw0TGiJUShMoAysZ6sCw" name="ArterialBlood_pls_Brain_pls" description="Neighborhood between Arterial Blood/Plasma and Brain/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="J4LFcXm4AkGl5yqJ_iZoPA" secondNeighbor="6o29eHLmlky4_L3eSRa9CQ">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / Plasma" />
+                </Tags>
+                <Children>
+                  <Container id="rBM2zTPOsEydt_Tf_an3bw" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="SqTWLiSmo0qPge9I-BTmbw" name="MassTransferBloodPool2OrgPl" description="Mass transfer from Arterial Blood: Plasma to organ: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="gB52fEHXrU-WSw4buxaFmQ" sourceAmount="Ms-OmcTJtEOdeIHT6btWvg" targetAmount="QK7_wktim0CrMDuiwvhqLw" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="Oneqc4PSME-zkHYOfHpkAw" name="ArterialBlood_pls_Fat_pls" description="Neighborhood between Arterial Blood/Plasma and Fat/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="J4LFcXm4AkGl5yqJ_iZoPA" secondNeighbor="jJKX8FGI-UO3bnlzFyUdjw">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / Plasma" />
+                </Tags>
+                <Children>
+                  <Container id="_Q79sK-9Sk68fo9dq38clg" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="x2Yt0Wa7w0W-_iogUD5JoA" name="MassTransferBloodPool2OrgPl" description="Mass transfer from Arterial Blood: Plasma to organ: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="t4To_kkLHkO73qEFOCY3Gw" sourceAmount="Ms-OmcTJtEOdeIHT6btWvg" targetAmount="clnPhL5JykSeqIuCVtRsRg" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="7lDK009FmEmDpsXSqBLgoA" name="ArterialBlood_pls_Gonads_pls" description="Neighborhood between Arterial Blood/Plasma and Gonads/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="J4LFcXm4AkGl5yqJ_iZoPA" secondNeighbor="wol6uDYSXEC0_ZZPDrnoZQ">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / Plasma" />
+                </Tags>
+                <Children>
+                  <Container id="qx6-DY_Ey0KqcWCUSrKj8g" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="Tt2Bu8KqrkKiENSFeVr-hg" name="MassTransferBloodPool2OrgPl" description="Mass transfer from Arterial Blood: Plasma to organ: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="tvSsOLuBf0uAWahgOvn7Ig" sourceAmount="Ms-OmcTJtEOdeIHT6btWvg" targetAmount="mMcNFJzp6EuhC5J9Oc0mGg" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="oN88Q17OWEG3YDG3jUUcIw" name="ArterialBlood_pls_Heart_pls" description="Neighborhood between Arterial Blood/Plasma and Heart/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="J4LFcXm4AkGl5yqJ_iZoPA" secondNeighbor="Ql1dRMGROE-Xunwf1NB9cQ">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / Plasma" />
+                </Tags>
+                <Children>
+                  <Container id="5gloCClWq0CZ49CP40kj2g" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="iYDw-fRgj0iTNcDE1FiMMg" name="MassTransferBloodPool2OrgPl" description="Mass transfer from Arterial Blood: Plasma to organ: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="UIn2znbS9UGsRN1lFNbfZA" sourceAmount="Ms-OmcTJtEOdeIHT6btWvg" targetAmount="XyRpEuOb2kq1o-aKqGsssw" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="6zLnqbBmbkO2wTnOp7159A" name="ArterialBlood_pls_Kidney_pls" description="Neighborhood between Arterial Blood/Plasma and Kidney/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="J4LFcXm4AkGl5yqJ_iZoPA" secondNeighbor="5HBO78nMlkKNzLDJB1gD3w">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / Plasma" />
+                </Tags>
+                <Children>
+                  <Container id="_fd7eu3SmEuxWoytShcY7A" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="HmOZSCZvtECZkFj3jRvjWw" name="MassTransferBloodPool2OrgPl" description="Mass transfer from Arterial Blood: Plasma to organ: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="UdVn52UAs0OtQFUZ7oKMwg" sourceAmount="Ms-OmcTJtEOdeIHT6btWvg" targetAmount="UIDahFhwD0qylCjxxmdl8g" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="jLU9wXmEF0yt4Pw7N0GTnA" name="ArterialBlood_pls_LargeIntestine_pls" description="Neighborhood between Arterial Blood/Plasma and Large Intestine/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="J4LFcXm4AkGl5yqJ_iZoPA" secondNeighbor="ktOYgOHeEU6lrdTGt7nwtw">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / Plasma" />
+                </Tags>
+                <Children>
+                  <Container id="d_s3QX8s7Uu4nDqSq8XljA" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="kcdSWqum8UCwi-450050Og" name="MassTransferBloodPool2OrgPl" description="Mass transfer from Arterial Blood: Plasma to organ: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="eK11lIlJz0KfxIlF8i08LQ" sourceAmount="Ms-OmcTJtEOdeIHT6btWvg" targetAmount="egltpUZO6EWeO7Pbo85uvA" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="5szfDCRlsk2g9e7MrtpNMw" name="ArterialBlood_pls_Muscle_pls" description="Neighborhood between Arterial Blood/Plasma and Muscle/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="J4LFcXm4AkGl5yqJ_iZoPA" secondNeighbor="QuubSGLj2kWxXZwVnyWwJA">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / Plasma" />
+                </Tags>
+                <Children>
+                  <Container id="-N-C5p4it0yy7bILQ7dZ_g" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="AMEgmLia5kuqRHnl2p1f7g" name="MassTransferBloodPool2OrgPl" description="Mass transfer from Arterial Blood: Plasma to organ: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="LeohaAN4jkuYSZBBtqVOKw" sourceAmount="Ms-OmcTJtEOdeIHT6btWvg" targetAmount="bO7yYOOyBEiA8uil4vPbiw" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="6botO__ZMUqd_H9qYYGeIA" name="ArterialBlood_pls_Pancreas_pls" description="Neighborhood between Arterial Blood/Plasma and Pancreas/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="J4LFcXm4AkGl5yqJ_iZoPA" secondNeighbor="5C6Dv04n9EGG4vtDsR-UpQ">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / Plasma" />
+                </Tags>
+                <Children>
+                  <Container id="RD5Fb1PRPUmKsG1CAQdJxg" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="hoRemRtJMEmBMlZBDhsAhA" name="MassTransferBloodPool2OrgPl" description="Mass transfer from Arterial Blood: Plasma to organ: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="37C2GuMI_EaI4PAgBe5XHA" sourceAmount="Ms-OmcTJtEOdeIHT6btWvg" targetAmount="AdODwmUjQk69oFXjb-S1SA" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="8N1flDPpjkO2Iei52hGrow" name="ArterialBlood_pls_Skin_pls" description="Neighborhood between Arterial Blood/Plasma and Skin/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="J4LFcXm4AkGl5yqJ_iZoPA" secondNeighbor="eTnjoGpclkKg5pWP1EfS6g">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / Plasma" />
+                </Tags>
+                <Children>
+                  <Container id="Z9z9EoRrvEG4L5flhtatgw" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="ye0mvBvPZky9UJG3Hjc0KA" name="MassTransferBloodPool2OrgPl" description="Mass transfer from Arterial Blood: Plasma to organ: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="SGTYuIKKR0m47MyCftZcBQ" sourceAmount="Ms-OmcTJtEOdeIHT6btWvg" targetAmount="-L3poskufEiY_yLCZj9nlg" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="cXlXIAMsuUqbfSxwEDB3HA" name="ArterialBlood_pls_SmallIntestine_pls" description="Neighborhood between Arterial Blood/Plasma and Small Intestine/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="J4LFcXm4AkGl5yqJ_iZoPA" secondNeighbor="Fy6Itf9MIUGQAeAvyt7KGg">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / Plasma" />
+                </Tags>
+                <Children>
+                  <Container id="HGtbzw6phUqfqW1j5JQGWg" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="VeIRd9Gq8kKg9BgRqrkcWg" name="MassTransferBloodPool2OrgPl" description="Mass transfer from Arterial Blood: Plasma to organ: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="acDGl2NY-EOLijj_t6RwBA" sourceAmount="Ms-OmcTJtEOdeIHT6btWvg" targetAmount="WaDZEuqgsEyV_ckNljlU_g" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="_CoHl0Ye_EiQtYjES9WvGw" name="ArterialBlood_pls_Spleen_pls" description="Neighborhood between Arterial Blood/Plasma and Spleen/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="J4LFcXm4AkGl5yqJ_iZoPA" secondNeighbor="DtIYfXogNkW8hZs4wYJNHQ">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / Plasma" />
+                </Tags>
+                <Children>
+                  <Container id="0mQFY0nRak6XjVk4Wb89TQ" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="3ImSs63Q0U2lXP3lgJpOZg" name="MassTransferBloodPool2OrgPl" description="Mass transfer from Arterial Blood: Plasma to organ: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="oZY6gr5IAEaY5DJ6GYo-5A" sourceAmount="Ms-OmcTJtEOdeIHT6btWvg" targetAmount="Gtf9_5p6HUOjDhTB24z5BA" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="0iJJ9mHuPk6OZiGNTh5VzA" name="ArterialBlood_pls_Stomach_pls" description="Neighborhood between Arterial Blood/Plasma and Stomach/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="J4LFcXm4AkGl5yqJ_iZoPA" secondNeighbor="XcgWz7kj0EeW4Lgi_bRWBg">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / Plasma" />
+                </Tags>
+                <Children>
+                  <Container id="BbQ88VE1uU-kzH8b9XnDmA" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="F4vAUrF5-U6DgUoe5KX6hQ" name="MassTransferBloodPool2OrgPl" description="Mass transfer from Arterial Blood: Plasma to organ: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="qA9uw2U8HkeTTZMRtyXQ0Q" sourceAmount="Ms-OmcTJtEOdeIHT6btWvg" targetAmount="OtZkUmx1dESechCvzFNp-w" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="Qqvkcvp-yky7ujlOdc62hQ" name="Lumen_duo_Duodenum_pls" description="Neighborhood between Lumen/Duodenum and Mucosa/Duodenum/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="FiXHspIznEeQWrX1VkMsyg" secondNeighbor="XAgCyFXUeEiKySGRkrx1lw">
+                <Tags>
+                  <Tag value="Neighborhood: Duodenum / Plasma" />
+                </Tags>
+                <Children>
+                  <Container id="QwNnc0pR10SS6u2jXOtP0g" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="ufpeqp-DV0SKCmU08L7HwA" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="s7iIvXiKPU-6tMdXGBBWrg" isDefault="1" displayUnit="µmol/min">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                      </Parameter>
+                      <Parameter id="RNhjjmMWo0680NGUkB3mLQ" name="Sum of active process rates" description="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="uyCWbLwgAEyo2Ve6JsEKYg" isDefault="1" displayUnit="µmol/min">
+                        <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="j9GlhE7ulUGpHjKGz0JU0g" name="Sum of passive process rates" description="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="rgSQzZXCIkSOVgf3T6khWw" isDefault="1" displayUnit="µmol/min">
+                        <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Transport id="sZeVa28Xf06QIZAEajyQbA" name="DrugAbsorption_para" description="Drug absorption paracellular" mode="Logical" containerType="Transport" dimension="Amount per time" formula="1kKq4syDR0WxssFW3P5Arg" sourceAmount="QIs0jmUAIE6ikShycjAOCw" targetAmount="6jMviBffOESTP5M0G7YuJg">
+                        <Children>
+                          <Parameter id="Hsm1bY-B0k6OXWDLZXpa3g" name="ProcessRate" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="jzqKDyRsmU68VJFXF08Epg" isDefault="1" displayUnit="µmol/min">
+                            <Tags>
+                              <Tag value="DrugAbsorption_para" />
+                              <Tag value="ProcessRate" />
+                              <Tag value="Aciclovir" />
+                              <Tag value="Lumen_duo_Duodenum_pls" />
+                              <Tag value="Passive" />
+                            </Tags>
+                            <Info flag="6" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                        </Children>
+                      </Transport>
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="SkY8liyjfkWpJeF15BAIDA" name="Lumen_duo_Duodenum_cell" description="Neighborhood between Lumen/Duodenum and Mucosa/Duodenum/Intracellular" mode="Logical" containerType="Neighborhood" firstNeighbor="FiXHspIznEeQWrX1VkMsyg" secondNeighbor="Aj167RPpD0WYC-nZy2suGA">
+                <Tags>
+                  <Tag value="Neighborhood: Duodenum / Intracellular" />
+                </Tags>
+                <Children>
+                  <Container id="JHIrjR5IHECa41fPrZFFmA" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="nRhjAuzV30-dk3P855b-mQ" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="k9ShH-8xQkCkqZfxi6BXNg" isDefault="1" displayUnit="µmol/min">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                      </Parameter>
+                      <Parameter id="AgUFur3nQEGtVMvTyoyx9g" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="3y6-m8wgOEKD3GtEjz0zzg" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="9pcZkSCO-kWHqMNPztprwQ" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="lJ91Y9prMU-IAOmp8VeUZA" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="gmlcyZKVwUC5xwtKjw26QQ" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="9psOYAn0NkGyn7igwQNVTg" isDefault="1">
+                        <Info min="0" flag="36" seq="1" ref="0" bb="2" group="67" />
+                      </Parameter>
+                      <Parameter id="0emIDoVKvUSkuMNAFb-ULQ" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="bZ2dDR_soEuRo7NhGX-G3A" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+                      </Parameter>
+                      <Parameter id="kvwLRYGDhE6ACtPTXzkdwA" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="K_6EDWu3Tkm_ep44s1Fblg" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="5elTCstNek-euooLnw0PoA" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="rskHfYRsSEe7JIenQStQEg" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="Uc6q2ln0aU-6y5RQJu842Q" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="o_gKGJceeUO4KvWn64T__g" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="m3GkVxMijkqXuul5fndG3g" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="lfuixO3kjEW_DgVwm-NEkA" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="EBZDuh00FUCNN6KmlYHb3Q" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="wpZOWtsCVEivIawZ0cJTQQ" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="1lFsffZmZUW9mTOtPCaS-w" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="zDjvv8qD_0q6sFClKz_6Dw" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="QrxNOvJf8USa3GqAfO49Nw" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IIYsrx_Fhkm3HVhCSgi4JA" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="tJhPkpQ370-G7x9xpHFLBw" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="unqtYV5AeEOgOCuJHP2VSA" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="1HJhUM8o0EmWnXYPd8RG3Q" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="bpZDuWciwU2LDzUNVjrx2A" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="Y4mKajR9Dk-MObx8uEhLmg" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="WlVW33RvI0izDWhDdH2ACw" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="6VoRlRvUMEWPrBbGGGLZVw" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="lZaz3UUV6EeQOunL9WZ4_g" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="aBGpkTJda0iZm8qfAK3FNw" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="rv0ZQKGwfU6pTM0wm__jGw" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="Aci5T7VS_UCvUkM7Ng5Gog" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="bSiN7sUxgE6zdtQZq4J2OQ" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="uK-QGGnqC0GZHn_MUZW6SQ" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="5bm96plKu0W6FHo2mAd9ww" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="TaHZ-rjMY027BoKXyd2r1A" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="5JG_BBjIek6qnerxqqbp5A" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="Rsz_fGZKbkmRrsFL6wLWhA" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="9Avqn_lfmkOYWTl8-_rMmg" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="I4WAHMBKXkmgcfW58OzvMQ" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ucHi0vXPN0WPpok-4cCWCQ" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="hDFxWODhPEC3LFkDwltx3Q" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Q7JAceEGmkCCiLcIdSgVFg" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="-lfGiidk4U2qYUG-t85CaA" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cg3-HM5rEkyKAe6nt4Tgnw" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="mvrygERK-kyE87Vonhddpw" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="rI_XOwPh-kSUkyS48tdLCw" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="1yN3XTfZNEOcXwbCvbSeEQ" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="2MsqcDgQ9kWp8tSdr6OMJQ" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="pZxZt30wBEeDKAnZ1Dc04g" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="fRQlUllt4kGqcKWlmlGP7g" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="CYpoVVuhJE6Xdu5Rduv6NQ" name="Sum of active process rates" description="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="LGcxvFDjYUKqdHAkPagqyg" isDefault="1" displayUnit="µmol/min">
+                        <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="8Q92ryqx0EGd5S6F93_iqQ" name="Sum of passive process rates" description="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="VcjnWMIWj0mUWBe59LosCQ" isDefault="1" displayUnit="µmol/min">
+                        <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Transport id="nGbTxWngs02XySKhfyNl_g" name="DrugAbsorption_trans" description="Drug absorption transcellular" mode="Logical" containerType="Transport" dimension="Amount per time" formula="uZ8X4Hv8hEeHY35aRmqErw" sourceAmount="QIs0jmUAIE6ikShycjAOCw" targetAmount="WZvp19tK5EuOI6FlH_xZ0g">
+                        <Children>
+                          <Parameter id="nFQAECshq0uLmOsZNv8SNw" name="ProcessRate" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="wQqp6XIYyUKy1tXL91opNw" isDefault="1" displayUnit="µmol/min">
+                            <Tags>
+                              <Tag value="DrugAbsorption_trans" />
+                              <Tag value="ProcessRate" />
+                              <Tag value="Aciclovir" />
+                              <Tag value="Lumen_duo_Duodenum_cell" />
+                              <Tag value="Passive" />
+                            </Tags>
+                            <Info flag="6" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                        </Children>
+                      </Transport>
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="lTJI0YEdn0it4EoMCyItAA" name="Duodenum_pls_PortalVein_pls" description="Neighborhood between Duodenum/Plasma and PortalVein/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="XAgCyFXUeEiKySGRkrx1lw" secondNeighbor="s_QiQGLN10Omt7YLmTFwjg">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / Plasma" />
+                </Tags>
+                <Children>
+                  <Container id="Qqfk-xTdWU-M-O-FYZQ3wA" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="47-Yo4jRdUGDHscjWWt-WQ" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="6mILFwNC-EC5G8qQYgRV7A" isDefault="1" displayUnit="µmol/min">
+                        <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                      </Parameter>
+                      <Transport id="cQ-y_nN9J0Wa5W7gLihJlw" name="MassTransferMucosaToPvePlasma" description="Mass transfer from Mucosa:Plasma To Portal Vein: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="PX17T8c50Uexhv9RYjqxBg" sourceAmount="6jMviBffOESTP5M0G7YuJg" targetAmount="JvJXBdwv-UOGE6DoopBJuA" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="FEAEuwClvky6Ce0pjD2nTw" name="Duodenum_bc_PortalVein_bc" description="Neighborhood between Duodenum/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="YoUcbCdrsUy6MzLzw16fQA" secondNeighbor="-iUsllv1MkOvPkSoihwHiA">
+                <Tags>
+                  <Tag value="Neighborhood: BloodCells / BloodCells" />
+                </Tags>
+                <Children>
+                  <Container id="WSySfvMFlEmWHO48Vpj_FA" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="rkVu-N4US0KMq_ItxHodQA" name="Mass transfer rate (mucosa to portal vein blood cells)" description="Mass transfer rate (mucosa to portal vein blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="504OYOKeC0aKpiuytfzWAA" isDefault="1" displayUnit="µmol/min">
+                        <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                      </Parameter>
+                      <Transport id="wPuxLTG7IEO91NLsSGDadg" name="MassTransferMucosaToPveBC" description="Mass transfer from Mucosa:Blood Cells To Portal Vein: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="jJauYu-JNk2kPtCVvieJow" sourceAmount="NSDFFYYE00y77UxrZNLCtQ" targetAmount="RCAqJaBNgE-vkuaKfPZpnw" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="oGaZKjuXoEWsxGt92PfiQA" name="Lumen_cae_Caecum_pls" description="Neighborhood between Lumen/Cecum and Mucosa/Cecum/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="uYzhyHESRE2AJZ8aM48hjw" secondNeighbor="mJ1VEhL0vEWlFO5jRJmtfA">
+                <Tags>
+                  <Tag value="Neighborhood: Caecum / Plasma" />
+                </Tags>
+                <Children>
+                  <Container id="oupv5wVJLEGzGn9Bjeek1w" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="U8EPZDEwkkyRmiZ9Anv8LA" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="PNkrAkHRe0iZlA-g-7dOdw" isDefault="1" displayUnit="µmol/min">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                      </Parameter>
+                      <Parameter id="G7diBTA4GkSqkYHdHcrMpw" name="Sum of active process rates" description="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="RDuoYLazgUGPH6JauNyrGQ" isDefault="1" displayUnit="µmol/min">
+                        <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="abJAeEKMuke9oGzXU1Aklg" name="Sum of passive process rates" description="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Zo3b5lc1y0u8APo69N9t2g" isDefault="1" displayUnit="µmol/min">
+                        <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="8fz7wlSUlkmqI2XvwiQX8g" name="Lumen_cae_Caecum_cell" description="Neighborhood between Lumen/Cecum and Mucosa/Cecum/Intracellular" mode="Logical" containerType="Neighborhood" firstNeighbor="uYzhyHESRE2AJZ8aM48hjw" secondNeighbor="AKVKQTBp2USrIEs1XsdgtQ">
+                <Tags>
+                  <Tag value="Neighborhood: Caecum / Intracellular" />
+                </Tags>
+                <Children>
+                  <Container id="mgWpwQTfr0mveNj4vZBMyw" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="YErtNR2StUS9ACzAsp3sxA" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="iv2tVw7wI0mf3_L5TnsauQ" isDefault="1" displayUnit="µmol/min">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                      </Parameter>
+                      <Parameter id="ai-s4GbGHkip02f0sXE-Ug" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="3y6-m8wgOEKD3GtEjz0zzg" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="W3184ygdpka9B5e5hjBf4Q" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="lJ91Y9prMU-IAOmp8VeUZA" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="hnyUTqJlpkW1LkUQaMWyFQ" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="qCOSWHeB1Uy9zxKxZqw4cg" isDefault="1">
+                        <Info min="0" flag="36" seq="1" ref="0" bb="2" group="67" />
+                      </Parameter>
+                      <Parameter id="KSeQgTokdkySKI7ldKTBiA" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="tWTVmAKN2UGv5AI4Tnv1EQ" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+                      </Parameter>
+                      <Parameter id="sI4snWWhmk-j5ZykxBukUw" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Xyn2COyJl0ySoDgh3hxJ6g" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="wjr6VH2nyk-7KCcepKmmsQ" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="RxCK652vP0OA9ANEMAy7mg" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="HE8oBnPpS02LKGSAJz1GnQ" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="A0Y4MkmkYE2qQbNo4eD1QQ" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="psKqGO8drEuBa7yiJ5WlcA" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="lfuixO3kjEW_DgVwm-NEkA" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="SoEyLPPRJ0Oid0TUG2pWnw" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="wpZOWtsCVEivIawZ0cJTQQ" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="SsWl9UsSJ0ielg3ttwa7aA" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="zDjvv8qD_0q6sFClKz_6Dw" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="isCW-YGyOkqXlvrt1SKfgQ" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IIYsrx_Fhkm3HVhCSgi4JA" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="4JO0gQaFNk68vfRAAK2BAg" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="unqtYV5AeEOgOCuJHP2VSA" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="kEqYgmBEj0iBTnFowZfRrg" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="bpZDuWciwU2LDzUNVjrx2A" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="UWkv9dzBNEyAjzXDT8q1MA" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="WlVW33RvI0izDWhDdH2ACw" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="hub9fmO_mk-giXlJoSkJUg" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="lZaz3UUV6EeQOunL9WZ4_g" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="Bp4zIritAECYh-sVY1MouA" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="2IDFEWB6BkaPSpUynAo5gA" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="TG1NlpjOGUubvDekwDGPpg" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="uEAxca-XsECmh3RGxW5y1Q" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="n0spMnkDz02oH1B3N51FPg" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="58ANSoAXLka9lTnUc32p8g" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="u4laQReVHU2-FoAt_Ys-uw" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="5JG_BBjIek6qnerxqqbp5A" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="k9oz58q3jkiTqzNlFzcBEw" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="9Avqn_lfmkOYWTl8-_rMmg" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="2ek-V0oUDUu9qzjZ9OZzHw" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ucHi0vXPN0WPpok-4cCWCQ" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="jpflyLprhEmmqDi7n8UMcg" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Q7JAceEGmkCCiLcIdSgVFg" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="DkFjygpTK0mKp-PMxSYKPg" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cg3-HM5rEkyKAe6nt4Tgnw" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="ynGApjIWCEmdSlr3HqsW8w" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="rI_XOwPh-kSUkyS48tdLCw" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="13fq1PiIOk25C7N7iHQ7Ww" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="2MsqcDgQ9kWp8tSdr6OMJQ" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="ozgBZGxzQ0qEK5Cc53yjvg" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="fRQlUllt4kGqcKWlmlGP7g" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="3gYsBASkEUCYZxA1WGhSsQ" name="Sum of active process rates" description="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="r492s3ML4kyMUzr8_4keBw" isDefault="1" displayUnit="µmol/min">
+                        <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="tbnmW87vCkS2d6jFXkcvIQ" name="Sum of passive process rates" description="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="IQsG6gOWQ0abbAjkVphO4Q" isDefault="1" displayUnit="µmol/min">
+                        <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Transport id="LgidY18ob0CHKBn62uJ5Ag" name="DrugAbsorption_trans" description="Drug absorption transcellular" mode="Logical" containerType="Transport" dimension="Amount per time" formula="tnCa2VmhlEmDKn9MxvKWfA" sourceAmount="bl-WKAeEGkqp-gMj0y8wBQ" targetAmount="_mNlhygPYk6in-N0aLpi3w">
+                        <Children>
+                          <Parameter id="35xmy_rBxk2R5tIzt2WxLg" name="ProcessRate" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="_l8oPX5ijkG3B69VSY0PTg" isDefault="1" displayUnit="µmol/min">
+                            <Tags>
+                              <Tag value="DrugAbsorption_trans" />
+                              <Tag value="ProcessRate" />
+                              <Tag value="Aciclovir" />
+                              <Tag value="Lumen_cae_Caecum_cell" />
+                              <Tag value="Passive" />
+                            </Tags>
+                            <Info flag="6" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                        </Children>
+                      </Transport>
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="mgSGBajahEeL-wyCZ534FA" name="Caecum_pls_PortalVein_pls" description="Neighborhood between Cecum/Plasma and PortalVein/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="mJ1VEhL0vEWlFO5jRJmtfA" secondNeighbor="s_QiQGLN10Omt7YLmTFwjg">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / Plasma" />
+                </Tags>
+                <Children>
+                  <Container id="zsLG4u5P70eywQYtYLHYiQ" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="tkm0sDHVL027wcdz-1cO9g" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="eGUjNyh4y0K9zKELnt4TLQ" isDefault="1" displayUnit="µmol/min">
+                        <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                      </Parameter>
+                      <Transport id="zNwSu71JUE2N3JwDQUf0Dg" name="MassTransferMucosaToPvePlasma" description="Mass transfer from Mucosa:Plasma To Portal Vein: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="yobZj8g8PUu9z44sWwil6Q" sourceAmount="wao9GN6hn0eOf7hZ3UZj9w" targetAmount="JvJXBdwv-UOGE6DoopBJuA" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="wt1tY0G-JUyvEvvTISEFog" name="Caecum_bc_PortalVein_bc" description="Neighborhood between Cecum/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="0JvhwzGCx02WPt8g_nY3lg" secondNeighbor="-iUsllv1MkOvPkSoihwHiA">
+                <Tags>
+                  <Tag value="Neighborhood: BloodCells / BloodCells" />
+                </Tags>
+                <Children>
+                  <Container id="QDbmRwjh6keKsSkl6Kcvmg" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="ekem2h5cZ0afwyOqrbdl5g" name="Mass transfer rate (mucosa to portal vein blood cells)" description="Mass transfer rate (mucosa to portal vein blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="63K45AUlBUefQHJ7AdtEXA" isDefault="1" displayUnit="µmol/min">
+                        <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                      </Parameter>
+                      <Transport id="F7aetO_L0USFv1sqZaS9ug" name="MassTransferMucosaToPveBC" description="Mass transfer from Mucosa:Blood Cells To Portal Vein: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="kf0i5Kt8XEit3sV2pb-aoQ" sourceAmount="o6NCkHAV3ECgxc8vuMn83w" targetAmount="RCAqJaBNgE-vkuaKfPZpnw" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="YttyXWqYB0iKCO_LXPpzTA" name="Lumen_colasc_ColonAscendens_pls" description="Neighborhood between Lumen/Colon Ascendens and Mucosa/Colon Ascendens/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="tkfxCJO3sk6qgcu2TdYoFQ" secondNeighbor="3IX6ZvrqBE2RAum9H4_lpw">
+                <Tags>
+                  <Tag value="Neighborhood: ColonAscendens / Plasma" />
+                </Tags>
+                <Children>
+                  <Container id="wUZCns1JFUC_B4d2UUcuYg" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="1n58wQwdw0KqqHtlTZd8vw" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="dU6nzA0nwEm7boOB0bzX3Q" isDefault="1" displayUnit="µmol/min">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                      </Parameter>
+                      <Parameter id="K7B2YRGf6EWyGTv-mLwHRg" name="Sum of active process rates" description="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="psOX5SwkzE-IihkHrRr1Bg" isDefault="1" displayUnit="µmol/min">
+                        <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="0zNFy-GSkUmmJhxaXKT9MQ" name="Sum of passive process rates" description="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="gBeysljVd0GEJJrumZr2_Q" isDefault="1" displayUnit="µmol/min">
+                        <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="kObortLaFEGUtGFm4Ekc4w" name="Lumen_colasc_ColonAscendens_cell" description="Neighborhood between Lumen/Colon Ascendens and Mucosa/Colon Ascendens/Intracellular" mode="Logical" containerType="Neighborhood" firstNeighbor="tkfxCJO3sk6qgcu2TdYoFQ" secondNeighbor="6GTdN--hKEqMH9mEmfYH6A">
+                <Tags>
+                  <Tag value="Neighborhood: ColonAscendens / Intracellular" />
+                </Tags>
+                <Children>
+                  <Container id="40RzTsExIkW2nGGskzdYbw" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="fqaQ2ZsmykaE78hsQEeOVg" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="q_-c_6xgy0OeEqsyokn2vg" isDefault="1" displayUnit="µmol/min">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                      </Parameter>
+                      <Parameter id="Z3GKL-sNo0mfY5PKGGsEUw" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="3y6-m8wgOEKD3GtEjz0zzg" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="JBUcy17wHkWEWY_mLDPQ2g" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="lJ91Y9prMU-IAOmp8VeUZA" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="1p1gLL6Ygkqt43WNO9jq1g" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DVj9pdj8CEKCmpx5rdTIzQ" isDefault="1">
+                        <Info min="0" flag="36" seq="1" ref="0" bb="2" group="67" />
+                      </Parameter>
+                      <Parameter id="z78s7CBwUU6BlKODd6FI1A" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="XMZnl1vxIUKN6zEsBOcqrw" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+                      </Parameter>
+                      <Parameter id="D2NZqAc_tEeqnliT9mY6IA" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="lXnv1KVwREmXLbmWgk3zEg" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="Ze5pWVmzS0abcUqfAH8JWw" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Dv32X50fYEmBtoC-qyOV7A" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="lQQIl_uKPkeqHMhtoNmcxw" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="kexB5UcFEEyucrY-UIUKaQ" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="7TFH6O6Qq02xjNJ9c8sEAw" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="lfuixO3kjEW_DgVwm-NEkA" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="pc45LiDHLUOkkwQYWDMHWg" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="wpZOWtsCVEivIawZ0cJTQQ" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="wfZ557OGekamEsIHlbkwbg" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="zDjvv8qD_0q6sFClKz_6Dw" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="EYdQ_9K3FEqDchnrQmsM0w" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IIYsrx_Fhkm3HVhCSgi4JA" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="5WQkev8p0k6CJG1kKSfA1A" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="unqtYV5AeEOgOCuJHP2VSA" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="xitedz5uNUGbrBQ58dBDyA" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="bpZDuWciwU2LDzUNVjrx2A" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="fmXbmzkuak-XfOGhAVWuLg" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="WlVW33RvI0izDWhDdH2ACw" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="l3SaBMxUKUmxobPR-TNzVw" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="lZaz3UUV6EeQOunL9WZ4_g" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="M5Y6VvCZ2EyfiMWCet_g1A" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="K1LacTijvU-qTagAxtD6cw" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="HV9IC2nqoU-ZoD-8tpAM8w" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ZgjSWE4bLU2Uf31SL3xeSw" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="X2mxWDkB5UmyHcQCK_zLzw" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="2Oz1g1U_UkyIpODWAkvO-g" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="6GeNyjN8K0uC8RYR2nJfOw" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="5JG_BBjIek6qnerxqqbp5A" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="a3MX3j6LXEiUs_0YDf1oDw" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="9Avqn_lfmkOYWTl8-_rMmg" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="5TvZm095Pk697N_NqEcWfg" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ucHi0vXPN0WPpok-4cCWCQ" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="Ze2APxpMhECPB7M7UtuujA" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Q7JAceEGmkCCiLcIdSgVFg" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="pcvQJXmOiUq10u7H0geswA" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cg3-HM5rEkyKAe6nt4Tgnw" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="qI0WrHetyk-Yi_-vsCiZhw" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="rI_XOwPh-kSUkyS48tdLCw" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="SLb3Qiap30y3PFyrZC0vZQ" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="2MsqcDgQ9kWp8tSdr6OMJQ" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="gbrjI2L4eU-54zoz9Zdkxw" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="fRQlUllt4kGqcKWlmlGP7g" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="VXutSOR6DEKDNZFeotTvjw" name="Sum of active process rates" description="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="k5vtOyYP4EqjMCrHn3HCaQ" isDefault="1" displayUnit="µmol/min">
+                        <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="8cZ-ryQGBEq4GcKgYwscGg" name="Sum of passive process rates" description="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="tHrTJm0LgESSDYnj62L25Q" isDefault="1" displayUnit="µmol/min">
+                        <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Transport id="bfiqZSQJBUeMuD2elngMTA" name="DrugAbsorption_trans" description="Drug absorption transcellular" mode="Logical" containerType="Transport" dimension="Amount per time" formula="QkHTCemItUmrN7rPhRxijw" sourceAmount="JpU_43QuWEeLn_RwxMDZeA" targetAmount="KpXMMvTcfEGpXan02OjF7g">
+                        <Children>
+                          <Parameter id="h9JQgkib-Eqa3qVLP791mw" name="ProcessRate" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="4FMq1Ke1vkWIBTxWFyXCbg" isDefault="1" displayUnit="µmol/min">
+                            <Tags>
+                              <Tag value="DrugAbsorption_trans" />
+                              <Tag value="ProcessRate" />
+                              <Tag value="Aciclovir" />
+                              <Tag value="Lumen_colasc_ColonAscendens_cell" />
+                              <Tag value="Passive" />
+                            </Tags>
+                            <Info flag="6" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                        </Children>
+                      </Transport>
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="ExUL9sT7qEWRyMK0o3AI5A" name="ColonAscendens_pls_PortalVein_pls" description="Neighborhood between Colon Ascendens/Plasma and PortalVein/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="3IX6ZvrqBE2RAum9H4_lpw" secondNeighbor="s_QiQGLN10Omt7YLmTFwjg">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / Plasma" />
+                </Tags>
+                <Children>
+                  <Container id="YAgFFhjaoUaqRObTfHKkyA" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="ka-EcsDZ2EeEIuCZa-56bg" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="scFvx-FXXEWIv-TeH4OZRA" isDefault="1" displayUnit="µmol/min">
+                        <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                      </Parameter>
+                      <Transport id="vPVBSqifGECxYiCXf7TA7w" name="MassTransferMucosaToPvePlasma" description="Mass transfer from Mucosa:Plasma To Portal Vein: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="JK1JTi9EBEK6TShDmuySiw" sourceAmount="gdVc1LkaqUKWwNPeWpWNFA" targetAmount="JvJXBdwv-UOGE6DoopBJuA" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="40ux_z1CYkK80jOKidkOFw" name="ColonAscendens_bc_PortalVein_bc" description="Neighborhood between Colon Ascendens/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="fY5-Tz2cDk-SgbOQbDDDkQ" secondNeighbor="-iUsllv1MkOvPkSoihwHiA">
+                <Tags>
+                  <Tag value="Neighborhood: BloodCells / BloodCells" />
+                </Tags>
+                <Children>
+                  <Container id="OGo6Bv7R_E6dRigIIKt9zw" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="5fbmF-JOB0-ZBfAOgzvObw" name="Mass transfer rate (mucosa to portal vein blood cells)" description="Mass transfer rate (mucosa to portal vein blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="DPShSeBPIUGydVQTlD2apA" isDefault="1" displayUnit="µmol/min">
+                        <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                      </Parameter>
+                      <Transport id="F1h4ajzpdE2sPH9nHSvRpQ" name="MassTransferMucosaToPveBC" description="Mass transfer from Mucosa:Blood Cells To Portal Vein: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="cnogIwXX00qOUhadbSNGmQ" sourceAmount="wSMMb12yZkCZl46czAda2g" targetAmount="RCAqJaBNgE-vkuaKfPZpnw" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="Fms3zCrG10Cp4ofAOedm7w" name="Lumen_coltrans_ColonTransversum_pls" description="Neighborhood between Lumen/Colon Transversum and Mucosa/Colon Transversum/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="lYdNatoo8k6R4a61MnSWxw" secondNeighbor="VsgWfVKXeUyOdIOdNnIPwA">
+                <Tags>
+                  <Tag value="Neighborhood: ColonTransversum / Plasma" />
+                </Tags>
+                <Children>
+                  <Container id="x5sOu4MX70yQusY7QAU-NQ" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="uK5viwiguEaaHbseGoG0ug" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="aXEV6lIffU6qw7kL5VDg_g" isDefault="1" displayUnit="µmol/min">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                      </Parameter>
+                      <Parameter id="DA6MdjaTXE29ZrBmUn4GZg" name="Sum of active process rates" description="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="al_CxtpU4UyE4LWJXA7GXQ" isDefault="1" displayUnit="µmol/min">
+                        <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="V6lk5Cpf1USo8hILEEesbQ" name="Sum of passive process rates" description="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="rdKilAcf1UOj32MNIarZ1w" isDefault="1" displayUnit="µmol/min">
+                        <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="yD-_SEUozEi7e0P0QnIs7w" name="Lumen_coltrans_ColonTransversum_cell" description="Neighborhood between Lumen/Colon Transversum and Mucosa/Colon Transversum/Intracellular" mode="Logical" containerType="Neighborhood" firstNeighbor="lYdNatoo8k6R4a61MnSWxw" secondNeighbor="K_DTJO3kn0WFG-dPb6WJzw">
+                <Tags>
+                  <Tag value="Neighborhood: ColonTransversum / Intracellular" />
+                </Tags>
+                <Children>
+                  <Container id="biitvnLi_0yCVoGVvsy7PQ" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="s5_5GMXFc0-jWAFRHMWyjA" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="QtwGZFIRh0a4YuukbcrA3Q" isDefault="1" displayUnit="µmol/min">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                      </Parameter>
+                      <Parameter id="ovOAfBW0c0KcScoPtc732A" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="3y6-m8wgOEKD3GtEjz0zzg" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="iK_rp9KREUaMaJsa8rTpFA" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="lJ91Y9prMU-IAOmp8VeUZA" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="Av-Z56yTxkC0UIDziuepJA" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="sVq1Emo1akinSJoCw-rNDQ" isDefault="1">
+                        <Info min="0" flag="36" seq="1" ref="0" bb="2" group="67" />
+                      </Parameter>
+                      <Parameter id="yzt9RvxrQEWmd_kIX9dV1Q" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="rx71x0GRK0WYYGPFPdekNg" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+                      </Parameter>
+                      <Parameter id="bWFTmdWRcUSj1Wd9LO8v-Q" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="OXYzrrcaDk-PVnrOIr7VWA" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="yKM4vHVfjUClfqNen31E_A" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="p94DwfgUk0u18VHcngyDSw" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="DYbWDxCJrUaG3FeGqpz33w" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="OIYONuAZTEmsD66qV1_bWg" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="NgdQlUTSkUSNfCXKAELojA" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="lfuixO3kjEW_DgVwm-NEkA" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="iwJw8AVOoUSuBuCshTPV_Q" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="wpZOWtsCVEivIawZ0cJTQQ" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="bPd9fHa9c0y58nYFlWm_ew" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="zDjvv8qD_0q6sFClKz_6Dw" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="f7oej1TneUqMKBOUwPA20g" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IIYsrx_Fhkm3HVhCSgi4JA" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="lvMq4AIkVUKusRgNOBRZIA" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="unqtYV5AeEOgOCuJHP2VSA" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="3c-jtL_dbEWL8UkSLccwew" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="bpZDuWciwU2LDzUNVjrx2A" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="clICbJmt2k2C0q4avdjEGg" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="WlVW33RvI0izDWhDdH2ACw" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="C5UVPm6F9Uu9kvsRvcewKA" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="lZaz3UUV6EeQOunL9WZ4_g" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="N6fFxMUcv0q8xOyy3HG_Vw" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Rrw6f474YEKSHP4uRn44eA" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="vq5Dm6RsM0q7w6Xwf6Hmxg" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ISc5XJAL9keMxiSzY2eArg" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="Rk5KJ1kYPE2LuKkVP5sU8w" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="-h5BLHoxy0CHvA4q7cePPA" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="Bqti4FhQlkG6JCdhHtaRig" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="5JG_BBjIek6qnerxqqbp5A" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="C9Putfy-lkWMZA3fXikH6g" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="9Avqn_lfmkOYWTl8-_rMmg" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="Q7sOSh3ddkm3HisR8GYX5Q" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ucHi0vXPN0WPpok-4cCWCQ" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="RiMgPcWaPkiuXEOFfVnFRg" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Q7JAceEGmkCCiLcIdSgVFg" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="pjNILy4qJ0Sc7QJyKynHBQ" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cg3-HM5rEkyKAe6nt4Tgnw" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="99Qps1F2c0-oPHw8Cbjnwg" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="rI_XOwPh-kSUkyS48tdLCw" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="pqyQoduhGk2dZvhiWw4O6g" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="2MsqcDgQ9kWp8tSdr6OMJQ" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="p77YpPMGQkmMjPLx225DYg" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="fRQlUllt4kGqcKWlmlGP7g" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="7gkFmJlIHk29nLHrPXsCfg" name="Sum of active process rates" description="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="qY1872oWqU6lb_ZS2GZPhg" isDefault="1" displayUnit="µmol/min">
+                        <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="wkYNC-hVmEueXGrmLKrL8w" name="Sum of passive process rates" description="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="nTBDQ9zVd0uBisDJhGf56w" isDefault="1" displayUnit="µmol/min">
+                        <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Transport id="T9ezYQmcgkGFffTr1XuPHw" name="DrugAbsorption_trans" description="Drug absorption transcellular" mode="Logical" containerType="Transport" dimension="Amount per time" formula="Vw4SZ4jfKkGwCeBY4j3n5g" sourceAmount="Q5OEj64gBkqtBIJ7GLeeGw" targetAmount="WXFcEn0RZU-hAd-SnN8AKQ">
+                        <Children>
+                          <Parameter id="pXX04XNsOECq05RmyrwuMQ" name="ProcessRate" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="p_d9TogaqEiXlZcViT8rdw" isDefault="1" displayUnit="µmol/min">
+                            <Tags>
+                              <Tag value="DrugAbsorption_trans" />
+                              <Tag value="ProcessRate" />
+                              <Tag value="Aciclovir" />
+                              <Tag value="Lumen_coltrans_ColonTransversum_cell" />
+                              <Tag value="Passive" />
+                            </Tags>
+                            <Info flag="6" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                        </Children>
+                      </Transport>
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="r4maxUezKESkd-FldustEg" name="ColonTransversum_pls_PortalVein_pls" description="Neighborhood between Colon Transversum/Plasma and PortalVein/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="VsgWfVKXeUyOdIOdNnIPwA" secondNeighbor="s_QiQGLN10Omt7YLmTFwjg">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / Plasma" />
+                </Tags>
+                <Children>
+                  <Container id="ai5ekmbuaUet1HCLwyiKnA" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="17zPyygLF0qr26_mYkjZzg" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="E-wBTiS68E-2P0cr9zWOQQ" isDefault="1" displayUnit="µmol/min">
+                        <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                      </Parameter>
+                      <Transport id="w9a9UxkD_kCq7x2UBXmuWA" name="MassTransferMucosaToPvePlasma" description="Mass transfer from Mucosa:Plasma To Portal Vein: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="1-cUKXixqUWX0X1CqLdXkg" sourceAmount="pVKp11hx2E6R7VPiZbwHDg" targetAmount="JvJXBdwv-UOGE6DoopBJuA" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="WNnRtbuk3Eyzvo_0C9k_-g" name="ColonTransversum_bc_PortalVein_bc" description="Neighborhood between Colon Transversum/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="hGPbabIhQ0KWH06UQE2RbQ" secondNeighbor="-iUsllv1MkOvPkSoihwHiA">
+                <Tags>
+                  <Tag value="Neighborhood: BloodCells / BloodCells" />
+                </Tags>
+                <Children>
+                  <Container id="-eUTgbFZYkOFR9S8NzjR8w" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="RGS_KijAFUK6OijqAZC_tw" name="Mass transfer rate (mucosa to portal vein blood cells)" description="Mass transfer rate (mucosa to portal vein blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="7Og7P-ZExEmVf2QSvIQahw" isDefault="1" displayUnit="µmol/min">
+                        <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                      </Parameter>
+                      <Transport id="VZSxiY0i0UC0sYTQ_YGdlg" name="MassTransferMucosaToPveBC" description="Mass transfer from Mucosa:Blood Cells To Portal Vein: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="I0RddB1wW0uNUNPQU4lCPQ" sourceAmount="B0qtuVLp9EKHz5VWRWskcw" targetAmount="RCAqJaBNgE-vkuaKfPZpnw" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="-9XDlLxbN02PwdmqiJ7e2w" name="Lumen_coldesc_ColonDescendens_pls" description="Neighborhood between Lumen/Colon Descendens and Mucosa/Colon Descendens/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="V5WMpuj5yEWwcXqu6PUWjQ" secondNeighbor="P-Rbv420dU-i31SJUJoEVQ">
+                <Tags>
+                  <Tag value="Neighborhood: ColonDescendens / Plasma" />
+                </Tags>
+                <Children>
+                  <Container id="-K_3rUxw0ku_jiPg1zlu_Q" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="AmgVaQcJRku4gGsoLARAIg" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Bbw35Jfb_UG4xIWMel6zQQ" isDefault="1" displayUnit="µmol/min">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                      </Parameter>
+                      <Parameter id="eZOI8hUziEqhyRoSMFARjg" name="Sum of active process rates" description="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="nSQOavMwmEiAv_Mh-lA50A" isDefault="1" displayUnit="µmol/min">
+                        <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="7QCW7BLElUGkNa5gWkFF2w" name="Sum of passive process rates" description="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Imw2Xc-GME-G-l8QuTdiLA" isDefault="1" displayUnit="µmol/min">
+                        <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="QtbAaq-1U0uYXjEoHhtf_A" name="Lumen_coldesc_ColonDescendens_cell" description="Neighborhood between Lumen/Colon Descendens and Mucosa/Colon Descendens/Intracellular" mode="Logical" containerType="Neighborhood" firstNeighbor="V5WMpuj5yEWwcXqu6PUWjQ" secondNeighbor="ElVZCkQsfUuMh4sC6i18Uw">
+                <Tags>
+                  <Tag value="Neighborhood: ColonDescendens / Intracellular" />
+                </Tags>
+                <Children>
+                  <Container id="86L2wc53AE2V1NXNwpilxA" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="X0Wyt2BH5kixXVg4TuxNmA" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="OLaUQicJakC1ahiGpV3O5w" isDefault="1" displayUnit="µmol/min">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                      </Parameter>
+                      <Parameter id="YuDTKAp_p0ir5EPpfEbskQ" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="3y6-m8wgOEKD3GtEjz0zzg" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="a8weDF7GfEKGV3od-yn24Q" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="lJ91Y9prMU-IAOmp8VeUZA" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="kAUmpzwOQEye5Ci4hdXOEA" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="yEvTzBuFhEym3tsCcEU83A" isDefault="1">
+                        <Info min="0" flag="36" seq="1" ref="0" bb="2" group="67" />
+                      </Parameter>
+                      <Parameter id="JIcsU6SMjEW-uBrdT6JQAg" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="x5DLzNivEkmx2N2aSlq5Fw" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+                      </Parameter>
+                      <Parameter id="3eOi_NOzuU20kCpeJUpHtw" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="hpXqhL1180ChJO2wlTAAVQ" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="Rbq1ZCr0fUuZUMhw6vQ8Lg" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="P7ZWpALAyUCXq3R0osz6jg" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="SIC4EFGqVUSxwHYUarPaBw" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="QrLuomlr2k6FiC62k-U-6Q" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="Os39n-J6KU2spkevxZKYMw" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="lfuixO3kjEW_DgVwm-NEkA" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="_2axSEKXUUG41pyew1KyoQ" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="wpZOWtsCVEivIawZ0cJTQQ" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="87DfAyVcr0i4Wp5x0gzLLA" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="zDjvv8qD_0q6sFClKz_6Dw" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="6Mw4tZgTeECE0TH-u8u6Ig" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IIYsrx_Fhkm3HVhCSgi4JA" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="KlRjHmslFUqBOJ8VDC5suQ" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="unqtYV5AeEOgOCuJHP2VSA" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="I_4LH2S9lkeuRfqqdtkakA" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="bpZDuWciwU2LDzUNVjrx2A" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="VcUXR6GDSEq3xTqNVTAPNg" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="WlVW33RvI0izDWhDdH2ACw" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="0tM8KdtO4Uuf3_2UWHTkgw" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="lZaz3UUV6EeQOunL9WZ4_g" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="Zz98QZrxr0GJ57RgPgBNgA" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="F3uQKUESKEqS_JAv9uPMtA" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="HHT3ZDO9dUSV1_b7VuBY6Q" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="M69elIid9k-UDIo6JalSbQ" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="xE7A65MGu0K5AXKIfN_pKQ" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="vc4pMfo4wkiLKKMLxCdO4g" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="M9BL5Il76ESjTmf2Txrx0Q" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="5JG_BBjIek6qnerxqqbp5A" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="PaIUy_vSnE-yGDh6C2oCVQ" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="9Avqn_lfmkOYWTl8-_rMmg" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="6WbWo9v18UymyYe0VveAqQ" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ucHi0vXPN0WPpok-4cCWCQ" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="rUtoEA_QeEWNjk4vjTPGtA" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Q7JAceEGmkCCiLcIdSgVFg" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="2i8dAsP320mhJHBPRlP0qg" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cg3-HM5rEkyKAe6nt4Tgnw" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="Vw8PYjwUEkSNuMCKP2QNYw" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="rI_XOwPh-kSUkyS48tdLCw" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="JIcO9AovGEaAd_kyVZrqKg" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="2MsqcDgQ9kWp8tSdr6OMJQ" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="vEL39yWy50WkOBpiqbKqMw" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="fRQlUllt4kGqcKWlmlGP7g" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="rncNB5SX-0ib837-4drHvg" name="Sum of active process rates" description="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="_wxsRy4lA0OdfvyGo2_Kfg" isDefault="1" displayUnit="µmol/min">
+                        <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="R0rhQyO280qoDjP4rQrrBw" name="Sum of passive process rates" description="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="z0nUm2c8A0WvhFY3puM6nQ" isDefault="1" displayUnit="µmol/min">
+                        <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Transport id="5I64DLiI2kGUwGPs19E0vQ" name="DrugAbsorption_trans" description="Drug absorption transcellular" mode="Logical" containerType="Transport" dimension="Amount per time" formula="tOnoFJqecU67DJg427W8Fw" sourceAmount="C6DyIFKpeEmKqHkrCOLznw" targetAmount="RLjjqtjktUmVEZwhOKiC5w">
+                        <Children>
+                          <Parameter id="3Q3csExz30K-1F0tQ64hyQ" name="ProcessRate" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="offC3iB4eU6DqrRPTxjueA" isDefault="1" displayUnit="µmol/min">
+                            <Tags>
+                              <Tag value="DrugAbsorption_trans" />
+                              <Tag value="ProcessRate" />
+                              <Tag value="Aciclovir" />
+                              <Tag value="Lumen_coldesc_ColonDescendens_cell" />
+                              <Tag value="Passive" />
+                            </Tags>
+                            <Info flag="6" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                        </Children>
+                      </Transport>
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="WdOYiUfGbUG4AhEuU3aB5Q" name="ColonDescendens_pls_PortalVein_pls" description="Neighborhood between Colon Descendens/Plasma and PortalVein/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="P-Rbv420dU-i31SJUJoEVQ" secondNeighbor="s_QiQGLN10Omt7YLmTFwjg">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / Plasma" />
+                </Tags>
+                <Children>
+                  <Container id="1YH3esfdYUSizjuEW0Sc4w" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="nV2xusOPckybi-sfa0FwoQ" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="kiXEStgFGEqM2l7sI_aETg" isDefault="1" displayUnit="µmol/min">
+                        <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                      </Parameter>
+                      <Transport id="FSWYDtYIpE6Qyyb9GkQeQQ" name="MassTransferMucosaToPvePlasma" description="Mass transfer from Mucosa:Plasma To Portal Vein: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="C-xEC-IHyk2w-0EqSJ5vEg" sourceAmount="482dd-88D02lBVskSk8Wsw" targetAmount="JvJXBdwv-UOGE6DoopBJuA" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="gtK5nQbZc0e1D8JV7Bm0-w" name="ColonDescendens_bc_PortalVein_bc" description="Neighborhood between Colon Descendens/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="F1M6UAdAQ0-_GF-yyYZDGw" secondNeighbor="-iUsllv1MkOvPkSoihwHiA">
+                <Tags>
+                  <Tag value="Neighborhood: BloodCells / BloodCells" />
+                </Tags>
+                <Children>
+                  <Container id="W1UfyErF7EW6Th1MtYmMRg" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="SKQeSX9o-0uQ6fxw9AZ8Tw" name="Mass transfer rate (mucosa to portal vein blood cells)" description="Mass transfer rate (mucosa to portal vein blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="vMIjeNkFEEKsFq-7VxiLDQ" isDefault="1" displayUnit="µmol/min">
+                        <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                      </Parameter>
+                      <Transport id="JPjGTapxBEiBbD0aHfQSUQ" name="MassTransferMucosaToPveBC" description="Mass transfer from Mucosa:Blood Cells To Portal Vein: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="HwH1S56C3kGJGiejng8RiQ" sourceAmount="BMXInBiGn0mr_9IW4lNpFA" targetAmount="RCAqJaBNgE-vkuaKfPZpnw" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="tkasvr4TIUqe7CETDmZA0A" name="Lumen_colsigm_ColonSigmoid_pls" description="Neighborhood between Lumen/Colon Sigmoid and Mucosa/Colon Sigmoid/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="QrFcARY080K42hhS9X8Hvg" secondNeighbor="XdIMAdC9gUGtpu_ZPQO26A">
+                <Tags>
+                  <Tag value="Neighborhood: ColonSigmoid / Plasma" />
+                </Tags>
+                <Children>
+                  <Container id="jCUNbNzx80ax114kAVBN-g" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="6cSSJOBaPUGUUU7EJODhVg" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="yiXqzFmRnUKF-FgDVcFijg" isDefault="1" displayUnit="µmol/min">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                      </Parameter>
+                      <Parameter id="RlEm5lKECU2RLAO8MDvV3w" name="Sum of active process rates" description="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="gitSrh3R70Shpfkh72TpWA" isDefault="1" displayUnit="µmol/min">
+                        <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="1BLJyDS9vkmgS54SwsPi5g" name="Sum of passive process rates" description="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="meLPWflaUkOtBYjh3RWc1w" isDefault="1" displayUnit="µmol/min">
+                        <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="LTWV1ubEjk-WyDW0FCE7mw" name="Lumen_colsigm_ColonSigmoid_cell" description="Neighborhood between Lumen/Colon Sigmoid and Mucosa/Colon Sigmoid/Intracellular" mode="Logical" containerType="Neighborhood" firstNeighbor="QrFcARY080K42hhS9X8Hvg" secondNeighbor="PSUOMlWl50mlkNqBQIQxiw">
+                <Tags>
+                  <Tag value="Neighborhood: ColonSigmoid / Intracellular" />
+                </Tags>
+                <Children>
+                  <Container id="gBLV2hPi6ku_RIxPgH_EXQ" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="Gh6Z04ltVUKT1efPNLRRqA" name="Drug absorption rate (lumen to mucosa)" description="Drug Absorption Lumen to Mucosa Rate" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="4IWXlE6FlE6SyJ4hthuxmA" isDefault="1" displayUnit="µmol/min">
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                      </Parameter>
+                      <Parameter id="eyhkgcb5N0-gPZXJN8FImQ" name="P_int_trans_cell_lum_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="3y6-m8wgOEKD3GtEjz0zzg" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="BW0knIZKJEG4J6ZTNHmaQg" name="P_int_trans_lum_cell_factor" description="Factor modifying the intestinal permeability (transcellular) of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="lJ91Y9prMU-IAOmp8VeUZA" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="QqYuFznxgUiBItOMMwhuzA" name="Partition coefficient (intracellular/plasma)" description="Partition coefficient between intracellular space and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="8kl_aW7RdUWlrDPL9-ptKQ" isDefault="1">
+                        <Info min="0" flag="36" seq="1" ref="0" bb="2" group="67" />
+                      </Parameter>
+                      <Parameter id="DMhhOp5QDUiFLdKeESobNw" name="Partition coefficient (intracellular/water)" description="Partition coefficient (intracellular/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="8UJCTxqChECCcozjZ2lOgw" isDefault="1">
+                        <Info min="0" flag="54" seq="1" ref="0" bb="2" group="67" />
+                      </Parameter>
+                      <Parameter id="ERZg5Zyu00Kc0M6F5LjkIA" name="pKa_pH_WS_cell_F1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="6SnE5tyudEGClUOHZHwpbg" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="trL320uh90ukf7zQXbkPBQ" name="pKa_pH_WS_cell_F2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="vsuOt-oXnkugNGa1nq_fSg" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="HudUPy68s0O3SpCtGpLuxA" name="pKa_pH_WS_cell_F3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ymeYcEhCi0yIGw4Bh5GtEA" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="IxMtWSQGwUif10ykqa9ESQ" name="pKa_pH_WS_cell_K1" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="lfuixO3kjEW_DgVwm-NEkA" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="8NuHLoexYUms4zILuEDs4Q" name="pKa_pH_WS_cell_K2" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="wpZOWtsCVEivIawZ0cJTQQ" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="hxHXmDHdnUScWbbKDMCLfw" name="pKa_pH_WS_cell_K3" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="zDjvv8qD_0q6sFClKz_6Dw" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="MjGao1l4Fkm2YZCzzJ5OGw" name="pKa_pH_WS_cell_K4" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IIYsrx_Fhkm3HVhCSgi4JA" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="lzcuyUhwJE-PjRNKs8I-_A" name="pKa_pH_WS_cell_K5" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="unqtYV5AeEOgOCuJHP2VSA" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="8og8t63nK0CenZ4xqGq5dQ" name="pKa_pH_WS_cell_K6" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="bpZDuWciwU2LDzUNVjrx2A" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="c7x0ye5W9UuCx0jYDS5ZWw" name="pKa_pH_WS_cell_K7" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="WlVW33RvI0izDWhDdH2ACw" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="L29T3kXj20usanbW7t9gkQ" name="pKa_pH_WS_cell_K8" description="Supporting parameter for calculation of pKa- and pH- dependent values like solubilty, intestinal permeability, cellular permeability (WS)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="lZaz3UUV6EeQOunL9WZ4_g" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="kwPdUu_Iy0Cr6c8zo02ALQ" name="pKa_pH_WS_lum_F1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="EhKgLC12Y0WLIoyf9jQ2mw" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="-OfkNJ7QjkSi-obdHVWeXg" name="pKa_pH_WS_lum_F2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="LTSPJuLMu0qlDRf0JNOlQA" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="lDXRbULu7kWGZuUKRwGb1Q" name="pKa_pH_WS_lum_F3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="FX-hW00wbEqRf_6iyEbT3A" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="i_SPmS0RPUedLtm0YPLvlg" name="pKa_pH_WS_lum_K1" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="5JG_BBjIek6qnerxqqbp5A" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="AfH2iLmnGk-R9CQf9fZ3gQ" name="pKa_pH_WS_lum_K2" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="9Avqn_lfmkOYWTl8-_rMmg" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="fIqLJkE0NUWqeLjX6_-U3g" name="pKa_pH_WS_lum_K3" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ucHi0vXPN0WPpok-4cCWCQ" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="K1whquEYLkGb7rsehvdpqw" name="pKa_pH_WS_lum_K4" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Q7JAceEGmkCCiLcIdSgVFg" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="V3TYLMWPlUqFfSvtb-h1yg" name="pKa_pH_WS_lum_K5" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Cg3-HM5rEkyKAe6nt4Tgnw" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="zskS-pR8U0mk7HbDoSKxVA" name="pKa_pH_WS_lum_K6" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="rI_XOwPh-kSUkyS48tdLCw" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="0V8WHIjsBUOLu4q5MO5ABA" name="pKa_pH_WS_lum_K7" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="2MsqcDgQ9kWp8tSdr6OMJQ" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="Yu_4alP8D0itdinVt94YEw" name="pKa_pH_WS_lum_K8" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="fRQlUllt4kGqcKWlmlGP7g" isDefault="1">
+                        <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="75" />
+                      </Parameter>
+                      <Parameter id="t-rMiuqvx0eRzUpNhHByaw" name="Sum of active process rates" description="Sum of active process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="fyybxvYWoUybi3BJXW-aEg" isDefault="1" displayUnit="µmol/min">
+                        <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Parameter id="P2FLRYKWL0O9vog-F_tWeA" name="Sum of passive process rates" description="Sum of passive process rates" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="dvXi2ISTdUiN9uuP2WkENw" isDefault="1" displayUnit="µmol/min">
+                        <Info flag="52" seq="1" ref="0" bb="2" group="117" />
+                      </Parameter>
+                      <Transport id="tooec3o-FU2HCNZwsw0gDg" name="DrugAbsorption_trans" description="Drug absorption transcellular" mode="Logical" containerType="Transport" dimension="Amount per time" formula="2k-FLjwbW0i_rqK3P008gQ" sourceAmount="Fza7BQhGyUqFqjma1_gXAQ" targetAmount="hAH4gRJJZU-e1rGkz_z79A">
+                        <Children>
+                          <Parameter id="1ZY-EazB5kebU_Gg74tHBQ" name="ProcessRate" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="VDYm4GqMOEuf5NVvHCwD4w" isDefault="1" displayUnit="µmol/min">
+                            <Tags>
+                              <Tag value="DrugAbsorption_trans" />
+                              <Tag value="ProcessRate" />
+                              <Tag value="Aciclovir" />
+                              <Tag value="Lumen_colsigm_ColonSigmoid_cell" />
+                              <Tag value="Passive" />
+                            </Tags>
+                            <Info flag="6" seq="1" ref="0" bb="2" group="117" />
+                          </Parameter>
+                        </Children>
+                      </Transport>
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="6huEccq9FU6EvakzAGZ_uQ" name="ColonSigmoid_pls_PortalVein_pls" description="Neighborhood between Colon Sigmoid/Plasma and PortalVein/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="XdIMAdC9gUGtpu_ZPQO26A" secondNeighbor="s_QiQGLN10Omt7YLmTFwjg">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / Plasma" />
+                </Tags>
+                <Children>
+                  <Container id="X__wO-R4tEqI1zInQf1BsQ" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="B46ST27BAUuj_Ykv_uiT3g" name="Mass transfer rate (mucosa to portal vein plasma)" description="Mass transfer rate (mucosa to portal vein plasma)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="Bsf4tVEn8kyKFp00v1wqJw" isDefault="1" displayUnit="µmol/min">
+                        <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                      </Parameter>
+                      <Transport id="Grl2JOELAk6g0lkdMcePvQ" name="MassTransferMucosaToPvePlasma" description="Mass transfer from Mucosa:Plasma To Portal Vein: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="Qv8YQF0l80a2fG5odfagEQ" sourceAmount="RfGZnC_3Ck6c4ycMzqk92Q" targetAmount="JvJXBdwv-UOGE6DoopBJuA" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="Vy-mfDBu0ESSIWuAM9y0kg" name="ColonSigmoid_bc_PortalVein_bc" description="Neighborhood between Colon Sigmoid/Blood Cells and PortalVein/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="LEpMQdfgRkWrirgrcKIj7A" secondNeighbor="-iUsllv1MkOvPkSoihwHiA">
+                <Tags>
+                  <Tag value="Neighborhood: BloodCells / BloodCells" />
+                </Tags>
+                <Children>
+                  <Container id="gLx-gXaKAkOGDQ-nfba59g" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Parameter id="nPE8s0T1pESq9bLQpFBPYw" name="Mass transfer rate (mucosa to portal vein blood cells)" description="Mass transfer rate (mucosa to portal vein blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount per time" quantityType="Parameter" negativeValuesAllowed="1" formula="TvJTR6cobU66ZFaHcynxgA" isDefault="1" displayUnit="µmol/min">
+                        <ValueOrigin id="35" source="Publication" description="Willmann S, Lippert J, Sevestre M, Solodenko J, Fois F, Schmitt W. PK-Sim®: a physiologically based pharmacokinetic ‘whole-body’ model. Biosilico. 2003; 1 (4): 121-124. http://dx.doi.org/10.1016/S1478-5382%2803%2902342-4" />
+                        <Info min="0" flag="52" seq="1" ref="0" bb="2" group="39" />
+                      </Parameter>
+                      <Transport id="k31Cwm6jSUSPUYtkLG4k0w" name="MassTransferMucosaToPveBC" description="Mass transfer from Mucosa:Blood Cells To Portal Vein: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="rBddTRLXsEObQBrDg38LXQ" sourceAmount="KCragzk5OEWZZOrYQdbBjw" targetAmount="RCAqJaBNgE-vkuaKfPZpnw" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="x_1y81GhnE-VpnHNFQ_ePg" name="Duodenum_cell__VenousBlood_pls" description="Neighborhood between SmallIntestine/Mucosa/Duodenum/Interstitial and Venous Blood/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="Vo76JuhYy02oPyD6ImT7LQ" secondNeighbor="7Skx_VpY1kGT74Rns_5puw">
+                <Tags>
+                  <Tag value="Neighborhood: Interstitial / Plasma" />
+                </Tags>
+                <Children>
+                  <Container id="Z5DBuHvfQkO4dVVGwUsilw" name="Aciclovir" mode="Logical" containerType="Molecule" />
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="jsXATXyvIEeDgBdvtTeIuA" name="UpperJejunum_cell__VenousBlood_pls" description="Neighborhood between SmallIntestine/Mucosa/UpperJejunum/Interstitial and Venous Blood/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="9BNnxREkqkyzR0WtWnKqAw" secondNeighbor="7Skx_VpY1kGT74Rns_5puw">
+                <Tags>
+                  <Tag value="Neighborhood: Interstitial / Plasma" />
+                </Tags>
+                <Children>
+                  <Container id="SMdx7KwSX0uXfdoTwWKckw" name="Aciclovir" mode="Logical" containerType="Molecule" />
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="nGX_-vXgaUmLX-HeQgDFxw" name="LowerJejunum_cell__VenousBlood_pls" description="Neighborhood between SmallIntestine/Mucosa/LowerJejunum/Interstitial and Venous Blood/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="GzTlzCxSCkKQdR_RVBxrwg" secondNeighbor="7Skx_VpY1kGT74Rns_5puw">
+                <Tags>
+                  <Tag value="Neighborhood: Interstitial / Plasma" />
+                </Tags>
+                <Children>
+                  <Container id="huIe5QMa0UKBP8S0U2TlWg" name="Aciclovir" mode="Logical" containerType="Molecule" />
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="Q8xOC1Ow9EWm-GcomKaJzA" name="UpperIleum_cell__VenousBlood_pls" description="Neighborhood between SmallIntestine/Mucosa/UpperIleum/Interstitial and Venous Blood/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="ndUKDPX3lEy2sG1SyfoKVw" secondNeighbor="7Skx_VpY1kGT74Rns_5puw">
+                <Tags>
+                  <Tag value="Neighborhood: Interstitial / Plasma" />
+                </Tags>
+                <Children>
+                  <Container id="0_AiJ8CCXUe6DU_NEZKm5w" name="Aciclovir" mode="Logical" containerType="Molecule" />
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="Cqt3I562EUCNpMA71f-ysQ" name="LowerIleum_cell__VenousBlood_pls" description="Neighborhood between SmallIntestine/Mucosa/LowerIleum/Interstitial and Venous Blood/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="Wnba1ow11EO4EE9bl1feuQ" secondNeighbor="7Skx_VpY1kGT74Rns_5puw">
+                <Tags>
+                  <Tag value="Neighborhood: Interstitial / Plasma" />
+                </Tags>
+                <Children>
+                  <Container id="ipBFeVgZE0Ohy6Ty1NFJ7A" name="Aciclovir" mode="Logical" containerType="Molecule" />
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="qXqucCDVZkG5swFy_wWVHQ" name="Caecum_cell__VenousBlood_pls" description="Neighborhood between LargeIntestine/Mucosa/Cecum/Interstitial and Venous Blood/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="hd_e-QNvhEOYeLezeWUy1g" secondNeighbor="7Skx_VpY1kGT74Rns_5puw">
+                <Tags>
+                  <Tag value="Neighborhood: Interstitial / Plasma" />
+                </Tags>
+                <Children>
+                  <Container id="XSeOIcXabUWNbtWrhPct-A" name="Aciclovir" mode="Logical" containerType="Molecule" />
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="d_ShWcAXHk24gmK4BpXvwg" name="ColonAscendens_cell__VenousBlood_pls" description="Neighborhood between LargeIntestine/Mucosa/ColonAscendens/Interstitial and Venous Blood/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="WmJ-WsXVDEimc6NYz6O-CA" secondNeighbor="7Skx_VpY1kGT74Rns_5puw">
+                <Tags>
+                  <Tag value="Neighborhood: Interstitial / Plasma" />
+                </Tags>
+                <Children>
+                  <Container id="H3pPtuB3606MYLA0AblOVg" name="Aciclovir" mode="Logical" containerType="Molecule" />
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="6N669O2oRUmyweAKI6UNlA" name="ColonTransversum_cell__VenousBlood_pls" description="Neighborhood between LargeIntestine/Mucosa/ColonTransversum/Interstitial and Venous Blood/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="Bu6xSFBmck2Ur0vpd2XWDA" secondNeighbor="7Skx_VpY1kGT74Rns_5puw">
+                <Tags>
+                  <Tag value="Neighborhood: Interstitial / Plasma" />
+                </Tags>
+                <Children>
+                  <Container id="DBcGXJHq6k2Y_nLTWF546g" name="Aciclovir" mode="Logical" containerType="Molecule" />
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="i3n-WBGz6EK-MYW7Zy-mUg" name="ColonDescendens_cell__VenousBlood_pls" description="Neighborhood between LargeIntestine/Mucosa/ColonDescendens/Interstitial and Venous Blood/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="zynzBIZtn06uGL5gZqZXTA" secondNeighbor="7Skx_VpY1kGT74Rns_5puw">
+                <Tags>
+                  <Tag value="Neighborhood: Interstitial / Plasma" />
+                </Tags>
+                <Children>
+                  <Container id="zdiyqE6npUewseYDiTeIdg" name="Aciclovir" mode="Logical" containerType="Molecule" />
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="bynN_DmbXkWJXo-JiKp1qg" name="ColonSigmoid_cell__VenousBlood_pls" description="Neighborhood between LargeIntestine/Mucosa/ColonSigmoid/Interstitial and Venous Blood/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="kBF-HCFoIEuAti28q7xE3A" secondNeighbor="7Skx_VpY1kGT74Rns_5puw">
+                <Tags>
+                  <Tag value="Neighborhood: Interstitial / Plasma" />
+                </Tags>
+                <Children>
+                  <Container id="x8Hm7FfXYkKIN-cD7eSOWg" name="Aciclovir" mode="Logical" containerType="Molecule" />
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="rXlLn6sg-U6N0NqfVNJmYg" name="Rectum_cell__VenousBlood_pls" description="Neighborhood between LargeIntestine/Mucosa/Rectum/Interstitial and Venous Blood/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="EicGUlMO106zYp-0WDBzYA" secondNeighbor="7Skx_VpY1kGT74Rns_5puw">
+                <Tags>
+                  <Tag value="Neighborhood: Interstitial / Plasma" />
+                </Tags>
+                <Children>
+                  <Container id="TRiACdcXTk2-Mpt9H3twaw" name="Aciclovir" mode="Logical" containerType="Molecule" />
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="cU48HmInwUCvwAmyzr9gOw" name="Periportal_pls_Pericentral_pls" description="Neighborhood between Liver/Periportal/Plasma and Liver/Pericentral/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="MdB187oio0-foD_cFf6VMg" secondNeighbor="nMmv0kFQ_kWYQzIhWEinuQ">
+                <Children>
+                  <Container id="1mzMPazBYUCdLbx8fns8gA" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="91yGHAkKT06vbrvRy1V_sg" name="MassTransfer_PeriportalToPericentral_Plasma" description="Mass transfer from Liver Periportal Plasma to Liver Pericentral Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="U1CfqcrSkku9bi6lUb7zsw" sourceAmount="S_D_72AW7kC50sVDYbL6kg" targetAmount="as_T4ZrleUmCMyQ2xi_8gQ" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="Rpx9u595FUyJDKuxZlzGRQ" name="Periportal_bc_Pericentral_bc" description="Neighborhood between Liver/Periportal/Blood Cells and Liver/Pericentral/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="p0PJVnbRnk2esgod-s-YpQ" secondNeighbor="hdm7_1fsfUmYOyYmPmNQ-A">
+                <Children>
+                  <Container id="7G12OeheeEeeeE22GcET-A" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="ZsDX36saN0GjXYixox3D9A" name="MassTransfer_PeriportalToPericentral_BC" description="Mass transfer from Liver Periportal Blood Cells to Liver Pericentral Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="IQ9LxXettkmYgiewFtQNmA" sourceAmount="q8orlQFozEmoeJ0uL0XwLQ" targetAmount="kjr24I7cNk6rkfnQhZPKzA" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="f4nNAgmET0S4BtQCF6xpGQ" name="ArterialBlood_bc_Periportal_bc" description="Neighborhood between Arterial Blood/Blood Cells and Liver/Periportal/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="FtxmOVy3hEyMCuullB4l-A" secondNeighbor="p0PJVnbRnk2esgod-s-YpQ">
+                <Tags>
+                  <Tag value="Neighborhood: BloodCells / BloodCells" />
+                </Tags>
+                <Children>
+                  <Container id="jmdIgFAeG0ilmeB7SjE05Q" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="-aRyMk1Sdk2UVMKBCVlWoA" name="MassTransferBloodPool2OrgRBC" description="Mass transfer from ArterialBlood: BloodCells to organ: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="lX8Xuabx9k2ONh7lubuMCg" sourceAmount="gVpumttaHUG12bviSHchzw" targetAmount="q8orlQFozEmoeJ0uL0XwLQ" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="3hdJ_Jp-kkCJLfNO3KFRVA" name="ArterialBlood_pls_Periportal_pls" description="Neighborhood between Arterial Blood/Plasma and Liver/Periportal/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="J4LFcXm4AkGl5yqJ_iZoPA" secondNeighbor="MdB187oio0-foD_cFf6VMg">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / Plasma" />
+                </Tags>
+                <Children>
+                  <Container id="3Y0cNta1PU6mXNeuIJ7YYQ" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="tga2LnRzNE60MmqG0pVWOQ" name="MassTransferBloodPool2OrgPl" description="Mass transfer from Arterial Blood: Plasma to organ: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="s1nJaNyqpU-ImHU_OvtRfQ" sourceAmount="Ms-OmcTJtEOdeIHT6btWvg" targetAmount="S_D_72AW7kC50sVDYbL6kg" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="A4GNq_oQOESdFbAvQvqovA" name="PortalVein_bc_Periportal_bc" description="Neighborhood between Portal Vein/Blood Cells and Liver/Periportal/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="-iUsllv1MkOvPkSoihwHiA" secondNeighbor="p0PJVnbRnk2esgod-s-YpQ">
+                <Tags>
+                  <Tag value="Neighborhood: BloodCells / BloodCells" />
+                </Tags>
+                <Children>
+                  <Container id="XWhmIDgl_kesSS63fpMT8w" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="IEvWOrh54EyVdDuKPuYcKw" name="MassTransferBloodPool2OrgRBC_liv" description="Mass transfer from Portal Vein: Blood Cells to Liver: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="vGkf_A5REkq7m81WlNrIcQ" sourceAmount="RCAqJaBNgE-vkuaKfPZpnw" targetAmount="q8orlQFozEmoeJ0uL0XwLQ" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="BV23AF0n9kqtxMXKuRJnZA" name="PortalVein_pls_Periportal_pls" description="Neighborhood between Portal Vein/Plasma and Liver/Periportal/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="s_QiQGLN10Omt7YLmTFwjg" secondNeighbor="MdB187oio0-foD_cFf6VMg">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / Plasma" />
+                </Tags>
+                <Children>
+                  <Container id="WO_wBkdMuEGRw88DxAKWdQ" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="PVIO-yqR102xupKSrkpXuw" name="MassTransferBloodPool2OrgPl_liv" description="Mass transfer from Portal Vein: Plasma to Liver: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="joNiSwdJc0-EvRujXQGVqQ" sourceAmount="JvJXBdwv-UOGE6DoopBJuA" targetAmount="S_D_72AW7kC50sVDYbL6kg" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="yph13yzgl0K0Rejaa0S8CQ" name="Pericentral_bc_VenousBlood_bc" description="Neighborhood between Liver/Pericentral/Blood Cells and Venous Blood/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="hdm7_1fsfUmYOyYmPmNQ-A" secondNeighbor="9pDSL8Nq0US2M-Z4-4NiNw">
+                <Tags>
+                  <Tag value="Neighborhood: BloodCells / BloodCells" />
+                </Tags>
+                <Children>
+                  <Container id="EOPODkIovk-KtC5pq55emw" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="AyTWjTntyUWDdYTBuS6u7g" name="MassTransferOrgRBC2BloodPool_Liv_Pericentral" description="Mass transfer from Liver: Blood Cells to Venous Blood: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="R_0EodEozUWuwBfv9GlHUw" sourceAmount="kjr24I7cNk6rkfnQhZPKzA" targetAmount="C5df-rtR9kqsgkV4ZWZUKg" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="lZp1K6fKN0ikS3XeD1Zk6Q" name="Periportal_bc_VenousBlood_bc" description="Neighborhood between Liver/Periportal/Blood Cells and Venous Blood/Blood Cells" mode="Logical" containerType="Neighborhood" firstNeighbor="p0PJVnbRnk2esgod-s-YpQ" secondNeighbor="9pDSL8Nq0US2M-Z4-4NiNw">
+                <Tags>
+                  <Tag value="Neighborhood: BloodCells / BloodCells" />
+                </Tags>
+                <Children>
+                  <Container id="_xD8rLY-8UuOmdj6hIXBFg" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="ytNxefXEJEyLZcCzQTUSMA" name="MassTransferOrgRBC2BloodPool_Liv" description="Mass transfer from Liver: Blood Cells to Venous Blood: Blood Cells" mode="Logical" containerType="Transport" dimension="Amount per time" formula="9RXn6avEp0aiwRE7pAUAdQ" sourceAmount="q8orlQFozEmoeJ0uL0XwLQ" targetAmount="C5df-rtR9kqsgkV4ZWZUKg" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="DGnFx9QZh0qaB1UwVIk5jA" name="Pericentral_cell_Gallbladder" description="Neighborhood between Liver/Pericentral/Intracellular and Organism/Gallbladder" mode="Logical" containerType="Neighborhood" firstNeighbor="-LvKeSAYSkGcwROyAj_Blg" secondNeighbor="0yTaY2gd3UipyrhEBeHPwQ">
+                <Children>
+                  <Container id="78jgGxNLOkmK3-DuC_qTdg" name="Aciclovir" mode="Logical" containerType="Molecule" />
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="Fe4_Lr20H0KarZBOPLxPGQ" name="Periportal_cell_Gallbladder" description="Neighborhood between Liver/Periportal/Intracellular and Organism/Gallbladder" mode="Logical" containerType="Neighborhood" firstNeighbor="aIxbxCsVOku2QkfQy3lABw" secondNeighbor="0yTaY2gd3UipyrhEBeHPwQ">
+                <Children>
+                  <Container id="nRMA3wIeXkuifavMdJZ7pA" name="Aciclovir" mode="Logical" containerType="Molecule" />
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="iuJk5b2wr06Nc-5F-3fykA" name="Pericentral_pls_VenousBlood_pls" description="Neighborhood between Liver/Pericentral/Plasma and Venous Blood/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="nMmv0kFQ_kWYQzIhWEinuQ" secondNeighbor="7Skx_VpY1kGT74Rns_5puw">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / Plasma" />
+                </Tags>
+                <Children>
+                  <Container id="p-v8f7aefEukUqJPeR6Igg" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="WJfv0md0EkySOPTN4xbdBg" name="MassTransferOrgPl2BloodPool_Liv_Pericentral" description="Mass transfer from Liver: Plasma to Venous Blood: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="iB5wBHb1fEG9wN9lVkMg4Q" sourceAmount="as_T4ZrleUmCMyQ2xi_8gQ" targetAmount="7Rbeovs3_k-ueQGXqYkAXw" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="h5ZLuOdLG0SKIgtiuE9j7A" name="Periportal_pls_VenousBlood_pls" description="Neighborhood between Liver/Periportal/Plasma and Venous Blood/Plasma" mode="Logical" containerType="Neighborhood" firstNeighbor="MdB187oio0-foD_cFf6VMg" secondNeighbor="7Skx_VpY1kGT74Rns_5puw">
+                <Tags>
+                  <Tag value="Neighborhood: Plasma / Plasma" />
+                </Tags>
+                <Children>
+                  <Container id="y6FOMesXD0mZTtSMBH7jSA" name="Aciclovir" mode="Logical" containerType="Molecule">
+                    <Children>
+                      <Transport id="sphcfXAhEUqFfUFRB-7otg" name="MassTransferOrgPl2BloodPool_Liv" description="Mass transfer from Liver: Plasma to Venous Blood: Plasma" mode="Logical" containerType="Transport" dimension="Amount per time" formula="QVdpixEksEWRMzIynLUv4g" sourceAmount="S_D_72AW7kC50sVDYbL6kg" targetAmount="7Rbeovs3_k-ueQGXqYkAXw" />
+                    </Children>
+                  </Container>
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="vA5tgA0CWU-HdZNhccuCcA" name="Pericentral_cell_Lumen_duo" description="Neighborhood between Liver/Pericentral/Intracellular and Lumen/Duodenum" mode="Logical" containerType="Neighborhood" firstNeighbor="-LvKeSAYSkGcwROyAj_Blg" secondNeighbor="FiXHspIznEeQWrX1VkMsyg">
+                <Tags>
+                  <Tag value="Neighborhood: Intracellular / Duodenum" />
+                </Tags>
+                <Children>
+                  <Container id="jHGEtDLTzU62IMF1-SgAXg" name="Aciclovir" mode="Logical" containerType="Molecule" />
+                </Children>
+              </Neighborhood>
+              <Neighborhood id="SzimzyhTRUOuOhbpgBWFWQ" name="Periportal_cell_Lumen_duo" description="Neighborhood between Liver/Periportal/Intracellular and Lumen/Duodenum" mode="Logical" containerType="Neighborhood" firstNeighbor="aIxbxCsVOku2QkfQy3lABw" secondNeighbor="FiXHspIznEeQWrX1VkMsyg">
+                <Tags>
+                  <Tag value="Neighborhood: Intracellular / Duodenum" />
+                </Tags>
+                <Children>
+                  <Container id="U7-n-4Nnsk6ubAqFY89zAw" name="Aciclovir" mode="Logical" containerType="Molecule" />
+                </Children>
+              </Neighborhood>
+            </Children>
+          </Container>
+          <Container id="QtkV8pFqwUeU85RNgZx-iQ" name="Aciclovir" icon="DRUG" mode="Logical" containerType="Molecule">
+            <Children>
+              <Parameter id="U4mJS0GZr0qhZO1fYtXV2Q" name="Default Intestinal permeability (transcellular)" description="Default Intestinal permeability via transcellular route" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="aRtsF8uRNkSZSd_tQn0Jhg" buildMode="Global" isDefault="1" displayUnit="cm/min">
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="xKwYZs23xUqVsvYQ_bbuyQ" name="Intestinal permeability (paracellular)" description="Intestinal permeability via paracellular route" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Global" isDefault="1" value="0" displayUnit="cm/min">
+                <ValueOrigin id="47" source="Publication" description="Kuepfer, L., Niederalt, C., Wendl, T., Schlender, J.-F., Willmann, S., Lippert, J., Block, M., Eissing, T. and Teutonico, D. (2016), Applied Concepts in PBPK Modeling: How to Build a PBPK/PD Model. CPT Pharmacometrics Syst. Pharmacol., 5: 516–531. doi:10." />
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="SGOl1S0kokeHInDP_YK9RA" name="Intestinal permeability (transcellular)" description="Intestinal permeability via transcellular route" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="xndhch8vtkm5_jTKx13Utw" buildMode="Global" isDefault="1" displayUnit="cm/min">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="3cMLVci5aU2AAN84T2Y6Zg" name="Mucosa permeability scale factor (transcellular)" description="Used for scaling mucosa permeability with intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="QfYJlWFjZUyRyzKTk0nzrw" buildMode="Global" isDefault="1">
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="6UjVlHh6ckSbwqnXloLlFw" name="P (blood cells-&gt;plasma)" description="Permeability from blood cells to plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="Zl4F71zrYE-RtR75UN60zw" buildMode="Global" isDefault="1" displayUnit="cm/min">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="x8CJrgUSQ0mU2uFTTkdZLA" name="P (plasma-&gt;blood cells)" description="Permeability from plasma to blood cells" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="J2bh7lf8skqa6cfyuEHM9g" buildMode="Global" isDefault="1" displayUnit="cm/min">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="PCwroU1b106pHnaK0mDvFQ" name="P_bc_pls_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Global" isDefault="1" value="1">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="Y4L7V9EueEmi-TNZ0afedg" name="P_pls_bc_factor" description="Factor modifying the permeability of acids and bases depending on their degree of dissociation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Global" isDefault="1" value="1">
+                <Info min="0" flag="54" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="DijJ2Yc0NkaYWpeiUnyMYQ" name="Partition coefficient (blood cells/plasma)" description="Partition coefficient between blood cells and plasma" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="pYw-snlA2UScuq-9c6fgyw" buildMode="Global" isDefault="1">
+                <Info min="0" flag="122" seq="1" ref="0" bb="2" group="67" />
+              </Parameter>
+              <Parameter id="IM0naGQrkk-FhAwZvRFsrw" name="Fraction unbound (plasma)" description="Fraction unbound in plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="yxP5vo5_-UmJPLaAUwClNw" buildMode="Global" isDefault="1">
+                <Info min="0" max="1" flag="62" seq="3" ref="0" bb="2" group="146" />
+              </Parameter>
+              <Parameter id="dDpaJhym7UuMZs9FsOjmYg" name="Blood/Plasma concentration ratio" description="Blood to plasma concentration ratio" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DTh3TlAahUSD_ej0-b1kXQ" buildMode="Global" isDefault="1">
+                <Info min="0" flag="122" seq="10" ref="0" bb="2" group="67" />
+              </Parameter>
+              <Parameter id="IzF0DbzHbUyuxccI5pYOTA" name="base_For_KaPL_Factor" description="Supporting parameter for calculation of pKa- and pH- dependent values of KaPL" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="20">
+                <ValueOrigin id="34" source="Publication" description="Toxicol In Vitro. 2008 Mar;22(2):457-67 https://doi.org/10.1016/j.tiv.2007.09.010" />
+                <Info min="0" flag="36" seq="1" ref="0" bb="4" group="16" />
+              </Parameter>
+              <Parameter id="zBs1-TYT20ibd3KGAxosVA" name="base_For_logD_Factor" description="Supporting parameter for calculation of pKa- and pH- dependent logD" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0.001">
+                <ValueOrigin id="34" source="Publication" description="Toxicol In Vitro. 2008 Mar;22(2):457-67 https://doi.org/10.1016/j.tiv.2007.09.010" />
+                <Info min="0" flag="36" seq="1" ref="0" bb="4" group="16" />
+              </Parameter>
+              <Parameter id="ra1Gz1vDm0ibXGnYAfcXZg" name="base_For_P_cell_Factor" description="Supporting parameter for calculation of pKa- and pH- dependent permeability to/from cells" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0.001">
+                <Info min="0" flag="36" seq="1" ref="0" bb="4" group="16" />
+              </Parameter>
+              <Parameter id="mhdHgkm-i0CMe0HojJsveg" name="base_For_Pint_Factor" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0.1">
+                <Info min="0" flag="36" seq="1" ref="0" bb="4" group="16" />
+              </Parameter>
+              <Parameter id="BP4ACa9sw0SxgYH0NvVrwQ" name="BP_AGP" description="Constant for binding partner α1-acid glycoprotein" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0">
+                <Info flag="52" seq="1" ref="0" bb="4" group="9" />
+              </Parameter>
+              <Parameter id="H9ALTDYsYUe3l_Z0M-CsFA" name="BP_ALBUMIN" description="Constant for binding partner albumin" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="1">
+                <Info flag="52" seq="1" ref="0" bb="4" group="9" />
+              </Parameter>
+              <Parameter id="cnBKzVu6JUWfQyLzCEKV9A" name="BP_UNKNOWN" description="Constant for binding partner unknown" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="2">
+                <Info flag="52" seq="1" ref="0" bb="4" group="9" />
+              </Parameter>
+              <Parameter id="CxWB6TcC50mi8iXwWHIlIg" name="Br" description="Number of bromine atoms in molecule" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0">
+                <Info min="0" max="10" flag="58" seq="1" ref="0" bb="4" group="13" />
+              </Parameter>
+              <Parameter id="iJZvmfCxMUWojq_CPqnjTg" name="Calculated specific intestinal permeability (transcellular)" description="Calculated specific intestinal permeability (transcellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="T1ziNG6WyU-CvhjkUGBMZg" buildMode="Global" isDefault="1" displayUnit="cm/min">
+                <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="a5lVBFt6nECv9fTNNYM-zQ" name="Cl" description="Number of chlorine atoms in molecule" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0">
+                <Info min="0" max="10" flag="58" seq="1" ref="0" bb="4" group="13" />
+              </Parameter>
+              <Parameter id="PonQ-UN4mE2n_Rm4GmS3IQ" name="Compound type 0" description="Compound type (-1: acid, +1: base, 0: neutral)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="-1">
+                <Info min="-1" max="1" flag="58" seq="1" ref="0" bb="4" group="16" />
+              </Parameter>
+              <Parameter id="jFJlhF0MgUOzrDhgoz-jJA" name="Compound type 1" description="Compound type (-1: acid, +1: base, 0: neutral)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="1">
+                <Info min="-1" max="1" flag="58" seq="1" ref="0" bb="4" group="16" />
+              </Parameter>
+              <Parameter id="V-sSWo9-9ESsgldtEOo9PQ" name="Compound type 2" description="Compound type (-1: acid, +1: base, 0: neutral)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0">
+                <Info min="-1" max="1" flag="58" seq="1" ref="0" bb="4" group="16" />
+              </Parameter>
+              <Parameter id="kxdVyLFyo0ekkro80V433A" name="CT_ACID" description="Constant for compound type acid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="-1">
+                <Info min="-1" max="-1" flag="52" seq="1" ref="0" bb="4" group="16" />
+              </Parameter>
+              <Parameter id="fzKGnEPv0UKd7tCcATparw" name="CT_BASE" description="Constant for compound type base" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="1">
+                <Info min="1" max="1" flag="52" seq="1" ref="0" bb="4" group="16" />
+              </Parameter>
+              <Parameter id="ad_-LlDgrEapks9BgTDHpg" name="CT_NEUTRAL" description="Constant for compound type neutral" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0">
+                <Info min="0" max="0" flag="52" seq="1" ref="0" bb="4" group="16" />
+              </Parameter>
+              <Parameter id="qVpWYrZrpEmdwDVCFLtWMg" name="Effective molecular weight" description="Effective molecular weight" icon="Parameter" persistable="0" isFixedValue="0" dim="Molecular weight" quantityType="Parameter" negativeValuesAllowed="1" formula="0jvwKzf-Vk23gGZ2kwx2pQ" buildMode="Property" isDefault="1" displayUnit="g/mol">
+                <ValueOrigin id="25" source="Publication" description="Stefan Willmann, Walter Schmitt,Jörg Keldenich, Jörg Lippert, and Jennifer B. Dressman: A Physiological Model for the Estimation of the Fraction Dose Absorbed in Humans. J. Med. Chem. 2004, 47, 4022-4031" />
+                <Info min="1.5E-08" flag="62" seq="1" ref="0" bb="4" group="13" />
+              </Parameter>
+              <Parameter id="YOqlnNLbXk2Bf0hnEv2Qhg" name="F" description="Number of fluorine atoms in molecule" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0">
+                <Info min="0" max="10" flag="58" seq="1" ref="0" bb="4" group="13" />
+              </Parameter>
+              <Parameter id="oWwNWx_bhUW7rqb1sCTQCw" name="Has halogens" description="Supporting parameter for compound" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="qqgI0ZT6PUOJQ8yjdKNSbQ" buildMode="Property" isDefault="1">
+                <Info min="0" flag="60" seq="1" ref="0" bb="4" group="13" />
+              </Parameter>
+              <Parameter id="HE1vi4UDXke0mYUS8JvZqQ" name="I" description="Number of iodine atoms in molecule" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0">
+                <Info min="0" max="10" flag="58" seq="1" ref="0" bb="4" group="13" />
+              </Parameter>
+              <Parameter id="35rCSqarLEKsaLLYInKV2w" name="Is diprotic acid" description="Is diprotic acid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="RBejlHbyX0u3nll-5QnygA" buildMode="Property" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="4" group="16" />
+              </Parameter>
+              <Parameter id="14OhxYRVe0ijMQqiNMUBGQ" name="Is diprotic base" description="Is diprotic base" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="8HRTNT9UvUSlhSJvRY0sXw" buildMode="Property" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="4" group="16" />
+              </Parameter>
+              <Parameter id="cw7FwExdtEq658lcaDXiGg" name="Is diprotic base monoprotic acid" description="Is diprotic base monoprotic acid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TsDlPEV5k0iqzk9W26bu5w" buildMode="Property" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="4" group="16" />
+              </Parameter>
+              <Parameter id="jN7BgqRZaUydjgSCougs0A" name="Is floating in lumen" description="Is floating in lumen" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="4" group="9" />
+              </Parameter>
+              <Parameter id="q43JbFYG1EeVC6CuPfmXTA" name="Is monoprotic acid" description="Is monoprotic acid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="1sNtrR5c5EmT2zM97AN39Q" buildMode="Property" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="4" group="16" />
+              </Parameter>
+              <Parameter id="PGXBQ13cwk-VU78o_xO0Cg" name="Is monoprotic base" description="Is monoprotic base" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lkti7ADNRk6-_lFyV_rkyg" buildMode="Property" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="4" group="16" />
+              </Parameter>
+              <Parameter id="7k2ViI5uG0isqljDZds0OQ" name="Is monoprotic base diprotic acid" description="Is monoprotic base diprotic acid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="e0c2KLQ4PEy2UtSqxFyKMA" buildMode="Property" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="4" group="16" />
+              </Parameter>
+              <Parameter id="9KSwt9-ljkeHPVGCg85Whg" name="Is monoprotic base monoprotic acid" description="Is monoprotic base monoprotic acid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BfLSNw2__0Cv09DXhFC-nA" buildMode="Property" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="4" group="16" />
+              </Parameter>
+              <Parameter id="FYZiOwryv0-9E6qQlgs2pg" name="Is neutral" description="Supporting parameter for partition coeffs in RR-Modell" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Pp2GixAj0EeliYqbjhoIoA" buildMode="Property" isDefault="1">
+                <Info min="0" flag="52" seq="1" ref="0" bb="4" group="16" />
+              </Parameter>
+              <Parameter id="m71yQLwAp0GfY0IDxLNmaw" name="Is small molecule" description="Treat compound as small molecule or not (if not, both organ specific and intestinal permeability will be set to zero)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="0" value="1">
+                <Info min="0" max="1" flag="60" seq="1" ref="0" bb="4" group="9" />
+              </Parameter>
+              <Parameter id="mOgVsJ5MCka_2dBTJENCrg" name="Is strong base" description="Supporting parameter for partition coeffs in RR-Modell (at least one basic pKa&gt;=7)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="G9Un4MX4UE6Nb_-lvKyZuQ" buildMode="Property" isDefault="1">
+                <Info min="0" flag="52" seq="1" ref="0" bb="4" group="16" />
+              </Parameter>
+              <Parameter id="dQiUoM6lh0SoG704QJlcSA" name="Is triprotic acid" description="Is triprotic acid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="qYCdLIdsLECGvHYXs62iBQ" buildMode="Property" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="4" group="16" />
+              </Parameter>
+              <Parameter id="wZOhaF8ul0KbvEWDJrnSfw" name="Is triprotic base" description="Is triprotic base" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="3wY1EWFRy0WnJJqjR_psIg" buildMode="Property" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="4" group="16" />
+              </Parameter>
+              <Parameter id="AUKU0Kj1-Ea4nKgZobOuaw" name="Molecular weight" description="Molecular weight" icon="Parameter" persistable="0" isFixedValue="0" dim="Molecular weight" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="0" value="2.2521E-07" displayUnit="g/mol">
+                <Info min="1.5E-08" flag="56" seq="1" ref="0" bb="4" group="13" />
+              </Parameter>
+              <Parameter id="k4PSGbVvN02cRMgVQ73Dsw" name="pKa value 0" description="pKa value" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="9.2">
+                <Info min="0" max="14" flag="58" seq="1" ref="0" bb="4" group="16" />
+              </Parameter>
+              <Parameter id="PTD2pbFFSE-_mWEZGPoX2g" name="pKa value 1" description="pKa value" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="2.2">
+                <Info min="0" max="14" flag="58" seq="1" ref="0" bb="4" group="16" />
+              </Parameter>
+              <Parameter id="HziT3MQ3bk-r61EyKVq-Uw" name="pKa value 2" description="pKa value" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0">
+                <Info min="0" max="14" flag="58" seq="1" ref="0" bb="4" group="16" />
+              </Parameter>
+              <Parameter id="rSkko-0iyEmC5Vy_T7I5ZQ" name="pKa_Acid_0" description="Smallest acid pKa" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="GN15w618Dku9WjZbIUoBxw" buildMode="Property" isDefault="1">
+                <Info min="0" max="14" flag="52" seq="1" ref="0" bb="4" group="16" />
+              </Parameter>
+              <Parameter id="J9si61kTfE-I2X-Swx9Rog" name="pKa_Acid_1" description="Middle acid pKa" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="qo7xQs0IIEO_Hyw4btum9Q" buildMode="Property" isDefault="1">
+                <Info min="0" max="14" flag="52" seq="1" ref="0" bb="4" group="16" />
+              </Parameter>
+              <Parameter id="b5kdtSVFUkC2QKatt_sOWg" name="pKa_Acid_2" description="Largest acid pKa" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="3VTB01TojEStyXp_1Ll-5Q" buildMode="Property" isDefault="1">
+                <Info min="0" max="14" flag="52" seq="1" ref="0" bb="4" group="16" />
+              </Parameter>
+              <Parameter id="Q65rAS3T00-6babdISW1NQ" name="pKa_Acids_Count" description="Number of acidic groups in compound" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="NRL4WeZ56kq9mnSzGq0KAA" buildMode="Property" isDefault="1">
+                <Info min="0" max="3" flag="52" seq="1" ref="0" bb="4" group="16" />
+              </Parameter>
+              <Parameter id="m17-0Aoy2E-VuWOcOmlgFA" name="pKa_Base_0" description="Smallest base pKa" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="NkHyqrKCsUyhWs0xXx_NNA" buildMode="Property" isDefault="1">
+                <Info min="0" max="14" flag="52" seq="1" ref="0" bb="4" group="16" />
+              </Parameter>
+              <Parameter id="yEsr6f-d8Ua2t6RW3d1dZA" name="pKa_Base_1" description="Middle base pKa" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Eoid3OIwvEeE1Zm3gGPSLA" buildMode="Property" isDefault="1">
+                <Info min="0" max="14" flag="52" seq="1" ref="0" bb="4" group="16" />
+              </Parameter>
+              <Parameter id="7LQ2UDrdsEmD4hrxDFawcw" name="pKa_Base_2" description="Largest base pKa" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="dZNI4LdiuU-sKCGkAUPfWw" buildMode="Property" isDefault="1">
+                <Info min="0" max="14" flag="52" seq="1" ref="0" bb="4" group="16" />
+              </Parameter>
+              <Parameter id="agCUTuwma0yMqxOTR7-FhA" name="pKa_Bases_Count" description="Number of basic groups in compound" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="x-FcTagea0eKTxvj-FInSQ" buildMode="Property" isDefault="1">
+                <Info min="0" max="3" flag="52" seq="1" ref="0" bb="4" group="16" />
+              </Parameter>
+              <Parameter id="B7pxZ-WJgEqROopdFL64sA" name="pKa_OneAcid_0" description="Smallest acid pKa for compound with 1 acid group" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="GURYnl3FjUSmgG3jxm69lg" buildMode="Property" isDefault="1">
+                <Info min="0" max="14" flag="52" seq="1" ref="0" bb="4" group="16" />
+              </Parameter>
+              <Parameter id="0RLsd28P2ECmqu__IrO7RA" name="pKa_OneBase_0" description="Smallest base pKa for compound with 1 base group" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="sGYq3xeW5UuEYw5LC_foYg" buildMode="Property" isDefault="1">
+                <Info min="0" max="14" flag="52" seq="1" ref="0" bb="4" group="16" />
+              </Parameter>
+              <Parameter id="EPkXonaMkU21K5X2elkDjQ" name="pKa_pH_WS_sol_F1" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="NlPKYqGDFkCWGOGzP983jA" buildMode="Property" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="4" group="18" />
+              </Parameter>
+              <Parameter id="YfVJHlX2jkeykjcQgjd-AQ" name="pKa_pH_WS_sol_F2" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="b8tjj-mfDUuPfXorlJtmDw" buildMode="Property" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="4" group="18" />
+              </Parameter>
+              <Parameter id="zX2lWDlM5kKKOKZJ-haMVw" name="pKa_pH_WS_sol_F3" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="WiFrjDWaO0ChSEy7acmNNg" buildMode="Property" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="4" group="18" />
+              </Parameter>
+              <Parameter id="v2dhjvG_u0mx1zkXTZJ-Rw" name="pKa_pH_WS_sol_K1" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="c56vweNnREiYItHYjmOegw" buildMode="Property" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="4" group="18" />
+              </Parameter>
+              <Parameter id="AKdYjMTbqE6iuLReF66Wog" name="pKa_pH_WS_sol_K2" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="HIaE_gMMUEOpkyn0JJ4gog" buildMode="Property" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="4" group="18" />
+              </Parameter>
+              <Parameter id="jiZmq27vD0eAOpAsVlwEhQ" name="pKa_pH_WS_sol_K3" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="aqrmzlWCK0uhjPMceIUk8A" buildMode="Property" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="4" group="18" />
+              </Parameter>
+              <Parameter id="ghW6gFWak06jwjYfqsQvvA" name="pKa_pH_WS_sol_K4" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="6Rv4vw3TPk-RGWUDccSQLw" buildMode="Property" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="4" group="18" />
+              </Parameter>
+              <Parameter id="XM0JQ7-xO0W1OQYZEUTy7g" name="pKa_pH_WS_sol_K5" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="j33fDWhc4karxHgjnWVprQ" buildMode="Property" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="4" group="18" />
+              </Parameter>
+              <Parameter id="b4JD6XvltUaPt_z4RZE9vQ" name="pKa_pH_WS_sol_K6" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="uh1KR6kKekiTuCGdUmf1KQ" buildMode="Property" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="4" group="18" />
+              </Parameter>
+              <Parameter id="NbrAuiq32k-8OAjwmXLQUA" name="pKa_pH_WS_sol_K7" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="257tkUoAhkShftuDt9ZizQ" buildMode="Property" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="4" group="18" />
+              </Parameter>
+              <Parameter id="sPJPv56cu0e2mXXKqdshyA" name="pKa_pH_WS_sol_K8" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="fxs1PK5_3kKhBYBbIVgc1g" buildMode="Property" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="4" group="18" />
+              </Parameter>
+              <Parameter id="bstjKc1CrkWfQADr9UnnRQ" name="pKa_ThreeAcids_0" description="Smallest acid pKa for compound with 3 acid groups" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="5-8xoiyB10qX9rnhyfG7Lw" buildMode="Property" isDefault="1">
+                <Info min="0" max="14" flag="52" seq="1" ref="0" bb="4" group="16" />
+              </Parameter>
+              <Parameter id="rqM-iU7bCUOHYonjdu1PMw" name="pKa_ThreeAcids_1" description="Middle acid pKa for compound with 3 acid groups" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="vbg6yXXO50K9TMEg0wEw5Q" buildMode="Property" isDefault="1">
+                <Info min="0" max="14" flag="52" seq="1" ref="0" bb="4" group="16" />
+              </Parameter>
+              <Parameter id="x7ha_PlW30WKx2h64HjuMQ" name="pKa_ThreeBases_0" description="Smallest base pKa for compound with 3 base groups" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="xvxIyuj-vkSJCDwn3iRWxA" buildMode="Property" isDefault="1">
+                <Info min="0" max="14" flag="52" seq="1" ref="0" bb="4" group="16" />
+              </Parameter>
+              <Parameter id="29IFbAwAVUuk7WI1pvpx2g" name="pKa_ThreeBases_1" description="Middle base pKa for compound with 3 base groups" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="pujB5Dly_UuwL6iCxMQqiw" buildMode="Property" isDefault="1">
+                <Info min="0" max="14" flag="52" seq="1" ref="0" bb="4" group="16" />
+              </Parameter>
+              <Parameter id="OzNIXrRC202Q_Qpc0EVEMw" name="pKa_TwoAcids_0" description="Smallest acid pKa for compound with 2 acid groups" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="WN5lhTsjKEuZhTjKxdiPig" buildMode="Property" isDefault="1">
+                <Info min="0" max="14" flag="52" seq="1" ref="0" bb="4" group="16" />
+              </Parameter>
+              <Parameter id="oUUEhRwVs0ay5k6RE5wx1w" name="pKa_TwoAcids_1" description="Middle acid pKa for compound with 2 acid groups" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="3BgOvM9Uc0e1ooS6u8PsMQ" buildMode="Property" isDefault="1">
+                <Info min="0" max="14" flag="52" seq="1" ref="0" bb="4" group="16" />
+              </Parameter>
+              <Parameter id="-JBU1-wefkKOUKDg3onsaQ" name="pKa_TwoBases_0" description="Smallest base pKa for compound with 2 base groups" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="QRxvFqMcxkSMu_m-kUyOeA" buildMode="Property" isDefault="1">
+                <Info min="0" max="14" flag="52" seq="1" ref="0" bb="4" group="16" />
+              </Parameter>
+              <Parameter id="rM_NC2Qw7U-V9z-MisTRUQ" name="pKa_TwoBases_1" description="Middle base pKa for compound with 2 base groups" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="bM7Tr24z5EqI7TtTCJ-Nhg" buildMode="Property" isDefault="1">
+                <Info min="0" max="14" flag="52" seq="1" ref="0" bb="4" group="16" />
+              </Parameter>
+              <Parameter id="OqqALL_T6UKyaynu1CFEQQ" name="Plasma protein binding partner" description="Plasma protein to which the drug is predominantly bound. The ontogeny of the two most important plasma protein binding partners, albumin and α1-acid glycoprotein (AGP) is available in the PK-Sim database so that the fraction unbound in plasma can be scaled to children using the ontogeny of the respective protein. If  the binding partner is neither albumin nor AGP  or if scaling to children is not of interest, the third alternative (unknown) can be used. Please note that any other ontogeny can be uploaded for the scaling to children using the Population Simulation Toolbox in MoBi" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="0" value="1">
+                <Info flag="58" seq="1" ref="0" bb="4" group="9" />
+              </Parameter>
+              <Parameter id="N8MoL9gVfUaQz4ZcL8ocbw" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="uqReMOWJlUimN7E6NBB0vA" buildMode="Property" isDefault="1">
+                <Info min="0" flag="52" seq="1" ref="0" bb="4" group="18" />
+              </Parameter>
+              <Parameter id="DOCmhyvr9UeTKdOF3Sl74Q" name="Total drug mass" description="Total drug mass" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" formula="fT-rkXkMgkqoN5veBio9mg" buildMode="Property" isDefault="1" displayUnit="µmol">
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="9" />
+              </Parameter>
+              <Parameter id="YhG-axGTV0uDio2zxUQoAg" name="Total oral drug mass" description="Total oral drug mass" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0" displayUnit="µmol">
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="63" />
+              </Parameter>
+              <Parameter id="UG4diRnWTk6KCpaWD5gqsw" name="Lipophilicity" description="Model dependent lipophilicity measure: LogMA / LogP / ..." icon="Parameter" persistable="0" isFixedValue="0" dim="Log Units" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="0" value="-0.097" displayUnit="Log Units">
+                <Info min="-10" max="10" flag="58" seq="2" ref="0" bb="4" group="12" />
+              </Parameter>
+              <Parameter id="MAGbi4e2z0iBBE_vdQZujw" name="Fraction unbound (plasma, reference value)" description="Fraction unbound in plasma of the reference individual, i.e. in the case of human typically an average healthy adult. This reference value can be scaled to children based on the ontogeny of the respective plasma protein and/or in diseased subjects using the plasma protein scale factor defined in the individual" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="0" value="0.85">
+                <Info min="0" max="1" flag="106" seq="3" ref="0" bb="4" group="10" />
+              </Parameter>
+              <Parameter id="dmBqlJMifUCnrpngMZ8AxA" name="Solubility at reference pH" description="Solubility at reference pH" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="0" value="0.03399" displayUnit="mg/l">
+                <Info min="0" flag="122" seq="4" ref="0" bb="4" group="18" />
+              </Parameter>
+              <Parameter id="Xih9H8a-AUeg_8ThOtZQNw" name="Solubility table" description="Solubility table" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0" displayUnit="mg/l">
+                <Info min="0" flag="48" seq="4" ref="0" bb="4" group="18" />
+              </Parameter>
+              <Parameter id="Iph4IIgZr0Sm8jbPqCOhzQ" name="Reference pH" description="Reference pH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="0" value="7">
+                <Info min="0" max="14" flag="58" seq="5" ref="0" bb="4" group="18" />
+              </Parameter>
+              <Parameter id="fY2bUg7tdk-fhVRh1osAIw" name="Solubility gain per charge" description="Supporting parameter for calculation of pKa- and pH- dependent values of intestinal solubilty" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="1000">
+                <Info min="0" flag="42" seq="6" ref="0" bb="4" group="18" />
+              </Parameter>
+              <Parameter id="mIaN3Iorf0SVEhJ4ZTTm8w" name="Permeability" description="Permeability" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="IYaSddNJwEeSMvYcb7E0XQ" buildMode="Property" isDefault="1" displayUnit="cm/min">
+                <Info min="0" flag="62" seq="7" ref="0" bb="4" group="15" />
+              </Parameter>
+              <Parameter id="JbYSVzzj70mtfe4hl3D9EA" name="Specific intestinal permeability (transcellular)" description="Specific intestinal permeability (transcellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="T1ziNG6WyU-CvhjkUGBMZg" buildMode="Property" isDefault="1" displayUnit="cm/min">
+                <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
+                <Info min="0" flag="62" seq="8" ref="0" bb="4" group="11" />
+              </Parameter>
+              <Parameter id="0Lng1J405kijUBS23T7zEw" name="Partition coefficient (water/protein)" description="Partition coefficient water to protein" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="IoxZdeLvS0eZpFnqY8XlYg" buildMode="Global" isDefault="1">
+                <Info min="0" flag="122" seq="9" ref="0" bb="2" group="67" />
+              </Parameter>
+              <Parameter id="Ip4bZShPOUOYK7JmtrAJBw" name="Treat precipitated drug as" description="Treat precipitated drug as either soluble or insoluble" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="1">
+                <Info min="0" max="1" flag="58" seq="30" ref="0" bb="4" group="14" />
+              </Parameter>
+              <Parameter id="rCyAynbqIkaMB7fyea1z2A" name="Aqueous diffusion coefficient" description="Aqueous diffusion coefficient&#xA;of the drug" icon="Parameter" persistable="0" isFixedValue="0" dim="Diffusion coefficient" quantityType="Parameter" negativeValuesAllowed="1" formula="hdNZCzUM3EqYDe6_jpFgIg" buildMode="Property" isDefault="1" displayUnit="cm²/min">
+                <ValueOrigin id="32" source="Publication" description="Willmann S, Thelen K, Becker C, et al. Mechanism-based prediction of particle size-dependent dissolution and absorption: cilostazol pharmacokinetics in dogs. Eur J Pharm Biopharm. 2010 Sep;76(1):83-94 https://doi.org/10.1016/j.ejpb.2010.06.003" />
+                <Info min="6E-13" max="0.6" flag="58" seq="31" ref="0" bb="4" group="14" />
+              </Parameter>
+              <Parameter id="IYbKxEc-gUenuR8Cbpjz2w" name="Density (drug)" description="Density of drug material" icon="Parameter" persistable="0" isFixedValue="0" dim="Density" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="1" displayUnit="g/cm³">
+                <ValueOrigin id="32" source="Publication" description="Willmann S, Thelen K, Becker C, et al. Mechanism-based prediction of particle size-dependent dissolution and absorption: cilostazol pharmacokinetics in dogs. Eur J Pharm Biopharm. 2010 Sep;76(1):83-94 https://doi.org/10.1016/j.ejpb.2010.06.003" />
+                <Info min="2.5E-06" flag="58" seq="32" ref="0" bb="4" group="14" />
+              </Parameter>
+              <Parameter id="GZRcwhekNkOoll8XdMmYvw" name="Immediately dissolve particles smaller than" description="Threshold for the particle radius of immediate dissolution" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="1E-07" displayUnit="µm">
+                <ValueOrigin id="32" source="Publication" description="Willmann S, Thelen K, Becker C, et al. Mechanism-based prediction of particle size-dependent dissolution and absorption: cilostazol pharmacokinetics in dogs. Eur J Pharm Biopharm. 2010 Sep;76(1):83-94 https://doi.org/10.1016/j.ejpb.2010.06.003" />
+                <Info min="1E-35" flag="58" seq="33" ref="0" bb="4" group="14" />
+              </Parameter>
+              <Parameter id="9J2UVfDQGUGWZCMF2FJTxA" name="Radius (solute)" description="Solute radius" icon="Parameter" persistable="0" isFixedValue="0" dim="Length" quantityType="Parameter" negativeValuesAllowed="1" formula="fmnNAvvzQUWb0n8K1bRs5A" buildMode="Property" isDefault="1" displayUnit="µm">
+                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                <Info min="0" flag="58" seq="40" ref="0" bb="4" group="19" />
+              </Parameter>
+              <Parameter id="-qQlx8UyIkeRAF7fMYqyuA" name="Kd (FcRn) in endosomal space" description="Dissociation constant of drug for binding to FcRn in endosomal space" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="999999" displayUnit="µmol/l">
+                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                <Info min="0" flag="58" seq="41" ref="0" bb="4" group="19" />
+              </Parameter>
+              <Parameter id="H5LRPSNP2UaB_2MATylHnQ" name="Kd (FcRn) in plasma/interstitial" description="Dissociation constant of drug for binding to FcRn in plasma/interstitial space. For monoclonal antibodies the binding to FcRn in neutral environment (plasma and interstitial space) is generally very weak or not detectable. In this case the high default value for Kd(FcRn) in plasma/interstitial can be kept." icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="999999" displayUnit="µmol/l">
+                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                <Info min="0" flag="58" seq="42" ref="0" bb="4" group="19" />
+              </Parameter>
+              <Parameter id="zFI3uk4HGECouCy1ZtCjYQ" name="kass (FcRn)" description="Association constant of drug for binding to FcRn" icon="Parameter" persistable="0" isFixedValue="0" dim="Second order rate constant" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0.87" displayUnit="l/µmol/min">
+                <ValueOrigin id="26" source="Publication" description="Niederalt, C., Kuepfer, L., Solodenko, J. et al. J Pharmacokinet Pharmacodyn (2017). https://doi.org/10.1007/s10928-017-9559-4" />
+                <Info min="0" flag="58" seq="43" ref="0" bb="4" group="19" />
+              </Parameter>
+              <Parameter id="WBdwzld3-0OEusPC6uF5dA" name="Use pH- and pKa-dependent penalty factor for charged molecule fraction" description="Penalty factor for charged molecule fraction is used for &quot;Intestinal permeability (transcellular)&quot; only" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Global" isDefault="1" value="0">
+                <Info min="0" max="1" flag="58" seq="100" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="FroMPqHHQU2tlZkWdkweZg" name="Enable supersaturation" description="Enabling supersaturation inactivates the limit of how much solute can be dissolved. It should always and only be allowed in combination with particle dissolution formulations; otherwise disabled. Enabling in case of other formulations results in a lack of the solubility limit and hence in infinitely soluble solutes." icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0">
+                <Info min="0" max="1" flag="58" seq="100" ref="0" bb="4" group="14" />
+              </Parameter>
+              <Parameter id="BlkaKwek2ECiLjWXoWQKOw" name="Parameter m for correlation of intestinal permeability (transcellular)" description="Parameter m for correlation of intestinal permeability (transcellular)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="1">
+                <Info flag="54" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="w1i9kmSUQUGamWTrbvg3kw" name="Parameter b for correlation of intestinal permeability (transcellular)" description="Parameter b for correlation of intestinal permeability (transcellular)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="1" value="0">
+                <Info flag="54" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+            </Children>
+          </Container>
+          <Container id="qMLZTtrhZk25U9Atqy5ffg" name="CYP344" icon="ENZYME" mode="Logical" containerType="Molecule">
+            <Children>
+              <Parameter id="qh94b5Kf9EiPxhA_x008uQ" name="Ontogeny factor" description="Ontogeny factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Global" isDefault="1" value="1">
+                <Info min="0" flag="58" seq="1" ref="0" bb="32" group="142" />
+              </Parameter>
+              <Parameter id="S4xM6nteZU2Mr_CRLh--dQ" name="Ontogeny factor GI" description="Ontogeny factor GI" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Global" isDefault="1" value="1">
+                <Info min="0" flag="58" seq="1" ref="0" bb="32" group="142" />
+              </Parameter>
+              <Parameter id="OGvWskbRCUm0Byvh0xfNdQ" name="Reference concentration" description="CYP Form | [pmol/mg HLM] | [µmol CYP/l Liver tissue]&#xD;&#xA;CYP1A2 | 45 | 1.8&#xD;&#xA;CYP2A6 | 68 | 2.72&#xD;&#xA;CYP2B6 | 39 | 1.56&#xD;&#xA;CYP2C18 | &lt;2,5 | &lt;0,1&#xD;&#xA;CYP2C19 | 19 | 0.76&#xD;&#xA;CYP2C8 | 64 | 2.56&#xD;&#xA;CYP2C9 | 96 | 3.84&#xD;&#xA;CYP2D6 | 10 | 0.4&#xD;&#xA;CYP2E1 | 49 | 1.96&#xD;&#xA;CYP3A4 | 108 | 4.32&#xD;&#xA;CYP3A5 | 1 | 0.04&#xD;&#xA;Source: Rodrigues (1999), Table2" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Global" isDefault="1" value="1" displayUnit="µmol/l">
+                <Info min="0" flag="122" seq="1" ref="0" bb="32" group="91" />
+              </Parameter>
+              <Parameter id="Pod0OiZ0jUych74IjBRgJA" name="Rel. exp. variability factor" description="Variability factor for relative expressions" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Global" isDefault="1" value="1">
+                <Info min="0" flag="54" seq="1" ref="0" bb="32" group="91" />
+              </Parameter>
+              <Parameter id="tR7aiuN3UESjgrep6k9ArQ" name="Relative expression in blood cells" description="Relative expression in blood cells" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Global" isDefault="1" value="0">
+                <Info min="0" flag="60" seq="1" ref="0" bb="32" group="91" />
+              </Parameter>
+              <Parameter id="HkDefRSpk0GNaibNdcPu1A" name="Relative expression in blood cells (normalized)" description="Relative expression norm in blood cells" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Global" isDefault="1" value="0">
+                <Info min="0" flag="58" seq="1" ref="0" bb="32" group="91" />
+              </Parameter>
+              <Parameter id="5JmqrZxME0SSKJ7ly3ZKZA" name="t1/2 (intestine)" description="Half-life of drug release in the intestine" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Global" isDefault="1" value="1380" displayUnit="h">
+                <Info min="0" flag="106" seq="1" ref="0" bb="32" group="91" />
+              </Parameter>
+              <Parameter id="uiZ8dgvSREyIrb1pf9AQew" name="t1/2 (liver)" description="Half-life of drug release in the liver" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Global" isDefault="1" value="2160" displayUnit="h">
+                <Info min="0" flag="106" seq="1" ref="0" bb="32" group="91" />
+              </Parameter>
+              <Parameter id="nR9n-TtStUGRYk5NL-kgkQ" name="Relative expression in plasma" description="Relative expression in plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Global" isDefault="1" value="0">
+                <Info min="0" flag="60" seq="2" ref="0" bb="32" group="91" />
+              </Parameter>
+              <Parameter id="0uM7VTCRGU-TdFS-0m00bQ" name="Relative expression in plasma (normalized)" description="Relative expression norm in plasma" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Global" isDefault="1" value="0">
+                <Info min="0" flag="58" seq="2" ref="0" bb="32" group="91" />
+              </Parameter>
+              <Parameter id="LpuMkloRRUSWCgC-NxrLYg" name="Relative expression in vascular endothelium" description="Relative expression in vasc. Endothelium" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Global" isDefault="1" value="0">
+                <Info min="0" flag="60" seq="3" ref="0" bb="32" group="91" />
+              </Parameter>
+              <Parameter id="xW2o6ev3qkGP9h4ZaI8Szw" name="Relative expression in vascular endothelium (normalized)" description="Relative expression in vasc. Endothelium" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Global" isDefault="1" value="0">
+                <Info min="0" flag="58" seq="3" ref="0" bb="32" group="91" />
+              </Parameter>
+              <Parameter id="WpP2iKhmIE6mcvVFcDnABw" name="base_For_KaPL_Factor" description="Supporting parameter for calculation of pKa- and pH- dependent values of KaPL" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="20">
+                <ValueOrigin id="34" source="Publication" description="Toxicol In Vitro. 2008 Mar;22(2):457-67 https://doi.org/10.1016/j.tiv.2007.09.010" />
+                <Info min="0" flag="36" seq="1" ref="0" bb="2" group="16" />
+              </Parameter>
+              <Parameter id="6FV6roFxuEqZijaUHxXtNw" name="base_For_logD_Factor" description="Supporting parameter for calculation of pKa- and pH- dependent logD" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0.001">
+                <ValueOrigin id="34" source="Publication" description="Toxicol In Vitro. 2008 Mar;22(2):457-67 https://doi.org/10.1016/j.tiv.2007.09.010" />
+                <Info min="0" flag="36" seq="1" ref="0" bb="2" group="16" />
+              </Parameter>
+              <Parameter id="xj4cxhTguEqKTrJgIhCGVg" name="base_For_P_cell_Factor" description="Supporting parameter for calculation of pKa- and pH- dependent permeability to/from cells" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0.001">
+                <Info min="0" flag="36" seq="1" ref="0" bb="2" group="16" />
+              </Parameter>
+              <Parameter id="I0nvkwOqe0i4nrsoDnAFcg" name="base_For_Pint_Factor" description="Supporting parameter for calculation of pKa- and pH- dependent intestinal permeability" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0.1">
+                <Info min="0" flag="36" seq="1" ref="0" bb="2" group="16" />
+              </Parameter>
+              <Parameter id="-5puExBQ-UeghaDVINJ0YA" name="BP_AGP" description="Constant for binding partner α1-acid glycoprotein" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0">
+                <Info flag="52" seq="1" ref="0" bb="2" group="9" />
+              </Parameter>
+              <Parameter id="AU5ZfWIANU-6x0sbvA-w1A" name="BP_ALBUMIN" description="Constant for binding partner albumin" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="1">
+                <Info flag="52" seq="1" ref="0" bb="2" group="9" />
+              </Parameter>
+              <Parameter id="-BRtswrp10qR2ufqvwC7Xw" name="BP_UNKNOWN" description="Constant for binding partner unknown" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="2">
+                <Info flag="52" seq="1" ref="0" bb="2" group="9" />
+              </Parameter>
+              <Parameter id="hKlvoxX8hkeCt-9gv7TZ0Q" name="Br" description="Number of bromine atoms in molecule" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0">
+                <Info min="0" max="10" flag="50" seq="1" ref="0" bb="2" group="13" />
+              </Parameter>
+              <Parameter id="EOGxd8nvPECVtHxmkDKECA" name="Calculated specific intestinal permeability (transcellular)" description="Calculated specific intestinal permeability (transcellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Velocity" quantityType="Parameter" negativeValuesAllowed="1" formula="T1ziNG6WyU-CvhjkUGBMZg" buildMode="Global" isDefault="1" displayUnit="cm/min">
+                <ValueOrigin id="28" source="Publication" description="Thelen K, Coboeken K, Willmann S, et al. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1:Oral solutions. J Pharm Sci. 2011 Dec;100(12):5324-45 https://doi.org/10.1002/jps.22726" />
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="75" />
+              </Parameter>
+              <Parameter id="Tov8-4F35kqAEo9ZyNo5Yg" name="Cl" description="Number of chlorine atoms in molecule" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0">
+                <Info min="0" max="10" flag="50" seq="1" ref="0" bb="2" group="13" />
+              </Parameter>
+              <Parameter id="jekhrLT7vUSMz7W766EUhQ" name="Compound type 0" description="Compound type (-1: acid, +1: base, 0: neutral)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0">
+                <Info min="-1" max="1" flag="50" seq="1" ref="0" bb="2" group="16" />
+              </Parameter>
+              <Parameter id="EwcVzEmqjU-e1vevC6XQGA" name="Compound type 1" description="Compound type (-1: acid, +1: base, 0: neutral)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0">
+                <Info min="-1" max="1" flag="50" seq="1" ref="0" bb="2" group="16" />
+              </Parameter>
+              <Parameter id="-xbfiwt7UEOd-PLe86_N0A" name="Compound type 2" description="Compound type (-1: acid, +1: base, 0: neutral)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0">
+                <Info min="-1" max="1" flag="50" seq="1" ref="0" bb="2" group="16" />
+              </Parameter>
+              <Parameter id="-v4ncFDvGU24cdXNvntpVQ" name="CT_ACID" description="Constant for compound type acid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="-1">
+                <Info min="-1" max="-1" flag="52" seq="1" ref="0" bb="2" group="16" />
+              </Parameter>
+              <Parameter id="-8sB0VI9_0-B_vyvcxJeTg" name="CT_BASE" description="Constant for compound type base" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="1">
+                <Info min="1" max="1" flag="52" seq="1" ref="0" bb="2" group="16" />
+              </Parameter>
+              <Parameter id="kZBtHDgeJkmiG2oUTLPqbg" name="CT_NEUTRAL" description="Constant for compound type neutral" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0">
+                <Info min="0" max="0" flag="52" seq="1" ref="0" bb="2" group="16" />
+              </Parameter>
+              <Parameter id="nCLPjk_hfU2bO0DQrMWGYQ" name="Effective molecular weight" description="Effective molecular weight" icon="Parameter" persistable="0" isFixedValue="0" dim="Molecular weight" quantityType="Parameter" negativeValuesAllowed="1" formula="0jvwKzf-Vk23gGZ2kwx2pQ" buildMode="Property" isDefault="1" displayUnit="g/mol">
+                <ValueOrigin id="25" source="Publication" description="Stefan Willmann, Walter Schmitt,Jörg Keldenich, Jörg Lippert, and Jennifer B. Dressman: A Physiological Model for the Estimation of the Fraction Dose Absorbed in Humans. J. Med. Chem. 2004, 47, 4022-4031" />
+                <Info min="1.5E-08" flag="54" seq="1" ref="0" bb="2" group="13" />
+              </Parameter>
+              <Parameter id="lohQfq-M-k2_Gl7Gk2Nx8g" name="F" description="Number of fluorine atoms in molecule" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0">
+                <Info min="0" max="10" flag="50" seq="1" ref="0" bb="2" group="13" />
+              </Parameter>
+              <Parameter id="yF6SLw2QAk-In_5WI5eVfw" name="Has halogens" description="Supporting parameter for compound" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="qqgI0ZT6PUOJQ8yjdKNSbQ" buildMode="Property" isDefault="1">
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="13" />
+              </Parameter>
+              <Parameter id="y6BdeweaKk-1rq-LV8oy1Q" name="I" description="Number of iodine atoms in molecule" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0">
+                <Info min="0" max="10" flag="50" seq="1" ref="0" bb="2" group="13" />
+              </Parameter>
+              <Parameter id="-FenZkhmikuwj4R3XeBdzw" name="Is diprotic acid" description="Is diprotic acid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="RBejlHbyX0u3nll-5QnygA" buildMode="Property" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="16" />
+              </Parameter>
+              <Parameter id="AY0arFCVvUS-48xYnbTMzQ" name="Is diprotic base" description="Is diprotic base" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="8HRTNT9UvUSlhSJvRY0sXw" buildMode="Property" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="16" />
+              </Parameter>
+              <Parameter id="fPdPKoUM3Eeg4Yj17sYp8A" name="Is diprotic base monoprotic acid" description="Is diprotic base monoprotic acid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="TsDlPEV5k0iqzk9W26bu5w" buildMode="Property" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="16" />
+              </Parameter>
+              <Parameter id="r_qv7ONfrkObwuSLsp8n2Q" name="Is floating in lumen" description="Is floating in lumen" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="9" />
+              </Parameter>
+              <Parameter id="FWK1qWb7kESpJCgg2IA83Q" name="Is monoprotic acid" description="Is monoprotic acid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="1sNtrR5c5EmT2zM97AN39Q" buildMode="Property" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="16" />
+              </Parameter>
+              <Parameter id="VLTawPklpkisxNU1UgCbTQ" name="Is monoprotic base" description="Is monoprotic base" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Lkti7ADNRk6-_lFyV_rkyg" buildMode="Property" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="16" />
+              </Parameter>
+              <Parameter id="4jl6X-_q40K21DYblLwQpg" name="Is monoprotic base diprotic acid" description="Is monoprotic base diprotic acid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="e0c2KLQ4PEy2UtSqxFyKMA" buildMode="Property" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="16" />
+              </Parameter>
+              <Parameter id="JjSQzhuVFEO_y5FpZ4kC5Q" name="Is monoprotic base monoprotic acid" description="Is monoprotic base monoprotic acid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="BfLSNw2__0Cv09DXhFC-nA" buildMode="Property" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="16" />
+              </Parameter>
+              <Parameter id="1h2ZZIVrgEa1KAPjsCLS5A" name="Is neutral" description="Supporting parameter for partition coeffs in RR-Modell" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Pp2GixAj0EeliYqbjhoIoA" buildMode="Property" isDefault="1">
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="16" />
+              </Parameter>
+              <Parameter id="aw11gQG2_UKuim6NzW_NtA" name="Is small molecule" description="Treat compound as small molecule or not (if not, both organ specific and intestinal permeability will be set to zero)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="9" />
+              </Parameter>
+              <Parameter id="5YLJ6vSvuUK-sWYjW9A2EQ" name="Is strong base" description="Supporting parameter for partition coeffs in RR-Modell (at least one basic pKa&gt;=7)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="G9Un4MX4UE6Nb_-lvKyZuQ" buildMode="Property" isDefault="1">
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="16" />
+              </Parameter>
+              <Parameter id="bJHeMRG7dU-wIt3JTRuJ6w" name="Is triprotic acid" description="Is triprotic acid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="qYCdLIdsLECGvHYXs62iBQ" buildMode="Property" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="16" />
+              </Parameter>
+              <Parameter id="vZEFJzW8H0S2p030Vs3afQ" name="Is triprotic base" description="Is triprotic base" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="3wY1EWFRy0WnJJqjR_psIg" buildMode="Property" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="16" />
+              </Parameter>
+              <Parameter id="eItQmiyRxU-yIAHy-GGJkQ" name="Molecular weight" description="Molecular weight" icon="Parameter" persistable="0" isFixedValue="0" dim="Molecular weight" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="NaN" displayUnit="g/mol">
+                <Info min="1.5E-08" flag="48" seq="1" ref="0" bb="2" group="13" />
+              </Parameter>
+              <Parameter id="8iVDb8-ABkuDhNAKo9qn_A" name="pKa value 0" description="pKa value" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0">
+                <Info min="0" max="14" flag="50" seq="1" ref="0" bb="2" group="16" />
+              </Parameter>
+              <Parameter id="6300CrpsjU2xtR_8VGdrIw" name="pKa value 1" description="pKa value" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0">
+                <Info min="0" max="14" flag="50" seq="1" ref="0" bb="2" group="16" />
+              </Parameter>
+              <Parameter id="gBTKSQEYxEWO1a5t1iwfqQ" name="pKa value 2" description="pKa value" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0">
+                <Info min="0" max="14" flag="50" seq="1" ref="0" bb="2" group="16" />
+              </Parameter>
+              <Parameter id="wvTKkBxXU0Cp-p7x00srrg" name="pKa_Acid_0" description="Smallest acid pKa" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="GN15w618Dku9WjZbIUoBxw" buildMode="Property" isDefault="1">
+                <Info min="0" max="14" flag="52" seq="1" ref="0" bb="2" group="16" />
+              </Parameter>
+              <Parameter id="dpsQx6FXnkyTK48e0SdEeg" name="pKa_Acid_1" description="Middle acid pKa" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="qo7xQs0IIEO_Hyw4btum9Q" buildMode="Property" isDefault="1">
+                <Info min="0" max="14" flag="52" seq="1" ref="0" bb="2" group="16" />
+              </Parameter>
+              <Parameter id="MFh4CuNR40GYVORIbAsegg" name="pKa_Acid_2" description="Largest acid pKa" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="3VTB01TojEStyXp_1Ll-5Q" buildMode="Property" isDefault="1">
+                <Info min="0" max="14" flag="52" seq="1" ref="0" bb="2" group="16" />
+              </Parameter>
+              <Parameter id="sTo4oTwXyk6ri-u3TOILew" name="pKa_Acids_Count" description="Number of acidic groups in compound" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="NRL4WeZ56kq9mnSzGq0KAA" buildMode="Property" isDefault="1">
+                <Info min="0" max="3" flag="52" seq="1" ref="0" bb="2" group="16" />
+              </Parameter>
+              <Parameter id="ORan7Cy-BkmEyN9csotL9g" name="pKa_Base_0" description="Smallest base pKa" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="NkHyqrKCsUyhWs0xXx_NNA" buildMode="Property" isDefault="1">
+                <Info min="0" max="14" flag="52" seq="1" ref="0" bb="2" group="16" />
+              </Parameter>
+              <Parameter id="MXpmmjtaykisy7xKHFxJWw" name="pKa_Base_1" description="Middle base pKa" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="Eoid3OIwvEeE1Zm3gGPSLA" buildMode="Property" isDefault="1">
+                <Info min="0" max="14" flag="52" seq="1" ref="0" bb="2" group="16" />
+              </Parameter>
+              <Parameter id="scARiZX9FkaQ_XKqWnCO8g" name="pKa_Base_2" description="Largest base pKa" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="dZNI4LdiuU-sKCGkAUPfWw" buildMode="Property" isDefault="1">
+                <Info min="0" max="14" flag="52" seq="1" ref="0" bb="2" group="16" />
+              </Parameter>
+              <Parameter id="PVDn10MfvkuIAHKr-otCGQ" name="pKa_Bases_Count" description="Number of basic groups in compound" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="x-FcTagea0eKTxvj-FInSQ" buildMode="Property" isDefault="1">
+                <Info min="0" max="3" flag="52" seq="1" ref="0" bb="2" group="16" />
+              </Parameter>
+              <Parameter id="7RShCXI-k0e0yrdDWiggOQ" name="pKa_OneAcid_0" description="Smallest acid pKa for compound with 1 acid group" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="GURYnl3FjUSmgG3jxm69lg" buildMode="Property" isDefault="1">
+                <Info min="0" max="14" flag="52" seq="1" ref="0" bb="2" group="16" />
+              </Parameter>
+              <Parameter id="utleyjUClkOWs6ePe-WLLw" name="pKa_OneBase_0" description="Smallest base pKa for compound with 1 base group" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="sGYq3xeW5UuEYw5LC_foYg" buildMode="Property" isDefault="1">
+                <Info min="0" max="14" flag="52" seq="1" ref="0" bb="2" group="16" />
+              </Parameter>
+              <Parameter id="kQbZoLmy5ka4dDGh89t_LQ" name="pKa_pH_WS_sol_F1" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="NlPKYqGDFkCWGOGzP983jA" buildMode="Property" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+              </Parameter>
+              <Parameter id="1XANCz2OOUeD0ndGsiwDFQ" name="pKa_pH_WS_sol_F2" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="b8tjj-mfDUuPfXorlJtmDw" buildMode="Property" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+              </Parameter>
+              <Parameter id="vYU2-9h56kSSiJe6V325dA" name="pKa_pH_WS_sol_F3" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="WiFrjDWaO0ChSEy7acmNNg" buildMode="Property" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+              </Parameter>
+              <Parameter id="x03B52a-9UCTRJ6APU9iwg" name="pKa_pH_WS_sol_K1" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="c56vweNnREiYItHYjmOegw" buildMode="Property" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+              </Parameter>
+              <Parameter id="aSXOBxK_Rki0y1k7AJD-MA" name="pKa_pH_WS_sol_K2" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="HIaE_gMMUEOpkyn0JJ4gog" buildMode="Property" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+              </Parameter>
+              <Parameter id="FjczArlQp0Cf0h1ujdDi7w" name="pKa_pH_WS_sol_K3" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="aqrmzlWCK0uhjPMceIUk8A" buildMode="Property" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+              </Parameter>
+              <Parameter id="_Iudr_G2oUOMQedaINzY9Q" name="pKa_pH_WS_sol_K4" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="6Rv4vw3TPk-RGWUDccSQLw" buildMode="Property" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+              </Parameter>
+              <Parameter id="jGlYSkZ04UuEDmDFOSa8Og" name="pKa_pH_WS_sol_K5" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="j33fDWhc4karxHgjnWVprQ" buildMode="Property" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+              </Parameter>
+              <Parameter id="ysRO3Qbl20qPwftS8veZSw" name="pKa_pH_WS_sol_K6" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="uh1KR6kKekiTuCGdUmf1KQ" buildMode="Property" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+              </Parameter>
+              <Parameter id="1Or42lG4Ikq7DM5kYljdUQ" name="pKa_pH_WS_sol_K7" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="257tkUoAhkShftuDt9ZizQ" buildMode="Property" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+              </Parameter>
+              <Parameter id="PzRzpexUskGrgz6Bsay7LA" name="pKa_pH_WS_sol_K8" description="Supporting parameter for calculation of pKa- and pH- dependent solubilty scale factor at refPH" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="fxs1PK5_3kKhBYBbIVgc1g" buildMode="Property" isDefault="1">
+                <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="18" />
+              </Parameter>
+              <Parameter id="5stYkJEKg028zrkiuAuZZA" name="pKa_ThreeAcids_0" description="Smallest acid pKa for compound with 3 acid groups" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="5-8xoiyB10qX9rnhyfG7Lw" buildMode="Property" isDefault="1">
+                <Info min="0" max="14" flag="52" seq="1" ref="0" bb="2" group="16" />
+              </Parameter>
+              <Parameter id="8QAWkaOoWUKWt-V1xqHaJg" name="pKa_ThreeAcids_1" description="Middle acid pKa for compound with 3 acid groups" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="vbg6yXXO50K9TMEg0wEw5Q" buildMode="Property" isDefault="1">
+                <Info min="0" max="14" flag="52" seq="1" ref="0" bb="2" group="16" />
+              </Parameter>
+              <Parameter id="QcxzGVVY-E-kk2JegkomAw" name="pKa_ThreeBases_0" description="Smallest base pKa for compound with 3 base groups" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="xvxIyuj-vkSJCDwn3iRWxA" buildMode="Property" isDefault="1">
+                <Info min="0" max="14" flag="52" seq="1" ref="0" bb="2" group="16" />
+              </Parameter>
+              <Parameter id="MClTTTLrXUqMWXguV3FyaQ" name="pKa_ThreeBases_1" description="Middle base pKa for compound with 3 base groups" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="pujB5Dly_UuwL6iCxMQqiw" buildMode="Property" isDefault="1">
+                <Info min="0" max="14" flag="52" seq="1" ref="0" bb="2" group="16" />
+              </Parameter>
+              <Parameter id="6IjWHwsWDE2pzEyIbTcM2g" name="pKa_TwoAcids_0" description="Smallest acid pKa for compound with 2 acid groups" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="WN5lhTsjKEuZhTjKxdiPig" buildMode="Property" isDefault="1">
+                <Info min="0" max="14" flag="52" seq="1" ref="0" bb="2" group="16" />
+              </Parameter>
+              <Parameter id="qPTaNvWMQ0eoJcL6jKnX_w" name="pKa_TwoAcids_1" description="Middle acid pKa for compound with 2 acid groups" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="3BgOvM9Uc0e1ooS6u8PsMQ" buildMode="Property" isDefault="1">
+                <Info min="0" max="14" flag="52" seq="1" ref="0" bb="2" group="16" />
+              </Parameter>
+              <Parameter id="Yi-sO-NfdU-6HsL_EJduOQ" name="pKa_TwoBases_0" description="Smallest base pKa for compound with 2 base groups" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="QRxvFqMcxkSMu_m-kUyOeA" buildMode="Property" isDefault="1">
+                <Info min="0" max="14" flag="52" seq="1" ref="0" bb="2" group="16" />
+              </Parameter>
+              <Parameter id="b2I-incFFkG2Ha_Us0iE4g" name="pKa_TwoBases_1" description="Middle base pKa for compound with 2 base groups" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="bM7Tr24z5EqI7TtTCJ-Nhg" buildMode="Property" isDefault="1">
+                <Info min="0" max="14" flag="52" seq="1" ref="0" bb="2" group="16" />
+              </Parameter>
+              <Parameter id="4TPESMVTm0qJaACL_EnWMg" name="Plasma protein binding partner" description="Plasma protein to which the drug is predominantly bound. The ontogeny of the two most important plasma protein binding partners, albumin and α1-acid glycoprotein (AGP) is available in the PK-Sim database so that the fraction unbound in plasma can be scaled to children using the ontogeny of the respective protein. If  the binding partner is neither albumin nor AGP  or if scaling to children is not of interest, the third alternative (unknown) can be used. Please note that any other ontogeny can be uploaded for the scaling to children using the Population Simulation Toolbox in MoBi" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="1">
+                <Info flag="50" seq="1" ref="0" bb="2" group="9" />
+              </Parameter>
+              <Parameter id="Etknh1Iq7ESLNt-mlets1w" name="Solubility_pKa_pH_Factor" description="pKa/pH-Dependent factor for solubility" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="uqReMOWJlUimN7E6NBB0vA" buildMode="Property" isDefault="1">
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="18" />
+              </Parameter>
+              <Parameter id="Br30qDVbv0Ss6XzF2c0DWw" name="Total drug mass" description="Total drug mass" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" formula="IbADS6NWMk-4z3OqEKdl4A" buildMode="Property" isDefault="1" displayUnit="µmol">
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="9" />
+              </Parameter>
+              <Parameter id="fS6I7DhLIEK0PM8MdsLZdg" name="Total oral drug mass" description="Total oral drug mass" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="0" displayUnit="µmol">
+                <Info min="0" flag="52" seq="1" ref="0" bb="2" group="63" />
+              </Parameter>
+              <Parameter id="mucE3nvmRU2Q13sF7v4_Og" name="Lipophilicity" description="Model dependent lipophilicity measure: LogMA / LogP / ..." icon="Parameter" persistable="0" isFixedValue="0" dim="Log Units" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="NaN" displayUnit="Log Units">
+                <Info min="-10" max="10" flag="50" seq="2" ref="0" bb="2" group="12" />
+              </Parameter>
+              <Parameter id="OY-oUAet9kmlfqegoIjoOw" name="Fraction unbound (plasma, reference value)" description="Fraction unbound in plasma of the reference individual, i.e. in the case of human typically an average healthy adult. This reference value can be scaled to children based on the ontogeny of the respective plasma protein and/or in diseased subjects using the plasma protein scale factor defined in the individual" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="NaN">
+                <Info min="0" max="1" flag="34" seq="3" ref="0" bb="2" group="10" />
+              </Parameter>
+              <Parameter id="rxcZN1Co7EqtN3tJHLQlag" name="Solubility at reference pH" description="Solubility at reference pH" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (mass)" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="1" value="NaN" displayUnit="mg/l">
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+              <Path path="336" as="337" />
+              <Path path="374" as="375" />
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+            <Paths>
+              <Path path="383" as="384" dim="124" />
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+          <Formula id="UmMKT-hULkiERHGJMVLGUw" name="PARAM_Outflow_Duodenum" dim="Inversed time" formula="(k_p*alpha_p*V_p+inflow-k*alpha*V)/(alpha*V)" origin="Lumen_PKSim.PARAM_Outflow_Duodenum">
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+          <Formula id="qN0sQEkpKUSNvqPOFISgPQ" name="PARAM_Lumen_Geometry_R2" dim="Length" formula="r2_p0 + Height*r2_p1" origin="Lumen_Geometry.PARAM_Lumen_Geometry_R2">
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+            <Paths>
+              <Path path="404" as="405" dim="3" />
+              <Path path="406" as="407" />
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+          <Formula id="sIXkaS02_UGII5sFXg9TKg" name="PARAM_Lumen_Geometry_Length" dim="Length" formula="L_p0 + Height*L_p1" origin="Lumen_Geometry.PARAM_Lumen_Geometry_Length">
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+          <Formula id="DPN7hsoR10mEgAQWjEMIDg" name="PARAM_LiquidTransferRate_duo" dim="Flow" formula="w*Liquid*FillLevelFlagNext" origin="Lumen_PKSim.PARAM_LiquidTransferRate_duo">
+            <Paths>
+              <Path path="311" as="312" dim="3" />
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+              <Path path="394" as="114" dim="115" />
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+          <Formula id="qD0Mle0pZkiYQ7ZcXu9m0A" name="PARAM_Inflow_Duodenum" dim="Flow" formula="0.02894*V" origin="Lumen_PKSim.PARAM_Inflow_Duodenum">
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+              <Path path="160" as="164" dim="8" />
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+          <Formula id="JHk9xtQ6YUWAs-vav0AWPg" name="PARAM_Lumen_Geometry_Thickness" dim="Length" formula="Thickness_p1 + Thickness_p2*(1-exp(Thickness_p3*Height))" origin="Lumen_Geometry.PARAM_Lumen_Geometry_Thickness">
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+              <Path path="428" as="429" dim="8" />
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+          <Formula id="yTvsKm4FhkO7sNFUuBvZVA" name="PARAM_OntogenyFactor_FromGlobal_GI" formula="f_onto" origin="gvI30fvbrUW0OZa_YN_bMA">
+            <Paths>
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+          <Formula id="OSfgBAXnF0aNkHHm7fg70A" name="PARAM_OralMassAbsorbed_RHS_duo" dim="Amount per time" formula="PassiveRates_para+PassiveRates_trans-(ActiveRates_para+ActiveRates_trans)" origin="9frV4UlVK0yrJgsIksaF-g">
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+            <Paths>
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+              <Path path="404" as="405" dim="3" />
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+            <Paths>
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+          <Formula id="zVbNhVTmZEKfGXUZBeFk1A" name="PARAM_K_cell_pls_PK-Sim_Standard" formula="(f_water + f_lipids * 10^LogMA + f_proteins * KProt) * fu">
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+          <Formula id="lkq3mD2M5kyeBDpkf_00HA" name="PassiveDiffusionInt2Cell" dim="Amount per time" formula="K_water_int * PA_int_cell * C_int - K_water_cell * PA_cell_int * C_cell">
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+              <Path path="1095" as="1096" dim="8" />
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+          <Formula id="rR9DVLGnpkG5yy-tML9Geg" name="PassiveDiffusionPl2RBC" dim="Amount per time" formula="SA_bc * fu * (P_pls_rbc * C_pls - P_rbc_pls * C_bc  /K_rbc)">
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+          <Formula id="CCV-loYpsk6XcW2Gt5U_GA" name="MassTransferOrgPl2BloodPool" dim="Amount per time" formula="Q*(1-HCT)*C_pls">
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+          <Formula id="T5xwf-IXu0mJ38J0lKuHuA" name="PARAM_K_cell_pls_PK-Sim_Standard" formula="(f_water + f_lipids * 10^LogMA + f_proteins * KProt) * fu">
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+          <Formula id="-iwvne2mXUqxG8uwmwVAbw" name="PARAM_K_water_int_kid_Schmitt" formula="fu/K_int_pls" origin="Interstitial partition coefficient method - Schmitt.PARAM_K_water_int_kid_Schmitt">
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+          <Formula id="hWMWKdj6lEe7d5BqOpbI3A" name="PassiveDiffusionInt2Cell" dim="Amount per time" formula="K_water_int * PA_int_cell * C_int - K_water_cell * PA_cell_int * C_cell">
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+          <Formula id="8QuJreAtB06qyWH3mMZ-DA" name="PARAM_SA_int_cell_kid" dim="Area" formula="(V_kid * 1000 / 7)^0.75 * 1000 * 1E2" origin="SurfaceAreaIntCell_PKSim.PARAM_SA_int_cell_kid">
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+          <Formula id="fDbSg-B_QUuQqcxyz2WIBg" name="PARAM_SA_pls_int" dim="Area" formula="k * f_vas_org * V_org">
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+          <Formula id="RTvXy1ziBUmPPDJSVo2JuA" name="PARAM_TSspec_From_TS" dim="Inversed time" formula="TS / V_kid" origin="MTAcZNwwqUGIgXCSGfcq-w">
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+          <Formula id="VlWWvvZzkUCUkGHYSHUycw" name="TubularSecretion_FirstOrder" dim="Amount per time" formula="fu * TSspec * V_kid * C_kid_pls * Renal_aging_scaling_factor" origin="fNjRPV8_HEyRrRTaAEdf6Q">
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+          <Formula id="yVVccI634kW__mycpzf-7A" name="GFR_Clearance" dim="Amount per time" formula="fu * GFRspec*GFR_Fraction* Weight_Kidney * C_kid_pls" origin="TJGpLe2sUkqrxGlA39yN0Q">
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+          <Formula id="eCY18cJN70ObTfKFkAtU6A" name="PARAM_K_wat_cell_Lumen_UpperJejunum" formula="K_water_cell" origin="DistributionCommon_PKSim.PARAM_K_wat_cell_Lumen_UpperJejunum">
+            <Paths>
+              <Path path="646" as="237" />
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+          <Formula id="_kycZRSbGEqrN3v09AAh6Q" name="PARAM_pKa_pH_WS_mucosacell_F1" formula="CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1" origin="IntestinalPermeabilityCommon_PKSim.PARAM_pKa_pH_WS_mucosacell_F1">
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+            <Paths>
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+          <Formula id="7JdCbl31IEmi5zXmdBpk8w" name="DrugAbsorption_trans" dim="Amount per time" formula="DrugAbsorptionLumenToMucosaRate">
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+          <Formula id="bzvJme-JjkOMdOvtU9FFvg" name="PARAM_MassTransferMucosaToPvePlasma" dim="Amount per time" formula="Q*(1-HCT)*C_pls">
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+          <Formula id="6jJ2dnMpnEyw4SxjbqE5mw" name="MassTransferMucosaToPvePlasma" dim="Amount per time" formula="MassTransferMucosaToPvePlasmaRate">
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+          <Formula id="C2cqpJYOxUiD_7T8Ixdv2g" name="PARAM_MassTransferMucosaToPveBloodCells" dim="Amount per time" formula="Q*HCT*C_bc">
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+          <Formula id="8N-5YA2mOkuNznVV6JfEyw" name="MassTransferOrgRBC2BloodPool" dim="Amount per time" formula="Q*HCT*C_bc">
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+          <Formula id="BdF9P4wGWEi2kQOvOit64g" name="PARAM_K_cell_pls_PK-Sim_Standard" formula="(f_water + f_lipids * 10^LogMA + f_proteins * KProt) * fu">
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+            <Paths>
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+              <Path path="152" as="190" dim="124" />
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+          <Formula id="PhrkxFVtCEiPXoqqZ_VQgQ" name="PARAM_SA_pls_int" dim="Area" formula="k * f_vas_org * V_org">
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+              <Path path="1513" as="228" dim="8" />
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+          <Formula id="BjcuzRf7yEyR13KPDSeXmw" name="MassTransferOrgPl2BloodPool" dim="Amount per time" formula="Q*(1-HCT)*C_pls">
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+              <Path path="152" as="190" dim="124" />
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+          <Formula id="eO-2dYZot021eRuziikelw" name="MassTransferOrgRBC2BloodPool_Pve" dim="Amount per time" formula="Q*HCT*C_bc">
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+              <Path path="1517" as="198" dim="124" />
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+          <Formula id="0TZF9Yg-EEGnTnojTJFViQ" name="PARAM_K_cell_pls_PK-Sim_Standard" formula="(f_water + f_lipids * 10^LogMA + f_proteins * KProt) * fu">
+            <Paths>
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+          <Formula id="YwNsPggXOkCQzuPpCs1zWQ" name="PARAM_K_water_int_spl_Schmitt" formula="fu/K_int_pls" origin="Interstitial partition coefficient method - Schmitt.PARAM_K_water_int_spl_Schmitt">
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+          <Formula id="8ckFESJlikqBoDfOkaMd5w" name="MassTransferOrgPl2BloodPool_pve" dim="Amount per time" formula="Q*(1-HCT)*C_pls">
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+          <Map s="Sim|Organism|SmallIntestine|Mucosa|UpperJejunum|Plasma|Volume" id="43" />
+          <Map s="V_pls_uje" id="44" />
+          <Map s="Sim|Organism|SmallIntestine|Mucosa|LowerJejunum|Plasma|Volume" id="45" />
+          <Map s="V_pls_lje" id="46" />
+          <Map s="Sim|Organism|SmallIntestine|Mucosa|UpperIleum|Plasma|Volume" id="47" />
+          <Map s="V_pls_uil" id="48" />
+          <Map s="Sim|Organism|SmallIntestine|Mucosa|LowerIleum|Plasma|Volume" id="49" />
+          <Map s="V_pls_lil" id="50" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|Caecum|Plasma|Volume" id="51" />
+          <Map s="V_pls_cae" id="52" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|ColonAscendens|Plasma|Volume" id="53" />
+          <Map s="V_pls_colasc" id="54" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|ColonTransversum|Plasma|Volume" id="55" />
+          <Map s="V_pls_coltrans" id="56" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|ColonDescendens|Plasma|Volume" id="57" />
+          <Map s="V_pls_coldesc" id="58" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|ColonSigmoid|Plasma|Volume" id="59" />
+          <Map s="V_pls_colsigm" id="60" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|Rectum|Plasma|Volume" id="61" />
+          <Map s="V_pls_rect" id="62" />
+          <Map s="Sim|Organism|Liver|Periportal|Plasma|Volume" id="63" />
+          <Map s="V_pls_prp" id="64" />
+          <Map s="Sim|Organism|Liver|Pericentral|Plasma|Volume" id="65" />
+          <Map s="V_pls_prc" id="66" />
+          <Map s="Sim|Organism|Weight of blood organs" id="67" />
+          <Map s="Weight_blood" id="68" />
+          <Map s="Mass" id="69" />
+          <Map s="Sim|Organism|Weight of tissue organs" id="70" />
+          <Map s="Weight_tissue" id="71" />
+          <Map s="Sim|Organism|VenousBlood|Weight (tissue)" id="72" />
+          <Map s="P_1" id="73" />
+          <Map s="Sim|Organism|ArterialBlood|Weight (tissue)" id="74" />
+          <Map s="P_2" id="75" />
+          <Map s="Sim|Organism|PortalVein|Weight (tissue)" id="76" />
+          <Map s="P_3" id="77" />
+          <Map s="Sim|Organism|Bone|Weight (tissue)" id="78" />
+          <Map s="Sim|Organism|Brain|Weight (tissue)" id="79" />
+          <Map s="Sim|Organism|Fat|Weight (tissue)" id="80" />
+          <Map s="Sim|Organism|Gonads|Weight (tissue)" id="81" />
+          <Map s="P_4" id="82" />
+          <Map s="Sim|Organism|Heart|Weight (tissue)" id="83" />
+          <Map s="P_5" id="84" />
+          <Map s="Sim|Organism|Kidney|Weight (tissue)" id="85" />
+          <Map s="P_6" id="86" />
+          <Map s="Sim|Organism|Stomach|Weight (tissue)" id="87" />
+          <Map s="P_7" id="88" />
+          <Map s="Sim|Organism|SmallIntestine|Weight (tissue)" id="89" />
+          <Map s="P_8" id="90" />
+          <Map s="Sim|Organism|LargeIntestine|Weight (tissue)" id="91" />
+          <Map s="P_9" id="92" />
+          <Map s="Sim|Organism|Liver|Periportal|Weight (tissue)" id="93" />
+          <Map s="P_10" id="94" />
+          <Map s="Sim|Organism|Liver|Pericentral|Weight (tissue)" id="95" />
+          <Map s="P_11" id="96" />
+          <Map s="Sim|Organism|Lung|Weight (tissue)" id="97" />
+          <Map s="P_12" id="98" />
+          <Map s="Sim|Organism|Muscle|Weight (tissue)" id="99" />
+          <Map s="P_13" id="100" />
+          <Map s="Sim|Organism|Pancreas|Weight (tissue)" id="101" />
+          <Map s="P_14" id="102" />
+          <Map s="Sim|Organism|Skin|Weight (tissue)" id="103" />
+          <Map s="P_15" id="104" />
+          <Map s="Sim|Organism|Spleen|Weight (tissue)" id="105" />
+          <Map s="P_16" id="106" />
+          <Map s="..|Age" id="107" />
+          <Map s="Age" id="108" />
+          <Map s="Age in years" id="109" />
+          <Map s="..|Gestational age" id="110" />
+          <Map s="GA" id="111" />
+          <Map s="Age in weeks" id="112" />
+          <Map s="Sim|Organism|Height" id="113" />
+          <Map s="Height" id="114" />
+          <Map s="Length" id="115" />
+          <Map s="Sim|Organism|Weight" id="116" />
+          <Map s="BW" id="117" />
+          <Map s="H" id="118" />
+          <Map s="W" id="119" />
+          <Map s="Mean" id="120" />
+          <Map s="Deviation" id="121" />
+          <Map s="Sim|Organism|ArterialBlood|BloodCells|Aciclovir|Concentration" id="122" />
+          <Map s="C_bc_art" id="123" />
+          <Map s="Concentration (molar)" id="124" />
+          <Map s="Sim|Organism|Bone|BloodCells|Aciclovir|Concentration" id="125" />
+          <Map s="C_bc_bon" id="126" />
+          <Map s="Sim|Organism|Fat|BloodCells|Aciclovir|Concentration" id="127" />
+          <Map s="C_bc_fat" id="128" />
+          <Map s="Sim|Organism|Muscle|BloodCells|Aciclovir|Concentration" id="129" />
+          <Map s="C_bc_mus" id="130" />
+          <Map s="Sim|Organism|Skin|BloodCells|Aciclovir|Concentration" id="131" />
+          <Map s="C_bc_skn" id="132" />
+          <Map s="Sim|Organism|ArterialBlood|Peripheral blood flow fraction" id="133" />
+          <Map s="fQ_art" id="134" />
+          <Map s="Fraction" id="135" />
+          <Map s="Sim|Organism|Bone|Peripheral blood flow fraction" id="136" />
+          <Map s="fQ_bon" id="137" />
+          <Map s="Sim|Organism|Fat|Peripheral blood flow fraction" id="138" />
+          <Map s="fQ_fat" id="139" />
+          <Map s="Sim|Organism|Muscle|Peripheral blood flow fraction" id="140" />
+          <Map s="fQ_mus" id="141" />
+          <Map s="Sim|Organism|Skin|Peripheral blood flow fraction" id="142" />
+          <Map s="fQ_skn" id="143" />
+          <Map s="Sim|Organism|ArterialBlood|Plasma|Aciclovir|Concentration" id="144" />
+          <Map s="C_pls_art" id="145" />
+          <Map s="Sim|Organism|Bone|Plasma|Aciclovir|Concentration" id="146" />
+          <Map s="C_pls_bon" id="147" />
+          <Map s="Sim|Organism|Fat|Plasma|Aciclovir|Concentration" id="148" />
+          <Map s="C_pls_fat" id="149" />
+          <Map s="Sim|Organism|Muscle|Plasma|Aciclovir|Concentration" id="150" />
+          <Map s="C_pls_mus" id="151" />
+          <Map s="Sim|Organism|Skin|Plasma|Aciclovir|Concentration" id="152" />
+          <Map s="C_pls_skn" id="153" />
+          <Map s="Sim|Aciclovir|Fraction unbound (plasma)" id="154" />
+          <Map s="fu" id="155" />
+          <Map s="Sim|Organism|Hematocrit" id="156" />
+          <Map s="HCT" id="157" />
+          <Map s="..|Density (tissue)" id="158" />
+          <Map s="Density" id="159" />
+          <Map s="..|Volume" id="160" />
+          <Map s="..|..|Fraction vascular" id="161" />
+          <Map s="f_vas" id="162" />
+          <Map s="..|..|Volume" id="163" />
+          <Map s="V" id="164" />
+          <Map s="..|t1/2" id="165" />
+          <Map s="tHalf" id="166" />
+          <Map s="Time" id="167" />
+          <Map s="Sim|CYP344|Relative expression in plasma" id="168" />
+          <Map s="rel_exp_pls" id="169" />
+          <Map s="Sim|CYP344|Relative expression in plasma (normalized)" id="170" />
+          <Map s="rel_exp_pls_norm" id="171" />
+          <Map s="..|Relative expression (normalized)" id="172" />
+          <Map s="rel_exp_norm" id="173" />
+          <Map s="..|Ontogeny factor" id="174" />
+          <Map s="f_onto" id="175" />
+          <Map s="..|Relative expression out." id="176" />
+          <Map s="rel_exp_out" id="177" />
+          <Map s="Sim|CYP344|Reference concentration" id="178" />
+          <Map s="AF" id="179" />
+          <Map s="..|..|Volume of protein container" id="180" />
+          <Map s="ProteinContainerVolume" id="181" />
+          <Map s=".." id="182" />
+          <Map s="M" id="183" />
+          <Map s="Amount" id="184" />
+          <Map s="Sim|CYP344|Ontogeny factor" id="185" />
+          <Map s="Sim|CYP344|t1/2 (liver)" id="186" />
+          <Map s="Start amount" id="187" />
+          <Map s="M_0" id="188" />
+          <Map s="..|Concentration" id="189" />
+          <Map s="C_pls" id="190" />
+          <Map s="Sim|CYP344|Relative expression in blood cells" id="191" />
+          <Map s="rel_exp_bc" id="192" />
+          <Map s="Sim|CYP344|Relative expression in blood cells (normalized)" id="193" />
+          <Map s="rel_exp_bc_norm" id="194" />
+          <Map s="Sim|Aciclovir|Partition coefficient (blood cells/plasma)" id="195" />
+          <Map s="K_rbc" id="196" />
+          <Map s="..|..|BloodCells|Aciclovir|Concentration" id="197" />
+          <Map s="C_bc" id="198" />
+          <Map s="..|..|Plasma|Aciclovir|Concentration" id="199" />
+          <Map s="..|Specific blood flow rate" id="200" />
+          <Map s="Qspec" id="201" />
+          <Map s="Flow per weight organ" id="202" />
+          <Map s="..|Weight (tissue)" id="203" />
+          <Map s="Weight" id="204" />
+          <Map s="..|Flow fraction via large pores" id="205" />
+          <Map s="alpha_l" id="206" />
+          <Map s="..|Fluid recirculation flow proportionality factor" id="207" />
+          <Map s="f_Jiso" id="208" />
+          <Map s="..|Lymph flow rate" id="209" />
+          <Map s="Q_lymph" id="210" />
+          <Map s="Flow" id="211" />
+          <Map s="..|Organ volume mouse" id="212" />
+          <Map s="V_mouse" id="213" />
+          <Map s="Sim|Organism|Scaling exponent for fluid recirculation flow rate" id="214" />
+          <Map s="exp_Jiso_scale" id="215" />
+          <Map s="..|Blood flow rate" id="216" />
+          <Map s="Q" id="217" />
+          <Map s="..|Lymph flow proportionality factor" id="218" />
+          <Map s="f_lymph" id="219" />
+          <Map s="Sim|Organism|Thickness (endothelium)" id="220" />
+          <Map s="d_endo" id="221" />
+          <Map s="Sim|Neighborhoods|Bone_pls_Bone_int|Surface area (plasma/interstitial)" id="222" />
+          <Map s="SA_pls_int" id="223" />
+          <Map s="Area" id="224" />
+          <Map s="..|Fraction interstitial" id="225" />
+          <Map s="f_int" id="226" />
+          <Map s="..|Fraction vascular" id="227" />
+          <Map s="V_org" id="228" />
+          <Map s="..|..|Fraction interstitial" id="229" />
+          <Map s="Sim|Organism|pH (interstitial)" id="230" />
+          <Map s="pH_int" id="231" />
+          <Map s="Sim|Neighborhoods|Bone_int_Bone_cell|Aciclovir|Partition coefficient (interstitial/water)" id="232" />
+          <Map s="K_water_int" id="233" />
+          <Map s="..|..|Fraction intracellular" id="234" />
+          <Map s="f_cell" id="235" />
+          <Map s="Sim|Neighborhoods|Bone_int_Bone_cell|Aciclovir|Partition coefficient (intracellular/water)" id="236" />
+          <Map s="K_water_cell" id="237" />
+          <Map s="..|..|Interstitial|Aciclovir|Concentration" id="238" />
+          <Map s="C_int" id="239" />
+          <Map s="..|..|Interstitial|Aciclovir|Partition coefficient (water/container)" id="240" />
+          <Map s="..|..|Intracellular|Aciclovir|Concentration" id="241" />
+          <Map s="C_cell" id="242" />
+          <Map s="..|..|Intracellular|Aciclovir|Partition coefficient (water/container)" id="243" />
+          <Map s="..|Gallbladder ejection half-time" id="244" />
+          <Map s="EHC_HalfTime" id="245" />
+          <Map s="Sim|Aciclovir|Total drug mass" id="246" />
+          <Map s="TotalDrugMass" id="247" />
+          <Map s="Sim|Neighborhoods|Brain_pls_Brain_int|Surface area (plasma/interstitial)" id="248" />
+          <Map s="Sim|Neighborhoods|Brain_int_Brain_cell|Aciclovir|Partition coefficient (interstitial/water)" id="249" />
+          <Map s="Sim|Neighborhoods|Brain_int_Brain_cell|Aciclovir|Partition coefficient (intracellular/water)" id="250" />
+          <Map s="Sim|Neighborhoods|Fat_pls_Fat_int|Surface area (plasma/interstitial)" id="251" />
+          <Map s="GeometricDeviation" id="252" />
+          <Map s="Sim|Neighborhoods|Fat_int_Fat_cell|Aciclovir|Partition coefficient (interstitial/water)" id="253" />
+          <Map s="Sim|Neighborhoods|Fat_int_Fat_cell|Aciclovir|Partition coefficient (intracellular/water)" id="254" />
+          <Map s="Sim|Neighborhoods|Gonads_pls_Gonads_int|Surface area (plasma/interstitial)" id="255" />
+          <Map s="Sim|Neighborhoods|Gonads_int_Gonads_cell|Aciclovir|Partition coefficient (interstitial/water)" id="256" />
+          <Map s="Sim|Neighborhoods|Gonads_int_Gonads_cell|Aciclovir|Partition coefficient (intracellular/water)" id="257" />
+          <Map s="Sim|Neighborhoods|Heart_pls_Heart_int|Surface area (plasma/interstitial)" id="258" />
+          <Map s="Sim|Neighborhoods|Heart_int_Heart_cell|Aciclovir|Partition coefficient (interstitial/water)" id="259" />
+          <Map s="Sim|Neighborhoods|Heart_int_Heart_cell|Aciclovir|Partition coefficient (intracellular/water)" id="260" />
+          <Map s="Sim|Neighborhoods|Kidney_pls_Kidney_int|Surface area (plasma/interstitial)" id="261" />
+          <Map s="Sim|Organism|Kidney|GFR (specific)" id="262" />
+          <Map s="GFRspec" id="263" />
+          <Map s="Weight_Kidney" id="264" />
+          <Map s="Sim|Organism|Estimated gestational age" id="265" />
+          <Map s="PMA" id="266" />
+          <Map s="Sim|Organism|Kidney|GFRmat" id="267" />
+          <Map s="GFR_mat" id="268" />
+          <Map s="Sim|Organism|Kidney|Hill coefficient for GFR" id="269" />
+          <Map s="Hill" id="270" />
+          <Map s="Sim|Organism|Kidney|Renal aging scaling factor" id="271" />
+          <Map s="Renal_aging_scaling_factor" id="272" />
+          <Map s="Sim|Organism|Kidney|TM50 for GFR" id="273" />
+          <Map s="TM50" id="274" />
+          <Map s="Sim|Organism|Kidney|Volume (standard kidney)" id="275" />
+          <Map s="V_kid_std" id="276" />
+          <Map s="Sim|Organism|Kidney|fGFRpremat" id="277" />
+          <Map s="GFR_premat" id="278" />
+          <Map s="Sim|Organism|Age" id="279" />
+          <Map s="Sim|Organism|Kidney|Age of aging onset" id="280" />
+          <Map s="Age_onset" id="281" />
+          <Map s="Sim|Organism|Kidney|Aging half-time" id="282" />
+          <Map s="TA50" id="283" />
+          <Map s="Sim|Organism|Kidney|Hill coefficient for aging GFR" id="284" />
+          <Map s="Sim|Organism|Kidney|Maximal decreasing rate factor" id="285" />
+          <Map s="Decrease_Factor" id="286" />
+          <Map s="Sim|Neighborhoods|Kidney_int_Kidney_cell|Aciclovir|Partition coefficient (interstitial/water)" id="287" />
+          <Map s="Sim|Neighborhoods|Kidney_int_Kidney_cell|Aciclovir|Partition coefficient (intracellular/water)" id="288" />
+          <Map s="..|Fraction of geometric volume filled with liquid" id="289" />
+          <Map s="FillLevel" id="290" />
+          <Map s="..|Liquid" id="291" />
+          <Map s="Liquid" id="292" />
+          <Map s="..|Distal radius" id="293" />
+          <Map s="r2" id="294" />
+          <Map s="..|Length" id="295" />
+          <Map s="L" id="296" />
+          <Map s="..|Proximal radius" id="297" />
+          <Map s="r1" id="298" />
+          <Map s="..|Gastric emptying time" id="299" />
+          <Map s="GET" id="300" />
+          <Map s="..|Fractional steady state fill level" id="301" />
+          <Map s="SteadyStateFillLevel" id="302" />
+          <Map s="..|FillLevelFlag" id="303" />
+          <Map s="FillLevelFlag" id="304" />
+          <Map s="..|Liquid transfer rate" id="305" />
+          <Map s="LT_sto" id="306" />
+          <Map s="..|Secretion of liquid" id="307" />
+          <Map s="Inflow" id="308" />
+          <Map s="..|..|OralApplicationsEnabled" id="309" />
+          <Map s="OralApplicationsEnabled" id="310" />
+          <Map s="..|Intestinal transit rate (absolute)" id="311" />
+          <Map s="w" id="312" />
+          <Map s="..|..|Duodenum|FillLevelFlag" id="313" />
+          <Map s="FillLevelFlagNext" id="314" />
+          <Map s="..|pH in fasted state" id="315" />
+          <Map s="pH_fasted" id="316" />
+          <Map s="..|Inverse rate of inflow of liquid into stomach" id="317" />
+          <Map s="StomachInflowTime" id="318" />
+          <Map s="..|Geometric surface area" id="319" />
+          <Map s="..|Thickness of gut wall" id="320" />
+          <Map s="d" id="321" />
+          <Map s="Sim|CYP344|Ontogeny factor GI" id="322" />
+          <Map s="Sim|CYP344|t1/2 (intestine)" id="323" />
+          <Map s="Sim|Aciclovir|CT_NEUTRAL" id="324" />
+          <Map s="CT_NEUTRAL" id="325" />
+          <Map s="Sim|Aciclovir|Compound type 0" id="326" />
+          <Map s="CT0" id="327" />
+          <Map s="Sim|Aciclovir|pKa value 0" id="328" />
+          <Map s="pKa_0" id="329" />
+          <Map s="..|..|pH" id="330" />
+          <Map s="pH" id="331" />
+          <Map s="Sim|Aciclovir|Compound type 1" id="332" />
+          <Map s="CT1" id="333" />
+          <Map s="Sim|Aciclovir|pKa value 1" id="334" />
+          <Map s="pKa_1" id="335" />
+          <Map s="Sim|Aciclovir|Compound type 2" id="336" />
+          <Map s="CT2" id="337" />
+          <Map s="Sim|Aciclovir|pKa value 2" id="338" />
+          <Map s="pKa_2" id="339" />
+          <Map s="..|pKa_pH_WS_lum_F1" id="340" />
+          <Map s="F1" id="341" />
+          <Map s="..|pKa_pH_WS_lum_F2" id="342" />
+          <Map s="F2" id="343" />
+          <Map s="..|pKa_pH_WS_lum_F3" id="344" />
+          <Map s="F3" id="345" />
+          <Map s="..|Solubility table" id="346" />
+          <Map s="SolubilityTable" id="347" />
+          <Map s="Concentration (mass)" id="348" />
+          <Map s="..|Solubility_pKa_pH_Factor" id="349" />
+          <Map s="Solubility_pKa_pH_Factor" id="350" />
+          <Map s="Sim|Aciclovir|Solubility at reference pH" id="351" />
+          <Map s="Solubility" id="352" />
+          <Map s="Sim|Aciclovir|Solubility_pKa_pH_Factor" id="353" />
+          <Map s="Solubility_pKa_REFpH_Factor" id="354" />
+          <Map s="Sim|Aciclovir|Solubility table" id="355" />
+          <Map s="Table" id="356" />
+          <Map s="XArg" id="357" />
+          <Map s="..|pKa_pH_WS_lum_K1" id="358" />
+          <Map s="K1" id="359" />
+          <Map s="..|pKa_pH_WS_lum_K2" id="360" />
+          <Map s="K2" id="361" />
+          <Map s="..|pKa_pH_WS_lum_K3" id="362" />
+          <Map s="K3" id="363" />
+          <Map s="..|pKa_pH_WS_lum_K4" id="364" />
+          <Map s="K4" id="365" />
+          <Map s="..|pKa_pH_WS_lum_K5" id="366" />
+          <Map s="K5" id="367" />
+          <Map s="..|pKa_pH_WS_lum_K6" id="368" />
+          <Map s="K6" id="369" />
+          <Map s="..|pKa_pH_WS_lum_K7" id="370" />
+          <Map s="K7" id="371" />
+          <Map s="..|pKa_pH_WS_lum_K8" id="372" />
+          <Map s="K8" id="373" />
+          <Map s="Sim|Aciclovir|Solubility gain per charge" id="374" />
+          <Map s="base" id="375" />
+          <Map s="..|Solubility" id="376" />
+          <Map s="Sim|Aciclovir|Enable supersaturation" id="377" />
+          <Map s="EnableSupersaturarion" id="378" />
+          <Map s="Sim|Aciclovir|Molecular weight" id="379" />
+          <Map s="MW" id="380" />
+          <Map s="Molecular weight" id="381" />
+          <Map s="..|..|Liquid" id="382" />
+          <Map s="..|Effective concentration in lumen" id="383" />
+          <Map s="EffectiveLumenConcentration" id="384" />
+          <Map s="alpha" id="385" />
+          <Map s="k" id="386" />
+          <Map s="inflow" id="387" />
+          <Map s="..|..|Stomach|Fractional steady state fill level" id="388" />
+          <Map s="alpha_p" id="389" />
+          <Map s="..|..|Stomach|Intestinal transit rate (absolute)" id="390" />
+          <Map s="k_p" id="391" />
+          <Map s="..|..|Stomach|Volume" id="392" />
+          <Map s="V_p" id="393" />
+          <Map s="..|..|..|Height" id="394" />
+          <Map s="..|r2_p0" id="395" />
+          <Map s="r2_p0" id="396" />
+          <Map s="..|r2_p1" id="397" />
+          <Map s="r2_p1" id="398" />
+          <Map s="..|Effective surface area enhancement factor" id="399" />
+          <Map s="AeffFactor" id="400" />
+          <Map s="Ageom" id="401" />
+          <Map s="Sim|Organism|Lumen|Effective surface area variability factor" id="402" />
+          <Map s="AeffVariabilityFactor" id="403" />
+          <Map s="..|Intestinal transit rate" id="404" />
+          <Map s="LuminalVelocity" id="405" />
+          <Map s="Sim|Organism|SmallIntestine|Small intestinal transit time factor" id="406" />
+          <Map s="SITT_fact" id="407" />
+          <Map s="..|L_p0" id="408" />
+          <Map s="L_p0" id="409" />
+          <Map s="..|L_p1" id="410" />
+          <Map s="L_p1" id="411" />
+          <Map s="..|Absorption of liquid" id="412" />
+          <Map s="Outflow" id="413" />
+          <Map s="LT_duo" id="414" />
+          <Map s="..|..|Stomach|Liquid transfer rate" id="415" />
+          <Map s="..|..|UpperJejunum|FillLevelFlag" id="416" />
+          <Map s="..|r1_p0" id="417" />
+          <Map s="r1_p0" id="418" />
+          <Map s="..|r1_p1" id="419" />
+          <Map s="r1_p1" id="420" />
+          <Map s="..|Thickness_p1" id="421" />
+          <Map s="Thickness_p1" id="422" />
+          <Map s="..|Thickness_p2" id="423" />
+          <Map s="Thickness_p2" id="424" />
+          <Map s="..|Thickness_p3" id="425" />
+          <Map s="Thickness_p3" id="426" />
+          <Map s="Inversed length" id="427" />
+          <Map s="Sim|Organism|SmallIntestine|Volume" id="428" />
+          <Map s="V_Intestine" id="429" />
+          <Map s="Sim|Neighborhoods|Lumen_duo_Duodenum_pls|Aciclovir|Sum of active process rates" id="430" />
+          <Map s="ActiveRates_para" id="431" />
+          <Map s="Amount per time" id="432" />
+          <Map s="Sim|Neighborhoods|Lumen_duo_Duodenum_cell|Aciclovir|Sum of active process rates" id="433" />
+          <Map s="ActiveRates_trans" id="434" />
+          <Map s="Sim|Neighborhoods|Lumen_duo_Duodenum_pls|Aciclovir|Sum of passive process rates" id="435" />
+          <Map s="PassiveRates_para" id="436" />
+          <Map s="Sim|Neighborhoods|Lumen_duo_Duodenum_cell|Aciclovir|Sum of passive process rates" id="437" />
+          <Map s="PassiveRates_trans" id="438" />
+          <Map s="..|Oral mass absorbed segment" id="439" />
+          <Map s="MassAbsorbed" id="440" />
+          <Map s="Sim|Aciclovir|Total oral drug mass" id="441" />
+          <Map s="OralDrugMass" id="442" />
+          <Map s="..|..|Duodenum|Fractional steady state fill level" id="443" />
+          <Map s="..|..|Duodenum|Intestinal transit rate (absolute)" id="444" />
+          <Map s="..|..|Duodenum|Volume" id="445" />
+          <Map s="LT_uje" id="446" />
+          <Map s="..|..|Duodenum|Liquid transfer rate" id="447" />
+          <Map s="..|..|LowerJejunum|FillLevelFlag" id="448" />
+          <Map s="Sim|Neighborhoods|Lumen_uje_UpperJejunum_pls|Aciclovir|Sum of active process rates" id="449" />
+          <Map s="Sim|Neighborhoods|Lumen_uje_UpperJejunum_cell|Aciclovir|Sum of active process rates" id="450" />
+          <Map s="Sim|Neighborhoods|Lumen_uje_UpperJejunum_pls|Aciclovir|Sum of passive process rates" id="451" />
+          <Map s="Sim|Neighborhoods|Lumen_uje_UpperJejunum_cell|Aciclovir|Sum of passive process rates" id="452" />
+          <Map s="..|..|UpperJejunum|Fractional steady state fill level" id="453" />
+          <Map s="..|..|UpperJejunum|Intestinal transit rate (absolute)" id="454" />
+          <Map s="..|..|UpperJejunum|Volume" id="455" />
+          <Map s="LT_lje" id="456" />
+          <Map s="..|..|UpperJejunum|Liquid transfer rate" id="457" />
+          <Map s="..|..|UpperIleum|FillLevelFlag" id="458" />
+          <Map s="Sim|Neighborhoods|Lumen_lje_LowerJejunum_pls|Aciclovir|Sum of active process rates" id="459" />
+          <Map s="Sim|Neighborhoods|Lumen_lje_LowerJejunum_cell|Aciclovir|Sum of active process rates" id="460" />
+          <Map s="Sim|Neighborhoods|Lumen_lje_LowerJejunum_pls|Aciclovir|Sum of passive process rates" id="461" />
+          <Map s="Sim|Neighborhoods|Lumen_lje_LowerJejunum_cell|Aciclovir|Sum of passive process rates" id="462" />
+          <Map s="..|..|LowerJejunum|Fractional steady state fill level" id="463" />
+          <Map s="..|..|LowerJejunum|Intestinal transit rate (absolute)" id="464" />
+          <Map s="..|..|LowerJejunum|Volume" id="465" />
+          <Map s="LT_uil" id="466" />
+          <Map s="..|..|LowerJejunum|Liquid transfer rate" id="467" />
+          <Map s="..|..|LowerIleum|FillLevelFlag" id="468" />
+          <Map s="Sim|Neighborhoods|Lumen_uil_UpperIleum_pls|Aciclovir|Sum of active process rates" id="469" />
+          <Map s="Sim|Neighborhoods|Lumen_uil_UpperIleum_cell|Aciclovir|Sum of active process rates" id="470" />
+          <Map s="Sim|Neighborhoods|Lumen_uil_UpperIleum_pls|Aciclovir|Sum of passive process rates" id="471" />
+          <Map s="Sim|Neighborhoods|Lumen_uil_UpperIleum_cell|Aciclovir|Sum of passive process rates" id="472" />
+          <Map s="..|..|UpperIleum|Fractional steady state fill level" id="473" />
+          <Map s="..|..|UpperIleum|Intestinal transit rate (absolute)" id="474" />
+          <Map s="..|..|UpperIleum|Volume" id="475" />
+          <Map s="LT_lil" id="476" />
+          <Map s="..|..|UpperIleum|Liquid transfer rate" id="477" />
+          <Map s="..|..|Caecum|FillLevelFlag" id="478" />
+          <Map s="Sim|Neighborhoods|Lumen_lil_LowerIleum_pls|Aciclovir|Sum of active process rates" id="479" />
+          <Map s="Sim|Neighborhoods|Lumen_lil_LowerIleum_cell|Aciclovir|Sum of active process rates" id="480" />
+          <Map s="Sim|Neighborhoods|Lumen_lil_LowerIleum_pls|Aciclovir|Sum of passive process rates" id="481" />
+          <Map s="Sim|Neighborhoods|Lumen_lil_LowerIleum_cell|Aciclovir|Sum of passive process rates" id="482" />
+          <Map s="..|..|LowerIleum|Fractional steady state fill level" id="483" />
+          <Map s="..|..|LowerIleum|Intestinal transit rate (absolute)" id="484" />
+          <Map s="..|..|LowerIleum|Volume" id="485" />
+          <Map s="Sim|Organism|LargeIntestine|Large intestinal transit time factor" id="486" />
+          <Map s="LITT_fact" id="487" />
+          <Map s="LT_cae" id="488" />
+          <Map s="..|..|LowerIleum|Liquid transfer rate" id="489" />
+          <Map s="..|..|ColonAscendens|FillLevelFlag" id="490" />
+          <Map s="Sim|Organism|LargeIntestine|Volume" id="491" />
+          <Map s="Sim|Neighborhoods|Lumen_cae_Caecum_pls|Aciclovir|Sum of active process rates" id="492" />
+          <Map s="Sim|Neighborhoods|Lumen_cae_Caecum_cell|Aciclovir|Sum of active process rates" id="493" />
+          <Map s="Sim|Neighborhoods|Lumen_cae_Caecum_pls|Aciclovir|Sum of passive process rates" id="494" />
+          <Map s="Sim|Neighborhoods|Lumen_cae_Caecum_cell|Aciclovir|Sum of passive process rates" id="495" />
+          <Map s="..|..|Caecum|Fractional steady state fill level" id="496" />
+          <Map s="..|..|Caecum|Intestinal transit rate (absolute)" id="497" />
+          <Map s="..|..|Caecum|Volume" id="498" />
+          <Map s="LT_colasc" id="499" />
+          <Map s="..|..|Caecum|Liquid transfer rate" id="500" />
+          <Map s="..|..|ColonTransversum|FillLevelFlag" id="501" />
+          <Map s="Sim|Neighborhoods|Lumen_colasc_ColonAscendens_pls|Aciclovir|Sum of active process rates" id="502" />
+          <Map s="Sim|Neighborhoods|Lumen_colasc_ColonAscendens_cell|Aciclovir|Sum of active process rates" id="503" />
+          <Map s="Sim|Neighborhoods|Lumen_colasc_ColonAscendens_pls|Aciclovir|Sum of passive process rates" id="504" />
+          <Map s="Sim|Neighborhoods|Lumen_colasc_ColonAscendens_cell|Aciclovir|Sum of passive process rates" id="505" />
+          <Map s="..|..|ColonAscendens|Fractional steady state fill level" id="506" />
+          <Map s="..|..|ColonAscendens|Intestinal transit rate (absolute)" id="507" />
+          <Map s="..|..|ColonAscendens|Volume" id="508" />
+          <Map s="LT_coltrans" id="509" />
+          <Map s="..|..|ColonAscendens|Liquid transfer rate" id="510" />
+          <Map s="..|..|ColonDescendens|FillLevelFlag" id="511" />
+          <Map s="Sim|Neighborhoods|Lumen_coltrans_ColonTransversum_pls|Aciclovir|Sum of active process rates" id="512" />
+          <Map s="Sim|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|Aciclovir|Sum of active process rates" id="513" />
+          <Map s="Sim|Neighborhoods|Lumen_coltrans_ColonTransversum_pls|Aciclovir|Sum of passive process rates" id="514" />
+          <Map s="Sim|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|Aciclovir|Sum of passive process rates" id="515" />
+          <Map s="..|..|ColonTransversum|Fractional steady state fill level" id="516" />
+          <Map s="..|..|ColonTransversum|Intestinal transit rate (absolute)" id="517" />
+          <Map s="..|..|ColonTransversum|Volume" id="518" />
+          <Map s="LT_coldesc" id="519" />
+          <Map s="..|..|ColonTransversum|Liquid transfer rate" id="520" />
+          <Map s="..|..|ColonSigmoid|FillLevelFlag" id="521" />
+          <Map s="Sim|Neighborhoods|Lumen_coldesc_ColonDescendens_pls|Aciclovir|Sum of active process rates" id="522" />
+          <Map s="Sim|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|Aciclovir|Sum of active process rates" id="523" />
+          <Map s="Sim|Neighborhoods|Lumen_coldesc_ColonDescendens_pls|Aciclovir|Sum of passive process rates" id="524" />
+          <Map s="Sim|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|Aciclovir|Sum of passive process rates" id="525" />
+          <Map s="..|..|ColonDescendens|Fractional steady state fill level" id="526" />
+          <Map s="..|..|ColonDescendens|Intestinal transit rate (absolute)" id="527" />
+          <Map s="..|..|ColonDescendens|Volume" id="528" />
+          <Map s="LT_colsigm" id="529" />
+          <Map s="..|..|ColonDescendens|Liquid transfer rate" id="530" />
+          <Map s="..|..|Rectum|FillLevelFlag" id="531" />
+          <Map s="Sim|Neighborhoods|Lumen_colsigm_ColonSigmoid_pls|Aciclovir|Sum of active process rates" id="532" />
+          <Map s="Sim|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|Aciclovir|Sum of active process rates" id="533" />
+          <Map s="Sim|Neighborhoods|Lumen_colsigm_ColonSigmoid_pls|Aciclovir|Sum of passive process rates" id="534" />
+          <Map s="Sim|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|Aciclovir|Sum of passive process rates" id="535" />
+          <Map s="..|..|ColonSigmoid|Fractional steady state fill level" id="536" />
+          <Map s="..|..|ColonSigmoid|Intestinal transit rate (absolute)" id="537" />
+          <Map s="..|..|ColonSigmoid|Volume" id="538" />
+          <Map s="LT_rect" id="539" />
+          <Map s="..|..|ColonSigmoid|Liquid transfer rate" id="540" />
+          <Map s="Sim|Neighborhoods|Lumen_rect_Rectum_pls|Aciclovir|Sum of active process rates" id="541" />
+          <Map s="Sim|Neighborhoods|Lumen_rect_Rectum_cell|Aciclovir|Sum of active process rates" id="542" />
+          <Map s="Sim|Neighborhoods|Lumen_rect_Rectum_pls|Aciclovir|Sum of passive process rates" id="543" />
+          <Map s="Sim|Neighborhoods|Lumen_rect_Rectum_cell|Aciclovir|Sum of passive process rates" id="544" />
+          <Map s="..|..|Rectum|Liquid transfer rate" id="545" />
+          <Map s="LT_rec" id="546" />
+          <Map s="Sim|Organism|Lumen|Caecum|Aciclovir" id="547" />
+          <Map s="M_cae" id="548" />
+          <Map s="Sim|Organism|Lumen|ColonAscendens|Aciclovir" id="549" />
+          <Map s="M_colasc" id="550" />
+          <Map s="Sim|Organism|Lumen|ColonDescendens|Aciclovir" id="551" />
+          <Map s="M_coldesc" id="552" />
+          <Map s="Sim|Organism|Lumen|ColonSigmoid|Aciclovir" id="553" />
+          <Map s="M_colsigm" id="554" />
+          <Map s="Sim|Organism|Lumen|ColonTransversum|Aciclovir" id="555" />
+          <Map s="M_coltrans" id="556" />
+          <Map s="Sim|Organism|Lumen|Duodenum|Aciclovir" id="557" />
+          <Map s="M_duo" id="558" />
+          <Map s="Sim|Organism|Lumen|Feces|Aciclovir" id="559" />
+          <Map s="M_fec" id="560" />
+          <Map s="Sim|Organism|Lumen|LowerIleum|Aciclovir" id="561" />
+          <Map s="M_lil" id="562" />
+          <Map s="Sim|Organism|Lumen|LowerJejunum|Aciclovir" id="563" />
+          <Map s="M_lje" id="564" />
+          <Map s="Sim|Organism|Lumen|Rectum|Aciclovir" id="565" />
+          <Map s="M_rect" id="566" />
+          <Map s="Sim|Organism|Lumen|Stomach|Aciclovir" id="567" />
+          <Map s="M_sto" id="568" />
+          <Map s="Sim|Organism|Lumen|UpperIleum|Aciclovir" id="569" />
+          <Map s="M_uil" id="570" />
+          <Map s="Sim|Organism|Lumen|UpperJejunum|Aciclovir" id="571" />
+          <Map s="M_uje" id="572" />
+          <Map s="Sim|Neighborhoods|Lumen_sto_Lumen_duo|Aciclovir|Oral mass absorbed" id="573" />
+          <Map s="Mabs_Mucosa" id="574" />
+          <Map s="TotalOralDrugMass" id="575" />
+          <Map s="Sim|Neighborhoods|Stomach_pls_Stomach_int|Surface area (plasma/interstitial)" id="576" />
+          <Map s="Sim|Neighborhoods|Stomach_int_Stomach_cell|Aciclovir|Partition coefficient (interstitial/water)" id="577" />
+          <Map s="Sim|Neighborhoods|Stomach_int_Stomach_cell|Aciclovir|Partition coefficient (intracellular/water)" id="578" />
+          <Map s="..|Small intestinal transit time" id="579" />
+          <Map s="SITT" id="580" />
+          <Map s="..|Small intestinal transit time factor intercept" id="581" />
+          <Map s="P2" id="582" />
+          <Map s="..|Small intestinal transit time factor slope" id="583" />
+          <Map s="P1" id="584" />
+          <Map s="..|Fluid recirculation flow rate (incl. mucosa)" id="585" />
+          <Map s="J_iso_incl_Mucosa" id="586" />
+          <Map s="..|Mucosa|Duodenum|Fluid recirculation flow rate" id="587" />
+          <Map s="J_iso_duo" id="588" />
+          <Map s="..|Mucosa|LowerIleum|Fluid recirculation flow rate" id="589" />
+          <Map s="J_iso_lil" id="590" />
+          <Map s="..|Mucosa|LowerJejunum|Fluid recirculation flow rate" id="591" />
+          <Map s="J_iso_lje" id="592" />
+          <Map s="..|Mucosa|UpperIleum|Fluid recirculation flow rate" id="593" />
+          <Map s="J_iso_uil" id="594" />
+          <Map s="..|Mucosa|UpperJejunum|Fluid recirculation flow rate" id="595" />
+          <Map s="J_iso_uje" id="596" />
+          <Map s="..|Lymph flow rate (incl. mucosa)" id="597" />
+          <Map s="Q_lymph_incl_Mucosa" id="598" />
+          <Map s="..|Mucosa|Duodenum|Lymph flow rate" id="599" />
+          <Map s="Q_lymph_duo" id="600" />
+          <Map s="..|Mucosa|LowerIleum|Lymph flow rate" id="601" />
+          <Map s="Q_lymph_lil" id="602" />
+          <Map s="..|Mucosa|LowerJejunum|Lymph flow rate" id="603" />
+          <Map s="Q_lymph_lje" id="604" />
+          <Map s="..|Mucosa|UpperIleum|Lymph flow rate" id="605" />
+          <Map s="Q_lymph_uil" id="606" />
+          <Map s="..|Mucosa|UpperJejunum|Lymph flow rate" id="607" />
+          <Map s="Q_lymph_uje" id="608" />
+          <Map s="Sim|Neighborhoods|SmallIntestine_pls_SmallIntestine_int|Surface area (plasma/interstitial)" id="609" />
+          <Map s="..|Mucosa|Duodenum|Volume" id="610" />
+          <Map s="V_duo" id="611" />
+          <Map s="..|Mucosa|LowerIleum|Volume" id="612" />
+          <Map s="V_lil" id="613" />
+          <Map s="..|Mucosa|LowerJejunum|Volume" id="614" />
+          <Map s="V_lje" id="615" />
+          <Map s="..|Mucosa|UpperIleum|Volume" id="616" />
+          <Map s="V_uil" id="617" />
+          <Map s="..|Mucosa|UpperJejunum|Volume" id="618" />
+          <Map s="V_uje" id="619" />
+          <Map s="..|..|Volume (mucosa)" id="620" />
+          <Map s="V_Mucosa" id="621" />
+          <Map s="Sim|Neighborhoods|SmallIntestine_int_SmallIntestine_cell|Aciclovir|Partition coefficient (interstitial/water)" id="622" />
+          <Map s="Sim|Neighborhoods|SmallIntestine_int_SmallIntestine_cell|Aciclovir|Partition coefficient (intracellular/water)" id="623" />
+          <Map s="..|Fraction mucosa" id="624" />
+          <Map s="fractionMucosa" id="625" />
+          <Map s="..|..|..|..|Lumen|Duodenum|Volume (gut wall)" id="626" />
+          <Map s="V_GutWall" id="627" />
+          <Map s="..|..|..|Fluid recirculation flow rate (incl. mucosa)" id="628" />
+          <Map s="J_iso_intestine" id="629" />
+          <Map s="..|..|..|Volume" id="630" />
+          <Map s="V_intestine" id="631" />
+          <Map s="V_seg" id="632" />
+          <Map s="..|..|..|Lymph flow rate (incl. mucosa)" id="633" />
+          <Map s="Q_lymph_intestine" id="634" />
+          <Map s="Sim|Neighborhoods|Duodenum_pls_Duodenum_int|Surface area (plasma/interstitial)" id="635" />
+          <Map s="..|..|..|Blood flow rate" id="636" />
+          <Map s="..|Fraction of regional blood flow rate" id="637" />
+          <Map s="regionalFractQ" id="638" />
+          <Map s="..|..|..|Mucosa blood flow fraction" id="639" />
+          <Map s="fractQ" id="640" />
+          <Map s="Sim|Neighborhoods|Duodenum_int_Duodenum_cell|Aciclovir|Partition coefficient (interstitial/water)" id="641" />
+          <Map s="Sim|Neighborhoods|Duodenum_int_Duodenum_cell|Aciclovir|Partition coefficient (intracellular/water)" id="642" />
+          <Map s="..|..|..|..|Lumen|UpperJejunum|Volume (gut wall)" id="643" />
+          <Map s="Sim|Neighborhoods|UpperJejunum_pls_UpperJejunum_int|Surface area (plasma/interstitial)" id="644" />
+          <Map s="Sim|Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Aciclovir|Partition coefficient (interstitial/water)" id="645" />
+          <Map s="Sim|Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Aciclovir|Partition coefficient (intracellular/water)" id="646" />
+          <Map s="..|..|..|..|Lumen|LowerJejunum|Volume (gut wall)" id="647" />
+          <Map s="Sim|Neighborhoods|LowerJejunum_pls_LowerJejunum_int|Surface area (plasma/interstitial)" id="648" />
+          <Map s="Sim|Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Aciclovir|Partition coefficient (interstitial/water)" id="649" />
+          <Map s="Sim|Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Aciclovir|Partition coefficient (intracellular/water)" id="650" />
+          <Map s="..|..|..|..|Lumen|UpperIleum|Volume (gut wall)" id="651" />
+          <Map s="Sim|Neighborhoods|UpperIleum_pls_UpperIleum_int|Surface area (plasma/interstitial)" id="652" />
+          <Map s="Sim|Neighborhoods|UpperIleum_int_UpperIleum_cell|Aciclovir|Partition coefficient (interstitial/water)" id="653" />
+          <Map s="Sim|Neighborhoods|UpperIleum_int_UpperIleum_cell|Aciclovir|Partition coefficient (intracellular/water)" id="654" />
+          <Map s="..|..|..|..|Lumen|LowerIleum|Volume (gut wall)" id="655" />
+          <Map s="Sim|Neighborhoods|LowerIleum_pls_LowerIleum_int|Surface area (plasma/interstitial)" id="656" />
+          <Map s="Sim|Neighborhoods|LowerIleum_int_LowerIleum_cell|Aciclovir|Partition coefficient (interstitial/water)" id="657" />
+          <Map s="Sim|Neighborhoods|LowerIleum_int_LowerIleum_cell|Aciclovir|Partition coefficient (intracellular/water)" id="658" />
+          <Map s="Sim|Organism|SmallIntestine|Interstitial|Volume" id="659" />
+          <Map s="V_int" id="660" />
+          <Map s="Sim|Organism|SmallIntestine|Mucosa|Duodenum|Interstitial|Volume" id="661" />
+          <Map s="V_int_duo" id="662" />
+          <Map s="Sim|Organism|SmallIntestine|Mucosa|LowerIleum|Interstitial|Volume" id="663" />
+          <Map s="V_int_lil" id="664" />
+          <Map s="Sim|Organism|SmallIntestine|Mucosa|LowerJejunum|Interstitial|Volume" id="665" />
+          <Map s="V_int_lje" id="666" />
+          <Map s="Sim|Organism|SmallIntestine|Mucosa|UpperIleum|Interstitial|Volume" id="667" />
+          <Map s="V_int_uil" id="668" />
+          <Map s="Sim|Organism|SmallIntestine|Mucosa|UpperJejunum|Interstitial|Volume" id="669" />
+          <Map s="V_int_uje" id="670" />
+          <Map s="Sim|Organism|SmallIntestine|Intracellular|Volume" id="671" />
+          <Map s="V_cell" id="672" />
+          <Map s="Sim|Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|Volume" id="673" />
+          <Map s="V_cell_duo" id="674" />
+          <Map s="Sim|Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|Volume" id="675" />
+          <Map s="V_cell_lil" id="676" />
+          <Map s="Sim|Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|Volume" id="677" />
+          <Map s="V_cell_lje" id="678" />
+          <Map s="Sim|Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|Volume" id="679" />
+          <Map s="V_cell_uil" id="680" />
+          <Map s="Sim|Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|Volume" id="681" />
+          <Map s="V_cell_uje" id="682" />
+          <Map s="Sim|Organism|SmallIntestine|Intracellular|Aciclovir" id="683" />
+          <Map s="M_cell" id="684" />
+          <Map s="Sim|Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|Aciclovir" id="685" />
+          <Map s="M_cell_duo" id="686" />
+          <Map s="Sim|Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|Aciclovir" id="687" />
+          <Map s="M_cell_lil" id="688" />
+          <Map s="Sim|Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|Aciclovir" id="689" />
+          <Map s="M_cell_lje" id="690" />
+          <Map s="Sim|Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|Aciclovir" id="691" />
+          <Map s="M_cell_uil" id="692" />
+          <Map s="Sim|Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|Aciclovir" id="693" />
+          <Map s="M_cell_uje" id="694" />
+          <Map s="Sim|Organism|SmallIntestine|Interstitial|Aciclovir" id="695" />
+          <Map s="M_int" id="696" />
+          <Map s="Sim|Organism|SmallIntestine|Mucosa|Duodenum|Interstitial|Aciclovir" id="697" />
+          <Map s="M_int_duo" id="698" />
+          <Map s="Sim|Organism|SmallIntestine|Mucosa|LowerIleum|Interstitial|Aciclovir" id="699" />
+          <Map s="M_int_lil" id="700" />
+          <Map s="Sim|Organism|SmallIntestine|Mucosa|LowerJejunum|Interstitial|Aciclovir" id="701" />
+          <Map s="M_int_lje" id="702" />
+          <Map s="Sim|Organism|SmallIntestine|Mucosa|UpperIleum|Interstitial|Aciclovir" id="703" />
+          <Map s="M_int_uil" id="704" />
+          <Map s="Sim|Organism|SmallIntestine|Mucosa|UpperJejunum|Interstitial|Aciclovir" id="705" />
+          <Map s="M_int_uje" id="706" />
+          <Map s="..|Large intestinal transit time" id="707" />
+          <Map s="LITT" id="708" />
+          <Map s="..|Large intestinal transit time factor intercept" id="709" />
+          <Map s="..|Large intestinal transit time factor slope" id="710" />
+          <Map s="..|Mucosa|Caecum|Volume" id="711" />
+          <Map s="V_cae" id="712" />
+          <Map s="..|Mucosa|ColonAscendens|Volume" id="713" />
+          <Map s="V_ca" id="714" />
+          <Map s="..|Mucosa|ColonDescendens|Volume" id="715" />
+          <Map s="V_cd" id="716" />
+          <Map s="..|Mucosa|ColonSigmoid|Volume" id="717" />
+          <Map s="V_cs" id="718" />
+          <Map s="..|Mucosa|ColonTransversum|Volume" id="719" />
+          <Map s="V_ct" id="720" />
+          <Map s="..|Mucosa|Rectum|Volume" id="721" />
+          <Map s="V_rec" id="722" />
+          <Map s="..|Mucosa|Caecum|Fluid recirculation flow rate" id="723" />
+          <Map s="J_iso_cae" id="724" />
+          <Map s="..|Mucosa|ColonAscendens|Fluid recirculation flow rate" id="725" />
+          <Map s="J_iso_colasc" id="726" />
+          <Map s="..|Mucosa|ColonDescendens|Fluid recirculation flow rate" id="727" />
+          <Map s="J_iso_coldesc" id="728" />
+          <Map s="..|Mucosa|ColonSigmoid|Fluid recirculation flow rate" id="729" />
+          <Map s="J_iso_colsigm" id="730" />
+          <Map s="..|Mucosa|ColonTransversum|Fluid recirculation flow rate" id="731" />
+          <Map s="J_iso_coltrans" id="732" />
+          <Map s="..|Mucosa|Rectum|Fluid recirculation flow rate" id="733" />
+          <Map s="J_iso_rect" id="734" />
+          <Map s="..|Mucosa|Caecum|Lymph flow rate" id="735" />
+          <Map s="Q_lymph_cae" id="736" />
+          <Map s="..|Mucosa|ColonAscendens|Lymph flow rate" id="737" />
+          <Map s="Q_lymph_colasc" id="738" />
+          <Map s="..|Mucosa|ColonDescendens|Lymph flow rate" id="739" />
+          <Map s="Q_lymph_coldesc" id="740" />
+          <Map s="..|Mucosa|ColonSigmoid|Lymph flow rate" id="741" />
+          <Map s="Q_lymph_colsigm" id="742" />
+          <Map s="..|Mucosa|ColonTransversum|Lymph flow rate" id="743" />
+          <Map s="Q_lymph_coltrans" id="744" />
+          <Map s="..|Mucosa|Rectum|Lymph flow rate" id="745" />
+          <Map s="Q_lymph_rect" id="746" />
+          <Map s="Sim|Neighborhoods|LargeIntestine_pls_LargeIntestine_int|Surface area (plasma/interstitial)" id="747" />
+          <Map s="Sim|Neighborhoods|LargeIntestine_int_LargeIntestine_cell|Aciclovir|Partition coefficient (interstitial/water)" id="748" />
+          <Map s="Sim|Neighborhoods|LargeIntestine_int_LargeIntestine_cell|Aciclovir|Partition coefficient (intracellular/water)" id="749" />
+          <Map s="..|..|..|..|Lumen|Caecum|Volume (gut wall)" id="750" />
+          <Map s="Sim|Neighborhoods|Caecum_pls_Caecum_int|Surface area (plasma/interstitial)" id="751" />
+          <Map s="Sim|Neighborhoods|Caecum_int_Caecum_cell|Aciclovir|Partition coefficient (interstitial/water)" id="752" />
+          <Map s="Sim|Neighborhoods|Caecum_int_Caecum_cell|Aciclovir|Partition coefficient (intracellular/water)" id="753" />
+          <Map s="..|..|..|..|Lumen|ColonAscendens|Volume (gut wall)" id="754" />
+          <Map s="Sim|Neighborhoods|ColonAscendens_pls_ColonAscendens_int|Surface area (plasma/interstitial)" id="755" />
+          <Map s="Sim|Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Aciclovir|Partition coefficient (interstitial/water)" id="756" />
+          <Map s="Sim|Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Aciclovir|Partition coefficient (intracellular/water)" id="757" />
+          <Map s="..|..|..|..|Lumen|ColonTransversum|Volume (gut wall)" id="758" />
+          <Map s="Sim|Neighborhoods|ColonTransversum_pls_ColonTransversum_int|Surface area (plasma/interstitial)" id="759" />
+          <Map s="Sim|Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Aciclovir|Partition coefficient (interstitial/water)" id="760" />
+          <Map s="Sim|Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Aciclovir|Partition coefficient (intracellular/water)" id="761" />
+          <Map s="..|..|..|..|Lumen|ColonDescendens|Volume (gut wall)" id="762" />
+          <Map s="Sim|Neighborhoods|ColonDescendens_pls_ColonDescendens_int|Surface area (plasma/interstitial)" id="763" />
+          <Map s="Sim|Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Aciclovir|Partition coefficient (interstitial/water)" id="764" />
+          <Map s="Sim|Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Aciclovir|Partition coefficient (intracellular/water)" id="765" />
+          <Map s="..|..|..|..|Lumen|ColonSigmoid|Volume (gut wall)" id="766" />
+          <Map s="Sim|Neighborhoods|ColonSigmoid_pls_ColonSigmoid_int|Surface area (plasma/interstitial)" id="767" />
+          <Map s="Sim|Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Aciclovir|Partition coefficient (interstitial/water)" id="768" />
+          <Map s="Sim|Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Aciclovir|Partition coefficient (intracellular/water)" id="769" />
+          <Map s="..|..|..|..|Lumen|Rectum|Volume (gut wall)" id="770" />
+          <Map s="Sim|Neighborhoods|Rectum_pls_Rectum_int|Surface area (plasma/interstitial)" id="771" />
+          <Map s="Sim|Neighborhoods|Rectum_int_Rectum_cell|Aciclovir|Partition coefficient (interstitial/water)" id="772" />
+          <Map s="Sim|Neighborhoods|Rectum_int_Rectum_cell|Aciclovir|Partition coefficient (intracellular/water)" id="773" />
+          <Map s="Sim|Organism|LargeIntestine|Interstitial|Volume" id="774" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|Caecum|Interstitial|Volume" id="775" />
+          <Map s="V_int_cae" id="776" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|ColonAscendens|Interstitial|Volume" id="777" />
+          <Map s="V_int_colasc" id="778" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|ColonDescendens|Interstitial|Volume" id="779" />
+          <Map s="V_int_coldesc" id="780" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|ColonSigmoid|Interstitial|Volume" id="781" />
+          <Map s="V_int_colsigm" id="782" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|ColonTransversum|Interstitial|Volume" id="783" />
+          <Map s="V_int_coltrans" id="784" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|Rectum|Interstitial|Volume" id="785" />
+          <Map s="V_int_rect" id="786" />
+          <Map s="Sim|Organism|LargeIntestine|Intracellular|Volume" id="787" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|Caecum|Intracellular|Volume" id="788" />
+          <Map s="V_cell_cae" id="789" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|Volume" id="790" />
+          <Map s="V_cell_colasc" id="791" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|Volume" id="792" />
+          <Map s="V_cell_coldesc" id="793" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|Volume" id="794" />
+          <Map s="V_cell_colsigm" id="795" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|Volume" id="796" />
+          <Map s="V_cell_coltrans" id="797" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|Rectum|Intracellular|Volume" id="798" />
+          <Map s="V_cell_rect" id="799" />
+          <Map s="Sim|Organism|LargeIntestine|Intracellular|Aciclovir" id="800" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|Caecum|Intracellular|Aciclovir" id="801" />
+          <Map s="M_cell_cae" id="802" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|Aciclovir" id="803" />
+          <Map s="M_cell_colasc" id="804" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|Aciclovir" id="805" />
+          <Map s="M_cell_coldesc" id="806" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|Aciclovir" id="807" />
+          <Map s="M_cell_colsigm" id="808" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|Aciclovir" id="809" />
+          <Map s="M_cell_coltrans" id="810" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|Rectum|Intracellular|Aciclovir" id="811" />
+          <Map s="M_cell_rect" id="812" />
+          <Map s="Sim|Organism|LargeIntestine|Interstitial|Aciclovir" id="813" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|Caecum|Interstitial|Aciclovir" id="814" />
+          <Map s="M_int_cae" id="815" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|ColonAscendens|Interstitial|Aciclovir" id="816" />
+          <Map s="M_int_colasc" id="817" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|ColonDescendens|Interstitial|Aciclovir" id="818" />
+          <Map s="M_int_coldesc" id="819" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|ColonSigmoid|Interstitial|Aciclovir" id="820" />
+          <Map s="M_int_colsigm" id="821" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|ColonTransversum|Interstitial|Aciclovir" id="822" />
+          <Map s="M_int_coltrans" id="823" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|Rectum|Interstitial|Aciclovir" id="824" />
+          <Map s="M_int_rect" id="825" />
+          <Map s="Sim|Neighborhoods|Liver_pls_Liver_int|Surface area (plasma/interstitial)" id="826" />
+          <Map s="..|..|Allometric scale factor" id="827" />
+          <Map s="Liver_Parameter" id="828" />
+          <Map s="..|..|Density (tissue)" id="829" />
+          <Map s="..|..|Fraction of blood for sampling" id="830" />
+          <Map s="Sim|Organism|Liver|Fraction of periportal zone" id="831" />
+          <Map s="f_periportal" id="832" />
+          <Map s="Sim|Organism|Liver|Is liver zonated" id="833" />
+          <Map s="IsLiverZonated" id="834" />
+          <Map s="Sim|Organism|Liver|Volume" id="835" />
+          <Map s="V_liv" id="836" />
+          <Map s="..|..|Flow fraction via large pores" id="837" />
+          <Map s="..|..|Fluid recirculation flow rate" id="838" />
+          <Map s="J_iso" id="839" />
+          <Map s="..|..|Hydraulic conductivity" id="840" />
+          <Map s="Hydraulic conductivity" id="841" />
+          <Map s="..|..|Lymph flow rate" id="842" />
+          <Map s="..|..|Radius (large pores)" id="843" />
+          <Map s="..|..|Radius (small pores)" id="844" />
+          <Map s="Sim|Neighborhoods|Periportal_pls_Periportal_int|Surface area (plasma/interstitial)" id="845" />
+          <Map s="..|..|Vf (lipid)" id="846" />
+          <Map s="..|..|Vf (neutral lipid)-PT" id="847" />
+          <Map s="..|..|Vf (phospholipid)-PT" id="848" />
+          <Map s="..|..|Vf (protein)" id="849" />
+          <Map s="..|..|Albumin ratio (tissue/plasma)" id="850" />
+          <Map s="..|..|Albumin ratio (tissue/plasma)-PT" id="851" />
+          <Map s="..|..|Lipoprotein ratio (tissue/plasma)" id="852" />
+          <Map s="..|..|Microsomal protein mass/g tissue" id="853" />
+          <Map s="Mass per tissue" id="854" />
+          <Map s="..|..|Number of cells/g tissue" id="855" />
+          <Map s="Count per mass" id="856" />
+          <Map s="..|..|Vf (water)" id="857" />
+          <Map s="..|..|Vf (water)-PT" id="858" />
+          <Map s="..|..|Vf (neutral lipid)-RR" id="859" />
+          <Map s="..|..|Vf (neutral lipid)-WS" id="860" />
+          <Map s="..|..|Vf (neutral phospholipid)-RR" id="861" />
+          <Map s="..|..|Vf (neutral phospholipid, plasma)-WS" id="862" />
+          <Map s="..|..|Vf (extracellular water)-RR" id="863" />
+          <Map s="..|..|Vf (protein)-WS" id="864" />
+          <Map s="..|..|Vf (intracellular water)-RR" id="865" />
+          <Map s="..|..|Vf (water)-WS" id="866" />
+          <Map s="..|..|Acidic phospholipids [mg/g] - RR" id="867" />
+          <Map s="..|..|Vf (acidic phospholipids)-WS" id="868" />
+          <Map s="..|..|Specific blood flow rate" id="869" />
+          <Map s="..|..|Blood flow rate" id="870" />
+          <Map s="Sim|Neighborhoods|Periportal_int_Periportal_cell|Aciclovir|Partition coefficient (interstitial/water)" id="871" />
+          <Map s="Sim|Organism|Liver|Intracellular|pH" id="872" />
+          <Map s="pH_cell_Liver" id="873" />
+          <Map s="Sim|Neighborhoods|Periportal_int_Periportal_cell|Aciclovir|Partition coefficient (intracellular/water)" id="874" />
+          <Map s="Sim|Neighborhoods|Pericentral_pls_Pericentral_int|Surface area (plasma/interstitial)" id="875" />
+          <Map s="Sim|Organism|Liver|Pericentral|Plasma|Aciclovir|Concentration" id="876" />
+          <Map s="C_pls_prc" id="877" />
+          <Map s="Sim|Organism|Liver|Periportal|Plasma|Aciclovir|Concentration" id="878" />
+          <Map s="C_pls_prp" id="879" />
+          <Map s="Sim|Organism|Liver|Pericentral|BloodCells|Volume" id="880" />
+          <Map s="V_bc_prc" id="881" />
+          <Map s="Sim|Organism|Liver|Periportal|BloodCells|Volume" id="882" />
+          <Map s="V_bc_prp" id="883" />
+          <Map s="Sim|Organism|Liver|Pericentral|BloodCells|Aciclovir|Concentration" id="884" />
+          <Map s="C_bc_prc" id="885" />
+          <Map s="Sim|Organism|Liver|Periportal|BloodCells|Aciclovir|Concentration" id="886" />
+          <Map s="C_bc_prp" id="887" />
+          <Map s="Sim|Organism|Liver|Pericentral|Interstitial|Volume" id="888" />
+          <Map s="V_int_prc" id="889" />
+          <Map s="Sim|Organism|Liver|Periportal|Interstitial|Volume" id="890" />
+          <Map s="V_int_prp" id="891" />
+          <Map s="Sim|Organism|Liver|Pericentral|Interstitial|Aciclovir|Concentration" id="892" />
+          <Map s="C_int_prc" id="893" />
+          <Map s="Sim|Organism|Liver|Periportal|Interstitial|Aciclovir|Concentration" id="894" />
+          <Map s="C_int_prp" id="895" />
+          <Map s="Sim|Organism|Liver|Pericentral|Intracellular|Volume" id="896" />
+          <Map s="V_cell_prc" id="897" />
+          <Map s="Sim|Organism|Liver|Periportal|Intracellular|Volume" id="898" />
+          <Map s="V_cell_prp" id="899" />
+          <Map s="Sim|Organism|Liver|Pericentral|Intracellular|Aciclovir|Concentration" id="900" />
+          <Map s="C_cell_prc" id="901" />
+          <Map s="Sim|Organism|Liver|Periportal|Intracellular|Aciclovir|Concentration" id="902" />
+          <Map s="C_cell_prp" id="903" />
+          <Map s="Sim|Organism|Liver|Pericentral|Interstitial|Aciclovir|Partition coefficient (water/container)" id="904" />
+          <Map s="K_water_int_prc" id="905" />
+          <Map s="Sim|Organism|Liver|Periportal|Interstitial|Aciclovir|Partition coefficient (water/container)" id="906" />
+          <Map s="K_water_int_prp" id="907" />
+          <Map s="Sim|Organism|Liver|Pericentral|Intracellular|Aciclovir|Partition coefficient (water/container)" id="908" />
+          <Map s="K_water_cell_prc" id="909" />
+          <Map s="Sim|Organism|Liver|Periportal|Intracellular|Aciclovir|Partition coefficient (water/container)" id="910" />
+          <Map s="K_water_cell_prp" id="911" />
+          <Map s="Sim|Neighborhoods|Lung_pls_Lung_int|Surface area (plasma/interstitial)" id="912" />
+          <Map s="Sim|Organism|Bone|Blood flow rate" id="913" />
+          <Map s="Q_bon" id="914" />
+          <Map s="Sim|Organism|Brain|Blood flow rate" id="915" />
+          <Map s="Q_brn" id="916" />
+          <Map s="Sim|Organism|Fat|Blood flow rate" id="917" />
+          <Map s="Q_fat" id="918" />
+          <Map s="Sim|Organism|Gonads|Blood flow rate" id="919" />
+          <Map s="Q_tes" id="920" />
+          <Map s="Sim|Organism|Heart|Blood flow rate" id="921" />
+          <Map s="Q_hrt" id="922" />
+          <Map s="Sim|Organism|Kidney|Blood flow rate" id="923" />
+          <Map s="Q_kid" id="924" />
+          <Map s="Sim|Organism|LargeIntestine|Blood flow rate" id="925" />
+          <Map s="Q_lin" id="926" />
+          <Map s="Sim|Organism|Liver|Blood flow rate" id="927" />
+          <Map s="Q_liv" id="928" />
+          <Map s="Sim|Organism|Muscle|Blood flow rate" id="929" />
+          <Map s="Q_mus" id="930" />
+          <Map s="Sim|Organism|Pancreas|Blood flow rate" id="931" />
+          <Map s="Q_pan" id="932" />
+          <Map s="Sim|Organism|Skin|Blood flow rate" id="933" />
+          <Map s="Q_skn" id="934" />
+          <Map s="Sim|Organism|SmallIntestine|Blood flow rate" id="935" />
+          <Map s="Q_sin" id="936" />
+          <Map s="Sim|Organism|Spleen|Blood flow rate" id="937" />
+          <Map s="Q_spl" id="938" />
+          <Map s="Sim|Organism|Stomach|Blood flow rate" id="939" />
+          <Map s="Q_sto" id="940" />
+          <Map s="Sim|Neighborhoods|Lung_int_Lung_cell|Aciclovir|Partition coefficient (interstitial/water)" id="941" />
+          <Map s="Sim|Neighborhoods|Lung_int_Lung_cell|Aciclovir|Partition coefficient (intracellular/water)" id="942" />
+          <Map s="Sim|Neighborhoods|Muscle_pls_Muscle_int|Surface area (plasma/interstitial)" id="943" />
+          <Map s="Sim|Neighborhoods|Muscle_int_Muscle_cell|Aciclovir|Partition coefficient (interstitial/water)" id="944" />
+          <Map s="Sim|Neighborhoods|Muscle_int_Muscle_cell|Aciclovir|Partition coefficient (intracellular/water)" id="945" />
+          <Map s="Sim|Neighborhoods|Pancreas_pls_Pancreas_int|Surface area (plasma/interstitial)" id="946" />
+          <Map s="Sim|Neighborhoods|Pancreas_int_Pancreas_cell|Aciclovir|Partition coefficient (interstitial/water)" id="947" />
+          <Map s="Sim|Neighborhoods|Pancreas_int_Pancreas_cell|Aciclovir|Partition coefficient (intracellular/water)" id="948" />
+          <Map s="Sim|Organism|LargeIntestine|Lymph flow rate (incl. mucosa)" id="949" />
+          <Map s="Q_Lymph_lin_incl_Mucosa" id="950" />
+          <Map s="Sim|Organism|Pancreas|Lymph flow rate" id="951" />
+          <Map s="Q_Lymph_pan" id="952" />
+          <Map s="Sim|Organism|SmallIntestine|Lymph flow rate (incl. mucosa)" id="953" />
+          <Map s="Q_Lymph_sin_incl_Mucosa" id="954" />
+          <Map s="Sim|Organism|Spleen|Lymph flow rate" id="955" />
+          <Map s="Q_Lymph_spl" id="956" />
+          <Map s="Sim|Organism|Stomach|Lymph flow rate" id="957" />
+          <Map s="Q_Lymph_sto" id="958" />
+          <Map s="Sim|Neighborhoods|Skin_pls_Skin_int|Surface area (plasma/interstitial)" id="959" />
+          <Map s="Sim|Neighborhoods|Skin_int_Skin_cell|Aciclovir|Partition coefficient (interstitial/water)" id="960" />
+          <Map s="Sim|Neighborhoods|Skin_int_Skin_cell|Aciclovir|Partition coefficient (intracellular/water)" id="961" />
+          <Map s="Sim|Neighborhoods|Spleen_pls_Spleen_int|Surface area (plasma/interstitial)" id="962" />
+          <Map s="Sim|Neighborhoods|Spleen_int_Spleen_cell|Aciclovir|Partition coefficient (interstitial/water)" id="963" />
+          <Map s="Sim|Neighborhoods|Spleen_int_Spleen_cell|Aciclovir|Partition coefficient (intracellular/water)" id="964" />
+          <Map s="Sim|Organism|Saliva|Volume" id="965" />
+          <Map s="V_slv" id="966" />
+          <Map s="Sim|Organism|Lung|BloodCells|..|Blood flow rate" id="967" />
+          <Map s="Sim|Organism|VenousBlood|BloodCells|Aciclovir|Concentration" id="968" />
+          <Map s="Sim|Organism|Lung|Plasma|..|Blood flow rate" id="969" />
+          <Map s="Sim|Organism|VenousBlood|Plasma|Aciclovir|Concentration" id="970" />
+          <Map s="Sim|Aciclovir|P (blood cells-&gt;plasma)" id="971" />
+          <Map s="P_rbc_pls" id="972" />
+          <Map s="Velocity" id="973" />
+          <Map s="Sim|Aciclovir|P (plasma-&gt;blood cells)" id="974" />
+          <Map s="P_pls_rbc" id="975" />
+          <Map s="Sim|Neighborhoods|VenousBlood_pls_VenousBlood_bc|Surface area (blood cells/plasma)" id="976" />
+          <Map s="SA_bc" id="977" />
+          <Map s="Sim|Organism|VenousBlood|Plasma|..|Volume" id="978" />
+          <Map s="Sim|Organism|Surface/Volume ratio (blood cells)" id="979" />
+          <Map s="A_to_V_bc" id="980" />
+          <Map s="Sim|Neighborhoods|ArterialBlood_pls_ArterialBlood_bc|Surface area (blood cells/plasma)" id="981" />
+          <Map s="Sim|Organism|ArterialBlood|Plasma|..|Volume" id="982" />
+          <Map s="Sim|Organism|Bone|BloodCells|..|Blood flow rate" id="983" />
+          <Map s="..|P_int_cell_factor" id="984" />
+          <Map s="P_int_cell_factor" id="985" />
+          <Map s="Sim|Aciclovir|Permeability" id="986" />
+          <Map s="P" id="987" />
+          <Map s="..|P_cell_int_factor" id="988" />
+          <Map s="P_cell_int_factor" id="989" />
+          <Map s="..|P (interstitial-&gt;intracellular)" id="990" />
+          <Map s="P_int_cell" id="991" />
+          <Map s="..|..|Surface area (interstitial/intracellular)" id="992" />
+          <Map s="SA" id="993" />
+          <Map s="..|P (intracellular-&gt;interstitial)" id="994" />
+          <Map s="P_cell_int" id="995" />
+          <Map s="Sim|Aciclovir|Lipophilicity" id="996" />
+          <Map s="LogMA" id="997" />
+          <Map s="Log Units" id="998" />
+          <Map s="Sim|Aciclovir|Partition coefficient (water/protein)" id="999" />
+          <Map s="KProt" id="1000" />
+          <Map s="Sim|Organism|Bone|Interstitial|..|Vf (lipid)" id="1001" />
+          <Map s="f_lipids" id="1002" />
+          <Map s="Sim|Organism|Bone|Interstitial|..|Vf (protein)" id="1003" />
+          <Map s="f_proteins" id="1004" />
+          <Map s="Sim|Organism|Bone|Interstitial|..|Vf (water)" id="1005" />
+          <Map s="f_water" id="1006" />
+          <Map s="..|Partition coefficient (intracellular/plasma)" id="1007" />
+          <Map s="K_cell_pls" id="1008" />
+          <Map s="Sim|Neighborhoods|Bone_pls_Bone_int|Aciclovir|Partition coefficient (interstitial/plasma)" id="1009" />
+          <Map s="K_int_pls" id="1010" />
+          <Map s="Sim|Organism|Bone|Intracellular|Aciclovir|Concentration" id="1011" />
+          <Map s="Sim|Organism|Bone|Interstitial|Aciclovir|Concentration" id="1012" />
+          <Map s="Sim|Neighborhoods|Bone_int_Bone_cell|Aciclovir|P*SA interstitial -&gt; intracellular" id="1013" />
+          <Map s="PA_int_cell" id="1014" />
+          <Map s="Sim|Neighborhoods|Bone_int_Bone_cell|Aciclovir|P*SA intracellular -&gt; interstitial" id="1015" />
+          <Map s="PA_cell_int" id="1016" />
+          <Map s="Sim|Organism|Bone|Interstitial|..|Volume" id="1017" />
+          <Map s="V_bon" id="1018" />
+          <Map s="Sim|Neighborhoods|Bone_pls_Bone_bc|Surface area (blood cells/plasma)" id="1019" />
+          <Map s="Sim|Organism|Bone|Plasma|..|Fraction vascular" id="1020" />
+          <Map s="Sim|Organism|Bone|Plasma|..|Volume" id="1021" />
+          <Map s="Sim|Organism|Protein ratio (interstial/plasma)" id="1022" />
+          <Map s="f_proteins_int_to_pls" id="1023" />
+          <Map s="Sim|Organism|Vf (water,interstitial)" id="1024" />
+          <Map s="f_water_int" id="1025" />
+          <Map s="Sim|Organism|Vf (water,plasma)" id="1026" />
+          <Map s="f_water_pls" id="1027" />
+          <Map s="Sim|Neighborhoods|Bone_pls_Bone_int|Aciclovir|P (plasma&lt;-&gt;interstitial)" id="1028" />
+          <Map s="P_endothelial" id="1029" />
+          <Map s="f_vas_org" id="1030" />
+          <Map s="Sim|Organism|SA proportionality factor" id="1031" />
+          <Map s="Sim|Organism|Bone|Plasma|..|Blood flow rate" id="1032" />
+          <Map s="Sim|Organism|Brain|BloodCells|..|Blood flow rate" id="1033" />
+          <Map s="Sim|Organism|Brain|BloodCells|Aciclovir|Concentration" id="1034" />
+          <Map s="Sim|Organism|Brain|Interstitial|..|Vf (lipid)" id="1035" />
+          <Map s="Sim|Organism|Brain|Interstitial|..|Vf (protein)" id="1036" />
+          <Map s="Sim|Organism|Brain|Interstitial|..|Vf (water)" id="1037" />
+          <Map s="Sim|Neighborhoods|Brain_pls_Brain_int|Aciclovir|Partition coefficient (interstitial/plasma)" id="1038" />
+          <Map s="Sim|Organism|Brain|Intracellular|Aciclovir|Concentration" id="1039" />
+          <Map s="Sim|Organism|Brain|Interstitial|Aciclovir|Concentration" id="1040" />
+          <Map s="Sim|Neighborhoods|Brain_int_Brain_cell|Aciclovir|P*SA interstitial -&gt; intracellular" id="1041" />
+          <Map s="Sim|Neighborhoods|Brain_int_Brain_cell|Aciclovir|P*SA intracellular -&gt; interstitial" id="1042" />
+          <Map s="Sim|Organism|Brain|Interstitial|..|Volume" id="1043" />
+          <Map s="V_brn" id="1044" />
+          <Map s="Sim|Organism|Brain|Plasma|Aciclovir|Concentration" id="1045" />
+          <Map s="Sim|Neighborhoods|Brain_pls_Brain_bc|Surface area (blood cells/plasma)" id="1046" />
+          <Map s="Sim|Organism|Brain|Plasma|..|Fraction vascular" id="1047" />
+          <Map s="Sim|Organism|Brain|Plasma|..|Volume" id="1048" />
+          <Map s="Sim|Neighborhoods|Brain_pls_Brain_int|Aciclovir|P (plasma&lt;-&gt;interstitial)" id="1049" />
+          <Map s="Sim|Organism|Brain|Plasma|..|Blood flow rate" id="1050" />
+          <Map s="Sim|Organism|Fat|BloodCells|..|Blood flow rate" id="1051" />
+          <Map s="Sim|Organism|Fat|Interstitial|..|Vf (lipid)" id="1052" />
+          <Map s="Sim|Organism|Fat|Interstitial|..|Vf (protein)" id="1053" />
+          <Map s="Sim|Organism|Fat|Interstitial|..|Vf (water)" id="1054" />
+          <Map s="Sim|Neighborhoods|Fat_pls_Fat_int|Aciclovir|Partition coefficient (interstitial/plasma)" id="1055" />
+          <Map s="Sim|Organism|Fat|Intracellular|Aciclovir|Concentration" id="1056" />
+          <Map s="Sim|Organism|Fat|Interstitial|Aciclovir|Concentration" id="1057" />
+          <Map s="Sim|Neighborhoods|Fat_int_Fat_cell|Aciclovir|P*SA interstitial -&gt; intracellular" id="1058" />
+          <Map s="Sim|Neighborhoods|Fat_int_Fat_cell|Aciclovir|P*SA intracellular -&gt; interstitial" id="1059" />
+          <Map s="Sim|Organism|Fat|Interstitial|..|Volume" id="1060" />
+          <Map s="V_fat" id="1061" />
+          <Map s="Sim|Neighborhoods|Fat_pls_Fat_bc|Surface area (blood cells/plasma)" id="1062" />
+          <Map s="Sim|Organism|Fat|Plasma|..|Fraction vascular" id="1063" />
+          <Map s="Sim|Organism|Fat|Plasma|..|Volume" id="1064" />
+          <Map s="Sim|Neighborhoods|Fat_pls_Fat_int|Aciclovir|P (plasma&lt;-&gt;interstitial)" id="1065" />
+          <Map s="Sim|Organism|Fat|Plasma|..|Blood flow rate" id="1066" />
+          <Map s="Sim|Organism|Gonads|BloodCells|..|Blood flow rate" id="1067" />
+          <Map s="Sim|Organism|Gonads|BloodCells|Aciclovir|Concentration" id="1068" />
+          <Map s="Sim|Organism|Gonads|Interstitial|..|Vf (lipid)" id="1069" />
+          <Map s="Sim|Organism|Gonads|Interstitial|..|Vf (protein)" id="1070" />
+          <Map s="Sim|Organism|Gonads|Interstitial|..|Vf (water)" id="1071" />
+          <Map s="Sim|Neighborhoods|Gonads_pls_Gonads_int|Aciclovir|Partition coefficient (interstitial/plasma)" id="1072" />
+          <Map s="Sim|Organism|Gonads|Intracellular|Aciclovir|Concentration" id="1073" />
+          <Map s="Sim|Organism|Gonads|Interstitial|Aciclovir|Concentration" id="1074" />
+          <Map s="Sim|Neighborhoods|Gonads_int_Gonads_cell|Aciclovir|P*SA interstitial -&gt; intracellular" id="1075" />
+          <Map s="Sim|Neighborhoods|Gonads_int_Gonads_cell|Aciclovir|P*SA intracellular -&gt; interstitial" id="1076" />
+          <Map s="Sim|Organism|Gonads|Interstitial|..|Volume" id="1077" />
+          <Map s="V_tes" id="1078" />
+          <Map s="Sim|Organism|Gonads|Plasma|Aciclovir|Concentration" id="1079" />
+          <Map s="Sim|Neighborhoods|Gonads_pls_Gonads_bc|Surface area (blood cells/plasma)" id="1080" />
+          <Map s="Sim|Organism|Gonads|Plasma|..|Fraction vascular" id="1081" />
+          <Map s="Sim|Organism|Gonads|Plasma|..|Volume" id="1082" />
+          <Map s="Sim|Neighborhoods|Gonads_pls_Gonads_int|Aciclovir|P (plasma&lt;-&gt;interstitial)" id="1083" />
+          <Map s="Sim|Organism|Gonads|Plasma|..|Blood flow rate" id="1084" />
+          <Map s="Sim|Organism|Heart|BloodCells|..|Blood flow rate" id="1085" />
+          <Map s="Sim|Organism|Heart|BloodCells|Aciclovir|Concentration" id="1086" />
+          <Map s="Sim|Organism|Heart|Interstitial|..|Vf (lipid)" id="1087" />
+          <Map s="Sim|Organism|Heart|Interstitial|..|Vf (protein)" id="1088" />
+          <Map s="Sim|Organism|Heart|Interstitial|..|Vf (water)" id="1089" />
+          <Map s="Sim|Neighborhoods|Heart_pls_Heart_int|Aciclovir|Partition coefficient (interstitial/plasma)" id="1090" />
+          <Map s="Sim|Organism|Heart|Intracellular|Aciclovir|Concentration" id="1091" />
+          <Map s="Sim|Organism|Heart|Interstitial|Aciclovir|Concentration" id="1092" />
+          <Map s="Sim|Neighborhoods|Heart_int_Heart_cell|Aciclovir|P*SA interstitial -&gt; intracellular" id="1093" />
+          <Map s="Sim|Neighborhoods|Heart_int_Heart_cell|Aciclovir|P*SA intracellular -&gt; interstitial" id="1094" />
+          <Map s="Sim|Organism|Heart|Interstitial|..|Volume" id="1095" />
+          <Map s="V_hrt" id="1096" />
+          <Map s="Sim|Organism|Heart|Plasma|Aciclovir|Concentration" id="1097" />
+          <Map s="Sim|Neighborhoods|Heart_pls_Heart_bc|Surface area (blood cells/plasma)" id="1098" />
+          <Map s="Sim|Organism|Heart|Plasma|..|Fraction vascular" id="1099" />
+          <Map s="Sim|Organism|Heart|Plasma|..|Volume" id="1100" />
+          <Map s="Sim|Neighborhoods|Heart_pls_Heart_int|Aciclovir|P (plasma&lt;-&gt;interstitial)" id="1101" />
+          <Map s="Sim|Organism|Heart|Plasma|..|Blood flow rate" id="1102" />
+          <Map s="Sim|Organism|Kidney|BloodCells|..|Blood flow rate" id="1103" />
+          <Map s="Sim|Organism|Kidney|BloodCells|Aciclovir|Concentration" id="1104" />
+          <Map s="Sim|Organism|Kidney|Interstitial|..|Vf (lipid)" id="1105" />
+          <Map s="Sim|Organism|Kidney|Interstitial|..|Vf (protein)" id="1106" />
+          <Map s="Sim|Organism|Kidney|Interstitial|..|Vf (water)" id="1107" />
+          <Map s="Sim|Neighborhoods|Kidney_pls_Kidney_int|Aciclovir|Partition coefficient (interstitial/plasma)" id="1108" />
+          <Map s="Sim|Organism|Kidney|Intracellular|Aciclovir|Concentration" id="1109" />
+          <Map s="Sim|Organism|Kidney|Interstitial|Aciclovir|Concentration" id="1110" />
+          <Map s="Sim|Neighborhoods|Kidney_int_Kidney_cell|Aciclovir|P*SA interstitial -&gt; intracellular" id="1111" />
+          <Map s="Sim|Neighborhoods|Kidney_int_Kidney_cell|Aciclovir|P*SA intracellular -&gt; interstitial" id="1112" />
+          <Map s="Sim|Organism|Kidney|Interstitial|..|Volume" id="1113" />
+          <Map s="V_kid" id="1114" />
+          <Map s="Sim|Organism|Kidney|Plasma|Aciclovir|Concentration" id="1115" />
+          <Map s="Sim|Neighborhoods|Kidney_pls_Kidney_bc|Surface area (blood cells/plasma)" id="1116" />
+          <Map s="Sim|Organism|Kidney|Plasma|..|Fraction vascular" id="1117" />
+          <Map s="Sim|Organism|Kidney|Plasma|..|Volume" id="1118" />
+          <Map s="Sim|Neighborhoods|Kidney_pls_Kidney_int|Aciclovir|P (plasma&lt;-&gt;interstitial)" id="1119" />
+          <Map s="..|Tubular secretion" id="1120" />
+          <Map s="TS" id="1121" />
+          <Map s="..|Volume (kidney)" id="1122" />
+          <Map s="C_kid_pls" id="1123" />
+          <Map s="TSspec" id="1124" />
+          <Map s="Sim|Organism|Kidney|Plasma|..|GFR (specific)" id="1125" />
+          <Map s="Sim|Organism|Kidney|Plasma|..|Weight (tissue)" id="1126" />
+          <Map s="GFR fraction" id="1127" />
+          <Map s="GFR_Fraction" id="1128" />
+          <Map s="Sim|Organism|Kidney|Plasma|..|Blood flow rate" id="1129" />
+          <Map s="Sim|Organism|Lumen|UpperJejunum|Effective surface area" id="1130" />
+          <Map s="Aeff" id="1131" />
+          <Map s="Sim|Organism|SmallIntestine|Mucosa|UpperJejunum|Plasma|Aciclovir|Concentration" id="1132" />
+          <Map s="DrugMucosa" id="1133" />
+          <Map s="Sim|Organism|Lumen|UpperJejunum|Aciclovir|Effective concentration in lumen" id="1134" />
+          <Map s="Sim|Aciclovir|Intestinal permeability (paracellular)" id="1135" />
+          <Map s="P_int_para" id="1136" />
+          <Map s="Sim|Organism|Lumen|UpperJejunum|..|OralApplicationsEnabled" id="1137" />
+          <Map s="Sim|Organism|Lumen|UpperJejunum|..|Paracellular absorption sink condition" id="1138" />
+          <Map s="SinkCondition_para" id="1139" />
+          <Map s="Sim|Neighborhoods|Lumen_uje_UpperJejunum_pls|Aciclovir|DrugAbsorption_para|ProcessRate" id="1140" />
+          <Map s="Sim|Neighborhoods|Lumen_uje_UpperJejunum_pls|Aciclovir|Drug absorption rate (lumen to mucosa)" id="1141" />
+          <Map s="DrugAbsorptionLumenToMucosaRate" id="1142" />
+          <Map s="Sim|Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|Aciclovir|Concentration" id="1143" />
+          <Map s="Sim|Aciclovir|Intestinal permeability (transcellular)" id="1144" />
+          <Map s="P_int_trans" id="1145" />
+          <Map s="Sim|Neighborhoods|Lumen_uje_UpperJejunum_cell|Aciclovir|P_int_trans_cell_lum_factor" id="1146" />
+          <Map s="P_int_trans_cell_lum_factor" id="1147" />
+          <Map s="Sim|Neighborhoods|Lumen_uje_UpperJejunum_cell|Aciclovir|P_int_trans_lum_cell_factor" id="1148" />
+          <Map s="P_int_trans_lum_cell_factor" id="1149" />
+          <Map s="Sim|Organism|Lumen|UpperJejunum|..|Transcellular absorption sink condition" id="1150" />
+          <Map s="SinkCondition_trans" id="1151" />
+          <Map s="..|pKa_pH_WS_cell_K1" id="1152" />
+          <Map s="..|pKa_pH_WS_cell_K2" id="1153" />
+          <Map s="..|pKa_pH_WS_cell_K3" id="1154" />
+          <Map s="..|pKa_pH_WS_cell_K4" id="1155" />
+          <Map s="..|pKa_pH_WS_cell_K5" id="1156" />
+          <Map s="..|pKa_pH_WS_cell_K6" id="1157" />
+          <Map s="..|pKa_pH_WS_cell_K7" id="1158" />
+          <Map s="..|pKa_pH_WS_cell_K8" id="1159" />
+          <Map s="Sim|Aciclovir|Use pH- and pKa-dependent penalty factor for charged molecule fraction" id="1160" />
+          <Map s="UsePenaltyFactor" id="1161" />
+          <Map s="Sim|Aciclovir|base_For_Pint_Factor" id="1162" />
+          <Map s="Sim|Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Aciclovir|Partition coefficient (intracellular/plasma)" id="1163" />
+          <Map s="Sim|Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|pH" id="1164" />
+          <Map s="..|pKa_pH_WS_cell_F1" id="1165" />
+          <Map s="..|pKa_pH_WS_cell_F2" id="1166" />
+          <Map s="..|pKa_pH_WS_cell_F3" id="1167" />
+          <Map s="Sim|Organism|Lumen|UpperJejunum|pH" id="1168" />
+          <Map s="Sim|Neighborhoods|Lumen_uje_UpperJejunum_cell|Aciclovir|DrugAbsorption_trans|ProcessRate" id="1169" />
+          <Map s="Sim|Neighborhoods|Lumen_uje_UpperJejunum_cell|Aciclovir|Drug absorption rate (lumen to mucosa)" id="1170" />
+          <Map s="Sim|Organism|SmallIntestine|Mucosa|UpperJejunum|Plasma|..|Blood flow rate" id="1171" />
+          <Map s="Sim|Neighborhoods|UpperJejunum_pls_PortalVein_pls|Aciclovir|Mass transfer rate (mucosa to portal vein plasma)" id="1172" />
+          <Map s="MassTransferMucosaToPvePlasmaRate" id="1173" />
+          <Map s="Sim|Organism|SmallIntestine|Mucosa|UpperJejunum|BloodCells|Aciclovir|Concentration" id="1174" />
+          <Map s="Sim|Organism|SmallIntestine|Mucosa|UpperJejunum|BloodCells|..|Blood flow rate" id="1175" />
+          <Map s="Sim|Neighborhoods|UpperJejunum_bc_PortalVein_bc|Aciclovir|Mass transfer rate (mucosa to portal vein blood cells)" id="1176" />
+          <Map s="MassTransferMucosaToPveBCRate" id="1177" />
+          <Map s="Sim|Organism|Lumen|LowerJejunum|Effective surface area" id="1178" />
+          <Map s="Sim|Organism|SmallIntestine|Mucosa|LowerJejunum|Plasma|Aciclovir|Concentration" id="1179" />
+          <Map s="Sim|Organism|Lumen|LowerJejunum|Aciclovir|Effective concentration in lumen" id="1180" />
+          <Map s="Sim|Organism|Lumen|LowerJejunum|..|OralApplicationsEnabled" id="1181" />
+          <Map s="Sim|Organism|Lumen|LowerJejunum|..|Paracellular absorption sink condition" id="1182" />
+          <Map s="Sim|Neighborhoods|Lumen_lje_LowerJejunum_pls|Aciclovir|DrugAbsorption_para|ProcessRate" id="1183" />
+          <Map s="Sim|Neighborhoods|Lumen_lje_LowerJejunum_pls|Aciclovir|Drug absorption rate (lumen to mucosa)" id="1184" />
+          <Map s="Sim|Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|Aciclovir|Concentration" id="1185" />
+          <Map s="Sim|Neighborhoods|Lumen_lje_LowerJejunum_cell|Aciclovir|P_int_trans_cell_lum_factor" id="1186" />
+          <Map s="Sim|Neighborhoods|Lumen_lje_LowerJejunum_cell|Aciclovir|P_int_trans_lum_cell_factor" id="1187" />
+          <Map s="Sim|Organism|Lumen|LowerJejunum|..|Transcellular absorption sink condition" id="1188" />
+          <Map s="Sim|Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Aciclovir|Partition coefficient (intracellular/plasma)" id="1189" />
+          <Map s="Sim|Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|pH" id="1190" />
+          <Map s="Sim|Organism|Lumen|LowerJejunum|pH" id="1191" />
+          <Map s="Sim|Neighborhoods|Lumen_lje_LowerJejunum_cell|Aciclovir|DrugAbsorption_trans|ProcessRate" id="1192" />
+          <Map s="Sim|Neighborhoods|Lumen_lje_LowerJejunum_cell|Aciclovir|Drug absorption rate (lumen to mucosa)" id="1193" />
+          <Map s="Sim|Organism|SmallIntestine|Mucosa|LowerJejunum|Plasma|..|Blood flow rate" id="1194" />
+          <Map s="Sim|Neighborhoods|LowerJejunum_pls_PortalVein_pls|Aciclovir|Mass transfer rate (mucosa to portal vein plasma)" id="1195" />
+          <Map s="Sim|Organism|SmallIntestine|Mucosa|LowerJejunum|BloodCells|Aciclovir|Concentration" id="1196" />
+          <Map s="Sim|Organism|SmallIntestine|Mucosa|LowerJejunum|BloodCells|..|Blood flow rate" id="1197" />
+          <Map s="Sim|Neighborhoods|LowerJejunum_bc_PortalVein_bc|Aciclovir|Mass transfer rate (mucosa to portal vein blood cells)" id="1198" />
+          <Map s="Sim|Organism|Lumen|Caecum|Aciclovir|Oral mass absorbed segment" id="1199" />
+          <Map s="MAbs_cae" id="1200" />
+          <Map s="Sim|Organism|Lumen|ColonAscendens|Aciclovir|Oral mass absorbed segment" id="1201" />
+          <Map s="MAbs_colasc" id="1202" />
+          <Map s="Sim|Organism|Lumen|ColonDescendens|Aciclovir|Oral mass absorbed segment" id="1203" />
+          <Map s="MAbs_coldesc" id="1204" />
+          <Map s="Sim|Organism|Lumen|ColonSigmoid|Aciclovir|Oral mass absorbed segment" id="1205" />
+          <Map s="MAbs_colsigm" id="1206" />
+          <Map s="Sim|Organism|Lumen|ColonTransversum|Aciclovir|Oral mass absorbed segment" id="1207" />
+          <Map s="MAbs_coltrans" id="1208" />
+          <Map s="Sim|Organism|Lumen|Duodenum|Aciclovir|Oral mass absorbed segment" id="1209" />
+          <Map s="MAbs_duo" id="1210" />
+          <Map s="Sim|Organism|Lumen|LowerIleum|Aciclovir|Oral mass absorbed segment" id="1211" />
+          <Map s="MAbs_lil" id="1212" />
+          <Map s="Sim|Organism|Lumen|LowerJejunum|Aciclovir|Oral mass absorbed segment" id="1213" />
+          <Map s="MAbs_lje" id="1214" />
+          <Map s="Sim|Organism|Lumen|Rectum|Aciclovir|Oral mass absorbed segment" id="1215" />
+          <Map s="MAbs_rect" id="1216" />
+          <Map s="Sim|Organism|Lumen|UpperIleum|Aciclovir|Oral mass absorbed segment" id="1217" />
+          <Map s="MAbs_uil" id="1218" />
+          <Map s="Sim|Organism|Lumen|UpperJejunum|Aciclovir|Oral mass absorbed segment" id="1219" />
+          <Map s="MAbs_uje" id="1220" />
+          <Map s="Sim|Organism|Lumen|Stomach|..|OralApplicationsEnabled" id="1221" />
+          <Map s="Drug" id="1222" />
+          <Map s="Sim|Aciclovir|Is floating in lumen" id="1223" />
+          <Map s="IsFloatingInLumen" id="1224" />
+          <Map s="Sim|Organism|Lumen|Stomach|Intestinal transit rate (absolute)" id="1225" />
+          <Map s="Sim|Organism|Lumen|Duodenum|FillLevelFlag" id="1226" />
+          <Map s="Sim|Organism|Lumen|Duodenum|..|OralApplicationsEnabled" id="1227" />
+          <Map s="Sim|Organism|Lumen|Duodenum|Intestinal transit rate (absolute)" id="1228" />
+          <Map s="Sim|Organism|Lumen|UpperJejunum|FillLevelFlag" id="1229" />
+          <Map s="Sim|Organism|Lumen|UpperJejunum|Intestinal transit rate (absolute)" id="1230" />
+          <Map s="Sim|Organism|Lumen|LowerJejunum|FillLevelFlag" id="1231" />
+          <Map s="Sim|Organism|Lumen|LowerJejunum|Intestinal transit rate (absolute)" id="1232" />
+          <Map s="Sim|Organism|Lumen|UpperIleum|FillLevelFlag" id="1233" />
+          <Map s="Sim|Organism|Lumen|UpperIleum|..|OralApplicationsEnabled" id="1234" />
+          <Map s="Sim|Organism|Lumen|UpperIleum|Intestinal transit rate (absolute)" id="1235" />
+          <Map s="Sim|Organism|Lumen|LowerIleum|FillLevelFlag" id="1236" />
+          <Map s="Sim|Organism|Lumen|LowerIleum|..|OralApplicationsEnabled" id="1237" />
+          <Map s="Sim|Organism|Lumen|LowerIleum|Intestinal transit rate (absolute)" id="1238" />
+          <Map s="Sim|Organism|Lumen|Caecum|FillLevelFlag" id="1239" />
+          <Map s="Sim|Organism|Lumen|Caecum|..|OralApplicationsEnabled" id="1240" />
+          <Map s="Sim|Organism|Lumen|Caecum|Intestinal transit rate (absolute)" id="1241" />
+          <Map s="Sim|Organism|Lumen|ColonAscendens|FillLevelFlag" id="1242" />
+          <Map s="Sim|Organism|Lumen|ColonAscendens|..|OralApplicationsEnabled" id="1243" />
+          <Map s="Sim|Organism|Lumen|ColonAscendens|Intestinal transit rate (absolute)" id="1244" />
+          <Map s="Sim|Organism|Lumen|ColonTransversum|FillLevelFlag" id="1245" />
+          <Map s="Sim|Organism|Lumen|ColonTransversum|..|OralApplicationsEnabled" id="1246" />
+          <Map s="Sim|Organism|Lumen|ColonTransversum|Intestinal transit rate (absolute)" id="1247" />
+          <Map s="Sim|Organism|Lumen|ColonDescendens|FillLevelFlag" id="1248" />
+          <Map s="Sim|Organism|Lumen|ColonDescendens|..|OralApplicationsEnabled" id="1249" />
+          <Map s="Sim|Organism|Lumen|ColonDescendens|Intestinal transit rate (absolute)" id="1250" />
+          <Map s="Sim|Organism|Lumen|ColonSigmoid|FillLevelFlag" id="1251" />
+          <Map s="Sim|Organism|Lumen|ColonSigmoid|..|OralApplicationsEnabled" id="1252" />
+          <Map s="Sim|Organism|Lumen|ColonSigmoid|Intestinal transit rate (absolute)" id="1253" />
+          <Map s="Sim|Organism|Lumen|Rectum|FillLevelFlag" id="1254" />
+          <Map s="Sim|Organism|Lumen|Rectum|..|OralApplicationsEnabled" id="1255" />
+          <Map s="Sim|Organism|Lumen|Rectum|Intestinal transit rate (absolute)" id="1256" />
+          <Map s="Sim|Organism|Stomach|BloodCells|..|Blood flow rate" id="1257" />
+          <Map s="Sim|Organism|Stomach|BloodCells|Aciclovir|Concentration" id="1258" />
+          <Map s="Sim|Organism|Stomach|Interstitial|..|Vf (lipid)" id="1259" />
+          <Map s="Sim|Organism|Stomach|Interstitial|..|Vf (protein)" id="1260" />
+          <Map s="Sim|Organism|Stomach|Interstitial|..|Vf (water)" id="1261" />
+          <Map s="Sim|Neighborhoods|Stomach_pls_Stomach_int|Aciclovir|Partition coefficient (interstitial/plasma)" id="1262" />
+          <Map s="Sim|Organism|Stomach|Intracellular|Aciclovir|Concentration" id="1263" />
+          <Map s="Sim|Organism|Stomach|Interstitial|Aciclovir|Concentration" id="1264" />
+          <Map s="Sim|Neighborhoods|Stomach_int_Stomach_cell|Aciclovir|P*SA interstitial -&gt; intracellular" id="1265" />
+          <Map s="Sim|Neighborhoods|Stomach_int_Stomach_cell|Aciclovir|P*SA intracellular -&gt; interstitial" id="1266" />
+          <Map s="Sim|Organism|Stomach|Interstitial|..|Volume" id="1267" />
+          <Map s="V_sto" id="1268" />
+          <Map s="Sim|Organism|Stomach|Plasma|..|Blood flow rate" id="1269" />
+          <Map s="Sim|Organism|Stomach|Plasma|Aciclovir|Concentration" id="1270" />
+          <Map s="Sim|Neighborhoods|Stomach_pls_Stomach_bc|Surface area (blood cells/plasma)" id="1271" />
+          <Map s="Sim|Organism|Stomach|Plasma|..|Fraction vascular" id="1272" />
+          <Map s="Sim|Organism|Stomach|Plasma|..|Volume" id="1273" />
+          <Map s="Sim|Neighborhoods|Stomach_pls_Stomach_int|Aciclovir|P (plasma&lt;-&gt;interstitial)" id="1274" />
+          <Map s="Sim|Organism|Lumen|UpperIleum|Effective surface area" id="1275" />
+          <Map s="Sim|Organism|SmallIntestine|Mucosa|UpperIleum|Plasma|Aciclovir|Concentration" id="1276" />
+          <Map s="Sim|Organism|Lumen|UpperIleum|Aciclovir|Effective concentration in lumen" id="1277" />
+          <Map s="Sim|Organism|Lumen|UpperIleum|..|Paracellular absorption sink condition" id="1278" />
+          <Map s="Sim|Neighborhoods|Lumen_uil_UpperIleum_pls|Aciclovir|DrugAbsorption_para|ProcessRate" id="1279" />
+          <Map s="Sim|Neighborhoods|Lumen_uil_UpperIleum_pls|Aciclovir|Drug absorption rate (lumen to mucosa)" id="1280" />
+          <Map s="Sim|Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|Aciclovir|Concentration" id="1281" />
+          <Map s="Sim|Neighborhoods|Lumen_uil_UpperIleum_cell|Aciclovir|P_int_trans_cell_lum_factor" id="1282" />
+          <Map s="Sim|Neighborhoods|Lumen_uil_UpperIleum_cell|Aciclovir|P_int_trans_lum_cell_factor" id="1283" />
+          <Map s="Sim|Organism|Lumen|UpperIleum|..|Transcellular absorption sink condition" id="1284" />
+          <Map s="Sim|Neighborhoods|UpperIleum_int_UpperIleum_cell|Aciclovir|Partition coefficient (intracellular/plasma)" id="1285" />
+          <Map s="Sim|Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|pH" id="1286" />
+          <Map s="Sim|Organism|Lumen|UpperIleum|pH" id="1287" />
+          <Map s="Sim|Neighborhoods|Lumen_uil_UpperIleum_cell|Aciclovir|DrugAbsorption_trans|ProcessRate" id="1288" />
+          <Map s="Sim|Neighborhoods|Lumen_uil_UpperIleum_cell|Aciclovir|Drug absorption rate (lumen to mucosa)" id="1289" />
+          <Map s="Sim|Organism|SmallIntestine|Mucosa|UpperIleum|Plasma|..|Blood flow rate" id="1290" />
+          <Map s="Sim|Neighborhoods|UpperIleum_pls_PortalVein_pls|Aciclovir|Mass transfer rate (mucosa to portal vein plasma)" id="1291" />
+          <Map s="Sim|Organism|SmallIntestine|Mucosa|UpperIleum|BloodCells|Aciclovir|Concentration" id="1292" />
+          <Map s="Sim|Organism|SmallIntestine|Mucosa|UpperIleum|BloodCells|..|Blood flow rate" id="1293" />
+          <Map s="Sim|Neighborhoods|UpperIleum_bc_PortalVein_bc|Aciclovir|Mass transfer rate (mucosa to portal vein blood cells)" id="1294" />
+          <Map s="Sim|Organism|SmallIntestine|BloodCells|..|Blood flow rate" id="1295" />
+          <Map s="Sim|Organism|SmallIntestine|BloodCells|..|Mucosa blood flow fraction" id="1296" />
+          <Map s="Sim|Organism|SmallIntestine|BloodCells|Aciclovir|Concentration" id="1297" />
+          <Map s="C" id="1298" />
+          <Map s="Sim|Organism|SmallIntestine|Interstitial|..|Vf (lipid)" id="1299" />
+          <Map s="Sim|Organism|SmallIntestine|Interstitial|..|Vf (protein)" id="1300" />
+          <Map s="Sim|Organism|SmallIntestine|Interstitial|..|Vf (water)" id="1301" />
+          <Map s="Sim|Neighborhoods|SmallIntestine_pls_SmallIntestine_int|Aciclovir|Partition coefficient (interstitial/plasma)" id="1302" />
+          <Map s="Sim|Organism|SmallIntestine|Intracellular|Aciclovir|Concentration" id="1303" />
+          <Map s="Sim|Organism|SmallIntestine|Interstitial|Aciclovir|Concentration" id="1304" />
+          <Map s="Sim|Neighborhoods|SmallIntestine_int_SmallIntestine_cell|Aciclovir|P*SA interstitial -&gt; intracellular" id="1305" />
+          <Map s="Sim|Neighborhoods|SmallIntestine_int_SmallIntestine_cell|Aciclovir|P*SA intracellular -&gt; interstitial" id="1306" />
+          <Map s="Sim|Organism|SmallIntestine|Interstitial|..|Volume" id="1307" />
+          <Map s="V_sin" id="1308" />
+          <Map s="Sim|Organism|SmallIntestine|Volume (mucosa)" id="1309" />
+          <Map s="Sim|Organism|SmallIntestine|Plasma|..|Blood flow rate" id="1310" />
+          <Map s="Sim|Organism|SmallIntestine|Plasma|..|Mucosa blood flow fraction" id="1311" />
+          <Map s="Sim|Organism|SmallIntestine|Plasma|Aciclovir|Concentration" id="1312" />
+          <Map s="Sim|Neighborhoods|SmallIntestine_pls_SmallIntestine_bc|Surface area (blood cells/plasma)" id="1313" />
+          <Map s="Sim|Organism|SmallIntestine|Plasma|..|Fraction vascular" id="1314" />
+          <Map s="Sim|Organism|SmallIntestine|Plasma|..|Volume" id="1315" />
+          <Map s="Sim|Organism|SmallIntestine|Plasma|..|Volume (mucosa)" id="1316" />
+          <Map s="Sim|Neighborhoods|SmallIntestine_pls_SmallIntestine_int|Aciclovir|P (plasma&lt;-&gt;interstitial)" id="1317" />
+          <Map s="Sim|Organism|SmallIntestine|Mucosa|Duodenum|Plasma|..|Blood flow rate" id="1318" />
+          <Map s="Sim|Neighborhoods|SmallIntestine_pls_Duodenum_pls|Aciclovir|Mass transfer rate (intestine to mucosa plasma)" id="1319" />
+          <Map s="MassTransferIntestineToMucosaPlasmaRate" id="1320" />
+          <Map s="Sim|Organism|SmallIntestine|Mucosa|Duodenum|BloodCells|..|Blood flow rate" id="1321" />
+          <Map s="Sim|Neighborhoods|SmallIntestine_bc_Duodenum_bc|Aciclovir|Mass transfer rate (intestine to mucosa blood cells)" id="1322" />
+          <Map s="MassTransferIntestineToMucosaBCRate" id="1323" />
+          <Map s="Sim|Neighborhoods|SmallIntestine_pls_UpperJejunum_pls|Aciclovir|Mass transfer rate (intestine to mucosa plasma)" id="1324" />
+          <Map s="Sim|Neighborhoods|SmallIntestine_bc_UpperJejunum_bc|Aciclovir|Mass transfer rate (intestine to mucosa blood cells)" id="1325" />
+          <Map s="Sim|Neighborhoods|SmallIntestine_pls_LowerJejunum_pls|Aciclovir|Mass transfer rate (intestine to mucosa plasma)" id="1326" />
+          <Map s="Sim|Neighborhoods|SmallIntestine_bc_LowerJejunum_bc|Aciclovir|Mass transfer rate (intestine to mucosa blood cells)" id="1327" />
+          <Map s="Sim|Neighborhoods|SmallIntestine_pls_UpperIleum_pls|Aciclovir|Mass transfer rate (intestine to mucosa plasma)" id="1328" />
+          <Map s="Sim|Neighborhoods|SmallIntestine_bc_UpperIleum_bc|Aciclovir|Mass transfer rate (intestine to mucosa blood cells)" id="1329" />
+          <Map s="Sim|Organism|Lumen|LowerIleum|Effective surface area" id="1330" />
+          <Map s="Sim|Organism|SmallIntestine|Mucosa|LowerIleum|Plasma|Aciclovir|Concentration" id="1331" />
+          <Map s="Sim|Organism|Lumen|LowerIleum|Aciclovir|Effective concentration in lumen" id="1332" />
+          <Map s="Sim|Organism|Lumen|LowerIleum|..|Paracellular absorption sink condition" id="1333" />
+          <Map s="Sim|Neighborhoods|Lumen_lil_LowerIleum_pls|Aciclovir|DrugAbsorption_para|ProcessRate" id="1334" />
+          <Map s="Sim|Neighborhoods|Lumen_lil_LowerIleum_pls|Aciclovir|Drug absorption rate (lumen to mucosa)" id="1335" />
+          <Map s="Sim|Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|Aciclovir|Concentration" id="1336" />
+          <Map s="Sim|Neighborhoods|Lumen_lil_LowerIleum_cell|Aciclovir|P_int_trans_cell_lum_factor" id="1337" />
+          <Map s="Sim|Neighborhoods|Lumen_lil_LowerIleum_cell|Aciclovir|P_int_trans_lum_cell_factor" id="1338" />
+          <Map s="Sim|Organism|Lumen|LowerIleum|..|Transcellular absorption sink condition" id="1339" />
+          <Map s="Sim|Neighborhoods|LowerIleum_int_LowerIleum_cell|Aciclovir|Partition coefficient (intracellular/plasma)" id="1340" />
+          <Map s="Sim|Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|pH" id="1341" />
+          <Map s="Sim|Organism|Lumen|LowerIleum|pH" id="1342" />
+          <Map s="Sim|Neighborhoods|Lumen_lil_LowerIleum_cell|Aciclovir|DrugAbsorption_trans|ProcessRate" id="1343" />
+          <Map s="Sim|Neighborhoods|Lumen_lil_LowerIleum_cell|Aciclovir|Drug absorption rate (lumen to mucosa)" id="1344" />
+          <Map s="Sim|Organism|SmallIntestine|Mucosa|LowerIleum|Plasma|..|Blood flow rate" id="1345" />
+          <Map s="Sim|Neighborhoods|SmallIntestine_pls_LowerIleum_pls|Aciclovir|Mass transfer rate (intestine to mucosa plasma)" id="1346" />
+          <Map s="Sim|Organism|SmallIntestine|Mucosa|LowerIleum|BloodCells|..|Blood flow rate" id="1347" />
+          <Map s="Sim|Neighborhoods|SmallIntestine_bc_LowerIleum_bc|Aciclovir|Mass transfer rate (intestine to mucosa blood cells)" id="1348" />
+          <Map s="Sim|Neighborhoods|LowerIleum_pls_PortalVein_pls|Aciclovir|Mass transfer rate (mucosa to portal vein plasma)" id="1349" />
+          <Map s="Sim|Organism|SmallIntestine|Mucosa|LowerIleum|BloodCells|Aciclovir|Concentration" id="1350" />
+          <Map s="Sim|Neighborhoods|LowerIleum_bc_PortalVein_bc|Aciclovir|Mass transfer rate (mucosa to portal vein blood cells)" id="1351" />
+          <Map s="Sim|Organism|LargeIntestine|BloodCells|..|Blood flow rate" id="1352" />
+          <Map s="Sim|Organism|LargeIntestine|BloodCells|..|Mucosa blood flow fraction" id="1353" />
+          <Map s="Sim|Organism|LargeIntestine|BloodCells|Aciclovir|Concentration" id="1354" />
+          <Map s="Sim|Organism|LargeIntestine|Interstitial|..|Vf (lipid)" id="1355" />
+          <Map s="Sim|Organism|LargeIntestine|Interstitial|..|Vf (protein)" id="1356" />
+          <Map s="Sim|Organism|LargeIntestine|Interstitial|..|Vf (water)" id="1357" />
+          <Map s="Sim|Neighborhoods|LargeIntestine_pls_LargeIntestine_int|Aciclovir|Partition coefficient (interstitial/plasma)" id="1358" />
+          <Map s="Sim|Organism|LargeIntestine|Intracellular|Aciclovir|Concentration" id="1359" />
+          <Map s="Sim|Organism|LargeIntestine|Interstitial|Aciclovir|Concentration" id="1360" />
+          <Map s="Sim|Neighborhoods|LargeIntestine_int_LargeIntestine_cell|Aciclovir|P*SA interstitial -&gt; intracellular" id="1361" />
+          <Map s="Sim|Neighborhoods|LargeIntestine_int_LargeIntestine_cell|Aciclovir|P*SA intracellular -&gt; interstitial" id="1362" />
+          <Map s="Sim|Organism|LargeIntestine|Interstitial|..|Volume" id="1363" />
+          <Map s="V_lin" id="1364" />
+          <Map s="Sim|Organism|LargeIntestine|Volume (mucosa)" id="1365" />
+          <Map s="Sim|Organism|LargeIntestine|Plasma|Aciclovir|Concentration" id="1366" />
+          <Map s="Sim|Neighborhoods|LargeIntestine_pls_LargeIntestine_bc|Surface area (blood cells/plasma)" id="1367" />
+          <Map s="Sim|Organism|LargeIntestine|Plasma|..|Fraction vascular" id="1368" />
+          <Map s="Sim|Organism|LargeIntestine|Plasma|..|Volume" id="1369" />
+          <Map s="Sim|Organism|LargeIntestine|Plasma|..|Volume (mucosa)" id="1370" />
+          <Map s="Sim|Neighborhoods|LargeIntestine_pls_LargeIntestine_int|Aciclovir|P (plasma&lt;-&gt;interstitial)" id="1371" />
+          <Map s="Sim|Organism|LargeIntestine|Plasma|..|Blood flow rate" id="1372" />
+          <Map s="Sim|Organism|LargeIntestine|Plasma|..|Mucosa blood flow fraction" id="1373" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|Caecum|Plasma|..|Blood flow rate" id="1374" />
+          <Map s="Sim|Neighborhoods|LargeIntestine_pls_Caecum_pls|Aciclovir|Mass transfer rate (intestine to mucosa plasma)" id="1375" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|Caecum|BloodCells|..|Blood flow rate" id="1376" />
+          <Map s="Sim|Neighborhoods|LargeIntestine_bc_Caecum_bc|Aciclovir|Mass transfer rate (intestine to mucosa blood cells)" id="1377" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|ColonAscendens|Plasma|..|Blood flow rate" id="1378" />
+          <Map s="Sim|Neighborhoods|LargeIntestine_pls_ColonAscendens_pls|Aciclovir|Mass transfer rate (intestine to mucosa plasma)" id="1379" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|ColonAscendens|BloodCells|..|Blood flow rate" id="1380" />
+          <Map s="Sim|Neighborhoods|LargeIntestine_bc_ColonAscendens_bc|Aciclovir|Mass transfer rate (intestine to mucosa blood cells)" id="1381" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|ColonTransversum|Plasma|..|Blood flow rate" id="1382" />
+          <Map s="Sim|Neighborhoods|LargeIntestine_pls_ColonTransversum_pls|Aciclovir|Mass transfer rate (intestine to mucosa plasma)" id="1383" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|ColonTransversum|BloodCells|..|Blood flow rate" id="1384" />
+          <Map s="Sim|Neighborhoods|LargeIntestine_bc_ColonTransversum_bc|Aciclovir|Mass transfer rate (intestine to mucosa blood cells)" id="1385" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|ColonDescendens|Plasma|..|Blood flow rate" id="1386" />
+          <Map s="Sim|Neighborhoods|LargeIntestine_pls_ColonDescendens_pls|Aciclovir|Mass transfer rate (intestine to mucosa plasma)" id="1387" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|ColonDescendens|BloodCells|..|Blood flow rate" id="1388" />
+          <Map s="Sim|Neighborhoods|LargeIntestine_bc_ColonDescendens_bc|Aciclovir|Mass transfer rate (intestine to mucosa blood cells)" id="1389" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|ColonSigmoid|Plasma|..|Blood flow rate" id="1390" />
+          <Map s="Sim|Neighborhoods|LargeIntestine_pls_ColonSigmoid_pls|Aciclovir|Mass transfer rate (intestine to mucosa plasma)" id="1391" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|ColonSigmoid|BloodCells|..|Blood flow rate" id="1392" />
+          <Map s="Sim|Neighborhoods|LargeIntestine_bc_ColonSigmoid_bc|Aciclovir|Mass transfer rate (intestine to mucosa blood cells)" id="1393" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|Rectum|Plasma|..|Blood flow rate" id="1394" />
+          <Map s="Sim|Neighborhoods|LargeIntestine_pls_Rectum_pls|Aciclovir|Mass transfer rate (intestine to mucosa plasma)" id="1395" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|Rectum|BloodCells|..|Blood flow rate" id="1396" />
+          <Map s="Sim|Neighborhoods|LargeIntestine_bc_Rectum_bc|Aciclovir|Mass transfer rate (intestine to mucosa blood cells)" id="1397" />
+          <Map s="Sim|Organism|Liver|Interstitial|..|Volume" id="1398" />
+          <Map s="Sim|Organism|Liver|Plasma|..|Fraction vascular" id="1399" />
+          <Map s="Sim|Organism|Liver|Plasma|..|Volume" id="1400" />
+          <Map s="Sim|Organism|Gallbladder|Aciclovir" id="1401" />
+          <Map s="Sim|Organism|Gallbladder|Gallbladder ejection fraction" id="1402" />
+          <Map s="EHC_EjectionFraction" id="1403" />
+          <Map s="Sim|Organism|Gallbladder|Gallbladder ejection half-time" id="1404" />
+          <Map s="EHC_Halftime" id="1405" />
+          <Map s="Sim|Organism|Gallbladder|Gallbladder emptying active" id="1406" />
+          <Map s="EHC_Active" id="1407" />
+          <Map s="Sim|Organism|Liver|Periportal|Interstitial|..|Vf (lipid)" id="1408" />
+          <Map s="Sim|Organism|Liver|Periportal|Interstitial|..|Vf (protein)" id="1409" />
+          <Map s="Sim|Organism|Liver|Periportal|Interstitial|..|Vf (water)" id="1410" />
+          <Map s="Sim|Neighborhoods|Periportal_pls_Periportal_int|Aciclovir|Partition coefficient (interstitial/plasma)" id="1411" />
+          <Map s="Sim|Neighborhoods|Periportal_int_Periportal_cell|Aciclovir|P*SA interstitial -&gt; intracellular" id="1412" />
+          <Map s="Sim|Neighborhoods|Periportal_int_Periportal_cell|Aciclovir|P*SA intracellular -&gt; interstitial" id="1413" />
+          <Map s="Sim|Neighborhoods|Liver_int_Liver_cell|Surface area (interstitial/intracellular)" id="1414" />
+          <Map s="SA_int_cell" id="1415" />
+          <Map s="Sim|Neighborhoods|Periportal_pls_Periportal_bc|Surface area (blood cells/plasma)" id="1416" />
+          <Map s="Sim|Neighborhoods|Liver_pls_Liver_bc|Surface area (blood cells/plasma)" id="1417" />
+          <Map s="SA_pls_bc" id="1418" />
+          <Map s="Sim|Neighborhoods|Periportal_pls_Periportal_int|Aciclovir|P (plasma&lt;-&gt;interstitial)" id="1419" />
+          <Map s="Sim|Organism|Liver|Pericentral|Interstitial|..|Vf (lipid)" id="1420" />
+          <Map s="Sim|Organism|Liver|Pericentral|Interstitial|..|Vf (protein)" id="1421" />
+          <Map s="Sim|Organism|Liver|Pericentral|Interstitial|..|Vf (water)" id="1422" />
+          <Map s="Sim|Neighborhoods|Pericentral_pls_Pericentral_int|Aciclovir|Partition coefficient (interstitial/plasma)" id="1423" />
+          <Map s="Sim|Neighborhoods|Pericentral_int_Pericentral_cell|Aciclovir|P*SA interstitial -&gt; intracellular" id="1424" />
+          <Map s="Sim|Neighborhoods|Pericentral_int_Pericentral_cell|Aciclovir|P*SA intracellular -&gt; interstitial" id="1425" />
+          <Map s="Sim|Neighborhoods|Pericentral_int_Pericentral_cell|Aciclovir|Partition coefficient (interstitial/water)" id="1426" />
+          <Map s="Sim|Neighborhoods|Pericentral_int_Pericentral_cell|Aciclovir|Partition coefficient (intracellular/water)" id="1427" />
+          <Map s="Sim|Neighborhoods|Pericentral_pls_Pericentral_bc|Surface area (blood cells/plasma)" id="1428" />
+          <Map s="Sim|Neighborhoods|Pericentral_pls_Pericentral_int|Aciclovir|P (plasma&lt;-&gt;interstitial)" id="1429" />
+          <Map s="Sim|Organism|Lung|BloodCells|Aciclovir|Concentration" id="1430" />
+          <Map s="Sim|Organism|Lung|Interstitial|..|Vf (lipid)" id="1431" />
+          <Map s="Sim|Organism|Lung|Interstitial|..|Vf (protein)" id="1432" />
+          <Map s="Sim|Organism|Lung|Interstitial|..|Vf (water)" id="1433" />
+          <Map s="Sim|Neighborhoods|Lung_pls_Lung_int|Aciclovir|Partition coefficient (interstitial/plasma)" id="1434" />
+          <Map s="Sim|Organism|Lung|Intracellular|Aciclovir|Concentration" id="1435" />
+          <Map s="Sim|Organism|Lung|Interstitial|Aciclovir|Concentration" id="1436" />
+          <Map s="Sim|Neighborhoods|Lung_int_Lung_cell|Aciclovir|P*SA interstitial -&gt; intracellular" id="1437" />
+          <Map s="Sim|Neighborhoods|Lung_int_Lung_cell|Aciclovir|P*SA intracellular -&gt; interstitial" id="1438" />
+          <Map s="Sim|Organism|Lung|Interstitial|..|Volume" id="1439" />
+          <Map s="V_lng" id="1440" />
+          <Map s="Sim|Organism|Lung|Plasma|Aciclovir|Concentration" id="1441" />
+          <Map s="Sim|Neighborhoods|Lung_pls_Lung_bc|Surface area (blood cells/plasma)" id="1442" />
+          <Map s="Sim|Organism|Lung|Plasma|..|Fraction vascular" id="1443" />
+          <Map s="Sim|Organism|Lung|Plasma|..|Volume" id="1444" />
+          <Map s="Sim|Neighborhoods|Lung_pls_Lung_int|Aciclovir|P (plasma&lt;-&gt;interstitial)" id="1445" />
+          <Map s="Sim|Organism|Muscle|BloodCells|..|Blood flow rate" id="1446" />
+          <Map s="Sim|Organism|Muscle|Interstitial|..|Vf (lipid)" id="1447" />
+          <Map s="Sim|Organism|Muscle|Interstitial|..|Vf (protein)" id="1448" />
+          <Map s="Sim|Organism|Muscle|Interstitial|..|Vf (water)" id="1449" />
+          <Map s="Sim|Neighborhoods|Muscle_pls_Muscle_int|Aciclovir|Partition coefficient (interstitial/plasma)" id="1450" />
+          <Map s="Sim|Organism|Muscle|Intracellular|Aciclovir|Concentration" id="1451" />
+          <Map s="Sim|Organism|Muscle|Interstitial|Aciclovir|Concentration" id="1452" />
+          <Map s="Sim|Neighborhoods|Muscle_int_Muscle_cell|Aciclovir|P*SA interstitial -&gt; intracellular" id="1453" />
+          <Map s="Sim|Neighborhoods|Muscle_int_Muscle_cell|Aciclovir|P*SA intracellular -&gt; interstitial" id="1454" />
+          <Map s="Sim|Organism|Muscle|Interstitial|..|Volume" id="1455" />
+          <Map s="V_mus" id="1456" />
+          <Map s="Sim|Neighborhoods|Muscle_pls_Muscle_bc|Surface area (blood cells/plasma)" id="1457" />
+          <Map s="Sim|Organism|Muscle|Plasma|..|Fraction vascular" id="1458" />
+          <Map s="Sim|Organism|Muscle|Plasma|..|Volume" id="1459" />
+          <Map s="Sim|Neighborhoods|Muscle_pls_Muscle_int|Aciclovir|P (plasma&lt;-&gt;interstitial)" id="1460" />
+          <Map s="Sim|Organism|Muscle|Plasma|..|Blood flow rate" id="1461" />
+          <Map s="Sim|Organism|Pancreas|BloodCells|..|Blood flow rate" id="1462" />
+          <Map s="Sim|Organism|Pancreas|BloodCells|Aciclovir|Concentration" id="1463" />
+          <Map s="Sim|Organism|Pancreas|Interstitial|..|Vf (lipid)" id="1464" />
+          <Map s="Sim|Organism|Pancreas|Interstitial|..|Vf (protein)" id="1465" />
+          <Map s="Sim|Organism|Pancreas|Interstitial|..|Vf (water)" id="1466" />
+          <Map s="Sim|Neighborhoods|Pancreas_pls_Pancreas_int|Aciclovir|Partition coefficient (interstitial/plasma)" id="1467" />
+          <Map s="Sim|Organism|Pancreas|Intracellular|Aciclovir|Concentration" id="1468" />
+          <Map s="Sim|Organism|Pancreas|Interstitial|Aciclovir|Concentration" id="1469" />
+          <Map s="Sim|Neighborhoods|Pancreas_int_Pancreas_cell|Aciclovir|P*SA interstitial -&gt; intracellular" id="1470" />
+          <Map s="Sim|Neighborhoods|Pancreas_int_Pancreas_cell|Aciclovir|P*SA intracellular -&gt; interstitial" id="1471" />
+          <Map s="Sim|Organism|Pancreas|Interstitial|..|Volume" id="1472" />
+          <Map s="V_pan" id="1473" />
+          <Map s="Sim|Organism|Pancreas|Plasma|Aciclovir|Concentration" id="1474" />
+          <Map s="Sim|Neighborhoods|Pancreas_pls_Pancreas_bc|Surface area (blood cells/plasma)" id="1475" />
+          <Map s="Sim|Organism|Pancreas|Plasma|..|Fraction vascular" id="1476" />
+          <Map s="Sim|Organism|Pancreas|Plasma|..|Volume" id="1477" />
+          <Map s="Sim|Neighborhoods|Pancreas_pls_Pancreas_int|Aciclovir|P (plasma&lt;-&gt;interstitial)" id="1478" />
+          <Map s="Sim|Organism|Pancreas|Plasma|..|Blood flow rate" id="1479" />
+          <Map s="Sim|Organism|Lumen|Rectum|Effective surface area" id="1480" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|Rectum|Plasma|Aciclovir|Concentration" id="1481" />
+          <Map s="Sim|Organism|Lumen|Rectum|Aciclovir|Effective concentration in lumen" id="1482" />
+          <Map s="Sim|Organism|Lumen|Rectum|..|Paracellular absorption sink condition" id="1483" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|Rectum|Intracellular|Aciclovir|Concentration" id="1484" />
+          <Map s="Sim|Neighborhoods|Lumen_rect_Rectum_cell|Aciclovir|P_int_trans_cell_lum_factor" id="1485" />
+          <Map s="Sim|Neighborhoods|Lumen_rect_Rectum_cell|Aciclovir|P_int_trans_lum_cell_factor" id="1486" />
+          <Map s="Sim|Organism|Lumen|Rectum|..|Transcellular absorption sink condition" id="1487" />
+          <Map s="Sim|Neighborhoods|Rectum_int_Rectum_cell|Aciclovir|Partition coefficient (intracellular/plasma)" id="1488" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|Rectum|Intracellular|pH" id="1489" />
+          <Map s="Sim|Organism|Lumen|Rectum|pH" id="1490" />
+          <Map s="Sim|Neighborhoods|Lumen_rect_Rectum_cell|Aciclovir|DrugAbsorption_trans|ProcessRate" id="1491" />
+          <Map s="Sim|Neighborhoods|Lumen_rect_Rectum_cell|Aciclovir|Drug absorption rate (lumen to mucosa)" id="1492" />
+          <Map s="Sim|Neighborhoods|Rectum_pls_PortalVein_pls|Aciclovir|Mass transfer rate (mucosa to portal vein plasma)" id="1493" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|Rectum|BloodCells|Aciclovir|Concentration" id="1494" />
+          <Map s="Sim|Neighborhoods|Rectum_bc_PortalVein_bc|Aciclovir|Mass transfer rate (mucosa to portal vein blood cells)" id="1495" />
+          <Map s="Sim|Organism|PortalVein|BloodCells|Aciclovir|Concentration" id="1496" />
+          <Map s="Sim|Organism|PortalVein|Plasma|Aciclovir|Concentration" id="1497" />
+          <Map s="Sim|Neighborhoods|PortalVein_pls_PortalVein_bc|Surface area (blood cells/plasma)" id="1498" />
+          <Map s="Sim|Organism|PortalVein|Plasma|..|Volume" id="1499" />
+          <Map s="Sim|Organism|Skin|BloodCells|..|Blood flow rate" id="1500" />
+          <Map s="Sim|Organism|Skin|Interstitial|..|Vf (lipid)" id="1501" />
+          <Map s="Sim|Organism|Skin|Interstitial|..|Vf (protein)" id="1502" />
+          <Map s="Sim|Organism|Skin|Interstitial|..|Vf (water)" id="1503" />
+          <Map s="Sim|Neighborhoods|Skin_pls_Skin_int|Aciclovir|Partition coefficient (interstitial/plasma)" id="1504" />
+          <Map s="Sim|Organism|Skin|Intracellular|Aciclovir|Concentration" id="1505" />
+          <Map s="Sim|Organism|Skin|Interstitial|Aciclovir|Concentration" id="1506" />
+          <Map s="Sim|Neighborhoods|Skin_int_Skin_cell|Aciclovir|P*SA interstitial -&gt; intracellular" id="1507" />
+          <Map s="Sim|Neighborhoods|Skin_int_Skin_cell|Aciclovir|P*SA intracellular -&gt; interstitial" id="1508" />
+          <Map s="Sim|Organism|Skin|Interstitial|..|Volume" id="1509" />
+          <Map s="V_skn" id="1510" />
+          <Map s="Sim|Neighborhoods|Skin_pls_Skin_bc|Surface area (blood cells/plasma)" id="1511" />
+          <Map s="Sim|Organism|Skin|Plasma|..|Fraction vascular" id="1512" />
+          <Map s="Sim|Organism|Skin|Plasma|..|Volume" id="1513" />
+          <Map s="Sim|Neighborhoods|Skin_pls_Skin_int|Aciclovir|P (plasma&lt;-&gt;interstitial)" id="1514" />
+          <Map s="Sim|Organism|Skin|Plasma|..|Blood flow rate" id="1515" />
+          <Map s="Sim|Organism|Spleen|BloodCells|..|Blood flow rate" id="1516" />
+          <Map s="Sim|Organism|Spleen|BloodCells|Aciclovir|Concentration" id="1517" />
+          <Map s="Sim|Organism|Spleen|Interstitial|..|Vf (lipid)" id="1518" />
+          <Map s="Sim|Organism|Spleen|Interstitial|..|Vf (protein)" id="1519" />
+          <Map s="Sim|Organism|Spleen|Interstitial|..|Vf (water)" id="1520" />
+          <Map s="Sim|Neighborhoods|Spleen_pls_Spleen_int|Aciclovir|Partition coefficient (interstitial/plasma)" id="1521" />
+          <Map s="Sim|Organism|Spleen|Intracellular|Aciclovir|Concentration" id="1522" />
+          <Map s="Sim|Organism|Spleen|Interstitial|Aciclovir|Concentration" id="1523" />
+          <Map s="Sim|Neighborhoods|Spleen_int_Spleen_cell|Aciclovir|P*SA interstitial -&gt; intracellular" id="1524" />
+          <Map s="Sim|Neighborhoods|Spleen_int_Spleen_cell|Aciclovir|P*SA intracellular -&gt; interstitial" id="1525" />
+          <Map s="Sim|Organism|Spleen|Interstitial|..|Volume" id="1526" />
+          <Map s="V_spl" id="1527" />
+          <Map s="Sim|Organism|Spleen|Plasma|..|Blood flow rate" id="1528" />
+          <Map s="Sim|Organism|Spleen|Plasma|Aciclovir|Concentration" id="1529" />
+          <Map s="Sim|Neighborhoods|Spleen_pls_Spleen_bc|Surface area (blood cells/plasma)" id="1530" />
+          <Map s="Sim|Organism|Spleen|Plasma|..|Fraction vascular" id="1531" />
+          <Map s="Sim|Organism|Spleen|Plasma|..|Volume" id="1532" />
+          <Map s="Sim|Neighborhoods|Spleen_pls_Spleen_int|Aciclovir|P (plasma&lt;-&gt;interstitial)" id="1533" />
+          <Map s="..|SalivaPlasmaRatio" id="1534" />
+          <Map s="R" id="1535" />
+          <Map s="Sim|Organism|Saliva|Saliva|pH (saliva)" id="1536" />
+          <Map s="pH_slv" id="1537" />
+          <Map s="Sim|Organism|pH (plasma)" id="1538" />
+          <Map s="pH_PLS" id="1539" />
+          <Map s="Sim|Organism|Saliva|SalivaGland|..|Saliva flow rate" id="1540" />
+          <Map s="Q_slv" id="1541" />
+          <Map s="Sim|Organism|Saliva|SalivaGland|..|..|ArterialBlood|Plasma|Aciclovir|Concentration" id="1542" />
+          <Map s="Sim|Organism|Saliva|Saliva|Aciclovir|Concentration" id="1543" />
+          <Map s="C_slv" id="1544" />
+          <Map s="Sim|Neighborhoods|Saliva_slv_Saliva_slv|Aciclovir|Partition coefficient (intracellular/plasma)" id="1545" />
+          <Map s="K_slv_pls" id="1546" />
+          <Map s="Sim|Aciclovir|Mucosa permeability scale factor (transcellular)" id="1547" />
+          <Map s="P_int_scalefactor" id="1548" />
+          <Map s="Sim|Organism|SmallIntestine|Mucosa|Duodenum|Interstitial|..|Vf (lipid)" id="1549" />
+          <Map s="Sim|Organism|SmallIntestine|Mucosa|Duodenum|Interstitial|..|Vf (protein)" id="1550" />
+          <Map s="Sim|Organism|SmallIntestine|Mucosa|Duodenum|Interstitial|..|Vf (water)" id="1551" />
+          <Map s="Sim|Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|Aciclovir|Concentration" id="1552" />
+          <Map s="Sim|Organism|SmallIntestine|Mucosa|Duodenum|Interstitial|Aciclovir|Concentration" id="1553" />
+          <Map s="Sim|Neighborhoods|Duodenum_int_Duodenum_cell|Aciclovir|P*SA interstitial -&gt; intracellular" id="1554" />
+          <Map s="Sim|Neighborhoods|Duodenum_int_Duodenum_cell|Aciclovir|P*SA intracellular -&gt; interstitial" id="1555" />
+          <Map s="Sim|Organism|Lumen|Duodenum|Effective surface area" id="1556" />
+          <Map s="Sim|Organism|Lumen|Duodenum|Microvilli factor" id="1557" />
+          <Map s="MicrovilliFactor" id="1558" />
+          <Map s="Sim|Organism|SmallIntestine|Mucosa|Duodenum|BloodCells|Aciclovir|Concentration" id="1559" />
+          <Map s="Sim|Organism|SmallIntestine|Mucosa|Duodenum|Plasma|Aciclovir|Concentration" id="1560" />
+          <Map s="Sim|Neighborhoods|Duodenum_pls_Duodenum_bc|Surface area (blood cells/plasma)" id="1561" />
+          <Map s="Sim|Organism|SmallIntestine|Mucosa|Duodenum|Plasma|..|Fraction vascular" id="1562" />
+          <Map s="Sim|Organism|SmallIntestine|Mucosa|Duodenum|Plasma|..|Volume" id="1563" />
+          <Map s="Sim|Neighborhoods|Duodenum_pls_Duodenum_int|Aciclovir|P (plasma&lt;-&gt;interstitial)" id="1564" />
+          <Map s="Sim|Neighborhoods|Duodenum_pls_Duodenum_int|Aciclovir|Partition coefficient (interstitial/plasma)" id="1565" />
+          <Map s="Sim|Organism|SmallIntestine|Mucosa|UpperJejunum|Interstitial|..|Vf (lipid)" id="1566" />
+          <Map s="Sim|Organism|SmallIntestine|Mucosa|UpperJejunum|Interstitial|..|Vf (protein)" id="1567" />
+          <Map s="Sim|Organism|SmallIntestine|Mucosa|UpperJejunum|Interstitial|..|Vf (water)" id="1568" />
+          <Map s="Sim|Organism|SmallIntestine|Mucosa|UpperJejunum|Interstitial|Aciclovir|Concentration" id="1569" />
+          <Map s="Sim|Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Aciclovir|P*SA interstitial -&gt; intracellular" id="1570" />
+          <Map s="Sim|Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Aciclovir|P*SA intracellular -&gt; interstitial" id="1571" />
+          <Map s="Sim|Organism|Lumen|UpperJejunum|Microvilli factor" id="1572" />
+          <Map s="Sim|Neighborhoods|UpperJejunum_pls_UpperJejunum_bc|Surface area (blood cells/plasma)" id="1573" />
+          <Map s="Sim|Organism|SmallIntestine|Mucosa|UpperJejunum|Plasma|..|Fraction vascular" id="1574" />
+          <Map s="Sim|Organism|SmallIntestine|Mucosa|UpperJejunum|Plasma|..|Volume" id="1575" />
+          <Map s="Sim|Neighborhoods|UpperJejunum_pls_UpperJejunum_int|Aciclovir|P (plasma&lt;-&gt;interstitial)" id="1576" />
+          <Map s="Sim|Neighborhoods|UpperJejunum_pls_UpperJejunum_int|Aciclovir|Partition coefficient (interstitial/plasma)" id="1577" />
+          <Map s="Sim|Organism|SmallIntestine|Mucosa|LowerJejunum|Interstitial|..|Vf (lipid)" id="1578" />
+          <Map s="Sim|Organism|SmallIntestine|Mucosa|LowerJejunum|Interstitial|..|Vf (protein)" id="1579" />
+          <Map s="Sim|Organism|SmallIntestine|Mucosa|LowerJejunum|Interstitial|..|Vf (water)" id="1580" />
+          <Map s="Sim|Organism|SmallIntestine|Mucosa|LowerJejunum|Interstitial|Aciclovir|Concentration" id="1581" />
+          <Map s="Sim|Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Aciclovir|P*SA interstitial -&gt; intracellular" id="1582" />
+          <Map s="Sim|Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Aciclovir|P*SA intracellular -&gt; interstitial" id="1583" />
+          <Map s="Sim|Organism|Lumen|LowerJejunum|Microvilli factor" id="1584" />
+          <Map s="Sim|Neighborhoods|LowerJejunum_pls_LowerJejunum_bc|Surface area (blood cells/plasma)" id="1585" />
+          <Map s="Sim|Organism|SmallIntestine|Mucosa|LowerJejunum|Plasma|..|Fraction vascular" id="1586" />
+          <Map s="Sim|Organism|SmallIntestine|Mucosa|LowerJejunum|Plasma|..|Volume" id="1587" />
+          <Map s="Sim|Neighborhoods|LowerJejunum_pls_LowerJejunum_int|Aciclovir|P (plasma&lt;-&gt;interstitial)" id="1588" />
+          <Map s="Sim|Neighborhoods|LowerJejunum_pls_LowerJejunum_int|Aciclovir|Partition coefficient (interstitial/plasma)" id="1589" />
+          <Map s="Sim|Organism|SmallIntestine|Mucosa|UpperIleum|Interstitial|..|Vf (lipid)" id="1590" />
+          <Map s="Sim|Organism|SmallIntestine|Mucosa|UpperIleum|Interstitial|..|Vf (protein)" id="1591" />
+          <Map s="Sim|Organism|SmallIntestine|Mucosa|UpperIleum|Interstitial|..|Vf (water)" id="1592" />
+          <Map s="Sim|Organism|SmallIntestine|Mucosa|UpperIleum|Interstitial|Aciclovir|Concentration" id="1593" />
+          <Map s="Sim|Neighborhoods|UpperIleum_int_UpperIleum_cell|Aciclovir|P*SA interstitial -&gt; intracellular" id="1594" />
+          <Map s="Sim|Neighborhoods|UpperIleum_int_UpperIleum_cell|Aciclovir|P*SA intracellular -&gt; interstitial" id="1595" />
+          <Map s="Sim|Organism|Lumen|UpperIleum|Microvilli factor" id="1596" />
+          <Map s="Sim|Neighborhoods|UpperIleum_pls_UpperIleum_bc|Surface area (blood cells/plasma)" id="1597" />
+          <Map s="Sim|Organism|SmallIntestine|Mucosa|UpperIleum|Plasma|..|Fraction vascular" id="1598" />
+          <Map s="Sim|Organism|SmallIntestine|Mucosa|UpperIleum|Plasma|..|Volume" id="1599" />
+          <Map s="Sim|Neighborhoods|UpperIleum_pls_UpperIleum_int|Aciclovir|P (plasma&lt;-&gt;interstitial)" id="1600" />
+          <Map s="Sim|Neighborhoods|UpperIleum_pls_UpperIleum_int|Aciclovir|Partition coefficient (interstitial/plasma)" id="1601" />
+          <Map s="Sim|Organism|SmallIntestine|Mucosa|LowerIleum|Interstitial|..|Vf (lipid)" id="1602" />
+          <Map s="Sim|Organism|SmallIntestine|Mucosa|LowerIleum|Interstitial|..|Vf (protein)" id="1603" />
+          <Map s="Sim|Organism|SmallIntestine|Mucosa|LowerIleum|Interstitial|..|Vf (water)" id="1604" />
+          <Map s="Sim|Organism|SmallIntestine|Mucosa|LowerIleum|Interstitial|Aciclovir|Concentration" id="1605" />
+          <Map s="Sim|Neighborhoods|LowerIleum_int_LowerIleum_cell|Aciclovir|P*SA interstitial -&gt; intracellular" id="1606" />
+          <Map s="Sim|Neighborhoods|LowerIleum_int_LowerIleum_cell|Aciclovir|P*SA intracellular -&gt; interstitial" id="1607" />
+          <Map s="Sim|Organism|Lumen|LowerIleum|Microvilli factor" id="1608" />
+          <Map s="Sim|Neighborhoods|LowerIleum_pls_LowerIleum_bc|Surface area (blood cells/plasma)" id="1609" />
+          <Map s="Sim|Organism|SmallIntestine|Mucosa|LowerIleum|Plasma|..|Fraction vascular" id="1610" />
+          <Map s="Sim|Organism|SmallIntestine|Mucosa|LowerIleum|Plasma|..|Volume" id="1611" />
+          <Map s="Sim|Neighborhoods|LowerIleum_pls_LowerIleum_int|Aciclovir|P (plasma&lt;-&gt;interstitial)" id="1612" />
+          <Map s="Sim|Neighborhoods|LowerIleum_pls_LowerIleum_int|Aciclovir|Partition coefficient (interstitial/plasma)" id="1613" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|Caecum|Interstitial|..|Vf (lipid)" id="1614" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|Caecum|Interstitial|..|Vf (protein)" id="1615" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|Caecum|Interstitial|..|Vf (water)" id="1616" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|Caecum|Intracellular|Aciclovir|Concentration" id="1617" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|Caecum|Interstitial|Aciclovir|Concentration" id="1618" />
+          <Map s="Sim|Neighborhoods|Caecum_int_Caecum_cell|Aciclovir|P*SA interstitial -&gt; intracellular" id="1619" />
+          <Map s="Sim|Neighborhoods|Caecum_int_Caecum_cell|Aciclovir|P*SA intracellular -&gt; interstitial" id="1620" />
+          <Map s="Sim|Organism|Lumen|Caecum|Effective surface area" id="1621" />
+          <Map s="Sim|Organism|Lumen|Caecum|Microvilli factor" id="1622" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|Caecum|BloodCells|Aciclovir|Concentration" id="1623" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|Caecum|Plasma|Aciclovir|Concentration" id="1624" />
+          <Map s="Sim|Neighborhoods|Caecum_pls_Caecum_bc|Surface area (blood cells/plasma)" id="1625" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|Caecum|Plasma|..|Fraction vascular" id="1626" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|Caecum|Plasma|..|Volume" id="1627" />
+          <Map s="Sim|Neighborhoods|Caecum_pls_Caecum_int|Aciclovir|P (plasma&lt;-&gt;interstitial)" id="1628" />
+          <Map s="Sim|Neighborhoods|Caecum_pls_Caecum_int|Aciclovir|Partition coefficient (interstitial/plasma)" id="1629" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|ColonAscendens|Interstitial|..|Vf (lipid)" id="1630" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|ColonAscendens|Interstitial|..|Vf (protein)" id="1631" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|ColonAscendens|Interstitial|..|Vf (water)" id="1632" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|Aciclovir|Concentration" id="1633" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|ColonAscendens|Interstitial|Aciclovir|Concentration" id="1634" />
+          <Map s="Sim|Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Aciclovir|P*SA interstitial -&gt; intracellular" id="1635" />
+          <Map s="Sim|Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Aciclovir|P*SA intracellular -&gt; interstitial" id="1636" />
+          <Map s="Sim|Organism|Lumen|ColonAscendens|Effective surface area" id="1637" />
+          <Map s="Sim|Organism|Lumen|ColonAscendens|Microvilli factor" id="1638" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|ColonAscendens|BloodCells|Aciclovir|Concentration" id="1639" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|ColonAscendens|Plasma|Aciclovir|Concentration" id="1640" />
+          <Map s="Sim|Neighborhoods|ColonAscendens_pls_ColonAscendens_bc|Surface area (blood cells/plasma)" id="1641" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|ColonAscendens|Plasma|..|Fraction vascular" id="1642" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|ColonAscendens|Plasma|..|Volume" id="1643" />
+          <Map s="Sim|Neighborhoods|ColonAscendens_pls_ColonAscendens_int|Aciclovir|P (plasma&lt;-&gt;interstitial)" id="1644" />
+          <Map s="Sim|Neighborhoods|ColonAscendens_pls_ColonAscendens_int|Aciclovir|Partition coefficient (interstitial/plasma)" id="1645" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|ColonTransversum|Interstitial|..|Vf (lipid)" id="1646" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|ColonTransversum|Interstitial|..|Vf (protein)" id="1647" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|ColonTransversum|Interstitial|..|Vf (water)" id="1648" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|Aciclovir|Concentration" id="1649" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|ColonTransversum|Interstitial|Aciclovir|Concentration" id="1650" />
+          <Map s="Sim|Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Aciclovir|P*SA interstitial -&gt; intracellular" id="1651" />
+          <Map s="Sim|Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Aciclovir|P*SA intracellular -&gt; interstitial" id="1652" />
+          <Map s="Sim|Organism|Lumen|ColonTransversum|Effective surface area" id="1653" />
+          <Map s="Sim|Organism|Lumen|ColonTransversum|Microvilli factor" id="1654" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|ColonTransversum|BloodCells|Aciclovir|Concentration" id="1655" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|ColonTransversum|Plasma|Aciclovir|Concentration" id="1656" />
+          <Map s="Sim|Neighborhoods|ColonTransversum_pls_ColonTransversum_bc|Surface area (blood cells/plasma)" id="1657" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|ColonTransversum|Plasma|..|Fraction vascular" id="1658" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|ColonTransversum|Plasma|..|Volume" id="1659" />
+          <Map s="Sim|Neighborhoods|ColonTransversum_pls_ColonTransversum_int|Aciclovir|P (plasma&lt;-&gt;interstitial)" id="1660" />
+          <Map s="Sim|Neighborhoods|ColonTransversum_pls_ColonTransversum_int|Aciclovir|Partition coefficient (interstitial/plasma)" id="1661" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|ColonDescendens|Interstitial|..|Vf (lipid)" id="1662" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|ColonDescendens|Interstitial|..|Vf (protein)" id="1663" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|ColonDescendens|Interstitial|..|Vf (water)" id="1664" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|Aciclovir|Concentration" id="1665" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|ColonDescendens|Interstitial|Aciclovir|Concentration" id="1666" />
+          <Map s="Sim|Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Aciclovir|P*SA interstitial -&gt; intracellular" id="1667" />
+          <Map s="Sim|Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Aciclovir|P*SA intracellular -&gt; interstitial" id="1668" />
+          <Map s="Sim|Organism|Lumen|ColonDescendens|Effective surface area" id="1669" />
+          <Map s="Sim|Organism|Lumen|ColonDescendens|Microvilli factor" id="1670" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|ColonDescendens|BloodCells|Aciclovir|Concentration" id="1671" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|ColonDescendens|Plasma|Aciclovir|Concentration" id="1672" />
+          <Map s="Sim|Neighborhoods|ColonDescendens_pls_ColonDescendens_bc|Surface area (blood cells/plasma)" id="1673" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|ColonDescendens|Plasma|..|Fraction vascular" id="1674" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|ColonDescendens|Plasma|..|Volume" id="1675" />
+          <Map s="Sim|Neighborhoods|ColonDescendens_pls_ColonDescendens_int|Aciclovir|P (plasma&lt;-&gt;interstitial)" id="1676" />
+          <Map s="Sim|Neighborhoods|ColonDescendens_pls_ColonDescendens_int|Aciclovir|Partition coefficient (interstitial/plasma)" id="1677" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|ColonSigmoid|Interstitial|..|Vf (lipid)" id="1678" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|ColonSigmoid|Interstitial|..|Vf (protein)" id="1679" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|ColonSigmoid|Interstitial|..|Vf (water)" id="1680" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|Aciclovir|Concentration" id="1681" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|ColonSigmoid|Interstitial|Aciclovir|Concentration" id="1682" />
+          <Map s="Sim|Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Aciclovir|P*SA interstitial -&gt; intracellular" id="1683" />
+          <Map s="Sim|Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Aciclovir|P*SA intracellular -&gt; interstitial" id="1684" />
+          <Map s="Sim|Organism|Lumen|ColonSigmoid|Effective surface area" id="1685" />
+          <Map s="Sim|Organism|Lumen|ColonSigmoid|Microvilli factor" id="1686" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|ColonSigmoid|BloodCells|Aciclovir|Concentration" id="1687" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|ColonSigmoid|Plasma|Aciclovir|Concentration" id="1688" />
+          <Map s="Sim|Neighborhoods|ColonSigmoid_pls_ColonSigmoid_bc|Surface area (blood cells/plasma)" id="1689" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|ColonSigmoid|Plasma|..|Fraction vascular" id="1690" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|ColonSigmoid|Plasma|..|Volume" id="1691" />
+          <Map s="Sim|Neighborhoods|ColonSigmoid_pls_ColonSigmoid_int|Aciclovir|P (plasma&lt;-&gt;interstitial)" id="1692" />
+          <Map s="Sim|Neighborhoods|ColonSigmoid_pls_ColonSigmoid_int|Aciclovir|Partition coefficient (interstitial/plasma)" id="1693" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|Rectum|Interstitial|..|Vf (lipid)" id="1694" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|Rectum|Interstitial|..|Vf (protein)" id="1695" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|Rectum|Interstitial|..|Vf (water)" id="1696" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|Rectum|Interstitial|Aciclovir|Concentration" id="1697" />
+          <Map s="Sim|Neighborhoods|Rectum_int_Rectum_cell|Aciclovir|P*SA interstitial -&gt; intracellular" id="1698" />
+          <Map s="Sim|Neighborhoods|Rectum_int_Rectum_cell|Aciclovir|P*SA intracellular -&gt; interstitial" id="1699" />
+          <Map s="Sim|Organism|Lumen|Rectum|Microvilli factor" id="1700" />
+          <Map s="Sim|Neighborhoods|Rectum_pls_Rectum_bc|Surface area (blood cells/plasma)" id="1701" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|Rectum|Plasma|..|Fraction vascular" id="1702" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|Rectum|Plasma|..|Volume" id="1703" />
+          <Map s="Sim|Neighborhoods|Rectum_pls_Rectum_int|Aciclovir|P (plasma&lt;-&gt;interstitial)" id="1704" />
+          <Map s="Sim|Neighborhoods|Rectum_pls_Rectum_int|Aciclovir|Partition coefficient (interstitial/plasma)" id="1705" />
+          <Map s="Sim|Organism|Lumen|Duodenum|Aciclovir|Effective concentration in lumen" id="1706" />
+          <Map s="Sim|Organism|Lumen|Duodenum|..|Paracellular absorption sink condition" id="1707" />
+          <Map s="Sim|Neighborhoods|Lumen_duo_Duodenum_pls|Aciclovir|DrugAbsorption_para|ProcessRate" id="1708" />
+          <Map s="Sim|Neighborhoods|Lumen_duo_Duodenum_pls|Aciclovir|Drug absorption rate (lumen to mucosa)" id="1709" />
+          <Map s="Sim|Neighborhoods|Lumen_duo_Duodenum_cell|Aciclovir|P_int_trans_cell_lum_factor" id="1710" />
+          <Map s="Sim|Neighborhoods|Lumen_duo_Duodenum_cell|Aciclovir|P_int_trans_lum_cell_factor" id="1711" />
+          <Map s="Sim|Organism|Lumen|Duodenum|..|Transcellular absorption sink condition" id="1712" />
+          <Map s="Sim|Neighborhoods|Duodenum_int_Duodenum_cell|Aciclovir|Partition coefficient (intracellular/plasma)" id="1713" />
+          <Map s="Sim|Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|pH" id="1714" />
+          <Map s="Sim|Organism|Lumen|Duodenum|pH" id="1715" />
+          <Map s="Sim|Neighborhoods|Lumen_duo_Duodenum_cell|Aciclovir|DrugAbsorption_trans|ProcessRate" id="1716" />
+          <Map s="Sim|Neighborhoods|Lumen_duo_Duodenum_cell|Aciclovir|Drug absorption rate (lumen to mucosa)" id="1717" />
+          <Map s="Sim|Neighborhoods|Duodenum_pls_PortalVein_pls|Aciclovir|Mass transfer rate (mucosa to portal vein plasma)" id="1718" />
+          <Map s="Sim|Neighborhoods|Duodenum_bc_PortalVein_bc|Aciclovir|Mass transfer rate (mucosa to portal vein blood cells)" id="1719" />
+          <Map s="Sim|Organism|Lumen|Caecum|Aciclovir|Effective concentration in lumen" id="1720" />
+          <Map s="Sim|Organism|Lumen|Caecum|..|Paracellular absorption sink condition" id="1721" />
+          <Map s="Sim|Neighborhoods|Lumen_cae_Caecum_cell|Aciclovir|P_int_trans_cell_lum_factor" id="1722" />
+          <Map s="Sim|Neighborhoods|Lumen_cae_Caecum_cell|Aciclovir|P_int_trans_lum_cell_factor" id="1723" />
+          <Map s="Sim|Organism|Lumen|Caecum|..|Transcellular absorption sink condition" id="1724" />
+          <Map s="Sim|Neighborhoods|Caecum_int_Caecum_cell|Aciclovir|Partition coefficient (intracellular/plasma)" id="1725" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|Caecum|Intracellular|pH" id="1726" />
+          <Map s="Sim|Organism|Lumen|Caecum|pH" id="1727" />
+          <Map s="Sim|Neighborhoods|Lumen_cae_Caecum_cell|Aciclovir|DrugAbsorption_trans|ProcessRate" id="1728" />
+          <Map s="Sim|Neighborhoods|Lumen_cae_Caecum_cell|Aciclovir|Drug absorption rate (lumen to mucosa)" id="1729" />
+          <Map s="Sim|Neighborhoods|Caecum_pls_PortalVein_pls|Aciclovir|Mass transfer rate (mucosa to portal vein plasma)" id="1730" />
+          <Map s="Sim|Neighborhoods|Caecum_bc_PortalVein_bc|Aciclovir|Mass transfer rate (mucosa to portal vein blood cells)" id="1731" />
+          <Map s="Sim|Organism|Lumen|ColonAscendens|Aciclovir|Effective concentration in lumen" id="1732" />
+          <Map s="Sim|Organism|Lumen|ColonAscendens|..|Paracellular absorption sink condition" id="1733" />
+          <Map s="Sim|Neighborhoods|Lumen_colasc_ColonAscendens_cell|Aciclovir|P_int_trans_cell_lum_factor" id="1734" />
+          <Map s="Sim|Neighborhoods|Lumen_colasc_ColonAscendens_cell|Aciclovir|P_int_trans_lum_cell_factor" id="1735" />
+          <Map s="Sim|Organism|Lumen|ColonAscendens|..|Transcellular absorption sink condition" id="1736" />
+          <Map s="Sim|Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Aciclovir|Partition coefficient (intracellular/plasma)" id="1737" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|pH" id="1738" />
+          <Map s="Sim|Organism|Lumen|ColonAscendens|pH" id="1739" />
+          <Map s="Sim|Neighborhoods|Lumen_colasc_ColonAscendens_cell|Aciclovir|DrugAbsorption_trans|ProcessRate" id="1740" />
+          <Map s="Sim|Neighborhoods|Lumen_colasc_ColonAscendens_cell|Aciclovir|Drug absorption rate (lumen to mucosa)" id="1741" />
+          <Map s="Sim|Neighborhoods|ColonAscendens_pls_PortalVein_pls|Aciclovir|Mass transfer rate (mucosa to portal vein plasma)" id="1742" />
+          <Map s="Sim|Neighborhoods|ColonAscendens_bc_PortalVein_bc|Aciclovir|Mass transfer rate (mucosa to portal vein blood cells)" id="1743" />
+          <Map s="Sim|Organism|Lumen|ColonTransversum|Aciclovir|Effective concentration in lumen" id="1744" />
+          <Map s="Sim|Organism|Lumen|ColonTransversum|..|Paracellular absorption sink condition" id="1745" />
+          <Map s="Sim|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|Aciclovir|P_int_trans_cell_lum_factor" id="1746" />
+          <Map s="Sim|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|Aciclovir|P_int_trans_lum_cell_factor" id="1747" />
+          <Map s="Sim|Organism|Lumen|ColonTransversum|..|Transcellular absorption sink condition" id="1748" />
+          <Map s="Sim|Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Aciclovir|Partition coefficient (intracellular/plasma)" id="1749" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|pH" id="1750" />
+          <Map s="Sim|Organism|Lumen|ColonTransversum|pH" id="1751" />
+          <Map s="Sim|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|Aciclovir|DrugAbsorption_trans|ProcessRate" id="1752" />
+          <Map s="Sim|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|Aciclovir|Drug absorption rate (lumen to mucosa)" id="1753" />
+          <Map s="Sim|Neighborhoods|ColonTransversum_pls_PortalVein_pls|Aciclovir|Mass transfer rate (mucosa to portal vein plasma)" id="1754" />
+          <Map s="Sim|Neighborhoods|ColonTransversum_bc_PortalVein_bc|Aciclovir|Mass transfer rate (mucosa to portal vein blood cells)" id="1755" />
+          <Map s="Sim|Organism|Lumen|ColonDescendens|Aciclovir|Effective concentration in lumen" id="1756" />
+          <Map s="Sim|Organism|Lumen|ColonDescendens|..|Paracellular absorption sink condition" id="1757" />
+          <Map s="Sim|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|Aciclovir|P_int_trans_cell_lum_factor" id="1758" />
+          <Map s="Sim|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|Aciclovir|P_int_trans_lum_cell_factor" id="1759" />
+          <Map s="Sim|Organism|Lumen|ColonDescendens|..|Transcellular absorption sink condition" id="1760" />
+          <Map s="Sim|Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Aciclovir|Partition coefficient (intracellular/plasma)" id="1761" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|pH" id="1762" />
+          <Map s="Sim|Organism|Lumen|ColonDescendens|pH" id="1763" />
+          <Map s="Sim|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|Aciclovir|DrugAbsorption_trans|ProcessRate" id="1764" />
+          <Map s="Sim|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|Aciclovir|Drug absorption rate (lumen to mucosa)" id="1765" />
+          <Map s="Sim|Neighborhoods|ColonDescendens_pls_PortalVein_pls|Aciclovir|Mass transfer rate (mucosa to portal vein plasma)" id="1766" />
+          <Map s="Sim|Neighborhoods|ColonDescendens_bc_PortalVein_bc|Aciclovir|Mass transfer rate (mucosa to portal vein blood cells)" id="1767" />
+          <Map s="Sim|Organism|Lumen|ColonSigmoid|Aciclovir|Effective concentration in lumen" id="1768" />
+          <Map s="Sim|Organism|Lumen|ColonSigmoid|..|Paracellular absorption sink condition" id="1769" />
+          <Map s="Sim|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|Aciclovir|P_int_trans_cell_lum_factor" id="1770" />
+          <Map s="Sim|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|Aciclovir|P_int_trans_lum_cell_factor" id="1771" />
+          <Map s="Sim|Organism|Lumen|ColonSigmoid|..|Transcellular absorption sink condition" id="1772" />
+          <Map s="Sim|Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Aciclovir|Partition coefficient (intracellular/plasma)" id="1773" />
+          <Map s="Sim|Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|pH" id="1774" />
+          <Map s="Sim|Organism|Lumen|ColonSigmoid|pH" id="1775" />
+          <Map s="Sim|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|Aciclovir|DrugAbsorption_trans|ProcessRate" id="1776" />
+          <Map s="Sim|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|Aciclovir|Drug absorption rate (lumen to mucosa)" id="1777" />
+          <Map s="Sim|Neighborhoods|ColonSigmoid_pls_PortalVein_pls|Aciclovir|Mass transfer rate (mucosa to portal vein plasma)" id="1778" />
+          <Map s="Sim|Neighborhoods|ColonSigmoid_bc_PortalVein_bc|Aciclovir|Mass transfer rate (mucosa to portal vein blood cells)" id="1779" />
+          <Map s="Sim|Organism|Liver|Periportal|Plasma|..|Blood flow rate" id="1780" />
+          <Map s="Sim|Organism|PortalVein|Blood flow rate" id="1781" />
+          <Map s="Q_pve" id="1782" />
+          <Map s="Sim|Organism|Liver|Periportal|BloodCells|..|Blood flow rate" id="1783" />
+          <Map s="Sim|Organism|PortalVein|BloodCells|..|Blood flow rate" id="1784" />
+          <Map s="Sim|Organism|PortalVein|Plasma|..|Blood flow rate" id="1785" />
+          <Map s="Sim|Organism|Liver|Pericentral|BloodCells|..|Blood flow rate" id="1786" />
+          <Map s="Sim|Organism|Liver|Pericentral|Plasma|..|Blood flow rate" id="1787" />
+          <Map s="Sim|Aciclovir|Calculated specific intestinal permeability (transcellular)" id="1788" />
+          <Map s="P_int_InVitro" id="1789" />
+          <Map s="Sim|Aciclovir|Parameter b for correlation of intestinal permeability (transcellular)" id="1790" />
+          <Map s="b" id="1791" />
+          <Map s="Sim|Aciclovir|Parameter m for correlation of intestinal permeability (transcellular)" id="1792" />
+          <Map s="m" id="1793" />
+          <Map s="Sim|Aciclovir|Specific intestinal permeability (transcellular)" id="1794" />
+          <Map s="..|Default Intestinal permeability (transcellular)" id="1795" />
+          <Map s="P_int_trans_default" id="1796" />
+          <Map s="..|Intestinal permeability (transcellular)" id="1797" />
+          <Map s="Sim|Aciclovir|P_bc_pls_factor" id="1798" />
+          <Map s="P_rbc_pls_factor" id="1799" />
+          <Map s="Sim|Aciclovir|P_pls_bc_factor" id="1800" />
+          <Map s="P_pls_rbc_factor" id="1801" />
+          <Map s="Sim|Organism|Vf (lipid, blood cells)" id="1802" />
+          <Map s="f_lipids_rbc" id="1803" />
+          <Map s="Sim|Organism|Vf (protein,blood cells)" id="1804" />
+          <Map s="f_proteins_rbc" id="1805" />
+          <Map s="Sim|Organism|Vf (water,blood cells)" id="1806" />
+          <Map s="f_water_rbc" id="1807" />
+          <Map s="..|BP_AGP" id="1808" />
+          <Map s="Agp" id="1809" />
+          <Map s="..|BP_ALBUMIN" id="1810" />
+          <Map s="Albumin" id="1811" />
+          <Map s="..|Fraction unbound (plasma, reference value)" id="1812" />
+          <Map s="fu_ref" id="1813" />
+          <Map s="..|Plasma protein binding partner" id="1814" />
+          <Map s="BindingPartner" id="1815" />
+          <Map s="Sim|Organism|Ontogeny factor (albumin)" id="1816" />
+          <Map s="AlbuminOntgenyFactor" id="1817" />
+          <Map s="Sim|Organism|Ontogeny factor (alpha1-acid glycoprotein)" id="1818" />
+          <Map s="AgpOntogenyFactor" id="1819" />
+          <Map s="Sim|Organism|Plasma protein scale factor" id="1820" />
+          <Map s="PlasmaProteinScaleFactor" id="1821" />
+          <Map s="LogP" id="1822" />
+          <Map s="..|Effective molecular weight" id="1823" />
+          <Map s="MWEff" id="1824" />
+          <Map s="..|Is small molecule" id="1825" />
+          <Map s="IsSmallMolecule" id="1826" />
+          <Map s="..|Lipophilicity" id="1827" />
+          <Map s="..|Br" id="1828" />
+          <Map s="Br" id="1829" />
+          <Map s="..|Cl" id="1830" />
+          <Map s="Cl" id="1831" />
+          <Map s="..|F" id="1832" />
+          <Map s="F" id="1833" />
+          <Map s="..|I" id="1834" />
+          <Map s="I" id="1835" />
+          <Map s="..|Molecular weight" id="1836" />
+          <Map s="Chlor" id="1837" />
+          <Map s="..|pKa_Acids_Count" id="1838" />
+          <Map s="pKa_Acids_Count" id="1839" />
+          <Map s="..|pKa_Bases_Count" id="1840" />
+          <Map s="pKa_Bases_Count" id="1841" />
+          <Map s="..|Compound type 0" id="1842" />
+          <Map s="CT_0" id="1843" />
+          <Map s="..|Compound type 1" id="1844" />
+          <Map s="CT_1" id="1845" />
+          <Map s="..|Compound type 2" id="1846" />
+          <Map s="CT_2" id="1847" />
+          <Map s="..|pKa value 0" id="1848" />
+          <Map s="..|pKa value 1" id="1849" />
+          <Map s="..|pKa value 2" id="1850" />
+          <Map s="..|pKa_OneAcid_0" id="1851" />
+          <Map s="pKa_OneAcid_0" id="1852" />
+          <Map s="..|pKa_ThreeAcids_0" id="1853" />
+          <Map s="pKa_ThreeAcids_0" id="1854" />
+          <Map s="..|pKa_TwoAcids_0" id="1855" />
+          <Map s="pKa_TwoAcids_0" id="1856" />
+          <Map s="..|pKa_ThreeAcids_1" id="1857" />
+          <Map s="pKa_ThreeAcids_1" id="1858" />
+          <Map s="..|pKa_TwoAcids_1" id="1859" />
+          <Map s="pKa_TwoAcids_1" id="1860" />
+          <Map s="..|Is triprotic acid" id="1861" />
+          <Map s="IsTriproticAcid" id="1862" />
+          <Map s="..|CT_ACID" id="1863" />
+          <Map s="CT_ACID" id="1864" />
+          <Map s="..|pKa_OneBase_0" id="1865" />
+          <Map s="pKa_OneBase_0" id="1866" />
+          <Map s="..|pKa_ThreeBases_0" id="1867" />
+          <Map s="pKa_ThreeBases_0" id="1868" />
+          <Map s="..|pKa_TwoBases_0" id="1869" />
+          <Map s="pKa_TwoBases_0" id="1870" />
+          <Map s="..|pKa_ThreeBases_1" id="1871" />
+          <Map s="pKa_ThreeBases_1" id="1872" />
+          <Map s="..|pKa_TwoBases_1" id="1873" />
+          <Map s="pKa_TwoBases_1" id="1874" />
+          <Map s="..|Is triprotic base" id="1875" />
+          <Map s="IsTriproticBase" id="1876" />
+          <Map s="..|CT_BASE" id="1877" />
+          <Map s="CT_BASE" id="1878" />
+          <Map s="..|CT_NEUTRAL" id="1879" />
+          <Map s="..|Reference pH" id="1880" />
+          <Map s="..|pKa_pH_WS_sol_F1" id="1881" />
+          <Map s="..|pKa_pH_WS_sol_F2" id="1882" />
+          <Map s="..|pKa_pH_WS_sol_F3" id="1883" />
+          <Map s="..|pKa_Acid_0" id="1884" />
+          <Map s="pKa_Acid_0" id="1885" />
+          <Map s="..|pKa_Acid_2" id="1886" />
+          <Map s="pKa_Acid_2" id="1887" />
+          <Map s="..|pKa_Base_0" id="1888" />
+          <Map s="pKa_Base_0" id="1889" />
+          <Map s="..|pKa_Base_2" id="1890" />
+          <Map s="pKa_Base_2" id="1891" />
+          <Map s="..|Solubility gain per charge" id="1892" />
+          <Map s="..|pKa_pH_WS_sol_K1" id="1893" />
+          <Map s="..|pKa_pH_WS_sol_K2" id="1894" />
+          <Map s="..|pKa_pH_WS_sol_K3" id="1895" />
+          <Map s="..|pKa_pH_WS_sol_K4" id="1896" />
+          <Map s="..|pKa_pH_WS_sol_K5" id="1897" />
+          <Map s="..|pKa_pH_WS_sol_K6" id="1898" />
+          <Map s="..|pKa_pH_WS_sol_K7" id="1899" />
+          <Map s="..|pKa_pH_WS_sol_K8" id="1900" />
+          <Map s="Sim|Applications|IV|Application_1|ProtocolSchemaItem|DrugMass" id="1901" />
+          <Map s="Sim|Applications|IV|Application_2|ProtocolSchemaItem|DrugMass" id="1902" />
+          <Map s="Sim|Applications|IV|Application_3|ProtocolSchemaItem|DrugMass" id="1903" />
+          <Map s="..|..|ProtocolSchemaItem|DrugMass" id="1904" />
+          <Map s="DrugMass" id="1905" />
+          <Map s="..|ProtocolSchemaItem|Start time" id="1906" />
+          <Map s="StartTime" id="1907" />
+          <Map s="..|DosePerBodyWeight" id="1908" />
+          <Map s="DosePerBodyWeight" id="1909" />
+          <Map s="Dose per body weight" id="1910" />
+          <Map s="..|Dose" id="1911" />
+          <Map s="Dose" id="1912" />
+          <Map s="..|ProtocolSchemaItem|DrugMass" id="1913" />
+        </StringMap>
+      </FormulaCache>
+    </Model>
+    <Creation createdAt="5248777815081568042" createdBy="Michael" creationMode="New" origin="PKSim" version="9.0" internalVersion="77" />
+  </Simulation>
+  <Favorites />
+</SimulationTransfer>
\ No newline at end of file
diff --git a/tests/MoBi.Tests/TestFiles/SimpleProject_341.mbp3 b/tests/MoBi.Tests/TestFiles/SimpleProject_341.mbp3
deleted file mode 100644
index 2a50b7755..000000000
Binary files a/tests/MoBi.Tests/TestFiles/SimpleProject_341.mbp3 and /dev/null differ
diff --git a/tests/MoBi.Tests/TestFiles/run.pkml b/tests/MoBi.Tests/TestFiles/run.pkml
index 63c78e82b..69ecbcc01 100644
--- a/tests/MoBi.Tests/TestFiles/run.pkml
+++ b/tests/MoBi.Tests/TestFiles/run.pkml
@@ -1,22 +1,15 @@
 <?xml version="1.0" encoding="utf-8"?>
-<SimulationTransfer id="QuXdylgfOkWCqQHuPeXQcw" reactionDimensionMode="AmountBased" version="7" modelLicences="" cs="BF43642B">
-  <Simulation id="7veUR00fRUGnL4mvgW_u6A" name="run">
+<SimulationTransfer id="NDAuWdZA0EC4k8XaiMBEJQ" reactionDimensionMode="AmountBased" version="12">
+  <Simulation id="7veUR00fRUGnL4mvgW_u6A" name="run" icon="Simulation">
     <BuildConfiguration>
-      <SpatialStructureInfo templateBuildingBlockId="94ad7f2b-054e-49ec-99a3-7275dc0143c3" simulationChanges="0" />
-      <MoleculesInfo templateBuildingBlockId="1e6ae288-bd1c-45ba-8d3c-47d5677ac010" simulationChanges="0" />
-      <ReactionsInfo templateBuildingBlockId="8d67039c-d8dd-41ec-82da-f60057a7b28c" simulationChanges="0" />
-      <PassiveTransportsInfo templateBuildingBlockId="321b693e-86b0-461d-b27d-a00969c0e88d" simulationChanges="0" />
-      <ObserversInfo templateBuildingBlockId="c05ba848-c12d-40e8-80cc-bfbc16438e4f" simulationChanges="0" />
-      <EventGroupsInfo templateBuildingBlockId="4c60389f-d779-45bd-a6ff-c7c96cc97da0" simulationChanges="0" />
-      <ParameterStartValuesInfo templateBuildingBlockId="c41dda3a-953d-4f36-a228-44580f8547ca" simulationChanges="0" />
-      <MoleculeStartValuesInfo templateBuildingBlockId="7484a397-903d-4e62-8d76-851909e3081b" simulationChanges="0" />
-      <SimulationSettingsInfo templateBuildingBlockId="949282de-5b2d-40ee-9b73-287d5d181d5f" simulationChanges="0" />
-      <Molecules id="c302e3fc-7be9-43ac-a6c1-6dc179cb63d3" name="Molecules" icon="Molecule" bbVersion="3">
+      <Molecules id="83ceb073-7909-48f6-9e95-4593bda576e2" name="Molecules" icon="Molecule" bbVersion="3">
+        <Creation createdAt="5248846165142554626" createdBy="Michael" creationMode="New" origin="Other" />
         <Builders>
-          <MoleculeBuilder id="749ed459-a958-4ee5-8cbd-4a002195ff16" name="dummy" icon="DRUG" mode="Logical" containerType="Other" isFloating="0" quantityType="Drug" isXenobiotic="1" dim="Concentration (molar)" defaultStartFormula="4d3d1edf-aabd-4414-9fc1-1d11151b481f" displayUnit="µmol/l">
+          <MoleculeBuilder id="12879703-d538-443d-a021-a94ad6f53534" name="dummy" icon="DRUG" mode="Logical" containerType="Other" isFloating="0" quantityType="Drug" isXenobiotic="1" dim="Concentration (molar)" defaultStartFormula="779c77be-8970-4246-bb08-5f53b241d94d" displayUnit="µmol/l">
             <Children>
-              <Parameter id="c19021c6-0954-4588-9e5e-bfdcdb2ebd81" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="81669ca6-3b2d-4b96-8751-acdf840881aa" displayUnit="µmol/l">
+              <Parameter id="16bb1dfc-11ea-4151-b3c3-379c48a84184" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="a8e2f571-7320-42f7-a61e-953713646877" displayUnit="µmol/l">
                 <Info flag="14" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
             </Children>
             <UsedCalculationMethods>
@@ -28,13 +21,13 @@
         </Builders>
         <FormulaCache>
           <Formulas>
-            <Formula id="81669ca6-3b2d-4b96-8751-acdf840881aa" name="ConcFormula" dim="Concentration (molar)" formula="V&gt;0 ? M/V : 0">
+            <Formula id="a8e2f571-7320-42f7-a61e-953713646877" name="ConcFormula" dim="Concentration (molar)" formula="V&gt;0 ? M/V : 0">
               <Paths>
                 <Path path="0" as="1" dim="2" />
                 <Path path="3" as="4" dim="5" />
               </Paths>
             </Formula>
-            <ConstantFormula id="4d3d1edf-aabd-4414-9fc1-1d11151b481f" dim="Concentration (molar)" value="0" />
+            <ConstantFormula id="779c77be-8970-4246-bb08-5f53b241d94d" dim="Concentration (molar)" value="0" />
           </Formulas>
           <StringMap>
             <Map s=".." id="0" />
@@ -46,107 +39,119 @@
           </StringMap>
         </FormulaCache>
       </Molecules>
-      <Observers id="a6d1f32f-184f-47d3-bd20-97c8fcce05bd" name="Observer" icon="Observer" bbVersion="0">
-        <FormulaCache>
-          <StringMap />
-        </FormulaCache>
+      <Observers id="766411f6-2642-4118-9cde-27b0f7369f11" name="Observer" icon="Observer" bbVersion="0">
+        <Creation createdAt="5248846165142644384" createdBy="Michael" creationMode="New" origin="Other" />
       </Observers>
-      <EventGroups id="7b044c29-31c5-49b6-a3ea-5b46d95041b5" name="Events" icon="EventGroup" bbVersion="0">
-        <FormulaCache>
-          <StringMap />
-        </FormulaCache>
+      <EventGroups id="d8f04a92-6d0e-4e39-8075-2cfadddcd3ad" name="Events" icon="EventGroup" bbVersion="0">
+        <Creation createdAt="5248846165142654358" createdBy="Michael" creationMode="New" origin="Other" />
       </EventGroups>
-      <PassiveTransports id="38f7ba33-4765-40d9-aee1-4dd44f9a2ca9" name="Passive Transports" icon="PassiveTransport" bbVersion="0">
-        <FormulaCache>
-          <StringMap />
-        </FormulaCache>
+      <PassiveTransports id="02ccf53d-236e-40f4-a2bc-a2a350a432a4" name="Passive Transports" icon="PassiveTransport" bbVersion="0">
+        <Creation createdAt="5248846165142664331" createdBy="Michael" creationMode="New" origin="Other" />
       </PassiveTransports>
-      <Reactions id="ff84e3cf-53d6-4164-9f0b-0e8152e73b83" name="Reaction" icon="Reaction" bbVersion="0">
-        <FormulaCache>
-          <StringMap />
-        </FormulaCache>
+      <Reactions id="60c238bc-b912-49c6-acea-34b6806d7e42" name="Reaction" icon="Reaction" bbVersion="0">
+        <Creation createdAt="5248846165142674304" createdBy="Michael" creationMode="New" origin="Other" />
       </Reactions>
-      <SpatialStructure id="999417dd-1ad5-4460-b510-899d93311539" name="Organism" icon="SpatialStructure" bbVersion="257">
-        <GlobalMoleculeDependentProperties id="39bae51f-f70d-4a50-997c-5e164fa7ca98" name="MoleculeProperties" mode="Logical" containerType="Molecule" />
+      <SpatialStructure id="49284eed-8d95-4442-a26d-36228e58d486" name="Organism" icon="SpatialStructure" bbVersion="254">
+        <Creation createdAt="5248846165143631745" createdBy="Michael" creationMode="New" origin="Other" />
+        <GlobalMoleculeDependentProperties id="34a9b389-5604-464a-9e1b-a6f67fc473f9" name="MoleculeProperties" mode="Logical" containerType="Molecule" />
         <TopContainers>
-          <Container id="1e347f08-7e05-409f-a001-bad3d8695948" name="Organism" icon="ORGANISM" mode="Physical" containerType="Organism">
+          <Container id="72dcfc2f-402c-48c6-abcd-6ded5b7adae7" name="Organism" icon="ORGANISM" mode="Physical" containerType="Organism">
             <Tags>
               <Tag value="Organism" />
             </Tags>
             <Children>
-              <Parameter id="83e01b02-05f3-4b1f-8466-04ba6ebdfaca" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" value="0.001" displayUnit="ml">
+              <Parameter id="20e7bc30-62aa-40a7-ae35-72d672f3ba8a" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" value="0.001" displayUnit="ml">
                 <Info flag="10" seq="1" ref="0" bb="2" group="65" />
+                <Origin />
               </Parameter>
-              <Container id="d21d7768-c0ff-40ec-bc00-4cf12799de56" name="MoleculeProperties" icon="CONTAINER" mode="Logical" containerType="Other" />
-              <Container id="8e7b68fc-b992-46f8-9b8a-524eaca11aca" name="LV" icon="CONTAINER" mode="Logical" containerType="Organ">
+              <Container id="140dae88-3115-45cf-ad84-9bdceec07537" name="MoleculeProperties" icon="CONTAINER" mode="Logical" containerType="Other" />
+              <Container id="e5bad610-e381-42ff-b7e3-96e6ebbb85de" name="LV" icon="CONTAINER" mode="Logical" containerType="Organ">
                 <Tags>
                   <Tag value="LV" />
                 </Tags>
                 <Children>
-                  <Container id="07c32b6a-e66a-4c74-9321-81504dc7c726" name="MoleculeProperties" mode="Logical" containerType="Other" />
-                  <Parameter id="06b5b515-aae1-4e75-8db4-aa7d228cce3b" name="Plv" icon="Parameter" persistable="1" isFixedValue="0" dim="Pressure" quantityType="Parameter" formula="35b7fac7-7439-4cf6-9e9c-18072b0a186a" displayUnit="Pa">
+                  <Container id="891c713f-028f-4273-b6a8-67da071ca922" name="MoleculeProperties" mode="Logical" containerType="Other" />
+                  <Parameter id="7b4aba37-f629-4757-a185-123a4af7a236" name="Plv" icon="Parameter" persistable="1" isFixedValue="0" dim="Pressure" quantityType="Parameter" negativeValuesAllowed="1" formula="f9cfbe10-e95e-4788-924f-b05f2209b79b" displayUnit="Pa">
                     <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+                    <Origin />
                   </Parameter>
-                  <Parameter id="78bffbbe-ba1d-4479-b0aa-d7f8cee470b9" name="Vlv" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" rHSFormula="8911e685-8970-4bce-b4ca-c00b1bab78e3" value="0.001" displayUnit="ml">
+                  <Parameter id="6736f58f-743f-40c9-aa94-a5645a094b84" name="Vlv" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" rHSFormula="4e860eb5-c648-4ea4-a790-ad9a1711353b" value="0.001" displayUnit="ml">
                     <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+                    <Origin />
                   </Parameter>
-                  <Parameter id="13b65d65-1082-49ee-8e96-c35a5651ec5a" name="Elv1" description="wave build up" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="95448d3d-efab-449f-93b5-e32c1a9779b1">
+                  <Parameter id="6224da98-60ec-450e-a85d-75c22d73efff" name="Elv1" description="wave build up" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="f36ac188-228c-42b1-a3ca-3c6f87bb395e">
                     <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+                    <Origin />
                   </Parameter>
-                  <Parameter id="3f5c9719-2133-4af9-8468-4f9668ddf553" name="Elv2" description="wave relaxation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="7eb2e480-b108-4391-80d2-d9529e73dc5d">
+                  <Parameter id="8a6bb6c1-1e95-4aa4-86bf-f96c738dcef2" name="Elv2" description="wave relaxation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ccb550e2-7985-437d-9a2b-6b648b0ff9cc">
                     <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+                    <Origin />
                   </Parameter>
-                  <Parameter id="4f095583-8e13-4801-a8f6-eac63ce19c0d" name="Elv" description="Elv" icon="Parameter" persistable="1" isFixedValue="0" quantityType="Parameter" formula="9b386e2d-f5a3-451b-9935-3bb0733dbf34">
+                  <Parameter id="c81a200d-6947-4cf3-9974-1e307067876f" name="Elv" description="Elv" icon="Parameter" persistable="1" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="606b892e-e7aa-416b-b4b7-de918cc748c4">
                     <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+                    <Origin />
                   </Parameter>
-                  <Parameter id="7a684865-d4db-4f5e-8821-7c8d81e22cf5" name="Peslv" icon="Parameter" persistable="0" isFixedValue="0" dim="Pressure" quantityType="Parameter" formula="1e16c1a6-e026-4a13-a786-241e028f5ecd" displayUnit="Pa">
+                  <Parameter id="de55c1c2-ffe7-4430-8393-3a6b981fe226" name="Peslv" icon="Parameter" persistable="0" isFixedValue="0" dim="Pressure" quantityType="Parameter" negativeValuesAllowed="1" formula="fa454ecd-8637-4fb4-8ae7-d113a5c25109" displayUnit="Pa">
                     <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+                    <Origin />
                   </Parameter>
-                  <Parameter id="28f87d22-15ec-4335-be86-011ff5e3cc7c" name="Pedlv" icon="Parameter" persistable="0" isFixedValue="0" dim="Pressure" quantityType="Parameter" formula="b432189d-0736-4410-8af3-0ef71aaad7fb" displayUnit="Pa">
+                  <Parameter id="2ea49733-c9ff-4b21-b4c2-ae146c6c6934" name="Pedlv" icon="Parameter" persistable="0" isFixedValue="0" dim="Pressure" quantityType="Parameter" negativeValuesAllowed="1" formula="a3f78798-3dc2-49ff-abdb-1af51eb2223b" displayUnit="Pa">
                     <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+                    <Origin />
                   </Parameter>
-                  <Parameter id="3cedeeb1-69de-4a0d-ab3f-67256e179947" name="bLV" description="valve" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="ff84e015-46b4-457d-b6b5-4abfa1d4cd36">
+                  <Parameter id="3ee3c0be-14ce-4de9-92c2-932736e01d1d" name="bLV" description="valve" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="06c2c5ac-12d4-4106-950f-e3050327e7b1">
                     <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+                    <Origin />
                   </Parameter>
-                  <Parameter id="5ea04414-2063-492a-a1af-b1afafc9d1b6" name="aLV" description="valve" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="7a8ca46d-eb03-4dcc-9c89-01b8b00818ab">
+                  <Parameter id="786d9fb6-028e-4542-a2bd-63002f860228" name="aLV" description="valve" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="6e58e1e8-3903-4f94-b86e-a3286d6a300c">
                     <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+                    <Origin />
                   </Parameter>
-                  <Parameter id="de359adc-57db-436c-bdeb-b4f7d5c0c844" name="V0lv" description="zero ventricular pressure" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" value="0.0001" displayUnit="ml">
+                  <Parameter id="0d2af54b-f840-4996-b276-c37ec2e9d2c4" name="V0lv" description="zero ventricular pressure" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" value="0.0001" displayUnit="ml">
                     <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+                    <Origin />
                   </Parameter>
-                  <Parameter id="08cb9153-b2e0-4c4b-a5fb-3f50cf912ec3" name="Rvp" description="Rvp" icon="Parameter" persistable="0" isFixedValue="0" dim="Resistance" quantityType="Parameter" value="6000" displayUnit="Pa*s/ml">
+                  <Parameter id="42ea6810-5699-44b4-80d0-3325196699d9" name="Rvp" description="Rvp" icon="Parameter" persistable="0" isFixedValue="0" dim="Resistance" quantityType="Parameter" negativeValuesAllowed="1" value="6000" displayUnit="Pa*s/ml">
                     <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+                    <Origin />
                   </Parameter>
-                  <Parameter id="153bc935-9b4e-4b32-bd3b-7e051dd487e7" name="Rcs" description="Rcs" icon="Parameter" persistable="0" isFixedValue="0" dim="Resistance" quantityType="Parameter" value="6000" displayUnit="Pa*s/ml">
+                  <Parameter id="d390f339-b27e-4cac-b7db-1f33eecd703e" name="Rcs" description="Rcs" icon="Parameter" persistable="0" isFixedValue="0" dim="Resistance" quantityType="Parameter" negativeValuesAllowed="1" value="6000" displayUnit="Pa*s/ml">
                     <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+                    <Origin />
                   </Parameter>
-                  <Parameter id="8c6113ff-7bef-49c2-97b8-801910933663" name="Pcvp" icon="Parameter" persistable="0" isFixedValue="0" dim="Pressure" quantityType="Parameter" value="360" displayUnit="Pa">
+                  <Parameter id="83993495-805f-4cd5-9a18-63db02ebe0a8" name="Pcvp" icon="Parameter" persistable="0" isFixedValue="0" dim="Pressure" quantityType="Parameter" negativeValuesAllowed="1" value="360" displayUnit="Pa">
                     <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+                    <Origin />
                   </Parameter>
-                  <Parameter id="57d5bb9f-dd75-47a2-8e6d-5cb5da053c10" name="Pcas" icon="Parameter" persistable="0" isFixedValue="0" dim="Pressure" quantityType="Parameter" value="360" displayUnit="Pa">
+                  <Parameter id="e0618da2-da32-455d-93e9-c0800d04a703" name="Pcas" icon="Parameter" persistable="0" isFixedValue="0" dim="Pressure" quantityType="Parameter" negativeValuesAllowed="1" value="360" displayUnit="Pa">
                     <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+                    <Origin />
                   </Parameter>
-                  <Parameter id="7dd04ff2-6555-482f-85a6-0cd49ee5127e" name="Eeslv" icon="Parameter" persistable="0" isFixedValue="0" dim="Elastance" quantityType="Parameter" value="360000" displayUnit="Pa/ml">
+                  <Parameter id="4888870e-2ec9-4412-966f-c17c309c4aeb" name="Eeslv" icon="Parameter" persistable="0" isFixedValue="0" dim="Elastance" quantityType="Parameter" negativeValuesAllowed="1" value="360000" displayUnit="Pa/ml">
                     <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+                    <Origin />
                   </Parameter>
-                  <Parameter id="83bb7407-0b1a-4dcc-910d-9791b5c62cde" name="Pcp" icon="Parameter" persistable="0" isFixedValue="0" dim="Pressure" quantityType="Parameter" value="360" displayUnit="Pa">
+                  <Parameter id="38e417f2-dd34-4248-924c-bfa256e13ba8" name="Pcp" icon="Parameter" persistable="0" isFixedValue="0" dim="Pressure" quantityType="Parameter" negativeValuesAllowed="1" value="360" displayUnit="Pa">
                     <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+                    <Origin />
                   </Parameter>
                 </Children>
               </Container>
-              <Parameter id="2e966763-07f1-4314-9047-05317e83ae7b" name="Tes" description="time of pulse build up" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" value="1" displayUnit="min">
+              <Parameter id="06002465-aa38-46cd-b152-4a94339731d7" name="Tes" description="time of pulse build up" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" value="1" displayUnit="min">
                 <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
-              <Parameter id="d5653d3a-9390-4917-a3a4-431704660d0a" name="tau" description="time of pulse relaxation" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" rHSFormula="5389a99c-1866-45bc-bdce-10e850dffac4" value="1" displayUnit="min">
+              <Parameter id="cc682ef7-774d-495a-af4c-2dbb4e3cd9c3" name="tau" description="time of pulse relaxation" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" value="1" displayUnit="min">
                 <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
             </Children>
           </Container>
         </TopContainers>
-        <NeighborhoodsContainer id="148287bf-625a-4a40-a332-4501f693fa50" name="Neighborhoods" mode="Logical" containerType="Other" />
+        <NeighborhoodsContainer id="cf6902b5-a98f-4f1d-985f-b41da8c04a8d" name="Neighborhoods" mode="Logical" containerType="Other" />
         <FormulaCache>
           <Formulas>
-            <Formula id="35b7fac7-7439-4cf6-9e9c-18072b0a186a" name="Plv" dim="Pressure" formula="(Peslv-Pedlv)*Elv+Pedlv">
+            <Formula id="f9cfbe10-e95e-4788-924f-b05f2209b79b" name="Plv" dim="Pressure" formula="(Peslv-Pedlv)*Elv+Pedlv">
               <Paths>
                 <Path path="0" as="1" />
                 <Path path="2" as="3" />
@@ -154,7 +159,7 @@
                 <Path path="2" as="6" />
               </Paths>
             </Formula>
-            <Formula id="8911e685-8970-4bce-b4ca-c00b1bab78e3" name="Vlv" dim="Volume per Time" formula="(Pcp-Plv)*aLV/Rvp-(Plv-Pcas)*bLV/Rcs">
+            <Formula id="4e860eb5-c648-4ea4-a790-ad9a1711353b" name="Vlv" dim="Flow" formula="(Pcp-Plv)*aLV/Rvp-(Plv-Pcas)*bLV/Rcs">
               <Paths>
                 <Path path="7" as="8" dim="9" />
                 <Path path="10" as="11" />
@@ -165,20 +170,20 @@
                 <Path path="21" as="22" dim="16" />
               </Paths>
             </Formula>
-            <Formula id="95448d3d-efab-449f-93b5-e32c1a9779b1" name="Elv1" formula="0.5*(sin(pi*Time/Tes-pi/2)+1)">
+            <Formula id="f36ac188-228c-42b1-a3ca-3c6f87bb395e" name="Elv1" formula="0.5*(sin(pi*Time/Tes-pi/2)+1)">
               <Paths>
                 <TimePath />
                 <Path path="23" as="24" dim="25" />
               </Paths>
             </Formula>
-            <Formula id="7eb2e480-b108-4391-80d2-d9529e73dc5d" name="Elv2" formula="0.5*exp(-(Time-3*Tes/2)/tau)">
+            <Formula id="ccb550e2-7985-437d-9a2b-6b648b0ff9cc" name="Elv2" formula="0.5*exp(-(Time-3*Tes/2)/tau)">
               <Paths>
                 <TimePath />
                 <Path path="23" as="24" dim="25" />
                 <Path path="26" as="27" dim="25" />
               </Paths>
             </Formula>
-            <Formula id="9b386e2d-f5a3-451b-9935-3bb0733dbf34" name="Elv" formula="Time &lt; 3*Tes/2 ? Elv1 : Elv2">
+            <Formula id="606b892e-e7aa-416b-b4b7-de918cc748c4" name="Elv" formula="Time &lt; 3*Tes/2 ? Elv1 : Elv2">
               <Paths>
                 <TimePath />
                 <Path path="28" as="29" />
@@ -186,32 +191,31 @@
                 <Path path="23" as="24" dim="25" />
               </Paths>
             </Formula>
-            <Formula id="1e16c1a6-e026-4a13-a786-241e028f5ecd" name="Peslv" dim="Pressure" formula="Eeslv*(Vlv-V0lv)">
+            <Formula id="fa454ecd-8637-4fb4-8ae7-d113a5c25109" name="Peslv" dim="Pressure" formula="Eeslv*(Vlv-V0lv)">
               <Paths>
                 <Path path="32" as="33" dim="34" />
                 <Path path="35" as="36" dim="34" />
                 <Path path="37" as="38" dim="16" />
               </Paths>
             </Formula>
-            <Formula id="b432189d-0736-4410-8af3-0ef71aaad7fb" name="Pedlv" dim="Pressure" formula="1*(exp((Vlv-V0lv))-1)">
+            <Formula id="a3f78798-3dc2-49ff-abdb-1af51eb2223b" name="Pedlv" dim="Pressure" formula="1*(exp((Vlv-V0lv))-1)">
               <Paths>
                 <Path path="32" as="33" dim="34" />
                 <Path path="35" as="36" dim="34" />
               </Paths>
             </Formula>
-            <Formula id="ff84e015-46b4-457d-b6b5-4abfa1d4cd36" name="bLV" formula="Plv &gt; Pcas ? 0 : 1">
+            <Formula id="06c2c5ac-12d4-4106-950f-e3050327e7b1" name="bLV" formula="Plv &gt; Pcas ? 0 : 1">
               <Paths>
                 <Path path="7" as="8" dim="39" />
                 <Path path="19" as="20" dim="39" />
               </Paths>
             </Formula>
-            <Formula id="7a8ca46d-eb03-4dcc-9c89-01b8b00818ab" name="aLV" formula="Plv &lt; Pcvp ? 1 : 0">
+            <Formula id="6e58e1e8-3903-4f94-b86e-a3286d6a300c" name="aLV" formula="Plv &lt; Pcvp ? 1 : 0">
               <Paths>
                 <Path path="7" as="8" dim="9" />
                 <Path path="40" as="41" dim="16" />
               </Paths>
             </Formula>
-            <Formula id="5389a99c-1866-45bc-bdce-10e850dffac4" name="T1" dim="Time per Time" formula="0.1" />
           </Formulas>
           <StringMap>
             <Map s="Organism|LV|Peslv" id="0" />
@@ -223,7 +227,7 @@
             <Map s="Pedlv1" id="6" />
             <Map s="Organism|LV|Plv" id="7" />
             <Map s="Plv" id="8" />
-            <Map s="Volume per Time" id="9" />
+            <Map s="Flow" id="9" />
             <Map s="Organism|LV|aLV" id="10" />
             <Map s="aLV" id="11" />
             <Map s="Organism|LV|bLV" id="12" />
@@ -258,49 +262,41 @@
             <Map s="Pcvp" id="41" />
           </StringMap>
         </FormulaCache>
-        <DiagramModel IsLayouted="True">
-          <SimpleContainerNode Id="148287bf-625a-4a40-a332-4501f693fa50" Name="Neighborhoods" Location="-114.219711 -18.2822838" Size="116.899719 21.0911446" Hidden="false" IsVisible="false" LocationFixed="false" UserFlags="1" Description="Neighborhoods" IsLogical="true" IsExpanded="true" IsExpandedByDefault="false" />
-          <SimpleContainerNode Id="1e347f08-7e05-409f-a001-bad3d8695948" Name="Organism" Location="-51.26985 -9.282284" Size="180.049469 60.2734261" Hidden="false" IsVisible="true" LocationFixed="true" UserFlags="1" Description="Organism" IsLogical="false" IsExpanded="true" IsExpandedByDefault="true">
-            <SimpleContainerNode Id="d21d7768-c0ff-40ec-bc00-4cf12799de56" Name="MoleculeProperties" Location="-11.2698517 26.9000015" Size="142.049469 21.0911446" Hidden="false" IsVisible="false" LocationFixed="false" UserFlags="1" Description="MoleculeProperties" IsLogical="true" IsExpanded="true" IsExpandedByDefault="false" />
-            <SimpleContainerNode Id="8e7b68fc-b992-46f8-9b8a-524eaca11aca" Name="LV" Location="-31.2698517 8.808861" Size="157.049469 39.18228" Hidden="false" IsVisible="true" LocationFixed="false" UserFlags="1" Description="LV" IsLogical="true" IsExpanded="true" IsExpandedByDefault="false">
-              <SimpleContainerNode Id="07c32b6a-e66a-4c74-9321-81504dc7c726" Name="MoleculeProperties" Location="-16.2698517 26.9" Size="144.049469 25.0911446" Hidden="false" IsVisible="false" LocationFixed="false" UserFlags="1" Description="MoleculeProperties" IsLogical="true" IsExpanded="false" IsExpandedByDefault="false" />
-            </SimpleContainerNode>
-          </SimpleContainerNode>
-        </DiagramModel>
       </SpatialStructure>
-      <ParameterStartValues id="b3ec6645-a214-4ecf-baa6-84d916e3664a" name="init" icon="ParameterStartValues" bbVersion="1" spatialStructureId="94ad7f2b-054e-49ec-99a3-7275dc0143c3" moleculeBuildingBlockId="1e6ae288-bd1c-45ba-8d3c-47d5677ac010">
+      <ParameterStartValues id="f477b7f7-83d3-4f13-ac1f-50c48ed4050a" name="init" icon="ParameterStartValues" bbVersion="1" spatialStructureId="94ad7f2b-054e-49ec-99a3-7275dc0143c3" moleculeBuildingBlockId="1e6ae288-bd1c-45ba-8d3c-47d5677ac010">
+        <Creation createdAt="5248846165144270039" createdBy="Michael" creationMode="New" origin="Other" />
         <Builders>
-          <ParameterStartValue id="LOEPA0xlQ0GOfo85Bfqvxg" name="Vlv" dimension="Volume" startValue="0.001" displayUnit="ml">
+          <ParameterStartValue id="WLzWNZ_ZDUG1moFX6fIllQ" name="Vlv" dimension="Volume" startValue="0.001" displayUnit="ml">
             <ContainerPath path="0" />
           </ParameterStartValue>
-          <ParameterStartValue id="DBO_3EJhLUutCfTaz_jFaw" name="V0lv" dimension="Volume" startValue="0.0001" displayUnit="ml">
+          <ParameterStartValue id="vCZzMWbPX0-2GWmc2zDrtg" name="V0lv" dimension="Volume" startValue="0.0001" displayUnit="ml">
             <ContainerPath path="0" />
           </ParameterStartValue>
-          <ParameterStartValue id="wjm9RYtvgUK0XPcRFLNsOA" name="Rvp" dimension="Resistance" startValue="6000" displayUnit="Pa*s/ml">
+          <ParameterStartValue id="3QeB_Nfy8ku0k3VjzM9UlQ" name="Rvp" dimension="Resistance" startValue="6000" displayUnit="Pa*s/ml">
             <ContainerPath path="0" />
           </ParameterStartValue>
-          <ParameterStartValue id="nlq1EHRUNkqUo-5evu-jgg" name="Rcs" dimension="Resistance" startValue="6000" displayUnit="Pa*s/ml">
+          <ParameterStartValue id="zGFDkxyq8keUd7kxXmKW0Q" name="Rcs" dimension="Resistance" startValue="6000" displayUnit="Pa*s/ml">
             <ContainerPath path="0" />
           </ParameterStartValue>
-          <ParameterStartValue id="Vm0_M5aXx0CqhFz8n3it1w" name="Pcvp" dimension="Pressure" startValue="360" displayUnit="Pa">
+          <ParameterStartValue id="41A1V3CsBkuY94Q_elkLMA" name="Pcvp" dimension="Pressure" startValue="360" displayUnit="Pa">
             <ContainerPath path="0" />
           </ParameterStartValue>
-          <ParameterStartValue id="Qon-nAn1tE2KmG-R9PeDSg" name="Pcas" dimension="Pressure" startValue="360" displayUnit="Pa">
+          <ParameterStartValue id="lLJFm0XUKkqidmSEK4XKaQ" name="Pcas" dimension="Pressure" startValue="360" displayUnit="Pa">
             <ContainerPath path="0" />
           </ParameterStartValue>
-          <ParameterStartValue id="hR8T1GyNhECERyl_eH3meQ" name="Eeslv" dimension="Elastance" startValue="360000" displayUnit="Pa/ml">
+          <ParameterStartValue id="CxCwNIWr5EupgjkQusP1Iw" name="Eeslv" dimension="Elastance" startValue="360000" displayUnit="Pa/ml">
             <ContainerPath path="0" />
           </ParameterStartValue>
-          <ParameterStartValue id="3EcahJkslEOvuS3C_Auemg" name="Pcp" dimension="Pressure" startValue="360" displayUnit="Pa">
+          <ParameterStartValue id="u1ZOeQ8GM02AH0qHdu-b4w" name="Pcp" dimension="Pressure" startValue="360" displayUnit="Pa">
             <ContainerPath path="0" />
           </ParameterStartValue>
-          <ParameterStartValue id="1dWtqn-gl0ajhhb5DruWBA" name="Volume" dimension="Volume" startValue="1" displayUnit="l">
+          <ParameterStartValue id="tPvmdiWRxkqauN7gPs0rdQ" name="Volume" dimension="Volume" startValue="1" displayUnit="l">
             <ContainerPath path="1" />
           </ParameterStartValue>
-          <ParameterStartValue id="Ros5ptJPs0CXxV1VwrB_Bg" name="Tes" dimension="Time" startValue="1" displayUnit="min">
+          <ParameterStartValue id="KdsokmShqESOCLdkzzsJyQ" name="Tes" dimension="Time" startValue="1" displayUnit="min">
             <ContainerPath path="1" />
           </ParameterStartValue>
-          <ParameterStartValue id="5BkjJtCmLEWSGnEOO3EjDg" name="tau" dimension="Time" startValue="1" displayUnit="min">
+          <ParameterStartValue id="nvhJvruoE0Khc7_F2OvGqQ" name="tau" dimension="Time" startValue="1" displayUnit="min">
             <ContainerPath path="1" />
           </ParameterStartValue>
         </Builders>
@@ -311,9 +307,10 @@
           </StringMap>
         </FormulaCache>
       </ParameterStartValues>
-      <MoleculeStartValues id="04a96dc7-54df-49b0-adb9-5d924a924fa7" name="init" icon="MoleculeStartValues" bbVersion="0" spatialStructureId="94ad7f2b-054e-49ec-99a3-7275dc0143c3" moleculeBuildingBlockId="1e6ae288-bd1c-45ba-8d3c-47d5677ac010">
+      <MoleculeStartValues id="dc7adbb8-3513-424d-a18a-35fe60cec4d7" name="init" icon="MoleculeStartValues" bbVersion="0" spatialStructureId="94ad7f2b-054e-49ec-99a3-7275dc0143c3" moleculeBuildingBlockId="1e6ae288-bd1c-45ba-8d3c-47d5677ac010">
+        <Creation createdAt="5248846165144359819" createdBy="Michael" creationMode="New" origin="Other" />
         <Builders>
-          <MoleculeStartValue id="yL0Rel02e0q6u6JDz65GHw" name="dummy" dimension="Concentration (molar)" startValue="0" scaleDivisor="1" isPresent="1" displayUnit="µmol/l">
+          <MoleculeStartValue id="LyQtNJ2AIkC-MyefeMRAnA" name="dummy" dimension="Concentration (molar)" startValue="0" scaleDivisor="1" isPresent="1" negativeValuesAllowed="1" displayUnit="µmol/l">
             <ContainerPath path="0" />
           </MoleculeStartValue>
         </Builders>
@@ -323,20 +320,55 @@
           </StringMap>
         </FormulaCache>
       </MoleculeStartValues>
-      <SimulationSettings id="536ee4cd-266c-4590-b1de-444a6af6e82a" name="Simulation Settings" icon="SimulationSettings" bbVersion="7" randomSeed="95488539">
-        <Solver solverName="CVODE1002_2" absTol="1E-09" relTol="0.0001" h0="1E-10" hMax="60" hMin="0" mxStep="100000" useJacobian="1" />
-        <OutputSchema id="d8a00171-4e9a-4de0-ab9f-dc8a03b85ba3" name="Output schema" mode="Logical" containerType="Other">
+      <SimulationSettings id="3b278d6c-ef4a-4a5f-b0a6-fe33cec3507c" name="Simulation Settings" icon="SimulationSettings" bbVersion="7" randomSeed="598042125">
+        <Creation createdAt="5248846165144409711" createdBy="Michael" creationMode="New" origin="Other" />
+        <Solver id="jTu79rwfd0GbgM2cgcL2wQ" name="CVODE1002_2" mode="Logical" containerType="Other">
           <Children>
-            <OutputInterval id="9574c705-6b8c-479d-9dab-b79a612a0611" name="Output interval" mode="Logical" containerType="Other">
+            <Parameter id="RZqRPRc2TESH8EgmqzEdXw" name="Absolute tolerance" icon="PARAMETER" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" value="1E-09">
+              <Info flag="10" seq="1" ref="0" bb="2" group="100" />
+              <Origin />
+            </Parameter>
+            <Parameter id="5FJurM51J0-2HLvo3f7fZQ" name="Relative tolerance" icon="PARAMETER" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" value="0.0001">
+              <Info flag="10" seq="1" ref="0" bb="2" group="100" />
+              <Origin />
+            </Parameter>
+            <Parameter id="O5MtRCY5pk6_1mQTZHhbew" name="H0" icon="PARAMETER" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" value="1E-10">
+              <Info flag="10" seq="1" ref="0" bb="2" group="100" />
+              <Origin />
+            </Parameter>
+            <Parameter id="KkaFSZl5LUO9ZnZPGWH7GQ" name="HMax" icon="PARAMETER" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" value="60">
+              <Info flag="10" seq="1" ref="0" bb="2" group="100" />
+              <Origin />
+            </Parameter>
+            <Parameter id="zMXzEjjghEu84SvH6qzsew" name="HMin" icon="PARAMETER" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" value="0">
+              <Info flag="10" seq="1" ref="0" bb="2" group="100" />
+              <Origin />
+            </Parameter>
+            <Parameter id="eIAqWgCK5EetDlnuQrv_Qg" name="MxStep" icon="PARAMETER" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" value="100000">
+              <Info flag="10" seq="1" ref="0" bb="2" group="100" />
+              <Origin />
+            </Parameter>
+            <Parameter id="rAEyOyN8Zku_LK-LkdKt6g" name="Use Jacobian" icon="PARAMETER" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" value="1">
+              <Info flag="10" seq="1" ref="0" bb="2" group="100" />
+              <Origin />
+            </Parameter>
+          </Children>
+        </Solver>
+        <OutputSchema id="587af7ab-9cf6-404e-a65a-fef431a73db2" name="Output schema" mode="Logical" containerType="Other">
+          <Children>
+            <OutputInterval id="9f352b53-aed8-45c6-b2ae-5268b25676fb" name="Output interval" mode="Logical" containerType="Other">
               <Children>
-                <Parameter id="ac66e985-d8cf-4bb3-b3d9-b0954a5ac095" name="Start time" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" value="0" displayUnit="min">
+                <Parameter id="3635ed15-3582-42f7-b6ae-70c6cefe6e48" name="Start time" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" value="0" displayUnit="min">
                   <Info flag="8" seq="1" ref="0" bb="2" group="98" />
+                  <Origin />
                 </Parameter>
-                <Parameter id="34fee432-1db1-4993-aa63-6e1669df4ae5" name="End time" icon="Parameter" persistable="0" isFixedValue="1" dim="Time" quantityType="Parameter" formula="9443e33f-2afb-4cb8-8fb0-399949bad9f5" value="5" displayUnit="min">
+                <Parameter id="da7ff925-63d3-464a-9874-1f8949c926f2" name="End time" icon="Parameter" persistable="0" isFixedValue="1" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" formula="3ab6d85d-68e5-42d3-be59-8a61e5917615" value="5" displayUnit="min">
                   <Info flag="8" seq="1" ref="0" bb="2" group="98" />
+                  <Origin />
                 </Parameter>
-                <Parameter id="be2d4a41-2327-4b99-b4e0-6bd4adc76be5" name="Resolution" icon="Parameter" persistable="0" isFixedValue="1" dim="Resolution" quantityType="Parameter" formula="7a73986d-a5ed-45bf-9f79-31a14371a6c6" value="40" displayUnit="pts/min">
+                <Parameter id="3b7745be-7c9a-4283-96d5-4bb21a2b3804" name="Resolution" icon="Parameter" persistable="0" isFixedValue="1" dim="Resolution" quantityType="Parameter" negativeValuesAllowed="1" formula="6aa9bf5b-8cf1-445b-b1c5-b7ac97c5c0ef" value="40" displayUnit="pts/min">
                   <Info flag="8" seq="1" ref="0" bb="2" group="98" />
+                  <Origin />
                 </Parameter>
               </Children>
             </OutputInterval>
@@ -349,17 +381,18 @@
         </OutputSelections>
         <FormulaCache>
           <Formulas>
-            <ConstantFormula id="9443e33f-2afb-4cb8-8fb0-399949bad9f5" value="1440" />
-            <ConstantFormula id="7a73986d-a5ed-45bf-9f79-31a14371a6c6" value="0.0666666666666667" />
+            <ConstantFormula id="3ab6d85d-68e5-42d3-be59-8a61e5917615" value="1440" />
+            <ConstantFormula id="6aa9bf5b-8cf1-445b-b1c5-b7ac97c5c0ef" value="0.0666666666666667" />
           </Formulas>
           <StringMap />
         </FormulaCache>
       </SimulationSettings>
       <AllCalculationMethods>
-        <CoreCalculationMethod id="541649d0-0bd5-42ef-a6a5-d279ee9eafc9" name="Cellular partition coefficient method - Berezhkovskiy" icon="CoreCalculationMethod" bbVersion="0" category="DistributionCellular">
+        <CoreCalculationMethod id="3489b338-c061-4b80-a90a-e33eb876a773" name="Cellular partition coefficient method - Berezhkovskiy" icon="CoreCalculationMethod" bbVersion="0" category="DistributionCellular">
+          <Creation createdAt="5248846165144509395" createdBy="Michael" creationMode="New" origin="Other" />
           <OutputFormulas>
             <KeyValue>
-              <Formula id="78afde4e-5918-4603-8f66-50e68f0842a2" name="PARAM_K_rbc" formula="(f_water_rbc + f_lipids_rbc * 10^LogMA + f_proteins_rbc * KProt)*fu">
+              <Formula id="c369287f-2f63-4615-9cd8-deb98fd391e3" name="PARAM_K_rbc" formula="(f_water_rbc + f_lipids_rbc * 10^LogMA + f_proteins_rbc * KProt)*fu">
                 <Paths>
                   <Path path="0" as="1" dim="2" />
                   <Path path="3" as="4" dim="5" />
@@ -378,7 +411,7 @@
               </ParameterDescriptor>
             </KeyValue>
             <KeyValue>
-              <Formula id="54e2f0c5-8f02-44d5-aeea-8e5f81f5e781" name="PARAM_K_cell_pls_Berezhkovskiy" formula="(10^LogP * (V_nlt + 0.3 * V_pht) +  0.7 * V_pht + V_wt / fu_t) / (10^LogP * (V_nlp + 0.3 * V_php) +  0.7 * V_php + V_wp / fu)">
+              <Formula id="1a36038e-92aa-4dbb-9038-b4cd6323e903" name="PARAM_K_cell_pls_Berezhkovskiy" formula="(10^LogP * (V_nlt + 0.3 * V_pht) +  0.7 * V_pht + V_wt / fu_t) / (10^LogP * (V_nlp + 0.3 * V_php) +  0.7 * V_php + V_wp / fu)">
                 <Paths>
                   <Path path="14" as="15" dim="2" />
                   <Path path="0" as="1" dim="2" />
@@ -401,7 +434,7 @@
               </ParameterDescriptor>
             </KeyValue>
             <KeyValue>
-              <Formula id="13b3cee2-0379-4c1a-9e61-aef5091e99a6" name="PARAM_K_cell_pls_fat" formula="(10^LogP_ow * (V_nlt + 0.3 * V_pht) +  0.7 * V_pht + V_wt / fu_t) / (10^LogP_ow * (V_nlp + 0.3 * V_php) +  0.7 * V_php + V_wp / fu)">
+              <Formula id="c20fd607-9d07-44ec-ae5a-2311dc6fb542" name="PARAM_K_cell_pls_fat" formula="(10^LogP_ow * (V_nlt + 0.3 * V_pht) +  0.7 * V_pht + V_wt / fu_t) / (10^LogP_ow * (V_nlp + 0.3 * V_php) +  0.7 * V_php + V_wp / fu)">
                 <Paths>
                   <Path path="14" as="15" dim="2" />
                   <Path path="0" as="1" dim="2" />
@@ -426,8 +459,9 @@
           </OutputFormulas>
           <HelpParameters>
             <KeyValue>
-              <Parameter id="63823ca0-69cc-49ec-bc0a-ef52678b7264" name="logP (oil/water,pKa)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="62e6422c-697a-4ec0-b082-c26154883787">
+              <Parameter id="683b184d-071e-4864-a397-b8aaa3ea5575" name="logP (oil/water,pKa)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="f60aecd0-23ff-4232-bb9b-189051482030">
                 <Info flag="58" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -436,8 +470,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="752911e0-8140-4fb8-a7a1-22cfe2eb92ab" name="logP (veg.oil/water)" icon="Parameter" persistable="0" isFixedValue="0" dim="Log Units" quantityType="Parameter" formula="57f25c43-bc75-4d99-8356-2b2ec725cde7" displayUnit="Log Units">
+              <Parameter id="53e05f6e-0e29-4a97-a54f-94a920c6802c" name="logP (veg.oil/water)" icon="Parameter" persistable="0" isFixedValue="0" dim="Log Units" quantityType="Parameter" negativeValuesAllowed="1" formula="21dc92c8-9404-4fc6-80d6-4fcf0d3354c6" displayUnit="Log Units">
                 <Info flag="58" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -446,8 +481,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="36cfa4b5-f5ef-4b5e-bca8-6560e96d98a3" name="LogPow_pKa_DiproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="d97f9bbc-d793-426c-b3f7-000495aba612">
+              <Parameter id="32e60605-2642-4163-be60-32a1665319d8" name="LogPow_pKa_DiproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="6c9567d7-51ae-4ece-9a39-ecf270a10a60">
                 <Info flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -456,8 +492,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="ab27ebb4-942a-4522-9e2f-d2a6942d4fa7" name="LogPow_pKa_DiproticBase" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="71a560ac-06e5-4e90-98d2-8814c09a453d">
+              <Parameter id="ce015817-9b3d-4a5c-ab0d-83173842aa03" name="LogPow_pKa_DiproticBase" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="155641b1-7e8f-40b4-ae23-2243ff9615b7">
                 <Info flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -466,8 +503,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="6888a68a-caee-451b-8329-1f5987f91123" name="LogPow_pKa_DiproticBaseMonoproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="f4b9214e-30dd-4cad-a03d-a8e0d877ac9e">
+              <Parameter id="0845635b-434b-4d19-b5f4-7753f9d7fe4f" name="LogPow_pKa_DiproticBaseMonoproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="2af22bea-9523-4d2d-929a-17db0725e4b6">
                 <Info flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -476,8 +514,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="4b00fcd8-902a-48a3-8bf1-b8c97f011c20" name="LogPow_pKa_MonoproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="a4635681-a1a8-49bc-8d9c-b468b772eda6">
+              <Parameter id="54aa723b-b096-4f22-bb91-b550bfa22c9f" name="LogPow_pKa_MonoproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="2c32697b-0b93-41de-9dd6-c1d3731981f9">
                 <Info flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -486,8 +525,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="a33e6619-2c3a-456c-a33b-c418334e754c" name="LogPow_pKa_MonoproticBase" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="be06b320-8b2f-4d70-b5fb-2eaef61739b7">
+              <Parameter id="89db5663-e875-4ef2-9af1-e6f6dbf9f83e" name="LogPow_pKa_MonoproticBase" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="25fb3cc1-8c52-4fb1-b91c-de5843d6c0ac">
                 <Info flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -496,8 +536,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="0b6ab677-7de3-41a6-aac6-1fbf716b612f" name="LogPow_pKa_MonoproticBaseDiproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="4121521f-4c5f-4394-97de-be76c7b2ad31">
+              <Parameter id="8621d0d0-2cc8-403f-8658-df582eba4d6d" name="LogPow_pKa_MonoproticBaseDiproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="7d353605-bacd-4db6-b9eb-3f8803c2eb6d">
                 <Info flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -506,8 +547,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="1dd208ee-bc38-43cf-b147-7534bea345b6" name="LogPow_pKa_MonoproticBaseMonoproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="0ff58c51-6d49-43d0-8f3a-e9ef8a8f1136">
+              <Parameter id="63ce5a79-7c71-4e4b-ab42-fcf0aac3a470" name="LogPow_pKa_MonoproticBaseMonoproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="3f0cf68a-4344-44d0-a9f5-7102b135256e">
                 <Info flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -516,8 +558,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="3c4897bf-2c23-4314-8ac9-6bfbd59630ce" name="LogPow_pKa_Neutral" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" value="0">
+              <Parameter id="4793c551-0873-40e7-8e79-5c9c1400595f" name="LogPow_pKa_Neutral" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" value="0">
                 <Info flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -526,8 +569,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="207d1608-e960-4f27-9e91-5f7c915e7bd5" name="LogPow_pKa_TriproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="dd204bad-b7c8-4eef-8307-5e1297d3858c">
+              <Parameter id="74661862-e345-4fa5-9ec9-4f8088a2b7ca" name="LogPow_pKa_TriproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="6c061d65-3bb5-4906-a3ff-6cfdb8c09a09">
                 <Info flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -536,8 +580,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="8dc23bce-00de-4bd4-8ea8-6bfc7e342e3a" name="LogPow_pKa_TriproticBase" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="1edbf9be-9630-4053-86cb-46e027b5ec08">
+              <Parameter id="4388d796-c9fa-42db-bb99-04c94baea6b6" name="LogPow_pKa_TriproticBase" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="066fa443-9729-494a-9af7-51c65c647ba1">
                 <Info flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -546,8 +591,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="dcbf2cb9-5c16-4b97-8ead-7419c92a3a35" name="Fraction unbound (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" formula="45e39495-5810-470d-92a1-be49f2c81dbf">
+              <Parameter id="e5a01404-3355-4bdd-844d-2453f39b56d1" name="Fraction unbound (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="50af33e3-b02e-4e58-b6d8-c42119466184">
                 <Info flag="58" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -558,7 +604,7 @@
           </HelpParameters>
           <FormulaCache>
             <Formulas>
-              <Formula id="62e6422c-697a-4ec0-b082-c26154883787" name="PARAM_LogP_ow_pKa" formula="LogPow_pKa_Neutral + LogPow_pKa_MonoproticBase + LogPow_pKa_MonoproticAcid + LogPow_pKa_DiproticBase + LogPow_pKa_DiproticAcid + LogPow_pKa_MonoproticBaseMonoproticAcid + LogPow_pKa_TriproticAcid + LogPow_pKa_TriproticBase + LogPow_pKa_DiproticBaseMonoproticAcid + LogPow_pKa_MonoproticBaseDiproticAcid">
+              <Formula id="f60aecd0-23ff-4232-bb9b-189051482030" name="PARAM_LogP_ow_pKa" formula="LogPow_pKa_Neutral + LogPow_pKa_MonoproticBase + LogPow_pKa_MonoproticAcid + LogPow_pKa_DiproticBase + LogPow_pKa_DiproticAcid + LogPow_pKa_MonoproticBaseMonoproticAcid + LogPow_pKa_TriproticAcid + LogPow_pKa_TriproticBase + LogPow_pKa_DiproticBaseMonoproticAcid + LogPow_pKa_MonoproticBaseDiproticAcid">
                 <Paths>
                   <Path path="31" as="32" />
                   <Path path="33" as="34" />
@@ -572,13 +618,13 @@
                   <Path path="49" as="50" />
                 </Paths>
               </Formula>
-              <Formula id="57f25c43-bc75-4d99-8356-2b2ec725cde7" name="PARAM_LogP_ow" dim="Log Units" formula="1.115 * LogP - 1.35 - LogP_ow_pKa">
+              <Formula id="21dc92c8-9404-4fc6-80d6-4fcf0d3354c6" name="PARAM_LogP_ow" dim="Log Units" formula="1.115 * LogP - 1.35 - LogP_ow_pKa">
                 <Paths>
                   <Path path="3" as="16" dim="5" />
                   <Path path="51" as="52" />
                 </Paths>
               </Formula>
-              <Formula id="d97f9bbc-d793-426c-b3f7-000495aba612" name="PARAM_LogPow_pKa_DiproticAcid" formula="IsDiproticAcid ? Log10(1+10^(2*pH_PLS-pKa_Acid_0-pKa_Acid_1)) : 0">
+              <Formula id="6c9567d7-51ae-4ece-9a39-ecf270a10a60" name="PARAM_LogPow_pKa_DiproticAcid" formula="IsDiproticAcid ? Log10(1+10^(2*pH_PLS-pKa_Acid_0-pKa_Acid_1)) : 0">
                 <Paths>
                   <Path path="53" as="54" />
                   <Path path="55" as="56" />
@@ -586,7 +632,7 @@
                   <Path path="59" as="60" />
                 </Paths>
               </Formula>
-              <Formula id="71a560ac-06e5-4e90-98d2-8814c09a453d" name="PARAM_LogPow_pKa_DiproticBase" formula="IsDiproticBase ? Log10(1+10^(pKa_Base_0+pKa_Base_1-2*pH_PLS)) : 0">
+              <Formula id="155641b1-7e8f-40b4-ae23-2243ff9615b7" name="PARAM_LogPow_pKa_DiproticBase" formula="IsDiproticBase ? Log10(1+10^(pKa_Base_0+pKa_Base_1-2*pH_PLS)) : 0">
                 <Paths>
                   <Path path="61" as="62" />
                   <Path path="63" as="64" />
@@ -594,7 +640,7 @@
                   <Path path="59" as="60" />
                 </Paths>
               </Formula>
-              <Formula id="f4b9214e-30dd-4cad-a03d-a8e0d877ac9e" name="PARAM_LogPow_pKa_DiproticBaseMonoproticAcid" formula="IsDiproticBaseMonoproticAcid ? Log10(1+10^(pKa_Base_0+pKa_Base_1-pKa_Acid_0-pH_PLS)) : 0">
+              <Formula id="2af22bea-9523-4d2d-929a-17db0725e4b6" name="PARAM_LogPow_pKa_DiproticBaseMonoproticAcid" formula="IsDiproticBaseMonoproticAcid ? Log10(1+10^(pKa_Base_0+pKa_Base_1-pKa_Acid_0-pH_PLS)) : 0">
                 <Paths>
                   <Path path="67" as="68" />
                   <Path path="55" as="56" />
@@ -603,21 +649,21 @@
                   <Path path="59" as="60" />
                 </Paths>
               </Formula>
-              <Formula id="a4635681-a1a8-49bc-8d9c-b468b772eda6" name="PARAM_LogPow_pKa_MonoproticAcid" formula="IsMonoproticAcid ? Log10(1+10^(pH_PLS-pKa_Acid_0)) : 0">
+              <Formula id="2c32697b-0b93-41de-9dd6-c1d3731981f9" name="PARAM_LogPow_pKa_MonoproticAcid" formula="IsMonoproticAcid ? Log10(1+10^(pH_PLS-pKa_Acid_0)) : 0">
                 <Paths>
                   <Path path="69" as="70" />
                   <Path path="55" as="56" />
                   <Path path="59" as="60" />
                 </Paths>
               </Formula>
-              <Formula id="be06b320-8b2f-4d70-b5fb-2eaef61739b7" name="PARAM_LogPow_pKa_MonoproticBase" formula="IsMonoproticBase ? Log10(1+10^(pKa_Base_0-pH_PLS)) : 0">
+              <Formula id="25fb3cc1-8c52-4fb1-b91c-de5843d6c0ac" name="PARAM_LogPow_pKa_MonoproticBase" formula="IsMonoproticBase ? Log10(1+10^(pKa_Base_0-pH_PLS)) : 0">
                 <Paths>
                   <Path path="71" as="72" />
                   <Path path="63" as="64" />
                   <Path path="59" as="60" />
                 </Paths>
               </Formula>
-              <Formula id="4121521f-4c5f-4394-97de-be76c7b2ad31" name="PARAM_LogPow_pKa_MonoproticBaseDiproticAcid" formula="IsMonoproticBaseDiproticAcid ? Log10(1+10^(pH_PLS-pKa_Acid_0-pKa_Acid_1+pKa_Base_0)) : 0">
+              <Formula id="7d353605-bacd-4db6-b9eb-3f8803c2eb6d" name="PARAM_LogPow_pKa_MonoproticBaseDiproticAcid" formula="IsMonoproticBaseDiproticAcid ? Log10(1+10^(pH_PLS-pKa_Acid_0-pKa_Acid_1+pKa_Base_0)) : 0">
                 <Paths>
                   <Path path="73" as="74" />
                   <Path path="55" as="56" />
@@ -626,7 +672,7 @@
                   <Path path="59" as="60" />
                 </Paths>
               </Formula>
-              <Formula id="0ff58c51-6d49-43d0-8f3a-e9ef8a8f1136" name="PARAM_LogPow_pKa_MonoproticBaseMonoproticAcid" formula="IsMonoproticBaseMonoproticAcid ? Log10(1+10^(pKa_Base_0-pKa_Acid_0)) : 0">
+              <Formula id="3f0cf68a-4344-44d0-a9f5-7102b135256e" name="PARAM_LogPow_pKa_MonoproticBaseMonoproticAcid" formula="IsMonoproticBaseMonoproticAcid ? Log10(1+10^(pKa_Base_0-pKa_Acid_0)) : 0">
                 <Paths>
                   <Path path="75" as="76" />
                   <Path path="55" as="56" />
@@ -634,7 +680,7 @@
                   <Path path="59" as="60" />
                 </Paths>
               </Formula>
-              <Formula id="dd204bad-b7c8-4eef-8307-5e1297d3858c" name="PARAM_LogPow_pKa_TriproticAcid" formula="IsTriproticAcid ? Log10(1+10^(3*pH_PLS-pKa_Acid_0-pKa_Acid_1-pKa_Acid_2)) : 0">
+              <Formula id="6c061d65-3bb5-4906-a3ff-6cfdb8c09a09" name="PARAM_LogPow_pKa_TriproticAcid" formula="IsTriproticAcid ? Log10(1+10^(3*pH_PLS-pKa_Acid_0-pKa_Acid_1-pKa_Acid_2)) : 0">
                 <Paths>
                   <Path path="77" as="78" />
                   <Path path="55" as="56" />
@@ -643,7 +689,7 @@
                   <Path path="59" as="60" />
                 </Paths>
               </Formula>
-              <Formula id="1edbf9be-9630-4053-86cb-46e027b5ec08" name="PARAM_LogPow_pKa_TriproticBase" formula="IsTriproticBase ? Log10(1+10^(pKa_Base_0+pKa_Base_1+pKa_Base_2-3*pH_PLS)) : 0">
+              <Formula id="066fa443-9729-494a-9af7-51c65c647ba1" name="PARAM_LogPow_pKa_TriproticBase" formula="IsTriproticBase ? Log10(1+10^(pKa_Base_0+pKa_Base_1+pKa_Base_2-3*pH_PLS)) : 0">
                 <Paths>
                   <Path path="81" as="82" />
                   <Path path="63" as="64" />
@@ -652,7 +698,7 @@
                   <Path path="59" as="60" />
                 </Paths>
               </Formula>
-              <Formula id="45e39495-5810-470d-92a1-be49f2c81dbf" name="PARAM_fu_tissue_Berezhkovskiy" dim="Fraction" formula="1 / (1 + (1 - fu)/fu * RA)">
+              <Formula id="50af33e3-b02e-4e58-b6d8-c42119466184" name="PARAM_fu_tissue_Berezhkovskiy" dim="Fraction" formula="1 / (1 + (1 - fu)/fu * RA)">
                 <Paths>
                   <Path path="0" as="1" dim="2" />
                   <Path path="85" as="86" />
@@ -750,10 +796,11 @@
             </StringMap>
           </FormulaCache>
         </CoreCalculationMethod>
-        <CoreCalculationMethod id="2c77d7a4-8b4b-41bd-8fc9-a9d867825b17" name="Cellular partition coefficient method - PK-Sim Standard" icon="CoreCalculationMethod" bbVersion="0" category="DistributionCellular">
+        <CoreCalculationMethod id="b9a77313-1d92-470b-85ea-7c5523d644e8" name="Cellular partition coefficient method - PK-Sim Standard" icon="CoreCalculationMethod" bbVersion="0" category="DistributionCellular">
+          <Creation createdAt="5248846165144529346" createdBy="Michael" creationMode="New" origin="Other" />
           <OutputFormulas>
             <KeyValue>
-              <Formula id="7ae53563-5301-40b3-b6a6-53dd11e1fc45" name="PARAM_K_rbc" formula="(f_water_rbc + f_lipids_rbc * 10^LogMA + f_proteins_rbc * KProt)*fu">
+              <Formula id="1b26871f-b67c-4a47-9d9f-90442bf98dfa" name="PARAM_K_rbc" formula="(f_water_rbc + f_lipids_rbc * 10^LogMA + f_proteins_rbc * KProt)*fu">
                 <Paths>
                   <Path path="0" as="1" dim="2" />
                   <Path path="3" as="4" dim="5" />
@@ -772,7 +819,7 @@
               </ParameterDescriptor>
             </KeyValue>
             <KeyValue>
-              <Formula id="c3101a6f-a58b-4f9a-aa57-f1b70508bf9d" name="PARAM_K_cell_pls_PK-Sim_Standard" formula="(f_water + f_lipids * 10^LogMA + f_proteins * KProt) * fu">
+              <Formula id="b75f1014-d714-400d-8ffa-0e6b1295a408" name="PARAM_K_cell_pls_PK-Sim_Standard" formula="(f_water + f_lipids * 10^LogMA + f_proteins * KProt) * fu">
                 <Paths>
                   <Path path="0" as="1" dim="2" />
                   <Path path="3" as="4" dim="5" />
@@ -817,10 +864,11 @@
             </StringMap>
           </FormulaCache>
         </CoreCalculationMethod>
-        <CoreCalculationMethod id="140d7875-6736-4361-b474-2deb61f62108" name="Cellular partition coefficient method - Poulin and Theil" icon="CoreCalculationMethod" bbVersion="0" category="DistributionCellular">
+        <CoreCalculationMethod id="4963c970-1237-4f3c-a9d6-141b9560d37b" name="Cellular partition coefficient method - Poulin and Theil" icon="CoreCalculationMethod" bbVersion="0" category="DistributionCellular">
+          <Creation createdAt="5248846165144529346" createdBy="Michael" creationMode="New" origin="Other" />
           <OutputFormulas>
             <KeyValue>
-              <Formula id="b63a6541-2fbc-44fa-8a35-c753cc99629a" name="PARAM_K_rbc" formula="(f_water_rbc + f_lipids_rbc * 10^LogMA + f_proteins_rbc * KProt)*fu">
+              <Formula id="77dea0bf-9299-4beb-b127-2189d124a986" name="PARAM_K_rbc" formula="(f_water_rbc + f_lipids_rbc * 10^LogMA + f_proteins_rbc * KProt)*fu">
                 <Paths>
                   <Path path="0" as="1" dim="2" />
                   <Path path="3" as="4" dim="5" />
@@ -839,7 +887,7 @@
               </ParameterDescriptor>
             </KeyValue>
             <KeyValue>
-              <Formula id="5733b974-8170-4fba-b5f9-edbe66cc9d9e" name="PARAM_K_cell_pls_Poulin_and_Theil" formula="(10^LogP * (V_nlt + 0.3 * V_pht) +  0.7 * V_pht + V_wt) / (10^LogP * (V_nlp + 0.3 * V_php) +  0.7 * V_php + V_wp) * (fu / fu_t)  ">
+              <Formula id="ded45e53-6452-48c0-90ba-744dd9b6f92d" name="PARAM_K_cell_pls_Poulin_and_Theil" formula="(10^LogP * (V_nlt + 0.3 * V_pht) +  0.7 * V_pht + V_wt) / (10^LogP * (V_nlp + 0.3 * V_php) +  0.7 * V_php + V_wp) * (fu / fu_t)  ">
                 <Paths>
                   <Path path="14" as="15" dim="2" />
                   <Path path="0" as="1" dim="2" />
@@ -862,7 +910,7 @@
               </ParameterDescriptor>
             </KeyValue>
             <KeyValue>
-              <Formula id="ad208c96-5f72-4694-8f8f-292cd7fa03aa" name="PARAM_K_cell_pls_fat" formula="(10^LogP_ow * (V_nlt + 0.3 * V_pht) +  0.7 * V_pht + V_wt) / (10^LogP_ow * (V_nlp + 0.3 * V_php) +  0.7 * V_php + V_wp) * (fu / fu_t)">
+              <Formula id="1376f0ed-808f-4921-b560-e3731a4e9283" name="PARAM_K_cell_pls_fat" formula="(10^LogP_ow * (V_nlt + 0.3 * V_pht) +  0.7 * V_pht + V_wt) / (10^LogP_ow * (V_nlp + 0.3 * V_php) +  0.7 * V_php + V_wp) * (fu / fu_t)">
                 <Paths>
                   <Path path="14" as="15" dim="2" />
                   <Path path="0" as="1" dim="2" />
@@ -887,8 +935,9 @@
           </OutputFormulas>
           <HelpParameters>
             <KeyValue>
-              <Parameter id="4b36bf43-7e0e-4074-809d-dea86cef7e5d" name="logP (oil/water,pKa)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="65feda52-c5d3-4389-bd7a-db851eab47ed">
+              <Parameter id="402e8d64-a1ad-4cd3-a72f-f0c3b5a582b9" name="logP (oil/water,pKa)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="5716e37a-326e-467d-945f-24528e40d2dc">
                 <Info flag="58" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -897,8 +946,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="ed54d894-d39e-4bc6-9810-beeb3b2203d5" name="logP (veg.oil/water)" icon="Parameter" persistable="0" isFixedValue="0" dim="Log Units" quantityType="Parameter" formula="9fcd9036-17ca-4227-8773-72ed0048e07c" displayUnit="Log Units">
+              <Parameter id="0b7caaf6-af7a-4289-a8ee-8fd250ae3d6b" name="logP (veg.oil/water)" icon="Parameter" persistable="0" isFixedValue="0" dim="Log Units" quantityType="Parameter" negativeValuesAllowed="1" formula="25bcab44-b553-4acd-84dc-b899ec84d6a9" displayUnit="Log Units">
                 <Info flag="58" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -907,8 +957,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="3876492b-b6d1-4b8e-a704-179d8e25cf13" name="LogPow_pKa_DiproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="7b0ab8c7-cb97-4611-923d-08be9c364cca">
+              <Parameter id="857c88d0-5958-4f24-8741-05aac613509b" name="LogPow_pKa_DiproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="955de0ac-2c31-4d77-b354-ae2acdaa4620">
                 <Info flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -917,8 +968,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="42499580-2928-49ec-b82a-51f6f24ef639" name="LogPow_pKa_DiproticBase" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="ce8f02b7-0406-41e7-a879-d48cf2f60adb">
+              <Parameter id="fdbba9d2-c456-49f7-9419-daa7896dfe52" name="LogPow_pKa_DiproticBase" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="34cdabc6-192d-4f65-a3b4-3def73ac29c9">
                 <Info flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -927,8 +979,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="829b4328-01d2-4c4f-82b6-e302cdf0f437" name="LogPow_pKa_DiproticBaseMonoproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="268757a6-a3e8-47e6-8dc4-455a3ae4a8a5">
+              <Parameter id="2682e17e-9e21-44eb-97d9-4166c1e64a23" name="LogPow_pKa_DiproticBaseMonoproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="1b577f23-5cfe-40cf-8b4f-095ace1235bb">
                 <Info flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -937,8 +990,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="00987f40-4d57-4dd6-a316-08ce029af09c" name="LogPow_pKa_MonoproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="7a8d71fc-edf7-4b1d-9493-82e6bf9310f1">
+              <Parameter id="88c1ccd7-6ce2-46af-80de-0cf826ff3c1e" name="LogPow_pKa_MonoproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="cc08369e-a6ec-4bbf-a084-e32920377076">
                 <Info flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -947,8 +1001,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="442a389f-8b86-46f8-815b-7869bffaa6cf" name="LogPow_pKa_MonoproticBase" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="d9e75198-766f-4e5f-bc79-b3f7e589627c">
+              <Parameter id="efc4de42-41ac-4670-a316-f771f3452078" name="LogPow_pKa_MonoproticBase" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="7485d96c-58f4-4253-86be-04ab1a55ab31">
                 <Info flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -957,8 +1012,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="b0c3fe4f-528c-4397-8889-5e2d2c0eac71" name="LogPow_pKa_MonoproticBaseDiproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="36d8b3cd-1cf4-42dc-b608-2225536d0a59">
+              <Parameter id="ad367799-99d5-4793-8971-266c6728c686" name="LogPow_pKa_MonoproticBaseDiproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="b63a5fbc-8724-4730-9448-423e26d6544c">
                 <Info flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -967,8 +1023,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="c6384b6c-742a-42b1-bdbb-f5c72860a816" name="LogPow_pKa_MonoproticBaseMonoproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="70692f9e-a2a6-4daa-aba2-506bab2fb673">
+              <Parameter id="5dff0901-d0ef-4981-9d78-e375769f4ae7" name="LogPow_pKa_MonoproticBaseMonoproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="bad5ee59-2d09-4d4a-a956-e6cad39c99ef">
                 <Info flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -977,8 +1034,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="75dea756-522b-409b-b94f-3c8a11521bd2" name="LogPow_pKa_Neutral" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" value="0">
+              <Parameter id="3a5ec52f-ca07-430c-963f-46d5b30da7c5" name="LogPow_pKa_Neutral" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" value="0">
                 <Info flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -987,8 +1045,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="d4fb8c92-58cb-4d70-bee5-570c1b03c462" name="LogPow_pKa_TriproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="38d745a1-54cd-4f56-a7e1-8138701dd916">
+              <Parameter id="6ba31fe4-a4e4-4630-9f83-6a54f3286ef2" name="LogPow_pKa_TriproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="bc71462c-0263-4699-b63e-a50718035d20">
                 <Info flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -997,8 +1056,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="f4e5d3de-480b-40c2-9511-857949854c75" name="LogPow_pKa_TriproticBase" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="adc8269f-7d66-44b9-940a-80f8a90ef80e">
+              <Parameter id="38a8f7dc-207f-468e-b6d2-3b0a8cd4c99e" name="LogPow_pKa_TriproticBase" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="a1fd935f-2059-4bba-845b-19a1cfd375d0">
                 <Info flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -1007,8 +1067,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="bba97ef5-ca0c-488c-b71b-ca84336db1b6" name="Fraction unbound (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" formula="13f9a9e5-4a6f-44fb-a68f-4e65fdc50824">
+              <Parameter id="bf9e42c7-cb82-47ed-a93d-dd19eaa152c2" name="Fraction unbound (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="1c8886f2-f980-4270-b8b8-8d6434993a02">
                 <Info flag="58" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -1019,7 +1080,7 @@
           </HelpParameters>
           <FormulaCache>
             <Formulas>
-              <Formula id="65feda52-c5d3-4389-bd7a-db851eab47ed" name="PARAM_LogP_ow_pKa" formula="LogPow_pKa_Neutral + LogPow_pKa_MonoproticBase + LogPow_pKa_MonoproticAcid + LogPow_pKa_DiproticBase + LogPow_pKa_DiproticAcid + LogPow_pKa_MonoproticBaseMonoproticAcid + LogPow_pKa_TriproticAcid + LogPow_pKa_TriproticBase + LogPow_pKa_DiproticBaseMonoproticAcid + LogPow_pKa_MonoproticBaseDiproticAcid">
+              <Formula id="5716e37a-326e-467d-945f-24528e40d2dc" name="PARAM_LogP_ow_pKa" formula="LogPow_pKa_Neutral + LogPow_pKa_MonoproticBase + LogPow_pKa_MonoproticAcid + LogPow_pKa_DiproticBase + LogPow_pKa_DiproticAcid + LogPow_pKa_MonoproticBaseMonoproticAcid + LogPow_pKa_TriproticAcid + LogPow_pKa_TriproticBase + LogPow_pKa_DiproticBaseMonoproticAcid + LogPow_pKa_MonoproticBaseDiproticAcid">
                 <Paths>
                   <Path path="31" as="32" />
                   <Path path="33" as="34" />
@@ -1033,13 +1094,13 @@
                   <Path path="49" as="50" />
                 </Paths>
               </Formula>
-              <Formula id="9fcd9036-17ca-4227-8773-72ed0048e07c" name="PARAM_LogP_ow" dim="Log Units" formula="1.115 * LogP - 1.35 - LogP_ow_pKa">
+              <Formula id="25bcab44-b553-4acd-84dc-b899ec84d6a9" name="PARAM_LogP_ow" dim="Log Units" formula="1.115 * LogP - 1.35 - LogP_ow_pKa">
                 <Paths>
                   <Path path="3" as="16" dim="5" />
                   <Path path="51" as="52" />
                 </Paths>
               </Formula>
-              <Formula id="7b0ab8c7-cb97-4611-923d-08be9c364cca" name="PARAM_LogPow_pKa_DiproticAcid" formula="IsDiproticAcid ? Log10(1+10^(2*pH_PLS-pKa_Acid_0-pKa_Acid_1)) : 0">
+              <Formula id="955de0ac-2c31-4d77-b354-ae2acdaa4620" name="PARAM_LogPow_pKa_DiproticAcid" formula="IsDiproticAcid ? Log10(1+10^(2*pH_PLS-pKa_Acid_0-pKa_Acid_1)) : 0">
                 <Paths>
                   <Path path="53" as="54" />
                   <Path path="55" as="56" />
@@ -1047,7 +1108,7 @@
                   <Path path="59" as="60" />
                 </Paths>
               </Formula>
-              <Formula id="ce8f02b7-0406-41e7-a879-d48cf2f60adb" name="PARAM_LogPow_pKa_DiproticBase" formula="IsDiproticBase ? Log10(1+10^(pKa_Base_0+pKa_Base_1-2*pH_PLS)) : 0">
+              <Formula id="34cdabc6-192d-4f65-a3b4-3def73ac29c9" name="PARAM_LogPow_pKa_DiproticBase" formula="IsDiproticBase ? Log10(1+10^(pKa_Base_0+pKa_Base_1-2*pH_PLS)) : 0">
                 <Paths>
                   <Path path="61" as="62" />
                   <Path path="63" as="64" />
@@ -1055,7 +1116,7 @@
                   <Path path="59" as="60" />
                 </Paths>
               </Formula>
-              <Formula id="268757a6-a3e8-47e6-8dc4-455a3ae4a8a5" name="PARAM_LogPow_pKa_DiproticBaseMonoproticAcid" formula="IsDiproticBaseMonoproticAcid ? Log10(1+10^(pKa_Base_0+pKa_Base_1-pKa_Acid_0-pH_PLS)) : 0">
+              <Formula id="1b577f23-5cfe-40cf-8b4f-095ace1235bb" name="PARAM_LogPow_pKa_DiproticBaseMonoproticAcid" formula="IsDiproticBaseMonoproticAcid ? Log10(1+10^(pKa_Base_0+pKa_Base_1-pKa_Acid_0-pH_PLS)) : 0">
                 <Paths>
                   <Path path="67" as="68" />
                   <Path path="55" as="56" />
@@ -1064,21 +1125,21 @@
                   <Path path="59" as="60" />
                 </Paths>
               </Formula>
-              <Formula id="7a8d71fc-edf7-4b1d-9493-82e6bf9310f1" name="PARAM_LogPow_pKa_MonoproticAcid" formula="IsMonoproticAcid ? Log10(1+10^(pH_PLS-pKa_Acid_0)) : 0">
+              <Formula id="cc08369e-a6ec-4bbf-a084-e32920377076" name="PARAM_LogPow_pKa_MonoproticAcid" formula="IsMonoproticAcid ? Log10(1+10^(pH_PLS-pKa_Acid_0)) : 0">
                 <Paths>
                   <Path path="69" as="70" />
                   <Path path="55" as="56" />
                   <Path path="59" as="60" />
                 </Paths>
               </Formula>
-              <Formula id="d9e75198-766f-4e5f-bc79-b3f7e589627c" name="PARAM_LogPow_pKa_MonoproticBase" formula="IsMonoproticBase ? Log10(1+10^(pKa_Base_0-pH_PLS)) : 0">
+              <Formula id="7485d96c-58f4-4253-86be-04ab1a55ab31" name="PARAM_LogPow_pKa_MonoproticBase" formula="IsMonoproticBase ? Log10(1+10^(pKa_Base_0-pH_PLS)) : 0">
                 <Paths>
                   <Path path="71" as="72" />
                   <Path path="63" as="64" />
                   <Path path="59" as="60" />
                 </Paths>
               </Formula>
-              <Formula id="36d8b3cd-1cf4-42dc-b608-2225536d0a59" name="PARAM_LogPow_pKa_MonoproticBaseDiproticAcid" formula="IsMonoproticBaseDiproticAcid ? Log10(1+10^(pH_PLS-pKa_Acid_0-pKa_Acid_1+pKa_Base_0)) : 0">
+              <Formula id="b63a5fbc-8724-4730-9448-423e26d6544c" name="PARAM_LogPow_pKa_MonoproticBaseDiproticAcid" formula="IsMonoproticBaseDiproticAcid ? Log10(1+10^(pH_PLS-pKa_Acid_0-pKa_Acid_1+pKa_Base_0)) : 0">
                 <Paths>
                   <Path path="73" as="74" />
                   <Path path="55" as="56" />
@@ -1087,7 +1148,7 @@
                   <Path path="59" as="60" />
                 </Paths>
               </Formula>
-              <Formula id="70692f9e-a2a6-4daa-aba2-506bab2fb673" name="PARAM_LogPow_pKa_MonoproticBaseMonoproticAcid" formula="IsMonoproticBaseMonoproticAcid ? Log10(1+10^(pKa_Base_0-pKa_Acid_0)) : 0">
+              <Formula id="bad5ee59-2d09-4d4a-a956-e6cad39c99ef" name="PARAM_LogPow_pKa_MonoproticBaseMonoproticAcid" formula="IsMonoproticBaseMonoproticAcid ? Log10(1+10^(pKa_Base_0-pKa_Acid_0)) : 0">
                 <Paths>
                   <Path path="75" as="76" />
                   <Path path="55" as="56" />
@@ -1095,7 +1156,7 @@
                   <Path path="59" as="60" />
                 </Paths>
               </Formula>
-              <Formula id="38d745a1-54cd-4f56-a7e1-8138701dd916" name="PARAM_LogPow_pKa_TriproticAcid" formula="IsTriproticAcid ? Log10(1+10^(3*pH_PLS-pKa_Acid_0-pKa_Acid_1-pKa_Acid_2)) : 0">
+              <Formula id="bc71462c-0263-4699-b63e-a50718035d20" name="PARAM_LogPow_pKa_TriproticAcid" formula="IsTriproticAcid ? Log10(1+10^(3*pH_PLS-pKa_Acid_0-pKa_Acid_1-pKa_Acid_2)) : 0">
                 <Paths>
                   <Path path="77" as="78" />
                   <Path path="55" as="56" />
@@ -1104,7 +1165,7 @@
                   <Path path="59" as="60" />
                 </Paths>
               </Formula>
-              <Formula id="adc8269f-7d66-44b9-940a-80f8a90ef80e" name="PARAM_LogPow_pKa_TriproticBase" formula="IsTriproticBase ? Log10(1+10^(pKa_Base_0+pKa_Base_1+pKa_Base_2-3*pH_PLS)) : 0">
+              <Formula id="a1fd935f-2059-4bba-845b-19a1cfd375d0" name="PARAM_LogPow_pKa_TriproticBase" formula="IsTriproticBase ? Log10(1+10^(pKa_Base_0+pKa_Base_1+pKa_Base_2-3*pH_PLS)) : 0">
                 <Paths>
                   <Path path="81" as="82" />
                   <Path path="63" as="64" />
@@ -1113,7 +1174,7 @@
                   <Path path="59" as="60" />
                 </Paths>
               </Formula>
-              <Formula id="13f9a9e5-4a6f-44fb-a68f-4e65fdc50824" name="PARAM_fu_tissue_Poulin_and_Theil" dim="Fraction" formula="1 / (1 + (1 - fu)/fu * RA)">
+              <Formula id="1c8886f2-f980-4270-b8b8-8d6434993a02" name="PARAM_fu_tissue_Poulin_and_Theil" dim="Fraction" formula="1 / (1 + (1 - fu)/fu * RA)">
                 <Paths>
                   <Path path="0" as="1" dim="2" />
                   <Path path="85" as="86" />
@@ -1211,10 +1272,11 @@
             </StringMap>
           </FormulaCache>
         </CoreCalculationMethod>
-        <CoreCalculationMethod id="ca6d6e15-4fdc-47f0-b860-1ca64ba38667" name="Cellular partition coefficient method - Rodgers and Rowland" icon="CoreCalculationMethod" bbVersion="0" category="DistributionCellular">
+        <CoreCalculationMethod id="f688a277-ecf9-44fb-af85-229ed7c7cf55" name="Cellular partition coefficient method - Rodgers and Rowland" icon="CoreCalculationMethod" bbVersion="0" category="DistributionCellular">
+          <Creation createdAt="5248846165144549325" createdBy="Michael" creationMode="New" origin="Other" />
           <OutputFormulas>
             <KeyValue>
-              <Formula id="7c3cf631-2743-46ae-ba3f-815e2505f0ad" name="PARAM_K_rbc" formula="K_pu_bc*fu">
+              <Formula id="b2fd94e0-5f4a-413d-ae8c-71116b193613" name="PARAM_K_rbc" formula="K_pu_bc*fu">
                 <Paths>
                   <Path path="0" as="1" dim="2" />
                   <Path path="3" as="4" />
@@ -1229,7 +1291,7 @@
               </ParameterDescriptor>
             </KeyValue>
             <KeyValue>
-              <Formula id="8add22d7-07aa-4c94-8bc9-83485b17a384" name="PARAM_K_cell_pls_Rodgers_and_Rowland" formula="((1+X)/(1+Y)*f_iw + f_ew + (10^LogP*f_nl+(0.3*10^LogP+0.7)*f_np)/(1+Y) + (HasStrongBase ? Ka_AP*AP_T*X/(1+Y) : Ka_PR*(IsNeutral ? PR_T2PR_P_Lipoprotein : PR_T2PR_P_Albumin)))*fu">
+              <Formula id="1d6dcf4a-2f6c-4fbe-b177-f8f02042db30" name="PARAM_K_cell_pls_Rodgers_and_Rowland" formula="((1+X)/(1+Y)*f_iw + f_ew + (10^LogP*f_nl+(0.3*10^LogP+0.7)*f_np)/(1+Y) + (HasStrongBase ? Ka_AP*AP_T*X/(1+Y) : Ka_PR*(IsNeutral ? PR_T2PR_P_Lipoprotein : PR_T2PR_P_Albumin)))*fu">
                 <Paths>
                   <Path path="0" as="1" dim="2" />
                   <Path path="5" as="6" />
@@ -1258,7 +1320,7 @@
               </ParameterDescriptor>
             </KeyValue>
             <KeyValue>
-              <Formula id="bf31a2dd-009d-4e90-84fd-fe91fddc94a7" name="PARAM_K_cell_pls_fat" formula="((1+X)/(1+Y)*f_iw + f_ew + (10^LogP_ow*f_nl+(0.3*10^LogP_ow+0.7)*f_np)/(1+Y) + (HasStrongBase ? Ka_AP*AP_T*X/(1+Y) : Ka_PR*(IsNeutral ? PR_T2PR_P_Lipoprotein : PR_T2PR_P_Albumin)))*fu">
+              <Formula id="72fb9011-5a99-4080-a9cf-8bb5251aa19b" name="PARAM_K_cell_pls_fat" formula="((1+X)/(1+Y)*f_iw + f_ew + (10^LogP_ow*f_nl+(0.3*10^LogP_ow+0.7)*f_np)/(1+Y) + (HasStrongBase ? Ka_AP*AP_T*X/(1+Y) : Ka_PR*(IsNeutral ? PR_T2PR_P_Lipoprotein : PR_T2PR_P_Albumin)))*fu">
                 <Paths>
                   <Path path="0" as="1" dim="2" />
                   <Path path="5" as="6" />
@@ -1289,8 +1351,9 @@
           </OutputFormulas>
           <HelpParameters>
             <KeyValue>
-              <Parameter id="08a5121f-f30c-490c-aad0-4144146c86d3" name="Ka (acidic phospholipids)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="280539b5-bc8b-49ba-8045-01e2890e626c">
+              <Parameter id="70926c43-99ee-4b90-a826-c9192cb1ca2a" name="Ka (acidic phospholipids)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="1b2dd07b-0be8-446b-a483-47521082ab2d">
                 <Info flag="58" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -1299,8 +1362,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="45831be4-cbed-40d8-9ce8-7a7be98c8e8e" name="Ka (proteins)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="873c8d7d-bded-49f8-bcce-3f5ee44a346f">
+              <Parameter id="72e10504-8633-4d4e-83f8-0b6cbdca5439" name="Ka (proteins)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="c4bff630-d5d7-4af8-a13e-a1141bcfb956">
                 <Info flag="58" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -1309,8 +1373,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="74e1c935-9945-4122-baf9-cbb92c885355" name="logP (veg.oil/water)" icon="Parameter" persistable="0" isFixedValue="0" dim="Log Units" quantityType="Parameter" formula="d4bf723e-6f32-40d2-8685-46ed58fd3c6e" displayUnit="Log Units">
+              <Parameter id="f7a5a42b-2c3a-4689-99e5-2691c419a5ed" name="logP (veg.oil/water)" icon="Parameter" persistable="0" isFixedValue="0" dim="Log Units" quantityType="Parameter" negativeValuesAllowed="1" formula="61306e17-a13a-40fd-ba93-2036873be0ac" displayUnit="Log Units">
                 <Info flag="58" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -1319,8 +1384,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="0dd981fa-15eb-42fe-994d-cea2672befc7" name="Partition coefficient (blood cells/plasma unbound)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="6765a8f0-0182-43bd-aeb2-33db9bac005e">
+              <Parameter id="306153f0-ce94-413a-9c18-f611d7e9d40a" name="Partition coefficient (blood cells/plasma unbound)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="88cd0c4d-c77e-4c1e-93a6-cf8e0ec0860a">
                 <Info flag="58" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -1329,8 +1395,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="c96be21b-103b-45c2-a0bc-5ac18242660b" name="X" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="402a0f0c-cb4a-434c-8773-0af8eb4fc420">
+              <Parameter id="2977d186-2665-42a9-a8f4-d7d8d4f3491d" name="X" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="41de144b-c62e-4e50-a46a-cbffa2f6b942">
                 <Info flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -1339,8 +1406,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="616cf769-3b35-4402-8431-023dbdb7d31d" name="X_DiproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="ee95bbfd-47a5-41c5-9886-6ee3831d2ecc">
+              <Parameter id="6b7a1afa-175f-41fd-8ecd-44031b947180" name="X_DiproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="0a88b366-360f-47eb-a6ff-218e4e5f7c65">
                 <Info flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -1349,8 +1417,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="9b34717b-e97f-4f70-9211-2a9f1d4e8ec9" name="X_DiproticBase" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="9f217174-95f9-40db-86ab-05a6e7ee2a8d">
+              <Parameter id="414a156a-6d95-47b1-875b-943851c15546" name="X_DiproticBase" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="f1a955e6-d411-4950-acda-50c036a88d74">
                 <Info flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -1359,8 +1428,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="91f76297-7bf7-4363-b71f-284fd3907ac2" name="X_DiproticBaseMonoproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="b5270c9e-5f71-4b8f-937c-264b13bd3760">
+              <Parameter id="04f6eb8d-f5dc-4e96-9d23-926ae8cbc20a" name="X_DiproticBaseMonoproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="300e9154-7fee-4ae8-9296-554e35845c7c">
                 <Info flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -1369,8 +1439,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="1f86212c-74fe-4376-ac6a-dc14029c669c" name="X_MonoproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="0bc3f532-dde5-4a9d-8640-c2abc786f9e6">
+              <Parameter id="e650edfe-b1fd-4839-ab96-0e68f2f87ee6" name="X_MonoproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="caae8db2-caa4-484d-91cb-b717e15a7e75">
                 <Info flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -1379,8 +1450,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="e3f07327-3ed3-48ab-a593-725e13f54165" name="X_MonoproticBase" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="6991994d-1616-4ba9-a8da-1051b5e55cad">
+              <Parameter id="e9b74bad-ae10-4c88-ad11-b3edbf28e70c" name="X_MonoproticBase" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="cbf18a25-bc87-403a-ad5a-a63c02f25010">
                 <Info flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -1389,8 +1461,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="bd57e695-09d8-4dec-8a2a-502f0e3d96d6" name="X_MonoproticBaseDiproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="ae324cec-c6d3-49db-b3fd-50b5eb692d34">
+              <Parameter id="4796afec-4988-437b-80ae-4f5a064a6a25" name="X_MonoproticBaseDiproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="73087907-820b-445e-b7d3-94e2596623f0">
                 <Info flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -1399,8 +1472,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="c8069dfe-7ae4-45ee-ab1a-cf735b718e1e" name="X_MonoproticBaseMonoproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="72bbff26-e935-4a88-ba18-e5455d17352b">
+              <Parameter id="b3469a8b-605b-4139-8a79-d50af30d68c8" name="X_MonoproticBaseMonoproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="7eafcfa5-72ca-4851-a4cf-df6ee3737192">
                 <Info flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -1409,8 +1483,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="b775e85b-5557-480e-8469-1df681a02b45" name="X_Neutral" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" value="0">
+              <Parameter id="9a8e9e71-34b8-49f8-a452-1ffd7711e03f" name="X_Neutral" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" value="0">
                 <Info flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -1419,8 +1494,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="1820b2eb-4ae1-43c3-a820-3bfcd508d6c1" name="X_TriproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="0eaadf16-d34a-4de8-9472-d50651b24426">
+              <Parameter id="f940fec9-20c3-465f-94ea-f1b2dcf36e81" name="X_TriproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="61c9a1b7-241f-4be4-a4c6-1b17efce4bbf">
                 <Info flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -1429,8 +1505,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="3d7b6860-9229-4913-894d-10c14b9f8770" name="X_TriproticBase" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="39c2b927-91bf-4707-b5f4-c1208c0c68a7">
+              <Parameter id="26c76088-586a-40a6-88de-bb039e685492" name="X_TriproticBase" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="c1d697fa-e5e3-4739-8df2-930131c2156e">
                 <Info flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -1439,8 +1516,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="6cd2cf45-263b-4ec6-922f-8be80e28f64d" name="Y" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="4daa64cd-affd-452b-b579-094d0c172df5">
+              <Parameter id="d9f1448f-b11c-4d2d-8986-e94ff905e06b" name="Y" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="bde7a11b-2832-41ed-bc40-f39e5773818f">
                 <Info flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -1449,8 +1527,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="f5e098c4-fe0b-472f-a4bc-404c6667274f" name="Y_DiproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="4b7909f5-e3e8-41ee-ad35-9c2649eef6cd">
+              <Parameter id="1a0b7dc2-d1db-4d88-abe9-c1f8051c66f4" name="Y_DiproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="bc83a82d-22a4-449b-bd15-6aad1ec267c0">
                 <Info flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -1459,8 +1538,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="1a06d07f-c399-4585-9a0c-49593f488ad3" name="Y_DiproticBase" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="1e265c21-0aa7-42fd-b4d0-ecdc5fe3205b">
+              <Parameter id="2dbf5902-d5fc-4de7-9ba5-cea294971771" name="Y_DiproticBase" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="9e92e408-71ac-4c40-9cb6-58e9cf853bf8">
                 <Info flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -1469,8 +1549,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="4e8b48d9-2ac3-479f-b00e-c6f639e5890e" name="Y_DiproticBaseMonoproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="054475dc-e1ca-49d7-af7c-5ccc862db6c7">
+              <Parameter id="17b4d718-dad4-45cb-a7dd-f5b030a6b98e" name="Y_DiproticBaseMonoproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="e2072e37-5ee0-4b4a-aba1-cd5d2acd512a">
                 <Info flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -1479,8 +1560,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="a6b3ec38-0d88-4519-8561-638f6ed63959" name="Y_MonoproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="410d328c-705f-4226-be55-5149ce3c35a9">
+              <Parameter id="d03b73a8-10a6-4e85-9364-2b9286548fec" name="Y_MonoproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="1bede4d9-c810-4dcf-89fb-35cdc0fd0590">
                 <Info flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -1489,8 +1571,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="415bfe01-29df-488d-b902-65de1adde333" name="Y_MonoproticBase" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="87ba0736-54a1-4dd0-aede-4e4b3f1efd40">
+              <Parameter id="bef22e86-40d7-49b1-beff-0dff7008f22f" name="Y_MonoproticBase" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="0ebbc342-bca8-49f2-82a2-c293a5fcf741">
                 <Info flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -1499,8 +1582,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="7cdaaa88-d620-49ca-9e65-6de36b06a0f1" name="Y_MonoproticBaseDiproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="d7fd2511-0bf2-474c-ac22-f1ef86217550">
+              <Parameter id="0064747f-95e1-41d0-a58a-90fa9bbd5564" name="Y_MonoproticBaseDiproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="b76ea9ed-b7e3-431d-805b-106887832ae8">
                 <Info flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -1509,8 +1593,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="1cc767cc-0e76-407c-b63d-8661ecd87f76" name="Y_MonoproticBaseMonoproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="5a641325-0e86-4922-a959-74049f12d2a0">
+              <Parameter id="2acb6a37-9375-4542-b851-bd523201fd3e" name="Y_MonoproticBaseMonoproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="92623792-cb23-4622-83e7-cfaf477af4cb">
                 <Info flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -1519,8 +1604,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="33f825f5-995b-4e6e-84e7-6b97e368ed76" name="Y_Neutral" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" value="0">
+              <Parameter id="84d526a8-53d2-4369-9bb3-1a51ba3280a7" name="Y_Neutral" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" value="0">
                 <Info flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -1529,8 +1615,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="bf938119-b66e-4d47-a8c1-603755953868" name="Y_TriproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="0c3b6619-e4c1-42cf-9c25-9d639d15b7c6">
+              <Parameter id="cf5e0834-eebe-4f6b-af08-76f6b494e650" name="Y_TriproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="881fd143-2cc0-4f45-ba39-ab6af39b7e8d">
                 <Info flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -1539,8 +1626,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="848d1fd2-6c84-4103-8448-97dd71b0f607" name="Y_TriproticBase" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="6270cfd6-8d78-4011-9c20-1b505c3574dc">
+              <Parameter id="fd0eb87f-5bb0-419b-89f6-e463835714b7" name="Y_TriproticBase" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="434d4eef-ab55-433d-b0f2-a2bfaaf55c3e">
                 <Info flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -1549,8 +1637,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="dbeebc27-b588-435a-bc82-3184109726e4" name="Z" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="1b00fbec-6c54-4454-b150-74395387ecda">
+              <Parameter id="88809c15-f91d-4ed2-925c-e08da603b995" name="Z" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="322ec775-5027-4747-b940-ab7ea6b7b29d">
                 <Info flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -1559,8 +1648,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="0da7b9b8-60ef-427d-ba44-7144bce835b7" name="Z_DiproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="e78cdbe2-061c-4e8f-846d-a8f5cfe2d82b">
+              <Parameter id="b67eb44b-3146-4019-b57f-f9fdaf583412" name="Z_DiproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="64e66ff9-0dc0-41c0-8628-6304b68dc217">
                 <Info flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -1569,8 +1659,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="96cfb51e-ed35-4a50-a638-abf8690c02f6" name="Z_DiproticBase" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="acef10f8-c7c3-48c9-a62f-864cac0c32d3">
+              <Parameter id="79b5c99e-99ea-42c2-89c2-1c274b5d9135" name="Z_DiproticBase" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="a275eb37-7e00-473c-95be-e863d75960f7">
                 <Info flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -1579,8 +1670,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="897731c3-6b45-4d14-b36f-6afda2c2e2b6" name="Z_DiproticBaseMonoproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="30315783-0e53-44f7-b396-b9c2cc6bb0c7">
+              <Parameter id="19cc80af-a764-4030-a7bd-746899bb3e0b" name="Z_DiproticBaseMonoproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="aace7c2f-6db4-437c-ba09-a2dd6cfd50a4">
                 <Info flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -1589,8 +1681,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="80015752-0796-4d31-a920-34be3b0a7624" name="Z_MonoproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="3d63041b-3bab-4a79-92f7-5a092f79942b">
+              <Parameter id="01c46658-1924-4f73-81d9-5a78a651f7a3" name="Z_MonoproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="6454a459-9c0e-4da2-93d1-b4f988202fbd">
                 <Info flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -1599,8 +1692,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="1a7a501b-6464-4e8d-9b4f-b1202a09ee32" name="Z_MonoproticBase" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="8aba0ece-f44c-4c07-9b4d-0e18e6948dcd">
+              <Parameter id="64976f69-9fc2-4532-89b9-7b2307f7bb2d" name="Z_MonoproticBase" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="c8133e87-2071-4580-a3a3-1a246b8be9e6">
                 <Info flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -1609,8 +1703,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="558edca4-b17c-4156-8847-ee44057520b2" name="Z_MonoproticBaseDiproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="e1d089f9-1a3f-436b-a7f2-fc4de8a83d74">
+              <Parameter id="f71f6b79-efba-44ed-abba-7c59fffe69bf" name="Z_MonoproticBaseDiproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="46366d57-2532-4b3e-80a3-486b54e07f06">
                 <Info flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -1619,8 +1714,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="cea49a69-51c0-455a-8f32-15aec4f2113f" name="Z_MonoproticBaseMonoproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="e641ba43-4277-4c23-8d14-e25e80197a9d">
+              <Parameter id="b9524f87-ec0a-420d-8472-57249b820c64" name="Z_MonoproticBaseMonoproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="3a4d03d5-167a-41fd-bf55-f80e96532f69">
                 <Info flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -1629,8 +1725,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="0a22ba9f-9fb6-4038-a44b-d586d831dbab" name="Z_Neutral" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="e9962867-ff46-4b72-9124-6518fdb47e21">
+              <Parameter id="da64fb5e-6336-4a12-ad11-2a946dadb2e7" name="Z_Neutral" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="74045781-cf40-44a2-96ae-9d48ba6e9ccb">
                 <Info flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -1639,8 +1736,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="f6205ef4-27ab-4dc6-9b3d-fa946880d350" name="Z_TriproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="67f7cb09-dd50-4762-a127-3e7aa7e4424c">
+              <Parameter id="28a9df73-076a-4401-b902-e80cd57ed4fc" name="Z_TriproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="86c42647-40e0-4572-8627-ddce80a3c3ee">
                 <Info flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -1649,8 +1747,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="1d684ab8-3f68-48f6-9e55-022ac3fbe648" name="Z_TriproticBase" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="06172fae-73c3-4936-ba82-a95972e83c6d">
+              <Parameter id="cc46177b-67ff-4e5f-b431-c4d0e618a7c1" name="Z_TriproticBase" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="db7b44bb-3f9f-431c-80ea-0eedb7e791a4">
                 <Info flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -1661,7 +1760,7 @@
           </HelpParameters>
           <FormulaCache>
             <Formulas>
-              <Formula id="280539b5-bc8b-49ba-8045-01e2890e626c" name="PARAM_Ka_AP" formula="Max(0;Kpu_bc - (1+Z)/(1+Y)*f_iw_bc - (10^LogP*f_nl_bc + (0.3*10^LogP+0.7)*f_np_bc)/(1+Y)) * (1+Y) / AP_bc / Z">
+              <Formula id="1b2dd07b-0be8-446b-a483-47521082ab2d" name="PARAM_Ka_AP" formula="Max(0;Kpu_bc - (1+Z)/(1+Y)*f_iw_bc - (10^LogP*f_nl_bc + (0.3*10^LogP+0.7)*f_np_bc)/(1+Y)) * (1+Y) / AP_bc / Z">
                 <Paths>
                   <Path path="13" as="14" dim="15" />
                   <Path path="3" as="36" />
@@ -1674,7 +1773,7 @@
                   <Path path="45" as="46" />
                 </Paths>
               </Formula>
-              <Formula id="873c8d7d-bded-49f8-bcce-3f5ee44a346f" name="PARAM_Ka_PR" formula="Max(0;1/fu - 1 - (10^LogP*f_nl_p + (0.3*10^LogP+0.7)*f_np_p)/(1+Y))">
+              <Formula id="c4bff630-d5d7-4af8-a13e-a1141bcfb956" name="PARAM_Ka_PR" formula="Max(0;1/fu - 1 - (10^LogP*f_nl_p + (0.3*10^LogP+0.7)*f_np_p)/(1+Y))">
                 <Paths>
                   <Path path="0" as="1" dim="2" />
                   <Path path="13" as="14" dim="15" />
@@ -1684,19 +1783,19 @@
                   <Path path="49" as="50" />
                 </Paths>
               </Formula>
-              <Formula id="d4bf723e-6f32-40d2-8685-46ed58fd3c6e" name="PARAM_LogP_ow" dim="Log Units" formula="1.115 * LogP - 1.35">
+              <Formula id="61306e17-a13a-40fd-ba93-2036873be0ac" name="PARAM_LogP_ow" dim="Log Units" formula="1.115 * LogP - 1.35">
                 <Paths>
                   <Path path="13" as="14" dim="15" />
                 </Paths>
               </Formula>
-              <Formula id="6765a8f0-0182-43bd-aeb2-33db9bac005e" name="PARAM_Kpu_bc" formula="(HCT - 1 + B2P) / fu / HCT">
+              <Formula id="88cd0c4d-c77e-4c1e-93a6-cf8e0ec0860a" name="PARAM_Kpu_bc" formula="(HCT - 1 + B2P) / fu / HCT">
                 <Paths>
                   <Path path="51" as="52" />
                   <Path path="0" as="1" dim="2" />
                   <Path path="53" as="54" />
                 </Paths>
               </Formula>
-              <Formula id="402a0f0c-cb4a-434c-8773-0af8eb4fc420" name="PARAM_X" formula="X_Neutral + X_MonoproticBase + X_MonoproticAcid + X_DiproticBase + X_DiproticAcid + X_MonoproticBaseMonoproticAcid + X_TriproticAcid + X_TriproticBase + X_DiproticBaseMonoproticAcid + X_MonoproticBaseDiproticAcid">
+              <Formula id="41de144b-c62e-4e50-a46a-cbffa2f6b942" name="PARAM_X" formula="X_Neutral + X_MonoproticBase + X_MonoproticAcid + X_DiproticBase + X_DiproticAcid + X_MonoproticBaseMonoproticAcid + X_TriproticAcid + X_TriproticBase + X_DiproticBaseMonoproticAcid + X_MonoproticBaseDiproticAcid">
                 <Paths>
                   <Path path="55" as="56" />
                   <Path path="57" as="58" />
@@ -1710,7 +1809,7 @@
                   <Path path="73" as="74" />
                 </Paths>
               </Formula>
-              <Formula id="ee95bbfd-47a5-41c5-9886-6ee3831d2ecc" name="PARAM_X_DiproticAcid" formula="IsDiproticAcid ? 10^(pH_IW-pKa_Acid_0) + 10^(2*pH_IW-pKa_Acid_0-pKa_Acid_1) : 0">
+              <Formula id="0a88b366-360f-47eb-a6ff-218e4e5f7c65" name="PARAM_X_DiproticAcid" formula="IsDiproticAcid ? 10^(pH_IW-pKa_Acid_0) + 10^(2*pH_IW-pKa_Acid_0-pKa_Acid_1) : 0">
                 <Paths>
                   <Path path="75" as="76" />
                   <Path path="77" as="78" />
@@ -1718,7 +1817,7 @@
                   <Path path="81" as="82" />
                 </Paths>
               </Formula>
-              <Formula id="9f217174-95f9-40db-86ab-05a6e7ee2a8d" name="PARAM_X_DiproticBase" formula="IsDiproticBase ? 10^(pKa_Base_1-pH_IW) + 10^(pKa_Base_0+pKa_Base_1-2*pH_IW) : 0">
+              <Formula id="f1a955e6-d411-4950-acda-50c036a88d74" name="PARAM_X_DiproticBase" formula="IsDiproticBase ? 10^(pKa_Base_1-pH_IW) + 10^(pKa_Base_0+pKa_Base_1-2*pH_IW) : 0">
                 <Paths>
                   <Path path="83" as="84" />
                   <Path path="85" as="86" />
@@ -1726,7 +1825,7 @@
                   <Path path="81" as="82" />
                 </Paths>
               </Formula>
-              <Formula id="b5270c9e-5f71-4b8f-937c-264b13bd3760" name="PARAM_X_DiproticBaseMonoproticAcid" formula="IsDiproticBaseMonoproticAcid ? 10^(pH_IW-pKa_Acid_0) + 10^(pKa_Base_1-pH_IW) + 10^(pKa_Base_0+pKa_Base_1-2*pH_IW) : 0">
+              <Formula id="300e9154-7fee-4ae8-9296-554e35845c7c" name="PARAM_X_DiproticBaseMonoproticAcid" formula="IsDiproticBaseMonoproticAcid ? 10^(pH_IW-pKa_Acid_0) + 10^(pKa_Base_1-pH_IW) + 10^(pKa_Base_0+pKa_Base_1-2*pH_IW) : 0">
                 <Paths>
                   <Path path="89" as="90" />
                   <Path path="77" as="78" />
@@ -1735,21 +1834,21 @@
                   <Path path="81" as="82" />
                 </Paths>
               </Formula>
-              <Formula id="0bc3f532-dde5-4a9d-8640-c2abc786f9e6" name="PARAM_X_MonoproticAcid" formula="IsMonoproticAcid ? 10^(pH_IW-pKa_Acid_0) : 0">
+              <Formula id="caae8db2-caa4-484d-91cb-b717e15a7e75" name="PARAM_X_MonoproticAcid" formula="IsMonoproticAcid ? 10^(pH_IW-pKa_Acid_0) : 0">
                 <Paths>
                   <Path path="91" as="92" />
                   <Path path="77" as="78" />
                   <Path path="81" as="82" />
                 </Paths>
               </Formula>
-              <Formula id="6991994d-1616-4ba9-a8da-1051b5e55cad" name="PARAM_X_MonoproticBase" formula="IsMonoproticBase ? 10^(pKa_Base_0-pH_IW) : 0">
+              <Formula id="cbf18a25-bc87-403a-ad5a-a63c02f25010" name="PARAM_X_MonoproticBase" formula="IsMonoproticBase ? 10^(pKa_Base_0-pH_IW) : 0">
                 <Paths>
                   <Path path="93" as="94" />
                   <Path path="85" as="86" />
                   <Path path="81" as="82" />
                 </Paths>
               </Formula>
-              <Formula id="ae324cec-c6d3-49db-b3fd-50b5eb692d34" name="PARAM_X_MonoproticBaseDiproticAcid" formula="IsMonoproticBaseDiproticAcid ? 10^(pKa_Base_0-pH_IW) + 10^(pH_IW-pKa_Acid_0) + 10^(2*pH_IW-pKa_Acid_0-pKa_Acid_1) : 0">
+              <Formula id="73087907-820b-445e-b7d3-94e2596623f0" name="PARAM_X_MonoproticBaseDiproticAcid" formula="IsMonoproticBaseDiproticAcid ? 10^(pKa_Base_0-pH_IW) + 10^(pH_IW-pKa_Acid_0) + 10^(2*pH_IW-pKa_Acid_0-pKa_Acid_1) : 0">
                 <Paths>
                   <Path path="95" as="96" />
                   <Path path="77" as="78" />
@@ -1758,7 +1857,7 @@
                   <Path path="81" as="82" />
                 </Paths>
               </Formula>
-              <Formula id="72bbff26-e935-4a88-ba18-e5455d17352b" name="PARAM_X_MonoproticBaseMonoproticAcid" formula="IsMonoproticBaseMonoproticAcid ? 10^(pKa_Base_0-pH_IW) + 10^(pH_IW-pKa_Acid_0) : 0">
+              <Formula id="7eafcfa5-72ca-4851-a4cf-df6ee3737192" name="PARAM_X_MonoproticBaseMonoproticAcid" formula="IsMonoproticBaseMonoproticAcid ? 10^(pKa_Base_0-pH_IW) + 10^(pH_IW-pKa_Acid_0) : 0">
                 <Paths>
                   <Path path="97" as="98" />
                   <Path path="77" as="78" />
@@ -1766,7 +1865,7 @@
                   <Path path="81" as="82" />
                 </Paths>
               </Formula>
-              <Formula id="0eaadf16-d34a-4de8-9472-d50651b24426" name="PARAM_X_TriproticAcid" formula="IsTriproticAcid ? 10^(pH_IW-pKa_Acid_0) + 10^(2*pH_IW-pKa_Acid_0-pKa_Acid_1) + 10^(3*pH_IW-pKa_Acid_0-pKa_Acid_1-pKa_Acid_2) : 0">
+              <Formula id="61c9a1b7-241f-4be4-a4c6-1b17efce4bbf" name="PARAM_X_TriproticAcid" formula="IsTriproticAcid ? 10^(pH_IW-pKa_Acid_0) + 10^(2*pH_IW-pKa_Acid_0-pKa_Acid_1) + 10^(3*pH_IW-pKa_Acid_0-pKa_Acid_1-pKa_Acid_2) : 0">
                 <Paths>
                   <Path path="99" as="100" />
                   <Path path="77" as="78" />
@@ -1775,7 +1874,7 @@
                   <Path path="81" as="82" />
                 </Paths>
               </Formula>
-              <Formula id="39c2b927-91bf-4707-b5f4-c1208c0c68a7" name="PARAM_X_TriproticBase" formula="IsTriproticBase ? 10^(pKa_Base_2-pH_IW) + 10^(pKa_Base_2+pKa_Base_1-2*pH_IW) + 10^(pKa_Base_0+pKa_Base_1+pKa_Base_2-3*pH_IW) : 0">
+              <Formula id="c1d697fa-e5e3-4739-8df2-930131c2156e" name="PARAM_X_TriproticBase" formula="IsTriproticBase ? 10^(pKa_Base_2-pH_IW) + 10^(pKa_Base_2+pKa_Base_1-2*pH_IW) + 10^(pKa_Base_0+pKa_Base_1+pKa_Base_2-3*pH_IW) : 0">
                 <Paths>
                   <Path path="103" as="104" />
                   <Path path="85" as="86" />
@@ -1784,7 +1883,7 @@
                   <Path path="81" as="82" />
                 </Paths>
               </Formula>
-              <Formula id="4daa64cd-affd-452b-b579-094d0c172df5" name="PARAM_Y" formula="Y_Neutral + Y_MonoproticBase + Y_MonoproticAcid + Y_DiproticBase + Y_DiproticAcid + Y_MonoproticBaseMonoproticAcid + Y_TriproticAcid + Y_TriproticBase + Y_DiproticBaseMonoproticAcid + Y_MonoproticBaseDiproticAcid">
+              <Formula id="bde7a11b-2832-41ed-bc40-f39e5773818f" name="PARAM_Y" formula="Y_Neutral + Y_MonoproticBase + Y_MonoproticAcid + Y_DiproticBase + Y_DiproticAcid + Y_MonoproticBaseMonoproticAcid + Y_TriproticAcid + Y_TriproticBase + Y_DiproticBaseMonoproticAcid + Y_MonoproticBaseDiproticAcid">
                 <Paths>
                   <Path path="107" as="108" />
                   <Path path="109" as="110" />
@@ -1798,7 +1897,7 @@
                   <Path path="125" as="126" />
                 </Paths>
               </Formula>
-              <Formula id="4b7909f5-e3e8-41ee-ad35-9c2649eef6cd" name="PARAM_Y_DiproticAcid" formula="IsDiproticAcid ? 10^(pH_PLS-pKa_Acid_0) + 10^(2*pH_PLS-pKa_Acid_0-pKa_Acid_1) : 0">
+              <Formula id="bc83a82d-22a4-449b-bd15-6aad1ec267c0" name="PARAM_Y_DiproticAcid" formula="IsDiproticAcid ? 10^(pH_PLS-pKa_Acid_0) + 10^(2*pH_PLS-pKa_Acid_0-pKa_Acid_1) : 0">
                 <Paths>
                   <Path path="75" as="76" />
                   <Path path="77" as="78" />
@@ -1806,7 +1905,7 @@
                   <Path path="127" as="128" />
                 </Paths>
               </Formula>
-              <Formula id="1e265c21-0aa7-42fd-b4d0-ecdc5fe3205b" name="PARAM_Y_DiproticBase" formula="IsDiproticBase ? 10^(pKa_Base_1-pH_PLS) + 10^(pKa_Base_0+pKa_Base_1-2*pH_PLS) : 0">
+              <Formula id="9e92e408-71ac-4c40-9cb6-58e9cf853bf8" name="PARAM_Y_DiproticBase" formula="IsDiproticBase ? 10^(pKa_Base_1-pH_PLS) + 10^(pKa_Base_0+pKa_Base_1-2*pH_PLS) : 0">
                 <Paths>
                   <Path path="83" as="84" />
                   <Path path="85" as="86" />
@@ -1814,7 +1913,7 @@
                   <Path path="127" as="128" />
                 </Paths>
               </Formula>
-              <Formula id="054475dc-e1ca-49d7-af7c-5ccc862db6c7" name="PARAM_Y_DiproticBaseMonoproticAcid" formula="IsDiproticBaseMonoproticAcid ? 10^(pH_PLS-pKa_Acid_0) + 10^(pKa_Base_1-pH_PLS) + 10^(pKa_Base_0+pKa_Base_1-2*pH_PLS) : 0">
+              <Formula id="e2072e37-5ee0-4b4a-aba1-cd5d2acd512a" name="PARAM_Y_DiproticBaseMonoproticAcid" formula="IsDiproticBaseMonoproticAcid ? 10^(pH_PLS-pKa_Acid_0) + 10^(pKa_Base_1-pH_PLS) + 10^(pKa_Base_0+pKa_Base_1-2*pH_PLS) : 0">
                 <Paths>
                   <Path path="89" as="90" />
                   <Path path="77" as="78" />
@@ -1823,21 +1922,21 @@
                   <Path path="127" as="128" />
                 </Paths>
               </Formula>
-              <Formula id="410d328c-705f-4226-be55-5149ce3c35a9" name="PARAM_Y_MonoproticAcid" formula="IsMonoproticAcid ? 10^(pH_PLS-pKa_Acid_0) : 0">
+              <Formula id="1bede4d9-c810-4dcf-89fb-35cdc0fd0590" name="PARAM_Y_MonoproticAcid" formula="IsMonoproticAcid ? 10^(pH_PLS-pKa_Acid_0) : 0">
                 <Paths>
                   <Path path="91" as="92" />
                   <Path path="77" as="78" />
                   <Path path="127" as="128" />
                 </Paths>
               </Formula>
-              <Formula id="87ba0736-54a1-4dd0-aede-4e4b3f1efd40" name="PARAM_Y_MonoproticBase" formula="IsMonoproticBase ? 10^(pKa_Base_0-pH_PLS) : 0">
+              <Formula id="0ebbc342-bca8-49f2-82a2-c293a5fcf741" name="PARAM_Y_MonoproticBase" formula="IsMonoproticBase ? 10^(pKa_Base_0-pH_PLS) : 0">
                 <Paths>
                   <Path path="93" as="94" />
                   <Path path="85" as="86" />
                   <Path path="127" as="128" />
                 </Paths>
               </Formula>
-              <Formula id="d7fd2511-0bf2-474c-ac22-f1ef86217550" name="PARAM_Y_MonoproticBaseDiproticAcid" formula="IsMonoproticBaseDiproticAcid ? 10^(pKa_Base_0-pH_PLS) + 10^(pH_PLS-pKa_Acid_0) + 10^(2*pH_PLS-pKa_Acid_0-pKa_Acid_1) : 0">
+              <Formula id="b76ea9ed-b7e3-431d-805b-106887832ae8" name="PARAM_Y_MonoproticBaseDiproticAcid" formula="IsMonoproticBaseDiproticAcid ? 10^(pKa_Base_0-pH_PLS) + 10^(pH_PLS-pKa_Acid_0) + 10^(2*pH_PLS-pKa_Acid_0-pKa_Acid_1) : 0">
                 <Paths>
                   <Path path="95" as="96" />
                   <Path path="77" as="78" />
@@ -1846,7 +1945,7 @@
                   <Path path="127" as="128" />
                 </Paths>
               </Formula>
-              <Formula id="5a641325-0e86-4922-a959-74049f12d2a0" name="PARAM_Y_MonoproticBaseMonoproticAcid" formula="IsMonoproticBaseMonoproticAcid ? 10^(pKa_Base_0-pH_PLS) + 10^(pH_PLS-pKa_Acid_0) : 0">
+              <Formula id="92623792-cb23-4622-83e7-cfaf477af4cb" name="PARAM_Y_MonoproticBaseMonoproticAcid" formula="IsMonoproticBaseMonoproticAcid ? 10^(pKa_Base_0-pH_PLS) + 10^(pH_PLS-pKa_Acid_0) : 0">
                 <Paths>
                   <Path path="97" as="98" />
                   <Path path="77" as="78" />
@@ -1854,7 +1953,7 @@
                   <Path path="127" as="128" />
                 </Paths>
               </Formula>
-              <Formula id="0c3b6619-e4c1-42cf-9c25-9d639d15b7c6" name="PARAM_Y_TriproticAcid" formula="IsTriproticAcid ? 10^(pH_PLS-pKa_Acid_0) + 10^(2*pH_PLS-pKa_Acid_0-pKa_Acid_1) + 10^(3*pH_PLS-pKa_Acid_0-pKa_Acid_1-pKa_Acid_2) : 0">
+              <Formula id="881fd143-2cc0-4f45-ba39-ab6af39b7e8d" name="PARAM_Y_TriproticAcid" formula="IsTriproticAcid ? 10^(pH_PLS-pKa_Acid_0) + 10^(2*pH_PLS-pKa_Acid_0-pKa_Acid_1) + 10^(3*pH_PLS-pKa_Acid_0-pKa_Acid_1-pKa_Acid_2) : 0">
                 <Paths>
                   <Path path="99" as="100" />
                   <Path path="77" as="78" />
@@ -1863,7 +1962,7 @@
                   <Path path="127" as="128" />
                 </Paths>
               </Formula>
-              <Formula id="6270cfd6-8d78-4011-9c20-1b505c3574dc" name="PARAM_Y_TriproticBase" formula="IsTriproticBase ? 10^(pKa_Base_2-pH_PLS) + 10^(pKa_Base_2+pKa_Base_1-2*pH_PLS) + 10^(pKa_Base_0+pKa_Base_1+pKa_Base_2-3*pH_PLS) : 0">
+              <Formula id="434d4eef-ab55-433d-b0f2-a2bfaaf55c3e" name="PARAM_Y_TriproticBase" formula="IsTriproticBase ? 10^(pKa_Base_2-pH_PLS) + 10^(pKa_Base_2+pKa_Base_1-2*pH_PLS) + 10^(pKa_Base_0+pKa_Base_1+pKa_Base_2-3*pH_PLS) : 0">
                 <Paths>
                   <Path path="103" as="104" />
                   <Path path="85" as="86" />
@@ -1872,7 +1971,7 @@
                   <Path path="127" as="128" />
                 </Paths>
               </Formula>
-              <Formula id="1b00fbec-6c54-4454-b150-74395387ecda" name="PARAM_Z" formula="Z_Neutral + Z_MonoproticBase + Z_MonoproticAcid + Z_DiproticBase + Z_DiproticAcid + Z_MonoproticBaseMonoproticAcid + Z_TriproticAcid + Z_TriproticBase + Z_DiproticBaseMonoproticAcid + Z_MonoproticBaseDiproticAcid">
+              <Formula id="322ec775-5027-4747-b940-ab7ea6b7b29d" name="PARAM_Z" formula="Z_Neutral + Z_MonoproticBase + Z_MonoproticAcid + Z_DiproticBase + Z_DiproticAcid + Z_MonoproticBaseMonoproticAcid + Z_TriproticAcid + Z_TriproticBase + Z_DiproticBaseMonoproticAcid + Z_MonoproticBaseDiproticAcid">
                 <Paths>
                   <Path path="129" as="130" />
                   <Path path="131" as="132" />
@@ -1886,12 +1985,12 @@
                   <Path path="147" as="148" />
                 </Paths>
               </Formula>
-              <Formula id="e78cdbe2-061c-4e8f-846d-a8f5cfe2d82b" name="PARAM_Z_DiproticAcid" formula="IsDiproticAcid ? 1 : 0">
+              <Formula id="64e66ff9-0dc0-41c0-8628-6304b68dc217" name="PARAM_Z_DiproticAcid" formula="IsDiproticAcid ? 1 : 0">
                 <Paths>
                   <Path path="75" as="76" />
                 </Paths>
               </Formula>
-              <Formula id="acef10f8-c7c3-48c9-a62f-864cac0c32d3" name="PARAM_Z_DiproticBase" formula="IsDiproticBase ? 10^(pKa_Base_1-pH_RBC) + 10^(pKa_Base_0+pKa_Base_1-2*pH_RBC) : 0">
+              <Formula id="a275eb37-7e00-473c-95be-e863d75960f7" name="PARAM_Z_DiproticBase" formula="IsDiproticBase ? 10^(pKa_Base_1-pH_RBC) + 10^(pKa_Base_0+pKa_Base_1-2*pH_RBC) : 0">
                 <Paths>
                   <Path path="83" as="84" />
                   <Path path="85" as="86" />
@@ -1899,7 +1998,7 @@
                   <Path path="149" as="150" />
                 </Paths>
               </Formula>
-              <Formula id="30315783-0e53-44f7-b396-b9c2cc6bb0c7" name="PARAM_Z_DiproticBaseMonoproticAcid" formula="IsDiproticBaseMonoproticAcid ? 10^(pH_RBC-pKa_Acid_0) + 10^(pKa_Base_1-pH_RBC) + 10^(pKa_Base_0+pKa_Base_1-2*pH_RBC) : 0">
+              <Formula id="aace7c2f-6db4-437c-ba09-a2dd6cfd50a4" name="PARAM_Z_DiproticBaseMonoproticAcid" formula="IsDiproticBaseMonoproticAcid ? 10^(pH_RBC-pKa_Acid_0) + 10^(pKa_Base_1-pH_RBC) + 10^(pKa_Base_0+pKa_Base_1-2*pH_RBC) : 0">
                 <Paths>
                   <Path path="89" as="90" />
                   <Path path="77" as="78" />
@@ -1908,19 +2007,19 @@
                   <Path path="149" as="150" />
                 </Paths>
               </Formula>
-              <Formula id="3d63041b-3bab-4a79-92f7-5a092f79942b" name="PARAM_Z_MonoproticAcid" formula="IsMonoproticAcid ? 1 : 0">
+              <Formula id="6454a459-9c0e-4da2-93d1-b4f988202fbd" name="PARAM_Z_MonoproticAcid" formula="IsMonoproticAcid ? 1 : 0">
                 <Paths>
                   <Path path="91" as="92" />
                 </Paths>
               </Formula>
-              <Formula id="8aba0ece-f44c-4c07-9b4d-0e18e6948dcd" name="PARAM_Z_MonoproticBase" formula="IsMonoproticBase ? 10^(pKa_Base_0-pH_RBC) : 0">
+              <Formula id="c8133e87-2071-4580-a3a3-1a246b8be9e6" name="PARAM_Z_MonoproticBase" formula="IsMonoproticBase ? 10^(pKa_Base_0-pH_RBC) : 0">
                 <Paths>
                   <Path path="93" as="94" />
                   <Path path="85" as="86" />
                   <Path path="149" as="150" />
                 </Paths>
               </Formula>
-              <Formula id="e1d089f9-1a3f-436b-a7f2-fc4de8a83d74" name="PARAM_Z_MonoproticBaseDiproticAcid" formula="IsMonoproticBaseDiproticAcid ? 10^(pKa_Base_0-pH_RBC) + 10^(pH_RBC-pKa_Acid_0) + 10^(2*pH_RBC-pKa_Acid_0-pKa_Acid_1) : 0">
+              <Formula id="46366d57-2532-4b3e-80a3-486b54e07f06" name="PARAM_Z_MonoproticBaseDiproticAcid" formula="IsMonoproticBaseDiproticAcid ? 10^(pKa_Base_0-pH_RBC) + 10^(pH_RBC-pKa_Acid_0) + 10^(2*pH_RBC-pKa_Acid_0-pKa_Acid_1) : 0">
                 <Paths>
                   <Path path="95" as="96" />
                   <Path path="77" as="78" />
@@ -1929,7 +2028,7 @@
                   <Path path="149" as="150" />
                 </Paths>
               </Formula>
-              <Formula id="e641ba43-4277-4c23-8d14-e25e80197a9d" name="PARAM_Z_MonoproticBaseMonoproticAcid" formula="IsMonoproticBaseMonoproticAcid ? 10^(pKa_Base_0-pH_RBC) + 10^(pH_RBC-pKa_Acid_0) : 0">
+              <Formula id="3a4d03d5-167a-41fd-bf55-f80e96532f69" name="PARAM_Z_MonoproticBaseMonoproticAcid" formula="IsMonoproticBaseMonoproticAcid ? 10^(pKa_Base_0-pH_RBC) + 10^(pH_RBC-pKa_Acid_0) : 0">
                 <Paths>
                   <Path path="97" as="98" />
                   <Path path="77" as="78" />
@@ -1937,17 +2036,17 @@
                   <Path path="149" as="150" />
                 </Paths>
               </Formula>
-              <Formula id="e9962867-ff46-4b72-9124-6518fdb47e21" name="PARAM_Z_Neutral" formula="IsNeutral ? 1 : 0">
+              <Formula id="74045781-cf40-44a2-96ae-9d48ba6e9ccb" name="PARAM_Z_Neutral" formula="IsNeutral ? 1 : 0">
                 <Paths>
                   <Path path="151" as="6" />
                 </Paths>
               </Formula>
-              <Formula id="67f7cb09-dd50-4762-a127-3e7aa7e4424c" name="PARAM_Z_TriproticAcid" formula="IsTriproticAcid ? 1 : 0">
+              <Formula id="86c42647-40e0-4572-8627-ddce80a3c3ee" name="PARAM_Z_TriproticAcid" formula="IsTriproticAcid ? 1 : 0">
                 <Paths>
                   <Path path="99" as="100" />
                 </Paths>
               </Formula>
-              <Formula id="06172fae-73c3-4936-ba82-a95972e83c6d" name="PARAM_Z_TriproticBase" formula="IsTriproticBase ? 10^(pKa_Base_2-pH_RBC) + 10^(pKa_Base_2+pKa_Base_1-2*pH_RBC) + 10^(pKa_Base_0+pKa_Base_1+pKa_Base_2-3*pH_RBC) : 0">
+              <Formula id="db7b44bb-3f9f-431c-80ea-0eedb7e791a4" name="PARAM_Z_TriproticBase" formula="IsTriproticBase ? 10^(pKa_Base_2-pH_RBC) + 10^(pKa_Base_2+pKa_Base_1-2*pH_RBC) + 10^(pKa_Base_0+pKa_Base_1+pKa_Base_2-3*pH_RBC) : 0">
                 <Paths>
                   <Path path="103" as="104" />
                   <Path path="85" as="86" />
@@ -2113,10 +2212,11 @@
             </StringMap>
           </FormulaCache>
         </CoreCalculationMethod>
-        <CoreCalculationMethod id="5322b08b-b20d-472f-8518-b4ae778af05e" name="Cellular partition coefficient method - Schmitt" icon="CoreCalculationMethod" bbVersion="0" category="DistributionCellular">
+        <CoreCalculationMethod id="7d0b5d67-ff14-430f-b920-b5652426d11f" name="Cellular partition coefficient method - Schmitt" icon="CoreCalculationMethod" bbVersion="0" category="DistributionCellular">
+          <Creation createdAt="5248846165144589186" createdBy="Michael" creationMode="New" origin="Other" />
           <OutputFormulas>
             <KeyValue>
-              <Formula id="55adbefe-d047-404c-a35e-011ebc68cb6c" name="PARAM_K_rbc" formula="(f_w + K_n_L * f_nl + K_n_PL * f_np + K_a_PL * AP_BC + KProt * f_proteins) * fu">
+              <Formula id="dbcfca61-0ed6-42a6-8e42-dbac2cae337c" name="PARAM_K_rbc" formula="(f_w + K_n_L * f_nl + K_n_PL * f_np + K_a_PL * AP_BC + KProt * f_proteins) * fu">
                 <Paths>
                   <Path path="0" as="1" dim="2" />
                   <Path path="3" as="4" dim="5" />
@@ -2140,7 +2240,7 @@
               </ParameterDescriptor>
             </KeyValue>
             <KeyValue>
-              <Formula id="06799c49-cd23-47b7-bc48-d74eddb280f1" name="PARAM_K_cell_pls_Schmitt" formula="(f_w + K_n_L * f_nl + K_n_PL * f_np + K_a_PL * AP_T + KProt * f_proteins) * fu">
+              <Formula id="c1a4315a-0eb8-44f7-9e43-525a955eea52" name="PARAM_K_cell_pls_Schmitt" formula="(f_w + K_n_L * f_nl + K_n_PL * f_np + K_a_PL * AP_T + KProt * f_proteins) * fu">
                 <Paths>
                   <Path path="24" as="7" />
                   <Path path="25" as="9" />
@@ -2167,8 +2267,9 @@
           </OutputFormulas>
           <HelpParameters>
             <KeyValue>
-              <Parameter id="389daf86-f5e6-41d7-9605-969702822e7a" name="K_a_PL_pH_Factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="9e0103ce-982e-437a-998d-2fcd5f60b631">
+              <Parameter id="8e96da24-345f-4c5a-ba41-64631b3e0746" name="K_a_PL_pH_Factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="36368705-1133-4803-b547-49675be5c15b">
                 <Info flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -2177,8 +2278,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="c65ce1bf-5f42-4c56-b4f1-8fe3b0318bf5" name="logD at pH (blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Log Units" quantityType="Parameter" formula="3ba6b621-465d-4094-be4f-70cf6bdd64cb" displayUnit="Log Units">
+              <Parameter id="dfc5a318-131b-4787-9546-6de92e3f5680" name="logD at pH (blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Log Units" quantityType="Parameter" negativeValuesAllowed="1" formula="26d06952-daee-467c-a77f-0ea9203d48f1" displayUnit="Log Units">
                 <Info flag="58" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -2187,8 +2289,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="ff46c0f4-2d83-488c-9a5b-3da2a38b7030" name="logD factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="c60111ec-cd3a-40fa-a5f3-6f5339ae1a33">
+              <Parameter id="605d264b-a5b4-4b70-9fb4-02a9c39c63ed" name="logD factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="0f8229a8-9563-4ab5-bea2-47ac8e17dff1">
                 <Info flag="58" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -2197,8 +2300,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="c1794fe8-99d2-4282-adf3-eb78769e1357" name="Partition coefficient (acidic phospholipids/blood cells water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="92f15277-a512-414d-968a-70722b647dfb">
+              <Parameter id="f1e35235-f2c6-47ad-8fc6-c27e34a835a9" name="Partition coefficient (acidic phospholipids/blood cells water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="aacaa849-2087-4338-93ec-669d46f929a0">
                 <Info flag="58" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -2207,8 +2311,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="d6b01fed-65c8-4670-bd1d-4bf32f44191a" name="Partition coefficient (neutral lipids/blood cells water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="4ed0c9f9-411e-4a9b-89ae-e42f4afdfcca">
+              <Parameter id="c887e089-dbb3-45e8-be2f-27bc63044337" name="Partition coefficient (neutral lipids/blood cells water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="aa179bd1-6517-4150-85c2-beac6522c9fa">
                 <Info flag="58" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -2217,8 +2322,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="80105efe-2c78-4426-893a-03ed56faca0e" name="Partition coefficient (neutral phospholipids/blood cells water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="023d251b-fe58-4444-b380-11e0eb3436c1">
+              <Parameter id="75591916-09d8-4731-999f-09813ad25721" name="Partition coefficient (neutral phospholipids/blood cells water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="cd184357-084b-49e1-b953-f9da0b764604">
                 <Info flag="58" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -2227,8 +2333,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="1b74849c-79ae-48a4-951c-3a0eec785bcb" name="pKa_pH_WS_bc_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="15205f86-9b7a-41ae-a51a-44e06080e97e">
+              <Parameter id="f723250e-0f5f-4320-846f-2614a403d8dc" name="pKa_pH_WS_bc_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="5e3b3fca-67b2-4857-bfb0-e6dfedfdc91e">
                 <Info flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -2237,8 +2344,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="300289cd-e426-4d1d-b75c-94e29f9f797b" name="pKa_pH_WS_bc_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="48be4450-ff13-4174-8e92-7a3d3cd11ed7">
+              <Parameter id="f6d15217-ff72-43d0-84da-64a95a6c988c" name="pKa_pH_WS_bc_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="c5f01c3b-9e2b-490b-ab39-45a158d4d092">
                 <Info flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -2247,8 +2355,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="a64bca09-6ce2-47ea-8498-1092b94fe3d4" name="pKa_pH_WS_bc_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="b60a8c6e-b2cb-44f5-afcb-79fd9343818b">
+              <Parameter id="9d3af9b1-42a8-4649-ad2a-bc995f90a537" name="pKa_pH_WS_bc_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="938d6f06-5884-4338-bfd9-f47eb4149f3f">
                 <Info flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -2257,8 +2366,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="fa19bca0-52d5-43fe-bf5b-a446b3a39fe1" name="pKa_pH_WS_bc_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="3526233d-9276-490b-856d-6c2f70030466">
+              <Parameter id="04092948-d9bd-4dca-93ee-5fa890d050c5" name="pKa_pH_WS_bc_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="f7ed0c96-b3e3-489b-a00d-636ba87e09f5">
                 <Info flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -2267,8 +2377,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="7a15c79e-4698-4dfb-8c56-eb13a36a2177" name="pKa_pH_WS_bc_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="277c0496-6123-4ad6-9f0a-8de2479f4d5f">
+              <Parameter id="6a9ae67f-ad68-453e-8686-5703bcbad690" name="pKa_pH_WS_bc_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="f42f726f-ba14-4790-823a-2116046f4a68">
                 <Info flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -2277,8 +2388,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="4bd3d0b2-1e5a-4c18-b333-2b74a46216d5" name="pKa_pH_WS_bc_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="d9679b76-20d5-472f-a04a-4fd046199dad">
+              <Parameter id="1aca3946-6525-4c6d-9f2f-d1bf9a5a0e4c" name="pKa_pH_WS_bc_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="64f5be83-4f00-44ec-811d-09abcae7e392">
                 <Info flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -2287,8 +2399,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="5d8643e8-44a3-4527-b4bf-33e5e67e80bf" name="pKa_pH_WS_bc_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="1df6f3a4-567b-4ffc-8d1f-0102187611cc">
+              <Parameter id="520e9bce-1ac2-49e7-b25a-d13ef27fdb3b" name="pKa_pH_WS_bc_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="b34610f6-0474-4f2d-b39a-4e23bed31a5c">
                 <Info flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -2297,8 +2410,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="094eb603-0346-43e2-8f7a-6836158e9985" name="pKa_pH_WS_bc_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="f747c578-f53b-46f1-aa62-27a56ac5b428">
+              <Parameter id="8d277078-0e7a-4d2c-8029-588cddf573e5" name="pKa_pH_WS_bc_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="4a729114-ddd4-47d3-8bcb-ee243b09dba3">
                 <Info flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -2307,8 +2421,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="b65bdd03-91d3-4c64-8bf4-20051fc84df9" name="pKa_pH_WS_bc_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="48c54548-81f1-4752-a534-58170836afbe">
+              <Parameter id="d7609314-a8c9-4d9c-9455-d2597f0899fd" name="pKa_pH_WS_bc_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="efccce7e-76f6-4df9-a404-cdd04d293ac2">
                 <Info flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -2317,8 +2432,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="8088155f-0920-4a39-9553-c3ead486e9a7" name="pKa_pH_WS_bc_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="f081ca63-403a-43cd-896f-f3a659eddaae">
+              <Parameter id="aa3bc9c0-9b5b-4b76-9af4-0a443f6b2fd7" name="pKa_pH_WS_bc_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="e050215e-0441-44ce-b980-a353fe15906c">
                 <Info flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -2327,8 +2443,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="fecd64a8-54d2-47cf-ace7-a36263b51a4a" name="pKa_pH_WS_bc_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="655d1cab-d38c-48f6-a7f6-723501377e5a">
+              <Parameter id="7c6103e2-60b4-4172-95af-016e869be2d0" name="pKa_pH_WS_bc_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="5ff3131f-5fad-4ec1-8227-ba1424d3d085">
                 <Info flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -2337,8 +2454,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="90e1bc5d-2376-4721-98bf-4c8dea974089" name="K_a_PL_pH_Factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="0f50393c-3b00-473a-af85-ff42cf08cdb4">
+              <Parameter id="fbbff94b-ff71-49fc-bcbf-43d0f5644f6f" name="K_a_PL_pH_Factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="9f6d6817-94c0-4ebf-94d2-6f793f2ea959">
                 <Info flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -2347,8 +2465,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="232d8112-75e1-4582-9372-f48ce316e551" name="logD at pH (intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Log Units" quantityType="Parameter" formula="e67dee69-78d6-48de-ad33-02eef3ec8a32" displayUnit="Log Units">
+              <Parameter id="18ade098-e3b6-4324-9bb2-cfefa267b8f3" name="logD at pH (intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Log Units" quantityType="Parameter" negativeValuesAllowed="1" formula="c307e3a5-424a-4630-86f4-5b780c2d0cbc" displayUnit="Log Units">
                 <Info flag="58" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -2357,8 +2476,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="46195365-913a-4320-9265-7d3cb6090d7a" name="logD factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="00871bf9-456c-410d-a111-865c7961c329">
+              <Parameter id="78bb82da-b8a4-4d83-ac25-74d6bed73f1f" name="logD factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="fe02aad1-24f2-4581-bb1d-43269f0acb55">
                 <Info flag="58" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -2367,8 +2487,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="5ef91175-62ed-4d9e-9686-341c303bf4b8" name="Partition coefficient (acidic phospholipids/intracellular water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="b44d693f-71a1-4a96-a781-451b5a8eec44">
+              <Parameter id="451e6e81-71c2-44fb-87dc-caa1e0f16678" name="Partition coefficient (acidic phospholipids/intracellular water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="16461ccd-246b-4c80-b2ce-12b44b3f9ac6">
                 <Info flag="58" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -2377,8 +2498,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="4a432835-7f9d-4842-a68c-d42bbe83073c" name="Partition coefficient (neutral lipids/intracellular water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="6be389da-44f6-4d7e-8d69-50c89e1ba657">
+              <Parameter id="891e9eef-88dc-4f22-a8c6-7bd4431c072e" name="Partition coefficient (neutral lipids/intracellular water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="950229dc-4610-4950-ae40-0a5c199f0c9a">
                 <Info flag="58" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -2387,8 +2509,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="33fcc5c2-feb1-4b77-a4bd-e5ce0d18cde4" name="Partition coefficient (neutral phospholipids/intracellular water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="081198ea-e7b9-4e5a-b77c-0f9bc96adba1">
+              <Parameter id="ed825579-4839-4c0a-94e8-1d619c8e1e99" name="Partition coefficient (neutral phospholipids/intracellular water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="77d7dd5e-5b02-400f-9ca8-d8fef00a780e">
                 <Info flag="58" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -2397,8 +2520,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="abad174c-c2a3-4eb5-a9e1-98cb48d8e4d0" name="pKa_pH_WS_cell_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="6ae5d58f-439d-4c62-b240-a1b3a42308f5">
+              <Parameter id="ae4e73c0-553a-4bae-8c91-7c878edca6eb" name="pKa_pH_WS_cell_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="da41157c-9f5c-48de-a487-3fe84a8183b3">
                 <Info flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -2407,8 +2531,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="52653783-c9bd-4831-96d4-bb231cba443f" name="pKa_pH_WS_cell_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="9f22607b-a921-417e-85c4-d5853e412242">
+              <Parameter id="052b959a-fb92-4659-a337-4d761f719c2f" name="pKa_pH_WS_cell_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="885986a9-c19d-4eff-9cba-65868b5ebb43">
                 <Info flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -2417,8 +2542,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="e4957fcf-3242-4166-805b-6e62ead925c6" name="pKa_pH_WS_cell_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="08b29b0f-dd96-479a-9a90-6a63596f89de">
+              <Parameter id="e69c1469-81f1-4dfb-9b82-cb989e76b3d9" name="pKa_pH_WS_cell_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="8530c480-02ea-4762-aee1-06315e1c0a09">
                 <Info flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -2427,8 +2553,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="087302ad-6e1a-4c92-9451-e9c994fb35f6" name="pKa_pH_WS_cell_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="f72093fe-15ad-464d-bb2f-d305f6f76003">
+              <Parameter id="d04aa5ca-21c9-4f13-b700-6817adb29237" name="pKa_pH_WS_cell_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="4f8efbe5-9713-4c06-8b2c-7289ff55c5a8">
                 <Info flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -2437,8 +2564,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="7002e00e-6692-4cc5-863f-9068525b2021" name="pKa_pH_WS_cell_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="dde7f7ec-c7ac-4b52-b990-772601c9f04e">
+              <Parameter id="d46be5f4-24f2-4509-b2fa-aefd561a48e1" name="pKa_pH_WS_cell_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="d553c7f8-8bdb-45cd-8dfe-a477954f23ad">
                 <Info flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -2447,8 +2575,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="c15e949c-4099-486a-be6f-8ad7e340346c" name="pKa_pH_WS_cell_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="125950ca-0be3-4766-9aa6-02255d9035fb">
+              <Parameter id="7ddc9ec6-3fa9-40c5-85a8-d608e13197d7" name="pKa_pH_WS_cell_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="155ca4c6-49f6-4f15-a166-93118573438c">
                 <Info flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -2457,8 +2586,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="f7720759-01cf-4b60-928b-70b7a2aa4de0" name="pKa_pH_WS_cell_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="697e3357-6e6e-49b3-a10b-3d1e27566675">
+              <Parameter id="b0e7bbe9-ac13-45ef-87f3-9d42fdcea849" name="pKa_pH_WS_cell_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="fe0a3fed-aa01-44e8-807d-7fde4b014ea1">
                 <Info flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -2467,8 +2597,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="ce9475e5-2c6b-49bd-ac3e-8822dbd045b0" name="pKa_pH_WS_cell_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="3b4ef14a-49b9-4bbe-b8e4-e153cb4a3da0">
+              <Parameter id="5cc71020-1722-4222-8802-2a30375a90ed" name="pKa_pH_WS_cell_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="6ed05fce-b913-44e5-90ea-5303f6892de2">
                 <Info flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -2477,8 +2608,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="b7ce94dd-f668-4646-a6b1-8f72860e9ad5" name="pKa_pH_WS_cell_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="950f061f-63a8-4370-a11d-591a138719fd">
+              <Parameter id="8e7e1157-5ab4-4828-bba4-716382185d35" name="pKa_pH_WS_cell_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="d1b97a01-9d66-42cb-8c10-921b1bc83fc1">
                 <Info flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -2487,8 +2619,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="20c86e81-6b5f-40cb-aa57-4af1aeef7d63" name="pKa_pH_WS_cell_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="ce03ad92-9150-4d21-b042-684d26f813bc">
+              <Parameter id="7a49f24f-6ef8-404e-a8a7-b4315380df95" name="pKa_pH_WS_cell_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="7a79d0af-3bd9-458d-82aa-30cbc0009b1d">
                 <Info flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -2497,8 +2630,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="27df09c3-9120-4c00-8864-4ba8bcdee1b8" name="pKa_pH_WS_cell_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="254f6c41-edbc-4f03-8730-82a56725f64e">
+              <Parameter id="3b62aa2b-8027-4072-b622-f627e2ad8074" name="pKa_pH_WS_cell_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="abcd315b-8e09-4058-a618-81495ffcfea1">
                 <Info flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -2509,7 +2643,7 @@
           </HelpParameters>
           <FormulaCache>
             <Formulas>
-              <Formula id="9e0103ce-982e-437a-998d-2fcd5f60b631" name="PARAM_K_a_PL_pH_Factor_BC" formula="K1+ K2* base ^ CT0 + K3* base ^ CT1+K4 *base^CT2 + K5* base ^ (CT0+CT1) +K6* base ^ (CT0+CT2) +K7* base ^ (CT2+CT1) +K8* base ^ (CT0+CT1+CT2)">
+              <Formula id="36368705-1133-4803-b547-49675be5c15b" name="PARAM_K_a_PL_pH_Factor_BC" formula="K1+ K2* base ^ CT0 + K3* base ^ CT1+K4 *base^CT2 + K5* base ^ (CT0+CT1) +K6* base ^ (CT0+CT2) +K7* base ^ (CT2+CT1) +K8* base ^ (CT0+CT1+CT2)">
                 <Paths>
                   <Path path="37" as="38" />
                   <Path path="39" as="40" />
@@ -2525,7 +2659,7 @@
                   <Path path="59" as="60" />
                 </Paths>
               </Formula>
-              <Formula id="3ba6b621-465d-4094-be4f-70cf6bdd64cb" name="PARAM_LogD_rbc" dim="Log Units" formula="LogP+Log10(logD_Factor)">
+              <Formula id="26d06952-daee-467c-a77f-0ea9203d48f1" name="PARAM_LogD_rbc" dim="Log Units" formula="LogP+Log10(logD_Factor)">
                 <Paths>
                   <Path path="61" as="62" />
                   <Path path="3" as="63" dim="5" />
@@ -2535,7 +2669,7 @@
                   <Path path="70" as="71" />
                 </Paths>
               </Formula>
-              <Formula id="c60111ec-cd3a-40fa-a5f3-6f5339ae1a33" name="PARAM_logD_Factor_RBC" formula="K1+ (K2 +K3 +K4)* base ^ 1 + K5* base ^ max(CT0+CT1;-CT0-CT1) +K6* base ^ max(CT0+CT2;-CT0-CT2) +K7* base ^ max(CT2+CT1;-CT2-CT1) +K8* base ^ max(CT0+CT1+CT2;-CT0-CT1-CT2)">
+              <Formula id="0f8229a8-9563-4ab5-bea2-47ac8e17dff1" name="PARAM_logD_Factor_RBC" formula="K1+ (K2 +K3 +K4)* base ^ 1 + K5* base ^ max(CT0+CT1;-CT0-CT1) +K6* base ^ max(CT0+CT2;-CT0-CT2) +K7* base ^ max(CT2+CT1;-CT2-CT1) +K8* base ^ max(CT0+CT1+CT2;-CT0-CT1-CT2)">
                 <Paths>
                   <Path path="72" as="38" />
                   <Path path="39" as="40" />
@@ -2551,7 +2685,7 @@
                   <Path path="59" as="60" />
                 </Paths>
               </Formula>
-              <Formula id="92f15277-a512-414d-968a-70722b647dfb" name="PARAM_K_a_PL_rbc" formula="K_n_PL*K_a_PL_pH_Factor">
+              <Formula id="aacaa849-2087-4338-93ec-669d46f929a0" name="PARAM_K_a_PL_rbc" formula="K_n_PL*K_a_PL_pH_Factor">
                 <Paths>
                   <Path path="73" as="74" />
                   <Path path="10" as="11" />
@@ -2561,17 +2695,17 @@
                   <Path path="70" as="71" />
                 </Paths>
               </Formula>
-              <Formula id="4ed0c9f9-411e-4a9b-89ae-e42f4afdfcca" name="PARAM_K_n_L_rbc" formula="10^LogD">
+              <Formula id="aa179bd1-6517-4150-85c2-beac6522c9fa" name="PARAM_K_n_L_rbc" formula="10^LogD">
                 <Paths>
                   <Path path="75" as="76" dim="5" />
                 </Paths>
               </Formula>
-              <Formula id="023d251b-fe58-4444-b380-11e0eb3436c1" name="PARAM_K_n_PL_rbc" formula="10^LogMA">
+              <Formula id="cd184357-084b-49e1-b953-f9da0b764604" name="PARAM_K_n_PL_rbc" formula="10^LogMA">
                 <Paths>
                   <Path path="3" as="4" dim="5" />
                 </Paths>
               </Formula>
-              <Formula id="15205f86-9b7a-41ae-a51a-44e06080e97e" name="PARAM_pKa_pH_WS_bc_F1" formula="CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1">
+              <Formula id="5e3b3fca-67b2-4857-bfb0-e6dfedfdc91e" name="PARAM_pKa_pH_WS_bc_F1" formula="CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1">
                 <Paths>
                   <Path path="39" as="40" />
                   <Path path="77" as="78" />
@@ -2579,7 +2713,7 @@
                   <Path path="70" as="80" />
                 </Paths>
               </Formula>
-              <Formula id="48be4450-ff13-4174-8e92-7a3d3cd11ed7" name="PARAM_pKa_pH_WS_bc_F2" formula="CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1">
+              <Formula id="c5f01c3b-9e2b-490b-ab39-45a158d4d092" name="PARAM_pKa_pH_WS_bc_F2" formula="CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1">
                 <Paths>
                   <Path path="41" as="42" />
                   <Path path="77" as="78" />
@@ -2587,7 +2721,7 @@
                   <Path path="70" as="80" />
                 </Paths>
               </Formula>
-              <Formula id="b60a8c6e-b2cb-44f5-afcb-79fd9343818b" name="PARAM_pKa_pH_WS_bc_F3" formula="CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1">
+              <Formula id="938d6f06-5884-4338-bfd9-f47eb4149f3f" name="PARAM_pKa_pH_WS_bc_F3" formula="CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1">
                 <Paths>
                   <Path path="43" as="44" />
                   <Path path="77" as="78" />
@@ -2595,63 +2729,63 @@
                   <Path path="70" as="80" />
                 </Paths>
               </Formula>
-              <Formula id="3526233d-9276-490b-856d-6c2f70030466" name="PARAM_pKa_pH_WS_bc_K1" formula="F1*F2*F3">
+              <Formula id="f7ed0c96-b3e3-489b-a00d-636ba87e09f5" name="PARAM_pKa_pH_WS_bc_K1" formula="F1*F2*F3">
                 <Paths>
                   <Path path="83" as="84" />
                   <Path path="85" as="86" />
                   <Path path="87" as="88" />
                 </Paths>
               </Formula>
-              <Formula id="277c0496-6123-4ad6-9f0a-8de2479f4d5f" name="PARAM_pKa_pH_WS_bc_K2" formula="(1-F1)*F2*F3">
+              <Formula id="f42f726f-ba14-4790-823a-2116046f4a68" name="PARAM_pKa_pH_WS_bc_K2" formula="(1-F1)*F2*F3">
                 <Paths>
                   <Path path="83" as="84" />
                   <Path path="85" as="86" />
                   <Path path="87" as="88" />
                 </Paths>
               </Formula>
-              <Formula id="d9679b76-20d5-472f-a04a-4fd046199dad" name="PARAM_pKa_pH_WS_bc_K3" formula="F1*(1-F2)*F3">
+              <Formula id="64f5be83-4f00-44ec-811d-09abcae7e392" name="PARAM_pKa_pH_WS_bc_K3" formula="F1*(1-F2)*F3">
                 <Paths>
                   <Path path="83" as="84" />
                   <Path path="85" as="86" />
                   <Path path="87" as="88" />
                 </Paths>
               </Formula>
-              <Formula id="1df6f3a4-567b-4ffc-8d1f-0102187611cc" name="PARAM_pKa_pH_WS_bc_K4" formula="F1*F2*(1-F3)">
+              <Formula id="b34610f6-0474-4f2d-b39a-4e23bed31a5c" name="PARAM_pKa_pH_WS_bc_K4" formula="F1*F2*(1-F3)">
                 <Paths>
                   <Path path="83" as="84" />
                   <Path path="85" as="86" />
                   <Path path="87" as="88" />
                 </Paths>
               </Formula>
-              <Formula id="f747c578-f53b-46f1-aa62-27a56ac5b428" name="PARAM_pKa_pH_WS_bc_K5" formula="(1-F1)*(1-F2)*F3">
+              <Formula id="4a729114-ddd4-47d3-8bcb-ee243b09dba3" name="PARAM_pKa_pH_WS_bc_K5" formula="(1-F1)*(1-F2)*F3">
                 <Paths>
                   <Path path="83" as="84" />
                   <Path path="85" as="86" />
                   <Path path="87" as="88" />
                 </Paths>
               </Formula>
-              <Formula id="48c54548-81f1-4752-a534-58170836afbe" name="PARAM_pKa_pH_WS_bc_K6" formula="(1-F1)*F2*(1-F3)">
+              <Formula id="efccce7e-76f6-4df9-a404-cdd04d293ac2" name="PARAM_pKa_pH_WS_bc_K6" formula="(1-F1)*F2*(1-F3)">
                 <Paths>
                   <Path path="83" as="84" />
                   <Path path="85" as="86" />
                   <Path path="87" as="88" />
                 </Paths>
               </Formula>
-              <Formula id="f081ca63-403a-43cd-896f-f3a659eddaae" name="PARAM_pKa_pH_WS_bc_K7" formula="F1*(1-F2)*(1-F3)">
+              <Formula id="e050215e-0441-44ce-b980-a353fe15906c" name="PARAM_pKa_pH_WS_bc_K7" formula="F1*(1-F2)*(1-F3)">
                 <Paths>
                   <Path path="83" as="84" />
                   <Path path="85" as="86" />
                   <Path path="87" as="88" />
                 </Paths>
               </Formula>
-              <Formula id="655d1cab-d38c-48f6-a7f6-723501377e5a" name="PARAM_pKa_pH_WS_bc_K8" formula="(1-F1)*(1-F2)*(1-F3)">
+              <Formula id="5ff3131f-5fad-4ec1-8227-ba1424d3d085" name="PARAM_pKa_pH_WS_bc_K8" formula="(1-F1)*(1-F2)*(1-F3)">
                 <Paths>
                   <Path path="83" as="84" />
                   <Path path="85" as="86" />
                   <Path path="87" as="88" />
                 </Paths>
               </Formula>
-              <Formula id="0f50393c-3b00-473a-af85-ff42cf08cdb4" name="PARAM_K_a_PL_pH_Factor" formula="K1+ K2* base ^ CT0 + K3* base ^ CT1+K4 *base^CT2 + K5* base ^ (CT0+CT1) +K6* base ^ (CT0+CT2) +K7* base ^ (CT2+CT1) +K8* base ^ (CT0+CT1+CT2)">
+              <Formula id="9f6d6817-94c0-4ebf-94d2-6f793f2ea959" name="PARAM_K_a_PL_pH_Factor" formula="K1+ K2* base ^ CT0 + K3* base ^ CT1+K4 *base^CT2 + K5* base ^ (CT0+CT1) +K6* base ^ (CT0+CT2) +K7* base ^ (CT2+CT1) +K8* base ^ (CT0+CT1+CT2)">
                 <Paths>
                   <Path path="89" as="46" />
                   <Path path="90" as="48" />
@@ -2667,7 +2801,7 @@
                   <Path path="100" as="44" />
                 </Paths>
               </Formula>
-              <Formula id="e67dee69-78d6-48de-ad33-02eef3ec8a32" name="PARAM_LogD" dim="Log Units" formula="LogP+Log10(logD_Factor)">
+              <Formula id="c307e3a5-424a-4630-86f4-5b780c2d0cbc" name="PARAM_LogD" dim="Log Units" formula="LogP+Log10(logD_Factor)">
                 <Paths>
                   <Path path="61" as="62" />
                   <Path path="3" as="63" dim="5" />
@@ -2677,7 +2811,7 @@
                   <Path path="101" as="102" />
                 </Paths>
               </Formula>
-              <Formula id="00871bf9-456c-410d-a111-865c7961c329" name="PARAM_logD_Factor" formula="K1+ (K2 +K3 +K4)* base ^ 1 + K5* base ^ max(CT0+CT1;-CT0-CT1) +K6* base ^ max(CT0+CT2;-CT0-CT2) +K7* base ^ max(CT2+CT1;-CT2-CT1) +K8* base ^ max(CT0+CT1+CT2;-CT0-CT1-CT2)">
+              <Formula id="fe02aad1-24f2-4581-bb1d-43269f0acb55" name="PARAM_logD_Factor" formula="K1+ (K2 +K3 +K4)* base ^ 1 + K5* base ^ max(CT0+CT1;-CT0-CT1) +K6* base ^ max(CT0+CT2;-CT0-CT2) +K7* base ^ max(CT2+CT1;-CT2-CT1) +K8* base ^ max(CT0+CT1+CT2;-CT0-CT1-CT2)">
                 <Paths>
                   <Path path="89" as="46" />
                   <Path path="90" as="48" />
@@ -2693,7 +2827,7 @@
                   <Path path="100" as="44" />
                 </Paths>
               </Formula>
-              <Formula id="b44d693f-71a1-4a96-a781-451b5a8eec44" name="PARAM_K_a_PL" formula="K_n_PL*K_a_PL_pH_Factor">
+              <Formula id="16461ccd-246b-4c80-b2ce-12b44b3f9ac6" name="PARAM_K_a_PL" formula="K_n_PL*K_a_PL_pH_Factor">
                 <Paths>
                   <Path path="73" as="74" />
                   <Path path="26" as="11" />
@@ -2703,17 +2837,17 @@
                   <Path path="101" as="102" />
                 </Paths>
               </Formula>
-              <Formula id="6be389da-44f6-4d7e-8d69-50c89e1ba657" name="PARAM_K_n_L" formula="10^LogD">
+              <Formula id="950229dc-4610-4950-ae40-0a5c199f0c9a" name="PARAM_K_n_L" formula="10^LogD">
                 <Paths>
                   <Path path="104" as="76" dim="5" />
                 </Paths>
               </Formula>
-              <Formula id="081198ea-e7b9-4e5a-b77c-0f9bc96adba1" name="PARAM_K_n_PL" formula="10^LogMA">
+              <Formula id="77d7dd5e-5b02-400f-9ca8-d8fef00a780e" name="PARAM_K_n_PL" formula="10^LogMA">
                 <Paths>
                   <Path path="3" as="4" dim="5" />
                 </Paths>
               </Formula>
-              <Formula id="6ae5d58f-439d-4c62-b240-a1b3a42308f5" name="PARAM_pKa_pH_WS_cell_F1" formula="CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1">
+              <Formula id="da41157c-9f5c-48de-a487-3fe84a8183b3" name="PARAM_pKa_pH_WS_cell_F1" formula="CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1">
                 <Paths>
                   <Path path="105" as="80" />
                   <Path path="98" as="40" />
@@ -2721,7 +2855,7 @@
                   <Path path="64" as="65" />
                 </Paths>
               </Formula>
-              <Formula id="9f22607b-a921-417e-85c4-d5853e412242" name="PARAM_pKa_pH_WS_cell_F2" formula="CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1">
+              <Formula id="885986a9-c19d-4eff-9cba-65868b5ebb43" name="PARAM_pKa_pH_WS_cell_F2" formula="CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1">
                 <Paths>
                   <Path path="105" as="80" />
                   <Path path="99" as="42" />
@@ -2729,7 +2863,7 @@
                   <Path path="66" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="08b29b0f-dd96-479a-9a90-6a63596f89de" name="PARAM_pKa_pH_WS_cell_F3" formula="CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1">
+              <Formula id="8530c480-02ea-4762-aee1-06315e1c0a09" name="PARAM_pKa_pH_WS_cell_F3" formula="CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1">
                 <Paths>
                   <Path path="105" as="80" />
                   <Path path="100" as="44" />
@@ -2737,56 +2871,56 @@
                   <Path path="68" as="69" />
                 </Paths>
               </Formula>
-              <Formula id="f72093fe-15ad-464d-bb2f-d305f6f76003" name="PARAM_pKa_pH_WS_cell_K1" formula="F1*F2*F3">
+              <Formula id="4f8efbe5-9713-4c06-8b2c-7289ff55c5a8" name="PARAM_pKa_pH_WS_cell_K1" formula="F1*F2*F3">
                 <Paths>
                   <Path path="107" as="84" />
                   <Path path="108" as="86" />
                   <Path path="109" as="88" />
                 </Paths>
               </Formula>
-              <Formula id="dde7f7ec-c7ac-4b52-b990-772601c9f04e" name="PARAM_pKa_pH_WS_cell_K2" formula="(1-F1)*F2*F3">
+              <Formula id="d553c7f8-8bdb-45cd-8dfe-a477954f23ad" name="PARAM_pKa_pH_WS_cell_K2" formula="(1-F1)*F2*F3">
                 <Paths>
                   <Path path="107" as="84" />
                   <Path path="108" as="86" />
                   <Path path="109" as="88" />
                 </Paths>
               </Formula>
-              <Formula id="125950ca-0be3-4766-9aa6-02255d9035fb" name="PARAM_pKa_pH_WS_cell_K3" formula="F1*(1-F2)*F3">
+              <Formula id="155ca4c6-49f6-4f15-a166-93118573438c" name="PARAM_pKa_pH_WS_cell_K3" formula="F1*(1-F2)*F3">
                 <Paths>
                   <Path path="107" as="84" />
                   <Path path="108" as="86" />
                   <Path path="109" as="88" />
                 </Paths>
               </Formula>
-              <Formula id="697e3357-6e6e-49b3-a10b-3d1e27566675" name="PARAM_pKa_pH_WS_cell_K4" formula="F1*F2*(1-F3)">
+              <Formula id="fe0a3fed-aa01-44e8-807d-7fde4b014ea1" name="PARAM_pKa_pH_WS_cell_K4" formula="F1*F2*(1-F3)">
                 <Paths>
                   <Path path="107" as="84" />
                   <Path path="108" as="86" />
                   <Path path="109" as="88" />
                 </Paths>
               </Formula>
-              <Formula id="3b4ef14a-49b9-4bbe-b8e4-e153cb4a3da0" name="PARAM_pKa_pH_WS_cell_K5" formula="(1-F1)*(1-F2)*F3">
+              <Formula id="6ed05fce-b913-44e5-90ea-5303f6892de2" name="PARAM_pKa_pH_WS_cell_K5" formula="(1-F1)*(1-F2)*F3">
                 <Paths>
                   <Path path="107" as="84" />
                   <Path path="108" as="86" />
                   <Path path="109" as="88" />
                 </Paths>
               </Formula>
-              <Formula id="950f061f-63a8-4370-a11d-591a138719fd" name="PARAM_pKa_pH_WS_cell_K6" formula="(1-F1)*F2*(1-F3)">
+              <Formula id="d1b97a01-9d66-42cb-8c10-921b1bc83fc1" name="PARAM_pKa_pH_WS_cell_K6" formula="(1-F1)*F2*(1-F3)">
                 <Paths>
                   <Path path="107" as="84" />
                   <Path path="108" as="86" />
                   <Path path="109" as="88" />
                 </Paths>
               </Formula>
-              <Formula id="ce03ad92-9150-4d21-b042-684d26f813bc" name="PARAM_pKa_pH_WS_cell_K7" formula="F1*(1-F2)*(1-F3)">
+              <Formula id="7a79d0af-3bd9-458d-82aa-30cbc0009b1d" name="PARAM_pKa_pH_WS_cell_K7" formula="F1*(1-F2)*(1-F3)">
                 <Paths>
                   <Path path="107" as="84" />
                   <Path path="108" as="86" />
                   <Path path="109" as="88" />
                 </Paths>
               </Formula>
-              <Formula id="254f6c41-edbc-4f03-8730-82a56725f64e" name="PARAM_pKa_pH_WS_cell_K8" formula="(1-F1)*(1-F2)*(1-F3)">
+              <Formula id="abcd315b-8e09-4058-a618-81495ffcfea1" name="PARAM_pKa_pH_WS_cell_K8" formula="(1-F1)*(1-F2)*(1-F3)">
                 <Paths>
                   <Path path="107" as="84" />
                   <Path path="108" as="86" />
@@ -2908,10 +3042,11 @@
             </StringMap>
           </FormulaCache>
         </CoreCalculationMethod>
-        <CoreCalculationMethod id="6b074b2c-f030-4016-ae3f-79a91665ea24" name="Cellular permeability - PK-Sim Standard" icon="CoreCalculationMethod" bbVersion="0" category="DiffusionIntCell">
+        <CoreCalculationMethod id="cfffa244-2f26-4509-8daf-79dfdf535b11" name="Cellular permeability - PK-Sim Standard" icon="CoreCalculationMethod" bbVersion="0" category="DiffusionIntCell">
+          <Creation createdAt="5248846165144629088" createdBy="Michael" creationMode="New" origin="Other" />
           <OutputFormulas>
             <KeyValue>
-              <ConstantFormula id="7e35b307-d9f3-469f-bbe5-7e0dd55079d1" value="1" />
+              <ConstantFormula id="97fb9a05-8bab-4c42-bef0-f987c870b5dc" value="1" />
               <ParameterDescriptor parameterName="P_bc_pls_factor">
                 <ContainerCriteria>
                   <DescriptorConditions>
@@ -2921,7 +3056,7 @@
               </ParameterDescriptor>
             </KeyValue>
             <KeyValue>
-              <ConstantFormula id="d9491c26-e306-4fd9-a1ed-3260b2621cc8" value="1" />
+              <ConstantFormula id="25926e88-be72-47c3-a98b-2a0baf4b6e3b" value="1" />
               <ParameterDescriptor parameterName="P_pls_bc_factor">
                 <ContainerCriteria>
                   <DescriptorConditions>
@@ -2931,7 +3066,7 @@
               </ParameterDescriptor>
             </KeyValue>
             <KeyValue>
-              <ConstantFormula id="f67e5e9d-6b05-4535-88c3-b6e17e409c36" value="1" />
+              <ConstantFormula id="41fbc843-3b56-453a-b909-2b34b9e03020" value="1" />
               <ParameterDescriptor parameterName="P_cell_int_factor">
                 <ContainerCriteria>
                   <DescriptorConditions>
@@ -2941,7 +3076,7 @@
               </ParameterDescriptor>
             </KeyValue>
             <KeyValue>
-              <ConstantFormula id="03be01bf-a5ea-421e-b4d1-84405cc7b798" value="1" />
+              <ConstantFormula id="104e6bd0-c03f-4276-8f0c-54bebfc433a6" value="1" />
               <ParameterDescriptor parameterName="P_int_cell_factor">
                 <ContainerCriteria>
                   <DescriptorConditions>
@@ -2952,14 +3087,12 @@
             </KeyValue>
           </OutputFormulas>
           <HelpParameters />
-          <FormulaCache>
-            <StringMap />
-          </FormulaCache>
         </CoreCalculationMethod>
-        <CoreCalculationMethod id="6971ffaf-77e7-4c55-992e-20d33211f6b2" name="Cellular permeability - Charge dependent Schmitt" icon="CoreCalculationMethod" bbVersion="0" category="DiffusionIntCell">
+        <CoreCalculationMethod id="15e8781b-e22f-4e2e-af93-839e42be5890" name="Cellular permeability - Charge dependent Schmitt" icon="CoreCalculationMethod" bbVersion="0" category="DiffusionIntCell">
+          <Creation createdAt="5248846165144629088" createdBy="Michael" creationMode="New" origin="Other" />
           <OutputFormulas>
             <KeyValue>
-              <Formula id="1ae3dd7d-045f-4518-974f-bcd22c2a4ff3" name="PARAM_P_rbc_pls_factor_WS" formula="K1+ (K2 +K3 +K4)* base ^ 1 + K5* base ^ max(CT0+CT1;-CT0-CT1) +K6* base ^ max(CT0+CT2;-CT0-CT2) +K7* base ^ max(CT2+CT1;-CT2-CT1) +K8* base ^ max(CT0+CT1+CT2;-CT0-CT1-CT2)">
+              <Formula id="67daadd0-0d87-46ac-9b55-cc7cfe96008f" name="PARAM_P_rbc_pls_factor_WS" formula="K1+ (K2 +K3 +K4)* base ^ 1 + K5* base ^ max(CT0+CT1;-CT0-CT1) +K6* base ^ max(CT0+CT2;-CT0-CT2) +K7* base ^ max(CT2+CT1;-CT2-CT1) +K8* base ^ max(CT0+CT1+CT2;-CT0-CT1-CT2)">
                 <Paths>
                   <Path path="0" as="1" />
                   <Path path="2" as="3" />
@@ -2984,7 +3117,7 @@
               </ParameterDescriptor>
             </KeyValue>
             <KeyValue>
-              <Formula id="0b5f26c6-f141-4430-998a-0760b2b837d6" name="PARAM_P_pls_rbc_factor_WS" formula="K1+ (K2 +K3 +K4)* base ^ 1 + K5* base ^ max(CT0+CT1;-CT0-CT1) +K6* base ^ max(CT0+CT2;-CT0-CT2) +K7* base ^ max(CT2+CT1;-CT2-CT1) +K8* base ^ max(CT0+CT1+CT2;-CT0-CT1-CT2)">
+              <Formula id="3346cc50-d9c0-4aae-b597-2ad70a064520" name="PARAM_P_pls_rbc_factor_WS" formula="K1+ (K2 +K3 +K4)* base ^ 1 + K5* base ^ max(CT0+CT1;-CT0-CT1) +K6* base ^ max(CT0+CT2;-CT0-CT2) +K7* base ^ max(CT2+CT1;-CT2-CT1) +K8* base ^ max(CT0+CT1+CT2;-CT0-CT1-CT2)">
                 <Paths>
                   <Path path="0" as="1" />
                   <Path path="2" as="3" />
@@ -3009,7 +3142,7 @@
               </ParameterDescriptor>
             </KeyValue>
             <KeyValue>
-              <Formula id="52d4c7ad-ce32-45b2-82e5-7f4b960c5676" name="PARAM_P_cell_int_factor_WS" formula="K1+ (K2 +K3 +K4)* base ^ 1 + K5* base ^ max(CT0+CT1;-CT0-CT1) +K6* base ^ max(CT0+CT2;-CT0-CT2) +K7* base ^ max(CT2+CT1;-CT2-CT1) +K8* base ^ max(CT0+CT1+CT2;-CT0-CT1-CT2)">
+              <Formula id="7df9bbe3-c2ab-4f80-829f-6a49f269baaa" name="PARAM_P_cell_int_factor_WS" formula="K1+ (K2 +K3 +K4)* base ^ 1 + K5* base ^ max(CT0+CT1;-CT0-CT1) +K6* base ^ max(CT0+CT2;-CT0-CT2) +K7* base ^ max(CT2+CT1;-CT2-CT1) +K8* base ^ max(CT0+CT1+CT2;-CT0-CT1-CT2)">
                 <Paths>
                   <Path path="32" as="9" />
                   <Path path="33" as="11" />
@@ -3034,7 +3167,7 @@
               </ParameterDescriptor>
             </KeyValue>
             <KeyValue>
-              <Formula id="cc5461a0-d2e9-438b-86c1-75449b334fdb" name="PARAM_P_int_cell_factor_WS" formula="K1+ (K2 +K3 +K4)* base ^ 1 + K5* base ^ max(CT0+CT1;-CT0-CT1) +K6* base ^ max(CT0+CT2;-CT0-CT2) +K7* base ^ max(CT2+CT1;-CT2-CT1) +K8* base ^ max(CT0+CT1+CT2;-CT0-CT1-CT2)">
+              <Formula id="a84b7f4b-dd62-4749-b003-2a52120ba88a" name="PARAM_P_int_cell_factor_WS" formula="K1+ (K2 +K3 +K4)* base ^ 1 + K5* base ^ max(CT0+CT1;-CT0-CT1) +K6* base ^ max(CT0+CT2;-CT0-CT2) +K7* base ^ max(CT2+CT1;-CT2-CT1) +K8* base ^ max(CT0+CT1+CT2;-CT0-CT1-CT2)">
                 <Paths>
                   <Path path="44" as="9" />
                   <Path path="45" as="11" />
@@ -3061,8 +3194,9 @@
           </OutputFormulas>
           <HelpParameters>
             <KeyValue>
-              <Parameter id="dff20652-ae53-410f-b203-117a7c67c252" name="pKa_pH_WS_bc_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="0e130ebc-072d-4736-9817-a222d26a6a17">
+              <Parameter id="e7b12aac-d6dc-4d36-aa8c-509dcbd66f69" name="pKa_pH_WS_bc_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="9bdb9bbb-412b-4799-83dd-0d6726ac8d58">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -3071,8 +3205,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="968f2713-306d-430b-b309-e99ab91f0d0d" name="pKa_pH_WS_bc_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="14adf8a8-619d-4dfc-861a-bd0144cfa834">
+              <Parameter id="9177614a-810b-4a12-bbf3-418ad17440c0" name="pKa_pH_WS_bc_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="c68f7291-e992-4277-b7cb-8bb2c57cd0ce">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -3081,8 +3216,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="e2087a30-a575-477b-901d-249cc2478b28" name="pKa_pH_WS_bc_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="7b6d36f2-46c0-4af7-8a7f-6cdc6403cefb">
+              <Parameter id="dabe9c34-ac2d-4a95-80a3-5c4b497cb1cc" name="pKa_pH_WS_bc_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="90b003ac-b0a5-4400-8d0a-0b4c706913ae">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -3091,8 +3227,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="8f1856ce-fb9d-42fa-950b-fb701d1bbce8" name="pKa_pH_WS_bc_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="43282724-ac4c-4c23-bab0-1162e3fd6076">
+              <Parameter id="5caaa3ec-7b9d-42a6-aa7c-978a20c77731" name="pKa_pH_WS_bc_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="3a77518a-b24d-466e-9543-e00b431ce2be">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -3101,8 +3238,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="11f3e5f6-f084-4bc8-af45-bdb00f306a67" name="pKa_pH_WS_bc_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="a170792b-b510-4cda-b447-90eadd06286d">
+              <Parameter id="bcb464ac-5de4-41e7-b798-3759ecadb467" name="pKa_pH_WS_bc_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="b11fb6e6-d041-4b05-9829-17e30c0467e1">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -3111,8 +3249,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="68175606-3ad2-4aec-81b4-350e504b2a36" name="pKa_pH_WS_bc_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="78507cf8-27a8-4904-bb9b-10a91f0c97d0">
+              <Parameter id="6b870c58-fe2d-4f3c-a743-b6044251a14e" name="pKa_pH_WS_bc_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="dafad48d-f6ec-41ba-808b-5a980b88e17a">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -3121,8 +3260,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="3e7aa7b2-2457-4d28-9db6-ed03ede4a761" name="pKa_pH_WS_bc_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="34847dc2-3ca2-4944-a0a4-4d98501f33a6">
+              <Parameter id="65e468b8-6415-444c-a5db-067d44cf9fc4" name="pKa_pH_WS_bc_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="f227dc95-c36e-49e9-9dd6-9d14790c19b9">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -3131,8 +3271,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="85e04023-b8fe-4617-a930-d0d0252f3751" name="pKa_pH_WS_bc_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="e5336433-62c2-41a8-a7d4-74877d6d175e">
+              <Parameter id="d2095834-9ad3-4a4e-add3-d12a2e7bacd2" name="pKa_pH_WS_bc_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="8f850fc1-b285-4adc-b60b-145b9871f6a4">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -3141,8 +3282,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="5538b7de-c1da-40a0-83f5-c452ea881a48" name="pKa_pH_WS_bc_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="cd30cc62-a4ed-414c-9dbd-40771e2165f3">
+              <Parameter id="09959981-c467-49aa-8ef9-8d83a5c1fd5a" name="pKa_pH_WS_bc_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="54dc6148-2211-43f1-8e9c-03f4153e95b6">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -3151,8 +3293,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="2d1563de-9c2c-41cf-9dec-4a35d2e85742" name="pKa_pH_WS_bc_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="c202fda3-183a-4e79-ada4-1ff475e32f0a">
+              <Parameter id="baddb4ac-98fd-4ecb-b91e-4be40aed8401" name="pKa_pH_WS_bc_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="b6d2de95-bdd0-42cd-96a5-f0fc54d9d658">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -3161,8 +3304,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="5739e399-2e72-4c92-bc33-ff5828e690c6" name="pKa_pH_WS_bc_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="bbdac73f-8231-4b71-9861-e12e7d4578ba">
+              <Parameter id="e9692365-9f7c-44c0-9567-ed0fcec219d5" name="pKa_pH_WS_bc_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ecaa2a36-c9cd-4daa-9b38-81adfd4cc9e4">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -3171,8 +3315,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="05745e0f-f56b-43bc-9d38-537d422638a9" name="pKa_pH_WS_pls_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="f9d086e0-e20f-4af4-9477-9588aefd1b76">
+              <Parameter id="7988ea81-31e0-478e-ad27-f9ddf83d9b32" name="pKa_pH_WS_pls_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="e2441d79-d13e-4c76-bf4f-7c378eb2932b">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -3181,8 +3326,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="2e49f4b5-25f1-46ae-b93e-35148afd6055" name="pKa_pH_WS_pls_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="ee466d55-b3de-4654-98c7-26ad1e30a53c">
+              <Parameter id="f5e1677a-933a-470a-8caf-457b26883294" name="pKa_pH_WS_pls_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="cf268419-0ae0-4e5e-b82d-6d18285f5db5">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -3191,8 +3337,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="41611ab3-400e-4d2b-9401-6aeeec2db69e" name="pKa_pH_WS_pls_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="c52757b9-5e06-4ee3-b8b3-c8eda65e09e9">
+              <Parameter id="1099fbfc-a852-4416-bf78-e281f971221f" name="pKa_pH_WS_pls_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="61403ca7-32fe-44d1-83c6-861d152a7704">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -3201,8 +3348,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="52083189-2188-4f8d-bc38-242d356eb06f" name="pKa_pH_WS_pls_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="41436d31-3f09-4260-8bb2-3af6c6612238">
+              <Parameter id="5243d388-bc2b-4377-9453-7155305782cc" name="pKa_pH_WS_pls_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="41cb6658-9221-431f-95f1-079a5e85368f">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -3211,8 +3359,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="19cf57ea-dab6-47f9-a280-56479987346b" name="pKa_pH_WS_pls_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="34d258d8-9147-4544-8584-b0f0e9806c34">
+              <Parameter id="b3dbf30c-d6b9-433c-ab00-032ab8546a1d" name="pKa_pH_WS_pls_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="3fa4194a-1832-424d-8a62-b43ec8555bf6">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -3221,8 +3370,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="264ccaca-6b2c-4c9b-b50b-19203b6fcc1d" name="pKa_pH_WS_pls_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="acd00a49-8a79-41f7-bd98-159fe90a9d08">
+              <Parameter id="5d8c1145-165a-42a5-870c-4329e6965dbe" name="pKa_pH_WS_pls_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="9dcd8cbd-7d4d-470d-8ac1-283498665d4d">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -3231,8 +3381,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="f0d5981c-1844-4b98-9f4b-528f56cf1649" name="pKa_pH_WS_pls_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="94b3ad28-5ab4-4a69-8817-9c398ed6efcf">
+              <Parameter id="0666aabb-ef55-4a1d-8662-83dac28ecbe8" name="pKa_pH_WS_pls_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="787594e8-6378-4ebb-9ae8-9541898653b3">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -3241,8 +3392,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="245756fe-1f28-4663-abb1-2c2e684010e2" name="pKa_pH_WS_pls_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="4a4e44c6-d611-4449-ba1b-8249030df23e">
+              <Parameter id="0978dd88-56da-4e4e-9229-1c4dd0cd9fb0" name="pKa_pH_WS_pls_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="0ebf9ffc-c360-4c89-990a-c4ca70014415">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -3251,8 +3403,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="87684384-fbdc-433b-aff0-bc7e5df0a6b1" name="pKa_pH_WS_pls_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="a305ef8f-488b-4d7d-87a7-56793045ae9d">
+              <Parameter id="03dd4d5e-c482-44ea-96a9-d3e79593f260" name="pKa_pH_WS_pls_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="701dffed-ea2d-4f7d-b5bc-f577f549cd2c">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -3261,8 +3414,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="ce0e80e9-965e-4620-82fd-e327fca39ecc" name="pKa_pH_WS_pls_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="4bf0dba1-7857-45f8-bd8f-32835d9d2b90">
+              <Parameter id="4fa9f779-f87d-456c-8ed1-ae1abb2a2b30" name="pKa_pH_WS_pls_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ce0b2f4b-a7ec-4c08-8049-c87630202557">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -3271,8 +3425,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="effdc654-00e8-44f6-bb1c-c0195e3d7c44" name="pKa_pH_WS_pls_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="5f4c5f8d-f931-4be3-9885-df4fc85c1b7d">
+              <Parameter id="aa5c696e-595d-48fb-b3a1-fd582ee447db" name="pKa_pH_WS_pls_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="87cdd92a-241b-438f-bfb8-845f34ecb530">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -3281,8 +3436,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="22f26118-3825-40c1-bf84-5dbaa830233d" name="pKa_pH_WS_cell_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="27e8333b-2089-417f-97da-1a958f4431ef">
+              <Parameter id="06c9f792-3bc4-4f9b-880a-88b76003a060" name="pKa_pH_WS_cell_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="9487ef9f-17c3-4d85-98d0-df51320e626c">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -3291,8 +3447,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="22335840-65e1-479a-bc0d-bad27341737e" name="pKa_pH_WS_cell_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="a4fcaa3b-5acd-4b84-bd80-a728cb32b78d">
+              <Parameter id="905b776a-7ff9-4d08-a1d1-5675fd539254" name="pKa_pH_WS_cell_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="696e3da0-57ce-484e-8f1a-b7771818e2a3">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -3301,8 +3458,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="b1120e14-06c5-445b-8fda-b0490501d131" name="pKa_pH_WS_cell_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="40446be7-cc1e-493c-8daa-b4293358019c">
+              <Parameter id="4b9f6156-03b4-47ed-af0a-4138e50c198b" name="pKa_pH_WS_cell_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="fbdb9c9b-0b04-46f7-8d14-ef6c610aca23">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -3311,8 +3469,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="abcbbc4a-37c8-4022-9622-c47b02a8ef89" name="pKa_pH_WS_cell_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="c341fe71-b034-4284-9e00-3ce8df8caa27">
+              <Parameter id="e95c5197-56bb-4732-b190-824718939d9b" name="pKa_pH_WS_cell_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="12659bf7-4c70-4f47-841d-f15e16056464">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -3321,8 +3480,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="6b0dd5ee-51b4-4ccd-8573-73af62375134" name="pKa_pH_WS_cell_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="3ec0debb-ac66-4fbf-b6c6-daeccb1fd906">
+              <Parameter id="387fcd5a-ff3a-4fc6-9d8d-569001d3ccc8" name="pKa_pH_WS_cell_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="13606054-f010-4ea7-b6e8-aa936882446d">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -3331,8 +3491,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="10a8996b-c197-429a-8808-60c599a48998" name="pKa_pH_WS_cell_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="347aa6b5-30fd-4e71-a831-6971ef33d6e7">
+              <Parameter id="2956e5db-7480-4a2d-b0eb-e35f4287f36f" name="pKa_pH_WS_cell_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="d0000349-f6cc-4709-9985-1c52181f87c0">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -3341,8 +3502,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="2d518154-4d6b-4899-a2fb-edbf672139b8" name="pKa_pH_WS_cell_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="9b0de2a5-7c14-474d-8fa9-2bf3a0da3cee">
+              <Parameter id="387decb2-f516-4757-bc91-1fe4adac6737" name="pKa_pH_WS_cell_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="0c755d27-59c3-499f-90ca-efef1f01acb0">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -3351,8 +3513,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="f536c210-256e-4eb5-bcec-2cd925ca9dc3" name="pKa_pH_WS_cell_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="72f39ed2-889f-4be0-9da9-73c66bd8e795">
+              <Parameter id="5496ed17-ccdd-4c61-9c07-a6f0c4852721" name="pKa_pH_WS_cell_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="d26f5e2d-cedb-4a13-88e4-bbc6a4a0d1e2">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -3361,8 +3524,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="9e072811-0257-4ebf-93be-318affe53c32" name="pKa_pH_WS_cell_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="0fdbd9b8-46e2-4aaa-afa8-ff564f22b7fe">
+              <Parameter id="bad142f2-6d2c-4307-a906-2419ab1f4603" name="pKa_pH_WS_cell_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="23ec8c29-0b09-4f7e-8296-71c3c7dd5e6c">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -3371,8 +3535,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="a4c6cf90-bb0a-4f1e-8982-eb56e81c615b" name="pKa_pH_WS_cell_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="71ba8505-4cb7-461e-8402-2df8d8368e7c">
+              <Parameter id="9cd24125-f3a0-438f-a262-d4b8bf80510c" name="pKa_pH_WS_cell_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="4794dbf6-9283-45d1-a8d5-f17574b43b4c">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -3381,8 +3546,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="a8a80305-4699-4bb8-b1b6-68d5f262c072" name="pKa_pH_WS_cell_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="0bbf2818-0ce1-4485-90cb-cda028de5a81">
+              <Parameter id="41be5bfc-73df-4714-b0ae-d88a7aef392f" name="pKa_pH_WS_cell_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="48cfaeb9-8e0b-4ba0-90f1-12df95ea50ec">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -3391,8 +3557,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="83bcb632-cd97-4cc4-bd2d-bb61d886a5bd" name="pKa_pH_WS_int_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="f43d7bab-cb68-4262-b0c1-e5822d4e1fe9">
+              <Parameter id="bf24527a-239f-44ec-815a-3d5318283ad3" name="pKa_pH_WS_int_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="3c116ae9-2dc2-4440-a7bb-1421ea929e97">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -3401,8 +3568,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="a35310f3-a871-43cb-8bea-101689ea9cc9" name="pKa_pH_WS_int_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="05e82657-cdaf-45cf-83f2-a3712757b54e">
+              <Parameter id="15dd00b3-d498-4846-bc29-e85c745b4d3a" name="pKa_pH_WS_int_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="449b0d65-d7b7-4dca-839a-9a59262f7a69">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -3411,8 +3579,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="369636f9-d84d-4780-ac17-a5edc7eb3920" name="pKa_pH_WS_int_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="4f49c043-1ea8-4937-9d11-b324bbefc1f9">
+              <Parameter id="92ef2351-dd2e-4070-800c-9ae7a10bceae" name="pKa_pH_WS_int_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="b2116906-c6c3-4268-ad85-6a4b9aa43d4e">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -3421,8 +3590,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="df5b6f81-af5f-42db-8ca7-4938de4a7609" name="pKa_pH_WS_int_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="1fc61ed5-bd05-49eb-8176-c59ef700b28e">
+              <Parameter id="23b63ae3-6eac-4abc-bc84-b1c0e3402878" name="pKa_pH_WS_int_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="460dc2b6-d9fa-4054-86b5-2f15c43ec82b">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -3431,8 +3601,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="028fcb23-f536-4cd5-9968-2c7d260497ed" name="pKa_pH_WS_int_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="750734de-ac46-4a04-9083-7b88d483bf60">
+              <Parameter id="b444ee7c-6dd2-48d4-92e9-de332ded3d5d" name="pKa_pH_WS_int_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="9be71a88-42ff-4d88-afde-eba07d04cc36">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -3441,8 +3612,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="80ef2821-58e0-4ae9-a169-1687f273a3a8" name="pKa_pH_WS_int_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="2e2b537a-56f9-4853-a896-836d001cef96">
+              <Parameter id="1036a53b-9d1b-4376-b4b9-164ff9f602dd" name="pKa_pH_WS_int_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="a4c0110e-a1aa-4df5-a895-37191e8ac266">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -3451,8 +3623,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="44c35a23-a2f0-4463-8667-2cbcc913f0a4" name="pKa_pH_WS_int_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="76e510d3-bd1f-46bf-abf9-9b17c616d890">
+              <Parameter id="f2e22945-0047-456d-b281-96bf333ae039" name="pKa_pH_WS_int_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="f9610766-8bad-4e87-9d6a-a671b6de9522">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -3461,8 +3634,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="933140cf-3041-4360-90e2-0b46b9b6c78c" name="pKa_pH_WS_int_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="d1891477-aa42-4a88-b977-bc61b5eb60d4">
+              <Parameter id="1d9b5e1f-36e4-4266-b547-9a5206865ae2" name="pKa_pH_WS_int_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ee62fd06-6d00-41ea-8f70-fa85af95d614">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -3471,8 +3645,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="b8f539a3-dbfa-4750-8ebf-7eaa74057244" name="pKa_pH_WS_int_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="40f3a995-dbce-4715-9122-aeb923deb64f">
+              <Parameter id="6439e30e-1bf3-4664-b153-ec52407c888f" name="pKa_pH_WS_int_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="dda92b19-f9b6-4c4a-9061-3041d4f66aee">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -3481,8 +3656,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="84299ff7-e99c-4cad-b541-701f027abd24" name="pKa_pH_WS_int_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="0b4e5cfb-f203-483c-91c7-d474272aaa03">
+              <Parameter id="ad0f3a6e-f421-4f5b-9b97-fe1bd5aaf38b" name="pKa_pH_WS_int_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="0d9e2921-3387-4e75-babe-cc712a152935">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -3491,8 +3667,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="62169255-79de-4b72-8471-5b4fa7639268" name="pKa_pH_WS_int_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="564a8b31-8203-4fdc-adc0-1b82dc29b4e9">
+              <Parameter id="001b5b14-388b-4f31-b9a7-f265e1f57f02" name="pKa_pH_WS_int_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="bf4ff234-093e-4fe9-9996-7a1372bf108c">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -3503,7 +3680,7 @@
           </HelpParameters>
           <FormulaCache>
             <Formulas>
-              <Formula id="0e130ebc-072d-4736-9817-a222d26a6a17" name="PARAM_pKa_pH_WS_bc_F1" formula="CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1">
+              <Formula id="9bdb9bbb-412b-4799-83dd-0d6726ac8d58" name="PARAM_pKa_pH_WS_bc_F1" formula="CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1">
                 <Paths>
                   <Path path="2" as="3" />
                   <Path path="52" as="53" />
@@ -3511,7 +3688,7 @@
                   <Path path="56" as="57" />
                 </Paths>
               </Formula>
-              <Formula id="14adf8a8-619d-4dfc-861a-bd0144cfa834" name="PARAM_pKa_pH_WS_bc_F2" formula="CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1">
+              <Formula id="c68f7291-e992-4277-b7cb-8bb2c57cd0ce" name="PARAM_pKa_pH_WS_bc_F2" formula="CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1">
                 <Paths>
                   <Path path="4" as="5" />
                   <Path path="52" as="53" />
@@ -3519,7 +3696,7 @@
                   <Path path="56" as="57" />
                 </Paths>
               </Formula>
-              <Formula id="7b6d36f2-46c0-4af7-8a7f-6cdc6403cefb" name="PARAM_pKa_pH_WS_bc_F3" formula="CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1">
+              <Formula id="90b003ac-b0a5-4400-8d0a-0b4c706913ae" name="PARAM_pKa_pH_WS_bc_F3" formula="CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1">
                 <Paths>
                   <Path path="6" as="7" />
                   <Path path="52" as="53" />
@@ -3527,63 +3704,63 @@
                   <Path path="56" as="57" />
                 </Paths>
               </Formula>
-              <Formula id="43282724-ac4c-4c23-bab0-1162e3fd6076" name="PARAM_pKa_pH_WS_bc_K1" formula="F1*F2*F3">
+              <Formula id="3a77518a-b24d-466e-9543-e00b431ce2be" name="PARAM_pKa_pH_WS_bc_K1" formula="F1*F2*F3">
                 <Paths>
                   <Path path="62" as="63" />
                   <Path path="64" as="65" />
                   <Path path="66" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="a170792b-b510-4cda-b447-90eadd06286d" name="PARAM_pKa_pH_WS_bc_K2" formula="(1-F1)*F2*F3">
+              <Formula id="b11fb6e6-d041-4b05-9829-17e30c0467e1" name="PARAM_pKa_pH_WS_bc_K2" formula="(1-F1)*F2*F3">
                 <Paths>
                   <Path path="62" as="63" />
                   <Path path="64" as="65" />
                   <Path path="66" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="78507cf8-27a8-4904-bb9b-10a91f0c97d0" name="PARAM_pKa_pH_WS_bc_K3" formula="F1*(1-F2)*F3">
+              <Formula id="dafad48d-f6ec-41ba-808b-5a980b88e17a" name="PARAM_pKa_pH_WS_bc_K3" formula="F1*(1-F2)*F3">
                 <Paths>
                   <Path path="62" as="63" />
                   <Path path="64" as="65" />
                   <Path path="66" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="34847dc2-3ca2-4944-a0a4-4d98501f33a6" name="PARAM_pKa_pH_WS_bc_K4" formula="F1*F2*(1-F3)">
+              <Formula id="f227dc95-c36e-49e9-9dd6-9d14790c19b9" name="PARAM_pKa_pH_WS_bc_K4" formula="F1*F2*(1-F3)">
                 <Paths>
                   <Path path="62" as="63" />
                   <Path path="64" as="65" />
                   <Path path="66" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="e5336433-62c2-41a8-a7d4-74877d6d175e" name="PARAM_pKa_pH_WS_bc_K5" formula="(1-F1)*(1-F2)*F3">
+              <Formula id="8f850fc1-b285-4adc-b60b-145b9871f6a4" name="PARAM_pKa_pH_WS_bc_K5" formula="(1-F1)*(1-F2)*F3">
                 <Paths>
                   <Path path="62" as="63" />
                   <Path path="64" as="65" />
                   <Path path="66" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="cd30cc62-a4ed-414c-9dbd-40771e2165f3" name="PARAM_pKa_pH_WS_bc_K6" formula="(1-F1)*F2*(1-F3)">
+              <Formula id="54dc6148-2211-43f1-8e9c-03f4153e95b6" name="PARAM_pKa_pH_WS_bc_K6" formula="(1-F1)*F2*(1-F3)">
                 <Paths>
                   <Path path="62" as="63" />
                   <Path path="64" as="65" />
                   <Path path="66" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="c202fda3-183a-4e79-ada4-1ff475e32f0a" name="PARAM_pKa_pH_WS_bc_K7" formula="F1*(1-F2)*(1-F3)">
+              <Formula id="b6d2de95-bdd0-42cd-96a5-f0fc54d9d658" name="PARAM_pKa_pH_WS_bc_K7" formula="F1*(1-F2)*(1-F3)">
                 <Paths>
                   <Path path="62" as="63" />
                   <Path path="64" as="65" />
                   <Path path="66" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="bbdac73f-8231-4b71-9861-e12e7d4578ba" name="PARAM_pKa_pH_WS_bc_K8" formula="(1-F1)*(1-F2)*(1-F3)">
+              <Formula id="ecaa2a36-c9cd-4daa-9b38-81adfd4cc9e4" name="PARAM_pKa_pH_WS_bc_K8" formula="(1-F1)*(1-F2)*(1-F3)">
                 <Paths>
                   <Path path="62" as="63" />
                   <Path path="64" as="65" />
                   <Path path="66" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="f9d086e0-e20f-4af4-9477-9588aefd1b76" name="PARAM_pKa_pH_WS_pls_F1" formula="CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1">
+              <Formula id="e2441d79-d13e-4c76-bf4f-7c378eb2932b" name="PARAM_pKa_pH_WS_pls_F1" formula="CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1">
                 <Paths>
                   <Path path="2" as="3" />
                   <Path path="52" as="53" />
@@ -3591,7 +3768,7 @@
                   <Path path="68" as="57" />
                 </Paths>
               </Formula>
-              <Formula id="ee466d55-b3de-4654-98c7-26ad1e30a53c" name="PARAM_pKa_pH_WS_pls_F2" formula="CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1">
+              <Formula id="cf268419-0ae0-4e5e-b82d-6d18285f5db5" name="PARAM_pKa_pH_WS_pls_F2" formula="CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1">
                 <Paths>
                   <Path path="4" as="5" />
                   <Path path="52" as="53" />
@@ -3599,7 +3776,7 @@
                   <Path path="68" as="57" />
                 </Paths>
               </Formula>
-              <Formula id="c52757b9-5e06-4ee3-b8b3-c8eda65e09e9" name="PARAM_pKa_pH_WS_pls_F3" formula="CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1">
+              <Formula id="61403ca7-32fe-44d1-83c6-861d152a7704" name="PARAM_pKa_pH_WS_pls_F3" formula="CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1">
                 <Paths>
                   <Path path="6" as="7" />
                   <Path path="52" as="53" />
@@ -3607,63 +3784,63 @@
                   <Path path="68" as="57" />
                 </Paths>
               </Formula>
-              <Formula id="41436d31-3f09-4260-8bb2-3af6c6612238" name="PARAM_pKa_pH_WS_pls_K1" formula="F1*F2*F3">
+              <Formula id="41cb6658-9221-431f-95f1-079a5e85368f" name="PARAM_pKa_pH_WS_pls_K1" formula="F1*F2*F3">
                 <Paths>
                   <Path path="69" as="63" />
                   <Path path="70" as="65" />
                   <Path path="71" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="34d258d8-9147-4544-8584-b0f0e9806c34" name="PARAM_pKa_pH_WS_pls_K2" formula="(1-F1)*F2*F3">
+              <Formula id="3fa4194a-1832-424d-8a62-b43ec8555bf6" name="PARAM_pKa_pH_WS_pls_K2" formula="(1-F1)*F2*F3">
                 <Paths>
                   <Path path="69" as="63" />
                   <Path path="70" as="65" />
                   <Path path="71" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="acd00a49-8a79-41f7-bd98-159fe90a9d08" name="PARAM_pKa_pH_WS_pls_K3" formula="F1*(1-F2)*F3">
+              <Formula id="9dcd8cbd-7d4d-470d-8ac1-283498665d4d" name="PARAM_pKa_pH_WS_pls_K3" formula="F1*(1-F2)*F3">
                 <Paths>
                   <Path path="69" as="63" />
                   <Path path="70" as="65" />
                   <Path path="71" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="94b3ad28-5ab4-4a69-8817-9c398ed6efcf" name="PARAM_pKa_pH_WS_pls_K4" formula="F1*F2*(1-F3)">
+              <Formula id="787594e8-6378-4ebb-9ae8-9541898653b3" name="PARAM_pKa_pH_WS_pls_K4" formula="F1*F2*(1-F3)">
                 <Paths>
                   <Path path="69" as="63" />
                   <Path path="70" as="65" />
                   <Path path="71" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="4a4e44c6-d611-4449-ba1b-8249030df23e" name="PARAM_pKa_pH_WS_pls_K5" formula="(1-F1)*(1-F2)*F3">
+              <Formula id="0ebf9ffc-c360-4c89-990a-c4ca70014415" name="PARAM_pKa_pH_WS_pls_K5" formula="(1-F1)*(1-F2)*F3">
                 <Paths>
                   <Path path="69" as="63" />
                   <Path path="70" as="65" />
                   <Path path="71" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="a305ef8f-488b-4d7d-87a7-56793045ae9d" name="PARAM_pKa_pH_WS_pls_K6" formula="(1-F1)*F2*(1-F3)">
+              <Formula id="701dffed-ea2d-4f7d-b5bc-f577f549cd2c" name="PARAM_pKa_pH_WS_pls_K6" formula="(1-F1)*F2*(1-F3)">
                 <Paths>
                   <Path path="69" as="63" />
                   <Path path="70" as="65" />
                   <Path path="71" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="4bf0dba1-7857-45f8-bd8f-32835d9d2b90" name="PARAM_pKa_pH_WS_pls_K7" formula="F1*(1-F2)*(1-F3)">
+              <Formula id="ce0b2f4b-a7ec-4c08-8049-c87630202557" name="PARAM_pKa_pH_WS_pls_K7" formula="F1*(1-F2)*(1-F3)">
                 <Paths>
                   <Path path="69" as="63" />
                   <Path path="70" as="65" />
                   <Path path="71" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="5f4c5f8d-f931-4be3-9885-df4fc85c1b7d" name="PARAM_pKa_pH_WS_pls_K8" formula="(1-F1)*(1-F2)*(1-F3)">
+              <Formula id="87cdd92a-241b-438f-bfb8-845f34ecb530" name="PARAM_pKa_pH_WS_pls_K8" formula="(1-F1)*(1-F2)*(1-F3)">
                 <Paths>
                   <Path path="69" as="63" />
                   <Path path="70" as="65" />
                   <Path path="71" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="27e8333b-2089-417f-97da-1a958f4431ef" name="PARAM_pKa_pH_WS_cell_F1" formula="CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1">
+              <Formula id="9487ef9f-17c3-4d85-98d0-df51320e626c" name="PARAM_pKa_pH_WS_cell_F1" formula="CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1">
                 <Paths>
                   <Path path="72" as="57" />
                   <Path path="41" as="3" />
@@ -3671,7 +3848,7 @@
                   <Path path="74" as="55" />
                 </Paths>
               </Formula>
-              <Formula id="a4fcaa3b-5acd-4b84-bd80-a728cb32b78d" name="PARAM_pKa_pH_WS_cell_F2" formula="CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1">
+              <Formula id="696e3da0-57ce-484e-8f1a-b7771818e2a3" name="PARAM_pKa_pH_WS_cell_F2" formula="CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1">
                 <Paths>
                   <Path path="72" as="57" />
                   <Path path="42" as="5" />
@@ -3679,7 +3856,7 @@
                   <Path path="75" as="59" />
                 </Paths>
               </Formula>
-              <Formula id="40446be7-cc1e-493c-8daa-b4293358019c" name="PARAM_pKa_pH_WS_cell_F3" formula="CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1">
+              <Formula id="fbdb9c9b-0b04-46f7-8d14-ef6c610aca23" name="PARAM_pKa_pH_WS_cell_F3" formula="CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1">
                 <Paths>
                   <Path path="72" as="57" />
                   <Path path="43" as="7" />
@@ -3687,63 +3864,63 @@
                   <Path path="76" as="61" />
                 </Paths>
               </Formula>
-              <Formula id="c341fe71-b034-4284-9e00-3ce8df8caa27" name="PARAM_pKa_pH_WS_cell_K1" formula="F1*F2*F3">
+              <Formula id="12659bf7-4c70-4f47-841d-f15e16056464" name="PARAM_pKa_pH_WS_cell_K1" formula="F1*F2*F3">
                 <Paths>
                   <Path path="77" as="63" />
                   <Path path="78" as="65" />
                   <Path path="79" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="3ec0debb-ac66-4fbf-b6c6-daeccb1fd906" name="PARAM_pKa_pH_WS_cell_K2" formula="(1-F1)*F2*F3">
+              <Formula id="13606054-f010-4ea7-b6e8-aa936882446d" name="PARAM_pKa_pH_WS_cell_K2" formula="(1-F1)*F2*F3">
                 <Paths>
                   <Path path="77" as="63" />
                   <Path path="78" as="65" />
                   <Path path="79" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="347aa6b5-30fd-4e71-a831-6971ef33d6e7" name="PARAM_pKa_pH_WS_cell_K3" formula="F1*(1-F2)*F3">
+              <Formula id="d0000349-f6cc-4709-9985-1c52181f87c0" name="PARAM_pKa_pH_WS_cell_K3" formula="F1*(1-F2)*F3">
                 <Paths>
                   <Path path="77" as="63" />
                   <Path path="78" as="65" />
                   <Path path="79" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="9b0de2a5-7c14-474d-8fa9-2bf3a0da3cee" name="PARAM_pKa_pH_WS_cell_K4" formula="F1*F2*(1-F3)">
+              <Formula id="0c755d27-59c3-499f-90ca-efef1f01acb0" name="PARAM_pKa_pH_WS_cell_K4" formula="F1*F2*(1-F3)">
                 <Paths>
                   <Path path="77" as="63" />
                   <Path path="78" as="65" />
                   <Path path="79" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="72f39ed2-889f-4be0-9da9-73c66bd8e795" name="PARAM_pKa_pH_WS_cell_K5" formula="(1-F1)*(1-F2)*F3">
+              <Formula id="d26f5e2d-cedb-4a13-88e4-bbc6a4a0d1e2" name="PARAM_pKa_pH_WS_cell_K5" formula="(1-F1)*(1-F2)*F3">
                 <Paths>
                   <Path path="77" as="63" />
                   <Path path="78" as="65" />
                   <Path path="79" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="0fdbd9b8-46e2-4aaa-afa8-ff564f22b7fe" name="PARAM_pKa_pH_WS_cell_K6" formula="(1-F1)*F2*(1-F3)">
+              <Formula id="23ec8c29-0b09-4f7e-8296-71c3c7dd5e6c" name="PARAM_pKa_pH_WS_cell_K6" formula="(1-F1)*F2*(1-F3)">
                 <Paths>
                   <Path path="77" as="63" />
                   <Path path="78" as="65" />
                   <Path path="79" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="71ba8505-4cb7-461e-8402-2df8d8368e7c" name="PARAM_pKa_pH_WS_cell_K7" formula="F1*(1-F2)*(1-F3)">
+              <Formula id="4794dbf6-9283-45d1-a8d5-f17574b43b4c" name="PARAM_pKa_pH_WS_cell_K7" formula="F1*(1-F2)*(1-F3)">
                 <Paths>
                   <Path path="77" as="63" />
                   <Path path="78" as="65" />
                   <Path path="79" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="0bbf2818-0ce1-4485-90cb-cda028de5a81" name="PARAM_pKa_pH_WS_cell_K8" formula="(1-F1)*(1-F2)*(1-F3)">
+              <Formula id="48cfaeb9-8e0b-4ba0-90f1-12df95ea50ec" name="PARAM_pKa_pH_WS_cell_K8" formula="(1-F1)*(1-F2)*(1-F3)">
                 <Paths>
                   <Path path="77" as="63" />
                   <Path path="78" as="65" />
                   <Path path="79" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="f43d7bab-cb68-4262-b0c1-e5822d4e1fe9" name="PARAM_pKa_pH_WS_int_F1" formula="CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1">
+              <Formula id="3c116ae9-2dc2-4440-a7bb-1421ea929e97" name="PARAM_pKa_pH_WS_int_F1" formula="CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1">
                 <Paths>
                   <Path path="80" as="57" />
                   <Path path="41" as="3" />
@@ -3751,7 +3928,7 @@
                   <Path path="74" as="55" />
                 </Paths>
               </Formula>
-              <Formula id="05e82657-cdaf-45cf-83f2-a3712757b54e" name="PARAM_pKa_pH_WS_int_F2" formula="CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1">
+              <Formula id="449b0d65-d7b7-4dca-839a-9a59262f7a69" name="PARAM_pKa_pH_WS_int_F2" formula="CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1">
                 <Paths>
                   <Path path="80" as="57" />
                   <Path path="42" as="5" />
@@ -3759,7 +3936,7 @@
                   <Path path="75" as="59" />
                 </Paths>
               </Formula>
-              <Formula id="4f49c043-1ea8-4937-9d11-b324bbefc1f9" name="PARAM_pKa_pH_WS_int_F3" formula="CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1">
+              <Formula id="b2116906-c6c3-4268-ad85-6a4b9aa43d4e" name="PARAM_pKa_pH_WS_int_F3" formula="CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1">
                 <Paths>
                   <Path path="80" as="57" />
                   <Path path="43" as="7" />
@@ -3767,56 +3944,56 @@
                   <Path path="76" as="61" />
                 </Paths>
               </Formula>
-              <Formula id="1fc61ed5-bd05-49eb-8176-c59ef700b28e" name="PARAM_pKa_pH_WS_int_K1" formula="F1*F2*F3">
+              <Formula id="460dc2b6-d9fa-4054-86b5-2f15c43ec82b" name="PARAM_pKa_pH_WS_int_K1" formula="F1*F2*F3">
                 <Paths>
                   <Path path="81" as="63" />
                   <Path path="82" as="65" />
                   <Path path="83" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="750734de-ac46-4a04-9083-7b88d483bf60" name="PARAM_pKa_pH_WS_int_K2" formula="(1-F1)*F2*F3">
+              <Formula id="9be71a88-42ff-4d88-afde-eba07d04cc36" name="PARAM_pKa_pH_WS_int_K2" formula="(1-F1)*F2*F3">
                 <Paths>
                   <Path path="81" as="63" />
                   <Path path="82" as="65" />
                   <Path path="83" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="2e2b537a-56f9-4853-a896-836d001cef96" name="PARAM_pKa_pH_WS_int_K3" formula="F1*(1-F2)*F3">
+              <Formula id="a4c0110e-a1aa-4df5-a895-37191e8ac266" name="PARAM_pKa_pH_WS_int_K3" formula="F1*(1-F2)*F3">
                 <Paths>
                   <Path path="81" as="63" />
                   <Path path="82" as="65" />
                   <Path path="83" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="76e510d3-bd1f-46bf-abf9-9b17c616d890" name="PARAM_pKa_pH_WS_int_K4" formula="F1*F2*(1-F3)">
+              <Formula id="f9610766-8bad-4e87-9d6a-a671b6de9522" name="PARAM_pKa_pH_WS_int_K4" formula="F1*F2*(1-F3)">
                 <Paths>
                   <Path path="81" as="63" />
                   <Path path="82" as="65" />
                   <Path path="83" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="d1891477-aa42-4a88-b977-bc61b5eb60d4" name="PARAM_pKa_pH_WS_int_K5" formula="(1-F1)*(1-F2)*F3">
+              <Formula id="ee62fd06-6d00-41ea-8f70-fa85af95d614" name="PARAM_pKa_pH_WS_int_K5" formula="(1-F1)*(1-F2)*F3">
                 <Paths>
                   <Path path="81" as="63" />
                   <Path path="82" as="65" />
                   <Path path="83" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="40f3a995-dbce-4715-9122-aeb923deb64f" name="PARAM_pKa_pH_WS_int_K6" formula="(1-F1)*F2*(1-F3)">
+              <Formula id="dda92b19-f9b6-4c4a-9061-3041d4f66aee" name="PARAM_pKa_pH_WS_int_K6" formula="(1-F1)*F2*(1-F3)">
                 <Paths>
                   <Path path="81" as="63" />
                   <Path path="82" as="65" />
                   <Path path="83" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="0b4e5cfb-f203-483c-91c7-d474272aaa03" name="PARAM_pKa_pH_WS_int_K7" formula="F1*(1-F2)*(1-F3)">
+              <Formula id="0d9e2921-3387-4e75-babe-cc712a152935" name="PARAM_pKa_pH_WS_int_K7" formula="F1*(1-F2)*(1-F3)">
                 <Paths>
                   <Path path="81" as="63" />
                   <Path path="82" as="65" />
                   <Path path="83" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="564a8b31-8203-4fdc-adc0-1b82dc29b4e9" name="PARAM_pKa_pH_WS_int_K8" formula="(1-F1)*(1-F2)*(1-F3)">
+              <Formula id="bf4ff234-093e-4fe9-9996-7a1372bf108c" name="PARAM_pKa_pH_WS_int_K8" formula="(1-F1)*(1-F2)*(1-F3)">
                 <Paths>
                   <Path path="81" as="63" />
                   <Path path="82" as="65" />
@@ -3912,10 +4089,11 @@
             </StringMap>
           </FormulaCache>
         </CoreCalculationMethod>
-        <CoreCalculationMethod id="19485987-f9b9-4264-b916-a822c515ca05" name="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim" icon="CoreCalculationMethod" bbVersion="0" category="DiffusionIntCell">
+        <CoreCalculationMethod id="b4d19ed5-0f98-4f39-ac15-6c672b56db5d" name="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim" icon="CoreCalculationMethod" bbVersion="0" category="DiffusionIntCell">
+          <Creation createdAt="5248846165144658995" createdBy="Michael" creationMode="New" origin="Other" />
           <OutputFormulas>
             <KeyValue>
-              <Formula id="1bdb2be2-0f2f-41b8-917f-1cc347927245" name="PARAM_P_rbc_pls_factor_WS" formula="K1+ (K2 +K3 +K4)* base ^ 1 + K5* base ^ max(CT0+CT1;-CT0-CT1) +K6* base ^ max(CT0+CT2;-CT0-CT2) +K7* base ^ max(CT2+CT1;-CT2-CT1) +K8* base ^ max(CT0+CT1+CT2;-CT0-CT1-CT2)">
+              <Formula id="b81d7073-2640-415a-9a8a-890d327ab666" name="PARAM_P_rbc_pls_factor_WS" formula="K1+ (K2 +K3 +K4)* base ^ 1 + K5* base ^ max(CT0+CT1;-CT0-CT1) +K6* base ^ max(CT0+CT2;-CT0-CT2) +K7* base ^ max(CT2+CT1;-CT2-CT1) +K8* base ^ max(CT0+CT1+CT2;-CT0-CT1-CT2)">
                 <Paths>
                   <Path path="0" as="1" />
                   <Path path="2" as="3" />
@@ -3940,7 +4118,7 @@
               </ParameterDescriptor>
             </KeyValue>
             <KeyValue>
-              <Formula id="a89a4bb1-4eda-4c1e-a4e0-292eef6884e6" name="PARAM_P_pls_rbc_factor_WS" formula="K1+ (K2 +K3 +K4)* base ^ 1 + K5* base ^ max(CT0+CT1;-CT0-CT1) +K6* base ^ max(CT0+CT2;-CT0-CT2) +K7* base ^ max(CT2+CT1;-CT2-CT1) +K8* base ^ max(CT0+CT1+CT2;-CT0-CT1-CT2)">
+              <Formula id="47ba364a-1b08-445c-915e-aeb31f13e86a" name="PARAM_P_pls_rbc_factor_WS" formula="K1+ (K2 +K3 +K4)* base ^ 1 + K5* base ^ max(CT0+CT1;-CT0-CT1) +K6* base ^ max(CT0+CT2;-CT0-CT2) +K7* base ^ max(CT2+CT1;-CT2-CT1) +K8* base ^ max(CT0+CT1+CT2;-CT0-CT1-CT2)">
                 <Paths>
                   <Path path="0" as="1" />
                   <Path path="2" as="3" />
@@ -3965,7 +4143,7 @@
               </ParameterDescriptor>
             </KeyValue>
             <KeyValue>
-              <Formula id="8a11f70b-3c5d-49a1-89b3-66872863b9d5" name="PARAM_P_cell_int_factor_WS" formula="K1+ (K2 +K3 +K4)* base ^ 1 + K5* base ^ max(CT0+CT1;-CT0-CT1) +K6* base ^ max(CT0+CT2;-CT0-CT2) +K7* base ^ max(CT2+CT1;-CT2-CT1) +K8* base ^ max(CT0+CT1+CT2;-CT0-CT1-CT2)">
+              <Formula id="6b5a19d7-bc6f-4ba8-a09f-01a08770168f" name="PARAM_P_cell_int_factor_WS" formula="K1+ (K2 +K3 +K4)* base ^ 1 + K5* base ^ max(CT0+CT1;-CT0-CT1) +K6* base ^ max(CT0+CT2;-CT0-CT2) +K7* base ^ max(CT2+CT1;-CT2-CT1) +K8* base ^ max(CT0+CT1+CT2;-CT0-CT1-CT2)">
                 <Paths>
                   <Path path="32" as="9" />
                   <Path path="33" as="11" />
@@ -3990,7 +4168,7 @@
               </ParameterDescriptor>
             </KeyValue>
             <KeyValue>
-              <Formula id="50e85d00-d1f3-486c-9b7c-0960e74e03d9" name="PARAM_P_int_cell_factor_WS" formula="K1+ (K2 +K3 +K4)* base ^ 1 + K5* base ^ max(CT0+CT1;-CT0-CT1) +K6* base ^ max(CT0+CT2;-CT0-CT2) +K7* base ^ max(CT2+CT1;-CT2-CT1) +K8* base ^ max(CT0+CT1+CT2;-CT0-CT1-CT2)">
+              <Formula id="e082d964-2463-4fd9-b37c-ceea8d3ce2a0" name="PARAM_P_int_cell_factor_WS" formula="K1+ (K2 +K3 +K4)* base ^ 1 + K5* base ^ max(CT0+CT1;-CT0-CT1) +K6* base ^ max(CT0+CT2;-CT0-CT2) +K7* base ^ max(CT2+CT1;-CT2-CT1) +K8* base ^ max(CT0+CT1+CT2;-CT0-CT1-CT2)">
                 <Paths>
                   <Path path="44" as="9" />
                   <Path path="45" as="11" />
@@ -4017,8 +4195,9 @@
           </OutputFormulas>
           <HelpParameters>
             <KeyValue>
-              <Parameter id="37b37827-b444-446c-83a0-8aa677b738e1" name="pKa_pH_WS_bc_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="07d54096-8fbd-45a7-9963-13fce294e4fa">
+              <Parameter id="b855563c-afb1-40bd-ac29-772dd05c910a" name="pKa_pH_WS_bc_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="1eb54f10-3c33-44cf-965a-d81550882807">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -4027,8 +4206,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="3942b73e-3b92-4fce-8311-f71877bdc92d" name="pKa_pH_WS_bc_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="ff3116ab-b1d1-474d-8282-f3f63ea9fbae">
+              <Parameter id="39499079-3983-474c-8800-146f8488e447" name="pKa_pH_WS_bc_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="85e4d339-33f6-4c77-b4fc-f9dc5aa0f279">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -4037,8 +4217,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="3eb7fec5-71bb-41c5-a47c-4840fc571117" name="pKa_pH_WS_bc_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="37ea14ba-0612-4be5-8a86-4f9c678b275c">
+              <Parameter id="f7f2e91d-a38d-4140-a4b4-53ed79ddab93" name="pKa_pH_WS_bc_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="9e20a8b0-bc48-4dfc-8a89-fbe71e583d40">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -4047,8 +4228,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="76da6e98-7424-4bd4-a1a2-2f05fc238c6a" name="pKa_pH_WS_bc_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="d5af835f-c53c-4b14-95c4-8ce852fdcedb">
+              <Parameter id="e3d478b7-9ec3-43fa-8be6-2d67d26ceb77" name="pKa_pH_WS_bc_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="7445e756-c254-4e40-91fc-bffd5cc0aec6">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -4057,8 +4239,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="dcf36e0b-200f-44fe-b727-e37b568f3585" name="pKa_pH_WS_bc_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="9edf4a8d-a210-4565-be16-be03588f1a2d">
+              <Parameter id="dbdf798d-5ac9-41f7-a54b-7c0daa558412" name="pKa_pH_WS_bc_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="98431dff-5b74-4cde-8d61-ec87e2314f90">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -4067,8 +4250,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="8c89770c-c554-408d-b264-1f1fcc7ac0c4" name="pKa_pH_WS_bc_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="7a519457-d1d9-4e3e-91d6-de090c4b2cbf">
+              <Parameter id="863d7826-743c-45b1-a337-658b2b67a7ec" name="pKa_pH_WS_bc_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="4bc7b2c7-83ab-49f7-835d-84a80d7b6a3e">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -4077,8 +4261,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="b0cb17ae-a657-4fc5-9b51-90a5b2c7e6c4" name="pKa_pH_WS_bc_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="4ea19b3d-2df7-4657-a54f-da661ed0d030">
+              <Parameter id="388f613c-0047-403f-a03d-05e7709b3ace" name="pKa_pH_WS_bc_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="8196b10b-6cbb-4d7b-9c8f-2cc7ea07d008">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -4087,8 +4272,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="66944304-bc76-4433-9e1f-eaec11b3b6d0" name="pKa_pH_WS_bc_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="6a3de140-da6a-4ccf-a7dd-acd87bb7b41c">
+              <Parameter id="ae5b2cb4-fd22-4fb6-9b2d-7d6708cdc7ad" name="pKa_pH_WS_bc_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="c69a4a1a-be63-4cd9-b8a7-5f6ec57792a8">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -4097,8 +4283,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="19b863eb-c137-4fbd-bdb3-7d5a6c929b67" name="pKa_pH_WS_bc_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="3fbea912-f66c-45b0-986a-a51fbd3d6b77">
+              <Parameter id="6580bbef-db76-455b-952b-34bd41d7f03b" name="pKa_pH_WS_bc_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="523159b1-3144-4735-bbc8-368f796cda10">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -4107,8 +4294,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="252031c2-ab7f-4c03-b04d-7230c02b1977" name="pKa_pH_WS_bc_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="a78b888b-fed8-4eb8-93f9-1cedab164acc">
+              <Parameter id="51c7678e-95c5-465d-a3f1-dea3e6e9c6a3" name="pKa_pH_WS_bc_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="12a17054-ba4b-41c3-ad26-69740ce5596a">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -4117,8 +4305,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="382b4556-2a6f-4027-b0d3-882496e8c4b1" name="pKa_pH_WS_bc_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="a5ecc09e-8984-4a2d-93f0-a3d3b9af7c20">
+              <Parameter id="d732ede7-97ce-4c15-a8ec-1ca55b18927d" name="pKa_pH_WS_bc_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="e5908b33-2cf6-4188-b943-ec93fb3a320e">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -4127,8 +4316,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="a1512f7f-a47d-429e-978c-a5de406d1176" name="pKa_pH_WS_pls_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="b61d37db-4bdd-4343-8909-ffe45a5743e2">
+              <Parameter id="080f6dd8-b9ee-4726-8381-afab3b5b6897" name="pKa_pH_WS_pls_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="04a2a4c0-0ef1-4d15-84a1-44266d32255e">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -4137,8 +4327,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="bb3b8ee9-e9ca-4689-8ea8-f682096e5b53" name="pKa_pH_WS_pls_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="37e83663-b314-411d-8ca2-2e9781a526f7">
+              <Parameter id="7d40a16b-0b2a-446c-9c31-a4add498973e" name="pKa_pH_WS_pls_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="f2ee8aba-4f45-4666-8dd6-f47819e7b2b8">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -4147,8 +4338,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="ed637407-8e33-45ae-a4e5-7627a12f8606" name="pKa_pH_WS_pls_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="d78db17c-e7d2-4c14-aa32-379f115b35d4">
+              <Parameter id="1e85485e-e93b-4185-ba5a-90542332a552" name="pKa_pH_WS_pls_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="bf0bc6b2-f48f-411d-91f9-dc512a14d691">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -4157,8 +4349,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="1c41b9b2-9154-4664-8bb7-465075ea6571" name="pKa_pH_WS_pls_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="6587810f-e5cc-4244-bf02-29ddded3a401">
+              <Parameter id="b92f0743-1b5a-4b0d-8898-4485cc0fcb46" name="pKa_pH_WS_pls_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="d264fa00-23ab-4bf6-9703-f4f5ebf9a592">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -4167,8 +4360,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="be03c433-9dfd-478a-be89-bd406925db15" name="pKa_pH_WS_pls_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="83a7b332-9024-455d-a897-506971f78c9e">
+              <Parameter id="ce1a0fa1-567d-43dc-834f-4f7d6826cd77" name="pKa_pH_WS_pls_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="e3104349-0bfe-404c-be29-9be6de751318">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -4177,8 +4371,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="ea891868-e2e6-4dfc-8fb6-2622dae8ce28" name="pKa_pH_WS_pls_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="0574df10-3196-4539-8a73-2d1d18be3db6">
+              <Parameter id="dc54d1b7-f153-48f0-9158-5a27db3ebc54" name="pKa_pH_WS_pls_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="4258d042-d4a4-47aa-9bb8-510e22b89c29">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -4187,8 +4382,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="6f77c5e8-bc8a-4ab0-8348-f4bd827c8bac" name="pKa_pH_WS_pls_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="c09ccbd1-09a4-484e-b75c-c85f5b3bbde0">
+              <Parameter id="d816de52-44ce-4555-87a3-2e671a2c6776" name="pKa_pH_WS_pls_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="6392e0d7-a4a5-46f3-b268-40bae4cd8176">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -4197,8 +4393,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="7e9362be-143e-4f0c-8097-accf9696f738" name="pKa_pH_WS_pls_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="6c54588e-4137-4397-bbcc-bb6bde3d3282">
+              <Parameter id="03c93af6-4491-4960-9570-14cfab7bb228" name="pKa_pH_WS_pls_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="945ca29f-981e-4a05-b5a2-2e815ec2d7a7">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -4207,8 +4404,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="dccae099-0bd3-4ee1-a37c-bf1c35707a3c" name="pKa_pH_WS_pls_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="c046e1ab-7b25-426e-b4fc-80b08343ec99">
+              <Parameter id="9358e3dd-5da3-4ae5-bb42-d1c0bf9ad8f9" name="pKa_pH_WS_pls_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="a6d1f674-70ad-4ed1-9bfc-51a53757e2fe">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -4217,8 +4415,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="04db7506-439f-481f-9dda-330aabdc78af" name="pKa_pH_WS_pls_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="6aa97393-b850-4918-9254-026fadc0ac2a">
+              <Parameter id="c39b2713-5290-40a7-9f24-c52384674d6a" name="pKa_pH_WS_pls_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="57729100-d5be-4bbb-bce4-a1345096366d">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -4227,8 +4426,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="da3da026-1d60-46b3-948f-2f62789ca5cd" name="pKa_pH_WS_pls_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="2fbd5b94-d2da-4636-96c3-54e9f0f09118">
+              <Parameter id="737c8706-fb58-4ef6-9302-5d09a5a47703" name="pKa_pH_WS_pls_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="7faf243d-c517-49a2-bd53-a78309cf0f1c">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -4237,8 +4437,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="47ba74f9-75f4-4a94-96b1-5160081ec821" name="pKa_pH_WS_cell_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="9318f6d8-475b-4a6d-bdd7-d2951d8928ff">
+              <Parameter id="9a52907c-0f21-4b15-9a5e-0adf3d37e86b" name="pKa_pH_WS_cell_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="e4740e10-cb67-4c02-a76a-9a41e8b7398c">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -4247,8 +4448,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="f99058b8-0110-4e07-ac2a-714317aac9bf" name="pKa_pH_WS_cell_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="f1569433-7063-453d-9a69-6574005ed293">
+              <Parameter id="8431c23f-4d39-4b32-8808-b082e81e9e01" name="pKa_pH_WS_cell_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="13026517-1df0-4543-98ff-c996a3efcfbf">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -4257,8 +4459,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="58f4755a-bc70-4f6f-9dd8-e48e1abe09d0" name="pKa_pH_WS_cell_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="99a8f98c-3af3-4b33-9d64-3d4b7ef1a75d">
+              <Parameter id="3339d30a-e31d-46b9-86de-3730e9f6fe47" name="pKa_pH_WS_cell_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="54c3a25f-cda4-4967-881a-5f76a785e4e4">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -4267,8 +4470,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="39c604da-9f31-40db-a2de-507a728987c1" name="pKa_pH_WS_cell_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="c8d3983f-9287-4f28-9c9e-56a54b45682b">
+              <Parameter id="e328d416-6982-44d7-bd42-04a06d948084" name="pKa_pH_WS_cell_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="501fabd0-eab2-49c8-9ead-49fe7cafaeb0">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -4277,8 +4481,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="413475bc-0e01-44bd-8353-8df8fec826ae" name="pKa_pH_WS_cell_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="08f04380-7221-4d5f-8309-b0eb653b9618">
+              <Parameter id="bee2ffa3-edd2-4075-ab95-c8c3fb166237" name="pKa_pH_WS_cell_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="0dc082de-0bc8-4c5a-a101-eabca41f8d2d">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -4287,8 +4492,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="8ee9a3c6-1742-48c9-aac8-0f0c6c987354" name="pKa_pH_WS_cell_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="eb4899b7-e220-4321-b54f-a49c072c0d49">
+              <Parameter id="492b2ab6-2cd1-44f3-a853-3e4e251f69e4" name="pKa_pH_WS_cell_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="6e1cfa69-69d1-4183-ab0f-b3ac569c3836">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -4297,8 +4503,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="83ab3fa1-1847-4445-ad6f-8587ce18cd57" name="pKa_pH_WS_cell_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="2737fddb-030e-4c03-bce4-fa951906d4ab">
+              <Parameter id="2247c9db-abf2-4d65-ab46-8a811b9b5a97" name="pKa_pH_WS_cell_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="947632fb-e711-44c5-9722-299cd270cd01">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -4307,8 +4514,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="8fd876aa-7d19-4f07-8b70-7de6b2093660" name="pKa_pH_WS_cell_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="30d65357-2555-4608-9e4d-2ab162b27e15">
+              <Parameter id="368b7db7-edde-42cf-83db-193d4dc0bebb" name="pKa_pH_WS_cell_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="f6a37965-1702-4466-832e-12d95f1e6f19">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -4317,8 +4525,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="016a4dda-74ea-42cf-b4ab-1b75f7ff16c4" name="pKa_pH_WS_cell_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="feb4a455-9a9f-4ff6-852b-45b49446ad74">
+              <Parameter id="30aab852-0078-4e9e-b671-00a79f04d1c2" name="pKa_pH_WS_cell_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="830b000e-2f04-45d2-9771-76a35e17b793">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -4327,8 +4536,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="6e80ef65-a397-4cdd-ac29-877fbdf1ce53" name="pKa_pH_WS_cell_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="79e90f49-0ccd-4bdb-b075-43c8fd658daa">
+              <Parameter id="feddc640-09a8-40cd-9fa4-01c60cfa7891" name="pKa_pH_WS_cell_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ce676edc-b757-4d25-b115-14a562324351">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -4337,8 +4547,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="02b6f27e-672b-4861-9cd7-2579b34a6ad0" name="pKa_pH_WS_cell_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="81c8ceed-60d3-49af-a61d-6e3923e8b625">
+              <Parameter id="8f8889be-a896-4832-b456-b1e8c62b8cfc" name="pKa_pH_WS_cell_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="17a55d76-3026-41fb-81e8-ad709687ed88">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -4347,8 +4558,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="b8d1e21b-4d0c-42fc-9e66-b2889241e99d" name="pKa_pH_WS_int_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="f73eadfe-d500-45dd-bb21-1b76b9ed2759">
+              <Parameter id="7f796b3b-9c29-4e8b-834b-fda10d6ab835" name="pKa_pH_WS_int_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="cffc4024-623f-426d-8528-7ba78f715cc3">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -4357,8 +4569,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="fc18ab76-f688-4624-8941-1cd86e3f552b" name="pKa_pH_WS_int_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="d026189c-1fb9-4a37-8e8c-f4c32ab1a372">
+              <Parameter id="11c0bea0-e1cc-4f76-b229-2f8bc8ea06c3" name="pKa_pH_WS_int_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="784e3399-9fa1-458a-8765-20ca486d501d">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -4367,8 +4580,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="1f14735a-4e3e-4bae-98f5-46876288bfe3" name="pKa_pH_WS_int_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="ce122b40-985f-4d0d-8447-ddc0a2341da4">
+              <Parameter id="b3da43cf-540f-40c0-995b-7711d2de071e" name="pKa_pH_WS_int_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="f1f48185-b04a-4b6d-bb80-fe69b88045c6">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -4377,8 +4591,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="9bec154c-a99c-43d3-b4b8-40e9c28e84be" name="pKa_pH_WS_int_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="b9495cbd-90e9-493d-beca-87a403200b4d">
+              <Parameter id="6fd546eb-fab5-4d99-b6de-f019734a0d5f" name="pKa_pH_WS_int_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="44b91625-71e6-47a5-b62a-88837fefdfc3">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -4387,8 +4602,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="a81e4476-7470-4290-99fa-0ab97d92b49c" name="pKa_pH_WS_int_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="0e7d9d3a-8f58-4466-905f-0de1f72ef361">
+              <Parameter id="fa2857cb-cfe2-4ad1-8e83-a6e86065d9db" name="pKa_pH_WS_int_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="22516428-e9d5-4d51-8fde-20831ab6262c">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -4397,8 +4613,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="6a5c5a59-de8d-463a-b2c6-30ea35c647c1" name="pKa_pH_WS_int_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="c16e69e3-92a8-4773-aa2c-155446cad03c">
+              <Parameter id="e082099f-7383-4e16-983e-280cfa2efee7" name="pKa_pH_WS_int_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="db40645b-7dfe-4e4c-9d37-a5458452c047">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -4407,8 +4624,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="9aab130a-b60e-49bb-ac5e-db5e539a2ed8" name="pKa_pH_WS_int_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="cddd91d6-9edc-4f32-a5a9-9004e83c7fea">
+              <Parameter id="b961a692-9a9f-4a03-a3d9-26324e7cacf7" name="pKa_pH_WS_int_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="42feb18c-4b45-435c-bfca-f100af8aa488">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -4417,8 +4635,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="76123efc-8e26-497c-be10-0e0e6619716a" name="pKa_pH_WS_int_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="ad7f267d-916e-4660-aedd-5cef24eec762">
+              <Parameter id="0a29cd42-86b9-41b9-abb2-54d161788aa4" name="pKa_pH_WS_int_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="892ffb15-bda8-49ed-8800-d000f131d888">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -4427,8 +4646,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="dd796e82-c752-4521-8abf-438b5ff623b4" name="pKa_pH_WS_int_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="0f1f3493-2a8c-435d-a761-91ed5d2ef63d">
+              <Parameter id="fb10b6a9-2d7c-4a52-9c3a-eaf1ed9d5da4" name="pKa_pH_WS_int_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="9fecb454-9dda-4079-8f94-41aa2ef8b01a">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -4437,8 +4657,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="bf8cb411-800a-41fa-bedf-f8caa2f70986" name="pKa_pH_WS_int_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="76dcb7f7-9355-4537-831b-c80a3ccec3b0">
+              <Parameter id="209d2083-f6d7-4484-82b3-950c39a73181" name="pKa_pH_WS_int_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="9acf9c22-d5c4-43cc-bb9c-b901eba3da05">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -4447,8 +4668,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="5a86d15c-352e-483c-a18d-39e5e57912d3" name="pKa_pH_WS_int_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="7b00ae87-a6d2-4d33-9d14-19ecefa12af2">
+              <Parameter id="6256e432-a3df-47a7-b729-9a493549818a" name="pKa_pH_WS_int_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="49e15e75-4920-4548-b4ad-cda235e422b6">
                 <Info min="0" max="1" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -4459,7 +4681,7 @@
           </HelpParameters>
           <FormulaCache>
             <Formulas>
-              <Formula id="07d54096-8fbd-45a7-9963-13fce294e4fa" name="PARAM_pKa_pH_WS_bc_F1" formula="CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1">
+              <Formula id="1eb54f10-3c33-44cf-965a-d81550882807" name="PARAM_pKa_pH_WS_bc_F1" formula="CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1">
                 <Paths>
                   <Path path="2" as="3" />
                   <Path path="52" as="53" />
@@ -4467,7 +4689,7 @@
                   <Path path="56" as="57" />
                 </Paths>
               </Formula>
-              <Formula id="ff3116ab-b1d1-474d-8282-f3f63ea9fbae" name="PARAM_pKa_pH_WS_bc_F2" formula="CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1">
+              <Formula id="85e4d339-33f6-4c77-b4fc-f9dc5aa0f279" name="PARAM_pKa_pH_WS_bc_F2" formula="CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1">
                 <Paths>
                   <Path path="4" as="5" />
                   <Path path="52" as="53" />
@@ -4475,7 +4697,7 @@
                   <Path path="56" as="57" />
                 </Paths>
               </Formula>
-              <Formula id="37ea14ba-0612-4be5-8a86-4f9c678b275c" name="PARAM_pKa_pH_WS_bc_F3" formula="CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1">
+              <Formula id="9e20a8b0-bc48-4dfc-8a89-fbe71e583d40" name="PARAM_pKa_pH_WS_bc_F3" formula="CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1">
                 <Paths>
                   <Path path="6" as="7" />
                   <Path path="52" as="53" />
@@ -4483,63 +4705,63 @@
                   <Path path="56" as="57" />
                 </Paths>
               </Formula>
-              <Formula id="d5af835f-c53c-4b14-95c4-8ce852fdcedb" name="PARAM_pKa_pH_WS_bc_K1" formula="F1*F2*F3">
+              <Formula id="7445e756-c254-4e40-91fc-bffd5cc0aec6" name="PARAM_pKa_pH_WS_bc_K1" formula="F1*F2*F3">
                 <Paths>
                   <Path path="62" as="63" />
                   <Path path="64" as="65" />
                   <Path path="66" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="9edf4a8d-a210-4565-be16-be03588f1a2d" name="PARAM_pKa_pH_WS_bc_K2" formula="(1-F1)*F2*F3">
+              <Formula id="98431dff-5b74-4cde-8d61-ec87e2314f90" name="PARAM_pKa_pH_WS_bc_K2" formula="(1-F1)*F2*F3">
                 <Paths>
                   <Path path="62" as="63" />
                   <Path path="64" as="65" />
                   <Path path="66" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="7a519457-d1d9-4e3e-91d6-de090c4b2cbf" name="PARAM_pKa_pH_WS_bc_K3" formula="F1*(1-F2)*F3">
+              <Formula id="4bc7b2c7-83ab-49f7-835d-84a80d7b6a3e" name="PARAM_pKa_pH_WS_bc_K3" formula="F1*(1-F2)*F3">
                 <Paths>
                   <Path path="62" as="63" />
                   <Path path="64" as="65" />
                   <Path path="66" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="4ea19b3d-2df7-4657-a54f-da661ed0d030" name="PARAM_pKa_pH_WS_bc_K4" formula="F1*F2*(1-F3)">
+              <Formula id="8196b10b-6cbb-4d7b-9c8f-2cc7ea07d008" name="PARAM_pKa_pH_WS_bc_K4" formula="F1*F2*(1-F3)">
                 <Paths>
                   <Path path="62" as="63" />
                   <Path path="64" as="65" />
                   <Path path="66" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="6a3de140-da6a-4ccf-a7dd-acd87bb7b41c" name="PARAM_pKa_pH_WS_bc_K5" formula="(1-F1)*(1-F2)*F3">
+              <Formula id="c69a4a1a-be63-4cd9-b8a7-5f6ec57792a8" name="PARAM_pKa_pH_WS_bc_K5" formula="(1-F1)*(1-F2)*F3">
                 <Paths>
                   <Path path="62" as="63" />
                   <Path path="64" as="65" />
                   <Path path="66" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="3fbea912-f66c-45b0-986a-a51fbd3d6b77" name="PARAM_pKa_pH_WS_bc_K6" formula="(1-F1)*F2*(1-F3)">
+              <Formula id="523159b1-3144-4735-bbc8-368f796cda10" name="PARAM_pKa_pH_WS_bc_K6" formula="(1-F1)*F2*(1-F3)">
                 <Paths>
                   <Path path="62" as="63" />
                   <Path path="64" as="65" />
                   <Path path="66" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="a78b888b-fed8-4eb8-93f9-1cedab164acc" name="PARAM_pKa_pH_WS_bc_K7" formula="F1*(1-F2)*(1-F3)">
+              <Formula id="12a17054-ba4b-41c3-ad26-69740ce5596a" name="PARAM_pKa_pH_WS_bc_K7" formula="F1*(1-F2)*(1-F3)">
                 <Paths>
                   <Path path="62" as="63" />
                   <Path path="64" as="65" />
                   <Path path="66" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="a5ecc09e-8984-4a2d-93f0-a3d3b9af7c20" name="PARAM_pKa_pH_WS_bc_K8" formula="(1-F1)*(1-F2)*(1-F3)">
+              <Formula id="e5908b33-2cf6-4188-b943-ec93fb3a320e" name="PARAM_pKa_pH_WS_bc_K8" formula="(1-F1)*(1-F2)*(1-F3)">
                 <Paths>
                   <Path path="62" as="63" />
                   <Path path="64" as="65" />
                   <Path path="66" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="b61d37db-4bdd-4343-8909-ffe45a5743e2" name="PARAM_pKa_pH_WS_pls_F1" formula="CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1">
+              <Formula id="04a2a4c0-0ef1-4d15-84a1-44266d32255e" name="PARAM_pKa_pH_WS_pls_F1" formula="CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1">
                 <Paths>
                   <Path path="2" as="3" />
                   <Path path="52" as="53" />
@@ -4547,7 +4769,7 @@
                   <Path path="68" as="57" />
                 </Paths>
               </Formula>
-              <Formula id="37e83663-b314-411d-8ca2-2e9781a526f7" name="PARAM_pKa_pH_WS_pls_F2" formula="CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1">
+              <Formula id="f2ee8aba-4f45-4666-8dd6-f47819e7b2b8" name="PARAM_pKa_pH_WS_pls_F2" formula="CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1">
                 <Paths>
                   <Path path="4" as="5" />
                   <Path path="52" as="53" />
@@ -4555,7 +4777,7 @@
                   <Path path="68" as="57" />
                 </Paths>
               </Formula>
-              <Formula id="d78db17c-e7d2-4c14-aa32-379f115b35d4" name="PARAM_pKa_pH_WS_pls_F3" formula="CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1">
+              <Formula id="bf0bc6b2-f48f-411d-91f9-dc512a14d691" name="PARAM_pKa_pH_WS_pls_F3" formula="CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1">
                 <Paths>
                   <Path path="6" as="7" />
                   <Path path="52" as="53" />
@@ -4563,63 +4785,63 @@
                   <Path path="68" as="57" />
                 </Paths>
               </Formula>
-              <Formula id="6587810f-e5cc-4244-bf02-29ddded3a401" name="PARAM_pKa_pH_WS_pls_K1" formula="F1*F2*F3">
+              <Formula id="d264fa00-23ab-4bf6-9703-f4f5ebf9a592" name="PARAM_pKa_pH_WS_pls_K1" formula="F1*F2*F3">
                 <Paths>
                   <Path path="69" as="63" />
                   <Path path="70" as="65" />
                   <Path path="71" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="83a7b332-9024-455d-a897-506971f78c9e" name="PARAM_pKa_pH_WS_pls_K2" formula="(1-F1)*F2*F3">
+              <Formula id="e3104349-0bfe-404c-be29-9be6de751318" name="PARAM_pKa_pH_WS_pls_K2" formula="(1-F1)*F2*F3">
                 <Paths>
                   <Path path="69" as="63" />
                   <Path path="70" as="65" />
                   <Path path="71" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="0574df10-3196-4539-8a73-2d1d18be3db6" name="PARAM_pKa_pH_WS_pls_K3" formula="F1*(1-F2)*F3">
+              <Formula id="4258d042-d4a4-47aa-9bb8-510e22b89c29" name="PARAM_pKa_pH_WS_pls_K3" formula="F1*(1-F2)*F3">
                 <Paths>
                   <Path path="69" as="63" />
                   <Path path="70" as="65" />
                   <Path path="71" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="c09ccbd1-09a4-484e-b75c-c85f5b3bbde0" name="PARAM_pKa_pH_WS_pls_K4" formula="F1*F2*(1-F3)">
+              <Formula id="6392e0d7-a4a5-46f3-b268-40bae4cd8176" name="PARAM_pKa_pH_WS_pls_K4" formula="F1*F2*(1-F3)">
                 <Paths>
                   <Path path="69" as="63" />
                   <Path path="70" as="65" />
                   <Path path="71" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="6c54588e-4137-4397-bbcc-bb6bde3d3282" name="PARAM_pKa_pH_WS_pls_K5" formula="(1-F1)*(1-F2)*F3">
+              <Formula id="945ca29f-981e-4a05-b5a2-2e815ec2d7a7" name="PARAM_pKa_pH_WS_pls_K5" formula="(1-F1)*(1-F2)*F3">
                 <Paths>
                   <Path path="69" as="63" />
                   <Path path="70" as="65" />
                   <Path path="71" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="c046e1ab-7b25-426e-b4fc-80b08343ec99" name="PARAM_pKa_pH_WS_pls_K6" formula="(1-F1)*F2*(1-F3)">
+              <Formula id="a6d1f674-70ad-4ed1-9bfc-51a53757e2fe" name="PARAM_pKa_pH_WS_pls_K6" formula="(1-F1)*F2*(1-F3)">
                 <Paths>
                   <Path path="69" as="63" />
                   <Path path="70" as="65" />
                   <Path path="71" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="6aa97393-b850-4918-9254-026fadc0ac2a" name="PARAM_pKa_pH_WS_pls_K7" formula="F1*(1-F2)*(1-F3)">
+              <Formula id="57729100-d5be-4bbb-bce4-a1345096366d" name="PARAM_pKa_pH_WS_pls_K7" formula="F1*(1-F2)*(1-F3)">
                 <Paths>
                   <Path path="69" as="63" />
                   <Path path="70" as="65" />
                   <Path path="71" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="2fbd5b94-d2da-4636-96c3-54e9f0f09118" name="PARAM_pKa_pH_WS_pls_K8" formula="(1-F1)*(1-F2)*(1-F3)">
+              <Formula id="7faf243d-c517-49a2-bd53-a78309cf0f1c" name="PARAM_pKa_pH_WS_pls_K8" formula="(1-F1)*(1-F2)*(1-F3)">
                 <Paths>
                   <Path path="69" as="63" />
                   <Path path="70" as="65" />
                   <Path path="71" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="9318f6d8-475b-4a6d-bdd7-d2951d8928ff" name="PARAM_pKa_pH_WS_cell_F1" formula="CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1">
+              <Formula id="e4740e10-cb67-4c02-a76a-9a41e8b7398c" name="PARAM_pKa_pH_WS_cell_F1" formula="CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1">
                 <Paths>
                   <Path path="72" as="57" />
                   <Path path="41" as="3" />
@@ -4627,7 +4849,7 @@
                   <Path path="74" as="55" />
                 </Paths>
               </Formula>
-              <Formula id="f1569433-7063-453d-9a69-6574005ed293" name="PARAM_pKa_pH_WS_cell_F2" formula="CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1">
+              <Formula id="13026517-1df0-4543-98ff-c996a3efcfbf" name="PARAM_pKa_pH_WS_cell_F2" formula="CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1">
                 <Paths>
                   <Path path="72" as="57" />
                   <Path path="42" as="5" />
@@ -4635,7 +4857,7 @@
                   <Path path="75" as="59" />
                 </Paths>
               </Formula>
-              <Formula id="99a8f98c-3af3-4b33-9d64-3d4b7ef1a75d" name="PARAM_pKa_pH_WS_cell_F3" formula="CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1">
+              <Formula id="54c3a25f-cda4-4967-881a-5f76a785e4e4" name="PARAM_pKa_pH_WS_cell_F3" formula="CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1">
                 <Paths>
                   <Path path="72" as="57" />
                   <Path path="43" as="7" />
@@ -4643,63 +4865,63 @@
                   <Path path="76" as="61" />
                 </Paths>
               </Formula>
-              <Formula id="c8d3983f-9287-4f28-9c9e-56a54b45682b" name="PARAM_pKa_pH_WS_cell_K1" formula="F1*F2*F3">
+              <Formula id="501fabd0-eab2-49c8-9ead-49fe7cafaeb0" name="PARAM_pKa_pH_WS_cell_K1" formula="F1*F2*F3">
                 <Paths>
                   <Path path="77" as="63" />
                   <Path path="78" as="65" />
                   <Path path="79" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="08f04380-7221-4d5f-8309-b0eb653b9618" name="PARAM_pKa_pH_WS_cell_K2" formula="(1-F1)*F2*F3">
+              <Formula id="0dc082de-0bc8-4c5a-a101-eabca41f8d2d" name="PARAM_pKa_pH_WS_cell_K2" formula="(1-F1)*F2*F3">
                 <Paths>
                   <Path path="77" as="63" />
                   <Path path="78" as="65" />
                   <Path path="79" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="eb4899b7-e220-4321-b54f-a49c072c0d49" name="PARAM_pKa_pH_WS_cell_K3" formula="F1*(1-F2)*F3">
+              <Formula id="6e1cfa69-69d1-4183-ab0f-b3ac569c3836" name="PARAM_pKa_pH_WS_cell_K3" formula="F1*(1-F2)*F3">
                 <Paths>
                   <Path path="77" as="63" />
                   <Path path="78" as="65" />
                   <Path path="79" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="2737fddb-030e-4c03-bce4-fa951906d4ab" name="PARAM_pKa_pH_WS_cell_K4" formula="F1*F2*(1-F3)">
+              <Formula id="947632fb-e711-44c5-9722-299cd270cd01" name="PARAM_pKa_pH_WS_cell_K4" formula="F1*F2*(1-F3)">
                 <Paths>
                   <Path path="77" as="63" />
                   <Path path="78" as="65" />
                   <Path path="79" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="30d65357-2555-4608-9e4d-2ab162b27e15" name="PARAM_pKa_pH_WS_cell_K5" formula="(1-F1)*(1-F2)*F3">
+              <Formula id="f6a37965-1702-4466-832e-12d95f1e6f19" name="PARAM_pKa_pH_WS_cell_K5" formula="(1-F1)*(1-F2)*F3">
                 <Paths>
                   <Path path="77" as="63" />
                   <Path path="78" as="65" />
                   <Path path="79" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="feb4a455-9a9f-4ff6-852b-45b49446ad74" name="PARAM_pKa_pH_WS_cell_K6" formula="(1-F1)*F2*(1-F3)">
+              <Formula id="830b000e-2f04-45d2-9771-76a35e17b793" name="PARAM_pKa_pH_WS_cell_K6" formula="(1-F1)*F2*(1-F3)">
                 <Paths>
                   <Path path="77" as="63" />
                   <Path path="78" as="65" />
                   <Path path="79" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="79e90f49-0ccd-4bdb-b075-43c8fd658daa" name="PARAM_pKa_pH_WS_cell_K7" formula="F1*(1-F2)*(1-F3)">
+              <Formula id="ce676edc-b757-4d25-b115-14a562324351" name="PARAM_pKa_pH_WS_cell_K7" formula="F1*(1-F2)*(1-F3)">
                 <Paths>
                   <Path path="77" as="63" />
                   <Path path="78" as="65" />
                   <Path path="79" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="81c8ceed-60d3-49af-a61d-6e3923e8b625" name="PARAM_pKa_pH_WS_cell_K8" formula="(1-F1)*(1-F2)*(1-F3)">
+              <Formula id="17a55d76-3026-41fb-81e8-ad709687ed88" name="PARAM_pKa_pH_WS_cell_K8" formula="(1-F1)*(1-F2)*(1-F3)">
                 <Paths>
                   <Path path="77" as="63" />
                   <Path path="78" as="65" />
                   <Path path="79" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="f73eadfe-d500-45dd-bb21-1b76b9ed2759" name="PARAM_pKa_pH_WS_int_F1" formula="CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1">
+              <Formula id="cffc4024-623f-426d-8528-7ba78f715cc3" name="PARAM_pKa_pH_WS_int_F1" formula="CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1">
                 <Paths>
                   <Path path="80" as="57" />
                   <Path path="41" as="3" />
@@ -4707,7 +4929,7 @@
                   <Path path="74" as="55" />
                 </Paths>
               </Formula>
-              <Formula id="d026189c-1fb9-4a37-8e8c-f4c32ab1a372" name="PARAM_pKa_pH_WS_int_F2" formula="CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1">
+              <Formula id="784e3399-9fa1-458a-8765-20ca486d501d" name="PARAM_pKa_pH_WS_int_F2" formula="CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1">
                 <Paths>
                   <Path path="80" as="57" />
                   <Path path="42" as="5" />
@@ -4715,7 +4937,7 @@
                   <Path path="75" as="59" />
                 </Paths>
               </Formula>
-              <Formula id="ce122b40-985f-4d0d-8447-ddc0a2341da4" name="PARAM_pKa_pH_WS_int_F3" formula="CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1">
+              <Formula id="f1f48185-b04a-4b6d-bb80-fe69b88045c6" name="PARAM_pKa_pH_WS_int_F3" formula="CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1">
                 <Paths>
                   <Path path="80" as="57" />
                   <Path path="43" as="7" />
@@ -4723,56 +4945,56 @@
                   <Path path="76" as="61" />
                 </Paths>
               </Formula>
-              <Formula id="b9495cbd-90e9-493d-beca-87a403200b4d" name="PARAM_pKa_pH_WS_int_K1" formula="F1*F2*F3">
+              <Formula id="44b91625-71e6-47a5-b62a-88837fefdfc3" name="PARAM_pKa_pH_WS_int_K1" formula="F1*F2*F3">
                 <Paths>
                   <Path path="81" as="63" />
                   <Path path="82" as="65" />
                   <Path path="83" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="0e7d9d3a-8f58-4466-905f-0de1f72ef361" name="PARAM_pKa_pH_WS_int_K2" formula="(1-F1)*F2*F3">
+              <Formula id="22516428-e9d5-4d51-8fde-20831ab6262c" name="PARAM_pKa_pH_WS_int_K2" formula="(1-F1)*F2*F3">
                 <Paths>
                   <Path path="81" as="63" />
                   <Path path="82" as="65" />
                   <Path path="83" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="c16e69e3-92a8-4773-aa2c-155446cad03c" name="PARAM_pKa_pH_WS_int_K3" formula="F1*(1-F2)*F3">
+              <Formula id="db40645b-7dfe-4e4c-9d37-a5458452c047" name="PARAM_pKa_pH_WS_int_K3" formula="F1*(1-F2)*F3">
                 <Paths>
                   <Path path="81" as="63" />
                   <Path path="82" as="65" />
                   <Path path="83" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="cddd91d6-9edc-4f32-a5a9-9004e83c7fea" name="PARAM_pKa_pH_WS_int_K4" formula="F1*F2*(1-F3)">
+              <Formula id="42feb18c-4b45-435c-bfca-f100af8aa488" name="PARAM_pKa_pH_WS_int_K4" formula="F1*F2*(1-F3)">
                 <Paths>
                   <Path path="81" as="63" />
                   <Path path="82" as="65" />
                   <Path path="83" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="ad7f267d-916e-4660-aedd-5cef24eec762" name="PARAM_pKa_pH_WS_int_K5" formula="(1-F1)*(1-F2)*F3">
+              <Formula id="892ffb15-bda8-49ed-8800-d000f131d888" name="PARAM_pKa_pH_WS_int_K5" formula="(1-F1)*(1-F2)*F3">
                 <Paths>
                   <Path path="81" as="63" />
                   <Path path="82" as="65" />
                   <Path path="83" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="0f1f3493-2a8c-435d-a761-91ed5d2ef63d" name="PARAM_pKa_pH_WS_int_K6" formula="(1-F1)*F2*(1-F3)">
+              <Formula id="9fecb454-9dda-4079-8f94-41aa2ef8b01a" name="PARAM_pKa_pH_WS_int_K6" formula="(1-F1)*F2*(1-F3)">
                 <Paths>
                   <Path path="81" as="63" />
                   <Path path="82" as="65" />
                   <Path path="83" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="76dcb7f7-9355-4537-831b-c80a3ccec3b0" name="PARAM_pKa_pH_WS_int_K7" formula="F1*(1-F2)*(1-F3)">
+              <Formula id="9acf9c22-d5c4-43cc-bb9c-b901eba3da05" name="PARAM_pKa_pH_WS_int_K7" formula="F1*(1-F2)*(1-F3)">
                 <Paths>
                   <Path path="81" as="63" />
                   <Path path="82" as="65" />
                   <Path path="83" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="7b00ae87-a6d2-4d33-9d14-19ecefa12af2" name="PARAM_pKa_pH_WS_int_K8" formula="(1-F1)*(1-F2)*(1-F3)">
+              <Formula id="49e15e75-4920-4548-b4ad-cda235e422b6" name="PARAM_pKa_pH_WS_int_K8" formula="(1-F1)*(1-F2)*(1-F3)">
                 <Paths>
                   <Path path="81" as="63" />
                   <Path path="82" as="65" />
@@ -4868,10 +5090,11 @@
             </StringMap>
           </FormulaCache>
         </CoreCalculationMethod>
-        <CoreCalculationMethod id="6bb3994b-8f3a-4525-aeef-8446c5167dbe" name="Interstitial partition coefficient method - Schmitt" icon="CoreCalculationMethod" bbVersion="0" category="DistributionInterstitial">
+        <CoreCalculationMethod id="40df6e05-5447-4304-bcac-c37afd615b21" name="Interstitial partition coefficient method - Schmitt" icon="CoreCalculationMethod" bbVersion="0" category="DistributionInterstitial">
+          <Creation createdAt="5248846165144708870" createdBy="Michael" creationMode="New" origin="Other" />
           <OutputFormulas>
             <KeyValue>
-              <Formula id="951d5fa7-b755-45e5-95a5-c9efb680c757" name="PARAM_K_int_pls" formula="(f_water_int + f_proteins_int_to_pls * (1/fu - f_water_pls)) * fu">
+              <Formula id="029ed8ef-f79d-46b7-8f4d-13b045bd6e46" name="PARAM_K_int_pls" formula="(f_water_int + f_proteins_int_to_pls * (1/fu - f_water_pls)) * fu">
                 <Paths>
                   <Path path="0" as="1" dim="2" />
                   <Path path="3" as="4" />
@@ -4890,8 +5113,9 @@
           </OutputFormulas>
           <HelpParameters>
             <KeyValue>
-              <Parameter id="9c21d23c-5e62-416b-b99b-b22330841653" name="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="a700477a-b94c-4770-a2e6-4a1b53d8b775">
+              <Parameter id="9245a76b-6a87-4b5a-ac27-04694b4cd8a5" name="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="31f9aa07-1dfc-4c20-acc4-f915c7de38d1">
                 <Info min="0" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -4900,8 +5124,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="61a1ccc0-ee2c-4774-a4cd-7be90ebfa96d" name="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="e986f742-2a5f-4be4-bd5f-a7821eba69b4">
+              <Parameter id="63041ff4-8981-449c-8787-98ef519d53f3" name="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="0b88a07e-bd89-4b83-9f7f-30142e1f79bf">
                 <Info min="0" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -4910,8 +5135,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="63cac38e-88bc-490e-a9f4-0a036f94c9be" name="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="3e9f9ad3-044d-4c26-8ccd-edc78619c7a7">
+              <Parameter id="05eaf150-3369-4fe2-bc3e-c44cdc048b39" name="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="254ea20c-5831-4119-836c-9626ce2f483a">
                 <Info min="0" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -4920,8 +5146,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="84180175-71f8-4c66-ba06-daeea6b651b4" name="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="7b57f883-1313-4cde-a8c8-d17e5d8d34aa">
+              <Parameter id="b91b9000-58f9-4060-a22f-a8a4c2a000b7" name="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="3b768ca4-5629-42bd-b0d8-486653f0e501">
                 <Info min="0" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -4930,8 +5157,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="45a1e938-ac15-4413-900b-ce3052742fd2" name="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="e1fa00f3-bdf8-4169-b265-0600b379b780">
+              <Parameter id="a5fd3d32-93c4-4b38-a38f-887894a28c2b" name="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="f2919d10-c898-4ebb-a130-ede30aaffc16">
                 <Info min="0" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -4940,8 +5168,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="7fbd1614-1c25-4afc-9a60-35a708da45c1" name="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="7ab13880-fd9e-4e1a-8bee-2d319a098423">
+              <Parameter id="8e97ca45-ad1a-4b03-b07a-6999762f47e2" name="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="5891aca0-c80d-4188-8885-1475b2cff296">
                 <Info min="0" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -4951,8 +5180,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="5b525007-a787-4c7b-9728-ccc75070ea27" name="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="0239a212-506d-429f-91a4-1421d3388f27">
+              <Parameter id="d65fe75d-b2a1-4f50-a44c-c7e61614a431" name="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="243a8237-95a5-4cb3-b2b4-00a7619752ee">
                 <Info min="0" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -4961,8 +5191,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="a3614239-a561-4351-b3fa-c9e32598b773" name="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="7a228734-0818-4e7a-abb9-fe976ad740e8">
+              <Parameter id="0657db45-dbd3-4e5d-b39c-c0f0f0b82561" name="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="e5871f6a-37e4-450f-a583-3bb16b23e5b9">
                 <Info min="0" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -4971,8 +5202,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="ff29d23d-7121-472b-a537-85fa5dd9296e" name="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="b3b810ab-f34a-42ff-8b5e-e67000b27123">
+              <Parameter id="a9800c07-4621-4354-9a28-5644a8ebf8e1" name="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="13f706e7-f0e5-452c-a3c3-f8abe95a0754">
                 <Info min="0" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -4981,8 +5213,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="c2c2a487-64f3-4847-a4fe-679385f48dd6" name="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="88b8d08e-51eb-4483-9c3f-8e4c234e6e79">
+              <Parameter id="f554ea56-03c5-4b6a-a927-f683898f8af3" name="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="94f0f428-8ec9-4af1-8568-2a0d98c9745b">
                 <Info min="0" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -4991,8 +5224,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="b0e31e24-31d8-40ab-93ba-dc68c5db8e13" name="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="7ef8530e-36db-4ad4-9e11-9b6625709ff0">
+              <Parameter id="e595e907-adf2-47fa-90b3-e1a9c6f067cf" name="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="5b5cf8b8-fa30-4078-b8a9-40cd4e49aca9">
                 <Info min="0" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -5002,8 +5236,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="fe113f8d-781d-41cb-abc2-71aec8cc251e" name="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="75570cc5-81b8-4dca-9824-48232df854da">
+              <Parameter id="9e90598e-67f2-4717-bfd5-bbe4aab7bdfb" name="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="e26404db-6676-4712-a75b-b25ccc962a11">
                 <Info min="0" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -5012,8 +5247,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="ce8e96d8-097f-4d47-a44a-1d4e83c69158" name="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="9ba12a44-a49e-4540-8255-fcbe8016fb01">
+              <Parameter id="1ec2a166-ec43-49bf-8dcf-60949a0d010e" name="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="fc249621-a771-47e9-a53c-db03b1727a07">
                 <Info min="0" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
@@ -5022,8 +5258,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="f204c7e7-d3f3-4933-822b-3fa110e5a181" name="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="72a91071-0eab-4a41-a868-8d129e728ebd">
+              <Parameter id="4456fbf8-026d-438e-9713-0e2c3392c644" name="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="26293535-5dcd-4295-9b7e-f39f36aa77a8">
                 <Info min="0" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
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               <DescriptorCriteria>
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@@ -5032,8 +5269,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="8e489756-47bb-4d14-926c-3fe67ffe286f" name="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="5056215e-6082-4092-9390-cdc53fc1b843">
+              <Parameter id="07ef5844-b4fb-4ce3-bba6-da77344870d7" name="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="294e17c6-54a6-48ae-872a-7332cd7613db">
                 <Info min="0" flag="52" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
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               <DescriptorCriteria>
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@@ -5041,131 +5279,99 @@
                 </DescriptorConditions>
               </DescriptorCriteria>
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-            <KeyValue>
-              <Parameter id="48b9ea7b-61fa-42d2-b63c-309307ad5733" name="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="04794a05-d2de-4d16-8a54-f6191167ad00">
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-              <DescriptorCriteria>
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-                  <MatchTagCondition tag="Periportal_int_Periportal_cell" />
-                </DescriptorConditions>
-              </DescriptorCriteria>
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-            <KeyValue>
-              <Parameter id="1b73ede1-cabc-4841-829e-92a4723cf50f" name="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="9b4736a5-08f6-4ae3-8e93-ded226aa283d">
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-              <DescriptorCriteria>
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-                  <MatchTagCondition tag="Pericentral_int_Pericentral_cell" />
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-              </DescriptorCriteria>
-            </KeyValue>
           </HelpParameters>
           <FormulaCache>
             <Formulas>
-              <Formula id="a700477a-b94c-4770-a2e6-4a1b53d8b775" name="PARAM_K_water_int_bon_Schmitt" formula="fu/K_int_pls">
+              <Formula id="31f9aa07-1dfc-4c20-acc4-f915c7de38d1" name="PARAM_K_water_int_bon_Schmitt" formula="fu/K_int_pls">
                 <Paths>
                   <Path path="0" as="1" dim="2" />
                   <Path path="9" as="10" />
                 </Paths>
               </Formula>
-              <Formula id="e986f742-2a5f-4be4-bd5f-a7821eba69b4" name="PARAM_K_water_int_brn_Schmitt" formula="fu/K_int_pls">
+              <Formula id="0b88a07e-bd89-4b83-9f7f-30142e1f79bf" name="PARAM_K_water_int_brn_Schmitt" formula="fu/K_int_pls">
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                   <Path path="11" as="10" />
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-              <Formula id="3e9f9ad3-044d-4c26-8ccd-edc78619c7a7" name="PARAM_K_water_int_fat_Schmitt" formula="fu/K_int_pls">
+              <Formula id="254ea20c-5831-4119-836c-9626ce2f483a" name="PARAM_K_water_int_fat_Schmitt" formula="fu/K_int_pls">
                 <Paths>
                   <Path path="0" as="1" dim="2" />
                   <Path path="12" as="10" />
                 </Paths>
               </Formula>
-              <Formula id="7b57f883-1313-4cde-a8c8-d17e5d8d34aa" name="PARAM_K_water_int_hrt_Schmitt" formula="fu/K_int_pls">
+              <Formula id="3b768ca4-5629-42bd-b0d8-486653f0e501" name="PARAM_K_water_int_hrt_Schmitt" formula="fu/K_int_pls">
                 <Paths>
                   <Path path="0" as="1" dim="2" />
                   <Path path="13" as="10" />
                 </Paths>
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-              <Formula id="e1fa00f3-bdf8-4169-b265-0600b379b780" name="PARAM_K_water_int_kid_Schmitt" formula="fu/K_int_pls">
+              <Formula id="f2919d10-c898-4ebb-a130-ede30aaffc16" name="PARAM_K_water_int_kid_Schmitt" formula="fu/K_int_pls">
                 <Paths>
                   <Path path="0" as="1" dim="2" />
                   <Path path="14" as="10" />
                 </Paths>
               </Formula>
-              <Formula id="7ab13880-fd9e-4e1a-8bee-2d319a098423" name="PARAM_K_water_int_lin_Schmitt" formula="fu/K_int_pls">
+              <Formula id="5891aca0-c80d-4188-8885-1475b2cff296" name="PARAM_K_water_int_lin_Schmitt" formula="fu/K_int_pls">
                 <Paths>
                   <Path path="0" as="1" dim="2" />
                   <Path path="15" as="10" />
                 </Paths>
               </Formula>
-              <Formula id="0239a212-506d-429f-91a4-1421d3388f27" name="PARAM_K_water_int_liv_Schmitt" formula="fu/K_int_pls">
+              <Formula id="243a8237-95a5-4cb3-b2b4-00a7619752ee" name="PARAM_K_water_int_liv_Schmitt" formula="fu/K_int_pls">
                 <Paths>
                   <Path path="0" as="1" dim="2" />
                   <Path path="16" as="10" />
                 </Paths>
               </Formula>
-              <Formula id="7a228734-0818-4e7a-abb9-fe976ad740e8" name="PARAM_K_water_int_lng_Schmitt" formula="fu/K_int_pls">
+              <Formula id="e5871f6a-37e4-450f-a583-3bb16b23e5b9" name="PARAM_K_water_int_lng_Schmitt" formula="fu/K_int_pls">
                 <Paths>
                   <Path path="0" as="1" dim="2" />
                   <Path path="17" as="10" />
                 </Paths>
               </Formula>
-              <Formula id="b3b810ab-f34a-42ff-8b5e-e67000b27123" name="PARAM_K_water_int_mus_Schmitt" formula="fu/K_int_pls">
+              <Formula id="13f706e7-f0e5-452c-a3c3-f8abe95a0754" name="PARAM_K_water_int_mus_Schmitt" formula="fu/K_int_pls">
                 <Paths>
                   <Path path="0" as="1" dim="2" />
                   <Path path="18" as="10" />
                 </Paths>
               </Formula>
-              <Formula id="88b8d08e-51eb-4483-9c3f-8e4c234e6e79" name="PARAM_K_water_int_pan_Schmitt" formula="fu/K_int_pls">
+              <Formula id="94f0f428-8ec9-4af1-8568-2a0d98c9745b" name="PARAM_K_water_int_pan_Schmitt" formula="fu/K_int_pls">
                 <Paths>
                   <Path path="0" as="1" dim="2" />
                   <Path path="19" as="10" />
                 </Paths>
               </Formula>
-              <Formula id="7ef8530e-36db-4ad4-9e11-9b6625709ff0" name="PARAM_K_water_int_sin_Schmitt" formula="fu/K_int_pls">
+              <Formula id="5b5cf8b8-fa30-4078-b8a9-40cd4e49aca9" name="PARAM_K_water_int_sin_Schmitt" formula="fu/K_int_pls">
                 <Paths>
                   <Path path="0" as="1" dim="2" />
                   <Path path="20" as="10" />
                 </Paths>
               </Formula>
-              <Formula id="75570cc5-81b8-4dca-9824-48232df854da" name="PARAM_K_water_int_skn_Schmitt" formula="fu/K_int_pls">
+              <Formula id="e26404db-6676-4712-a75b-b25ccc962a11" name="PARAM_K_water_int_skn_Schmitt" formula="fu/K_int_pls">
                 <Paths>
                   <Path path="0" as="1" dim="2" />
                   <Path path="21" as="10" />
                 </Paths>
               </Formula>
-              <Formula id="9ba12a44-a49e-4540-8255-fcbe8016fb01" name="PARAM_K_water_int_spl_Schmitt" formula="fu/K_int_pls">
+              <Formula id="fc249621-a771-47e9-a53c-db03b1727a07" name="PARAM_K_water_int_spl_Schmitt" formula="fu/K_int_pls">
                 <Paths>
                   <Path path="0" as="1" dim="2" />
                   <Path path="22" as="10" />
                 </Paths>
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-              <Formula id="72a91071-0eab-4a41-a868-8d129e728ebd" name="PARAM_K_water_int_sto_Schmitt" formula="fu/K_int_pls">
+              <Formula id="26293535-5dcd-4295-9b7e-f39f36aa77a8" name="PARAM_K_water_int_sto_Schmitt" formula="fu/K_int_pls">
                 <Paths>
                   <Path path="0" as="1" dim="2" />
                   <Path path="23" as="10" />
                 </Paths>
               </Formula>
-              <Formula id="5056215e-6082-4092-9390-cdc53fc1b843" name="PARAM_K_water_int_tes_Schmitt" formula="fu/K_int_pls">
+              <Formula id="294e17c6-54a6-48ae-872a-7332cd7613db" name="PARAM_K_water_int_tes_Schmitt" formula="fu/K_int_pls">
                 <Paths>
                   <Path path="0" as="1" dim="2" />
                   <Path path="24" as="10" />
                 </Paths>
               </Formula>
-              <Formula id="04794a05-d2de-4d16-8a54-f6191167ad00" name="PARAM_K_water_prp_Schmitt" formula="fu/K_int_pls">
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-                  <Path path="25" as="10" />
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-              <Formula id="9b4736a5-08f6-4ae3-8e93-ded226aa283d" name="PARAM_K_water_prc_Schmitt" formula="fu/K_int_pls">
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-                  <Path path="26" as="10" />
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             <StringMap>
               <Map s="MOLECULE|Fraction unbound (plasma)" id="0" />
@@ -5193,191 +5399,141 @@
               <Map s="Neighborhoods|Spleen_pls_Spleen_int|MOLECULE|Partition coefficient (interstitial/plasma)" id="22" />
               <Map s="Neighborhoods|Stomach_pls_Stomach_int|MOLECULE|Partition coefficient (interstitial/plasma)" id="23" />
               <Map s="Neighborhoods|Gonads_pls_Gonads_int|MOLECULE|Partition coefficient (interstitial/plasma)" id="24" />
-              <Map s="Neighborhoods|Periportal_pls_Periportal_int|MOLECULE|Partition coefficient (interstitial/plasma)" id="25" />
-              <Map s="Neighborhoods|Pericentral_pls_Pericentral_int|MOLECULE|Partition coefficient (interstitial/plasma)" id="26" />
             </StringMap>
           </FormulaCache>
         </CoreCalculationMethod>
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-        <CoreCalculationMethod id="bb4467da-6f64-48eb-9d5b-e2e366778a0b" name="No Calculation Method" icon="CoreCalculationMethod" bbVersion="0" category="DistributionCellular">
+        <CoreCalculationMethod id="0795bad3-f11f-46ed-9246-55bc09f72c38" name="No Calculation Method" icon="CoreCalculationMethod" bbVersion="0" category="DistributionCellular">
+          <Creation createdAt="5248846165144718838" createdBy="Michael" creationMode="New" origin="Other" />
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+        <CoreCalculationMethod id="a80da387-b380-4720-bf7c-0f7b0c3fe03c" name="No Calculation Method" icon="CoreCalculationMethod" bbVersion="0" category="DiffusionIntCell">
+          <Creation createdAt="5248846165144718838" createdBy="Michael" creationMode="New" origin="Other" />
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-        <CoreCalculationMethod id="06c653de-bd40-4f2f-a3ca-c3c5fd647623" name="No Calculation Method" icon="CoreCalculationMethod" bbVersion="0" category="DistributionInterstitial">
+        <CoreCalculationMethod id="836eb942-85f7-47a6-883f-db3b02465eae" name="No Calculation Method" icon="CoreCalculationMethod" bbVersion="0" category="DistributionInterstitial">
+          <Creation createdAt="5248846165144718838" createdBy="Michael" creationMode="New" origin="Other" />
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           <HelpParameters />
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-      <Root id="be5138c0-aeb4-4283-a015-773db76199da" name="run" mode="Logical" containerType="Simulation">
+    <Model id="ab2d7062-08c6-4829-993f-ff269c4ff11d" name="run" neighborhoods="b6416842-9510-4eff-98aa-7826aed5d7d6">
+      <Root id="aba307b0-9428-4c76-b22c-e8b2e587211f" name="run" mode="Logical" containerType="Simulation">
         <Tags>
           <Tag value="RootContainer" />
         </Tags>
         <Children>
-          <Container id="8f789a66-208a-424f-adbe-8f20eaa24e3d" name="Organism" icon="ORGANISM" mode="Physical" containerType="Organism">
+          <Container id="807f68fc-9f87-4733-930d-6725be98c2d4" name="Organism" icon="ORGANISM" mode="Physical" containerType="Organism">
             <Tags>
               <Tag value="Organism" />
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+              <Parameter id="993d7b89-c654-443a-adba-79e618e0bda4" name="Volume" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" value="1" displayUnit="ml">
                 <Info flag="10" seq="1" ref="0" bb="2" group="65" />
+                <Origin />
               </Parameter>
-              <Container id="039cab00-5945-45bc-bfd9-edc95dfd777b" name="LV" icon="CONTAINER" mode="Logical" containerType="Organ">
+              <Container id="379554b1-a18b-484d-8089-0e7ad53c085e" name="LV" icon="CONTAINER" mode="Logical" containerType="Organ">
                 <Tags>
                   <Tag value="LV" />
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+                  <Parameter id="1374ed58-cdea-4ea3-9849-28a02f31093f" name="Plv" icon="Parameter" persistable="1" isFixedValue="0" dim="Pressure" quantityType="Parameter" negativeValuesAllowed="1" formula="pr2_qmAGnEiu4vEyJiktxA" displayUnit="Pa">
                     <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+                    <Origin />
                   </Parameter>
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+                  <Parameter id="e3de04ad-3877-4fe7-b75f-d242faa2e011" name="Vlv" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" rHSFormula="6Q6p4KbSykGHlcByVfZr1Q" value="0.001" displayUnit="ml">
                     <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+                    <Origin />
                   </Parameter>
-                  <Parameter id="e7ea03f6-7e0b-42e9-8396-7092fe142c72" name="Elv1" description="wave build up" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="b30c4b7f-b5ca-4126-94ca-16fafc11e5ca">
+                  <Parameter id="c814016d-81a0-4843-97df-310101464144" name="Elv1" description="wave build up" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="DqzUGgYMxkCx3bNfM-s_kw">
                     <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+                    <Origin />
                   </Parameter>
-                  <Parameter id="af088631-58b7-421d-a48f-c83b8a011e7c" name="Elv2" description="wave relaxation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="ccefa9bf-7862-47e3-aa09-aaa0f86e6b2d">
+                  <Parameter id="1d77db0c-e623-4436-8e12-c7b68c1d41c2" name="Elv2" description="wave relaxation" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="2phZA2w6RUGu6EH3VvuEsQ">
                     <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+                    <Origin />
                   </Parameter>
-                  <Parameter id="83f947d1-5789-49cd-bc51-7d4a33ba8140" name="Elv" description="Elv" icon="Parameter" persistable="1" isFixedValue="0" quantityType="Parameter" formula="6780622b-8b26-44fd-8d32-09b7b329f777">
+                  <Parameter id="7e096c42-0169-4849-b17b-d61ff6ab9c69" name="Elv" description="Elv" icon="Parameter" persistable="1" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="-hDOfQ9aWku9fj4pG0zd7w">
                     <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+                    <Origin />
                   </Parameter>
-                  <Parameter id="39569e8e-1abf-4f46-a3de-0849e5719e7d" name="Peslv" icon="Parameter" persistable="0" isFixedValue="0" dim="Pressure" quantityType="Parameter" formula="d9e5737e-02a7-4314-8a9e-a9590336c7ab" displayUnit="Pa">
+                  <Parameter id="bf6b3dee-9309-4fe7-8df5-82d6b62b04d1" name="Peslv" icon="Parameter" persistable="0" isFixedValue="0" dim="Pressure" quantityType="Parameter" negativeValuesAllowed="1" formula="8hs0Nf3WKEqO1Uyt_yrTlA" displayUnit="Pa">
                     <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+                    <Origin />
                   </Parameter>
-                  <Parameter id="c37fe4ef-bcf7-4cef-bf63-5e52c4317a6d" name="Pedlv" icon="Parameter" persistable="0" isFixedValue="0" dim="Pressure" quantityType="Parameter" formula="b37eb208-991d-43e4-9bfe-de22e7437a39" displayUnit="Pa">
+                  <Parameter id="a2c40471-aafa-4faa-8b23-6500007d8a34" name="Pedlv" icon="Parameter" persistable="0" isFixedValue="0" dim="Pressure" quantityType="Parameter" negativeValuesAllowed="1" formula="Bgkgi4D4PUO1Lh2kIawFXg" displayUnit="Pa">
                     <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+                    <Origin />
                   </Parameter>
-                  <Parameter id="049cb89e-ebe0-49ce-a629-969967f80485" name="bLV" description="valve" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="3fedf76b-7f13-478f-961e-c6ce8b6d74b2">
+                  <Parameter id="907ecfa9-9dc1-4fcd-8a64-2682d1434233" name="bLV" description="valve" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="3CQw8VUhckaAUEw1EW5IzQ">
                     <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+                    <Origin />
                   </Parameter>
-                  <Parameter id="e0fc8863-511a-4467-8e33-2c08d54af40f" name="aLV" description="valve" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" formula="f32ad3a0-9967-4517-b90e-63e7edc6aae3">
+                  <Parameter id="7908bd6b-44ce-476b-85e5-0a799d70fbea" name="aLV" description="valve" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="3tx7w0XGcUmOVJ8H6ezlnQ">
                     <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+                    <Origin />
                   </Parameter>
-                  <Parameter id="4750a1b4-7ab2-4f4b-b83d-f78a11fd6dfb" name="V0lv" description="zero ventricular pressure" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" value="0.0001" displayUnit="ml">
+                  <Parameter id="84977e03-4ce0-4e00-87f8-82af5fd3e60f" name="V0lv" description="zero ventricular pressure" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" value="0.0001" displayUnit="ml">
                     <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+                    <Origin />
                   </Parameter>
-                  <Parameter id="1fd9cac3-dbd3-4fbd-bbbe-5aad6aa8aa0f" name="Rvp" description="Rvp" icon="Parameter" persistable="0" isFixedValue="0" dim="Resistance" quantityType="Parameter" value="6000" displayUnit="Pa*s/ml">
+                  <Parameter id="f17cbea1-bdbe-4d87-bfcf-8efe7cb5fa88" name="Rvp" description="Rvp" icon="Parameter" persistable="0" isFixedValue="0" dim="Resistance" quantityType="Parameter" negativeValuesAllowed="1" value="6000" displayUnit="Pa*s/ml">
                     <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+                    <Origin />
                   </Parameter>
-                  <Parameter id="924d6ab6-ca95-4791-9428-6d538b1e32ed" name="Rcs" description="Rcs" icon="Parameter" persistable="0" isFixedValue="0" dim="Resistance" quantityType="Parameter" value="6000" displayUnit="Pa*s/ml">
+                  <Parameter id="31396434-6c5e-40c1-87e7-d9641bd61068" name="Rcs" description="Rcs" icon="Parameter" persistable="0" isFixedValue="0" dim="Resistance" quantityType="Parameter" negativeValuesAllowed="1" value="6000" displayUnit="Pa*s/ml">
                     <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+                    <Origin />
                   </Parameter>
-                  <Parameter id="1a220bd6-60de-469a-82d1-4f62ac07c03b" name="Pcvp" icon="Parameter" persistable="0" isFixedValue="0" dim="Pressure" quantityType="Parameter" value="360" displayUnit="Pa">
+                  <Parameter id="fc4dfc34-1386-4ce5-a37c-7eb672aa8df9" name="Pcvp" icon="Parameter" persistable="0" isFixedValue="0" dim="Pressure" quantityType="Parameter" negativeValuesAllowed="1" value="360" displayUnit="Pa">
                     <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+                    <Origin />
                   </Parameter>
-                  <Parameter id="9e9caeb2-d0c4-44fd-9bf9-27905921d56b" name="Pcas" icon="Parameter" persistable="0" isFixedValue="0" dim="Pressure" quantityType="Parameter" value="360" displayUnit="Pa">
+                  <Parameter id="5f731c1f-9bca-4675-a438-df6a39265794" name="Pcas" icon="Parameter" persistable="0" isFixedValue="0" dim="Pressure" quantityType="Parameter" negativeValuesAllowed="1" value="360" displayUnit="Pa">
                     <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+                    <Origin />
                   </Parameter>
-                  <Parameter id="6c31379e-6426-4b18-b2e1-387c131c96ed" name="Eeslv" icon="Parameter" persistable="0" isFixedValue="0" dim="Elastance" quantityType="Parameter" value="360000" displayUnit="Pa/ml">
+                  <Parameter id="b4fe6289-6c8f-4bbf-b12d-6d607a272ac7" name="Eeslv" icon="Parameter" persistable="0" isFixedValue="0" dim="Elastance" quantityType="Parameter" negativeValuesAllowed="1" value="360000" displayUnit="Pa/ml">
                     <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+                    <Origin />
                   </Parameter>
-                  <Parameter id="a4173139-65a1-4e71-b68c-eb32b42865b5" name="Pcp" icon="Parameter" persistable="0" isFixedValue="0" dim="Pressure" quantityType="Parameter" value="360" displayUnit="Pa">
+                  <Parameter id="27d08868-4179-45e1-909d-3c4a69cb7a44" name="Pcp" icon="Parameter" persistable="0" isFixedValue="0" dim="Pressure" quantityType="Parameter" negativeValuesAllowed="1" value="360" displayUnit="Pa">
                     <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+                    <Origin />
                   </Parameter>
                 </Children>
               </Container>
-              <Parameter id="02bcff65-696b-4835-a2af-11687a0e3656" name="Tes" description="time of pulse build up" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" value="1" displayUnit="min">
+              <Parameter id="65be65ba-737f-4e07-aed1-a25ea40ba10d" name="Tes" description="time of pulse build up" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" value="1" displayUnit="min">
                 <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
-              <Parameter id="c16d8aea-5b27-4673-a2d9-6f176446a76e" name="tau" description="time of pulse relaxation" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" rHSFormula="ba644141-cb73-426c-bd5f-8fd1a5ad166a" value="1" displayUnit="min">
+              <Parameter id="1a8469ba-f025-4a27-b055-c20cc843bf83" name="tau" description="time of pulse relaxation" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" value="1" displayUnit="min">
                 <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+                <Origin />
               </Parameter>
-              <MoleculeAmount id="b1f98451-f758-4d2c-96f5-0ea57e0eb108" name="dummy" icon="DRUG" persistable="1" isFixedValue="0" dim="Amount" quantityType="Drug" formula="3e02b8ef-51f3-4c59-b027-c1a51da09e46" mode="Logical" scaleDivisor="1" displayUnit="µmol">
+              <MoleculeAmount id="46d30b48-63a9-4d36-ada3-083eda797dfc" name="dummy" icon="DRUG" persistable="0" isFixedValue="0" dim="Amount" quantityType="Drug" negativeValuesAllowed="1" formula="lVHOwGFwFEaND9SQ75nDpw" mode="Logical" scaleDivisor="1" displayUnit="µmol">
                 <Children>
-                  <Parameter id="2dd3ea11-243f-4625-9e07-0e8376933e3f" name="Start value" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" value="0" displayUnit="µmol/l">
+                  <Parameter id="56062780-a5eb-4ee2-b5d4-b49067c1064e" name="Start value" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" value="0" displayUnit="µmol/l">
                     <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+                    <Origin />
                   </Parameter>
-                  <Parameter id="6897b8e2-fcac-4ebf-8106-a5f362faf4e4" name="Concentration" icon="Parameter" persistable="0" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" formula="b3eac5bb-8491-4c58-9136-af4c8d2cfbef" displayUnit="µmol/l">
+                  <Parameter id="91a8b514-849c-4ca2-98d2-57969d514d22" name="Concentration" icon="Parameter" persistable="1" isFixedValue="0" dim="Concentration (molar)" quantityType="Parameter" negativeValuesAllowed="1" formula="PHD7UbA4Zkm21CD0FqeYOQ" displayUnit="µmol/l">
                     <Info flag="14" seq="1" ref="0" bb="2" group="143" />
+                    <Origin />
                   </Parameter>
                 </Children>
               </MoleculeAmount>
             </Children>
           </Container>
-          <Container id="23e9e5bf-2271-4a98-b7e0-5140e76be6bc" name="Neighborhoods" mode="Logical" containerType="Other" />
-          <Container id="5df765c6-6940-4bb1-8923-bd04493d6f3a" name="dummy" icon="DRUG" mode="Logical" containerType="Molecule" />
+          <Container id="b6416842-9510-4eff-98aa-7826aed5d7d6" name="Neighborhoods" mode="Logical" containerType="Other" />
+          <Container id="835295f6-da11-4a30-a007-c51b9b15abc7" name="dummy" icon="DRUG" mode="Logical" containerType="Molecule" />
         </Children>
       </Root>
       <FormulaCache>
         <Formulas>
-          <Formula id="1afc1864-db67-4097-bbee-c72b4b37fe58" name="Plv" dim="Pressure" formula="(Peslv-Pedlv)*Elv+Pedlv" origin="60339c28-8fdf-46f4-8bd2-2403ac8b5f6f">
+          <Formula id="pr2_qmAGnEiu4vEyJiktxA" name="Plv" dim="Pressure" formula="(Peslv-Pedlv)*Elv+Pedlv" origin="bdde2d7b-9966-4a79-9705-a7a4d941511b">
             <Paths>
               <Path path="0" as="1" />
               <Path path="2" as="3" />
@@ -5385,13 +5541,13 @@
               <Path path="2" as="6" />
             </Paths>
           </Formula>
-          <Formula id="b30c4b7f-b5ca-4126-94ca-16fafc11e5ca" name="Elv1" formula="0.5*(sin(pi*Time/Tes-pi/2)+1)" origin="4b688ad6-f498-45c0-bea8-ec2ba0260249">
+          <Formula id="DqzUGgYMxkCx3bNfM-s_kw" name="Elv1" formula="0.5*(sin(pi*Time/Tes-pi/2)+1)" origin="3e64fb7d-9d44-4d04-8234-1a69eaab0403">
             <Paths>
               <TimePath />
               <Path path="7" as="8" dim="9" />
             </Paths>
           </Formula>
-          <Formula id="4705dd80-695a-468e-8c7d-d9a4898b1933" name="Vlv" dim="Volume per Time" formula="(Pcp-Plv)*aLV/Rvp-(Plv-Pcas)*bLV/Rcs" origin="cac9bc2d-7d22-41c9-b27e-a39597db3df1">
+          <Formula id="6Q6p4KbSykGHlcByVfZr1Q" name="Vlv" dim="Flow" formula="(Pcp-Plv)*aLV/Rvp-(Plv-Pcas)*bLV/Rcs" origin="786f417c-c491-4669-b122-890b61a86468">
             <Paths>
               <Path path="10" as="11" dim="12" />
               <Path path="13" as="14" />
@@ -5402,14 +5558,14 @@
               <Path path="24" as="25" dim="19" />
             </Paths>
           </Formula>
-          <Formula id="ccefa9bf-7862-47e3-aa09-aaa0f86e6b2d" name="Elv2" formula="0.5*exp(-(Time-3*Tes/2)/tau)" origin="99fe214d-25bc-4926-953d-e366d2586977">
+          <Formula id="2phZA2w6RUGu6EH3VvuEsQ" name="Elv2" formula="0.5*exp(-(Time-3*Tes/2)/tau)" origin="04d941e9-88a6-4a08-aec2-35e7726c5fb0">
             <Paths>
               <TimePath />
               <Path path="7" as="8" dim="9" />
               <Path path="26" as="27" dim="9" />
             </Paths>
           </Formula>
-          <Formula id="6780622b-8b26-44fd-8d32-09b7b329f777" name="Elv" formula="Time &lt; 3*Tes/2 ? Elv1 : Elv2" origin="84d7cb46-e552-4f1f-89eb-7b4a62d194d3">
+          <Formula id="-hDOfQ9aWku9fj4pG0zd7w" name="Elv" formula="Time &lt; 3*Tes/2 ? Elv1 : Elv2" origin="7e1e8102-1f6f-4e35-b191-7ee72034ef0b">
             <Paths>
               <TimePath />
               <Path path="28" as="29" />
@@ -5417,39 +5573,38 @@
               <Path path="7" as="8" dim="9" />
             </Paths>
           </Formula>
-          <Formula id="d9e5737e-02a7-4314-8a9e-a9590336c7ab" name="Peslv" dim="Pressure" formula="Eeslv*(Vlv-V0lv)" origin="cf3fe9c6-20b5-4ec5-8281-1bf639586e46">
+          <Formula id="8hs0Nf3WKEqO1Uyt_yrTlA" name="Peslv" dim="Pressure" formula="Eeslv*(Vlv-V0lv)" origin="2ac65c4c-569d-4ece-bb3f-81dce9667499">
             <Paths>
               <Path path="32" as="33" dim="34" />
               <Path path="35" as="36" dim="34" />
               <Path path="37" as="38" dim="19" />
             </Paths>
           </Formula>
-          <Formula id="b37eb208-991d-43e4-9bfe-de22e7437a39" name="Pedlv" dim="Pressure" formula="1*(exp((Vlv-V0lv))-1)" origin="5500540d-3ff1-4954-808f-3c12c337a611">
+          <Formula id="Bgkgi4D4PUO1Lh2kIawFXg" name="Pedlv" dim="Pressure" formula="1*(exp((Vlv-V0lv))-1)" origin="ae6b9801-3375-406f-b12f-5cf1b83313ee">
             <Paths>
               <Path path="32" as="33" dim="34" />
               <Path path="35" as="36" dim="34" />
             </Paths>
           </Formula>
-          <Formula id="3fedf76b-7f13-478f-961e-c6ce8b6d74b2" name="bLV" formula="Plv &gt; Pcas ? 0 : 1" origin="a9e3b09a-d620-4580-8f77-4af308c9aa2a">
+          <Formula id="3CQw8VUhckaAUEw1EW5IzQ" name="bLV" formula="Plv &gt; Pcas ? 0 : 1" origin="ea63d10b-d538-4e03-a5db-298d860310bc">
             <Paths>
               <Path path="10" as="11" dim="39" />
               <Path path="22" as="23" dim="39" />
             </Paths>
           </Formula>
-          <Formula id="f32ad3a0-9967-4517-b90e-63e7edc6aae3" name="aLV" formula="Plv &lt; Pcvp ? 1 : 0" origin="a291b768-878d-4767-9f21-c3bd3ee1a59f">
+          <Formula id="3tx7w0XGcUmOVJ8H6ezlnQ" name="aLV" formula="Plv &lt; Pcvp ? 1 : 0" origin="6e5af217-9da1-4ad8-9c33-028c86fa8c5a">
             <Paths>
               <Path path="10" as="11" dim="12" />
               <Path path="40" as="41" dim="19" />
             </Paths>
           </Formula>
-          <Formula id="b3eac5bb-8491-4c58-9136-af4c8d2cfbef" name="ConcFormula" dim="Concentration (molar)" formula="V&gt;0 ? M/V : 0" origin="bc5858ee-ec07-4592-b490-cd34b6ec17f4">
+          <Formula id="PHD7UbA4Zkm21CD0FqeYOQ" name="ConcFormula" dim="Concentration (molar)" formula="V&gt;0 ? M/V : 0" origin="69e44461-4317-4dba-9ffb-e58690545c46">
             <Paths>
               <Path path="42" as="43" dim="44" />
               <Path path="45" as="46" dim="34" />
             </Paths>
           </Formula>
-          <Formula id="ba644141-cb73-426c-bd5f-8fd1a5ad166a" name="T1" dim="Time per Time" formula="0.1" origin="7705a6bb-3241-412a-81e5-dbc0778e1c96" />
-          <Formula id="3e02b8ef-51f3-4c59-b027-c1a51da09e46" name="Molecule amount" dim="Amount" formula="StartValue * V" origin="Molecule amount">
+          <Formula id="lVHOwGFwFEaND9SQ75nDpw" name="Molecule amount" dim="Amount" formula="StartValue * V" origin="c8ddfc9c-395c-4e6c-a7ab-0158216b1157">
             <Paths>
               <Path path="47" as="48" dim="49" />
               <Path path="50" as="46" dim="34" />
@@ -5469,7 +5624,7 @@
           <Map s="Time" id="9" />
           <Map s="run|Organism|LV|Plv" id="10" />
           <Map s="Plv" id="11" />
-          <Map s="Volume per Time" id="12" />
+          <Map s="Flow" id="12" />
           <Map s="run|Organism|LV|aLV" id="13" />
           <Map s="aLV" id="14" />
           <Map s="run|Organism|LV|bLV" id="15" />
@@ -5511,5 +5666,7 @@
         </StringMap>
       </FormulaCache>
     </Model>
+    <Creation createdAt="5248846165142464863" createdBy="Michael" creationMode="New" origin="Other" />
   </Simulation>
+  <Favorites />
 </SimulationTransfer>
\ No newline at end of file
diff --git a/tests/MoBi.Tests/TestFiles/warnings.pkml b/tests/MoBi.Tests/TestFiles/warnings.pkml
index c205ab9bb..a06527c21 100644
--- a/tests/MoBi.Tests/TestFiles/warnings.pkml
+++ b/tests/MoBi.Tests/TestFiles/warnings.pkml
@@ -1,12 +1,18 @@
 <?xml version="1.0" encoding="utf-8"?>
-<SimulationTransfer version="2">
-  <Simulation id="bc60392d-3522-4856-8e60-8772160f5d8f" name="Warnings">
+<SimulationTransfer id="JkwkHaCoj0O3frwAhKGTgQ" reactionDimensionMode="AmountBased" version="13">
+  <Simulation id="bc60392d-3522-4856-8e60-8772160f5d8f" name="Warnings" icon="Simulation">
     <BuildConfiguration>
-      <Molecules id="bda98b91-9fa0-43a4-95c1-73fb55f14568" name="Molecules">
+      <Molecules id="Co5g1nBHYUmnzZD80PIi5g" name="Molecules" icon="Molecule" bbVersion="0">
+        <Creation createdAt="5248846133422718778" createdBy="Michael" creationMode="New" origin="Other" />
         <Builders>
-          <MoleculeBuilder id="4fe36216-3725-47d1-8572-535e279fa7c5" name="Drug" icon="DRUG" mode="Logical" containerType="Other" isFloating="0" quantityType="Drug" defaultStartFormula="943605cb-6739-4286-8296-3550a3779ddf">
+          <MoleculeBuilder id="SWxlcIvUqEaJ3SuCPZ_o5A" name="Drug" icon="DRUG" mode="Logical" containerType="Other" isFloating="0" quantityType="Drug" isXenobiotic="1" dim="Amount" defaultStartFormula="qFnESqNjB0OM7JB22kSBaQ" displayUnit="µmol">
             <Children>
-              <Parameter id="2085580f-ef54-4108-8be0-933e9f08e413" name="MW" persistable="0" isFixedValue="0" formula="18d665d6-5d1e-4208-a79e-d4bef9fc44e9" dim="MolecularWeight" quantityType="0" buildMode="Property" visible="1" canBeVaried="1" />
+              <Parameter id="isXeZLZOcUawFHfq_UAUJg" name="MW" icon="Parameter" persistable="0" isFixedValue="0" dim="Molecular weight" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="0" value="1.11E-07" displayUnit="g/mol">
+                <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+              </Parameter>
+              <Parameter id="bU_pbOYL30mbn4djSo5BUA" name="Total drug mass" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" formula="AAmImu6lqkuBjjGRHQjtUA" buildMode="Property" isDefault="0" displayUnit="µmol">
+                <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+              </Parameter>
             </Children>
             <UsedCalculationMethods>
               <UsedCalculationMethod category="DistributionCellular" calculationMethod="No Calculation Method" />
@@ -14,14 +20,24 @@
               <UsedCalculationMethod category="DistributionInterstitial" calculationMethod="No Calculation Method" />
             </UsedCalculationMethods>
           </MoleculeBuilder>
-          <MoleculeBuilder id="aba240f4-105b-4336-9198-6f62364cd298" name="Enzyme" icon="ENZYME" mode="Logical" containerType="Other" isFloating="0" quantityType="Enzyme" defaultStartFormula="14d47824-a050-40bf-adf7-270343087104">
+          <MoleculeBuilder id="jfQ-frJS30q1E5g3QiQa8g" name="Enzyme" icon="ENZYME" mode="Logical" containerType="Other" isFloating="0" quantityType="Enzyme" isXenobiotic="1" dim="Amount" defaultStartFormula="ZA3cNQ60Akuv8LOMYJ4fPw" displayUnit="µmol">
+            <Children>
+              <Parameter id="khOf1h2WSkeAvp726RyOPQ" name="Total drug mass" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" formula="AAmImu6lqkuBjjGRHQjtUA" buildMode="Property" isDefault="0" displayUnit="µmol">
+                <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+              </Parameter>
+            </Children>
             <UsedCalculationMethods>
               <UsedCalculationMethod category="DistributionCellular" calculationMethod="No Calculation Method" />
               <UsedCalculationMethod category="DiffusionIntCell" calculationMethod="No Calculation Method" />
               <UsedCalculationMethod category="DistributionInterstitial" calculationMethod="No Calculation Method" />
             </UsedCalculationMethods>
           </MoleculeBuilder>
-          <MoleculeBuilder id="ffc521c8-4cc3-47e4-8626-e49e3ef172bc" name="Complex" mode="Logical" containerType="Other" isFloating="0" quantityType="Complex" defaultStartFormula="9287cd4b-ae73-4b62-8663-388f645f108e">
+          <MoleculeBuilder id="In8pW0jfz0GGz_bBQaF0ig" name="Complex" icon="Complex" mode="Logical" containerType="Other" isFloating="0" quantityType="Complex" isXenobiotic="1" dim="Amount" defaultStartFormula="VfcWevuuwU2hokzFqtUQuw" displayUnit="µmol">
+            <Children>
+              <Parameter id="rDsD3y3os0-BYdw98rWHWg" name="Total drug mass" icon="Parameter" persistable="0" isFixedValue="0" dim="Amount" quantityType="Parameter" negativeValuesAllowed="1" formula="AAmImu6lqkuBjjGRHQjtUA" buildMode="Property" isDefault="0" displayUnit="µmol">
+                <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+              </Parameter>
+            </Children>
             <UsedCalculationMethods>
               <UsedCalculationMethod category="DistributionCellular" calculationMethod="No Calculation Method" />
               <UsedCalculationMethod category="DiffusionIntCell" calculationMethod="No Calculation Method" />
@@ -31,68 +47,81 @@
         </Builders>
         <FormulaCache>
           <Formulas>
-            <ConstantFormula id="18d665d6-5d1e-4208-a79e-d4bef9fc44e9" dim="MolecularWeight" value="111" />
-            <ConstantFormula id="943605cb-6739-4286-8296-3550a3779ddf" dim="Amount" value="0" />
-            <ConstantFormula id="14d47824-a050-40bf-adf7-270343087104" dim="Amount" value="0" />
-            <ConstantFormula id="9287cd4b-ae73-4b62-8663-388f645f108e" dim="Amount" value="0" />
+            <SumFormula id="AAmImu6lqkuBjjGRHQjtUA" name="PARAM_TotalDrugMass" dim="Amount" variable="P" formulaString="P_#i">
+              <Criteria>
+                <DescriptorConditions>
+                  <MatchTagCondition tag="MOLECULE" />
+                  <MatchTagCondition tag="DrugMass" />
+                </DescriptorConditions>
+              </Criteria>
+            </SumFormula>
+            <ConstantFormula id="qFnESqNjB0OM7JB22kSBaQ" dim="Amount" value="0" />
+            <ConstantFormula id="ZA3cNQ60Akuv8LOMYJ4fPw" dim="Amount" value="0" />
+            <ConstantFormula id="VfcWevuuwU2hokzFqtUQuw" dim="Amount" value="0" />
           </Formulas>
           <StringMap />
         </FormulaCache>
       </Molecules>
-      <Observers id="d8ace384-3cfc-40db-bbe6-c4f264193a26" name="Observer">
+      <Observers id="J_8RnWxgsk2PdDupzV_YyQ" name="Observer" icon="Observer" bbVersion="0">
+        <Creation createdAt="5248846133424015325" createdBy="Michael" creationMode="New" origin="Other" />
         <Builders>
-          <AmountObserverBuilder id="ff991d18-0eea-45b2-887c-e4105b5e073a" name="Concentration" forAll="1" dimension="MolarConcentration" formula="d77dbdd5-be28-4f46-aa46-c60b6178a729">
+          <AmountObserverBuilder id="dHH71Sk0d06GJYJhDs1jOA" name="Concentration" icon="Observer" dimension="Concentration (molar)" formula="7AwwE1eQV0aYMbgamrqSyg">
             <ContainerCriteria>
               <DescriptorConditions>
                 <MatchAllCondition />
               </DescriptorConditions>
             </ContainerCriteria>
+            <MoleculeList forAll="1" />
           </AmountObserverBuilder>
-          <AmountObserverBuilder id="24a3cc2b-f631-4421-9e3a-a47461148fc1" name="Mass" forAll="1" dimension="Mass" formula="27a87f7b-3df7-4d84-87cb-52badfd74df4">
+          <AmountObserverBuilder id="P22avPK3okivMKFWaelicQ" name="Mass" icon="Observer" dimension="Mass" formula="3cTe_qugxkCK5j5io8gCPA">
             <ContainerCriteria>
               <DescriptorConditions>
                 <MatchAllCondition />
               </DescriptorConditions>
             </ContainerCriteria>
+            <MoleculeList forAll="1" />
           </AmountObserverBuilder>
-          <AmountObserverBuilder id="9f2b2703-dc2b-4f61-8f95-cc81e535cf5d" name="Never" forAll="1" dimension="Dimensionless" formula="7c2a641b-4a9e-42a3-9961-6eb134252a15">
+          <AmountObserverBuilder id="VqCl31QjpEaOUD4JlNc07g" name="Never" icon="Observer" formula="z1sKC1MtdUS096HKE7RvAg">
             <ContainerCriteria>
               <DescriptorConditions>
                 <MatchAllCondition />
               </DescriptorConditions>
             </ContainerCriteria>
-            <MoleculeNames>
-              <MoleculeName>Drug</MoleculeName>
-            </MoleculeNames>
+            <MoleculeList forAll="1">
+              <MoleculeNames>
+                <MoleculeNamesChild>Drug</MoleculeNamesChild>
+              </MoleculeNames>
+            </MoleculeList>
           </AmountObserverBuilder>
-          <ContainerObserverBuilder id="0ef6ff9b-48b4-41eb-bf2b-9f6e6ebfbda0" name="NeverAgain" forAll="1" dimension="Dimensionless" formula="007e53d2-c9da-4754-8f74-c4183c1e2f06">
+          <ContainerObserverBuilder id="zQMsuJWjPUqbqrSNDqFSfA" name="NeverAgain" icon="Observer" formula="skLjoqaVOk-UOCa9CB3P4Q">
             <ContainerCriteria>
               <DescriptorConditions>
                 <MatchTagCondition tag="C" />
               </DescriptorConditions>
             </ContainerCriteria>
+            <MoleculeList forAll="1" />
           </ContainerObserverBuilder>
         </Builders>
         <FormulaCache>
           <Formulas>
-            <Formula id="d77dbdd5-be28-4f46-aa46-c60b6178a729" name="Conc" dim="MolarConcentration" formula="M/V">
+            <Formula id="7AwwE1eQV0aYMbgamrqSyg" name="Conc" dim="Concentration (molar)" formula="M/V">
               <Paths>
                 <Path path="0" as="1" dim="2" />
                 <Path path="3" as="4" dim="5" />
               </Paths>
             </Formula>
-            <Formula id="27a87f7b-3df7-4d84-87cb-52badfd74df4" name="mass" dim="Mass" formula="M*MW">
+            <Formula id="3cTe_qugxkCK5j5io8gCPA" name="mass" dim="Mass" formula="M*MW">
               <Paths>
                 <Path path="0" as="1" dim="2" />
                 <Path path="6" as="7" dim="8" />
               </Paths>
             </Formula>
-            <Formula id="7c2a641b-4a9e-42a3-9961-6eb134252a15" name="P1" dim="Dimensionless" formula="P1">
+            <Formula id="z1sKC1MtdUS096HKE7RvAg" name="P1" formula="P1">
               <Paths>
                 <Path path="9" as="10" dim="2" />
               </Paths>
             </Formula>
-            <Formula id="007e53d2-c9da-4754-8f74-c4183c1e2f06" name="null" dim="Dimensionless" formula="0" />
+            <Formula id="skLjoqaVOk-UOCa9CB3P4Q" name="null" formula="0" />
           </Formulas>
           <StringMap>
             <Map s=".." id="0" />
@@ -103,25 +132,23 @@
             <Map s="Volume" id="5" />
             <Map s="MOLECULE|MW" id="6" />
             <Map s="MW" id="7" />
-            <Map s="MolecularWeight" id="8" />
+            <Map s="Molecular weight" id="8" />
             <Map s="..|..|P1" id="9" />
             <Map s="P1" id="10" />
           </StringMap>
         </FormulaCache>
       </Observers>
-      <EventGroups id="25a6ed32-e15d-47f7-9664-a1cd1e366284" name="Events">
-        <FormulaCache>
-          <StringMap />
-        </FormulaCache>
+      <EventGroups id="m--B3Xko1EeO5JUuS9sOpQ" name="Events" icon="EventGroup" bbVersion="0">
+        <Creation createdAt="5248846133424045240" createdBy="Michael" creationMode="New" origin="Other" />
       </EventGroups>
-      <PassiveTransports id="e7b43ce0-f5c2-4bf3-83ea-893078dd2d59" name="Passive Transports">
-        <FormulaCache>
-          <StringMap />
-        </FormulaCache>
+      <PassiveTransports id="Z4u1FbnJ6EKf66E7AvuFbw" name="Passive Transports" icon="PassiveTransport" bbVersion="0">
+        <Creation createdAt="5248846133424005351" createdBy="Michael" creationMode="New" origin="Other" />
       </PassiveTransports>
-      <Reactions id="68ac02e7-58e5-4cf5-85a6-a57679f6eacc" name="Reaction">
+      <Reactions id="ny29pq_oxkeT7jmbEwUoeg" name="Reaction" icon="Reaction" bbVersion="0">
+        <Creation createdAt="5248846133423207474" createdBy="Michael" creationMode="New" origin="Other" />
         <Builders>
-          <ReactionBuilder id="fab48d0f-2841-40b7-bd1d-c1d4d6519cd5" name="R1" dimension="Rate" createProcessRateParameter="0" formula="b15db3b2-ca34-438a-97d6-0eb1aecbd38a">
+          <ReactionBuilder id="tZoIDxIpE0WjTtg0RqxqIA" name="R1" icon="Reaction" mode="Logical" containerType="Reaction" dimension="Amount per time" createProcessRateParameter="0" processRateParameterPersistable="0" formula="iwcziEnAdESZ8PbnvEitpQ">
+            <ContainerCriteria />
             <Educts>
               <ReactionPartnerBuilder moleculeName="Drug" stoichiometricCoefficient="1" />
               <ReactionPartnerBuilder moleculeName="Enzyme" stoichiometricCoefficient="1" />
@@ -133,7 +160,7 @@
         </Builders>
         <FormulaCache>
           <Formulas>
-            <Formula id="b15db3b2-ca34-438a-97d6-0eb1aecbd38a" name="F1" dim="Rate" formula="(Drug+Enzyme)/2">
+            <Formula id="iwcziEnAdESZ8PbnvEitpQ" name="F1" dim="Amount per time" formula="(Drug+Enzyme)/2">
               <Paths>
                 <Path path="0" as="1" dim="2" />
                 <Path path="3" as="4" dim="2" />
@@ -151,118 +178,97 @@
             <Map s="Enzyme" id="6" />
           </StringMap>
         </FormulaCache>
-        <DiagramModel IsLayouted="True">
-          <ReactionNode Id="fab48d0f-2841-40b7-bd1d-c1d4d6519cd5" Name="R1" Location="66.23125 30.5999985" Size="38 36.0729141" Hidden="false" IsVisible="true" LocationFixed="false" UserFlags="6" Description="R1" NodeSize="Middle" DisplayEductsRight="false" />
-          <MoleculeNode Id="43258d44-124b-4369-8a60-450d707db84d" Name="Drug" Location="-43.8000069 5.59999847" Size="38.11979 15" Hidden="false" IsVisible="true" LocationFixed="false" UserFlags="4" Description="Drug" NodeSize="Middle" />
-          <MoleculeNode Id="a34d1c8a-29bb-436b-878f-586f3d2e4e7d" Name="Enzyme" Location="-43.8000031 80.6" Size="53.5312462 15" Hidden="false" IsVisible="true" LocationFixed="false" UserFlags="4" Description="Enzyme" NodeSize="Middle" />
-          <MoleculeNode Id="4a7686b6-2de4-4642-8ebe-7682c94c72e5" Name="Complex" Location="137.731247 30.5999985" Size="57.1510468 15" Hidden="false" IsVisible="true" LocationFixed="false" UserFlags="4" Description="Complex" NodeSize="Middle" />
-        </DiagramModel>
       </Reactions>
-      <SpatialStructure id="ee3f7164-b83c-409a-8c1d-433de6eef53c" name="Organism">
-        <GlobalMoleculeDependentProperties id="2883c4de-bdd5-443e-9161-0b48401a9ac3" name="MoleculeProperties" mode="Logical" containerType="Molecule" />
+      <SpatialStructure id="Xmpmg4vsEEGz5CR2TcMJVQ" name="Organism" icon="SpatialStructure" bbVersion="0">
+        <Creation createdAt="5248846133422738727" createdBy="Michael" creationMode="New" origin="Other" />
+        <GlobalMoleculeDependentProperties id="QyZHm52cEUSvafvraSM_cg" name="MoleculeProperties" mode="Logical" containerType="Molecule" />
         <TopContainers>
-          <Container id="8624a02c-7bd8-40b0-8494-0013575603af" name="Organism" mode="Logical" containerType="Organism">
+          <Container id="3kP0IzDRlEK-78QVvQ5XhQ" name="Organism" mode="Logical" containerType="Organism">
             <Tags>
               <Tag value="Organism" />
             </Tags>
             <Children>
-              <Container id="bbbc22d8-9c98-4eac-81d6-2c7df3c09767" name="MoleculeProperties" mode="Logical" containerType="Other" />
-              <Container id="f8e2c742-a9cb-4f09-93e2-597864eedbf3" name="Comp1" mode="Physical" containerType="Compartment">
+              <Container id="Ak-PBXixbkCj2mDtmzVXJg" name="MoleculeProperties" mode="Logical" containerType="Other" />
+              <Container id="EfoWdhGU10CO6_8Zh4QeQg" name="Comp1" mode="Physical" containerType="Compartment">
                 <Tags>
                   <Tag value="Comp1" />
                 </Tags>
                 <Children>
-                  <Container id="13f7877f-77c9-4190-b5bc-91820be0bb71" name="MoleculeProperties" mode="Logical" containerType="Other" />
-                  <Parameter id="0a74891a-82eb-41c4-a6ad-73bdcc2f681b" name="V" persistable="0" isFixedValue="0" formula="c8ffade9-7122-448b-a4a4-f7773bb27370" dim="Volume" quantityType="0" visible="1" canBeVaried="1" />
+                  <Container id="u6LZN0vEv0OYvYrzcvoHdw" name="MoleculeProperties" mode="Logical" containerType="Other" />
+                  <Parameter id="WYqayMeqqki1KwV5xUceJA" name="V" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="0" value="1" displayUnit="l">
+                    <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+                  </Parameter>
                 </Children>
               </Container>
-              <Container id="fd2abc2d-d4ca-4945-b83b-bc6a321b20c9" name="Comp2" mode="Physical" containerType="Compartment">
+              <Container id="ddch3FuMAUmTm0g3XxqdUg" name="Comp2" mode="Physical" containerType="Compartment">
                 <Tags>
                   <Tag value="Comp2" />
                 </Tags>
                 <Children>
-                  <Container id="d38465bb-a158-4972-9dd7-7be9279758d3" name="MoleculeProperties" mode="Logical" containerType="Other" />
+                  <Container id="80GbYCCVvEWBTxCv08Mhnw" name="MoleculeProperties" mode="Logical" containerType="Other" />
                 </Children>
               </Container>
-              <Container id="21063a6e-0275-4a1f-82ab-a1f0727a8632" name="Comp3" mode="Physical" containerType="Compartment">
+              <Container id="nFTqVjzo20msamA6A6bOBA" name="Comp3" mode="Physical" containerType="Compartment">
                 <Tags>
                   <Tag value="Comp3" />
                 </Tags>
                 <Children>
-                  <Container id="daf74b03-f360-4d65-8a92-77cad475b6c5" name="MoleculeProperties" mode="Logical" containerType="Other" />
-                  <Parameter id="f8fe7bc1-d225-4049-8140-d1c074d37fb5" name="V" persistable="0" isFixedValue="0" formula="3570898f-01ed-431a-b10b-6c9444129152" dim="Volume" quantityType="0" visible="1" canBeVaried="1" />
+                  <Container id="1t-44Cc5YEmbGSefpBQtiA" name="MoleculeProperties" mode="Logical" containerType="Other" />
+                  <Parameter id="bG3mfDa8XE2w5DnwKPzYwQ" name="V" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="0" value="1" displayUnit="l">
+                    <Info flag="10" seq="1" ref="0" bb="2" group="143" />
+                  </Parameter>
                 </Children>
               </Container>
             </Children>
           </Container>
         </TopContainers>
-        <NeighborhoodsContainer id="c0e984f7-b25f-4843-8f26-90642339a102" name="Neighborhoods" mode="Logical" containerType="Other" />
-        <FormulaCache>
-          <Formulas>
-            <ConstantFormula id="c8ffade9-7122-448b-a4a4-f7773bb27370" dim="Volume" value="1" />
-            <ConstantFormula id="3570898f-01ed-431a-b10b-6c9444129152" dim="Volume" value="1" />
-          </Formulas>
-          <StringMap />
-        </FormulaCache>
-        <DiagramModel IsLayouted="True">
-          <SimpleContainerNode Id="c0e984f7-b25f-4843-8f26-90642339a102" Name="Neighborhoods" Location="-147.998032 -36.7005157" Size="111.899719 21.0911446" Hidden="false" IsVisible="false" LocationFixed="false" UserFlags="1" Description="Neighborhoods" IsLogical="true" IsExpanded="true" IsExpandedByDefault="false" />
-          <SimpleContainerNode Id="8624a02c-7bd8-40b0-8494-0013575603af" Name="Organism" Location="-85.04817 -27.7005157" Size="300.283875 103.4557" Hidden="false" IsVisible="true" LocationFixed="true" UserFlags="1" Description="Organism" IsLogical="true" IsExpanded="true" IsExpandedByDefault="true">
-            <SimpleContainerNode Id="bbbc22d8-9c98-4eac-81d6-2c7df3c09767" Name="MoleculeProperties" Location="-5.048172 39.755188" Size="137.049469 21.0911446" Hidden="false" IsVisible="false" LocationFixed="false" UserFlags="1" Description="MoleculeProperties" IsLogical="true" IsExpanded="true" IsExpandedByDefault="false" />
-            <SimpleContainerNode Id="f8e2c742-a9cb-4f09-93e2-597864eedbf3" Name="Comp1" Location="-70.04817 21.6640472" Size="62.28385 21.0911446" Hidden="false" IsVisible="true" LocationFixed="false" UserFlags="1" Description="Comp1" IsLogical="false" IsExpanded="true" IsExpandedByDefault="false">
-              <SimpleContainerNode Id="13f7877f-77c9-4190-b5bc-91820be0bb71" Name="MoleculeProperties" Location="-147.8138 54.8463326" Size="137.049469 21.0911446" Hidden="false" IsVisible="false" LocationFixed="false" UserFlags="1" Description="MoleculeProperties" IsLogical="true" IsExpanded="true" IsExpandedByDefault="false" />
-            </SimpleContainerNode>
-            <SimpleContainerNode Id="fd2abc2d-d4ca-4945-b83b-bc6a321b20c9" Name="Comp2" Location="149.951828 51.66405" Size="62.28385 21.0911446" Hidden="false" IsVisible="true" LocationFixed="false" UserFlags="1" Description="Comp2" IsLogical="false" IsExpanded="true" IsExpandedByDefault="false">
-              <SimpleContainerNode Id="d38465bb-a158-4972-9dd7-7be9279758d3" Name="MoleculeProperties" Location="72.18622 84.84633" Size="137.049469 21.0911446" Hidden="false" IsVisible="false" LocationFixed="false" UserFlags="1" Description="MoleculeProperties" IsLogical="true" IsExpanded="true" IsExpandedByDefault="false" />
-            </SimpleContainerNode>
-            <SimpleContainerNode Id="21063a6e-0275-4a1f-82ab-a1f0727a8632" Name="Comp3" Location="66.80989 -9.609371" Size="62.28385 21.0911446" Hidden="false" IsVisible="true" LocationFixed="false" UserFlags="1" Description="Comp3" IsLogical="false" IsExpanded="true" IsExpandedByDefault="false">
-              <SimpleContainerNode Id="daf74b03-f360-4d65-8a92-77cad475b6c5" Name="MoleculeProperties" Location="-10.9557037 23.5729046" Size="137.049469 21.0911446" Hidden="false" IsVisible="false" LocationFixed="false" UserFlags="1" Description="MoleculeProperties" IsLogical="true" IsExpanded="true" IsExpandedByDefault="false" />
-            </SimpleContainerNode>
-          </SimpleContainerNode>
-        </DiagramModel>
+        <NeighborhoodsContainer id="uo93xmpeJk-sVkNHw9ziNg" name="Neighborhoods" mode="Logical" containerType="Other" />
       </SpatialStructure>
-      <ParameterStartValues id="52608c6b-e01d-4889-8bf7-d9e1987108cc" name="psv" spatialStructureId="b946a700-b32d-45ed-9be6-890cfbc21547" moleculeBuildingBlockId="f0be3394-fcc7-45ef-8b37-902b7eb683ab">
+      <ParameterStartValues id="8itH-AvZCkGK4gukjHlfHw" name="psv" icon="ParameterStartValues" bbVersion="0" spatialStructureId="ee3f7164-b83c-409a-8c1d-433de6eef53c" moleculeBuildingBlockId="bda98b91-9fa0-43a4-95c1-73fb55f14568">
+        <Creation createdAt="5248846133424055223" createdBy="Michael" creationMode="New" origin="Other" />
         <Builders>
-          <ParameterStartValue startValue="1" dimension="Volume">
-            <ParameterPath path="0" />
+          <ParameterStartValue id="qDatl6uXQE2w5pMPe35Z9g" name="V" dimension="Volume" startValue="1" isDefault="0" displayUnit="l">
+            <ContainerPath path="0" />
           </ParameterStartValue>
-          <ParameterStartValue startValue="1" dimension="Volume">
-            <ParameterPath path="1" />
+          <ParameterStartValue id="MVisUvwAO06BkSyTR2HNIg" name="V" dimension="Volume" startValue="1" isDefault="0" displayUnit="l">
+            <ContainerPath path="1" />
           </ParameterStartValue>
         </Builders>
         <FormulaCache>
           <StringMap>
-            <Map s="Organism|Comp1|V" id="0" />
-            <Map s="Organism|Comp3|V" id="1" />
+            <Map s="Organism|Comp1" id="0" />
+            <Map s="Organism|Comp3" id="1" />
           </StringMap>
         </FormulaCache>
       </ParameterStartValues>
-      <MoleculeStartValues id="f9a07d82-7d22-4912-af0f-db8d5388ba55" name="msv">
+      <MoleculeStartValues id="3BqSUPwewUe249AbLK0rqA" name="msv" icon="MoleculeStartValues" bbVersion="0" spatialStructureId="ee3f7164-b83c-409a-8c1d-433de6eef53c" moleculeBuildingBlockId="bda98b91-9fa0-43a4-95c1-73fb55f14568">
+        <Creation createdAt="5248846133424090500" createdBy="Michael" creationMode="New" origin="Other" />
         <Builders>
-          <MoleculeStartValue isPresent="0" moleculeName="Drug" startValue="0">
+          <MoleculeStartValue id="HUPIaymNLUeKAkEUyYvSJA" name="Drug" dimension="Amount" startValue="0" scaleDivisor="1" isPresent="0" negativeValuesAllowed="0" displayUnit="µmol">
             <ContainerPath path="0" />
           </MoleculeStartValue>
-          <MoleculeStartValue isPresent="1" moleculeName="Enzyme" startValue="0">
+          <MoleculeStartValue id="0gzehi_qP023m2dip1pA4A" name="Enzyme" dimension="Amount" startValue="0" scaleDivisor="1" isPresent="1" negativeValuesAllowed="0" displayUnit="µmol">
             <ContainerPath path="0" />
           </MoleculeStartValue>
-          <MoleculeStartValue isPresent="1" moleculeName="Complex" startValue="0">
+          <MoleculeStartValue id="AoAjqKb8XEiuuQytWaIiwQ" name="Complex" dimension="Amount" startValue="0" scaleDivisor="1" isPresent="1" negativeValuesAllowed="0" displayUnit="µmol">
             <ContainerPath path="0" />
           </MoleculeStartValue>
-          <MoleculeStartValue isPresent="1" moleculeName="Drug" startValue="0">
+          <MoleculeStartValue id="XzN6wLsLXE2loYVN5EolLQ" name="Drug" dimension="Amount" startValue="0" scaleDivisor="1" isPresent="1" negativeValuesAllowed="0" displayUnit="µmol">
             <ContainerPath path="1" />
           </MoleculeStartValue>
-          <MoleculeStartValue isPresent="0" moleculeName="Enzyme" startValue="0">
+          <MoleculeStartValue id="KAR4RtALekuuGG9zlC0kNw" name="Enzyme" dimension="Amount" startValue="0" scaleDivisor="1" isPresent="0" negativeValuesAllowed="0" displayUnit="µmol">
             <ContainerPath path="1" />
           </MoleculeStartValue>
-          <MoleculeStartValue isPresent="1" moleculeName="Complex" startValue="0">
+          <MoleculeStartValue id="7m1cDysEek2s0dQevaeW7w" name="Complex" dimension="Amount" startValue="0" scaleDivisor="1" isPresent="1" negativeValuesAllowed="0" displayUnit="µmol">
             <ContainerPath path="1" />
           </MoleculeStartValue>
-          <MoleculeStartValue isPresent="1" moleculeName="Drug" startValue="0">
+          <MoleculeStartValue id="F5Q_Zqfb3kivv6lu7U4_oA" name="Drug" dimension="Amount" startValue="0" scaleDivisor="1" isPresent="1" negativeValuesAllowed="0" displayUnit="µmol">
             <ContainerPath path="2" />
           </MoleculeStartValue>
-          <MoleculeStartValue isPresent="1" moleculeName="Enzyme" startValue="0">
+          <MoleculeStartValue id="RZu1lBFFmEyj019x_PRs6A" name="Enzyme" dimension="Amount" startValue="0" scaleDivisor="1" isPresent="1" negativeValuesAllowed="0" displayUnit="µmol">
             <ContainerPath path="2" />
           </MoleculeStartValue>
-          <MoleculeStartValue isPresent="0" moleculeName="Complex" startValue="0">
+          <MoleculeStartValue id="kroCO75yp0iMlTGINVbv5Q" name="Complex" dimension="Amount" startValue="0" scaleDivisor="1" isPresent="0" negativeValuesAllowed="0" displayUnit="µmol">
             <ContainerPath path="2" />
           </MoleculeStartValue>
         </Builders>
@@ -274,11 +280,58 @@
           </StringMap>
         </FormulaCache>
       </MoleculeStartValues>
+      <SimulationSettings id="qmAS77zLVkWLxkdP9PKZ3w" name="Warnings" icon="SimulationSettings" bbVersion="0" randomSeed="22594468">
+        <Creation createdAt="5248846133424025296" createdBy="Michael" creationMode="New" origin="Other" />
+        <Solver id="BdXqJ3SyfESsoQOOcdLuVw" name="CVODE1002_2" mode="Logical" containerType="Other">
+          <Children>
+            <Parameter id="CYLpZ4C-SEqRY75-aZ18YA" name="Absolute tolerance" icon="PARAMETER" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="0" value="1E-09">
+              <Info flag="10" seq="1" ref="0" bb="2" group="100" />
+            </Parameter>
+            <Parameter id="_ZG9QQwphUugxH6tKEWB0w" name="Relative tolerance" icon="PARAMETER" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="0" value="0.0001">
+              <Info flag="10" seq="1" ref="0" bb="2" group="100" />
+            </Parameter>
+            <Parameter id="FJ3eXEf2LkeYsx8ws-xj9g" name="H0" icon="PARAMETER" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="0" value="1E-10">
+              <Info flag="10" seq="1" ref="0" bb="2" group="100" />
+            </Parameter>
+            <Parameter id="206DfR1vNUuw0qrez_VhwA" name="HMax" icon="PARAMETER" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="0" value="60">
+              <Info flag="10" seq="1" ref="0" bb="2" group="100" />
+            </Parameter>
+            <Parameter id="Nrnbax6i2U-I7vyGHPHnrw" name="HMin" icon="PARAMETER" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="0" value="0">
+              <Info flag="10" seq="1" ref="0" bb="2" group="100" />
+            </Parameter>
+            <Parameter id="TWvU9LJcLUuamb8GNJudog" name="MxStep" icon="PARAMETER" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="0" value="100000">
+              <Info flag="10" seq="1" ref="0" bb="2" group="100" />
+            </Parameter>
+            <Parameter id="jLe_eth6HUqw7Ro1UDvMWA" name="Use Jacobian" icon="PARAMETER" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="0" value="1">
+              <Info flag="10" seq="1" ref="0" bb="2" group="100" />
+            </Parameter>
+          </Children>
+        </Solver>
+        <OutputSchema id="iAC50SifXUe1uNzvYgLSmg" name="Output schema" mode="Logical" containerType="Other">
+          <Children>
+            <OutputInterval id="ZTSa30qJ8kqUDXxfVFAg3w" name="Output interval 0" mode="Logical" containerType="Other">
+              <Children>
+                <Parameter id="RHG4J8tEGEugnl5hX2chvg" name="Start time" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="0" value="0" displayUnit="h">
+                  <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+                </Parameter>
+                <Parameter id="BPJCm3D5gESqghYRW_x8qg" name="End time" icon="Parameter" persistable="0" isFixedValue="0" dim="Time" quantityType="Parameter" negativeValuesAllowed="1" isDefault="0" value="1440" displayUnit="h">
+                  <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+                </Parameter>
+                <Parameter id="vWkpmafgsE6pD42Ap66T1A" name="Resolution" icon="Parameter" persistable="0" isFixedValue="0" dim="Resolution" quantityType="Parameter" negativeValuesAllowed="1" isDefault="0" value="0.0666666666666667" displayUnit="pts/h">
+                  <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+                </Parameter>
+              </Children>
+            </OutputInterval>
+          </Children>
+        </OutputSchema>
+        <OutputSelections />
+      </SimulationSettings>
       <AllCalculationMethods>
-        <CoreCalculationMethod id="9e48e72c-a968-4720-807f-0cf81d057eaa" name="Cellular partition coefficient method - Berezhkovskiy" category="DistributionCellular">
+        <CoreCalculationMethod id="9e48e72c-a968-4720-807f-0cf81d057eaa" name="Cellular partition coefficient method - Berezhkovskiy" icon="CoreCalculationMethod" bbVersion="0" category="DistributionCellular">
+          <Creation createdAt="5248846133421142854" createdBy="Michael" creationMode="New" origin="Other" />
           <OutputFormulas>
             <KeyValue>
-              <Formula id="d4601dd2-6121-44f6-bd82-cda6994bab47" name="PARAM_K_rbc" dim="Dimensionless" formula="(f_water_rbc + f_lipids_rbc * 10^LogMA + f_proteins_rbc * KProt)*fu">
+              <Formula id="d4601dd2-6121-44f6-bd82-cda6994bab47" name="PARAM_K_rbc" formula="(f_water_rbc + f_lipids_rbc * 10^LogMA + f_proteins_rbc * KProt)*fu">
                 <Paths>
                   <Path path="0" as="1" dim="2" />
                   <Path path="3" as="4" dim="5" />
@@ -297,7 +350,7 @@
               </ParameterDescriptor>
             </KeyValue>
             <KeyValue>
-              <Formula id="fa6b9c40-3943-47b1-b226-9e9d668953b3" name="PARAM_K_cell_pls_Berezhkovskiy" dim="Dimensionless" formula="(10^LogP * (V_nlt + 0.3 * V_pht) +  0.7 * V_pht + V_wt / fu_t) / (10^LogP * (V_nlp + 0.3 * V_php) +  0.7 * V_php + V_wp / fu)">
+              <Formula id="fa6b9c40-3943-47b1-b226-9e9d668953b3" name="PARAM_K_cell_pls_Berezhkovskiy" formula="(10^LogP * (V_nlt + 0.3 * V_pht) +  0.7 * V_pht + V_wt / fu_t) / (10^LogP * (V_nlp + 0.3 * V_php) +  0.7 * V_php + V_wp / fu)">
                 <Paths>
                   <Path path="14" as="15" dim="2" />
                   <Path path="0" as="1" dim="2" />
@@ -320,7 +373,7 @@
               </ParameterDescriptor>
             </KeyValue>
             <KeyValue>
-              <Formula id="c1fb0773-e449-4d14-9ea6-097cba5dc8e0" name="PARAM_K_cell_pls_fat" dim="Dimensionless" formula="(10^LogP_ow * (V_nlt + 0.3 * V_pht) +  0.7 * V_pht + V_wt / fu_t) / (10^LogP_ow * (V_nlp + 0.3 * V_php) +  0.7 * V_php + V_wp / fu)">
+              <Formula id="c1fb0773-e449-4d14-9ea6-097cba5dc8e0" name="PARAM_K_cell_pls_fat" formula="(10^LogP_ow * (V_nlt + 0.3 * V_pht) +  0.7 * V_pht + V_wt / fu_t) / (10^LogP_ow * (V_nlp + 0.3 * V_php) +  0.7 * V_php + V_wp / fu)">
                 <Paths>
                   <Path path="14" as="15" dim="2" />
                   <Path path="0" as="1" dim="2" />
@@ -345,7 +398,9 @@
           </OutputFormulas>
           <HelpParameters>
             <KeyValue>
-              <Parameter id="ae26f32d-c529-4221-b1d4-10496de2ea0c" name="logP (oil/water,pKa)" persistable="0" isFixedValue="0" formula="c7dfd783-7f09-4cc0-b912-5a8192058b10" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="ae26f32d-c529-4221-b1d4-10496de2ea0c" name="logP (oil/water,pKa)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="c7dfd783-7f09-4cc0-b912-5a8192058b10" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -353,7 +408,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="f5cd878d-3e2c-4f56-ab00-3036746d4113" name="logP (veg.oil/water)" persistable="0" isFixedValue="0" formula="693e6dfa-5603-4b70-9ccc-185670132546" dim="Lipophilicity" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="f5cd878d-3e2c-4f56-ab00-3036746d4113" name="logP (veg.oil/water)" icon="Parameter" persistable="0" isFixedValue="0" dim="Log Units" quantityType="Parameter" negativeValuesAllowed="1" formula="693e6dfa-5603-4b70-9ccc-185670132546" isDefault="0" displayUnit="Log Units">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -361,7 +418,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="8ac31d9b-74c4-4ac6-af09-c45dbdc1305a" name="LogPow_pKa_DiproticAcid" persistable="0" isFixedValue="0" formula="9641e3e4-ced3-40f8-866c-31c57fa330ea" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="8ac31d9b-74c4-4ac6-af09-c45dbdc1305a" name="LogPow_pKa_DiproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="9641e3e4-ced3-40f8-866c-31c57fa330ea" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -369,7 +428,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="5d1c4917-3369-4774-a801-214371fafe3b" name="LogPow_pKa_DiproticBase" persistable="0" isFixedValue="0" formula="00f63719-e5f2-4f6f-ad3d-f99bce65d360" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="5d1c4917-3369-4774-a801-214371fafe3b" name="LogPow_pKa_DiproticBase" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="00f63719-e5f2-4f6f-ad3d-f99bce65d360" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -377,7 +438,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="10274005-aad3-4c26-a83c-3acf5f46a791" name="LogPow_pKa_DiproticBaseMonoproticAcid" persistable="0" isFixedValue="0" formula="6fb245f2-8403-4b03-8045-4caa27d8bb36" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="10274005-aad3-4c26-a83c-3acf5f46a791" name="LogPow_pKa_DiproticBaseMonoproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="6fb245f2-8403-4b03-8045-4caa27d8bb36" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -385,7 +448,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="43b7f47b-34c1-40b8-862d-139fd2a724c6" name="LogPow_pKa_MonoproticAcid" persistable="0" isFixedValue="0" formula="bdb0eb0c-242a-4064-b643-63ef739548a1" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="43b7f47b-34c1-40b8-862d-139fd2a724c6" name="LogPow_pKa_MonoproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="bdb0eb0c-242a-4064-b643-63ef739548a1" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -393,7 +458,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="13ee7b73-2c31-496b-ba25-b122ab27351d" name="LogPow_pKa_MonoproticBase" persistable="0" isFixedValue="0" formula="51dbb44a-af66-403b-a335-114b606f2051" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="13ee7b73-2c31-496b-ba25-b122ab27351d" name="LogPow_pKa_MonoproticBase" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="51dbb44a-af66-403b-a335-114b606f2051" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -401,7 +468,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="25fa93f1-fd6d-4164-ba25-3ad7d9d77c8f" name="LogPow_pKa_MonoproticBaseDiproticAcid" persistable="0" isFixedValue="0" formula="46587d58-bf23-4cba-8295-bbb529bdad10" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="25fa93f1-fd6d-4164-ba25-3ad7d9d77c8f" name="LogPow_pKa_MonoproticBaseDiproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="46587d58-bf23-4cba-8295-bbb529bdad10" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -409,7 +478,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="d3852df5-5b3a-4d41-933c-487dea859ce9" name="LogPow_pKa_MonoproticBaseMonoproticAcid" persistable="0" isFixedValue="0" formula="a0dd64cf-25ee-4847-8509-5cc650d56702" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="d3852df5-5b3a-4d41-933c-487dea859ce9" name="LogPow_pKa_MonoproticBaseMonoproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="a0dd64cf-25ee-4847-8509-5cc650d56702" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -417,7 +488,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="b1c15e7b-f23f-4d2b-bdda-51e7b8b54bb1" name="LogPow_pKa_Neutral" persistable="0" isFixedValue="0" formula="f17df6cc-5bd8-43e9-8439-71a0f458b91a" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="b1c15e7b-f23f-4d2b-bdda-51e7b8b54bb1" name="LogPow_pKa_Neutral" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="0" value="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -425,7 +498,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="11832511-459f-4bda-ad82-cf5b750163f6" name="LogPow_pKa_TriproticAcid" persistable="0" isFixedValue="0" formula="4c531a91-b6a1-459c-8aea-770e63b51db0" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="11832511-459f-4bda-ad82-cf5b750163f6" name="LogPow_pKa_TriproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="4c531a91-b6a1-459c-8aea-770e63b51db0" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -433,7 +508,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="af8fe939-283d-4e79-a95e-7e474a8b6a29" name="LogPow_pKa_TriproticBase" persistable="0" isFixedValue="0" formula="ff563a68-283c-4c8c-a79b-6e78d4a1f66e" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="af8fe939-283d-4e79-a95e-7e474a8b6a29" name="LogPow_pKa_TriproticBase" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ff563a68-283c-4c8c-a79b-6e78d4a1f66e" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -441,7 +518,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="25451e0a-b74b-476e-99c7-449902174093" name="Fraction unbound (tissue)" persistable="0" isFixedValue="0" formula="32914bcc-8b33-446c-9043-1570f276bdfc" dim="Fraction" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="25451e0a-b74b-476e-99c7-449902174093" name="Fraction unbound (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="32914bcc-8b33-446c-9043-1570f276bdfc" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="Neighborhood: Interstitial / Intracellular" />
@@ -451,7 +530,7 @@
           </HelpParameters>
           <FormulaCache>
             <Formulas>
-              <Formula id="c7dfd783-7f09-4cc0-b912-5a8192058b10" name="PARAM_LogP_ow_pKa" dim="Dimensionless" formula="LogPow_pKa_Neutral + LogPow_pKa_MonoproticBase + LogPow_pKa_MonoproticAcid + LogPow_pKa_DiproticBase + LogPow_pKa_DiproticAcid + LogPow_pKa_MonoproticBaseMonoproticAcid + LogPow_pKa_TriproticAcid + LogPow_pKa_TriproticBase + LogPow_pKa_DiproticBaseMonoproticAcid + LogPow_pKa_MonoproticBaseDiproticAcid">
+              <Formula id="c7dfd783-7f09-4cc0-b912-5a8192058b10" name="PARAM_LogP_ow_pKa" formula="LogPow_pKa_Neutral + LogPow_pKa_MonoproticBase + LogPow_pKa_MonoproticAcid + LogPow_pKa_DiproticBase + LogPow_pKa_DiproticAcid + LogPow_pKa_MonoproticBaseMonoproticAcid + LogPow_pKa_TriproticAcid + LogPow_pKa_TriproticBase + LogPow_pKa_DiproticBaseMonoproticAcid + LogPow_pKa_MonoproticBaseDiproticAcid">
                 <Paths>
                   <Path path="31" as="32" />
                   <Path path="33" as="34" />
@@ -465,13 +544,13 @@
                   <Path path="49" as="50" />
                 </Paths>
               </Formula>
-              <Formula id="693e6dfa-5603-4b70-9ccc-185670132546" name="PARAM_LogP_ow" dim="Lipophilicity" formula="1.115 * LogP - 1.35 - LogP_ow_pKa">
+              <Formula id="693e6dfa-5603-4b70-9ccc-185670132546" name="PARAM_LogP_ow" dim="Log Units" formula="1.115 * LogP - 1.35 - LogP_ow_pKa">
                 <Paths>
                   <Path path="3" as="16" dim="5" />
                   <Path path="51" as="52" />
                 </Paths>
               </Formula>
-              <Formula id="9641e3e4-ced3-40f8-866c-31c57fa330ea" name="PARAM_LogPow_pKa_DiproticAcid" dim="Dimensionless" formula="IsDiproticAcid ? Log10(1+10^(2*pH_PLS-pKa_Acid_0-pKa_Acid_1)) : 0">
+              <Formula id="9641e3e4-ced3-40f8-866c-31c57fa330ea" name="PARAM_LogPow_pKa_DiproticAcid" formula="IsDiproticAcid ? Log10(1+10^(2*pH_PLS-pKa_Acid_0-pKa_Acid_1)) : 0">
                 <Paths>
                   <Path path="53" as="54" />
                   <Path path="55" as="56" />
@@ -479,7 +558,7 @@
                   <Path path="59" as="60" />
                 </Paths>
               </Formula>
-              <Formula id="00f63719-e5f2-4f6f-ad3d-f99bce65d360" name="PARAM_LogPow_pKa_DiproticBase" dim="Dimensionless" formula="IsDiproticBase ? Log10(1+10^(pKa_Base_0+pKa_Base_1-2*pH_PLS)) : 0">
+              <Formula id="00f63719-e5f2-4f6f-ad3d-f99bce65d360" name="PARAM_LogPow_pKa_DiproticBase" formula="IsDiproticBase ? Log10(1+10^(pKa_Base_0+pKa_Base_1-2*pH_PLS)) : 0">
                 <Paths>
                   <Path path="61" as="62" />
                   <Path path="63" as="64" />
@@ -487,7 +566,7 @@
                   <Path path="59" as="60" />
                 </Paths>
               </Formula>
-              <Formula id="6fb245f2-8403-4b03-8045-4caa27d8bb36" name="PARAM_LogPow_pKa_DiproticBaseMonoproticAcid" dim="Dimensionless" formula="IsDiproticBaseMonoproticAcid ? Log10(1+10^(pKa_Base_0+pKa_Base_1-pKa_Acid_0-pH_PLS)) : 0">
+              <Formula id="6fb245f2-8403-4b03-8045-4caa27d8bb36" name="PARAM_LogPow_pKa_DiproticBaseMonoproticAcid" formula="IsDiproticBaseMonoproticAcid ? Log10(1+10^(pKa_Base_0+pKa_Base_1-pKa_Acid_0-pH_PLS)) : 0">
                 <Paths>
                   <Path path="67" as="68" />
                   <Path path="55" as="56" />
@@ -496,21 +575,21 @@
                   <Path path="59" as="60" />
                 </Paths>
               </Formula>
-              <Formula id="bdb0eb0c-242a-4064-b643-63ef739548a1" name="PARAM_LogPow_pKa_MonoproticAcid" dim="Dimensionless" formula="IsMonoproticAcid ? Log10(1+10^(pH_PLS-pKa_Acid_0)) : 0">
+              <Formula id="bdb0eb0c-242a-4064-b643-63ef739548a1" name="PARAM_LogPow_pKa_MonoproticAcid" formula="IsMonoproticAcid ? Log10(1+10^(pH_PLS-pKa_Acid_0)) : 0">
                 <Paths>
                   <Path path="69" as="70" />
                   <Path path="55" as="56" />
                   <Path path="59" as="60" />
                 </Paths>
               </Formula>
-              <Formula id="51dbb44a-af66-403b-a335-114b606f2051" name="PARAM_LogPow_pKa_MonoproticBase" dim="Dimensionless" formula="IsMonoproticBase ? Log10(1+10^(pKa_Base_0-pH_PLS)) : 0">
+              <Formula id="51dbb44a-af66-403b-a335-114b606f2051" name="PARAM_LogPow_pKa_MonoproticBase" formula="IsMonoproticBase ? Log10(1+10^(pKa_Base_0-pH_PLS)) : 0">
                 <Paths>
                   <Path path="71" as="72" />
                   <Path path="63" as="64" />
                   <Path path="59" as="60" />
                 </Paths>
               </Formula>
-              <Formula id="46587d58-bf23-4cba-8295-bbb529bdad10" name="PARAM_LogPow_pKa_MonoproticBaseDiproticAcid" dim="Dimensionless" formula="IsMonoproticBaseDiproticAcid ? Log10(1+10^(pH_PLS-pKa_Acid_0-pKa_Acid_1+pKa_Base_0)) : 0">
+              <Formula id="46587d58-bf23-4cba-8295-bbb529bdad10" name="PARAM_LogPow_pKa_MonoproticBaseDiproticAcid" formula="IsMonoproticBaseDiproticAcid ? Log10(1+10^(pH_PLS-pKa_Acid_0-pKa_Acid_1+pKa_Base_0)) : 0">
                 <Paths>
                   <Path path="73" as="74" />
                   <Path path="55" as="56" />
@@ -519,7 +598,7 @@
                   <Path path="59" as="60" />
                 </Paths>
               </Formula>
-              <Formula id="a0dd64cf-25ee-4847-8509-5cc650d56702" name="PARAM_LogPow_pKa_MonoproticBaseMonoproticAcid" dim="Dimensionless" formula="IsMonoproticBaseMonoproticAcid ? Log10(1+10^(pKa_Base_0-pKa_Acid_0)) : 0">
+              <Formula id="a0dd64cf-25ee-4847-8509-5cc650d56702" name="PARAM_LogPow_pKa_MonoproticBaseMonoproticAcid" formula="IsMonoproticBaseMonoproticAcid ? Log10(1+10^(pKa_Base_0-pKa_Acid_0)) : 0">
                 <Paths>
                   <Path path="75" as="76" />
                   <Path path="55" as="56" />
@@ -527,7 +606,7 @@
                   <Path path="59" as="60" />
                 </Paths>
               </Formula>
-              <Formula id="4c531a91-b6a1-459c-8aea-770e63b51db0" name="PARAM_LogPow_pKa_TriproticAcid" dim="Dimensionless" formula="IsTriproticAcid ? Log10(1+10^(3*pH_PLS-pKa_Acid_0-pKa_Acid_1-pKa_Acid_2)) : 0">
+              <Formula id="4c531a91-b6a1-459c-8aea-770e63b51db0" name="PARAM_LogPow_pKa_TriproticAcid" formula="IsTriproticAcid ? Log10(1+10^(3*pH_PLS-pKa_Acid_0-pKa_Acid_1-pKa_Acid_2)) : 0">
                 <Paths>
                   <Path path="77" as="78" />
                   <Path path="55" as="56" />
@@ -536,7 +615,7 @@
                   <Path path="59" as="60" />
                 </Paths>
               </Formula>
-              <Formula id="ff563a68-283c-4c8c-a79b-6e78d4a1f66e" name="PARAM_LogPow_pKa_TriproticBase" dim="Dimensionless" formula="IsTriproticBase ? Log10(1+10^(pKa_Base_0+pKa_Base_1+pKa_Base_2-3*pH_PLS)) : 0">
+              <Formula id="ff563a68-283c-4c8c-a79b-6e78d4a1f66e" name="PARAM_LogPow_pKa_TriproticBase" formula="IsTriproticBase ? Log10(1+10^(pKa_Base_0+pKa_Base_1+pKa_Base_2-3*pH_PLS)) : 0">
                 <Paths>
                   <Path path="81" as="82" />
                   <Path path="63" as="64" />
@@ -551,7 +630,6 @@
                   <Path path="85" as="86" />
                 </Paths>
               </Formula>
-              <ConstantFormula id="f17df6cc-5bd8-43e9-8439-71a0f458b91a" dim="Dimensionless" value="0" />
             </Formulas>
             <StringMap>
               <Map s="MOLECULE|Fraction unbound (plasma)" id="0" />
@@ -559,7 +637,7 @@
               <Map s="Fraction" id="2" />
               <Map s="MOLECULE|Lipophilicity" id="3" />
               <Map s="LogMA" id="4" />
-              <Map s="Lipophilicity" id="5" />
+              <Map s="Log Units" id="5" />
               <Map s="MOLECULE|Partition coefficient (water/protein)" id="6" />
               <Map s="KProt" id="7" />
               <Map s="Organism|Vf (lipid, blood cells)" id="8" />
@@ -644,10 +722,11 @@
             </StringMap>
           </FormulaCache>
         </CoreCalculationMethod>
-        <CoreCalculationMethod id="4036f981-0f55-474e-9275-247ddb7504e6" name="Cellular partition coefficient method - PK-Sim Standard" category="DistributionCellular">
+        <CoreCalculationMethod id="4036f981-0f55-474e-9275-247ddb7504e6" name="Cellular partition coefficient method - PK-Sim Standard" icon="CoreCalculationMethod" bbVersion="0" category="DistributionCellular">
+          <Creation createdAt="5248846133421152833" createdBy="Michael" creationMode="New" origin="Other" />
           <OutputFormulas>
             <KeyValue>
-              <Formula id="d2a58301-e23c-4c7a-9b52-a22dc67e0f8e" name="PARAM_K_rbc" dim="Dimensionless" formula="(f_water_rbc + f_lipids_rbc * 10^LogMA + f_proteins_rbc * KProt)*fu">
+              <Formula id="d2a58301-e23c-4c7a-9b52-a22dc67e0f8e" name="PARAM_K_rbc" formula="(f_water_rbc + f_lipids_rbc * 10^LogMA + f_proteins_rbc * KProt)*fu">
                 <Paths>
                   <Path path="0" as="1" dim="2" />
                   <Path path="3" as="4" dim="5" />
@@ -666,7 +745,7 @@
               </ParameterDescriptor>
             </KeyValue>
             <KeyValue>
-              <Formula id="644b0466-4743-470d-9ad4-8d27e3e08400" name="PARAM_K_cell_pls_PK-Sim_Standard" dim="Dimensionless" formula="(f_water + f_lipids * 10^LogMA + f_proteins * KProt) * fu">
+              <Formula id="644b0466-4743-470d-9ad4-8d27e3e08400" name="PARAM_K_cell_pls_PK-Sim_Standard" formula="(f_water + f_lipids * 10^LogMA + f_proteins * KProt) * fu">
                 <Paths>
                   <Path path="0" as="1" dim="2" />
                   <Path path="3" as="4" dim="5" />
@@ -693,7 +772,7 @@
               <Map s="Fraction" id="2" />
               <Map s="MOLECULE|Lipophilicity" id="3" />
               <Map s="LogMA" id="4" />
-              <Map s="Lipophilicity" id="5" />
+              <Map s="Log Units" id="5" />
               <Map s="MOLECULE|Partition coefficient (water/protein)" id="6" />
               <Map s="KProt" id="7" />
               <Map s="Organism|Vf (lipid, blood cells)" id="8" />
@@ -711,10 +790,11 @@
             </StringMap>
           </FormulaCache>
         </CoreCalculationMethod>
-        <CoreCalculationMethod id="5d601fc8-3c6b-4ac6-8f39-da9e4eda8039" name="Cellular partition coefficient method - Poulin and Theil" category="DistributionCellular">
+        <CoreCalculationMethod id="5d601fc8-3c6b-4ac6-8f39-da9e4eda8039" name="Cellular partition coefficient method - Poulin and Theil" icon="CoreCalculationMethod" bbVersion="0" category="DistributionCellular">
+          <Creation createdAt="5248846133421162846" createdBy="Michael" creationMode="New" origin="Other" />
           <OutputFormulas>
             <KeyValue>
-              <Formula id="a1479059-2fd1-4b55-a49c-67da1f6a551e" name="PARAM_K_rbc" dim="Dimensionless" formula="(f_water_rbc + f_lipids_rbc * 10^LogMA + f_proteins_rbc * KProt)*fu">
+              <Formula id="a1479059-2fd1-4b55-a49c-67da1f6a551e" name="PARAM_K_rbc" formula="(f_water_rbc + f_lipids_rbc * 10^LogMA + f_proteins_rbc * KProt)*fu">
                 <Paths>
                   <Path path="0" as="1" dim="2" />
                   <Path path="3" as="4" dim="5" />
@@ -733,7 +813,7 @@
               </ParameterDescriptor>
             </KeyValue>
             <KeyValue>
-              <Formula id="cd0e1be5-ff83-4cb1-a56a-e5e50369e633" name="PARAM_K_cell_pls_Poulin_and_Theil" dim="Dimensionless" formula="(10^LogP * (V_nlt + 0.3 * V_pht) +  0.7 * V_pht + V_wt) / (10^LogP * (V_nlp + 0.3 * V_php) +  0.7 * V_php + V_wp) * (fu / fu_t)  ">
+              <Formula id="cd0e1be5-ff83-4cb1-a56a-e5e50369e633" name="PARAM_K_cell_pls_Poulin_and_Theil" formula="(10^LogP * (V_nlt + 0.3 * V_pht) +  0.7 * V_pht + V_wt) / (10^LogP * (V_nlp + 0.3 * V_php) +  0.7 * V_php + V_wp) * (fu / fu_t)  ">
                 <Paths>
                   <Path path="14" as="15" dim="2" />
                   <Path path="0" as="1" dim="2" />
@@ -756,7 +836,7 @@
               </ParameterDescriptor>
             </KeyValue>
             <KeyValue>
-              <Formula id="bc2497b9-1765-4d80-b562-d621b859bfc3" name="PARAM_K_cell_pls_fat" dim="Dimensionless" formula="(10^LogP_ow * (V_nlt + 0.3 * V_pht) +  0.7 * V_pht + V_wt) / (10^LogP_ow * (V_nlp + 0.3 * V_php) +  0.7 * V_php + V_wp) * (fu / fu_t)">
+              <Formula id="bc2497b9-1765-4d80-b562-d621b859bfc3" name="PARAM_K_cell_pls_fat" formula="(10^LogP_ow * (V_nlt + 0.3 * V_pht) +  0.7 * V_pht + V_wt) / (10^LogP_ow * (V_nlp + 0.3 * V_php) +  0.7 * V_php + V_wp) * (fu / fu_t)">
                 <Paths>
                   <Path path="14" as="15" dim="2" />
                   <Path path="0" as="1" dim="2" />
@@ -781,7 +861,9 @@
           </OutputFormulas>
           <HelpParameters>
             <KeyValue>
-              <Parameter id="075aa19d-ff53-4ec8-9558-c02369b3ee7b" name="logP (oil/water,pKa)" persistable="0" isFixedValue="0" formula="18f2afd2-ed2c-45b5-a9b2-ee06d936a5d4" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="075aa19d-ff53-4ec8-9558-c02369b3ee7b" name="logP (oil/water,pKa)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="18f2afd2-ed2c-45b5-a9b2-ee06d936a5d4" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -789,7 +871,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="bdffc9e0-31a3-4bad-afee-cca7f78490e6" name="logP (veg.oil/water)" persistable="0" isFixedValue="0" formula="2c5ce0d5-769e-457e-a1e8-8af6ed857719" dim="Lipophilicity" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="bdffc9e0-31a3-4bad-afee-cca7f78490e6" name="logP (veg.oil/water)" icon="Parameter" persistable="0" isFixedValue="0" dim="Log Units" quantityType="Parameter" negativeValuesAllowed="1" formula="2c5ce0d5-769e-457e-a1e8-8af6ed857719" isDefault="0" displayUnit="Log Units">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -797,7 +881,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="7fa3aa27-426d-47c3-b1a9-38851e066f7a" name="LogPow_pKa_DiproticAcid" persistable="0" isFixedValue="0" formula="298895e2-3a56-4a15-9932-b38f9a67be46" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="7fa3aa27-426d-47c3-b1a9-38851e066f7a" name="LogPow_pKa_DiproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="298895e2-3a56-4a15-9932-b38f9a67be46" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -805,7 +891,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="e359e526-6bff-4cf4-922f-2a2c0cdc7a6e" name="LogPow_pKa_DiproticBase" persistable="0" isFixedValue="0" formula="f35f614c-684c-4347-82a4-77c3ae0514c5" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="e359e526-6bff-4cf4-922f-2a2c0cdc7a6e" name="LogPow_pKa_DiproticBase" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="f35f614c-684c-4347-82a4-77c3ae0514c5" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -813,7 +901,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="0d6a11ea-414c-410b-85b7-0f569262c78f" name="LogPow_pKa_DiproticBaseMonoproticAcid" persistable="0" isFixedValue="0" formula="ec1ffe1a-48f2-4b68-8cca-288c02937012" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="0d6a11ea-414c-410b-85b7-0f569262c78f" name="LogPow_pKa_DiproticBaseMonoproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ec1ffe1a-48f2-4b68-8cca-288c02937012" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -821,7 +911,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="29b541b8-5a0b-455b-8f6a-854cd827f654" name="LogPow_pKa_MonoproticAcid" persistable="0" isFixedValue="0" formula="b5be9702-4c18-4a47-8c6e-7441a50ac3e6" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="29b541b8-5a0b-455b-8f6a-854cd827f654" name="LogPow_pKa_MonoproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="b5be9702-4c18-4a47-8c6e-7441a50ac3e6" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -829,7 +921,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="db6444da-1ed4-4a7c-9208-de35f5b6d4ba" name="LogPow_pKa_MonoproticBase" persistable="0" isFixedValue="0" formula="0415580b-786d-4e91-8787-dd5bfe6b043d" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="db6444da-1ed4-4a7c-9208-de35f5b6d4ba" name="LogPow_pKa_MonoproticBase" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="0415580b-786d-4e91-8787-dd5bfe6b043d" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -837,7 +931,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="a79ec396-b8e2-40d6-bf59-de5e74a21dbd" name="LogPow_pKa_MonoproticBaseDiproticAcid" persistable="0" isFixedValue="0" formula="08b71ae2-cc27-4020-b097-6e1cb32d69af" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="a79ec396-b8e2-40d6-bf59-de5e74a21dbd" name="LogPow_pKa_MonoproticBaseDiproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="08b71ae2-cc27-4020-b097-6e1cb32d69af" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -845,7 +941,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="c82efc18-5ca8-4c92-8dc8-4205a802caaa" name="LogPow_pKa_MonoproticBaseMonoproticAcid" persistable="0" isFixedValue="0" formula="645f1e58-f32e-4a98-b52d-02debd81c47f" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="c82efc18-5ca8-4c92-8dc8-4205a802caaa" name="LogPow_pKa_MonoproticBaseMonoproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="645f1e58-f32e-4a98-b52d-02debd81c47f" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -853,7 +951,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="20c985b5-326e-4710-a4d9-d3d738ec36ac" name="LogPow_pKa_Neutral" persistable="0" isFixedValue="0" formula="23969bde-7d79-4c54-bdd3-94f66a213a4c" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="20c985b5-326e-4710-a4d9-d3d738ec36ac" name="LogPow_pKa_Neutral" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="0" value="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -861,7 +961,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="d2844ca7-3fea-4f6f-96df-a2a188976ef6" name="LogPow_pKa_TriproticAcid" persistable="0" isFixedValue="0" formula="069aa616-a656-4cb6-b52f-bc7be0e9aba8" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="d2844ca7-3fea-4f6f-96df-a2a188976ef6" name="LogPow_pKa_TriproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="069aa616-a656-4cb6-b52f-bc7be0e9aba8" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -869,7 +971,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="03c4e7e2-4947-4d78-bbd2-561e8c12bccf" name="LogPow_pKa_TriproticBase" persistable="0" isFixedValue="0" formula="5800aafc-f3f6-4881-acf9-ea4ad084625c" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="03c4e7e2-4947-4d78-bbd2-561e8c12bccf" name="LogPow_pKa_TriproticBase" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="5800aafc-f3f6-4881-acf9-ea4ad084625c" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -877,7 +981,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="6eb9a08b-9883-4ab2-8680-efd66c115ff9" name="Fraction unbound (tissue)" persistable="0" isFixedValue="0" formula="84b7e6ac-3ebb-451d-b78f-93a82196762e" dim="Fraction" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="6eb9a08b-9883-4ab2-8680-efd66c115ff9" name="Fraction unbound (tissue)" icon="Parameter" persistable="0" isFixedValue="0" dim="Fraction" quantityType="Parameter" negativeValuesAllowed="1" formula="84b7e6ac-3ebb-451d-b78f-93a82196762e" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="Neighborhood: Interstitial / Intracellular" />
@@ -887,7 +993,7 @@
           </HelpParameters>
           <FormulaCache>
             <Formulas>
-              <Formula id="18f2afd2-ed2c-45b5-a9b2-ee06d936a5d4" name="PARAM_LogP_ow_pKa" dim="Dimensionless" formula="LogPow_pKa_Neutral + LogPow_pKa_MonoproticBase + LogPow_pKa_MonoproticAcid + LogPow_pKa_DiproticBase + LogPow_pKa_DiproticAcid + LogPow_pKa_MonoproticBaseMonoproticAcid + LogPow_pKa_TriproticAcid + LogPow_pKa_TriproticBase + LogPow_pKa_DiproticBaseMonoproticAcid + LogPow_pKa_MonoproticBaseDiproticAcid">
+              <Formula id="18f2afd2-ed2c-45b5-a9b2-ee06d936a5d4" name="PARAM_LogP_ow_pKa" formula="LogPow_pKa_Neutral + LogPow_pKa_MonoproticBase + LogPow_pKa_MonoproticAcid + LogPow_pKa_DiproticBase + LogPow_pKa_DiproticAcid + LogPow_pKa_MonoproticBaseMonoproticAcid + LogPow_pKa_TriproticAcid + LogPow_pKa_TriproticBase + LogPow_pKa_DiproticBaseMonoproticAcid + LogPow_pKa_MonoproticBaseDiproticAcid">
                 <Paths>
                   <Path path="31" as="32" />
                   <Path path="33" as="34" />
@@ -901,13 +1007,13 @@
                   <Path path="49" as="50" />
                 </Paths>
               </Formula>
-              <Formula id="2c5ce0d5-769e-457e-a1e8-8af6ed857719" name="PARAM_LogP_ow" dim="Lipophilicity" formula="1.115 * LogP - 1.35 - LogP_ow_pKa">
+              <Formula id="2c5ce0d5-769e-457e-a1e8-8af6ed857719" name="PARAM_LogP_ow" dim="Log Units" formula="1.115 * LogP - 1.35 - LogP_ow_pKa">
                 <Paths>
                   <Path path="3" as="16" dim="5" />
                   <Path path="51" as="52" />
                 </Paths>
               </Formula>
-              <Formula id="298895e2-3a56-4a15-9932-b38f9a67be46" name="PARAM_LogPow_pKa_DiproticAcid" dim="Dimensionless" formula="IsDiproticAcid ? Log10(1+10^(2*pH_PLS-pKa_Acid_0-pKa_Acid_1)) : 0">
+              <Formula id="298895e2-3a56-4a15-9932-b38f9a67be46" name="PARAM_LogPow_pKa_DiproticAcid" formula="IsDiproticAcid ? Log10(1+10^(2*pH_PLS-pKa_Acid_0-pKa_Acid_1)) : 0">
                 <Paths>
                   <Path path="53" as="54" />
                   <Path path="55" as="56" />
@@ -915,7 +1021,7 @@
                   <Path path="59" as="60" />
                 </Paths>
               </Formula>
-              <Formula id="f35f614c-684c-4347-82a4-77c3ae0514c5" name="PARAM_LogPow_pKa_DiproticBase" dim="Dimensionless" formula="IsDiproticBase ? Log10(1+10^(pKa_Base_0+pKa_Base_1-2*pH_PLS)) : 0">
+              <Formula id="f35f614c-684c-4347-82a4-77c3ae0514c5" name="PARAM_LogPow_pKa_DiproticBase" formula="IsDiproticBase ? Log10(1+10^(pKa_Base_0+pKa_Base_1-2*pH_PLS)) : 0">
                 <Paths>
                   <Path path="61" as="62" />
                   <Path path="63" as="64" />
@@ -923,7 +1029,7 @@
                   <Path path="59" as="60" />
                 </Paths>
               </Formula>
-              <Formula id="ec1ffe1a-48f2-4b68-8cca-288c02937012" name="PARAM_LogPow_pKa_DiproticBaseMonoproticAcid" dim="Dimensionless" formula="IsDiproticBaseMonoproticAcid ? Log10(1+10^(pKa_Base_0+pKa_Base_1-pKa_Acid_0-pH_PLS)) : 0">
+              <Formula id="ec1ffe1a-48f2-4b68-8cca-288c02937012" name="PARAM_LogPow_pKa_DiproticBaseMonoproticAcid" formula="IsDiproticBaseMonoproticAcid ? Log10(1+10^(pKa_Base_0+pKa_Base_1-pKa_Acid_0-pH_PLS)) : 0">
                 <Paths>
                   <Path path="67" as="68" />
                   <Path path="55" as="56" />
@@ -932,21 +1038,21 @@
                   <Path path="59" as="60" />
                 </Paths>
               </Formula>
-              <Formula id="b5be9702-4c18-4a47-8c6e-7441a50ac3e6" name="PARAM_LogPow_pKa_MonoproticAcid" dim="Dimensionless" formula="IsMonoproticAcid ? Log10(1+10^(pH_PLS-pKa_Acid_0)) : 0">
+              <Formula id="b5be9702-4c18-4a47-8c6e-7441a50ac3e6" name="PARAM_LogPow_pKa_MonoproticAcid" formula="IsMonoproticAcid ? Log10(1+10^(pH_PLS-pKa_Acid_0)) : 0">
                 <Paths>
                   <Path path="69" as="70" />
                   <Path path="55" as="56" />
                   <Path path="59" as="60" />
                 </Paths>
               </Formula>
-              <Formula id="0415580b-786d-4e91-8787-dd5bfe6b043d" name="PARAM_LogPow_pKa_MonoproticBase" dim="Dimensionless" formula="IsMonoproticBase ? Log10(1+10^(pKa_Base_0-pH_PLS)) : 0">
+              <Formula id="0415580b-786d-4e91-8787-dd5bfe6b043d" name="PARAM_LogPow_pKa_MonoproticBase" formula="IsMonoproticBase ? Log10(1+10^(pKa_Base_0-pH_PLS)) : 0">
                 <Paths>
                   <Path path="71" as="72" />
                   <Path path="63" as="64" />
                   <Path path="59" as="60" />
                 </Paths>
               </Formula>
-              <Formula id="08b71ae2-cc27-4020-b097-6e1cb32d69af" name="PARAM_LogPow_pKa_MonoproticBaseDiproticAcid" dim="Dimensionless" formula="IsMonoproticBaseDiproticAcid ? Log10(1+10^(pH_PLS-pKa_Acid_0-pKa_Acid_1+pKa_Base_0)) : 0">
+              <Formula id="08b71ae2-cc27-4020-b097-6e1cb32d69af" name="PARAM_LogPow_pKa_MonoproticBaseDiproticAcid" formula="IsMonoproticBaseDiproticAcid ? Log10(1+10^(pH_PLS-pKa_Acid_0-pKa_Acid_1+pKa_Base_0)) : 0">
                 <Paths>
                   <Path path="73" as="74" />
                   <Path path="55" as="56" />
@@ -955,7 +1061,7 @@
                   <Path path="59" as="60" />
                 </Paths>
               </Formula>
-              <Formula id="645f1e58-f32e-4a98-b52d-02debd81c47f" name="PARAM_LogPow_pKa_MonoproticBaseMonoproticAcid" dim="Dimensionless" formula="IsMonoproticBaseMonoproticAcid ? Log10(1+10^(pKa_Base_0-pKa_Acid_0)) : 0">
+              <Formula id="645f1e58-f32e-4a98-b52d-02debd81c47f" name="PARAM_LogPow_pKa_MonoproticBaseMonoproticAcid" formula="IsMonoproticBaseMonoproticAcid ? Log10(1+10^(pKa_Base_0-pKa_Acid_0)) : 0">
                 <Paths>
                   <Path path="75" as="76" />
                   <Path path="55" as="56" />
@@ -963,7 +1069,7 @@
                   <Path path="59" as="60" />
                 </Paths>
               </Formula>
-              <Formula id="069aa616-a656-4cb6-b52f-bc7be0e9aba8" name="PARAM_LogPow_pKa_TriproticAcid" dim="Dimensionless" formula="IsTriproticAcid ? Log10(1+10^(3*pH_PLS-pKa_Acid_0-pKa_Acid_1-pKa_Acid_2)) : 0">
+              <Formula id="069aa616-a656-4cb6-b52f-bc7be0e9aba8" name="PARAM_LogPow_pKa_TriproticAcid" formula="IsTriproticAcid ? Log10(1+10^(3*pH_PLS-pKa_Acid_0-pKa_Acid_1-pKa_Acid_2)) : 0">
                 <Paths>
                   <Path path="77" as="78" />
                   <Path path="55" as="56" />
@@ -972,7 +1078,7 @@
                   <Path path="59" as="60" />
                 </Paths>
               </Formula>
-              <Formula id="5800aafc-f3f6-4881-acf9-ea4ad084625c" name="PARAM_LogPow_pKa_TriproticBase" dim="Dimensionless" formula="IsTriproticBase ? Log10(1+10^(pKa_Base_0+pKa_Base_1+pKa_Base_2-3*pH_PLS)) : 0">
+              <Formula id="5800aafc-f3f6-4881-acf9-ea4ad084625c" name="PARAM_LogPow_pKa_TriproticBase" formula="IsTriproticBase ? Log10(1+10^(pKa_Base_0+pKa_Base_1+pKa_Base_2-3*pH_PLS)) : 0">
                 <Paths>
                   <Path path="81" as="82" />
                   <Path path="63" as="64" />
@@ -987,7 +1093,6 @@
                   <Path path="85" as="86" />
                 </Paths>
               </Formula>
-              <ConstantFormula id="23969bde-7d79-4c54-bdd3-94f66a213a4c" dim="Dimensionless" value="0" />
             </Formulas>
             <StringMap>
               <Map s="MOLECULE|Fraction unbound (plasma)" id="0" />
@@ -995,7 +1100,7 @@
               <Map s="Fraction" id="2" />
               <Map s="MOLECULE|Lipophilicity" id="3" />
               <Map s="LogMA" id="4" />
-              <Map s="Lipophilicity" id="5" />
+              <Map s="Log Units" id="5" />
               <Map s="MOLECULE|Partition coefficient (water/protein)" id="6" />
               <Map s="KProt" id="7" />
               <Map s="Organism|Vf (lipid, blood cells)" id="8" />
@@ -1080,10 +1185,11 @@
             </StringMap>
           </FormulaCache>
         </CoreCalculationMethod>
-        <CoreCalculationMethod id="a674fe84-bb2e-4e01-aa83-790e0cafeb85" name="Cellular partition coefficient method - Rodgers and Rowland" category="DistributionCellular">
+        <CoreCalculationMethod id="a674fe84-bb2e-4e01-aa83-790e0cafeb85" name="Cellular partition coefficient method - Rodgers and Rowland" icon="CoreCalculationMethod" bbVersion="0" category="DistributionCellular">
+          <Creation createdAt="5248846133421172764" createdBy="Michael" creationMode="New" origin="Other" />
           <OutputFormulas>
             <KeyValue>
-              <Formula id="a6a32b00-642f-427a-8fb3-6463ec2a047c" name="PARAM_K_rbc" dim="Dimensionless" formula="K_pu_bc*fu">
+              <Formula id="a6a32b00-642f-427a-8fb3-6463ec2a047c" name="PARAM_K_rbc" formula="K_pu_bc*fu">
                 <Paths>
                   <Path path="0" as="1" dim="2" />
                   <Path path="3" as="4" />
@@ -1098,7 +1204,7 @@
               </ParameterDescriptor>
             </KeyValue>
             <KeyValue>
-              <Formula id="efc6856e-2942-450f-a802-9ae290210366" name="PARAM_K_cell_pls_Rodgers_and_Rowland" dim="Dimensionless" formula="((1+X)/(1+Y)*f_iw + f_ew + (10^LogP*f_nl+(0.3*10^LogP+0.7)*f_np)/(1+Y) + (HasStrongBase ? Ka_AP*AP_T*X/(1+Y) : Ka_PR*(IsNeutral ? PR_T2PR_P_Lipoprotein : PR_T2PR_P_Albumin)))*fu">
+              <Formula id="efc6856e-2942-450f-a802-9ae290210366" name="PARAM_K_cell_pls_Rodgers_and_Rowland" formula="((1+X)/(1+Y)*f_iw + f_ew + (10^LogP*f_nl+(0.3*10^LogP+0.7)*f_np)/(1+Y) + (HasStrongBase ? Ka_AP*AP_T*X/(1+Y) : Ka_PR*(IsNeutral ? PR_T2PR_P_Lipoprotein : PR_T2PR_P_Albumin)))*fu">
                 <Paths>
                   <Path path="0" as="1" dim="2" />
                   <Path path="5" as="6" />
@@ -1127,7 +1233,7 @@
               </ParameterDescriptor>
             </KeyValue>
             <KeyValue>
-              <Formula id="f5a7c23f-0731-4235-8eef-56cf630d33b9" name="PARAM_K_cell_pls_fat" dim="Dimensionless" formula="((1+X)/(1+Y)*f_iw + f_ew + (10^LogP_ow*f_nl+(0.3*10^LogP_ow+0.7)*f_np)/(1+Y) + (HasStrongBase ? Ka_AP*AP_T*X/(1+Y) : Ka_PR*(IsNeutral ? PR_T2PR_P_Lipoprotein : PR_T2PR_P_Albumin)))*fu">
+              <Formula id="f5a7c23f-0731-4235-8eef-56cf630d33b9" name="PARAM_K_cell_pls_fat" formula="((1+X)/(1+Y)*f_iw + f_ew + (10^LogP_ow*f_nl+(0.3*10^LogP_ow+0.7)*f_np)/(1+Y) + (HasStrongBase ? Ka_AP*AP_T*X/(1+Y) : Ka_PR*(IsNeutral ? PR_T2PR_P_Lipoprotein : PR_T2PR_P_Albumin)))*fu">
                 <Paths>
                   <Path path="0" as="1" dim="2" />
                   <Path path="5" as="6" />
@@ -1158,7 +1264,9 @@
           </OutputFormulas>
           <HelpParameters>
             <KeyValue>
-              <Parameter id="90f74151-7685-42a6-bed4-9ac0a8dc17ea" name="Blood/Plasma concentration ratio" persistable="0" isFixedValue="0" formula="ea3755a7-0e80-4ebf-bc01-f1ffaafd2af7" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="90f74151-7685-42a6-bed4-9ac0a8dc17ea" name="Blood/Plasma concentration ratio" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ea3755a7-0e80-4ebf-bc01-f1ffaafd2af7" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -1166,7 +1274,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="2a70f002-f13e-4bc7-8a37-db490714d5ad" name="Ka (acidic phospholipids)" persistable="0" isFixedValue="0" formula="75a33ebc-7c0e-4f8e-9b98-e7293d53e88e" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="2a70f002-f13e-4bc7-8a37-db490714d5ad" name="Ka (acidic phospholipids)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="75a33ebc-7c0e-4f8e-9b98-e7293d53e88e" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -1174,7 +1284,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="734256ff-61b3-4a04-a929-7eb8a5944459" name="Ka (proteins)" persistable="0" isFixedValue="0" formula="9bd5cadb-2949-4cc1-af4c-fcfebc8cbc20" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="734256ff-61b3-4a04-a929-7eb8a5944459" name="Ka (proteins)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="9bd5cadb-2949-4cc1-af4c-fcfebc8cbc20" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -1182,7 +1294,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="888a0a1f-5a00-4fab-a743-3ffbd914f554" name="logP (veg.oil/water)" persistable="0" isFixedValue="0" formula="3fab0b0f-ae2e-4705-ad32-c1f50a72a86f" dim="Lipophilicity" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="888a0a1f-5a00-4fab-a743-3ffbd914f554" name="logP (veg.oil/water)" icon="Parameter" persistable="0" isFixedValue="0" dim="Log Units" quantityType="Parameter" negativeValuesAllowed="1" formula="3fab0b0f-ae2e-4705-ad32-c1f50a72a86f" isDefault="0" displayUnit="Log Units">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -1190,7 +1304,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="2705e1b6-a72a-4067-9a91-9d52b228b2d2" name="Partition coefficient (blood cells/plasma unbound)" persistable="0" isFixedValue="0" formula="67c11811-d81b-449c-83a4-8c699bcb8359" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="2705e1b6-a72a-4067-9a91-9d52b228b2d2" name="Partition coefficient (blood cells/plasma unbound)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="67c11811-d81b-449c-83a4-8c699bcb8359" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -1198,7 +1314,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="748ff591-cf64-4d66-98fe-1392c8a08e70" name="X" persistable="0" isFixedValue="0" formula="14f1b76e-256d-440f-95cb-fcac8b48f587" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="748ff591-cf64-4d66-98fe-1392c8a08e70" name="X" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="14f1b76e-256d-440f-95cb-fcac8b48f587" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -1206,7 +1324,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="6b9cba7d-0894-42df-88b6-1005dd0335d4" name="X_DiproticAcid" persistable="0" isFixedValue="0" formula="f6f7a771-d3a9-4294-8cad-b2a441cdc1ec" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="6b9cba7d-0894-42df-88b6-1005dd0335d4" name="X_DiproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="f6f7a771-d3a9-4294-8cad-b2a441cdc1ec" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -1214,7 +1334,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="55b783a0-c7e4-42b0-ab09-c5c2876119a8" name="X_DiproticBase" persistable="0" isFixedValue="0" formula="ac515a71-8460-4b2a-a96f-86f250429b05" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="55b783a0-c7e4-42b0-ab09-c5c2876119a8" name="X_DiproticBase" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ac515a71-8460-4b2a-a96f-86f250429b05" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -1222,7 +1344,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="352eae51-ea6c-4a64-a1c9-5aa53339daa1" name="X_DiproticBaseMonoproticAcid" persistable="0" isFixedValue="0" formula="17e9787f-79ac-450e-b962-f9330abda669" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="352eae51-ea6c-4a64-a1c9-5aa53339daa1" name="X_DiproticBaseMonoproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="17e9787f-79ac-450e-b962-f9330abda669" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -1230,7 +1354,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="b5549f2b-5b38-4787-8fa7-062e1827634d" name="X_MonoproticAcid" persistable="0" isFixedValue="0" formula="12a1c436-fc5c-4d9c-8904-44e05298b24a" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="b5549f2b-5b38-4787-8fa7-062e1827634d" name="X_MonoproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="12a1c436-fc5c-4d9c-8904-44e05298b24a" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -1238,7 +1364,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="b82fc679-5fd4-4cfb-a7e2-2e720ca996ef" name="X_MonoproticBase" persistable="0" isFixedValue="0" formula="d568d014-5313-4416-aa98-4290b263d548" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="b82fc679-5fd4-4cfb-a7e2-2e720ca996ef" name="X_MonoproticBase" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="d568d014-5313-4416-aa98-4290b263d548" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -1246,7 +1374,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="0a15bb3d-622f-45bd-b110-197d01f350ba" name="X_MonoproticBaseDiproticAcid" persistable="0" isFixedValue="0" formula="24248a10-001a-4357-a618-0538332389c8" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="0a15bb3d-622f-45bd-b110-197d01f350ba" name="X_MonoproticBaseDiproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="24248a10-001a-4357-a618-0538332389c8" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -1254,7 +1384,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="bf67cb06-b1fb-41bd-af70-92136acd4e6e" name="X_MonoproticBaseMonoproticAcid" persistable="0" isFixedValue="0" formula="ab0844ac-799c-464c-896e-e8c23d60b2f4" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="bf67cb06-b1fb-41bd-af70-92136acd4e6e" name="X_MonoproticBaseMonoproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ab0844ac-799c-464c-896e-e8c23d60b2f4" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -1262,7 +1394,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="fb5de373-42d3-4da8-9771-e7a09f9b6bcf" name="X_Neutral" persistable="0" isFixedValue="0" formula="d86fa8be-a533-4c8e-bfb6-01453d6162e6" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="fb5de373-42d3-4da8-9771-e7a09f9b6bcf" name="X_Neutral" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="0" value="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -1270,7 +1404,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="2346279a-7678-4d21-b70c-42994c4ac9a6" name="X_TriproticAcid" persistable="0" isFixedValue="0" formula="da6f6c06-c7f1-4d4b-8df6-c5288af3e738" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="2346279a-7678-4d21-b70c-42994c4ac9a6" name="X_TriproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="da6f6c06-c7f1-4d4b-8df6-c5288af3e738" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -1278,7 +1414,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="56793386-3213-4646-ba01-5b2cca70e77e" name="X_TriproticBase" persistable="0" isFixedValue="0" formula="7497efa7-8e56-4da3-843d-d5ba678c07af" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="56793386-3213-4646-ba01-5b2cca70e77e" name="X_TriproticBase" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="7497efa7-8e56-4da3-843d-d5ba678c07af" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -1286,7 +1424,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="fbb8c2b1-8777-44a9-93ee-cf2b6298b586" name="Y" persistable="0" isFixedValue="0" formula="185aeac6-bf38-404e-8c68-14cb13d3b5f7" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="fbb8c2b1-8777-44a9-93ee-cf2b6298b586" name="Y" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="185aeac6-bf38-404e-8c68-14cb13d3b5f7" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -1294,7 +1434,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="bd1df873-9fff-44d4-9850-167e37411b7f" name="Y_DiproticAcid" persistable="0" isFixedValue="0" formula="0f1cb615-8f1c-41b7-9fa4-21820f00a920" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="bd1df873-9fff-44d4-9850-167e37411b7f" name="Y_DiproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="0f1cb615-8f1c-41b7-9fa4-21820f00a920" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -1302,7 +1444,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="bad820e5-0ff0-434f-a8ed-2b05573be6fc" name="Y_DiproticBase" persistable="0" isFixedValue="0" formula="c0b5bf89-46d7-4a37-a2a7-06a537d8e2a0" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="bad820e5-0ff0-434f-a8ed-2b05573be6fc" name="Y_DiproticBase" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="c0b5bf89-46d7-4a37-a2a7-06a537d8e2a0" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -1310,7 +1454,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="7052b525-c62e-4fe6-91be-a7ca787a9062" name="Y_DiproticBaseMonoproticAcid" persistable="0" isFixedValue="0" formula="b09b93e2-604f-4b17-bcaf-b8f1df487a1d" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="7052b525-c62e-4fe6-91be-a7ca787a9062" name="Y_DiproticBaseMonoproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="b09b93e2-604f-4b17-bcaf-b8f1df487a1d" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -1318,7 +1464,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="1ed190b0-fb7a-4ca9-b915-a8bc845c8a55" name="Y_MonoproticAcid" persistable="0" isFixedValue="0" formula="8eb1e423-aae0-4592-94a1-92e34f618187" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="1ed190b0-fb7a-4ca9-b915-a8bc845c8a55" name="Y_MonoproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="8eb1e423-aae0-4592-94a1-92e34f618187" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -1326,7 +1474,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="7382d1cc-9446-438a-ac77-32bd6def392c" name="Y_MonoproticBase" persistable="0" isFixedValue="0" formula="1dbc8692-7e74-4fee-8396-69e969b0f7e0" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="7382d1cc-9446-438a-ac77-32bd6def392c" name="Y_MonoproticBase" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="1dbc8692-7e74-4fee-8396-69e969b0f7e0" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -1334,7 +1484,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="3c2a7ab7-3892-47d7-8891-113916b884b3" name="Y_MonoproticBaseDiproticAcid" persistable="0" isFixedValue="0" formula="8a1a1950-f021-4acc-bac7-bee2e3b26816" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="3c2a7ab7-3892-47d7-8891-113916b884b3" name="Y_MonoproticBaseDiproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="8a1a1950-f021-4acc-bac7-bee2e3b26816" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -1342,7 +1494,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="bb2f4960-d66c-40d8-9912-a3b2d0780e05" name="Y_MonoproticBaseMonoproticAcid" persistable="0" isFixedValue="0" formula="3cbd4ff1-0b71-4c5a-802b-44733a2c38eb" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="bb2f4960-d66c-40d8-9912-a3b2d0780e05" name="Y_MonoproticBaseMonoproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="3cbd4ff1-0b71-4c5a-802b-44733a2c38eb" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -1350,7 +1504,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="c1923b92-0ae4-44fc-9840-044956c731b2" name="Y_Neutral" persistable="0" isFixedValue="0" formula="707899c5-e41a-4d7e-b7f7-cd9dad3b8628" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="c1923b92-0ae4-44fc-9840-044956c731b2" name="Y_Neutral" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" isDefault="0" value="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -1358,7 +1514,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="4e37959b-e2b3-4db1-9992-121c3626f101" name="Y_TriproticAcid" persistable="0" isFixedValue="0" formula="030aa1e0-9af5-4e91-b9dc-83c11e9109e6" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="4e37959b-e2b3-4db1-9992-121c3626f101" name="Y_TriproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="030aa1e0-9af5-4e91-b9dc-83c11e9109e6" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -1366,7 +1524,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="af8c97ce-d85a-4936-b9ad-19b38f9c0fb0" name="Y_TriproticBase" persistable="0" isFixedValue="0" formula="b71de829-5582-46f4-b66a-9f9e857eed32" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="af8c97ce-d85a-4936-b9ad-19b38f9c0fb0" name="Y_TriproticBase" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="b71de829-5582-46f4-b66a-9f9e857eed32" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -1374,7 +1534,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="e40fb5bf-31b6-44c4-81cf-989841d4c343" name="Z" persistable="0" isFixedValue="0" formula="0646e30d-a096-4d95-92ed-6d30fa89ced7" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="e40fb5bf-31b6-44c4-81cf-989841d4c343" name="Z" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="0646e30d-a096-4d95-92ed-6d30fa89ced7" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -1382,7 +1544,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="2224cd14-51eb-489f-8b26-2900d4c6651f" name="Z_DiproticAcid" persistable="0" isFixedValue="0" formula="a65a9097-1d4f-487e-9947-36c3e8c89292" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="2224cd14-51eb-489f-8b26-2900d4c6651f" name="Z_DiproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="a65a9097-1d4f-487e-9947-36c3e8c89292" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -1390,7 +1554,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="9ddd4ea8-ec70-452c-a8db-908a1899f1f9" name="Z_DiproticBase" persistable="0" isFixedValue="0" formula="ee412cc3-bdca-440c-886a-007a1a2b2ba9" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="9ddd4ea8-ec70-452c-a8db-908a1899f1f9" name="Z_DiproticBase" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ee412cc3-bdca-440c-886a-007a1a2b2ba9" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -1398,7 +1564,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="aec42691-5f41-4f06-9ee5-28d343af4ec5" name="Z_DiproticBaseMonoproticAcid" persistable="0" isFixedValue="0" formula="bb0a981c-ddad-4109-afbb-3f04273b0c48" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="aec42691-5f41-4f06-9ee5-28d343af4ec5" name="Z_DiproticBaseMonoproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="bb0a981c-ddad-4109-afbb-3f04273b0c48" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -1406,7 +1574,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="15f56ba9-0dd3-47bc-bbe9-58a04ad568cb" name="Z_MonoproticAcid" persistable="0" isFixedValue="0" formula="16299c03-6e50-47b9-8cd1-bb2c366ee89f" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="15f56ba9-0dd3-47bc-bbe9-58a04ad568cb" name="Z_MonoproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="16299c03-6e50-47b9-8cd1-bb2c366ee89f" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -1414,7 +1584,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="52558db1-595f-455c-ade7-12e1b7dbe2ac" name="Z_MonoproticBase" persistable="0" isFixedValue="0" formula="28dc0c08-0240-4efb-9fce-ef38f62fd76c" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="52558db1-595f-455c-ade7-12e1b7dbe2ac" name="Z_MonoproticBase" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="28dc0c08-0240-4efb-9fce-ef38f62fd76c" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -1422,7 +1594,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="139c0c41-55bf-4e78-bd37-36a2b78445b3" name="Z_MonoproticBaseDiproticAcid" persistable="0" isFixedValue="0" formula="4db5bc20-f5fc-419a-872e-de04fa1f8b0d" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="139c0c41-55bf-4e78-bd37-36a2b78445b3" name="Z_MonoproticBaseDiproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="4db5bc20-f5fc-419a-872e-de04fa1f8b0d" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -1430,7 +1604,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="2d6e32e1-61a5-4ce0-b7d5-b4fc87632282" name="Z_MonoproticBaseMonoproticAcid" persistable="0" isFixedValue="0" formula="4e18e231-930c-4403-87fb-9f6f6e151100" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="2d6e32e1-61a5-4ce0-b7d5-b4fc87632282" name="Z_MonoproticBaseMonoproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="4e18e231-930c-4403-87fb-9f6f6e151100" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -1438,7 +1614,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="9821a643-7208-49a4-99d3-596175e56a78" name="Z_Neutral" persistable="0" isFixedValue="0" formula="0f83eaa4-b154-4103-bcef-f4fcd27acde0" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="9821a643-7208-49a4-99d3-596175e56a78" name="Z_Neutral" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="0f83eaa4-b154-4103-bcef-f4fcd27acde0" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -1446,7 +1624,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="16203c0c-c743-4052-a07c-e315a7d8274f" name="Z_TriproticAcid" persistable="0" isFixedValue="0" formula="92165a31-1ec2-459b-b1dd-e32d70fdbdcf" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="16203c0c-c743-4052-a07c-e315a7d8274f" name="Z_TriproticAcid" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="92165a31-1ec2-459b-b1dd-e32d70fdbdcf" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -1454,7 +1634,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="e52af9ea-7488-4d15-bbf7-940e48ea268b" name="Z_TriproticBase" persistable="0" isFixedValue="0" formula="f95e85a9-5f79-4393-8380-d2211e46db11" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="e52af9ea-7488-4d15-bbf7-940e48ea268b" name="Z_TriproticBase" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="f95e85a9-5f79-4393-8380-d2211e46db11" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -1464,7 +1646,7 @@
           </HelpParameters>
           <FormulaCache>
             <Formulas>
-              <Formula id="ea3755a7-0e80-4ebf-bc01-f1ffaafd2af7" name="PARAM_Blood2Plasma" dim="Dimensionless" formula="(f_water_rbc + f_lipids_rbc * 10^LogP + f_proteins_rbc * KProt) * fu * HCT - HCT + 1">
+              <Formula id="ea3755a7-0e80-4ebf-bc01-f1ffaafd2af7" name="PARAM_Blood2Plasma" formula="(f_water_rbc + f_lipids_rbc * 10^LogP + f_proteins_rbc * KProt) * fu * HCT - HCT + 1">
                 <Paths>
                   <Path path="0" as="1" dim="2" />
                   <Path path="13" as="14" dim="15" />
@@ -1475,7 +1657,7 @@
                   <Path path="44" as="45" />
                 </Paths>
               </Formula>
-              <Formula id="75a33ebc-7c0e-4f8e-9b98-e7293d53e88e" name="PARAM_Ka_AP" dim="Dimensionless" formula="Max(0;Kpu_bc - (1+Z)/(1+Y)*f_iw_bc - (10^LogP*f_nl_bc + (0.3*10^LogP+0.7)*f_np_bc)/(1+Y)) * (1+Y) / AP_bc / Z">
+              <Formula id="75a33ebc-7c0e-4f8e-9b98-e7293d53e88e" name="PARAM_Ka_AP" formula="Max(0;Kpu_bc - (1+Z)/(1+Y)*f_iw_bc - (10^LogP*f_nl_bc + (0.3*10^LogP+0.7)*f_np_bc)/(1+Y)) * (1+Y) / AP_bc / Z">
                 <Paths>
                   <Path path="13" as="14" dim="15" />
                   <Path path="3" as="46" />
@@ -1488,7 +1670,7 @@
                   <Path path="55" as="56" />
                 </Paths>
               </Formula>
-              <Formula id="9bd5cadb-2949-4cc1-af4c-fcfebc8cbc20" name="PARAM_Ka_PR" dim="Dimensionless" formula="Max(0;1/fu - 1 - (10^LogP*f_nl_p + (0.3*10^LogP+0.7)*f_np_p)/(1+Y))">
+              <Formula id="9bd5cadb-2949-4cc1-af4c-fcfebc8cbc20" name="PARAM_Ka_PR" formula="Max(0;1/fu - 1 - (10^LogP*f_nl_p + (0.3*10^LogP+0.7)*f_np_p)/(1+Y))">
                 <Paths>
                   <Path path="0" as="1" dim="2" />
                   <Path path="13" as="14" dim="15" />
@@ -1498,19 +1680,19 @@
                   <Path path="59" as="60" />
                 </Paths>
               </Formula>
-              <Formula id="3fab0b0f-ae2e-4705-ad32-c1f50a72a86f" name="PARAM_LogP_ow" dim="Lipophilicity" formula="1.115 * LogP - 1.35">
+              <Formula id="3fab0b0f-ae2e-4705-ad32-c1f50a72a86f" name="PARAM_LogP_ow" dim="Log Units" formula="1.115 * LogP - 1.35">
                 <Paths>
                   <Path path="13" as="14" dim="15" />
                 </Paths>
               </Formula>
-              <Formula id="67c11811-d81b-449c-83a4-8c699bcb8359" name="PARAM_Kpu_bc" dim="Dimensionless" formula="(HCT - 1 + B2P) / fu / HCT">
+              <Formula id="67c11811-d81b-449c-83a4-8c699bcb8359" name="PARAM_Kpu_bc" formula="(HCT - 1 + B2P) / fu / HCT">
                 <Paths>
                   <Path path="61" as="62" />
                   <Path path="0" as="1" dim="2" />
                   <Path path="38" as="39" />
                 </Paths>
               </Formula>
-              <Formula id="14f1b76e-256d-440f-95cb-fcac8b48f587" name="PARAM_X" dim="Dimensionless" formula="X_Neutral + X_MonoproticBase + X_MonoproticAcid + X_DiproticBase + X_DiproticAcid + X_MonoproticBaseMonoproticAcid + X_TriproticAcid + X_TriproticBase + X_DiproticBaseMonoproticAcid + X_MonoproticBaseDiproticAcid">
+              <Formula id="14f1b76e-256d-440f-95cb-fcac8b48f587" name="PARAM_X" formula="X_Neutral + X_MonoproticBase + X_MonoproticAcid + X_DiproticBase + X_DiproticAcid + X_MonoproticBaseMonoproticAcid + X_TriproticAcid + X_TriproticBase + X_DiproticBaseMonoproticAcid + X_MonoproticBaseDiproticAcid">
                 <Paths>
                   <Path path="63" as="64" />
                   <Path path="65" as="66" />
@@ -1524,7 +1706,7 @@
                   <Path path="81" as="82" />
                 </Paths>
               </Formula>
-              <Formula id="f6f7a771-d3a9-4294-8cad-b2a441cdc1ec" name="PARAM_X_DiproticAcid" dim="Dimensionless" formula="IsDiproticAcid ? 10^(pH_IW-pKa_Acid_0) + 10^(2*pH_IW-pKa_Acid_0-pKa_Acid_1) : 0">
+              <Formula id="f6f7a771-d3a9-4294-8cad-b2a441cdc1ec" name="PARAM_X_DiproticAcid" formula="IsDiproticAcid ? 10^(pH_IW-pKa_Acid_0) + 10^(2*pH_IW-pKa_Acid_0-pKa_Acid_1) : 0">
                 <Paths>
                   <Path path="83" as="84" />
                   <Path path="85" as="86" />
@@ -1532,7 +1714,7 @@
                   <Path path="89" as="90" />
                 </Paths>
               </Formula>
-              <Formula id="ac515a71-8460-4b2a-a96f-86f250429b05" name="PARAM_X_DiproticBase" dim="Dimensionless" formula="IsDiproticBase ? 10^(pKa_Base_1-pH_IW) + 10^(pKa_Base_0+pKa_Base_1-2*pH_IW) : 0">
+              <Formula id="ac515a71-8460-4b2a-a96f-86f250429b05" name="PARAM_X_DiproticBase" formula="IsDiproticBase ? 10^(pKa_Base_1-pH_IW) + 10^(pKa_Base_0+pKa_Base_1-2*pH_IW) : 0">
                 <Paths>
                   <Path path="91" as="92" />
                   <Path path="93" as="94" />
@@ -1540,7 +1722,7 @@
                   <Path path="89" as="90" />
                 </Paths>
               </Formula>
-              <Formula id="17e9787f-79ac-450e-b962-f9330abda669" name="PARAM_X_DiproticBaseMonoproticAcid" dim="Dimensionless" formula="IsDiproticBaseMonoproticAcid ? 10^(pH_IW-pKa_Acid_0) + 10^(pKa_Base_1-pH_IW) + 10^(pKa_Base_0+pKa_Base_1-2*pH_IW) : 0">
+              <Formula id="17e9787f-79ac-450e-b962-f9330abda669" name="PARAM_X_DiproticBaseMonoproticAcid" formula="IsDiproticBaseMonoproticAcid ? 10^(pH_IW-pKa_Acid_0) + 10^(pKa_Base_1-pH_IW) + 10^(pKa_Base_0+pKa_Base_1-2*pH_IW) : 0">
                 <Paths>
                   <Path path="97" as="98" />
                   <Path path="85" as="86" />
@@ -1549,21 +1731,21 @@
                   <Path path="89" as="90" />
                 </Paths>
               </Formula>
-              <Formula id="12a1c436-fc5c-4d9c-8904-44e05298b24a" name="PARAM_X_MonoproticAcid" dim="Dimensionless" formula="IsMonoproticAcid ? 10^(pH_IW-pKa_Acid_0) : 0">
+              <Formula id="12a1c436-fc5c-4d9c-8904-44e05298b24a" name="PARAM_X_MonoproticAcid" formula="IsMonoproticAcid ? 10^(pH_IW-pKa_Acid_0) : 0">
                 <Paths>
                   <Path path="99" as="100" />
                   <Path path="85" as="86" />
                   <Path path="89" as="90" />
                 </Paths>
               </Formula>
-              <Formula id="d568d014-5313-4416-aa98-4290b263d548" name="PARAM_X_MonoproticBase" dim="Dimensionless" formula="IsMonoproticBase ? 10^(pKa_Base_0-pH_IW) : 0">
+              <Formula id="d568d014-5313-4416-aa98-4290b263d548" name="PARAM_X_MonoproticBase" formula="IsMonoproticBase ? 10^(pKa_Base_0-pH_IW) : 0">
                 <Paths>
                   <Path path="101" as="102" />
                   <Path path="93" as="94" />
                   <Path path="89" as="90" />
                 </Paths>
               </Formula>
-              <Formula id="24248a10-001a-4357-a618-0538332389c8" name="PARAM_X_MonoproticBaseDiproticAcid" dim="Dimensionless" formula="IsMonoproticBaseDiproticAcid ? 10^(pKa_Base_0-pH_IW) + 10^(pH_IW-pKa_Acid_0) + 10^(2*pH_IW-pKa_Acid_0-pKa_Acid_1) : 0">
+              <Formula id="24248a10-001a-4357-a618-0538332389c8" name="PARAM_X_MonoproticBaseDiproticAcid" formula="IsMonoproticBaseDiproticAcid ? 10^(pKa_Base_0-pH_IW) + 10^(pH_IW-pKa_Acid_0) + 10^(2*pH_IW-pKa_Acid_0-pKa_Acid_1) : 0">
                 <Paths>
                   <Path path="103" as="104" />
                   <Path path="85" as="86" />
@@ -1572,7 +1754,7 @@
                   <Path path="89" as="90" />
                 </Paths>
               </Formula>
-              <Formula id="ab0844ac-799c-464c-896e-e8c23d60b2f4" name="PARAM_X_MonoproticBaseMonoproticAcid" dim="Dimensionless" formula="IsMonoproticBaseMonoproticAcid ? 10^(pKa_Base_0-pH_IW) + 10^(pH_IW-pKa_Acid_0) : 0">
+              <Formula id="ab0844ac-799c-464c-896e-e8c23d60b2f4" name="PARAM_X_MonoproticBaseMonoproticAcid" formula="IsMonoproticBaseMonoproticAcid ? 10^(pKa_Base_0-pH_IW) + 10^(pH_IW-pKa_Acid_0) : 0">
                 <Paths>
                   <Path path="105" as="106" />
                   <Path path="85" as="86" />
@@ -1580,7 +1762,7 @@
                   <Path path="89" as="90" />
                 </Paths>
               </Formula>
-              <Formula id="da6f6c06-c7f1-4d4b-8df6-c5288af3e738" name="PARAM_X_TriproticAcid" dim="Dimensionless" formula="IsTriproticAcid ? 10^(pH_IW-pKa_Acid_0) + 10^(2*pH_IW-pKa_Acid_0-pKa_Acid_1) + 10^(3*pH_IW-pKa_Acid_0-pKa_Acid_1-pKa_Acid_2) : 0">
+              <Formula id="da6f6c06-c7f1-4d4b-8df6-c5288af3e738" name="PARAM_X_TriproticAcid" formula="IsTriproticAcid ? 10^(pH_IW-pKa_Acid_0) + 10^(2*pH_IW-pKa_Acid_0-pKa_Acid_1) + 10^(3*pH_IW-pKa_Acid_0-pKa_Acid_1-pKa_Acid_2) : 0">
                 <Paths>
                   <Path path="107" as="108" />
                   <Path path="85" as="86" />
@@ -1589,7 +1771,7 @@
                   <Path path="89" as="90" />
                 </Paths>
               </Formula>
-              <Formula id="7497efa7-8e56-4da3-843d-d5ba678c07af" name="PARAM_X_TriproticBase" dim="Dimensionless" formula="IsTriproticBase ? 10^(pKa_Base_2-pH_IW) + 10^(pKa_Base_2+pKa_Base_1-2*pH_IW) + 10^(pKa_Base_0+pKa_Base_1+pKa_Base_2-3*pH_IW) : 0">
+              <Formula id="7497efa7-8e56-4da3-843d-d5ba678c07af" name="PARAM_X_TriproticBase" formula="IsTriproticBase ? 10^(pKa_Base_2-pH_IW) + 10^(pKa_Base_2+pKa_Base_1-2*pH_IW) + 10^(pKa_Base_0+pKa_Base_1+pKa_Base_2-3*pH_IW) : 0">
                 <Paths>
                   <Path path="111" as="112" />
                   <Path path="93" as="94" />
@@ -1598,7 +1780,7 @@
                   <Path path="89" as="90" />
                 </Paths>
               </Formula>
-              <Formula id="185aeac6-bf38-404e-8c68-14cb13d3b5f7" name="PARAM_Y" dim="Dimensionless" formula="Y_Neutral + Y_MonoproticBase + Y_MonoproticAcid + Y_DiproticBase + Y_DiproticAcid + Y_MonoproticBaseMonoproticAcid + Y_TriproticAcid + Y_TriproticBase + Y_DiproticBaseMonoproticAcid + Y_MonoproticBaseDiproticAcid">
+              <Formula id="185aeac6-bf38-404e-8c68-14cb13d3b5f7" name="PARAM_Y" formula="Y_Neutral + Y_MonoproticBase + Y_MonoproticAcid + Y_DiproticBase + Y_DiproticAcid + Y_MonoproticBaseMonoproticAcid + Y_TriproticAcid + Y_TriproticBase + Y_DiproticBaseMonoproticAcid + Y_MonoproticBaseDiproticAcid">
                 <Paths>
                   <Path path="115" as="116" />
                   <Path path="117" as="118" />
@@ -1612,7 +1794,7 @@
                   <Path path="133" as="134" />
                 </Paths>
               </Formula>
-              <Formula id="0f1cb615-8f1c-41b7-9fa4-21820f00a920" name="PARAM_Y_DiproticAcid" dim="Dimensionless" formula="IsDiproticAcid ? 10^(pH_PLS-pKa_Acid_0) + 10^(2*pH_PLS-pKa_Acid_0-pKa_Acid_1) : 0">
+              <Formula id="0f1cb615-8f1c-41b7-9fa4-21820f00a920" name="PARAM_Y_DiproticAcid" formula="IsDiproticAcid ? 10^(pH_PLS-pKa_Acid_0) + 10^(2*pH_PLS-pKa_Acid_0-pKa_Acid_1) : 0">
                 <Paths>
                   <Path path="83" as="84" />
                   <Path path="85" as="86" />
@@ -1620,7 +1802,7 @@
                   <Path path="135" as="136" />
                 </Paths>
               </Formula>
-              <Formula id="c0b5bf89-46d7-4a37-a2a7-06a537d8e2a0" name="PARAM_Y_DiproticBase" dim="Dimensionless" formula="IsDiproticBase ? 10^(pKa_Base_1-pH_PLS) + 10^(pKa_Base_0+pKa_Base_1-2*pH_PLS) : 0">
+              <Formula id="c0b5bf89-46d7-4a37-a2a7-06a537d8e2a0" name="PARAM_Y_DiproticBase" formula="IsDiproticBase ? 10^(pKa_Base_1-pH_PLS) + 10^(pKa_Base_0+pKa_Base_1-2*pH_PLS) : 0">
                 <Paths>
                   <Path path="91" as="92" />
                   <Path path="93" as="94" />
@@ -1628,7 +1810,7 @@
                   <Path path="135" as="136" />
                 </Paths>
               </Formula>
-              <Formula id="b09b93e2-604f-4b17-bcaf-b8f1df487a1d" name="PARAM_Y_DiproticBaseMonoproticAcid" dim="Dimensionless" formula="IsDiproticBaseMonoproticAcid ? 10^(pH_PLS-pKa_Acid_0) + 10^(pKa_Base_1-pH_PLS) + 10^(pKa_Base_0+pKa_Base_1-2*pH_PLS) : 0">
+              <Formula id="b09b93e2-604f-4b17-bcaf-b8f1df487a1d" name="PARAM_Y_DiproticBaseMonoproticAcid" formula="IsDiproticBaseMonoproticAcid ? 10^(pH_PLS-pKa_Acid_0) + 10^(pKa_Base_1-pH_PLS) + 10^(pKa_Base_0+pKa_Base_1-2*pH_PLS) : 0">
                 <Paths>
                   <Path path="97" as="98" />
                   <Path path="85" as="86" />
@@ -1637,21 +1819,21 @@
                   <Path path="135" as="136" />
                 </Paths>
               </Formula>
-              <Formula id="8eb1e423-aae0-4592-94a1-92e34f618187" name="PARAM_Y_MonoproticAcid" dim="Dimensionless" formula="IsMonoproticAcid ? 10^(pH_PLS-pKa_Acid_0) : 0">
+              <Formula id="8eb1e423-aae0-4592-94a1-92e34f618187" name="PARAM_Y_MonoproticAcid" formula="IsMonoproticAcid ? 10^(pH_PLS-pKa_Acid_0) : 0">
                 <Paths>
                   <Path path="99" as="100" />
                   <Path path="85" as="86" />
                   <Path path="135" as="136" />
                 </Paths>
               </Formula>
-              <Formula id="1dbc8692-7e74-4fee-8396-69e969b0f7e0" name="PARAM_Y_MonoproticBase" dim="Dimensionless" formula="IsMonoproticBase ? 10^(pKa_Base_0-pH_PLS) : 0">
+              <Formula id="1dbc8692-7e74-4fee-8396-69e969b0f7e0" name="PARAM_Y_MonoproticBase" formula="IsMonoproticBase ? 10^(pKa_Base_0-pH_PLS) : 0">
                 <Paths>
                   <Path path="101" as="102" />
                   <Path path="93" as="94" />
                   <Path path="135" as="136" />
                 </Paths>
               </Formula>
-              <Formula id="8a1a1950-f021-4acc-bac7-bee2e3b26816" name="PARAM_Y_MonoproticBaseDiproticAcid" dim="Dimensionless" formula="IsMonoproticBaseDiproticAcid ? 10^(pKa_Base_0-pH_PLS) + 10^(pH_PLS-pKa_Acid_0) + 10^(2*pH_PLS-pKa_Acid_0-pKa_Acid_1) : 0">
+              <Formula id="8a1a1950-f021-4acc-bac7-bee2e3b26816" name="PARAM_Y_MonoproticBaseDiproticAcid" formula="IsMonoproticBaseDiproticAcid ? 10^(pKa_Base_0-pH_PLS) + 10^(pH_PLS-pKa_Acid_0) + 10^(2*pH_PLS-pKa_Acid_0-pKa_Acid_1) : 0">
                 <Paths>
                   <Path path="103" as="104" />
                   <Path path="85" as="86" />
@@ -1660,7 +1842,7 @@
                   <Path path="135" as="136" />
                 </Paths>
               </Formula>
-              <Formula id="3cbd4ff1-0b71-4c5a-802b-44733a2c38eb" name="PARAM_Y_MonoproticBaseMonoproticAcid" dim="Dimensionless" formula="IsMonoproticBaseMonoproticAcid ? 10^(pKa_Base_0-pH_PLS) + 10^(pH_PLS-pKa_Acid_0) : 0">
+              <Formula id="3cbd4ff1-0b71-4c5a-802b-44733a2c38eb" name="PARAM_Y_MonoproticBaseMonoproticAcid" formula="IsMonoproticBaseMonoproticAcid ? 10^(pKa_Base_0-pH_PLS) + 10^(pH_PLS-pKa_Acid_0) : 0">
                 <Paths>
                   <Path path="105" as="106" />
                   <Path path="85" as="86" />
@@ -1668,7 +1850,7 @@
                   <Path path="135" as="136" />
                 </Paths>
               </Formula>
-              <Formula id="030aa1e0-9af5-4e91-b9dc-83c11e9109e6" name="PARAM_Y_TriproticAcid" dim="Dimensionless" formula="IsTriproticAcid ? 10^(pH_PLS-pKa_Acid_0) + 10^(2*pH_PLS-pKa_Acid_0-pKa_Acid_1) + 10^(3*pH_PLS-pKa_Acid_0-pKa_Acid_1-pKa_Acid_2) : 0">
+              <Formula id="030aa1e0-9af5-4e91-b9dc-83c11e9109e6" name="PARAM_Y_TriproticAcid" formula="IsTriproticAcid ? 10^(pH_PLS-pKa_Acid_0) + 10^(2*pH_PLS-pKa_Acid_0-pKa_Acid_1) + 10^(3*pH_PLS-pKa_Acid_0-pKa_Acid_1-pKa_Acid_2) : 0">
                 <Paths>
                   <Path path="107" as="108" />
                   <Path path="85" as="86" />
@@ -1677,7 +1859,7 @@
                   <Path path="135" as="136" />
                 </Paths>
               </Formula>
-              <Formula id="b71de829-5582-46f4-b66a-9f9e857eed32" name="PARAM_Y_TriproticBase" dim="Dimensionless" formula="IsTriproticBase ? 10^(pKa_Base_2-pH_PLS) + 10^(pKa_Base_2+pKa_Base_1-2*pH_PLS) + 10^(pKa_Base_0+pKa_Base_1+pKa_Base_2-3*pH_PLS) : 0">
+              <Formula id="b71de829-5582-46f4-b66a-9f9e857eed32" name="PARAM_Y_TriproticBase" formula="IsTriproticBase ? 10^(pKa_Base_2-pH_PLS) + 10^(pKa_Base_2+pKa_Base_1-2*pH_PLS) + 10^(pKa_Base_0+pKa_Base_1+pKa_Base_2-3*pH_PLS) : 0">
                 <Paths>
                   <Path path="111" as="112" />
                   <Path path="93" as="94" />
@@ -1686,7 +1868,7 @@
                   <Path path="135" as="136" />
                 </Paths>
               </Formula>
-              <Formula id="0646e30d-a096-4d95-92ed-6d30fa89ced7" name="PARAM_Z" dim="Dimensionless" formula="Z_Neutral + Z_MonoproticBase + Z_MonoproticAcid + Z_DiproticBase + Z_DiproticAcid + Z_MonoproticBaseMonoproticAcid + Z_TriproticAcid + Z_TriproticBase + Z_DiproticBaseMonoproticAcid + Z_MonoproticBaseDiproticAcid">
+              <Formula id="0646e30d-a096-4d95-92ed-6d30fa89ced7" name="PARAM_Z" formula="Z_Neutral + Z_MonoproticBase + Z_MonoproticAcid + Z_DiproticBase + Z_DiproticAcid + Z_MonoproticBaseMonoproticAcid + Z_TriproticAcid + Z_TriproticBase + Z_DiproticBaseMonoproticAcid + Z_MonoproticBaseDiproticAcid">
                 <Paths>
                   <Path path="137" as="138" />
                   <Path path="139" as="140" />
@@ -1700,12 +1882,12 @@
                   <Path path="155" as="156" />
                 </Paths>
               </Formula>
-              <Formula id="a65a9097-1d4f-487e-9947-36c3e8c89292" name="PARAM_Z_DiproticAcid" dim="Dimensionless" formula="IsDiproticAcid ? 1 : 0">
+              <Formula id="a65a9097-1d4f-487e-9947-36c3e8c89292" name="PARAM_Z_DiproticAcid" formula="IsDiproticAcid ? 1 : 0">
                 <Paths>
                   <Path path="83" as="84" />
                 </Paths>
               </Formula>
-              <Formula id="ee412cc3-bdca-440c-886a-007a1a2b2ba9" name="PARAM_Z_DiproticBase" dim="Dimensionless" formula="IsDiproticBase ? 10^(pKa_Base_1-pH_RBC) + 10^(pKa_Base_0+pKa_Base_1-2*pH_RBC) : 0">
+              <Formula id="ee412cc3-bdca-440c-886a-007a1a2b2ba9" name="PARAM_Z_DiproticBase" formula="IsDiproticBase ? 10^(pKa_Base_1-pH_RBC) + 10^(pKa_Base_0+pKa_Base_1-2*pH_RBC) : 0">
                 <Paths>
                   <Path path="91" as="92" />
                   <Path path="93" as="94" />
@@ -1713,7 +1895,7 @@
                   <Path path="157" as="158" />
                 </Paths>
               </Formula>
-              <Formula id="bb0a981c-ddad-4109-afbb-3f04273b0c48" name="PARAM_Z_DiproticBaseMonoproticAcid" dim="Dimensionless" formula="IsDiproticBaseMonoproticAcid ? 10^(pH_RBC-pKa_Acid_0) + 10^(pKa_Base_1-pH_RBC) + 10^(pKa_Base_0+pKa_Base_1-2*pH_RBC) : 0">
+              <Formula id="bb0a981c-ddad-4109-afbb-3f04273b0c48" name="PARAM_Z_DiproticBaseMonoproticAcid" formula="IsDiproticBaseMonoproticAcid ? 10^(pH_RBC-pKa_Acid_0) + 10^(pKa_Base_1-pH_RBC) + 10^(pKa_Base_0+pKa_Base_1-2*pH_RBC) : 0">
                 <Paths>
                   <Path path="97" as="98" />
                   <Path path="85" as="86" />
@@ -1722,19 +1904,19 @@
                   <Path path="157" as="158" />
                 </Paths>
               </Formula>
-              <Formula id="16299c03-6e50-47b9-8cd1-bb2c366ee89f" name="PARAM_Z_MonoproticAcid" dim="Dimensionless" formula="IsMonoproticAcid ? 1 : 0">
+              <Formula id="16299c03-6e50-47b9-8cd1-bb2c366ee89f" name="PARAM_Z_MonoproticAcid" formula="IsMonoproticAcid ? 1 : 0">
                 <Paths>
                   <Path path="99" as="100" />
                 </Paths>
               </Formula>
-              <Formula id="28dc0c08-0240-4efb-9fce-ef38f62fd76c" name="PARAM_Z_MonoproticBase" dim="Dimensionless" formula="IsMonoproticBase ? 10^(pKa_Base_0-pH_RBC) : 0">
+              <Formula id="28dc0c08-0240-4efb-9fce-ef38f62fd76c" name="PARAM_Z_MonoproticBase" formula="IsMonoproticBase ? 10^(pKa_Base_0-pH_RBC) : 0">
                 <Paths>
                   <Path path="101" as="102" />
                   <Path path="93" as="94" />
                   <Path path="157" as="158" />
                 </Paths>
               </Formula>
-              <Formula id="4db5bc20-f5fc-419a-872e-de04fa1f8b0d" name="PARAM_Z_MonoproticBaseDiproticAcid" dim="Dimensionless" formula="IsMonoproticBaseDiproticAcid ? 10^(pKa_Base_0-pH_RBC) + 10^(pH_RBC-pKa_Acid_0) + 10^(2*pH_RBC-pKa_Acid_0-pKa_Acid_1) : 0">
+              <Formula id="4db5bc20-f5fc-419a-872e-de04fa1f8b0d" name="PARAM_Z_MonoproticBaseDiproticAcid" formula="IsMonoproticBaseDiproticAcid ? 10^(pKa_Base_0-pH_RBC) + 10^(pH_RBC-pKa_Acid_0) + 10^(2*pH_RBC-pKa_Acid_0-pKa_Acid_1) : 0">
                 <Paths>
                   <Path path="103" as="104" />
                   <Path path="85" as="86" />
@@ -1743,7 +1925,7 @@
                   <Path path="157" as="158" />
                 </Paths>
               </Formula>
-              <Formula id="4e18e231-930c-4403-87fb-9f6f6e151100" name="PARAM_Z_MonoproticBaseMonoproticAcid" dim="Dimensionless" formula="IsMonoproticBaseMonoproticAcid ? 10^(pKa_Base_0-pH_RBC) + 10^(pH_RBC-pKa_Acid_0) : 0">
+              <Formula id="4e18e231-930c-4403-87fb-9f6f6e151100" name="PARAM_Z_MonoproticBaseMonoproticAcid" formula="IsMonoproticBaseMonoproticAcid ? 10^(pKa_Base_0-pH_RBC) + 10^(pH_RBC-pKa_Acid_0) : 0">
                 <Paths>
                   <Path path="105" as="106" />
                   <Path path="85" as="86" />
@@ -1751,17 +1933,17 @@
                   <Path path="157" as="158" />
                 </Paths>
               </Formula>
-              <Formula id="0f83eaa4-b154-4103-bcef-f4fcd27acde0" name="PARAM_Z_Neutral" dim="Dimensionless" formula="IsNeutral ? 1 : 0">
+              <Formula id="0f83eaa4-b154-4103-bcef-f4fcd27acde0" name="PARAM_Z_Neutral" formula="IsNeutral ? 1 : 0">
                 <Paths>
                   <Path path="159" as="6" />
                 </Paths>
               </Formula>
-              <Formula id="92165a31-1ec2-459b-b1dd-e32d70fdbdcf" name="PARAM_Z_TriproticAcid" dim="Dimensionless" formula="IsTriproticAcid ? 1 : 0">
+              <Formula id="92165a31-1ec2-459b-b1dd-e32d70fdbdcf" name="PARAM_Z_TriproticAcid" formula="IsTriproticAcid ? 1 : 0">
                 <Paths>
                   <Path path="107" as="108" />
                 </Paths>
               </Formula>
-              <Formula id="f95e85a9-5f79-4393-8380-d2211e46db11" name="PARAM_Z_TriproticBase" dim="Dimensionless" formula="IsTriproticBase ? 10^(pKa_Base_2-pH_RBC) + 10^(pKa_Base_2+pKa_Base_1-2*pH_RBC) + 10^(pKa_Base_0+pKa_Base_1+pKa_Base_2-3*pH_RBC) : 0">
+              <Formula id="f95e85a9-5f79-4393-8380-d2211e46db11" name="PARAM_Z_TriproticBase" formula="IsTriproticBase ? 10^(pKa_Base_2-pH_RBC) + 10^(pKa_Base_2+pKa_Base_1-2*pH_RBC) + 10^(pKa_Base_0+pKa_Base_1+pKa_Base_2-3*pH_RBC) : 0">
                 <Paths>
                   <Path path="111" as="112" />
                   <Path path="93" as="94" />
@@ -1770,8 +1952,6 @@
                   <Path path="157" as="158" />
                 </Paths>
               </Formula>
-              <ConstantFormula id="d86fa8be-a533-4c8e-bfb6-01453d6162e6" dim="Dimensionless" value="0" />
-              <ConstantFormula id="707899c5-e41a-4d7e-b7f7-cd9dad3b8628" dim="Dimensionless" value="0" />
             </Formulas>
             <StringMap>
               <Map s="MOLECULE|Fraction unbound (plasma)" id="0" />
@@ -1789,7 +1969,7 @@
               <Map s="Ka_PR" id="12" />
               <Map s="MOLECULE|Lipophilicity" id="13" />
               <Map s="LogP" id="14" />
-              <Map s="Lipophilicity" id="15" />
+              <Map s="Log Units" id="15" />
               <Map s="MOLECULE|X" id="16" />
               <Map s="X" id="17" />
               <Map s="MOLECULE|Y" id="18" />
@@ -1937,10 +2117,11 @@
             </StringMap>
           </FormulaCache>
         </CoreCalculationMethod>
-        <CoreCalculationMethod id="265a0b4d-e769-490d-9184-5043efd1d562" name="Cellular partition coefficient method - Schmitt" category="DistributionCellular">
+        <CoreCalculationMethod id="265a0b4d-e769-490d-9184-5043efd1d562" name="Cellular partition coefficient method - Schmitt" icon="CoreCalculationMethod" bbVersion="0" category="DistributionCellular">
+          <Creation createdAt="5248846133421202645" createdBy="Michael" creationMode="New" origin="Other" />
           <OutputFormulas>
             <KeyValue>
-              <Formula id="ca02ae77-7ed0-476a-8d5c-3449661edee1" name="PARAM_K_rbc" dim="Dimensionless" formula="(f_w + K_n_L * f_nl + K_n_PL * f_np + K_a_PL * AP_BC + KProt * f_proteins) * fu">
+              <Formula id="ca02ae77-7ed0-476a-8d5c-3449661edee1" name="PARAM_K_rbc" formula="(f_w + K_n_L * f_nl + K_n_PL * f_np + K_a_PL * AP_BC + KProt * f_proteins) * fu">
                 <Paths>
                   <Path path="0" as="1" dim="2" />
                   <Path path="3" as="4" dim="5" />
@@ -1964,7 +2145,7 @@
               </ParameterDescriptor>
             </KeyValue>
             <KeyValue>
-              <Formula id="b6d2e188-ce15-4cc6-a788-a570cd141869" name="PARAM_K_cell_pls_Schmitt" dim="Dimensionless" formula="(f_w + K_n_L * f_nl + K_n_PL * f_np + K_a_PL * AP_T + KProt * f_proteins) * fu">
+              <Formula id="b6d2e188-ce15-4cc6-a788-a570cd141869" name="PARAM_K_cell_pls_Schmitt" formula="(f_w + K_n_L * f_nl + K_n_PL * f_np + K_a_PL * AP_T + KProt * f_proteins) * fu">
                 <Paths>
                   <Path path="24" as="7" />
                   <Path path="25" as="9" />
@@ -1991,7 +2172,9 @@
           </OutputFormulas>
           <HelpParameters>
             <KeyValue>
-              <Parameter id="e25d8933-0acd-4d06-bff6-165ac926a66d" name="K_a_PL_pH_Factor" persistable="0" isFixedValue="0" formula="4151f90d-cbe1-409d-8498-885496894183" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="e25d8933-0acd-4d06-bff6-165ac926a66d" name="K_a_PL_pH_Factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="4151f90d-cbe1-409d-8498-885496894183" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -1999,7 +2182,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="b4746919-78db-485d-8bbc-89827431499c" name="logD at pH (blood cells)" persistable="0" isFixedValue="0" formula="bd5b2b66-0b2e-47cc-80f2-feeeab38c854" dim="Lipophilicity" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="b4746919-78db-485d-8bbc-89827431499c" name="logD at pH (blood cells)" icon="Parameter" persistable="0" isFixedValue="0" dim="Log Units" quantityType="Parameter" negativeValuesAllowed="1" formula="bd5b2b66-0b2e-47cc-80f2-feeeab38c854" isDefault="0" displayUnit="Log Units">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -2007,7 +2192,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="1dd7f035-87a9-4d6b-a51e-bfeec4467717" name="logD factor" persistable="0" isFixedValue="0" formula="2cec3255-3dea-4534-95a6-ef59a7f0cff3" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="1dd7f035-87a9-4d6b-a51e-bfeec4467717" name="logD factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="2cec3255-3dea-4534-95a6-ef59a7f0cff3" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -2015,7 +2202,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="f54e5f68-6423-477b-8ecb-eba85d19eb44" name="Partition coefficient (acidic phospholipids/blood cells water)" persistable="0" isFixedValue="0" formula="775cb5af-d8eb-420a-bfc9-e16550f3b7a1" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="f54e5f68-6423-477b-8ecb-eba85d19eb44" name="Partition coefficient (acidic phospholipids/blood cells water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="775cb5af-d8eb-420a-bfc9-e16550f3b7a1" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -2023,7 +2212,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="0fabb689-1b3c-405b-8b10-6e604f11bbf8" name="Partition coefficient (neutral lipids/blood cells water)" persistable="0" isFixedValue="0" formula="b8669309-c29f-4117-ab83-9f8ea4bc1cdc" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="0fabb689-1b3c-405b-8b10-6e604f11bbf8" name="Partition coefficient (neutral lipids/blood cells water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="b8669309-c29f-4117-ab83-9f8ea4bc1cdc" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -2031,7 +2222,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="76e4da55-99f4-4c36-a83c-0b66bc1f9fed" name="Partition coefficient (neutral phospholipids/blood cells water)" persistable="0" isFixedValue="0" formula="8fb455a9-36c0-466c-8ce7-49c487e18094" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="76e4da55-99f4-4c36-a83c-0b66bc1f9fed" name="Partition coefficient (neutral phospholipids/blood cells water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="8fb455a9-36c0-466c-8ce7-49c487e18094" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -2039,7 +2232,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="395a84e5-1d67-48a9-9dcf-69932f762c5e" name="pKa_pH_WS_bc_F1" persistable="0" isFixedValue="0" formula="4b138d67-c6cf-47da-9f90-45b580ed280f" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="395a84e5-1d67-48a9-9dcf-69932f762c5e" name="pKa_pH_WS_bc_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="4b138d67-c6cf-47da-9f90-45b580ed280f" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -2047,7 +2242,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="d1c90688-4660-4633-aae7-7f397e4d24f3" name="pKa_pH_WS_bc_F2" persistable="0" isFixedValue="0" formula="a5dd4192-1864-45a8-9b8e-141730dc47ee" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="d1c90688-4660-4633-aae7-7f397e4d24f3" name="pKa_pH_WS_bc_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="a5dd4192-1864-45a8-9b8e-141730dc47ee" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -2055,7 +2252,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="3f2ddd15-ad66-4b94-b5e7-e1b95b31044f" name="pKa_pH_WS_bc_F3" persistable="0" isFixedValue="0" formula="58957524-4efe-46c8-9d1c-942c92f4c78f" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="3f2ddd15-ad66-4b94-b5e7-e1b95b31044f" name="pKa_pH_WS_bc_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="58957524-4efe-46c8-9d1c-942c92f4c78f" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -2063,7 +2262,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="af0a369d-a737-4577-bcef-e1d569afd97f" name="pKa_pH_WS_bc_K1" persistable="0" isFixedValue="0" formula="dcc40109-23cf-4adf-ae32-a4bce31bd74d" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="af0a369d-a737-4577-bcef-e1d569afd97f" name="pKa_pH_WS_bc_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="dcc40109-23cf-4adf-ae32-a4bce31bd74d" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -2071,7 +2272,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="84a58fe1-2916-4fd0-a9db-3563a435ad38" name="pKa_pH_WS_bc_K2" persistable="0" isFixedValue="0" formula="ee948a34-6a9c-4e4f-9748-c5a421e8ea9e" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="84a58fe1-2916-4fd0-a9db-3563a435ad38" name="pKa_pH_WS_bc_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ee948a34-6a9c-4e4f-9748-c5a421e8ea9e" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -2079,7 +2282,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="6535e475-a361-4df1-a1f2-ef4632d5e14b" name="pKa_pH_WS_bc_K3" persistable="0" isFixedValue="0" formula="204b0782-551d-4ad1-889e-5078a4b0f0e7" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="6535e475-a361-4df1-a1f2-ef4632d5e14b" name="pKa_pH_WS_bc_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="204b0782-551d-4ad1-889e-5078a4b0f0e7" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -2087,7 +2292,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="3736c57d-5dfa-4593-971c-0acbfd172786" name="pKa_pH_WS_bc_K4" persistable="0" isFixedValue="0" formula="29dd0e1d-0a11-4eb1-b452-57489851a6ad" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="3736c57d-5dfa-4593-971c-0acbfd172786" name="pKa_pH_WS_bc_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="29dd0e1d-0a11-4eb1-b452-57489851a6ad" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -2095,7 +2302,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="782f7548-6ee0-4049-950e-698a44fe1282" name="pKa_pH_WS_bc_K5" persistable="0" isFixedValue="0" formula="95db8b71-9f49-4856-9309-a1d2db666ede" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="782f7548-6ee0-4049-950e-698a44fe1282" name="pKa_pH_WS_bc_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="95db8b71-9f49-4856-9309-a1d2db666ede" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -2103,7 +2312,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="1c8054f7-7916-44bf-9694-cb410326c9f9" name="pKa_pH_WS_bc_K6" persistable="0" isFixedValue="0" formula="97d91e32-1c0a-474f-9a27-d89d76070410" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="1c8054f7-7916-44bf-9694-cb410326c9f9" name="pKa_pH_WS_bc_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="97d91e32-1c0a-474f-9a27-d89d76070410" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -2111,7 +2322,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="716cd2e7-26f9-464b-97eb-9769a4b9b83c" name="pKa_pH_WS_bc_K7" persistable="0" isFixedValue="0" formula="84538ce4-691f-4885-b026-1d4c8af7cf56" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="716cd2e7-26f9-464b-97eb-9769a4b9b83c" name="pKa_pH_WS_bc_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="84538ce4-691f-4885-b026-1d4c8af7cf56" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -2119,7 +2332,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="905808ba-8690-4bba-b644-f3f760f2dc33" name="pKa_pH_WS_bc_K8" persistable="0" isFixedValue="0" formula="104dbb7c-4a1c-47dc-9422-3f2c69c2c582" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="905808ba-8690-4bba-b644-f3f760f2dc33" name="pKa_pH_WS_bc_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="104dbb7c-4a1c-47dc-9422-3f2c69c2c582" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -2127,7 +2342,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="b9f9fa5c-bc02-4307-85b9-87c3ae407038" name="K_a_PL_pH_Factor" persistable="0" isFixedValue="0" formula="f1000e3e-620d-46de-b898-153d8e77a001" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="b9f9fa5c-bc02-4307-85b9-87c3ae407038" name="K_a_PL_pH_Factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="f1000e3e-620d-46de-b898-153d8e77a001" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="Neighborhood: Interstitial / Intracellular" />
@@ -2135,7 +2352,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="7e8d49ff-d90c-47ad-9b65-68c435336bbe" name="logD at pH (intracellular)" persistable="0" isFixedValue="0" formula="d4220058-900d-4978-8bfc-0713dfa5fea2" dim="Lipophilicity" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="7e8d49ff-d90c-47ad-9b65-68c435336bbe" name="logD at pH (intracellular)" icon="Parameter" persistable="0" isFixedValue="0" dim="Log Units" quantityType="Parameter" negativeValuesAllowed="1" formula="d4220058-900d-4978-8bfc-0713dfa5fea2" isDefault="0" displayUnit="Log Units">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="Neighborhood: Interstitial / Intracellular" />
@@ -2143,7 +2362,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="4688cf80-1155-4a2f-be4e-33ad082789fd" name="logD factor" persistable="0" isFixedValue="0" formula="32ba85ae-ecd4-410b-ad18-abcb1378a594" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="4688cf80-1155-4a2f-be4e-33ad082789fd" name="logD factor" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="32ba85ae-ecd4-410b-ad18-abcb1378a594" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="Neighborhood: Interstitial / Intracellular" />
@@ -2151,7 +2372,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="b83f5c0d-2c76-409f-9620-d9260e7c24d0" name="Partition coefficient (acidic phospholipids/intracellular water)" persistable="0" isFixedValue="0" formula="b4c1695c-1b12-46e5-9d2a-17f135600475" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="b83f5c0d-2c76-409f-9620-d9260e7c24d0" name="Partition coefficient (acidic phospholipids/intracellular water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="b4c1695c-1b12-46e5-9d2a-17f135600475" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="Neighborhood: Interstitial / Intracellular" />
@@ -2159,7 +2382,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="f14f1a97-9877-4b3e-8e43-0c752106f982" name="Partition coefficient (neutral lipids/intracellular water)" persistable="0" isFixedValue="0" formula="0a36f8b8-59f9-4cdb-a6eb-58687d717745" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="f14f1a97-9877-4b3e-8e43-0c752106f982" name="Partition coefficient (neutral lipids/intracellular water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="0a36f8b8-59f9-4cdb-a6eb-58687d717745" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="Neighborhood: Interstitial / Intracellular" />
@@ -2167,7 +2392,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="f5048145-161d-48d0-b0e6-54d73be1f54b" name="Partition coefficient (neutral phospholipids/intracellular water)" persistable="0" isFixedValue="0" formula="461057fe-8457-4ac1-b9f7-140995b33f47" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="f5048145-161d-48d0-b0e6-54d73be1f54b" name="Partition coefficient (neutral phospholipids/intracellular water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="461057fe-8457-4ac1-b9f7-140995b33f47" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="Neighborhood: Interstitial / Intracellular" />
@@ -2175,7 +2402,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="d14c7390-8807-46c9-a7a7-7f7dc13d97b0" name="pKa_pH_WS_cell_F1" persistable="0" isFixedValue="0" formula="a69306a7-873d-4fb6-9d68-49b049f9d30a" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="d14c7390-8807-46c9-a7a7-7f7dc13d97b0" name="pKa_pH_WS_cell_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="a69306a7-873d-4fb6-9d68-49b049f9d30a" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="Neighborhood: Interstitial / Intracellular" />
@@ -2183,7 +2412,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="2ea01f13-4f7a-4707-bf32-dde0c2c6d650" name="pKa_pH_WS_cell_F2" persistable="0" isFixedValue="0" formula="0365195c-5424-466a-894c-dd617bc08036" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="2ea01f13-4f7a-4707-bf32-dde0c2c6d650" name="pKa_pH_WS_cell_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="0365195c-5424-466a-894c-dd617bc08036" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="Neighborhood: Interstitial / Intracellular" />
@@ -2191,7 +2422,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="d4a052ea-581c-411b-86e7-73bf280cb096" name="pKa_pH_WS_cell_F3" persistable="0" isFixedValue="0" formula="5cf2da6b-5608-49ad-828f-9c15e2564c66" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="d4a052ea-581c-411b-86e7-73bf280cb096" name="pKa_pH_WS_cell_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="5cf2da6b-5608-49ad-828f-9c15e2564c66" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="Neighborhood: Interstitial / Intracellular" />
@@ -2199,7 +2432,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="050ecc9c-e79a-4718-a661-46f73647fc2e" name="pKa_pH_WS_cell_K1" persistable="0" isFixedValue="0" formula="ec7661e7-87c7-47da-9782-01b5a6a356a2" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="050ecc9c-e79a-4718-a661-46f73647fc2e" name="pKa_pH_WS_cell_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ec7661e7-87c7-47da-9782-01b5a6a356a2" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="Neighborhood: Interstitial / Intracellular" />
@@ -2207,7 +2442,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="754318e2-b48d-4ec0-9647-95ebb96f250f" name="pKa_pH_WS_cell_K2" persistable="0" isFixedValue="0" formula="65ba7f80-ef94-46ed-a707-da86eeacd4d4" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="754318e2-b48d-4ec0-9647-95ebb96f250f" name="pKa_pH_WS_cell_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="65ba7f80-ef94-46ed-a707-da86eeacd4d4" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="Neighborhood: Interstitial / Intracellular" />
@@ -2215,7 +2452,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="ca08ee50-73a5-4834-ae8e-2f1d9468ef26" name="pKa_pH_WS_cell_K3" persistable="0" isFixedValue="0" formula="bd778ab2-1e13-4567-b30f-b995756ab942" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="ca08ee50-73a5-4834-ae8e-2f1d9468ef26" name="pKa_pH_WS_cell_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="bd778ab2-1e13-4567-b30f-b995756ab942" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="Neighborhood: Interstitial / Intracellular" />
@@ -2223,7 +2462,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="f4189715-a7ec-482c-b7c2-30b53a862d0e" name="pKa_pH_WS_cell_K4" persistable="0" isFixedValue="0" formula="1451dd34-ea64-49c3-8660-a8446938df7b" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="f4189715-a7ec-482c-b7c2-30b53a862d0e" name="pKa_pH_WS_cell_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="1451dd34-ea64-49c3-8660-a8446938df7b" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="Neighborhood: Interstitial / Intracellular" />
@@ -2231,7 +2472,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="b4b22e36-a2a7-479e-b7a8-7d9b1edbf89b" name="pKa_pH_WS_cell_K5" persistable="0" isFixedValue="0" formula="990fb9bb-fe8a-4de6-9fbc-fc031cbae9a3" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="b4b22e36-a2a7-479e-b7a8-7d9b1edbf89b" name="pKa_pH_WS_cell_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="990fb9bb-fe8a-4de6-9fbc-fc031cbae9a3" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="Neighborhood: Interstitial / Intracellular" />
@@ -2239,7 +2482,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="089ad420-b66b-4564-8b77-21f29a011d79" name="pKa_pH_WS_cell_K6" persistable="0" isFixedValue="0" formula="fe6a7da2-95bb-47bf-83d3-ce552bf99e4e" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="089ad420-b66b-4564-8b77-21f29a011d79" name="pKa_pH_WS_cell_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="fe6a7da2-95bb-47bf-83d3-ce552bf99e4e" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="Neighborhood: Interstitial / Intracellular" />
@@ -2247,7 +2492,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="d6179935-17c7-425f-848c-b56dfa4d4d5d" name="pKa_pH_WS_cell_K7" persistable="0" isFixedValue="0" formula="1c6dcfd4-fde6-424d-8fdb-e065c996e908" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="d6179935-17c7-425f-848c-b56dfa4d4d5d" name="pKa_pH_WS_cell_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="1c6dcfd4-fde6-424d-8fdb-e065c996e908" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="Neighborhood: Interstitial / Intracellular" />
@@ -2255,7 +2502,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="23941120-ce80-4514-869a-0216394c8c24" name="pKa_pH_WS_cell_K8" persistable="0" isFixedValue="0" formula="1241b44d-a850-4372-8734-b1d41cda65fe" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="23941120-ce80-4514-869a-0216394c8c24" name="pKa_pH_WS_cell_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="1241b44d-a850-4372-8734-b1d41cda65fe" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="Neighborhood: Interstitial / Intracellular" />
@@ -2265,7 +2514,7 @@
           </HelpParameters>
           <FormulaCache>
             <Formulas>
-              <Formula id="4151f90d-cbe1-409d-8498-885496894183" name="PARAM_K_a_PL_pH_Factor_BC" dim="Dimensionless" formula="K1+ K2* base ^ CT0 + K3* base ^ CT1+K4 *base^CT2 + K5* base ^ (CT0+CT1) +K6* base ^ (CT0+CT2) +K7* base ^ (CT2+CT1) +K8* base ^ (CT0+CT1+CT2)">
+              <Formula id="4151f90d-cbe1-409d-8498-885496894183" name="PARAM_K_a_PL_pH_Factor_BC" formula="K1+ K2* base ^ CT0 + K3* base ^ CT1+K4 *base^CT2 + K5* base ^ (CT0+CT1) +K6* base ^ (CT0+CT2) +K7* base ^ (CT2+CT1) +K8* base ^ (CT0+CT1+CT2)">
                 <Paths>
                   <Path path="37" as="38" />
                   <Path path="39" as="40" />
@@ -2281,7 +2530,7 @@
                   <Path path="59" as="60" />
                 </Paths>
               </Formula>
-              <Formula id="bd5b2b66-0b2e-47cc-80f2-feeeab38c854" name="PARAM_LogD_rbc" dim="Lipophilicity" formula="LogP+Log10(logD_Factor)">
+              <Formula id="bd5b2b66-0b2e-47cc-80f2-feeeab38c854" name="PARAM_LogD_rbc" dim="Log Units" formula="LogP+Log10(logD_Factor)">
                 <Paths>
                   <Path path="61" as="62" />
                   <Path path="3" as="63" dim="5" />
@@ -2291,7 +2540,7 @@
                   <Path path="70" as="71" />
                 </Paths>
               </Formula>
-              <Formula id="2cec3255-3dea-4534-95a6-ef59a7f0cff3" name="PARAM_logD_Factor_RBC" dim="Dimensionless" formula="K1+ (K2 +K3 +K4)* base ^ 1 + K5* base ^ max(CT0+CT1;-CT0-CT1) +K6* base ^ max(CT0+CT2;-CT0-CT2) +K7* base ^ max(CT2+CT1;-CT2-CT1) +K8* base ^ max(CT0+CT1+CT2;-CT0-CT1-CT2)">
+              <Formula id="2cec3255-3dea-4534-95a6-ef59a7f0cff3" name="PARAM_logD_Factor_RBC" formula="K1+ (K2 +K3 +K4)* base ^ 1 + K5* base ^ max(CT0+CT1;-CT0-CT1) +K6* base ^ max(CT0+CT2;-CT0-CT2) +K7* base ^ max(CT2+CT1;-CT2-CT1) +K8* base ^ max(CT0+CT1+CT2;-CT0-CT1-CT2)">
                 <Paths>
                   <Path path="72" as="38" />
                   <Path path="39" as="40" />
@@ -2307,7 +2556,7 @@
                   <Path path="59" as="60" />
                 </Paths>
               </Formula>
-              <Formula id="775cb5af-d8eb-420a-bfc9-e16550f3b7a1" name="PARAM_K_a_PL_rbc" dim="Dimensionless" formula="K_n_PL*K_a_PL_pH_Factor">
+              <Formula id="775cb5af-d8eb-420a-bfc9-e16550f3b7a1" name="PARAM_K_a_PL_rbc" formula="K_n_PL*K_a_PL_pH_Factor">
                 <Paths>
                   <Path path="73" as="74" />
                   <Path path="10" as="11" />
@@ -2317,17 +2566,17 @@
                   <Path path="70" as="71" />
                 </Paths>
               </Formula>
-              <Formula id="b8669309-c29f-4117-ab83-9f8ea4bc1cdc" name="PARAM_K_n_L_rbc" dim="Dimensionless" formula="10^LogD">
+              <Formula id="b8669309-c29f-4117-ab83-9f8ea4bc1cdc" name="PARAM_K_n_L_rbc" formula="10^LogD">
                 <Paths>
                   <Path path="75" as="76" dim="5" />
                 </Paths>
               </Formula>
-              <Formula id="8fb455a9-36c0-466c-8ce7-49c487e18094" name="PARAM_K_n_PL_rbc" dim="Dimensionless" formula="10^LogMA">
+              <Formula id="8fb455a9-36c0-466c-8ce7-49c487e18094" name="PARAM_K_n_PL_rbc" formula="10^LogMA">
                 <Paths>
                   <Path path="3" as="4" dim="5" />
                 </Paths>
               </Formula>
-              <Formula id="4b138d67-c6cf-47da-9f90-45b580ed280f" name="PARAM_pKa_pH_WS_bc_F1" dim="Dimensionless" formula="CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1">
+              <Formula id="4b138d67-c6cf-47da-9f90-45b580ed280f" name="PARAM_pKa_pH_WS_bc_F1" formula="CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1">
                 <Paths>
                   <Path path="39" as="40" />
                   <Path path="77" as="78" />
@@ -2335,7 +2584,7 @@
                   <Path path="70" as="80" />
                 </Paths>
               </Formula>
-              <Formula id="a5dd4192-1864-45a8-9b8e-141730dc47ee" name="PARAM_pKa_pH_WS_bc_F2" dim="Dimensionless" formula="CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1">
+              <Formula id="a5dd4192-1864-45a8-9b8e-141730dc47ee" name="PARAM_pKa_pH_WS_bc_F2" formula="CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1">
                 <Paths>
                   <Path path="41" as="42" />
                   <Path path="77" as="78" />
@@ -2343,7 +2592,7 @@
                   <Path path="70" as="80" />
                 </Paths>
               </Formula>
-              <Formula id="58957524-4efe-46c8-9d1c-942c92f4c78f" name="PARAM_pKa_pH_WS_bc_F3" dim="Dimensionless" formula="CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1">
+              <Formula id="58957524-4efe-46c8-9d1c-942c92f4c78f" name="PARAM_pKa_pH_WS_bc_F3" formula="CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1">
                 <Paths>
                   <Path path="43" as="44" />
                   <Path path="77" as="78" />
@@ -2351,63 +2600,63 @@
                   <Path path="70" as="80" />
                 </Paths>
               </Formula>
-              <Formula id="dcc40109-23cf-4adf-ae32-a4bce31bd74d" name="PARAM_pKa_pH_WS_bc_K1" dim="Dimensionless" formula="F1*F2*F3">
+              <Formula id="dcc40109-23cf-4adf-ae32-a4bce31bd74d" name="PARAM_pKa_pH_WS_bc_K1" formula="F1*F2*F3">
                 <Paths>
                   <Path path="83" as="84" />
                   <Path path="85" as="86" />
                   <Path path="87" as="88" />
                 </Paths>
               </Formula>
-              <Formula id="ee948a34-6a9c-4e4f-9748-c5a421e8ea9e" name="PARAM_pKa_pH_WS_bc_K2" dim="Dimensionless" formula="(1-F1)*F2*F3">
+              <Formula id="ee948a34-6a9c-4e4f-9748-c5a421e8ea9e" name="PARAM_pKa_pH_WS_bc_K2" formula="(1-F1)*F2*F3">
                 <Paths>
                   <Path path="83" as="84" />
                   <Path path="85" as="86" />
                   <Path path="87" as="88" />
                 </Paths>
               </Formula>
-              <Formula id="204b0782-551d-4ad1-889e-5078a4b0f0e7" name="PARAM_pKa_pH_WS_bc_K3" dim="Dimensionless" formula="F1*(1-F2)*F3">
+              <Formula id="204b0782-551d-4ad1-889e-5078a4b0f0e7" name="PARAM_pKa_pH_WS_bc_K3" formula="F1*(1-F2)*F3">
                 <Paths>
                   <Path path="83" as="84" />
                   <Path path="85" as="86" />
                   <Path path="87" as="88" />
                 </Paths>
               </Formula>
-              <Formula id="29dd0e1d-0a11-4eb1-b452-57489851a6ad" name="PARAM_pKa_pH_WS_bc_K4" dim="Dimensionless" formula="F1*F2*(1-F3)">
+              <Formula id="29dd0e1d-0a11-4eb1-b452-57489851a6ad" name="PARAM_pKa_pH_WS_bc_K4" formula="F1*F2*(1-F3)">
                 <Paths>
                   <Path path="83" as="84" />
                   <Path path="85" as="86" />
                   <Path path="87" as="88" />
                 </Paths>
               </Formula>
-              <Formula id="95db8b71-9f49-4856-9309-a1d2db666ede" name="PARAM_pKa_pH_WS_bc_K5" dim="Dimensionless" formula="(1-F1)*(1-F2)*F3">
+              <Formula id="95db8b71-9f49-4856-9309-a1d2db666ede" name="PARAM_pKa_pH_WS_bc_K5" formula="(1-F1)*(1-F2)*F3">
                 <Paths>
                   <Path path="83" as="84" />
                   <Path path="85" as="86" />
                   <Path path="87" as="88" />
                 </Paths>
               </Formula>
-              <Formula id="97d91e32-1c0a-474f-9a27-d89d76070410" name="PARAM_pKa_pH_WS_bc_K6" dim="Dimensionless" formula="(1-F1)*F2*(1-F3)">
+              <Formula id="97d91e32-1c0a-474f-9a27-d89d76070410" name="PARAM_pKa_pH_WS_bc_K6" formula="(1-F1)*F2*(1-F3)">
                 <Paths>
                   <Path path="83" as="84" />
                   <Path path="85" as="86" />
                   <Path path="87" as="88" />
                 </Paths>
               </Formula>
-              <Formula id="84538ce4-691f-4885-b026-1d4c8af7cf56" name="PARAM_pKa_pH_WS_bc_K7" dim="Dimensionless" formula="F1*(1-F2)*(1-F3)">
+              <Formula id="84538ce4-691f-4885-b026-1d4c8af7cf56" name="PARAM_pKa_pH_WS_bc_K7" formula="F1*(1-F2)*(1-F3)">
                 <Paths>
                   <Path path="83" as="84" />
                   <Path path="85" as="86" />
                   <Path path="87" as="88" />
                 </Paths>
               </Formula>
-              <Formula id="104dbb7c-4a1c-47dc-9422-3f2c69c2c582" name="PARAM_pKa_pH_WS_bc_K8" dim="Dimensionless" formula="(1-F1)*(1-F2)*(1-F3)">
+              <Formula id="104dbb7c-4a1c-47dc-9422-3f2c69c2c582" name="PARAM_pKa_pH_WS_bc_K8" formula="(1-F1)*(1-F2)*(1-F3)">
                 <Paths>
                   <Path path="83" as="84" />
                   <Path path="85" as="86" />
                   <Path path="87" as="88" />
                 </Paths>
               </Formula>
-              <Formula id="f1000e3e-620d-46de-b898-153d8e77a001" name="PARAM_K_a_PL_pH_Factor" dim="Dimensionless" formula="K1+ K2* base ^ CT0 + K3* base ^ CT1+K4 *base^CT2 + K5* base ^ (CT0+CT1) +K6* base ^ (CT0+CT2) +K7* base ^ (CT2+CT1) +K8* base ^ (CT0+CT1+CT2)">
+              <Formula id="f1000e3e-620d-46de-b898-153d8e77a001" name="PARAM_K_a_PL_pH_Factor" formula="K1+ K2* base ^ CT0 + K3* base ^ CT1+K4 *base^CT2 + K5* base ^ (CT0+CT1) +K6* base ^ (CT0+CT2) +K7* base ^ (CT2+CT1) +K8* base ^ (CT0+CT1+CT2)">
                 <Paths>
                   <Path path="89" as="46" />
                   <Path path="90" as="48" />
@@ -2423,7 +2672,7 @@
                   <Path path="100" as="44" />
                 </Paths>
               </Formula>
-              <Formula id="d4220058-900d-4978-8bfc-0713dfa5fea2" name="PARAM_LogD" dim="Lipophilicity" formula="LogP+Log10(logD_Factor)">
+              <Formula id="d4220058-900d-4978-8bfc-0713dfa5fea2" name="PARAM_LogD" dim="Log Units" formula="LogP+Log10(logD_Factor)">
                 <Paths>
                   <Path path="61" as="62" />
                   <Path path="3" as="63" dim="5" />
@@ -2433,7 +2682,7 @@
                   <Path path="101" as="102" />
                 </Paths>
               </Formula>
-              <Formula id="32ba85ae-ecd4-410b-ad18-abcb1378a594" name="PARAM_logD_Factor" dim="Dimensionless" formula="K1+ (K2 +K3 +K4)* base ^ 1 + K5* base ^ max(CT0+CT1;-CT0-CT1) +K6* base ^ max(CT0+CT2;-CT0-CT2) +K7* base ^ max(CT2+CT1;-CT2-CT1) +K8* base ^ max(CT0+CT1+CT2;-CT0-CT1-CT2)">
+              <Formula id="32ba85ae-ecd4-410b-ad18-abcb1378a594" name="PARAM_logD_Factor" formula="K1+ (K2 +K3 +K4)* base ^ 1 + K5* base ^ max(CT0+CT1;-CT0-CT1) +K6* base ^ max(CT0+CT2;-CT0-CT2) +K7* base ^ max(CT2+CT1;-CT2-CT1) +K8* base ^ max(CT0+CT1+CT2;-CT0-CT1-CT2)">
                 <Paths>
                   <Path path="89" as="46" />
                   <Path path="90" as="48" />
@@ -2449,7 +2698,7 @@
                   <Path path="100" as="44" />
                 </Paths>
               </Formula>
-              <Formula id="b4c1695c-1b12-46e5-9d2a-17f135600475" name="PARAM_K_a_PL" dim="Dimensionless" formula="K_n_PL*K_a_PL_pH_Factor">
+              <Formula id="b4c1695c-1b12-46e5-9d2a-17f135600475" name="PARAM_K_a_PL" formula="K_n_PL*K_a_PL_pH_Factor">
                 <Paths>
                   <Path path="73" as="74" />
                   <Path path="26" as="11" />
@@ -2459,17 +2708,17 @@
                   <Path path="101" as="102" />
                 </Paths>
               </Formula>
-              <Formula id="0a36f8b8-59f9-4cdb-a6eb-58687d717745" name="PARAM_K_n_L" dim="Dimensionless" formula="10^LogD">
+              <Formula id="0a36f8b8-59f9-4cdb-a6eb-58687d717745" name="PARAM_K_n_L" formula="10^LogD">
                 <Paths>
                   <Path path="104" as="76" dim="5" />
                 </Paths>
               </Formula>
-              <Formula id="461057fe-8457-4ac1-b9f7-140995b33f47" name="PARAM_K_n_PL" dim="Dimensionless" formula="10^LogMA">
+              <Formula id="461057fe-8457-4ac1-b9f7-140995b33f47" name="PARAM_K_n_PL" formula="10^LogMA">
                 <Paths>
                   <Path path="3" as="4" dim="5" />
                 </Paths>
               </Formula>
-              <Formula id="a69306a7-873d-4fb6-9d68-49b049f9d30a" name="PARAM_pKa_pH_WS_cell_F1" dim="Dimensionless" formula="CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1">
+              <Formula id="a69306a7-873d-4fb6-9d68-49b049f9d30a" name="PARAM_pKa_pH_WS_cell_F1" formula="CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1">
                 <Paths>
                   <Path path="105" as="80" />
                   <Path path="98" as="40" />
@@ -2477,7 +2726,7 @@
                   <Path path="64" as="65" />
                 </Paths>
               </Formula>
-              <Formula id="0365195c-5424-466a-894c-dd617bc08036" name="PARAM_pKa_pH_WS_cell_F2" dim="Dimensionless" formula="CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1">
+              <Formula id="0365195c-5424-466a-894c-dd617bc08036" name="PARAM_pKa_pH_WS_cell_F2" formula="CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1">
                 <Paths>
                   <Path path="105" as="80" />
                   <Path path="99" as="42" />
@@ -2485,7 +2734,7 @@
                   <Path path="66" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="5cf2da6b-5608-49ad-828f-9c15e2564c66" name="PARAM_pKa_pH_WS_cell_F3" dim="Dimensionless" formula="CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1">
+              <Formula id="5cf2da6b-5608-49ad-828f-9c15e2564c66" name="PARAM_pKa_pH_WS_cell_F3" formula="CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1">
                 <Paths>
                   <Path path="105" as="80" />
                   <Path path="100" as="44" />
@@ -2493,56 +2742,56 @@
                   <Path path="68" as="69" />
                 </Paths>
               </Formula>
-              <Formula id="ec7661e7-87c7-47da-9782-01b5a6a356a2" name="PARAM_pKa_pH_WS_cell_K1" dim="Dimensionless" formula="F1*F2*F3">
+              <Formula id="ec7661e7-87c7-47da-9782-01b5a6a356a2" name="PARAM_pKa_pH_WS_cell_K1" formula="F1*F2*F3">
                 <Paths>
                   <Path path="107" as="84" />
                   <Path path="108" as="86" />
                   <Path path="109" as="88" />
                 </Paths>
               </Formula>
-              <Formula id="65ba7f80-ef94-46ed-a707-da86eeacd4d4" name="PARAM_pKa_pH_WS_cell_K2" dim="Dimensionless" formula="(1-F1)*F2*F3">
+              <Formula id="65ba7f80-ef94-46ed-a707-da86eeacd4d4" name="PARAM_pKa_pH_WS_cell_K2" formula="(1-F1)*F2*F3">
                 <Paths>
                   <Path path="107" as="84" />
                   <Path path="108" as="86" />
                   <Path path="109" as="88" />
                 </Paths>
               </Formula>
-              <Formula id="bd778ab2-1e13-4567-b30f-b995756ab942" name="PARAM_pKa_pH_WS_cell_K3" dim="Dimensionless" formula="F1*(1-F2)*F3">
+              <Formula id="bd778ab2-1e13-4567-b30f-b995756ab942" name="PARAM_pKa_pH_WS_cell_K3" formula="F1*(1-F2)*F3">
                 <Paths>
                   <Path path="107" as="84" />
                   <Path path="108" as="86" />
                   <Path path="109" as="88" />
                 </Paths>
               </Formula>
-              <Formula id="1451dd34-ea64-49c3-8660-a8446938df7b" name="PARAM_pKa_pH_WS_cell_K4" dim="Dimensionless" formula="F1*F2*(1-F3)">
+              <Formula id="1451dd34-ea64-49c3-8660-a8446938df7b" name="PARAM_pKa_pH_WS_cell_K4" formula="F1*F2*(1-F3)">
                 <Paths>
                   <Path path="107" as="84" />
                   <Path path="108" as="86" />
                   <Path path="109" as="88" />
                 </Paths>
               </Formula>
-              <Formula id="990fb9bb-fe8a-4de6-9fbc-fc031cbae9a3" name="PARAM_pKa_pH_WS_cell_K5" dim="Dimensionless" formula="(1-F1)*(1-F2)*F3">
+              <Formula id="990fb9bb-fe8a-4de6-9fbc-fc031cbae9a3" name="PARAM_pKa_pH_WS_cell_K5" formula="(1-F1)*(1-F2)*F3">
                 <Paths>
                   <Path path="107" as="84" />
                   <Path path="108" as="86" />
                   <Path path="109" as="88" />
                 </Paths>
               </Formula>
-              <Formula id="fe6a7da2-95bb-47bf-83d3-ce552bf99e4e" name="PARAM_pKa_pH_WS_cell_K6" dim="Dimensionless" formula="(1-F1)*F2*(1-F3)">
+              <Formula id="fe6a7da2-95bb-47bf-83d3-ce552bf99e4e" name="PARAM_pKa_pH_WS_cell_K6" formula="(1-F1)*F2*(1-F3)">
                 <Paths>
                   <Path path="107" as="84" />
                   <Path path="108" as="86" />
                   <Path path="109" as="88" />
                 </Paths>
               </Formula>
-              <Formula id="1c6dcfd4-fde6-424d-8fdb-e065c996e908" name="PARAM_pKa_pH_WS_cell_K7" dim="Dimensionless" formula="F1*(1-F2)*(1-F3)">
+              <Formula id="1c6dcfd4-fde6-424d-8fdb-e065c996e908" name="PARAM_pKa_pH_WS_cell_K7" formula="F1*(1-F2)*(1-F3)">
                 <Paths>
                   <Path path="107" as="84" />
                   <Path path="108" as="86" />
                   <Path path="109" as="88" />
                 </Paths>
               </Formula>
-              <Formula id="1241b44d-a850-4372-8734-b1d41cda65fe" name="PARAM_pKa_pH_WS_cell_K8" dim="Dimensionless" formula="(1-F1)*(1-F2)*(1-F3)">
+              <Formula id="1241b44d-a850-4372-8734-b1d41cda65fe" name="PARAM_pKa_pH_WS_cell_K8" formula="(1-F1)*(1-F2)*(1-F3)">
                 <Paths>
                   <Path path="107" as="84" />
                   <Path path="108" as="86" />
@@ -2556,7 +2805,7 @@
               <Map s="Fraction" id="2" />
               <Map s="MOLECULE|Lipophilicity" id="3" />
               <Map s="LogMA" id="4" />
-              <Map s="Lipophilicity" id="5" />
+              <Map s="Log Units" id="5" />
               <Map s="MOLECULE|Partition coefficient (acidic phospholipids/blood cells water)" id="6" />
               <Map s="K_a_PL" id="7" />
               <Map s="MOLECULE|Partition coefficient (neutral lipids/blood cells water)" id="8" />
@@ -2664,10 +2913,11 @@
             </StringMap>
           </FormulaCache>
         </CoreCalculationMethod>
-        <CoreCalculationMethod id="647e8cae-1a83-4aa8-a01d-3696972610f3" name="Cellular permeability - PK-Sim Standard" category="DiffusionIntCell">
+        <CoreCalculationMethod id="647e8cae-1a83-4aa8-a01d-3696972610f3" name="Cellular permeability - PK-Sim Standard" icon="CoreCalculationMethod" bbVersion="0" category="DiffusionIntCell">
+          <Creation createdAt="5248846133421212620" createdBy="Michael" creationMode="New" origin="Other" />
           <OutputFormulas>
             <KeyValue>
-              <ConstantFormula id="873ed751-6ef4-46f7-b995-3011746ec04a" dim="Dimensionless" value="1" />
+              <ConstantFormula id="873ed751-6ef4-46f7-b995-3011746ec04a" value="1" />
               <ParameterDescriptor parameterName="P_bc_pls_factor">
                 <ContainerCriteria>
                   <DescriptorConditions>
@@ -2677,7 +2927,7 @@
               </ParameterDescriptor>
             </KeyValue>
             <KeyValue>
-              <ConstantFormula id="cf44f5ee-74b7-42e2-a687-5f0ae670c659" dim="Dimensionless" value="1" />
+              <ConstantFormula id="cf44f5ee-74b7-42e2-a687-5f0ae670c659" value="1" />
               <ParameterDescriptor parameterName="P_pls_bc_factor">
                 <ContainerCriteria>
                   <DescriptorConditions>
@@ -2687,7 +2937,7 @@
               </ParameterDescriptor>
             </KeyValue>
             <KeyValue>
-              <ConstantFormula id="c7b7034c-c5d3-4444-ab45-01de33111de1" dim="Dimensionless" value="1" />
+              <ConstantFormula id="c7b7034c-c5d3-4444-ab45-01de33111de1" value="1" />
               <ParameterDescriptor parameterName="P_cell_int_factor">
                 <ContainerCriteria>
                   <DescriptorConditions>
@@ -2697,7 +2947,7 @@
               </ParameterDescriptor>
             </KeyValue>
             <KeyValue>
-              <ConstantFormula id="e0368f94-1da1-4f3f-b5a5-ed9220f6e8f5" dim="Dimensionless" value="1" />
+              <ConstantFormula id="e0368f94-1da1-4f3f-b5a5-ed9220f6e8f5" value="1" />
               <ParameterDescriptor parameterName="P_int_cell_factor">
                 <ContainerCriteria>
                   <DescriptorConditions>
@@ -2708,14 +2958,12 @@
             </KeyValue>
           </OutputFormulas>
           <HelpParameters />
-          <FormulaCache>
-            <StringMap />
-          </FormulaCache>
         </CoreCalculationMethod>
-        <CoreCalculationMethod id="811c7570-df85-46c7-a3d4-be3b0d8e1141" name="Cellular permeability - Charge dependent Schmitt" category="DiffusionIntCell">
+        <CoreCalculationMethod id="811c7570-df85-46c7-a3d4-be3b0d8e1141" name="Cellular permeability - Charge dependent Schmitt" icon="CoreCalculationMethod" bbVersion="0" category="DiffusionIntCell">
+          <Creation createdAt="5248846133421212620" createdBy="Michael" creationMode="New" origin="Other" />
           <OutputFormulas>
             <KeyValue>
-              <Formula id="5c7aae7b-50f6-4d4a-89d2-0a0ab84bdf6a" name="PARAM_P_rbc_pls_factor_WS" dim="Dimensionless" formula="K1+ (K2 +K3 +K4)* base ^ 1 + K5* base ^ max(CT0+CT1;-CT0-CT1) +K6* base ^ max(CT0+CT2;-CT0-CT2) +K7* base ^ max(CT2+CT1;-CT2-CT1) +K8* base ^ max(CT0+CT1+CT2;-CT0-CT1-CT2)">
+              <Formula id="5c7aae7b-50f6-4d4a-89d2-0a0ab84bdf6a" name="PARAM_P_rbc_pls_factor_WS" formula="K1+ (K2 +K3 +K4)* base ^ 1 + K5* base ^ max(CT0+CT1;-CT0-CT1) +K6* base ^ max(CT0+CT2;-CT0-CT2) +K7* base ^ max(CT2+CT1;-CT2-CT1) +K8* base ^ max(CT0+CT1+CT2;-CT0-CT1-CT2)">
                 <Paths>
                   <Path path="0" as="1" />
                   <Path path="2" as="3" />
@@ -2740,7 +2988,7 @@
               </ParameterDescriptor>
             </KeyValue>
             <KeyValue>
-              <Formula id="95e17f7e-22cd-4620-8c7b-786a912ef607" name="PARAM_P_pls_rbc_factor_WS" dim="Dimensionless" formula="K1+ (K2 +K3 +K4)* base ^ 1 + K5* base ^ max(CT0+CT1;-CT0-CT1) +K6* base ^ max(CT0+CT2;-CT0-CT2) +K7* base ^ max(CT2+CT1;-CT2-CT1) +K8* base ^ max(CT0+CT1+CT2;-CT0-CT1-CT2)">
+              <Formula id="95e17f7e-22cd-4620-8c7b-786a912ef607" name="PARAM_P_pls_rbc_factor_WS" formula="K1+ (K2 +K3 +K4)* base ^ 1 + K5* base ^ max(CT0+CT1;-CT0-CT1) +K6* base ^ max(CT0+CT2;-CT0-CT2) +K7* base ^ max(CT2+CT1;-CT2-CT1) +K8* base ^ max(CT0+CT1+CT2;-CT0-CT1-CT2)">
                 <Paths>
                   <Path path="0" as="1" />
                   <Path path="2" as="3" />
@@ -2765,7 +3013,7 @@
               </ParameterDescriptor>
             </KeyValue>
             <KeyValue>
-              <Formula id="9528ed60-34ca-487f-8b7e-6e059096bd5d" name="PARAM_P_cell_int_factor_WS" dim="Dimensionless" formula="K1+ (K2 +K3 +K4)* base ^ 1 + K5* base ^ max(CT0+CT1;-CT0-CT1) +K6* base ^ max(CT0+CT2;-CT0-CT2) +K7* base ^ max(CT2+CT1;-CT2-CT1) +K8* base ^ max(CT0+CT1+CT2;-CT0-CT1-CT2)">
+              <Formula id="9528ed60-34ca-487f-8b7e-6e059096bd5d" name="PARAM_P_cell_int_factor_WS" formula="K1+ (K2 +K3 +K4)* base ^ 1 + K5* base ^ max(CT0+CT1;-CT0-CT1) +K6* base ^ max(CT0+CT2;-CT0-CT2) +K7* base ^ max(CT2+CT1;-CT2-CT1) +K8* base ^ max(CT0+CT1+CT2;-CT0-CT1-CT2)">
                 <Paths>
                   <Path path="32" as="9" />
                   <Path path="33" as="11" />
@@ -2790,7 +3038,7 @@
               </ParameterDescriptor>
             </KeyValue>
             <KeyValue>
-              <Formula id="ed4ca6c8-9013-47c3-b1ab-daa41eb7ad74" name="PARAM_P_int_cell_factor_WS" dim="Dimensionless" formula="K1+ (K2 +K3 +K4)* base ^ 1 + K5* base ^ max(CT0+CT1;-CT0-CT1) +K6* base ^ max(CT0+CT2;-CT0-CT2) +K7* base ^ max(CT2+CT1;-CT2-CT1) +K8* base ^ max(CT0+CT1+CT2;-CT0-CT1-CT2)">
+              <Formula id="ed4ca6c8-9013-47c3-b1ab-daa41eb7ad74" name="PARAM_P_int_cell_factor_WS" formula="K1+ (K2 +K3 +K4)* base ^ 1 + K5* base ^ max(CT0+CT1;-CT0-CT1) +K6* base ^ max(CT0+CT2;-CT0-CT2) +K7* base ^ max(CT2+CT1;-CT2-CT1) +K8* base ^ max(CT0+CT1+CT2;-CT0-CT1-CT2)">
                 <Paths>
                   <Path path="44" as="9" />
                   <Path path="45" as="11" />
@@ -2817,7 +3065,9 @@
           </OutputFormulas>
           <HelpParameters>
             <KeyValue>
-              <Parameter id="45088bca-39e2-4c07-9600-1a95628c8e69" name="pKa_pH_WS_bc_F1" persistable="0" isFixedValue="0" formula="211fd128-818a-4517-aa31-9212850a094e" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="45088bca-39e2-4c07-9600-1a95628c8e69" name="pKa_pH_WS_bc_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="211fd128-818a-4517-aa31-9212850a094e" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -2825,7 +3075,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="ba1bcf92-72ea-4be8-9507-63acafb8af95" name="pKa_pH_WS_bc_F2" persistable="0" isFixedValue="0" formula="fc195ccd-7d04-4548-afcd-2951991fb1f6" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="ba1bcf92-72ea-4be8-9507-63acafb8af95" name="pKa_pH_WS_bc_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="fc195ccd-7d04-4548-afcd-2951991fb1f6" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -2833,7 +3085,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="7437b3aa-d327-41bb-ba12-2f783916849b" name="pKa_pH_WS_bc_F3" persistable="0" isFixedValue="0" formula="27c17fa9-e106-4a5b-af4d-6ba2741fb2b6" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="7437b3aa-d327-41bb-ba12-2f783916849b" name="pKa_pH_WS_bc_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="27c17fa9-e106-4a5b-af4d-6ba2741fb2b6" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -2841,7 +3095,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="2374d409-09a0-40ff-bf24-0330e307327a" name="pKa_pH_WS_bc_K1" persistable="0" isFixedValue="0" formula="ba238084-a227-44b3-beba-2755ee5d5be7" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="2374d409-09a0-40ff-bf24-0330e307327a" name="pKa_pH_WS_bc_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ba238084-a227-44b3-beba-2755ee5d5be7" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -2849,7 +3105,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="11f98a32-6bfa-4821-a903-53c6bb20de78" name="pKa_pH_WS_bc_K2" persistable="0" isFixedValue="0" formula="7df9a226-acbb-4562-8d81-b1de7c233aa5" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="11f98a32-6bfa-4821-a903-53c6bb20de78" name="pKa_pH_WS_bc_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="7df9a226-acbb-4562-8d81-b1de7c233aa5" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -2857,7 +3115,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="60108c1b-5b03-4327-8c02-2364a8c8c89e" name="pKa_pH_WS_bc_K3" persistable="0" isFixedValue="0" formula="b77d708d-b018-4e08-8caf-5c93125ab01a" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="60108c1b-5b03-4327-8c02-2364a8c8c89e" name="pKa_pH_WS_bc_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="b77d708d-b018-4e08-8caf-5c93125ab01a" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -2865,7 +3125,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="d72bd39c-324b-42b1-a39d-cacd9e9f5195" name="pKa_pH_WS_bc_K4" persistable="0" isFixedValue="0" formula="fe691aef-e452-421f-ac6a-30f4b6a4b0db" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="d72bd39c-324b-42b1-a39d-cacd9e9f5195" name="pKa_pH_WS_bc_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="fe691aef-e452-421f-ac6a-30f4b6a4b0db" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -2873,7 +3135,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="e64effe6-222e-4e9e-98e9-a2775e7345a4" name="pKa_pH_WS_bc_K5" persistable="0" isFixedValue="0" formula="8960ad6e-e7dd-4e27-838f-0fc233e09069" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="e64effe6-222e-4e9e-98e9-a2775e7345a4" name="pKa_pH_WS_bc_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="8960ad6e-e7dd-4e27-838f-0fc233e09069" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -2881,7 +3145,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="013692b7-90c3-40dd-b985-555d7d9953b5" name="pKa_pH_WS_bc_K6" persistable="0" isFixedValue="0" formula="2242b7f0-c6c6-4d12-9619-c58e36e102cf" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="013692b7-90c3-40dd-b985-555d7d9953b5" name="pKa_pH_WS_bc_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="2242b7f0-c6c6-4d12-9619-c58e36e102cf" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -2889,7 +3155,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="b52b55a9-184e-43b1-8d49-f313901cc89b" name="pKa_pH_WS_bc_K7" persistable="0" isFixedValue="0" formula="447e2b9e-20ad-4e9a-903b-534776c83d07" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="b52b55a9-184e-43b1-8d49-f313901cc89b" name="pKa_pH_WS_bc_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="447e2b9e-20ad-4e9a-903b-534776c83d07" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -2897,7 +3165,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="467b6328-608a-46a3-8678-2282107487b7" name="pKa_pH_WS_bc_K8" persistable="0" isFixedValue="0" formula="dfd6d7ed-1474-4b21-89ec-d0d92f3581a6" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="467b6328-608a-46a3-8678-2282107487b7" name="pKa_pH_WS_bc_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="dfd6d7ed-1474-4b21-89ec-d0d92f3581a6" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -2905,7 +3175,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="36531764-5f45-49d3-a0a6-1b635f0186c6" name="pKa_pH_WS_pls_F1" persistable="0" isFixedValue="0" formula="421a1068-39dc-43cc-90e3-15bb847d04e4" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="36531764-5f45-49d3-a0a6-1b635f0186c6" name="pKa_pH_WS_pls_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="421a1068-39dc-43cc-90e3-15bb847d04e4" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -2913,7 +3185,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="3f7fe299-c45d-4b15-9a7b-a9ec134b7abb" name="pKa_pH_WS_pls_F2" persistable="0" isFixedValue="0" formula="67b6741f-d337-4e42-a35e-0e145400eb60" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="3f7fe299-c45d-4b15-9a7b-a9ec134b7abb" name="pKa_pH_WS_pls_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="67b6741f-d337-4e42-a35e-0e145400eb60" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -2921,7 +3195,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="38ff5e2e-3ddb-4d4b-8cb1-cb8b178beb33" name="pKa_pH_WS_pls_F3" persistable="0" isFixedValue="0" formula="8806016d-c22d-4974-ab1c-98a21396d378" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="38ff5e2e-3ddb-4d4b-8cb1-cb8b178beb33" name="pKa_pH_WS_pls_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="8806016d-c22d-4974-ab1c-98a21396d378" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -2929,7 +3205,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="8d5c30eb-1545-41c7-9c50-8716f253fb43" name="pKa_pH_WS_pls_K1" persistable="0" isFixedValue="0" formula="15071fe6-742e-494c-a60a-da8e8ddd4f7c" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="8d5c30eb-1545-41c7-9c50-8716f253fb43" name="pKa_pH_WS_pls_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="15071fe6-742e-494c-a60a-da8e8ddd4f7c" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -2937,7 +3215,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="21e1121a-14c3-4ee7-9b8f-d4d53a609a4b" name="pKa_pH_WS_pls_K2" persistable="0" isFixedValue="0" formula="50da2fa1-e86a-4397-8a0a-0f5621907c9f" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="21e1121a-14c3-4ee7-9b8f-d4d53a609a4b" name="pKa_pH_WS_pls_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="50da2fa1-e86a-4397-8a0a-0f5621907c9f" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -2945,7 +3225,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="4446cd9d-bbe0-4c6b-8aa5-7e361133c522" name="pKa_pH_WS_pls_K3" persistable="0" isFixedValue="0" formula="0b1897f3-e560-4a6d-907c-b07477c32e1f" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="4446cd9d-bbe0-4c6b-8aa5-7e361133c522" name="pKa_pH_WS_pls_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="0b1897f3-e560-4a6d-907c-b07477c32e1f" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -2953,7 +3235,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="89fce047-7be5-4900-8133-b5c894de27fe" name="pKa_pH_WS_pls_K4" persistable="0" isFixedValue="0" formula="3c5083d5-0844-4b7a-ab51-2eaa216eb39d" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="89fce047-7be5-4900-8133-b5c894de27fe" name="pKa_pH_WS_pls_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="3c5083d5-0844-4b7a-ab51-2eaa216eb39d" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -2961,7 +3245,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="860cc3a6-0f48-4246-83b3-1db6dfb2c3c0" name="pKa_pH_WS_pls_K5" persistable="0" isFixedValue="0" formula="68e21329-d360-4215-86b1-bb307662c85b" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="860cc3a6-0f48-4246-83b3-1db6dfb2c3c0" name="pKa_pH_WS_pls_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="68e21329-d360-4215-86b1-bb307662c85b" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -2969,7 +3255,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="a98d47d4-8beb-4bd8-949d-61b5ac599bd4" name="pKa_pH_WS_pls_K6" persistable="0" isFixedValue="0" formula="b7334d1d-7f98-4887-8eaa-2548b68694f4" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="a98d47d4-8beb-4bd8-949d-61b5ac599bd4" name="pKa_pH_WS_pls_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="b7334d1d-7f98-4887-8eaa-2548b68694f4" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -2977,7 +3265,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="aa579e66-998f-4cd1-90d1-8d9d49dff601" name="pKa_pH_WS_pls_K7" persistable="0" isFixedValue="0" formula="69209dc5-6b6f-49dd-beb8-37339c4f6886" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="aa579e66-998f-4cd1-90d1-8d9d49dff601" name="pKa_pH_WS_pls_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="69209dc5-6b6f-49dd-beb8-37339c4f6886" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -2985,7 +3275,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="4a610093-fca4-4c33-937d-e14f650f5524" name="pKa_pH_WS_pls_K8" persistable="0" isFixedValue="0" formula="88bf1db6-8532-4b06-8b50-7313a8be8c87" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="4a610093-fca4-4c33-937d-e14f650f5524" name="pKa_pH_WS_pls_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="88bf1db6-8532-4b06-8b50-7313a8be8c87" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -2993,7 +3285,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="5181db2d-585f-42fe-ae3d-08b585634aaa" name="pKa_pH_WS_cell_F1" persistable="0" isFixedValue="0" formula="83e223a5-a86b-437c-b0c0-cc8e3c1410ed" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="5181db2d-585f-42fe-ae3d-08b585634aaa" name="pKa_pH_WS_cell_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="83e223a5-a86b-437c-b0c0-cc8e3c1410ed" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="Neighborhood: Interstitial / Intracellular" />
@@ -3001,7 +3295,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="cd617819-5bf9-4983-ab74-3031f21e6177" name="pKa_pH_WS_cell_F2" persistable="0" isFixedValue="0" formula="9b431abd-e0ba-4ff1-b1f0-2357edbd7a40" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="cd617819-5bf9-4983-ab74-3031f21e6177" name="pKa_pH_WS_cell_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="9b431abd-e0ba-4ff1-b1f0-2357edbd7a40" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="Neighborhood: Interstitial / Intracellular" />
@@ -3009,7 +3305,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="08dc1431-1cc5-495a-b32d-65076ec28438" name="pKa_pH_WS_cell_F3" persistable="0" isFixedValue="0" formula="94d08a64-9ebe-4641-8225-2c8ca91ed204" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="08dc1431-1cc5-495a-b32d-65076ec28438" name="pKa_pH_WS_cell_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="94d08a64-9ebe-4641-8225-2c8ca91ed204" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="Neighborhood: Interstitial / Intracellular" />
@@ -3017,7 +3315,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="71a69a37-6360-44b7-8268-94dfdff18ff1" name="pKa_pH_WS_cell_K1" persistable="0" isFixedValue="0" formula="21c3701f-11bb-4b62-9a2b-93cedaf65f4f" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="71a69a37-6360-44b7-8268-94dfdff18ff1" name="pKa_pH_WS_cell_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="21c3701f-11bb-4b62-9a2b-93cedaf65f4f" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="Neighborhood: Interstitial / Intracellular" />
@@ -3025,7 +3325,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="f3df6b12-3a43-4b67-8948-aa3b96d3ab86" name="pKa_pH_WS_cell_K2" persistable="0" isFixedValue="0" formula="74fd7fc8-0ee1-4f19-a4aa-26140f206896" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="f3df6b12-3a43-4b67-8948-aa3b96d3ab86" name="pKa_pH_WS_cell_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="74fd7fc8-0ee1-4f19-a4aa-26140f206896" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="Neighborhood: Interstitial / Intracellular" />
@@ -3033,7 +3335,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="b54fed7f-0a18-4085-ac1c-8ec4527dc780" name="pKa_pH_WS_cell_K3" persistable="0" isFixedValue="0" formula="339c6506-bbce-4585-a801-c612cd6140cc" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="b54fed7f-0a18-4085-ac1c-8ec4527dc780" name="pKa_pH_WS_cell_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="339c6506-bbce-4585-a801-c612cd6140cc" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="Neighborhood: Interstitial / Intracellular" />
@@ -3041,7 +3345,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="737e59e4-9a24-4f94-83c8-b55be8041964" name="pKa_pH_WS_cell_K4" persistable="0" isFixedValue="0" formula="47f2aaf5-c91f-4fe1-8e6c-3a4b3074fe22" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="737e59e4-9a24-4f94-83c8-b55be8041964" name="pKa_pH_WS_cell_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="47f2aaf5-c91f-4fe1-8e6c-3a4b3074fe22" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="Neighborhood: Interstitial / Intracellular" />
@@ -3049,7 +3355,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="5f6ee8cf-7834-4b91-8e09-8a4baa855fdd" name="pKa_pH_WS_cell_K5" persistable="0" isFixedValue="0" formula="d62185a7-1be4-42ea-b68a-9cbaf09fbdf1" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="5f6ee8cf-7834-4b91-8e09-8a4baa855fdd" name="pKa_pH_WS_cell_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="d62185a7-1be4-42ea-b68a-9cbaf09fbdf1" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="Neighborhood: Interstitial / Intracellular" />
@@ -3057,7 +3365,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="debf6d22-63db-46b0-bc91-bb8d906875a2" name="pKa_pH_WS_cell_K6" persistable="0" isFixedValue="0" formula="42bc4456-7f99-454d-810a-8362c6ad04a9" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="debf6d22-63db-46b0-bc91-bb8d906875a2" name="pKa_pH_WS_cell_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="42bc4456-7f99-454d-810a-8362c6ad04a9" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="Neighborhood: Interstitial / Intracellular" />
@@ -3065,7 +3375,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="18f233e4-2613-4336-9e54-fd4ae4291495" name="pKa_pH_WS_cell_K7" persistable="0" isFixedValue="0" formula="c3a95cc1-fe8c-48b1-9bd7-698275512eab" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="18f233e4-2613-4336-9e54-fd4ae4291495" name="pKa_pH_WS_cell_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="c3a95cc1-fe8c-48b1-9bd7-698275512eab" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="Neighborhood: Interstitial / Intracellular" />
@@ -3073,7 +3385,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="f1c77b5f-290e-43c5-b9ab-886f38916cc1" name="pKa_pH_WS_cell_K8" persistable="0" isFixedValue="0" formula="ec6bafae-c7eb-47dd-a411-c2fd85325626" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="f1c77b5f-290e-43c5-b9ab-886f38916cc1" name="pKa_pH_WS_cell_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ec6bafae-c7eb-47dd-a411-c2fd85325626" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="Neighborhood: Interstitial / Intracellular" />
@@ -3081,7 +3395,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="fe74239c-3b23-41d8-a008-8cd221d994c8" name="pKa_pH_WS_int_F1" persistable="0" isFixedValue="0" formula="d8023aa8-9188-481c-845b-4a244cdaaa16" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="fe74239c-3b23-41d8-a008-8cd221d994c8" name="pKa_pH_WS_int_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="d8023aa8-9188-481c-845b-4a244cdaaa16" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="Neighborhood: Interstitial / Intracellular" />
@@ -3089,7 +3405,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="d63270b5-813f-4422-ae1f-aa4602795277" name="pKa_pH_WS_int_F2" persistable="0" isFixedValue="0" formula="217ffd16-92da-4826-bc05-fd5c435e1c79" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="d63270b5-813f-4422-ae1f-aa4602795277" name="pKa_pH_WS_int_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="217ffd16-92da-4826-bc05-fd5c435e1c79" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="Neighborhood: Interstitial / Intracellular" />
@@ -3097,7 +3415,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="51f5c6e9-7c14-4c74-bbc2-927a9db0f090" name="pKa_pH_WS_int_F3" persistable="0" isFixedValue="0" formula="2540fe6f-35a0-4366-b717-9c3276659c15" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="51f5c6e9-7c14-4c74-bbc2-927a9db0f090" name="pKa_pH_WS_int_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="2540fe6f-35a0-4366-b717-9c3276659c15" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="Neighborhood: Interstitial / Intracellular" />
@@ -3105,7 +3425,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="bce8da91-f041-44bf-a353-20574581c00a" name="pKa_pH_WS_int_K1" persistable="0" isFixedValue="0" formula="33a33c98-fa6b-434f-a40a-0a4bf5d5e958" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="bce8da91-f041-44bf-a353-20574581c00a" name="pKa_pH_WS_int_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="33a33c98-fa6b-434f-a40a-0a4bf5d5e958" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="Neighborhood: Interstitial / Intracellular" />
@@ -3113,7 +3435,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="0365e295-1be5-4444-b4ac-ffd3d3a265ab" name="pKa_pH_WS_int_K2" persistable="0" isFixedValue="0" formula="4678d099-f1ae-485d-9c5d-f33b3f42ee5a" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="0365e295-1be5-4444-b4ac-ffd3d3a265ab" name="pKa_pH_WS_int_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="4678d099-f1ae-485d-9c5d-f33b3f42ee5a" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="Neighborhood: Interstitial / Intracellular" />
@@ -3121,7 +3445,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="204d2b6f-fa49-41b3-95d2-47f4c0040c3e" name="pKa_pH_WS_int_K3" persistable="0" isFixedValue="0" formula="6dd92aff-d107-492c-b704-472476087b8e" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="204d2b6f-fa49-41b3-95d2-47f4c0040c3e" name="pKa_pH_WS_int_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="6dd92aff-d107-492c-b704-472476087b8e" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="Neighborhood: Interstitial / Intracellular" />
@@ -3129,7 +3455,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="7e62b69c-cf29-471b-8cc3-452a129faf20" name="pKa_pH_WS_int_K4" persistable="0" isFixedValue="0" formula="a1dee693-2ff7-4fb3-a138-210811538646" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="7e62b69c-cf29-471b-8cc3-452a129faf20" name="pKa_pH_WS_int_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="a1dee693-2ff7-4fb3-a138-210811538646" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="Neighborhood: Interstitial / Intracellular" />
@@ -3137,7 +3465,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="dcbf7705-7a01-4a38-882f-cd3935ef628e" name="pKa_pH_WS_int_K5" persistable="0" isFixedValue="0" formula="8d02c63c-d1aa-454f-9100-431045826417" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="dcbf7705-7a01-4a38-882f-cd3935ef628e" name="pKa_pH_WS_int_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="8d02c63c-d1aa-454f-9100-431045826417" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="Neighborhood: Interstitial / Intracellular" />
@@ -3145,7 +3475,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="418d9615-a158-469e-a79d-4012f647a618" name="pKa_pH_WS_int_K6" persistable="0" isFixedValue="0" formula="39433164-c09e-44aa-aa89-f7cbc4a6fa5e" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="418d9615-a158-469e-a79d-4012f647a618" name="pKa_pH_WS_int_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="39433164-c09e-44aa-aa89-f7cbc4a6fa5e" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="Neighborhood: Interstitial / Intracellular" />
@@ -3153,7 +3485,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="d5e231d3-578a-4aff-b3a6-de52bacb5458" name="pKa_pH_WS_int_K7" persistable="0" isFixedValue="0" formula="50fdc2f0-5db3-4549-b188-fc652a9eb411" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="d5e231d3-578a-4aff-b3a6-de52bacb5458" name="pKa_pH_WS_int_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="50fdc2f0-5db3-4549-b188-fc652a9eb411" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="Neighborhood: Interstitial / Intracellular" />
@@ -3161,7 +3495,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="2517eef7-0cee-4651-a2b2-4cf96272c74c" name="pKa_pH_WS_int_K8" persistable="0" isFixedValue="0" formula="a408ed0d-d527-4ade-9125-89dcd556d23f" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="2517eef7-0cee-4651-a2b2-4cf96272c74c" name="pKa_pH_WS_int_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="a408ed0d-d527-4ade-9125-89dcd556d23f" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="Neighborhood: Interstitial / Intracellular" />
@@ -3171,7 +3507,7 @@
           </HelpParameters>
           <FormulaCache>
             <Formulas>
-              <Formula id="211fd128-818a-4517-aa31-9212850a094e" name="PARAM_pKa_pH_WS_bc_F1" dim="Dimensionless" formula="CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1">
+              <Formula id="211fd128-818a-4517-aa31-9212850a094e" name="PARAM_pKa_pH_WS_bc_F1" formula="CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1">
                 <Paths>
                   <Path path="2" as="3" />
                   <Path path="52" as="53" />
@@ -3179,7 +3515,7 @@
                   <Path path="56" as="57" />
                 </Paths>
               </Formula>
-              <Formula id="fc195ccd-7d04-4548-afcd-2951991fb1f6" name="PARAM_pKa_pH_WS_bc_F2" dim="Dimensionless" formula="CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1">
+              <Formula id="fc195ccd-7d04-4548-afcd-2951991fb1f6" name="PARAM_pKa_pH_WS_bc_F2" formula="CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1">
                 <Paths>
                   <Path path="4" as="5" />
                   <Path path="52" as="53" />
@@ -3187,7 +3523,7 @@
                   <Path path="56" as="57" />
                 </Paths>
               </Formula>
-              <Formula id="27c17fa9-e106-4a5b-af4d-6ba2741fb2b6" name="PARAM_pKa_pH_WS_bc_F3" dim="Dimensionless" formula="CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1">
+              <Formula id="27c17fa9-e106-4a5b-af4d-6ba2741fb2b6" name="PARAM_pKa_pH_WS_bc_F3" formula="CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1">
                 <Paths>
                   <Path path="6" as="7" />
                   <Path path="52" as="53" />
@@ -3195,63 +3531,63 @@
                   <Path path="56" as="57" />
                 </Paths>
               </Formula>
-              <Formula id="ba238084-a227-44b3-beba-2755ee5d5be7" name="PARAM_pKa_pH_WS_bc_K1" dim="Dimensionless" formula="F1*F2*F3">
+              <Formula id="ba238084-a227-44b3-beba-2755ee5d5be7" name="PARAM_pKa_pH_WS_bc_K1" formula="F1*F2*F3">
                 <Paths>
                   <Path path="62" as="63" />
                   <Path path="64" as="65" />
                   <Path path="66" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="7df9a226-acbb-4562-8d81-b1de7c233aa5" name="PARAM_pKa_pH_WS_bc_K2" dim="Dimensionless" formula="(1-F1)*F2*F3">
+              <Formula id="7df9a226-acbb-4562-8d81-b1de7c233aa5" name="PARAM_pKa_pH_WS_bc_K2" formula="(1-F1)*F2*F3">
                 <Paths>
                   <Path path="62" as="63" />
                   <Path path="64" as="65" />
                   <Path path="66" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="b77d708d-b018-4e08-8caf-5c93125ab01a" name="PARAM_pKa_pH_WS_bc_K3" dim="Dimensionless" formula="F1*(1-F2)*F3">
+              <Formula id="b77d708d-b018-4e08-8caf-5c93125ab01a" name="PARAM_pKa_pH_WS_bc_K3" formula="F1*(1-F2)*F3">
                 <Paths>
                   <Path path="62" as="63" />
                   <Path path="64" as="65" />
                   <Path path="66" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="fe691aef-e452-421f-ac6a-30f4b6a4b0db" name="PARAM_pKa_pH_WS_bc_K4" dim="Dimensionless" formula="F1*F2*(1-F3)">
+              <Formula id="fe691aef-e452-421f-ac6a-30f4b6a4b0db" name="PARAM_pKa_pH_WS_bc_K4" formula="F1*F2*(1-F3)">
                 <Paths>
                   <Path path="62" as="63" />
                   <Path path="64" as="65" />
                   <Path path="66" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="8960ad6e-e7dd-4e27-838f-0fc233e09069" name="PARAM_pKa_pH_WS_bc_K5" dim="Dimensionless" formula="(1-F1)*(1-F2)*F3">
+              <Formula id="8960ad6e-e7dd-4e27-838f-0fc233e09069" name="PARAM_pKa_pH_WS_bc_K5" formula="(1-F1)*(1-F2)*F3">
                 <Paths>
                   <Path path="62" as="63" />
                   <Path path="64" as="65" />
                   <Path path="66" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="2242b7f0-c6c6-4d12-9619-c58e36e102cf" name="PARAM_pKa_pH_WS_bc_K6" dim="Dimensionless" formula="(1-F1)*F2*(1-F3)">
+              <Formula id="2242b7f0-c6c6-4d12-9619-c58e36e102cf" name="PARAM_pKa_pH_WS_bc_K6" formula="(1-F1)*F2*(1-F3)">
                 <Paths>
                   <Path path="62" as="63" />
                   <Path path="64" as="65" />
                   <Path path="66" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="447e2b9e-20ad-4e9a-903b-534776c83d07" name="PARAM_pKa_pH_WS_bc_K7" dim="Dimensionless" formula="F1*(1-F2)*(1-F3)">
+              <Formula id="447e2b9e-20ad-4e9a-903b-534776c83d07" name="PARAM_pKa_pH_WS_bc_K7" formula="F1*(1-F2)*(1-F3)">
                 <Paths>
                   <Path path="62" as="63" />
                   <Path path="64" as="65" />
                   <Path path="66" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="dfd6d7ed-1474-4b21-89ec-d0d92f3581a6" name="PARAM_pKa_pH_WS_bc_K8" dim="Dimensionless" formula="(1-F1)*(1-F2)*(1-F3)">
+              <Formula id="dfd6d7ed-1474-4b21-89ec-d0d92f3581a6" name="PARAM_pKa_pH_WS_bc_K8" formula="(1-F1)*(1-F2)*(1-F3)">
                 <Paths>
                   <Path path="62" as="63" />
                   <Path path="64" as="65" />
                   <Path path="66" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="421a1068-39dc-43cc-90e3-15bb847d04e4" name="PARAM_pKa_pH_WS_pls_F1" dim="Dimensionless" formula="CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1">
+              <Formula id="421a1068-39dc-43cc-90e3-15bb847d04e4" name="PARAM_pKa_pH_WS_pls_F1" formula="CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1">
                 <Paths>
                   <Path path="2" as="3" />
                   <Path path="52" as="53" />
@@ -3259,7 +3595,7 @@
                   <Path path="68" as="57" />
                 </Paths>
               </Formula>
-              <Formula id="67b6741f-d337-4e42-a35e-0e145400eb60" name="PARAM_pKa_pH_WS_pls_F2" dim="Dimensionless" formula="CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1">
+              <Formula id="67b6741f-d337-4e42-a35e-0e145400eb60" name="PARAM_pKa_pH_WS_pls_F2" formula="CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1">
                 <Paths>
                   <Path path="4" as="5" />
                   <Path path="52" as="53" />
@@ -3267,7 +3603,7 @@
                   <Path path="68" as="57" />
                 </Paths>
               </Formula>
-              <Formula id="8806016d-c22d-4974-ab1c-98a21396d378" name="PARAM_pKa_pH_WS_pls_F3" dim="Dimensionless" formula="CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1">
+              <Formula id="8806016d-c22d-4974-ab1c-98a21396d378" name="PARAM_pKa_pH_WS_pls_F3" formula="CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1">
                 <Paths>
                   <Path path="6" as="7" />
                   <Path path="52" as="53" />
@@ -3275,63 +3611,63 @@
                   <Path path="68" as="57" />
                 </Paths>
               </Formula>
-              <Formula id="15071fe6-742e-494c-a60a-da8e8ddd4f7c" name="PARAM_pKa_pH_WS_pls_K1" dim="Dimensionless" formula="F1*F2*F3">
+              <Formula id="15071fe6-742e-494c-a60a-da8e8ddd4f7c" name="PARAM_pKa_pH_WS_pls_K1" formula="F1*F2*F3">
                 <Paths>
                   <Path path="69" as="63" />
                   <Path path="70" as="65" />
                   <Path path="71" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="50da2fa1-e86a-4397-8a0a-0f5621907c9f" name="PARAM_pKa_pH_WS_pls_K2" dim="Dimensionless" formula="(1-F1)*F2*F3">
+              <Formula id="50da2fa1-e86a-4397-8a0a-0f5621907c9f" name="PARAM_pKa_pH_WS_pls_K2" formula="(1-F1)*F2*F3">
                 <Paths>
                   <Path path="69" as="63" />
                   <Path path="70" as="65" />
                   <Path path="71" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="0b1897f3-e560-4a6d-907c-b07477c32e1f" name="PARAM_pKa_pH_WS_pls_K3" dim="Dimensionless" formula="F1*(1-F2)*F3">
+              <Formula id="0b1897f3-e560-4a6d-907c-b07477c32e1f" name="PARAM_pKa_pH_WS_pls_K3" formula="F1*(1-F2)*F3">
                 <Paths>
                   <Path path="69" as="63" />
                   <Path path="70" as="65" />
                   <Path path="71" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="3c5083d5-0844-4b7a-ab51-2eaa216eb39d" name="PARAM_pKa_pH_WS_pls_K4" dim="Dimensionless" formula="F1*F2*(1-F3)">
+              <Formula id="3c5083d5-0844-4b7a-ab51-2eaa216eb39d" name="PARAM_pKa_pH_WS_pls_K4" formula="F1*F2*(1-F3)">
                 <Paths>
                   <Path path="69" as="63" />
                   <Path path="70" as="65" />
                   <Path path="71" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="68e21329-d360-4215-86b1-bb307662c85b" name="PARAM_pKa_pH_WS_pls_K5" dim="Dimensionless" formula="(1-F1)*(1-F2)*F3">
+              <Formula id="68e21329-d360-4215-86b1-bb307662c85b" name="PARAM_pKa_pH_WS_pls_K5" formula="(1-F1)*(1-F2)*F3">
                 <Paths>
                   <Path path="69" as="63" />
                   <Path path="70" as="65" />
                   <Path path="71" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="b7334d1d-7f98-4887-8eaa-2548b68694f4" name="PARAM_pKa_pH_WS_pls_K6" dim="Dimensionless" formula="(1-F1)*F2*(1-F3)">
+              <Formula id="b7334d1d-7f98-4887-8eaa-2548b68694f4" name="PARAM_pKa_pH_WS_pls_K6" formula="(1-F1)*F2*(1-F3)">
                 <Paths>
                   <Path path="69" as="63" />
                   <Path path="70" as="65" />
                   <Path path="71" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="69209dc5-6b6f-49dd-beb8-37339c4f6886" name="PARAM_pKa_pH_WS_pls_K7" dim="Dimensionless" formula="F1*(1-F2)*(1-F3)">
+              <Formula id="69209dc5-6b6f-49dd-beb8-37339c4f6886" name="PARAM_pKa_pH_WS_pls_K7" formula="F1*(1-F2)*(1-F3)">
                 <Paths>
                   <Path path="69" as="63" />
                   <Path path="70" as="65" />
                   <Path path="71" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="88bf1db6-8532-4b06-8b50-7313a8be8c87" name="PARAM_pKa_pH_WS_pls_K8" dim="Dimensionless" formula="(1-F1)*(1-F2)*(1-F3)">
+              <Formula id="88bf1db6-8532-4b06-8b50-7313a8be8c87" name="PARAM_pKa_pH_WS_pls_K8" formula="(1-F1)*(1-F2)*(1-F3)">
                 <Paths>
                   <Path path="69" as="63" />
                   <Path path="70" as="65" />
                   <Path path="71" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="83e223a5-a86b-437c-b0c0-cc8e3c1410ed" name="PARAM_pKa_pH_WS_cell_F1" dim="Dimensionless" formula="CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1">
+              <Formula id="83e223a5-a86b-437c-b0c0-cc8e3c1410ed" name="PARAM_pKa_pH_WS_cell_F1" formula="CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1">
                 <Paths>
                   <Path path="72" as="57" />
                   <Path path="41" as="3" />
@@ -3339,7 +3675,7 @@
                   <Path path="74" as="55" />
                 </Paths>
               </Formula>
-              <Formula id="9b431abd-e0ba-4ff1-b1f0-2357edbd7a40" name="PARAM_pKa_pH_WS_cell_F2" dim="Dimensionless" formula="CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1">
+              <Formula id="9b431abd-e0ba-4ff1-b1f0-2357edbd7a40" name="PARAM_pKa_pH_WS_cell_F2" formula="CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1">
                 <Paths>
                   <Path path="72" as="57" />
                   <Path path="42" as="5" />
@@ -3347,7 +3683,7 @@
                   <Path path="75" as="59" />
                 </Paths>
               </Formula>
-              <Formula id="94d08a64-9ebe-4641-8225-2c8ca91ed204" name="PARAM_pKa_pH_WS_cell_F3" dim="Dimensionless" formula="CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1">
+              <Formula id="94d08a64-9ebe-4641-8225-2c8ca91ed204" name="PARAM_pKa_pH_WS_cell_F3" formula="CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1">
                 <Paths>
                   <Path path="72" as="57" />
                   <Path path="43" as="7" />
@@ -3355,63 +3691,63 @@
                   <Path path="76" as="61" />
                 </Paths>
               </Formula>
-              <Formula id="21c3701f-11bb-4b62-9a2b-93cedaf65f4f" name="PARAM_pKa_pH_WS_cell_K1" dim="Dimensionless" formula="F1*F2*F3">
+              <Formula id="21c3701f-11bb-4b62-9a2b-93cedaf65f4f" name="PARAM_pKa_pH_WS_cell_K1" formula="F1*F2*F3">
                 <Paths>
                   <Path path="77" as="63" />
                   <Path path="78" as="65" />
                   <Path path="79" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="74fd7fc8-0ee1-4f19-a4aa-26140f206896" name="PARAM_pKa_pH_WS_cell_K2" dim="Dimensionless" formula="(1-F1)*F2*F3">
+              <Formula id="74fd7fc8-0ee1-4f19-a4aa-26140f206896" name="PARAM_pKa_pH_WS_cell_K2" formula="(1-F1)*F2*F3">
                 <Paths>
                   <Path path="77" as="63" />
                   <Path path="78" as="65" />
                   <Path path="79" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="339c6506-bbce-4585-a801-c612cd6140cc" name="PARAM_pKa_pH_WS_cell_K3" dim="Dimensionless" formula="F1*(1-F2)*F3">
+              <Formula id="339c6506-bbce-4585-a801-c612cd6140cc" name="PARAM_pKa_pH_WS_cell_K3" formula="F1*(1-F2)*F3">
                 <Paths>
                   <Path path="77" as="63" />
                   <Path path="78" as="65" />
                   <Path path="79" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="47f2aaf5-c91f-4fe1-8e6c-3a4b3074fe22" name="PARAM_pKa_pH_WS_cell_K4" dim="Dimensionless" formula="F1*F2*(1-F3)">
+              <Formula id="47f2aaf5-c91f-4fe1-8e6c-3a4b3074fe22" name="PARAM_pKa_pH_WS_cell_K4" formula="F1*F2*(1-F3)">
                 <Paths>
                   <Path path="77" as="63" />
                   <Path path="78" as="65" />
                   <Path path="79" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="d62185a7-1be4-42ea-b68a-9cbaf09fbdf1" name="PARAM_pKa_pH_WS_cell_K5" dim="Dimensionless" formula="(1-F1)*(1-F2)*F3">
+              <Formula id="d62185a7-1be4-42ea-b68a-9cbaf09fbdf1" name="PARAM_pKa_pH_WS_cell_K5" formula="(1-F1)*(1-F2)*F3">
                 <Paths>
                   <Path path="77" as="63" />
                   <Path path="78" as="65" />
                   <Path path="79" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="42bc4456-7f99-454d-810a-8362c6ad04a9" name="PARAM_pKa_pH_WS_cell_K6" dim="Dimensionless" formula="(1-F1)*F2*(1-F3)">
+              <Formula id="42bc4456-7f99-454d-810a-8362c6ad04a9" name="PARAM_pKa_pH_WS_cell_K6" formula="(1-F1)*F2*(1-F3)">
                 <Paths>
                   <Path path="77" as="63" />
                   <Path path="78" as="65" />
                   <Path path="79" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="c3a95cc1-fe8c-48b1-9bd7-698275512eab" name="PARAM_pKa_pH_WS_cell_K7" dim="Dimensionless" formula="F1*(1-F2)*(1-F3)">
+              <Formula id="c3a95cc1-fe8c-48b1-9bd7-698275512eab" name="PARAM_pKa_pH_WS_cell_K7" formula="F1*(1-F2)*(1-F3)">
                 <Paths>
                   <Path path="77" as="63" />
                   <Path path="78" as="65" />
                   <Path path="79" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="ec6bafae-c7eb-47dd-a411-c2fd85325626" name="PARAM_pKa_pH_WS_cell_K8" dim="Dimensionless" formula="(1-F1)*(1-F2)*(1-F3)">
+              <Formula id="ec6bafae-c7eb-47dd-a411-c2fd85325626" name="PARAM_pKa_pH_WS_cell_K8" formula="(1-F1)*(1-F2)*(1-F3)">
                 <Paths>
                   <Path path="77" as="63" />
                   <Path path="78" as="65" />
                   <Path path="79" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="d8023aa8-9188-481c-845b-4a244cdaaa16" name="PARAM_pKa_pH_WS_int_F1" dim="Dimensionless" formula="CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1">
+              <Formula id="d8023aa8-9188-481c-845b-4a244cdaaa16" name="PARAM_pKa_pH_WS_int_F1" formula="CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1">
                 <Paths>
                   <Path path="80" as="57" />
                   <Path path="41" as="3" />
@@ -3419,7 +3755,7 @@
                   <Path path="74" as="55" />
                 </Paths>
               </Formula>
-              <Formula id="217ffd16-92da-4826-bc05-fd5c435e1c79" name="PARAM_pKa_pH_WS_int_F2" dim="Dimensionless" formula="CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1">
+              <Formula id="217ffd16-92da-4826-bc05-fd5c435e1c79" name="PARAM_pKa_pH_WS_int_F2" formula="CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1">
                 <Paths>
                   <Path path="80" as="57" />
                   <Path path="42" as="5" />
@@ -3427,7 +3763,7 @@
                   <Path path="75" as="59" />
                 </Paths>
               </Formula>
-              <Formula id="2540fe6f-35a0-4366-b717-9c3276659c15" name="PARAM_pKa_pH_WS_int_F3" dim="Dimensionless" formula="CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1">
+              <Formula id="2540fe6f-35a0-4366-b717-9c3276659c15" name="PARAM_pKa_pH_WS_int_F3" formula="CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1">
                 <Paths>
                   <Path path="80" as="57" />
                   <Path path="43" as="7" />
@@ -3435,56 +3771,56 @@
                   <Path path="76" as="61" />
                 </Paths>
               </Formula>
-              <Formula id="33a33c98-fa6b-434f-a40a-0a4bf5d5e958" name="PARAM_pKa_pH_WS_int_K1" dim="Dimensionless" formula="F1*F2*F3">
+              <Formula id="33a33c98-fa6b-434f-a40a-0a4bf5d5e958" name="PARAM_pKa_pH_WS_int_K1" formula="F1*F2*F3">
                 <Paths>
                   <Path path="81" as="63" />
                   <Path path="82" as="65" />
                   <Path path="83" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="4678d099-f1ae-485d-9c5d-f33b3f42ee5a" name="PARAM_pKa_pH_WS_int_K2" dim="Dimensionless" formula="(1-F1)*F2*F3">
+              <Formula id="4678d099-f1ae-485d-9c5d-f33b3f42ee5a" name="PARAM_pKa_pH_WS_int_K2" formula="(1-F1)*F2*F3">
                 <Paths>
                   <Path path="81" as="63" />
                   <Path path="82" as="65" />
                   <Path path="83" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="6dd92aff-d107-492c-b704-472476087b8e" name="PARAM_pKa_pH_WS_int_K3" dim="Dimensionless" formula="F1*(1-F2)*F3">
+              <Formula id="6dd92aff-d107-492c-b704-472476087b8e" name="PARAM_pKa_pH_WS_int_K3" formula="F1*(1-F2)*F3">
                 <Paths>
                   <Path path="81" as="63" />
                   <Path path="82" as="65" />
                   <Path path="83" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="a1dee693-2ff7-4fb3-a138-210811538646" name="PARAM_pKa_pH_WS_int_K4" dim="Dimensionless" formula="F1*F2*(1-F3)">
+              <Formula id="a1dee693-2ff7-4fb3-a138-210811538646" name="PARAM_pKa_pH_WS_int_K4" formula="F1*F2*(1-F3)">
                 <Paths>
                   <Path path="81" as="63" />
                   <Path path="82" as="65" />
                   <Path path="83" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="8d02c63c-d1aa-454f-9100-431045826417" name="PARAM_pKa_pH_WS_int_K5" dim="Dimensionless" formula="(1-F1)*(1-F2)*F3">
+              <Formula id="8d02c63c-d1aa-454f-9100-431045826417" name="PARAM_pKa_pH_WS_int_K5" formula="(1-F1)*(1-F2)*F3">
                 <Paths>
                   <Path path="81" as="63" />
                   <Path path="82" as="65" />
                   <Path path="83" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="39433164-c09e-44aa-aa89-f7cbc4a6fa5e" name="PARAM_pKa_pH_WS_int_K6" dim="Dimensionless" formula="(1-F1)*F2*(1-F3)">
+              <Formula id="39433164-c09e-44aa-aa89-f7cbc4a6fa5e" name="PARAM_pKa_pH_WS_int_K6" formula="(1-F1)*F2*(1-F3)">
                 <Paths>
                   <Path path="81" as="63" />
                   <Path path="82" as="65" />
                   <Path path="83" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="50fdc2f0-5db3-4549-b188-fc652a9eb411" name="PARAM_pKa_pH_WS_int_K7" dim="Dimensionless" formula="F1*(1-F2)*(1-F3)">
+              <Formula id="50fdc2f0-5db3-4549-b188-fc652a9eb411" name="PARAM_pKa_pH_WS_int_K7" formula="F1*(1-F2)*(1-F3)">
                 <Paths>
                   <Path path="81" as="63" />
                   <Path path="82" as="65" />
                   <Path path="83" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="a408ed0d-d527-4ade-9125-89dcd556d23f" name="PARAM_pKa_pH_WS_int_K8" dim="Dimensionless" formula="(1-F1)*(1-F2)*(1-F3)">
+              <Formula id="a408ed0d-d527-4ade-9125-89dcd556d23f" name="PARAM_pKa_pH_WS_int_K8" formula="(1-F1)*(1-F2)*(1-F3)">
                 <Paths>
                   <Path path="81" as="63" />
                   <Path path="82" as="65" />
@@ -3580,10 +3916,11 @@
             </StringMap>
           </FormulaCache>
         </CoreCalculationMethod>
-        <CoreCalculationMethod id="8b99c250-6b5e-4f7d-89b5-cadfec0c21bd" name="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim" category="DiffusionIntCell">
+        <CoreCalculationMethod id="8b99c250-6b5e-4f7d-89b5-cadfec0c21bd" name="Cellular permeability - Charge dependent Schmitt normalized to PK-Sim" icon="CoreCalculationMethod" bbVersion="0" category="DiffusionIntCell">
+          <Creation createdAt="5248846133421232566" createdBy="Michael" creationMode="New" origin="Other" />
           <OutputFormulas>
             <KeyValue>
-              <Formula id="3bb3deb7-988f-424e-a89c-604af1a05007" name="PARAM_P_rbc_pls_factor_WS" dim="Dimensionless" formula="K1+ (K2 +K3 +K4)* base ^ 1 + K5* base ^ max(CT0+CT1;-CT0-CT1) +K6* base ^ max(CT0+CT2;-CT0-CT2) +K7* base ^ max(CT2+CT1;-CT2-CT1) +K8* base ^ max(CT0+CT1+CT2;-CT0-CT1-CT2)">
+              <Formula id="3bb3deb7-988f-424e-a89c-604af1a05007" name="PARAM_P_rbc_pls_factor_WS" formula="K1+ (K2 +K3 +K4)* base ^ 1 + K5* base ^ max(CT0+CT1;-CT0-CT1) +K6* base ^ max(CT0+CT2;-CT0-CT2) +K7* base ^ max(CT2+CT1;-CT2-CT1) +K8* base ^ max(CT0+CT1+CT2;-CT0-CT1-CT2)">
                 <Paths>
                   <Path path="0" as="1" />
                   <Path path="2" as="3" />
@@ -3608,7 +3945,7 @@
               </ParameterDescriptor>
             </KeyValue>
             <KeyValue>
-              <Formula id="b01cd8f4-a9bb-42e2-8b28-afbf89be10d1" name="PARAM_P_pls_rbc_factor_WS" dim="Dimensionless" formula="K1+ (K2 +K3 +K4)* base ^ 1 + K5* base ^ max(CT0+CT1;-CT0-CT1) +K6* base ^ max(CT0+CT2;-CT0-CT2) +K7* base ^ max(CT2+CT1;-CT2-CT1) +K8* base ^ max(CT0+CT1+CT2;-CT0-CT1-CT2)">
+              <Formula id="b01cd8f4-a9bb-42e2-8b28-afbf89be10d1" name="PARAM_P_pls_rbc_factor_WS" formula="K1+ (K2 +K3 +K4)* base ^ 1 + K5* base ^ max(CT0+CT1;-CT0-CT1) +K6* base ^ max(CT0+CT2;-CT0-CT2) +K7* base ^ max(CT2+CT1;-CT2-CT1) +K8* base ^ max(CT0+CT1+CT2;-CT0-CT1-CT2)">
                 <Paths>
                   <Path path="0" as="1" />
                   <Path path="2" as="3" />
@@ -3633,7 +3970,7 @@
               </ParameterDescriptor>
             </KeyValue>
             <KeyValue>
-              <Formula id="8a92856b-6024-477f-a672-dfbafe82cd7d" name="PARAM_P_cell_int_factor_WS" dim="Dimensionless" formula="K1+ (K2 +K3 +K4)* base ^ 1 + K5* base ^ max(CT0+CT1;-CT0-CT1) +K6* base ^ max(CT0+CT2;-CT0-CT2) +K7* base ^ max(CT2+CT1;-CT2-CT1) +K8* base ^ max(CT0+CT1+CT2;-CT0-CT1-CT2)">
+              <Formula id="8a92856b-6024-477f-a672-dfbafe82cd7d" name="PARAM_P_cell_int_factor_WS" formula="K1+ (K2 +K3 +K4)* base ^ 1 + K5* base ^ max(CT0+CT1;-CT0-CT1) +K6* base ^ max(CT0+CT2;-CT0-CT2) +K7* base ^ max(CT2+CT1;-CT2-CT1) +K8* base ^ max(CT0+CT1+CT2;-CT0-CT1-CT2)">
                 <Paths>
                   <Path path="32" as="9" />
                   <Path path="33" as="11" />
@@ -3658,7 +3995,7 @@
               </ParameterDescriptor>
             </KeyValue>
             <KeyValue>
-              <Formula id="03be5491-617f-4dda-afb2-dce1e6e0a277" name="PARAM_P_int_cell_factor_WS" dim="Dimensionless" formula="K1+ (K2 +K3 +K4)* base ^ 1 + K5* base ^ max(CT0+CT1;-CT0-CT1) +K6* base ^ max(CT0+CT2;-CT0-CT2) +K7* base ^ max(CT2+CT1;-CT2-CT1) +K8* base ^ max(CT0+CT1+CT2;-CT0-CT1-CT2)">
+              <Formula id="03be5491-617f-4dda-afb2-dce1e6e0a277" name="PARAM_P_int_cell_factor_WS" formula="K1+ (K2 +K3 +K4)* base ^ 1 + K5* base ^ max(CT0+CT1;-CT0-CT1) +K6* base ^ max(CT0+CT2;-CT0-CT2) +K7* base ^ max(CT2+CT1;-CT2-CT1) +K8* base ^ max(CT0+CT1+CT2;-CT0-CT1-CT2)">
                 <Paths>
                   <Path path="44" as="9" />
                   <Path path="45" as="11" />
@@ -3685,7 +4022,9 @@
           </OutputFormulas>
           <HelpParameters>
             <KeyValue>
-              <Parameter id="412542d9-cc9c-4d6c-a9c4-0f7167d9e9e9" name="pKa_pH_WS_bc_F1" persistable="0" isFixedValue="0" formula="223a734b-7042-476e-a90b-d255e89191e5" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="412542d9-cc9c-4d6c-a9c4-0f7167d9e9e9" name="pKa_pH_WS_bc_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="223a734b-7042-476e-a90b-d255e89191e5" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -3693,7 +4032,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="6444ecf5-b751-48ba-aaf9-ef7043cfa5bc" name="pKa_pH_WS_bc_F2" persistable="0" isFixedValue="0" formula="239df7f9-e0fd-4d3d-8dbe-1581383521c4" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="6444ecf5-b751-48ba-aaf9-ef7043cfa5bc" name="pKa_pH_WS_bc_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="239df7f9-e0fd-4d3d-8dbe-1581383521c4" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -3701,7 +4042,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="75331c4d-fe78-40f0-8748-69cd1663b008" name="pKa_pH_WS_bc_F3" persistable="0" isFixedValue="0" formula="5f7a2823-c0f8-4e42-827e-817b762d9c40" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="75331c4d-fe78-40f0-8748-69cd1663b008" name="pKa_pH_WS_bc_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="5f7a2823-c0f8-4e42-827e-817b762d9c40" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -3709,7 +4052,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="c0ff9219-8c5d-4027-816c-a43b7949c579" name="pKa_pH_WS_bc_K1" persistable="0" isFixedValue="0" formula="ac0190b1-6075-4b41-9d7d-0c16ebbb6a9a" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="c0ff9219-8c5d-4027-816c-a43b7949c579" name="pKa_pH_WS_bc_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ac0190b1-6075-4b41-9d7d-0c16ebbb6a9a" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -3717,7 +4062,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="aebe8aac-56a4-4d80-9478-9a3aad885124" name="pKa_pH_WS_bc_K2" persistable="0" isFixedValue="0" formula="3abc5f68-f7f5-44de-9dc1-7b6800bb349f" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="aebe8aac-56a4-4d80-9478-9a3aad885124" name="pKa_pH_WS_bc_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="3abc5f68-f7f5-44de-9dc1-7b6800bb349f" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -3725,7 +4072,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="d15878a7-cb99-4c77-8155-b30b81eb0c68" name="pKa_pH_WS_bc_K3" persistable="0" isFixedValue="0" formula="89bc5060-2f77-436b-9c06-744c77b812c0" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="d15878a7-cb99-4c77-8155-b30b81eb0c68" name="pKa_pH_WS_bc_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="89bc5060-2f77-436b-9c06-744c77b812c0" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -3733,7 +4082,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="2af4b00c-c09d-4e18-a6f1-376ea4f74ce0" name="pKa_pH_WS_bc_K4" persistable="0" isFixedValue="0" formula="5ecefe24-2e4e-401c-b274-d43ff0edade4" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="2af4b00c-c09d-4e18-a6f1-376ea4f74ce0" name="pKa_pH_WS_bc_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="5ecefe24-2e4e-401c-b274-d43ff0edade4" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -3741,7 +4092,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="b159b601-e614-44c8-b2b7-f74860b0e377" name="pKa_pH_WS_bc_K5" persistable="0" isFixedValue="0" formula="5614986d-9c75-49a0-8bfb-3bd3e833190f" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="b159b601-e614-44c8-b2b7-f74860b0e377" name="pKa_pH_WS_bc_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="5614986d-9c75-49a0-8bfb-3bd3e833190f" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -3749,7 +4102,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="36409abb-4734-4169-8370-74234c0ab84e" name="pKa_pH_WS_bc_K6" persistable="0" isFixedValue="0" formula="08bfcadf-2b1d-4406-bdd8-a1be082c920c" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="36409abb-4734-4169-8370-74234c0ab84e" name="pKa_pH_WS_bc_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="08bfcadf-2b1d-4406-bdd8-a1be082c920c" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -3757,7 +4112,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="e1524939-fed0-4eb9-b7cc-950d843610da" name="pKa_pH_WS_bc_K7" persistable="0" isFixedValue="0" formula="19e6005c-24e1-4fae-8e4e-07393ba77ce6" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="e1524939-fed0-4eb9-b7cc-950d843610da" name="pKa_pH_WS_bc_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="19e6005c-24e1-4fae-8e4e-07393ba77ce6" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -3765,7 +4122,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="1c2de948-914e-4250-8f25-e0d6cbdffada" name="pKa_pH_WS_bc_K8" persistable="0" isFixedValue="0" formula="5ac2aefa-1c5d-468f-9ed5-dca19d0b8b98" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="1c2de948-914e-4250-8f25-e0d6cbdffada" name="pKa_pH_WS_bc_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="5ac2aefa-1c5d-468f-9ed5-dca19d0b8b98" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -3773,7 +4132,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="0e3fcab3-8ec7-4789-9a20-a95cc778f286" name="pKa_pH_WS_pls_F1" persistable="0" isFixedValue="0" formula="f5c81e3c-ef96-4fcd-8a79-c3418d76203f" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="0e3fcab3-8ec7-4789-9a20-a95cc778f286" name="pKa_pH_WS_pls_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="f5c81e3c-ef96-4fcd-8a79-c3418d76203f" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -3781,7 +4142,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="def3c7e6-3a5a-49ce-98cb-e7ff87448d5e" name="pKa_pH_WS_pls_F2" persistable="0" isFixedValue="0" formula="e63a561f-8243-43ef-bf50-4650f2910d6e" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="def3c7e6-3a5a-49ce-98cb-e7ff87448d5e" name="pKa_pH_WS_pls_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="e63a561f-8243-43ef-bf50-4650f2910d6e" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -3789,7 +4152,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="49e8fe26-8050-4d03-8268-7cf4b0092287" name="pKa_pH_WS_pls_F3" persistable="0" isFixedValue="0" formula="2cc14770-3ac2-4ee5-a190-aaca7787ca99" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="49e8fe26-8050-4d03-8268-7cf4b0092287" name="pKa_pH_WS_pls_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="2cc14770-3ac2-4ee5-a190-aaca7787ca99" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -3797,7 +4162,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="63389f0c-1aff-49ab-bac6-1c1998ddbfa5" name="pKa_pH_WS_pls_K1" persistable="0" isFixedValue="0" formula="1670a1d0-bf04-4f1e-bb3d-0204c5e0e228" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="63389f0c-1aff-49ab-bac6-1c1998ddbfa5" name="pKa_pH_WS_pls_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="1670a1d0-bf04-4f1e-bb3d-0204c5e0e228" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -3805,7 +4172,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="2bbea305-9ddf-4ad2-bcdd-43da9933fc68" name="pKa_pH_WS_pls_K2" persistable="0" isFixedValue="0" formula="6be7509d-24fe-469c-aed8-cbbe904652ea" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="2bbea305-9ddf-4ad2-bcdd-43da9933fc68" name="pKa_pH_WS_pls_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="6be7509d-24fe-469c-aed8-cbbe904652ea" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -3813,7 +4182,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="7b8e343c-d1b0-418b-9507-27a58012ab01" name="pKa_pH_WS_pls_K3" persistable="0" isFixedValue="0" formula="6fdb7d7e-d7ce-4f1c-ad3c-27b3e0635db5" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="7b8e343c-d1b0-418b-9507-27a58012ab01" name="pKa_pH_WS_pls_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="6fdb7d7e-d7ce-4f1c-ad3c-27b3e0635db5" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -3821,7 +4192,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="f80c7f80-d2d1-47f8-96c6-4f180004d44a" name="pKa_pH_WS_pls_K4" persistable="0" isFixedValue="0" formula="dd5fcc24-7526-4c72-ac3d-ae9a8ef5d46e" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="f80c7f80-d2d1-47f8-96c6-4f180004d44a" name="pKa_pH_WS_pls_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="dd5fcc24-7526-4c72-ac3d-ae9a8ef5d46e" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -3829,7 +4202,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="9bc79594-cdc3-4731-a1a0-a247c154d83a" name="pKa_pH_WS_pls_K5" persistable="0" isFixedValue="0" formula="2625932d-e6a8-4558-967d-f9d893bb768f" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="9bc79594-cdc3-4731-a1a0-a247c154d83a" name="pKa_pH_WS_pls_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="2625932d-e6a8-4558-967d-f9d893bb768f" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -3837,7 +4212,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="055c4419-caac-46f2-97d5-28d4ebd597f9" name="pKa_pH_WS_pls_K6" persistable="0" isFixedValue="0" formula="ad80cfee-c737-4880-94ff-914e207a6257" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="055c4419-caac-46f2-97d5-28d4ebd597f9" name="pKa_pH_WS_pls_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ad80cfee-c737-4880-94ff-914e207a6257" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -3845,7 +4222,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="adf6c3df-611f-4272-9697-85006740ed0d" name="pKa_pH_WS_pls_K7" persistable="0" isFixedValue="0" formula="d2fb166d-7d40-44f5-a12b-c833195efa78" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="adf6c3df-611f-4272-9697-85006740ed0d" name="pKa_pH_WS_pls_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="d2fb166d-7d40-44f5-a12b-c833195efa78" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -3853,7 +4232,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="70939f38-7fd7-4eed-835c-a6af3a0f96dc" name="pKa_pH_WS_pls_K8" persistable="0" isFixedValue="0" formula="98d70ec2-25b8-4977-9798-f29bfec72e35" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="70939f38-7fd7-4eed-835c-a6af3a0f96dc" name="pKa_pH_WS_pls_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="98d70ec2-25b8-4977-9798-f29bfec72e35" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="RootContainer" />
@@ -3861,7 +4242,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="6e4ab734-9241-47e3-99e0-2ab5d863b624" name="pKa_pH_WS_cell_F1" persistable="0" isFixedValue="0" formula="b8ebbf04-11de-4e17-8981-13c8d707379b" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="6e4ab734-9241-47e3-99e0-2ab5d863b624" name="pKa_pH_WS_cell_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="b8ebbf04-11de-4e17-8981-13c8d707379b" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="Neighborhood: Interstitial / Intracellular" />
@@ -3869,7 +4252,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="7785cc7d-fd63-4d34-b2af-837d5198d9f4" name="pKa_pH_WS_cell_F2" persistable="0" isFixedValue="0" formula="bbe2eebd-d1fa-4761-a2f8-6e50b040c96d" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="7785cc7d-fd63-4d34-b2af-837d5198d9f4" name="pKa_pH_WS_cell_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="bbe2eebd-d1fa-4761-a2f8-6e50b040c96d" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="Neighborhood: Interstitial / Intracellular" />
@@ -3877,7 +4262,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="7734fe58-f8f2-4ebf-b452-43acab0f75a7" name="pKa_pH_WS_cell_F3" persistable="0" isFixedValue="0" formula="2ad978d8-c4be-48f9-ba8a-534f39c36c29" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="7734fe58-f8f2-4ebf-b452-43acab0f75a7" name="pKa_pH_WS_cell_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="2ad978d8-c4be-48f9-ba8a-534f39c36c29" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="Neighborhood: Interstitial / Intracellular" />
@@ -3885,7 +4272,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="04792b1a-dce6-4f66-9308-e16d7e629041" name="pKa_pH_WS_cell_K1" persistable="0" isFixedValue="0" formula="5c5da20b-3cee-4d40-8b1f-01bb18e255c1" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="04792b1a-dce6-4f66-9308-e16d7e629041" name="pKa_pH_WS_cell_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="5c5da20b-3cee-4d40-8b1f-01bb18e255c1" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="Neighborhood: Interstitial / Intracellular" />
@@ -3893,7 +4282,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="ac01ab9d-efd6-4391-b35d-400e5302ac33" name="pKa_pH_WS_cell_K2" persistable="0" isFixedValue="0" formula="b8fcbd2d-c999-463b-bebb-0955f954a2f9" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="ac01ab9d-efd6-4391-b35d-400e5302ac33" name="pKa_pH_WS_cell_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="b8fcbd2d-c999-463b-bebb-0955f954a2f9" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="Neighborhood: Interstitial / Intracellular" />
@@ -3901,7 +4292,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="abb1ff55-bf5b-4d87-92bf-48a3d5410158" name="pKa_pH_WS_cell_K3" persistable="0" isFixedValue="0" formula="037d104c-ea54-4761-a4bd-27bf9cd172c2" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="abb1ff55-bf5b-4d87-92bf-48a3d5410158" name="pKa_pH_WS_cell_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="037d104c-ea54-4761-a4bd-27bf9cd172c2" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="Neighborhood: Interstitial / Intracellular" />
@@ -3909,7 +4302,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="281fb1be-44a6-4dc9-9e1e-6b26e2c9da4a" name="pKa_pH_WS_cell_K4" persistable="0" isFixedValue="0" formula="9ee93818-8d06-4f98-9ac5-16846524f529" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="281fb1be-44a6-4dc9-9e1e-6b26e2c9da4a" name="pKa_pH_WS_cell_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="9ee93818-8d06-4f98-9ac5-16846524f529" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="Neighborhood: Interstitial / Intracellular" />
@@ -3917,7 +4312,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="f6742ff1-daf0-4a5a-a5d5-9122aba587cf" name="pKa_pH_WS_cell_K5" persistable="0" isFixedValue="0" formula="a2b27d0b-d4cb-42f1-ab5c-b93b5e8cda8f" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="f6742ff1-daf0-4a5a-a5d5-9122aba587cf" name="pKa_pH_WS_cell_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="a2b27d0b-d4cb-42f1-ab5c-b93b5e8cda8f" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="Neighborhood: Interstitial / Intracellular" />
@@ -3925,7 +4322,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="cc0e777c-1652-4208-be4c-8dcca8d71b91" name="pKa_pH_WS_cell_K6" persistable="0" isFixedValue="0" formula="decfd6e9-cd35-414d-875f-46fdac9becd2" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="cc0e777c-1652-4208-be4c-8dcca8d71b91" name="pKa_pH_WS_cell_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="decfd6e9-cd35-414d-875f-46fdac9becd2" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="Neighborhood: Interstitial / Intracellular" />
@@ -3933,7 +4332,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="bb4369f0-4b2c-4916-880d-a8f2220467e1" name="pKa_pH_WS_cell_K7" persistable="0" isFixedValue="0" formula="7edb4198-c96f-4d6e-a2c3-45f306f57a93" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="bb4369f0-4b2c-4916-880d-a8f2220467e1" name="pKa_pH_WS_cell_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="7edb4198-c96f-4d6e-a2c3-45f306f57a93" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="Neighborhood: Interstitial / Intracellular" />
@@ -3941,7 +4342,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="ca4fb56c-79a9-4d1e-9850-83e49f332540" name="pKa_pH_WS_cell_K8" persistable="0" isFixedValue="0" formula="73783e50-2396-4b70-8cf2-58fe92935282" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="ca4fb56c-79a9-4d1e-9850-83e49f332540" name="pKa_pH_WS_cell_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="73783e50-2396-4b70-8cf2-58fe92935282" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="Neighborhood: Interstitial / Intracellular" />
@@ -3949,7 +4352,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="35bbc80d-7570-480f-8f1a-f1b4deea3f26" name="pKa_pH_WS_int_F1" persistable="0" isFixedValue="0" formula="bfd98340-ba09-4f38-a92f-6595a432f01d" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="35bbc80d-7570-480f-8f1a-f1b4deea3f26" name="pKa_pH_WS_int_F1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="bfd98340-ba09-4f38-a92f-6595a432f01d" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="Neighborhood: Interstitial / Intracellular" />
@@ -3957,7 +4362,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="f2314b69-6103-4c70-a604-d2b0f09e34c7" name="pKa_pH_WS_int_F2" persistable="0" isFixedValue="0" formula="855867be-3253-4feb-9f20-4df88d7a2001" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="f2314b69-6103-4c70-a604-d2b0f09e34c7" name="pKa_pH_WS_int_F2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="855867be-3253-4feb-9f20-4df88d7a2001" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="Neighborhood: Interstitial / Intracellular" />
@@ -3965,7 +4372,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="b6dcb0f1-1d8b-4391-9da4-ec85f4471bdd" name="pKa_pH_WS_int_F3" persistable="0" isFixedValue="0" formula="7cc224cc-3675-4aad-9630-133d8c76b48a" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="b6dcb0f1-1d8b-4391-9da4-ec85f4471bdd" name="pKa_pH_WS_int_F3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="7cc224cc-3675-4aad-9630-133d8c76b48a" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="Neighborhood: Interstitial / Intracellular" />
@@ -3973,7 +4382,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="059afe90-dc20-45a2-8b3e-93c99864d510" name="pKa_pH_WS_int_K1" persistable="0" isFixedValue="0" formula="ecfa72d5-85f9-4405-988a-566a05d50567" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="059afe90-dc20-45a2-8b3e-93c99864d510" name="pKa_pH_WS_int_K1" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ecfa72d5-85f9-4405-988a-566a05d50567" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="Neighborhood: Interstitial / Intracellular" />
@@ -3981,7 +4392,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="f66ab7ec-632f-43b4-9899-89c3e79c937d" name="pKa_pH_WS_int_K2" persistable="0" isFixedValue="0" formula="9e4e86b3-624c-4645-acd7-199aaaf42fb1" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="f66ab7ec-632f-43b4-9899-89c3e79c937d" name="pKa_pH_WS_int_K2" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="9e4e86b3-624c-4645-acd7-199aaaf42fb1" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="Neighborhood: Interstitial / Intracellular" />
@@ -3989,7 +4402,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="aacec881-d814-4692-8305-dab272547efc" name="pKa_pH_WS_int_K3" persistable="0" isFixedValue="0" formula="36f9f826-fdf2-472f-bc89-3117550fb04d" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="aacec881-d814-4692-8305-dab272547efc" name="pKa_pH_WS_int_K3" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="36f9f826-fdf2-472f-bc89-3117550fb04d" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="Neighborhood: Interstitial / Intracellular" />
@@ -3997,7 +4412,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="644698c2-e9eb-4910-8110-8c61cda25325" name="pKa_pH_WS_int_K4" persistable="0" isFixedValue="0" formula="7af3958f-a439-4b6e-93df-512117c98fc2" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="644698c2-e9eb-4910-8110-8c61cda25325" name="pKa_pH_WS_int_K4" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="7af3958f-a439-4b6e-93df-512117c98fc2" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="Neighborhood: Interstitial / Intracellular" />
@@ -4005,7 +4422,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="86a8758d-2d35-4962-99b7-e8b69bfad649" name="pKa_pH_WS_int_K5" persistable="0" isFixedValue="0" formula="801690ab-4087-4dc1-8c8a-dd73e4e91def" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="86a8758d-2d35-4962-99b7-e8b69bfad649" name="pKa_pH_WS_int_K5" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="801690ab-4087-4dc1-8c8a-dd73e4e91def" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="Neighborhood: Interstitial / Intracellular" />
@@ -4013,7 +4432,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="2fc99621-3aa4-4a28-bce9-67b319945a92" name="pKa_pH_WS_int_K6" persistable="0" isFixedValue="0" formula="5d195a1f-83df-4aec-a7cf-0494524e67c1" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="2fc99621-3aa4-4a28-bce9-67b319945a92" name="pKa_pH_WS_int_K6" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="5d195a1f-83df-4aec-a7cf-0494524e67c1" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="Neighborhood: Interstitial / Intracellular" />
@@ -4021,7 +4442,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="9680a917-315e-422f-9f70-6ac1ac14b6df" name="pKa_pH_WS_int_K7" persistable="0" isFixedValue="0" formula="9951abf9-f8de-43ba-bd2f-1675c742836c" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="9680a917-315e-422f-9f70-6ac1ac14b6df" name="pKa_pH_WS_int_K7" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="9951abf9-f8de-43ba-bd2f-1675c742836c" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="Neighborhood: Interstitial / Intracellular" />
@@ -4029,7 +4452,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="9ed0fb03-2d77-4599-a76d-a2a47c016c59" name="pKa_pH_WS_int_K8" persistable="0" isFixedValue="0" formula="d6235f5d-3867-48af-9f68-4ed180a7eddc" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="9ed0fb03-2d77-4599-a76d-a2a47c016c59" name="pKa_pH_WS_int_K8" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="d6235f5d-3867-48af-9f68-4ed180a7eddc" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="Neighborhood: Interstitial / Intracellular" />
@@ -4039,7 +4464,7 @@
           </HelpParameters>
           <FormulaCache>
             <Formulas>
-              <Formula id="223a734b-7042-476e-a90b-d255e89191e5" name="PARAM_pKa_pH_WS_bc_F1" dim="Dimensionless" formula="CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1">
+              <Formula id="223a734b-7042-476e-a90b-d255e89191e5" name="PARAM_pKa_pH_WS_bc_F1" formula="CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1">
                 <Paths>
                   <Path path="2" as="3" />
                   <Path path="52" as="53" />
@@ -4047,7 +4472,7 @@
                   <Path path="56" as="57" />
                 </Paths>
               </Formula>
-              <Formula id="239df7f9-e0fd-4d3d-8dbe-1581383521c4" name="PARAM_pKa_pH_WS_bc_F2" dim="Dimensionless" formula="CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1">
+              <Formula id="239df7f9-e0fd-4d3d-8dbe-1581383521c4" name="PARAM_pKa_pH_WS_bc_F2" formula="CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1">
                 <Paths>
                   <Path path="4" as="5" />
                   <Path path="52" as="53" />
@@ -4055,7 +4480,7 @@
                   <Path path="56" as="57" />
                 </Paths>
               </Formula>
-              <Formula id="5f7a2823-c0f8-4e42-827e-817b762d9c40" name="PARAM_pKa_pH_WS_bc_F3" dim="Dimensionless" formula="CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1">
+              <Formula id="5f7a2823-c0f8-4e42-827e-817b762d9c40" name="PARAM_pKa_pH_WS_bc_F3" formula="CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1">
                 <Paths>
                   <Path path="6" as="7" />
                   <Path path="52" as="53" />
@@ -4063,63 +4488,63 @@
                   <Path path="56" as="57" />
                 </Paths>
               </Formula>
-              <Formula id="ac0190b1-6075-4b41-9d7d-0c16ebbb6a9a" name="PARAM_pKa_pH_WS_bc_K1" dim="Dimensionless" formula="F1*F2*F3">
+              <Formula id="ac0190b1-6075-4b41-9d7d-0c16ebbb6a9a" name="PARAM_pKa_pH_WS_bc_K1" formula="F1*F2*F3">
                 <Paths>
                   <Path path="62" as="63" />
                   <Path path="64" as="65" />
                   <Path path="66" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="3abc5f68-f7f5-44de-9dc1-7b6800bb349f" name="PARAM_pKa_pH_WS_bc_K2" dim="Dimensionless" formula="(1-F1)*F2*F3">
+              <Formula id="3abc5f68-f7f5-44de-9dc1-7b6800bb349f" name="PARAM_pKa_pH_WS_bc_K2" formula="(1-F1)*F2*F3">
                 <Paths>
                   <Path path="62" as="63" />
                   <Path path="64" as="65" />
                   <Path path="66" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="89bc5060-2f77-436b-9c06-744c77b812c0" name="PARAM_pKa_pH_WS_bc_K3" dim="Dimensionless" formula="F1*(1-F2)*F3">
+              <Formula id="89bc5060-2f77-436b-9c06-744c77b812c0" name="PARAM_pKa_pH_WS_bc_K3" formula="F1*(1-F2)*F3">
                 <Paths>
                   <Path path="62" as="63" />
                   <Path path="64" as="65" />
                   <Path path="66" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="5ecefe24-2e4e-401c-b274-d43ff0edade4" name="PARAM_pKa_pH_WS_bc_K4" dim="Dimensionless" formula="F1*F2*(1-F3)">
+              <Formula id="5ecefe24-2e4e-401c-b274-d43ff0edade4" name="PARAM_pKa_pH_WS_bc_K4" formula="F1*F2*(1-F3)">
                 <Paths>
                   <Path path="62" as="63" />
                   <Path path="64" as="65" />
                   <Path path="66" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="5614986d-9c75-49a0-8bfb-3bd3e833190f" name="PARAM_pKa_pH_WS_bc_K5" dim="Dimensionless" formula="(1-F1)*(1-F2)*F3">
+              <Formula id="5614986d-9c75-49a0-8bfb-3bd3e833190f" name="PARAM_pKa_pH_WS_bc_K5" formula="(1-F1)*(1-F2)*F3">
                 <Paths>
                   <Path path="62" as="63" />
                   <Path path="64" as="65" />
                   <Path path="66" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="08bfcadf-2b1d-4406-bdd8-a1be082c920c" name="PARAM_pKa_pH_WS_bc_K6" dim="Dimensionless" formula="(1-F1)*F2*(1-F3)">
+              <Formula id="08bfcadf-2b1d-4406-bdd8-a1be082c920c" name="PARAM_pKa_pH_WS_bc_K6" formula="(1-F1)*F2*(1-F3)">
                 <Paths>
                   <Path path="62" as="63" />
                   <Path path="64" as="65" />
                   <Path path="66" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="19e6005c-24e1-4fae-8e4e-07393ba77ce6" name="PARAM_pKa_pH_WS_bc_K7" dim="Dimensionless" formula="F1*(1-F2)*(1-F3)">
+              <Formula id="19e6005c-24e1-4fae-8e4e-07393ba77ce6" name="PARAM_pKa_pH_WS_bc_K7" formula="F1*(1-F2)*(1-F3)">
                 <Paths>
                   <Path path="62" as="63" />
                   <Path path="64" as="65" />
                   <Path path="66" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="5ac2aefa-1c5d-468f-9ed5-dca19d0b8b98" name="PARAM_pKa_pH_WS_bc_K8" dim="Dimensionless" formula="(1-F1)*(1-F2)*(1-F3)">
+              <Formula id="5ac2aefa-1c5d-468f-9ed5-dca19d0b8b98" name="PARAM_pKa_pH_WS_bc_K8" formula="(1-F1)*(1-F2)*(1-F3)">
                 <Paths>
                   <Path path="62" as="63" />
                   <Path path="64" as="65" />
                   <Path path="66" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="f5c81e3c-ef96-4fcd-8a79-c3418d76203f" name="PARAM_pKa_pH_WS_pls_F1" dim="Dimensionless" formula="CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1">
+              <Formula id="f5c81e3c-ef96-4fcd-8a79-c3418d76203f" name="PARAM_pKa_pH_WS_pls_F1" formula="CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1">
                 <Paths>
                   <Path path="2" as="3" />
                   <Path path="52" as="53" />
@@ -4127,7 +4552,7 @@
                   <Path path="68" as="57" />
                 </Paths>
               </Formula>
-              <Formula id="e63a561f-8243-43ef-bf50-4650f2910d6e" name="PARAM_pKa_pH_WS_pls_F2" dim="Dimensionless" formula="CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1">
+              <Formula id="e63a561f-8243-43ef-bf50-4650f2910d6e" name="PARAM_pKa_pH_WS_pls_F2" formula="CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1">
                 <Paths>
                   <Path path="4" as="5" />
                   <Path path="52" as="53" />
@@ -4135,7 +4560,7 @@
                   <Path path="68" as="57" />
                 </Paths>
               </Formula>
-              <Formula id="2cc14770-3ac2-4ee5-a190-aaca7787ca99" name="PARAM_pKa_pH_WS_pls_F3" dim="Dimensionless" formula="CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1">
+              <Formula id="2cc14770-3ac2-4ee5-a190-aaca7787ca99" name="PARAM_pKa_pH_WS_pls_F3" formula="CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1">
                 <Paths>
                   <Path path="6" as="7" />
                   <Path path="52" as="53" />
@@ -4143,63 +4568,63 @@
                   <Path path="68" as="57" />
                 </Paths>
               </Formula>
-              <Formula id="1670a1d0-bf04-4f1e-bb3d-0204c5e0e228" name="PARAM_pKa_pH_WS_pls_K1" dim="Dimensionless" formula="F1*F2*F3">
+              <Formula id="1670a1d0-bf04-4f1e-bb3d-0204c5e0e228" name="PARAM_pKa_pH_WS_pls_K1" formula="F1*F2*F3">
                 <Paths>
                   <Path path="69" as="63" />
                   <Path path="70" as="65" />
                   <Path path="71" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="6be7509d-24fe-469c-aed8-cbbe904652ea" name="PARAM_pKa_pH_WS_pls_K2" dim="Dimensionless" formula="(1-F1)*F2*F3">
+              <Formula id="6be7509d-24fe-469c-aed8-cbbe904652ea" name="PARAM_pKa_pH_WS_pls_K2" formula="(1-F1)*F2*F3">
                 <Paths>
                   <Path path="69" as="63" />
                   <Path path="70" as="65" />
                   <Path path="71" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="6fdb7d7e-d7ce-4f1c-ad3c-27b3e0635db5" name="PARAM_pKa_pH_WS_pls_K3" dim="Dimensionless" formula="F1*(1-F2)*F3">
+              <Formula id="6fdb7d7e-d7ce-4f1c-ad3c-27b3e0635db5" name="PARAM_pKa_pH_WS_pls_K3" formula="F1*(1-F2)*F3">
                 <Paths>
                   <Path path="69" as="63" />
                   <Path path="70" as="65" />
                   <Path path="71" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="dd5fcc24-7526-4c72-ac3d-ae9a8ef5d46e" name="PARAM_pKa_pH_WS_pls_K4" dim="Dimensionless" formula="F1*F2*(1-F3)">
+              <Formula id="dd5fcc24-7526-4c72-ac3d-ae9a8ef5d46e" name="PARAM_pKa_pH_WS_pls_K4" formula="F1*F2*(1-F3)">
                 <Paths>
                   <Path path="69" as="63" />
                   <Path path="70" as="65" />
                   <Path path="71" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="2625932d-e6a8-4558-967d-f9d893bb768f" name="PARAM_pKa_pH_WS_pls_K5" dim="Dimensionless" formula="(1-F1)*(1-F2)*F3">
+              <Formula id="2625932d-e6a8-4558-967d-f9d893bb768f" name="PARAM_pKa_pH_WS_pls_K5" formula="(1-F1)*(1-F2)*F3">
                 <Paths>
                   <Path path="69" as="63" />
                   <Path path="70" as="65" />
                   <Path path="71" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="ad80cfee-c737-4880-94ff-914e207a6257" name="PARAM_pKa_pH_WS_pls_K6" dim="Dimensionless" formula="(1-F1)*F2*(1-F3)">
+              <Formula id="ad80cfee-c737-4880-94ff-914e207a6257" name="PARAM_pKa_pH_WS_pls_K6" formula="(1-F1)*F2*(1-F3)">
                 <Paths>
                   <Path path="69" as="63" />
                   <Path path="70" as="65" />
                   <Path path="71" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="d2fb166d-7d40-44f5-a12b-c833195efa78" name="PARAM_pKa_pH_WS_pls_K7" dim="Dimensionless" formula="F1*(1-F2)*(1-F3)">
+              <Formula id="d2fb166d-7d40-44f5-a12b-c833195efa78" name="PARAM_pKa_pH_WS_pls_K7" formula="F1*(1-F2)*(1-F3)">
                 <Paths>
                   <Path path="69" as="63" />
                   <Path path="70" as="65" />
                   <Path path="71" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="98d70ec2-25b8-4977-9798-f29bfec72e35" name="PARAM_pKa_pH_WS_pls_K8" dim="Dimensionless" formula="(1-F1)*(1-F2)*(1-F3)">
+              <Formula id="98d70ec2-25b8-4977-9798-f29bfec72e35" name="PARAM_pKa_pH_WS_pls_K8" formula="(1-F1)*(1-F2)*(1-F3)">
                 <Paths>
                   <Path path="69" as="63" />
                   <Path path="70" as="65" />
                   <Path path="71" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="b8ebbf04-11de-4e17-8981-13c8d707379b" name="PARAM_pKa_pH_WS_cell_F1" dim="Dimensionless" formula="CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1">
+              <Formula id="b8ebbf04-11de-4e17-8981-13c8d707379b" name="PARAM_pKa_pH_WS_cell_F1" formula="CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1">
                 <Paths>
                   <Path path="72" as="57" />
                   <Path path="41" as="3" />
@@ -4207,7 +4632,7 @@
                   <Path path="74" as="55" />
                 </Paths>
               </Formula>
-              <Formula id="bbe2eebd-d1fa-4761-a2f8-6e50b040c96d" name="PARAM_pKa_pH_WS_cell_F2" dim="Dimensionless" formula="CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1">
+              <Formula id="bbe2eebd-d1fa-4761-a2f8-6e50b040c96d" name="PARAM_pKa_pH_WS_cell_F2" formula="CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1">
                 <Paths>
                   <Path path="72" as="57" />
                   <Path path="42" as="5" />
@@ -4215,7 +4640,7 @@
                   <Path path="75" as="59" />
                 </Paths>
               </Formula>
-              <Formula id="2ad978d8-c4be-48f9-ba8a-534f39c36c29" name="PARAM_pKa_pH_WS_cell_F3" dim="Dimensionless" formula="CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1">
+              <Formula id="2ad978d8-c4be-48f9-ba8a-534f39c36c29" name="PARAM_pKa_pH_WS_cell_F3" formula="CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1">
                 <Paths>
                   <Path path="72" as="57" />
                   <Path path="43" as="7" />
@@ -4223,63 +4648,63 @@
                   <Path path="76" as="61" />
                 </Paths>
               </Formula>
-              <Formula id="5c5da20b-3cee-4d40-8b1f-01bb18e255c1" name="PARAM_pKa_pH_WS_cell_K1" dim="Dimensionless" formula="F1*F2*F3">
+              <Formula id="5c5da20b-3cee-4d40-8b1f-01bb18e255c1" name="PARAM_pKa_pH_WS_cell_K1" formula="F1*F2*F3">
                 <Paths>
                   <Path path="77" as="63" />
                   <Path path="78" as="65" />
                   <Path path="79" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="b8fcbd2d-c999-463b-bebb-0955f954a2f9" name="PARAM_pKa_pH_WS_cell_K2" dim="Dimensionless" formula="(1-F1)*F2*F3">
+              <Formula id="b8fcbd2d-c999-463b-bebb-0955f954a2f9" name="PARAM_pKa_pH_WS_cell_K2" formula="(1-F1)*F2*F3">
                 <Paths>
                   <Path path="77" as="63" />
                   <Path path="78" as="65" />
                   <Path path="79" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="037d104c-ea54-4761-a4bd-27bf9cd172c2" name="PARAM_pKa_pH_WS_cell_K3" dim="Dimensionless" formula="F1*(1-F2)*F3">
+              <Formula id="037d104c-ea54-4761-a4bd-27bf9cd172c2" name="PARAM_pKa_pH_WS_cell_K3" formula="F1*(1-F2)*F3">
                 <Paths>
                   <Path path="77" as="63" />
                   <Path path="78" as="65" />
                   <Path path="79" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="9ee93818-8d06-4f98-9ac5-16846524f529" name="PARAM_pKa_pH_WS_cell_K4" dim="Dimensionless" formula="F1*F2*(1-F3)">
+              <Formula id="9ee93818-8d06-4f98-9ac5-16846524f529" name="PARAM_pKa_pH_WS_cell_K4" formula="F1*F2*(1-F3)">
                 <Paths>
                   <Path path="77" as="63" />
                   <Path path="78" as="65" />
                   <Path path="79" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="a2b27d0b-d4cb-42f1-ab5c-b93b5e8cda8f" name="PARAM_pKa_pH_WS_cell_K5" dim="Dimensionless" formula="(1-F1)*(1-F2)*F3">
+              <Formula id="a2b27d0b-d4cb-42f1-ab5c-b93b5e8cda8f" name="PARAM_pKa_pH_WS_cell_K5" formula="(1-F1)*(1-F2)*F3">
                 <Paths>
                   <Path path="77" as="63" />
                   <Path path="78" as="65" />
                   <Path path="79" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="decfd6e9-cd35-414d-875f-46fdac9becd2" name="PARAM_pKa_pH_WS_cell_K6" dim="Dimensionless" formula="(1-F1)*F2*(1-F3)">
+              <Formula id="decfd6e9-cd35-414d-875f-46fdac9becd2" name="PARAM_pKa_pH_WS_cell_K6" formula="(1-F1)*F2*(1-F3)">
                 <Paths>
                   <Path path="77" as="63" />
                   <Path path="78" as="65" />
                   <Path path="79" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="7edb4198-c96f-4d6e-a2c3-45f306f57a93" name="PARAM_pKa_pH_WS_cell_K7" dim="Dimensionless" formula="F1*(1-F2)*(1-F3)">
+              <Formula id="7edb4198-c96f-4d6e-a2c3-45f306f57a93" name="PARAM_pKa_pH_WS_cell_K7" formula="F1*(1-F2)*(1-F3)">
                 <Paths>
                   <Path path="77" as="63" />
                   <Path path="78" as="65" />
                   <Path path="79" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="73783e50-2396-4b70-8cf2-58fe92935282" name="PARAM_pKa_pH_WS_cell_K8" dim="Dimensionless" formula="(1-F1)*(1-F2)*(1-F3)">
+              <Formula id="73783e50-2396-4b70-8cf2-58fe92935282" name="PARAM_pKa_pH_WS_cell_K8" formula="(1-F1)*(1-F2)*(1-F3)">
                 <Paths>
                   <Path path="77" as="63" />
                   <Path path="78" as="65" />
                   <Path path="79" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="bfd98340-ba09-4f38-a92f-6595a432f01d" name="PARAM_pKa_pH_WS_int_F1" dim="Dimensionless" formula="CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1">
+              <Formula id="bfd98340-ba09-4f38-a92f-6595a432f01d" name="PARAM_pKa_pH_WS_int_F1" formula="CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1">
                 <Paths>
                   <Path path="80" as="57" />
                   <Path path="41" as="3" />
@@ -4287,7 +4712,7 @@
                   <Path path="74" as="55" />
                 </Paths>
               </Formula>
-              <Formula id="855867be-3253-4feb-9f20-4df88d7a2001" name="PARAM_pKa_pH_WS_int_F2" dim="Dimensionless" formula="CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1">
+              <Formula id="855867be-3253-4feb-9f20-4df88d7a2001" name="PARAM_pKa_pH_WS_int_F2" formula="CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1">
                 <Paths>
                   <Path path="80" as="57" />
                   <Path path="42" as="5" />
@@ -4295,7 +4720,7 @@
                   <Path path="75" as="59" />
                 </Paths>
               </Formula>
-              <Formula id="7cc224cc-3675-4aad-9630-133d8c76b48a" name="PARAM_pKa_pH_WS_int_F3" dim="Dimensionless" formula="CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1">
+              <Formula id="7cc224cc-3675-4aad-9630-133d8c76b48a" name="PARAM_pKa_pH_WS_int_F3" formula="CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1">
                 <Paths>
                   <Path path="80" as="57" />
                   <Path path="43" as="7" />
@@ -4303,56 +4728,56 @@
                   <Path path="76" as="61" />
                 </Paths>
               </Formula>
-              <Formula id="ecfa72d5-85f9-4405-988a-566a05d50567" name="PARAM_pKa_pH_WS_int_K1" dim="Dimensionless" formula="F1*F2*F3">
+              <Formula id="ecfa72d5-85f9-4405-988a-566a05d50567" name="PARAM_pKa_pH_WS_int_K1" formula="F1*F2*F3">
                 <Paths>
                   <Path path="81" as="63" />
                   <Path path="82" as="65" />
                   <Path path="83" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="9e4e86b3-624c-4645-acd7-199aaaf42fb1" name="PARAM_pKa_pH_WS_int_K2" dim="Dimensionless" formula="(1-F1)*F2*F3">
+              <Formula id="9e4e86b3-624c-4645-acd7-199aaaf42fb1" name="PARAM_pKa_pH_WS_int_K2" formula="(1-F1)*F2*F3">
                 <Paths>
                   <Path path="81" as="63" />
                   <Path path="82" as="65" />
                   <Path path="83" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="36f9f826-fdf2-472f-bc89-3117550fb04d" name="PARAM_pKa_pH_WS_int_K3" dim="Dimensionless" formula="F1*(1-F2)*F3">
+              <Formula id="36f9f826-fdf2-472f-bc89-3117550fb04d" name="PARAM_pKa_pH_WS_int_K3" formula="F1*(1-F2)*F3">
                 <Paths>
                   <Path path="81" as="63" />
                   <Path path="82" as="65" />
                   <Path path="83" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="7af3958f-a439-4b6e-93df-512117c98fc2" name="PARAM_pKa_pH_WS_int_K4" dim="Dimensionless" formula="F1*F2*(1-F3)">
+              <Formula id="7af3958f-a439-4b6e-93df-512117c98fc2" name="PARAM_pKa_pH_WS_int_K4" formula="F1*F2*(1-F3)">
                 <Paths>
                   <Path path="81" as="63" />
                   <Path path="82" as="65" />
                   <Path path="83" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="801690ab-4087-4dc1-8c8a-dd73e4e91def" name="PARAM_pKa_pH_WS_int_K5" dim="Dimensionless" formula="(1-F1)*(1-F2)*F3">
+              <Formula id="801690ab-4087-4dc1-8c8a-dd73e4e91def" name="PARAM_pKa_pH_WS_int_K5" formula="(1-F1)*(1-F2)*F3">
                 <Paths>
                   <Path path="81" as="63" />
                   <Path path="82" as="65" />
                   <Path path="83" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="5d195a1f-83df-4aec-a7cf-0494524e67c1" name="PARAM_pKa_pH_WS_int_K6" dim="Dimensionless" formula="(1-F1)*F2*(1-F3)">
+              <Formula id="5d195a1f-83df-4aec-a7cf-0494524e67c1" name="PARAM_pKa_pH_WS_int_K6" formula="(1-F1)*F2*(1-F3)">
                 <Paths>
                   <Path path="81" as="63" />
                   <Path path="82" as="65" />
                   <Path path="83" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="9951abf9-f8de-43ba-bd2f-1675c742836c" name="PARAM_pKa_pH_WS_int_K7" dim="Dimensionless" formula="F1*(1-F2)*(1-F3)">
+              <Formula id="9951abf9-f8de-43ba-bd2f-1675c742836c" name="PARAM_pKa_pH_WS_int_K7" formula="F1*(1-F2)*(1-F3)">
                 <Paths>
                   <Path path="81" as="63" />
                   <Path path="82" as="65" />
                   <Path path="83" as="67" />
                 </Paths>
               </Formula>
-              <Formula id="d6235f5d-3867-48af-9f68-4ed180a7eddc" name="PARAM_pKa_pH_WS_int_K8" dim="Dimensionless" formula="(1-F1)*(1-F2)*(1-F3)">
+              <Formula id="d6235f5d-3867-48af-9f68-4ed180a7eddc" name="PARAM_pKa_pH_WS_int_K8" formula="(1-F1)*(1-F2)*(1-F3)">
                 <Paths>
                   <Path path="81" as="63" />
                   <Path path="82" as="65" />
@@ -4448,10 +4873,11 @@
             </StringMap>
           </FormulaCache>
         </CoreCalculationMethod>
-        <CoreCalculationMethod id="9ea27519-285b-457d-9d7c-a2b7687c859c" name="Interstitial partition coefficient method - Schmitt" category="DistributionInterstitial">
+        <CoreCalculationMethod id="9ea27519-285b-457d-9d7c-a2b7687c859c" name="Interstitial partition coefficient method - Schmitt" icon="CoreCalculationMethod" bbVersion="0" category="DistributionInterstitial">
+          <Creation createdAt="5248846133421252513" createdBy="Michael" creationMode="New" origin="Other" />
           <OutputFormulas>
             <KeyValue>
-              <Formula id="8e0f8401-a82c-4b34-b23d-fe77d88441c8" name="PARAM_K_int_pls" dim="Dimensionless" formula="(f_water_int + f_proteins_int_to_pls * (1/fu - f_water_pls)) * fu">
+              <Formula id="8e0f8401-a82c-4b34-b23d-fe77d88441c8" name="PARAM_K_int_pls" formula="(f_water_int + f_proteins_int_to_pls * (1/fu - f_water_pls)) * fu">
                 <Paths>
                   <Path path="0" as="1" dim="2" />
                   <Path path="3" as="4" />
@@ -4468,7 +4894,7 @@
               </ParameterDescriptor>
             </KeyValue>
             <KeyValue>
-              <ConstantFormula id="ca02b761-40ac-46f7-a484-e16baa664064" dim="Dimensionless" value="1" />
+              <ConstantFormula id="ca02b761-40ac-46f7-a484-e16baa664064" value="1" />
               <ParameterDescriptor parameterName="Partition coefficient (interstitial/plasma)">
                 <ContainerCriteria>
                   <DescriptorConditions>
@@ -4480,7 +4906,9 @@
           </OutputFormulas>
           <HelpParameters>
             <KeyValue>
-              <Parameter id="5b425ee0-80df-45a2-91c6-979444bc12d6" name="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" formula="5958574d-758f-4e82-84c5-61a4ad52c2ec" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="5b425ee0-80df-45a2-91c6-979444bc12d6" name="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="5958574d-758f-4e82-84c5-61a4ad52c2ec" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="Bone_int_Bone_cell" />
@@ -4488,7 +4916,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="56fc8430-c7ec-4fce-8d50-6b97952b98e1" name="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" formula="9eb985bd-e710-4aff-bf78-1f92f8cf690a" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="56fc8430-c7ec-4fce-8d50-6b97952b98e1" name="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="9eb985bd-e710-4aff-bf78-1f92f8cf690a" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="Brain_int_Brain_cell" />
@@ -4496,7 +4926,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="cd1d30e6-ef35-42e1-843b-efac631ad169" name="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" formula="64157976-a55a-4a68-b454-63309329f3b1" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="cd1d30e6-ef35-42e1-843b-efac631ad169" name="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="64157976-a55a-4a68-b454-63309329f3b1" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="Fat_int_Fat_cell" />
@@ -4504,7 +4936,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="1b8f3f33-3a5c-4d70-8f61-beb37af8a8a9" name="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" formula="4adfe129-b207-4e60-bfc6-b5304f8f721a" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="1b8f3f33-3a5c-4d70-8f61-beb37af8a8a9" name="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="4adfe129-b207-4e60-bfc6-b5304f8f721a" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="Heart_int_Heart_cell" />
@@ -4512,7 +4946,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="08cc1f65-61e5-4f76-be38-5bd36dd5ba68" name="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" formula="40666874-578f-4f65-9814-b2779a9d263a" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="08cc1f65-61e5-4f76-be38-5bd36dd5ba68" name="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="40666874-578f-4f65-9814-b2779a9d263a" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="Kidney_int_Kidney_cell" />
@@ -4520,7 +4956,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="36e437d0-8431-4444-968c-6bb24e1c7b08" name="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" formula="d58460f0-5245-4c23-a856-befc7703c68c" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="36e437d0-8431-4444-968c-6bb24e1c7b08" name="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="d58460f0-5245-4c23-a856-befc7703c68c" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="Large intestine  neighborhood" />
@@ -4529,7 +4967,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="6b771550-c8fe-4de5-a5f7-4693e0530f80" name="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" formula="e939bfaf-83ba-434f-8b4e-cf3b66151cad" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="6b771550-c8fe-4de5-a5f7-4693e0530f80" name="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="e939bfaf-83ba-434f-8b4e-cf3b66151cad" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="Liver_int_Liver_cell" />
@@ -4537,7 +4977,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="017e3262-a691-4b36-992d-9eb170ae6a9a" name="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" formula="6c79ea05-9abf-4387-9781-5b88f8989716" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="017e3262-a691-4b36-992d-9eb170ae6a9a" name="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="6c79ea05-9abf-4387-9781-5b88f8989716" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="Lung_int_Lung_cell" />
@@ -4545,7 +4987,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="ef677caa-600b-44f3-8839-08ae7589a5ee" name="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" formula="ab91f379-2a0d-44d3-a89b-35eef4bf4c58" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="ef677caa-600b-44f3-8839-08ae7589a5ee" name="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ab91f379-2a0d-44d3-a89b-35eef4bf4c58" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="Muscle_int_Muscle_cell" />
@@ -4553,7 +4997,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="b249214b-3da5-4e9d-a81d-962738d9f61c" name="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" formula="b855d22b-b259-4cbc-ae3d-520d06ca88c8" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="b249214b-3da5-4e9d-a81d-962738d9f61c" name="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="b855d22b-b259-4cbc-ae3d-520d06ca88c8" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="Pancreas_int_Pancreas_cell" />
@@ -4561,7 +5007,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="6e4467a7-ad96-4f96-81a7-993e9b3191d5" name="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" formula="b36ee7a5-0ceb-40a1-ac8d-a0b0e2f3ff04" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="6e4467a7-ad96-4f96-81a7-993e9b3191d5" name="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="b36ee7a5-0ceb-40a1-ac8d-a0b0e2f3ff04" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="Neighborhood: Interstitial / Intracellular" />
@@ -4570,7 +5018,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="68fe4ee4-fdcf-4aae-a02b-564a34b7d7b0" name="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" formula="edefa822-dbd9-4821-b697-a7ed7caa1794" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="68fe4ee4-fdcf-4aae-a02b-564a34b7d7b0" name="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="edefa822-dbd9-4821-b697-a7ed7caa1794" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="Skin_int_Skin_cell" />
@@ -4578,7 +5028,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="73271836-0288-4310-8c07-5fe8fc97039c" name="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" formula="ae482ac4-5851-48ed-9d74-22dc2fdc4fd8" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="73271836-0288-4310-8c07-5fe8fc97039c" name="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="ae482ac4-5851-48ed-9d74-22dc2fdc4fd8" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="Spleen_int_Spleen_cell" />
@@ -4586,7 +5038,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="26a80324-9a32-4612-8f93-694d8c33a5fe" name="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" formula="9cdc12c0-0483-437d-bf94-eece6c38aec8" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="26a80324-9a32-4612-8f93-694d8c33a5fe" name="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="9cdc12c0-0483-437d-bf94-eece6c38aec8" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="Stomach_int_Stomach_cell" />
@@ -4594,7 +5048,9 @@
               </DescriptorCriteria>
             </KeyValue>
             <KeyValue>
-              <Parameter id="e9062a93-1157-450f-8da0-b4058505c4f1" name="Partition coefficient (interstitial/water)" persistable="0" isFixedValue="0" formula="beaa3a12-a726-46fc-a851-f40ce125a1bb" dim="Dimensionless" quantityType="0" visible="0" canBeVaried="1" />
+              <Parameter id="e9062a93-1157-450f-8da0-b4058505c4f1" name="Partition coefficient (interstitial/water)" icon="Parameter" persistable="0" isFixedValue="0" quantityType="Parameter" negativeValuesAllowed="1" formula="beaa3a12-a726-46fc-a851-f40ce125a1bb" isDefault="0">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
               <DescriptorCriteria>
                 <DescriptorConditions>
                   <MatchTagCondition tag="Gonads_int_Gonads_cell" />
@@ -4604,91 +5060,91 @@
           </HelpParameters>
           <FormulaCache>
             <Formulas>
-              <Formula id="5958574d-758f-4e82-84c5-61a4ad52c2ec" name="PARAM_K_water_int_bon_Schmitt" dim="Dimensionless" formula="fu/K_int_pls">
+              <Formula id="5958574d-758f-4e82-84c5-61a4ad52c2ec" name="PARAM_K_water_int_bon_Schmitt" formula="fu/K_int_pls">
                 <Paths>
                   <Path path="0" as="1" dim="2" />
                   <Path path="9" as="10" />
                 </Paths>
               </Formula>
-              <Formula id="9eb985bd-e710-4aff-bf78-1f92f8cf690a" name="PARAM_K_water_int_brn_Schmitt" dim="Dimensionless" formula="fu/K_int_pls">
+              <Formula id="9eb985bd-e710-4aff-bf78-1f92f8cf690a" name="PARAM_K_water_int_brn_Schmitt" formula="fu/K_int_pls">
                 <Paths>
                   <Path path="0" as="1" dim="2" />
                   <Path path="11" as="10" />
                 </Paths>
               </Formula>
-              <Formula id="64157976-a55a-4a68-b454-63309329f3b1" name="PARAM_K_water_int_fat_Schmitt" dim="Dimensionless" formula="fu/K_int_pls">
+              <Formula id="64157976-a55a-4a68-b454-63309329f3b1" name="PARAM_K_water_int_fat_Schmitt" formula="fu/K_int_pls">
                 <Paths>
                   <Path path="0" as="1" dim="2" />
                   <Path path="12" as="10" />
                 </Paths>
               </Formula>
-              <Formula id="4adfe129-b207-4e60-bfc6-b5304f8f721a" name="PARAM_K_water_int_hrt_Schmitt" dim="Dimensionless" formula="fu/K_int_pls">
+              <Formula id="4adfe129-b207-4e60-bfc6-b5304f8f721a" name="PARAM_K_water_int_hrt_Schmitt" formula="fu/K_int_pls">
                 <Paths>
                   <Path path="0" as="1" dim="2" />
                   <Path path="13" as="10" />
                 </Paths>
               </Formula>
-              <Formula id="40666874-578f-4f65-9814-b2779a9d263a" name="PARAM_K_water_int_kid_Schmitt" dim="Dimensionless" formula="fu/K_int_pls">
+              <Formula id="40666874-578f-4f65-9814-b2779a9d263a" name="PARAM_K_water_int_kid_Schmitt" formula="fu/K_int_pls">
                 <Paths>
                   <Path path="0" as="1" dim="2" />
                   <Path path="14" as="10" />
                 </Paths>
               </Formula>
-              <Formula id="d58460f0-5245-4c23-a856-befc7703c68c" name="PARAM_K_water_int_lin_Schmitt" dim="Dimensionless" formula="fu/K_int_pls">
+              <Formula id="d58460f0-5245-4c23-a856-befc7703c68c" name="PARAM_K_water_int_lin_Schmitt" formula="fu/K_int_pls">
                 <Paths>
                   <Path path="0" as="1" dim="2" />
                   <Path path="15" as="10" />
                 </Paths>
               </Formula>
-              <Formula id="e939bfaf-83ba-434f-8b4e-cf3b66151cad" name="PARAM_K_water_int_liv_Schmitt" dim="Dimensionless" formula="fu/K_int_pls">
+              <Formula id="e939bfaf-83ba-434f-8b4e-cf3b66151cad" name="PARAM_K_water_int_liv_Schmitt" formula="fu/K_int_pls">
                 <Paths>
                   <Path path="0" as="1" dim="2" />
                   <Path path="16" as="10" />
                 </Paths>
               </Formula>
-              <Formula id="6c79ea05-9abf-4387-9781-5b88f8989716" name="PARAM_K_water_int_lng_Schmitt" dim="Dimensionless" formula="fu/K_int_pls">
+              <Formula id="6c79ea05-9abf-4387-9781-5b88f8989716" name="PARAM_K_water_int_lng_Schmitt" formula="fu/K_int_pls">
                 <Paths>
                   <Path path="0" as="1" dim="2" />
                   <Path path="17" as="10" />
                 </Paths>
               </Formula>
-              <Formula id="ab91f379-2a0d-44d3-a89b-35eef4bf4c58" name="PARAM_K_water_int_mus_Schmitt" dim="Dimensionless" formula="fu/K_int_pls">
+              <Formula id="ab91f379-2a0d-44d3-a89b-35eef4bf4c58" name="PARAM_K_water_int_mus_Schmitt" formula="fu/K_int_pls">
                 <Paths>
                   <Path path="0" as="1" dim="2" />
                   <Path path="18" as="10" />
                 </Paths>
               </Formula>
-              <Formula id="b855d22b-b259-4cbc-ae3d-520d06ca88c8" name="PARAM_K_water_int_pan_Schmitt" dim="Dimensionless" formula="fu/K_int_pls">
+              <Formula id="b855d22b-b259-4cbc-ae3d-520d06ca88c8" name="PARAM_K_water_int_pan_Schmitt" formula="fu/K_int_pls">
                 <Paths>
                   <Path path="0" as="1" dim="2" />
                   <Path path="19" as="10" />
                 </Paths>
               </Formula>
-              <Formula id="b36ee7a5-0ceb-40a1-ac8d-a0b0e2f3ff04" name="PARAM_K_water_int_sin_Schmitt" dim="Dimensionless" formula="fu/K_int_pls">
+              <Formula id="b36ee7a5-0ceb-40a1-ac8d-a0b0e2f3ff04" name="PARAM_K_water_int_sin_Schmitt" formula="fu/K_int_pls">
                 <Paths>
                   <Path path="0" as="1" dim="2" />
                   <Path path="20" as="10" />
                 </Paths>
               </Formula>
-              <Formula id="edefa822-dbd9-4821-b697-a7ed7caa1794" name="PARAM_K_water_int_skn_Schmitt" dim="Dimensionless" formula="fu/K_int_pls">
+              <Formula id="edefa822-dbd9-4821-b697-a7ed7caa1794" name="PARAM_K_water_int_skn_Schmitt" formula="fu/K_int_pls">
                 <Paths>
                   <Path path="0" as="1" dim="2" />
                   <Path path="21" as="10" />
                 </Paths>
               </Formula>
-              <Formula id="ae482ac4-5851-48ed-9d74-22dc2fdc4fd8" name="PARAM_K_water_int_spl_Schmitt" dim="Dimensionless" formula="fu/K_int_pls">
+              <Formula id="ae482ac4-5851-48ed-9d74-22dc2fdc4fd8" name="PARAM_K_water_int_spl_Schmitt" formula="fu/K_int_pls">
                 <Paths>
                   <Path path="0" as="1" dim="2" />
                   <Path path="22" as="10" />
                 </Paths>
               </Formula>
-              <Formula id="9cdc12c0-0483-437d-bf94-eece6c38aec8" name="PARAM_K_water_int_sto_Schmitt" dim="Dimensionless" formula="fu/K_int_pls">
+              <Formula id="9cdc12c0-0483-437d-bf94-eece6c38aec8" name="PARAM_K_water_int_sto_Schmitt" formula="fu/K_int_pls">
                 <Paths>
                   <Path path="0" as="1" dim="2" />
                   <Path path="23" as="10" />
                 </Paths>
               </Formula>
-              <Formula id="beaa3a12-a726-46fc-a851-f40ce125a1bb" name="PARAM_K_water_int_tes_Schmitt" dim="Dimensionless" formula="fu/K_int_pls">
+              <Formula id="beaa3a12-a726-46fc-a851-f40ce125a1bb" name="PARAM_K_water_int_tes_Schmitt" formula="fu/K_int_pls">
                 <Paths>
                   <Path path="0" as="1" dim="2" />
                   <Path path="24" as="10" />
@@ -4724,40 +5180,23 @@
             </StringMap>
           </FormulaCache>
         </CoreCalculationMethod>
-        <CoreCalculationMethod id="7e8766e5-7408-427b-88a6-1b4170c14c6f" name="No Calculation Method" category="DistributionCellular">
+        <CoreCalculationMethod id="7e8766e5-7408-427b-88a6-1b4170c14c6f" name="No Calculation Method" icon="CoreCalculationMethod" bbVersion="0" category="DistributionCellular">
+          <Creation createdAt="5248846133421262487" createdBy="Michael" creationMode="New" origin="Other" />
           <OutputFormulas />
           <HelpParameters />
-          <FormulaCache>
-            <StringMap />
-          </FormulaCache>
         </CoreCalculationMethod>
-        <CoreCalculationMethod id="44e1bb64-1a96-424f-ac0b-c0729f405f83" name="No Calculation Method" category="DiffusionIntCell">
+        <CoreCalculationMethod id="44e1bb64-1a96-424f-ac0b-c0729f405f83" name="No Calculation Method" icon="CoreCalculationMethod" bbVersion="0" category="DiffusionIntCell">
+          <Creation createdAt="5248846133421262487" createdBy="Michael" creationMode="New" origin="Other" />
           <OutputFormulas />
           <HelpParameters />
-          <FormulaCache>
-            <StringMap />
-          </FormulaCache>
         </CoreCalculationMethod>
-        <CoreCalculationMethod id="d69fa273-2496-4045-823f-0192eab88e9c" name="No Calculation Method" category="DistributionInterstitial">
+        <CoreCalculationMethod id="d69fa273-2496-4045-823f-0192eab88e9c" name="No Calculation Method" icon="CoreCalculationMethod" bbVersion="0" category="DistributionInterstitial">
+          <Creation createdAt="5248846133421262487" createdBy="Michael" creationMode="New" origin="Other" />
           <OutputFormulas />
           <HelpParameters />
-          <FormulaCache>
-            <StringMap />
-          </FormulaCache>
         </CoreCalculationMethod>
       </AllCalculationMethods>
     </BuildConfiguration>
-    <SimulationConfiguration randomSeed="0">
-      <CVODESettings solverName="CVODE1002_2" absTol="1E-09" relTol="0.0001" h0="1E-10" hMax="60" hMin="0" mxStep="100000" useJacobian="1" dynamicName="Solver" />
-      <OutputSchema>
-        <Intervals>
-          <OutputInterval startTime="0" endTime="1440" resolution="4" />
-        </Intervals>
-        <TimePoints>
-          <TimePoint>0</TimePoint>
-        </TimePoints>
-      </OutputSchema>
-    </SimulationConfiguration>
     <Model id="02082a56-cf84-415e-b493-0b56261b95f4" name="Warnings" neighborhoods="735a7949-aebe-4f70-a12a-ac659d2c9b2d">
       <Root id="cf3e2581-6594-4a95-ac0f-dbdfafb826c1" name="Warnings" mode="Logical" containerType="Simulation">
         <Tags>
@@ -4774,15 +5213,17 @@
                   <Tag value="Comp1" />
                 </Tags>
                 <Children>
-                  <Parameter id="fa3203e3-199f-41bd-86ee-22abfbef2b29" name="V" persistable="0" isFixedValue="0" formula="bbf22879-1ae7-4a05-9f34-da9da3220375" dim="Volume" quantityType="0" visible="1" canBeVaried="1" />
-                  <MoleculeAmount id="2edd4957-df9e-4f67-ba71-735181da0841" name="Enzyme" icon="ENZYME" persistable="1" isFixedValue="0" formula="f1f2eaf6-b94d-40d7-a091-e3dcdc0974e9" dim="Amount" quantityType="Enzyme" mode="Logical" scaleFactor="1">
+                  <Parameter id="fa3203e3-199f-41bd-86ee-22abfbef2b29" name="V" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="0" value="1" displayUnit="l">
+                    <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+                  </Parameter>
+                  <MoleculeAmount id="2edd4957-df9e-4f67-ba71-735181da0841" name="Enzyme" icon="ENZYME" persistable="1" isFixedValue="0" dim="Amount" quantityType="Enzyme" negativeValuesAllowed="0" mode="Logical" scaleDivisor="1" value="0" displayUnit="µmol">
                     <Children>
-                      <Observer id="f555028e-7050-45d8-a200-c4bde5cd943d" name="Concentration" persistable="1" isFixedValue="0" formula="38339bdc-0cb8-4b13-a6d4-4afeccb44da7" dim="MolarConcentration" quantityType="Observer" />
+                      <Observer id="f555028e-7050-45d8-a200-c4bde5cd943d" name="Concentration" icon="Observer" persistable="1" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" negativeValuesAllowed="1" formula="FzV5PLd6SESsNf-DSlkFSA" displayUnit="µmol/l" />
                     </Children>
                   </MoleculeAmount>
-                  <MoleculeAmount id="e788f490-375e-4910-ab64-c0b1846bba4c" name="Complex" persistable="1" isFixedValue="0" formula="54357b62-ffc5-4849-a746-c5a1927e5d05" dim="Amount" quantityType="Complex" mode="Logical" scaleFactor="1">
+                  <MoleculeAmount id="e788f490-375e-4910-ab64-c0b1846bba4c" name="Complex" persistable="1" isFixedValue="0" dim="Amount" quantityType="Complex" negativeValuesAllowed="0" mode="Logical" scaleDivisor="1" value="0" displayUnit="µmol">
                     <Children>
-                      <Observer id="30af859d-9f39-4aae-a182-f1f52ace2da6" name="Concentration" persistable="1" isFixedValue="0" formula="38339bdc-0cb8-4b13-a6d4-4afeccb44da7" dim="MolarConcentration" quantityType="Observer" />
+                      <Observer id="30af859d-9f39-4aae-a182-f1f52ace2da6" name="Concentration" icon="Observer" persistable="1" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" negativeValuesAllowed="1" formula="FzV5PLd6SESsNf-DSlkFSA" displayUnit="µmol/l" />
                     </Children>
                   </MoleculeAmount>
                 </Children>
@@ -4792,12 +5233,12 @@
                   <Tag value="Comp2" />
                 </Tags>
                 <Children>
-                  <MoleculeAmount id="dee759a2-bc3b-445a-abf7-ca8a4adc7049" name="Drug" icon="DRUG" persistable="1" isFixedValue="0" formula="a2ab21f7-cce6-43d5-a335-6723e07a6787" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1">
+                  <MoleculeAmount id="dee759a2-bc3b-445a-abf7-ca8a4adc7049" name="Drug" icon="DRUG" persistable="1" isFixedValue="0" dim="Amount" quantityType="Drug" negativeValuesAllowed="0" mode="Logical" scaleDivisor="1" value="0" displayUnit="µmol">
                     <Children>
-                      <Observer id="30254816-e171-4d60-adcf-ed626ed309f5" name="Mass" persistable="1" isFixedValue="0" formula="31c12fa0-1b7a-4b9b-b608-d52937f4455d" dim="Mass" quantityType="Observer" />
+                      <Observer id="30254816-e171-4d60-adcf-ed626ed309f5" name="Mass" icon="Observer" persistable="1" isFixedValue="0" dim="Mass" quantityType="Drug, Observer" negativeValuesAllowed="1" formula="7Q_bRr4jtEG56sj1--hI7w" displayUnit="kg" />
                     </Children>
                   </MoleculeAmount>
-                  <MoleculeAmount id="56a58c3b-f80a-4967-a981-c562fdfc3f54" name="Complex" persistable="1" isFixedValue="0" formula="ff86933d-0867-4234-aa80-ac7de43d0222" dim="Amount" quantityType="Complex" mode="Logical" scaleFactor="1" />
+                  <MoleculeAmount id="56a58c3b-f80a-4967-a981-c562fdfc3f54" name="Complex" persistable="1" isFixedValue="0" dim="Amount" quantityType="Complex" negativeValuesAllowed="0" mode="Logical" scaleDivisor="1" value="0" displayUnit="µmol" />
                 </Children>
               </Container>
               <Container id="2b016f81-a776-41ab-af34-d63ddd0823c9" name="Comp3" mode="Physical" containerType="Compartment">
@@ -4805,16 +5246,18 @@
                   <Tag value="Comp3" />
                 </Tags>
                 <Children>
-                  <Parameter id="1dd9a963-a274-4a2a-8d1e-60588d58ea8d" name="V" persistable="0" isFixedValue="0" formula="a7247d1c-49ba-4cc0-823d-fbfa66000d0b" dim="Volume" quantityType="0" visible="1" canBeVaried="1" />
-                  <MoleculeAmount id="f931ae42-1b04-4798-af36-6e42410440b1" name="Drug" icon="DRUG" persistable="1" isFixedValue="0" formula="08fa2563-1b34-4362-b2d3-e9c6f5f26686" dim="Amount" quantityType="Drug" mode="Logical" scaleFactor="1">
+                  <Parameter id="1dd9a963-a274-4a2a-8d1e-60588d58ea8d" name="V" icon="Parameter" persistable="0" isFixedValue="0" dim="Volume" quantityType="Parameter" negativeValuesAllowed="1" isDefault="0" value="1" displayUnit="l">
+                    <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+                  </Parameter>
+                  <MoleculeAmount id="f931ae42-1b04-4798-af36-6e42410440b1" name="Drug" icon="DRUG" persistable="1" isFixedValue="0" dim="Amount" quantityType="Drug" negativeValuesAllowed="0" mode="Logical" scaleDivisor="1" value="0" displayUnit="µmol">
                     <Children>
-                      <Observer id="7ac761e7-53db-4136-9ed1-5a1ac1915110" name="Concentration" persistable="1" isFixedValue="0" formula="38339bdc-0cb8-4b13-a6d4-4afeccb44da7" dim="MolarConcentration" quantityType="Observer" />
-                      <Observer id="45d847d9-e46b-40a2-8019-67f4d14a52a1" name="Mass" persistable="1" isFixedValue="0" formula="31c12fa0-1b7a-4b9b-b608-d52937f4455d" dim="Mass" quantityType="Observer" />
+                      <Observer id="7ac761e7-53db-4136-9ed1-5a1ac1915110" name="Concentration" icon="Observer" persistable="1" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" negativeValuesAllowed="1" formula="FzV5PLd6SESsNf-DSlkFSA" displayUnit="µmol/l" />
+                      <Observer id="45d847d9-e46b-40a2-8019-67f4d14a52a1" name="Mass" icon="Observer" persistable="1" isFixedValue="0" dim="Mass" quantityType="Drug, Observer" negativeValuesAllowed="1" formula="7Q_bRr4jtEG56sj1--hI7w" displayUnit="kg" />
                     </Children>
                   </MoleculeAmount>
-                  <MoleculeAmount id="9829aa1f-a987-4be7-ad51-8dbbeb5d6f4f" name="Enzyme" icon="ENZYME" persistable="1" isFixedValue="0" formula="82554164-c369-4895-a312-dd8f9aa0d84b" dim="Amount" quantityType="Enzyme" mode="Logical" scaleFactor="1">
+                  <MoleculeAmount id="9829aa1f-a987-4be7-ad51-8dbbeb5d6f4f" name="Enzyme" icon="ENZYME" persistable="1" isFixedValue="0" dim="Amount" quantityType="Enzyme" negativeValuesAllowed="0" mode="Logical" scaleDivisor="1" value="0" displayUnit="µmol">
                     <Children>
-                      <Observer id="8022e9d5-f05b-44b0-a831-1533a95979b2" name="Concentration" persistable="1" isFixedValue="0" formula="38339bdc-0cb8-4b13-a6d4-4afeccb44da7" dim="MolarConcentration" quantityType="Observer" />
+                      <Observer id="8022e9d5-f05b-44b0-a831-1533a95979b2" name="Concentration" icon="Observer" persistable="1" isFixedValue="0" dim="Concentration (molar)" quantityType="Drug, Observer" negativeValuesAllowed="1" formula="FzV5PLd6SESsNf-DSlkFSA" displayUnit="µmol/l" />
                     </Children>
                   </MoleculeAmount>
                 </Children>
@@ -4826,34 +5269,27 @@
           <Container id="1773bc75-16e7-45ec-8185-d583579b029b" name="Complex" mode="Logical" containerType="Molecule" />
           <Container id="af307857-4adc-4f89-b63a-e920bc181790" name="Drug" icon="DRUG" mode="Logical" containerType="Molecule">
             <Children>
-              <Parameter id="31434279-0041-4e45-9335-83169f2e0dad" name="MW" persistable="0" isFixedValue="0" formula="9cd87b76-e7b9-4032-a198-44c30d72f82e" dim="MolecularWeight" quantityType="0" buildMode="Property" visible="1" canBeVaried="1" />
+              <Parameter id="31434279-0041-4e45-9335-83169f2e0dad" name="MW" icon="Parameter" persistable="0" isFixedValue="0" dim="Molecular weight" quantityType="Parameter" negativeValuesAllowed="1" buildMode="Property" isDefault="0" value="1.11E-07" displayUnit="g/mol">
+                <Info flag="10" seq="1" ref="0" bb="2" group="117" />
+              </Parameter>
             </Children>
           </Container>
         </Children>
       </Root>
       <FormulaCache>
         <Formulas>
-          <ConstantFormula id="bbf22879-1ae7-4a05-9f34-da9da3220375" dim="Volume" value="1" />
-          <Formula id="38339bdc-0cb8-4b13-a6d4-4afeccb44da7" name="Conc" dim="MolarConcentration" formula="M/V" origin="d77dbdd5-be28-4f46-aa46-c60b6178a729">
+          <Formula id="FzV5PLd6SESsNf-DSlkFSA" name="Conc" dim="Concentration (molar)" formula="M/V" origin="38339bdc-0cb8-4b13-a6d4-4afeccb44da7">
             <Paths>
               <Path path="0" as="1" dim="2" />
               <Path path="3" as="4" dim="5" />
             </Paths>
           </Formula>
-          <ConstantFormula id="f1f2eaf6-b94d-40d7-a091-e3dcdc0974e9" dim="Amount" value="0" />
-          <ConstantFormula id="54357b62-ffc5-4849-a746-c5a1927e5d05" dim="Amount" value="0" />
-          <Formula id="31c12fa0-1b7a-4b9b-b608-d52937f4455d" name="mass" dim="Mass" formula="M*MW" origin="27a87f7b-3df7-4d84-87cb-52badfd74df4">
+          <Formula id="7Q_bRr4jtEG56sj1--hI7w" name="mass" dim="Mass" formula="M*MW" origin="31c12fa0-1b7a-4b9b-b608-d52937f4455d">
             <Paths>
               <Path path="0" as="1" dim="2" />
               <Path path="6" as="7" dim="8" />
             </Paths>
           </Formula>
-          <ConstantFormula id="a2ab21f7-cce6-43d5-a335-6723e07a6787" dim="Amount" value="0" />
-          <ConstantFormula id="ff86933d-0867-4234-aa80-ac7de43d0222" dim="Amount" value="0" />
-          <ConstantFormula id="a7247d1c-49ba-4cc0-823d-fbfa66000d0b" dim="Volume" value="1" />
-          <ConstantFormula id="08fa2563-1b34-4362-b2d3-e9c6f5f26686" dim="Amount" value="0" />
-          <ConstantFormula id="82554164-c369-4895-a312-dd8f9aa0d84b" dim="Amount" value="0" />
-          <ConstantFormula id="9cd87b76-e7b9-4032-a198-44c30d72f82e" dim="MolecularWeight" value="111" />
         </Formulas>
         <StringMap>
           <Map s=".." id="0" />
@@ -4864,9 +5300,11 @@
           <Map s="Volume" id="5" />
           <Map s="Warnings|Drug|MW" id="6" />
           <Map s="MW" id="7" />
-          <Map s="MolecularWeight" id="8" />
+          <Map s="Molecular weight" id="8" />
         </StringMap>
       </FormulaCache>
     </Model>
+    <Creation createdAt="5248846133421063043" createdBy="Michael" creationMode="New" origin="Other" />
   </Simulation>
+  <Favorites />
 </SimulationTransfer>
\ No newline at end of file
diff --git a/tests/MoBi.Tests/app.config b/tests/MoBi.Tests/app.config
index 2f68fb473..94d16da7c 100644
--- a/tests/MoBi.Tests/app.config
+++ b/tests/MoBi.Tests/app.config
@@ -2,134 +2,10 @@
 <configuration>
   <runtime>
     <assemblyBinding xmlns="urn:schemas-microsoft-com:asm.v1">
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.Utils.v18.2" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.Data.v18.2" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="System.Windows.Forms" publicKeyToken="b77a5c561934e089" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-4.0.0.0" newVersion="4.0.0.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.XtraTreeList.v18.2" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.XtraEditors.v18.2" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.XtraGrid.v18.2" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.XtraLayout.v18.2" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.XtraBars.v18.2" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.XtraCharts.v18.2.UI" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.XtraCharts.v18.2" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.XtraPivotGrid.v18.2" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.PivotGrid.v18.2.Core" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.RichEdit.v18.2.Core" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.XtraRichEdit.v18.2" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.XtraRichEdit.v18.2.Extensions" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.Charts.v18.2.Core" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.Office.v18.2.Core" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.BonusSkins.v18.2" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="MPFitLib" publicKeyToken="be1b3c0b5819660a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-1.1.0.0" newVersion="1.1.0.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="SX" publicKeyToken="882b9c044052e7f6" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-2.7.0.9" newVersion="2.7.0.9" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="ICSharpCode.SharpZipLib" publicKeyToken="1b03e6acf1164f73" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-0.86.0.518" newVersion="0.86.0.518" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="System.Data.SQLite" publicKeyToken="db937bc2d44ff139" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-1.0.110.0" newVersion="1.0.110.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="Northwoods.Go" publicKeyToken="a4e3b7b70161cfe8" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-4.1.0.2" newVersion="4.1.0.2" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="Northwoods.Go.Xml" publicKeyToken="a4e3b7b70161cfe8" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-4.1.0.2" newVersion="4.1.0.2" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="Northwoods.Go.Layout" publicKeyToken="a4e3b7b70161cfe8" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-4.1.0.2" newVersion="4.1.0.2" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="NHibernate" publicKeyToken="aa95f207798dfdb4" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-5.2.0.0" newVersion="5.2.0.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="DevExpress.Printing.v18.2.Core" publicKeyToken="b88d1754d700e49a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-18.2.7.0" newVersion="18.2.7.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="System.ValueTuple" publicKeyToken="cc7b13ffcd2ddd51" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-4.0.2.0" newVersion="4.0.2.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="Iesi.Collections" publicKeyToken="aa95f207798dfdb4" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-4.0.0.4000" newVersion="4.0.0.4000" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="Newtonsoft.Json" publicKeyToken="30ad4fe6b2a6aeed" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-10.0.0.0" newVersion="10.0.0.0" />
-      </dependentAssembly>
-      <dependentAssembly>
-        <assemblyIdentity name="Microsoft.Extensions.Logging.Abstractions" publicKeyToken="adb9793829ddae60" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-2.1.1.0" newVersion="2.1.1.0" />
-      </dependentAssembly>
       <dependentAssembly>
         <assemblyIdentity name="nunit.framework" publicKeyToken="2638cd05610744eb" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-3.11.0.0" newVersion="3.11.0.0" />
+        <bindingRedirect oldVersion="0.0.0.0-3.12.0.0" newVersion="3.12.0.0" />
       </dependentAssembly>
     </assemblyBinding>
   </runtime>
-<startup><supportedRuntime version="v4.0" sku=".NETFramework,Version=v4.6.2" /></startup></configuration>
+</configuration>
\ No newline at end of file
diff --git a/tests/MoBi.Tests/packages.config b/tests/MoBi.Tests/packages.config
deleted file mode 100644
index 7b0614eea..000000000
--- a/tests/MoBi.Tests/packages.config
+++ /dev/null
@@ -1,52 +0,0 @@
-<?xml version="1.0" encoding="utf-8"?>
-<packages>
-  <package id="Antlr3.Runtime" version="3.5.1" targetFramework="net462" />
-  <package id="Castle.Core" version="4.3.1" targetFramework="net462" />
-  <package id="Castle.Windsor" version="4.1.1" targetFramework="net462" />
-  <package id="csmpfit" version="1.1.1" targetFramework="net462" />
-  <package id="Dapper" version="1.60.6" targetFramework="net462" />
-  <package id="FakeItEasy" version="5.1.1" targetFramework="net462" />
-  <package id="FluentNHibernate" version="2.1.2" targetFramework="net462" />
-  <package id="Iesi.Collections" version="4.0.4" targetFramework="net462" />
-  <package id="MathNet.Numerics" version="4.7.0" targetFramework="net462" />
-  <package id="Microsoft.Extensions.Configuration" version="2.2.0" targetFramework="net462" />
-  <package id="Microsoft.Extensions.Configuration.Abstractions" version="2.2.0" targetFramework="net462" />
-  <package id="Microsoft.Extensions.Configuration.Binder" version="2.2.0" targetFramework="net462" />
-  <package id="Microsoft.Extensions.DependencyInjection.Abstractions" version="2.2.0" targetFramework="net462" />
-  <package id="Microsoft.Extensions.Logging" version="2.2.0" targetFramework="net462" />
-  <package id="Microsoft.Extensions.Logging.Abstractions" version="2.2.0" targetFramework="net462" />
-  <package id="Microsoft.Extensions.Options" version="2.2.0" targetFramework="net462" />
-  <package id="Microsoft.Extensions.Primitives" version="2.2.0" targetFramework="net462" />
-  <package id="Newtonsoft.Json" version="12.0.1" targetFramework="net462" />
-  <package id="NHibernate" version="5.2.5" targetFramework="net462" />
-  <package id="Northwoods.GoWin" version="5.2.0" targetFramework="net462" />
-  <package id="NUnit" version="3.11.0" targetFramework="net462" />
-  <package id="OpenCover" version="4.6.519" targetFramework="net462" />
-  <package id="OSPSuite.Assets" version="8.0.4" targetFramework="net462" />
-  <package id="OSPSuite.BDDHelper" version="3.1.0.1" targetFramework="net462" />
-  <package id="OSPSuite.Core" version="8.0.4" targetFramework="net462" />
-  <package id="OSPSuite.DataBinding" version="2.3.0.3" targetFramework="net462" />
-  <package id="OSPSuite.DevExpress.Presentation" version="18.2.7" targetFramework="net462" />
-  <package id="OSPSuite.Engine" version="8.0.4" targetFramework="net462" />
-  <package id="OSPSuite.FuncParser" version="3.0.1.14" targetFramework="net462" />
-  <package id="OSPSuite.Infrastructure" version="8.0.4" targetFramework="net462" />
-  <package id="OSPSuite.Presentation" version="8.0.4" targetFramework="net462" />
-  <package id="OSPSuite.Serializer" version="2.0.1.4" targetFramework="net462" />
-  <package id="OSPSuite.SimModel" version="3.0.1.27" targetFramework="net462" />
-  <package id="OSPSuite.SimModelSolver_CVODES" version="4.0.0.5" />
-  <package id="OSPSuite.SmartXLS" version="2.7.0.9" targetFramework="net462" />
-  <package id="OSPSuite.TeXReporting" version="2.1.1.9" targetFramework="net462" />
-  <package id="OSPSuite.Utility" version="3.0.1.7" targetFramework="net462" />
-  <package id="Remotion.Linq" version="2.2.0" targetFramework="net462" />
-  <package id="Remotion.Linq.EagerFetching" version="2.2.0" targetFramework="net462" />
-  <package id="SharpZipLib" version="1.1.0" targetFramework="net462" />
-  <package id="System.Buffers" version="4.4.0" targetFramework="net462" />
-  <package id="System.ComponentModel.Annotations" version="4.5.0" targetFramework="net462" />
-  <package id="System.Data.SQLite.Core" version="1.0.110.0" targetFramework="net462" />
-  <package id="System.Memory" version="4.5.1" targetFramework="net462" />
-  <package id="System.Numerics.Vectors" version="4.4.0" targetFramework="net462" />
-  <package id="System.Runtime.CompilerServices.Unsafe" version="4.5.1" targetFramework="net462" />
-  <package id="System.ValueTuple" version="4.4.0" targetFramework="net462" />
-  <package id="WindowsAPICodePack-Core" version="1.1.2" targetFramework="net462" />
-  <package id="WindowsAPICodePack-Shell" version="1.1.1" targetFramework="net462" />
-</packages>
\ No newline at end of file
diff --git a/tests/MoBi.UI.Tests/ContextSpecification.cs b/tests/MoBi.UI.Tests/ContextSpecification.cs
deleted file mode 100644
index c068599b5..000000000
--- a/tests/MoBi.UI.Tests/ContextSpecification.cs
+++ /dev/null
@@ -1,24 +0,0 @@
-using System.Threading.Tasks;
-using OSPSuite.BDDHelper;
-using OSPSuite.Engine;
-
-namespace MoBi.UI
-{
-   public abstract class ContextSpecificationAsync<T> : AbstractContextSpecificationAsync<T>
-   {
-      public override async Task GlobalContext()
-      {
-         await base.GlobalContext();
-         EngineRegister.InitFormulaParser();
-      }
-   }
-
-   public abstract class ContextSpecification<T> : AbstractContextSpecification<T>
-   {
-      public override void GlobalContext()
-      {
-         base.GlobalContext();
-         EngineRegister.InitFormulaParser();
-      }
-   }
-}
\ No newline at end of file
diff --git a/tests/MoBi.UI.Tests/MoBi.UI.Tests.csproj b/tests/MoBi.UI.Tests/MoBi.UI.Tests.csproj
index 8b64bcb37..202ce0d4e 100644
--- a/tests/MoBi.UI.Tests/MoBi.UI.Tests.csproj
+++ b/tests/MoBi.UI.Tests/MoBi.UI.Tests.csproj
@@ -1,347 +1,30 @@
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-<Project ToolsVersion="14.0" DefaultTargets="Build" xmlns="http://schemas.microsoft.com/developer/msbuild/2003">
-  <Import Project="..\..\packages\NUnit.3.11.0\build\NUnit.props" Condition="Exists('..\..\packages\NUnit.3.11.0\build\NUnit.props')" />
-  <Import Project="$(MSBuildExtensionsPath)\$(MSBuildToolsVersion)\Microsoft.Common.props" Condition="Exists('$(MSBuildExtensionsPath)\$(MSBuildToolsVersion)\Microsoft.Common.props')" />
+<Project Sdk="Microsoft.NET.Sdk">
+
   <PropertyGroup>
-    <Configuration Condition=" '$(Configuration)' == '' ">Debug</Configuration>
-    <Platform Condition=" '$(Platform)' == '' ">AnyCPU</Platform>
-    <ProjectGuid>{2710573C-9216-4817-AD81-97099597A780}</ProjectGuid>
-    <OutputType>Library</OutputType>
-    <AppDesignerFolder>Properties</AppDesignerFolder>
+    <TargetFramework>net472</TargetFramework>
+
+    <IsPackable>false</IsPackable>
+
     <RootNamespace>MoBi.UI</RootNamespace>
-    <AssemblyName>MoBi.UI.Tests</AssemblyName>
-    <TargetFrameworkVersion>v4.6.2</TargetFrameworkVersion>
-    <FileAlignment>512</FileAlignment>
-    <NuGetPackageImportStamp>
-    </NuGetPackageImportStamp>
-    <TargetFrameworkProfile />
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-    <DebugSymbols>true</DebugSymbols>
-    <DebugType>full</DebugType>
-    <Optimize>false</Optimize>
-    <OutputPath>bin\Debug\</OutputPath>
-    <DefineConstants>DEBUG;TRACE</DefineConstants>
-    <ErrorReport>prompt</ErrorReport>
-    <WarningLevel>4</WarningLevel>
-    <PlatformTarget>x64</PlatformTarget>
-  </PropertyGroup>
-  <PropertyGroup Condition=" '$(Configuration)|$(Platform)' == 'Release|AnyCPU' ">
-    <DebugType>pdbonly</DebugType>
-    <Optimize>true</Optimize>
-    <OutputPath>bin\Release\</OutputPath>
-    <DefineConstants>TRACE</DefineConstants>
-    <ErrorReport>prompt</ErrorReport>
-    <WarningLevel>4</WarningLevel>
-  </PropertyGroup>
-  <ItemGroup>
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-    <Compile Include="Diagram\MoBiReactionDiagramManagerSpecs.cs" />
-    <Compile Include="Properties\AssemblyInfo.cs" />
-    <Compile Include="Diagram\ReactionDiagramPresenterSpecs.cs" />
-  </ItemGroup>
+
   <ItemGroup>
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-      <Project>{3c65ffc2-d9ec-4951-8c35-04854ad34e52}</Project>
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-      <Project>{de743812-f444-42e2-b72d-cf298933e2ba}</Project>
-      <Name>MoBi.UI</Name>
-    </ProjectReference>
+    <PackageReference Include="FakeItEasy" Version="6.0.0" />
+    <PackageReference Include="NUnit3TestAdapter" Version="3.16.1">
+      <PrivateAssets>all</PrivateAssets>
+      <IncludeAssets>runtime; build; native; contentfiles; analyzers; buildtransitive</IncludeAssets>
+    </PackageReference>
+    <PackageReference Include="Microsoft.NET.Test.Sdk" Version="16.4.0" />
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+
   <ItemGroup>
-    <None Include="app.config" />
-    <None Include="packages.config" />
+    <ProjectReference Include="..\..\src\MoBi.Core\MoBi.Core.csproj" />
+    <ProjectReference Include="..\..\src\MoBi.UI\MoBi.UI.csproj" />
   </ItemGroup>
-  <Import Project="$(MSBuildToolsPath)\Microsoft.CSharp.targets" />
-  <Import Project="..\..\packages\System.Data.SQLite.Core.1.0.110.0\build\net46\System.Data.SQLite.Core.targets" Condition="Exists('..\..\packages\System.Data.SQLite.Core.1.0.110.0\build\net46\System.Data.SQLite.Core.targets')" />
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diff --git a/tests/MoBi.UI.Tests/Properties/AssemblyInfo.cs b/tests/MoBi.UI.Tests/Properties/AssemblyInfo.cs
deleted file mode 100644
index 57f17a402..000000000
--- a/tests/MoBi.UI.Tests/Properties/AssemblyInfo.cs
+++ /dev/null
@@ -1,2 +0,0 @@
-using System.Reflection;
-[assembly: AssemblyTitle("MoBi.UI.Tests")]
diff --git a/tests/MoBi.UI.Tests/app.config b/tests/MoBi.UI.Tests/app.config
index 7ab5df246..94d16da7c 100644
--- a/tests/MoBi.UI.Tests/app.config
+++ b/tests/MoBi.UI.Tests/app.config
@@ -2,106 +2,10 @@
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   <runtime>
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+</configuration>
\ No newline at end of file
diff --git a/tests/MoBi.UI.Tests/packages.config b/tests/MoBi.UI.Tests/packages.config
deleted file mode 100644
index 5822d5804..000000000
--- a/tests/MoBi.UI.Tests/packages.config
+++ /dev/null
@@ -1,53 +0,0 @@
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